SGTCid condition conc unit RNP1|YLL046C.score RNP1|YLL046C.strain.pval RNP1|YLL046C.strain.significant RNP1|YLL046C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_746 1095-0025 46.6 µM 6.8914767402756 1.02779833619455e-13 yes 1 2.7608075609622e-12 4 6749286 SGTC_735 3076-0345 636 µM 5.07708887160287 2.96668153948633e-08 yes 2 1.91630816599224e-07 10 2888990 SGTC_361 000s-0510 1.45 µM 4.85579533522836 1.0737472136195e-07 yes 3 5.99522485591972e-07 18 660 SGTC_2876 9059903 25.97 µM 4.24406039021546 2.84906662545785e-06 yes 4 1.09755618106704e-05 5 6916095 SGTC_644 1498-1197 63.3 µM 3.9382594274759 1.26022697157799e-05 yes 5 4.10374140714566e-05 20 6741615 SGTC_2871 9038510 12.99 µM 3.87831634725309 1.66684919132179e-05 yes 6 5.25909430134674e-05 18 4945164 SGTC_2861 9024595 19.48 µM 3.73504274116957 3.20170195822594e-05 yes 7 9.38416543185571e-05 3 16482810 SGTC_654 1124-0271 80.9 µM 3.56333602729185 6.8003790508364e-05 yes 8 0.00018308572936819 39 5403748 SGTC_1263 0774-1208 64.8 µM 3.55218963146415 7.13340509239786e-05 yes 9 0.000191019711897203 63 906585 SGTC_2851 9015922 71.43 µM 3.48796470061635 9.37160979500231e-05 yes 10 0.000243356165659628 61 2996893 SGTC_2572 astragaloside iv 100 µM 3.31513709053023 0.0001910997199083 yes 11 0.000457990956318892 53 45006101 An anti-inflammatory agent. SGTC_676 falcarinol 140 µM 3.2787927839729 0.000221094878370927 yes 12 0.000521260782513208 84 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2054 5233173 129 µM 3.27703916717286 0.000222647802831913 yes 13 0.000524509082637949 89 6889 SGTC_73 0327-0325 16.231 µM 3.26122623616326 0.00023711807390369 yes 14 0.000554657468469652 84 53298 SGTC_2208 7283366 200 µM 3.22112327432085 0.000277843815921271 yes 15 0.000638446059593716 24 898663 SGTC_2371 9071574 200 µM 3.20738588675348 0.000293231433862122 yes 16 0.000669735948261389 32 45596039 SGTC_1435 4092-0789 56.7 µM 3.1559591112224 0.000358159165692273 yes 17 0.000799856422438604 39 2248285 SGTC_749 1000-0129 128 µM 3.14982085868988 0.000366744049600764 yes 18 0.000816853021199502 52 708470 SGTC_2241 6772625 37.8075 µM 3.14135074522829 0.000378904359702855 yes 19 0.000840852502553974 56 2285411 SGTC_2340 7987427 183.45 µM 3.13351361179214 0.000390488376255363 yes 20 0.000863634535002189 71 2239331 SGTC_2087 5276107 200 µM 3.124226359665 0.000404641160445168 yes 21 0.000891366268247604 59 144405 SGTC_381 3461-2219 42.7 µM 3.10869012520196 0.000429385307687482 yes 22 0.000939593478018765 52 2883159 SGTC_656 4090-1979 187 µM 3.08681155254383 0.000466615903349212 yes 23 0.00101157905589283 56 22330961 SGTC_1946 st076057 65.1 µM 3.00519334543257 0.000633493316889851 yes 24 0.00132706038264071 25 953009 SGTC_686 1319-0111 510 µM 2.99149490888211 0.000666390702000599 yes 25 0.00138807583620804 66 4562600 SGTC_2528 xanthyletin 44.79 µM 2.95256762310988 0.000768673191036795 yes 26 0.00157571518023651 61 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2441 5730946 39.09 µM 2.94796691056784 0.000781673046381829 yes 27 0.00159935650569297 63 1774275 SGTC_1370 2001-0092 44.6 µM 2.8245178330889 0.00121577974629705 no 28 0.00236759065882151 104 790957 SGTC_683 panaxydol 45 µM 2.76985050422285 0.00147091908468873 no 29 0.00280410134031363 92 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2593 nobiletin 86.24 µM 2.76259336503292 0.00150823769799887 no 30 0.0028672079268956 88 72344 An anti-infammatory. SGTC_2606 farnesol 9.78 µM 2.6745378653628 0.00203514215164357 no 31 0.00374161625295831 97 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2218 6965428 192.983 µM 2.66781527853583 0.00208154101117636 no 32 0.00381731103164134 53 675684 SGTC_2347 9049783 174.81 µM 2.65611335922798 0.00216460158777408 no 33 0.0039523518815059 119 6467988 YPL169C MEX67 SGTC_473 2-arachidonoylglycerol 10 µM 2.63024833557895 0.00235894921055747 no 34 0.00426612580157475 85 5282280 An endocannabinoid. SGTC_3336 9143619 71.43 µM 2.61495929358388 0.00248112691291949 no 35 0.00446190450819792 94 45595730 SGTC_1235 benzylparaben 21.5 µM 2.61470543460403 0.00248320298442963 no 36 0.00446522185813254 72 7180 SGTC_1711 st032263 62.8 µM 2.59139591326142 0.00268065897594167 no 37 0.00477937262214144 86 3958979 SGTC_873 0591-4978 488 µM 2.58983673217833 0.00269435956602609 no 38 0.00480107304170777 90 3305145 SGTC_809 3998-0021 90 µM 2.5850010161214 0.00273725426170168 no 39 0.00486893552111603 66 715485 SGTC_1010 4112-3296 15.2 µM 2.54643208219982 0.00310205398391506 no 40 0.00544151935439121 112 704384 SGTC_3211 9128781 49.47 µM 2.50470372746621 0.00354552957736158 no 41 0.00612770015226117 181 17194361 SGTC_1381 2324-0066 62.1 µM 2.48210479600012 0.00380875621303639 no 42 0.00653044288436843 150 10885928 SGTC_3342 9147791 14.508 µM 2.47457030934614 0.0039003330506498 no 43 0.00666982805292241 97 1838168 SGTC_544 k015-0020 52.4 µM 2.47396608553405 0.00390776175731745 no 44 0.00668111903846099 116 3008304 SGTC_1524 corynanthine 62.1 µM 2.47250413222499 0.00392578839469713 no 45 0.00670850812613599 116 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2847 9005661 71.43 µM 2.46083985681988 0.0040723039270826 no 46 0.0069306110713065 52 2991449 SGTC_1295 1013-0063 9.78 µM 2.44868930197941 0.00423011413306776 no 47 0.00716885330065217 112 6826038 SGTC_1196 1588-0294 184 µM 2.44848727844154 0.00423278359008325 no 48 0.00717287479427867 99 6144269 SGTC_2379 9035213 200 µM 2.43336106740215 0.00443698522824662 no 49 0.00747968755849405 120 646551 SGTC_1186 1319-0216 26 µM 2.42516803913857 0.00455122516478963 no 50 0.00765065119813605 127 4565136 SGTC_650 1328-0195 38 µM 2.41569868448028 0.00468652725420419 no 51 0.00785252582132273 141 2780821 SGTC_1428 4049-0204 61.7 µM 2.40498108306924 0.00484398433444393 no 52 0.00808665147892117 112 X1428 SGTC_2166 5933061 31.504 µM 2.39428117475965 0.0050058683320861 no 53 0.00832648855392984 152 2877375 SGTC_1735 st034310 56.75 µM 2.38629541208242 0.00512981091915705 no 54 0.00850953693554216 137 871153 SGTC_1560 lithocholic acid 53.1 µM 2.38528389908184 0.00514570338662608 no 55 0.00853297281213081 55 9903 A bile acid which acts as a detergent. SGTC_6 0844-0013 19.835 µM 2.38258907384706 0.00518825744692217 no 56 0.00859568619899131 337 1584900 SGTC_3125 9127534 49.47 µM 2.33690532075894 0.00595886354647085 no 57 0.00972205381511455 90 1639235 SGTC_2336 9001819 198.65 µM 2.32819709673387 0.0061167698339242 no 58 0.00995082014200828 199 2989602 SGTC_432 NS 1619 61.3 µM 2.31827967681486 0.00630110845733884 no 59 0.0102170630991613 161 4552 A K+/calcium channel activator. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 2.31462917830974 0.00637018993595941 no 60 0.0103166173119095 126 803109 SGTC_1811 st050069 61.5 µM 2.30353078668598 0.00658434850924801 no 61 0.0106244985118204 76 3877702 SGTC_2295 7971645 200 µM 2.28656619490207 0.00692401189549402 no 62 0.0111105781443998 155 2978226 YKL099C UTP11 SGTC_2327 6189656 200 µM 2.27471361162144 0.00717041494074538 no 63 0.0114615577071006 138 5349088 SGTC_2820 7989630 71.43 µM 2.27275284995768 0.00721191435436901 no 64 0.011520538922672 120 2984098 SGTC_2898 9056270 58.44 µM 2.2636026943045 0.00740839024328189 no 65 0.0117992809976698 86 19154699 SGTC_1115 galangin 695.678 nM 2.26273764060571 0.0074272068459113 no 66 0.0118259335142363 160 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3157 9099274 49.47 µM 2.24774285187947 0.00776013042918365 no 67 0.0122962959154551 122 17217662 SGTC_500 h-89 112 µM 2.2238433970607 0.00831793457152071 no 68 0.0130794912302079 176 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1955 wogonin 32.4 µM 2.21261662629355 0.00859190539368742 no 69 0.0134620438897971 140 5281703 A flavanone. SGTC_70 0141-0289 43.283 µM 2.21071291828757 0.00863913899167364 no 70 0.0135278616930123 438 352408 SGTC_462 ag-879 158 µM 2.20583230521377 0.00876127551780271 no 71 0.0136978717291094 198 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_430 0958-0115 16.4 µM 2.19562938296016 0.00902150148955897 no 72 0.0140592406818494 181 6833180 SGTC_3066 9117245 49.47 µM 2.18284140164414 0.0093572011655985 no 73 0.0145237457909542 159 17176980 SGTC_1510 1123-0200 71.5 µM 2.1792172961433 0.00945430400187464 no 74 0.0146577648190859 232 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_522 1273-0010 11.6 µM 2.17278371904923 0.00962885472493693 no 75 0.0148982996195238 178 5705015 SGTC_418 lividomycin a 100 µM 2.17259711323177 0.00963395932294565 no 76 0.0149053266774394 152 72394 An antibiotic. SGTC_1375 2910-0797 186 µM 2.16817129814277 0.00975572257631928 no 77 0.0150728278642104 180 742508 SGTC_2 0422-0095 29 µM 2.16637766004111 0.00980545078094092 no 78 0.0151411698240277 95 6790840 SGTC_2401 5128683 200 µM 2.15727578051818 0.0100612253247156 no 79 0.0154920914725378 190 708373 SGTC_2886 9058944 51.95 µM 2.14266365752858 0.0104840261616024 no 80 0.0160700577947326 66 4949929 SGTC_135 0933-0004 26.348 µM 2.13976584064458 0.0105696899595327 no 81 0.0161868475499167 199 21230617 YGL099W LSG1 SGTC_12 0849-0099 9.267 µM 2.13619246437627 0.0106761633862888 no 82 0.0163318647127348 156 6071388 SGTC_1855 st056195 39.6 µM 2.13429761189841 0.0107330010622566 no 83 0.0164092133206176 183 4028379 SGTC_1558 st069300 45.6 µM 2.10016337938115 0.0118029464941955 no 84 0.017857235782764 124 24208000 SGTC_2442 5158906 48.48 µM 2.10009958460761 0.0118050298103503 no 85 0.0178600409316437 195 1893835 SGTC_822 1487-0950 154 µM 2.09160150207108 0.0120854154432502 no 86 0.0182370890289294 189 1958375 SGTC_1189 1431-2119 7.28 µM 2.07435559221856 0.0126722178912584 no 87 0.0190231491759502 254 3107275 SGTC_3330 9141424 71.43 µM 2.06402176522813 0.0130355184475251 no 88 0.0195078263945562 211 27261020 SGTC_2275 7947463 200 µM 2.06095365194749 0.0131451012357885 no 89 0.0196537310048577 184 1225414 SGTC_916 4466-0038 42 nM 2.05253298720814 0.0134499591380718 no 90 0.0200589463007926 309 5722064 YGL116W CDC20 SGTC_2804 7954240 19.48 µM 2.04802407373219 0.0136156931685075 no 91 0.0202788202982352 227 828705 SGTC_485 niflumic acid 177 µM 2.04396256164711 0.0137664878463649 no 92 0.0204786229117283 175 4488 A COX2 inhibitor. SGTC_1561 5-methoxyflavone 52.9 µM 2.02823666879263 0.0143640193484912 no 93 0.0212680495583105 125 94525 SGTC_2074 5212007 75.395 µM 2.02306984424746 0.0145651552768154 no 94 0.0215329735422419 172 758611 SGTC_303 1348-1668 34.2 µM 2.00569812891682 0.0152592798132142 no 95 0.022444232485992 169 5380509 SGTC_713 1488-1073 324 µM 2.0000672461914 0.0154902880692419 no 96 0.0227465015054531 175 3312542 SGTC_1187 1391-0724 117 µM 1.99166999167155 0.0158403610544514 no 97 0.0232036391554287 224 6997986 SGTC_3147 9097027 49.47 µM 1.988283198224 0.015983461133505 no 98 0.0233901889734781 230 25236841 SGTC_705 1124-0212 310 µM 1.98534384102097 0.0161085528022726 no 99 0.0235531147510807 229 9554485 SGTC_2326 6164455 177.58 µM 1.98237702618567 0.0162356627852479 no 100 0.0237185294493684 213 2888790 SGTC_1419 3993-2473 62.6 µM 1.96210263419431 0.0171275052983863 no 101 0.0248752681672147 223 704026 SGTC_2300 7976697 71.57 µM 1.95914754530775 0.0172609288641007 no 102 0.0250477550410356 218 2236109 SGTC_2271 7849410 118.62 µM 1.95676935977786 0.0173689488680442 no 103 0.0251872954985326 217 972430 SGTC_1908 st060353 56.5 µM 1.95574221123552 0.0174157813925059 no 104 0.0252477647550115 288 4227716 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.95463775972327 0.0174662587907519 no 105 0.0253129205854643 246 94937 An inhibitor of serotonin biosynthesis. SGTC_3205 9113483 49.47 µM 1.95045453378626 0.0176585813565998 no 106 0.0255609837161498 275 17018033 SGTC_2052 5265182 7.135 µM 1.94938144024355 0.0177082067799786 no 107 0.0256249446469499 250 1239884 SGTC_646 4092-0839 27.3 µM 1.94841629957924 0.0177529414979232 no 108 0.0256825855264584 227 877796 SGTC_1346 1488-2224 62.4 µM 1.94374140959555 0.0179709918096331 no 109 0.0259633211708568 213 3722427 SGTC_1032 k061-1018 98.7 µM 1.9431261040646 0.0179998607982559 no 110 0.0260004618584664 286 4005393 SGTC_595 3909-8003 73.7 µM 1.93954597140817 0.0181686194665626 no 111 0.0262174462176289 236 699517 SGTC_1368 1852-0141 284 µM 1.93790311568145 0.0182465098980116 no 112 0.0263175218928946 243 2838987 SGTC_390 dec-rvkr-cmk 16.7 µM 1.93557451648552 0.0183573998849796 no 113 0.0264599169988026 265 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_808 0711-0032 135 µM 1.92042819244977 0.0190927824731499 no 114 0.0274019176553476 214 4252555 SGTC_2115 tiliquinol 12.7705 µM 1.91735407783647 0.0192450554819013 no 115 0.0275964820403928 196 71208 A bioactive hydroxyquinoline. SGTC_1654 st012436 41.8 µM 1.90376723228996 0.0199304863803337 no 116 0.0284702529355548 209 4323132 SGTC_377 3970-0964 33.1 µM 1.90271793229962 0.0199842726408404 no 117 0.0285386803793014 354 16481235 SGTC_1818 st052136 56.3 µM 1.90249634639952 0.0199956466876215 no 118 0.0285531480251266 281 674169 SGTC_2378 9074213 121.43 µM 1.88954548784726 0.0206700237614241 no 119 0.0294093868209927 274 657714 SGTC_1309 pyrazolanthrone 13.4 µM 1.87965326803202 0.0211980194481772 no 120 0.0300776742160613 270 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2918 7977171 22.06 µM 1.86681843011861 0.0219000408515393 no 121 0.0309634739399069 250 2236483 SGTC_1061 3448-9325 110 µM 1.86207894546719 0.0221641907705269 no 122 0.0312959816390336 204 723482 SGTC_3230 9131665 49.47 µM 1.86015651780383 0.0222720990404731 no 123 0.0314316924612924 104 15943720 SGTC_2823 7987624 58.44 µM 1.85864181375448 0.0223574331692923 no 124 0.0315389630409969 308 2239440 SGTC_3041 9091929 49.47 µM 1.85556693936986 0.0225315112574196 no 125 0.0317576548398981 283 25236887 SGTC_2092 5303694 80.6725 µM 1.85265898970732 0.0226971893046634 no 126 0.0319656257909582 297 1963699 SGTC_1438 4092-1045 4 µM 1.84810329445277 0.0229588101028831 no 127 0.032293700649936 243 1351342 SGTC_1395 3486-0190 4.35 µM 1.83913729100977 0.0234811253453435 no 128 0.0329474976585769 272 6748079 SGTC_3226 9131256 49.47 µM 1.83899161538621 0.0234896935463057 no 129 0.0329582096609603 120 17178073 SGTC_41 0478-0632 82.643 µM 1.83606067277229 0.0236626423695255 no 130 0.0331743419163653 314 3750424 SGTC_3110 9122132 49.47 µM 1.83109600769521 0.0239580398588473 no 131 0.0335431071598633 246 918317 SGTC_1365 1672-3266 55.4 µM 1.8255608466939 0.0242910293159542 no 132 0.0339582189971178 287 6415873 SGTC_1255 0566-0045 221 µM 1.82162019629625 0.0245304558286354 no 133 0.0342563171608084 302 2788469 SGTC_549 1661-1316 519 µM 1.80916626906193 0.0253001906638226 no 134 0.0352125881174346 287 2857282 SGTC_1911 st060208 74.3 µM 1.80308140340258 0.0256835734078924 no 135 0.0356877156361714 304 688783 SGTC_2013 4024628 200 µM 1.79953008167099 0.0259095667754385 no 136 0.0359674349330748 295 5230760 SGTC_2420 aureobasidin a 50 nM 1.79912162234828 0.0259356660218004 no 137 0.0359997220099561 351 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_774 k060-0086 136 µM 1.79295572557957 0.0263323265230635 no 138 0.0364900018840618 316 5911235 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.79144317246362 0.0264304019137848 no 139 0.0366111030831797 288 6708760 SGTC_2164 5685496 200 µM 1.78773158378667 0.0266723591165112 no 140 0.036909661769582 275 759046 SGTC_2225 6654152 15.4 µM 1.78747190435755 0.0266893565542687 no 141 0.0369306245683729 205 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3007 9078383 71.4286 µM 1.78681708094416 0.0267322584995335 no 142 0.0369835288560769 284 6496995 SGTC_2432 5630864 12.22 µM 1.78203901904883 0.0270470483545146 no 143 0.0373714344881415 299 5714970 SGTC_917 harmaline 728.087 nM 1.77923149998329 0.027233452952074 no 144 0.0376009080200554 314 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2155 5570423 76 µM 1.7673061049404 0.0280372215085066 no 145 0.0385884889952942 289 797402 SGTC_2899 9053889 58.44 µM 1.75921003883146 0.0285940762877908 no 146 0.0392709198908152 240 6470052 SGTC_2285 7945142 200 µM 1.75508139605713 0.0288815711733869 no 147 0.0396226930097006 303 2970608 SGTC_2106 5357045 167.29 µM 1.74783794895714 0.0293917676245363 no 148 0.0402460460184517 315 668842 SGTC_358 0075-0058 9.45 µM 1.74456258934518 0.0296249145063029 no 149 0.0405305188176975 419 1069125 SGTC_2479 5617353 43.85 µM 1.7375666077718 0.0301280455690771 no 150 0.041143603973855 328 2731746 SGTC_1332 1480-0653 17.5 µM 1.73750237948348 0.0301326972980251 no 151 0.0411492671911113 306 5749438 SGTC_1975 st070967 30.8 µM 1.73500588605261 0.0303139675199298 no 152 0.0413698813265006 350 261391 SGTC_1590 st077108 57.8 µM 1.72040263408771 0.0313924975665425 no 153 0.0426796392648127 264 5489485 SGTC_3084 9116877 49.47 µM 1.72008025650439 0.0314166602865064 no 154 0.042708927023538 239 27241325 SGTC_1445 4239-0156 97.7 µM 1.71563796227755 0.0317511860145886 no 155 0.043114162917148 361 4008346 SGTC_2387 9077560 195.08 µM 1.71419428143304 0.0318605335685551 no 156 0.0432465254019678 325 5303272 SGTC_1938 st074717 56.4 µM 1.70832298690751 0.0323084479154549 no 157 0.0437882141663712 263 17250979 SGTC_1251 0490-5699 265 µM 1.70428646100924 0.0326193943907517 no 158 0.0441637915508576 379 3883818 SGTC_987 1497-1013 404 µM 1.70391455520848 0.0326481672381014 no 159 0.0441985256818409 274 1676435 SGTC_716 1683-5115 658 µM 1.6993774912416 0.0330008696395256 no 160 0.0446240401188622 374 723597 SGTC_2848 9016370 25.97 µM 1.69601025890333 0.0332646566211992 no 161 0.0449419686238965 364 7894410 SGTC_599 1935-0052 86.5 µM 1.69529460682806 0.0333209435648906 no 162 0.0450097736986314 343 9557311 SGTC_1188 1403-0014 4.57 µM 1.69297243284469 0.0335041259032272 no 163 0.0452303573034396 402 9614867 SGTC_2158 5657123 3.6195 µM 1.69278470306589 0.0335189709249929 no 164 0.0452482277108713 278 2858827 SGTC_2742 clothiapine 36.27 µM 1.68943175174047 0.0337850239366898 no 165 0.0455683602354081 253 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_919 tnp00227 403.569 nM 1.68314271788465 0.0342887372487433 no 166 0.0461737333121194 375 1269246 A methoxyflavone. YNL221C POP1 SGTC_2744 captopril 92.04 µM 1.68262156922622 0.0343307535729938 no 167 0.0462241867388059 235 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2752 diclazuril 33.15 µM 1.6808563739176 0.0344733825700386 no 168 0.0463954077764498 499 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_937 3122-0005 46.7 µM 1.67966174960654 0.0345701849917129 no 169 0.0465115729802681 349 759535 SGTC_353 1988-1175 58.3 µM 1.67370679620356 0.0350560609646449 no 170 0.047094118731037 309 2788357 SGTC_821 1114-0266 29.2 µM 1.67263194212685 0.0351443545946888 no 171 0.0471998873505235 324 3123235 SGTC_2641 levomentholum 100 µM 1.66166024128814 0.036056100414215 no 172 0.0482904586129305 251 16666 SGTC_152 4469-0003 551.229 µM 1.66149934396824 0.0360696137134831 no 173 0.048306600283493 320 697280 SGTC_1048 3161-0300 24.5 µM 1.66136735073478 0.0360807025390489 no 174 0.0483198454374154 358 2165101 SGTC_609 0986-0026 86.3 µM 1.66014272191786 0.036183717458791 no 175 0.0484428720878106 378 2848610 SGTC_1433 4060-0023 7.6 µM 1.65892400399592 0.036286474109331 no 176 0.0485655534920412 344 3840627 SGTC_2221 6807166 181.081 µM 1.65869120654198 0.0363061296599299 no 177 0.0485890161213737 234 674925 SGTC_2237 6667747 47.222 µM 1.65531052262198 0.0365925510166335 no 178 0.0489307627726089 306 729940 YDL015C TSC13 SGTC_186 3455-3465 67.277 µM 1.65119054625857 0.0369441037475708 no 179 0.0493498364448132 210 755278 SGTC_421 streptovitacin 30 mM 1.65115467538542 0.0369471766490055 no 180 0.0493534976837773 384 91467 include heat shock SGTC_1143 3454-2408 5.08 µM 1.64221181610793 0.037719817275219 no 181 0.0502730573768505 265 X1143 SGTC_634 1611-4317 11.2 µM 1.63803859507999 0.0380848600217688 no 182 0.0507068214575913 380 2843522 SGTC_3 0833-0587 95.581 µM 1.63673108831572 0.03819982219221 no 183 0.0508433350784271 316 5382644 SGTC_110 0850-0284 111.64 µM 1.63603917881429 0.0382607725523589 no 184 0.050915693982604 220 3906265 SGTC_564 3555-0129 330 µM 1.63588873047358 0.038274036048364 no 185 0.0509314385001458 257 563260 SGTC_940 3232-1287 54.8 µM 1.6316771333666 0.0386468535921299 no 186 0.051373759817905 347 1585493 YIL048W NEO1 SGTC_610 4215-0184 155 µM 1.62965499834504 0.0388269048534928 no 187 0.0515872167339426 376 5605015 SGTC_1927 st060202 13.8 µM 1.62908640665378 0.0388776552426367 no 188 0.0516473642191278 334 688887 SGTC_1750 st081859 2.357 µM 1.62427302847139 0.0393094473858514 no 189 0.0521587754611749 588 5291695 SGTC_598 3937-0236 20.2 µM 1.60906726955248 0.0406992004737107 no 190 0.0538008165905821 414 1379313 SGTC_39 0986-0283 58.349 µM 1.60081681352356 0.04146979228945 no 191 0.0547087492497441 431 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2591 skatole 100 µM 1.59973282944732 0.0415719093057473 no 192 0.0548289328148452 359 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2536 dehydroabietamide 32.04 µM 1.59130769775214 0.0423725638095883 no 193 0.0557701726399848 405 3983547 SGTC_2375 9072683 200 µM 1.59084100165167 0.0424172768426519 no 194 0.05582268145103 403 16798029 SGTC_2179 6298986 200 µM 1.59082327150395 0.0424189762777316 no 195 0.0558246770704234 322 738374 SGTC_2187 6125751 200 µM 1.58916610142069 0.0425780593563266 no 196 0.0560114487204109 370 874498 SGTC_2919 7978188 46.38 µM 1.58433568850758 0.0430445177266907 no 197 0.056558674224349 389 2980291 SGTC_1569 carminic acid 40.6 µM 1.57908836496485 0.0435559051772102 no 198 0.0571578950253494 371 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2863 9028737 58.44 µM 1.57208381320442 0.0442461759699573 no 199 0.0579655574690869 312 6460917 SGTC_1628 st004252 77.7 µM 1.56795519762975 0.044657147629986 no 200 0.0584457942622588 396 692968 SGTC_2929 9013348 24.6 µM 1.56175367192752 0.0452802330813115 no 201 0.0591730147450479 393 2995952 SGTC_1330 1469-0054 61.8 µM 1.55999392343375 0.0454583083546737 no 202 0.059380658588827 385 7102664 SGTC_507 nimesulide 162 µM 1.5504504882088 0.0464338741572445 no 203 0.0605167142345309 392 4495 A COX2 inhibitor. SGTC_3012 9080433 71.4286 µM 1.53986653236861 0.0475353854841489 no 204 0.0617964450897961 405 17688859 SGTC_287 k060-0039 29.6 µM 1.53732038716413 0.0478034716081482 no 205 0.0621074357029037 372 5861974 SGTC_689 0833-0039 98 µM 1.53660845990802 0.047878647298301 no 206 0.0621946098155711 400 5374726 SGTC_1680 diphenhydramine 100 µM 1.53391966299053 0.048163423887549 no 207 0.0625247089895025 408 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1694 st024011 44.9 µM 1.53391319399451 0.0481641106642991 no 208 0.0625255048213075 434 2787533 SGTC_725 1497-0963 19 µM 1.53343060234308 0.0482153667927305 no 209 0.0625848967055539 383 3549977 SGTC_649 1123-0311 367 µM 1.52868870004284 0.0487213292487284 no 210 0.063170817467382 468 693629 YIL048W NEO1 SGTC_2959 9079155 11 µM 1.52197409202788 0.0494450295526754 no 211 0.0640077862372663 358 16189457 SGTC_1333 1482-0047 286 µM 1.52063999215154 0.0495898355566168 no 212 0.0641751025484085 442 3811116 SGTC_1149 3909-7961 23.3 µM 1.51801645944575 0.0498755863440346 no 213 0.0645051246948653 397 735261 SGTC_2430 5571206 200 µM 1.51744907514777 0.0499375572869382 no 214 0.0645766707919325 465 1731771 SGTC_3152 9099253 49.47 µM 1.51650303418939 0.0500410224723836 no 215 0.0646961018404035 538 25236131 SGTC_2917 7979103 53.79 µM 1.5136050364492 0.0503590304292083 no 216 0.0650630214946114 472 2980565 SGTC_1556 plumbagin 1.48 µM 1.50932914030177 0.0508311790183547 no 217 0.0656073457082406 343 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2753 fluvastatin 17.09 µM 1.50865749376508 0.0509056621456737 no 218 0.065693166670364 450 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2278 7948257 134.34 µM 1.50848216773313 0.0509251194506824 no 219 0.0657155836184025 401 1247028 SGTC_1390 3413-2614 145 µM 1.5032255007619 0.0515112476264598 no 220 0.0663904518709523 434 3421432 SGTC_190 3970-0790 3.722 µM 1.50108463143851 0.0517514905335683 no 221 0.0666668366541589 378 2832352 SGTC_941 3237-0776 460 µM 1.50037696775539 0.0518310983156397 no 222 0.0667583911138846 390 760008 SGTC_2048 5246248 200 µM 1.50003274162789 0.0518698567917556 no 223 0.0668029607560681 364 677046 SGTC_2522 biochanin a 4.94 µM 1.49543305851288 0.0523899757635871 no 224 0.0674007291242998 376 5280373 A possible chelator. SGTC_1679 SEC14.276 6.7 µM 1.48244976065272 0.0538804493222227 no 225 0.0691103309703849 507 1005053 YMR079W SEC14 SGTC_851 0394-0702 453 µM 1.48206253646079 0.0539254127146825 no 226 0.0691618279759658 457 762646 SGTC_2829 7992743 58.44 µM 1.48078988198036 0.0540733990905877 no 227 0.0693312867846972 448 16462845 SGTC_151 3013-0144 2.285 µM 1.48077627656901 0.0540749828852267 no 228 0.0693331001235389 446 906558 YHR107C CDC12 SGTC_2661 dactinomycin 12.96 µM 1.47808240222481 0.0543892985923923 no 229 0.0696928618545922 462 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2544 sphondin 68.51 µM 1.47404024628662 0.0548636382644194 no 230 0.0702353776654803 396 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2046 4110841 106 µM 1.47303511229098 0.0549820950626456 no 231 0.0703707841174556 420 44119630 YMR134W ERG29 SGTC_2186 6124449 200 µM 1.4730324183888 0.0549824128150685 no 232 0.0703711472955297 408 3834182 YLR033W RSC58 SGTC_1813 st051246 8.6015 µM 1.46232737804364 0.0562566009492881 no 233 0.071825759772693 385 5291959 SGTC_2428 5615643 7.78 µM 1.46069474418501 0.0564529581027249 no 234 0.0720496160341528 442 2253075 SGTC_2258 7960471 200 µM 1.46046324023294 0.0564808447950385 no 235 0.0720814016201987 340 2974708 SGTC_935 2996-0153 430 µM 1.45961793656108 0.0565827612731653 no 236 0.0721975534459953 424 23738523 SGTC_111 0083-0039 52.457 µM 1.45878222987041 0.0566836630510577 no 237 0.0723125275316997 272 759313 SGTC_1650 st011916 45.8 µM 1.45778256570834 0.0568045469004586 no 238 0.072450242640527 394 242528 SGTC_687 k029-0044 34.9 µM 1.4567083772488 0.0569346687759829 no 239 0.0725984481773802 460 5829338 SGTC_603 3794-0023 45.9 µM 1.45186694241937 0.0575240512863429 no 240 0.0732693029404569 409 3802260 SGTC_848 0368-0089 85.6 µM 1.4517455277227 0.0575388934202109 no 241 0.0732861875533335 458 762535 SGTC_475 α-linolenic acid 10 µM 1.45124499335501 0.0576001122031635 no 242 0.0733558261174337 468 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1678 st019265 80.2 µM 1.44436441097163 0.058446856530272 no 243 0.0743182480725866 484 5367020 SGTC_1382 3002-2117 298 µM 1.44248322845976 0.0586800537254628 no 244 0.074583049792361 462 1497314 SGTC_440 fluspirilene 35.1 µM 1.44010003973855 0.0589765291428711 no 245 0.0749195489356865 471 3396 An atypical antipsychotic. SGTC_2913 7966556 36.57 µM 1.43216438814961 0.0599722244644953 no 246 0.0760483903990199 419 2976516 SGTC_1689 st020265 53.493 µM 1.4284837660103 0.060438482980522 no 247 0.0765763319881044 444 5758320 YPR016C TIF6 SGTC_2415 st077333 57.7 µM 1.4243543250391 0.0609649687737864 no 248 0.0771719644927551 543 2766255 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.41885695353145 0.0616714153003997 no 249 0.077970362161324 741 16725076 SGTC_2839 9003951 25.97 µM 1.41869304391125 0.0616925764227084 no 250 0.0779942630442075 429 2990634 SGTC_2765 myclobutanil 7.74 µM 1.41367247669136 0.0623434937623575 no 251 0.0787290450878138 486 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2079 5212404 121 µM 1.41185946322654 0.0625798631513553 no 252 0.0789956728130049 445 758462 SGTC_1808 st050063 61.5 µM 1.40625874951432 0.0633144631289382 no 253 0.0798236522250223 457 4011993 SGTC_784 4579-0127 173 µM 1.39969120513826 0.0641844063671005 no 254 0.0808029043005323 509 1948547 SGTC_938 3126-1755 342 µM 1.39901733401955 0.0642741910195004 no 255 0.0809038925505013 499 1777771 SGTC_189 3970-0742 2.116 µM 1.39677275196435 0.0645739568564992 no 256 0.0812409593090686 447 2891807 SGTC_1177 0983-0204 23.6 µM 1.39455887217661 0.0648706850688994 no 257 0.0815744523326221 513 766818 SGTC_2763 lisinopril 49.32 µM 1.39455649086978 0.0648710048064743 no 258 0.0815748116013334 431 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2342 7990637 118.86 µM 1.39381423053368 0.0649707275892873 no 259 0.0816868548692504 508 2033102 YER133W GLC7 SGTC_2313 7726885 200 µM 1.38698585663137 0.0658937115308993 no 260 0.0827230378004834 485 726423 SGTC_1009 4106-0057 9.87 µM 1.38667316233167 0.0659362201545868 no 261 0.0827707238771438 510 2928005 SGTC_1344 1488-0097 29.1 µM 1.384067719066 0.0662912387496749 no 262 0.0831688600927916 492 747966 SGTC_3234 9132280 49.47 µM 1.38259674422516 0.0664923270813345 no 263 0.08339427396276 512 17612295 SGTC_223 busulfan 5 mM 1.38078051690898 0.0667412639506572 no 264 0.0836732278756102 388 2478 A DNA alkylator. SGTC_1970 st070122 35.8 µM 1.37861276100793 0.0670393256091872 no 265 0.0840070899645665 501 102928 SGTC_4 0960-0234 25.671 µM 1.37331543156231 0.067772028115099 no 266 0.08482715365498 459 6821112 SGTC_3249 9135183 49.47 µM 1.37000602507009 0.0682328997741272 no 267 0.0853425104347423 516 4902779 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.36675092555839 0.0686885645145045 no 268 0.0858516947951927 582 551469 SGTC_1779 st039427 55 µM 1.36603353206188 0.0687893036312425 no 269 0.0859642194243597 595 1124498 SGTC_798 1287-0182 476 µM 1.36309002132601 0.0692038355345935 no 270 0.0864270706301098 548 1649755 SGTC_704 1310-0270 142 µM 1.36041745842479 0.0695818747348413 no 271 0.0868489284240758 525 5718033 SGTC_3102 9121669 49.47 µM 1.35925743159327 0.0697464568100268 no 272 0.0870325140142904 446 41905072 SGTC_3064 1327-0027 10 µM 1.35712388742793 0.0700499415649638 no 273 0.0873709247988589 337 16000455 YPR107C YTH1 SGTC_1620 st003704 16.5 µM 1.35516171537279 0.0703299454559928 no 274 0.087683019690844 499 2834414 SGTC_960 1222-0186 7.7 µM 1.35501503901071 0.0703509108400302 no 275 0.0877063827884844 528 3126296 SGTC_1284 0929-0043 16 µM 1.35238588165059 0.0707275286082059 no 276 0.0881259517561615 528 1239883 SGTC_1408 3909-7976 48.8 µM 1.35007630245916 0.0710596444514467 no 277 0.0884957544253973 566 24152374 SGTC_182 3448-4371 550.524 µM 1.34676348703908 0.0715381142782416 no 278 0.0890282089113812 540 3491403 SGTC_1830 st055982 50.3 µM 1.34296040147223 0.0720904374109666 no 279 0.0896423981808279 519 455313 An antimicrobial agent. SGTC_2235 salicylic acid 500 µM 1.34251315686698 0.0721556051018082 no 280 0.0897148336514189 487 338 A COX inhibitor and kinase inhibitor. SGTC_1260 0700-1617 7.75 µM 1.33877790191022 0.0727016309749639 no 281 0.0903214933887345 568 2853078 SGTC_990 3985-0011 41.3 µM 1.33612852346077 0.0730908356984549 no 282 0.0907536342027581 463 5399565 YGL099W LSG1 SGTC_1540 guanosine 70.6 µM 1.33473695038809 0.0732959012422581 no 283 0.0909812277443618 474 6802 Guanosine is a purine nucleoside SGTC_1814 st052110 31.539 µM 1.33240957979689 0.0736398513383997 no 284 0.0913628179312287 483 674163 SGTC_826 1683-5028 118 µM 1.32875807802129 0.074181972813304 no 285 0.0919638985335839 507 722377 SGTC_449 xestospongin c 11.1929 µM 1.32809673171737 0.0742804850402183 no 286 0.0920730765149885 561 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1101 ebselen 5.29 µM 1.32675419631966 0.0744807724283051 no 287 0.0922950033012381 563 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_67 0335-0847 266 µM 1.3266705603323 0.0744932633689698 no 288 0.0923088417726631 682 4552207 YOR254C SEC63 SGTC_130 0136-0219 337.655 µM 1.32625049102544 0.0745560244349419 no 289 0.092378369972497 535 234244 SGTC_1548 st061468 90.8 µM 1.32352760415042 0.0749638204165797 no 290 0.092829991343263 535 390799 SGTC_2695 st077686 51.995 µM 1.3234662988646 0.074973021411003 no 291 0.0928401782724321 488 2876092 SGTC_2891 9063876 19.48 µM 1.32227415796189 0.0751521149801959 no 292 0.0930384373678924 446 6472478 SGTC_3313 9133968 57.047 µM 1.3195377665853 0.0755644325475861 no 293 0.093494696415052 555 1494643 SGTC_885 0865-0106 16.8 µM 1.31601513074368 0.0760977557951734 no 294 0.0940844821266798 531 2793380 SGTC_439 amiodarone 34.4 µM 1.31483425281029 0.0762771792517952 no 295 0.0942828064925052 596 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2513 baicalein 25.65 µM 1.31110550945305 0.0768458406720862 no 296 0.0949110598283206 531 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_665 3914-0008 307 µM 1.31110495759999 0.0768459250717221 no 297 0.0949111530373716 532 1069549 SGTC_1209 2323-2347 50.3 µM 1.31100138139506 0.0768617671194455 no 298 0.0949286484529861 512 5412760 SGTC_1924 st058459 75.1 µM 1.30891703393503 0.077181097374426 no 299 0.0952812279604714 505 688683 SGTC_1212 0520-0165 585 µM 1.30164147656673 0.0783036443199324 no 300 0.0965194871033839 546 5403258 SGTC_563 tetrahydrosecaminediol 614 µM 1.29856486206799 0.0787820434916191 no 301 0.0970466516309295 576 334274 A psychoactive constituent of the cannabis plant. SGTC_306 1672-3436 11.6 µM 1.29646228617268 0.0791102559139183 no 302 0.0974081325812621 567 6797378 SGTC_2076 5212012 200 µM 1.28906045077745 0.0802739248077861 no 303 0.0986885357667607 442 604802 SGTC_2629 bisabolol 100 µM 1.28813487945243 0.0804203424111751 no 304 0.0988495078114776 586 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_293 4049-0273 38.5 µM 1.28659475443538 0.0806644243256942 no 305 0.099117786498677 514 1380311 SGTC_1217 1183-1422 255 µM 1.28528180255906 0.0808729448346496 no 306 0.0993469134236715 587 2849664 SGTC_443 clozapine 122 µM 1.28438145450086 0.0810161714310271 no 307 0.0995042593528153 471 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2948 9070189 9.45 µM 1.27442101000786 0.0826134671305673 no 308 0.10125712514014 500 6473636 YDL196W YDL196W SGTC_2998 9066762 71.4286 µM 1.27407002744856 0.0826701813270648 no 309 0.101319299779086 622 4945196 SGTC_884 0851-0618 334 µM 1.27324698453085 0.0828032892231474 no 310 0.101465206400337 609 9642473 SGTC_385 1494-0393 12.4 µM 1.27008487168939 0.0833161869831083 no 311 0.102027199915753 578 3090647 SGTC_2282 7944268 200 µM 1.26987285678432 0.0833506612498783 no 312 0.102064961597922 593 2970414 SGTC_1480 1070-0044 41.2 µM 1.26972240289472 0.0833751320125931 no 313 0.102091764900564 567 3124987 SGTC_1525 8-methoxypsoralen 92.5 µM 1.26882218800707 0.0835216614314449 no 314 0.102252244833499 641 4114 Related to psoralen; DNA damaging agent. SGTC_958 1222-0007 33 µM 1.26612454315762 0.0839619202610939 no 315 0.10273424847925 626 7312461 SGTC_403 arphamenine a 50 µM 1.26496601879723 0.08415152680671 no 316 0.102941754725684 580 5487158 An arginine aminopeptidase inhibitor. SGTC_2750 bromebric acid 70.15 µM 1.26457460186683 0.0842156595162538 no 317 0.103011931177581 634 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_812 4251-0442 148 µM 1.26326740891796 0.0844301057362887 no 318 0.103246547306699 559 5723007 SGTC_1243 0416-0003 5.65 µM 1.26253627395636 0.0845502276351882 no 319 0.1033779411195 563 2141977 SGTC_988 1497-1057 103 µM 1.25799348280008 0.0852994603951835 no 320 0.104197056607625 577 3533044 SGTC_1058 3448-5425 97.3 µM 1.25005698901776 0.0866203273481079 no 321 0.105639365045629 575 7279705 SGTC_3244 9134489 49.47 µM 1.24991115294031 0.0866447410189153 no 322 0.105666002402181 578 16584271 SGTC_1793 st048256 72.231 µM 1.24476084279261 0.0875102294172676 no 323 0.106609836823908 562 672022 SGTC_335 4077-0256 27.6 µM 1.24083302658082 0.0881746071551346 no 324 0.107333718961338 659 3121989 SGTC_1289 0976-0073 69.1 µM 1.24017608851411 0.0882860922113098 no 325 0.107455135298804 626 3391136 SGTC_1831 st055328 12 µM 1.23850544024393 0.0885700812432924 no 326 0.107764353066908 613 1103068 SGTC_1887 st057648 70.8 µM 1.23767007372257 0.0887123379100329 no 327 0.107919209958683 594 688672 SGTC_886 0866-0150 153 µM 1.23664658569181 0.0888868621319734 no 328 0.108109158430457 620 271463 SGTC_912 3474-0017 2.18 µM 1.23594658668038 0.0890063724249267 no 329 0.108239209312716 611 3360550 SGTC_1728 st035614 33.7865 µM 1.23485154734426 0.0891935674878566 no 330 0.108442879433639 655 15945546 SGTC_1568 digitonin 820 nM 1.23267361859934 0.0895667511069303 no 331 0.108848779140462 652 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3126 9127922 49.47 µM 1.23066632893322 0.0899117231386411 no 332 0.109223843170343 597 45595682 SGTC_394 menadione 8.33 µM 1.23023735989213 0.0899855734856889 no 333 0.109304116734325 623 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_188 3229-0966 278.469 µM 1.22802082216228 0.0903678859422271 no 334 0.109719575798022 695 5722370 SGTC_624 k048-0052 28 µM 1.22693650866776 0.0905553490783658 no 335 0.109923227643564 573 6835531 SGTC_2226 7298446 200 µM 1.22642398454109 0.090644057978084 no 336 0.110019582427468 538 3283010 SGTC_2965 9082772 38.63 µM 1.22575413921313 0.0907600936232102 no 337 0.11014560500962 628 16459634 SGTC_928 2764-0428 58.7 µM 1.22172190431761 0.0914609174647932 no 338 0.110906404998616 635 662578 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.2189054105759 0.0919528129950574 no 339 0.111440047933224 608 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_290 2043-6722 48.1 µM 1.21724818123291 0.0922431591331852 no 340 0.111754901731366 606 773758 YLR208W SEC13 SGTC_586 0957-0265 8.15 µM 1.21427957988487 0.0927649528427079 no 341 0.11232049031508 523 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1464 k208-0027 110 µM 1.2136619219843 0.0928737929135352 no 342 0.11243842532714 634 X1464 SGTC_2256 7954252 200 µM 1.2132988146433 0.0929378216229933 no 343 0.112507797974741 512 2972920 SGTC_2874 9043904 71.43 µM 1.21127874387214 0.0932946276623383 no 344 0.112894296220604 500 4463428 SGTC_301 4119-0100 24.5 µM 1.20188625082343 0.0949669269251145 no 345 0.114703801061488 679 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2815 7968870 71.43 µM 1.20059769190737 0.0951980619567287 no 346 0.114953648407184 649 2977326 YHR190W ERG9 SGTC_2322 7413319 38.22 µM 1.19985545790417 0.0953313879429233 no 347 0.115097740715328 751 1840400 SGTC_697 0508-1955 564 µM 1.1976870202398 0.0957216873867692 no 348 0.115519442135092 677 6243113 SGTC_1270 0831-1170 17.3 µM 1.19748049642456 0.0957589210581068 no 349 0.115559662512674 682 6764716 SGTC_2255 7941087 197.44 µM 1.19597218894902 0.0960311732130592 no 350 0.115853706085178 708 935561 SGTC_428 3448-4153 16.5 µM 1.19548663907772 0.0961189368078486 no 351 0.11594847666856 542 3834874 SGTC_1156 4092-0367 4.88 µM 1.19506830561994 0.096194598249737 no 352 0.116030171947292 638 1357585 SGTC_2954 9074818 52.69 µM 1.19490659213499 0.0962238581198672 no 353 0.116061763511318 608 16648742 SGTC_1832 st054113 55 µM 1.19269527063078 0.0966246234477986 no 354 0.116494369260404 593 1251267 SGTC_545 4218-0007 221 µM 1.19227749862843 0.0967004751916574 no 355 0.116576227209413 602 2840508 SGTC_1783 st039459 87.517 µM 1.19120012623696 0.0968962874502509 no 356 0.116787515006925 697 729761 SGTC_2608 thymoquinone 42.66 µM 1.19013845626647 0.0970895304262843 no 357 0.116995988770074 572 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2802 7925815 54.55 µM 1.18975585593664 0.0971592398383459 no 358 0.117071182306182 639 1262923 SGTC_1211 1056-0033 32.3 µM 1.18958127156828 0.0971910611437997 no 359 0.117105505246092 654 6741922 SGTC_32 0928-0142 34.1 µM 1.18595413121843 0.0978539070975248 no 360 0.117820207101384 596 2244242 SGTC_164 4100-3994 89.624 µM 1.18591625346605 0.0978608465498824 no 361 0.117827686887952 703 4615967 SGTC_114 0364-0001 490.298 µM 1.18335119332218 0.0983316220528403 no 362 0.118334995871673 641 4003655 SGTC_846 0335-0850 148 µM 1.18330864603623 0.0983394448821171 no 363 0.118343423729995 606 6819598 SGTC_933 2914-0560 114 µM 1.1818352397122 0.0986106295747802 no 364 0.118635541057817 697 463887 SGTC_1305 1181-0477 144 µM 1.17423503778812 0.100018166522793 no 365 0.120150447710839 633 6252086 SGTC_1895 st058434 18.3 µM 1.17410359135699 0.100042638441987 no 366 0.120176767578497 671 5393175 SGTC_219 mitoxanthrone 164.414 µM 1.16966275145056 0.10087197850636 no 367 0.121068356784832 636 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2182 6325192 200 µM 1.16910591248417 0.100976322495829 no 368 0.121180481042854 627 736248 SGTC_2398 5228213 48.84 µM 1.163028974572 0.102120175777308 no 369 0.122408873433581 744 80771 YMR134W ERG29 SGTC_761 k216-0224 480 µM 1.16093081076867 0.102517291227268 no 370 0.122835018899552 703 1340404 SGTC_1422 4031-0024 15.5 µM 1.15853010102354 0.102973044807776 no 371 0.123323887569225 654 782427 SGTC_989 1501-0895 10.3 µM 1.15800450882429 0.103073019945264 no 372 0.123431098211788 648 2830112 SGTC_1011 4112-3381 17.4 µM 1.15593945686887 0.103466504942703 no 373 0.123852960996942 663 2877139 SGTC_762 1165-0429 115 µM 1.15422697451683 0.103793635660428 no 374 0.124203563164449 654 5967793 SGTC_1434 4073-0095 163 µM 1.15328574191394 0.103973755889755 no 375 0.124396560215242 689 24133745 SGTC_1123 mangostin 811.285 nM 1.14889616228562 0.104816767449223 no 376 0.125299400153849 636 5281650 An antioxidant. SGTC_1760 st045453 10.4495 µM 1.14371456061382 0.105818241480726 no 377 0.126371016420949 691 3323419 YIL048W NEO1 SGTC_1555 citronellol 128 µM 1.14310244074135 0.105937004200603 no 378 0.12649803052112 632 8842 A terpine precursor. SGTC_3262 9137218 49.47 µM 1.13897119344688 0.106741063038205 no 379 0.127357584668259 517 17650664 SGTC_1791 st048313 56.1 µM 1.13152566338274 0.108201279375068 no 380 0.128916954050949 620 1204976 SGTC_699 0375-0592 111 µM 1.13032602649353 0.108437890581993 no 381 0.129169435820879 709 762578 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.12921179682269 0.108657989693589 no 382 0.129404249219707 621 15053 SGTC_2741 miltefosine 3.04 µM 1.12905988974488 0.108688021495104 no 383 0.129436285101943 576 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1634 st006576 41 µM 1.12861173007532 0.108776656773012 no 384 0.12953083010088 677 3915356 SGTC_466 geldanamycin 89.2 µM 1.12790246305734 0.108917039047849 no 385 0.129680556781422 550 5288382 HSP90 inhibitor. SGTC_1233 0325-0408 14.2 µM 1.12454356251668 0.109583621205522 no 386 0.130391250410185 683 12874 SGTC_1644 st010134 20.9 µM 1.11973929362922 0.110542123845623 no 387 0.131412437636704 658 3818134 SGTC_1649 st011737 51.3 µM 1.11968722930546 0.110552544044094 no 388 0.131423534500444 683 1761035 SGTC_1354 1498-1681 81 µM 1.11929210607918 0.110631647294291 no 389 0.131507771191907 732 5754243 SGTC_2125 5246583 200 µM 1.1178524815335 0.110920201739965 no 390 0.131815001337504 785 835267 SGTC_3010 9080089 71.4286 µM 1.11775505189262 0.110939749733549 no 391 0.131835811663841 699 17027233 SGTC_26 0302-0163 425.158 µM 1.11526865925408 0.111439447473117 no 392 0.132367655746127 698 3100915 SGTC_2150 5556613 200 µM 1.11426349790978 0.111641914296814 no 393 0.132583080810777 723 743190 SGTC_1357 1503-1303 39.5 µM 1.1128181258061 0.111933512618054 no 394 0.132893274527957 729 292895 SGTC_5 0352-0601 109.883 µM 1.11268464497124 0.111960469313 no 395 0.132921946256026 655 762456 SGTC_524 r073-0010 27.8 µM 1.11135237346384 0.112229778347002 no 396 0.133208352021746 683 2772106 SGTC_1035 k081-0041 55.2 µM 1.11115409656962 0.112269898129708 no 397 0.133251012976801 726 731709 SGTC_1301 naphtanilide LB 4.81 µM 1.11071274042126 0.112359239899923 no 398 0.133346008244885 741 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2413 inermin 26.06 µM 1.10905457630045 0.112695348633976 no 399 0.133703319385241 728 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_415 dibenzyl ketone 100 µM 1.10885408663125 0.112736036355043 no 400 0.133746566664875 727 7593 SGTC_133 0724-0033 378.92 µM 1.10761441575703 0.112987850263576 no 401 0.134014187478206 666 280309 SGTC_425 3825-7017 13.1 µM 1.10646478953664 0.113221731966426 no 402 0.134262698023662 737 3397440 SGTC_3209 9113616 49.47 µM 1.10507756085078 0.113504411463489 no 403 0.13456299137164 744 16649353 SGTC_222 nsc-310342 10.666 µM 1.10478225300155 0.113564652088637 no 404 0.134626976122484 602 432556 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.10443633042913 0.113635246731304 no 405 0.134701954186811 688 6710655 SGTC_156 3474-0145 5.642 µM 1.1010308360077 0.114331898264387 no 406 0.135441618391658 719 2265471 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.09991869038587 0.114560063830912 no 407 0.13568377521499 737 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3356 9151811 4.48 µM 1.09978717390946 0.114587066900443 no 408 0.135712431000791 693 1859254 YPR165W RHO1 SGTC_1686 st019653 115.5 µM 1.09951679338178 0.114642595878337 no 409 0.135771356537283 711 97252 SGTC_1191 1487-1166 10.6 µM 1.09858369823759 0.114834375901583 no 410 0.135974845735854 798 3955771 SGTC_468 gf-109203x 121 µM 1.09622335554921 0.115320518154312 no 411 0.136490520548218 574 2396 A protein kinase C inhibitor. SGTC_2659 sanguinarine 24.21 µM 1.09341586493294 0.115900658647452 no 412 0.137105625487834 699 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_155 k072-0202 43.6 µM 1.09307821485961 0.115970570086288 no 413 0.137179730042418 681 5857737 SGTC_1996 st072960 66.8 µM 1.09277072548971 0.116034262705275 no 414 0.137247238982585 749 1719405 SGTC_2977 9011197 71.43 µM 1.08617163976881 0.117407170454498 no 415 0.138701530990091 644 2704722 SGTC_2935 9038016 29.96 µM 1.08533592733077 0.117581853585484 no 416 0.138886449531801 766 6463195 SGTC_1269 0831-0796 3.05 µM 1.08382982398464 0.11789712824668 no 417 0.139220129550293 732 927758 SGTC_3032 9089427 49.47 µM 1.08307007603855 0.118056394069861 no 418 0.139388659976133 685 17173707 SGTC_3190 9110366 49.47 µM 1.08077280310147 0.118538896529257 no 419 0.139899094577568 598 17123768 SGTC_2361 9034121 116 µM 1.08067928595617 0.118558567665918 no 420 0.139919900171026 693 6496917 SGTC_2883 9059145 45.46 µM 1.07809570396795 0.119102931180466 no 421 0.140495524311107 682 16476510 SGTC_1142 3253-1408 9.78 µM 1.0759826684446 0.119549459976966 no 422 0.140967503843718 721 256655 SGTC_3144 9087057 49.47 µM 1.07577492645044 0.119593423898685 no 423 0.141013964263875 706 17249618 SGTC_3042 9091578 49.47 µM 1.07430017139206 0.119905850491525 no 424 0.141344084126301 700 25236497 SGTC_2698 st077697 67.5 µM 1.07402653645648 0.119963883230442 no 425 0.141405394121161 678 3154499 SGTC_2988 9073640 71.4286 µM 1.07340606245184 0.120095547243142 no 426 0.141544482817522 680 9102229 SGTC_2975 9084847 53.72 µM 1.07067296647015 0.120676719839111 no 427 0.142158251094475 751 27211724 SGTC_1692 fluoroquinolonic acid 71 µM 1.07007662345439 0.12080379045595 no 428 0.142292410193179 716 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3219 9131112 49.47 µM 1.0681500771232 0.121214948373923 no 429 0.142726409971889 711 17612988 YMR079W SEC14 SGTC_2102 5377816 72.7585 µM 1.06514311363901 0.12185865092184 no 430 0.143405585822197 777 1379702 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.06185068233924 0.122566213642904 no 431 0.144151738519763 826 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_742 0kpi-0133 140 µM 1.0611364553758 0.122720084897562 no 432 0.144313946275904 781 2728852 SGTC_2482 5981709 142.65 µM 1.05938187834087 0.123098661664188 no 433 0.1447129496341 764 877755 SGTC_2780 5215298 71.43 µM 1.05695059108774 0.123624600882419 no 434 0.145267068784202 792 2834131 SGTC_570 0987-0065 62.6 µM 1.05109544235252 0.124897646049847 no 435 0.14660737856273 652 3104428 SGTC_1828 st055811 49 µM 1.05071441856714 0.12498080570821 no 436 0.146694885903381 725 5877589 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.05046042697639 0.125036261664788 no 437 0.146753238021588 723 5355888 SGTC_1799 st045822 46.1415 µM 1.04848515134379 0.125468125535509 no 438 0.147207569992406 744 3674992 SGTC_1013 4112-3890 241 µM 1.04798488210321 0.125577666792994 no 439 0.147322786101843 752 705171 SGTC_3271 9137798 49.47 µM 1.04629074071993 0.125949119375706 no 440 0.147713409536509 678 6498326 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.04553244901663 0.126115628213988 no 441 0.147888475717822 796 5393153 SGTC_112 phenothiazine 287.218 µM 1.0455234945428 0.126117595390826 no 442 0.147890543859312 785 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2704 st078022 71.1 µM 1.04493224877892 0.12624753142821 no 443 0.148027141898331 780 54697681 SGTC_1896 st058441 89 µM 1.04481706982844 0.126272854762203 no 444 0.14805376200846 693 688759 SGTC_1222 0366-0074 1.18 µM 1.04445743909944 0.126351946236579 no 445 0.148136900328133 818 286520 SGTC_3148 9097893 49.47 µM 1.04318087938092 0.126632971229362 no 446 0.148432263672091 695 17174100 SGTC_132 0417-1715 25.805 µM 1.0419191162159 0.126911166358407 no 447 0.148724590246465 792 6769098 SGTC_1151 3909-8316 15.3 µM 1.0413663708284 0.12703317026475 no 448 0.148852771991557 762 800431 SGTC_739 1486-1183 203 µM 1.04120994329172 0.127067712314801 no 449 0.148889060961334 796 4346692 SGTC_3067 9117431 49.47 µM 1.0411529369369 0.127080301981425 no 450 0.14890228709666 706 17150885 SGTC_1640 st009078 66.4 µM 1.04017890075063 0.127295548813316 no 451 0.149128396088529 687 690618 SGTC_875 0709-0210 25.7 µM 1.03835792432677 0.127698636214189 no 452 0.149551725316929 815 6251364 SGTC_318 1488-0629 67.2 µM 1.03311514274933 0.128864118227188 no 453 0.150775008844655 737 3662576 SGTC_417 st075190 100 µM 1.03197453896478 0.129118651124996 no 454 0.151042022575362 800 222757 SGTC_1424 4048-1941 275 µM 1.03111449081274 0.129310806630894 no 455 0.151243566592345 853 X1424 SGTC_1348 1493-0373 93.8 µM 1.03037393590388 0.129476423192351 no 456 0.151417251786842 769 3010129 SGTC_228 caffeine 993.056 µM 1.02741581431217 0.13013943866541 no 457 0.152112354000414 728 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2309 7664088 163.95 µM 1.02540288282234 0.130591946083548 no 458 0.152586564251772 836 704922 SGTC_1794 st048918 76.9 µM 1.02091815111136 0.13160402338152 no 459 0.153646609356516 708 672303 SGTC_3224 9130643 49.47 µM 1.01425388294496 0.133117937124402 no 460 0.155230811698741 745 17644395 SGTC_3034 9090421 49.47 µM 1.01406240872862 0.133161610509119 no 461 0.155276486934024 751 17173761 SGTC_2706 st078239 82.5 µM 1.01322567876674 0.133352576070846 no 462 0.155476188830326 794 15434492 SGTC_1362 1611-0397 101 µM 1.01298209837482 0.133408203428907 no 463 0.155534355863968 773 27816 SGTC_2896 9052656 71.43 µM 1.01290759262357 0.133425221771292 no 464 0.155552150715172 856 6469436 SGTC_280 3448-3607 3.04 µM 1.01181806199293 0.133674259130239 no 465 0.155812526129111 815 626179 SGTC_2185 6113692 200 µM 1.01132656090262 0.13378670758056 no 466 0.155930078783339 727 874150 SGTC_1646 st011709 75.6 µM 1.00859305173028 0.134413281863088 no 467 0.156584920492941 754 5757843 SGTC_2722 naftopidil 47.16 µM 1.00265225784573 0.135781968333255 no 468 0.158014336246021 814 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_535 2293-4129 48.2 µM 1.00261903127502 0.135789650075175 no 469 0.158022354913253 882 396118 YIL048W NEO1 SGTC_2640 pentamidine 10.38 µM 1.00258160042236 0.135798304173057 no 470 0.15803138853234 859 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2041 5107442 45.335 µM 1.00194566562601 0.135945391461649 no 471 0.15818491781394 808 793005 SGTC_2915 7971052 15.16 µM 1.00018753900453 0.136352601378557 no 472 0.158609879237817 637 5741558 SGTC_2843 9000894 45.46 µM 0.999145321887115 0.136594388915113 no 473 0.158862149390395 652 2242070 SGTC_1903 st060211 78.3 µM 0.999102978958261 0.136604218390996 no 474 0.158872404113301 841 688960 SGTC_621 3584-0052 32.1 µM 0.998933957570484 0.136643459788489 no 475 0.158913342483856 844 2273927 SGTC_2831 7999036 19.48 µM 0.996405670602829 0.137231367761747 no 476 0.159526539451037 852 2988270 SGTC_2916 7875993 68.79 µM 0.994856854310688 0.137592369486376 no 477 0.159902944904544 805 1299250 SGTC_2647 atorvastatin 60.16 µM 0.994584880821227 0.137655828549487 no 478 0.159969101941317 791 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3132 9126706 49.47 µM 0.992660034075813 0.138105520348465 no 479 0.160437828843928 777 850858 SGTC_882 0843-0131 351 µM 0.989120862771514 0.138934970163618 no 480 0.161302005664092 862 5425421 SGTC_1039 k821-0043 94 µM 0.988403088459758 0.139103602546533 no 481 0.161477637776104 838 15992768 SGTC_1815 st051655 58.2 µM 0.988191796836775 0.139153269484963 no 482 0.161529362445285 812 5984156 SGTC_1559 coumarin 343 70.1 µM 0.986498612291346 0.139551711159417 no 483 0.161944247941106 776 108770 A hepatotoxic, DNA x-linker. SGTC_2038 4100038 30.985 µM 0.985779387423667 0.139721194348305 no 484 0.162120691397047 816 3596803 SGTC_1084 voriconazole 435 nM 0.983136763534818 0.140345122132065 no 485 0.162770066296148 842 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_57 miconazole 162.5 nM 0.982638780162864 0.140462908348622 no 486 0.162892625470249 783 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1801 st050089 28.441 µM 0.982010125279136 0.140611697644297 no 487 0.163047430001537 907 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1404 3909-7820 48.3 µM 0.980754279924964 0.140909249846079 no 488 0.16335696468984 814 23741373 SGTC_1412 3909-8563 178 µM 0.979882052827516 0.141116161094347 no 489 0.163572171491659 916 23767530 SGTC_1008 4106-0037 6 µM 0.976621236114541 0.141891521994917 no 490 0.164378350873787 822 2905394 SGTC_1645 Cervolide 78 µM 0.975619960550583 0.142130184284839 no 491 0.164626414627284 781 23173 A fragrance. SGTC_2165 5727197 32.143 µM 0.975224213445791 0.142224588742548 no 492 0.164724526925771 767 1361712 SGTC_286 k060-0067 22.9 µM 0.975202161292133 0.142229850475079 no 493 0.164729995135944 812 5985051 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.975038610983001 0.142268878347647 no 494 0.164770553913803 881 676296 Flavone; oxidizing agent. SGTC_1575 cyproterone acetate 48 µM 0.972035395672384 0.142986821343906 no 495 0.165516469965523 797 9880 An androgen receptor antagonist and liver toxin. SGTC_1090 efavirenz 20.7 µM 0.970540355309983 0.143345134029995 no 496 0.165888609872171 839 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2457 5731572 11.68 µM 0.969608554306348 0.143568762964206 no 497 0.166120823676392 849 2865357 SGTC_2825 7998094 58.44 µM 0.968005503051914 0.143954040358648 no 498 0.166520810680551 789 2987815 SGTC_1979 st071809 45.3 µM 0.966202393362708 0.144388232428285 no 499 0.166971457754992 856 4976333 SGTC_897 1000-0139 31.4 µM 0.964762784248274 0.14473552590459 no 500 0.16733182010524 843 6151020 SGTC_1747 st037496 66.6 µM 0.964231447013726 0.144863848525993 no 501 0.167464950763099 853 723305 SGTC_3070 9117005 49.47 µM 0.964056850311179 0.144906031884205 no 502 0.16750871221142 797 8779016 SGTC_384 k007-0144 5.16 µM 0.95814516198485 0.146339203978569 no 503 0.168994782502131 870 6824886 SGTC_180 1486-1293 102.781 µM 0.956487775039062 0.146742707124327 no 504 0.169412928880562 860 4140536 SGTC_844 0330-0132 15.3 µM 0.954011279614089 0.147347018098784 no 505 0.170038966409296 900 2828079 SGTC_1405 3909-7894 12 µM 0.952420163795789 0.147736158751613 no 506 0.170441968670438 857 7104060 SGTC_857 0438-0306 1.35 µM 0.952291538052398 0.147767646906801 no 507 0.170474574060271 856 4686136 SGTC_1992 st073643 23.3 µM 0.95129748196923 0.148011147832789 no 508 0.170726692429159 827 3161292 SGTC_1643 st009866 20.2 µM 0.94962786270665 0.148420736691773 no 509 0.171150687870135 867 3156273 YOR207C RET1 SGTC_3063 1327-0034 4 µM 0.949070522977641 0.148557631157208 no 510 0.171292372617553 831 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2491 paeonol 100 µM 0.947931357503504 0.148837696917936 no 511 0.171582200047769 832 11092 Increases levels of cortical cytochrome oxidase. SGTC_1508 1080-0625 72.9 µM 0.944938658856094 0.14957513702256 no 512 0.172345096745506 813 767111 SGTC_3352 9151559 45.5865 µM 0.942968126045339 0.150062031138363 no 513 0.172848603281444 829 17159339 SGTC_773 4358-1457 44.6 µM 0.942406324235703 0.150201038725548 no 514 0.172992325298808 922 1186886 SGTC_279 1273-0055 2.93 µM 0.941180720672398 0.150504589683466 no 515 0.173306127434642 928 2847562 SGTC_2175 5807670 165.306 µM 0.94002370347047 0.150791528270029 no 516 0.173602701146598 855 241186 SGTC_1994 st072947 40.9 µM 0.936788640799923 0.151595750801849 no 517 0.174433644746323 869 5286565 YDL195W SEC31 SGTC_3080 9117754 49.47 µM 0.936357401112612 0.151703170084792 no 518 0.174544601554341 932 9550191 SGTC_2005 4024620 188 µM 0.936033491236029 0.151783887399927 no 519 0.17462797216257 865 236743 SGTC_569 4130-2812 160 µM 0.932321679198629 0.152710896295289 no 520 0.175585153605956 774 743552 SGTC_2462 5162487 171.77 µM 0.931013026199708 0.153038620226916 no 521 0.175923413010916 896 2259986 SGTC_1715 st032160 10.2275 µM 0.929610225027179 0.153390438899958 no 522 0.17628646569157 839 5289825 SGTC_975 1335-0046 28.5 µM 0.928259239983094 0.153729768293025 no 523 0.176636555898509 870 16486740 SGTC_181 1447-1644 8.07 µM 0.926933359794603 0.154063274868182 no 524 0.176980567650607 894 534600 SGTC_2533 agelasine 13.65 µM 0.926815443243571 0.154092958284123 no 525 0.177011182665404 906 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1570 verbenone 133 µM 0.925516690651773 0.154420146695807 no 526 0.177348602921122 903 29025 A natural terpanoid with antifungal properties. SGTC_2348 9022543 33.42 µM 0.923940298171364 0.1548178961998 no 527 0.17775870017363 896 3162678 YDL140C RPO21 SGTC_3020 9089140 49.47 µM 0.921323504697316 0.155479648756782 no 528 0.178440776518318 887 17217859 SGTC_332 4112-0506 40.9 µM 0.919272912971071 0.155999518647636 no 529 0.178976421032278 882 2790355 SGTC_2483 5729050 27.16 µM 0.919118710572311 0.15603865859411 no 530 0.179016741814085 969 2865180 SGTC_3056 9094900 49.47 µM 0.918914281780886 0.156090557075556 no 531 0.17907020458351 874 25236784 SGTC_2377 9073351 62.6 µM 0.918702174473909 0.156144416929574 no 532 0.179125686076087 847 7337946 YHR072W ERG7 SGTC_1676 st018489 23.4 µM 0.918404496324999 0.156220026213806 no 533 0.179203568804767 873 3696235 SGTC_3011 9081274 71.4286 µM 0.918198840666639 0.156272276169838 no 534 0.179257387758131 921 6625322 SGTC_1854 st056233 32.9 µM 0.917950444369275 0.156335400384573 no 535 0.179322405253018 863 5393174 SGTC_1436 4092-1007 8.32 µM 0.913498443987635 0.157469621735815 no 536 0.18049022579118 893 2881121 SGTC_3323 9138564 53.9225 µM 0.908857179942873 0.158657804663577 no 537 0.181712759559703 982 43912313 YNL103W MET4 SGTC_1804 st050076 49.1 µM 0.907398492049462 0.159032445772674 no 538 0.182098053288553 889 3895976 SGTC_2118 5526350 200 µM 0.906384632333056 0.159293180897485 no 539 0.182366151971918 919 743594 SGTC_1066 ketoconazole 628 nM 0.905702269581187 0.159468822196451 no 540 0.182546730457509 954 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_3354 9151612 71.43 µM 0.90478472085261 0.159705200534313 no 541 0.182789723851155 934 27261949 SGTC_631 k072-0230 41.5 µM 0.901079086860323 0.160662175114142 no 542 0.183773135687182 935 5773147 SGTC_684 1140-0066 328 µM 0.897897269837895 0.161486856925307 no 543 0.18462016016872 934 6813534 SGTC_2286 7945697 125 µM 0.896510133149579 0.16184724547969 no 544 0.184990185392335 906 1245733 SGTC_3018 9082602 49.47 µM 0.896439687081338 0.16186556187037 no 545 0.185008989498557 943 17332089 SGTC_1889 st059080 5.18 µM 0.89637235318714 0.161883070339896 no 546 0.18502696398493 959 176925 Isolated from Daphnopsis sellowiana. SGTC_1842 st055362 61.2 µM 0.895443551142641 0.162124707619382 no 547 0.185275014288342 965 676032 SGTC_2617 dihydrotanshinone i 20.83 µM 0.893719657535774 0.162573818251047 no 548 0.185735952524022 946 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1088 bifonazole 369 nM 0.893254886837298 0.162695039219809 no 549 0.18586034551979 899 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.893094976004127 0.16273676057373 no 550 0.185903156606517 1004 688801 SGTC_967 1306-0166 352 µM 0.893027516665336 0.162754363062563 no 551 0.185921218552623 922 4437607 SGTC_3061 glucosamine 200 µM 0.892538662240231 0.162881959192845 no 552 0.186052139722885 908 91431 and experimental redox chemotherapeutic SGTC_2904 7225135 42.03 µM 0.891638118596433 0.163117180753388 no 553 0.186293465849544 974 4446116 SGTC_1306 1185-0270 9.02 µM 0.891418221083398 0.163174651396216 no 554 0.186352423053 957 1548076 SGTC_1476 4112-3294 3.34 µM 0.891314834522636 0.163201676222076 no 555 0.186380146244567 948 704369 SGTC_2159 5658611 73.75 µM 0.890873071346361 0.163317184079981 no 556 0.186498634184994 957 793844 SGTC_3107 9121808 49.47 µM 0.890812301215426 0.16333307780626 no 557 0.186514937354248 901 662681 SGTC_2273 7815444 169.05 µM 0.890682209208297 0.163367105246943 no 558 0.186549840887995 918 2824616 SGTC_1758 st042942 75.2445 µM 0.888226166127608 0.164010382793962 no 559 0.187209553212757 922 669317 SGTC_1631 benzylvanillin 81.9 µM 0.886138506061158 0.164558465161985 no 560 0.187771447826184 906 75506 SGTC_515 4092-1064 102 µM 0.885915591517764 0.164617057931709 no 561 0.187831506860591 997 717353 SGTC_1499 4480-0877 67.3 µM 0.884952922991622 0.164870249210646 no 562 0.188091011268708 877 2861909 SGTC_184 1494-0393 24.714 µM 0.883033110884748 0.165375931260271 no 563 0.188609191026831 905 3090647 SGTC_472 calcifediol 10 µM 0.882187496254101 0.165598985728098 no 564 0.188837711252807 858 5283731 A vitamin D metabolite. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.88198856360304 0.165651488025569 no 565 0.188891495904972 977 23665772 A membrane-active detergent. SGTC_11 0438-0307 1.3 µM 0.880255335637613 0.166109376848905 no 566 0.189360501322039 930 4011476 SGTC_2683 piperine 63.03 µM 0.875527031689941 0.167362666639085 no 567 0.190643604308922 907 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_534 k292-0788 63.4 µM 0.875050785204174 0.167489238023933 no 568 0.190773136790852 1022 4146317 SGTC_2814 7977482 42.97 µM 0.873469722301053 0.167909877057166 no 569 0.191203551235789 986 6456762 SGTC_2738 aclarubicin 5.55 µM 0.872865849483733 0.168070715680494 no 570 0.1913681011708 856 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2523 spermine 47.74 µM 0.872070687088518 0.168282654536398 no 571 0.19158490813363 940 1103 A DNA binding polyamine. SGTC_2303 7774051 200 µM 0.870777495121858 0.168627702822534 no 572 0.191937827748327 911 2953184 SGTC_2670 beta-carotene 100 µM 0.868080942585535 0.16934865615074 no 573 0.192675011516459 905 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2330 7979373 200 µM 0.86770229529798 0.169450049894995 no 574 0.192778664504462 917 1863007 SGTC_2363 9053361 176 µM 0.867648198234529 0.16946453912554 no 575 0.192793476112558 967 6469797 YMR079W SEC14 SGTC_3339 9145883 14.936 µM 0.867127057760833 0.169604160885165 no 576 0.192936198364011 892 2030670 SGTC_2276 7947513 42.08 µM 0.866260397733763 0.169836516145112 no 577 0.193173689244403 905 2105100 SGTC_1283 0922-0125 16.4 µM 0.865171618077777 0.170128711770804 no 578 0.193472300362235 1000 3360884 SGTC_3194 9111903 49.47 µM 0.863925036396948 0.170463652028888 no 579 0.193814536162635 934 17087251 SGTC_2103 5378138 10 µM 0.863519499717336 0.170572705424838 no 580 0.193925951468278 1027 244142 SGTC_1554 st069299 38.7 µM 0.863436380260511 0.17059506270078 no 581 0.193948792149319 962 24207999 SGTC_3062 9077494 49.47 µM 0.86188590389048 0.171012450057338 no 582 0.194375153324593 926 16459633 SGTC_1242 0402-0103 60.1 µM 0.860450096404138 0.17139955067133 no 583 0.194770490480682 908 432868 SGTC_2983 9022671 12.99 µM 0.858886154972533 0.171821833565728 no 584 0.195201664286088 931 6405161 SGTC_3251 9135047 49.47 µM 0.851831290214146 0.173734980986946 no 585 0.197153868408864 959 17682963 SGTC_297 0986-0032 24 µM 0.848836439876439 0.174551209843331 no 586 0.197986155182152 949 2847425 SGTC_3139 9095020 49.47 µM 0.848252986864763 0.174710509517567 no 587 0.198148546882081 809 25236292 SGTC_147 4466-0538 29.23 µM 0.848016746366826 0.174775036300441 no 588 0.198214322250976 1085 6742687 YHR072W ERG7 SGTC_367 0335-0881 7.1 µM 0.847899455292211 0.174807078830259 no 589 0.198246983967998 972 23828853 SGTC_1 0258-0098 57.368 µM 0.844039772533688 0.175863578066042 no 590 0.199323590494922 861 6790032 YDR047W HEM12 SGTC_1785 bathophenanthroline 24 µM 0.842857138862923 0.176188104520765 no 591 0.19965417355894 935 72812 An iron chelator. SGTC_193 1273-0060 1.558 µM 0.842795443216815 0.176205044816357 no 592 0.199671428469122 875 2847393 YHR072W ERG7 SGTC_1648 st011736 69.8 µM 0.841940478349184 0.176439905871712 no 593 0.199910635626763 968 2855514 SGTC_1277 0873-0036 22 µM 0.840887707170399 0.176729376748794 no 594 0.200205422844415 1020 5965735 SGTC_1795 st049545 62.3 µM 0.839130877663226 0.177213104267141 no 595 0.200697935260399 990 5291882 SGTC_1393 3470-5649 58.2 µM 0.838606333541526 0.177357694825066 no 596 0.200845127684816 878 4108395 SGTC_1059 3448-6867 171 µM 0.83788006878901 0.177558012588153 no 597 0.201049031879442 1010 3934407 SGTC_832 4083-0019 164 µM 0.837264766723595 0.177727836400176 no 598 0.201221879602803 1131 1990758 SGTC_2678 equilin 100 µM 0.8370830040077 0.177778022640933 no 599 0.20127295656137 1029 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1875 nocodazole 6 µM 0.836973897207032 0.177808152255335 no 600 0.201303620286933 998 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2771 fluoxetine 41.05 µM 0.835949962758584 0.178091066548371 no 601 0.201591526552933 962 3386 A selective serotonin reuptake inhibitor. SGTC_218 alverine citrate 93.75 µM 0.834349145568198 0.178533942524258 no 602 0.202042132653836 959 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1501 4491-0275 38.4 µM 0.832667831598772 0.178999834616477 no 603 0.202516045825099 1017 5104718 SGTC_1070 indatraline 8.81 µM 0.830468196769109 0.17961050737264 no 604 0.203137060903544 975 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1954 st077032 68.9 µM 0.826780701614104 0.180637179926139 no 605 0.204180685098472 937 698907 SGTC_366 0181-0206 4.31 µM 0.826336041703232 0.180761230317523 no 606 0.204306746844916 1018 274874 SGTC_1748 st037455 53.6035 µM 0.82623632187654 0.180789057298349 no 607 0.204335023924286 982 580690 SGTC_406 estrone 100 µM 0.825347860950343 0.181037102308308 no 608 0.204587063428146 1020 5870 A steroid. SGTC_1882 5615643 20 µM 0.825276517045946 0.181057029704402 no 609 0.204607310360025 981 2253075 SGTC_1690 st023502 41.2 µM 0.823875322625697 0.181448682310276 no 610 0.205005201729104 989 24207482 SGTC_1859 st055998 20 µM 0.82247518569906 0.181840568660325 no 611 0.205403251880744 1037 676301 SGTC_3087 9117406 49.47 µM 0.817526545464779 0.183229888492612 no 612 0.206813792799917 1007 42546093 SGTC_127 0180-0333 59.125 µM 0.816688358248537 0.18346586162301 no 613 0.207053272977373 1045 771601 SGTC_116 0155-0182 31.788 µM 0.816121281170648 0.183625617056523 no 614 0.207215386732642 1044 771486 SGTC_2588 indole-3-carbinol 100 µM 0.814057721618432 0.184207688845904 no 615 0.207805942261475 1027 3712 Induces cell cycle arrest. SGTC_1460 k062-0059 9.15 µM 0.813490851298087 0.184367787767117 no 616 0.207968344747115 1026 1373085 SGTC_2810 7959871 45.46 µM 0.813348602220627 0.184407976189521 no 617 0.208009109394829 1046 2974535 SGTC_2341 7987486 176.74 µM 0.812573497197304 0.184627055760596 no 618 0.208231315901177 1062 1258686 SGTC_2616 abietic acid 100 µM 0.812528827865149 0.18463968625485 no 619 0.208244125937553 1053 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1319 1306-0155 43.7 µM 0.811967326754549 0.184798499538545 no 620 0.208405189928428 1049 3122360 SGTC_2228 7354201 200 µM 0.811803910186955 0.184844735735337 no 621 0.208452079012897 1060 753451 SGTC_2970 9090938 41.86 µM 0.809185458964983 0.185586566409776 no 622 0.209204238839865 1069 17217104 SGTC_2584 androsterone 48.74 µM 0.808654591050947 0.185737190982825 no 623 0.209356927187455 1144 2754130 A steroid. SGTC_1995 st072814 61.1 µM 0.808291599764301 0.185840227113802 no 624 0.209461368563807 982 5769371 SGTC_1103 duloxetine 36.1 µM 0.808057704284738 0.185906637801644 no 625 0.209528682189553 1113 60835 A selective serotonin reuptake inhibitor. SGTC_187 1488-2104 32.728 µM 0.806843145964303 0.18625172778315 no 626 0.209878428868606 1080 2852859 SGTC_1118 chelidonine 707.474 nM 0.806622772641425 0.18631438452449 no 627 0.209941924776592 1103 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_103 0844-0104 51.839 µM 0.805944148893365 0.186507413454255 no 628 0.210137526740491 1110 5375804 SGTC_185 k048-0037 25.491 µM 0.803510428873341 0.187200683047185 no 629 0.210839885701122 1073 6827589 SGTC_492 tmb-8 126 µM 0.803128313154168 0.187309677113823 no 630 0.210950287226571 906 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1619 st003326 88.7 µM 0.79970036548698 0.188289213220463 no 631 0.211942210573767 1029 2849032 SGTC_1770 st043884 66.3 µM 0.797599139274613 0.18889119800974 no 632 0.212551575341766 1077 670149 SGTC_478 N-arachidonylglycine 10 µM 0.796906546627128 0.189089879927198 no 633 0.212752654253722 956 5283389 SGTC_1081 sertraline 6 µM 0.795561018109874 0.189476235283754 no 634 0.213143615908508 1058 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3296 9122258 64.045 µM 0.795108310697527 0.189606334930393 no 635 0.213275250373601 1033 4730474 SGTC_1725 st036284 20.55 µM 0.794882646103956 0.189671207235339 no 636 0.213340884931753 1090 707914 SGTC_1988 st071872 53.4 µM 0.794573980099254 0.18975996224686 no 637 0.21343067952107 1060 16414116 SGTC_2183 6420625 130.508 µM 0.793988585604243 0.18992835897499 no 638 0.213601038193754 1106 2897619 SGTC_192 3455-0609 60.9 µM 0.792285277401985 0.190418861179286 no 639 0.214097177112815 1051 3769639 SGTC_310 1273-0058 1.06 µM 0.791759452750017 0.190570440077166 no 640 0.214250474469811 1121 2734232 SGTC_435 c-PAF 6.7 µM 0.791438391572717 0.190663028444207 no 641 0.214344107080431 1043 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1901 st060216 58.6 µM 0.790640812963733 0.190893155476007 no 642 0.214576811725041 1079 688792 SGTC_1323 1348-1351 11.2 µM 0.78921755112174 0.191304235327192 no 643 0.214992432799695 1000 6989654 SGTC_1180 1193-0155 285 µM 0.789069355720525 0.191347069682193 no 644 0.215035735693004 1038 2921347 SGTC_3287 9117173 37.0625 µM 0.788961665669196 0.191378200070189 no 645 0.215067206046208 1038 2789709 SGTC_63 0099-0242 26.702 µM 0.787279322114352 0.191864924651241 no 646 0.215559185787357 1090 3898502 YLR359W ADE13 SGTC_803 4488-1585 147 µM 0.785133101715146 0.192486953928372 no 647 0.216187766794848 1026 747204 SGTC_2567 aureobasidin a 60 nM 0.781262892707946 0.193611750593622 no 648 0.217323945009068 1045 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1383 3049-0032 20.7 µM 0.78119078406018 0.193632745454564 no 649 0.21734514663256 1095 712864 SGTC_1602 st001878 87.6 µM 0.780132854863501 0.19394092739994 no 650 0.217656339757114 1042 595405 YLR310C CDC25 SGTC_1178 0988-0033 191 µM 0.779314154650132 0.194179625361606 no 651 0.217897339305824 1075 5392207 SGTC_1797 st048695 56.8 µM 0.778138459525798 0.194522720595208 no 652 0.218243695933577 1063 592262 YIL048W NEO1 SGTC_414 piperonyl butoxide 100 µM 0.777651756961231 0.194664859660055 no 653 0.218387169993146 1064 5794 A potent inhibitor of cytochrome P450. SGTC_2461 5755302 26.15 µM 0.775994740086055 0.195149256817895 no 654 0.218876045780322 1063 2788904 SGTC_1262 0737-0114 49.6 µM 0.774653876235849 0.19554176844895 no 655 0.219272106247731 1126 765919 SGTC_756 0508-1999 28.3 µM 0.774602060505379 0.195556946103984 no 656 0.219287419689692 1057 6753853 SGTC_380 3970-0968 6 µM 0.773499266063659 0.195880141813889 no 657 0.219613481469101 1035 2891601 SGTC_2418 pentamidine 31.67 µM 0.770052525744869 0.196892364869693 no 658 0.220634367797264 1105 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2634 4'-methoxyflavone 100 µM 0.769009893977523 0.197199183013152 no 659 0.220943718516842 1046 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2934 9036370 36.88 µM 0.768469658461937 0.197358273327107 no 660 0.221104104968277 1102 6462800 SGTC_2499 avocadenofuran 51.48 µM 0.768416903616012 0.197373812905029 no 661 0.22111977052656 1058 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1226 3909-7979 35.4 µM 0.768163686470156 0.197448411377554 no 662 0.221194972229908 1100 6615510 SGTC_1884 5633444 25 µM 0.767855507244623 0.197539224828925 no 663 0.221286516584966 1077 5724239 SGTC_1491 4138-0063 26.5 µM 0.766783244885869 0.19785539302978 no 664 0.221605199937328 1068 23883227 SGTC_2294 7971431 200 µM 0.766544109355806 0.197925946408528 no 665 0.221676308327247 1007 5741572 SGTC_1833 st055984 71 µM 0.766013596091005 0.198082520694598 no 666 0.221834106177324 1067 676288 SGTC_945 3381-0768 11.3 µM 0.765314925312301 0.198288838616969 no 667 0.222042019280793 1120 1126236 YIL048W NEO1 SGTC_230 MPP+ 141.667 µM 0.765314462259369 0.198288975399787 no 668 0.222042157114722 1062 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_559 1550-0661 158 µM 0.764997874552664 0.19838250667381 no 669 0.222136405133165 1092 5830875 SGTC_2691 st077356 60.2 µM 0.764818578252403 0.198435488986859 no 670 0.222189791687078 1107 2839272 SGTC_2019 4016004 108 µM 0.764712145148943 0.198466944158912 no 671 0.22222148624807 1075 45595336 SGTC_1200 1643-0193 18.4 µM 0.763459153218398 0.198837478721999 no 672 0.222594806828209 1122 5403974 SGTC_2075 5212009 200 µM 0.763236724921228 0.198903298737982 no 673 0.222661115203784 1008 780898 SGTC_819 1013-0258 27.7 µM 0.763035337702907 0.198962903695295 no 674 0.222721160708042 1109 5753198 SGTC_255 tunicamycin 200.472 nM 0.762711564951785 0.199058753892279 no 675 0.222817715959443 1082 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2333 9017922 200 µM 0.756346887473541 0.200948606857089 no 676 0.224720621575212 1113 3163164 SGTC_3329 9141233 27.5565 µM 0.755338912071572 0.201248887606277 no 677 0.225022828284055 1098 4909101 YNL103W MET4 SGTC_3216 9129716 49.47 µM 0.754650155180866 0.201454226249222 no 678 0.225229460700853 1068 8056934 SGTC_1607 st000305 50.6 µM 0.754300218613267 0.201558600692497 no 679 0.225334485548183 1090 5457690 SGTC_501 nsc-95397 161 µM 0.753731522343314 0.201728292976055 no 680 0.225505224875182 1080 262093 SGTC_1044 1222-0021 1.78 µM 0.752983365597111 0.201951664430929 no 681 0.225729955002303 1048 4306703 SGTC_2779 methotrexate 400 µM 0.752569818564086 0.202075197526753 no 682 0.225854229948199 1197 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2403 6032726 181.2 µM 0.751762810025157 0.202316394035176 no 683 0.2260968553317 1098 2881040 SGTC_1060 3448-7350 82 µM 0.75056738835033 0.20267399467621 no 684 0.226456526864412 1067 570178 SGTC_2518 prenyletin 46.28 µM 0.750285972713125 0.202758232763843 no 685 0.226541244524061 1034 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2803 7707263 71.43 µM 0.750111623825967 0.202810432314794 no 686 0.226593739671631 1075 2199229 SGTC_292 k038-0015 474 µM 0.74951868148439 0.20298801760415 no 687 0.226772321557668 1127 46368540 SGTC_2434 5670830 169.91 µM 0.747423558063039 0.203616247084718 no 688 0.227403964721657 1085 1549830 SGTC_2215 7188065 200 µM 0.747220961576644 0.203677057710287 no 689 0.2274650965367 1121 940217 SGTC_1091 telmisartan 47.6 µM 0.74717726553001 0.203690174776439 no 690 0.227478282670939 1176 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1753 st043925 64 µM 0.746854318056452 0.203787135624762 no 691 0.227575751717625 1127 670181 SGTC_1079 idarubicin 2.36 µM 0.746355953055093 0.203936817319452 no 692 0.227726209810238 1085 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2732 terfenadine 20 µM 0.74415933321993 0.204597342593243 no 693 0.228390043678211 1117 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_368 fentichlor 4.58 µM 0.741276804446305 0.205466049684783 no 694 0.229262811425733 1084 7329 A pesticide. SGTC_464 bw-b 70c 158 µM 0.738962817872945 0.206164997596887 no 695 0.229964787838808 1153 5353454 SGTC_3091 9116372 49.47 µM 0.738326786529026 0.206357359828706 no 696 0.230157946365242 1118 17169793 SGTC_788 1182-0090 188 µM 0.737356540343971 0.206651007268647 no 697 0.230452778490399 1191 5715185 SGTC_3108 9121785 49.47 µM 0.735891396406483 0.20709490542646 no 698 0.230898396791277 1115 17140271 SGTC_604 1000-0114 314 µM 0.734292276800285 0.207580037756831 no 699 0.231385311963888 1168 1572745 SGTC_1387 3342-1166 1.8 µM 0.733452958142105 0.207834934261108 no 700 0.231641104672734 1090 3418228 SGTC_996 3970-0799 1.8 µM 0.733432516988934 0.207841144432861 no 701 0.231647336331322 1266 6615648 YGL040C HEM2 SGTC_2445 5742597 35.57 µM 0.731370315871879 0.208468219230294 no 702 0.232276495743465 1089 1774255 SGTC_3128 9127691 49.47 µM 0.730423887052727 0.208756382734131 no 703 0.232565560844688 1042 41316314 SGTC_587 k089-0003 57 µM 0.730380288874285 0.208769662923926 no 704 0.232578881731393 1088 9659696 SGTC_1492 4158-0558 28.5 µM 0.729457935877949 0.209050732211793 no 705 0.232860794729103 1135 3967268 SGTC_994 3910-0338 138 µM 0.72557590042516 0.210236147964767 no 706 0.234049399734884 1193 3479481 SGTC_1181 1222-0449 220 µM 0.724875982087718 0.210450293819994 no 707 0.234264058320402 1185 658318 SGTC_2141 5621638 7.665 µM 0.723340453799997 0.21092054984173 no 708 0.234735372456165 1152 2856238 SGTC_183 3914-0051 30.55 µM 0.722216276484939 0.211265219815372 no 709 0.235080758904661 1150 1596232 SGTC_2045 5106652 78.05 µM 0.721865452406454 0.211372849125825 no 710 0.235188601731091 1147 673349 SGTC_3024 9090631 49.47 µM 0.720786449671823 0.211704077570523 no 711 0.235520456814999 1124 25236383 SGTC_2117 5521686 200 µM 0.720610582484744 0.211758093434679 no 712 0.235574570514641 1158 803312 SGTC_1800 st050079 29.0735 µM 0.719762703370534 0.212018624250942 no 713 0.23583555608601 1171 3645560 SGTC_965 1291-5240 308 µM 0.718811641045003 0.212311083485957 no 714 0.23612849204871 1141 2834598 SGTC_270 tamoxifen 5.46 µM 0.715977992321377 0.213183849499692 no 715 0.23700246908824 1245 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3233 9132340 49.47 µM 0.715834924612882 0.213227969884283 no 716 0.237046642295819 1139 17682950 SGTC_8 0354-0001 70 µM 0.714345963483986 0.213687463828816 no 717 0.237506638472049 1205 4993152 SGTC_2791 5663188 71.43 µM 0.711035292151369 0.214711202790462 no 718 0.23853118311687 1141 54690634 SGTC_1002 4049-0206 172 µM 0.710860247916117 0.214765409877167 no 719 0.238585420848141 1208 4662749 SGTC_2566 crystal violet carbinol 226 nM 0.709796382910268 0.215095034852153 no 720 0.238915206226161 1132 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1583 clindamycin 39.6 µM 0.709001045619631 0.215341651702127 no 721 0.239161913985466 1102 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2551 apiole 73.87 µM 0.707057495258419 0.215944994388205 no 722 0.23976537432865 1067 10659 A possible DNA adduct former. SGTC_2711 st079103 59.1 µM 0.706860279801334 0.216006271313326 no 723 0.239826654900279 1174 54693780 SGTC_1267 0828-0272 9.49 µM 0.70648770890963 0.216122060509339 no 724 0.239942446813625 1196 745334 SGTC_1394 3474-0001 65.7 µM 0.702794884336047 0.217271674869968 no 725 0.241091792870672 1118 5017666 YIL048W NEO1 SGTC_450 aminopyrene 156 nM 0.702663629766236 0.217312600662132 no 726 0.241132699248194 1162 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2114 5491910 81.25 µM 0.702660967161556 0.217313430920862 no 727 0.24113352910606 1204 2849228 SGTC_2466 5983409 37.09 µM 0.70211573881614 0.217483483706653 no 728 0.241303493922012 1143 2879657 SGTC_2841 9004761 38.96 µM 0.700770705810405 0.217903318124541 no 729 0.241723061230668 1112 2991039 SGTC_2858 9025781 8.96 µM 0.700026698217305 0.218135750961871 no 730 0.241955315677607 1215 4894980 YPL153C RAD53 SGTC_1205 4161-2785 76 µM 0.69709909988868 0.219051738043051 no 731 0.242870388733692 1154 3498106 SGTC_150 3970-0969 77.2 µM 0.696524283982134 0.219231845901398 no 732 0.243050277378538 1203 6615640 SGTC_1997 st073024 93.8 µM 0.695226339508534 0.21963884558972 no 733 0.243456734045825 1183 686268 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.695024877142841 0.219702057524384 no 734 0.243519855723381 1166 756377 SGTC_1596 piperlongumine 63 µM 0.692780967339196 0.220406824678871 no 735 0.244223509046873 1213 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1291 0993-0025 5.79 µM 0.692106468719535 0.220618924220438 no 736 0.244435234824325 1210 4353356 SGTC_254 nsc-64875 3.808 µM 0.691808972990819 0.220712510421196 no 737 0.244528650446178 1217 56993 SGTC_3312 9133330 71.43 µM 0.691401422126592 0.220840754667794 no 738 0.244656655319193 1222 17617324 SGTC_2745 rifampicin 24.3 µM 0.690936769114579 0.220987019315216 no 739 0.244802639026112 1118 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_340 k038-0059 454 µM 0.690345297292133 0.221173284494238 no 740 0.244988534209673 1190 23733424 SGTC_2643 anethole 100 µM 0.690295644857355 0.221188925029856 no 741 0.245004143054325 1202 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3142 9086498 49.47 µM 0.690147864445977 0.221235479658963 no 742 0.245050602783406 1136 25236367 SGTC_2389 9091542 195.52 µM 0.68938203014245 0.221476826921447 no 743 0.245291444380792 1189 3626624 YOL127W RPL25 SGTC_3086 9117350 49.47 µM 0.689254079053655 0.221517164471135 no 744 0.24533169517954 1139 2679265 SGTC_572 0960-0087 17.7 µM 0.689079202018686 0.221572302572334 no 745 0.245386713663817 1204 6796365 SGTC_2321 7390090 138.78 µM 0.687424312418544 0.222094471513874 no 746 0.245907690585617 1158 649046 SGTC_378 3970-0959 8.33 µM 0.686640841441611 0.222341925667245 no 747 0.246154542492781 1203 6615653 SGTC_1506 4226-2149 212 µM 0.685859442369612 0.222588882007726 no 748 0.246400873901625 1227 991114 SGTC_2807 7945238 51.95 µM 0.685693103185643 0.222641472658014 no 749 0.24645332838964 1230 17148797 SGTC_2938 9059746 27.26 µM 0.685543728066424 0.222688705898292 no 750 0.246500438417363 1161 6471769 SGTC_1507 4075-3230 155 µM 0.684590012896564 0.222990410531009 no 751 0.246801335473766 1146 659771 SGTC_759 3486-0358 89.3 µM 0.683310883561764 0.223395424136674 no 752 0.247205209188166 1241 875103 SGTC_2800 7887935 81.82 µM 0.683169519848747 0.223440210118121 no 753 0.247249865201429 1194 2961002 SGTC_404 fumagillin 50 µM 0.682736693812863 0.223577367157506 no 754 0.247386619362909 1198 12015870 A methionine aminopeptidase binder. SGTC_663 1486-0733 13.9 µM 0.682539142373331 0.223639984595517 no 755 0.247449050441522 1216 722445 YPR165W RHO1 SGTC_1130 3454-2858 15.9 µM 0.681724451954991 0.223898320533054 no 756 0.247706601437708 1188 715628 YIL048W NEO1 SGTC_2254 7938975 95.19 µM 0.681226455307937 0.224056317282933 no 757 0.247864105367417 1260 2969277 SGTC_1247 0448-0043 5.84 µM 0.681146410864152 0.224081718464994 no 758 0.247889426416162 1250 3089013 YGL099W LSG1 SGTC_76 0433-0009 400.328 µM 0.680357230252884 0.224332243388469 no 759 0.248139147626895 1201 2841569 SGTC_173 1273-0061 2.693 µM 0.680051038501355 0.224429486575992 no 760 0.248236072306424 1183 2847414 YPL266W DIM1 SGTC_2138 5575593 77.673 µM 0.679940910296438 0.224464467951083 no 761 0.248270938210472 1214 762213 SGTC_2880 9042983 58.44 µM 0.679792132266724 0.224511731058221 no 762 0.248318044554498 1226 6464714 SGTC_50 0929-0078 56.389 µM 0.679608365428736 0.224570117040052 no 763 0.248376235689355 1131 1377751 SGTC_1998 st075797 76.8 µM 0.679541405992016 0.224591393381042 no 764 0.248397440699217 1224 24208315 SGTC_313 3474-0040 5.03 µM 0.67879176897121 0.224829668372267 no 765 0.248634904915663 1203 1043375 YIL048W NEO1 SGTC_1948 st076329 66.6 µM 0.676311540613698 0.225619039171429 no 766 0.249421433543019 1138 24208413 SGTC_3214 9129694 49.47 µM 0.674533361913638 0.226185935754012 no 767 0.249986141421701 1194 17158655 SGTC_1228 0124-0032 52.5 µM 0.674168811219759 0.226302256562349 no 768 0.250101997925536 1268 X1228 SGTC_1922 5578187 25 µM 0.673459467862525 0.226528690606034 no 769 0.25032751331468 1263 1350412 SGTC_3195 9113082 49.47 µM 0.672395125747773 0.226868685911151 no 770 0.250666092509202 1202 17018038 SGTC_1482 3346-2049 8.48 µM 0.672387769710319 0.226871036737771 no 771 0.250668433391095 1223 3826804 SGTC_1603 st002045 67.8 µM 0.669644741449604 0.227748605148722 no 772 0.251542142663942 1235 5887985 SGTC_565 1418-0001 44.5 µM 0.668175453142192 0.228219454612768 no 773 0.252010801219079 1271 2862145 SGTC_2830 7992007 71.43 µM 0.667043615580972 0.228582537140986 no 774 0.252372137099822 1184 1952075 SGTC_2619 obliquin 87.91 µM 0.666863648486135 0.228640298722019 no 775 0.252429616229519 1221 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2101 5377231 179.231 µM 0.66662729801206 0.228716169355993 no 776 0.252505113950152 1241 2844213 SGTC_1919 st067113 52.3 µM 0.666382224935373 0.228794854949828 no 777 0.252583410505195 1239 1268243 SGTC_1274 0865-0114 173 µM 0.666111330693179 0.228881848622598 no 778 0.252669971350027 1256 870624 SGTC_2605 digitonin 300 nM 0.665104070260676 0.229205478178494 no 779 0.252991965738797 1290 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2024 5144227 134 µM 0.664804122772651 0.229301899908808 no 780 0.253087892683481 1239 3475211 SGTC_2960 9079389 5.97 µM 0.662572221624629 0.230020085132607 no 781 0.253802282939233 1232 16457355 SGTC_1862 st057513 3.81 µM 0.662298215000107 0.230108342157933 no 782 0.253890060293121 1224 5393163 SGTC_1655 st012546 55.1 µM 0.662223460777245 0.230132423643541 no 783 0.253914010392225 1220 720985 YLR208W SEC13 SGTC_724 3910-0327 137 µM 0.662212309696166 0.230136015997548 no 784 0.2539175831281 1245 2885483 SGTC_2339 9000433 200 µM 0.660962249855758 0.230538925328494 no 785 0.254318261590909 1215 2988954 SGTC_786 4544-0069 423 µM 0.660126091332793 0.230808649174285 no 786 0.254586458210203 1268 748821 YLR208W SEC13 SGTC_3039 9090270 49.47 µM 0.659067746575983 0.23115029731694 no 787 0.254926133050899 1250 17173750 SGTC_542 3381-0244 89.3 µM 0.658943467277662 0.231190434877817 no 788 0.254966035939209 1264 1112843 SGTC_3218 9131285 49.47 µM 0.658513527875311 0.23132931920128 no 789 0.25510410363577 1275 17156417 SGTC_551 k048-0028 34.9 µM 0.657136349102659 0.231774505571484 no 790 0.255546624190641 1256 6836383 SGTC_2809 7964133 12.99 µM 0.657056324872638 0.231800388843595 no 791 0.255572350215827 1262 1253665 SGTC_3090 9117696 49.47 µM 0.655961092977257 0.232154795649582 no 792 0.255924579025655 1228 7923821 SGTC_3265 9137266 49.47 µM 0.655378273319423 0.232343513519264 no 793 0.256112118226693 1213 17224265 SGTC_3183 9108214 49.47 µM 0.653964415640581 0.232801677167325 no 794 0.256567365771031 1182 4974831 SGTC_3322 9139058 2.11 µM 0.653704681228767 0.232885899215134 no 795 0.256651043367141 1305 4908926 YPR165W RHO1 SGTC_3297 9117502 71.43 µM 0.65364651863021 0.232904761465732 no 796 0.256669783326037 1248 7453720 SGTC_3168 9103419 49.47 µM 0.652275372889519 0.233349672594557 no 797 0.257111772063059 1211 16649256 SGTC_568 1193-0097 7.48 µM 0.651585876200208 0.23357357943429 no 798 0.257334180741068 1177 3646150 SGTC_843 0310-0051 143 µM 0.650668826439696 0.233871566275116 no 799 0.257630145316047 1265 2065037 SGTC_2507 purpurin 79.67 µM 0.650145422782105 0.234041735834949 no 800 0.257799145486673 1251 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_791 1348-1292 225 µM 0.649730531207512 0.234176674541622 no 801 0.257933149398966 1271 5437054 SGTC_257 daunorubicin 18.5 µM 0.647710057780072 0.234834425547501 no 802 0.258586248898746 1308 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2408 sulbentine 18.36 µM 0.646732715682141 0.23515295851386 no 803 0.258902472772538 1282 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_899 1083-0020 478 µM 0.646661966913886 0.235176026039026 no 804 0.258925371649482 1324 767123 SGTC_2490 carminic acid 95.39 µM 0.646459453398881 0.23524206216106 no 805 0.258990923911305 1224 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1588 farnesol 29.9 µM 0.646013965094753 0.235387364146664 no 806 0.259135155680355 1297 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2563 tomatine 8.54 µM 0.644732808325926 0.235805506551572 no 807 0.259550175674278 1289 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2471 5466956 24.79 µM 0.643056621099337 0.236353196376326 no 808 0.260093680280495 1255 724419 SGTC_1967 st070177 51.4 µM 0.642970098219935 0.236381486498452 no 809 0.260121751287289 1339 5729214 SGTC_3166 9102297 49.47 µM 0.642323201576457 0.236593059381014 no 810 0.260331676352069 1234 25237072 SGTC_1276 0871-0068 94.2 µM 0.641681284087661 0.236803106739766 no 811 0.260540071867397 1252 3414906 SGTC_1113 artemisinin 1.17947 µM 0.641599112877147 0.236830002091962 no 812 0.260566754566938 1290 2240 An anti-malaria and mitochondrial poison. SGTC_51 1013-0126 23.419 µM 0.640521504397572 0.237182868127834 no 813 0.260916806587162 1385 1627850 SGTC_3275 9138069 49.47 µM 0.640441960535902 0.23720892643883 no 814 0.260942655321306 1302 17617007 SGTC_876 0720-0963 56.8 µM 0.640410370012795 0.237219275827993 no 815 0.260952921406924 1310 765861 SGTC_45 0kpi-0036 14.9 µM 0.639272514210846 0.237592214724943 no 816 0.261322832909296 1286 2795021 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.639258242094885 0.237596894536691 no 817 0.2613274744161 1295 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.638905154498019 0.237712687690651 no 818 0.261442317295845 1306 5377381 SGTC_1989 st071868 50.2 µM 0.638224630131754 0.23793594925625 no 819 0.261663733126978 1277 16414057 SGTC_768 0384-0033 77.3 µM 0.636800514791972 0.238403534629067 no 820 0.262127395369862 1263 3965305 YMR134W ERG29 SGTC_3072 9116419 49.47 µM 0.635908778449806 0.238696577904038 no 821 0.262417940331413 1246 17170162 SGTC_1338 1486-1223 76 µM 0.634540373769636 0.239146647420884 no 822 0.262864113506892 1323 3444526 SGTC_348 k064-0012 10.7 µM 0.631443469661736 0.240166932259369 no 823 0.263875300395777 1229 5066323 SGTC_2163 5671233 125 µM 0.631192138956441 0.240249837909867 no 824 0.263957450655258 1371 701023 SGTC_2519 cryptotanshinone 88.04 µM 0.630657099284649 0.24042638164879 no 825 0.264132377773351 1276 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2493 resveratrol 26.09 µM 0.630311622629893 0.240540413980311 no 826 0.264245360084795 1225 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2650 prasterone 100 µM 0.629463909421547 0.240820345510948 no 827 0.264522694632455 1264 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_855 0428-0020 25 µM 0.629381490922513 0.240847571167152 no 828 0.264549666244669 1286 6812414 SGTC_312 4092-0653 6.84 µM 0.627516980663522 0.241463930052512 no 829 0.265160204442711 1321 1148278 SGTC_1086 cerivastatin 2.18 µM 0.627406216972716 0.241500572605076 no 830 0.265196496773931 1281 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_506 n9-isopropylolomoucine 153 µM 0.627029282422654 0.241625291722514 no 831 0.265320020342385 1323 6610355 SGTC_3038 9091290 49.47 µM 0.625743282564383 0.242051063036491 no 832 0.265741669392006 1327 25236843 SGTC_2555 cholic acid 100 µM 0.624692206667726 0.242399357211635 no 833 0.266086544521042 1304 6708657 Influences liver metabolism. SGTC_986 1493-0483 84 µM 0.62444838914826 0.24248018960844 no 834 0.26616657739792 1265 40079 SGTC_790 1575-0012 79.1 µM 0.624222224272532 0.242555182706538 no 835 0.266240826705328 1325 378741 YLR208W SEC13 SGTC_2056 5235370 200 µM 0.623546805414611 0.242779216867477 no 836 0.266462627252069 1299 5511916 SGTC_2909 7941780 10.49 µM 0.62280554913593 0.243025217926883 no 837 0.2667061556597 1308 1243215 SGTC_3048 9093155 49.47 µM 0.622762504618831 0.243039507271106 no 838 0.266720300732568 1263 25236002 SGTC_459 nigericin 15.3 µM 0.622410449632033 0.243156394841713 no 839 0.266836005504664 1354 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_224 benfluorex 43.875 µM 0.622004474345709 0.243291222491645 no 840 0.266969462952781 1315 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_732 3970-1727 52.7 µM 0.62106907426919 0.243602030109656 no 841 0.2672770880395 1328 1275699 SGTC_1786 berberine 21.6 µM 0.620870833496051 0.243667927571551 no 842 0.267342306459336 1273 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_769 0302-0231 76 µM 0.620199606703037 0.24389112235419 no 843 0.267563190209992 1314 571869 YER009W NTF2 SGTC_973 1325-0077 65.9 µM 0.619626745080425 0.244081696197129 no 844 0.267751777217143 1347 2835149 SGTC_3237 9133362 49.47 µM 0.619309002594688 0.24418743418884 no 845 0.267856407445748 1306 43845137 SGTC_446 go6976 132 µM 0.619115933188201 0.244251695672619 no 846 0.267919993817643 1285 3501 A protein kinase C inhibitor. SGTC_1184 1269-1718 139 µM 0.619098713473435 0.244257427548679 no 847 0.267925665407422 1364 5403821 SGTC_811 0416-0114 265 µM 0.617890889370934 0.244659653281646 no 848 0.268323632482907 1321 6612453 SGTC_1642 st009582 77.7 µM 0.617354174328585 0.244838502808826 no 849 0.268500570585706 1340 6739311 SGTC_1509 1326-1131 80 µM 0.615556388406138 0.245438091195929 no 850 0.269093671149846 1285 768313 SGTC_199 4063-0024 41.6 µM 0.615291799094659 0.245526402231818 no 851 0.269181016247611 1342 306215 SGTC_1562 morin hydrate 59.1 µM 0.614556606613309 0.245771874405264 no 852 0.269423789504735 1346 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3302 9125395 16.351 µM 0.612998553594834 0.246292525272641 no 853 0.269938648053588 1330 17599668 SGTC_2203 7227154 166.4 µM 0.612939800986207 0.246312170054305 no 854 0.269958072480918 1302 896304 SGTC_2456 5770359 74.46 µM 0.611692634324776 0.24672937629645 no 855 0.270370568039126 1365 3118787 SGTC_1472 k841-0093 193 µM 0.61154425301695 0.24677903846865 no 856 0.27041966554667 1373 X1472 SGTC_1210 3013-0140 750 nM 0.608116843849834 0.247927656056203 no 857 0.271554990759882 1374 905973 SGTC_68 0986-0284 82.829 µM 0.607586992280641 0.248105477949381 no 858 0.271730715077791 1284 423278 YIL048W NEO1 SGTC_343 4130-2827 29.8 µM 0.607265907441865 0.248213269363828 no 859 0.271837229820158 1325 1118244 SGTC_643 k048-0106 28.4 µM 0.604931700991434 0.2489976360965 no 860 0.272612189270119 1369 6763920 SGTC_285 1486-1325 46 µM 0.603937942256075 0.249331970110999 no 861 0.272942450903944 1368 22310230 SGTC_898 1000-0849 28.3 µM 0.602318554911215 0.249877297631821 no 862 0.273481056047217 1323 6751807 SGTC_2060 5238662 140 µM 0.601291857336523 0.250223364958685 no 863 0.273822806013788 1318 790130 SGTC_1550 gossypolone 36.6 µM 0.601050158442929 0.250304870966566 no 864 0.273903289408396 1327 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2514 salinomycin 42.74 µM 0.599228916478353 0.250919484857977 no 865 0.274510121171653 1399 23682228 A polyether potassium ionophore. SGTC_3314 9135860 59.4275 µM 0.599178214360832 0.250936606704475 no 866 0.274527024434746 1336 25252478 SGTC_521 r062-0005 13.8 µM 0.598411774850557 0.25119550472123 no 867 0.274782605465895 1318 2832033 SGTC_484 loperamide 105 µM 0.598347661794012 0.251217168073472 no 868 0.274803990265193 1324 3955 An opioid-receptor agonist. SGTC_2380 9035439 200 µM 0.597782718841775 0.251408101037298 no 869 0.274992461468737 1400 6462575 SGTC_1056 3448-1962 115 µM 0.596515418488356 0.251836687582647 no 870 0.275415478368158 1364 715507 SGTC_2025 5147754 141 µM 0.595938657013914 0.252031869381693 no 871 0.275608103679403 1354 315777 YLR208W SEC13 SGTC_2694 st077685 81.9 µM 0.595834061508834 0.252067274084881 no 872 0.275643043311258 1301 2838096 SGTC_2624 nerol 100 µM 0.595826155871121 0.252069950183742 no 873 0.275645684240517 1332 637566 A natural product oil. SGTC_454 lyso-paf C-16 6.67 µM 0.595137098896905 0.252303257074077 no 874 0.27587591594866 1267 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2924 9010168 62.78 µM 0.595137005989649 0.252303288539096 no 875 0.275875946997739 1358 2993929 SGTC_888 0916-0002 6.97 µM 0.595127569696888 0.252306484351232 no 876 0.275879100562344 1393 2802138 YIL048W NEO1 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.594743993023661 0.252436409256085 no 877 0.276007305069601 1362 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2855 9016525 58.44 µM 0.594177971417716 0.252628196206171 no 878 0.27619654236883 1314 43811474 SGTC_866 0495-0101 262 µM 0.594177737431701 0.252628275504285 no 879 0.276196620610249 1295 635694 SGTC_1935 st074532 41.6 µM 0.593666861561781 0.252801443148224 no 880 0.276367475783146 1401 2829742 SGTC_1921 5740136 50 µM 0.591567558951385 0.253513683018215 no 881 0.277070101433537 1413 1774243 SGTC_2740 felodipine 17.08 µM 0.590001440673286 0.254045712889563 no 882 0.277594841820968 1377 3333 L-type calcium channel blocker SGTC_1138 3761-0006 1.03 µM 0.589808129742552 0.254111423608073 no 883 0.277659645836572 1342 12061087 SGTC_571 k831-0106 44.2 µM 0.589361883543689 0.254263146730806 no 884 0.277809270069383 1404 4783639 SGTC_2355 9061122 103.12 µM 0.586058151112979 0.255387887179832 no 885 0.278918218831923 1365 5302957 SGTC_514 4466-0038 2.65 nM 0.582350401319846 0.256653263169272 no 886 0.280165341383699 1322 5722064 SGTC_2365 9042475 200 µM 0.580848913498783 0.257166616129225 no 887 0.280671142782672 1366 6464479 SGTC_2781 5567276 71.43 µM 0.580803438488944 0.257182172187101 no 888 0.28068646869304 1401 2853274 SGTC_2697 mebhydrolin 72.4 µM 0.580445645115259 0.257304582946542 no 889 0.280807065726436 1428 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_653 0203-0016 55.2 µM 0.580295649047829 0.257355909652292 no 890 0.28085763051717 1403 295302 SGTC_2895 9054447 58.44 µM 0.579686277214365 0.257564483479873 no 891 0.281063099552565 1378 2697450 SGTC_2133 5320837 200 µM 0.577914949178687 0.258171266047357 no 892 0.281660770980789 1412 2841355 SGTC_1327 1436-0082 2.18 µM 0.577388601697273 0.258351713303372 no 893 0.281838486182393 1345 15992205 SGTC_2288 7946289 167.31 µM 0.575847735047176 0.258880342748222 no 894 0.282359052578265 1469 1246052 SGTC_2047 4141938 200 µM 0.575574971503106 0.25897397876875 no 895 0.282451251179965 1388 3807862 SGTC_3025 9087895 49.47 µM 0.574776500734346 0.259248183602079 no 896 0.282721230737853 1386 17173641 SGTC_1313 1220-0047 237 µM 0.573648474726638 0.259635817386216 no 897 0.283102850959152 1427 3528706 SGTC_2358 9037157 4 µM 0.573179940934588 0.259796911796943 no 898 0.283261432317109 1414 2388925 SGTC_161 4065-0411 162.148 µM 0.572589016200472 0.260000160995159 no 899 0.283461499214982 1418 1906281 YLR208W SEC13 SGTC_3266 9136860 49.47 µM 0.571075108833895 0.260521244945809 no 900 0.283974365263067 1322 4871271 YPR165W RHO1 SGTC_1279 0874-0590 65.2 µM 0.570859972039231 0.260595338222005 no 901 0.28404728312141 1402 3523074 SGTC_985 1493-0307 8.71 µM 0.569064776553292 0.261214027562641 no 902 0.284656090558764 1373 3278274 SGTC_2625 euphol 100 µM 0.568782722296502 0.261311302232057 no 903 0.284751800655854 1432 6708538 A triterpene alcohol. SGTC_3188 9110789 49.47 µM 0.568740768986813 0.26132577264898 no 904 0.284766038077578 1416 849217 SGTC_2718 lomofungin 53.02 µM 0.568049137834927 0.261564387423215 no 905 0.285000801392904 1446 5351222 A RNA synthesis inhibitor. SGTC_265 mycophenolic acid 32.932 µM 0.567606691145756 0.26171709146365 no 906 0.285151031350644 1454 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2492 derrusnin 100 µM 0.566519826302465 0.262092401154145 no 907 0.285520229542036 1324 1715307 Part of coumarin class of compounds. SGTC_261 5-fluorouridine 15.376 µM 0.565479090986009 0.262452040020507 no 908 0.285873971077229 1433 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1717 st033143 58.0435 µM 0.564066385938409 0.262940621514339 no 909 0.286354476688361 1474 674616 SGTC_2210 7115885 190.385 µM 0.564033024961107 0.262952164965612 no 910 0.286365828442757 1384 2927039 SGTC_776 4476-4378 112 µM 0.563996566157282 0.262964780612488 no 911 0.286378234540222 1389 2892008 SGTC_22 0964-0034 14.468 µM 0.562533080423532 0.263471438184064 no 912 0.286876435800924 1353 138402 SGTC_854 0422-0053 192 µM 0.561579443885891 0.263801854294333 no 913 0.287201294537456 1374 3596728 SGTC_751 0833-0568 350 µM 0.560875176083502 0.264046004661891 no 914 0.287441316898699 1419 6954252 SGTC_339 3091-4833 71.4 µM 0.560638937560062 0.26412792787176 no 915 0.287521850879248 1389 3240077 SGTC_1724 st037281 8.293 µM 0.560179215348205 0.264287388254815 no 916 0.28767860127654 1389 574124 YDL195W SEC31 SGTC_3207 9114163 49.47 µM 0.559221216018179 0.264619839703247 no 917 0.288005377744668 1545 849233 SGTC_1135 dihydrocapsaicin 536.708 nM 0.557504197302142 0.265216223061029 no 918 0.288591496068752 1334 107982 A Capsaicinoid. SGTC_1416 3966-0321 25.3 µM 0.55663418210068 0.2655186714435 no 919 0.288888697190858 1383 582530 YLR208W SEC13 SGTC_1877 wortmannin 25 µM 0.556592006602795 0.265533337599474 no 920 0.288903108191262 1389 312145 A covalent inhibitor of PI 3-kinase. SGTC_2073 5212005 126 µM 0.556035085068578 0.265727040665149 no 921 0.28909343515122 1304 691789 SGTC_321 4534-3890 65.3 µM 0.555528114488481 0.265903432539654 no 922 0.289266742714861 1432 699746 SGTC_3097 9117246 49.47 µM 0.555065957342606 0.266064284014196 no 923 0.28942477337053 1395 16423892 SGTC_1968 st069590 43.6 µM 0.554964166719775 0.266099718350656 no 924 0.289459585246539 1393 6384066 SGTC_3260 9137109 49.47 µM 0.554805512671255 0.266154952180594 no 925 0.289513848046559 1369 17478346 SGTC_1630 st005209 31.3 µM 0.554551053638904 0.266243551682988 no 926 0.2896008880059 1424 3367314 SGTC_1213 1315-0166 115 µM 0.554494545758524 0.266263229056874 no 927 0.28962021869232 1354 768401 SGTC_191 3914-0123 66.505 µM 0.552963891525311 0.266796518754346 no 928 0.290144067915931 1316 3144412 SGTC_2692 st077426 47.7 µM 0.552084839321148 0.267103029965544 no 929 0.290445114237017 1412 25238571 SGTC_1489 4065-0444 182 µM 0.551545470995409 0.2672911869001 no 930 0.290629902410957 1438 2877968 SGTC_669 0108-0021 26.2 µM 0.551401596373921 0.267341388403716 no 931 0.290679203302909 1649 17201 SGTC_2229 7354935 190 µM 0.549910544274998 0.267861934227403 no 932 0.2911903658342 1406 318112 SGTC_3215 9129942 49.47 µM 0.547954861465635 0.26854546180857 no 933 0.291861448598352 1389 17682944 SGTC_2350 9023895 38.85 µM 0.546302863359015 0.26912353133818 no 934 0.292428884162211 1482 2997209 SGTC_200 k038-0079 37.545 µM 0.54289220639231 0.270318965119721 no 935 0.29360201114667 1440 3436683 SGTC_953 1188-0045 9.7 µM 0.542410729341328 0.27048793619351 no 936 0.293767794978324 1479 6144426 SGTC_807 1315-0151 48 µM 0.5417431399286 0.270722309409398 no 937 0.293997733295119 1489 4011080 SGTC_1705 st027868 56.3335 µM 0.539288867308982 0.271584811111066 no 938 0.294843774636335 1463 292948 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.538969505415 0.27169714455872 no 939 0.294953948119998 1338 6708630 An antioxidant. SGTC_2064 5220758 200 µM 0.536550628513204 0.272548718890494 no 940 0.295789027653449 1459 788518 SGTC_2618 avocadyne 43.43 µM 0.535990326600814 0.272746164052462 no 941 0.295982617981009 1426 3015189 SGTC_56 0957-0365 83.25 µM 0.535973097611146 0.272752236512047 no 942 0.295988571703661 1388 6752360 SGTC_3073 9114972 49.47 µM 0.53545032782554 0.272936521713103 no 943 0.296169248381888 1470 41905075 SGTC_1837 st055472 66.5 µM 0.534751688641669 0.273182900207467 no 944 0.296410786989864 1495 676091 SGTC_1742 st038235 28.8875 µM 0.53402025045518 0.273440963453146 no 945 0.2966637618162 1450 564103 YBR002C RER2 SGTC_2721 ifenprodil 61.44 µM 0.533763276537023 0.273531656656848 no 946 0.296752662145905 1489 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1824 st053723 68.6 µM 0.531491050885599 0.27433423517803 no 947 0.2975392705612 1395 675225 SGTC_1125 tnp00248 1.32998 µM 0.530725604067219 0.274604862114252 no 948 0.297804470270232 1549 24207736 SGTC_618 k072-0232 33.2 µM 0.530639387669502 0.274635352533318 no 949 0.297834347896029 1442 5872756 YGL099W LSG1 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.52912006327478 0.275172935247271 no 950 0.298361082157541 1407 75037 A free radical scavenger. SGTC_65 0798-0905 34.986 µM 0.52880870202908 0.275283168167267 no 951 0.298469080254331 1639 3602145 SGTC_2426 5582046 32.21 µM 0.52840040832681 0.275427751544197 no 952 0.298610727084462 1478 2251934 SGTC_2110 5483698 200 µM 0.527359393497229 0.275796560642086 no 953 0.298972018238214 1443 2848765 YHR062C RPP1 SGTC_503 tyrphostin 8 294 µM 0.525587419811928 0.276424890266652 no 954 0.299587449665129 1474 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2484 5809818 12.04 µM 0.525281866022218 0.276533308452531 no 955 0.299693630806465 1453 2870548 SGTC_2799 7812892 81.82 µM 0.525195419326013 0.276563985702106 no 956 0.299723674466129 1511 20205235 SGTC_1736 st036774 51 µM 0.523362495833624 0.277214825757777 no 957 0.300361008982112 1599 1272247 SGTC_372 0155-0182 15.9 µM 0.518237993252691 0.279038415516436 no 958 0.30214611478172 1473 771486 SGTC_2160 5660466 132.927 µM 0.517976730148674 0.279131543874171 no 959 0.302237252505134 1461 2859134 SGTC_3105 9121040 49.47 µM 0.515747482824355 0.279926782630032 no 960 0.303015393224653 1374 41448907 SGTC_1041 0206-0046 107 µM 0.514645666750311 0.280320238444203 no 961 0.303400323705259 1482 50494 SGTC_1275 0867-0008 21.1 µM 0.514518686214071 0.280365600087966 no 962 0.303444699664972 1478 3422836 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.514013271900848 0.280546186003428 no 963 0.30362135582163 1591 6728940 SGTC_1878 temozolomide 1 mM 0.513452643576461 0.280746565862994 no 964 0.303817364481998 1550 5394 DNA alkylating agent. SGTC_1972 st070201 17.4 µM 0.513077900776334 0.280880545075761 no 965 0.303948414722768 1532 2829099 SGTC_2794 7785382 27.27 µM 0.512925632407405 0.280934993366751 no 966 0.304001671262499 1475 2205081 SGTC_316 k060-0003 58.6 µM 0.512620892613026 0.281043977876489 no 967 0.304108267853713 1487 6152314 SGTC_927 2425-1185 123 µM 0.511473242445713 0.281454596797871 no 968 0.304509860045231 1418 730375 SGTC_2685 mycophenolic acid 18.85 µM 0.509817602457681 0.282047479443352 no 969 0.305089626246728 1504 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3013 9080133 71.4286 µM 0.50772461849047 0.28279783404746 no 970 0.305823240516392 1539 17050193 SGTC_668 1682-0499 62.6 µM 0.506330433152958 0.283298194264422 no 971 0.306312351041611 1480 682214 SGTC_1312 1218-2183 165 µM 0.506123358396714 0.283372547675732 no 972 0.306385026844918 1473 6744073 SGTC_249 wiskostatin 11.211 µM 0.506016707504046 0.283410845987225 no 973 0.306422460450363 1497 2775510 A n-wasp and actin depolymerizer. SGTC_3162 9099653 49.47 µM 0.504025049273193 0.284126505467955 no 974 0.307121887257343 1472 25237511 SGTC_1215 3852-0577 11.2 µM 0.503093396519174 0.284461571261836 no 975 0.307449304607749 1581 2884876 SGTC_1420 4'-methoxyflavone 42 µM 0.502424744834652 0.284702165898333 no 976 0.30768438825226 1514 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2435 5706476 10.6 µM 0.502325202297436 0.284737991656656 no 977 0.307719392038082 1529 5725375 SGTC_80 0159-0065 512.242 µM 0.502023961709153 0.284846422458784 no 978 0.307825332901978 1466 1548079 SGTC_2598 perillyl alcohol 100 µM 0.499585221933569 0.285724965313527 no 979 0.308683582840743 1536 10819 An apoptosis inducer. SGTC_1324 1418-0026 34.4 µM 0.499554811334396 0.285735928700041 no 980 0.308694291659347 1506 1372513 SGTC_585 0kpi-0023 191 µM 0.49719543205266 0.286587122684186 no 981 0.309525621186129 1548 64601 SGTC_2105 5350118 200 µM 0.49701229784908 0.286653242335441 no 982 0.309590189550578 1470 2133313 SGTC_134 0269-0018 6.916 µM 0.496132179994109 0.2869711051874 no 983 0.309900578216388 1429 4378915 SGTC_48 0382-0018 55 µM 0.495575443093603 0.287172262138783 no 984 0.310096991049049 1612 762596 SGTC_1100 amiodarone 5.07 µM 0.494551508763077 0.287542398331552 no 985 0.310458369295685 1525 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_320 4092-0846 5.34 µM 0.492581320208952 0.288255224414223 no 986 0.311154224759344 1539 1359356 SGTC_2693 st077581 40.7 µM 0.492444817822875 0.288304642656315 no 987 0.311202461404229 1489 25238761 SGTC_2188 6126565 140.678 µM 0.490348134794658 0.289064210665741 no 988 0.311943785528247 1526 874518 SGTC_658 3253-0951 102 µM 0.490113712977819 0.289149193419825 no 989 0.312026717480098 1518 1184878 SGTC_2302 7771753 200 µM 0.489890252721132 0.289230213316645 no 990 0.312105780406286 1427 2203047 SGTC_3071 9117417 49.47 µM 0.48889530626014 0.289591080132621 no 991 0.312457909452432 1538 45595590 YGL055W OLE1 SGTC_1920 st075728 45.7 µM 0.487943069862728 0.289936653861622 no 992 0.31279508311168 1593 3400306 SGTC_1012 4112-3522 18 µM 0.483744617501062 0.291462604817456 no 993 0.31428356205859 1590 3112398 SGTC_27 0485-0001 32.618 µM 0.481830954862993 0.29215937689794 no 994 0.314963018836469 1484 2054479 SGTC_1453 4237-0541 195 µM 0.480874710966603 0.29250783923537 no 995 0.315302773631013 1577 739892 SGTC_1036 k216-0215 33.5 µM 0.480525465890651 0.292635154859592 no 996 0.315426899866327 1475 622330 SGTC_3176 9106582 49.47 µM 0.479732255359496 0.292924411559592 no 997 0.315708894561291 1477 17018027 SGTC_2143 5623677 140.463 µM 0.476782569360067 0.294001223368108 no 998 0.316758479547456 1504 5375313 SGTC_1637 st007924 17.4 µM 0.476183617467957 0.294220099968863 no 999 0.316971784888944 1486 683336 SGTC_2004 4023728 41.89 µM 0.476170897800251 0.294224748967428 no 1000 0.316976315417041 1583 360084 YDR527W RBA50 SGTC_1442 4112-3290 3 µM 0.475486796499409 0.294474835820287 no 1001 0.317220021010627 1495 704353 SGTC_2201 6605497 169.863 µM 0.473658260261379 0.295143774781092 no 1002 0.317871811302755 1574 670741 SGTC_129 0088-0017 176.636 µM 0.47310469705217 0.295346424380571 no 1003 0.318069242941101 1579 182446 SGTC_2774 tamoxifen 10.92 µM 0.471968271254673 0.295762650061452 no 1004 0.318474718018948 1538 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_201 4262-0159 12.803 µM 0.468734149685994 0.296948647043203 no 1005 0.319629836994794 1600 1341029 SGTC_2768 sulfasalazine 50.2 µM 0.468295833455069 0.297109550932082 no 1006 0.319786523801336 1660 5384001 An antioxidant and salicylic acid derivative. SGTC_1246 0422-0085 105 µM 0.466780100494379 0.297666276628953 no 1007 0.320328607231669 1594 264295 SGTC_2889 9059656 51.95 µM 0.466236287108433 0.297866134171589 no 1008 0.320523189034972 1593 3949838 SGTC_1871 st057448 67.3 µM 0.466043965775117 0.297936829070415 no 1009 0.32059201532132 1617 691747 SGTC_2279 7948423 32.93 µM 0.465345966121257 0.298193469181146 no 1010 0.320841861178669 1669 1247112 SGTC_3316 9136639 10.545 µM 0.464725675192175 0.298421621852076 no 1011 0.321063959662735 1608 4903665 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.46324161736723 0.298967803573947 no 1012 0.321595594241516 1560 2724278 An inhibitor of dopamine biosynthesis. SGTC_2754 granisetron 64.02 µM 0.460407915831241 0.300011957252731 no 1013 0.32261172695722 1640 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.460265078236613 0.300064633267693 no 1014 0.322662982045871 1544 17037758 SGTC_1529 apigenin 74 µM 0.459066581137852 0.30050678283316 no 1015 0.323093177097917 1626 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1891 st059073 26.2 µM 0.458835584220797 0.300592036028909 no 1016 0.323176119613228 1675 688754 SGTC_2132 5317594 122.667 µM 0.458452473492966 0.30073345338599 no 1017 0.323313699995326 1583 794577 SGTC_3059 1327-0034 3 µM 0.457805009022873 0.300972519646566 no 1018 0.323546268401263 1498 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_930 2810-3379 265 µM 0.456959544810342 0.301284823179541 no 1019 0.323850061845304 1694 1015764 SGTC_533 1222-0222 6.71 µM 0.4566136339914 0.301412640212194 no 1020 0.323974388878934 1643 3982874 SGTC_1915 st067105 30.6 µM 0.453536884451159 0.302550598080966 no 1021 0.325081094954314 1485 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_983 1491-0821 12.2 µM 0.453492168187399 0.302567150900865 no 1022 0.325097190797185 1616 46495113 SGTC_2253 7938677 135.83 µM 0.452847443992426 0.302805856448827 no 1023 0.325329298763883 1654 2301972 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.452706364842782 0.302858101463274 no 1024 0.325380097886414 1503 4174840 SGTC_37 0566-0070 1.56 µM 0.45191309914809 0.303151942011233 no 1025 0.32566579368821 1647 1626686 SGTC_1500 4488-1866 171 µM 0.448031281009648 0.304591675218063 no 1026 0.327065310603274 1648 2900003 SGTC_2748 diazoxide 86.69 µM 0.447825543936024 0.30466806615055 no 1027 0.327139553384171 1587 3019 A potassium channel activatior. SGTC_2066 5222451 176 µM 0.447253580864847 0.304880482895398 no 1028 0.327345989305178 1500 2281147 SGTC_1853 st056710 91.2 µM 0.446316349462391 0.30522869587632 no 1029 0.327684373948924 1712 269167 SGTC_2921 7974240 10.71 µM 0.445041110432076 0.305702773259804 no 1030 0.328145022579209 1612 2979074 YDR527W RBA50 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.44433778982736 0.305964376175881 no 1031 0.328399191715624 1528 390807 SGTC_1498 4478-3555 97.6 µM 0.44275150621939 0.30655476406151 no 1032 0.328972741454266 1600 3437919 SGTC_1317 1273-0028 910 nM 0.442015322759288 0.306828929850955 no 1033 0.329239058968651 1555 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_374 0880-0231 82.3 µM 0.440433426458043 0.307418417343356 no 1034 0.329811609791763 1569 6833587 SGTC_1965 Pectolinarigenin 58.4 µM 0.440043347044948 0.307563855485126 no 1035 0.329952856333269 1543 5320438 An anti-inflammatory. SGTC_1978 st071761 42 µM 0.438618849248302 0.308095225489733 no 1036 0.330468868373425 1512 5147680 SGTC_1182 1222-0449 220 µM 0.438572078016383 0.308112679051349 no 1037 0.330485816321818 1588 658318 SGTC_2994 9053520 71.4286 µM 0.438207668807351 0.308248680035442 no 1038 0.330617874960793 1676 4647384 SGTC_852 0418-0143 439 µM 0.438174205528338 0.3082611701696 no 1039 0.330630002811351 1602 5369229 SGTC_2097 5376186 200 µM 0.438156299508834 0.308267853663971 no 1040 0.330636492431589 1648 742755 SGTC_1052 3253-3998 198 µM 0.437105448095528 0.308660199475472 no 1041 0.33101743819934 1536 5450317 SGTC_2003 4023581 200 µM 0.435968940326727 0.309084771922902 no 1042 0.331429632376151 1568 16641307 SGTC_2602 kawain 100 µM 0.435067250330218 0.30942180355326 no 1043 0.3317568070536 1557 5369129 SGTC_1343 1487-0095 224 µM 0.433304421478241 0.310081172774075 no 1044 0.332396813207411 1644 4560101 YGL055W OLE1 SGTC_833 3852-0053 558 µM 0.433179705310338 0.310127844833726 no 1045 0.332442110742692 1638 3123681 SGTC_1183 1254-0324 198 µM 0.432169294592414 0.310506079743044 no 1046 0.332809187142169 1646 5799357 SGTC_2149 5554786 194.827 µM 0.430481320417635 0.311138399249715 no 1047 0.333422775935112 1595 745063 YPR165W RHO1 SGTC_1702 st027038 51 µM 0.430344384348178 0.311189720343116 no 1048 0.333472572600666 1590 5521182 SGTC_691 1548-0686 185 µM 0.429957841844175 0.311334609091792 no 1049 0.333613154229077 1534 46495133 SGTC_1160 4092-0570 10.5 µM 0.429452359741324 0.311524124389278 no 1050 0.333797028250011 1529 4994975 SGTC_1490 4089-0339 670 nM 0.429353648702493 0.311561138952226 no 1051 0.33383294000859 1660 742542 SGTC_1904 st060225 78 µM 0.429114544741613 0.311650805800274 no 1052 0.333919933991132 1540 66595 SGTC_427 1354-0053 47.3 µM 0.428946934238906 0.311713668404973 no 1053 0.333980921595078 1663 6813657 SGTC_493 zm226600 134 µM 0.427997366814929 0.312069908841093 no 1054 0.334326518742168 1612 5240098 A potassium channel opener. YCR052W RSC6 SGTC_734 2023-0417 80 µM 0.427897866168257 0.312107247762032 no 1055 0.334362740356751 1627 3935732 SGTC_2200 6600604 21.907 µM 0.427106071546051 0.312404447840164 no 1056 0.334651035431737 1552 2904777 SGTC_3165 9101544 49.47 µM 0.422808445412281 0.314019687086244 no 1057 0.336217512682203 1631 5002184 SGTC_620 0109-0052 432 µM 0.418868918271422 0.315503474393369 no 1058 0.337655966843234 1688 493037 SGTC_245 methotrexate 289.6 µM 0.418663414869282 0.31558095736577 no 1059 0.337731068416195 1636 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1850 st056238 17 µM 0.417705089235438 0.315942391342824 no 1060 0.338081375457634 1559 5393177 SGTC_115 0527-0192 112.043 µM 0.41665472373227 0.316338740495024 no 1061 0.338465487916935 1606 4233931 SGTC_1134 3477-0009 42.5 µM 0.416542756940507 0.316381002952614 no 1062 0.338506443434338 1785 3973534 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.414870685242509 0.317012420328382 no 1063 0.339118285389374 1656 5357218 A potent inhibitor of glutathione S-transferases. SGTC_828 2074-0507 139 µM 0.414511175322865 0.317148250253475 no 1064 0.339249892223446 1699 X828 SGTC_83 0170-0301 39.027 µM 0.413965175911593 0.317354586699749 no 1065 0.33944980531321 1619 3089716 SGTC_3143 9086658 49.47 µM 0.412600816195633 0.317870434486736 no 1066 0.33994955158344 1591 25236626 SGTC_993 3909-8757 62.7 µM 0.410337935499607 0.318726781476379 no 1067 0.340779033816698 1621 4288324 YLR208W SEC13 SGTC_3261 9137475 49.47 µM 0.408887943927706 0.319276014701347 no 1068 0.341310948462696 1608 17027690 SGTC_2905 7799065 20.05 µM 0.408350766145098 0.319479589717136 no 1069 0.341508086794488 1702 1296806 SGTC_2050 5263056 171 µM 0.408133944873405 0.319561774196749 no 1070 0.341587670067773 1741 763468 YGL055W OLE1 SGTC_2085 5307070 144.047 µM 0.404168642754719 0.321066351996778 no 1071 0.343044355396089 1579 2840351 SGTC_195 4234-0266 16.654 µM 0.402725035174663 0.321614840428461 no 1072 0.343575257287225 1614 2303354 SGTC_1513 0337-0559 19 µM 0.402507078310725 0.321697685422802 no 1073 0.343655440068294 1547 775073 SGTC_537 1334-0398 209 µM 0.40234179155763 0.321760516518616 no 1074 0.343716251063569 1735 5846986 SGTC_2467 5474540 200 µM 0.401911808002892 0.321923991713537 no 1075 0.343874466154451 1582 5413519 SGTC_1638 st008370 60.6 µM 0.401538297697756 0.322066024354672 no 1076 0.344011923760208 1570 24207134 SGTC_283 0987-0079 11.7 µM 0.401401694769583 0.322117976066334 no 1077 0.344062200913762 1710 411556 SGTC_1007 4101-0031 70 µM 0.401078719715 0.32224082112797 no 1078 0.344181083900073 1724 1146276 SGTC_1798 st045719 60.953 µM 0.400274477994217 0.322546802558989 no 1079 0.344477181890261 1668 3980186 SGTC_2162 5663267 200 µM 0.399041854174532 0.323015999340147 no 1080 0.344931182459482 1721 6456493 SGTC_452 diindolylmethane 8 µM 0.398391385242429 0.323263713193618 no 1081 0.345170853547629 1668 3071 Inhibits expression of several cancer promoting factors. SGTC_357 1325-0123 420 µM 0.398276455699621 0.32330748921481 no 1082 0.345213206823888 1731 1098503 SGTC_2999 9069765 71.4286 µM 0.397221478329935 0.323709438438231 no 1083 0.345602072470508 1695 2097066 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.396544964101608 0.323967300478446 no 1084 0.345851522044058 1729 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_153 4077-0274 519.67 µM 0.396255050426291 0.324077830650093 no 1085 0.345958441755058 1754 3121976 SGTC_2190 6049624 200 µM 0.395061047306844 0.324533210124927 no 1086 0.346398917630437 1686 2265554 SGTC_1827 berberine 7.24 µM 0.392560591650893 0.32548770579765 no 1087 0.347322025432095 1508 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_782 0083-0095 30.5 µM 0.39228171342898 0.325594232741701 no 1088 0.347425036814356 1631 3591729 An indicator and reagent. SGTC_2645 abamectin 100 µM 0.39145941529205 0.325908420157716 no 1089 0.347728840948942 1703 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_159 3970-0959 50 µM 0.390530237492195 0.326263593456722 no 1090 0.34807225026196 1686 6615653 SGTC_2709 st078560 56 µM 0.390090288090933 0.326431816792276 no 1091 0.348234892045022 1755 17250903 SGTC_2801 7907800 81.82 µM 0.389165579346963 0.326785512496394 no 1092 0.348576832047306 1631 6620925 SGTC_1148 3909-7663 27.7 µM 0.389062064972664 0.326825115837574 no 1093 0.348615117391633 1720 4084526 SGTC_225 nsc-122657 1.016 µM 0.386375159211456 0.327853774760046 no 1094 0.34960942227765 1682 275685 SGTC_1526 st051518 75 µM 0.385059084432917 0.328358100325185 no 1095 0.350096820497672 1631 673993 SGTC_1296 1068-0102 11.9 µM 0.383822482313573 0.328832256827521 no 1096 0.35055501177156 1723 767053 SGTC_862 0452-0056 10.2 µM 0.383789679342352 0.328844838389975 no 1097 0.350567169037493 1661 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_3355 9151058 44.0485 µM 0.381717424815448 0.329640043165395 no 1098 0.35133548696091 1644 17015728 SGTC_1363 1636-0063 10.4 µM 0.381462329488789 0.329737986534552 no 1099 0.351430109277467 1664 6072185 SGTC_1893 st059353 36.1 µM 0.379902166541426 0.330337262040303 no 1100 0.352009019518436 1614 3112488 SGTC_2764 methyldopa 94.69 µM 0.379633893118035 0.330440352685259 no 1101 0.352108599014734 1759 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1098 clofazimine 15.1 µM 0.377031896112331 0.331440900561942 no 1102 0.353074950712008 1722 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1685 st024049 53.0905 µM 0.375620195981523 0.331984247067201 no 1103 0.353599637123455 1662 1941139 SGTC_3280 9140961 49.47 µM 0.374568778904437 0.332389154699689 no 1104 0.353990598049048 1654 4901226 SGTC_1552 6-methylflavone 10.6 µM 0.37417708052366 0.332540050379421 no 1105 0.354136287312763 1772 689013 SGTC_53 0973-0023 39.979 µM 0.373126859330456 0.332944765560575 no 1106 0.354527014509961 1829 674768 SGTC_3127 9126946 49.47 µM 0.373122802704949 0.332946329207022 no 1107 0.354528524045282 1598 27243249 SGTC_2564 betulinic acid 100 µM 0.371796937524931 0.333457546018478 no 1108 0.355022022001602 1871 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_410 α-linolenic acid 100 µM 0.371335707176522 0.333635456237665 no 1109 0.355193752827038 1752 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_608 k048-0125 159 µM 0.371004404820601 0.333763272471875 no 1110 0.355317125455828 1761 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1784 st039334 36.3 µM 0.370901807403449 0.333802858401974 no 1111 0.35535533445703 1766 3496984 SGTC_495 decylubiquinone 155 µM 0.36967331244821 0.334277001391614 no 1112 0.35581295945158 1642 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_109 0132-0036 33.701 µM 0.366731660698016 0.335413418702591 no 1113 0.356909593862284 1697 67274 A color developer. SGTC_2973 9094665 17.96 µM 0.366601702904277 0.335463658773379 no 1114 0.356958068899682 1785 25237061 YIL048W NEO1 SGTC_2644 guaiazulene 100 µM 0.366029894514409 0.335684747745514 no 1115 0.357171384289799 1752 3515 A coloring agent. SGTC_2639 lactacystin 53 µM 0.364454110275085 0.336294316905534 no 1116 0.357759467748293 1768 3870 A proteasome inhibitor. SGTC_3311 9131146 2.8755 µM 0.363996613656997 0.3364713735345 no 1117 0.357930269048643 1670 4900406 YPR165W RHO1 SGTC_352 k048-0007 5.11 µM 0.36375320378209 0.336565590832809 no 1118 0.358021155027426 1679 6811911 SGTC_2986 9022445 71.43 µM 0.363669893614051 0.336597840275255 no 1119 0.358052263774258 1805 6459286 SGTC_477 mead ethanolamide 10 µM 0.359629338447508 0.338163381623349 no 1120 0.35956217031161 1678 16061185 SGTC_554 4483-2211 187 µM 0.359502884222242 0.338212422561142 no 1121 0.359609460269164 1700 747107 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.359139188822937 0.338353484656733 no 1122 0.359745483047648 1665 279621 SGTC_3196 9111891 49.47 µM 0.359002635183201 0.338406453910108 no 1123 0.359796558960266 1672 18891510 SGTC_2545 solidagenone 89.61 µM 0.358045425571709 0.338777845912765 no 1124 0.360154659609711 1667 6708572 An anti ulcer agent SGTC_1846 st056244 14.8 µM 0.357962774641233 0.33880992137275 no 1125 0.360185585820839 1732 5393182 SGTC_1307 1187-1599 12.2 µM 0.356036772656543 0.33955770146379 no 1126 0.360906513290651 1676 1538471 SGTC_278 4092-0821 23.9 µM 0.355500952712411 0.339765848795797 no 1127 0.361107165657796 1754 877900 SGTC_1253 0550-0034 176 µM 0.354918612008057 0.339992123235726 no 1128 0.361325282335585 1679 5969915 SGTC_1990 st072050 59.8 µM 0.353120722557067 0.340691075032418 no 1129 0.36199896900139 1657 17233948 SGTC_3253 9135987 49.47 µM 0.353059970158936 0.340714702853252 no 1130 0.362021740999479 1729 4182430 SGTC_3245 9134821 49.47 µM 0.352884174583574 0.340783076783577 no 1131 0.362087637717647 1615 17014901 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.352546957820522 0.340914248509769 no 1132 0.362214054376115 1801 688798 SGTC_1239 0337-0584 35.4 µM 0.351880110255618 0.341173697762526 no 1133 0.362464088085223 1828 914301 YML130C ERO1 SGTC_1740 st038286 13.222 µM 0.351589345227647 0.34128684874074 no 1134 0.362573128466204 1733 716786 SGTC_2557 derrustone 83.84 µM 0.350961018683079 0.341531410241025 no 1135 0.362808796536311 1641 629853 An antioxidant. SGTC_1131 3454-3128 32.3 µM 0.350035319035611 0.341891838530672 no 1136 0.363156095779123 1794 710982 SGTC_359 0081-0058 15.9 µM 0.350000761452652 0.341905296584941 no 1137 0.363169063096662 1842 3494159 SGTC_399 oxolinic acid 75 µM 0.346897600104998 0.343114604311159 no 1138 0.364334124835017 1702 4628 A DNA gyrase inhibitor. SGTC_2369 9071472 200 µM 0.346876936501605 0.343122662360362 no 1139 0.364341887067165 1756 17296037 SGTC_1714 st033236 13.627 µM 0.345974950396852 0.343474473411986 no 1140 0.364680770124696 1807 2916566 SGTC_1883 5-benzylidenerhodanine 20 µM 0.345820467088719 0.343534741762775 no 1141 0.364738821297193 1824 1273210 SGTC_757 1066-0008 322 µM 0.34469380178902 0.343974406288979 no 1142 0.365162289175174 1771 6842497 SGTC_1406 3909-7906 11.9 µM 0.343110230718551 0.344592728243291 no 1143 0.36575776740072 1748 X1406 SGTC_453 enantio-paf c16 10 µM 0.340891600856599 0.34545971408557 no 1144 0.366592594033199 1711 13871343 A lipid and platelet activating factor SGTC_1658 st012944 20 µM 0.338876041824427 0.346248048472259 no 1145 0.367351556770936 1794 24207260 SGTC_1040 k898-0338 155 µM 0.338421808604701 0.346425802351886 no 1146 0.367522670886753 1887 20969351 SGTC_1185 1319-0113 81.3 µM 0.337831239651502 0.346656958708152 no 1147 0.367745183342396 1774 4672763 SGTC_2311 7694451 200 µM 0.336888132217543 0.347026221584306 no 1148 0.368100616020574 1777 2163142 SGTC_1451 4152-0210 104 µM 0.336139718497 0.347319357806725 no 1149 0.368382754090989 1836 659563 SGTC_1369 1866-0067 208 µM 0.336117539576553 0.347328046167831 no 1150 0.368391116215706 1820 3531355 SGTC_2648 atorvastatin 78.68 µM 0.335476746179136 0.347579104934955 no 1151 0.368632741637475 1811 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1718 roemerine 11.9335 µM 0.334627869682611 0.34791179228592 no 1152 0.368952909401821 1724 235224 An aporphine alkaloid with mutagenic activity. SGTC_3328 9140624 29.0385 µM 0.332697836329504 0.348668636639224 no 1153 0.369681191479348 1843 4904392 SGTC_2257 7960413 200 µM 0.332583115483767 0.348713642341183 no 1154 0.369724495191928 1794 2974689 YIL048W NEO1 SGTC_2842 9000675 19.48 µM 0.331695666781722 0.349061865887224 no 1155 0.370059536512495 1628 2989072 SGTC_1409 3909-8004 61.9 µM 0.329518712465104 0.349916612933442 no 1156 0.370881826249005 1749 2119279 SGTC_1514 1189-1591 158 µM 0.328958379489332 0.35013674224442 no 1157 0.371093573563637 1806 767698 YMR146C TIF34 SGTC_217 ketoconazole 989 nM 0.328669858699064 0.350250108572488 no 1158 0.371202619502175 1755 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_847 0342-0274 5.54 µM 0.325918017256703 0.351332038463962 no 1159 0.372243191778116 1848 18097 SGTC_968 1309-0633 340 µM 0.325238527175749 0.351599376684569 no 1160 0.372500275932393 1856 3761976 SGTC_894 0960-0238 55.9 µM 0.322310257207466 0.352752312103602 no 1161 0.37360883164978 1818 6741907 YDL195W SEC31 SGTC_1073 triclabendazole 3.09 µM 0.321775356228891 0.352963062945962 no 1162 0.373811442534272 1759 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2856 9022925 19.48 µM 0.321508036427986 0.353068403788363 no 1163 0.373912711547323 1763 4944862 SGTC_3310 9130229 44.1445 µM 0.320082778110029 0.353630235263858 no 1164 0.374452790261666 1837 7761258 SGTC_3337 9144342 33.5465 µM 0.317774146589822 0.354540965555109 no 1165 0.375328131500643 1820 17682949 SGTC_1329 1447-1697 50.6 µM 0.317053086475267 0.35482558681491 no 1166 0.375601660666575 1757 2840515 SGTC_760 0568-0725 82.9 µM 0.316253603210963 0.355141258490247 no 1167 0.375905012218941 1880 3916171 SGTC_1087 pterostilbene 9.05 µM 0.315922271257846 0.355272112292041 no 1168 0.376030753493954 1863 5281727 Similar to reservatol, lowers cholesterol. SGTC_118 0083-0097 135.343 µM 0.315730982123594 0.355347666385912 no 1169 0.37610335417566 1749 5207356 SGTC_1929 genistein trimethyl ether 50.5 µM 0.314942634771213 0.355659102486525 no 1170 0.376402604846849 1934 136420 SGTC_1150 3909-7983 10.9 µM 0.313774238865083 0.356120853743821 no 1171 0.376846255692241 1733 23965914 SGTC_859 0439-0102 54.6 µM 0.313565709347423 0.356203287040591 no 1172 0.376925453422619 1886 610143 SGTC_701 4424-0219 185 µM 0.311881607531226 0.35686927125093 no 1173 0.377565250443261 1895 2911779 SGTC_1807 st050092 58.9 µM 0.311391013507922 0.357063360632097 no 1174 0.377751692371163 1753 5008496 SGTC_1165 k072-0275 30.3 µM 0.310504553673279 0.357414156700702 no 1175 0.378088648584735 1821 6153523 YGL055W OLE1 SGTC_550 4123-0385 25.7 µM 0.310309915581021 0.357491196390634 no 1176 0.378162645768611 1743 5731123 SGTC_123 0083-0120 66.675 µM 0.308804574021191 0.358087221469591 no 1177 0.378735094763182 1700 16001701 SGTC_1751 st044839 27.194 µM 0.308390489844241 0.358251234745409 no 1178 0.378892608791202 1826 5291326 SGTC_99 0109-0120 622.8 µM 0.308061425858111 0.358381591301373 no 1179 0.379017796222013 1854 759414 SGTC_3160 9100216 49.47 µM 0.307935570815501 0.358431452321689 no 1180 0.379065679230753 1838 17191039 SGTC_1727 st034309 9.9045 µM 0.307848330721397 0.358466016358923 no 1181 0.379098871824125 1902 870305 SGTC_2476 5806916 10.51 µM 0.307699084733806 0.358525149472732 no 1182 0.379155658118846 1818 2870194 SGTC_3281 9140613 49.47 µM 0.306909814645426 0.358837924458679 no 1183 0.37945600918485 1677 16013766 SGTC_3208 9114115 49.47 µM 0.306490817556978 0.359004004721198 no 1184 0.379615485096919 1656 650895 SGTC_2940 9060638 45.86 µM 0.306467283826265 0.359013333710941 no 1185 0.379624442958216 1779 4027022 SGTC_710 3448-4187 58 µM 0.306378715382394 0.359048443819502 no 1186 0.37965815616217 1761 3946412 SGTC_117 lucigenin 22.078 µM 0.304913818828101 0.35962932740411 no 1187 0.380215895364055 1673 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2667 digitoxin 100 µM 0.304594180439474 0.35975611856245 no 1188 0.380337626436093 1889 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.304248478661207 0.359893265677384 no 1189 0.380469296829503 1837 804 An inhibitor of viral and cellular DNA polymerases. SGTC_52 0329-0193 875 nM 0.303846806014341 0.360052640262049 no 1190 0.380622302720194 1862 3739292 SGTC_1796 st049173 110.4 µM 0.301576797931323 0.36095378446258 no 1191 0.381487348755486 1869 94134 SGTC_763 3453-1109 128 µM 0.301572442641242 0.360955514162662 no 1192 0.381489009023524 1903 1560353 SGTC_2170 morpholine 200 µM 0.301030749573993 0.361170669305847 no 1193 0.381695523326584 1864 121171 Reacts with secondary amines. SGTC_1483 3453-0561 55.9 µM 0.300938610649182 0.361207270350984 no 1194 0.381730653593633 1838 4546991 SGTC_3181 9108277 49.47 µM 0.300589878675625 0.36134581130502 no 1195 0.38186362518941 1745 17097298 SGTC_3100 9120536 49.47 µM 0.300486294075085 0.361386965923244 no 1196 0.38190312471143 1886 16421196 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.296097249159859 0.363132221135426 no 1197 0.383577907350765 1750 2374 Ca(2+)-ATPase inhibitor. SGTC_1470 k295-0292 231 µM 0.294400658312393 0.363807616403707 no 1198 0.384225881963496 1868 5045612 SGTC_2345 9052315 157.45 µM 0.293987122315398 0.363972305062044 no 1199 0.384383871847047 1778 6469265 SGTC_2207 7258803 200 µM 0.293610630124052 0.364122263062186 no 1200 0.384527725988328 1861 3666799 SGTC_314 1671-0008 2.74 µM 0.293122228799095 0.364316825815485 no 1201 0.384714363254841 1813 3913060 SGTC_2191 5911152 200 µM 0.292380709982885 0.364612288946372 no 1202 0.384997777692825 1804 2875902 SGTC_3294 9122953 26.2835 µM 0.290096664891147 0.365522886812314 no 1203 0.385871143590107 1757 16459826 SGTC_541 4513-1321 94 µM 0.289348707983614 0.365821245662791 no 1204 0.386157270998064 1748 747515 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.289328627345014 0.365829256918106 no 1205 0.386164953606515 1896 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3246 9135460 32.98 µM 0.289297798644623 0.365841556271788 no 1206 0.386176748379738 1873 41446951 SGTC_49 0717-0965 32.132 µM 0.28565269653439 0.367296767394946 no 1207 0.387572069145971 1886 5889349 YGL099W LSG1 SGTC_2946 9065502 71.43 µM 0.284520320591684 0.367749228142171 no 1208 0.388005831827383 1820 16489101 SGTC_221 trifluoperazine 10.304 µM 0.283366819303665 0.368210318669045 no 1209 0.388447830392 1807 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1616 st002734 56.1 µM 0.283202626597051 0.368275967081597 no 1210 0.388510757505431 1844 4026101 SGTC_2708 st078559 56 µM 0.282164432129926 0.368691152559621 no 1211 0.388908714852221 1857 17250902 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.281653870512775 0.368895388080213 no 1212 0.389104464473848 1941 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2100 5377183 190 µM 0.281205232826652 0.369074883275106 no 1213 0.389276495662484 1893 2844202 SGTC_1372 2752-0194 270 µM 0.280101268763414 0.369516689131875 no 1214 0.389699905660183 1792 823334 SGTC_1068 loratadine 26.9 µM 0.27928357943304 0.369844039128641 no 1215 0.39001360342433 1784 3957 A H1 histamine antagonist. SGTC_2178 5812956 200 µM 0.278621243003315 0.370109265025491 no 1216 0.390267754240415 1829 5403383 SGTC_1042 0350-0096 82 µM 0.278311845947659 0.370233181112256 no 1217 0.390386491728838 1766 3122515 SGTC_2090 5301565 104.445 µM 0.275452314767312 0.371379083047669 no 1218 0.391484378261178 1827 2056344 SGTC_3109 9122853 49.47 µM 0.273953117943845 0.37198031382229 no 1219 0.392060325110922 1885 1234709 SGTC_2882 9058044 58.44 µM 0.273766755301667 0.372055073663866 no 1220 0.39213193665547 1730 18076804 SGTC_3269 9137823 49.47 µM 0.273329567763802 0.372230471467292 no 1221 0.392299944288414 1784 17682936 SGTC_955 1216-0110 33 µM 0.273170900120175 0.372294134817861 no 1222 0.392360923947046 1766 3619719 SGTC_2677 mitomycin C 100 µM 0.272432755570317 0.37259035168423 no 1223 0.392644644759408 1832 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1703 st026983 48.3 µM 0.272300986850438 0.372643238308484 no 1224 0.392695298742825 1946 1104023 SGTC_1713 st033146 12.748 µM 0.271258684114677 0.373061660927738 no 1225 0.393096040410266 1936 674619 SGTC_3104 9120930 49.47 µM 0.269037821809815 0.373953704183108 no 1226 0.393950288847897 1840 17014836 SGTC_198 3454-2873 16.191 µM 0.268881097820004 0.374016680337734 no 1227 0.394010591621647 1846 710957 SGTC_2148 5546263 113.568 µM 0.268237220011012 0.374275444016145 no 1228 0.394258363483366 1837 792097 SGTC_864 0469-0573 172 µM 0.268083525720705 0.374337219549535 no 1229 0.394317513210344 1773 689425 SGTC_2334 9017922 200 µM 0.267226796525757 0.374681630408976 no 1230 0.39464727273397 1934 3163164 SGTC_1304 1165-0502 251 µM 0.26658782074638 0.374938568056003 no 1231 0.394893267004469 1877 767425 SGTC_1345 1488-0192 31.4 µM 0.265321431355891 0.375447958050173 no 1232 0.395380928058917 1934 658348 SGTC_2621 lithochol-11-enic acid 100 µM 0.264087912745971 0.375944335031026 no 1233 0.395856088800004 1983 6708711 SGTC_2121 5257820 149.641 µM 0.262604123000615 0.376541694962533 no 1234 0.396427860937802 1973 791256 SGTC_1019 4262-0212 3.4 µM 0.262389843904354 0.376627986205185 no 1235 0.396510450927683 1978 4677213 SGTC_3259 9138485 49.47 µM 0.261687783367202 0.376910752592498 no 1236 0.396781079936901 1936 17646153 SGTC_1045 1348-1485 165 µM 0.26085031666119 0.377248142391171 no 1237 0.397103970092621 1900 6810614 SGTC_248 streptozotocin 5.23457 mM 0.260032494591244 0.377577708420762 no 1238 0.397419354227752 1970 5300 DNA alkylating agent. SGTC_2016 5121758 140 µM 0.259939033855695 0.377615376919282 no 1239 0.397455400612528 1876 2795203 SGTC_2077 5212015 200 µM 0.259227092118912 0.377902356736662 no 1240 0.397730014438484 1887 780900 SGTC_77 0828-0286 12.516 µM 0.259087379798994 0.37795868192372 no 1241 0.397783910946007 1952 745345 SGTC_444 curcumin 90.4 µM 0.258340654685042 0.378259768999221 no 1242 0.398072006469659 1892 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1708 st033234 31.827 µM 0.25780844142537 0.37847440787908 no 1243 0.398277374675208 1943 674664 SGTC_1257 0669-0121 16 µM 0.25751647444789 0.378592172597423 no 1244 0.398390049633388 1934 4307855 SGTC_1530 rhein 70.4 µM 0.257223326398349 0.378710425044408 no 1245 0.398503188910499 1915 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1693 xanthone 101.9 µM 0.255957233700585 0.379221282135687 no 1246 0.398991930029113 1911 7020 An insecticide. SGTC_1757 st041620 31.8375 µM 0.255327802125639 0.379475330728666 no 1247 0.399234964199661 1822 5289815 SGTC_1876 myriocin 605 nM 0.255017741762023 0.379600495162657 no 1248 0.399354698112911 1971 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.253434641929015 0.380239753569211 no 1249 0.399966180415915 1823 6708784 An antioxidant flavonoid SGTC_1356 1502-0781 85.8 µM 0.252420940492035 0.380649259921565 no 1250 0.400357857953429 1838 567702 SGTC_1462 k081-0014 26.5 µM 0.251460315142891 0.381037448504642 no 1251 0.400729120271131 1822 3270634 SGTC_2981 9013952 38.96 µM 0.250034830819303 0.381613707142534 no 1252 0.40128020640841 1738 2996344 SGTC_2474 5321570 43.32 µM 0.248827907648739 0.382101816693582 no 1253 0.401746951362556 1964 2841384 SGTC_2982 9019404 25.97 µM 0.247434473621362 0.382665588944584 no 1254 0.402285998677392 1655 22333232 SGTC_1502 4534-4282 27.7 µM 0.247273252495889 0.382730833797654 no 1255 0.402348378780982 1872 3278949 SGTC_619 1652-1634 108 µM 0.244705553608509 0.38377040769498 no 1256 0.403342213801693 1847 5400454 SGTC_1450 4112-4260 37.6 µM 0.241004199943789 0.385270431209955 no 1257 0.404775930686251 1984 1633175 SGTC_1651 st011928 86.1 µM 0.239133090995849 0.38602937862861 no 1258 0.405501191553062 1918 720198 SGTC_718 1130-0073 349 µM 0.237769675832958 0.386582673514539 no 1259 0.406029869707431 1944 6740020 SGTC_3298 9116858 71.43 µM 0.235976189743787 0.387310848915809 no 1260 0.406725573154572 1964 2506942 SGTC_539 4859-0462 2.54 µM 0.232127378587622 0.388874845308483 no 1261 0.408219540268775 2022 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1565 sinapyl alcohol 95.1 µM 0.232117168944069 0.388878996490335 no 1262 0.408223505062429 1832 5280507 A phenol propionate derived from cinnamic acid. SGTC_148 3253-0744 288.01 µM 0.231780421308157 0.389015923233495 no 1263 0.408354282265516 1969 6893655 SGTC_85 0868-0259 160.055 µM 0.231595888731768 0.389090962851725 no 1264 0.408425950511668 1911 83173 SGTC_939 1165-0479 45.3 µM 0.230598408719794 0.389496656658789 no 1265 0.40881340197767 2020 1377347 SGTC_3256 9138902 49.47 µM 0.230217810220021 0.389651484972137 no 1266 0.40896126148169 1962 17228773 SGTC_2217 6934799 96.0675 µM 0.229073889900084 0.39011693963102 no 1267 0.409405743378053 1995 675606 SGTC_2307 7538926 6.34 µM 0.228775408578611 0.390238415929426 no 1268 0.409521740522273 1875 96582 SGTC_2402 5553605 200 µM 0.227598873161579 0.390717348052941 no 1269 0.409979048025378 1962 6758546 SGTC_2853 9015042 58.44 µM 0.227594743454423 0.390719029424789 no 1270 0.409980653417133 1867 6457456 SGTC_726 3448-4391 34.2 µM 0.226819604023975 0.391034656382987 no 1271 0.410282009575781 1975 1356692 SGTC_2281 7943571 200 µM 0.224498574618398 0.39198017867198 no 1272 0.4111846879516 2076 1244024 SGTC_2021 4019055 173 µM 0.224400545288698 0.392020127158701 no 1273 0.411222823214155 1939 44827708 YER133W GLC7 SGTC_1976 st070609 63.5 µM 0.223699806087167 0.3923057224816 no 1274 0.411495448421971 1963 682556 SGTC_2818 7996756 12.99 µM 0.223068213230427 0.392563186034777 no 1275 0.411741208610148 1892 2241621 SGTC_1114 scopoletin 1.73284 µM 0.222319190272314 0.392868579933558 no 1276 0.412032707103424 2026 5280460 A coumarin with genotoxic properties. SGTC_1621 st003705 32.4 µM 0.222156274573608 0.392935013153129 no 1277 0.412096115706158 2041 24207032 SGTC_266 formosanin C 406 nM 0.221397361724128 0.393244521171605 no 1278 0.412391523251754 2008 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3247 9135149 49.47 µM 0.219731967376685 0.393923956532697 no 1279 0.413039953338893 1936 8934436 YOR116C RPO31 SGTC_2751 anetholtrithion 17.25 µM 0.219101387706655 0.394181300215154 no 1280 0.413285534900689 2001 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2828 7998861 71.43 µM 0.218558927256253 0.39440271884304 no 1281 0.413496825263909 2036 2988188 SGTC_1772 st048439 82.2 µM 0.218444846886262 0.39444928790827 no 1282 0.41354126318257 1894 2927068 YDL195W SEC31 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.216928252339103 0.395068524280707 no 1283 0.414132129815998 1904 688788 SGTC_944 3370-0224 231 µM 0.216865204132847 0.395094273063615 no 1284 0.414156697673519 1867 4580514 SGTC_2941 9056145 11.23 µM 0.214378511746667 0.396110198372341 no 1285 0.415125948641999 2057 2119517 SGTC_3288 9119690 36.221 µM 0.214231121155873 0.396170436265617 no 1286 0.415183414116958 1870 17595618 YKL019W RAM2 SGTC_1219 1469-0211 33.1 µM 0.213077490281187 0.396642005719466 no 1287 0.41563326081902 2020 6822282 SGTC_1043 0916-0009 19.3 µM 0.212360633534315 0.396935111324648 no 1288 0.415912847611537 2095 3101130 SGTC_1553 gossypol 38.6 µM 0.212241091222672 0.396983994990591 no 1289 0.415959475369078 2006 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.212063589980732 0.397056582413668 no 1290 0.416028712324881 2047 16623 A steroid. SGTC_2027 5150920 200 µM 0.211801457957928 0.397163785300905 no 1291 0.416130965520494 2009 786715 SGTC_2786 7743617 45.45 µM 0.211765784094614 0.397178375272043 no 1292 0.416144881720315 1845 583674 SGTC_2283 7944793 200 µM 0.2107860991206 0.397579105046492 no 1293 0.416527093071798 1871 2970533 SGTC_81 0411-0046 9.971 µM 0.210592243050349 0.397658412647165 no 1294 0.416602732862721 1965 12925265 SGTC_946 3434-1334 87.4 µM 0.210542241249328 0.397678869349504 no 1295 0.41662224333205 1991 4047976 SGTC_597 k018-0003 82.8 µM 0.21007602631795 0.397869620415772 no 1296 0.416804168101361 2008 6786234 SGTC_980 1473-0395 201 µM 0.209946991237705 0.397922419221079 no 1297 0.416854522871612 1886 768876 SGTC_1220 1838-0075 193 µM 0.209837308288237 0.397967300956863 no 1298 0.416897326720915 1979 5529645 SGTC_229 benomyl 22.8748 µM 0.209717992874094 0.398016125784207 no 1299 0.416943890765157 1945 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2989 9073649 71.4286 µM 0.209346366738315 0.398168208419302 no 1300 0.417088929077659 2084 21367202 SGTC_3222 9128301 49.47 µM 0.207931629816797 0.398747310464909 no 1301 0.417641175930137 1925 4911358 SGTC_2516 gossypol 71.55 µM 0.206264836864862 0.399429874034661 no 1302 0.418292022016589 2018 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1005 4092-0690 4.4 µM 0.205307337505582 0.399822116042213 no 1303 0.418666005833156 1906 1529343 SGTC_671 0560-0003 407 µM 0.204567692517055 0.400125182702542 no 1304 0.418954949596386 1993 3238678 SGTC_1227 3909-8010 46.6 µM 0.20431699323907 0.400227919417793 no 1305 0.419052895689168 1954 15982272 SGTC_727 3032-0951 202 µM 0.203991090573692 0.400361484847771 no 1306 0.419180230610425 1951 3652836 SGTC_648 0375-0473 33.3 µM 0.203863027621319 0.400413972368737 no 1307 0.419230268989969 1953 1713139 SGTC_538 2922-0838 53.3 µM 0.203611032895963 0.400517259467678 no 1308 0.41932873537603 2065 777039 SGTC_2061 5245884 80.95 µM 0.202813804073977 0.400844071825476 no 1309 0.419640284036558 1933 573863 SGTC_806 3966-4455 5.86 µM 0.20178513124878 0.401265863817329 no 1310 0.420042352997422 1885 714982 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.20091208217703 0.401623934914699 no 1311 0.420383660067334 1940 65057 A dermal irritant. YDR527W RBA50 SGTC_3155 9099265 49.47 µM 0.200746169291808 0.401691991538771 no 1312 0.420448528308887 1983 25236499 SGTC_3334 9142812 21.919 µM 0.200622270445252 0.401742816162057 no 1313 0.420496971406654 1995 45283678 SGTC_3175 9106517 49.47 µM 0.199994758866789 0.402000253585848 no 1314 0.420742340068822 1929 41468073 SGTC_2991 9074669 71.4286 µM 0.198504730517026 0.402611709783787 no 1315 0.42132509198905 2021 17333109 SGTC_140 0062-0056 502.533 µM 0.197156108384361 0.403165343265191 no 1316 0.42185268842431 1977 3758964 SGTC_737 1950-0117 57.9 µM 0.196175338093482 0.403568089006726 no 1317 0.422236465172631 2080 5393513 SGTC_1663 st014140 55.4 µM 0.195079545263153 0.404018188827993 no 1318 0.422665337726228 2063 4207120 SGTC_738 1315-0003 72.4 µM 0.194039385649885 0.404445554760985 no 1319 0.423072521324559 2057 6251474 SGTC_2272 7805186 180 µM 0.193398792508739 0.404708809301455 no 1320 0.42332333051129 2096 2956062 YPR165W RHO1 SGTC_1414 3917-0015 5.4 µM 0.19207814344447 0.405251671802418 no 1321 0.42384049756747 2039 6618702 SGTC_2274 7947094 46.08 µM 0.19041927025813 0.405933822074118 no 1322 0.424490299222257 2118 2971028 SGTC_3134 9127454 49.47 µM 0.189002349663814 0.406516704613859 no 1323 0.425045487608421 2106 24262820 SGTC_3031 9088762 49.47 µM 0.187051740942613 0.407319470635826 no 1324 0.425810032693213 2024 205253 SGTC_3149 9097855 49.47 µM 0.187014374286137 0.407334852561354 no 1325 0.425824681363312 2062 25236625 YMR079W SEC14 SGTC_2096 5468907 200 µM 0.186987963573692 0.407345724575898 no 1326 0.425835035089266 2078 759785 SGTC_1939 st074455 53.6 µM 0.186778498999621 0.40743195355011 no 1327 0.425917152775925 2095 1644229 SGTC_2556 citropten 84.59 µM 0.186108469006522 0.40770781072035 no 1328 0.426179850317823 1961 2775 A potential DNA crosslinker. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.185758251833487 0.407852016394647 no 1329 0.426317172424665 1967 5379071 SGTC_2487 5918373 44.05 µM 0.185514988585164 0.407952189993186 no 1330 0.42641256256005 2122 2876279 SGTC_3074 9116018 49.47 µM 0.185030385827455 0.40815176293908 no 1331 0.426602601304987 1977 17027303 SGTC_2686 alizarin 95.37 µM 0.184250903814293 0.408472825365823 no 1332 0.426908313760369 1931 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2261 9010538 184.68 µM 0.183311981873012 0.408859641392815 no 1333 0.427276616760041 1922 6457250 SGTC_3014 9081533 49.47 µM 0.182392424252216 0.409238565793204 no 1334 0.427637385331368 2098 21367265 SGTC_3119 9125183 49.47 µM 0.182056592107768 0.409376974146141 no 1335 0.427769156920925 2082 22695334 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.181179184317769 0.409738638327109 no 1336 0.428113466356241 2020 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_177 1327-0068 8.361 µM 0.179942656897605 0.410248460606982 no 1337 0.428598793188283 2083 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2952 9073731 13.78 µM 0.179839384318575 0.41029104693737 no 1338 0.428639331721845 1948 16457353 SGTC_3308 9128332 17.569 µM 0.179172265708415 0.410566170924547 no 1339 0.428901220036956 2091 17332805 YDL196W YDL196W SGTC_2978 9011784 42.97 µM 0.178240977391032 0.410950313770854 no 1340 0.429266864818009 2117 2994934 SGTC_101 0490-5701 117.494 µM 0.177029321248638 0.411450232064733 no 1341 0.42974267914077 2094 4661669 SGTC_2866 9034245 58.44 µM 0.176895566023875 0.411505427080779 no 1342 0.429795210749607 2128 6462273 SGTC_2431 5490079 200 µM 0.175641784330383 0.412022893753698 no 1343 0.430287686734764 1975 5722345 SGTC_2716 st080858 38.6235 µM 0.174370388821551 0.412547786337432 no 1344 0.430787192049615 2086 5296050 SGTC_3282 9108498 15.4605 µM 0.173871007781772 0.412753997442367 no 1345 0.430983418992064 1964 16459645 SGTC_2707 st078556 66.6 µM 0.171697767964707 0.413651680430018 no 1346 0.431837570330953 2127 17250899 SGTC_2580 diallyl disulphide 81.36 µM 0.171556677515494 0.413709975203161 no 1347 0.431893034359853 1978 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2364 9055074 200 µM 0.170671971169599 0.414075555335683 no 1348 0.432240851595376 1960 6470630 SGTC_3201 9113999 49.47 µM 0.168315731420632 0.415049567908861 no 1349 0.433167449266771 2051 16649224 SGTC_2914 7968218 45.32 µM 0.166666810278038 0.415731503135189 no 1350 0.43381611088668 2073 2977111 SGTC_317 4495-0002 170 µM 0.166466453182739 0.415814381051399 no 1351 0.433894940639128 1981 15991618 SGTC_659 k018-0002 107 µM 0.166464673987197 0.415815117034223 no 1352 0.433895640668765 2128 6797879 YHR007C ERG11 SGTC_97 0535-0701 19.132 µM 0.166072012509688 0.415977552775739 no 1353 0.434050139532192 2057 2832013 YGL099W LSG1 SGTC_1587 estradiol valerate 56.1 µM 0.164383990975744 0.416676014716938 no 1354 0.434714432744748 2118 13791 A steroid. SGTC_1847 st056231 15 µM 0.164092142097314 0.416796801371962 no 1355 0.434829303832183 2110 5393180 SGTC_3106 9121286 49.47 µM 0.162944858039996 0.41727170055136 no 1356 0.43528092558632 2109 15943471 SGTC_1844 rapamycin 4 nM 0.161650089775434 0.417807793326488 no 1357 0.435790705033465 2013 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1606 st000094 49.2 µM 0.161138430632778 0.418019685584595 no 1358 0.435992186231875 2142 1242210 SGTC_1141 3253-0389 52.6 µM 0.160038228860834 0.418475390216249 no 1359 0.436425480015839 2109 5402031 SGTC_2306 7482397 179.52 µM 0.159341471274871 0.418764044518661 no 1360 0.43669992438471 2104 891448 SGTC_2198 6589944 200 µM 0.158524937980802 0.419102375429918 no 1361 0.437021585722507 2075 5290268 SGTC_2682 pyrogallin 40.03 µM 0.156551046068353 0.419920505039873 no 1362 0.437799343131493 2106 822798 An ATP competetive kinase inhibitor. SGTC_910 3454-3003 490 µM 0.155998567034093 0.420149556161104 no 1363 0.438017075367455 2154 820824 SGTC_2819 7996655 46.38 µM 0.155339962966846 0.420422640769705 no 1364 0.438276656040906 2103 6456960 SGTC_2870 9038528 12.99 µM 0.154931305707168 0.420592106315184 no 1365 0.438437736620849 2041 6463316 SGTC_984 1492-0255 2.91 µM 0.154912793349589 0.420599783529287 no 1366 0.438445033885206 2046 1585198 SGTC_1024 4507-0395 26 µM 0.15469599301201 0.420689694509134 no 1367 0.43853049453994 2014 4201836 SGTC_998 3996-0085 177 µM 0.154656266250061 0.420706170356947 no 1368 0.438546154766835 2098 715391 SGTC_2450 5739737 12.93 µM 0.154099058075488 0.420937275476057 no 1369 0.438765815478342 2026 2262825 SGTC_1378 2093-0007 380 nM 0.153320429135662 0.421260261685018 no 1370 0.439072795510313 2030 3618014 SGTC_1851 st056236 18.9 µM 0.152937563216785 0.421419099289169 no 1371 0.439223756591441 2162 5393171 SGTC_3231 9132313 49.47 µM 0.15268974593322 0.421521916783437 no 1372 0.439321473750391 2049 4905967 SGTC_163 TUB2.036 7.546 µM 0.151359090023769 0.422074087069605 no 1373 0.439846229516818 2149 15992207 YJR013W GPI14 SGTC_1054 3429-0080 167 µM 0.150374174412527 0.422482887355117 no 1374 0.440234707703452 2099 1162877 SGTC_1656 st012921 11 µM 0.149885992597266 0.422685543682279 no 1375 0.44042728157816 2120 6732821 SGTC_38 0929-0051 58.268 µM 0.149637206461218 0.422788828826534 no 1376 0.440525426073203 2144 1379719 SGTC_3009 9080819 71.4286 µM 0.149304677247345 0.422926888728961 no 1377 0.440656612366413 2014 17027216 SGTC_865 0488-0499 301 µM 0.147070188694447 0.423854851242232 no 1378 0.441538309976176 2178 9634651 SGTC_593 1203-0218 61.7 µM 0.14677953042856 0.423975590097808 no 1379 0.441653021012578 2155 3666956 SGTC_3315 9136395 68.55 µM 0.146239645890078 0.424199875973403 no 1380 0.441866104537424 2168 16876844 SGTC_679 0422-0091 41.4 µM 0.145950811784361 0.424319877289672 no 1381 0.441980109508125 2043 627384 YHR062C RPP1 SGTC_887 0885-0007 9.62 µM 0.14594807301773 0.424321015193049 no 1382 0.441981190542709 2129 5719458 SGTC_1314 1222-0010 41.1 µM 0.145665399485939 0.424438463846654 no 1383 0.442092768587039 2051 3526027 SGTC_2227 7312221 64.1025 µM 0.145459626789581 0.424523965021909 no 1384 0.442173994911402 2140 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2942 9052777 62.25 µM 0.145430400678487 0.424536109131317 no 1385 0.442185531768391 2069 6469503 SGTC_1175 0741-0056 27.6 µM 0.144727184428294 0.424828332942035 no 1386 0.44246313752726 2122 765927 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.143988881870559 0.42513518143982 no 1387 0.442754624564053 2002 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_260 nsc-65238 3.989 µM 0.143770845595255 0.425225808939918 no 1388 0.442840712751534 2128 3246252 SGTC_600 1495-0418 41.6 µM 0.142510662631799 0.425749685435178 no 1389 0.443338328884639 2061 5377768 SGTC_1112 tnp00069 1.16933 µM 0.142486116921372 0.425759890750649 no 1390 0.44334802228891 2141 145826 SGTC_1258 0671-0043 57.1 µM 0.139477717176418 0.427011060934312 no 1391 0.444536331466898 2028 4298767 SGTC_502 l-744,832 89.3 µM 0.139413290485271 0.427037863576426 no 1392 0.444561785315366 2166 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1641 st009299 47.1 µM 0.13910731459336 0.427165159551436 no 1393 0.444682674108898 2172 4046054 SGTC_19 0279-0214 38.434 µM 0.138899999511851 0.427251413714771 no 1394 0.44476458567684 2148 3566274 YBR002C RER2 SGTC_2684 capsaicin 100 µM 0.138393765727418 0.427462048654644 no 1395 0.444964611918142 2105 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2945 9067681 61.76 µM 0.138277887514179 0.427510266443844 no 1396 0.445010400411347 2156 16456930 SGTC_488 nitrendipine 139 µM 0.135810249034558 0.428537325137437 no 1397 0.44598564428903 2174 4507 Dihydropyridine L-type calcium channel blocker. SGTC_3045 9092950 49.47 µM 0.134987617994366 0.428879821317528 no 1398 0.446310832066675 2176 44120432 SGTC_2319 6033012 152.6 µM 0.134578570474423 0.429050145096551 no 1399 0.446472542866509 2074 847246 SGTC_2845 9003024 42.97 µM 0.133607311066169 0.429454621819231 no 1400 0.446856551316756 2150 2990173 SGTC_3318 9139014 38.6185 µM 0.13331721827575 0.429575444074791 no 1401 0.446971255467817 2029 16643984 SGTC_1311 1190-0148 100 µM 0.132593485782438 0.429876903921109 no 1402 0.447257442261466 2159 1961333 SGTC_1230 0170-0365 3.77 µM 0.132280952127816 0.430007097748548 no 1403 0.447381036485458 2165 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_625 k213-0058 121 µM 0.13043888915993 0.430774610006357 no 1404 0.448109600150829 2092 3655420 SGTC_1937 st074714 47.2 µM 0.130190664147839 0.430878055271315 no 1405 0.448207790323468 2128 17250970 SGTC_1840 st055363 71 µM 0.129839551398089 0.431024386057998 no 1406 0.448346685134832 2010 676033 SGTC_2926 9010726 65.15 µM 0.129709788010886 0.431078469028071 no 1407 0.448398019141331 2036 2994293 SGTC_331 k048-0133 24.5 µM 0.128988428612367 0.431379141763493 no 1408 0.44868340248299 2123 6813582 SGTC_1870 st057514 26.5 µM 0.128693107790556 0.431502247115138 no 1409 0.448800244622455 2107 5393161 SGTC_2458 5808907 16.39 µM 0.128454513796023 0.431601710582009 no 1410 0.448894646332871 2191 2731747 SGTC_2646 retinol 96.75 µM 0.128137077627397 0.431734047968524 no 1411 0.449020247093689 2134 445354 A vitamin A analog and teratogen. SGTC_2010 4012422 159 µM 0.128086045898972 0.431755323529672 no 1412 0.449040439422003 2127 952393 SGTC_1411 3909-8223 150 µM 0.127396548133728 0.432042800387066 no 1413 0.449313274085617 2200 X1411 SGTC_567 1080-0542 68.4 µM 0.126471704036415 0.432428458228215 no 1414 0.449679273039593 2189 5950415 SGTC_712 r015-0009 80.6 µM 0.126352584386675 0.432478135533811 no 1415 0.449726416716732 2136 6813872 YLR060W FRS1 SGTC_728 3030-5151 22.5 µM 0.126204309067922 0.432539973324324 no 1416 0.449785100249199 2120 3125388 SGTC_2597 laccaic acid a 100 µM 0.124818448864898 0.433118021986531 no 1417 0.450333640766325 2099 5491415 A textile dye. SGTC_72 0744-0168 198.391 µM 0.123863705151421 0.433516333320851 no 1418 0.450711595342406 2062 677577 SGTC_252 miconazole 1.30953 nM 0.123347066431568 0.433731898990334 no 1419 0.450916135870926 2178 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3021 9087658 49.47 µM 0.122090552990573 0.434256256903957 no 1420 0.4514136517645 2196 25237042 SGTC_2444 5485484 36.41 µM 0.122082562553481 0.434259591778986 no 1421 0.451416815819289 2149 6790631 SGTC_1781 st038725 66.3 µM 0.120651858129244 0.434856783298052 no 1422 0.451983395989667 1999 4270275 YIL048W NEO1 SGTC_2172 5754775 163.918 µM 0.120094098591726 0.435089638514641 no 1423 0.452204303599756 2081 2263357 SGTC_169 k015-0017 16.025 µM 0.119678765499895 0.435263047716342 no 1424 0.452368811058426 2171 1840002 SGTC_523 1934-0222 13.7 µM 0.118693079633865 0.435674639464516 no 1425 0.452759259720848 2045 1361595 SGTC_15 0266-0086 27.098 µM 0.11708296835387 0.436347121529659 no 1426 0.4533971530928 2202 1712902 YIL048W NEO1 SGTC_3324 9138759 60.749 µM 0.115778361099695 0.436892141277095 no 1427 0.453914100254116 2138 45595710 SGTC_3120 9124077 49.47 µM 0.114080334898577 0.437601697137874 no 1428 0.454587055459659 2233 18774327 YGL155W CDC43 SGTC_778 3456-2434 196 µM 0.113766841502276 0.437732718944451 no 1429 0.454711312268897 2205 5539063 SGTC_951 1171-0579 82.7 µM 0.113132155890487 0.437998001100118 no 1430 0.454962890961234 2200 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2269 7935389 174.42 µM 0.110808535263788 0.438969451252039 no 1431 0.455884088437777 2184 97605 SGTC_1749 st037932 54.2 µM 0.11018150931496 0.439231659038151 no 1432 0.456132713205047 2117 594497 SGTC_2592 piperlongumine 83.33 µM 0.110121465536273 0.439256769361993 no 1433 0.456156522325807 2085 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_690 glyoxal 20.3 µM 0.109843443042035 0.439373041625863 no 1434 0.456266768456553 2137 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1322 1348-1070 12 µM 0.109691730216381 0.439436491913264 no 1435 0.456326929584781 2194 6758089 SGTC_1122 capsaicin 818.572 nM 0.109498522204144 0.439517298829551 no 1436 0.456403546916326 2134 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.108990496696703 0.439729786375418 no 1437 0.45660501398408 2229 1241132 A phosphatase inhibitor. SGTC_1673 st016611 27.3 µM 0.108473279558175 0.439946136264698 no 1438 0.456810137625769 2168 5226799 SGTC_1572 epiandrosterone 68.9 µM 0.106528884070702 0.440759629143232 no 1439 0.457581369809298 2130 441302 A steroid. SGTC_1437 4092-1038 11.6 µM 0.105608986340046 0.441144581740682 no 1440 0.457946297280192 2184 3977136 SGTC_871 0574-0004 149 µM 0.105568846024271 0.441161380658212 no 1441 0.457962221929302 2075 9551173 SGTC_2436 5633522 8.09 µM 0.103918175194719 0.441852285777996 no 1442 0.458617141739289 2233 5724242 SGTC_1573 oleylamine 1.06 µM 0.103770740396343 0.441914004756247 no 1443 0.458675643430495 2157 5356789 An amine of the fatty acid oleic acid. SGTC_2395 5646831 180.19 µM 0.103551707630037 0.442005698593125 no 1444 0.45876255663546 2172 6808628 SGTC_2370 9071495 200 µM 0.103360693594453 0.442085665466461 no 1445 0.458838353489068 2059 21791103 SGTC_136 0097-0015 404.482 µM 0.103332627701159 0.442097415282271 no 1446 0.458849490526706 2225 4861337 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.101776526227724 0.442748958228616 no 1447 0.45946702911841 2133 442882 SGTC_3096 9117468 49.47 µM 0.101607427822262 0.442819769445125 no 1448 0.459534141708816 2232 41316311 SGTC_1484 3473-2379 286 µM 0.101430890421685 0.442893697745032 no 1449 0.45960420795376 2230 671917 SGTC_3003 9075612 71.4286 µM 0.100414177460086 0.443319503712525 no 1450 0.460007757334457 2153 6501993 SGTC_874 0599-0792 117 µM 0.0998768187538557 0.443544579488764 no 1451 0.460221060133467 2232 765305 SGTC_2338 7999974 200 µM 0.0994213670239039 0.443735362322487 no 1452 0.460401859189502 2224 315925 SGTC_467 ro 31-8220 72.8 µM 0.0982942427587061 0.444207556065344 no 1453 0.460849324828981 2240 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_950 1165-0508 94.1 µM 0.0976209968304317 0.444489641334551 no 1454 0.461116625540298 2128 6148369 SGTC_1971 st069429 63.5 µM 0.0970726806629783 0.444719402702698 no 1455 0.461334338025996 2238 1246522 YGL099W LSG1 SGTC_448 monastrol 171 µM 0.0964299740524117 0.444988740216161 no 1456 0.461589543596191 2202 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_162 k030-0015 37.8 µM 0.0946813359776334 0.445721665967606 no 1457 0.462283971550902 2214 1809920 YMR134W ERG29 SGTC_1179 1021-1431 9.29 µM 0.0945210694703574 0.445788849536199 no 1458 0.462347623176987 2172 2840958 SGTC_3083 9117465 49.47 µM 0.0937110476481737 0.446128433695943 no 1459 0.462669347072942 2083 16420915 SGTC_3347 9188721 44.724 µM 0.0931920161951238 0.446346047215105 no 1460 0.462875508470592 2151 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1940 st075990 51.1 µM 0.0930085622196877 0.446422967550059 no 1461 0.462948379521587 2172 1084979 SGTC_2849 9019321 12.99 µM 0.0925980902662735 0.446595081448651 no 1462 0.463111430488883 2180 16489627 SGTC_596 1155-0152 116 µM 0.092167760358257 0.44677553273536 no 1463 0.463282376246483 2219 280313 SGTC_84 0443-0269 128.823 µM 0.0913953121115921 0.447099472958991 no 1464 0.46358924327714 2241 6150058 SGTC_1803 st050068 52.4 µM 0.0910083579131576 0.447261762524149 no 1465 0.463742974982331 2262 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_179 1273-0063 6.77 µM 0.0909829909619804 0.447272401796065 no 1466 0.463753053120624 2187 3108139 SGTC_23 0213-0011 39.996 µM 0.0907435773435627 0.447372817252063 no 1467 0.463848171867043 2237 627608 SGTC_2376 9072922 81.32 µM 0.0905548187526741 0.447451989228911 no 1468 0.463923166888331 2188 17087968 SGTC_3043 9092303 49.47 µM 0.0892150331718056 0.448014002308881 no 1469 0.464455509137772 2185 25236084 SGTC_1271 0832-2808 169 µM 0.0892003596110057 0.448020158152088 no 1470 0.464461339795137 2233 3663794 SGTC_2944 9067346 25.62 µM 0.0891748365496303 0.448030865600928 no 1471 0.464471481606971 2187 6473075 SGTC_2137 5261020 140 µM 0.0887206053791974 0.448221431239268 no 1472 0.464651978193096 2224 763655 SGTC_2985 9022375 71.43 µM 0.08647969324714 0.449161745206042 no 1473 0.465542549014822 2161 4939335 SGTC_1127 asiatic acid 681.4 nM 0.0836151563148135 0.450364154906958 no 1474 0.466681208070414 2168 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1778 st046819 58.9 µM 0.0833732749473339 0.450465707347385 no 1475 0.466777369007065 2260 671715 SGTC_1089 terbinafine 2.25 µM 0.0809392883410698 0.451487781424518 no 1476 0.467745117435069 2247 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0802085670062317 0.451794687342823 no 1477 0.468035688315741 2213 115019 SGTC_3199 9111318 49.47 µM 0.080016682200508 0.451875284521656 no 1478 0.468111994018041 2232 8548020 SGTC_787 4152-0075 138 µM 0.0797445959335498 0.451989572037798 no 1479 0.468220194971613 2121 9566539 SGTC_2136 5328288 199.296 µM 0.0791081255848575 0.452256931502892 no 1480 0.468473310244397 2198 262395 SGTC_1248 0469-0687 58.6 µM 0.0787843810280946 0.452392933853883 no 1481 0.468602063780853 2203 4017482 SGTC_1817 st052116 64.4 µM 0.0787694032929126 0.45239922600911 no 1482 0.468608020520812 2248 4361398 SGTC_2145 5634607 200 µM 0.0756078114832167 0.453727677699755 no 1483 0.46986556079573 2219 308662 SGTC_400 oxethazaine 37.5 µM 0.0741915949515051 0.454322918698022 no 1484 0.470428966838746 2172 4621 A local anesthetic. SGTC_2181 6316240 54.2555 µM 0.0737365801365123 0.454514184933691 no 1485 0.470609995631379 2186 12779990 SGTC_632 0781-2353 4.65 µM 0.0732558268158537 0.454716281851165 no 1486 0.470801271151615 2216 6811515 YHR007C ERG11 SGTC_365 0121-0052 13.6 µM 0.0728508033442919 0.454886552895506 no 1487 0.470962421550979 2248 3101739 SGTC_1352 1496-0991 99 µM 0.0727401686857637 0.45493306492377 no 1488 0.471006441604113 2245 3000039 SGTC_2242 6630449 61.2675 µM 0.0726353457209047 0.454977134222073 no 1489 0.47104814958879 2201 691249 YDR170C SEC7 SGTC_2264 7948757 110.76 µM 0.0698247046382288 0.456158978845977 no 1490 0.472166591853026 2284 2971411 SGTC_1755 st041960 45.185 µM 0.0693819525292589 0.456345187029843 no 1491 0.47234279704633 2222 2257073 SGTC_3101 9120531 49.47 µM 0.0687415005934182 0.456614558752827 no 1492 0.472597691809276 2286 24824904 SGTC_1197 1601-0112 267 µM 0.0687002639352591 0.456631903423753 no 1493 0.472614104056019 2268 7350313 SGTC_79 0052-0007 94.094 µM 0.0686158819970655 0.456667395814107 no 1494 0.472647688328527 2276 2801472 SGTC_2529 gangaleoidin 93.61 µM 0.0684268127597333 0.456746922608456 no 1495 0.472722939175638 2254 4565183 SGTC_1838 st055369 84.5 µM 0.0665854543175056 0.457521529698908 no 1496 0.473455862908955 2287 676036 SGTC_1071 trifluoperazine 6.31 µM 0.0641507413400331 0.458545991462709 no 1497 0.474425099635207 2252 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2152 5568786 200 µM 0.0640485039955855 0.458589016261246 no 1498 0.474465802728918 2292 5399883 SGTC_119 0121-0043 24.815 µM 0.0637728769710298 0.458705011490102 no 1499 0.474575537662925 2280 1092378 SGTC_3089 9117425 49.47 µM 0.0625313908175939 0.459227523553957 no 1500 0.475069832294018 2144 9401657 SGTC_896 0964-0007 44.5 µM 0.0615744891851077 0.459630308864135 no 1501 0.475450846531789 2307 6756758 SGTC_2920 7982904 15.77 µM 0.0602483038417546 0.460188603919725 no 1502 0.47597893732826 2255 6456808 SGTC_1762 st045503 25.4615 µM 0.0595705537461994 0.460473952281377 no 1503 0.476248835705421 2243 4645554 SGTC_2788 5282734 71.43 µM 0.0582305867669849 0.461038168933145 no 1504 0.476782478666921 2273 743706 SGTC_2093 5331342 194.4 µM 0.055997733664656 0.461978524684679 no 1505 0.477671806301873 2307 33839 SGTC_1739 st037196 92.5 µM 0.0555941640117893 0.462148509012378 no 1506 0.477832556880171 2299 612214 SGTC_2384 9036245 200 µM 0.0537771603627696 0.462913919697354 no 1507 0.478556353286043 2269 6462766 SGTC_1754 st042065 16.137 µM 0.0537769761950066 0.462913997284819 no 1508 0.478556426652187 2248 1126236 YIL048W NEO1 SGTC_1512 0259-0544 12.2 µM 0.0534145052339962 0.463066704281009 no 1509 0.478700824103073 2210 18476 SGTC_1021 4476-0760 85.3 µM 0.0532321868755518 0.463143516048268 no 1510 0.478773455272234 2277 746768 SGTC_46 0329-0187a 2.197 µM 0.0532256736274267 0.463146260142397 no 1511 0.478776050003838 2254 46494817 SGTC_1023 4482-3888 16 µM 0.052744491628566 0.463348991591822 no 1512 0.478967744573472 2306 3303168 SGTC_606 k015-0008 38.6 µM 0.0526779583970758 0.463377024102382 no 1513 0.478994250643767 2299 1970475 SGTC_1941 st076221 61.8 µM 0.0499371237580034 0.464531979036281 no 1514 0.480086246856956 2323 2828568 SGTC_920 mycophenolic acid 780.421 nM 0.0488500809347645 0.464990129206501 no 1515 0.480519385485842 2277 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3076 9116187 49.47 µM 0.0480123286741863 0.465343243907248 no 1516 0.480853208539066 2304 27241210 SGTC_1391 3442-0225 151 µM 0.0473491522773663 0.465622793805788 no 1517 0.481117477066444 2300 5227075 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.0468089283400197 0.4658505278853 no 1518 0.4813327565245 2318 1377 SGTC_2789 5281112 71.43 µM 0.0466952923287244 0.465898433135426 no 1519 0.481378041216175 2281 765948 SGTC_2407 paclitaxel 400 µM 0.0462227589988268 0.466097643125613 no 1520 0.481566351400698 2221 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2756 carbadox 75.1 µM 0.0449706545977436 0.466625544623979 no 1521 0.482065349759815 2297 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_234 nsc-17383 10.7 µM 0.0436452794677218 0.467184401851597 no 1522 0.482593579134499 2322 408974 SGTC_635 k038-0028 24.7 µM 0.0428076336159869 0.467537636751451 no 1523 0.482927439411862 2286 4035102 SGTC_540 1187-0821 17.3 µM 0.0425832838862173 0.467632249289144 no 1524 0.483016860464406 2307 847520 SGTC_2211 7117706 200 µM 0.0420295691870831 0.4678657690982 no 1525 0.483237563067468 2334 822771 SGTC_2957 9076800 11.52 µM 0.041271583297178 0.468185454741531 no 1526 0.483539693502501 2301 16459615 SGTC_3292 9120825 59.784 µM 0.0400818783410885 0.468687262098324 no 1527 0.48401392458988 2342 24824900 SGTC_2511 berberine 10.47 µM 0.0396463697388467 0.468870968376686 no 1528 0.484187529386713 2323 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3151 9099821 49.47 µM 0.0393692798342626 0.468987853917984 no 1529 0.484297986026995 2293 17174189 SGTC_3044 9093193 49.47 µM 0.0389603877496498 0.469160342788745 no 1530 0.484460985307572 2292 25236277 SGTC_2840 9008771 71.43 µM 0.0386760289866056 0.469280301379034 no 1531 0.484574342601983 2331 2992978 SGTC_1906 st060206 94.7 µM 0.0385342581210544 0.469340109381472 no 1532 0.484630858863931 2327 5133468 SGTC_1475 4092-1048 11.7 µM 0.0384779103547372 0.469363880659023 no 1533 0.484653321711104 2245 2881759 SGTC_2864 9034755 47.6 µM 0.0383494428732294 0.469418077291081 no 1534 0.484704535021706 2347 4930451 SGTC_1917 st066507 28.5 µM 0.0365967436014809 0.470157545470804 no 1535 0.485403270011128 2271 3156428 SGTC_758 0868-0029 16 µM 0.0358912852188734 0.470455209310769 no 1536 0.485684522389924 2347 762687 SGTC_1334 1486-0610 236 µM 0.0356190603138699 0.470570077364218 no 1537 0.485793055015984 2286 3742339 SGTC_2967 9089538 49.85 µM 0.0338966486560751 0.471296922764786 no 1538 0.486479782819554 2349 728216 SGTC_2517 totarol 10 µM 0.0328837646330213 0.471724397381827 no 1539 0.486883639870174 2286 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1885 st057546 99.9 µM 0.032850956877356 0.471738244018596 no 1540 0.486896721203482 2341 702008 SGTC_227 fluconazole 33.516 µM 0.0323388069675304 0.471954403234234 no 1541 0.487100930946463 2321 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1373 2887-0003 58.5 µM 0.0321286909807564 0.472043087683536 no 1542 0.487184711561274 2315 776948 SGTC_102 gallobenzophenone 83.616 µM 0.0314261154766679 0.47233963642533 no 1543 0.487464857147579 2356 70837 SGTC_487 nimodipine 119 µM 0.0306374004261416 0.472672561903364 no 1544 0.487779357456633 2359 4497 L-type voltage-gated calcium channels inhibitor SGTC_451 chloral hydrate 100 µM 0.0303115043081691 0.472810131901268 no 1545 0.487909310839174 2329 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2872 9044037 25.97 µM 0.0287016290945391 0.473489753172742 no 1546 0.488551278537362 2306 6465195 SGTC_936 3005-4620 401 µM 0.0278637611498603 0.473843496264085 no 1547 0.488885405813375 2360 777207 SGTC_1201 1889-3372 45.9 µM 0.027393885580278 0.474041884107592 no 1548 0.48907278751015 2290 5392199 SGTC_1446 4239-0190 62 µM 0.0263699168540598 0.474474239837036 no 1549 0.489481144337557 2342 1340085 SGTC_2585 alliin 100 µM 0.0259610090851175 0.474646903554987 no 1550 0.489644219101625 2340 87310 A garlic compound which reacts with lipids. SGTC_1003 4049-0218 100 µM 0.0256930551876445 0.47476005125382 no 1551 0.489751081593719 2338 295161 SGTC_3345 9148410 3.559 µM 0.0255520927244772 0.474819575663055 no 1552 0.489807299023321 2354 4903596 SGTC_1000 4048-0884 8.67 µM 0.0252383808557102 0.474952049211963 no 1553 0.489932411600938 2330 13040088 SGTC_10 0279-0212 42.575 µM 0.0250810636176263 0.475018481828174 no 1554 0.489995152237662 2364 39851 YBR002C RER2 SGTC_1769 st044406 64.4 µM 0.0249172008326119 0.475087679265243 no 1555 0.49006050360664 2345 670903 SGTC_1146 3579-1023 7 µM 0.0246109681688376 0.475216999936232 no 1556 0.490182635308404 2352 X1146 SGTC_1914 st062367 72.6 µM 0.0241883229014439 0.475395485409588 no 1557 0.49035119619071 2348 978205 SGTC_1063 disulfiram 1.84 µM 0.0229953964773994 0.475899291466565 no 1558 0.490826972529233 2369 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3198 9112019 49.47 µM 0.0216824400244424 0.47645383406014 no 1559 0.491350635655647 2361 45595555 SGTC_2611 pyromycin 23.93 µM 0.0215344470211992 0.476516343524772 no 1560 0.491409662539623 2354 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2770 toltrazuril 17.5 µM 0.0215294980054576 0.476518433906052 no 1561 0.491411636453617 2358 68591 Kills coccidiodes. SGTC_2372 9071633 200 µM 0.0210066450216341 0.476739281869973 no 1562 0.491620177442826 2373 21321366 SGTC_1698 5-fluorocytosine 1.055 µM 0.0202535083284615 0.477057411950993 no 1563 0.491920571574874 2368 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2806 7952793 58.44 µM 0.0200741723119558 0.477133166871746 no 1564 0.491992101751297 2355 2972490 SGTC_1707 st032323 6.317 µM 0.0197233580840192 0.477281359814776 no 1565 0.492132028673135 2368 3132057 YMR211W DML1 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.0197041730510567 0.477289464156393 no 1566 0.492139680906837 2334 5282362 SGTC_1905 st060207 84.5 µM 0.0177135069634809 0.478130432503164 no 1567 0.492933702670065 2353 1948547 SGTC_3348 9149464 3.537 µM 0.0175184548154817 0.478212838704882 no 1568 0.493011505145785 2380 1951442 SGTC_3242 9133940 49.47 µM 0.0174252810728794 0.478252203349013 no 1569 0.493048670418036 2370 17248444 SGTC_346 4513-0042 7.16 µM 0.0172249802150993 0.478336828465984 no 1570 0.4931285669071 2373 2827372 SGTC_2252 omeprazole 400 µM 0.0167062965161924 0.478555971691429 no 1571 0.493335461984684 2347 4594 A proton pump inhibitor. SGTC_387 norethindrone acetate 66.7 µM 0.0165000862767272 0.478643097069025 no 1572 0.493417716629529 2359 541197 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0158376109144685 0.478923004778944 no 1573 0.493681971511872 2371 641818 YHR062C RPP1 SGTC_693 4161-2696 114 µM 0.0152713263581568 0.479162278396135 no 1574 0.49390785903367 2373 805759 SGTC_1108 betulinic acid 729.144 nM 0.0152660029289266 0.479164527753647 no 1575 0.493909982527125 2376 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1622 st003707 19.4 µM 0.0149224644575782 0.479309687623425 no 1576 0.494047018935821 2326 10140899 SGTC_3145 9085516 49.47 µM 0.0139233097596907 0.47973188924687 no 1577 0.494445582516204 2341 25236195 SGTC_1386 3228-0095 33.8 µM 0.0131780142020902 0.480046835287314 no 1578 0.494742885121975 2370 870181 SGTC_3306 9127676 59.7925 µM 0.011946486440422 0.480567279913129 no 1579 0.495234154819353 2369 41905287 SGTC_138 0850-0259 40.9225 µM 0.011620337123481 0.480705116462213 no 1580 0.495364260538203 2387 6813004 SGTC_2246 7293507 91.5585 µM 0.0115979003581505 0.480714598726523 no 1581 0.49537321090938 2373 887656 SGTC_1567 st069303 68.4 µM 0.0114441310144434 0.48077958528411 no 1582 0.495434551930806 2370 5581319 SGTC_2515 chrysin 20.77 µM 0.0114223512535395 0.480788789966974 no 1583 0.495443240230406 2386 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2469 5655019 90.81 µM 0.0113689783558858 0.480811346759107 no 1584 0.495464531553402 2385 2788239 SGTC_1316 1272-0050 65.9 µM 0.0112176384777206 0.480875307311042 no 1585 0.495524903579444 2389 7340392 SGTC_1358 1509-0022 2.48 µM 0.00972259327644585 0.481507182277579 no 1586 0.496121307575012 2376 3258434 SGTC_2649 anisomycin 9.56 µM 0.00958641386098371 0.481564740303891 no 1587 0.496175632769648 2375 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_849 0386-0493 241 µM 0.00958456751569912 0.481565520688724 no 1588 0.496176369321008 2379 726119 SGTC_2749 bexarotene 57.39 µM 0.00941827431614559 0.481635807230508 no 1589 0.496242707714694 2377 82146 An retinoic acid receptor inhibitor. SGTC_2969 9091408 28.7 µM 0.00685170043390299 0.482720682741045 no 1590 0.49726658839132 2384 4286311 SGTC_556 4058-0063 51.5 µM 0.00674889644889216 0.482764140092657 no 1591 0.497307600299227 2388 6615692 SGTC_2204 7233102 200 µM 0.00656517761383627 0.48284180231951 no 1592 0.497380891886116 2393 2172480 SGTC_877 0771-0151 33.1 µM 0.00569356207793749 0.483210263310946 no 1593 0.497728609632838 2364 6166523 SGTC_1527 coumarin 137 µM 0.00564220769778871 0.483231972972626 no 1594 0.497749096737285 2389 323 A hepatotoxic, DNA x-linker. SGTC_783 0848-0141 92.7 µM 0.00436201118889271 0.483773181913375 no 1595 0.498259814827627 2395 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1763 st044482 94.5 µM 0.00357140930454262 0.48410742747982 no 1596 0.498575216856643 2396 88505 SGTC_2447 5741742 33.78 µM 0.00355960728641809 0.484112417146123 no 1597 0.498579925150738 2397 1776504 SGTC_1974 st069448 26.9 µM 0.00229859598710324 0.484645562649259 no 1598 0.499082993682691 2397 6323587 YNR016C ACC1 SGTC_1496 4469-0713 57.4 µM 0.00214250438645481 0.484711558859622 no 1599 0.499145265068216 2399 746691 SGTC_2383 9036125 200 µM 0.00209527562553534 0.484731527468586 no 1600 0.4991641065755 2399 79580 SGTC_2628 lathosterol 100 µM 0.00199294226584533 0.484774794770228 no 1601 0.499204931594067 2399 6710616 SGTC_369 0957-0393 4.5 µM 0.00156918583352224 0.484953964027601 no 1602 0.499373985682111 2401 6997992 SGTC_2385 9074692 200 µM -0.000382201080451963 0.485779072256195 no 1603 0.499847523833105 2406 17046906 SGTC_98 0074-0023 107.663 µM -0.000803210507121168 0.485957096490331 no 1604 0.499679565403101 2410 3563821 SGTC_922 1866-0035 480 µM -0.0014095369488685 0.486213487108118 no 1605 0.499437676301512 2410 3156169 SGTC_3047 9092122 49.47 µM -0.00151071232263223 0.486256270587342 no 1606 0.499397313210226 2406 17173831 SGTC_753 1322-0200 289 µM -0.00207590274854317 0.486495272480555 no 1607 0.499171835218416 2413 5403907 SGTC_831 k061-1017 217 µM -0.00321473489289332 0.486976864708306 no 1608 0.498717508539933 2416 1240153 SGTC_813 k007-0158 173 µM -0.00435300508197362 0.48745823827346 no 1609 0.498263407710348 2421 6523916 SGTC_2324 6149169 200 µM -0.00482134217793304 0.487656303007698 no 1610 0.498076570208739 2414 2888231 SGTC_1953 st076800 12.1 µM -0.00499974991930009 0.487731754340657 no 1611 0.498005396675777 2425 297591 SGTC_3033 9090887 49.47 µM -0.00500927482332974 0.487735782579045 no 1612 0.498001596836427 2407 19325384 SGTC_2439 5492030 7.2 µM -0.00577086476149085 0.488057875489816 no 1613 0.497697770830647 2418 5722370 SGTC_3353 9151644 39.2805 µM -0.00639131520238359 0.488320283211864 no 1614 0.497450251497483 2424 4909158 SGTC_2653 dihydrofissinolide 100 µM -0.00849597408233627 0.489210445676246 no 1615 0.496610637500331 2429 6857746 SGTC_818 4072-2707 53.5 µM -0.00856737510800742 0.48924064560564 no 1616 0.496582153649014 2420 882871 SGTC_3098 9119039 49.47 µM -0.00878272467893885 0.489331730690213 no 1617 0.496496244832928 2413 17161528 SGTC_2328 6201408 200 µM -0.00898655474262271 0.489417943952218 no 1618 0.496414931612015 2437 2890418 SGTC_655 k060-0012 42 µM -0.00974146563492474 0.48973725014653 no 1619 0.496113778949819 2421 5994525 SGTC_44 0929-0055 61.211 µM -0.0102814776917788 0.48996566419097 no 1620 0.49589835610717 2407 1379590 SGTC_2506 ethyl hematommate 54.16 µM -0.0105246728336708 0.490068531836289 no 1621 0.495801340532768 2439 3940691 An allergen. SGTC_2576 guaiol 23.12 µM -0.0112306126709602 0.490367136784825 no 1622 0.495519727951232 2441 227829 SGTC_1730 st033808 45.1 µM -0.0127882179854987 0.491026005918182 no 1623 0.494898378206919 2451 1045166 SGTC_3040 9091894 49.47 µM -0.0136698027953851 0.491398928439796 no 1624 0.494546707537594 2439 25236966 SGTC_1810 st050138 53 µM -0.0138697423733505 0.491483506693752 no 1625 0.494466950748117 2426 3444541 SGTC_2505 galangin 7.89 µM -0.0139805961944948 0.491530400139118 no 1626 0.494422730759506 2432 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2312 7706453 155.7 µM -0.014013726944384 0.491544415150199 no 1627 0.494409514797297 2438 976098 SGTC_3079 9117512 49.47 µM -0.0140542132222102 0.49156154172004 no 1628 0.494393364699775 2430 7185044 SGTC_2835 9006588 71.43 µM -0.0144237739678271 0.491717874611417 no 1629 0.494245946239236 2478 2345538 SGTC_3220 9131269 49.47 µM -0.0161058168302208 0.492429434034966 no 1630 0.493574986479123 2436 17722206 SGTC_1672 st016598 6.51 µM -0.016111508828805 0.492431841979652 no 1631 0.49357271599483 2464 4665860 YNL267W PIK1 SGTC_3180 9109287 49.47 µM -0.0168608705951247 0.492748854567403 no 1632 0.49327380453392 2450 18891271 SGTC_1030 k029-0042 36.7 µM -0.0168949558423939 0.492763274218448 no 1633 0.493260208424306 2456 6080581 SGTC_3300 9124615 50.48 µM -0.0169972818553576 0.492806562956295 no 1634 0.493219392112418 2457 24824903 SGTC_2317 5986382 200 µM -0.0170797159788743 0.492841436546756 no 1635 0.493186510428503 2445 877883 SGTC_889 0919-1524 82.7 µM -0.0176882663886983 0.493098884251214 no 1636 0.492943770625151 2463 3905452 SGTC_508 roscovitine 141 µM -0.0178095868087302 0.493150209292413 no 1637 0.49289537840312 2429 160355 A CDKinase inhibitor. SGTC_578 3460-0051 92 µM -0.0188060111656443 0.493571754422953 no 1638 0.49249792922756 2442 2876744 SGTC_465 cgp-37157 41 µM -0.0200556949088663 0.494100453012036 no 1639 0.491999471684898 2440 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1660 st012960 28.1 µM -0.0207111114234114 0.494377741597311 no 1640 0.491738052643893 2470 24207266 SGTC_702 1488-0190 94 µM -0.0212016271717372 0.494585267017538 no 1641 0.491542408139902 2446 949357 SGTC_752 1896-0090 130 µM -0.0214222717368571 0.494678616909541 no 1642 0.491454403682159 2449 772567 SGTC_1523 st012844 44.7 µM -0.0225471348924275 0.495154526341097 no 1643 0.491005756668134 2515 4274103 SGTC_841 0251-0215 91.2 µM -0.0229113949301671 0.495308639742531 no 1644 0.490860475471218 2487 3888614 SGTC_298 1391-0729 10 µM -0.0229588704815936 0.495328726046058 no 1645 0.490841540447229 2445 3237558 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.0229883578600256 0.495341201787757 no 1646 0.490829779789205 2453 5024745 SGTC_3029 9088683 49.47 µM -0.0235483130135322 0.495578112673735 no 1647 0.490606450471413 2481 25236615 SGTC_2755 lomerizine 42.69 µM -0.0235530642838139 0.495580122890888 no 1648 0.49060455551439 2463 3949 A calcium channel blocker. SGTC_799 1310-0557 151 µM -0.0243342394400986 0.49591063213935 no 1649 0.490293001043719 2525 5354492 SGTC_3277 9138724 49.47 µM -0.0248060423764441 0.496110249736101 no 1650 0.490104835711647 2472 15943418 SGTC_1355 1499-0035 1.68 µM -0.0248866889792991 0.496144371032187 no 1651 0.490072672301449 2453 1548538 SGTC_3228 9131799 49.47 µM -0.0249061363373389 0.496152599145702 no 1652 0.490064916332153 2468 17015818 SGTC_2129 girgensonine 121.053 µM -0.025131808086228 0.496248080242594 no 1653 0.489974914502905 2482 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_558 k064-0027 21.3 µM -0.0260136661821716 0.496621193990072 no 1654 0.489623219051552 2479 5088526 SGTC_1106 tegaserod maleate 11.7 µM -0.0260880358982657 0.496652659921822 no 1655 0.489593559893182 2476 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3022 9087993 49.47 µM -0.026589209804377 0.496864707841486 no 1656 0.489393689773571 2450 17173644 SGTC_2329 6138490 200 µM -0.0273974119337669 0.497206662002337 no 1657 0.48907138122647 2584 720019 SGTC_1285 0929-0069 65.5 µM -0.0275650210124086 0.49727757846511 no 1658 0.489004540123042 2480 1206237 SGTC_2314 7727897 200 µM -0.0279139026328501 0.497425192761774 no 1659 0.488865410033551 2455 900724 SGTC_3174 9107204 49.47 µM -0.0281766412566095 0.497536359577254 no 1660 0.488760633701489 2469 3938802 SGTC_2762 leflunomide 42.06 µM -0.0282912179740079 0.497584837964219 no 1661 0.488714942419736 2461 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2980 9014342 25.29 µM -0.028374783014863 0.497620195068708 no 1662 0.488681618170139 2563 2996599 SGTC_1448 4255-0083 152 µM -0.0285243982914115 0.497683498655933 no 1663 0.488621954460754 2469 5399660 SGTC_124 0136-0217 7.121 µM -0.0286540794019313 0.497738367963062 no 1664 0.48857024032129 2474 3976905 SGTC_1761 st044296 37 µM -0.0289046595846942 0.497844390933968 no 1665 0.488470314682397 2456 1826700 SGTC_1336 1486-0901 104 µM -0.0289718377956182 0.497872814730242 no 1666 0.488443525672947 2529 5006114 SGTC_830 4076-0286 57.8 µM -0.0291923783623053 0.497966127801539 no 1667 0.488355579915293 2475 6866659 SGTC_3236 9132701 49.47 µM -0.0299690838121947 0.498294761032064 no 1668 0.488045854817117 2466 24282524 SGTC_2057 5236571 38.335 µM -0.0303869940109357 0.498471584255889 no 1669 0.487879208671412 2469 54684039 YBR257W POP4 SGTC_463 ikarugamyin 104 µM -0.0304021741060327 0.498478007156816 no 1670 0.487873155486362 2463 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1264 0783-0040 158 µM -0.0305998319764779 0.498561638876411 no 1671 0.487794338075803 2456 2855798 SGTC_2156 5649887 115 µM -0.0314592520029578 0.498925271806115 no 1672 0.487451644119311 2499 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2243 6634756 200 µM -0.0322462216515263 0.499258250733245 no 1673 0.487137847889915 2473 885676 SGTC_781 4335-2806 94.4 µM -0.0332243621814014 0.499672117686111 no 1674 0.486747835316513 2570 845254 SGTC_401 neomycin 50 µM -0.0337501407557645 0.499894583211455 no 1675 0.486538197591897 2492 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2875 9039966 71.43 µM -0.0339992844397711 0.5 no 1676 0.48643886065344 2552 6463691 SGTC_1163 k060-0048 49.9 µM -0.0345696182388952 0.499758682405396 no 1677 0.486211464073041 2456 6809982 SGTC_3156 9099931 49.47 µM -0.0345791013504635 0.499754669945692 no 1678 0.486207683119412 2472 18111053 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0346544866351422 0.499722773198913 no 1679 0.486177626756044 2488 23847180 SGTC_592 k241-0073 46.5 µM -0.0351390401274149 0.499517750743179 no 1680 0.485984435551157 2472 4230158 SGTC_696 1560-0013 611 µM -0.0351591324689886 0.499509249349371 no 1681 0.485976424816584 2505 1650269 SGTC_3203 9113543 49.47 µM -0.0352365177567383 0.499476506388017 no 1682 0.485945571671127 2556 17018012 SGTC_2798 7813637 45.45 µM -0.0353087287942939 0.499445952738416 no 1683 0.485916781550441 2501 956368 SGTC_1618 st003135 44.5 µM -0.0354175512782844 0.499399908204093 no 1684 0.485873394797712 2460 1270615 SGTC_1691 st019933 84.6 µM -0.0357937957454099 0.499240713214967 no 1685 0.48572339008832 2463 6176082 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.0369412501157441 0.498755207962905 no 1686 0.485265924671423 2500 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.0369450057213577 0.498753618912156 no 1687 0.485264427423622 2519 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3115 9123671 49.47 µM -0.0375603478600135 0.498493259088806 no 1688 0.485019111710441 2464 3286988 SGTC_2427 5545055 42.75 µM -0.0379935819523478 0.49830995209289 no 1689 0.484846399597674 2477 5372858 SGTC_315 k915-0449 187 µM -0.0380796422725577 0.498273538890019 no 1690 0.484812091324595 2501 20970215 YNL149C PGA2 SGTC_275 trichlorophene 5.69 µM -0.0387102323873629 0.498006728747102 no 1691 0.484560707629966 2532 62616 SGTC_3170 9103054 49.47 µM -0.0416789214235649 0.496750655231026 no 1692 0.483377328812252 2515 16432970 SGTC_504 lovastatin 124 µM -0.0445156753600892 0.495550434321002 no 1693 0.48224667861626 2489 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2231 micatex 6.853 µM -0.0445689202059386 0.495527906959526 no 1694 0.482225458057452 2513 20737 An antifungal of unknown mechanism. SGTC_1605 st000082 49.1 µM -0.0447221125858961 0.495463092876302 no 1695 0.482164404017573 2604 1114022 SGTC_2298 7976326 193.81 µM -0.0466634542561477 0.494641742605069 no 1696 0.481390728938874 2525 2235818 SGTC_2688 kanamycin b 96.69 µM -0.0473228504732665 0.494362767720855 no 1697 0.481127958219025 2508 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3093 9117344 49.47 µM -0.0474378492187719 0.494314114760397 no 1698 0.481082131823935 2618 24824913 SGTC_210 3551-0445 56.827 µM -0.0475121542947273 0.494282678271773 no 1699 0.481052521774991 2560 2865180 YOR207C RET1 SGTC_2393 9031399 185.94 µM -0.0476578127629933 0.494221054176064 no 1700 0.480994478205683 2520 1526623 YDL150W RPC53 SGTC_2541 muurolladie-3-one 83.07 µM -0.0476839091644015 0.494210013520196 no 1701 0.480984079070585 2633 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1371 2421-0008 32.7 µM -0.0477061948401078 0.494200585079056 no 1702 0.48097519847891 2537 2827552 SGTC_69 0096-0274 206.684 µM -0.0482469070471253 0.493971825992776 no 1703 0.480759733636412 2744 6741392 SGTC_1880 MG-132 525 µM -0.0484788051415621 0.493873717480623 no 1704 0.480667327812252 2527 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1666 st014829 29 µM -0.0490487978026288 0.493632573783331 no 1705 0.48044020384389 2482 3858230 SGTC_1591 genipin 88.4 µM -0.0494322750594317 0.493470339448342 no 1706 0.480287403907533 2621 442424 A DNA cross-linking agent. SGTC_2411 st077133 39.94 µM -0.0517317299075595 0.49249755299339 no 1707 0.479371227135312 2749 1403142 YNL221C POP1 SGTC_1128 3448-9350 235 µM -0.052403860113751 0.492213215870362 no 1708 0.479103449209666 2586 619386 SGTC_2724 maprotiline 69.64 µM -0.0530189133623062 0.491953027975404 no 1709 0.478858419111415 2481 4011 A tricyclic antidepressant. SGTC_142 0335-0849 62.6745 µM -0.0532225845213216 0.491866869078618 no 1710 0.478777280634566 2515 3889043 YPR107C YTH1 SGTC_2081 5214970 32.255 µM -0.0536949772003722 0.491667034534603 no 1711 0.478589092322064 2497 2063512 SGTC_1657 st012939 43.4 µM -0.0540590624887684 0.491513018293699 no 1712 0.478444053964316 2547 24207257 SGTC_2761 levamisole 97.89 µM -0.0541776929102584 0.491462835237539 no 1713 0.478396796527927 2521 26879 An alkaline phosphatase inhibitor. SGTC_2717 st081029 62.2815 µM -0.054344445822241 0.491392295627906 no 1714 0.47833036960224 2498 5292846 SGTC_2109 5483026 200 µM -0.0548550921974956 0.491176284316545 no 1715 0.478126954604871 2534 759335 SGTC_3050 9093513 49.47 µM -0.0555356289075122 0.490888410800336 no 1716 0.477855872986609 2521 25236664 SGTC_350 k064-0020 19.8 µM -0.0566121631049707 0.490433036322901 no 1717 0.477427072664341 2530 2790705 SGTC_480 am 92016 50 µM -0.0597222043271129 0.489117559551749 no 1718 0.476188443401075 2576 2129 K+ channel blocker. SGTC_1667 st014849 34.6 µM -0.0601651888866961 0.48893019644691 no 1719 0.476012035355832 2504 5348460 SGTC_1461 k072-0203 53.8 µM -0.0607786470215031 0.488670734514228 no 1720 0.475767748042398 2490 5418714 SGTC_1367 1812-0510 76.9 µM -0.0613995426015255 0.488408131798961 no 1721 0.475520508312648 2543 1142582 YDR527W RBA50 SGTC_1486 3970-0793 4.53 µM -0.0614284641206271 0.488395899800246 no 1722 0.475508992034214 2592 2844330 SGTC_2468 5987765 72.9 µM -0.0623915116243504 0.487988597076221 no 1723 0.475125527267169 2582 26772094 SGTC_2409 alverine citrate 63.97 µM -0.062616385809223 0.48789349258208 no 1724 0.475035990516737 2799 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1067 clotrimazole 1.36 µM -0.0641460013705322 0.487246601326318 no 1725 0.474426986722756 2534 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1430 4049-0248 69.1 µM -0.0647511897474543 0.486990669670392 no 1726 0.474186052390224 2546 22774488 SGTC_1157 4092-0394 27.6 µM -0.0664178804203339 0.486285861107642 no 1727 0.473522567558637 2662 3659885 SGTC_457 grayanotoxin iii 135 µM -0.0676456677637378 0.485766682843516 no 1728 0.473033850507006 2582 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_974 1326-0144 138 µM -0.0678990852689339 0.485659526495215 no 1729 0.472932983462016 2545 5411856 SGTC_3124 9127567 49.47 µM -0.0693892982525842 0.48502941845175 no 1730 0.472339873572527 2539 17592030 SGTC_1388 3346-4487 254 µM -0.0695028286444568 0.484981415810545 no 1731 0.472294690583851 2579 3345614 SGTC_1950 st077106 7.18 µM -0.0696749491749269 0.484908640646305 no 1732 0.47222619048771 2596 13831864 SGTC_511 blebbistatin 171 µM -0.0706964307582446 0.484476753204992 no 1733 0.47181968078686 2659 3476986 A myosin inhibitor. SGTC_771 0250-0039 27.3 µM -0.0709045171295617 0.484388775479189 no 1734 0.471736874138558 2529 3005115 SGTC_333 3486-0131 40.1 µM -0.0723061725975524 0.483796183590391 no 1735 0.471179126267207 2661 6744690 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0731279905485754 0.483448751962969 no 1736 0.470852134023332 2530 77254 SGTC_2743 auranofin 4.32 µM -0.0748035101609709 0.482740448767785 no 1737 0.47018552447023 2565 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2642 cholecalciferol 100 µM -0.0748134253904885 0.482736257398883 no 1738 0.470181579918872 2545 9821465 A vitamin D precursor, similar to steriods. SGTC_1473 k844-0725 134 µM -0.074895716910432 0.482701471175678 no 1739 0.470148842198964 2536 54682906 SGTC_2247 cerulenin 830 nM -0.0752288114895816 0.482560666977964 no 1740 0.470016330523061 2727 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1282 0886-0010 32.4 µM -0.0770479120146827 0.481791744065732 no 1741 0.469292714971242 2560 2836211 YNL267W PIK1 SGTC_2910 7948405 25.97 µM -0.0773511018328239 0.481663594050789 no 1742 0.469172119630095 2578 2971328 SGTC_2037 5169046 200 µM -0.0774618518088467 0.481616783547264 no 1743 0.469128068950618 2620 5718022 SGTC_86 0417-1630 471.922 µM -0.0787653488342284 0.481065855902666 no 1744 0.468609633005868 2529 3634867 SGTC_3006 9075424 71.4286 µM -0.0792921180070636 0.48084322524221 no 1745 0.468400137741359 2559 7465181 SGTC_3197 9113331 49.47 µM -0.0795052983633298 0.480753129630276 no 1746 0.468315358735651 2625 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1206 3978-0017 132 µM -0.0799750056641465 0.480554622476904 no 1747 0.468128567436138 2797 3873677 SGTC_3136 9095672 49.47 µM -0.0803227152035982 0.480407676978864 no 1748 0.467990296230283 2513 17217380 SGTC_3092 9117248 49.47 µM -0.0804411402313021 0.480357629995069 no 1749 0.467943203863595 2537 17141857 SGTC_319 1348-1596 45.5 µM -0.0808924516968131 0.4801669064537 no 1750 0.467763741483484 2673 5380505 SGTC_3235 9132602 49.47 µM -0.080954401159588 0.480140727058023 no 1751 0.467739108013116 2626 4912240 SGTC_934 2950-0684 338 µM -0.080995210134793 0.480123481526546 no 1752 0.467722880874807 2701 1121253 SGTC_720 r052-1644 49.9 µM -0.0810717340189805 0.480091143273675 no 1753 0.467692452329492 2614 1422863 YOR257W CDC31 SGTC_2232 chlorophetanol 41.5365 µM -0.0819193576459415 0.479732954543764 no 1754 0.467355420499738 2574 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_670 4204-0025 119 µM -0.0820517660753331 0.47967700286997 no 1755 0.467302774410494 2647 719039 SGTC_918 glabranin 770.725 nM -0.0823214228306193 0.479563055572399 no 1756 0.467195559640477 2596 124049 Also referred to as licorice root. SGTC_829 1635-0120 117 µM -0.0823975312090725 0.479530895196325 no 1757 0.467165299592871 2644 285054 SGTC_3060 1327-0027 12.5 µM -0.0827008955919157 0.479402706790491 no 1758 0.46704468636727 2598 16000455 YPR107C YTH1 SGTC_1665 st014639 11.4 µM -0.0827926061212825 0.479363954385179 no 1759 0.467008224202155 2579 981133 YIL048W NEO1 SGTC_518 1021-0119 62.6 µM -0.0828382625018042 0.479344662293991 no 1760 0.466990072294932 2603 1097762 SGTC_1611 st001856 99.4 µM -0.0828924079010794 0.47932178323296 no 1761 0.466968545441728 2563 647478 SGTC_1557 sumaresinolic acid 42.3 µM -0.0839792635710405 0.478862548434677 no 1762 0.466536459395904 2530 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_793 0488-0545 106 µM -0.0840761952811562 0.478821592727237 no 1763 0.466497925516152 2553 292548 SGTC_2174 5790901 200 µM -0.0842712612879655 0.478739173872233 no 1764 0.466420380636991 2605 786020 SGTC_929 2805-0021 398 µM -0.0846109184244808 0.478595664866763 no 1765 0.466285359275392 2655 3098024 SGTC_2546 rhodinyl acetate 100 µM -0.085203221742395 0.478345416624455 no 1766 0.466049914658816 2575 6708682 SGTC_474 dl-dihydrosphingosine 5 µM -0.0861515841756916 0.477944751170272 no 1767 0.465672958887274 2708 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3164 9100705 49.47 µM -0.0861666455721977 0.477938388189679 no 1768 0.465666972520271 2673 17174235 SGTC_2354 9060492 162 µM -0.0863924579118754 0.477842990039443 no 1769 0.465577221115159 2632 6471895 SGTC_25 0118-0223 35.662 µM -0.0865255238047245 0.47778677475072 no 1770 0.465524333545772 2575 5333628 SGTC_970 1315-0089 19.5 µM -0.0865877767071212 0.47776047541418 no 1771 0.465499591090653 2549 6811083 YLR033W RSC58 SGTC_2912 7964298 10.93 µM -0.0866521081882636 0.477733298063839 no 1772 0.465474022643231 2617 2975850 SGTC_174 3553-0389 74.3 µM -0.0880889537332186 0.477126318353877 no 1773 0.464902987946583 2657 738071 SGTC_2793 7325131 81.82 µM -0.0895600039367919 0.476504944242166 no 1774 0.464318434432398 2627 4176441 SGTC_360 0957-0399 1.01 µM -0.089745850894916 0.47642644620364 no 1775 0.464244589589759 2658 6752301 YPR165W RHO1 SGTC_1563 conessine 56.1 µM -0.0898455940556938 0.476384317064245 no 1776 0.464204957928709 2614 441082 An anti-amoebic, histamine inhibitor. SGTC_1782 st039423 80.636 µM -0.0899464537647932 0.476341716589812 no 1777 0.464164882982699 2604 2068169 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.0902149353140542 0.476228318401169 no 1778 0.464058208029345 2562 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_299 1273-0059 1.44 µM -0.0906513885771681 0.476043978339803 no 1779 0.463884798905867 2595 2848077 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0916120448602005 0.475638254415179 no 1780 0.463503140641309 2601 6857784 SGTC_20 0481-0013 4.944 µM -0.0933202407746285 0.474916876986833 no 1781 0.462824576218093 2552 182045 SGTC_1170 0310-0127 64.8 µM -0.0940429507238352 0.474611698527992 no 1782 0.462537519078258 2644 774975 SGTC_226 1,3-diallylurea 8.28947 mM -0.0948438766472738 0.47427350924823 no 1783 0.462219417702458 2670 74537 YKL182W FAS1 SGTC_1981 st071826 47 µM -0.0948511561299798 0.474270435586672 no 1784 0.46221652664238 2648 11838600 SGTC_2463 5473429 200 µM -0.0951166544137624 0.474158333632144 no 1785 0.462111084871124 2651 5399405 SGTC_2657 nystatin 74.44 µM -0.0951338707371446 0.474151064414644 no 1786 0.462104247556699 2627 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_961 1252-1571 372 µM -0.0952181854716904 0.474115464479062 no 1787 0.462070762848428 2631 6813498 SGTC_674 0498-0004 451 µM -0.0967266278596652 0.473478594963674 no 1788 0.461471746501737 2597 4231473 SGTC_1399 3562-5772 25 µM -0.09699365487046 0.473365862265036 no 1789 0.461365716685727 2569 23847490 SGTC_2308 7584454 197.62 µM -0.0975597418596536 0.473126880346584 no 1790 0.461140946646181 2623 893577 SGTC_2140 5586273 200 µM -0.0976663285733914 0.473081884282788 no 1791 0.461098626798795 2569 854421 SGTC_3178 9107506 49.47 µM -0.0980633193741041 0.472914295845437 no 1792 0.460941006998359 2672 8897194 SGTC_1443 4112-3303 14 µM -0.0982000732029178 0.47285656674876 no 1793 0.460886712169443 2578 704433 SGTC_532 1548-0774 215 µM -0.0990571003807432 0.472494795358092 no 1794 0.460546466719666 2776 5932993 SGTC_1780 st038448 24.544 µM -0.0993457375389913 0.472372959896748 no 1795 0.460431882351206 2781 728868 YDL195W SEC31 SGTC_2035 5154463 94.595 µM -0.100934616759509 0.471702331111293 no 1796 0.459801181609908 2647 2769623 SGTC_3263 9137018 49.47 µM -0.101016547781003 0.471667752100714 no 1797 0.459768662070398 2585 43844957 SGTC_3085 9117376 49.47 µM -0.101421596749294 0.471496804213059 no 1798 0.459607896570815 2664 16480349 SGTC_1531 st059297 52.4 µM -0.101590275857767 0.471425616003882 no 1799 0.459540949127621 2686 7566702 SGTC_1494 4358-1428 177 µM -0.102005102813569 0.471250549082283 no 1800 0.459376312377231 2592 1564571 SGTC_1468 k284-1086 134 µM -0.103356326761224 0.470680338873254 no 1801 0.458840086322794 2606 15996457 SGTC_639 0833-0042 114 µM -0.103910227690068 0.470446612566359 no 1802 0.458620295262744 2611 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_566 0958-0068 16.5 µM -0.104884476001867 0.470035539504688 no 1803 0.458233738687562 2669 6815365 SGTC_294 k038-0071 157 µM -0.106435568864098 0.469381139473057 no 1804 0.45761838673705 2647 24152826 SGTC_925 2064-1272 59.6 µM -0.107632166935221 0.468876355829471 no 1805 0.457143739840282 2628 6815817 SGTC_2710 st078562 53.7235 µM -0.108597757734942 0.468469058795918 no 1806 0.456760769652464 2574 17250908 SGTC_1360 1598-0022 39.8 µM -0.109001634755268 0.468298708700866 no 1807 0.456600596857724 2692 761525 SGTC_2603 homopterocarpin 100 µM -0.109243840154374 0.468196552383454 no 1808 0.456504544474497 2686 101795 A weak amylase inhibitor. SGTC_1923 st058458 19.1 µM -0.109278826823721 0.468181796034405 no 1809 0.456490669878243 2750 3534982 SGTC_1872 amphotericin b 148 nM -0.109334894612651 0.468158148379759 no 1810 0.456468435293521 2676 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_311 1315-0136 58 µM -0.110803185340015 0.467538909131023 no 1811 0.455886209686234 2735 6759207 SGTC_2932 9016711 44.54 µM -0.111121122122491 0.467404832264729 no 1812 0.455760149718437 2634 7117328 SGTC_1647 st011722 22.4 µM -0.111262889741238 0.467345048746784 no 1813 0.455703941169352 2705 2854783 SGTC_2290 7904846 200 µM -0.111909538349125 0.467072365875733 no 1814 0.45544756680294 2662 2962154 SGTC_2130 NSC 7 2.4545 µM -0.112342622572357 0.466889748816372 no 1815 0.455275873879885 2678 21448 SGTC_3258 9138477 49.47 µM -0.112570483642571 0.466793670258027 no 1816 0.455185543455568 2618 4970355 SGTC_1432 4049-0298 68.4 µM -0.112701868008496 0.466738272378345 no 1817 0.45513346011545 2670 741646 SGTC_845 0330-0138 4.51 µM -0.113459736324881 0.466418731765163 no 1818 0.454833041329398 2588 9039800 SGTC_108 0509-0257 621.132 µM -0.11352188951672 0.466392527023658 no 1819 0.454808404965518 2694 536624 SGTC_1310 1188-0297 994 nM -0.114204423985057 0.466104769604768 no 1820 0.454537872511968 2657 1588352 SGTC_2701 st077767 14.721 µM -0.114961928956061 0.465785425276265 no 1821 0.454237649103987 2626 5721188 SGTC_1659 st012954 42.1 µM -0.115209324803539 0.465681134405183 no 1822 0.454139603885176 2716 24207262 SGTC_3200 9114385 49.47 µM -0.115210913372237 0.465680464744262 no 1823 0.454138974330012 2719 17018030 YLR208W SEC13 SGTC_591 4299-0174 154 µM -0.116973609382181 0.46493746078796 no 1824 0.453440483275209 2656 5509088 SGTC_1629 st005085 44.9 µM -0.117835456749907 0.464574222965187 no 1825 0.45309901741242 2624 24207091 SGTC_3133 9127736 49.47 µM -0.118914395305788 0.464119530623218 no 1826 0.452671588441097 2593 27243420 SGTC_607 4491-0986 66.8 µM -0.119734590709771 0.46377391059016 no 1827 0.452346699020129 2698 698981 YDR232W HEM1 SGTC_2034 5197015 53.07 µM -0.121054987621848 0.463217569469201 no 1828 0.451823740785314 2751 780676 SGTC_2532 xanthone 78.9 µM -0.121375208576216 0.463082657135269 no 1829 0.451696926188463 2717 7020 An insecticide. SGTC_2928 9011484 9.79 µM -0.122408719300013 0.462647257636537 no 1830 0.45128766671973 2704 2994751 SGTC_1350 1495-0454 146 µM -0.122721303148929 0.462515580467227 no 1831 0.451163896952794 2750 1069057 SGTC_1712 st032288 53.4 µM -0.122829377289255 0.462470054767686 no 1832 0.451121105343008 2643 2883011 SGTC_1617 st002906 78 µM -0.123399466869167 0.462229915489341 no 1833 0.450895389612209 2624 5150859 SGTC_281 1672-3440 14.9 µM -0.123756469707003 0.462079541909901 no 1834 0.450754049456728 2712 6833000 SGTC_486 niguldipine 82 µM -0.124670306930781 0.461694648217396 no 1835 0.450392282798642 2602 1236 A calcium channel blocker. SGTC_1546 5-methoxyflavanone 78.7 µM -0.126004488246461 0.461132776800503 no 1836 0.44986418589409 2700 147795 SGTC_2837 9008476 45.46 µM -0.126200967542843 0.461050038876085 no 1837 0.449786422750975 2825 2992805 SGTC_3278 9139605 49.47 µM -0.126610291619905 0.460877676899802 no 1838 0.449624425482297 2856 7958859 SGTC_2930 9013230 14.89 µM -0.127656072098581 0.46043734341432 no 1839 0.449210577483322 2709 2995857 SGTC_1427 4048-4900 550 nM -0.127674158392344 0.460429728473828 no 1840 0.449203420656677 2737 24132586 SGTC_1203 3992-3522 103 µM -0.127697260204093 0.460420001851986 no 1841 0.44919427919136 2911 5322312 SGTC_1516 st013856 110 µM -0.127904746348285 0.460332644429793 no 1842 0.449112177429244 2768 5281404 A mutagen and neurotoxin. SGTC_376 3970-0862 59.1 µM -0.129337373048837 0.459729521322393 no 1843 0.448545350177859 2725 3135186 SGTC_2739 tacrine 100.86 µM -0.130008662965757 0.459446946029671 no 1844 0.448279786404414 2723 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_160 3453-0671 289.699 µM -0.130236541574403 0.459351026604592 no 1845 0.448189642386735 2658 5322268 SGTC_1033 k072-0102 21.3 µM -0.130544267803375 0.459221501208579 no 1846 0.448067916564754 2634 5965931 SGTC_766 1391-0721 126 µM -0.130692140766602 0.459159261370856 no 1847 0.448009424888559 2810 1020919 YIL115C NUP159 SGTC_1734 st037168 69.4 µM -0.130909909257187 0.459067604277888 no 1848 0.447923287846568 2746 708907 SGTC_1726 st035556 14.5795 µM -0.131392125678421 0.458864650822939 no 1849 0.447732558730183 2878 5919439 SGTC_235 0330-0087 5 mM -0.131465793213788 0.458833646847235 no 1850 0.447703422369973 2645 46494818 YHR062C RPP1 SGTC_194 1486-1323 56.904 µM -0.131827942585357 0.458681235045288 no 1851 0.447560192221289 2664 5178754 SGTC_206 4546-0025 72.014 µM -0.133339060594104 0.458045341663053 no 1852 0.446962618750526 2666 6620745 YIL048W NEO1 SGTC_2023 5144124 124 µM -0.133470861852828 0.457989883459086 no 1853 0.446910503470077 2667 2830192 SGTC_2167 5876490 200 µM -0.134575953157913 0.457524924892052 no 1854 0.446473577612014 2897 686534 SGTC_962 1254-0300 21.5 µM -0.135089305375932 0.45730895567561 no 1855 0.446270632870748 2642 7340576 SGTC_2197 6588183 93.1375 µM -0.135499683708843 0.457136317025563 no 1856 0.446108407157495 2665 884136 SGTC_3344 9148862 3.898 µM -0.135539253190775 0.457119671296139 no 1857 0.446092765513155 2766 4905352 SGTC_2080 5212524 12.4 µM -0.135654938568373 0.457071006256273 no 1858 0.4460470360671 2651 260183 SGTC_2453 5731132 22.18 µM -0.136057695943171 0.456901584479819 no 1859 0.445887835103893 2751 1362040 SGTC_131 0141-0277 33.849 µM -0.138437252113033 0.455900773908253 no 1860 0.444947428756072 2790 1547771 SGTC_1397 3532-0190 20.1 µM -0.139654144303563 0.455389072489684 no 1861 0.444466629394198 2618 5322280 SGTC_743 1275-0778 158 µM -0.139702619175769 0.455368690402544 no 1862 0.444447478450257 2760 2849257 YMR203W TOM40 SGTC_1716 st033144 30.6155 µM -0.139896773009719 0.455287056288316 no 1863 0.444370775490906 2729 674617 SGTC_24 0417-1663 219 µM -0.141552622105245 0.454590913391341 no 1864 0.443716696032922 2721 4329390 SGTC_476 mead acid 10 µM -0.142115027837913 0.454354501509059 no 1865 0.443494574079541 2662 5312531 An omega 9 fatty acid. SGTC_3335 9143315 29.6265 µM -0.142382849444542 0.454241926168933 no 1866 0.4433888042625 2722 4899691 SGTC_1812 st052057 4.327 µM -0.143784981823171 0.453652618203572 no 1867 0.442835131202846 2641 3645418 SGTC_901 1112-0062 60.1 µM -0.143810492757217 0.453641897049724 no 1868 0.442825058493533 2658 1908457 SGTC_1969 st069479 40.1 µM -0.144721238422372 0.453259171812453 no 1869 0.442465484927979 2797 3895485 SGTC_588 3970-1144 52.9 µM -0.144988695870099 0.453146785639906 no 1870 0.44235989843424 2808 1888707 SGTC_1241 0364-0022 50.8 µM -0.145212936877255 0.453052561996791 no 1871 0.442271376024306 2746 4563895 SGTC_913 3487-1245 167 µM -0.145298256926218 0.453016712129949 no 1872 0.442237695446676 2638 4016153 SGTC_1057 3448-5381 134 µM -0.145445028719664 0.452955042301386 no 1873 0.442179757418266 2790 5497911 SGTC_1299 1079-1439 3.74 µM -0.145673877945323 0.45285888785765 no 1874 0.442089421868243 2683 323161 SGTC_1351 1496-0003 46.5 µM -0.145943812688436 0.452745474269429 no 1875 0.441982872163045 2770 3891978 SGTC_429 1112-0049 25.5 µM -0.146516027330759 0.452505069973685 no 1876 0.441757019234565 2683 2836170 SGTC_2811 7967822 32.47 µM -0.147138959601033 0.452243377498505 no 1877 0.4415111696038 2774 2232244 SGTC_512 prima-1 270 µM -0.147814849524472 0.451959461099678 no 1878 0.441244444925993 2827 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2349 9023730 187.07 µM -0.147963290248132 0.451897109918198 no 1879 0.441185869714871 2778 4126287 SGTC_2006 4011487 200 µM -0.148119337999267 0.451831564752999 no 1880 0.44112429413213 2787 45595294 SGTC_344 k064-0035 6.43 µM -0.14991876253814 0.451075842836587 no 1881 0.440414354324575 2677 5088750 SGTC_2879 9041815 71.43 µM -0.152650888913164 0.449928744868251 no 1882 0.439336795848554 2672 4942971 SGTC_1129 3453-1384 223 µM -0.15278612845646 0.449871974602886 no 1883 0.439283468591201 2907 1084452 SGTC_2496 diffractaic acid 79.83 µM -0.153883844273955 0.449411218304513 no 1884 0.438850661384383 2922 94870 An apoptosis inducer which activates caspases. SGTC_2223 6903751 107.57 µM -0.15461453603842 0.449104554807485 no 1885 0.438562604854055 2786 5598863 SGTC_2244 6635614 200 µM -0.155704804009821 0.448647037609287 no 1886 0.438132855153623 2644 836499 SGTC_2485 5633444 17.78 µM -0.155784815169726 0.448613464617662 no 1887 0.438101320111766 2769 5724239 SGTC_1624 st003710 6.25 µM -0.156365512001814 0.448369813026767 no 1888 0.437872460093713 2847 24207033 SGTC_1956 st077085 54 µM -0.156607009607024 0.448268490019571 no 1889 0.437777288925003 2723 24208685 SGTC_3037 9091026 49.47 µM -0.157822877992121 0.447758410310352 no 1890 0.437298185276986 2746 25236398 YIL048W NEO1 SGTC_810 3825-7150 143 µM -0.158216149675522 0.447593443872271 no 1891 0.437143239216959 2815 22330411 YGL099W LSG1 SGTC_354 2783-3500 4.88 µM -0.158331374496706 0.447545112008139 no 1892 0.437097843336548 2718 6740761 SGTC_1392 3455-1037 33.9 µM -0.159182249372899 0.44718823069682 no 1893 0.436762644244142 2829 981132 SGTC_682 0kpi-0099 17 µM -0.161019827455127 0.44641764403573 no 1894 0.436038892178931 2790 1714895 YML126C ERG13 SGTC_895 0964-0006 13.7 µM -0.161545193235258 0.446197369444164 no 1895 0.435832009849336 2663 6738897 SGTC_295 k015-0027 31 µM -0.16187219758239 0.446060271921293 no 1896 0.435703248578503 2789 3887424 SGTC_3284 9108171 64.8615 µM -0.162255812579181 0.445899448439746 no 1897 0.435552204979982 2796 8687505 SGTC_700 3453-2283 142 µM -0.162994081092787 0.445589968110177 no 1898 0.435261547477664 2859 565664 SGTC_1973 st070275 50.2 µM -0.163143983556705 0.44552713341206 no 1899 0.435202534902871 2641 17118334 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.163157744223042 0.445521365414539 no 1900 0.435197117770343 2867 1273210 SGTC_802 4112-3352 742 µM -0.163199191478309 0.445503992221925 no 1901 0.435180801390167 2841 704594 SGTC_3225 9130819 49.47 µM -0.164118990605059 0.445118472635131 no 1902 0.434818736087682 2712 4547121 SGTC_2325 6158266 200 µM -0.165797462401977 0.444415101143108 no 1903 0.434158171597195 2783 3623240 SGTC_2961 9083290 32.55 µM -0.165923077914522 0.444362468384092 no 1904 0.434108742838952 2682 17741490 SGTC_423 5-fluorouracil 457 µM -0.166837275228038 0.443979450344394 no 1905 0.433749044159793 2673 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.166980308462419 0.44391952893637 no 1906 0.433692771477245 2834 521171 SGTC_237 nikkomycin 200 µM -0.167750809518716 0.443596762350099 no 1907 0.433389661150694 2838 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3343 9148379 18.9835 µM -0.168355853671585 0.443343332668582 no 1908 0.433151667992504 2845 1955036 SGTC_392 N-ethylmaleimide 8.33 µM -0.169269763921868 0.442960574850051 no 1909 0.432792228834235 2756 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1881 5652484 16 µM -0.169952178959688 0.442674805007111 no 1910 0.43252387254374 2799 2255129 SGTC_2795 7780010 54.55 µM -0.171395618962583 0.442070444859948 no 1911 0.431956349685589 2831 953673 SGTC_2565 isoliquiritigenin 100 µM -0.174110204593142 0.440934229506492 no 1912 0.430889426792961 2868 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3264 9137442 49.47 µM -0.174482587851649 0.440778402691594 no 1913 0.430743106876516 2947 17015726 SGTC_1302 1159-0335 255 µM -0.175892286529229 0.440188586029311 no 1914 0.430189282667498 2703 649284 SGTC_2995 9067767 71.4286 µM -0.175912420249857 0.440180163056721 no 1915 0.430181373783373 2800 11673567 SGTC_54 0159-0055 9 µM -0.17638725446578 0.439981523297715 no 1916 0.429994858571811 2934 3319099 SGTC_1977 st070720 65.3 µM -0.176466267691399 0.439948470766785 no 1917 0.429963823636456 2823 682188 SGTC_547 1120-0019 610 nM -0.176493522233873 0.439937069840784 no 1918 0.429953118656029 2694 3676939 SGTC_1254 0550-0035 264 µM -0.176612310802382 0.439887379634969 no 1919 0.429906461739636 2850 15121435 SGTC_2526 patulin 37.61 µM -0.177525524112268 0.439505406900721 no 1920 0.429547809143236 2864 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1999 st074831 12.5 µM -0.17831946719042 0.439173367466747 no 1921 0.429236045607298 2759 17112523 SGTC_2833 9001315 45.46 µM -0.17849097410708 0.439101646199884 no 1922 0.429168704500443 2762 2989378 SGTC_1384 3089-0840 101 µM -0.179688082924503 0.438601091520736 no 1923 0.428698724806559 2801 1069836 SGTC_2733 amorolfine 100 µM -0.179970219248959 0.43848313434406 no 1924 0.428587974012804 2736 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_642 0335-0876 158 µM -0.180722270515855 0.43816873914993 no 1925 0.428292788635783 2714 6812350 SGTC_3240 9133527 49.47 µM -0.180981483030987 0.438060384334786 no 1926 0.428191055200749 2752 17617455 SGTC_398 bronopol 33.3 µM -0.183284095992217 0.437098061488959 no 1927 0.42728755629051 2704 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_220 paclitaxel 373.376 µM -0.186349044719307 0.435817716491801 no 1928 0.42608552442383 2850 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2955 9076254 12.21 µM -0.186621031074426 0.435704129790164 no 1929 0.425978888011853 2808 16459619 SGTC_3052 9092717 49.47 µM -0.186723469174929 0.435661351055457 no 1930 0.425938726989964 2906 25237534 SGTC_1738 st035555 74 µM -0.187355752656814 0.43539732255175 no 1931 0.42569085625419 2843 5331140 SGTC_1094 duloxetine 25.4 µM -0.187615726619864 0.435288771149816 no 1932 0.425588948554697 2726 60834 A selective serotonin reuptake inhibitor. SGTC_823 0417-1665 178 µM -0.187685986236417 0.435259435279896 no 1933 0.425561408203818 2837 3429856 SGTC_3035 9091303 49.47 µM -0.188880235585483 0.434760848653732 no 1934 0.425093342231834 2736 25237002 SGTC_2219 9098279 200 µM -0.189026440369211 0.434699816794966 no 1935 0.425036046963044 2752 902349 SGTC_1297 1068-0111 14.1 µM -0.190226030844753 0.43419911753774 no 1936 0.424566006932934 2727 767057 SGTC_2893 9048488 25.97 µM -0.19024126760159 0.434192758517118 no 1937 0.424560037345802 2755 6467338 SGTC_122 0236-0016 402.397 µM -0.193384138483559 0.432881455948299 no 1938 0.423329068314329 2782 6808838 SGTC_3177 9107506 49.47 µM -0.193553207354323 0.432810936016739 no 1939 0.423262870161931 2852 8897194 SGTC_216 k038-0035 28.382 µM -0.193701743417764 0.432748982243382 no 1940 0.423204713324976 2749 4444231 YPR107C YTH1 SGTC_2196 6573537 42.6665 µM -0.193958811868276 0.432641763970587 no 1941 0.423104066382915 2836 2903087 SGTC_2419 paclitaxel 166.5 µM -0.194603703172572 0.432372814137934 no 1942 0.422851601886964 2687 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1993 st073995 70.8 µM -0.194610529878652 0.432369967249621 no 1943 0.422848929511439 2768 3098394 SGTC_2443 5493264 126.67 µM -0.194926327236121 0.432238276566284 no 1944 0.422725311676966 2915 5340055 SGTC_1756 st041558 35.5 µM -0.195324106722264 0.432072409223268 no 1945 0.422569613038823 2908 3955792 SGTC_3268 9137683 49.47 µM -0.196235868556879 0.431692265120782 no 1946 0.422212777378195 2726 1953228 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.196269293353023 0.431678330401425 no 1947 0.422199697147893 2739 91467 include heat shock SGTC_470 aa-861 153 µM -0.196462644370464 0.431597724483205 no 1948 0.422124034172169 2772 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1664 st014217 9.02 µM -0.196720905407929 0.431490062733096 no 1949 0.422022974804012 2763 3982782 SGTC_1249 0481-0015 10.2 µM -0.197091529510777 0.431335568881062 no 1950 0.421877955947168 2741 4227577 SGTC_861 0443-0273 110 µM -0.198231894015427 0.430860276398035 no 1951 0.421431817390128 2842 6149169 SGTC_2747 doxorubicin 7.63 µM -0.199752561200799 0.43022663346057 no 1952 0.420837052088779 2746 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_561 1550-0330 72.9 µM -0.201962040647694 0.429306291633256 no 1953 0.419973199908695 2765 6812934 SGTC_2612 dictamnine 15.46 µM -0.20370708021681 0.42857967994334 no 1954 0.419291204499952 2871 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_458 nppb 133 µM -0.204262802331698 0.428348335203688 no 1955 0.419074068279139 2937 4549 A chloride channel blocker. SGTC_868 0527-0199 213 µM -0.204826874446935 0.428113539574262 no 1956 0.418853694683995 2811 2849450 SGTC_584 0986-0246 15.4 µM -0.205890006862099 0.427671078800502 no 1957 0.41843841579545 2749 53315 YDR232W HEM1 SGTC_2719 novobiocin 32.65 µM -0.206173383332608 0.42755315682363 no 1958 0.418327739107272 2875 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2620 irigenin 100 µM -0.206801196380757 0.42729192688029 no 1959 0.41808256088627 2947 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_576 1073-0113 22.7 µM -0.207189992627282 0.427130166636799 no 1960 0.41793074123809 2807 5439563 SGTC_2310 7668677 200 µM -0.207499419080081 0.427001437269664 no 1961 0.417809923153517 2981 2197143 SGTC_2911 7942208 15.64 µM -0.20753962884599 0.426984709542725 no 1962 0.417794223491422 2864 1243384 SGTC_389 tpck 16.7 µM -0.207908431866389 0.426831289356227 no 1963 0.417650232677342 2840 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2263 7948595 193.29 µM -0.208119015663044 0.426743692527414 no 1964 0.417568019938141 2769 2971371 SGTC_2757 clomiphene 4.22 µM -0.20886514635321 0.426433352634746 no 1965 0.417276756616482 2979 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1139 k015-0024 46.9 µM -0.209653172000356 0.426105636728956 no 1966 0.416969188253655 2787 2766652 SGTC_1688 st021091 57.6 µM -0.209717664163058 0.426078818655169 no 1967 0.416944019049565 2811 3656366 SGTC_2337 9009472 200 µM -0.210186570373224 0.425883841507194 no 1968 0.416761030371508 2955 5742383 SGTC_3049 9092223 49.47 µM -0.211661199761744 0.425270790211424 no 1969 0.416185680163526 2890 8623917 SGTC_1861 st057647 17.4 µM -0.212136764021083 0.425073121166073 no 1970 0.416000169404232 2963 688668 SGTC_2397 5161689 200 µM -0.212553921245644 0.424899744604327 no 1971 0.415837457793313 2977 2259942 SGTC_1767 st044992 70.3 µM -0.212663171522393 0.42485434101185 no 1972 0.415794847253485 2842 9600693 SGTC_121 0557-0495 61.343 µM -0.212729129587762 0.424826929819045 no 1973 0.41576912231714 2779 3104427 SGTC_2116 5511452 16.8835 µM -0.212874928368959 0.42476633929996 no 1974 0.41571225922 2904 870744 SGTC_626 0214-0009 33 µM -0.214870163564579 0.423937346019173 no 1975 0.414934273794691 2896 3437874 SGTC_264 promethazine 12.5 mM -0.215500732218887 0.423675423057164 no 1976 0.414688470622986 2807 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3179 9107801 49.47 µM -0.216441250489783 0.423284817209532 no 1977 0.414321907487513 2808 4818259 SGTC_3135 9127742 49.47 µM -0.216581737034767 0.423226478323471 no 1978 0.41426715983061 2852 3643468 SGTC_3221 9128209 49.47 µM -0.21761887043161 0.422795847199591 no 1979 0.413863040183483 2830 16460723 SGTC_2736 butenafine 14.65 µM -0.217952884024431 0.422657180072697 no 1980 0.413732910982917 2819 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1426 4048-4480 71.7 µM -0.221727168348717 0.421090940281539 no 1981 0.412263139602556 2901 14224343 SGTC_1863 st057641 20.1 µM -0.222696462146683 0.420688906421344 no 1982 0.411885877511679 2779 3921635 SGTC_519 k048-0011 62.8 µM -0.223068663018979 0.420534550669363 no 1983 0.411741033579815 2924 6836379 SGTC_2216 7189485 200 µM -0.225142053260824 0.419674917423468 no 1984 0.410934383445664 2902 731273 SGTC_745 0469-0705 296 µM -0.225229328493194 0.419638741249459 no 1985 0.410900437348661 2985 3486736 SGTC_176 1486-1328 72.834 µM -0.225958930680559 0.419336342807736 no 1986 0.410616681401742 2879 22310231 SGTC_2681 menadione 3.18 µM -0.226002755500754 0.419318180236001 no 1987 0.410599638596683 2870 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2088 5278280 127.392 µM -0.226401714358914 0.41915284533749 no 1988 0.410444497340185 2894 791502 SGTC_999 SEC7.066 22.7 µM -0.227154482976916 0.418840924946463 no 1989 0.410151809926584 2819 740511 YDR170C SEC7 SGTC_2386 9075165 157.42 µM -0.227855101206087 0.418550659641112 no 1990 0.409879444304643 2793 16452277 SGTC_1076 itraconazole 331 nM -0.228261199194261 0.41838243401412 no 1991 0.409721593441832 2791 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1520 flindersine 88 µM -0.231322713209001 0.417114687901183 no 1992 0.408532051280191 3093 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_157 1348-1695 65.819 µM -0.231365617416405 0.417096927734152 no 1993 0.408515386936956 2818 5380510 SGTC_2689 tacrolimus 100 µM -0.231723677075836 0.416948715785744 no 1994 0.408376320105577 2904 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2301 7769476 200 µM -0.232431605099423 0.416655717274694 no 1995 0.408101401834278 2889 977820 SGTC_717 1532-0246 73.2 µM -0.232450236942037 0.416648006519048 no 1996 0.4080941669153 2899 9561992 SGTC_3186 9110464 49.47 µM -0.232734487430117 0.416530373927707 no 1997 0.407983793675666 2939 17018021 SGTC_3026 9090633 49.47 µM -0.232958642497041 0.416437616151481 no 1998 0.407896760377862 2807 25236842 SGTC_2504 purpurogallin 52.29 µM -0.23376822965335 0.41610263907253 no 1999 0.407582457648253 2807 5281571 An antioxidant. SGTC_1065 prochlorperazine maleate 2.48 µM -0.234147998818709 0.415945525686945 no 2000 0.407435041891779 2834 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1511 0906-3109 28.5 µM -0.234362136324465 0.415856941296818 no 2001 0.40735192548591 2787 2882180 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.235821756221358 0.415253239940213 no 2002 0.406785492596847 2754 4000243 SGTC_1278 0874-0585 172 µM -0.23708707863734 0.414730062162172 no 2003 0.40629461819172 2885 766306 SGTC_3213 9129884 49.47 µM -0.237679126798215 0.414485317580039 no 2004 0.4060649871008 2935 17190742 SGTC_1632 st005650 90 µM -0.238954017738395 0.413958407993097 no 2005 0.405570619226221 2951 2759605 SGTC_2821 7996764 71.43 µM -0.239906048625157 0.413565036687881 no 2006 0.405201545826629 3051 2987135 SGTC_1820 st053765 18.6 µM -0.241753661654704 0.412801866064274 no 2007 0.404485523281609 2888 3690829 SGTC_1379 2144-0755 36.5 µM -0.241905899736929 0.412738997618951 no 2008 0.404426539278681 2983 5392327 SGTC_1636 st007707 68.9 µM -0.245951269463056 0.411069241078355 no 2009 0.402859977609894 3015 403051 SGTC_2028 5153890 36.43 µM -0.247412786629302 0.410466383259498 no 2010 0.402294389720807 2850 2830968 YPR165W RHO1 SGTC_685 1278-0033 54.9 µM -0.247594636966162 0.410391387002316 no 2011 0.402224030317051 2980 3590572 SGTC_536 3852-0578 10.6 µM -0.250235950910863 0.409302462793458 no 2012 0.401202442314372 3015 2869208 SGTC_2120 5538279 151.968 µM -0.250418903564083 0.409227063421853 no 2013 0.401131706150846 2886 2058197 SGTC_3055 9094636 49.47 µM -0.251112552930414 0.408941223665838 no 2014 0.40086354547978 3013 25236176 SGTC_2575 plumbagin 510 nM -0.251528726664268 0.408769749588839 no 2015 0.400702677628156 2805 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2568 diosmetin 100 µM -0.251828429937192 0.408646275092892 no 2016 0.400586840712217 3002 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2964 9083345 53.42 µM -0.252041348817039 0.408558560333308 no 2017 0.400504551738815 2904 17741579 SGTC_305 1682-2595 20.8 µM -0.252568194876243 0.40834153880246 no 2018 0.400300955053307 2913 226033 SGTC_1328 1441-0025 69.2 µM -0.253418827162677 0.407991200700293 no 2019 0.399972290209526 2822 4562601 SGTC_2107 5363541 170.161 µM -0.254249200127159 0.407649277460875 no 2020 0.399651521432965 2901 244052 SGTC_282 k297-0036 65.7 µM -0.255455080814541 0.407152856455616 no 2021 0.399185816592792 2997 5061378 SGTC_1234 0326-0494 15.5 µM -0.255595913170237 0.407094890163503 no 2022 0.39913143721254 3005 1547813 SGTC_2351 9026858 72.31 µM -0.256247496111996 0.406826726543575 no 2023 0.398879867990556 2836 1409300 SGTC_447 ml7 120 µM -0.257310346590131 0.406389396615828 no 2024 0.398469602936642 2916 4216 Selective myosin light chain kinase inhibitor. SGTC_1216 1165-0504 9.65 µM -0.257321923358929 0.40638463377716 no 2025 0.398465134868776 2976 6304004 SGTC_3217 9129673 49.47 µM -0.257600946398093 0.406269844130892 no 2026 0.398357449618311 3037 17248312 SGTC_1731 st035964 63 µM -0.257761372210542 0.406203848846776 no 2027 0.398295538902236 2895 6739575 SGTC_780 0109-0199 192 µM -0.258958694759229 0.405711383705878 no 2028 0.397833555210544 3038 610414 SGTC_2362 9071156 126 µM -0.259166569305723 0.405625898975662 no 2029 0.397753361948467 3041 653133 SGTC_880 0833-0487 87.2 µM -0.259745218768409 0.405387963333587 no 2030 0.397530154935741 2857 76075 SGTC_2696 st077691 74.316 µM -0.259891175388854 0.405327952754525 no 2031 0.397473859234624 3007 757133 SGTC_1982 st072467 71.9 µM -0.260840642615402 0.404937630346309 no 2032 0.397107700389759 2819 3163533 SGTC_3019 9081971 49.47 µM -0.262796590243922 0.404133846064725 no 2033 0.396353681892551 3030 16451803 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.262820335163501 0.404124090719132 no 2034 0.396344530592805 2815 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2002 4023503 131 µM -0.263274693637857 0.403937433904496 no 2035 0.396169431695993 2963 4736863 YCR052W RSC6 SGTC_137 0438-0332 85.389 µM -0.263806381740099 0.403719036771973 no 2036 0.395964558405729 2900 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1273 0849-0096 14.1 µM -0.26471370647437 0.403346411830567 no 2037 0.395615008911288 2904 5286025 SGTC_959 1222-0044 107 µM -0.265106086127439 0.403185294425389 no 2038 0.395463869493406 3002 6083612 SGTC_1684 st024538 14.6195 µM -0.265259000656032 0.403122509705841 no 2039 0.395404973108976 2872 6732859 SGTC_2287 7945887 168.79 µM -0.265323671410417 0.403095957485331 no 2040 0.395380065314126 2975 1245853 SGTC_2822 7994718 71.43 µM -0.26544386382321 0.403046610624977 no 2041 0.395333774613395 2805 1018011 SGTC_309 k408-0051 1.48 µM -0.266020583190374 0.402809851031897 no 2042 0.395111678456024 2898 3640463 SGTC_1454 4239-0054 42.6 µM -0.266308438812702 0.402691691493237 no 2043 0.395000837235313 3068 1340767 SGTC_797 k781-0471 270 µM -0.266340334606225 0.402678599392327 no 2044 0.394988556015343 2893 23738129 SGTC_932 2857-0803 154 µM -0.266681071652899 0.40253874563752 no 2045 0.39485736445595 3104 674898 SGTC_1961 st076550 68.7 µM -0.266987287982166 0.402413071372427 no 2046 0.39473947433244 2990 1579337 SGTC_58 0957-0393 9 µM -0.268777245081921 0.40167865713399 no 2047 0.394050552495447 2959 6997992 SGTC_2177 5811945 192 µM -0.269627018391124 0.401330118945151 no 2048 0.393723606121343 3043 5343475 SGTC_259 usnic acid 108.925 µM -0.269869200636677 0.40123080121355 no 2049 0.393630441321453 3083 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1028 k015-0029 4.8 µM -0.270515857758592 0.400965641636969 no 2050 0.393381709410755 2864 4588309 SGTC_2220 6782180 200 µM -0.270745556860506 0.400871465266323 no 2051 0.393293367805728 2939 833803 SGTC_1741 st038134 10.228 µM -0.274468823254325 0.399345737447217 no 2052 0.391862179706497 3128 1272587 SGTC_2139 5578692 56.4705 µM -0.275052917965623 0.399106524705372 no 2053 0.391637791451609 2978 650991 YMR113W FOL3 SGTC_416 estradiol valerate 100 µM -0.275706616172718 0.398838851166487 no 2054 0.391386706777273 2951 13791 A steroid. SGTC_3173 9105693 49.47 µM -0.276417416809311 0.398547849558205 no 2055 0.391113740483711 3055 17096658 SGTC_657 3534-0529 86.7 µM -0.276707089646178 0.398429273735626 no 2056 0.391002513805944 3052 1049549 SGTC_1788 fluconazole 20 µM -0.276941004586295 0.39833352891353 no 2057 0.390912703185717 2994 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1912 st060209 90.8 µM -0.277861532582604 0.397956802763418 no 2058 0.390559327019317 2967 688787 SGTC_2703 st077852 53.4 µM -0.278197197328669 0.39781945558898 no 2059 0.390430493093156 3035 6281836 SGTC_878 0828-0289 13.7 µM -0.279143288823761 0.397432402426725 no 2060 0.390067431621824 2901 745350 YLR208W SEC13 SGTC_997 3996-0078 137 µM -0.279192035327959 0.397412462596361 no 2061 0.390048727804069 2958 735687 SGTC_3254 9136651 49.47 µM -0.279614371128325 0.397239716734561 no 2062 0.389886690088867 2928 16454030 SGTC_2586 curcumin 80 µM -0.280092100429943 0.397044337847053 no 2063 0.389703422595364 3022 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1104 tacrolimus 29.8 µM -0.281221899199965 0.396582382352977 no 2064 0.389270104513593 2929 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1020 4335-0961 93.3 µM -0.282029140826346 0.396252403836277 no 2065 0.388960582872758 2860 669075 SGTC_2036 5160441 105 µM -0.284200108338699 0.39536534038672 no 2066 0.388128516222391 2962 134534 YIL048W NEO1 SGTC_371 0195-0006 7.36 µM -0.284561258100167 0.395217826022789 no 2067 0.3879901480568 2824 3928593 SGTC_395 anisomycin 6.25 µM -0.285764509558432 0.394726457281998 no 2068 0.387529246168667 2964 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1111 tnp00062 510.699 nM -0.286473384544641 0.394437054123554 no 2069 0.387257787849094 3060 676306 SGTC_601 0986-0029 62.9 µM -0.287275891216637 0.394109495491354 no 2070 0.386950540511779 2932 24747981 SGTC_1407 3909-7909 12.3 µM -0.287901016079132 0.393854390551613 no 2071 0.38671125455651 2931 4411780 SGTC_1787 fluconazole 80 µM -0.288546966581733 0.393590834796171 no 2072 0.386464042178855 2988 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1421 4029-0249 71.4 µM -0.289455496727922 0.393220225829701 no 2073 0.386116415671398 3072 2894095 SGTC_2525 harmine 47.85 µM -0.29023588614069 0.39290196544671 no 2074 0.385817892002235 2960 5280953 A monoamine oxidase inhibitor SGTC_1116 jasmonic acid  1.58368 µM -0.290659368124606 0.392729289901108 no 2075 0.385655925016912 3075 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3122 9126309 49.47 µM -0.291521390454284 0.392377863991282 no 2076 0.385326293370237 2982 17591206 SGTC_438 sphingosine 6.67 µM -0.293502846917612 0.391570404618667 no 2077 0.384568911871201 2908 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2900 5328528 85.29 µM -0.295627899329061 0.390704947714621 no 2078 0.383757132444955 2924 795359 SGTC_3252 9135871 49.47 µM -0.296548902368385 0.390330024357447 no 2079 0.383405463371816 3079 17682838 SGTC_645 0845-0943 5.41 µM -0.299148506295599 0.389272324690097 no 2080 0.38241336857743 2988 1885106 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.300912757746121 0.388554971011113 no 2081 0.381740510833843 2949 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1930 st074634 34.3 µM -0.301867538073 0.388166910713121 no 2082 0.381376521446542 2917 684253 YOR116C RPO31 SGTC_3000 9075062 71.4286 µM -0.302225116616071 0.388021605432758 no 2083 0.381240229328513 2962 17057871 SGTC_1172 0370-0043 85 µM -0.304687392900381 0.387021463799173 no 2084 0.380302126181238 3083 376585 SGTC_327 1273-0057 3.96 µM -0.307264933064962 0.385975306729578 no 2085 0.379320862405202 2991 3108138 SGTC_291 SEC14.278 35.5 µM -0.307892985263561 0.385720521807057 no 2086 0.379081881817493 3073 1068044 SGTC_673 1082-0474 110 µM -0.308936184041794 0.385297431389728 no 2087 0.37868503567001 2985 3098046 SGTC_1822 st052468 42 µM -0.309277456940157 0.385159050849571 no 2088 0.378555238838314 3004 2873678 SGTC_1493 4348-0038 111 µM -0.310414081150072 0.384698273994927 no 2089 0.378123043720982 3007 800424 SGTC_2539 epi(13)torulosol 80 µM -0.311035984906327 0.384446228885746 no 2090 0.377886632730092 3063 6708597 SGTC_2249 haloperidol 116.36 µM -0.311166902541151 0.384393176815998 no 2091 0.377836871419036 2923 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3113 9123498 49.47 µM -0.312039917883569 0.384039458107622 no 2092 0.377505093367615 2980 8897275 SGTC_3069 9117009 49.47 µM -0.312820461275611 0.383723287919634 no 2093 0.377208534581445 3014 41904981 SGTC_60 0986-0278 202 µM -0.313166525384409 0.383583134487592 no 2094 0.377077074526302 2947 3110598 SGTC_3341 9147222 25.867 µM -0.315615808227969 0.382591629197063 no 2095 0.376147068670736 3084 1939759 SGTC_1140 3229-1848 2.98 µM -0.316247994272148 0.382335835712699 no 2096 0.375907140715149 3078 2849525 SGTC_1771 st048882 4.1505 µM -0.316484856982308 0.382240010149438 no 2097 0.375817258661278 2956 4580403 SGTC_3146 9095609 49.47 µM -0.318332041338815 0.381492958099455 no 2098 0.375116540981681 3015 17173999 SGTC_1777 st045864 34.765 µM -0.319732227869772 0.380926978083983 no 2099 0.374585663435355 3036 4691462 SGTC_1281 0884-0031 11.8 µM -0.319751214709683 0.380919305016872 no 2100 0.374578466248857 2983 1548255 SGTC_396 dithiazanine 1.25 µM -0.320477546183194 0.380625811097545 no 2101 0.374303174531864 2976 10578 An antihelmenthic. SGTC_1158 4092-0494 91.8 µM -0.321287104304534 0.380298768146041 no 2102 0.373996414042373 3107 1148199 SGTC_3027 9089541 49.47 µM -0.321444161987007 0.380235330338638 no 2103 0.373936910450821 3065 9943819 SGTC_2412 st077135 33.4 µM -0.322228308298699 0.379918650836838 no 2104 0.373639870160367 3229 13258915 SGTC_1907 st060210 83.7 µM -0.322825208066024 0.379677645283843 no 2105 0.37341381051003 3131 688793 SGTC_405 ebelactone b 50 µM -0.32337709402809 0.379454856180515 no 2106 0.373204837372947 2967 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1232 0279-0259 161 µM -0.32395221491948 0.379222730024897 no 2107 0.372987105946438 3022 1560000 SGTC_1744 st037937 38.9 µM -0.324303122470349 0.379081120625789 no 2108 0.372854277968735 3172 1016152 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.324545294669608 0.378983401043442 no 2109 0.372762618070269 2966 364106 SGTC_903 1134-0042 114 µM -0.326808249133369 0.37807064452621 no 2110 0.371906459915312 3000 701009 SGTC_482 fipronil 114 µM -0.327423849567967 0.377822461233112 no 2111 0.371673665178883 3020 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1423 4048-0112 5.59 µM -0.327925759642343 0.377620150253149 no 2112 0.371483898172479 3065 X1423 SGTC_2266 7929956 200 µM -0.328298605109059 0.377469884637879 no 2113 0.371342949373734 2932 2967153 SGTC_1463 k081-0032 34.1 µM -0.328614751663484 0.37734248456566 no 2114 0.371223448288332 3043 977755 SGTC_31 0508-1974 57.237 µM -0.329582859888094 0.376952441424273 no 2115 0.370857587718783 3102 6810525 SGTC_483 fpl-64176 144 µM -0.331774974607951 0.376069720257864 no 2116 0.370029591160504 3004 3423 SGTC_1261 0712-0010 12.7 µM -0.333227656222077 0.37548511083384 no 2117 0.369481221653451 3178 2840123 SGTC_1826 st055655 41.6 µM -0.334037972167414 0.375159135701396 no 2118 0.369175452553219 3061 676168 SGTC_636 0kpi-0074 126 µM -0.335859119220425 0.374426847501695 no 2119 0.368488553110149 3059 616434 SGTC_2373 9071805 200 µM -0.337183775644299 0.373894483787729 no 2120 0.36798918353073 3160 10149009 SGTC_168 3970-0862 530.542 µM -0.337730301964641 0.373674911351088 no 2121 0.367783218727239 3073 3135186 SGTC_1117 retinoic acid 1.10837 µM -0.339120574353422 0.373116540399183 no 2122 0.367259449868899 3156 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1699 st031318 29.054 µM -0.33913441786962 0.37311098180667 no 2123 0.367254235726031 3111 5340658 SGTC_1062 mesoridazine 14.2 µM -0.339347488612986 0.373025430759485 no 2124 0.36717398598845 2992 4078 A neuroleptic. SGTC_978 1416-0512 87.4 µM -0.339438373923273 0.372988940871049 no 2125 0.367139757233777 3083 6814003 SGTC_2067 5224629 34.075 µM -0.340072357672272 0.372734432040382 no 2126 0.366901018946579 3140 2835000 SGTC_623 k072-0108 16.9 µM -0.340108258949402 0.372720021356942 no 2127 0.366887501196704 3063 5382803 SGTC_856 0433-0016 11.3 µM -0.340130312033939 0.372711169391923 no 2128 0.366879197727673 3092 3911780 SGTC_2553 4-methylesculetin 85.09 µM -0.340176783932918 0.372692516093343 no 2129 0.366861700244437 3061 5319502 SGTC_2953 9074162 66.49 µM -0.341431722418539 0.372188910891651 no 2130 0.366389298643043 3117 16451992 SGTC_2460 5552655 174.22 µM -0.342126171816409 0.371910323103951 no 2131 0.366127971165779 3135 5401989 SGTC_2887 9044784 58.44 µM -0.342385044188089 0.371806490091499 no 2132 0.366030571071312 3014 6465546 SGTC_1674 st016616 23.6 µM -0.342787927412174 0.371644913262703 no 2133 0.365879004421021 2957 625830 SGTC_175 3793-3120 23.7 µM -0.344713168959594 0.37087310532283 no 2134 0.365155008448941 3005 5322297 SGTC_2065 5221596 34.26 µM -0.344847320820286 0.370819344648017 no 2135 0.3651045778958 3144 788581 SGTC_2857 9024691 58.44 µM -0.345481272942095 0.370565325696327 no 2136 0.364866293311893 3108 16478292 SGTC_1431 4049-0260 9.09 µM -0.346256226922662 0.370254885203884 no 2137 0.364575081028809 2997 3854841 SGTC_1298 1079-1278 263 µM -0.347283936827619 0.369843323019704 no 2138 0.364189008636854 3035 2840950 SGTC_120 rhodamine 6G 52.259 µM -0.347380223472782 0.369804771185335 no 2139 0.364152844377907 2986 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_33 0986-0033 35.816 µM -0.348016294504268 0.369550130075558 no 2140 0.363913973139778 3053 2848082 SGTC_1661 st013063 9.66 µM -0.34834249760365 0.369419561940905 no 2141 0.363791490756631 3024 721395 SGTC_680 0417-1641 114 µM -0.348447006533554 0.369377733714106 no 2142 0.363752252800925 2990 2835990 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.348480501980874 0.369364327960395 no 2143 0.363739677212585 3054 97141 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.349913180204445 0.3687910815725 no 2144 0.363201927609525 3068 688761 SGTC_509 pifithrin 175 µM -0.350387761408231 0.368601255365121 no 2145 0.363023854975862 3119 4817 A p53 inhibitor. SGTC_1077 5-fluorocytosine 377 nM -0.351751921717322 0.368055787943975 no 2146 0.362512158953633 3085 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_641 4092-0595 30 µM -0.351926027564372 0.367986189822639 no 2147 0.362446869562192 3102 786260 SGTC_923 1900-2434 73.3 µM -0.352358471734648 0.367813340734825 no 2148 0.362284721057663 2979 5910570 SGTC_43 0570-0105 72.5 µM -0.353679248740258 0.367285588493859 no 2149 0.361789637907624 3019 1114046 YDL195W SEC31 SGTC_456 gingerol 170 µM -0.354163846909988 0.367092016955123 no 2150 0.361608047933016 3213 442793 A herb. SGTC_3150 9097574 49.47 µM -0.355737589736137 0.366463622492891 no 2151 0.361018545765238 3197 17217476 SGTC_1208 2323-2347 50.3 µM -0.359098230854371 0.365122920540006 no 2152 0.359760802520075 3203 5412760 SGTC_397 arbidol 50 µM -0.359367613389857 0.365015523534628 no 2153 0.359660049744213 3181 131410 A RNA synthesis inhibitor. SGTC_3017 9080681 49.47 µM -0.360123113180733 0.364714378579343 no 2154 0.359377534478288 3101 16451914 SGTC_211 3455-0679 143.504 µM -0.363472673796513 0.363380239092464 no 2155 0.358125911138743 3132 748649 SGTC_3321 9137793 26.8275 µM -0.363796043434376 0.36325152742205 no 2156 0.358005158692845 3119 4904192 SGTC_2627 acetyl isogambogic acid 100 µM -0.363860257840779 0.363225969829383 no 2157 0.357981181487797 3130 6857789 A caspase activator and apoptosis inducer. SGTC_74 000s-0487 160.283 µM -0.363895229764787 0.363212051118737 no 2158 0.357968123454419 3095 677548 SGTC_2335 9018011 154.17 µM -0.365014932888287 0.362766508527064 no 2159 0.357550129683965 3131 6458208 SGTC_2836 9010338 19.48 µM -0.366826727632465 0.362045968438454 no 2160 0.356874134787997 3037 2994051 SGTC_196 k015-0023 18.111 µM -0.368194248643146 0.361502436831059 no 2161 0.356364199251639 3053 5211998 SGTC_382 3229-0966 23.2 µM -0.368710320884315 0.361297392548698 no 2162 0.356171827506612 3219 5722370 SGTC_2746 daunorubicin 9.88 µM -0.369656757987592 0.360921460542945 no 2163 0.355819127552123 3103 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1169 aniline yellow 25.8 µM -0.369706781453863 0.360901594576445 no 2164 0.355800489200334 3068 6051 A DNA damaging agent. SGTC_890 0929-0006 47.2 µM -0.369904133452114 0.360823223257235 no 2165 0.355726960754118 3062 1378169 SGTC_165 k038-0023 64.381 µM -0.371166342750034 0.360322120114011 no 2166 0.355256820010796 3062 46368543 SGTC_1874 staurosporine 7.6 µM -0.371301878339075 0.360268326080414 no 2167 0.355206349544504 3172 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1681 tripelennamine 100 µM -0.371405612599991 0.360227155852943 no 2168 0.355167722907749 3144 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1873 rapamycin 2 nM -0.371671081623782 0.360121803444197 no 2169 0.355068879263045 3076 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2958 9077254 16.72 µM -0.372048446096078 0.359972063178115 no 2170 0.354928389712855 3268 16457351 SGTC_1132 3456-3614 2.5 µM -0.372560177057563 0.359769039888537 no 2171 0.354737908184038 3288 3125502 SGTC_907 3448-6986 75.5 µM -0.372828347754984 0.359662662087905 no 2172 0.354638101548843 3239 590582 SGTC_1682 st012968 530 nM -0.37320957862977 0.359511454355963 no 2173 0.354496233832226 3052 24207270 SGTC_2144 5628481 200 µM -0.37400122988816 0.359197531727559 no 2174 0.354201700579321 3080 2818399 SGTC_1053 3366-3204 134 µM -0.376088694442656 0.358370221442847 no 2175 0.353425479461184 3098 3632071 YPR165W RHO1 SGTC_2026 5148700 152 µM -0.376146885120187 0.358347168637602 no 2176 0.353403850043178 3043 79838 SGTC_1497 4476-2978 41.3 µM -0.376612931066495 0.358162558615956 no 2177 0.353230638304707 3137 1528379 SGTC_412 gemfibrozil 100 µM -0.376658190839719 0.358144632089796 no 2178 0.353213818569301 3137 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_2520 obtusaquinone 4.71 µM -0.377230921069472 0.357917811684609 no 2179 0.353001001565668 3224 5967872 SGTC_82 0054-0107 293.755 µM -0.37752586060891 0.357801025280037 no 2180 0.352891424880751 3123 3104697 SGTC_3023 9089636 49.47 µM -0.378808763477972 0.357293192714411 no 2181 0.352414939612653 3177 17249241 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.380177257116405 0.356751757839467 no 2182 0.351906920125454 3080 2346 DNA damaging agent; causes G2/M arrest. SGTC_341 1486-1430 230 µM -0.381346991584078 0.356289189245324 no 2183 0.351472894502377 3021 2054753 YPL210C SRP72 SGTC_296 1222-0039 74.9 µM -0.381512687812868 0.356223682158979 no 2184 0.351411429172782 3102 5984176 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.38202448175557 0.356021374057729 no 2185 0.351221602782389 3154 4213774 SGTC_2180 6301957 200 µM -0.382050644121728 0.356011033369567 no 2186 0.351211900054331 3209 845462 SGTC_530 4358-1714 28 µM -0.384541490774738 0.355027011068162 no 2187 0.350288575076165 3137 1564641 SGTC_337 1315-0038 354 µM -0.384698090605021 0.35496517768084 no 2188 0.350230555006812 3099 1626437 SGTC_616 4092-0450 108 µM -0.384858764449447 0.354901739640594 no 2189 0.350171029152408 3126 787165 SGTC_2488 5268135 45.7 µM -0.384891469200533 0.354888827482043 no 2190 0.350158913267433 3204 1270356 YLR208W SEC13 SGTC_2626 ethyl orsellinate 100 µM -0.38763870004018 0.35380479000671 no 2191 0.349141712734597 3044 75653 A natural product. SGTC_2464 5717415 7.67 µM -0.389299775066545 0.35314991566122 no 2192 0.348527201339266 3086 5285744 SGTC_1250 0485-0349 40.2 µM -0.389339604221765 0.353134218452769 no 2193 0.348512471493736 3102 6842794 YDL195W SEC31 SGTC_128 0906-2981 13.371 µM -0.389917123724143 0.352906638304653 no 2194 0.348298915612724 3254 6740226 SGTC_1866 st057638 64 µM -0.390667733769961 0.352610927895449 no 2195 0.348021425964927 3103 688802 SGTC_2015 5119600 184 µM -0.391688325136692 0.35220899848586 no 2196 0.347644258680518 3251 2828786 SGTC_2974 9094440 9.66 µM -0.39184900856002 0.352145733146354 no 2197 0.347584890628537 3246 25236134 SGTC_2826 7992541 19.48 µM -0.391863126610358 0.352140174689792 no 2198 0.347579674580561 3093 2985066 SGTC_1047 2043-3044 82 µM -0.392168854263767 0.35201981356232 no 2199 0.347466727671247 3104 669592 SGTC_525 k781-2675 26.7 µM -0.392912971692446 0.351726925873301 no 2200 0.347191880247839 3194 3651118 YDL195W SEC31 SGTC_1055 3448-0672 86 µM -0.393234895893635 0.351600242434322 no 2201 0.347072999125457 3241 748378 SGTC_262 fenpropimorph 62.5 µM -0.393407544653368 0.351532308574803 no 2202 0.347009249078878 3143 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_95 0471-0001 561.058 µM -0.393505397066477 0.351493807697955 no 2203 0.34697311928558 3108 4015405 SGTC_460 trequinsin 123 µM -0.393630899742764 0.351444429816415 no 2204 0.346926782293558 3181 5537 A vasodilator. SGTC_1199 1638-0010 4.46 µM -0.394285293278216 0.3511870052883 no 2205 0.346685209978991 3101 3111136 SGTC_2098 5376439 882.5 nM -0.395510842602834 0.350705083908602 no 2206 0.346232960658093 3195 2844116 SGTC_2663 amphotericin b 100 µM -0.395713969031631 0.350625231910137 no 2207 0.346158024579504 3163 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1951 sophoraflavanone G 9.2 µM -0.396155095128454 0.35045184145992 no 2208 0.345995307960916 3096 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2014 4013930 200 µM -0.396268752444011 0.350407171994488 no 2209 0.34595338819569 3204 64556 SGTC_34 0469-0683 81.75 µM -0.397887468649159 0.349771210858795 no 2210 0.345356568822587 3171 3690923 SGTC_513 4245-1575 41.7 µM -0.398628112936505 0.34948036693642 no 2211 0.345083621920185 3174 719745 SGTC_1204 4049-0315 18.3 µM -0.399003435953572 0.349333014896296 no 2212 0.344945336268584 3316 588402 SGTC_2299 7976368 114.88 µM -0.400556132408485 0.348723666822068 no 2213 0.3443734742184 3236 2979718 SGTC_3295 9122362 53.5725 µM -0.402611155640848 0.347917782964558 no 2214 0.343617150835567 3202 4730473 SGTC_804 1595-0054 20.9 µM -0.404350666144589 0.347236164699196 no 2215 0.342977436343 3112 761523 Stimulates phospholipase C. SGTC_2176 5809774 33.9695 µM -0.404938555192334 0.347005914931105 no 2216 0.342761338547954 3219 2870539 SGTC_594 1487-1584 10.8 µM -0.405531670577814 0.346773675469881 no 2217 0.342543371768036 3124 5013332 SGTC_2838 9002687 71.43 µM -0.407648857231387 0.345945142704751 no 2218 0.341765744806187 3077 6457060 SGTC_860 0443-0016 25.1 µM -0.408089537892589 0.345772780747687 no 2219 0.341603970319526 3162 5337942 SGTC_1518 st038567 90.8 µM -0.408254729018154 0.345708178327573 no 2220 0.341543335921218 3200 77966 SGTC_2512 diallyl trisulfide 49.23 µM -0.408766272852059 0.345508153895166 no 2221 0.341355596616864 3176 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1085 doxorubicin 7.67 µM -0.410113473810289 0.344981576389464 no 2222 0.340861354627789 3234 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1109 tnp00067 928.257 nM -0.41013214698127 0.344974279753946 no 2223 0.340854505995998 3162 676295 SGTC_1633 st005664 67.9 µM -0.410177884282829 0.344956407916758 no 2224 0.340837731458862 3078 2063822 SGTC_2873 9040596 71.43 µM -0.41126143343376 0.344533112642079 no 2225 0.340440422866251 3234 6463863 SGTC_2089 5281248 129.67 µM -0.411355127493292 0.344496519603952 no 2226 0.340406076061152 3149 2737878 SGTC_553 k007-0256 45.7 µM -0.412251024399718 0.344146692727006 no 2227 0.340077720877689 3168 6287000 SGTC_1675 st018485 24.5 µM -0.412397492533113 0.344089513005257 no 2228 0.34002405036685 3148 3323024 SGTC_1545 lovastatin 49.4 µM -0.412518310694256 0.344042349463832 no 2229 0.339979781248964 3202 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_471 1-acyl-paf 4 µM -0.413609494678749 0.343616496161641 no 2230 0.339580059314387 3134 16759367 SGTC_1136 pergolide 1.05886 µM -0.41434813362299 0.343328342183324 no 2231 0.3393095838345 3082 47811 A dopamine receptor agonist. SGTC_490 phenamil 164 µM -0.414708172623589 0.343187918640417 no 2232 0.339177774422858 3175 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1385 3091-4834 14.1 µM -0.414933748711064 0.34309994977578 no 2233 0.339095201586473 3219 4072814 SGTC_3167 9103034 49.47 µM -0.418011799104474 0.341900440741441 no 2234 0.337969245237842 3204 5127859 SGTC_1547 harmine 94.2 µM -0.418123464553751 0.341856954871674 no 2235 0.337928424977504 3169 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1860 st056228 74.6 µM -0.418853476563779 0.341572718051402 no 2236 0.337661609817352 3241 688679 SGTC_1224 0823-0416 294 µM -0.420051888173213 0.341106300390191 no 2237 0.337223774241951 3270 3598164 SGTC_3078 9116413 49.47 µM -0.421487926376836 0.340547718949046 no 2238 0.336699412867723 3075 17177322 SGTC_1347 1493-0251 600 nM -0.422277034933913 0.340240925015947 no 2239 0.336411409281768 3262 3986378 SGTC_2267 7931562 200 µM -0.424051370052819 0.339551475698323 no 2240 0.335764174931969 3090 934880 SGTC_942 3253-1115 227 µM -0.424145132951711 0.339515057371725 no 2241 0.335729986031401 3320 46497897 SGTC_2470 5664817 21.68 µM -0.42560644865503 0.338947663486821 no 2242 0.335197320263358 3214 2859561 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.427189009699904 0.338333604796204 no 2243 0.334620832797361 3224 6708739 YPR165W RHO1 SGTC_3340 9146634 11.102 µM -0.42793089005998 0.338045891325584 no 2244 0.334350718367622 3241 4907387 SGTC_779 1360-0071 233 µM -0.428038896027472 0.338004012707972 no 2245 0.334311401154645 3343 7566 SGTC_2589 lobaric acid 100 µM -0.428303701275478 0.337901344664301 no 2246 0.334215012280981 3135 73157 A novel microtubule depolymerizer. SGTC_276 colchicine 750 µM -0.430903085795867 0.336894174510549 no 2247 0.333269419821392 3300 2833 A microtubule depolymerizer. SGTC_926 2268-1401 59.4 µM -0.431057813560746 0.336834259713951 no 2248 0.333213166976871 3236 2931578 SGTC_1835 st008666 49.2 µM -0.43135327040315 0.336719862295788 no 2249 0.333105761075205 3130 690455 SGTC_2808 7946468 45.46 µM -0.432008504054028 0.336466217436073 no 2250 0.332867616214017 3208 2970879 SGTC_1441 4106-0040 13 µM -0.43270885976025 0.336195187819345 no 2251 0.332613146254187 3212 2904180 SGTC_1809 st050081 57.6 µM -0.433199902784481 0.336005210561215 no 2252 0.332434774753088 3317 5036894 SGTC_3131 9127911 49.47 µM -0.434334136509459 0.335566552549989 no 2253 0.332022909154404 3379 45595681 SGTC_1207 2099-0101 141 µM -0.435576016423901 0.335086519940092 no 2254 0.331572187476882 3255 5837381 SGTC_1834 st055981 52.8 µM -0.437160571886844 0.334474421511898 no 2255 0.330997450836021 3335 471719 YDL150W RPC53 SGTC_407 eburnamonine 100 µM -0.438033650627231 0.334137347438767 no 2256 0.330680945034337 3143 3195 SGTC_2346 9031566 143.75 µM -0.438567288072814 0.33393138907119 no 2257 0.330487552017693 3213 4771086 SGTC_892 0929-0076 29 µM -0.439566127618004 0.333546019537405 no 2258 0.330125688978091 3205 5751038 SGTC_1410 3909-8106 77.9 µM -0.440264155923815 0.333276812366309 no 2259 0.3298728991463 3270 1039210 SGTC_2867 9039098 71.43 µM -0.440826275540866 0.333060083232644 no 2260 0.329669384885187 3152 6463460 SGTC_2123 5259487 200 µM -0.441204546487862 0.332914269608291 no 2261 0.329532461040173 3277 2173474 SGTC_141 0443-0274 32.331 µM -0.441241585744135 0.332899993294719 no 2262 0.329519055059849 3342 1627241 SGTC_1198 1612-1005 86.7 µM -0.443147721719503 0.332165624654821 no 2263 0.328829444721198 3356 6998509 SGTC_2094 5332512 191.667 µM -0.443641587802956 0.331975459975374 no 2264 0.328650866549328 3310 755774 SGTC_612 0302-0167 22.4 µM -0.443999553882255 0.331837651063377 no 2265 0.328521453225328 3230 235821 SGTC_1985 st071382 65.5 µM -0.446129387244174 0.331018183879004 no 2266 0.327751893054023 3215 6123237 SGTC_1849 st056239 19.2 µM -0.447523460021269 0.330482243045973 no 2267 0.327248576515757 3162 5393181 SGTC_1214 0358-0031 63.7 µM -0.448014216361446 0.330293658079456 no 2268 0.327071468333514 3384 4301366 SGTC_3326 9140064 16.379 µM -0.448772706685613 0.330002274659942 no 2269 0.326797814714727 3151 1868434 SGTC_902 1120-0002 2.07 µM -0.449275587239748 0.329809143715323 no 2270 0.326616433170622 3227 3280475 SGTC_2728 chlorpromazine 9.18 µM -0.449653214542408 0.329664146018961 no 2271 0.326480255548904 3204 2726 A thorazine and dopamine antagonist. SGTC_2277 7947813 106.88 µM -0.450553079118397 0.329318727896793 no 2272 0.326155845175356 3367 1246798 SGTC_2043 5101342 149 µM -0.450642559229325 0.329284388404065 no 2273 0.326123593865905 3210 678451 SGTC_1396 3511-0007 98.6 µM -0.450742052530128 0.329246207872638 no 2274 0.326087735030107 3263 X1396 SGTC_18 0111-0177 500 nM -0.451347259263572 0.329013998300047 no 2275 0.325869644354019 3244 721752 SGTC_1913 st060213 96.1 µM -0.45199312416001 0.328766261508839 no 2276 0.325636967914892 3357 688959 SGTC_17 0960-0276 49.807 µM -0.452906950324453 0.328415870349694 no 2277 0.325307872974317 3211 6821114 SGTC_747 3448-8087 38.7 µM -0.453792579228724 0.328076434888047 no 2278 0.324989062610525 3219 5168703 SGTC_956 1185-0240 191 µM -0.454000214429344 0.327996874962715 no 2279 0.324914336229264 3189 1416193 SGTC_1653 st012112 65 µM -0.454381333430916 0.327850861271841 no 2280 0.324777192636558 3332 720429 SGTC_2366 9070441 60.58 µM -0.454887164415156 0.327657108768719 no 2281 0.324595208795372 3195 6837235 SGTC_839 0122-0028 230 µM -0.454977496280436 0.327622513110198 no 2282 0.324562714321685 3206 759448 SGTC_1733 st037357 54.9 µM -0.4557784522556 0.32731582455446 no 2283 0.32427465026366 3099 1272339 YGL099W LSG1 SGTC_3212 9128307 49.47 µM -0.456423799136047 0.327068803965378 no 2284 0.324042627541783 3074 27243542 SGTC_197 4544-0043 41.561 µM -0.456551260969656 0.327020024123193 no 2285 0.323996809038596 3264 896523 SGTC_3267 9137951 49.47 µM -0.45693930516268 0.326871537202627 no 2286 0.323857335824704 3148 16643986 SGTC_3172 9105863 49.47 µM -0.460706409393028 0.325431464876926 no 2287 0.322504627985327 3255 2348785 SGTC_2947 9072639 7.68 µM -0.463354858864901 0.324420583408415 no 2288 0.321555014801961 3303 16488146 SGTC_3273 9137859 49.47 µM -0.464722576541804 0.323899047511475 no 2289 0.321065069311861 3308 2377234 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.466602432053232 0.323182787980051 no 2290 0.320392173325981 3312 66535 A nucleotide analog. SGTC_2963 9082507 9 µM -0.467527971891861 0.322830380735861 no 2291 0.320061092125472 3337 16459611 SGTC_2813 7971799 71.43 µM -0.468773789097926 0.322356276268793 no 2292 0.319615668508845 3304 2234054 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.469650411483838 0.322022844527696 no 2293 0.319302400911413 3291 165521 SGTC_1652 st011932 78 µM -0.470513032109708 0.321694878283663 no 2294 0.31899426282184 3298 1551076 SGTC_3333 9141820 12.094 µM -0.471526861691396 0.321309600318178 no 2295 0.318632270991695 3208 1939433 SGTC_1635 st007035 42.4 µM -0.471549645654324 0.321300944108384 no 2296 0.318624137874959 3311 3716403 SGTC_527 4476-4215 268 µM -0.47207201237622 0.321102510273603 no 2297 0.318437694308168 3213 4418754 SGTC_379 3970-0972 5.9 µM -0.472647103656168 0.32088410678605 no 2298 0.318232485414053 3291 2898042 YBL034C STU1 SGTC_2289 7946404 165.07 µM -0.47290102632036 0.320787693818845 no 2299 0.318141896344974 3210 1246120 YPR165W RHO1 SGTC_2032 5185112 25.99 µM -0.474356019356316 0.320235474580682 no 2300 0.317623025082683 3242 5718189 SGTC_2888 9058547 12.99 µM -0.474819957865866 0.320059477775938 no 2301 0.317457653228273 3216 16476514 SGTC_149 3970-0822 46.1 µM -0.476251008050007 0.319516858722186 no 2302 0.316947781974021 3371 3114250 YBL034C STU1 SGTC_964 1287-0107 19.4 µM -0.477653321035617 0.318985510704998 no 2303 0.316448486523985 3365 51516812 YPR165W RHO1 SGTC_3202 9113761 49.47 µM -0.479200487809656 0.318399707722166 no 2304 0.315898003626731 3342 4798415 SGTC_816 0325-0417 81.3 µM -0.479429740998468 0.318312944267398 no 2305 0.315816469880686 3318 68101 SGTC_1701 st028638 40.4 µM -0.479842628774678 0.318156707371438 no 2306 0.315669649218901 3363 3490878 SGTC_2260 7964312 200 µM -0.480914700462479 0.317751186125102 no 2307 0.315288562174667 3372 231951 SGTC_2078 5212016 200 µM -0.480984619933256 0.317724746009955 no 2308 0.315263714868543 3287 1899708 SGTC_1153 4055-0057 267 µM -0.482118289026453 0.317296177744765 no 2309 0.314860959174136 3241 882706 SGTC_208 k072-0098 12.366 µM -0.482350016909209 0.317208606275375 no 2310 0.314778660883296 3301 5948901 SGTC_1669 st015249 58.4 µM -0.483361979601207 0.316826298995203 no 2311 0.314419369590473 3364 722793 SGTC_158 k038-0087 26.446 µM -0.483550205845651 0.316755210947913 no 2312 0.314352560361047 3195 X158 SGTC_2142 5622915 118.518 µM -0.485739782537273 0.315928763767153 no 2313 0.313575836853118 3282 5322196 SGTC_1154 4088-0362 150 µM -0.487460597153101 0.315279893781725 no 2314 0.312965979811445 3308 6618304 SGTC_258 haloperidol 50.781 µM -0.488636501582086 0.314836821177512 no 2315 0.312549533067846 3294 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.488795384309201 0.314776975686692 no 2316 0.312493283059227 3370 368090 SGTC_2665 lovastatin 100 µM -0.489699647587373 0.314436464426667 no 2317 0.312173225635175 3318 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1315 1237-0019 3.69 µM -0.490743604156163 0.314043546234111 no 2318 0.311803901018292 3359 825140 SGTC_1049 3226-0134 66 µM -0.490866478224944 0.313997313470889 no 2319 0.311760443812806 3338 5702385 SGTC_1349 flufenamic acid 69 µM -0.490901499781175 0.313984136747387 no 2320 0.311748058123899 3271 3371 A non-steroidal anti-inflammatory. SGTC_16 erodoxin 22.806 µM -0.49102149382022 0.31393899125823 no 2321 0.31170562276557 3389 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2022 5136654 200 µM -0.49179822137961 0.313646829575518 no 2322 0.311430997010236 3348 1713771 SGTC_7 0192-1582 4.227 µM -0.492059828610772 0.313548453788777 no 2323 0.311338524756207 3320 252616 SGTC_1155 4088-0394 48.2 µM -0.492191068872254 0.313499106691554 no 2324 0.311292138767872 3245 2326248 SGTC_2343 7990716 14.84 µM -0.492312977865878 0.31345327119525 no 2325 0.311249053537675 3240 6456862 SGTC_2790 5423970 71.43 µM -0.492365187107924 0.31343364237992 no 2326 0.31123060247234 3384 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2495 cafestol 54.53 µM -0.493061857074593 0.313171769872102 no 2327 0.310984440452301 3403 16667697 An anti-infammatory. SGTC_2262 9014885 67.46 µM -0.493527448768628 0.312996810287982 no 2328 0.310819974970741 3285 6457424 SGTC_2669 eugenol 100 µM -0.493747580751727 0.312914103966794 no 2329 0.310742228764392 3313 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_517 1365-0151 113 µM -0.495362288446117 0.312307726259451 no 2330 0.310172204848217 3402 768657 SGTC_422 cantharidin 155 µM -0.495594480080096 0.312220572135345 no 2331 0.310090274039929 3241 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1320 1313-0481 95.3 µM -0.496115857338635 0.31202490923913 no 2332 0.309906335961906 3424 6813365 YLR208W SEC13 SGTC_1900 st060200 72.8 µM -0.497368117395167 0.311555176728111 no 2333 0.309464742204061 3255 688945 SGTC_2199 6590217 200 µM -0.497547976102495 0.311487735482123 no 2334 0.30940133986243 3289 703109 SGTC_3153 9100258 49.47 µM -0.497610632125591 0.311464242968548 no 2335 0.309379254198651 3254 25236848 SGTC_1244 0416-0015 52.5 µM -0.498026443401117 0.311308356389352 no 2336 0.309232702053338 3271 96201 SGTC_1942 st076330 65.2 µM -0.499010627940556 0.310939522972504 no 2337 0.308885948436156 3418 24208414 SGTC_647 0140-0236 81 µM -0.501161016603477 0.310134303315935 no 2338 0.308128903747396 3311 990837 SGTC_740 k014-0057 261 µM -0.501512353192709 0.310002830591992 no 2339 0.30800529306916 3341 4012779 SGTC_580 1123-0028 41 µM -0.501804066272903 0.309893687876998 no 2340 0.307902676265102 3377 1677248 YPR107C YTH1 SGTC_1477 0139-0234 16 µM -0.502345621849342 0.309691112501985 no 2341 0.307712211431208 3347 620880 SGTC_3111 9122088 49.47 µM -0.50300110511584 0.309445998410933 no 2342 0.307481747591324 3261 16876704 SGTC_251 melphalan 456.522 µM -0.504020125349754 0.309065110138243 no 2343 0.3071236173029 3342 460612 A DNA alkylator. SGTC_1192 1488-0095 21.4 µM -0.506612655573622 0.30809700270624 no 2344 0.306213313376096 3363 915875 SGTC_2658 polymyxin b sulfate 77.05 µM -0.506782639114155 0.308033573657188 no 2345 0.306153669479386 3328 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_172 1112-0046 2.638 µM -0.507451319206279 0.307784112553001 no 2346 0.305919092595951 3250 2802135 YIL048W NEO1 SGTC_2582 agaric acid 100 µM -0.507868168923266 0.307628645473048 no 2347 0.305772899544356 3374 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1487 3970-0795 2.82 µM -0.508487643095512 0.307397671967111 no 2348 0.305555701394087 3381 3765103 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.509147992003045 0.307151542227619 no 2349 0.305324247194796 3444 688664 SGTC_1902 st060212 70.5 µM -0.509431980381671 0.307045718848878 no 2350 0.305224732368976 3421 688944 SGTC_2394 5221648 200 µM -0.510039879745296 0.306819249648048 no 2351 0.305011761488686 3393 788586 SGTC_2869 9037858 32.47 µM -0.511333683672736 0.30633749634826 no 2352 0.304558711323207 3334 27187042 SGTC_2664 lyso-paf C-16 73.48 µM -0.511907137072397 0.306124075542157 no 2353 0.304358001457366 3295 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_982 1491-0518 27.5 µM -0.512146276380048 0.306035095059931 no 2354 0.304274319612214 3284 3091256 SGTC_2416 tofa 880 nM -0.513206086077901 0.305640892093687 no 2355 0.303903584568509 3254 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1031 k035-0009 16 µM -0.514542710272289 0.305144047280847 no 2356 0.303436303741382 3427 5180959 SGTC_2812 7970281 58.44 µM -0.514679475086093 0.305093229814092 no 2357 0.303388509175864 3422 2233435 SGTC_3291 9121177 71.43 µM -0.518538821931753 0.303660771068159 no 2358 0.302041190483202 3317 17015612 SGTC_505 gw-5074 63.9 µM -0.519972433528411 0.303129428816868 no 2359 0.301541394324771 3403 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2293 7624732 200 µM -0.520620709315688 0.30288929371781 no 2360 0.301315509917456 3362 894453 SGTC_2082 5219693 150 µM -0.52090751135024 0.302783083341069 no 2361 0.301215601290518 3359 2834649 SGTC_562 3772-2733 112 µM -0.521044192891683 0.302732472421498 no 2362 0.301167992984036 3411 2876874 YIL048W NEO1 SGTC_3036 9090181 49.47 µM -0.521763681157204 0.30246612028641 no 2363 0.300917439943871 3383 25236586 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.522720904423306 0.302111922439787 no 2364 0.300584244380499 3347 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2655 perillic acid 100 µM -0.522963037323138 0.302022356401431 no 2365 0.300499987827211 3322 5702197 An apoptosis inducer. SGTC_628 1636-0253 16 µM -0.52360555338349 0.301784744677665 no 2366 0.300276459077343 3370 4456143 SGTC_1195 1502-0147 41.1 µM -0.523692981793826 0.301752418884145 no 2367 0.30024604889555 3376 817940 SGTC_144 4161-2749 112.381 µM -0.524285099856558 0.301533530047257 no 2368 0.30004012941031 3336 797501 YMR168C CEP3 SGTC_2638 epoxomicin 18 µM -0.524975790563636 0.30127829207775 no 2369 0.299800010317089 3387 9915668 A protesome inhibitor. SGTC_1318 1280-3875 124 µM -0.525285300977738 0.301163947121418 no 2370 0.299692437051202 3383 373245 SGTC_1038 k292-0204 154 µM -0.526608149084677 0.30067545707928 no 2371 0.299232865896059 3355 4454212 SGTC_977 1348-1378 135 µM -0.527395188256992 0.300384995765889 no 2372 0.298959592132356 3338 X977 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.527682868421945 0.300278857402726 no 2373 0.298859732844286 3441 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1843 st055809 45.5 µM -0.52940450483654 0.29964402163235 no 2374 0.298262436914833 3406 16413835 SGTC_391 gliotoxin 8.33 µM -0.530844973451707 0.299113331298967 no 2375 0.297763105990014 3474 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_840 0245-0196 390 µM -0.53205054788917 0.298669507761312 no 2376 0.297345493265743 3474 3827528 SGTC_2939 9044578 71.43 µM -0.532059417394513 0.29866624362665 no 2377 0.297342421848057 3350 2653634 SGTC_2524 avocatin b 10.57 µM -0.532336767278422 0.298564182154186 no 2378 0.297246385774445 3366 6710748 SGTC_3192 9110362 49.47 µM -0.532553422741076 0.298484466547689 no 2379 0.297171375811959 3461 16649480 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.533112140553709 0.298278938174095 no 2380 0.296977977740901 3303 688803 SGTC_2933 9026794 32.47 µM -0.533627583590769 0.298089385902269 no 2381 0.296799610147738 3313 17586027 SGTC_373 0844-0104 25.9 µM -0.533749626692141 0.298044513039993 no 2382 0.296757384661628 3420 5375804 SGTC_1932 st074806 40.9 µM -0.534268074553208 0.297853924220306 no 2383 0.296578038429031 3531 17251235 SGTC_2222 6885208 172.143 µM -0.534287588134882 0.297846751835078 no 2384 0.296571289081856 3380 609514 SGTC_2459 5811157 9.22 µM -0.534917051231467 0.297615429506546 no 2385 0.296353608479139 3410 2870684 YBR192W RIM2 SGTC_1945 st075991 56.6 µM -0.536403419087775 0.297069527654884 no 2386 0.295839884456658 3343 1084980 SGTC_921 1561-0023 372 µM -0.537937262273017 0.296506669996502 no 2387 0.29531018109215 3407 24050882 SGTC_2925 9010536 32.5 µM -0.538254026083506 0.296390491553503 no 2388 0.29520084304625 3363 2994177 SGTC_1418 3966-3099 2.4 µM -0.539388044932514 0.295974742294067 no 2389 0.294809564194955 3437 740335 SGTC_215 1287-0124 461.5 µM -0.539473934510016 0.295943264725368 no 2390 0.29477993882584 3375 5560863 SGTC_1495 4469-0029 237 µM -0.541441481245327 0.295222602188681 no 2391 0.294101661106736 3426 793680 SGTC_979 1426-2828 121 µM -0.541745730470873 0.295111235560533 no 2392 0.293996840871923 3462 747872 SGTC_1403 3909-7815 62.9 µM -0.542033173945528 0.295006038244192 no 2393 0.293897826441024 3347 6615483 SGTC_1238 0333-0287 48.8 µM -0.542801318753558 0.294725000741937 no 2394 0.293633302573829 3382 7226 SGTC_1359 1582-0056 520 nM -0.544050712911472 0.294268154733788 no 2395 0.293203287809926 3445 3661189 SGTC_2391 6285546 200 µM -0.545104598422742 0.293883051756743 no 2396 0.292840790112323 3331 846083 SGTC_1174 0739-0097 51.1 µM -0.545363863983443 0.293788348608965 no 2397 0.292751644230568 3387 728447 SGTC_1983 st071813 46.9 µM -0.546134977309213 0.293506763910873 no 2398 0.292486579097081 3401 11838595 SGTC_1236 0330-0013 258 µM -0.546396368894462 0.293411340854301 no 2399 0.292396752781263 3358 4617066 SGTC_2531 methyl deoxycholate 70.07 µM -0.547682179364629 0.292942154995791 no 2400 0.291955075293788 3312 16667744 Haematoxylin. SGTC_692 k241-0027 77.8 µM -0.548466914887757 0.29265598008914 no 2401 0.291685670423513 3508 3600480 SGTC_1848 st056003 16.4 µM -0.548787597921514 0.292539071788491 no 2402 0.291575611187277 3472 146492 SGTC_2878 9043973 25.97 µM -0.549710948444898 0.29220257611908 no 2403 0.291258823121629 3475 6465167 SGTC_662 k832-1615 104 µM -0.549755910444659 0.292186195263322 no 2404 0.291243401419782 3410 5878478 SGTC_1773 st048542 73.5835 µM -0.551530252661202 0.291540096482558 no 2405 0.290635117026472 3330 3237138 SGTC_914 3820-6779 408 µM -0.551734859759975 0.291465634893018 no 2406 0.29056501134942 3362 2893481 SGTC_2147 5545932 89.7195 µM -0.554593415236951 0.290426264734526 no 2407 0.289586396994837 3424 797404 SGTC_1581 himbacine 57.9 µM -0.554645693738403 0.290407272449501 no 2408 0.289568514089167 3374 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1380 2291-0730 164 µM -0.555059914870064 0.290256810390429 no 2409 0.289426839810539 3382 2999191 SGTC_2729 fluphenazine 10.66 µM -0.557286691880081 0.28944858035319 no 2410 0.288665783398125 3362 3372 An atypical antipsychotic. SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.558608231817581 0.288969415174057 no 2411 0.288214560392506 3451 16486 A toxic proline analog. SGTC_872 0588-0139 234 µM -0.558673510343958 0.288945756101179 no 2412 0.288192280495513 3448 2047100 SGTC_969 1313-0238 134 µM -0.559412985190957 0.28867780989613 no 2413 0.287939950675146 3381 5212874 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.560250413846609 0.288374511835203 no 2414 0.287654322249916 3368 88881 An O-methylated flavonoid and antioxidant. SGTC_814 3342-0569 96 µM -0.560571762016352 0.288258166563161 no 2415 0.287544753046272 3508 4346283 SGTC_858 0438-0351 2.77 µM -0.560631682633156 0.288236474535368 no 2416 0.287524324260896 3414 2799119 SGTC_770 0389-1121 67.2 µM -0.561778868645757 0.287821327114139 no 2417 0.287133345583237 3535 6753108 SGTC_1162 k048-0130 20.1 µM -0.56252282905462 0.287552251348786 no 2418 0.286879927030073 3385 6797406 SGTC_2630 antimycin a 100 µM -0.563270111274061 0.287282093933554 no 2419 0.28662548369724 3418 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3257 9139206 32.98 µM -0.563515956358165 0.287193242299792 no 2420 0.286541798909968 3442 4910041 SGTC_555 4296-0685 37 µM -0.563813095866856 0.287085869554234 no 2421 0.286440669157522 3432 2908540 YHR072W ERG7 SGTC_2502 avocadyne acetate 18.59 µM -0.563942990040064 0.287038937661538 no 2422 0.286396465730994 3417 3952079 SGTC_764 1951-2361 146 µM -0.565205172677 0.286583089417978 no 2423 0.285967109380581 3352 5438930 SGTC_2421 5690543 90.72 µM -0.567194173793236 0.285865442070956 no 2424 0.2852911329835 3460 3397993 SGTC_455 paf C-16 10 µM -0.56749054864083 0.285758580871141 no 2425 0.285190473052381 3445 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2902 5787006 60.46 µM -0.567664130425899 0.285696002880154 no 2426 0.285131526076864 3388 591003 SGTC_3140 9094243 49.47 µM -0.569061686781411 0.285192407371243 no 2427 0.284657138934711 3518 19291112 SGTC_1845 st056753 3.01 µM -0.569244579894491 0.285126534975579 no 2428 0.284595085508819 3354 5375839 SGTC_2805 7950783 58.44 µM -0.570876359492049 0.284539140093018 no 2429 0.284041728489238 3457 1178958 YDL195W SEC31 SGTC_2055 5235184 200 µM -0.571166563961821 0.284434735187498 no 2430 0.283943370433311 3482 2836034 SGTC_2438 5259590 200 µM -0.571912277757395 0.284166538735667 no 2431 0.283690702863621 3442 1201127 SGTC_2399 5884133 200 µM -0.572539538228004 0.283941037780645 no 2432 0.28347825383615 3414 722445 SGTC_675 1309-0189 238 µM -0.5736638449648 0.283537062487223 no 2433 0.283097649423891 3419 4246530 SGTC_213 1246-0773 967 nM -0.574119930923101 0.28337326454291 no 2434 0.282943323491769 3424 6251622 SGTC_908 3448-7491 47.7 µM -0.574382808361555 0.283278875796791 no 2435 0.282854391934256 3491 1203031 SGTC_715 0868-0130 184 µM -0.575636772906634 0.282828835054119 no 2436 0.282430360012055 3540 2876258 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.577572439205627 0.282134810379866 no 2437 0.281776409412028 3529 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2063 5246145 200 µM -0.57762772586049 0.282114999641193 no 2438 0.281757741948392 3496 711240 SGTC_1623 st003709 20.3 µM -0.577798658192697 0.282053754092074 no 2439 0.281700030650408 3484 16192618 SGTC_2153 5569715 200 µM -0.578461892005152 0.281816176136095 no 2440 0.281476159260803 3479 2054701 SGTC_1579 chlormadinone acetate 49.4 µM -0.578524947012453 0.281793594130765 no 2441 0.281454879814901 3509 45114258 A steroidal progestin. SGTC_419 nsc-638432 893 µM -0.57929041514464 0.281519525204737 no 2442 0.281196615901275 3427 368090 SGTC_2827 7993847 71.43 µM -0.580132363288911 0.281218221882171 no 2443 0.28091268036548 3468 2985692 SGTC_1166 k206-0078 225 µM -0.580690863510964 0.281018440442642 no 2444 0.280724410261733 3486 5404595 SGTC_1004 4084-0029 199 µM -0.581331039494821 0.280789527107628 no 2445 0.280508682401731 3505 716894 YLR208W SEC13 SGTC_411 enrofloxacin 100 µM -0.585015616904711 0.279473756334873 no 2446 0.279268608012973 3570 71188 A bacterial gyrase inhibitor. SGTC_3238 9133470 49.47 µM -0.585114537472661 0.279438472893742 no 2447 0.279235352249874 3530 3534688 SGTC_146 3448-8650 53.125 µM -0.585635653619781 0.279252634528155 no 2448 0.279060191800724 3476 2891488 YIL048W NEO1 SGTC_2534 helenine 20.12 µM -0.586543463512342 0.27892903850268 no 2449 0.278755181378827 3480 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1991 st073000 8.92 µM -0.587006019756584 0.278764226851707 no 2450 0.278599831893791 3582 4301969 YIL048W NEO1 SGTC_546 peri-Naphthalide 147 µM -0.587396321839655 0.278625196688296 no 2451 0.278468781771043 3408 223824 A penicillin ester. SGTC_1331 1472-0049 76.2 µM -0.587427322036663 0.278614155503459 no 2452 0.278458374250208 3430 24051409 SGTC_1481 3346-2004 36 µM -0.587540347345319 0.278573901650314 no 2453 0.278420430507699 3503 2770522 SGTC_1627 st003713 25.6 µM -0.588682788870818 0.278167181311408 no 2454 0.278037042802137 3488 16195070 YER133W GLC7 SGTC_2679 rapamycin 1 nM -0.589189007592508 0.277987055139958 no 2455 0.27786724513313 3500 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1018 4259-0013 28.1 µM -0.589373830548762 0.277921304371717 no 2456 0.277805263782465 3491 6801262 SGTC_2017 5132927 60.65 µM -0.58974694194198 0.277788593123294 no 2457 0.27768015948678 3429 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1080 nisoldipine 24.4 µM -0.590809048995154 0.27741098388049 no 2458 0.277324185598623 3432 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_820 1582-0060 59.9 µM -0.591041038428797 0.277328538447789 no 2459 0.277246462142868 3424 3848840 SGTC_1534 6-azauridine 81.6 µM -0.591563446219913 0.277142926734246 no 2460 0.277071478800935 3479 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3191 9110352 49.47 µM -0.592052637096568 0.27696917213247 no 2461 0.27690767066578 3493 17122424 SGTC_289 k017-0060 526 µM -0.594563719469072 0.276078106884465 no 2462 0.276067568792145 3456 5512909 SGTC_2651 TUB2.036 5 µM -0.595273415103279 0.275826524569144 no 2463 0.275830361692839 3599 15992207 YFL037W TUB2 SGTC_2472 5377652 49.4 µM -0.597503402180571 0.275036743047929 no 2464 0.275085668109821 3480 1610903 SGTC_3141 9094609 49.47 µM -0.600100900889472 0.274118208774059 no 2465 0.274219496109051 3411 25236309 YDL196W YDL196W SGTC_1449 4112-4002 201 µM -0.600462792762514 0.273990356006853 no 2466 0.274098925229813 3483 2059539 SGTC_2992 9074591 71.4286 µM -0.60144358892012 0.27364399881074 no 2467 0.273772286839182 3528 17741321 SGTC_87 0100-0052 35.5 µM -0.601482577816193 0.273630234796204 no 2468 0.273759306193739 3588 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1806 st050005 60.3 µM -0.601570439834124 0.273599218654403 no 2469 0.273730055245194 3467 5194765 SGTC_1980 st071811 45.7 µM -0.601968082990573 0.27345886853282 no 2470 0.273597691556427 3579 4974850 SGTC_755 1995-0008 37.3 µM -0.603018940425428 0.273088134839579 no 2471 0.273248044604646 3532 689533 SGTC_577 r071-0003 38.6 µM -0.603323629540179 0.272980689677867 no 2472 0.273146708209687 3532 4568517 YMR134W ERG29 SGTC_1050 3232-1156 69.3 µM -0.604155620786572 0.272687404195097 no 2473 0.272870091563026 3448 700529 SGTC_1272 0839-0021 27 µM -0.60423699726594 0.272658726545417 no 2474 0.272843043344172 3513 5027250 SGTC_2662 daunorubicin 22.37 µM -0.606762560977116 0.271769444746526 no 2475 0.272004248731833 3449 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_100 0086-0128 49.5915 µM -0.60691028229169 0.271717474987118 no 2476 0.271955226998658 3504 93297 SGTC_3319 9138450 16.7555 µM -0.607259178857103 0.271594749508997 no 2477 0.271839462142387 3437 2029690 SGTC_273 hydroxyurea 18.1 mM -0.609116908344649 0.270941752361057 no 2478 0.271223475460236 3569 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_723 4182-0001 115 µM -0.609547081370937 0.270790657106704 no 2479 0.271080937801526 3462 744821 YLR208W SEC13 SGTC_1604 st002052 72.4 µM -0.611572244877407 0.270079898262535 no 2480 0.2704104030513 3576 6254834 YHR062C RPP1 SGTC_442 cape 100 µM -0.612086739590941 0.26989947809225 no 2481 0.270240185203152 3525 5281787 SGTC_263 alizarin 107.927 µM -0.613516760055221 0.269398323494362 no 2482 0.269767352111177 3549 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_233 rapamycin 362 pM -0.616479059428271 0.268361663904952 no 2483 0.268789194233688 3551 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_88 0180-0332 8.668 µM -0.61739156225264 0.268042737314472 no 2484 0.268488243060257 3569 3101745 SGTC_2508 celastrol 40.54 µM -0.617410274978247 0.268036199073464 no 2485 0.268482073217665 3508 122724 Celastrol is a natural product and antioxidant. SGTC_236 1509-0011 5.31 µM -0.617602964645247 0.267968877823111 no 2486 0.268418544934884 3616 3107280 SGTC_2388 9080168 200 µM -0.617648275816094 0.267953048399295 no 2487 0.268403607292487 3495 15943073 SGTC_1829 berberine 14.4 µM -0.621004804613593 0.266781758505717 no 2488 0.267298230970697 3583 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_409 arachidonic acid 100 µM -0.621127547539082 0.266738975386016 no 2489 0.267257852691352 3576 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.621780822239744 0.266511329137247 no 2490 0.267042999165776 3560 688669 SGTC_2374 9071832 200 µM -0.622092383142598 0.266402794311549 no 2491 0.266940561576366 3531 17381698 SGTC_1759 st043059 70 µM -0.623299013665836 0.265982665678227 no 2492 0.266544022921775 3488 669426 SGTC_338 4055-0136 114 µM -0.623573591685851 0.265887109090006 no 2493 0.266453829138817 3517 2900563 SGTC_2425 5628681 7.85 µM -0.625057134053016 0.265371118862239 no 2494 0.265966780217287 3547 5714958 SGTC_652 0437-0092 114 µM -0.626675536243791 0.264808803283951 no 2495 0.265435971510643 3556 3091274 SGTC_1398 3558-0053 112 µM -0.627324710130903 0.264583417463851 no 2496 0.265223204548878 3474 4532369 SGTC_113 0099-0221 2.5 µM -0.627579808539554 0.264494876902702 no 2497 0.265139619665469 3609 89219 SGTC_1766 st045414 44.774 µM -0.62782753536032 0.264408909333641 no 2498 0.265058462943434 3600 253960 SGTC_1223 0764-0573 147 µM -0.629257926244656 0.263912805256793 no 2499 0.264590105644171 3581 1609797 SGTC_1700 st030840 7.9285 µM -0.630592823361983 0.263450249800423 no 2500 0.264153396266026 3564 5499307 SGTC_1361 1608-0041 5.61 µM -0.630746681387125 0.263396963036373 no 2501 0.264103085476357 3552 X1361 SGTC_2011 4012611 177 µM -0.631056967096679 0.263289516280284 no 2502 0.264001638483397 3554 2049887 SGTC_2699 st077704 54.6 µM -0.633005596692613 0.262615250495864 no 2503 0.263364994098436 3557 645852 SGTC_694 1315-0438 43.2 µM -0.636401018700542 0.261442479780611 no 2504 0.262257538542996 3516 6793154 SGTC_557 1315-0110 16.2 µM -0.637474332025476 0.261072320118693 no 2505 0.2619079620697 3560 6833801 SGTC_972 1319-0219 195 µM -0.63830987151277 0.260784349482318 no 2506 0.261635993667387 3541 23903702 SGTC_1014 4130-3005 69.3 µM -0.639062452656071 0.260525110595897 no 2507 0.261391152361784 3586 743608 SGTC_1252 0493-0875 34.8 µM -0.641103153219144 0.259822826217359 no 2508 0.26072783283946 3576 3960963 SGTC_949 1165-0505 146 µM -0.641377079594961 0.259728631914991 no 2509 0.260638860423346 3574 6244267 SGTC_1096 rimcazole 32.2 µM -0.64295707953007 0.259185665923173 no 2510 0.260125975134547 3526 18528119 A dopamine reuptake inhibitor. SGTC_794 k038-0031 316 µM -0.643850360969222 0.25887895015284 no 2511 0.259836236584046 3629 6624242 SGTC_1176 0848-0131 83.3 µM -0.646551493835791 0.257952636988134 no 2512 0.258961129977327 3625 6769040 SGTC_441 propafenone 146 µM -0.647356424291527 0.257676931032804 no 2513 0.258700645669211 3571 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1687 st020778 55.3625 µM -0.647493939351246 0.257629844479852 no 2514 0.258656157859185 3594 4259299 SGTC_274 sirtinol 40.1 µM -0.647747780759763 0.25754293834075 no 2515 0.258574047451884 3586 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1704 st028805 70.8 µM -0.648815356446611 0.257177605693558 no 2516 0.258228865185188 3573 2876101 SGTC_2481 5478948 45.16 µM -0.648947224462878 0.257132498143805 no 2517 0.25818624450664 3609 77792 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.649917559131608 0.25680070631549 no 2518 0.257872737641046 3602 5106787 A p450 inhibitor. SGTC_1467 k284-1082 293 µM -0.651256064640911 0.256343389800164 no 2519 0.257440602311156 3582 3334705 SGTC_2897 9048598 12.99 µM -0.651526158771366 0.256251160383335 no 2520 0.257353448299338 3570 6467404 SGTC_3279 9140807 49.47 µM -0.651744079756394 0.256176759214174 no 2521 0.257283140703322 3620 45595718 SGTC_1078 idebenone 36.1 µM -0.652708956727105 0.255847472574481 no 2522 0.25697196356374 3607 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1825 st052143 62.6 µM -0.653150310745023 0.255696923951174 no 2523 0.256829690211351 3624 674173 SGTC_2859 9028643 45.46 µM -0.656537394000388 0.254543110053804 no 2524 0.255739207870765 3574 17151580 SGTC_351 caspofungin 25 nM -0.658141807445053 0.253997518275847 no 2525 0.255223506817075 3650 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2119 5528445 120.635 µM -0.658556340729935 0.253856653207397 no 2526 0.255090353265726 3618 791935 SGTC_3255 9139072 49.47 µM -0.659306239743895 0.253601929705234 no 2527 0.254849568178757 3628 17646060 SGTC_2029 5175081 200 µM -0.660131872964546 0.253321636389294 no 2528 0.254584603251778 3614 1380876 SGTC_2877 9040724 71.43 µM -0.661480797774269 0.252864042026192 no 2529 0.254152012543494 3611 6463895 SGTC_3338 9144300 39.5675 µM -0.662908831453433 0.2523800861855 no 2530 0.25369447261317 3585 4901274 SGTC_2291 7917025 104.35 µM -0.663536017012909 0.252167689499427 no 2531 0.253493660058205 3582 2964612 SGTC_2972 9093619 59.92 µM -0.664614613773496 0.251802642786982 no 2532 0.253148509884995 3606 25236256 SGTC_2122 5258151 111.688 µM -0.664955618754858 0.251687289105096 no 2533 0.253039439989045 3598 2173356 SGTC_2233 sulbentine 40.3845 µM -0.666012668879489 0.251329892204595 no 2534 0.252701501371408 3603 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_611 3453-1652 23.7 µM -0.668371560144123 0.250533301084217 no 2535 0.251948222381409 3621 1560575 SGTC_3054 9094397 49.47 µM -0.6693180121565 0.250214063287753 no 2536 0.251646319602479 3618 2598354 SGTC_637 1181-0519 7.26 µM -0.669949935418789 0.250001036044979 no 2537 0.251444852804293 3641 6252091 YGR060W ERG25 SGTC_139 0099-0334 718.624 µM -0.669953961053554 0.249999679274407 no 2538 0.251443569643679 3671 97690 SGTC_2414 st077232 92.9 µM -0.670892001058456 0.249683635672554 no 2539 0.251144666209955 3596 729801 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.672840789969912 0.249027730382412 no 2540 0.250524292198253 3651 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2766 oltipraz 83.91 µM -0.673036994725754 0.248961744440317 no 2541 0.250461877744694 3618 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1720 st037298 9.481 µM -0.67487567037777 0.248343828857731 no 2542 0.24987737957007 3631 597396 SGTC_2030 5175110 200 µM -0.675709636729895 0.24806383122077 no 2543 0.249612508170533 3668 2831986 SGTC_1339 1486-1321 22.7 µM -0.676548778972592 0.247782265895742 no 2544 0.249346143495543 3653 3469382 SGTC_2095 5432005 200 µM -0.676666644932295 0.247742730887822 no 2545 0.249308742006687 3639 783734 SGTC_1353 1498-1206 8.11 µM -0.676764670393069 0.247709853414365 no 2546 0.249277638621097 3686 6756808 SGTC_2058 5236698 133 µM -0.678131779783212 0.247251571576411 no 2547 0.248844071234712 3639 766665 SGTC_2723 salbutamol 83.58 µM -0.678304904324987 0.247193569196414 no 2548 0.248789194875708 3613 9884233 β2-adrenoceptor agonist SGTC_2636 apigenin dimethyl ether 100 µM -0.678740526653497 0.247047653674075 no 2549 0.248651141474751 3649 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2072 5231554 129 µM -0.679176671938592 0.246901609158154 no 2550 0.248512963229596 3707 789545 SGTC_2356 9061756 188.97 µM -0.67990881492106 0.246656552877137 no 2551 0.24828109989784 3622 20104043 SGTC_1144 3486-0183 12.5 µM -0.68261546908117 0.245751738122734 no 2552 0.247424928340098 3664 6744069 SGTC_1768 st044301 37.178 µM -0.682937494637768 0.245644206072612 no 2553 0.247323170027924 3659 3931349 SGTC_3276 9139060 49.47 µM -0.683106862570283 0.245587660203076 no 2554 0.247269659667827 3706 4870619 SGTC_2429 5902844 64.44 µM -0.686864549708708 0.244334903695192 no 2555 0.246084044117969 3679 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2240 6690706 185.951 µM -0.687472576256332 0.24413252099818 no 2556 0.245892488215186 3594 805876 SGTC_445 e6 berbamine 66 µM -0.688233424884151 0.243879398593918 no 2557 0.245652899203342 3705 6610268 A calcium/calmodulin antagonist. SGTC_2971 9092186 9.93 µM -0.688514763480141 0.243785837534389 no 2558 0.245564338260902 3630 25236400 SGTC_2885 9057732 51.95 µM -0.688896553173445 0.24365890177227 no 2559 0.245444184334885 3674 6471414 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.689019952889591 0.243617882008803 no 2560 0.245405355678508 3699 688751 SGTC_2368 9071271 200 µM -0.689257855596228 0.243538810401981 no 2561 0.24533050710555 3650 27209959 SGTC_630 4356-0227 183 µM -0.69092003006943 0.242986741249899 no 2562 0.244807898938989 3665 779312 SGTC_1790 st045711 43.5 µM -0.692414253474728 0.242491033202341 no 2563 0.244338608621728 3686 585119 SGTC_1805 st050013 60.3 µM -0.692565740389084 0.242440808075667 no 2564 0.244291058254321 3631 4037144 SGTC_479 n-linoleoylglycine 10 µM -0.692726896068706 0.242387383479913 no 2565 0.24424047842549 3666 6433346 An anti-infammatory. SGTC_1417 3966-0327 90.4 µM -0.693793024626041 0.242034112751279 no 2566 0.243906008839641 3704 651118 SGTC_347 4534-1311 26.2 µM -0.693952003098921 0.241981457821563 no 2567 0.243856154739836 3681 2862016 SGTC_879 0831-1030 162 µM -0.694132881284473 0.241921557090382 no 2568 0.243799439791957 3695 1549252 SGTC_2131 toluylene red 5.2905 µM -0.694673108129246 0.241742700149236 no 2569 0.243630092288841 3667 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2680 butyl paraben 22.24 µM -0.694709067298803 0.241730797426173 no 2570 0.243618822250513 3697 7184 An antifungal and steroid mimetic. SGTC_2448 5185112 27.17 µM -0.696501979178926 0.241137735235217 no 2571 0.243057259119041 3660 5718189 SGTC_1841 st054148 70 µM -0.697098082401985 0.2409407306347 no 2572 0.242870707092504 3649 675442 SGTC_426 0988-0037 14.6 µM -0.697655619346062 0.240756550961737 no 2573 0.242696294625747 3670 5383008 SGTC_78 0336-0123 156.75 µM -0.698220635129048 0.24056997888133 no 2574 0.242519611776978 3552 6765896 SGTC_47 0149-0135 24.25 µM -0.699947568109018 0.240000222084066 no 2575 0.241980024587709 3652 5239155 SGTC_1671 st016596 74.5 µM -0.700190172693613 0.239920239971947 no 2576 0.241904274004159 3715 2829167 SGTC_1194 1488-0194 225 µM -0.700663677417246 0.239764176364869 no 2577 0.241756464485027 3640 1391452 SGTC_1303 1160-0052 261 µM -0.701205529187914 0.239585654063867 no 2578 0.241587379868404 3680 3562476 SGTC_2714 st079313 56.9 µM -0.701577441516806 0.239463163214196 no 2579 0.241471361954721 3670 2939799 SGTC_881 0833-0569 170 µM -0.702464851269473 0.239171029369981 no 2580 0.241194657099309 3684 5418700 SGTC_1268 0828-0275 2.46 µM -0.704449500681878 0.238518391452495 no 2581 0.240576444170099 3732 745337 SGTC_2713 st079149 53.4 µM -0.706354137407589 0.237892982993873 no 2582 0.23998396714153 3719 3103253 SGTC_2792 7535235 81.82 µM -0.706502512331461 0.237844300233437 no 2583 0.239937845452506 3669 1281891 SGTC_2396 5342950 42.78 µM -0.706894573182634 0.237715688858705 no 2584 0.239815998336823 3690 1886677 SGTC_21 0849-0113 22.993 µM -0.707994356378226 0.237355120424466 no 2585 0.239474381089421 3660 1560156 SGTC_3030 9087619 49.47 µM -0.711789378016297 0.236113216184095 no 2586 0.23829760561389 3681 25236973 SGTC_2769 toremifene 3.73 µM -0.712948131057824 0.235734733920719 no 2587 0.237938927072407 3708 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1193 1488-0126 41.5 µM -0.713039548679887 0.235704888525737 no 2588 0.237910642412067 3714 1384710 SGTC_2552 juarezic acid 87.02 µM -0.713477065351863 0.235562079954625 no 2589 0.237775300051954 3747 1549512 SGTC_2086 5274770 176.623 µM -0.714359021389645 0.235274348348216 no 2590 0.237502602264712 3729 689278 SGTC_2423 st077119 87.2 µM -0.714786448040224 0.235134973415044 no 2591 0.237370505190562 3651 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_362 0310-0100 9.03 µM -0.715762122730693 0.234816997124792 no 2592 0.237069122149419 3745 790235 SGTC_3095 9117207 49.47 µM -0.716084494451955 0.234711987154415 no 2593 0.236969588709592 3673 17015229 SGTC_2720 fluspirilene 36.88 µM -0.718047378672134 0.234073154250001 no 2594 0.23636403708331 3682 3396 An atypical antipsychotic. SGTC_3058 9093861 49.47 µM -0.719009230623557 0.233760465433986 no 2595 0.236067616146472 3711 17217477 SGTC_2583 asiatic acid 100 µM -0.719827407623375 0.233494666297392 no 2596 0.235815633861128 3709 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2705 st078069 42.8 µM -0.720852969016924 0.233161731590181 no 2597 0.235499990840039 3711 1530061 SGTC_2687 chenodiol 100 µM -0.722236615594859 0.232712967266867 no 2598 0.235074507528803 3717 5702181 A cholesterol synthesis inhibitor. SGTC_2316 5844804 197.44 µM -0.722426469936893 0.232651428428198 no 2599 0.235016158822071 3770 776813 SGTC_2292 7671323 168.05 µM -0.724492657076521 0.231982285717949 no 2600 0.234381666784312 3722 937504 SGTC_526 4469-0568 170 µM -0.724553103222151 0.231962726146649 no 2601 0.234363119051179 3713 2901964 SGTC_2417 cerulenin 830 nM -0.725258265667135 0.231734612787676 no 2602 0.23414680192105 3762 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_13 0199-0087 65 µM -0.727739568213277 0.230932929481156 no 2603 0.233386511928992 3749 4589825 SGTC_2540 epiandrosterone 100 µM -0.7277477205869 0.230930298087758 no 2604 0.233384016239132 3790 441302 A steroid. SGTC_3053 9095903 49.47 µM -0.728669952421605 0.230632731546794 no 2605 0.233101788583442 3770 17174018 SGTC_3270 9137563 49.47 µM -0.729311207171076 0.230425951171685 no 2606 0.232905659186655 3711 17015724 SGTC_1916 st067606 49.2 µM -0.729667600924786 0.230311072504112 no 2607 0.232796694893984 3747 19590279 SGTC_2892 9047358 58.44 µM -0.730842643182314 0.229932540613089 no 2608 0.232437636670377 3722 6466771 SGTC_2782 7736369 71.43 µM -0.731005810939778 0.229880004776766 no 2609 0.232387801786819 3781 2950836 YOL077C BRX1 SGTC_14 0354-0009 295 µM -0.731052500316305 0.229864973230661 no 2610 0.232373542957602 3777 1713507 SGTC_2735 sertaconazole 140 nM -0.7331323291014 0.229195935219943 no 2611 0.231738861909805 3790 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3081 9117243 49.47 µM -0.733357954148206 0.229123422012887 no 2612 0.231670068236462 3735 45595589 SGTC_2069 5228469 200 µM -0.733439438450042 0.229097237090346 no 2613 0.231645226254848 3698 2835210 SGTC_2297 7971671 152.32 µM -0.734172120959054 0.228861865504016 no 2614 0.231421921274001 3715 909016 SGTC_817 1391-0715 46 µM -0.734185980862339 0.228857414368973 no 2615 0.231417698247535 3716 1353946 SGTC_334 1502-1024 68.5 µM -0.7345013047218 0.22875616062339 no 2616 0.23132163263634 3760 3296216 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.73465615796654 0.228706444858054 no 2617 0.231274463661189 3719 2333 A French combination drug. SGTC_2239 6685329 187.64 µM -0.73627455691502 0.228187219678423 no 2618 0.23078181345228 3774 805680 SGTC_1897 st060201 15 µM -0.736732477023738 0.228040427176229 no 2619 0.230642526322929 3782 611878 SGTC_1413 3910-0535 34.4 µM -0.737765912547286 0.227709340661221 no 2620 0.230328355377631 3737 2876951 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.738768089309429 0.227388527252217 no 2621 0.230023915981202 3733 616764 SGTC_1105 epirubicin 18.1 µM -0.739154210147869 0.227264991548835 no 2622 0.229906681030484 3738 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1120 ficusin 1.78878 µM -0.739423764405506 0.227178772640756 no 2623 0.229824858138367 3838 6199 A DNA cross-linker. SGTC_1612 st002233 45.4 µM -0.739539080998566 0.227141893413423 no 2624 0.229789858896221 3752 1035021 SGTC_834 0312-0008 75.7 µM -0.742818819690694 0.22609441902592 no 2625 0.228795689930578 3738 6385573 YIL048W NEO1 SGTC_2245 6637752 200 µM -0.74288483993019 0.226073361723105 no 2626 0.228775702404153 3777 681890 SGTC_1102 cgs 12066b 26.1 µM -0.746165140277444 0.225028499373795 no 2627 0.227783831657582 3750 6438352 A 5-HT1B full agonist. SGTC_2676 harmalol 100 µM -0.747739154214655 0.224528107562881 no 2628 0.227308754632191 3735 5459187 A monoamine oxidase inhibitor SGTC_2135 5326629 150.42 µM -0.748276904725103 0.22435729711093 no 2629 0.227146576036133 3733 5020077 SGTC_708 3448-5400 146 µM -0.749116293288665 0.224090822179146 no 2630 0.226893557720103 3725 3462195 SGTC_2193 5925765 200 µM -0.751669158252737 0.223281487392218 no 2631 0.226125021072128 3746 877370 SGTC_3349 9149703 23.001 µM -0.75246878577453 0.223028324050328 no 2632 0.225884597174047 3733 4910494 SGTC_2009 4012297 12.05 µM -0.752870878426887 0.222901082672784 no 2633 0.225763754671444 3767 45595307 SGTC_1677 st019204 53.9 µM -0.753312922593555 0.222761246456958 no 2634 0.225630947590015 3788 3945625 SGTC_1776 st049249 45.9 µM -0.754146820539422 0.222497587405762 no 2635 0.225380532945389 3806 1822314 SGTC_256 clotrimazole 625 nM -0.755451898017355 0.222085309793928 no 2636 0.224988941882665 3727 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2477 5967686 25.23 µM -0.756303742710195 0.221816445055641 no 2637 0.224733552329489 3784 776118 SGTC_2184 6075246 200 µM -0.756574823362108 0.221730923838289 no 2638 0.224652314773195 3818 2267320 SGTC_3286 9117135 37.221 µM -0.756801898794668 0.221659300001565 no 2639 0.224584277540683 3759 3438150 SGTC_805 3852-0218 479 µM -0.757947234187187 0.22129824137768 no 2640 0.224241285885199 3712 6615355 SGTC_722 3534-0461 190 µM -0.75966751028349 0.220756569424164 no 2641 0.223726676993559 3778 658262 SGTC_424 splitomicin 100 mM -0.76115296884855 0.220289447162317 no 2642 0.223282852871092 3850 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1505 k297-0037 20.6 µM -0.762772085508852 0.219780940419539 no 2643 0.222799665754944 3776 4089396 SGTC_2979 9012552 45.46 µM -0.762934253083801 0.219730046524607 no 2644 0.222751303521845 3816 17100905 SGTC_589 1227-0070 34.1 µM -0.763152998251618 0.219661407309061 no 2645 0.222686077981609 3800 2841384 SGTC_891 0929-0073 133 µM -0.763948167549023 0.219411997905385 no 2646 0.222449065749002 3835 5603632 SGTC_167 3672-0051 66.205 µM -0.764253132076244 0.219316387219695 no 2647 0.222358204643322 3721 3237971 SGTC_3309 9129340 25.759 µM -0.764372184752827 0.219279069023557 no 2648 0.222322739845205 3825 17158987 SGTC_2250 alverine citrate 130 µM -0.765143741057329 0.219037305833685 no 2649 0.222092977903857 3699 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1723 st034307 2.5525 µM -0.767221403646102 0.218387043687144 no 2650 0.221474944621569 3836 867466 SGTC_1474 0330-0125 5.35 µM -0.767965210527813 0.218154519257492 no 2651 0.221253926842108 3792 X1474 SGTC_499 genistein 192 µM -0.768384757580882 0.2180234259468 no 2652 0.221129316607214 3785 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1608 st001473 40.5 µM -0.768624191816505 0.217948631749797 no 2653 0.221058219923665 3749 7292267 SGTC_971 1315-0384 26.7 µM -0.769678963824025 0.21761931945466 no 2654 0.22074517575674 3817 6769120 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.769695216946728 0.217614247284904 no 2655 0.220740354004415 3777 61125 An anti-inflammatory. SGTC_307 1501-1223 22.3 µM -0.769864609676565 0.217561388354597 no 2656 0.220690104495553 3778 2830329 SGTC_2265 7929201 200 µM -0.773071313408509 0.216562136637827 no 2657 0.219740088616507 3766 1265108 SGTC_3046 9092212 49.47 µM -0.77649487598584 0.215498245232886 no 2658 0.218728422544697 3814 25236637 SGTC_330 1488-0319 80.1 µM -0.778312811420591 0.214934545988792 no 2659 0.218192312308817 3843 6846614 SGTC_93 0109-0045 59.227 µM -0.780989285424759 0.214106194516412 no 2660 0.217404398260429 3877 88733 SGTC_651 3253-0966 34.4 µM -0.782238715724347 0.213720140819871 no 2661 0.217037147757456 3833 781462 SGTC_2760 etidronate 98.04 µM -0.783438670279235 0.213349756301732 no 2662 0.21668477760306 3809 3305 A chelator and antioxidant. SGTC_1366 1683-0113 21.9 µM -0.784076493367474 0.213153034763291 no 2663 0.216497613752305 3821 708623 SGTC_1721 st082152 9.2685 µM -0.785269612086995 0.212785329530002 no 2664 0.216147754311984 3752 5296051 SGTC_2968 9090663 33.37 µM -0.786831267530428 0.212304605553317 no 2665 0.215690323565121 3807 25236811 SGTC_2730 imipramine 71.33 µM -0.787817665796531 0.21200129018905 no 2666 0.215401683131972 3809 3696 A tricyclic antidepressant. SGTC_2465 5809242 33.21 µM -0.791689135689623 0.210813273431075 no 2667 0.214270979336079 3820 2731748 SGTC_2832 7992762 51.95 µM -0.792141190688611 0.210674808818477 no 2668 0.214139177374839 3784 2985177 SGTC_1868 st057644 42.7 µM -0.792770960213594 0.21048199914927 no 2669 0.213955639313637 3825 688665 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.792927630778372 0.210434049123434 no 2670 0.213909993963128 3828 688662 SGTC_96 0929-0093 37.281 µM -0.793016584678242 0.210406827069032 no 2671 0.213884080119177 3799 6991579 SGTC_2622 2-methoxyxanthone 59.94 µM -0.79308607592474 0.210385562497749 no 2672 0.213863837362078 3839 71034 A hepatoprotective. SGTC_3346 9158254 43.5805 µM -0.793239614133255 0.210338583727519 no 2673 0.213819115732466 3837 17639500 SGTC_2816 7982706 58.44 µM -0.795030535260859 0.209791062687878 no 2674 0.21329787003339 3888 2981853 SGTC_1519 esterone 74 µM -0.795984678511248 0.209499704108306 no 2675 0.213020470425495 3819 698 A steroid. SGTC_29 0299-0004 12.984 µM -0.797114388370608 0.209155042215016 no 2676 0.212692300353936 3716 16871 A napthoquinone isolated from Swertia calycina. SGTC_125 0133-0007 11.75 µM -0.797716438416827 0.208971499898799 no 2677 0.212517531133082 3903 26541 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.800245691020896 0.208201463460671 no 2678 0.211784230965097 3774 140250 A respiratory chain inhibitor. SGTC_364 0083-0097 67.7 µM -0.800644757555364 0.208080119901712 no 2679 0.211668665942021 3920 5207356 SGTC_3239 9133757 49.47 µM -0.801214840536297 0.207906848056974 no 2680 0.211503640588259 3833 17036923 SGTC_2772 vinpocetine 57.06 µM -0.801251210396441 0.207895796640987 no 2681 0.211493114942843 3822 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1695 st026914 34.495 µM -0.801529837123884 0.207811144093717 no 2682 0.211412488951447 3780 3289191 SGTC_2993 9054257 71.4286 µM -0.802913731599213 0.207390990171616 no 2683 0.211012299353442 3801 6470217 YGL055W OLE1 SGTC_3163 9099914 49.47 µM -0.803578013703105 0.207189490928488 no 2684 0.210820362503991 3850 16268368 SGTC_1479 0549-0158 134 µM -0.804785334543933 0.20682356627093 no 2685 0.210471782989814 3871 5440202 SGTC_1928 4'-methoxychalcone 40.3 µM -0.805448834687417 0.206622630229183 no 2686 0.210280360347504 3898 641818 SGTC_2725 haloperidol 53.21 µM -0.80952706558219 0.205390110080835 no 2687 0.209106020543201 3799 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3250 9135583 49.47 µM -0.811856737312253 0.204688002196401 no 2688 0.208436920655473 3882 7699353 SGTC_622 1348-1566 26.3 µM -0.813222996046771 0.204276909193159 no 2689 0.20804510856829 3899 7340407 SGTC_1377 2944-0135 198 µM -0.814925557399741 0.20376531484885 no 2690 0.207557461444933 3911 1894137 SGTC_71 0417-1750 47.813 µM -0.817150804029478 0.203097814112709 no 2691 0.206921126368108 3795 6811472 SGTC_2270 7924575 90.91 µM -0.81717378343696 0.203090927864276 no 2692 0.206914561168923 3888 1262135 SGTC_3158 9100007 49.47 µM -0.821120154276242 0.201910386053336 no 2693 0.205788915547534 3877 19297233 SGTC_1325 1431-0015 227 µM -0.823570534174253 0.201179436024169 no 2694 0.205091812108972 3830 1103340 SGTC_2473 5854593 8.94 µM -0.82384622674892 0.201097296160035 no 2695 0.205013468836287 3786 2872951 SGTC_1865 st057639 52.2 µM -0.823975101796214 0.201058906019686 no 2696 0.204976852650234 3866 688818 SGTC_2475 5812728 15.03 µM -0.824245623754842 0.200978335472376 no 2697 0.204900004162341 3844 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2623 humulene 100 µM -0.82438094995771 0.200938038042239 no 2698 0.204861567819103 3842 6187145 An anti-inflammatory. SGTC_2543 pimpinellin 60.67 µM -0.824738585507323 0.200831564682423 no 2699 0.204760010180041 3739 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2070 5230947 200 µM -0.8250122684181 0.200750108130306 no 2700 0.204682312771314 3922 2835538 SGTC_3187 9109394 49.47 µM -0.82728768448764 0.200073641619239 no 2701 0.204037011232955 3858 17098090 SGTC_1515 3460-0031 42.1 µM -0.828485007371977 0.199718236151829 no 2702 0.203697941102345 3818 2876596 SGTC_3169 9102970 49.47 µM -0.828565300784301 0.199694415979702 no 2703 0.203675214819699 3943 17027839 SGTC_952 1185-0122 232 µM -0.832059334647798 0.198659517942457 no 2704 0.202687726944046 3813 678600 SGTC_552 k242-0005 476 µM -0.832589107092645 0.198502887477621 no 2705 0.202538252232665 3945 4088318 SGTC_268 camptothecin 39.6153 µM -0.832762059857724 0.198451769069483 no 2706 0.202489468072385 3859 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1564 D-Arginine 115 µM -0.833628671252047 0.1981957505791 no 2707 0.202245131943143 3895 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2797 7859098 81.82 µM -0.834570939784959 0.197917607467187 no 2708 0.201979664949959 3885 972681 SGTC_1173 0443-0020 122 µM -0.835066908451997 0.197771299943481 no 2709 0.201840018635735 3876 5331295 SGTC_1124 fisetin 1.16336 µM -0.835294323513307 0.197704235841765 no 2710 0.201776006355266 3904 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_154 3389-1638 511.116 µM -0.836133062606941 0.197457012736363 no 2711 0.201540025081211 3879 5238686 SGTC_2570 licareol 100 µM -0.837043397475584 0.197188898024527 no 2712 0.201284087384547 3911 443158 SGTC_2280 7785178 200 µM -0.841097997937436 0.195997401966499 no 2713 0.200146518305138 3902 2954328 SGTC_247 mechlorethamine 29.705 µM -0.84364075221242 0.19525241447282 no 2714 0.199435092281821 3797 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_581 0958-0271 211 µM -0.845936773363362 0.194581196435068 no 2715 0.1987940083761 3905 4591145 SGTC_408 cantharidin 100 µM -0.847169028180342 0.194221539230691 no 2716 0.198450457058528 3868 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_981 1488-1094 54.9 µM -0.848990872264172 0.193690541451278 no 2717 0.197943185678379 3877 3449522 SGTC_1503 4585-0012 61.3 µM -0.850412280127463 0.193276870845823 no 2718 0.197547955560749 3946 2922052 SGTC_356 1634-0012 32.5 µM -0.851465085769059 0.192970821954893 no 2719 0.197255525054725 3874 735457 SGTC_3289 9119912 71.43 µM -0.851609149817374 0.192928965802048 no 2720 0.197215529763984 3932 17014829 SGTC_869 0564-0080 44.1 µM -0.851814742023891 0.192869242954028 no 2721 0.197158461425315 3928 6843321 SGTC_2161 5662504 8.5105 µM -0.853418703192017 0.192403693236122 no 2722 0.196713576622566 3877 2859334 SGTC_1987 st072290 61.9 µM -0.853430195092858 0.192400360193084 no 2723 0.196710391351685 3936 54697379 SGTC_2486 5283202 22.39 µM -0.854245016551968 0.192164124195988 no 2724 0.19648462262289 3965 1377751 SGTC_2862 9027634 71.43 µM -0.854970566924426 0.191953919421613 no 2725 0.196283721125879 3839 5012562 SGTC_91 0417-1751 58.384 µM -0.856926281224144 0.1913880157352 no 2726 0.195742813591435 4014 6795624 SGTC_1167 k781-0610 148 µM -0.858426364867028 0.19095464653243 no 2727 0.19532853724612 3931 4525169 SGTC_1293 1000-1278 195 µM -0.859314611297421 0.190698319041722 no 2728 0.195083482554504 3959 678847 SGTC_3028 9087778 49.47 µM -0.860341190831304 0.190402335007349 no 2729 0.194800496629984 3906 17217395 SGTC_1340 1486-1359 257 µM -0.860438279826676 0.190374356859879 no 2730 0.194773746100838 3857 4309068 SGTC_2012 4023501 200 µM -0.862516799266227 0.189775995456686 no 2731 0.194201596351798 3950 3477460 SGTC_2171 5739187 198.077 µM -0.865575799269425 0.188897480973196 no 2732 0.193361415885541 3857 2262761 SGTC_1001 4048-4355 44.4 µM -0.866126449436278 0.188739606243557 no 2733 0.193210411016669 3909 21824233 SGTC_2549 cedrol 20.94 µM -0.866693433684274 0.188577133441364 no 2734 0.19305500208804 3838 6708665 A sedative which affects the nervous system. SGTC_1287 0971-0001 34.6 µM -0.869697114886927 0.1877178495108 no 2735 0.192232974677995 3922 4665869 SGTC_304 1310-0298 97 µM -0.871266576468515 0.187269826351297 no 2736 0.191804307839076 3810 1550234 SGTC_3301 9125354 19.7965 µM -0.871428606197322 0.187223610545509 no 2737 0.1917600860345 3906 41905162 SGTC_145 3737-0113 38.366 µM -0.871719078787523 0.187140776586623 no 2738 0.191680824717608 3910 6849351 SGTC_863 0466-0191 129 µM -0.874978341361011 0.186212888566568 no 2739 0.190792845249339 3974 765160 YPR165W RHO1 SGTC_253 dyclonine 31.25 µM -0.875085808440456 0.186182342114879 no 2740 0.190763609113773 4021 3180 An oral anasthetic. SGTC_2796 7949634 45.45 µM -0.875476179335115 0.186071409189564 no 2741 0.190657432873735 3890 2971588 SGTC_2997 9067075 71.4286 µM -0.876350046501551 0.185823228168882 no 2742 0.190419882916093 3963 27209819 SGTC_3004 9076122 71.4286 µM -0.876465319440486 0.185790505626405 no 2743 0.19038856097167 3974 44782551 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.877224039632377 0.185575216830812 no 2744 0.190182480605237 3910 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1376 2910-0861 41.3 µM -0.877307622909054 0.185551509332459 no 2745 0.190159786453519 3891 1112859 SGTC_1335 1486-0900 202 µM -0.877572171340483 0.185476485402058 no 2746 0.190087968433503 3925 X1335 SGTC_1266 0828-0227 32.9 µM -0.87804476521156 0.185342508229815 no 2747 0.189959712979778 3969 3913820 SGTC_2569 tetrandrine 100 µM -0.878397586595039 0.185242524932873 no 2748 0.18986399681628 3961 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1722 st034304 3.6505 µM -0.878569241876155 0.185193892997266 no 2749 0.189817439544861 3943 4036148 YLR033W RSC58 SGTC_867 0518-0118 155 µM -0.88088992401825 0.184537195229506 no 2750 0.189188700816171 3932 6848158 SGTC_90 0870-0863 4.608 µM -0.883505897526893 0.183798675810527 no 2751 0.188481498764423 3940 1738164 SGTC_1229 0139-0193 12.2 µM -0.887806460123592 0.182588585156305 no 2752 0.187322433680898 4012 3090752 SGTC_943 3253-1379 105 µM -0.888545614823185 0.18238110426857 no 2753 0.187123665274382 3936 668464 SGTC_3015 9080845 49.47 µM -0.888668448989796 0.182346638969761 no 2754 0.18709064619872 4022 5296973 SGTC_469 w7 172 µM -0.890138308959263 0.18193453557352 no 2755 0.186695812492601 4000 45115570 A P450 inhibitor. SGTC_1539 benzyladenosine 56 µM -0.891314844603033 0.18160509130774 no 2756 0.186380143541376 3943 92208 A nucleotide analog. SGTC_3068 9116768 49.47 µM -0.895397857185105 0.18046469657966 no 2757 0.185287222861429 3925 41904888 SGTC_431 k089-0097 107 µM -0.895930644315303 0.180316219959301 no 2758 0.185144903123302 3824 5499420 SGTC_627 1391-0720 175 µM -0.897033948749704 0.180008995919834 no 2759 0.184850401006805 3946 997839 SGTC_491 tetrandrine 80.3 µM -0.897159764391303 0.179973982426744 no 2760 0.184816835875975 3981 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1936 st074407 74.3 µM -0.897496765594331 0.179880218741223 no 2761 0.184726949268551 4014 809813 SGTC_870 0573-2213 57.6 µM -0.897895136844453 0.179769419675042 no 2762 0.184620728801197 3951 3916321 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.898858480258846 0.179501662047428 no 2763 0.184364022926925 3969 7104 SGTC_3137 9097352 49.47 µM -0.899111760439803 0.179431305427216 no 2764 0.184296567256104 3984 44120435 SGTC_2521 angolensin 13.4 µM -0.900217119182526 0.179124459870558 no 2765 0.184002358779461 4046 821428 A flavenoid. SGTC_2894 9048625 32.47 µM -0.901850539327135 0.178671630149938 no 2766 0.183568134224112 3948 4092861 SGTC_824 1304-0008 100 µM -0.901920113815306 0.178652358175875 no 2767 0.183549652897565 3997 768245 SGTC_3117 9124945 49.47 µM -0.904081143774838 0.17805440967034 no 2768 0.182976188082631 3891 17592065 SGTC_3227 9130768 49.47 µM -0.907270116348829 0.177174341306265 no 2769 0.182131986520337 4001 17720899 SGTC_3243 9134147 49.47 µM -0.908274696480488 0.176897674990506 no 2770 0.181866553895276 4033 24282180 SGTC_3193 9111931 49.47 µM -0.908415159317091 0.176859012602523 no 2771 0.181829459749616 3997 17087244 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.910602179095131 0.176257724612297 no 2772 0.18125251097325 3982 3256 An antibiotic and ribosome inhibitor. SGTC_2451 5856223 45.7 µM -0.912744258928235 0.175670047822997 no 2773 0.18068853033247 3961 2179896 SGTC_1225 1216-0074 20.6 µM -0.919443037738191 0.17384027011128 no 2774 0.178931943506839 4011 4241466 SGTC_2927 9011802 47.9 µM -0.920649524336224 0.173512009923309 no 2775 0.178616718511515 4026 43912568 SGTC_302 1094-0063 18.9 µM -0.920794214836606 0.173472669122903 no 2776 0.178578937974844 3958 5440289 SGTC_1964 st076914 61 µM -0.923282975363437 0.172796873364277 no 2777 0.177929878776122 4032 24208661 SGTC_1710 st031758 61.5 µM -0.923535820628518 0.172728310012337 no 2778 0.177864021052701 4026 5394341 SGTC_1374 2889-5571 141 µM -0.923949270533402 0.172616233312676 no 2779 0.177756364329232 4043 2853281 SGTC_909 3448-9333 149 µM -0.92412724010591 0.172568004159037 no 2780 0.177710036135454 3925 3344074 SGTC_2908 7930301 100 µM -0.926580822466129 0.171903967609404 no 2781 0.177072107887777 3981 2223178 SGTC_1683 st010134 710 nM -0.927381895999834 0.171687519160432 no 2782 0.176864143471789 3997 3818134 SGTC_271 rotenone 740 µM -0.928459750280028 0.171396559959263 no 2783 0.176584568497956 4043 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2594 a-mangostin 100 µM -0.931335051434247 0.17062193543296 no 2784 0.175840137973653 4053 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1308 1187-1617 41.4 µM -0.931337259905405 0.170621341319415 no 2785 0.175839566953947 4017 2882570 SGTC_1886 st057356 49.9 µM -0.931794441984377 0.170498380650939 no 2786 0.17572138378122 3971 24207747 SGTC_1792 st045773 43.6 µM -0.933471448203952 0.170047830118476 no 2787 0.175288302764119 3944 2919270 SGTC_2852 9023854 51.95 µM -0.933739647743941 0.169975845507511 no 2788 0.175219103995878 4097 19798528 SGTC_1452 4194-0072 190 µM -0.935790410835235 0.169426067675444 no 2789 0.174690554815661 4072 1343545 SGTC_573 3702-0553 84.7 µM -0.936675796248885 0.169189062648574 no 2790 0.174462675015757 3957 1222756 SGTC_1743 st037606 46.3785 µM -0.936777347175261 0.16916189253058 no 2791 0.174436549994028 3979 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_560 2332-1943 155 µM -0.93757439795445 0.168948737575583 no 2792 0.174231586774688 3978 21177716 SGTC_2966 9084041 48.03 µM -0.938696666820383 0.168648902312304 no 2793 0.173943252636325 3926 17741380 SGTC_1006 4099-6547 255 µM -0.940310257652415 0.168218400929552 no 2794 0.173529219760355 4066 3146833 SGTC_2690 usnic acid 100 µM -0.941853850687543 0.167807236977756 no 2795 0.173133735157088 4041 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2834 9001755 58.44 µM -0.942636710332365 0.167598955648996 no 2796 0.1729333779505 3947 2989575 SGTC_2007 4011539 71.82 µM -0.942781866578879 0.167560354855559 no 2797 0.172896244366477 3996 45595301 SGTC_1046 2001-0062 216 µM -0.942954238610481 0.167514524121117 no 2798 0.17285215509394 3936 739778 SGTC_345 1362-0200 395 µM -0.94457879491468 0.167082979544089 no 2799 0.172436978544706 4022 1419823 SGTC_2315 7733312 200 µM -0.945092596085085 0.166946643552256 no 2800 0.172305802459503 3949 726316 SGTC_89 0302-0250 142.109 µM -0.945868105612762 0.166740999752224 no 2801 0.172107931482774 4114 4203518 YLR208W SEC13 SGTC_1925 st057770 10.1 µM -0.947533481784506 0.166299940409728 no 2802 0.171683501706868 4008 5989122 SGTC_2234 tolnaftate 200 µM -0.949473202338648 0.165787174266679 no 2803 0.171189997514733 4041 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_322 k048-0136 19.3 µM -0.949812207160654 0.165697663202418 no 2804 0.171103841035881 4098 6823282 SGTC_2224 6650123 117.647 µM -0.9502577272187 0.165580075310291 no 2805 0.17099065639038 3991 2908370 SGTC_3123 9126162 49.47 µM -0.950259742606186 0.165579543503654 no 2806 0.170990144488794 4099 25239884 SGTC_842 0271-0008 11.1 µM -0.951516511067165 0.165248131185865 no 2807 0.170671120488006 4084 1221709 SGTC_1737 st035557 69.7 µM -0.951679855653498 0.165205088442078 no 2808 0.170629684328759 3916 5716916 SGTC_2783 7738165 71.43 µM -0.952065170774495 0.165103583248581 no 2809 0.170531965689528 4043 17201110 SGTC_2033 5192550 145 µM -0.954458119728503 0.164474102750094 no 2810 0.169925899430052 4022 182073 SGTC_1037 k284-1091 78.7 µM -0.960489935961095 0.162894307175019 no 2811 0.16840434684904 4017 3334711 SGTC_329 k048-0121 21.3 µM -0.962276756937705 0.162428220713465 no 2812 0.16795530063166 4072 6832902 SGTC_3331 9141060 1.957 µM -0.963030460424215 0.162231880124791 no 2813 0.167766118631294 4003 4906567 YPR165W RHO1 SGTC_2610 ononetin 44.17 µM -0.963957993545824 0.161990468901268 no 2814 0.16753349323792 4043 259632 SGTC_529 4076-0302 30.3 µM -0.967862087366268 0.16097690794029 no 2815 0.166556625467695 4005 5816522 SGTC_695 3505-6186 243 µM -0.96815324626188 0.160901484964767 no 2816 0.166483920392207 4068 1819379 SGTC_207 4185-0010 4.486 µM -0.969658915395426 0.160511818513452 no 2817 0.166108267841217 4101 3761753 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.969815366713302 0.160471364374384 no 2818 0.166069265904704 4010 6708514 SGTC_2455 5377712 9.75 µM -0.970617765140128 0.160263990237814 no 2819 0.165869328038584 4051 2243908 SGTC_2906 7926292 26.41 µM -0.97064316845766 0.160257427793751 no 2820 0.165863000701333 4081 2966319 SGTC_640 3381-0960 37.1 µM -0.972731671746006 0.159718505136171 no 2821 0.165343339951814 4106 1745025 SGTC_2031 5180455 200 µM -0.972745240425366 0.159715007721475 no 2822 0.165339967245228 3996 29949 SGTC_2189 6047310 154.431 µM -0.973815499669585 0.159439299353379 no 2823 0.165074077878596 4036 711535 SGTC_736 0958-0254 92.6 µM -0.975393991817827 0.159033234636296 no 2824 0.16468243140094 4159 6812352 SGTC_212 3807-4682 38.772 µM -0.976194028340902 0.158827685420888 no 2825 0.164484160978072 4122 3125501 YBL034C STU1 SGTC_2767 sibutramine 71.45 µM -0.978577679502843 0.158216299121814 no 2826 0.163894346174559 4080 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_336 4111-0029 111 µM -0.980825812946804 0.157641089069755 no 2827 0.163339323330703 4072 3131175 SGTC_2359 9039622 200 µM -0.982547913462182 0.157201400882442 no 2828 0.162914995234327 4024 6463596 SGTC_800 3448-7362 155 µM -0.98835759062556 0.155724023757928 no 2829 0.16148877483675 4150 15991913 SGTC_170 4197-0004 226 µM -0.988611320521041 0.155659710634813 no 2830 0.161426672662223 4111 218692 SGTC_3051 9093778 49.47 µM -0.989426307186156 0.155453253817297 no 2831 0.161227304313888 4117 17217378 SGTC_2157 5649910 96.377 µM -0.990013689881678 0.155304566948028 no 2832 0.161083713858516 4081 2858091 SGTC_1074 carmofur 3.8 µM -0.992071500387172 0.15478440459512 no 2833 0.160581323921012 4114 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1668 st014914 51.6 µM -0.99223374353585 0.154743442645313 no 2834 0.160541757762025 4098 2839556 SGTC_905 2-aminofluorene 215 µM -0.99225955985775 0.154736925391918 no 2835 0.160535462535312 4081 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3305 9127027 53.8275 µM -0.993079339630573 0.15453006874895 no 2836 0.160335645748129 4013 41905295 SGTC_489 paxilline 115 µM -0.994129365366965 0.154265380804998 no 2837 0.160079945305011 4083 105008 A toxic potassium channel blocker. SGTC_2192 5915882 198.485 µM -0.99503239518558 0.154037987177318 no 2838 0.159860254422827 4033 2876149 SGTC_202 3594-0513 34.79 µM -0.996714339537346 0.153615045097784 no 2839 0.159451593677081 4094 708429 SGTC_2734 clemastine 41.6 µM -0.997323611369676 0.15346202737513 no 2840 0.159303728251333 4118 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1294 1000-1494 117 µM -0.999942738569741 0.152805387602854 no 2841 0.158669109917919 4087 712797 YDL207W GLE1 SGTC_2212 7123476 200 µM -1.00144716998406 0.15242905630204 no 2842 0.158305334541584 4054 1085715 SGTC_3008 9078912 71.4286 µM -1.00198087029279 0.152295699893555 no 2843 0.158176416039286 4074 16648731 SGTC_1966 st070145 16.1 µM -1.00211753569693 0.152261563586112 no 2844 0.158143414777483 4050 3748532 SGTC_2976 9009005 19.48 µM -1.00213913458624 0.152256169076816 no 2845 0.158138199601887 4128 2993148 SGTC_2111 5486399 200 µM -1.00412139990702 0.151761621357282 no 2846 0.157660050853875 4062 689674 SGTC_850 0388-0143 75.9 µM -1.00497644442807 0.151548629498666 no 2847 0.157454096257706 4054 67273 SGTC_2607 solasodine 47.35 µM -1.00745530339122 0.150932268626004 no 2848 0.156858013259973 4079 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_575 k072-0246 11.9 µM -1.00806659355896 0.150780529970463 no 2849 0.156711246867607 4171 6796779 SGTC_2238 6671620 73.2395 µM -1.00905533371453 0.150535313143794 no 2850 0.156474048823485 4027 729941 SGTC_2558 carylophyllene oxide 100 µM -1.00909911406818 0.150524461350674 no 2851 0.156463551417108 4222 6708694 An oxygenated terpenoid and antifungal agent. SGTC_574 1315-0397 40 µM -1.00994690535352 0.150314422906757 no 2852 0.156260364243132 4071 6794277 SGTC_3241 9133421 49.47 µM -1.01063755791013 0.150143459667027 no 2853 0.156094966497046 4127 17018221 SGTC_1706 st031321 9.9705 µM -1.01329063865092 0.149487925203479 no 2854 0.15546067882483 4114 6103185 SGTC_617 3770-0098 35 µM -1.01593733427852 0.148835874535271 no 2855 0.154829614427985 4030 5962639 SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.01663715446587 0.148663782195676 no 2856 0.154663036204009 4199 5282309 SGTC_2173 5763948 167 µM -1.02192920676175 0.147366724180481 no 2857 0.153407203904844 4090 2867177 SGTC_730 1436-0052 41.2 µM -1.02266745073241 0.147186388517051 no 2858 0.15323255304668 4153 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1072 oxiconazole 14.9 nM -1.02357056137421 0.146965981061283 no 2859 0.153019077926893 4119 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2635 hydroquinidine 100 µM -1.02788080123968 0.145917101610078 no 2860 0.152002950789762 4043 442912 An experimental heart treatment. SGTC_9 0092-0002 10.449 µM -1.02879683025079 0.14569483938982 no 2861 0.151787578277403 4098 759368 SGTC_1856 st057054 55.7 µM -1.02882900538396 0.145687036662712 no 2862 0.151780017096748 4133 1266018 SGTC_2259 7964009 200 µM -1.03010213629634 0.145378517711455 no 2863 0.15148103125477 4168 313134 SGTC_2424 5537928 59.2 µM -1.03086753596139 0.145193249410382 no 2864 0.151301471130689 4134 5382802 SGTC_2151 5563267 85.4165 µM -1.03223245698334 0.144863258806135 no 2865 0.150981616817539 4170 5310824 SGTC_2206 7254556 146.969 µM -1.03287196177666 0.144708822571893 no 2866 0.150831910790439 4122 4398905 SGTC_2702 st077768 96.8 µM -1.03314036573131 0.144644037818074 no 2867 0.150769107734172 4117 6484119 SGTC_1326 1431-2094 10.8 µM -1.03593903949277 0.143969684962639 no 2868 0.15011529156901 4102 616278 SGTC_2652 actinonin 100 µM -1.03646511137502 0.143843162750682 no 2869 0.14999260388661 4129 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1867 st057372 64 µM -1.03714807436241 0.143679019588866 no 2870 0.149833426665511 4085 688837 SGTC_966 1300-0360 30.2 µM -1.03774118974755 0.143536572969929 no 2871 0.14969528154309 4107 70588 SGTC_754 3474-0146 171 µM -1.04322776390043 0.142223400136939 no 2872 0.148421408828601 4104 24762078 SGTC_2001 4023502 57.655 µM -1.04430632598415 0.141966213105804 no 2873 0.1481718435102 4176 108941 YCR052W RSC6 SGTC_1171 0368-0077 21.4 µM -1.04546800032526 0.141689560057304 no 2874 0.147903361336114 4079 3239779 SGTC_231 b-estradiol 524 µM -1.04841746215065 0.140988786492662 no 2875 0.147223155834344 4127 450 A steroid. SGTC_629 3448-6466 76.7 µM -1.0489046205556 0.14087326731572 no 2876 0.147111009360956 4135 573744 SGTC_2737 bleomycin 30.5 nM -1.04893571488016 0.140865896143614 no 2877 0.147103853226031 4179 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2062 5245942 200 µM -1.04959533096277 0.140709590232834 no 2878 0.146952102324231 4187 1376160 SGTC_1696 st025591 34.7925 µM -1.05051963315371 0.140490761069247 no 2879 0.146739634581638 4159 2787147 SGTC_2996 9066192 71.4286 µM -1.05086000746171 0.140410235460316 no 2880 0.146661445279571 4190 6472854 SGTC_205 1486-1330 71.903 µM -1.05363616958405 0.139754622470804 no 2881 0.146024761441585 4172 4118834 SGTC_3248 9135562 49.47 µM -1.05533623680618 0.139354166974218 no 2882 0.14563578686891 4121 17650701 SGTC_64 000l-0018 272.079 µM -1.05803869356624 0.138719204066692 no 2883 0.145018901109312 4075 6811119 SGTC_3182 9108849 49.47 µM -1.05898085769587 0.13849829939662 no 2884 0.144804248812823 4189 17133045 SGTC_2561 acetosyringone 100 µM -1.05964972053826 0.1383416199296 no 2885 0.14465199239659 4132 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1625 st003711 30.1 µM -1.06011461100509 0.138232791682463 no 2886 0.144546230724324 4231 24207034 YER133W GLC7 SGTC_1093 fluphenazine 7.97 µM -1.06065783879542 0.138105699073823 no 2887 0.144422713485654 4157 6602611 An atypical antipsychotic. SGTC_911 3456-4043 236 µM -1.06284807254619 0.137594084335742 no 2888 0.143925427454759 4167 914281 SGTC_2497 7-hydroxyflavone 100 µM -1.06441496177587 0.13722887084145 no 2889 0.143570379441653 4182 5281894 SGTC_777 1315-0167 517 µM -1.06514057424538 0.137059968228669 no 2890 0.143406160309785 4174 4221767 SGTC_795 0685-0265 78 µM -1.06515121820125 0.137057491666203 no 2891 0.143403752335657 4174 302754 SGTC_1775 st081588 35.1725 µM -1.06655709526371 0.136730650557834 no 2892 0.14308594174863 4160 1426443 YGL099W LSG1 SGTC_3320 9137005 35.139 µM -1.07028816634342 0.135865828885111 no 2893 0.142244809655792 4183 4908713 SGTC_1447 4239-0816 81.9 µM -1.07159557914603 0.135563672966945 no 2894 0.141950859935467 4172 1341554 SGTC_765 1319-0117 244 µM -1.07204484411363 0.135459949794327 no 2895 0.141849945293852 4128 3487746 YGL099W LSG1 SGTC_209 4077-0173 175.592 µM -1.07236785755066 0.135385408313253 no 2896 0.141777419508319 4144 15993494 SGTC_2452 5863136 48.41 µM -1.07267919716916 0.135313587399669 no 2897 0.141707538602598 4122 2184096 SGTC_1888 azatryptophan 97.5 µM -1.07335936663192 0.135156774389861 no 2898 0.141554954145906 4214 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1729 st035615 45.989 µM -1.07504652711187 0.134768337727533 no 2899 0.141176949039346 4198 17385451 SGTC_3189 9110682 49.47 µM -1.07781805176699 0.134131910858345 no 2900 0.140557480977206 4240 17122418 SGTC_2360 9040895 200 µM -1.08267893080306 0.133020696901307 no 2901 0.13947547952469 4202 4914414 SGTC_92 0063-0024 660.874 µM -1.08291829727125 0.132966141082434 no 2902 0.139422344794595 4264 3594437 SGTC_1899 st063254 59.6 µM -1.08529019571722 0.132426376340277 no 2903 0.138896573432835 4123 3093813 SGTC_2907 7721985 69.9 µM -1.08681494341582 0.13208019314885 no 2904 0.1385593011301 4196 3267881 SGTC_1119 parthenolide 318.541 nM -1.08747376562186 0.131930805464555 no 2905 0.138413743258449 4279 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1469 k284-2957 126 µM -1.0922277405693 0.130856298138739 no 2906 0.137366506108232 4180 23884841 SGTC_3016 9080866 49.47 µM -1.09399745525612 0.130457851133167 no 2907 0.136978047145164 4165 17066299 SGTC_3299 9121982 43.1275 µM -1.09417232042009 0.13041852626264 no 2908 0.136939704382904 4236 17594604 YPL160W CDC60 SGTC_2854 9024559 71.43 µM -1.09457947579039 0.130326994159237 no 2909 0.136850455667905 4232 3163529 SGTC_1152 3909-8331 15.9 µM -1.09772227136056 0.129621961519351 no 2910 0.136162890803919 4147 16001939 SGTC_2440 5628896 157.78 µM -1.09818579882493 0.129518201012776 no 2911 0.136061683029664 4167 5522048 SGTC_1839 st053978 48 µM -1.0982559178126 0.129502509907173 no 2912 0.136046377555348 4208 3788398 SGTC_214 4373-3496 70 µM -1.09853791469205 0.129439418433525 no 2913 0.13598483557312 4266 3779166 SGTC_991 3996-0057 64.7 µM -1.0988933508786 0.129359926646834 no 2914 0.135907293615635 4253 715343 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.09949113630801 0.129226310794689 no 2915 0.135776949036623 4140 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1292 0kpi-0043 232 µM -1.10006966346624 0.129097090636547 no 2916 0.13565088519008 4216 3333905 SGTC_1288 0973-0013 65.5 µM -1.10064978084681 0.128967605271951 no 2917 0.135524555361484 4232 4315430 SGTC_1064 honokiol 6.76 µM -1.10140604044594 0.128798939284681 no 2918 0.135359988828516 4203 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2044 5102272 200 µM -1.10379436903229 0.128267283515826 no 2919 0.134841174030105 4193 592666 SGTC_204 PMA1.184 62.41 µM -1.10426241955555 0.128163271600401 no 2920 0.134739659862927 4192 2252213 YGL008C PMA1 SGTC_3232 9132874 49.47 µM -1.10707974336277 0.127538433037448 no 2921 0.134129726335983 4157 3784940 SGTC_729 4092-0585 94.1 µM -1.10822336440035 0.127285401093832 no 2922 0.133882681373858 4203 2169061 SGTC_1960 st011366 51.8 µM -1.10865174163922 0.127190710424469 no 2923 0.133790223902408 4204 3972846 SGTC_1026 k007-1105 30.6 µM -1.10877512548692 0.127163446128777 no 2924 0.133763601875906 4189 7066794 SGTC_510 ag-490 170 µM -1.11193546538375 0.126466487245136 no 2925 0.133082949315441 4331 5328779 SGTC_1719 st032227 49.2 µM -1.11202160182882 0.126447528653743 no 2926 0.133064431265168 4210 3125804 SGTC_1613 st002381 52.1 µM -1.11349500134313 0.126123540693771 no 2927 0.132747946984542 4182 551167 SGTC_1934 st074720 32.6 µM -1.11435010142994 0.125935777094049 no 2928 0.132564510537187 4147 17250992 SGTC_3002 9075603 71.4286 µM -1.1153778082319 0.125710370396437 no 2929 0.132344277586737 4146 20105405 SGTC_706 4262-0057 46.9 µM -1.11644649155371 0.125476274999027 no 2930 0.132115531145939 4214 883298 SGTC_171 k064-0041 9.68 µM -1.11759705225516 0.125224584627097 no 2931 0.131869564158379 4226 53325 SGTC_792 4534-1957 155 µM -1.11823500378186 0.12508518185404 no 2932 0.13173331903357 4164 1717904 SGTC_2195 6536160 144.242 µM -1.11862060125527 0.125000975114384 no 2933 0.131651015412594 4182 3834386 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.11994664410282 0.124711696268068 no 2934 0.131368249877901 4254 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2489 cantharidin 73.42 µM -1.12364001397445 0.12390844789536 no 2935 0.130582886869672 4169 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_672 1441-0018 53.7 µM -1.12678460210169 0.123227410342017 no 2936 0.129916781142944 4211 251141 SGTC_815 1582-0027 36.9 µM -1.12907463590044 0.122733101021888 no 2937 0.129433175025102 4256 3128206 SGTC_1342 1486-1464 234 µM -1.12974852731967 0.12258790514321 no 2938 0.129291101428317 4242 3253938 SGTC_1145 3546-0597 10.2 µM -1.1300145358057 0.122530624443832 no 2939 0.129235049780925 4191 875334 SGTC_3223 9129970 49.47 µM -1.13107809537717 0.122301791451262 no 2940 0.129011111464311 4236 17248386 SGTC_2480 5767542 37.17 µM -1.13122371891542 0.122270482794924 no 2941 0.128980470584278 4168 2867358 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.1313011250532 0.122253842980594 no 2942 0.128964185490292 4251 4620898 SGTC_363 0455-0021 3.06 µM -1.13154319592548 0.122201815837224 no 2943 0.128913266601093 4188 4597466 SGTC_1290 0986-0249 10.2 µM -1.13156582048128 0.122196954043274 no 2944 0.12890850830557 4080 53329 SGTC_2727 riluzole 51.77 µM -1.1348180707817 0.121499489857776 no 2945 0.128225776552031 4259 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_326 k292-0812 17.5 µM -1.13556131282436 0.121340490847719 no 2946 0.128070103901124 4213 3579357 SGTC_3327 9140648 26.9345 µM -1.13613190259629 0.121218526011769 no 2947 0.127950682523606 4249 8029710 SGTC_1133 3473-0247 50 µM -1.13714606133026 0.121001960186798 no 2948 0.127738615556806 4214 711311 SGTC_2134 5324836 1.464 µM -1.13837176201286 0.120740584703503 no 2949 0.127482640050876 4173 699272 SGTC_2318 6029776 164 µM -1.146718825312 0.118971175856149 no 2950 0.125748923749399 4292 818325 SGTC_1574 spiramycin 23.7 µM -1.1479164199852 0.118718819760414 no 2951 0.125501534499358 4199 6419898 An antibiotic and protein synthesis inhibitor. SGTC_957 1187-1561 14.1 µM -1.14833909048574 0.118629845354547 no 2952 0.125414303853287 4192 1538454 SGTC_2404 5161160 200 µM -1.15065631456429 0.118142894485286 no 2953 0.124936827667952 4184 2831543 SGTC_1745 st081495 74 µM -1.15319294007344 0.117611460287612 no 2954 0.124415600318465 4112 13842402 YBL026W LSM2 SGTC_3057 9095946 49.47 µM -1.15409354737548 0.117423186764902 no 2955 0.124230909268867 4285 24540043 SGTC_543 3844-1095 191 µM -1.15436058042961 0.117367404083578 no 2956 0.124176184640129 4249 4230703 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.15441776954254 0.117355459830417 no 2957 0.124164466737285 4274 6708561 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.15641372214188 0.116939133612679 no 2958 0.123755985714121 4236 229346 A bile salt which induces apoptosis. SGTC_883 0850-0245 24.6 µM -1.15948540695479 0.116300472388629 no 2959 0.123129190739575 4316 6823229 YPR165W RHO1 SGTC_1400 3771-8998 51.5 µM -1.1607939398731 0.116029156778849 no 2960 0.122862854028474 4176 670767 SGTC_2040 5100729 123 µM -1.16104251677401 0.115977666835036 no 2961 0.122812304775907 4275 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1857 st056007 79.3 µM -1.17224782165455 0.11367343790245 no 2962 0.120548786874736 4233 619834 SGTC_3325 9138760 55.175 µM -1.17229345693854 0.113664120794114 no 2963 0.120539628823308 4198 43844959 SGTC_1092 toremifene 6.32 µM -1.17252688360854 0.113616471851333 no 2964 0.120492792612234 4244 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_433 pimozide 108 µM -1.17261848294975 0.11359777774287 no 2965 0.120474417039794 4168 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_94 0334-0113 514.748 µM -1.17645071999901 0.112817637435342 no 2966 0.11970740696881 4281 6795178 SGTC_1522 st012842 45.6 µM -1.17765427315011 0.112573417539739 no 2967 0.119467231777646 4110 3491067 YOR116C RPO31 SGTC_1765 st044815 90.4 µM -1.17774405941252 0.112555213639794 no 2968 0.119449328106432 4288 645695 SGTC_772 k072-0172 35.3 µM -1.17812477170896 0.11247804870396 no 2969 0.11937343387435 4310 5861980 SGTC_1670 st016595 4.04 µM -1.18201230840142 0.111692263221169 no 2970 0.118600408534368 4293 597879 SGTC_3184 9108758 49.47 µM -1.18571110536357 0.110948280672107 no 2971 0.117868203683612 4292 902885 SGTC_2084 5306078 60.6385 µM -1.18600750406054 0.110888816507687 no 2972 0.1178096680424 4198 679340 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.18719762664172 0.11065028136841 no 2973 0.117574838416034 4256 2724 A muscle relaxant with antifungal properties. SGTC_232 clozapine 119 µM -1.18797656463022 0.110494358811404 no 2974 0.117421321408211 4253 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1752 st044819 83.042 µM -1.19022212447076 0.110045739514059 no 2975 0.116979549780384 4248 441209 YML126C ERG13 SGTC_2390 9097792 176.6 µM -1.19318952264361 0.109454917445491 no 2976 0.116397578530446 4299 4497149 SGTC_963 1269-2853 151 µM -1.19804392610658 0.108493302275686 no 2977 0.115449958400418 4255 3668223 SGTC_1662 st014054 52 µM -1.20041688703567 0.108025457299002 no 2978 0.114988736820961 4332 2838777 SGTC_1963 st076565 50.3 µM -1.20134327157775 0.107843209242441 no 2979 0.114809035809778 4308 4914280 SGTC_904 1141-0088 396 µM -1.20346399487247 0.107426832379532 no 2980 0.114398408182293 4295 1378119 SGTC_2596 sinensetin 100 µM -1.21122494234998 0.105912951156327 no 2981 0.112904602957129 4311 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2367 9070478 135.38 µM -1.21321442964233 0.105527368672314 no 2982 0.11252392433673 4224 572802 SGTC_2154 5570129 200 µM -1.2156148771753 0.10506349065058 no 2983 0.11206583208968 4344 673366 SGTC_2903 5923464 63.88 µM -1.21755186824669 0.104690251308847 no 2984 0.111697157256607 4308 2876576 SGTC_246 cycloheximide 667 µM -1.21901338404537 0.104409267757781 no 2985 0.111419556313579 4202 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_277 nystatin 15.5 µM -1.21956742888547 0.104302892903564 no 2986 0.111314449979034 4316 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_323 4013-0906 34.3 µM -1.22086168170933 0.104054706564758 no 2987 0.111069197413798 4330 2910086 SGTC_66 0109-0187 42.4 µM -1.22329343867392 0.103589550673032 no 2988 0.110609442241992 4171 759417 SGTC_2850 9015429 58.44 µM -1.22384204295794 0.103484820447491 no 2989 0.110505910334275 4316 6457570 SGTC_143 4032-1194 15.74 µM -1.22529421315738 0.103207967732678 no 2990 0.110232193980135 4340 1806963 SGTC_2168 5727979 200 µM -1.22786379624778 0.102719401513235 no 2991 0.10974905105492 4224 695210 SGTC_481 bay k-8644 50 µM -1.23040361567232 0.102238148299114 no 2992 0.109273000033998 4272 2303 A calcium channel antagonist. SGTC_1097 itavastatin 7.23 µM -1.23042694218072 0.10223373593023 no 2993 0.109268634716162 4326 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1764 st044502 93.5 µM -1.23127448836713 0.102073510697427 no 2994 0.10911011007031 4340 8407 SGTC_496 calpeptin 138 µM -1.23273479780569 0.101797873748432 no 2995 0.108837362305687 4308 73364 A calpain inhibitor. SGTC_1789 tunicamycin 25 nM -1.23576173919045 0.1012282575557 no 2996 0.108273570402658 4207 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3114 9122766 49.47 µM -1.23648878160781 0.10109178776509 no 2997 0.108138466589361 4319 17176985 SGTC_166 k072-0058 166.424 µM -1.23759347773041 0.100884687072292 no 2998 0.107933417032754 4204 5846229 SGTC_1444 4112-3581 28 µM -1.23767106574858 0.100870153048774 no 2999 0.107919025965893 4380 2877249 SGTC_1286 0929-0070 131 µM -1.24193762970818 0.100073275923566 no 3000 0.107129787468808 4398 1420408 SGTC_2332 7982454 138.89 µM -1.24205152737787 0.100052066134499 no 3001 0.107108775617816 4241 2981748 SGTC_1864 st057645 30.4 µM -1.24330964522713 0.0998180003653764 no 3002 0.106876875652283 4358 688666 SGTC_1600 coumarin 106 71.1 µM -1.24864174939364 0.0988304318041628 no 3003 0.105898067540195 4388 100336 A hepatotoxic, DNA x-linker. SGTC_1389 3405-0187 19 µM -1.25088261134653 0.0984175383170097 no 3004 0.105488654427468 4295 799890 SGTC_3121 9125696 49.47 µM -1.25165487822237 0.0982755361623609 no 3005 0.105347824224646 4437 1235365 SGTC_2433 5607874 27.82 µM -1.25191994679269 0.09822683074635 no 3006 0.105299517819971 4283 2252428 SGTC_2537 larixol 68.93 µM -1.25861165273112 0.0970031047607115 no 3007 0.10408531801051 4310 6708759 SGTC_3285 9112818 20.8695 µM -1.25879986591926 0.0969688483745857 no 3008 0.104051314401266 4305 17017947 YPR165W RHO1 SGTC_1478 0453-0656 35.7 µM -1.25971577097314 0.0968022726958777 no 3009 0.103885957021943 4333 5258496 SGTC_1231 0242-0792 125 µM -1.25972389255424 0.096800796564159 no 3010 0.103884491605752 4330 3707635 SGTC_3112 9123419 49.47 µM -1.26403667367969 0.096019263405168 no 3011 0.103108432061808 4387 17015854 SGTC_2146 5545642 200 µM -1.26629959691528 0.0956110523379202 no 3012 0.102702920610468 4296 825326 SGTC_1697 st025554 27.742 µM -1.26696296493988 0.0954916290884659 no 3013 0.102584266336599 4351 1269519 SGTC_269 exalamide 29 µM -1.26949702605169 0.0950364438154144 no 3014 0.102131925279608 4279 3316 A derivative of salicylamide. SGTC_1879 gemcitabine 100 µM -1.26968381745903 0.095002954428228 no 3015 0.102098639706148 4312 60750 A nucleoside analog which inhibits DNA replication. SGTC_1898 st060199 18.6 µM -1.27047106628036 0.09486190598269 no 3016 0.101958441456304 4321 688866 SGTC_837 0091-0265 12.5 µM -1.27218887735259 0.0945546679381838 no 3017 0.101653009287419 4335 759367 SGTC_3272 9137413 49.47 µM -1.27303961713232 0.0944027812885452 no 3018 0.101501992006355 4257 17614870 SGTC_272 doxorubicin 8.13 µM -1.27410749189389 0.0942123832376881 no 3019 0.101312661832001 4364 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_126 0417-1624 672.48 µM -1.27550231269146 0.0939641187635157 no 3020 0.101065753047849 4391 41912 YDL195W SEC31 SGTC_893 0958-0369 48.9 µM -1.27587585951737 0.093897713112491 no 3021 0.100999702949792 4257 6819948 SGTC_104 0074-0074 590.992 µM -1.27757494838156 0.093596102069829 no 3022 0.100699669163839 4185 3943124 SGTC_2381 9035592 200 µM -1.2785154704345 0.0934294547168388 no 3023 0.100533866748885 4353 4749657 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.28028396849165 0.0931166952855528 no 3024 0.100222641899674 4334 689007 SGTC_370 0180-0345 38.7 µM -1.28068456849207 0.0930459566635514 no 3025 0.100152241079421 4189 3989527 SGTC_590 k048-0076 22.4 µM -1.28260913902918 0.0927066665008368 no 3026 0.0998145233720179 4376 6832814 SGTC_1892 st058411 7.36 µM -1.28290343387889 0.0926548648573935 no 3027 0.0997629548329347 4342 3934738 SGTC_1321 1326-2144 215 µM -1.28558093652879 0.0921845552066302 no 3028 0.0992946766826309 4345 3513030 SGTC_3118 9124250 49.47 µM -1.28579517779148 0.0921469997209008 no 3029 0.0992572768079504 4310 1504786 SGTC_40 0327-0103 19.753 µM -1.2862963065412 0.0920591984426447 no 3030 0.0991698355087702 4199 409036 SGTC_3317 9138495 8.753 µM -1.28784302974649 0.0917885923241788 no 3031 0.0989003050838483 4268 17020139 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.28921780319753 0.0915485645941191 no 3032 0.0986611886903772 4416 279621 SGTC_3229 9132204 49.47 µM -1.29059465636289 0.0913086402824031 no 3033 0.0984221349605306 4435 17682924 SGTC_2000 st075254 36.4 µM -1.29162267504807 0.0911298065123066 no 3034 0.0982439237674557 4252 17234175 SGTC_1614 st002383 48.6 µM -1.29381960419269 0.0907485004255431 no 3035 0.0978638697285538 4390 1947235 SGTC_2214 7179297 48.276 µM -1.29658519904401 0.0902701798892878 no 3036 0.0973869738996183 4430 769744 SGTC_1259 0671-0132 43 µM -1.29914074486919 0.0898298550840619 no 3037 0.0969478161811718 4289 X1259 SGTC_1488 4013-0813 75.9 µM -1.30008314901419 0.0896678808381286 no 3038 0.0967862362262282 4326 2910057 SGTC_615 k087-0205 167 µM -1.30350189601921 0.0890821116096865 no 3039 0.0962017347483397 4393 9642773 SGTC_1440 4100-1550 40 µM -1.30996346975748 0.0879827697161275 no 3040 0.095104096915284 4371 742806 SGTC_2987 9018338 71.43 µM -1.31057596731909 0.0878790894963819 no 3041 0.0950005315386374 4381 5055682 SGTC_342 k048-0088 23.3 µM -1.31184285487933 0.0876649269426972 no 3042 0.0947865809944198 4369 6820570 SGTC_1051 3253-3903 78 µM -1.3122388675424 0.087598062448195 no 3043 0.0947197757191227 4369 5509239 SGTC_3185 9108267 49.47 µM -1.31548023375871 0.0870522059782939 no 3044 0.0941742780584215 4376 4910486 SGTC_328 k915-0120 63.5 µM -1.31628506549355 0.086917064282935 no 3045 0.0940391907709625 4384 6624543 SGTC_1075 aripiprazole 15.2 µM -1.31873602202606 0.0865064822956373 no 3046 0.0936286898044798 4434 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1402 3909-7673 35.9 µM -1.31893921138807 0.0864725093964339 no 3047 0.0935947179116773 4387 5328014 SGTC_2248 tofa 1.1 µM -1.31986187389494 0.0863183673497904 no 3048 0.0934405694589679 4390 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2758 dehydroepiandrosterone 69.35 µM -1.32064083303303 0.0861883927527479 no 3049 0.0933105754638996 4375 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2951 9072950 58.06 µM -1.32426559950732 0.0855855010523428 no 3050 0.0927074255577014 4311 16488155 SGTC_2950 9072895 21.46 µM -1.3260066674264 0.0852970419018051 no 3051 0.0924187444553723 4343 17332245 SGTC_835 0312-0010 67.2 µM -1.32689570960107 0.0851500271079478 no 3052 0.0922715919075458 4394 1626196 SGTC_785 1270-0111 65.3 µM -1.3311501786932 0.0844491224241231 no 3053 0.0915698004350237 4311 6741994 SGTC_2937 9044753 11.33 µM -1.33356574413357 0.0840531001895259 no 3054 0.0911731079188772 4321 6465530 YGL099W LSG1 SGTC_1137 ixabepilone 100 µM -1.33453668465256 0.0838943118498647 no 3055 0.0910140162794095 4335 154225 A novel microtubule stabilizer. SGTC_948 3448-0295 75.3 µM -1.34124054416468 0.0828040998446241 no 3056 0.0899211833080061 4376 678569 SGTC_2068 5226020 147 µM -1.34228095484641 0.0826358634646559 no 3057 0.0897524581092016 4404 1810509 SGTC_2990 9074105 71.4286 µM -1.34407850236093 0.0823458030276314 no 3058 0.0894615014826802 4310 6502001 SGTC_2213 7173844 200 µM -1.34777081083343 0.0817524011746075 no 3059 0.0888660544249867 4392 892728 SGTC_2881 9058953 51.95 µM -1.34831600255936 0.0816650555990207 no 3060 0.0887783836603579 4340 17122249 SGTC_1401 3807-4679 7.6 µM -1.35270922090579 0.0809637807845645 no 3061 0.0880742717422372 4326 3291456 SGTC_2560 caryophyllene 100 µM -1.35457249320229 0.0806677293515315 no 3062 0.0877769010976254 4433 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1774 st048371 48.465 µM -1.36250317630701 0.0794167797718527 no 3063 0.0865195712140201 4392 4242727 SGTC_308 4092-1169 104 µM -1.36670226104437 0.0787604084578836 no 3064 0.0858593244360628 4372 2268590 YDL196W YDL196W SGTC_1364 1653-0028 37.6 µM -1.36764662579952 0.0786133597964799 no 3065 0.0857113571803061 4405 5718652 SGTC_2478 5763493 32.33 µM -1.37006338659816 0.0782379895386307 no 3066 0.0853335578905861 4347 1365576 YLR208W SEC13 SGTC_3005 9076496 71.4286 µM -1.37496313960472 0.0774811358795942 no 3067 0.0845714363095114 4389 21368410 SGTC_2018 5133068 143 µM -1.37617793493907 0.0772943521846082 no 3068 0.0843832758206842 4383 785362 SGTC_2236 dapsone 200 µM -1.37989612744497 0.0767247784102169 no 3069 0.0838093145630365 4436 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2202 7226349 200 µM -1.38000290943122 0.0767084682134285 no 3070 0.0837928745139612 4405 844334 SGTC_284 0988-0104 32.6 µM -1.38371306798751 0.0761434034717574 no 3071 0.0832231652712301 4390 4666532 SGTC_2712 st079126 47.7 µM -1.38650455518242 0.0757203471966239 no 3072 0.0827964451550785 4410 3152970 SGTC_1147 3809-1045 12.3 µM -1.38767666900377 0.0755432453412476 no 3073 0.0826177617739316 4424 325925 SGTC_2675 theaflavin digallate 100 µM -1.39065600696622 0.0750944998277844 no 3074 0.0821648820192934 4364 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1029 k015-0030 64.7 µM -1.39355640755462 0.074659599298488 no 3075 0.0817258000605693 4445 2208316 SGTC_1852 st056254 31.4 µM -1.39358577444995 0.0746552057302102 no 3076 0.0817213633674553 4393 442583 SGTC_497 capsazepine 133 µM -1.39578996521159 0.0743260006094446 no 3077 0.0813888765375516 4382 2733484 A calcium channel blocker. SGTC_402 epigallocatechin gallate 10 µM -1.40172022690684 0.0734457946438222 no 3078 0.080499404046092 4385 65064 An antioxidant. SGTC_300 r073-0011 5.04 µM -1.40461120407038 0.0730195988634412 no 3079 0.0800684615616346 4446 2735780 SGTC_3001 9076041 71.4286 µM -1.40803323304263 0.0725175632480652 no 3080 0.0795606147889311 4445 16004211 SGTC_2656 pseudo-anisatin 100 µM -1.41070930889622 0.0721268098370947 no 3081 0.0791651725075839 4505 6708809 A neurotoxin. SGTC_801 0866-0028 10.1 µM -1.41733772724959 0.0711658969925579 no 3082 0.0781921049254228 4473 6849771 SGTC_1017 4239-0030 168 µM -1.41958036212793 0.070843020339165 no 3083 0.077864942949756 4461 1149593 SGTC_1300 1094-0077 113 µM -1.41979136125574 0.0708127003876747 no 3084 0.0778342153429317 4420 5532636 SGTC_1984 st072354 53.1 µM -1.41986881894106 0.0708015724491682 no 3085 0.0778229375618285 4320 5762938 SGTC_3350 9150499 3.57 µM -1.42274304191413 0.0703895971614628 no 3086 0.0774053291454776 4459 4910996 YPR165W RHO1 SGTC_931 2812-0076 566 µM -1.42632479511955 0.0698787908786857 no 3087 0.0768873053097094 4370 3450959 SGTC_1962 st076595 64.5 µM -1.43084807492843 0.0692377919534103 no 3088 0.0762368807073103 4426 279619 SGTC_1027 k015-0025 8.67 µM -1.43286623416786 0.0689532620127643 no 3089 0.0759480342385925 4421 3598955 SGTC_528 3492-0019 172 µM -1.43466286777109 0.0687007229168303 no 3090 0.0756915951442684 4463 2869262 SGTC_1485 3909-9022 254 µM -1.43521983142098 0.0686225797816136 no 3091 0.0756122320764381 4521 714516 SGTC_605 1315-0399 119 µM -1.43788974386624 0.0682489372466545 no 3092 0.0752326700930456 4529 24020461 SGTC_2083 5306046 65.942 µM -1.43962758875325 0.0680065783527066 no 3093 0.0749863949434025 4445 539837 SGTC_2595 hexamethylquercetagetin 100 µM -1.44365651456307 0.0674472629460616 no 3094 0.0744178096328085 4455 386331 SGTC_638 3970-0837 4.09 µM -1.45009294863317 0.0665611104472746 no 3095 0.0735163006023916 4448 4118451 YLR208W SEC13 SGTC_61 0978-8327 98.565 µM -1.45046318153964 0.0665104131005019 no 3096 0.073464699629613 4389 6150059 YHR072W ERG7 SGTC_1168 k815-0004 80.5 µM -1.45140964857058 0.0663809457925704 no 3097 0.0733329123103836 4460 642433 SGTC_2008 4012253 172 µM -1.45142843373173 0.0663783781450999 no 3098 0.0733302984711589 4451 603940 SGTC_2049 5262831 67.185 µM -1.45292468647909 0.0661741099212332 no 3099 0.0731223329541386 4422 763417 SGTC_2323 6148992 148.28 µM -1.45361331560644 0.0660802621315004 no 3100 0.0730267715569459 4421 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_55 0767-0285 6.563 µM -1.45370184641267 0.066068204455466 no 3101 0.0730144930311021 4389 3116166 SGTC_2446 5162541 200 µM -1.4578448651519 0.0655058397204832 no 3102 0.0724416543170396 4450 1549321 SGTC_1280 0880-0253 10.1 µM -1.45881569423708 0.065374599791697 no 3103 0.07230792090685 4452 6836607 SGTC_900 1112-0045 141 µM -1.45956107172378 0.0652739756461077 no 3104 0.0722053722991079 4362 56211 YIL048W NEO1 SGTC_1521 st012942 49.4 µM -1.4595840802901 0.0652708714585543 no 3105 0.0722022085681635 4402 24207259 SGTC_2059 5238311 157 µM -1.46189904291694 0.0649591346559713 no 3106 0.0718844386517743 4438 703021 SGTC_1439 4092-1168 46 µM -1.46343941822929 0.064752346299668 no 3107 0.0716735896353341 4478 2886240 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.46398976903259 0.0646785882850975 no 3108 0.0715983718902869 4513 688664 SGTC_2099 5377090 177.372 µM -1.46613695870328 0.0643914456724693 no 3109 0.0713054893936779 4480 2243829 SGTC_1615 st002656 86.5 µM -1.46710037211909 0.0642629312352319 no 3110 0.0711743764685134 4479 1584458 SGTC_2671 danthron 100 µM -1.46832439040148 0.0640999410690856 no 3111 0.0710080643722182 4475 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_992 3909-8734 162 µM -1.47076083677169 0.0637764608264562 no 3112 0.070677903555853 4491 4288319 SGTC_3303 9125618 40.5795 µM -1.47524084159576 0.0631849787153935 no 3113 0.0700739024003035 4473 22695467 SGTC_703 3875-0075 71.8 µM -1.47625205488469 0.0630520638897361 no 3114 0.0699381199612104 4516 2850814 SGTC_3065 9113888 49.47 µM -1.47733456182162 0.0629100196088444 no 3115 0.0697929889072321 4497 16648368 SGTC_2931 9014674 55.67 µM -1.47795333114797 0.0628289380514147 no 3116 0.0697101350568205 4434 2996810 SGTC_3154 9100113 49.47 µM -1.47895986289214 0.0626972193275973 no 3117 0.0695755212018972 4464 25237525 SGTC_2778 tioconazole 65.09 nM -1.4816901267402 0.0623410097860358 no 3118 0.069211382689855 4375 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2305 7443522 69.23 µM -1.48642636170467 0.0617268329791572 no 3119 0.0685831906332713 4384 5415886 SGTC_244 nsc-207895 1.295 µM -1.48799274751154 0.0615247528601264 no 3120 0.0683764031382679 4270 42640 SGTC_1466 k213-0079 57.5 µM -1.49063029632556 0.0611856494442871 no 3121 0.0680292928022986 4473 3657981 SGTC_836 0330-0104 1.35 µM -1.49242240735744 0.0609560765384983 no 3122 0.0677942222355918 4514 46494820 SGTC_1836 st055642 81 µM -1.49641695383513 0.0604467909726853 no 3123 0.0672725171150195 4483 8571 SGTC_947 3447-0010 211 µM -1.4989869876929 0.0601208881692258 no 3124 0.0669385038979253 4449 748350 SGTC_3116 9124943 49.47 µM -1.49957339654409 0.0600467195025121 no 3125 0.0668624716030946 4470 41905195 YPL160W CDC60 SGTC_2320 7373003 200 µM -1.50082667548551 0.059888445683357 no 3126 0.0667001986158341 4478 5415828 SGTC_3283 9109332 35.8195 µM -1.50168991042694 0.0597796198367107 no 3127 0.066588605410196 4323 17027281 SGTC_976 1348-1067 47.6 µM -1.50219755524962 0.0597156947154106 no 3128 0.0665230480146334 4513 5310671 YGL099W LSG1 SGTC_1709 st033179 39.1045 µM -1.50429631309593 0.0594519771350102 no 3129 0.0662525439911555 4500 573381 SGTC_1732 st034308 51.822 µM -1.50589535920831 0.0592516638366789 no 3130 0.0660470190459818 4380 830119 SGTC_250 brefeldin a 552.239 µM -1.50858028078732 0.0589165131977899 no 3131 0.0657030382861051 4414 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_531 3788-1495 174 µM -1.50901704693562 0.0588621339416614 no 3132 0.0656472132360131 4489 2896655 SGTC_3171 9103192 49.47 µM -1.51139806720948 0.0585663790106397 no 3133 0.0653435307511449 4581 13018434 SGTC_853 0419-0306 21 µM -1.51672156237949 0.0579093497315525 no 3134 0.0646684989619119 4512 762713 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.52804228914596 0.0565314073343007 no 3135 0.0632510192957628 4530 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1610 st001799 48.1 µM -1.52841237607294 0.0564868008468253 no 3136 0.0632050919825047 4468 621897 SGTC_1337 1486-1011 40.3 µM -1.53322581430008 0.0559091613703362 no 3137 0.0626101129719859 4510 X1337 SGTC_2962 9082311 13.18 µM -1.54493049446982 0.0545239734753733 no 3138 0.0611815382151734 4487 16459453 SGTC_1626 st003712 1.76 µM -1.54786319918815 0.0541811905514834 no 3139 0.0608276182679672 4521 24207035 SGTC_1161 k007-0610 110 µM -1.55594257587691 0.0532456662930132 no 3140 0.0598608739845158 4456 5843850 SGTC_3161 9100388 49.47 µM -1.56009886142303 0.0527694159146274 no 3141 0.0593682602971942 4602 25236368 SGTC_1933 st074711 15.9 µM -1.56483608759593 0.0522307261363671 no 3142 0.0588106738476014 4506 17250958 SGTC_1341 1486-1360 280 µM -1.56813088810775 0.051858642387894 no 3143 0.0584252946540223 4532 3976547 SGTC_3307 9126885 69.2785 µM -1.56961655346417 0.0516915558591911 no 3144 0.0582521725364043 4502 24824909 SGTC_1245 0418-0076 17.2 µM -1.57342458732078 0.0512652362732126 no 3145 0.0578102687458322 4540 6790114 SGTC_2759 disulfiram 3.38 µM -1.57378284102682 0.0512252731929663 no 3146 0.0577688311507897 4441 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2715 st079500 56.4 µM -1.57518899711368 0.0510686564694645 no 3147 0.0576064130767294 4526 28246688 SGTC_2126 5251174 33.877 µM -1.57812034570997 0.0507433901999403 no 3148 0.0572689824663746 4509 790722 SGTC_325 2810-4341 181 µM -1.57876604528607 0.0506719647256718 no 3149 0.057194864766008 4528 774970 SGTC_2571 chrysanthemic acid 100 µM -1.58133860909533 0.0503881896247462 no 3150 0.0569003180929432 4518 2743 An insecticide. SGTC_2614 arthonioic acid 13.39 µM -1.58710146365328 0.0497570947095129 no 3151 0.0562448332316595 4411 6710684 SGTC_1909 st060837 51.5 µM -1.58712116471954 0.0497549480955627 no 3152 0.0562426026261799 4479 678937 SGTC_3075 9116269 49.47 µM -1.5909109590447 0.0493433870272304 no 3153 0.0558148079355184 4545 17015205 YNL244C SUI1 SGTC_2331 7980721 200 µM -1.59591406678313 0.0488042311378144 no 3154 0.0552539902341376 4514 2981221 SGTC_709 3807-1509 243 µM -1.60404539481273 0.0479380195837298 no 3155 0.0543520234151963 4614 1886677 YPL242C IQG1 SGTC_1034 k072-0165 12.7 µM -1.60438143257689 0.0479024887823525 no 3156 0.0543150005876595 4557 5835461 SGTC_178 4092-0806 87.505 µM -1.60633192503729 0.0476966704635807 no 3157 0.0541004997063185 4435 2169044 SGTC_827 3253-0474 693 µM -1.61588853100319 0.0466984605459457 no 3158 0.0530592078675279 4556 5402065 SGTC_59 0330-0160 1.33 µM -1.61592262445015 0.0466949296447788 no 3159 0.053055521685494 4503 4293482 SGTC_375 3970-0961 9.27 µM -1.62194715656751 0.0460743521233512 no 3160 0.0524073316443294 4531 2898222 SGTC_2824 7998404 51.95 µM -1.62727465910002 0.0455311100131782 no 3161 0.0518393887111595 4539 837851 SGTC_2936 9038235 15.59 µM -1.63066734461259 0.0451878524709674 no 3162 0.051480265308025 4481 4749415 SGTC_2353 9059630 146.67 µM -1.6328942540548 0.0449636772887436 no 3163 0.0512456194184859 4597 4779114 SGTC_666 0272-0154 136 µM -1.63429944370111 0.0448226830142042 no 3164 0.0510979952231178 4567 6870312 SGTC_3103 9120822 49.47 µM -1.63613032479286 0.0446395099146527 no 3165 0.0509061573810468 4566 17141819 SGTC_2844 9010103 25.97 µM -1.64289891631444 0.0439675650953925 no 3166 0.0502019246462242 4518 2480525 SGTC_2357 9067248 200 µM -1.64649258653673 0.0436141362529225 no 3167 0.0498311925711228 4521 9150235 SGTC_2304 7443016 91.4 µM -1.651070442585 0.0431672394817333 no 3168 0.0493620959409224 4522 939854 SGTC_2860 9025725 38.96 µM -1.65278595211635 0.0430007246922573 no 3169 0.0491872170447501 4605 40546248 SGTC_1237 0330-0133 46.1 µM -1.65779037778316 0.0425179368258954 no 3170 0.0486798920765166 4516 X1237 YHR072W ERG7 SGTC_1256 0570-0116 285 µM -1.66699799341382 0.0416411153910816 no 3171 0.047757401935216 4561 410638 SGTC_2108 5365811 200 µM -1.66863787723889 0.041486500281255 no 3172 0.0475945837722195 4576 780283 SGTC_1265 0819-1001 68.8 µM -1.66929053148256 0.0414250948617838 no 3173 0.0475299078982777 4521 3106768 SGTC_42 0133-0086 60.653 µM -1.67453845222112 0.0409340136159954 no 3174 0.0470124119372909 4475 162923 Model of phenazepam hydroxylation. SGTC_3293 9120939 62.045 µM -1.67480935493589 0.0409087922567923 no 3175 0.0469858214135768 4560 934087 SGTC_1986 st071812 45 µM -1.68126664257639 0.040311333560781 no 3176 0.0463555670449778 4539 11838594 SGTC_2731 amoxapine 43.43 µM -1.68301726531365 0.0401505844738628 no 3177 0.0461858745786319 4725 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2205 7238770 200 µM -1.68414074677028 0.0400476965909357 no 3178 0.0460772356268776 4613 279867 SGTC_203 k066-0004 30.888 µM -1.69357150448744 0.0391924541895106 no 3179 0.0451733683351876 4630 6795412 SGTC_2700 st077718 96.8 µM -1.69542450385314 0.0390261721173677 no 3180 0.0449974603801619 4556 904970 SGTC_324 1315-0088 19.6 µM -1.69792577809402 0.0388026274262427 no 3181 0.0447608856204027 4565 6787421 SGTC_3304 9125678 46.087 µM -1.69953506721506 0.0386593537096931 no 3182 0.0446092065413868 4534 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2071 5230951 39.92 µM -1.71045969546174 0.0376981001452336 no 3183 0.0435904501825127 4628 1799272 SGTC_1802 st050112 57.9 µM -1.71707055561669 0.0371259500886275 no 3184 0.0429831406526488 4608 4662563 SGTC_3290 9121031 71.43 µM -1.7199463631307 0.0368792823582616 no 3185 0.0427210959092158 4604 17014854 SGTC_3332 9141069 11.198 µM -1.73067549166656 0.0359708081278966 no 3186 0.041754829420423 4545 17332883 SGTC_767 0929-0023 86 µM -1.73540360761113 0.0355763219409222 no 3187 0.0413346707719765 4627 1204563 SGTC_2868 9035608 32.47 µM -1.73732078444237 0.0354173778277441 no 3188 0.0411652824368328 4590 6462614 SGTC_2405 ticlatone 3.52 µM -1.73929521382463 0.0352542963055923 no 3189 0.0409914243870399 4409 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_548 1436-0017 110 µM -1.74007262533352 0.0351902538579407 no 3190 0.0409231331627615 4636 9677137 SGTC_2113 5491891 107.031 µM -1.75093004748969 0.0343057627974237 no 3191 0.0399789801364317 4594 789979 SGTC_1221 2958-7315 257 µM -1.75633275496891 0.0338724911098681 no 3192 0.0395158037540688 4640 4562705 SGTC_2112 5488546 200 µM -1.76009473639563 0.0335734642902871 no 3193 0.0391958725501152 4577 600757 SGTC_1910 st062352 60.4 µM -1.76232110146976 0.0333975240396264 no 3194 0.0390075303056742 4536 2245730 SGTC_1121 fusaric acid 630.51 nM -1.76609049006653 0.0331013762850527 no 3195 0.038690334342314 4584 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1159 4092-0538 61.2 µM -1.77302207215446 0.0325624342015137 no 3196 0.0381125247558389 4636 717301 SGTC_62 0180-0423 3.232 µM -1.77357158529954 0.0325200200657612 no 3197 0.0380670206132444 4564 30102 YGL099W LSG1 SGTC_995 3931-2021 34.6 µM -1.77581804275603 0.0323471010945844 no 3198 0.0378814564217533 4610 730143 SGTC_1504 k297-0033 30 µM -1.77833298314195 0.0321544167857974 no 3199 0.0376745911490225 4533 4388117 SGTC_1465 k213-0056 144 µM -1.77939336265093 0.0320734593587379 no 3200 0.0375876469411069 4547 24048857 YMR208W ERG12 SGTC_2674 ligustilide 100 µM -1.78530608057926 0.0316251174942825 no 3201 0.0371058415577226 4656 5319022 A signalling regulator. SGTC_105 0111-0055 734.78 µM -1.78626714629196 0.0315527347296345 no 3202 0.037028006851835 4620 5179370 SGTC_383 2324-0395 7.37 µM -1.78716038232147 0.0314855833937867 no 3203 0.0369557852382232 4595 3146421 SGTC_2437 5741531 144.16 µM -1.78727635996316 0.0314768731455564 no 3204 0.0369464164464334 4626 2262990 SGTC_2268 7933382 153.85 µM -1.78917700133666 0.0313344132024588 no 3205 0.036793157164523 4648 935025 YOR257W CDC31 SGTC_1202 1988-0068 29.6 µM -1.79384871440186 0.0309865160724279 no 3206 0.0364186595538499 4601 2850480 SGTC_2352 9027995 87.8 µM -1.79655226604239 0.0307866499610345 no 3207 0.036203364086015 4592 2997347 SGTC_775 4577-0580 57.3 µM -1.79832342039131 0.0306562929229052 no 3208 0.036062885207617 4619 2006902 SGTC_2124 5246320 200 µM -1.79888798495994 0.0306148371390491 no 3209 0.0360182007820907 4605 579342 SGTC_1471 k673-0312 37 µM -1.79909275268393 0.0305998125928215 no 3210 0.0360020049394825 4637 24099884 SGTC_1190 1486-1332 13 µM -1.79970778450566 0.0305547222026395 no 3211 0.0359533956405885 4636 4150046 SGTC_1082 camptothecin 424.86 nM -1.80989974462169 0.0298154878508673 no 3212 0.0351556678800696 4509 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2091 4-phenylthiadiazole 200 µM -1.81213705537967 0.0296552149557417 no 3213 0.0349825110027624 4643 270010 SGTC_2296 7971656 126.45 µM -1.81694361279005 0.0293133076455369 no 3214 0.034612873888018 4624 666570 SGTC_3099 9120367 49.47 µM -1.81868049672271 0.0291905649841125 no 3215 0.0344800944532092 4653 24824940 SGTC_838 0109-0203 71.4 µM -1.82019030047124 0.029084216838285 no 3216 0.034365014854122 4656 759422 SGTC_1931 st074438 57.1 µM -1.82968656747753 0.0284226713257328 no 3217 0.0336484103194547 4636 2787313 SGTC_413 propylparaben 100 µM -1.83418613707447 0.0281136136366378 no 3218 0.0333131842692675 4627 7175 A pharmaceutical preservative. SGTC_954 1189-0853 2.85 µM -1.8386829392423 0.027807546622812 no 3219 0.0329809171063026 4590 2828194 SGTC_2922 7999257 32.47 µM -1.85171071811128 0.0269364684751132 no 3220 0.0320336870485284 4617 2988377 SGTC_2600 tangeritin 87.95 µM -1.86515382831498 0.026061618338922 no 3221 0.0310799226422686 4577 68077 A bioactive flavone. SGTC_579 4491-1009 110 µM -1.86693484928915 0.0259475160323332 no 3222 0.0309553432604722 4680 1271041 SGTC_714 4296-0578 26.1 µM -1.86823377961242 0.0258645629909978 no 3223 0.0308647461397547 4682 1589775 SGTC_2400 5203494 178.7 µM -1.86889583552647 0.0258223678396784 no 3224 0.0308186539135441 4560 6777674 SGTC_582 0987-0078 156 µM -1.87209961433952 0.0256189927670501 no 3225 0.0305964116782138 4676 1625765 SGTC_1609 st001574 46.4 µM -1.87469432556468 0.0254552655576051 no 3226 0.0304173939975817 4637 3960012 SGTC_1240 0356-0016 42.1 µM -1.87583330625784 0.0253836727311513 no 3227 0.0303390864942963 4622 4305613 SGTC_2773 thioridazine 9.09 µM -1.88476726383281 0.0248279411558959 no 3228 0.0297306332503645 4642 5452 An antipsychotic. SGTC_789 1309-1135 70.6 µM -1.88549279339043 0.0247832615022896 no 3229 0.0296816682520404 4633 3092424 SGTC_520 3584-0023 682 µM -1.8878620051338 0.0246378298425049 no 3230 0.0295222392265312 4621 1340790 SGTC_1571 st070080 73.4 µM -1.89041211135879 0.0244820950107101 no 3231 0.0293514324348388 4637 4315245 SGTC_1126 isoteolin 1.0172 µM -1.90381202236847 0.0236772791102082 no 3232 0.0284673351042174 4602 133323 SGTC_924 2046-0044 21.3 µM -1.90951513497496 0.0233415553195487 no 3233 0.0280978355945812 4640 3623589 SGTC_2984 9022109 38.96 µM -1.91697940087195 0.0229082189885558 no 3234 0.0276202743298545 4656 6459207 SGTC_2406 ethylparaben 405.7 µM -1.91841472183656 0.0228256734135827 no 3235 0.0275292229046558 4611 8434 A possible steroid mimic. SGTC_1819 st053448 58.6 µM -1.91885422284533 0.0228004478031087 no 3236 0.0275013926874141 4627 2857616 SGTC_1425 4048-4433 7.33 µM -1.92441195142679 0.0224834778871027 no 3237 0.0271514837832573 4721 23734946 SGTC_36 0335-0881 14.2 µM -1.9296510728675 0.0221880893073891 no 3238 0.0268250430388489 4586 23828853 SGTC_2344 7990960 76.95 µM -1.93081384419329 0.0221229766768938 no 3239 0.0267530388383824 4638 140813 SGTC_1746 st038117 42 µM -1.93263991904865 0.0220210460440066 no 3240 0.0266402856193425 4671 2898218 SGTC_106 0092-0003 11.579 µM -1.93297102723918 0.0220026062679796 no 3241 0.0266198835126987 4627 1072148 SGTC_2884 9058502 51.95 µM -1.93472691467484 0.0219050367069541 no 3242 0.0265119078812465 4653 6471554 SGTC_3138 9097216 49.47 µM -1.93898077449255 0.0216701758124441 no 3243 0.0262518396106417 4618 25237486 SGTC_1597 7-benzyloxygramine 47.5 µM -1.94497546611052 0.0213428157864336 no 3244 0.0258889655866268 4567 260807 SGTC_707 0865-0008 204 µM -1.94833181204844 0.0211613642598513 no 3245 0.025687636518642 4711 723043 SGTC_2726 cimetidine 79.27 µM -1.94865721345784 0.0211438419344935 no 3246 0.0256681873257606 4695 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_355 1311-2252 105 µM -1.95114279329102 0.0210104021246981 no 3247 0.0255200309333796 4640 5338538 SGTC_107 0358-0022 2.6945 µM -1.95578789217823 0.0207629372683744 no 3248 0.0252450728901764 4696 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2104 5389443 200 µM -1.9772771055289 0.0196499940769081 no 3249 0.0240051580452442 4682 2244536 SGTC_2251 lansoprazole 556 µM -1.97776321216125 0.019625415814118 no 3250 0.0239777127018476 4667 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2776 terbinafine 19.92 µM -1.97925596853737 0.0195501029703855 no 3251 0.0238935971690211 4670 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1952 st077036 64.1 µM -1.99548259796579 0.0187471490670238 no 3252 0.022995135130013 4685 2937007 SGTC_2053 5265679 138 µM -2.00066426228593 0.0184967266612124 no 3253 0.0227142916006431 4595 764595 SGTC_3082 9117008 49.47 µM -2.00870908939325 0.0181135781083664 no 3254 0.0222839971076832 4695 41448529 SGTC_420 mitomycin C 81.9 mM -2.01255668344348 0.0179327345227238 no 3255 0.0220806439111617 4671 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1949 st076024 69.1 µM -2.02176667385364 0.0175060929899971 no 3256 0.0216002310880256 4651 2921930 SGTC_1015 4130-4525 82 µM -2.02727195821352 0.0172552289025465 no 3257 0.0213173038225705 4679 1363237 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -2.02907047985113 0.0171739424656014 no 3258 0.021225556075316 4691 688667 SGTC_2943 9068529 45.32 µM -2.02975284778035 0.0171431877285054 no 3259 0.0211908340342431 4645 3270634 SGTC_1958 st076513 41.9 µM -2.03128084789177 0.0170744904874586 no 3260 0.0211132565309935 4638 732122 YGL099W LSG1 SGTC_698 k064-0052 127 µM -2.0315152176671 0.017063974314869 no 3261 0.0211013787133777 4744 5088751 SGTC_731 3966-0296 387 µM -2.04119214622365 0.0166345775819802 no 3262 0.0206158660271319 4708 660956 SGTC_2775 cyproheptadine 69.59 µM -2.04312665694813 0.0165498551197065 no 3263 0.0205199508558515 4688 2913 A selective serotonin reuptake inhibitor. SGTC_2785 7756463 72.73 µM -2.04378411926401 0.0165211455791564 no 3264 0.0204874393513758 4673 2201551 SGTC_2923 7992654 58.14 µM -2.04628244398666 0.0164124391789435 no 3265 0.0203642949812195 4653 2985126 SGTC_2949 9072542 2.23 µM -2.04867580281162 0.0163088749755964 no 3266 0.0202469134156427 4654 16457352 SGTC_1164 k060-0068 93.7 µM -2.0636292292438 0.0156744083740098 no 3267 0.0195264420303013 4702 5963676 SGTC_1601 4'-hydroxyflavanone 55.5 µM -2.07135757778039 0.0153548809711093 no 3268 0.0191626961093796 4711 165506 SGTC_1218 1348-1416 30.7 µM -2.08263412005549 0.0148986963485387 no 3269 0.0186422933292983 4691 6787668 SGTC_2587 piperic acid 92.2 µM -2.09896971551213 0.0142585418123826 no 3270 0.0179097852291957 4656 5370536 SGTC_614 0462-0418 107 µM -2.1030018154844 0.0141042282841175 no 3271 0.0177328053958284 4525 5188303 SGTC_602 3130-1533 38.1 µM -2.13782623576835 0.0128303108222233 no 3272 0.016265424416658 4726 720941 SGTC_2382 9035899 200 µM -2.14135629500898 0.012706912909934 no 3273 0.0161226582826655 4708 6462679 SGTC_2777 climbazole 1.536 µM -2.14677050333828 0.0125196476940288 no 3274 0.0159057783532992 4506 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2284 7945075 39.21 µM -2.15995026818578 0.0120737479838511 no 3275 0.0153882598494978 4671 1245402 SGTC_1959 st077091 55.8 µM -2.16040000932907 0.012058778362705 no 3276 0.0153708583677108 4705 821356 YKL052C ASK1 SGTC_2666 tannic acid 100 µM -2.1606752576545 0.0120496246702846 no 3277 0.01536021673697 4704 16134267 A thiamine antagonist. SGTC_1944 st076371 56.9 µM -2.17218177271681 0.0116723147330829 no 3278 0.0149209774808109 4705 24208455 SGTC_2846 9008642 19.48 µM -2.17240478351471 0.0116651044670411 no 3279 0.0149125722634889 4702 2992898 SGTC_1594 piperine 70.1 µM -2.17533878975655 0.0115706032001797 no 3280 0.014802368878073 4707 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2601 securinine 100 µM -2.19357232443815 0.0109980922375141 no 3281 0.0141330849229972 4687 442872 A GABA receptor antagonist. SGTC_721 1187-1332 279 µM -2.19492198851304 0.01095671129122 no 3282 0.0140845971107966 4732 25730 SGTC_349 k015-0014 24 µM -2.20849695918856 0.0105479773045365 no 3283 0.0136048247755301 4720 2196908 SGTC_393 acivicin 6.25 µM -2.21344119244949 0.0104024447126997 no 3284 0.0134336216913085 4622 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_3274 9138298 49.47 µM -2.2181417486879 0.0102657108494898 no 3285 0.0132725845105046 4706 17015756 SGTC_2865 9030313 51.95 µM -2.22191884469723 0.0101569777388121 no 3286 0.0131443953121419 4710 42562754 SGTC_825 1988-2224 89.6 µM -2.22321204874395 0.0101199812247756 no 3287 0.0131007523806155 4720 1180859 SGTC_2956 9076196 2.52 µM -2.22858341645529 0.00996757047330988 no 3288 0.0129208177336129 4712 16423868 SGTC_3210 9128157 49.47 µM -2.24389951044835 0.00954393206270908 no 3289 0.0124194338317926 4665 17590849 SGTC_906 1165-0455 526 µM -2.26679651035733 0.00893997181922272 no 3290 0.0117013297052448 4719 3252859 SGTC_3094 9117742 49.47 µM -2.26794925085659 0.00891047138217655 no 3291 0.011666150004409 4705 17149698 SGTC_1578 josamycin 24.2 µM -2.27186255873923 0.00881095902698152 no 3292 0.0115474064682364 4738 5282165 A P450 substrate. SGTC_719 2810-4230 27.3 µM -2.29083715821649 0.00834213876641025 no 3293 0.0109864168244784 4754 721079 SGTC_2787 5284540 71.43 µM -2.29362547455634 0.00827512457415777 no 3294 0.0109060104167361 4730 736958 SGTC_1429 4049-0205 9.46 µM -2.30615615513898 0.00797976594755064 no 3295 0.0105509542430752 4771 22774478 SGTC_677 0929-0063 136 µM -2.31721912990721 0.00772674797998194 no 3296 0.0102458989815514 4766 1539583 SGTC_3351 9150312 21.596 µM -2.33281290058815 0.00738210540087088 no 3297 0.00982898364701446 4698 4904905 SGTC_2784 7567673 72.73 µM -2.33389403414785 0.0073587210871922 no 3298 0.00980063560839128 4684 3471247 SGTC_583 1488-1091 88.9 µM -2.33478813946681 0.00733943143910131 no 3299 0.00977724555098541 4781 4303273 SGTC_3077 9117319 49.47 µM -2.34036153434358 0.00722019143977847 no 3300 0.00963254031384059 4713 17154678 SGTC_2673 kobusone 100 µM -2.35299859752366 0.00695613626730053 no 3301 0.00931135216444017 4786 6710676 An epoxy ketone and protein crosslinker. SGTC_3129 9127257 49.47 µM -2.40566408716236 0.00594525193914582 no 3302 0.00807155028145627 4708 837894 SGTC_35 0133-0054 64.071 µM -2.42559493396744 0.00559808248681058 no 3303 0.0076416589624207 4706 99677 SGTC_2194 5927483 104.545 µM -2.4261651760418 0.00558842020740979 no 3304 0.00762966173619914 4774 760979 SGTC_516 3992-2719 87.3 µM -2.42893090126827 0.00554176711016099 no 3305 0.00757170907715318 4682 5350887 YDR037W KRS1 SGTC_3088 9117578 49.47 µM -2.55082329835496 0.00380010757457668 no 3306 0.00537343987572778 4785 678341 SGTC_288 1315-0019 35.1 µM -2.56842307506811 0.00359408241400172 no 3307 0.00510811920264564 4773 6811474 SGTC_1022 4477-0945 21.3 µM -2.6087514922774 0.0031593182399916 no 3308 0.00454366045683396 4740 4648966 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -2.62126368715448 0.00303439461212414 no 3309 0.00438022367818014 4764 6312947 SGTC_2890 9046729 58.44 µM -2.62322296833297 0.00301524096442418 no 3310 0.00435511244429832 4768 903329 SGTC_733 4069-0007 56.1 µM -2.63422122333526 0.00290973133668036 no 3311 0.00421652614536088 4760 5717425 YNL287W SEC21 SGTC_664 1222-0054 14.9 µM -2.66099942579704 0.00266662200428189 no 3312 0.00389545449931717 4766 6813991 SGTC_1816 st051957 91.6 µM -2.67831775619563 0.00251932287598237 no 3313 0.00369964929343319 4785 674121 SGTC_2051 5263410 176 µM -2.68635244933553 0.00245351624349734 no 3314 0.00361184227664472 4748 227584 SGTC_711 k292-0785 179 µM -2.68962939686932 0.00242712637797517 no 3315 0.00357657045861501 4737 4146315 SGTC_633 0437-0093 97.7 µM -2.69239397241375 0.00240506274766708 no 3316 0.00354705441688465 4749 2831118 SGTC_796 1234-0020 70.7 µM -2.70863726341098 0.00227905397320699 no 3317 0.00337800795758927 4757 46495034 SGTC_75 0159-0059 199.013 µM -2.7147704601993 0.00223305199251293 no 3318 0.00331608605846498 4765 5377270 SGTC_2127 5253358 187.912 µM -2.72747758347568 0.00214040943730657 no 3319 0.00319102968950155 4752 20612 SGTC_1025 k007-0731 70 µM -2.75615028415165 0.00194404395705915 no 3320 0.00292430589759322 4771 6256118 SGTC_2128 5255449 168.493 µM -2.77862360542491 0.00180173565339225 no 3321 0.00272948698186003 4744 736008 SGTC_2817 7995342 71.43 µM -2.77900531540251 0.0017994025761415 no 3322 0.00272628164334982 4769 18879975 SGTC_678 1218-2179 85.9 µM -2.86598977350333 0.00133404339597721 no 3323 0.00207853837223874 4803 6820081 YOR116C RPO31 SGTC_3130 9127414 49.47 µM -2.86781716167204 0.00132557087187885 no 3324 0.00206657155342256 4789 1494646 SGTC_667 1498-1044 59 µM -2.89679131070612 0.00119764470677267 no 3325 0.00188500223454662 4785 6739982 SGTC_681 1642-0006 26.6 µM -2.90777043013725 0.00115219789030515 no 3326 0.00182007727472469 4796 4446530 SGTC_1415 3966-0071 78.1 µM -2.91624088234028 0.00111822090829898 no 3327 0.00177138431129255 4758 2893185 SGTC_688 0527-0193 473 µM -2.96309244937612 0.000946314404795016 yes 3328 0.00152282540048965 4790 4007154 SGTC_1957 st077035 62.4 µM -3.04588436976402 0.000700628034476024 yes 3329 0.00115998518175333 4791 705593 SGTC_2020 4017018 200 µM -3.09265023061536 0.000589335555292813 yes 3330 0.000991888978805427 4791 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2449 5812982 45.77 µM -3.13007259889303 0.000512302553954209 yes 3331 0.000873815531961357 4769 776185 SGTC_386 1509-0011 3.07 µM -3.23304561323355 0.000345791216162357 yes 3332 0.000612390026014539 4795 3107280 SGTC_2581 avocatin a 64 µM -3.27544957652723 0.00029315665440523 yes 3333 0.000527469723362921 4777 6710728 A skin care supplement. SGTC_1947 st076332 61.6 µM -3.29296846525225 0.000273671877469857 yes 3334 0.000495677964776194 4778 24208416 SGTC_3159 9100096 49.47 µM -3.3387590426257 0.000228291805963108 yes 3335 0.000420767632265577 4781 25236875 SGTC_661 1304-0007 33.6 µM -3.34167327312031 0.000225655762858319 yes 3336 0.000416375107615065 4802 3117130 SGTC_2654 protoveratrine a 100 µM -3.48558810939295 0.000125743895316325 yes 3337 0.000245528238036743 4806 5702278 A heart drug and vasodilator. SGTC_1016 4226-1401 38 µM -3.54241020815803 9.92156204242749e-05 yes 3338 0.000198244190447577 4795 2901613 SGTC_1926 methyl fluorone black 53.6 µM -3.64577921366366 6.39056980737669e-05 yes 3339 0.000133291393558083 4706 72721 Reacts with homocysteine. SGTC_660 4031-1742 102 µM -3.75792141222872 3.91449431029035e-05 yes 3340 8.56653345560894e-05 4790 6738706 SGTC_1821 st053465 65.6 µM -3.79732467650846 3.28468305058185e-05 yes 3341 7.31330791225434e-05 4803 675086 SGTC_741 4582-0002 126 µM -3.82755305272798 2.86787327607998e-05 yes 3342 6.47117470343891e-05 4808 2912688 SGTC_3206 9114350 49.47 µM -3.85233905812213 2.56400747474071e-05 yes 3343 5.84974357940509e-05 4777 17087243 SGTC_3204 9114183 49.47 µM -3.91270818317826 1.94648461245964e-05 yes 3344 4.56333992761835e-05 4790 17027248 SGTC_613 3914-0030 117 µM -4.31008662552298 2.87745165612835e-06 yes 3345 8.15953042521523e-06 4757 1145395 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -4.38334392211604 1.9854853386661e-06 yes 3346 5.84356941829416e-06 4796 4330530 SGTC_1943 st076331 65.2 µM -4.49464111825342 1.11742775159557e-06 yes 3347 3.48436882140275e-06 4806 24208415 SGTC_748 act1.228 77.9 µM -4.5802791915446 7.1146881527078e-07 yes 3348 2.32177818196379e-06 4805 4421505 YNR035C ARC35 SGTC_1107 amlodipine 47 µM -4.9940976352215 7.17701256611571e-08 yes 3349 2.95557449425847e-07 4722 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_744 1594-0068 283 µM -5.40987533551516 5.9333341612609e-09 yes 3350 3.1534318330828e-08 4809 668392 SGTC_750 4073-0104 132 µM -8.84925810359307 4.40627076493549e-21 yes 3351 4.40515015805648e-19 4810 22330957