SGTCid condition conc unit JLP1|YLL057C.score JLP1|YLL057C.strain.pval JLP1|YLL057C.strain.significant JLP1|YLL057C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1383 3049-0032 20.7 µM 5.35681001457474 5.68363909066006e-10 yes 1 4.2352052028759e-08 5 712864 SGTC_1332 1480-0653 17.5 µM 4.1377142231627 1.27565238621842e-06 yes 2 1.75391444675197e-05 14 5749438 SGTC_2829 7992743 58.44 µM 3.85035388111267 6.00146800819357e-06 yes 3 5.89736403805031e-05 43 16462845 SGTC_1169 aniline yellow 25.8 µM 3.80785171143464 7.48088305794192e-06 yes 4 7.00896432135289e-05 12 6051 A DNA damaging agent. SGTC_716 1683-5115 658 µM 3.73442663247386 1.08889467478534e-05 yes 5 9.40716633929748e-05 27 723597 SGTC_2693 st077581 40.7 µM 3.68772091173817 1.37779785077328e-05 yes 6 0.000113135813589358 46 25238761 SGTC_2479 5617353 43.85 µM 3.53012768687461 2.98813266088863e-05 yes 7 0.000207679577937371 58 2731746 SGTC_751 0833-0568 350 µM 3.51513408336708 3.21140813629768e-05 yes 8 0.000219766005217905 36 6954252 SGTC_2093 5331342 194.4 µM 3.49667960361838 3.50792258900094e-05 yes 9 0.000235543628912681 33 33839 SGTC_57 miconazole 162.5 nM 3.20122233150771 0.000136267321655213 yes 10 0.000684229484374201 47 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_687 k029-0044 34.9 µM 3.19220806957598 0.000141789060235322 yes 11 0.000705947929465495 46 5829338 SGTC_1177 0983-0204 23.6 µM 3.18958133888763 0.000143437105015086 yes 12 0.000712395187099235 35 766818 SGTC_2711 st079103 59.1 µM 3.17935383714147 0.000150026484535356 yes 13 0.000738018946347822 21 54693780 SGTC_2716 st080858 38.6235 µM 3.15747054172385 0.000165089205372557 yes 14 0.000795721577179384 43 5296050 SGTC_2794 7785382 27.27 µM 3.02885798001133 0.00028628531949905 yes 15 0.00122740026312084 91 2205081 SGTC_3328 9140624 29.0385 µM 2.92986286390277 0.000431394735231761 yes 16 0.00169555812289662 58 4904392 SGTC_1338 1486-1223 76 µM 2.9245317339263 0.000440877739450004 yes 17 0.00172487451783683 65 3444526 SGTC_1705 st027868 56.3335 µM 2.85458402916933 0.000584569479860613 yes 18 0.00215466150592426 53 292948 SGTC_2708 st078559 56 µM 2.79527021800448 0.000739120761759247 yes 19 0.00259281755322846 38 17250902 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 2.75483660296152 0.000865184377531155 yes 20 0.00293607265546344 83 521171 SGTC_1270 0831-1170 17.3 µM 2.7524256236446 0.000873292628660569 yes 21 0.00295777910014772 72 6764716 SGTC_763 3453-1109 128 µM 2.74361004248992 0.000903538311354787 yes 22 0.0030383838594784 80 1560353 SGTC_890 0929-0006 47.2 µM 2.71076837134166 0.00102488647830825 no 23 0.00335637505840147 77 1378169 SGTC_2284 7945075 39.21 µM 2.70584561071641 0.00104431316759319 no 24 0.00340653562737088 100 1245402 SGTC_1397 3532-0190 20.1 µM 2.69859424102094 0.00107354496695205 no 25 0.00348165095720726 40 5322280 SGTC_2057 5236571 38.335 µM 2.69420416421465 0.00109160494318395 no 26 0.00352784653958427 126 54684039 YBR257W POP4 SGTC_1891 st059073 26.2 µM 2.66421777335242 0.00122260217056964 no 27 0.00385837941571953 97 688754 SGTC_3007 9078383 71.4286 µM 2.65921508693558 0.001245807439849 no 28 0.00391614718325917 92 6496995 SGTC_2506 ethyl hematommate 54.16 µM 2.61848980028349 0.00145024213696062 no 29 0.00441599659482207 86 3940691 An allergen. SGTC_2970 9090938 41.86 µM 2.60181009152027 0.00154247576598301 no 30 0.00463665938378005 158 17217104 SGTC_884 0851-0618 334 µM 2.57764177417589 0.00168562798927541 no 31 0.00497385323689797 105 9642473 SGTC_2255 7941087 197.44 µM 2.56368426932372 0.00177371043200961 no 32 0.00517838543859244 119 935561 SGTC_1430 4049-0248 69.1 µM 2.55093773412541 0.00185778760568572 no 33 0.00537167588363586 116 22774488 SGTC_1257 0669-0121 16 µM 2.54806172205668 0.00187725205175861 no 34 0.00541616518963825 122 4307855 SGTC_1927 st060202 13.8 µM 2.53332399299656 0.00197993434053806 no 35 0.00564932330356459 99 688887 SGTC_1422 4031-0024 15.5 µM 2.52626266498405 0.00203091774341296 no 36 0.00576416262636249 94 782427 SGTC_2368 9071271 200 µM 2.49829726821291 0.00224474438208188 no 37 0.00623957492062009 137 27209959 SGTC_23 0213-0011 39.996 µM 2.49770078599946 0.00224951949255827 no 38 0.00625008265294109 108 627608 SGTC_2078 5212016 200 µM 2.48790687374345 0.00232925151926042 no 39 0.00642486878286586 90 1899708 SGTC_863 0466-0191 129 µM 2.48011589102067 0.00239449554879527 no 40 0.00656698434607089 173 765160 YPR165W RHO1 SGTC_1401 3807-4679 7.6 µM 2.43275411858673 0.0028279562506842 no 41 0.00749223631252881 98 3291456 SGTC_998 3996-0085 177 µM 2.42988123981476 0.00285639633923376 no 42 0.00755188547988508 126 715391 SGTC_739 1486-1183 203 µM 2.42897742335627 0.00286539687180224 no 43 0.00757073758344198 108 4346692 SGTC_612 0302-0167 22.4 µM 2.41421384955299 0.00301608384585729 no 44 0.0078846020080992 169 235821 SGTC_2804 7954240 19.48 µM 2.38921904864963 0.00328753947821775 no 45 0.00844211608227338 145 828705 SGTC_1263 0774-1208 64.8 µM 2.37666805774929 0.00343197029573893 no 46 0.00873490065226542 202 906585 SGTC_2103 5378138 10 µM 2.3438132613028 0.00383741321194919 no 47 0.00954386274613223 137 244142 SGTC_2096 5468907 200 µM 2.31181688477973 0.00427299949984115 no 48 0.0103938882665178 119 759785 SGTC_2237 6667747 47.222 µM 2.31052996311972 0.00429140912588742 no 49 0.0104294158290333 113 729940 YDL015C TSC13 SGTC_2340 7987427 183.45 µM 2.30888535649401 0.00431503868544866 no 50 0.01047497189196 156 2239331 SGTC_3313 9133968 57.047 µM 2.30016519469582 0.00444228297427348 no 51 0.0107194314341796 128 1494643 SGTC_2308 7584454 197.62 µM 2.26112596613269 0.00505397556965689 no 52 0.0118757289402956 188 893577 SGTC_2288 7946289 167.31 µM 2.24710826944653 0.00529127043610953 no 53 0.0123165542827116 189 1246052 SGTC_2898 9056270 58.44 µM 2.24658659756847 0.00530028958448423 no 54 0.012333229750124 88 19154699 SGTC_2375 9072683 200 µM 2.23566273261083 0.00549231867260939 no 55 0.0126869359787299 184 16798029 SGTC_618 k072-0232 33.2 µM 2.21288907704566 0.00591264484520714 no 56 0.0134526469718353 138 5872756 YGL099W LSG1 SGTC_1404 3909-7820 48.3 µM 2.19455535443747 0.00627150101798103 no 57 0.0140977545438679 142 23741373 SGTC_2407 paclitaxel 400 µM 2.19057423795657 0.00635192770188638 no 58 0.0142413085580932 207 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_359 0081-0058 15.9 µM 2.17684517878072 0.00663632919014726 no 59 0.0147460604429122 209 3494159 SGTC_2522 biochanin a 4.94 µM 2.168559391652 0.00681336751521818 no 60 0.015058075495369 141 5280373 A possible chelator. SGTC_1339 1486-1321 22.7 µM 2.1280314307857 0.00774076714421792 no 61 0.0166672388492033 200 3469382 SGTC_2052 5265182 7.135 µM 2.12686057934866 0.00776913596324263 no 62 0.0167158345420809 195 1239884 SGTC_1913 st060213 96.1 µM 2.12298684346141 0.00786364668312091 no 63 0.0168774771769591 232 688959 SGTC_130 0136-0219 337.655 µM 2.11714317287622 0.00800813314990094 no 64 0.0171238492839261 190 234244 SGTC_2415 st077333 57.7 µM 2.10983675343921 0.00819206631015323 no 65 0.0174362097564649 282 2766255 SGTC_2891 9063876 19.48 µM 2.10950954687987 0.00820038960268567 no 66 0.0174503114194597 96 6472478 SGTC_2791 5663188 71.43 µM 2.10906607519702 0.00821168223818226 no 67 0.0174694393177077 192 54690634 SGTC_2831 7999036 19.48 µM 2.10686217460393 0.00826800560020678 no 68 0.017564764103067 241 2988270 SGTC_190 3970-0790 3.722 µM 2.10282017880302 0.00837218598002222 no 69 0.0177407457078847 153 2832352 SGTC_2994 9053520 71.4286 µM 2.1024603207378 0.0083815167693856 no 70 0.0177564859899908 186 4647384 SGTC_1938 st074717 56.4 µM 2.10122152511199 0.0084137074483925 no 71 0.0178107623606706 139 17250979 SGTC_1343 1487-0095 224 µM 2.09972630571782 0.00845270592641458 no 72 0.017876462081544 146 4560101 YGL055W OLE1 SGTC_2101 5377231 179.231 µM 2.09489715555975 0.00857974609974903 no 73 0.0180900678904614 155 2844213 SGTC_829 1635-0120 117 µM 2.08691588434634 0.0087933826307739 no 74 0.0184478693880079 224 285054 SGTC_705 1124-0212 310 µM 2.06549044531333 0.00939010282005627 no 75 0.0194383093305189 201 9554485 SGTC_297 0986-0032 24 µM 2.06166921568259 0.00950017124509654 no 76 0.0196196196677591 159 2847425 SGTC_3004 9076122 71.4286 µM 2.05730751201809 0.00962718496914151 no 77 0.0198283276132312 199 44782551 SGTC_3018 9082602 49.47 µM 2.03487203906776 0.0103042308643678 no 78 0.0209318750454188 218 17332089 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 2.02976895775743 0.0104639021426649 no 79 0.0211900148648766 220 688751 SGTC_1634 st006576 41 µM 2.02186825074516 0.0107153623338456 no 80 0.0215949822611136 214 3915356 SGTC_1679 SEC14.276 6.7 µM 2.0132000068734 0.010997289469337 no 81 0.0220467962635513 266 1005053 YMR079W SEC14 SGTC_2504 purpurogallin 52.29 µM 2.00952103035069 0.0111188821560817 no 82 0.0222409533373236 204 5281571 An antioxidant. SGTC_2692 st077426 47.7 µM 2.0088207605603 0.0111421585303368 no 83 0.0222780728715817 221 25238571 SGTC_1129 3453-1384 223 µM 1.99664233801127 0.0115537876589736 no 84 0.022932025075066 270 1084452 SGTC_2717 st081029 62.2815 µM 1.9883209799615 0.0118425860678624 no 85 0.0233881009566713 172 5292846 SGTC_3342 9147791 14.508 µM 1.98685851531067 0.0118939838157942 no 86 0.0234690389733639 209 1838168 SGTC_443 clozapine 122 µM 1.9828803484672 0.0120347751741035 no 87 0.0236903981187032 146 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2094 5332512 191.667 µM 1.97362221127222 0.0123680363709191 no 88 0.0242123581148745 255 755774 SGTC_648 0375-0473 33.3 µM 1.96431946238863 0.0127109256442906 no 89 0.0247465280273407 251 1713139 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.95881035296616 0.0129178391503777 no 90 0.0250675003458611 214 4213774 SGTC_1034 k072-0165 12.7 µM 1.95750384149324 0.0129673348123708 no 91 0.0251441302907666 264 5835461 SGTC_916 4466-0038 42 nM 1.95406925028844 0.0130982331216434 no 92 0.0253465140185023 354 5722064 YGL116W CDC20 SGTC_1217 1183-1422 255 µM 1.95190144109694 0.0131814387201221 no 93 0.0254749535838296 236 2849664 SGTC_2555 cholic acid 100 µM 1.95071435606536 0.0132271950546115 no 94 0.0255455173229145 208 6708657 Influences liver metabolism. SGTC_2886 9058944 51.95 µM 1.94653540721245 0.0133893666484793 no 95 0.0257952295244224 94 4949929 SGTC_279 1273-0055 2.93 µM 1.94643435385205 0.0133933093733576 no 96 0.0258012931534541 256 2847562 SGTC_383 2324-0395 7.37 µM 1.92938340724183 0.0140730926533043 no 97 0.0268416410291396 256 3146421 SGTC_1306 1185-0270 9.02 µM 1.92635567804026 0.0141968601777668 no 98 0.0270299888184354 261 1548076 SGTC_1261 0712-0010 12.7 µM 1.92250652618358 0.0143555587717675 no 99 0.0272710266041429 276 2840123 SGTC_2348 9022543 33.42 µM 1.91097008744889 0.0148403827658189 no 100 0.0280042125272735 255 3162678 YDL140C RPO21 SGTC_988 1497-1057 103 µM 1.90590213990911 0.0150577773671496 no 101 0.0283314516888193 251 3533044 SGTC_1955 wogonin 32.4 µM 1.90453140235773 0.015117044644859 no 102 0.0284205054666737 224 5281703 A flavanone. SGTC_3353 9151644 39.2805 µM 1.90123035765763 0.0152605967710007 no 103 0.0286359232041891 241 4909158 SGTC_1451 4152-0210 104 µM 1.89868263171744 0.0153721885102547 no 104 0.0288031082543764 277 659563 SGTC_1322 1348-1070 12 µM 1.88416004850167 0.0160217549417127 no 105 0.0297716648849709 192 6758089 SGTC_1988 st071872 53.4 µM 1.87934233439662 0.0162423756758186 no 106 0.0300988823542117 221 16414116 SGTC_1382 3002-2117 298 µM 1.84094011735568 0.0180958088070974 no 107 0.0328151673045613 266 1497314 SGTC_2246 7293507 91.5585 µM 1.83797155325364 0.0182463062319628 no 108 0.033033298589181 280 887656 SGTC_846 0335-0850 148 µM 1.83740045763705 0.0182753810878693 no 109 0.0330753996619605 236 6819598 SGTC_3297 9117502 71.43 µM 1.83299560431084 0.018500964288072 no 110 0.0334016123922372 213 7453720 SGTC_1998 st075797 76.8 µM 1.80593903086825 0.0199392346871808 no 111 0.0354639317763088 307 24208315 SGTC_2107 5363541 170.161 µM 1.804179396096 0.0200359719046106 no 112 0.0356015941234059 277 244052 SGTC_2968 9090663 33.37 µM 1.80221020251574 0.0201447015410742 no 113 0.0357561700602585 310 25236811 SGTC_382 3229-0966 23.2 µM 1.79384651325042 0.0206120976444799 no 114 0.0364188352669796 291 5722370 SGTC_2932 9016711 44.54 µM 1.78971802567899 0.0208461798656363 no 115 0.0367496265459926 332 7117328 SGTC_2049 5262831 67.185 µM 1.78577707051025 0.0210717247587579 no 116 0.0370676803748479 292 763417 SGTC_4 0960-0234 25.671 µM 1.78130858113455 0.0213299554362604 no 117 0.0374310267056622 266 6821112 SGTC_2208 7283366 200 µM 1.76634507968627 0.0222142510198632 no 118 0.0386689864768774 277 898663 SGTC_2551 apiole 73.87 µM 1.76175545931331 0.0224916060071032 no 119 0.0390553115741555 171 10659 A possible DNA adduct former. SGTC_56 0957-0365 83.25 µM 1.75214153310715 0.0230820578744927 no 120 0.0398747370595757 330 6752360 SGTC_1525 8-methoxypsoralen 92.5 µM 1.74184505126209 0.0237288515003434 no 121 0.0407677805642365 349 4114 Related to psoralen; DNA damaging agent. SGTC_580 1123-0028 41 µM 1.73984768885181 0.0238560685491714 no 122 0.0409428830712092 374 1677248 YPR107C YTH1 SGTC_63 0099-0242 26.702 µM 1.73545373372471 0.0241379494725306 no 123 0.041330234797868 390 3898502 YLR359W ADE13 SGTC_2050 5263056 171 µM 1.73179998538624 0.0243744703424875 no 124 0.0416545903833056 372 763468 YGL055W OLE1 SGTC_910 3454-3003 490 µM 1.72341350709455 0.024924725127208 no 125 0.0424068870190622 350 820824 SGTC_2200 6600604 21.907 µM 1.71788084959697 0.025293407512801 no 126 0.0429091752652409 356 2904777 SGTC_1948 st076329 66.6 µM 1.7158680031301 0.0254286671723223 no 127 0.0430931021015108 300 24208413 SGTC_1969 st069479 40.1 µM 1.71420432608305 0.0255409200947622 no 128 0.0432456033355342 282 3895485 SGTC_2840 9008771 71.43 µM 1.71069400531082 0.0257791330072993 no 129 0.0435688074596509 249 2992978 SGTC_38 0929-0051 58.268 µM 1.70971128051096 0.0258461535986858 no 130 0.0436596378682343 352 1379719 SGTC_1924 st058459 75.1 µM 1.70858415483292 0.025923201596857 no 131 0.0437640028955019 271 688683 SGTC_39 0986-0283 58.349 µM 1.70849690050212 0.0259291741291087 no 132 0.0437720905057895 381 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_673 1082-0474 110 µM 1.70144502803339 0.0264156931988268 no 133 0.0444297260426029 423 3098046 SGTC_1703 st026983 48.3 µM 1.70098676930708 0.0264475713934893 no 134 0.044472735827504 320 1104023 SGTC_2623 humulene 100 µM 1.70084293118297 0.0264575839390682 no 135 0.0444862426419736 267 6187145 An anti-inflammatory. SGTC_699 0375-0592 111 µM 1.69905516835392 0.0265822943473787 no 136 0.0446543946926368 294 762578 SGTC_41 0478-0632 82.643 µM 1.69865065593744 0.0266105802710729 no 137 0.044692512947704 388 3750424 SGTC_2853 9015042 58.44 µM 1.69738721546545 0.0266990895273551 no 138 0.0448117389953395 291 6457456 SGTC_2696 st077691 74.316 µM 1.69483792465184 0.0268784266127476 no 139 0.0450530854655992 307 757133 SGTC_1284 0929-0043 16 µM 1.67901577352277 0.0280141059726077 no 140 0.0465744848366357 357 1239883 SGTC_2798 7813637 45.45 µM 1.67463004043792 0.0283358863402464 no 141 0.0470034207231474 353 956368 SGTC_3230 9131665 49.47 µM 1.67329973517498 0.0284340964431121 no 142 0.0471341522873668 159 15943720 SGTC_638 3970-0837 4.09 µM 1.6705515880995 0.028637876049258 no 143 0.0474051408174473 350 4118451 YLR208W SEC13 SGTC_133 0724-0033 378.92 µM 1.6635953164353 0.0291591287086849 no 144 0.048096664249029 312 280309 SGTC_619 1652-1634 108 µM 1.6609856704523 0.0293566989425428 no 145 0.0483581623384494 298 5400454 SGTC_1269 0831-0796 3.05 µM 1.66076480171957 0.0293734713016167 no 146 0.0483803464591893 335 927758 SGTC_1808 st050063 61.5 µM 1.65681100456421 0.02967506385439 no 147 0.0487788457247339 330 4011993 SGTC_2763 lisinopril 49.32 µM 1.65317207140237 0.0299549053363649 no 148 0.0491479243733243 282 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1921 5740136 50 µM 1.63770936337739 0.0311685362231969 no 149 0.0507411682163384 418 1774243 SGTC_2847 9005661 71.43 µM 1.63398405926401 0.0314669287779031 no 150 0.0511310988937572 218 2991449 SGTC_3096 9117468 49.47 µM 1.63329236428003 0.0315225918739803 no 151 0.0512037609757611 251 41316311 SGTC_1004 4084-0029 199 µM 1.62823190603836 0.0319323050765698 no 152 0.051737860921853 378 716894 YLR208W SEC13 SGTC_1642 st009582 77.7 µM 1.62810491932664 0.0319426426860101 no 153 0.0517513203215844 312 6739311 SGTC_2914 7968218 45.32 µM 1.6199038594295 0.0326161428585703 no 154 0.0526264653397458 295 2977111 SGTC_2918 7977171 22.06 µM 1.60951637302607 0.0334859676072233 no 155 0.0537517388927775 341 2236483 SGTC_753 1322-0200 289 µM 1.60606072300966 0.0337795351917418 no 156 0.05413028432738 367 5403907 SGTC_803 4488-1585 147 µM 1.60080105128842 0.0342304211618171 no 157 0.0547104953480258 326 747204 SGTC_2584 androsterone 48.74 µM 1.60009939909028 0.0342909426698513 no 158 0.0547882671462033 538 2754130 A steroid. SGTC_1455 4262-0120 131 µM 1.59964287776509 0.0343303674466274 no 159 0.0548389153143961 371 1529587 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.59858653467813 0.0344217351326563 no 160 0.0549562518198661 375 94937 An inhibitor of serotonin biosynthesis. SGTC_694 1315-0438 43.2 µM 1.59154668031804 0.0350357577320418 no 161 0.0557432993777144 308 6793154 SGTC_2299 7976368 114.88 µM 1.58872036271162 0.03528478742391 no 162 0.0560617698020967 351 2979718 SGTC_522 1273-0010 11.6 µM 1.57909887233305 0.0361434521246436 no 163 0.0571566901575102 364 5705015 SGTC_732 3970-1727 52.7 µM 1.57862139342812 0.0361865062400737 no 164 0.0572114623047211 346 1275699 SGTC_2995 9067767 71.4286 µM 1.57738641410389 0.0362980587053766 no 165 0.0573533197871506 330 11673567 SGTC_2292 7671323 168.05 µM 1.57266161878381 0.0367274385381365 no 166 0.0578985957598208 405 937504 SGTC_1203 3992-3522 103 µM 1.57058210293665 0.0369177328362034 no 167 0.058139874888775 418 5322312 SGTC_1186 1319-0216 26 µM 1.56820999389278 0.0371357854352342 no 168 0.0584160664153028 412 4565136 SGTC_2576 guaiol 23.12 µM 1.56577017574241 0.0373611589410568 no 169 0.0587012153585975 403 227829 SGTC_822 1487-0950 154 µM 1.56028887335511 0.0378715594640711 no 170 0.0593458157906329 372 1958375 SGTC_1191 1487-1166 10.6 µM 1.5515259206367 0.0386993439394066 no 171 0.0603878502521961 479 3955771 SGTC_2935 9038016 29.96 µM 1.54073799421165 0.039738596556281 no 172 0.0616902828954491 425 6463195 SGTC_12 0849-0099 9.267 µM 1.53266207660898 0.040531347860096 no 173 0.0626795688686895 385 6071388 SGTC_1328 1441-0025 69.2 µM 1.53185622827173 0.040611151401335 no 174 0.0627789585209026 353 4562601 SGTC_140 0062-0056 502.533 µM 1.52778723900107 0.0410160552102882 no 175 0.0632826858128622 456 3758964 SGTC_749 1000-0129 128 µM 1.51674595360282 0.0421312858248712 no 176 0.0646654186089501 459 708470 SGTC_3293 9120939 62.045 µM 1.51666494091299 0.0421395583464228 no 177 0.0646756500922776 398 934087 SGTC_2965 9082772 38.63 µM 1.51445144664708 0.0423660959562189 no 178 0.0649556897068713 442 16459634 SGTC_189 3970-0742 2.116 µM 1.51344425490355 0.0424695014888936 no 179 0.0650834254673901 372 2891807 SGTC_2239 6685329 187.64 µM 1.50825269769495 0.0430057460898391 no 180 0.0657449323045995 433 805680 SGTC_1061 3448-9325 110 µM 1.50723330890539 0.0431116802969606 no 181 0.0658754326065654 368 723482 SGTC_1246 0422-0085 105 µM 1.5071082082304 0.0431246951848182 no 182 0.0658914615881525 459 264295 SGTC_2441 5730946 39.09 µM 1.50679200642454 0.0431576054877039 no 183 0.0659319895760643 420 1774275 SGTC_2439 5492030 7.2 µM 1.50532708619287 0.043310339256371 no 184 0.066120002362276 397 5722370 SGTC_769 0302-0231 76 µM 1.50362766242864 0.0434880690848572 no 185 0.0663386321963357 521 571869 YER009W NTF2 SGTC_2260 7964312 200 µM 1.50163101132628 0.0436976353400886 no 186 0.0665962148930899 382 231951 SGTC_1223 0764-0573 147 µM 1.49498799405066 0.044400750645003 no 187 0.0674587877535227 472 1609797 SGTC_2608 thymoquinone 42.66 µM 1.49390308025054 0.0445164422079851 no 188 0.0676004766255159 369 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.49309464468005 0.0446028088702334 no 189 0.0677062070891559 368 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3336 9143619 71.43 µM 1.49094248809434 0.0448333857578657 no 190 0.067988297516455 449 45595730 SGTC_3354 9151612 71.43 µM 1.48811272961198 0.0451380187600197 no 191 0.0683605834768518 450 27261949 SGTC_2839 9003951 25.97 µM 1.48505556497515 0.0454690022734182 no 192 0.0687645527831679 389 2990634 SGTC_2099 5377090 177.372 µM 1.4845153432118 0.0455276917211582 no 193 0.0688361278859674 451 2243829 SGTC_391 gliotoxin 8.33 µM 1.4845103707453 0.0455282322104488 no 194 0.0688367869650484 461 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1811 st050069 61.5 µM 1.48048832418008 0.0459671069729034 no 195 0.0693714871909496 351 3877702 SGTC_2076 5212012 200 µM 1.47996962270493 0.0460239528775629 no 196 0.0694406768280507 325 604802 SGTC_1861 st057647 17.4 µM 1.47620749558123 0.0464379467034391 no 197 0.0699440989727273 434 688668 SGTC_3226 9131256 49.47 µM 1.47584777192009 0.0464776876720167 no 198 0.0699923814552458 273 17178073 SGTC_310 1273-0058 1.06 µM 1.47557607985793 0.0465077213193178 no 199 0.0700288652406682 690 2734232 SGTC_2946 9065502 71.43 µM 1.47495743543983 0.0465761662261735 no 200 0.070111993619383 269 16489101 SGTC_2184 6075246 200 µM 1.47348299225047 0.0467396200039382 no 201 0.0703104232739741 426 2267320 SGTC_2412 st077135 33.4 µM 1.47072000436539 0.047047158216648 no 202 0.0706834269845746 451 13258915 SGTC_367 0335-0881 7.1 µM 1.46700098133686 0.0474636686314428 no 203 0.0711878941963696 485 23828853 SGTC_323 4013-0906 34.3 µM 1.46521403552886 0.0476648449717342 no 204 0.0714312657238978 408 2910086 SGTC_2605 digitonin 300 nM 1.45690155714143 0.0486096661645747 no 205 0.0725717780809657 519 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2770 toltrazuril 17.5 µM 1.45064687818314 0.0493304163765526 no 206 0.0734391073112774 461 68591 Kills coccidiodes. SGTC_480 am 92016 50 µM 1.44736269212109 0.0497122676368514 no 207 0.073897684511611 391 2129 K+ channel blocker. SGTC_2272 7805186 180 µM 1.44652177932076 0.0498104185629591 no 208 0.0740154539205617 421 2956062 YPR165W RHO1 SGTC_27 0485-0001 32.618 µM 1.4414816180417 0.0504019476749609 no 209 0.0747243333981955 326 2054479 SGTC_2523 spermine 47.74 µM 1.44070310311396 0.0504938136776291 no 210 0.0748342889340117 429 1103 A DNA binding polyamine. SGTC_2909 7941780 10.49 µM 1.43973173696196 0.0506086234381397 no 211 0.0749716553445733 456 1243215 SGTC_1711 st032263 62.8 µM 1.43808152905647 0.0508041448822523 no 212 0.0752054614122871 439 3958979 SGTC_2871 9038510 12.99 µM 1.4375679657794 0.0508651159239966 no 213 0.0752783378027918 463 4945164 SGTC_2920 7982904 15.77 µM 1.43577175472009 0.051078823247419 no 214 0.0755336497766897 398 6456808 SGTC_2585 alliin 100 µM 1.43523951372174 0.0511422845964908 no 215 0.0756094286590927 493 87310 A garlic compound which reacts with lipids. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.43499268368176 0.0511717364753313 no 216 0.0756445912360924 499 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1080 nisoldipine 24.4 µM 1.43281814369674 0.0514317871742283 no 217 0.0759549074204369 495 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_324 1315-0088 19.6 µM 1.42938877581177 0.0518440359462166 no 218 0.076446261327854 396 6787421 SGTC_2863 9028737 58.44 µM 1.42912389178578 0.0518759869395928 no 219 0.0764843138256932 386 6460917 SGTC_2806 7952793 58.44 µM 1.42460572431651 0.0524233933973325 no 220 0.0771356022037582 468 2972490 SGTC_2859 9028643 45.46 µM 1.42439063170393 0.0524495672347356 no 221 0.0771667123070394 416 17151580 SGTC_919 tnp00227 403.569 nM 1.42183464056613 0.0527613912209659 no 222 0.0775371303844155 516 1269246 A methoxyflavone. YNL221C POP1 SGTC_1125 tnp00248 1.32998 µM 1.41853348652497 0.0531662975636335 no 223 0.0780175346345 587 24207736 SGTC_1184 1269-1718 139 µM 1.41301711562959 0.0538484073543693 no 224 0.0788253458324593 478 5403821 SGTC_3322 9139058 2.11 µM 1.40880579755609 0.0543737945741601 no 225 0.0794463001950023 471 4908926 YPR165W RHO1 SGTC_1492 4158-0558 28.5 µM 1.4060403727398 0.0547209979878242 no 226 0.0798560683203571 449 3967268 SGTC_1804 st050076 49.1 µM 1.40520360021235 0.0548264007977235 no 227 0.0799803719468129 484 3895976 SGTC_2213 7173844 200 µM 1.40168548058669 0.0552713122592823 no 228 0.0805045941291117 474 892728 SGTC_1346 1488-2224 62.4 µM 1.40118268372554 0.0553351296150181 no 229 0.0805797255581888 487 3722427 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.40025522382428 0.0554529998616591 no 230 0.080718452044183 566 551469 SGTC_466 geldanamycin 89.2 µM 1.39950704445124 0.0555482298519916 no 231 0.0808304936908108 342 5288382 HSP90 inhibitor. SGTC_2944 9067346 25.62 µM 1.39898533176782 0.0556147110039428 no 232 0.0809086908681619 491 6473075 SGTC_223 busulfan 5 mM 1.39744855074125 0.0558109059583296 no 233 0.0811393639593844 381 2478 A DNA alkylator. SGTC_1561 5-methoxyflavone 52.9 µM 1.39430831842343 0.0562135051809599 no 234 0.0816122600189703 394 94525 SGTC_1194 1488-0194 225 µM 1.3861753486425 0.057266855344647 no 235 0.0828466834495789 533 1391452 SGTC_632 0781-2353 4.65 µM 1.38549231677893 0.0573560212845676 no 236 0.0829509901174397 522 6811515 YHR007C ERG11 SGTC_294 k038-0071 157 µM 1.38440137317323 0.0574986643239244 no 237 0.0831177943600054 503 24152826 SGTC_2471 5466956 24.79 µM 1.3812846371744 0.0579077214681901 no 238 0.0835957299748946 451 724419 SGTC_862 0452-0056 10.2 µM 1.38093077302262 0.0579543087363591 no 239 0.083650123510305 470 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2371 9071574 200 µM 1.37968644107514 0.0581183626954957 no 240 0.0838416047189012 418 45596039 SGTC_2843 9000894 45.46 µM 1.37937464068774 0.0581595278878534 no 241 0.0838896369570193 345 2242070 SGTC_2640 pentamidine 10.38 µM 1.37684813987352 0.0584939325126223 no 242 0.0842796018632084 553 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1799 st045822 46.1415 µM 1.3763248501609 0.0585633828852649 no 243 0.0843605413292438 467 3674992 SGTC_2644 guaiazulene 100 µM 1.36640261359165 0.0598925391856752 no 244 0.0859063144596034 462 3515 A coloring agent. SGTC_2667 digitoxin 100 µM 1.3635708443762 0.0602761776755257 no 245 0.0863513367313703 389 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_658 3253-0951 102 µM 1.36310489857383 0.0603394863091576 no 246 0.086424726587198 620 1184878 SGTC_193 1273-0060 1.558 µM 1.36285612309532 0.0603733090452939 no 247 0.08646392962856 404 2847393 YHR072W ERG7 SGTC_1828 st055811 49 µM 1.36141490910544 0.0605695440323248 no 248 0.0866913035844131 432 5877589 SGTC_640 3381-0960 37.1 µM 1.35998435659349 0.0607648204714595 no 249 0.0869174371481313 522 1745025 SGTC_2361 9034121 116 µM 1.35641133175522 0.0612547040416686 no 250 0.0874841649004746 492 6496917 SGTC_2915 7971052 15.16 µM 1.35215143203826 0.0618427890097163 no 251 0.088163438482294 353 5741558 SGTC_2736 butenafine 14.65 µM 1.35188677678265 0.0618794699286992 no 252 0.0882057691444333 557 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_142 0335-0849 62.6745 µM 1.34354661579319 0.0630441286247305 no 253 0.0895475211214018 650 3889043 YPR107C YTH1 SGTC_859 0439-0102 54.6 µM 1.3417871345099 0.0632919978702218 no 254 0.0898325124405618 562 610143 SGTC_1906 st060206 94.7 µM 1.34103887185698 0.0633976400240341 no 255 0.0899539161118581 540 5133468 SGTC_222 nsc-310342 10.666 µM 1.34089618484387 0.0634178006135923 no 256 0.0899770805444283 376 432556 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.33797748344847 0.0638312868769434 no 257 0.0904518884443724 500 803109 SGTC_794 k038-0031 316 µM 1.33391245892197 0.0644106605436615 no 258 0.0911162739618697 615 6624242 SGTC_2861 9024595 19.48 µM 1.33307783609182 0.0645301204492847 no 259 0.0912531309854747 386 16482810 SGTC_1946 st076057 65.1 µM 1.33207767525719 0.0646735005001143 no 260 0.0914173327367302 385 953009 SGTC_1935 st074532 41.6 µM 1.33178148870371 0.0647160083642121 no 261 0.091466001273935 614 2829742 SGTC_1685 st024049 53.0905 µM 1.32865910674998 0.0651654448727086 no 262 0.0919802310472518 480 1941139 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.32580616243219 0.0655782124691075 no 263 0.0924519556402375 606 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_73 0327-0325 16.231 µM 1.32336818190273 0.0659325465280393 no 264 0.0928564838156784 615 53298 SGTC_608 k048-0125 159 µM 1.32226825180258 0.0660928943270657 no 265 0.0930394203706588 544 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2469 5655019 90.81 µM 1.31920964529715 0.0665403661162087 no 266 0.093549517303816 556 2788239 SGTC_1276 0871-0068 94.2 µM 1.31897602376664 0.066574640937255 no 267 0.0935885641039605 495 3414906 SGTC_1912 st060209 90.8 µM 1.31895385387824 0.0665778942109709 no 268 0.093592270137588 509 688787 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.31185128577421 0.0676264943761432 no 269 0.0947851583846963 595 688761 SGTC_713 1488-1073 324 µM 1.31112670486611 0.0677341824423202 no 270 0.0949074799330837 517 3312542 SGTC_1305 1181-0477 144 µM 1.31044010976317 0.0678363471967083 no 271 0.095023496112501 518 6252086 SGTC_2121 5257820 149.641 µM 1.30454708473868 0.0687181248572405 no 272 0.0960235583068223 582 791256 SGTC_2625 euphol 100 µM 1.30203530779445 0.0690966396302218 no 273 0.0964521580170107 589 6708538 A triterpene alcohol. SGTC_3212 9128307 49.47 µM 1.29880641747344 0.069585578312003 no 274 0.0970051858661401 476 27243542 SGTC_1081 sertraline 6 µM 1.29792790579452 0.0697190679392891 no 275 0.097156054886769 600 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_187 1488-2104 32.728 µM 1.2967868524517 0.0698927448918714 no 276 0.0973522678308733 566 2852859 SGTC_1814 st052110 31.539 µM 1.29651941888038 0.0699334984252208 no 277 0.0973982971237592 503 674163 SGTC_411 enrofloxacin 100 µM 1.29060773090345 0.0708390426695852 no 278 0.0984198669509355 535 71188 A bacterial gyrase inhibitor. SGTC_745 0469-0705 296 µM 1.28583987424188 0.0715759170656716 no 279 0.0992494754937957 631 3486736 SGTC_635 k038-0028 24.7 µM 1.28115642055094 0.0723054589523524 no 280 0.100069364847105 569 4035102 SGTC_352 k048-0007 5.11 µM 1.27851802707137 0.0727189433906294 no 281 0.100533416316995 627 6811911 SGTC_683 panaxydol 45 µM 1.27396172694279 0.0734372588136721 no 282 0.101338490234922 599 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2622 2-methoxyxanthone 59.94 µM 1.27374433414541 0.0734716666403148 no 283 0.101377019440483 600 71034 A hepatoprotective. SGTC_959 1222-0044 107 µM 1.26823616954855 0.0743475902776046 no 284 0.102356812001935 569 6083612 SGTC_2742 clothiapine 36.27 µM 1.26458149192897 0.0749331530601544 no 285 0.103010695570081 518 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2248 tofa 1.1 µM 1.262623206552 0.0752483592186953 no 286 0.103362311923206 537 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2910 7948405 25.97 µM 1.26193571219524 0.075359257907583 no 287 0.103485960116556 515 2971328 SGTC_1691 st019933 84.6 µM 1.26156267202586 0.0754194845755363 no 288 0.103553097570207 546 6176082 SGTC_2400 5203494 178.7 µM 1.25676646634285 0.0761970946846978 no 289 0.104419106069925 537 6777674 SGTC_1919 st067113 52.3 µM 1.25596498817609 0.0763276315013331 no 290 0.104564332163369 597 1268243 SGTC_1977 st070720 65.3 µM 1.25487197904157 0.0765059241727704 no 291 0.104762618782713 522 682188 SGTC_2670 beta-carotene 100 µM 1.25422658679398 0.0766113498218123 no 292 0.104879829438521 483 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1088 bifonazole 369 nM 1.25043436870588 0.077233046718422 no 293 0.105570458157057 571 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1351 1496-0003 46.5 µM 1.24972433499736 0.0773498745954837 no 294 0.105700132302646 601 3891978 SGTC_631 k072-0230 41.5 µM 1.24746469724498 0.07772256540218 no 295 0.106113578440035 629 5773147 SGTC_1361 1608-0041 5.61 µM 1.24625665462777 0.0779223709179565 no 296 0.106335092792694 592 X1361 SGTC_1137 ixabepilone 100 µM 1.24485105304589 0.0781553422346417 no 297 0.106593252902497 641 154225 A novel microtubule stabilizer. SGTC_654 1124-0271 80.9 µM 1.24480396666698 0.0781631556985083 no 298 0.106601908857002 611 5403748 SGTC_1739 st037196 92.5 µM 1.24374739916717 0.0783386372417462 no 299 0.106796272573249 621 612214 SGTC_2358 9037157 4 µM 1.24189961598947 0.0786462468206515 no 300 0.107136800904173 592 2388925 SGTC_718 1130-0073 349 µM 1.24040398895206 0.0788959008828076 no 301 0.107413003168666 619 6740020 SGTC_1385 3091-4834 14.1 µM 1.23914907596677 0.0791058371215536 no 302 0.10764514768467 543 4072814 SGTC_1330 1469-0054 61.8 µM 1.23170963755644 0.0803590877866994 no 303 0.109028784209547 592 7102664 SGTC_1156 4092-0367 4.88 µM 1.23115133433223 0.0804537415505252 no 304 0.109133134475272 609 1357585 SGTC_2174 5790901 200 µM 1.23035061106627 0.0805896417891386 no 305 0.10928291977054 584 786020 SGTC_669 0108-0021 26.2 µM 1.22235316323977 0.0819565115396569 no 306 0.110787051493276 715 17201 SGTC_2008 4012253 172 µM 1.22191484948134 0.0820319270509303 no 307 0.110869914664117 620 603940 SGTC_2753 fluvastatin 17.09 µM 1.21710107562894 0.0828636200573608 no 308 0.111782880757208 622 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2252 omeprazole 400 µM 1.21701830188811 0.0828779764496704 no 309 0.111798626266421 495 4594 A proton pump inhibitor. SGTC_1793 st048256 72.231 µM 1.21618903332104 0.0830219092363315 no 310 0.111956460180952 591 672022 SGTC_2034 5197015 53.07 µM 1.21323684859801 0.0835358341491807 no 311 0.112519639810086 617 780676 SGTC_2262 9014885 67.46 µM 1.2119287242627 0.0837643190984365 no 312 0.11276983279968 505 6457424 SGTC_595 3909-8003 73.7 µM 1.21122658582773 0.083887152314401 no 313 0.112904288106794 611 699517 SGTC_967 1306-0166 352 µM 1.2098239747913 0.0841329322662526 no 314 0.113173222264415 613 4437607 SGTC_2955 9076254 12.21 µM 1.2059319684905 0.0848177604868616 no 315 0.113921861511571 571 16459619 SGTC_2384 9036245 200 µM 1.20404369078003 0.0851515194027767 no 316 0.114286346048356 628 6462766 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.20182732183813 0.0855445238418446 no 317 0.114715218760308 700 6708739 YPR165W RHO1 SGTC_1315 1237-0019 3.69 µM 1.20112209053366 0.0856698592157884 no 318 0.114851922565802 641 825140 SGTC_2888 9058547 12.99 µM 1.19959970364729 0.0859408900638935 no 319 0.115147420861672 520 16476514 SGTC_410 α-linolenic acid 100 µM 1.19652721145952 0.0864898399317985 no 320 0.115745443083007 658 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2158 5657123 3.6195 µM 1.19381878796783 0.0869759133560412 no 321 0.116274430346682 622 2858827 SGTC_938 3126-1755 342 µM 1.19340902692963 0.0870496294242436 no 322 0.116354610702574 660 1777771 SGTC_1776 st049249 45.9 µM 1.19128577870846 0.0874323495767901 no 323 0.116770707432202 640 1822314 SGTC_3311 9131146 2.8755 µM 1.18999154998486 0.0876662524371091 no 324 0.117024856632649 643 4900406 YPR165W RHO1 SGTC_1282 0886-0010 32.4 µM 1.18965370469838 0.0877273871796603 no 325 0.117091264171362 711 2836211 YNL267W PIK1 SGTC_322 k048-0136 19.3 µM 1.18718678142952 0.0881747532126831 no 326 0.117576976847312 601 6823282 SGTC_1500 4488-1866 171 µM 1.18629398975549 0.0883370755794815 no 327 0.117753109668253 677 2900003 SGTC_2398 5228213 48.84 µM 1.18448549634645 0.0886665679421676 no 328 0.118110467106151 726 80771 YMR134W ERG29 SGTC_2150 5556613 200 µM 1.18156199604859 0.0892011397187203 no 329 0.118689770262444 665 743190 SGTC_2941 9056145 11.23 µM 1.18119731776015 0.0892679902370912 no 330 0.118762173287822 540 2119517 SGTC_295 k015-0027 31 µM 1.18094114946811 0.089314971672672 no 331 0.118813051451129 635 3887424 SGTC_3086 9117350 49.47 µM 1.18069966548004 0.0893592768385234 no 332 0.118861027227246 550 2679265 SGTC_1602 st001878 87.6 µM 1.18045319135858 0.0894045144036253 no 333 0.118910008504105 624 595405 YLR310C CDC25 SGTC_154 3389-1638 511.116 µM 1.18025554202172 0.0894408030318787 no 334 0.118949297233212 558 5238686 SGTC_1435 4092-0789 56.7 µM 1.17392350118703 0.0906091775359291 no 335 0.120212834106517 656 2248285 SGTC_2032 5185112 25.99 µM 1.17001670646544 0.0913356802499559 no 336 0.120997122886774 594 5718189 SGTC_539 4859-0462 2.54 µM 1.16970923965134 0.0913930391788005 no 337 0.121058999292546 647 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1201 1889-3372 45.9 µM 1.1655575517432 0.0921701662892497 no 338 0.121896689297685 622 5392199 SGTC_628 1636-0253 16 µM 1.16078458370363 0.0930696187855114 no 339 0.122864756933299 690 4456143 SGTC_1997 st073024 93.8 µM 1.15895161202248 0.0934167558212857 no 340 0.123237954635216 646 686268 SGTC_987 1497-1013 404 µM 1.1581929744951 0.0935607097641932 no 341 0.123392647354489 616 1676435 SGTC_1509 1326-1131 80 µM 1.15528542573589 0.0941139437688442 no 342 0.12398678109817 624 768313 SGTC_2820 7989630 71.43 µM 1.15433170754462 0.0942959371923925 no 343 0.12418210091423 534 2984098 SGTC_2466 5983409 37.09 µM 1.15139219775355 0.0948585023518324 no 344 0.124785461107024 633 2879657 SGTC_416 estradiol valerate 100 µM 1.15115608434808 0.0949037969453862 no 345 0.12483401418617 644 13791 A steroid. SGTC_1030 k029-0042 36.7 µM 1.15070377365526 0.0949906100394364 no 346 0.124927061762521 712 6080581 SGTC_257 daunorubicin 18.5 µM 1.15009231383882 0.0951080619883187 no 347 0.125052925878724 643 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2828 7998861 71.43 µM 1.14814399554983 0.0954830170412604 no 348 0.12545456224362 570 2988188 SGTC_511 blebbistatin 171 µM 1.14351717462636 0.0963778092294732 no 349 0.126411964052864 652 3476986 A myosin inhibitor. SGTC_80 0159-0065 512.242 µM 1.14200182634513 0.0966722015477488 no 350 0.126726630266641 559 1548079 SGTC_1590 st077108 57.8 µM 1.14091045540424 0.0968846349951735 no 351 0.126953594024998 659 5489485 SGTC_1420 4'-methoxyflavone 42 µM 1.13828224835197 0.0973976170479669 no 352 0.12750132201421 682 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.13743623225123 0.0975631684023121 no 353 0.127677983968069 615 17037758 SGTC_1317 1273-0028 910 nM 1.13506625646574 0.0980280320421989 no 354 0.128173779251618 678 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3236 9132701 49.47 µM 1.13501663508904 0.0980377824431795 no 355 0.128184174238378 660 24282524 SGTC_2550 chrysin dimethyl ether 71.87 µM 1.13265551465044 0.0985025548527039 no 356 0.12867947291032 524 88881 An O-methylated flavonoid and antioxidant. SGTC_532 1548-0774 215 µM 1.12821909380445 0.0993801971377664 no 357 0.129613701041182 706 5932993 SGTC_831 k061-1017 217 µM 1.1257937032092 0.099862414168898 no 358 0.130126425037995 838 1240153 SGTC_161 4065-0411 162.148 µM 1.12306850787764 0.100406274922568 no 359 0.13070419989895 732 1906281 YLR208W SEC13 SGTC_1996 st072960 66.8 µM 1.12234471554057 0.100551083020472 no 360 0.130857950363553 725 1719405 SGTC_255 tunicamycin 200.472 nM 1.11841569267069 0.101339815914364 no 361 0.131694747582971 684 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2567 aureobasidin a 60 nM 1.11828513935024 0.101366101034589 no 362 0.131722615869804 691 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3060 1327-0027 12.5 µM 1.1176035727584 0.101503405767953 no 363 0.131868171105303 656 16000455 YPR107C YTH1 SGTC_551 k048-0028 34.9 µM 1.1175214767638 0.10151995352095 no 364 0.131885710994978 746 6836383 SGTC_881 0833-0569 170 µM 1.11481111615373 0.102067373457005 no 365 0.132465685944907 693 5418700 SGTC_2545 solidagenone 89.61 µM 1.1137864958021 0.102274877648184 no 366 0.132685395835537 454 6708572 An anti ulcer agent SGTC_2432 5630864 12.22 µM 1.11350378234393 0.102332186220519 no 367 0.132746062392439 672 5714970 SGTC_1188 1403-0014 4.57 µM 1.11098971811612 0.102842837252782 no 368 0.133286387521602 757 9614867 SGTC_3048 9093155 49.47 µM 1.10997018739685 0.10305044884496 no 369 0.133505936717701 621 25236002 SGTC_1274 0865-0114 173 µM 1.10991489584962 0.103061716805636 no 370 0.133517850492632 697 870624 SGTC_1045 1348-1485 165 µM 1.10954388241535 0.103137349429289 no 371 0.13359781237754 756 6810614 SGTC_2595 hexamethylquercetagetin 100 µM 1.10001229407325 0.105094242700268 no 372 0.135663382673871 661 386331 SGTC_2866 9034245 58.44 µM 1.0994829472983 0.105203703139475 no 373 0.135778734036891 685 6462273 SGTC_464 bw-b 70c 158 µM 1.09764828235066 0.105583720899284 no 374 0.136179050521082 751 5353454 SGTC_865 0488-0499 301 µM 1.09586343042872 0.105954372401044 no 375 0.136569272410023 761 9634651 SGTC_1231 0242-0792 125 µM 1.09569466348971 0.105989468006494 no 376 0.13660620943043 703 3707635 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.09561332659642 0.106006385263774 no 377 0.136624013593924 760 4174840 SGTC_2594 a-mangostin 100 µM 1.09546258851913 0.106037742429053 no 378 0.136657013459959 735 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_895 0964-0006 13.7 µM 1.09397268050454 0.106348039877063 no 379 0.136983480109242 712 6738897 SGTC_685 1278-0033 54.9 µM 1.09213676463882 0.106731300211807 no 380 0.137386495973364 731 3590572 SGTC_1641 st009299 47.1 µM 1.09213131196834 0.106732439977729 no 381 0.137387694135193 635 4046054 SGTC_1832 st054113 55 µM 1.09068915513917 0.107034200943373 no 382 0.137704842091596 686 1251267 SGTC_3150 9097574 49.47 µM 1.08896679261018 0.107395398667954 no 383 0.138084264900625 698 17217476 SGTC_1494 4358-1428 177 µM 1.08767336944967 0.107667220303134 no 384 0.138369664064622 752 1564571 SGTC_3341 9147222 25.867 µM 1.08724768807477 0.10775678844625 no 385 0.138463680290918 665 1939759 SGTC_1889 st059080 5.18 µM 1.08523109398289 0.108181831952225 no 386 0.138909657907703 775 176925 Isolated from Daphnopsis sellowiana. SGTC_941 3237-0776 460 µM 1.08459815204224 0.108315487504471 no 387 0.139049836924496 678 760008 SGTC_2396 5342950 42.78 µM 1.08279638254236 0.108696609728885 no 388 0.139449405787491 748 1886677 SGTC_2311 7694451 200 µM 1.07888722826957 0.109526813895192 no 389 0.14031900149603 715 2163142 SGTC_428 3448-4153 16.5 µM 1.07743970662753 0.109835382702198 no 390 0.140641936607696 638 3834874 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.07740884350315 0.109841968594114 no 391 0.140648827509883 773 676296 Flavone; oxidizing agent. SGTC_2582 agaric acid 100 µM 1.07606413550452 0.11012919150739 no 392 0.14094928699259 914 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1252 0493-0875 34.8 µM 1.07505371048387 0.110345367480626 no 393 0.141175341083037 694 3960963 SGTC_319 1348-1596 45.5 µM 1.07318466358304 0.11074604347239 no 394 0.141594135176917 769 5380505 SGTC_1483 3453-0561 55.9 µM 1.07228134637705 0.110940064894597 no 395 0.141796841286463 759 4546991 SGTC_186 3455-3465 67.277 µM 1.07011729571491 0.111405866430273 no 396 0.142283257446519 649 755278 SGTC_571 k831-0106 44.2 µM 1.06990890798784 0.111450794666726 no 397 0.142330156517412 697 4783639 SGTC_3213 9129884 49.47 µM 1.06859693923529 0.111733951964419 no 398 0.142625664166667 641 17190742 SGTC_2641 levomentholum 100 µM 1.06659277481604 0.112167496120445 no 399 0.143077882275533 701 16666 SGTC_1719 st032227 49.2 µM 1.06521662124738 0.11246588336054 no 400 0.14338895685298 717 3125804 SGTC_2433 5607874 27.82 µM 1.06416590975497 0.112694087427702 no 401 0.143626773634822 725 2252428 SGTC_1248 0469-0687 58.6 µM 1.06411390638498 0.112705390623077 no 402 0.143638550925035 752 4017482 SGTC_1817 st052116 64.4 µM 1.05719374020534 0.114216752482912 no 403 0.145211588063081 733 4361398 SGTC_3168 9103419 49.47 µM 1.0516996822915 0.11542688967094 no 404 0.146468678411122 671 16649256 SGTC_2440 5628896 157.78 µM 1.04635419963052 0.116613019538207 no 405 0.14769876512596 742 5522048 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.04550630490633 0.116801953585704 no 406 0.14789451406314 747 2724278 An inhibitor of dopamine biosynthesis. SGTC_1663 st014140 55.4 µM 1.04267090251688 0.117435334303818 no 407 0.148550369328932 861 4207120 SGTC_1672 st016598 6.51 µM 1.0420015446054 0.117585211663761 no 408 0.148705481413022 741 4665860 YNL267W PIK1 SGTC_2685 mycophenolic acid 18.85 µM 1.04050789668698 0.117920145641371 no 409 0.14905199861148 750 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2316 5844804 197.44 µM 1.03896828287315 0.118266092818096 no 410 0.149409743711202 900 776813 SGTC_1097 itavastatin 7.23 µM 1.03656067891645 0.118808512490547 no 411 0.149970323311812 785 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3064 1327-0027 10 µM 1.03357325045886 0.11948400328198 no 412 0.150667854991338 604 16000455 YPR107C YTH1 SGTC_2282 7944268 200 µM 1.02964779736522 0.120375704675571 no 413 0.151587684588977 793 2970414 SGTC_377 3970-0964 33.1 µM 1.02815303544533 0.120716482280888 no 414 0.151938923152603 864 16481235 SGTC_1421 4029-0249 71.4 µM 1.0264281525029 0.121110566452246 no 415 0.152344906831536 872 2894095 SGTC_1984 st072354 53.1 µM 1.02615860302596 0.121172232115584 no 416 0.152408415371201 769 5762938 SGTC_2257 7960413 200 µM 1.0259589526197 0.12121792098779 no 417 0.152455466319806 832 2974689 YIL048W NEO1 SGTC_900 1112-0045 141 µM 1.0237110943862 0.121733166961117 no 418 0.152985876806684 644 56211 YIL048W NEO1 SGTC_3287 9117173 37.0625 µM 1.02228616660886 0.122060579636561 no 419 0.153322739288276 742 2789709 SGTC_784 4579-0127 173 µM 1.0194740567974 0.122708545264001 no 420 0.15398898176447 840 1948547 SGTC_2768 sulfasalazine 50.2 µM 1.01707579075726 0.123263056262735 no 421 0.154558687991837 781 5384001 An antioxidant and salicylic acid derivative. SGTC_1630 st005209 31.3 µM 1.01580717190212 0.123557086822433 no 422 0.154860610050019 864 3367314 SGTC_1498 4478-3555 97.6 µM 1.01552297097145 0.123623023984144 no 423 0.154928301182486 749 3437919 SGTC_2624 nerol 100 µM 1.01135197419383 0.124593567894053 no 424 0.155923999236118 781 637566 A natural product oil. SGTC_1022 4477-0945 21.3 µM 1.01087243921589 0.12470549072145 no 425 0.156038743327696 778 4648966 SGTC_1540 guanosine 70.6 µM 1.006429290639 0.12574585798289 no 426 0.157104554807076 755 6802 Guanosine is a purine nucleoside SGTC_712 r015-0009 80.6 µM 1.00575259888256 0.125904835700051 no 427 0.157267297085184 751 6813872 YLR060W FRS1 SGTC_84 0443-0269 128.823 µM 1.00393852581055 0.126331714016892 no 428 0.157704122705885 820 6150058 SGTC_3027 9089541 49.47 µM 1.00294674641357 0.126565520375999 no 429 0.157943278119213 780 9943819 SGTC_968 1309-0633 340 µM 1.00051923384238 0.127139063849821 no 430 0.158529647160533 794 3761976 SGTC_1331 1472-0049 76.2 µM 0.999999184548192 0.127262169690286 no 431 0.158655451247002 756 24051409 SGTC_848 0368-0089 85.6 µM 0.999530532823528 0.127373179734454 no 432 0.15876887790939 825 762535 SGTC_3125 9127534 49.47 µM 0.999269984018173 0.127434925335328 no 433 0.158831960903407 684 1639235 SGTC_110 0850-0284 111.64 µM 0.997541579722502 0.127845054582492 no 434 0.159250850881432 673 3906265 SGTC_1048 3161-0300 24.5 µM 0.997449074602233 0.127867030748932 no 435 0.15927329047571 823 2165101 SGTC_1744 st037937 38.9 µM 0.996117626099536 0.128183629834452 no 436 0.159596498343869 791 1016152 SGTC_985 1493-0307 8.71 µM 0.99567938996586 0.128287954996513 no 437 0.159702973579696 765 3278274 SGTC_3045 9092950 49.47 µM 0.994676250645604 0.128526981185523 no 438 0.159946874407986 845 44120432 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.993421737061431 0.128826339127337 no 439 0.160252236408282 746 77254 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.993375173654876 0.128837459608346 no 440 0.160263577767899 757 6708760 SGTC_1403 3909-7815 62.9 µM 0.993344781877885 0.128844718267589 no 441 0.160270980517673 769 6615483 SGTC_1815 st051655 58.2 µM 0.993009260357176 0.128924871835488 no 442 0.160352720827509 801 5984156 SGTC_644 1498-1197 63.3 µM 0.99033381143754 0.129565253849557 no 443 0.161005492696559 841 6741615 SGTC_565 1418-0001 44.5 µM 0.990274480414314 0.129579479955746 no 444 0.161019988260138 865 2862145 SGTC_1043 0916-0009 19.3 µM 0.98898393146726 0.129889189316197 no 445 0.161335501747404 930 3101130 SGTC_1514 1189-1591 158 µM 0.987853006597567 0.130161012683587 no 446 0.161612321609225 830 767698 YMR146C TIF34 SGTC_2025 5147754 141 µM 0.981467308380097 0.131703231862523 no 447 0.163181174074815 822 315777 YLR208W SEC13 SGTC_477 mead ethanolamide 10 µM 0.979699514252307 0.132132393865926 no 448 0.163617232981533 686 16061185 SGTC_2919 7978188 46.38 µM 0.97841611528732 0.132444564204426 no 449 0.163934280492804 839 2980291 SGTC_62 0180-0423 3.232 µM 0.978361230518562 0.132457925542981 no 450 0.163947847964531 812 30102 YGL099W LSG1 SGTC_1224 0823-0416 294 µM 0.977577621615917 0.132648791314856 no 451 0.164141634924997 837 3598164 SGTC_1350 1495-0454 146 µM 0.977210105277354 0.132738373510237 no 452 0.164232573098243 871 1069057 SGTC_2324 6149169 200 µM 0.9766847730525 0.132866495697752 no 453 0.164362617921918 790 2888231 SGTC_1059 3448-6867 171 µM 0.976151612201135 0.132996614232192 no 454 0.164494668944994 849 3934407 SGTC_1005 4092-0690 4.4 µM 0.97603512329756 0.133025055159263 no 455 0.164523529574217 767 1529343 SGTC_1636 st007707 68.9 µM 0.975165595741294 0.133237483776891 no 456 0.164739062451327 851 403051 SGTC_1250 0485-0349 40.2 µM 0.975045846170829 0.133266757291595 no 457 0.164768759525629 787 6842794 YDL195W SEC31 SGTC_371 0195-0006 7.36 µM 0.974821239835719 0.133321675617247 no 458 0.16482446971193 738 3928593 SGTC_2518 prenyletin 46.28 µM 0.974432544674105 0.133416751961708 no 459 0.164920908459547 729 3873459 A coumarin with calcium channel inhibitory activity. SGTC_858 0438-0351 2.77 µM 0.973059764700317 0.133752912447346 no 460 0.16526179981357 873 2799119 SGTC_2689 tacrolimus 100 µM 0.971414912454811 0.134156463038052 no 461 0.165670852750643 794 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1141 3253-0389 52.6 µM 0.967612074915075 0.135092656738545 no 462 0.166619072246754 834 5402031 SGTC_425 3825-7017 13.1 µM 0.967151321469348 0.135206389918285 no 463 0.166734196368548 863 3397440 SGTC_742 0kpi-0133 140 µM 0.966277210105747 0.135422337447165 no 464 0.166952743351139 868 2728852 SGTC_1750 st081859 2.357 µM 0.963438995363884 0.136125142111378 no 465 0.167663632412572 978 5291695 SGTC_542 3381-0244 89.3 µM 0.962795266645101 0.136284890249091 no 466 0.167825138293232 919 1112843 SGTC_2491 paeonol 100 µM 0.958045179363142 0.137467640173521 no 467 0.169019988568052 818 11092 Increases levels of cortical cytochrome oxidase. SGTC_2207 7258803 200 µM 0.95771407526908 0.137550344047117 no 468 0.169103478628291 792 3666799 SGTC_360 0957-0399 1.01 µM 0.954158159369084 0.138440689343272 no 469 0.170001795111474 875 6752301 YPR165W RHO1 SGTC_1510 1123-0200 71.5 µM 0.952125606428779 0.138951368860217 no 470 0.170516642031879 911 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3271 9137798 49.47 µM 0.951745902059001 0.139046911692164 no 471 0.170612931948159 781 6498326 SGTC_3302 9125395 16.351 µM 0.948432635895775 0.139882507426658 no 472 0.171454625799272 832 17599668 SGTC_3337 9144342 33.5465 µM 0.947600250911563 0.140092967716829 no 473 0.171666499200144 874 17682949 SGTC_1285 0929-0069 65.5 µM 0.945344635165342 0.140664358710682 no 474 0.172241478865081 853 1206237 SGTC_2175 5807670 165.306 µM 0.944139821826476 0.140970208330034 no 475 0.172549101078274 851 241186 SGTC_1271 0832-2808 169 µM 0.943437755031767 0.141148640358712 no 476 0.172728519633679 907 3663794 SGTC_228 caffeine 993.056 µM 0.943125472881774 0.14122805683333 no 477 0.172808363932283 822 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_373 0844-0104 25.9 µM 0.942452841208989 0.141399216675477 no 478 0.172980422280938 919 5375804 SGTC_2983 9022671 12.99 µM 0.94180696399055 0.141563700758607 no 479 0.173145739556469 830 6405161 SGTC_2800 7887935 81.82 µM 0.940769747614344 0.141828117453955 no 480 0.173411433596071 813 2961002 SGTC_819 1013-0258 27.7 µM 0.938209506573579 0.14248222847477 no 481 0.17406837691659 855 5753198 SGTC_558 k064-0027 21.3 µM 0.935129346966929 0.143271872551794 no 482 0.174860822077489 884 5088526 SGTC_2341 7987486 176.74 µM 0.93289746004217 0.143845892786136 no 483 0.17543645696428 902 1258686 SGTC_3208 9114115 49.47 µM 0.931949983374026 0.144090043324645 no 484 0.175681187261254 769 650895 SGTC_1405 3909-7894 12 µM 0.931301776151334 0.14425723750186 no 485 0.175848741733845 881 7104060 SGTC_3 0833-0587 95.581 µM 0.930602328014458 0.144437795051599 no 486 0.176029654914385 863 5382644 SGTC_403 arphamenine a 50 µM 0.927959801126523 0.145121318611142 no 487 0.176714211064009 877 5487158 An arginine aminopeptidase inhibitor. SGTC_864 0469-0573 172 µM 0.926356648898834 0.145537053816778 no 488 0.177130332602326 835 689425 SGTC_1769 st044406 64.4 µM 0.924331276374853 0.146063424726862 no 489 0.177656931757477 882 670903 SGTC_1490 4089-0339 670 nM 0.92333270047096 0.146323413210688 no 490 0.177916925836346 866 742542 SGTC_3114 9122766 49.47 µM 0.921112693433131 0.146902525323625 no 491 0.178495796879727 800 17176985 SGTC_576 1073-0113 22.7 µM 0.921042271899564 0.146920920640457 no 492 0.17851417882032 1100 5439563 SGTC_198 3454-2873 16.191 µM 0.920999527548508 0.14693208695422 no 493 0.178525336843039 872 710957 SGTC_2298 7976326 193.81 µM 0.918396338007561 0.147613203729854 no 494 0.179205703597913 824 2235818 SGTC_3326 9140064 16.379 µM 0.917962806906671 0.147726840953248 no 495 0.179319169019997 863 1868434 SGTC_219 mitoxanthrone 164.414 µM 0.917432038519564 0.147866045773817 no 496 0.179458145252418 837 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_844 0330-0132 15.3 µM 0.916673180009244 0.148065224369645 no 497 0.179656962105166 951 2828079 SGTC_2602 kawain 100 µM 0.915602226898846 0.148346624227435 no 498 0.179937781461227 956 5369129 SGTC_2845 9003024 42.97 µM 0.91448421397143 0.148640770765915 no 499 0.180231234501478 904 2990173 SGTC_891 0929-0073 133 µM 0.905888436238783 0.150915316724008 no 500 0.182497452782595 917 5603632 SGTC_594 1487-1584 10.8 µM 0.903861918605797 0.151454914655686 no 501 0.183034312077581 918 5013332 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.90130733950611 0.152136944405661 no 502 0.183712466255553 949 5393153 SGTC_1624 st003710 6.25 µM 0.895430969873862 0.153713567001816 no 503 0.185278375718837 960 24207033 SGTC_2061 5245884 80.95 µM 0.895053133584708 0.153815308785579 no 504 0.185379342675782 918 573863 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.891754290469266 0.154705497154373 no 505 0.186262323420636 963 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2176 5809774 33.9695 µM 0.891644743842096 0.154735116445508 no 506 0.186291689719796 954 2870539 SGTC_945 3381-0768 11.3 µM 0.890360272568408 0.155082692169259 no 507 0.186636233501586 964 1126236 YIL048W NEO1 SGTC_2999 9069765 71.4286 µM 0.88946615846582 0.155324941991346 no 508 0.186876301471891 947 2097066 SGTC_3021 9087658 49.47 µM 0.889377956647128 0.155348852774458 no 509 0.186899993846535 926 25237042 SGTC_2331 7980721 200 µM 0.886954775447273 0.156006707188803 no 510 0.187551624663254 928 2981221 SGTC_1219 1469-0211 33.1 µM 0.883729083523368 0.156885275053594 no 511 0.188421238253019 928 6822282 SGTC_1369 1866-0067 208 µM 0.88178845344602 0.15741540149821 no 512 0.188945608436516 982 3531355 SGTC_188 3229-0966 278.469 µM 0.880654027670945 0.157725839902691 no 513 0.189252553226509 1051 5722370 SGTC_955 1216-0110 33 µM 0.880334205977432 0.157813432515923 no 514 0.18933914373031 898 3619719 SGTC_517 1365-0151 113 µM 0.879418703455145 0.158064346495719 no 515 0.189587147337289 902 768657 SGTC_1520 flindersine 88 µM 0.877913251305389 0.15847751846339 no 516 0.189995398695666 968 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_182 3448-4371 550.524 µM 0.877117681762312 0.158696148689828 no 517 0.190211360817034 1003 3491403 SGTC_1200 1643-0193 18.4 µM 0.874600044081568 0.159389322384098 no 518 0.190895781898223 984 5403974 SGTC_1379 2144-0755 36.5 µM 0.873059884882871 0.159814345654813 no 519 0.191315218801758 1004 5392327 SGTC_727 3032-0951 202 µM 0.872752932860474 0.159899140848226 no 520 0.191398879567841 903 3652836 SGTC_338 4055-0136 114 µM 0.872015529769907 0.160102967967132 no 521 0.191599952766624 950 2900563 SGTC_3176 9106582 49.47 µM 0.869393309034809 0.160829156932902 no 522 0.192316020778475 839 17018027 SGTC_1010 4112-3296 15.2 µM 0.868820587319272 0.160988050242634 no 523 0.192472635370002 989 704384 SGTC_278 4092-0821 23.9 µM 0.868339222952646 0.161121677003316 no 524 0.192604327972908 941 877900 SGTC_3019 9081971 49.47 µM 0.867923760545963 0.161237067550037 no 525 0.192718035256046 1009 16451803 SGTC_2899 9053889 58.44 µM 0.865296571595395 0.161967991089365 no 526 0.19343801603711 948 6470052 SGTC_199 4063-0024 41.6 µM 0.86519318656829 0.161996798432781 no 527 0.193466382207801 982 306215 SGTC_2003 4023581 200 µM 0.863817458355508 0.162380450858223 no 528 0.193844087862041 924 16641307 SGTC_1764 st044502 93.5 µM 0.862873479367192 0.162644042236934 no 529 0.194103516759232 946 8407 SGTC_2063 5246145 200 µM 0.860035066624184 0.163438300468775 no 530 0.194884856396053 982 711240 SGTC_109 0132-0036 33.701 µM 0.859824636093134 0.163497284287109 no 531 0.194942858389027 838 67274 A color developer. SGTC_2651 TUB2.036 5 µM 0.858821966784565 0.163778523006575 no 532 0.195219373153955 1098 15992207 YFL037W TUB2 SGTC_2136 5328288 199.296 µM 0.858610242291174 0.163837949740059 no 533 0.195277792707937 856 262395 SGTC_1552 6-methylflavone 10.6 µM 0.85773687624933 0.164083233622624 no 534 0.195518886319883 943 689013 SGTC_873 0591-4978 488 µM 0.856451492897515 0.164444665154333 no 535 0.195874046361381 1022 3305145 SGTC_2860 9025725 38.96 µM 0.856450225352137 0.164445021824591 no 536 0.195874396785772 896 40546248 SGTC_1 0258-0098 57.368 µM 0.856439162833919 0.164448134690036 no 537 0.195877455135198 840 6790032 YDR047W HEM12 SGTC_1930 st074634 34.3 µM 0.855339795998721 0.164757674379255 no 538 0.196181531156901 1001 684253 YOR116C RPO31 SGTC_426 0988-0037 14.6 µM 0.854579638332655 0.16497192630274 no 539 0.196391951942835 998 5383008 SGTC_3195 9113082 49.47 µM 0.853309091047154 0.165330435124234 no 540 0.196743959969964 956 17018038 SGTC_1115 galangin 695.678 nM 0.852513547061362 0.165555169282168 no 541 0.196964561653858 1052 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_996 3970-0799 1.8 µM 0.850869838341592 0.166020128019013 no 542 0.197420830608445 1136 6615648 YGL040C HEM2 SGTC_2788 5282734 71.43 µM 0.85057239066378 0.166104357635152 no 543 0.197503465879114 1005 743706 SGTC_3069 9117009 49.47 µM 0.848607646655123 0.166661416477691 no 544 0.198049825312723 855 41904981 SGTC_1567 st069303 68.4 µM 0.847047626179681 0.167104582754063 no 545 0.19848428789019 977 5581319 SGTC_1429 4049-0205 9.46 µM 0.845252359921029 0.167615516407087 no 546 0.19898497688862 1009 22774478 SGTC_2642 cholecalciferol 100 µM 0.845139879351193 0.167647561894291 no 547 0.199016372361931 978 9821465 A vitamin D precursor, similar to steriods. SGTC_2463 5473429 200 µM 0.84512236795232 0.16765255121142 no 548 0.199021260396001 948 5399405 SGTC_1279 0874-0590 65.2 µM 0.843300090317948 0.168172274112878 no 549 0.199530316163015 973 3523074 SGTC_43 0570-0105 72.5 µM 0.841563802786436 0.168668435492006 no 550 0.200016078821846 1019 1114046 YDL195W SEC31 SGTC_2540 epiandrosterone 100 µM 0.840782812746152 0.168891917606119 no 551 0.200234808711883 1140 441302 A steroid. SGTC_918 glabranin 770.725 nM 0.84028357254458 0.169034875972955 no 552 0.200374704921192 978 124049 Also referred to as licorice root. SGTC_3181 9108277 49.47 µM 0.836657582021668 0.17007551629435 no 553 0.201392534349404 981 17097298 SGTC_2149 5554786 194.827 µM 0.833203272532402 0.171070695648148 no 554 0.202365048634906 1021 745063 YPR165W RHO1 SGTC_2077 5212015 200 µM 0.83318732088604 0.171075299906697 no 555 0.202369546110722 945 780900 SGTC_2487 5918373 44.05 µM 0.829667130684815 0.172093300569956 no 556 0.203363505145266 1054 2876279 SGTC_2199 6590217 200 µM 0.827561514085631 0.172704066173872 no 557 0.203959435726427 951 703109 SGTC_342 k048-0088 23.3 µM 0.826994466647864 0.172868782652434 no 558 0.204120098885012 1002 6820570 SGTC_3058 9093861 49.47 µM 0.824851397717533 0.17349220713771 no 559 0.204727981150738 983 17217477 SGTC_1290 0986-0249 10.2 µM 0.823479050693395 0.173892177145615 no 560 0.20511781280593 1006 53329 SGTC_258 haloperidol 50.781 µM 0.823336289892693 0.17393381837202 no 561 0.205158391042512 988 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2114 5491910 81.25 µM 0.82194608467621 0.174339652256749 no 562 0.205553791406875 999 2849228 SGTC_496 calpeptin 138 µM 0.820174654473473 0.174857645705862 no 563 0.206058274275652 961 73364 A calpain inhibitor. SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.818221192474179 0.175429999314618 no 564 0.206615448096426 1004 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2977 9011197 71.43 µM 0.817780145205009 0.175559387890328 no 565 0.206741368623825 935 2704722 SGTC_168 3970-0862 530.542 µM 0.817005210283 0.17578687442415 no 566 0.206962725255288 1098 3135186 SGTC_2643 anethole 100 µM 0.814941793241024 0.176393512209016 no 567 0.207552814433816 1053 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3106 9121286 49.47 µM 0.814719165822584 0.17645904300022 no 568 0.207616540056125 991 15943471 SGTC_2636 apigenin dimethyl ether 100 µM 0.814393170862001 0.176555027999314 no 569 0.207709874807952 996 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2053 5265679 138 µM 0.81434801707135 0.176568325551988 no 570 0.207722804624024 1041 764595 SGTC_588 3970-1144 52.9 µM 0.81416442812609 0.176622398048738 no 571 0.207775380329169 1004 1888707 SGTC_1310 1188-0297 994 nM 0.813920640446595 0.176694217076 no 572 0.207845207731943 1000 1588352 SGTC_3340 9146634 11.102 µM 0.812215611905043 0.177197028760322 no 573 0.208333961424479 1011 4907387 SGTC_893 0958-0369 48.9 µM 0.810733574913327 0.177634813794286 no 574 0.208759343894582 1043 6819948 SGTC_115 0527-0192 112.043 µM 0.810567829864713 0.177683816307267 no 575 0.208806948758623 1062 4233931 SGTC_1482 3346-2049 8.48 µM 0.810439922737773 0.177721637871366 no 576 0.208843690285195 1016 3826804 SGTC_1208 2323-2347 50.3 µM 0.809970689884303 0.177860431414136 no 577 0.208978510787204 1037 5412760 SGTC_356 1634-0012 32.5 µM 0.808602309832654 0.178265572345219 no 578 0.209371967869603 1055 735457 SGTC_2212 7123476 200 µM 0.807813916324481 0.178499258544274 no 579 0.209598856350198 978 1085715 SGTC_280 3448-3607 3.04 µM 0.807175862040768 0.178688524190512 no 580 0.209782585162966 1029 626179 SGTC_328 k915-0120 63.5 µM 0.807062293950733 0.178722225064663 no 581 0.209815297210391 1014 6624543 SGTC_2430 5571206 200 µM 0.805538998350249 0.179174643663747 no 582 0.210254355635911 1126 1731771 SGTC_3278 9139605 49.47 µM 0.804479440438592 0.179489756639993 no 583 0.210560069189549 1008 7958859 SGTC_1941 st076221 61.8 µM 0.804333429820779 0.179533207553907 no 584 0.210602217978571 1059 2828568 SGTC_3261 9137475 49.47 µM 0.803656527926708 0.179734731359704 no 585 0.210797683469466 878 17027690 SGTC_2185 6113692 200 µM 0.801215024041798 0.180462783665227 no 586 0.211503587479948 989 874150 SGTC_54 0159-0055 9 µM 0.800923130953489 0.180549949329469 no 587 0.211588074104403 1036 3319099 SGTC_1508 1080-0625 72.9 µM 0.800549140662846 0.180661669598854 no 588 0.211696352118197 987 767111 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.798716802205445 0.181209661251304 no 589 0.212227320910262 1119 23665772 A membrane-active detergent. SGTC_413 propylparaben 100 µM 0.796622151827649 0.181837375527413 no 590 0.212835254128398 1001 7175 A pharmaceutical preservative. SGTC_444 curcumin 90.4 µM 0.795118781128662 0.182288735424557 no 591 0.213272205334039 1002 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1654 st012436 41.8 µM 0.795036464033388 0.182313469846001 no 592 0.213296145701729 1011 4323132 SGTC_1117 retinoic acid 1.10837 µM 0.794567002768952 0.18245457239805 no 593 0.21343270956351 1074 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2663 amphotericin b 100 µM 0.79447392369117 0.182482556599975 no 594 0.213459791840111 1049 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.793147866785186 0.182881526416734 no 595 0.213845838659687 1025 756377 SGTC_2647 atorvastatin 60.16 µM 0.792722539721431 0.18300960949946 no 596 0.213969747579795 1014 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2841 9004761 38.96 µM 0.791411083359944 0.183404893991053 no 597 0.214352072203547 1026 2991039 SGTC_2215 7188065 200 µM 0.789563128184668 0.183962786598632 no 598 0.214891474397087 1057 940217 SGTC_173 1273-0061 2.693 µM 0.787600935909349 0.184556322467749 no 599 0.215465083541026 1038 2847414 YPL266W DIM1 SGTC_1596 piperlongumine 63 µM 0.783660388011881 0.185751875788366 no 600 0.216619705779872 1093 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2065 5221596 34.26 µM 0.783461649184426 0.185812299686995 no 601 0.216678033010917 1022 788581 SGTC_2786 7743617 45.45 µM 0.781886931644896 0.186291502512 no 602 0.217140512912292 981 583674 SGTC_1002 4049-0206 172 µM 0.781826232871646 0.186309989089932 no 603 0.217158350985138 1120 4662749 SGTC_3253 9135987 49.47 µM 0.780795780432881 0.186623999808352 no 604 0.217461308097071 1010 4182430 SGTC_3323 9138564 53.9225 µM 0.780681242848971 0.186658923176029 no 605 0.217494997662819 1123 43912313 YNL103W MET4 SGTC_427 1354-0053 47.3 µM 0.778799342326968 0.187233307995864 no 606 0.218048962607589 1035 6813657 SGTC_604 1000-0114 314 µM 0.778727959563343 0.187255116599673 no 607 0.218069991167071 1110 1572745 SGTC_1568 digitonin 820 nM 0.77831214429822 0.18738218619671 no 608 0.218192508904609 1096 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1262 0737-0114 49.6 µM 0.776188839645972 0.188031880657831 no 609 0.218818747337018 1123 765919 SGTC_2778 tioconazole 65.09 nM 0.776013013929083 0.188085742552377 no 610 0.21887065094997 1037 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1726 st035556 14.5795 µM 0.77600063748228 0.188089534272705 no 611 0.218874304734124 1091 5919439 SGTC_1411 3909-8223 150 µM 0.774053833833608 0.188686555658757 no 612 0.219449478356901 1130 X1411 SGTC_2671 danthron 100 µM 0.773026729812154 0.189002005255669 no 613 0.219753280807571 1060 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2638 epoxomicin 18 µM 0.77284971695897 0.189056403175302 no 614 0.219805663019384 1072 9915668 A protesome inhibitor. SGTC_3310 9130229 44.1445 µM 0.772819004926228 0.189065842289007 no 615 0.219814752152309 1052 7761258 SGTC_2894 9048625 32.47 µM 0.771686175212065 0.189414211820028 no 616 0.22015016037565 1109 4092861 SGTC_2261 9010538 184.68 µM 0.771351430536624 0.189517228584665 no 617 0.220249327734042 1009 6457250 SGTC_1778 st046819 58.9 µM 0.770882200126955 0.189661690988375 no 618 0.220388379296608 1156 671715 SGTC_3235 9132602 49.47 µM 0.77032071606973 0.189834644603302 no 619 0.22055483538453 1123 4912240 SGTC_2842 9000675 19.48 µM 0.769600186878094 0.190056730823312 no 620 0.220768547069467 1075 2989072 SGTC_2406 ethylparaben 405.7 µM 0.769544052083457 0.190074039759129 no 621 0.220785201839914 987 8434 A possible steroid mimic. SGTC_158 k038-0087 26.446 µM 0.768474460654122 0.190404028996415 no 622 0.221102678988225 1084 X158 SGTC_1553 gossypol 38.6 µM 0.767804768602169 0.190610820689533 no 623 0.221301590529189 1035 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2978 9011784 42.97 µM 0.767738522884177 0.190631283946598 no 624 0.221321272354669 1165 2994934 SGTC_2450 5739737 12.93 µM 0.767211362986696 0.19079417133634 no 625 0.221477929006784 1053 2262825 SGTC_798 1287-0182 476 µM 0.766966377727255 0.19086989850734 no 626 0.221550753099287 1148 1649755 SGTC_2967 9089538 49.85 µM 0.76628166385277 0.191081647563327 no 627 0.221754363081828 1116 728216 SGTC_2870 9038528 12.99 µM 0.766227802318943 0.191098310453498 no 628 0.221770384154116 1048 6463316 SGTC_3152 9099253 49.47 µM 0.765853782094505 0.191214043911398 no 629 0.221881654422116 1124 25236131 SGTC_506 n9-isopropylolomoucine 153 µM 0.765727461196474 0.191253141219991 no 630 0.22191924183789 1085 6610355 SGTC_134 0269-0018 6.916 µM 0.76103725464469 0.192708263803875 no 631 0.223317407861267 1012 4378915 SGTC_1560 lithocholic acid 53.1 µM 0.759900867491193 0.193061840027342 no 632 0.223656921525073 1054 9903 A bile acid which acts as a detergent. SGTC_1375 2910-0797 186 µM 0.759576809168061 0.193162740277964 no 633 0.223753792837625 1075 742508 SGTC_2497 7-hydroxyflavone 100 µM 0.759359189855813 0.193230517265455 no 634 0.223818859538236 1021 5281894 SGTC_3265 9137266 49.47 µM 0.758402102959984 0.193528771831704 no 635 0.224105149663441 1073 17224265 SGTC_2030 5175110 200 µM 0.757910435103435 0.193682098157453 no 636 0.224252301418053 1130 2831986 SGTC_2748 diazoxide 86.69 µM 0.757520755492623 0.193803672110547 no 637 0.224368967971246 1025 3019 A potassium channel activatior. SGTC_584 0986-0246 15.4 µM 0.757422966861187 0.193834187936425 no 638 0.224398250410213 1205 53315 YDR232W HEM1 SGTC_1666 st014829 29 µM 0.751367485895176 0.195729557418636 no 639 0.226215762416578 1144 3858230 SGTC_1138 3761-0006 1.03 µM 0.751337951558828 0.195738829167242 no 640 0.22622464728403 1105 12061087 SGTC_1090 efavirenz 20.7 µM 0.749930437953562 0.196181000587104 no 641 0.226648300659338 1101 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2363 9053361 176 µM 0.749428353901104 0.19633887711051 no 642 0.226799533313137 1131 6469797 YMR079W SEC14 SGTC_2020 4017018 200 µM 0.74654985275217 0.197245485542591 no 643 0.227667664177442 1134 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_3199 9111318 49.47 µM 0.745381184757264 0.197614289142618 no 644 0.228020657477703 1056 8548020 SGTC_2664 lyso-paf C-16 73.48 µM 0.744939842232252 0.197753674620526 no 645 0.228154043939484 1135 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3260 9137109 49.47 µM 0.743346495236156 0.198257382119946 no 646 0.228635964362787 986 17478346 SGTC_1871 st057448 67.3 µM 0.742967492200098 0.198377310910354 no 647 0.2287506809378 1178 691747 SGTC_546 peri-Naphthalide 147 µM 0.742773498069816 0.198438713847761 no 648 0.228809411549336 1085 223824 A penicillin ester. SGTC_1967 st070177 51.4 µM 0.742718152987051 0.198456233751381 no 649 0.228826168507794 1127 5729214 SGTC_3270 9137563 49.47 µM 0.742301335076954 0.198588210584523 no 650 0.228952391555716 1063 17015724 SGTC_1106 tegaserod maleate 11.7 µM 0.741223057744459 0.198929870478818 no 651 0.229279102510978 1125 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_791 1348-1292 225 µM 0.741207167325221 0.198934908119325 no 652 0.229283919157334 1154 5437054 SGTC_1644 st010134 20.9 µM 0.739612445403585 0.199440863816806 no 653 0.229767593935276 1114 3818134 SGTC_2305 7443522 69.23 µM 0.736203759174136 0.200524928297313 no 654 0.23080335243643 1115 5415886 SGTC_394 menadione 8.33 µM 0.735840610036453 0.200640628825973 no 655 0.230913851907436 1112 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2045 5106652 78.05 µM 0.734831907057616 0.200962215176788 no 656 0.231220936220711 1128 673349 SGTC_3014 9081533 49.47 µM 0.733544297597134 0.201373169187538 no 657 0.231613260208122 1136 21367265 SGTC_1594 piperine 70.1 µM 0.733474376683561 0.201395499587055 no 658 0.23163457514929 1127 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2270 7924575 90.91 µM 0.733428905190568 0.20141002245636 no 659 0.231648437428342 1126 1262135 SGTC_3224 9130643 49.47 µM 0.732940153726805 0.201566161501617 no 660 0.231797465664331 1162 17644395 SGTC_937 3122-0005 46.7 µM 0.731892412043003 0.201901122692077 no 661 0.232117118970245 1146 759535 SGTC_2563 tomatine 8.54 µM 0.731529377381147 0.202017261932358 no 662 0.232227933662205 1135 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2382 9035899 200 µM 0.731196769269626 0.202123702435988 no 663 0.232329486623323 1183 6462679 SGTC_327 1273-0057 3.96 µM 0.730132400102558 0.20246454491962 no 664 0.232654629156038 1093 3108138 SGTC_1007 4101-0031 70 µM 0.729184652176227 0.202768330876099 no 665 0.232944359091862 1127 1146276 SGTC_1225 1216-0074 20.6 µM 0.728309260063772 0.203049166098348 no 666 0.233212147541907 1129 4241466 SGTC_1348 1493-0373 93.8 µM 0.727653044814818 0.203259839245166 no 667 0.233413000288938 1131 3010129 SGTC_2879 9041815 71.43 µM 0.727367647972009 0.203351504522933 no 668 0.233500383787027 1100 4942971 SGTC_3042 9091578 49.47 µM 0.727233763142288 0.203394514864135 no 669 0.233541383220914 1115 25236497 SGTC_3292 9120825 59.784 µM 0.726849526301259 0.203517980625639 no 670 0.23365906989909 1178 24824900 SGTC_2617 dihydrotanshinone i 20.83 µM 0.725849551987047 0.203839509094516 no 671 0.233965502923314 1184 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2520 obtusaquinone 4.71 µM 0.724994053498458 0.204114823440045 no 672 0.234227839253373 1202 5967872 SGTC_889 0919-1524 82.7 µM 0.7249318457367 0.204134851618444 no 673 0.234246921446566 1122 3905452 SGTC_3127 9126946 49.47 µM 0.723976597710397 0.204442546669462 no 674 0.234540051245064 1050 27243249 SGTC_2797 7859098 81.82 µM 0.723436072425407 0.204616777559795 no 675 0.234706008034192 1184 972681 SGTC_606 k015-0008 38.6 µM 0.720750222798078 0.205483833491967 no 676 0.23553160313258 1205 1970475 SGTC_1073 triclabendazole 3.09 µM 0.719719248631286 0.205817234985987 no 677 0.23584893617693 1202 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2695 st077686 51.995 µM 0.718424578538592 0.20623636605136 no 678 0.236247768231181 1161 2876092 SGTC_1825 st052143 62.6 µM 0.716304507073024 0.206923800645304 no 679 0.236901672203609 1151 674173 SGTC_2740 felodipine 17.08 µM 0.715388923288715 0.20722109809342 no 680 0.237184377519187 1105 3333 L-type calcium channel blocker SGTC_974 1326-0144 138 µM 0.71509346615545 0.207317089296744 no 681 0.237275645520067 1188 5411856 SGTC_649 1123-0311 367 µM 0.714134645336769 0.207628782086537 no 682 0.237571962286597 1155 693629 YIL048W NEO1 SGTC_568 1193-0097 7.48 µM 0.712696116681523 0.208096936933661 no 683 0.238016909998778 1096 3646150 SGTC_1970 st070122 35.8 µM 0.71242039914489 0.208186737561534 no 684 0.23810224363911 1206 102928 SGTC_2588 indole-3-carbinol 100 µM 0.711029084635146 0.208640234516773 no 685 0.238533106410084 1160 3712 Induces cell cycle arrest. SGTC_3105 9121040 49.47 µM 0.710264461287786 0.208889710144619 no 686 0.238770076846611 1023 41448907 SGTC_780 0109-0199 192 µM 0.708856584730607 0.209349521073088 no 687 0.239206739622932 1207 610414 SGTC_2277 7947813 106.88 µM 0.708808776399041 0.209365145671006 no 688 0.239221575368459 1178 1246798 SGTC_3255 9139072 49.47 µM 0.707799666315412 0.209695100554366 no 689 0.239534836812629 1198 17646060 SGTC_3089 9117425 49.47 µM 0.707500560780709 0.20979295963383 no 690 0.239627732162868 1140 9401657 SGTC_1779 st039427 55 µM 0.706076121112342 0.210259365239368 no 691 0.240070400292046 1229 1124498 SGTC_76 0433-0009 400.328 µM 0.705993506791717 0.210286434392269 no 692 0.240096087726128 1100 2841569 SGTC_2948 9070189 9.45 µM 0.705786528830705 0.210354261136296 no 693 0.240160450371649 1092 6473636 YDL196W YDL196W SGTC_2259 7964009 200 µM 0.704621501231743 0.210736280606902 no 694 0.240522907116554 1190 313134 SGTC_72 0744-0168 198.391 µM 0.703605051510817 0.211069912689914 no 695 0.240839382310076 1116 677577 SGTC_3164 9100705 49.47 µM 0.702164862813124 0.211543159488204 no 696 0.2412881777599 1181 17174235 SGTC_564 3555-0129 330 µM 0.701677835832218 0.211703337279041 no 697 0.241440049172835 1101 563260 SGTC_67 0335-0847 266 µM 0.699960724447656 0.212268642250041 no 698 0.241975916337362 1237 4552207 YOR254C SEC63 SGTC_1698 5-fluorocytosine 1.055 µM 0.697129623721397 0.213202617242835 no 699 0.242860838314681 1213 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1041 0206-0046 107 µM 0.696953286703756 0.213260869682506 no 700 0.242916014150909 1162 50494 SGTC_1729 st035615 45.989 µM 0.694924462780336 0.213931753346535 no 701 0.243551320597632 1147 17385451 SGTC_500 h-89 112 µM 0.694515115011425 0.214067263698005 no 702 0.243679612577145 1227 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_439 amiodarone 34.4 µM 0.693213611690474 0.214498444710154 no 703 0.244087753628554 1151 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2583 asiatic acid 100 µM 0.693076986611779 0.214543737126746 no 704 0.244130619534896 1224 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2669 eugenol 100 µM 0.692038845473514 0.214888071632888 no 705 0.244456467280983 1170 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1096 rimcazole 32.2 µM 0.691957821160834 0.214914959575573 no 706 0.244481908734862 1142 18528119 A dopamine reuptake inhibitor. SGTC_2163 5671233 125 µM 0.691721128005215 0.214993517462117 no 707 0.244556238028567 1243 701023 SGTC_2645 abamectin 100 µM 0.690489255065156 0.215402642261021 no 708 0.244943282363333 1196 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_24 0417-1663 219 µM 0.68994237876588 0.215584413336309 no 709 0.245115211974601 1192 4329390 SGTC_2303 7774051 200 µM 0.689595654222281 0.215699703910499 no 710 0.245224250521211 1191 2953184 SGTC_1738 st035555 74 µM 0.689429598482995 0.215754932333426 no 711 0.245276481257848 1213 5331140 SGTC_2938 9059746 27.26 µM 0.688972976062909 0.21590684248507 no 712 0.245420136904087 1154 6471769 SGTC_3024 9090631 49.47 µM 0.68836874123198 0.216107955895131 no 713 0.245610301615411 1167 25236383 SGTC_11 0438-0307 1.3 µM 0.688157939416021 0.216178144653437 no 714 0.245676663753493 1204 4011476 SGTC_2187 6125751 200 µM 0.688117032734152 0.216191766507458 no 715 0.245689542627403 1188 874498 SGTC_2750 bromebric acid 70.15 µM 0.687340201532413 0.216450544274077 no 716 0.245934185433229 1221 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_486 niguldipine 82 µM 0.686989055826395 0.216567576622311 no 717 0.246044812535289 1211 1236 A calcium channel blocker. SGTC_1673 st016611 27.3 µM 0.68698852675615 0.216567752982236 no 718 0.246044979236971 1217 5226799 SGTC_2138 5575593 77.673 µM 0.686242031444503 0.216816671986289 no 719 0.246280248467521 1202 762213 SGTC_1094 duloxetine 25.4 µM 0.683614904375267 0.21769400237749 no 720 0.247109185312485 1214 60834 A selective serotonin reuptake inhibitor. SGTC_2124 5246320 200 µM 0.683360134426351 0.217779191738762 no 721 0.247189652126214 1209 579342 SGTC_225 nsc-122657 1.016 µM 0.683200557487645 0.217832560484031 no 722 0.247240060213837 1153 275685 SGTC_1898 st060199 18.6 µM 0.68252239752652 0.218059447723708 no 723 0.247454342609029 1241 688866 SGTC_1914 st062367 72.6 µM 0.681852492433971 0.21828370688028 no 724 0.247666114064131 1215 978205 SGTC_3052 9092717 49.47 µM 0.68015497733268 0.218852565995721 no 725 0.248203168314626 1225 25237534 SGTC_1291 0993-0025 5.79 µM 0.679893586137916 0.2189402372621 no 726 0.248285921546478 1230 4353356 SGTC_700 3453-2283 142 µM 0.678198120358805 0.21950939104105 no 727 0.248823042089835 1286 565664 SGTC_69 0096-0274 206.684 µM 0.677812613913666 0.219638920845731 no 728 0.248945256105702 1346 6741392 SGTC_1018 4259-0013 28.1 µM 0.677200107318346 0.219844812731245 no 729 0.249139499840266 1217 6801262 SGTC_1521 st012942 49.4 µM 0.675957821045374 0.220262742796166 no 730 0.249533712541315 1262 24207259 SGTC_508 roscovitine 141 µM 0.674475268008466 0.220762099142017 no 731 0.250004602122422 1261 160355 A CDKinase inhibitor. SGTC_3300 9124615 50.48 µM 0.673497150560299 0.221091905187286 no 732 0.25031553047027 1258 24824903 SGTC_3043 9092303 49.47 µM 0.673126012121864 0.221217121064762 no 733 0.250433563248004 1189 25236084 SGTC_2703 st077852 53.4 µM 0.672584810314356 0.221399786156481 no 734 0.250605733959624 1226 6281836 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.672501125613438 0.221428038906007 no 735 0.250632361888449 1247 3256 An antibiotic and ribosome inhibitor. SGTC_932 2857-0803 154 µM 0.672488677527005 0.221432241674278 no 736 0.250636322916821 1302 674898 SGTC_1616 st002734 56.1 µM 0.671313617709797 0.2218291749507 no 737 0.251010380665114 1208 4026101 SGTC_2858 9025781 8.96 µM 0.671287880177764 0.221837873592716 no 738 0.251018577019235 1262 4894980 YPL153C RAD53 SGTC_1173 0443-0020 122 µM 0.67000953220403 0.222270168320119 no 739 0.251425856837576 1239 5331295 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.669532014873294 0.222431772007215 no 740 0.25157808271767 1338 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_770 0389-1121 67.2 µM 0.668842912896519 0.222665099264682 no 741 0.251797844640615 1308 6753108 SGTC_973 1325-0077 65.9 µM 0.668370416367916 0.222825165350676 no 742 0.251948587342996 1272 2835149 SGTC_2837 9008476 45.46 µM 0.66823657916107 0.222870516851397 no 743 0.251991294685922 1254 2992805 SGTC_1182 1222-0449 220 µM 0.667910950998454 0.222980879770458 no 744 0.252095218316857 1225 658318 SGTC_723 4182-0001 115 µM 0.667875257260763 0.222992979096802 no 745 0.252106611282614 1204 744821 YLR208W SEC13 SGTC_965 1291-5240 308 µM 0.667369464895626 0.223164470839941 no 746 0.252268082659149 1238 2834598 SGTC_2446 5162541 200 µM 0.667161894437107 0.223234870493588 no 747 0.2523343641419 1210 1549321 SGTC_3183 9108214 49.47 µM 0.666749855805297 0.223374655075093 no 748 0.252465963679429 1159 4974831 SGTC_451 chloral hydrate 100 µM 0.665865335583684 0.223674897738107 no 749 0.252748589523792 1302 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2211 7117706 200 µM 0.663847858075502 0.224360570716813 no 750 0.253393845742817 1202 822771 SGTC_19 0279-0214 38.434 µM 0.66375347183902 0.224392678623151 no 751 0.253424054778297 1296 3566274 YBR002C RER2 SGTC_309 k408-0051 1.48 µM 0.663628039130474 0.224435351821178 no 752 0.253464203402961 1231 3640463 SGTC_2738 aclarubicin 5.55 µM 0.661540691973337 0.225146159499299 no 753 0.254132813837306 1160 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_326 k292-0812 17.5 µM 0.661454443294601 0.225175557311783 no 754 0.25416046054603 1225 3579357 SGTC_2928 9011484 9.79 µM 0.660905560107672 0.225362694773666 no 755 0.25433644006293 1238 2994751 SGTC_183 3914-0051 30.55 µM 0.659554387567055 0.225823741567657 no 756 0.254769916594549 1243 1596232 SGTC_2927 9011802 47.9 µM 0.657913417537812 0.226384389647603 no 757 0.255296884187556 1243 43912568 SGTC_1298 1079-1278 263 µM 0.654392170658367 0.227590095869944 no 758 0.256429588626353 1281 2840950 SGTC_2811 7967822 32.47 µM 0.654309641460097 0.227618397898422 no 759 0.256456167749449 1284 2232244 SGTC_538 2922-0838 53.3 µM 0.653251945891119 0.227981292549982 no 760 0.256796933266013 1298 777039 SGTC_871 0574-0004 149 µM 0.652969185702175 0.228078362487454 no 761 0.256888072092409 1254 9551173 SGTC_2156 5649887 115 µM 0.652521952543561 0.228231942488503 no 762 0.257032257949162 1304 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_827 3253-0474 693 µM 0.652019407271711 0.228404586029705 no 763 0.257194326381831 1264 5402065 SGTC_1312 1218-2183 165 µM 0.651948719211884 0.228428875970157 no 764 0.257217127202531 1276 6744073 SGTC_314 1671-0008 2.74 µM 0.65083394737044 0.228812127468558 no 765 0.257576841874342 1200 3913060 SGTC_586 0957-0265 8.15 µM 0.649039244062594 0.22942989272489 no 766 0.258156505279535 1180 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2325 6158266 200 µM 0.648383059433541 0.229655995003214 no 767 0.258368612217801 1282 3623240 SGTC_547 1120-0019 610 nM 0.64739665733909 0.229996115395442 no 768 0.258687629374518 1249 3676939 SGTC_2764 methyldopa 94.69 µM 0.647253090318637 0.230045642097062 no 769 0.258734078084273 1302 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3201 9113999 49.47 µM 0.645907723928659 0.230510046653147 no 770 0.259169558565174 1292 16649224 SGTC_217 ketoconazole 989 nM 0.643732235356272 0.231262107076829 no 771 0.259874541430347 1220 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1652 st011932 78 µM 0.643011462074493 0.23151157796172 no 772 0.26010833123113 1254 1551076 SGTC_786 4544-0069 423 µM 0.642484798003681 0.231693959440653 no 773 0.260279228359873 1321 748821 YLR208W SEC13 SGTC_578 3460-0051 92 µM 0.641558766772702 0.2320148340901 no 774 0.260579856300373 1335 2876744 SGTC_1437 4092-1038 11.6 µM 0.640912700474292 0.232238845874595 no 775 0.260789701885463 1266 3977136 SGTC_692 k241-0027 77.8 µM 0.640325178283099 0.232442662994583 no 776 0.260980607504188 1352 3600480 SGTC_3291 9121177 71.43 µM 0.63941146913405 0.232759835088706 no 777 0.261277644891341 1237 17015612 SGTC_746 1095-0025 46.6 µM 0.638870519742628 0.232947725906933 no 778 0.261453583757322 1274 6749286 SGTC_1976 st070609 63.5 µM 0.638717803501379 0.233000784892729 no 779 0.261503264333872 1233 682556 SGTC_684 1140-0066 328 µM 0.63794906911369 0.233267972117913 no 780 0.261753417194737 1271 6813534 SGTC_1196 1588-0294 184 µM 0.637189948382508 0.233531984725563 no 781 0.26200056210459 1274 6144269 SGTC_2461 5755302 26.15 µM 0.635947227276144 0.233964544922793 no 782 0.262405409558833 1337 2788904 SGTC_1456 k015-0012 13 µM 0.635761363298482 0.234029277668739 no 783 0.262465986918887 1340 2989616 SGTC_808 0711-0032 135 µM 0.635384235657289 0.234160654244461 no 784 0.262588923518539 1268 4252555 SGTC_237 nikkomycin 200 µM 0.634883876908853 0.23433502274982 no 785 0.262752076641394 1338 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_994 3910-0338 138 µM 0.634858236412278 0.234343960064043 no 786 0.262760438693269 1364 3479481 SGTC_1971 st069429 63.5 µM 0.634275680203875 0.234547068106355 no 787 0.262950462530225 1277 1246522 YGL099W LSG1 SGTC_1079 idarubicin 2.36 µM 0.633249006513806 0.234905254473604 no 788 0.263285523835144 1272 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2606 farnesol 9.78 µM 0.631878762445675 0.235383776418616 no 789 0.263733050911079 1323 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_492 tmb-8 126 µM 0.631857915997945 0.235391060648491 no 790 0.26373986243743 1200 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_201 4262-0159 12.803 µM 0.631087181620514 0.235660460341164 no 791 0.263991760995523 1267 1341029 SGTC_3003 9075612 71.4286 µM 0.630255595670204 0.235951320493687 no 792 0.264263685075685 1296 6501993 SGTC_2780 5215298 71.43 µM 0.629441221514452 0.236236352196323 no 793 0.264530119154088 1290 2834131 SGTC_3142 9086498 49.47 µM 0.628394377469403 0.236603026950347 no 794 0.264872809715137 1243 25236367 SGTC_563 tetrahydrosecaminediol 614 µM 0.627092627871229 0.237059423119437 no 795 0.265299259641803 1343 334274 A psychoactive constituent of the cannabis plant. SGTC_667 1498-1044 59 µM 0.625357319042706 0.237668577654384 no 796 0.265868283980389 1336 6739982 SGTC_2148 5546263 113.568 µM 0.623879412315161 0.238188051415724 no 797 0.266353390915903 1299 792097 SGTC_2345 9052315 157.45 µM 0.622901829789282 0.238532006308848 no 798 0.266674517768016 1313 6469265 SGTC_2707 st078556 66.6 µM 0.62079599792582 0.239273849832403 no 799 0.267366928394314 1301 17250899 SGTC_3314 9135860 59.4275 µM 0.619757201750356 0.239640261211794 no 800 0.267708824773759 1306 25252478 SGTC_2073 5212005 126 µM 0.6189502977375 0.239925089182059 no 801 0.267974551021344 1218 691789 SGTC_1084 voriconazole 435 nM 0.618723583466412 0.24000514996302 no 802 0.268049235507822 1314 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2690 usnic acid 100 µM 0.618251010841907 0.240172078792165 no 803 0.268204944624576 1392 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2571 chrysanthemic acid 100 µM 0.617494742911131 0.240439350127596 no 804 0.268454223867407 1263 2743 An insecticide. SGTC_3090 9117696 49.47 µM 0.616614929172128 0.240750487310836 no 805 0.268744372505356 1332 7923821 SGTC_3266 9136860 49.47 µM 0.616425244777712 0.24081759596778 no 806 0.268806948051559 1254 4871271 YPR165W RHO1 SGTC_3040 9091894 49.47 µM 0.616386056685957 0.240831461635658 no 807 0.268819876839166 1253 25236966 SGTC_1841 st054148 70 µM 0.612385264721198 0.242249319123385 no 808 0.27014144431565 1268 675442 SGTC_3200 9114385 49.47 µM 0.611377949914246 0.242607017305175 no 809 0.270474698445671 1291 17018030 YLR208W SEC13 SGTC_1686 st019653 115.5 µM 0.610021493010938 0.243089147603879 no 810 0.270923785028928 1356 97252 SGTC_417 st075190 100 µM 0.608532711005148 0.243618906546631 no 811 0.271417108819309 1377 222757 SGTC_1783 st039459 87.517 µM 0.60769631933723 0.243916796246022 no 812 0.271694452322686 1418 729761 SGTC_3133 9127736 49.47 µM 0.606809259493744 0.244232946586945 no 813 0.271988751222906 1345 27243420 SGTC_3334 9142812 21.919 µM 0.605720694930016 0.244621215405764 no 814 0.272350119652176 1380 45283678 SGTC_989 1501-0895 10.3 µM 0.604835396744314 0.244937228185245 no 815 0.272644185940076 1343 2830112 SGTC_3071 9117417 49.47 µM 0.603511514150001 0.245410206004912 no 816 0.273084229048527 1292 45595590 YGL055W OLE1 SGTC_2140 5586273 200 µM 0.602976711254155 0.245601411817946 no 817 0.273262091052224 1332 854421 SGTC_2278 7948257 134.34 µM 0.602279570910767 0.245850777535932 no 818 0.273494028533867 1301 1247028 SGTC_3025 9087895 49.47 µM 0.601440346053875 0.246151146776007 no 819 0.273773366506364 1338 17173641 SGTC_2541 muurolladie-3-one 83.07 µM 0.601184542303278 0.246242741311041 no 820 0.273858539438766 1349 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2634 4'-methoxyflavone 100 µM 0.599958619529133 0.246681955669933 no 821 0.274266906912222 1352 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_855 0428-0020 25 µM 0.599302421679238 0.246917225552305 no 822 0.274485616642603 1325 6812414 SGTC_2201 6605497 169.863 µM 0.59851451542986 0.247199876086489 no 823 0.274748338233903 1356 670741 SGTC_333 3486-0131 40.1 µM 0.598083157674329 0.247354693012895 no 824 0.274892223830816 1411 6744690 SGTC_587 k089-0003 57 µM 0.597031929765669 0.247732202068853 no 825 0.275243031500923 1306 9659696 SGTC_1068 loratadine 26.9 µM 0.596709238299795 0.247848146283357 no 826 0.275350761799633 1336 3957 A H1 histamine antagonist. SGTC_325 2810-4341 181 µM 0.595632357023765 0.248235283173215 no 827 0.275710427885199 1368 774970 SGTC_3136 9095672 49.47 µM 0.595276489638309 0.248363287709996 no 828 0.275829334284955 1220 17217380 SGTC_1677 st019204 53.9 µM 0.594485391655592 0.248647969515522 no 829 0.276093755043087 1309 3945625 SGTC_898 1000-0849 28.3 µM 0.594383528498065 0.248684638268098 no 830 0.27612781136301 1331 6751807 SGTC_3100 9120536 49.47 µM 0.594090981555635 0.248789965479819 no 831 0.276225631225327 1273 16421196 SGTC_2130 NSC 7 2.4545 µM 0.593114769161053 0.249141608150076 no 832 0.27655217350514 1369 21448 SGTC_2747 doxorubicin 7.63 µM 0.59278312879606 0.249261128866914 no 833 0.276663149995419 1269 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2167 5876490 200 µM 0.592640798692613 0.249312432924245 no 834 0.276710784470341 1521 686534 SGTC_642 0335-0876 158 µM 0.591923219876902 0.249571175592877 no 835 0.276951002088034 1364 6812350 SGTC_1489 4065-0444 182 µM 0.591783713587667 0.249621494959512 no 836 0.276997715246348 1342 2877968 SGTC_3139 9095020 49.47 µM 0.591485405165176 0.249729111707598 no 837 0.27709761564384 1180 25236292 SGTC_953 1188-0045 9.7 µM 0.591196734995068 0.249833274843784 no 838 0.277194305073943 1397 6144426 SGTC_1145 3546-0597 10.2 µM 0.590678293417343 0.250020406105402 no 839 0.277367997354744 1348 875334 SGTC_2751 anetholtrithion 17.25 µM 0.589755882913512 0.250353533563593 no 840 0.277677161915587 1362 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_421 streptovitacin 30 mM 0.588735778165341 0.250722216996569 no 841 0.27801926657413 1391 91467 include heat shock SGTC_597 k018-0003 82.8 µM 0.588579941176604 0.250778564475428 no 842 0.2780715465248 1458 6786234 SGTC_3306 9127676 59.7925 µM 0.588371040404276 0.250854109254128 no 843 0.278141635753753 1354 41905287 SGTC_487 nimodipine 119 µM 0.587482874598683 0.251175431065574 no 844 0.278439724376835 1276 4497 L-type voltage-gated calcium channels inhibitor SGTC_2336 9001819 198.65 µM 0.587404600730189 0.251203759524152 no 845 0.278466002327393 1457 2989602 SGTC_2245 6637752 200 µM 0.58662099514833 0.251487450955369 no 846 0.278729139442609 1351 681890 SGTC_2805 7950783 58.44 µM 0.584767874512964 0.252159015616979 no 847 0.279351904114807 1396 1178958 YDL195W SEC31 SGTC_940 3232-1287 54.8 µM 0.584115551386234 0.252395640195953 no 848 0.279571286318166 1339 1585493 YIL048W NEO1 SGTC_653 0203-0016 55.2 µM 0.583534480635548 0.25260651710855 no 849 0.279766776108809 1399 295302 SGTC_288 1315-0019 35.1 µM 0.582873717243295 0.25284642807809 no 850 0.279989157473236 1385 6811474 SGTC_1907 st060210 83.7 µM 0.582710708332594 0.252905632038838 no 851 0.280044031654464 1426 688793 SGTC_2756 carbadox 75.1 µM 0.578484447531989 0.254443130460544 no 852 0.281468547260485 1362 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2741 miltefosine 3.04 µM 0.577981362409322 0.254626476694284 no 853 0.281638351153269 1332 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_254 nsc-64875 3.808 µM 0.576051406737753 0.255330478375458 no 854 0.282290217611819 1488 56993 SGTC_376 3970-0862 59.1 µM 0.575372225148305 0.255578469382067 no 855 0.282519792189709 1407 3135186 SGTC_218 alverine citrate 93.75 µM 0.57386411762652 0.256129577366174 no 856 0.283029878133531 1400 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3162 9099653 49.47 µM 0.573651828378035 0.256207203990636 no 857 0.283101716025787 1357 25237511 SGTC_734 2023-0417 80 µM 0.573237711390469 0.256358667133819 no 858 0.283241876852078 1399 3935732 SGTC_2532 xanthone 78.9 µM 0.572340520803914 0.256686974275566 no 859 0.283545651479429 1399 7020 An insecticide. SGTC_155 k072-0202 43.6 µM 0.572250353075385 0.256719981272462 no 860 0.283576189485825 1330 5857737 SGTC_1579 chlormadinone acetate 49.4 µM 0.572047478956828 0.256794253896355 no 861 0.283644904653466 1440 45114258 A steroidal progestin. SGTC_2478 5763493 32.33 µM 0.571815011930671 0.256879374292358 no 862 0.283723652992237 1376 1365576 YLR208W SEC13 SGTC_1617 st002906 78 µM 0.569640364058443 0.257676356417857 no 863 0.284460822836807 1377 5150859 SGTC_1245 0418-0076 17.2 µM 0.569637430496112 0.257677432399352 no 864 0.284461817883841 1413 6790114 SGTC_1123 mangostin 811.285 nM 0.56845400286263 0.25811168402497 no 865 0.284863365127515 1380 5281650 An antioxidant. SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.568105413010801 0.258239669279547 no 866 0.284981696220911 1364 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1830 st055982 50.3 µM 0.567317908960151 0.258528923549676 no 867 0.28524910585657 1376 455313 An antimicrobial agent. SGTC_2220 6782180 200 µM 0.567028679020948 0.258635201302574 no 868 0.285347348532317 1358 833803 SGTC_1725 st036284 20.55 µM 0.564481136774899 0.259572273675486 no 869 0.286213367077699 1514 707914 SGTC_266 formosanin C 406 nM 0.563388604460264 0.259974680517568 no 870 0.286585147593505 1395 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3111 9122088 49.47 µM 0.56315500360663 0.260060763256254 no 871 0.28666466991914 1323 16876704 SGTC_479 n-linoleoylglycine 10 µM 0.562613922452732 0.260260209998824 no 872 0.286848904763881 1386 6433346 An anti-infammatory. SGTC_2437 5741531 144.16 µM 0.562436982031669 0.260325448718605 no 873 0.286909164074615 1498 2262990 SGTC_3039 9090270 49.47 µM 0.561987294922886 0.260491288261086 no 874 0.287062337724414 1400 17173750 SGTC_549 1661-1316 519 µM 0.561679489870516 0.260604834653713 no 875 0.287167205441584 1444 2857282 SGTC_3119 9125183 49.47 µM 0.561078521971846 0.260826599476678 no 876 0.287372004599672 1301 22695334 SGTC_1854 st056233 32.9 µM 0.560818612829528 0.2609225393298 no 877 0.287460598404705 1385 5393174 SGTC_1802 st050112 57.9 µM 0.56016917169196 0.261162345823503 no 878 0.287682026289032 1364 4662563 SGTC_2017 5132927 60.65 µM 0.559421039676301 0.261438734305816 no 879 0.287937202830356 1355 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2235 salicylic acid 500 µM 0.556986893687154 0.262339038842347 no 880 0.288768191959812 1410 338 A COX inhibitor and kinase inhibitor. SGTC_2976 9009005 19.48 µM 0.556553511550525 0.262499497925537 no 881 0.288916261910748 1505 2993148 SGTC_1762 st045503 25.4615 µM 0.555669125425655 0.262827096352767 no 882 0.289218533315528 1402 4645554 SGTC_2489 cantharidin 73.42 µM 0.555531127461464 0.262878233052588 no 883 0.289265712587774 1369 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2080 5212524 12.4 µM 0.553818949835811 0.263513122609553 no 884 0.28985137907176 1427 260183 SGTC_2166 5933061 31.504 µM 0.553634654121084 0.263581507597853 no 885 0.28991445229928 1571 2877375 SGTC_3305 9127027 53.8275 µM 0.553521824820614 0.263623378641509 no 886 0.28995307009094 1398 41905295 SGTC_3095 9117207 49.47 µM 0.552357726258877 0.264055574577463 no 887 0.290351643832781 1392 17015229 SGTC_180 1486-1293 102.781 µM 0.552238473138228 0.264099870170784 no 888 0.290392489190361 1521 4140536 SGTC_478 N-arachidonylglycine 10 µM 0.550990167711844 0.264563770083224 no 889 0.290820207358933 1391 5283389 SGTC_1055 3448-0672 86 µM 0.550797960766165 0.26463523555692 no 890 0.290886091118091 1401 748378 SGTC_2524 avocatin b 10.57 µM 0.54962810036631 0.265070419150846 no 891 0.291287240524246 1397 6710748 SGTC_354 2783-3500 4.88 µM 0.549238137127871 0.265215564729674 no 892 0.291421017701647 1363 6740761 SGTC_135 0933-0004 26.348 µM 0.548130872987668 0.265627911879334 no 893 0.291801021634137 1372 21230617 YGL099W LSG1 SGTC_3128 9127691 49.47 µM 0.547539731810589 0.265848186957243 no 894 0.292003990899315 1419 41316314 SGTC_2186 6124449 200 µM 0.547177160207822 0.265983336660862 no 895 0.292128512949284 1426 3834182 YLR033W RSC58 SGTC_1019 4262-0212 3.4 µM 0.54703024388891 0.266038110087605 no 896 0.292178977110294 1450 4677213 SGTC_3205 9113483 49.47 µM 0.546950386424166 0.266067884990136 no 897 0.292206408984214 1512 17018033 SGTC_2027 5150920 200 µM 0.546939042693036 0.266072114643829 no 898 0.292210305771631 1437 786715 SGTC_446 go6976 132 µM 0.546491466868236 0.266239026126958 no 899 0.292364075873236 1426 3501 A protein kinase C inhibitor. SGTC_1416 3966-0321 25.3 µM 0.546158871479812 0.266363093036438 no 900 0.29247836741523 1399 582530 YLR208W SEC13 SGTC_800 3448-7362 155 µM 0.546149055337342 0.266366755162575 no 901 0.29248174090454 1482 15991913 SGTC_2476 5806916 10.51 µM 0.546122783659515 0.266376556510571 no 902 0.292490769715803 1409 2870194 SGTC_1994 st072947 40.9 µM 0.544668457505139 0.266919416055378 no 903 0.292990781247524 1442 5286565 YDL195W SEC31 SGTC_442 cape 100 µM 0.544477622185986 0.266990691033185 no 904 0.29305642171714 1485 5281787 SGTC_607 4491-0986 66.8 µM 0.542800687017749 0.267617421685016 no 905 0.293633520077621 1489 698981 YDR232W HEM1 SGTC_271 rotenone 740 µM 0.541851669709422 0.267972431703206 no 906 0.293960346638515 1448 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_176 1486-1328 72.834 µM 0.541767146348543 0.268004061843512 no 907 0.293989463303948 1408 22310231 SGTC_2268 7933382 153.85 µM 0.541234065040825 0.268203593624282 no 908 0.294173130235977 1414 935025 YOR257W CDC31 SGTC_3076 9116187 49.47 µM 0.541154241338925 0.268233477986373 no 909 0.294200637122368 1485 27241210 SGTC_3319 9138450 16.7555 µM 0.536995333151724 0.269792802023831 no 910 0.295635418843948 1419 2029690 SGTC_3073 9114972 49.47 µM 0.536093238919822 0.2701316276192 no 911 0.295947056309176 1467 41905075 SGTC_185 k048-0037 25.491 µM 0.535392187414011 0.270395088690228 no 912 0.296189345661807 1445 6827589 SGTC_1797 st048695 56.8 µM 0.533635101040053 0.271055980389714 no 913 0.296797009118697 1476 592262 YIL048W NEO1 SGTC_2959 9079155 11 µM 0.533385776949955 0.271149823722168 no 914 0.296883280539957 1427 16189457 SGTC_2618 avocadyne 43.43 µM 0.531680659934225 0.271792048282197 no 915 0.297473594531223 1435 3015189 SGTC_2122 5258151 111.688 µM 0.531130637227029 0.27199937318378 no 916 0.297664127460983 1396 2173356 SGTC_139 0099-0334 718.624 µM 0.530313551002626 0.272307509822427 no 917 0.297947276416382 1458 97690 SGTC_1974 st069448 26.9 µM 0.529427920821915 0.272641691265428 no 918 0.298254316837902 1482 6323587 YNR016C ACC1 SGTC_634 1611-4317 11.2 µM 0.529309427886128 0.272686418522858 no 919 0.298295408252736 1486 2843522 SGTC_282 k297-0036 65.7 µM 0.528708599439955 0.272913267888888 no 920 0.298503805402741 1455 5061378 SGTC_1133 3473-0247 50 µM 0.52851301699241 0.272987132371018 no 921 0.298571657397776 1389 711311 SGTC_2972 9093619 59.92 µM 0.528500067952453 0.272992023109217 no 922 0.298576149961548 1386 25236256 SGTC_1033 k072-0102 21.3 µM 0.528490591079158 0.272995602468218 no 923 0.298579437904908 1521 5965931 SGTC_2996 9066192 71.4286 µM 0.526837741979185 0.273620229467568 no 924 0.299153135519356 1375 6472854 SGTC_1569 carminic acid 40.6 µM 0.525196612210315 0.274241126475277 no 925 0.299723259882184 1470 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2002 4023503 131 µM 0.524577358701492 0.274475592489287 no 926 0.299938514805602 1523 4736863 YCR052W RSC6 SGTC_1496 4469-0713 57.4 µM 0.524451457067061 0.274523274327852 no 927 0.299982287259243 1484 746691 SGTC_165 k038-0023 64.381 µM 0.52351580509029 0.274877755197106 no 928 0.300307677630921 1405 46368543 SGTC_2746 daunorubicin 9.88 µM 0.523183210208179 0.275003816334029 no 929 0.300423382103367 1424 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_759 3486-0358 89.3 µM 0.522977907037702 0.275081645188141 no 930 0.300494813863995 1565 875103 SGTC_875 0709-0210 25.7 µM 0.522501392811846 0.275262329869601 no 931 0.300660638474514 1474 6251364 SGTC_2514 salinomycin 42.74 µM 0.521874369400019 0.275500173606601 no 932 0.300878902453426 1556 23682228 A polyether potassium ionophore. SGTC_1563 conessine 56.1 µM 0.52167740501975 0.275574907375989 no 933 0.300947479599317 1516 441082 An anti-amoebic, histamine inhibitor. SGTC_2084 5306078 60.6385 µM 0.519807144904765 0.276285032479294 no 934 0.301598999473393 1465 679340 SGTC_2986 9022445 71.43 µM 0.519597742859734 0.276364596873219 no 935 0.301671985807156 1542 6459286 SGTC_2757 clomiphene 4.22 µM 0.518459729806536 0.276797192683414 no 936 0.302068774983515 1579 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2766 oltipraz 83.91 µM 0.51813046548613 0.276922418610837 no 937 0.30218362273982 1524 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_350 k064-0020 19.8 µM 0.518042181799711 0.276955999410318 no 938 0.302214419518185 1537 2790705 SGTC_1198 1612-1005 86.7 µM 0.517760622983667 0.277063110317887 no 939 0.302312647576112 1509 6998509 SGTC_132 0417-1715 25.805 µM 0.51774986322519 0.277067203958934 no 940 0.302316401641398 1558 6769098 SGTC_3218 9131285 49.47 µM 0.517421060796347 0.277192313893597 no 941 0.302431130450115 1588 17156417 SGTC_3177 9107506 49.47 µM 0.516475401590889 0.277552292953053 no 942 0.302761207449543 1468 8897194 SGTC_1656 st012921 11 µM 0.515248437290969 0.278019695141957 no 943 0.303189712707967 1487 6732821 SGTC_1790 st045711 43.5 µM 0.512772704497423 0.278963973300663 no 944 0.304055162666336 1585 585119 SGTC_2304 7443016 91.4 µM 0.511199617392672 0.279564779592209 no 945 0.30460564328715 1436 939854 SGTC_867 0518-0118 155 µM 0.510422427942313 0.279861841816732 no 946 0.304877773762824 1487 6848158 SGTC_3214 9129694 49.47 µM 0.510262614629283 0.279922945635505 no 947 0.304933745286853 1543 17158655 SGTC_3050 9093513 49.47 µM 0.509561873102066 0.280190946992129 no 948 0.30517922033431 1438 25236664 SGTC_1063 disulfiram 1.84 µM 0.509530433886872 0.280202973957084 no 949 0.305190235784288 1454 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_386 1509-0011 3.07 µM 0.508695021124294 0.280522649860964 no 950 0.305483006420164 1457 3107280 SGTC_2482 5981709 142.65 µM 0.507781855859241 0.280872280036425 no 951 0.30580316779443 1504 877755 SGTC_1785 bathophenanthroline 24 µM 0.507307236087041 0.281054084294979 no 952 0.305969631072116 1424 72812 An iron chelator. SGTC_1701 st028638 40.4 µM 0.504313274911446 0.282202237058078 no 953 0.30702062519514 1552 3490878 SGTC_3166 9102297 49.47 µM 0.503895501957814 0.282362627921675 no 954 0.307167405795304 1416 25237072 SGTC_2309 7664088 163.95 µM 0.503155688354825 0.282646763764939 no 955 0.307427408154265 1517 704922 SGTC_2519 cryptotanshinone 88.04 µM 0.502943870793212 0.282728140582365 no 956 0.307501867797032 1533 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1822 st052468 42 µM 0.502458435333653 0.282914679338866 no 957 0.30767254150236 1435 2873678 SGTC_1756 st041558 35.5 µM 0.501526550763424 0.283272941060659 no 958 0.30800029839858 1655 3955792 SGTC_807 1315-0151 48 µM 0.501285605388234 0.283365607563998 no 959 0.308085067210083 1591 4011080 SGTC_1114 scopoletin 1.73284 µM 0.500800140838713 0.283552359169344 no 960 0.308255893252971 1558 5280460 A coumarin with genotoxic properties. SGTC_2041 5107442 45.335 µM 0.500681916630088 0.28359784734172 no 961 0.308297500467239 1553 793005 SGTC_196 k015-0023 18.111 µM 0.492950069007954 0.286580332363176 no 962 0.311023934060583 1484 5211998 SGTC_3284 9108171 64.8615 µM 0.492046527973111 0.28692983311357 no 963 0.311343225944383 1505 8687505 SGTC_1628 st004252 77.7 µM 0.49111848530388 0.287289021486121 no 964 0.311671323985862 1604 692968 SGTC_689 0833-0039 98 µM 0.489163121232032 0.288046518576412 no 965 0.312363108162385 1552 5374726 SGTC_149 3970-0822 46.1 µM 0.488611609335991 0.288260341508681 no 966 0.312558346184021 1543 3114250 YBL034C STU1 SGTC_603 3794-0023 45.9 µM 0.487853463312089 0.288554399281896 no 967 0.312826819614737 1578 3802260 SGTC_2014 4013930 200 µM 0.486980822082024 0.288893040516835 no 968 0.313135960841292 1466 64556 SGTC_2809 7964133 12.99 µM 0.486737080416572 0.28898766145235 no 969 0.31322233206505 1525 1253665 SGTC_1791 st048313 56.1 µM 0.486225974985151 0.289186120790904 no 970 0.313403478405022 1584 1204976 SGTC_2715 st079500 56.4 µM 0.486176209378335 0.289205447916328 no 971 0.313421118771662 1446 28246688 SGTC_951 1171-0579 82.7 µM 0.485642600315156 0.289412720139886 no 972 0.313610293478388 1428 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1721 st082152 9.2685 µM 0.485164845393487 0.28959835587241 no 973 0.313779708415902 1446 5296051 SGTC_876 0720-0963 56.8 µM 0.484977384543937 0.289671210645022 no 974 0.313846193956779 1626 765861 SGTC_450 aminopyrene 156 nM 0.484547646848124 0.289838256331654 no 975 0.313998629086308 1553 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1753 st043925 64 µM 0.484385020402081 0.289901483529436 no 976 0.31405632368047 1537 670181 SGTC_2111 5486399 200 µM 0.481771205138298 0.290918589685215 no 977 0.314984243415737 1488 689674 SGTC_1523 st012844 44.7 µM 0.480360077618561 0.291468389850559 no 978 0.315485688275419 1534 4274103 SGTC_46 0329-0187a 2.197 µM 0.480241009576721 0.291514803023675 no 979 0.315528014728973 1584 46494817 SGTC_2322 7413319 38.22 µM 0.479860169140253 0.291663279205601 no 980 0.315663412603613 1549 1840400 SGTC_2953 9074162 66.49 µM 0.479681690110471 0.291732873979443 no 981 0.315726874680139 1643 16451992 SGTC_1176 0848-0131 83.3 µM 0.479023457948266 0.291989606966558 no 982 0.315960970310112 1598 6769040 SGTC_1253 0550-0034 176 µM 0.4790031028434 0.291997547828054 no 983 0.31596821063688 1501 5969915 SGTC_1476 4112-3294 3.34 µM 0.478831032454071 0.292064679336797 no 984 0.316029419029865 1591 704369 SGTC_646 4092-0839 27.3 µM 0.478643915504528 0.292137689260561 no 985 0.316095985466839 1592 877796 SGTC_2040 5100729 123 µM 0.47712849157486 0.29272929518142 no 986 0.316635313661755 1545 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3144 9087057 49.47 µM 0.476484340251786 0.292980933635365 no 987 0.316864680571319 1612 17249618 SGTC_1100 amiodarone 5.07 µM 0.475734838673781 0.293273853556609 no 988 0.317131648811597 1562 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1021 4476-0760 85.3 µM 0.475534221330827 0.293352281774022 no 989 0.31720312373665 1479 746768 SGTC_1720 st037298 9.481 µM 0.475499736732337 0.293365763968115 no 990 0.31721541042062 1500 597396 SGTC_1866 st057638 64 µM 0.47537154918486 0.293415883043672 no 991 0.317261084746686 1520 688802 SGTC_1734 st037168 69.4 µM 0.474199655829851 0.293874256514004 no 992 0.317678769391803 1506 708907 SGTC_1464 k208-0027 110 µM 0.474064219007581 0.293927252513007 no 993 0.317727056576316 1601 X1464 SGTC_2048 5246248 200 µM 0.473882819819299 0.293998240363209 no 994 0.31779173554438 1547 677046 SGTC_717 1532-0246 73.2 µM 0.4736416559211 0.294092628507874 no 995 0.317877732587536 1486 9561992 SGTC_2254 7938975 95.19 µM 0.472964417311105 0.294357764998194 no 996 0.318119282766654 1616 2969277 SGTC_2328 6201408 200 µM 0.472883443490881 0.294389473344634 no 997 0.318148168818396 1493 2890418 SGTC_1036 k216-0215 33.5 µM 0.472154616295956 0.29467494400837 no 998 0.318408215456619 1492 622330 SGTC_2243 6634756 200 µM 0.472006254217538 0.294733070842763 no 999 0.318461162236677 1619 885676 SGTC_738 1315-0003 72.4 µM 0.471093226444445 0.295090902671349 no 1000 0.318787081000867 1591 6251474 SGTC_882 0843-0131 351 µM 0.470813055362771 0.295200746807737 no 1001 0.318887120335637 1526 5425421 SGTC_472 calcifediol 10 µM 0.470584564499377 0.295290343082561 no 1002 0.318968716234743 1541 5283731 A vitamin D metabolite. SGTC_1973 st070275 50.2 µM 0.469782151399608 0.295605085945692 no 1003 0.319255333803204 1507 17118334 SGTC_1665 st014639 11.4 µM 0.468538556711997 0.296093184745221 no 1004 0.319699752488955 1593 981133 YIL048W NEO1 SGTC_2074 5212007 75.395 µM 0.467382333045758 0.296547322776722 no 1005 0.320113180105195 1593 758611 SGTC_1827 berberine 7.24 µM 0.466876604732805 0.296746061482467 no 1006 0.320294082219907 1407 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1877 wortmannin 25 µM 0.465355754381474 0.297344085115856 no 1007 0.32083835695331 1586 312145 A covalent inhibitor of PI 3-kinase. SGTC_1840 st055363 71 µM 0.464565338503718 0.297655107053781 no 1008 0.321121379489033 1465 676033 SGTC_468 gf-109203x 121 µM 0.464409403667393 0.297716483617232 no 1009 0.321177227025302 1565 2396 A protein kinase C inhibitor. SGTC_1008 4106-0037 6 µM 0.463973451452084 0.297888106748976 no 1010 0.321333383298843 1525 2905394 SGTC_1922 5578187 25 µM 0.463743251400988 0.297978748760838 no 1011 0.321415852746904 1635 1350412 SGTC_1135 dihydrocapsaicin 536.708 nM 0.463229830442917 0.298180955190147 no 1012 0.321599818140397 1463 107982 A Capsaicinoid. SGTC_2876 9059903 25.97 µM 0.461879631565952 0.298713017463837 no 1013 0.32208382067542 1518 6916095 SGTC_1865 st057639 52.2 µM 0.461594095650195 0.298825591624193 no 1014 0.322186214747306 1530 688818 SGTC_3219 9131112 49.47 µM 0.460695325873446 0.299180062503657 no 1015 0.322508604469697 1510 17612988 YMR079W SEC14 SGTC_1491 4138-0063 26.5 µM 0.460253153846233 0.299354523227261 no 1016 0.322667261083598 1548 23883227 SGTC_976 1348-1067 47.6 µM 0.457543431123363 0.300424661307603 no 1017 0.323640246405057 1549 5310671 YGL099W LSG1 SGTC_1357 1503-1303 39.5 µM 0.455873268784332 0.301085110362051 no 1018 0.324240556427619 1534 292895 SGTC_1600 coumarin 106 71.1 µM 0.455832461825221 0.301101255253579 no 1019 0.32425522948796 1604 100336 A hepatotoxic, DNA x-linker. SGTC_1773 st048542 73.5835 µM 0.455788840846895 0.301118513916881 no 1020 0.324270914694048 1464 3237138 SGTC_2273 7815444 169.05 µM 0.455043214847588 0.301413590144627 no 1021 0.324539074663212 1665 2824616 SGTC_3251 9135047 49.47 µM 0.453950022071142 0.301846448604541 no 1022 0.32493239944428 1637 17682963 SGTC_200 k038-0079 37.545 µM 0.453109173634998 0.302179579247301 no 1023 0.325235064970051 1588 3436683 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.452437846243544 0.302445666786189 no 1024 0.325476793775692 1557 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_358 0075-0058 9.45 µM 0.451694686922962 0.302740348116171 no 1025 0.32574447316192 1770 1069125 SGTC_1529 apigenin 74 µM 0.44959565773175 0.303573359609299 no 1026 0.32650100983681 1638 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3049 9092223 49.47 µM 0.449238720359539 0.303715113964573 no 1027 0.326629729115128 1564 8623917 SGTC_2 0422-0095 29 µM 0.448878644110009 0.303858144819823 no 1028 0.32675960125483 1504 6790840 SGTC_2401 5128683 200 µM 0.448288157853202 0.304092765023255 no 1029 0.326972623006905 1477 708373 SGTC_1251 0490-5699 265 µM 0.447886762702908 0.304252299000101 no 1030 0.327117461116005 1671 3883818 SGTC_1238 0333-0287 48.8 µM 0.447638475945416 0.304350998903301 no 1031 0.327207065132103 1537 7226 SGTC_1801 st050089 28.441 µM 0.446479715996094 0.304811821985309 no 1032 0.32762538074713 1556 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2881 9058953 51.95 µM 0.445750022099946 0.305102170363102 no 1033 0.327888913414909 1475 17122249 SGTC_418 lividomycin a 100 µM 0.445548244506278 0.305182480212338 no 1034 0.32796180155656 1618 72394 An antibiotic. SGTC_1249 0481-0015 10.2 µM 0.444209955412312 0.305715372266311 no 1035 0.328445397621527 1508 4227577 SGTC_249 wiskostatin 11.211 µM 0.44403498041206 0.305785075850789 no 1036 0.328508646803262 1627 2775510 A n-wasp and actin depolymerizer. SGTC_1058 3448-5425 97.3 µM 0.443834428230602 0.305864977095202 no 1037 0.328581147554531 1513 7279705 SGTC_3246 9135460 32.98 µM 0.443762210281804 0.305893751441185 no 1038 0.328607256333216 1604 41446951 SGTC_1851 st056236 18.9 µM 0.441760002227975 0.306691982980328 no 1039 0.329331442511292 1666 5393171 SGTC_48 0382-0018 55 µM 0.441493596670612 0.306798261637922 no 1040 0.329427848097566 1697 762596 SGTC_2744 captopril 92.04 µM 0.441208224533903 0.306912124757319 no 1041 0.329531129799195 1663 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2650 prasterone 100 µM 0.440739639162009 0.307099130128608 no 1042 0.329700748123897 1558 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_389 tpck 16.7 µM 0.440210749269199 0.307310262416968 no 1043 0.329892237537778 1557 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_83 0170-0301 39.027 µM 0.439636023443436 0.307539764784179 no 1044 0.330100372820312 1578 3089716 SGTC_2729 fluphenazine 10.66 µM 0.439441103471243 0.307617618311168 no 1045 0.330170974466861 1497 3372 An atypical antipsychotic. SGTC_3282 9108498 15.4605 µM 0.436428342753346 0.308822053722934 no 1046 0.331262989441983 1544 16459645 SGTC_570 0987-0065 62.6 µM 0.435920424412989 0.309025311463721 no 1047 0.331447232913735 1573 3104428 SGTC_3348 9149464 3.537 µM 0.435917711710856 0.309026397184473 no 1048 0.331448217035135 1553 1951442 SGTC_2639 lactacystin 53 µM 0.434971037773049 0.309405391894709 no 1049 0.331791724986004 1660 3870 A proteasome inhibitor. SGTC_1805 st050013 60.3 µM 0.434910948586755 0.309429455056687 no 1050 0.331813533589106 1610 4037144 SGTC_2182 6325192 200 µM 0.434761131780438 0.309489453870468 no 1051 0.331867910168299 1556 736248 SGTC_1427 4048-4900 550 nM 0.434624085608045 0.309544342733082 no 1052 0.331917654699301 1662 24132586 SGTC_2474 5321570 43.32 µM 0.433994251678808 0.309796654432941 no 1053 0.332146307661834 1657 2841384 SGTC_375 3970-0961 9.27 µM 0.433195859440204 0.310116619470631 no 1054 0.332436243344041 1598 2898222 SGTC_740 k014-0057 261 µM 0.432907522695158 0.310232209160786 no 1055 0.332540977326093 1698 4012779 SGTC_2676 harmalol 100 µM 0.432266797763901 0.310489132876561 no 1056 0.332773757807062 1640 5459187 A monoamine oxidase inhibitor SGTC_2745 rifampicin 24.3 µM 0.431459266147572 0.310813075981265 no 1057 0.333067232324713 1692 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1368 1852-0141 284 µM 0.430625504979105 0.311147695057739 no 1058 0.333370346535185 1582 2838987 SGTC_1399 3562-5772 25 µM 0.430000319486126 0.311398707493914 no 1059 0.333597704394016 1544 23847490 SGTC_224 benfluorex 43.875 µM 0.429034500515927 0.31178665689659 no 1060 0.333949058740213 1673 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1980 st071811 45.7 µM 0.428660768877466 0.311936833221755 no 1061 0.334085057302027 1639 4974850 SGTC_1670 st016595 4.04 µM 0.425762484376763 0.31310250881694 no 1062 0.335140463066844 1582 597879 SGTC_1603 st002045 67.8 µM 0.425105708213946 0.313366921285416 no 1063 0.335379808451182 1651 5887985 SGTC_2231 micatex 6.853 µM 0.424844912274952 0.313471942125299 no 1064 0.335474867447802 1612 20737 An antifungal of unknown mechanism. SGTC_3277 9138724 49.47 µM 0.424326474243559 0.31368075868025 no 1065 0.335663867153429 1589 15943418 SGTC_335 4077-0256 27.6 µM 0.424175452319211 0.313741598548481 no 1066 0.335718930927757 1670 3121989 SGTC_3215 9129942 49.47 µM 0.421133177220384 0.314968269854615 no 1067 0.336828918077482 1680 17682944 SGTC_790 1575-0012 79.1 µM 0.421062723478102 0.314996701669054 no 1068 0.3368546403199 1635 378741 YLR208W SEC13 SGTC_1637 st007924 17.4 µM 0.420777431952257 0.31511184310751 no 1069 0.336958806359772 1567 683336 SGTC_2827 7993847 71.43 µM 0.419992781973545 0.315428614361273 no 1070 0.33724536332788 1623 2985692 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.4190651822174 0.315803270943959 no 1071 0.337584247880399 1572 6708630 An antioxidant. SGTC_181 1447-1644 8.07 µM 0.416914496728123 0.316672658479341 no 1072 0.338370474803751 1681 534600 SGTC_2819 7996655 46.38 µM 0.415956168405462 0.317060377412785 no 1073 0.338721038590603 1667 6456960 SGTC_1309 pyrazolanthrone 13.4 µM 0.415062410576581 0.317422153621531 no 1074 0.339048107966791 1696 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2730 imipramine 71.33 µM 0.414943288117424 0.317470385317057 no 1075 0.339091709827068 1641 3696 A tricyclic antidepressant. SGTC_53 0973-0023 39.979 µM 0.414879351625499 0.317496273950352 no 1076 0.339115113103756 1726 674768 SGTC_156 3474-0145 5.642 µM 0.414603361137974 0.317608035968309 no 1077 0.339216143625579 1746 2265471 SGTC_1531 st059297 52.4 µM 0.414487660593491 0.317654893711531 no 1078 0.339258501011857 1627 7566702 SGTC_1530 rhein 70.4 µM 0.413044921825772 0.318239435838088 no 1079 0.339786850847218 1606 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2191 5911152 200 µM 0.411968649899743 0.318675794801217 no 1080 0.340181200883048 1614 2875902 SGTC_2159 5658611 73.75 µM 0.411632626495428 0.318812082212947 no 1081 0.340304356950644 1685 793844 SGTC_847 0342-0274 5.54 µM 0.410771728959956 0.319161364612644 no 1082 0.340619962545526 1720 18097 SGTC_3101 9120531 49.47 µM 0.40998716386178 0.319479817382859 no 1083 0.340907681844827 1697 24824904 SGTC_957 1187-1561 14.1 µM 0.408781064810096 0.319969629287921 no 1084 0.341350168473423 1597 1538454 SGTC_1882 5615643 20 µM 0.407497393100349 0.320491289392028 no 1085 0.341821354213205 1580 2253075 SGTC_2069 5228469 200 µM 0.406849670378862 0.320754646518452 no 1086 0.342059201547563 1583 2835210 SGTC_1714 st033236 13.627 µM 0.405606924855718 0.321260186118367 no 1087 0.342515719963476 1714 2916566 SGTC_801 0866-0028 10.1 µM 0.405441143014696 0.321327650004005 no 1088 0.342576636782321 1636 6849771 SGTC_1920 st075728 45.7 µM 0.405074560810636 0.321476849273249 no 1089 0.342711352570955 1746 3400306 SGTC_2377 9073351 62.6 µM 0.404032647351114 0.321901066161724 no 1090 0.343094355940251 1581 7337946 YHR072W ERG7 SGTC_2378 9074213 121.43 µM 0.403136981906294 0.322265923563452 no 1091 0.343423728016729 1597 657714 SGTC_1335 1486-0900 202 µM 0.402977090408938 0.322331074838236 no 1092 0.34348253904673 1609 X1335 SGTC_1342 1486-1464 234 µM 0.401768943132526 0.322823537084588 no 1093 0.343927040214514 1608 3253938 SGTC_3338 9144300 39.5675 µM 0.401313149689804 0.323009407379861 no 1094 0.344094791692081 1676 4901274 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.400354429740219 0.323400512846783 no 1095 0.344447741754264 1629 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1398 3558-0053 112 µM 0.398792574498248 0.324038082561548 no 1096 0.345023024436284 1604 4532369 SGTC_97 0535-0701 19.132 µM 0.398665122155501 0.324090133090605 no 1097 0.345069985162094 1551 2832013 YGL099W LSG1 SGTC_2339 9000433 200 µM 0.397968770192588 0.324374578426172 no 1098 0.345326603132207 1555 2988954 SGTC_671 0560-0003 407 µM 0.397889126302793 0.324407117839092 no 1099 0.345355957843748 1684 3238678 SGTC_3108 9121785 49.47 µM 0.395943835945908 0.325202304046104 no 1100 0.346073230840057 1751 17140271 SGTC_2648 atorvastatin 78.68 µM 0.393126720239144 0.326355282394033 no 1101 0.347112944873272 1715 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1655 st012546 55.1 µM 0.392217741380821 0.326727660818142 no 1102 0.347448668248541 1636 720985 YLR208W SEC13 SGTC_665 3914-0008 307 µM 0.390970797359193 0.327238773195468 no 1103 0.347909410799993 1588 1069549 SGTC_2549 cedrol 20.94 µM 0.390946401681417 0.327248776024119 no 1104 0.347918427181856 1703 6708665 A sedative which affects the nervous system. SGTC_86 0417-1630 471.922 µM 0.390678259436009 0.327358729122528 no 1105 0.348017535356973 1660 3634867 SGTC_2426 5582046 32.21 µM 0.390252006011539 0.32753354734873 no 1106 0.348175104444485 1664 2251934 SGTC_474 dl-dihydrosphingosine 5 µM 0.38964564212278 0.327782298981081 no 1107 0.348399298432156 1694 3058739 A sphingolipid protein kinase C inhibitor. SGTC_698 k064-0052 127 µM 0.389097240155596 0.328007338444055 no 1108 0.34860210748934 1695 5088751 SGTC_65 0798-0905 34.986 µM 0.387287329680455 0.32875048700188 no 1109 0.349271752265952 1833 3602145 SGTC_3107 9121808 49.47 µM 0.387249830311731 0.328765891404086 no 1110 0.34928563154607 1724 662681 SGTC_2229 7354935 190 µM 0.387143868178073 0.328809421264624 no 1111 0.349324851379238 1686 318112 SGTC_2616 abietic acid 100 µM 0.386540277577152 0.329057424070961 no 1112 0.349548289433675 1772 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2004 4023728 41.89 µM 0.385685910729465 0.329408594257092 no 1113 0.349864649319822 1768 360084 YDR527W RBA50 SGTC_536 3852-0578 10.6 µM 0.384866682571194 0.329745462771178 no 1114 0.350168095770966 1747 2869208 SGTC_1486 3970-0793 4.53 µM 0.383626990454893 0.33025548969758 no 1115 0.350627466205273 1735 2844330 SGTC_1029 k015-0030 64.7 µM 0.382058510354942 0.330901236780632 no 1116 0.351208982756059 1694 2208316 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.381248453343598 0.331234936504629 no 1117 0.351509449290914 1760 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1066 ketoconazole 628 nM 0.380153810326664 0.331686083244612 no 1118 0.35191562194492 1733 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1516 st013856 110 µM 0.379979887380572 0.331757786440037 no 1119 0.351980172481088 1651 5281404 A mutagen and neurotoxin. SGTC_3262 9137218 49.47 µM 0.379921990164683 0.331781657086991 no 1120 0.352001661657966 1641 17650664 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.37980487157592 0.331829946410327 no 1121 0.352045132932042 1631 279621 SGTC_112 phenothiazine 287.218 µM 0.379503784443289 0.331954100874915 no 1122 0.352156897262185 1813 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1800 st050079 29.0735 µM 0.379250797562041 0.332058435279314 no 1123 0.352250816527599 1669 3645560 SGTC_1454 4239-0054 42.6 µM 0.378976518998398 0.332171565305164 no 1124 0.352352650333114 1754 1340767 SGTC_799 1310-0557 151 µM 0.378864637997788 0.332217716580127 no 1125 0.35239419241255 1674 5354492 SGTC_1162 k048-0130 20.1 µM 0.378787266099924 0.332249634226904 no 1126 0.352422922087345 1653 6797406 SGTC_32 0928-0142 34.1 µM 0.377904472975811 0.332613892325272 no 1127 0.352750779739254 1715 2244242 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.37580913299054 0.333479103955401 no 1128 0.353529398778604 1686 616764 SGTC_1140 3229-1848 2.98 µM 0.375685826672807 0.333530047491719 no 1129 0.353575237997365 1751 2849525 SGTC_467 ro 31-8220 72.8 µM 0.375623578012997 0.333555766454987 no 1130 0.353598379791321 1757 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1409 3909-8004 61.9 µM 0.375105016114289 0.333770048439118 no 1131 0.353791183319231 1679 2119279 SGTC_2759 disulfiram 3.38 µM 0.37464878304684 0.333958619527625 no 1132 0.353960843738599 1616 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_903 1134-0042 114 µM 0.373885966031297 0.334274002106611 no 1133 0.354244578990649 1634 701009 SGTC_802 4112-3352 742 µM 0.373113140888647 0.334593641839867 no 1134 0.354532119371071 1761 704594 SGTC_783 0848-0141 92.7 µM 0.372558066006742 0.334823294287804 no 1135 0.354738693905566 1643 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_679 0422-0091 41.4 µM 0.372372229454145 0.33490019469612 no 1136 0.354807863671614 1606 627384 YHR062C RPP1 SGTC_281 1672-3440 14.9 µM 0.371553489927316 0.335239076991802 no 1137 0.355112661668972 1715 6833000 SGTC_1089 terbinafine 2.25 µM 0.36822760626709 0.336617061333692 no 1138 0.356351763715726 1761 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2851 9015922 71.43 µM 0.36753068165354 0.336906091034723 no 1139 0.3566116050426 1761 2996893 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.365216884617147 0.337866362707417 no 1140 0.357474757721542 1649 91467 include heat shock SGTC_655 k060-0012 42 µM 0.364495562697741 0.338165941871729 no 1141 0.357743993351458 1654 5994525 SGTC_2682 pyrogallin 40.03 µM 0.363784434566078 0.338461387696797 no 1142 0.358009493421925 1723 822798 An ATP competetive kinase inhibitor. SGTC_205 1486-1330 71.903 µM 0.363578532141349 0.338546950648535 no 1143 0.358086380032363 1705 4118834 SGTC_2155 5570423 76 µM 0.363497242248867 0.338580733037077 no 1144 0.358116736307463 1675 797402 SGTC_3257 9139206 32.98 µM 0.362818159827117 0.338862996292523 no 1145 0.358370362677349 1749 4910041 SGTC_1414 3917-0015 5.4 µM 0.362486727650506 0.339000790242881 no 1146 0.358494169969179 1728 6618702 SGTC_602 3130-1533 38.1 µM 0.361751429305316 0.339306569688646 no 1147 0.358768895536505 1775 720941 SGTC_2998 9066762 71.4286 µM 0.360923261548306 0.33965109633566 no 1148 0.359078406910893 1787 4945196 SGTC_1855 st056195 39.6 µM 0.35933977439772 0.340310216853308 no 1149 0.359670461458656 1788 4028379 SGTC_754 3474-0146 171 µM 0.35786181374897 0.340925852910509 no 1150 0.360223364469689 1588 24762078 SGTC_1410 3909-8106 77.9 µM 0.357766122766612 0.340965727068233 no 1151 0.360259172426082 1757 1039210 SGTC_2852 9023854 51.95 µM 0.356211044968643 0.341613972263611 no 1152 0.360841260524762 1752 19798528 SGTC_1989 st071868 50.2 µM 0.355779529875077 0.341793935317494 no 1153 0.361002840080554 1813 16414057 SGTC_2743 auranofin 4.32 µM 0.354849737964203 0.342181826525184 no 1154 0.361351082205835 1744 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2221 6807166 181.081 µM 0.354547956366063 0.34230775980094 no 1155 0.361464135506881 1744 674925 SGTC_1232 0279-0259 161 µM 0.354486774638894 0.342333293036689 no 1156 0.361487056856057 1661 1560000 SGTC_3149 9097855 49.47 µM 0.352191226564763 0.343291823988078 no 1157 0.362347428083745 1831 25236625 YMR079W SEC14 SGTC_3170 9103054 49.47 µM 0.351984102884467 0.343378360439068 no 1158 0.362425092307266 1667 16432970 SGTC_2204 7233102 200 µM 0.351308231732775 0.343660797080184 no 1159 0.362678560005176 1748 2172480 SGTC_1160 4092-0570 10.5 µM 0.351109506050957 0.343743858241671 no 1160 0.362753098300237 1633 4994975 SGTC_2470 5664817 21.68 µM 0.350982691516504 0.343796866720619 no 1161 0.362800666784418 1703 2859561 SGTC_1668 st014914 51.6 µM 0.35016193855826 0.344140015695545 no 1162 0.363108584665893 1714 2839556 SGTC_3129 9127257 49.47 µM 0.349317189716807 0.344493331189135 no 1163 0.363425597390397 1584 837894 SGTC_939 1165-0479 45.3 µM 0.34864793477489 0.344773342882854 no 1164 0.363676818157474 1795 1377347 SGTC_1374 2889-5571 141 µM 0.346169351691057 0.345811104857075 no 1165 0.364607723126275 1682 2853281 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.345874748871386 0.345934529838188 no 1166 0.36471842313396 1757 1377 SGTC_2226 7298446 200 µM 0.342213529672228 0.34746977399971 no 1167 0.366095102022263 1808 3283010 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.341749236289949 0.347664643785221 no 1168 0.366269807656495 1848 6728940 SGTC_320 4092-0846 5.34 µM 0.341065279380985 0.347951782442533 no 1169 0.366527219397706 1775 1359356 SGTC_704 1310-0270 142 µM 0.340356072953848 0.34824961345065 no 1170 0.366794197382893 1660 5718033 SGTC_2960 9079389 5.97 µM 0.339270494516933 0.348705683015611 no 1171 0.367202983931987 1840 16457355 SGTC_1859 st055998 20 µM 0.338431711211514 0.349058219671977 no 1172 0.367518940196885 1858 676301 SGTC_1075 aripiprazole 15.2 µM 0.338193911557317 0.349158189464028 no 1173 0.367608531855122 1704 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3041 9091929 49.47 µM 0.337436646688286 0.349476609564921 no 1174 0.367893881413549 1768 25236887 SGTC_817 1391-0715 46 µM 0.334465455850327 0.350726978495895 no 1175 0.369014176828692 1678 1353946 SGTC_813 k007-0158 173 µM 0.33393633584777 0.350949818725986 no 1176 0.369213800028995 1809 6523916 SGTC_136 0097-0015 404.482 µM 0.332530096458803 0.351542309051486 no 1177 0.36974450885771 1827 4861337 SGTC_1710 st031758 61.5 µM 0.332335374541755 0.351624379640439 no 1178 0.369818015676746 1813 5394341 SGTC_1050 3232-1156 69.3 µM 0.331443634505609 0.352000314854676 no 1179 0.370154705050777 1693 700529 SGTC_138 0850-0259 40.9225 µM 0.331055418773918 0.35216402209682 no 1180 0.370301312636339 1742 6813004 SGTC_103 0844-0104 51.839 µM 0.330926134781804 0.352218546129986 no 1181 0.370350140224922 1811 5375804 SGTC_1526 st051518 75 µM 0.329357861980273 0.352880188735616 no 1182 0.370942606926928 1725 673993 SGTC_1587 estradiol valerate 56.1 µM 0.32860385614897 0.353198456768956 no 1183 0.371227566506645 1864 13791 A steroid. SGTC_1345 1488-0192 31.4 µM 0.327988603605286 0.353458232748967 no 1184 0.371460139719417 1843 658348 SGTC_545 4218-0007 221 µM 0.325691254430303 0.354428837243476 no 1185 0.372328980863477 1753 2840508 SGTC_111 0083-0039 52.457 µM 0.32432394055739 0.355006961739071 no 1186 0.372846398235802 1754 759313 SGTC_20 0481-0013 4.944 µM 0.324286335651839 0.355022866483369 no 1187 0.372860631888429 1701 182045 SGTC_552 k242-0005 476 µM 0.323112523026728 0.355519449598738 no 1188 0.373305013260097 1741 4088318 SGTC_2962 9082311 13.18 µM 0.322635576834093 0.355721292519488 no 1189 0.373485623495367 1683 16459453 SGTC_512 prima-1 270 µM 0.322172941951986 0.35591711757247 no 1190 0.373660840872299 1819 322968 A re-activator of the apoptotic function of mutant p53. SGTC_344 k064-0035 6.43 µM 0.320439254322136 0.356651294302785 no 1191 0.37431768618574 1680 5088750 SGTC_600 1495-0418 41.6 µM 0.319516548327254 0.357042255876398 no 1192 0.37466742238642 1753 5377768 SGTC_567 1080-0542 68.4 µM 0.318882262339922 0.357311097562602 no 1193 0.374907897656802 1855 5950415 SGTC_114 0364-0001 490.298 µM 0.318231410650687 0.357587034252766 no 1194 0.375154704006111 1690 4003655 SGTC_1939 st074455 53.6 µM 0.315748934642535 0.358640193434124 no 1195 0.376096540402406 1889 1644229 SGTC_369 0957-0393 4.5 µM 0.312294460100816 0.360107499615805 no 1196 0.377408374935778 1692 6997992 SGTC_2046 4110841 106 µM 0.309674576129172 0.36122168632657 no 1197 0.378404219149427 1884 44119630 YMR134W ERG29 SGTC_287 k060-0039 29.6 µM 0.309043123895811 0.361490407503818 no 1198 0.378644361602491 1872 5861974 SGTC_429 1112-0049 25.5 µM 0.30868109237699 0.361644504676889 no 1199 0.378782064002871 1708 2836170 SGTC_1352 1496-0991 99 µM 0.308096599822235 0.36189333879478 no 1200 0.379004414211833 1740 3000039 SGTC_1687 st020778 55.3625 µM 0.308061179119378 0.361908420213317 no 1201 0.379017890094806 1801 4259299 SGTC_2533 agelasine 13.65 µM 0.307842727549227 0.362001437210286 no 1202 0.379101003716296 1933 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1923 st058458 19.1 µM 0.307651328838588 0.362082941760305 no 1203 0.379173829210664 1884 3534982 SGTC_2038 4100038 30.985 µM 0.306637298783795 0.362514856994441 no 1204 0.379559730047389 1788 3596803 SGTC_2877 9040724 71.43 µM 0.305904650185452 0.36282702976842 no 1205 0.379838622623711 1894 6463895 SGTC_435 c-PAF 6.7 µM 0.30567403692338 0.36292531018951 no 1206 0.379926421615787 1900 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_50 0929-0078 56.389 µM 0.305616351807446 0.362949895259102 no 1207 0.379948384438745 1830 1377751 SGTC_1222 0366-0074 1.18 µM 0.3055761745133 0.362967018927951 no 1208 0.37996368162555 1887 286520 SGTC_385 1494-0393 12.4 µM 0.304391333738271 0.363472124235597 no 1209 0.380414884714428 1811 3090647 SGTC_304 1310-0298 97 µM 0.303682165987569 0.363774560700238 no 1210 0.380685023102344 1781 1550234 SGTC_1876 myriocin 605 nM 0.303323705572902 0.363927464460696 no 1211 0.380821591105273 1888 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_623 k072-0108 16.9 µM 0.303087243563749 0.364028340823512 no 1212 0.380911687688508 1794 5382803 SGTC_81 0411-0046 9.971 µM 0.302505206826701 0.36427668193407 no 1213 0.38113348240305 1776 12925265 SGTC_1502 4534-4282 27.7 µM 0.301658011377345 0.364638261735756 no 1214 0.381456390002738 1792 3278949 SGTC_2021 4019055 173 µM 0.301402952213168 0.364747143624218 no 1215 0.381553621692358 1812 44827708 YER133W GLC7 SGTC_2010 4012422 159 µM 0.300736159435076 0.365031841484561 no 1216 0.381807846598211 1816 952393 SGTC_1987 st072290 61.9 µM 0.30047839013744 0.365141920169931 no 1217 0.381906138740421 1786 54697379 SGTC_1512 0259-0544 12.2 µM 0.300332916282732 0.365204048730356 no 1218 0.381961613939947 1820 18476 SGTC_2119 5528445 120.635 µM 0.300070845429363 0.365315982132877 no 1219 0.38206155851466 1880 791935 SGTC_978 1416-0512 87.4 µM 0.300044392654436 0.365327281047579 no 1220 0.382071647106295 1798 6814003 SGTC_920 mycophenolic acid 780.421 nM 0.299210999789564 0.365683312387881 no 1221 0.382389528462594 1736 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2699 st077704 54.6 µM 0.298963371895901 0.365789123096667 no 1222 0.382483996550441 1782 645852 SGTC_2531 methyl deoxycholate 70.07 µM 0.298200259416654 0.366115263119757 no 1223 0.382775161904236 1733 16667744 Haematoxylin. SGTC_2085 5307070 144.047 µM 0.297329465869696 0.366487542206801 no 1224 0.383107493881271 1738 2840351 SGTC_1499 4480-0877 67.3 µM 0.296795391067127 0.366715930483093 no 1225 0.383311362206652 1835 2861909 SGTC_2115 tiliquinol 12.7705 µM 0.294800361877357 0.367569488634611 no 1226 0.384073194987794 1821 71208 A bioactive hydroxyquinoline. SGTC_1281 0884-0031 11.8 µM 0.293497319744805 0.368127339050709 no 1227 0.384571023937497 1748 1548255 SGTC_2896 9052656 71.43 µM 0.292658172059788 0.368486737157623 no 1228 0.384891722259192 1821 6469436 SGTC_1625 st003711 30.1 µM 0.292578344267039 0.368520932559257 no 1229 0.384922234271979 1863 24207034 YER133W GLC7 SGTC_1846 st056244 14.8 µM 0.291921870414296 0.368802182196362 no 1230 0.385173180642348 1838 5393182 SGTC_448 monastrol 171 µM 0.291118379370421 0.36914651327282 no 1231 0.385480391851674 1849 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2399 5884133 200 µM 0.291060318992708 0.36917139875762 no 1232 0.385502593764005 1738 722445 SGTC_2825 7998094 58.44 µM 0.290886285329039 0.369245995289208 no 1233 0.385569145357189 1792 2987815 SGTC_3315 9136395 68.55 µM 0.290704317442115 0.369323997954619 no 1234 0.385638734651485 1942 16876844 SGTC_1692 fluoroquinolonic acid 71 µM 0.290055338571001 0.369602234136644 no 1235 0.385886951161258 1834 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3151 9099821 49.47 µM 0.289240031854127 0.369951876702423 no 1236 0.3861988496982 1750 17174189 SGTC_503 tyrphostin 8 294 µM 0.289172766679003 0.36998072803613 no 1237 0.386224585521946 1902 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2789 5281112 71.43 µM 0.28909986099119 0.370011999521116 no 1238 0.386252479985235 1724 765948 SGTC_482 fipronil 114 µM 0.287931254913478 0.370513367664664 no 1239 0.386699680794736 1832 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1895 st058434 18.3 µM 0.28667165955594 0.371054019391217 no 1240 0.387181869791198 1931 5393175 SGTC_933 2914-0560 114 µM 0.286526086782291 0.371116519519307 no 1241 0.387237608125209 1962 463887 SGTC_44 0929-0055 61.211 µM 0.285882168094831 0.371393019941756 no 1242 0.387484185911334 1760 1379590 SGTC_1910 st062352 60.4 µM 0.285247121249174 0.371665775790548 no 1243 0.387727410837447 1725 2245730 SGTC_609 0986-0026 86.3 µM 0.284838601105046 0.371841271338031 no 1244 0.387883898624598 1855 2848610 SGTC_100 0086-0128 49.5915 µM 0.284300017179406 0.372072681484624 no 1245 0.388090236489277 1703 93297 SGTC_3160 9100216 49.47 µM 0.283817548687679 0.372280020092139 no 1246 0.388275102700028 1906 17191039 SGTC_2929 9013348 24.6 µM 0.283573219687623 0.372385033480419 no 1247 0.388368731273305 1804 2995952 SGTC_230 MPP+ 141.667 µM 0.282445977202791 0.37286964868897 no 1248 0.388800782366333 1747 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3252 9135871 49.47 µM 0.281364728796621 0.373334679620019 no 1249 0.389215334064976 1870 17682838 SGTC_850 0388-0143 75.9 µM 0.279803508808882 0.374006465577625 no 1250 0.389814129774502 1804 67273 SGTC_1975 st070967 30.8 µM 0.279506564528767 0.374134282765306 no 1251 0.389928050464647 1940 261391 SGTC_2507 purpurin 79.67 µM 0.279339690124108 0.374206118534733 no 1252 0.389992074866219 1707 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_527 4476-4215 268 µM 0.278413823345353 0.374604763150716 no 1253 0.390347354673305 1825 4418754 SGTC_3124 9127567 49.47 µM 0.276093545110053 0.375604378810849 no 1254 0.391238109161807 1918 17592030 SGTC_986 1493-0483 84 µM 0.275903053431324 0.375686483101079 no 1255 0.391311264305876 1936 40079 SGTC_639 0833-0042 114 µM 0.274836557396961 0.376146260088098 no 1256 0.391720905228575 1784 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2179 6298986 200 µM 0.274549448406505 0.37627006568073 no 1257 0.391831204270711 1957 738374 SGTC_98 0074-0023 107.663 µM 0.272440486786421 0.377179870247478 no 1258 0.392641672813924 1774 3563821 SGTC_1296 1068-0102 11.9 µM 0.272058528232404 0.377344720013945 no 1259 0.392788508425052 1907 767053 SGTC_1484 3473-2379 286 µM 0.271715389277598 0.377492834662728 no 1260 0.392920433702751 1932 671917 SGTC_347 4534-1311 26.2 µM 0.270633143320241 0.377960100034368 no 1261 0.393336601039483 1797 2862016 SGTC_2421 5690543 90.72 µM 0.270426014162257 0.378049549518039 no 1262 0.393416264489728 1841 3397993 SGTC_1395 3486-0190 4.35 µM 0.26959418133305 0.378408845370265 no 1263 0.393736238638621 1959 6748079 SGTC_1157 4092-0394 27.6 µM 0.269551403132411 0.378427325522081 no 1264 0.393752695711772 1911 3659885 SGTC_617 3770-0098 35 µM 0.268912509117923 0.37870336034183 no 1265 0.393998505276008 1840 5962639 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.268117999026624 0.379046715574187 no 1266 0.394304245838975 1964 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2134 5324836 1.464 µM 0.266485252880263 0.379752622019674 no 1267 0.394932757708041 1849 699272 SGTC_1751 st044839 27.194 µM 0.266081539500302 0.379927226603818 no 1268 0.395088206009149 1934 5291326 SGTC_934 2950-0684 338 µM 0.264371192086176 0.380667216846508 no 1269 0.3957469537273 1954 1121253 SGTC_1132 3456-3614 2.5 µM 0.263655255273988 0.380977100282985 no 1270 0.396022788453357 1998 3125502 SGTC_1434 4073-0095 163 µM 0.261631526244739 0.381853456005086 no 1271 0.396802767982915 1926 24133745 SGTC_2823 7987624 58.44 µM 0.260691002867731 0.382260946775589 no 1272 0.397165402444406 1860 2239440 SGTC_2890 9046729 58.44 µM 0.260138314162887 0.382500465331402 no 1273 0.397378542285245 1778 903329 SGTC_1038 k292-0204 154 µM 0.259919933687413 0.382595117215777 no 1274 0.397462767364827 1793 4454212 SGTC_3002 9075603 71.4286 µM 0.259902480052014 0.382602682386566 no 1275 0.397469499097114 1921 20105405 SGTC_1386 3228-0095 33.8 µM 0.25976643316301 0.382661652608196 no 1276 0.397521972377345 1928 870181 SGTC_334 1502-1024 68.5 µM 0.259697197626177 0.382691664151299 no 1277 0.397548677233505 1873 3296216 SGTC_702 1488-0190 94 µM 0.25867853978068 0.383133303325053 no 1278 0.397941639444838 1984 949357 SGTC_117 lucigenin 22.078 µM 0.25807971947833 0.383392992856799 no 1279 0.39817269152089 1745 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_284 0988-0104 32.6 µM 0.25717762974002 0.38378429969635 no 1280 0.398520826115601 1921 4666532 SGTC_1479 0549-0158 134 µM 0.256206440310593 0.384205712971279 no 1281 0.398895717958665 1837 5440202 SGTC_1507 4075-3230 155 µM 0.25594603113095 0.384318731616096 no 1282 0.398996255188669 1982 659771 SGTC_501 nsc-95397 161 µM 0.254056575586057 0.385139057034869 no 1283 0.399725925271331 1942 262093 SGTC_1792 st045773 43.6 µM 0.253159454281802 0.38552873122871 no 1284 0.400072498456521 1836 2919270 SGTC_1940 st075990 51.1 µM 0.252377801348733 0.385868344743202 no 1285 0.400374528434048 1918 1084979 SGTC_2313 7726885 200 µM 0.25226246831992 0.385918462191037 no 1286 0.400419098059668 1852 726423 SGTC_2310 7668677 200 µM 0.249789613062732 0.386993487101883 no 1287 0.401375026376717 1895 2197143 SGTC_513 4245-1575 41.7 µM 0.248562065049712 0.387527462041671 no 1288 0.401849777673836 1947 719745 SGTC_2814 7977482 42.97 µM 0.247093056657212 0.38816675025945 no 1289 0.402418103573771 1958 6456762 SGTC_1020 4335-0961 93.3 µM 0.245907612863201 0.388682856955843 no 1290 0.40287687527228 1783 669075 SGTC_226 1,3-diallylurea 8.28947 mM 0.245608800119849 0.388812982120229 no 1291 0.402992538182706 1906 74537 YKL182W FAS1 SGTC_2369 9071472 200 µM 0.245457990062813 0.388878660708765 no 1292 0.403050916193208 1901 17296037 SGTC_2980 9014342 25.29 µM 0.244510417858458 0.389291406083409 no 1293 0.403417767255442 1878 2996599 SGTC_1167 k781-0610 148 µM 0.244285683307062 0.389389314750574 no 1294 0.403504785360003 1864 4525169 SGTC_714 4296-0578 26.1 µM 0.243986564773318 0.389519640704489 no 1295 0.403620612646088 2003 1589775 SGTC_2125 5246583 200 µM 0.243283235862526 0.389826130066036 no 1296 0.403892995087918 2031 835267 SGTC_10 0279-0212 42.575 µM 0.241865367615353 0.390444202066017 no 1297 0.404442243066128 1904 39851 YBR002C RER2 SGTC_724 3910-0327 137 µM 0.241590841586202 0.390563904513029 no 1298 0.404548609632944 1831 2885483 SGTC_25 0118-0223 35.662 µM 0.240186135068122 0.391176565211616 no 1299 0.405092980869071 1961 5333628 SGTC_153 4077-0274 519.67 µM 0.239802997438713 0.3913437170809 no 1300 0.405241491572924 2005 3121976 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.239320608624541 0.391554197908108 no 1301 0.405428493137997 1863 688803 SGTC_1618 st003135 44.5 µM 0.239182719316643 0.391614369021135 no 1302 0.40548195090997 1978 1270615 SGTC_3083 9117465 49.47 µM 0.239112854376844 0.391644857155051 no 1303 0.405509037251045 1807 16420915 SGTC_3233 9132340 49.47 µM 0.239096904189596 0.391651817698725 no 1304 0.405515221134495 1846 17682950 SGTC_1845 st056753 3.01 µM 0.238598584649641 0.391869298117581 no 1305 0.405708431360939 1794 5375839 SGTC_1189 1431-2119 7.28 µM 0.238565784947994 0.391883613999855 no 1306 0.405721149384387 1900 3107275 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.236599761316252 0.392741978826644 no 1307 0.406483652693765 1928 368090 SGTC_2698 st077697 67.5 µM 0.235935974833465 0.393031905699646 no 1308 0.406741176130501 1792 3154499 SGTC_1693 xanthone 101.9 µM 0.23591835417199 0.393039602814027 no 1309 0.40674801281447 1947 7020 An insecticide. SGTC_1142 3253-1408 9.78 µM 0.235500289671572 0.393222235361997 no 1310 0.406910227024438 2014 256655 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.235104653181463 0.393395091821164 no 1311 0.40706375359797 1949 16623 A steroid. SGTC_902 1120-0002 2.07 µM 0.234861606305884 0.393501291190882 no 1312 0.40715807491855 1852 3280475 SGTC_1365 1672-3266 55.4 µM 0.234428873185537 0.393690393601953 no 1313 0.407326022758196 2008 6415873 SGTC_913 3487-1245 167 µM 0.231104366932379 0.395144020914469 no 1314 0.408616861312541 1835 4016153 SGTC_1220 1838-0075 193 µM 0.230993336871427 0.395192593686948 no 1315 0.408659989236041 1938 5529645 SGTC_462 ag-879 158 µM 0.228849319535187 0.396130864171693 no 1316 0.40949301617797 2001 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3347 9188721 44.724 µM 0.227607091024197 0.396674767283453 no 1317 0.409975853399256 1945 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2390 9097792 176.6 µM 0.227313450699363 0.396803365555428 no 1318 0.410090007353078 1825 4497149 SGTC_3249 9135183 49.47 µM 0.226911605209495 0.39697936991109 no 1319 0.410246238882732 1944 4902779 SGTC_824 1304-0008 100 µM 0.226843544079889 0.397009182092799 no 1320 0.410272701445695 1900 768245 SGTC_3157 9099274 49.47 µM 0.226474015791608 0.397171053622094 no 1321 0.41041638332092 2031 17217662 SGTC_2126 5251174 33.877 µM 0.225921051644212 0.397413312141741 no 1322 0.410631412118003 2046 790722 SGTC_927 2425-1185 123 µM 0.225654317431135 0.397530184932796 no 1323 0.410735145516384 1853 730375 SGTC_2739 tacrine 100.86 µM 0.225629801960523 0.397540927141704 no 1324 0.410744679938867 1926 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1572 epiandrosterone 68.9 µM 0.225321945516214 0.397675830541419 no 1325 0.410864414267772 1931 441302 A steroid. SGTC_459 nigericin 15.3 µM 0.22450587558566 0.398033493430757 no 1326 0.411181847770881 1929 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2603 homopterocarpin 100 µM 0.224149761106381 0.39818959631151 no 1327 0.411320386819712 1887 101795 A weak amylase inhibitor. SGTC_1559 coumarin 343 70.1 µM 0.223862179447024 0.398315669706771 no 1328 0.411432272649962 1984 108770 A hepatotoxic, DNA x-linker. SGTC_366 0181-0206 4.31 µM 0.22368585991688 0.39839297196481 no 1329 0.411500874665875 2042 274874 SGTC_796 1234-0020 70.7 µM 0.221674864217854 0.399274916920323 no 1330 0.412283499377715 1927 46495034 SGTC_2349 9023730 187.07 µM 0.221636623946163 0.399291692622232 no 1331 0.412298384839617 2006 4126287 SGTC_399 oxolinic acid 75 µM 0.22120226432375 0.399482255766954 no 1332 0.412467473126862 1905 4628 A DNA gyrase inhibitor. SGTC_2666 tannic acid 100 µM 0.221070413533447 0.399540106356754 no 1333 0.412518803453121 1949 16134267 A thiamine antagonist. SGTC_291 SEC14.278 35.5 µM 0.220635298311843 0.39973103228682 no 1334 0.412688207105145 2007 1068044 SGTC_533 1222-0222 6.71 µM 0.219995044274253 0.400012015475444 no 1335 0.412937507131071 2009 3982874 SGTC_821 1114-0266 29.2 µM 0.218168805947277 0.400813766134089 no 1336 0.413648794455143 1902 3123235 SGTC_491 tetrandrine 80.3 µM 0.217731546077504 0.401005793033493 no 1337 0.413819141535627 1999 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2164 5685496 200 µM 0.217116526507496 0.401275925295832 no 1338 0.414058767430169 2008 759046 SGTC_361 000s-0510 1.45 µM 0.217018411449189 0.40131902429736 no 1339 0.414096998295324 1904 660 SGTC_1190 1486-1332 13 µM 0.216995449345485 0.401329111034022 no 1340 0.414105945674455 1989 4150046 SGTC_1265 0819-1001 68.8 µM 0.216769691962069 0.401428284684675 no 1341 0.414193916333415 1971 3106768 SGTC_2409 alverine citrate 63.97 µM 0.216138601227334 0.401705552128992 no 1342 0.414439855668343 1977 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_268 camptothecin 39.6153 µM 0.215967984146986 0.401780520633436 no 1343 0.41450635179514 1954 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2263 7948595 193.29 µM 0.21433381763288 0.402498749984685 no 1344 0.415143374043436 1882 2971371 SGTC_561 1550-0330 72.9 µM 0.213984553206848 0.402652297299871 no 1345 0.415279551476001 1886 6812934 SGTC_1834 st055981 52.8 µM 0.213876069270933 0.402699993211168 no 1346 0.415321851196702 2031 471719 YDL150W RPC53 SGTC_537 1334-0398 209 µM 0.213062240713757 0.403057846189688 no 1347 0.415639207975604 2050 5846986 SGTC_1899 st063254 59.6 µM 0.212554192961012 0.403281283820928 no 1348 0.4158373518158 1846 3093813 SGTC_2000 st075254 36.4 µM 0.211932806862392 0.403554610187527 no 1349 0.416079727860895 1926 17234175 SGTC_2997 9067075 71.4286 µM 0.211708580592347 0.403653251183822 no 1350 0.416167196746566 1959 27209819 SGTC_3225 9130819 49.47 µM 0.211302795114725 0.403831778778417 no 1351 0.416325500989866 2003 4547121 SGTC_715 0868-0130 184 µM 0.211291665183759 0.403836675736385 no 1352 0.416329843168319 2071 2876258 SGTC_3173 9105693 49.47 µM 0.211138070209661 0.403904256142993 no 1353 0.41638976702525 1989 17096658 SGTC_3264 9137442 49.47 µM 0.210625116611912 0.404129971886367 no 1354 0.416589905864398 2037 17015726 SGTC_2460 5552655 174.22 µM 0.209646389005609 0.404560731365988 no 1355 0.416971835456783 1895 5401989 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.209564979697628 0.404596566606949 no 1356 0.417003607406311 1893 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2297 7971671 152.32 µM 0.209136181305697 0.404785330875334 no 1357 0.417170965281757 2012 909016 SGTC_2380 9035439 200 µM 0.208894124934776 0.404891897951526 no 1358 0.417265445306527 2005 6462575 SGTC_610 4215-0184 155 µM 0.20775339501662 0.405394207412973 no 1359 0.417710761971612 1966 5605015 SGTC_265 mycophenolic acid 32.932 µM 0.205411284750678 0.406426020833545 no 1360 0.41862540215105 2033 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_167 3672-0051 66.205 µM 0.205170747763263 0.406532026000799 no 1361 0.418719361584995 1940 3237971 SGTC_1311 1190-0148 100 µM 0.204059611028002 0.407021795139818 no 1362 0.419153457966999 2018 1961333 SGTC_1754 st042065 16.137 µM 0.203568716523611 0.407238218994573 no 1363 0.419345270901292 1974 1126236 YIL048W NEO1 SGTC_2773 thioridazine 9.09 µM 0.203202422143514 0.407399728037209 no 1364 0.419488409866614 2068 5452 An antipsychotic. SGTC_672 1441-0018 53.7 µM 0.202664649488601 0.407636874979025 no 1365 0.419698577683918 1912 251141 SGTC_896 0964-0007 44.5 µM 0.202651535368346 0.407642658465856 no 1366 0.419703703121213 2071 6756758 SGTC_3047 9092122 49.47 µM 0.200297131641471 0.408681304228179 no 1367 0.420624102857399 1927 17173831 SGTC_2598 perillyl alcohol 100 µM 0.199768391325851 0.408914646638364 no 1368 0.420830861537661 1993 10819 An apoptosis inducer. SGTC_336 4111-0029 111 µM 0.199386424572957 0.409083235382738 no 1369 0.420980239456163 1932 3131175 SGTC_3318 9139014 38.6185 µM 0.199122466639929 0.409199748379449 no 1370 0.421083473640608 1924 16643984 SGTC_2834 9001755 58.44 µM 0.198973885788343 0.40926533660288 no 1371 0.421141586132233 1912 2989575 SGTC_3015 9080845 49.47 µM 0.198422531180133 0.409508743916064 no 1372 0.421357245279594 2044 5296973 SGTC_1888 azatryptophan 97.5 µM 0.198063782974609 0.409667139743631 no 1373 0.421497580227752 1947 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2982 9019404 25.97 µM 0.196663795740616 0.410285408072579 no 1374 0.422045321778306 1756 22333232 SGTC_1166 k206-0078 225 µM 0.196284017435607 0.410453165911995 no 1375 0.422193935153703 1937 5404595 SGTC_408 cantharidin 100 µM 0.195682187288614 0.410719043303126 no 1376 0.422429463676427 1977 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1143 3454-2408 5.08 µM 0.195153844726337 0.410952489067983 no 1377 0.422636255420723 2011 X1143 SGTC_1874 staurosporine 7.6 µM 0.194971593551061 0.411033023244014 no 1378 0.422707592950469 2026 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1475 4092-1048 11.7 µM 0.19380250861972 0.411549714116916 no 1379 0.423165261330599 1977 2881759 SGTC_283 0987-0079 11.7 µM 0.192089774526438 0.412306953958832 no 1380 0.423835942254043 2062 411556 SGTC_1035 k081-0041 55.2 µM 0.191698534680476 0.412479976175735 no 1381 0.423989176928469 2086 731709 SGTC_3179 9107801 49.47 µM 0.191179725134749 0.412709441144074 no 1382 0.424192393819553 1965 4818259 SGTC_2445 5742597 35.57 µM 0.190940594383514 0.412815216653368 no 1383 0.424286067752238 1935 1774255 SGTC_1139 k015-0024 46.9 µM 0.190562720005922 0.412982376000573 no 1384 0.424434100004346 2084 2766652 SGTC_1477 0139-0234 16 µM 0.189887308721121 0.413281195295763 no 1385 0.424698718853768 2051 620880 SGTC_2206 7254556 146.969 µM 0.189869954845656 0.413288873758634 no 1386 0.424705518362543 2067 4398905 SGTC_1709 st033179 39.1045 µM 0.18884498920948 0.413742442748857 no 1387 0.425107154948137 2020 573381 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.186301228847984 0.414868606644947 no 1388 0.426104271926617 2088 688662 SGTC_1749 st037932 54.2 µM 0.186236351583062 0.414897338053337 no 1389 0.426129709076225 1955 594497 SGTC_3084 9116877 49.47 µM 0.185812950313263 0.415084855817229 no 1390 0.426295724256556 2083 27241325 SGTC_1903 st060211 78.3 µM 0.184196325051615 0.41580101132128 no 1391 0.426929721170754 2076 688960 SGTC_2902 5787006 60.46 µM 0.182722444946229 0.416454175397048 no 1392 0.427507901863004 1953 591003 SGTC_611 3453-1652 23.7 µM 0.180392687020351 0.417487099920472 no 1393 0.428422147532093 2085 1560575 SGTC_227 fluconazole 33.516 µM 0.178908020356025 0.418145641307861 no 1394 0.429004962531447 1955 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2337 9009472 200 µM 0.178265891339116 0.418430536416052 no 1395 0.429257082248956 2093 5742383 SGTC_3116 9124943 49.47 µM 0.17821796476915 0.418451801844372 no 1396 0.429275900861734 1881 41905195 YPL160W CDC60 SGTC_1872 amphotericin b 148 nM 0.176789929970019 0.419085542167352 no 1397 0.429836699591444 2066 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_874 0599-0792 117 µM 0.175805866296055 0.419522377114803 no 1398 0.430223230392663 2127 765305 SGTC_2947 9072639 7.68 µM 0.173893625800637 0.420371521533558 no 1399 0.430974531091894 1964 16488146 SGTC_774 k060-0086 136 µM 0.173726454362226 0.420445772915308 no 1400 0.431040223040085 2126 5911235 SGTC_3148 9097893 49.47 µM 0.171207522695768 0.421564930614939 no 1401 0.43203029628777 1932 17174100 SGTC_1638 st008370 60.6 µM 0.170630301615319 0.421821478705165 no 1402 0.432257235039339 2080 24207134 SGTC_1452 4194-0072 190 µM 0.166817114338499 0.423517092890213 no 1403 0.433756976042129 2119 1343545 SGTC_1104 tacrolimus 29.8 µM 0.164378954248696 0.4246020171022 no 1404 0.434716415142917 2083 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3343 9148379 18.9835 µM 0.164250465491839 0.424659207516735 no 1405 0.43476698740316 2123 1955036 SGTC_2769 toremifene 3.73 µM 0.163397205804416 0.425039034042631 no 1406 0.435102851382293 2046 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.163311277714186 0.425077288591325 no 1407 0.435136677389436 1937 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1954 st077032 68.9 µM 0.16323380768712 0.425111778277767 no 1408 0.435167174246126 1896 698907 SGTC_1992 st073643 23.3 µM 0.163195030865448 0.425129041949258 no 1409 0.435182439277507 2077 3161292 SGTC_1546 5-methoxyflavanone 78.7 µM 0.162947118151139 0.425239417555074 no 1410 0.435280035823406 2131 147795 SGTC_2269 7935389 174.42 µM 0.160001192927157 0.42655144748449 no 1411 0.436440067252347 1941 97605 SGTC_892 0929-0076 29 µM 0.158925910239544 0.427030550659619 no 1412 0.436863623354916 1984 5751038 SGTC_2351 9026858 72.31 µM 0.15873381814739 0.427116150606163 no 1413 0.436939296466937 2036 1409300 SGTC_1187 1391-0724 117 µM 0.15859567387255 0.427177712485074 no 1414 0.436993718703141 2014 6997986 SGTC_1849 st056239 19.2 µM 0.156495220327529 0.428113965047665 no 1415 0.43782134322688 1913 5393181 SGTC_637 1181-0519 7.26 µM 0.156282042590549 0.428209009242663 no 1416 0.437905355174861 2093 6252091 YGR060W ERG25 SGTC_1056 3448-1962 115 µM 0.155967267232795 0.428349357826635 no 1417 0.438029411195541 2037 715507 SGTC_1972 st070201 17.4 µM 0.154124944893811 0.429170973494676 no 1418 0.438755610046558 2146 2829099 SGTC_2654 protoveratrine a 100 µM 0.153790570152971 0.429320126737931 no 1419 0.438887434654231 2103 5702278 A heart drug and vasodilator. SGTC_234 nsc-17383 10.7 µM 0.152432828625905 0.429925872695579 no 1420 0.439422783055361 2122 408974 SGTC_1547 harmine 94.2 µM 0.152158790761219 0.430048152640799 no 1421 0.439530847822817 2107 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2144 5628481 200 µM 0.152056865002 0.430093635207834 no 1422 0.43957104262821 2021 2818399 SGTC_761 k216-0224 480 µM 0.151653046978613 0.430273840969521 no 1423 0.439730295899429 2159 1340404 SGTC_151 3013-0144 2.285 µM 0.150930276939644 0.430596416860255 no 1424 0.440015358260913 2137 906558 YHR107C CDC12 SGTC_1334 1486-0610 236 µM 0.150927852252278 0.430597499088446 no 1425 0.440016314616263 2088 3742339 SGTC_3327 9140648 26.9345 µM 0.150003438391358 0.431010137298654 no 1426 0.440380951255785 2127 8029710 SGTC_2062 5245942 200 µM 0.147027134257185 0.432339204072231 no 1427 0.441555301508309 2158 1376160 SGTC_357 1325-0123 420 µM 0.145708242233633 0.432928400315079 no 1428 0.442075857228081 2148 1098503 SGTC_116 0155-0182 31.788 µM 0.144705748034238 0.433376350168326 no 1429 0.442471600327982 1999 771486 SGTC_1161 k007-0610 110 µM 0.144324954314903 0.4335465247303 no 1430 0.442621936950061 2162 5843850 SGTC_3289 9119912 71.43 µM 0.144088622992227 0.433652146061234 no 1431 0.442715244254601 2078 17014829 SGTC_2543 pimpinellin 60.67 µM 0.142899764269238 0.434183543204602 no 1432 0.443184672374147 2005 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2499 avocadenofuran 51.48 µM 0.141312473914555 0.434893216955384 no 1433 0.44381154787106 2102 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_118 0083-0097 135.343 µM 0.140866694387982 0.43509256175693 no 1434 0.443987626881642 2054 5207356 SGTC_1562 morin hydrate 59.1 µM 0.140241009255143 0.435372385015278 no 1435 0.444234785675469 2060 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_179 1273-0063 6.77 µM 0.133545449905732 0.438368818079357 no 1436 0.446881011158692 2075 3108139 SGTC_1875 nocodazole 6 µM 0.13230918840997 0.438922468420635 no 1437 0.447369869985442 2195 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1159 4092-0538 61.2 µM 0.131742225969548 0.439176418294559 no 1438 0.447594092542937 2161 717301 SGTC_1611 st001856 99.4 µM 0.131661872408516 0.439212411730856 no 1439 0.447625872161603 2005 647478 SGTC_1843 st055809 45.5 µM 0.131597192798577 0.439241384569503 no 1440 0.447651453018743 2073 16413835 SGTC_1690 st023502 41.2 µM 0.130766291740893 0.439613610549526 no 1441 0.447980094632579 2175 24207482 SGTC_422 cantharidin 155 µM 0.129333989336265 0.4402553766876 no 1442 0.448546688840529 2064 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3238 9133470 49.47 µM 0.128963920105244 0.440421217749223 no 1443 0.448693098976504 2189 3534688 SGTC_2434 5670830 169.91 µM 0.127040392580737 0.441283385908727 no 1444 0.44945421443883 2078 1549830 SGTC_3147 9097027 49.47 µM 0.126835250961907 0.441375351477465 no 1445 0.449535397402973 2109 25236841 SGTC_852 0418-0143 439 µM 0.126762484237852 0.441407973765689 no 1446 0.449564194692058 2197 5369229 SGTC_2659 sanguinarine 24.21 µM 0.126382099491256 0.441578511761527 no 1447 0.449714735533618 2119 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3283 9109332 35.8195 µM 0.126243603800661 0.441640606263099 no 1448 0.44976954830428 2182 17027281 SGTC_961 1252-1571 372 µM 0.126237960624623 0.441643136409814 no 1449 0.449771781737882 2179 6813498 SGTC_2921 7974240 10.71 µM 0.125575944578156 0.441939971173571 no 1450 0.450033802819178 2123 2979074 YDR527W RBA50 SGTC_1120 ficusin 1.78878 µM 0.125419559166619 0.442010096033656 no 1451 0.450095702199586 2109 6199 A DNA cross-linker. SGTC_1727 st034309 9.9045 µM 0.125299336981994 0.442064006158892 no 1452 0.450143288529815 2190 870305 SGTC_2493 resveratrol 26.09 µM 0.124364219509037 0.442483368819158 no 1453 0.45051345103241 2137 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2884 9058502 51.95 µM 0.123997596355348 0.442647802206342 no 1454 0.450658589103483 2097 6471554 SGTC_1445 4239-0156 97.7 µM 0.123930927694105 0.442677704691255 no 1455 0.450684982474838 2178 4008346 SGTC_286 k060-0067 22.9 µM 0.123315987789868 0.442953535282585 no 1456 0.450928440517425 2115 5985051 SGTC_2521 angolensin 13.4 µM 0.122577429545874 0.443284851273525 no 1457 0.451220864125812 2108 821428 A flavenoid. SGTC_1667 st014849 34.6 µM 0.121417221312164 0.443805398733605 no 1458 0.451680288579126 2185 5348460 SGTC_2151 5563267 85.4165 µM 0.12114030798515 0.443929655047961 no 1459 0.45178995154905 2061 5310824 SGTC_206 4546-0025 72.014 µM 0.120747993716167 0.444105703409307 no 1460 0.451945321793408 2091 6620745 YIL048W NEO1 SGTC_2447 5741742 33.78 µM 0.120608501105646 0.444168302429873 no 1461 0.452000567546756 2145 1776504 SGTC_1260 0700-1617 7.75 µM 0.120489048183951 0.444221909501341 no 1462 0.452047877362535 2105 2853078 SGTC_296 1222-0039 74.9 µM 0.119871356055639 0.444499128408149 no 1463 0.452292527693296 2088 5984176 SGTC_793 0488-0545 106 µM 0.119550859172053 0.444642977431944 no 1464 0.452419474561795 2013 292548 SGTC_2525 harmine 47.85 µM 0.118229446015006 0.445236145776878 no 1465 0.452942929514994 2142 5280953 A monoamine oxidase inhibitor SGTC_3259 9138485 49.47 µM 0.117699968463839 0.445473857118483 no 1466 0.453152695884881 2188 17646153 SGTC_3065 9113888 49.47 µM 0.116540027195502 0.445994686399361 no 1467 0.453612282543189 2151 16648368 SGTC_3329 9141233 27.5565 µM 0.116416778257212 0.446050032328874 no 1468 0.453661119339702 2172 4909101 YNL103W MET4 SGTC_1813 st051246 8.6015 µM 0.115233717950034 0.446581348416484 no 1469 0.454129936811172 2196 5291959 SGTC_3030 9087619 49.47 µM 0.11519438039163 0.446599016689939 no 1470 0.454145526411951 2143 25236973 SGTC_1766 st045414 44.774 µM 0.114487505145421 0.446916524310448 no 1471 0.454425675360367 2195 253960 SGTC_2009 4012297 12.05 µM 0.112745180818587 0.447699270165056 no 1472 0.455116290236813 2074 45595307 SGTC_395 anisomycin 6.25 µM 0.112499255447768 0.447809769553238 no 1473 0.455213780031393 2091 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1675 st018485 24.5 µM 0.111841836150709 0.448105181590682 no 1474 0.455474407573852 2074 3323024 SGTC_856 0433-0016 11.3 µM 0.111562956327343 0.448230505230104 no 1475 0.455584972586681 2115 3911780 SGTC_2420 aureobasidin a 50 nM 0.111395744779904 0.448305649608256 no 1476 0.455651267117657 2188 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2202 7226349 200 µM 0.110948861905412 0.448506486554733 no 1477 0.455828449277071 2193 844334 SGTC_3011 9081274 71.4286 µM 0.110912556269041 0.448522803520339 no 1478 0.455842844287618 2104 6625322 SGTC_2681 menadione 3.18 µM 0.110889262615915 0.448533272511931 no 1479 0.455852080139796 2131 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_792 4534-1957 155 µM 0.109494494442338 0.449160195724178 no 1480 0.456405144157002 2092 1717904 SGTC_3118 9124250 49.47 µM 0.109455673776855 0.449177646738239 no 1481 0.456420538833845 2102 1504786 SGTC_1453 4237-0541 195 µM 0.108024133291339 0.449821234045251 no 1482 0.456988274313337 2221 739892 SGTC_1803 st050068 52.4 µM 0.107117287215697 0.450228999354935 no 1483 0.457347966429507 2232 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2347 9049783 174.81 µM 0.106926560059326 0.45031476693799 no 1484 0.457423621050735 2166 6467988 YPL169C MEX67 SGTC_1378 2093-0007 380 nM 0.106668657212796 0.45043074626647 no 1485 0.457525924311769 2116 3618014 SGTC_2029 5175081 200 µM 0.10642625875118 0.45053975710713 no 1486 0.457622079957828 2216 1380876 SGTC_3126 9127922 49.47 µM 0.106274126693456 0.450608175468691 no 1487 0.457682429612689 2150 45595682 SGTC_2862 9027634 71.43 µM 0.106229841222836 0.45062809225257 no 1488 0.457699997512651 2163 5012562 SGTC_2480 5767542 37.17 µM 0.105759941120816 0.450839431036179 no 1489 0.45788641041574 2173 2867358 SGTC_2295 7971645 200 µM 0.10476231424076 0.451288162434308 no 1490 0.45828220716182 2150 2978226 YKL099C UTP11 SGTC_2064 5220758 200 µM 0.104454802408808 0.45142649347399 no 1491 0.458404217228129 2132 788518 SGTC_1207 2099-0101 141 µM 0.104204775284484 0.451538969956721 no 1492 0.458503422238528 2211 5837381 SGTC_2557 derrustone 83.84 µM 0.104183596425725 0.45154849759604 no 1493 0.458511825641238 2041 629853 An antioxidant. SGTC_1146 3579-1023 7 µM 0.103509115086265 0.451851938095106 no 1494 0.458779457780996 2213 X1146 SGTC_164 4100-3994 89.624 µM 0.103423361986007 0.451890519333738 no 1495 0.458813485691166 2223 4615967 SGTC_458 nppb 133 µM 0.102612224428885 0.452255481236664 no 1496 0.459135370183186 2230 4549 A chloride channel blocker. SGTC_74 000s-0487 160.283 µM 0.101370160822722 0.452814411388054 no 1497 0.459628311323155 2238 677548 SGTC_2110 5483698 200 µM 0.100808606761837 0.453067142167076 no 1498 0.459851197220849 2118 2848765 YHR062C RPP1 SGTC_826 1683-5028 118 µM 0.100565694365491 0.453176472247269 no 1499 0.459947615266794 2130 722377 SGTC_264 promethazine 12.5 mM 0.100232404842755 0.453326485064242 no 1500 0.460079910101426 2247 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1212 0520-0165 585 µM 0.100087644915054 0.453391643237384 no 1501 0.460137372003173 2248 5403258 SGTC_1412 3909-8563 178 µM 0.0996018693972877 0.453610305762477 no 1502 0.46033020482182 2245 23767530 SGTC_184 1494-0393 24.714 µM 0.0986703105132817 0.45402966840221 no 1503 0.460700021290155 2162 3090647 SGTC_1653 st012112 65 µM 0.0984608875057317 0.454123952055009 no 1504 0.460783164125992 2217 720429 SGTC_2974 9094440 9.66 µM 0.0970749414346886 0.454747979257081 no 1505 0.461333440348109 2163 25236134 SGTC_752 1896-0090 130 µM 0.0969990193939566 0.454782166669804 no 1506 0.461363586594354 2232 772567 SGTC_2143 5623677 140.463 µM 0.0966721252364959 0.4549293697163 no 1507 0.461493388481023 2224 5375313 SGTC_1900 st060200 72.8 µM 0.0956769830205181 0.455377528209154 no 1508 0.461888560954399 2183 688945 SGTC_2287 7945887 168.79 µM 0.0935683337580452 0.456327337312348 no 1509 0.462726032611586 2221 1245853 SGTC_2905 7799065 20.05 µM 0.0926863734517746 0.456724677309472 no 1510 0.463076361408562 2241 1296806 SGTC_1313 1220-0047 237 µM 0.0925381579939602 0.456791455467587 no 1511 0.463135237786773 2172 3528706 SGTC_982 1491-0518 27.5 µM 0.09230196063614 0.456897876203852 no 1512 0.463229065329774 2155 3091256 SGTC_1671 st016596 74.5 µM 0.0920217707938777 0.457024122137505 no 1513 0.463340371193438 2234 2829167 SGTC_1086 cerivastatin 2.18 µM 0.0918613020510726 0.457096426949256 no 1514 0.463404118951604 2261 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.0918328265270057 0.457109257742296 no 1515 0.463415431226824 2249 1273210 SGTC_2612 dictamnine 15.46 µM 0.0908137216742098 0.457568485768211 no 1516 0.463820303393463 2140 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_465 cgp-37157 41 µM 0.0903874306103952 0.457760597469939 no 1517 0.46398967236328 2237 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2662 daunorubicin 22.37 µM 0.0902065336314753 0.4578421232207 no 1518 0.464061546205082 2208 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1064 honokiol 6.76 µM 0.0896397167442001 0.458097584907199 no 1519 0.464286761017979 2138 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2294 7971431 200 µM 0.0888083960745817 0.458472288477972 no 1520 0.46461709247862 2216 5741572 SGTC_2566 crystal violet carbinol 226 nM 0.0873644388875268 0.4591232150073 no 1521 0.465190917461689 2020 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1620 st003704 16.5 µM 0.0870860635939912 0.459248717439107 no 1522 0.46530155146893 2238 2834414 SGTC_1870 st057514 26.5 µM 0.0869558884883104 0.459307406844634 no 1523 0.465353287561419 2213 5393161 SGTC_5 0352-0601 109.883 µM 0.0864276775226268 0.459545559679485 no 1524 0.465563222881311 2171 762456 SGTC_2329 6138490 200 µM 0.086303772846555 0.459601426300486 no 1525 0.465612469685479 2115 720019 SGTC_3117 9124945 49.47 µM 0.0860824572936295 0.459701215899704 no 1526 0.465700434452772 2125 17592065 SGTC_85 0868-0259 160.055 µM 0.0857096026591888 0.459869339124584 no 1527 0.465848634202001 2188 83173 SGTC_3068 9116768 49.47 µM 0.0841961711291826 0.460551831227694 no 1528 0.466450231188503 2178 41904888 SGTC_252 miconazole 1.30953 nM 0.0840441000905472 0.460620415142203 no 1529 0.466510684486822 2266 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1418 3966-3099 2.4 µM 0.0839224724447848 0.4606752699546 no 1530 0.466559036079585 2233 740335 SGTC_2123 5259487 200 µM 0.0835810081515239 0.460829276436352 no 1531 0.466694783695994 2247 2173474 SGTC_2365 9042475 200 µM 0.0834045622091909 0.460908859004772 no 1532 0.466764930517577 2162 6464479 SGTC_2081 5214970 32.255 µM 0.083334114262307 0.460940633641675 no 1533 0.466792937681682 2253 2063512 SGTC_935 2996-0153 430 µM 0.0826586334006559 0.461245313192968 no 1534 0.467061489012996 2275 23738523 SGTC_956 1185-0240 191 µM 0.0811941101849853 0.461905972756216 no 1535 0.467643791722103 2207 1416193 SGTC_2428 5615643 7.78 µM 0.0804866054644079 0.462225172255802 no 1536 0.467925124481548 2218 2253075 SGTC_797 k781-0471 270 µM 0.0799200936023615 0.46248077863471 no 1537 0.468150404281348 2206 23738129 SGTC_1354 1498-1681 81 µM 0.0793537249646205 0.462736335880181 no 1538 0.468375637322462 2168 5754243 SGTC_1181 1222-0449 220 µM 0.0783266773069486 0.463199800193393 no 1539 0.468784098612286 2235 658318 SGTC_1961 st076550 68.7 µM 0.0783150171939263 0.4632050622102 no 1540 0.46878873607906 2206 1579337 SGTC_102 gallobenzophenone 83.616 µM 0.0772080309168332 0.463704656058028 no 1541 0.469229026485961 2274 70837 SGTC_1314 1222-0010 41.1 µM 0.0771160069426946 0.463746189974938 no 1542 0.4692656296106 2189 3526027 SGTC_1258 0671-0043 57.1 µM 0.0770439814565401 0.463778698089857 no 1543 0.46929427838989 2186 4298767 SGTC_2092 5303694 80.6725 µM 0.0765257234696266 0.464012616716943 no 1544 0.469500424803374 2201 1963699 SGTC_1712 st032288 53.4 µM 0.0762194052720952 0.464150880995166 no 1545 0.469622272210608 2255 2883011 SGTC_575 k072-0246 11.9 µM 0.0751911511148905 0.464615040449774 no 1546 0.470031312406023 2261 6796779 SGTC_1722 st034304 3.6505 µM 0.0735928175021821 0.4653366322119 no 1547 0.470667193222763 2221 4036148 YLR033W RSC58 SGTC_2589 lobaric acid 100 µM 0.0733775993021928 0.465433804467433 no 1548 0.470752821350488 2199 73157 A novel microtubule depolymerizer. SGTC_696 1560-0013 611 µM 0.0714892616110885 0.466286487537792 no 1549 0.471504185342355 2248 1650269 SGTC_502 l-744,832 89.3 µM 0.0697898380388104 0.467053998456476 no 1550 0.472180467763447 2295 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1807 st050092 58.9 µM 0.0696873216910602 0.467100301876522 no 1551 0.472221266536458 2218 5008496 SGTC_289 k017-0060 526 µM 0.0694019624328541 0.467229192048992 no 1552 0.472334833446197 2268 5512909 SGTC_2850 9015429 58.44 µM 0.0687271379722846 0.467534008286306 no 1553 0.47260340814699 2230 6457570 SGTC_3061 glucosamine 200 µM 0.0686027550301129 0.46759019378116 no 1554 0.472652912919478 2272 91431 and experimental redox chemotherapeutic SGTC_245 methotrexate 289.6 µM 0.0685001915272309 0.467636523619357 no 1555 0.472693733809518 2221 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_950 1165-0508 94.1 µM 0.0656577495597266 0.468920679642106 no 1556 0.473825155378758 2219 6148369 SGTC_2536 dehydroabietamide 32.04 µM 0.0655009339367216 0.468991535206776 no 1557 0.473887581380316 2280 3983547 SGTC_2335 9018011 154.17 µM 0.0652081946874435 0.46912380912342 no 1558 0.474004118300271 2249 6458208 SGTC_2359 9039622 200 µM 0.0649813369261709 0.469226316904778 no 1559 0.474094429909871 2248 6463596 SGTC_2087 5276107 200 µM 0.0643913680696704 0.469492909332548 no 1560 0.474329301523569 2290 144405 SGTC_531 3788-1495 174 µM 0.0637920020324741 0.46976376212033 no 1561 0.474567923371292 2256 2896655 SGTC_3228 9131799 49.47 µM 0.0633407909231826 0.46996767311321 no 1562 0.474747567249453 2210 17015818 SGTC_1658 st012944 20 µM 0.0632092312537465 0.470027128947698 no 1563 0.474799947001809 2270 24207260 SGTC_1556 plumbagin 1.48 µM 0.0615012710698195 0.470799068515701 no 1564 0.475480001078535 2292 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3207 9114163 49.47 µM 0.0614717077485827 0.470812431099954 no 1565 0.475491772864143 2296 849233 SGTC_3216 9129716 49.47 µM 0.0603495927409428 0.471319649841044 no 1566 0.475938602298892 2265 8056934 SGTC_764 1951-2361 146 µM 0.0595578362790762 0.471677567863687 no 1567 0.476253900248553 2233 5438930 SGTC_2765 myclobutanil 7.74 µM 0.0592864260160871 0.471800265699788 no 1568 0.476361986283577 2225 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.0592071296481637 0.471836114123157 no 1569 0.476393565484399 2289 6710655 SGTC_191 3914-0123 66.505 µM 0.0583633563124945 0.472217582537845 no 1570 0.476729601211084 2272 3144412 SGTC_1981 st071826 47 µM 0.0581511054734401 0.472313544787793 no 1571 0.476814133475659 2202 11838600 SGTC_2619 obliquin 87.91 µM 0.057727418002219 0.472505105971256 no 1572 0.476982876850298 2275 6708593 A bioactive alkalod. YER133W GLC7 SGTC_123 0083-0120 66.675 µM 0.0568427014582992 0.472905131994194 no 1573 0.477335249031369 2257 16001701 SGTC_2393 9031399 185.94 µM 0.056455108699173 0.473080391322539 no 1574 0.477489628261686 2279 1526623 YDL150W RPC53 SGTC_1505 k297-0037 20.6 µM 0.0559859361861912 0.473292545854922 no 1575 0.477676505442953 2256 4089396 SGTC_853 0419-0306 21 µM 0.0551933092437468 0.473650980020861 no 1576 0.477992229631148 2210 762713 SGTC_3093 9117344 49.47 µM 0.0549658742855461 0.473753832431357 no 1577 0.478082825524377 2246 24824913 SGTC_379 3970-0972 5.9 µM 0.0544754208871242 0.473975635037652 no 1578 0.478278195397727 2237 2898042 YBL034C STU1 SGTC_445 e6 berbamine 66 µM 0.0540169652793248 0.474182974262216 no 1579 0.478460823818282 2249 6610268 A calcium/calmodulin antagonist. SGTC_3187 9109394 49.47 µM 0.0526513355023829 0.474800629521996 no 1580 0.47900485692328 2266 17098090 SGTC_2958 9077254 16.72 µM 0.0513764712648336 0.475377287492238 no 1581 0.479512766608999 2252 16457351 SGTC_2887 9044784 58.44 µM 0.050590709289189 0.475732736132617 no 1582 0.479825833129805 2322 6465546 SGTC_2592 piperlongumine 83.33 µM 0.0499234224312291 0.476034606340497 no 1583 0.480091706086244 2256 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2737 bleomycin 30.5 nM 0.049902545448457 0.476044050985978 no 1584 0.480100024429134 2314 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_210 3551-0445 56.827 µM 0.0495741346784307 0.476192624188953 no 1585 0.480230879408672 2282 2865180 YOR207C RET1 SGTC_2488 5268135 45.7 µM 0.0486996954845547 0.476588237018378 no 1586 0.480579309278778 2277 1270356 YLR208W SEC13 SGTC_1795 st049545 62.3 µM 0.0464337873988911 0.477613483107153 no 1587 0.481482253548131 2349 5291882 SGTC_2810 7959871 45.46 µM 0.0461036872007308 0.477762854709885 no 1588 0.481613803587059 2279 2974535 SGTC_71 0417-1750 47.813 µM 0.0458605187872041 0.477872891346861 no 1589 0.481710711245524 2330 6811472 SGTC_3349 9149703 23.001 µM 0.0439936542373889 0.478717725615099 no 1590 0.482454731078414 2324 4910494 SGTC_1755 st041960 45.185 µM 0.0439623311706166 0.478731901438883 no 1591 0.482467215095818 2285 2257073 SGTC_776 4476-4378 112 µM 0.0436048930648894 0.478893668458003 no 1592 0.482609675653821 2200 2892008 SGTC_52 0329-0193 875 nM 0.0433843721620396 0.478993472113582 no 1593 0.482697567589932 2305 3739292 SGTC_519 k048-0011 62.8 µM 0.0422737693255139 0.479496130176418 no 1594 0.483140227816877 2241 6836379 SGTC_3244 9134489 49.47 µM 0.0420633295354525 0.47959137877667 no 1595 0.483224106537288 2233 16584271 SGTC_1784 st039334 36.3 µM 0.0412507663907241 0.479959169457373 no 1596 0.483547991180292 2329 3496984 SGTC_1391 3442-0225 151 µM 0.0397728645240039 0.480628156108363 no 1597 0.484137105040283 2325 5227075 SGTC_1733 st037357 54.9 µM 0.0395358296384901 0.480735457380627 no 1598 0.484231593958246 2346 1272339 YGL099W LSG1 SGTC_3131 9127911 49.47 µM 0.0392294237686057 0.480874163671062 no 1599 0.484353737455741 2295 45595681 SGTC_221 trifluoperazine 10.304 µM 0.0385545653836506 0.481179672172602 no 1600 0.484622763454077 2323 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1294 1000-1494 117 µM 0.0381774998919136 0.481350374607512 no 1601 0.484773080150086 2302 712797 YDL207W GLE1 SGTC_1548 st061468 90.8 µM 0.0379396519823581 0.481458053199494 no 1602 0.484867899041959 2332 390799 SGTC_2385 9074692 200 µM 0.0373035958147394 0.481746015403087 no 1603 0.485121469222232 2302 17046906 SGTC_2285 7945142 200 µM 0.0365583150632734 0.48208343904449 no 1604 0.485418590527584 2316 2970608 SGTC_1487 3970-0795 2.82 µM 0.0360447418557451 0.482315965269314 no 1605 0.485623341636839 2277 3765103 SGTC_2097 5376186 200 µM 0.0354762529071647 0.482573362244348 no 1606 0.485849990943917 2339 742755 SGTC_1400 3771-8998 51.5 µM 0.0354645142188408 0.482578677293298 no 1607 0.485854671057941 2303 670767 SGTC_535 2293-4129 48.2 µM 0.0354312989011389 0.482593716557608 no 1608 0.485867913729848 2346 396118 YIL048W NEO1 SGTC_3017 9080681 49.47 µM 0.0335841229479018 0.483430121084021 no 1609 0.486604391589399 2283 16451914 SGTC_3056 9094900 49.47 µM 0.0326521104194493 0.483852165909438 no 1610 0.486976006927883 2338 25236784 SGTC_1092 toremifene 6.32 µM 0.0323687960476887 0.483980463247964 no 1611 0.487088973294522 2347 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2678 equilin 100 µM 0.031954332250251 0.484168153859221 no 1612 0.487254234933201 2353 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1968 st069590 43.6 µM 0.0313024332616923 0.484463374468728 no 1613 0.487514174949071 2339 6384066 SGTC_990 3985-0011 41.3 µM 0.0298354030975195 0.485127768327724 no 1614 0.488099161868813 2322 5399565 YGL099W LSG1 SGTC_1951 sophoraflavanone G 9.2 µM 0.0297088232564903 0.485185096219381 no 1615 0.488149637543972 2354 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_641 4092-0595 30 µM 0.0290845095402113 0.485467851774635 no 1616 0.488398595084275 2330 786260 SGTC_3197 9113331 49.47 µM 0.0287526862515725 0.485618139583519 no 1617 0.488530918081669 2323 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1303 1160-0052 261 µM 0.0287367879168863 0.485625340232297 no 1618 0.48853725797982 2348 3562476 SGTC_2801 7907800 81.82 µM 0.028261093444048 0.485840793183592 no 1619 0.488726955564952 2336 6620925 SGTC_3281 9140613 49.47 µM 0.0282567592838971 0.485842756243357 no 1620 0.488728683954431 2272 16013766 SGTC_3140 9094243 49.47 µM 0.0281929363800672 0.485871663423131 no 1621 0.48875413546933 2368 19291112 SGTC_911 3456-4043 236 µM 0.0273454208851407 0.486255533895528 no 1622 0.489092114885741 2337 914281 SGTC_2867 9039098 71.43 µM 0.0248668089483715 0.487378258820921 no 1623 0.490080600832645 2367 6463460 SGTC_2276 7947513 42.08 µM 0.0238907875505662 0.487820390484355 no 1624 0.490469861328393 2297 2105100 SGTC_6 0844-0013 19.835 µM 0.0231043361202047 0.488176659039738 no 1625 0.490783523443431 2365 1584900 SGTC_152 4469-0003 551.229 µM 0.0223299514771197 0.488527470467907 no 1626 0.49109237850565 2365 697280 SGTC_589 1227-0070 34.1 µM 0.0217683453867315 0.488781894607905 no 1627 0.49131637246147 2346 2841384 SGTC_1818 st052136 56.3 µM 0.0214301132685983 0.488935125952735 no 1628 0.491451276081599 2337 674169 SGTC_1480 1070-0044 41.2 µM 0.0213611811534151 0.488966354887415 no 1629 0.491478769723164 2353 3124987 SGTC_1302 1159-0335 255 µM 0.0205468033833071 0.4893353048243 no 1630 0.491803588122104 2351 649284 SGTC_1674 st016616 23.6 µM 0.0194677555070664 0.48982417628562 no 1631 0.492233979772015 2368 625830 SGTC_1578 josamycin 24.2 µM 0.0192534024583864 0.489921292530051 no 1632 0.49231947824062 2345 5282165 A P450 substrate. SGTC_1573 oleylamine 1.06 µM 0.0192361675992155 0.489929101098139 no 1633 0.492326352681507 2352 5356789 An amine of the fatty acid oleic acid. SGTC_58 0957-0393 9 µM 0.018739622882734 0.490154071406938 no 1634 0.492524409654022 2366 6997992 SGTC_1226 3909-7979 35.4 µM 0.0185236615271344 0.490251918345336 no 1635 0.492610550816799 2369 6615510 SGTC_275 trichlorophene 5.69 µM 0.0185108636519001 0.490257716775777 no 1636 0.492615655555075 2316 62616 SGTC_3153 9100258 49.47 µM 0.0176728122531736 0.490637423506533 no 1637 0.492949934969652 2362 25236848 SGTC_2290 7904846 200 µM 0.0170487898405311 0.490920162900701 no 1638 0.493198846376482 2370 2962154 SGTC_1945 st075991 56.6 µM 0.0163685970642269 0.491228357814062 no 1639 0.493470166152313 2342 1084980 SGTC_2687 chenodiol 100 µM 0.0151601594474347 0.491775912926722 no 1640 0.493952203080977 2368 5702181 A cholesterol synthesis inhibitor. SGTC_2591 skatole 100 µM 0.0151064294708987 0.491800258881378 no 1641 0.493973635785977 2358 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1277 0873-0036 22 µM 0.0148314998035602 0.491924834606633 no 1642 0.494083304566645 2372 5965735 SGTC_1950 st077106 7.18 µM 0.0141716776992486 0.492223815415397 no 1643 0.494346507820063 2338 13831864 SGTC_61 0978-8327 98.565 µM 0.0132904668893019 0.492623119402283 no 1644 0.494698026919045 2383 6150059 YHR072W ERG7 SGTC_400 oxethazaine 37.5 µM 0.012919018529092 0.492791436428623 no 1645 0.494846200650266 2320 4621 A local anesthetic. SGTC_581 0958-0271 211 µM 0.012220700146731 0.493107873833997 no 1646 0.495124767364682 2382 4591145 SGTC_2429 5902844 64.44 µM 0.0119137341368084 0.493246974417168 no 1647 0.495247220168231 2385 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_605 1315-0399 119 µM 0.011763231523891 0.493315174455477 no 1648 0.495307257816503 2373 24020461 SGTC_2913 7966556 36.57 µM 0.0111611934068301 0.493587989079463 no 1649 0.495547420495102 2384 2976516 SGTC_2596 sinensetin 100 µM 0.0109307356348921 0.493692422221925 no 1650 0.49563935423523 2371 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2873 9040596 71.43 µM 0.0105418539297133 0.493868646973299 no 1651 0.495794486647362 2309 6463863 SGTC_1631 benzylvanillin 81.9 µM 0.00967375162807868 0.494262038509083 no 1652 0.496140791657283 2374 75506 SGTC_3067 9117431 49.47 µM 0.00965646124352547 0.494269873923442 no 1653 0.496147689200554 2380 17150885 SGTC_3295 9122362 53.5725 µM 0.00947415862918201 0.494352487403414 no 1654 0.496220414094078 2361 4730473 SGTC_1748 st037455 53.6035 µM 0.00889196560364671 0.494616319518729 no 1655 0.496452665711103 2383 580690 SGTC_3178 9107506 49.47 µM 0.00872603447934194 0.494691514877644 no 1656 0.496518860083805 2378 8897194 SGTC_936 3005-4620 401 µM 0.00861112340297141 0.494743589484117 no 1657 0.496564701248248 2394 777207 SGTC_2035 5154463 94.595 µM 0.00807564163944885 0.49498625657146 no 1658 0.496778320126197 2394 2769623 SGTC_2086 5274770 176.623 µM 0.00802632416521212 0.495008606125334 no 1659 0.496797994314197 2384 689278 SGTC_883 0850-0245 24.6 µM 0.00367149590560706 0.496982168636019 no 1660 0.498535288341623 2384 6823229 YPR165W RHO1 SGTC_3137 9097352 49.47 µM 0.00365953602390247 0.496987588852828 no 1661 0.49854005961205 2395 44120435 SGTC_1151 3909-8316 15.3 µM 0.00345602014718072 0.497079822305717 no 1662 0.49862125018602 2378 800431 SGTC_2933 9026794 32.47 µM 0.0028732958531816 0.497343913966952 no 1663 0.498853722377309 2394 17586027 SGTC_337 1315-0038 354 µM 0.00278527777216226 0.497383804018039 no 1664 0.498888836370715 2395 1626437 SGTC_1557 sumaresinolic acid 42.3 µM 0.0025820397773227 0.497475912169458 no 1665 0.49896991630773 2398 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1959 st077091 55.8 µM 0.00218753085914102 0.497654705334426 no 1666 0.499127302146625 2396 821356 YKL052C ASK1 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.00216730483989286 0.497663871867699 no 1667 0.499135371141739 2402 5377381 SGTC_3316 9136639 10.545 µM 0.00211928878791569 0.497685632987988 no 1668 0.499154526731011 2382 4903665 SGTC_1958 st076513 41.9 µM 0.00199588441659854 0.49774156051154 no 1669 0.49920375784807 2401 732122 YGL099W LSG1 SGTC_2357 9067248 200 µM 0.00170613870503896 0.497872874995973 no 1670 0.499319349464549 2386 9150235 SGTC_3263 9137018 49.47 µM 0.00122724183422023 0.498089914412288 no 1671 0.499510401466951 2399 43844957 SGTC_2024 5144227 134 µM 0.00104169502206215 0.498174005682712 no 1672 0.499584423887575 2401 3475211 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.000785431032444757 0.498290146665186 no 1673 0.499686658385035 2403 688798 SGTC_1835 st008666 49.2 µM -0.00185272993665722 0.499485789923597 no 1674 0.49926086811696 2407 690455 SGTC_321 4534-3890 65.3 µM -0.00197435988938905 0.499540914135424 no 1675 0.49921234487512 2407 699746 SGTC_277 nystatin 15.5 µM -0.00239729984688628 0.499732595861505 no 1676 0.499043616648341 2408 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2256 7954252 200 µM -0.00264157390019993 0.499843303976076 no 1677 0.498946165709999 2421 2972920 SGTC_1039 k821-0043 94 µM -0.00298421517657675 0.49999859338837 no 1678 0.498809472159297 2388 15992768 SGTC_2989 9073649 71.4286 µM -0.00299042246636539 0.49999859338837 no 1679 0.498806995820003 2414 21367202 SGTC_318 1488-0629 67.2 µM -0.00426823527990769 0.499419472455003 no 1680 0.498297225654288 2422 3662576 SGTC_3081 9117243 49.47 µM -0.0046410796732874 0.49925049483513 no 1681 0.498148483738443 2414 45595589 SGTC_1206 3978-0017 132 µM -0.00494914866302035 0.499110874317205 no 1682 0.498025583406583 2423 3873677 SGTC_1506 4226-2149 212 µM -0.00580823788261475 0.498721525528588 no 1683 0.497682861362357 2434 991114 SGTC_3091 9116372 49.47 µM -0.00588854223550576 0.498685130759267 no 1684 0.497650825108581 2463 17169793 SGTC_1622 st003707 19.4 µM -0.00707923458245681 0.498145498031136 no 1685 0.497175817601446 2452 10140899 SGTC_148 3253-0744 288.01 µM -0.007221237304409 0.49808114129799 no 1686 0.497119168159919 2416 6893655 SGTC_3188 9110789 49.47 µM -0.00725528974166158 0.498065708477113 no 1687 0.497105583558819 2418 849217 SGTC_3269 9137823 49.47 µM -0.00757723627268938 0.497919800032209 no 1688 0.496977149008178 2420 17682936 SGTC_2526 patulin 37.61 µM -0.00784024367321625 0.497800603423737 no 1689 0.496872227353866 2427 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3029 9088683 49.47 µM -0.0078668186991293 0.497788559465557 no 1690 0.496861625779373 2433 25236615 SGTC_3062 9077494 49.47 µM -0.00788037470385662 0.497782415805191 no 1691 0.496856217883564 2411 16459633 SGTC_1524 corynanthine 62.1 µM -0.00804369431466102 0.497708398447282 no 1692 0.496791064850856 2497 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2318 6029776 164 µM -0.00819771051519058 0.497638597518992 no 1693 0.496729623302599 2425 818325 SGTC_1273 0849-0096 14.1 µM -0.00842641389772021 0.497534948112575 no 1694 0.496638387005665 2428 5286025 SGTC_514 4466-0038 2.65 nM -0.00994167986726407 0.496848227262882 no 1695 0.496033908895597 2459 5722064 SGTC_68 0986-0284 82.829 µM -0.0103940057048936 0.496643234220839 no 1696 0.495853466323758 2500 423278 YIL048W NEO1 SGTC_1932 st074806 40.9 µM -0.0107626138039229 0.496476182520722 no 1697 0.495706421196441 2526 17251235 SGTC_209 4077-0173 175.592 µM -0.0113515932424131 0.49620926071512 no 1698 0.495471466762685 2446 15993494 SGTC_1402 3909-7673 35.9 µM -0.0123013006294531 0.495778862880395 no 1699 0.495092614841182 2423 5328014 SGTC_2054 5233173 129 µM -0.0124909002166598 0.49569293882701 no 1700 0.49501698136088 2441 6889 SGTC_1735 st034310 56.75 µM -0.0126822172669551 0.495606236644362 no 1701 0.494940662946149 2538 871153 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.012794876775419 0.495555181044562 no 1702 0.494895721951406 2432 689007 SGTC_505 gw-5074 63.9 µM -0.0138523271226146 0.495075964067379 no 1703 0.494473897760569 2476 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1216 1165-0504 9.65 µM -0.0160912335426687 0.494061357305987 no 1704 0.493580803615274 2437 6304004 SGTC_2109 5483026 200 µM -0.0164372535937973 0.493904554423919 no 1705 0.49344277984432 2442 759335 SGTC_2188 6126565 140.678 µM -0.0177305448558558 0.493318493461257 no 1706 0.492926906601733 2438 874518 SGTC_758 0868-0029 16 µM -0.0180112177938563 0.493191307072272 no 1707 0.492814952178948 2434 762687 SGTC_1952 st077036 64.1 µM -0.018094645773562 0.493153501980468 no 1708 0.492781674653638 2436 2937007 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0186877982099077 0.492884718859712 no 1709 0.492545081087262 2459 115019 SGTC_917 harmaline 728.087 nM -0.0187408990897279 0.492860656701418 no 1710 0.492523900610488 2463 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2082 5219693 150 µM -0.0189889322204273 0.492748263194419 no 1711 0.492424967313972 2430 2834649 SGTC_1448 4255-0083 152 µM -0.0190966532951103 0.492699450743505 no 1712 0.492382000613981 2450 5399660 SGTC_150 3970-0969 77.2 µM -0.0195795758588629 0.492480621808202 no 1713 0.492189378407137 2506 6615640 SGTC_29 0299-0004 12.984 µM -0.0196652015932518 0.492441822057379 no 1714 0.492155225257175 2447 16871 A napthoquinone isolated from Swertia calycina. SGTC_946 3434-1334 87.4 µM -0.020402309578923 0.492107817918869 no 1715 0.491861220728603 2465 4047976 SGTC_2679 rapamycin 1 nM -0.0209195168320563 0.491873460210598 no 1716 0.491654928924831 2445 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_15 0266-0086 27.098 µM -0.0212713646669357 0.491714032002512 no 1717 0.491514593177368 2428 1712902 YIL048W NEO1 SGTC_392 N-ethylmaleimide 8.33 µM -0.0215461046379118 0.491589543591436 no 1718 0.49140501290223 2453 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2917 7979103 53.79 µM -0.0215798926198186 0.491574233854407 no 1719 0.491391536581038 2451 2980565 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.0227101592692312 0.491062103866643 no 1720 0.490940736000795 2445 165521 SGTC_3242 9133940 49.47 µM -0.022950089459583 0.490953392055126 no 1721 0.490845042645384 2512 17248444 SGTC_1694 st024011 44.9 µM -0.0233060971140991 0.490792087055123 no 1722 0.490703054121128 2446 2787533 SGTC_3044 9093193 49.47 µM -0.0234486200628787 0.490727511155653 no 1723 0.490646211225449 2474 25236277 SGTC_64 000l-0018 272.079 µM -0.0234921612393131 0.490707783078456 no 1724 0.490628845592901 2466 6811119 SGTC_2790 5423970 71.43 µM -0.0236610635594524 0.490631255320186 no 1725 0.490561482041061 2471 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3075 9116269 49.47 µM -0.0240964849478685 0.490433972340668 no 1726 0.490387823557534 2467 17015205 YNL244C SUI1 SGTC_159 3970-0959 50 µM -0.0242957294480438 0.490343698387336 no 1727 0.490308359766915 2479 6615653 SGTC_2346 9031566 143.75 µM -0.0251217194645248 0.48996946310011 no 1728 0.489978938010324 2480 4771086 SGTC_2508 celastrol 40.54 µM -0.0258638191158205 0.489633243946848 no 1729 0.489682979274588 2446 122724 Celastrol is a natural product and antioxidant. SGTC_3299 9121982 43.1275 µM -0.0260181807486491 0.489563309058091 no 1730 0.489621418609505 2473 17594604 YPL160W CDC60 SGTC_1006 4099-6547 255 µM -0.0261151507610292 0.489519376109242 no 1731 0.489582746312236 2481 3146833 SGTC_82 0054-0107 293.755 µM -0.0265809773931893 0.489308331846218 no 1732 0.489396972870066 2535 3104697 SGTC_2511 berberine 10.47 µM -0.0267515665504927 0.489231046622226 no 1733 0.489328941835119 2460 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_397 arbidol 50 µM -0.0267766667924493 0.489219675020167 no 1734 0.489318931873154 2524 131410 A RNA synthesis inhibitor. SGTC_2934 9036370 36.88 µM -0.0267842824375145 0.489216224772883 no 1735 0.48931589475964 2484 6462800 SGTC_3008 9078912 71.4286 µM -0.0271722260595773 0.489040469043317 no 1736 0.48916118395889 2468 16648731 SGTC_877 0771-0151 33.1 µM -0.0273302201191048 0.488968891309381 no 1737 0.48909817684836 2511 6166523 SGTC_706 4262-0057 46.9 µM -0.0281128994175474 0.488614311043057 no 1738 0.488786052946474 2454 883298 SGTC_2411 st077133 39.94 µM -0.030465002597179 0.487548783816644 no 1739 0.487848102149763 2633 1403142 YNL221C POP1 SGTC_651 3253-0966 34.4 µM -0.0312893853283915 0.487175350500881 no 1740 0.487519377772802 2469 781462 SGTC_1717 st033143 58.0435 µM -0.0314654054765313 0.487095617394755 no 1741 0.487449190453247 2471 674616 SGTC_1185 1319-0113 81.3 µM -0.0317816958469212 0.48695234638057 no 1742 0.487323071930258 2505 4672763 SGTC_1462 k081-0014 26.5 µM -0.0322696596556833 0.486731315234759 no 1743 0.487128502342724 2441 3270634 SGTC_1683 st010134 710 nM -0.0323192901259302 0.486708834533052 no 1744 0.487108712971934 2467 3818134 SGTC_1716 st033144 30.6155 µM -0.0324985828900512 0.486627622131919 no 1745 0.487037223062039 2477 674617 SGTC_2924 9010168 62.78 µM -0.0326637696960255 0.486552799652469 no 1746 0.48697135802928 2496 2993929 SGTC_2931 9014674 55.67 µM -0.03375160195406 0.486060070629649 no 1747 0.486537614990039 2455 2996810 SGTC_2808 7946468 45.46 µM -0.0351463425924718 0.485428359990574 no 1748 0.485981524087492 2501 2970879 SGTC_2192 5915882 198.485 µM -0.03546875258074 0.485282338115749 no 1749 0.485852981259298 2463 2876149 SGTC_1384 3089-0840 101 µM -0.0360500409277574 0.485019073312192 no 1750 0.485621228986016 2454 1069836 SGTC_2088 5278280 127.392 µM -0.0374653441688335 0.484378111684712 no 1751 0.485056986041618 2504 791502 SGTC_2317 5986382 200 µM -0.0375852900165807 0.484323792517992 no 1752 0.485009168250774 2487 877883 SGTC_1768 st044301 37.178 µM -0.039333616661087 0.483532071711573 no 1753 0.484312202562952 2497 3931349 SGTC_1320 1313-0481 95.3 µM -0.0396273466064032 0.483399063889031 no 1754 0.484195112559323 2479 6813365 YLR208W SEC13 SGTC_2772 vinpocetine 57.06 µM -0.0398506613774692 0.483297942947691 no 1755 0.484106093172442 2497 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2950 9072895 21.46 µM -0.0400962609712123 0.483186732278915 no 1756 0.484008191359505 2508 17332245 SGTC_1979 st071809 45.3 µM -0.0416243143142958 0.482494839710293 no 1757 0.483399095008134 2579 4976333 SGTC_1661 st013063 9.66 µM -0.04212178898875 0.4822695977025 no 1758 0.483200805241254 2481 721395 SGTC_2515 chrysin 20.77 µM -0.0428130319319883 0.481956632490525 no 1759 0.482925287767956 2518 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1295 1013-0063 9.78 µM -0.0443682218661211 0.481252550009955 no 1760 0.482305445985351 2495 6826038 SGTC_2055 5235184 200 µM -0.0450755361170962 0.480932346232478 no 1761 0.482023550474038 2524 2836034 SGTC_1798 st045719 60.953 µM -0.0452574071337693 0.480850014530584 no 1762 0.481951068405803 2478 3980186 SGTC_1591 genipin 88.4 µM -0.0459970957329599 0.480515171272889 no 1763 0.481656282365308 2614 442424 A DNA cross-linking agent. SGTC_960 1222-0186 7.7 µM -0.0461233447282669 0.480458022070112 no 1764 0.481605969701834 2536 3126296 SGTC_1407 3909-7909 12.3 µM -0.047685612049705 0.479750863260613 no 1765 0.480983400489569 2505 4411780 SGTC_378 3970-0959 8.33 µM -0.0485874386391473 0.479342681185863 no 1766 0.480624040328105 2557 6615653 SGTC_2572 astragaloside iv 100 µM -0.0494861621931587 0.478935925148485 no 1767 0.48026593232963 2626 45006101 An anti-inflammatory agent. SGTC_866 0495-0101 262 µM -0.0496326260839246 0.478869638676609 no 1768 0.480207573403786 2515 635694 SGTC_731 3966-0296 387 µM -0.0499193302227107 0.478739884115944 no 1769 0.480093336608228 2504 660956 SGTC_778 3456-2434 196 µM -0.0502721372869161 0.478580216247897 no 1770 0.479952763454899 2613 5539063 SGTC_177 1327-0068 8.361 µM -0.0504077175289138 0.478518858388917 no 1771 0.479898743253921 2489 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1650 st011916 45.8 µM -0.0511350866485734 0.478189690747457 no 1772 0.4796089387255 2501 242528 SGTC_2985 9022375 71.43 µM -0.05193416952485 0.477828086524468 no 1773 0.479290573829478 2662 4939335 SGTC_3190 9110366 49.47 µM -0.0523846442405886 0.477624243905839 no 1774 0.479111104718921 2502 17123768 SGTC_1829 berberine 14.4 µM -0.0525222482679355 0.47756197838992 no 1775 0.479056284122109 2623 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.0525791544989297 0.47753622860714 no 1776 0.479033613145986 2494 229346 A bile salt which induces apoptosis. SGTC_2022 5136654 200 µM -0.0539024936631726 0.476937450976641 no 1777 0.478506424950176 2568 1713771 SGTC_1853 st056710 91.2 µM -0.0547427659272862 0.476557275888129 no 1778 0.478171699070688 2603 269167 SGTC_1180 1193-0155 285 µM -0.0548577515625215 0.476505253123813 no 1779 0.478125895266817 2556 2921347 SGTC_3028 9087778 49.47 µM -0.0550372827159689 0.476424028936492 no 1780 0.478054380740072 2515 17217395 SGTC_113 0099-0221 2.5 µM -0.0565172982103996 0.47575447216458 no 1781 0.477464857785273 2503 89219 SGTC_2161 5662504 8.5105 µM -0.0566701363747191 0.475685332277705 no 1782 0.477403981746004 2542 2859334 SGTC_507 nimesulide 162 µM -0.0568853229351308 0.475587988889927 no 1783 0.477318272990556 2529 4495 A COX2 inhibitor. SGTC_1214 0358-0031 63.7 µM -0.0568895187767099 0.475586090842387 no 1784 0.477316601798276 2653 4301366 SGTC_1606 st000094 49.2 µM -0.0571796949686796 0.475454826935587 no 1785 0.477201026380212 2493 1242210 SGTC_490 phenamil 164 µM -0.0579447043662967 0.475108780606077 no 1786 0.476896336992332 2564 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1301 naphtanilide LB 4.81 µM -0.0590640006386462 0.474602509140116 no 1787 0.476450565944881 2541 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2181 6316240 54.2555 µM -0.0592339905652333 0.474525624173088 no 1788 0.476382868303253 2553 12779990 SGTC_2565 isoliquiritigenin 100 µM -0.0617441641212137 0.473390406447091 no 1789 0.475383284579047 2626 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2241 6772625 37.8075 µM -0.0631286112322064 0.472764386657669 no 1790 0.474832045631327 2500 2285411 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.0632187110654235 0.472723647597537 no 1791 0.47479617265282 2583 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1503 4585-0012 61.3 µM -0.0639016034236035 0.472414883937285 no 1792 0.47452428777149 2655 2922052 SGTC_2973 9094665 17.96 µM -0.0641549261145014 0.472300350557679 no 1793 0.474423433583657 2648 25237061 YIL048W NEO1 SGTC_744 1594-0068 283 µM -0.0649885797822025 0.471923451582352 no 1794 0.474091546523137 2528 668392 SGTC_869 0564-0080 44.1 µM -0.0669322274307622 0.471044817017731 no 1795 0.473317828388211 2583 6843321 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.0677628116928474 0.470669390437313 no 1796 0.472987223828554 2546 65057 A dermal irritant. YDR527W RBA50 SGTC_1619 st003326 88.7 µM -0.067765721597911 0.470668075197115 no 1797 0.472986065606722 2536 2849032 SGTC_2646 retinol 96.75 µM -0.0685433998355225 0.470316586007386 no 1798 0.472676536608367 2589 445354 A vitamin A analog and teratogen. SGTC_534 k292-0788 63.4 µM -0.0694264963709967 0.469917478699657 no 1799 0.472325069372616 2521 4146317 SGTC_554 4483-2211 187 µM -0.0696509005258419 0.469816066117757 no 1800 0.47223576125931 2609 747107 SGTC_1230 0170-0365 3.77 µM -0.0704218116668657 0.469467691405711 no 1801 0.47192896557215 2599 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1763 st044482 94.5 µM -0.0715342365858626 0.468965027897679 no 1802 0.471486288742895 2632 88505 SGTC_1916 st067606 49.2 µM -0.0719234791954663 0.468789155259244 no 1803 0.471331402369955 2607 19590279 SGTC_3074 9116018 49.47 µM -0.0725397688924918 0.468510707733263 no 1804 0.471086178907215 2528 17027303 SGTC_211 3455-0679 143.504 µM -0.073359358857856 0.468140430445775 no 1805 0.470760078675787 2571 748649 SGTC_1009 4106-0057 9.87 µM -0.0742228095707668 0.467750367411619 no 1806 0.470416548247255 2523 2928005 SGTC_975 1335-0046 28.5 µM -0.0742390246781286 0.467743042547391 no 1807 0.470410097153357 2570 16486740 SGTC_518 1021-0119 62.6 µM -0.0746177930540281 0.467571944299592 no 1808 0.470259408390024 2583 1097762 SGTC_816 0325-0417 81.3 µM -0.0748267067214082 0.467477575829278 no 1809 0.470176296244262 2579 68101 SGTC_2781 5567276 71.43 µM -0.0752332533959982 0.467293939724039 no 1810 0.47001456346638 2638 2853274 SGTC_449 xestospongin c 11.1929 µM -0.0754501652029054 0.467195964054419 no 1811 0.469928273430752 2601 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.076730601970101 0.466617651488835 no 1812 0.469418929723383 2646 165506 SGTC_2253 7938677 135.83 µM -0.077335388673339 0.466344522444505 no 1813 0.46917836955234 2690 2301972 SGTC_668 1682-0499 62.6 µM -0.0778305446657636 0.46612091575943 no 1814 0.468981424503995 2578 682214 SGTC_2098 5376439 882.5 nM -0.0779795454258596 0.46605363083982 no 1815 0.468922161912323 2633 2844116 SGTC_2908 7930301 100 µM -0.078080431661146 0.466008073755684 no 1816 0.468882036469178 2542 2223178 SGTC_2906 7926292 26.41 µM -0.0795588721031634 0.465340507465195 no 1817 0.468294053394279 2615 2966319 SGTC_541 4513-1321 94 µM -0.0809783806434926 0.464699642686957 no 1818 0.467729572888426 2567 747515 SGTC_1288 0973-0013 65.5 µM -0.0811047446131598 0.464642597625391 no 1819 0.467679326232817 2622 4315430 SGTC_2015 5119600 184 µM -0.0813369043622235 0.464537794588872 no 1820 0.467587012883412 2617 2828786 SGTC_1376 2910-0861 41.3 µM -0.0817651756424155 0.464344468093268 no 1821 0.467416724563464 2560 1112859 SGTC_2911 7942208 15.64 µM -0.0825338711185486 0.463997491412164 no 1822 0.467111092472495 2616 1243384 SGTC_2981 9013952 38.96 µM -0.0826903275175965 0.463926872874095 no 1823 0.467048888027687 2617 2996344 SGTC_1736 st036774 51 µM -0.0839345686745257 0.463365309821137 no 1824 0.466554227348311 2632 1272247 SGTC_2799 7812892 81.82 µM -0.0844371991909784 0.463138478350221 no 1825 0.466354416099445 2599 20205235 SGTC_1844 rapamycin 4 nM -0.0853389866010139 0.462731541972677 no 1826 0.465995948870612 2549 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1031 k035-0009 16 µM -0.0855588215547265 0.462632346173876 no 1827 0.465908567006071 2681 5180959 SGTC_1360 1598-0022 39.8 µM -0.086200092058396 0.462342999938018 no 1828 0.465653678764755 2643 761525 SGTC_1013 4112-3890 241 µM -0.0866735944958426 0.462129364737534 no 1829 0.46546548297535 2564 705171 SGTC_3066 9117245 49.47 µM -0.0871633163961218 0.46190842312062 no 1830 0.465270848808819 2595 17176980 SGTC_1426 4048-4480 71.7 µM -0.0894015985146427 0.460898756429513 no 1831 0.464381376564637 2580 14224343 SGTC_636 0kpi-0074 126 µM -0.0904111328250243 0.460443447669126 no 1832 0.463980255105502 2614 616434 SGTC_2457 5731572 11.68 µM -0.0918933506519424 0.459775048660362 no 1833 0.463391387260179 2603 2865357 SGTC_2373 9071805 200 µM -0.0921111159578367 0.459676857973306 no 1834 0.463304878371862 2576 10149009 SGTC_1381 2324-0066 62.1 µM -0.0933865856704981 0.459101796441951 no 1835 0.462798223514649 2657 10885928 SGTC_2118 5526350 200 µM -0.0938232600183439 0.458904935932389 no 1836 0.462624777180898 2705 743594 SGTC_1428 4049-0204 61.7 µM -0.095240965624253 0.458265878918118 no 1837 0.462061715997025 2669 X1428 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.096307772916935 0.457785066835606 no 1838 0.461638068945372 2558 2346 DNA damaging agent; causes G2/M arrest. SGTC_886 0866-0150 153 µM -0.0964595551561705 0.457716663294149 no 1839 0.461577797200528 2678 271463 SGTC_108 0509-0257 621.132 µM -0.0986728140366818 0.456719359571676 no 1840 0.460699027379015 2637 536624 SGTC_2878 9043973 25.97 µM -0.0990571251772818 0.456546214957737 no 1841 0.460546456875693 2752 6465167 SGTC_1158 4092-0494 91.8 µM -0.0990707826384875 0.456540061980804 no 1842 0.460541035006562 2707 1148199 SGTC_2090 5301565 104.445 µM -0.0993241776765207 0.456425904015167 no 1843 0.460440441160822 2606 2056344 SGTC_1626 st003712 1.76 µM -0.100579945184352 0.455860216659974 no 1844 0.4599419586929 2691 24207035 SGTC_762 1165-0429 115 µM -0.100792058732201 0.455764674372777 no 1845 0.459857765475565 2569 5967793 SGTC_2068 5226020 147 µM -0.102022217792037 0.455210624542009 no 1846 0.459369519924609 2613 1810509 SGTC_3103 9120822 49.47 µM -0.102275448133887 0.455096583214731 no 1847 0.459269021325445 2745 17141819 SGTC_3132 9126706 49.47 µM -0.103771077264163 0.454423108069128 no 1848 0.458675509761321 2804 850858 SGTC_766 1391-0721 126 µM -0.103852585759471 0.454386408903021 no 1849 0.458643167322279 2728 1020919 YIL115C NUP159 SGTC_747 3448-8087 38.7 µM -0.103868066631545 0.454379438690802 no 1850 0.458637024568221 2635 5168703 SGTC_2849 9019321 12.99 µM -0.104360479310721 0.454157738827701 no 1851 0.458441642159291 2682 16489627 SGTC_590 k048-0076 22.4 µM -0.105480468306342 0.453653537422295 no 1852 0.457997283778366 2668 6832814 SGTC_1344 1488-0097 29.1 µM -0.105841361787864 0.453491084733771 no 1853 0.457854109560325 2681 747966 SGTC_2438 5259590 200 µM -0.106004117358726 0.453417824442039 no 1854 0.457789542707665 2692 1201127 SGTC_2787 5284540 71.43 µM -0.106119191082187 0.453366027880892 no 1855 0.457743892419224 2666 736958 SGTC_942 3253-1115 227 µM -0.106813031028628 0.453053736039669 no 1856 0.457468654677446 2705 46497897 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.107724769385037 0.452643414028673 no 1857 0.457107010358996 2570 2333 A French combination drug. SGTC_1408 3909-7976 48.8 µM -0.108221856804617 0.452419724289513 no 1858 0.456909853777372 2618 24152374 SGTC_2767 sibutramine 71.45 µM -0.108304554805778 0.452382511585612 no 1859 0.456877054829506 2679 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_690 glyoxal 20.3 µM -0.108362651941455 0.452356369105839 no 1860 0.456854013034417 2597 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_3331 9141060 1.957 µM -0.108570021328441 0.452263058961732 no 1861 0.456771769837571 2602 4906567 YPR165W RHO1 SGTC_2838 9002687 71.43 µM -0.109199368364808 0.451979887412265 no 1862 0.456522180643197 2587 6457060 SGTC_2219 9098279 200 µM -0.109694294324375 0.451757215105019 no 1863 0.456325912789453 2611 902349 SGTC_3026 9090633 49.47 µM -0.109976047527148 0.451630458200078 no 1864 0.456214185487156 2591 25236842 SGTC_1113 artemisinin 1.17947 µM -0.110866566302765 0.451229858490038 no 1865 0.455861079171705 2598 2240 An anti-malaria and mitochondrial poison. SGTC_2455 5377712 9.75 µM -0.111240249137495 0.451061772104061 no 1866 0.455712917740085 2670 2243908 SGTC_1713 st033146 12.748 µM -0.112422588018557 0.450530001850946 no 1867 0.455244173103874 2655 674619 SGTC_79 0052-0007 94.094 µM -0.112912331916888 0.450309759959083 no 1868 0.455050029700884 2662 2801472 SGTC_1488 4013-0813 75.9 µM -0.113035533999627 0.450254357367126 no 1869 0.455001191839128 2588 2910057 SGTC_305 1682-2595 20.8 µM -0.113105319236104 0.450222976160588 no 1870 0.454973528958043 2650 226033 SGTC_1235 benzylparaben 21.5 µM -0.113807963857329 0.449907026476055 no 1871 0.454695012685119 2676 7180 SGTC_1053 3366-3204 134 µM -0.114025701006773 0.449809125687431 no 1872 0.454608709928376 2647 3632071 YPR165W RHO1 SGTC_849 0386-0493 241 µM -0.114572561491064 0.449563255210407 no 1873 0.454391964608633 2617 726119 SGTC_1424 4048-1941 275 µM -0.115577759517111 0.449111365068526 no 1874 0.453993595047149 2708 X1424 SGTC_1550 gossypolone 36.6 µM -0.116258805280455 0.448805236133548 no 1875 0.453723716393313 2624 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2539 epi(13)torulosol 80 µM -0.117814965377661 0.448105859432116 no 1876 0.453107135738686 2696 6708597 SGTC_2362 9071156 126 µM -0.118249192197419 0.447910735883124 no 1877 0.452935106802383 2743 653133 SGTC_2724 maprotiline 69.64 µM -0.118601265455666 0.447752537992165 no 1878 0.452795631370774 2627 4011 A tricyclic antidepressant. SGTC_2604 4'-hydroxychalcone 11.32 µM -0.119606456695268 0.447300918907003 no 1879 0.452397452371546 2744 5282362 SGTC_983 1491-0821 12.2 µM -0.120055371310138 0.44709924956171 no 1880 0.452219642572043 2738 46495113 SGTC_2560 caryophyllene 100 µM -0.120306035127368 0.446986647885859 no 1881 0.45212036174897 2604 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_868 0527-0199 213 µM -0.120645435796758 0.446834191193014 no 1882 0.451985939549951 2680 2849450 SGTC_2710 st078562 53.7235 µM -0.120678200449784 0.446819473927928 no 1883 0.451972963152686 2599 17250908 SGTC_2629 bisabolol 100 µM -0.120917417814703 0.446712024213506 no 1884 0.451878222989083 2728 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3113 9123498 49.47 µM -0.121350422980093 0.446517540422289 no 1885 0.451706741658175 2602 8897275 SGTC_2657 nystatin 74.44 µM -0.12163690156214 0.446388875951742 no 1886 0.45159329362387 2670 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_585 0kpi-0023 191 µM -0.122405155518557 0.446043862390365 no 1887 0.451289077851316 2702 64601 SGTC_629 3448-6466 76.7 µM -0.123098723741448 0.445732424365864 no 1888 0.4510144609508 2650 573744 SGTC_1130 3454-2858 15.9 µM -0.123531312934764 0.445538192610517 no 1889 0.450843190019769 2751 715628 YIL048W NEO1 SGTC_2183 6420625 130.508 µM -0.123619288748018 0.445498693229472 no 1890 0.45080835971041 2621 2897619 SGTC_2832 7992762 51.95 µM -0.124553647429584 0.445079218325555 no 1891 0.450438463262084 2626 2985177 SGTC_2193 5925765 200 µM -0.125476660482712 0.444664897345674 no 1892 0.450073100615009 2724 877370 SGTC_1760 st045453 10.4495 µM -0.126636645597955 0.444144290409929 no 1893 0.449613995715097 2657 3323419 YIL048W NEO1 SGTC_2180 6301957 200 µM -0.128246292055923 0.443422033106656 no 1894 0.448977033371148 2650 845462 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.128756665827558 0.443193064686058 no 1895 0.44877509784198 2693 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3174 9107204 49.47 µM -0.129525106549512 0.442848355776989 no 1896 0.448471080062866 2737 3938802 SGTC_525 k781-2675 26.7 µM -0.129843843439429 0.442705388725782 no 1897 0.448344987230932 2629 3651118 YDL195W SEC31 SGTC_1615 st002656 86.5 µM -0.130592913682856 0.442369428263715 no 1898 0.448048674389532 2613 1584458 SGTC_3010 9080089 71.4286 µM -0.130657394061139 0.442340510536289 no 1899 0.448023168969852 2728 17027233 SGTC_1678 st019265 80.2 µM -0.130679759593856 0.442330480263992 no 1900 0.448014322262102 2692 5367020 SGTC_675 1309-0189 238 µM -0.13074525852686 0.442301106164812 no 1901 0.447988414245579 2683 4246530 SGTC_3321 9137793 26.8275 µM -0.13075400670677 0.442297182920267 no 1902 0.447984953931352 2637 4904192 SGTC_1881 5652484 16 µM -0.132387694143935 0.44156463239173 no 1903 0.447338823827038 2684 2255129 SGTC_2812 7970281 58.44 µM -0.135120781271597 0.440339555659888 no 1904 0.446258189888162 2765 2233435 SGTC_969 1313-0238 134 µM -0.13653795799831 0.439704545534704 no 1905 0.44569800968313 2667 5212874 SGTC_2286 7945697 125 µM -0.136697000554612 0.439633291218421 no 1906 0.44563515024367 2723 1245733 SGTC_645 0845-0943 5.41 µM -0.137357572413072 0.439337362476873 no 1907 0.445374082710296 2702 1885106 SGTC_1024 4507-0395 26 µM -0.139524125716403 0.438367009813562 no 1908 0.444517996413628 2823 4201836 SGTC_1787 fluconazole 80 µM -0.140581478865396 0.437893578194272 no 1909 0.444100290318929 2688 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2116 5511452 16.8835 µM -0.141556195297775 0.437457226020927 no 1910 0.443715284745851 2775 870744 SGTC_2266 7929956 200 µM -0.143034152302335 0.436795732955362 no 1911 0.443131604429068 2639 2967153 SGTC_1340 1486-1359 257 µM -0.143197643072349 0.436722569785639 no 1912 0.44306704559773 2708 4309068 SGTC_475 α-linolenic acid 10 µM -0.143486837617681 0.436593158671039 no 1913 0.442952852872483 2881 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_33 0986-0033 35.816 µM -0.144026124783151 0.43635185222413 no 1914 0.44273992005703 2660 2848082 SGTC_3145 9085516 49.47 µM -0.144130273033138 0.43630525335137 no 1915 0.44269879993588 2724 25236195 SGTC_2333 9017922 200 µM -0.145178645788098 0.435836231073366 no 1916 0.442284912745578 2801 3163164 SGTC_2327 6189656 200 µM -0.145270135691098 0.435795304480399 no 1917 0.442248796419065 2764 5349088 SGTC_620 0109-0052 432 µM -0.145525294361209 0.435681166830149 no 1918 0.442148073154272 2702 493037 SGTC_888 0916-0002 6.97 µM -0.1456200304673 0.435638790811009 no 1919 0.442110677258411 2828 2802138 YIL048W NEO1 SGTC_2697 mebhydrolin 72.4 µM -0.147809205367865 0.434659766785897 no 1920 0.441246672154633 2765 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_306 1672-3436 11.6 µM -0.148144777741651 0.43450973024082 no 1921 0.441114255884848 2763 6797378 SGTC_2864 9034755 47.6 µM -0.149847116332792 0.433748749545952 no 1922 0.4404426177678 2653 4930451 SGTC_1327 1436-0082 2.18 µM -0.150192630491454 0.433594327423088 no 1923 0.440306319980667 2713 15992205 SGTC_818 4072-2707 53.5 µM -0.150555215720835 0.433432286553499 no 1924 0.44016329563499 2665 882871 SGTC_163 TUB2.036 7.546 µM -0.151637951399825 0.432948474106853 no 1925 0.439736249315555 2693 15992207 YJR013W GPI14 SGTC_735 3076-0345 636 µM -0.15347427185632 0.43212815797343 no 1926 0.439012139005677 2806 2888990 SGTC_1392 3455-1037 33.9 µM -0.154473300138467 0.431681997381023 no 1927 0.438618280961065 2822 981132 SGTC_2620 irigenin 100 µM -0.154521305817969 0.431660560495503 no 1928 0.438599356674791 2813 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2889 9059656 51.95 µM -0.154702456030825 0.431579669872236 no 1929 0.438527946837219 2769 3949838 SGTC_1101 ebselen 5.29 µM -0.155406624931619 0.431265258323861 no 1930 0.438250380839465 2718 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2774 tamoxifen 10.92 µM -0.156059418276642 0.430973824864864 no 1931 0.437993092944564 2675 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1982 st072467 71.9 µM -0.156529718396621 0.430763887073956 no 1932 0.437807748027491 2652 3163533 SGTC_1044 1222-0021 1.78 µM -0.156994290442932 0.430556525452002 no 1933 0.43762467393529 2815 4306703 SGTC_1023 4482-3888 16 µM -0.157863019263036 0.430168819970352 no 1934 0.437282369479626 2887 3303168 SGTC_1165 k072-0275 30.3 µM -0.158359744015202 0.429947166622279 no 1935 0.437086666537847 2712 6153523 YGL055W OLE1 SGTC_1741 st038134 10.228 µM -0.159365191315014 0.429498573793088 no 1936 0.436690580846619 2861 1272587 SGTC_1439 4092-1168 46 µM -0.160577818771581 0.428957666092317 no 1937 0.436212963108269 2686 2886240 SGTC_2067 5224629 34.075 µM -0.160582628561836 0.428955520889915 no 1938 0.436211068860243 2840 2835000 SGTC_2649 anisomycin 9.56 µM -0.161419892363642 0.428582127009224 no 1939 0.435881350138832 2729 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1928 4'-methoxychalcone 40.3 µM -0.161634928758463 0.428486237700055 no 1940 0.435796674901227 2918 641818 SGTC_402 epigallocatechin gallate 10 µM -0.162670266438122 0.428024617768445 no 1941 0.435389029531791 2713 65064 An antioxidant. SGTC_3012 9080433 71.4286 µM -0.163766905929995 0.427535772973821 no 1942 0.434957322565236 2722 17688859 SGTC_2792 7535235 81.82 µM -0.164174362565572 0.427354170887651 no 1943 0.434796941476655 2778 1281891 SGTC_2516 gossypol 71.55 µM -0.164886575492697 0.427036776910564 no 1944 0.43451662948738 2833 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_737 1950-0117 57.9 µM -0.165533591640173 0.426748478474507 no 1945 0.434262006106516 2735 5393513 SGTC_2564 betulinic acid 100 µM -0.165783180267117 0.42663727684558 no 1946 0.434163791574902 2934 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.166681249691851 0.426237199610924 no 1947 0.433810429854781 2673 1241132 A phosphatase inhibitor. SGTC_2372 9071633 200 µM -0.167670661202741 0.425796518653445 no 1948 0.433421189177467 2693 21321366 SGTC_695 3505-6186 243 µM -0.167893032326124 0.425697487947276 no 1949 0.433333715859986 2823 1819379 SGTC_851 0394-0702 453 µM -0.168046032449219 0.425629353628032 no 1950 0.433273532655997 2709 762646 SGTC_192 3455-0609 60.9 µM -0.169407025548199 0.425023371435822 no 1951 0.432738248893698 2826 3769639 SGTC_3080 9117754 49.47 µM -0.170187004247642 0.424676165656736 no 1952 0.432431535868232 2894 9550191 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.170811324861732 0.424398292818836 no 1953 0.4321860619973 2728 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1012 4112-3522 18 µM -0.171414215603048 0.424129993654273 no 1954 0.431949038886457 2775 3112398 SGTC_2217 6934799 96.0675 µM -0.171812326867907 0.423952844965041 no 1955 0.431792537099352 2749 675606 SGTC_1860 st056228 74.6 µM -0.172376203139436 0.423701961656993 no 1956 0.431570889642675 2829 688679 SGTC_220 paclitaxel 373.376 µM -0.172393414430915 0.423694304388902 no 1957 0.431564124598068 2829 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2307 7538926 6.34 µM -0.172535647420755 0.423631026328201 no 1958 0.431508219479343 2778 96582 SGTC_656 4090-1979 187 µM -0.172725042729415 0.423546769272316 no 1959 0.431433779194497 2794 22330961 SGTC_1372 2752-0194 270 µM -0.173072993916661 0.423391983935402 no 1960 0.431297026160154 2699 823334 SGTC_3186 9110464 49.47 µM -0.173745704225758 0.423092763744245 no 1961 0.43103265848657 2834 17018021 SGTC_2435 5706476 10.6 µM -0.174700820629976 0.422668006126803 no 1962 0.430657361461375 2834 5725375 SGTC_2387 9077560 195.08 µM -0.175887458379355 0.422140412038383 no 1963 0.430191179254941 2712 5303272 SGTC_229 benomyl 22.8748 µM -0.176430712639016 0.421898920908774 no 1964 0.42997778895066 2789 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1047 2043-3044 82 µM -0.177470633281367 0.421436730194446 no 1965 0.429569365160537 2722 669592 SGTC_2922 7999257 32.47 µM -0.177472407146561 0.421435941895779 no 1966 0.429568668547853 2705 2988377 SGTC_3110 9122132 49.47 µM -0.178829231728955 0.420833066889357 no 1967 0.429035895827124 2862 918317 SGTC_1406 3909-7906 11.9 µM -0.178923734167757 0.420791083717932 no 1968 0.428998793165462 2758 X1406 SGTC_703 3875-0075 71.8 µM -0.179828385944892 0.42038923338914 no 1969 0.428643649058809 2746 2850814 SGTC_194 1486-1323 56.904 µM -0.179996601087791 0.420314520612117 no 1970 0.428577618279558 2747 5178754 SGTC_1071 trifluoperazine 6.31 µM -0.182330033497388 0.41927842360729 no 1971 0.427661865191947 2867 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3194 9111903 49.47 µM -0.183867868042811 0.418595895532405 no 1972 0.427058556299386 2908 17087251 SGTC_1242 0402-0103 60.1 µM -0.184483056088452 0.41832292872507 no 1973 0.426817259155189 2723 432868 SGTC_2704 st078022 71.1 µM -0.184832944560415 0.41816769627115 no 1974 0.426680033508713 2877 54697681 SGTC_2785 7756463 72.73 µM -0.184951186811806 0.418115239478524 no 1975 0.426633661110036 2752 2201551 SGTC_3274 9138298 49.47 µM -0.185147507887667 0.418028147145472 no 1976 0.426556669897236 2704 17015756 SGTC_1880 MG-132 525 µM -0.185570203607289 0.417840643707192 no 1977 0.426390910870398 2823 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.186838792163428 0.41727802327071 no 1978 0.425893515346241 2739 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_662 k832-1615 104 µM -0.188990520187689 0.416324117262234 no 1979 0.425050123349315 2814 5878478 SGTC_897 1000-0139 31.4 µM -0.190217812015964 0.415780253399776 no 1980 0.424569226983273 2903 6151020 SGTC_2691 st077356 60.2 µM -0.191622382419933 0.415158028000568 no 1981 0.424019004386066 2910 2839272 SGTC_1758 st042942 75.2445 µM -0.191883908939095 0.415042195067201 no 1982 0.423916571017986 2717 669317 SGTC_1660 st012960 28.1 µM -0.192648722765383 0.414703493136618 no 1983 0.423617042175484 2831 24207266 SGTC_2418 pentamidine 31.67 µM -0.192854895770429 0.414612199147731 no 1984 0.423536304891021 2712 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_627 1391-0720 175 µM -0.193344705414627 0.414395328556763 no 1985 0.423344508465636 2839 997839 SGTC_1337 1486-1011 40.3 µM -0.193371621588531 0.414383411771517 no 1986 0.423333969334093 2747 X1337 SGTC_124 0136-0217 7.121 µM -0.193745607931085 0.414217842351571 no 1987 0.423187539220836 2840 3976905 SGTC_650 1328-0195 38 µM -0.193964056054879 0.414121139108031 no 1988 0.423102013241337 2754 2780821 SGTC_1000 4048-0884 8.67 µM -0.19441373152189 0.413922091875383 no 1989 0.422925969422693 2879 13040088 SGTC_484 loperamide 105 µM -0.196012757527662 0.413214468201824 no 1990 0.422300090313983 2712 3955 An opioid-receptor agonist. SGTC_1450 4112-4260 37.6 µM -0.196814027989126 0.412859984482547 no 1991 0.42198653653929 2841 1633175 SGTC_1275 0867-0008 21.1 µM -0.197723035684475 0.412457923617315 no 1992 0.421630882820746 2758 3422836 SGTC_1333 1482-0047 286 µM -0.197892879262577 0.41238281071032 no 1993 0.421564437766361 2832 3811116 SGTC_1878 temozolomide 1 mM -0.198187529210469 0.412252510105478 no 1994 0.421449172108051 2780 5394 DNA alkylating agent. SGTC_2360 9040895 200 µM -0.200908947502165 0.411049498833937 no 1995 0.420384885635329 2821 4914414 SGTC_3033 9090887 49.47 µM -0.201519190021337 0.410779853621358 no 1996 0.420146312871855 2772 19325384 SGTC_670 4204-0025 119 µM -0.201631988485983 0.410730016466276 no 1997 0.420102217808467 2876 719039 SGTC_1085 doxorubicin 7.67 µM -0.203742508416609 0.409797803085583 no 1998 0.419277360974066 2863 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1192 1488-0095 21.4 µM -0.205111227798176 0.409193513951422 no 1999 0.418742612206386 2844 915875 SGTC_1917 st066507 28.5 µM -0.205284418831072 0.409117065516302 no 2000 0.418674958400337 2772 3156428 SGTC_1497 4476-2978 41.3 µM -0.207577450304196 0.408105223022413 no 2001 0.417779456449328 2851 1528379 SGTC_3055 9094636 49.47 µM -0.207756672501444 0.408026163637727 no 2002 0.417709482359881 2937 25236176 SGTC_773 4358-1457 44.6 µM -0.208810175523069 0.407561512956723 no 2003 0.417298213758814 2879 1186886 SGTC_2803 7707263 71.43 µM -0.20938668786652 0.40730729545087 no 2004 0.417073191994687 2810 2199229 SGTC_406 estrone 100 µM -0.209886699883129 0.407086842953143 no 2005 0.416878051493802 2963 5870 A steroid. SGTC_3202 9113761 49.47 µM -0.211024302404169 0.406585390132508 no 2006 0.416434153882159 2966 4798415 SGTC_368 fentichlor 4.58 µM -0.212482003779759 0.405943062345501 no 2007 0.415865508075126 2856 7329 A pesticide. SGTC_2900 5328528 85.29 µM -0.212721587172634 0.405837515465443 no 2008 0.415772063988375 2780 795359 SGTC_839 0122-0028 230 µM -0.212859561932083 0.405776734702582 no 2009 0.415718252212932 2791 759448 SGTC_2289 7946404 165.07 µM -0.213888935151165 0.405323346085973 no 2010 0.415316834521176 2793 1246120 YPR165W RHO1 SGTC_2846 9008642 19.48 µM -0.214173558415097 0.405198005832446 no 2011 0.415205857495817 2925 2992898 SGTC_2892 9047358 58.44 µM -0.21466976309072 0.404979514205438 no 2012 0.415012399265188 2846 6466771 SGTC_2680 butyl paraben 22.24 µM -0.215164333817142 0.404761771518519 no 2013 0.414819598576312 2766 7184 An antifungal and steroid mimetic. SGTC_45 0kpi-0036 14.9 µM -0.216325647603673 0.404250600539558 no 2014 0.41436695922224 2907 2795021 SGTC_2402 5553605 200 µM -0.21644049129687 0.404200059102863 no 2015 0.414322203349786 2974 6758546 SGTC_2709 st078560 56 µM -0.217001399883813 0.403953232440481 no 2016 0.414103626992273 2927 17250903 SGTC_991 3996-0057 64.7 µM -0.217107550878569 0.40390652521495 no 2017 0.414062264780577 2877 715343 SGTC_887 0885-0007 9.62 µM -0.218165203263969 0.40344122525202 no 2018 0.413650197917053 2923 5719458 SGTC_2607 solasodine 47.35 µM -0.218202742438145 0.403424712903788 no 2019 0.413635574204244 2829 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3087 9117406 49.47 µM -0.219267543001564 0.402956411125324 no 2020 0.413220821816262 2915 42546093 SGTC_1103 duloxetine 36.1 µM -0.219372302012941 0.402910345375931 no 2021 0.413180022169046 2958 60835 A selective serotonin reuptake inhibitor. SGTC_615 k087-0205 167 µM -0.220606173993703 0.402367875611834 no 2022 0.412699546673258 2814 9642773 SGTC_1702 st027038 51 µM -0.220824852665979 0.402271753475997 no 2023 0.412614405801585 2838 5521182 SGTC_2627 acetyl isogambogic acid 100 µM -0.221487933616778 0.401980326553745 no 2024 0.412356265445011 2894 6857789 A caspase activator and apoptosis inducer. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.222552940086716 0.401512365744726 no 2025 0.411941733086517 2833 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1244 0416-0015 52.5 µM -0.223538059718214 0.401079632683529 no 2026 0.411558382527612 2836 96201 SGTC_2951 9072950 58.06 µM -0.226043030763327 0.399979822823075 no 2027 0.410583976309363 2807 16488155 SGTC_1633 st005664 67.9 µM -0.226449613478815 0.399801386867739 no 2028 0.410425871976205 2778 2063822 SGTC_2225 6654152 15.4 µM -0.227569747198892 0.399309904864333 no 2029 0.409990370550584 2856 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1289 0976-0073 69.1 µM -0.227596865817702 0.399298007980405 no 2030 0.409979828364615 2913 3391136 SGTC_1564 D-Arginine 115 µM -0.228345328747287 0.398969695734497 no 2031 0.409688893994225 2838 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_815 1582-0027 36.9 µM -0.228782598180895 0.398777921147923 no 2032 0.409518946373782 2906 3128206 SGTC_1221 2958-7315 257 µM -0.22954944853857 0.398441660280611 no 2033 0.409220946044355 2906 4562705 SGTC_93 0109-0045 59.227 µM -0.229782227085596 0.398339602707447 no 2034 0.409130497978702 2761 88733 SGTC_26 0302-0163 425.158 µM -0.23046714359744 0.398039353717577 no 2035 0.408864395973574 2816 3100915 SGTC_622 1348-1566 26.3 µM -0.231738616397367 0.397482134396069 no 2036 0.408370518071434 2906 7340407 SGTC_1195 1502-0147 41.1 µM -0.233077944542409 0.396895403844435 no 2037 0.407850440500882 2810 817940 SGTC_2075 5212009 200 µM -0.233584128005018 0.396673716552021 no 2038 0.407653925464707 2947 780898 SGTC_276 colchicine 750 µM -0.234018701326492 0.396483418159735 no 2039 0.40748523008726 2929 2833 A microtubule depolymerizer. SGTC_720 r052-1644 49.9 µM -0.235002060071238 0.396052899315322 no 2040 0.407103567143917 2935 1422863 YOR257W CDC31 SGTC_1966 st070145 16.1 µM -0.235086103785065 0.396016110474706 no 2041 0.407070952034095 2777 3748532 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.235865150286856 0.395675138995633 no 2042 0.406768655693728 2879 75037 A free radical scavenger. SGTC_2356 9061756 188.97 µM -0.236091894441735 0.395575913064669 no 2043 0.406680681735267 2903 20104043 SGTC_1283 0922-0125 16.4 µM -0.236799116330573 0.395266467885125 no 2044 0.406406318564131 2939 3360884 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.237301405379057 0.395046731231119 no 2045 0.406211485951812 2864 688788 SGTC_424 splitomicin 100 mM -0.237554890113997 0.394935851797779 no 2046 0.406113170716248 2908 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_440 fluspirilene 35.1 µM -0.238263487923949 0.394625941713232 no 2047 0.40583836917809 3060 3396 An atypical antipsychotic. SGTC_2194 5927483 104.545 µM -0.24181198625275 0.393074988463877 no 2048 0.404462925405464 2824 760979 SGTC_722 3534-0461 190 µM -0.24195082691417 0.393014339255413 no 2049 0.404409132848377 2887 658262 SGTC_2071 5230951 39.92 µM -0.242286712484886 0.39286762645378 no 2050 0.404279004500904 2880 1799272 SGTC_2462 5162487 171.77 µM -0.242945083843292 0.392580097962552 no 2051 0.404023969865925 2797 2259986 SGTC_2281 7943571 200 µM -0.243542408775134 0.39231928080137 no 2052 0.403792618196228 3022 1244024 SGTC_121 0557-0495 61.343 µM -0.24398902565372 0.39212430070039 no 2053 0.403619659688027 2832 3104427 SGTC_1806 st050005 60.3 µM -0.247488841933604 0.390597322766327 no 2054 0.402264962907451 2850 5194765 SGTC_1794 st048918 76.9 µM -0.248242018602125 0.390268929664347 no 2055 0.401973578719866 2846 672303 SGTC_104 0074-0074 590.992 µM -0.249142961691529 0.389876211658625 no 2056 0.401625099169477 2788 3943124 SGTC_1934 st074720 32.6 µM -0.249353254142736 0.389784562063371 no 2057 0.401543770520361 2839 17250992 SGTC_2916 7875993 68.79 µM -0.249464201440669 0.38973621151307 no 2058 0.401500864403294 2861 1299250 SGTC_3280 9140961 49.47 µM -0.249791179327401 0.389593725309099 no 2059 0.401374420720384 2817 4901226 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.249911974596583 0.389541090458125 no 2060 0.401327711308516 2905 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1700 st030840 7.9285 µM -0.250403192666423 0.389327069928615 no 2061 0.401137780429307 2947 5499307 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.250647423312147 0.389220672708691 no 2062 0.401043356639916 2781 4000243 SGTC_593 1203-0218 61.7 µM -0.252153003729717 0.388564961766104 no 2063 0.400461401068533 2993 3666956 SGTC_3000 9075062 71.4286 µM -0.253576009640271 0.387945505423554 no 2064 0.399911566246186 2906 17057871 SGTC_2561 acetosyringone 100 µM -0.255819966000863 0.386969256396598 no 2065 0.399044928073265 2825 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_463 ikarugamyin 104 µM -0.25620537723476 0.386801652265318 no 2066 0.39889612837104 2872 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3268 9137683 49.47 µM -0.257189050012756 0.386373977354418 no 2067 0.398516418297004 2838 1953228 SGTC_273 hydroxyurea 18.1 mM -0.259467701820716 0.385383810698353 no 2068 0.397637199550806 2856 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_3158 9100007 49.47 µM -0.260102263122727 0.385108200707132 no 2069 0.397392446136925 2889 19297233 SGTC_1558 st069300 45.6 µM -0.260632962502154 0.384877745778137 no 2070 0.397187783790735 2952 24208000 SGTC_214 4373-3496 70 µM -0.261730534026953 0.384401257083666 no 2071 0.396764599067914 2908 3779166 SGTC_3234 9132280 49.47 µM -0.263934673108144 0.383444902335733 no 2072 0.39591512869731 2946 17612295 SGTC_2848 9016370 25.97 µM -0.265665052284983 0.382694604410787 no 2073 0.395248590326891 2958 7894410 SGTC_1001 4048-4355 44.4 µM -0.265939565552307 0.382575614953955 no 2074 0.395142876507852 2882 21824233 SGTC_2190 6049624 200 µM -0.267589743383801 0.381860569224625 no 2075 0.394507563369427 2934 2265554 SGTC_907 3448-6986 75.5 µM -0.267956918204 0.381701521814403 no 2076 0.39436624033883 3059 590582 SGTC_1446 4239-0190 62 µM -0.26872229437165 0.381370051602815 no 2077 0.394071697101792 2899 1340085 SGTC_943 3253-1379 105 µM -0.27219925448256 0.379865343367179 no 2078 0.392734407520037 3061 668464 SGTC_2952 9073731 13.78 µM -0.27417710543169 0.379010207040959 no 2079 0.391974260714246 2917 16457353 SGTC_825 1988-2224 89.6 µM -0.275005069788939 0.378652406914112 no 2080 0.391656171651739 2882 1180859 SGTC_621 3584-0052 32.1 µM -0.276091658087342 0.378183001734193 no 2081 0.391238833822463 2988 2273927 SGTC_2413 inermin 26.06 µM -0.276409100308772 0.378045900872974 no 2082 0.391116933930655 3187 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1267 0828-0272 9.49 µM -0.278504335177337 0.377141370939729 no 2083 0.390312618822452 3029 745334 SGTC_1205 4161-2785 76 µM -0.279165759392364 0.376855968400285 no 2084 0.390058809732555 3011 3498106 SGTC_2386 9075165 157.42 µM -0.279756279099515 0.37660121778088 no 2085 0.389832248504368 2886 16452277 SGTC_1949 st076024 69.1 µM -0.279905903581191 0.376536678201061 no 2086 0.389774848897988 2833 2921930 SGTC_2752 diclazuril 33.15 µM -0.281210732980486 0.375973994699005 no 2087 0.389274386483923 3047 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2874 9043904 71.43 µM -0.282274452151532 0.375515480478821 no 2088 0.38886653680307 2967 4463428 SGTC_202 3594-0513 34.79 µM -0.282565946972235 0.375389862821592 no 2089 0.388754793632644 2898 708429 SGTC_125 0133-0007 11.75 µM -0.283832235594817 0.374844318097399 no 2090 0.388269474781809 3036 26541 SGTC_2037 5169046 200 µM -0.285474876570283 0.374137005718239 no 2091 0.387640174765486 3017 5718022 SGTC_1417 3966-0327 90.4 µM -0.286338951644845 0.373765109453979 no 2092 0.387309263680675 2943 651118 SGTC_1937 st074714 47.2 µM -0.286399071189836 0.373739238484564 no 2093 0.387286243002621 2860 17250970 SGTC_1495 4469-0029 237 µM -0.286983306660888 0.373487856743384 no 2094 0.387062551106731 2893 793680 SGTC_2954 9074818 52.69 µM -0.287942306331749 0.37307534018042 no 2095 0.386695450945115 3085 16648742 SGTC_1293 1000-1278 195 µM -0.288665956474089 0.372764156187951 no 2096 0.386418508457836 3051 678847 SGTC_59 0330-0160 1.33 µM -0.289971678750399 0.372202879724613 no 2097 0.385918952136241 2950 4293482 SGTC_2218 6965428 192.983 µM -0.290437454826498 0.372002727299775 no 2098 0.385740796574949 2982 675684 SGTC_3038 9091290 49.47 µM -0.291111619385516 0.371713087829477 no 2099 0.38548297680681 3079 25236843 SGTC_2925 9010536 32.5 µM -0.291354776819674 0.37160863857487 no 2100 0.385389998873622 2977 2994177 SGTC_1848 st056003 16.4 µM -0.291456814768469 0.371564810578134 no 2101 0.385350983818961 2966 146492 SGTC_2244 6635614 200 µM -0.292384677003852 0.371166345685526 no 2102 0.38499626130197 2845 836499 SGTC_573 3702-0553 84.7 µM -0.292575428436347 0.37108444571884 no 2103 0.384923348782819 2927 1222756 SGTC_1643 st009866 20.2 µM -0.293587704244728 0.370649918433136 no 2104 0.384536486266027 3012 3156273 YOR207C RET1 SGTC_2630 antimycin a 100 µM -0.296114881747107 0.369565828770559 no 2105 0.383571174687444 2874 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2302 7771753 200 µM -0.296239232943092 0.369512512202683 no 2106 0.383523694580143 3006 2203047 SGTC_2315 7733312 200 µM -0.296659352958419 0.369332400956778 no 2107 0.383363296169018 2943 726316 SGTC_2755 lomerizine 42.69 µM -0.29670350289236 0.369313474935579 no 2108 0.383346441242944 2957 3949 A calcium channel blocker. SGTC_1292 0kpi-0043 232 µM -0.29708813345784 0.369148606411465 no 2109 0.383199611867528 2974 3333905 SGTC_964 1287-0107 19.4 µM -0.297116990348072 0.369136238128352 no 2110 0.383188596676809 3096 51516812 YPR165W RHO1 SGTC_3308 9128332 17.569 µM -0.298462493783474 0.368559695729777 no 2111 0.382675098973761 3097 17332805 YDL196W YDL196W SGTC_2665 lovastatin 100 µM -0.299478926936794 0.368124354549051 no 2112 0.382287324253133 2953 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2066 5222451 176 µM -0.300018580441647 0.367893288200118 no 2113 0.382081491476748 2927 2281147 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.301732470276913 0.367159760068062 no 2114 0.381428006765099 3037 7104 SGTC_725 1497-0963 19 µM -0.302198972277204 0.366960185553423 no 2115 0.38125019382164 3058 3549977 SGTC_432 NS 1619 61.3 µM -0.302917538400735 0.366652845677253 no 2116 0.380976352607063 3118 4552 A K+/calcium channel activator. SGTC_1170 0310-0127 64.8 µM -0.304609415572478 0.365929546146286 no 2117 0.380331824019518 3012 774975 SGTC_345 1362-0200 395 µM -0.304762218122388 0.365864244476795 no 2118 0.380273629492845 2965 1419823 SGTC_2546 rhodinyl acetate 100 µM -0.305194717958359 0.365679432498674 no 2119 0.380108927543333 3097 6708682 SGTC_838 0109-0203 71.4 µM -0.305629875905993 0.365493516140286 no 2120 0.379943235287499 2932 759422 SGTC_2939 9044578 71.43 µM -0.305915737624631 0.365371402116543 no 2121 0.379834401574161 2907 2653634 SGTC_1215 3852-0577 11.2 µM -0.30639597790841 0.365166284445324 no 2122 0.379651585182793 3103 2884876 SGTC_676 falcarinol 140 µM -0.306865244597801 0.364965891013519 no 2123 0.379472972168613 3137 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_979 1426-2828 121 µM -0.308887887464387 0.364102573800636 no 2124 0.378703405485237 3080 747872 SGTC_2597 laccaic acid a 100 µM -0.309059852170514 0.364029206465456 no 2125 0.378637999203925 3084 5491415 A textile dye. SGTC_1836 st055642 81 µM -0.31020320366769 0.363541531737398 no 2126 0.378203217222155 2975 8571 SGTC_2154 5570129 200 µM -0.31082794994454 0.363275151489032 no 2127 0.377965710221222 2961 673366 SGTC_3034 9090421 49.47 µM -0.311500982165024 0.362988256982392 no 2128 0.377709898172108 2958 17173761 SGTC_806 3966-4455 5.86 µM -0.311820128869961 0.362852240671982 no 2129 0.37758861280204 2968 714982 SGTC_789 1309-1135 70.6 µM -0.312387087392201 0.362610652759324 no 2130 0.377373181242138 2932 3092424 SGTC_992 3909-8734 162 µM -0.312959636178114 0.362366738265865 no 2131 0.377155664225202 3001 4288319 SGTC_2793 7325131 81.82 µM -0.313487883170615 0.362141746552929 no 2132 0.376955012467313 3017 4176441 SGTC_2893 9048488 25.97 µM -0.314644964191389 0.361649087449635 no 2133 0.37651561767476 2994 6467338 SGTC_760 0568-0725 82.9 µM -0.315198007645427 0.361413694891629 no 2134 0.376305659097245 3093 3916171 SGTC_77 0828-0286 12.516 µM -0.315535015648562 0.361270279478476 no 2135 0.376177734613069 2983 745345 SGTC_1297 1068-0111 14.1 µM -0.316205697079139 0.360984925716843 no 2136 0.375923191897001 2962 767057 SGTC_1944 st076371 56.9 µM -0.317223888996235 0.36055186512413 no 2137 0.375536862254599 2941 24208455 SGTC_894 0960-0238 55.9 µM -0.319290836229388 0.359673295001219 no 2138 0.374752990472673 3066 6741907 YDL195W SEC31 SGTC_3356 9151811 4.48 µM -0.319572040489167 0.359553824367125 no 2139 0.374646386097869 2961 1859254 YPR165W RHO1 SGTC_680 0417-1641 114 µM -0.319608787529213 0.3595382132697 no 2140 0.374632456023454 2936 2835990 SGTC_952 1185-0122 232 µM -0.319775064776656 0.359467577304987 no 2141 0.374569425660469 2928 678600 SGTC_2949 9072542 2.23 µM -0.319872383466754 0.359426237739349 no 2142 0.374532536825966 3069 16457352 SGTC_290 2043-6722 48.1 µM -0.320266189339508 0.359258971529939 no 2143 0.37438327568944 3057 773758 YLR208W SEC13 SGTC_2688 kanamycin b 96.69 µM -0.320451272457563 0.359180368122604 no 2144 0.374313131595001 3116 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_329 k048-0121 21.3 µM -0.320483091773108 0.359166855299105 no 2145 0.374301072907292 3035 6832902 SGTC_1359 1582-0056 520 nM -0.320638513858749 0.359100854173672 no 2146 0.374242173772517 3071 3661189 SGTC_207 4185-0010 4.486 µM -0.321716346758865 0.358643260346803 no 2147 0.373833796398677 3054 3761753 SGTC_2988 9073640 71.4286 µM -0.322355193494115 0.358372133744908 no 2148 0.373591812181052 3183 9102229 SGTC_3303 9125618 40.5795 µM -0.322733031203798 0.358211812978401 no 2149 0.373448717162754 3048 22695467 SGTC_370 0180-0345 38.7 µM -0.322929753627527 0.358128351346576 no 2150 0.373374221185307 2890 3989527 SGTC_1396 3511-0007 98.6 µM -0.324825396760355 0.35732445202982 no 2151 0.372656611049717 3077 X1396 SGTC_2173 5763948 167 µM -0.325039181125819 0.357233830564114 no 2152 0.372575709026074 2970 2867177 SGTC_393 acivicin 6.25 µM -0.325609316429948 0.356992194196458 no 2153 0.372359981268834 2960 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_129 0088-0017 176.636 µM -0.325796870083593 0.356912717205865 no 2154 0.372289023480462 3116 182446 SGTC_779 1360-0071 233 µM -0.326726845309436 0.35651872639626 no 2155 0.371937246997748 3180 7566 SGTC_3209 9113616 49.47 µM -0.327169737085528 0.35633114583407 no 2156 0.371769754374602 3188 16649353 SGTC_1413 3910-0535 34.4 µM -0.327728665564989 0.356094469175286 no 2157 0.371558413682317 3093 2876951 SGTC_431 k089-0097 107 µM -0.328734310396231 0.355668771414544 no 2158 0.371178259196316 3091 5499420 SGTC_1908 st060353 56.5 µM -0.329185098428487 0.355478007496347 no 2159 0.371007892789867 3191 4227716 SGTC_2472 5377652 49.4 µM -0.333349932417129 0.353717255998206 no 2160 0.369435075983274 3028 1610903 SGTC_1183 1254-0324 198 µM -0.333457315756232 0.353671899104308 no 2161 0.369394552261773 3128 5799357 SGTC_87 0100-0052 35.5 µM -0.333477984733532 0.353663169118623 no 2162 0.369386752485698 3098 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_35 0133-0054 64.071 µM -0.333510308723404 0.353649516542803 no 2163 0.369374554608105 3025 99677 SGTC_1565 sinapyl alcohol 95.1 µM -0.335537466274206 0.352793689503627 no 2164 0.368609843543918 3092 5280507 A phenol propionate derived from cinnamic acid. SGTC_236 1509-0011 5.31 µM -0.337366067700427 0.352022327426823 no 2165 0.36792048042646 3127 3107280 SGTC_1649 st011737 51.3 µM -0.337574857496971 0.351934291918244 no 2166 0.367841795917748 3061 1761035 SGTC_601 0986-0029 62.9 µM -0.338399797108558 0.351586536602247 no 2167 0.367530963502086 3018 24747981 SGTC_3317 9138495 8.753 µM -0.33917387030827 0.351260337054378 no 2168 0.367239376149203 3001 17020139 SGTC_1341 1486-1360 280 µM -0.339852819120625 0.350974313715089 no 2169 0.366983684421018 2989 3976547 SGTC_1388 3346-4487 254 µM -0.340243860688456 0.350809616452661 no 2170 0.36683644515989 3082 3345614 SGTC_736 0958-0254 92.6 µM -0.343211881565776 0.3495604734851 no 2171 0.365719533384897 3114 6812352 SGTC_2344 7990960 76.95 µM -0.343537391740466 0.349423575668795 no 2172 0.365597107954625 3029 140813 SGTC_66 0109-0187 42.4 µM -0.343815460248684 0.349306645612723 no 2173 0.365492536330303 2952 759417 SGTC_1518 st038567 90.8 µM -0.343884216096926 0.349277735427461 no 2174 0.365466681255235 3057 77966 SGTC_1646 st011709 75.6 µM -0.343958202598239 0.349246626854857 no 2175 0.36543885991865 3120 5757843 SGTC_2210 7115885 190.385 µM -0.344097932214175 0.349187878509969 no 2176 0.365386318958909 3028 2927039 SGTC_1390 3413-2614 145 µM -0.344203932129742 0.349143313993363 no 2177 0.365346462684962 3075 3421432 SGTC_2160 5660466 132.927 µM -0.344526816965823 0.349007579473862 no 2178 0.365225066018105 3098 2859134 SGTC_3020 9089140 49.47 µM -0.344885973681841 0.348856619654087 no 2179 0.365090047891487 3099 17217859 SGTC_1607 st000305 50.6 µM -0.346592919048141 0.348139488181293 no 2180 0.364448583166561 3153 5457690 SGTC_3240 9133527 49.47 µM -0.347116213827758 0.347919747208497 no 2181 0.364252006532783 3026 17617455 SGTC_708 3448-5400 146 µM -0.347298710091324 0.347843125722149 no 2182 0.364183459874654 3116 3462195 SGTC_1627 st003713 25.6 µM -0.347964876037074 0.347563487136135 no 2183 0.363933280958613 3102 16195070 YER133W GLC7 SGTC_1127 asiatic acid 681.4 nM -0.348484940200556 0.347345235790104 no 2184 0.363738010930768 3006 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2338 7999974 200 µM -0.348917305594781 0.347163826836532 no 2185 0.363575696355641 3059 315925 SGTC_13 0199-0087 65 µM -0.349835605747247 0.346778648858981 no 2186 0.363231037955254 3030 4589825 SGTC_663 1486-0733 13.9 µM -0.350707726738391 0.346412987132459 no 2187 0.362903814108124 3019 722445 YPR165W RHO1 SGTC_1515 3460-0031 42.1 µM -0.351521497710983 0.34607191936073 no 2188 0.362598573704997 3056 2876596 SGTC_3054 9094397 49.47 µM -0.35316653387157 0.345382833100263 no 2189 0.361981797736208 3048 2598354 SGTC_1027 k015-0025 8.67 µM -0.353171927997406 0.345380574405778 no 2190 0.361979775896654 2990 3598955 SGTC_809 3998-0021 90 µM -0.353549657964618 0.345222420381527 no 2191 0.361838203799979 3180 715485 SGTC_2721 ifenprodil 61.44 µM -0.353720996474913 0.345150690541795 no 2192 0.361773992854567 3155 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_270 tamoxifen 5.46 µM -0.357990902710272 0.343364922512877 no 2193 0.360175060796057 3241 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1522 st012842 45.6 µM -0.358400518925375 0.343193794972523 no 2194 0.360021801683103 2935 3491067 YOR116C RPO31 SGTC_2581 avocatin a 64 µM -0.358764643729411 0.343041699611502 no 2195 0.359885582203537 3058 6710728 A skin care supplement. SGTC_2171 5739187 198.077 µM -0.358865094696352 0.342999745597747 no 2196 0.359848006519932 2965 2262761 SGTC_2431 5490079 200 µM -0.358931527343157 0.342972000624702 no 2197 0.359823156810187 3081 5722345 SGTC_174 3553-0389 74.3 µM -0.359252727769794 0.342837866219172 no 2198 0.359703017354909 3171 738071 SGTC_544 k015-0020 52.4 µM -0.360034136444186 0.342511630002861 no 2199 0.359410802881929 3087 3008304 SGTC_2408 sulbentine 18.36 µM -0.360328864781558 0.342388612132186 no 2200 0.359300608033435 3045 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_930 2810-3379 265 µM -0.361605554829909 0.341855922456962 no 2201 0.358823406524429 3247 1015764 SGTC_137 0438-0332 85.389 µM -0.364123012103628 0.340806454514024 no 2202 0.35788307674198 3154 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2414 st077232 92.9 µM -0.364508618625441 0.340645812853774 no 2203 0.357739119556722 2982 729801 SGTC_208 k072-0098 12.366 µM -0.364739938930669 0.340549459890677 no 2204 0.35765277123356 3055 5948901 SGTC_1211 1056-0033 32.3 µM -0.367395045796375 0.339444261933352 no 2205 0.356662183248089 3187 6741922 SGTC_8 0354-0001 70 µM -0.367467732409078 0.339414025221837 no 2206 0.35663507831411 3082 4993152 SGTC_984 1492-0255 2.91 µM -0.368575276527768 0.338953428865147 no 2207 0.356222163278803 3168 1585198 SGTC_2198 6589944 200 µM -0.370738921597591 0.338054324665287 no 2208 0.355415998853217 3095 5290268 SGTC_1463 k081-0032 34.1 µM -0.37214839723415 0.337469112193925 no 2209 0.354891182066176 3114 977755 SGTC_2178 5812956 200 µM -0.372545025723981 0.337304503330053 no 2210 0.354743547440928 3010 5403383 SGTC_40 0327-0103 19.753 µM -0.373976552709158 0.336710649796468 no 2211 0.354210880389354 3065 409036 SGTC_3082 9117008 49.47 µM -0.374557745973748 0.336469664096335 no 2212 0.353994701372107 3092 41448529 SGTC_330 1488-0319 80.1 µM -0.375212207820466 0.336198378737573 no 2213 0.353751325908556 3136 6846614 SGTC_2026 5148700 152 µM -0.375300575630478 0.336161755337265 no 2214 0.353718469048595 3040 79838 SGTC_3222 9128301 49.47 µM -0.375601987991507 0.33603684886175 no 2215 0.353606406304627 3050 4911358 SGTC_396 dithiazanine 1.25 µM -0.376906826858511 0.335496327446331 no 2216 0.353121423927277 3064 10578 An antihelmenthic. SGTC_1838 st055369 84.5 µM -0.378107020890622 0.334999454893833 no 2217 0.352675546453113 3092 676036 SGTC_2458 5808907 16.39 µM -0.37984401978059 0.334280859928511 no 2218 0.352030601954895 3219 2731747 SGTC_381 3461-2219 42.7 µM -0.381333558258656 0.333665122342562 no 2219 0.351477877790085 3171 2883159 SGTC_625 k213-0058 121 µM -0.381555913967097 0.333573244475804 no 2220 0.351395394988041 3140 3655420 SGTC_923 1900-2434 73.3 µM -0.382900998215964 0.333017665686565 no 2221 0.350896585600072 3028 5910570 SGTC_2492 derrusnin 100 µM -0.383268353064403 0.332865995656308 no 2222 0.350760400798555 3003 1715307 Part of coumarin class of compounds. SGTC_2481 5478948 45.16 µM -0.383614967918858 0.332722913630572 no 2223 0.350631922251293 3223 77792 SGTC_2824 7998404 51.95 µM -0.385611934519091 0.331899044219621 no 2224 0.349892046565371 3050 837851 SGTC_2133 5320837 200 µM -0.385903667363486 0.33177875468725 no 2225 0.349784007228585 3227 2841355 SGTC_398 bronopol 33.3 µM -0.386314309328781 0.331609465016537 no 2226 0.349631952108151 3041 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_483 fpl-64176 144 µM -0.386457588139157 0.331550405538369 no 2227 0.349578903593252 3138 3423 SGTC_2984 9022109 38.96 µM -0.386915130483704 0.331361834780233 no 2228 0.349409519695017 3203 6459207 SGTC_2512 diallyl trisulfide 49.23 µM -0.387784254756178 0.33100375306698 no 2229 0.349087849214478 3151 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2490 carminic acid 95.39 µM -0.388355884402407 0.3307683242182 no 2230 0.348876343170283 3149 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_857 0438-0306 1.35 µM -0.390132927003384 0.330036867099783 no 2231 0.348219127944946 3183 4686136 SGTC_3112 9123419 49.47 µM -0.3916260624241 0.329422772170018 no 2232 0.34766726402415 3081 17015854 SGTC_1353 1498-1206 8.11 µM -0.392610110718188 0.32901830522204 no 2233 0.347303735374141 3140 6756808 SGTC_922 1866-0035 480 µM -0.39478600939972 0.328124670725934 no 2234 0.346500410454771 3091 3156169 SGTC_2732 terfenadine 20 µM -0.396005673709342 0.327624188074477 no 2235 0.346050421326731 3118 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1105 epirubicin 18.1 µM -0.39656121947796 0.327396325428245 no 2236 0.345845527450461 3085 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2056 5235370 200 µM -0.397472947857813 0.32702251029128 no 2237 0.345509365757969 3097 5511916 SGTC_1014 4130-3005 69.3 µM -0.398092670253361 0.326768518702708 no 2238 0.345280938571588 3088 743608 SGTC_1902 st060212 70.5 µM -0.400304412561 0.325862696939061 no 2239 0.344466159159879 3222 688944 SGTC_420 mitomycin C 81.9 mM -0.400374243351402 0.325834114349568 no 2240 0.344440446056692 3098 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1347 1493-0251 600 nM -0.400712472710879 0.325695687458981 no 2241 0.344315913371184 3224 3986378 SGTC_317 4495-0002 170 µM -0.401617190808523 0.325325532274809 no 2242 0.343982888149495 3149 15991618 SGTC_3352 9151559 45.5865 µM -0.401633966681823 0.32531867024146 no 2243 0.343976714120298 3156 17159339 SGTC_1669 st015249 58.4 µM -0.402434045856928 0.324991473222236 no 2244 0.343682309092453 3213 722793 SGTC_2196 6573537 42.6665 µM -0.402486638086349 0.324969970048735 no 2245 0.34366296005484 3225 2903087 SGTC_1886 st057356 49.9 µM -0.402627551680595 0.324912358147921 no 2246 0.343611119007531 3102 24207747 SGTC_2453 5731132 22.18 µM -0.402769260715286 0.324854425257313 no 2247 0.343558988289796 3259 1362040 SGTC_157 1348-1695 65.819 µM -0.402936614355401 0.324786013901937 no 2248 0.3434974274839 3172 5380510 SGTC_2821 7996764 71.43 µM -0.402995981017227 0.324761747228182 no 2249 0.34347559053654 3317 2987135 SGTC_1468 k284-1086 134 µM -0.403266375499227 0.324651230384242 no 2250 0.343376137451289 3147 15996457 SGTC_455 paf C-16 10 µM -0.403683826423523 0.324480638287335 no 2251 0.343222617217746 3100 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_363 0455-0021 3.06 µM -0.403997265266817 0.324352575122852 no 2252 0.343107365091123 3091 4597466 SGTC_2403 6032726 181.2 µM -0.404083293400358 0.324317429841102 no 2253 0.343075734916129 3168 2881040 SGTC_2274 7947094 46.08 µM -0.405075848242607 0.323912052270093 no 2254 0.342710879415828 3104 2971028 SGTC_2059 5238311 157 µM -0.405497643180055 0.323739846672522 no 2255 0.342555875240649 3059 703021 SGTC_2936 9038235 15.59 µM -0.405508754255157 0.323735310880137 no 2256 0.342551792422747 3080 4749415 SGTC_169 k015-0017 16.025 µM -0.411684564062904 0.321218273244817 no 2257 0.340285320179372 3345 1840002 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.414322579535621 0.320145602595156 no 2258 0.339318939871956 3083 6708514 SGTC_3109 9122853 49.47 µM -0.414364111523671 0.320128726828572 no 2259 0.339303733946424 3179 1234709 SGTC_2771 fluoxetine 41.05 µM -0.414842382227332 0.319934417065462 no 2260 0.339128645644239 3295 3386 A selective serotonin reuptake inhibitor. SGTC_2830 7992007 71.43 µM -0.416256453294818 0.319360203420523 no 2261 0.338611177045957 3009 1952075 SGTC_1697 st025554 27.742 µM -0.416574948590129 0.31923093132149 no 2262 0.338494668089581 3110 1269519 SGTC_2473 5854593 8.94 µM -0.416800534397244 0.319139382977337 no 2263 0.338412155759804 3064 2872951 SGTC_559 1550-0661 158 µM -0.416811584962627 0.319134898665747 no 2264 0.338408114003147 3206 5830875 SGTC_1728 st035614 33.7865 µM -0.417041607656615 0.319041561629546 no 2265 0.338323987172801 3177 15945546 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.417831345816399 0.318721194415899 no 2266 0.338035215508619 3130 16486 A toxic proline analog. SGTC_343 4130-2827 29.8 µM -0.4179637906708 0.318667479750712 no 2267 0.337986795717236 3166 1118244 SGTC_1746 st038117 42 µM -0.41842770812041 0.318479362284962 no 2268 0.337817215810303 3211 2898218 SGTC_1367 1812-0510 76.9 µM -0.419903308656469 0.317881320906814 no 2269 0.337278045303895 3186 1142582 YDR527W RBA50 SGTC_3324 9138759 60.749 µM -0.420030714589575 0.317829707208445 no 2270 0.337231508027537 3254 45595710 SGTC_1837 st055472 66.5 µM -0.420435592918402 0.317665709554709 no 2271 0.337083635572971 3312 676091 SGTC_1470 k295-0292 231 µM -0.422307334363956 0.316908018205967 no 2272 0.336400352709528 3253 5045612 SGTC_1051 3253-3903 78 µM -0.422628831998976 0.316777951296584 no 2273 0.336283043647224 3088 5509239 SGTC_2366 9070441 60.58 µM -0.425550220102567 0.315597097363999 no 2274 0.335217810073292 3147 6837235 SGTC_904 1141-0088 396 µM -0.42566350024234 0.315551346207027 no 2275 0.33517653103885 3178 1378119 SGTC_488 nitrendipine 139 µM -0.427134695250572 0.314957422484415 no 2276 0.334640611745287 3203 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1893 st059353 36.1 µM -0.427276525595861 0.314900190600001 no 2277 0.334588964299544 3210 3112488 SGTC_2586 curcumin 80 µM -0.42845094102791 0.314426457198156 no 2278 0.334161421871283 3244 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2836 9010338 19.48 µM -0.428675517285853 0.314335902829338 no 2279 0.334079690037126 3146 2994051 SGTC_2425 5628681 7.85 µM -0.429158605480352 0.314141148306215 no 2280 0.333903902556255 3219 5714958 SGTC_2628 lathosterol 100 µM -0.429173582311754 0.314135111300256 no 2281 0.333898453327246 3316 6710616 SGTC_3248 9135562 49.47 µM -0.431774366348051 0.313087517446252 no 2282 0.332952705896506 3211 17650701 SGTC_1780 st038448 24.544 µM -0.434154361719977 0.312130177144097 no 2283 0.332088175879048 3319 728868 YDL195W SEC31 SGTC_1432 4049-0298 68.4 µM -0.434658362408636 0.311927607971542 no 2284 0.331905212750542 3261 741646 SGTC_899 1083-0020 478 µM -0.435292251992114 0.311672914289745 no 2285 0.331675154054855 3320 767123 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.435938249737384 0.311413448265709 no 2286 0.331440766223394 3335 23847180 SGTC_2153 5569715 200 µM -0.436249063371723 0.311288642832492 no 2287 0.331328016997694 3228 2054701 SGTC_3097 9117246 49.47 µM -0.437040980005088 0.310970751303035 no 2288 0.331040814327767 3243 16423892 SGTC_1688 st021091 57.6 µM -0.438542245833637 0.3103684996491 no 2289 0.330496626445179 3285 3656366 SGTC_777 1315-0167 517 µM -0.439950277082414 0.309804111866803 no 2290 0.329986560260474 3234 4221767 SGTC_2135 5326629 150.42 µM -0.440538012999237 0.309568659375519 no 2291 0.32977374345498 3182 5020077 SGTC_1501 4491-0275 38.4 µM -0.440734339159873 0.309490026688582 no 2292 0.32970266681674 3265 5104718 SGTC_3031 9088762 49.47 µM -0.441334744227028 0.309249606173728 no 2293 0.329485338267446 3123 205253 SGTC_579 4491-1009 110 µM -0.441779105279017 0.309071723015962 no 2294 0.329324530025163 3315 1271041 SGTC_833 3852-0053 558 µM -0.442087356457137 0.308948352594049 no 2295 0.329212996643039 3326 3123681 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.442733162370152 0.308689953556623 no 2296 0.328979376366277 3275 1609 A potent and irreversible inhibitor of serine proteases. SGTC_845 0330-0138 4.51 µM -0.44312091099875 0.308534853557159 no 2297 0.328839140390201 3238 9039800 SGTC_1122 capsaicin 818.572 nM -0.443574092223384 0.308353623718063 no 2298 0.328675270123809 3288 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3138 9097216 49.47 µM -0.444366900543341 0.308036687323671 no 2299 0.328388669978531 3254 25237486 SGTC_2568 diosmetin 100 µM -0.44499094766446 0.307787316257916 no 2300 0.328163147990713 3347 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3267 9137951 49.47 µM -0.446823818949988 0.307055409010393 no 2301 0.327501135991071 3127 16643986 SGTC_834 0312-0008 75.7 µM -0.447033320106598 0.306971799292405 no 2302 0.327425501065697 3226 6385573 YIL048W NEO1 SGTC_1911 st060208 74.3 µM -0.447297468778091 0.306866394630324 no 2303 0.327330147177086 3265 688783 SGTC_1264 0783-0040 158 µM -0.448396531321902 0.306428001282234 no 2304 0.326933522347056 3123 2855798 SGTC_1272 0839-0021 27 µM -0.449569535345007 0.305960419666553 no 2305 0.326510429429865 3266 5027250 SGTC_2718 lomofungin 53.02 µM -0.450143901829811 0.30573158152121 no 2306 0.32630334147825 3319 5351222 A RNA synthesis inhibitor. SGTC_2249 haloperidol 116.36 µM -0.450392797248745 0.30563244056808 no 2307 0.326213618807628 3237 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_216 k038-0035 28.382 µM -0.451912121727577 0.305027566703158 no 2308 0.325666145770855 3267 4444231 YPR107C YTH1 SGTC_1118 chelidonine 707.474 nM -0.451960427043656 0.305008344100339 no 2309 0.325648745602409 3298 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_3155 9099265 49.47 µM -0.452052392991042 0.304971748686426 no 2310 0.325615619388147 3280 25236499 SGTC_1583 clindamycin 39.6 µM -0.452123919110297 0.304943288109329 no 2311 0.325589856569792 3191 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_452 diindolylmethane 8 µM -0.452551657397662 0.304773113677752 no 2312 0.325435807951801 3282 3071 Inhibits expression of several cancer promoting factors. SGTC_2033 5192550 145 µM -0.452572603832003 0.304764781284203 no 2313 0.325428264924056 3207 182073 SGTC_2011 4012611 177 µM -0.453132222290083 0.304542205186089 no 2314 0.325226767010036 3178 2049887 SGTC_299 1273-0059 1.44 µM -0.453419774643453 0.304427865612278 no 2315 0.325123249907494 3273 2848077 SGTC_1243 0416-0003 5.65 µM -0.45383129873597 0.304264264347967 no 2316 0.324975127210528 3194 2141977 SGTC_835 0312-0010 67.2 µM -0.455052681542283 0.303778934765882 no 2317 0.324535669452004 3171 1626196 SGTC_1810 st050138 53 µM -0.455538982379051 0.303585794091851 no 2318 0.324360764665319 3299 3444541 SGTC_274 sirtinol 40.1 µM -0.456904475003371 0.303043764387049 no 2319 0.323869853683373 3236 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1962 st076595 64.5 µM -0.458453615278624 0.302429360913411 no 2320 0.32331328992833 3216 279619 SGTC_2238 6671620 73.2395 µM -0.458624588643702 0.302361585523591 no 2321 0.32325188806412 3182 729941 SGTC_2157 5649910 96.377 µM -0.459218480003077 0.302126214564298 no 2322 0.323038640583131 3186 2858091 SGTC_3094 9117742 49.47 µM -0.459674899954788 0.301945382177477 no 2323 0.322874794222728 3186 17149698 SGTC_311 1315-0136 58 µM -0.460617984785534 0.301571888564943 no 2324 0.322536353046216 3367 6759207 SGTC_1757 st041620 31.8375 µM -0.461098739332882 0.30138157345426 no 2325 0.322363883084288 3266 5289815 SGTC_1268 0828-0275 2.46 µM -0.461183050857321 0.301348202833368 no 2326 0.32233364039233 3303 745337 SGTC_122 0236-0016 402.397 µM -0.461307192250676 0.301299070522244 no 2327 0.322289112796846 3263 6808838 SGTC_1178 0988-0033 191 µM -0.46163540354219 0.301169189413709 no 2328 0.322171400772937 3306 5392207 SGTC_1481 3346-2004 36 µM -0.461697028820015 0.301144805620836 no 2329 0.322149301034794 3301 2770522 SGTC_2001 4023502 57.655 µM -0.46181086646277 0.301099764861067 no 2330 0.322108478822215 3279 108941 YCR052W RSC6 SGTC_3135 9127742 49.47 µM -0.462563314109687 0.300802129406073 no 2331 0.321838704863873 3231 3643468 SGTC_248 streptozotocin 5.23457 mM -0.463598161060513 0.30039300605949 no 2332 0.321467836061315 3292 5300 DNA alkylating agent. SGTC_3104 9120930 49.47 µM -0.465247202499906 0.299741583015639 no 2333 0.320877219732652 3309 17014836 SGTC_3036 9090181 49.47 µM -0.465634800482436 0.299588562577686 no 2334 0.320738464359967 3262 25236586 SGTC_1087 pterostilbene 9.05 µM -0.46577854137112 0.299531823877956 no 2335 0.320687013230794 3333 5281727 Similar to reservatol, lowers cholesterol. SGTC_1419 3993-2473 62.6 µM -0.465783645386944 0.299529809264349 no 2336 0.320685186344389 3268 704026 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.466500492286407 0.299246922594858 no 2337 0.320428647645953 3353 688801 SGTC_711 k292-0785 179 µM -0.467031888368575 0.299037297971075 no 2338 0.320238531766138 3230 4146315 SGTC_22 0964-0034 14.468 µM -0.467033939360453 0.299036489026923 no 2339 0.320237798080689 3271 138402 SGTC_3346 9158254 43.5805 µM -0.467092500320337 0.299013392062588 no 2340 0.320216849818301 3278 17639500 SGTC_1609 st001574 46.4 µM -0.46744185759288 0.298875619276848 no 2341 0.320091890621717 3207 3960012 SGTC_2722 naftopidil 47.16 µM -0.467814106536586 0.298728850660843 no 2342 0.319958765915259 3322 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.468051673777296 0.298635200862306 no 2343 0.319873818572099 3408 804 An inhibitor of viral and cellular DNA polymerases. SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.473160489321495 0.296624527845618 no 2344 0.318049341949522 3246 2374 Ca(2+)-ATPase inhibitor. SGTC_788 1182-0090 188 µM -0.473278348815962 0.296578215222593 no 2345 0.318007303429255 3400 5715185 SGTC_548 1436-0017 110 µM -0.473310042199323 0.296565761944126 no 2346 0.317995999326886 3380 9677137 SGTC_262 fenpropimorph 62.5 µM -0.474492779883551 0.296101200311031 no 2347 0.317574272721507 3281 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1256 0570-0116 285 µM -0.474592097421843 0.29606220507396 no 2348 0.31753887001125 3255 410638 SGTC_626 0214-0009 33 µM -0.475215509158128 0.295817487566773 no 2349 0.317316686906859 3355 3437874 SGTC_2971 9092186 9.93 µM -0.47654233371612 0.295296958058176 no 2350 0.316844027597765 3190 25236400 SGTC_2684 capsaicin 100 µM -0.476960881294155 0.295132844223721 no 2351 0.316694988900702 3354 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3032 9089427 49.47 µM -0.477275369948627 0.295009559865096 no 2352 0.316583023644421 3306 17173707 SGTC_235 0330-0087 5 mM -0.477406002375904 0.294958356932299 no 2353 0.316536520409352 3293 46494818 YHR062C RPP1 SGTC_1098 clofazimine 15.1 µM -0.477665012393535 0.294856846987092 no 2354 0.316444325204297 3356 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2095 5432005 200 µM -0.478607869504304 0.294487463087713 no 2355 0.316108809435878 3222 783734 SGTC_2044 5102272 200 µM -0.480377955023595 0.293794572716202 no 2356 0.315479333402561 3326 592666 SGTC_1473 k844-0725 134 µM -0.48056472265745 0.293721507552523 no 2357 0.31541294646216 3333 54682906 SGTC_659 k018-0002 107 µM -0.481120620765552 0.293504085035317 no 2358 0.315215386599978 3357 6797879 YHR007C ERG11 SGTC_812 4251-0442 148 µM -0.481140594125398 0.293496274454815 no 2359 0.31520828927809 3341 5723007 SGTC_303 1348-1668 34.2 µM -0.481890081621886 0.293203257047049 no 2360 0.314942016151563 3296 5380509 SGTC_1493 4348-0038 111 µM -0.481967962996037 0.293172816556819 no 2361 0.314914352467727 3348 800424 SGTC_912 3474-0017 2.18 µM -0.48214783213728 0.293102519021745 no 2362 0.314850466409858 3386 3360550 SGTC_119 0121-0043 24.815 µM -0.482313144704525 0.293037917469277 no 2363 0.314791755452719 3361 1092378 SGTC_3037 9091026 49.47 µM -0.482860547112519 0.292824048376967 no 2364 0.314597378248898 3347 25236398 YIL048W NEO1 SGTC_730 1436-0052 41.2 µM -0.485008206758691 0.29198566247105 no 2365 0.313835262023671 3332 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1316 1272-0050 65.9 µM -0.485449640068696 0.291813477893403 no 2366 0.313678713680873 3330 7340392 SGTC_2930 9013230 14.89 µM -0.485704398718703 0.291714128786419 no 2367 0.313588382241083 3344 2995857 SGTC_380 3970-0968 6 µM -0.486171560793132 0.291531988953862 no 2368 0.313422766572972 3204 2891601 SGTC_3250 9135583 49.47 µM -0.486820815138891 0.291278942049774 no 2369 0.313192659041693 3369 7699353 SGTC_577 r071-0003 38.6 µM -0.487685008954153 0.290942281617134 no 2370 0.312886485886124 3253 4568517 YMR134W ERG29 SGTC_872 0588-0139 234 µM -0.488270235686982 0.29071440055583 no 2371 0.312679220563235 3268 2047100 SGTC_415 dibenzyl ketone 100 µM -0.489508862149172 0.290232368092584 no 2372 0.312240740968932 3321 7593 SGTC_1847 st056231 15 µM -0.490039600266513 0.290025937016604 no 2373 0.312052938489162 3262 5393180 SGTC_860 0443-0016 25.1 µM -0.491270083207344 0.289547604515116 no 2374 0.31161771818982 3328 5337942 SGTC_1323 1348-1351 11.2 µM -0.491618588154463 0.289412195588845 no 2375 0.311494500192696 3266 6989654 SGTC_212 3807-4682 38.772 µM -0.491921301348054 0.289294602845093 no 2376 0.311387489535864 3341 3125501 YBL034C STU1 SGTC_3332 9141069 11.198 µM -0.493070183662442 0.288848509533019 no 2377 0.310981498839018 3219 17332883 SGTC_2880 9042983 58.44 µM -0.494504413467637 0.288292075000538 no 2378 0.310474995094362 3369 6464714 SGTC_419 nsc-638432 893 µM -0.496128128130829 0.28766273726066 no 2379 0.309902007489135 3301 368090 SGTC_2600 tangeritin 87.95 µM -0.496496325151369 0.287520117643744 no 2380 0.309772139725988 3292 68077 A bioactive flavone. SGTC_2383 9036125 200 µM -0.498267297467109 0.28683460628577 no 2381 0.309147827228043 3260 79580 SGTC_2232 chlorophetanol 41.5365 µM -0.498831085088447 0.286616536952012 no 2382 0.308949193328134 3375 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_971 1315-0384 26.7 µM -0.498942058137364 0.286573622572094 no 2383 0.308910101832904 3284 6769120 SGTC_1704 st028805 70.8 µM -0.499539353699632 0.286342694813455 no 2384 0.308699734988573 3333 2876101 SGTC_3231 9132313 49.47 µM -0.500539119807202 0.28595636078243 no 2385 0.308347758923755 3322 4905967 SGTC_3134 9127454 49.47 µM -0.502008475794887 0.285389015827794 no 2386 0.307830779450877 3421 24262820 SGTC_728 3030-5151 22.5 µM -0.503139238187743 0.284952773321796 no 2387 0.307433190551921 3324 3125388 SGTC_261 5-fluorouridine 15.376 µM -0.504288526315854 0.284509709839725 no 2388 0.307029319520117 3460 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_37 0566-0070 1.56 µM -0.504884693454323 0.284280010399032 no 2389 0.30681991273643 3324 1626686 SGTC_2653 dihydrofissinolide 100 µM -0.505539106759469 0.284027971183695 no 2390 0.306590119245884 3381 6857746 SGTC_2701 st077767 14.721 µM -0.505917090960786 0.283882443951309 no 2391 0.306457426880515 3328 5721188 SGTC_1060 3448-7350 82 µM -0.506215047027428 0.283767753413383 no 2392 0.306352846488292 3388 570178 SGTC_60 0986-0278 202 µM -0.506355332916933 0.283713761645345 no 2393 0.306303612631761 3228 3110598 SGTC_3285 9112818 20.8695 µM -0.508976033539 0.282706039272148 no 2394 0.305384511643673 3362 17017947 YPR165W RHO1 SGTC_91 0417-1751 58.384 µM -0.510016070817135 0.282306597210307 no 2395 0.305020101443865 3396 6795624 SGTC_691 1548-0686 185 µM -0.510352103659138 0.28217759677745 no 2396 0.304902402921361 3311 46495133 SGTC_3121 9125696 49.47 µM -0.511202383891365 0.281851307505493 no 2397 0.304604674799215 3366 1235365 SGTC_493 zm226600 134 µM -0.512158192532546 0.281484739618173 no 2398 0.304270150069605 3443 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2875 9039966 71.43 µM -0.513001371389673 0.281161558122322 no 2399 0.303975180696365 3333 6463691 SGTC_879 0831-1030 162 µM -0.513321488768258 0.281038907483716 no 2400 0.30386322739037 3397 1549252 SGTC_3143 9086658 49.47 µM -0.513346582346513 0.281029294154981 no 2401 0.303854452296052 3359 25236626 SGTC_2058 5236698 133 µM -0.514055592549197 0.280757738628909 no 2402 0.303606561833725 3294 766665 SGTC_2152 5568786 200 µM -0.514111786941386 0.280736221239227 no 2403 0.303586918512074 3344 5399883 SGTC_1037 k284-1091 78.7 µM -0.514731643498846 0.280498924955667 no 2404 0.303370279008809 3393 3334711 SGTC_914 3820-6779 408 µM -0.51520759860999 0.280316783589275 no 2405 0.303203979879584 3274 2893481 SGTC_3001 9076041 71.4286 µM -0.516511236996748 0.279818192912223 no 2406 0.302748696362839 3349 16004211 SGTC_2129 girgensonine 121.053 µM -0.517595177181711 0.279403956022214 no 2407 0.302370373705637 3322 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.519441903549134 0.278698900750719 no 2408 0.301726308195962 3299 390807 SGTC_1076 itraconazole 331 nM -0.519671005338876 0.278611493202253 no 2409 0.301646449528784 3388 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_105 0111-0055 734.78 µM -0.521060838015053 0.278081526728385 no 2410 0.301162195460281 3364 5179370 SGTC_3279 9140807 49.47 µM -0.521063115574848 0.278080658660451 no 2411 0.301161402186382 3378 45595718 SGTC_2570 licareol 100 µM -0.521347303964121 0.277972353622677 no 2412 0.301062426780904 3335 443158 SGTC_1154 4088-0362 150 µM -0.523781838963385 0.277045389537457 no 2413 0.30021514317576 3382 6618304 SGTC_2247 cerulenin 830 nM -0.525194577668218 0.276508175250636 no 2414 0.29972396698234 3493 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_312 4092-0653 6.84 µM -0.525991800144654 0.276205245490362 no 2415 0.299446952128233 3388 1148278 SGTC_253 dyclonine 31.25 µM -0.528765784176912 0.275152454081542 no 2416 0.298483968043622 3414 3180 An oral anasthetic. SGTC_2731 amoxapine 43.43 µM -0.529674148339512 0.274808138743767 no 2417 0.298168937400442 3411 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_293 4049-0273 38.5 µM -0.530190328423489 0.274612575422737 no 2418 0.297989988002158 3340 1380311 SGTC_1772 st048439 82.2 µM -0.530206120986923 0.274606593232558 no 2419 0.297984513805431 3387 2927068 YDL195W SEC31 SGTC_1647 st011722 22.4 µM -0.530283435612127 0.274577307541047 no 2420 0.297957714798221 3438 2854783 SGTC_14 0354-0009 295 µM -0.530299902518401 0.274571070307815 no 2421 0.297952007135973 3367 1713507 SGTC_1280 0880-0253 10.1 µM -0.531475797947434 0.274125852679781 no 2422 0.297544554101068 3356 6836607 SGTC_1362 1611-0397 101 µM -0.533036373545596 0.273535538680393 no 2423 0.297004200831248 3363 27816 SGTC_3217 9129673 49.47 µM -0.533257942511047 0.273451777521594 no 2424 0.2969275184159 3454 17248312 SGTC_456 gingerol 170 µM -0.534862519705433 0.272845567974314 no 2425 0.296372463644846 3482 442793 A herb. SGTC_2719 novobiocin 32.65 µM -0.534991256057818 0.272796960258474 no 2426 0.296327951831979 3452 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.535570111708053 0.272578451541312 no 2427 0.29612784489885 3435 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_785 1270-0111 65.3 µM -0.536040468814958 0.27240096328961 no 2428 0.295965290937936 3386 6741994 SGTC_1126 isoteolin 1.0172 µM -0.536688616353085 0.2721564802866 no 2429 0.295741360301353 3380 133323 SGTC_509 pifithrin 175 µM -0.536908270438595 0.272073650924286 no 2430 0.295665488950708 3460 4817 A p53 inhibitor. SGTC_2601 securinine 100 µM -0.538379855567094 0.271519054347147 no 2431 0.295157415385286 3297 442872 A GABA receptor antagonist. SGTC_2553 4-methylesculetin 85.09 µM -0.538920769709999 0.271315341540564 no 2432 0.294970762634297 3384 5319502 SGTC_470 aa-861 153 µM -0.542299714498003 0.270044529229098 no 2433 0.293806026134469 3379 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1213 1315-0166 115 µM -0.542407165077641 0.270004166259239 no 2434 0.293769022399332 3379 768401 SGTC_782 0083-0095 30.5 µM -0.545216217952456 0.268950039809191 no 2435 0.292802409303548 3432 3591729 An indicator and reagent. SGTC_1153 4055-0057 267 µM -0.545539176165482 0.268828978920598 no 2436 0.292691372024642 3351 882706 SGTC_2264 7948757 110.76 µM -0.546012187780483 0.268651719921126 no 2437 0.29252877972197 3314 2971411 SGTC_3123 9126162 49.47 µM -0.547361868525888 0.268146256156092 no 2438 0.292065073402908 3405 25239884 SGTC_197 4544-0043 41.561 µM -0.547952991637142 0.267925027717877 no 2439 0.291862090565227 3423 896523 SGTC_980 1473-0395 201 µM -0.548141139617587 0.267854632430199 no 2440 0.291797497151175 3378 768876 SGTC_2342 7990637 118.86 µM -0.5488370547625 0.267594337797677 no 2441 0.291558639196703 3453 2033102 YER133W GLC7 SGTC_2529 gangaleoidin 93.61 µM -0.550517207275902 0.266966432768174 no 2442 0.290982338964944 3377 4565183 SGTC_726 3448-4391 34.2 µM -0.551813272574919 0.266482577408333 no 2443 0.290538146424579 3541 1356692 SGTC_2686 alizarin 95.37 µM -0.552814397014989 0.266109135139598 no 2444 0.290195254523921 3368 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1254 0550-0035 264 µM -0.55437498155583 0.265527530497872 no 2445 0.289661122207331 3453 15121435 SGTC_562 3772-2733 112 µM -0.554592319791741 0.265446583234508 no 2446 0.289586771719298 3468 2876874 YIL048W NEO1 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.554637336932009 0.265429818241228 no 2447 0.289571372666901 3385 15053 SGTC_1356 1502-0781 85.8 µM -0.555885472389773 0.264965209739175 no 2448 0.289144575069081 3379 567702 SGTC_3276 9139060 49.47 µM -0.556061562841101 0.26489969474795 no 2449 0.289084385083815 3458 4870619 SGTC_1789 tunicamycin 25 nM -0.556266273021049 0.264823542049515 no 2450 0.28901441991455 3470 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.556387826410085 0.264778329151733 no 2451 0.28897287956823 3439 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3189 9110682 49.47 µM -0.556812937832254 0.264620235930077 no 2452 0.288827621669676 3436 17122418 SGTC_3180 9109287 49.47 µM -0.557530376236511 0.264353539172114 no 2453 0.288582555459285 3461 18891271 SGTC_1978 st071761 42 µM -0.557538707157554 0.264350443083466 no 2454 0.288579710316929 3362 5147680 SGTC_729 4092-0585 94.1 µM -0.557978971757831 0.264186850201629 no 2455 0.288429371742985 3372 2169061 SGTC_1597 7-benzyloxygramine 47.5 µM -0.560086325997539 0.263404517322198 no 2456 0.287710278442772 3455 260807 SGTC_2969 9091408 28.7 µM -0.561075114134208 0.263037848323526 no 2457 0.28737316612704 3325 4286311 SGTC_1164 k060-0068 93.7 µM -0.561287552982563 0.262959104393096 no 2458 0.287300762717205 3476 5963676 SGTC_2882 9058044 58.44 µM -0.561826345986924 0.262759446014892 no 2459 0.287117169999136 3419 18076804 SGTC_743 1275-0778 158 µM -0.562493237233146 0.26251242621251 no 2460 0.286890004999984 3447 2849257 YMR203W TOM40 SGTC_3247 9135149 49.47 µM -0.563879553920094 0.261999308343366 no 2461 0.286418052852713 3423 8934436 YOR116C RPO31 SGTC_756 0508-1999 28.3 µM -0.564033367311186 0.261942409045731 no 2462 0.286365711950061 3358 6753853 SGTC_3223 9129970 49.47 µM -0.565062920321151 0.261561715667564 no 2463 0.28601548402763 3459 17248386 SGTC_3122 9126309 49.47 µM -0.567904998871078 0.260512288645879 no 2464 0.285049738715669 3482 17591206 SGTC_947 3447-0010 211 µM -0.567962990945591 0.260490897878687 no 2465 0.285030049061862 3472 748350 SGTC_2991 9074669 71.4286 µM -0.567981016319111 0.260484249282541 no 2466 0.285023929161758 3492 17333109 SGTC_1116 jasmonic acid  1.58368 µM -0.568522837454709 0.260284441245213 no 2467 0.284840001549022 3511 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1070 indatraline 8.81 µM -0.568919034673954 0.260138385117996 no 2468 0.284705543556569 3429 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3288 9119690 36.221 µM -0.568946435850271 0.260128285373305 no 2469 0.284696245502095 3406 17595618 YKL019W RAM2 SGTC_2610 ononetin 44.17 µM -0.569130672609921 0.26006038316403 no 2470 0.284633732116993 3431 259632 SGTC_3312 9133330 71.43 µM -0.570800223830499 0.259445471098475 no 2471 0.284067535599833 3507 17617324 SGTC_1025 k007-0731 70 µM -0.571015870575762 0.259366101091465 no 2472 0.283994442417564 3361 6256118 SGTC_2364 9055074 200 µM -0.57155380512631 0.259168165921191 no 2473 0.283812149437161 3443 6470630 SGTC_2912 7964298 10.93 µM -0.572584806738338 0.258789023116753 no 2474 0.283462924637768 3475 2975850 SGTC_2006 4011487 200 µM -0.573618426033405 0.258409206018177 no 2475 0.283113020051648 3523 45595294 SGTC_2621 lithochol-11-enic acid 100 µM -0.573746291554302 0.258362240220461 no 2476 0.283069748957711 3498 6708711 SGTC_2868 9035608 32.47 µM -0.573830827628604 0.258331192025718 no 2477 0.283041142766534 3472 6462614 SGTC_674 0498-0004 451 µM -0.574037363440812 0.258255344210256 no 2478 0.282971258879041 3429 4231473 SGTC_341 1486-1430 230 µM -0.574109247427278 0.25822894838101 no 2479 0.282946938007155 3410 2054753 YPL210C SRP72 SGTC_583 1488-1091 88.9 µM -0.574207145958152 0.258193002249713 no 2480 0.282913817117453 3520 4303273 SGTC_1077 5-fluorocytosine 377 nM -0.574434133473069 0.25810966753748 no 2481 0.282837030192139 3463 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2301 7769476 200 µM -0.575754119753458 0.257625332926494 no 2482 0.282390694468312 3441 977820 SGTC_693 4161-2696 114 µM -0.576454267246705 0.257368623705691 no 2483 0.282154086542503 3457 805759 SGTC_2817 7995342 71.43 µM -0.57707148900939 0.257142429511522 no 2484 0.281945581728937 3349 18879975 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.577084089860958 0.257137812735328 no 2485 0.28194132578544 3414 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2147 5545932 89.7195 µM -0.577467745187166 0.256997267413996 no 2486 0.281811760837781 3456 797404 SGTC_1324 1418-0026 34.4 µM -0.577675700305181 0.256921103450475 no 2487 0.281741543925635 3482 1372513 SGTC_476 mead acid 10 µM -0.578198363007581 0.256729729093396 no 2488 0.281565101930931 3463 5312531 An omega 9 fatty acid. SGTC_1082 camptothecin 424.86 nM -0.579185803846765 0.256368377617811 no 2489 0.281231904312948 3358 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3098 9119039 49.47 µM -0.580087847786897 0.256038508737821 no 2490 0.280927689141347 3492 17161528 SGTC_2319 6033012 152.6 µM -0.580434149970691 0.255911928168128 no 2491 0.280810940669479 3375 847246 SGTC_2417 cerulenin 830 nM -0.582343052181869 0.255214771716968 no 2492 0.280167815988324 3544 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_316 k060-0003 58.6 µM -0.583363811470058 0.254842384759643 no 2493 0.279824206980368 3516 6152314 SGTC_2419 paclitaxel 166.5 µM -0.583964495316775 0.254623380073876 no 2494 0.279622099773106 3437 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.584478795837038 0.254435948441363 no 2495 0.279449113584212 3485 688669 SGTC_949 1165-0505 146 µM -0.584558708271284 0.254406831652806 no 2496 0.279422239515208 3457 6244267 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.585013618743108 0.254241114347323 no 2497 0.279269279787833 3405 641818 YHR062C RPP1 SGTC_3203 9113543 49.47 µM -0.585110490589314 0.254205832645865 no 2498 0.279236712719809 3488 17018012 SGTC_2089 5281248 129.67 µM -0.585579120905634 0.254035189027141 no 2499 0.279079191306038 3515 2737878 SGTC_977 1348-1378 135 µM -0.58584936876161 0.253936810275868 no 2500 0.278988372134873 3471 X977 SGTC_2242 6630449 61.2675 µM -0.585877155910388 0.253926696010159 no 2501 0.278979034833994 3482 691249 YDR170C SEC7 SGTC_70 0141-0289 43.283 µM -0.585895255227315 0.253920108139539 no 2502 0.27897295301187 3439 352408 SGTC_1884 5633444 25 µM -0.586793975664977 0.253593100681028 no 2503 0.278671041654258 3523 5724239 SGTC_958 1222-0007 33 µM -0.588055052650888 0.253134619818214 no 2504 0.278247670584041 3560 7312461 SGTC_126 0417-1624 672.48 µM -0.588691672144625 0.252903334272131 no 2505 0.278034062706776 3589 41912 YDL195W SEC31 SGTC_2857 9024691 58.44 µM -0.588900027761174 0.252827662290493 no 2506 0.277964169566796 3486 16478292 SGTC_1415 3966-0071 78.1 µM -0.590807591979284 0.252135414893768 no 2507 0.277324673776543 3504 2893185 SGTC_2070 5230947 200 µM -0.591002921966733 0.252064586895679 no 2508 0.277259231575512 3561 2835538 SGTC_3298 9116858 71.43 µM -0.591175801060714 0.252001908503626 no 2509 0.277201317490423 3518 2506942 SGTC_42 0133-0086 60.653 µM -0.591800607800998 0.251775449518577 no 2510 0.276992058077051 3461 162923 Model of phenazepam hydroxylation. SGTC_2802 7925815 54.55 µM -0.592172351398096 0.251640763372705 no 2511 0.276867590926691 3448 1262923 SGTC_1028 k015-0029 4.8 µM -0.592388822487 0.251562351429993 no 2512 0.276795124721444 3510 4588309 SGTC_315 k915-0449 187 µM -0.592457704712359 0.251537403049948 no 2513 0.276772067547099 3501 20970215 YNL149C PGA2 SGTC_2957 9076800 11.52 µM -0.594937825129374 0.250640002453363 no 2514 0.275942516061421 3426 16459615 SGTC_2113 5491891 107.031 µM -0.595549139787737 0.250419066684639 no 2515 0.275738231103688 3496 789979 SGTC_2556 citropten 84.59 µM -0.596518458636945 0.250068956012229 no 2516 0.275414463202682 3441 2775 A potential DNA crosslinker. SGTC_3273 9137859 49.47 µM -0.596767756906759 0.249978953355215 no 2517 0.275331223867359 3554 2377234 SGTC_2942 9052777 62.25 µM -0.596953467318887 0.249911918614328 no 2518 0.275269224219388 3564 6469503 SGTC_1856 st057054 55.7 µM -0.597048974049583 0.249877447854867 no 2519 0.275237341856758 3601 1266018 SGTC_1809 st050081 57.6 µM -0.597566432790933 0.249690727987156 no 2520 0.275064633735645 3581 5036894 SGTC_2611 pyromycin 23.93 µM -0.599205195480683 0.249099885954159 no 2521 0.274518029303361 3461 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_232 clozapine 119 µM -0.59992039348657 0.248842260675883 no 2522 0.274279645232394 3490 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2677 mitomycin C 100 µM -0.600362279806938 0.248683157372689 no 2523 0.274132410327345 3515 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_540 1187-0821 17.3 µM -0.600819004156341 0.248518768519413 no 2524 0.273980272489728 3474 847520 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.602639408814593 0.247864125754385 no 2525 0.273374298869103 3590 688664 SGTC_2448 5185112 27.17 µM -0.603736013107615 0.247470216351419 no 2526 0.273009583439199 3516 5718189 SGTC_837 0091-0265 12.5 µM -0.604871903143842 0.247062548154231 no 2527 0.272632056627225 3476 759367 SGTC_485 niflumic acid 177 µM -0.605200150244639 0.246944808006782 no 2528 0.272523008006116 3537 4488 A COX2 inhibitor. SGTC_1684 st024538 14.6195 µM -0.605791799239646 0.246732663134422 no 2529 0.272326508028962 3476 6732859 SGTC_1467 k284-1082 293 µM -0.606259417956935 0.246565060299746 no 2530 0.272171251123553 3521 3334705 SGTC_1471 k673-0312 37 µM -0.606518699171069 0.246472155608421 no 2531 0.272085184571214 3515 24099884 SGTC_2782 7736369 71.43 µM -0.607360419501017 0.246170682806784 no 2532 0.271805874803861 3527 2950836 YOL077C BRX1 SGTC_924 2046-0044 21.3 µM -0.609217906437604 0.245506100629539 no 2533 0.271190006426794 3547 3623589 SGTC_529 4076-0302 30.3 µM -0.611763008196053 0.244597067201926 no 2534 0.270347283768536 3486 5816522 SGTC_2485 5633444 17.78 µM -0.612248189482403 0.244423981070357 no 2535 0.270186781409333 3513 5724239 SGTC_2537 larixol 68.93 µM -0.612305609544525 0.244403501102909 no 2536 0.270167789487493 3553 6708759 SGTC_574 1315-0397 40 µM -0.612818138136043 0.244220738911584 no 2537 0.269998298130709 3581 6794277 SGTC_127 0180-0333 59.125 µM -0.614909493408656 0.243475748424688 no 2538 0.269307246491799 3539 771601 SGTC_2072 5231554 129 µM -0.615783222069362 0.243164869477356 no 2539 0.269018801110732 3615 789545 SGTC_2683 piperine 63.03 µM -0.615847747193049 0.243141919486894 no 2540 0.268997505483154 3482 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3102 9121669 49.47 µM -0.617864958768787 0.242425038205282 no 2541 0.268332179639997 3516 41905072 SGTC_2725 haloperidol 53.21 µM -0.618087102687964 0.242346162243062 no 2542 0.26825896175405 3517 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2296 7971656 126.45 µM -0.622295743414114 0.240854443752336 no 2543 0.266873709799563 3526 666570 SGTC_1172 0370-0043 85 µM -0.624874367456075 0.239942945232075 no 2544 0.266026758364537 3584 376585 SGTC_2079 5212404 121 µM -0.626243486248768 0.239459751328392 no 2545 0.265577624030187 3577 758462 SGTC_1942 st076330 65.2 µM -0.626507719054955 0.239366558624979 no 2546 0.265490987736505 3609 24208414 SGTC_1093 fluphenazine 7.97 µM -0.627448016572241 0.23903508428232 no 2547 0.265182800609404 3602 6602611 An atypical antipsychotic. SGTC_1155 4088-0394 48.2 µM -0.628278016826903 0.238742700645277 no 2548 0.264910914986685 3510 2326248 SGTC_2353 9059630 146.67 µM -0.628338451368814 0.238721419054213 no 2549 0.264891123800912 3557 4779114 SGTC_993 3909-8757 62.7 µM -0.628741129883859 0.238579645200918 no 2550 0.264759273282756 3515 4288324 YLR208W SEC13 SGTC_2023 5144124 124 µM -0.630271414465867 0.238041287739814 no 2551 0.264258511085143 3537 2830192 SGTC_2702 st077768 96.8 µM -0.630708842428882 0.237887522085598 no 2552 0.264115458170078 3497 6484119 SGTC_90 0870-0863 4.608 µM -0.631380697892715 0.237651456059391 no 2553 0.263895816831171 3551 1738164 SGTC_1150 3909-7983 10.9 µM -0.634104159453392 0.236695846713738 no 2554 0.26300642421702 3540 23965914 SGTC_2517 totarol 10 µM -0.636166529905268 0.235973609909556 no 2555 0.262333942978445 3537 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1363 1636-0063 10.4 µM -0.636326245812612 0.235917728525309 no 2556 0.262281900858427 3597 6072185 SGTC_566 0958-0068 16.5 µM -0.636849177333488 0.235734816347875 no 2557 0.262111544916701 3574 6815365 SGTC_516 3992-2719 87.3 µM -0.638251594035657 0.235244662152876 no 2558 0.261654958303945 3513 5350887 YDR037W KRS1 SGTC_3167 9103034 49.47 µM -0.63925148319431 0.234895537992361 no 2559 0.261329672527017 3578 5127859 SGTC_384 k007-0144 5.16 µM -0.640322077743284 0.234522043783247 no 2560 0.260981615163897 3584 6824886 SGTC_2835 9006588 71.43 µM -0.640524465235625 0.234451474576378 no 2561 0.260915844452663 3604 2345538 SGTC_2216 7189485 200 µM -0.640867916790142 0.234331745529887 no 2562 0.260804251073003 3588 731273 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.642155067749547 0.233883339023337 no 2563 0.260386251912103 3605 279621 SGTC_1049 3226-0134 66 µM -0.643263679221169 0.233497511961381 no 2564 0.260026509824225 3613 5702385 SGTC_1131 3454-3128 32.3 µM -0.643912875587486 0.233271737896591 no 2565 0.259815966013262 3572 710982 SGTC_530 4358-1714 28 µM -0.644164458353517 0.233184276361908 no 2566 0.259734397722898 3579 1564641 SGTC_1091 telmisartan 47.6 µM -0.644464786411811 0.233079892600859 no 2567 0.259637042517327 3649 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_106 0092-0003 11.579 µM -0.645711621877934 0.232646812802497 no 2568 0.259233066292569 3539 1072148 SGTC_1925 st057770 10.1 µM -0.646016583253499 0.232540954670891 no 2569 0.259134307901192 3509 5989122 SGTC_1078 idebenone 36.1 µM -0.646350251720779 0.232425162427938 no 2570 0.25902627532137 3595 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3092 9117248 49.47 µM -0.646487673920747 0.232377482425715 no 2571 0.258981788603618 3610 17141857 SGTC_1964 st076914 61 µM -0.647428055406397 0.232051353739278 no 2572 0.258677471629936 3605 24208661 SGTC_1228 0124-0032 52.5 µM -0.647723086189416 0.231949088224183 no 2573 0.258582034843627 3608 X1228 SGTC_1111 tnp00062 510.699 nM -0.648612080440905 0.231641090973787 no 2574 0.258294572575912 3620 676306 SGTC_1983 st071813 46.9 µM -0.648924792937916 0.231532804116125 no 2575 0.258193494277254 3567 11838595 SGTC_2443 5493264 126.67 µM -0.6489488574926 0.231524472152075 no 2576 0.258185716722708 3581 5340055 SGTC_3079 9117512 49.47 µM -0.649031888296527 0.231495725358319 no 2577 0.25815888247731 3626 7185044 SGTC_2700 st077718 96.8 µM -0.650043075632486 0.231145793405227 no 2578 0.257832198761965 3576 904970 SGTC_2872 9044037 25.97 µM -0.653420941848144 0.229978989971041 no 2579 0.256742470787148 3590 6465195 SGTC_520 3584-0023 682 µM -0.65619618275087 0.229022820998133 no 2580 0.255848952330413 3545 1340790 SGTC_2923 7992654 58.14 µM -0.656240584085782 0.229007541311521 no 2581 0.255834670048843 3614 2985126 SGTC_1782 st039423 80.636 µM -0.658373845597026 0.228274103182427 no 2582 0.255148968628771 3566 2068169 SGTC_1885 st057546 99.9 µM -0.658417801317846 0.228259004631399 no 2583 0.255134849906761 3651 702008 SGTC_657 3534-0529 86.7 µM -0.658998979651647 0.228059425821878 no 2584 0.254948211938908 3639 1049549 SGTC_929 2805-0021 398 µM -0.659586996587044 0.227857598528525 no 2585 0.254759450576267 3627 3098024 SGTC_1423 4048-0112 5.59 µM -0.660083814147331 0.227687152303089 no 2586 0.254600022489054 3612 X1423 SGTC_2214 7179297 48.276 µM -0.660237719397673 0.227634365656347 no 2587 0.254550645105193 3622 769744 SGTC_2856 9022925 19.48 µM -0.660574626883376 0.227518836689732 no 2588 0.254442572672339 3603 4944862 SGTC_2258 7960471 200 µM -0.661329379040285 0.227260144464364 no 2589 0.254200552251874 3559 2974708 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.661700300411501 0.227133071482371 no 2590 0.254081656077895 3622 6708561 SGTC_666 0272-0154 136 µM -0.661890213720054 0.22706802508587 no 2591 0.254020792028281 3628 6870312 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.662103091373569 0.226995125755536 no 2592 0.253952577382741 3607 688664 SGTC_1513 0337-0559 19 µM -0.662126498127596 0.226987110986453 no 2593 0.253945077494792 3525 775073 SGTC_1152 3909-8331 15.9 µM -0.663549694420416 0.226500090481645 no 2594 0.253489281750458 3607 16001939 SGTC_2580 diallyl disulphide 81.36 µM -0.663768881805268 0.226425136601635 no 2595 0.253419122571688 3622 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_233 rapamycin 362 pM -0.664925811053674 0.226029742277715 no 2596 0.253048972948198 3632 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1953 st076800 12.1 µM -0.665211841310553 0.225932048246561 no 2597 0.252957503886497 3586 297591 SGTC_2195 6536160 144.242 µM -0.667515344582209 0.225146154398359 no 2598 0.25222150579213 3521 3834386 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.667730334060472 0.225072884825137 no 2599 0.252152871628247 3676 5024745 SGTC_2036 5160441 105 µM -0.669709422289344 0.224399035861705 no 2600 0.251521522018345 3640 134534 YIL048W NEO1 SGTC_560 2332-1943 155 µM -0.669944346331308 0.224319123953074 no 2601 0.251446634317133 3623 21177716 SGTC_2374 9071832 200 µM -0.670554063950022 0.224111797420114 no 2602 0.251252327121443 3596 17381698 SGTC_2705 st078069 42.8 µM -0.671884582474564 0.223659750026202 no 2603 0.250828588100258 3610 1530061 SGTC_842 0271-0008 11.1 µM -0.671918324174205 0.223648292934136 no 2604 0.250817847079407 3675 1221709 SGTC_3232 9132874 49.47 µM -0.672098207834273 0.22358721854757 no 2605 0.250760588687213 3606 3784940 SGTC_2728 chlorpromazine 9.18 µM -0.672668406144044 0.223393686608288 no 2606 0.250579135805373 3631 2726 A thorazine and dopamine antagonist. SGTC_2367 9070478 135.38 µM -0.672879679201116 0.223322002283464 no 2607 0.250511920537937 3608 572802 SGTC_18 0111-0177 500 nM -0.673289058906926 0.223183138221587 no 2608 0.250381706013226 3708 721752 SGTC_1511 0906-3109 28.5 µM -0.673678964221427 0.223050925706751 no 2609 0.250257719222598 3677 2882180 SGTC_823 0417-1665 178 µM -0.673968875334 0.222952649020959 no 2610 0.250165550900346 3652 3429856 SGTC_1676 st018489 23.4 µM -0.674427061088624 0.222797379383021 no 2611 0.25001992155087 3642 3696235 SGTC_830 4076-0286 57.8 µM -0.67754861309354 0.221741191501447 no 2612 0.249028968593874 3686 6866659 SGTC_2895 9054447 58.44 µM -0.678024638455596 0.221580378424777 no 2613 0.248878035712906 3678 2697450 SGTC_3272 9137413 49.47 µM -0.679658710668186 0.221028856046193 no 2614 0.248360292772293 3605 17614870 SGTC_1909 st060837 51.5 µM -0.681799924305539 0.220307356902503 no 2615 0.247682736078611 3622 678937 SGTC_1745 st081495 74 µM -0.682198043717301 0.220173356390625 no 2616 0.247556865761707 3598 13842402 YBL026W LSM2 SGTC_3275 9138069 49.47 µM -0.682591750538832 0.220040887065786 no 2617 0.247432424154178 3675 17617007 SGTC_569 4130-2812 160 µM -0.684530161148343 0.219389343126489 no 2618 0.246820225250307 3564 743552 SGTC_3165 9101544 49.47 µM -0.68581344167621 0.218958613878585 no 2619 0.24641537946308 3642 5002184 SGTC_447 ml7 120 µM -0.686529703143845 0.218718414540417 no 2620 0.246189570121781 3685 4216 Selective myosin light chain kinase inhibitor. SGTC_1370 2001-0092 44.6 µM -0.687170149230836 0.218503768484658 no 2621 0.24598775642237 3732 790957 SGTC_1147 3809-1045 12.3 µM -0.688978210328476 0.217898450278014 no 2622 0.245418489922413 3618 325925 SGTC_828 2074-0507 139 µM -0.689246046174799 0.217808864203534 no 2623 0.245334222277565 3699 X828 SGTC_1718 roemerine 11.9335 µM -0.689385019439331 0.21776238862214 no 2624 0.245290504051498 3599 235224 An aporphine alkaloid with mutagenic activity. SGTC_3063 1327-0034 4 µM -0.689564261301792 0.217702454823132 no 2625 0.245234124309645 3589 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3182 9108849 49.47 µM -0.690059747485673 0.217536826705185 no 2626 0.245078307560636 3681 17133045 SGTC_1689 st020265 53.493 µM -0.690944347347681 0.21724130892999 no 2627 0.244800257736697 3664 5758320 YPR016C TIF6 SGTC_630 4356-0227 183 µM -0.691631771794188 0.217011821629558 no 2628 0.244584301928867 3667 779312 SGTC_1015 4130-4525 82 µM -0.691853585955303 0.216937801896663 no 2629 0.244514640455326 3659 1363237 SGTC_2330 7979373 200 µM -0.692016129740343 0.216883570047365 no 2630 0.244463599826749 3629 1863007 SGTC_814 3342-0569 96 µM -0.693789753958527 0.216292319520853 no 2631 0.243907034546833 3711 4346283 SGTC_928 2764-0428 58.7 µM -0.693906210338176 0.216253530612796 no 2632 0.243870514339439 3687 662578 SGTC_460 trequinsin 123 µM -0.694266862635493 0.216133431283555 no 2633 0.243757434090668 3712 5537 A vasodilator. SGTC_2733 amorolfine 100 µM -0.694947615139436 0.215906842008044 no 2634 0.243544065603352 3666 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1032 k061-1018 98.7 µM -0.69532782677396 0.215780348047685 no 2635 0.243424939661449 3747 4005393 SGTC_2816 7982706 58.44 µM -0.695916270260929 0.215584661402146 no 2636 0.243240633677015 3671 2981853 SGTC_944 3370-0224 231 µM -0.696546739738021 0.215375113272289 no 2637 0.243043248497136 3683 4580514 SGTC_2734 clemastine 41.6 µM -0.696763061807232 0.21530324189105 no 2638 0.242975543106728 3652 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2018 5133068 143 µM -0.697155512588324 0.215172888603115 no 2639 0.242852738261602 3675 785362 SGTC_1545 lovastatin 49.4 µM -0.697807559502459 0.214956411274106 no 2640 0.242648775441126 3718 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2776 terbinafine 19.92 µM -0.698113418847664 0.214854910621694 no 2641 0.242553133409704 3683 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3254 9136651 49.47 µM -0.69868058844873 0.214666766811113 no 2642 0.24237583386385 3672 16454030 SGTC_2749 bexarotene 57.39 µM -0.701531816001689 0.213722397670634 no 2643 0.241485593188632 3684 82146 An retinoic acid receptor inhibitor. SGTC_3345 9148410 3.559 µM -0.702301012522059 0.213468043382238 no 2644 0.241245730982345 3635 4903596 SGTC_353 1988-1175 58.3 µM -0.702784754050672 0.213308172414479 no 2645 0.241094949908497 3553 2788357 SGTC_1329 1447-1697 50.6 µM -0.704373169692891 0.212783710657716 no 2646 0.240600205104125 3674 2840515 SGTC_1054 3429-0080 167 µM -0.705743244276538 0.212331945836576 no 2647 0.240173911488332 3696 1162877 SGTC_107 0358-0022 2.6945 µM -0.706142550706241 0.212200385138648 no 2648 0.240049746293848 3679 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_832 4083-0019 164 µM -0.706612995645037 0.212045447379183 no 2649 0.239903505343222 3764 1990758 SGTC_2459 5811157 9.22 µM -0.70691354602023 0.21194649785171 no 2650 0.239810102696508 3657 2870684 YBR192W RIM2 SGTC_1128 3448-9350 235 µM -0.707885546339367 0.211626673335316 no 2651 0.23950816807135 3723 619386 SGTC_1610 st001799 48.1 µM -0.70880999987693 0.211322755766733 no 2652 0.23922119569601 3621 621897 SGTC_3204 9114183 49.47 µM -0.70888427133489 0.211298349846816 no 2653 0.239198148224493 3704 17027248 SGTC_970 1315-0089 19.5 µM -0.70995996705695 0.21094505679826 no 2654 0.238864480892114 3644 6811083 YLR033W RSC58 SGTC_908 3448-7491 47.7 µM -0.710459602394609 0.210781078356466 no 2655 0.238709586893953 3724 1203031 SGTC_1266 0828-0227 32.9 µM -0.710656507685628 0.21071647532306 no 2656 0.238648558578264 3690 3913820 SGTC_1227 3909-8010 46.6 µM -0.711468320036355 0.210450248947188 no 2657 0.238397037752254 3677 15982272 SGTC_2726 cimetidine 79.27 µM -0.711862102949551 0.210321182616408 no 2658 0.238275085748839 3698 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_213 1246-0773 967 nM -0.713585675396892 0.20975681148946 no 2659 0.237741708928229 3667 6251622 SGTC_2031 5180455 200 µM -0.714523399281841 0.209450135051398 no 2660 0.237451796168954 3685 29949 SGTC_2019 4016004 108 µM -0.715998756637549 0.208968163530088 no 2661 0.236996058328838 3700 45595336 SGTC_1651 st011928 86.1 µM -0.718590191172091 0.208123173820303 no 2662 0.236196729408944 3701 720198 SGTC_3035 9091303 49.47 µM -0.719151231702721 0.207940501097159 no 2663 0.236023871994516 3745 25237002 SGTC_372 0155-0182 15.9 µM -0.719341745082464 0.207878492182287 no 2664 0.235965190399324 3688 771486 SGTC_1629 st005085 44.9 µM -0.720384043471837 0.207539434849308 no 2665 0.235644285859496 3703 24207091 SGTC_2777 climbazole 1.536 µM -0.722273322977142 0.206925690213124 no 2666 0.235063225475799 3674 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1740 st038286 13.222 µM -0.724541044182071 0.206190426588034 no 2667 0.234366819269518 3728 716786 SGTC_2142 5622915 118.518 µM -0.724879822345495 0.206080717613773 no 2668 0.234262880251029 3719 5322196 SGTC_2320 7373003 200 µM -0.725511583615417 0.205876222293384 no 2669 0.234069120568676 3750 5415828 SGTC_1742 st038235 28.8875 µM -0.725824726727047 0.205774905383817 no 2670 0.233973113229255 3729 564103 YBR002C RER2 SGTC_92 0063-0024 660.874 µM -0.726626416601594 0.205515654889116 no 2671 0.233727420544339 3790 3594437 SGTC_1011 4112-3381 17.4 µM -0.727097501463484 0.205363405954494 no 2672 0.233583114614272 3763 2877139 SGTC_3070 9117005 49.47 µM -0.728743041523877 0.204832113244623 no 2673 0.23307942946631 3749 8779016 SGTC_2943 9068529 45.32 µM -0.728858541165097 0.204794852797336 no 2674 0.233044098719707 3742 3270634 SGTC_1771 st048882 4.1505 µM -0.730330944636682 0.204320205426015 no 2675 0.232593958767467 3725 4580403 SGTC_364 0083-0097 67.7 µM -0.73045549749545 0.204280084347503 no 2676 0.232555902928334 3776 5207356 SGTC_1112 tnp00069 1.16933 µM -0.732152086489328 0.20373404486415 no 2677 0.232037872577389 3780 145826 SGTC_365 0121-0052 13.6 µM -0.733236113464226 0.203385611753771 no 2678 0.231707216369639 3752 3101739 SGTC_2060 5238662 140 µM -0.733386599408664 0.203337269965248 no 2679 0.231661335035027 3715 790130 SGTC_2987 9018338 71.43 µM -0.734102238255324 0.203107473493033 no 2680 0.231443214754437 3789 5055682 SGTC_3169 9102970 49.47 µM -0.735783212345549 0.20256831153116 no 2681 0.230931319651027 3788 17027839 SGTC_921 1561-0023 372 µM -0.736138083639247 0.2024545982432 no 2682 0.230823334082066 3717 24050882 SGTC_1796 st049173 110.4 µM -0.738541521969722 0.20168545688252 no 2683 0.230092722480785 3682 94134 SGTC_195 4234-0266 16.654 µM -0.738682075870276 0.201640531464992 no 2684 0.230050036146847 3736 2303354 SGTC_414 piperonyl butoxide 100 µM -0.740012277452149 0.201215654377208 no 2685 0.229646272334298 3725 5794 A potent inhibitor of cytochrome P450. SGTC_2381 9035592 200 µM -0.741021881963969 0.200893537180941 no 2686 0.229340086372506 3745 4749657 SGTC_2137 5261020 140 µM -0.742338897029262 0.20047380516342 no 2687 0.228941015241191 3717 763655 SGTC_2966 9084041 48.03 µM -0.742378137307639 0.200461307392698 no 2688 0.22892913095414 3701 17741380 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.743370727766113 0.200145329508103 no 2689 0.22862863076374 3688 140250 A respiratory chain inhibitor. SGTC_1820 st053765 18.6 µM -0.743688860621129 0.200044119555529 no 2690 0.228532365045513 3734 3690829 SGTC_172 1112-0046 2.638 µM -0.744192915848187 0.199883823756371 no 2691 0.228379886594835 3709 2802135 YIL048W NEO1 SGTC_1833 st055984 71 µM -0.744739313377683 0.199710149862146 no 2692 0.228214664045299 3791 676288 SGTC_1239 0337-0584 35.4 µM -0.746793304141696 0.199058096030503 no 2693 0.227594169018969 3798 914301 YML130C ERO1 SGTC_1062 mesoridazine 14.2 µM -0.747321218223383 0.198890713426275 no 2694 0.227434843765465 3753 4078 A neuroleptic. SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.747516101866592 0.19882894426428 no 2695 0.227376043473612 3723 61125 An anti-inflammatory. SGTC_1571 st070080 73.4 µM -0.747572128177227 0.198811188638036 no 2696 0.227359140800564 3804 4315245 SGTC_259 usnic acid 108.925 µM -0.749420330633572 0.198225999976943 no 2697 0.226801950462282 3821 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2271 7849410 118.62 µM -0.750743691421952 0.197807629232766 no 2698 0.226403461517833 3713 972430 SGTC_543 3844-1095 191 µM -0.751052496534323 0.197710079603144 no 2699 0.226310531392996 3770 4230703 SGTC_2844 9010103 25.97 µM -0.754149096482286 0.196733491107607 no 2700 0.225379849708534 3779 2480525 SGTC_526 4469-0568 170 µM -0.754511704935923 0.196619325063459 no 2701 0.225271009818919 3751 2901964 SGTC_51 1013-0126 23.419 µM -0.755844841043631 0.19619993682085 no 2702 0.22487111412646 3812 1627850 SGTC_1863 st057641 20.1 µM -0.757527897037526 0.195671243439974 no 2703 0.224366829547393 3784 3921635 SGTC_2674 ligustilide 100 µM -0.757663053981883 0.195628824538765 no 2704 0.224326361096988 3777 5319022 A signalling regulator. SGTC_495 decylubiquinone 155 µM -0.757919307768858 0.195548414817359 no 2705 0.224249645423342 3765 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3159 9100096 49.47 µM -0.759024762428907 0.195201764964373 no 2706 0.223918872033679 3734 25236875 SGTC_404 fumagillin 50 µM -0.759182670651279 0.195152278406693 no 2707 0.223871645483733 3760 12015870 A methionine aminopeptidase binder. SGTC_1202 1988-0068 29.6 µM -0.761125127495017 0.194544159531112 no 2708 0.22329116667782 3738 2850480 SGTC_3330 9141424 71.43 µM -0.761388902316139 0.194461669403011 no 2709 0.223212407002364 3837 27261020 SGTC_340 k038-0059 454 µM -0.762775628195306 0.194028349811291 no 2710 0.222798609177547 3772 23733424 SGTC_2104 5389443 200 µM -0.763289496664363 0.193867927373005 no 2711 0.222645382335297 3817 2244536 SGTC_925 2064-1272 59.6 µM -0.763916131321683 0.193672410368261 no 2712 0.222458611848763 3776 6815817 SGTC_1645 Cervolide 78 µM -0.765882028329153 0.193059809266606 no 2713 0.22187325011098 3759 23173 A fragrance. SGTC_1929 genistein trimethyl ether 50.5 µM -0.766960402186914 0.192724275903528 no 2714 0.221552529553875 3750 136420 SGTC_332 4112-0506 40.9 µM -0.766975674451846 0.192719526536349 no 2715 0.221547989313691 3755 2790355 SGTC_2395 5646831 180.19 µM -0.767472870291553 0.192564947696639 no 2716 0.221400208688388 3775 6808628 SGTC_2784 7567673 72.73 µM -0.769633756807195 0.191894006120702 no 2717 0.220758587468332 3790 3471247 SGTC_3115 9123671 49.47 µM -0.769696560590453 0.191874527367881 no 2718 0.220739955393422 3868 3286988 SGTC_1210 3013-0140 750 nM -0.770026434529773 0.191772236004782 no 2719 0.220642106079562 3832 905973 SGTC_2885 9057732 51.95 µM -0.771416942704409 0.191341417295289 no 2720 0.220229917885809 3798 6471414 SGTC_1134 3477-0009 42.5 µM -0.774253906878402 0.19046428719017 no 2721 0.219390327748123 3823 3973534 SGTC_401 neomycin 50 µM -0.774469872210573 0.19039761650171 no 2722 0.21932648894572 3780 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_553 k007-0256 45.7 µM -0.774831267203503 0.190286082266123 no 2723 0.219219685388266 3846 6287000 SGTC_1472 k841-0093 193 µM -0.776352392377898 0.189817070591523 no 2724 0.218770473058185 3885 X1472 SGTC_2760 etidronate 98.04 µM -0.77655899808639 0.189753422302595 no 2725 0.218709500010231 3800 3305 A chelator and antioxidant. SGTC_1358 1509-0022 2.48 µM -0.779538513289018 0.18883699369574 no 2726 0.21783127988854 3831 3258434 SGTC_346 4513-0042 7.16 µM -0.780064874257994 0.188675381403109 no 2727 0.217676345248374 3782 2827372 SGTC_2250 alverine citrate 130 µM -0.780175730108944 0.188641355427594 no 2728 0.217643722875387 3718 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1775 st081588 35.1725 µM -0.780248627062939 0.188618982576851 no 2729 0.217622272485973 3833 1426443 YGL099W LSG1 SGTC_1067 clotrimazole 1.36 µM -0.783091869813382 0.187747637720044 no 2730 0.216786582561585 3821 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2963 9082507 9 µM -0.783988377226876 0.187473408974492 no 2731 0.216523465126522 3839 16459611 SGTC_1852 st056254 31.4 µM -0.786361820152933 0.186748602904089 no 2732 0.215827772245284 3741 442583 SGTC_510 ag-490 170 µM -0.786604937274103 0.186674457444826 no 2733 0.215756584070458 3926 5328779 SGTC_441 propafenone 146 µM -0.786617279639036 0.18667069377686 no 2734 0.21575297041231 3775 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1699 st031318 29.054 µM -0.786718985025831 0.18663968163025 no 2735 0.215723193945995 3880 5340658 SGTC_251 melphalan 456.522 µM -0.78741765187717 0.186426729404462 no 2736 0.21551870841678 3861 460612 A DNA alkylator. SGTC_469 w7 172 µM -0.787481861369576 0.186407166036981 no 2737 0.215499921251032 3841 45115570 A P450 inhibitor. SGTC_1326 1431-2094 10.8 µM -0.788356657365768 0.186140759630432 no 2738 0.215244057830893 3796 616278 SGTC_2735 sertaconazole 140 nM -0.788801136197646 0.186005490519454 no 2739 0.215114122670873 3878 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2016 5121758 140 µM -0.789123819370613 0.185907325912101 no 2740 0.215019820753448 3788 2795203 SGTC_3141 9094609 49.47 µM -0.790008015433082 0.185638506113131 no 2741 0.214761543634293 3789 25236309 YDL196W YDL196W SGTC_3333 9141820 12.094 µM -0.791842064805432 0.185081674386841 no 2742 0.214226385769468 3827 1939433 SGTC_2265 7929201 200 µM -0.793061135234739 0.184712129732595 no 2743 0.213871102441297 3798 1265108 SGTC_948 3448-0295 75.3 µM -0.793720422753298 0.184512466929486 no 2744 0.213679104100448 3826 678569 SGTC_95 0471-0001 561.058 µM -0.793885103043005 0.184462615068867 no 2745 0.213631161426267 3780 4015405 SGTC_2468 5987765 72.9 µM -0.794264977422917 0.18434765181507 no 2746 0.213520594113732 3862 26772094 SGTC_1759 st043059 70 µM -0.794271369250654 0.184345717806205 no 2747 0.213518733975581 3836 669426 SGTC_2236 dapsone 200 µM -0.79545231008126 0.183988610991895 no 2748 0.213175220793342 3828 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1017 4239-0030 168 µM -0.795476563737127 0.183981281402285 no 2749 0.213168169246556 3880 1149593 SGTC_1963 st076565 50.3 µM -0.796581560891557 0.183647537976587 no 2750 0.212847044921729 3847 4914280 SGTC_2456 5770359 74.46 µM -0.797943133712588 0.183236819899121 no 2751 0.212451745459455 3811 3118787 SGTC_1144 3486-0183 12.5 µM -0.798538617551094 0.183057372554151 no 2752 0.212278996150439 3842 6744069 SGTC_1016 4226-1401 38 µM -0.799366822794147 0.182807977637073 no 2753 0.212038871123405 3810 2901613 SGTC_2727 riluzole 51.77 µM -0.802290805633899 0.181929184941592 no 2754 0.211192379846791 3843 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1527 coumarin 137 µM -0.802445025113617 0.181882908286048 no 2755 0.211147788442506 3946 323 A hepatotoxic, DNA x-linker. SGTC_3051 9093778 49.47 µM -0.803117585878077 0.181681178981307 no 2756 0.210953387058508 3860 17217378 SGTC_2854 9024559 71.43 µM -0.803939800836746 0.181434752348411 no 2757 0.210715871259344 3874 3163529 SGTC_1431 4049-0260 9.09 µM -0.804131568028331 0.181377307773104 no 2758 0.210660497442173 3816 3854841 SGTC_1485 3909-9022 254 µM -0.807815795789043 0.180275895383991 no 2759 0.209598315295027 3873 714516 SGTC_1179 1021-1431 9.29 µM -0.810096741308867 0.179596107253734 no 2760 0.208942288517621 3884 2840958 SGTC_3171 9103192 49.47 µM -0.810492338652837 0.179478371870801 no 2761 0.208828633269223 3870 13018434 SGTC_3013 9080133 71.4286 µM -0.810693019634559 0.179418664916021 no 2762 0.208770991485761 3902 17050193 SGTC_2907 7721985 69.9 µM -0.813008264586302 0.178730732516364 no 2763 0.208106659880904 3875 3267881 SGTC_3335 9143315 29.6265 µM -0.813152751095755 0.178687856133489 no 2764 0.208065242622924 3847 4899691 SGTC_2141 5621638 7.665 µM -0.814894261029128 0.178171572486797 no 2765 0.207566419243694 3894 2856238 SGTC_2350 9023895 38.85 µM -0.815222496839206 0.178074369938073 no 2766 0.207472481367897 3882 2997209 SGTC_128 0906-2981 13.371 µM -0.815729051965617 0.177924426185058 no 2767 0.207327559573261 3777 6740226 SGTC_256 clotrimazole 625 nM -0.8200285723565 0.176654946747467 no 2768 0.206099909520769 3801 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.820972655681885 0.17637696477153 no 2769 0.205830921927592 3899 5282309 SGTC_2475 5812728 15.03 µM -0.82161111816009 0.176189128721143 no 2770 0.205649129743738 3842 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2614 arthonioic acid 13.39 µM -0.8224169094499 0.175952245235402 no 2771 0.205419829397026 3793 6710684 SGTC_2926 9010726 65.15 µM -0.8229712610838 0.175789396185804 no 2772 0.2052621682821 3895 2994293 SGTC_1229 0139-0193 12.2 µM -0.824955041195492 0.175207413708639 no 2773 0.204698557884821 3899 3090752 SGTC_2818 7996756 12.99 µM -0.8266272724511 0.174717780771413 no 2774 0.20422417725913 3875 2241621 SGTC_3130 9127414 49.47 µM -0.827302661932266 0.174520271780303 no 2775 0.204032767691401 3868 1494646 SGTC_49 0717-0965 32.132 µM -0.827438268652233 0.17448063243501 no 2776 0.203994348794141 3910 5889349 YGL099W LSG1 SGTC_423 5-fluorouracil 457 µM -0.82853730338292 0.174159583429279 no 2777 0.203683139044791 3844 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_461 N-acetylfarnesylcysteine 136 µM -0.828670100520574 0.174120816292994 no 2778 0.203645554530856 3897 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2326 6164455 177.58 µM -0.830591307127722 0.173560577049329 no 2779 0.203102273588512 3879 2888790 SGTC_926 2268-1401 59.4 µM -0.831650807719731 0.173252109470815 no 2780 0.202803037372153 3846 2931578 SGTC_47 0149-0135 24.25 µM -0.834851184265529 0.172322459479636 no 2781 0.20190075143114 3907 5239155 SGTC_2779 methotrexate 400 µM -0.836084179719284 0.171965148003545 no 2782 0.201553773860527 3912 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1892 st058411 7.36 µM -0.837375865841604 0.171591336182188 no 2783 0.20119066357831 3912 3934738 SGTC_709 3807-1509 243 µM -0.83762894986604 0.171518154958592 no 2784 0.201119564251368 3947 1886677 YPL242C IQG1 SGTC_1737 st035557 69.7 µM -0.837741743347009 0.171485546268151 no 2785 0.201087881841243 3784 5716916 SGTC_775 4577-0580 57.3 µM -0.839043393776247 0.171109524737578 no 2786 0.200722479629996 3976 2006902 SGTC_1074 carmofur 3.8 µM -0.842371503325817 0.170150498419339 no 2787 0.199790019361231 3925 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2626 ethyl orsellinate 100 µM -0.843856951863074 0.169723566276263 no 2788 0.19937467303604 3910 75653 A natural product. SGTC_1761 st044296 37 µM -0.844011946082052 0.169679059070407 no 2789 0.199331365069245 3896 1826700 SGTC_3022 9087993 49.47 µM -0.845223724267132 0.16933135024255 no 2790 0.198992969362821 3936 17173644 SGTC_2205 7238770 200 µM -0.847080005054918 0.168799594789997 no 2791 0.198475264599182 3943 279867 SGTC_1366 1683-0113 21.9 µM -0.847400336053992 0.168707940540286 no 2792 0.198386008625932 3901 708623 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.848210233591148 0.168476352452747 no 2793 0.198160449505161 3916 6708784 An antioxidant flavonoid SGTC_260 nsc-65238 3.989 µM -0.848869768838343 0.168287911149182 no 2794 0.197976881204129 3873 3246252 SGTC_3023 9089636 49.47 µM -0.849152165172419 0.168207266811321 no 2795 0.197898313307274 3975 17249241 SGTC_616 4092-0450 108 µM -0.849530512310353 0.168099260635402 no 2796 0.19779307964436 3925 787165 SGTC_781 4335-2806 94.4 µM -0.84985872767227 0.168005601656543 no 2797 0.197701817052488 4013 845254 SGTC_204 PMA1.184 62.41 µM -0.850155295308075 0.167921002508407 no 2798 0.197619376223434 3931 2252213 YGL008C PMA1 SGTC_1504 k297-0033 30 µM -0.851289175858832 0.167597803629862 no 2799 0.197304368097456 3830 4388117 SGTC_2321 7390090 138.78 µM -0.85138324243993 0.16757100910457 no 2800 0.197278248715634 3937 649046 SGTC_795 0685-0265 78 µM -0.853821660542121 0.166877397525361 no 2801 0.196601905462376 3940 302754 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.854101270076359 0.166797980710622 no 2802 0.196524440132243 3907 6857784 SGTC_599 1935-0052 86.5 µM -0.8544542773139 0.166697751755639 no 2803 0.196426666516032 3916 9557311 SGTC_880 0833-0487 87.2 µM -0.855544372125545 0.166388487707314 no 2804 0.196124925379668 3902 76075 SGTC_1108 betulinic acid 729.144 nM -0.855865722743918 0.166297390061969 no 2805 0.196036028352867 3914 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_390 dec-rvkr-cmk 16.7 µM -0.856787438577589 0.166036277422688 no 2806 0.195781184549771 3958 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1519 esterone 74 µM -0.857468411315841 0.165843535086369 no 2807 0.195593032653552 3898 698 A steroid. SGTC_1052 3253-3998 198 µM -0.858397900603221 0.165580686222054 no 2808 0.195336393227265 3861 5450317 SGTC_89 0302-0250 142.109 µM -0.859162356270149 0.165364708995582 no 2809 0.195125474297618 3992 4203518 YLR208W SEC13 SGTC_1204 4049-0315 18.3 µM -0.859738190260858 0.16520214237321 no 2810 0.194966688916574 4033 588402 SGTC_2822 7994718 71.43 µM -0.860114950921101 0.165095833153684 no 2811 0.194862840246478 3896 1018011 SGTC_2323 6148992 148.28 µM -0.861306870142086 0.164759805278166 no 2812 0.194534526434971 3895 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2897 9048598 12.99 µM -0.866963093450177 0.163171238029276 no 2813 0.192981115827956 3902 6467404 SGTC_2170 morpholine 200 µM -0.869321537032383 0.162511812319857 no 2814 0.192335643040984 3962 121171 Reacts with secondary amines. SGTC_767 0929-0023 86 µM -0.87143144492586 0.161923349395643 no 2815 0.191759311332953 3951 1204563 SGTC_2720 fluspirilene 36.88 µM -0.872267701339377 0.161690498289379 no 2816 0.191531176711082 3931 3396 An atypical antipsychotic. SGTC_1355 1499-0035 1.68 µM -0.873206174673541 0.161429445448862 no 2817 0.191275354933953 3915 1548538 SGTC_2883 9059145 45.46 µM -0.873854346725964 0.16124930556555 no 2818 0.191098789757734 3917 16476510 SGTC_3077 9117319 49.47 µM -0.874081031484614 0.161186336331858 no 2819 0.191037063338404 3895 17154678 SGTC_757 1066-0008 322 µM -0.877768540482071 0.160164261513284 no 2820 0.190034670097941 3974 6842497 SGTC_1868 st057644 42.7 µM -0.877810910609258 0.160152542368155 no 2821 0.190023171241022 3947 688665 SGTC_362 0310-0100 9.03 µM -0.878692619411357 0.159908797918753 no 2822 0.189783980760734 4030 790235 SGTC_2227 7312221 64.1025 µM -0.878836158342974 0.159869140201473 no 2823 0.189745058967158 3993 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1534 6-azauridine 81.6 µM -0.87902613963666 0.159816661028881 no 2824 0.189693551484206 3973 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1581 himbacine 57.9 µM -0.879345404640518 0.159728494767158 no 2825 0.189607012140949 3926 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1287 0971-0001 34.6 µM -0.879353571247006 0.159726239944804 no 2826 0.189604798835302 3931 4665869 SGTC_433 pimozide 108 µM -0.881282932782513 0.159194121632886 no 2827 0.18908235068971 3859 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2162 5663267 200 µM -0.881470849528209 0.159142356279039 no 2828 0.18903151249802 3907 6456493 SGTC_2397 5161689 200 µM -0.88236739068928 0.158895538238729 no 2829 0.188789082015997 3973 2259942 SGTC_1965 Pectolinarigenin 58.4 µM -0.882728523119564 0.158796189293556 no 2830 0.188691483650001 3928 5320438 An anti-inflammatory. SGTC_3296 9122258 64.045 µM -0.882976385185492 0.158728025037953 no 2831 0.18862451533186 3962 4730474 SGTC_1905 st060207 84.5 µM -0.88323827252283 0.158656024553277 no 2832 0.188553773534591 3890 1948547 SGTC_1474 0330-0125 5.35 µM -0.88491943935834 0.158194332695122 no 2833 0.188100041357543 3952 X1474 SGTC_1236 0330-0013 258 µM -0.885151964793817 0.158130544681387 no 2834 0.188037337875048 3967 4617066 SGTC_1555 citronellol 128 µM -0.885261838868764 0.158100409126095 no 2835 0.188007713403123 3865 8842 A terpine precursor. SGTC_2394 5221648 200 µM -0.885444214960876 0.158050396505575 no 2836 0.187958547150273 4017 788586 SGTC_2569 tetrandrine 100 µM -0.885974816483646 0.15790494981048 no 2837 0.187815548941696 3975 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3161 9100388 49.47 µM -0.888040973064694 0.157339419688738 no 2838 0.187259355938285 4013 25236368 SGTC_2712 st079126 47.7 µM -0.888365984581873 0.157250581751522 no 2839 0.187171958202572 3943 3152970 SGTC_710 3448-4187 58 µM -0.889302550818133 0.156994767266884 no 2840 0.186920250493866 3932 3946412 SGTC_2723 salbutamol 83.58 µM -0.89033586778807 0.156712844017939 no 2841 0.186642783603785 3970 9884233 β2-adrenoceptor agonist SGTC_1839 st053978 48 µM -0.891585081675448 0.156372462092987 no 2842 0.186307684636815 3961 3788398 SGTC_2945 9067681 61.76 µM -0.892411930329548 0.156147432943412 no 2843 0.186086089398705 4036 16456930 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.893581694599411 0.155829442997219 no 2844 0.185772872057488 3935 6312947 SGTC_999 SEC7.066 22.7 µM -0.894171097273743 0.155669381030527 no 2845 0.185615176934761 3947 740511 YDR170C SEC7 SGTC_1850 st056238 17 µM -0.895501329670557 0.155308533249247 no 2846 0.185259577658623 3969 5393177 SGTC_2940 9060638 45.86 µM -0.895936160410893 0.15519069795663 no 2847 0.185143430002087 3968 4027022 SGTC_313 3474-0040 5.03 µM -0.897689275142713 0.154716218118453 no 2848 0.184675614380198 3963 1043375 YIL048W NEO1 SGTC_2869 9037858 32.47 µM -0.89854423213079 0.154485172405435 no 2849 0.184447737434672 3913 27187042 SGTC_1325 1431-0015 227 µM -0.898910853155452 0.15438616573169 no 2850 0.184350073284687 3949 1103340 SGTC_499 genistein 192 µM -0.899805872616257 0.154144640356856 no 2851 0.184111784292506 4001 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1433 4060-0023 7.6 µM -0.901575318151135 0.153667882711281 no 2852 0.183641253601637 3980 3840627 SGTC_409 arachidonic acid 100 µM -0.904032782429377 0.153007367173724 no 2853 0.182989009318104 3969 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1640 st009078 66.4 µM -0.904334764661491 0.152926330645369 no 2854 0.182908958993095 3946 690618 SGTC_147 4466-0538 29.23 µM -0.905295982602754 0.152668578573463 no 2855 0.182654302080406 4046 6742687 YHR072W ERG7 SGTC_1574 spiramycin 23.7 µM -0.905566429254812 0.152596109865838 no 2856 0.18258269216906 3959 6419898 An antibiotic and protein synthesis inhibitor. SGTC_582 0987-0078 156 µM -0.906559982972619 0.152330073825128 no 2857 0.182319765722423 4004 1625765 SGTC_3175 9106517 49.47 µM -0.909275903937156 0.151604425010037 no 2858 0.181602253268346 4013 41468073 SGTC_697 0508-1955 564 µM -0.912208390253939 0.150823497586963 no 2859 0.180829514001859 3985 6243113 SGTC_1788 fluconazole 20 µM -0.912799115381368 0.150666510851687 no 2860 0.180674101835307 4048 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1696 st025591 34.7925 µM -0.913331310222048 0.150525171899887 no 2861 0.180534159970136 3991 2787147 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.91426248559443 0.150278085231896 no 2862 0.180289468844139 4035 5379071 SGTC_2513 baicalein 25.65 µM -0.914668155698745 0.150170525557497 no 2863 0.180182933336707 3997 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2658 polymyxin b sulfate 77.05 µM -0.915041558191702 0.150071566707139 no 2864 0.180084906756484 4003 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1278 0874-0585 172 µM -0.917347790803915 0.149461334294512 no 2865 0.179480210873582 4042 766306 SGTC_471 1-acyl-paf 4 µM -0.91746293251842 0.14943091110444 no 2866 0.179450054121805 3930 16759367 SGTC_2424 5537928 59.2 µM -0.919229256091207 0.148964724345102 no 2867 0.178987835835859 4032 5382802 SGTC_1171 0368-0077 21.4 µM -0.919830884965631 0.148806158187021 no 2868 0.178830570493625 3943 3239779 SGTC_1659 st012954 42.1 µM -0.920716010232895 0.148573078442346 no 2869 0.178599357570168 3980 24207262 SGTC_120 rhodamine 6G 52.259 µM -0.92110129243035 0.148471698498708 no 2870 0.178498772771457 4026 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2444 5485484 36.41 µM -0.921565637837216 0.148349576010084 no 2871 0.178377594536846 4077 6790631 SGTC_3085 9117376 49.47 µM -0.922285192363021 0.148160466481449 no 2872 0.178189917886995 4091 16480349 SGTC_1662 st014054 52 µM -0.923540145774378 0.147831032386919 no 2873 0.177862894630824 4030 2838777 SGTC_1695 st026914 34.495 µM -0.92373948515861 0.147778749570104 no 2874 0.177810984444838 3963 3289191 SGTC_101 0490-5701 117.494 µM -0.924264155861488 0.147641197907974 no 2875 0.177674400061558 3812 4661669 SGTC_247 mechlorethamine 29.705 µM -0.92507006558306 0.147430081560498 no 2876 0.177464731384121 3893 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1612 st002233 45.4 µM -0.92507902249727 0.147427736341746 no 2877 0.177462401995632 3995 1035021 SGTC_1901 st060216 58.6 µM -0.925873873524991 0.147219717378583 no 2878 0.17725576515784 3985 688792 SGTC_1956 st077085 54 µM -0.925939461228944 0.147202561335896 no 2879 0.177238721159691 4042 24208685 SGTC_7 0192-1582 4.227 µM -0.926289920578007 0.14711091297112 no 2880 0.177147666318484 4037 252616 SGTC_1286 0929-0070 131 µM -0.930186535772956 0.146094489615559 no 2881 0.176137255951083 4100 1420408 SGTC_686 1319-0111 510 µM -0.931893810764871 0.145650640568979 no 2882 0.175695703261585 4032 4562600 SGTC_1209 2323-2347 50.3 µM -0.932385372787797 0.145523014935601 no 2883 0.175568700671716 4016 5412760 SGTC_664 1222-0054 14.9 µM -0.933152856265038 0.14532390145307 no 2884 0.175370525904456 3976 6813991 SGTC_1730 st033808 45.1 µM -0.935206665566475 0.144791969515373 no 2885 0.174840902034534 3968 1045166 SGTC_1707 st032323 6.317 µM -0.935606947633797 0.1446884502395 no 2886 0.174737798055321 3896 3132057 YMR211W DML1 SGTC_1364 1653-0028 37.6 µM -0.936227906629701 0.144527959090867 no 2887 0.174577928884207 4006 5718652 SGTC_3046 9092212 49.47 µM -0.93813863445487 0.144034870853129 no 2888 0.174086584774998 4066 25236637 SGTC_1786 berberine 21.6 µM -0.938331207531199 0.143985237866479 no 2889 0.174037113372163 3932 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1119 parthenolide 318.541 nM -0.93883936645193 0.143854322477488 no 2890 0.173906611897112 4130 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2937 9044753 11.33 µM -0.939905005240387 0.143580046134257 no 2891 0.173633144855349 3975 6465530 YGL099W LSG1 SGTC_3185 9108267 49.47 µM -0.940353306798097 0.143464766887415 no 2892 0.173518182333684 4013 4910486 SGTC_1960 st011366 51.8 µM -0.940833754688617 0.14334129070438 no 2893 0.173395029991328 4037 3972846 SGTC_1394 3474-0001 65.7 µM -0.941093645875139 0.143274528005216 no 2894 0.173328435746896 3999 5017666 YIL048W NEO1 SGTC_3211 9128781 49.47 µM -0.94179451331824 0.143094588878109 no 2895 0.173148927390737 4056 17194361 SGTC_3237 9133362 49.47 µM -0.943415884091787 0.142678907137639 no 2896 0.172734110829574 3976 43845137 SGTC_2028 5153890 36.43 µM -0.94359792698177 0.142632286607122 no 2897 0.172687575995835 3992 2830968 YPR165W RHO1 SGTC_2423 st077119 87.2 µM -0.945839498742095 0.142059072415144 no 2898 0.172115227938267 3953 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1449 4112-4002 201 µM -0.947549927688801 0.141622732212904 no 2899 0.171679313719433 4088 2059539 SGTC_3120 9124077 49.47 µM -0.9477391658632 0.141574512316473 no 2900 0.171631128478145 4120 18774327 YGL155W CDC43 SGTC_1664 st014217 9.02 µM -0.947843304689712 0.141547981383067 no 2901 0.171604615556239 4068 3982782 SGTC_387 norethindrone acetate 66.7 µM -0.948709226413158 0.1413275052557 no 2902 0.171384260080407 4030 541197 SGTC_3088 9117578 49.47 µM -0.949332917790087 0.141168848743748 no 2903 0.171225658285663 4063 678341 SGTC_1469 k284-2957 126 µM -0.949655625649391 0.14108680476182 no 2904 0.171143632042557 4001 23884841 SGTC_1657 st012939 43.4 µM -0.952016692580269 0.140487520159334 no 2905 0.170544258131409 4047 24207257 SGTC_2197 6588183 93.1375 µM -0.954938152556909 0.139748392218663 no 2906 0.169804487190395 3995 884136 SGTC_3304 9125678 46.087 µM -0.954949506281573 0.139745524898516 no 2907 0.169801616224671 3977 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3053 9095903 49.47 µM -0.954982968376616 0.139737074464784 no 2908 0.169793154994981 4129 17174018 SGTC_1349 flufenamic acid 69 µM -0.959675597637109 0.138555449172439 no 2909 0.168609254197075 3958 3371 A non-steroidal anti-inflammatory. SGTC_811 0416-0114 265 µM -0.95993911127387 0.138489297733168 no 2910 0.168542930218023 4117 6612453 SGTC_1831 st055328 12 µM -0.960816587766615 0.138269174615488 no 2911 0.168322198322317 4043 1103068 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.962998928895414 0.137722748809788 no 2912 0.167774030395369 4003 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1873 rapamycin 2 nM -0.964208631562103 0.137420492881896 no 2913 0.167470668878832 4019 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2343 7990716 14.84 µM -0.965118498139557 0.137193452568335 no 2914 0.167242731362937 4049 6456862 SGTC_2761 levamisole 97.89 µM -0.965530613102901 0.137090701287874 no 2915 0.167139555177501 3998 26879 An alkaline phosphatase inhibitor. SGTC_1765 st044815 90.4 µM -0.967463806336798 0.136609406399574 no 2916 0.166656113119831 4089 645695 SGTC_843 0310-0051 143 µM -0.968948855177566 0.136240468812387 no 2917 0.166285353973067 4079 2065037 SGTC_2043 5101342 149 µM -0.969446539652607 0.136116979421348 no 2918 0.166161220712592 4065 678451 SGTC_2477 5967686 25.23 µM -0.96990650759464 0.136002916695527 no 2919 0.166046548012792 4044 776118 SGTC_3350 9150499 3.57 µM -0.971388972349051 0.135635740870743 no 2920 0.165677308950298 4029 4910996 YPR165W RHO1 SGTC_2904 7225135 42.03 µM -0.972457729833356 0.135371453406738 no 2921 0.165411442002592 4156 4446116 SGTC_1635 st007035 42.4 µM -0.976077338692402 0.13447900220332 no 2922 0.164513070148598 4032 3716403 SGTC_901 1112-0062 60.1 µM -0.976611109547224 0.134347738128145 no 2923 0.164380858494273 4058 1908457 SGTC_591 4299-0174 154 µM -0.976724138552836 0.134319953507643 no 2924 0.164352870766635 4064 5509088 SGTC_1336 1486-0901 104 µM -0.977294392868557 0.134179834625149 no 2925 0.164211714105879 4087 5006114 SGTC_2275 7947463 200 µM -0.979565828248295 0.133622710137242 no 2926 0.163650239833592 4059 1225414 SGTC_3072 9116419 49.47 µM -0.982934161432638 0.132799476692239 no 2927 0.162819921659192 4109 17170162 SGTC_787 4152-0075 138 µM -0.983292458835554 0.132712113414786 no 2928 0.16273176028328 4078 9566539 SGTC_3146 9095609 49.47 µM -0.984343083785606 0.132456168893384 no 2929 0.162473426309879 4121 17173999 SGTC_1812 st052057 4.327 µM -0.984927030280555 0.132314059857799 no 2930 0.162329957489932 4094 3645418 SGTC_2091 4-phenylthiadiazole 200 µM -0.988603439380465 0.131421783799723 no 2931 0.161428601392362 4062 270010 SGTC_2558 carylophyllene oxide 100 µM -0.991291328084104 0.130772059388234 no 2932 0.160771673115174 4196 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2189 6047310 154.431 µM -0.991316479042303 0.130765990327604 no 2933 0.160765534398268 4061 711535 SGTC_3258 9138477 49.47 µM -0.992686735400223 0.130435634361776 no 2934 0.16043132056915 4106 4970355 SGTC_3078 9116413 49.47 µM -0.994057894382611 0.13010563903799 no 2935 0.160097341333778 4003 17177322 SGTC_647 0140-0236 81 µM -0.994651654525233 0.129962918863162 no 2936 0.159952857706456 4088 990837 SGTC_301 4119-0100 24.5 µM -0.99490937304267 0.129901005651021 no 2937 0.159890171884115 4098 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2975 9084847 53.72 µM -0.995427344922477 0.129776632036912 no 2938 0.159764232288764 4149 27211724 SGTC_556 4058-0063 51.5 µM -0.995856678234564 0.129673604529538 no 2939 0.159659893464666 4120 6615692 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.00350739873748 0.127847149484535 no 2940 0.157808054458006 4013 5355888 SGTC_2865 9030313 51.95 µM -1.00356677410178 0.127833045078225 no 2941 0.157793738175548 4046 42562754 SGTC_1065 prochlorperazine maleate 2.48 µM -1.0039827632632 0.127734258661724 no 2942 0.157693460932601 4133 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_633 0437-0093 97.7 µM -1.00422689650655 0.127676308191552 no 2943 0.157634630318485 4030 2831118 SGTC_931 2812-0076 566 µM -1.00438485709267 0.127638822462896 no 2944 0.157596573058522 4052 3450959 SGTC_2993 9054257 71.4286 µM -1.00520878316044 0.12744342007395 no 2945 0.157398163386356 4037 6470217 YGL055W OLE1 SGTC_250 brefeldin a 552.239 µM -1.00582966203383 0.127296309893911 no 2946 0.157248758044796 3953 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1460 k062-0059 9.15 µM -1.00881065394613 0.126591643062443 no 2947 0.156532725297413 3983 1373085 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.01413139876678 0.125340652094152 no 2948 0.155260028676616 4106 66535 A nucleotide analog. SGTC_1897 st060201 15 µM -1.01616664620289 0.124864422893973 no 2949 0.154775018252443 4157 611878 SGTC_515 4092-1064 102 µM -1.02025364952638 0.123911923587926 no 2950 0.153804089746264 4149 717353 SGTC_2593 nobiletin 86.24 µM -1.0205463083417 0.123843913435092 no 2951 0.153734719303077 4130 72344 An anti-infammatory. SGTC_2587 piperic acid 92.2 µM -1.02187888528032 0.123534570026761 no 2952 0.153419113561794 4106 5370536 SGTC_2251 lansoprazole 556 µM -1.0222312845972 0.123452854872289 no 2953 0.153335723584627 4039 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1478 0453-0656 35.7 µM -1.02443861224061 0.12294187605198 no 2954 0.152814076059934 4107 5258496 SGTC_2505 galangin 7.89 µM -1.02457812708527 0.122909629371243 no 2955 0.152781144753258 4002 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1461 k072-0203 53.8 µM -1.02490465053278 0.12283418175188 no 2956 0.152704090036948 4023 5418714 SGTC_1121 fusaric acid 630.51 nM -1.0299360927538 0.12167570414172 no 2957 0.151520003192321 4080 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2661 dactinomycin 12.96 µM -1.03026572091072 0.121600076926195 no 2958 0.151442642968074 4079 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_407 eburnamonine 100 µM -1.03069673962583 0.121501237333067 no 2959 0.151341527087054 3958 3195 SGTC_1241 0364-0022 50.8 µM -1.03076489141029 0.121485614194042 no 2960 0.151325542965894 4143 4563895 SGTC_3198 9112019 49.47 µM -1.03100879931596 0.12142971223124 no 2961 0.15126834671564 4165 45595555 SGTC_2139 5578692 56.4705 µM -1.03120190035407 0.121385467670463 no 2962 0.151223074843701 4082 650991 YMR113W FOL3 SGTC_981 1488-1094 54.9 µM -1.03154656375394 0.121306524332788 no 2963 0.151142292101827 4093 3449522 SGTC_453 enantio-paf c16 10 µM -1.03265917782524 0.121051932342035 no 2964 0.150881711859168 3942 13871343 A lipid and platelet activating factor SGTC_1233 0325-0408 14.2 µM -1.03325905941709 0.120914821556537 no 2965 0.150741340498598 4169 12874 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.03379021597102 0.120793510029491 no 2966 0.150617123293716 4135 4620898 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.03464295057091 0.120598932086812 no 2967 0.150417843893712 4100 442882 SGTC_2083 5306046 65.942 µM -1.03469084217529 0.120588010675413 no 2968 0.150406657100681 4133 539837 SGTC_307 1501-1223 22.3 µM -1.03722837534961 0.120010336184079 no 2969 0.149814718432879 4164 2830329 SGTC_2451 5856223 45.7 µM -1.03906678375048 0.119593039131769 no 2970 0.149386838872058 4097 2179896 SGTC_2172 5754775 163.918 µM -1.03932986527407 0.119533406539286 no 2971 0.14932567486797 4098 2263357 SGTC_997 3996-0078 137 µM -1.04200851539396 0.118927431784551 no 2972 0.14870386549605 4174 735687 SGTC_1680 diphenhydramine 100 µM -1.04414372218853 0.118445953238359 no 2973 0.148209449940582 4126 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_557 1315-0110 16.2 µM -1.04431842746974 0.118406619128888 no 2974 0.148169044976733 4135 6833801 SGTC_836 0330-0104 1.35 µM -1.04516724730758 0.118215642565479 no 2975 0.147972839074375 4156 46494820 SGTC_2013 4024628 200 µM -1.04692030636603 0.117821910271705 no 2976 0.147568167722181 4187 5230760 SGTC_748 act1.228 77.9 µM -1.04843650980297 0.117482124204699 no 2977 0.147218769886534 4087 4421505 YNR035C ARC35 SGTC_661 1304-0007 33.6 µM -1.04866521834097 0.117430930168047 no 2978 0.147166113873339 4152 3117130 SGTC_2355 9061122 103.12 µM -1.05618751770039 0.11575593792469 no 2979 0.145441276193284 4165 5302957 SGTC_1621 st003705 32.4 µM -1.05710577302664 0.11555263775899 no 2980 0.145231658389738 4155 24207032 SGTC_1824 st053723 68.6 µM -1.05943306363515 0.115038516163017 no 2981 0.144701299220964 4184 675225 SGTC_3172 9105863 49.47 µM -1.06512736196771 0.11378745387155 no 2982 0.1434091493514 4210 2348785 SGTC_1588 farnesol 29.9 µM -1.065746647168 0.113651981096292 no 2983 0.143269092366643 4161 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_598 3937-0236 20.2 µM -1.06604731206527 0.113586250120593 no 2984 0.143201127586754 4222 1379313 SGTC_1999 st074831 12.5 µM -1.06649771541954 0.113487834234991 no 2985 0.143099355440393 4122 17112523 SGTC_1447 4239-0816 81.9 µM -1.07226950730259 0.112232041962987 no 2986 0.141799499301525 4173 1341554 SGTC_1936 st074407 74.3 µM -1.07420183437684 0.11181384497091 no 2987 0.141366115210365 4203 809813 SGTC_1136 pergolide 1.05886 µM -1.07603112875509 0.111418974517081 no 2988 0.140956667440153 4138 47811 A dopamine receptor agonist. SGTC_1770 st043884 66.3 µM -1.07800666717494 0.110993657935703 no 2989 0.140515390395508 4166 670149 SGTC_2807 7945238 51.95 µM -1.07865807515783 0.110853670616561 no 2990 0.140370090875655 4199 17148797 SGTC_528 3492-0019 172 µM -1.08052623239685 0.110452906027959 no 2991 0.139953955898509 4173 2869262 SGTC_1003 4049-0218 100 µM -1.08079413004627 0.110395520817286 no 2992 0.139894350076378 4208 295161 SGTC_1237 0330-0133 46.1 µM -1.08241090880022 0.110049651325988 no 2993 0.139534991573491 4116 X1237 YHR072W ERG7 SGTC_1826 st055655 41.6 µM -1.0867734523896 0.109120274753656 no 2994 0.138568471501807 4202 676168 SGTC_457 grayanotoxin iii 135 µM -1.08695822470922 0.109081036576969 no 2995 0.138527636191578 4020 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1991 st073000 8.92 µM -1.08934841365981 0.108574370769605 no 2996 0.138000135388269 4248 4301969 YIL048W NEO1 SGTC_1862 st057513 3.81 µM -1.08954747163022 0.108532251486345 no 2997 0.137956266334405 4169 5393163 SGTC_1539 benzyladenosine 56 µM -1.08968174144881 0.108503847564798 no 2998 0.137926680880497 4171 92208 A nucleotide analog. SGTC_555 4296-0685 37 µM -1.09171776652558 0.108073794702522 no 2999 0.137478586797456 4144 2908540 YHR072W ERG7 SGTC_1319 1306-0155 43.7 µM -1.09445244567691 0.107498103874446 no 3000 0.136878296481113 4243 3122360 SGTC_178 4092-0806 87.505 µM -1.09895760156011 0.106554526512836 no 3001 0.135893279918801 4074 2169044 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.09926549989428 0.106490258051359 no 3002 0.135826138037497 4135 97141 SGTC_2655 perillic acid 100 µM -1.09936943385719 0.106468569950219 no 3003 0.135803478796817 4209 5702197 An apoptosis inducer. SGTC_1102 cgs 12066b 26.1 µM -1.10137406682341 0.106050883091031 no 3004 0.135366943702517 4191 6438352 A 5-HT1B full agonist. SGTC_1438 4092-1045 4 µM -1.10660475770955 0.104966590447934 no 3005 0.134232424699782 4218 1351342 SGTC_2713 st079149 53.4 µM -1.10737505618269 0.10480759232157 no 3006 0.134065902902988 4204 3103253 SGTC_3184 9108758 49.47 µM -1.10954298503483 0.104361044081226 no 3007 0.133598005823487 4226 902885 SGTC_1682 st012968 530 nM -1.11225815241591 0.103803722922371 no 3008 0.13301358554271 4227 24207270 SGTC_954 1189-0853 2.85 µM -1.11326356351371 0.103597898763855 no 3009 0.132797625176146 4140 2828194 SGTC_1040 k898-0338 155 µM -1.11448641085056 0.103347961180405 no 3010 0.13253528552585 4210 20969351 SGTC_34 0469-0683 81.75 µM -1.11570786626394 0.103098745386938 no 3011 0.132273601162825 4173 3690923 SGTC_3227 9130768 49.47 µM -1.11675221702428 0.10288601095144 no 3012 0.132050142282965 4263 17720899 SGTC_2106 5357045 167.29 µM -1.11731087878344 0.102772342471627 no 3013 0.131930712818867 4222 668842 SGTC_810 3825-7150 143 µM -1.12022697754162 0.102180497768682 no 3014 0.131308525278653 4293 22330411 YGL099W LSG1 SGTC_2047 4141938 200 µM -1.12023462587009 0.102178948748364 no 3015 0.131306896077075 4212 3807862 SGTC_1218 1348-1416 30.7 µM -1.12030361303332 0.102164977510868 no 3016 0.131292201471422 4164 6787668 SGTC_2465 5809242 33.21 µM -1.12174618341432 0.101873147346119 no 3017 0.130985187005725 4262 2731748 SGTC_2528 xanthyletin 44.79 µM -1.12352753508292 0.101513619952026 no 3018 0.130606756496123 4243 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3351 9150312 21.596 µM -1.12358426994443 0.101502184448557 no 3019 0.130594716171555 4139 4904905 SGTC_1605 st000082 49.1 µM -1.12438677005185 0.10134053265837 no 3020 0.130424491061458 4178 1114022 SGTC_3192 9110362 49.47 µM -1.12971502308828 0.100271989589971 no 3021 0.129298162425362 4249 16649480 SGTC_1915 st067105 30.6 µM -1.1304685981172 0.100121531747797 no 3022 0.12913941152487 4163 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2222 6885208 172.143 µM -1.13112985342624 0.0999896421744996 no 3023 0.129000220392824 4193 609514 SGTC_2979 9012552 45.46 µM -1.13119252259154 0.0999771491856652 no 3024 0.128987034227541 4235 17100905 SGTC_1373 2887-0003 58.5 µM -1.13302763014247 0.0996118289320724 no 3025 0.128601325202737 4183 776948 SGTC_523 1934-0222 13.7 µM -1.13437188009231 0.0993448447836982 no 3026 0.128319294652493 4171 1361595 SGTC_3221 9128209 49.47 µM -1.13543551340705 0.0991339654792992 no 3027 0.128096443457561 4254 16460723 SGTC_2279 7948423 32.93 µM -1.13645685731442 0.098931778892598 no 3028 0.127882705833564 4218 1247112 SGTC_1842 st055362 61.2 µM -1.13653834991678 0.0989156595151118 no 3029 0.127865662479907 4191 676032 SGTC_3006 9075424 71.4286 µM -1.13839778137305 0.0985483827233214 no 3030 0.127477210033107 4185 7465181 SGTC_94 0334-0113 514.748 µM -1.13994827824329 0.0982428911417827 no 3031 0.127153924925271 4248 6795178 SGTC_1124 fisetin 1.16336 µM -1.14107779804235 0.09802078102839 no 3032 0.126918774750295 4252 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2267 7931562 200 µM -1.14180561789497 0.0978778567409956 no 3033 0.126767413335946 4161 934880 SGTC_504 lovastatin 124 µM -1.14276674176748 0.097689351922069 no 3034 0.126567725381478 4250 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1234 0326-0494 15.5 µM -1.14325139438912 0.0975943982227316 no 3035 0.126467114643108 4320 1547813 SGTC_3156 9099931 49.47 µM -1.14648989343125 0.096961644376392 no 3036 0.125796253315879 4271 18111053 SGTC_1857 st056007 79.3 µM -1.14661939178094 0.0969364051227372 no 3037 0.125769479193715 4210 619834 SGTC_596 1155-0152 116 µM -1.14837724020906 0.0965942771031854 no 3038 0.12540643260444 4227 280313 SGTC_1466 k213-0079 57.5 µM -1.148641732047 0.0965428762291093 no 3039 0.125351870758825 4167 3657981 SGTC_78 0336-0123 156.75 µM -1.15074730125451 0.096134400201931 no 3040 0.124918105329586 4076 6765896 SGTC_2223 6903751 107.57 µM -1.1520587400708 0.0958806267793916 no 3041 0.124648468176248 4203 5598863 SGTC_1752 st044819 83.042 µM -1.15427440628651 0.0954529984557775 no 3042 0.124193842962556 4224 441209 YML126C ERG13 SGTC_2486 5283202 22.39 µM -1.15759520581502 0.0948147082821686 no 3043 0.123514633315735 4285 1377751 SGTC_481 bay k-8644 50 µM -1.15828176336134 0.0946831384461839 no 3044 0.123374535515223 4220 2303 A calcium channel antagonist. SGTC_840 0245-0196 390 µM -1.15946441599897 0.0944568140569694 no 3045 0.123133466500588 4332 3827528 SGTC_2534 helenine 20.12 µM -1.16133851154177 0.094098985428435 no 3046 0.122752131908651 4265 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1148 3909-7663 27.7 µM -1.16512288482081 0.0933794703726501 no 3047 0.121984627348589 4306 4084526 SGTC_2754 granisetron 64.02 µM -1.17055379510183 0.0923540156447649 no 3048 0.120889089444867 4260 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1648 st011736 69.8 µM -1.17345904627324 0.0918088844668323 no 3049 0.120305885350946 4258 2855514 SGTC_298 1391-0729 10 µM -1.17420580646256 0.0916691508259705 no 3050 0.120156300425477 4192 3237558 SGTC_99 0109-0120 622.8 µM -1.17451159178749 0.0916119778227525 no 3051 0.120095085833361 4225 759414 SGTC_2826 7992541 19.48 µM -1.17451900356948 0.0916105923621491 no 3052 0.120093602355452 4275 2985066 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.17509131475545 0.0915036589489882 no 3053 0.11997909251457 4393 16725076 SGTC_244 nsc-207895 1.295 µM -1.18013179359404 0.0905658637188617 no 3054 0.118973900607901 4030 42640 SGTC_1867 st057372 64 µM -1.18321009664742 0.0899966568589525 no 3055 0.118362946235505 4226 688837 SGTC_2300 7976697 71.57 µM -1.18424593558498 0.0898057196117177 no 3056 0.118157861667338 4171 2236109 SGTC_21 0849-0113 22.993 µM -1.18596420042904 0.0894896543920866 no 3057 0.117818218773138 4220 1560156 SGTC_1681 tripelennamine 100 µM -1.18679814263907 0.0893365539100752 no 3058 0.117653625825159 4213 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_820 1582-0060 59.9 µM -1.19237682590275 0.0883173916849325 no 3059 0.116556761398598 4292 3848840 SGTC_1883 5-benzylidenerhodanine 20 µM -1.19240018392724 0.0883131427309091 no 3060 0.116552184109698 4255 1273210 SGTC_1706 st031321 9.9705 µM -1.19351570344271 0.0881104008774217 no 3061 0.116333732905123 4298 6103185 SGTC_1109 tnp00067 928.257 nM -1.19512382595637 0.0878187410677535 no 3062 0.11601932717075 4287 676295 SGTC_473 2-arachidonoylglycerol 10 µM -1.19765587309622 0.0873609726175853 no 3063 0.11552550738388 4114 5282280 An endocannabinoid. SGTC_246 cycloheximide 667 µM -1.20575403456901 0.0859088658741307 no 3064 0.113956171792644 4182 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1300 1094-0077 113 µM -1.20582784486776 0.0858957142970863 no 3065 0.113941938356668 4253 5532636 SGTC_2177 5811945 192 µM -1.20711045065292 0.0856674191140128 no 3066 0.113694805356735 4328 5343475 SGTC_2652 actinonin 100 µM -1.20785986085869 0.0855342395750741 no 3067 0.113550585663895 4325 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2483 5729050 27.16 µM -1.21184537161428 0.0848285684662054 no 3068 0.112785788349852 4316 2865180 SGTC_2007 4011539 71.82 µM -1.2121543258437 0.084774048144143 no 3069 0.112726655725413 4238 45595301 SGTC_1371 2421-0008 32.7 µM -1.21223656177357 0.0847595406194114 no 3070 0.112710919823 4276 2827552 SGTC_2165 5727197 32.143 µM -1.2125935975779 0.0846965762855387 no 3071 0.112642618961801 4400 1361712 SGTC_1026 k007-1105 30.6 µM -1.21647299785926 0.0840146921179908 no 3072 0.111902395546582 4279 7066794 SGTC_2389 9091542 195.52 µM -1.21740960295126 0.0838506839686164 no 3073 0.111724205589928 4277 3626624 YOL127W RPL25 SGTC_2552 juarezic acid 87.02 µM -1.21816829338209 0.0837180066871653 no 3074 0.11158001292634 4250 1549512 SGTC_2673 kobusone 100 µM -1.22171905660574 0.0830991565317649 no 3075 0.11090694363035 4396 6710676 An epoxy ketone and protein crosslinker. SGTC_160 3453-0671 289.699 µM -1.22183994802744 0.0830781475086513 no 3076 0.110884079217167 4329 5322268 SGTC_721 1187-1332 279 µM -1.22373685528977 0.0827490178164145 no 3077 0.110525755833255 4258 25730 SGTC_2280 7785178 200 µM -1.22983895814287 0.0816969049588671 no 3078 0.109378708151571 4296 2954328 SGTC_175 3793-3120 23.7 µM -1.23046079310147 0.0815902581423912 no 3079 0.109262300084868 4310 5322297 SGTC_2370 9071495 200 µM -1.23110694359147 0.0814795523717611 no 3080 0.109141434453526 4306 21791103 SGTC_885 0865-0106 16.8 µM -1.23630152070328 0.0805936715938972 no 3081 0.108173253035721 4270 2793380 SGTC_1767 st044992 70.3 µM -1.23712958292431 0.0804531290859362 no 3082 0.108019489321392 4363 9600693 SGTC_966 1300-0360 30.2 µM -1.23889233840653 0.0801545629001657 no 3083 0.107692685699758 4314 70588 SGTC_1149 3909-7961 23.3 µM -1.24134294663074 0.0797408843819152 no 3084 0.107239542928008 4377 735261 SGTC_963 1269-2853 151 µM -1.24390314187785 0.0793104339202353 no 3085 0.106767606446568 4302 3668223 SGTC_2354 9060492 162 µM -1.24427535677136 0.0792479994599262 no 3086 0.106699118771845 4347 6471895 SGTC_2436 5633522 8.09 µM -1.24537789014946 0.079063281426113 no 3087 0.106496438298675 4304 5724242 SGTC_2833 9001315 45.46 µM -1.24590286226874 0.0789754424674189 no 3088 0.106400029578596 4274 2989378 SGTC_88 0180-0332 8.668 µM -1.24758109476665 0.0786951344471725 no 3089 0.106092252673829 4402 3101745 SGTC_454 lyso-paf C-16 6.67 µM -1.24982202184133 0.0783220182964819 no 3090 0.105682284830874 4346 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_145 3737-0113 38.366 µM -1.25008661326655 0.0782780523078209 no 3091 0.105633954689307 4292 6849351 SGTC_3309 9129340 25.759 µM -1.25296386915561 0.0778011591098592 no 3092 0.105109428032372 4343 17158987 SGTC_1896 st058441 89 µM -1.25363461916918 0.0776903026956063 no 3093 0.104987421023932 4341 688759 SGTC_1199 1638-0010 4.46 µM -1.26216653476666 0.0762906575651847 no 3094 0.103444433928104 4303 3111136 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.26794808083661 0.0753531683474023 no 3095 0.10240824608823 4327 688667 SGTC_1931 st074438 57.1 µM -1.2704411914625 0.0749516256642195 no 3096 0.101963759194133 4351 2787313 SGTC_1926 methyl fluorone black 53.6 µM -1.27329039330328 0.0744947313857467 no 3097 0.101457507200239 3991 72721 Reacts with homocysteine. SGTC_3241 9133421 49.47 µM -1.2752937644136 0.0741747486144572 no 3098 0.101102641994316 4428 17018221 SGTC_2775 cyproheptadine 69.59 µM -1.27965894158519 0.0734811700875323 no 3099 0.100332555292032 4361 2913 A selective serotonin reuptake inhibitor. SGTC_2467 5474540 200 µM -1.28067686383631 0.0733201488351922 no 3100 0.100153594743039 4329 5413519 SGTC_2233 sulbentine 40.3845 µM -1.28474031002536 0.0726800560163759 no 3101 0.0994415235056787 4356 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3339 9145883 14.936 µM -1.28586180255827 0.0725041490485879 no 3102 0.0992456482915016 4261 2030670 SGTC_2127 5253358 187.912 µM -1.28710157938934 0.0723100688458561 no 3103 0.0990294425187983 4259 20612 SGTC_285 1486-1325 46 µM -1.28926019646667 0.0719730996330807 no 3104 0.098653821897367 4404 22310230 SGTC_2102 5377816 72.7585 µM -1.29012217091542 0.0718388786735678 no 3105 0.0985041215755616 4413 1379702 SGTC_2796 7949634 45.45 µM -1.29147204693326 0.0716290707252109 no 3106 0.0982700209708222 4329 2971588 SGTC_405 ebelactone b 50 µM -1.29381806394645 0.0712655539172 no 3107 0.0978641358028193 4292 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2306 7482397 179.52 µM -1.29622576327072 0.0708939537300081 no 3108 0.0974488580063917 4384 891448 SGTC_497 capsazepine 133 µM -1.29678877488804 0.0708072745871029 no 3109 0.0973519370087831 4310 2733484 A calcium channel blocker. SGTC_2675 theaflavin digallate 100 µM -1.29775099063056 0.0706593240098457 no 3110 0.0971864577919511 4296 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1377 2944-0135 198 µM -1.29876455927449 0.0705037344501445 no 3111 0.0970123703758925 4365 1894137 SGTC_2203 7227154 166.4 µM -1.30042425165169 0.0702495294701047 no 3112 0.096727801224833 4388 896304 SGTC_652 0437-0092 114 µM -1.3030598055419 0.069847306912649 no 3113 0.0962771723272872 4308 3091274 SGTC_438 sphingosine 6.67 µM -1.30736355535439 0.0691943075015446 no 3114 0.0955446343281636 4291 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1708 st033234 31.827 µM -1.30834868821077 0.0690454989147207 no 3115 0.0953775340350825 4461 674664 SGTC_755 1995-0008 37.3 µM -1.30969121478964 0.0688431016970613 no 3116 0.0951501583777268 4336 689533 SGTC_3059 1327-0034 3 µM -1.31320941103872 0.0683148738665746 no 3117 0.0945561968290077 4222 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1774 st048371 48.465 µM -1.31586085592764 0.067918852465783 no 3118 0.0941103745553902 4354 4242727 SGTC_1247 0448-0043 5.84 µM -1.31964701022785 0.067356426328989 no 3119 0.0934764497911379 4379 3089013 YGL099W LSG1 SGTC_331 k048-0133 24.5 µM -1.32340949245134 0.0668010897267974 no 3120 0.0928496183742304 4342 6813582 SGTC_349 k015-0014 24 µM -1.32381726579546 0.0667411164086431 no 3121 0.0927818702499001 4392 2196908 SGTC_215 1287-0124 461.5 µM -1.32606252575173 0.0664116405188141 no 3122 0.0924094937836138 4397 5560863 SGTC_521 r062-0005 13.8 µM -1.32766411779873 0.0661773888704829 no 3123 0.0921445462410935 4313 2832033 SGTC_572 0960-0087 17.7 µM -1.33395851359773 0.0652629555456819 no 3124 0.0911087265944201 4354 6796365 SGTC_96 0929-0093 37.281 µM -1.33829722351527 0.0646383679959688 no 3125 0.0903997832806179 4401 6991579 SGTC_300 r073-0011 5.04 µM -1.33848969795911 0.0646107678807195 no 3126 0.0903684281996661 4398 2735780 SGTC_2224 6650123 117.647 µM -1.34086707508293 0.0642706152257376 no 3127 0.0899818068944524 4410 2908370 SGTC_1887 st057648 70.8 µM -1.34359721466254 0.0638817083854055 no 3128 0.0895393353459044 4398 688672 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.34570248755592 0.0635830652161611 no 3129 0.0891992419127493 4293 4330530 SGTC_3294 9122953 26.2835 µM -1.34634379230087 0.0634923092282385 no 3130 0.0890958344535042 4367 16459826 SGTC_3286 9117135 37.221 µM -1.34939105055319 0.0630624451837219 no 3131 0.0886056969252742 4359 3438150 SGTC_962 1254-0300 21.5 µM -1.34971648078187 0.0630166723802579 no 3132 0.0885534718956503 4367 7340576 SGTC_2575 plumbagin 510 nM -1.35119288570143 0.0628093362514092 no 3133 0.0883168264717557 4313 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2168 5727979 200 µM -1.35295548193826 0.062562505924574 no 3134 0.0880349264683029 4315 695210 SGTC_1614 st002383 48.6 µM -1.35383933393966 0.0624390181089453 no 3135 0.0878938208252496 4434 1947235 SGTC_75 0159-0059 199.013 µM -1.35628478200149 0.0620983414106208 no 3136 0.0875042877705434 4470 5377270 SGTC_1459 k035-0031 35.7 µM -1.35630906037473 0.0620949664621841 no 3137 0.0875004269614864 4141 3877128 YMR208W ERG12 SGTC_861 0443-0273 110 µM -1.35861849553706 0.0617745845129418 no 3138 0.0871337556070068 4405 6149169 SGTC_3229 9132204 49.47 µM -1.35995800335162 0.061589350223239 no 3139 0.0869216070477362 4489 17682924 SGTC_2051 5263410 176 µM -1.3616135543316 0.0613610114410939 no 3140 0.0866599376812252 4378 227584 SGTC_2427 5545055 42.75 µM -1.36321395476668 0.061140908376207 no 3141 0.0864075452639517 4326 5372858 SGTC_1458 k015-0034 6.33 µM -1.36398570627236 0.0610349901422186 no 3142 0.0862860321909644 4442 3598957 SGTC_2228 7354201 200 µM -1.36525905187524 0.060860544762172 no 3143 0.0860858220629744 4504 753451 SGTC_17 0960-0276 49.807 µM -1.36817630554631 0.0604623575849907 no 3144 0.0856284482184596 4398 6821114 SGTC_1057 3448-5381 134 µM -1.37451193134239 0.0596046062812957 no 3145 0.0846414043686964 4391 5497911 SGTC_489 paxilline 115 µM -1.3757164993577 0.0594426094754226 no 3146 0.0844547108646939 4376 105008 A toxic potassium channel blocker. SGTC_3163 9099914 49.47 µM -1.37865463667101 0.0590489205049672 no 3147 0.0840006311173402 4496 16268368 SGTC_1308 1187-1617 41.4 µM -1.38024441781523 0.0588367558180575 no 3148 0.0837557010566152 4454 2882570 SGTC_1933 st074711 15.9 µM -1.38441426311216 0.0582831098731102 no 3149 0.0831158220291036 4413 17250958 SGTC_3243 9134147 49.47 µM -1.38601166187149 0.0580721045864912 no 3150 0.0828716712702725 4514 24282180 SGTC_1168 k815-0004 80.5 µM -1.386428165176 0.0580171861746558 no 3151 0.0828081005466025 4415 642433 SGTC_339 3091-4833 71.4 µM -1.38889972469499 0.0576921358010452 no 3152 0.0824316221353597 4259 3240077 SGTC_1425 4048-4433 7.33 µM -1.38912160067256 0.0576630256822762 no 3153 0.0823978881861791 4490 23734946 SGTC_624 k048-0052 28 µM -1.39378214885418 0.0570542275454235 no 3154 0.0816917001728469 4416 6835531 SGTC_1457 k015-0032 57.3 µM -1.39550600501846 0.0568303298665994 no 3155 0.0814316526096915 4411 4302660 SGTC_1380 2291-0730 164 µM -1.39672722056803 0.0566721352729869 no 3156 0.0812478076630022 4425 2999191 SGTC_2783 7738165 71.43 µM -1.39701844640208 0.0566344615521593 no 3157 0.0812040120504674 4413 17201110 SGTC_2404 5161160 200 µM -1.39990182729218 0.0562625239205894 no 3158 0.0807713593946683 4376 2831543 SGTC_2240 6690706 185.951 µM -1.40197604704508 0.0559961558191253 no 3159 0.0804611997878233 4329 805876 SGTC_3099 9120367 49.47 µM -1.40254023322164 0.0559238762401456 no 3160 0.0803769924696929 4474 24824940 SGTC_263 alizarin 107.927 µM -1.4048597134766 0.055627493674826 no 3161 0.0800314991567638 4477 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_682 0kpi-0099 17 µM -1.40503929068792 0.0556045991529258 no 3162 0.0800047975116443 4443 1714895 YML126C ERG13 SGTC_660 4031-1742 102 µM -1.40635405979576 0.0554372040948138 no 3163 0.0798095073791967 4321 6738706 SGTC_2544 sphondin 68.51 µM -1.40805864856703 0.0552207702122828 no 3164 0.0795568521334039 4400 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1777 st045864 34.765 µM -1.40992081186404 0.0549850922853666 no 3165 0.0792815333240302 4438 4691462 SGTC_1864 st057645 30.4 µM -1.41261890968778 0.0546450282839684 no 3166 0.0788839029952072 4479 688666 SGTC_272 doxorubicin 8.13 µM -1.41557767639839 0.0542740239853009 no 3167 0.0784495955645411 4486 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_144 4161-2749 112.381 µM -1.41696738794078 0.0541004551816799 no 3168 0.0782462312372507 4433 797501 YMR168C CEP3 SGTC_1318 1280-3875 124 µM -1.42119365559606 0.0535753115751029 no 3169 0.0776302343014394 4448 373245 SGTC_2105 5350118 200 µM -1.42376413070117 0.0532578921341723 no 3170 0.0772573811394922 4420 2133313 SGTC_3196 9111891 49.47 µM -1.4272253527572 0.0528328345277612 no 3171 0.0767574745031429 4425 18891510 SGTC_643 k048-0106 28.4 µM -1.42903990685585 0.0526110747490118 no 3172 0.0764963818737906 4469 6763920 SGTC_1554 st069299 38.7 µM -1.43214123636314 0.0522337667941714 no 3173 0.0760517025657456 4410 24207999 SGTC_302 1094-0063 18.9 µM -1.43557870499383 0.051818078449409 no 3174 0.0755611289282034 4432 5440289 SGTC_143 4032-1194 15.74 µM -1.43607562931923 0.0517582041894257 no 3175 0.0754904109801754 4484 1806963 SGTC_1623 st003709 20.3 µM -1.43632238893929 0.0517284926383152 no 3176 0.0754553130437586 4425 16192618 SGTC_162 k030-0015 37.8 µM -1.44097805326285 0.0511704556547454 no 3177 0.0747954415597178 4517 1809920 YMR134W ERG29 SGTC_1436 4092-1007 8.32 µM -1.44625968510579 0.0505431999337478 no 3178 0.074052189378061 4457 2881121 SGTC_2112 5488546 200 µM -1.44677460401382 0.0504823763977492 no 3179 0.0739800308857205 4425 600757 SGTC_1604 st002052 72.4 µM -1.44872343748357 0.0502527030630352 no 3180 0.0737074162305305 4508 6254834 YHR062C RPP1 SGTC_701 4424-0219 185 µM -1.4497115444224 0.0501365715864161 no 3181 0.0735694875459634 4479 2911779 SGTC_292 k038-0015 474 µM -1.45475260567295 0.0495474257879861 no 3182 0.0728688816364806 4464 46368540 SGTC_231 b-estradiol 524 µM -1.4555594644155 0.0494536437134046 no 3183 0.0727572202935607 4460 450 A steroid. SGTC_524 r073-0010 27.8 µM -1.45595431348228 0.0494078016381209 no 3184 0.072702624818953 4405 2772106 SGTC_1570 verbenone 133 µM -1.4637430429586 0.0485104436304666 no 3185 0.0716320850329529 4500 29025 A natural terpanoid with antifungal properties. SGTC_2234 tolnaftate 200 µM -1.46729419439808 0.0481056557240704 no 3186 0.0711480211739737 4586 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1321 1326-2144 215 µM -1.47115250864811 0.0476689234531953 no 3187 0.0706249386708399 4448 3513030 SGTC_31 0508-1974 57.237 µM -1.47126028813838 0.0476567693644749 no 3188 0.0706103692522154 4428 6810525 SGTC_592 k241-0073 46.5 µM -1.47643361710582 0.0470762956420575 no 3189 0.0699137618282842 4513 4230158 SGTC_707 0865-0008 204 µM -1.4765312248743 0.0470653982870976 no 3190 0.0699006696053755 4523 723043 SGTC_878 0828-0289 13.7 µM -1.48231009797467 0.0464238162000049 no 3191 0.0691289013239194 4438 745350 YLR208W SEC13 SGTC_2334 9017922 200 µM -1.48493717325427 0.0461344835506287 no 3192 0.0687802338359504 4506 3163164 SGTC_2120 5538279 151.968 µM -1.48506265553818 0.046120699896553 no 3193 0.068763613721441 4460 2058197 SGTC_2128 5255449 168.493 µM -1.48699735338385 0.0459086005589154 no 3194 0.0685077549778549 4414 736008 SGTC_1444 4112-3581 28 µM -1.4873751726638 0.0458672721551279 no 3195 0.0684578751849236 4568 2877249 SGTC_2496 diffractaic acid 79.83 µM -1.48891094155708 0.0456995871285717 no 3196 0.0682554109710682 4475 94870 An apoptosis inducer which activates caspases. SGTC_2961 9083290 32.55 µM -1.49103465033658 0.0454685193279341 no 3197 0.0679761989310502 4452 17741490 SGTC_1304 1165-0502 251 µM -1.49641829527242 0.0448869660244893 no 3198 0.0672723424402933 4488 767425 SGTC_719 2810-4230 27.3 µM -1.50502829882017 0.0439693550931726 no 3199 0.0661584006827431 4509 721079 SGTC_841 0251-0215 91.2 µM -1.50539466519441 0.0439306476709301 no 3200 0.0661113199179731 4540 3888614 SGTC_2012 4023501 200 µM -1.50558889246459 0.0439101382773979 no 3201 0.0660863708194577 4479 3477460 SGTC_1240 0356-0016 42.1 µM -1.51443702391231 0.0429839814932278 no 3202 0.0649575174767179 4465 4305613 SGTC_741 4582-0002 126 µM -1.51644701933182 0.0427758055129961 no 3203 0.0647031786995277 4520 2912688 SGTC_1307 1187-1599 12.2 µM -1.52221802105577 0.0421826264455461 no 3204 0.0639772305576323 4522 1538471 SGTC_36 0335-0881 14.2 µM -1.52387436208461 0.0420136123740236 no 3205 0.0637700495144325 4401 23828853 SGTC_351 caspofungin 25 nM -1.52452860933447 0.041947003783739 no 3206 0.063688357868491 4496 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1441 4106-0040 13 µM -1.53745106000829 0.0406488079543758 no 3207 0.0620914454256961 4552 2904180 SGTC_3256 9138902 49.47 µM -1.5470909750013 0.0397017688315927 no 3208 0.0609206549400822 4629 17228773 SGTC_2903 5923464 63.88 µM -1.55144645935305 0.0392798036541579 no 3209 0.0603973643689826 4540 2876576 SGTC_3245 9134821 49.47 µM -1.55401842663879 0.0390323466773072 no 3210 0.0600900106689375 4524 17014901 SGTC_3154 9100113 49.47 µM -1.55922604094916 0.038535192483642 no 3211 0.0594714447224274 4512 25237525 SGTC_1442 4112-3290 3 µM -1.56611922437208 0.037885071431474 no 3212 0.0586603541435871 4526 704353 SGTC_2964 9083345 53.42 µM -1.56814927435094 0.0376953252337828 no 3213 0.0584231496690594 4497 17741579 SGTC_972 1319-0219 195 µM -1.57180439766882 0.0373556416781834 no 3214 0.0579979606756206 4527 23903702 SGTC_1175 0741-0056 27.6 µM -1.57928919391568 0.0366678546755238 no 3215 0.0571348696605959 4596 765927 SGTC_3210 9128157 49.47 µM -1.5886141839695 0.0358254978519674 no 3216 0.0560737619672806 4484 17590849 SGTC_9 0092-0002 10.449 µM -1.58960612031808 0.0357368335900441 no 3217 0.0559618083188879 4539 759368 SGTC_2388 9080168 200 µM -1.59387482566164 0.035357325033896 no 3218 0.0554820369735425 4554 15943073 SGTC_2656 pseudo-anisatin 100 µM -1.59807908822947 0.034986782845158 no 3219 0.05501268847047 4603 6708809 A neurotoxin. SGTC_3057 9095946 49.47 µM -1.60061616764767 0.03476472373751 no 3220 0.0547309795530206 4589 24540043 SGTC_1197 1601-0112 267 µM -1.6018455157034 0.0346575414224764 no 3221 0.054594887606729 4518 7350313 SGTC_1042 0350-0096 82 µM -1.61809956485855 0.0332657571711072 no 3222 0.05282057114333 4546 3122515 SGTC_1174 0739-0097 51.1 µM -1.61988508099904 0.0331157151206678 no 3223 0.0526284826020859 4571 728447 SGTC_374 0880-0231 82.3 µM -1.6227659279106 0.0328748051046541 no 3224 0.0523197259506817 4418 6833587 SGTC_1632 st005650 90 µM -1.63177954887045 0.0321303583578258 no 3225 0.0513629675398462 4582 2759605 SGTC_1163 k060-0048 49.9 µM -1.63199501154815 0.0321127347506321 no 3226 0.0513402685340144 4569 6809982 SGTC_2332 7982454 138.89 µM -1.6323940037607 0.0320801205561036 no 3227 0.051298255751326 4457 2981748 SGTC_1731 st035964 63 µM -1.63446363378723 0.0319113845973835 no 3228 0.0510807681049497 4477 6739575 SGTC_2108 5365811 200 µM -1.63477092422401 0.0318863939638225 no 3229 0.0510485390621134 4562 780283 SGTC_2495 cafestol 54.53 µM -1.64380855037461 0.0311586005396679 no 3230 0.0501078773162485 4561 16667697 An anti-infammatory. SGTC_2145 5634607 200 µM -1.6477699455502 0.0308439522336546 no 3231 0.0496999442861937 4575 308662 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.65139150282535 0.0305586026020535 no 3232 0.0493293293842444 4604 5106787 A p450 inhibitor. SGTC_2422 chlorphenesin carbamate 384.24 µM -1.65221204395896 0.0304942552916074 no 3233 0.0492456660342951 4516 2724 A muscle relaxant with antifungal properties. SGTC_3344 9148862 3.898 µM -1.65256785564871 0.0304663872426486 no 3234 0.0492094222886547 4597 4905352 SGTC_3009 9080819 71.4286 µM -1.65507881613562 0.0302703218746198 no 3235 0.0489542556714757 4573 17027216 SGTC_1781 st038725 66.3 µM -1.66016642542946 0.0298762672024052 no 3236 0.0484404884493896 4565 4270275 YIL048W NEO1 SGTC_16 erodoxin 22.806 µM -1.6608707711213 0.0298220497649735 no 3237 0.0483697018456066 4624 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2442 5158906 48.48 µM -1.66322334948294 0.029641549900794 no 3238 0.0481338676873532 4569 1893835 SGTC_1072 oxiconazole 14.9 nM -1.66339261506888 0.0296285981595151 no 3239 0.048116935206137 4555 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_348 k064-0012 10.7 µM -1.67160141441707 0.0290060972724981 no 3240 0.0473014728438772 4538 5066323 SGTC_2379 9035213 200 µM -1.68032341268132 0.0283566272585426 no 3241 0.046447204090414 4588 646551 SGTC_1816 st051957 91.6 µM -1.68215722400571 0.0282216264111581 no 3242 0.0462691782003192 4596 674121 SGTC_2452 5863136 48.41 µM -1.68273738260146 0.0281790280750346 no 3243 0.0462129707938811 4544 2184096 SGTC_681 1642-0006 26.6 µM -1.68414714734908 0.0280757386650678 no 3244 0.0460766172891753 4617 4446530 SGTC_2005 4024620 188 µM -1.68793902219309 0.0277994822583088 no 3245 0.0457114674504205 4539 236743 SGTC_733 4069-0007 56.1 µM -1.69381063827778 0.0273761778701692 no 3246 0.0451506359643644 4588 5717425 YNL287W SEC21 SGTC_1990 st072050 59.8 µM -1.70783772482798 0.0263866394533032 no 3247 0.0438332285173564 4590 17233948 SGTC_1879 gemcitabine 100 µM -1.70984840487154 0.026247276627365 no 3248 0.043646954695053 4567 60750 A nucleoside analog which inhibits DNA replication. SGTC_3301 9125354 19.7965 µM -1.71524312380769 0.025876399228017 no 3249 0.0431503307487966 4565 41905162 SGTC_1465 k213-0056 144 µM -1.71596245671701 0.0258272792923941 no 3250 0.0430844570463528 4520 24048857 YMR208W ERG12 SGTC_1957 st077035 62.4 µM -1.71660068395808 0.0257837630391551 no 3251 0.0430260787208305 4619 705593 SGTC_2502 avocadyne acetate 18.59 µM -1.72217555620671 0.0254062541299993 no 3252 0.042518860702593 4558 3952079 SGTC_3325 9138760 55.175 µM -1.72818051035819 0.0250048120615202 no 3253 0.04197793339006 4541 43844959 SGTC_141 0443-0274 32.331 µM -1.73162249470414 0.0247771163780297 no 3254 0.0416703991979336 4530 1627241 SGTC_2855 9016525 58.44 µM -1.7405991993278 0.0241914550939147 no 3255 0.0408769290503202 4552 43811474 SGTC_1575 cyproterone acetate 48 µM -1.74091607849339 0.0241709954573303 no 3256 0.0408491449641556 4589 9880 An androgen receptor antagonist and liver toxin. SGTC_1255 0566-0045 221 µM -1.74130127213561 0.0241461445987743 no 3257 0.0408153916724566 4607 2788469 SGTC_2391 6285546 200 µM -1.74310411099718 0.0240301191434803 no 3258 0.040657715327887 4621 846083 SGTC_269 exalamide 29 µM -1.75338552423672 0.0233773554088689 no 3259 0.0397679270388239 4600 3316 A derivative of salicylamide. SGTC_805 3852-0218 479 µM -1.75778653402667 0.0231025322290288 no 3260 0.039391918713276 4594 6615355 SGTC_854 0422-0053 192 µM -1.76228975541111 0.022824147467402 no 3261 0.0390101769427171 4627 3596728 SGTC_1443 4112-3303 14 µM -1.76553456781394 0.0226253129868822 no 3262 0.0387369829462914 4654 704433 SGTC_2146 5545642 200 µM -1.77339502136252 0.0221496883415136 no 3263 0.0380816367038211 4582 825326 SGTC_1732 st034308 51.822 µM -1.77982818558248 0.0217667316683018 no 3264 0.0375520416901951 4512 830119 SGTC_1259 0671-0132 43 µM -1.78289143685467 0.0215863556350605 no 3265 0.037301988647506 4560 X1259 SGTC_2815 7968870 71.43 µM -1.78475658179294 0.021477148641398 no 3266 0.0371504043667475 4539 2977326 YHR190W ERG9 SGTC_995 3931-2021 34.6 µM -1.79265199828206 0.0210200190841845 no 3267 0.0365142931991522 4616 730143 SGTC_2992 9074591 71.4286 µM -1.79703172655983 0.020770010580623 no 3268 0.0361652915836453 4568 17741321 SGTC_804 1595-0054 20.9 µM -1.79729800396572 0.0207548921754072 no 3269 0.0361441614672201 4622 761523 Stimulates phospholipase C. SGTC_3307 9126885 69.2785 µM -1.79778948604817 0.0207270118192637 no 3270 0.0361051870596045 4603 24824909 SGTC_430 0958-0115 16.4 µM -1.80515468182627 0.0203129898840011 no 3271 0.0355252401188523 4557 6833180 SGTC_550 4123-0385 25.7 µM -1.83696520401769 0.0186044298496457 no 3272 0.0331075161647236 4659 5731123 SGTC_1743 st037606 46.3785 µM -1.84109226037465 0.0183919963074498 no 3273 0.0328040198391132 4598 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3005 9076496 71.4286 µM -1.84137749626989 0.0183773908935684 no 3274 0.0327831291183693 4616 21368410 SGTC_2762 leflunomide 42.06 µM -1.84307610325525 0.0182906187066139 no 3275 0.0326589499116882 4601 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3016 9080866 49.47 µM -1.85717042247715 0.0175839928144281 no 3276 0.0316434558019094 4632 17066299 SGTC_1904 st060225 78 µM -1.85879855083293 0.0175038872948164 no 3277 0.0315278489823329 4630 66595 SGTC_3193 9111931 49.47 µM -1.8588609529528 0.0175008232585425 no 3278 0.031523425015836 4631 17087244 SGTC_1995 st072814 61.1 µM -1.86530584936528 0.0171868255343259 no 3279 0.0310692728616433 4650 5769371 SGTC_870 0573-2213 57.6 µM -1.87775757298232 0.0165937921363397 no 3280 0.0302071683585218 4650 3916321 SGTC_768 0384-0033 77.3 µM -1.88310295429441 0.0163446332499198 no 3281 0.0298432084723615 4621 3965305 YMR134W ERG29 SGTC_2405 ticlatone 3.52 µM -1.88590806389786 0.0162151681174248 no 3282 0.0296536723382104 4469 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1299 1079-1439 3.74 µM -1.888193984776 0.0161103158778634 no 3283 0.0294999565336744 4646 323161 SGTC_3220 9131269 49.47 µM -1.8985074622488 0.0156444439209917 no 3284 0.0288146328533432 4661 17722206 SGTC_1819 st053448 58.6 µM -1.91560167210332 0.0148977298633881 no 3285 0.0277079082877897 4625 2857616 SGTC_1724 st037281 8.293 µM -1.91859589876642 0.014770139445814 no 3286 0.0275177475205979 4624 574124 YDL195W SEC31 SGTC_2694 st077685 81.9 µM -1.9221340794705 0.0146205824960413 no 3287 0.0272944444361677 4595 2838096 SGTC_1440 4100-1550 40 µM -1.93633906583102 0.0140331904470458 no 3288 0.0264130935671248 4694 742806 SGTC_1821 st053465 65.6 µM -1.95348985110613 0.0133511902093905 no 3289 0.0253807893505759 4694 675086 SGTC_2131 toluylene red 5.2905 µM -1.9535798705719 0.0133476874779959 no 3290 0.0253754615517489 4633 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1613 st002381 52.1 µM -1.98770157317738 0.012075864908055 no 3291 0.0234223524209451 4691 551167 SGTC_146 3448-8650 53.125 µM -1.99086146192457 0.0119635843636554 no 3292 0.023248060026197 4648 2891488 YIL048W NEO1 SGTC_166 k072-0058 166.424 µM -1.99137639104979 0.0119453734090214 no 3293 0.0232197613937485 4566 5846229 SGTC_2956 9076196 2.52 µM -2.00191335054037 0.0115779684894029 no 3294 0.0226470257702788 4672 16423868 SGTC_2132 5317594 122.667 µM -2.00192599737517 0.0115775334798534 no 3295 0.0226463455732355 4631 794577 SGTC_2416 tofa 880 nM -2.01915617401181 0.0109978970312214 no 3296 0.021735494915844 4653 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_614 0462-0418 107 µM -2.0362825849858 0.0104469363596963 no 3297 0.0208609937689406 4505 5188303 SGTC_2706 st078239 82.5 µM -2.05358337860657 0.00991494606747896 no 3298 0.0200080161145617 4679 15434492 SGTC_131 0141-0277 33.849 µM -2.06876708161082 0.0094677007980592 no 3299 0.0192839744292584 4650 1547771 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -2.07852051538568 0.00918980347514239 no 3300 0.0188307216735564 4666 364106 SGTC_909 3448-9333 149 µM -2.10840530602834 0.00838228603464585 no 3301 0.0174979729361518 4650 3344074 SGTC_2464 5717415 7.67 µM -2.13379481153988 0.00774587898369607 no 3302 0.0164297904055995 4680 5285744 SGTC_2990 9074105 71.4286 µM -2.13595894894968 0.00769365317159534 no 3303 0.0163413800020287 4658 6502001 SGTC_2117 5521686 200 µM -2.14354036091972 0.00751313233146522 no 3304 0.016034866906307 4712 803312 SGTC_2795 7780010 54.55 µM -2.15863447616282 0.00716480289852304 no 3305 0.015439267927831 4683 953673 SGTC_678 1218-2179 85.9 µM -2.16170801825186 0.00709564585035339 no 3306 0.0153203446035459 4738 6820081 YOR116C RPO31 SGTC_2283 7944793 200 µM -2.17075091873029 0.00689557750383681 no 3307 0.0149750029440452 4689 2970533 SGTC_3290 9121031 71.43 µM -2.17200523963863 0.00686822356620124 no 3308 0.0149276338531508 4713 17014854 SGTC_1389 3405-0187 19 µM -2.17349257260603 0.00683591238074909 no 3309 0.0148716321140558 4708 799890 SGTC_3191 9110352 49.47 µM -2.1936838033854 0.00641037158274709 no 3310 0.0141290745061552 4703 17122424 SGTC_308 4092-1169 104 µM -2.1965433297146 0.0063520403738989 no 3311 0.0140265386807469 4695 2268590 YDL196W YDL196W SGTC_771 0250-0039 27.3 µM -2.20447948218035 0.00619260551878358 no 3312 0.0137453206758477 4687 3005115 SGTC_1715 st032160 10.2275 µM -2.21279710808288 0.00602932094780537 no 3313 0.0134558183788767 4652 5289825 SGTC_203 k066-0004 30.888 µM -2.21692245275898 0.00594976045793422 no 3314 0.0133141955816132 4754 6795412 SGTC_3206 9114350 49.47 µM -2.21755703919806 0.00593760493012285 no 3315 0.0132925249275798 4625 17087243 SGTC_3355 9151058 44.0485 µM -2.23558604807292 0.00560133357015315 no 3316 0.0126894496726601 4729 17015728 SGTC_1193 1488-0126 41.5 µM -2.2440761369069 0.00544891988153047 no 3317 0.0124137515214841 4717 1384710 SGTC_412 gemfibrozil 100 µM -2.26319003219804 0.00511920265806993 no 3318 0.011811988709773 4713 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1046 2001-0062 216 µM -2.26458385439769 0.00509586869766466 no 3319 0.011769114314927 4711 739778 SGTC_905 2-aminofluorene 215 µM -2.28572501639365 0.0047533731838508 no 3320 0.0111351753937359 4744 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3320 9137005 35.139 µM -2.29778619329347 0.00456731152846626 no 3321 0.0107869804811859 4743 4908713 SGTC_55 0767-0285 6.563 µM -2.32601171392593 0.00415706520429791 no 3322 0.0100089628911644 4710 3116166 SGTC_677 0929-0063 136 µM -2.3351657621562 0.00403127886467463 no 3323 0.00976738148619958 4769 1539583 SGTC_1993 st073995 70.8 µM -2.33784325246271 0.00399513704978192 no 3324 0.00969769047645562 4739 3098394 SGTC_3239 9133757 49.47 µM -2.34733023764849 0.00386940193226027 no 3325 0.00945424375271152 4790 17036923 SGTC_2314 7727897 200 µM -2.35371606219148 0.00378677653221376 no 3326 0.00929340127066651 4714 900724 SGTC_1943 st076331 65.2 µM -2.39396824749318 0.00330139645797007 no 3327 0.00833359580619075 4735 24208415 SGTC_2813 7971799 71.43 µM -2.39933219157696 0.00324112796847531 no 3328 0.00821250317054448 4721 2234054 SGTC_2293 7624732 200 µM -2.44262954752131 0.00278974922632557 no 3329 0.00729034775725262 4683 894453 SGTC_750 4073-0104 132 µM -2.46453978854877 0.0025836713226203 no 3330 0.00685946654276915 4533 22330957 SGTC_2291 7917025 104.35 µM -2.48042236735167 0.00244299691508857 no 3331 0.00656134180482654 4709 2964612 SGTC_772 k072-0172 35.3 µM -2.48409272585441 0.00241149002097278 no 3332 0.00649409915466815 4770 5861980 SGTC_1985 st071382 65.5 µM -2.48899314890283 0.0023699972687809 no 3333 0.00640527171746349 4760 6123237 SGTC_2376 9072922 81.32 µM -2.49516532604342 0.00231865628399661 no 3334 0.00629492281482534 4749 17087968 SGTC_765 1319-0117 244 µM -2.51555042029472 0.00215616636685079 no 3335 0.00594233382919908 4756 3487746 YGL099W LSG1 SGTC_1747 st037496 66.6 µM -2.527570666431 0.00206526218500742 no 3336 0.00574273537433231 4731 723305 SGTC_2449 5812982 45.77 µM -2.53687409867181 0.00199730715445908 no 3337 0.00559235851228316 4722 776185 SGTC_1947 st076332 61.6 µM -2.57320501250575 0.0017509435922191 no 3338 0.00503807507402897 4705 24208416 SGTC_1608 st001473 40.5 µM -2.67395715027432 0.00120540078097647 no 3339 0.00374810144831682 4766 7292267 SGTC_2352 9027995 87.8 µM -2.70629509674837 0.00106651896962183 no 3340 0.00340192779327543 4749 2997347 SGTC_2714 st079313 56.9 µM -2.70778454644015 0.00106049057179384 no 3341 0.00338669894182805 4775 2939799 SGTC_1393 3470-5649 58.2 µM -2.7173189195116 0.00102263555761553 no 3342 0.00329065787667886 4777 4108395 SGTC_171 k064-0041 9.68 µM -2.76995381367893 0.000835062404977867 yes 3343 0.00280321210074915 4753 53325 SGTC_1107 amlodipine 47 µM -2.86599443063936 0.000572014669251641 yes 3344 0.00207850779481179 4458 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2312 7706453 155.7 µM -2.88431016741069 0.000531523097902125 yes 3345 0.00196136091116918 4774 976098 SGTC_613 3914-0030 117 µM -2.99612165899603 0.000336549314550839 yes 3346 0.00136718658918285 4702 1145395 SGTC_1986 st071812 45 µM -2.9987074391799 0.000332951421006434 yes 3347 0.00135563758454132 4776 11838594 SGTC_170 4197-0004 226 µM -3.01562904613902 0.000310275178476605 yes 3348 0.00128223393857599 4774 218692 SGTC_2484 5809818 12.04 µM -3.14595022896385 0.00017813719197278 yes 3349 0.000827740874834008 4776 2870548 SGTC_2100 5377183 190 µM -3.44746160895746 4.55694008064803e-05 yes 3350 0.000282940412078319 4804 2844202 SGTC_688 0527-0193 473 µM -3.52811884535145 3.10512056246134e-05 yes 3351 0.000209262102438365 4802 4007154 SGTC_2635 hydroquinidine 100 µM -4.02015770776327 2.51358859337006e-06 yes 3352 2.90795974277027e-05 4798 442912 An experimental heart treatment. SGTC_906 1165-0455 526 µM -4.07769026734573 1.83709513303867e-06 yes 3353 2.27426520417395e-05 4805 3252859 SGTC_355 1311-2252 105 µM -4.42607834484848 2.51990734302806e-07 yes 3354 4.79808419165298e-06 4804 5338538 SGTC_1723 st034307 2.5525 µM -4.74578662170811 3.56248137219637e-08 yes 3355 1.03848787322368e-06 4805 867466 SGTC_1387 3342-1166 1.8 µM -5.03783989763613 5.33329081433378e-09 yes 3356 2.35407497843969e-07 4809 3418228