SGTCid condition conc unit PRP19|YLL036C.score PRP19|YLL036C.strain.pval PRP19|YLL036C.strain.significant PRP19|YLL036C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_3037 9091026 49.47 µM 12.3558931898336 1.97719255565391e-38 yes 1 2.26349962743691e-35 3 25236398 YIL048W NEO1 SGTC_341 1486-1430 230 µM 8.90651150893552 7.0096272934893e-21 yes 2 2.63317497679447e-19 3 2054753 YPL210C SRP72 SGTC_2328 6201408 200 µM 6.3267036141144 2.04996964252732e-11 yes 3 1.25226875527255e-10 2 2890418 SGTC_2327 6189656 200 µM 5.99108769684733 2.06283029034094e-10 yes 4 1.04221097058539e-09 2 5349088 SGTC_202 3594-0513 34.79 µM 5.42808781283596 7.56786073095906e-09 yes 5 2.84805074210653e-08 4 708429 SGTC_836 0330-0104 1.35 µM 5.40215446945993 8.86130982739936e-09 yes 6 3.29226046291138e-08 1 46494820 SGTC_221 trifluoperazine 10.304 µM 5.1542347557965 3.86263184014848e-08 yes 7 1.27334373066399e-07 20 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_971 1315-0384 26.7 µM 4.78143167640433 3.12558191399836e-07 yes 8 8.70255798206405e-07 3 6769120 SGTC_2567 aureobasidin a 60 nM 4.62592780034069 7.1579106182966e-07 yes 9 1.864626005407e-06 33 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1381 2324-0066 62.1 µM 4.35340678569716 2.87522330251515e-06 yes 10 6.7019051160645e-06 6 10885928 SGTC_523 1934-0222 13.7 µM 4.23303408490389 5.18303906451018e-06 yes 11 1.1527977284443e-05 3 1361595 SGTC_3152 9099253 49.47 µM 4.22632586700094 5.35366837459256e-06 yes 12 1.18768965873547e-05 24 25236131 SGTC_1704 st028805 70.8 µM 4.12206997750696 8.80307779544647e-06 yes 13 1.87741546939536e-05 2 2876101 SGTC_874 0599-0792 117 µM 4.05745919709238 1.19124093477262e-05 yes 14 2.4804740505182e-05 4 765305 SGTC_1844 rapamycin 4 nM 3.94068594877846 2.03516930666476e-05 yes 15 4.06244701808768e-05 52 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1151 3909-8316 15.3 µM 3.84161054508819 3.17023283102389e-05 yes 16 6.11148328360584e-05 7 800431 SGTC_1084 voriconazole 435 nM 3.76664830696842 4.40326528134932e-05 yes 17 8.27269075290851e-05 12 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_855 0428-0020 25 µM 3.71358874800618 5.53644389631825e-05 yes 18 0.000102170380011771 11 6812414 SGTC_1800 st050079 29.0735 µM 3.67382751620321 6.56032946026837e-05 yes 19 0.000119472030210781 32 3645560 SGTC_2985 9022375 71.43 µM 3.66737198934135 6.74253343191816e-05 yes 20 0.000122528081864561 9 4939335 SGTC_81 0411-0046 9.971 µM 3.60008565997339 8.94768397005272e-05 yes 21 0.000159056182735558 45 12925265 SGTC_1149 3909-7961 23.3 µM 3.55026762774363 0.000109996556336851 yes 22 0.00019241985491843 8 735261 SGTC_2884 9058502 51.95 µM 3.53197326919181 0.000118584151363888 yes 23 0.000206235523872276 3 6471554 SGTC_974 1326-0144 138 µM 3.50625776403777 0.000131723391776602 yes 24 0.000227227441827355 13 5411856 SGTC_3137 9097352 49.47 µM 3.46887762770344 0.000153274221803575 yes 25 0.000261318726199371 12 44120435 SGTC_382 3229-0966 23.2 µM 3.45302285214867 0.000163377024591105 yes 26 0.000277171019795556 7 5722370 SGTC_1781 st038725 66.3 µM 3.41816619870803 0.000187819253205604 yes 27 0.00031522298483274 15 4270275 YIL048W NEO1 SGTC_2916 7875993 68.79 µM 3.36474418028798 0.000231995713796459 yes 28 0.000383073291619887 12 1299250 SGTC_427 1354-0053 47.3 µM 3.30018151200475 0.000298292989592236 yes 29 0.000483111569067481 8 6813657 SGTC_2758 dehydroepiandrosterone 69.35 µM 3.27118377602433 0.000333476346421172 yes 30 0.000535491443937853 17 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2972 9093619 59.92 µM 3.24596895525516 0.000367167546613001 yes 31 0.000585258015581869 12 25236256 SGTC_1815 st051655 58.2 µM 3.16914778043943 0.000490299231595358 yes 32 0.000764433189439214 25 5984156 SGTC_1224 0823-0416 294 µM 3.16086569957612 0.000505643552359543 yes 33 0.000786505037076326 7 3598164 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 3.14620545880066 0.000533899349126891 yes 34 0.000827018836428934 26 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_563 tetrahydrosecaminediol 614 µM 3.14426752833268 0.0005377418851954 yes 35 0.000832515726395359 9 334274 A psychoactive constituent of the cannabis plant. SGTC_1818 st052136 56.3 µM 3.10414274046131 0.000623279572795206 yes 36 0.000954156199743042 30 674169 SGTC_773 4358-1457 44.6 µM 3.08917708952196 0.000658279811161387 yes 37 0.00100355880807962 16 1186886 SGTC_15 0266-0086 27.098 µM 3.08488868906024 0.000668638385676225 yes 38 0.00101814172927312 21 1712902 YIL048W NEO1 SGTC_3219 9131112 49.47 µM 3.08265335300302 0.000674097238808512 yes 39 0.00102581995304201 30 17612988 YMR079W SEC14 SGTC_1786 berberine 21.6 µM 3.07318388064258 0.000697681433987385 yes 40 0.00105893971320282 28 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_649 1123-0311 367 µM 3.05636755204484 0.000741447572631062 yes 41 0.00112018218259643 24 693629 YIL048W NEO1 SGTC_896 0964-0007 44.5 µM 3.01395797631582 0.000863296284659466 yes 42 0.00128931760594314 19 6756758 SGTC_3153 9100258 49.47 µM 3.00707345383856 0.000884731424636212 yes 43 0.00131888008644903 10 25236848 SGTC_1234 0326-0494 15.5 µM 2.95785138747071 0.00105281992817884 no 44 0.00154895719553652 16 1547813 SGTC_3 0833-0587 95.581 µM 2.93160982803971 0.00115395516193473 no 45 0.0016860505421986 32 5382644 SGTC_2108 5365811 200 µM 2.9281114682371 0.00116809032182059 no 46 0.00170513879549625 16 780283 SGTC_1880 MG-132 525 µM 2.90734377611634 0.00125531755855215 no 47 0.00182256182284146 32 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1837 st055472 66.5 µM 2.86690028080611 0.00144250077484206 no 48 0.00207256799515218 11 676091 SGTC_232 clozapine 119 µM 2.86387407753468 0.0014574834578486 no 49 0.00209247171103191 11 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_970 1315-0089 19.5 µM 2.86148495256287 0.00146941215478008 no 50 0.00210830759706201 21 6811083 YLR033W RSC58 SGTC_516 3992-2719 87.3 µM 2.85606022272339 0.00149682887127296 no 51 0.00214466883391241 13 5350887 YDR037W KRS1 SGTC_1813 st051246 8.6015 µM 2.85280572686852 0.00151350033840728 no 52 0.00216675526576851 8 5291959 SGTC_2698 st077697 67.5 µM 2.85245093777226 0.00151532798078291 no 53 0.00216917544311453 20 3154499 SGTC_1080 nisoldipine 24.4 µM 2.84387496223195 0.00156012282257826 no 54 0.00222842671211772 24 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2741 miltefosine 3.04 µM 2.83553303747318 0.00160485018157754 no 55 0.00228746415100918 10 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_961 1252-1571 372 µM 2.8172365040095 0.00170707090794191 no 56 0.00242194212155106 26 6813498 SGTC_1275 0867-0008 21.1 µM 2.80639668845762 0.00177039323247756 no 57 0.00250494873235639 15 3422836 SGTC_1247 0448-0043 5.84 µM 2.7890992865473 0.00187587546984672 no 58 0.00264274293249054 28 3089013 YGL099W LSG1 SGTC_3131 9127911 49.47 µM 2.78260283302832 0.00191694533950102 no 59 0.00269623867046667 18 45595681 SGTC_2721 ifenprodil 61.44 µM 2.77125344246679 0.00199065986770779 no 60 0.00279204721491867 20 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2936 9038235 15.59 µM 2.75124374747793 0.00212691861671577 no 61 0.00296847246249446 31 4749415 SGTC_180 1486-1293 102.781 µM 2.74863696722522 0.00214527924526654 no 62 0.00299218131399446 21 4140536 SGTC_459 nigericin 15.3 µM 2.71990742100137 0.00235736686426048 no 63 0.00326500979249531 24 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3179 9107801 49.47 µM 2.70630061331849 0.00246429153475135 no 64 0.00340187127584929 16 4818259 SGTC_2443 5493264 126.67 µM 2.69443937727839 0.00256105700101927 no 65 0.00352535757116134 19 5340055 SGTC_1064 honokiol 6.76 µM 2.69207693205361 0.00258073539852094 no 66 0.00355042816630205 30 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_336 4111-0029 111 µM 2.67932344442177 0.00268934687278103 no 67 0.0036885547965289 9 3131175 SGTC_4 0960-0234 25.671 µM 2.64912680156501 0.00296314229102089 no 68 0.00403500233789957 27 6821112 SGTC_1980 st071811 45.7 µM 2.63928449813163 0.00305766646396361 no 69 0.00415406131108569 16 4974850 SGTC_492 tmb-8 126 µM 2.63010697398803 0.00314824390067861 no 70 0.00426790020684217 18 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1009 4106-0057 9.87 µM 2.61452379950792 0.00330758686833862 no 71 0.00446759676063477 28 2928005 SGTC_2697 mebhydrolin 72.4 µM 2.6041908948273 0.0034172051788293 no 72 0.00460457240569168 22 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_652 0437-0092 114 µM 2.60028115386802 0.00345952627205087 no 73 0.00465737051489944 9 3091274 SGTC_945 3381-0768 11.3 µM 2.56728529175746 0.00383587136333096 no 74 0.00512491219032127 25 1126236 YIL048W NEO1 SGTC_1820 st053765 18.6 µM 2.53840052402389 0.00419501543598015 no 75 0.00556802281387681 14 3690829 SGTC_3028 9087778 49.47 µM 2.53551120271523 0.0042325454745882 no 76 0.00561416685088122 18 17217395 SGTC_1700 st030840 7.9285 µM 2.51986154284865 0.00444108763184926 no 77 0.00587005021270772 35 5499307 SGTC_259 usnic acid 108.925 µM 2.51217573038323 0.00454682859721996 no 78 0.00599946608922159 32 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_817 1391-0715 46 µM 2.49528891729768 0.00478708745267681 no 79 0.00629273049106327 40 1353946 SGTC_1067 clotrimazole 1.36 µM 2.49059892378224 0.00485579318851636 no 80 0.00637639944847021 45 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_833 3852-0053 558 µM 2.48636014730043 0.00491864357397678 no 81 0.00645286421723004 29 3123681 SGTC_1053 3366-3204 134 µM 2.46434548771743 0.00525686768624753 no 82 0.00686318656763064 39 3632071 YPR165W RHO1 SGTC_361 000s-0510 1.45 µM 2.44833194707717 0.00551573494271077 no 83 0.00717596818350111 30 660 SGTC_942 3253-1115 227 µM 2.43494962409376 0.00574069004737877 no 84 0.0074469315306032 39 46497897 SGTC_1055 3448-0672 86 µM 2.432726706034 0.0057788355347145 no 85 0.00749280350847391 47 748378 SGTC_1156 4092-0367 4.88 µM 2.4253965018885 0.00590622114703079 no 86 0.00764583763489385 36 1357585 SGTC_1631 benzylvanillin 81.9 µM 2.41688910885443 0.00605718147957492 no 87 0.00782689261086049 31 75506 SGTC_3334 9142812 21.919 µM 2.40836162219672 0.00621192024019178 no 88 0.0080121498693779 33 45283678 SGTC_2056 5235370 200 µM 2.40032995897389 0.00636085295230735 no 89 0.00819014957351064 30 5511916 SGTC_2634 4'-methoxyflavone 100 µM 2.39576101754988 0.00644697857552064 no 90 0.00829295018878588 30 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3075 9116269 49.47 µM 2.39325869672221 0.0064945838433342 no 91 0.00834973096861338 33 17015205 YNL244C SUI1 SGTC_285 1486-1325 46 µM 2.38013859034951 0.00674931092366219 no 92 0.00865306393852246 37 22310230 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.3771660076941 0.0068082358093858 no 93 0.00872311722843012 34 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1089 terbinafine 2.25 µM 2.36565023821649 0.00704082306338132 no 94 0.00899921951632654 27 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_309 k408-0051 1.48 µM 2.35146353803984 0.00733697661023195 no 95 0.00934986111994228 72 3640463 SGTC_1816 st051957 91.6 µM 2.34662030441944 0.00744056641384445 no 96 0.00947227463592991 18 674121 SGTC_2576 guaiol 23.12 µM 2.33126164240964 0.00777763838529286 no 97 0.00986978374988338 44 227829 SGTC_286 k060-0067 22.9 µM 2.32535099222204 0.00791089528255038 no 98 0.0100265998634605 41 5985051 SGTC_882 0843-0131 351 µM 2.32341212264501 0.00795504278299812 no 99 0.0100785117470119 48 5425421 SGTC_1465 k213-0056 144 µM 2.32053805135451 0.00802088313407029 no 100 0.0101558944823143 48 24048857 YMR208W ERG12 SGTC_756 0508-1999 28.3 µM 2.32021049057109 0.00802841735125622 no 101 0.0101647466887598 42 6753853 SGTC_2799 7812892 81.82 µM 2.31646792879456 0.00811494253837582 no 102 0.0102663667833783 62 20205235 SGTC_1162 k048-0130 20.1 µM 2.31034736955151 0.00825821179718763 no 103 0.0104344651854934 40 6797406 SGTC_1571 st070080 73.4 µM 2.30937604244571 0.00828115159653124 no 104 0.0104613616372661 30 4315245 SGTC_2700 st077718 96.8 µM 2.29367057841356 0.00865991184866753 no 105 0.0109047139812026 31 904970 SGTC_2080 5212524 12.4 µM 2.29063091945136 0.00873494755498407 no 106 0.010992384543659 35 260183 SGTC_1875 nocodazole 6 µM 2.27877967831354 0.0090329731096586 no 107 0.0113400827529944 47 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1689 st020265 53.493 µM 2.27085899535534 0.00923708699116179 no 108 0.0115777576082986 33 5758320 YPR016C TIF6 SGTC_524 r073-0010 27.8 µM 2.26424915239245 0.00941049926234636 no 109 0.01177939751019 55 2772106 SGTC_2331 7980721 200 µM 2.25584496177899 0.00963509422130019 no 110 0.0120401712016356 47 2981221 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 2.25537706915202 0.00964773478691309 no 111 0.0120548354114359 34 676296 Flavone; oxidizing agent. SGTC_671 0560-0003 407 µM 2.25222567167396 0.0097332509392106 no 112 0.0121540072534753 22 3238678 SGTC_2257 7960413 200 µM 2.24889412078803 0.0098243751087771 no 113 0.0122596165739594 54 2974689 YIL048W NEO1 SGTC_968 1309-0633 340 µM 2.24769987685853 0.00985722086683957 no 114 0.0122976669352513 36 3761976 SGTC_2742 clothiapine 36.27 µM 2.24653906360333 0.0098892390356892 no 115 0.0123347501656994 21 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2101 5377231 179.231 µM 2.23956155448454 0.0100836165043372 no 116 0.0125597004844607 33 2844213 SGTC_3232 9132874 49.47 µM 2.23531968990579 0.0102034076163454 no 117 0.0126981841543958 41 3784940 SGTC_1276 0871-0068 94.2 µM 2.23062561287022 0.0103374143861971 no 118 0.0128529693751342 43 3414906 SGTC_1388 3346-4487 254 µM 2.2293782739368 0.0103732805176541 no 119 0.0128943732759237 27 3345614 SGTC_330 1488-0319 80.1 µM 2.21094180279732 0.0109161942135938 no 120 0.0135199336976002 47 6846614 SGTC_2363 9053361 176 µM 2.1943070585672 0.0114271035472619 no 121 0.0141066711765822 48 6469797 YMR079W SEC14 SGTC_234 nsc-17383 10.7 µM 2.17781468995297 0.0119540212853599 no 122 0.0147099178947742 43 408974 SGTC_364 0083-0097 67.7 µM 2.17393939886239 0.0120808484015918 no 123 0.0148548433352453 43 5207356 SGTC_3107 9121808 49.47 µM 2.16620001961916 0.0123376309177074 no 124 0.0151479528221732 31 662681 SGTC_2570 licareol 100 µM 2.16011288343168 0.0125429031406925 no 125 0.0153819659538268 49 443158 SGTC_2515 chrysin 20.77 µM 2.15418467143193 0.0127456514320511 no 126 0.0156128462369165 31 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2929 9013348 24.6 µM 2.14335343183835 0.0131234157140757 no 127 0.0160423646975343 34 2995952 SGTC_2246 7293507 91.5585 µM 2.14267304424971 0.0131474654852309 no 128 0.016069680661337 55 887656 SGTC_2060 5238662 140 µM 2.13168190232596 0.0135412807043883 no 129 0.0165165027911227 31 790130 SGTC_600 1495-0418 41.6 µM 2.12881877112885 0.0136455238925254 no 130 0.0166346286380763 53 5377768 SGTC_595 3909-8003 73.7 µM 2.12810633167999 0.0136715702971063 no 131 0.0166641342373016 50 699517 SGTC_343 4130-2827 29.8 µM 2.12194361895148 0.0138986717024617 no 132 0.0169212364691302 36 1118244 SGTC_1502 4534-4282 27.7 µM 2.10424044091729 0.014569228653339 no 133 0.0176787392466256 27 3278949 SGTC_568 1193-0097 7.48 µM 2.09475001638151 0.0149400356315281 no 134 0.0180966102472864 75 3646150 SGTC_250 brefeldin a 552.239 µM 2.08473360201784 0.0153401657757559 no 135 0.0185467443705811 18 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_477 mead ethanolamide 10 µM 2.07837969470042 0.0155987302211871 no 136 0.0188372007073629 5 16061185 SGTC_2172 5754775 163.918 µM 2.07810656016794 0.0156099284330028 no 137 0.0188497727900436 60 2263357 SGTC_2147 5545932 89.7195 µM 2.07056146527604 0.0159220076475094 no 138 0.0191998982162775 56 797404 SGTC_894 0960-0238 55.9 µM 2.06658257921663 0.0160887254376439 no 139 0.0193867518678782 52 6741907 YDL195W SEC31 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.0647416345058 0.0161663669800543 no 140 0.019473726466565 61 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2881 9058953 51.95 µM 2.05689086096743 0.0165010858744691 no 141 0.0198483626388171 52 17122249 SGTC_1327 1436-0082 2.18 µM 2.05350602914487 0.0166472187552951 no 142 0.0200117628022249 47 15992205 SGTC_1835 st008666 49.2 µM 2.0485181297968 0.0168645781943783 no 143 0.0202546287518795 30 690455 SGTC_1320 1313-0481 95.3 µM 2.04404054854839 0.0170617620743695 no 144 0.0204747707627478 30 6813365 YLR208W SEC13 SGTC_46 0329-0187a 2.197 µM 2.03899532989744 0.0172863015233212 no 145 0.0207252468235814 59 46494817 SGTC_1995 st072814 61.1 µM 2.01041408068559 0.0186065297906283 no 146 0.022193690716481 37 5769371 SGTC_925 2064-1272 59.6 µM 2.00853969968331 0.0186960329354145 no 147 0.0222929858912301 60 6815817 SGTC_2688 kanamycin b 96.69 µM 2.00138230930079 0.0190411826002609 no 148 0.0226756028265281 84 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2811 7967822 32.47 µM 1.9960507455339 0.0193017938880825 no 149 0.0229641997537829 50 2232244 SGTC_598 3937-0236 20.2 µM 1.99183247747058 0.0195101285018459 no 150 0.0231947207640892 49 1379313 SGTC_809 3998-0021 90 µM 1.99118102937842 0.0195424722994024 no 151 0.0232304943452229 66 715485 SGTC_2905 7799065 20.05 µM 1.96983827681826 0.0206275878740076 no 152 0.0244284541076727 63 1296806 SGTC_2588 indole-3-carbinol 100 µM 1.96137651770738 0.021071715474568 no 153 0.0249175586006147 51 3712 Induces cell cycle arrest. SGTC_2679 rapamycin 1 nM 1.95756188528599 0.0212745625139163 no 154 0.0251407217243928 117 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1237 0330-0133 46.1 µM 1.95509086317869 0.021406841087107 no 155 0.0252861732534482 68 X1237 YHR072W ERG7 SGTC_1803 st050068 52.4 µM 1.94222961292384 0.0221066082831717 no 156 0.0260546548362961 66 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2505 galangin 7.89 µM 1.94023015951679 0.0222171118280575 no 157 0.0261758623805572 63 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3322 9139058 2.11 µM 1.93934682794935 0.0222660790423428 no 158 0.0262295602050033 61 4908926 YPR165W RHO1 SGTC_302 1094-0063 18.9 µM 1.93751536502675 0.0223678957868147 no 159 0.0263411885083495 80 5440289 SGTC_1088 bifonazole 369 nM 1.93452262004878 0.0225351169181583 no 160 0.0265244518274329 42 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_468 gf-109203x 121 µM 1.93350017695968 0.0225924874791098 no 161 0.0265873056509751 22 2396 A protein kinase C inhibitor. SGTC_3240 9133527 49.47 µM 1.93183827162159 0.0226860017797512 no 162 0.0266897353431761 42 17617455 SGTC_650 1328-0195 38 µM 1.92879709171263 0.0228579717570134 no 163 0.0268780285179246 51 2780821 SGTC_554 4483-2211 187 µM 1.91626889081058 0.0235780309400662 no 164 0.027665439245063 35 747107 SGTC_271 rotenone 740 µM 1.91480111156217 0.0236636269104482 no 165 0.0277589363393007 41 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2816 7982706 58.44 µM 1.89495293248941 0.0248469945454671 no 166 0.029049318787786 73 2981853 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.89230844912197 0.0250083457213214 no 167 0.0292249479298805 43 2374 Ca(2+)-ATPase inhibitor. SGTC_827 3253-0474 693 µM 1.89149081867224 0.0250584102641925 no 168 0.0292794277242743 70 5402065 SGTC_3085 9117376 49.47 µM 1.88999922549263 0.0251499588345966 no 169 0.0293790318325999 60 16480349 SGTC_1117 retinoic acid 1.10837 µM 1.88835584651025 0.0252511478503299 no 170 0.0294890973312566 45 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_49 0717-0965 32.132 µM 1.88495087722523 0.0254618904786514 no 171 0.0297182351032958 63 5889349 YGL099W LSG1 SGTC_780 0109-0199 192 µM 1.88242074289065 0.0256194394815934 no 172 0.0298894558615735 66 610414 SGTC_1748 st037455 53.6035 µM 1.88222210289799 0.0256318430790172 no 173 0.0299029329165176 73 580690 SGTC_2319 6033012 152.6 µM 1.88049193941606 0.0257400917280083 no 174 0.0300205319532366 54 847246 SGTC_2636 apigenin dimethyl ether 100 µM 1.87901226071957 0.0258329719576252 no 175 0.0301214095597489 60 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2019 4016004 108 µM 1.87875579168647 0.0258490991409296 no 176 0.0301389229686495 72 45595336 SGTC_421 streptovitacin 30 mM 1.87771719852768 0.0259144937028641 no 177 0.0302099313387663 46 91467 include heat shock SGTC_1734 st037168 69.4 µM 1.87320844858267 0.0261999920190875 no 178 0.0305198030626244 69 708907 SGTC_3013 9080133 71.4286 µM 1.87225057388205 0.0262609830497693 no 179 0.0305859726285668 47 17050193 SGTC_2024 5144227 134 µM 1.87212022677537 0.0262692918463834 no 180 0.0305949861274138 52 3475211 SGTC_3010 9080089 71.4286 µM 1.85934298978519 0.0270944921132296 no 181 0.0314892685485302 44 17027233 SGTC_1557 sumaresinolic acid 42.3 µM 1.85615484955985 0.0273037326353099 no 182 0.0317157447808731 38 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3106 9121286 49.47 µM 1.85142068631336 0.027616925375389 no 183 0.0320545276747502 51 15943471 SGTC_934 2950-0684 338 µM 1.84699988907962 0.0279120852316842 no 184 0.0323735781824024 65 1121253 SGTC_653 0203-0016 55.2 µM 1.8426633723097 0.0282041663709717 no 185 0.0326890874937283 58 295302 SGTC_2903 5923464 63.88 µM 1.83432185631601 0.0287731551230839 no 186 0.0333031158274675 56 2876576 SGTC_424 splitomicin 100 mM 1.82143519195651 0.0296709141554352 no 187 0.0342703648678523 56 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2525 harmine 47.85 µM 1.81826169996614 0.0298955297026169 no 188 0.0345120718291295 49 5280953 A monoamine oxidase inhibitor SGTC_1341 1486-1360 280 µM 1.81237481980944 0.030315929931643 no 189 0.0349641504209628 64 3976547 SGTC_2518 prenyletin 46.28 µM 1.80795340063101 0.0306348886782609 no 190 0.0353068767564254 33 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2791 5663188 71.43 µM 1.80548557197569 0.0308141216658367 no 191 0.035499365628827 86 54690634 SGTC_1138 3761-0006 1.03 µM 1.79623006855558 0.0314940782634134 no 192 0.0362289672396831 36 12061087 SGTC_3246 9135460 32.98 µM 1.79448993495679 0.0316232925014338 no 193 0.0363675018446167 58 41446951 SGTC_2322 7413319 38.22 µM 1.79344993587553 0.0317007269553599 no 194 0.0364505045009174 90 1840400 SGTC_1061 3448-9325 110 µM 1.7925693193318 0.0317664168156825 no 195 0.0365209079360206 72 723482 SGTC_708 3448-5400 146 µM 1.78883561119123 0.0320461843411879 no 196 0.0368206469813894 108 3462195 SGTC_408 cantharidin 100 µM 1.78728844630311 0.032162708399799 no 197 0.0369454402113352 64 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1738 st035555 74 µM 1.77733382079053 0.0329208284006533 no 198 0.0377566661137376 75 5331140 SGTC_1921 5740136 50 µM 1.77708881327724 0.032939671711846 no 199 0.0377768142202841 56 1774243 SGTC_1688 st021091 57.6 µM 1.77653004176365 0.0329826795902098 no 200 0.0378227974276357 64 3656366 SGTC_322 k048-0136 19.3 µM 1.77551936533341 0.0330605875167229 no 201 0.0379060854544603 76 6823282 SGTC_2743 auranofin 4.32 µM 1.77509629192216 0.0330932450940416 no 202 0.0379409945793325 48 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2951 9072950 58.06 µM 1.77267477043824 0.0332806772333006 no 203 0.0381413070271024 63 16488155 SGTC_807 1315-0151 48 µM 1.77094592871568 0.0334150283650315 no 204 0.038284846879617 88 4011080 SGTC_3175 9106517 49.47 µM 1.7674544591566 0.0336877179075443 no 205 0.0385760747117919 63 41468073 SGTC_1410 3909-8106 77.9 µM 1.76543735463356 0.0338460899307162 no 206 0.0387451450131707 71 1039210 SGTC_296 1222-0039 74.9 µM 1.76361918184938 0.0339893672950232 no 207 0.0388980580027749 60 5984176 SGTC_2689 tacrolimus 100 µM 1.7592377001554 0.0343366911066782 no 208 0.0392685716596591 74 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1654 st012436 41.8 µM 1.75141318079262 0.0349642007731838 no 209 0.0399373820951784 40 4323132 SGTC_2079 5212404 121 µM 1.75089435277699 0.0350061402728687 no 210 0.0399820548669922 61 758462 SGTC_2255 7941087 197.44 µM 1.74589626445445 0.035412279438613 no 211 0.0404144895586236 70 935561 SGTC_2073 5212005 126 µM 1.74392516576497 0.0355735075446957 no 212 0.0405860698747555 66 691789 SGTC_2015 5119600 184 µM 1.74277445798172 0.0356679087710743 no 213 0.040686509800176 88 2828786 SGTC_631 k072-0230 41.5 µM 1.73363462182762 0.0364250323917598 no 214 0.0414914666950382 74 5773147 SGTC_405 ebelactone b 50 µM 1.73359354489696 0.0364284645713421 no 215 0.0414951133096662 41 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2215 7188065 200 µM 1.72452786095881 0.0371924469499471 no 216 0.0423062968901078 46 940217 SGTC_1102 cgs 12066b 26.1 µM 1.72426146719319 0.037215092970664 no 217 0.0423303260606113 65 6438352 A 5-HT1B full agonist. SGTC_439 amiodarone 34.4 µM 1.71618553629834 0.0379069897425577 no 218 0.0430640447993327 73 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1836 st055642 81 µM 1.71573953987846 0.0379455038236762 no 219 0.0431048622087446 85 8571 SGTC_3223 9129970 49.47 µM 1.71562195961619 0.0379556627994645 no 220 0.0431156283100937 72 17248386 SGTC_3190 9110366 49.47 µM 1.71378977896481 0.0381142507385379 no 221 0.0432836706176329 64 17123768 SGTC_1994 st072947 40.9 µM 1.7115399968366 0.0383097238114379 no 222 0.0434907371230733 68 5286565 YDL195W SEC31 SGTC_911 3456-4043 236 µM 1.70717850161695 0.0386910018733918 no 223 0.0438944398111744 78 914281 SGTC_2268 7933382 153.85 µM 1.70706597565428 0.0387008795557295 no 224 0.0439048951451173 76 935025 YOR257W CDC31 SGTC_1928 4'-methoxychalcone 40.3 µM 1.69776051335536 0.0395248625121286 no 225 0.0447764856757161 81 641818 SGTC_1983 st071813 46.9 µM 1.69759927565793 0.0395392646346441 no 226 0.0447917098201092 69 11838595 SGTC_863 0466-0191 129 µM 1.69522080080265 0.0397522117985237 no 227 0.0450167711955311 96 765160 YPR165W RHO1 SGTC_1834 st055981 52.8 µM 1.69494863529815 0.0397766383821574 no 228 0.0450425825818711 79 471719 YDL150W RPC53 SGTC_1313 1220-0047 237 µM 1.69079197429165 0.0401512131272048 no 229 0.0454382702819197 91 3528706 SGTC_1927 st060202 13.8 µM 1.68476687994228 0.0406992426687898 no 230 0.0460167786337147 74 688887 SGTC_2219 9098279 200 µM 1.68160561880779 0.0409892031489665 no 231 0.0463226701677621 29 902349 SGTC_3103 9120822 49.47 µM 1.68048846541182 0.0410920716629197 no 232 0.0464311583341004 103 17141819 SGTC_2933 9026794 32.47 µM 1.6779375343383 0.0413277486182438 no 233 0.0466796470682516 69 17586027 SGTC_3208 9114115 49.47 µM 1.67711565070927 0.0414039142425859 no 234 0.0467599344603022 114 650895 SGTC_1295 1013-0063 9.78 µM 1.67635519503308 0.0414744884999379 no 235 0.0468343197719921 75 6826038 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.67232754996218 0.04184990194146 no 236 0.0472298749548951 92 5393153 SGTC_329 k048-0121 21.3 µM 1.67219661251275 0.0418621525407652 no 237 0.0472427791306096 73 6832902 SGTC_2647 atorvastatin 60.16 µM 1.66950971819872 0.042114182021741 no 238 0.047508203020152 57 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2474 5321570 43.32 µM 1.66871830384806 0.0421886500089592 no 239 0.0475866099555018 72 2841384 SGTC_1385 3091-4834 14.1 µM 1.6670163959707 0.0423491516750049 no 240 0.047755572340293 65 4072814 SGTC_168 3970-0862 530.542 µM 1.66662931201525 0.0423857252279449 no 241 0.0477940683223328 140 3135186 SGTC_590 k048-0076 22.4 µM 1.66513071879791 0.0425275605183925 no 242 0.0479433396456647 82 6832814 SGTC_2205 7238770 200 µM 1.65743218760517 0.0432622543136974 no 243 0.0487160641714245 63 279867 SGTC_2040 5100729 123 µM 1.65303389163628 0.0436865762831301 no 244 0.0491619830846195 80 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1825 st052143 62.6 µM 1.6529448007133 0.0436952058319922 no 245 0.0491710490926005 77 674173 SGTC_748 act1.228 77.9 µM 1.65261382448614 0.0437272769870757 no 246 0.0492047413580173 76 4421505 YNR035C ARC35 SGTC_2827 7993847 71.43 µM 1.65125936187423 0.0438587205543913 no 247 0.0493428132358308 67 2985692 SGTC_899 1083-0020 478 µM 1.64957398602037 0.044022722358156 no 248 0.0495150496352817 84 767123 SGTC_290 2043-6722 48.1 µM 1.64871485609035 0.0441065133031584 no 249 0.0496030325836174 73 773758 YLR208W SEC13 SGTC_2845 9003024 42.97 µM 1.64403777116059 0.0445649273619155 no 250 0.0500842002843205 82 2990173 SGTC_785 1270-0111 65.3 µM 1.63969106311582 0.0449943938203489 no 251 0.0505347090280827 78 6741994 SGTC_958 1222-0007 33 µM 1.63915313785366 0.0450477731483483 no 252 0.0505906853460555 89 7312461 SGTC_2177 5811945 192 µM 1.63896844215624 0.0450661125966886 no 253 0.0506099161030577 75 5343475 SGTC_2127 5253358 187.912 µM 1.63003420299432 0.0459604410849863 no 254 0.051547134195202 79 20612 SGTC_130 0136-0219 337.655 µM 1.62991762736925 0.0459722040119285 no 255 0.0515594537883063 91 234244 SGTC_264 promethazine 12.5 mM 1.62979937204222 0.04598413889837 no 256 0.051571953282494 120 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2061 5245884 80.95 µM 1.62894578440713 0.0460703608454087 no 257 0.0516622482955028 77 573863 SGTC_1112 tnp00069 1.16933 µM 1.62501802473892 0.0464687836911703 no 258 0.0520793591188748 71 145826 SGTC_2902 5787006 60.46 µM 1.62391269281241 0.0465814032901052 no 259 0.0521972216145524 83 591003 SGTC_655 k060-0012 42 µM 1.62221894375538 0.0467544001527625 no 260 0.0523782384544064 94 5994525 SGTC_1724 st037281 8.293 µM 1.62146208357126 0.046831871100889 no 261 0.05245928768206 91 574124 YDL195W SEC31 SGTC_1321 1326-2144 215 µM 1.61473207717575 0.0475252805189137 no 262 0.0531843639256631 88 3513030 SGTC_2783 7738165 71.43 µM 1.61132427889154 0.047879518150155 no 263 0.0535545308266308 77 17201110 SGTC_2207 7258803 200 µM 1.61006233153017 0.0480112315536836 no 264 0.0536921247059216 69 3666799 SGTC_1086 cerivastatin 2.18 µM 1.60432251041298 0.0486139779913276 no 265 0.05432149087082 73 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1685 st024049 53.0905 µM 1.59889487484893 0.0491894918126739 no 266 0.0549219815168936 77 1941139 SGTC_2055 5235184 200 µM 1.5967115327764 0.0494225294254372 no 267 0.0551650118538125 82 2836034 SGTC_1413 3910-0535 34.4 µM 1.59558120805632 0.0495435196786155 no 268 0.0552911629247717 93 2876951 SGTC_2118 5526350 200 µM 1.59485277888044 0.0496216161048659 no 269 0.0553725806720368 92 743594 SGTC_1955 wogonin 32.4 µM 1.59256155985167 0.0498679031329609 no 270 0.0556292913835289 64 5281703 A flavanone. SGTC_2852 9023854 51.95 µM 1.59179693556854 0.0499503105407103 no 271 0.0557151694712403 105 19798528 SGTC_2710 st078562 53.7235 µM 1.58707623922203 0.0504614914205844 no 272 0.0562476893085724 93 17250908 SGTC_1424 4048-1941 275 µM 1.58526076369708 0.0506591865273923 no 273 0.0564535498851818 81 X1424 SGTC_1523 st012844 44.7 µM 1.57910854762562 0.0513337190279327 no 274 0.0571555807205087 71 4274103 SGTC_2781 5567276 71.43 µM 1.57649685961677 0.0516222176442582 no 275 0.0574556709643668 100 2853274 SGTC_1511 0906-3109 28.5 µM 1.57623567560232 0.0516511399496927 no 276 0.0574857497871246 91 2882180 SGTC_2374 9071832 200 µM 1.57616360556408 0.0516591229186054 no 277 0.0574940517934642 75 17381698 SGTC_1395 3486-0190 4.35 µM 1.57606193042247 0.0516703868186437 no 278 0.0575057657217236 87 6748079 SGTC_2130 NSC 7 2.4545 µM 1.57574596611899 0.0517054028247811 no 279 0.0575421797498831 83 21448 SGTC_540 1187-0821 17.3 µM 1.57018150844827 0.0523251674874801 no 280 0.0581864451251884 99 847520 SGTC_2311 7694451 200 µM 1.55820811195975 0.0536787519779572 no 281 0.0595919613228141 125 2163142 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.55585237854667 0.0539483030415923 no 282 0.0598715997926862 89 803109 SGTC_2182 6325192 200 µM 1.54579361663197 0.0551113367593564 no 283 0.0610772095868616 81 736248 SGTC_106 0092-0003 11.579 µM 1.54446748491454 0.0552661362228109 no 284 0.0612375611796394 82 1072148 SGTC_1157 4092-0394 27.6 µM 1.54434827211467 0.0552800687488853 no 285 0.0612519921086373 79 3659885 SGTC_3234 9132280 49.47 µM 1.53718257005671 0.0561226384073748 no 286 0.0621243036957403 90 17612295 SGTC_644 1498-1197 63.3 µM 1.53178728697219 0.0567636933822219 no 287 0.0627874671252678 97 6741615 SGTC_1901 st060216 58.6 µM 1.52804673645627 0.0572115123238913 no 288 0.0632504672360494 86 688792 SGTC_337 1315-0038 354 µM 1.52758837717564 0.0572665778335952 no 289 0.0633073846629767 70 1626437 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.5274367088285 0.0572848078628125 no 290 0.0633262270770001 61 6708630 An antioxidant. SGTC_3304 9125678 46.087 µM 1.52617427648924 0.0574367252753629 no 291 0.0634832339554281 115 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3284 9108171 64.8615 µM 1.52478771235795 0.0576039453831508 no 292 0.0636560278561508 91 8687505 SGTC_2081 5214970 32.255 µM 1.52445040990576 0.057644682019209 no 293 0.0636981178419081 76 2063512 SGTC_1989 st071868 50.2 µM 1.52287441424344 0.0578353182042631 no 294 0.0638950640327824 100 16414057 SGTC_788 1182-0090 188 µM 1.51843693925171 0.058374748771201 no 295 0.0644521427191177 104 5715185 SGTC_1378 2093-0007 380 nM 1.51708492022658 0.0585398866237602 no 296 0.0646226225122771 104 3618014 SGTC_832 4083-0019 164 µM 1.51328333963596 0.0590061840057028 no 297 0.065103851381923 131 1990758 SGTC_2986 9022445 71.43 µM 1.51085197464275 0.059305936826457 no 298 0.0654130845519793 100 6459286 SGTC_2976 9009005 19.48 µM 1.51083557737024 0.0593079624232516 no 299 0.0654151738999035 63 2993148 SGTC_2745 rifampicin 24.3 µM 1.50990072867678 0.0594235363942566 no 300 0.0655343783665315 47 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2473 5854593 8.94 µM 1.50233244325383 0.0603657038753573 no 301 0.0665056369441353 104 2872951 SGTC_2084 5306078 60.6385 µM 1.50200460637026 0.0604067785874231 no 302 0.0665479595987356 102 679340 SGTC_784 4579-0127 173 µM 1.49134351582782 0.0617544647278962 no 303 0.0679356647777705 101 1948547 SGTC_2737 bleomycin 30.5 nM 1.49040554792738 0.0618741493722399 no 304 0.0680588173244513 100 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1783 st039459 87.517 µM 1.48942796562486 0.0619990814062155 no 305 0.0681873544824164 102 729761 SGTC_3245 9134821 49.47 µM 1.48656770753124 0.0623657443181276 no 306 0.0685645109905 112 17014901 SGTC_685 1278-0033 54.9 µM 1.48385921533634 0.0627145087116474 no 307 0.0689231368588957 106 3590572 SGTC_1073 triclabendazole 3.09 µM 1.48124512103283 0.0630525574159992 no 308 0.0692706332612631 94 50248 An antihelmetic and likely tubulin inhibitor. SGTC_724 3910-0327 137 µM 1.47645102892166 0.0636762046130095 no 309 0.06991142622658 117 2885483 SGTC_3173 9105693 49.47 µM 1.47384944861471 0.0640166384352421 no 310 0.0702610655206611 95 17096658 SGTC_55 0767-0285 6.563 µM 1.47336645013631 0.0640799974229069 no 311 0.0703261258372586 92 3116166 SGTC_2853 9015042 58.44 µM 1.4698092237827 0.0645481316313641 no 312 0.0708067151599422 80 6457456 SGTC_1923 st058458 19.1 µM 1.46864726896281 0.0647016202107643 no 313 0.0709642434036509 114 3534982 SGTC_1199 1638-0010 4.46 µM 1.45642079819653 0.0663339076602915 no 314 0.0726381647703151 109 3111136 SGTC_1907 st060210 83.7 µM 1.45453028991661 0.0665891206958807 no 315 0.0728996710001663 113 688793 SGTC_72 0744-0168 198.391 µM 1.45295492023588 0.0668023709324849 no 316 0.0731181353937131 99 677577 SGTC_1204 4049-0315 18.3 µM 1.44763630563072 0.0675262310559773 no 317 0.0738593959716984 93 588402 SGTC_1402 3909-7673 35.9 µM 1.44665208225617 0.0676608453784351 no 318 0.0739971956783637 88 5328014 SGTC_1483 3453-0561 55.9 µM 1.4408163108085 0.0684632792472487 no 319 0.0748182920918612 117 4546991 SGTC_1874 staurosporine 7.6 µM 1.43594206766055 0.0691391106818318 no 320 0.075509413355626 104 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1127 asiatic acid 681.4 nM 1.43439071323938 0.069355286602887 no 321 0.0757303981592757 105 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1183 1254-0324 198 µM 1.43151598056994 0.0697572465212419 no 322 0.0761411951475539 88 5799357 SGTC_3341 9147222 25.867 µM 1.42922264596866 0.0700791963029733 no 323 0.0764701253918852 111 1939759 SGTC_1446 4239-0190 62 µM 1.42455949772455 0.0707373561281541 no 324 0.0771422874221252 106 1340085 SGTC_2391 6285546 200 µM 1.42294510379141 0.0709663162398521 no 325 0.0773760348496798 89 846083 SGTC_1716 st033144 30.6155 µM 1.41918129816921 0.071502325125243 no 326 0.0779230834328716 107 674617 SGTC_1851 st056236 18.9 µM 1.41891645770585 0.0715401581067611 no 327 0.0779616867894398 113 5393171 SGTC_2626 ethyl orsellinate 100 µM 1.41845303371207 0.0716063960886451 no 328 0.0780292707483285 130 75653 A natural product. SGTC_1727 st034309 9.9045 µM 1.41697694009685 0.0718176903132616 no 329 0.0782448348012105 133 870305 SGTC_519 k048-0011 62.8 µM 1.4091866015423 0.0729407615423545 no 330 0.0793899992624813 101 6836379 SGTC_1469 k284-2957 126 µM 1.40824895992646 0.073076835298976 no 331 0.0795286816606249 112 23884841 SGTC_2298 7976326 193.81 µM 1.40528994009307 0.0735075323815267 no 332 0.0799675392823283 66 2235818 SGTC_1013 4112-3890 241 µM 1.40327385215057 0.0738020919944036 no 333 0.0802675961633344 119 705171 SGTC_303 1348-1668 34.2 µM 1.3979941560664 0.0745777539785719 no 334 0.0810574110460742 110 5380509 SGTC_3082 9117008 49.47 µM 1.39695830915955 0.0747306620603833 no 335 0.0812130542506585 109 41448529 SGTC_2835 9006588 71.43 µM 1.39586756016875 0.0748919330562238 no 336 0.081377190497872 87 2345538 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.3928031288223 0.0753464405196813 no 337 0.0818396660103683 125 616764 SGTC_2432 5630864 12.22 µM 1.38795677633087 0.0760695249470518 no 338 0.0825751036948803 110 5714970 SGTC_3011 9081274 71.4286 µM 1.38719514248225 0.0761836408234215 no 339 0.08269113312817 108 6625322 SGTC_621 3584-0052 32.1 µM 1.38707711252011 0.0762013369502482 no 340 0.0827091251181528 117 2273927 SGTC_233 rapamycin 362 pM 1.38565398723935 0.0764149511939664 no 341 0.0829262922955664 100 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1303 1160-0052 261 µM 1.3841655464543 0.0766388565647142 no 342 0.0831538851754769 95 3562476 SGTC_3071 9117417 49.47 µM 1.38412009007279 0.0766457023878046 no 343 0.0831608431541684 107 45595590 YGL055W OLE1 SGTC_1496 4469-0713 57.4 µM 1.38243933789961 0.0768991537017783 no 344 0.0834184222612988 112 746691 SGTC_1762 st045503 25.4615 µM 1.37727341292766 0.0776821452548954 no 345 0.0842138659943561 96 4645554 SGTC_3112 9123419 49.47 µM 1.37518769104874 0.07799998459277 no 346 0.0845366316907853 118 17015854 SGTC_213 1246-0773 967 nM 1.37364868912536 0.078235142201567 no 347 0.084775386770997 91 6251622 SGTC_3282 9108498 15.4605 µM 1.37053900132941 0.0787119389927867 no 348 0.0852593547160796 125 16459645 SGTC_134 0269-0018 6.916 µM 1.36831242937994 0.0790546814193723 no 349 0.0856071509216189 121 4378915 SGTC_722 3534-0461 190 µM 1.36682387879585 0.0792844477841211 no 350 0.08584025810965 91 658262 SGTC_3072 9116419 49.47 µM 1.3605342271386 0.08026087535009 no 351 0.0868304646735078 120 17170162 SGTC_3323 9138564 53.9225 µM 1.3581811557552 0.0806285011987636 no 352 0.0872031042692204 116 43912313 YNL103W MET4 SGTC_398 bronopol 33.3 µM 1.35586497819387 0.0809916036580251 no 353 0.0875710661528601 123 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1106 tegaserod maleate 11.7 µM 1.35512270624121 0.0811082288898049 no 354 0.0876892327414902 128 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_446 go6976 132 µM 1.35441145020791 0.0812200997788333 no 355 0.0878025732950013 106 3501 A protein kinase C inhibitor. SGTC_964 1287-0107 19.4 µM 1.3541203964305 0.0812659121274944 no 356 0.0878489849877504 120 51516812 YPR165W RHO1 SGTC_506 n9-isopropylolomoucine 153 µM 1.35130733806821 0.0817096974130323 no 357 0.0882985011874808 86 6610355 SGTC_1879 gemcitabine 100 µM 1.35050324086203 0.0818368861244898 no 358 0.0884273074073672 116 60750 A nucleoside analog which inhibits DNA replication. SGTC_542 3381-0244 89.3 µM 1.34953985767134 0.0819894664352197 no 359 0.0885818135189931 115 1112843 SGTC_500 h-89 112 µM 1.343664794148 0.0829245996833207 no 360 0.0895284033510614 126 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2598 perillyl alcohol 100 µM 1.34167646691185 0.0832428919684594 no 361 0.0898504602927222 104 10819 An apoptosis inducer. SGTC_2278 7948257 134.34 µM 1.34077909745693 0.0833868437227796 no 362 0.0899960923328543 102 1247028 SGTC_1220 1838-0075 193 µM 1.34046230503988 0.0834377067230225 no 363 0.0900475457183305 106 5529645 SGTC_2096 5468907 200 µM 1.33827018288082 0.0837903047380245 no 364 0.090404188986736 110 759785 SGTC_2877 9040724 71.43 µM 1.33155211414624 0.0848778619842527 no 365 0.0915037046455415 106 6463895 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.32941698318724 0.0852257152879231 no 366 0.0918552189158919 130 688788 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.31932266796541 0.0868847435741167 no 367 0.0935306313535433 106 6312947 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.31825946243376 0.0870608791844233 no 368 0.0937084030770436 108 6857784 SGTC_3150 9097574 49.47 µM 1.31595131907876 0.0874441747187568 no 369 0.0940951912021012 110 17217476 SGTC_2276 7947513 42.08 µM 1.31385915454283 0.0877926913023808 no 370 0.0944468031620465 115 2105100 SGTC_3329 9141233 27.5565 µM 1.31212009369285 0.0880831749489658 no 371 0.0947398086053311 123 4909101 YNL103W MET4 SGTC_2540 epiandrosterone 100 µM 1.31209088201871 0.0880880604265459 no 372 0.0947447360448701 126 441302 A steroid. SGTC_146 3448-8650 53.125 µM 1.3103775859563 0.0883749524500236 no 373 0.0950340661483015 146 2891488 YIL048W NEO1 SGTC_2436 5633522 8.09 µM 1.30940158840755 0.0885386945663065 no 374 0.0951991768560206 125 5724242 SGTC_1408 3909-7976 48.8 µM 1.30331412869533 0.0895650855565761 no 375 0.0962337697402273 118 24152374 SGTC_2354 9060492 162 µM 1.30173835793522 0.0898322082399234 no 376 0.0965029211370248 137 6471895 SGTC_932 2857-0803 154 µM 1.30172140586877 0.089835085148957 no 377 0.0965058196587732 128 674898 SGTC_2094 5332512 191.667 µM 1.29908168641192 0.0902839039076188 no 378 0.0969579486423303 128 755774 SGTC_1025 k007-0731 70 µM 1.29812224037029 0.090447445872112 no 379 0.0971226664974729 114 6256118 SGTC_1629 st005085 44.9 µM 1.29633820084416 0.0907521281523513 no 380 0.09742949651442 143 24207091 SGTC_1169 aniline yellow 25.8 µM 1.29628483706273 0.0907612534565863 no 381 0.0974386852832164 125 6051 A DNA damaging agent. SGTC_2105 5350118 200 µM 1.29544699956205 0.0909046144839727 no 382 0.0975830368003187 138 2133313 SGTC_1922 5578187 25 µM 1.29544403065117 0.0909051227880788 no 383 0.0975835485944122 130 1350412 SGTC_2861 9024595 19.48 µM 1.29435106932008 0.0910923908542228 no 384 0.0977720919110283 79 16482810 SGTC_1389 3405-0187 19 µM 1.29173016242177 0.0915426226485261 no 385 0.098225304054265 118 799890 SGTC_539 4859-0462 2.54 µM 1.29152432093893 0.0915780527958592 no 386 0.0982609636178475 140 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1216 1165-0504 9.65 µM 1.28534712325743 0.0926460267075245 no 387 0.0993355049795656 138 6304004 SGTC_489 paxilline 115 µM 1.28254676208628 0.0931332038762282 no 388 0.099825456025787 115 105008 A toxic potassium channel blocker. SGTC_1236 0330-0013 258 µM 1.28209191263412 0.0932125121689016 no 389 0.0999052028182297 106 4617066 SGTC_2455 5377712 9.75 µM 1.28071570234007 0.0934527743487726 no 390 0.100146771177773 124 2243908 SGTC_1406 3909-7906 11.9 µM 1.2793317022091 0.0936948575033796 no 391 0.100390136673113 122 X1406 SGTC_379 3970-0972 5.9 µM 1.27888904956931 0.0937723819748293 no 392 0.100468064659499 121 2898042 YBL034C STU1 SGTC_2450 5739737 12.93 µM 1.27677752850679 0.0941428373560892 no 393 0.10084040058657 114 2262825 SGTC_1370 2001-0092 44.6 µM 1.27537210230263 0.0943900098501959 no 394 0.101088784089661 143 790957 SGTC_466 geldanamycin 89.2 µM 1.2743850027919 0.0945638970401025 no 395 0.101263502341336 86 5288382 HSP90 inhibitor. SGTC_65 0798-0905 34.986 µM 1.273816526753 0.0946641467315461 no 396 0.101364223335489 138 3602145 SGTC_1570 verbenone 133 µM 1.27203571478331 0.09497869663089 no 397 0.101680214987744 130 29025 A natural terpanoid with antifungal properties. SGTC_1623 st003709 20.3 µM 1.26749126311854 0.0957848843265435 no 398 0.102489842830147 125 16192618 SGTC_497 capsazepine 133 µM 1.26611177709307 0.0960305988801876 no 399 0.10273653338394 112 2733484 A calcium channel blocker. SGTC_593 1203-0218 61.7 µM 1.26396442259085 0.096414008233011 no 400 0.103121398445926 141 3666956 SGTC_416 estradiol valerate 100 µM 1.26278882000812 0.0966243875311858 no 401 0.103332541817526 138 13791 A steroid. SGTC_729 4092-0585 94.1 µM 1.26133239528889 0.0968854885953442 no 402 0.103594557122894 120 2169061 SGTC_2523 spermine 47.74 µM 1.26086485503003 0.0969694167855066 no 403 0.103678771197254 105 1103 A DNA binding polyamine. SGTC_1732 st034308 51.822 µM 1.25886341654054 0.0973292984722773 no 404 0.104039834822583 139 830119 SGTC_2167 5876490 200 µM 1.25874414201057 0.097350776302747 no 405 0.104061380943585 125 686534 SGTC_443 clozapine 122 µM 1.25575624646417 0.0978899433598097 no 406 0.104602179710862 118 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3281 9140613 49.47 µM 1.25009014508076 0.0989183983805456 no 407 0.105633309677934 120 16013766 SGTC_2431 5490079 200 µM 1.24877853947301 0.0991575908662658 no 408 0.105873042662494 159 5722345 SGTC_878 0828-0289 13.7 µM 1.24360032187306 0.100106054097758 no 409 0.106823348834909 145 745350 YLR208W SEC13 SGTC_323 4013-0906 34.3 µM 1.24020906298071 0.100730789816816 no 410 0.107449038546764 123 2910086 SGTC_2887 9044784 58.44 µM 1.23975463998099 0.100814718915248 no 411 0.10753308019238 155 6465546 SGTC_1893 st059353 36.1 µM 1.2392951354343 0.100899638383219 no 412 0.10761810978416 149 3112488 SGTC_895 0964-0006 13.7 µM 1.23819726792384 0.101102742663903 no 413 0.1078214621706 172 6738897 SGTC_1286 0929-0070 131 µM 1.23738042340237 0.10125405121075 no 414 0.107972941570422 141 1420408 SGTC_52 0329-0193 875 nM 1.23577770289875 0.101551411172365 no 415 0.108270602617373 137 3739292 SGTC_1868 st057644 42.7 µM 1.23481182894729 0.101730920962957 no 416 0.108450271973005 126 688665 SGTC_1414 3917-0015 5.4 µM 1.23007416574143 0.102614772184625 no 417 0.109334666605462 128 6618702 SGTC_805 3852-0218 479 µM 1.22833947205707 0.102939786065672 no 418 0.10965977965125 134 6615355 SGTC_1754 st042065 16.137 µM 1.22637574670787 0.103308613284379 no 419 0.110028654282675 155 1126236 YIL048W NEO1 SGTC_674 0498-0004 451 µM 1.22526929524571 0.103516849291229 no 420 0.110236886598283 161 4231473 SGTC_2435 5706476 10.6 µM 1.22341855513805 0.103865842282418 no 421 0.110585824303331 127 5725375 SGTC_2683 piperine 63.03 µM 1.22161702820346 0.104206374056475 no 422 0.110926243074448 153 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2973 9094665 17.96 µM 1.22031445296939 0.104453095622508 no 423 0.111172846471179 167 25237061 YIL048W NEO1 SGTC_2705 st078069 42.8 µM 1.21995622212774 0.104521022490413 no 424 0.111240735465586 129 1530061 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.21233336134265 0.105974044320819 no 425 0.112692399168004 155 165506 SGTC_1503 4585-0012 61.3 µM 1.21023575864627 0.10637642508361 no 426 0.113094220205152 127 2922052 SGTC_3016 9080866 49.47 µM 1.2101969530545 0.106383879496321 no 427 0.113101663502979 139 17066299 SGTC_3305 9127027 53.8275 µM 1.20225581405967 0.107917289633559 no 428 0.114632215317233 157 41905295 SGTC_2769 toremifene 3.73 µM 1.19986098337917 0.108382833055645 no 429 0.115096667562582 152 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_858 0438-0351 2.77 µM 1.19724984597871 0.108892070303843 no 430 0.115604593294962 146 2799119 SGTC_2277 7947813 106.88 µM 1.193180569586 0.109689106604556 no 431 0.116399331324815 138 1246798 SGTC_2994 9053520 71.4286 µM 1.19256077664977 0.109810870082093 no 432 0.116520717464394 114 4647384 SGTC_2764 methyldopa 94.69 µM 1.19092324556824 0.110133043379058 no 433 0.116841859001543 133 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_169 k015-0017 16.025 µM 1.19086152976487 0.110145198795807 no 434 0.116853974544351 150 1840002 SGTC_51 1013-0126 23.419 µM 1.19022779727797 0.110270073114736 no 435 0.11697843525591 117 1627850 SGTC_3002 9075603 71.4286 µM 1.1886982909801 0.110571874043787 no 436 0.117279206690189 158 20105405 SGTC_1594 piperine 70.1 µM 1.18689375276075 0.110928704827511 no 437 0.117634765915163 135 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3130 9127414 49.47 µM 1.18501091363366 0.111301897456134 no 438 0.118006565942633 140 1494646 SGTC_975 1335-0046 28.5 µM 1.18460770252024 0.111381933588781 no 439 0.11808629508747 144 16486740 SGTC_272 doxorubicin 8.13 µM 1.18397573919542 0.11150745917839 no 440 0.118211333300592 158 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3169 9102970 49.47 µM 1.17755961039838 0.112787615812379 no 441 0.119486109886818 140 17027839 SGTC_1435 4092-0789 56.7 µM 1.17744381395661 0.112810815711363 no 442 0.119509205441551 163 2248285 SGTC_2148 5546263 113.568 µM 1.17665374888457 0.112969196735019 no 443 0.119666867657637 142 792097 SGTC_1440 4100-1550 40 µM 1.17389734439031 0.11352300413765 no 444 0.12021807314348 153 742806 SGTC_155 k072-0202 43.6 µM 1.17183560572983 0.113938505287526 no 445 0.120631532229865 164 5857737 SGTC_3039 9090270 49.47 µM 1.17093207388364 0.114120934676163 no 446 0.120813040784646 123 17173750 SGTC_2248 tofa 1.1 µM 1.16614889616856 0.115090157875645 no 447 0.1217771251254 161 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1343 1487-0095 224 µM 1.16541068997395 0.115240261650513 no 448 0.12192639611766 164 4560101 YGL055W OLE1 SGTC_702 1488-0190 94 µM 1.16440296943265 0.115445391929789 no 449 0.122130372393133 112 949357 SGTC_2447 5741742 33.78 µM 1.16408118857757 0.11551094784285 no 450 0.122195555634303 151 1776504 SGTC_1425 4048-4433 7.33 µM 1.16376913588138 0.115574547111918 no 451 0.122258791564046 185 23734946 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.16304650565296 0.115721921437044 no 452 0.122405317177123 164 688801 SGTC_2387 9077560 195.08 µM 1.16244174617727 0.115845359572841 no 453 0.122528037177308 141 5303272 SGTC_331 k048-0133 24.5 µM 1.16200074533885 0.115935431679741 no 454 0.122617581088625 146 6813582 SGTC_2875 9039966 71.43 µM 1.16164342609043 0.116008448717819 no 455 0.122690167361471 129 6463691 SGTC_3272 9137413 49.47 µM 1.16085073138374 0.116170549859863 no 456 0.122851303928722 158 17614870 SGTC_1004 4084-0029 199 µM 1.1585473197665 0.116642495245392 no 457 0.123320376382801 127 716894 YLR208W SEC13 SGTC_2225 6654152 15.4 µM 1.15569846969671 0.117228073839331 no 458 0.1239022571691 155 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_18 0111-0177 500 nM 1.15347399715672 0.117686757788255 no 459 0.124357942248726 158 721752 SGTC_629 3448-6466 76.7 µM 1.15290635596562 0.117804007974929 no 460 0.124474411487453 164 573744 SGTC_2252 omeprazole 400 µM 1.15177648474761 0.118037636598997 no 461 0.124706466635042 124 4594 A proton pump inhibitor. SGTC_1026 k007-1105 30.6 µM 1.15168438125426 0.118056695694771 no 462 0.124725396348806 170 7066794 SGTC_100 0086-0128 49.5915 µM 1.1514550473771 0.118104161509683 no 463 0.124772539275684 156 93297 SGTC_566 0958-0068 16.5 µM 1.15077495905065 0.118245000473557 no 464 0.124912414571197 153 6815365 SGTC_2765 myclobutanil 7.74 µM 1.14822883334221 0.118773330055754 no 465 0.125437054617679 169 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2999 9069765 71.4286 µM 1.14766053978122 0.118891480150676 no 466 0.125554363571723 133 2097066 SGTC_3117 9124945 49.47 µM 1.14389948354014 0.119675508740874 no 467 0.126332662631347 119 17592065 SGTC_3231 9132313 49.47 µM 1.14374292621984 0.119708223495559 no 468 0.126365132748676 161 4905967 SGTC_1115 galangin 695.678 nM 1.14284686051178 0.119895589810654 no 469 0.126551089404926 171 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1230 0170-0365 3.77 µM 1.14013387504643 0.120464132218211 no 470 0.127115265475749 165 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2839 9003951 25.97 µM 1.13696834975029 0.121129907350799 no 471 0.127775758500854 132 2990634 SGTC_2047 4141938 200 µM 1.13621454809492 0.12128882818811 no 472 0.12793339168108 162 3807862 SGTC_949 1165-0505 146 µM 1.13215057562212 0.122148144480706 no 473 0.128785567476212 145 6244267 SGTC_384 k007-0144 5.16 µM 1.13137145506951 0.122313374589639 no 474 0.128949390342894 169 6824886 SGTC_736 0958-0254 92.6 µM 1.12975361532195 0.122656975003687 no 475 0.129290029158207 159 6812352 SGTC_2245 6637752 200 µM 1.1287268678294 0.12287538882632 no 476 0.129506535757348 147 681890 SGTC_1268 0828-0275 2.46 µM 1.12807449496614 0.12301430579296 no 477 0.12964422973884 163 745337 SGTC_3220 9131269 49.47 µM 1.12799776952261 0.123030651022932 no 478 0.1296604305626 150 17722206 SGTC_609 0986-0026 86.3 µM 1.1256115986233 0.123539749836772 no 479 0.130164978249646 161 2848610 SGTC_2486 5283202 22.39 µM 1.12405943009909 0.12387170198605 no 480 0.130493907376044 142 1377751 SGTC_935 2996-0153 430 µM 1.12402760854036 0.12387851397979 no 481 0.130500656876919 162 23738523 SGTC_1676 st018489 23.4 µM 1.12276301478246 0.124149435963996 no 482 0.130769078557968 142 3696235 SGTC_3338 9144300 39.5675 µM 1.12239320835178 0.124228740227912 no 483 0.130847645448325 130 4901274 SGTC_3182 9108849 49.47 µM 1.12206501807883 0.124299149660691 no 484 0.130917398133516 152 17133045 SGTC_2709 st078560 56 µM 1.11513039209301 0.125793422309373 no 485 0.132397274692577 177 17250903 SGTC_2964 9083345 53.42 µM 1.11473648386831 0.125878676110333 no 486 0.132481680915715 165 17741579 SGTC_2072 5231554 129 µM 1.11337054135445 0.126174619997827 no 487 0.132774660763202 170 789545 SGTC_900 1112-0045 141 µM 1.10799273421135 0.127344482723598 no 488 0.133932476905657 157 56211 YIL048W NEO1 SGTC_1380 2291-0730 164 µM 1.10713237920529 0.12753233806965 no 489 0.134118349073374 160 2999191 SGTC_1755 st041960 45.185 µM 1.10297208917508 0.128443440282642 no 490 0.13501964304387 185 2257073 SGTC_1347 1493-0251 600 nM 1.10215833872868 0.128622178394832 no 491 0.135196420245057 154 3986378 SGTC_1979 st071809 45.3 µM 1.10165992450295 0.128731738943396 no 492 0.135304772887066 163 4976333 SGTC_2754 granisetron 64.02 µM 1.09161020761241 0.130954672768195 no 493 0.137502233769233 183 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1430 4049-0248 69.1 µM 1.08931564895178 0.131465911963718 no 494 0.138007357094832 169 22774488 SGTC_2492 derrusnin 100 µM 1.08823598602075 0.131706942344176 no 495 0.138245471024671 182 1715307 Part of coumarin class of compounds. SGTC_128 0906-2981 13.371 µM 1.08821940176758 0.131710647087973 no 496 0.138249130776543 178 6740226 SGTC_2365 9042475 200 µM 1.08452748319488 0.132537172288008 no 497 0.139065494080396 163 6464479 SGTC_1764 st044502 93.5 µM 1.08097569031328 0.133335693042094 no 498 0.139853963679362 154 8407 SGTC_2960 9079389 5.97 µM 1.0807663570986 0.13338285879482 no 499 0.139900528609848 135 16457355 SGTC_3212 9128307 49.47 µM 1.07956952919722 0.133652741541599 no 500 0.140166958199379 138 27243542 SGTC_3084 9116877 49.47 µM 1.07692240144599 0.134250997449411 no 501 0.140757467152301 135 27241325 SGTC_2162 5663267 200 µM 1.07537049052334 0.134602586214055 no 502 0.141104444049813 169 6456493 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.07433053109906 0.134838544611223 no 503 0.141337282912941 139 115019 SGTC_1789 tunicamycin 25 nM 1.07336212398539 0.135058523390936 no 504 0.141554335807167 176 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1547 harmine 94.2 µM 1.06901482253904 0.136049067268987 no 505 0.14253149520077 176 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1766 st045414 44.774 µM 1.06253492716568 0.137534738846389 no 506 0.143996455330252 160 253960 SGTC_473 2-arachidonoylglycerol 10 µM 1.0621602497434 0.137620980048611 no 507 0.144081471010818 177 5282280 An endocannabinoid. SGTC_2407 paclitaxel 400 µM 1.06198697728482 0.137660875435488 no 508 0.144120798610226 163 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3247 9135149 49.47 µM 1.06158290589973 0.137753942144108 no 509 0.144212538693298 195 8934436 YOR116C RPO31 SGTC_3244 9134489 49.47 µM 1.05980699404764 0.138163483443099 no 510 0.144616207147964 185 16584271 SGTC_2572 astragaloside iv 100 µM 1.05878051686123 0.138400576574469 no 511 0.144849874341595 165 45006101 An anti-inflammatory agent. SGTC_1933 st074711 15.9 µM 1.05845525191985 0.138475763277963 no 512 0.144923970642386 190 17250958 SGTC_2740 felodipine 17.08 µM 1.05746896084272 0.138703919793636 no 513 0.145148806605496 130 3333 L-type calcium channel blocker SGTC_1160 4092-0570 10.5 µM 1.05741277583634 0.138716924650272 no 514 0.145161621662432 170 4994975 SGTC_1293 1000-1278 195 µM 1.05719417941336 0.138767529950072 no 515 0.145211487859386 178 678847 SGTC_2302 7771753 200 µM 1.05478642777506 0.139325758946441 no 516 0.145761506623836 186 2203047 SGTC_2005 4024620 188 µM 1.05382681903122 0.139548666185345 no 517 0.145981106223341 171 236743 SGTC_246 cycloheximide 667 µM 1.05333016749461 0.139664128424729 no 518 0.146094848629185 178 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1344 1488-0097 29.1 µM 1.05312560818928 0.13971170353793 no 519 0.146141713806428 182 747966 SGTC_1948 st076329 66.6 µM 1.05232549541875 0.13989789454401 no 520 0.146325119133735 155 24208413 SGTC_2545 solidagenone 89.61 µM 1.04977500321327 0.140492534489864 no 521 0.146910785228582 127 6708572 An anti ulcer agent SGTC_2923 7992654 58.14 µM 1.04847541092683 0.140796189691699 no 522 0.147209812713591 169 2985126 SGTC_3235 9132602 49.47 µM 1.04829181964209 0.140839122437805 no 523 0.147252088706138 191 4912240 SGTC_2192 5915882 198.485 µM 1.04818718164952 0.14086359596247 no 524 0.147276187580798 164 2876149 SGTC_1008 4106-0037 6 µM 1.04700965650668 0.141139203361152 no 525 0.147547562254821 191 2905394 SGTC_1470 k295-0292 231 µM 1.04688344102938 0.141168766594156 no 526 0.147576669977192 189 5045612 SGTC_2665 lovastatin 100 µM 1.04668446640859 0.141215380601785 no 527 0.147622565172167 175 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.04536605081883 0.141524510939597 no 528 0.147926910510073 181 165521 SGTC_1336 1486-0901 104 µM 1.04440277399815 0.14175066118563 no 529 0.148149540371845 165 5006114 SGTC_152 4469-0003 551.229 µM 1.0432758548863 0.142015540531991 no 530 0.148410275212007 201 697280 SGTC_3058 9093861 49.47 µM 1.04296280243811 0.142089182109346 no 531 0.148482760472878 178 17217477 SGTC_228 caffeine 993.056 µM 1.04070432518308 0.14262122575543 no 532 0.149006397622455 133 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3200 9114385 49.47 µM 1.04017101684935 0.142747056895963 no 533 0.149130227161947 158 17018030 YLR208W SEC13 SGTC_2870 9038528 12.99 µM 1.03947328652806 0.14291179578551 no 534 0.149292337804982 172 6463316 SGTC_710 3448-4187 58 µM 1.03714133523304 0.143463317436094 no 535 0.14983499679429 174 3946412 SGTC_2970 9090938 41.86 µM 1.03651984412122 0.143610546314362 no 536 0.149979843248059 182 17217104 SGTC_1282 0886-0010 32.4 µM 1.03578400651933 0.14378499524394 no 537 0.150151460292218 190 2836211 YNL267W PIK1 SGTC_2313 7726885 200 µM 1.03491396282081 0.143991445523351 no 538 0.150354546619789 176 726423 SGTC_1944 st076371 56.9 µM 1.03422544886069 0.144154962747391 no 539 0.150515389795143 171 24208455 SGTC_3177 9107506 49.47 µM 1.03172630753919 0.144749542906501 no 540 0.151100174867609 159 8897194 SGTC_2919 7978188 46.38 µM 1.02751837009062 0.145754396125041 no 541 0.152088219943701 174 2980291 SGTC_3164 9100705 49.47 µM 1.02581254855014 0.146163077955973 no 542 0.152489975006441 138 17174235 SGTC_1975 st070967 30.8 µM 1.0248122340279 0.146403091631191 no 543 0.152725896352683 219 261391 SGTC_39 0986-0283 58.349 µM 1.02173399024188 0.14714333913436 no 544 0.153453409498238 170 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_452 diindolylmethane 8 µM 1.02147639761028 0.147205397871413 no 545 0.153514392933278 161 3071 Inhibits expression of several cancer promoting factors. SGTC_1877 wortmannin 25 µM 1.02065111458522 0.147404341660595 no 546 0.153709881571101 180 312145 A covalent inhibitor of PI 3-kinase. SGTC_131 0141-0277 33.849 µM 1.01889138004318 0.147829146939289 no 547 0.154127268225847 198 1547771 SGTC_679 0422-0091 41.4 µM 1.01816647568125 0.148004379207169 no 548 0.154299424151516 209 627384 YHR062C RPP1 SGTC_3315 9136395 68.55 µM 1.01794658213317 0.148057561891199 no 549 0.154351671308403 222 16876844 SGTC_2198 6589944 200 µM 1.01756277035765 0.148150419904781 no 550 0.154442893795981 151 5290268 SGTC_449 xestospongin c 11.1929 µM 1.01436418202387 0.148925790071682 no 551 0.15520450442062 175 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_842 0271-0008 11.1 µM 1.01059191491915 0.149843704215702 no 552 0.156105893537045 179 1221709 SGTC_2949 9072542 2.23 µM 1.0093743968346 0.150140769401994 no 553 0.156397556292911 180 16457352 SGTC_1731 st035964 63 µM 1.00485682645642 0.151246451123822 no 554 0.157482897998788 188 6739575 SGTC_768 0384-0033 77.3 µM 1.00049642120883 0.152318790753073 no 555 0.158535164346798 178 3965305 YMR134W ERG29 SGTC_558 k064-0027 21.3 µM 1.00045910383693 0.152327989815011 no 556 0.158544189744256 188 5088526 SGTC_387 norethindrone acetate 66.7 µM 1.00013275530819 0.152408453325553 no 557 0.158623133165593 174 541197 SGTC_740 k014-0057 261 µM 0.998893369762803 0.152714289443789 no 558 0.158923174214059 197 4012779 SGTC_2261 9010538 184.68 µM 0.998849826137515 0.152725041853559 no 559 0.158933722385776 200 6457250 SGTC_2412 st077135 33.4 µM 0.997560375853707 0.153043678821496 no 560 0.159246291629538 189 13258915 SGTC_2444 5485484 36.41 µM 0.993809654676711 0.153973025695328 no 561 0.160157772449188 204 6790631 SGTC_2472 5377652 49.4 µM 0.993290726418062 0.154101898240944 no 562 0.160284147757846 199 1610903 SGTC_2138 5575593 77.673 µM 0.992667990792702 0.154256644855498 no 563 0.160435889427709 177 762213 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.987417305919673 0.155565498214165 no 564 0.161719051937285 187 688662 SGTC_2856 9022925 19.48 µM 0.986162616299981 0.155879339578432 no 565 0.16202666040248 172 4944862 SGTC_1567 st069303 68.4 µM 0.984863505572846 0.156204731730542 no 566 0.1623455607684 198 5581319 SGTC_3149 9097855 49.47 µM 0.984825381573253 0.156214287516956 no 567 0.162354925457827 171 25236625 YMR079W SEC14 SGTC_3147 9097027 49.47 µM 0.984403025787028 0.156320176826957 no 568 0.162458695462399 218 25236841 SGTC_3298 9116858 71.43 µM 0.982289007515769 0.15685089519662 no 569 0.162978744222074 202 2506942 SGTC_2565 isoliquiritigenin 100 µM 0.981573450115273 0.157030802135582 no 570 0.163155016320868 191 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2269 7935389 174.42 µM 0.98047267280594 0.157307826774121 no 571 0.16342642621304 194 97605 SGTC_2137 5261020 140 µM 0.978571857021592 0.15778694723827 no 572 0.163895785225289 169 763655 SGTC_203 k066-0004 30.888 µM 0.977085245191865 0.15816233049786 no 573 0.164263475888255 208 6795412 SGTC_599 1935-0052 86.5 µM 0.977016797666662 0.158179628235181 no 574 0.164280418206222 165 9557311 SGTC_1861 st057647 17.4 µM 0.970325623475714 0.159876583253164 no 575 0.165942104505667 182 688668 SGTC_50 0929-0078 56.389 µM 0.968813658754438 0.160261677398262 no 576 0.16631908522379 174 1377751 SGTC_3007 9078383 71.4286 µM 0.968294403125771 0.160394070428071 no 577 0.166448679590129 192 6496995 SGTC_1739 st037196 92.5 µM 0.967759375897147 0.160530559429581 no 578 0.16658227836312 164 612214 SGTC_2795 7780010 54.55 µM 0.96729619744022 0.160648780588823 no 579 0.16669799204418 189 953673 SGTC_692 k241-0027 77.8 µM 0.964507834122532 0.161361680570763 no 580 0.167395691318773 188 3600480 SGTC_901 1112-0062 60.1 µM 0.96448026778823 0.161368738731013 no 581 0.16740259829768 181 1908457 SGTC_1908 st060353 56.5 µM 0.962604310305509 0.161849537135801 no 582 0.167873066818235 209 4227716 SGTC_2650 prasterone 100 µM 0.960666056069091 0.162347281265111 no 583 0.168360051812997 162 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2385 9074692 200 µM 0.959954172462522 0.162530343053892 no 584 0.168539139960988 174 17046906 SGTC_1993 st073995 70.8 µM 0.959208816307428 0.162722156230472 no 585 0.168726779974871 199 3098394 SGTC_2787 5284540 71.43 µM 0.959015287885071 0.162771983740265 no 586 0.1687755218193 206 736958 SGTC_59 0330-0160 1.33 µM 0.957936472651171 0.163049926704661 no 587 0.169047396755899 183 4293482 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.957430094855774 0.163180494799044 no 588 0.169175107239069 214 442882 SGTC_1745 st081495 74 µM 0.955945884826701 0.163563585513464 no 589 0.169549787658134 200 13842402 YBL026W LSM2 SGTC_380 3970-0968 6 µM 0.955711453612397 0.163624148117267 no 590 0.169609017142214 199 2891601 SGTC_2342 7990637 118.86 µM 0.955704236689635 0.163626012757108 no 591 0.169610840721802 208 2033102 YER133W GLC7 SGTC_1522 st012842 45.6 µM 0.954896485006683 0.16383479913756 no 592 0.169815023744744 205 3491067 YOR116C RPO31 SGTC_1338 1486-1223 76 µM 0.954862230533146 0.163843656999742 no 593 0.169823686053987 188 3444526 SGTC_54 0159-0055 9 µM 0.954360552441762 0.163973421514188 no 594 0.169950583426999 187 3319099 SGTC_227 fluconazole 33.516 µM 0.953523481051039 0.164190087577102 no 595 0.170162452422717 234 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1298 1079-1278 263 µM 0.952482739389008 0.164459730099678 no 596 0.170426107803124 194 2840950 SGTC_1506 4226-2149 212 µM 0.952210697691613 0.164530259830903 no 597 0.170495068358791 186 991114 SGTC_2581 avocatin a 64 µM 0.951636314051999 0.164679239336833 no 598 0.170640729040621 185 6710728 A skin care supplement. SGTC_1166 k206-0078 225 µM 0.949937993615358 0.165120248596778 no 599 0.17107188005604 190 5404595 SGTC_587 k089-0003 57 µM 0.946532571583712 0.166006848543647 no 600 0.171938508644572 181 9659696 SGTC_3318 9139014 38.6185 µM 0.945651141344464 0.166236828699788 no 601 0.172163275220413 221 16643984 SGTC_2602 kawain 100 µM 0.94245320955027 0.167072950315285 no 602 0.172980328029836 201 5369129 SGTC_3098 9119039 49.47 µM 0.942016002853279 0.167187471407523 no 603 0.17309222343063 187 17161528 SGTC_984 1492-0255 2.91 µM 0.939780622513292 0.167773793274042 no 604 0.173665050167795 195 1585198 SGTC_2174 5790901 200 µM 0.937270705920498 0.16843369964198 no 605 0.174309663740988 196 786020 SGTC_53 0973-0023 39.979 µM 0.936879222311324 0.168536778640099 no 606 0.174410344063103 205 674768 SGTC_1709 st033179 39.1045 µM 0.935213979520739 0.168975695916456 no 607 0.174839017772294 192 573381 SGTC_1826 st055655 41.6 µM 0.933044533276104 0.169548609203898 no 608 0.175398487788034 191 676168 SGTC_3159 9100096 49.47 µM 0.932980207201233 0.169565615611888 no 609 0.175415093894603 176 25236875 SGTC_1581 himbacine 57.9 µM 0.931868304627204 0.169859751286649 no 610 0.175702294751631 198 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1619 st003326 88.7 µM 0.92850789467313 0.170750679892361 no 611 0.176572087278794 168 2849032 SGTC_1181 1222-0449 220 µM 0.927866540653548 0.17092105813466 no 612 0.176738401235243 197 658318 SGTC_1866 st057638 64 µM 0.927062227287072 0.171134880856365 no 613 0.176947113237867 180 688802 SGTC_517 1365-0151 113 µM 0.925258738241837 0.171614951015331 no 614 0.177415668126831 184 768657 SGTC_1487 3970-0795 2.82 µM 0.924341729556656 0.171859378899955 no 615 0.177654211384779 200 3765103 SGTC_1513 0337-0559 19 µM 0.923303676303709 0.172136339238003 no 616 0.177924486296572 193 775073 SGTC_2 0422-0095 29 µM 0.920485598356432 0.172889658857859 no 617 0.178659527758587 191 6790840 SGTC_3291 9121177 71.43 µM 0.920359705608265 0.172923361055388 no 618 0.178692409018139 194 17015612 SGTC_1030 k029-0042 36.7 µM 0.920332320461192 0.172930692767763 no 619 0.17869956210408 190 6080581 SGTC_2984 9022109 38.96 µM 0.920031896750075 0.173011136972576 no 620 0.178778045552806 235 6459207 SGTC_1211 1056-0033 32.3 µM 0.919652508094648 0.173112759611557 no 621 0.178877189001977 201 6741922 SGTC_1560 lithocholic acid 53.1 µM 0.917549203037903 0.173676838116612 no 622 0.179427461108578 192 9903 A bile acid which acts as a detergent. SGTC_1154 4088-0362 150 µM 0.916392962451448 0.173987424034373 no 623 0.179730412576857 209 6618304 SGTC_857 0438-0306 1.35 µM 0.912719008306262 0.174976652690342 no 624 0.180695172064234 190 4686136 SGTC_414 piperonyl butoxide 100 µM 0.910866069383777 0.175476915942396 no 625 0.181182972749234 202 5794 A potent inhibitor of cytochrome P450. SGTC_3036 9090181 49.47 µM 0.910681586866883 0.175526772785578 no 626 0.181231584324812 212 25236586 SGTC_1012 4112-3522 18 µM 0.910635460666332 0.175539239904902 no 627 0.181243739963158 197 3112398 SGTC_2295 7971645 200 µM 0.909253892573927 0.175912914132925 no 628 0.181608061283982 190 2978226 YKL099C UTP11 SGTC_1992 st073643 23.3 µM 0.909080789902787 0.175959768887811 no 629 0.181653740971865 212 3161292 SGTC_2605 digitonin 300 nM 0.907441780278204 0.176403801191407 no 630 0.182086611909108 227 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_582 0987-0078 156 µM 0.905333252535515 0.176976074579306 no 631 0.182644432561612 222 1625765 SGTC_956 1185-0240 191 µM 0.903211995832873 0.177552985070492 no 632 0.183206696240566 203 1416193 SGTC_2173 5763948 167 µM 0.901572629300116 0.177999649784439 no 633 0.183641968051556 217 2867177 SGTC_2649 anisomycin 9.56 µM 0.901233851231709 0.178092042119801 no 634 0.183731998037558 203 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1205 4161-2785 76 µM 0.901204997936264 0.178099912453892 no 635 0.183739667046958 185 3498106 SGTC_2915 7971052 15.16 µM 0.901075299791531 0.178135293017809 no 636 0.183774142393294 173 5741558 SGTC_2462 5162487 171.77 µM 0.901058219830558 0.178139952617753 no 637 0.183778682755171 203 2259986 SGTC_2993 9054257 71.4286 µM 0.897227080542335 0.179187070260342 no 638 0.184798878810781 229 6470217 YGL055W OLE1 SGTC_2344 7990960 76.95 µM 0.896122671024008 0.179489642200195 no 639 0.1850936250084 227 140813 SGTC_667 1498-1044 59 µM 0.894965368669946 0.179807049420172 no 640 0.185402800462679 237 6739982 SGTC_442 cape 100 µM 0.891605846420805 0.180730443681486 no 641 0.186302117689502 202 5281787 SGTC_2557 derrustone 83.84 µM 0.89097573779398 0.180903965115566 no 642 0.186471093243474 218 629853 An antioxidant. SGTC_1337 1486-1011 40.3 µM 0.890088929168838 0.181148354275156 no 643 0.186709068509821 207 X1337 SGTC_2309 7664088 163.95 µM 0.889105972945706 0.181419481589642 no 644 0.186973064583642 203 704922 SGTC_2189 6047310 154.431 µM 0.887742085858272 0.181796101044941 no 645 0.187339750943345 204 711535 SGTC_3113 9123498 49.47 µM 0.886390547200444 0.182169792732875 no 646 0.187703555610378 254 8897275 SGTC_1120 ficusin 1.78878 µM 0.883290422673841 0.183028769226864 no 647 0.188539688531933 214 6199 A DNA cross-linker. SGTC_2402 5553605 200 µM 0.881555993735169 0.183510441999228 no 648 0.189008480720771 205 6758546 SGTC_1950 st077106 7.18 µM 0.878904662627795 0.184248275444189 no 649 0.189726485182437 191 13831864 SGTC_1208 2323-2347 50.3 µM 0.878503569960751 0.184360055241688 no 650 0.189835250606869 208 5412760 SGTC_1645 Cervolide 78 µM 0.878135653187375 0.184462626401679 no 651 0.189935053337976 219 23173 A fragrance. SGTC_2784 7567673 72.73 µM 0.877923512971725 0.18452178489779 no 652 0.189992614089749 217 3471247 SGTC_1694 st024011 44.9 µM 0.877312621872251 0.184692206992226 no 653 0.190158429210471 229 2787533 SGTC_1760 st045453 10.4495 µM 0.877045253326983 0.184766826362783 no 654 0.190231029437418 237 3323419 YIL048W NEO1 SGTC_1039 k821-0043 94 µM 0.873658809599158 0.18571356365749 no 655 0.19115204447862 202 15992768 SGTC_907 3448-6986 75.5 µM 0.873491599808389 0.185760387800865 no 656 0.191197591439619 218 590582 SGTC_3057 9095946 49.47 µM 0.873045187685858 0.185885433487557 no 657 0.191319224059355 246 24540043 SGTC_2403 6032726 181.2 µM 0.872566873400716 0.186019473288486 no 658 0.191449601586628 204 2881040 SGTC_454 lyso-paf C-16 6.67 µM 0.870752134238454 0.186528569178616 no 659 0.19194475285703 234 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2488 5268135 45.7 µM 0.869978117628379 0.18674596933371 no 660 0.192156181396791 223 1270356 YLR208W SEC13 SGTC_1079 idarubicin 2.36 µM 0.869248009593272 0.186951180453711 no 661 0.19235574650453 240 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3346 9158254 43.5805 µM 0.868787284522706 0.187080748005228 no 662 0.192481744641144 234 17639500 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.867369874216105 0.187479707839618 no 663 0.192869691354709 198 5379071 SGTC_2128 5255449 168.493 µM 0.866509726537896 0.187722070596601 no 664 0.19310534738516 205 736008 SGTC_1607 st000305 50.6 µM 0.866150603259558 0.187823317566469 no 665 0.193203788958821 213 5457690 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.865936271613508 0.18788375976233 no 666 0.193262555367568 238 5282309 SGTC_2164 5685496 200 µM 0.865774797812672 0.187929303811983 no 667 0.19330683618059 194 759046 SGTC_2873 9040596 71.43 µM 0.865473848111543 0.188014205543085 no 668 0.193389381863844 230 6463863 SGTC_663 1486-0733 13.9 µM 0.863987936895811 0.188433746930304 no 669 0.193797258661268 222 722445 YPR165W RHO1 SGTC_1976 st070609 63.5 µM 0.863081219562699 0.188690038561157 no 670 0.194046406444 208 682556 SGTC_3278 9139605 49.47 µM 0.86216751636615 0.188948522058086 no 671 0.194297671114132 237 7958859 SGTC_196 k015-0023 18.111 µM 0.861733684850823 0.189071327845317 no 672 0.194417042352951 197 5211998 SGTC_2057 5236571 38.335 µM 0.861441535121246 0.189154055102901 no 673 0.19449745418293 202 54684039 YBR257W POP4 SGTC_338 4055-0136 114 µM 0.861399592119951 0.189165933819903 no 674 0.194509000313412 197 2900563 SGTC_676 falcarinol 140 µM 0.860985388669034 0.189283265436128 no 675 0.194623045243308 228 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_672 1441-0018 53.7 µM 0.860582602518101 0.189397405825225 no 676 0.194733985596669 211 251141 SGTC_3136 9095672 49.47 µM 0.854185225511217 0.191215951457702 no 677 0.196501184037353 208 17217380 SGTC_584 0986-0246 15.4 µM 0.854158165531638 0.191223666307458 no 678 0.196508679611197 252 53315 YDR232W HEM1 SGTC_1309 pyrazolanthrone 13.4 µM 0.852731012782987 0.191630820546061 no 679 0.196904244271519 225 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_277 nystatin 15.5 µM 0.851731601055023 0.191916259866103 no 680 0.197181538513827 235 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_699 0375-0592 111 µM 0.851370567606015 0.192019437622883 no 681 0.197281768003279 184 762578 SGTC_1308 1187-1617 41.4 µM 0.851042320197637 0.192113275094266 no 682 0.197372922230664 218 2882570 SGTC_1501 4491-0275 38.4 µM 0.848481296144279 0.192846368882189 no 683 0.198084992289537 225 5104718 SGTC_2158 5657123 3.6195 µM 0.847508954351335 0.193125148943546 no 684 0.198355749081415 230 2858827 SGTC_3038 9091290 49.47 µM 0.844638389618315 0.193949602648909 no 685 0.199156384031526 218 25236843 SGTC_184 1494-0393 24.714 µM 0.843123488451049 0.194385560083282 no 686 0.199579691757581 241 3090647 SGTC_502 l-744,832 89.3 µM 0.841808439464607 0.194764487476592 no 687 0.199947593607947 227 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1450 4112-4260 37.6 µM 0.840247244646163 0.195214923941153 no 688 0.200384886952048 234 1633175 SGTC_2461 5755302 26.15 µM 0.838131728831238 0.195826302431096 no 689 0.200978362409038 239 2788904 SGTC_3142 9086498 49.47 µM 0.838030267577356 0.195855653637527 no 690 0.201006852278806 234 25236367 SGTC_2924 9010168 62.78 µM 0.837079391494206 0.196130857436069 no 691 0.201273971788935 224 2993929 SGTC_485 niflumic acid 177 µM 0.836229476918416 0.196377039204166 no 692 0.201512909281894 223 4488 A COX2 inhibitor. SGTC_166 k072-0058 166.424 µM 0.834349748750764 0.196922176132791 no 693 0.202041962753522 245 5846229 SGTC_2116 5511452 16.8835 µM 0.831914897221813 0.197629663830266 no 694 0.20272849123847 233 870744 SGTC_2922 7999257 32.47 µM 0.831354722446701 0.197792649309973 no 695 0.20288663461497 246 2988377 SGTC_658 3253-0951 102 µM 0.830571595645064 0.198020639815366 no 696 0.203107843226368 224 1184878 SGTC_1326 1431-2094 10.8 µM 0.828874979536805 0.198515117126991 no 697 0.203587577370566 235 616278 SGTC_2879 9041815 71.43 µM 0.82882695660308 0.198529124201371 no 698 0.203601166133357 187 4942971 SGTC_950 1165-0508 94.1 µM 0.828295013495221 0.198684318416927 no 699 0.203751723073678 230 6148369 SGTC_2493 resveratrol 26.09 µM 0.827705773225257 0.198856314433985 no 700 0.203918574401884 201 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2659 sanguinarine 24.21 µM 0.824955250376206 0.199660363600307 no 701 0.204698498503215 237 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1411 3909-8223 150 µM 0.823715696927694 0.200023355737892 no 702 0.205050559142441 234 X1411 SGTC_102 gallobenzophenone 83.616 µM 0.823310376552844 0.200142136208906 no 703 0.205165757144763 227 70837 SGTC_1142 3253-1408 9.78 µM 0.822690743901548 0.200323803523293 no 704 0.205341940158422 231 256655 SGTC_2285 7945142 200 µM 0.821857953168121 0.200568121692584 no 705 0.205578872896561 233 2970608 SGTC_618 k072-0232 33.2 µM 0.821200056165773 0.200761257241943 no 706 0.205766162274408 235 5872756 YGL099W LSG1 SGTC_143 4032-1194 15.74 µM 0.818683139440233 0.201501165729343 no 707 0.206483609346774 232 1806963 SGTC_2630 antimycin a 100 µM 0.81860292300816 0.201524774124836 no 708 0.206506499381316 246 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1364 1653-0028 37.6 µM 0.815612120634562 0.202406175684841 no 709 0.207361007475201 222 5718652 SGTC_281 1672-3440 14.9 µM 0.815251997592049 0.202512460676505 no 710 0.207464039772109 231 6833000 SGTC_70 0141-0289 43.283 µM 0.813384815903523 0.203064066506286 no 711 0.207998731108267 235 352408 SGTC_864 0469-0573 172 µM 0.812043814811096 0.203460780157717 no 712 0.208383245362383 236 689425 SGTC_9 0092-0002 10.449 µM 0.81121806273842 0.203705295494352 no 713 0.208620227232552 249 759368 SGTC_366 0181-0206 4.31 µM 0.810562194125588 0.203899631034002 no 714 0.208808567553474 219 274874 SGTC_1070 indatraline 8.81 µM 0.809760281984279 0.204137389711604 no 715 0.20903898206114 240 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_926 2268-1401 59.4 µM 0.809374744904299 0.204251756233861 no 716 0.20914981223454 252 2931578 SGTC_105 0111-0055 734.78 µM 0.806823568846988 0.205009503469042 no 717 0.209884069143665 216 5179370 SGTC_2241 6772625 37.8075 µM 0.806266853272268 0.205175080298449 no 718 0.210044499245513 230 2285411 SGTC_2862 9027634 71.43 µM 0.805619375456562 0.205367751303886 no 719 0.210231175123538 230 5012562 SGTC_209 4077-0173 175.592 µM 0.805326944255455 0.205454805738539 no 720 0.210315518593417 222 15993494 SGTC_1575 cyproterone acetate 48 µM 0.804135762093909 0.205809637523247 no 721 0.210659286478387 242 9880 An androgen receptor antagonist and liver toxin. SGTC_1627 st003713 25.6 µM 0.803542509378388 0.205986492415223 no 722 0.210830618488932 246 16195070 YER133W GLC7 SGTC_670 4204-0025 119 µM 0.802889035149927 0.2061814042632 no 723 0.211019437089382 218 719039 SGTC_2628 lathosterol 100 µM 0.802245645079652 0.206373415087506 no 724 0.211205438726322 223 6710616 SGTC_1391 3442-0225 151 µM 0.801745603047124 0.206522718834419 no 725 0.21135006530954 228 5227075 SGTC_2045 5106652 78.05 µM 0.799948881951 0.207059715868758 no 726 0.211870207353175 223 673349 SGTC_2113 5491891 107.031 µM 0.797330836181156 0.20784366434629 no 727 0.212629458018476 244 789979 SGTC_656 4090-1979 187 µM 0.795716473122963 0.208327942196755 no 728 0.213098424935959 236 22330961 SGTC_2352 9027995 87.8 µM 0.793945491348927 0.208859967523127 no 729 0.213613582405436 219 2997347 SGTC_2804 7954240 19.48 µM 0.793758383060162 0.208916223936492 no 730 0.213668052321514 228 828705 SGTC_1499 4480-0877 67.3 µM 0.793338471418245 0.209042508037939 no 731 0.213790324095602 231 2861909 SGTC_1458 k015-0034 6.33 µM 0.790541349559337 0.209884860040306 no 732 0.214605841851067 238 3598957 SGTC_3347 9188721 44.724 µM 0.790413091670644 0.209923532623816 no 733 0.214643279518224 253 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2859 9028643 45.46 µM 0.788903370502034 0.210379061550471 no 734 0.215084242806874 206 17151580 SGTC_3020 9089140 49.47 µM 0.788605344816986 0.210469053527917 no 735 0.215171353044984 236 17217859 SGTC_318 1488-0629 67.2 µM 0.784482573050514 0.21171628415894 no 736 0.216378501818045 243 3662576 SGTC_1498 4478-3555 97.6 µM 0.784257093482956 0.211784621293401 no 737 0.216444635157163 231 3437919 SGTC_1656 st012921 11 µM 0.783206251759101 0.2121032749522 no 738 0.216753002130463 237 6732821 SGTC_2988 9073640 71.4286 µM 0.783038745199799 0.212154094962035 no 739 0.216802179991978 246 9102229 SGTC_3198 9112019 49.47 µM 0.783020511179842 0.212159627432165 no 740 0.216807533664859 280 45595555 SGTC_2812 7970281 58.44 µM 0.782978979960419 0.212172228930476 no 741 0.21681972789116 243 2233435 SGTC_3332 9141069 11.198 µM 0.782387680945284 0.212351689699246 no 742 0.21699338569192 236 17332883 SGTC_1438 4092-1045 4 µM 0.781942424848845 0.212486884593665 no 743 0.217124205385843 257 1351342 SGTC_1626 st003712 1.76 µM 0.781566458071531 0.212601080037931 no 744 0.217234702813594 260 24207035 SGTC_3259 9138485 49.47 µM 0.777539303588897 0.213826526723696 no 745 0.21842032761896 220 17646153 SGTC_845 0330-0138 4.51 µM 0.776538134716048 0.214131815515633 no 746 0.218715656720791 248 9039800 SGTC_1885 st057546 99.9 µM 0.776386072632032 0.214178206343747 no 747 0.218760532744191 221 702008 SGTC_394 menadione 8.33 µM 0.774380527955549 0.214790601272333 no 748 0.219352897585301 253 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.774309620707861 0.21481227146986 no 749 0.219373857860143 255 1273210 SGTC_1545 lovastatin 49.4 µM 0.774262330783483 0.214826724605422 no 750 0.219387837463136 244 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2627 acetyl isogambogic acid 100 µM 0.772992094297699 0.215215156062771 no 751 0.21976352969623 247 6857789 A caspase activator and apoptosis inducer. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.77291330796228 0.21523926191706 no 752 0.219786844140659 228 6708561 SGTC_107 0358-0022 2.6945 µM 0.770624551562835 0.215940224766937 no 753 0.220464752170874 243 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2954 9074818 52.69 µM 0.769982262305963 0.216137172017989 no 754 0.220655207285593 254 16648742 SGTC_222 nsc-310342 10.666 µM 0.768905853514296 0.216467467904277 no 755 0.220974601127196 246 432556 SGTC_175 3793-3120 23.7 µM 0.768504216844202 0.216590784844921 no 756 0.221093843196491 268 5322297 SGTC_2208 7283366 200 µM 0.767521177447059 0.216892784795107 no 757 0.22138585344422 251 898663 SGTC_816 0325-0417 81.3 µM 0.767319492065832 0.216954774726983 no 758 0.221445791009724 257 68101 SGTC_767 0929-0023 86 µM 0.763617363097367 0.218094477366141 no 759 0.222547649537269 268 1204563 SGTC_619 1652-1634 108 µM 0.763356451992087 0.218174928973098 no 760 0.222625421819107 246 5400454 SGTC_1163 k060-0048 49.9 µM 0.762779780786151 0.218352805466847 no 761 0.222797370704765 246 6809982 SGTC_194 1486-1323 56.904 µM 0.762172678535724 0.218540158771623 no 762 0.222978475109905 247 5178754 SGTC_445 e6 berbamine 66 µM 0.76173681610355 0.218674724092813 no 763 0.223108548732267 263 6610268 A calcium/calmodulin antagonist. SGTC_548 1436-0017 110 µM 0.761407651329839 0.218776379877256 no 764 0.223206809396695 240 9677137 SGTC_38 0929-0051 58.268 µM 0.76129521972716 0.218811108299816 no 765 0.223240377574295 249 1379719 SGTC_2625 euphol 100 µM 0.760481928075852 0.219062416242715 no 766 0.223483283814027 254 6708538 A triterpene alcohol. SGTC_1245 0418-0076 17.2 µM 0.759343279183621 0.219414538610057 no 767 0.223823617143326 251 6790114 SGTC_815 1582-0027 36.9 µM 0.757458230734988 0.219998196147188 no 768 0.224387690525391 268 3128206 SGTC_1730 st033808 45.1 µM 0.757328193083428 0.220038491832054 no 769 0.224426632132234 260 1045166 SGTC_390 dec-rvkr-cmk 16.7 µM 0.756958568428242 0.220153053152978 no 770 0.224537342385791 234 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1459 k035-0031 35.7 µM 0.756685761137454 0.2202376288749 no 771 0.2246190737009 239 3877128 YMR208W ERG12 SGTC_2262 9014885 67.46 µM 0.756212976928558 0.220384245558421 no 772 0.22476075677706 247 6457424 SGTC_1390 3413-2614 145 µM 0.752834740860336 0.221433508410756 no 773 0.225774613742136 275 3421432 SGTC_1319 1306-0155 43.7 µM 0.752658842956801 0.221488219517568 no 774 0.225827473975982 266 3122360 SGTC_24 0417-1663 219 µM 0.749394083559932 0.222505088809784 no 775 0.226809857952097 271 4329390 SGTC_3188 9110789 49.47 µM 0.749316928656858 0.222529152278317 no 776 0.22683310341011 257 849217 SGTC_3225 9130819 49.47 µM 0.749122802235546 0.222589703989706 no 777 0.226891596338564 276 4547121 SGTC_804 1595-0054 20.9 µM 0.747697780763089 0.22303448267099 no 778 0.227321235032295 248 761523 Stimulates phospholipase C. SGTC_1172 0370-0043 85 µM 0.745965860482138 0.223575731579472 no 779 0.227844019142827 244 376585 SGTC_1905 st060207 84.5 µM 0.744626559176831 0.22399479335468 no 780 0.228248753747981 241 1948547 SGTC_1225 1216-0074 20.6 µM 0.743645348105591 0.224302093220667 no 781 0.228545530412861 259 4241466 SGTC_266 formosanin C 406 nM 0.742646089584315 0.224615291100049 no 782 0.228847988342939 256 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1429 4049-0205 9.46 µM 0.742412124580595 0.224688658643393 no 783 0.228918837868927 241 22774478 SGTC_2751 anetholtrithion 17.25 µM 0.742017149962846 0.224812546965707 no 784 0.229038472419473 253 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2306 7482397 179.52 µM 0.741163611066912 0.225080401476564 no 785 0.229297122063549 270 891448 SGTC_1032 k061-1018 98.7 µM 0.740879229423165 0.225169685247134 no 786 0.229383335172724 244 4005393 SGTC_2126 5251174 33.877 µM 0.740801377407344 0.225194130974613 no 787 0.229406939949108 252 790722 SGTC_2036 5160441 105 µM 0.739749853125037 0.225524459472394 no 788 0.229725896069785 265 134534 YIL048W NEO1 SGTC_1124 fisetin 1.16336 µM 0.739395225371034 0.225635924942466 no 789 0.229833520358421 248 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_346 4513-0042 7.16 µM 0.73831521626363 0.225975581936929 no 790 0.230161461018927 240 2827372 SGTC_2398 5228213 48.84 µM 0.737678691271119 0.226175900896943 no 791 0.230354861948595 261 80771 YMR134W ERG29 SGTC_1418 3966-3099 2.4 µM 0.737648669670324 0.22618535138633 no 792 0.230363985916284 257 740335 SGTC_995 3931-2021 34.6 µM 0.737558572663862 0.226213714331562 no 793 0.230391368819683 255 730143 SGTC_1201 1889-3372 45.9 µM 0.737062174197115 0.226370018846042 no 794 0.230542270293611 243 5392199 SGTC_791 1348-1292 225 µM 0.736426704207256 0.226570202795697 no 795 0.230735529077781 257 5437054 SGTC_3352 9151559 45.5865 µM 0.735962691501975 0.226716437862973 no 796 0.230876701511875 243 17159339 SGTC_2487 5918373 44.05 µM 0.734892129899069 0.227054031844954 no 797 0.231202595897681 267 2876279 SGTC_2406 ethylparaben 405.7 µM 0.734000661233753 0.227335366287614 no 798 0.231474167541485 246 8434 A possible steroid mimic. SGTC_1059 3448-6867 171 µM 0.732405431022032 0.227839287404712 no 799 0.231960572440461 277 3934407 SGTC_745 0469-0705 296 µM 0.729712094105082 0.228691516886411 no 800 0.232783093480015 283 3486736 SGTC_2175 5807670 165.306 µM 0.729350621526298 0.228806030629299 no 801 0.232893607196901 229 241186 SGTC_1717 st033143 58.0435 µM 0.728804545613332 0.228979087342155 no 802 0.233060615311285 256 674616 SGTC_2696 st077691 74.316 µM 0.727833885647771 0.229286880047043 no 803 0.233357639394994 274 757133 SGTC_456 gingerol 170 µM 0.727174203578205 0.229496195129426 no 804 0.233559623376944 288 442793 A herb. SGTC_786 4544-0069 423 µM 0.727103777753945 0.229518547349821 no 805 0.233581192351707 263 748821 YLR208W SEC13 SGTC_1653 st012112 65 µM 0.725914604739797 0.229896159205172 no 806 0.233945561331484 256 720429 SGTC_2413 inermin 26.06 µM 0.724939167233879 0.230206160610021 no 807 0.234244675537064 275 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1974 st069448 26.9 µM 0.724796021122263 0.230251673191291 no 808 0.234288588555341 246 6323587 YNR016C ACC1 SGTC_2263 7948595 193.29 µM 0.724062961255477 0.230484824721112 no 809 0.234513541171349 247 2971371 SGTC_1377 2944-0135 198 µM 0.723504780992112 0.230662443813835 no 810 0.234684908929112 241 1894137 SGTC_608 k048-0125 159 µM 0.723368113903379 0.230705944434596 no 811 0.234726877846369 259 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2341 7987486 176.74 µM 0.719326871313557 0.231994326218102 no 812 0.235969771502003 252 1258686 SGTC_1259 0671-0132 43 µM 0.71842168567133 0.232283455122783 no 813 0.236248659814587 254 X1259 SGTC_1359 1582-0056 520 nM 0.717741805129072 0.232500750216657 no 814 0.236458250784809 270 3661189 SGTC_3176 9106582 49.47 µM 0.717554808276923 0.232560535675172 no 815 0.236515915398434 224 17018027 SGTC_992 3909-8734 162 µM 0.717263357281953 0.232653733596141 no 816 0.236605806184688 260 4288319 SGTC_2667 digitoxin 100 µM 0.715463460402004 0.233229750309305 no 817 0.23716135572559 238 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2946 9065502 71.43 µM 0.715083972569128 0.233351297856399 no 818 0.237278578450219 217 16489101 SGTC_1273 0849-0096 14.1 µM 0.714874576283241 0.233418381203901 no 819 0.23734327399541 269 5286025 SGTC_265 mycophenolic acid 32.932 µM 0.712615831443542 0.234142684877153 no 820 0.238041756276866 268 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_381 3461-2219 42.7 µM 0.712103716770801 0.234307075765939 no 821 0.238200276441626 276 2883159 SGTC_2967 9089538 49.85 µM 0.711557032974374 0.234482633957976 no 822 0.238369560950844 278 728216 SGTC_683 panaxydol 45 µM 0.710524614728579 0.23481437589577 no 823 0.238689436195433 239 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1005 4092-0690 4.4 µM 0.71044195538504 0.234840947633485 no 824 0.238715056779277 273 1529343 SGTC_355 1311-2252 105 µM 0.710035835322514 0.234971523448018 no 825 0.238840957121033 276 5338538 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.709188399749513 0.235244120268713 no 826 0.239103785584592 279 23665772 A membrane-active detergent. SGTC_1876 myriocin 605 nM 0.70802798424279 0.235617677254104 no 827 0.239463939711235 287 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1271 0832-2808 169 µM 0.707399782670947 0.235820042188591 no 828 0.239659035971161 284 3663794 SGTC_2620 irigenin 100 µM 0.707057882695151 0.23593021996783 no 829 0.239765253949211 271 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_955 1216-0110 33 µM 0.706810106862188 0.236010083828523 no 830 0.239842246453259 271 3619719 SGTC_2360 9040895 200 µM 0.706411815762912 0.236138493442165 no 831 0.239966037505451 252 4914414 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.704376029496352 0.236795434525653 no 832 0.240599314858097 260 2333 A French combination drug. SGTC_2102 5377816 72.7585 µM 0.703015853527404 0.237234917997348 no 833 0.241022934845879 264 1379702 SGTC_695 3505-6186 243 µM 0.702883768908261 0.237277619421817 no 834 0.241064093533235 274 1819379 SGTC_1016 4226-1401 38 µM 0.701729495639124 0.237650962148379 no 835 0.241423937444104 273 2901613 SGTC_3100 9120536 49.47 µM 0.69726569140792 0.239097781480423 no 836 0.242818267384233 267 16421196 SGTC_1040 k898-0338 155 µM 0.697172519511661 0.239128031795082 no 837 0.24284741725152 282 20969351 SGTC_3095 9117207 49.47 µM 0.695036926232482 0.239821972461252 no 838 0.243516080284642 249 17015229 SGTC_3120 9124077 49.47 µM 0.693782430394392 0.240230120569441 no 839 0.243909331282889 286 18774327 YGL155W CDC43 SGTC_1210 3013-0140 750 nM 0.691818671339215 0.2408697855943 no 840 0.244525604797567 266 905973 SGTC_3275 9138069 49.47 µM 0.690252147628708 0.241380720831457 no 841 0.245017817374958 275 17617007 SGTC_2310 7668677 200 µM 0.689810378771549 0.241524913922107 no 842 0.245156720491683 280 2197143 SGTC_2395 5646831 180.19 µM 0.689217140219346 0.241718620192829 no 843 0.245343316042595 284 6808628 SGTC_2160 5660466 132.927 µM 0.689112762403294 0.241752710713812 no 844 0.245376154636412 279 2859134 SGTC_2091 4-phenylthiadiazole 200 µM 0.688814829306352 0.241850032088809 no 845 0.245469901186325 272 270010 SGTC_1041 0206-0046 107 µM 0.688344103785623 0.242003840312156 no 846 0.245618057188396 282 50494 SGTC_2112 5488546 200 µM 0.687779569781114 0.242188370133303 no 847 0.245795801760982 289 600757 SGTC_1304 1165-0502 251 µM 0.687678394629693 0.242221449419162 no 848 0.245827664238926 272 767425 SGTC_1443 4112-3303 14 µM 0.687204790203001 0.242376327273502 no 849 0.245976843088793 286 704433 SGTC_616 4092-0450 108 µM 0.684571709828897 0.243238373333418 no 850 0.246807112012491 296 787165 SGTC_3017 9080681 49.47 µM 0.68409602025949 0.24339428624694 no 851 0.246957267376591 289 16451914 SGTC_1500 4488-1866 171 µM 0.683711068116382 0.243520498411389 no 852 0.247078816496185 300 2900003 SGTC_2822 7994718 71.43 µM 0.682875979927654 0.243794415715896 no 853 0.247342606610611 310 1018011 SGTC_2490 carminic acid 95.39 µM 0.681370702327818 0.244288581635764 no 854 0.247818478130667 260 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2382 9035899 200 µM 0.681174984578653 0.244352873240949 no 855 0.247880387324039 285 6462679 SGTC_1111 tnp00062 510.699 nM 0.679639644481825 0.244857535522218 no 856 0.248366330431468 266 676306 SGTC_2014 4013930 200 µM 0.676816728141699 0.245786882721712 no 857 0.249261121585737 284 64556 SGTC_2335 9018011 154.17 µM 0.675466058015748 0.246232212816505 no 858 0.24968985442459 264 6458208 SGTC_1155 4088-0394 48.2 µM 0.675365004521455 0.246265548598887 no 859 0.249721946798202 283 2326248 SGTC_474 dl-dihydrosphingosine 5 µM 0.674696288821722 0.246486207197447 no 860 0.249934371435288 249 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2235 salicylic acid 500 µM 0.674639501465729 0.246504950410703 no 861 0.249952414958175 273 338 A COX inhibitor and kinase inhibitor. SGTC_849 0386-0493 241 µM 0.673246041403691 0.246965114487704 no 862 0.250395387231379 290 726119 SGTC_1796 st049173 110.4 µM 0.673208096523781 0.246977651499051 no 863 0.250407455489399 300 94134 SGTC_41 0478-0632 82.643 µM 0.672924193853274 0.24707146391862 no 864 0.250497759684526 300 3750424 SGTC_2226 7298446 200 µM 0.672200830121125 0.247310577400239 no 865 0.25072792630226 285 3283010 SGTC_183 3914-0051 30.55 µM 0.67094110658256 0.247727283908798 no 866 0.251129024070941 268 1596232 SGTC_630 4356-0227 183 µM 0.670649372453715 0.247823840674318 no 867 0.251221961011811 296 779312 SGTC_779 1360-0071 233 µM 0.670198240121546 0.247973193841646 no 868 0.251365712802708 279 7566 SGTC_1296 1068-0102 11.9 µM 0.668374834685721 0.248577344762512 no 869 0.251947177526544 276 767053 SGTC_2802 7925815 54.55 µM 0.666503393023001 0.249198226044874 no 870 0.252544697825263 278 1262923 SGTC_1648 st011736 69.8 µM 0.665144723592328 0.24964950298351 no 871 0.252978965769091 283 2855514 SGTC_1981 st071826 47 µM 0.665089099167705 0.249667987671614 no 872 0.252996753227237 270 11838600 SGTC_2242 6630449 61.2675 µM 0.663803439637652 0.250095430815804 no 873 0.253408061967147 272 691249 YDR170C SEC7 SGTC_3311 9131146 2.8755 µM 0.663714749088214 0.250124932064726 no 874 0.2534364488378 282 4900406 YPR165W RHO1 SGTC_1094 duloxetine 25.4 µM 0.662012479213291 0.250691517772625 no 875 0.253981612023746 263 60834 A selective serotonin reuptake inhibitor. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.661661042972109 0.250808574858318 no 876 0.254094238386848 242 4000243 SGTC_2506 ethyl hematommate 54.16 µM 0.661348898630336 0.250912568780342 no 877 0.25419429466068 286 3940691 An allergen. SGTC_2034 5197015 53.07 µM 0.660698798675787 0.251129229141802 no 878 0.254402747186194 291 780676 SGTC_2457 5731572 11.68 µM 0.660037618886956 0.251349683568559 no 879 0.254614844282022 293 2865357 SGTC_2052 5265182 7.135 µM 0.658081646313463 0.252002453883712 no 880 0.255242834384356 274 1239884 SGTC_2526 patulin 37.61 µM 0.656762669011672 0.252443143066365 no 881 0.255666765688198 283 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3356 9151811 4.48 µM 0.655421289193166 0.252891733451058 no 882 0.256098274167043 297 1859254 YPR165W RHO1 SGTC_937 3122-0005 46.7 µM 0.654644617783215 0.253151663130761 no 883 0.256348295121574 283 759535 SGTC_1240 0356-0016 42.1 µM 0.653291670490692 0.253604791211184 no 884 0.256784130643017 262 4305613 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.652655808058941 0.253817900849315 no 885 0.256989099149967 310 368090 SGTC_3115 9123671 49.47 µM 0.652165401187406 0.253982325167225 no 886 0.257147238571573 300 3286988 SGTC_728 3030-5151 22.5 µM 0.651927467202242 0.254062120146112 no 887 0.257223982360043 292 3125388 SGTC_3096 9117468 49.47 µM 0.651197164893234 0.25430712084922 no 888 0.257459610126368 288 41316311 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.646691202674795 0.255821509461223 no 889 0.258915908939469 301 689007 SGTC_3050 9093513 49.47 µM 0.646147920902609 0.256004416055934 no 890 0.259091781639405 300 25236664 SGTC_1256 0570-0116 285 µM 0.643163256557058 0.257010478200465 no 891 0.260059086208068 296 410638 SGTC_1207 2099-0101 141 µM 0.64074776332529 0.257826188944726 no 892 0.26084328822945 285 5837381 SGTC_2348 9022543 33.42 µM 0.640667533426255 0.257853305573304 no 893 0.260869356126851 294 3162678 YDL140C RPO21 SGTC_342 k048-0088 23.3 µM 0.639590945628769 0.258217320912594 no 894 0.261219285235901 291 6820570 SGTC_2645 abamectin 100 µM 0.639126076917365 0.258374584399148 no 895 0.261370458531715 276 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_988 1497-1057 103 µM 0.639025468116673 0.258408626541705 no 896 0.261403181992665 301 3533044 SGTC_293 4049-0273 38.5 µM 0.638490485366284 0.258589683118453 no 897 0.26157722285061 281 1380311 SGTC_3108 9121785 49.47 µM 0.638043426635175 0.258741033547366 no 898 0.261722705827695 282 17140271 SGTC_3236 9132701 49.47 µM 0.635067814350828 0.259749585349746 no 899 0.262692093711845 300 24282524 SGTC_778 3456-2434 196 µM 0.634760958681863 0.259853706055356 no 900 0.262792164801375 264 5539063 SGTC_1671 st016596 74.5 µM 0.633971438488738 0.260121700971353 no 901 0.263049730962832 304 2829167 SGTC_1612 st002233 45.4 µM 0.632112402072598 0.260753294968642 no 902 0.263656715866721 276 1035021 SGTC_481 bay k-8644 50 µM 0.631783132028299 0.260865244254218 no 903 0.263764298656794 306 2303 A calcium channel antagonist. SGTC_2910 7948405 25.97 µM 0.631714636640275 0.260888535265895 no 904 0.263786681048276 282 2971328 SGTC_261 5-fluorouridine 15.376 µM 0.630624986357586 0.261259201197738 no 905 0.264142878726883 265 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_872 0588-0139 234 µM 0.630334131929034 0.261358186771346 no 906 0.264237998048825 280 2047100 SGTC_3054 9094397 49.47 µM 0.628711303453751 0.261910832245107 no 907 0.264769038316851 308 2598354 SGTC_717 1532-0246 73.2 µM 0.628381001549284 0.262023388124981 no 908 0.264877189860918 284 9561992 SGTC_2814 7977482 42.97 µM 0.625122507781267 0.263135101546788 no 909 0.265945328315697 289 6456762 SGTC_1035 k081-0041 55.2 µM 0.623736837985238 0.263608585339665 no 910 0.266400213078706 288 731709 SGTC_634 1611-4317 11.2 µM 0.622513120960501 0.264027090975025 no 911 0.266802259398765 314 2843522 SGTC_867 0518-0118 155 µM 0.62069244333517 0.264650380401108 no 912 0.267401001169792 302 6848158 SGTC_1029 k015-0030 64.7 µM 0.619959797184834 0.264901404942135 no 913 0.267642127755847 295 2208316 SGTC_77 0828-0286 12.516 µM 0.619919210788121 0.264915314484635 no 914 0.26765548864777 290 745345 SGTC_2711 st079103 59.1 µM 0.618269662285474 0.2654809524424 no 915 0.268198798251949 303 54693780 SGTC_1967 st070177 51.4 µM 0.617780319481269 0.265648868167665 no 916 0.268360079107707 312 5729214 SGTC_2908 7930301 100 µM 0.616442946720062 0.26610805602663 no 917 0.268801107995824 288 2223178 SGTC_2282 7944268 200 µM 0.616370767406651 0.266132850270794 no 918 0.26882492110529 301 2970414 SGTC_2532 xanthone 78.9 µM 0.615051075324724 0.266586382501942 no 919 0.269260495309141 283 7020 An insecticide. SGTC_1622 st003707 19.4 µM 0.613041010861285 0.267277921856866 no 920 0.269924611527829 296 10140899 SGTC_2275 7947463 200 µM 0.612518432815677 0.267457856914474 no 921 0.270097403138911 295 1225414 SGTC_2003 4023581 200 µM 0.611994101593071 0.267638457008037 no 922 0.27027083003807 307 16641307 SGTC_495 decylubiquinone 155 µM 0.611889133365284 0.267674619536972 no 923 0.270305555837384 319 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_84 0443-0269 128.823 µM 0.611586920483107 0.267778748430063 no 924 0.270405546962632 284 6150058 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.608669249722122 0.268785094327674 no 925 0.271371846625744 286 88881 An O-methylated flavonoid and antioxidant. SGTC_1504 k297-0033 30 µM 0.607577593549042 0.269162109720313 no 926 0.271733832661 260 4388117 SGTC_757 1066-0008 322 µM 0.606541318489558 0.269520243940313 no 927 0.27207767689132 298 6842497 SGTC_591 4299-0174 154 µM 0.605767262236801 0.269787911680784 no 928 0.272334655921791 308 5509088 SGTC_2428 5615643 7.78 µM 0.605548329337548 0.269863642560986 no 929 0.27240736135159 328 2253075 SGTC_60 0986-0278 202 µM 0.605286997519677 0.269954053543799 no 930 0.272494159659218 326 3110598 SGTC_2315 7733312 200 µM 0.60515969449284 0.269998101094827 no 931 0.272536446844831 293 726316 SGTC_866 0495-0101 262 µM 0.601241574046715 0.271355548722373 no 932 0.2738395488997 299 635694 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.600979296838316 0.271446536952609 no 933 0.273926887854321 281 6708739 YPR165W RHO1 SGTC_415 dibenzyl ketone 100 µM 0.600929962308061 0.271463653601914 no 934 0.273943317912615 322 7593 SGTC_1135 dihydrocapsaicin 536.708 nM 0.600155616077187 0.271732383989382 no 935 0.27420126506553 336 107982 A Capsaicinoid. SGTC_1249 0481-0015 10.2 µM 0.599182363402057 0.272070330884985 no 936 0.274525641192448 325 4227577 SGTC_628 1636-0253 16 µM 0.59904192486858 0.272119113234905 no 937 0.274572463684859 295 4456143 SGTC_412 gemfibrozil 100 µM 0.597098964485493 0.272794460599088 no 938 0.275220654614185 296 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_150 3970-0969 77.2 µM 0.595856704774327 0.273226688992231 no 939 0.275635479251244 320 6615640 SGTC_2938 9059746 27.26 µM 0.595369649133369 0.273396246319414 no 940 0.275798204355667 312 6471769 SGTC_1886 st057356 49.9 µM 0.594937471298052 0.273546742802126 no 941 0.275942634323878 302 24207747 SGTC_3339 9145883 14.936 µM 0.59447511431506 0.273707793895513 no 942 0.276097191014226 297 2030670 SGTC_534 k292-0788 63.4 µM 0.594402457009878 0.273733106609044 no 943 0.27612148276139 335 4146317 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.592966335874304 0.274233667132431 no 944 0.276601840892489 303 551469 SGTC_2753 fluvastatin 17.09 µM 0.592779256330468 0.27429890703603 no 945 0.276664445963675 327 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2889 9059656 51.95 µM 0.591950091046311 0.274588152529963 no 946 0.276942004820648 314 3949838 SGTC_1848 st056003 16.4 µM 0.589941472633027 0.275289460806246 no 947 0.277614944238134 283 146492 SGTC_1655 st012546 55.1 µM 0.588332204431833 0.275851971510879 no 948 0.278154666733669 315 720985 YLR208W SEC13 SGTC_2761 levamisole 97.89 µM 0.587837429821126 0.276025030644698 no 949 0.278320708923392 316 26879 An alkaline phosphatase inhibitor. SGTC_731 3966-0296 387 µM 0.586745091885917 0.276407290376487 no 950 0.278687459318593 300 660956 SGTC_1959 st077091 55.8 µM 0.586694923947245 0.276424852700257 no 951 0.278704308758792 313 821356 YKL052C ASK1 SGTC_504 lovastatin 124 µM 0.5850563809894 0.276998759162021 no 952 0.279254903443393 328 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_96 0929-0093 37.281 µM 0.584273032259824 0.277273336234134 no 953 0.279518316409347 306 6991579 SGTC_1349 flufenamic acid 69 µM 0.582402913651181 0.277929382413707 no 954 0.280147659719075 312 3371 A non-steroidal anti-inflammatory. SGTC_253 dyclonine 31.25 µM 0.581524868747372 0.278237665727923 no 955 0.280443381237645 301 3180 An oral anasthetic. SGTC_1540 guanosine 70.6 µM 0.580566345338234 0.278574395443286 no 956 0.280766379979353 314 6802 Guanosine is a purine nucleoside SGTC_2669 eugenol 100 µM 0.579580796381505 0.278920826069945 no 957 0.281098673131777 295 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1263 0774-1208 64.8 µM 0.579266249758905 0.279031436558142 no 958 0.281204767393791 333 906585 SGTC_552 k242-0005 476 µM 0.57885984812505 0.279174379489163 no 959 0.281341872299988 334 4088318 SGTC_33 0986-0033 35.816 µM 0.577794086703536 0.279549406862933 no 960 0.281701574032467 288 2848082 SGTC_1261 0712-0010 12.7 µM 0.575489601796855 0.280361159943084 no 961 0.28248011053111 322 2840123 SGTC_2658 polymyxin b sulfate 77.05 µM 0.574453170298078 0.280726613901447 no 962 0.282830590736722 304 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1895 st058434 18.3 µM 0.574211956533507 0.280811700825146 no 963 0.282912189658529 338 5393175 SGTC_2233 sulbentine 40.3845 µM 0.573983964852817 0.280892135187679 no 964 0.282989326142446 296 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_904 1141-0088 396 µM 0.57372981733002 0.280981810329518 no 965 0.283075323837663 315 1378119 SGTC_2747 doxorubicin 7.63 µM 0.573055457299767 0.281219823148608 no 966 0.283303572585521 267 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2033 5192550 145 µM 0.571111950273425 0.281906320676288 no 967 0.283961879227779 291 182073 SGTC_3213 9129884 49.47 µM 0.56959944027563 0.282441136841785 no 968 0.284474704092672 306 17190742 SGTC_2423 st077119 87.2 µM 0.569361961431474 0.2825251525059 no 969 0.284555262773493 292 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1116 jasmonic acid  1.58368 µM 0.56917375210821 0.282591746050245 no 970 0.284619115755485 343 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2075 5212009 200 µM 0.569077519696368 0.282625798592976 no 971 0.284651766762376 328 780898 SGTC_368 fentichlor 4.58 µM 0.568258596823007 0.282915660217068 no 972 0.284929694092016 346 7329 A pesticide. SGTC_1348 1493-0373 93.8 µM 0.56801215258064 0.283002918257152 no 973 0.285013358054889 339 3010129 SGTC_2380 9035439 200 µM 0.567593437396062 0.283151201554249 no 974 0.285155532159194 309 6462575 SGTC_940 3232-1287 54.8 µM 0.567488553870804 0.283188350718682 no 975 0.28519115049396 334 1585493 YIL048W NEO1 SGTC_643 k048-0106 28.4 µM 0.567243993755542 0.283274981640108 no 976 0.285274211086301 320 6763920 SGTC_2585 alliin 100 µM 0.566863098621204 0.283409932042287 no 977 0.285403598446841 338 87310 A garlic compound which reacts with lipids. SGTC_694 1315-0438 43.2 µM 0.565588030968599 0.283861910157091 no 978 0.285836933074945 315 6793154 SGTC_113 0099-0221 2.5 µM 0.56532439957293 0.283955403614245 no 979 0.28592656781764 312 89219 SGTC_2062 5245942 200 µM 0.56386921923776 0.284471729426715 no 980 0.286421569787322 318 1376160 SGTC_551 k048-0028 34.9 µM 0.563727797276082 0.284521932545149 no 981 0.286469698317519 319 6836383 SGTC_3270 9137563 49.47 µM 0.563191991116375 0.284712175752068 no 982 0.28665207794606 307 17015724 SGTC_979 1426-2828 121 µM 0.563095376363041 0.284746486223461 no 983 0.286684969881944 313 747872 SGTC_3078 9116413 49.47 µM 0.55927338615229 0.286105357274399 no 984 0.287987577843899 307 17177322 SGTC_1489 4065-0444 182 µM 0.557901548273318 0.286593851022051 no 985 0.288455807114719 321 2877968 SGTC_205 1486-1330 71.903 µM 0.55738805592405 0.286776800711611 no 986 0.288631162156114 321 4118834 SGTC_1254 0550-0035 264 µM 0.556472192733301 0.287103246504406 no 987 0.288944049392796 325 15121435 SGTC_1565 sinapyl alcohol 95.1 µM 0.553222138809284 0.288263097601389 no 988 0.290055654553756 328 5280507 A phenol propionate derived from cinnamic acid. SGTC_94 0334-0113 514.748 µM 0.553078932833068 0.288314254501083 no 989 0.290104680893308 318 6795178 SGTC_2464 5717415 7.67 µM 0.552471912964801 0.288531145305608 no 990 0.290312536293069 299 5285744 SGTC_2324 6149169 200 µM 0.551254716260306 0.288966286403512 no 991 0.290729538108536 328 2888231 SGTC_888 0916-0002 6.97 µM 0.550059444320121 0.289393889752031 no 992 0.291139301057308 311 2802138 YIL048W NEO1 SGTC_1662 st014054 52 µM 0.549658081513744 0.289537542195064 no 993 0.291276956656097 319 2838777 SGTC_67 0335-0847 266 µM 0.549498684052369 0.289594601699023 no 994 0.291331633708645 354 4552207 YOR254C SEC63 SGTC_800 3448-7362 155 µM 0.547062315213922 0.290467404881782 no 995 0.292167960612156 317 15991913 SGTC_360 0957-0399 1.01 µM 0.545988594232838 0.290852444477909 no 996 0.292536888737921 318 6752301 YPR165W RHO1 SGTC_2229 7354935 190 µM 0.545726493331941 0.290946470870855 no 997 0.292626978883202 342 318112 SGTC_2874 9043904 71.43 µM 0.544390479467597 0.291425974686182 no 998 0.293086397939055 315 4463428 SGTC_820 1582-0060 59.9 µM 0.543856718879948 0.291617647746956 no 999 0.293270037258516 317 3848840 SGTC_2643 anethole 100 µM 0.543408820783199 0.291778532983334 no 1000 0.293424176893246 347 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2190 6049624 200 µM 0.540910164431882 0.292676809671936 no 1001 0.294284752290683 325 2265554 SGTC_2847 9005661 71.43 µM 0.540548187745685 0.292807048149299 no 1002 0.294409519197244 314 2991449 SGTC_2998 9066762 71.4286 µM 0.540133767393678 0.292956188779508 no 1003 0.29455239247637 353 4945196 SGTC_2221 6807166 181.081 µM 0.539668590226162 0.293123637632063 no 1004 0.294712802495583 310 674925 SGTC_559 1550-0661 158 µM 0.537420614283978 0.293933461676211 no 1005 0.295488553565148 327 5830875 SGTC_682 0kpi-0099 17 µM 0.537344804075401 0.293960790015822 no 1006 0.295514731171867 318 1714895 YML126C ERG13 SGTC_2437 5741531 144.16 µM 0.536005444234354 0.294443800936281 no 1007 0.29597739391281 328 2262990 SGTC_3286 9117135 37.221 µM 0.533841891458117 0.295224811962806 no 1008 0.296725463957061 317 3438150 SGTC_2979 9012552 45.46 µM 0.533570638682006 0.295322797500021 no 1009 0.296819313361321 337 17100905 SGTC_2748 diazoxide 86.69 µM 0.532276892502429 0.295790347484493 no 1010 0.297267117009453 304 3019 A potassium channel activatior. SGTC_1048 3161-0300 24.5 µM 0.529934154577652 0.296637859338213 no 1011 0.29807879227569 313 2165101 SGTC_3019 9081971 49.47 µM 0.529842056652724 0.296671199510398 no 1012 0.298110721546735 333 16451803 SGTC_1998 st075797 76.8 µM 0.527209499817774 0.297624930451097 no 1013 0.299024056188282 322 24208315 SGTC_5 0352-0601 109.883 µM 0.526422320554373 0.297910383748782 no 1014 0.299297405347556 321 762456 SGTC_163 TUB2.036 7.546 µM 0.523967493961439 0.298801373310306 no 1015 0.300150574510524 324 15992207 YJR013W GPI14 SGTC_3205 9113483 49.47 µM 0.522158917019393 0.299458577601608 no 1016 0.300779843873141 374 17018033 SGTC_1246 0422-0085 105 µM 0.522009024278079 0.299513075320157 no 1017 0.300832023681673 372 264295 SGTC_1611 st001856 99.4 µM 0.519915961340008 0.300274536358007 no 1018 0.30156107503065 369 647478 SGTC_1484 3473-2379 286 µM 0.519276791439218 0.300507242105554 no 1019 0.301783867690314 329 671917 SGTC_2388 9080168 200 µM 0.519132911581117 0.300559636385769 no 1020 0.301834029464179 358 15943073 SGTC_1130 3454-2858 15.9 µM 0.518994352858958 0.30061009685694 no 1021 0.301882339637273 345 715628 YIL048W NEO1 SGTC_140 0062-0056 502.533 µM 0.518987462862028 0.300612606163584 no 1022 0.301884742008654 308 3758964 SGTC_2115 tiliquinol 12.7705 µM 0.518044336955333 0.300956177676777 no 1023 0.302213667699434 353 71208 A bioactive hydroxyquinoline. SGTC_705 1124-0212 310 µM 0.517517195387033 0.301148287278723 no 1024 0.302397584252801 375 9554485 SGTC_3167 9103034 49.47 µM 0.517182873516928 0.301270154980143 no 1025 0.302514253168866 330 5127859 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.51508038846404 0.302037065680945 no 1026 0.303248423223641 364 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2763 lisinopril 49.32 µM 0.514361646589709 0.302299437728525 no 1027 0.303499584401221 349 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_808 0711-0032 135 µM 0.513435439741756 0.302637694216459 no 1028 0.303823380234114 347 4252555 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.513275610167647 0.302696082122829 no 1029 0.303879271191572 322 16623 A steroid. SGTC_2603 homopterocarpin 100 µM 0.512400013024716 0.303016039118223 no 1030 0.304185540937233 333 101795 A weak amylase inhibitor. SGTC_3261 9137475 49.47 µM 0.510581850077175 0.303680907375759 no 1031 0.304821943790177 311 17027690 SGTC_1603 st002045 67.8 µM 0.510532401442567 0.303698998910996 no 1032 0.304839260321681 358 5887985 SGTC_1667 st014849 34.6 µM 0.508522395760452 0.304434796835898 no 1033 0.305543518546252 318 5348460 SGTC_994 3910-0338 138 µM 0.507658283663946 0.304751363952073 no 1034 0.305846504379292 328 3479481 SGTC_3241 9133421 49.47 µM 0.507133186454026 0.304943804555618 no 1035 0.306030685504488 356 17018221 SGTC_2323 6148992 148.28 µM 0.506792804896493 0.305068578350284 no 1036 0.306150102668179 320 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_795 0685-0265 78 µM 0.505917997132849 0.305389360905791 no 1037 0.306457108796868 340 302754 SGTC_697 0508-1955 564 µM 0.505453154396371 0.305559874554151 no 1038 0.306620296592259 338 6243113 SGTC_2288 7946289 167.31 µM 0.504889695077785 0.305766619296773 no 1039 0.306818156156882 353 1246052 SGTC_144 4161-2749 112.381 µM 0.504667268603024 0.30584824916775 no 1040 0.306896277039476 323 797501 YMR168C CEP3 SGTC_1941 st076221 61.8 µM 0.50447277119762 0.305919637057026 no 1041 0.30696459582932 311 2828568 SGTC_2212 7123476 200 µM 0.504295790519766 0.305984602053755 no 1042 0.307026767551957 331 1085715 SGTC_2203 7227154 166.4 µM 0.502857927936224 0.306512630046157 no 1043 0.307532081314758 329 896304 SGTC_2955 9076254 12.21 µM 0.5025271122369 0.306634172806989 no 1044 0.307648392938322 322 16459619 SGTC_1711 st032263 62.8 µM 0.501593859757559 0.306977167391477 no 1045 0.3079766197434 355 3958979 SGTC_2098 5376439 882.5 nM 0.501132731689934 0.307146706367464 no 1046 0.308138856169452 351 2844116 SGTC_2746 daunorubicin 9.88 µM 0.500862446560523 0.307246098938113 no 1047 0.308233966691846 317 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2028 5153890 36.43 µM 0.500685600066062 0.307311138769493 no 1048 0.308296204100729 338 2830968 YPR165W RHO1 SGTC_2411 st077133 39.94 µM 0.500398819040396 0.307416622725001 no 1049 0.308397142372582 346 1403142 YNL221C POP1 SGTC_185 k048-0037 25.491 µM 0.50001837325919 0.307556583086704 no 1050 0.308531070168199 326 6827589 SGTC_1400 3771-8998 51.5 µM 0.498122908239023 0.308254313796184 no 1051 0.309198707482077 336 670767 SGTC_850 0388-0143 75.9 µM 0.495119357228569 0.309361356072344 no 1052 0.310257935298632 342 67273 SGTC_2220 6782180 200 µM 0.493396601551999 0.309997108220223 no 1053 0.310866191589112 329 833803 SGTC_659 k018-0002 107 µM 0.490701166458639 0.310992950480344 no 1054 0.31181891068284 348 6797879 YHR007C ERG11 SGTC_1679 SEC14.276 6.7 µM 0.489577341541702 0.31140856306399 no 1055 0.312216506690298 375 1005053 YMR079W SEC14 SGTC_2959 9079155 11 µM 0.488147552717439 0.311937674680591 no 1056 0.312722665358105 368 16189457 SGTC_1187 1391-0724 117 µM 0.488091973708647 0.311958250250185 no 1057 0.312742347989767 342 6997986 SGTC_792 4534-1957 155 µM 0.487533566472713 0.312165007379641 no 1058 0.312940130761756 335 1717904 SGTC_2819 7996655 46.38 µM 0.487047087342243 0.31234518048283 no 1059 0.313112481147542 347 6456960 SGTC_1118 chelidonine 707.474 nM 0.486568829660442 0.312522352426859 no 1060 0.313281958640958 341 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2074 5212007 75.395 µM 0.485286131181935 0.312997745705954 no 1061 0.313736695982283 344 758611 SGTC_362 0310-0100 9.03 µM 0.485275265037001 0.313001774242795 no 1062 0.313740549416578 310 790235 SGTC_1398 3558-0053 112 µM 0.484760924773904 0.313192487338457 no 1063 0.313922971878958 352 4532369 SGTC_770 0389-1121 67.2 µM 0.484112482190439 0.313432995680592 no 1064 0.314153021598144 331 6753108 SGTC_1782 st039423 80.636 µM 0.483153757632087 0.313788733453251 no 1065 0.31449328320585 337 2068169 SGTC_2035 5154463 94.595 µM 0.482944927565183 0.313866243489458 no 1066 0.31456742014973 385 2769623 SGTC_2093 5331342 194.4 µM 0.480567843977971 0.314749107683715 no 1067 0.315411837032962 360 33839 SGTC_316 k060-0003 58.6 µM 0.479655478216979 0.315088247993518 no 1068 0.315736195343007 355 6152314 SGTC_1177 0983-0204 23.6 µM 0.47938596509948 0.315188459989325 no 1069 0.315832038058334 346 766818 SGTC_2927 9011802 47.9 µM 0.478976233048789 0.315340835091273 no 1070 0.315977768352003 343 43912568 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.478880214315017 0.315376548007289 no 1071 0.316011923682368 342 4330530 SGTC_1697 st025554 27.742 µM 0.477954987552394 0.315720762388332 no 1072 0.316341121419553 337 1269519 SGTC_2744 captopril 92.04 µM 0.474368980145783 0.31705638226906 no 1073 0.317618404687768 321 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2654 protoveratrine a 100 µM 0.473573686957298 0.317352915749247 no 1074 0.317901971530175 366 5702278 A heart drug and vasodilator. SGTC_3320 9137005 35.139 µM 0.471551467950114 0.318107449376935 no 1075 0.318623487379764 357 4908713 SGTC_1957 st077035 62.4 µM 0.47121923674651 0.318231484362417 no 1076 0.318742091415125 356 705593 SGTC_3207 9114163 49.47 µM 0.469585159179053 0.318841846313783 no 1077 0.31932571487327 395 849233 SGTC_1475 4092-1048 11.7 µM 0.469379377311748 0.3189187450114 no 1078 0.319399243247562 352 2881759 SGTC_2857 9024691 58.44 µM 0.465647152015086 0.320314791690723 no 1079 0.320734043072818 371 16478292 SGTC_1454 4239-0054 42.6 µM 0.46539873801465 0.320407802081731 no 1080 0.320822968877745 369 1340767 SGTC_2546 rhodinyl acetate 100 µM 0.464930076988319 0.320583307389512 no 1081 0.320990765429719 334 6708682 SGTC_1045 1348-1485 165 µM 0.464136214416707 0.320880686479282 no 1082 0.32127507858415 332 6810614 SGTC_2684 capsaicin 100 µM 0.464120401679985 0.320886611062304 no 1083 0.321280742806773 364 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_356 1634-0012 32.5 µM 0.462869804829085 0.321355318501565 no 1084 0.321728846093834 385 735457 SGTC_467 ro 31-8220 72.8 µM 0.462374143578475 0.321541164697698 no 1085 0.321906519069318 363 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_602 3130-1533 38.1 µM 0.461975111045067 0.321690812807177 no 1086 0.322049584448012 372 720941 SGTC_2619 obliquin 87.91 µM 0.460112066336926 0.322389888091941 no 1087 0.322717891766808 359 6708593 A bioactive alkalod. YER133W GLC7 SGTC_898 1000-0849 28.3 µM 0.459887847957655 0.322474064581617 no 1088 0.322798361567653 363 6751807 SGTC_2863 9028737 58.44 µM 0.459489206871324 0.322623745649359 no 1089 0.322941450475394 377 6460917 SGTC_3330 9141424 71.43 µM 0.458117504585526 0.323139009597731 no 1090 0.323434011783913 335 27261020 SGTC_1176 0848-0131 83.3 µM 0.458062242029367 0.323159775453122 no 1091 0.32345386237682 364 6769040 SGTC_2520 obtusaquinone 4.71 µM 0.457867554279055 0.323232937112073 no 1092 0.323523799215927 384 5967872 SGTC_2120 5538279 151.968 µM 0.457768371864414 0.323270211474863 no 1093 0.323559430483309 336 2058197 SGTC_206 4546-0025 72.014 µM 0.456508297241935 0.323743922337187 no 1094 0.324012252843803 361 6620745 YIL048W NEO1 SGTC_2834 9001755 58.44 µM 0.456332225766489 0.323810137191364 no 1095 0.324075546921235 378 2989575 SGTC_1678 st019265 80.2 µM 0.455863216627247 0.323986543745756 no 1096 0.324244170881544 361 5367020 SGTC_3003 9075612 71.4286 µM 0.455229806508356 0.324224848538629 no 1097 0.32447195953737 370 6501993 SGTC_2671 danthron 100 µM 0.453419355155855 0.324906382683962 no 1098 0.325123400910656 346 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3049 9092223 49.47 µM 0.45297627830413 0.325073265860721 no 1099 0.325282911540524 353 8623917 SGTC_762 1165-0429 115 µM 0.452506810476175 0.325250127394185 no 1100 0.3254519580327 374 5967793 SGTC_1253 0550-0034 176 µM 0.452400108526642 0.325290330466325 no 1101 0.325490384398341 336 5969915 SGTC_522 1273-0010 11.6 µM 0.452253068396808 0.325345735456434 no 1102 0.325543340713763 361 5705015 SGTC_1961 st076550 68.7 µM 0.452194969952102 0.325367628120858 no 1103 0.325564265765297 357 1579337 SGTC_2638 epoxomicin 18 µM 0.451752144626237 0.325534513421944 no 1104 0.325723774200493 384 9915668 A protesome inhibitor. SGTC_333 3486-0131 40.1 µM 0.45172092274423 0.325546281172393 no 1105 0.325735021721103 365 6744690 SGTC_1747 st037496 66.6 µM 0.451190853290025 0.325746094665982 no 1106 0.325926000686218 347 723305 SGTC_801 0866-0028 10.1 µM 0.450938005078492 0.32584142526003 no 1107 0.326017115578189 342 6849771 SGTC_1674 st016616 23.6 µM 0.450582618000043 0.325975435022378 no 1108 0.326145198334753 342 625830 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.448492504110208 0.326764031982798 no 1109 0.326898897383226 345 77254 SGTC_2931 9014674 55.67 µM 0.448456743182978 0.32677753127791 no 1110 0.326911798999576 357 2996810 SGTC_1774 st048371 48.465 µM 0.448284887879254 0.326842407631768 no 1111 0.326973802828317 352 4242727 SGTC_1006 4099-6547 255 µM 0.448017216539582 0.32694346550977 no 1112 0.327070385724273 357 3146833 SGTC_1767 st044992 70.3 µM 0.447976352024018 0.326958894805349 no 1113 0.327085131741145 353 9600693 SGTC_766 1391-0721 126 µM 0.447891876109022 0.326990791480678 no 1114 0.327115615847521 378 1020919 YIL115C NUP159 SGTC_3260 9137109 49.47 µM 0.446102280751529 0.327666809090962 no 1115 0.327761682697886 346 17478346 SGTC_1260 0700-1617 7.75 µM 0.445892856368038 0.327745955901319 no 1116 0.327837321339569 347 2853078 SGTC_2843 9000894 45.46 µM 0.445567759412877 0.327868833654327 no 1117 0.327954751898492 321 2242070 SGTC_2900 5328528 85.29 µM 0.445385713028599 0.327937650347438 no 1118 0.328020517584805 348 795359 SGTC_3263 9137018 49.47 µM 0.444789662412776 0.328163008696032 no 1119 0.328235882855359 355 43844957 SGTC_1779 st039427 55 µM 0.444387209208251 0.328315205974122 no 1120 0.328381329723252 378 1124498 SGTC_1721 st082152 9.2685 µM 0.441964793436452 0.329231901553428 no 1121 0.329257341347271 356 5296051 SGTC_909 3448-9333 149 µM 0.441461928162903 0.329422325852355 no 1122 0.329439308901943 359 3344074 SGTC_2569 tetrandrine 100 µM 0.441097540226438 0.329560339403815 no 1123 0.329571192093725 327 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1103 duloxetine 36.1 µM 0.440664123123229 0.329724528290119 no 1124 0.329728086664777 358 60835 A selective serotonin reuptake inhibitor. SGTC_3029 9088683 49.47 µM 0.440254077889396 0.329879893561032 no 1125 0.329876548337913 329 25236615 SGTC_1660 st012960 28.1 µM 0.43982835080106 0.330041231712025 no 1126 0.330030716170165 376 24207266 SGTC_2044 5102272 200 µM 0.439623088513888 0.330119031430885 no 1127 0.330105057772745 339 592666 SGTC_1797 st048695 56.8 µM 0.439612333505962 0.330123108059799 no 1128 0.330108953191173 383 592262 YIL048W NEO1 SGTC_1846 st056244 14.8 µM 0.437520290045016 0.330916469096985 no 1129 0.330867032276495 370 5393182 SGTC_491 tetrandrine 80.3 µM 0.436808138801877 0.331186710204558 no 1130 0.331125248028492 376 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1392 3455-1037 33.9 µM 0.436069120715599 0.331467239506027 no 1131 0.331393290248176 379 981132 SGTC_3023 9089636 49.47 µM 0.435626714141106 0.331635221131639 no 1132 0.331553792675777 370 17249241 SGTC_957 1187-1561 14.1 µM 0.435194311109317 0.331799437141233 no 1133 0.331710695773134 358 1538454 SGTC_1539 benzyladenosine 56 µM 0.434822690518383 0.331940595307307 no 1134 0.33184556676169 318 92208 A nucleotide analog. SGTC_3237 9133362 49.47 µM 0.434218563125194 0.332170120893904 no 1135 0.332064867157097 391 43845137 SGTC_1849 st056239 19.2 µM 0.434145644800426 0.332197828949433 no 1136 0.332091340661339 349 5393181 SGTC_2987 9018338 71.43 µM 0.433126211332832 0.332585296976653 no 1137 0.33246154077258 378 5055682 SGTC_2193 5925765 200 µM 0.433021279484939 0.332625189817323 no 1138 0.332499655322758 352 877370 SGTC_1031 k035-0009 16 µM 0.431125973757212 0.333346070380219 no 1139 0.333188387838085 384 5180959 SGTC_383 2324-0395 7.37 µM 0.427420861282494 0.334757089171854 no 1140 0.334536407748269 364 3146421 SGTC_3065 9113888 49.47 µM 0.426687216776158 0.335036760915588 no 1141 0.334803581301633 364 16648368 SGTC_1014 4130-3005 69.3 µM 0.426363002260287 0.335160383502479 no 1142 0.334921678147013 374 743608 SGTC_328 k915-0120 63.5 µM 0.425788655605977 0.335379424988509 no 1143 0.335130927013211 340 6624543 SGTC_212 3807-4682 38.772 µM 0.425287883836357 0.335570452529683 no 1144 0.335313412472801 361 3125501 YBL034C STU1 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.42408997777318 0.336027585680077 no 1145 0.335750097178766 352 4174840 SGTC_2445 5742597 35.57 µM 0.423970862900326 0.336073054402241 no 1146 0.335793531455384 357 1774255 SGTC_255 tunicamycin 200.472 nM 0.421850183697809 0.336882964471918 no 1147 0.336567186698838 343 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2792 7535235 81.82 µM 0.420791985956659 0.337287384839786 no 1148 0.336953492078621 351 1281891 SGTC_2504 purpurogallin 52.29 µM 0.420227113901303 0.337503343789198 no 1149 0.337159774574765 371 5281571 An antioxidant. SGTC_837 0091-0265 12.5 µM 0.419744945504354 0.337687726258442 no 1150 0.337335893724047 378 759367 SGTC_2592 piperlongumine 83.33 µM 0.419543934284278 0.337764604990969 no 1151 0.33740932658007 375 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_478 N-arachidonylglycine 10 µM 0.418925322888821 0.338001241508854 no 1152 0.33763535480899 349 5283389 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.418231224505318 0.338266830179472 no 1153 0.337889034212294 362 390807 SGTC_1852 st056254 31.4 µM 0.417273698761246 0.338633348360345 no 1154 0.338239112035965 385 442583 SGTC_3206 9114350 49.47 µM 0.417145639577473 0.338682377981058 no 1155 0.338285941943208 358 17087243 SGTC_3248 9135562 49.47 µM 0.415741803819828 0.3392200393008 no 1156 0.338799473924414 348 17650701 SGTC_1909 st060837 51.5 µM 0.414788819782275 0.339585213634743 no 1157 0.339148252389359 391 678937 SGTC_116 0155-0182 31.788 µM 0.414052460631644 0.339867482587761 no 1158 0.339417843711517 326 771486 SGTC_2944 9067346 25.62 µM 0.412495929931891 0.340464443744948 no 1159 0.339987981642714 369 6473075 SGTC_2183 6420625 130.508 µM 0.410082940449068 0.341390664426212 no 1160 0.340872553253802 368 2897619 SGTC_2362 9071156 126 µM 0.409131904903359 0.341755980329741 no 1161 0.34122143176429 360 653133 SGTC_425 3825-7017 13.1 µM 0.408987862174542 0.34181132358334 no 1162 0.341274284340423 416 3397440 SGTC_1471 k673-0312 37 µM 0.405992023568025 0.342963136269273 no 1163 0.342374230598932 361 24099884 SGTC_2446 5162541 200 µM 0.405682737686688 0.343082131057473 no 1164 0.342487863774853 369 1549321 SGTC_1805 st050013 60.3 µM 0.404339015638265 0.34359929583726 no 1165 0.342981719385973 382 4037144 SGTC_508 roscovitine 141 µM 0.403992099158364 0.343732862862582 no 1166 0.343109264561889 383 160355 A CDKinase inhibitor. SGTC_505 gw-5074 63.9 µM 0.403182931934624 0.34404447779024 no 1167 0.343406827453363 388 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1605 st000082 49.1 µM 0.402203610719418 0.344421761687799 no 1168 0.343767092568756 393 1114022 SGTC_2582 agaric acid 100 µM 0.401849014116119 0.344558408379266 no 1169 0.343897573839739 351 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1677 st019204 53.9 µM 0.401655609283617 0.344632947059116 no 1170 0.343968749049146 356 3945625 SGTC_535 2293-4129 48.2 µM 0.400796744065683 0.34496402858712 no 1171 0.344284888122549 405 396118 YIL048W NEO1 SGTC_3025 9087895 49.47 µM 0.400756140056861 0.344979683853115 no 1172 0.344299836718658 370 17173641 SGTC_1360 1598-0022 39.8 µM 0.400494207336808 0.345080680908148 no 1173 0.344396274579958 404 761525 SGTC_3196 9111891 49.47 µM 0.400097197969706 0.345233782390859 no 1174 0.344542463975625 387 18891510 SGTC_3129 9127257 49.47 µM 0.398358833569691 0.345904457952962 no 1175 0.345182849134963 389 837894 SGTC_1776 st049249 45.9 µM 0.397602395178612 0.346196449408791 no 1176 0.345461647343296 357 1822314 SGTC_2717 st081029 62.2815 µM 0.397591642429849 0.346200600718108 no 1177 0.345465611056219 403 5292846 SGTC_2114 5491910 81.25 µM 0.397334371783643 0.346299930600782 no 1178 0.345560452043615 412 2849228 SGTC_22 0964-0034 14.468 µM 0.396693489856859 0.34654741530937 no 1179 0.345796750738279 394 138402 SGTC_297 0986-0032 24 µM 0.395964597058925 0.34682896615931 no 1180 0.346065572821576 378 2847425 SGTC_2023 5144124 124 µM 0.392607399046515 0.348126847747543 no 1181 0.3473047369313 382 2830192 SGTC_145 3737-0113 38.366 µM 0.391514983015533 0.348549556930919 no 1182 0.347708307958696 400 6849351 SGTC_847 0342-0274 5.54 µM 0.390386447175565 0.348986440203865 no 1183 0.348125404014833 400 18097 SGTC_1495 4469-0029 237 µM 0.389892880866748 0.349177574530273 no 1184 0.348307879200291 379 793680 SGTC_2008 4012253 172 µM 0.38959931347076 0.349291277114789 no 1185 0.348416429938301 372 603940 SGTC_893 0958-0369 48.9 µM 0.389469885408397 0.349341410634158 no 1186 0.348464291757277 404 6819948 SGTC_1345 1488-0192 31.4 µM 0.387833058987011 0.349975656343606 no 1187 0.349069789554941 390 658348 SGTC_2755 lomerizine 42.69 µM 0.387264902440401 0.350195906493225 no 1188 0.349280053020048 366 3949 A calcium channel blocker. SGTC_1081 sertraline 6 µM 0.385384710751241 0.350925135891416 no 1189 0.34997620425361 386 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2558 carylophyllene oxide 100 µM 0.385349992122649 0.350938606631568 no 1190 0.349989063766741 400 6708694 An oxygenated terpenoid and antifungal agent. SGTC_311 1315-0136 58 µM 0.38496639497754 0.351087453821412 no 1191 0.350131156649139 387 6759207 SGTC_1229 0139-0193 12.2 µM 0.384931979160606 0.351100809307243 no 1192 0.350143906056407 380 3090752 SGTC_2178 5812956 200 µM 0.382134425422115 0.35218704860235 no 1193 0.35118082908408 360 5403383 SGTC_3204 9114183 49.47 µM 0.381870341144018 0.352289650216014 no 1194 0.351278770239293 353 17027248 SGTC_1367 1812-0510 76.9 µM 0.38130786843546 0.352508217067379 no 1195 0.351487407875233 362 1142582 YDR527W RBA50 SGTC_2146 5545642 200 µM 0.380878093146037 0.352675252901724 no 1196 0.351646854307757 381 825326 SGTC_2201 6605497 169.863 µM 0.380529012705176 0.352810946903805 no 1197 0.351776382201037 374 670741 SGTC_2051 5263410 176 µM 0.379785924904126 0.35309986116937 no 1198 0.352052165609392 363 227584 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.37959862629038 0.353172696677957 no 1199 0.352121690342522 402 6708760 SGTC_2155 5570423 76 µM 0.379098038801378 0.353367388390287 no 1200 0.352307531304687 394 797402 SGTC_3081 9117243 49.47 µM 0.377843525353506 0.353855470348185 no 1201 0.352773418916945 394 45595589 SGTC_2776 terbinafine 19.92 µM 0.377695548239405 0.35391305829556 no 1202 0.352828387630664 360 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_164 4100-3994 89.624 µM 0.376697860737546 0.354301413451184 no 1203 0.353199076416052 416 4615967 SGTC_2149 5554786 194.827 µM 0.37651396618166 0.354373011937294 no 1204 0.353267417286667 374 745063 YPR165W RHO1 SGTC_480 am 92016 50 µM 0.376388489782533 0.35442186854136 no 1205 0.353314050890279 405 2129 K+ channel blocker. SGTC_574 1315-0397 40 µM 0.376057384075345 0.354550802296821 no 1206 0.35343711769001 376 6794277 SGTC_2011 4012611 177 µM 0.375439260660213 0.354791546374871 no 1207 0.353666905470768 393 2049887 SGTC_151 3013-0144 2.285 µM 0.373580920123561 0.355515673915168 no 1208 0.354358065662644 412 906558 YHR107C CDC12 SGTC_1665 st014639 11.4 µM 0.373204198880621 0.355662532146346 no 1209 0.354498235661746 391 981133 YIL048W NEO1 SGTC_913 3487-1245 167 µM 0.370606825458868 0.356675655169753 no 1210 0.355465198786021 366 4016153 SGTC_3170 9103054 49.47 µM 0.369953398539769 0.356930688344262 no 1211 0.355708606644812 396 16432970 SGTC_2283 7944793 200 µM 0.368400223896266 0.357537150436033 no 1212 0.356287415268216 404 2970533 SGTC_1202 1988-0068 29.6 µM 0.36753417975444 0.357875467739999 no 1213 0.356610300644583 365 2850480 SGTC_2151 5563267 85.4165 µM 0.367347040213115 0.357948587869022 no 1214 0.356680084990457 416 5310824 SGTC_2803 7707263 71.43 µM 0.366185456263793 0.358402564436051 no 1215 0.357113346937648 388 2199229 SGTC_1291 0993-0025 5.79 µM 0.364998924084391 0.358866498117486 no 1216 0.357556104690863 394 4353356 SGTC_1077 5-fluorocytosine 377 nM 0.363689315379391 0.359378796473035 no 1217 0.358045011432619 410 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_199 4063-0024 41.6 µM 0.363679403952325 0.359382674632949 no 1218 0.358048712482943 403 306215 SGTC_2914 7968218 45.32 µM 0.363612907865375 0.359408693708687 no 1219 0.358073543295067 391 2977111 SGTC_3271 9137798 49.47 µM 0.36059848287792 0.360588882898722 no 1220 0.359199811805478 375 6498326 SGTC_1960 st011366 51.8 µM 0.360398377661229 0.360667274034259 no 1221 0.359274619834411 387 3972846 SGTC_2236 dapsone 200 µM 0.360251811357799 0.360724695037942 no 1222 0.359329416113311 370 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3268 9137683 49.47 µM 0.356603485990079 0.362155026334932 no 1223 0.360694333702686 437 1953228 SGTC_1050 3232-1156 69.3 µM 0.354586906766625 0.362946457449024 no 1224 0.361449543243377 383 700529 SGTC_2430 5571206 200 µM 0.352692342317212 0.36369053611946 no 1225 0.362159550430732 396 1731771 SGTC_749 1000-0129 128 µM 0.351318051422255 0.364230602608911 no 1226 0.362674876957782 406 708470 SGTC_1342 1486-1464 234 µM 0.351179776902412 0.364284956444388 no 1227 0.362726740420566 408 3253938 SGTC_3125 9127534 49.47 µM 0.349827634863788 0.364816608806258 no 1228 0.36323402912856 384 1639235 SGTC_2837 9008476 45.46 µM 0.349735477439179 0.364852853909021 no 1229 0.363268612955723 400 2992805 SGTC_1705 st027868 56.3335 µM 0.347382182329496 0.365778802728266 no 1230 0.364152108664324 429 292948 SGTC_3283 9109332 35.8195 µM 0.3443259414261 0.366982506423463 no 1231 0.365300588637867 374 17027281 SGTC_2434 5670830 169.91 µM 0.344250799658005 0.367012117621337 no 1232 0.365328840822764 395 1549830 SGTC_345 1362-0200 395 µM 0.344166675854936 0.367045269318142 no 1233 0.365360470986023 375 1419823 SGTC_2732 terfenadine 20 µM 0.343981424336021 0.367118277146939 no 1234 0.365430127934149 427 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1393 3470-5649 58.2 µM 0.341074556793303 0.368264504591431 no 1235 0.366523727379732 404 4108395 SGTC_1847 st056231 15 µM 0.340666594157056 0.36842546535748 no 1236 0.366677294951702 374 5393180 SGTC_197 4544-0043 41.561 µM 0.338956894978501 0.369100274311539 no 1237 0.367321101353922 397 896523 SGTC_977 1348-1378 135 µM 0.337709812627487 0.369592745639249 no 1238 0.367790939686865 414 X977 SGTC_1657 st012939 43.4 µM 0.337369640361702 0.369727116443983 no 1239 0.367919133986954 397 24207257 SGTC_1078 idebenone 36.1 µM 0.336513038688904 0.370065551493344 no 1240 0.368242010431225 396 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1488 4013-0813 75.9 µM 0.336487675013897 0.370075573971714 no 1241 0.368251572109413 386 2910057 SGTC_2607 solasodine 47.35 µM 0.336355959747777 0.370127622792989 no 1242 0.368301227857923 382 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_490 phenamil 164 µM 0.334318234385629 0.370933156192596 no 1243 0.369069716109271 398 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_606 k015-0008 38.6 µM 0.333753378982605 0.371156549567239 no 1244 0.369282833100485 399 1970475 SGTC_525 k781-2675 26.7 µM 0.333555663280289 0.371234753962356 no 1245 0.36935743969843 399 3651118 YDL195W SEC31 SGTC_2606 farnesol 9.78 µM 0.333405969406003 0.371293967358471 no 1246 0.36941392887808 392 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_118 0083-0097 135.343 µM 0.332373695964228 0.371702379673972 no 1247 0.36980354910239 403 5207356 SGTC_969 1313-0238 134 µM 0.33128147014284 0.37213466903041 no 1248 0.370215943258331 411 5212874 SGTC_3119 9125183 49.47 µM 0.331075581786664 0.372216175147728 no 1249 0.370293697718798 391 22695334 SGTC_417 st075190 100 µM 0.331055002505656 0.372224322291801 no 1250 0.370301469847929 431 222757 SGTC_20 0481-0013 4.944 µM 0.330823306175549 0.372316052638922 no 1251 0.370388977714693 399 182045 SGTC_2866 9034245 58.44 µM 0.32684479649983 0.373892301260624 no 1252 0.37189263789757 436 6462273 SGTC_2377 9073351 62.6 µM 0.325924707226894 0.374257133645217 no 1253 0.372240660919755 414 7337946 YHR072W ERG7 SGTC_1562 morin hydrate 59.1 µM 0.32561739047241 0.374379015521858 no 1254 0.372356926500614 393 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2539 epi(13)torulosol 80 µM 0.324560032010677 0.374798459905475 no 1255 0.372757040357843 384 6708597 SGTC_2941 9056145 11.23 µM 0.323879730678721 0.375068407550171 no 1256 0.373014545069866 438 2119517 SGTC_1968 st069590 43.6 µM 0.32381892600077 0.375092538192466 no 1257 0.373037563357141 407 6384066 SGTC_2749 bexarotene 57.39 µM 0.322126629023755 0.375764330598531 no 1258 0.373678382773514 389 82146 An retinoic acid receptor inhibitor. SGTC_952 1185-0122 232 µM 0.320883838323364 0.376257922234164 no 1259 0.374149210985057 404 678600 SGTC_2379 9035213 200 µM 0.320303737995891 0.376488386513229 no 1260 0.374369044900775 434 646551 SGTC_214 4373-3496 70 µM 0.320104961384551 0.376567367311651 no 1261 0.374444382376051 417 3779166 SGTC_1882 5615643 20 µM 0.319767700391237 0.376701384547732 no 1262 0.37457221719149 399 2253075 SGTC_3155 9099265 49.47 µM 0.319674306506054 0.376738499058252 no 1263 0.374607619484078 423 25236499 SGTC_960 1222-0186 7.7 µM 0.319666881688332 0.376741449712258 no 1264 0.374610434013157 405 3126296 SGTC_978 1416-0512 87.4 µM 0.317495699594803 0.3776045949006 no 1265 0.375433751021403 400 6814003 SGTC_920 mycophenolic acid 780.421 nM 0.316812567511765 0.377876298157333 no 1266 0.375692913787424 389 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2780 5215298 71.43 µM 0.31629338041957 0.37808283572237 no 1267 0.375889917557926 415 2834131 SGTC_923 1900-2434 73.3 µM 0.315729826690467 0.37830706219898 no 1268 0.376103792714849 445 5910570 SGTC_75 0159-0059 199.013 µM 0.314754104952339 0.378695378755322 no 1269 0.376474180351538 443 5377270 SGTC_2678 equilin 100 µM 0.312611601241814 0.379548479107157 no 1270 0.377287881541838 388 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1723 st034307 2.5525 µM 0.311262694333163 0.380085887002652 no 1271 0.377800462595723 391 867466 SGTC_283 0987-0079 11.7 µM 0.308093855851361 0.381349269674062 no 1272 0.379005458156229 426 411556 SGTC_1559 coumarin 343 70.1 µM 0.308087540876898 0.381351788655974 no 1273 0.379007860693174 398 108770 A hepatotoxic, DNA x-linker. SGTC_1637 st007924 17.4 µM 0.307160217706495 0.381721743360426 no 1274 0.379360712208951 398 683336 SGTC_110 0850-0284 111.64 µM 0.307051003702024 0.38176532130387 no 1275 0.379402275354049 405 3906265 SGTC_730 1436-0052 41.2 µM 0.306451643251316 0.382004501323602 no 1276 0.379630396410466 388 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_418 lividomycin a 100 µM 0.306217559171085 0.382097926855287 no 1277 0.379719501939679 398 72394 An antibiotic. SGTC_2686 alizarin 95.37 µM 0.302718614706958 0.383495209537579 no 1278 0.381052155266305 365 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_276 colchicine 750 µM 0.302384901291997 0.383628555511501 no 1279 0.381179331687411 436 2833 A microtubule depolymerizer. SGTC_1322 1348-1070 12 µM 0.302282783277507 0.383669362817521 no 1280 0.381218250888869 411 6758089 SGTC_2587 piperic acid 92.2 µM 0.302161412877317 0.383717865233492 no 1281 0.381264509118974 416 5370536 SGTC_1018 4259-0013 28.1 µM 0.30195680091184 0.383799637026415 no 1282 0.381342497273279 408 6801262 SGTC_3199 9111318 49.47 µM 0.301749662348023 0.383882423828076 no 1283 0.381421453352465 427 8548020 SGTC_720 r052-1644 49.9 µM 0.30125096321393 0.38408175999714 no 1284 0.38161156532245 413 1422863 YOR257W CDC31 SGTC_301 4119-0100 24.5 µM 0.301183116940194 0.384108881357152 no 1285 0.381637431599597 433 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1188 1403-0014 4.57 µM 0.300689209922931 0.384306336414786 no 1286 0.381825748737553 398 9614867 SGTC_1840 st055363 71 µM 0.30023479522636 0.384488029682531 no 1287 0.381999032927152 403 676033 SGTC_2400 5203494 178.7 µM 0.296488945691012 0.385986734384771 no 1288 0.383428353872064 403 6777674 SGTC_3288 9119690 36.221 µM 0.293974683610927 0.38699364087453 no 1289 0.384388624305346 435 17595618 YKL019W RAM2 SGTC_2677 mitomycin C 100 µM 0.293796882811115 0.387064875060754 no 1290 0.384456558591664 422 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3046 9092212 49.47 µM 0.292508965403326 0.387580980254387 no 1291 0.384948753043335 426 25236637 SGTC_605 1315-0399 119 µM 0.292150745942174 0.387724564357064 no 1292 0.385085684284181 403 24020461 SGTC_1213 1315-0166 115 µM 0.291793508682486 0.387867770058644 no 1293 0.38522225434573 383 768401 SGTC_1873 rapamycin 2 nM 0.291635435393807 0.387931141767272 no 1294 0.385282689537298 411 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.291589209393371 0.387949674372169 no 1295 0.385300363367277 392 5711223 A potent inhibitor of glutathione S-transferases. SGTC_813 k007-0158 173 µM 0.291407074183633 0.38802269723044 no 1296 0.385370002398536 420 6523916 SGTC_1530 rhein 70.4 µM 0.290153938258132 0.38852522002181 no 1297 0.385849236488962 416 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1791 st048313 56.1 µM 0.289942623978439 0.388609978037583 no 1298 0.385930066147955 418 1204976 SGTC_1056 3448-1962 115 µM 0.289693221974207 0.388710019837338 no 1299 0.386025471084189 417 715507 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.289544942575992 0.388769502160364 no 1300 0.386082196376251 459 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3336 9143619 71.43 µM 0.288818145066198 0.389061094882443 no 1301 0.386360272909216 416 45595730 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.286613101080137 0.389946145064862 no 1302 0.387204290956245 410 5106787 A p450 inhibitor. SGTC_135 0933-0004 26.348 µM 0.285491080504791 0.390396715848444 no 1303 0.38763396846313 440 21230617 YGL099W LSG1 SGTC_1892 st058411 7.36 µM 0.285474324003518 0.390403445888716 no 1304 0.387640386405728 408 3934738 SGTC_1859 st055998 20 µM 0.284645958208386 0.39073618960649 no 1305 0.387957698761092 418 676301 SGTC_3026 9090633 49.47 µM 0.284094415796825 0.39095778138179 no 1306 0.388169013144103 394 25236842 SGTC_2303 7774051 200 µM 0.283489178980363 0.391200986564638 no 1307 0.388400937756951 428 2953184 SGTC_1977 st070720 65.3 µM 0.283182390469802 0.391324281103586 no 1308 0.388518513235648 399 682188 SGTC_739 1486-1183 203 µM 0.28137054023698 0.392052663791869 no 1309 0.389213105615493 441 4346692 SGTC_1441 4106-0040 13 µM 0.280323083499405 0.392473925128249 no 1310 0.389614821188801 406 2904180 SGTC_2469 5655019 90.81 µM 0.28021833361936 0.392516059892999 no 1311 0.389655000854729 447 2788239 SGTC_747 3448-8087 38.7 µM 0.279558649543057 0.392781441237866 no 1312 0.389908067712651 424 5168703 SGTC_2883 9059145 45.46 µM 0.278020995258771 0.393400210596357 no 1313 0.390498120991259 450 16476510 SGTC_1226 3909-7979 35.4 µM 0.278015764611701 0.393402315928047 no 1314 0.390500128610073 431 6615510 SGTC_2600 tangeritin 87.95 µM 0.27691579254529 0.393845123052082 no 1315 0.390922382959155 420 68077 A bioactive flavone. SGTC_1916 st067606 49.2 µM 0.275382770291373 0.394462488687364 no 1316 0.391511089931075 412 19590279 SGTC_1521 st012942 49.4 µM 0.274151425294147 0.39495855756097 no 1317 0.391984127718426 438 24207259 SGTC_1494 4358-1428 177 µM 0.274041210684601 0.395002967761255 no 1318 0.392026475944438 430 1564571 SGTC_2394 5221648 200 µM 0.272410979895755 0.395660016786153 no 1319 0.392653015548286 429 788586 SGTC_2648 atorvastatin 78.68 µM 0.272348317041495 0.395685278386168 no 1320 0.392677104058356 441 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1699 st031318 29.054 µM 0.272231972577247 0.395732182092879 no 1321 0.392721829648085 445 5340658 SGTC_2961 9083290 32.55 µM 0.270596116875365 0.396391828966317 no 1322 0.393350841364237 433 17741490 SGTC_536 3852-0578 10.6 µM 0.27048547766913 0.396436454151876 no 1323 0.393393393915732 407 2869208 SGTC_782 0083-0095 30.5 µM 0.262898238980286 0.399499895568574 no 1324 0.396314506837501 415 3591729 An indicator and reagent. SGTC_980 1473-0395 201 µM 0.262700596796544 0.399579779685837 no 1325 0.396390678380483 454 768876 SGTC_17 0960-0276 49.807 µM 0.262582359413497 0.39962757153906 no 1326 0.396436249105616 421 6821114 SGTC_1636 st007707 68.9 µM 0.26245300688096 0.399679857886783 no 1327 0.396486105421519 466 403051 SGTC_2312 7706453 155.7 µM 0.261807106796767 0.399940967859515 no 1328 0.396735079849084 426 976098 SGTC_1436 4092-1007 8.32 µM 0.261771617243287 0.399955316076587 no 1329 0.39674876119122 411 2881121 SGTC_2491 paeonol 100 µM 0.26136217705282 0.400120860093036 no 1330 0.396906610948453 430 11092 Increases levels of cortical cytochrome oxidase. SGTC_716 1683-5115 658 µM 0.260409924494728 0.400505942259069 no 1331 0.397273794167361 449 723597 SGTC_1917 st066507 28.5 µM 0.257244477066576 0.40178671327328 no 1332 0.398495025611909 426 3156428 SGTC_45 0kpi-0036 14.9 µM 0.256906358541557 0.401923581975904 no 1333 0.398625530942958 449 2795021 SGTC_1864 st057645 30.4 µM 0.25650804283244 0.402084833631142 no 1334 0.398779285431034 444 688666 SGTC_3217 9129673 49.47 µM 0.256487278690568 0.402093240114549 no 1335 0.39878730106189 391 17248312 SGTC_1683 st010134 710 nM 0.255234935846309 0.402600341990725 no 1336 0.399270824748732 419 3818134 SGTC_2782 7736369 71.43 µM 0.253326063363689 0.403373602622548 no 1337 0.400008128580525 425 2950836 YOL077C BRX1 SGTC_1602 st001878 87.6 µM 0.253074475116898 0.403475546162462 no 1338 0.400105331435774 459 595405 YLR310C CDC25 SGTC_154 3389-1638 511.116 µM 0.251423061188974 0.404144861488688 no 1339 0.400743519981457 457 5238686 SGTC_1712 st032288 53.4 µM 0.250965349779867 0.404330420928297 no 1340 0.400920449431992 439 2883011 SGTC_62 0180-0423 3.232 µM 0.249216926545672 0.405039441866542 no 1341 0.40159649346427 459 30102 YGL099W LSG1 SGTC_1752 st044819 83.042 µM 0.247758337133976 0.405631168018102 no 1342 0.40216069607357 413 441209 YML126C ERG13 SGTC_2736 butenafine 14.65 µM 0.24719607208518 0.405859327540598 no 1343 0.402378242509619 431 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_545 4218-0007 221 µM 0.247042135952519 0.405921798312903 no 1344 0.402437807341661 438 2840508 SGTC_1267 0828-0272 9.49 µM 0.247040995420562 0.405922261175569 no 1345 0.402438248673367 435 745334 SGTC_2911 7942208 15.64 µM 0.246496885372021 0.406143092619856 no 1346 0.402648807593957 417 1243384 SGTC_2264 7948757 110.76 µM 0.246478777141906 0.406150442504699 no 1347 0.402655815576613 421 2971411 SGTC_597 k018-0003 82.8 µM 0.246411626442971 0.406177698350757 no 1348 0.402681803532079 448 6786234 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.245885775286678 0.406391152171007 no 1349 0.402885327762126 441 279621 SGTC_3024 9090631 49.47 µM 0.245180322715242 0.406677553593924 no 1350 0.403158405839059 441 25236383 SGTC_3124 9127567 49.47 µM 0.244310083885762 0.407030924123431 no 1351 0.403495337128438 427 17592030 SGTC_1597 7-benzyloxygramine 47.5 µM 0.243260402267239 0.407457260162798 no 1352 0.403901838774348 447 260807 SGTC_247 mechlorethamine 29.705 µM 0.240405607310145 0.40861730967587 no 1353 0.405007915825994 431 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2284 7945075 39.21 µM 0.239768942558467 0.408876128808864 no 1354 0.405254692488108 455 1245402 SGTC_1934 st074720 32.6 µM 0.239660478606945 0.408920225910355 no 1355 0.40529673779485 416 17250992 SGTC_564 3555-0129 330 µM 0.238370157736613 0.409444907017571 no 1356 0.405797005538972 453 563260 SGTC_3097 9117246 49.47 µM 0.23805781659021 0.409571938222736 no 1357 0.405918125869612 412 16423892 SGTC_581 0958-0271 211 µM 0.236157148087472 0.410345156846939 no 1358 0.406655364991398 413 4591145 SGTC_3355 9151058 44.0485 µM 0.234971184689608 0.410827800243675 no 1359 0.407115549212719 432 17015728 SGTC_2345 9052315 157.45 µM 0.234487809930262 0.411024554735074 no 1360 0.407303147844114 420 6469265 SGTC_422 cantharidin 155 µM 0.234345618332267 0.411082437145758 no 1361 0.407358336713857 421 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3243 9134147 49.47 µM 0.232919731900665 0.411662984359528 no 1362 0.407911867975138 449 24282180 SGTC_1505 k297-0037 20.6 µM 0.232617153865704 0.411786203409347 no 1363 0.408029352908682 412 4089396 SGTC_2838 9002687 71.43 µM 0.231572071119898 0.412211859974028 no 1364 0.408435200952413 442 6457060 SGTC_2095 5432005 200 µM 0.230205285679969 0.412768700119691 no 1365 0.408966127386648 475 783734 SGTC_87 0100-0052 35.5 µM 0.229204490658949 0.413176544040897 no 1366 0.40935499122157 440 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_875 0709-0210 25.7 µM 0.227685549719309 0.413795721674485 no 1367 0.409945353531359 458 6251364 SGTC_1318 1280-3875 124 µM 0.227373143737273 0.413923096770312 no 1368 0.410066800807522 437 373245 SGTC_2699 st077704 54.6 µM 0.227363067276856 0.413927205325544 no 1369 0.410070718157467 419 645852 SGTC_1335 1486-0900 202 µM 0.226371821906703 0.41433141965197 no 1370 0.410456120992286 431 X1335 SGTC_1131 3454-3128 32.3 µM 0.225681027374768 0.414613168522018 no 1371 0.410724757691518 398 710982 SGTC_269 exalamide 29 µM 0.224829901221794 0.414960370975683 no 1372 0.411055801852882 426 3316 A derivative of salicylamide. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.223876235737881 0.415349481517813 no 1373 0.411426803775667 426 5357218 A potent inhibitor of glutathione S-transferases. SGTC_56 0957-0365 83.25 µM 0.223168401764584 0.415638342639853 no 1374 0.411702221763284 451 6752360 SGTC_291 SEC14.278 35.5 µM 0.22253033422082 0.41589877174442 no 1375 0.411950530946447 437 1068044 SGTC_763 3453-1109 128 µM 0.222464228187781 0.415925755225674 no 1376 0.411976258665181 461 1560353 SGTC_403 arphamenine a 50 µM 0.221103031888094 0.416481462863024 no 1377 0.412506104787062 471 5487158 An arginine aminopeptidase inhibitor. SGTC_3299 9121982 43.1275 µM 0.221071737691397 0.416494240669202 no 1378 0.412518287942821 433 17594604 YPL160W CDC60 SGTC_1310 1188-0297 994 nM 0.220374210700834 0.416779072415041 no 1379 0.41278986429978 444 1588352 SGTC_2070 5230947 200 µM 0.220274883587102 0.416819635715116 no 1380 0.412828539887619 459 2835538 SGTC_687 k029-0044 34.9 µM 0.220151301716473 0.416870105431958 no 1381 0.412876660875461 467 5829338 SGTC_3093 9117344 49.47 µM 0.215335065514643 0.418838071899551 no 1382 0.414753046246486 414 24824913 SGTC_3030 9087619 49.47 µM 0.214785734699275 0.419062664512212 no 1383 0.414967187702288 472 25236973 SGTC_931 2812-0076 566 µM 0.213953688384355 0.419402894904256 no 1384 0.415291586092186 465 3450959 SGTC_2820 7989630 71.43 µM 0.212278230915012 0.420088185479566 no 1385 0.415944988818727 446 2984098 SGTC_350 k064-0020 19.8 µM 0.211651870578183 0.420344439847741 no 1386 0.416189319530384 433 2790705 SGTC_426 0988-0037 14.6 µM 0.210772388075924 0.420704307646276 no 1387 0.416532442818481 470 5383008 SGTC_1792 st045773 43.6 µM 0.210738784573524 0.420718058887716 no 1388 0.416545554228013 443 2919270 SGTC_192 3455-0609 60.9 µM 0.209835537746912 0.42108772218565 no 1389 0.416898017684011 427 3769639 SGTC_2536 dehydroabietamide 32.04 µM 0.208100929897216 0.421797823603445 no 1390 0.41757508055059 433 3983547 SGTC_68 0986-0284 82.829 µM 0.206989816494847 0.422252817095103 no 1391 0.418008905770278 441 423278 YIL048W NEO1 SGTC_2917 7979103 53.79 µM 0.206342695423451 0.422517856695991 no 1392 0.418261614960984 466 2980565 SGTC_3238 9133470 49.47 µM 0.206278629824551 0.422544097778015 no 1393 0.418286635247666 464 3534688 SGTC_3303 9125618 40.5795 µM 0.205864336775781 0.422713799293791 no 1394 0.418448441929804 447 22695467 SGTC_1346 1488-2224 62.4 µM 0.205241005494484 0.422969153460935 no 1395 0.418691916774535 446 3722427 SGTC_1003 4049-0218 100 µM 0.205158745057515 0.423002854727631 no 1396 0.418724050247134 468 295161 SGTC_280 3448-3607 3.04 µM 0.204429167322235 0.423301779958664 no 1397 0.419009069600713 460 626179 SGTC_263 alizarin 107.927 µM 0.203376478582199 0.423733169175159 no 1398 0.419420391499579 473 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1558 st069300 45.6 µM 0.203286185959434 0.423770175130707 no 1399 0.419455676057348 456 24208000 SGTC_835 0312-0010 67.2 µM 0.203241314497148 0.42378856571311 no 1400 0.419473211171605 434 1626196 SGTC_1129 3453-1384 223 µM 0.203035605914032 0.423872877562357 no 1401 0.419553601137835 465 1084452 SGTC_1740 st038286 13.222 µM 0.20297761746966 0.42389664537244 no 1402 0.419576263361447 431 716786 SGTC_3314 9135860 59.4275 µM 0.202671550424829 0.424022098112747 no 1403 0.419695880572446 476 25252478 SGTC_29 0299-0004 12.984 µM 0.201731601266496 0.424407418633858 no 1404 0.420063278113443 478 16871 A napthoquinone isolated from Swertia calycina. SGTC_2467 5474540 200 µM 0.200815318666398 0.424783106899434 no 1405 0.420421492181395 426 5413519 SGTC_1497 4476-2978 41.3 µM 0.200041094402984 0.425100602602032 no 1406 0.420724220960889 477 1528379 SGTC_3141 9094609 49.47 µM 0.199962316142364 0.425132910902787 no 1407 0.420755026613634 461 25236309 YDL196W YDL196W SGTC_91 0417-1751 58.384 µM 0.198781952534471 0.425617058128643 no 1408 0.421216657026763 479 6795624 SGTC_755 1995-0008 37.3 µM 0.197493010204217 0.426145868957496 no 1409 0.421720875388448 437 689533 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.19742145372319 0.426175230138719 no 1410 0.421748871170831 448 15053 SGTC_738 1315-0003 72.4 µM 0.197241160998725 0.426249209980821 no 1411 0.421819410711988 477 6251474 SGTC_620 0109-0052 432 µM 0.196661668100414 0.426487011921845 no 1412 0.422046154327332 468 493037 SGTC_2143 5623677 140.463 µM 0.194518789637599 0.427366599592131 no 1413 0.42288484235101 463 5375313 SGTC_2369 9071472 200 µM 0.194483219006624 0.427381203334283 no 1414 0.422898767082056 439 17296037 SGTC_520 3584-0023 682 µM 0.193348488085388 0.427847126233407 no 1415 0.42334302734302 415 1340790 SGTC_2136 5328288 199.296 µM 0.192505113443797 0.428193482857335 no 1416 0.423673281436035 444 262395 SGTC_127 0180-0333 59.125 µM 0.192448042108647 0.428216922882792 no 1417 0.423695631737949 451 771601 SGTC_3138 9097216 49.47 µM 0.192360132402381 0.428253029170243 no 1418 0.423730059456875 480 25237486 SGTC_458 nppb 133 µM 0.190806157569529 0.428891376822066 no 1419 0.424338732138648 435 4549 A chloride channel blocker. SGTC_777 1315-0167 517 µM 0.190121088056329 0.429172851451367 no 1420 0.424607122787562 466 4221767 SGTC_2296 7971656 126.45 µM 0.189813077289707 0.429299415634359 no 1421 0.424727803999361 449 666570 SGTC_2232 chlorophetanol 41.5365 µM 0.18976392046755 0.429319615253869 no 1422 0.424747064709354 468 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_947 3447-0010 211 µM 0.189669378475746 0.429358465158136 no 1423 0.424784108819045 452 748350 SGTC_2825 7998094 58.44 µM 0.189230437436459 0.429538847058683 no 1424 0.424956106487708 477 2987815 SGTC_1092 toremifene 6.32 µM 0.188893026758628 0.429677515272929 no 1425 0.425088329516645 482 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_98 0074-0023 107.663 µM 0.186802746041716 0.430536766448588 no 1426 0.425907646894229 468 3563821 SGTC_2273 7815444 169.05 µM 0.185219140474481 0.431187958058122 no 1427 0.426528578450923 495 2824616 SGTC_2726 cimetidine 79.27 µM 0.185140800827066 0.4312201768354 no 1428 0.426559300158235 482 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2482 5981709 142.65 µM 0.183038455179726 0.432084979617282 no 1429 0.427383922709966 466 877755 SGTC_2012 4023501 200 µM 0.182927694804461 0.43213055011337 no 1430 0.427427376112151 466 3477460 SGTC_530 4358-1714 28 µM 0.181693321104748 0.43263847341215 no 1431 0.427911703858516 475 1564641 SGTC_812 4251-0442 148 µM 0.181272574573575 0.432811628771237 no 1432 0.428076815856307 479 5723007 SGTC_799 1310-0557 151 µM 0.181250225847267 0.432820826597946 no 1433 0.428085586436407 475 5354492 SGTC_1170 0310-0127 64.8 µM 0.181157489743081 0.432858993395185 no 1434 0.428121980363317 471 774975 SGTC_1214 0358-0031 63.7 µM 0.18095811529196 0.432941050765988 no 1435 0.428200226168633 468 4301366 SGTC_2728 chlorpromazine 9.18 µM 0.178467483757149 0.433966372897845 no 1436 0.429177927716084 495 2726 A thorazine and dopamine antagonist. SGTC_2800 7887935 81.82 µM 0.176720138932471 0.434685970748068 no 1437 0.429864110632627 456 2961002 SGTC_701 4424-0219 185 µM 0.173714176610506 0.435924402107264 no 1438 0.431045047799706 452 2911779 SGTC_870 0573-2213 57.6 µM 0.173075444153273 0.436187635921223 no 1439 0.431296063188478 470 3916321 SGTC_1757 st041620 31.8375 µM 0.172503637968313 0.436423312126416 no 1440 0.43152080077452 458 5289815 SGTC_3123 9126162 49.47 µM 0.1719448692473 0.43665363660369 no 1441 0.431740435649397 469 25239884 SGTC_2502 avocadyne acetate 18.59 µM 0.1718717093718 0.436683794697501 no 1442 0.431769194120139 452 3952079 SGTC_2657 nystatin 74.44 µM 0.17183995029816 0.436696886593805 no 1443 0.431781678430966 447 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1926 methyl fluorone black 53.6 µM 0.171308543973265 0.436915956045056 no 1444 0.431990581326601 467 72721 Reacts with homocysteine. SGTC_109 0132-0036 33.701 µM 0.170324127539904 0.437321827586068 no 1445 0.432377618726713 494 67274 A color developer. SGTC_2594 a-mangostin 100 µM 0.170215416032786 0.437366653022532 no 1446 0.432420364196442 479 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2840 9008771 71.43 µM 0.168452712984872 0.43809358699442 no 1447 0.433113570783982 474 2992978 SGTC_42 0133-0086 60.653 µM 0.167898323793703 0.438322258906439 no 1448 0.433331634414454 497 162923 Model of phenazepam hydroxylation. SGTC_3202 9113761 49.47 µM 0.167702729673427 0.438402941591021 no 1449 0.433408574318798 484 4798415 SGTC_822 1487-0950 154 µM 0.167215920761103 0.438603761649392 no 1450 0.433600078915753 486 1958375 SGTC_1269 0831-0796 3.05 µM 0.167187160413968 0.438615626460082 no 1451 0.433611393368266 482 927758 SGTC_2339 9000433 200 µM 0.166903692765086 0.43873257132204 no 1452 0.433722913751073 446 2988954 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.166816313059992 0.438768620985756 no 1453 0.43375729128903 460 2724278 An inhibitor of dopamine biosynthesis. SGTC_2103 5378138 10 µM 0.166214401745906 0.439016961318497 no 1454 0.433994113071522 479 244142 SGTC_161 4065-0411 162.148 µM 0.16597461007919 0.439115902755877 no 1455 0.434088465618178 468 1906281 YLR208W SEC13 SGTC_88 0180-0332 8.668 µM 0.165746094896194 0.439210194896433 no 1456 0.4341783846205 443 3101745 SGTC_1175 0741-0056 27.6 µM 0.165596934576355 0.439271744728346 no 1457 0.434237079919595 465 765927 SGTC_2718 lomofungin 53.02 µM 0.165050389563562 0.439497284760882 no 1458 0.434452160374692 479 5351222 A RNA synthesis inhibitor. SGTC_178 4092-0806 87.505 µM 0.16442753119631 0.439754340589883 no 1459 0.434697295880258 464 2169044 SGTC_1369 1866-0067 208 µM 0.16310763120254 0.440299151754225 no 1460 0.435216845716051 468 3531355 SGTC_1690 st023502 41.2 µM 0.162671661297065 0.440479130632829 no 1461 0.435388480377677 488 24207482 SGTC_2340 7987427 183.45 µM 0.162389739070396 0.440595521468462 no 1462 0.435499475314966 461 2239331 SGTC_377 3970-0964 33.1 µM 0.161374278867361 0.441014793956945 no 1463 0.435899311818853 468 16481235 SGTC_1479 0549-0158 134 µM 0.161138547787478 0.441112134233168 no 1464 0.43599214009678 450 5440202 SGTC_787 4152-0075 138 µM 0.159153580052143 0.441931926159888 no 1465 0.436773937682062 468 9566539 SGTC_1925 st057770 10.1 µM 0.158457731410502 0.442219370809502 no 1466 0.437048062624503 422 5989122 SGTC_2165 5727197 32.143 µM 0.158009190471093 0.44240467248828 no 1467 0.437224778373288 474 1361712 SGTC_3146 9095609 49.47 µM 0.156302529888633 0.44310984465728 no 1468 0.437897281143425 467 17173999 SGTC_654 1124-0271 80.9 µM 0.155594003506663 0.443402652533452 no 1469 0.43817652594169 477 5403748 SGTC_326 k292-0812 17.5 µM 0.153991523877812 0.444065012139327 no 1470 0.438808209417405 483 3579357 SGTC_2720 fluspirilene 36.88 µM 0.153117755043336 0.444426236617023 no 1471 0.439152707240466 462 3396 An atypical antipsychotic. SGTC_1242 0402-0103 60.1 µM 0.151146041186046 0.445241531343438 no 1472 0.439930257024711 460 432868 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.149473574029821 0.445933270651032 no 1473 0.440589979983856 475 688664 SGTC_3191 9110352 49.47 µM 0.149424444081538 0.445953593499011 no 1474 0.440609362331897 478 17122424 SGTC_3178 9107506 49.47 µM 0.149083214549016 0.44609474871089 no 1475 0.440743985358381 473 8897194 SGTC_1132 3456-3614 2.5 µM 0.148821506643144 0.446203013123344 no 1476 0.440847239885792 449 3125502 SGTC_2694 st077685 81.9 µM 0.147938504135027 0.446568326813101 no 1477 0.441195650309412 441 2838096 SGTC_2239 6685329 187.64 µM 0.147723134308995 0.446657435994792 no 1478 0.441280636702371 418 805680 SGTC_37 0566-0070 1.56 µM 0.147252217596837 0.44685228697858 no 1479 0.441466473042931 498 1626686 SGTC_453 enantio-paf c16 10 µM 0.144712149084461 0.447903510002862 no 1480 0.442469073276499 495 13871343 A lipid and platelet activating factor SGTC_711 k292-0785 179 µM 0.144384707018341 0.448039050708812 no 1481 0.442598346151519 496 4146315 SGTC_3077 9117319 49.47 µM 0.143662247470381 0.448338125588624 no 1482 0.442883592016906 495 17154678 SGTC_300 r073-0011 5.04 µM 0.143291391122233 0.44849165953525 no 1483 0.443030027281108 474 2735780 SGTC_74 000s-0487 160.283 µM 0.143157555345245 0.448547069232769 no 1484 0.443082875200569 426 677548 SGTC_1192 1488-0095 21.4 µM 0.142727302016069 0.44872520632533 no 1485 0.443252776786498 475 915875 SGTC_352 k048-0007 5.11 µM 0.142335091222473 0.448887601736172 no 1486 0.44340766494889 501 6811911 SGTC_2361 9034121 116 µM 0.142108856533842 0.448981278411896 no 1487 0.443497011337785 470 6496917 SGTC_104 0074-0074 590.992 µM 0.141162920948688 0.449372991361802 no 1488 0.443870618748717 467 3943124 SGTC_2085 5307070 144.047 µM 0.14084188365741 0.449505944485837 no 1489 0.443997427228173 480 2840351 SGTC_3127 9126946 49.47 µM 0.140798525665555 0.449523901029279 no 1490 0.444014553905825 490 27243249 SGTC_2882 9058044 58.44 µM 0.138677196262494 0.450402566871833 no 1491 0.444852619352519 463 18076804 SGTC_3047 9092122 49.47 µM 0.138545813976888 0.450456994148773 no 1492 0.444904532193413 475 17173831 SGTC_1072 oxiconazole 14.9 nM 0.138026784645833 0.450672019703827 no 1493 0.445109624530311 489 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1899 st063254 59.6 µM 0.137599117644784 0.450849206188871 no 1494 0.445278626456494 496 3093813 SGTC_2524 avocatin b 10.57 µM 0.137566849928553 0.450862575406861 no 1495 0.445291378150946 496 6710748 SGTC_860 0443-0016 25.1 µM 0.135977708165282 0.45152106014769 no 1496 0.445919451786298 453 5337942 SGTC_1356 1502-0781 85.8 µM 0.134050930218318 0.452319628284864 no 1497 0.446681150669362 465 567702 SGTC_2370 9071495 200 µM 0.133930988799616 0.452369345352505 no 1498 0.44672857275793 490 21791103 SGTC_95 0471-0001 561.058 µM 0.133079153079575 0.452722462285589 no 1499 0.447065390960486 488 4015405 SGTC_910 3454-3003 490 µM 0.129093356525535 0.454375212456302 no 1500 0.448641889373716 502 820824 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.128967399117477 0.454427454979654 no 1501 0.448691722545654 454 94937 An inhibitor of serotonin biosynthesis. SGTC_3116 9124943 49.47 µM 0.12839834156911 0.454663489039148 no 1502 0.448916871765447 492 41905195 YPL160W CDC60 SGTC_1811 st050069 61.5 µM 0.126860848759805 0.455301291128547 no 1503 0.449525267187578 509 3877702 SGTC_2707 st078556 66.6 µM 0.1257945310936 0.455743702194292 no 1504 0.449947285469929 495 17250899 SGTC_1790 st045711 43.5 µM 0.125549165553453 0.455845511192841 no 1505 0.450044402219329 487 585119 SGTC_1785 bathophenanthroline 24 µM 0.124587600132312 0.456244519358332 no 1506 0.450425022782651 471 72812 An iron chelator. SGTC_1299 1079-1439 3.74 µM 0.123456150647007 0.456714078563038 no 1507 0.450872947654487 467 323161 SGTC_585 0kpi-0023 191 µM 0.123000807816304 0.456903066018975 no 1508 0.451053229140131 491 64601 SGTC_769 0302-0231 76 µM 0.122962846957473 0.456918821898633 no 1509 0.451068259239271 496 571869 YER009W NTF2 SGTC_1613 st002381 52.1 µM 0.122747053443714 0.457008389562718 no 1510 0.451153701154509 473 551167 SGTC_3001 9076041 71.4286 µM 0.120840007377406 0.457800026132491 no 1511 0.451908880486772 471 16004211 SGTC_2077 5212015 200 µM 0.120207005568416 0.458062829570859 no 1512 0.452159584188966 495 780900 SGTC_1733 st037357 54.9 µM 0.119585504767133 0.458320875973504 no 1513 0.452405751417348 504 1272339 YGL099W LSG1 SGTC_660 4031-1742 102 µM 0.119580009608852 0.458323157635274 no 1514 0.452407928049594 482 6738706 SGTC_1384 3089-0840 101 µM 0.118735924229598 0.458673649213265 no 1515 0.452742287220346 474 1069836 SGTC_3087 9117406 49.47 µM 0.11858615358377 0.458735842198558 no 1516 0.452801617888445 465 42546093 SGTC_2185 6113692 200 µM 0.118126885359452 0.458926561841876 no 1517 0.452983560575532 480 874150 SGTC_3040 9091894 49.47 µM 0.117942819282806 0.459003001348439 no 1518 0.453056482559549 486 25236966 SGTC_2332 7982454 138.89 µM 0.117450318455813 0.459207535999677 no 1519 0.453251605798869 510 2981748 SGTC_2918 7977171 22.06 µM 0.116802160999651 0.459476730999405 no 1520 0.453508415622797 492 2236483 SGTC_1855 st056195 39.6 µM 0.116350800125471 0.459664202742784 no 1521 0.453687263143743 499 4028379 SGTC_997 3996-0078 137 µM 0.11623433419613 0.459712578066963 no 1522 0.453733413203874 475 735687 SGTC_1350 1495-0454 146 µM 0.11616978929043 0.459739387715726 no 1523 0.453758989633279 500 1069057 SGTC_1137 ixabepilone 100 µM 0.114288882185087 0.460520729253027 no 1524 0.454504397740808 498 154225 A novel microtubule stabilizer. SGTC_2433 5607874 27.82 µM 0.11388876673236 0.460686959686381 no 1525 0.454662985237016 511 2252428 SGTC_2004 4023728 41.89 µM 0.112981285262873 0.46106400387805 no 1526 0.455022696199506 513 360084 YDR527W RBA50 SGTC_753 1322-0200 289 µM 0.112356892134258 0.461323449691838 no 1527 0.455270216963343 487 5403907 SGTC_1279 0874-0590 65.2 µM 0.112170228984998 0.461401014561264 no 1528 0.455344216998144 480 3523074 SGTC_3045 9092950 49.47 µM 0.110903073392524 0.46192759935303 no 1529 0.455846604212186 487 44120432 SGTC_215 1287-0124 461.5 µM 0.110390488482819 0.462140630421608 no 1530 0.456049848059343 492 5560863 SGTC_176 1486-1328 72.834 µM 0.11013503233667 0.462246802443749 no 1531 0.456151142677443 470 22310231 SGTC_962 1254-0300 21.5 µM 0.109842800357964 0.462368262440626 no 1532 0.456267023308296 501 7340576 SGTC_2139 5578692 56.4705 µM 0.109243271170981 0.462617454948023 no 1533 0.456504770115586 500 650991 YMR113W FOL3 SGTC_217 ketoconazole 989 nM 0.10859336911732 0.462887601356291 no 1534 0.456762510164344 488 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1588 farnesol 29.9 µM 0.108381774831297 0.462975558980899 no 1535 0.456846428772976 475 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_512 prima-1 270 µM 0.108048458998709 0.463114118702854 no 1536 0.456978626230231 472 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2216 7189485 200 µM 0.108014516093694 0.463128229053457 no 1537 0.456992088701582 496 731273 SGTC_1461 k072-0203 53.8 µM 0.106612754071536 0.463710993605772 no 1538 0.457548099985705 498 5418714 SGTC_21 0849-0113 22.993 µM 0.105727026845938 0.464079263549239 no 1539 0.457899468103688 490 1560156 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.105657916082513 0.4641079998987 no 1540 0.457926885740947 479 2724 A muscle relaxant with antifungal properties. SGTC_1978 st071761 42 µM 0.105445121085658 0.464196481523072 no 1541 0.458011307075571 461 5147680 SGTC_3287 9117173 37.0625 µM 0.105344641408343 0.464238262280246 no 1542 0.458051170647282 506 2789709 SGTC_3076 9116187 49.47 µM 0.101208258526408 0.465958561042706 no 1543 0.45969257051375 501 27241210 SGTC_2807 7945238 51.95 µM 0.101176545174453 0.465971752949253 no 1544 0.45970515769966 507 17148797 SGTC_1640 st009078 66.4 µM 0.100700907275352 0.466169610076455 no 1545 0.45989394556759 502 690618 SGTC_742 0kpi-0133 140 µM 0.0997653894998354 0.466558793617779 no 1546 0.460265293050285 511 2728852 SGTC_1027 k015-0025 8.67 µM 0.0994487086676342 0.466690542864674 no 1547 0.460391005242914 454 3598955 SGTC_2716 st080858 38.6235 µM 0.0988145236607527 0.466954394853928 no 1548 0.460642768359626 510 5296050 SGTC_2779 methotrexate 400 µM 0.0981401708168282 0.467234974556772 no 1549 0.460910494885936 514 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_665 3914-0008 307 µM 0.0978353736198379 0.467361797652487 no 1550 0.461031509012682 481 1069549 SGTC_2083 5306046 65.942 µM 0.0977877491784182 0.467381614010627 no 1551 0.461050417748363 493 539837 SGTC_2968 9090663 33.37 µM 0.0977262663876724 0.467407196897432 no 1552 0.46107482891217 509 25236811 SGTC_2553 4-methylesculetin 85.09 µM 0.0971483369126844 0.467647678955294 no 1553 0.4613042975314 461 5319502 SGTC_528 3492-0019 172 µM 0.0969764929646916 0.467719187169648 no 1554 0.461372531171187 515 2869262 SGTC_840 0245-0196 390 µM 0.0968038425655727 0.467791032015882 no 1555 0.461441086171599 499 3827528 SGTC_2213 7173844 200 µM 0.0964545793857826 0.467936373775963 no 1556 0.461579773032763 495 892728 SGTC_2818 7996756 12.99 µM 0.0964164732359162 0.467952231460528 no 1557 0.461594904662602 514 2241621 SGTC_2894 9048625 32.47 µM 0.0953926975837127 0.468378289557421 no 1558 0.462001458056524 512 4092861 SGTC_1140 3229-1848 2.98 µM 0.0951983037485666 0.468459193290112 no 1559 0.46207865864103 506 2849525 SGTC_2849 9019321 12.99 µM 0.0945674507703959 0.468721753579608 no 1560 0.462329202228537 511 16489627 SGTC_1227 3909-8010 46.6 µM 0.0936571832499366 0.469100629830686 no 1561 0.462690741764956 506 15982272 SGTC_245 methotrexate 289.6 µM 0.0935925802244866 0.469127520303267 no 1562 0.46271640193281 518 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0932958250357666 0.469251043992273 no 1563 0.462834274378628 521 688667 SGTC_1186 1319-0216 26 µM 0.0928700671167998 0.469428269947812 no 1564 0.46300339296465 499 4565136 SGTC_2549 cedrol 20.94 µM 0.0918724017461202 0.469843581716393 no 1565 0.463399709460256 499 6708665 A sedative which affects the nervous system. SGTC_1750 st081859 2.357 µM 0.091340691329491 0.470064937493466 no 1566 0.463610943051139 509 5291695 SGTC_2646 retinol 96.75 µM 0.089826656341562 0.470695294175143 no 1567 0.464212482558352 503 445354 A vitamin A analog and teratogen. SGTC_1930 st074634 34.3 µM 0.0896765523090134 0.470757792847567 no 1568 0.46427212469975 458 684253 YOR116C RPO31 SGTC_884 0851-0618 334 µM 0.0891774326775428 0.470965615981846 no 1569 0.464470450011767 516 9642473 SGTC_432 NS 1619 61.3 µM 0.0890444143796973 0.47102100339814 no 1570 0.464523306357951 489 4552 A K+/calcium channel activator. SGTC_1217 1183-1422 255 µM 0.0884732574256425 0.4712588334875 no 1571 0.464750269227871 498 2849664 SGTC_677 0929-0063 136 µM 0.0877304970381926 0.471568134666784 no 1572 0.465045439969169 513 1539583 SGTC_1919 st067113 52.3 µM 0.0866997601629551 0.471997383735392 no 1573 0.465455083531667 509 1268243 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.0859180537943831 0.472322946080108 no 1574 0.465765779863467 522 7104 SGTC_1404 3909-7820 48.3 µM 0.0857231395973117 0.472404126154541 no 1575 0.465843253548019 511 23741373 SGTC_3335 9143315 29.6265 µM 0.0849493288371371 0.472726422908659 no 1576 0.466150837373531 501 4899691 SGTC_249 wiskostatin 11.211 µM 0.0847779555428515 0.472797803321081 no 1577 0.466218959681178 517 2775510 A n-wasp and actin depolymerizer. SGTC_2785 7756463 72.73 µM 0.0845720059540547 0.472883586608803 no 1578 0.466300827662267 524 2201551 SGTC_1108 betulinic acid 729.144 nM 0.0843996941583723 0.472955359859139 no 1579 0.466369325223176 484 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_378 3970-0959 8.33 µM 0.0827147288086489 0.473657246523934 no 1580 0.467039186555405 512 6615653 SGTC_496 calpeptin 138 µM 0.082150116328451 0.473892459063141 no 1581 0.467263670350311 504 73364 A calpain inhibitor. SGTC_2366 9070441 60.58 µM 0.0821099052184214 0.473909211002214 no 1582 0.467279658249313 487 6837235 SGTC_108 0509-0257 621.132 µM 0.0820240116613792 0.473944994392564 no 1583 0.46731380962246 481 536624 SGTC_948 3448-0295 75.3 µM 0.0784922885915978 0.475416494444189 no 1584 0.468718232055672 489 678569 SGTC_1942 st076330 65.2 µM 0.0779599631341705 0.475638318573991 no 1585 0.468929950406181 515 24208414 SGTC_2415 st077333 57.7 µM 0.0769674339499956 0.47605193326308 no 1586 0.469324726017366 526 2766255 SGTC_2238 6671620 73.2395 µM 0.0762512415656818 0.476350406728126 no 1587 0.469609608221009 479 729941 SGTC_2651 TUB2.036 5 µM 0.076054434004826 0.476432428689785 no 1588 0.469687895743936 493 15992207 YFL037W TUB2 SGTC_930 2810-3379 265 µM 0.0758286908702359 0.476526511135582 no 1589 0.469777694909626 501 1015764 SGTC_441 propafenone 146 µM 0.0755072590507974 0.476660475790781 no 1590 0.469905561069681 520 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2522 biochanin a 4.94 µM 0.0754906921012739 0.476667380548073 no 1591 0.469912151516424 509 5280373 A possible chelator. SGTC_236 1509-0011 5.31 µM 0.0747564967101147 0.476973384801688 no 1592 0.470204227755502 523 3107280 SGTC_3307 9126885 69.2785 µM 0.0723594899393157 0.477972523432142 no 1593 0.471157911296729 492 24824909 SGTC_2940 9060638 45.86 µM 0.0723452262128133 0.477978469367976 no 1594 0.471163586825538 491 4027022 SGTC_156 3474-0145 5.642 µM 0.0723295323197635 0.47798501148457 no 1595 0.471169831423585 510 2265471 SGTC_681 1642-0006 26.6 µM 0.0716492189258711 0.478268610885042 no 1596 0.471440534829354 522 4446530 SGTC_1806 st050005 60.3 µM 0.07150938176082 0.478326905587551 no 1597 0.4714961790548 504 5194765 SGTC_431 k089-0097 107 µM 0.0711694281980691 0.478468625865364 no 1598 0.471631456231563 512 5499420 SGTC_2904 7225135 42.03 µM 0.0709431309677283 0.478562966455808 no 1599 0.47172150814148 518 4446116 SGTC_3187 9109394 49.47 µM 0.0701287348262016 0.478902488302362 no 1600 0.472045597957838 516 17098090 SGTC_2202 7226349 200 µM 0.0699585876605803 0.478973424617237 no 1601 0.472113310549254 501 844334 SGTC_2476 5806916 10.51 µM 0.0698509219601332 0.479018312033179 no 1602 0.472156158130193 517 2870194 SGTC_1932 st074806 40.9 µM 0.0692983924886381 0.479248673880905 no 1603 0.472376052635874 522 17251235 SGTC_983 1491-0821 12.2 µM 0.0689531446363783 0.479392618926815 no 1604 0.47251345792142 504 46495113 SGTC_1042 0350-0096 82 µM 0.068528653916059 0.479569606580678 no 1605 0.472682405579079 482 3122515 SGTC_2974 9094440 9.66 µM 0.0684164812440483 0.479616376659108 no 1606 0.472727051217485 513 25236134 SGTC_1658 st012944 20 µM 0.0668131028140158 0.480284931126167 no 1607 0.473365246090939 515 24207260 SGTC_2495 cafestol 54.53 µM 0.066352907440626 0.480476827327015 no 1608 0.473548430974185 499 16667697 An anti-infammatory. SGTC_2624 nerol 100 µM 0.0656933084313992 0.480751880439275 no 1609 0.473811000002365 511 637566 A natural product oil. SGTC_1 0258-0098 57.368 µM 0.0650532324729011 0.481018801192242 no 1610 0.474065808295811 492 6790032 YDR047W HEM12 SGTC_1751 st044839 27.194 µM 0.0644764674755903 0.481259327668984 no 1611 0.474295422174519 517 5291326 SGTC_1822 st052468 42 µM 0.0639314806416779 0.481486608069542 no 1612 0.474512392808204 519 2873678 SGTC_2304 7443016 91.4 µM 0.0633300385519768 0.481737439457853 no 1613 0.474751848230016 532 939854 SGTC_3114 9122766 49.47 µM 0.0631085164971332 0.481829827044942 no 1614 0.474840046317698 525 17176985 SGTC_1642 st009582 77.7 µM 0.0630043959316131 0.481873251716893 no 1615 0.474881501915399 516 6739311 SGTC_3285 9112818 20.8695 µM 0.0617481842510202 0.482397185957564 no 1616 0.475381683833698 520 17017947 YPR165W RHO1 SGTC_1024 4507-0395 26 µM 0.0616931775418122 0.482420128571386 no 1617 0.475403586577327 493 4201836 SGTC_1507 4075-3230 155 µM 0.0608613323207653 0.482767087913804 no 1618 0.475734822334183 512 659771 SGTC_1466 k213-0079 57.5 µM 0.0598734690544848 0.483179138695371 no 1619 0.47612820530132 519 3657981 SGTC_420 mitomycin C 81.9 mM 0.0593429243288418 0.483400443333014 no 1620 0.476339486332693 500 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_244 nsc-207895 1.295 µM 0.0591832339434921 0.483467055541274 no 1621 0.476403081803776 512 42640 SGTC_604 1000-0114 314 µM 0.0577316563780303 0.484072578094129 no 1622 0.476981188798217 517 1572745 SGTC_2053 5265679 138 µM 0.0569113609794027 0.484414778942572 no 1623 0.477307902114839 518 764595 SGTC_2507 purpurin 79.67 µM 0.0568656774208451 0.484433836993177 no 1624 0.477326097750729 532 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1953 st076800 12.1 µM 0.0558355675248435 0.484863582719208 no 1625 0.477736400170533 509 297591 SGTC_3166 9102297 49.47 µM 0.0548604840580548 0.485270388486406 no 1626 0.478124806797936 515 25237072 SGTC_1963 st076565 50.3 µM 0.0545714861793983 0.485390961645666 no 1627 0.478239927814339 515 4914280 SGTC_3043 9092303 49.47 µM 0.0543204478556542 0.485495698736901 no 1628 0.478339929285174 522 25236084 SGTC_2326 6164455 177.58 µM 0.0537953663452562 0.485714774132577 no 1629 0.478549100648267 507 2888790 SGTC_486 niguldipine 82 µM 0.0536568971204622 0.485772547217817 no 1630 0.478604262207207 516 1236 A calcium channel blocker. SGTC_1090 efavirenz 20.7 µM 0.0528544994262871 0.486107334960327 no 1631 0.47892391894266 500 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_80 0159-0065 512.242 µM 0.0513884779814931 0.486719034333662 no 1632 0.479507982941066 524 1548079 SGTC_1807 st050092 58.9 µM 0.0509597160787356 0.486897941770846 no 1633 0.479678810364067 511 5008496 SGTC_423 5-fluorouracil 457 µM 0.0505896175880971 0.487052373127175 no 1634 0.47982626809855 526 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1616 st002734 56.1 µM 0.0499307203207828 0.487327316619671 no 1635 0.48008879827597 522 4026101 SGTC_2463 5473429 200 µM 0.0495934042399158 0.487468073619773 no 1636 0.480223201410047 515 5399405 SGTC_2181 6316240 54.2555 µM 0.048808221507397 0.487795724750481 no 1637 0.480536065084927 512 12779990 SGTC_211 3455-0679 143.504 µM 0.0484791613398155 0.487933041663891 no 1638 0.480667185876596 499 748649 SGTC_868 0527-0199 213 µM 0.0478829239415783 0.488181855354387 no 1639 0.480904774249935 527 2849450 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.0477866440486609 0.488222034005127 no 1640 0.480943140450709 520 688664 SGTC_1329 1447-1697 50.6 µM 0.0465559234560844 0.488735637537389 no 1641 0.481433580948949 508 2840515 SGTC_2499 avocadenofuran 51.48 µM 0.0458832616698204 0.48901636027433 no 1642 0.481701647688994 500 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_819 1013-0258 27.7 µM 0.0453675548179612 0.489231584515646 no 1643 0.481907170926265 518 5753198 SGTC_632 0781-2353 4.65 µM 0.0448413830027163 0.489451179418738 no 1644 0.48211686969222 512 6811515 YHR007C ERG11 SGTC_503 tyrphostin 8 294 µM 0.0443716238426811 0.489647233515355 no 1645 0.482304090128352 534 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0418147478761788 0.490714388936402 no 1646 0.48332318909541 518 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1621 st003705 32.4 µM 0.0418055655147605 0.490718221474568 no 1647 0.483326849127185 521 24207032 SGTC_2533 agelasine 13.65 µM 0.0414995381677702 0.490845951795211 no 1648 0.483448830513581 524 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_3186 9110464 49.47 µM 0.0412361665418706 0.490955879135714 no 1649 0.483553810725589 515 17018021 SGTC_3069 9117009 49.47 µM 0.0412241219553427 0.490960906380782 no 1650 0.483558611737991 534 41904981 SGTC_2685 mycophenolic acid 18.85 µM 0.040447780285693 0.491284943729332 no 1651 0.483868069117009 531 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2325 6158266 200 µM 0.0395849224125283 0.491645098826509 no 1652 0.484212024094662 523 3623240 SGTC_313 3474-0040 5.03 µM 0.0395789467642971 0.491647593073847 no 1653 0.484214406166632 529 1043375 YIL048W NEO1 SGTC_2065 5221596 34.26 µM 0.0346120682472461 0.493720881565621 no 1654 0.486194539098527 527 788581 SGTC_1281 0884-0031 11.8 µM 0.0344653162717871 0.493782142046229 no 1655 0.486253049756503 532 1548255 SGTC_557 1315-0110 16.2 µM 0.0344588595428709 0.493784837361308 no 1656 0.486255624089522 530 6833801 SGTC_1351 1496-0003 46.5 µM 0.0336839667602203 0.494108312808949 no 1657 0.486564582194783 530 3891978 SGTC_2265 7929201 200 µM 0.0328977740838319 0.494436509303737 no 1658 0.48687805393018 531 1265108 SGTC_256 clotrimazole 625 nM 0.0325151583577765 0.494596233790823 no 1659 0.487030613900008 527 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2218 6965428 192.983 µM 0.0315735357840948 0.494989321590652 no 1660 0.48740607412465 528 675684 SGTC_2517 totarol 10 µM 0.0309781076531627 0.495237890314041 no 1661 0.487643499427124 523 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2420 aureobasidin a 50 nM 0.0299891119278111 0.495650762660901 no 1662 0.488037868344714 502 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_912 3474-0017 2.18 µM 0.0294218923736216 0.495887559817454 no 1663 0.48826405638603 533 3360550 SGTC_2983 9022671 12.99 µM 0.0285667465603942 0.496244560266341 no 1664 0.4886050668276 534 6405161 SGTC_3105 9121040 49.47 µM 0.0281477849020134 0.496419466640957 no 1665 0.48877214115715 534 41448907 SGTC_533 1222-0222 6.71 µM 0.0280832978633255 0.496446388484238 no 1666 0.488797857597194 522 3982874 SGTC_2885 9057732 51.95 µM 0.0274430893571674 0.496713661548033 no 1667 0.489053165420265 526 6471414 SGTC_3216 9129716 49.47 µM 0.0274367214972805 0.496716319998017 no 1668 0.489055704872591 533 8056934 SGTC_2513 baicalein 25.65 µM 0.0272909039520284 0.49677719585116 no 1669 0.489113855881384 534 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2353 9059630 146.67 µM 0.0272504615388062 0.496794079747752 no 1670 0.489129984071636 522 4779114 SGTC_3264 9137442 49.47 µM 0.0257153238334615 0.497434972928542 no 1671 0.489742200623713 505 17015726 SGTC_1842 st055362 61.2 µM 0.0237969402392536 0.498235873686412 no 1672 0.490507290347494 539 676032 SGTC_966 1300-0360 30.2 µM 0.0231206901044319 0.498518201380054 no 1673 0.490777000890038 536 70588 SGTC_2351 9026858 72.31 µM 0.0230010388055631 0.498568154686526 no 1674 0.490824722161177 536 1409300 SGTC_2117 5521686 200 µM 0.0215834078893838 0.499160003926309 no 1675 0.491390134517937 533 803312 SGTC_1814 st052110 31.539 µM 0.0215622350150743 0.499168843444325 no 1676 0.491398579307422 531 674163 SGTC_2544 sphondin 68.51 µM 0.0204097115639392 0.499650013937639 no 1677 0.491858268378573 539 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3203 9113543 49.47 µM 0.0201268053593179 0.499768125407403 no 1678 0.491971108444748 533 17018012 SGTC_1394 3474-0001 65.7 µM 0.0190160115120895 0.499768125407403 no 1679 0.492414166189891 527 5017666 YIL048W NEO1 SGTC_1708 st033234 31.827 µM 0.0187921661985083 0.49967467146693 no 1680 0.492503451594417 535 674664 SGTC_1884 5633444 25 µM 0.0180692008050565 0.499372838336547 no 1681 0.492791824068056 536 5724239 SGTC_1289 0976-0073 69.1 µM 0.0178375698647581 0.499276134063391 no 1682 0.492884216552025 539 3391136 SGTC_2551 apiole 73.87 µM 0.0176888850675694 0.49921405923818 no 1683 0.492943523846601 540 10659 A possible DNA adduct former. SGTC_3292 9120825 59.784 µM 0.0176475606342987 0.49919680659011 no 1684 0.492960007337251 545 24824900 SGTC_1644 st010134 20.9 µM 0.0169389045057984 0.498900948110179 no 1685 0.493242677952945 545 3818134 SGTC_2223 6903751 107.57 µM 0.0167903598163974 0.498838931916729 no 1686 0.493301930283272 539 5598863 SGTC_1903 st060211 78.3 µM 0.0162155013285488 0.498598933475509 no 1687 0.493531234408927 529 688960 SGTC_1620 st003704 16.5 µM 0.0159201324433171 0.498475619715123 no 1688 0.493649054335086 536 2834414 SGTC_450 aminopyrene 156 nM 0.0149389668382007 0.498065993318294 no 1689 0.49404043617224 544 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1002 4049-0206 172 µM 0.0148922210731942 0.498046477496892 no 1690 0.494059082959992 540 4662749 SGTC_641 4092-0595 30 µM 0.0148297820741177 0.498020409937337 no 1691 0.494083989766187 535 786260 SGTC_2872 9044037 25.97 µM 0.0136192204239721 0.497515016262607 no 1692 0.494566885105848 538 6465195 SGTC_2076 5212012 200 µM 0.0134293683256874 0.497435755832808 no 1693 0.494642618208406 543 604802 SGTC_97 0535-0701 19.132 µM 0.0131345837621647 0.497312687859825 no 1694 0.494760209861298 536 2832013 YGL099W LSG1 SGTC_1830 st055982 50.3 µM 0.013021469647308 0.497265464542433 no 1695 0.494805332005307 540 455313 An antimicrobial agent. SGTC_640 3381-0960 37.1 µM 0.01278400562771 0.497166327272152 no 1696 0.49490005855718 542 1745025 SGTC_2614 arthonioic acid 13.39 µM 0.011953871320266 0.496819761450118 no 1697 0.495231208888904 542 6710684 SGTC_2068 5226020 147 µM 0.0119451095719071 0.49681610359349 no 1698 0.495234704071227 537 1810509 SGTC_334 1502-1024 68.5 µM 0.0115617519825687 0.496656059649297 no 1699 0.495387631057919 544 3296216 SGTC_648 0375-0473 33.3 µM 0.0108276404366252 0.496349584634022 no 1700 0.49568048083483 539 1713139 SGTC_2586 curcumin 80 µM 0.0106898643126509 0.496292066443945 no 1701 0.495735442374858 539 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1954 st077032 68.9 µM 0.0105393461210428 0.496229228837828 no 1702 0.495795487062695 541 698907 SGTC_3214 9129694 49.47 µM 0.00776921049876341 0.495072784345718 no 1703 0.496900564627382 541 17158655 SGTC_3253 9135987 49.47 µM 0.00719164319936516 0.494831673058173 no 1704 0.497130974193107 539 4182430 SGTC_289 k017-0060 526 µM 0.00683681925174448 0.494683549157366 no 1705 0.497272524985017 544 5512909 SGTC_541 4513-1321 94 µM 0.00641383841796452 0.494506973616005 no 1706 0.497441266218666 545 747515 SGTC_2996 9066192 71.4286 µM 0.00510594962925807 0.493960995623781 no 1707 0.497963029662174 546 6472854 SGTC_126 0417-1624 672.48 µM 0.00445508531842296 0.493689296559818 no 1708 0.498222683982985 545 41912 YDL195W SEC31 SGTC_2099 5377090 177.372 µM 0.00420047214951976 0.493583010741788 no 1709 0.498324258989696 545 2243829 SGTC_2294 7971431 200 µM 0.00407515536312712 0.493530698621647 no 1710 0.498374252726213 542 5741572 SGTC_1428 4049-0204 61.7 µM 0.00394430897024387 0.493476078346571 no 1711 0.498426452464901 545 X1428 SGTC_1940 st075990 51.1 µM 0.00273898856343324 0.492972937520617 no 1712 0.498907303022757 546 1084979 SGTC_3041 9091929 49.47 µM 0.0020175677938551 0.492671797794174 no 1713 0.499195107449518 539 25236887 SGTC_2171 5739187 198.077 µM 0.000978948168597636 0.492238258423231 no 1714 0.499609456247604 544 2262761 SGTC_1285 0929-0069 65.5 µM 0.000826781199532926 0.492174741825451 no 1715 0.499670162060443 546 1206237 SGTC_2329 6138490 200 µM 0.000693733295565188 0.492119205952439 no 1716 0.499723240479276 546 720019 SGTC_959 1222-0044 107 µM -2.96908605583427e-05 0.491817242287706 no 1717 0.499988155060384 549 6083612 SGTC_1174 0739-0097 51.1 µM -3.99303237924361e-05 0.491812968278102 no 1718 0.499984070105573 548 728447 SGTC_1096 rimcazole 32.2 µM -0.000438410146771858 0.491646641291348 no 1719 0.499825099661898 549 18528119 A dopamine reuptake inhibitor. SGTC_537 1334-0398 209 µM -0.000642591837119907 0.491561415641724 no 1720 0.499743642964775 549 5846986 SGTC_2963 9082507 9 µM -0.00247681406158392 0.490795827118354 no 1721 0.499011895160414 550 16459611 SGTC_339 3091-4833 71.4 µM -0.00268240539708336 0.490710017130843 no 1722 0.498929876357237 549 3240077 SGTC_2729 fluphenazine 10.66 µM -0.00269919933973824 0.490703007671462 no 1723 0.498923176567712 549 3372 An atypical antipsychotic. SGTC_195 4234-0266 16.654 µM -0.00276132394072816 0.490677078117172 no 1724 0.498898392530102 551 2303354 SGTC_928 2764-0428 58.7 µM -0.00287699062111509 0.490628801284889 no 1725 0.498852248384257 551 662578 SGTC_1167 k781-0610 148 µM -0.00315849706852965 0.490511307007458 no 1726 0.498739944071915 550 4525169 SGTC_1148 3909-7663 27.7 µM -0.00412534007299294 0.490107775441929 no 1727 0.498354232091915 553 4084526 SGTC_27 0485-0001 32.618 µM -0.00422342520410546 0.490066838179026 no 1728 0.498315102126981 550 2054479 SGTC_1663 st014140 55.4 µM -0.00427935135645791 0.490043496628839 no 1729 0.49829279102186 553 4207120 SGTC_1862 st057513 3.81 µM -0.00502068455995606 0.489734094255399 no 1730 0.497997045067317 552 5393163 SGTC_2086 5274770 176.623 µM -0.00528185019919845 0.489625095785468 no 1731 0.497892856434292 551 689278 SGTC_2673 kobusone 100 µM -0.00550733219635848 0.489530990641831 no 1732 0.497802903441244 550 6710676 An epoxy ketone and protein crosslinker. SGTC_347 4534-1311 26.2 µM -0.00754778284648676 0.488679433600171 no 1733 0.496988898889191 551 2862016 SGTC_2163 5671233 125 µM -0.00869718172399844 0.488199768555319 no 1734 0.496530370231044 550 701023 SGTC_1889 st059080 5.18 µM -0.0095988517784693 0.487823497163066 no 1735 0.496170670986777 564 176925 Isolated from Daphnopsis sellowiana. SGTC_1604 st002052 72.4 µM -0.00986097480139098 0.487714113942187 no 1736 0.496066103980426 556 6254834 YHR062C RPP1 SGTC_570 0987-0065 62.6 µM -0.0129156923042574 0.486439458973972 no 1737 0.494847527511283 555 3104428 SGTC_2541 muurolladie-3-one 83.07 µM -0.013057980868336 0.486380088895247 no 1738 0.494790767373828 553 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1951 sophoraflavanone G 9.2 µM -0.0137716805154097 0.486082301418936 no 1739 0.494506068033214 565 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3251 9135047 49.47 µM -0.0148207556896626 0.485644594378251 no 1740 0.494087590376877 557 17682963 SGTC_1780 st038448 24.544 µM -0.0148333081585541 0.485639357198493 no 1741 0.494082583216733 560 728868 YDL195W SEC31 SGTC_2817 7995342 71.43 µM -0.0161077516365074 0.485107643012501 no 1742 0.493574214703208 561 18879975 SGTC_1305 1181-0477 144 µM -0.0175996953517219 0.484485218644107 no 1743 0.492979099857008 553 6252086 SGTC_367 0335-0881 7.1 µM -0.0191459054370766 0.483840194783751 no 1744 0.492362355443847 556 23828853 SGTC_47 0149-0135 24.25 µM -0.0195538827268344 0.483670008149199 no 1745 0.492199626521851 552 5239155 SGTC_1297 1068-0111 14.1 µM -0.0196477795990865 0.483630839740262 no 1746 0.492162174284653 553 767057 SGTC_3174 9107204 49.47 µM -0.0217057763353104 0.482772401449882 no 1747 0.491341328005082 560 3938802 SGTC_251 melphalan 456.522 µM -0.0224403731703885 0.482466003163291 no 1748 0.491048337659271 568 460612 A DNA alkylator. SGTC_282 k297-0036 65.7 µM -0.0232827988196621 0.48211464253793 no 1749 0.490712346274391 562 5061378 SGTC_2357 9067248 200 µM -0.0243430837055889 0.481672436511423 no 1750 0.490289473737166 575 9150235 SGTC_511 blebbistatin 171 µM -0.0250350974228479 0.481383835040203 no 1751 0.490013484339892 564 3476986 A myosin inhibitor. SGTC_569 4130-2812 160 µM -0.0253202094107923 0.481264933088904 no 1752 0.489899777159649 562 743552 SGTC_1451 4152-0210 104 µM -0.0253287209006681 0.481261383517129 no 1753 0.489896382655139 568 659563 SGTC_2286 7945697 125 µM -0.0258789431877045 0.481031925855655 no 1754 0.489676947661764 565 1245733 SGTC_3331 9141060 1.957 µM -0.0260366230606112 0.480966170214432 no 1755 0.489614063683144 567 4906567 YPR165W RHO1 SGTC_1415 3966-0071 78.1 µM -0.026383408520337 0.480821555609099 no 1756 0.489475763813463 564 2893185 SGTC_3172 9105863 49.47 µM -0.0271437983828613 0.480504470783459 no 1757 0.489172520779515 561 2348785 SGTC_668 1682-0499 62.6 µM -0.0279879153396863 0.480152485967188 no 1758 0.488835894767215 560 682214 SGTC_1569 carminic acid 40.6 µM -0.0303745910982325 0.479157360613392 no 1759 0.487884154434711 558 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2259 7964009 200 µM -0.0304988336295999 0.479105561146921 no 1760 0.487834611789263 574 313134 SGTC_1105 epirubicin 18.1 µM -0.031558312410782 0.478663855373426 no 1761 0.487412144346953 573 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_513 4245-1575 41.7 µM -0.032305772743928 0.478352248494538 no 1762 0.487114102812635 562 719745 SGTC_1574 spiramycin 23.7 µM -0.0331915067456592 0.477983014195856 no 1763 0.486760935513747 561 6419898 An antibiotic and protein synthesis inhibitor. SGTC_207 4185-0010 4.486 µM -0.0331988945042264 0.477979934553604 no 1764 0.486757989847891 559 3761753 SGTC_625 k213-0058 121 µM -0.0347927965196182 0.477315535663126 no 1765 0.486122482350064 559 3655420 SGTC_2756 carbadox 75.1 µM -0.0352930653972629 0.477107017509126 no 1766 0.485923026449508 565 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2893 9048488 25.97 µM -0.0357487447030897 0.476917090284286 no 1767 0.485741351358724 558 6467338 SGTC_2176 5809774 33.9695 µM -0.0367298938514374 0.476508164980222 no 1768 0.485350186436248 566 2870539 SGTC_385 1494-0393 12.4 µM -0.0372563376818886 0.476288762838114 no 1769 0.485140309392971 582 3090647 SGTC_2629 bisabolol 100 µM -0.037329457348697 0.476258289856784 no 1770 0.485111159143912 565 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3354 9151612 71.43 µM -0.0374883225475643 0.476192082481384 no 1771 0.485047825430166 561 27261949 SGTC_891 0929-0073 133 µM -0.0397710132472482 0.475240840236429 no 1772 0.48413784300896 584 5603632 SGTC_1579 chlormadinone acetate 49.4 µM -0.0401028193861886 0.475102581690844 no 1773 0.484005577033207 575 45114258 A steroidal progestin. SGTC_1719 st032227 49.2 µM -0.0402818737320003 0.475027973726642 no 1774 0.483934202357765 570 3125804 SGTC_2381 9035592 200 µM -0.040492419130008 0.474940245261674 no 1775 0.483850275372189 587 4749657 SGTC_1817 st052116 64.4 µM -0.040520973128589 0.474928347690847 no 1776 0.483838893316508 564 4361398 SGTC_1368 1852-0141 284 µM -0.0407859710796834 0.474817932283051 no 1777 0.483733261754875 558 2838987 SGTC_2191 5911152 200 µM -0.0415789612242197 0.474487532522244 no 1778 0.48341717262311 574 2875902 SGTC_1527 coumarin 137 µM -0.0417474742583101 0.474417323730735 no 1779 0.483350003970867 568 323 A hepatotoxic, DNA x-linker. SGTC_2858 9025781 8.96 µM -0.0418021704060102 0.474394535453923 no 1780 0.483328202396633 581 4894980 YPL153C RAD53 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0443304692590215 0.473341252759985 no 1781 0.482320492292216 575 75037 A free radical scavenger. SGTC_1793 st048256 72.231 µM -0.0457676787619403 0.472742597639823 no 1782 0.481747710207374 570 672022 SGTC_1943 st076331 65.2 µM -0.0459639354166543 0.47266085365739 no 1783 0.481669497440419 572 24208415 SGTC_3228 9131799 49.47 µM -0.047016352993585 0.472222524916779 no 1784 0.481250097068701 570 17015818 SGTC_455 paf C-16 10 µM -0.0472463848987966 0.472126721784901 no 1785 0.481158429486258 580 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2424 5537928 59.2 µM -0.0474664024939684 0.472035090897441 no 1786 0.481070753532703 570 5382802 SGTC_914 3820-6779 408 µM -0.0477478255244407 0.471917888601848 no 1787 0.480958609143686 573 2893481 SGTC_2240 6690706 185.951 µM -0.0482436018892075 0.47171142198294 no 1788 0.480761050669989 568 805876 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.0484805167438023 0.471612761209042 no 1789 0.480666645783701 588 65057 A dermal irritant. YDR527W RBA50 SGTC_826 1683-5028 118 µM -0.0504128394630016 0.470808130712594 no 1790 0.479896702492491 584 722377 SGTC_370 0180-0345 38.7 µM -0.0504579920595165 0.470789330318958 no 1791 0.47987871210858 571 3989527 SGTC_725 1497-0963 19 µM -0.0505643624285932 0.470745040658093 no 1792 0.479836330571177 564 3549977 SGTC_732 3970-1727 52.7 µM -0.0523992509802794 0.469981101563578 no 1793 0.479105285465045 567 1275699 SGTC_3262 9137218 49.47 µM -0.0530427685354084 0.469713204928835 no 1794 0.478848915646812 565 17650664 SGTC_1068 loratadine 26.9 µM -0.0531927957615365 0.469650750496331 no 1795 0.478789147820083 586 3957 A H1 histamine antagonist. SGTC_2468 5987765 72.9 µM -0.0541872860684809 0.469236775739307 no 1796 0.478392975025102 566 26772094 SGTC_3317 9138495 8.753 µM -0.0543582016847132 0.469165632328184 no 1797 0.478324889906769 565 17020139 SGTC_2844 9010103 25.97 µM -0.0553920363128079 0.468735321028401 no 1798 0.477913070100116 588 2480525 SGTC_614 0462-0418 107 µM -0.0564766567049181 0.468283910518039 no 1799 0.477481045544598 567 5188303 SGTC_1924 st058459 75.1 µM -0.056571346826295 0.468244503158257 no 1800 0.477443329949769 590 688683 SGTC_990 3985-0011 41.3 µM -0.0566861333456766 0.468196732661285 no 1801 0.477397610120294 588 5399565 YGL099W LSG1 SGTC_3086 9117350 49.47 µM -0.0569622176172445 0.468081837048818 no 1802 0.477287646111326 572 2679265 SGTC_2568 diosmetin 100 µM -0.0573065496296524 0.467938543088986 no 1803 0.477150501539636 571 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1529 apigenin 74 µM -0.0578825223366724 0.467698861019612 no 1804 0.476921102466648 572 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_219 mitoxanthrone 164.414 µM -0.0583930767753369 0.467486411531129 no 1805 0.476717764648656 582 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2466 5983409 37.09 µM -0.059067243998167 0.467205894466153 no 1806 0.476449274286738 591 2879657 SGTC_275 trichlorophene 5.69 µM -0.0619577999149364 0.466003337280632 no 1807 0.475298219095074 577 62616 SGTC_1218 1348-1416 30.7 µM -0.0628733371989772 0.465622510748838 no 1808 0.474933683329464 576 6787668 SGTC_1209 2323-2347 50.3 µM -0.0631478216860411 0.465508342406453 no 1809 0.474824397029595 571 5412760 SGTC_938 3126-1755 342 µM -0.0646731053564397 0.464873971978966 no 1810 0.474217138398193 569 1777771 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.064737885618135 0.464847031622713 no 1811 0.47419134885726 584 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1020 4335-0961 93.3 µM -0.0649694716593693 0.464750722579306 no 1812 0.474099153484933 620 669075 SGTC_1128 3448-9350 235 µM -0.0650734842957608 0.464707467804924 no 1813 0.47405774607016 574 619386 SGTC_1898 st060199 18.6 µM -0.0661145014029641 0.464274572695815 no 1814 0.473643332831173 569 688866 SGTC_2460 5552655 174.22 µM -0.0669476622994115 0.463928142665541 no 1815 0.473311684547087 584 5401989 SGTC_79 0052-0007 94.094 µM -0.0695932934084741 0.462828266309848 no 1816 0.472258687542132 571 2801472 SGTC_623 k072-0108 16.9 µM -0.0707146331990719 0.462362173516043 no 1817 0.471812437192606 596 5382803 SGTC_3256 9138902 49.47 µM -0.070841514482267 0.462309437658224 no 1818 0.471761945512641 571 17228773 SGTC_1412 3909-8563 178 µM -0.071206819146755 0.462157609236201 no 1819 0.471616577150758 595 23767530 SGTC_2397 5161689 200 µM -0.0732585978246249 0.461304949274581 no 1820 0.470800168641405 602 2259942 SGTC_1982 st072467 71.9 µM -0.0735777695246447 0.461172326619429 no 1821 0.470673180265967 603 3163533 SGTC_274 sirtinol 40.1 µM -0.0753225393193644 0.460447414229415 no 1822 0.469979044318499 582 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1854 st056233 32.9 µM -0.0755281483378402 0.460361996942737 no 1823 0.469897251179024 607 5393174 SGTC_669 0108-0021 26.2 µM -0.0764716755380486 0.459970045758663 no 1824 0.469521923809682 631 17201 SGTC_2133 5320837 200 µM -0.0765300933487914 0.459945779656647 no 1825 0.469498686571271 593 2841355 SGTC_1722 st034304 3.6505 µM -0.0771955366154471 0.459669372553936 no 1826 0.469233996159046 585 4036148 YLR033W RSC58 SGTC_1161 k007-0610 110 µM -0.0782794286740889 0.45921919495143 no 1827 0.468802890391568 587 5843850 SGTC_1243 0416-0003 5.65 µM -0.079404248890211 0.458752073772086 no 1828 0.468355544594573 597 2141977 SGTC_3000 9075062 71.4286 µM -0.0799708583171971 0.458516790796601 no 1829 0.468130216705655 568 17057871 SGTC_1630 st005209 31.3 µM -0.0804016306994814 0.458337923492918 no 1830 0.46795891499742 571 3367314 SGTC_99 0109-0120 622.8 µM -0.0818899710223683 0.457719993081621 no 1831 0.467367104809199 583 759414 SGTC_703 3875-0075 71.8 µM -0.0829029736441503 0.457299472137736 no 1832 0.466964344778454 590 2850814 SGTC_973 1325-0077 65.9 µM -0.0829066845990655 0.457297931721656 no 1833 0.466962869400651 587 2835149 SGTC_1153 4055-0057 267 µM -0.0835131689267478 0.457046188927553 no 1834 0.466721753340954 581 882706 SGTC_115 0527-0192 112.043 µM -0.0838008502080548 0.45692678264654 no 1835 0.466607386015561 599 4233931 SGTC_2725 haloperidol 53.21 µM -0.0838960685129552 0.456887261766521 no 1836 0.466569532707094 584 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_562 3772-2733 112 µM -0.0856085157208181 0.456176574322982 no 1837 0.465888814374467 594 2876874 YIL048W NEO1 SGTC_2958 9077254 16.72 µM -0.0864253082896278 0.45583764421999 no 1838 0.465564164545054 589 16457351 SGTC_686 1319-0111 510 µM -0.086576378395419 0.455774960818857 no 1839 0.46550412134682 594 4562600 SGTC_1718 roemerine 11.9335 µM -0.0872619507568251 0.45549051066998 no 1840 0.465231648754543 584 235224 An aporphine alkaloid with mutagenic activity. SGTC_1568 digitonin 820 nM -0.0879716838579368 0.455196060049986 no 1841 0.464949590936607 599 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1387 3342-1166 1.8 µM -0.0879935758370215 0.45518697800256 no 1842 0.464940891038505 589 3418228 SGTC_803 4488-1585 147 µM -0.089775595992142 0.454447772898067 no 1843 0.464232770721111 600 747204 SGTC_1159 4092-0538 61.2 µM -0.0912915293787259 0.453819068103047 no 1844 0.463630474230233 585 717301 SGTC_2481 5478948 45.16 µM -0.0943628534215623 0.4525456506737 no 1845 0.462410461386497 589 77792 SGTC_2693 st077581 40.7 µM -0.0958627081725923 0.451923964705557 no 1846 0.461814806349132 614 25238761 SGTC_132 0417-1715 25.805 µM -0.0960506771611073 0.451846060319766 no 1847 0.461740162015417 593 6769098 SGTC_2249 haloperidol 116.36 µM -0.0972465349321383 0.451350476551939 no 1848 0.461265306804647 591 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_776 4476-4378 112 µM -0.0973727100506562 0.451298191848479 no 1849 0.461215207974555 596 2892008 SGTC_713 1488-1073 324 µM -0.098524124984761 0.45082110532192 no 1850 0.460758058091689 603 3312542 SGTC_1141 3253-0389 52.6 µM -0.0993250089501548 0.450489302468082 no 1851 0.460440111162423 583 5402031 SGTC_3239 9133757 49.47 µM -0.0999589707791904 0.450226679275354 no 1852 0.460188449410099 590 17036923 SGTC_2991 9074669 71.4286 µM -0.100544144749106 0.449984286140051 no 1853 0.459956168965923 599 17333109 SGTC_3301 9125354 19.7965 µM -0.100634795117816 0.449946738243444 no 1854 0.459920187198478 590 41905162 SGTC_1203 3992-3522 103 µM -0.101160755008448 0.449728891527684 no 1855 0.45971142490954 626 5322312 SGTC_1701 st028638 40.4 µM -0.10173201531256 0.449492299051044 no 1856 0.459484694713091 600 3490878 SGTC_2131 toluylene red 5.2905 µM -0.102313665860565 0.449251421811286 no 1857 0.459253854221996 589 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1371 2421-0008 32.7 µM -0.102461932325967 0.449190023641367 no 1858 0.4591950136903 608 2827552 SGTC_3060 1327-0027 12.5 µM -0.102651069518667 0.449111702386365 no 1859 0.459119954636597 579 16000455 YPR107C YTH1 SGTC_1383 3049-0032 20.7 µM -0.102988778325817 0.448971862917244 no 1860 0.458985938595754 628 712864 SGTC_3273 9137859 49.47 µM -0.103813382116393 0.448630435191791 no 1861 0.458658723230254 587 2377234 SGTC_2156 5649887 115 µM -0.105493099020465 0.447935065273652 no 1862 0.457992272809852 597 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_371 0195-0006 7.36 µM -0.105691919813508 0.447852767903675 no 1863 0.457913395748284 589 3928593 SGTC_3242 9133940 49.47 µM -0.106211662590905 0.44763764274979 no 1864 0.457707208939839 621 17248444 SGTC_797 k781-0471 270 µM -0.106607294738573 0.44747389817027 no 1865 0.457550265602539 594 23738129 SGTC_153 4077-0274 519.67 µM -0.106884926542579 0.447358997019688 no 1866 0.457440135778616 585 3121976 SGTC_3061 glucosamine 200 µM -0.107621656960819 0.447054114010353 no 1867 0.457147908499443 587 91431 and experimental redox chemotherapeutic SGTC_3073 9114972 49.47 µM -0.107794764151943 0.446982481157097 no 1868 0.457079248145657 591 41905075 SGTC_3319 9138450 16.7555 µM -0.108127857775894 0.446844649771697 no 1869 0.456947135195016 612 2029690 SGTC_321 4534-3890 65.3 µM -0.108401645889412 0.446731363322656 no 1870 0.456838547799827 607 699746 SGTC_2975 9084847 53.72 µM -0.108666706322497 0.446621692303517 no 1871 0.45673342496945 582 27211724 SGTC_2829 7992743 58.44 µM -0.109641213914315 0.446218516620016 no 1872 0.456346961849237 585 16462845 SGTC_292 k038-0015 474 µM -0.110953400742545 0.445675723354236 no 1873 0.455826649654012 611 46368540 SGTC_576 1073-0113 22.7 µM -0.11104405858737 0.445638225988578 no 1874 0.455790704525034 611 5439563 SGTC_1526 st051518 75 µM -0.111796227215452 0.445327137200387 no 1875 0.455492489508692 616 673993 SGTC_2655 perillic acid 100 µM -0.111996446692031 0.445244334261104 no 1876 0.455413111987656 602 5702197 An apoptosis inducer. SGTC_2790 5423970 71.43 µM -0.112731254413092 0.444940467044508 no 1877 0.455121810873679 608 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.113425509959936 0.444653399207671 no 1878 0.454846608095109 614 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1480 1070-0044 41.2 µM -0.11352300171082 0.444613089648914 no 1879 0.454807964114141 589 3124987 SGTC_1555 citronellol 128 µM -0.115163808010393 0.443934757723162 no 1880 0.454157642393646 597 8842 A terpine precursor. SGTC_1802 st050112 57.9 µM -0.115505809242625 0.443793390318657 no 1881 0.454022108093889 590 4662563 SGTC_1687 st020778 55.3625 µM -0.115580395385099 0.443762560825364 no 1882 0.453992550488198 586 4259299 SGTC_693 4161-2696 114 µM -0.115762807261513 0.443687163994975 no 1883 0.453920263893976 599 805759 SGTC_3005 9076496 71.4286 µM -0.116193491645496 0.443509156061141 no 1884 0.453749597365321 603 21368410 SGTC_487 nimodipine 119 µM -0.116561745793991 0.443356960463221 no 1885 0.453603676726112 588 4497 L-type voltage-gated calcium channels inhibitor SGTC_1314 1222-0010 41.1 µM -0.117385853562774 0.443016395625101 no 1886 0.453277146894411 599 3526027 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.118154387067849 0.44269883493357 no 1887 0.452972665281149 616 23847180 SGTC_268 camptothecin 39.6153 µM -0.118269659582801 0.442651207102996 no 1888 0.452926998394909 604 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_588 3970-1144 52.9 µM -0.118468087145538 0.44256922354838 no 1889 0.452848389883566 604 1888707 SGTC_2135 5326629 150.42 µM -0.118601025390625 0.442514299339319 no 1890 0.452795726471655 603 5020077 SGTC_2107 5363541 170.161 µM -0.120542681215374 0.441712219398801 no 1891 0.452026635697899 606 244052 SGTC_2247 cerulenin 830 nM -0.121420617603978 0.441349630302018 no 1892 0.451678943605528 586 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_319 1348-1596 45.5 µM -0.121893682878444 0.441154273964429 no 1893 0.451491609327051 629 5380505 SGTC_746 1095-0025 46.6 µM -0.12237917472273 0.440953800855711 no 1894 0.451299365347435 600 6749286 SGTC_1991 st073000 8.92 µM -0.123232621310483 0.440601425688811 no 1895 0.45096144718181 626 4301969 YIL048W NEO1 SGTC_1054 3429-0080 167 µM -0.123647790237967 0.440430025714942 no 1896 0.45079707582988 640 1162877 SGTC_2555 cholic acid 100 µM -0.123823512435043 0.440357483231417 no 1897 0.450727507423558 598 6708657 Influences liver metabolism. SGTC_2767 sibutramine 71.45 µM -0.124234665601657 0.440187756827138 no 1898 0.450564737829794 640 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_883 0850-0245 24.6 µM -0.124273605964062 0.44017168258964 no 1899 0.450549322333933 597 6823229 YPR165W RHO1 SGTC_162 k030-0015 37.8 µM -0.12522915168252 0.439777272722548 no 1900 0.450171069597802 615 1809920 YMR134W ERG29 SGTC_3250 9135583 49.47 µM -0.126054749343926 0.43943654816318 no 1901 0.449844293228471 595 7699353 SGTC_2610 ononetin 44.17 µM -0.127806343029508 0.438713813449261 no 1902 0.449151115111495 630 259632 SGTC_16 erodoxin 22.806 µM -0.127916437439338 0.438668393587945 no 1903 0.449107551357788 613 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2670 beta-carotene 100 µM -0.129144981987105 0.438161607860859 no 1904 0.448621464763052 602 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2438 5259590 200 µM -0.129453858125856 0.438034209581069 no 1905 0.448499266767456 610 1201127 SGTC_2831 7999036 19.48 µM -0.131795464475649 0.437068606297374 no 1906 0.447573037041313 641 2988270 SGTC_1184 1269-1718 139 µM -0.132355241812103 0.43683782738364 no 1907 0.447351657503168 597 5403821 SGTC_270 tamoxifen 5.46 µM -0.132709059638346 0.436691970298529 no 1908 0.447211738844853 605 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1065 prochlorperazine maleate 2.48 µM -0.132951719567967 0.436591941675198 no 1909 0.447115781813156 606 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_48 0382-0018 55 µM -0.135577639496333 0.435509752671887 no 1910 0.44607759165346 602 762596 SGTC_1635 st007035 42.4 µM -0.13685544354335 0.434983320674835 no 1911 0.445572529134127 597 3716403 SGTC_1063 disulfiram 1.84 µM -0.137548832778351 0.434697705106793 no 1912 0.445298498270241 589 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2712 st079126 47.7 µM -0.138348978790434 0.434368157465603 no 1913 0.444982309086732 626 3152970 SGTC_1583 clindamycin 39.6 µM -0.138559525846667 0.434281449254546 no 1914 0.444899114203345 627 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1449 4112-4002 201 µM -0.13921219237313 0.434012685994566 no 1915 0.444641237099934 604 2059539 SGTC_603 3794-0023 45.9 µM -0.140751440769984 0.433378955873318 no 1916 0.444033152852148 640 3802260 SGTC_1339 1486-1321 22.7 µM -0.143303605855044 0.432328571905165 no 1917 0.443025204083024 620 3469382 SGTC_700 3453-2283 142 µM -0.143415856732664 0.432282384200954 no 1918 0.442980880281863 607 565664 SGTC_1518 st038567 90.8 µM -0.145413796266363 0.431460450351108 no 1919 0.442192086296493 607 77966 SGTC_1301 naphtanilide LB 4.81 µM -0.145715819400507 0.431336226553202 no 1920 0.442072866296706 631 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2254 7938975 95.19 µM -0.147613026474126 0.430556050517199 no 1921 0.441324087045027 657 2969277 SGTC_1076 itraconazole 331 nM -0.148282911115081 0.430280642818787 no 1922 0.441059750609807 609 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1397 3532-0190 20.1 µM -0.148365889283934 0.430246530606618 no 1923 0.441027009255061 607 5322280 SGTC_2032 5185112 25.99 µM -0.148865948519131 0.43004096796705 no 1924 0.440829705455086 599 5718189 SGTC_1453 4237-0541 195 µM -0.149709548514402 0.429694226770505 no 1925 0.440496887231814 603 739892 SGTC_1215 3852-0577 11.2 µM -0.149946736721156 0.42959674609977 no 1926 0.440403318976283 600 2884876 SGTC_547 1120-0019 610 nM -0.15048289713607 0.42937640831989 no 1927 0.440191821596997 620 3676939 SGTC_2301 7769476 200 µM -0.150772906217603 0.429257236814508 no 1928 0.440077429806027 627 977820 SGTC_887 0885-0007 9.62 µM -0.153325589926809 0.428208558780224 no 1929 0.439070760710616 624 5719458 SGTC_1914 st062367 72.6 µM -0.153459329833194 0.428153630470774 no 1930 0.439018030225192 631 978205 SGTC_1737 st035557 69.7 µM -0.154357062535497 0.427784958807799 no 1931 0.438664103488693 606 5716916 SGTC_3008 9078912 71.4286 µM -0.156171136104994 0.427040166390972 no 1932 0.437949063800534 643 16648731 SGTC_3139 9095020 49.47 µM -0.157680100134424 0.426420838789805 no 1933 0.437354441050696 601 25236292 SGTC_2346 9031566 143.75 µM -0.158326253562602 0.426155691920575 no 1934 0.437099860847046 637 4771086 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.158788177208798 0.425966163570094 no 1935 0.436917881924114 622 229346 A bile salt which induces apoptosis. SGTC_1702 st027038 51 µM -0.159236362553096 0.425782288421412 no 1936 0.436741328084625 617 5521182 SGTC_1947 st076332 61.6 µM -0.160270369710674 0.425358132205328 no 1937 0.436334049338206 638 24208416 SGTC_76 0433-0009 400.328 µM -0.160934612813959 0.425085701055986 no 1938 0.436072450266602 690 2841569 SGTC_353 1988-1175 58.3 µM -0.161054561701196 0.425036509302573 no 1939 0.436025213735843 626 2788357 SGTC_2439 5492030 7.2 µM -0.161060231397387 0.425034184155264 no 1940 0.436022981000916 631 5722370 SGTC_3162 9099653 49.47 µM -0.161181463445876 0.424984467411547 no 1941 0.435975240125036 608 25237511 SGTC_2738 aclarubicin 5.55 µM -0.161288267610384 0.424940668469783 no 1942 0.435933181686509 610 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_998 3996-0085 177 µM -0.161763054061584 0.424745976196404 no 1943 0.435746224187197 605 715391 SGTC_856 0433-0016 11.3 µM -0.162573797832675 0.424413562775788 no 1944 0.435427009395884 628 3911780 SGTC_2441 5730946 39.09 µM -0.162825950371021 0.424310188547851 no 1945 0.435327737743583 611 1774275 SGTC_549 1661-1316 519 µM -0.164802182957262 0.423500179201731 no 1946 0.434549842893287 649 2857282 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.166535104396663 0.422790162954032 no 1947 0.433867929778603 677 6710655 SGTC_2290 7904846 200 µM -0.167549966917146 0.422374467601745 no 1948 0.433468667614018 632 2962154 SGTC_2320 7373003 200 µM -0.167615803111026 0.422347503580533 no 1949 0.433442769006564 643 5415828 SGTC_335 4077-0256 27.6 µM -0.167959950997674 0.422206559515824 no 1950 0.433307392945372 649 3121989 SGTC_2962 9082311 13.18 µM -0.168162717029913 0.422123522352767 no 1951 0.433227635354305 616 16459453 SGTC_2087 5276107 200 µM -0.169595471216438 0.421536876763082 no 1952 0.432664142199969 609 144405 SGTC_1171 0368-0077 21.4 µM -0.170002053719296 0.421370431970457 no 1953 0.432504260763625 610 3239779 SGTC_2770 toltrazuril 17.5 µM -0.171386531457506 0.420803766668457 no 1954 0.431959922216982 615 68591 Kills coccidiodes. SGTC_1736 st036774 51 µM -0.172090307032911 0.420515774873874 no 1955 0.431683266474913 677 1272247 SGTC_2886 9058944 51.95 µM -0.172339967128855 0.420413621754349 no 1956 0.431585132580659 610 4949929 SGTC_2109 5483026 200 µM -0.172534275164581 0.420334120679249 no 1957 0.431508758842345 615 759335 SGTC_31 0508-1974 57.237 µM -0.172680954016844 0.420274109222868 no 1958 0.431451107686837 608 6810525 SGTC_1491 4138-0063 26.5 µM -0.173364427856736 0.419994500593547 no 1959 0.431182492075427 632 23883227 SGTC_2793 7325131 81.82 µM -0.173586724578243 0.419903567868627 no 1960 0.431095132936981 641 4176441 SGTC_2393 9031399 185.94 µM -0.173934435185234 0.419761341900751 no 1961 0.430958494862633 649 1526623 YDL150W RPC53 SGTC_3163 9099914 49.47 µM -0.173995831314035 0.419736229795079 no 1962 0.430934369195086 625 16268368 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.174235095903124 0.419638369453902 no 1963 0.43084035240596 606 804 An inhibitor of viral and cellular DNA polymerases. SGTC_838 0109-0203 71.4 µM -0.17423566619608 0.419638136207338 no 1964 0.430840128319341 620 759422 SGTC_1047 2043-3044 82 µM -0.174923343236723 0.419356900788688 no 1965 0.430569933904186 678 669592 SGTC_1362 1611-0397 101 µM -0.176729454348657 0.418618462189187 no 1966 0.429860451901788 615 27816 SGTC_273 hydroxyurea 18.1 mM -0.177048595301124 0.418488009361393 no 1967 0.429735109468063 617 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1126 isoteolin 1.0172 µM -0.177424810057137 0.418334238421322 no 1968 0.429587360425427 607 133323 SGTC_2021 4019055 173 µM -0.17774604481338 0.418202949433338 no 1969 0.42946121122279 639 44827708 YER133W GLC7 SGTC_1144 3486-0183 12.5 µM -0.177873056483755 0.418151042141211 no 1970 0.429411335601956 669 6744069 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.179151552510864 0.417628624292345 no 1971 0.428909351842897 627 688761 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.179910557369248 0.41731854913484 no 1972 0.428611393430179 633 91467 include heat shock SGTC_73 0327-0325 16.231 µM -0.180288509364289 0.417164164115353 no 1973 0.428463038032567 636 53298 SGTC_2815 7968870 71.43 µM -0.181350362604044 0.416730489001228 no 1974 0.428046288838796 659 2977326 YHR190W ERG9 SGTC_1618 st003135 44.5 µM -0.181471552591494 0.416680999815855 no 1975 0.427998730080807 629 1270615 SGTC_2069 5228469 200 µM -0.182197809078403 0.416384453159141 no 1976 0.427713746160086 644 2835210 SGTC_2180 6301957 200 µM -0.183003041278823 0.416055714600934 no 1977 0.427397816161181 648 845462 SGTC_1036 k216-0215 33.5 µM -0.184319709356239 0.415518307362203 no 1978 0.426881326491734 619 622330 SGTC_2561 acetosyringone 100 µM -0.184429898529714 0.415473340034321 no 1979 0.426838108232228 624 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_3222 9128301 49.47 µM -0.184632196195606 0.415390786843287 no 1980 0.426758765582022 628 4911358 SGTC_2373 9071805 200 µM -0.184996715490318 0.415242044033328 no 1981 0.426615805884548 680 10149009 SGTC_1472 k841-0093 193 µM -0.18734929087597 0.414282364124793 no 1982 0.425693389283483 649 X1472 SGTC_3350 9150499 3.57 µM -0.18775020764479 0.414118870055998 no 1983 0.425536235026298 627 4910996 YPR165W RHO1 SGTC_465 cgp-37157 41 µM -0.188062821161483 0.413991396424616 no 1984 0.425413702723636 634 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_890 0929-0006 47.2 µM -0.188524996322477 0.413802953020656 no 1985 0.425232561292116 638 1378169 SGTC_1897 st060201 15 µM -0.189973020848021 0.413212676405862 no 1986 0.424665135885139 627 611878 SGTC_1749 st037932 54.2 µM -0.19019223722733 0.413123331511645 no 1987 0.424579246947629 653 594497 SGTC_571 k831-0106 44.2 µM -0.192620342790454 0.412134022910649 no 1988 0.423628156015984 650 4783639 SGTC_2297 7971671 152.32 µM -0.193539468745277 0.411759679028921 no 1989 0.423268249371387 645 909016 SGTC_2674 ligustilide 100 µM -0.194644832510475 0.411309590129604 no 1990 0.42283550149128 620 5319022 A signalling regulator. SGTC_2719 novobiocin 32.65 µM -0.196301476745134 0.410635246115446 no 1991 0.422187102801213 642 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2451 5856223 45.7 µM -0.197613232666166 0.410101477570028 no 1992 0.421673840401665 618 2179896 SGTC_2878 9043973 25.97 µM -0.199528551256817 0.409322411768603 no 1993 0.420924655832414 630 6465167 SGTC_2617 dihydrotanshinone i 20.83 µM -0.200142230083893 0.409072870291549 no 1994 0.420684673316963 612 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2470 5664817 21.68 µM -0.201323486676023 0.408592637312717 no 1995 0.420222819406382 634 2859561 SGTC_865 0488-0499 301 µM -0.203321635789171 0.407780614166962 no 1996 0.419441822893036 643 9634651 SGTC_953 1188-0045 9.7 µM -0.203496799964078 0.407709448436498 no 1997 0.419373373308161 647 6144426 SGTC_2680 butyl paraben 22.24 µM -0.20381947106957 0.407578361538776 no 1998 0.419247288255573 644 7184 An antifungal and steroid mimetic. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.205630482109001 0.406842820843155 no 1999 0.418539782523414 665 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1405 3909-7894 12 µM -0.206138610869034 0.406636503651238 no 2000 0.41834131963682 629 7104060 SGTC_299 1273-0059 1.44 µM -0.208320175113635 0.405751011077283 no 2001 0.41748948986527 647 2848077 SGTC_3091 9116372 49.47 µM -0.208499677471704 0.405678172830263 no 2002 0.417419417222239 640 17169793 SGTC_2082 5219693 150 µM -0.209019660024775 0.405467193387086 no 2003 0.417216445551641 653 2834649 SGTC_772 k072-0172 35.3 µM -0.209242819360556 0.405376656397746 no 2004 0.417129343577079 630 5861980 SGTC_2125 5246583 200 µM -0.213026841967214 0.403842231819271 no 2005 0.415653013155681 658 835267 SGTC_1109 tnp00067 928.257 nM -0.213433575319359 0.403677388669006 no 2006 0.41549439723043 625 676295 SGTC_1509 1326-1131 80 µM -0.213645355387947 0.403591564038783 no 2007 0.415411813702802 615 768313 SGTC_1193 1488-0126 41.5 µM -0.21382260928608 0.403519734831132 no 2008 0.415342696509646 619 1384710 SGTC_1432 4049-0298 68.4 µM -0.214181729441446 0.403374217311771 no 2009 0.415202671643169 652 741646 SGTC_1101 ebselen 5.29 µM -0.215542616365631 0.402822899790129 no 2010 0.414672144865626 654 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3044 9093193 49.47 µM -0.215783550225341 0.40272531364348 no 2011 0.414578235639469 688 25236277 SGTC_3328 9140624 29.0385 µM -0.216236650922854 0.402541809360337 no 2012 0.414401642989445 646 4904392 SGTC_2571 chrysanthemic acid 100 µM -0.216445805742663 0.402457109591231 no 2013 0.414320132277714 705 2743 An insecticide. SGTC_1647 st011722 22.4 µM -0.216447750168896 0.402456322193832 no 2014 0.414319374523498 655 2854783 SGTC_235 0330-0087 5 mM -0.21658819715043 0.402399449091299 no 2015 0.414264642361274 643 46494818 YHR062C RPP1 SGTC_2022 5136654 200 µM -0.216754374642286 0.402332159252284 no 2016 0.414199885174452 670 1713771 SGTC_1021 4476-0760 85.3 µM -0.217275940696913 0.402120981610074 no 2017 0.413996652887443 639 746768 SGTC_3133 9127736 49.47 µM -0.217590359342478 0.401993689983057 no 2018 0.413874148329188 661 27243420 SGTC_1969 st069479 40.1 µM -0.217652589667415 0.401968497418614 no 2019 0.41384990299162 647 3895485 SGTC_626 0214-0009 33 µM -0.221060363933553 0.400589560296265 no 2020 0.412522715885748 666 3437874 SGTC_3110 9122132 49.47 µM -0.222221497641959 0.400119995832749 no 2021 0.412070729886639 618 918317 SGTC_2355 9061122 103.12 µM -0.223327465364353 0.399672874809937 no 2022 0.411640326369279 670 5302957 SGTC_186 3455-3465 67.277 µM -0.224217319247844 0.399313219824765 no 2023 0.411294103857124 637 755278 SGTC_2948 9070189 9.45 µM -0.225060806473574 0.398972383865153 no 2024 0.410965985351137 650 6473636 YDL196W YDL196W SGTC_1191 1487-1166 10.6 µM -0.22547367848852 0.398805578775843 no 2025 0.410805399861167 651 3955771 SGTC_1085 doxorubicin 7.67 µM -0.226054390561508 0.398570995637783 no 2026 0.410579558724638 655 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1062 mesoridazine 14.2 µM -0.226784520635641 0.39827610594785 no 2027 0.41029565043483 635 4078 A neuroleptic. SGTC_409 arachidonic acid 100 µM -0.228502547163211 0.397582447628049 no 2028 0.409627788074894 656 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_993 3909-8757 62.7 µM -0.228833664193951 0.397448795282284 no 2029 0.409499100342423 635 4288324 YLR208W SEC13 SGTC_2020 4017018 200 µM -0.229114164545677 0.397335583311992 no 2030 0.40939009227246 676 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1485 3909-9022 254 µM -0.229394810673653 0.397222321160561 no 2031 0.409281034561735 645 714516 SGTC_1104 tacrolimus 29.8 µM -0.229723283939819 0.397089768113792 no 2032 0.409153400377378 646 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1804 st050076 49.1 µM -0.230070645537819 0.396949605747243 no 2033 0.409018437270141 632 3895976 SGTC_1437 4092-1038 11.6 µM -0.230280221820598 0.396865046970347 no 2034 0.408937014180338 653 3977136 SGTC_1366 1683-0113 21.9 µM -0.230302282717941 0.396856146233255 no 2035 0.408928443465621 660 708623 SGTC_2384 9036245 200 µM -0.230392755177588 0.396819644582181 no 2036 0.408893295140493 629 6462766 SGTC_1197 1601-0112 267 µM -0.23248178012038 0.395977067118651 no 2037 0.408081918475171 655 7350313 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.232531402435844 0.395957058579319 no 2038 0.408062649959523 634 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1258 0671-0043 57.1 µM -0.233323873004603 0.395637558502202 no 2039 0.407754961071796 693 4298767 SGTC_3265 9137266 49.47 µM -0.234313511840913 0.395238664644423 no 2040 0.407370798471008 651 17224265 SGTC_2608 thymoquinone 42.66 µM -0.235027967128002 0.394950757247978 no 2041 0.407093513241775 633 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1870 st057514 26.5 µM -0.235766384163751 0.39465325414081 no 2042 0.406806977212674 629 5393161 SGTC_518 1021-0119 62.6 µM -0.236760064888799 0.394253004037667 no 2043 0.406421467177127 671 1097762 SGTC_2416 tofa 880 nM -0.237249339808185 0.394055967303705 no 2044 0.406231680558396 652 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1396 3511-0007 98.6 µM -0.238895514627005 0.393393232794633 no 2045 0.405593301843754 672 X1396 SGTC_675 1309-0189 238 µM -0.239934600649879 0.392975065361082 no 2046 0.405190478375856 639 4246530 SGTC_1956 st077085 54 µM -0.240462470477009 0.392762677885593 no 2047 0.404985877015696 652 24208685 SGTC_1331 1472-0049 76.2 µM -0.240544920436602 0.392729507173806 no 2048 0.404953921908692 646 24051409 SGTC_733 4069-0007 56.1 µM -0.240917016317527 0.392579817763248 no 2049 0.404809716702628 645 5717425 YNL287W SEC21 SGTC_2828 7998861 71.43 µM -0.241000097093586 0.392546397599479 no 2050 0.404777520635907 643 2988188 SGTC_1481 3346-2004 36 µM -0.242116833086758 0.392097255155824 no 2051 0.404344817631977 666 2770522 SGTC_279 1273-0055 2.93 µM -0.242201349911762 0.392063268995895 no 2052 0.404312074553985 653 2847562 SGTC_457 grayanotoxin iii 135 µM -0.242399625869781 0.39198354090356 no 2053 0.404235262122929 660 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1664 st014217 9.02 µM -0.243602112168054 0.391500110371523 no 2054 0.403769496148828 663 3982782 SGTC_3135 9127742 49.47 µM -0.24368670319378 0.391466108894011 no 2055 0.403736736145849 640 3643468 SGTC_841 0251-0215 91.2 µM -0.244413782092296 0.391173892765211 no 2056 0.403455184419459 675 3888614 SGTC_2583 asiatic acid 100 µM -0.244909972646418 0.390974506902668 no 2057 0.403263069875998 670 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1277 0873-0036 22 µM -0.244981071044861 0.390945939548108 no 2058 0.40323554398305 653 5965735 SGTC_3185 9108267 49.47 µM -0.246060477052127 0.390512306308535 no 2059 0.402817708668119 666 4910486 SGTC_3161 9100388 49.47 µM -0.246113062279304 0.390491184550127 no 2060 0.402797355891501 649 25236368 SGTC_2017 5132927 60.65 µM -0.246967263745516 0.390148125185506 no 2061 0.402466779594095 667 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_133 0724-0033 378.92 µM -0.247963454931624 0.389748148799691 no 2062 0.402081341316945 644 280309 SGTC_718 1130-0073 349 µM -0.248488111567989 0.389537543099098 no 2063 0.401878383642111 678 6740020 SGTC_1306 1185-0270 9.02 µM -0.24916214359485 0.38926702329966 no 2064 0.401617680570155 654 1548076 SGTC_2899 9053889 58.44 µM -0.249239446567084 0.389236001518125 no 2065 0.401587784012238 658 6470052 SGTC_751 0833-0568 350 µM -0.249349878436175 0.389191686292614 no 2066 0.401545076009799 661 6954252 SGTC_3269 9137823 49.47 µM -0.250056818606216 0.388908032307209 no 2067 0.40127170452966 642 17682936 SGTC_2730 imipramine 71.33 µM -0.25080334987581 0.38860855699168 no 2068 0.400983075757831 663 3696 A tricyclic antidepressant. SGTC_1988 st071872 53.4 µM -0.252148240816065 0.388069213399348 no 2069 0.400463241741212 648 16414116 SGTC_2237 6667747 47.222 µM -0.25258070187374 0.387895828712528 no 2070 0.400296122123697 675 729940 YDL015C TSC13 SGTC_2050 5263056 171 µM -0.253620798090625 0.387478919133186 no 2071 0.39989426366498 672 763468 YGL055W OLE1 SGTC_741 4582-0002 126 µM -0.253631168571482 0.387474762907822 no 2072 0.399890257390355 629 2912688 SGTC_613 3914-0030 117 µM -0.253716299139806 0.387440645225459 no 2073 0.399857370554203 645 1145395 SGTC_3184 9108758 49.47 µM -0.254012538738142 0.387321928391173 no 2074 0.399742935611845 654 902885 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.254110162164904 0.387282808501093 no 2075 0.399705226363656 672 521171 SGTC_1467 k284-1082 293 µM -0.254260464622803 0.387222581183195 no 2076 0.399647170481679 685 3334705 SGTC_612 0302-0167 22.4 µM -0.254964711376375 0.386940420428189 no 2077 0.399375177446647 654 235821 SGTC_2330 7979373 200 µM -0.258052180730702 0.385704113918891 no 2078 0.398183318080247 649 1863007 SGTC_1798 st045719 60.953 µM -0.258218112000872 0.385637703276833 no 2079 0.398119290223116 633 3980186 SGTC_122 0236-0016 402.397 µM -0.258782314564677 0.385411917676865 no 2080 0.397901602055063 661 6808838 SGTC_2789 5281112 71.43 µM -0.258811925173308 0.385400069016911 no 2081 0.397890178171777 669 765948 SGTC_2119 5528445 120.635 µM -0.258909747314577 0.385360926330403 no 2082 0.39785243864711 663 791935 SGTC_1251 0490-5699 265 µM -0.259379896549908 0.385172816467165 no 2083 0.397671069651627 668 3883818 SGTC_1190 1486-1332 13 µM -0.259763593613762 0.38501931671706 no 2084 0.397523067611149 669 4150046 SGTC_1119 parthenolide 318.541 nM -0.261881040460071 0.384172547173999 no 2085 0.396706578581684 707 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1649 st011737 51.3 µM -0.262065249907038 0.384098907662433 no 2086 0.396635568638644 650 1761035 SGTC_2274 7947094 46.08 µM -0.262805441194262 0.383803051229864 no 2087 0.396350270726728 650 2971028 SGTC_575 k072-0246 11.9 µM -0.263034138017464 0.383711654184876 no 2088 0.396262133475973 653 6796779 SGTC_1949 st076024 69.1 µM -0.264051885179813 0.383304997349336 no 2089 0.395869969222351 642 2921930 SGTC_622 1348-1566 26.3 µM -0.264596929888607 0.383087269013519 no 2090 0.395659992729665 678 7340407 SGTC_1198 1612-1005 86.7 µM -0.264830291300947 0.382994059705265 no 2091 0.395570100348087 656 6998509 SGTC_1075 aripiprazole 15.2 µM -0.265626801376229 0.382675968387974 no 2092 0.395263321191204 660 60795 An atypical antipschotic. YIL048W NEO1 SGTC_775 4577-0580 57.3 µM -0.267076297943186 0.382097305958181 no 2093 0.394705208224385 705 2006902 SGTC_123 0083-0120 66.675 µM -0.26761294952114 0.381883132694775 no 2094 0.394498631077554 665 16001701 SGTC_3090 9117696 49.47 µM -0.267754922842994 0.381826478344813 no 2095 0.39444398522685 695 7923821 SGTC_32 0928-0142 34.1 µM -0.268107241143039 0.381685896921518 no 2096 0.394308386097042 666 2244242 SGTC_2661 dactinomycin 12.96 µM -0.268331194783752 0.381596543447542 no 2097 0.394222198200217 657 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2830 7992007 71.43 µM -0.268820197042367 0.381401462277433 no 2098 0.394034025132252 640 1952075 SGTC_1164 k060-0068 93.7 µM -0.269132012171945 0.381277083363829 no 2099 0.393914048394803 657 5963676 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.269264616912042 0.381224192809639 no 2100 0.393863029276851 655 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1001 4048-4355 44.4 µM -0.270084339738721 0.38089728850968 no 2101 0.393547684823031 693 21824233 SGTC_1420 4'-methoxyflavone 42 µM -0.271295623830024 0.38041438578827 no 2102 0.393081835991619 679 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2253 7938677 135.83 µM -0.272089033681601 0.380098177954395 no 2103 0.392776780711443 667 2301972 SGTC_1958 st076513 41.9 µM -0.272525161384866 0.379924396485542 no 2104 0.392609123585039 694 732122 YGL099W LSG1 SGTC_2639 lactacystin 53 µM -0.273122659268964 0.379686354070202 no 2105 0.392379464550024 674 3870 A proteasome inhibitor. SGTC_828 2074-0507 139 µM -0.273311277558284 0.379611218240828 no 2106 0.392306973504144 658 X828 SGTC_1265 0819-1001 68.8 µM -0.27374374401649 0.379438963000987 no 2107 0.392140779205093 668 3106768 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.275436602935711 0.378764912677891 no 2108 0.391490413048876 664 641818 YHR062C RPP1 SGTC_1938 st074717 56.4 µM -0.276941164909276 0.378166146358334 no 2109 0.390912641632402 652 17250979 SGTC_26 0302-0163 425.158 µM -0.277648243722375 0.377884853121324 no 2110 0.390641197211792 702 3100915 SGTC_124 0136-0217 7.121 µM -0.278191784612944 0.377668663267843 no 2111 0.390432570491529 694 3976905 SGTC_1324 1418-0026 34.4 µM -0.280499409370219 0.376751247942843 no 2112 0.389547189269284 692 1372513 SGTC_1375 2910-0797 186 µM -0.281070572088392 0.376524284658322 no 2113 0.389328135879657 673 742508 SGTC_2846 9008642 19.48 µM -0.281463523831189 0.376368161956664 no 2114 0.389177450709078 738 2992898 SGTC_129 0088-0017 176.636 µM -0.282813287117775 0.375832044978983 no 2115 0.388659984167138 701 182446 SGTC_771 0250-0039 27.3 µM -0.282840816320657 0.375821113052949 no 2116 0.388649432189878 679 3005115 SGTC_843 0310-0051 143 µM -0.284495183833752 0.375164342197378 no 2117 0.388015462185094 667 2065037 SGTC_141 0443-0274 32.331 µM -0.284747603506617 0.375064165339769 no 2118 0.387918758658974 677 1627241 SGTC_306 1672-3436 11.6 µM -0.285805940416058 0.374644238914141 no 2119 0.387513379020388 697 6797378 SGTC_3088 9117578 49.47 µM -0.285885479755144 0.374612685330421 no 2120 0.387482917650734 657 678341 SGTC_1407 3909-7909 12.3 µM -0.286760449849206 0.374265636545983 no 2121 0.387147874033187 666 4411780 SGTC_1007 4101-0031 70 µM -0.287246132876104 0.37407303881651 no 2122 0.386961932513081 702 1146276 SGTC_1695 st026914 34.495 µM -0.288213484015391 0.373689529154913 no 2123 0.386591663885922 675 3289191 SGTC_2211 7117706 200 µM -0.288627991057075 0.373525234668648 no 2124 0.386433036469079 664 822771 SGTC_2489 cantharidin 73.42 µM -0.289094871936286 0.373340208753709 no 2125 0.386254388870263 687 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1693 xanthone 101.9 µM -0.289159675266304 0.373314529358914 no 2126 0.38622959438729 686 7020 An insecticide. SGTC_2926 9010726 65.15 µM -0.289817174811733 0.373054016087089 no 2127 0.385978053953069 711 2994293 SGTC_3229 9132204 49.47 µM -0.290931418893233 0.372612664887296 no 2128 0.385551885668077 664 17682924 SGTC_1801 st050089 28.441 µM -0.291776057700076 0.37227821550273 no 2129 0.385228926136016 669 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_193 1273-0060 1.558 µM -0.29181882219761 0.372261284717788 no 2130 0.385212576643546 695 2847393 YHR072W ERG7 SGTC_633 0437-0093 97.7 µM -0.292269904408792 0.372082712935089 no 2131 0.385040133752839 681 2831118 SGTC_2635 hydroquinidine 100 µM -0.292754371302537 0.371890955657219 no 2132 0.38485495364994 649 442912 An experimental heart treatment. SGTC_2912 7964298 10.93 µM -0.292964995198742 0.371807598330082 no 2133 0.384774454056933 664 2975850 SGTC_493 zm226600 134 µM -0.293002825426384 0.371792627129471 no 2134 0.384759996024512 713 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3254 9136651 49.47 µM -0.294074861663956 0.371368452634096 no 2135 0.384350349750312 696 16454030 SGTC_1427 4048-4900 550 nM -0.294244806512306 0.371301224580355 no 2136 0.38428542230473 695 24132586 SGTC_989 1501-0895 10.3 µM -0.294696396273858 0.371122600410527 no 2137 0.38411290817372 684 2830112 SGTC_567 1080-0542 68.4 µM -0.295967256465501 0.370620066846401 no 2138 0.383627543638333 653 5950415 SGTC_3062 9077494 49.47 µM -0.299237227748808 0.369328045176852 no 2139 0.382379523112893 645 16459633 SGTC_419 nsc-638432 893 µM -0.301312515726169 0.368508827221201 no 2140 0.381588098988611 685 368090 SGTC_3181 9108277 49.47 µM -0.302143464230073 0.368180978339646 no 2141 0.381271350079628 702 17097298 SGTC_2797 7859098 81.82 µM -0.302495091899003 0.368042273311334 no 2142 0.381137337208809 671 972681 SGTC_2049 5262831 67.185 µM -0.303411981566567 0.36768067280503 no 2143 0.380787957906413 688 763417 SGTC_781 4335-2806 94.4 µM -0.303483367688757 0.367652524652366 no 2144 0.380760760416013 713 845254 SGTC_23 0213-0011 39.996 µM -0.303954592931535 0.367466734389101 no 2145 0.380581242493276 694 627608 SGTC_1372 2752-0194 270 µM -0.304008432491185 0.367445509006781 no 2146 0.380560733415775 689 823334 SGTC_3151 9099821 49.47 µM -0.304826647081968 0.36712299091215 no 2147 0.38024909267255 721 17174189 SGTC_1464 k208-0027 110 µM -0.305199020373612 0.366976242442303 no 2148 0.380107289232954 664 X1464 SGTC_376 3970-0862 59.1 µM -0.306381418735544 0.366510400381305 no 2149 0.379657127128679 705 3135186 SGTC_2564 betulinic acid 100 µM -0.30656768104286 0.36643703454539 no 2150 0.379586228288472 719 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_981 1488-1094 54.9 µM -0.306910610188683 0.366301972836909 no 2151 0.379455706409912 654 3449522 SGTC_2788 5282734 71.43 µM -0.30903435285026 0.365465912003017 no 2152 0.378647697577571 725 743706 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.309658692699771 0.365220247387257 no 2153 0.378410259071707 733 6728940 SGTC_3014 9081533 49.47 µM -0.310097993237442 0.365047424990206 no 2154 0.378243219132506 724 21367265 SGTC_611 3453-1652 23.7 µM -0.31149526565593 0.364497915427266 no 2155 0.377712070727875 683 1560575 SGTC_2210 7115885 190.385 µM -0.313834914142987 0.363578418468715 no 2156 0.376823212712827 695 2927039 SGTC_1794 st048918 76.9 µM -0.314728796336764 0.363227324030845 no 2157 0.376483789112195 669 672303 SGTC_1728 st035614 33.7865 µM -0.315228451720852 0.363031122003828 no 2158 0.376294102306764 696 15945546 SGTC_1486 3970-0793 4.53 µM -0.320693330400547 0.360887558883882 no 2159 0.374221401061481 697 2844330 SGTC_1878 temozolomide 1 mM -0.320864719974997 0.36082040264553 no 2160 0.374156455392881 682 5394 DNA alkylating agent. SGTC_796 1234-0020 70.7 µM -0.321095823451348 0.360729855273099 no 2161 0.374068887636077 650 46495034 SGTC_2048 5246248 200 µM -0.321493236385802 0.36057416537137 no 2162 0.37391831851565 668 677046 SGTC_2314 7727897 200 µM -0.322031118710337 0.360363482199263 no 2163 0.373714559945128 666 900724 SGTC_57 miconazole 162.5 nM -0.322628622034254 0.360129495775118 no 2164 0.373488257348323 694 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_262 fenpropimorph 62.5 µM -0.323784252378833 0.359677091679322 no 2165 0.373050689645381 697 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1686 st019653 115.5 µM -0.323941703522782 0.359615468188914 no 2166 0.372991085026765 713 97252 SGTC_440 fluspirilene 35.1 µM -0.323984180171578 0.359598844232627 no 2167 0.372975005610556 693 3396 An atypical antipsychotic. SGTC_924 2046-0044 21.3 µM -0.324281401851012 0.359482528927095 no 2168 0.372862499370622 674 3623589 SGTC_1239 0337-0584 35.4 µM -0.324313686340296 0.3594698954364 no 2169 0.37285027949317 706 914301 YML130C ERO1 SGTC_3189 9110682 49.47 µM -0.324559133162694 0.359373852785014 no 2170 0.372757380548403 708 17122418 SGTC_1444 4112-3581 28 µM -0.326615246010389 0.358569651063926 no 2171 0.371979455397576 687 2877249 SGTC_1706 st031321 9.9705 µM -0.328635520712157 0.357780076970625 no 2172 0.37121559817428 681 6103185 SGTC_550 4123-0385 25.7 µM -0.329390634183466 0.357485115609697 no 2173 0.370930223011823 717 5731123 SGTC_2368 9071271 200 µM -0.32994779133871 0.357267534222867 no 2174 0.37071970569681 716 27209959 SGTC_1302 1159-0335 255 µM -0.332158502831644 0.356404663602761 no 2175 0.369884788230198 697 649284 SGTC_3111 9122088 49.47 µM -0.33218050290752 0.356396080359732 no 2176 0.36987648255467 705 16876704 SGTC_3306 9127676 59.7925 µM -0.333340000195774 0.355943810098411 no 2177 0.369438824222493 669 41905287 SGTC_2217 6934799 96.0675 µM -0.33352167114485 0.355872966384505 no 2178 0.369370266881965 701 675606 SGTC_1178 0988-0033 191 µM -0.333979440576285 0.355694478428276 no 2179 0.369197536416785 675 5392207 SGTC_2739 tacrine 100.86 µM -0.335837598907108 0.35497029284151 no 2180 0.368496667684124 699 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2766 oltipraz 83.91 µM -0.337253943253767 0.354418648253615 no 2181 0.36796273792557 702 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2465 5809242 33.21 µM -0.338949307726853 0.353758731021838 no 2182 0.367323959251633 720 2731748 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.338959184414602 0.353754887825742 no 2183 0.367320238991166 703 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2943 9068529 45.32 µM -0.340121506448435 0.353302711684668 no 2184 0.366882513215885 682 3270634 SGTC_19 0279-0214 38.434 µM -0.340255105362106 0.353250751181362 no 2185 0.366832211481654 682 3566274 YBR002C RER2 SGTC_375 3970-0961 9.27 µM -0.341514490756959 0.352761074124974 no 2186 0.366358148927065 687 2898222 SGTC_3094 9117742 49.47 µM -0.342364310087156 0.352430783188546 no 2187 0.366038371907955 705 17149698 SGTC_2723 salbutamol 83.58 µM -0.342429595344312 0.352405414006821 no 2188 0.366013809678627 716 9884233 β2-adrenoceptor agonist SGTC_1232 0279-0259 161 µM -0.342568414234111 0.352351472591788 no 2189 0.365961583764317 695 1560000 SGTC_2150 5556613 200 µM -0.34413584948709 0.351742614268252 no 2190 0.365372061787919 692 743190 SGTC_1252 0493-0875 34.8 µM -0.345807002684615 0.35109388609694 no 2191 0.364743881048672 683 3960963 SGTC_601 0986-0029 62.9 µM -0.346046796080419 0.351000835775938 no 2192 0.364653773273428 686 24747981 SGTC_1433 4060-0023 7.6 µM -0.346503302344556 0.350823716085145 no 2193 0.364482251421267 680 3840627 SGTC_2063 5246145 200 µM -0.347062456203057 0.350606814362093 no 2194 0.364272199037366 720 711240 SGTC_1573 oleylamine 1.06 µM -0.347301262209057 0.350514193809763 no 2195 0.364182501315186 720 5356789 An amine of the fatty acid oleic acid. SGTC_2708 st078559 56 µM -0.347458270819309 0.350453303096712 no 2196 0.364123531496754 696 17250902 SGTC_2876 9059903 25.97 µM -0.347759644079864 0.350336435989918 no 2197 0.364010349735332 695 6916095 SGTC_2272 7805186 180 µM -0.348117998699079 0.350197490981661 no 2198 0.363875783867481 747 2956062 YPR165W RHO1 SGTC_101 0490-5701 117.494 µM -0.349392310294064 0.349703564057037 no 2199 0.363397402758114 710 4661669 SGTC_3171 9103192 49.47 µM -0.349475041412633 0.349671506013573 no 2200 0.363366352555509 704 13018434 SGTC_1765 st044815 90.4 µM -0.34990077572126 0.349506552287887 no 2201 0.363206582423627 686 645695 SGTC_818 4072-2707 53.5 µM -0.349929271849795 0.349495512278493 no 2202 0.363195889208479 678 882871 SGTC_1763 st044482 94.5 µM -0.351064804490761 0.349055686357296 no 2203 0.362769865737982 709 88505 SGTC_2891 9063876 19.48 µM -0.35109673920524 0.349043320010208 no 2204 0.362757887083665 689 6472478 SGTC_1888 azatryptophan 97.5 µM -0.351812979030028 0.348766006601431 no 2205 0.362489262111657 700 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_61 0978-8327 98.565 µM -0.352173011564079 0.348626639866835 no 2206 0.362354257852476 727 6150059 YHR072W ERG7 SGTC_2196 6573537 42.6665 µM -0.353196473864162 0.348230574517487 no 2207 0.361970575602961 732 2903087 SGTC_1590 st077108 57.8 µM -0.353481389700528 0.348120345566102 no 2208 0.361863789148335 705 5489485 SGTC_1107 amlodipine 47 µM -0.35381720100456 0.347990442522402 no 2209 0.361737940880508 708 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1066 ketoconazole 628 nM -0.354489835955919 0.347730298486349 no 2210 0.361485909941077 725 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1060 3448-7350 82 µM -0.361329365377435 0.345089173931876 no 2211 0.358926622036645 726 570178 SGTC_2267 7931562 200 µM -0.362774453020807 0.344532103882399 no 2212 0.358386688608756 692 934880 SGTC_1625 st003711 30.1 µM -0.362937603328558 0.344469231857902 no 2213 0.358325747916898 699 24207034 YER133W GLC7 SGTC_691 1548-0686 185 µM -0.36299400902523 0.344447496212263 no 2214 0.358304679827674 692 46495133 SGTC_2956 9076196 2.52 µM -0.363026268365496 0.34443506547199 no 2215 0.358292630836839 720 16423868 SGTC_462 ag-879 158 µM -0.363418216925804 0.34428404633788 no 2216 0.358146247778963 723 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_921 1561-0023 372 µM -0.365477688599716 0.343490933206875 no 2217 0.357377429280901 711 24050882 SGTC_2161 5662504 8.5105 µM -0.366068871120772 0.343263392826359 no 2218 0.357156842493291 667 2859334 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.366771650294336 0.342992973891541 no 2219 0.356894677967527 693 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1795 st049545 62.3 µM -0.367298330996033 0.342790367716483 no 2220 0.356698249447296 673 5291882 SGTC_852 0418-0143 439 µM -0.36805093907732 0.342500929128953 no 2221 0.356417625994885 714 5369229 SGTC_639 0833-0042 114 µM -0.369877266601396 0.341798943409606 no 2222 0.355736970358929 726 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_89 0302-0250 142.109 µM -0.370400298959149 0.341598005992213 no 2223 0.355542125542343 701 4203518 YLR208W SEC13 SGTC_482 fipronil 114 µM -0.370915100636163 0.341400274445553 no 2224 0.355350383751918 681 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1270 0831-1170 17.3 µM -0.371714300363547 0.341093393949229 no 2225 0.355052788298107 715 6764716 SGTC_1965 Pectolinarigenin 58.4 µM -0.371888492375592 0.341026520816869 no 2226 0.354987936701217 699 5320438 An anti-inflammatory. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.371961505800325 0.340998492105013 no 2227 0.354960755089936 730 688751 SGTC_976 1348-1067 47.6 µM -0.372649193219229 0.340734542733046 no 2228 0.354704777419737 690 5310671 YGL099W LSG1 SGTC_429 1112-0049 25.5 µM -0.373695744040964 0.340333003422388 no 2229 0.354315346035503 686 2836170 SGTC_2222 6885208 172.143 µM -0.375346304480655 0.339700086349873 no 2230 0.353701466605962 690 609514 SGTC_372 0155-0182 15.9 µM -0.377235056949421 0.338976387368495 no 2231 0.352999464908766 707 771486 SGTC_2982 9019404 25.97 µM -0.379302136479831 0.338185040740754 no 2232 0.352231756654439 685 22333232 SGTC_2195 6536160 144.242 µM -0.380019911498481 0.337910419559341 no 2233 0.351965317373891 694 3834386 SGTC_834 0312-0008 75.7 µM -0.381441694218616 0.337366699328617 no 2234 0.351437763905252 729 6385573 YIL048W NEO1 SGTC_1071 trifluoperazine 6.31 µM -0.381628492536325 0.337295288845923 no 2235 0.351368473498097 740 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2706 st078239 82.5 µM -0.384067019690507 0.336363611204003 no 2236 0.350464387430064 719 15434492 SGTC_2675 theaflavin digallate 100 µM -0.384593213209409 0.336162702191976 no 2237 0.350269411583037 728 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_637 1181-0519 7.26 µM -0.385739828053564 0.335725068628026 no 2238 0.349844681417588 718 6252091 YGR060W ERG25 SGTC_111 0083-0039 52.457 µM -0.389058340248224 0.334459734089534 no 2239 0.348616495029606 690 759313 SGTC_2865 9030313 51.95 µM -0.389069728037649 0.334455395199772 no 2240 0.348612283113258 711 42562754 SGTC_917 harmaline 728.087 nM -0.389073846947843 0.334453825849075 no 2241 0.348610759687402 701 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2483 5729050 27.16 µM -0.389105308306459 0.33444183881619 no 2242 0.348599123426071 737 2865180 SGTC_577 r071-0003 38.6 µM -0.389241012208311 0.334390136462914 no 2243 0.348548933771975 703 4568517 YMR134W ERG29 SGTC_543 3844-1095 191 µM -0.389496501469205 0.334292805148074 no 2244 0.348454449080432 727 4230703 SGTC_906 1165-0455 526 µM -0.390772037234372 0.3338070431652 no 2245 0.347982872922085 743 3252859 SGTC_357 1325-0123 420 µM -0.390993667105343 0.333722668280005 no 2246 0.347900958464253 745 1098503 SGTC_2106 5357045 167.29 µM -0.393121506319665 0.332913024515821 no 2247 0.347114870246925 713 668842 SGTC_1634 st006576 41 µM -0.394217248171795 0.332496397626967 no 2248 0.346710326234074 735 3915356 SGTC_2759 disulfiram 3.38 µM -0.398163329211814 0.330997721374811 no 2249 0.345254897540416 695 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_892 0929-0076 29 µM -0.399104185196646 0.330640793384294 no 2250 0.344908219302109 687 5751038 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.399676026220144 0.330423932016757 no 2251 0.344697575987939 727 5355888 SGTC_1769 st044406 64.4 µM -0.400754485284216 0.330015099013186 no 2252 0.34430044593775 741 670903 SGTC_922 1866-0035 480 µM -0.402387416338078 0.329396457597552 no 2253 0.343699464750951 722 3156169 SGTC_647 0140-0236 81 µM -0.403011935008003 0.329159979886738 no 2254 0.343469722240112 720 990837 SGTC_1426 4048-4480 71.7 µM -0.403024102122148 0.329155373414965 no 2255 0.343465246881634 720 14224343 SGTC_35 0133-0054 64.071 µM -0.4044889837295 0.328600958691077 no 2256 0.342926588578962 736 99677 SGTC_374 0880-0231 82.3 µM -0.404752275612877 0.328501350379961 no 2257 0.342829806119215 724 6833587 SGTC_1863 st057641 20.1 µM -0.405153539356142 0.328349568139557 no 2258 0.342682326947436 729 3921635 SGTC_3102 9121669 49.47 µM -0.405390428174572 0.328259975743391 no 2259 0.342595272854359 715 41905072 SGTC_2170 morpholine 200 µM -0.407285744335515 0.327543514822538 no 2260 0.341899065899681 726 121171 Reacts with secondary amines. SGTC_1049 3226-0134 66 µM -0.407798125946227 0.327349934942201 no 2261 0.341710944795981 725 5702385 SGTC_2623 humulene 100 µM -0.409367126699767 0.326757448890389 no 2262 0.341135130196444 732 6187145 An anti-inflammatory. SGTC_258 haloperidol 50.781 µM -0.411366699250082 0.326003003149985 no 2263 0.340401834124443 713 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1971 st069429 63.5 µM -0.411971147868749 0.32577508251739 no 2264 0.340180285415285 735 1246522 YGL099W LSG1 SGTC_939 1165-0479 45.3 µM -0.412370948390766 0.325624364711744 no 2265 0.34003377673137 731 1377347 SGTC_2977 9011197 71.43 µM -0.412625269857172 0.32552850479671 no 2266 0.339940592063333 761 2704722 SGTC_472 calcifediol 10 µM -0.412987974569196 0.325391812577477 no 2267 0.339807712145587 718 5283731 A vitamin D metabolite. SGTC_2860 9025725 38.96 µM -0.414413617463901 0.324854759456918 no 2268 0.339285608894451 745 40546248 SGTC_1668 st014914 51.6 µM -0.414569887126894 0.324795913307131 no 2269 0.339228398083484 721 2839556 SGTC_1920 st075728 45.7 µM -0.414654544408562 0.324764035912154 no 2270 0.339197406336349 744 3400306 SGTC_2141 5621638 7.665 µM -0.414672035430514 0.324757449890695 no 2271 0.339191003274034 742 2856238 SGTC_2990 9074105 71.4286 µM -0.415316024654906 0.324515002108296 no 2272 0.338955285922642 741 6502001 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.416496741258044 0.324070681457426 no 2273 0.338523275729591 721 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2027 5150920 200 µM -0.416616782455807 0.324025522244852 no 2274 0.338479365966161 728 786715 SGTC_1997 st073024 93.8 µM -0.417555923275947 0.32367230912778 no 2275 0.338135914311048 727 686268 SGTC_2307 7538926 6.34 µM -0.417946670192279 0.323525395029967 no 2276 0.337993054548701 706 96582 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.420239268071973 0.322663972507879 no 2277 0.337155335544804 701 3256 An antibiotic and ribosome inhibitor. SGTC_2144 5628481 200 µM -0.421915023652943 0.322034924001695 no 2278 0.336543521844554 719 2818399 SGTC_2153 5569715 200 µM -0.422246561710188 0.321910530897845 no 2279 0.336422529415789 726 2054701 SGTC_1887 st057648 70.8 µM -0.422644457866116 0.321761266575139 no 2280 0.336277342438033 731 688672 SGTC_572 0960-0087 17.7 µM -0.423533255480066 0.32142795239534 no 2281 0.335953120296396 719 6796365 SGTC_3258 9138477 49.47 µM -0.423535412927429 0.321427143490763 no 2282 0.335952333435228 721 4970355 SGTC_231 b-estradiol 524 µM -0.424639507765734 0.321013289831408 no 2283 0.335549743921883 703 450 A steroid. SGTC_627 1391-0720 175 µM -0.424921665610531 0.320907562762315 no 2284 0.335446890093505 733 997839 SGTC_2358 9037157 4 µM -0.424929307724101 0.32090469939592 no 2285 0.335444104517037 731 2388925 SGTC_1490 4089-0339 670 nM -0.425345378842454 0.32074882090105 no 2286 0.335292458831471 736 742542 SGTC_2821 7996764 71.43 µM -0.425437238063097 0.32071441066436 no 2287 0.335258982462752 682 2987135 SGTC_2251 lansoprazole 556 µM -0.428369683574654 0.319616734702674 no 2288 0.334190996484096 752 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1770 st043884 66.3 µM -0.430074981987819 0.318979130783391 no 2289 0.33357054906638 755 670149 SGTC_774 k060-0086 136 µM -0.430243500348249 0.318916151507763 no 2290 0.333509260844391 760 5911235 SGTC_2953 9074162 66.49 µM -0.43070607137571 0.318743304708602 no 2291 0.333341051835457 714 16451992 SGTC_1744 st037937 38.9 µM -0.43154598732144 0.318429557961891 no 2292 0.333035711063352 752 1016152 SGTC_1173 0443-0020 122 µM -0.434175009170445 0.317448341141474 no 2293 0.332080679622061 734 5331295 SGTC_754 3474-0146 171 µM -0.434640994046687 0.317274557400877 no 2294 0.331911517174281 711 24762078 SGTC_2556 citropten 84.59 µM -0.434860212237263 0.317192816408306 no 2295 0.331831948143266 704 2775 A potential DNA crosslinker. SGTC_2842 9000675 19.48 µM -0.435738934765889 0.316865252253234 no 2296 0.33151307678299 711 2989072 SGTC_7 0192-1582 4.227 µM -0.436618443291519 0.316537538788238 no 2297 0.331194042433969 756 252616 SGTC_2058 5236698 133 µM -0.436935381689204 0.316419479722771 no 2298 0.331079105698148 706 766665 SGTC_1028 k015-0029 4.8 µM -0.437288706084543 0.316287888979452 no 2299 0.330950992453699 743 4588309 SGTC_2414 st077232 92.9 µM -0.437816262153152 0.316091451378008 no 2300 0.330759740723369 697 729801 SGTC_1478 0453-0656 35.7 µM -0.43983440296505 0.315340468077422 no 2301 0.330028524307884 758 5258496 SGTC_2376 9072922 81.32 µM -0.440986594433584 0.314912060336635 no 2302 0.329611350996077 749 17087968 SGTC_1399 3562-5772 25 µM -0.440992349199788 0.3149099212242 no 2303 0.329609267902624 732 23847490 SGTC_2854 9024559 71.43 µM -0.441277862052017 0.314803800627664 no 2304 0.329505925433271 760 3163529 SGTC_3168 9103419 49.47 µM -0.443070198685151 0.314137967123336 no 2305 0.32885748000355 738 16649256 SGTC_2484 5809818 12.04 µM -0.443834149517365 0.313854351323585 no 2306 0.328581248315438 728 2870548 SGTC_66 0109-0187 42.4 µM -0.443843850431042 0.313850750577997 no 2307 0.328577741231125 708 759417 SGTC_3230 9131665 49.47 µM -0.444755239391837 0.313512544047077 no 2308 0.328248322341184 731 15943720 SGTC_2934 9036370 36.88 µM -0.445003320614487 0.313420510927043 no 2309 0.328158677210748 718 6462800 SGTC_2159 5658611 73.75 µM -0.445249008492713 0.313329377137559 no 2310 0.328069906678024 740 793844 SGTC_3289 9119912 71.43 µM -0.44581910994356 0.313117951500031 no 2311 0.327863958312224 778 17014829 SGTC_2405 ticlatone 3.52 µM -0.445876573983428 0.31309664401337 no 2312 0.327843202409473 727 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1097 itavastatin 7.23 µM -0.446317751819986 0.312933077442575 no 2313 0.327683867526016 721 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1011 4112-3381 17.4 µM -0.446373593383628 0.312912376821284 no 2314 0.327663702137455 764 2877139 SGTC_790 1575-0012 79.1 µM -0.446736911590701 0.312777708168242 no 2315 0.327532513703157 750 378741 YLR208W SEC13 SGTC_1715 st032160 10.2275 µM -0.446961352320402 0.312694528754835 no 2316 0.327451482358261 741 5289825 SGTC_298 1391-0729 10 µM -0.447504632799219 0.312493224438577 no 2317 0.327255371813467 731 3237558 SGTC_1843 st055809 45.5 µM -0.451915273872652 0.31086100324006 no 2318 0.32566501031788 740 16413835 SGTC_2442 5158906 48.48 µM -0.452688865571638 0.310575106489619 no 2319 0.325386399168588 736 1893835 SGTC_2760 etidronate 98.04 µM -0.454008183573278 0.310087789257705 no 2320 0.324911468333331 738 3305 A chelator and antioxidant. SGTC_2038 4100038 30.985 µM -0.454457257744388 0.309921990485382 no 2321 0.32474987452287 727 3596803 SGTC_2134 5324836 1.464 µM -0.455621004260617 0.309492513665255 no 2322 0.324331268184515 758 699272 SGTC_1839 st053978 48 µM -0.457153402916404 0.308927383692202 no 2323 0.323780394086847 732 3788398 SGTC_2140 5586273 200 µM -0.458118609499387 0.308571659170229 no 2324 0.323433614898325 742 854421 SGTC_2097 5376186 200 µM -0.458166433753551 0.308554038325539 no 2325 0.323416436595879 725 742755 SGTC_2930 9013230 14.89 µM -0.459811163046974 0.307948306419281 no 2326 0.322825884942556 741 2995857 SGTC_435 c-PAF 6.7 µM -0.460911326632537 0.307543422550407 no 2327 0.322431112560418 742 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1235 benzylparaben 21.5 µM -0.462248799634003 0.307051519343555 no 2328 0.321951455868159 759 7180 SGTC_1939 st074455 53.6 µM -0.462282185561994 0.307039244919071 no 2329 0.3219394864936 772 1644229 SGTC_2809 7964133 12.99 µM -0.462727414480458 0.306875576008558 no 2330 0.321779882662567 768 1253665 SGTC_764 1951-2361 146 µM -0.464370073024155 0.306272057678836 no 2331 0.32119131380142 742 5438930 SGTC_1403 3909-7815 62.9 µM -0.465026126220477 0.306031168195574 no 2332 0.320956373565058 740 6615483 SGTC_2722 naftopidil 47.16 µM -0.465501912139305 0.305856521671087 no 2333 0.320786033953668 767 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1283 0922-0125 16.4 µM -0.467048766734077 0.305289023626155 no 2334 0.320232494019996 731 3360884 SGTC_2184 6075246 200 µM -0.468305332017697 0.304828368856676 no 2335 0.319783127967854 752 2267320 SGTC_2704 st078022 71.1 µM -0.469802520785317 0.304279905612919 no 2336 0.319248056632695 771 54697681 SGTC_1808 st050063 61.5 µM -0.469973916858323 0.304217146353431 no 2337 0.319186826398436 785 4011993 SGTC_1058 3448-5425 97.3 µM -0.470500102185169 0.304024511686642 no 2338 0.31899888061818 760 7279705 SGTC_3089 9117425 49.47 µM -0.470687936273336 0.303955759434931 no 2339 0.318931800267574 778 9401657 SGTC_407 eburnamonine 100 µM -0.471268478226554 0.303743309541171 no 2340 0.318724511405518 754 3195 SGTC_3290 9121031 71.43 µM -0.471295005726912 0.303733603359837 no 2341 0.318715040825333 717 17014854 SGTC_1610 st001799 48.1 µM -0.471774065491872 0.303558343390001 no 2342 0.318544032129144 725 621897 SGTC_1564 D-Arginine 115 µM -0.472520884695968 0.303285216004756 no 2343 0.318277519146938 789 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_886 0866-0150 153 µM -0.473084716563457 0.303079083715445 no 2344 0.318076370069463 745 271463 SGTC_3018 9082602 49.47 µM -0.47422838307306 0.302661161277199 no 2345 0.317668527688829 758 17332089 SGTC_3308 9128332 17.569 µM -0.47434000351764 0.30262038639463 no 2346 0.317628734612056 752 17332805 YDL196W YDL196W SGTC_471 1-acyl-paf 4 µM -0.474573958925598 0.302534930610074 no 2347 0.317545335531531 729 16759367 SGTC_3215 9129942 49.47 µM -0.47597649838113 0.302022858629662 no 2348 0.317045560579506 775 17682944 SGTC_167 3672-0051 66.205 µM -0.476512892233897 0.301827122343593 no 2349 0.316854512400222 749 3237971 SGTC_2110 5483698 200 µM -0.477302584878047 0.30153905821903 no 2350 0.316573335288138 738 2848765 YHR062C RPP1 SGTC_3140 9094243 49.47 µM -0.478726534414357 0.301019942706167 no 2351 0.316066593238971 777 19291112 SGTC_1591 genipin 88.4 µM -0.479354519718216 0.300791132257261 no 2352 0.315843221292025 776 442424 A DNA cross-linking agent. SGTC_1000 4048-0884 8.67 µM -0.479546306503469 0.300721269163732 no 2353 0.315775016871639 764 13040088 SGTC_2459 5811157 9.22 µM -0.481038155453547 0.300178076390967 no 2354 0.315244690497315 752 2870684 YBR192W RIM2 SGTC_2448 5185112 27.17 µM -0.482288218111916 0.299723261647934 no 2355 0.314800607862406 724 5718189 SGTC_3342 9147791 14.508 µM -0.482772235878879 0.299547243602441 no 2356 0.314628733224109 764 1838168 SGTC_1784 st039334 36.3 µM -0.482879045367056 0.299508407542849 no 2357 0.314590810597959 773 3496984 SGTC_2952 9073731 13.78 µM -0.48521633912075 0.298659136769892 no 2358 0.313761446523417 767 16457353 SGTC_181 1447-1644 8.07 µM -0.486168572516317 0.298313450814918 no 2359 0.313423825840549 766 534600 SGTC_3279 9140807 49.47 µM -0.48753661406615 0.297817134580284 no 2360 0.312939051185642 759 45595718 SGTC_2768 sulfasalazine 50.2 µM -0.488721140309185 0.297387700918145 no 2361 0.312519567472537 797 5384001 An antioxidant and salicylic acid derivative. SGTC_1771 st048882 4.1505 µM -0.48924810101114 0.297196749526254 no 2362 0.312333029568957 747 4580403 SGTC_1139 k015-0024 46.9 µM -0.48936060879496 0.297155988058751 no 2363 0.312293209361866 781 2766652 SGTC_2078 5212016 200 µM -0.489485353458686 0.297110796168935 no 2364 0.312249060683256 771 1899708 SGTC_678 1218-2179 85.9 µM -0.489846092611363 0.29698012703095 no 2365 0.312121405808565 758 6820081 YOR116C RPO31 SGTC_1098 clofazimine 15.1 µM -0.490716591370566 0.296664917967607 no 2366 0.311813455054903 774 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2456 5770359 74.46 µM -0.490883319569628 0.296604562894163 no 2367 0.31175448769294 783 3118787 SGTC_210 3551-0445 56.827 µM -0.49249235804068 0.296022385418318 no 2368 0.311185661471955 778 2865180 YOR207C RET1 SGTC_308 4092-1169 104 µM -0.492636496223915 0.295970259380977 no 2369 0.311134727809291 764 2268590 YDL196W YDL196W SGTC_2429 5902844 64.44 µM -0.493713531936694 0.295580894356864 no 2370 0.310754253571403 771 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1017 4239-0030 168 µM -0.49401419683447 0.295472241419895 no 2371 0.310648076620141 733 1149593 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.494887751348728 0.295156664458705 no 2372 0.310339678638669 766 688669 SGTC_3053 9095903 49.47 µM -0.494915988680388 0.295146466138139 no 2373 0.31032971200923 780 17174018 SGTC_2007 4011539 71.82 µM -0.49644646642362 0.294593954869845 no 2374 0.309789724142856 768 45595301 SGTC_252 miconazole 1.30953 nM -0.497219041365353 0.294315232229137 no 2375 0.309517297583341 769 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3294 9122953 26.2835 µM -0.497355510873588 0.294266010645925 no 2376 0.309469186366153 762 16459826 SGTC_1753 st043925 64 µM -0.498203208822565 0.293960349633004 no 2377 0.309170410500579 761 670181 SGTC_406 estrone 100 µM -0.498908943463479 0.293705989473712 no 2378 0.308921766619875 765 5870 A steroid. SGTC_1196 1588-0294 184 µM -0.500589952160801 0.293100532682088 no 2379 0.30832986766827 779 6144269 SGTC_1935 st074532 41.6 µM -0.500750840271434 0.293042615221971 no 2380 0.308273243539284 761 2829742 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.501694885871935 0.292702879086312 no 2381 0.307941081230826 763 688803 SGTC_248 streptozotocin 5.23457 mM -0.501956055753796 0.292608923518743 no 2382 0.307849216410976 792 5300 DNA alkylating agent. SGTC_3064 1327-0027 10 µM -0.502247884124827 0.29250395517332 no 2383 0.307746581911435 731 16000455 YPR107C YTH1 SGTC_2543 pimpinellin 60.67 µM -0.502430086114561 0.292438427441558 no 2384 0.307682510059305 745 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1442 4112-3290 3 µM -0.503644619396409 0.29200180309758 no 2385 0.307255565877223 780 704353 SGTC_2129 girgensonine 121.053 µM -0.504574375143166 0.291667761436537 no 2386 0.306928905783654 766 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2521 angolensin 13.4 µM -0.504608616961476 0.291655462473833 no 2387 0.306916878197802 750 821428 A flavenoid. SGTC_727 3032-0951 202 µM -0.504703590258042 0.291621351268097 no 2388 0.306883519506794 763 3652836 SGTC_2896 9052656 71.43 µM -0.505217213609549 0.291436907315478 no 2389 0.306703140690843 773 6469436 SGTC_2266 7929956 200 µM -0.505516067779509 0.291329612782206 no 2390 0.306598207961514 771 2967153 SGTC_2888 9058547 12.99 µM -0.506159392158973 0.291098709232647 no 2391 0.306372379740865 743 16476514 SGTC_78 0336-0123 156.75 µM -0.507160525609663 0.290739550086442 no 2392 0.306021094914127 752 6765896 SGTC_501 nsc-95397 161 µM -0.50761364168736 0.290577061700493 no 2393 0.305862160922515 771 262093 SGTC_561 1550-0330 72.9 µM -0.508335636885946 0.290318240519856 no 2394 0.305608991018093 763 6812934 SGTC_1986 st071812 45 µM -0.508618693291939 0.290216799794004 no 2395 0.305509761737018 777 11838594 SGTC_2478 5763493 32.33 µM -0.509345528621726 0.289956395282543 no 2396 0.305255025154566 749 1365576 YLR208W SEC13 SGTC_1373 2887-0003 58.5 µM -0.509858544256955 0.289772662292081 no 2397 0.305075283482723 745 776948 SGTC_1606 st000094 49.2 µM -0.510000162155145 0.289721952447062 no 2398 0.305025674095891 760 1242210 SGTC_1456 k015-0012 13 µM -0.51285389891076 0.288700988930655 no 2399 0.304026761813649 768 2989616 SGTC_2762 leflunomide 42.06 µM -0.513167008925955 0.288589072748855 no 2400 0.303917250680586 780 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3027 9089541 49.47 µM -0.513268217929093 0.288552901576187 no 2401 0.303881856301529 764 9943819 SGTC_1333 1482-0047 286 µM -0.513453949198398 0.28848652847549 no 2402 0.303816907940724 783 3811116 SGTC_680 0417-1641 114 µM -0.514411931258491 0.288144297421545 no 2403 0.30348200962302 750 2835990 SGTC_596 1155-0152 116 µM -0.515607200544221 0.287717566292517 no 2404 0.303064390102817 759 280313 SGTC_1833 st055984 71 µM -0.51612602328861 0.287532430878909 no 2405 0.302883196775171 736 676288 SGTC_624 k048-0052 28 µM -0.51831467386205 0.286752058884897 no 2406 0.302119368240827 746 6835531 SGTC_83 0170-0301 39.027 µM -0.519099336156244 0.286472529158242 no 2407 0.301845735622886 758 3089716 SGTC_2808 7946468 45.46 µM -0.519387837341271 0.286369785415624 no 2408 0.301745155595144 785 2970879 SGTC_402 epigallocatechin gallate 10 µM -0.520327730182455 0.286035183348841 no 2409 0.301417585765613 777 65064 An antioxidant. SGTC_848 0368-0089 85.6 µM -0.521399899538062 0.285653717809787 no 2410 0.301044110721812 782 762535 SGTC_2390 9097792 176.6 µM -0.522759171357332 0.285170452769453 no 2411 0.30057092767799 750 4497149 SGTC_389 tpck 16.7 µM -0.523688114020163 0.284840407942908 no 2412 0.300247742014314 752 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2308 7584454 197.62 µM -0.524405460610882 0.28458566603644 no 2413 0.299998279652958 779 893577 SGTC_2735 sertaconazole 140 nM -0.524503182906563 0.284550971617927 no 2414 0.299964303291308 780 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2243 6634756 200 µM -0.524664544851362 0.284493687589939 no 2415 0.299908204330019 735 885676 SGTC_2200 6600604 21.907 µM -0.524926122574197 0.284400838331168 no 2416 0.299817274523477 799 2904777 SGTC_560 2332-1943 155 µM -0.526772731092275 0.283745781028227 no 2417 0.299175710773 784 21177716 SGTC_223 busulfan 5 mM -0.526785187658028 0.283741364698525 no 2418 0.299171385127904 769 2478 A DNA alkylator. SGTC_2691 st077356 60.2 µM -0.527557676616481 0.283467552108981 no 2419 0.298903187452124 769 2839272 SGTC_1831 st055328 12 µM -0.527762568171748 0.283394948524818 no 2420 0.298832070217755 778 1103068 SGTC_1195 1502-0147 41.1 µM -0.528979558335219 0.282963890346534 no 2421 0.298409815198552 762 817940 SGTC_642 0335-0876 158 µM -0.529361159540178 0.282828791974293 no 2422 0.298277468243019 777 6812350 SGTC_1872 amphotericin b 148 nM -0.532300148232519 0.281789340551574 no 2423 0.297259064792194 761 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2775 cyproheptadine 69.59 µM -0.533238806597951 0.281457747445369 no 2424 0.296934140773164 783 2913 A selective serotonin reuptake inhibitor. SGTC_2851 9015922 71.43 µM -0.533620723467448 0.281322884318728 no 2425 0.296801983751836 792 2996893 SGTC_706 4262-0057 46.9 µM -0.534241624333233 0.281103697363478 no 2426 0.296587187129277 770 883298 SGTC_1330 1469-0054 61.8 µM -0.535210242483396 0.280761926011782 no 2427 0.296252242244479 772 7102664 SGTC_2898 9056270 58.44 µM -0.53674299350109 0.28022151455285 no 2428 0.295722576900786 747 19154699 SGTC_1773 st048542 73.5835 µM -0.537332110821591 0.280013939979671 no 2429 0.295519114313847 788 3237138 SGTC_159 3970-0959 50 µM -0.538154854037263 0.279724172486566 no 2430 0.295235072470746 765 6615653 SGTC_1272 0839-0021 27 µM -0.538265872670583 0.279685083228252 no 2431 0.295196754295857 771 5027250 SGTC_1819 st053448 58.6 µM -0.5414664347694 0.278559318196945 no 2432 0.294093063444528 800 2857616 SGTC_879 0831-1030 162 µM -0.541801489241006 0.278441593949779 no 2433 0.293977632679931 781 1549252 SGTC_2271 7849410 118.62 µM -0.542219971387976 0.278294590733747 no 2434 0.293833489389796 792 972430 SGTC_2228 7354201 200 µM -0.542360982068062 0.278245065427389 no 2435 0.29378492659889 789 753451 SGTC_3266 9136860 49.47 µM -0.542436800595491 0.278218438470574 no 2436 0.29375881692544 763 4871271 YPR165W RHO1 SGTC_3227 9130768 49.47 µM -0.542953997511009 0.278036835546044 no 2437 0.293580738153049 778 17720899 SGTC_750 4073-0104 132 µM -0.544607061015745 0.277456784860607 no 2438 0.293011898682042 773 22330957 SGTC_3333 9141820 12.094 µM -0.544636032912039 0.277446624061844 no 2439 0.293001933657477 761 1939433 SGTC_2950 9072895 21.46 µM -0.544734886643924 0.277411956216874 no 2440 0.292967933619439 767 17332245 SGTC_2805 7950783 58.44 µM -0.54547821314642 0.277151340660797 no 2441 0.292712330414446 762 1178958 YDL195W SEC31 SGTC_1758 st042942 75.2445 µM -0.545925818583936 0.27699446482062 no 2442 0.292558465007346 771 669317 SGTC_1228 0124-0032 52.5 µM -0.546436062012619 0.276815688780456 no 2443 0.292383113500065 760 X1228 SGTC_1315 1237-0019 3.69 µM -0.547473973432671 0.276452206086683 no 2444 0.292026573205186 760 825140 SGTC_1561 5-methoxyflavone 52.9 µM -0.54983861095075 0.275624971158982 no 2445 0.291215036627313 772 94525 SGTC_1508 1080-0625 72.9 µM -0.549843450763333 0.275623279267988 no 2446 0.291213376698223 785 767111 SGTC_3233 9132340 49.47 µM -0.55038080474753 0.275435464012106 no 2447 0.291029105818462 826 17682950 SGTC_3267 9137951 49.47 µM -0.550794974619438 0.275290746884389 no 2448 0.290887114749929 785 16643986 SGTC_2043 5101342 149 µM -0.55136665402113 0.275091055079108 no 2449 0.290691177437593 776 678451 SGTC_1038 k292-0204 154 µM -0.55214845802869 0.274818080754443 no 2450 0.2904233220254 786 4454212 SGTC_2350 9023895 38.85 µM -0.552149653340418 0.274817663502205 no 2451 0.290422912585771 771 2997209 SGTC_1434 4073-0095 163 µM -0.552338332716378 0.274751804354384 no 2452 0.290358286127166 788 24133745 SGTC_1262 0737-0114 49.6 µM -0.553350078152011 0.274398784125579 no 2453 0.290011858006957 796 765919 SGTC_2204 7233102 200 µM -0.553648170987808 0.274294815696493 no 2454 0.289909826078204 777 2172480 SGTC_2427 5545055 42.75 µM -0.555772293729703 0.273554530541397 no 2455 0.289183264104041 771 5372858 SGTC_2966 9084041 48.03 µM -0.556012652860234 0.273470824489089 no 2456 0.289101102554433 774 17741380 SGTC_1034 k072-0165 12.7 µM -0.556771255124958 0.27320672133056 no 2457 0.288841862868607 797 5835461 SGTC_3337 9144342 33.5465 µM -0.557905749275317 0.272811989453364 no 2458 0.288454372700876 749 17682949 SGTC_1891 st059073 26.2 µM -0.557911777249939 0.27280989285705 no 2459 0.288452314481057 793 688754 SGTC_139 0099-0334 718.624 µM -0.558051619494027 0.272761256419907 no 2460 0.288404568034921 780 97690 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.558168261397988 0.272720692236558 no 2461 0.288364745748929 790 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2031 5180455 200 µM -0.558531329756873 0.272594448272889 no 2462 0.288240808503912 798 29949 SGTC_2850 9015429 58.44 µM -0.55856009754302 0.272584446550385 no 2463 0.288230989388538 799 6457570 SGTC_830 4076-0286 57.8 µM -0.559461055439092 0.2722713019179 no 2464 0.287923551352684 779 6866659 SGTC_1681 tripelennamine 100 µM -0.559568171464953 0.272234083648718 no 2465 0.287887009956281 758 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2199 6590217 200 µM -0.559856587028101 0.272133884061482 no 2466 0.287788631203041 760 703109 SGTC_2194 5927483 104.545 µM -0.560742343095812 0.271826274711729 no 2467 0.287486598501977 746 760979 SGTC_2000 st075254 36.4 µM -0.561843953642132 0.27144394400273 no 2468 0.28711117116067 748 17234175 SGTC_444 curcumin 90.4 µM -0.56331118637463 0.270935134927095 no 2469 0.28661150107344 771 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2343 7990716 14.84 µM -0.566681737583098 0.269768095538771 no 2470 0.285465215317605 806 6456862 SGTC_689 0833-0039 98 µM -0.567067518859887 0.269634681099361 no 2471 0.285334154875233 832 5374726 SGTC_117 lucigenin 22.078 µM -0.567183480347109 0.26959458469049 no 2472 0.285294765192221 806 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_3160 9100216 49.47 µM -0.568343523857925 0.269193636890903 no 2473 0.284900865407139 771 17191039 SGTC_1553 gossypol 38.6 µM -0.568384876084389 0.269179349774653 no 2474 0.284886828798785 789 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_187 1488-2104 32.728 µM -0.56883040755712 0.269025443623484 no 2475 0.28473561843177 776 2852859 SGTC_2653 dihydrofissinolide 100 µM -0.569031013529136 0.268956159927872 no 2476 0.284667546631475 773 6857746 SGTC_1468 k284-1086 134 µM -0.570300103548573 0.268518059396307 no 2477 0.2842370853421 784 15996457 SGTC_1158 4092-0494 91.8 µM -0.572017929321632 0.26792562349357 no 2478 0.283654914028507 781 1148199 SGTC_373 0844-0104 25.9 µM -0.572774072264742 0.267665057176755 no 2479 0.283398838279208 782 5375804 SGTC_315 k915-0449 187 µM -0.572846852705685 0.267639983828892 no 2480 0.283374196266882 783 20970215 YNL149C PGA2 SGTC_2920 7982904 15.77 µM -0.572994630074566 0.267589077181159 no 2481 0.28332416494459 789 6456808 SGTC_1422 4031-0024 15.5 µM -0.57411896662079 0.26720192336678 no 2482 0.282943649740393 806 782427 SGTC_1810 st050138 53 µM -0.574398290635741 0.267105784854407 no 2483 0.282849154692467 818 3444541 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.575246211738667 0.266814052032382 no 2484 0.282562396671108 788 16725076 SGTC_410 α-linolenic acid 100 µM -0.575687421187364 0.26666231473746 no 2485 0.282413239567665 788 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1990 st072050 59.8 µM -0.576927880278039 0.26623593964502 no 2486 0.281994087831022 779 17233948 SGTC_2347 9049783 174.81 µM -0.5771127770475 0.266172415823346 no 2487 0.281931636790231 819 6467988 YPL169C MEX67 SGTC_2969 9091408 28.7 µM -0.577657835133826 0.265985198305316 no 2488 0.281747575844034 768 4286311 SGTC_2826 7992541 19.48 µM -0.578335948004758 0.265752372053059 no 2489 0.281518664450452 838 2985066 SGTC_2937 9044753 11.33 µM -0.578718891735378 0.265620936131345 no 2490 0.281389433316664 757 6465530 YGL099W LSG1 SGTC_1867 st057372 64 µM -0.580803729021727 0.264905946309776 no 2491 0.280686370776891 763 688837 SGTC_1189 1431-2119 7.28 µM -0.581209888397388 0.264766768877446 no 2492 0.28054950199919 805 3107275 SGTC_2652 actinonin 100 µM -0.581592164079814 0.264635809571503 no 2493 0.280420711130464 789 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_996 3970-0799 1.8 µM -0.582039895861778 0.264482468338478 no 2494 0.28026990413145 777 6615648 YGL040C HEM2 SGTC_2485 5633444 17.78 µM -0.582951683949868 0.264170334833134 no 2495 0.279962913148762 770 5724239 SGTC_3156 9099931 49.47 µM -0.58322976235462 0.264075177272557 no 2496 0.279869319064949 795 18111053 SGTC_3154 9100113 49.47 µM -0.583924135109581 0.263837641361701 no 2497 0.279635677222915 797 25237525 SGTC_1382 3002-2117 298 µM -0.584116807449048 0.263771749967198 no 2498 0.279570863812453 826 1497314 SGTC_2595 hexamethylquercetagetin 100 µM -0.584968829433812 0.263480470347217 no 2499 0.279284338001181 812 386331 SGTC_149 3970-0822 46.1 µM -0.585320092083303 0.263360432465865 no 2500 0.279166253712984 785 3114250 YBL034C STU1 SGTC_216 k038-0035 28.382 µM -0.587091574055656 0.262755485206971 no 2501 0.278571103109049 788 4444231 YPR107C YTH1 SGTC_3004 9076122 71.4286 µM -0.587572779747736 0.262591280069681 no 2502 0.278409543086474 804 44782551 SGTC_2992 9074591 71.4286 µM -0.588411046383604 0.26230535803987 no 2503 0.278128212502346 802 17741321 SGTC_908 3448-7491 47.7 µM -0.588551652819298 0.262257414604022 no 2504 0.278081037173206 761 1203031 SGTC_1680 diphenhydramine 100 µM -0.589188776972283 0.262040226755936 no 2505 0.277867322477053 793 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2234 tolnaftate 200 µM -0.590367281592319 0.261638732049955 no 2506 0.277472220457153 801 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_789 1309-1135 70.6 µM -0.591456717602026 0.261267862388419 no 2507 0.277107223740525 780 3092424 SGTC_317 4495-0002 170 µM -0.591620434702271 0.261212152586691 no 2508 0.27705239346786 791 15991618 SGTC_2409 alverine citrate 63.97 µM -0.591787816107113 0.261155202203214 no 2509 0.276996341478038 747 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2025 5147754 141 µM -0.591836352417551 0.261138689247593 no 2510 0.276980088878267 777 315777 YLR208W SEC13 SGTC_3068 9116768 49.47 µM -0.59212951274446 0.261038962062064 no 2511 0.276881932763559 809 41904888 SGTC_2389 9091542 195.52 µM -0.593754332909523 0.260486586475398 no 2512 0.276338218556286 789 3626624 YOL127W RPL25 SGTC_617 3770-0098 35 µM -0.593869503956489 0.26044745566081 no 2513 0.276299698711501 801 5962639 SGTC_170 4197-0004 226 µM -0.596043028744706 0.259709541315111 no 2514 0.275573240969109 806 218692 SGTC_2703 st077852 53.4 µM -0.596475652847259 0.259562793768769 no 2515 0.275428757068257 817 6281836 SGTC_2071 5230951 39.92 µM -0.598151937426515 0.258994597027688 no 2516 0.274869278864763 807 1799272 SGTC_2013 4024628 200 µM -0.59945803135154 0.258552327151997 no 2517 0.274433744395497 814 5230760 SGTC_1945 st075991 56.6 µM -0.599771686622998 0.258446175389988 no 2518 0.274329202595036 783 1084980 SGTC_1455 4262-0120 131 µM -0.600662490194522 0.258144819894635 no 2519 0.274032403603424 793 1529587 SGTC_1023 4482-3888 16 µM -0.60087727089727 0.258072187660129 no 2520 0.273960866463006 803 3303168 SGTC_1474 0330-0125 5.35 µM -0.601322830909385 0.257921546757525 no 2521 0.273812492958892 801 X1474 SGTC_798 1287-0182 476 µM -0.602092504445944 0.257661432718858 no 2522 0.273556281826923 815 1649755 SGTC_3048 9093155 49.47 µM -0.602760937161118 0.25743564394919 no 2523 0.273333868336483 783 25236002 SGTC_2687 chenodiol 100 µM -0.603497061468998 0.257187108741345 no 2524 0.273089034892578 774 5702181 A cholesterol synthesis inhibitor. SGTC_2292 7671323 168.05 µM -0.603857247050539 0.257065545948141 no 2525 0.272969277518543 807 937504 SGTC_395 anisomycin 6.25 µM -0.60511951540993 0.256639765812279 no 2526 0.272549794103633 813 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1881 5652484 16 µM -0.606581413578504 0.256147107194126 no 2527 0.272064369002842 812 2255129 SGTC_1984 st072354 53.1 µM -0.60794053707814 0.255689526349315 no 2528 0.271613456299862 800 5762938 SGTC_2227 7312221 64.1025 µM -0.608255598083146 0.255583514635963 no 2529 0.271508982520884 815 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3034 9090421 49.47 µM -0.609467762634344 0.255175859742485 no 2530 0.271107217223368 788 17173761 SGTC_2597 laccaic acid a 100 µM -0.609749470114031 0.255081169313443 no 2531 0.271013889299093 799 5491415 A textile dye. SGTC_3180 9109287 49.47 µM -0.610814162753095 0.25472345989031 no 2532 0.270661308108346 791 18891271 SGTC_2832 7992762 51.95 µM -0.613286236643267 0.2538939204914 no 2533 0.269843546147329 778 2985177 SGTC_2591 skatole 100 µM -0.614225260275187 0.253579189806061 no 2534 0.269533241660649 814 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_369 0957-0393 4.5 µM -0.614779287821509 0.253393593672234 no 2535 0.269350244736541 813 6997992 SGTC_1087 pterostilbene 9.05 µM -0.61523678022947 0.253240390107357 no 2536 0.269199180627429 814 5281727 Similar to reservatol, lowers cholesterol. SGTC_1896 st058441 89 µM -0.615656090860906 0.253100015521077 no 2537 0.269060761489454 782 688759 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.615780223809397 0.253058466805493 no 2538 0.269019790665675 819 61125 An anti-inflammatory. SGTC_825 1988-2224 89.6 µM -0.616506936987522 0.252815299617136 no 2539 0.268779997469572 794 1180859 SGTC_3325 9138760 55.175 µM -0.617124967943979 0.252608595674024 no 2540 0.268576150605654 788 43844959 SGTC_397 arbidol 50 µM -0.617322511959113 0.252542544742971 no 2541 0.268511010507012 800 131410 A RNA synthesis inhibitor. SGTC_1361 1608-0041 5.61 µM -0.61920051034998 0.25191507083184 no 2542 0.2678921378481 808 X1361 SGTC_2111 5486399 200 µM -0.619910241400657 0.251678151018915 no 2543 0.267658441382356 788 689674 SGTC_999 SEC7.066 22.7 µM -0.619923890576176 0.251673595854889 no 2544 0.267653948061677 808 740511 YDR170C SEC7 SGTC_1729 st035615 45.989 µM -0.620150676859356 0.251597916431247 no 2545 0.267579295380565 809 17385451 SGTC_1168 k815-0004 80.5 µM -0.622754656703565 0.250729820895256 no 2546 0.266722879715909 817 642433 SGTC_44 0929-0055 61.211 µM -0.623197834115183 0.250582235792248 no 2547 0.266577262418704 786 1379590 SGTC_1147 3809-1045 12.3 µM -0.623232551574024 0.250570676272294 no 2548 0.266565856806014 796 325925 SGTC_1915 st067105 30.6 µM -0.62451237283998 0.250144744411085 no 2549 0.266145573630395 817 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2452 5863136 48.41 µM -0.624684730909209 0.250087412012992 no 2550 0.26608899825079 800 2184096 SGTC_2404 5161160 200 µM -0.625212312970588 0.249911962869986 no 2551 0.265915860841595 823 2831543 SGTC_1883 5-benzylidenerhodanine 20 µM -0.625496703757137 0.249817414888529 no 2552 0.265822555567418 799 1273210 SGTC_172 1112-0046 2.638 µM -0.626336372012143 0.249538371335383 no 2553 0.2655471671379 809 2802135 YIL048W NEO1 SGTC_2824 7998404 51.95 µM -0.626780015493603 0.249391003984406 no 2554 0.265401722554068 827 837851 SGTC_2186 6124449 200 µM -0.628375073839592 0.248861547572386 no 2555 0.264879130990188 801 3834182 YLR033W RSC58 SGTC_1865 st057639 52.2 µM -0.628458312671772 0.248833934089527 no 2556 0.264851873682197 819 688818 SGTC_1756 st041558 35.5 µM -0.629051380204725 0.248637238279396 no 2557 0.264657709635058 835 3955792 SGTC_861 0443-0273 110 µM -0.629287818343395 0.248558844688081 no 2558 0.264580322474957 813 6149169 SGTC_2701 st077767 14.721 µM -0.630076232589436 0.248297532714023 no 2559 0.264322354520612 792 5721188 SGTC_2408 sulbentine 18.36 µM -0.632501837487058 0.24749450969749 no 2560 0.263529504074702 801 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_941 3237-0776 460 µM -0.635087387298417 0.246640065505418 no 2561 0.262685711287127 813 760008 SGTC_3066 9117245 49.47 µM -0.635276001767293 0.246577796150595 no 2562 0.262624211195917 805 17176980 SGTC_1231 0242-0792 125 µM -0.635894488051352 0.246373667615284 no 2563 0.262422597761899 811 3707635 SGTC_2848 9016370 25.97 µM -0.638162343342408 0.245625948063457 no 2564 0.261684003601246 797 7894410 SGTC_3297 9117502 71.43 µM -0.639579895791892 0.245159195949611 no 2565 0.261222878073749 797 7453720 SGTC_1223 0764-0573 147 µM -0.640096983459885 0.244989055257086 no 2566 0.261054775008231 810 1609797 SGTC_1904 st060225 78 µM -0.640589606083063 0.244827023564138 no 2567 0.260894677172138 792 66595 SGTC_3344 9148862 3.898 µM -0.643985424326034 0.243711653961957 no 2568 0.259792442868861 832 4905352 SGTC_1206 3978-0017 132 µM -0.64447936652362 0.243549645584201 no 2569 0.259632316665936 807 3873677 SGTC_3158 9100007 49.47 µM -0.645156191811578 0.243327747772768 no 2570 0.259412986183825 807 19297233 SGTC_1233 0325-0408 14.2 µM -0.645796925826588 0.243117783237169 no 2571 0.259205439586383 815 12874 SGTC_475 α-linolenic acid 10 µM -0.646740880936703 0.242808633611819 no 2572 0.258899830035527 808 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2932 9016711 44.54 µM -0.646844213678051 0.242774804589626 no 2573 0.25886638693688 819 7117328 SGTC_230 MPP+ 141.667 µM -0.648051473240931 0.242379761615152 no 2574 0.258475829391225 822 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1964 st076914 61 µM -0.648222709846093 0.242323757294305 no 2575 0.258420457788429 840 24208661 SGTC_752 1896-0090 130 µM -0.648881529995395 0.242108350226017 no 2576 0.258207476968819 816 772567 SGTC_2714 st079313 56.9 µM -0.649506223174191 0.241904197206083 no 2577 0.258005612661049 817 2939799 SGTC_401 neomycin 50 µM -0.65002830068683 0.241733651192556 no 2578 0.25783697055033 791 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1996 st072960 66.8 µM -0.650116192331366 0.241704946224806 no 2579 0.257808585311587 803 1719405 SGTC_349 k015-0014 24 µM -0.650254853594657 0.241659663917916 no 2580 0.257763806957123 805 2196908 SGTC_182 3448-4371 550.524 µM -0.650562344799216 0.241559263616908 no 2581 0.25766452217822 778 3491403 SGTC_1284 0929-0043 16 µM -0.653029042341649 0.240754671651962 no 2582 0.256868777788727 810 1239883 SGTC_1768 st044301 37.178 µM -0.653648918115548 0.240552708962756 no 2583 0.256669010199023 849 3931349 SGTC_2367 9070478 135.38 µM -0.655209878646516 0.24004453886132 no 2584 0.256166317460441 806 572802 SGTC_3252 9135871 49.47 µM -0.655303861972691 0.240013961317551 no 2585 0.256136067403435 832 17682838 SGTC_509 pifithrin 175 µM -0.655877934339131 0.23982723256893 no 2586 0.255951333356173 830 4817 A p53 inhibitor. SGTC_1401 3807-4679 7.6 µM -0.656567028602449 0.23960319530167 no 2587 0.255729677594265 834 3291456 SGTC_363 0455-0021 3.06 µM -0.658808073380054 0.238875380802758 no 2588 0.255009511159013 817 4597466 SGTC_464 bw-b 70c 158 µM -0.65935047589071 0.238699408975667 no 2589 0.254835368110363 836 5353454 SGTC_3083 9117465 49.47 µM -0.659735112166451 0.238574664297324 no 2590 0.254711915018105 835 16420915 SGTC_2214 7179297 48.276 µM -0.662187283332234 0.23778021921009 no 2591 0.253925601512924 816 769744 SGTC_2157 5649910 96.377 µM -0.664059984099183 0.23717448727431 no 2592 0.253325960096995 827 2858091 SGTC_476 mead acid 10 µM -0.665261618198156 0.236786261238315 no 2593 0.25294158760967 830 5312531 An omega 9 fatty acid. SGTC_889 0919-1524 82.7 µM -0.666076157699128 0.236523297260357 no 2594 0.252681211583349 822 3905452 SGTC_2981 9013952 38.96 µM -0.6672491100388 0.236144906645141 no 2595 0.252306513302418 797 2996344 SGTC_2458 5808907 16.39 µM -0.667540992312233 0.236050798212018 no 2596 0.252213317383205 838 2731747 SGTC_2794 7785382 27.27 µM -0.668581009316752 0.235715644868174 no 2597 0.251881395040534 823 2205081 SGTC_2512 diallyl trisulfide 49.23 µM -0.670633019566202 0.23505513940575 no 2598 0.251227171044593 850 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2321 7390090 138.78 µM -0.671322712102842 0.234833369479523 no 2599 0.251007484505749 830 649046 SGTC_2957 9076800 11.52 µM -0.67272962212453 0.234381337805074 no 2600 0.250559659321952 833 16459615 SGTC_1165 k072-0275 30.3 µM -0.67291537149362 0.234321693660507 no 2601 0.250500566190596 828 6153523 YGL055W OLE1 SGTC_3324 9138759 60.749 µM -0.673304049606761 0.234196916256195 no 2602 0.250376938488048 839 45595710 SGTC_1929 genistein trimethyl ether 50.5 µM -0.674083947178341 0.233946656598131 no 2603 0.250128972338326 815 136420 SGTC_3349 9149703 23.001 µM -0.674160653827666 0.233922050371046 no 2604 0.250104590721833 820 4910494 SGTC_1379 2144-0755 36.5 µM -0.674225004934297 0.233901408704227 no 2605 0.250084137352836 837 5392327 SGTC_1317 1273-0028 910 nM -0.674443266032734 0.233831405414697 no 2606 0.250014771809677 824 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3211 9128781 49.47 µM -0.674692301183096 0.233751546089436 no 2607 0.249935638438585 816 17194361 SGTC_1759 st043059 70 µM -0.674704189660444 0.233747734131099 no 2608 0.249931861090319 843 669426 SGTC_2778 tioconazole 65.09 nM -0.675245963499992 0.233574054652134 no 2609 0.249759754425778 831 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3353 9151644 39.2805 µM -0.675328424052501 0.23354762608662 no 2610 0.249733564492859 815 4909158 SGTC_438 sphingosine 6.67 µM -0.67771032725332 0.232784943519544 no 2611 0.248977688586944 806 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1563 conessine 56.1 µM -0.678468990932141 0.232542311239137 no 2612 0.248737189274846 830 441082 An anti-amoebic, histamine inhibitor. SGTC_3109 9122853 49.47 µM -0.678626050199119 0.232492098850761 no 2613 0.248687416341549 865 1234709 SGTC_905 2-aminofluorene 215 µM -0.679250805274256 0.232292422206884 no 2614 0.248489480596741 826 1539 An established DNA mutagen. YPR165W RHO1 SGTC_967 1306-0166 352 µM -0.679627852744951 0.232171961048037 no 2615 0.248370064541349 833 4437607 SGTC_594 1487-1584 10.8 µM -0.680617209019356 0.23185604153073 no 2616 0.248056867467871 846 5013332 SGTC_2006 4011487 200 µM -0.682854689688479 0.231142456962545 no 2617 0.247349333801445 831 45595294 SGTC_3201 9113999 49.47 µM -0.685345802766945 0.230349426941649 no 2618 0.246562867665572 832 16649224 SGTC_2890 9046729 58.44 µM -0.686268757552557 0.230055996847596 no 2619 0.246271823251209 837 903329 SGTC_1531 st059297 52.4 µM -0.687769429210303 0.229579343126003 no 2620 0.245798995169589 837 7566702 SGTC_918 glabranin 770.725 nM -0.688157503759769 0.229456170301644 no 2621 0.245676800911619 817 124049 Also referred to as licorice root. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.689322923306924 0.229086494953524 no 2622 0.245310037742622 836 1377 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.689763975278955 0.228946678843292 no 2623 0.245171313361194 850 364106 SGTC_2733 amorolfine 100 µM -0.690227695160502 0.228799728522754 no 2624 0.245025504732119 855 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_204 PMA1.184 62.41 µM -0.69111888160339 0.228517465071943 no 2625 0.244745417720492 832 2252213 YGL008C PMA1 SGTC_2197 6588183 93.1375 µM -0.692500710357179 0.228080188649596 no 2626 0.244311469980024 821 884136 SGTC_3033 9090887 49.47 µM -0.692913310179346 0.227949713704222 no 2627 0.244181978105822 832 19325384 SGTC_3157 9099274 49.47 µM -0.692919911878822 0.227947626414085 no 2628 0.244179906504561 820 17217662 SGTC_515 4092-1064 102 µM -0.693427821211287 0.227787070588742 no 2629 0.244020553896305 862 717353 SGTC_1212 0520-0165 585 µM -0.694396918653756 0.227480904677201 no 2630 0.243716662792947 866 5403258 SGTC_1033 k072-0102 21.3 µM -0.695157303077761 0.227240839606566 no 2631 0.243478363369682 832 5965931 SGTC_929 2805-0021 398 µM -0.695626730794493 0.227092705356462 no 2632 0.243331310708455 866 3098024 SGTC_1082 camptothecin 424.86 nM -0.696242984454738 0.22689832087056 no 2633 0.243138336323339 841 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2372 9071633 200 µM -0.69653041781582 0.226807688059931 no 2634 0.243048357414908 826 21321366 SGTC_1493 4348-0038 111 µM -0.696655012093991 0.226768407631994 no 2635 0.243009359684689 857 800424 SGTC_2666 tannic acid 100 µM -0.696855695555156 0.22670514688884 no 2636 0.242946553327276 837 16134267 A thiamine antagonist. SGTC_3148 9097893 49.47 µM -0.697733024691324 0.226428706469309 no 2637 0.242672085525116 802 17174100 SGTC_1775 st081588 35.1725 µM -0.698514906321296 0.226182501407637 no 2638 0.242427619515592 838 1426443 YGL099W LSG1 SGTC_1180 1193-0155 285 µM -0.698760569786041 0.226105176198295 no 2639 0.242350837020106 839 2921347 SGTC_1554 st069299 38.7 µM -0.699350098418077 0.225919676699419 no 2640 0.242166632701609 805 24207999 SGTC_198 3454-2873 16.191 µM -0.700439312011927 0.225577174138939 no 2641 0.241826496413835 832 710957 SGTC_1985 st071382 65.5 µM -0.701015331942709 0.22539616387348 no 2642 0.241646723523835 843 6123237 SGTC_2813 7971799 71.43 µM -0.704802850721979 0.224208012475213 no 2643 0.240466467129624 836 2234054 SGTC_396 dithiazanine 1.25 µM -0.705030645515438 0.224136666405162 no 2644 0.240395582554632 828 10578 An antihelmenthic. SGTC_2334 9017922 200 µM -0.705578669090371 0.223965076474516 no 2645 0.240225096681685 845 3163164 SGTC_1043 0916-0009 19.3 µM -0.709160066696544 0.222845555766858 no 2646 0.239112575688148 850 3101130 SGTC_2479 5617353 43.85 µM -0.710194447367185 0.222522809768345 no 2647 0.238791781845896 848 2731746 SGTC_723 4182-0001 115 µM -0.710317202449718 0.222484525600926 no 2648 0.238753727283993 850 744821 YLR208W SEC13 SGTC_1091 telmisartan 47.6 µM -0.710345707643354 0.222475636098241 no 2649 0.238744891035727 852 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1136 pergolide 1.05886 µM -0.710921713890087 0.222296048762342 no 2650 0.238566374750615 840 47811 A dopamine receptor agonist. SGTC_877 0771-0151 33.1 µM -0.711269865022893 0.222187542251892 no 2651 0.238458510928133 831 6166523 SGTC_2279 7948423 32.93 µM -0.711807135599077 0.222020153164684 no 2652 0.238292106726874 813 1247112 SGTC_2965 9082772 38.63 µM -0.712211395036237 0.22189425178224 no 2653 0.238166940870408 784 16459634 SGTC_1673 st016611 27.3 µM -0.712837506668473 0.221699337897746 no 2654 0.237973156781855 850 5226799 SGTC_324 1315-0088 19.6 µM -0.715228858984091 0.220955790529429 no 2655 0.23723381968899 851 6787421 SGTC_2995 9067767 71.4286 µM -0.715859951315664 0.220759802212372 no 2656 0.237038914790714 829 11673567 SGTC_1572 epiandrosterone 68.9 µM -0.716179652612438 0.220660555664378 no 2657 0.236940212673363 835 441302 A steroid. SGTC_460 trequinsin 123 µM -0.716852556344859 0.220451746166402 no 2658 0.23673253939439 861 5537 A vasodilator. SGTC_2971 9092186 9.93 µM -0.717794011630805 0.220159792282151 no 2659 0.236442153137636 824 25236400 SGTC_2773 thioridazine 9.09 µM -0.718039248732472 0.220083778437605 no 2660 0.236366543419166 850 5452 An antipsychotic. SGTC_1307 1187-1599 12.2 µM -0.719424686123204 0.219654630270782 no 2661 0.235939645558692 853 1538471 SGTC_735 3076-0345 636 µM -0.720118340102117 0.219439947124076 no 2662 0.235726068181747 835 2888990 SGTC_1714 st033236 13.627 µM -0.721294688502209 0.219076147681516 no 2663 0.235364112114823 855 2916566 SGTC_646 4092-0839 27.3 µM -0.722138015969776 0.218815552420334 no 2664 0.235104813709232 854 877796 SGTC_3009 9080819 71.4286 µM -0.723044110833355 0.218535760381206 no 2665 0.234826392102874 840 17027216 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.724186573627116 0.218183274328993 no 2666 0.234475600116726 845 756377 SGTC_991 3996-0057 64.7 µM -0.724719292264077 0.218019025782944 no 2667 0.234312128588757 842 715343 SGTC_2375 9072683 200 µM -0.725369028669372 0.217818794680183 no 2668 0.234112834076557 854 16798029 SGTC_1628 st004252 77.7 µM -0.725616974891187 0.21774241236332 no 2669 0.234036805954957 840 692968 SGTC_2067 5224629 34.075 µM -0.728310520433624 0.216913634969047 no 2670 0.233211761863334 843 2835000 SGTC_11 0438-0307 1.3 µM -0.729438695357091 0.21656704921718 no 2671 0.232866677527466 858 4011476 SGTC_3051 9093778 49.47 µM -0.72946102453944 0.216560192721028 no 2672 0.232859850377081 874 17217378 SGTC_2453 5731132 22.18 µM -0.729536059020503 0.216537153226011 no 2673 0.232836909389512 859 1362040 SGTC_881 0833-0569 170 µM -0.729717999498085 0.216481293908923 no 2674 0.232781288254643 846 5418700 SGTC_1010 4112-3296 15.2 µM -0.730436441446508 0.216260799540363 no 2675 0.232561725082882 850 704384 SGTC_451 chloral hydrate 100 µM -0.731220188711253 0.216020410911706 no 2676 0.232322335316853 869 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2496 diffractaic acid 79.83 µM -0.732568128478779 0.215607337082373 no 2677 0.231910937977631 855 94870 An apoptosis inducer which activates caspases. SGTC_1238 0333-0287 48.8 µM -0.735167144957726 0.214812167215624 no 2678 0.231118852859896 839 7226 SGTC_673 1082-0474 110 µM -0.735434151225938 0.214730573187328 no 2679 0.231037564723798 858 3098046 SGTC_2356 9061756 188.97 µM -0.73779901454879 0.214008684819164 no 2680 0.230318296116317 838 20104043 SGTC_1741 st038134 10.228 µM -0.738016101031727 0.213942488763537 no 2681 0.230252332488462 845 1272587 SGTC_2224 6650123 117.647 µM -0.738366492272165 0.213835669316257 no 2682 0.23014588533725 852 2908370 SGTC_2692 st077426 47.7 µM -0.738416073327763 0.213820556661225 no 2683 0.23013082507794 846 25238571 SGTC_2989 9073649 71.4286 µM -0.73845995142129 0.213807182828003 no 2684 0.230117497554816 851 21367202 SGTC_3143 9086658 49.47 µM -0.742361560065909 0.212619939892522 no 2685 0.228934151485342 859 25236626 SGTC_880 0833-0487 87.2 µM -0.744859260095743 0.211861925878996 no 2686 0.228178402924831 854 76075 SGTC_2864 9034755 47.6 µM -0.745208031746114 0.21175620492404 no 2687 0.228072984091037 842 4930451 SGTC_765 1319-0117 244 µM -0.745635446300613 0.211626687548391 no 2688 0.227943832211213 831 3487746 YGL099W LSG1 SGTC_2664 lyso-paf C-16 73.48 µM -0.746082100079057 0.211491389765062 no 2689 0.2278089107881 854 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_721 1187-1332 279 µM -0.747366981467251 0.211102463448725 no 2690 0.227421035310292 864 25730 SGTC_657 3534-0529 86.7 µM -0.748769529316154 0.210678399058607 no 2691 0.226998064095322 865 1049549 SGTC_2426 5582046 32.21 µM -0.749584349110057 0.210432265621187 no 2692 0.226752539926789 847 2251934 SGTC_1264 0783-0040 158 µM -0.750033910590398 0.210296538419202 no 2693 0.226617140758611 855 2855798 SGTC_1617 st002906 78 µM -0.753191491551145 0.209344681949492 no 2694 0.225667425744431 867 5150859 SGTC_1287 0971-0001 34.6 µM -0.753423016687736 0.209274988340415 no 2695 0.225597877963951 836 4665869 SGTC_2475 5812728 15.03 µM -0.757219093190868 0.208134243723264 no 2696 0.224459306590808 850 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2299 7976368 114.88 µM -0.757522690752419 0.208043169522991 no 2697 0.224368388486845 858 2979718 SGTC_583 1488-1091 88.9 µM -0.758389097220986 0.207783391438316 no 2698 0.224109041457485 880 4303273 SGTC_1761 st044296 37 µM -0.759355211756223 0.20749394354239 no 2699 0.223820049063159 868 1826700 SGTC_2836 9010338 19.48 µM -0.759393621276753 0.207482440978553 no 2700 0.223808564060429 856 2994051 SGTC_404 fumagillin 50 µM -0.760407195075258 0.207179040545141 no 2701 0.223505611898303 851 12015870 A methionine aminopeptidase binder. SGTC_1828 st055811 49 µM -0.760803315104332 0.20706053840335 no 2702 0.223387277020089 867 5877589 SGTC_2641 levomentholum 100 µM -0.762962093602136 0.206415429494157 no 2703 0.22274300141796 851 16666 SGTC_2616 abietic acid 100 µM -0.763661504064284 0.206206679986968 no 2704 0.222534493547104 865 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2935 9038016 29.96 µM -0.768258105570046 0.204837872464205 no 2705 0.221166929459528 869 6463195 SGTC_3210 9128157 49.47 µM -0.768979082973676 0.204623666152529 no 2706 0.220952863972432 866 17590849 SGTC_2596 sinensetin 100 µM -0.771452567630952 0.203889793987517 no 2707 0.220219363396961 872 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3293 9120939 62.045 µM -0.773887539111407 0.203168882853787 no 2708 0.219498649543005 857 934087 SGTC_3055 9094636 49.47 µM -0.774774460700191 0.202906674456146 no 2709 0.219236471511412 871 25236176 SGTC_2855 9016525 58.44 µM -0.777061624405006 0.202231433572949 no 2710 0.218561206821149 864 43811474 SGTC_2010 4012422 159 µM -0.77808700841361 0.201929145693178 no 2711 0.218258860534608 874 952393 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.778253347193281 0.2018801337737 no 2712 0.218209836356677 849 17037758 SGTC_479 n-linoleoylglycine 10 µM -0.779960939525767 0.201377401620481 no 2713 0.217706933454885 870 6433346 An anti-infammatory. SGTC_636 0kpi-0074 126 µM -0.781069827407238 0.201051336238191 no 2714 0.21738071339031 869 616434 SGTC_2026 5148700 152 µM -0.78261436071867 0.20059769863952 no 2715 0.216926802919364 870 79838 SGTC_615 k087-0205 167 µM -0.782821628810845 0.200536869709612 no 2716 0.216865932287499 866 9642773 SGTC_12 0849-0099 9.267 µM -0.787776471656567 0.19908602481477 no 2717 0.215413732899511 865 6071388 SGTC_2477 5967686 25.23 µM -0.788437439812631 0.198892963618852 no 2718 0.215220439191296 875 776118 SGTC_2417 cerulenin 830 nM -0.788931071685507 0.198748853060665 no 2719 0.215076147039224 863 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1019 4262-0212 3.4 µM -0.789023584004554 0.198721852082909 no 2720 0.215049111272867 870 4677213 SGTC_1332 1480-0653 17.5 µM -0.791278683417433 0.198064354963508 no 2721 0.214390692398061 866 5749438 SGTC_1827 berberine 7.24 µM -0.792035325841919 0.197844042842918 no 2722 0.214170039287126 836 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1609 st001574 46.4 µM -0.792672130673691 0.197658738706284 no 2723 0.21398443582623 877 3960012 SGTC_3343 9148379 18.9835 µM -0.7929604117179 0.197574886174259 no 2724 0.213900444083109 838 1955036 SGTC_2662 daunorubicin 22.37 µM -0.794888163892461 0.197014712291037 no 2725 0.21333927994226 839 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3128 9127691 49.47 µM -0.794967266498707 0.196991746892591 no 2726 0.213316271705922 861 41316314 SGTC_2519 cryptotanshinone 88.04 µM -0.796742842108913 0.196476680878315 no 2727 0.212800198451322 858 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_147 4466-0538 29.23 µM -0.797312849211593 0.196311504161946 no 2728 0.212634679848861 863 6742687 YHR072W ERG7 SGTC_2152 5568786 200 µM -0.798822108059764 0.19587455769012 no 2729 0.212196784670733 872 5399883 SGTC_2480 5767542 37.17 µM -0.799395103890652 0.195708823985397 no 2730 0.212030674271898 855 2867358 SGTC_965 1291-5240 308 µM -0.799980034348764 0.195539726132183 no 2731 0.211861182510097 884 2834598 SGTC_1871 st057448 67.3 µM -0.80072532891824 0.195324397123452 no 2732 0.211645337892362 874 691747 SGTC_359 0081-0058 15.9 µM -0.80086058063272 0.195285335919564 no 2733 0.211606181472806 872 3494159 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.801168912561487 0.195196306243524 no 2734 0.211516932844919 868 66535 A nucleotide analog. SGTC_1419 3993-2473 62.6 µM -0.80119411449159 0.195189030372323 no 2735 0.211509638961268 878 704026 SGTC_2399 5884133 200 µM -0.801470187551729 0.19510933806173 no 2736 0.211429748185502 879 722445 SGTC_1772 st048439 82.2 µM -0.802373375194924 0.194848758664963 no 2737 0.2111685047921 859 2927068 YDL195W SEC31 SGTC_985 1493-0307 8.71 µM -0.802630511938476 0.194774610660301 no 2738 0.211094163629733 882 3278274 SGTC_90 0870-0863 4.608 µM -0.802851684322838 0.194710847078246 no 2739 0.211030232446175 885 1738164 SGTC_688 0527-0193 473 µM -0.803403355485229 0.194551856672236 no 2740 0.210870818109447 899 4007154 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.804022399195258 0.194373543748301 no 2741 0.21069201948836 904 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_411 enrofloxacin 100 µM -0.805429883311291 0.193968494352167 no 2742 0.210285826482224 851 71188 A bacterial gyrase inhibitor. SGTC_2300 7976697 71.57 µM -0.805540811371915 0.193936593070708 no 2743 0.210253832749445 858 2236109 SGTC_2913 7966556 36.57 µM -0.806464580779347 0.193671054752675 no 2744 0.209987511372708 843 2976516 SGTC_1312 1218-2183 165 µM -0.806546441022175 0.193647534652856 no 2745 0.209963920748953 861 6744073 SGTC_179 1273-0063 6.77 µM -0.807968955039337 0.19323909583913 no 2746 0.209554226985686 889 3108139 SGTC_1288 0973-0013 65.5 µM -0.811447524910016 0.19224252997679 no 2747 0.208554358148238 875 4315430 SGTC_2054 5233173 129 µM -0.811706885129402 0.192168352731432 no 2748 0.208479921337323 798 6889 SGTC_873 0591-4978 488 µM -0.814066548769944 0.191494291523143 no 2749 0.207803413966235 873 3305145 SGTC_1525 8-methoxypsoralen 92.5 µM -0.814914240534322 0.191252494107857 no 2750 0.20756070058659 885 4114 Related to psoralen; DNA damaging agent. SGTC_565 1418-0001 44.5 µM -0.815221257098944 0.191164966232706 no 2751 0.207472836122143 891 2862145 SGTC_592 k241-0073 46.5 µM -0.815465703775292 0.191095294078599 no 2752 0.207402894133632 869 4230158 SGTC_3099 9120367 49.47 µM -0.816884892082211 0.190691104945723 no 2753 0.206997106175476 881 24824940 SGTC_1134 3477-0009 42.5 µM -0.818696410472163 0.190175941991688 no 2754 0.206479822557123 855 3973534 SGTC_1376 2910-0861 41.3 µM -0.818945377379122 0.190105207221017 no 2755 0.206408789339489 889 1112859 SGTC_1200 1643-0193 18.4 µM -0.821457111282079 0.189392495264422 no 2756 0.20569297206455 887 5403974 SGTC_2869 9037858 32.47 µM -0.82205907277518 0.189221931509446 no 2757 0.205521638597146 872 27187042 SGTC_1353 1498-1206 8.11 µM -0.82316268281294 0.188909473072962 no 2758 0.205207743432368 847 6756808 SGTC_1838 st055369 84.5 µM -0.823831713462455 0.188720209332985 no 2759 0.205017592618192 862 676036 SGTC_1292 0kpi-0043 232 µM -0.823832477074827 0.188719993379585 no 2760 0.20501737564537 871 3333905 SGTC_121 0557-0495 61.343 µM -0.824014920188098 0.18866840191971 no 2761 0.204965540170802 895 3104427 SGTC_2337 9009472 200 µM -0.827232649705859 0.187759918315535 no 2762 0.204052604623728 854 5742383 SGTC_1900 st060200 72.8 µM -0.827534739861091 0.187674766097596 no 2763 0.203967020048029 883 688945 SGTC_305 1682-2595 20.8 µM -0.828596196248125 0.187375755354921 no 2764 0.203666470556861 878 226033 SGTC_2092 5303694 80.6725 µM -0.829274446722713 0.187184847464175 no 2765 0.203474563489928 878 1963699 SGTC_1022 4477-0945 21.3 µM -0.830287227786671 0.186900002891775 no 2766 0.20318820379676 856 4648966 SGTC_3195 9113082 49.47 µM -0.831179107481009 0.186649384047727 no 2767 0.202936227780279 864 17018038 SGTC_307 1501-1223 22.3 µM -0.834302189299273 0.185773436829229 no 2768 0.202055359234973 877 2830329 SGTC_2418 pentamidine 31.67 µM -0.834572301897251 0.1856977969191 no 2769 0.201979281350666 848 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2132 5317594 122.667 µM -0.837205714629963 0.184961361140197 no 2770 0.201238472920068 897 794577 SGTC_2947 9072639 7.68 µM -0.838314999584874 0.184651692767461 no 2771 0.200926906935113 922 16488146 SGTC_1143 3454-2408 5.08 µM -0.839033167540167 0.18445138076683 no 2772 0.200725348807576 847 X1143 SGTC_2841 9004761 38.96 µM -0.840351918006093 0.184083905949034 no 2773 0.200355549808324 871 2991039 SGTC_1452 4194-0072 190 µM -0.841395605614415 0.183793401754944 no 2774 0.20006317323392 905 1343545 SGTC_1311 1190-0148 100 µM -0.84200270321451 0.183624551218019 no 2775 0.199893220171058 902 1961333 SGTC_82 0054-0107 293.755 µM -0.843284955806113 0.18326823932295 no 2776 0.199534547288438 881 3104697 SGTC_2100 5377183 190 µM -0.843695838557993 0.183154154647245 no 2777 0.199419696782048 862 2844202 SGTC_1460 k062-0059 9.15 µM -0.843886052595627 0.183101355297754 no 2778 0.19936654137463 868 1373085 SGTC_3194 9111903 49.47 µM -0.845185913369341 0.182740795942297 no 2779 0.199003523028278 892 17087251 SGTC_3079 9117512 49.47 µM -0.845605430931724 0.182624523556696 no 2780 0.198886447422009 938 7185044 SGTC_1037 k284-1091 78.7 µM -0.847735118552808 0.182034977727568 no 2781 0.198292751823612 880 3334711 SGTC_1123 mangostin 811.285 nM -0.847824114761542 0.182010367488116 no 2782 0.198267965547985 833 5281650 An antioxidant. SGTC_1219 1469-0211 33.1 µM -0.848162660753741 0.181916767927209 no 2783 0.198173694414766 897 6822282 SGTC_2771 fluoxetine 41.05 µM -0.848910078897444 0.181710231982279 no 2784 0.197965665045664 873 3386 A selective serotonin reuptake inhibitor. SGTC_662 k832-1615 104 µM -0.84957680481411 0.181526117783013 no 2785 0.197780206146103 882 5878478 SGTC_3280 9140961 49.47 µM -0.850840233846228 0.181177546363422 no 2786 0.197429054228769 910 4901226 SGTC_1824 st053723 68.6 µM -0.853188310901835 0.180530842491967 no 2787 0.19677744226209 882 675225 SGTC_607 4491-0986 66.8 µM -0.854318693914065 0.1802200310197 no 2788 0.19646421602424 865 698981 YDR232W HEM1 SGTC_148 3253-0744 288.01 µM -0.854584492595407 0.180146995494009 no 2789 0.196390607790674 884 6893655 SGTC_1651 st011928 86.1 µM -0.855782263662831 0.179818105382067 no 2790 0.196059113757365 906 720198 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.857913389704568 0.179233863125585 no 2791 0.195470145026014 909 5377381 SGTC_719 2810-4230 27.3 µM -0.858071596141742 0.179190538927541 no 2792 0.195426465186724 886 721079 SGTC_112 phenothiazine 287.218 µM -0.858715697184812 0.179014222447349 no 2793 0.195248694001178 894 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2621 lithochol-11-enic acid 100 µM -0.860012259033885 0.17865963225143 no 2794 0.194891142456188 903 6708711 SGTC_2656 pseudo-anisatin 100 µM -0.860781636972026 0.178449428172999 no 2795 0.194679160253382 921 6708809 A neurotoxin. SGTC_1280 0880-0253 10.1 µM -0.862109437798682 0.178087022315242 no 2796 0.194313649178352 898 6836607 SGTC_3313 9133968 57.047 µM -0.862164519397737 0.178071998543773 no 2797 0.194298495594123 889 1494643 SGTC_2584 androsterone 48.74 µM -0.862200998812056 0.178062049047649 no 2798 0.194288460081926 836 2754130 A steroid. SGTC_1713 st033146 12.748 µM -0.863224260062128 0.177783104761621 no 2799 0.194007088816963 897 674619 SGTC_933 2914-0560 114 µM -0.866944491357576 0.176771282475236 no 2800 0.192986212211135 879 463887 SGTC_2810 7959871 45.46 µM -0.868680671511393 0.176300327468251 no 2801 0.192510908133522 880 2974535 SGTC_2318 6029776 164 µM -0.868751531474174 0.176281122923155 no 2802 0.19249152441992 890 818325 SGTC_1290 0986-0249 10.2 µM -0.869180759267135 0.176164821431975 no 2803 0.192374134839817 888 53329 SGTC_1646 st011709 75.6 µM -0.869584995898599 0.176055335843288 no 2804 0.192263620133698 894 5757843 SGTC_1294 1000-1494 117 µM -0.870137725156969 0.175905701464586 no 2805 0.19211257172618 885 712797 YDL207W GLE1 SGTC_2145 5634607 200 µM -0.873000449072143 0.175131996731165 no 2806 0.191331416474102 911 308662 SGTC_2897 9048598 12.99 µM -0.87458060393335 0.174705856311989 no 2807 0.190901072583465 899 6467404 SGTC_1046 2001-0062 216 µM -0.875093646068849 0.174567639410522 no 2808 0.190761477015202 901 739778 SGTC_2642 cholecalciferol 100 µM -0.876531186789078 0.174180726561809 no 2809 0.190370664926958 875 9821465 A vitamin D precursor, similar to steriods. SGTC_1650 st011916 45.8 µM -0.877532105902239 0.173911652149897 no 2810 0.19009884408695 906 242528 SGTC_171 k064-0041 9.68 µM -0.877918487745892 0.173807852900978 no 2811 0.189993977731965 885 53325 SGTC_3118 9124250 49.47 µM -0.878887986836711 0.173547576095908 no 2812 0.18973100643976 877 1504786 SGTC_1447 4239-0816 81.9 µM -0.878896297722917 0.173545345984641 no 2813 0.189728753125776 885 1341554 SGTC_2880 9042983 58.44 µM -0.881157254222858 0.172939327011603 no 2814 0.189116355927776 912 6464714 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.883180326853087 0.172398214101038 no 2815 0.188569424584103 887 1241132 A phosphatase inhibitor. SGTC_218 alverine citrate 93.75 µM -0.883645583394371 0.172273924457972 no 2816 0.188443782005862 888 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1778 st046819 58.9 µM -0.885344437776947 0.171820574477084 no 2817 0.187985444814453 908 671715 SGTC_2772 vinpocetine 57.06 µM -0.886003063770552 0.17164502112143 no 2818 0.187807938123515 911 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2806 7952793 58.44 µM -0.887471117373681 0.171254131551805 no 2819 0.187412654778613 902 2972490 SGTC_3104 9120930 49.47 µM -0.888347249186616 0.171021120752094 no 2820 0.187176995588371 882 17014836 SGTC_34 0469-0683 81.75 µM -0.888904373867812 0.170873056721706 no 2821 0.187027237296535 894 3690923 SGTC_3183 9108214 49.47 µM -0.889990016202461 0.170584767124351 no 2822 0.186735623473104 887 4974831 SGTC_304 1310-0298 97 µM -0.890184153999645 0.170533247160869 no 2823 0.186683505901508 903 1550234 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.892430061853606 0.169937956361151 no 2824 0.186081231985987 893 5024745 SGTC_138 0850-0259 40.9225 µM -0.893637476005776 0.169618475574384 no 2825 0.185757944141506 884 6813004 SGTC_507 nimesulide 162 µM -0.89842261908282 0.168356122952245 no 2826 0.184480141033766 890 4495 A COX2 inhibitor. SGTC_3249 9135183 49.47 µM -0.901150441627794 0.16763921621248 no 2827 0.183754168287157 881 4902779 SGTC_400 oxethazaine 37.5 µM -0.903386078122232 0.1670531305512 no 2828 0.183160513090877 900 4621 A local anesthetic. SGTC_2089 5281248 129.67 µM -0.903505056909518 0.167021976614588 no 2829 0.183128952799163 899 2737878 SGTC_2563 tomatine 8.54 µM -0.903702703196447 0.166970232310883 no 2830 0.183076532679328 907 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_393 acivicin 6.25 µM -0.903802489675622 0.166944111883262 no 2831 0.18305007067821 882 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_71 0417-1750 47.813 µM -0.903841215267926 0.16693397565839 no 2832 0.183039801826808 872 6811472 SGTC_1255 0566-0045 221 µM -0.904020599608561 0.1668870279068 no 2833 0.182992239234223 904 2788469 SGTC_483 fpl-64176 144 µM -0.906310034912626 0.166288594162837 no 2834 0.182385887779905 917 3423 SGTC_2293 7624732 200 µM -0.906336080273017 0.166281794168479 no 2835 0.182378996957963 890 894453 SGTC_987 1497-1013 404 µM -0.906376913493938 0.166271133680288 no 2836 0.182368194038639 896 1676435 SGTC_1937 st074714 47.2 µM -0.906465592940038 0.166247983311831 no 2837 0.182344734202435 914 17250970 SGTC_433 pimozide 108 µM -0.907958237742226 0.165858630755253 no 2838 0.181950143283038 902 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1669 st015249 58.4 µM -0.908902874687123 0.165612529428005 no 2839 0.18170069812316 918 722793 SGTC_2104 5389443 200 µM -0.909003005385777 0.165586456749961 no 2840 0.181674269700094 914 2244536 SGTC_85 0868-0259 160.055 µM -0.911024357034785 0.165060691905685 no 2841 0.181141270092823 871 83173 SGTC_1334 1486-0610 236 µM -0.912385628804105 0.164707227207302 no 2842 0.180782876027205 874 3742339 SGTC_189 3970-0742 2.116 µM -0.912748067787296 0.16461319985902 no 2843 0.180687528492407 886 2891807 SGTC_2250 alverine citrate 130 µM -0.91365672778952 0.164377619634744 no 2844 0.180448624171541 876 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_876 0720-0963 56.8 µM -0.914760180307233 0.164091831303878 no 2845 0.180158771691018 921 765861 SGTC_2037 5169046 200 µM -0.916016815813128 0.163766762160709 no 2846 0.179829037581802 893 5718022 SGTC_1931 st074438 57.1 µM -0.916325178735593 0.163687058097861 no 2847 0.179748182840538 922 2787313 SGTC_1250 0485-0349 40.2 µM -0.91756596869918 0.16336659966773 no 2848 0.179423070629599 916 6842794 YDL195W SEC31 SGTC_1659 st012954 42.1 µM -0.917990363764586 0.16325708488922 no 2849 0.179311955389277 905 24207262 SGTC_3070 9117005 49.47 µM -0.919410330329569 0.162891010634818 no 2850 0.178940494012038 928 8779016 SGTC_2690 usnic acid 100 µM -0.91969129621501 0.162818639571069 no 2851 0.178867051138368 909 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1386 3228-0095 33.8 µM -0.919809295202175 0.162788251682012 no 2852 0.17883621253675 913 870181 SGTC_2529 gangaleoidin 93.61 µM -0.9199906623912 0.162741551981409 no 2853 0.178788819414117 909 4565183 SGTC_1514 1189-1591 158 µM -0.92108431778852 0.162460134601622 no 2854 0.178503203553325 926 767698 YMR146C TIF34 SGTC_2750 bromebric acid 70.15 µM -0.921157340863792 0.162441355724515 no 2855 0.17848414330043 918 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1241 0364-0022 50.8 µM -0.921665606866653 0.162310687345578 no 2856 0.178351512828957 934 4563895 SGTC_3145 9085516 49.47 µM -0.923935428780509 0.161727981878215 no 2857 0.177759967867916 914 25236195 SGTC_1906 st060206 94.7 µM -0.924940908644309 0.161470292788356 no 2858 0.177498322853107 903 5133468 SGTC_3144 9087057 49.47 µM -0.926651562006712 0.161032494089058 no 2859 0.177053737181014 894 17249618 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.928310097318433 0.160608774015038 no 2860 0.176623368923242 890 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2622 2-methoxyxanthone 59.94 µM -0.929015444297589 0.160428793951007 no 2861 0.176440541248018 916 71034 A hepatoprotective. SGTC_2871 9038510 12.99 µM -0.931247890262585 0.159860020185408 no 2862 0.175862675201605 906 4945164 SGTC_1696 st025591 34.7925 µM -0.933586237939676 0.159265681325711 no 2863 0.175258683484549 899 2787147 SGTC_2359 9039622 200 µM -0.934361905162599 0.159068849685574 no 2864 0.175058620693565 918 6463596 SGTC_2009 4012297 12.05 µM -0.935879706047557 0.158684157040468 no 2865 0.174667563519616 909 45595307 SGTC_715 0868-0130 184 µM -0.937199423306176 0.158350165646053 no 2866 0.174327993192582 945 2876258 SGTC_2801 7907800 81.82 µM -0.941133257580441 0.157357337049674 no 2867 0.173318287115431 896 6620925 SGTC_2516 gossypol 71.55 µM -0.941607717185266 0.157237869153615 no 2868 0.173196758621795 928 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1726 st035556 14.5795 µM -0.943672453978761 0.156718667554379 no 2869 0.172668527289014 906 5919439 SGTC_3052 9092717 49.47 µM -0.946220359433049 0.15607952478546 no 2870 0.172018101965863 928 25237534 SGTC_1578 josamycin 24.2 µM -0.946609431504831 0.155982077342443 no 2871 0.171918918086971 907 5282165 A P450 substrate. SGTC_2016 5121758 140 µM -0.947348013849476 0.155797201490392 no 2872 0.171730736062032 906 2795203 SGTC_3345 9148410 3.559 µM -0.948817618598147 0.155429772045496 no 2873 0.171356689715985 886 4903596 SGTC_314 1671-0008 2.74 µM -0.949771707952371 0.155191537701153 no 2874 0.171114132260062 918 3913060 SGTC_810 3825-7150 143 µM -0.953457149216093 0.154273554870292 no 2875 0.170179248737821 880 22330411 YGL099W LSG1 SGTC_963 1269-2853 151 µM -0.954760809815525 0.153949695970386 no 2876 0.169849335098842 918 3668223 SGTC_2497 7-hydroxyflavone 100 µM -0.958099179183895 0.153122421665863 no 2877 0.169006374671946 916 5281894 SGTC_386 1509-0011 3.07 µM -0.958658499060156 0.152984106495323 no 2878 0.168865405954308 917 3107280 SGTC_936 3005-4620 401 µM -0.959032834174402 0.152891582806162 no 2879 0.168771102258232 908 777207 SGTC_546 peri-Naphthalide 147 µM -0.962222623663237 0.152104674094804 no 2880 0.167968893541006 892 223824 A penicillin ester. SGTC_92 0063-0024 660.874 µM -0.963139940440464 0.151878874438932 no 2881 0.167738650212213 942 3594437 SGTC_2715 st079500 56.4 µM -0.966361251088051 0.151087706294117 no 2882 0.166931723241035 907 28246688 SGTC_2064 5220758 200 µM -0.967469690502714 0.150816103960948 no 2883 0.166654643019704 917 788518 SGTC_635 k038-0028 24.7 µM -0.96855987732322 0.150549291331998 no 2884 0.166382415140091 931 4035102 SGTC_2786 7743617 45.45 µM -0.968664279659604 0.150523756381226 no 2885 0.166356360162148 914 583674 SGTC_340 k038-0059 454 µM -0.968756167944712 0.150501284531461 no 2886 0.166333430410525 917 23733424 SGTC_1735 st034310 56.75 µM -0.969100566010981 0.150417079734856 no 2887 0.166247507669348 887 871153 SGTC_982 1491-0518 27.5 µM -0.971117312952499 0.149924618378247 no 2888 0.165744931682123 920 3091256 SGTC_484 loperamide 105 µM -0.972515850877306 0.149583747038363 no 2889 0.165396991575241 893 3955 An opioid-receptor agonist. SGTC_1122 capsaicin 818.572 nM -0.973496492681095 0.149345039914488 no 2890 0.165153301260172 915 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_499 genistein 192 µM -0.977314305697271 0.148418134059211 no 2891 0.164206786448225 949 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2580 diallyl disulphide 81.36 µM -0.979402377834278 0.1479128135274 no 2892 0.163690601342412 916 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1100 amiodarone 5.07 µM -0.980684175879569 0.147603185236793 no 2893 0.163374254837954 908 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_526 4469-0568 170 µM -0.980979177073607 0.147531986905321 no 2894 0.163301505087069 924 2901964 SGTC_555 4296-0685 37 µM -0.980992725519652 0.147528717550053 no 2895 0.163298164433035 924 2908540 YHR072W ERG7 SGTC_63 0099-0242 26.702 µM -0.981221954314436 0.147473410049774 no 2896 0.163241649988038 920 3898502 YLR359W ADE13 SGTC_2401 5128683 200 µM -0.982206193123047 0.147236094341483 no 2897 0.162999138577424 945 708373 SGTC_1720 st037298 9.481 µM -0.982409804458281 0.147187032367406 no 2898 0.16294899903726 952 597396 SGTC_2925 9010536 32.5 µM -0.982496528000968 0.147166138881839 no 2899 0.162927646304198 867 2994177 SGTC_1987 st072290 61.9 µM -0.983315344416594 0.146968967174986 no 2900 0.162726130194289 925 54697379 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.983617989672062 0.146896134796735 no 2901 0.162651688256004 929 97141 SGTC_1632 st005650 90 µM -0.983794310612661 0.146853713860238 no 2902 0.162608328642978 932 2759605 SGTC_1274 0865-0114 173 µM -0.984371806591963 0.146714832028631 no 2903 0.162466367523535 907 870624 SGTC_2892 9047358 58.44 µM -0.98471135265989 0.146633215852175 no 2904 0.162382937350003 934 6466771 SGTC_25 0118-0223 35.662 µM -0.986899854106495 0.146107900207391 no 2905 0.161845867889682 919 5333628 SGTC_1952 st077036 64.1 µM -0.987704755137988 0.145915014634637 no 2906 0.161648632502674 924 2937007 SGTC_1600 coumarin 106 71.1 µM -0.994773205727582 0.144228490069177 no 2907 0.15992329035829 933 100336 A hepatotoxic, DNA x-linker. SGTC_871 0574-0004 149 µM -0.994916653009884 0.14419440030918 no 2908 0.159888401384326 936 9551173 SGTC_119 0121-0043 24.815 µM -0.995185986660731 0.144130408756547 no 2909 0.159822908018595 934 1092378 SGTC_2774 tamoxifen 10.92 µM -0.995936366084022 0.143952225521541 no 2910 0.159640532214662 919 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2907 7721985 69.9 µM -0.996162476683913 0.143898563002915 no 2911 0.159585603925479 929 3267881 SGTC_136 0097-0015 404.482 µM -0.996195109649178 0.143890819380449 no 2912 0.159577677530279 935 4861337 SGTC_2777 climbazole 1.536 µM -0.996383847468772 0.143846038452442 no 2913 0.159531839048203 934 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1363 1636-0063 10.4 µM -0.997613732536906 0.143554459714052 no 2914 0.159233349721354 910 6072185 SGTC_1587 estradiol valerate 56.1 µM -0.99799145828792 0.143464989368256 no 2915 0.159141750308392 944 13791 A steroid. SGTC_3295 9122362 53.5725 µM -1.00266148027895 0.142361930418926 no 2916 0.158012110616119 979 4730473 SGTC_927 2425-1185 123 µM -1.00334909475941 0.142200001810566 no 2917 0.157846228068041 933 730375 SGTC_704 1310-0270 142 µM -1.00701642039162 0.141338476747617 no 2918 0.156963441685114 926 5718033 SGTC_3193 9111931 49.47 µM -1.00716143906852 0.141304481953668 no 2919 0.156928600159125 957 17087244 SGTC_3059 1327-0034 3 µM -1.00720892108094 0.141293352583429 no 2920 0.15691719345314 922 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1365 1672-3266 55.4 µM -1.00781058572398 0.141152379098927 no 2921 0.156772701512174 908 6415873 SGTC_2681 menadione 3.18 µM -1.00785028101055 0.141143081619925 no 2922 0.156763171625461 942 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_470 aa-861 153 µM -1.00887441734468 0.140903350700772 no 2923 0.156517432848506 920 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1266 0828-0227 32.9 µM -1.01027145808883 0.140576775551214 no 2924 0.156182625852533 945 3913820 SGTC_1860 st056228 74.6 µM -1.01040603877389 0.140545342843233 no 2925 0.156150397931759 944 688679 SGTC_794 k038-0031 316 µM -1.01095033354476 0.140418265851547 no 2926 0.15602010083178 911 6624242 SGTC_586 0957-0265 8.15 µM -1.01248786710828 0.140059718055287 no 2927 0.155652422473523 904 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1910 st062352 60.4 µM -1.01371209773901 0.13977467667889 no 2928 0.155360074860334 937 2245730 SGTC_447 ml7 120 µM -1.01456275462104 0.139576847990225 no 2929 0.155157150568776 951 4216 Selective myosin light chain kinase inhibitor. SGTC_3321 9137793 26.8275 µM -1.01764307904985 0.138862081674383 no 2930 0.154423803474606 925 4904192 SGTC_2514 salinomycin 42.74 µM -1.01808520440194 0.138759694701699 no 2931 0.154318733011166 943 23682228 A polyether potassium ionophore. SGTC_399 oxolinic acid 75 µM -1.01895750761676 0.138557838374351 no 2932 0.154111570061812 917 4628 A DNA gyrase inhibitor. SGTC_946 3434-1334 87.4 µM -1.01896491297732 0.138556125585293 no 2933 0.154109812153522 913 4047976 SGTC_3274 9138298 49.47 µM -1.02012597503311 0.138287761469197 no 2934 0.153834359586465 960 17015756 SGTC_1902 st060212 70.5 µM -1.02024934756028 0.138259266383472 no 2935 0.15380510961819 908 688944 SGTC_2663 amphotericin b 100 µM -1.0220915302559 0.137834257535897 no 2936 0.153368790745516 936 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1015 4130-4525 82 µM -1.02365034854411 0.137475320457669 no 2937 0.153000227510594 934 1363237 SGTC_2123 5259487 200 µM -1.0243680934369 0.137310265621192 no 2938 0.152830723221838 934 2173474 SGTC_2122 5258151 111.688 µM -1.02499639343597 0.137165890939828 no 2939 0.152682444705037 943 2173356 SGTC_1257 0669-0121 16 µM -1.02582997708285 0.136974505012138 no 2940 0.152485866681004 920 4307855 SGTC_661 1304-0007 33.6 µM -1.02590480325592 0.136957334290443 no 2941 0.152468229182244 935 3117130 SGTC_165 k038-0023 64.381 µM -1.02787163140936 0.136506524222017 no 2942 0.152005107783559 955 46368543 SGTC_2030 5175110 200 µM -1.02926603545287 0.136187533047984 no 2943 0.151677339487939 960 2831986 SGTC_284 0988-0104 32.6 µM -1.02929140075004 0.136181735077923 no 2944 0.151671381480435 939 4666532 SGTC_1515 3460-0031 42.1 µM -1.02995558052355 0.136029977760686 no 2945 0.151515428889353 926 2876596 SGTC_698 k064-0052 127 µM -1.0302124354719 0.135971320460305 no 2946 0.151455146714191 986 5088751 SGTC_726 3448-4391 34.2 µM -1.03098503221272 0.13579498893143 no 2947 0.15127391945397 946 1356692 SGTC_1746 st038117 42 µM -1.03244317591465 0.13546262030181 no 2948 0.150932277269562 926 2898218 SGTC_2921 7974240 10.71 µM -1.03302261411733 0.135330698322506 no 2949 0.15079665794599 934 2979074 YDR527W RBA50 SGTC_862 0452-0056 10.2 µM -1.03490256950213 0.134903291189496 no 2950 0.150357207271268 943 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2713 st079149 53.4 µM -1.03534755873882 0.134802258736946 no 2951 0.150253313430821 924 3103253 SGTC_3327 9140648 26.9345 µM -1.03578259562277 0.134703536111873 no 2952 0.150151789476784 942 8029710 SGTC_3351 9150312 21.596 µM -1.03792226413141 0.134218704777832 no 2953 0.149653123645838 935 4904905 SGTC_1431 4049-0260 9.09 µM -1.03926853953544 0.133914264865802 no 2954 0.149339931036401 951 3854841 SGTC_3101 9120531 49.47 µM -1.03988630084406 0.133774726412287 no 2955 0.149196363865923 959 24824904 SGTC_1524 corynanthine 62.1 µM -1.04034149909742 0.13367197129394 no 2956 0.149090635200647 966 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_954 1189-0853 2.85 µM -1.0450248169655 0.132617923974654 no 2957 0.148005749900373 927 2828194 SGTC_811 0416-0114 265 µM -1.04712006262314 0.13214821784275 no 2958 0.147522103629659 908 6612453 SGTC_829 1635-0120 117 µM -1.04787299405092 0.131979708334187 no 2959 0.147348563105815 929 285054 SGTC_1787 fluconazole 80 µM -1.04836621819712 0.131869402877678 no 2960 0.147234955797071 907 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2612 dictamnine 15.46 µM -1.05031523697131 0.131434143393302 no 2961 0.146786601019289 913 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2724 maprotiline 69.64 µM -1.05151650212457 0.131166368598115 no 2962 0.146510717163326 927 4011 A tricyclic antidepressant. SGTC_2231 micatex 6.853 µM -1.05895769767968 0.129516044556654 no 2963 0.144809522769393 966 20737 An antifungal of unknown mechanism. SGTC_510 ag-490 170 µM -1.05895921945486 0.129515708532075 no 2964 0.144809176229559 953 5328779 SGTC_544 k015-0020 52.4 µM -1.05974711971835 0.129341812655552 no 2965 0.144629829958262 941 3008304 SGTC_1777 st045864 34.765 µM -1.06473824175614 0.128243991515986 no 2966 0.143497199705319 970 4691462 SGTC_3006 9075424 71.4286 µM -1.06896571661246 0.127319213082631 no 2967 0.142542558918708 945 7465181 SGTC_3012 9080433 71.4286 µM -1.0690068658746 0.12731023435775 no 2968 0.142533287822579 943 17688859 SGTC_1463 k081-0032 34.1 µM -1.07022614469106 0.127044388886996 no 2969 0.14225876440413 900 977755 SGTC_6 0844-0013 19.835 µM -1.07305377660413 0.12642935373424 no 2970 0.141623494296931 964 1584900 SGTC_2258 7960471 200 µM -1.0748166608022 0.126046962160023 no 2971 0.141228409840689 971 2974708 SGTC_943 3253-1379 105 µM -1.07814038673909 0.125328199545362 no 2972 0.140485555311872 938 668464 SGTC_1666 st014829 29 µM -1.07837739531451 0.125277055462827 no 2973 0.140432685280015 958 3858230 SGTC_1911 st060208 74.3 µM -1.0792838911457 0.125081577174349 no 2974 0.140230595889785 963 688783 SGTC_1973 st070275 50.2 µM -1.07965794358068 0.125000977997743 no 2975 0.140147264215108 947 17118334 SGTC_1624 st003710 6.25 µM -1.08006512467411 0.124913281651453 no 2976 0.140056590362156 956 24207033 SGTC_1946 st076057 65.1 µM -1.0815737050119 0.124588746874653 no 2977 0.139720996900146 927 953009 SGTC_1355 1499-0035 1.68 µM -1.0845909875912 0.12394142056811 no 2978 0.139051424201889 970 1548538 SGTC_2364 9055074 200 µM -1.08494774846199 0.123865037166532 no 2979 0.138972399150811 953 6470630 SGTC_254 nsc-64875 3.808 µM -1.08500285915046 0.123853240767979 no 2980 0.13896019447133 955 56993 SGTC_1421 4029-0249 71.4 µM -1.08852863084185 0.123100186103913 no 2981 0.138180902109748 948 2894095 SGTC_226 1,3-diallylurea 8.28947 mM -1.08890495592931 0.123019998385436 no 2982 0.138097900275748 942 74537 YKL182W FAS1 SGTC_160 3453-0671 289.699 µM -1.08951442673689 0.122890209435811 no 2983 0.137963548218719 983 5322268 SGTC_1710 st031758 61.5 µM -1.09422075232455 0.121891213839662 no 2984 0.136929085994891 946 5394341 SGTC_3226 9131256 49.47 µM -1.09493769685481 0.12173953261806 no 2985 0.136771966268134 916 17178073 SGTC_2291 7917025 104.35 µM -1.09696253046069 0.121311862679649 no 2986 0.136328885984156 944 2964612 SGTC_696 1560-0013 611 µM -1.09729933301699 0.121240828413561 no 2987 0.13625528118722 950 1650269 SGTC_651 3253-0966 34.4 µM -1.09891715879456 0.120900024181114 no 2988 0.135902100762849 951 781462 SGTC_2682 pyrogallin 40.03 µM -1.10072571189599 0.120519840844947 no 2989 0.13550802613047 951 822798 An ATP competetive kinase inhibitor. SGTC_2449 5812982 45.77 µM -1.10213710980965 0.120223730560743 no 2990 0.135201034087544 964 776185 SGTC_391 gliotoxin 8.33 µM -1.10224536584167 0.120201039706231 no 2991 0.135177507108835 961 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1966 st070145 16.1 µM -1.1034919041059 0.119939978195428 no 2992 0.134906802704236 960 3748532 SGTC_951 1171-0579 82.7 µM -1.10436145513744 0.119758105631939 no 2993 0.134718187036728 940 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2560 caryophyllene 100 µM -1.10554494186017 0.119510883854333 no 2994 0.134461765965052 967 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_831 k061-1017 217 µM -1.10731462960663 0.119141881004921 no 2995 0.13407896068365 983 1240153 SGTC_2260 7964312 200 µM -1.10901141809346 0.118788834572162 no 2996 0.13371262815526 965 231951 SGTC_3348 9149464 3.537 µM -1.10946023140664 0.118695574847432 no 2997 0.133615845632402 949 1951442 SGTC_3296 9122258 64.045 µM -1.11030862152517 0.118519427674412 no 2998 0.133433029605603 958 4730474 SGTC_2895 9054447 58.44 µM -1.11356530227386 0.117844974619856 no 2999 0.132732859405798 981 2697450 SGTC_1221 2958-7315 257 µM -1.11406332198078 0.117742075464784 no 3000 0.132626011118063 964 4562705 SGTC_2868 9035608 32.47 µM -1.11443529938976 0.117665260239813 no 3001 0.13254624340464 957 6462614 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.11586706856788 0.117369923675868 no 3002 0.132239519947028 922 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_556 4058-0063 51.5 µM -1.11621673833238 0.11729787576984 no 3003 0.132164685681005 961 6615692 SGTC_177 1327-0068 8.361 µM -1.11689326784214 0.117158568805216 no 3004 0.132019981720759 952 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2168 5727979 200 µM -1.116906945981 0.117155753492919 no 3005 0.132017057209438 964 695210 SGTC_2978 9011784 42.97 µM -1.11952175146593 0.116618439425264 no 3006 0.131458808341596 928 2994934 SGTC_531 3788-1495 174 µM -1.12255046093391 0.115998259721235 no 3007 0.130814232507551 936 2896655 SGTC_580 1123-0028 41 µM -1.12539315686814 0.115418302893151 no 3008 0.130211234799778 994 1677248 YPR107C YTH1 SGTC_1445 4239-0156 97.7 µM -1.12823945222593 0.114839679232912 no 3009 0.129609403231663 986 4008346 SGTC_3080 9117754 49.47 µM -1.12827571657892 0.114832320386551 no 3010 0.129601747809885 957 9550191 SGTC_1670 st016595 4.04 µM -1.12870140463516 0.11474596386146 no 3011 0.129511908280789 966 597879 SGTC_1799 st045822 46.1415 µM -1.13245354289282 0.113986790480403 no 3012 0.128721902647324 918 3674992 SGTC_2942 9052777 62.25 µM -1.1343760262833 0.113599202222209 no 3013 0.12831842542516 978 6469503 SGTC_278 4092-0821 23.9 µM -1.13636225563627 0.113199750074581 no 3014 0.127902492797667 976 877900 SGTC_2041 5107442 45.335 µM -1.13751125434559 0.112969132086047 no 3015 0.127662311259843 954 793005 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.13996586662691 0.112477585473662 no 3016 0.127150260948652 958 5357218 A potent inhibitor of glutathione S-transferases. SGTC_664 1222-0054 14.9 µM -1.14126934191999 0.112217180949019 no 3017 0.126878928041288 958 6813991 SGTC_2270 7924575 90.91 µM -1.14192786503108 0.112085787057859 no 3018 0.126742002483589 954 1262135 SGTC_2002 4023503 131 µM -1.14200326529329 0.112070749604013 no 3019 0.126726331206635 979 4736863 YCR052W RSC6 SGTC_1052 3253-3998 198 µM -1.14327660032939 0.111817019796604 no 3020 0.126461883578189 966 5450317 SGTC_2867 9039098 71.43 µM -1.14449897445205 0.111573831431252 no 3021 0.126208381480012 950 6463460 SGTC_1519 esterone 74 µM -1.14733832319801 0.11101041092212 no 3022 0.125620910536367 970 698 A steroid. SGTC_43 0570-0105 72.5 µM -1.14866177808667 0.110748491218196 no 3023 0.125347736150298 957 1114046 YDL195W SEC31 SGTC_10 0279-0212 42.575 µM -1.15233868713339 0.110023133673251 no 3024 0.124590962649924 981 39851 YBR002C RER2 SGTC_2695 st077686 51.995 µM -1.15233949216148 0.110022975236477 no 3025 0.124590797311248 966 2876092 SGTC_3326 9140064 16.379 µM -1.15236653658244 0.110017652746113 no 3026 0.124585242949795 985 1868434 SGTC_2640 pentamidine 10.38 µM -1.15319802546754 0.109854101319507 no 3027 0.124414556898144 924 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.15332071438285 0.109829983550572 no 3028 0.124389385461437 970 16486 A toxic proline analog. SGTC_1999 st074831 12.5 µM -1.15436646969055 0.109624566771182 no 3029 0.124174977909908 963 17112523 SGTC_1476 4112-3294 3.34 µM -1.16009701606202 0.10850381734866 no 3030 0.123004654468202 931 704369 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.16087538659123 0.108352225986014 no 3031 0.122846289858117 974 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_208 k072-0098 12.366 µM -1.16179651468545 0.108173028877159 no 3032 0.122659065065913 974 5948901 SGTC_3132 9126706 49.47 µM -1.1628741685482 0.107963652008581 no 3033 0.122440279659849 950 850858 SGTC_2305 7443522 69.23 µM -1.16375386179112 0.107792953282474 no 3034 0.122261887372236 942 5415886 SGTC_3165 9101544 49.47 µM -1.16415650802239 0.107714887299826 no 3035 0.122180295963498 976 5002184 SGTC_885 0865-0106 16.8 µM -1.16526150377309 0.107500857453197 no 3036 0.121956578323912 960 2793380 SGTC_823 0417-1665 178 µM -1.16609231183449 0.107340137789941 no 3037 0.12178856236884 986 3429856 SGTC_3063 1327-0034 4 µM -1.17844723351624 0.104970494177899 no 3038 0.119309178381067 948 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_327 1273-0057 3.96 µM -1.18029839382913 0.104618733782455 no 3039 0.118940778374053 949 3108138 SGTC_3042 9091578 49.47 µM -1.1843400633507 0.103853698241395 no 3040 0.11813923788132 951 25236497 SGTC_2121 5257820 149.641 µM -1.18720605962646 0.103313666696846 no 3041 0.117573175640641 966 791256 SGTC_413 propylparaben 100 µM -1.18835282181113 0.103098157606347 no 3042 0.117347217616478 957 7175 A pharmaceutical preservative. SGTC_2187 6125751 200 µM -1.1918829624011 0.102436794108265 no 3043 0.116653569801308 987 874498 SGTC_1546 5-methoxyflavanone 78.7 µM -1.19323014518897 0.102185217589647 no 3044 0.116389625843679 976 147795 SGTC_2440 5628896 157.78 µM -1.19697063689639 0.101489065199833 no 3045 0.115658999918533 979 5522048 SGTC_1374 2889-5571 141 µM -1.19751210465434 0.101388578157255 no 3046 0.115553506185913 947 2853281 SGTC_1510 1123-0200 71.5 µM -1.19826095157107 0.101249724593071 no 3047 0.115407721615205 977 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2531 methyl deoxycholate 70.07 µM -1.19843747632565 0.101217013005214 no 3048 0.115373375044931 998 16667744 Haematoxylin. SGTC_1457 k015-0032 57.3 µM -1.20030004712735 0.100872331484887 no 3049 0.115011415742696 976 4302660 SGTC_2046 4110841 106 µM -1.20148080605144 0.100654267635725 no 3050 0.114782373775216 958 44119630 YMR134W ERG29 SGTC_3257 9139206 32.98 µM -1.20213908325944 0.100532845664257 no 3051 0.114654823062202 974 4910041 SGTC_2206 7254556 146.969 µM -1.20249948853964 0.10046641269627 no 3052 0.114585032079542 967 4398905 SGTC_1853 st056710 91.2 µM -1.20326203242114 0.100325959710735 no 3053 0.114437468302067 975 269167 SGTC_1194 1488-0194 225 µM -1.20447445700681 0.100102938331178 no 3054 0.114203124437709 966 1391452 SGTC_1482 3346-2049 8.48 µM -1.20798775799248 0.0994587230984802 no 3055 0.113525985630487 972 3826804 SGTC_2421 5690543 90.72 µM -1.21318560715774 0.0985111873673873 no 3056 0.112529432824435 986 3397993 SGTC_1850 st056238 17 µM -1.21514550537705 0.0981556312769222 no 3057 0.112155300192412 961 5393177 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.2153930610517 0.0981107877782094 no 3058 0.112108106641149 956 6708514 SGTC_2317 5986382 200 µM -1.21924211553756 0.0974154803776395 no 3059 0.111376155680627 1006 877883 SGTC_2644 guaiazulene 100 µM -1.219561870192 0.0973578817421316 no 3060 0.111315504151 962 3515 A coloring agent. SGTC_1044 1222-0021 1.78 µM -1.21964310403119 0.0973432527589687 no 3061 0.11130009936481 945 4306703 SGTC_137 0438-0332 85.389 µM -1.22042975939042 0.0972016714667434 no 3062 0.111151000848994 979 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1300 1094-0077 113 µM -1.22325119305852 0.0966951161296358 no 3063 0.110617417663161 981 5532636 SGTC_287 k060-0039 29.6 µM -1.22582172352092 0.0962352978517707 no 3064 0.110132885216885 974 5861974 SGTC_2575 plumbagin 510 nM -1.2273243726927 0.0959672484020286 no 3065 0.109850349284451 962 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_260 nsc-65238 3.989 µM -1.22957508519016 0.0955667836958123 no 3066 0.109428132319619 985 3246252 SGTC_3277 9138724 49.47 µM -1.22971805673069 0.0955413866631105 no 3067 0.109401351345467 991 15943418 SGTC_14 0354-0009 295 µM -1.23055111450418 0.0953935035795021 no 3068 0.109245399242482 981 1713507 SGTC_114 0364-0001 490.298 µM -1.23184241723925 0.095164606715009 no 3069 0.109003977439275 1007 4003655 SGTC_743 1275-0778 158 µM -1.23783587205894 0.0941074983454567 no 3070 0.107888462188872 973 2849257 YMR203W TOM40 SGTC_1548 st061468 90.8 µM -1.2405901050971 0.0936246303188008 no 3071 0.107378604566795 982 390799 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.24495897425844 0.0928624431547581 no 3072 0.106573415509972 1005 688798 SGTC_2142 5622915 118.518 µM -1.24627332869304 0.0926340427856688 no 3073 0.1063320330593 982 5322196 SGTC_684 1140-0066 328 µM -1.24729682307956 0.0924564742421571 no 3074 0.106144340950947 988 6813534 SGTC_707 0865-0008 204 µM -1.24807039045518 0.0923224333466303 no 3075 0.106002640254665 997 723043 SGTC_2066 5222451 176 µM -1.25022717082043 0.091949473967623 no 3076 0.105608287015261 939 2281147 SGTC_2471 5466956 24.79 µM -1.25044421400737 0.0919120038425634 no 3077 0.105568660909084 963 724419 SGTC_40 0327-0103 19.753 µM -1.2514952076487 0.0917307212732023 no 3078 0.105376930511722 957 409036 SGTC_1614 st002383 48.6 µM -1.25471694039082 0.0911766654500397 no 3079 0.1047907669246 964 1947235 SGTC_1534 6-azauridine 81.6 µM -1.25567254034583 0.091012804809446 no 3080 0.104617359489985 985 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3056 9094900 49.47 µM -1.25734692323015 0.0907262183741683 no 3081 0.1043140198413 988 25236784 SGTC_1113 artemisinin 1.17947 µM -1.25771015752045 0.0906641358942962 no 3082 0.104248298709868 968 2240 An anti-malaria and mitochondrial poison. SGTC_2188 6126565 140.678 µM -1.25925653251734 0.0904001887990416 no 3083 0.103968844033632 973 874518 SGTC_2124 5246320 200 µM -1.26161807708876 0.0899982040310137 no 3084 0.103543124112771 972 579342 SGTC_1691 st019933 84.6 µM -1.26168241593337 0.0899872708175303 no 3085 0.103531543361359 1009 6176082 SGTC_986 1493-0483 84 µM -1.26924996937341 0.0887081777000324 no 3086 0.10217596203817 993 40079 SGTC_2528 xanthyletin 44.79 µM -1.27070265683892 0.0884641963818651 no 3087 0.101917225026418 999 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1328 1441-0025 69.2 µM -1.27110014676039 0.0883975244749657 no 3088 0.101846511571609 982 4562601 SGTC_589 1227-0070 34.1 µM -1.2740626482915 0.0879017962327126 no 3089 0.101320607254827 990 2841384 SGTC_1074 carmofur 3.8 µM -1.27417756100022 0.0878826092459095 no 3090 0.101300247844435 990 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1278 0874-0585 172 µM -1.27425773335581 0.0878692247093709 no 3091 0.10128604524619 999 766306 SGTC_3067 9117431 49.47 µM -1.27841142968966 0.0871778555737854 no 3092 0.100552198043182 1017 17150885 SGTC_2945 9067681 61.76 µM -1.2789458985253 0.0870891907745581 no 3093 0.100458054061118 1002 16456930 SGTC_1516 st013856 110 µM -1.27937084498372 0.0870187430781768 no 3094 0.10038324780029 997 5281404 A mutagen and neurotoxin. SGTC_3255 9139072 49.47 µM -1.27938938414748 0.0870156706217255 no 3095 0.100379985148876 984 17646060 SGTC_709 3807-1509 243 µM -1.27978351536291 0.0869503712588078 no 3096 0.100310641496128 1016 1886677 YPL242C IQG1 SGTC_690 glyoxal 20.3 µM -1.28072034875988 0.0867953043339853 no 3097 0.100145954867594 985 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_578 3460-0051 92 µM -1.28414048085959 0.0862309498903598 no 3098 0.0995464030823135 1009 2876744 SGTC_3122 9126309 49.47 µM -1.28535260703629 0.086031597633781 no 3099 0.099334547265711 1020 17591206 SGTC_1596 piperlongumine 63 µM -1.28580401519744 0.0859574450057792 no 3100 0.0992557342924027 975 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_8 0354-0001 70 µM -1.28708716876966 0.0857469231205902 no 3101 0.0990319536188261 988 4993152 SGTC_1832 st054113 55 µM -1.28772855758068 0.0856418378094758 no 3102 0.0989202345040493 983 1251267 SGTC_1150 3909-7983 10.9 µM -1.29070673220077 0.0851551559646551 no 3103 0.0984026946722936 997 23965914 SGTC_712 r015-0009 80.6 µM -1.29207612534974 0.0849320718060808 no 3104 0.0981653914905321 999 6813872 YLR060W FRS1 SGTC_392 N-ethylmaleimide 8.33 µM -1.29493068352573 0.0844684523435067 no 3105 0.0976720712578591 977 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1114 scopoletin 1.73284 µM -1.29705218532011 0.0841251231131353 no 3106 0.0973066158730179 1007 5280460 A coumarin with genotoxic properties. SGTC_1512 0259-0544 12.2 µM -1.29757560692147 0.0840405775062577 no 3107 0.0972166044069903 969 18476 SGTC_1552 6-methylflavone 10.6 µM -1.29930492738605 0.0837617027919714 no 3108 0.0969196520226469 994 689013 SGTC_2018 5133068 143 µM -1.30051288528234 0.0835673171169385 no 3109 0.0967126214554107 988 785362 SGTC_806 3966-4455 5.86 µM -1.30222341400285 0.0832926374170305 no 3110 0.0964200117036808 986 714982 SGTC_538 2922-0838 53.3 µM -1.30396831422113 0.0830131381898076 no 3111 0.0961221930396507 1016 777039 SGTC_3221 9128209 49.47 µM -1.3050785866251 0.0828356616473846 no 3112 0.095933044721454 989 16460723 SGTC_3340 9146634 11.102 µM -1.30907884130261 0.082198589609991 no 3113 0.095253822830917 981 4907387 SGTC_760 0568-0725 82.9 µM -1.31196015964561 0.0817420083306254 no 3114 0.0947667886726541 996 3916171 SGTC_1477 0139-0234 16 µM -1.31535000135265 0.0812072958035834 no 3115 0.0941961504152632 1001 620880 SGTC_1057 3448-5381 134 µM -1.31593294978454 0.0811156082617532 no 3116 0.0940982741618546 944 5497911 SGTC_2928 9011484 9.79 µM -1.31969844384669 0.0805252433492894 no 3117 0.0934678599053906 957 2994751 SGTC_295 k015-0027 31 µM -1.3217732646215 0.0802013370071914 no 3118 0.0931218317805829 1001 3887424 SGTC_3015 9080845 49.47 µM -1.32979655005201 0.0789580610551445 no 3119 0.0917926564715429 1006 5296973 SGTC_902 1120-0002 2.07 µM -1.33380868528605 0.0783418483134398 no 3120 0.0911332819207417 938 3280475 SGTC_58 0957-0393 9 µM -1.33564219481639 0.0780614616401348 no 3121 0.0908331257940796 1000 6997992 SGTC_846 0335-0850 148 µM -1.33763350326363 0.0777578069288036 no 3122 0.0905079686974301 984 6819598 SGTC_1051 3253-3903 78 µM -1.34373625995529 0.0768327812133284 no 3123 0.089516843765293 984 5509239 SGTC_1179 1021-1431 9.29 µM -1.35348723147434 0.0753721739001102 no 3124 0.0879500132275593 1008 2840958 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.35394129219498 0.0753046790033982 no 3125 0.0878775542005344 1014 6708784 An antioxidant flavonoid SGTC_2425 5628681 7.85 µM -1.35657005291651 0.0749148260417028 no 3126 0.0874589312881388 1006 5714958 SGTC_2508 celastrol 40.54 µM -1.35796966627319 0.0747078882969713 no 3127 0.0872366547879326 960 122724 Celastrol is a natural product and antioxidant. SGTC_1972 st070201 17.4 µM -1.35917803050295 0.0745295785223824 no 3128 0.0870450906042609 1012 2829099 SGTC_1556 plumbagin 1.48 µM -1.35930869177809 0.0745103172402093 no 3129 0.0870243954723643 958 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_188 3229-0966 278.469 µM -1.3603287515423 0.0743600769055827 no 3130 0.0868629569308006 989 5722370 SGTC_1244 0416-0015 52.5 µM -1.36116601205979 0.0742369332455348 no 3131 0.0867306161793589 1001 96201 SGTC_365 0121-0052 13.6 µM -1.36494288741383 0.0736833683935298 no 3132 0.0861355006336913 965 3101739 SGTC_744 1594-0068 283 µM -1.36793007444264 0.0732477849351295 no 3133 0.0856669824602976 1017 668392 SGTC_120 rhodamine 6G 52.259 µM -1.36955671419219 0.0730114226486972 no 3134 0.0854126597468463 1010 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.37035899089711 0.0728950613222585 no 3135 0.0852874334095425 963 279621 SGTC_2166 5933061 31.504 µM -1.37366122698096 0.072417602960234 no 3136 0.08477343965362 1010 2877375 SGTC_2593 nobiletin 86.24 µM -1.37389780836286 0.0723834887087658 no 3137 0.084736705069955 989 72344 An anti-infammatory. SGTC_2752 diclazuril 33.15 µM -1.3747870581566 0.0722553719490466 no 3138 0.0845987357814915 977 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_714 4296-0578 26.1 µM -1.37666919926666 0.0719847797498043 no 3139 0.0843072728151438 998 1589775 SGTC_2618 avocadyne 43.43 µM -1.37670013137417 0.0719803391921642 no 3140 0.0843024890598938 1019 3015189 SGTC_2980 9014342 25.29 µM -1.37811961218486 0.0717767869724265 no 3141 0.0840831806459094 968 2996599 SGTC_2566 crystal violet carbinol 226 nM -1.37918922461422 0.0716236974577115 no 3142 0.0839182097362376 997 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_666 0272-0154 136 µM -1.38513449811227 0.0707773354781471 no 3143 0.0830056724786713 1027 6870312 SGTC_2001 4023502 57.655 µM -1.38680936473193 0.0705402962768546 no 3144 0.0827499503837468 987 108941 YCR052W RSC6 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.3881340329661 0.0703532522251123 no 3145 0.0825481175105289 1004 4213774 SGTC_532 1548-0774 215 µM -1.38851558306512 0.0702994478961396 no 3146 0.0824900514841232 1027 5932993 SGTC_859 0439-0102 54.6 µM -1.39598567826112 0.0692524143893665 no 3147 0.0813594039788672 997 610143 SGTC_3134 9127454 49.47 µM -1.39788634467552 0.0689879375259371 no 3148 0.0810735999540547 1028 24262820 SGTC_2059 5238311 157 µM -1.40137786280418 0.0685041238510489 no 3149 0.0805505542463421 1003 703021 SGTC_2336 9001819 198.65 µM -1.40304916212531 0.0682734630494151 no 3150 0.0803010896887211 983 2989602 SGTC_2383 9036125 200 µM -1.40867057585805 0.0675020324606617 no 3151 0.079466299658886 1016 79580 SGTC_2909 7941780 10.49 µM -1.41626103972097 0.0664710974765996 no 3152 0.0783495451363004 982 1243215 SGTC_288 1315-0019 35.1 µM -1.41813810557012 0.0662180444210627 no 3153 0.0780752240087229 994 6811474 SGTC_1357 1503-1303 39.5 µM -1.4190135222471 0.0661002822233055 no 3154 0.0779475369004795 1001 292895 SGTC_1684 st024538 14.6195 µM -1.41977935067184 0.0659973950860339 no 3155 0.0778359641860451 1020 6732859 SGTC_944 3370-0224 231 µM -1.42083546809577 0.0658557119539369 no 3156 0.0776822984650158 998 4580514 SGTC_1423 4048-0112 5.59 µM -1.42249501570899 0.0656335522119528 no 3157 0.0774412987198681 1003 X1423 SGTC_1633 st005664 67.9 µM -1.42266507425452 0.0656108197353583 no 3158 0.0774166349036519 1031 2063822 SGTC_844 0330-0132 15.3 µM -1.42720653394802 0.0650059984106555 no 3159 0.0767601858503897 1010 2828079 SGTC_2702 st077768 96.8 µM -1.42858341293093 0.0648234862658258 no 3160 0.0765620021993035 986 6484119 SGTC_2256 7954252 200 µM -1.4312194615851 0.0644751752226391 no 3161 0.0761836637883664 1036 2972920 SGTC_2727 riluzole 51.77 µM -1.4315979628885 0.064425282022019 no 3162 0.0761294564909112 1019 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1248 0469-0687 58.6 µM -1.43498867470614 0.0639796630119126 no 3163 0.0756451624440673 1005 4017482 SGTC_2029 5175081 200 µM -1.43624338952657 0.0638153729542159 no 3164 0.0754665481978024 1008 1380876 SGTC_2090 5301565 104.445 µM -1.43769532476713 0.0636256689869239 no 3165 0.0752602601076133 1011 2056344 SGTC_1643 st009866 20.2 µM -1.43850635896359 0.0635198937182235 no 3166 0.0751452172539605 984 3156273 YOR207C RET1 SGTC_783 0848-0141 92.7 µM -1.43862727707659 0.0635041352790159 no 3167 0.0751280768618998 1014 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_257 daunorubicin 18.5 µM -1.44038177258231 0.0632758259551388 no 3168 0.0748797088415415 986 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1473 k844-0725 134 µM -1.44166504761918 0.0631092407281374 no 3169 0.0746984442096409 1011 54682906 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.44330912467716 0.0628963181970805 no 3170 0.0744667052559755 997 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_854 0422-0053 192 µM -1.44349072792336 0.0628728333352491 no 3171 0.0744411412809151 1021 3596728 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.44379845917398 0.0628330532466605 no 3172 0.0743978377813121 1046 4620898 SGTC_1812 st052057 4.327 µM -1.44429610434625 0.0627687646926102 no 3173 0.0743278505707156 1019 3645418 SGTC_737 1950-0117 57.9 µM -1.45669819699495 0.0611830934844364 no 3174 0.0725998538545818 1014 5393513 SGTC_1809 st050081 57.6 µM -1.45943774581563 0.0608370855098417 no 3175 0.0722223317069769 1019 5036894 SGTC_2757 clomiphene 4.22 µM -1.46192952839822 0.0605237011942683 no 3176 0.0718802611419885 1028 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_3121 9125696 49.47 µM -1.46419947937723 0.0602393166585749 no 3177 0.0715697262230202 1053 1235365 SGTC_332 4112-0506 40.9 µM -1.46445221027244 0.0602077187858863 no 3178 0.0715352157912921 1024 2790355 SGTC_3316 9136639 10.545 µM -1.46649066846298 0.0599533331492803 no 3179 0.0712573307777364 993 4903665 SGTC_3209 9113616 49.47 µM -1.47268362727963 0.0591856555006186 no 3180 0.0704181816977903 1018 16649353 SGTC_2731 amoxapine 43.43 µM -1.47451350094727 0.0589603064194406 no 3181 0.0701716926712201 1057 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1661 st013063 9.66 µM -1.47540538808126 0.0588507147380947 no 3182 0.0700517938276002 1021 721395 SGTC_1358 1509-0022 2.48 µM -1.47599168167476 0.058778760343129 no 3183 0.069973062662351 1014 3258434 SGTC_2396 5342950 42.78 µM -1.47981180704516 0.0583116148555767 no 3184 0.0694617384147472 985 1886677 SGTC_2289 7946404 165.07 µM -1.48228949211994 0.0580101926183598 no 3185 0.0691316415224422 993 1246120 YPR165W RHO1 SGTC_1316 1272-0050 65.9 µM -1.49009350247052 0.0570687948552931 no 3186 0.0680998262000116 1022 7340392 SGTC_1323 1348-1351 11.2 µM -1.49345146292322 0.0566674431905215 no 3187 0.067659525222449 1010 6989654 SGTC_2179 6298986 200 µM -1.49480259889638 0.0565065808339721 no 3188 0.0674829839393682 972 738374 SGTC_3218 9131285 49.47 µM -1.49653177148639 0.0563012357322801 no 3189 0.0672575674493387 1016 17156417 SGTC_1417 3966-0327 90.4 µM -1.49755500460178 0.0561800006597886 no 3190 0.0671244522808013 1028 651118 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.50504783484565 0.0552984942699077 no 3191 0.0661558895049152 1033 140250 A respiratory chain inhibitor. SGTC_1182 1222-0449 220 µM -1.50774689907917 0.0549836477391295 no 3192 0.0658096586545376 1021 658318 SGTC_2371 9071574 200 µM -1.51099339128272 0.0546068220929372 no 3193 0.0653950673274691 1046 45596039 SGTC_3074 9116018 49.47 µM -1.52409014348882 0.0531073565953052 no 3194 0.063743097274894 1050 17027303 SGTC_758 0868-0029 16 µM -1.53165127280981 0.0522566510932231 no 3195 0.0628042563703392 1001 762687 SGTC_190 3970-0790 3.722 µM -1.5322845662381 0.0521858929886844 no 3196 0.0627261139938319 1025 2832352 SGTC_759 3486-0358 89.3 µM -1.54190415781425 0.0511204221716999 no 3197 0.0615484427222136 1041 875103 SGTC_1125 tnp00248 1.32998 µM -1.54689994102487 0.0505739562446806 no 3198 0.0609436876481281 1017 24207736 SGTC_358 0075-0058 9.45 µM -1.54885394312772 0.0503614869811243 no 3199 0.0607084173439343 1037 1069125 SGTC_1912 st060209 90.8 µM -1.55102353495307 0.0501264094943813 no 3200 0.0604480220013986 1028 688787 SGTC_1409 3909-8004 61.9 µM -1.55233733821283 0.0499844833693007 no 3201 0.0602907641315558 1025 2119279 SGTC_1608 st001473 40.5 µM -1.55510805986475 0.0496862213967239 no 3202 0.0599601678638838 1020 7292267 SGTC_3224 9130643 49.47 µM -1.55607685456811 0.0495822685108742 no 3203 0.0598449090332078 1016 17644395 SGTC_69 0096-0274 206.684 µM -1.55672543779581 0.049512771763801 no 3204 0.0597678432363132 1036 6741392 SGTC_1829 berberine 14.4 µM -1.56020285418856 0.0491414858396736 no 3205 0.0593559756848234 978 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1550 gossypolone 36.6 µM -1.5662421647996 0.0485019524549925 no 3206 0.0586459674979125 1032 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_814 3342-0569 96 µM -1.56899232557168 0.0482129377592884 no 3207 0.0583248636245186 1029 4346283 SGTC_610 4215-0184 155 µM -1.57010730755345 0.0480961574350796 no 3208 0.0581950744041016 986 5605015 SGTC_1707 st032323 6.317 µM -1.57357778044877 0.0477341173020828 no 3209 0.057792546726787 1010 3132057 YMR211W DML1 SGTC_125 0133-0007 11.75 µM -1.58028432192856 0.0470406753292179 no 3210 0.0570208843240532 1029 26541 SGTC_320 4092-0846 5.34 µM -1.59069444807721 0.0459803142961886 no 3211 0.0558391785005587 1026 1359356 SGTC_463 ikarugamyin 104 µM -1.60079687190237 0.0449697394413932 no 3212 0.0547109583366327 1063 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_325 2810-4341 181 µM -1.60224963133693 0.0448258972919904 no 3213 0.0545502094677036 1016 774970 SGTC_1354 1498-1681 81 µM -1.60474311063972 0.044579874060677 no 3214 0.0542751751470029 1046 5754243 SGTC_158 k038-0087 26.446 µM -1.60887678724025 0.044174415322844 no 3215 0.0538216430718786 1012 X158 SGTC_3276 9139060 49.47 µM -1.61349480727461 0.0437249701982034 no 3216 0.0533185252522679 1041 4870619 SGTC_2419 paclitaxel 166.5 µM -1.61382762215005 0.043692722306373 no 3217 0.0532824106737076 1024 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_294 k038-0071 157 µM -1.61774078991832 0.0433149958301083 no 3218 0.0528592357223347 1045 24152826 SGTC_469 w7 172 µM -1.61844166059939 0.0432476221006847 no 3219 0.0527837249530581 1045 45115570 A P450 inhibitor. SGTC_237 nikkomycin 200 µM -1.63515660753021 0.0416657627895262 no 3220 0.0510081109736753 1053 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_916 4466-0038 42 nM -1.63584237799381 0.0416018776416153 no 3221 0.0509362900984739 1044 5722064 YGL116W CDC20 SGTC_2537 larixol 68.93 µM -1.64490487076408 0.0407650624729837 no 3222 0.0499947151593025 1030 6708759 SGTC_448 monastrol 171 µM -1.65870197320776 0.0395173364192254 no 3223 0.0485879307967479 1046 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3309 9129340 25.759 µM -1.66058930418322 0.0393490988289925 no 3224 0.0483979792862183 1034 17158987 SGTC_2088 5278280 127.392 µM -1.66486085141899 0.0389704827373148 no 3225 0.0479702601069236 1043 791502 SGTC_1121 fusaric acid 630.51 nM -1.6678966853765 0.0387032037259164 no 3226 0.0476681188956631 1038 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1936 st074407 74.3 µM -1.67036275860644 0.0384871882076418 no 3227 0.0474238066056464 1041 809813 SGTC_734 2023-0417 80 µM -1.67692629733882 0.0379170403099669 no 3228 0.0467784475262479 1043 3935732 SGTC_2511 berberine 10.47 µM -1.67801572333102 0.037823076557198 no 3229 0.0466720147810599 1031 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1743 st037606 46.3785 µM -1.68005093613158 0.037648047174801 no 3230 0.0464737028932594 1028 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_64 000l-0018 272.079 µM -1.6836428783929 0.0373407518900722 no 3231 0.0461253533901219 1016 6811119 SGTC_93 0109-0045 59.227 µM -1.6863261972772 0.0371125300667156 no 3232 0.0458664939352356 1048 88733 SGTC_1093 fluphenazine 7.97 µM -1.68765169669876 0.0370002149516996 no 3233 0.0457390546142296 1066 6602611 An atypical antipsychotic. SGTC_903 1134-0042 114 µM -1.69656112433477 0.0362524727511042 no 3234 0.0448898324267713 1033 701009 SGTC_2796 7949634 45.45 µM -1.69724620651971 0.0361954917180762 no 3235 0.0448250613415691 1027 2971588 SGTC_645 0845-0943 5.41 µM -1.69737950556372 0.0361844132283946 no 3236 0.0448124673346685 1036 1885106 SGTC_3312 9133330 71.43 µM -1.69748764178064 0.0361754280622085 no 3237 0.0448022527885 1054 17617324 SGTC_1152 3909-8331 15.9 µM -1.70004869368546 0.0359631606650913 no 3238 0.0445608833518957 1022 16001939 SGTC_3032 9089427 49.47 µM -1.70766599593502 0.0353378397652275 no 3239 0.0438491675389423 993 17173707 SGTC_1845 st056753 3.01 µM -1.70858240052316 0.0352632147260281 no 3240 0.0437641654907245 1028 5375839 SGTC_579 4491-1009 110 µM -1.71024317582051 0.0351283032144327 no 3241 0.0436104573727105 1057 1271041 SGTC_3021 9087658 49.47 µM -1.71729510899486 0.0345601551795449 no 3242 0.0429626326235114 1040 25237042 SGTC_2601 securinine 100 µM -1.7194357746389 0.0343891907286677 no 3243 0.0427675264183604 1025 442872 A GABA receptor antagonist. SGTC_1416 3966-0321 25.3 µM -1.72155057336198 0.0342209751775248 no 3244 0.0425754816772063 1051 582530 YLR208W SEC13 SGTC_2552 juarezic acid 87.02 µM -1.72483926957625 0.0339607295693669 no 3245 0.0422782212947362 1038 1549512 SGTC_2244 6635614 200 µM -1.72601960756283 0.0338677233010692 no 3246 0.0421719426558889 1055 836499 SGTC_157 1348-1695 65.819 µM -1.7300564865038 0.0335512146503171 no 3247 0.0418100917725698 1019 5380510 SGTC_191 3914-0123 66.505 µM -1.73050088672833 0.033516521019223 no 3248 0.041770411471115 1059 3144412 SGTC_761 k216-0224 480 µM -1.73106063880684 0.0334728640800404 no 3249 0.0417204748593108 1066 1340404 SGTC_2611 pyromycin 23.93 µM -1.73962248120918 0.0328109122634847 no 3250 0.0409626645328985 1052 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_824 1304-0008 100 µM -1.74508370711583 0.0323943468637389 no 3251 0.0404851496093762 1048 768245 SGTC_310 1273-0058 1.06 µM -1.74777737562749 0.0321904947485024 no 3252 0.040251292199257 970 2734232 SGTC_488 nitrendipine 139 µM -1.75618891829528 0.031560729724565 no 3253 0.0395280781302297 1068 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1462 k081-0014 26.5 µM -1.75807693804599 0.0314207836584711 no 3254 0.0393672095884058 955 3270634 SGTC_1439 4092-1168 46 µM -1.76199718445115 0.0311318407884117 no 3255 0.0390348865939475 1064 2886240 SGTC_1703 st026983 48.3 µM -1.7623510564149 0.0311058670726991 no 3256 0.0390050012609215 1041 1104023 SGTC_225 nsc-122657 1.016 µM -1.76989852362105 0.030556148640938 no 3257 0.0383720234128858 1044 275685 SGTC_919 tnp00227 403.569 nM -1.78026531013714 0.0298142249404274 no 3258 0.0375162757357288 1044 1269246 A methoxyflavone. YNL221C POP1 SGTC_1340 1486-1359 257 µM -1.78459689031133 0.0295086828433289 no 3259 0.0371633630962884 1040 4309068 SGTC_229 benomyl 22.8748 µM -1.7895303277079 0.0291638575628818 no 3260 0.036764723881282 1044 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_36 0335-0881 14.2 µM -1.79421551741533 0.028839489189878 no 3261 0.0363893881571112 1017 23828853 SGTC_1788 fluconazole 20 µM -1.8114073684112 0.0276748388301574 no 3262 0.0350389081104696 1045 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_972 1319-0219 195 µM -1.81318324667817 0.0275567988485129 no 3263 0.0349017814532572 1058 23903702 SGTC_3092 9117248 49.47 µM -1.81817665472183 0.0272271417253715 no 3264 0.0345185684643204 1076 17141857 SGTC_1352 1496-0991 99 µM -1.81888273881218 0.0271807937158266 no 3265 0.034464660904513 1056 3000039 SGTC_1492 4158-0558 28.5 µM -1.82906089848902 0.0265199714101853 no 3266 0.0336952428864326 1043 3967268 SGTC_529 4076-0302 30.3 µM -1.83071897291063 0.0264136020652338 no 3267 0.0335712498546785 1053 5816522 SGTC_2823 7987624 58.44 µM -1.83727339128393 0.0259966052233028 no 3268 0.0330847729823459 1045 2239440 SGTC_224 benfluorex 43.875 µM -1.83987502570246 0.0258326210553321 no 3269 0.0328932936788467 1069 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_527 4476-4215 268 µM -1.84105817257495 0.025758332705755 no 3270 0.0328065171687874 1044 4418754 SGTC_1615 st002656 86.5 µM -1.86095225728589 0.0245357494336451 no 3271 0.031375459557311 1066 1584458 SGTC_2906 7926292 26.41 µM -1.86861343978645 0.0240781047032706 no 3272 0.0308383072859601 1050 2966319 SGTC_13 0199-0087 65 µM -1.87202809420151 0.0238764510431498 no 3273 0.0306013584192864 1071 4589825 SGTC_2510 benzyl isothiocyanate 8.31 µM -1.89343980248769 0.0226440775697132 no 3274 0.029149703247106 1035 2346 DNA damaging agent; causes G2/M arrest. SGTC_201 4262-0159 12.803 µM -1.90196406986044 0.0221686006056413 no 3275 0.0285879260173703 1076 1341029 SGTC_348 k064-0012 10.7 µM -1.91879822503334 0.0212543268285895 no 3276 0.027504937293539 1051 5066323 SGTC_2939 9044578 71.43 µM -1.92958647529919 0.0206853392374626 no 3277 0.0268290479601431 1063 2653634 SGTC_2734 clemastine 41.6 µM -1.93824852697747 0.0202378767368901 no 3278 0.0262964544595402 1085 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2589 lobaric acid 100 µM -1.94096729221629 0.0200991345553523 no 3279 0.0261311223897057 1053 73157 A novel microtubule depolymerizer. SGTC_2333 9017922 200 µM -1.95434903632715 0.0194279473735087 no 3280 0.0253299766934305 1049 3163164 SGTC_344 k064-0035 6.43 µM -1.96546774025133 0.0188848422223827 no 3281 0.0246800629418227 1031 5088750 SGTC_2349 9023730 187.07 µM -1.97598218910526 0.0183831885206688 no 3282 0.0240783972398351 1067 4126287 SGTC_2997 9067075 71.4286 µM -1.98338806296404 0.0180366997974919 no 3283 0.0236620497316397 1043 27209819 SGTC_103 0844-0104 51.839 µM -2.01663784563043 0.0165488948356451 no 3284 0.0218666602640176 1035 5375804 SGTC_1652 st011932 78 µM -2.0187349701366 0.016458684763534 no 3285 0.0217573866221728 1056 1551076 SGTC_3302 9125395 16.351 µM -2.02237886702516 0.0163029397583295 no 3286 0.0215686132883463 1056 17599668 SGTC_1857 st056007 79.3 µM -2.02878336019256 0.0160322613333524 no 3287 0.0212401804306408 1074 619834 SGTC_869 0564-0080 44.1 µM -2.03446822364783 0.0157952332398788 no 3288 0.0209522046486007 1069 6843321 SGTC_915 methyl methanesulfonate (MMS) 110 mM -2.03848017133209 0.0156297712635652 no 3289 0.0207509678920535 1068 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_638 3970-0837 4.09 µM -2.0489412197934 0.0152053121247948 no 3290 0.0202339315241585 1064 4118451 YLR208W SEC13 SGTC_821 1114-0266 29.2 µM -2.08103058538662 0.0139645041434653 no 3291 0.0187155533098024 1064 3123235 SGTC_142 0335-0849 62.6745 µM -2.08527443703248 0.0138071282281025 no 3292 0.0185221982236159 1059 3889043 YPR107C YTH1 SGTC_2798 7813637 45.45 µM -2.0874094982886 0.0137285331807911 no 3293 0.0184255670577445 1063 956368 SGTC_1698 5-fluorocytosine 1.055 µM -2.09110242683757 0.0135935014917463 no 3294 0.0182594416108186 1064 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1185 1319-0113 81.3 µM -2.10152923400199 0.0132184157643055 no 3295 0.0177972672639845 1075 4672763 SGTC_1325 1431-0015 227 µM -2.1065907176744 0.0130395847177049 no 3296 0.017576536020374 1077 1103340 SGTC_2281 7943571 200 µM -2.10717904727435 0.0130189343109481 no 3297 0.0175510312145684 1074 1244024 SGTC_573 3702-0553 84.7 µM -2.11513574190772 0.0127424184628904 no 3298 0.0172091898582566 1071 1222756 SGTC_1222 0366-0074 1.18 µM -2.12125889989389 0.01253309661144 no 3299 0.0169500105267017 1079 286520 SGTC_1970 st070122 35.8 µM -2.13140836054101 0.0121926893502321 no 3300 0.0165277573529588 1072 102928 SGTC_1641 st009299 47.1 µM -2.13490651514966 0.0120772345917862 no 3301 0.0163843235244481 1082 4046054 SGTC_1742 st038235 28.8875 µM -2.14559846764766 0.0117302088768339 no 3302 0.0159525139059013 1063 564103 YBR002C RER2 SGTC_1913 st060213 96.1 µM -2.17044673521523 0.0109569710999096 no 3303 0.0149865098000781 1072 688959 SGTC_851 0394-0702 453 µM -2.19565081948424 0.0102183496472806 no 3304 0.0140584729080032 1071 762646 SGTC_2833 9001315 45.46 µM -2.20235815673554 0.010029256969408 no 3305 0.0138200095637518 1059 2989378 SGTC_1145 3546-0597 10.2 µM -2.21975129683465 0.00955307243402252 no 3306 0.0132178273131111 1077 875334 SGTC_793 0488-0545 106 µM -2.22458506965184 0.00942429526658879 no 3307 0.0130545529252466 1078 292548 SGTC_173 1273-0061 2.693 µM -2.24452050515496 0.00890910105224707 no 3308 0.0123994655558763 1042 2847414 YPL266W DIM1 SGTC_2534 helenine 20.12 µM -2.24941061750781 0.00878655882627276 no 3309 0.0122431918581853 1060 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_897 1000-0139 31.4 µM -2.27261411515863 0.00822502147814646 no 3310 0.0115247221396162 1079 6151020 SGTC_3126 9127922 49.47 µM -2.27273101827047 0.00822227408374095 no 3311 0.0115211971176803 1053 45595682 SGTC_802 4112-3352 742 µM -2.2819280320591 0.00800864154787189 no 3312 0.0112467947677785 1078 704594 SGTC_1133 3473-0247 50 µM -2.28634247002232 0.00790784542631643 no 3313 0.0111171155595475 1049 711311 SGTC_2154 5570129 200 µM -2.28774750514725 0.00787599877960609 no 3314 0.0110761147419228 1088 673366 SGTC_1725 st036284 20.55 µM -2.30053117426543 0.00759138720633724 no 3315 0.0107090726163945 1063 707914 SGTC_200 k038-0079 37.545 µM -2.34149914455827 0.00673937744383224 no 3316 0.00960323498651578 1085 3436683 SGTC_839 0122-0028 230 µM -2.34779994195239 0.00661612661472967 no 3317 0.0094423307086558 1077 759448 SGTC_1675 st018485 24.5 µM -2.40173972194523 0.00563997264724473 no 3318 0.00815865691131159 1076 3323024 SGTC_2338 7999974 200 µM -2.40366823409035 0.00560757372679468 no 3319 0.00811574827669549 1060 315925 SGTC_3022 9087993 49.47 µM -2.4100749476008 0.00550112465147141 no 3320 0.00797462187676896 1091 17173644 SGTC_3310 9130229 44.1445 µM -2.41501762143352 0.00542023181073541 no 3321 0.00786722422564269 1079 7761258 SGTC_1638 st008370 60.6 µM -2.42834911515716 0.00520729322080388 no 3322 0.00758386745254075 1062 24207134 SGTC_312 4092-0653 6.84 µM -2.43181081264994 0.0051532326883387 no 3323 0.00751177611059261 1060 1148278 SGTC_2280 7785178 200 µM -2.45745725447009 0.00476803546986618 no 3324 0.00699622307628892 1075 2954328 SGTC_3300 9124615 50.48 µM -2.47594318165874 0.00450652772343782 no 3325 0.00664423619390058 1081 24824903 SGTC_1448 4255-0083 152 µM -2.49922660205524 0.00419541787691994 no 3326 0.00622323479001826 1085 5399660 SGTC_2287 7945887 168.79 µM -2.53340786139037 0.00377345607921089 no 3327 0.0056479716363049 1084 1245853 SGTC_430 0958-0115 16.4 µM -2.55223541780516 0.00355765787420665 no 3328 0.00535170848260063 1081 6833180 SGTC_86 0417-1630 471.922 µM -2.5597486090347 0.00347468246840195 no 3329 0.0052373952334758 1075 3634867 SGTC_1856 st057054 55.7 µM -2.60154991720941 0.00304397753994785 no 3330 0.00464017791590713 1077 1266018 SGTC_2676 harmalol 100 µM -2.60669847346944 0.00299439896965895 no 3331 0.00457099125680908 1087 5459187 A monoamine oxidase inhibitor SGTC_1841 st054148 70 µM -2.61038385850076 0.00295935823583173 no 3332 0.00452203380797907 1089 675442 SGTC_1146 3579-1023 7 µM -2.64067494663725 0.00268506142585518 no 3333 0.00413705308489879 1092 X1146 SGTC_853 0419-0306 21 µM -2.64876308812263 0.0026158125445588 no 3334 0.00403934710932486 1092 762713 SGTC_2604 4'-hydroxychalcone 11.32 µM -2.65771693119968 0.00254103684378426 no 3335 0.00393359703922941 1083 5282362 SGTC_354 2783-3500 4.88 µM -2.66251136141555 0.00250179672649198 no 3336 0.00387799756181624 1084 6740761 SGTC_3192 9110362 49.47 µM -2.67718902112012 0.00238504987348082 no 3337 0.00371213685496734 1088 16649480 SGTC_1962 st076595 64.5 µM -2.76894155477501 0.00176039597093131 no 3338 0.00281193612968171 1076 279619 SGTC_2386 9075165 157.42 µM -2.77342705419099 0.00173407458267358 no 3339 0.00277346373501723 1091 16452277 SGTC_1520 flindersine 88 µM -2.96219956756773 0.000902947272458231 yes 3340 0.00152724867498594 1081 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1692 fluoroquinolonic acid 71 µM -3.01242486494355 0.000754395961905824 yes 3341 0.00129584792312723 1090 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2378 9074213 121.43 µM -3.01359493628706 0.000751220453772408 yes 3342 0.00129086125687733 1091 657714 SGTC_174 3553-0389 74.3 µM -3.08755678036347 0.000573761167871296 yes 3343 0.00100904607052292 1090 738071 SGTC_1821 st053465 65.6 µM -3.11186750491659 0.000524481543183114 yes 3344 0.000929539583147733 1095 675086 SGTC_3035 9091303 49.47 µM -3.18436737376947 0.000399811599105386 yes 3345 0.00072535385589669 1094 25237002 SGTC_1672 st016598 6.51 µM -3.34711449558703 0.000213152402783577 yes 3346 0.000408287379728677 1092 4665860 YNL267W PIK1 SGTC_1682 st012968 530 nM -3.40387342749906 0.000170070594486891 yes 3347 0.000332187657162898 1087 24207270 SGTC_428 3448-4153 16.5 µM -3.41262059739243 0.000164205707057984 yes 3348 0.000321707256089773 1093 3834874 SGTC_220 paclitaxel 373.376 µM -3.4731672769517 0.000128513536474187 yes 3349 0.000257177335068308 1089 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_351 caspofungin 25 nM -3.67217017901276 5.59072511979574e-05 yes 3350 0.000120249718198239 1091 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3031 9088762 49.47 µM -3.68776529459999 5.22858928237127e-05 yes 3351 0.000113116087431812 1094 205253 SGTC_521 r062-0005 13.8 µM -4.76806654793833 2.71771488432746e-07 yes 3352 9.30011742799285e-07 1094 2832033 SGTC_553 k007-0256 45.7 µM -5.04922110686175 5.64922063171156e-08 yes 3353 2.21807527253031e-07 1095 6287000 SGTC_2316 5844804 197.44 µM -5.19570895131051 2.41040296724469e-08 yes 3354 1.01970559775223e-07 1093 776813 SGTC_514 4466-0038 2.65 nM -5.21227275276891 2.18595009482757e-08 yes 3355 9.32705039462178e-08 1093 5722064 SGTC_3197 9113331 49.47 µM -5.32687668786259 1.10270617128221e-08 yes 3356 4.99579730553453e-08 1093 16610459 YLR208W | YDL195W SEC13 | SEC31