SGTCid condition conc unit YEH1|YLL012W.score YEH1|YLL012W.strain.pval YEH1|YLL012W.strain.significant YEH1|YLL012W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 4.8461288281723 5.09994338859779e-08 yes 1 6.29468918584085e-07 48 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_822 1487-0950 154 µM 3.80645185537231 1.40615625725784e-05 yes 2 7.04873600135833e-05 18 1958375 SGTC_2379 9035213 200 µM 3.77996837245905 1.59651160250127e-05 yes 3 7.84241406559649e-05 26 646551 SGTC_996 3970-0799 1.8 µM 3.47876086525188 6.3960069581591e-05 yes 4 0.000251868942470892 116 6615648 YGL040C HEM2 SGTC_2602 kawain 100 µM 3.31675891498102 0.000129305505547804 yes 5 0.000455340812307339 51 5369129 SGTC_986 1493-0483 84 µM 3.22747591327371 0.000188192045515248 yes 6 0.000624437774882481 36 40079 SGTC_1988 st071872 53.4 µM 3.22560626833837 0.000189658617607238 yes 7 0.00062853079433356 30 16414116 SGTC_824 1304-0008 100 µM 3.13187789924689 0.000278480296239313 yes 8 0.000868460471925479 75 768245 SGTC_2002 4023503 131 µM 3.08952946686204 0.000330189147136595 yes 9 0.00100236909488807 77 4736863 YCR052W RSC6 SGTC_3315 9136395 68.55 µM 3.06539212716405 0.00036352289199293 yes 10 0.00108692389876234 37 16876844 SGTC_1996 st072960 66.8 µM 3.06292096569357 0.000367106469505554 yes 11 0.00109593970676094 50 1719405 SGTC_2435 5706476 10.6 µM 2.96039457890256 0.000548189845984761 yes 12 0.00153622626913742 71 5725375 SGTC_1312 1218-2183 165 µM 2.87544025528322 0.000757462150505195 yes 13 0.00201732246567919 42 6744073 SGTC_1059 3448-6867 171 µM 2.86220294531392 0.000796026785477317 yes 14 0.00210353712292305 58 3934407 SGTC_1725 st036284 20.55 µM 2.82662685394182 0.000908803404138212 yes 15 0.00235205539857578 91 707914 SGTC_1061 3448-9325 110 µM 2.8247640272771 0.000915094854635261 yes 16 0.00236577239173056 70 723482 SGTC_2375 9072683 200 µM 2.8003271065332 0.00100141779093308 no 17 0.00255254231990624 84 16798029 SGTC_426 0988-0037 14.6 µM 2.79867851197015 0.00100750232784504 no 18 0.00256560987797723 102 5383008 SGTC_1032 k061-1018 98.7 µM 2.67413094763357 0.00157836660474698 no 19 0.0037461594923311 113 4005393 SGTC_3313 9133968 57.047 µM 2.63708521894127 0.00179787206059044 no 20 0.00418109105642824 62 1494643 SGTC_2103 5378138 10 µM 2.60987110219149 0.00197643345703435 no 21 0.00452881721509547 102 244142 SGTC_1211 1056-0033 32.3 µM 2.60694297331213 0.00199657561638142 no 22 0.00456772867448818 64 6741922 SGTC_2341 7987486 176.74 µM 2.60561931669062 0.00200574187173254 no 23 0.00458541628705932 104 1258686 SGTC_623 k072-0108 16.9 µM 2.58317531712706 0.00216709346678894 no 24 0.00489477812987916 113 5382803 SGTC_2965 9082772 38.63 µM 2.5755048243885 0.00222487919916658 no 25 0.00500469384648676 131 16459634 SGTC_669 0108-0021 26.2 µM 2.57087198797841 0.00226045352335739 no 26 0.00507214082475881 210 17201 SGTC_3336 9143619 71.43 µM 2.51529802236544 0.0027292033295642 no 27 0.00594659008094371 109 45595730 SGTC_2970 9090938 41.86 µM 2.48853545349601 0.00298484307845214 no 28 0.00641352236388109 185 17217104 SGTC_1390 3413-2614 145 µM 2.45216655855793 0.00336680423825926 no 29 0.00709994584445903 138 3421432 SGTC_3354 9151612 71.43 µM 2.41157721207107 0.00384449952650041 no 30 0.00794184413693972 114 27261949 SGTC_2309 7664088 163.95 µM 2.36404645443772 0.00448044744145585 no 31 0.00903827288298024 187 704922 SGTC_1125 tnp00248 1.32998 µM 2.36111993927671 0.00452251177520677 no 32 0.00910991843335458 200 24207736 SGTC_3342 9147791 14.508 µM 2.3462555607083 0.00474165669046489 no 33 0.00948155008432464 118 1838168 SGTC_910 3454-3003 490 µM 2.30662821791513 0.00537285233912436 no 34 0.0105377775311296 156 820824 SGTC_988 1497-1057 103 µM 2.30460826480346 0.00540694063927 no 35 0.0105942613407202 142 3533044 SGTC_189 3970-0742 2.116 µM 2.30332431626662 0.0054287080928633 no 36 0.0106303012469849 90 2891807 SGTC_2595 hexamethylquercetagetin 100 µM 2.30113375778151 0.00546602563530816 no 37 0.0106920358662315 146 386331 SGTC_3016 9080866 49.47 µM 2.28449469371121 0.00575700386897144 no 38 0.0111712370434418 168 17066299 SGTC_180 1486-1293 102.781 µM 2.28231581175566 0.00579610795605495 no 39 0.0112353508470765 179 4140536 SGTC_987 1497-1013 404 µM 2.27426637701442 0.0059426213767642 no 40 0.0114749877262887 110 1676435 SGTC_2625 euphol 100 µM 2.26340238186345 0.0061455682603439 no 41 0.0118054480313449 179 6708538 A triterpene alcohol. SGTC_417 st075190 100 µM 2.25336134902684 0.00633857714576933 no 42 0.0121181872345763 147 222757 SGTC_829 1635-0120 117 µM 2.24570857747375 0.00648926241684248 no 43 0.0123613402054999 185 285054 SGTC_3316 9136639 10.545 µM 2.24178547528582 0.00656773119040768 no 44 0.0124876202087041 131 4903665 SGTC_713 1488-1073 324 µM 2.22522325279767 0.00690832831696749 no 45 0.0130331273015426 117 3312542 SGTC_968 1309-0633 340 µM 2.20431758227905 0.00736045465314326 no 46 0.0137510086450481 147 3761976 SGTC_65 0798-0905 34.986 µM 2.20095036490829 0.0074356659691816 no 47 0.0138697689303006 311 3602145 SGTC_2380 9035439 200 µM 2.19812500030587 0.00749929592032731 no 48 0.0139700997008243 191 6462575 SGTC_716 1683-5115 658 µM 2.19373623658418 0.00759908647793507 no 49 0.0141271885789304 173 723597 SGTC_604 1000-0114 314 µM 2.18951001131739 0.00769628451231665 no 50 0.0142798958518912 176 1572745 SGTC_1251 0490-5699 265 µM 2.1865730951511 0.00776447288751807 no 51 0.0143868516123671 208 3883818 SGTC_546 peri-Naphthalide 147 µM 2.1812281175609 0.00788993600903062 no 52 0.014583274054199 168 223824 A penicillin ester. SGTC_1832 st054113 55 µM 2.17420935700535 0.00805739417874344 no 53 0.0148447079914733 119 1251267 SGTC_985 1493-0307 8.71 µM 2.16633973790395 0.00824886060583007 no 54 0.0151426176187191 126 3278274 SGTC_1058 3448-5425 97.3 µM 2.15409716007618 0.00855466683998778 no 55 0.0156162766081629 190 7279705 SGTC_650 1328-0195 38 µM 2.14205927713005 0.00886501328963942 no 56 0.0160943561579719 198 2780821 SGTC_802 4112-3352 742 µM 2.14030753994304 0.00891098722107894 no 57 0.016164960523937 199 704594 SGTC_2034 5197015 53.07 µM 2.13241007872896 0.00912085783501025 no 58 0.01648657478137 171 780676 SGTC_606 k015-0008 38.6 µM 2.11267495430027 0.00966433062546825 no 59 0.0173142992017491 206 1970475 SGTC_1206 3978-0017 132 µM 2.08440946708061 0.0104919329274193 no 60 0.0185614687140464 195 3873677 SGTC_67 0335-0847 266 µM 2.0758185681581 0.0107554136098785 no 61 0.0189553671862275 355 4552207 YOR254C SEC63 SGTC_2107 5363541 170.161 µM 2.07418300193498 0.0108062236168508 no 62 0.019031159132969 187 244052 SGTC_1291 0993-0025 5.79 µM 2.06885030542202 0.0109733415771101 no 63 0.0192800680525875 170 4353356 SGTC_813 k007-0158 173 µM 2.06312692173472 0.0111552003848005 no 64 0.019550285478236 248 6523916 SGTC_1384 3089-0840 101 µM 2.06125864284553 0.0112151290464804 no 65 0.019639185759835 171 1069836 SGTC_2918 7977171 22.06 µM 2.04869805414628 0.0116253477918966 no 66 0.0202458248026603 199 2236483 SGTC_2046 4110841 106 µM 2.04175812945321 0.0118575399002389 no 67 0.0205877647341778 192 44119630 YMR134W ERG29 SGTC_2791 5663188 71.43 µM 2.0343070346408 0.0121113030338681 no 68 0.020960324181197 210 54690634 SGTC_739 1486-1183 203 µM 2.02099986286859 0.0125762315655804 no 69 0.0216398896443254 202 4346692 SGTC_1333 1482-0047 286 µM 2.01987972123228 0.0126160630941174 no 70 0.0216979326125986 237 3811116 SGTC_1630 st005209 31.3 µM 2.00628625606907 0.0131082083700702 no 71 0.0224128577701038 258 3367314 SGTC_3312 9133330 71.43 µM 1.97846606416143 0.0141673580686346 no 72 0.0239380766497941 200 17617324 SGTC_2493 resveratrol 26.09 µM 1.97160781272116 0.0144395162332911 no 73 0.0243271973169225 170 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2919 7978188 46.38 µM 1.96437003235497 0.0147316050822368 no 74 0.0247435977585 218 2980291 SGTC_2253 7938677 135.83 µM 1.95647637012311 0.0150559430402391 no 75 0.02520453170605 197 2301972 SGTC_1123 mangostin 811.285 nM 1.95318106170199 0.0151931469313218 no 76 0.0253990721606811 278 5281650 An antioxidant. SGTC_201 4262-0159 12.803 µM 1.94951715192004 0.0153469577076215 no 77 0.0256168482608675 189 1341029 SGTC_1997 st073024 93.8 µM 1.94771214096795 0.0154232223521319 no 78 0.0257247082797234 210 686268 SGTC_375 3970-0961 9.27 µM 1.93990617553399 0.0157567944832741 no 79 0.0261955467188752 243 2898222 SGTC_552 k242-0005 476 µM 1.9202601493724 0.0166238290040463 no 80 0.0274125236668377 212 4088318 SGTC_2348 9022543 33.42 µM 1.91468754556746 0.0168770753537906 no 81 0.0277661814196463 251 3162678 YDL140C RPO21 SGTC_23 0213-0011 39.996 µM 1.90884160157361 0.0171462822365144 no 82 0.0281412641891054 243 627608 SGTC_2075 5212009 200 µM 1.90568124036525 0.0172933396192747 no 83 0.0283457873258119 194 780898 SGTC_938 3126-1755 342 µM 1.9011912284905 0.0175041198961208 no 84 0.0286384847947503 234 1777771 SGTC_933 2914-0560 114 µM 1.89214296527721 0.0179355537381079 no 85 0.0292359675351275 275 463887 SGTC_1008 4106-0037 6 µM 1.8750090990661 0.0187773936406001 no 86 0.0303957358797298 226 2905394 SGTC_2384 9036245 200 µM 1.87393463704267 0.0188312875167882 no 87 0.030469717343159 256 6462766 SGTC_2337 9009472 200 µM 1.87301746979212 0.0188773957185611 no 88 0.0305329863216535 311 5742383 SGTC_2716 st080858 38.6235 µM 1.8717736568801 0.0189400785979602 no 89 0.0306189621271513 215 5296050 SGTC_2014 4013930 200 µM 1.86764405152671 0.0191494643210985 no 90 0.0309058509505528 312 64556 SGTC_1713 st033146 12.748 µM 1.86735473937012 0.0191642069571845 no 91 0.030926032942343 278 674619 SGTC_182 3448-4371 550.524 µM 1.85538721534115 0.019782553297038 no 92 0.0317704758646016 277 3491403 SGTC_2255 7941087 197.44 µM 1.84994413534998 0.0200693448582632 no 93 0.0321608008826389 301 935561 SGTC_3230 9131665 49.47 µM 1.8484206458013 0.0201502451811663 no 94 0.0322707571461525 108 15943720 SGTC_2220 6782180 200 µM 1.84669178898898 0.0202423857306788 no 95 0.0323959112046086 160 833803 SGTC_2491 paeonol 100 µM 1.84535099567208 0.0203140899008545 no 96 0.0324932483718199 205 11092 Increases levels of cortical cytochrome oxidase. SGTC_2020 4017018 200 µM 1.84111655381535 0.0205419585387718 no 97 0.0328022401563387 262 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_222 nsc-310342 10.666 µM 1.83862721507608 0.0206769256995394 no 98 0.0329850177712277 141 432556 SGTC_3297 9117502 71.43 µM 1.83395595740795 0.020932219735002 no 99 0.0333302660652086 212 7453720 SGTC_443 clozapine 122 µM 1.82341415580062 0.0215181691840239 no 100 0.0341203439592221 194 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_656 4090-1979 187 µM 1.81609919406808 0.0219328576487365 no 101 0.0346775786641352 308 22330961 SGTC_1334 1486-0610 236 µM 1.78240185509564 0.0239313317233051 no 102 0.0373418616087034 307 3742339 SGTC_907 3448-6986 75.5 µM 1.76948333998259 0.0247370428994378 no 103 0.038406624303074 330 590582 SGTC_1267 0828-0272 9.49 µM 1.76814399061841 0.0248218633728371 no 104 0.0385184174163853 311 745334 SGTC_1379 2144-0755 36.5 µM 1.75086573822382 0.0259381323998382 no 105 0.0399845198537626 328 5392327 SGTC_1142 3253-1408 9.78 µM 1.73525734836881 0.0269823314074671 no 106 0.0413476163752403 291 256655 SGTC_2837 9008476 45.46 µM 1.73202099622869 0.0272031781253109 no 107 0.0416349120881827 350 2992805 SGTC_3080 9117754 49.47 µM 1.72796812783959 0.0274818681523977 no 108 0.0419969693539477 335 9550191 SGTC_1924 st058459 75.1 µM 1.72787961407439 0.0274879811457668 no 109 0.042004904954971 261 688683 SGTC_542 3381-0244 89.3 µM 1.72731289988696 0.027527146789207 no 110 0.0420557418401754 357 1112843 SGTC_442 cape 100 µM 1.71348770560533 0.0284971116026792 no 111 0.0433114266307241 275 5281787 SGTC_1186 1319-0216 26 µM 1.70812140019807 0.0288811904169118 no 112 0.0438069094176147 332 4565136 SGTC_780 0109-0199 192 µM 1.69857510799792 0.0295750743476138 no 113 0.0446996349294454 363 610414 SGTC_2310 7668677 200 µM 1.68995474831529 0.0302134908605713 no 114 0.0455183061182498 336 2197143 SGTC_1521 st012942 49.4 µM 1.68681536134825 0.0304488106678385 no 115 0.0458194303791581 366 24207259 SGTC_2523 spermine 47.74 µM 1.68671820697117 0.0304561172465326 no 116 0.0458287747265662 310 1103 A DNA binding polyamine. SGTC_3215 9129942 49.47 µM 1.68617164508526 0.0304972489801497 no 117 0.045881371816152 275 17682944 SGTC_2605 digitonin 300 nM 1.68313443091324 0.0307266549040564 no 118 0.0461745352439362 393 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1182 1222-0449 220 µM 1.67005059354566 0.0317312927677664 no 119 0.0474546770240613 306 658318 SGTC_593 1203-0218 61.7 µM 1.66753648420719 0.0319274131666903 no 120 0.0477038880121038 325 3666956 SGTC_1491 4138-0063 26.5 µM 1.66371441242806 0.0322274819556854 no 121 0.0480847573552242 285 23883227 SGTC_1284 0929-0043 16 µM 1.65680194503278 0.0327760868975404 no 122 0.0487797618291028 368 1239883 SGTC_2374 9071832 200 µM 1.65353166394096 0.0330383016784056 no 123 0.0491113536931896 301 17381698 SGTC_2254 7938975 95.19 µM 1.65092604949459 0.0332484579111753 no 124 0.0493768379803766 425 2969277 SGTC_2121 5257820 149.641 µM 1.65026870928051 0.0333016493575179 no 125 0.049443994590582 360 791256 SGTC_3018 9082602 49.47 µM 1.6486669929403 0.0334315524479353 no 126 0.049607937884744 358 17332089 SGTC_3086 9117350 49.47 µM 1.64591507349258 0.0336557138411681 no 127 0.0498906225619481 222 2679265 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.64545897508401 0.0336929851884854 no 128 0.0499375981087334 235 77254 SGTC_550 4123-0385 25.7 µM 1.64379654360493 0.0338291230171752 no 129 0.050109117784203 341 5731123 SGTC_2831 7999036 19.48 µM 1.6435970147159 0.0338454929692952 no 130 0.0501297355052645 387 2988270 SGTC_916 4466-0038 42 nM 1.64158005285466 0.0340113367639462 no 131 0.0503385321607499 471 5722064 YGL116W CDC20 SGTC_2876 9059903 25.97 µM 1.64131068655635 0.034033535788025 no 132 0.0503664694457927 357 6916095 SGTC_2839 9003951 25.97 µM 1.63462133180084 0.0345886520278563 no 133 0.0510642264986265 314 2990634 SGTC_3352 9151559 45.5865 µM 1.63310512868069 0.0347155026275128 no 134 0.0512234440700585 343 17159339 SGTC_1375 2910-0797 186 µM 1.63036812754019 0.0349454564182668 no 135 0.051511858344569 362 742508 SGTC_635 k038-0028 24.7 µM 1.62868101858787 0.0350878235561101 no 136 0.0516902815273347 370 4035102 SGTC_1219 1469-0211 33.1 µM 1.61857633732665 0.0359505025488897 no 137 0.0527692248889303 317 6822282 SGTC_112 phenothiazine 287.218 µM 1.60856618025017 0.0368221664042993 no 138 0.0538556171383456 355 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1994 st072947 40.9 µM 1.60259050001209 0.0373507031515889 no 139 0.0545125462587847 366 5286565 YDL195W SEC31 SGTC_1228 0124-0032 52.5 µM 1.59325432530277 0.038188859440992 no 140 0.0555515742976812 385 X1228 SGTC_2126 5251174 33.877 µM 1.592582678732 0.0382497433422216 no 141 0.0556269209190181 455 790722 SGTC_2588 indole-3-carbinol 100 µM 1.59031748271206 0.0384556643068944 no 142 0.0558816299126272 436 3712 Induces cell cycle arrest. SGTC_2804 7954240 19.48 µM 1.58570257954792 0.0388779846518963 no 143 0.0564033968727123 409 828705 SGTC_2430 5571206 200 µM 1.57962589998176 0.0394398287620553 no 144 0.0570962821468976 435 1731771 SGTC_3314 9135860 59.4275 µM 1.57637714901544 0.0397429043389581 no 145 0.0574694556994685 378 25252478 SGTC_1499 4480-0877 67.3 µM 1.56734130327292 0.0405958251409752 no 146 0.0585174679588908 312 2861909 SGTC_477 mead ethanolamide 10 µM 1.55999074116208 0.0413005744381202 no 147 0.0593810346019374 209 16061185 SGTC_1132 3456-3614 2.5 µM 1.55923079557058 0.0413739979152874 no 148 0.0594708822527701 494 3125502 SGTC_2843 9000894 45.46 µM 1.55707857742162 0.0415825124551927 no 149 0.0597259152698005 256 2242070 SGTC_2536 dehydroabietamide 32.04 µM 1.5564937829082 0.0416393162788721 no 150 0.0597953599458916 425 3983547 SGTC_1825 st052143 62.6 µM 1.55609202479439 0.0416783773353304 no 151 0.0598431055917072 327 674173 SGTC_373 0844-0104 25.9 µM 1.55347609582011 0.0419334381682115 no 152 0.0601547178632362 404 5375804 SGTC_1346 1488-2224 62.4 µM 1.55031335968154 0.0422435002923489 no 153 0.0605331611517098 390 3722427 SGTC_446 go6976 132 µM 1.54968685190619 0.0423051402173904 no 154 0.0606083477131531 348 3501 A protein kinase C inhibitor. SGTC_1000 4048-0884 8.67 µM 1.5472395748137 0.0425466169161999 no 155 0.0609027431681956 405 13040088 SGTC_39 0986-0283 58.349 µM 1.54337811474999 0.0429298989535853 no 156 0.0613695302667783 462 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1691 st019933 84.6 µM 1.54119974857316 0.0431473478813625 no 157 0.061634089343723 365 6176082 SGTC_1939 st074455 53.6 µM 1.54086294737172 0.0431810473308924 no 158 0.061675072678498 416 1644229 SGTC_533 1222-0222 6.71 µM 1.53905024274434 0.0433627870957769 no 159 0.0618960154632456 441 3982874 SGTC_2532 xanthone 78.9 µM 1.53730777125399 0.0435380670237576 no 160 0.0621089796665471 376 7020 An insecticide. SGTC_761 k216-0224 480 µM 1.53471227786934 0.0438002145850412 no 161 0.0624272593032465 419 1340404 SGTC_807 1315-0151 48 µM 1.53294966531387 0.0439789652054639 no 162 0.0626441286993543 454 4011080 SGTC_110 0850-0284 111.64 µM 1.53186054416007 0.0440897092505576 no 163 0.0627784258920408 267 3906265 SGTC_2928 9011484 9.79 µM 1.5303015269922 0.0442486244395129 no 164 0.0629710552495817 366 2994751 SGTC_1973 st070275 50.2 µM 1.52832922317243 0.044450328291366 no 165 0.0632154088884604 370 17118334 SGTC_1305 1181-0477 144 µM 1.52650227811289 0.044637826888466 no 166 0.0634424117671928 390 6252086 SGTC_3125 9127534 49.47 µM 1.52162980563225 0.0451410029647179 no 167 0.0640509324543204 290 1639235 SGTC_1813 st051246 8.6015 µM 1.51944958311838 0.0453676258811948 no 168 0.064324684695135 352 5291959 SGTC_3048 9093155 49.47 µM 1.51791767427867 0.0455274066363356 no 169 0.0645175768899823 332 25236002 SGTC_2074 5212007 75.395 µM 1.51165992660885 0.0461848056854242 no 170 0.0653101990399391 339 758611 SGTC_503 tyrphostin 8 294 µM 1.50395878178072 0.047004279075345 no 171 0.0662959900405754 427 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2608 thymoquinone 42.66 µM 1.49634015402017 0.0478264039751581 no 172 0.0672825181572388 368 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3308 9128332 17.569 µM 1.49361259683101 0.048123517863587 no 173 0.0676384525248345 533 17332805 YDL196W YDL196W SGTC_1679 SEC14.276 6.7 µM 1.48412238395285 0.0491688160170029 no 174 0.0688882279495864 504 1005053 YMR079W SEC14 SGTC_759 3486-0358 89.3 µM 1.47872856361353 0.0497709518040955 no 175 0.0696064375100395 484 875103 SGTC_1811 st050069 61.5 µM 1.4774360789407 0.0499161077148314 no 176 0.0697793904653308 354 3877702 SGTC_1295 1013-0063 9.78 µM 1.47334853620871 0.050377393412716 no 177 0.0703285397495872 440 6826038 SGTC_2693 st077581 40.7 µM 1.47167525971041 0.0505672025090735 no 178 0.0705542957826691 546 25238761 SGTC_715 0868-0130 184 µM 1.47164278649086 0.0505708917551045 no 179 0.0705586825257751 388 2876258 SGTC_1494 4358-1428 177 µM 1.46581414652496 0.0512365574869705 no 180 0.0713494630165583 464 1564571 SGTC_1270 0831-1170 17.3 µM 1.46559049061668 0.0512622385590241 no 181 0.0713799417316127 477 6764716 SGTC_3060 1327-0027 12.5 µM 1.46445371087889 0.0513929265273111 no 182 0.0715350109214552 403 16000455 YPR107C YTH1 SGTC_1239 0337-0584 35.4 µM 1.46380501475319 0.0514676214596711 no 183 0.0716236159382624 514 914301 YML130C ERO1 SGTC_1736 st036774 51 µM 1.45473367213193 0.0525212234196303 no 184 0.0728715034274832 464 1272247 SGTC_2845 9003024 42.97 µM 1.44972589126154 0.0531101506245574 no 185 0.073567486342092 471 2990173 SGTC_1716 st033144 30.6155 µM 1.44632330501319 0.0535132818772328 no 186 0.0740432710512346 486 674617 SGTC_2239 6685329 187.64 µM 1.44610665236112 0.0535390323039585 no 187 0.074073645081509 465 805680 SGTC_2640 pentamidine 10.38 µM 1.44559397089629 0.0536000065776017 no 188 0.0741455593463199 502 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2271 7849410 118.62 µM 1.44446392909955 0.0537345990576252 no 189 0.0743042595785433 430 972430 SGTC_1399 3562-5772 25 µM 1.44344292245608 0.0538564350618086 no 190 0.0744478701241062 368 23847490 SGTC_1332 1480-0653 17.5 µM 1.44225690201077 0.0539982365550195 no 191 0.0746149567530102 476 5749438 SGTC_1343 1487-0095 224 µM 1.43165080571263 0.055279485682347 no 192 0.0761218909094737 427 4560101 YGL055W OLE1 SGTC_2745 rifampicin 24.3 µM 1.42937662706777 0.0555573149406446 no 193 0.0764480062672113 289 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_592 k241-0073 46.5 µM 1.42886573827129 0.055619879986997 no 194 0.0765214133001671 474 4230158 SGTC_934 2950-0684 338 µM 1.42539572380912 0.056046301633265 no 195 0.0770214217339672 494 1121253 SGTC_811 0416-0114 265 µM 1.42101092033015 0.0565888223052658 no 196 0.0776567923827676 459 6612453 SGTC_1350 1495-0454 146 µM 1.42007249788772 0.0567054667406413 no 197 0.077793287977786 536 1069057 SGTC_2651 TUB2.036 5 µM 1.41804254560421 0.0569584345628985 no 198 0.0780891718583415 672 15992207 YFL037W TUB2 SGTC_2879 9041815 71.43 µM 1.41418967625717 0.0574410129781113 no 199 0.0786531091743388 337 4942971 SGTC_2751 anetholtrithion 17.25 µM 1.41358139402632 0.0575174944996895 no 200 0.0787424237145278 480 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1974 st069448 26.9 µM 1.41220321025935 0.0576910748568209 no 201 0.0789450677697282 440 6323587 YNR016C ACC1 SGTC_2096 5468907 200 µM 1.4118028654544 0.0577415748702407 no 202 0.0790040072625414 453 759785 SGTC_2297 7971671 152.32 µM 1.40670039855229 0.0583882555064265 no 203 0.0797581237609919 447 909016 SGTC_468 gf-109203x 121 µM 1.40153357984563 0.0590488743939193 no 204 0.080527286621054 330 2396 A protein kinase C inhibitor. SGTC_1634 st006576 41 µM 1.39789874984859 0.0595171192435857 no 205 0.0810717370748532 471 3915356 SGTC_297 0986-0032 24 µM 1.39755943147038 0.0595609789047155 no 206 0.0811227040053776 426 2847425 SGTC_1309 pyrazolanthrone 13.4 µM 1.39534675095339 0.0598476073174587 no 207 0.0814556502354823 508 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1388 3346-4487 254 µM 1.39286925094678 0.060169821152017 no 208 0.0818296661758544 528 3345614 SGTC_216 k038-0035 28.382 µM 1.39128928035674 0.060376014047131 no 209 0.0820688615625183 427 4444231 YPR107C YTH1 SGTC_2130 NSC 7 2.4545 µM 1.39092379305819 0.0604237903598525 no 210 0.0821242684717566 516 21448 SGTC_2408 sulbentine 18.36 µM 1.38883457682542 0.060697459751055 no 211 0.0824415291701375 499 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1938 st074717 56.4 µM 1.38848069287581 0.0607439113747371 no 212 0.0824953599538578 419 17250979 SGTC_794 k038-0031 316 µM 1.38706759378986 0.0609296752317314 no 213 0.0827105762416377 583 6624242 SGTC_325 2810-4341 181 µM 1.38614844047839 0.0610507439335705 no 214 0.0828507907616078 461 774970 SGTC_2829 7992743 58.44 µM 1.38530422029675 0.061162108212766 no 215 0.0829797319120375 493 16462845 SGTC_2490 carminic acid 95.39 µM 1.38294168017802 0.0614746036820536 no 216 0.0833413744102268 408 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1946 st076057 65.1 µM 1.38065908014018 0.0617777085248314 no 217 0.0836919042923725 353 953009 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.38029159257005 0.0618266157850632 no 218 0.0837484412696992 481 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3107 9121808 49.47 µM 1.38021805181488 0.061836406620049 no 219 0.0837597587620513 382 662681 SGTC_760 0568-0725 82.9 µM 1.38014670266314 0.0618459068329371 no 220 0.0837707400774116 498 3916171 SGTC_2324 6149169 200 µM 1.376391564207 0.0623475170569357 no 221 0.0843502191384198 450 2888231 SGTC_989 1501-0895 10.3 µM 1.37610578836703 0.0623858204417322 no 222 0.0843944418718353 459 2830112 SGTC_1606 st000094 49.2 µM 1.37230858706412 0.0628965141239426 no 223 0.0849836967841301 517 1242210 SGTC_2616 abietic acid 100 µM 1.36915144706446 0.0633235994022656 no 224 0.0854759697027504 526 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2847 9005661 71.43 µM 1.36672556360765 0.0636532944055672 no 225 0.0858556709880812 346 2991449 SGTC_936 3005-4620 401 µM 1.36121235415842 0.0644075450173629 no 226 0.0867232955648316 560 777207 SGTC_2004 4023728 41.89 µM 1.3588047515911 0.0647390946867585 no 227 0.0871042336234337 526 360084 YDR527W RBA50 SGTC_865 0488-0499 301 µM 1.35770145464659 0.0648914712683032 no 228 0.0872792175220765 547 9634651 SGTC_294 k038-0071 157 µM 1.35224399380152 0.0656493007429571 no 229 0.0881486371340791 522 24152826 SGTC_1358 1509-0022 2.48 µM 1.34739276195569 0.0663286930604104 no 230 0.0889268852487083 524 3258434 SGTC_746 1095-0025 46.6 µM 1.34305364557636 0.0669409673232583 no 231 0.0896273019006976 548 6749286 SGTC_169 k015-0017 16.025 µM 1.3378944822888 0.067674633858474 no 232 0.0904654180419595 467 1840002 SGTC_2788 5282734 71.43 µM 1.33341623985332 0.0683164917456026 no 233 0.0911976229728697 596 743706 SGTC_2373 9071805 200 µM 1.33308016053621 0.0683648502101109 no 234 0.0912527496238862 525 10149009 SGTC_1209 2323-2347 50.3 µM 1.33286381931325 0.0683959935270726 no 235 0.0912882488608574 494 5412760 SGTC_998 3996-0085 177 µM 1.32884231265992 0.0689769029448624 no 236 0.0919499995917627 581 715391 SGTC_2545 solidagenone 89.61 µM 1.32476409785321 0.0695698801449564 no 237 0.092624703031155 322 6708572 An anti ulcer agent SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.3239567498673 0.0696877335555596 no 238 0.0927587045327418 580 23847180 SGTC_2820 7989630 71.43 µM 1.32159450500981 0.070033447342016 no 239 0.0931516070830577 424 2984098 SGTC_1324 1418-0026 34.4 µM 1.32082583481221 0.0701462260591386 no 240 0.0932797217033617 552 1372513 SGTC_41 0478-0632 82.643 µM 1.31489539811549 0.0710210371484168 no 241 0.0942725297863447 621 3750424 SGTC_808 0711-0032 135 µM 1.31385684713878 0.0711750944506228 no 242 0.0944471914815364 513 4252555 SGTC_2084 5306078 60.6385 µM 1.3133913062502 0.0712442354132325 no 243 0.094525562742966 532 679340 SGTC_1686 st019653 115.5 µM 1.30979552840815 0.0717800097060051 no 244 0.0951325081348955 519 97252 SGTC_2644 guaiazulene 100 µM 1.30873149435206 0.0719391428675246 no 245 0.0953126597326831 512 3515 A coloring agent. SGTC_663 1486-0733 13.9 µM 1.30478222604092 0.0725321474834681 no 246 0.0959835065252399 610 722445 YPR165W RHO1 SGTC_605 1315-0399 119 µM 1.30388270242603 0.0726677380588045 no 247 0.096136789421337 593 24020461 SGTC_425 3825-7017 13.1 µM 1.30003182857463 0.073250398410716 no 248 0.0967950302804324 594 3397440 SGTC_1426 4048-4480 71.7 µM 1.29941579682848 0.0733439384084644 no 249 0.0969006366810348 565 14224343 SGTC_536 3852-0578 10.6 µM 1.28844362531409 0.0750253293043897 no 250 0.0987957904983143 560 2869208 SGTC_3149 9097855 49.47 µM 1.28678641175493 0.0752818181977524 no 251 0.0990843721929707 535 25236625 YMR079W SEC14 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.28079146005599 0.0762152487530222 no 252 0.100133462225678 582 688798 SGTC_1906 st060206 94.7 µM 1.2790661115757 0.0764855159904992 no 253 0.100436888002813 591 5133468 SGTC_1277 0873-0036 22 µM 1.27522980260387 0.077089066739002 no 254 0.101113957809727 618 5965735 SGTC_1271 0832-2808 169 µM 1.27486507409292 0.0771466358564433 no 255 0.101178501460846 588 3663794 SGTC_1620 st003704 16.5 µM 1.27236359509407 0.0775423525161184 no 256 0.101621981293616 572 2834414 SGTC_2336 9001819 198.65 µM 1.26871821365387 0.0781217837136688 no 257 0.102270791996153 605 2989602 SGTC_57 miconazole 162.5 nM 1.2671781355775 0.0783675627894753 no 258 0.102545800943559 537 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3322 9139058 2.11 µM 1.26531757141511 0.0786652693154227 no 259 0.102878755087434 575 4908926 YPR165W RHO1 SGTC_718 1130-0073 349 µM 1.26075763648604 0.0793985223056853 no 260 0.103698090566627 601 6740020 SGTC_163 TUB2.036 7.546 µM 1.26038805642305 0.0794581779108045 no 261 0.103764704043713 756 15992207 YJR013W GPI14 SGTC_2479 5617353 43.85 µM 1.26030479401584 0.0794716223567763 no 262 0.103779715626132 574 2731746 SGTC_1590 st077108 57.8 µM 1.25716618646841 0.0799796722587377 no 263 0.10434673230188 555 5489485 SGTC_2863 9028737 58.44 µM 1.25019769981321 0.0811164429102155 no 264 0.105613668438458 524 6460917 SGTC_2594 a-mangostin 100 µM 1.24885781348711 0.0813364096245741 no 265 0.105858541940629 620 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1146 3579-1023 7 µM 1.24563660877889 0.0818670697728507 no 266 0.106448917930993 647 X1146 SGTC_2362 9071156 126 µM 1.2446383540404 0.0820320503732034 no 267 0.106632357687022 568 653133 SGTC_321 4534-3890 65.3 µM 1.24310052178918 0.0822866964354775 no 268 0.10691539677442 582 699746 SGTC_3133 9127736 49.47 µM 1.24271830262599 0.0823500794873903 no 269 0.106985828494876 602 27243420 SGTC_662 k832-1615 104 µM 1.24233133804843 0.0824142869110976 no 270 0.107057168743401 573 5878478 SGTC_1191 1487-1166 10.6 µM 1.23984321393333 0.0828280316386845 no 271 0.107516695482098 685 3955771 SGTC_2584 androsterone 48.74 µM 1.23933034671773 0.0829135091419861 no 272 0.107611592354888 753 2754130 A steroid. SGTC_1403 3909-7815 62.9 µM 1.23896504246756 0.0829744333779323 no 273 0.107679222142676 532 6615483 SGTC_2809 7964133 12.99 µM 1.23860864817856 0.0830339040854101 no 274 0.107745231909738 607 1253665 SGTC_219 mitoxanthrone 164.414 µM 1.23547073208243 0.0835589054724342 no 275 0.108327681290566 593 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1561 5-methoxyflavone 52.9 µM 1.23379207015106 0.0838407827490331 no 276 0.108640197539892 521 94525 SGTC_2188 6126565 140.678 µM 1.23120617810865 0.0842763967094352 no 277 0.109122880662475 539 874518 SGTC_2492 derrusnin 100 µM 1.23103357487901 0.0843055334493185 no 278 0.109155153595188 528 1715307 Part of coumarin class of compounds. SGTC_961 1252-1571 372 µM 1.23090411917512 0.0843273915189402 no 279 0.109179363409081 606 6813498 SGTC_2278 7948257 134.34 µM 1.22216729000051 0.0858124177425722 no 280 0.110822185389495 601 1247028 SGTC_831 k061-1017 217 µM 1.22077907744986 0.0860501678081594 no 281 0.111084838818003 779 1240153 SGTC_2861 9024595 19.48 µM 1.22028717846594 0.0861345302716894 no 282 0.11117801426956 486 16482810 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.21955841106221 0.0862596302443648 no 283 0.11131616015726 493 1241132 A phosphatase inhibitor. SGTC_2064 5220758 200 µM 1.21942494962756 0.0862825549047129 no 284 0.111341472548421 664 788518 SGTC_1215 3852-0577 11.2 µM 1.21652528057124 0.0867817564203134 no 285 0.111892443361329 678 2884876 SGTC_104 0074-0074 590.992 µM 1.2135494669166 0.0872963075460809 no 286 0.112459906907058 465 3943124 SGTC_492 tmb-8 126 µM 1.20901584689606 0.0880845939612064 no 287 0.113328378650566 425 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2298 7976326 193.81 µM 1.20878372338885 0.088125096954189 no 288 0.113372973203108 542 2235818 SGTC_935 2996-0153 430 µM 1.20674947707538 0.088480644678296 no 289 0.11376431922414 612 23738523 SGTC_218 alverine citrate 93.75 µM 1.20557709265902 0.0886860401389582 no 290 0.113990298088559 584 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2670 beta-carotene 100 µM 1.20521721411503 0.0887491601064186 no 291 0.114059729329042 524 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_3287 9117173 37.0625 µM 1.20470096187512 0.0888397652430885 no 292 0.114159382289323 551 2789709 SGTC_187 1488-2104 32.728 µM 1.20407140217766 0.0889503496523069 no 293 0.114280991062972 636 2852859 SGTC_511 blebbistatin 171 µM 1.2008876421263 0.0895111582922494 no 294 0.114897394289507 603 3476986 A myosin inhibitor. SGTC_2436 5633522 8.09 µM 1.19896968882546 0.089850266114219 no 295 0.115269865981545 650 5724242 SGTC_1255 0566-0045 221 µM 1.19862359583335 0.0899115593885359 no 296 0.115337169483911 628 2788469 SGTC_2708 st078559 56 µM 1.19569992504027 0.0904305837288082 no 297 0.11590684031655 507 17250902 SGTC_450 aminopyrene 156 nM 1.19508792065828 0.0905395107655495 no 298 0.116026340463455 644 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1689 st020265 53.493 µM 1.19370207688652 0.0907865288543838 no 299 0.116297263897294 637 5758320 YPR016C TIF6 SGTC_3021 9087658 49.47 µM 1.19297323353802 0.0909166411764033 no 300 0.116439927997844 580 25237042 SGTC_1875 nocodazole 6 µM 1.19277821998323 0.0909514782326654 no 301 0.116478121075486 623 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2187 6125751 200 µM 1.19026717232872 0.091400934685314 no 302 0.116970699530092 637 874498 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.18560662432269 0.0922394937321121 no 303 0.117888842500612 654 688667 SGTC_2217 6934799 96.0675 µM 1.18271220783938 0.0927631363928586 no 304 0.118461612165772 618 675606 SGTC_381 3461-2219 42.7 µM 1.18218284991817 0.0928591423799233 no 305 0.118566578030019 684 2883159 SGTC_1386 3228-0095 33.8 µM 1.18139488991631 0.0930021852782255 no 306 0.118722943549484 621 870181 SGTC_1177 0983-0204 23.6 µM 1.18124188864952 0.0930299793498903 no 307 0.118753322534889 689 766818 SGTC_993 3909-8757 62.7 µM 1.1791595265447 0.0934088699930166 no 308 0.11916732951686 580 4288324 YLR208W SEC13 SGTC_3226 9131256 49.47 µM 1.17338598874514 0.0944653383238858 no 309 0.120320526682412 513 17178073 SGTC_1138 3761-0006 1.03 µM 1.17309083420188 0.0945195827985476 no 310 0.12037969086753 636 12061087 SGTC_3124 9127567 49.47 µM 1.17307732949713 0.0945220652869796 no 311 0.120382398396662 618 17592030 SGTC_132 0417-1715 25.805 µM 1.17269442158748 0.0945924729438055 no 312 0.120459184628111 678 6769098 SGTC_2639 lactacystin 53 µM 1.17015926228958 0.0950596039927223 no 313 0.120968441677109 674 3870 A proteasome inhibitor. SGTC_2076 5212012 200 µM 1.16999019282775 0.0950908172341459 no 314 0.121002457768212 539 604802 SGTC_2426 5582046 32.21 µM 1.1693150580404 0.0952155344280229 no 315 0.121138359246327 661 2251934 SGTC_335 4077-0256 27.6 µM 1.16830778624814 0.0954018309125353 no 316 0.121341317877561 732 3121989 SGTC_1509 1326-1131 80 µM 1.16612553506041 0.095806361761367 no 317 0.121781846953617 610 768313 SGTC_3004 9076122 71.4286 µM 1.16604789777959 0.0958207768393986 no 318 0.121797540194246 647 44782551 SGTC_2756 carbadox 75.1 µM 1.16588665734573 0.095850719788868 no 319 0.12183013712874 658 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_63 0099-0242 26.702 µM 1.16519047825449 0.095980081851031 no 320 0.121970949505047 709 3898502 YLR359W ADE13 SGTC_360 0957-0399 1.01 µM 1.16495100643211 0.0960246095030664 no 321 0.12201941258686 684 6752301 YPR165W RHO1 SGTC_1830 st055982 50.3 µM 1.16371499062691 0.0962546771814111 no 322 0.122269766169456 648 455313 An antimicrobial agent. SGTC_279 1273-0055 2.93 µM 1.16283800865139 0.0964181611013775 no 323 0.122447616402822 710 2847562 SGTC_2439 5492030 7.2 µM 1.16273054720283 0.0964382077139015 no 324 0.122469421854023 626 5722370 SGTC_133 0724-0033 378.92 µM 1.16214816865662 0.0965469019684479 no 325 0.122587642114729 605 280309 SGTC_328 k915-0120 63.5 µM 1.1582892329162 0.0972694026499297 no 326 0.123373011902622 645 6624543 SGTC_1489 4065-0444 182 µM 1.15819047517555 0.097287944781744 no 327 0.123393157211963 625 2877968 SGTC_1201 1889-3372 45.9 µM 1.1573189277348 0.0974516934868621 no 328 0.123571041594406 634 5392199 SGTC_116 0155-0182 31.788 µM 1.15659387422118 0.0975880724858126 no 329 0.123719163094175 787 771486 SGTC_598 3937-0236 20.2 µM 1.15627119621238 0.0976488116152434 no 330 0.123785123082008 720 1379313 SGTC_490 phenamil 164 µM 1.15624470781074 0.0976537988767998 no 331 0.123790538782341 545 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2303 7774051 200 µM 1.15239509060507 0.0983805958613125 no 332 0.124579378735424 623 2953184 SGTC_1432 4049-0298 68.4 µM 1.15012831342621 0.0988104058055863 no 333 0.125045513198503 642 741646 SGTC_1413 3910-0535 34.4 µM 1.14978945840011 0.0988747749280843 no 334 0.125115299037745 689 2876951 SGTC_2953 9074162 66.49 µM 1.14561174620812 0.099670898143689 no 335 0.125977917437368 601 16451992 SGTC_478 N-arachidonylglycine 10 µM 1.139262460829 0.100889798362496 no 336 0.12729685030956 538 5283389 SGTC_2444 5485484 36.41 µM 1.13866885716523 0.101004308198906 no 337 0.127420648401652 704 6790631 SGTC_1643 st009866 20.2 µM 1.13841605804593 0.10105310347498 no 338 0.127473395944077 655 3156273 YOR207C RET1 SGTC_3291 9121177 71.43 µM 1.13577288381186 0.101564318172098 no 339 0.128025814200045 574 17015612 SGTC_3214 9129694 49.47 µM 1.13468768764121 0.101774749747254 no 340 0.128253098949037 644 17158655 SGTC_553 k007-0256 45.7 µM 1.13339622989961 0.102025591124474 no 341 0.128523948308218 679 6287000 SGTC_359 0081-0058 15.9 µM 1.13219250481327 0.102259796867154 no 342 0.128776755272564 633 3494159 SGTC_1283 0922-0125 16.4 µM 1.1282125545865 0.103036949266637 no 343 0.129615081538173 719 3360884 SGTC_2158 5657123 3.6195 µM 1.12494975689844 0.103677258651848 no 344 0.130305162777497 681 2858827 SGTC_2648 atorvastatin 78.68 µM 1.12321142740735 0.104019574498591 no 345 0.130673855209776 663 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_181 1447-1644 8.07 µM 1.12156277603041 0.104344987247997 no 346 0.131024193061152 684 534600 SGTC_2476 5806916 10.51 µM 1.11901847869157 0.104848630430264 no 347 0.131566127908744 660 2870194 SGTC_2372 9071633 200 µM 1.11868762381898 0.104914252195065 no 348 0.131636713442601 757 21321366 SGTC_2048 5246248 200 µM 1.11834066789917 0.104983099376483 no 349 0.13171076208896 662 677046 SGTC_1710 st031758 61.5 µM 1.11610941484679 0.105426633081967 no 350 0.132187651315899 667 5394341 SGTC_1644 st010134 20.9 µM 1.11353964634858 0.105939135256784 no 351 0.132738365395081 665 3818134 SGTC_3327 9140648 26.9345 µM 1.11056971229273 0.10653368446864 no 352 0.133376802889973 660 8029710 SGTC_2935 9038016 29.96 µM 1.11003711667002 0.106640558670265 no 353 0.133491516317991 734 6463195 SGTC_257 daunorubicin 18.5 µM 1.10984362253897 0.106679405655441 no 354 0.133533208967257 688 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_32 0928-0142 34.1 µM 1.10936754061825 0.106775030053624 no 355 0.133635829612933 676 2244242 SGTC_941 3237-0776 460 µM 1.10918808403517 0.106811091215972 no 356 0.133674525996057 660 760008 SGTC_1600 coumarin 106 71.1 µM 1.106959919044 0.107259565150658 no 357 0.13415562889256 715 100336 A hepatotoxic, DNA x-linker. SGTC_1344 1488-0097 29.1 µM 1.1066776567316 0.107316474244498 no 358 0.134216659431506 674 747966 SGTC_2395 5646831 180.19 µM 1.10474200076631 0.107707323400401 no 359 0.13463569924556 717 6808628 SGTC_1995 st072814 61.1 µM 1.10317458799828 0.108024567221297 no 360 0.134975677327922 681 5769371 SGTC_195 4234-0266 16.654 µM 1.10289454974063 0.108081317638749 no 361 0.135036480688844 754 2303354 SGTC_2650 prasterone 100 µM 1.10138088651809 0.108388436661828 no 362 0.135365460268031 616 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2840 9008771 71.43 µM 1.099285408748 0.10881464027754 no 363 0.135821797393394 653 2992978 SGTC_1011 4112-3381 17.4 µM 1.09697498401488 0.109285957670596 no 364 0.136326163901419 711 2877139 SGTC_1971 st069429 63.5 µM 1.0965166082397 0.109379638580008 no 365 0.136426379626719 685 1246522 YGL099W LSG1 SGTC_1139 k015-0024 46.9 µM 1.09490381021506 0.109709713943221 no 366 0.136779389812106 719 2766652 SGTC_2360 9040895 200 µM 1.09477183676817 0.109736755254982 no 367 0.136808303851795 647 4914414 SGTC_564 3555-0129 330 µM 1.09408311773845 0.109877951173159 no 368 0.136959262977995 630 563260 SGTC_2790 5423970 71.43 µM 1.09123285883528 0.110463675762825 no 369 0.137585216364014 757 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1715 st032160 10.2275 µM 1.09082855077048 0.110546941501959 no 370 0.137674165490404 686 5289825 SGTC_587 k089-0003 57 µM 1.09079903101877 0.110553022746709 no 371 0.137680661471497 568 9659696 SGTC_80 0159-0065 512.242 µM 1.090511434161 0.110612281961869 no 372 0.137743959662421 612 1548079 SGTC_278 4092-0821 23.9 µM 1.08895442795161 0.110933497741804 no 373 0.138086991311781 720 877900 SGTC_327 1273-0057 3.96 µM 1.08844911442699 0.111037889152078 no 374 0.138198444511904 682 3108138 SGTC_2641 levomentholum 100 µM 1.08753739829173 0.11122641617273 no 375 0.138399689999998 680 16666 SGTC_378 3970-0959 8.33 µM 1.08566500961959 0.111614311914136 no 376 0.13881361328903 722 6615653 SGTC_712 r015-0009 80.6 µM 1.08442541969567 0.111871645016094 no 377 0.139088109049593 660 6813872 YLR060W FRS1 SGTC_939 1165-0479 45.3 µM 1.08249314037812 0.112273622921016 no 378 0.139516730901755 725 1377347 SGTC_882 0843-0131 351 µM 1.08188115031537 0.11240115203269 no 379 0.139652670819351 774 5425421 SGTC_1207 2099-0101 141 µM 1.07957635929614 0.112882363023478 no 380 0.140165436752536 763 5837381 SGTC_891 0929-0073 133 µM 1.0736422521164 0.114128091872833 no 381 0.141491526384626 737 5603632 SGTC_1698 5-fluorocytosine 1.055 µM 1.07361104739087 0.114134668363445 no 382 0.141498522072336 735 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_254 nsc-64875 3.808 µM 1.06880529267953 0.115150719641358 no 383 0.142578706977483 742 56993 SGTC_111 0083-0039 52.457 µM 1.06760616737688 0.115405242822853 no 384 0.142849100229946 600 759313 SGTC_2870 9038528 12.99 µM 1.06674766230834 0.115587712267759 no 385 0.14304289908112 653 6463316 SGTC_842 0271-0008 11.1 µM 1.06082448657152 0.116852229747544 no 386 0.144384835957188 798 1221709 SGTC_1143 3454-2408 5.08 µM 1.06078847569713 0.116859947451042 no 387 0.144393020335316 705 X1143 SGTC_502 l-744,832 89.3 µM 1.06071491032927 0.116875714803135 no 388 0.144409740889623 751 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2369 9071472 200 µM 1.05928214525562 0.117183101746003 no 389 0.144735651946364 759 17296037 SGTC_2707 st078556 66.6 µM 1.05765913581543 0.11753199522876 no 390 0.145105435859164 738 17250899 SGTC_2638 epoxomicin 18 µM 1.05610994407792 0.117865705749237 no 391 0.145458993888125 789 9915668 A protesome inhibitor. SGTC_1162 k048-0130 20.1 µM 1.05316173672598 0.118502628131309 no 392 0.146133435911398 752 6797406 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.05297301293714 0.118543482164881 no 393 0.146176680431841 759 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3168 9103419 49.47 µM 1.05183954412675 0.11878905954521 no 394 0.14643658640876 670 16649256 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.05160616427341 0.118839668212167 no 395 0.146490139224872 794 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1760 st045453 10.4495 µM 1.05107864854641 0.118954116662806 no 396 0.146611234752591 784 3323419 YIL048W NEO1 SGTC_376 3970-0862 59.1 µM 1.05059217850157 0.119059728913603 no 397 0.146722967435822 773 3135186 SGTC_3042 9091578 49.47 µM 1.04883905344328 0.119440880061654 no 398 0.147126099924766 730 25236497 SGTC_2516 gossypol 71.55 µM 1.04862569794543 0.119487324891359 no 399 0.147175211828673 781 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_424 splitomicin 100 mM 1.04805112221193 0.119612466214706 no 400 0.147307526991079 700 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_945 3381-0768 11.3 µM 1.04704622101344 0.119831553638479 no 401 0.147539130493175 801 1126236 YIL048W NEO1 SGTC_2994 9053520 71.4286 µM 1.04649455131824 0.119951948268377 no 402 0.147666379625437 759 4647384 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.04646342390413 0.119958743956028 no 403 0.147673561721308 790 688751 SGTC_186 3455-3465 67.277 µM 1.04563333897012 0.120140066905587 no 404 0.14786517532951 680 755278 SGTC_2045 5106652 78.05 µM 1.04529068140522 0.120214972982258 no 405 0.147944321599178 765 673349 SGTC_1920 st075728 45.7 µM 1.04477330936623 0.120328134561049 no 406 0.148063876747726 744 3400306 SGTC_1405 3909-7894 12 µM 1.04433938258779 0.120423102518502 no 407 0.148164199076908 758 7104060 SGTC_942 3253-1115 227 µM 1.04234410283785 0.120860463080069 no 408 0.148626085965154 765 46497897 SGTC_661 1304-0007 33.6 µM 1.04062780388369 0.121237565079328 no 409 0.149024160978095 740 3117130 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.04020778987217 0.121329975668835 no 410 0.14912168658153 727 689007 SGTC_2854 9024559 71.43 µM 1.03829924773557 0.121750512886838 no 411 0.149565379408163 715 3163529 SGTC_3073 9114972 49.47 µM 1.03757630741241 0.12191007612079 no 412 0.149733676484883 713 41905075 SGTC_351 caspofungin 25 nM 1.0373114372815 0.121968573485995 no 413 0.149795368604804 888 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1248 0469-0687 58.6 µM 1.03542905991635 0.122384870128127 no 414 0.15023429013242 776 4017482 SGTC_1799 st045822 46.1415 µM 1.03460676860549 0.122567036338617 no 415 0.150426295850342 766 3674992 SGTC_420 mitomycin C 81.9 mM 1.03417430833596 0.122662917671858 no 416 0.150527341261791 763 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1315 1237-0019 3.69 µM 1.03395726968004 0.122711057420778 no 417 0.150578069915582 808 825140 SGTC_2143 5623677 140.463 µM 1.03179082582902 0.123192306795438 no 418 0.15108505896498 747 5375313 SGTC_631 k072-0230 41.5 µM 1.0267150395241 0.124325006798055 no 419 0.152277332693934 816 5773147 SGTC_2576 guaiol 23.12 µM 1.02577432358937 0.124535732170976 no 420 0.152498985808673 822 227829 SGTC_2474 5321570 43.32 µM 1.02419527833483 0.124890007801062 no 421 0.152871524247898 777 2841384 SGTC_2686 alizarin 95.37 µM 1.02073251089658 0.125669380112842 no 422 0.153690593524913 708 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_164 4100-3994 89.624 µM 1.0204718854304 0.125728176637452 no 423 0.153752358189141 849 4615967 SGTC_3064 1327-0027 10 µM 1.02005373701622 0.125822550076705 no 424 0.153851487958409 620 16000455 YPR107C YTH1 SGTC_1796 st049173 110.4 µM 1.01983174421759 0.125872672513576 no 425 0.153904132618601 739 94134 SGTC_3155 9099265 49.47 µM 1.01925591822974 0.126002749747819 no 426 0.154040742893894 725 25236499 SGTC_3289 9119912 71.43 µM 1.01177824821634 0.127700445791135 no 427 0.155822046242043 777 17014829 SGTC_2275 7947463 200 µM 1.00994216785028 0.128119721217298 no 428 0.156261499180806 756 1225414 SGTC_2702 st077768 96.8 µM 1.00930641473998 0.128265120288295 no 429 0.156413852327404 705 6484119 SGTC_877 0771-0151 33.1 µM 1.00891556617789 0.128354565643047 no 430 0.156507564598958 814 6166523 SGTC_1185 1319-0113 81.3 µM 1.00480290664003 0.129298369780208 no 431 0.157495882000965 746 4672763 SGTC_959 1222-0044 107 µM 1.00405365397068 0.129470830578473 no 432 0.157676376382626 811 6083612 SGTC_2025 5147754 141 µM 1.00332682985525 0.129638281071044 no 433 0.157851597539978 791 315777 YLR208W SEC13 SGTC_1060 3448-7350 82 µM 1.00327232377514 0.12965084458201 no 434 0.157864742898122 799 570178 SGTC_1563 conessine 56.1 µM 1.00275502099465 0.129770123522734 no 435 0.157989537800076 908 441082 An anti-amoebic, histamine inhibitor. SGTC_3100 9120536 49.47 µM 0.998893520268365 0.130662903698105 no 436 0.15892313775582 695 16421196 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.994514023057725 0.131680573167348 no 437 0.159986340897158 753 5282362 SGTC_1718 roemerine 11.9335 µM 0.993101051792184 0.132010071054126 no 438 0.160330355739142 819 235224 An aporphine alkaloid with mutagenic activity. SGTC_2564 betulinic acid 100 µM 0.991671456982224 0.132344023702934 no 439 0.16067890952722 870 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2159 5658611 73.75 µM 0.99092078738918 0.132519612703249 no 440 0.160862130525374 837 793844 SGTC_1851 st056236 18.9 µM 0.987180517335473 0.133396890582804 no 441 0.16177707552366 854 5393171 SGTC_2742 clothiapine 36.27 µM 0.986187197564543 0.133630542924437 no 442 0.162020630230429 764 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3201 9113999 49.47 µM 0.984919562108622 0.133929129301425 no 443 0.162331791811628 773 16649224 SGTC_406 estrone 100 µM 0.983898251251221 0.134170028188792 no 444 0.162582771811247 843 5870 A steroid. SGTC_439 amiodarone 34.4 µM 0.982152149855607 0.13458257413553 no 445 0.163012448482212 821 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2866 9034245 58.44 µM 0.981832795491558 0.134658121082378 no 446 0.163091114258961 808 6462273 SGTC_2986 9022445 71.43 µM 0.981667407328126 0.134697256991196 no 447 0.163131863615646 827 6459286 SGTC_2073 5212005 126 µM 0.981594137179301 0.134714597448941 no 448 0.163149918482128 736 691789 SGTC_2627 acetyl isogambogic acid 100 µM 0.980917504282695 0.134874804964242 no 449 0.16331671237051 761 6857789 A caspase activator and apoptosis inducer. SGTC_211 3455-0679 143.504 µM 0.980477331766367 0.13497909549824 no 450 0.163425276872666 841 748649 SGTC_1872 amphotericin b 148 nM 0.979386023728993 0.135237898763445 no 451 0.16369464008709 865 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1450 4112-4260 37.6 µM 0.978371977835623 0.135478684070509 no 452 0.163945191178832 865 1633175 SGTC_2647 atorvastatin 60.16 µM 0.978269770898388 0.135502969405804 no 453 0.163970458329376 813 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_287 k060-0039 29.6 µM 0.976027373861045 0.136036534884302 no 454 0.164525449647014 839 5861974 SGTC_1618 st003135 44.5 µM 0.974822156647867 0.136323902846766 no 455 0.16482424228582 816 1270615 SGTC_2514 salinomycin 42.74 µM 0.972114286509795 0.136971072379091 no 456 0.165496847760969 907 23682228 A polyether potassium ionophore. SGTC_1320 1313-0481 95.3 µM 0.971319271157414 0.137161475730639 no 457 0.165694657596352 863 6813365 YLR208W SEC13 SGTC_1916 st067606 49.2 µM 0.970174968640521 0.137435849398781 no 458 0.16597964274049 872 19590279 SGTC_3129 9127257 49.47 µM 0.96911274570416 0.137690877710067 no 459 0.166244469522674 698 837894 SGTC_846 0335-0850 148 µM 0.96749113537692 0.138080831433628 no 460 0.166649285302743 825 6819598 SGTC_1179 1021-1431 9.29 µM 0.959301097680971 0.14006181722679 no 461 0.168703541280546 879 2840958 SGTC_2261 9010538 184.68 µM 0.957453224800472 0.140511432832934 no 462 0.169169272425667 726 6457250 SGTC_2318 6029776 164 µM 0.956758354721003 0.140680758527015 no 463 0.169344618328521 836 818325 SGTC_3251 9135047 49.47 µM 0.951826376007117 0.141886560224772 no 464 0.170592521507934 846 17682963 SGTC_3310 9130229 44.1445 µM 0.949721995165064 0.142403176549735 no 465 0.171126765281258 835 7761258 SGTC_1989 st071868 50.2 µM 0.948743133997103 0.142643915765745 no 466 0.171375635127621 895 16414057 SGTC_1794 st048918 76.9 µM 0.948337330929313 0.142743798826265 no 467 0.171478876035329 792 672303 SGTC_957 1187-1561 14.1 µM 0.948282684975243 0.142757252816798 no 468 0.171492781622437 839 1538454 SGTC_73 0327-0325 16.231 µM 0.945953109653875 0.143331598217408 no 469 0.172086251555418 938 53298 SGTC_3266 9136860 49.47 µM 0.94573067512661 0.143386519855917 no 470 0.172142986244423 836 4871271 YPR165W RHO1 SGTC_1628 st004252 77.7 µM 0.944551087182789 0.143678011127365 no 471 0.172444054280991 871 692968 SGTC_427 1354-0053 47.3 µM 0.944344701743369 0.143729052685071 no 472 0.172496764852831 835 6813657 SGTC_3150 9097574 49.47 µM 0.941556473309888 0.144419813736759 no 473 0.173209881657698 849 17217476 SGTC_828 2074-0507 139 µM 0.940940352709707 0.144572753932519 no 474 0.173367713456492 881 X828 SGTC_3095 9117207 49.47 µM 0.940499249552489 0.14468231638408 no 475 0.173480767205259 818 17015229 SGTC_1756 st041558 35.5 µM 0.936331743432021 0.145720213360768 no 476 0.174551204618797 953 3955792 SGTC_518 1021-0119 62.6 µM 0.935034624894245 0.146044273218267 no 477 0.174885227842117 808 1097762 SGTC_513 4245-1575 41.7 µM 0.930712883943855 0.147127467904815 no 478 0.176001051639485 957 719745 SGTC_2226 7298446 200 µM 0.929534663797515 0.1474237072564 no 479 0.176306034801883 848 3283010 SGTC_3345 9148410 3.559 µM 0.928780779675229 0.147613465536231 no 480 0.17650135360275 873 4903596 SGTC_3160 9100216 49.47 µM 0.926552241256885 0.14817536162024 no 481 0.177079530627175 890 17191039 SGTC_3105 9121040 49.47 µM 0.926519021749159 0.148183748284956 no 482 0.177088158212054 683 41448907 SGTC_1800 st050079 29.0735 µM 0.926326768728382 0.148232291112808 no 483 0.177138094307514 954 3645560 SGTC_3084 9116877 49.47 µM 0.925161654725847 0.148526703565572 no 484 0.177440913076196 829 27241325 SGTC_2910 7948405 25.97 µM 0.918044653860459 0.150333581945917 no 485 0.179297744262872 853 2971328 SGTC_1751 st044839 27.194 µM 0.9173614692094 0.150507797499274 no 486 0.179476628197409 887 5291326 SGTC_643 k048-0106 28.4 µM 0.916758917729303 0.150661562754623 no 487 0.179634492350247 881 6763920 SGTC_281 1672-3440 14.9 µM 0.915213272207759 0.151056474607764 no 488 0.180039839193239 945 6833000 SGTC_2511 berberine 10.47 µM 0.915109416814596 0.151083034295649 no 489 0.18006709593255 875 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_224 benfluorex 43.875 µM 0.915023291678744 0.151105062053831 no 490 0.180089701349308 864 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1158 4092-0494 91.8 µM 0.913980063864325 0.151372052469197 no 491 0.180363660676225 932 1148199 SGTC_2898 9056270 58.44 µM 0.913534066494749 0.151486291018413 no 492 0.180480862628254 840 19154699 SGTC_1492 4158-0558 28.5 µM 0.912632289842767 0.151717448753287 no 493 0.18071798299558 887 3967268 SGTC_534 k292-0788 63.4 µM 0.912456050050515 0.151762652709396 no 494 0.180764347703249 984 4146317 SGTC_1279 0874-0590 65.2 µM 0.912398389126479 0.151777444172031 no 495 0.180779518608555 900 3523074 SGTC_1354 1498-1681 81 µM 0.911523555488704 0.152001978305479 no 496 0.181009790050159 944 5754243 SGTC_2960 9079389 5.97 µM 0.911433988917565 0.152024978837446 no 497 0.181033375897685 900 16457355 SGTC_3271 9137798 49.47 µM 0.910908099065385 0.152160073021893 no 498 0.181171898972019 821 6498326 SGTC_896 0964-0007 44.5 µM 0.907298738178163 0.153089420873043 no 499 0.182124420640524 941 6756758 SGTC_1246 0422-0085 105 µM 0.907251945823302 0.153101493744723 no 500 0.182136789809773 933 264295 SGTC_1587 estradiol valerate 56.1 µM 0.905173773936731 0.153638318202374 no 501 0.182686666716081 933 13791 A steroid. SGTC_2237 6667747 47.222 µM 0.904409967891671 0.153835934139352 no 502 0.182889027302388 846 729940 YDL015C TSC13 SGTC_2038 4100038 30.985 µM 0.902561075033731 0.154314985679189 no 503 0.183379446573535 882 3596803 SGTC_79 0052-0007 94.094 µM 0.901267890514076 0.154650637816609 no 504 0.183722950884563 916 2801472 SGTC_292 k038-0015 474 µM 0.900551557778678 0.154836772840449 no 505 0.183913400385122 889 46368540 SGTC_109 0132-0036 33.701 µM 0.900442917422061 0.154865015343649 no 506 0.183942295044331 789 67274 A color developer. SGTC_2717 st081029 62.2815 µM 0.898894412008647 0.155267939781382 no 507 0.184354452351475 900 5292846 SGTC_2305 7443522 69.23 µM 0.898120495864823 0.155469573516131 no 508 0.184560656598089 945 5415886 SGTC_2836 9010338 19.48 µM 0.897457062517783 0.155642559866356 no 509 0.184737537654558 869 2994051 SGTC_762 1165-0429 115 µM 0.897271900748827 0.155690862361543 no 510 0.184786923301283 920 5967793 SGTC_3164 9100705 49.47 µM 0.895036396578959 0.156274810534071 no 511 0.185383815996765 904 17174235 SGTC_1927 st060202 13.8 µM 0.893112373516007 0.156778548798773 no 512 0.185898498674482 920 688887 SGTC_1498 4478-3555 97.6 µM 0.892890100615941 0.156836811975574 no 513 0.185958014471188 895 3437919 SGTC_2915 7971052 15.16 µM 0.892703883998708 0.156885634883423 no 514 0.186007884930846 765 5741558 SGTC_2946 9065502 71.43 µM 0.890748343805764 0.157398948922665 no 515 0.186532096547215 757 16489101 SGTC_2973 9094665 17.96 µM 0.888818177504776 0.157906683843279 no 516 0.187050402522366 966 25237061 YIL048W NEO1 SGTC_2129 girgensonine 121.053 µM 0.88848540500632 0.157994329027529 no 517 0.187139851602959 966 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2669 eugenol 100 µM 0.887785519452905 0.158178768171212 no 518 0.187328066803029 885 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1096 rimcazole 32.2 µM 0.88734104033595 0.158295974012081 no 519 0.1874476581214 864 18528119 A dopamine reuptake inhibitor. SGTC_1482 3346-2049 8.48 µM 0.886805041452919 0.158437388706913 no 520 0.187591936447104 913 3826804 SGTC_1208 2323-2347 50.3 µM 0.88349087193414 0.159313618848343 no 521 0.188485556121111 950 5412760 SGTC_2744 captopril 92.04 µM 0.882976153896014 0.159449988812064 no 522 0.188624577815702 886 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.882345908077035 0.159617070873771 no 523 0.188794888810591 777 4000243 SGTC_314 1671-0008 2.74 µM 0.881187809544923 0.159924388555376 no 524 0.189108088132917 946 3913060 SGTC_1380 2291-0730 164 µM 0.880708025005439 0.160051819407764 no 525 0.189237936060153 868 2999191 SGTC_2814 7977482 42.97 µM 0.879297397519985 0.160426866765528 no 526 0.189620023304816 977 6456762 SGTC_1108 betulinic acid 729.144 nM 0.879266224577292 0.160435161280302 no 527 0.189628472267819 938 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1688 st021091 57.6 µM 0.87752967773079 0.160897665244007 no 528 0.190099503219727 964 3656366 SGTC_467 ro 31-8220 72.8 µM 0.876720199294754 0.161113555162153 no 529 0.190319316292455 927 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.876430650547993 0.16119082441197 no 530 0.190397980864828 966 5282309 SGTC_819 1013-0258 27.7 µM 0.87619932591518 0.161252573290701 no 531 0.190460841463033 934 5753198 SGTC_1908 st060353 56.5 µM 0.875083314101934 0.161550693820932 no 532 0.190764287660825 994 4227716 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.872100975624376 0.162349128670947 no 533 0.191576646982791 1003 688761 SGTC_1115 galangin 695.678 nM 0.871698786759476 0.162456999325331 no 534 0.191686361155626 1030 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1540 guanosine 70.6 µM 0.86864823364031 0.163276703181499 no 535 0.192519781897912 899 6802 Guanosine is a purine nucleoside SGTC_38 0929-0051 58.268 µM 0.868369136164952 0.163351832467175 no 536 0.19259614265343 1001 1379719 SGTC_539 4859-0462 2.54 µM 0.866245020111948 0.163924351636792 no 537 0.193177904785312 975 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.866211531647989 0.163933388292942 no 538 0.193187085332174 841 88881 An O-methylated flavonoid and antioxidant. SGTC_354 2783-3500 4.88 µM 0.865978217135228 0.163996355750898 no 539 0.193251053698437 909 6740761 SGTC_2443 5493264 126.67 µM 0.864315272223335 0.164445609578241 no 540 0.193707361390748 963 5340055 SGTC_200 k038-0079 37.545 µM 0.862186267627093 0.165021935335963 no 541 0.194292512603139 940 3436683 SGTC_2032 5185112 25.99 µM 0.862128397729492 0.165037619066677 no 542 0.194308433001133 913 5718189 SGTC_1508 1080-0625 72.9 µM 0.860704218316214 0.165423900119379 no 543 0.194700484612838 917 767111 SGTC_462 ag-879 158 µM 0.860026843696237 0.165607829943142 no 544 0.194887122724705 1000 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_152 4469-0003 551.229 µM 0.859899652565759 0.165642381324095 no 545 0.194922180029136 974 697280 SGTC_1347 1493-0251 600 nM 0.859825412060474 0.165662550859398 no 546 0.194942644486086 1016 3986378 SGTC_2753 fluvastatin 17.09 µM 0.859387877953769 0.16578145164566 no 547 0.195063277661593 942 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_3211 9128781 49.47 µM 0.859278437713798 0.165811200877669 no 548 0.195093458685372 877 17194361 SGTC_475 α-linolenic acid 10 µM 0.859002995829668 0.165886089747279 no 549 0.195169431588567 1028 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3106 9121286 49.47 µM 0.858221192648522 0.166098770374531 no 550 0.195385167951074 923 15943471 SGTC_3339 9145883 14.936 µM 0.857192140961764 0.166378980557991 no 551 0.1956693525595 897 2030670 SGTC_3173 9105693 49.47 µM 0.857111253288456 0.166401019156915 no 552 0.195691701264861 999 17096658 SGTC_5 0352-0601 109.883 µM 0.856863702215818 0.166468478459931 no 553 0.195760107543434 919 762456 SGTC_1490 4089-0339 670 nM 0.856680000918765 0.166518549687753 no 554 0.195810879467022 934 742542 SGTC_775 4577-0580 57.3 µM 0.85245508154529 0.167672813031334 no 555 0.196980779849915 977 2006902 SGTC_1817 st052116 64.4 µM 0.851688324746231 0.167882844916057 no 556 0.197193551183279 950 4361398 SGTC_1948 st076329 66.6 µM 0.851085127689352 0.168048193094106 no 557 0.197361033156237 913 24208413 SGTC_1141 3253-0389 52.6 µM 0.850841431476646 0.168115024732636 no 558 0.197428721543589 980 5402031 SGTC_2649 anisomycin 9.56 µM 0.848862859593937 0.168658264417631 no 559 0.197978803720121 954 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2119 5528445 120.635 µM 0.848236340677821 0.168830517337771 no 560 0.198153181172705 967 791935 SGTC_2890 9046729 58.44 µM 0.848175611469791 0.168847220021146 no 561 0.198170088710516 893 903329 SGTC_1088 bifonazole 369 nM 0.84782911061765 0.16894254033867 no 562 0.198266574210819 948 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2077 5212015 200 µM 0.84767910742296 0.168983816042077 no 563 0.198308352405441 924 780900 SGTC_2771 fluoxetine 41.05 µM 0.845511891878838 0.169580881712833 no 564 0.198912547955875 944 3386 A selective serotonin reuptake inhibitor. SGTC_1701 st028638 40.4 µM 0.844738053172965 0.169794400991806 no 565 0.199128554091208 1002 3490878 SGTC_1078 idebenone 36.1 µM 0.840306952943446 0.171020357979008 no 566 0.200368151996824 1004 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1414 3917-0015 5.4 µM 0.839593452673483 0.171218290794192 no 567 0.200568185747208 994 6618702 SGTC_2551 apiole 73.87 µM 0.839200836200314 0.171327269370236 no 568 0.200678309077475 867 10659 A possible DNA adduct former. SGTC_2761 levamisole 97.89 µM 0.837892187740585 0.171690831129798 no 569 0.201045628375889 972 26879 An alkaline phosphatase inhibitor. SGTC_1795 st049545 62.3 µM 0.837332901492366 0.171846359271498 no 570 0.201202735122573 993 5291882 SGTC_2483 5729050 27.16 µM 0.835820224950906 0.172267459869138 no 571 0.201628023370664 1048 2865180 SGTC_435 c-PAF 6.7 µM 0.835283974368439 0.172416899848959 no 572 0.201778919145253 983 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1917 st066507 28.5 µM 0.835280654844333 0.172417825176942 no 573 0.201779853438077 988 3156428 SGTC_33 0986-0033 35.816 µM 0.832759630148454 0.17312148348692 no 574 0.202490153363025 972 2848082 SGTC_2166 5933061 31.504 µM 0.832564749011572 0.173175953985648 no 575 0.202545123392804 1092 2877375 SGTC_659 k018-0002 107 µM 0.831855092375592 0.173374399689822 no 576 0.202745371278196 1003 6797879 YHR007C ERG11 SGTC_852 0418-0143 439 µM 0.829265870006258 0.174099667099991 no 577 0.203476989548884 1072 5369229 SGTC_1682 st012968 530 nM 0.828369705961407 0.174351140344019 no 578 0.203730578708452 915 24207270 SGTC_2266 7929956 200 µM 0.82796518762348 0.174464728084977 no 579 0.203845107686569 1026 2967153 SGTC_2852 9023854 51.95 µM 0.824071223283754 0.175560546592788 no 580 0.204949544989738 999 19798528 SGTC_2281 7943571 200 µM 0.823789101545584 0.175640108881674 no 581 0.20502970058471 1094 1244024 SGTC_2080 5212524 12.4 µM 0.823042911111206 0.175850655163083 no 582 0.205241795808189 989 260183 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.822188968026338 0.176091801163844 no 583 0.205484678241121 865 6708630 An antioxidant. SGTC_2585 alliin 100 µM 0.821765530035107 0.176211453921639 no 584 0.205605177698401 1023 87310 A garlic compound which reacts with lipids. SGTC_2741 miltefosine 3.04 µM 0.819797086132692 0.176768361252472 no 585 0.206165896227307 922 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_699 0375-0592 111 µM 0.818294282083834 0.177194279030136 no 586 0.206594585147182 1059 762578 SGTC_2167 5876490 200 µM 0.817180967444727 0.177510227116465 no 587 0.206912508728681 1031 686534 SGTC_336 4111-0029 111 µM 0.816469332120426 0.177712368610445 no 588 0.207115878405777 956 3131175 SGTC_1882 5615643 20 µM 0.81357632177131 0.178535628715209 no 589 0.207943853544102 998 2253075 SGTC_2566 crystal violet carbinol 226 nM 0.813420861471732 0.178579935748697 no 590 0.207988401304367 933 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_766 1391-0721 126 µM 0.81327679786947 0.178621000842724 no 591 0.20802968832547 1027 1020919 YIL115C NUP159 SGTC_3246 9135460 32.98 µM 0.813045777921068 0.178686865113649 no 592 0.208095906163911 972 41446951 SGTC_2921 7974240 10.71 µM 0.812767796773301 0.178766138388674 no 593 0.208175601099539 996 2979074 YDR527W RBA50 SGTC_2114 5491910 81.25 µM 0.811624019087046 0.179092548110371 no 594 0.208503702324899 1013 2849228 SGTC_1044 1222-0021 1.78 µM 0.810584663707881 0.179389482880096 no 595 0.208802113493917 981 4306703 SGTC_3292 9120825 59.784 µM 0.810229439788288 0.179491038188626 no 596 0.208904160139693 1051 24824900 SGTC_3069 9117009 49.47 µM 0.806515841654348 0.180554885150379 no 597 0.209972738744441 919 41904981 SGTC_774 k060-0086 136 µM 0.803691746716581 0.181366554722199 no 598 0.210787510896735 1101 5911235 SGTC_1878 temozolomide 1 mM 0.802518130665073 0.181704533160446 no 599 0.211126652449171 1020 5394 DNA alkylating agent. SGTC_2941 9056145 11.23 µM 0.800672209330105 0.182236919092251 no 600 0.211660717584687 964 2119517 SGTC_2024 5144227 134 µM 0.798868140457829 0.182758175204193 no 601 0.212183437156672 1060 3475211 SGTC_1292 0kpi-0043 232 µM 0.798688032057034 0.182810265624258 no 602 0.212235664028428 1006 3333905 SGTC_2300 7976697 71.57 µM 0.797936149048225 0.183027823094246 no 603 0.212453772191309 932 2236109 SGTC_394 menadione 8.33 µM 0.797780258317603 0.183072950312587 no 604 0.212499009760886 1025 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3219 9131112 49.47 µM 0.797191306842825 0.183243502513445 no 605 0.212669967001322 1002 17612988 YMR079W SEC14 SGTC_862 0452-0056 10.2 µM 0.797025788211659 0.183291452251035 no 606 0.212718027192664 1013 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3202 9113761 49.47 µM 0.794553360845322 0.184008630442666 no 607 0.21343667869061 1076 4798415 SGTC_2308 7584454 197.62 µM 0.793509983914542 0.184311806813638 no 608 0.213740377387829 1069 893577 SGTC_1758 st042942 75.2445 µM 0.793110107565768 0.184428082119277 no 609 0.213856837219526 1056 669317 SGTC_2338 7999974 200 µM 0.791983049385561 0.184756051496369 no 610 0.214185279969045 1119 315925 SGTC_2 0422-0095 29 µM 0.783531123999125 0.187227066983143 no 611 0.21665764203428 984 6790840 SGTC_2828 7998861 71.43 µM 0.782086671914839 0.187651404387155 no 612 0.217081819490285 991 2988188 SGTC_1216 1165-0504 9.65 µM 0.780903426500232 0.187999449310394 no 613 0.217429648317048 1068 6304004 SGTC_2285 7945142 200 µM 0.779225291212182 0.188493746146989 no 614 0.217923507156985 1050 2970608 SGTC_562 3772-2733 112 µM 0.775791790935766 0.189507582423058 no 615 0.218935965864429 1115 2876874 YIL048W NEO1 SGTC_2799 7812892 81.82 µM 0.775343933843328 0.189640071600871 no 616 0.219068227612662 1072 20205235 SGTC_622 1348-1566 26.3 µM 0.775155291341258 0.189695894600279 no 617 0.21912395151525 1123 7340407 SGTC_2967 9089538 49.85 µM 0.775114165838461 0.189708065781245 no 618 0.21913610083254 1100 728216 SGTC_50 0929-0078 56.389 µM 0.774178765252945 0.189985029285541 no 619 0.219412541924741 991 1377751 SGTC_114 0364-0001 490.298 µM 0.77337575627351 0.190222991017618 no 620 0.219650016775808 1080 4003655 SGTC_1892 st058411 7.36 µM 0.771517726791898 0.190774296592007 no 621 0.220200059640595 1091 3934738 SGTC_1120 ficusin 1.78878 µM 0.770487606001468 0.19108037112216 no 622 0.22050535211197 1086 6199 A DNA cross-linker. SGTC_875 0709-0210 25.7 µM 0.769241620519679 0.191450986566191 no 623 0.220874943384609 1148 6251364 SGTC_1558 st069300 45.6 µM 0.766951223860651 0.192133407661692 no 624 0.221555258173149 1025 24208000 SGTC_790 1575-0012 79.1 µM 0.766931005707108 0.192139438256643 no 625 0.22156126888401 1129 378741 YLR208W SEC13 SGTC_2123 5259487 200 µM 0.766213235475428 0.192353607095039 no 626 0.22177471716424 1092 2173474 SGTC_3343 9148379 18.9835 µM 0.764135161368781 0.192974487148314 no 627 0.222393350314977 1130 1955036 SGTC_130 0136-0219 337.655 µM 0.76352470980976 0.193157108143502 no 628 0.222575265819621 1065 234244 SGTC_2934 9036370 36.88 µM 0.763166387234723 0.193264352052288 no 629 0.222682086001719 1109 6462800 SGTC_1525 8-methoxypsoralen 92.5 µM 0.76072046000077 0.1939973743942 no 630 0.223412025782493 1140 4114 Related to psoralen; DNA damaging agent. SGTC_2792 7535235 81.82 µM 0.760201112331113 0.194153235972301 no 631 0.223567190105072 1048 1281891 SGTC_2978 9011784 42.97 µM 0.759797516479952 0.194274411892404 no 632 0.223687813830575 1173 2994934 SGTC_1798 st045719 60.953 µM 0.759768489856476 0.194283128642406 no 633 0.223696490517981 1059 3980186 SGTC_2620 irigenin 100 µM 0.75662881832035 0.195227383533873 no 634 0.224636135532444 1113 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_647 0140-0236 81 µM 0.756004310274641 0.195415536050708 no 635 0.224823305720598 1147 990837 SGTC_27 0485-0001 32.618 µM 0.755777670358622 0.195483845621316 no 636 0.224891253424989 1041 2054479 SGTC_2156 5649887 115 µM 0.75499220800702 0.195720697212396 no 637 0.22512682876559 1158 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_188 3229-0966 278.469 µM 0.754230795928084 0.195950462782454 no 638 0.225355324354336 1217 5722370 SGTC_702 1488-0190 94 µM 0.753792997203035 0.196082648062826 no 639 0.225486764787096 1112 949357 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.749939881955575 0.197248356534536 no 640 0.226645456578525 1078 756377 SGTC_2201 6605497 169.863 µM 0.74809455334929 0.197808117595782 no 641 0.22720156354158 1116 670741 SGTC_2133 5320837 200 µM 0.747158944590332 0.198092290994547 no 642 0.227483811499881 1080 2841355 SGTC_2346 9031566 143.75 µM 0.746562380741663 0.198273614569078 no 643 0.227663881796275 1090 4771086 SGTC_588 3970-1144 52.9 µM 0.746099754126072 0.198414297313775 no 644 0.227803578925246 1062 1888707 SGTC_1636 st007707 68.9 µM 0.746093978119825 0.198416054152789 no 645 0.227805323382857 1140 403051 SGTC_1010 4112-3296 15.2 µM 0.745341051469016 0.198645145839032 no 646 0.228032785103687 1160 704384 SGTC_451 chloral hydrate 100 µM 0.744784938658792 0.198814455696253 no 647 0.228200870674115 1172 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1841 st054148 70 µM 0.7444110150013 0.198928346532815 no 648 0.228313928570272 1067 675442 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.740376295889106 0.200159753371721 no 649 0.229535848920747 1145 165506 SGTC_1423 4048-0112 5.59 µM 0.739914257852391 0.200301060363111 no 650 0.229676011238787 1137 X1423 SGTC_1084 voriconazole 435 nM 0.739823475473629 0.200328831754775 no 651 0.229703556312223 1149 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1742 st038235 28.8875 µM 0.736438369252808 0.201366025926134 no 652 0.230731980695385 1095 564103 YBR002C RER2 SGTC_1133 3473-0247 50 µM 0.735635935582481 0.201612362154372 no 653 0.230976143517726 1102 711311 SGTC_1793 st048256 72.231 µM 0.73469872546575 0.201900301356193 no 654 0.231261498355097 1087 672022 SGTC_3024 9090631 49.47 µM 0.734488226937736 0.201965006690469 no 655 0.231325616432222 1107 25236383 SGTC_1348 1493-0373 93.8 µM 0.733627885721435 0.202229596774778 no 656 0.23158778034023 1116 3010129 SGTC_683 panaxydol 45 µM 0.733484077688056 0.202273843840877 no 657 0.231631617795098 1131 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1098 clofazimine 15.1 µM 0.733367690200818 0.202309658352713 no 658 0.231667099944436 1145 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2583 asiatic acid 100 µM 0.733134824535395 0.202381326668388 no 659 0.231738100983141 1166 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_56 0957-0365 83.25 µM 0.731901366315953 0.202761197259603 no 660 0.232114386090837 1121 6752360 SGTC_2629 bisabolol 100 µM 0.731513094890876 0.202880862089198 no 661 0.232232904508574 1137 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1977 st070720 65.3 µM 0.72911419361603 0.203621135860325 no 662 0.232965906526446 1114 682188 SGTC_3131 9127911 49.47 µM 0.726715821075506 0.204362854320227 no 663 0.23370002975685 1172 45595681 SGTC_1546 5-methoxyflavanone 78.7 µM 0.725697480981281 0.204678271062304 no 664 0.234012123193202 1177 147795 SGTC_501 nsc-95397 161 µM 0.724524652641661 0.205041897003807 no 665 0.234371848932175 1143 262093 SGTC_1980 st071811 45.7 µM 0.724330316987925 0.205102186263892 no 666 0.234431484413048 1168 4974850 SGTC_3286 9117135 37.221 µM 0.722865314940801 0.205557016662557 no 667 0.234881317431306 1132 3438150 SGTC_1235 benzylparaben 21.5 µM 0.721327126230129 0.206035212726267 no 668 0.235354135548837 1133 7180 SGTC_1903 st060211 78.3 µM 0.719946527413278 0.206464978120115 no 669 0.235778959699358 1177 688960 SGTC_1306 1185-0270 9.02 µM 0.719312477916559 0.206662528662897 no 670 0.235974204697385 1169 1548076 SGTC_2117 5521686 200 µM 0.717564713435151 0.207207658139911 no 671 0.236512860729811 1164 803312 SGTC_3217 9129673 49.47 µM 0.716953651591462 0.207398449399002 no 672 0.236701347772035 1149 17248312 SGTC_228 caffeine 993.056 µM 0.714634047839087 0.208123641855211 no 673 0.237417600153915 1158 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1969 st069479 40.1 µM 0.713991496758981 0.208324791063283 no 674 0.237616218754499 1138 3895485 SGTC_3090 9117696 49.47 µM 0.71280459634369 0.208696649062618 no 675 0.237983340508026 1137 7923821 SGTC_2262 9014885 67.46 µM 0.712605950153503 0.208758923460631 no 676 0.23804481438785 1117 6457424 SGTC_1703 st026983 48.3 µM 0.712597966782307 0.208761426428846 no 677 0.23804728513716 1178 1104023 SGTC_2646 retinol 96.75 µM 0.710656095799821 0.209370772255196 no 678 0.238648686228172 1187 445354 A vitamin A analog and teratogen. SGTC_3237 9133362 49.47 µM 0.709478479506222 0.209740809459769 no 679 0.239013800816816 1131 43845137 SGTC_2229 7354935 190 µM 0.709386480233462 0.209769734172402 no 680 0.23904233762922 1139 318112 SGTC_2518 prenyletin 46.28 µM 0.708676765859925 0.209992948276786 no 681 0.23926254311428 1101 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1641 st009299 47.1 µM 0.707363439951413 0.210406373716564 no 682 0.239670325334565 1141 4046054 SGTC_1814 st052110 31.539 µM 0.70579703900093 0.210900089605605 no 683 0.240157181862946 1154 674163 SGTC_2219 9098279 200 µM 0.704880033360204 0.211189436741474 no 684 0.240442448367605 1175 902349 SGTC_158 k038-0087 26.446 µM 0.700139971371272 0.212688795387703 no 685 0.241919947753093 1157 X158 SGTC_1382 3002-2117 298 µM 0.699837199105243 0.212784777899217 no 686 0.242014490339309 1233 1497314 SGTC_2125 5246583 200 µM 0.698718391079056 0.213139673010332 no 687 0.242364019103064 1227 835267 SGTC_1921 5740136 50 µM 0.698462423360616 0.213220916580102 no 688 0.242444024854381 1191 1774243 SGTC_2671 danthron 100 µM 0.697587964663924 0.213498603973876 no 689 0.242717455204287 1163 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1097 itavastatin 7.23 µM 0.697298670288613 0.213590516782178 no 690 0.242807950027213 1226 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2350 9023895 38.85 µM 0.692714534807657 0.215050034137381 no 691 0.244244357893159 1209 2997209 SGTC_953 1188-0045 9.7 µM 0.692439937746432 0.215137645007426 no 692 0.244330546210803 1184 6144426 SGTC_2342 7990637 118.86 µM 0.692431210703469 0.215140429731695 no 693 0.244333285653613 1237 2033102 YER133W GLC7 SGTC_2415 st077333 57.7 µM 0.691887167124702 0.215314070660978 no 694 0.244504095109242 1235 2766255 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.691544134480081 0.215423597260384 no 695 0.244611827663875 1246 94937 An inhibitor of serotonin biosynthesis. SGTC_918 glabranin 770.725 nM 0.691298095903034 0.215502174607656 no 696 0.244689114081257 1219 124049 Also referred to as licorice root. SGTC_940 3232-1287 54.8 µM 0.690678011300945 0.215700284772877 no 697 0.244883955333709 1177 1585493 YIL048W NEO1 SGTC_1140 3229-1848 2.98 µM 0.690504425550121 0.215755762407903 no 698 0.244938513918194 1207 2849525 SGTC_2634 4'-methoxyflavone 100 µM 0.687429370207486 0.216739913719096 no 699 0.245906097435829 1188 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2525 harmine 47.85 µM 0.687095380368175 0.216846961047508 no 700 0.246011312580363 1169 5280953 A monoamine oxidase inhibitor SGTC_3195 9113082 49.47 µM 0.686976331101928 0.216885125003371 no 701 0.246048821911879 1172 17018038 SGTC_1741 st038134 10.228 µM 0.686039870198917 0.21718546426037 no 702 0.24634398337357 1259 1272587 SGTC_2948 9070189 9.45 µM 0.684464302396978 0.217691317966532 no 703 0.246841011788074 1130 6473636 YDL196W YDL196W SGTC_1445 4239-0156 97.7 µM 0.684131491190195 0.217798257631405 no 704 0.246946068996209 1257 4008346 SGTC_1086 cerivastatin 2.18 µM 0.682067866208621 0.21846202248225 no 705 0.247598019211277 1184 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1922 5578187 25 µM 0.681787611140814 0.218552256270569 no 706 0.247686629580919 1235 1350412 SGTC_3277 9138724 49.47 µM 0.680760365608623 0.21888318217193 no 707 0.248011566340691 1136 15943418 SGTC_2963 9082507 9 µM 0.68066994321123 0.218912325435361 no 708 0.248040179504969 1224 16459611 SGTC_1647 st011722 22.4 µM 0.680536808840245 0.218955238889368 no 709 0.24808231160474 1224 2854783 SGTC_1885 st057546 99.9 µM 0.680450133008923 0.218983179874688 no 710 0.248109743348314 1257 702008 SGTC_863 0466-0191 129 µM 0.679672632012221 0.219233908259514 no 711 0.248355884371645 1226 765160 YPR165W RHO1 SGTC_1500 4488-1866 171 µM 0.679620947168225 0.219250581426237 no 712 0.248372251356269 1277 2900003 SGTC_1649 st011737 51.3 µM 0.679428124390887 0.219312791127845 no 713 0.24843331741349 1195 1761035 SGTC_990 3985-0011 41.3 µM 0.678935288302602 0.219471839107807 no 714 0.248589432615146 1196 5399565 YGL099W LSG1 SGTC_1556 plumbagin 1.48 µM 0.67885189766914 0.219498757472165 no 715 0.24861585335245 1156 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2115 tiliquinol 12.7705 µM 0.677765268330029 0.219849693030964 no 716 0.248960267898624 1204 71208 A bioactive hydroxyquinoline. SGTC_2894 9048625 32.47 µM 0.677718122510361 0.219864926432806 no 717 0.248975216831366 1285 4092861 SGTC_994 3910-0338 138 µM 0.676692041521563 0.220196616022154 no 718 0.249300683495008 1285 3479481 SGTC_816 0325-0417 81.3 µM 0.676086886055526 0.220392372232717 no 719 0.249492741128002 1218 68101 SGTC_299 1273-0059 1.44 µM 0.675456207151135 0.220596490898567 no 720 0.249692982746799 1191 2848077 SGTC_2453 5731132 22.18 µM 0.675374793777285 0.220622848155235 no 721 0.24971883784942 1274 1362040 SGTC_1726 st035556 14.5795 µM 0.67512862927485 0.22070255390939 no 722 0.249797022946111 1271 5919439 SGTC_2586 curcumin 80 µM 0.674880153837892 0.220783024646 no 723 0.24987595520455 1240 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2747 doxorubicin 7.63 µM 0.674490759476595 0.220909166882655 no 724 0.249999679274407 1126 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2363 9053361 176 µM 0.673950654708746 0.221084199238262 no 725 0.250171343057528 1275 6469797 YMR079W SEC14 SGTC_29 0299-0004 12.984 µM 0.673499800677066 0.221230368759825 no 726 0.25031468776241 1132 16871 A napthoquinone isolated from Swertia calycina. SGTC_2933 9026794 32.47 µM 0.670681319686359 0.222145388873336 no 727 0.251211782782831 1236 17586027 SGTC_3101 9120531 49.47 µM 0.669769948997898 0.22244172695604 no 728 0.251502226544073 1293 24824904 SGTC_3152 9099253 49.47 µM 0.669280495272163 0.22260096901404 no 729 0.25165828323951 1247 25236131 SGTC_367 0335-0881 7.1 µM 0.668619565483118 0.222816103307117 no 730 0.251869094240061 1210 23828853 SGTC_1275 0867-0008 21.1 µM 0.667197006115226 0.223279551614011 no 731 0.252323151621549 1221 3422836 SGTC_983 1491-0821 12.2 µM 0.665854688405203 0.223717361047314 no 732 0.25275199257218 1210 46495113 SGTC_1408 3909-7976 48.8 µM 0.665638159163715 0.223788029764311 no 733 0.252821204825514 1276 24152374 SGTC_932 2857-0803 154 µM 0.664619916647987 0.224120523986343 no 734 0.253146813579848 1332 674898 SGTC_3027 9089541 49.47 µM 0.663446576021429 0.224504011240713 no 735 0.253522292208169 1244 9943819 SGTC_506 n9-isopropylolomoucine 153 µM 0.663113790413522 0.224612844528841 no 736 0.253628839572952 1254 6610355 SGTC_2208 7283366 200 µM 0.662902053426273 0.224682105985949 no 737 0.253696643261156 1248 898663 SGTC_280 3448-3607 3.04 µM 0.662548462204473 0.224797796497031 no 738 0.253809893580642 1232 626179 SGTC_2497 7-hydroxyflavone 100 µM 0.662354589002747 0.224861243655503 no 739 0.253871999717116 1255 5281894 SGTC_3132 9126706 49.47 µM 0.661509700622643 0.225137861254778 no 740 0.254142747823528 1262 850858 SGTC_319 1348-1596 45.5 µM 0.65473164677483 0.227363969894323 no 741 0.25632027299336 1319 5380505 SGTC_2052 5265182 7.135 µM 0.653229730087331 0.227858915759504 no 742 0.256804093220243 1271 1239884 SGTC_3320 9137005 35.139 µM 0.653163996658507 0.227880591577879 no 743 0.256825279123117 1242 4908713 SGTC_2469 5655019 90.81 µM 0.649741182553264 0.229010877827262 no 744 0.257929708718124 1330 2788239 SGTC_2834 9001755 58.44 µM 0.649503793454961 0.229089385239205 no 745 0.25800639764563 1230 2989575 SGTC_2977 9011197 71.43 µM 0.649154026522407 0.229205084847328 no 746 0.258119411958455 1302 2704722 SGTC_1311 1190-0148 100 µM 0.648814198580753 0.229317528108249 no 747 0.258229239431801 1318 1961333 SGTC_1262 0737-0114 49.6 µM 0.64848095870737 0.229427821514813 no 748 0.258336961255158 1302 765919 SGTC_1427 4048-4900 550 nM 0.647050665932581 0.229901547329176 no 749 0.258799576444246 1268 24132586 SGTC_2272 7805186 180 µM 0.644620192118902 0.230707796444926 no 750 0.259586673154068 1261 2956062 YPR165W RHO1 SGTC_2567 aureobasidin a 60 nM 0.642818523296376 0.231306473155908 no 751 0.260170931185471 1349 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3108 9121785 49.47 µM 0.642146305748393 0.23153006616549 no 752 0.260389096183785 1255 17140271 SGTC_2909 7941780 10.49 µM 0.641908381396069 0.231609233426961 no 753 0.260466335969728 1279 1243215 SGTC_2150 5556613 200 µM 0.641529560530054 0.231735313908385 no 754 0.260589340758625 1295 743190 SGTC_1954 st077032 68.9 µM 0.639858651409915 0.232291887792649 no 755 0.261132248863748 1207 698907 SGTC_694 1315-0438 43.2 µM 0.639433477988847 0.232433630157304 no 756 0.261270487999545 1256 6793154 SGTC_1810 st050138 53 µM 0.639144304043243 0.232530061118244 no 757 0.261364530302888 1276 3444541 SGTC_937 3122-0005 46.7 µM 0.638899874843734 0.232611588374697 no 758 0.261444034717064 1270 759535 SGTC_563 tetrahydrosecaminediol 614 µM 0.638789466118761 0.232648419464284 no 759 0.261479950950253 1319 334274 A psychoactive constituent of the cannabis plant. SGTC_751 0833-0568 350 µM 0.637629193457913 0.233035669142153 no 760 0.261857543675443 1313 6954252 SGTC_3194 9111903 49.47 µM 0.636444500401186 0.233431438361616 no 761 0.262243371977057 1314 17087251 SGTC_291 SEC14.278 35.5 µM 0.636277917600778 0.233487118396126 no 762 0.262297647652336 1276 1068044 SGTC_602 3130-1533 38.1 µM 0.633089361378834 0.234554307036074 no 763 0.263337644593587 1328 720941 SGTC_1507 4075-3230 155 µM 0.632614898347073 0.234713336956642 no 764 0.263492577824711 1232 659771 SGTC_1081 sertraline 6 µM 0.631388762243421 0.235124587679679 no 765 0.263893181019079 1293 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3238 9133470 49.47 µM 0.631379999065105 0.235127528314739 no 766 0.263896045241793 1359 3534688 SGTC_847 0342-0274 5.54 µM 0.630832954475441 0.235311138733783 no 767 0.264074876752686 1295 18097 SGTC_1483 3453-0561 55.9 µM 0.630361963461078 0.235469285869516 no 768 0.264228895433593 1307 4546991 SGTC_3033 9090887 49.47 µM 0.628116372029774 0.236224105800579 no 769 0.264963854337085 1273 19325384 SGTC_2998 9066762 71.4286 µM 0.627264159073939 0.236510912105594 no 770 0.265243046515852 1352 4945196 SGTC_2913 7966556 36.57 µM 0.627021967517677 0.23659245493354 no 771 0.265322417766664 1277 2976516 SGTC_640 3381-0960 37.1 µM 0.626583544526393 0.236740105736154 no 772 0.265466128831882 1345 1745025 SGTC_3034 9090421 49.47 µM 0.626020401471414 0.23692983372574 no 773 0.265650779926258 1253 17173761 SGTC_1935 st074532 41.6 µM 0.625136178245782 0.23722790511206 no 774 0.265940842565499 1360 2829742 SGTC_2687 chenodiol 100 µM 0.622306065109742 0.23818331864252 no 775 0.266870316915517 1328 5702181 A cholesterol synthesis inhibitor. SGTC_2944 9067346 25.62 µM 0.621530098002803 0.238445643973308 no 776 0.267125448781411 1292 6473075 SGTC_185 k048-0037 25.491 µM 0.620289177860554 0.238865481022765 no 777 0.267533709289859 1308 6827589 SGTC_2678 equilin 100 µM 0.61957558696543 0.239107091209253 no 778 0.267768621811489 1361 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2988 9073640 71.4286 µM 0.618421431601635 0.239498151880179 no 779 0.268148787022475 1346 9102229 SGTC_2367 9070478 135.38 µM 0.618420960873859 0.239498311447353 no 780 0.268148942130069 1319 572802 SGTC_873 0591-4978 488 µM 0.618109053113477 0.239604054616332 no 781 0.268251727513579 1452 3305145 SGTC_1604 st002052 72.4 µM 0.61662420021657 0.240107799659609 no 782 0.268741314240651 1347 6254834 YHR062C RPP1 SGTC_220 paclitaxel 373.376 µM 0.616590797352761 0.240119138412747 no 783 0.268752333016379 1303 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2916 7875993 68.79 µM 0.615920718229206 0.240346661446922 no 784 0.268973423418214 1337 1299250 SGTC_611 3453-1652 23.7 µM 0.615812161097683 0.240383532694787 no 785 0.269009250078714 1329 1560575 SGTC_221 trifluoperazine 10.304 µM 0.61569863246654 0.240422095799973 no 786 0.269046720024803 1308 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.615621495349403 0.240448299454297 no 787 0.269072180503369 1292 61125 An anti-inflammatory. SGTC_2060 5238662 140 µM 0.61547041284993 0.24049962702977 no 788 0.269122051474725 1299 790130 SGTC_1022 4477-0945 21.3 µM 0.615394787820525 0.240525321520729 no 789 0.269147016357018 1309 4648966 SGTC_1257 0669-0121 16 µM 0.613882114667061 0.24103958381166 no 790 0.269646614898852 1350 4307855 SGTC_1646 st011709 75.6 µM 0.612334658113429 0.241566289452929 no 791 0.270158181808129 1302 5757843 SGTC_1755 st041960 45.185 µM 0.612167890692026 0.24162308912986 no 792 0.270213341684414 1339 2257073 SGTC_3183 9108214 49.47 µM 0.611173016757947 0.241962086000549 no 793 0.270542522469543 1250 4974831 SGTC_1877 wortmannin 25 µM 0.610505162375773 0.242189797710843 no 794 0.270763612372053 1311 312145 A covalent inhibitor of PI 3-kinase. SGTC_283 0987-0079 11.7 µM 0.61011837006038 0.242321731570259 no 795 0.270891699296816 1339 411556 SGTC_1854 st056233 32.9 µM 0.609518808409616 0.242526317453525 no 796 0.271090304888684 1292 5393174 SGTC_3162 9099653 49.47 µM 0.609198900973398 0.242635516375615 no 797 0.27119630435394 1311 25237511 SGTC_2496 diffractaic acid 79.83 µM 0.60776211646136 0.243126284228521 no 798 0.271672629197483 1415 94870 An apoptosis inducer which activates caspases. SGTC_2786 7743617 45.45 µM 0.607739851730836 0.243133893496699 no 799 0.271680013708295 1254 583674 SGTC_1247 0448-0043 5.84 µM 0.607423932956994 0.243241876820556 no 800 0.271784804795442 1362 3089013 YGL099W LSG1 SGTC_2746 daunorubicin 9.88 µM 0.607312273123181 0.243280049159917 no 801 0.271821847466194 1261 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1263 0774-1208 64.8 µM 0.60516474724352 0.244014837879664 no 802 0.27253476837327 1381 906585 SGTC_763 3453-1109 128 µM 0.605127194884495 0.244027697283507 no 803 0.272547243001543 1330 1560353 SGTC_1687 st020778 55.3625 µM 0.604294289597725 0.244313010740479 no 804 0.272824001102224 1342 4259299 SGTC_2122 5258151 111.688 µM 0.60393245480461 0.244437014008062 no 805 0.272944275131315 1314 2173356 SGTC_720 r052-1644 49.9 µM 0.603830832864944 0.244471846643093 no 806 0.272978059032748 1307 1422863 YOR257W CDC31 SGTC_2565 isoliquiritigenin 100 µM 0.602330354464524 0.244986472057878 no 807 0.273477129636252 1280 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1261 0712-0010 12.7 µM 0.602029980663643 0.245089562500054 no 808 0.273577090494243 1370 2840123 SGTC_2457 5731572 11.68 µM 0.601008958292135 0.24544015908327 no 809 0.273917009826805 1381 2865357 SGTC_1007 4101-0031 70 µM 0.600655545610254 0.245561575964896 no 810 0.274034716794415 1331 1146276 SGTC_365 0121-0052 13.6 µM 0.600637677768631 0.245567715417446 no 811 0.274040668488091 1352 3101739 SGTC_1568 digitonin 820 nM 0.598493324792265 0.246305120920822 no 812 0.274755405809146 1404 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3328 9140624 29.0385 µM 0.598393464210897 0.246339490132569 no 813 0.274788712864439 1371 4904392 SGTC_742 0kpi-0133 140 µM 0.596961766912994 0.24683252270039 no 814 0.275266453550189 1397 2728852 SGTC_2460 5552655 174.22 µM 0.59683523591354 0.246876121479957 no 815 0.275308695123641 1313 5401989 SGTC_1603 st002045 67.8 µM 0.594517325804212 0.24767553249449 no 816 0.276083078795087 1331 5887985 SGTC_2856 9022925 19.48 µM 0.593056108383801 0.248180193132636 no 817 0.276571801514821 1367 4944862 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.593011175978344 0.248195720123132 no 818 0.276586836446554 1411 1273210 SGTC_11 0438-0307 1.3 µM 0.592766686039295 0.248280215952156 no 819 0.276668652786778 1388 4011476 SGTC_861 0443-0273 110 µM 0.592217399470609 0.248470105550505 no 820 0.276852509796907 1373 6149169 SGTC_2524 avocatin b 10.57 µM 0.592181942689199 0.248482365697889 no 821 0.276864379934157 1309 6710748 SGTC_2709 st078560 56 µM 0.590896762663864 0.248926969194258 no 822 0.277294797621972 1405 17250903 SGTC_1690 st023502 41.2 µM 0.59047226161321 0.249073916800599 no 823 0.27743703848601 1376 24207482 SGTC_226 1,3-diallylurea 8.28947 mM 0.589145192088808 0.249533599933244 no 824 0.277881939882607 1318 74537 YKL182W FAS1 SGTC_2288 7946289 167.31 µM 0.589034562486974 0.249571941225539 no 825 0.277919044288718 1435 1246052 SGTC_3323 9138564 53.9225 µM 0.588902725745593 0.249617636438103 no 826 0.277963264580942 1390 43912313 YNL103W MET4 SGTC_3265 9137266 49.47 µM 0.587808411810125 0.249997102096335 no 827 0.278330448623037 1325 17224265 SGTC_538 2922-0838 53.3 µM 0.587793553561366 0.250002256466576 no 828 0.278335435758314 1427 777039 SGTC_1370 2001-0092 44.6 µM 0.587532616228567 0.250092785585879 no 829 0.278423025841732 1498 790957 SGTC_636 0kpi-0074 126 µM 0.585282915978031 0.250874013222703 no 830 0.279178750090018 1343 616434 SGTC_3176 9106582 49.47 µM 0.584687282534399 0.25108106809662 no 831 0.279379003401848 1292 17018027 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.584079361467961 0.251292487596006 no 832 0.279583459765439 1398 5024745 SGTC_1849 st056239 19.2 µM 0.583324256650635 0.251555224871177 no 833 0.279837518154982 1268 5393181 SGTC_2371 9071574 200 µM 0.58319594274725 0.251599885870305 no 834 0.279880701069785 1329 45596039 SGTC_1739 st037196 92.5 µM 0.581897459157986 0.252052072256639 no 835 0.280317876030958 1404 612214 SGTC_2976 9009005 19.48 µM 0.580716386646317 0.252463743248792 no 836 0.280715807885887 1429 2993148 SGTC_255 tunicamycin 200.472 nM 0.579718174751945 0.252811952994491 no 837 0.281052342485432 1359 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1222 0366-0074 1.18 µM 0.579088267473832 0.253031815800107 no 838 0.281264808074287 1409 286520 SGTC_2176 5809774 33.9695 µM 0.578474132915416 0.253246270110747 no 839 0.281472028207182 1365 2870539 SGTC_326 k292-0812 17.5 µM 0.577729594942351 0.253506389088881 no 840 0.281723347552986 1374 3579357 SGTC_1706 st031321 9.9705 µM 0.577645615023499 0.253535737932237 no 841 0.281751701824545 1409 6103185 SGTC_2499 avocadenofuran 51.48 µM 0.575772813890241 0.254190697752687 no 842 0.282384375729611 1307 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_984 1492-0255 2.91 µM 0.575571944126317 0.254260998983962 no 843 0.282452274564763 1383 1585198 SGTC_1624 st003710 6.25 µM 0.574371031457169 0.254681511932823 no 844 0.282858375779131 1429 24207033 SGTC_1553 gossypol 38.6 µM 0.572294036804853 0.255409653478982 no 845 0.283561394483492 1316 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.572055586608335 0.255493317621907 no 846 0.283642158370812 1419 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2692 st077426 47.7 µM 0.571587329624073 0.255657654884181 no 847 0.283800790652107 1375 25238571 SGTC_969 1313-0238 134 µM 0.570858620374736 0.255913508995847 no 848 0.284047741279075 1404 5212874 SGTC_3190 9110366 49.47 µM 0.57065244416594 0.255985922920232 no 849 0.284117630519722 1346 17123768 SGTC_1040 k898-0338 155 µM 0.569798870977023 0.256285831566063 no 850 0.284407060697585 1461 20969351 SGTC_701 4424-0219 185 µM 0.5692750263062 0.256469978546525 no 851 0.284584756035975 1424 2911779 SGTC_1103 duloxetine 36.1 µM 0.568265209404611 0.256825153646809 no 852 0.284927449385444 1485 60835 A selective serotonin reuptake inhibitor. SGTC_2763 lisinopril 49.32 µM 0.565492575018995 0.2578016657155 no 853 0.2858693865793 1367 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2221 6807166 181.081 µM 0.565320292573655 0.257862406512339 no 854 0.285927964304152 1370 674925 SGTC_3349 9149703 23.001 µM 0.565307381174732 0.257866958921541 no 855 0.285932354536526 1356 4910494 SGTC_190 3970-0790 3.722 µM 0.565294188331482 0.257871610607819 no 856 0.285936840500847 1430 2832352 SGTC_19 0279-0214 38.434 µM 0.565246161587807 0.257888544804037 no 857 0.285953171323737 1427 3566274 YBR002C RER2 SGTC_1456 k015-0012 13 µM 0.565206456525511 0.25790254521691 no 858 0.285966672809959 1464 2989616 SGTC_1797 st048695 56.8 µM 0.565149110399109 0.257922766746297 no 859 0.285986173577023 1388 592262 YIL048W NEO1 SGTC_1205 4161-2785 76 µM 0.56412105416981 0.258285421921723 no 860 0.28633587516709 1347 3498106 SGTC_1650 st011916 45.8 µM 0.563842674234699 0.258383668151628 no 861 0.286430603254211 1403 242528 SGTC_85 0868-0259 160.055 µM 0.562677187955904 0.258795203302626 no 862 0.28682736034791 1415 83173 SGTC_620 0109-0052 432 µM 0.561801510538048 0.259104629481774 no 863 0.287125631410981 1409 493037 SGTC_3039 9090270 49.47 µM 0.560911373315429 0.259419361058306 no 864 0.287428978163912 1404 17173750 SGTC_1824 st053723 68.6 µM 0.559567491641554 0.259894899857167 no 865 0.287887241863285 1353 675225 SGTC_1983 st071813 46.9 µM 0.559409574786588 0.259950808982271 no 866 0.287941114162511 1390 11838595 SGTC_958 1222-0007 33 µM 0.557864636269705 0.260498108397137 no 867 0.288468410702195 1484 7312461 SGTC_1365 1672-3266 55.4 µM 0.557838290442695 0.260507446633473 no 868 0.288477406632025 1421 6415873 SGTC_1972 st070201 17.4 µM 0.557606555713628 0.260589592063702 no 869 0.288556539445409 1422 2829099 SGTC_1512 0259-0544 12.2 µM 0.556660768823797 0.260924993238813 no 870 0.288879612912912 1394 18476 SGTC_2531 methyl deoxycholate 70.07 µM 0.556148693108434 0.261106681499183 no 871 0.28905460501511 1374 16667744 Haematoxylin. SGTC_1560 lithocholic acid 53.1 µM 0.556078922300842 0.261131441731815 no 872 0.289078451715898 1376 9903 A bile acid which acts as a detergent. SGTC_2407 paclitaxel 400 µM 0.555006524205128 0.261512165648561 no 873 0.289445098962764 1545 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1229 0139-0193 12.2 µM 0.553301493033947 0.262118073835081 no 874 0.290028489432747 1459 3090752 SGTC_1548 st061468 90.8 µM 0.550564193736312 0.263092316274832 no 875 0.290966230040703 1407 390799 SGTC_2930 9013230 14.89 µM 0.550037781932458 0.263279885384467 no 876 0.291146729841406 1468 2995857 SGTC_792 4534-1957 155 µM 0.549850535347115 0.263346620859289 no 877 0.291210946879308 1424 1717904 SGTC_3010 9080089 71.4286 µM 0.547174227707562 0.264301411284459 no 878 0.292129520191621 1471 17027233 SGTC_554 4483-2211 187 µM 0.544461382577127 0.265271032282387 no 879 0.293062007872037 1422 747107 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.542717344200002 0.265895336115051 no 880 0.293662215288134 1477 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1602 st001878 87.6 µM 0.542631870947706 0.265925951632395 no 881 0.293691645362528 1452 595405 YLR310C CDC25 SGTC_3013 9080133 71.4286 µM 0.542374390875529 0.266018188769855 no 882 0.293780308921369 1484 17050193 SGTC_1808 st050063 61.5 µM 0.541410642499279 0.266363576329203 no 883 0.294112286665091 1462 4011993 SGTC_686 1319-0111 510 µM 0.540748811614838 0.266600894228537 no 884 0.294340364711708 1503 4562600 SGTC_1203 3992-3522 103 µM 0.540318390389696 0.266755291102756 no 885 0.294488738917021 1656 5322312 SGTC_217 ketoconazole 989 nM 0.53982481856429 0.266932396404785 no 886 0.294658924785159 1368 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_897 1000-0139 31.4 µM 0.539338620654202 0.26710691382323 no 887 0.294826612432551 1461 6151020 SGTC_627 1391-0720 175 µM 0.538027630336821 0.267577771734545 no 888 0.295278986653243 1403 997839 SGTC_1640 st009078 66.4 µM 0.537771758292451 0.267669720033042 no 889 0.295367315868556 1482 690618 SGTC_799 1310-0557 151 µM 0.536839975240912 0.26800469327638 no 890 0.29568907803339 1442 5354492 SGTC_2284 7945075 39.21 µM 0.535418355376716 0.268516167734338 no 891 0.296180300156986 1508 1245402 SGTC_2216 7189485 200 µM 0.533424207114773 0.269234454059233 no 892 0.296869982140088 1455 731273 SGTC_2642 cholecalciferol 100 µM 0.533361683087666 0.269256990602546 no 893 0.296891618135162 1460 9821465 A vitamin D precursor, similar to steriods. SGTC_1330 1469-0054 61.8 µM 0.532791711816244 0.269462478155691 no 894 0.297088885902909 1522 7102664 SGTC_2825 7998094 58.44 µM 0.532354722047707 0.269620076082753 no 895 0.297240169186161 1450 2987815 SGTC_2860 9025725 38.96 µM 0.531757648770739 0.26983548186183 no 896 0.297446929333261 1385 40546248 SGTC_409 arachidonic acid 100 µM 0.531526244709739 0.269918988531758 no 897 0.297527079763722 1447 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2766 oltipraz 83.91 µM 0.530822027807912 0.270173198495357 no 898 0.297771056988128 1506 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3144 9087057 49.47 µM 0.530121844647571 0.270426071008999 no 899 0.298013727152489 1437 17249618 SGTC_2083 5306046 65.942 µM 0.529931464909921 0.270494847469481 no 900 0.298079724729877 1419 539837 SGTC_810 3825-7150 143 µM 0.528891006469344 0.270870877143111 no 901 0.298440530582519 1546 22330411 YGL099W LSG1 SGTC_610 4215-0184 155 µM 0.527613870059078 0.271332800421806 no 902 0.298883682114295 1473 5605015 SGTC_84 0443-0269 128.823 µM 0.527501751654687 0.271373370896165 no 903 0.29892260017154 1409 6150058 SGTC_1783 st039459 87.517 µM 0.52739554122324 0.271411806335679 no 904 0.298959469601734 1578 729761 SGTC_2801 7907800 81.82 µM 0.527339448587848 0.271432106237499 no 905 0.298978942190199 1446 6620925 SGTC_1453 4237-0541 195 µM 0.527031107219114 0.271543708358395 no 906 0.299085993346296 1448 739892 SGTC_2980 9014342 25.29 µM 0.525565014090487 0.272074663531266 no 907 0.299595235162056 1440 2996599 SGTC_3014 9081533 49.47 µM 0.524434578275981 0.272484410369812 no 908 0.299988155759424 1536 21367265 SGTC_3300 9124615 50.48 µM 0.523540368487071 0.272808749746407 no 909 0.300299133214349 1519 24824903 SGTC_2421 5690543 90.72 µM 0.522813399935614 0.273072570010881 no 910 0.300552056858992 1480 3397993 SGTC_1321 1326-2144 215 µM 0.522376473795458 0.273231193355118 no 911 0.300704116511131 1494 3513030 SGTC_840 0245-0196 390 µM 0.521849199971491 0.273422677631747 no 912 0.300887665307943 1523 3827528 SGTC_548 1436-0017 110 µM 0.520385567609037 0.273954556955944 no 913 0.301397433594492 1564 9677137 SGTC_252 miconazole 1.30953 nM 0.519618057023742 0.274233672106134 no 914 0.301664905030074 1429 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1631 benzylvanillin 81.9 µM 0.519150037113407 0.27440394250034 no 915 0.301828058681637 1486 75506 SGTC_2328 6201408 200 µM 0.519051466916423 0.274439809989753 no 916 0.301862425709941 1434 2890418 SGTC_2711 st079103 59.1 µM 0.517317567054409 0.2750711154133 no 917 0.302467246490892 1526 54693780 SGTC_1145 3546-0597 10.2 µM 0.516865277554368 0.275235909606696 no 918 0.302625103900175 1450 875334 SGTC_2182 6325192 200 µM 0.515988155782161 0.275555632253962 no 919 0.302931340804648 1424 736248 SGTC_12 0849-0099 9.267 µM 0.51548687191753 0.275738438929408 no 920 0.303106420523101 1491 6071388 SGTC_2699 st077704 54.6 µM 0.514748615064997 0.276007772681149 no 921 0.303364348428128 1486 645852 SGTC_1412 3909-8563 178 µM 0.514454589192996 0.276115076310627 no 922 0.303467100788301 1544 23767530 SGTC_2164 5685496 200 µM 0.514340684524032 0.276156650891337 no 923 0.303506910896838 1471 759046 SGTC_773 4358-1457 44.6 µM 0.513425885430625 0.276490658941833 no 924 0.303826721161484 1582 1186886 SGTC_3063 1327-0034 4 µM 0.513222521556299 0.276564937307434 no 925 0.303897836813639 1388 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_786 4544-0069 423 µM 0.511801571860649 0.277084209947157 no 926 0.304394945075239 1519 748821 YLR208W SEC13 SGTC_3178 9107506 49.47 µM 0.510338097164762 0.277619521237035 no 927 0.304907308418846 1481 8897194 SGTC_1466 k213-0079 57.5 µM 0.509919382051724 0.277772772191107 no 928 0.305053971290589 1452 3657981 SGTC_2061 5245884 80.95 µM 0.509623094249287 0.277881239343959 no 929 0.30515777060792 1446 573863 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.508767792290691 0.278194470325791 no 930 0.305457498794444 1534 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_570 0987-0065 62.6 µM 0.508298392347974 0.27836644837934 no 931 0.30562204866165 1411 3104428 SGTC_1245 0418-0076 17.2 µM 0.507214444745679 0.278763781359924 no 932 0.306002180442244 1505 6790114 SGTC_3218 9131285 49.47 µM 0.506983194844516 0.278848584284095 no 933 0.306083305006814 1613 17156417 SGTC_322 k048-0136 19.3 µM 0.505471007302538 0.279403436142561 no 934 0.306614028438753 1466 6823282 SGTC_83 0170-0301 39.027 µM 0.505185392838557 0.279508293982051 no 935 0.306714314432613 1474 3089716 SGTC_2246 7293507 91.5585 µM 0.505114298872185 0.27953439772992 no 936 0.306739279455365 1601 887656 SGTC_2078 5212016 200 µM 0.503048271978451 0.280293502511822 no 937 0.307465166945005 1483 1899708 SGTC_3262 9137218 49.47 µM 0.50182404754392 0.280743780720029 no 938 0.307895647941749 1404 17650664 SGTC_1188 1403-0014 4.57 µM 0.501823289433452 0.280744059666649 no 939 0.307895914602453 1480 9614867 SGTC_1033 k072-0102 21.3 µM 0.50166136441627 0.280803643021327 no 940 0.307952873058217 1587 5965931 SGTC_515 4092-1064 102 µM 0.501524894214276 0.280853864545949 no 941 0.308000881166678 1595 717353 SGTC_2896 9052656 71.43 µM 0.50121772270247 0.280966920650123 no 942 0.308108951379147 1440 6469436 SGTC_183 3914-0051 30.55 µM 0.499011182841194 0.281779695154775 no 943 0.308885752978338 1600 1596232 SGTC_2425 5628681 7.85 µM 0.497620807563943 0.282292418417707 no 944 0.309375667516526 1547 5714958 SGTC_404 fumagillin 50 µM 0.497340726002249 0.282395757298889 no 945 0.309474398494803 1499 12015870 A methionine aminopeptidase binder. SGTC_2738 aclarubicin 5.55 µM 0.496638764031351 0.282654833080072 no 946 0.309721906092192 1502 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3177 9107506 49.47 µM 0.495875257750043 0.282936752880033 no 947 0.309991211825612 1516 8897194 SGTC_2871 9038510 12.99 µM 0.494501124463608 0.283444482679399 no 948 0.310476156208218 1612 4945164 SGTC_652 0437-0092 114 µM 0.494204676816723 0.283554074644781 no 949 0.310580818584066 1450 3091274 SGTC_2013 4024628 200 µM 0.492558690800491 0.2841629384634 no 950 0.311162221221244 1519 5230760 SGTC_2402 5553605 200 µM 0.492291391202101 0.284261873768429 no 951 0.311256682535214 1576 6758546 SGTC_1012 4112-3522 18 µM 0.491721023412425 0.284473038406329 no 952 0.311458287023708 1563 3112398 SGTC_68 0986-0284 82.829 µM 0.49167353826838 0.284490621990767 no 953 0.311475073864006 1430 423278 YIL048W NEO1 SGTC_2057 5236571 38.335 µM 0.490920449606251 0.284769557499354 no 954 0.311741356436302 1578 54684039 YBR257W POP4 SGTC_3334 9142812 21.919 µM 0.489386152244872 0.285338247341576 no 955 0.312284168999718 1537 45283678 SGTC_458 nppb 133 µM 0.488657787068623 0.28560840631659 no 956 0.312541997012299 1607 4549 A chloride channel blocker. SGTC_973 1325-0077 65.9 µM 0.488502941532305 0.285665855983158 no 957 0.31259682134704 1613 2835149 SGTC_1200 1643-0193 18.4 µM 0.487032730341688 0.286211596812034 no 958 0.313117568182801 1494 5403974 SGTC_2175 5807670 165.306 µM 0.486889339727481 0.28626484974547 no 959 0.313168376924249 1471 241186 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.486302131624685 0.28648297831955 no 960 0.313376484060887 1525 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3209 9113616 49.47 µM 0.486201511841919 0.286520363185865 no 961 0.313412149778466 1655 16649353 SGTC_487 nimodipine 119 µM 0.486000341897447 0.286595113989892 no 962 0.313483461767018 1526 4497 L-type voltage-gated calcium channels inhibitor SGTC_334 1502-1024 68.5 µM 0.484954048924134 0.286984045015761 no 963 0.31385447067495 1512 3296216 SGTC_848 0368-0089 85.6 µM 0.484034300677455 0.287326142823084 no 964 0.314180763144423 1510 762535 SGTC_1389 3405-0187 19 µM 0.483974484061408 0.28734839812788 no 965 0.314201988889248 1459 799890 SGTC_844 0330-0132 15.3 µM 0.48391761371956 0.287369558001363 no 966 0.314222169727441 1553 2828079 SGTC_3111 9122088 49.47 µM 0.481264691683005 0.288357454789248 no 967 0.315164194053717 1521 16876704 SGTC_2899 9053889 58.44 µM 0.480597123144842 0.288606296303303 no 968 0.31540143024856 1516 6470052 SGTC_2740 felodipine 17.08 µM 0.479225377718928 0.289117942639723 no 969 0.315889151113315 1591 3333 L-type calcium channel blocker SGTC_1085 doxorubicin 7.67 µM 0.47735102303742 0.289817745641845 no 970 0.316556091896999 1608 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2441 5730946 39.09 µM 0.476555299797458 0.290115074385406 no 971 0.3168394101187 1587 1774275 SGTC_791 1348-1292 225 µM 0.475644498139946 0.290455578509285 no 972 0.317163834032712 1564 5437054 SGTC_2568 diosmetin 100 µM 0.474008697033384 0.291067593661677 no 973 0.317746852678497 1522 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2394 5221648 200 µM 0.47370796885173 0.291180172980087 no 974 0.317854084967835 1669 788586 SGTC_2999 9069765 71.4286 µM 0.473329893525175 0.291321736485985 no 975 0.317988919026252 1577 2097066 SGTC_3225 9130819 49.47 µM 0.473162954012196 0.291384254204652 no 976 0.318048462811364 1551 4547121 SGTC_1790 st045711 43.5 µM 0.473139413676069 0.291393070404906 no 977 0.318056859528616 1645 585119 SGTC_2612 dictamnine 15.46 µM 0.47262813296359 0.291584583210243 no 978 0.318239253806457 1523 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3071 9117417 49.47 µM 0.472493413761273 0.291635055378788 no 979 0.318287320872906 1580 45595590 YGL055W OLE1 SGTC_1167 k781-0610 148 µM 0.472408888259655 0.291666724698345 no 980 0.318317480666658 1530 4525169 SGTC_1555 citronellol 128 µM 0.471628364361976 0.291959240689006 no 981 0.318596038587818 1612 8842 A terpine precursor. SGTC_991 3996-0057 64.7 µM 0.468962599436234 0.292959314729772 no 982 0.319548184829306 1543 715343 SGTC_2160 5660466 132.927 µM 0.467853910478894 0.293375712036733 no 983 0.319944532489896 1580 2859134 SGTC_2877 9040724 71.43 µM 0.466048325362943 0.294054433360949 no 984 0.320590455081594 1625 6463895 SGTC_3061 glucosamine 200 µM 0.466023972531797 0.294063592574315 no 985 0.320599170683415 1579 91431 and experimental redox chemotherapeutic SGTC_2438 5259590 200 µM 0.465434735520234 0.294285247546981 no 986 0.320810082062122 1640 1201127 SGTC_1510 1123-0200 71.5 µM 0.464168593247701 0.294761796775207 no 987 0.321263480411162 1646 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2926 9010726 65.15 µM 0.463981841036729 0.294832116466786 no 988 0.321330377886276 1486 2994293 SGTC_2989 9073649 71.4286 µM 0.462491427167723 0.295393593935694 no 989 0.321864474330235 1580 21367202 SGTC_2227 7312221 64.1025 µM 0.461781903448101 0.295661062602226 no 990 0.322118864764371 1552 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_58 0957-0393 9 µM 0.461494136632801 0.295769573578428 no 991 0.322222063553155 1498 6997992 SGTC_147 4466-0538 29.23 µM 0.460276295136581 0.296228999117528 no 992 0.322658956910749 1572 6742687 YHR072W ERG7 SGTC_697 0508-1955 564 µM 0.459575840909405 0.296493390693708 no 993 0.322910351676923 1635 6243113 SGTC_1345 1488-0192 31.4 µM 0.459300330195657 0.296597413852978 no 994 0.323009255342685 1614 658348 SGTC_2736 butenafine 14.65 µM 0.458275696644906 0.296984426079955 no 995 0.323377191165272 1603 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3270 9137563 49.47 µM 0.457952433611754 0.297106573012952 no 996 0.323493307613427 1590 17015724 SGTC_1653 st012112 65 µM 0.457159824752048 0.297406162330103 no 997 0.323778086345245 1592 720429 SGTC_2155 5570423 76 µM 0.455857684537829 0.297898642984365 no 998 0.324246160061893 1541 797402 SGTC_2270 7924575 90.91 µM 0.455611862438182 0.297991656728358 no 999 0.324334555686681 1670 1262135 SGTC_2622 2-methoxyxanthone 59.94 µM 0.453262145398891 0.298881405791666 no 1000 0.325179993808261 1693 71034 A hepatoprotective. SGTC_372 0155-0182 15.9 µM 0.452961721870843 0.298995251800786 no 1001 0.32528815249721 1605 771486 SGTC_1552 6-methylflavone 10.6 µM 0.452927655576201 0.299008162524399 no 1002 0.325300417997781 1583 689013 SGTC_1100 amiodarone 5.07 µM 0.452782953488718 0.299063005729051 no 1003 0.325352519801187 1641 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1941 st076221 61.8 µM 0.452778510847029 0.299064689596697 no 1004 0.325354119484125 1600 2828568 SGTC_1529 apigenin 74 µM 0.452138994730262 0.29930712642115 no 1005 0.325584426625325 1634 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_864 0469-0573 172 µM 0.451032032526893 0.299726979893028 no 1006 0.325983231187156 1511 689425 SGTC_1779 st039427 55 µM 0.450846561521617 0.29979735223106 no 1007 0.32605007019801 1713 1124498 SGTC_489 paxilline 115 µM 0.449957144557247 0.300134923183746 no 1008 0.326370670979498 1504 105008 A toxic potassium channel blocker. SGTC_408 cantharidin 100 µM 0.449428261097679 0.30033573805182 no 1009 0.32656137408521 1567 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.448891821952227 0.300539483786803 no 1010 0.326754847906459 1576 17037758 SGTC_142 0335-0849 62.6745 µM 0.448515290135672 0.300682532155924 no 1011 0.326890676883314 1593 3889043 YPR107C YTH1 SGTC_2141 5621638 7.665 µM 0.44777809880455 0.300962687780977 no 1012 0.327156675520485 1640 2856238 SGTC_2914 7968218 45.32 µM 0.446408655431656 0.301483430961809 no 1013 0.327651040860949 1629 2977111 SGTC_3081 9117243 49.47 µM 0.445944627266703 0.301659973779296 no 1014 0.327818622379816 1674 45595589 SGTC_2546 rhodinyl acetate 100 µM 0.445718323692107 0.301746089447001 no 1015 0.327900363400185 1665 6708682 SGTC_1421 4029-0249 71.4 µM 0.445010132483785 0.302015649981936 no 1016 0.328156215854424 1666 2894095 SGTC_115 0527-0192 112.043 µM 0.444559754611004 0.302187134642895 no 1017 0.328318968507859 1560 4233931 SGTC_1955 wogonin 32.4 µM 0.443560842164695 0.302567633710613 no 1018 0.328680060875841 1651 5281703 A flavanone. SGTC_2466 5983409 37.09 µM 0.443368390609062 0.302640965738012 no 1019 0.328749647717689 1549 2879657 SGTC_1395 3486-0190 4.35 µM 0.442630602112765 0.302922167521296 no 1020 0.329016473078443 1676 6748079 SGTC_2886 9058944 51.95 µM 0.442532598268024 0.302959529647503 no 1021 0.329051923280049 1527 4949929 SGTC_3 0833-0587 95.581 µM 0.442085811909284 0.303129884686671 no 1022 0.32921355546319 1545 5382644 SGTC_1727 st034309 9.9045 µM 0.439883901157894 0.303970075708552 no 1023 0.330010598174915 1690 870305 SGTC_81 0411-0046 9.971 µM 0.439752547939835 0.304020229431956 no 1024 0.330058169560942 1503 12925265 SGTC_466 geldanamycin 89.2 µM 0.439629524684799 0.304067205926232 no 1025 0.330102726627645 1604 5288382 HSP90 inhibitor. SGTC_569 4130-2812 160 µM 0.438157305330091 0.304629624471434 no 1026 0.330636127893722 1590 743552 SGTC_2162 5663267 200 µM 0.437843880040375 0.304749419189036 no 1027 0.330749729793012 1665 6456493 SGTC_2983 9022671 12.99 µM 0.437678808233636 0.304812519933096 no 1028 0.330809566813449 1707 6405161 SGTC_1212 0520-0165 585 µM 0.437306380757808 0.304954906277131 no 1029 0.330944584245999 1769 5403258 SGTC_599 1935-0052 86.5 µM 0.436996734018465 0.30507331280132 no 1030 0.331056858302861 1551 9557311 SGTC_1764 st044502 93.5 µM 0.434972260608727 0.305847958271204 no 1031 0.331791281179322 1560 8407 SGTC_912 3474-0017 2.18 µM 0.433063326097842 0.306579190491253 no 1032 0.332484382461451 1675 3360550 SGTC_568 1193-0097 7.48 µM 0.43154444404061 0.307161560844606 no 1033 0.333036272002073 1545 3646150 SGTC_2190 6049624 200 µM 0.431499025548475 0.307178982722448 no 1034 0.333052780500439 1617 2265554 SGTC_2151 5563267 85.4165 µM 0.4311769680952 0.307302531795167 no 1035 0.333169849697223 1574 5310824 SGTC_1301 naphtanilide LB 4.81 µM 0.429670559467667 0.307880717029242 no 1036 0.333717651082773 1685 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1198 1612-1005 86.7 µM 0.427885501928855 0.308566470359412 no 1037 0.334367241467535 1670 6998509 SGTC_103 0844-0104 51.839 µM 0.427429960744775 0.308741579621011 no 1038 0.334533094495066 1666 5375804 SGTC_544 k015-0020 52.4 µM 0.423720413316259 0.310169139709755 no 1039 0.335884863028149 1606 3008304 SGTC_260 nsc-65238 3.989 µM 0.423691717017198 0.310180194218479 no 1040 0.335895328340617 1659 3246252 SGTC_1501 4491-0275 38.4 µM 0.423116347926921 0.310401876502385 no 1041 0.336105187723082 1669 5104718 SGTC_1968 st069590 43.6 µM 0.421651858586691 0.310966436035581 no 1042 0.336639574092461 1668 6384066 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.419984585409963 0.311609710515028 no 1043 0.33724835724083 1746 551469 SGTC_3261 9137475 49.47 µM 0.419693077804217 0.311722240377852 no 1044 0.337354841294039 1597 17027690 SGTC_3142 9086498 49.47 µM 0.419623012128775 0.311749290255215 no 1045 0.337380437344279 1657 25236367 SGTC_1314 1222-0010 41.1 µM 0.417287631975518 0.312651478255994 no 1046 0.338234016955825 1618 3526027 SGTC_2212 7123476 200 µM 0.416245626287063 0.313054381609906 no 1047 0.338615137951744 1655 1085715 SGTC_3153 9100258 49.47 µM 0.415595661687552 0.313305810953537 no 1048 0.33885295088272 1554 25236848 SGTC_1720 st037298 9.481 µM 0.415535817316674 0.313328965242932 no 1049 0.338874850330008 1581 597396 SGTC_40 0327-0103 19.753 µM 0.415162752948944 0.313473323566336 no 1050 0.33901138177032 1549 409036 SGTC_1807 st050092 58.9 µM 0.413934494768922 0.313948803405014 no 1051 0.339461040296904 1574 5008496 SGTC_1642 st009582 77.7 µM 0.413706453620315 0.314037116092634 no 1052 0.33954455008616 1716 6739311 SGTC_2537 larixol 68.93 µM 0.412565363553805 0.314479181906958 no 1053 0.339962541154854 1658 6708759 SGTC_358 0075-0058 9.45 µM 0.412385604405696 0.314548846066636 no 1054 0.340028406428153 1843 1069125 SGTC_2163 5671233 125 µM 0.410893813514742 0.315127231781327 no 1055 0.340575199471457 1711 701023 SGTC_350 k064-0020 19.8 µM 0.4090292080824 0.315850799935284 no 1056 0.341259113261259 1701 2790705 SGTC_695 3505-6186 243 µM 0.408361832922083 0.316109949499467 no 1057 0.341504024972701 1663 1819379 SGTC_135 0933-0004 26.348 µM 0.408277098812206 0.316142859211431 no 1058 0.341535125267806 1556 21230617 YGL099W LSG1 SGTC_895 0964-0006 13.7 µM 0.406640824133265 0.316778654080613 no 1059 0.342135904402624 1646 6738897 SGTC_2225 6654152 15.4 µM 0.40504961171864 0.317397458934159 no 1060 0.342720521873715 1676 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1050 3232-1156 69.3 µM 0.403015669728617 0.318189179932069 no 1061 0.343468348517324 1586 700529 SGTC_1178 0988-0033 191 µM 0.40284273685158 0.318256533223953 no 1062 0.343531959683232 1667 5392207 SGTC_1557 sumaresinolic acid 42.3 µM 0.401627941774146 0.318729836625908 no 1063 0.343978931463916 1568 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_898 1000-0849 28.3 µM 0.401139138641764 0.318920365584695 no 1064 0.344158843294612 1663 6751807 SGTC_2739 tacrine 100.86 µM 0.401039673710682 0.31895914155374 no 1065 0.344195457278511 1627 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1945 st075991 56.6 µM 0.4007801791052 0.319060313719813 no 1066 0.344290986577312 1579 1084980 SGTC_2772 vinpocetine 57.06 µM 0.400734268033297 0.319078215004624 no 1067 0.344307889128974 1670 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_565 1418-0001 44.5 µM 0.400179551495869 0.319294539060025 no 1068 0.344512137309912 1696 2862145 SGTC_675 1309-0189 238 µM 0.399552851986405 0.319539008503904 no 1069 0.344742944373254 1591 4246530 SGTC_1654 st012436 41.8 µM 0.398285536605617 0.320033615666858 no 1070 0.345209860302021 1687 4323132 SGTC_225 nsc-122657 1.016 µM 0.396942296857291 0.320558203946919 no 1071 0.345705006311491 1664 275685 SGTC_1157 4092-0394 27.6 µM 0.396870546155784 0.320586235534914 no 1072 0.345731462543482 1704 3659885 SGTC_1242 0402-0103 60.1 µM 0.39673452283085 0.320639379981629 no 1073 0.345781619725674 1583 432868 SGTC_1183 1254-0324 198 µM 0.396386224118973 0.32077547738966 no 1074 0.34591006357989 1708 5799357 SGTC_3003 9075612 71.4286 µM 0.395870974335813 0.320976854956041 no 1075 0.346100107332555 1637 6501993 SGTC_2250 alverine citrate 130 µM 0.394464462505154 0.321526836782369 no 1076 0.346619079717582 1599 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2667 digitoxin 100 µM 0.394325010238116 0.321581387506904 no 1077 0.346670550289898 1700 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1835 st008666 49.2 µM 0.393728072701861 0.321814940090933 no 1078 0.346890906522323 1588 690455 SGTC_803 4488-1585 147 µM 0.393294364278238 0.321984673246827 no 1079 0.347051040110659 1710 747204 SGTC_2139 5578692 56.4705 µM 0.392956509545303 0.322116919498171 no 1080 0.347175801581007 1747 650991 YMR113W FOL3 SGTC_1981 st071826 47 µM 0.391613270815268 0.322642925203292 no 1081 0.347671990443376 1608 11838600 SGTC_390 dec-rvkr-cmk 16.7 µM 0.391378831541958 0.322734766903218 no 1082 0.347758618477056 1672 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2794 7785382 27.27 µM 0.390409644655009 0.323114561052488 no 1083 0.348116828596494 1763 2205081 SGTC_714 4296-0578 26.1 µM 0.389670895854711 0.323404177617379 no 1084 0.348389960184406 1736 1589775 SGTC_1070 indatraline 8.81 µM 0.389449359474203 0.323491048855025 no 1085 0.348471882361813 1604 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_470 aa-861 153 µM 0.389399033535065 0.323510784546992 no 1086 0.34849049343055 1608 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1929 genistein trimethyl ether 50.5 µM 0.389049915750434 0.323647707353233 no 1087 0.34861961094749 1816 136420 SGTC_2869 9037858 32.47 µM 0.384704530898197 0.32535394561541 no 1088 0.350228168959909 1594 27187042 SGTC_2376 9072922 81.32 µM 0.384527407707687 0.32542357199386 no 1089 0.350293793008676 1664 17087968 SGTC_2429 5902844 64.44 µM 0.384347511419426 0.325494294702504 no 1090 0.350360449063929 1768 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1448 4255-0083 152 µM 0.382626674585651 0.326171125277534 no 1091 0.350998294613712 1792 5399660 SGTC_204 PMA1.184 62.41 µM 0.382432416297401 0.32624756596653 no 1092 0.351070324829534 1658 2252213 YGL008C PMA1 SGTC_410 α-linolenic acid 100 µM 0.382428215962278 0.326249218880173 no 1093 0.351071882356534 1727 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2180 6301957 200 µM 0.381105877027498 0.32676975451143 no 1094 0.35156234334103 1742 845462 SGTC_1907 st060210 83.7 µM 0.381024880182563 0.326801649704649 no 1095 0.351592393449111 1745 688793 SGTC_37 0566-0070 1.56 µM 0.380901956269482 0.326850057488903 no 1096 0.351638000415401 1758 1626686 SGTC_3186 9110464 49.47 µM 0.380646507795102 0.326950663139891 no 1097 0.351732783189038 1707 17018021 SGTC_1117 retinoic acid 1.10837 µM 0.380144518984655 0.327148402709741 no 1098 0.351919070267047 1773 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3236 9132701 49.47 µM 0.379979451805613 0.327213435307904 no 1099 0.351980334147672 1610 24282524 SGTC_3257 9139206 32.98 µM 0.379704925176734 0.327321603978859 no 1100 0.352082231879884 1718 4910041 SGTC_943 3253-1379 105 µM 0.379160457051345 0.327536177586377 no 1101 0.352284356871033 1738 668464 SGTC_1717 st033143 58.0435 µM 0.377829592818493 0.328060907794782 no 1102 0.352778594272213 1781 674616 SGTC_1708 st033234 31.827 µM 0.377646049752749 0.328133301413596 no 1103 0.352846775403924 1732 674664 SGTC_2912 7964298 10.93 µM 0.375766187557958 0.328875133700845 no 1104 0.353545363535265 1641 2975850 SGTC_227 fluconazole 33.516 µM 0.375609674635121 0.328936927381475 no 1105 0.353603548636867 1615 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2920 7982904 15.77 µM 0.374871294383463 0.329228514165612 no 1106 0.35387809432125 1623 6456808 SGTC_296 1222-0039 74.9 µM 0.373929009092913 0.329600774067489 no 1107 0.354228566659702 1601 5984176 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.373610888104902 0.329726489328286 no 1108 0.354346916057992 1846 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2606 farnesol 9.78 µM 0.372722080002244 0.330077831032255 no 1109 0.35467765063804 1748 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1147 3809-1045 12.3 µM 0.372436734975415 0.330190658397567 no 1110 0.354783853687738 1636 325925 SGTC_1368 1852-0141 284 µM 0.370698697142479 0.330878223573974 no 1111 0.355430980417474 1679 2838987 SGTC_1874 staurosporine 7.6 µM 0.370186117992423 0.331081108235472 no 1112 0.355621909641953 1736 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_743 1275-0778 158 µM 0.369901537105691 0.331193770009786 no 1113 0.355727928053384 1781 2849257 YMR203W TOM40 SGTC_737 1950-0117 57.9 µM 0.36436410970817 0.333388994665389 no 1114 0.357793066215133 1764 5393513 SGTC_2113 5491891 107.031 µM 0.363636892485358 0.333677714737901 no 1115 0.358064586945553 1612 789979 SGTC_352 k048-0007 5.11 µM 0.363575910763181 0.333701930205072 no 1116 0.358087358925758 1680 6811911 SGTC_884 0851-0618 334 µM 0.363563292949946 0.333706940747675 no 1117 0.358092070771005 1786 9642473 SGTC_1449 4112-4002 201 µM 0.36277639485774 0.334019477104192 no 1118 0.358385963263222 1624 2059539 SGTC_1961 st076550 68.7 µM 0.362636266349185 0.334075144748064 no 1119 0.358438307583946 1698 1579337 SGTC_2522 biochanin a 4.94 µM 0.361753109246662 0.334426072917461 no 1120 0.358768267785705 1739 5280373 A possible chelator. SGTC_2027 5150920 200 µM 0.361519332757138 0.33451898975195 no 1121 0.358855627703635 1747 786715 SGTC_1828 st055811 49 µM 0.361483828577734 0.334533102134592 no 1122 0.358868895903566 1814 5877589 SGTC_567 1080-0542 68.4 µM 0.359767191937449 0.335215718239907 no 1123 0.359510619832773 1775 5950415 SGTC_1506 4226-2149 212 µM 0.35967571809812 0.335252107875047 no 1124 0.359544826299998 1731 991114 SGTC_1464 k208-0027 110 µM 0.359614938622118 0.335276287697128 no 1125 0.359567555291124 1790 X1464 SGTC_2685 mycophenolic acid 18.85 µM 0.358444330353648 0.335742122354099 no 1126 0.360005410839659 1753 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1791 st048313 56.1 µM 0.357696534330599 0.33603983432299 no 1127 0.360285213472959 1815 1204976 SGTC_235 0330-0087 5 mM 0.356962455937995 0.336332185119322 no 1128 0.360559956190725 1688 46494818 YHR062C RPP1 SGTC_1480 1070-0044 41.2 µM 0.355867201382526 0.336768560324554 no 1129 0.360970009733826 1764 3124987 SGTC_3299 9121982 43.1275 µM 0.353775130753394 0.337602701180268 no 1130 0.361753706261679 1659 17594604 YPL160W CDC60 SGTC_532 1548-0774 215 µM 0.353267828138522 0.337805091008047 no 1131 0.361943831012172 1807 5932993 SGTC_193 1273-0060 1.558 µM 0.352489157277088 0.338115835213047 no 1132 0.362235724296765 1758 2847393 YHR072W ERG7 SGTC_1923 st058458 19.1 µM 0.352281423914261 0.338198754023286 no 1133 0.362313608964727 1810 3534982 SGTC_1656 st012921 11 µM 0.351960573371528 0.338326840087903 no 1134 0.362433915419832 1773 6732821 SGTC_1322 1348-1070 12 µM 0.351956461855392 0.338328481558987 no 1135 0.362435457166413 1757 6758089 SGTC_2515 chrysin 20.77 µM 0.351685688421354 0.338436591208359 no 1136 0.362536997375037 1772 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2316 5844804 197.44 µM 0.350558067829459 0.338886950832669 no 1137 0.362959959719318 1837 776813 SGTC_855 0428-0020 25 µM 0.35036163251312 0.338965428581286 no 1138 0.363033658305108 1708 6812414 SGTC_1317 1273-0028 910 nM 0.349128270627904 0.339458327790083 no 1139 0.363496506721215 1691 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3180 9109287 49.47 µM 0.34799489474336 0.339911511010592 no 1140 0.363922008784774 1720 18891271 SGTC_2211 7117706 200 µM 0.347558414750455 0.340086100408572 no 1141 0.364085920784699 1781 822771 SGTC_69 0096-0274 206.684 µM 0.347432444042404 0.340136494320513 no 1142 0.364133231382889 1786 6741392 SGTC_2326 6164455 177.58 µM 0.345654095165212 0.340848217701673 no 1143 0.36480134339863 1689 2888790 SGTC_1230 0170-0365 3.77 µM 0.344659782423091 0.341246404656378 no 1144 0.365175078238396 1785 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_845 0330-0138 4.51 µM 0.343163339009525 0.341846010344295 no 1145 0.365737791569675 1809 9039800 SGTC_2544 sphondin 68.51 µM 0.341963429114934 0.342327087310319 no 1146 0.366189207124522 1796 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2063 5246145 200 µM 0.341673737469573 0.342443271067517 no 1147 0.36629821918876 1754 711240 SGTC_2177 5811945 192 µM 0.341302775424502 0.342592070909926 no 1148 0.366437829367331 1795 5343475 SGTC_173 1273-0061 2.693 µM 0.34091942626941 0.342745865122591 no 1149 0.366582119960726 1640 2847414 YPL266W DIM1 SGTC_3047 9092122 49.47 µM 0.340911932565002 0.342748871749738 no 1150 0.3665849407394 1674 17173831 SGTC_2701 st077767 14.721 µM 0.340147701700869 0.343055549045856 no 1151 0.366872650181365 1713 5721188 SGTC_1067 clotrimazole 1.36 µM 0.339434878757969 0.343341690138785 no 1152 0.367141073545303 1710 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2485 5633444 17.78 µM 0.33858301659025 0.343683762106014 no 1153 0.367461939242086 1657 5724239 SGTC_1338 1486-1223 76 µM 0.337900168610502 0.343958057560057 no 1154 0.367719210246108 1784 3444526 SGTC_1276 0871-0068 94.2 µM 0.337821307527106 0.343989740822001 no 1155 0.367748925912479 1797 3414906 SGTC_2389 9091542 195.52 µM 0.337078940923323 0.344288048004515 no 1156 0.368028696055881 1697 3626624 YOL127W RPL25 SGTC_2851 9015922 71.43 µM 0.336740915504608 0.344423909792025 no 1157 0.368156108371664 1800 2996893 SGTC_2462 5162487 171.77 µM 0.336530752209681 0.34450839036935 no 1158 0.368235332780704 1845 2259986 SGTC_1013 4112-3890 241 µM 0.335692120569577 0.344845577264608 no 1159 0.368551524126709 1691 705171 SGTC_571 k831-0106 44.2 µM 0.334686511937344 0.345250062771455 no 1160 0.368930788581606 1834 4783639 SGTC_1269 0831-0796 3.05 µM 0.333908996258834 0.345562923798447 no 1161 0.369224115502905 1814 927758 SGTC_2399 5884133 200 µM 0.333868321331051 0.345579293705534 no 1162 0.369239462694912 1664 722445 SGTC_1410 3909-8106 77.9 µM 0.332327445860642 0.346199642172342 no 1163 0.369821008825982 1800 1039210 SGTC_3278 9139605 49.47 µM 0.331755212587348 0.346430125550119 no 1164 0.370037052906036 1817 7958859 SGTC_1891 st059073 26.2 µM 0.330894655941549 0.346776846499311 no 1165 0.370362029374738 1867 688754 SGTC_2355 9061122 103.12 µM 0.330036379455191 0.347122776625595 no 1166 0.370686236959067 1851 5302957 SGTC_3337 9144342 33.5465 µM 0.32947808430469 0.34734786707283 no 1167 0.370897178134528 1800 17682949 SGTC_2645 abamectin 100 µM 0.328052748549127 0.347922770374685 no 1168 0.371435889929482 1815 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2393 9031399 185.94 µM 0.327462500731676 0.348160946891216 no 1169 0.37165905046482 1818 1526623 YDL150W RPC53 SGTC_82 0054-0107 293.755 µM 0.326173173056806 0.348681424008329 no 1170 0.372146668622059 1852 3104697 SGTC_783 0848-0141 92.7 µM 0.321210624950515 0.350687361919783 no 1171 0.374025390447207 1727 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2764 methyldopa 94.69 µM 0.320855417709785 0.350831102696961 no 1172 0.374159980263799 1866 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3199 9111318 49.47 µM 0.32075824433003 0.350870429312857 no 1173 0.374196802420865 1820 8548020 SGTC_151 3013-0144 2.285 µM 0.32017151716734 0.35110791504451 no 1174 0.374419156818844 1853 906558 YHR107C CDC12 SGTC_3252 9135871 49.47 µM 0.319901106242017 0.351217387098884 no 1175 0.374521649622852 1805 17682838 SGTC_2386 9075165 157.42 µM 0.319504631579862 0.351377916601099 no 1176 0.374671939904351 1763 16452277 SGTC_1744 st037937 38.9 µM 0.319371412128431 0.35143186207213 no 1177 0.374722443216459 1797 1016152 SGTC_3284 9108171 64.8615 µM 0.319242235960491 0.351484173126369 no 1178 0.374771415777275 1751 8687505 SGTC_415 dibenzyl ketone 100 µM 0.319198372830033 0.35150193653644 no 1179 0.374788045386249 1868 7593 SGTC_1652 st011932 78 µM 0.317318030319793 0.352263730099073 no 1180 0.375501148777373 1825 1551076 SGTC_113 0099-0221 2.5 µM 0.317309668382164 0.352267119144058 no 1181 0.37550432092106 1850 89219 SGTC_801 0866-0028 10.1 µM 0.316338487834863 0.352660812747308 no 1182 0.375872800419075 1760 6849771 SGTC_3269 9137823 49.47 µM 0.315730974974012 0.352907164366604 no 1183 0.37610335688925 1714 17682936 SGTC_1101 ebselen 5.29 µM 0.314373254063487 0.35345795453988 no 1184 0.376618783666976 1895 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_440 fluspirilene 35.1 µM 0.313820602388864 0.35368223816595 no 1185 0.376828647925783 1830 3396 An atypical antipsychotic. SGTC_2624 nerol 100 µM 0.313184207817834 0.353940570249957 no 1186 0.377070357847902 1837 637566 A natural product oil. SGTC_1645 Cervolide 78 µM 0.312990222518676 0.35401932821535 no 1187 0.377144045264163 1753 23173 A fragrance. SGTC_670 4204-0025 119 µM 0.312109508954726 0.354376976130287 no 1188 0.377478650078027 1830 719039 SGTC_1056 3448-1962 115 µM 0.310425445820195 0.355061212743134 no 1189 0.378118723136529 1795 715507 SGTC_1531 st059297 52.4 µM 0.309441519476405 0.355461199635817 no 1190 0.37849284556357 1794 7566702 SGTC_2589 lobaric acid 100 µM 0.308350382042826 0.355904956325377 no 1191 0.378907866519804 1697 73157 A novel microtubule depolymerizer. SGTC_171 k064-0041 9.68 µM 0.307987749622117 0.356052479240449 no 1192 0.379045826974148 1709 53325 SGTC_758 0868-0029 16 µM 0.307952498948969 0.356066820757327 no 1193 0.379059238618264 1888 762687 SGTC_2359 9039622 200 µM 0.305863207625778 0.356917199007195 no 1194 0.379854400162642 1833 6463596 SGTC_512 prima-1 270 µM 0.303268819022916 0.357974150657834 no 1195 0.380842503363032 1851 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1591 genipin 88.4 µM 0.302717530836351 0.358198885626843 no 1196 0.381052568302885 1834 442424 A DNA cross-linking agent. SGTC_3205 9113483 49.47 µM 0.301856384509793 0.358550033883693 no 1197 0.3813807728968 1883 17018033 SGTC_674 0498-0004 451 µM 0.300546124982686 0.359084545705734 no 1198 0.381880309468833 1736 4231473 SGTC_76 0433-0009 400.328 µM 0.29996613803297 0.359321235777967 no 1199 0.382101492418275 1767 2841569 SGTC_2888 9058547 12.99 µM 0.297512148396078 0.360323294519748 no 1200 0.383037767292811 1733 16476514 SGTC_2748 diazoxide 86.69 µM 0.297271902675572 0.360421447841065 no 1201 0.383129465487433 1847 3019 A potassium channel activatior. SGTC_1093 fluphenazine 7.97 µM 0.297234123091989 0.36043688367371 no 1202 0.383143885984902 1807 6602611 An atypical antipsychotic. SGTC_1462 k081-0014 26.5 µM 0.296025864328595 0.360930669092182 no 1203 0.38360516463082 1712 3270634 SGTC_3324 9138759 60.749 µM 0.295925974428038 0.360971502008171 no 1204 0.383643307132079 1806 45595710 SGTC_7 0192-1582 4.227 µM 0.295148014230953 0.361289570167496 no 1205 0.383940406230712 1813 252616 SGTC_286 k060-0067 22.9 µM 0.29446641184119 0.361568321380141 no 1206 0.38420076284491 1780 5985051 SGTC_1627 st003713 25.6 µM 0.294397072671198 0.361596682762962 no 1207 0.384227251761702 1758 16195070 YER133W GLC7 SGTC_1837 st055472 66.5 µM 0.293746273395125 0.36186291231023 no 1208 0.384475896130851 1838 676091 SGTC_3157 9099274 49.47 µM 0.293417321716775 0.361997505604239 no 1209 0.384601593500834 1926 17217662 SGTC_649 1123-0311 367 µM 0.293295042460737 0.36204754152348 no 1210 0.384648321332502 1886 693629 YIL048W NEO1 SGTC_893 0958-0369 48.9 µM 0.293136144985754 0.36211256491504 no 1211 0.384709044965085 1927 6819948 SGTC_364 0083-0097 67.7 µM 0.292651169794732 0.362311049131899 no 1212 0.384894398656936 1778 5207356 SGTC_3012 9080433 71.4286 µM 0.292575960099482 0.362341833276085 no 1213 0.384923145566447 1937 17688859 SGTC_2174 5790901 200 µM 0.291666445101164 0.362714178054039 no 1214 0.385270833566242 1791 786020 SGTC_127 0180-0333 59.125 µM 0.290720083680469 0.363101745182719 no 1215 0.385632705082584 1882 771601 SGTC_1570 verbenone 133 µM 0.288503412984261 0.364010095383063 no 1216 0.386480709173239 1935 29025 A natural terpanoid with antifungal properties. SGTC_3319 9138450 16.7555 µM 0.288133518454861 0.364161745822128 no 1217 0.386622268033201 1797 2029690 SGTC_2037 5169046 200 µM 0.287909354379922 0.364253659617384 no 1218 0.386708063103754 1846 5718022 SGTC_258 haloperidol 50.781 µM 0.287845477658213 0.364279852362101 no 1219 0.386732511870281 1755 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_284 0988-0104 32.6 µM 0.287101720494287 0.364584877722011 no 1220 0.387017217423484 1870 4666532 SGTC_2248 tofa 1.1 µM 0.286059014565277 0.365012650561792 no 1221 0.387416461016604 1824 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_329 k048-0121 21.3 µM 0.285875780340963 0.365087840258498 no 1222 0.387486632221347 1789 6832902 SGTC_71 0417-1750 47.813 µM 0.28526177258432 0.36533983457611 no 1223 0.387721798833393 1953 6811472 SGTC_732 3970-1727 52.7 µM 0.283841573362669 0.365922919765239 no 1224 0.388265896627868 1938 1275699 SGTC_3139 9095020 49.47 µM 0.283101152496101 0.366227034190096 no 1225 0.388549649077585 1814 25236292 SGTC_2287 7945887 168.79 µM 0.28285656058882 0.366327514350425 no 1226 0.388643397429494 1942 1245853 SGTC_1487 3970-0795 2.82 µM 0.27956370598515 0.367681133013567 no 1227 0.389906127791491 1854 3765103 SGTC_1073 triclabendazole 3.09 µM 0.278494347637648 0.368121076984278 no 1228 0.390316451711388 1821 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1231 0242-0792 125 µM 0.278103807224136 0.368281792105079 no 1229 0.390466336620696 1769 3707635 SGTC_153 4077-0274 519.67 µM 0.277837597053663 0.368391356080195 no 1230 0.39056851434782 1951 3121976 SGTC_866 0495-0101 262 µM 0.277817543559051 0.36839960991965 no 1231 0.390576211657079 1728 635694 SGTC_179 1273-0063 6.77 µM 0.277406085886384 0.368568975627566 no 1232 0.390734154537951 1763 3108139 SGTC_3232 9132874 49.47 µM 0.274194420274017 0.369891848349269 no 1233 0.391967607922207 1775 3784940 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.270590638333259 0.371378066722468 no 1234 0.39335294841685 1790 2374 Ca(2+)-ATPase inhibitor. SGTC_1400 3771-8998 51.5 µM 0.270330697789291 0.371485342045613 no 1235 0.393452925391455 1873 670767 SGTC_3019 9081971 49.47 µM 0.269062739194093 0.372008761090318 no 1236 0.393940701606785 1955 16451803 SGTC_2056 5235370 200 µM 0.268001472151097 0.372447038879622 no 1237 0.39434909278051 1790 5511916 SGTC_3170 9103054 49.47 µM 0.267959759643428 0.372464268521588 no 1238 0.394365146742778 1814 16432970 SGTC_1404 3909-7820 48.3 µM 0.26784219505285 0.37251283076837 no 1239 0.394410394987967 1937 23741373 SGTC_2473 5854593 8.94 µM 0.266909146607986 0.372898315649114 no 1240 0.394769557038791 1811 2872951 SGTC_1327 1436-0082 2.18 µM 0.266589348257253 0.373030468251395 no 1241 0.394892678890038 1835 15992205 SGTC_1967 st070177 51.4 µM 0.266338441469499 0.373134162751947 no 1242 0.394989284949573 1901 5729214 SGTC_261 5-fluorouridine 15.376 µM 0.265250927963831 0.373583715375852 no 1243 0.395408082318127 1920 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1895 st058434 18.3 µM 0.264551479973781 0.373872941768709 no 1244 0.395677500987718 1968 5393175 SGTC_722 3534-0461 190 µM 0.263000308420536 0.374514614744306 no 1245 0.396275170698077 1802 658262 SGTC_108 0509-0257 621.132 µM 0.262486143368511 0.374727386158789 no 1246 0.396473333471698 1929 536624 SGTC_1880 MG-132 525 µM 0.262465174751139 0.374736064186956 no 1247 0.396481415490073 1945 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2010 4012422 159 µM 0.261758138597227 0.375028713796677 no 1248 0.396753957287877 1871 952393 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.26010962811701 0.375711328650074 no 1249 0.397389605659377 1981 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3136 9095672 49.47 µM 0.258549236997367 0.37635781367401 no 1250 0.39799152730581 2007 17217380 SGTC_407 eburnamonine 100 µM 0.257548812320065 0.37677248191104 no 1251 0.398377569488255 1820 3195 SGTC_1079 idarubicin 2.36 µM 0.255347788039015 0.377685289320721 no 1252 0.399227246699748 1968 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2859 9028643 45.46 µM 0.255336444180283 0.377689995613474 no 1253 0.399231627091604 1939 17151580 SGTC_1856 st057054 55.7 µM 0.255199219497506 0.377746928255148 no 1254 0.399284616933657 1985 1266018 SGTC_2480 5767542 37.17 µM 0.254647506076795 0.377975853391114 no 1255 0.399497681924517 1890 2867358 SGTC_626 0214-0009 33 µM 0.254519101343755 0.37802913914283 no 1256 0.399547274562212 1934 3437874 SGTC_2022 5136654 200 µM 0.252735057938286 0.378769726087124 no 1257 0.400236477411064 1869 1713771 SGTC_894 0960-0238 55.9 µM 0.252187524241239 0.378997106136545 no 1258 0.400448060358967 1968 6741907 YDL195W SEC31 SGTC_3128 9127691 49.47 µM 0.252017931646209 0.379067543126869 no 1259 0.400513601800253 1864 41316314 SGTC_474 dl-dihydrosphingosine 5 µM 0.250406850840676 0.379736874208876 no 1260 0.401136366073292 1941 3058739 A sphingolipid protein kinase C inhibitor. SGTC_310 1273-0058 1.06 µM 0.25029255362658 0.379784373240623 no 1261 0.401180557295486 1920 2734232 SGTC_418 lividomycin a 100 µM 0.250160016237109 0.379839454699095 no 1262 0.401231802377852 1963 72394 An antibiotic. SGTC_1829 berberine 14.4 µM 0.249659688000299 0.380047408999019 no 1263 0.401425267712358 1964 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_452 diindolylmethane 8 µM 0.249558076129624 0.380089646764014 no 1264 0.401464561621966 1913 3071 Inhibits expression of several cancer promoting factors. SGTC_1004 4084-0029 199 µM 0.247944280933988 0.380760656476964 no 1265 0.402088759068437 1983 716894 YLR208W SEC13 SGTC_747 3448-8087 38.7 µM 0.247557013516303 0.38092173421162 no 1266 0.40223858688205 1827 5168703 SGTC_357 1325-0123 420 µM 0.247421058078445 0.380978287613749 no 1267 0.402291189359786 1992 1098503 SGTC_431 k089-0097 107 µM 0.246447960674836 0.381383141232001 no 1268 0.402667741787373 1897 5499420 SGTC_2411 st077133 39.94 µM 0.245051852618601 0.381964213548641 no 1269 0.403208141225682 2016 1403142 YNL221C POP1 SGTC_1911 st060208 74.3 µM 0.243901764955716 0.382443089931963 no 1270 0.403653451109082 1948 688783 SGTC_795 0685-0265 78 µM 0.242816891863228 0.382894976957267 no 1271 0.404073624656044 1858 302754 SGTC_98 0074-0023 107.663 µM 0.242506405048387 0.383024334786631 no 1272 0.404193897223363 1824 3563821 SGTC_456 gingerol 170 µM 0.24077663726668 0.383745244743058 no 1273 0.404864118877863 1904 442793 A herb. SGTC_2124 5246320 200 µM 0.240755936214826 0.383753874698809 no 1274 0.404872141471594 1895 579342 SGTC_2808 7946468 45.46 µM 0.240423817029033 0.383892338049485 no 1275 0.405000858139497 1901 2970879 SGTC_2798 7813637 45.45 µM 0.239155821484021 0.384421112513091 no 1276 0.405492379032107 1912 956368 SGTC_1693 xanthone 101.9 µM 0.237161117428729 0.385253371162796 no 1277 0.406265899829653 1944 7020 An insecticide. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.236478315031648 0.385538381315833 no 1278 0.406530766127182 1987 688662 SGTC_2292 7671323 168.05 µM 0.2356816686989 0.385870989464139 no 1279 0.406839847749753 1872 937504 SGTC_3260 9137109 49.47 µM 0.235179736048109 0.386080594688542 no 1280 0.407034616624521 2001 17478346 SGTC_2223 6903751 107.57 µM 0.234076060284916 0.386541602500719 no 1281 0.407462965410607 1950 5598863 SGTC_603 3794-0023 45.9 µM 0.232976535764386 0.387001035613184 no 1282 0.407889813106073 2002 3802260 SGTC_2041 5107442 45.335 µM 0.232470284993038 0.387212624304922 no 1283 0.40808638210434 1992 793005 SGTC_1272 0839-0021 27 µM 0.231674433593931 0.387545319989781 no 1284 0.408395445103141 1914 5027250 SGTC_10 0279-0212 42.575 µM 0.231402870086815 0.387658862616388 no 1285 0.408500917830841 1926 39851 YBR002C RER2 SGTC_537 1334-0398 209 µM 0.231318291570057 0.387694227456173 no 1286 0.408533768690134 2023 5846986 SGTC_266 formosanin C 406 nM 0.228377735040762 0.388924340569485 no 1287 0.409676298494076 1994 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_308 4092-1169 104 µM 0.228302858711629 0.388955677932985 no 1288 0.409705401155522 1936 2268590 YDL196W YDL196W SGTC_1225 1216-0074 20.6 µM 0.226585831466911 0.389674488828687 no 1289 0.41037290530964 1872 4241466 SGTC_1803 st050068 52.4 µM 0.226548096449081 0.389690290346838 no 1290 0.410387577937247 1949 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.226220698994703 0.389827395503852 no 1291 0.410514886199141 1990 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1035 k081-0041 55.2 µM 0.226034579859013 0.389905343253466 no 1292 0.41058726269428 2025 731709 SGTC_555 4296-0685 37 µM 0.22254742246029 0.391366599939729 no 1293 0.411943880458901 1941 2908540 YHR072W ERG7 SGTC_26 0302-0163 425.158 µM 0.221739624344569 0.391705318914552 no 1294 0.412258291047574 1923 3100915 SGTC_2880 9042983 58.44 µM 0.220714499864085 0.392135283508331 no 1295 0.412657370308948 1911 6464714 SGTC_2691 st077356 60.2 µM 0.22070102228269 0.392140937244539 no 1296 0.412662617711365 1969 2839272 SGTC_2703 st077852 53.4 µM 0.220408084614672 0.39226382784725 no 1297 0.412776674806452 1918 6281836 SGTC_1266 0828-0227 32.9 µM 0.220396613389451 0.392268640372248 no 1298 0.412781141348929 1947 3913820 SGTC_1672 st016598 6.51 µM 0.217958857937733 0.393291725013066 no 1299 0.413730583677108 1880 4665860 YNL267W PIK1 SGTC_2549 cedrol 20.94 µM 0.217809896552499 0.39335426555655 no 1300 0.413788616674995 2018 6708665 A sedative which affects the nervous system. SGTC_2273 7815444 169.05 µM 0.215267599957557 0.394422056526481 no 1301 0.414779344468607 2060 2824616 SGTC_1131 3454-3128 32.3 µM 0.213715511156731 0.395074340740613 no 1302 0.415384457320972 1968 710982 SGTC_1728 st035614 33.7865 µM 0.2128664226431 0.395431305124086 no 1303 0.415715576496357 1912 15945546 SGTC_1805 st050013 60.3 µM 0.212623617879935 0.39553339855969 no 1304 0.415810274121223 2000 4037144 SGTC_1871 st057448 67.3 µM 0.211408968307772 0.396044236361319 no 1305 0.416284079597574 1996 691747 SGTC_1753 st043925 64 µM 0.210938730120147 0.396242049579966 no 1306 0.416467540872466 2048 670181 SGTC_2329 6138490 200 µM 0.210431477808392 0.396455463335033 no 1307 0.416665463440992 1904 720019 SGTC_1806 st050005 60.3 µM 0.209579401888445 0.396814022824211 no 1308 0.416997978758348 1879 5194765 SGTC_52 0329-0193 875 nM 0.208964676247511 0.397072757863375 no 1309 0.417237907054949 2014 3739292 SGTC_3041 9091929 49.47 µM 0.206328724705344 0.398182729421143 no 1310 0.418267071080521 1996 25236887 SGTC_1486 3970-0793 4.53 µM 0.20611056868763 0.398274629694136 no 1311 0.418352271697722 2052 2844330 SGTC_3281 9140613 49.47 µM 0.204862874666575 0.398800340805103 no 1312 0.41883963086044 1856 16013766 SGTC_2743 auranofin 4.32 µM 0.203171164167741 0.399513429726563 no 1313 0.419500625219558 2010 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.199683140948513 0.400984755501527 no 1314 0.420864199902066 1977 5393153 SGTC_744 1594-0068 283 µM 0.199264200389759 0.401161568902595 no 1315 0.421028040768878 1920 668392 SGTC_2088 5278280 127.392 µM 0.198671223664518 0.401411868674372 no 1316 0.421259967736312 1973 791502 SGTC_1899 st063254 59.6 µM 0.198150888190087 0.401631539380299 no 1317 0.4214635055347 1881 3093813 SGTC_851 0394-0702 453 µM 0.198109973615813 0.401648813658699 no 1318 0.421479510835569 2079 762646 SGTC_345 1362-0200 395 µM 0.198006572779713 0.401692470714998 no 1319 0.421519960606266 1884 1419823 SGTC_213 1246-0773 967 nM 0.197836890023864 0.401764115440441 no 1320 0.42158634125049 1993 6251622 SGTC_3025 9087895 49.47 µM 0.197350577716658 0.40196946815272 no 1321 0.421776601114007 2067 17173641 SGTC_2555 cholic acid 100 µM 0.197253446416434 0.402010486554923 no 1322 0.421814603961776 1982 6708657 Influences liver metabolism. SGTC_1866 st057638 64 µM 0.196631050435433 0.402273349039976 no 1323 0.422058135107352 1937 688802 SGTC_102 gallobenzophenone 83.616 µM 0.196226230801196 0.402444344143925 no 1324 0.422216548967289 2051 70837 SGTC_545 4218-0007 221 µM 0.192599844610554 0.403976952232615 no 1325 0.423636183316041 1972 2840508 SGTC_2314 7727897 200 µM 0.192022961923914 0.404220894942213 no 1326 0.423862109549488 1912 900724 SGTC_3059 1327-0034 3 µM 0.189595117127246 0.405247949387887 no 1327 0.424813206889938 1939 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_890 0929-0006 47.2 µM 0.188891050126062 0.40554591422616 no 1328 0.425089104135662 1907 1378169 SGTC_930 2810-3379 265 µM 0.188181221610367 0.405846372784719 no 1329 0.425367296246986 2090 1015764 SGTC_464 bw-b 70c 158 µM 0.187332755803239 0.40620558696258 no 1330 0.42569987107462 2062 5353454 SGTC_754 3474-0146 171 µM 0.187178868553801 0.406270746532515 no 1331 0.425760196235838 1863 24762078 SGTC_3244 9134489 49.47 µM 0.185886028840518 0.40681826837029 no 1332 0.426267069311545 1936 16584271 SGTC_3272 9137413 49.47 µM 0.185704774855562 0.406895044610219 no 1333 0.426338141832615 2085 17614870 SGTC_577 r071-0003 38.6 µM 0.185565738266862 0.406953940673082 no 1334 0.426392661874132 2018 4568517 YMR134W ERG29 SGTC_600 1495-0418 41.6 µM 0.18412910333534 0.407562623891808 no 1335 0.42695608781849 1982 5377768 SGTC_2322 7413319 38.22 µM 0.183329187875297 0.407901634340102 no 1336 0.427269866935293 1977 1840400 SGTC_16 erodoxin 22.806 µM 0.182906224231765 0.408080917541214 no 1337 0.427435799528142 2041 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1859 st055998 20 µM 0.182167015272895 0.40839429503121 no 1338 0.427725828921992 2116 676301 SGTC_3253 9135987 49.47 µM 0.181688650206508 0.408597122573466 no 1339 0.427913536772526 2029 4182430 SGTC_525 k781-2675 26.7 µM 0.181419575175065 0.408711221574115 no 1340 0.428019127523711 2121 3651118 YDL195W SEC31 SGTC_2277 7947813 106.88 µM 0.181189910192198 0.408808615196662 no 1341 0.428109257013403 2065 1246798 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.180624974000455 0.409048210637525 no 1342 0.428330975942027 1970 6708760 SGTC_1884 5633444 25 µM 0.180364573167184 0.409158660846104 no 1343 0.428433182351695 2007 5724239 SGTC_821 1114-0266 29.2 µM 0.180255172315308 0.409205065871637 no 1344 0.42847612323307 1970 3123235 SGTC_2780 5215298 71.43 µM 0.180012166141627 0.40930814738715 no 1345 0.428571508510712 2128 2834131 SGTC_2769 toremifene 3.73 µM 0.179998857176522 0.409313793138056 no 1346 0.42857673269334 2004 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1371 2421-0008 32.7 µM 0.17991957546213 0.409347425354694 no 1347 0.4286078534907 1948 2827552 SGTC_2018 5133068 143 µM 0.179500526740979 0.409525201728049 no 1348 0.428772351883713 1989 785362 SGTC_2495 cafestol 54.53 µM 0.177800695465101 0.410246525113851 no 1349 0.429439750575036 2024 16667697 An anti-infammatory. SGTC_1357 1503-1303 39.5 µM 0.177755643757308 0.41026564694845 no 1350 0.429457441818897 2008 292895 SGTC_1657 st012939 43.4 µM 0.177377214377747 0.410426276669891 no 1351 0.429606051907111 2096 24207257 SGTC_738 1315-0003 72.4 µM 0.177275356587234 0.410469514222632 no 1352 0.429646053400591 2090 6251474 SGTC_3119 9125183 49.47 µM 0.176965945238934 0.410600862732612 no 1353 0.42976756955552 2099 22695334 SGTC_3240 9133527 49.47 µM 0.175009733782664 0.411431527459867 no 1354 0.430535992586959 1989 17617455 SGTC_2996 9066192 71.4286 µM 0.174772714453545 0.411532199865233 no 1355 0.430629114515091 1925 6472854 SGTC_1171 0368-0077 21.4 µM 0.173819579124983 0.411937096586952 no 1356 0.431003628353123 1976 3239779 SGTC_1523 st012844 44.7 µM 0.173009883019615 0.41228113328475 no 1357 0.431321829622308 1999 4274103 SGTC_86 0417-1630 471.922 µM 0.172576830312437 0.412465163368524 no 1358 0.431492032671843 2107 3634867 SGTC_1189 1431-2119 7.28 µM 0.170824555121086 0.413210006342837 no 1359 0.432180860332835 2073 3107275 SGTC_1722 st034304 3.6505 µM 0.170602018574754 0.413304622798042 no 1360 0.432268355301692 1976 4036148 YLR033W RSC58 SGTC_2152 5568786 200 µM 0.170600681015451 0.413305191506916 no 1361 0.432268881201583 2062 5399883 SGTC_2094 5332512 191.667 µM 0.17015050534852 0.413496609343467 no 1362 0.432445887517444 2090 755774 SGTC_1435 4092-0789 56.7 µM 0.169806036133652 0.413643093946797 no 1363 0.432581339862359 2110 2248285 SGTC_2848 9016370 25.97 µM 0.168894527936445 0.414030768273996 no 1364 0.432939801720451 2132 7894410 SGTC_1114 scopoletin 1.73284 µM 0.167953045035738 0.414431279133145 no 1365 0.433310109438783 2123 5280460 A coumarin with genotoxic properties. SGTC_315 k915-0449 187 µM 0.16409875304667 0.41607183498486 no 1366 0.43482670171588 2041 20970215 YNL149C PGA2 SGTC_2215 7188065 200 µM 0.163300078186881 0.416411970057515 no 1367 0.435141086172344 2108 940217 SGTC_161 4065-0411 162.148 µM 0.161780804894473 0.417059162065451 no 1368 0.435739234688571 2017 1906281 YLR208W SEC13 SGTC_2819 7996655 46.38 µM 0.161299202208091 0.417264365984611 no 1369 0.435928875789432 2093 6456960 SGTC_704 1310-0270 142 µM 0.160923081586299 0.417424641202916 no 1370 0.436076991375458 1981 5718033 SGTC_236 1509-0011 5.31 µM 0.160863465232765 0.417450046611684 no 1371 0.436100469005825 2083 3107280 SGTC_2891 9063876 19.48 µM 0.159826142897911 0.417892154853833 no 1372 0.436509014872592 2181 6472478 SGTC_1260 0700-1617 7.75 µM 0.15915213109107 0.418179475299381 no 1373 0.436774508459141 2026 2853078 SGTC_2882 9058044 58.44 µM 0.159007742344806 0.418241031595632 no 1374 0.436831386966418 1947 18076804 SGTC_156 3474-0145 5.642 µM 0.158854823720767 0.41830622656163 no 1375 0.436891627039722 2144 2265471 SGTC_3126 9127922 49.47 µM 0.156559914034891 0.419284901571393 no 1376 0.437795848415274 2051 45595682 SGTC_3332 9141069 11.198 µM 0.155100116172657 0.419907699580642 no 1377 0.438371195300728 1975 17332883 SGTC_950 1165-0508 94.1 µM 0.15483319531599 0.420021598581347 no 1378 0.438476410348442 1993 6148369 SGTC_1009 4106-0057 9.87 µM 0.154087925720958 0.420339651360715 no 1379 0.43877020422969 2170 2928005 SGTC_449 xestospongin c 11.1929 µM 0.154028296010401 0.420365101308508 no 1380 0.438793712410144 2073 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1572 epiandrosterone 68.9 µM 0.153840827249248 0.420445115104105 no 1381 0.438867620756669 2052 441302 A steroid. SGTC_1420 4'-methoxyflavone 42 µM 0.151683422924917 0.421366155553661 no 1382 0.43971831623124 2138 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_585 0kpi-0023 191 µM 0.151357472842725 0.421505347925741 no 1383 0.439846867330763 2127 64601 SGTC_3068 9116768 49.47 µM 0.150020454653158 0.422076405088935 no 1384 0.440374238704245 2046 41904888 SGTC_1221 2958-7315 257 µM 0.150000625898509 0.422084875433731 no 1385 0.440382060725744 2064 4562705 SGTC_1019 4262-0212 3.4 µM 0.149108624446191 0.422465953217369 no 1386 0.440733960323818 2156 4677213 SGTC_1039 k821-0043 94 µM 0.148149493524797 0.422875790796673 no 1387 0.441112395091963 2134 15992768 SGTC_1068 loratadine 26.9 µM 0.14773751678118 0.423051854519316 no 1388 0.441274961197077 2016 3957 A H1 histamine antagonist. SGTC_2938 9059746 27.26 µM 0.146158688693059 0.423726729645246 no 1389 0.441898058460185 2084 6471769 SGTC_1754 st042065 16.137 µM 0.145328775899312 0.42408156838843 no 1390 0.442225648008756 2072 1126236 YIL048W NEO1 SGTC_1066 ketoconazole 628 nM 0.143688067384583 0.424783253021865 no 1391 0.442873397130582 2116 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2754 granisetron 64.02 µM 0.142785784978746 0.425169235438108 no 1392 0.443229681992436 2136 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1993 st073995 70.8 µM 0.142423949126802 0.425324043376761 no 1393 0.443372573270626 2071 3098394 SGTC_2507 purpurin 79.67 µM 0.141961656845616 0.425521847368477 no 1394 0.443555146143323 1969 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_975 1335-0046 28.5 µM 0.141852877825921 0.425568394078342 no 1395 0.443598107933159 1995 16486740 SGTC_1495 4469-0029 237 µM 0.141631577047111 0.42566309222318 no 1396 0.443685511736795 2115 793680 SGTC_3151 9099821 49.47 µM 0.140771729800037 0.426031075269074 no 1397 0.444025138492383 2055 17174189 SGTC_1057 3448-5381 134 µM 0.140751117783684 0.42603989724704 no 1398 0.444033280434993 2136 5497911 SGTC_2752 diclazuril 33.15 µM 0.140360975123821 0.426206885943282 no 1399 0.444187394949417 2158 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_586 0957-0265 8.15 µM 0.139849572981258 0.426425796107179 no 1400 0.444389422275251 2164 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_128 0906-2981 13.371 µM 0.139687051825751 0.426495369460446 no 1401 0.444453628621444 2160 6740226 SGTC_1569 carminic acid 40.6 µM 0.139108873557439 0.426742899156345 no 1402 0.444682058160763 2159 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2207 7258803 200 µM 0.138921685949436 0.426823044107712 no 1403 0.444756017110548 2140 3666799 SGTC_3249 9135183 49.47 µM 0.138855025058668 0.426851585903251 no 1404 0.444782355693976 2094 4902779 SGTC_2995 9067767 71.4286 µM 0.138779194446924 0.426884054309101 no 1405 0.444812317649617 2067 11673567 SGTC_1112 tnp00069 1.16933 µM 0.138737111428967 0.426902073215775 no 1406 0.444828945496943 2143 145826 SGTC_396 dithiazanine 1.25 µM 0.138355304168911 0.427065560599607 no 1407 0.444979809661794 2000 10578 An antihelmenthic. SGTC_535 2293-4129 48.2 µM 0.138011958692501 0.427212589597652 no 1408 0.445115483161799 2150 396118 YIL048W NEO1 SGTC_2093 5331342 194.4 µM 0.137952681252228 0.427237974683145 no 1409 0.445138907385929 2154 33839 SGTC_576 1073-0113 22.7 µM 0.137939618497201 0.427243568743099 no 1410 0.445144069323203 2185 5439563 SGTC_1975 st070967 30.8 µM 0.137818794335827 0.427295311783372 no 1411 0.44519181518529 2194 261391 SGTC_2245 6637752 200 µM 0.137198118562081 0.427561136358924 no 1412 0.445437099009295 2158 681890 SGTC_2760 etidronate 98.04 µM 0.134681085715553 0.428639473380936 no 1413 0.446432014167019 2077 3305 A chelator and antioxidant. SGTC_2420 aureobasidin a 50 nM 0.134295759538406 0.428804600500877 no 1414 0.446584353133676 2145 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3188 9110789 49.47 µM 0.133812032176544 0.429011913961273 no 1415 0.446775606233305 2159 849217 SGTC_1017 4239-0030 168 µM 0.132812387448744 0.429440398706801 no 1416 0.447170878692374 1972 1149593 SGTC_965 1291-5240 308 µM 0.131352761923696 0.430066197454464 no 1417 0.447748127664975 2153 2834598 SGTC_2447 5741742 33.78 µM 0.130765311493972 0.430318110190299 no 1418 0.447980482365254 2118 1776504 SGTC_1411 3909-8223 150 µM 0.130385875572118 0.430480836433912 no 1419 0.448130570427248 2192 X1411 SGTC_129 0088-0017 176.636 µM 0.129993978413812 0.430648919241675 no 1420 0.448285595398078 2184 182446 SGTC_3207 9114163 49.47 µM 0.129858489454724 0.430707032729428 no 1421 0.448339193368771 2191 849233 SGTC_2541 muurolladie-3-one 83.07 µM 0.129521613293691 0.430851531068019 no 1422 0.448472462029411 2135 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2679 rapamycin 1 nM 0.12891660857636 0.431111062647247 no 1423 0.448711817295621 2095 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_259 usnic acid 108.925 µM 0.128457411694028 0.431308066252011 no 1424 0.448893499737908 2157 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.128113157255529 0.431455768721422 no 1425 0.449029711934059 2154 2333 A French combination drug. SGTC_366 0181-0206 4.31 µM 0.127626269052769 0.431664684609441 no 1426 0.449222370716757 2193 274874 SGTC_2796 7949634 45.45 µM 0.127494943052681 0.431721037757165 no 1427 0.449274337690379 2118 2971588 SGTC_3058 9093861 49.47 µM 0.127307137868872 0.431801629036148 no 1428 0.449348655537174 2140 17217477 SGTC_3000 9075062 71.4286 µM 0.126828683271951 0.432006957103537 no 1429 0.449537996542551 2063 17057871 SGTC_1514 1189-1591 158 µM 0.125838626631959 0.432431896683485 no 1430 0.44992983258139 2166 767698 YMR146C TIF34 SGTC_1675 st018485 24.5 µM 0.124876338894831 0.432844992562301 no 1431 0.450310725273923 2045 3323024 SGTC_2240 6690706 185.951 µM 0.124629647377887 0.432950905416777 no 1432 0.450408378085224 1997 805876 SGTC_312 4092-0653 6.84 µM 0.124593869881376 0.432966266283383 no 1433 0.450422540852925 2160 1148278 SGTC_1293 1000-1278 195 µM 0.122456780055902 0.433883996676283 no 1434 0.451268636418017 2151 678847 SGTC_1392 3455-1037 33.9 µM 0.121337646814904 0.434364728566218 no 1435 0.451711801223725 2155 981132 SGTC_1524 corynanthine 62.1 µM 0.121332794960491 0.434366812927707 no 1436 0.451713722637649 2100 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.121215932639041 0.434417017648498 no 1437 0.451760002375261 2074 75037 A free radical scavenger. SGTC_769 0302-0231 76 µM 0.120704473353889 0.434636755912679 no 1438 0.451962557841016 2165 571869 YER009W NTF2 SGTC_2101 5377231 179.231 µM 0.11981935918508 0.435017075205152 no 1439 0.452313123006737 2141 2844213 SGTC_1376 2910-0861 41.3 µM 0.119033345085847 0.435354863214236 no 1440 0.452624469010128 2175 1112859 SGTC_2770 toltrazuril 17.5 µM 0.118965969714326 0.435383819845988 no 1441 0.452651158251807 2204 68591 Kills coccidiodes. SGTC_887 0885-0007 9.62 µM 0.116543076910839 0.436425361402644 no 1442 0.453611074117107 2178 5719458 SGTC_1685 st024049 53.0905 µM 0.115835743027856 0.436729510181546 no 1443 0.453891361169268 2122 1941139 SGTC_2643 anethole 100 µM 0.115256962318275 0.436978409801293 no 1444 0.454120725026573 2126 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_646 4092-0839 27.3 µM 0.114840241174109 0.437157632565426 no 1445 0.454285876099476 2157 877796 SGTC_1750 st081859 2.357 µM 0.114231324797767 0.437419537529178 no 1446 0.454527210415099 2141 5291695 SGTC_94 0334-0113 514.748 µM 0.111808727600714 0.438461806978034 no 1447 0.455487533647108 2183 6795178 SGTC_2955 9076254 12.21 µM 0.11165036214842 0.438529955194837 no 1448 0.455550319204647 2197 16459619 SGTC_295 k015-0027 31 µM 0.110956681092989 0.438828483208484 no 1449 0.455825349014318 2138 3887424 SGTC_3076 9116187 49.47 µM 0.110393879911314 0.439070712201071 no 1450 0.456048503294087 2194 27241210 SGTC_671 0560-0003 407 µM 0.110281086314412 0.43911926118552 no 1451 0.456093228349062 2168 3238678 SGTC_2908 7930301 100 µM 0.108375628105986 0.439939552508465 no 1452 0.456848866602163 2214 2223178 SGTC_581 0958-0271 211 µM 0.108269977871264 0.439985042044937 no 1453 0.456890768390926 2152 4591145 SGTC_859 0439-0102 54.6 µM 0.106739903338019 0.440643930632093 no 1454 0.457497662570265 2240 610143 SGTC_1223 0764-0573 147 µM 0.106187624855502 0.440881796107604 no 1455 0.457716744683117 2186 1609797 SGTC_2009 4012297 12.05 µM 0.10557889683889 0.441143999018029 no 1456 0.457958234517962 2086 45595307 SGTC_638 3970-0837 4.09 µM 0.104629372496297 0.441553047673487 no 1457 0.458334953369475 2109 4118451 YLR208W SEC13 SGTC_1844 rapamycin 4 nM 0.0999277779803844 0.443579373049912 no 1458 0.460200831541142 2105 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_472 calcifediol 10 µM 0.0992047905419774 0.443891103398599 no 1459 0.460487835660981 2132 5283731 A vitamin D metabolite. SGTC_1780 st038448 24.544 µM 0.0989134990193986 0.444016709329022 no 1460 0.460603475400858 2176 728868 YDL195W SEC31 SGTC_911 3456-4043 236 µM 0.098545853213219 0.444175247521816 no 1461 0.460749431761632 2184 914281 SGTC_1353 1498-1206 8.11 µM 0.0983800554615573 0.444246746640095 no 1462 0.460815255640356 2208 6756808 SGTC_380 3970-0968 6 µM 0.0955503353215538 0.445467321476179 no 1463 0.461938855653608 2188 2891601 SGTC_162 k030-0015 37.8 µM 0.0953798426284735 0.445540878627739 no 1464 0.462006563164259 2211 1809920 YMR134W ERG29 SGTC_734 2023-0417 80 µM 0.0923656978870272 0.44684160466456 no 1465 0.463203746006333 2205 3935732 SGTC_2097 5376186 200 µM 0.0920439813974308 0.44698047244838 no 1466 0.463331547890753 2227 742755 SGTC_2021 4019055 173 µM 0.0916127267004372 0.447166632206703 no 1467 0.463502869765506 2209 44827708 YER133W GLC7 SGTC_2805 7950783 58.44 µM 0.0903902752148907 0.447694391095612 no 1468 0.463988542156694 2174 1178958 YDL195W SEC31 SGTC_2110 5483698 200 µM 0.0900634105383572 0.44783552141506 no 1469 0.464118412588212 2144 2848765 YHR062C RPP1 SGTC_2907 7721985 69.9 µM 0.0899467715505845 0.447885884215465 no 1470 0.464164756716318 2162 3267881 SGTC_1023 4482-3888 16 µM 0.0891695841289512 0.448221482396892 no 1471 0.464473568705165 2246 3303168 SGTC_2811 7967822 32.47 µM 0.0891580087162423 0.448226481069668 no 1472 0.464478168306485 2210 2232244 SGTC_1861 st057647 17.4 µM 0.0885524667059518 0.448487986979973 no 1473 0.464718792840083 2241 688668 SGTC_2345 9052315 157.45 µM 0.0880892967204188 0.448688024036229 no 1474 0.464902851644346 2150 6469265 SGTC_690 glyoxal 20.3 µM 0.0866908705835356 0.449292064935935 no 1475 0.465458616658146 2176 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_541 4513-1321 94 µM 0.0860526171192282 0.449567793436736 no 1476 0.46571229494951 2072 747515 SGTC_2659 sanguinarine 24.21 µM 0.0859161033254654 0.449626771204026 no 1477 0.46576655512132 2235 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2185 6113692 200 µM 0.085768419178775 0.449690576128437 no 1478 0.465825255892726 2178 874150 SGTC_229 benomyl 22.8748 µM 0.0851286833496003 0.449966980281029 no 1479 0.466079543527488 2161 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2862 9027634 71.43 µM 0.0821909191348437 0.451236579820871 no 1480 0.467247447247384 2226 5012562 SGTC_2696 st077691 74.316 µM 0.081220110184279 0.451656240024569 no 1481 0.467633453367984 2199 757133 SGTC_2985 9022375 71.43 µM 0.0803046981657693 0.452052002807014 no 1482 0.467997460844215 2175 4939335 SGTC_97 0535-0701 19.132 µM 0.0794790390683629 0.452409003327047 no 1483 0.468325801632132 2253 2832013 YGL099W LSG1 SGTC_2458 5808907 16.39 µM 0.0789277329936042 0.452647399851668 no 1484 0.468545052153791 2264 2731747 SGTC_1302 1159-0335 255 µM 0.078792848486735 0.452705729396546 no 1485 0.468598696222137 2218 649284 SGTC_1434 4073-0095 163 µM 0.0785002407310619 0.452832268393706 no 1486 0.468715069369748 2274 24133745 SGTC_3054 9094397 49.47 µM 0.0766764252006253 0.453621089717132 no 1487 0.469440479640302 2243 2598354 SGTC_2388 9080168 200 µM 0.0761346761021819 0.453855437866698 no 1488 0.469655976325349 2261 15943073 SGTC_2539 epi(13)torulosol 80 µM 0.0754766622755665 0.454140101054665 no 1489 0.469917732684267 2181 6708597 SGTC_874 0599-0792 117 µM 0.07362845489202 0.454939779111249 no 1490 0.470653014427362 2275 765305 SGTC_2282 7944268 200 µM 0.0732977662302573 0.455082880065831 no 1491 0.470784584605299 2224 2970414 SGTC_53 0973-0023 39.979 µM 0.0727225170334396 0.455331825094812 no 1492 0.471013464993624 2300 674768 SGTC_1579 chlormadinone acetate 49.4 µM 0.0723615155989523 0.455488061156987 no 1493 0.471157105288366 2288 45114258 A steroidal progestin. SGTC_2011 4012611 177 µM 0.0722555768038007 0.455533911202602 no 1494 0.471199258409355 2234 2049887 SGTC_1623 st003709 20.3 µM 0.0721983247416811 0.455558689998473 no 1495 0.471222039179418 2254 16192618 SGTC_2958 9077254 16.72 µM 0.0716197761236199 0.455809096569143 no 1496 0.471452250709402 2191 16457351 SGTC_3114 9122766 49.47 µM 0.0706401642454217 0.456233130731668 no 1497 0.471842071897235 2156 17176985 SGTC_35 0133-0054 64.071 µM 0.0695521639090339 0.456704140261269 no 1498 0.472275056175377 2229 99677 SGTC_2252 omeprazole 400 µM 0.0690897513759476 0.456904343136018 no 1499 0.472459089376416 2227 4594 A proton pump inhibitor. SGTC_2949 9072542 2.23 µM 0.0689447867224554 0.456967108266324 no 1500 0.472516784330447 2209 16457352 SGTC_3031 9088762 49.47 µM 0.0689096890182528 0.456982304628563 no 1501 0.472530753066672 2278 205253 SGTC_757 1066-0008 322 µM 0.0687584993073118 0.457047766427171 no 1502 0.472590926311274 2266 6842497 SGTC_2206 7254556 146.969 µM 0.0685051986744967 0.457157442606164 no 1503 0.472691740928176 2276 4398905 SGTC_455 paf C-16 10 µM 0.0684235956459837 0.457192776448011 no 1504 0.472724219617303 2270 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_514 4466-0038 2.65 nM 0.0679093362130923 0.457415456858806 no 1505 0.472928903344503 2168 5722064 SGTC_1976 st070609 63.5 µM 0.0676994202848684 0.457506356782592 no 1506 0.473012455400012 2278 682556 SGTC_64 000l-0018 272.079 µM 0.0658213215584233 0.45831972849735 no 1507 0.473760040447949 2234 6811119 SGTC_1265 0819-1001 68.8 µM 0.0655607754227363 0.458432580337316 no 1508 0.473863759285904 2293 3106768 SGTC_2264 7948757 110.76 µM 0.0654558250632831 0.458478039034733 no 1509 0.473905538680631 2293 2971411 SGTC_3040 9091894 49.47 µM 0.0653810424498427 0.45851043106266 no 1510 0.473935308856963 2242 25236966 SGTC_2432 5630864 12.22 µM 0.0638565661355541 0.459170816487149 no 1511 0.47454221842918 2229 5714970 SGTC_332 4112-0506 40.9 µM 0.0638378517432332 0.459178924048281 no 1512 0.474549669189656 2276 2790355 SGTC_2968 9090663 33.37 µM 0.0628313561599554 0.459614989017475 no 1513 0.474950398292734 2165 25236811 SGTC_3181 9108277 49.47 µM 0.0619767712040658 0.459985276754756 no 1514 0.475290665162999 2273 17097298 SGTC_3242 9133940 49.47 µM 0.061377143585645 0.460245113388351 no 1515 0.47552942740535 2280 17248444 SGTC_2619 obliquin 87.91 µM 0.0613332156345102 0.460264149356035 no 1516 0.47554691916784 2267 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2186 6124449 200 µM 0.0608067953604489 0.46049227813886 no 1517 0.475756539211565 2262 3834182 YLR033W RSC58 SGTC_2835 9006588 71.43 µM 0.0595203317028825 0.46104983287299 no 1518 0.476268835913491 2166 2345538 SGTC_2662 daunorubicin 22.37 µM 0.0592691444592521 0.461158706664464 no 1519 0.476368868525039 2282 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2816 7982706 58.44 µM 0.0591018433709167 0.461231222726184 no 1520 0.476435495206346 2242 2981853 SGTC_2368 9071271 200 µM 0.0588735605936007 0.461330173163166 no 1521 0.47652640855152 2243 27209959 SGTC_384 k007-0144 5.16 µM 0.0588669071917641 0.461333057153057 no 1522 0.476529058279254 2224 6824886 SGTC_2306 7482397 179.52 µM 0.0577088381887726 0.461835065692181 no 1523 0.476990276787163 2283 891448 SGTC_206 4546-0025 72.014 µM 0.0574614115226832 0.46194232999208 no 1524 0.477088822219164 2230 6620745 YIL048W NEO1 SGTC_3056 9094900 49.47 µM 0.0573036077088809 0.462010742478519 no 1525 0.47715167327073 2269 25236784 SGTC_3029 9088683 49.47 µM 0.0568155364335489 0.462222342502157 no 1526 0.477346068822654 2251 25236615 SGTC_2012 4023501 200 µM 0.0566872377526557 0.462277967310817 no 1527 0.477397170232986 2231 3477460 SGTC_1335 1486-0900 202 µM 0.056522544080267 0.462349372508976 no 1528 0.477462768326042 2313 X1335 SGTC_3185 9108267 49.47 µM 0.056036006128443 0.462560324782604 no 1529 0.477656561734552 2216 4910486 SGTC_2517 totarol 10 µM 0.0555517175798189 0.46277031222185 no 1530 0.477849464428139 2220 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_198 3454-2873 16.191 µM 0.0555319790687416 0.46277887105763 no 1531 0.477857326818071 2262 710957 SGTC_1407 3909-7909 12.3 µM 0.0545717542853013 0.46319525583196 no 1532 0.478239821014705 2298 4411780 SGTC_2340 7987427 183.45 µM 0.0538823931536761 0.463494210189138 no 1533 0.478514432256632 2295 2239331 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.0533793909875166 0.463712359512188 no 1534 0.478714812704027 2239 676296 Flavone; oxidizing agent. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0531089317241331 0.463829660748951 no 1535 0.478822557505634 2287 390807 SGTC_1769 st044406 64.4 µM 0.0527329447840172 0.463992735752666 no 1536 0.47897234469619 2249 670903 SGTC_1043 0916-0009 19.3 µM 0.0522156613695481 0.46421710447667 no 1537 0.47917842699426 2324 3101130 SGTC_2218 6965428 192.983 µM 0.0521647739870533 0.464239177203892 no 1538 0.479198700493195 2286 675684 SGTC_1359 1582-0056 520 nM 0.0521619682713124 0.46424039420422 no 1539 0.479199818290024 2273 3661189 SGTC_1773 st048542 73.5835 µM 0.051675941135894 0.464451217172608 no 1540 0.47939345390597 2273 3237138 SGTC_3096 9117468 49.47 µM 0.0486249890990048 0.465774847827664 no 1541 0.480609077547728 2320 41316311 SGTC_639 0833-0042 114 µM 0.048579220904719 0.465794706905132 no 1542 0.480627314863029 2277 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_333 3486-0131 40.1 µM 0.0485697126026886 0.465798832621662 no 1543 0.4806311036543 2315 6744690 SGTC_1325 1431-0015 227 µM 0.0481105558537433 0.465998068205456 no 1544 0.480814066796987 2299 1103340 SGTC_123 0083-0120 66.675 µM 0.0478009058682471 0.466132435186674 no 1545 0.48093745730244 2291 16001701 SGTC_1416 3966-0321 25.3 µM 0.0468549475201012 0.466542940459477 no 1546 0.481314417649578 2297 582530 YLR208W SEC13 SGTC_2062 5245942 200 µM 0.0466771217002688 0.466620113211328 no 1547 0.481385282352428 2328 1376160 SGTC_3224 9130643 49.47 µM 0.0446346552475866 0.467506590945792 no 1548 0.482199259641513 2293 17644395 SGTC_1313 1220-0047 237 µM 0.0445664372842954 0.467536201927429 no 1549 0.482226447616616 2274 3528706 SGTC_1134 3477-0009 42.5 µM 0.0431521293720126 0.46815014271154 no 1550 0.482790132370234 2336 3973534 SGTC_886 0866-0150 153 µM 0.0427374032980635 0.468330186715646 no 1551 0.482955431637602 2335 271463 SGTC_820 1582-0060 59.9 µM 0.0426717104000406 0.468358706406139 no 1552 0.482981615425838 2285 3848840 SGTC_175 3793-3120 23.7 µM 0.0411503506687002 0.469019229451595 no 1553 0.483588017271121 2300 5322297 SGTC_725 1497-0963 19 µM 0.039839461882842 0.469588441583597 no 1554 0.48411055757905 2328 3549977 SGTC_1605 st000082 49.1 µM 0.0386672789024832 0.470097477767467 no 1555 0.484577830771248 2302 1114022 SGTC_2610 ononetin 44.17 µM 0.0381048371188266 0.470341743058877 no 1556 0.48480204732483 2295 259632 SGTC_2092 5303694 80.6725 µM 0.0380965536852276 0.470345340590942 no 1557 0.484805349538999 2312 1963699 SGTC_3290 9121031 71.43 µM 0.0377543270582768 0.470493973249832 no 1558 0.484941780057344 2308 17014854 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.0377268250614489 0.470505917837875 no 1559 0.484952743955673 2349 23665772 A membrane-active detergent. SGTC_889 0919-1524 82.7 µM 0.0363246915130363 0.471114923369479 no 1560 0.48551173097425 2202 3905452 SGTC_1855 st056195 39.6 µM 0.0355202624254074 0.471464351320546 no 1561 0.485832444745048 2356 4028379 SGTC_540 1187-0821 17.3 µM 0.0352268973475803 0.471591788739827 no 1562 0.485949407277838 2332 847520 SGTC_976 1348-1067 47.6 µM 0.0347312654587379 0.471807097207795 no 1563 0.486147014864794 2356 5310671 YGL099W LSG1 SGTC_687 k029-0044 34.9 µM 0.0335245524354428 0.472331342219749 no 1564 0.486628143410704 2349 5829338 SGTC_778 3456-2434 196 µM 0.0335075029943615 0.472338749533059 no 1565 0.486634941334401 2328 5539063 SGTC_155 k072-0202 43.6 µM 0.0328555235207959 0.472622016191652 no 1566 0.48689490035925 2358 5857737 SGTC_2857 9024691 58.44 µM 0.0321441382554577 0.47293110878035 no 1567 0.487178552171652 2314 16478292 SGTC_2127 5253358 187.912 µM 0.0320917845365936 0.472953856800265 no 1568 0.487199427513743 2348 20612 SGTC_1149 3909-7961 23.3 µM 0.0319596714005319 0.473011261180259 no 1569 0.487252106007772 2252 735261 SGTC_2302 7771753 200 µM 0.0319504471311053 0.47301526923162 no 1570 0.487255784080485 2295 2203047 SGTC_3049 9092223 49.47 µM 0.030960489242802 0.473445433138748 no 1571 0.48765052478612 2318 8623917 SGTC_1673 st016611 27.3 µM 0.0307772032547786 0.473525079349744 no 1572 0.487723610486591 2315 5226799 SGTC_700 3453-2283 142 µM 0.0302606545181646 0.473749549271915 no 1573 0.487929587668795 2328 565664 SGTC_2391 6285546 200 µM 0.0299146586626042 0.473899908893954 no 1574 0.488067557579789 2351 846083 SGTC_2487 5918373 44.05 µM 0.0292319922766763 0.474196586511167 no 1575 0.488339782991564 2365 2876279 SGTC_1122 capsaicin 818.572 nM 0.028937726095677 0.474324475053725 no 1576 0.48845712856892 2315 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2676 harmalol 100 µM 0.0277339540368859 0.474847663682891 no 1577 0.48893717135354 2353 5459187 A monoamine oxidase inhibitor SGTC_2966 9084041 48.03 µM 0.0267589975987212 0.475271435310269 no 1578 0.489325978336686 2360 17741380 SGTC_1294 1000-1494 117 µM 0.0257164293235115 0.47572462583613 no 1579 0.489741759742794 2344 712797 YDL207W GLE1 SGTC_2827 7993847 71.43 µM 0.0253048570039402 0.475903539513513 no 1580 0.489905899922032 2328 2985692 SGTC_658 3253-0951 102 µM 0.0250925468017616 0.475995834305778 no 1581 0.489990572551331 2335 1184878 SGTC_979 1426-2828 121 µM 0.0248673309023987 0.476093740827826 no 1582 0.490080392667487 2329 747872 SGTC_776 4476-4378 112 µM 0.0231380614725054 0.476845541599998 no 1583 0.490770072570308 2248 2892008 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.0230149607269231 0.476899062886355 no 1584 0.490819169587994 2288 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_981 1488-1094 54.9 µM 0.0228223467690857 0.476982807705505 no 1585 0.490895991260947 2366 3449522 SGTC_1156 4092-0367 4.88 µM 0.0226864156924493 0.477041908517541 no 1586 0.490950205877648 2349 1357585 SGTC_2134 5324836 1.464 µM 0.02259336995892 0.477082363710926 no 1587 0.490987316242799 2343 699272 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0215434248525637 0.477538883796841 no 1588 0.491406081733816 2349 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_881 0833-0569 170 µM 0.0211566470109801 0.47770706371986 no 1589 0.491560348603704 2350 5418700 SGTC_1169 aniline yellow 25.8 µM 0.0200065308370239 0.478207184088464 no 1590 0.492019081377286 2356 6051 A DNA damaging agent. SGTC_1554 st069299 38.7 µM 0.0199026675004696 0.478252350070854 no 1591 0.49206050860491 2336 24207999 SGTC_507 nimesulide 162 µM 0.0168024153987381 0.479600650892849 no 1592 0.493297121480136 2377 4495 A COX2 inhibitor. SGTC_967 1306-0166 352 µM 0.0165886470203494 0.479693627621918 no 1593 0.493382390839474 2369 4437607 SGTC_1015 4130-4525 82 µM 0.0160731269881803 0.479917853189015 no 1594 0.493588026151346 2373 1363237 SGTC_2787 5284540 71.43 µM 0.0159794672679883 0.479958591191999 no 1595 0.493625386175564 2355 736958 SGTC_814 3342-0569 96 µM 0.0137071631946771 0.480947010156171 no 1596 0.494531804291015 2380 4346283 SGTC_2478 5763493 32.33 µM 0.0131489701715506 0.481189834096097 no 1597 0.49475447100992 2377 1365576 YLR208W SEC13 SGTC_771 0250-0039 27.3 µM 0.0130623620488361 0.481227510804886 no 1598 0.494789019684745 2377 3005115 SGTC_337 1315-0038 354 µM 0.0129734757097137 0.481266178769392 no 1599 0.494824477199007 2376 1626437 SGTC_3208 9114115 49.47 µM 0.0104559027009857 0.482361463023614 no 1600 0.495828774336786 2364 650895 SGTC_617 3770-0098 35 µM 0.0102997850630013 0.482429387346571 no 1601 0.495891052909451 2373 5962639 SGTC_1074 carmofur 3.8 µM 0.0101081669275044 0.482512758073259 no 1602 0.495967493505631 2385 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2331 7980721 200 µM 0.00968733191467615 0.482695860962016 no 1603 0.49613537416063 2370 2981221 SGTC_316 k060-0003 58.6 µM 0.0096585786535521 0.482708371473865 no 1604 0.496146844515561 2381 6152314 SGTC_398 bronopol 33.3 µM 0.00731050211919398 0.483730073305547 no 1605 0.497083557591165 2383 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3118 9124250 49.47 µM 0.00647118686545826 0.484095304847709 no 1606 0.497418387973045 2369 1504786 SGTC_66 0109-0187 42.4 µM 0.00539923370532952 0.484561789112424 no 1607 0.497846027858514 2393 759417 SGTC_3109 9122853 49.47 µM 0.00391627294297833 0.485207167180304 no 1608 0.498437637135165 2369 1234709 SGTC_1476 4112-3294 3.34 µM 0.00236740471015884 0.485881269238399 no 1609 0.499055543048514 2398 704369 SGTC_645 0845-0943 5.41 µM 0.00199003805555885 0.48604551382338 no 1610 0.499206090204043 2397 1885106 SGTC_3293 9120939 62.045 µM 0.00186589383523692 0.486099546715492 no 1611 0.49925561649032 2400 934087 SGTC_178 4092-0806 87.505 µM 0.00104505156887246 0.486456818870294 no 1612 0.499583084819865 2403 2169044 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.000701470405877398 0.486606366048974 no 1613 0.499720153819595 2403 66535 A nucleotide analog. SGTC_922 1866-0035 480 µM 0.000409050941472654 0.486733646065026 no 1614 0.499836812289159 2401 3156169 SGTC_2463 5473429 200 µM 0 0.486911693968502 no 1615 0.5 2405 5399405 SGTC_1377 2944-0135 198 µM -2.48574523604046e-05 0.486922513774476 no 1616 0.499990083311271 2406 1894137 SGTC_500 h-89 112 µM -0.000181579847626959 0.486990731200229 no 1617 0.499927560121911 2406 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2572 astragaloside iv 100 µM -0.000709633292169136 0.487220582740616 no 1618 0.499716897299934 2411 45006101 An anti-inflammatory agent. SGTC_2504 purpurogallin 52.29 µM -0.00082611654936117 0.487271286243383 no 1619 0.499670427217408 2409 5281571 An antioxidant. SGTC_693 4161-2696 114 µM -0.00174405951805402 0.487670860876909 no 1620 0.499304221271442 2413 805759 SGTC_1815 st051655 58.2 µM -0.00229186883521655 0.487909324649974 no 1621 0.499085677420936 2407 5984156 SGTC_3341 9147222 25.867 µM -0.00265846291570733 0.488068907063608 no 1622 0.498939427991297 2416 1939759 SGTC_172 1112-0046 2.638 µM -0.00414265587309768 0.488715011751968 no 1623 0.498347324146162 2412 2802135 YIL048W NEO1 SGTC_2199 6590217 200 µM -0.00511703971153022 0.48913920054873 no 1624 0.49795860541726 2423 703109 SGTC_3282 9108498 15.4605 µM -0.00636813260536863 0.489683869965455 no 1625 0.497459499827392 2426 16459645 SGTC_2347 9049783 174.81 µM -0.00637168135424501 0.489685414958495 no 1626 0.497458084110145 2419 6467988 YPL169C MEX67 SGTC_31 0508-1974 57.237 µM -0.00736459928025686 0.490117700424125 no 1627 0.497061976527337 2418 6810525 SGTC_1268 0828-0275 2.46 µM -0.00792582520146647 0.490362045836031 no 1628 0.496838086324652 2436 745337 SGTC_1378 2093-0007 380 nM -0.00867894411452744 0.490689942899562 no 1629 0.496537645709965 2431 3618014 SGTC_1150 3909-7983 10.9 µM -0.00892898581454438 0.490798808835273 no 1630 0.496437897370037 2430 23965914 SGTC_2927 9011802 47.9 µM -0.00923425374504736 0.490931720709732 no 1631 0.496316118108207 2436 43912568 SGTC_2267 7931562 200 µM -0.00924185988485394 0.490935032391508 no 1632 0.496313083826925 2419 934880 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.00929501590085092 0.490958176318199 no 1633 0.496291878555517 2425 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1660 st012960 28.1 µM -0.00940553416744378 0.491006295647438 no 1634 0.496247790073557 2428 24207266 SGTC_121 0557-0495 61.343 µM -0.0104138983078129 0.491445340395292 no 1635 0.49584553075288 2427 3104427 SGTC_1979 st071809 45.3 µM -0.0106473235087635 0.491546975919254 no 1636 0.495752412734368 2460 4976333 SGTC_1792 st045773 43.6 µM -0.0114949886848286 0.491916061861442 no 1637 0.4954142639903 2424 2919270 SGTC_2003 4023581 200 µM -0.0121245395399871 0.492190182102134 no 1638 0.495163127054372 2450 16641307 SGTC_3091 9116372 49.47 µM -0.0128688256425805 0.492514265331926 no 1639 0.494866223050405 2509 17169793 SGTC_3067 9117431 49.47 µM -0.0130470483458629 0.49259186928133 no 1640 0.494795128447764 2435 17150885 SGTC_1748 st037455 53.6035 µM -0.0131680034118581 0.492644537202679 no 1641 0.494746878502962 2441 580690 SGTC_1846 st056244 14.8 µM -0.0136688085065087 0.492862606011403 no 1642 0.494547104164409 2456 5393182 SGTC_2489 cantharidin 73.42 µM -0.0141290694209052 0.493063022287471 no 1643 0.494363504362068 2429 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2409 alverine citrate 63.97 µM -0.0149884746767929 0.493437246852365 no 1644 0.494020687613319 2570 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3231 9132313 49.47 µM -0.0158083316791293 0.493794255677166 no 1645 0.493693650774647 2451 4905967 SGTC_1 0258-0098 57.368 µM -0.0159499865114578 0.493855940147145 no 1646 0.493637145797104 2383 6790032 YDR047W HEM12 SGTC_1734 st037168 69.4 µM -0.0160174230823919 0.493885305869383 no 1647 0.49361024593411 2472 708907 SGTC_705 1124-0212 310 µM -0.0166634462234346 0.494166622780086 no 1648 0.493352554398891 2439 9554485 SGTC_411 enrofloxacin 100 µM -0.0172529658276798 0.494423337224311 no 1649 0.493117403921843 2443 71188 A bacterial gyrase inhibitor. SGTC_2719 novobiocin 32.65 µM -0.0172627029379278 0.494427577402975 no 1650 0.493113519955306 2437 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2951 9072950 58.06 µM -0.0180080470771959 0.494752151129856 no 1651 0.492816216906761 2433 16488155 SGTC_1393 3470-5649 58.2 µM -0.0184497422497357 0.494944497018055 no 1652 0.492640035303171 2459 4108395 SGTC_684 1140-0066 328 µM -0.018514150457818 0.494972545089668 no 1653 0.492614344533898 2444 6813534 SGTC_1665 st014639 11.4 µM -0.0185186648533739 0.494974510990501 no 1654 0.492612543859354 2445 981133 YIL048W NEO1 SGTC_1567 st069303 68.4 µM -0.0187061313519317 0.495056147839819 no 1655 0.492537768500042 2455 5581319 SGTC_665 3914-0008 307 µM -0.0197396766928868 0.495506233937775 no 1656 0.492125519757291 2454 1069549 SGTC_154 3389-1638 511.116 µM -0.0197489521342251 0.495510273213737 no 1657 0.492121820112773 2474 5238686 SGTC_520 3584-0023 682 µM -0.0201796410099926 0.495697830419638 no 1658 0.491950034349865 2495 1340790 SGTC_3197 9113331 49.47 µM -0.0204463833873334 0.495813992373955 no 1659 0.491843641489978 2457 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1788 fluconazole 20 µM -0.0206001181393968 0.495880941512667 no 1660 0.491782323112601 2495 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2603 homopterocarpin 100 µM -0.0215454805238454 0.496292634884951 no 1661 0.491405261829934 2458 101795 A weak amylase inhibitor. SGTC_1826 st055655 41.6 µM -0.0230290488418338 0.496938717932566 no 1662 0.490813550732535 2474 676168 SGTC_919 tnp00227 403.569 nM -0.0235309842288226 0.497157308989698 no 1663 0.490613361741217 2473 1269246 A methoxyflavone. YNL221C POP1 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.0246794334079927 0.497657457584254 no 1664 0.490155329923485 2464 4213774 SGTC_1527 coumarin 137 µM -0.0247537647777509 0.497689828964884 no 1665 0.490125685053895 2542 323 A hepatotoxic, DNA x-linker. SGTC_1712 st032288 53.4 µM -0.025076649778578 0.497830445856695 no 1666 0.489996912551017 2458 2883011 SGTC_2540 epiandrosterone 100 µM -0.0251190873866067 0.497848927517702 no 1667 0.489979987726235 2453 441302 A steroid. SGTC_3311 9131146 2.8755 µM -0.0255348792190237 0.498030005909144 no 1668 0.489814163978488 2488 4900406 YPR165W RHO1 SGTC_293 4049-0273 38.5 µM -0.026563579247642 0.498478009030958 no 1669 0.489403911275937 2454 1380311 SGTC_1041 0206-0046 107 µM -0.0266157415581543 0.498500725989058 no 1670 0.489383108879884 2524 50494 SGTC_1658 st012944 20 µM -0.0273343575238357 0.498813687450456 no 1671 0.489096526879105 2476 24207260 SGTC_1622 st003707 19.4 µM -0.0274629370990884 0.498869684691023 no 1672 0.489045250300091 2529 10140899 SGTC_1030 k029-0042 36.7 µM -0.0285127618046027 0.499326890906948 no 1673 0.488626594859914 2498 6080581 SGTC_856 0433-0016 11.3 µM -0.0289447367315464 0.499515019387941 no 1674 0.488454332900923 2490 3911780 SGTC_1361 1608-0041 5.61 µM -0.0290209399189994 0.499548206488296 no 1675 0.488423944993231 2459 X1361 SGTC_3330 9141424 71.43 µM -0.0291022909763157 0.499583635530779 no 1676 0.488391504319145 2465 27261020 SGTC_2179 6298986 200 µM -0.0291903874352188 0.499622002253827 no 1677 0.488356373841946 2487 738374 SGTC_609 0986-0026 86.3 µM -0.0299989436488037 0.499974135167071 no 1678 0.488033947819451 2453 2848610 SGTC_1217 1183-1422 255 µM -0.0301177236165289 0.499974135167071 no 1679 0.48798658287032 2490 2849664 SGTC_2838 9002687 71.43 µM -0.0303047808471512 0.499892670185416 no 1680 0.487911991880382 2461 6457060 SGTC_344 k064-0035 6.43 µM -0.0309149942715804 0.499626917206448 no 1681 0.487668665969746 2457 5088750 SGTC_2557 derrustone 83.84 µM -0.0310013586354477 0.499589304824356 no 1682 0.487634228080231 2512 629853 An antioxidant. SGTC_1621 st003705 32.4 µM -0.0324568364972934 0.498955433206103 no 1683 0.487053868681934 2449 24207032 SGTC_2488 5268135 45.7 µM -0.0325173222054597 0.498929091268682 no 1684 0.487029751105918 2493 1270356 YLR208W SEC13 SGTC_1180 1193-0155 285 µM -0.0327910053851713 0.49880990044196 no 1685 0.486920625509955 2500 2921347 SGTC_827 3253-0474 693 µM -0.0331132347323189 0.49866956757666 no 1686 0.486792144374008 2471 5402065 SGTC_1196 1588-0294 184 µM -0.0333339991428768 0.498573423410147 no 1687 0.486704120710859 2512 6144269 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.0334850407523527 0.498507643970647 no 1688 0.486643897446661 2471 688664 SGTC_3210 9128157 49.47 µM -0.0336137533547473 0.498451588966693 no 1689 0.486592577437636 2552 17590849 SGTC_3263 9137018 49.47 µM -0.0339514708156156 0.498304511414228 no 1690 0.486457924523554 2473 43844957 SGTC_3223 9129970 49.47 µM -0.0340309387554153 0.498269902783114 no 1691 0.486426239712075 2485 17248386 SGTC_1280 0880-0253 10.1 µM -0.0346775873956387 0.497988285013611 no 1692 0.486168416421822 2472 6836607 SGTC_245 methotrexate 289.6 µM -0.0347870032720366 0.49794063410784 no 1693 0.48612479212324 2488 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1422 4031-0024 15.5 µM -0.0349466945251338 0.497871088194449 no 1694 0.486061123243439 2465 782427 SGTC_1860 st056228 74.6 µM -0.0369458239759445 0.497000468814578 no 1695 0.485264101209982 2564 688679 SGTC_2148 5546263 113.568 µM -0.0370950858400814 0.496935465906258 no 1696 0.485204595132515 2486 792097 SGTC_580 1123-0028 41 µM -0.0392683127109655 0.495989044927673 no 1697 0.48433823495759 2472 1677248 YPR107C YTH1 SGTC_1928 4'-methoxychalcone 40.3 µM -0.0393191805740108 0.495966892675231 no 1698 0.484317957276708 2499 641818 SGTC_3083 9117465 49.47 µM -0.039691821739838 0.495804612973139 no 1699 0.484169410923344 2550 16420915 SGTC_2704 st078022 71.1 µM -0.0405496275743706 0.49543105393473 no 1700 0.483827471234292 2491 54697681 SGTC_445 e6 berbamine 66 µM -0.0409478112885106 0.495257653418496 no 1701 0.483668750745482 2521 6610268 A calcium/calmodulin antagonist. SGTC_3093 9117344 49.47 µM -0.0409770640551841 0.495244914497358 no 1702 0.483657090366741 2605 24824913 SGTC_2358 9037157 4 µM -0.0416333887213148 0.494959101184377 no 1703 0.483395477978949 2523 2388925 SGTC_495 decylubiquinone 155 µM -0.0416991689830006 0.494930455632187 no 1704 0.483369258221015 2527 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3302 9125395 16.351 µM -0.0421899234666153 0.494716745958725 no 1705 0.4831736476591 2508 17599668 SGTC_1888 azatryptophan 97.5 µM -0.0422796482045683 0.494677673539591 no 1706 0.483137884578456 2570 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1571 st070080 73.4 µM -0.0436323761040529 0.494088607710533 no 1707 0.482598721932657 2522 4315245 SGTC_2815 7968870 71.43 µM -0.0449214614953812 0.493527267950311 no 1708 0.482084955155343 2495 2977326 YHR190W ERG9 SGTC_1940 st075990 51.1 µM -0.0454299619092684 0.493305841939527 no 1709 0.481882299742503 2686 1084979 SGTC_465 cgp-37157 41 µM -0.0457728102692991 0.493156550114488 no 1710 0.481745665175333 2478 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_834 0312-0008 75.7 µM -0.0458602798894362 0.493118462002027 no 1711 0.481710806451774 2491 6385573 YIL048W NEO1 SGTC_2682 pyrogallin 40.03 µM -0.0464498038910848 0.492861759025685 no 1712 0.481475870779231 2496 822798 An ATP competetive kinase inhibitor. SGTC_2035 5154463 94.595 µM -0.0476904528068705 0.492321539288785 no 1713 0.480981471501516 2497 2769623 SGTC_2974 9094440 9.66 µM -0.0477174224787724 0.492309795950851 no 1714 0.480970724394477 2683 25236134 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.0478709802360192 0.492242932801431 no 1715 0.480909533641195 2532 5377381 SGTC_797 k781-0471 270 µM -0.0480909987369974 0.492147131249189 no 1716 0.480821859937088 2557 23738129 SGTC_1889 st059080 5.18 µM -0.0487201732793727 0.491873175452843 no 1717 0.480571149506533 2489 176925 Isolated from Daphnopsis sellowiana. SGTC_1784 st039334 36.3 µM -0.049059671271063 0.491725352488354 no 1718 0.480435871173626 2585 3496984 SGTC_1455 4262-0120 131 µM -0.0490696197230811 0.491721020787076 no 1719 0.480431907089811 2664 1529587 SGTC_3052 9092717 49.47 µM -0.0498215940815057 0.491393603033651 no 1720 0.480132279230762 2568 25237534 SGTC_444 curcumin 90.4 µM -0.0507727938421774 0.490979448723975 no 1721 0.479753285137803 2537 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_34 0469-0683 81.75 µM -0.0509127975793834 0.490918491622451 no 1722 0.47969750387128 2553 3690923 SGTC_2036 5160441 105 µM -0.0525593043012259 0.490201625075273 no 1723 0.479041521294393 2520 134534 YIL048W NEO1 SGTC_1951 sophoraflavanone G 9.2 µM -0.0529162802899216 0.490046206698613 no 1724 0.478899306387109 2493 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.0539182876036711 0.489609966039672 no 1725 0.478500133229093 2505 6312947 SGTC_2145 5634607 200 µM -0.0539243880206342 0.489607310158554 no 1726 0.478497703050293 2493 308662 SGTC_2598 perillyl alcohol 100 µM -0.0546130678652862 0.489307489086826 no 1727 0.478223363823119 2561 10819 An apoptosis inducer. SGTC_2081 5214970 32.255 µM -0.0550642356406371 0.489111073643061 no 1728 0.478043644359936 2500 2063512 SGTC_1932 st074806 40.9 µM -0.0555303740126388 0.488908143539072 no 1729 0.477857966156285 2703 17251235 SGTC_788 1182-0090 188 µM -0.0556413799619583 0.488859818291069 no 1730 0.477813749552545 2694 5715185 SGTC_2674 ligustilide 100 µM -0.0559328799607022 0.48873291767734 no 1731 0.477697638699694 2548 5319022 A signalling regulator. SGTC_1562 morin hydrate 59.1 µM -0.0560485507892515 0.48868256224935 no 1732 0.477651564991854 2600 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2597 laccaic acid a 100 µM -0.0562749183953065 0.488584017288931 no 1733 0.477561399692272 2548 5491415 A textile dye. SGTC_619 1652-1634 108 µM -0.0563895888426207 0.48853409789113 no 1734 0.477515725329822 2531 5400454 SGTC_3344 9148862 3.898 µM -0.0566329134363558 0.488428172178468 no 1735 0.477418807739581 2552 4905352 SGTC_2412 st077135 33.4 µM -0.056689542194744 0.488403520280057 no 1736 0.477396252369601 2770 13258915 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.056750878247598 0.488376819229985 no 1737 0.477371822154659 2570 6708739 YPR165W RHO1 SGTC_608 k048-0125 159 µM -0.0568565284245994 0.48833082730454 no 1738 0.477329741776486 2508 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3044 9093193 49.47 µM -0.0569914844425319 0.488272078105666 no 1739 0.477275989273826 2568 25236277 SGTC_3030 9087619 49.47 µM -0.0571576587406167 0.488199739281225 no 1740 0.477209803209093 2519 25236973 SGTC_3346 9158254 43.5805 µM -0.0578019713416796 0.487919261475037 no 1741 0.476953183951435 2560 17639500 SGTC_2136 5328288 199.296 µM -0.0614195519546465 0.48634459564473 no 1742 0.475512540773181 2525 262395 SGTC_3179 9107801 49.47 µM -0.0620555258302734 0.486067789302992 no 1743 0.475259306972695 2532 4818259 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.0627386672397328 0.485770460869219 no 1744 0.474987303011772 2519 688669 SGTC_1746 st038117 42 µM -0.0627763728181149 0.485754050234351 no 1745 0.474972290255396 2581 2898218 SGTC_2343 7990716 14.84 µM -0.0632776628309725 0.48553587560697 no 1746 0.47477270129465 2526 6456862 SGTC_485 niflumic acid 177 µM -0.0633025672920529 0.485525036641392 no 1747 0.474762785731137 2609 4488 A COX2 inhibitor. SGTC_1692 fluoroquinolonic acid 71 µM -0.0633898789747058 0.485487036774024 no 1748 0.474728023225897 2622 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2396 5342950 42.78 µM -0.0645987328796037 0.484960932009153 no 1749 0.474246746810009 2572 1886677 SGTC_1451 4152-0210 104 µM -0.0649463827139866 0.484809636287431 no 1750 0.474108345228555 2501 659563 SGTC_1740 st038286 13.222 µM -0.0649934820342511 0.484789139032323 no 1751 0.474089594933476 2585 716786 SGTC_804 1595-0054 20.9 µM -0.0650367090620752 0.484770327003913 no 1752 0.474072386253108 2528 761523 Stimulates phospholipase C. SGTC_784 4579-0127 173 µM -0.0658941356450962 0.484397189434149 no 1753 0.473731054757335 2711 1948547 SGTC_323 4013-0906 34.3 µM -0.0668981104499314 0.483960293942094 no 1754 0.473331408656508 2622 2910086 SGTC_2947 9072639 7.68 µM -0.0680376007386537 0.483464450106523 no 1755 0.472877851278842 2577 16488146 SGTC_4 0960-0234 25.671 µM -0.0682243349055969 0.483383196031047 no 1756 0.47280352782327 2550 6821112 SGTC_764 1951-2361 146 µM -0.0684250034976875 0.483295879405884 no 1757 0.47272365927899 2535 5438930 SGTC_642 0335-0876 158 µM -0.0684755796228133 0.483273872418234 no 1758 0.472703529537954 2537 6812350 SGTC_3065 9113888 49.47 µM -0.0686492423502056 0.483198307636453 no 1759 0.472634410781494 2615 16648368 SGTC_2700 st077718 96.8 µM -0.0718751536485403 0.48179474954466 no 1760 0.471350631706415 2587 904970 SGTC_1005 4092-0690 4.4 µM -0.0725574704727378 0.481497909412781 no 1761 0.471079135558473 2562 1529343 SGTC_1136 pergolide 1.05886 µM -0.073436817917685 0.48111536678182 no 1762 0.470729260107852 2563 47811 A dopamine receptor agonist. SGTC_199 4063-0024 41.6 µM -0.0735485341163138 0.481066768107304 no 1763 0.47068481199106 2629 306215 SGTC_2257 7960413 200 µM -0.0736328678461887 0.481030081514658 no 1764 0.470651258679191 2579 2974689 YIL048W NEO1 SGTC_393 acivicin 6.25 µM -0.0745459769608808 0.480632874025459 no 1765 0.470287979293165 2555 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2911 7942208 15.64 µM -0.0759770545112722 0.480010386249563 no 1766 0.4697186766349 2599 1243384 SGTC_118 0083-0097 135.343 µM -0.0759944003194147 0.480002841494204 no 1767 0.469711776607221 2566 5207356 SGTC_493 zm226600 134 µM -0.0761167838239259 0.479949609609023 no 1768 0.469663093658806 2673 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1433 4060-0023 7.6 µM -0.0765711857123752 0.4797519662629 no 1769 0.469482341052641 2622 3840627 SGTC_2779 methotrexate 400 µM -0.0771612009668102 0.47949534494726 no 1770 0.469247653365802 2520 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1583 clindamycin 39.6 µM -0.0776023497926538 0.479303477163613 no 1771 0.469072186578081 2556 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_46 0329-0187a 2.197 µM -0.0788125321849923 0.478777160240262 no 1772 0.468590867906829 2582 46494817 SGTC_1912 st060209 90.8 µM -0.0792456701456267 0.47858879440776 no 1773 0.468418609631265 2605 688787 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.0797414646019045 0.478373185986622 no 1774 0.468221440226642 2580 279621 SGTC_137 0438-0332 85.389 µM -0.0802856623491756 0.478136535491636 no 1775 0.468005030594635 2539 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_899 1083-0020 478 µM -0.0804915074031669 0.478047023465663 no 1776 0.467923175215307 2711 767123 SGTC_721 1187-1332 279 µM -0.0805955567409195 0.478001777878428 no 1777 0.467881799959175 2526 25730 SGTC_454 lyso-paf C-16 6.67 µM -0.0808857517677605 0.477875588816422 no 1778 0.467766405638342 2600 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1539 benzyladenosine 56 µM -0.081347903451344 0.477674630316919 no 1779 0.467582639374526 2555 92208 A nucleotide analog. SGTC_2929 9013348 24.6 µM -0.0821194084866144 0.477339167647928 no 1780 0.467275879754177 2624 2995952 SGTC_2570 licareol 100 µM -0.0828028828873986 0.477041995505543 no 1781 0.467004138394734 2664 443158 SGTC_2165 5727197 32.143 µM -0.0828379502668563 0.477026748681519 no 1782 0.466990196431998 2920 1361712 SGTC_2950 9072895 21.46 µM -0.0841184329752437 0.476470035269913 no 1783 0.466481134594965 2607 17332245 SGTC_1913 st060213 96.1 µM -0.0841498195483375 0.476456389952113 no 1784 0.466468657402385 2605 688959 SGTC_2299 7976368 114.88 µM -0.0842228522368828 0.476424639085677 no 1785 0.466439624640102 2612 2979718 SGTC_2247 cerulenin 830 nM -0.0843700442536534 0.4763606480027 no 1786 0.466381111784075 2755 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_421 streptovitacin 30 mM -0.0843881013007984 0.476352797822689 no 1787 0.46637393366354 2747 91467 include heat shock SGTC_753 1322-0200 289 µM -0.084661886949298 0.476233772476506 no 1788 0.466265098473297 2661 5403907 SGTC_2026 5148700 152 µM -0.0847142139552619 0.476211024118295 no 1789 0.466244297744218 2566 79838 SGTC_1503 4585-0012 61.3 µM -0.0851055191066541 0.47604091270609 no 1790 0.466088751308085 2732 2922052 SGTC_597 k018-0003 82.8 µM -0.0852865420612911 0.475962218385295 no 1791 0.466016795214042 2641 6786234 SGTC_2437 5741531 144.16 µM -0.086033869848959 0.47563734991768 no 1792 0.465719746393987 2631 2262990 SGTC_749 1000-0129 128 µM -0.0862670284969611 0.475535997573413 no 1793 0.465627074092631 2643 708470 SGTC_1496 4469-0713 57.4 µM -0.0865467726849881 0.475414396928054 no 1794 0.465515888149992 2547 746691 SGTC_1883 5-benzylidenerhodanine 20 µM -0.088162383973499 0.474712159840979 no 1795 0.464873807050731 2612 1273210 SGTC_817 1391-0715 46 µM -0.0903825017657385 0.473747298232351 no 1796 0.463991630672301 2628 1353946 SGTC_2109 5483026 200 µM -0.090662096693015 0.473625797276984 no 1797 0.46388054450439 2607 759335 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0906805321407517 0.473617786042794 no 1798 0.463873219995244 2600 6857784 SGTC_1121 fusaric acid 630.51 nM -0.0914273197253915 0.473293274032778 no 1799 0.463576527325269 2605 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1870 st057514 26.5 µM -0.0926004209601658 0.472783545884376 no 1800 0.463110504654408 2552 5393161 SGTC_2954 9074818 52.69 µM -0.0932483797602561 0.472502018187766 no 1801 0.462853120150342 2648 16648742 SGTC_923 1900-2434 73.3 µM -0.0934811372170884 0.472400892155511 no 1802 0.462760667194553 2560 5910570 SGTC_1970 st070122 35.8 µM -0.0935391775670317 0.472375675666475 no 1803 0.462737613458311 2680 102928 SGTC_2196 6573537 42.6665 µM -0.0948125131872901 0.471822484197797 no 1804 0.462231873781672 2650 2903087 SGTC_1054 3429-0080 167 µM -0.0957467578545835 0.47141664285584 no 1805 0.461860852031523 2621 1162877 SGTC_1193 1488-0126 41.5 µM -0.096143502000876 0.471244303834629 no 1806 0.461703300855681 2606 1384710 SGTC_843 0310-0051 143 µM -0.0964673026189484 0.471103654251288 no 1807 0.461574720756861 2586 2065037 SGTC_2055 5235184 200 µM -0.0973852887038754 0.470704927411362 no 1808 0.4612102135544 2675 2836034 SGTC_48 0382-0018 55 µM -0.09922299449688 0.469906809371904 no 1809 0.460480608988869 2625 762596 SGTC_1635 st007035 42.4 µM -0.100405180861833 0.469393447974651 no 1810 0.46001132841045 2572 3716403 SGTC_806 3966-4455 5.86 µM -0.10126142527849 0.469021657752301 no 1811 0.459671468458094 2615 714982 SGTC_876 0720-0963 56.8 µM -0.101367528403819 0.468975588547264 no 1812 0.459629356124539 2705 765861 SGTC_2079 5212404 121 µM -0.101430135283309 0.468948405290525 no 1813 0.459604507664678 2598 758462 SGTC_3085 9117376 49.47 µM -0.101456327778436 0.468937032824159 no 1814 0.459594111998285 2665 16480349 SGTC_285 1486-1325 46 µM -0.101498452113082 0.468918742997848 no 1815 0.459577393124798 2665 22310230 SGTC_2228 7354201 200 µM -0.10345868114493 0.468067710792139 no 1816 0.458799470567525 2608 753451 SGTC_607 4491-0986 66.8 µM -0.103796866179639 0.467920902621177 no 1817 0.458665276731797 2649 698981 YDR232W HEM1 SGTC_3123 9126162 49.47 µM -0.104064245460567 0.467804834743878 no 1818 0.458559182374445 2603 25239884 SGTC_3340 9146634 11.102 µM -0.104130260728795 0.467776178299443 no 1819 0.458532988400044 2642 4907387 SGTC_3247 9135149 49.47 µM -0.105327661495973 0.467256429968397 no 1820 0.458057907175119 2565 8934436 YOR116C RPO31 SGTC_1184 1269-1718 139 µM -0.107300955523852 0.466400016670493 no 1821 0.457275113260996 2709 5403821 SGTC_1051 3253-3903 78 µM -0.108016836708595 0.46608936114193 no 1822 0.456991168295242 2569 5509239 SGTC_3250 9135583 49.47 µM -0.109789056722152 0.465320398299662 no 1823 0.45628833502399 2737 7699353 SGTC_1767 st044992 70.3 µM -0.110360063755409 0.465072666891727 no 1824 0.456061912059151 2632 9600693 SGTC_2461 5755302 26.15 µM -0.111138427446232 0.464734995616798 no 1825 0.455753288392295 2758 2788904 SGTC_1018 4259-0013 28.1 µM -0.11349096269817 0.463714569482671 no 1826 0.454820663756785 2759 6801262 SGTC_1616 st002734 56.1 µM -0.113502554843045 0.463709541906412 no 1827 0.454816068850262 2628 4026101 SGTC_1452 4194-0072 190 µM -0.114365749993987 0.463335185814581 no 1828 0.454473931680783 2766 1343545 SGTC_853 0419-0306 21 µM -0.115015611684693 0.463053370969618 no 1829 0.454216373914503 2604 762713 SGTC_2795 7780010 54.55 µM -0.11506516661828 0.463031882054611 no 1830 0.454196734742471 2719 953673 SGTC_2889 9059656 51.95 µM -0.115560212713789 0.462817217060779 no 1831 0.454000548616879 2698 3949838 SGTC_2750 bromebric acid 70.15 µM -0.115860510835014 0.462687005177742 no 1832 0.453881546326737 2714 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2800 7887935 81.82 µM -0.115878042600534 0.462679403374779 no 1833 0.453874598957713 2726 2961002 SGTC_1909 st060837 51.5 µM -0.115919625574844 0.462661372981817 no 1834 0.453858120795386 2662 678937 SGTC_2917 7979103 53.79 µM -0.116007052627562 0.462623464829837 no 1835 0.453823476174199 2714 2980565 SGTC_1959 st077091 55.8 µM -0.117868157474152 0.461816575487419 no 1836 0.453086061993263 2593 821356 YKL052C ASK1 SGTC_3130 9127414 49.47 µM -0.118521285701092 0.461533446247821 no 1837 0.452827315205755 2592 1494646 SGTC_1106 tegaserod maleate 11.7 µM -0.118530765047207 0.461529337121258 no 1838 0.45282355996426 2666 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_288 1315-0019 35.1 µM -0.118650503476183 0.461477433013095 no 1839 0.452776125967537 2664 6811474 SGTC_2335 9018011 154.17 µM -0.119792830926008 0.460982291036955 no 1840 0.452323630569504 2728 6458208 SGTC_3353 9151644 39.2805 µM -0.120225514195518 0.460794760171523 no 1841 0.452152253478438 2713 4909158 SGTC_1148 3909-7663 27.7 µM -0.120254343948111 0.460782265270565 no 1842 0.452140834913016 2772 4084526 SGTC_2842 9000675 19.48 µM -0.121461679647015 0.46025903728308 no 1843 0.451662682572107 2699 2989072 SGTC_416 estradiol valerate 100 µM -0.121629380958981 0.460186365304686 no 1844 0.451596271798279 2681 13791 A steroid. SGTC_977 1348-1378 135 µM -0.122948062354278 0.459614972150518 no 1845 0.451074113026021 2618 X977 SGTC_311 1315-0136 58 µM -0.123387697624255 0.459424493832513 no 1846 0.450900049252453 2759 6759207 SGTC_1683 st010134 710 nM -0.124268531812257 0.459042887790879 no 1847 0.450551331056932 2614 3818134 SGTC_2440 5628896 157.78 µM -0.124301123265923 0.459028768834105 no 1848 0.450538428981249 2642 5522048 SGTC_1479 0549-0158 134 µM -0.125011512408056 0.458721033738006 no 1849 0.45025721812819 2676 5440202 SGTC_44 0929-0055 61.211 µM -0.125797181478371 0.45838071677267 no 1850 0.449946236452448 2639 1379590 SGTC_1596 piperlongumine 63 µM -0.126341399955373 0.45814500335461 no 1851 0.449730843186766 2783 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1310 1188-0297 994 nM -0.127520727366428 0.457634260407658 no 1852 0.449264134518348 2675 1588352 SGTC_150 3970-0969 77.2 µM -0.127645027565846 0.457580432555635 no 1853 0.449214947862028 2755 6615640 SGTC_2846 9008642 19.48 µM -0.128221069456236 0.457330989407923 no 1854 0.448987013339648 2765 2992898 SGTC_422 cantharidin 155 µM -0.128478934419745 0.457219331705064 no 1855 0.448884983975748 2614 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1144 3486-0183 12.5 µM -0.128505719120549 0.457207733897291 no 1856 0.448874386273731 2656 6744069 SGTC_282 k297-0036 65.7 µM -0.129190651216376 0.456911169882437 no 1857 0.448603396733465 2762 5061378 SGTC_3350 9150499 3.57 µM -0.129607321696492 0.456730770339193 no 1858 0.448438555118317 2637 4910996 YPR165W RHO1 SGTC_382 3229-0966 23.2 µM -0.129674433509856 0.456701714780813 no 1859 0.448412005425634 2771 5722370 SGTC_51 1013-0126 23.419 µM -0.130175599178499 0.456484746176815 no 1860 0.448213749663728 2672 1627850 SGTC_3103 9120822 49.47 µM -0.130267776177008 0.456444841592355 no 1861 0.448177286838742 2837 17141819 SGTC_3200 9114385 49.47 µM -0.130806563448404 0.456211602592176 no 1862 0.447964165365764 2764 17018030 YLR208W SEC13 SGTC_2120 5538279 151.968 µM -0.131439657463456 0.455937557840133 no 1863 0.447713759328494 2661 2058197 SGTC_1625 st003711 30.1 µM -0.13150720928864 0.455908318200083 no 1864 0.447687041958417 2774 24207034 YER133W GLC7 SGTC_1818 st052136 56.3 µM -0.131630016429465 0.455855162045437 no 1865 0.44763847120927 2673 674169 SGTC_1160 4092-0570 10.5 µM -0.131806290710343 0.45577886441946 no 1866 0.447568755350171 2625 4994975 SGTC_374 0880-0231 82.3 µM -0.132052898748128 0.455672126639947 no 1867 0.4474712254558 2717 6833587 SGTC_1034 k072-0165 12.7 µM -0.132537765161622 0.455462274348145 no 1868 0.447279477103616 2758 5835461 SGTC_2050 5263056 171 µM -0.134458179807805 0.454631233175563 no 1869 0.446520139207087 2718 763468 YGL055W OLE1 SGTC_1910 st062352 60.4 µM -0.135718590534507 0.454085910109333 no 1870 0.446021875292158 2616 2245730 SGTC_1362 1611-0397 101 µM -0.137385617622371 0.453364795509694 no 1871 0.445362999362148 2664 27816 SGTC_692 k241-0027 77.8 µM -0.137790364255151 0.4531897352536 no 1872 0.445203049963664 2782 3600480 SGTC_710 3448-4187 58 µM -0.138062270425828 0.453072136011657 no 1873 0.445095601999584 2667 3946412 SGTC_1252 0493-0875 34.8 µM -0.138883057426429 0.452717171172062 no 1874 0.444771279711807 2640 3960963 SGTC_3213 9129884 49.47 µM -0.139269908311476 0.452549883284022 no 1875 0.444618433901808 2745 17190742 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.139282217244687 0.452544560607777 no 1876 0.444613570744727 2642 97141 SGTC_430 0958-0115 16.4 µM -0.141334945039359 0.451657032188051 no 1877 0.443802672266839 2692 6833180 SGTC_2214 7179297 48.276 µM -0.141839578946168 0.451438882783349 no 1878 0.443603360312034 2653 769744 SGTC_223 busulfan 5 mM -0.14200898624034 0.451365652581371 no 1879 0.443536453816555 2760 2478 A DNA alkylator. SGTC_1244 0416-0015 52.5 µM -0.142416953708973 0.451189306050172 no 1880 0.443375335878217 2681 96201 SGTC_1383 3049-0032 20.7 µM -0.142604074781712 0.451108424997559 no 1881 0.443301439582789 2798 712864 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.142729667135529 0.451054140204056 no 1882 0.443251842802254 2709 4330530 SGTC_1087 pterostilbene 9.05 µM -0.14314950255259 0.450872681357456 no 1883 0.443086055050313 2774 5281727 Similar to reservatol, lowers cholesterol. SGTC_1467 k284-1082 293 µM -0.143356129010124 0.450783378227356 no 1884 0.443004464504872 2726 3334705 SGTC_558 k064-0027 21.3 µM -0.146514236551608 0.449418769444402 no 1885 0.441757726025001 2766 5088526 SGTC_2623 humulene 100 µM -0.147200768219699 0.449122199745642 no 1886 0.441486777126008 2718 6187145 An anti-inflammatory. SGTC_1130 3454-2858 15.9 µM -0.147938850026094 0.448803392994664 no 1887 0.441195513820629 2786 715628 YIL048W NEO1 SGTC_2553 4-methylesculetin 85.09 µM -0.148717347689983 0.448467164857431 no 1888 0.440888335993877 2674 5319502 SGTC_1933 st074711 15.9 µM -0.149468413518297 0.448142819429576 no 1889 0.440592015860246 2634 17250958 SGTC_1397 3532-0190 20.1 µM -0.150867434808511 0.447538749048283 no 1890 0.440040144830578 2639 5322280 SGTC_47 0149-0135 24.25 µM -0.151831754487701 0.447122445174797 no 1891 0.439659818010436 2639 5239155 SGTC_1763 st044482 94.5 µM -0.152269760388877 0.446933374028697 no 1892 0.439487087242796 2800 88505 SGTC_2783 7738165 71.43 µM -0.15245820867854 0.44685203149485 no 1893 0.439412774851079 2736 17201110 SGTC_160 3453-0671 289.699 µM -0.153867785038656 0.446243667756255 no 1894 0.43885699269128 2707 5322268 SGTC_2301 7769476 200 µM -0.154107493691586 0.44614022365092 no 1895 0.43876248987767 2760 977820 SGTC_1418 3966-3099 2.4 µM -0.154181912843182 0.446108109483164 no 1896 0.438733151558167 2719 740335 SGTC_2706 st078239 82.5 µM -0.154193278097605 0.44610320505515 no 1897 0.43872867105478 2677 15434492 SGTC_1238 0333-0287 48.8 µM -0.156606367158675 0.445062076947395 no 1898 0.437777542101044 2689 7226 SGTC_2023 5144124 124 µM -0.158732676370028 0.44414499383225 no 1899 0.436939746267712 2720 2830192 SGTC_3146 9095609 49.47 µM -0.15970277740758 0.443726685564057 no 1900 0.436557606465972 2762 17173999 SGTC_2434 5670830 169.91 µM -0.159811358076558 0.443679869393808 no 1901 0.436514838314736 2778 1549830 SGTC_3110 9122132 49.47 µM -0.159887980507187 0.443646832966318 no 1902 0.436484658437968 2833 918317 SGTC_2006 4011487 200 µM -0.159902599507641 0.443640529901587 no 1903 0.436478900379775 2816 45595294 SGTC_1340 1486-1359 257 µM -0.161158292744095 0.443099184036571 no 1904 0.43598436461705 2733 4309068 SGTC_100 0086-0128 49.5915 µM -0.162172983507162 0.442661815036086 no 1905 0.435584817094234 2732 93297 SGTC_3116 9124943 49.47 µM -0.162743937541918 0.442415743552646 no 1906 0.435360025486599 2701 41905195 YPL160W CDC60 SGTC_2397 5161689 200 µM -0.163852405437822 0.441938076245315 no 1907 0.434923667778915 2867 2259942 SGTC_2821 7996764 71.43 µM -0.164174286105403 0.441799385377423 no 1908 0.434796971571527 2863 2987135 SGTC_3043 9092303 49.47 µM -0.165075557231009 0.441411086693743 no 1909 0.434442255780522 2722 25236084 SGTC_1036 k216-0215 33.5 µM -0.16520014350717 0.441357415050606 no 1910 0.434393226157423 2685 622330 SGTC_341 1486-1430 230 µM -0.165456721885878 0.441246884735438 no 1911 0.434292255605749 2682 2054753 YPL210C SRP72 SGTC_2351 9026858 72.31 µM -0.165582540924843 0.441192685355101 no 1912 0.434242743967014 2698 1409300 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.166675639286032 0.440721855111885 no 1913 0.43381263720692 2672 6708784 An antioxidant flavonoid SGTC_1385 3091-4834 14.1 µM -0.166887117659813 0.440630774687055 no 1914 0.433729434807008 2810 4072814 SGTC_3147 9097027 49.47 µM -0.167015497251057 0.440575485138647 no 1915 0.433678927575282 2735 25236841 SGTC_1077 5-fluorocytosine 377 nM -0.167071253343356 0.440551472888573 no 1916 0.433656992292961 2782 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2902 5787006 60.46 µM -0.167243582025877 0.44047725817634 no 1917 0.433589196898616 2715 591003 SGTC_1475 4092-1048 11.7 µM -0.167364095709933 0.440425359245855 no 1918 0.433541787073599 2764 2881759 SGTC_929 2805-0021 398 µM -0.167639314887502 0.440306840602474 no 1919 0.433433520025504 2802 3098024 SGTC_2628 lathosterol 100 µM -0.16816487181298 0.440080532962757 no 1920 0.433226787789529 2851 6710616 SGTC_95 0471-0001 561.058 µM -0.168312281365652 0.44001706112824 no 1921 0.433168806280953 2714 4015405 SGTC_3165 9101544 49.47 µM -0.168626986952772 0.439881559867498 no 1922 0.433045026006734 2813 5002184 SGTC_1881 5652484 16 µM -0.169976677299538 0.439300510284192 no 1923 0.432514239272436 2800 2255129 SGTC_3309 9129340 25.759 µM -0.170475474099357 0.439085808370172 no 1924 0.432318110431236 2764 17158987 SGTC_2398 5228213 48.84 µM -0.170756045159145 0.438965047335593 no 1925 0.43220779612505 2817 80771 YMR134W ERG29 SGTC_982 1491-0518 27.5 µM -0.171087847826989 0.438822242955872 no 1926 0.432077345510223 2740 3091256 SGTC_1406 3909-7906 11.9 µM -0.172363095688192 0.438273463963973 no 1927 0.431576041651412 2744 X1406 SGTC_1757 st041620 31.8375 µM -0.172984513924636 0.438006091222627 no 1928 0.431331800106539 2779 5289815 SGTC_3045 9092950 49.47 µM -0.174736389684654 0.437252478139763 no 1929 0.430643386403218 2748 44120432 SGTC_2286 7945697 125 µM -0.174953632447658 0.43715904154988 no 1930 0.430558033750631 2789 1245733 SGTC_270 tamoxifen 5.46 µM -0.175228437893178 0.437040852145407 no 1931 0.430450069905378 2888 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_691 1548-0686 185 µM -0.175809813762425 0.43679083026032 no 1932 0.43022167973178 2742 46495133 SGTC_2311 7694451 200 µM -0.176367206936688 0.436551145886803 no 1933 0.430002732939688 2794 2163142 SGTC_2104 5389443 200 µM -0.176685122604431 0.436414449547741 no 1934 0.429877863729488 2881 2244536 SGTC_237 nikkomycin 200 µM -0.177010729821705 0.436274453892812 no 1935 0.429749980744251 2855 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_685 1278-0033 54.9 µM -0.177354744209871 0.436126552700372 no 1936 0.429614876307701 2825 3590572 SGTC_2370 9071495 200 µM -0.177748754711494 0.435957167785089 no 1937 0.429460147073772 2777 21791103 SGTC_305 1682-2595 20.8 µM -0.178120996706304 0.435797151929921 no 1938 0.429313976359034 2765 226033 SGTC_1308 1187-1617 41.4 µM -0.179099630781946 0.435376516205716 no 1939 0.428929735956437 2694 2882570 SGTC_2932 9016711 44.54 µM -0.179402838297683 0.435246206603813 no 1940 0.428810701452271 2796 7117328 SGTC_2069 5228469 200 µM -0.179516818327885 0.435197223183453 no 1941 0.428765956358126 2858 2835210 SGTC_2157 5649910 96.377 µM -0.180270855233048 0.434873197584313 no 1942 0.428469967485758 2745 2858091 SGTC_1192 1488-0095 21.4 µM -0.181030966274264 0.434546606065183 no 1943 0.428171634997425 2796 915875 SGTC_78 0336-0123 156.75 µM -0.181054444096188 0.43453651922588 no 1944 0.428162420947693 2678 6765896 SGTC_45 0kpi-0036 14.9 µM -0.182694100309529 0.433832175126779 no 1945 0.427519022561941 2851 2795021 SGTC_3254 9136651 49.47 µM -0.182841440814292 0.433768892590169 no 1946 0.427461215803087 2726 16454030 SGTC_963 1269-2853 151 µM -0.183103666112189 0.433656271399073 no 1947 0.427358339632646 2763 3668223 SGTC_1194 1488-0194 225 µM -0.183377553864698 0.433538647138091 no 1948 0.427250893324544 2700 1391452 SGTC_1834 st055981 52.8 µM -0.183445033022392 0.433509668337224 no 1949 0.427224422044043 2889 471719 YDL150W RPC53 SGTC_1232 0279-0259 161 µM -0.18546839726119 0.432640904999159 no 1950 0.426430832776647 2750 1560000 SGTC_841 0251-0215 91.2 µM -0.188433249395287 0.431368488058653 no 1951 0.425268518633412 2788 3888614 SGTC_496 calpeptin 138 µM -0.191333599836223 0.430124441789845 no 1952 0.424132119233595 2812 73364 A calpain inhibitor. SGTC_2897 9048598 12.99 µM -0.191338400663758 0.430122383144014 no 1953 0.424130238719789 2766 6467404 SGTC_2807 7945238 51.95 µM -0.193447207155819 0.429218288973507 no 1954 0.423304373807484 2861 17148797 SGTC_2263 7948595 193.29 µM -0.194654830331103 0.428700719789748 no 1955 0.422831587786966 2737 2971371 SGTC_3002 9075603 71.4286 µM -0.195068519514879 0.42852344695494 no 1956 0.422669653461967 2766 20105405 SGTC_2718 lomofungin 53.02 µM -0.195190674817226 0.428471104091308 no 1957 0.422621839538089 2901 5351222 A RNA synthesis inhibitor. SGTC_2029 5175081 200 µM -0.195270178055215 0.428437038074524 no 1958 0.422590721061134 2750 1380876 SGTC_2543 pimpinellin 60.67 µM -0.195764787925367 0.428225116704802 no 1959 0.422397135958121 2764 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_591 4299-0174 154 µM -0.19611043598441 0.428077032043759 no 1960 0.422261864065138 2787 5509088 SGTC_2138 5575593 77.673 µM -0.196207172476105 0.428035589415907 no 1961 0.422224007173928 2752 762213 SGTC_1468 k284-1086 134 µM -0.202319821990538 0.425418513765316 no 1962 0.419833352343519 2789 15996457 SGTC_2892 9047358 58.44 µM -0.202469135971532 0.425354626939985 no 1963 0.41977499232464 2827 6466771 SGTC_1735 st034310 56.75 µM -0.203348742593628 0.424978310360518 no 1964 0.4194312301023 2970 871153 SGTC_2111 5486399 200 µM -0.204224027980287 0.424603910356435 no 1965 0.41908921770694 2765 689674 SGTC_559 1550-0661 158 µM -0.20483993894896 0.424340497522942 no 1966 0.418848590901719 2844 5830875 SGTC_2383 9036125 200 µM -0.205206428418349 0.424183773316625 no 1967 0.418705423584536 2765 79580 SGTC_779 1360-0071 233 µM -0.205765882426407 0.423944553592425 no 1968 0.418486896383472 2970 7566 SGTC_727 3032-0951 202 µM -0.20586517507396 0.423902099480562 no 1969 0.418448114509337 2841 3652836 SGTC_101 0490-5701 117.494 µM -0.209567639530238 0.422319687961026 no 1970 0.417002569333799 2739 4661669 SGTC_2767 sibutramine 71.45 µM -0.209776639800778 0.422230399599347 no 1971 0.416921003064637 2945 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_168 3970-0862 530.542 µM -0.209814631014225 0.42221416955569 no 1972 0.416906176666196 2857 3135186 SGTC_397 arbidol 50 µM -0.211618197637832 0.421443828984703 no 1973 0.41620245559315 2921 131410 A RNA synthesis inhibitor. SGTC_850 0388-0143 75.9 µM -0.211901179989142 0.421322988580439 no 1974 0.41609206500107 2786 67273 SGTC_858 0438-0351 2.77 µM -0.212605169548833 0.421022399944329 no 1975 0.4158174694565 2806 2799119 SGTC_3020 9089140 49.47 µM -0.212970935404372 0.420866243828716 no 1976 0.415674816404343 2860 17217859 SGTC_488 nitrendipine 139 µM -0.213705464170298 0.420552689696347 no 1977 0.415388374994981 2757 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1648 st011736 69.8 µM -0.21372699126887 0.42054350101195 no 1978 0.415379980831052 2942 2855514 SGTC_2591 skatole 100 µM -0.214182375882417 0.420349133577007 no 1979 0.415202419598488 2920 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2321 7390090 138.78 µM -0.214253108213455 0.42031894531777 no 1980 0.415174841563739 2874 649046 SGTC_508 roscovitine 141 µM -0.214339783524234 0.420281953301423 no 1981 0.415141048044005 2780 160355 A CDKinase inhibitor. SGTC_2924 9010168 62.78 µM -0.214555498297733 0.420189891798101 no 1982 0.415056946526438 2876 2993929 SGTC_2344 7990960 76.95 µM -0.214712383440405 0.420122940006559 no 1983 0.41499578357951 2825 140813 SGTC_3174 9107204 49.47 µM -0.217164990883586 0.41907657496147 no 1984 0.414039883422164 2918 3938802 SGTC_1424 4048-1941 275 µM -0.217594029663423 0.418893591136606 no 1985 0.413872718339269 2909 X1424 SGTC_2878 9043973 25.97 µM -0.21806712029259 0.418691839663518 no 1986 0.41368840755949 2965 6465167 SGTC_1021 4476-0760 85.3 µM -0.21992308803456 0.417900561460027 no 1987 0.412965527413584 2814 746768 SGTC_624 k048-0052 28 µM -0.220034624335049 0.417853019329661 no 1988 0.412922094556924 2847 6835531 SGTC_277 nystatin 15.5 µM -0.220365503270799 0.417711989894919 no 1989 0.412793254729648 2753 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2015 5119600 184 µM -0.220787660283101 0.41753207067404 no 1990 0.412628886081882 2979 2828786 SGTC_3329 9141233 27.5565 µM -0.221098673632462 0.417399530845426 no 1991 0.412507801496187 2948 4909101 YNL103W MET4 SGTC_2279 7948423 32.93 µM -0.221629783779514 0.417173217416191 no 1992 0.412301047465802 2986 1247112 SGTC_1118 chelidonine 707.474 nM -0.222776278350171 0.416684773758777 no 1993 0.411854815603338 2904 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2768 sulfasalazine 50.2 µM -0.222871431940411 0.416644241030213 no 1994 0.411817785597348 2882 5384001 An antioxidant and salicylic acid derivative. SGTC_1398 3558-0053 112 µM -0.224111108737649 0.416116255037434 no 1995 0.411335424398199 2772 4532369 SGTC_2289 7946404 165.07 µM -0.224689736413309 0.415869865691914 no 1996 0.411110324813661 2811 1246120 YPR165W RHO1 SGTC_2210 7115885 190.385 µM -0.225006078785349 0.415735175791324 no 1997 0.41098727266296 2807 2927039 SGTC_3306 9127676 59.7925 µM -0.225213304423921 0.415646950166244 no 1998 0.410906669932994 2880 41905287 SGTC_2296 7971656 126.45 µM -0.225942316434058 0.415336609550649 no 1999 0.410623142473268 2875 666570 SGTC_1026 k007-1105 30.6 µM -0.226063099070778 0.415285197443042 no 2000 0.410576172177655 2816 7066794 SGTC_2962 9082311 13.18 µM -0.227326769914251 0.414747392846022 no 2001 0.410084829285297 2787 16459453 SGTC_946 3434-1334 87.4 µM -0.229853070827939 0.413672706470569 no 2002 0.409102972005739 2967 4047976 SGTC_234 nsc-17383 10.7 µM -0.230006383980507 0.41360750789952 no 2003 0.4090434045009 2960 408974 SGTC_106 0092-0003 11.579 µM -0.231054129280707 0.413162003345434 no 2004 0.408636375220424 2897 1072148 SGTC_1953 st076800 12.1 µM -0.231579623605846 0.412938603587823 no 2005 0.408432267662724 2842 297591 SGTC_551 k048-0028 34.9 µM -0.232274885459872 0.412643075073722 no 2006 0.40816225877795 2980 6836383 SGTC_3317 9138495 8.753 µM -0.232668439257329 0.412475812742111 no 2007 0.408009439245678 2822 17020139 SGTC_1833 st055984 71 µM -0.23423978429384 0.411808141949393 no 2008 0.40739941530641 2860 676288 SGTC_370 0180-0345 38.7 µM -0.234607931487571 0.41165175156924 no 2009 0.407256526460019 2744 3989527 SGTC_1991 st073000 8.92 µM -0.234848263015196 0.411549665357986 no 2010 0.407163253321691 3027 4301969 YIL048W NEO1 SGTC_2749 bexarotene 57.39 µM -0.235869269124683 0.411116036924818 no 2011 0.406767057593064 2918 82146 An retinoic acid receptor inhibitor. SGTC_2677 mitomycin C 100 µM -0.23614766907318 0.410997817337822 no 2012 0.406659042582036 2840 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_491 tetrandrine 80.3 µM -0.236617835187173 0.410798184638914 no 2013 0.406476641297207 2929 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_632 0781-2353 4.65 µM -0.236805197798272 0.410718636842791 no 2014 0.406403959488405 2903 6811515 YHR007C ERG11 SGTC_2445 5742597 35.57 µM -0.237591158302004 0.410384984775306 no 2015 0.406099104414508 2827 1774255 SGTC_75 0159-0059 199.013 µM -0.237906239048092 0.41025124645141 no 2016 0.405976908185901 3136 5377270 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.241468892607904 0.40873978191441 no 2017 0.404595861675158 3070 6710655 SGTC_2728 chlorpromazine 9.18 µM -0.242669616649715 0.408230676240832 no 2018 0.404130673188911 2795 2726 A thorazine and dopamine antagonist. SGTC_1876 myriocin 605 nM -0.243103413746917 0.408046784785942 no 2019 0.403962643373457 2986 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_590 k048-0076 22.4 µM -0.243407082962895 0.407918068047661 no 2020 0.403845028687423 2953 6832814 SGTC_2231 micatex 6.853 µM -0.243455891108554 0.407897380590426 no 2021 0.403826125524841 2861 20737 An antifungal of unknown mechanism. SGTC_3321 9137793 26.8275 µM -0.243716043187565 0.407787118800298 no 2022 0.403725373652797 2832 4904192 SGTC_1775 st081588 35.1725 µM -0.245226861978579 0.407146924194175 no 2023 0.403140389205911 2849 1426443 YGL099W LSG1 SGTC_584 0986-0246 15.4 µM -0.245780472013342 0.406912399377324 no 2024 0.402926087264863 2830 53315 YDR232W HEM1 SGTC_2952 9073731 13.78 µM -0.247594403057759 0.406144201317759 no 2025 0.402224120816117 2879 16457353 SGTC_547 1120-0019 610 nM -0.247699820819045 0.406099568073734 no 2026 0.402183335257822 2815 3676939 SGTC_927 2425-1185 123 µM -0.248176455065127 0.405897779250649 no 2027 0.401998941360674 2823 730375 SGTC_3062 9077494 49.47 µM -0.248520794075173 0.405752014752774 no 2028 0.401865741646947 2975 16459633 SGTC_3295 9122362 53.5725 µM -0.249615292731067 0.405288781920563 no 2029 0.40144243550218 2957 4730473 SGTC_1296 1068-0102 11.9 µM -0.251655302488225 0.404425727857668 no 2030 0.400653754330254 2944 767053 SGTC_2657 nystatin 74.44 µM -0.251811683822011 0.404359587723634 no 2031 0.400593312944685 2908 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_517 1365-0151 113 µM -0.253377630407614 0.403697435167252 no 2032 0.399988206062076 3024 768657 SGTC_21 0849-0113 22.993 µM -0.253717613713548 0.403553711343453 no 2033 0.399856862726075 2870 1560156 SGTC_1064 honokiol 6.76 µM -0.254322128159364 0.403298192362291 no 2034 0.399623352943404 2932 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2382 9035899 200 µM -0.255441924083467 0.402824980937752 no 2035 0.399190896881003 2876 6462679 SGTC_561 1550-0330 72.9 µM -0.255536731486389 0.402784923067678 no 2036 0.399154288706438 2867 6812934 SGTC_1999 st074831 12.5 µM -0.25606738924413 0.402560729265248 no 2037 0.398949401134689 2882 17112523 SGTC_1290 0986-0249 10.2 µM -0.256748679332588 0.402272942870629 no 2038 0.398686395068204 2917 53329 SGTC_3235 9132602 49.47 µM -0.257031055053454 0.402153678961027 no 2039 0.398577399874215 2961 4912240 SGTC_1588 farnesol 29.9 µM -0.257251496032721 0.402060580073741 no 2040 0.39849231658597 2864 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_276 colchicine 750 µM -0.257271640717309 0.40205207264167 no 2041 0.398484541611528 2973 2833 A microtubule depolymerizer. SGTC_3038 9091290 49.47 µM -0.257736567609054 0.401855739260646 no 2042 0.398305111200991 3011 25236843 SGTC_2587 piperic acid 92.2 µM -0.257742851050369 0.401853086003775 no 2043 0.398302686363766 2942 5370536 SGTC_944 3370-0224 231 µM -0.258386641253929 0.401581262027733 no 2044 0.398054262691069 2902 4580514 SGTC_2724 maprotiline 69.64 µM -0.258937738118251 0.401348613266302 no 2045 0.397841640044579 2922 4011 A tricyclic antidepressant. SGTC_1151 3909-8316 15.3 µM -0.262290916905747 0.399933805809301 no 2046 0.396548582111457 2980 800431 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.262441522835561 0.399870291279312 no 2047 0.396490531796228 3076 6728940 SGTC_87 0100-0052 35.5 µM -0.262699118441598 0.399761662495695 no 2048 0.39639124815522 2933 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1896 st058441 89 µM -0.263795953819634 0.399299210903015 no 2049 0.395968576279329 2903 688759 SGTC_1680 diphenhydramine 100 µM -0.266082442111676 0.398335628576534 no 2050 0.395087858443438 2924 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.266958783277087 0.397966480800445 no 2051 0.394750447942775 2905 2724 A muscle relaxant with antifungal properties. SGTC_2472 5377652 49.4 µM -0.26755340737447 0.397716054806025 no 2052 0.394521549601675 2921 1610903 SGTC_2884 9058502 51.95 µM -0.267656347938488 0.397672705654334 no 2053 0.394481926708789 2995 6471554 SGTC_264 promethazine 12.5 mM -0.267744915619554 0.397635410057728 no 2054 0.394447836961608 2911 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2198 6589944 200 µM -0.268024313345594 0.397517762609072 no 2055 0.394340301928 2904 5290268 SGTC_867 0518-0118 155 µM -0.269029068477062 0.397094762264117 no 2056 0.393953656805416 2941 6848158 SGTC_429 1112-0049 25.5 µM -0.269524585570849 0.396886194869056 no 2057 0.393763012712148 2866 2836170 SGTC_1135 dihydrocapsaicin 536.708 nM -0.269736852340534 0.396796858984168 no 2058 0.393681353475825 2823 107982 A Capsaicinoid. SGTC_1707 st032323 6.317 µM -0.269968646701313 0.396699310785119 no 2059 0.39359218729632 2894 3132057 YMR211W DML1 SGTC_3088 9117578 49.47 µM -0.270261445734821 0.396576098657409 no 2060 0.393479561940461 2941 678341 SGTC_1821 st053465 65.6 µM -0.272228382787051 0.395748664403457 no 2061 0.392723209671672 2964 675086 SGTC_954 1189-0853 2.85 µM -0.27262572307115 0.395581571586102 no 2062 0.392570468276538 2838 2828194 SGTC_208 k072-0098 12.366 µM -0.273155856666654 0.395358665317519 no 2063 0.392366705632641 2878 5948901 SGTC_170 4197-0004 226 µM -0.273972647770382 0.395015294653534 no 2064 0.392052820808599 3024 218692 SGTC_1831 st055328 12 µM -0.275168540143331 0.394512700790814 no 2065 0.391593377826412 3052 1103068 SGTC_1651 st011928 86.1 µM -0.276280569367363 0.394045509312448 no 2066 0.391166289365916 3005 720198 SGTC_1428 4049-0204 61.7 µM -0.27665893812643 0.393886581790512 no 2067 0.39102100209342 2990 X1428 SGTC_812 4251-0442 148 µM -0.278187006819047 0.393244921927091 no 2068 0.390434404209729 3022 5723007 SGTC_644 1498-1197 63.3 µM -0.278526084590308 0.393102577124435 no 2069 0.390304272150648 3004 6741615 SGTC_120 rhodamine 6G 52.259 µM -0.278531089208961 0.393100476293176 no 2070 0.390302351558409 2878 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_22 0964-0034 14.468 µM -0.278751507608848 0.393007952479068 no 2071 0.39021776557804 2918 138402 SGTC_2054 5233173 129 µM -0.2788410581237 0.392970364080424 no 2072 0.390183401881959 3064 6889 SGTC_997 3996-0078 137 µM -0.278916034358223 0.392938893933502 no 2073 0.390154631512045 2956 735687 SGTC_1430 4049-0248 69.1 µM -0.279153335247417 0.392839295066959 no 2074 0.390063576832742 3021 22774488 SGTC_733 4069-0007 56.1 µM -0.282380317312018 0.391485579581769 no 2075 0.38882595282728 2923 5717425 YNL287W SEC21 SGTC_1729 st035615 45.989 µM -0.282588090234532 0.391398463888307 no 2076 0.38874630549306 3012 17385451 SGTC_3259 9138485 49.47 µM -0.282620197727379 0.391385002242127 no 2077 0.388733997876041 3202 17646153 SGTC_1176 0848-0131 83.3 µM -0.283435237263955 0.391043325804853 no 2078 0.388421609965021 2997 6769040 SGTC_1998 st075797 76.8 µM -0.283802764190637 0.390889280657326 no 2079 0.388280768037697 3019 24208315 SGTC_1071 trifluoperazine 6.31 µM -0.284326820944525 0.390669657249714 no 2080 0.388079966902637 3055 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1366 1683-0113 21.9 µM -0.286055615827292 0.389945395905226 no 2081 0.387417762560607 2904 708623 SGTC_3089 9117425 49.47 µM -0.288220895929259 0.389038812404587 no 2082 0.386588827259178 2971 9401657 SGTC_1678 st019265 80.2 µM -0.288547701948297 0.388902033956502 no 2083 0.386463760772202 3147 5367020 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.28913882887915 0.388654664002388 no 2084 0.38623757039881 2926 115019 SGTC_809 3998-0021 90 µM -0.289612155688978 0.388456622618664 no 2085 0.386056483240996 3084 715485 SGTC_1581 himbacine 57.9 µM -0.290991869146929 0.38787951189573 no 2086 0.385528769023527 2909 5281825 An alkaloid muscarinic receptor antagonist. SGTC_262 fenpropimorph 62.5 µM -0.2935737669797 0.386800213849891 no 2087 0.384541811905711 2902 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2290 7904846 200 µM -0.293838370053094 0.386689652413874 no 2088 0.384440706792184 2984 2962154 SGTC_2872 9044037 25.97 µM -0.294026576314737 0.386611018127661 no 2089 0.384368797764634 2905 6465195 SGTC_8 0354-0001 70 µM -0.2940494179612 0.386601474996949 no 2090 0.384360070798707 2943 4993152 SGTC_2213 7173844 200 µM -0.295413088166118 0.386031864555108 no 2091 0.383839168152818 2956 892728 SGTC_3104 9120930 49.47 µM -0.29619847507799 0.385703916708398 no 2092 0.383539256664902 3006 17014836 SGTC_1454 4239-0054 42.6 µM -0.297531027901471 0.385147680065807 no 2093 0.383030561545955 3119 1340767 SGTC_2030 5175110 200 µM -0.299059040389092 0.384510145082634 no 2094 0.382447498945687 3060 2831986 SGTC_2582 agaric acid 100 µM -0.300971583915657 0.383712611772019 no 2095 0.381718081600059 3051 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1168 k815-0004 80.5 µM -0.301503662719002 0.383490821566775 no 2096 0.381515228715811 2922 642433 SGTC_3094 9117742 49.47 µM -0.301641757090152 0.383433264940695 no 2097 0.381462586113766 2892 17149698 SGTC_479 n-linoleoylglycine 10 µM -0.301661744971093 0.383424934365348 no 2098 0.381454966766432 2948 6433346 An anti-infammatory. SGTC_105 0111-0055 734.78 µM -0.302076277240028 0.383252177214981 no 2099 0.381296958107931 3028 5179370 SGTC_869 0564-0080 44.1 µM -0.305517621846124 0.3818188892837 no 2100 0.379985975426511 2990 6843321 SGTC_2841 9004761 38.96 µM -0.305809376026696 0.381697450543283 no 2101 0.379874894614045 2963 2991039 SGTC_210 3551-0445 56.827 µM -0.306173917489953 0.381545731441627 no 2102 0.379736115117658 3071 2865180 YOR207C RET1 SGTC_324 1315-0088 19.6 µM -0.306252459630635 0.381513045243028 no 2103 0.379706216462158 3018 6787421 SGTC_505 gw-5074 63.9 µM -0.306565232364909 0.381382889722955 no 2104 0.379587160326407 3043 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1472 k841-0093 193 µM -0.30691510152921 0.381237312994218 no 2105 0.37945399705692 3067 X1472 SGTC_2905 7799065 20.05 µM -0.307126021107493 0.381149559784197 no 2106 0.379373726124524 3124 1296806 SGTC_729 4092-0585 94.1 µM -0.30714801074143 0.381140411336243 no 2107 0.379365357696541 2928 2169061 SGTC_2592 piperlongumine 83.33 µM -0.307161184027672 0.38113493082555 no 2108 0.379360344466115 3029 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1155 4088-0394 48.2 µM -0.310576789244976 0.379714736690576 no 2109 0.378061187323762 2925 2326248 SGTC_1822 st052468 42 µM -0.310726323476609 0.379652597892208 no 2110 0.378004341963 3006 2873678 SGTC_3305 9127027 53.8275 µM -0.311056504689396 0.379515402433448 no 2111 0.377878833102156 2975 41905295 SGTC_2468 5987765 72.9 µM -0.312159582519635 0.379057166418244 no 2112 0.377459623426624 2999 26772094 SGTC_61 0978-8327 98.565 µM -0.312266697826912 0.379012678062277 no 2113 0.377418923396352 3064 6150059 YHR072W ERG7 SGTC_428 3448-4153 16.5 µM -0.312615785760176 0.378867701989655 no 2114 0.377286291771735 2889 3834874 SGTC_1274 0865-0114 173 µM -0.312653633910526 0.378851984692238 no 2115 0.377271912706486 2999 870624 SGTC_177 1327-0068 8.361 µM -0.312731642074138 0.378819590676228 no 2116 0.37724227680227 3034 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1804 st050076 49.1 µM -0.313317650117247 0.37857626960817 no 2117 0.377019670944376 3083 3895976 SGTC_1351 1496-0003 46.5 µM -0.313597323418405 0.378460161188827 no 2118 0.376913446335259 3083 3891978 SGTC_249 wiskostatin 11.211 µM -0.313664153680411 0.378432417739873 no 2119 0.376888064459957 3032 2775510 A n-wasp and actin depolymerizer. SGTC_3127 9126946 49.47 µM -0.314096621204626 0.378252901341338 no 2120 0.37672382783123 3035 27243249 SGTC_2235 salicylic acid 500 µM -0.315093768531873 0.377839087695652 no 2121 0.376345229855986 2975 338 A COX inhibitor and kinase inhibitor. SGTC_1768 st044301 37.178 µM -0.318929354550917 0.376248639293056 no 2122 0.37489004203108 3006 3931349 SGTC_3154 9100113 49.47 µM -0.320596947732453 0.375557815017019 no 2123 0.374257925486221 2980 25237525 SGTC_3303 9125618 40.5795 µM -0.321842954359897 0.375041899159747 no 2124 0.373785835649923 3047 22695467 SGTC_2184 6075246 200 µM -0.32333632494427 0.374423855412969 no 2125 0.373220273423684 3031 2267320 SGTC_2327 6189656 200 µM -0.323633761648842 0.374300797242626 no 2126 0.373107662173731 3084 5349088 SGTC_2636 apigenin dimethyl ether 100 µM -0.323809642353735 0.374228036330129 no 2127 0.373041077824888 3113 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_196 k015-0023 18.111 µM -0.324360084502744 0.374000350299499 no 2128 0.372832717727829 2968 5211998 SGTC_3187 9109394 49.47 µM -0.324620143649561 0.373892794178622 no 2129 0.372734289892825 3020 17098090 SGTC_2936 9038235 15.59 µM -0.325098995253811 0.373694774839832 no 2130 0.372553074682099 2927 4749415 SGTC_1119 parthenolide 318.541 nM -0.325778950857236 0.373413650323093 no 2131 0.372295802732792 3176 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1749 st037932 54.2 µM -0.326090778525764 0.373284749127402 no 2132 0.372177836858006 3100 594497 SGTC_1105 epirubicin 18.1 µM -0.32620124572651 0.373239088349728 no 2133 0.37213604947271 2968 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1777 st045864 34.765 µM -0.326963834115208 0.372923926828146 no 2134 0.371847619655392 3050 4691462 SGTC_1597 7-benzyloxygramine 47.5 µM -0.328070049695971 0.372466902696266 no 2135 0.371429349373876 2984 260807 SGTC_2959 9079155 11 µM -0.328087495856636 0.372459696390653 no 2136 0.371422754034586 3137 16189457 SGTC_1127 asiatic acid 681.4 nM -0.328101306366244 0.372453991857582 no 2137 0.371417533142072 2975 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3298 9116858 71.43 µM -0.330330958915328 0.371533385137931 no 2138 0.370574951387286 3135 2506942 SGTC_2906 7926292 26.41 µM -0.331276692056637 0.37114312053735 no 2139 0.370217747659263 3110 2966319 SGTC_3276 9139060 49.47 µM -0.336625607845735 0.368938350349544 no 2140 0.368199574740447 2970 4870619 SGTC_265 mycophenolic acid 32.932 µM -0.336816945713686 0.368859562114716 no 2141 0.36812744895147 3258 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2442 5158906 48.48 µM -0.33726891466241 0.368673474290579 no 2142 0.367957095403603 3127 1893835 SGTC_1461 k072-0203 53.8 µM -0.338879092005276 0.368010771299225 no 2143 0.367350407826834 3057 5418714 SGTC_1637 st007924 17.4 µM -0.340472560921014 0.367355331516844 no 2144 0.366750341516448 2987 683336 SGTC_54 0159-0055 9 µM -0.341367174993728 0.366987520096775 no 2145 0.366413591561755 3241 3319099 SGTC_596 1155-0152 116 µM -0.342095855284435 0.366688020834483 no 2146 0.366139378250936 3034 280313 SGTC_2200 6600604 21.907 µM -0.342346922253307 0.366584847078843 no 2147 0.366044913813825 3001 2904777 SGTC_519 k048-0011 62.8 µM -0.342347056224529 0.366584792027124 no 2148 0.366044863409058 3094 6836379 SGTC_480 am 92016 50 µM -0.343076000667653 0.366285293403473 no 2149 0.36577064267775 3072 2129 K+ channel blocker. SGTC_140 0062-0056 502.533 µM -0.343522525331897 0.366101871723732 no 2150 0.365602698960763 2961 3758964 SGTC_1930 st074634 34.3 µM -0.344892496229007 0.365539311444157 no 2151 0.365087596018679 2990 684253 YOR116C RPO31 SGTC_2997 9067075 71.4286 µM -0.345324061107033 0.365362154906648 no 2152 0.364925379909775 3108 27209819 SGTC_3248 9135562 49.47 µM -0.346902713506069 0.364714366143962 no 2153 0.364332204006981 3067 17650701 SGTC_3175 9106517 49.47 µM -0.347786559497247 0.364351854692836 no 2154 0.364000242134879 3092 41468073 SGTC_3158 9100007 49.47 µM -0.348699535427964 0.36397752289462 no 2155 0.363657446537467 3015 19297233 SGTC_974 1326-0144 138 µM -0.348984850831288 0.363860566528534 no 2156 0.363550341364927 3047 5411856 SGTC_1090 efavirenz 20.7 µM -0.350311255435713 0.363317014011903 no 2157 0.36305255959018 3067 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1607 st000305 50.6 µM -0.350339886732098 0.363305284110758 no 2158 0.363041817197326 3157 5457690 SGTC_2942 9052777 62.25 µM -0.351408132054241 0.36286772842392 no 2159 0.362641091224012 3047 6469503 SGTC_2721 ifenprodil 61.44 µM -0.351514415171311 0.362824204400166 no 2160 0.362601229944984 3151 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.352143477556677 0.362566633218272 no 2161 0.362365331809581 3028 165521 SGTC_3082 9117008 49.47 µM -0.353107919958924 0.36217186063043 no 2162 0.362003767795864 3046 41448529 SGTC_1477 0139-0234 16 µM -0.355020813284153 0.361389295168894 no 2163 0.361286999414123 3059 620880 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.355342502178341 0.361257748947806 no 2164 0.361166509099947 3042 4174840 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.355479803262689 0.361201608270615 no 2165 0.361115086429589 2941 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2664 lyso-paf C-16 73.48 µM -0.356038503692823 0.360973193571005 no 2166 0.360905865118983 3018 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_62 0180-0423 3.232 µM -0.3592004585131 0.359681421073666 no 2167 0.359722566820806 3073 30102 YGL099W LSG1 SGTC_1840 st055363 71 µM -0.359746512645538 0.359458500037406 no 2168 0.359518352715956 3075 676033 SGTC_1045 1348-1485 165 µM -0.360044197211237 0.359336993482842 no 2169 0.359407041107475 3034 6810614 SGTC_904 1141-0088 396 µM -0.360062702178308 0.35932944073976 no 2170 0.359400122037182 3071 1378119 SGTC_134 0269-0018 6.916 µM -0.362162526354721 0.358472761863621 no 2171 0.358615290539874 3106 4378915 SGTC_857 0438-0306 1.35 µM -0.36335785927003 0.357985411758422 no 2172 0.358168788507482 3137 4686136 SGTC_2128 5255449 168.493 µM -0.364040923161811 0.357707023072337 no 2173 0.357913725340705 3041 736008 SGTC_3055 9094636 49.47 µM -0.364219264497065 0.357634350948217 no 2174 0.357847141265972 3224 25236176 SGTC_1936 st074407 74.3 µM -0.364605193236518 0.35747710692134 no 2175 0.357703068849585 3047 809813 SGTC_368 fentichlor 4.58 µM -0.36486713381448 0.357370394804227 no 2176 0.357605294437646 3089 7329 A pesticide. SGTC_1714 st033236 13.627 µM -0.365820675612757 0.356982025131653 no 2177 0.357249445392522 3235 2916566 SGTC_509 pifithrin 175 µM -0.365862326226591 0.356965064556105 no 2178 0.357233904767393 3153 4817 A p53 inhibitor. SGTC_1028 k015-0029 4.8 µM -0.366391080270977 0.356749774836984 no 2179 0.35703663731101 3031 4588309 SGTC_2325 6158266 200 µM -0.366476882947052 0.356714843359399 no 2180 0.357004629667602 3110 3623240 SGTC_1220 1838-0075 193 µM -0.367941543980645 0.356118744771557 no 2181 0.35645841109895 3071 5529645 SGTC_955 1216-0110 33 µM -0.369365204048646 0.355539669880908 no 2182 0.355927765123538 3018 3619719 SGTC_3234 9132280 49.47 µM -0.369469180599568 0.355497390378171 no 2183 0.355889020486886 3124 17612295 SGTC_459 nigericin 15.3 µM -0.37010486535847 0.355238943515832 no 2184 0.355652178544371 3197 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1502 4534-4282 27.7 µM -0.371007280062163 0.354872168076094 no 2185 0.355316054688532 3106 3278949 SGTC_2153 5569715 200 µM -0.371669714770371 0.354603015136597 no 2186 0.355069388166652 3107 2054701 SGTC_2312 7706453 155.7 µM -0.372208568069199 0.354384127913965 no 2187 0.354868783637176 3075 976098 SGTC_2482 5981709 142.65 µM -0.372802629393243 0.354142870410656 no 2188 0.354647672867378 3085 877755 SGTC_391 gliotoxin 8.33 µM -0.373776481940093 0.353747500477245 no 2189 0.354285309027534 3234 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_566 0958-0068 16.5 µM -0.374535770974789 0.353439349579686 no 2190 0.354002874275563 3228 6815365 SGTC_275 trichlorophene 5.69 µM -0.375212555280166 0.353164763458885 no 2191 0.353751196714189 3150 62616 SGTC_1401 3807-4679 7.6 µM -0.375539072147781 0.353032315783467 no 2192 0.353629796872872 3115 3291456 SGTC_119 0121-0043 24.815 µM -0.376465957228198 0.352656432951442 no 2193 0.353285259668785 3094 1092378 SGTC_2065 5221596 34.26 µM -0.378289575870251 0.351917314823006 no 2194 0.352607744169563 3190 788581 SGTC_1655 st012546 55.1 µM -0.380688421400152 0.350945907423743 no 2195 0.351717230740561 3141 720985 YLR208W SEC13 SGTC_346 4513-0042 7.16 µM -0.380925403791873 0.350849994636178 no 2196 0.351629300801154 3029 2827372 SGTC_2033 5192550 145 µM -0.383598311113303 0.349768860603339 no 2197 0.350638095982043 3098 182073 SGTC_1285 0929-0069 65.5 µM -0.384435669362192 0.349430416986178 no 2198 0.350327783774491 3105 1206237 SGTC_2765 myclobutanil 7.74 µM -0.384975286695146 0.349212377738614 no 2199 0.350127862722271 3183 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3087 9117406 49.47 µM -0.385021810767644 0.349193581424359 no 2200 0.350110628115357 3182 42546093 SGTC_2737 bleomycin 30.5 nM -0.385362270318935 0.349056042716633 no 2201 0.349984515997562 3127 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_543 3844-1095 191 µM -0.386072967467056 0.348768999486137 no 2202 0.349721314787966 3163 4230703 SGTC_3166 9102297 49.47 µM -0.388346996157614 0.347851124974821 no 2203 0.348879631509501 3125 25237072 SGTC_340 k038-0059 454 µM -0.388559687609758 0.347765321026948 no 2204 0.34880094623727 3147 23733424 SGTC_1505 k297-0037 20.6 µM -0.388775258125949 0.347678363563132 no 2205 0.348721202489538 3107 4089396 SGTC_49 0717-0965 32.132 µM -0.392942905336432 0.345998785744705 no 2206 0.347180825628846 3338 5889349 YGL099W LSG1 SGTC_1282 0886-0010 32.4 µM -0.393144774054987 0.345917508435281 no 2207 0.347106278068667 3268 2836211 YNL267W PIK1 SGTC_1356 1502-0781 85.8 µM -0.394221052720645 0.345484292086033 no 2208 0.346708921912228 3083 567702 SGTC_2681 menadione 3.18 µM -0.394227312057878 0.345481773211488 no 2209 0.346706611492011 3188 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_951 1171-0579 82.7 µM -0.39664626143709 0.344508855894166 no 2210 0.345814166642017 3096 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2945 9067681 61.76 µM -0.397085081278371 0.344332469624144 no 2211 0.345652360458004 3161 16456930 SGTC_3294 9122953 26.2835 µM -0.397738241312361 0.34406999072886 no 2212 0.345411572762955 3101 16459826 SGTC_1463 k081-0032 34.1 µM -0.398314753823711 0.343838375809456 no 2213 0.345199093170024 3168 977755 SGTC_1619 st003326 88.7 µM -0.398636057191804 0.343709317036265 no 2214 0.345080694689666 3247 2849032 SGTC_1089 terbinafine 2.25 µM -0.399949536628457 0.343181917828634 no 2215 0.344596842730151 3209 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2981 9013952 38.96 µM -0.400181578675548 0.343088778075036 no 2216 0.344511390814098 3132 2996344 SGTC_1254 0550-0035 264 µM -0.400339716545943 0.343025308306647 no 2217 0.344453159431874 3233 15121435 SGTC_2406 ethylparaben 405.7 µM -0.400355871555031 0.343018824627197 no 2218 0.34444721085238 2982 8434 A possible steroid mimic. SGTC_320 4092-0846 5.34 µM -0.400594208847679 0.34292317529568 no 2219 0.344359455030857 3192 1359356 SGTC_304 1310-0298 97 µM -0.401185074572945 0.342686092957271 no 2220 0.344141934336047 3172 1550234 SGTC_1617 st002906 78 µM -0.401340831990548 0.342623606275401 no 2221 0.344084602546075 3089 5150859 SGTC_3338 9144300 39.5675 µM -0.402105365444666 0.342316953604471 no 2222 0.34380324211895 3150 4901274 SGTC_2082 5219693 150 µM -0.402112600693784 0.342314052058263 no 2223 0.343800579845492 3092 2834649 SGTC_1944 st076371 56.9 µM -0.402220047413964 0.34227096388098 no 2224 0.343761044792782 3082 24208455 SGTC_1243 0416-0003 5.65 µM -0.404688189917338 0.341281758112481 no 2225 0.342853362186318 3115 2141977 SGTC_1865 st057639 52.2 µM -0.40495803690142 0.341173672213619 no 2226 0.342754178290516 3106 688818 SGTC_457 grayanotoxin iii 135 µM -0.404980062359907 0.341164850598268 no 2227 0.342746083177976 3220 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2456 5770359 74.46 µM -0.40679608466996 0.340437798157362 no 2228 0.342078881322342 3259 3118787 SGTC_648 0375-0473 33.3 µM -0.407937639927325 0.339981074695083 no 2229 0.341659728990751 3124 1713139 SGTC_2864 9034755 47.6 µM -0.40812428038635 0.339906424249832 no 2230 0.341591217538291 3218 4930451 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.410121412412152 0.339108026308408 no 2231 0.340858443034421 3211 616764 SGTC_1331 1472-0049 76.2 µM -0.410831006076273 0.338824524105627 no 2232 0.340598227935554 3078 24051409 SGTC_1419 3993-2473 62.6 µM -0.412141402151811 0.338301224808476 no 2233 0.340117892022738 3175 704026 SGTC_2782 7736369 71.43 µM -0.413669636477824 0.337691327385401 no 2234 0.339558033443465 3145 2950836 YOL077C BRX1 SGTC_2873 9040596 71.43 µM -0.414022884542822 0.337550411469702 no 2235 0.339428673646899 3241 6463863 SGTC_3117 9124945 49.47 µM -0.414265102491078 0.337453800283236 no 2236 0.339339984123058 3072 17592065 SGTC_1363 1636-0063 10.4 µM -0.414520123066889 0.337352094211982 no 2237 0.339246616458899 3153 6072185 SGTC_578 3460-0051 92 µM -0.414968088170201 0.337173467712 no 2238 0.339082632197148 3264 2876744 SGTC_1671 st016596 74.5 µM -0.416955610345185 0.336381384534995 no 2239 0.338355438260888 3178 2829167 SGTC_2823 7987624 58.44 µM -0.418198957443134 0.335886244647336 no 2240 0.337900828985667 3361 2239440 SGTC_948 3448-0295 75.3 µM -0.418701956504368 0.335686015451577 no 2241 0.337716982816759 3160 678569 SGTC_2690 usnic acid 100 µM -0.42077021881245 0.334863191516026 no 2242 0.336961440193554 3372 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3009 9080819 71.4286 µM -0.421957102820307 0.334391366792959 no 2243 0.336528164417145 3206 17027216 SGTC_798 1287-0182 476 µM -0.422012502376743 0.33436935006213 no 2244 0.336507945928464 3305 1649755 SGTC_2520 obtusaquinone 4.71 µM -0.422491834933333 0.334178878906439 no 2245 0.33633302961669 3302 5967872 SGTC_2684 capsaicin 100 µM -0.423227322830219 0.33388670298298 no 2246 0.336064706900536 3252 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2132 5317594 122.667 µM -0.42336225589517 0.333833111131201 no 2247 0.336015489311166 3105 794577 SGTC_176 1486-1328 72.834 µM -0.424596387677774 0.333343103943872 no 2248 0.335565463394414 3207 22310231 SGTC_3216 9129716 49.47 µM -0.425662035997146 0.332920221118569 no 2249 0.33517706459389 3153 8056934 SGTC_2596 sinensetin 100 µM -0.42615025183625 0.332726552610326 no 2250 0.334999182481974 3160 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1326 1431-2094 10.8 µM -0.428534144312594 0.331781537033408 no 2251 0.334131140116964 3082 616278 SGTC_2066 5222451 176 µM -0.428929175172442 0.331625043199951 no 2252 0.333987383755624 3159 2281147 SGTC_1771 st048882 4.1505 µM -0.429268051214563 0.331490818846254 no 2253 0.333864082198846 3141 4580403 SGTC_2519 cryptotanshinone 88.04 µM -0.430227514981391 0.331110905246109 no 2254 0.333515074350809 3298 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2172 5754775 163.918 µM -0.431280562040075 0.330694136042035 no 2255 0.333132191101905 3134 2263357 SGTC_2777 climbazole 1.536 µM -0.431541733161995 0.330590803615157 no 2256 0.333037257330311 3231 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3255 9139072 49.47 µM -0.431890760266432 0.33045273110255 no 2257 0.332910405262625 3234 17646060 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.433125283845411 0.329964548068912 no 2258 0.332461877657619 3246 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_362 0310-0100 9.03 µM -0.43313092659201 0.329962317351229 no 2259 0.332459828082687 3281 790235 SGTC_1170 0310-0127 64.8 µM -0.434592687887968 0.32938465071353 no 2260 0.331929051748994 3216 774975 SGTC_825 1988-2224 89.6 µM -0.436805405210709 0.328510991872568 no 2261 0.331126239344001 3172 1180859 SGTC_964 1287-0107 19.4 µM -0.438199447843007 0.327961055302349 no 2262 0.330620854408072 3315 51516812 YPR165W RHO1 SGTC_148 3253-0744 288.01 µM -0.438298624999144 0.327921945047666 no 2263 0.330584911274577 3260 6893655 SGTC_925 2064-1272 59.6 µM -0.440014788590065 0.327245479539551 no 2264 0.329963198213693 3183 6815817 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.441242505602509 0.326761894278319 no 2265 0.329518722129298 3208 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2611 pyromycin 23.93 µM -0.441972309613095 0.326474569674317 no 2266 0.329254621839356 3188 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3102 9121669 49.47 µM -0.443211725460688 0.325986846236425 no 2267 0.328806299256068 3194 41905072 SGTC_1785 bathophenanthroline 24 µM -0.444191745624154 0.32560140839631 no 2268 0.328451979785282 3173 72812 An iron chelator. SGTC_1104 tacrolimus 29.8 µM -0.445604457489229 0.325046122784869 no 2269 0.327941495076133 3269 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.445731254795063 0.32499630235557 no 2270 0.327895692453982 3286 140250 A respiratory chain inhibitor. SGTC_1987 st072290 61.9 µM -0.446580115061495 0.324662853954645 no 2271 0.327589127828855 3218 54697379 SGTC_1952 st077036 64.1 µM -0.44949554918967 0.323518687290478 no 2272 0.326537109042419 3260 2937007 SGTC_2089 5281248 129.67 µM -0.450177010194925 0.323251486762045 no 2273 0.326291405881941 3228 2737878 SGTC_3077 9117319 49.47 µM -0.451582846996322 0.322700546943199 no 2274 0.325784764693042 3263 17154678 SGTC_2357 9067248 200 µM -0.451794095344549 0.322617793449099 no 2275 0.325708661922182 3283 9150235 SGTC_149 3970-0822 46.1 µM -0.45185669920018 0.322593270978885 no 2276 0.325686110114193 3328 3114250 YBL034C STU1 SGTC_3264 9137442 49.47 µM -0.453439261116344 0.321973624384253 no 2277 0.325116235383682 3402 17015726 SGTC_107 0358-0022 2.6945 µM -0.453882260422745 0.32180025808927 no 2278 0.324956786144532 3245 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_888 0916-0002 6.97 µM -0.454821518236826 0.321432811025132 no 2279 0.324618824090884 3342 2802138 YIL048W NEO1 SGTC_1978 st071761 42 µM -0.455211282015045 0.321280382791863 no 2280 0.324478622354675 3182 5147680 SGTC_2377 9073351 62.6 µM -0.455375898837949 0.321216013731111 no 2281 0.324419415588614 3181 7337946 YHR072W ERG7 SGTC_2654 protoveratrine a 100 µM -0.456488703840655 0.32078102167034 no 2282 0.32401929601742 3224 5702278 A heart drug and vasodilator. SGTC_1700 st030840 7.9285 µM -0.457961769811394 0.320205583019039 no 2283 0.323489953798802 3293 5499307 SGTC_531 3788-1495 174 µM -0.458311571864052 0.320068999749923 no 2284 0.323364305806063 3139 2896655 SGTC_2448 5185112 27.17 µM -0.462638353767206 0.31838159072317 no 2285 0.321811806150875 3311 5718189 SGTC_2732 terfenadine 20 µM -0.464429883887275 0.317684007792759 no 2286 0.321169891872813 3273 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1233 0325-0408 14.2 µM -0.468520392341722 0.316093679627384 no 2287 0.319706245741258 3330 12874 SGTC_2197 6588183 93.1375 µM -0.468943512706456 0.315929370157096 no 2288 0.319555006444665 3216 884136 SGTC_524 r073-0010 27.8 µM -0.470260104861921 0.315418333306222 no 2289 0.319084598418939 3173 2772106 SGTC_1511 0906-3109 28.5 µM -0.471517484330648 0.31493060931453 no 2290 0.318635618422877 3288 2882180 SGTC_902 1120-0002 2.07 µM -0.472331438246178 0.314615057256183 no 2291 0.318345116891927 3290 3280475 SGTC_1164 k060-0068 93.7 µM -0.474800686591494 0.313658612772388 no 2292 0.317464521789518 3248 5963676 SGTC_2413 inermin 26.06 µM -0.475840612699378 0.313256179374885 no 2293 0.317093966926748 3445 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1547 harmine 94.2 µM -0.477161871293064 0.312745195821727 no 2294 0.316623429861129 3288 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.477219790581806 0.312722804337254 no 2295 0.316602809966053 3258 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_752 1896-0090 130 µM -0.479242838763035 0.311941131967511 no 2296 0.315882940863332 3306 772567 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.479490516750122 0.311845491360405 no 2297 0.315794856527061 3305 3256 An antibiotic and ribosome inhibitor. SGTC_2733 amorolfine 100 µM -0.481585634916862 0.311036971649165 no 2298 0.315050166441044 3306 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1415 3966-0071 78.1 µM -0.482737452620308 0.31059286559041 no 2299 0.31464108341528 3311 2893185 SGTC_1853 st056710 91.2 µM -0.485888819696004 0.309379205261911 no 2300 0.313522997863348 3404 269167 SGTC_447 ml7 120 µM -0.486073964081483 0.309307966569466 no 2301 0.313457362902628 3350 4216 Selective myosin light chain kinase inhibitor. SGTC_668 1682-0499 62.6 µM -0.488125204060131 0.308519183429146 no 2302 0.312730579799761 3304 682214 SGTC_256 clotrimazole 625 nM -0.488577431649592 0.308345402637991 no 2303 0.312570446991094 3302 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1513 0337-0559 19 µM -0.489718024367151 0.307907289551153 no 2304 0.312166722775736 3228 775073 SGTC_1530 rhein 70.4 µM -0.491243026425092 0.307321948602737 no 2305 0.311627285314123 3331 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2812 7970281 58.44 µM -0.491343082371756 0.307283561297318 no 2306 0.31159190673491 3385 2233435 SGTC_1949 st076024 69.1 µM -0.492123727403651 0.306984132790252 no 2307 0.311315939783106 3201 2921930 SGTC_1772 st048439 82.2 µM -0.492729345606674 0.306751927170606 no 2308 0.311101919826082 3324 2927068 YDL195W SEC31 SGTC_2569 tetrandrine 100 µM -0.493746907135885 0.306361949187078 no 2309 0.310742466659126 3250 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.493967178069073 0.306277559738131 no 2310 0.310664679810262 3217 6708514 SGTC_301 4119-0100 24.5 µM -0.495750956784275 0.305594543389562 no 2311 0.310035065210829 3303 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1629 st005085 44.9 µM -0.495864396546973 0.305551129664545 no 2312 0.309995043550684 3234 24207091 SGTC_2423 st077119 87.2 µM -0.497951238040277 0.304752977616611 no 2313 0.309259205837995 3322 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1154 4088-0362 150 µM -0.498369188681541 0.30459323594639 no 2314 0.309111924738139 3336 6618304 SGTC_2361 9034121 116 µM -0.500987928663401 0.303593196678572 no 2315 0.308189809244909 3285 6496917 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.501008535788453 0.303585333086309 no 2316 0.308182557814518 3291 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1002 4049-0206 172 µM -0.501092616356597 0.303553249237674 no 2317 0.308152971523569 3284 4662749 SGTC_1559 coumarin 343 70.1 µM -0.501190247279841 0.3035159966824 no 2318 0.308118618694378 3412 108770 A hepatotoxic, DNA x-linker. SGTC_1286 0929-0070 131 µM -0.501461286065737 0.303412588438719 no 2319 0.308023258653274 3390 1420408 SGTC_3099 9120367 49.47 µM -0.501846080759749 0.303265806444668 no 2320 0.30788789793762 3355 24824940 SGTC_1901 st060216 58.6 µM -0.501922733593086 0.303236570603416 no 2321 0.307860936595768 3270 688792 SGTC_1942 st076330 65.2 µM -0.503663931545749 0.302572807186734 no 2322 0.307248779195989 3422 24208414 SGTC_1985 st071382 65.5 µM -0.505185642431416 0.301993248429859 no 2323 0.306714226788338 3368 6123237 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.505275431849082 0.301959066818847 no 2324 0.306682698044148 3341 688788 SGTC_2972 9093619 59.92 µM -0.505490562192424 0.301877176692305 no 2325 0.306607162783849 3226 25236256 SGTC_2563 tomatine 8.54 µM -0.505836604134748 0.301745475542904 no 2326 0.306485679870537 3455 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_917 harmaline 728.087 nM -0.506232411077651 0.301594865860721 no 2327 0.306346752320436 3320 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_530 4358-1714 28 µM -0.506469311763941 0.301504738252357 no 2328 0.30626361390491 3362 1564641 SGTC_1670 st016595 4.04 µM -0.50669871870813 0.301417473150579 no 2329 0.306183114864961 3357 597879 SGTC_1187 1391-0724 117 µM -0.508609685524619 0.30069099443687 no 2330 0.305512919312595 3350 6997986 SGTC_1765 st044815 90.4 µM -0.508892770852563 0.300583443130993 no 2331 0.305413693724792 3339 645695 SGTC_1937 st074714 47.2 µM -0.510164382582657 0.300100539930462 no 2332 0.304968151427717 3258 17250970 SGTC_192 3455-0609 60.9 µM -0.510418307702817 0.300004152186408 no 2333 0.30487921673974 3417 3769639 SGTC_1902 st060212 70.5 µM -0.510737971899505 0.299882830387291 no 2334 0.30476727399816 3425 688944 SGTC_2307 7538926 6.34 µM -0.513811554234982 0.298717452258724 no 2335 0.30369187449233 3303 96582 SGTC_1329 1447-1697 50.6 µM -0.513927385965517 0.298673573831927 no 2336 0.303651379873804 3379 2840515 SGTC_1298 1079-1278 263 µM -0.514300644160325 0.298532199162191 no 2337 0.303520905708031 3376 2840950 SGTC_1950 st077106 7.18 µM -0.515508141755478 0.298075057993386 no 2338 0.303098990844229 3324 13831864 SGTC_835 0312-0010 67.2 µM -0.515674745330732 0.298012009331761 no 2339 0.30304079805869 3313 1626196 SGTC_1836 st055642 81 µM -0.517573552281546 0.297293863692838 no 2340 0.30237791927171 3302 8571 SGTC_612 0302-0167 22.4 µM -0.517864205016719 0.297184006071086 no 2341 0.302276509013664 3358 235821 SGTC_1522 st012842 45.6 µM -0.518697082853016 0.296869307183216 no 2342 0.301985998139252 3321 3491067 YOR116C RPO31 SGTC_1256 0570-0116 285 µM -0.519463234957495 0.296579955032508 no 2343 0.301718872244529 3324 410638 SGTC_379 3970-0972 5.9 µM -0.520512445090336 0.296183910300879 no 2344 0.301353228069157 3366 2898042 YBL034C STU1 SGTC_1897 st060201 15 µM -0.521192322850247 0.295927406859182 no 2345 0.301116400844122 3345 611878 SGTC_2925 9010536 32.5 µM -0.521274959860611 0.295896236623661 no 2346 0.301087620954688 3332 2994177 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.521602544250727 0.295772688392516 no 2347 0.300973545743389 3378 521171 SGTC_2205 7238770 200 µM -0.521646976404167 0.295755932661383 no 2348 0.300958074567767 3406 279867 SGTC_1677 st019204 53.9 µM -0.522593481302968 0.29539910151438 no 2349 0.300628588912122 3355 3945625 SGTC_453 enantio-paf c16 10 µM -0.523525965824486 0.295047749835645 no 2350 0.300304143190073 3404 13871343 A lipid and platelet activating factor SGTC_3140 9094243 49.47 µM -0.523593181120239 0.295022431163548 no 2351 0.300280762628148 3433 19291112 SGTC_1349 flufenamic acid 69 µM -0.524325172215271 0.294746769422859 no 2352 0.300026195850339 3346 3371 A non-steroidal anti-inflammatory. SGTC_2315 7733312 200 µM -0.524330914930671 0.294744607233762 no 2353 0.300024199074732 3290 726316 SGTC_212 3807-4682 38.772 µM -0.524922943717363 0.294521741799238 no 2354 0.299818379484687 3403 3125501 YBL034C STU1 SGTC_1711 st032263 62.8 µM -0.525617620965043 0.294260334216592 no 2355 0.2995769555717 3361 3958979 SGTC_2722 naftopidil 47.16 µM -0.526448630454214 0.293947765565396 no 2356 0.299288267365313 3392 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2477 5967686 25.23 µM -0.52831926963561 0.293244722064088 no 2357 0.298638879673812 3292 776118 SGTC_3023 9089636 49.47 µM -0.529128094597885 0.292940982435278 no 2358 0.298358296665297 3482 17249241 SGTC_657 3534-0529 86.7 µM -0.530241209283189 0.292523211172944 no 2359 0.297972351267887 3415 1049549 SGTC_653 0203-0016 55.2 µM -0.532639103056334 0.291624182013161 no 2360 0.297141714155525 3373 295302 SGTC_913 3487-1245 167 µM -0.534136190970056 0.291063541014391 no 2361 0.296623656096893 3306 4016153 SGTC_823 0417-1665 178 µM -0.53462797683486 0.290879483177449 no 2362 0.296453566941781 3386 3429856 SGTC_2238 6671620 73.2395 µM -0.535226210105598 0.290655659256186 no 2363 0.296246722148479 3378 729941 SGTC_309 k408-0051 1.48 µM -0.537066608858605 0.289967595260483 no 2364 0.295610802370107 3400 3640463 SGTC_528 3492-0019 172 µM -0.53814035510513 0.289566510282575 no 2365 0.295240076958423 3434 2869262 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.539274348331297 0.289143203806168 no 2366 0.294848782982432 3482 688664 SGTC_2433 5607874 27.82 µM -0.539586899191174 0.289026583378774 no 2367 0.294740976695994 3370 2252428 SGTC_832 4083-0019 164 µM -0.541376756225298 0.28835917014471 no 2368 0.294123962460529 3460 1990758 SGTC_1442 4112-3290 3 µM -0.541944467310053 0.28814763032688 no 2369 0.293928381192978 3385 704353 SGTC_2116 5511452 16.8835 µM -0.542231296349604 0.288040780285857 no 2370 0.293829589039257 3445 870744 SGTC_2265 7929201 200 µM -0.542753816500872 0.287846178270809 no 2371 0.2936496575934 3303 1265108 SGTC_1886 st057356 49.9 µM -0.542979379355033 0.287762191160957 no 2372 0.293572000084542 3314 24207747 SGTC_1958 st076513 41.9 µM -0.543226731566741 0.287670104212596 no 2373 0.293486851798363 3334 732122 YGL099W LSG1 SGTC_1137 ixabepilone 100 µM -0.544185865661129 0.287313159192835 no 2374 0.29315678862762 3448 154225 A novel microtubule stabilizer. SGTC_1812 st052057 4.327 µM -0.544629714168178 0.287148050416393 no 2375 0.293004107006737 3381 3645418 SGTC_383 2324-0395 7.37 µM -0.545886616643349 0.286680734690669 no 2376 0.292571939263561 3452 3146421 SGTC_1733 st037357 54.9 µM -0.546481466086487 0.286459695750242 no 2377 0.292367512192794 3336 1272339 YGL099W LSG1 SGTC_1055 3448-0672 86 µM -0.547812070021868 0.285965552228152 no 2378 0.291910474974926 3434 748378 SGTC_2191 5911152 200 µM -0.54811578678249 0.285852818408073 no 2379 0.291806200689288 3391 2875902 SGTC_1809 st050081 57.6 µM -0.550377349315124 0.28501403513598 no 2380 0.291030290590645 3517 5036894 SGTC_2844 9010103 25.97 µM -0.550878199693566 0.28482843529425 no 2381 0.290858586361753 3470 2480525 SGTC_1396 3511-0007 98.6 µM -0.55115972969799 0.284724134203679 no 2382 0.290762091520893 3416 X1396 SGTC_1956 st077085 54 µM -0.551638488077537 0.284546805918539 no 2383 0.290598030733363 3408 24208685 SGTC_1297 1068-0111 14.1 µM -0.551838849118408 0.284472609446254 no 2384 0.290529383925673 3367 767057 SGTC_949 1165-0505 146 µM -0.552508105094776 0.284224841692647 no 2385 0.2903001414494 3366 6244267 SGTC_1253 0550-0034 176 µM -0.552872777727928 0.284089878315298 no 2386 0.290175264586299 3436 5969915 SGTC_2561 acetosyringone 100 µM -0.554043282965752 0.283656887853448 no 2387 0.289774612156319 3325 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.554225830319016 0.28358938888334 no 2388 0.289712151396186 3425 442882 SGTC_1966 st070145 16.1 µM -0.555655119687468 0.283061158988952 no 2389 0.289223321485975 3360 3748532 SGTC_815 1582-0027 36.9 µM -0.555766573341288 0.283019988339 no 2390 0.289185219628344 3452 3128206 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.557352643871489 0.282434410306346 no 2391 0.288643257043622 3409 2724278 An inhibitor of dopamine biosynthesis. SGTC_2222 6885208 172.143 µM -0.557454549894269 0.28239680648308 no 2392 0.288608451971567 3418 609514 SGTC_1626 st003712 1.76 µM -0.558141321663774 0.282143447147522 no 2393 0.288373942914866 3468 24207035 SGTC_2521 angolensin 13.4 µM -0.558778624534206 0.281908435485724 no 2394 0.288156406189021 3481 821428 A flavenoid. SGTC_117 lucigenin 22.078 µM -0.558787329570264 0.281905226071612 no 2395 0.288153435351298 3449 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_992 3909-8734 162 µM -0.558924539266123 0.28185464127372 no 2396 0.288106610603098 3390 4288319 SGTC_796 1234-0020 70.7 µM -0.559151063401143 0.281771138689637 no 2397 0.288029313898041 3435 46495034 SGTC_2937 9044753 11.33 µM -0.559677645275646 0.281577073245906 no 2398 0.28784966649181 3435 6465530 YGL099W LSG1 SGTC_2183 6420625 130.508 µM -0.559944631974417 0.281478703129882 no 2399 0.287758602173715 3482 2897619 SGTC_2481 5478948 45.16 µM -0.56054209123164 0.281258631887638 no 2400 0.287554868985434 3476 77792 SGTC_2940 9060638 45.86 µM -0.560786100228607 0.281168776246169 no 2401 0.287471681705693 3427 4027022 SGTC_2653 dihydrofissinolide 100 µM -0.561230856506764 0.281005031644859 no 2402 0.287320085166055 3458 6857746 SGTC_1364 1653-0028 37.6 µM -0.562894775816302 0.280392840403228 no 2403 0.286753268896537 3430 5718652 SGTC_3050 9093513 49.47 µM -0.562989224829807 0.280358109982883 no 2404 0.286721110622723 3469 25236664 SGTC_1299 1079-1439 3.74 µM -0.565209255793003 0.279542369406852 no 2405 0.285965720924645 3379 323161 SGTC_2470 5664817 21.68 µM -0.565554189987565 0.279415728371306 no 2406 0.285848438269697 3479 2859561 SGTC_2695 st077686 51.995 µM -0.56609024990584 0.279218971710858 no 2407 0.285666215488866 3416 2876092 SGTC_1431 4049-0260 9.09 µM -0.566646779080138 0.279014773240554 no 2408 0.285477093092575 3451 3854841 SGTC_1704 st028805 70.8 µM -0.567604119852077 0.278663681312816 no 2409 0.285151904527349 3439 2876101 SGTC_3347 9188721 44.724 µM -0.568347383389172 0.278391247766959 no 2410 0.284899555313091 3463 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_191 3914-0123 66.505 µM -0.568542221080323 0.278319854033208 no 2411 0.284833422596657 3350 3144412 SGTC_17 0960-0276 49.807 µM -0.568582132325821 0.278305230588315 no 2412 0.284819876639763 3472 6821114 SGTC_872 0588-0139 234 µM -0.568617794168398 0.278292164437737 no 2413 0.284807773198798 3470 2047100 SGTC_1457 k015-0032 57.3 µM -0.569337399605431 0.278028571957807 no 2414 0.284563595372292 3474 4302660 SGTC_1360 1598-0022 39.8 µM -0.569466890963973 0.277981152027396 no 2415 0.284519666744805 3466 761525 SGTC_1659 st012954 42.1 µM -0.570479765508933 0.277610372076177 no 2416 0.284176171148328 3484 24207262 SGTC_2735 sertaconazole 140 nM -0.571805065861112 0.277125588553236 no 2417 0.283727022462569 3489 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3026 9090633 49.47 µM -0.572199073663581 0.276981543797353 no 2418 0.283593557499982 3418 25236842 SGTC_1264 0783-0040 158 µM -0.57270059617792 0.276798245927167 no 2419 0.28342371686546 3403 2855798 SGTC_574 1315-0397 40 µM -0.572722620686825 0.276790197709392 no 2420 0.283416259381787 3500 6794277 SGTC_2242 6630449 61.2675 µM -0.572762343302201 0.276775682521905 no 2421 0.283402809569176 3464 691249 YDR170C SEC7 SGTC_2849 9019321 12.99 µM -0.574759772776461 0.27604627563778 no 2422 0.282726888133797 3456 16489627 SGTC_2291 7917025 104.35 µM -0.575919738222486 0.275623121484109 no 2423 0.28233471672643 3394 2964612 SGTC_2505 galangin 7.89 µM -0.576051345290195 0.275575131519486 no 2424 0.282290238378046 3411 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_572 0960-0087 17.7 µM -0.576200788713658 0.275520642585127 no 2425 0.28223973608579 3424 6796365 SGTC_1699 st031318 29.054 µM -0.576423991595164 0.275439269902163 no 2426 0.282164315925262 3485 5340658 SGTC_1787 fluconazole 80 µM -0.578564843275453 0.274659384457269 no 2427 0.281441416251499 3444 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2601 securinine 100 µM -0.579153774564296 0.274445035326364 no 2428 0.281242709142403 3396 442872 A GABA receptor antagonist. SGTC_93 0109-0045 59.227 µM -0.580315360201625 0.274022503413251 no 2429 0.280850985489305 3531 88733 SGTC_3161 9100388 49.47 µM -0.58209038059505 0.273377453483431 no 2430 0.280252902105113 3508 25236368 SGTC_3075 9116269 49.47 µM -0.582330824123986 0.273290133146087 no 2431 0.280171933448247 3532 17015205 YNL244C SUI1 SGTC_414 piperonyl butoxide 100 µM -0.583957428689057 0.272699772683288 no 2432 0.279624477011905 3393 5794 A potent inhibitor of cytochrome P450. SGTC_2776 terbinafine 19.92 µM -0.585600916366332 0.272103928092605 no 2433 0.279071866216671 3487 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1001 4048-4355 44.4 µM -0.585980693155958 0.271966332570862 no 2434 0.27894424460669 3487 21824233 SGTC_3304 9125678 46.087 µM -0.587526343867821 0.271406690867036 no 2435 0.278425131480387 3463 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2575 plumbagin 510 nM -0.588089733887863 0.271202844125996 no 2436 0.27823603176807 3439 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1611 st001856 99.4 µM -0.589151558531517 0.27081886053196 no 2437 0.277879804695177 3442 647478 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.591798601088966 0.269862803653851 no 2438 0.276992730038477 3490 2346 DNA damaging agent; causes G2/M arrest. SGTC_1719 st032227 49.2 µM -0.592211696085657 0.269713754870187 no 2439 0.276854419145783 3496 3125804 SGTC_2058 5236698 133 µM -0.5923839916124 0.269651601117404 no 2440 0.27679674181133 3455 766665 SGTC_2652 actinonin 100 µM -0.592993933482677 0.269431628843065 no 2441 0.276592606102593 3482 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_928 2764-0428 58.7 µM -0.593762516433323 0.269154571662554 no 2442 0.276335481426703 3506 662578 SGTC_2249 haloperidol 116.36 µM -0.593777297433752 0.269149244839544 no 2443 0.276330537683801 3515 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3285 9112818 20.8695 µM -0.594326682400913 0.268951293298905 no 2444 0.276146817844218 3515 17017947 YPR165W RHO1 SGTC_1027 k015-0025 8.67 µM -0.595609610399047 0.268489320145563 no 2445 0.275718027488579 3502 3598955 SGTC_122 0236-0016 402.397 µM -0.59586359035691 0.268397911116599 no 2446 0.275633179119149 3549 6808838 SGTC_1516 st013856 110 µM -0.596109772766147 0.26830932341506 no 2447 0.275550947970716 3491 5281404 A mutagen and neurotoxin. SGTC_3145 9085516 49.47 µM -0.596666084123044 0.268109191305935 no 2448 0.275365170361344 3491 25236195 SGTC_527 4476-4215 268 µM -0.597703725935489 0.267736102227645 no 2449 0.275018819447836 3404 4418754 SGTC_1199 1638-0010 4.46 µM -0.597730805752495 0.267726369053808 no 2450 0.275009783442471 3448 3111136 SGTC_1782 st039423 80.636 µM -0.597874902446167 0.267674580042126 no 2451 0.274961703653643 3424 2068169 SGTC_579 4491-1009 110 µM -0.598620447462287 0.267406708415814 no 2452 0.274713008757661 3626 1271041 SGTC_1111 tnp00062 510.699 nM -0.598872944309193 0.267316017873816 no 2453 0.274628807368176 3556 676306 SGTC_2556 citropten 84.59 µM -0.601752988396748 0.266282677415748 no 2454 0.273669286275551 3446 2775 A potential DNA crosslinker. SGTC_2635 hydroquinidine 100 µM -0.602683504479111 0.265949247150207 no 2455 0.273359628606122 3506 442912 An experimental heart treatment. SGTC_438 sphingosine 6.67 µM -0.60505406707929 0.265100764374565 no 2456 0.272571536355115 3363 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2833 9001315 45.46 µM -0.60666370374282 0.264525420551094 no 2457 0.272037057236997 3419 2989378 SGTC_2725 haloperidol 53.21 µM -0.606699722983306 0.264512553210434 no 2458 0.272025103028765 3500 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3203 9113543 49.47 µM -0.607251651133235 0.264315424884093 no 2459 0.271841959603393 3516 17018012 SGTC_2874 9043904 71.43 µM -0.608105324582309 0.264010671677753 no 2460 0.271558810502305 3447 4463428 SGTC_2881 9058953 51.95 µM -0.609056099636033 0.26367146503057 no 2461 0.271243627415004 3484 17122249 SGTC_413 propylparaben 100 µM -0.60997909222038 0.263342383095945 no 2462 0.270937828790705 3470 7175 A pharmaceutical preservative. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.610580119694784 0.263128206760983 no 2463 0.270738793627906 3552 7104 SGTC_248 streptozotocin 5.23457 mM -0.611634087266154 0.262752840076518 no 2464 0.270389939991867 3564 5300 DNA alkylating agent. SGTC_145 3737-0113 38.366 µM -0.611832985160632 0.262682034055506 no 2465 0.270324131814542 3576 6849351 SGTC_138 0850-0259 40.9225 µM -0.613005833678717 0.262264708186135 no 2466 0.26993624120559 3576 6813004 SGTC_931 2812-0076 566 µM -0.615436637111125 0.261400856375122 no 2467 0.269133201175977 3533 3450959 SGTC_2630 antimycin a 100 µM -0.616970885966542 0.260856372712831 no 2468 0.26862696461931 3514 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3137 9097352 49.47 µM -0.617012965950609 0.260841447333384 no 2469 0.268613086768002 3660 44120435 SGTC_1323 1348-1351 11.2 µM -0.617149039868524 0.260793186186043 no 2470 0.268568212468513 3472 6989654 SGTC_460 trequinsin 123 µM -0.618923269994413 0.260164343180039 no 2471 0.26798345398268 3573 5537 A vasodilator. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.619132629807079 0.260090191059124 no 2472 0.267914494575639 3539 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1300 1094-0077 113 µM -0.619710001672054 0.259885751035657 no 2473 0.267724364848425 3518 5532636 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.620420993553558 0.259634111807989 no 2474 0.267490327232447 3593 368090 SGTC_672 1441-0018 53.7 µM -0.622384040815509 0.258939990017394 no 2475 0.266844685927271 3522 251141 SGTC_908 3448-7491 47.7 µM -0.623565698201276 0.258522626327138 no 2476 0.266456421786429 3585 1203031 SGTC_654 1124-0271 80.9 µM -0.623961370289931 0.258382952078269 no 2477 0.266326477369264 3530 5403748 SGTC_2883 9059145 45.46 µM -0.624416198924205 0.258222443587582 no 2478 0.266177144720113 3533 16476510 SGTC_1369 1866-0067 208 µM -0.627226313875043 0.257231904689294 no 2479 0.265255448386249 3580 3531355 SGTC_2730 imipramine 71.33 µM -0.627800482271865 0.257029759071368 no 2480 0.265067325075955 3581 3696 A tricyclic antidepressant. SGTC_2193 5925765 200 µM -0.628134378861502 0.256912243183793 no 2481 0.264957956757956 3570 877370 SGTC_2982 9019404 25.97 µM -0.628461551231757 0.256797121029077 no 2482 0.264850813215273 3460 22333232 SGTC_143 4032-1194 15.74 µM -0.630493011261332 0.256082912522018 no 2483 0.264186036924582 3574 1806963 SGTC_800 3448-7362 155 µM -0.631263033878835 0.255812463634756 no 2484 0.263934276535037 3637 15991913 SGTC_728 3030-5151 22.5 µM -0.631390460116399 0.25576772311778 no 2485 0.263892626075414 3590 3125388 SGTC_2943 9068529 45.32 µM -0.633236154311663 0.255120141394266 no 2486 0.263289719612187 3600 3270634 SGTC_2100 5377183 190 µM -0.634584176262617 0.25464771579855 no 2487 0.262849825542107 3593 2844202 SGTC_2713 st079149 53.4 µM -0.63739946291277 0.253662554579129 no 2488 0.26193233906794 3566 3103253 SGTC_883 0850-0245 24.6 µM -0.638860870032145 0.253151950596827 no 2489 0.261456722790011 3608 6823229 YPR165W RHO1 SGTC_2068 5226020 147 µM -0.638938901709988 0.253124702162236 no 2490 0.261431339786296 3568 1810509 SGTC_1129 3453-1384 223 µM -0.639395111027762 0.252965426077973 no 2491 0.261282964324534 3635 1084452 SGTC_1534 6-azauridine 81.6 µM -0.639929410968276 0.252778953337877 no 2492 0.261109246041634 3585 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3275 9138069 49.47 µM -0.640731156751283 0.252499276804801 no 2493 0.260848683844417 3588 17617007 SGTC_290 2043-6722 48.1 µM -0.641390992796265 0.252269225646969 no 2494 0.260634341775277 3576 773758 YLR208W SEC13 SGTC_302 1094-0063 18.9 µM -0.64162450712068 0.252187837602159 no 2495 0.260558508378178 3537 5440289 SGTC_2146 5545642 200 µM -0.64186325023553 0.252104641456772 no 2496 0.260480988685503 3604 825326 SGTC_1724 st037281 8.293 µM -0.641960377967039 0.252070798957905 no 2497 0.26044945479016 3597 574124 YDL195W SEC31 SGTC_1161 k007-0610 110 µM -0.64206058363588 0.252035886516364 no 2498 0.260416923659409 3630 5843850 SGTC_2334 9017922 200 µM -0.642166497117065 0.251998988201767 no 2499 0.260382541798961 3582 3163164 SGTC_2781 5567276 71.43 µM -0.642191308404317 0.251990344816383 no 2500 0.260374487843954 3595 2853274 SGTC_251 melphalan 456.522 µM -0.64322611905776 0.251629992316857 no 2501 0.26003869382247 3633 460612 A DNA alkylator. SGTC_1737 st035557 69.7 µM -0.645084473200148 0.250983540925399 no 2502 0.259436222621419 3511 5716916 SGTC_2885 9057732 51.95 µM -0.645612940854434 0.250799867564304 no 2503 0.259265027223206 3608 6471414 SGTC_781 4335-2806 94.4 µM -0.645851382868623 0.250717018349099 no 2504 0.259187803816507 3646 845254 SGTC_1116 jasmonic acid  1.58368 µM -0.647617073867212 0.250103961540338 no 2505 0.258616325692944 3635 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2731 amoxapine 43.43 µM -0.648159594114745 0.249915755608251 no 2506 0.258440866373082 3622 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1802 st050112 57.9 µM -0.64868602604373 0.249733202765531 no 2507 0.258270669231195 3589 4662563 SGTC_1259 0671-0132 43 µM -0.64932373792981 0.249512155821362 no 2508 0.258064572756958 3525 X1259 SGTC_1197 1601-0112 267 µM -0.649575227292616 0.249425011888898 no 2509 0.257983319586321 3578 7350313 SGTC_2268 7933382 153.85 µM -0.649869170751587 0.249323177634048 no 2510 0.257888366833498 3627 935025 YOR257W CDC31 SGTC_469 w7 172 µM -0.650280340907536 0.24918076826172 no 2511 0.257755576691518 3616 45115570 A P450 inhibitor. SGTC_356 1634-0012 32.5 µM -0.650875486384919 0.248974715425015 no 2512 0.257563433377093 3595 735457 SGTC_1662 st014054 52 µM -0.652446676292556 0.24843116986858 no 2513 0.257056530794986 3595 2838777 SGTC_194 1486-1323 56.904 µM -0.65268801381039 0.24834773638667 no 2514 0.256978715668654 3578 5178754 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.652992277280845 0.248242569884446 no 2515 0.256880628619415 3611 5106787 A p450 inhibitor. SGTC_2666 tannic acid 100 µM -0.654982896964501 0.247555112667399 no 2516 0.256239382876127 3627 16134267 A thiamine antagonist. SGTC_377 3970-0964 33.1 µM -0.655593647354211 0.247344395110118 no 2517 0.256042807009533 3603 16481235 SGTC_2734 clemastine 41.6 µM -0.656366121305017 0.247078018009527 no 2518 0.255794291579605 3574 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2381 9035592 200 µM -0.657046514424874 0.246843520899348 no 2519 0.255575504151519 3561 4749657 SGTC_1666 st014829 29 µM -0.657917229176626 0.246543603409002 no 2520 0.255295659489398 3618 3858230 SGTC_2900 5328528 85.29 µM -0.659016306232837 0.246165305487869 no 2521 0.2549426488265 3626 795359 SGTC_2241 6772625 37.8075 µM -0.659692112944724 0.245932850167844 no 2522 0.254725714519457 3570 2285411 SGTC_2040 5100729 123 µM -0.659846894370565 0.245879627022926 no 2523 0.254676043207954 3621 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2144 5628481 200 µM -0.661276064734081 0.245388484662373 no 2524 0.254217644166555 3600 2818399 SGTC_91 0417-1751 58.384 µM -0.661546303885485 0.24529567478061 no 2525 0.254131015013384 3687 6795624 SGTC_2705 st078069 42.8 µM -0.664107628720655 0.24441696107908 no 2526 0.253310713938586 3579 1530061 SGTC_768 0384-0033 77.3 µM -0.665215688177868 0.244037345398977 no 2527 0.252956273822838 3606 3965305 YMR134W ERG29 SGTC_755 1995-0008 37.3 µM -0.665618552390296 0.243899404991077 no 2528 0.252827472503832 3622 689533 SGTC_2149 5554786 194.827 µM -0.66635657860332 0.243646814536992 no 2529 0.252591604798212 3651 745063 YPR165W RHO1 SGTC_2140 5586273 200 µM -0.666384111962232 0.243637393942138 no 2530 0.252582807584312 3609 854421 SGTC_2414 st077232 92.9 µM -0.666729268275623 0.243519314695492 no 2531 0.252472540005108 3589 729801 SGTC_441 propafenone 146 µM -0.667332138493096 0.243313144743492 no 2532 0.252280001064094 3605 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1845 st056753 3.01 µM -0.667449016396542 0.243273185681596 no 2533 0.252242682675213 3578 5375839 SGTC_1984 st072354 53.1 µM -0.667503077761214 0.243254703991599 no 2534 0.252225422201789 3565 5762938 SGTC_2455 5377712 9.75 µM -0.667672468988482 0.243196799969762 no 2535 0.252171343753289 3576 2243908 SGTC_215 1287-0124 461.5 µM -0.668122658932363 0.243042945059821 no 2536 0.252027649546829 3629 5560863 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.668233385089994 0.243005111849231 no 2537 0.251992313958052 3608 803109 SGTC_1053 3366-3204 134 µM -0.669081599192179 0.242715397478129 no 2538 0.251721713580158 3590 3632071 YPR165W RHO1 SGTC_956 1185-0240 191 µM -0.669134032154332 0.242697494715137 no 2539 0.251704991261487 3633 1416193 SGTC_1879 gemcitabine 100 µM -0.669245276281845 0.242659513776491 no 2540 0.25166951438197 3630 60750 A nucleoside analog which inhibits DNA replication. SGTC_1355 1499-0035 1.68 µM -0.669697940350244 0.242504998532316 no 2541 0.251525182465247 3631 1548538 SGTC_389 tpck 16.7 µM -0.670142188089367 0.242353408000693 no 2542 0.251383576629422 3606 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3222 9128301 49.47 µM -0.670364542236148 0.242277553443312 no 2543 0.251312716137224 3646 4911358 SGTC_1900 st060200 72.8 µM -0.671157564870544 0.242007124146048 no 2544 0.251060079302691 3644 688945 SGTC_2333 9017922 200 µM -0.671864081470514 0.241766332309242 no 2545 0.250835114319356 3651 3163164 SGTC_1014 4130-3005 69.3 µM -0.672311641491497 0.241613864197225 no 2546 0.250692660044607 3655 743608 SGTC_839 0122-0028 230 µM -0.673222882882368 0.241303597406496 no 2547 0.250402752694659 3639 759448 SGTC_1278 0874-0585 172 µM -0.674050219252881 0.241022086892417 no 2548 0.25013969333788 3638 766306 SGTC_3006 9075424 71.4286 µM -0.677571421335833 0.239825958275863 no 2549 0.249021735696834 3633 7465181 SGTC_516 3992-2719 87.3 µM -0.677609480960785 0.239813047392007 no 2550 0.249009666565485 3597 5350887 YDR037W KRS1 SGTC_526 4469-0568 170 µM -0.678078848979269 0.239653855876452 no 2551 0.24886085032579 3645 2901964 SGTC_3148 9097893 49.47 µM -0.679587121242681 0.239142698802678 no 2552 0.248382963287425 3583 17174100 SGTC_3032 9089427 49.47 µM -0.680507627763481 0.238831029973367 no 2553 0.248091546845329 3616 17173707 SGTC_1661 st013063 9.66 µM -0.682237796403573 0.238245824191895 no 2554 0.247544299340921 3679 721395 SGTC_698 k064-0052 127 µM -0.682397520730929 0.238191839266311 no 2555 0.247493811519468 3696 5088751 SGTC_353 1988-1175 58.3 µM -0.682682731517724 0.23809545807906 no 2556 0.247403671930008 3524 2788357 SGTC_618 k072-0232 33.2 µM -0.683585772054373 0.237790434903547 no 2557 0.247118385786417 3637 5872756 YGL099W LSG1 SGTC_1852 st056254 31.4 µM -0.684353487455485 0.237531289621396 no 2558 0.246875989648953 3605 442583 SGTC_2419 paclitaxel 166.5 µM -0.684390636227983 0.237518753843506 no 2559 0.246864263636787 3611 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_318 1488-0629 67.2 µM -0.684818882055334 0.237374269382122 no 2560 0.246729109346306 3661 3662576 SGTC_2400 5203494 178.7 µM -0.684857711072046 0.237361171373569 no 2561 0.246716856876407 3622 6777674 SGTC_1518 st038567 90.8 µM -0.686570955709162 0.236783645889706 no 2562 0.246176568175116 3652 77966 SGTC_1905 st060207 84.5 µM -0.686743139926169 0.236725646287772 no 2563 0.246122303283843 3595 1948547 SGTC_1761 st044296 37 µM -0.687783564439449 0.236375349540638 no 2564 0.245794543792911 3665 1826700 SGTC_1429 4049-0205 9.46 µM -0.689191987431908 0.235901607679704 no 2565 0.245351229214686 3687 22774478 SGTC_2232 chlorophetanol 41.5365 µM -0.689362301032159 0.235844355918924 no 2566 0.245297650524364 3721 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2428 5615643 7.78 µM -0.689376700609533 0.23583951578084 no 2567 0.245293120872119 3669 2253075 SGTC_2508 celastrol 40.54 µM -0.689592596537784 0.235766953126314 no 2568 0.245225212223225 3617 122724 Celastrol is a natural product and antioxidant. SGTC_1409 3909-8004 61.9 µM -0.692848405491632 0.234674169181336 no 2569 0.244202345583068 3680 2119279 SGTC_995 3931-2021 34.6 µM -0.695673595933538 0.233728192713208 no 2570 0.243316632397089 3668 730143 SGTC_920 mycophenolic acid 780.421 nM -0.696271825781287 0.233528155137971 no 2571 0.243129306944396 3678 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1113 artemisinin 1.17947 µM -0.697206762286096 0.233215718998707 no 2572 0.242836703797399 3690 2240 An anti-malaria and mitochondrial poison. SGTC_3079 9117512 49.47 µM -0.698385624780555 0.232822098846834 no 2573 0.242468031952922 3690 7185044 SGTC_432 NS 1619 61.3 µM -0.699084141940843 0.232589039442912 no 2574 0.242249724155116 3680 4552 A K+/calcium channel activator. SGTC_717 1532-0246 73.2 µM -0.700723664458358 0.232042524563832 no 2575 0.241737742393084 3677 9561992 SGTC_1519 esterone 74 µM -0.701852970847848 0.231666500225257 no 2576 0.241385430199475 3669 698 A steroid. SGTC_628 1636-0253 16 µM -0.702619526999522 0.231411454171653 no 2577 0.241146445021635 3676 4456143 SGTC_2085 5307070 144.047 µM -0.704216284266648 0.230880689424997 no 2578 0.240649045692924 3647 2840351 SGTC_2893 9048488 25.97 µM -0.70456936765297 0.230763415767945 no 2579 0.240539133578303 3655 6467338 SGTC_557 1315-0110 16.2 µM -0.704897629526274 0.230654416218627 no 2580 0.240436972731919 3691 6833801 SGTC_2424 5537928 59.2 µM -0.705966891945598 0.230299566528589 no 2581 0.240104363451955 3753 5382802 SGTC_2533 agelasine 13.65 µM -0.70713680270648 0.229911665267322 no 2582 0.239740733609502 3717 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_3335 9143315 29.6265 µM -0.708648118925192 0.229411107799062 no 2583 0.239271433822271 3682 4899691 SGTC_3189 9110682 49.47 µM -0.708712042261601 0.229389949459233 no 2584 0.239251595168701 3744 17122418 SGTC_2043 5101342 149 µM -0.710261400526503 0.22887745343195 no 2585 0.238771025689946 3698 678451 SGTC_1152 3909-8331 15.9 µM -0.710977915437741 0.228640662437795 no 2586 0.238548960638091 3675 16001939 SGTC_1827 berberine 7.24 µM -0.712660074145368 0.228085290308879 no 2587 0.238028064088633 3649 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2810 7959871 45.46 µM -0.713294281746706 0.227876100959889 no 2588 0.237831837593755 3705 2974535 SGTC_1550 gossypolone 36.6 µM -0.713915253134862 0.227671382128801 no 2589 0.237639792427764 3698 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2001 4023502 57.655 µM -0.715164101867219 0.227259981399984 no 2590 0.237253824085433 3704 108941 YCR052W RSC6 SGTC_2526 patulin 37.61 µM -0.715538460673867 0.227136740290297 no 2591 0.237138192118368 3742 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1438 4092-1045 4 µM -0.716872966169786 0.22669771993135 no 2592 0.236726242026464 3695 1351342 SGTC_1766 st045414 44.774 µM -0.716980594485003 0.226662333672252 no 2593 0.236693035274487 3743 253960 SGTC_1181 1222-0449 220 µM -0.717768491895716 0.22640338210116 no 2594 0.236450021961313 3736 658318 SGTC_2427 5545055 42.75 µM -0.718558368313119 0.226143947894724 no 2595 0.236206536167888 3705 5372858 SGTC_634 1611-4317 11.2 µM -0.720257318903306 0.225586498767262 no 2596 0.235683289169101 3725 2843522 SGTC_476 mead acid 10 µM -0.720427402859663 0.225530734727585 no 2597 0.235630941517128 3725 5312531 An omega 9 fatty acid. SGTC_1273 0849-0096 14.1 µM -0.721131460679346 0.2252999840407 no 2598 0.235414318099086 3724 5286025 SGTC_756 0508-1999 28.3 µM -0.721754706066709 0.225095830747695 no 2599 0.235222650672063 3691 6753853 SGTC_2471 5466956 24.79 µM -0.723030315329045 0.224678312941248 no 2600 0.234830629769635 3678 724419 SGTC_1236 0330-0013 258 µM -0.723316316961649 0.22458476248121 no 2601 0.234742785185671 3711 4617066 SGTC_298 1391-0729 10 µM -0.723383155396886 0.224562902972574 no 2602 0.234722258570621 3687 3237558 SGTC_1065 prochlorperazine maleate 2.48 µM -0.726446054592122 0.2235624778152 no 2603 0.233782683345583 3753 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2475 5812728 15.03 µM -0.726828022416323 0.223437894878243 no 2604 0.233665657226925 3707 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_854 0422-0053 192 µM -0.727357894232468 0.22326513687268 no 2605 0.233503370531295 3743 3596728 SGTC_2818 7996756 12.99 µM -0.727648312434749 0.223170481953056 no 2606 0.23341444911262 3726 2241621 SGTC_3333 9141820 12.094 µM -0.729325076730643 0.22262442736869 no 2607 0.232901418159599 3724 1939433 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.730101228541302 0.22237192409633 no 2608 0.232664155227141 3779 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3074 9116018 49.47 µM -0.730831580904008 0.222134469889665 no 2609 0.23244101553923 3767 17027303 SGTC_2887 9044784 58.44 µM -0.733192488249729 0.221367875884877 no 2610 0.231720518113694 3727 6465546 SGTC_1444 4112-3581 28 µM -0.733382318780516 0.22130630309617 no 2611 0.231662640076535 3755 2877249 SGTC_3011 9081274 71.4286 µM -0.734238754916146 0.221028634178017 no 2612 0.231401618714376 3728 6625322 SGTC_1020 4335-0961 93.3 µM -0.734978973972371 0.220788805227244 no 2613 0.23117614974785 3688 669075 SGTC_960 1222-0186 7.7 µM -0.736045434858645 0.220443536961068 no 2614 0.230851523924591 3754 3126296 SGTC_2813 7971799 71.43 µM -0.737170830211707 0.220079524373704 no 2615 0.23050923494493 3784 2234054 SGTC_2274 7947094 46.08 µM -0.737567574437669 0.219951278484944 no 2616 0.230388632856699 3725 2971028 SGTC_1460 k062-0059 9.15 µM -0.738641822758245 0.219604247601154 no 2617 0.230062260596883 3652 1373085 SGTC_1470 k295-0292 231 µM -0.739398583790755 0.219359968393715 no 2618 0.229832500995222 3794 5045612 SGTC_676 falcarinol 140 µM -0.740009829416934 0.219162774979309 no 2619 0.229647015035873 3761 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2330 7979373 200 µM -0.741871920057424 0.218562676077201 no 2620 0.229082470176734 3707 1863007 SGTC_2975 9084847 53.72 µM -0.742067575331716 0.218499676913275 no 2621 0.229023197038712 3800 27211724 SGTC_2431 5490079 200 µM -0.743482107032319 0.21804452215561 no 2622 0.228594925256707 3794 5722345 SGTC_2465 5809242 33.21 µM -0.74396425795061 0.217889505141496 no 2623 0.228449049314453 3744 2731748 SGTC_3212 9128307 49.47 µM -0.744492370176299 0.217719783998415 no 2624 0.228289327701678 3730 27243542 SGTC_3037 9091026 49.47 µM -0.744808933366089 0.217618085628986 no 2625 0.228193616815823 3752 25236398 YIL048W NEO1 SGTC_1867 st057372 64 µM -0.744853317172657 0.217603829179852 no 2626 0.228180199455027 3732 688837 SGTC_339 3091-4833 71.4 µM -0.745100914770775 0.217524308655231 no 2627 0.228105358081498 3680 3240077 SGTC_3279 9140807 49.47 µM -0.746931253134267 0.216936982345403 no 2628 0.227552529743963 3785 45595718 SGTC_2826 7992541 19.48 µM -0.746958733270872 0.216928171398989 no 2629 0.227544235502339 3799 2985066 SGTC_1289 0976-0073 69.1 µM -0.747036827575279 0.216903133179206 no 2630 0.227520665477944 3781 3391136 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.748224554715756 0.216522535788844 no 2631 0.227162361255283 3811 6708561 SGTC_2688 kanamycin b 96.69 µM -0.749052126686714 0.216257575726418 no 2632 0.226912893954128 3862 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3233 9132340 49.47 µM -0.74924968929713 0.216194350744888 no 2633 0.226853362579784 3762 17682950 SGTC_2154 5570129 200 µM -0.749965212693338 0.215965454944586 no 2634 0.226637828273726 3770 673366 SGTC_510 ag-490 170 µM -0.75057943954142 0.215769075935631 no 2635 0.226452899360651 3876 5328779 SGTC_1373 2887-0003 58.5 µM -0.750678460626778 0.215737426863017 no 2636 0.226423094473836 3755 776948 SGTC_2168 5727979 200 µM -0.750885079641015 0.215671396057788 no 2637 0.226360910244537 3692 695210 SGTC_400 oxethazaine 37.5 µM -0.752822295747781 0.215052875397325 no 2638 0.225778353474535 3771 4621 A local anesthetic. SGTC_2086 5274770 176.623 µM -0.753122354079566 0.214957164001987 no 2639 0.22568819628483 3806 689278 SGTC_2528 xanthyletin 44.79 µM -0.753501386772328 0.214836297053555 no 2640 0.225574339140907 3816 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2757 clomiphene 4.22 µM -0.753948953887229 0.214693626514214 no 2641 0.225439936893343 3806 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2195 6536160 144.242 µM -0.754445533050748 0.21453539690367 no 2642 0.225290869630098 3684 3834386 SGTC_1868 st057644 42.7 µM -0.754788959587289 0.214426007397348 no 2643 0.225187809655974 3764 688665 SGTC_1304 1165-0502 251 µM -0.755647824077355 0.21415258069065 no 2644 0.224930187190704 3782 767425 SGTC_871 0574-0004 149 µM -0.756356957936414 0.213926974970834 no 2645 0.224717603455509 3756 9551173 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.756665584175011 0.213828831034736 no 2646 0.224625119259643 3726 5355888 SGTC_785 1270-0111 65.3 µM -0.756955720021711 0.213736591005673 no 2647 0.224538195662946 3749 6741994 SGTC_3057 9095946 49.47 µM -0.758068990741152 0.213382874964002 no 2648 0.224204841153643 3777 24540043 SGTC_2385 9074692 200 µM -0.75860192270014 0.213213668998333 no 2649 0.224045361095252 3775 17046906 SGTC_2969 9091408 28.7 µM -0.760597459889731 0.212580781133169 no 2650 0.223448768707782 3740 4286311 SGTC_1288 0973-0013 65.5 µM -0.761122938591987 0.212414307392162 no 2651 0.223291820321497 3824 4315430 SGTC_2450 5739737 12.93 µM -0.762891645528069 0.211854533974568 no 2652 0.222764009530256 3795 2262825 SGTC_24 0417-1663 219 µM -0.762913066185357 0.21184775990067 no 2653 0.222757621619787 3733 4329390 SGTC_2675 theaflavin digallate 100 µM -0.763185380755804 0.211761654120679 no 2654 0.22267642307596 3749 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1721 st082152 9.2685 µM -0.764215155117378 0.211436225008859 no 2655 0.222369518341094 3717 5296051 SGTC_625 k213-0058 121 µM -0.76633630838866 0.210766822240788 no 2656 0.221738109781886 3839 3655420 SGTC_2663 amphotericin b 100 µM -0.767064014890466 0.21053745615931 no 2657 0.221521727925865 3774 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2131 toluylene red 5.2905 µM -0.767087353731133 0.21053010240667 no 2658 0.221514790173411 3792 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_18 0111-0177 500 nM -0.767215759239287 0.21048964626614 no 2659 0.221476622305788 3853 721752 SGTC_2259 7964009 200 µM -0.768153658079612 0.210194285147906 no 2660 0.221197950813011 3800 313134 SGTC_433 pimozide 108 µM -0.768650833469122 0.210037814496716 no 2661 0.221050309862354 3713 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1801 st050089 28.441 µM -0.769752515110886 0.209691338048875 no 2662 0.220723356056331 3806 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1240 0356-0016 42.1 µM -0.769952328938886 0.209628533065803 no 2663 0.220664085588837 3791 4305613 SGTC_2192 5915882 198.485 µM -0.770208443659025 0.209548047906986 no 2664 0.220588128008223 3752 2876149 SGTC_1439 4092-1168 46 µM -0.771078297647529 0.209274828268302 no 2665 0.220330261711746 3782 2886240 SGTC_2552 juarezic acid 87.02 µM -0.77177709862734 0.209055488048903 no 2666 0.220123228941268 3822 1549512 SGTC_1664 st014217 9.02 µM -0.771892363176623 0.209019321730046 no 2667 0.220089090401122 3833 3982782 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.772404510124572 0.208858671009721 no 2668 0.219937441733254 3828 1377 SGTC_2137 5261020 140 µM -0.772537622201825 0.208816928206499 no 2669 0.21989803655829 3758 763655 SGTC_268 camptothecin 39.6153 µM -0.773948075473177 0.208374924273415 no 2670 0.219480748995738 3785 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_92 0063-0024 660.874 µM -0.773998906895068 0.20835900517263 no 2671 0.219465718838147 3867 3594437 SGTC_2171 5739187 198.077 µM -0.774067482069048 0.208337530319395 no 2672 0.21944544303225 3729 2262761 SGTC_1738 st035555 74 µM -0.774391151561153 0.208236188306691 no 2673 0.219349757332768 3821 5331140 SGTC_3245 9134821 49.47 µM -0.779876455746844 0.206523148666822 no 2674 0.217731799032694 3807 17014901 SGTC_2464 5717415 7.67 µM -0.780349427974857 0.206375833194436 no 2675 0.217592613190504 3791 5285744 SGTC_348 k064-0012 10.7 µM -0.781800282914434 0.205924327687215 no 2676 0.217165977381555 3729 5066323 SGTC_1213 1315-0166 115 µM -0.783073853303432 0.205528476407554 no 2677 0.216791872151064 3875 768401 SGTC_3143 9086658 49.47 µM -0.78323613062596 0.205478069825096 no 2678 0.216744230741363 3888 25236626 SGTC_1204 4049-0315 18.3 µM -0.784611582836895 0.20505112173047 no 2679 0.216340668404338 3914 588402 SGTC_387 norethindrone acetate 66.7 µM -0.784704009812125 0.205022450797267 no 2680 0.216313565621408 3814 541197 SGTC_892 0929-0076 29 µM -0.785496881693126 0.204776599120944 no 2681 0.216081148952392 3800 5751038 SGTC_522 1273-0010 11.6 µM -0.787262960817071 0.204229608492916 no 2682 0.215563973640741 3910 5705015 SGTC_159 3970-0959 50 µM -0.788601704255771 0.203815552766238 no 2683 0.21517241727501 3889 6615653 SGTC_601 0986-0029 62.9 µM -0.792727881446398 0.202542531981398 no 2684 0.21396819113621 3795 24747981 SGTC_2418 pentamidine 31.67 µM -0.795223410030825 0.201774915894061 no 2685 0.213241778261512 3785 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2106 5357045 167.29 µM -0.796055342767045 0.201519403915838 no 2686 0.21299993446731 3864 668842 SGTC_1440 4100-1550 40 µM -0.797916166626833 0.200948590261982 no 2687 0.212459570529436 3833 742806 SGTC_2161 5662504 8.5105 µM -0.798569394175581 0.20074844088557 no 2688 0.212270070111995 3805 2859334 SGTC_1047 2043-3044 82 µM -0.799154661413599 0.200569216266818 no 2689 0.212100368825713 3843 669592 SGTC_6 0844-0013 19.835 µM -0.79932333240227 0.200517582499711 no 2690 0.212051476522572 3933 1584900 SGTC_2621 lithochol-11-enic acid 100 µM -0.800386805866205 0.200192214588726 no 2691 0.211743361529722 3777 6708711 SGTC_3273 9137859 49.47 µM -0.801590757830295 0.199824250699399 no 2692 0.211394862774296 3901 2377234 SGTC_2028 5153890 36.43 µM -0.802950355801334 0.199409206170118 no 2693 0.21100171453433 3799 2830968 YPR165W RHO1 SGTC_1250 0485-0349 40.2 µM -0.805872466159225 0.198518931632028 no 2694 0.210158194340938 3844 6842794 YDL195W SEC31 SGTC_230 MPP+ 141.667 µM -0.805997391451751 0.198480924370057 no 2695 0.210122176593165 3831 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2720 fluspirilene 36.88 µM -0.806090987338928 0.198452451640909 no 2696 0.210095193937113 3821 3396 An atypical antipsychotic. SGTC_88 0180-0332 8.668 µM -0.806521743107962 0.198321443548999 no 2697 0.209971038071737 3906 3101745 SGTC_499 genistein 192 µM -0.807454134361663 0.19803804915033 no 2698 0.209702444536822 3843 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_448 monastrol 171 µM -0.808934168098777 0.19758870480726 no 2699 0.209276507001873 3758 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1287 0971-0001 34.6 µM -0.809214409681443 0.19750369175757 no 2700 0.209195913913825 3828 4665869 SGTC_1048 3161-0300 24.5 µM -0.809373429474261 0.197455461937856 no 2701 0.209150190439843 3843 2165101 SGTC_205 1486-1330 71.903 µM -0.809924525557344 0.197288372671897 no 2702 0.208991777541903 3825 4118834 SGTC_2005 4024620 188 µM -0.810188571337872 0.197208345776371 no 2703 0.208915902472873 3825 236743 SGTC_2484 5809818 12.04 µM -0.811938505273007 0.196678473012611 no 2704 0.208413459218767 3849 2870548 SGTC_1781 st038725 66.3 µM -0.813908748287487 0.196082924743505 no 2705 0.207848614323291 3847 4270275 YIL048W NEO1 SGTC_1862 st057513 3.81 µM -0.813962901378093 0.196066571268308 no 2706 0.207833102062189 3827 5393163 SGTC_89 0302-0250 142.109 µM -0.816112953843181 0.195417954155942 no 2707 0.207217767875261 3922 4203518 YLR208W SEC13 SGTC_735 3076-0345 636 µM -0.81623701176675 0.195380568793767 no 2708 0.207182296031532 3909 2888990 SGTC_2506 ethyl hematommate 54.16 µM -0.81627594068415 0.195368838301089 no 2709 0.207171165838577 3940 3940691 An allergen. SGTC_885 0865-0106 16.8 µM -0.816544479870179 0.19528793075421 no 2710 0.207094397254297 3783 2793380 SGTC_2939 9044578 71.43 µM -0.817360983171263 0.195042053454501 no 2711 0.206861082940639 3819 2653634 SGTC_2173 5763948 167 µM -0.817435879008785 0.195019509162152 no 2712 0.206839689386155 3852 2867177 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.817943338979852 0.194866801073913 no 2713 0.206694770939407 3819 15053 SGTC_2729 fluphenazine 10.66 µM -0.81829978564181 0.194759580365692 no 2714 0.206593014243203 3787 3372 An atypical antipsychotic. SGTC_711 k292-0785 179 µM -0.818427730716527 0.194721102684354 no 2715 0.206556496329949 3837 4146315 SGTC_2353 9059630 146.67 µM -0.819466739501089 0.194408806705076 no 2716 0.206260085446682 3911 4779114 SGTC_2931 9014674 55.67 µM -0.820135331074659 0.194208008750011 no 2717 0.206069481449463 3875 2996810 SGTC_2260 7964312 200 µM -0.820633465791758 0.194058486208951 no 2718 0.205927539702678 3908 231951 SGTC_2204 7233102 200 µM -0.821232074865454 0.193878897606506 no 2719 0.205757044883753 3764 2172480 SGTC_830 4076-0286 57.8 µM -0.825951398250218 0.192466604324767 no 2720 0.204415831207435 3927 6866659 SGTC_2147 5545932 89.7195 µM -0.826315264265946 0.192357976452967 no 2721 0.204312638412328 3900 797404 SGTC_209 4077-0173 175.592 µM -0.827864927713367 0.191895762856482 no 2722 0.203873499638168 3828 15993494 SGTC_15 0266-0086 27.098 µM -0.827912365340193 0.191881624506748 no 2723 0.203860065791542 3943 1712902 YIL048W NEO1 SGTC_3280 9140961 49.47 µM -0.829778429724082 0.191325967145835 no 2724 0.203332034281846 3913 4901226 SGTC_879 0831-1030 162 µM -0.830121372201911 0.191223956661209 no 2725 0.203235082304579 3919 1549252 SGTC_1037 k284-1091 78.7 µM -0.830542057661437 0.191098866565093 no 2726 0.203116189591757 3833 3334711 SGTC_2778 tioconazole 65.09 nM -0.830770202084616 0.19103104920388 no 2727 0.203051729549852 3803 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1702 st027038 51 µM -0.832296052566598 0.190577860150244 no 2728 0.202620929098652 3910 5521182 SGTC_770 0389-1121 67.2 µM -0.832559991657141 0.190499535269407 no 2729 0.202546465409042 4013 6753108 SGTC_682 0kpi-0099 17 µM -0.832873453948999 0.190406539879265 no 2730 0.202458051264143 3927 1714895 YML126C ERG13 SGTC_2680 butyl paraben 22.24 µM -0.834770876502254 0.189844223650608 no 2731 0.2019233632569 3932 7184 An antifungal and steroid mimetic. SGTC_1914 st062367 72.6 µM -0.835981706826759 0.189485918765927 no 2732 0.201582597164508 3899 978205 SGTC_573 3702-0553 84.7 µM -0.837182763691372 0.189130917419837 no 2733 0.201244922230418 3837 1222756 SGTC_272 doxorubicin 8.13 µM -0.839291917594015 0.18850849804659 no 2734 0.200652758810412 3866 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2105 5350118 200 µM -0.839417033495862 0.188471615596162 no 2735 0.200617664324512 3883 2133313 SGTC_1723 st034307 2.5525 µM -0.839478055032616 0.188453628899408 no 2736 0.200600549376398 3946 867466 SGTC_1336 1486-0901 104 µM -0.839659253589733 0.188400225086007 no 2737 0.20054973307817 3902 5006114 SGTC_273 hydroxyurea 18.1 mM -0.842198555371794 0.187652810715316 no 2738 0.199838411149552 3956 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2108 5365811 200 µM -0.842832110861533 0.187466616842994 no 2739 0.199661173230232 3935 780283 SGTC_3274 9138298 49.47 µM -0.843320952286014 0.187323030654716 no 2740 0.199524483912549 3851 17015756 SGTC_3169 9102970 49.47 µM -0.843393909640941 0.187301606902876 no 2741 0.199504088486143 3965 17027839 SGTC_1745 st081495 74 µM -0.845917470219972 0.186561502060843 no 2742 0.198799392922493 3815 13842402 YBL026W LSM2 SGTC_2008 4012253 172 µM -0.84888118437129 0.185694625718904 no 2743 0.197973704825835 3914 603940 SGTC_3066 9117245 49.47 µM -0.848905193640983 0.185687613308662 no 2744 0.19796702433384 3964 17176980 SGTC_575 k072-0246 11.9 µM -0.849011141702073 0.185656670919782 no 2745 0.19793754629719 3938 6796779 SGTC_2723 salbutamol 83.58 µM -0.849127021812096 0.185622831515104 no 2746 0.197905307892432 3901 9884233 β2-adrenoceptor agonist SGTC_849 0386-0493 241 µM -0.85035614244986 0.185264138317505 no 2747 0.197563555889931 3852 726119 SGTC_3239 9133757 49.47 µM -0.851112316004115 0.18504367885152 no 2748 0.197353482275379 3909 17036923 SGTC_1919 st067113 52.3 µM -0.853499032548026 0.184348910566807 no 2749 0.196691311964515 3968 1268243 SGTC_2090 5301565 104.445 µM -0.853981999779275 0.184208517491408 no 2750 0.19655748149624 3910 2056344 SGTC_3283 9109332 35.8195 µM -0.857481882801599 0.183193130654531 no 2751 0.19558931160708 3755 17027281 SGTC_583 1488-1091 88.9 µM -0.858126303235884 0.183006552521491 no 2752 0.195411362268941 4029 4303273 SGTC_723 4182-0001 115 µM -0.858396714052969 0.182928296189387 no 2753 0.195336720712813 3914 744821 YLR208W SEC13 SGTC_2224 6650123 117.647 µM -0.859290121240139 0.182669894499623 no 2754 0.195090236510444 3869 2908370 SGTC_3035 9091303 49.47 µM -0.860251149242048 0.182392189304988 no 2755 0.194825307413629 3959 25237002 SGTC_25 0118-0223 35.662 µM -0.862813482865027 0.181653049982871 no 2756 0.194120012435358 3920 5333628 SGTC_2789 5281112 71.43 µM -0.863268384952117 0.181522023589533 no 2757 0.19399496116196 3961 765948 SGTC_2244 6635614 200 µM -0.863532111688253 0.181446088925002 no 2758 0.193922485924711 3843 836499 SGTC_1759 st043059 70 µM -0.86453167865704 0.181158464821313 no 2759 0.193647942882114 3942 669426 SGTC_2593 nobiletin 86.24 µM -0.866915230053435 0.180473754267637 no 2760 0.192994229046415 3947 72344 An anti-infammatory. SGTC_621 3584-0052 32.1 µM -0.867736181366827 0.180238300156575 no 2761 0.192769386958111 3907 2273927 SGTC_1402 3909-7673 35.9 µM -0.869255586090486 0.17980303398887 no 2762 0.192353674921411 3924 5328014 SGTC_3227 9130768 49.47 µM -0.871037531961147 0.179293399338714 no 2763 0.191866830236759 3955 17720899 SGTC_1610 st001799 48.1 µM -0.87138619731812 0.179193787772432 no 2764 0.191771659832989 3835 621897 SGTC_2832 7992762 51.95 µM -0.871565363586028 0.179142614604189 no 2765 0.191722766517273 3894 2985177 SGTC_2486 5283202 22.39 µM -0.871776148197048 0.179082422428503 no 2766 0.191665254534378 3992 1377751 SGTC_1668 st014914 51.6 µM -0.872709980445649 0.178815908056301 no 2767 0.191410588175164 3939 2839556 SGTC_2269 7935389 174.42 µM -0.873466092347636 0.178600297831359 no 2768 0.191204540106374 3881 97605 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.873654319382415 0.178546649130647 no 2769 0.191153267500252 4012 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2656 pseudo-anisatin 100 µM -0.873912388152093 0.178473110552448 no 2770 0.191082983871833 3967 6708809 A neurotoxin. SGTC_3196 9111891 49.47 µM -0.873928830347452 0.178468425875572 no 2771 0.191078506466242 3927 18891510 SGTC_1963 st076565 50.3 µM -0.874985648120971 0.178167482009023 no 2772 0.190790857377453 3950 4914280 SGTC_1352 1496-0991 99 µM -0.876121046753812 0.177844517783612 no 2773 0.19048211607765 3927 3000039 SGTC_2142 5622915 118.518 µM -0.877880125232242 0.177344877529165 no 2774 0.190004387958528 3951 5322196 SGTC_3015 9080845 49.47 µM -0.878012682107864 0.177307262651527 no 2775 0.189968418207858 4006 5296973 SGTC_2067 5224629 34.075 µM -0.878019329177243 0.177305376584766 no 2776 0.189966614613614 3947 2835000 SGTC_2529 gangaleoidin 93.61 µM -0.879108433523337 0.176996520746079 no 2777 0.189671242741672 3967 4565183 SGTC_971 1315-0384 26.7 µM -0.879847717263096 0.176787063303206 no 2778 0.189470905447422 3974 6769120 SGTC_1153 4055-0057 267 µM -0.879857417777058 0.176784315948598 no 2779 0.189468277586792 3984 882706 SGTC_3046 9092212 49.47 µM -0.883744674066357 0.175685550106157 no 2780 0.188417029230066 3991 25236637 SGTC_2243 6634756 200 µM -0.885669128691637 0.175143191510223 no 2781 0.187897924228619 4029 885676 SGTC_1224 0823-0416 294 µM -0.885916324563532 0.175073602689036 no 2782 0.187831309339363 4034 3598164 SGTC_1638 st008370 60.6 µM -0.886106446864527 0.175020092747882 no 2783 0.187780084685691 3924 24207134 SGTC_1762 st045503 25.4615 µM -0.886184467981515 0.174998136699638 no 2784 0.1877590659524 4046 4645554 SGTC_1381 2324-0066 62.1 µM -0.886376885566964 0.174943995626895 no 2785 0.18770723525011 4013 10885928 SGTC_482 fipronil 114 µM -0.887523782895773 0.174621510444908 no 2786 0.187398483792875 4016 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2236 dapsone 200 µM -0.8898006633176 0.173982415367485 no 2787 0.186786465178923 3953 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3022 9087993 49.47 µM -0.889915834249347 0.173950127728469 no 2788 0.18675554048555 4007 17173644 SGTC_1328 1441-0025 69.2 µM -0.889995144847369 0.173927895583827 no 2789 0.186734246538753 3907 4562601 SGTC_2895 9054447 58.44 µM -0.891239235248901 0.17357939182179 no 2790 0.186400419869295 3993 2697450 SGTC_3268 9137683 49.47 µM -0.892801088715059 0.173142503496208 no 2791 0.185981851612351 3979 1953228 SGTC_1863 st057641 20.1 µM -0.894267087811191 0.172733065746456 no 2792 0.185589502462723 3970 3921635 SGTC_2467 5474540 200 µM -0.894891648068505 0.172558820429899 no 2793 0.185422505912545 3918 5413519 SGTC_2313 7726885 200 µM -0.895065469777325 0.172510346064742 no 2794 0.185376045608665 4016 726423 SGTC_423 5-fluorouracil 457 µM -0.896520576631368 0.172104895196754 no 2795 0.184987397824121 3927 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3097 9117246 49.47 µM -0.898245874286237 0.171624947172213 no 2796 0.184527240709769 3975 16423892 SGTC_412 gemfibrozil 100 µM -0.898398820228764 0.171582441552382 no 2797 0.184486482614007 3899 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_748 act1.228 77.9 µM -0.899156192703785 0.171372057256381 no 2798 0.184284735271967 3913 4421505 YNR035C ARC35 SGTC_1864 st057645 30.4 µM -0.901371327335578 0.170757680025186 no 2799 0.183695460564251 4012 688666 SGTC_2118 5526350 200 µM -0.901721107938572 0.170660795882867 no 2800 0.183602518644067 4017 743594 SGTC_395 anisomycin 6.25 µM -0.90173235576321 0.170657680983033 no 2801 0.183599530415791 3989 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2189 6047310 154.431 µM -0.902897937117746 0.170335089726225 no 2802 0.183290032795619 3934 711535 SGTC_707 0865-0008 204 µM -0.903009084653532 0.170304348474117 no 2803 0.183260536714376 3976 723043 SGTC_3112 9123419 49.47 µM -0.903152467356086 0.170264696850329 no 2804 0.183222490510227 4010 17015854 SGTC_594 1487-1584 10.8 µM -0.904637648173842 0.16985432699866 no 2805 0.182828691710264 3938 5013332 SGTC_274 sirtinol 40.1 µM -0.90483353471113 0.169800249027796 no 2806 0.182776791449136 4038 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1446 4239-0190 62 µM -0.905476048070744 0.169622949268935 no 2807 0.182606621697952 3993 1340085 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.906006707313481 0.169476604920525 no 2808 0.182466151151798 4068 688801 SGTC_2957 9076800 11.52 µM -0.90660597507129 0.169311437265859 no 2809 0.182307600457766 3948 16459615 SGTC_2830 7992007 71.43 µM -0.907250042328345 0.169134037402813 no 2810 0.182137292993925 3870 1952075 SGTC_14 0354-0009 295 µM -0.907687005728288 0.169013749557827 no 2811 0.182021805604337 4045 1713507 SGTC_1318 1280-3875 124 µM -0.911184971261905 0.16805280630098 no 2812 0.18109896062033 4004 373245 SGTC_1165 k072-0275 30.3 µM -0.911939081883649 0.167846102478242 no 2813 0.180900393363302 3966 6153523 YGL055W OLE1 SGTC_1545 lovastatin 49.4 µM -0.914363985818334 0.167182539496053 no 2814 0.180262809542358 4071 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1770 st043884 66.3 µM -0.916396731091449 0.16662759364948 no 2815 0.179729424617874 3981 670149 SGTC_1520 flindersine 88 µM -0.916619428311722 0.166566868947437 no 2816 0.179671050008247 4124 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3017 9080681 49.47 µM -0.917022786079925 0.166456918403237 no 2817 0.17956535000487 4012 16451914 SGTC_1667 st014849 34.6 µM -0.91710259431752 0.166435169178092 no 2818 0.179544440868611 4031 5348460 SGTC_2683 piperine 63.03 µM -0.917329733458141 0.166373279591031 no 2819 0.179484940559673 3969 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3156 9099931 49.47 µM -0.917829536008576 0.166237148554529 no 2820 0.179354058266562 4008 18111053 SGTC_343 4130-2827 29.8 µM -0.918176595678323 0.166142662375505 no 2821 0.179263209758234 4026 1118244 SGTC_306 1672-3436 11.6 µM -0.918880044447978 0.165951256549045 no 2822 0.179079159405193 4036 6797378 SGTC_2513 baicalein 25.65 µM -0.919685757675143 0.165732200099606 no 2823 0.17886849869764 4000 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_125 0133-0007 11.75 µM -0.920418244063388 0.165533214797459 no 2824 0.178677119195423 4065 26541 SGTC_131 0141-0277 33.849 µM -0.920528038395406 0.165503401684227 no 2825 0.178648443928497 3980 1547771 SGTC_972 1319-0219 195 µM -0.92411577296094 0.164531113895069 no 2826 0.17771302097853 3974 23903702 SGTC_1696 st025591 34.7925 µM -0.92427642085744 0.164487664555349 no 2827 0.177671207980633 4007 2787147 SGTC_772 k072-0172 35.3 µM -0.926627314344766 0.16385268528264 no 2828 0.177060034042552 4042 5861980 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.927048471527014 0.163739098444824 no 2829 0.176950684086593 3987 16486 A toxic proline analog. SGTC_363 0455-0021 3.06 µM -0.927419138818294 0.163639171118936 no 2830 0.176854478726676 3999 4597466 SGTC_1062 mesoridazine 14.2 µM -0.930499190929344 0.162810358915176 no 2831 0.176056341422817 4010 4078 A neuroleptic. SGTC_3204 9114183 49.47 µM -0.931633177284914 0.162505902935354 no 2832 0.175763065526342 4011 17027248 SGTC_1436 4092-1007 8.32 µM -0.932522433760241 0.162267412091549 no 2833 0.175533299241993 3985 2881121 SGTC_3198 9112019 49.47 µM -0.932663470725186 0.162229608151531 no 2834 0.175496875577816 4059 45595555 SGTC_2600 tangeritin 87.95 µM -0.934015133154574 0.161867595640272 no 2835 0.175148043423358 3950 68077 A bioactive flavone. SGTC_1316 1272-0050 65.9 µM -0.938058198522967 0.160787895398698 no 2836 0.17410725115319 3976 7340392 SGTC_1237 0330-0133 46.1 µM -0.938843105729287 0.160578832317393 no 2837 0.173905651835285 3948 X1237 YHR072W ERG7 SGTC_403 arphamenine a 50 µM -0.941113762630997 0.159975034324281 no 2838 0.173323281729598 3984 5487158 An arginine aminopeptidase inhibitor. SGTC_1776 st049249 45.9 µM -0.941679486363822 0.15982483217297 no 2839 0.173178380328679 4056 1822314 SGTC_419 nsc-638432 893 µM -0.943738030231283 0.159279058549714 no 2840 0.172651767453162 3993 368090 SGTC_726 3448-4391 34.2 µM -0.944368653727116 0.159112108333297 no 2841 0.172490647020445 4135 1356692 SGTC_146 3448-8650 53.125 µM -0.946898836692282 0.158443424966524 no 2842 0.171845165393949 4006 2891488 YIL048W NEO1 SGTC_793 0488-0545 106 µM -0.948394836982742 0.158048926521047 no 2843 0.171464243425742 4050 292548 SGTC_3098 9119039 49.47 µM -0.948461607199028 0.158031334118219 no 2844 0.171447254519829 4025 17161528 SGTC_1515 3460-0031 42.1 µM -0.949545765321133 0.157745863511833 no 2845 0.171171553641422 3963 2876596 SGTC_966 1300-0360 30.2 µM -0.950849414711998 0.157403047277523 no 2846 0.17084041188058 4016 70588 SGTC_1887 st057648 70.8 µM -0.950949423381647 0.157376768578005 no 2847 0.170815025483237 4045 688672 SGTC_1391 3442-0225 151 µM -0.951168890205076 0.157319110659352 no 2848 0.170759324055361 4002 5227075 SGTC_582 0987-0078 156 µM -0.951756071308219 0.157164915812568 no 2849 0.170610352656319 4068 1625765 SGTC_2697 mebhydrolin 72.4 µM -0.952581759381017 0.156948256785642 no 2850 0.170401011403541 4123 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_719 2810-4230 27.3 µM -0.953714267430493 0.156651408490884 no 2851 0.170114148085313 4028 721079 SGTC_2580 diallyl disulphide 81.36 µM -0.954914190866265 0.156337293050444 no 2852 0.169810546378421 4029 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_313 3474-0040 5.03 µM -0.955391099057882 0.156212563519414 no 2853 0.169689976778326 4028 1043375 YIL048W NEO1 SGTC_1960 st011366 51.8 µM -0.955758239076219 0.156116587192219 no 2854 0.169597195647373 4053 3972846 SGTC_2452 5863136 48.41 µM -0.959092597995185 0.155246711196511 no 2855 0.168756049499267 4004 2184096 SGTC_1962 st076595 64.5 µM -0.959265753646599 0.155201625464208 no 2856 0.168712441524977 4039 279619 SGTC_1124 fisetin 1.16336 µM -0.959458801560554 0.155151370436882 no 2857 0.16866383236968 4070 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2416 tofa 880 nM -0.961413923609767 0.154643010427522 no 2858 0.168172043080423 4076 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2858 9025781 8.96 µM -0.962966434282077 0.154240120137175 no 2859 0.167782184064095 3977 4894980 YPL153C RAD53 SGTC_1159 4092-0538 61.2 µM -0.964842803032797 0.153754113118335 no 2860 0.167311776690355 4078 717301 SGTC_1565 sinapyl alcohol 95.1 µM -0.964986793139183 0.153716859496822 no 2861 0.167275713388668 4097 5280507 A phenol propionate derived from cinnamic acid. SGTC_3141 9094609 49.47 µM -0.965655636343825 0.153543892405871 no 2862 0.167108262751956 4003 25236309 YDL196W YDL196W SGTC_165 k038-0023 64.381 µM -0.966154605961523 0.153414939677377 no 2863 0.166983411839878 4057 46368543 SGTC_3229 9132204 49.47 µM -0.966256960731067 0.15338849618156 no 2864 0.166957808326837 4101 17682924 SGTC_1092 toremifene 6.32 µM -0.967352595194759 0.153105626658356 no 2865 0.166683899687549 4031 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1893 st059353 36.1 µM -0.970212431954117 0.152368907658297 no 2866 0.165970307601101 4057 3112488 SGTC_1493 4348-0038 111 µM -0.973059705398643 0.151637766351351 no 2867 0.165261814549318 4034 800424 SGTC_271 rotenone 740 µM -0.973123645178132 0.151621374297414 no 2868 0.165245926782073 4108 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_253 dyclonine 31.25 µM -0.974218582728636 0.15134085115387 no 2869 0.164974009923041 4153 3180 An oral anasthetic. SGTC_2170 morpholine 200 µM -0.974751025472652 0.151204564068526 no 2870 0.164841887819965 4090 121171 Reacts with secondary amines. SGTC_1006 4099-6547 255 µM -0.975619542160233 0.150982428838447 no 2871 0.164626518333221 4104 3146833 SGTC_1613 st002381 52.1 µM -0.975847852370943 0.150924071393224 no 2872 0.164569933633812 4047 551167 SGTC_1210 3013-0140 750 nM -0.97598238628471 0.150889690757011 no 2873 0.164536596476139 4094 905973 SGTC_3115 9123671 49.47 µM -0.97817792563956 0.150329349383958 no 2874 0.163993166066521 4161 3286988 SGTC_2655 perillic acid 100 µM -0.979218135512736 0.150064353716796 no 2875 0.163736104832735 4090 5702197 An apoptosis inducer. SGTC_2991 9074669 71.4286 µM -0.97957273532379 0.149974089884891 no 2876 0.16364853438224 4083 17333109 SGTC_2560 caryophyllene 100 µM -0.979947485365515 0.149878736142098 no 2877 0.163556020771394 4098 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_124 0136-0217 7.121 µM -0.979978041095807 0.149870963134306 no 2878 0.163548479051964 4105 3976905 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.981928305523868 0.149375395684171 no 2879 0.163067584921353 4046 641818 YHR062C RPP1 SGTC_1024 4507-0395 26 µM -0.986940226316126 0.148106876066259 no 2880 0.161835971227452 4156 4201836 SGTC_1632 st005650 90 µM -0.986952282473361 0.148103833364155 no 2881 0.16183301591165 4111 2759605 SGTC_2366 9070441 60.58 µM -0.987274366314133 0.14802256215509 no 2882 0.161754076785861 4073 6837235 SGTC_2558 carylophyllene oxide 100 µM -0.987472865829097 0.147972489769088 no 2883 0.161705439287991 4189 6708694 An oxygenated terpenoid and antifungal agent. SGTC_371 0195-0006 7.36 µM -0.991349026855905 0.146996983239927 no 2884 0.160757590522015 3918 3928593 SGTC_914 3820-6779 408 µM -0.992151454639318 0.146795577715675 no 2885 0.160561824719867 4030 2893481 SGTC_2181 6316240 54.2555 µM -0.992481257983019 0.146712852364558 no 2886 0.160481408802012 4101 12779990 SGTC_3070 9117005 49.47 µM -0.993737501146441 0.146398032466841 no 2887 0.160175340197142 4164 8779016 SGTC_3256 9138902 49.47 µM -0.995249917965074 0.14601961648397 no 2888 0.159807364539223 4152 17228773 SGTC_1526 st051518 75 µM -0.9956561323407 0.145918091208399 no 2889 0.15970862562434 4085 673993 SGTC_921 1561-0023 372 µM -0.995687609302767 0.14591022614295 no 2890 0.159700976156019 4048 24050882 SGTC_2178 5812956 200 µM -0.998089425830276 0.145310930720603 no 2891 0.159117998579385 4044 5403383 SGTC_2853 9015042 58.44 µM -0.999857278838297 0.144870879809084 no 2892 0.158689790738749 4004 6457456 SGTC_2784 7567673 72.73 µM -1.00024919655359 0.144773445966396 no 2893 0.158594963173899 4063 3471247 SGTC_1458 k015-0034 6.33 µM -1.00097214432479 0.144593831242901 no 2894 0.158420137803814 4119 3598957 SGTC_1873 rapamycin 2 nM -1.00115935988895 0.144547342445402 no 2895 0.158374885397396 4049 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_703 3875-0075 71.8 µM -1.00163354746211 0.144429638693079 no 2896 0.158260306115064 4125 2850814 SGTC_77 0828-0286 12.516 µM -1.00188122053085 0.144368186491954 no 2897 0.158200481802445 4007 745345 SGTC_2251 lansoprazole 556 µM -1.00195340655342 0.144350279141443 no 2898 0.158183048387753 4019 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_523 1934-0222 13.7 µM -1.0020458778761 0.14432734175779 no 2899 0.158160717777449 4055 1361595 SGTC_2904 7225135 42.03 µM -1.00223906404465 0.144279430123469 no 2900 0.15811407253078 4197 4446116 SGTC_1374 2889-5571 141 µM -1.00227200018042 0.144271262781968 no 2901 0.158106120925759 4148 2853281 SGTC_1931 st074438 57.1 µM -1.00264854336153 0.144177911598192 no 2902 0.158015232660289 4050 2787313 SGTC_2000 st075254 36.4 µM -1.00355056541789 0.143954451306 no 2903 0.157797646245393 3997 17234175 SGTC_1743 st037606 46.3785 µM -1.00452376081076 0.143713621165073 no 2904 0.157563112136372 4067 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1934 st074720 32.6 µM -1.00601983992496 0.143343926997822 no 2905 0.157203013201628 4049 17250992 SGTC_463 ikarugamyin 104 µM -1.01312874653259 0.141596034891005 no 2906 0.155499334542685 4191 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3243 9134147 49.47 µM -1.01313888017868 0.141593553646302 no 2907 0.155496914699863 4167 24282180 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.01320161617352 0.141578193260812 no 2908 0.155481934342194 4141 279621 SGTC_174 3553-0389 74.3 µM -1.01432935663847 0.14130226795289 no 2909 0.15521281025636 4183 738071 SGTC_2698 st077697 67.5 µM -1.01756620331848 0.140512331340133 no 2910 0.154442077708867 4074 3154499 SGTC_655 k060-0012 42 µM -1.0186664776376 0.140244498806989 no 2911 0.154180666197918 4093 5994525 SGTC_2875 9039966 71.43 µM -1.01904870669015 0.140151536510711 no 2912 0.154089921856889 4118 6463691 SGTC_1072 oxiconazole 14.9 nM -1.01923935137533 0.140105185282869 no 2913 0.154044674439267 4111 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.02197126370178 0.139442122374503 no 2914 0.153397250698546 4074 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1786 berberine 21.6 µM -1.0269330722774 0.138243307629823 no 2915 0.152225989984826 4027 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_72 0744-0168 198.391 µM -1.02730176265269 0.138154510228424 no 2916 0.152139196325226 4013 677577 SGTC_99 0109-0120 622.8 µM -1.0285580017502 0.137852242809406 no 2917 0.151843710980043 4098 759414 SGTC_1485 3909-9022 254 µM -1.03197764505665 0.137031719300414 no 2918 0.151041295016633 4157 714516 SGTC_1163 k060-0048 49.9 µM -1.03296981754637 0.136794279139253 no 2919 0.150809011788147 4112 6809982 SGTC_355 1311-2252 105 µM -1.03380496340038 0.136594635674709 no 2920 0.150613675406901 4111 5338538 SGTC_1957 st077035 62.4 µM -1.03523759583201 0.136252625981028 no 2921 0.150278982563442 4128 705593 SGTC_2233 sulbentine 40.3845 µM -1.03773678499489 0.135657402883389 no 2922 0.149696307160181 4116 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1469 k284-2957 126 µM -1.03871765923152 0.135424278975666 no 2923 0.14946803289129 4110 23884841 SGTC_70 0141-0289 43.283 µM -1.03879901842773 0.135404954713062 no 2924 0.149449108987083 4112 352408 SGTC_2661 dactinomycin 12.96 µM -1.03970626612867 0.13518959520876 no 2925 0.149238194251659 4090 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2365 9042475 200 µM -1.04496350489955 0.133946273151053 no 2926 0.148019918549654 4219 6464479 SGTC_1076 itraconazole 331 nM -1.05563622540745 0.131446433306614 no 2927 0.145567221995556 4147 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1214 0358-0031 63.7 µM -1.05658089302038 0.1312267284875 no 2928 0.145351452225483 4265 4301366 SGTC_361 000s-0510 1.45 µM -1.0570835887754 0.131109918135386 no 2929 0.14523672017641 4102 660 SGTC_1063 disulfiram 1.84 µM -1.05753894968007 0.131004168900209 no 2930 0.1451328441422 4155 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2817 7995342 71.43 µM -1.05753974314139 0.131003984684789 no 2931 0.145132663183012 4150 18879975 SGTC_2658 polymyxin b sulfate 77.05 µM -1.05865911058663 0.130744282873493 no 2932 0.144877528060204 4177 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3120 9124077 49.47 µM -1.05932846502301 0.130589157664394 no 2933 0.144725107846873 4268 18774327 YGL155W CDC43 SGTC_3288 9119690 36.221 µM -1.05949508672497 0.130550562298668 no 2934 0.144687182836581 4152 17595618 YKL019W RAM2 SGTC_3192 9110362 49.47 µM -1.06083442461912 0.130240611709657 no 2935 0.144382577340634 4172 16649480 SGTC_2135 5326629 150.42 µM -1.06247790974027 0.129860971339221 no 2936 0.144009390610125 4113 5020077 SGTC_1965 Pectolinarigenin 58.4 µM -1.06553499219414 0.129156833738917 no 2937 0.143316949670926 4121 5320438 An anti-inflammatory. SGTC_3092 9117248 49.47 µM -1.06661859395826 0.128907884366342 no 2938 0.143072050311735 4270 17141857 SGTC_2044 5102272 200 µM -1.0670835263211 0.128801171744743 no 2939 0.142967060027528 4164 592666 SGTC_595 3909-8003 73.7 µM -1.07006954514846 0.128117272774384 no 2940 0.142294003111677 4232 699517 SGTC_2802 7925815 54.55 µM -1.07101710678182 0.127900777364125 no 2941 0.142080868925562 4132 1262923 SGTC_2715 st079500 56.4 µM -1.07309496697536 0.127426925743635 no 2942 0.141614254483591 4131 28246688 SGTC_1789 tunicamycin 25 nM -1.07509564222726 0.126971831011182 no 2943 0.141165955152413 4072 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2203 7227154 166.4 µM -1.07846722705162 0.12620745677933 no 2944 0.140412649844951 4177 896304 SGTC_1102 cgs 12066b 26.1 µM -1.07936902960243 0.126003553303577 no 2945 0.140211625724501 4168 6438352 A 5-HT1B full agonist. SGTC_782 0083-0095 30.5 µM -1.08200578388312 0.125408683916699 no 2946 0.139624978956557 4157 3591729 An indicator and reagent. SGTC_1258 0671-0043 57.1 µM -1.08215888200798 0.125374204272379 no 2947 0.139590967771796 4199 4298767 SGTC_1504 k297-0033 30 µM -1.08591955329063 0.12452933035997 no 2948 0.13875729262823 4055 4388117 SGTC_900 1112-0045 141 µM -1.08665837881726 0.1243638144332 no 2949 0.138593907296188 4056 56211 YIL048W NEO1 SGTC_2993 9054257 71.4286 µM -1.08669845883457 0.124354839879555 no 2950 0.138585047671862 4109 6470217 YGL055W OLE1 SGTC_486 niguldipine 82 µM -1.08767619398304 0.124136049700357 no 2951 0.13836904038195 4238 1236 A calcium channel blocker. SGTC_3053 9095903 49.47 µM -1.08768706959702 0.124133617553109 no 2952 0.138366638965299 4278 17174018 SGTC_3184 9108758 49.47 µM -1.08796982193924 0.124070396471243 no 2953 0.138304215109776 4203 902885 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.09049733832694 0.123506265453283 no 2954 0.137747062573896 4155 688803 SGTC_2364 9055074 200 µM -1.09136153735301 0.123313792660622 no 2955 0.137556914890726 4206 6470630 SGTC_2276 7947513 42.08 µM -1.0916000619417 0.123260705937765 no 2956 0.137504464451895 4135 2105100 SGTC_60 0986-0278 202 µM -1.09410750720673 0.12270361058166 no 2957 0.136953915149436 4139 3110598 SGTC_2617 dihydrotanshinone i 20.83 µM -1.09805230469434 0.121830748512771 no 2958 0.136090825199262 4165 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2071 5230951 39.92 µM -1.10046496207561 0.121299056559699 no 2959 0.135564793848778 4228 1799272 SGTC_2762 leflunomide 42.06 µM -1.10134366614608 0.121105817168171 no 2960 0.135373556658013 4166 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2903 5923464 63.88 µM -1.10308935851965 0.120722557551767 no 2961 0.134994180806747 4196 2876576 SGTC_1615 st002656 86.5 µM -1.10453478037563 0.120405867865468 no 2962 0.134680612430209 4194 1584458 SGTC_765 1319-0117 244 µM -1.10805984955957 0.119635985600677 no 2963 0.133917984669199 4165 3487746 YGL099W LSG1 SGTC_1848 st056003 16.4 µM -1.11063725536666 0.119075276717689 no 2964 0.133362259931185 4214 146492 SGTC_1731 st035964 63 µM -1.11090574967243 0.119016973263583 no 2965 0.133304460177842 4130 6739575 SGTC_2339 9000433 200 µM -1.11471530169351 0.118191901592385 no 2966 0.132486220859252 4233 2988954 SGTC_2806 7952793 58.44 µM -1.11661408244097 0.1177821780157 no 2967 0.132079683878544 4269 2972490 SGTC_347 4534-1311 26.2 µM -1.11914405071232 0.11723781853115 no 2968 0.131539344851561 4223 2862016 SGTC_978 1416-0512 87.4 µM -1.12197734115837 0.116630313060756 no 2969 0.130936037100777 4297 6814003 SGTC_952 1185-0122 232 µM -1.12547385939886 0.115883681948129 no 2970 0.13019414415695 4173 678600 SGTC_905 2-aminofluorene 215 µM -1.12558928988587 0.115859091433677 no 2971 0.130169701757445 4234 1539 An established DNA mutagen. YPR165W RHO1 SGTC_197 4544-0043 41.561 µM -1.12574881654284 0.115825113074719 no 2972 0.130135927223161 4216 896523 SGTC_385 1494-0393 12.4 µM -1.1290662395266 0.115120122157362 no 2973 0.12943494587813 4193 3090647 SGTC_2710 st078562 53.7235 µM -1.12931098184338 0.115068232683284 no 2974 0.129383334926181 4164 17250908 SGTC_214 4373-3496 70 µM -1.13128414811656 0.114650495856905 no 2975 0.128967757061832 4305 3779166 SGTC_144 4161-2749 112.381 µM -1.13349461140745 0.114183804120145 no 2976 0.128503301410759 4179 797501 YMR168C CEP3 SGTC_2824 7998404 51.95 µM -1.1351116071864 0.113843268218877 no 2977 0.128164279419821 4190 837851 SGTC_96 0929-0093 37.281 µM -1.13651517861973 0.113548266325807 no 2978 0.127870508361754 4235 6991579 SGTC_1925 st057770 10.1 µM -1.13768158424103 0.113303526826456 no 2979 0.127626732964215 4221 5989122 SGTC_1417 3966-0327 90.4 µM -1.14061465609044 0.11268976235827 no 2980 0.127015157767041 4328 651118 SGTC_2534 helenine 20.12 µM -1.1432097761587 0.112148699319007 no 2981 0.126475752130107 4242 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.1435495066333 0.112078005756463 no 2982 0.126405256159929 4280 91467 include heat shock SGTC_1226 3909-7979 35.4 µM -1.14585849970049 0.111598377803061 no 2983 0.125926852565936 4232 6615510 SGTC_157 1348-1695 65.819 µM -1.14712963938316 0.111334962141207 no 2984 0.125664022857193 4177 5380510 SGTC_1594 piperine 70.1 µM -1.1522631709348 0.11027567964555 no 2985 0.124606473037032 4221 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1281 0884-0031 11.8 µM -1.15345762213451 0.110030249637809 no 2986 0.12436130102572 4264 1548255 SGTC_980 1473-0395 201 µM -1.15357725686876 0.110005689285275 no 2987 0.124336763503998 4124 768876 SGTC_560 2332-1943 155 µM -1.15491309952074 0.109731715285782 no 2988 0.124063007257944 4212 21177716 SGTC_136 0097-0015 404.482 µM -1.15536576238256 0.109638987821904 no 2989 0.123970338116473 4245 4861337 SGTC_2855 9016525 58.44 µM -1.15824364949913 0.109050771640823 no 2990 0.123382310047289 4200 43811474 SGTC_1307 1187-1599 12.2 µM -1.15875681232619 0.108946124150751 no 2991 0.123277662995696 4235 1538471 SGTC_1441 4106-0040 13 µM -1.15944456071203 0.108805987274938 no 2992 0.123137511026854 4249 2904180 SGTC_680 0417-1641 114 µM -1.16086466202069 0.108517035041209 no 2993 0.122848470870753 4245 2835990 SGTC_2775 cyproheptadine 69.59 µM -1.16119611751325 0.108449672339578 no 2994 0.122781076652931 4250 2913 A selective serotonin reuptake inhibitor. SGTC_3172 9105863 49.47 µM -1.1615139837448 0.108385099690308 no 2995 0.12271646987478 4313 2348785 SGTC_2304 7443016 91.4 µM -1.16185894822794 0.108315053499945 no 2996 0.122646382322299 4184 939854 SGTC_3113 9123498 49.47 µM -1.16212548555112 0.108260954520615 no 2997 0.122592248303853 4363 8897275 SGTC_1372 2752-0194 270 µM -1.16227839969857 0.108229926374351 no 2998 0.122561198843584 4181 823334 SGTC_1819 st053448 58.6 µM -1.16400239709502 0.107880549071375 no 2999 0.12221152016964 4145 2857616 SGTC_2387 9077560 195.08 µM -1.16559022462723 0.107559486548449 no 3000 0.121890081002396 4261 5303272 SGTC_2867 9039098 71.43 µM -1.16563227228678 0.107550993779531 no 3001 0.121881576970415 4218 6463460 SGTC_1857 st056007 79.3 µM -1.16564270320507 0.107548887021772 no 3002 0.121879467408298 4228 619834 SGTC_678 1218-2179 85.9 µM -1.16596240071171 0.107484331367101 no 3003 0.121814823819643 4272 6820081 YOR116C RPO31 SGTC_2822 7994718 71.43 µM -1.16661200696115 0.107353244164976 no 3004 0.121683546115097 4232 1018011 SGTC_641 4092-0595 30 µM -1.1678062808256 0.107112546619141 no 3005 0.121442457025779 4299 786260 SGTC_901 1112-0062 60.1 µM -1.16849639259298 0.10697363697178 no 3006 0.121303296758981 4263 1908457 SGTC_3135 9127742 49.47 µM -1.17016930207054 0.106637443603274 no 3007 0.120966421925494 4357 3643468 SGTC_2280 7785178 200 µM -1.17025472063483 0.106620298095675 no 3008 0.120949238816798 4247 2954328 SGTC_1697 st025554 27.742 µM -1.17131464129176 0.106407712695078 no 3009 0.120736164197028 4251 1269519 SGTC_3193 9111931 49.47 µM -1.17143424460396 0.106383743414787 no 3010 0.120712137082628 4267 17087244 SGTC_3138 9097216 49.47 µM -1.17166773973568 0.10633696071047 no 3011 0.120665239936111 4203 25237486 SGTC_2961 9083290 32.55 µM -1.17480257346786 0.105710308744105 no 3012 0.120036855165892 4204 17741490 SGTC_903 1134-0042 114 µM -1.17542210710608 0.105586780828938 no 3013 0.119912941638163 4266 701009 SGTC_999 SEC7.066 22.7 µM -1.17701679264798 0.105269298995052 no 3014 0.119594401893683 4217 740511 YDR170C SEC7 SGTC_924 2046-0044 21.3 µM -1.17931998353468 0.104811982681675 no 3015 0.119135391910484 4245 3623589 SGTC_1752 st044819 83.042 µM -1.1796424583783 0.10474806779967 no 3016 0.1190712242969 4237 441209 YML126C ERG13 SGTC_2665 lovastatin 100 µM -1.17995109538797 0.104686922031394 no 3017 0.119009833059515 4293 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_497 capsazepine 133 µM -1.18067933831259 0.104542748308296 no 3018 0.118865066262668 4231 2733484 A calcium channel blocker. SGTC_3206 9114350 49.47 µM -1.18152043392031 0.104376411671205 no 3019 0.118698020409459 4134 17087243 SGTC_126 0417-1624 672.48 µM -1.18748766975398 0.103201824533838 no 3020 0.117517658669104 4322 41912 YDL195W SEC31 SGTC_471 1-acyl-paf 4 µM -1.18845982753433 0.103011378413105 no 3021 0.117326148906687 4216 16759367 SGTC_184 1494-0393 24.714 µM -1.18918807784403 0.102868881208441 no 3022 0.117182832459637 4240 3090647 SGTC_2451 5856223 45.7 µM -1.19085807137371 0.102542653407598 no 3023 0.116854653493824 4249 2179896 SGTC_2404 5161160 200 µM -1.19184691189765 0.102349841503069 no 3024 0.116660638746554 4221 2831543 SGTC_1109 tnp00067 928.257 nM -1.19228890355194 0.102263743808 no 3025 0.116573991995353 4285 676295 SGTC_3267 9137951 49.47 µM -1.19296306453959 0.102132522196696 no 3026 0.116441919359566 4306 16643986 SGTC_1847 st056231 15 µM -1.19642782168603 0.101460059166126 no 3027 0.115764824824625 4279 5393180 SGTC_1052 3253-3998 198 µM -1.19899633580727 0.100963630530324 no 3028 0.115264685193244 4221 5450317 SGTC_1003 4049-0218 100 µM -1.19934957230361 0.100895497618224 no 3029 0.115196023505005 4302 295161 SGTC_1633 st005664 67.9 µM -1.20008728542635 0.100753314261206 no 3030 0.115052721496771 4266 2063822 SGTC_300 r073-0011 5.04 µM -1.20174855533345 0.100433664060236 no 3031 0.114730481311311 4287 2735780 SGTC_399 oxolinic acid 75 µM -1.20400291692737 0.100001079520525 no 3032 0.114294225563866 4260 4628 A DNA gyrase inhibitor. SGTC_2581 avocatin a 64 µM -1.20442245596208 0.0999207254772201 no 3033 0.114213168455716 4242 6710728 A skin care supplement. SGTC_1898 st060199 18.6 µM -1.20481863531504 0.0998448887987884 no 3034 0.114136662150353 4267 688866 SGTC_1497 4476-2978 41.3 µM -1.20516656984956 0.0997783218284112 no 3035 0.114069502526876 4326 1528379 SGTC_1091 telmisartan 47.6 µM -1.21268833977988 0.0983471712440024 no 3036 0.112624499765468 4326 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2072 5231554 129 µM -1.21270901804135 0.0983432576669435 no 3037 0.112620545379235 4335 789545 SGTC_3072 9116419 49.47 µM -1.21326142496232 0.0982387511018251 no 3038 0.112514943111124 4333 17170162 SGTC_2726 cimetidine 79.27 µM -1.21467207446377 0.0979722478970998 no 3039 0.112245593720156 4291 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_787 4152-0075 138 µM -1.21482405055445 0.0979435678633505 no 3040 0.112216602928517 4306 9566539 SGTC_2714 st079313 56.9 µM -1.21572477999549 0.0977737137933771 no 3041 0.112044890619262 4275 2939799 SGTC_2785 7756463 72.73 µM -1.21575859760665 0.0977673408827992 no 3042 0.112038447393903 4273 2201551 SGTC_59 0330-0160 1.33 µM -1.21950336026499 0.097063524937839 no 3043 0.111326600631651 4261 4293482 SGTC_868 0527-0199 213 µM -1.21960436848233 0.0970445924156158 no 3044 0.111307444793636 4253 2849450 SGTC_473 2-arachidonoylglycerol 10 µM -1.2254050008775 0.095961890889709 no 3045 0.110211331828801 4133 5282280 An endocannabinoid. SGTC_1425 4048-4433 7.33 µM -1.22649976009132 0.0957585518906834 no 3046 0.110005332771141 4361 23734946 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.22804817172432 0.0954714936097641 no 3047 0.109714442606373 4294 16623 A steroid. SGTC_1484 3473-2379 286 µM -1.22833828985058 0.0954177794651726 no 3048 0.10966000145459 4431 671917 SGTC_1082 camptothecin 424.86 nM -1.22956684174168 0.0951905648241123 no 3049 0.109429676599725 4198 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2673 kobusone 100 µM -1.23009899680626 0.0950922691209757 no 3050 0.109330017845768 4406 6710676 An epoxy ketone and protein crosslinker. SGTC_2446 5162541 200 µM -1.23172429012207 0.0947925199541551 no 3051 0.109026046522077 4268 1549321 SGTC_589 1227-0070 34.1 µM -1.23218215841354 0.0947082021798474 no 3052 0.108940523237981 4366 2841384 SGTC_2016 5121758 140 µM -1.23291292838032 0.0945737433043476 no 3053 0.108804125729048 4250 2795203 SGTC_3028 9087778 49.47 µM -1.23654763694626 0.0939070610328731 no 3054 0.108127535014604 4289 17217395 SGTC_1443 4112-3303 14 µM -1.23739223840869 0.0937526411369257 no 3055 0.107970749449687 4354 704433 SGTC_2865 9030313 51.95 µM -1.23751751861667 0.0937297519215973 no 3056 0.107947507308272 4290 42562754 SGTC_3051 9093778 49.47 µM -1.23866348648644 0.0935205702649451 no 3057 0.107735073104792 4394 17217378 SGTC_504 lovastatin 124 µM -1.24044629299297 0.0931958276582149 no 3058 0.107405183698387 4338 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_860 0443-0016 25.1 µM -1.24076873638964 0.0931371828879474 no 3059 0.107345596809008 4338 5337942 SGTC_2323 6148992 148.28 µM -1.24250019473656 0.0928227382364899 no 3060 0.107026034342222 4292 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1705 st027868 56.3335 µM -1.24381635889688 0.0925842394987854 no 3061 0.106783579105733 4261 292948 SGTC_392 N-ethylmaleimide 8.33 µM -1.24440012238539 0.0924786024487447 no 3062 0.106676168950512 4274 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1669 st015249 58.4 µM -1.24743703461962 0.0919304853247128 no 3063 0.10611864710201 4418 722793 SGTC_2449 5812982 45.77 µM -1.25206424926201 0.091099973621672 no 3064 0.105273226707885 4257 776185 SGTC_709 3807-1509 243 µM -1.25262082675382 0.091000452903065 no 3065 0.105171865853273 4390 1886677 YPL242C IQG1 SGTC_1234 0326-0494 15.5 µM -1.25277523947377 0.090972856910885 no 3066 0.105143757570217 4401 1547813 SGTC_837 0091-0265 12.5 µM -1.25610503512775 0.0903792792492513 no 3067 0.104538945417356 4314 759367 SGTC_2417 cerulenin 830 nM -1.25640510994165 0.0903259287639602 no 3068 0.104484564957876 4335 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2774 tamoxifen 10.92 µM -1.26043892771242 0.089611022720327 no 3069 0.10375553311016 4319 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_263 alizarin 107.927 µM -1.26503732889826 0.0888011983000707 no 3070 0.102928973404326 4375 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_484 loperamide 105 µM -1.2697815643257 0.0879714155231563 no 3071 0.102081224703468 4410 3955 An opioid-receptor agonist. SGTC_3191 9110352 49.47 µM -1.27275135720976 0.087454939421567 no 3072 0.101553143545888 4301 17122424 SGTC_3326 9140064 16.379 µM -1.27567640142012 0.0869484611171609 no 3073 0.101034966973144 4299 1868434 SGTC_1820 st053765 18.6 µM -1.27807369710713 0.0865350001148287 no 3074 0.100611721106174 4394 3690829 SGTC_2984 9022109 38.96 µM -1.27830990277754 0.0864943414587454 no 3075 0.100570088767391 4376 6459207 SGTC_2401 5128683 200 µM -1.27921674113359 0.0863383778340356 no 3076 0.100410371066455 4362 708373 SGTC_139 0099-0334 718.624 µM -1.27944721597731 0.0862987728938215 no 3077 0.100369807997088 4371 97690 SGTC_826 1683-5028 118 µM -1.2814330988633 0.0859580802889197 no 3078 0.100020792283224 4383 722377 SGTC_3258 9138477 49.47 µM -1.28174834192758 0.0859040907495713 no 3079 0.0999654704272478 4376 4970355 SGTC_696 1560-0013 611 µM -1.28484248964269 0.0853755233723257 no 3080 0.0994236655480331 4400 1650269 SGTC_1339 1486-1321 22.7 µM -1.28819103358535 0.084806246902823 no 3081 0.0988397362150956 4382 3469382 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.28821473325394 0.0848022279575608 no 3082 0.0988356123568321 4472 16725076 SGTC_1126 isoteolin 1.0172 µM -1.28967339876633 0.0845551449930793 no 3083 0.0985820397024856 4297 133323 SGTC_3121 9125696 49.47 µM -1.29046177640493 0.0844218269263501 no 3084 0.0984451875032731 4472 1235365 SGTC_2320 7373003 200 µM -1.29082036160715 0.0843612408263887 no 3085 0.0983829877781334 4377 5415828 SGTC_20 0481-0013 4.944 µM -1.29123332518757 0.0842915074552701 no 3086 0.098311391311617 4407 182045 SGTC_880 0833-0487 87.2 µM -1.29206082690101 0.0841519050364394 no 3087 0.0981680402527038 4351 76075 SGTC_2727 riluzole 51.77 µM -1.29248731354748 0.0840800230654933 no 3088 0.0980942182820638 4394 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1609 st001574 46.4 µM -1.2996840890076 0.0828739885629915 no 3089 0.0968546329248644 4357 3960012 SGTC_1778 st046819 58.9 µM -1.30159066956309 0.0825566753231217 no 3090 0.0965281755440067 4409 671715 SGTC_330 1488-0319 80.1 µM -1.30192573466704 0.0825010048656282 no 3091 0.0964708870893068 4398 6846614 SGTC_745 0469-0705 296 µM -1.30195489678792 0.0824961609694865 no 3092 0.0964659022168843 4406 3486736 SGTC_2019 4016004 108 µM -1.30286105421113 0.0823457527801421 no 3093 0.0963111010853851 4386 45595336 SGTC_767 0929-0023 86 µM -1.30677043653872 0.0816992219742026 no 3094 0.0956453442329118 4391 1204563 SGTC_369 0957-0393 4.5 µM -1.30800788343074 0.0814953733312164 no 3095 0.0954353176974225 4376 6997992 SGTC_736 0958-0254 92.6 µM -1.31037695510922 0.081106178931655 no 3096 0.0950341728013101 4437 6812352 SGTC_3171 9103192 49.47 µM -1.31096233756724 0.0810102279429758 no 3097 0.0949352440977982 4452 13018434 SGTC_805 3852-0218 479 µM -1.31156994930625 0.0809107239603864 no 3098 0.094832638948535 4335 6615355 SGTC_679 0422-0091 41.4 µM -1.31200450547956 0.0808396165883086 no 3099 0.0947593071868062 4408 627384 YHR062C RPP1 SGTC_947 3447-0010 211 µM -1.3167035978419 0.0800737049078333 no 3100 0.0939689985850966 4337 748350 SGTC_3182 9108849 49.47 µM -1.31773498643243 0.0799063340036045 no 3101 0.0937961891446624 4385 17133045 SGTC_3241 9133421 49.47 µM -1.31992598151407 0.0795516634688653 no 3102 0.0934298660241942 4462 17018221 SGTC_55 0767-0285 6.563 µM -1.31995009607456 0.079547766527355 no 3103 0.0934258400815473 4287 3116166 SGTC_616 4092-0450 108 µM -1.32000276323138 0.0795392559547482 no 3104 0.0934170477086401 4382 787165 SGTC_74 000s-0487 160.283 µM -1.32157630444954 0.0792853025264467 no 3105 0.0931546390751326 4257 677548 SGTC_3221 9128209 49.47 µM -1.32212604987881 0.079196724083624 no 3106 0.0930630903336605 4404 16460723 SGTC_660 4031-1742 102 µM -1.3251000712415 0.0787188296996659 no 3107 0.0925689812613263 4272 6738706 SGTC_141 0443-0274 32.331 µM -1.32662907050052 0.0784739874783438 no 3108 0.092315707280288 4338 1627241 SGTC_3001 9076041 71.4286 µM -1.32794596169336 0.0782635737404785 no 3109 0.0920979797265839 4374 16004211 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.32815846578832 0.0782296598272647 no 3110 0.0920628811216019 4457 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2797 7859098 81.82 µM -1.32886964959168 0.0781162417830868 no 3111 0.091945489258896 4353 972681 SGTC_2098 5376439 882.5 nM -1.33038493154452 0.0778750039896469 no 3112 0.0916957383685529 4428 2844116 SGTC_2964 9083345 53.42 µM -1.33261216720687 0.0775214476624666 no 3113 0.0913295551097303 4364 17741579 SGTC_3007 9078383 71.4286 µM -1.33537583270085 0.0770844335002223 no 3114 0.0908766852159441 4388 6496995 SGTC_2987 9018338 71.43 µM -1.33557176884989 0.0770535216350154 no 3115 0.0908446413694541 4398 5055682 SGTC_1573 oleylamine 1.06 µM -1.33681173883751 0.0768581161954181 no 3116 0.0906420482215631 4389 5356789 An amine of the fatty acid oleic acid. SGTC_3167 9103034 49.47 µM -1.33980652631818 0.0763877250371394 no 3117 0.0901541266664381 4476 5127859 SGTC_1578 josamycin 24.2 µM -1.34135000111251 0.07614614847823 no 3118 0.0899034213982265 4394 5282165 A P450 substrate. SGTC_2971 9092186 9.93 µM -1.34233291786196 0.0759926108753268 no 3119 0.0897440373521328 4361 25236400 SGTC_689 0833-0039 98 µM -1.34349700200771 0.0758110788373092 no 3120 0.089555548072521 4349 5374726 SGTC_1029 k015-0030 64.7 µM -1.34430620082084 0.0756850837886288 no 3121 0.0894246956202061 4424 2208316 SGTC_673 1082-0474 110 µM -1.34711215015369 0.0752494232147913 no 3122 0.0889720577763249 4394 3098046 SGTC_1747 st037496 66.6 µM -1.34736386133296 0.0752104353779548 no 3123 0.0889315368450128 4359 723305 SGTC_3036 9090181 49.47 µM -1.34781072869562 0.0751412575170919 no 3124 0.0888596331584061 4454 25236586 SGTC_878 0828-0289 13.7 µM -1.34819303488282 0.075082112648912 no 3125 0.0887981521230026 4350 745350 YLR208W SEC13 SGTC_2234 tolnaftate 200 µM -1.35186320970724 0.0745161215218794 no 3126 0.0882095393483754 4498 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_9 0092-0002 10.449 µM -1.35280762186981 0.0743710084528444 no 3127 0.0880585485883665 4403 759368 SGTC_1447 4239-0816 81.9 µM -1.35529150174913 0.0739903794918119 no 3128 0.0876623507583526 4412 1341554 SGTC_740 k014-0057 261 µM -1.36341587310722 0.0727557957311712 no 3129 0.0863757406601845 4401 4012779 SGTC_1730 st033808 45.1 µM -1.36457915933843 0.0725803206800171 no 3130 0.0861926793472722 4333 1045166 SGTC_3228 9131799 49.47 µM -1.36916963560869 0.0718910358641128 no 3131 0.0854731275745704 4444 17015818 SGTC_3325 9138760 55.175 µM -1.37228420434985 0.0714262324608739 no 3132 0.0849874904667609 4361 43844959 SGTC_386 1509-0011 3.07 µM -1.37745411384272 0.070659796052066 no 3133 0.0841859461065014 4434 3107280 SGTC_2694 st077685 81.9 µM -1.38043117914848 0.0702213243142723 no 3134 0.0837269628706997 4341 2838096 SGTC_730 1436-0052 41.2 µM -1.38160406893816 0.0700491530938357 no 3135 0.0835466519734134 4458 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1367 1812-0510 76.9 µM -1.3818730320974 0.0700097171796654 no 3136 0.0835053448413491 4480 1142582 YDR527W RBA50 SGTC_1663 st014140 55.4 µM -1.39263383407065 0.0684459185753706 no 3137 0.0818652731286815 4493 4207120 SGTC_3318 9139014 38.6185 µM -1.39780239397082 0.0677044505029585 no 3138 0.0810862076422788 4420 16643984 SGTC_90 0870-0863 4.608 µM -1.40530017033497 0.0666398880856142 no 3139 0.0799660188684339 4450 1738164 SGTC_1190 1486-1332 13 µM -1.4097318894409 0.0660167751400358 no 3140 0.0793094323777113 4442 4150046 SGTC_1241 0364-0022 50.8 µM -1.41144155625893 0.0657776011185731 no 3141 0.0790572284686513 4434 4563895 SGTC_1842 st055362 61.2 µM -1.41152950895355 0.065765315156122 no 3142 0.0790442704490387 4399 676032 SGTC_1080 nisoldipine 24.4 µM -1.41270054874675 0.0656019040558816 no 3143 0.0788718950861224 4453 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_870 0573-2213 57.6 µM -1.41707545455718 0.0649941979110287 no 3144 0.0782304340094554 4431 3916321 SGTC_2294 7971431 200 µM -1.41732154744285 0.0649601440724743 no 3145 0.078194469064155 4426 5741572 SGTC_2047 4141938 200 µM -1.41781171702667 0.0648923566605746 no 3146 0.0781228711945684 4459 3807862 SGTC_1387 3342-1166 1.8 µM -1.4221821681738 0.0642903757376889 no 3147 0.077486686998862 4427 3418228 SGTC_838 0109-0203 71.4 µM -1.42300118362542 0.0641780498863574 no 3148 0.0773679060646801 4472 759422 SGTC_2295 7971645 200 µM -1.42389430328435 0.0640557347772695 no 3149 0.0772385355712281 4502 2978226 YKL099C UTP11 SGTC_1575 cyproterone acetate 48 µM -1.42457649853975 0.0639624284793843 no 3150 0.0771398287392934 4436 9880 An androgen receptor antagonist and liver toxin. SGTC_2378 9074213 121.43 µM -1.42485722453852 0.0639240632831837 no 3151 0.0770992383426529 4416 657714 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.42737664328421 0.0635805494547185 no 3152 0.0767356797467924 4525 4620898 SGTC_777 1315-0167 517 µM -1.42801000110424 0.0634944197036255 no 3153 0.0766444899592616 4471 4221767 SGTC_1075 aripiprazole 15.2 µM -1.42959230495315 0.0632796404501866 no 3154 0.0764170326875295 4506 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1964 st076914 61 µM -1.43431207045189 0.0626423465694283 no 3155 0.0757416136444798 4491 24208661 SGTC_3331 9141060 1.957 µM -1.43792365470073 0.0621580739843925 no 3156 0.0752278585963752 4412 4906567 YPR165W RHO1 SGTC_667 1498-1044 59 µM -1.43966134625715 0.0619261122704741 no 3157 0.0749816171629373 4456 6739982 SGTC_1709 st033179 39.1045 µM -1.44233164166248 0.0615709761357598 no 3158 0.0746044189840422 4462 573381 SGTC_349 k015-0014 24 µM -1.44476234142796 0.0612490896951113 no 3159 0.074262326117628 4478 2196908 SGTC_1839 st053978 48 µM -1.44870350036368 0.0607299762463432 no 3160 0.073710201262701 4508 3788398 SGTC_483 fpl-64176 144 µM -1.44899469798995 0.0606917578077281 no 3161 0.0736695316263136 4590 3423 SGTC_1481 3346-2004 36 µM -1.44943536127915 0.0606339584188786 no 3162 0.073608019739239 4544 2770522 SGTC_3122 9126309 49.47 µM -1.46219231345382 0.0589792927967977 no 3163 0.0718442586981424 4571 17591206 SGTC_1437 4092-1038 11.6 µM -1.46412150613823 0.0587321763890393 no 3164 0.0715803760555911 4534 3977136 SGTC_3159 9100096 49.47 µM -1.46466335507645 0.0586629156208201 no 3165 0.0715063937362965 4412 25236875 SGTC_167 3672-0051 66.205 µM -1.4700522600821 0.0579775743347046 no 3166 0.0707738003045002 4386 3237971 SGTC_2403 6032726 181.2 µM -1.47609552968365 0.0572165158450655 no 3167 0.0699591244036792 4480 2881040 SGTC_207 4185-0010 4.486 µM -1.47731829610406 0.057063487546968 no 3168 0.0697951679255306 4552 3761753 SGTC_1465 k213-0056 144 µM -1.48417016442281 0.0562119345382785 no 3169 0.0688818914065125 4399 24048857 YMR208W ERG12 SGTC_1774 st048371 48.465 µM -1.50153614943383 0.0540985369938074 no 3170 0.0666084720121139 4490 4242727 SGTC_666 0272-0154 136 µM -1.50546668762048 0.0536290394324683 no 3171 0.0661020675617111 4495 6870312 SGTC_232 clozapine 119 µM -1.5056941790842 0.0536019650009402 no 3172 0.0660728494738605 4525 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_289 k017-0060 526 µM -1.50643152844541 0.0535142852920649 no 3173 0.0659782160579755 4486 5512909 SGTC_1094 duloxetine 25.4 µM -1.51451374362271 0.0525606447147156 no 3174 0.0649477953705515 4514 60834 A selective serotonin reuptake inhibitor. SGTC_269 exalamide 29 µM -1.52054546871523 0.0518577748064195 no 3175 0.0641869701027265 4468 3316 A derivative of salicylamide. SGTC_2099 5377090 177.372 µM -1.52299819000376 0.0515741070249647 no 3176 0.0638795791302125 4504 2243829 SGTC_1031 k035-0009 16 µM -1.52321419186714 0.0515491847060664 no 3177 0.0638525633196957 4543 5180959 SGTC_2512 diallyl trisulfide 49.23 µM -1.52517932586225 0.0513228869601595 no 3178 0.0636071878632697 4558 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1843 st055809 45.5 µM -1.52738358154034 0.0510699939387325 no 3179 0.0633328283419438 4537 16413835 SGTC_1341 1486-1360 280 µM -1.52916730856899 0.0508660747584383 no 3180 0.0631114863419884 4502 3976547 SGTC_1016 4226-1401 38 µM -1.53035534496157 0.0507306161455742 no 3181 0.0629643979341132 4511 2901613 SGTC_2979 9012552 45.46 µM -1.53244976034826 0.0504925129499565 no 3182 0.0627057430795202 4522 17100905 SGTC_724 3910-0327 137 µM -1.53450744696174 0.0502594531528844 no 3183 0.0624524313104549 4532 2885483 SGTC_906 1165-0455 526 µM -1.53622805609129 0.0500652307011971 no 3184 0.0622412286348751 4498 3252859 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.53725671586371 0.049949401661862 no 3185 0.0621152282465989 4495 5379071 SGTC_1850 st056238 17 µM -1.54254168925269 0.049357669389465 no 3186 0.0614710076886488 4522 5393177 SGTC_1732 st034308 51.822 µM -1.5430377540275 0.0493024160000468 no 3187 0.0614108079548164 4407 830119 SGTC_1612 st002233 45.4 µM -1.54409707992603 0.0491845900023514 no 3188 0.0612824080838794 4540 1035021 SGTC_1676 st018489 23.4 µM -1.54766547525769 0.0487893407631128 no 3189 0.0608514292288136 4492 3696235 SGTC_741 4582-0002 126 µM -1.54953344151825 0.04858345212773 no 3190 0.0606267694675319 4539 2912688 SGTC_3163 9099914 49.47 µM -1.55542810726422 0.0479382892353951 no 3191 0.0599220721730166 4606 16268368 SGTC_664 1222-0054 14.9 µM -1.55637794350675 0.0478349754929993 no 3192 0.0598091234427322 4497 6813991 SGTC_1694 st024011 44.9 µM -1.55680472478529 0.0477886125492921 no 3193 0.0597584275528151 4569 2787533 SGTC_1459 k035-0031 35.7 µM -1.55741762492957 0.0477220937203018 no 3194 0.0596856821356661 4274 3877128 YMR208W ERG12 SGTC_1069 diphenylcyclopropenone 8.49 µM -1.55864103096128 0.0475895376363343 no 3195 0.0595406829770825 4555 65057 A dermal irritant. YDR527W RBA50 SGTC_1172 0370-0043 85 µM -1.56784312904854 0.0466019177885412 no 3196 0.0584588734022052 4553 376585 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.57154251177771 0.0462095440049434 no 3197 0.0580283439303575 4542 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2352 9027995 87.8 µM -1.57271426122634 0.0460858175175433 no 3198 0.0578924980669897 4489 2997347 SGTC_1488 4013-0813 75.9 µM -1.57426880964609 0.0459220816591469 no 3199 0.057712658674886 4526 2910057 SGTC_706 4262-0057 46.9 µM -1.57473839479493 0.0458727137087763 no 3200 0.0576584207531645 4527 883298 SGTC_307 1501-1223 22.3 µM -1.58335971317882 0.0449739020304575 no 3201 0.0566697499370423 4564 2830329 SGTC_2031 5180455 200 µM -1.58862113243642 0.0444323766824764 no 3202 0.0560729771234448 4536 29949 SGTC_2923 7992654 58.14 µM -1.59045917203548 0.0442444415543941 no 3203 0.0558656707878873 4518 2985126 SGTC_402 epigallocatechin gallate 10 µM -1.59318291154115 0.0439671245231505 no 3204 0.0555595818030631 4506 65064 An antioxidant. SGTC_2712 st079126 47.7 µM -1.59578371932089 0.0437036337240544 no 3205 0.0552685447060537 4543 3152970 SGTC_3078 9116413 49.47 µM -1.59672894835216 0.0436081877482438 no 3206 0.0551630699503311 4492 17177322 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.5992351619449 0.0433559330610641 no 3207 0.0548841800968582 4533 229346 A bile salt which induces apoptosis. SGTC_13 0199-0087 65 µM -1.60117302481705 0.0431616926151683 no 3208 0.0546693008617173 4646 4589825 SGTC_731 3966-0296 387 µM -1.6078424756758 0.0424985509568242 no 3209 0.0539348415265924 4560 660956 SGTC_331 k048-0133 24.5 µM -1.60819737027766 0.0424634960660224 no 3210 0.0538959794730181 4544 6813582 SGTC_615 k087-0205 167 µM -1.61952093720679 0.0413572280729194 no 3211 0.0526676126781542 4568 9642773 SGTC_1474 0330-0125 5.35 µM -1.62542356828244 0.0407898933627625 no 3212 0.0520361687119173 4613 X1474 SGTC_303 1348-1668 34.2 µM -1.62953663053879 0.0403983098011164 no 3213 0.0515997334744311 4571 5380509 SGTC_3134 9127454 49.47 µM -1.62970495471426 0.0403823497636235 no 3214 0.0515819348488309 4599 24262820 SGTC_2607 solasodine 47.35 µM -1.63439145854086 0.0399400402601136 no 3215 0.051088340291761 4514 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2007 4011539 71.82 µM -1.6353674526931 0.0398484236831949 no 3216 0.0509860205420811 4524 45595301 SGTC_2283 7944793 200 µM -1.6459837345204 0.0388628673570539 no 3217 0.0498835539190845 4549 2970533 SGTC_1695 st026914 34.495 µM -1.65706962202366 0.0378549978967624 no 3218 0.0487526999957371 4570 3289191 SGTC_2618 avocadyne 43.43 µM -1.65772035723523 0.0377965055707101 no 3219 0.0486869614635653 4516 3015189 SGTC_2502 avocadyne acetate 18.59 µM -1.6593831546873 0.0376473774907525 no 3220 0.0485193042700451 4517 3952079 SGTC_2356 9061756 188.97 µM -1.66022352910609 0.0375721913978793 no 3221 0.0484347464568087 4599 20104043 SGTC_556 4058-0063 51.5 µM -1.66279855498023 0.03734257368037 no 3222 0.0481763829994386 4600 6615692 SGTC_1674 st016616 23.6 µM -1.66428416901292 0.037210622226062 no 3223 0.0480278272724762 4534 625830 SGTC_2803 7707263 71.43 µM -1.66531212167386 0.0371195432094852 no 3224 0.0479252507062075 4534 2199229 SGTC_2095 5432005 200 µM -1.66898709274494 0.0367954209918132 no 3225 0.0475599689094963 4588 783734 SGTC_1473 k844-0725 134 µM -1.66983205654449 0.0367212257226615 no 3226 0.047476298018292 4608 54682906 SGTC_688 0527-0193 473 µM -1.67031373239984 0.0366789851249739 no 3227 0.0474286538071238 4613 4007154 SGTC_2102 5377816 72.7585 µM -1.67334422938478 0.03641413627076 no 3228 0.0471297750521212 4607 1379702 SGTC_2459 5811157 9.22 µM -1.6747903313712 0.036288307593891 no 3229 0.0469876882825226 4533 2870684 YBR192W RIM2 SGTC_529 4076-0302 30.3 µM -1.68054474605546 0.0357911241411383 no 3230 0.0464256879758684 4566 5816522 SGTC_1173 0443-0020 122 µM -1.68455503653349 0.0354479448820243 no 3231 0.0460372262755485 4577 5331295 SGTC_2868 9035608 32.47 µM -1.6867115916744 0.0352645168797473 no 3232 0.0458294110441782 4567 6462614 SGTC_836 0330-0104 1.35 µM -1.68708574124335 0.0352327726010462 no 3233 0.0457934331911121 4618 46494820 SGTC_1337 1486-1011 40.3 µM -1.69748460856778 0.0343598311566397 no 3234 0.0448025392802045 4589 X1337 SGTC_2332 7982454 138.89 µM -1.69760211090565 0.0343500698154628 no 3235 0.0447914420785983 4484 2981748 SGTC_1166 k206-0078 225 µM -1.70856767070483 0.0334491016023214 no 3236 0.0437655307181655 4605 5404595 SGTC_1218 1348-1416 30.7 µM -1.70900858608014 0.0334132852712072 no 3237 0.0437246795256753 4571 6787668 SGTC_2773 thioridazine 9.09 µM -1.70911818846723 0.033404386978615 no 3238 0.0437145295451053 4573 5452 An antipsychotic. SGTC_2571 chrysanthemic acid 100 µM -1.70951741292242 0.0333719916255994 no 3239 0.0436775745209188 4579 2743 An insecticide. SGTC_1049 3226-0134 66 µM -1.71975706956804 0.032549889354054 no 3240 0.0427383046176191 4611 5702385 SGTC_3296 9122258 64.045 µM -1.72271128640053 0.0323158359294164 no 3241 0.0424703741504005 4579 4730474 SGTC_2112 5488546 200 µM -1.72601005382761 0.0320561279067831 no 3242 0.0421728020136741 4565 600757 SGTC_1816 st051957 91.6 µM -1.72672144653096 0.0320003472984901 no 3243 0.0421088510396087 4609 674121 SGTC_2317 5986382 200 µM -1.73350353681612 0.0314725747690468 no 3244 0.0415031047071541 4623 877883 SGTC_2194 5927483 104.545 µM -1.73739927022301 0.0311726820738804 no 3245 0.0411583599920118 4633 760979 SGTC_1947 st076332 61.6 µM -1.74337468664738 0.0307172922499938 no 3246 0.0406340934951722 4473 24208416 SGTC_231 b-estradiol 524 µM -1.74408486779952 0.0306635370483497 no 3247 0.0405721461456481 4618 450 A steroid. SGTC_1025 k007-0731 70 µM -1.74491977674211 0.0306004405677424 no 3248 0.0404994171592146 4583 6256118 SGTC_1042 0350-0096 82 µM -1.74930295284762 0.0302709529268417 no 3249 0.0401193329132375 4596 3122515 SGTC_244 nsc-207895 1.295 µM -1.75075822973242 0.0301622106359931 no 3250 0.0399937822241783 4422 42640 SGTC_1614 st002383 48.6 µM -1.75170270595177 0.0300918102035175 no 3251 0.0399124706820194 4642 1947235 SGTC_651 3253-0966 34.4 µM -1.75882219836764 0.0295655019774632 no 3252 0.0393038565634435 4627 781462 SGTC_1982 st072467 71.9 µM -1.76253782765845 0.0292938726815237 no 3253 0.0389892354956267 4594 3163533 SGTC_549 1661-1316 519 µM -1.76535750176454 0.0290891277084558 no 3254 0.0387518505476808 4637 2857282 SGTC_1249 0481-0015 10.2 µM -1.76842158396224 0.0288679850171298 no 3255 0.0384952254320433 4561 4227577 SGTC_2354 9060492 162 µM -1.77852585971811 0.0281486141689955 no 3256 0.03765876432301 4609 6471895 SGTC_789 1309-1135 70.6 µM -1.78738511486083 0.0275302208558301 no 3257 0.0369376328794239 4597 3092424 SGTC_926 2268-1401 59.4 µM -1.78896582475151 0.0274210836949663 no 3258 0.0368101597920122 4591 2931578 SGTC_1175 0741-0056 27.6 µM -1.79017863116324 0.0273375925421113 no 3259 0.0367125996017225 4665 765927 SGTC_481 bay k-8644 50 µM -1.7941663240673 0.0270645678903258 no 3260 0.0363933127371485 4590 2303 A calcium channel antagonist. SGTC_1202 1988-0068 29.6 µM -1.79536067600952 0.0269832386146967 no 3261 0.036298126763266 4602 2850480 SGTC_2051 5263410 176 µM -1.80185429364439 0.0265446180090796 no 3262 0.0357841664646077 4587 227584 SGTC_2049 5262831 67.185 µM -1.80359305103964 0.0264281874501582 no 3263 0.0356475631205871 4591 763417 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.80691942994556 0.0262066357860988 no 3264 0.0353874212763549 4572 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2293 7624732 200 µM -1.8086278614263 0.0260934515772197 no 3265 0.0352544185094989 4531 894453 SGTC_637 1181-0519 7.26 µM -1.82294431680941 0.0251609547034947 no 3266 0.0341559124547317 4645 6252091 YGR060W ERG25 SGTC_36 0335-0881 14.2 µM -1.84115359496138 0.0240154049719228 no 3267 0.0327995267585789 4557 23828853 SGTC_962 1254-0300 21.5 µM -1.84869958228427 0.0235536969988646 no 3268 0.0322506020266985 4633 7340576 SGTC_2689 tacrolimus 100 µM -1.85507055162298 0.0231697182266643 no 3269 0.0317930762002251 4620 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1574 spiramycin 23.7 µM -1.86435140569675 0.0226198004812732 no 3270 0.0311361861301229 4628 6419898 An antibiotic and protein synthesis inhibitor. SGTC_405 ebelactone b 50 µM -1.86968966566347 0.0223085068592838 no 3271 0.0307634627232911 4631 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2070 5230947 200 µM -1.87400301224683 0.0220596267672113 no 3272 0.030465004967646 4717 2835538 SGTC_1990 st072050 59.8 µM -1.88372659479091 0.0215071624785985 no 3273 0.0298009835773396 4648 17233948 SGTC_1394 3474-0001 65.7 µM -1.88939348147941 0.0211906143644972 no 3274 0.029419561848312 4651 5017666 YIL048W NEO1 SGTC_1342 1486-1464 234 µM -1.89448933606279 0.0209093377133802 no 3275 0.0290800442532654 4675 3253938 SGTC_2390 9097792 176.6 µM -1.89549569000372 0.0208541651472441 no 3276 0.029013381099523 4675 4497149 SGTC_1904 st060225 78 µM -1.89769599748836 0.0207339642092009 no 3277 0.0288680700681926 4644 66595 SGTC_708 3448-5400 146 µM -1.9049120056423 0.0203438688910391 no 3278 0.0283957551896304 4614 3462195 SGTC_2850 9015429 58.44 µM -1.91706295959787 0.0197010504743955 no 3279 0.0276149668025777 4655 6457570 SGTC_2202 7226349 200 µM -1.92581700038053 0.0192486969016736 no 3280 0.0270636139773716 4691 844334 SGTC_2956 9076196 2.52 µM -1.93526760732041 0.0187702888633131 no 3281 0.026478732592139 4648 16423868 SGTC_246 cycloheximide 667 µM -1.9600755889649 0.01756235179496 no 3282 0.0249934779849541 4659 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2091 4-phenylthiadiazole 200 µM -1.96527873101769 0.0173176005975984 no 3283 0.0246909929424819 4683 270010 SGTC_42 0133-0086 60.653 µM -1.96615271639072 0.0172767762105419 no 3284 0.0246404862402674 4584 162923 Model of phenazepam hydroxylation. SGTC_2990 9074105 71.4286 µM -1.96965373149524 0.0171140649328791 no 3285 0.0244390345464404 4600 6502001 SGTC_521 r062-0005 13.8 µM -1.97003838058948 0.0170962682955007 no 3286 0.0244169860101691 4618 2832033 SGTC_1319 1306-0155 43.7 µM -1.98354397489195 0.0164813523823981 no 3287 0.0236533500709061 4713 3122360 SGTC_1471 k673-0312 37 µM -1.98614905950554 0.0163649457662573 no 3288 0.0235083876004477 4685 24099884 SGTC_401 neomycin 50 µM -1.98767359945001 0.0162971497462811 no 3289 0.0234239002854743 4683 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2405 ticlatone 3.52 µM -1.99413424904559 0.0160125091263434 no 3290 0.0230686926341907 4509 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3301 9125354 19.7965 µM -2.00250811878468 0.0156499260613912 no 3291 0.0226150554039203 4664 41905162 SGTC_202 3594-0513 34.79 µM -2.01778039377532 0.0150067677533434 no 3292 0.0218070688454911 4751 708429 SGTC_1838 st055369 84.5 µM -2.02900834585254 0.014548539176844 no 3293 0.0212287201299533 4673 676036 SGTC_1681 tripelennamine 100 µM -2.03150834025703 0.0144481660361198 no 3294 0.0211017271787379 4627 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_629 3448-6466 76.7 µM -2.03638178608799 0.0142542132663419 no 3295 0.020856016475745 4716 573744 SGTC_1478 0453-0656 35.7 µM -2.05091149922445 0.013689216059961 no 3296 0.0201377830502528 4732 5258496 SGTC_3220 9131269 49.47 µM -2.05408696370405 0.0135683417622623 no 3297 0.0199836377813318 4706 17722206 SGTC_633 0437-0093 97.7 µM -2.06272696474957 0.0132441118104897 no 3298 0.0195692882472496 4654 2831118 SGTC_233 rapamycin 362 pM -2.07808428122928 0.0126843087291889 no 3299 0.0188507985799496 4708 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_342 k048-0088 23.3 µM -2.09010620578315 0.0122604884721209 no 3300 0.0183041301724803 4717 6820570 SGTC_1684 st024538 14.6195 µM -2.10950877767327 0.0116023450495255 no 3301 0.017450344581525 4715 6732859 SGTC_2759 disulfiram 3.38 µM -2.1142196719272 0.0114472562797952 no 3302 0.0172482547223257 4619 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_614 0462-0418 107 µM -2.1269668654746 0.0110365990279827 no 3303 0.0167114181846926 4535 5188303 SGTC_909 3448-9333 149 µM -2.13501827130339 0.0107838740628439 no 3304 0.0163797588437895 4659 3344074 SGTC_2626 ethyl orsellinate 100 µM -2.14163452110836 0.0105799830597004 no 3305 0.01611145177919 4662 75653 A natural product. SGTC_1943 st076331 65.2 µM -2.14286638925584 0.0105423940596781 no 3306 0.0160619142621452 4690 24208415 SGTC_43 0570-0105 72.5 µM -2.15617889042772 0.0101435443960347 no 3307 0.0155348496094461 4689 1114046 YDL195W SEC31 SGTC_613 3914-0030 117 µM -2.16441974988335 0.00990329601939004 no 3308 0.0152160747171876 4529 1145395 SGTC_1195 1502-0147 41.1 µM -2.17444045146623 0.00961786521260752 no 3309 0.0148360364754936 4726 817940 SGTC_1227 3909-8010 46.6 µM -2.18468623423643 0.00933348336563227 no 3310 0.0144559300990997 4729 15982272 SGTC_3356 9151811 4.48 µM -2.19511327206204 0.00905165066830421 no 3311 0.0140777367011793 4745 1859254 YPR165W RHO1 SGTC_2087 5276107 200 µM -2.21174035001185 0.00861764554771714 no 3312 0.0134923053871768 4720 144405 SGTC_317 4495-0002 170 µM -2.22721675834727 0.00823018852565957 no 3313 0.0129663953203658 4733 15991618 SGTC_2017 5132927 60.65 µM -2.228811483452 0.00819114723175013 no 3314 0.0129132252804832 4694 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1564 D-Arginine 115 µM -2.24629956221505 0.00777357232248308 no 3315 0.0123424132980647 4709 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2793 7325131 81.82 µM -2.25603705194677 0.00754927867061505 no 3316 0.012034155388978 4706 4176441 SGTC_1926 methyl fluorone black 53.6 µM -2.26471810514012 0.0073541451095151 no 3317 0.0117649918605715 4445 72721 Reacts with homocysteine. SGTC_1128 3448-9350 235 µM -2.27638577209511 0.00709888732532918 no 3318 0.0114114652460055 4684 619386 SGTC_833 3852-0053 558 µM -2.28225790103982 0.0069734027445073 no 3319 0.0112370592299967 4744 3123681 SGTC_2256 7954252 200 µM -2.29136820072753 0.00678259430090579 no 3320 0.0109710635641721 4744 2972920 SGTC_2992 9074591 71.4286 µM -2.35681883033849 0.00554221842775218 no 3321 0.00921611851389208 4703 17741321 SGTC_2319 6033012 152.6 µM -2.36028315033481 0.00548257619965092 no 3322 0.00913049550824827 4719 847246 SGTC_2349 9023730 187.07 µM -2.40554072017235 0.00475419069341162 no 3323 0.00807427608586198 4750 4126287 SGTC_970 1315-0089 19.5 µM -2.41765912576191 0.00457441153725632 no 3324 0.00781035120010187 4754 6811083 YLR033W RSC58 SGTC_2922 7999257 32.47 µM -2.4194026298111 0.00454905186917012 no 3325 0.00777301107583249 4725 2988377 SGTC_203 k066-0004 30.888 µM -2.41978762551525 0.00454346896411122 no 3326 0.00776478693870969 4767 6795412 SGTC_677 0929-0063 136 µM -2.43236089014181 0.0043644707956203 no 3327 0.00750037626401632 4777 1539583 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -2.45850784532665 0.00401227467219968 no 3328 0.0069757864111925 4730 364106 SGTC_338 4055-0136 114 µM -2.46347430073519 0.00394832835803786 no 3329 0.00687988796303204 4752 2900563 SGTC_1608 st001473 40.5 µM -2.46578077411622 0.00391894264115844 no 3330 0.00683574899131807 4746 7292267 SGTC_3008 9078912 71.4286 µM -2.51093950625637 0.00338172269773053 no 3331 0.0060205164547281 4762 16648731 SGTC_1038 k292-0204 154 µM -2.60091604649202 0.0025041758155068 no 3332 0.00464876019981879 4734 4454212 SGTC_681 1642-0006 26.6 µM -2.63763246055446 0.00220959601479139 no 3333 0.00417435064391207 4774 4446530 SGTC_247 mechlorethamine 29.705 µM -2.64908846617677 0.0021243319970281 no 3334 0.00403546007937596 4787 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3351 9150312 21.596 µM -2.65844967695264 0.00205688664533242 no 3335 0.00392505365712522 4750 4904905 SGTC_3005 9076496 71.4286 µM -2.68018506405937 0.00190771980441901 no 3336 0.00367907337605524 4771 21368410 SGTC_1992 st073643 23.3 µM -2.68160763358484 0.00189830842679242 no 3337 0.003663467002184 4774 3161292 SGTC_2059 5238311 157 µM -2.71890390952765 0.00166613505107622 no 3338 0.00327493163609592 4758 703021 SGTC_1046 2001-0062 216 µM -2.73742200801602 0.00156074329248506 no 3339 0.00309614005321558 4772 739778 SGTC_166 k072-0058 166.424 µM -2.76062377914539 0.00143728408681468 no 3340 0.00288455459027403 4716 5846229 SGTC_3307 9126885 69.2785 µM -2.82111120918822 0.00115617378420657 no 3341 0.00239288045363463 4759 24824909 SGTC_1303 1160-0052 261 µM -2.82413945019314 0.00114352271090226 no 3342 0.00237038767166219 4766 3562476 SGTC_1915 st067105 30.6 µM -2.82505338305349 0.00113972956189719 no 3343 0.00236363697058306 4747 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2053 5265679 138 µM -2.86897304439429 0.000970473588373889 yes 3344 0.00205903446295173 4759 764595 SGTC_2614 arthonioic acid 13.39 µM -2.87804744921334 0.000938517449360495 yes 3345 0.00200072473912968 4721 6710684 SGTC_3348 9149464 3.537 µM -2.93739896426544 0.00075223423184896 yes 3346 0.00165489000547985 4779 1951442 SGTC_3355 9151058 44.0485 µM -2.93990753290572 0.000745168087173437 yes 3347 0.00164155103825825 4788 17015728 SGTC_818 4072-2707 53.5 µM -2.9633410149138 0.000682053298516891 yes 3348 0.00152159610488047 4776 882871 SGTC_250 brefeldin a 552.239 µM -3.01716503926764 0.000555300989628743 yes 3349 0.00127575427142507 4804 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2258 7960471 200 µM -3.16037062779059 0.000316310317128755 yes 3350 0.000787842816032798 4793 2974708 SGTC_1986 st071812 45 µM -3.23844819364195 0.000230489015433905 yes 3351 0.000600909227515462 4788 11838594 SGTC_750 4073-0104 132 µM -3.35746450340016 0.000140405279746724 yes 3352 0.000393304214218232 4691 22330957 SGTC_1174 0739-0097 51.1 µM -3.42110092830931 0.000107013579762492 yes 3353 0.000311840911109171 4806 728447 SGTC_1107 amlodipine 47 µM -3.50834868208428 7.31988508400736e-05 yes 3354 0.000225448828410522 4560 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2755 lomerizine 42.69 µM -3.75929480798708 2.34009528718024e-05 yes 3355 8.51964803201607e-05 4792 3949 A calcium channel blocker. SGTC_630 4356-0227 183 µM -4.0894079721414 4.68073817083806e-06 yes 3356 2.16237804786096e-05 4805 779312