SGTCid condition conc unit RLP24|YLR009W.score RLP24|YLR009W.strain.pval RLP24|YLR009W.strain.significant RLP24|YLR009W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2887 9044784 58.44 µM 8.86837026563932 2.68158147656622e-12 yes 1 3.71120866628149e-19 2 6465546
SGTC_2838 9002687 71.43 µM 7.29964633375127 6.91714244102477e-09 yes 2 1.44262557398633e-13 3 6457060
SGTC_309 k408-0051 1.48 µM 7.07616401966509 1.88182483203827e-08 yes 3 7.40997223390908e-13 5 3640463
SGTC_832 4083-0019 164 µM 6.96777721988813 3.02542446260738e-08 yes 4 1.60993778136579e-12 6 1990758
SGTC_2993 9054257 71.4286 µM 6.9201478357703 3.71923211885154e-08 yes 5 2.25586281029962e-12 6 6470217 YGL055W OLE1
SGTC_2841 9004761 38.96 µM 6.51184040501113 2.06730040347975e-07 yes 6 3.71177852794869e-11 1 2991039
SGTC_2792 7535235 81.82 µM 6.12842004825118 9.46984594471768e-07 yes 7 4.4378004913413e-10 2 1281891
SGTC_2920 7982904 15.77 µM 5.98285584838578 1.65006458278887e-06 yes 8 1.09629401738505e-09 2 6456808
SGTC_2880 9042983 58.44 µM 5.96965479418654 1.73422707492763e-06 yes 9 1.18878047428474e-09 4 6464714
SGTC_1074 carmofur 3.8 µM 5.89810475048751 2.26693273449718e-06 yes 10 1.83850263391732e-09 16 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_675 1309-0189 238 µM 5.84125395622089 2.79865249124149e-06 yes 11 2.59046771684979e-09 1 4246530
SGTC_2823 7987624 58.44 µM 5.77830749070982 3.52629386777416e-06 yes 12 3.77279066753259e-09 3 2239440
SGTC_1505 k297-0037 20.6 µM 5.48991988354812 9.87136148329645e-06 yes 13 2.01058048792073e-08 1 4089396
SGTC_3027 9089541 49.47 µM 5.15489147487019 3.07229776949469e-05 yes 14 1.26888930478793e-07 8 9943819
SGTC_882 0843-0131 351 µM 4.92904413137992 6.3677330792186e-05 yes 15 4.13164545281429e-07 5 5425421
SGTC_118 0083-0097 135.343 µM 4.77816605174378 0.000101938944849669 yes 16 8.8450632973525e-07 9 5207356
SGTC_1740 st038286 13.222 µM 4.75636411175507 0.000108993456545028 yes 17 9.85554067603214e-07 4 716786
SGTC_2285 7945142 200 µM 4.56692085683233 0.00019272462385433 yes 18 2.47470385935037e-06 7 2970608
SGTC_261 5-fluorouridine 15.376 µM 4.55681565708872 0.000198559554772094 yes 19 2.59674832289761e-06 8 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3033 9090887 49.47 µM 4.52464337388141 0.000218254348112131 yes 20 3.02487150542812e-06 10 19325384
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 4.47927463850887 0.000249141459962721 yes 21 3.74485589880242e-06 3 688667
SGTC_3071 9117417 49.47 µM 4.42512925705523 0.000291327885694534 yes 22 4.81922772797434e-06 9 45595590 YGL055W OLE1
SGTC_517 1365-0151 113 µM 4.42092458147888 0.000294867759929372 yes 23 4.91397369449198e-06 2 768657
SGTC_1131 3454-3128 32.3 µM 4.40569550222042 0.000308026868977616 yes 24 5.27225000971002e-06 10 710982
SGTC_1708 st033234 31.827 µM 4.40069126007093 0.000312468847179783 yes 25 5.39532836878673e-06 3 674664
SGTC_3106 9121286 49.47 µM 4.38070814732168 0.00033080755461045 yes 26 5.9147114544305e-06 1 15943471
SGTC_134 0269-0018 6.916 µM 4.35100730208611 0.000359920587194401 yes 27 6.77567693523369e-06 13 4378915
SGTC_321 4534-3890 65.3 µM 4.29908099778666 0.000416606519332614 yes 28 8.57538946213551e-06 4 699746
SGTC_575 k072-0246 11.9 µM 4.28968321509733 0.0004277114384111 yes 29 8.94640767297258e-06 4 6796779
SGTC_670 4204-0025 119 µM 4.24727524685542 0.00048132111184253 yes 30 1.08193028696235e-05 3 719039
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 4.24335759933609 0.000486575409515659 yes 31 1.10100061083192e-05 4 75037 A free radical scavenger.
SGTC_1064 honokiol 6.76 µM 4.17146505114021 0.000592936333478819 yes 32 1.51323740178989e-05 9 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2044 5102272 200 µM 4.1482370276388 0.000631649645406435 yes 33 1.67522706978348e-05 8 592666
SGTC_2690 usnic acid 100 µM 4.14041243689234 0.000645207352567511 yes 34 1.7334096433131e-05 4 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_567 1080-0542 68.4 µM 4.11563462005923 0.000689931960150712 yes 35 1.93057778210652e-05 3 5950415
SGTC_258 haloperidol 50.781 µM 4.11036875151811 0.000699798057001531 yes 36 1.97513882435734e-05 19 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1497 4476-2978 41.3 µM 4.07218086840006 0.000775332345871182 yes 37 2.32874948635104e-05 3 1528379
SGTC_1052 3253-3998 198 µM 4.04215257668113 0.000839924135898347 yes 38 2.64813752677275e-05 7 5450317
SGTC_2467 5474540 200 µM 4.03666660480581 0.000852246347309003 yes 39 2.71080142424254e-05 6 5413519
SGTC_3054 9094397 49.47 µM 4.02176405849245 0.000886563553315704 yes 40 2.8881951848597e-05 8 2598354
SGTC_578 3460-0051 92 µM 4.01431866113501 0.000904180370325845 yes 41 2.98088788888701e-05 4 2876744
SGTC_2050 5263056 171 µM 4.00085592161202 0.000936854119417849 yes 42 3.15568895294358e-05 26 763468 YGL055W OLE1
SGTC_2893 9048488 25.97 µM 3.91883699330287 0.00116047837719337 no 43 4.44886309041514e-05 12 6467338
SGTC_115 0527-0192 112.043 µM 3.85095351039085 0.001381451389503 no 44 5.88294172518058e-05 26 4233931
SGTC_1564 D-Arginine 115 µM 3.84642472071495 0.00139748037299005 no 45 5.99269660406953e-05 10 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1178 0988-0033 191 µM 3.8152903205362 0.00151235442707793 no 46 6.80114580139084e-05 8 5392207
SGTC_1233 0325-0408 14.2 µM 3.79879084388583 0.001576663269619 no 47 7.2701865495319e-05 6 12874
SGTC_2757 clomiphene 4.22 µM 3.77910402014991 0.00165665159668442 no 48 7.86968347631963e-05 13 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1461 k072-0203 53.8 µM 3.76829834219532 0.00170211015668631 no 49 8.21820945745314e-05 8 5418714
SGTC_423 5-fluorouracil 457 µM 3.75227315637582 0.00177161990236063 no 50 8.76191872267078e-05 30 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1466 k213-0079 57.5 µM 3.74286184835954 0.00181363573692032 no 51 9.09681334617912e-05 17 3657981
SGTC_3214 9129694 49.47 µM 3.71977360810429 0.00192057637343494 no 52 9.97007161198459e-05 7 17158655
SGTC_285 1486-1325 46 µM 3.70827494064031 0.00197594556296927 no 53 0.000104338006513359 8 22310230
SGTC_2811 7967822 32.47 µM 3.67552984839647 0.00214165486825762 no 54 0.000118678143305277 7 2232244
SGTC_2019 4016004 108 µM 3.65590416921442 0.00224691414309536 no 55 0.00012813854282953 10 45595336
SGTC_1931 st074438 57.1 µM 3.65324703204019 0.00226151996324981 no 56 0.000129472444538369 16 2787313
SGTC_1307 1187-1599 12.2 µM 3.6440603140484 0.00231268289345416 no 57 0.000134185243420784 5 1538471
SGTC_921 1561-0023 372 µM 3.64215349448646 0.00232343286918451 no 58 0.000135183386497381 10 24050882
SGTC_64 000l-0018 272.079 µM 3.64063681253453 0.00233201567071641 no 59 0.000135982273003082 54 6811119
SGTC_36 0335-0881 14.2 µM 3.64003942873279 0.00233540409815905 no 60 0.000136298147793597 37 23828853
SGTC_691 1548-0686 185 µM 3.62374470702341 0.00242956581824484 no 61 0.000145184110839823 15 46495133
SGTC_1698 5-fluorocytosine 1.055 µM 3.61484658207696 0.00248242265774293 no 62 0.000150262767320191 17 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_213 1246-0773 967 nM 3.60956608116177 0.00251427954454066 no 63 0.000153354817674035 3 6251622
SGTC_2687 chenodiol 100 µM 3.60607548643668 0.00253554049854032 no 64 0.000155431371223793 7 5702181 A cholesterol synthesis inhibitor.
SGTC_708 3448-5400 146 µM 3.59767745096167 0.00258735972175886 no 65 0.000160535719040661 25 3462195
SGTC_3228 9131799 49.47 µM 3.59623652834482 0.00259634636179864 no 66 0.000161427131180614 4 17015818
SGTC_232 clozapine 119 µM 3.55957098797468 0.00283471980154985 no 67 0.000185730558353382 5 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_925 2064-1272 59.6 µM 3.53440593573407 0.00300956636733971 no 68 0.00020434643772522 8 6815817
SGTC_1565 sinapyl alcohol 95.1 µM 3.52437296260361 0.00308194281502478 no 69 0.000212243152613357 8 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1436 4092-1007 8.32 µM 3.52173131268597 0.00310125816977593 no 70 0.000214369223394349 4 2881121
SGTC_1999 st074831 12.5 µM 3.51210921937205 0.00317253843947222 no 71 0.000222282630038377 17 17112523
SGTC_2843 9000894 45.46 µM 3.51131896423829 0.0031784576488043 no 72 0.000222944523730295 3 2242070
SGTC_2549 cedrol 20.94 µM 3.46624621881214 0.00353296314451201 no 73 0.00026388985875097 19 6708665 A sedative which affects the nervous system.
SGTC_1275 0867-0008 21.1 µM 3.45322031927824 0.00364182647337773 no 74 0.000276968190532069 7 3422836
SGTC_2911 7942208 15.64 µM 3.42961212189253 0.00384682694552673 no 75 0.000302222321257402 3 1243384
SGTC_473 2-arachidonoylglycerol 10 µM 3.42386208633689 0.00389829768617219 no 76 0.000308689720092173 9 5282280 An endocannabinoid.
SGTC_400 oxethazaine 37.5 µM 3.41263684714074 0.00400056041883879 no 77 0.000321688075922938 6 4621 A local anesthetic.
SGTC_887 0885-0007 9.62 µM 3.38940198873954 0.00421989698107576 no 78 0.000350226219090503 16 5719458
SGTC_562 3772-2733 112 µM 3.38369991971181 0.00427534171715204 no 79 0.00035758060120455 17 2876874 YIL048W NEO1
SGTC_2958 9077254 16.72 µM 3.35190613716134 0.00459659945032193 no 80 0.000401286121333425 12 16457351
SGTC_563 tetrahydrosecaminediol 614 µM 3.33085447298427 0.00482100270039529 no 81 0.000432899261963149 7 334274 A psychoactive constituent of the cannabis plant.
SGTC_1160 4092-0570 10.5 µM 3.32034553854766 0.00493663768261771 no 82 0.000449530473283481 15 4994975
SGTC_1252 0493-0875 34.8 µM 3.30646782482818 0.0050931248266842 no 83 0.000472401001939417 16 3960963
SGTC_3270 9137563 49.47 µM 3.29072493373729 0.00527597759193629 no 84 0.000499647871724772 3 17015724
SGTC_104 0074-0074 590.992 µM 3.27480608203201 0.00546678883866887 no 85 0.000528672633768168 27 3943124
SGTC_2192 5915882 198.485 µM 3.26977894621743 0.00552830789637422 no 86 0.000538157791383458 20 2876149
SGTC_2455 5377712 9.75 µM 3.25375318324961 0.00572854707411837 no 87 0.000569455928324868 11 2243908
SGTC_809 3998-0021 90 µM 3.23719715394902 0.00594214701457551 no 88 0.000603549928722691 17 715485
SGTC_230 MPP+ 141.667 µM 3.21671251964402 0.00621618738996442 no 89 0.000648342290062141 10 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2661 dactinomycin 12.96 µM 3.21573077438556 0.00622959766257262 no 90 0.000650564168240413 4 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2664 lyso-paf C-16 73.48 µM 3.19637649955952 0.00649925225039703 no 91 0.000695826941627275 11 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3029 9088683 49.47 µM 3.1922846850968 0.00655756644886064 no 92 0.000705760688203004 10 25236615
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 3.18913379479694 0.00660278598149534 no 93 0.000713499072079947 5 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 3.1886215948134 0.00661016273677107 no 94 0.000714764368264105 15 23847180
SGTC_3351 9150312 21.596 µM 3.17951936750263 0.00674247468602266 no 95 0.000737597554636751 21 4904905
SGTC_1570 verbenone 133 µM 3.17799527677701 0.00676485647348445 no 96 0.000741485833301932 8 29025 A natural terpanoid with antifungal properties.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 3.17402994609363 0.00682339655651546 no 97 0.000751690895564789 12 688803
SGTC_754 3474-0146 171 µM 3.17299402678628 0.00683876333960291 no 98 0.000754378142537918 10 24762078
SGTC_3162 9099653 49.47 µM 3.16293412974425 0.00698958845535191 no 99 0.00078093833516967 3 25237511
SGTC_1077 5-fluorocytosine 377 nM 3.15713644784071 0.00707783869473911 no 100 0.000796633865562028 24 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1055 3448-0672 86 µM 3.14050629933935 0.00733645519175377 no 101 0.000843280401855932 29 748378
SGTC_274 sirtinol 40.1 µM 3.13730219104994 0.00738722865470847 no 102 0.000852551431343249 20 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1945 st075991 56.6 µM 3.13163479717334 0.00747779490446913 no 103 0.000869179822817175 20 1084980
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 3.12087810727655 0.00765238271323321 no 104 0.000901563263996114 34 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1702 st027038 51 µM 3.11271190292333 0.00778731171876966 no 105 0.000926884404128308 11 5521182
SGTC_2357 9067248 200 µM 3.10150045509482 0.00797596495887748 no 106 0.000962712882045474 10 9150235
SGTC_188 3229-0966 278.469 µM 3.10137306145281 0.00797813148211789 no 107 0.000963127204109953 35 5722370
SGTC_3178 9107506 49.47 µM 3.09234533013505 0.00813298544336707 no 108 0.000992908441448993 18 8897194
SGTC_1685 st024049 53.0905 µM 3.08119995286643 0.00832780232254715 no 109 0.00103084074298205 8 1941139
SGTC_1916 st067606 49.2 µM 3.06745476266686 0.00857369703359473 no 110 0.0010794506755102 16 19590279
SGTC_1452 4194-0072 190 µM 3.04139105989478 0.00905750115791409 no 111 0.00117743881826155 11 1343545
SGTC_788 1182-0090 188 µM 3.03009183436397 0.00927456422513841 no 112 0.0012223969463447 24 5715185
SGTC_1261 0712-0010 12.7 µM 3.02882059300504 0.00929926792901702 no 113 0.00122755216066671 20 2840123
SGTC_3104 9120930 49.47 µM 3.01265828291752 0.00961840096054228 no 114 0.00129485172703 15 17014836
SGTC_830 4076-0286 57.8 µM 3.01092602177609 0.00965316679486633 no 115 0.00130226149661503 18 6866659
SGTC_2282 7944268 200 µM 3.00457591445648 0.00978155193503024 no 116 0.0013297569053495 16 2970414
SGTC_1681 tripelennamine 100 µM 2.99334151298521 0.0100123429711382 no 117 0.00137970391968358 24 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2218 6965428 192.983 µM 2.98611370687237 0.0101633256524624 no 118 0.00141273780897018 6 675684
SGTC_3007 9078383 71.4286 µM 2.98143847210221 0.0102620418375332 no 119 0.00143448845472308 16 6496995
SGTC_263 alizarin 107.927 µM 2.97021486689752 0.0105024447893345 no 120 0.0014879576105606 32 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2859 9028643 45.46 µM 2.96446682894761 0.0106274538096173 no 121 0.00151603965003444 8 17151580
SGTC_827 3253-0474 693 µM 2.93768819740732 0.0112270710533639 no 122 0.00165334702884448 16 5402065
SGTC_1456 k015-0012 13 µM 2.93514644078293 0.0112854846510122 no 123 0.00166695153248742 28 2989616
SGTC_3056 9094900 49.47 µM 2.92413535587567 0.0115415979670431 no 124 0.00172707255904641 17 25236784
SGTC_2374 9071832 200 µM 2.91508271626634 0.0117559246731872 no 125 0.00177797141059043 13 17381698
SGTC_2654 protoveratrine a 100 µM 2.90973761338124 0.0118840882235088 no 126 0.00180866150551681 12 5702278 A heart drug and vasodilator.
SGTC_2734 clemastine 41.6 µM 2.90794709143592 0.0119272910966806 no 127 0.00181904941929689 7 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_571 k831-0106 44.2 µM 2.89672879911802 0.0122010862269725 no 128 0.00188537784752042 18 4783639
SGTC_316 k060-0003 58.6 µM 2.88992162027386 0.0123698649228042 no 129 0.00192668944870842 18 6152314
SGTC_1343 1487-0095 224 µM 2.88879632932992 0.0123979595476667 no 130 0.00193359731710967 13 4560101 YGL055W OLE1
SGTC_1296 1068-0102 11.9 µM 2.87545107031166 0.0127353815094856 no 131 0.00201725335843546 6 767053
SGTC_3275 9138069 49.47 µM 2.87355134878305 0.0127840544038073 no 132 0.00202942545965289 9 17617007
SGTC_610 4215-0184 155 µM 2.85460395048415 0.0132783789291704 no 133 0.00215452637372168 36 5605015
SGTC_26 0302-0163 425.158 µM 2.84655282698476 0.0134933748155613 no 134 0.00220976978404266 25 3100915
SGTC_380 3970-0968 6 µM 2.84048967435888 0.0136572617896472 no 135 0.00225221655944661 15 2891601
SGTC_881 0833-0569 170 µM 2.82354292086068 0.0141244716996138 no 136 0.00237480330141954 20 5418700
SGTC_1175 0741-0056 27.6 µM 2.82163076436107 0.0141780432632408 no 137 0.00238900769363434 24 765927
SGTC_2290 7904846 200 µM 2.81193444826258 0.0144524008121359 no 138 0.00246222690333579 32 2962154
SGTC_630 4356-0227 183 µM 2.81034679773298 0.0144977561300509 no 139 0.00247440716735713 26 779312
SGTC_2871 9038510 12.99 µM 2.80296134338407 0.0147103546727491 no 140 0.0025317869072332 22 4945164
SGTC_385 1494-0393 12.4 µM 2.79194490740819 0.015032456774825 no 141 0.00261961378724039 19 3090647
SGTC_549 1661-1316 519 µM 2.78809774777188 0.0151463604267884 no 142 0.00265092720050544 23 2857282
SGTC_3126 9127922 49.47 µM 2.77346458911141 0.0155864069608951 no 143 0.00277314380969698 56 45595682
SGTC_1062 mesoridazine 14.2 µM 2.77121177735025 0.0156551185069729 no 144 0.00279240452925994 16 4078 A neuroleptic.
SGTC_2463 5473429 200 µM 2.75225565046611 0.0162436499881294 no 145 0.00295931484058541 14 5399405
SGTC_3233 9132340 49.47 µM 2.75050800547066 0.0162988512003697 no 146 0.00297514688106339 26 17682950
SGTC_3346 9158254 43.5805 µM 2.7478272912469 0.0163838366022845 no 147 0.0029995800255325 40 17639500
SGTC_3177 9107506 49.47 µM 2.74657061539178 0.0164238068502308 no 148 0.00301109601152688 8 8897194
SGTC_1073 triclabendazole 3.09 µM 2.73651075476644 0.0167467937492206 no 149 0.00310472826082706 13 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2533 agelasine 13.65 µM 2.73028842705465 0.016949278567855 no 150 0.00316394679622407 35 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2453 5731132 22.18 µM 2.72403608908374 0.0171548446927426 no 151 0.00322447295871091 22 1362040
SGTC_2970 9090938 41.86 µM 2.7223219787751 0.0172115724240069 no 152 0.00324124745544296 30 17217104
SGTC_2047 4141938 200 µM 2.71649833950589 0.0174055020086231 no 153 0.00329882630737813 16 3807862
SGTC_1737 st035557 69.7 µM 2.71528628769105 0.0174460975819966 no 154 0.00331092498603568 24 5716916
SGTC_2481 5478948 45.16 µM 2.71230829461019 0.0175461837815162 no 155 0.00334082087086383 25 77792
SGTC_1429 4049-0205 9.46 µM 2.67002234097085 0.0190210902407826 no 156 0.00379231001228143 13 22774478
SGTC_1943 st076331 65.2 µM 2.66260784409628 0.0192902787466554 no 157 0.00387688594764432 11 24208415
SGTC_3245 9134821 49.47 µM 2.64437320818727 0.0199661039297775 no 158 0.0040921181180491 24 17014901
SGTC_39 0986-0283 58.349 µM 2.6387957527119 0.020176789777521 no 159 0.00416005457929496 29 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1622 st003707 19.4 µM 2.63367824885401 0.0203717566105929 no 160 0.00422327436192042 24 10140899
SGTC_3047 9092122 49.47 µM 2.63177825432933 0.0204445480113903 no 161 0.00424696404449602 28 17173831
SGTC_2000 st075254 36.4 µM 2.62252675582251 0.0208021427200226 no 162 0.00436402071608494 16 17234175
SGTC_1215 3852-0577 11.2 µM 2.6157211595459 0.0210685651825879 no 163 0.00445196189388888 22 2884876
SGTC_1832 st054113 55 µM 2.60249214556175 0.0215947143417004 no 164 0.0046274467548623 20 1251267
SGTC_2708 st078559 56 µM 2.58265463885399 0.0224044825083973 no 165 0.00490217065205118 11 17250902
SGTC_2916 7875993 68.79 µM 2.57345211578191 0.0227887394678002 no 166 0.00503447894533906 26 1299250
SGTC_1093 fluphenazine 7.97 µM 2.57049778708662 0.0229132708465619 no 167 0.00507762377817879 25 6602611 An atypical antipsychotic.
SGTC_831 k061-1017 217 µM 2.56860707918458 0.0229932687548229 no 168 0.00510540802050669 40 1240153
SGTC_12 0849-0099 9.267 µM 2.56845974842588 0.0229995123470719 no 169 0.00510757874209465 22 6071388
SGTC_1223 0764-0573 147 µM 2.56828880360792 0.0230067584469382 no 170 0.00511009841492833 13 1609797
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 2.56435851923739 0.0231738884728819 no 171 0.00516833557007887 29 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2288 7946289 167.31 µM 2.56005294055636 0.0233581494240091 no 172 0.00523281095311258 25 1246052
SGTC_1940 st075990 51.1 µM 2.5458820437691 0.023973334301727 no 173 0.00545010070908745 25 1084979
SGTC_1449 4112-4002 201 µM 2.54303332588831 0.0240986321152629 no 174 0.00549473735453803 23 2059539
SGTC_1683 st010134 710 nM 2.5186544820416 0.0251935757900028 no 175 0.0058902096982318 28 3818134
SGTC_1806 st050005 60.3 µM 2.51797851196129 0.0252245205590453 no 176 0.00590152608004787 28 5194765
SGTC_1292 0kpi-0043 232 µM 2.51226713977586 0.0254872510755883 no 177 0.00599791216818684 20 3333905
SGTC_798 1287-0182 476 µM 2.50336602876496 0.0259012803966321 no 178 0.00615091222578336 24 1649755
SGTC_2891 9063876 19.48 µM 2.50316800416466 0.0259105549936808 no 179 0.00615435500777994 16 6472478
SGTC_952 1185-0122 232 µM 2.49438676681763 0.0263246315683521 no 180 0.00630874884282954 24 678600
SGTC_3075 9116269 49.47 µM 2.48857986855502 0.0266014811725046 no 181 0.00641272130399465 29 17015205 YNL244C SUI1
SGTC_2763 lisinopril 49.32 µM 2.47669499934754 0.0271756911149484 no 182 0.0066302582964559 16 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_602 3130-1533 38.1 µM 2.47299754051159 0.0273564267778387 no 183 0.00669925325364932 42 720941
SGTC_2331 7980721 200 µM 2.47105805670405 0.027451630912355 no 184 0.0067356973211261 34 2981221
SGTC_2946 9065502 71.43 µM 2.46764628834891 0.027619776007697 no 185 0.00680023181556256 11 16489101
SGTC_957 1187-1561 14.1 µM 2.45924260706257 0.0280376060506138 no 186 0.00696152476044267 41 1538454
SGTC_76 0433-0009 400.328 µM 2.45658000847099 0.0281710831865135 no 187 0.00701332821288831 24 2841569
SGTC_816 0325-0417 81.3 µM 2.44161965683112 0.0289309237457262 no 188 0.00731077098295199 27 68101
SGTC_974 1326-0144 138 µM 2.43106181187101 0.0294773499028056 no 189 0.00752732299617993 36 5411856
SGTC_1435 4092-0789 56.7 µM 2.42846886444667 0.0296128517411337 no 190 0.00758136348456992 30 2248285
SGTC_1483 3453-0561 55.9 µM 2.42436901689881 0.0298281555439788 no 191 0.00766750707159392 31 4546991
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 2.41871179460825 0.0301273757085535 no 192 0.00778778766284907 25 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2961 9083290 32.55 µM 2.4094821667374 0.0306208856687207 no 193 0.00798758838809163 19 17741490
SGTC_609 0986-0026 86.3 µM 2.40404049025449 0.0309149774914916 no 194 0.00810748859684568 40 2848610
SGTC_2874 9043904 71.43 µM 2.40341816012248 0.0309487593836893 no 195 0.00812130110984365 26 4463428
SGTC_3325 9138760 55.175 µM 2.40128545856814 0.0310647604523538 no 196 0.00816879305179518 27 43844959
SGTC_1557 sumaresinolic acid 42.3 µM 2.40071082976861 0.0310960768862627 no 197 0.00818163079801106 18 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1591 genipin 88.4 µM 2.40054050407798 0.0311053644055047 no 198 0.00818543943777328 34 442424 A DNA cross-linking agent.
SGTC_1780 st038448 24.544 µM 2.39727413108353 0.0312839176432495 no 199 0.00825878051815244 36 728868 YDL195W SEC31
SGTC_737 1950-0117 57.9 µM 2.39306713706066 0.0315151371462063 no 200 0.00835409172885392 33 5393513
SGTC_2972 9093619 59.92 µM 2.39289159132506 0.0315248158903422 no 201 0.00835808969578566 27 25236256
SGTC_654 1124-0271 80.9 µM 2.39012267705529 0.0316778057470524 no 202 0.00842137292482274 41 5403748
SGTC_163 TUB2.036 7.546 µM 2.38583507911536 0.0319159170582809 no 203 0.00852019543770882 85 15992207 YJR013W GPI14
SGTC_245 methotrexate 289.6 µM 2.38345152022033 0.0320489258180374 no 204 0.00857557168356764 39 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1899 st063254 59.6 µM 2.38072565724369 0.0322015966930219 no 205 0.00863928733497071 25 3093813
SGTC_1319 1306-0155 43.7 µM 2.37790974608348 0.0323599408961816 no 206 0.00870554345329228 28 3122360
SGTC_347 4534-1311 26.2 µM 2.37296311825546 0.0326396549017699 no 207 0.00882301292154237 25 2862016
SGTC_3050 9093513 49.47 µM 2.3701236859103 0.0328011133413477 no 208 0.00889106773079573 40 25236664
SGTC_1914 st062367 72.6 µM 2.36982985635803 0.032817858879367 no 209 0.00889813635864642 34 978205
SGTC_1136 pergolide 1.05886 µM 2.36002044971834 0.0333809609654174 no 210 0.00913696384020743 57 47811 A dopamine receptor agonist.
SGTC_2825 7998094 58.44 µM 2.35775835481435 0.0335119375636079 no 211 0.00919282835862468 44 2987815
SGTC_2982 9019404 25.97 µM 2.35688365149421 0.0335626966794063 no 212 0.00921450998567664 28 22333232
SGTC_1645 Cervolide 78 µM 2.3507975664142 0.0339176273482043 no 213 0.00936661116886701 33 23173 A fragrance.
SGTC_2873 9040596 71.43 µM 2.34971520263409 0.0339810712663283 no 214 0.00939389002127233 51 6463863
SGTC_419 nsc-638432 893 µM 2.34868206178065 0.0340417209401783 no 215 0.00941999310282662 28 368090
SGTC_3081 9117243 49.47 µM 2.33856174404206 0.0346405450885823 no 216 0.00967906332844279 77 45595589
SGTC_2080 5212524 12.4 µM 2.33670717352255 0.0347512134403159 no 217 0.00972720764511776 34 260183
SGTC_529 4076-0302 30.3 µM 2.33486061817534 0.0348616917736153 no 218 0.00977535162508424 26 5816522
SGTC_2412 st077135 33.4 µM 2.31894146032315 0.0358261317085742 no 219 0.0101991053354887 35 13258915
SGTC_2214 7179297 48.276 µM 2.30968643963444 0.0363968121245474 no 220 0.0104527600483931 21 769744
SGTC_3335 9143315 29.6265 µM 2.30743402589902 0.0365368196980417 no 221 0.0105153180967451 29 4899691
SGTC_1120 ficusin 1.78878 µM 2.29219970376016 0.037495377562096 no 222 0.0109470610233288 30 6199 A DNA cross-linker.
SGTC_844 0330-0132 15.3 µM 2.29136942146998 0.0375482043482986 no 223 0.0109710282921361 23 2828079
SGTC_3002 9075603 71.4286 µM 2.28734447849218 0.0378051537471157 no 224 0.0110878621292939 37 20105405
SGTC_2327 6189656 200 µM 2.28684145289123 0.0378373671744017 no 225 0.0111025394788638 32 5349088
SGTC_516 3992-2719 87.3 µM 2.28538840745048 0.0379305450711219 no 226 0.011145031573006 28 5350887 YDR037W KRS1
SGTC_2105 5350118 200 µM 2.27340278000392 0.0387062964860688 no 227 0.0115009593874472 47 2133313
SGTC_1893 st059353 36.1 µM 2.2732008715674 0.03871947458411 no 228 0.0115070389040603 45 3112488
SGTC_1256 0570-0116 285 µM 2.27198264051251 0.0387990632930593 no 229 0.0115437794232091 44 410638
SGTC_34 0469-0683 81.75 µM 2.26798746359856 0.0390610092310179 no 230 0.0116649853897682 33 3690923
SGTC_481 bay k-8644 50 µM 2.26505171174699 0.039254409638192 no 231 0.0117547531863899 28 2303 A calcium channel antagonist.
SGTC_1417 3966-0327 90.4 µM 2.25679444092831 0.0398025605852085 no 232 0.0120104611361547 31 651118
SGTC_1273 0849-0096 14.1 µM 2.25000246983258 0.0402580890226133 no 233 0.0122243942636362 39 5286025
SGTC_317 4495-0002 170 µM 2.24842567906359 0.040364445649602 no 234 0.0122745296369183 32 15991618
SGTC_1782 st039423 80.636 µM 2.23880975403932 0.0410180008360216 no 235 0.0125841486769784 25 2068169
SGTC_3028 9087778 49.47 µM 2.22904225581789 0.0416906177275808 no 236 0.0129055466917149 32 17217395
SGTC_3323 9138564 53.9225 µM 2.22496038991295 0.0419743404175432 no 237 0.0130419486718074 39 43912313 YNL103W MET4
SGTC_1339 1486-1321 22.7 µM 2.2238440577289 0.0420522061378359 no 238 0.0130794689973172 45 3469382
SGTC_1998 st075797 76.8 µM 2.21571312837826 0.0426228829645384 no 239 0.0133555776042377 36 24208315
SGTC_3352 9151559 45.5865 µM 2.20497689519661 0.043385990612052 no 240 0.0137278579437935 34 17159339
SGTC_180 1486-1293 102.781 µM 2.20004770505948 0.0437400222666607 no 241 0.0139017552847398 48 4140536
SGTC_800 3448-7362 155 µM 2.19487035844746 0.0441143833991691 no 242 0.0140864493235923 106 15991913
SGTC_3136 9095672 49.47 µM 2.1907353342294 0.0444152286436911 no 243 0.0142354752782109 38 17217380
SGTC_2258 7960471 200 µM 2.1881272516764 0.044605829367082 no 244 0.0143301671745872 34 2974708
SGTC_2909 7941780 10.49 µM 2.18707250416212 0.0446830980031415 no 245 0.0143686157530284 37 1243215
SGTC_2399 5884133 200 µM 2.18315973679019 0.0449706814480316 no 246 0.0145120243410753 52 722445
SGTC_1573 oleylamine 1.06 µM 2.1823931546486 0.0450271984266814 no 247 0.0145402645528032 34 5356789 An amine of the fatty acid oleic acid.
SGTC_1166 k206-0078 225 µM 2.18198491114065 0.04505731987799 no 248 0.0145553231765702 32 5404595
SGTC_1002 4049-0206 172 µM 2.17883795653823 0.0452900564607652 no 249 0.0146718540769095 54 4662749
SGTC_2649 anisomycin 9.56 µM 2.17041663691061 0.0459176236684297 no 250 0.0149876487918497 41 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3231 9132313 49.47 µM 2.14982713593936 0.047481425361843 no 251 0.0157844454424729 38 4905967
SGTC_2370 9071495 200 µM 2.14493119900725 0.0478594886397602 no 252 0.0159791741549171 41 21791103
SGTC_1725 st036284 20.55 µM 2.14148489530969 0.04812705393219 no 253 0.0161174776378169 38 707914
SGTC_194 1486-1323 56.904 µM 2.13626148503398 0.0485348713517594 no 254 0.0163290531668453 57 5178754
SGTC_2373 9071805 200 µM 2.13256360013347 0.0488252504641246 no 255 0.0164802709890335 34 10149009
SGTC_1298 1079-1278 263 µM 2.1319253902534 0.04887550656153 no 256 0.0165064902797888 38 2840950
SGTC_3066 9117245 49.47 µM 2.13055037390703 0.0489839232486365 no 257 0.0165631008199122 24 17176980
SGTC_1354 1498-1681 81 µM 2.13019356736654 0.0490120879493925 no 258 0.0165778179606406 54 5754243
SGTC_55 0767-0285 6.563 µM 2.1285936525338 0.0491385371160306 no 259 0.0166439470643397 46 3116166
SGTC_834 0312-0008 75.7 µM 2.1208993643647 0.0497502985198604 no 260 0.0169651360884711 45 6385573 YIL048W NEO1
SGTC_1730 st033808 45.1 µM 2.1195703241453 0.0498565813483425 no 261 0.0170211486594781 34 1045166
SGTC_2580 diallyl disulphide 81.36 µM 2.11784296658556 0.0499949880286981 no 262 0.0170941845574758 45 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1554 st069299 38.7 µM 2.1096786565505 0.0506533148697666 no 263 0.0174430220629126 44 24207999
SGTC_3167 9103034 49.47 µM 2.1052520459864 0.0510131293665237 no 264 0.0176346869818793 29 5127859
SGTC_1745 st081495 74 µM 2.10361177070807 0.0511469736527818 no 265 0.0177061631715112 81 13842402 YBL026W LSM2
SGTC_1620 st003704 16.5 µM 2.10326060337421 0.0511756647263114 no 266 0.017721497629196 45 2834414
SGTC_1781 st038725 66.3 µM 2.09798742484605 0.0516080357490768 no 267 0.0179531281205602 58 4270275 YIL048W NEO1
SGTC_927 2425-1185 123 µM 2.08907490487454 0.0523454100904059 no 268 0.0183504904763898 49 730375
SGTC_756 0508-1999 28.3 µM 2.08632591369673 0.0525745273102917 no 269 0.0184745554369295 53 6753853
SGTC_1770 st043884 66.3 µM 2.08215072831699 0.0529240336469405 no 270 0.0186643520886576 69 670149
SGTC_2943 9068529 45.32 µM 2.07445013099282 0.0535734852517985 no 271 0.0190187628239074 74 3270634
SGTC_185 k048-0037 25.491 µM 2.07012337803736 0.0539411551359062 no 272 0.019220396080311 23 6827589
SGTC_158 k038-0087 26.446 µM 2.068616583116 0.0540696644212701 no 273 0.0192910402671327 76 X158
SGTC_2975 9084847 53.72 µM 2.06651810200725 0.0542490401671566 no 274 0.0193897924778098 51 27211724
SGTC_340 k038-0059 454 µM 2.06158023466612 0.0546729809588342 no 275 0.019623858705362 40 23733424
SGTC_976 1348-1067 47.6 µM 2.05898820818987 0.0548965655401857 no 276 0.0197476840560547 48 5310671 YGL099W LSG1
SGTC_398 bronopol 33.3 µM 2.0543636578788 0.0552972669370458 no 277 0.0199702538678775 62 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_772 k072-0172 35.3 µM 2.05232062689105 0.0554750225838334 no 278 0.0200692563391104 33 5861980
SGTC_1822 st052468 42 µM 2.04647127271684 0.0559864460726349 no 279 0.0203550130209257 32 2873678
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 2.03436999578246 0.057056291358835 no 280 0.0209571523388311 45 5377381
SGTC_2525 harmine 47.85 µM 2.03407063524862 0.0570829596971104 no 281 0.0209722370839821 35 5280953 A monoamine oxidase inhibitor
SGTC_3180 9109287 49.47 µM 2.02741608489707 0.0576783131120151 no 282 0.02130993916733 70 18891271
SGTC_105 0111-0055 734.78 µM 2.02487842879065 0.0579066279682966 no 283 0.0214399245610344 33 5179370
SGTC_1080 nisoldipine 24.4 µM 2.02460821440028 0.0579309811547556 no 284 0.0214538050530102 54 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_195 4234-0266 16.654 µM 2.02416488152566 0.0579709541560677 no 285 0.0214765948273671 73 2303354
SGTC_1558 st069300 45.6 µM 1.99261382708683 0.0608718276119858 no 286 0.0231518749608375 51 24208000
SGTC_2546 rhodinyl acetate 100 µM 1.98564293297857 0.0615278041405026 no 287 0.0235364928601149 54 6708682
SGTC_604 1000-0114 314 µM 1.9826741017368 0.0618088485325574 no 288 0.0237019221194533 37 1572745
SGTC_1433 4060-0023 7.6 µM 1.98248778445969 0.0618265196191508 no 289 0.0237123366175642 56 3840627
SGTC_1410 3909-8106 77.9 µM 1.97674480675736 0.062373143435286 no 290 0.0240352416482633 47 1039210
SGTC_140 0062-0056 502.533 µM 1.97651451407086 0.0623951413223527 no 291 0.0240482667723696 44 3758964
SGTC_3145 9085516 49.47 µM 1.9733025958169 0.0627025793243139 no 292 0.0242305486811112 63 25236195
SGTC_2496 diffractaic acid 79.83 µM 1.97040773317611 0.0629806797989139 no 293 0.0243958300061454 61 94870 An apoptosis inducer which activates caspases.
SGTC_1814 st052110 31.539 µM 1.9664837948792 0.0633591730875171 no 294 0.0246213762125004 54 674163
SGTC_2365 9042475 200 µM 1.96432234826554 0.0635684158286811 no 295 0.0247463607978199 55 6464479
SGTC_2329 6138490 200 µM 1.9598193123006 0.0640060670822467 no 296 0.0250084565779891 64 720019
SGTC_681 1642-0006 26.6 µM 1.95221350930383 0.064750593163474 no 297 0.0254564304753294 51 4446530
SGTC_1318 1280-3875 124 µM 1.93875331754653 0.0660846615015563 no 298 0.0262656914736092 55 373245
SGTC_88 0180-0332 8.668 µM 1.93630819774661 0.066329271934225 no 299 0.0264149826843561 56 3101745
SGTC_438 sphingosine 6.67 µM 1.93581193110853 0.0663790040654009 no 300 0.02644536955315 35 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_154 3389-1638 511.116 µM 1.9351122755153 0.0664491673571382 no 301 0.0264882597355139 52 5238686
SGTC_205 1486-1330 71.903 µM 1.93452244922769 0.0665083612729275 no 302 0.0265244623181369 52 4118834
SGTC_1670 st016595 4.04 µM 1.93433490178514 0.0665271917512437 no 303 0.026535982335481 49 597879
SGTC_1126 isoteolin 1.0172 µM 1.92794390925976 0.0671713414863102 no 304 0.0269310516660774 51 133323
SGTC_1293 1000-1278 195 µM 1.92052477716271 0.0679251545140315 no 305 0.027395823275677 61 678847
SGTC_570 0987-0065 62.6 µM 1.91712928548128 0.0682723214042883 no 306 0.0276107544853141 52 3104428
SGTC_837 0091-0265 12.5 µM 1.91067529421402 0.0689359730042657 no 307 0.0280231608233441 67 759367
SGTC_2082 5219693 150 µM 1.90945744279376 0.0690617581947337 no 308 0.028101553327975 47 2834649
SGTC_1567 st069303 68.4 µM 1.90804977012063 0.0692073692800033 no 309 0.028192391950483 75 5581319
SGTC_2606 farnesol 9.78 µM 1.89785354583652 0.0702691483681826 no 310 0.0288576886311551 80 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_497 capsazepine 133 µM 1.89719540326434 0.0703381117842218 no 311 0.0289010766583023 52 2733484 A calcium channel blocker.
SGTC_3229 9132204 49.47 µM 1.89286773225932 0.0707928833677525 no 312 0.0291877306743628 29 17682924
SGTC_3052 9092717 49.47 µM 1.89178878858059 0.0709066148019825 no 313 0.0292595638363558 63 25237534
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.8694209178081 0.0732961532559643 no 314 0.030782138299391 69 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1920 st075728 45.7 µM 1.86272824238983 0.0740229681453499 no 315 0.0312502551363693 66 3400306
SGTC_1726 st035556 14.5795 µM 1.85959107219871 0.0743655500364678 no 316 0.0314717016975869 47 5919439
SGTC_2749 bexarotene 57.39 µM 1.85504548906538 0.0748640779929252 no 317 0.0317948654856586 57 82146 An retinoic acid receptor inhibitor.
SGTC_219 mitoxanthrone 164.414 µM 1.84717680862786 0.0757330811646897 no 318 0.0323607596895135 67 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_598 3937-0236 20.2 µM 1.84565368411268 0.0759021764352102 no 319 0.0324712531319508 61 1379313
SGTC_3283 9109332 35.8195 µM 1.84101771000977 0.0764186255848796 no 320 0.0328094817279659 48 17027281
SGTC_853 0419-0306 21 µM 1.83794690617613 0.0767621833501633 no 321 0.0330351146553861 84 762713
SGTC_2782 7736369 71.43 µM 1.83460316408418 0.0771376113783849 no 322 0.0332822547634816 74 2950836 YOL077C BRX1
SGTC_3000 9075062 71.4286 µM 1.83248862213515 0.077375746648352 no 323 0.0334393276795702 71 17057871
SGTC_2964 9083345 53.42 µM 1.83094052834657 0.0775504434700737 no 324 0.0335547101221712 78 17741579
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.82852269322892 0.0778238864018189 no 325 0.0337355715225616 74 5024745
SGTC_2663 amphotericin b 100 µM 1.82407014883966 0.0783293566662143 no 326 0.034070733882784 85 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2308 7584454 197.62 µM 1.82105919015666 0.0786725808637161 no 327 0.0342989299407795 83 893577
SGTC_2726 cimetidine 79.27 µM 1.8204518037649 0.07874195579168 no 328 0.0343451147694683 49 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2015 5119600 184 µM 1.81710573199418 0.0791249713532358 no 329 0.0346004626291747 80 2828786
SGTC_1474 0330-0125 5.35 µM 1.80821504467204 0.0801495168297392 no 330 0.0352865189966863 52 X1474
SGTC_67 0335-0847 266 µM 1.80723042950286 0.0802635959273205 no 331 0.0353631791212594 95 4552207 YOR254C SEC63
SGTC_1260 0700-1617 7.75 µM 1.80196780854511 0.0808754132542578 no 332 0.0357752352369411 66 2853078
SGTC_1791 st048313 56.1 µM 1.79592826455024 0.081581884775524 no 333 0.0362529632866424 49 1204976
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.79311111615287 0.0819130059399149 no 334 0.0364775792663512 71 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_355 1311-2252 105 µM 1.79002851000056 0.0822764877142689 no 335 0.0367246641202459 69 5338538
SGTC_721 1187-1332 279 µM 1.78948775744615 0.0823403749368163 no 336 0.0367681486916003 65 25730
SGTC_170 4197-0004 226 µM 1.78891661293106 0.0824078933751098 no 337 0.0368141229452183 79 218692
SGTC_2720 fluspirilene 36.88 µM 1.78788802560586 0.0825295940117099 no 338 0.036897037593671 51 3396 An atypical antipsychotic.
SGTC_458 nppb 133 µM 1.784817074595 0.0828937484743392 no 339 0.0371454964290147 42 4549 A chloride channel blocker.
SGTC_2414 st077232 92.9 µM 1.78301393168386 0.0831081283154935 no 340 0.037292017754499 60 729801
SGTC_1442 4112-3290 3 µM 1.7821183007602 0.0832147668112643 no 341 0.037364971015277 55 704353
SGTC_2896 9052656 71.43 µM 1.78195828628959 0.0832338297974762 no 342 0.0373780171967271 99 6469436
SGTC_1932 st074806 40.9 µM 1.77846890942755 0.0836503462275876 no 343 0.0376634369142425 77 17251235
SGTC_1473 k844-0725 134 µM 1.77731050009866 0.0837889677336057 no 344 0.0377585835048488 86 54682906
SGTC_2068 5226020 147 µM 1.77501540060789 0.0840641211883659 no 345 0.0379476721636519 75 1810509
SGTC_2089 5281248 129.67 µM 1.77352452204022 0.084243221823358 no 346 0.0380709160965584 71 2737878
SGTC_92 0063-0024 660.874 µM 1.77018516319101 0.0846454210349672 no 347 0.0383481500578948 57 3594437
SGTC_1291 0993-0025 5.79 µM 1.76969841225321 0.084704166374413 no 348 0.0383886972727012 63 4353356
SGTC_2126 5251174 33.877 µM 1.76967902396382 0.0847065069549483 no 349 0.0383903130750297 71 790722
SGTC_705 1124-0212 310 µM 1.76713160226397 0.0850144571708864 no 350 0.0386030955489779 84 9554485
SGTC_758 0868-0029 16 µM 1.76494792134022 0.0852791031702298 no 351 0.0387862593603713 50 762687
SGTC_3117 9124945 49.47 µM 1.76201219850306 0.0856358631082216 no 352 0.0390336182427889 50 17592065
SGTC_2785 7756463 72.73 µM 1.75460432457811 0.0865410613979531 no 353 0.0396635056190025 90 2201551
SGTC_1124 fisetin 1.16336 µM 1.75394521468355 0.0866219459366741 no 354 0.0397199475195895 70 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1727 st034309 9.9045 µM 1.75223215680134 0.0868324329503803 no 355 0.0398669481739182 94 870305
SGTC_27 0485-0001 32.618 µM 1.73791200802475 0.0886069507490193 no 356 0.0411131597457263 62 2054479
SGTC_2826 7992541 19.48 µM 1.73615474817913 0.088826553542685 no 357 0.0412682380560024 75 2985066
SGTC_3227 9130768 49.47 µM 1.73445241256155 0.0890396787192046 no 358 0.0414189211523 52 17720899
SGTC_1302 1159-0335 255 µM 1.73305438004755 0.0892149908916978 no 359 0.0415430018808648 62 649284
SGTC_536 3852-0578 10.6 µM 1.73130522578903 0.0894346949925471 no 360 0.0416986699465534 71 2869208
SGTC_3091 9116372 49.47 µM 1.7270409134336 0.0899720038843888 no 361 0.0420801579633688 67 17169793
SGTC_271 rotenone 740 µM 1.71931907478161 0.0909510641499182 no 362 0.0427781442776288 59 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_731 3966-0296 387 µM 1.71717171013971 0.0912247302794304 no 363 0.0429739014253761 62 660956
SGTC_2358 9037157 4 µM 1.71646300154989 0.0913151839519765 no 364 0.0430386670525104 86 2388925
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.71502003351838 0.0914995578816826 no 365 0.0431707770067188 72 688761
SGTC_197 4544-0043 41.561 µM 1.71415736911343 0.0916099157403263 no 366 0.0432499139700826 94 896523
SGTC_84 0443-0269 128.823 µM 1.70533898710577 0.0927436848957367 no 367 0.0440656101592293 68 6150058
SGTC_176 1486-1328 72.834 µM 1.70216609905539 0.0931541476881427 no 368 0.0443621179251093 96 22310231
SGTC_1902 st060212 70.5 µM 1.69989873655347 0.0934482879578748 no 369 0.0445749873120374 75 688944
SGTC_1719 st032227 49.2 µM 1.69873030537914 0.093600133714902 no 370 0.0446850053028167 82 3125804
SGTC_209 4077-0173 175.592 µM 1.69634220738636 0.0939110502617922 no 371 0.0449105458047386 42 15993494
SGTC_3203 9113543 49.47 µM 1.69022014163701 0.0947115883448327 no 372 0.045492923194746 94 17018012
SGTC_2565 isoliquiritigenin 100 µM 1.68543480066944 0.0953408262272382 no 373 0.0459523570598719 81 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1107 amlodipine 47 µM 1.68111416675343 0.095911597549686 no 374 0.0463703705936278 63 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1030 k029-0042 36.7 µM 1.67603105488269 0.0965863076815639 no 375 0.0468660549494262 73 6080581
SGTC_782 0083-0095 30.5 µM 1.67191657007528 0.0971349947618632 no 376 0.0472703874182508 74 3591729 An indicator and reagent.
SGTC_1413 3910-0535 34.4 µM 1.66951950549003 0.0974557080125195 no 377 0.0475072340227162 80 2876951
SGTC_1563 conessine 56.1 µM 1.66791921150026 0.097670249930457 no 378 0.0476658826940983 48 441082 An anti-amoebic, histamine inhibitor.
SGTC_1947 st076332 61.6 µM 1.66682141007242 0.0978176257839126 no 379 0.0477749608264805 72 24208416
SGTC_2820 7989630 71.43 µM 1.65969375509377 0.0987784541489575 no 380 0.0484880381604125 45 2984098
SGTC_1462 k081-0014 26.5 µM 1.65912909079597 0.0988548667359678 no 381 0.0485448912034453 58 3270634
SGTC_2581 avocatin a 64 µM 1.65456539642349 0.0994740316568664 no 382 0.0490063437991544 76 6710728 A skin care supplement.
SGTC_1646 st011709 75.6 µM 1.65299531046401 0.099687702124796 no 383 0.049165908990899 90 5757843
SGTC_825 1988-2224 89.6 µM 1.65007793721637 0.100085612810723 no 384 0.0494634983025537 95 1180859
SGTC_1408 3909-7976 48.8 µM 1.6496214931124 0.100147973575043 no 385 0.0495101881008177 72 24152374
SGTC_392 N-ethylmaleimide 8.33 µM 1.6477283633343 0.100406921463558 no 386 0.0497042124998936 94 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_923 1900-2434 73.3 µM 1.64545094423241 0.100719080575921 no 387 0.0499384255567688 103 5910570
SGTC_1398 3558-0053 112 µM 1.63968042644822 0.101513195917017 no 388 0.0505358153976941 49 4532369
SGTC_1979 st071809 45.3 µM 1.63664107368926 0.10193328822693 no 389 0.0508527440436023 77 4976333
SGTC_1471 k673-0312 37 µM 1.63259756551472 0.102494131877676 no 390 0.0512768317972657 70 24099884
SGTC_1694 st024011 44.9 µM 1.6323100790154 0.102534092158574 no 391 0.0513070905240573 83 2787533
SGTC_2897 9048598 12.99 µM 1.6316359162743 0.102627844397132 no 392 0.0513781036763314 48 6467404
SGTC_1340 1486-1359 257 µM 1.62929869549716 0.102953351745022 no 393 0.0516249010935458 86 4309068
SGTC_633 0437-0093 97.7 µM 1.62929678569919 0.102953618031045 no 394 0.0516251031422234 79 2831118
SGTC_2400 5203494 178.7 µM 1.61344893622066 0.105180569994328 no 395 0.0533235043565494 111 6777674
SGTC_2984 9022109 38.96 µM 1.61263427694386 0.105295981285596 no 396 0.0534119934989152 88 6459207
SGTC_2265 7929201 200 µM 1.6106915584338 0.105571572361174 no 397 0.0536234832634933 87 1265108
SGTC_757 1066-0008 322 µM 1.60806241341181 0.10594536892709 no 398 0.0539107550528798 85 6842497
SGTC_2662 daunorubicin 22.37 µM 1.60801147333773 0.105952620723947 no 399 0.0539163329954039 97 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_991 3996-0057 64.7 µM 1.60660989925048 0.10615228865791 no 400 0.0540699847959964 82 715343
SGTC_2620 irigenin 100 µM 1.6046918735623 0.106425970482942 no 401 0.0542808156079509 106 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1519 esterone 74 µM 1.60398336181474 0.106527196309745 no 402 0.0543588600585488 85 698 A steroid.
SGTC_2159 5658611 73.75 µM 1.59833669020703 0.107336427435046 no 403 0.0549840330416283 81 793844
SGTC_1038 k292-0204 154 µM 1.59454644378472 0.107882091962889 no 404 0.0554068485233269 82 4454212
SGTC_3125 9127534 49.47 µM 1.59445954966394 0.107894625096936 no 405 0.0554165718901449 60 1639235
SGTC_2075 5212009 200 µM 1.59438376533688 0.107905556670981 no 406 0.055425053181838 70 780898
SGTC_2161 5662504 8.5105 µM 1.59287499805889 0.108123356111487 no 407 0.0555941180596998 85 2859334
SGTC_3041 9091929 49.47 µM 1.59210394359231 0.108234784479 no 408 0.0556806755795791 84 25236887
SGTC_1889 st059080 5.18 µM 1.59043334364812 0.108476493482845 no 409 0.0558685796907587 67 176925 Isolated from Daphnopsis sellowiana.
SGTC_1243 0416-0003 5.65 µM 1.58842106157948 0.108768153711307 no 410 0.0560955790109347 85 2141977
SGTC_2295 7971645 200 µM 1.58808929277203 0.108816294391044 no 411 0.0561330745730768 68 2978226 YKL099C UTP11
SGTC_485 niflumic acid 177 µM 1.58778693934182 0.108860180149718 no 412 0.0561672629036382 71 4488 A COX2 inhibitor.
SGTC_2236 dapsone 200 µM 1.58606381532615 0.109110529721884 no 413 0.056362417059388 52 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_96 0929-0093 37.281 µM 1.58435875709439 0.109358661550198 no 414 0.0565560508662375 102 6991579
SGTC_3286 9117135 37.221 µM 1.58430485179732 0.109366512825219 no 415 0.0565621811226769 82 3438150
SGTC_475 α-linolenic acid 10 µM 1.58358189604401 0.109471850039935 no 416 0.0566444482181143 99 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_583 1488-1091 88.9 µM 1.58100466292516 0.109847954856426 no 417 0.0569384857855827 108 4303273
SGTC_625 k213-0058 121 µM 1.58059414419955 0.109907948840084 no 418 0.0569854328014858 130 3655420
SGTC_3341 9147222 25.867 µM 1.57541940721748 0.110666211730741 no 419 0.0575798338333637 86 1939759
SGTC_468 gf-109203x 121 µM 1.57406430767164 0.110865394720093 no 420 0.0577362915539381 42 2396 A protein kinase C inhibitor.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.57184489596043 0.111192175549672 no 421 0.0579932632956629 94 616764
SGTC_2247 cerulenin 830 nM 1.56881630069504 0.111639210434463 no 422 0.0583453745239902 78 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_3250 9135583 49.47 µM 1.56782437459905 0.111785902536772 no 423 0.0584610623941978 82 7699353
SGTC_2698 st077697 67.5 µM 1.56776828577046 0.111794201412326 no 424 0.0584676093845728 84 3154499
SGTC_1463 k081-0032 34.1 µM 1.56577062229187 0.112090062107407 no 425 0.0587011630692243 74 977755
SGTC_273 hydroxyurea 18.1 mM 1.56352319343212 0.112423582488247 no 426 0.0589647923590716 112 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2543 pimpinellin 60.67 µM 1.56305102454905 0.112493742789791 no 427 0.0590202969042412 85 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1441 4106-0040 13 µM 1.55828370482903 0.113203878783659 no 428 0.0595830050132001 88 2904180
SGTC_747 3448-8087 38.7 µM 1.55558295687025 0.113607596276608 no 429 0.0599036470134146 88 5168703
SGTC_1864 st057645 30.4 µM 1.55408321706253 0.11383222552394 no 430 0.0600822839655685 85 688666
SGTC_678 1218-2179 85.9 µM 1.55392381066896 0.113856119820724 no 431 0.0601012956713563 76 6820081 YOR116C RPO31
SGTC_1859 st055998 20 µM 1.54749506273734 0.114822740418471 no 432 0.0608719570523562 89 676301
SGTC_2917 7979103 53.79 µM 1.54505292623671 0.115191463605856 no 433 0.0611667309841374 84 2980565
SGTC_1204 4049-0315 18.3 µM 1.54410681566333 0.115334537017184 no 434 0.0612812289980391 82 588402
SGTC_992 3909-8734 162 µM 1.54150707838156 0.115728326577868 no 435 0.0615967107655208 83 4288319
SGTC_1481 3346-2004 36 µM 1.53689028678431 0.116429996944043 no 436 0.0621600892544301 109 2770522
SGTC_1648 st011736 69.8 µM 1.53551007003555 0.116640350145779 no 437 0.0623292927169119 81 2855514
SGTC_3269 9137823 49.47 µM 1.53372064148976 0.116913470634006 no 438 0.0625491967201516 56 17682936
SGTC_1282 0886-0010 32.4 µM 1.53115357634202 0.117306072854219 no 439 0.0628657205878538 113 2836211 YNL267W PIK1
SGTC_3040 9091894 49.47 µM 1.52547979513956 0.118177120822917 no 440 0.0635697346747185 68 25236966
SGTC_650 1328-0195 38 µM 1.52540769348534 0.118188219336985 no 441 0.0635787205069998 92 2780821
SGTC_541 4513-1321 94 µM 1.52452234496433 0.118324559980009 no 442 0.0636891396738657 118 747515
SGTC_2750 bromebric acid 70.15 µM 1.52254681305657 0.118629185906147 no 443 0.0639360624983622 94 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2097 5376186 200 µM 1.51812497141571 0.119313038651768 no 444 0.0644914485562417 96 742755
SGTC_314 1671-0008 2.74 µM 1.51728777847515 0.11944282596977 no 445 0.0645970212486187 109 3913060
SGTC_1212 0520-0165 585 µM 1.51680882652322 0.119517121122659 no 446 0.0646574789510061 97 5403258
SGTC_2108 5365811 200 µM 1.51527229505346 0.119755688327845 no 447 0.064851730694818 99 780283
SGTC_2539 epi(13)torulosol 80 µM 1.51049983797823 0.12049881713718 no 448 0.0654579653471235 98 6708597
SGTC_270 tamoxifen 5.46 µM 1.50958127026848 0.120642221018399 no 449 0.0655751517546807 106 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_941 3237-0776 460 µM 1.50297353605832 0.121677340879286 no 450 0.0664229342059026 77 760008
SGTC_1037 k284-1091 78.7 µM 1.50248810568416 0.121753630239312 no 451 0.0664855487375433 93 3334711
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.50051193880285 0.122064547928796 no 452 0.066740921640473 97 5106787 A p450 inhibitor.
SGTC_3246 9135460 32.98 µM 1.4988043901345 0.122333651594185 no 453 0.0669621926874927 94 41446951
SGTC_582 0987-0078 156 µM 1.49840989694148 0.12239588150361 no 454 0.067013393309214 101 1625765
SGTC_1425 4048-4433 7.33 µM 1.49317757785796 0.12322336333357 no 455 0.0676953548770298 111 23734946
SGTC_1513 0337-0559 19 µM 1.48958977164931 0.123793029311493 no 456 0.0681660665284526 88 775073
SGTC_1177 0983-0204 23.6 µM 1.48642456697574 0.124297123838968 no 457 0.0685834278419876 108 766818
SGTC_1748 st037455 53.6035 µM 1.48263714791995 0.124902197578056 no 458 0.0690854209201793 108 580690
SGTC_1755 st041960 45.185 µM 1.48063358514558 0.125223115397312 no 459 0.0693521203381828 117 2257073
SGTC_644 1498-1197 63.3 µM 1.48048469313089 0.125246986925505 no 460 0.0693719713523072 104 6741615
SGTC_1397 3532-0190 20.1 µM 1.4770621107284 0.125796598141551 no 461 0.0698294944144412 69 5322280
SGTC_247 mechlorethamine 29.705 µM 1.4757951378075 0.126000479448484 no 462 0.0699994482104473 73 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_896 0964-0007 44.5 µM 1.47490501018718 0.126143856527477 no 463 0.0701190415835671 107 6756758
SGTC_2793 7325131 81.82 µM 1.4733420369998 0.126395887122017 no 464 0.0703294155375785 101 4176441
SGTC_2369 9071472 200 µM 1.46838267614128 0.12719790974153 no 465 0.0710001523145685 79 17296037
SGTC_1372 2752-0194 270 µM 1.46777961964809 0.127295676318011 no 466 0.07108204758451 83 823334
SGTC_713 1488-1073 324 µM 1.46677180925962 0.127459177611135 no 467 0.0712190704521171 92 3312542
SGTC_2174 5790901 200 µM 1.46460656497429 0.127810948023186 no 468 0.0715141449213102 107 786020
SGTC_2675 theaflavin digallate 100 µM 1.46078279824723 0.128433812321667 no 469 0.0720375289971341 110 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2293 7624732 200 µM 1.45541758856428 0.129311314221598 no 470 0.0727768450220836 107 894453
SGTC_1668 st014914 51.6 µM 1.45523660683527 0.129340986792192 no 471 0.0728018848849371 112 2839556
SGTC_672 1441-0018 53.7 µM 1.44751156384156 0.130611934984293 no 472 0.0738768500307736 84 251141
SGTC_1288 0973-0013 65.5 µM 1.44737085418143 0.130635164773097 no 473 0.0738965421213266 102 4315430
SGTC_2445 5742597 35.57 µM 1.44652064553135 0.130775586679811 no 474 0.0740156128039333 126 1774255
SGTC_229 benomyl 22.8748 µM 1.44448262186407 0.131112614822873 no 475 0.0743016323054283 104 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1390 3413-2614 145 µM 1.44434869783859 0.131134782840204 no 476 0.0743204569300587 131 3421432
SGTC_3207 9114163 49.47 µM 1.44262801153241 0.131419832899354 no 477 0.0745626440840495 132 849233
SGTC_2571 chrysanthemic acid 100 µM 1.44165245354981 0.13158163438137 no 478 0.074700221513461 107 2743 An insecticide.
SGTC_1692 fluoroquinolonic acid 71 µM 1.43718656263112 0.132324081179927 no 479 0.0753324950457108 92 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1641 st009299 47.1 µM 1.4368098279858 0.132386844478872 no 480 0.075386018537024 111 4046054
SGTC_1430 4049-0248 69.1 µM 1.43674920835287 0.132396945514125 no 481 0.0753946336035436 103 22774488
SGTC_2207 7258803 200 µM 1.43575436196123 0.132562792422066 no 482 0.0755361251906757 97 3666799
SGTC_1470 k295-0292 231 µM 1.43187676723361 0.133210576724401 no 483 0.0760895461367602 114 5045612
SGTC_1852 st056254 31.4 µM 1.4295331125403 0.133603158101681 no 484 0.0764255323807418 92 442583
SGTC_1334 1486-0610 236 µM 1.42441682749363 0.13446293974277 no 485 0.0771629229469096 109 3742339
SGTC_343 4130-2827 29.8 µM 1.42302650470813 0.13469723569008 no 486 0.0773642359804089 96 1118244
SGTC_123 0083-0120 66.675 µM 1.41746028771563 0.135638054719008 no 487 0.0781741985646033 122 16001701
SGTC_1259 0671-0132 43 µM 1.41492950831026 0.136067300006545 no 488 0.0785445825775409 101 X1259
SGTC_226 1,3-diallylurea 8.28947 mM 1.41397083936673 0.136230142333112 no 489 0.0786852323142789 105 74537 YKL182W FAS1
SGTC_1769 st044406 64.4 µM 1.4112037747787 0.136700911830375 no 490 0.0790922687304552 141 670903
SGTC_220 paclitaxel 373.376 µM 1.40737771576422 0.137353681766523 no 491 0.0796577077416423 87 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_206 4546-0025 72.014 µM 1.40458850625314 0.137830892578157 no 492 0.0800718381973168 111 6620745 YIL048W NEO1
SGTC_2597 laccaic acid a 100 µM 1.40368690900428 0.137985390090632 no 493 0.0802060511932693 108 5491415 A textile dye.
SGTC_371 0195-0006 7.36 µM 1.40272279621251 0.138150730898039 no 494 0.0803497583890435 110 3928593
SGTC_53 0973-0023 39.979 µM 1.4026999082312 0.138154657720038 no 495 0.0803531723522162 107 674768
SGTC_3189 9110682 49.47 µM 1.40069511000558 0.138498910226565 no 496 0.0806526328077534 107 17122418
SGTC_3192 9110362 49.47 µM 1.39993024216256 0.13863040288102 no 497 0.0807671044080058 98 16649480
SGTC_2040 5100729 123 µM 1.39833699076758 0.138904580548856 no 498 0.0810059473619452 109 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1498 4478-3555 97.6 µM 1.39760285517201 0.139031039835665 no 499 0.0811161802489236 72 3437919
SGTC_2239 6685329 187.64 µM 1.39570939357689 0.139357561681081 no 500 0.0814010122135498 86 805680
SGTC_1314 1222-0010 41.1 µM 1.39112807553282 0.140149753306986 no 501 0.082093296315701 100 3526027
SGTC_1588 farnesol 29.9 µM 1.38878270631944 0.140556491184257 no 502 0.082449417757589 113 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_939 1165-0479 45.3 µM 1.3881276480506 0.140670235500807 no 503 0.0825490894576357 103 1377347
SGTC_2879 9041815 71.43 µM 1.38706844914845 0.140854286932357 no 504 0.0827104458420602 71 4942971
SGTC_646 4092-0839 27.3 µM 1.38681593841812 0.140898188501719 no 505 0.0827489478690494 126 877796
SGTC_2854 9024559 71.43 µM 1.38399047985091 0.14139005635786 no 506 0.0831806849101449 97 3163529
SGTC_954 1189-0853 2.85 µM 1.38337962123071 0.141496550041267 no 507 0.0832742478967512 113 2828194
SGTC_1396 3511-0007 98.6 µM 1.38235002950336 0.141676166296866 no 508 0.0834321257361948 111 X1396
SGTC_2306 7482397 179.52 µM 1.37288913591229 0.143333885146502 no 509 0.0848934072450004 123 891448
SGTC_1169 aniline yellow 25.8 µM 1.37229194344987 0.143438961710114 no 510 0.0849862863340176 109 6051 A DNA damaging agent.
SGTC_2155 5570423 76 µM 1.37040846675273 0.143770701769211 no 511 0.0852797152921741 113 797402
SGTC_1020 4335-0961 93.3 µM 1.36173423716473 0.145305187410242 no 512 0.0866408861122606 120 669075
SGTC_1424 4048-1941 275 µM 1.3611039349913 0.145417116731634 no 513 0.0867404231548004 113 X1424
SGTC_441 propafenone 146 µM 1.35837364397103 0.145902632509343 no 514 0.0871725764719025 129 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3138 9097216 49.47 µM 1.35793732066199 0.14598032282232 no 515 0.087241786918904 121 25237486
SGTC_2651 TUB2.036 5 µM 1.3541663562996 0.146652926616839 no 516 0.0878416549700562 140 15992207 YFL037W TUB2
SGTC_2983 9022671 12.99 µM 1.35220409645527 0.147003744213983 no 517 0.0881550168039027 111 6405161
SGTC_432 NS 1619 61.3 µM 1.35124316029071 0.147175747836712 no 518 0.0883087765195024 110 4552 A K+/calcium channel activator.
SGTC_2411 st077133 39.94 µM 1.35017283230263 0.147367490915919 no 519 0.0884802752513188 126 1403142 YNL221C POP1
SGTC_550 4123-0385 25.7 µM 1.34838661983815 0.147687853213447 no 520 0.0887670326053209 119 5731123
SGTC_502 l-744,832 89.3 µM 1.34548576116173 0.148209123630997 no 521 0.0892342082356824 103 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2691 st077356 60.2 µM 1.34229463620123 0.148783973760658 no 522 0.0897502409490914 130 2839272
SGTC_841 0251-0215 91.2 µM 1.33735520137564 0.14967669960992 no 523 0.090553360083397 119 3888614
SGTC_1674 st016616 23.6 µM 1.33647057961172 0.149836957759891 no 524 0.0906977552310436 110 625830
SGTC_3338 9144300 39.5675 µM 1.33320272356238 0.150429954780099 no 525 0.091232642909425 101 4901274
SGTC_594 1487-1584 10.8 µM 1.33213707672621 0.150623668533248 no 526 0.0914075743665844 131 5013332
SGTC_166 k072-0058 166.424 µM 1.32498330470028 0.151928383940331 no 527 0.0925883443827026 133 5846229
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.32404845813463 0.152099435625525 no 528 0.0927434758213911 128 688662
SGTC_2460 5552655 174.22 µM 1.32207423543003 0.152461085160096 no 529 0.0930717161199057 143 5401989
SGTC_2345 9052315 157.45 µM 1.32152887637664 0.152561087695551 no 530 0.0931625403581288 123 6469265
SGTC_977 1348-1378 135 µM 1.32023044927898 0.152799355505825 no 531 0.093379044323547 131 X977
SGTC_2981 9013952 38.96 µM 1.31287336417438 0.15415407580553 no 532 0.0946128117886464 109 2996344
SGTC_1111 tnp00062 510.699 nM 1.31058023323814 0.154577947916406 no 533 0.0949998105186123 112 676306
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.30951503381845 0.154775105693606 no 534 0.0951799743135058 159 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1583 clindamycin 39.6 µM 1.30922865253853 0.154828140333858 no 535 0.0952284546472997 127 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_776 4476-4378 112 µM 1.30750980967329 0.155146703214835 no 536 0.0955198127553987 118 2892008
SGTC_2732 terfenadine 20 µM 1.30450159285308 0.155705273725357 no 537 0.0960313083898998 126 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_620 0109-0052 432 µM 1.29868002832363 0.156789993195813 no 538 0.0970268803955022 134 493037
SGTC_3291 9121177 71.43 µM 1.29826009209541 0.156868430836752 no 539 0.097098987464613 101 17015612
SGTC_1489 4065-0444 182 µM 1.29785692573786 0.156943760412228 no 540 0.0971682519847251 115 2877968
SGTC_196 k015-0023 18.111 µM 1.29569110035087 0.157348841077906 no 541 0.0975409643518486 92 5211998
SGTC_1145 3546-0597 10.2 µM 1.29472980705395 0.157528854607926 no 542 0.0977067268442754 111 875334
SGTC_2915 7971052 15.16 µM 1.29413599917391 0.157640119741858 no 543 0.0978092244089624 97 5741558
SGTC_100 0086-0128 49.5915 µM 1.293423750585 0.157773645869402 no 544 0.0979322700424981 127 93297
SGTC_2110 5483698 200 µM 1.29094748554685 0.158238452281327 no 545 0.0983609439352438 115 2848765 YHR062C RPP1
SGTC_537 1334-0398 209 µM 1.29044316172202 0.158333226226171 no 546 0.0984484171680656 133 5846986
SGTC_1472 k841-0093 193 µM 1.29012400923897 0.158393221491382 no 547 0.0985038024891353 122 X1472
SGTC_1341 1486-1360 280 µM 1.28902584268401 0.158599772145231 no 548 0.098694551227343 129 3976547
SGTC_1326 1431-2094 10.8 µM 1.28747890858241 0.158891029567137 no 549 0.0989637081844264 135 616278
SGTC_895 0964-0006 13.7 µM 1.2871041190188 0.158961647827959 no 550 0.0990289999844603 162 6738897
SGTC_1676 st018489 23.4 µM 1.28534104010171 0.159294124988326 no 551 0.099336567379414 115 3696235
SGTC_2006 4011487 200 µM 1.28262450632409 0.159807293091328 no 552 0.0998118301182173 145 45595294
SGTC_433 pimozide 108 µM 1.28179202925117 0.159964768822848 no 553 0.0999578055228133 110 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1060 3448-7350 82 µM 1.28080764980361 0.160151110112152 no 554 0.100130618213212 128 570178
SGTC_2448 5185112 27.17 µM 1.28062461869895 0.160185773216373 no 555 0.100162774264988 113 5718189
SGTC_2477 5967686 25.23 µM 1.27933674029325 0.160429815023894 no 556 0.100389249983845 122 776118
SGTC_85 0868-0259 160.055 µM 1.27838068133179 0.160611136943908 no 557 0.100557616168209 121 83173
SGTC_142 0335-0849 62.6745 µM 1.27679471653776 0.160912219100775 no 558 0.100837365671826 145 3889043 YPR107C YTH1
SGTC_2217 6934799 96.0675 µM 1.27652107995415 0.160964203962212 no 559 0.100885689977783 119 675606
SGTC_3146 9095609 49.47 µM 1.27498674266184 0.161255896935242 no 560 0.101156967222902 119 17173999
SGTC_397 arbidol 50 µM 1.27172824446726 0.161876513271121 no 561 0.101734845804535 116 131410 A RNA synthesis inhibitor.
SGTC_1862 st057513 3.81 µM 1.27098597786866 0.162018103332599 no 562 0.101866818560201 129 5393163
SGTC_264 promethazine 12.5 mM 1.27014153635671 0.16217928168826 no 563 0.102017109171868 166 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_292 k038-0015 474 µM 1.266376343634 0.162899213275857 no 564 0.102689188098302 127 46368540
SGTC_492 tmb-8 126 µM 1.26528992232254 0.163107330452298 no 565 0.102883708900467 113 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_452 diindolylmethane 8 µM 1.26294465602328 0.163557183553845 no 566 0.103304534955909 116 3071 Inhibits expression of several cancer promoting factors.
SGTC_934 2950-0684 338 µM 1.26232267401642 0.163676622969448 no 567 0.103416350518889 140 1121253
SGTC_1964 st076914 61 µM 1.26040403433173 0.164045416644106 no 568 0.10376182352775 155 24208661
SGTC_1003 4049-0218 100 µM 1.25613323669328 0.164868267118184 no 569 0.104533833772118 151 295161
SGTC_1105 epirubicin 18.1 µM 1.25535025224249 0.165019413448174 no 570 0.104675820083526 135 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3196 9111891 49.47 µM 1.25396700155171 0.165286653595807 no 571 0.104926999868798 134 18891510
SGTC_3010 9080089 71.4286 µM 1.25361664658416 0.165354385617472 no 572 0.104990688835107 113 17027233
SGTC_302 1094-0063 18.9 µM 1.25258020870873 0.165554859054992 no 573 0.105179260600149 159 5440289
SGTC_3254 9136651 49.47 µM 1.25249528330161 0.165571292753302 no 574 0.105194722970799 137 16454030
SGTC_1468 k284-1086 134 µM 1.24731381328732 0.166575941385028 no 575 0.106141227245895 147 15996457
SGTC_1356 1502-0781 85.8 µM 1.24539779482585 0.166948437574955 no 576 0.10649278174631 143 567702
SGTC_456 gingerol 170 µM 1.23655361932088 0.168674804677549 no 577 0.10812642391482 135 442793 A herb.
SGTC_2172 5754775 163.918 µM 1.23627958939757 0.168728477446075 no 578 0.108177327622751 166 2263357
SGTC_3293 9120939 62.045 µM 1.23568097273 0.16884576344801 no 579 0.108288586452493 125 934087
SGTC_766 1391-0721 126 µM 1.23553520839827 0.168874330747913 no 580 0.108315690659117 154 1020919 YIL115C NUP159
SGTC_901 1112-0062 60.1 µM 1.23263658888289 0.169443055046559 no 581 0.108855689784947 126 1908457
SGTC_2354 9060492 162 µM 1.23083387515077 0.16979737607795 no 582 0.109192501522991 146 6471895
SGTC_1090 efavirenz 20.7 µM 1.23022215609454 0.169917716549616 no 583 0.109306962619282 135 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1590 st077108 57.8 µM 1.22802211991389 0.170350970638197 no 584 0.109719332221387 122 5489485
SGTC_2806 7952793 58.44 µM 1.22673411114988 0.170604946879123 no 585 0.109961271237183 128 2972490
SGTC_1399 3562-5772 25 µM 1.22607915076532 0.170734188290818 no 586 0.110084445437456 130 23847490
SGTC_1860 st056228 74.6 µM 1.22380448212932 0.171183528565183 no 587 0.110512996550308 158 688679
SGTC_2626 ethyl orsellinate 100 µM 1.22338114264239 0.171267238854118 no 588 0.110592886192679 160 75653 A natural product.
SGTC_3083 9117465 49.47 µM 1.21990221699439 0.171956145544107 no 589 0.111250972653055 131 16420915
SGTC_3116 9124943 49.47 µM 1.21941838911949 0.172052094450348 no 590 0.111342716925308 122 41905195 YPL160W CDC60
SGTC_2143 5623677 140.463 µM 1.21869455795445 0.172195702700324 no 591 0.111480072129565 135 5375313
SGTC_2292 7671323 168.05 µM 1.21719758812273 0.172492944420316 no 592 0.111764523817508 180 937504
SGTC_2391 6285546 200 µM 1.21409931967533 0.173109182414782 no 593 0.11235489989023 127 846083
SGTC_1530 rhein 70.4 µM 1.21344858046522 0.173238790821674 no 594 0.112479181102304 138 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_305 1682-2595 20.8 µM 1.21323163192356 0.173282014419848 no 595 0.112520636767649 143 226033
SGTC_3006 9075424 71.4286 µM 1.20857022300977 0.174212385541639 no 596 0.113414001010387 148 7465181
SGTC_3324 9138759 60.749 µM 1.20826234145211 0.174273947216066 no 597 0.113473184444231 122 45595710
SGTC_868 0527-0199 213 µM 1.20734312222771 0.174457829592999 no 598 0.113650015078158 141 2849450
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.20679457590809 0.174567620544604 no 599 0.113755632738279 126 5379071
SGTC_3193 9111931 49.47 µM 1.20380842852362 0.175166064046887 no 600 0.114331815620851 138 17087244
SGTC_3030 9087619 49.47 µM 1.20267720916034 0.175393107249346 no 601 0.114550628353639 157 25236973
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.20248260437906 0.17543218451505 no 602 0.11458830095179 136 803109
SGTC_1767 st044992 70.3 µM 1.19993250607921 0.175944762379723 no 603 0.115082777130687 130 9600693
SGTC_387 norethindrone acetate 66.7 µM 1.19952830754365 0.176026094557449 no 604 0.115161292243579 139 541197
SGTC_522 1273-0010 11.6 µM 1.19891110270499 0.176150333437324 no 605 0.115281257057603 153 5705015
SGTC_2017 5132927 60.65 µM 1.19607936181605 0.176721053698305 no 606 0.115832795285638 123 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2665 lovastatin 100 µM 1.19605689423064 0.176725586573851 no 607 0.115837178777369 146 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_303 1348-1668 34.2 µM 1.19114731285794 0.177717866057794 no 608 0.116797879424999 139 5380509
SGTC_592 k241-0073 46.5 µM 1.19014037727507 0.177921812199424 no 609 0.116995611315135 150 4230158
SGTC_1231 0242-0792 125 µM 1.18994409403116 0.17796158486581 no 610 0.117034183057458 140 3707635
SGTC_3084 9116877 49.47 µM 1.18600440790614 0.178761064611725 no 611 0.117810279394161 113 27241325
SGTC_3201 9113999 49.47 µM 1.18470402347084 0.179025446939687 no 612 0.118067245554965 134 16649224
SGTC_1688 st021091 57.6 µM 1.1805879327778 0.179863913789235 no 613 0.118883229862979 143 3656366
SGTC_688 0527-0193 473 µM 1.17894590005235 0.180199090637669 no 614 0.119209859441801 161 4007154
SGTC_1716 st033144 30.6155 µM 1.17571590162292 0.180859551175832 no 615 0.119854211041623 151 674617
SGTC_289 k017-0060 526 µM 1.17322601396469 0.181369710274618 no 616 0.120352591331905 148 5512909
SGTC_1981 st071826 47 µM 1.16946268532695 0.182142495915663 no 617 0.12110863339555 148 11838600
SGTC_1289 0976-0073 69.1 µM 1.16849980597932 0.182340549835317 no 618 0.121302608732241 142 3391136
SGTC_414 piperonyl butoxide 100 µM 1.16526172090665 0.183007575719486 no 619 0.121956534391304 152 5794 A potent inhibitor of cytochrome P450.
SGTC_3053 9095903 49.47 µM 1.16251805978742 0.183573943193543 no 620 0.122512546583267 172 17174018
SGTC_72 0744-0168 198.391 µM 1.16248443193439 0.18358089168099 no 621 0.122519372397096 150 677577
SGTC_3309 9129340 25.759 µM 1.16170862366368 0.183741241624455 no 622 0.122676920798483 141 17158987
SGTC_2903 5923464 63.88 µM 1.16105643651437 0.183876108100785 no 623 0.122809474564176 150 2876576
SGTC_40 0327-0103 19.753 µM 1.15715415680002 0.184684352153945 no 624 0.123604691811079 137 409036
SGTC_2832 7992762 51.95 µM 1.15636887114419 0.184847267879496 no 625 0.123765154335043 145 2985177
SGTC_978 1416-0512 87.4 µM 1.15575679824293 0.184974310727382 no 626 0.123890324261812 143 6814003
SGTC_2366 9070441 60.58 µM 1.15515039450636 0.185100230361889 no 627 0.124014422185542 139 6837235
SGTC_695 3505-6186 243 µM 1.15506823643605 0.18511729456628 no 628 0.12403124217083 161 1819379
SGTC_1117 retinoic acid 1.10837 µM 1.15251907912295 0.185647239143843 no 629 0.124553917127033 142 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_774 k060-0086 136 µM 1.15175047701035 0.185807208428002 no 630 0.124711811712252 156 5911235
SGTC_3171 9103192 49.47 µM 1.15161018599725 0.185836416443916 no 631 0.124740646904788 145 13018434
SGTC_221 trifluoperazine 10.304 µM 1.14700624321011 0.186796518117411 no 632 0.125689520324718 184 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1484 3473-2379 286 µM 1.14616076967532 0.186973165415459 no 633 0.125864318403835 134 671917
SGTC_1904 st060225 78 µM 1.1455024312228 0.187110785570737 no 634 0.126000544449817 147 66595
SGTC_955 1216-0110 33 µM 1.14451139430485 0.187318071671423 no 635 0.126205807607361 141 3619719
SGTC_208 k072-0098 12.366 µM 1.14118031159951 0.188015843662343 no 636 0.126897447859354 160 5948901
SGTC_3185 9108267 49.47 µM 1.14077695931877 0.188100443860823 no 637 0.126981375555787 146 4910486
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.13940961289461 0.188387409580947 no 638 0.127266174184194 162 5282362
SGTC_2504 purpurogallin 52.29 µM 1.13888324667988 0.188497950284919 no 639 0.127375927072879 141 5281571 An antioxidant.
SGTC_2349 9023730 187.07 µM 1.13694972372466 0.188904347276732 no 640 0.127779651903033 142 4126287
SGTC_262 fenpropimorph 62.5 µM 1.1331245333403 0.18970993279486 no 641 0.128580980037909 161 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1621 st003705 32.4 µM 1.13207739080775 0.189930828979747 no 642 0.128800949635913 148 24207032
SGTC_2646 retinol 96.75 µM 1.13202295160226 0.189942317328751 no 643 0.128812392625224 168 445354 A vitamin A analog and teratogen.
SGTC_2342 7990637 118.86 µM 1.13146315140858 0.190060477191043 no 644 0.128930102184257 170 2033102 YER133W GLC7
SGTC_49 0717-0965 32.132 µM 1.13136361041493 0.190081492542406 no 645 0.128951040544678 149 5889349 YGL099W LSG1
SGTC_2147 5545932 89.7195 µM 1.12697531671733 0.191009379158791 no 646 0.12987645861183 175 797404
SGTC_1578 josamycin 24.2 µM 1.12622838748923 0.191167590481966 no 647 0.13003443033435 151 5282165 A P450 substrate.
SGTC_959 1222-0044 107 µM 1.12262751996087 0.191931437423631 no 648 0.130797861201716 157 6083612
SGTC_2170 morpholine 200 µM 1.12173605893625 0.192120829900407 no 649 0.130987340013777 143 121171 Reacts with secondary amines.
SGTC_417 st075190 100 µM 1.12002874984205 0.192483869805211 no 650 0.131350755437037 176 222757
SGTC_1752 st044819 83.042 µM 1.11954858602539 0.192586046705474 no 651 0.131453087748097 153 441209 YML126C ERG13
SGTC_253 dyclonine 31.25 µM 1.1159135628667 0.1933606397824 no 652 0.13222956782729 145 3180 An oral anasthetic.
SGTC_1023 4482-3888 16 µM 1.11555078678602 0.193438048524309 no 653 0.132307233868475 175 3303168
SGTC_2755 lomerizine 42.69 µM 1.11392834086021 0.193784475456335 no 654 0.132654964963682 136 3949 A calcium channel blocker.
SGTC_3179 9107801 49.47 µM 1.11181131686558 0.194237073694263 no 655 0.133109642514713 127 4818259
SGTC_443 clozapine 122 µM 1.11136018804026 0.19433360360028 no 656 0.133206670841899 148 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2967 9089538 49.85 µM 1.10835537010376 0.194977301866081 no 657 0.133854185652862 182 728216
SGTC_2064 5220758 200 µM 1.10793976311222 0.195066435989944 no 658 0.133943915731313 175 788518
SGTC_231 b-estradiol 524 µM 1.10140065923306 0.196472118847332 no 659 0.135361159328025 148 450 A steroid.
SGTC_1375 2910-0797 186 µM 1.1006013780233 0.19664435689222 no 660 0.135535092766221 148 742508
SGTC_1479 0549-0158 134 µM 1.09962404583666 0.196855087605714 no 661 0.135747980315093 156 5440202
SGTC_2849 9019321 12.99 µM 1.09956808839786 0.196867157191115 no 662 0.135760176181702 152 16489627
SGTC_2747 doxorubicin 7.63 µM 1.09462199592863 0.197935760282541 no 663 0.136841137520001 102 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2742 clothiapine 36.27 µM 1.09429275260581 0.198007017446265 no 664 0.136913301429762 122 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_276 colchicine 750 µM 1.0931481138708 0.198254868770386 no 665 0.137164386959092 171 2833 A microtubule depolymerizer.
SGTC_2051 5263410 176 µM 1.09268137318763 0.198355986954712 no 666 0.137266860432739 157 227584
SGTC_1016 4226-1401 38 µM 1.09185684055554 0.198534695894082 no 667 0.137448015300895 171 2901613
SGTC_1843 st055809 45.5 µM 1.09067353159984 0.198791335542375 no 668 0.137708280632684 160 16413835
SGTC_179 1273-0063 6.77 µM 1.08991987905275 0.198954894207834 no 669 0.137874219502659 144 3108139
SGTC_2907 7721985 69.9 µM 1.08895864853182 0.199163619358202 no 670 0.138086060668374 141 3267881
SGTC_750 4073-0104 132 µM 1.08789166299029 0.199395462949833 no 671 0.138321468512387 128 22330957
SGTC_2835 9006588 71.43 µM 1.08691239912942 0.199608388569643 no 672 0.138537763035648 133 2345538
SGTC_2862 9027634 71.43 µM 1.08428511183892 0.200180326728493 no 673 0.139119202191609 154 5012562
SGTC_364 0083-0097 67.7 µM 1.08411342838834 0.20021773501044 no 674 0.139157254806938 150 5207356
SGTC_2178 5812956 200 µM 1.0830901752966 0.200440779790287 no 675 0.139384199689244 166 5403383
SGTC_2002 4023503 131 µM 1.08127570817542 0.200836657138264 no 676 0.13978724485803 188 4736863 YCR052W RSC6
SGTC_2944 9067346 25.62 µM 1.08014381430552 0.201083849287843 no 677 0.14003907181718 174 6473075
SGTC_657 3534-0529 86.7 µM 1.07673755748937 0.201828835310487 no 678 0.140798764243073 173 1049549
SGTC_2423 st077119 87.2 µM 1.0765138895889 0.201877811706054 no 679 0.140848746213921 155 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1389 3405-0187 19 µM 1.07575965924797 0.202043017412411 no 680 0.141017379104187 162 799890
SGTC_2200 6600604 21.907 µM 1.07212303972024 0.202840713063219 no 681 0.14183238583199 197 2904777
SGTC_2762 leflunomide 42.06 µM 1.07094068340205 0.203100468689683 no 682 0.142098050752249 195 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_444 curcumin 90.4 µM 1.06994553374616 0.203319250131702 no 683 0.142321912884702 167 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_640 3381-0960 37.1 µM 1.06928346683866 0.203464881945274 no 684 0.142470979084223 179 1745025
SGTC_2438 5259590 200 µM 1.0678894151863 0.203771728458436 no 685 0.142785198849746 169 1201127
SGTC_1522 st012842 45.6 µM 1.06633024060365 0.204115246996645 no 686 0.143137191971517 176 3491067 YOR116C RPO31
SGTC_2643 anethole 100 µM 1.05813388357488 0.205926739901541 no 687 0.144997204344665 182 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2610 ononetin 44.17 µM 1.05728209809503 0.206115540147606 no 688 0.145191430471857 165 259632
SGTC_2375 9072683 200 µM 1.05593521646901 0.206414288980401 no 689 0.145498906719586 180 16798029
SGTC_1342 1486-1464 234 µM 1.0541108358842 0.206819359669741 no 690 0.145916087849761 174 3253938
SGTC_926 2268-1401 59.4 µM 1.05337402314558 0.20698308891151 no 691 0.146084802476646 189 2931578
SGTC_1910 st062352 60.4 µM 1.05218889343025 0.207246600776174 no 692 0.146356447074306 164 2245730
SGTC_1873 rapamycin 2 nM 1.052138158377 0.207257886067971 no 693 0.146368083664743 164 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.0518265011931 0.207327217753046 no 694 0.14643957897597 186 688798
SGTC_1765 st044815 90.4 µM 1.05102321179042 0.20750598182839 no 695 0.146623964610837 188 645695
SGTC_3251 9135047 49.47 µM 1.05026072668674 0.207675749557726 no 696 0.146799128171132 144 17682963
SGTC_1970 st070122 35.8 µM 1.04884038314558 0.207992208536761 no 697 0.14712579387753 196 102928
SGTC_2719 novobiocin 32.65 µM 1.04603468208962 0.208618167415212 no 698 0.147772510055181 172 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1051 3253-3903 78 µM 1.04502928203136 0.208842744661922 no 699 0.148004718100566 196 5509239
SGTC_94 0334-0113 514.748 µM 1.04235272172168 0.209441304622815 no 700 0.148624088713724 187 6795178
SGTC_1874 staurosporine 7.6 µM 1.03870156514957 0.210259439312587 no 701 0.149471776515796 186 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_903 1134-0042 114 µM 1.03702491392952 0.210635763676453 no 702 0.14986212316386 175 701009
SGTC_2146 5545642 200 µM 1.03524266866408 0.211036221607003 no 703 0.150277798325291 168 825326
SGTC_2699 st077704 54.6 µM 1.03434219833558 0.211238720521067 no 704 0.15048810798045 167 645852
SGTC_1154 4088-0362 150 µM 1.03432913126266 0.211241659898824 no 705 0.150491161307651 184 6618304
SGTC_2035 5154463 94.595 µM 1.03307033109948 0.211524933519492 no 706 0.150785493253821 215 2769623
SGTC_1189 1431-2119 7.28 µM 1.03292990003328 0.211556549156009 no 707 0.150818352513534 188 3107275
SGTC_716 1683-5115 658 µM 1.02700040042642 0.212893996600155 no 708 0.152210137765057 183 723597
SGTC_553 k007-0256 45.7 µM 1.02628490589711 0.213055715261561 no 709 0.152378654970208 178 6287000
SGTC_2065 5221596 34.26 µM 1.02251179563186 0.213909711943031 no 710 0.153269366352971 175 788581
SGTC_1348 1493-0373 93.8 µM 1.02034191722569 0.214401738295076 no 711 0.153783165011978 191 3010129
SGTC_1784 st039334 36.3 µM 1.01994605372421 0.214491572450013 no 712 0.153877023110369 199 3496984
SGTC_548 1436-0017 110 µM 1.01899399293719 0.214707715235918 no 713 0.154102909187504 172 9677137
SGTC_2226 7298446 200 µM 1.01699950323055 0.215160926832997 no 714 0.154576832866391 152 3283010
SGTC_2947 9072639 7.68 µM 1.01635788088593 0.215306841841618 no 715 0.154729497498455 188 16488146
SGTC_652 0437-0092 114 µM 1.01414616743223 0.215810260156805 no 716 0.15525650561472 170 3091274
SGTC_2228 7354201 200 µM 1.01321399221857 0.216022641053038 no 717 0.155478979251941 215 753451
SGTC_1196 1588-0294 184 µM 1.01320651947188 0.216024344085347 no 718 0.155480763552656 181 6144269
SGTC_611 3453-1652 23.7 µM 1.01259405956423 0.216163949590938 no 719 0.155627049237069 196 1560575
SGTC_2045 5106652 78.05 µM 1.01086976589335 0.216557269499469 no 720 0.156039383161619 159 673349
SGTC_374 0880-0231 82.3 µM 1.00419120024505 0.218084585388614 no 721 0.157643231413511 200 6833587
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.00293541353894 0.218372462196055 no 722 0.157946012278023 171 4330530
SGTC_25 0118-0223 35.662 µM 1.00144347077931 0.218714759802781 no 723 0.158306228347132 190 5333628
SGTC_1660 st012960 28.1 µM 1.00136978650919 0.218731673241599 no 724 0.15832403270398 176 24207266
SGTC_2990 9074105 71.4286 µM 1.00093729144779 0.218830963047568 no 725 0.158428563128221 183 6502001
SGTC_2702 st077768 96.8 µM 0.99961287072082 0.219135177427582 no 726 0.158748946015587 172 6484119
SGTC_1377 2944-0135 198 µM 0.998938183486574 0.219290243944733 no 727 0.158912318847959 168 1894137
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.997674327654523 0.219580891486469 no 728 0.159218652933099 193 165521
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.996776748972615 0.219787440962783 no 729 0.159436443274615 193 165506
SGTC_1992 st073643 23.3 µM 0.996350004747866 0.219885681817002 no 730 0.159540057746821 187 3161292
SGTC_1043 0916-0009 19.3 µM 0.995730536729957 0.220028334478922 no 731 0.159690544405001 197 3101130
SGTC_1102 cgs 12066b 26.1 µM 0.994939051220797 0.220210676998087 no 732 0.159882954183662 163 6438352 A 5-HT1B full agonist.
SGTC_1329 1447-1697 50.6 µM 0.991734819899503 0.220949753076467 no 733 0.160663450351903 175 2840515
SGTC_412 gemfibrozil 100 µM 0.990579685904805 0.221216539788132 no 734 0.160945430520623 164 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1637 st007924 17.4 µM 0.989401656119459 0.221488804141772 no 735 0.16123333229186 168 683336
SGTC_313 3474-0040 5.03 µM 0.987711864077137 0.221879680428749 no 736 0.161646891204971 198 1043375 YIL048W NEO1
SGTC_125 0133-0007 11.75 µM 0.987025905793105 0.222038466050583 no 737 0.161814969451523 198 26541
SGTC_1440 4100-1550 40 µM 0.986675753118118 0.222119544393425 no 738 0.161900810169334 204 742806
SGTC_2753 fluvastatin 17.09 µM 0.986366255365495 0.222191223099254 no 739 0.161976708937272 188 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2479 5617353 43.85 µM 0.986201035351577 0.22222949293833 no 740 0.162017235667239 188 2731746
SGTC_3295 9122362 53.5725 µM 0.98607614334632 0.222258424114557 no 741 0.162047874744043 205 4730473
SGTC_408 cantharidin 100 µM 0.985487669792128 0.222394772661686 no 742 0.162192292541617 171 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1075 aripiprazole 15.2 µM 0.985423852974573 0.222409561801217 no 743 0.162207958916551 177 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3174 9107204 49.47 µM 0.984099072362225 0.222716697902434 no 744 0.162533401497844 199 3938802
SGTC_889 0919-1524 82.7 µM 0.981653461511467 0.223284320959943 no 745 0.163135299974523 170 3905452
SGTC_3031 9088762 49.47 µM 0.981422126098266 0.223338056196511 no 746 0.163192309701897 184 205253
SGTC_2307 7538926 6.34 µM 0.976873319239435 0.224396159708475 no 747 0.164315936054343 203 96582
SGTC_6 0844-0013 19.835 µM 0.976866008702511 0.224397862508235 no 748 0.164317745899003 218 1584900
SGTC_1630 st005209 31.3 µM 0.976448851058193 0.224495040698593 no 749 0.164421041603564 196 3367314
SGTC_2628 lathosterol 100 µM 0.974665392147873 0.224910772264998 no 750 0.164863132530241 190 6710616
SGTC_3312 9133330 71.43 µM 0.973613775279605 0.225156112845422 no 751 0.165124172003249 202 17617324
SGTC_967 1306-0166 352 µM 0.973328566306104 0.22522267778136 no 752 0.165195014606345 214 4437607
SGTC_1129 3453-1384 223 µM 0.972804135465646 0.225345103806831 no 753 0.165325328481629 193 1084452
SGTC_1662 st014054 52 µM 0.968076794790468 0.226450379596968 no 754 0.166503009049492 188 2838777
SGTC_2407 paclitaxel 400 µM 0.967927463447032 0.226485343814397 no 755 0.166540298670255 192 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.966715445272153 0.22676923667933 no 756 0.166843151878572 186 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1400 3771-8998 51.5 µM 0.9628039111748 0.227686809563459 no 757 0.167822968793378 158 670767
SGTC_2401 5128683 200 µM 0.961612595067481 0.227966684733431 no 758 0.168122121165316 185 708373
SGTC_2694 st077685 81.9 µM 0.960464603149436 0.228236564777329 no 759 0.168410718786857 175 2838096
SGTC_1344 1488-0097 29.1 µM 0.960440071702383 0.228242333805149 no 760 0.168416889305963 211 747966
SGTC_1666 st014829 29 µM 0.959295557749969 0.228511578740105 no 761 0.168704936311873 181 3858230
SGTC_1971 st069429 63.5 µM 0.9590958619911 0.22855857509802 no 762 0.168755227418982 181 1246522 YGL099W LSG1
SGTC_378 3970-0959 8.33 µM 0.958567294711382 0.22868299420912 no 763 0.168888387572874 204 6615653
SGTC_1258 0671-0043 57.1 µM 0.956359786829177 0.229203028951163 no 764 0.16944524694653 206 4298767
SGTC_1018 4259-0013 28.1 µM 0.956034188749923 0.229279787958065 no 765 0.169527480948163 193 6801262
SGTC_1612 st002233 45.4 µM 0.953912566022955 0.229780308472839 no 766 0.170063951079128 189 1035021
SGTC_1142 3253-1408 9.78 µM 0.952846974839985 0.23003192699079 no 767 0.170333804788404 200 256655
SGTC_836 0330-0104 1.35 µM 0.952601973212106 0.230089801126925 no 768 0.170395888543359 180 46494820
SGTC_1872 amphotericin b 148 nM 0.951895780577049 0.230256663099594 no 769 0.170574919826648 191 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1028 k015-0029 4.8 µM 0.951792570300017 0.230281055696778 no 770 0.17060109538875 192 4588309
SGTC_1139 k015-0024 46.9 µM 0.950251325898642 0.230645483482112 no 771 0.170992282310466 204 2766652
SGTC_814 3342-0569 96 µM 0.949220882500676 0.23088931181313 no 772 0.171254141417762 199 4346283
SGTC_2249 haloperidol 116.36 µM 0.946993562635401 0.231416842105576 no 773 0.171821029603313 218 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_715 0868-0130 184 µM 0.946320473783682 0.231576392193939 no 774 0.171992576907384 179 2876258
SGTC_202 3594-0513 34.79 µM 0.946109803424056 0.231626342438282 no 775 0.172046292029071 189 708429
SGTC_440 fluspirilene 35.1 µM 0.945142625470987 0.231855738764461 no 776 0.172293033101837 196 3396 An atypical antipsychotic.
SGTC_1766 st045414 44.774 µM 0.944544350141358 0.231997701687096 no 777 0.17244577475036 199 253960
SGTC_1219 1469-0211 33.1 µM 0.942742111103837 0.232425641828366 no 778 0.172906414028243 218 6822282
SGTC_2427 5545055 42.75 µM 0.942531323440138 0.232475721843112 no 779 0.172960341000723 202 5372858
SGTC_1738 st035555 74 µM 0.941221708898868 0.232787001207291 no 780 0.173295627001903 200 5331140
SGTC_870 0573-2213 57.6 µM 0.937896594872371 0.233578379712237 no 781 0.174148776641068 190 3916321
SGTC_37 0566-0070 1.56 µM 0.936625978865979 0.233881180355446 no 782 0.174475491959195 195 1626686
SGTC_2120 5538279 151.968 µM 0.935511701446739 0.234146902842111 no 783 0.174762327907305 168 2058197
SGTC_2099 5377090 177.372 µM 0.934811240722996 0.23431402771749 no 784 0.174942792802255 203 2243829
SGTC_1729 st035615 45.989 µM 0.93303012782269 0.234739285640199 no 785 0.175402206543206 205 17385451
SGTC_2322 7413319 38.22 µM 0.932407771777404 0.234887979699669 no 786 0.175562914935394 207 1840400
SGTC_2803 7707263 71.43 µM 0.931326594442909 0.235146419616579 no 787 0.175842324614251 171 2199229
SGTC_334 1502-1024 68.5 µM 0.930903192273232 0.235247670601616 no 788 0.175951821540337 184 3296216
SGTC_2351 9026858 72.31 µM 0.929562068237637 0.235568541362401 no 789 0.17629893734572 210 1409300
SGTC_2940 9060638 45.86 µM 0.926155488210507 0.236384667507824 no 790 0.177182590464271 186 4027022
SGTC_2171 5739187 198.077 µM 0.921078017339285 0.237603978366222 no 791 0.178504848136801 189 2262761
SGTC_148 3253-0744 288.01 µM 0.919599498250009 0.237959679704209 no 792 0.178891044513787 205 6893655
SGTC_1242 0402-0103 60.1 µM 0.919222249981998 0.238050484616429 no 793 0.178989667740086 197 432868
SGTC_2304 7443016 91.4 µM 0.916320372988831 0.238749610592171 no 794 0.179749442763019 186 939854
SGTC_2697 mebhydrolin 72.4 µM 0.916026386702697 0.238820500964563 no 795 0.179826527689525 196 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_791 1348-1292 225 µM 0.914498735439874 0.239189056387803 no 796 0.180227421021033 208 5437054
SGTC_2714 st079313 56.9 µM 0.914192162829887 0.239263056374925 no 797 0.180307940754751 177 2939799
SGTC_1944 st076371 56.9 µM 0.912689475034083 0.239625953503467 no 798 0.180702940465987 214 24208455
SGTC_1167 k781-0610 148 µM 0.912315105088239 0.239716410077951 no 799 0.1808014325047 210 4525169
SGTC_557 1315-0110 16.2 µM 0.912229723170475 0.23973704296442 no 800 0.180823900128497 196 6833801
SGTC_2264 7948757 110.76 µM 0.910674422698682 0.240113057172785 no 801 0.181233472264675 184 2971411
SGTC_107 0358-0022 2.6945 µM 0.910359459953953 0.240189242656174 no 802 0.181316485103211 197 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.910169624526442 0.240235167794872 no 803 0.181366530384628 229 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3221 9128209 49.47 µM 0.909184738081799 0.24047350910693 no 804 0.181626309450371 212 16460723
SGTC_662 k832-1615 104 µM 0.908313714444847 0.240684403017413 no 805 0.181856249356566 207 5878478
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.907317058513012 0.240925838701346 no 806 0.182119577955652 214 4620898
SGTC_1103 duloxetine 36.1 µM 0.905630857548432 0.241334613554445 no 807 0.182565635182412 210 60835 A selective serotonin reuptake inhibitor.
SGTC_359 0081-0058 15.9 µM 0.904059359823064 0.24171592064435 no 808 0.182981963228404 207 3494159
SGTC_876 0720-0963 56.8 µM 0.903343684356636 0.241889679941431 no 809 0.183171759273245 199 765861
SGTC_1182 1222-0449 220 µM 0.902987534387677 0.241976175062981 no 810 0.183266255443768 214 658318
SGTC_2115 tiliquinol 12.7705 µM 0.902214997567049 0.242163852174615 no 811 0.183471334718705 209 71208 A bioactive hydroxyquinoline.
SGTC_3133 9127736 49.47 µM 0.901592124331071 0.242315228037451 no 812 0.183636788100094 193 27243420
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.898571428826829 0.243050069522865 no 813 0.184440491403632 176 6708630 An antioxidant.
SGTC_174 3553-0389 74.3 µM 0.89818536760117 0.243144073025018 no 814 0.184543366496836 200 738071
SGTC_3026 9090633 49.47 µM 0.896220956614895 0.243622699217199 no 815 0.185067382594837 211 25236842
SGTC_660 4031-1742 102 µM 0.895565712785021 0.243782461610567 no 816 0.185242377429172 207 6738706
SGTC_2278 7948257 134.34 µM 0.891196595643663 0.244849189603763 no 817 0.186411855229214 207 1247028
SGTC_2276 7947513 42.08 µM 0.889534563997056 0.24525563631091 no 818 0.186857927966403 199 2105100
SGTC_3122 9126309 49.47 µM 0.88950839632123 0.245262038465861 no 819 0.186864956387861 243 17591206
SGTC_3005 9076496 71.4286 µM 0.889154768068027 0.24534856557812 no 820 0.186959954057703 206 21368410
SGTC_421 streptovitacin 30 mM 0.889011389504731 0.245383652667057 no 821 0.1869984793718 204 91467 include heat shock
SGTC_3282 9108498 15.4605 µM 0.888899891946344 0.245410939814373 no 822 0.187028441766756 213 16459645
SGTC_2505 galangin 7.89 µM 0.886379758047574 0.246028134819984 no 823 0.187706461569251 223 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1833 st055984 71 µM 0.886246519016313 0.246060788971438 no 824 0.187742350564862 194 676288
SGTC_1236 0330-0013 258 µM 0.884003323165105 0.246610899126677 no 825 0.188347209463698 206 4617066
SGTC_2263 7948595 193.29 µM 0.883850788091648 0.246648329972219 no 826 0.188388382867381 202 2971371
SGTC_339 3091-4833 71.4 µM 0.883421451494605 0.246753701955515 no 827 0.188504302402632 221 3240077
SGTC_2237 6667747 47.222 µM 0.882618776352805 0.246950766969098 no 828 0.18872114013062 211 729940 YDL015C TSC13
SGTC_2204 7233102 200 µM 0.881403968741612 0.247249174860455 no 829 0.18904960517453 203 2172480
SGTC_99 0109-0120 622.8 µM 0.881094846123391 0.247325139150106 no 830 0.189133243280373 224 759414
SGTC_1856 st057054 55.7 µM 0.879522951934967 0.247711611908413 no 831 0.189558897031644 226 1266018
SGTC_3356 9151811 4.48 µM 0.87684788548484 0.24837005610649 no 832 0.190284632865901 248 1859254 YPR165W RHO1
SGTC_1225 1216-0074 20.6 µM 0.876295737990384 0.248506078441348 no 833 0.190434640712588 216 4241466
SGTC_1952 st077036 64.1 µM 0.876200802669858 0.248529469893516 no 834 0.190460440126479 198 2937007
SGTC_599 1935-0052 86.5 µM 0.875972669047169 0.248585685346718 no 835 0.190522445993108 191 9557311
SGTC_859 0439-0102 54.6 µM 0.872382920282206 0.249471142996623 no 836 0.191499757487809 233 610143
SGTC_2131 toluylene red 5.2905 µM 0.871329010791153 0.249731421221373 no 837 0.191787267273522 183 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2636 apigenin dimethyl ether 100 µM 0.869995913594693 0.250060855346679 no 838 0.192151318693173 216 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_904 1141-0088 396 µM 0.868716914172499 0.250377137448388 no 839 0.192500993819447 203 1378119
SGTC_2883 9059145 45.46 µM 0.867261260931837 0.250737361885734 no 840 0.192899438615179 250 16476510
SGTC_2585 alliin 100 µM 0.86701382454831 0.250798621214411 no 841 0.192967217534347 213 87310 A garlic compound which reacts with lipids.
SGTC_636 0kpi-0074 126 µM 0.865798642416338 0.251099586218295 no 842 0.193300296907083 214 616434
SGTC_1836 st055642 81 µM 0.863336836943868 0.251709888402658 no 843 0.193976148156379 237 8571
SGTC_3301 9125354 19.7965 µM 0.862128213943543 0.252009802610817 no 844 0.194308483563149 191 41905162
SGTC_1804 st050076 49.1 µM 0.861329961635062 0.252207988573449 no 845 0.194528169215827 212 3895976
SGTC_1912 st060209 90.8 µM 0.86074986107177 0.252352064498963 no 846 0.194687912503103 220 688787
SGTC_2589 lobaric acid 100 µM 0.860594453369003 0.252390669499045 no 847 0.194730720939254 210 73157 A novel microtubule depolymerizer.
SGTC_1388 3346-4487 254 µM 0.859558857219346 0.252648002554145 no 848 0.195016131314737 229 3345614
SGTC_2769 toremifene 3.73 µM 0.859079386610523 0.252767191957647 no 849 0.195148359536791 232 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_929 2805-0021 398 µM 0.858869403545952 0.252819400006901 no 850 0.195206285740071 236 3098024
SGTC_3206 9114350 49.47 µM 0.856375895453821 0.253439794148002 no 851 0.195894946624076 207 17087243
SGTC_2125 5246583 200 µM 0.854405799952701 0.253930526455228 no 852 0.196440091709226 231 835267
SGTC_1974 st069448 26.9 µM 0.853736459629639 0.254097366268263 no 853 0.196625513902221 208 6323587 YNR016C ACC1
SGTC_2711 st079103 59.1 µM 0.852996437143725 0.25428189122837 no 854 0.196830639996704 206 54693780
SGTC_593 1203-0218 61.7 µM 0.850925901284924 0.254798553361873 no 855 0.197405257853307 225 3666956
SGTC_2069 5228469 200 µM 0.850873868202103 0.254811544285326 no 856 0.19741971119843 234 2835210
SGTC_1163 k060-0048 49.9 µM 0.850737093658982 0.254845693975471 no 857 0.197457706419214 209 6809982
SGTC_66 0109-0187 42.4 µM 0.850082182318978 0.255009244579162 no 858 0.19763969847805 170 759417
SGTC_3255 9139072 49.47 µM 0.848638734309023 0.255369909759098 no 859 0.198041173303564 218 17646060
SGTC_20 0481-0013 4.944 µM 0.846585648048061 0.255883360274493 no 860 0.198613058140564 233 182045
SGTC_948 3448-0295 75.3 µM 0.845792011299942 0.256081982921584 no 861 0.198834391405571 222 678569
SGTC_2210 7115885 190.385 µM 0.845721419925213 0.256099653645428 no 862 0.198854085468611 223 2927039
SGTC_1004 4084-0029 199 µM 0.84411915729058 0.256500909601591 no 863 0.199301411786106 218 716894 YLR208W SEC13
SGTC_956 1185-0240 191 µM 0.841058582025763 0.257268281313956 no 864 0.200157558301443 219 1416193
SGTC_1923 st058458 19.1 µM 0.837085544906297 0.258266209786648 no 865 0.201272242492437 258 3534982
SGTC_486 niguldipine 82 µM 0.835796058526165 0.258590527523968 no 866 0.201634822116127 225 1236 A calcium channel blocker.
SGTC_2406 ethylparaben 405.7 µM 0.835628872570059 0.258632591774498 no 867 0.201681860338183 198 8434 A possible steroid mimic.
SGTC_3272 9137413 49.47 µM 0.835027370526333 0.258783959934554 no 868 0.201851148922821 230 17614870
SGTC_2493 resveratrol 26.09 µM 0.833438864444314 0.259183928243432 no 869 0.202298631798416 199 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2648 atorvastatin 78.68 µM 0.831701692461923 0.259621694504468 no 870 0.202788672556024 224 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2245 6637752 200 µM 0.828248354660556 0.260493065740132 no 871 0.20376493218399 219 681890
SGTC_2572 astragaloside iv 100 µM 0.828154538131612 0.260516759201845 no 872 0.203791493176806 233 45006101 An anti-inflammatory agent.
SGTC_2219 9098279 200 µM 0.827075789002561 0.260789278127387 no 873 0.204097052962422 199 902349
SGTC_1412 3909-8563 178 µM 0.826138986546671 0.261026056716623 no 874 0.20436262709018 253 23767530
SGTC_82 0054-0107 293.755 µM 0.824709163397259 0.261387660184108 no 875 0.204768364035525 214 3104697
SGTC_520 3584-0023 682 µM 0.824607445593843 0.261413394500194 no 876 0.204797246456896 230 1340790
SGTC_1042 0350-0096 82 µM 0.823997139987459 0.261567827408414 no 877 0.204970591513115 220 3122515
SGTC_818 4072-2707 53.5 µM 0.823387760340766 0.261722072720979 no 878 0.205143760566171 221 882871
SGTC_523 1934-0222 13.7 µM 0.820065112868672 0.262563916718512 no 879 0.206089494546311 240 1361595
SGTC_2409 alverine citrate 63.97 µM 0.820041114653936 0.262570002073548 no 880 0.206096334612126 189 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1933 st074711 15.9 µM 0.81967973296183 0.262661648279408 no 881 0.206199353322553 243 17250958
SGTC_1993 st073995 70.8 µM 0.818147453993737 0.263050415149454 no 882 0.206636497525953 231 3098394
SGTC_1251 0490-5699 265 µM 0.815525245154705 0.263716398486782 no 883 0.207385860044906 241 3883818
SGTC_2918 7977171 22.06 µM 0.812480183679219 0.264490854842798 no 884 0.20825807639046 232 2236483
SGTC_57 miconazole 162.5 nM 0.81113703169388 0.264832828736742 no 885 0.208643490818595 231 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_568 1193-0097 7.48 µM 0.81094023104976 0.264882954137549 no 886 0.208699997613405 226 3646150
SGTC_249 wiskostatin 11.211 µM 0.810490912606392 0.264997414246722 no 887 0.208829042907411 220 2775510 A n-wasp and actin depolymerizer.
SGTC_2642 cholecalciferol 100 µM 0.809339669906452 0.265290798318197 no 888 0.20915989694526 232 9821465 A vitamin D precursor, similar to steriods.
SGTC_2347 9049783 174.81 µM 0.808886210692978 0.265406403656554 no 889 0.209290300631402 258 6467988 YPL169C MEX67
SGTC_215 1287-0124 461.5 µM 0.808132490610802 0.265598614341217 no 890 0.209507157778582 232 5560863
SGTC_603 3794-0023 45.9 µM 0.807224116979867 0.265830357933875 no 891 0.209768686762731 244 3802260
SGTC_1253 0550-0034 176 µM 0.807011947792547 0.265884501136202 no 892 0.209829799830403 220 5969915
SGTC_223 busulfan 5 mM 0.803949086611415 0.266666731131655 no 893 0.21071318974482 231 2478 A DNA alkylator.
SGTC_1148 3909-7663 27.7 µM 0.803520925542613 0.26677617262077 no 894 0.210836853463792 234 4084526
SGTC_2796 7949634 45.45 µM 0.802604224442636 0.267010565258386 no 895 0.211101762940311 250 2971588
SGTC_3067 9117431 49.47 µM 0.800996041241616 0.267422015073404 no 896 0.211566968827634 261 17150885
SGTC_295 k015-0027 31 µM 0.80059036099496 0.26752585787865 no 897 0.211684416379678 230 3887424
SGTC_3086 9117350 49.47 µM 0.800568220646578 0.2675315257741 no 898 0.211690827278795 211 2679265
SGTC_1192 1488-0095 21.4 µM 0.797953348428157 0.268201354638766 no 899 0.212448781487775 241 915875
SGTC_152 4469-0003 551.229 µM 0.796793534516183 0.26849872391315 no 900 0.212785475349168 244 697280
SGTC_1749 st037932 54.2 µM 0.792517332806361 0.269596546399703 no 901 0.214029544675702 248 594497
SGTC_1350 1495-0454 146 µM 0.78986564808416 0.270278437109471 no 902 0.214803117512769 235 1069057
SGTC_533 1222-0222 6.71 µM 0.789184785230667 0.270453662586552 no 903 0.215002006600576 240 3982874
SGTC_505 gw-5074 63.9 µM 0.788589365317976 0.270606945157502 no 904 0.215176024287788 247 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_867 0518-0118 155 µM 0.787459237993495 0.270897999999737 no 905 0.215506540555142 251 6848158
SGTC_3017 9080681 49.47 µM 0.786087112198667 0.271251589375995 no 906 0.215908227047119 242 16451914
SGTC_1815 st051655 58.2 µM 0.784118039692487 0.271759410317672 no 907 0.216485425576626 244 5984156
SGTC_1303 1160-0052 261 µM 0.783828062817603 0.271834234884419 no 908 0.216570502495134 240 3562476
SGTC_15 0266-0086 27.098 µM 0.782483799560205 0.272181237484952 no 909 0.216965151276927 259 1712902 YIL048W NEO1
SGTC_360 0957-0399 1.01 µM 0.781024950834719 0.272558067657268 no 910 0.217393909998525 251 6752301 YPR165W RHO1
SGTC_228 caffeine 993.056 µM 0.778616470491298 0.273180760130751 no 911 0.218102836932649 206 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1739 st037196 92.5 µM 0.776714639534025 0.273672960195957 no 912 0.218663573889171 236 612214
SGTC_1900 st060200 72.8 µM 0.774685106420068 0.274198693442704 no 913 0.219262876883859 234 688945
SGTC_1232 0279-0259 161 µM 0.774618217357919 0.274216028971073 no 914 0.219282644683366 239 1560000
SGTC_1756 st041558 35.5 µM 0.772244797710469 0.274831494359683 no 915 0.219984726754365 264 3955792
SGTC_3128 9127691 49.47 µM 0.770663438293608 0.275241943583877 no 916 0.220453224290698 244 41316314
SGTC_2709 st078560 56 µM 0.77021516425455 0.27535835007523 no 917 0.220586135039942 276 17250903
SGTC_1875 nocodazole 6 µM 0.768307161074411 0.275854085594792 no 918 0.221152360622992 240 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1987 st072290 61.9 µM 0.768257220030794 0.275867067114463 no 919 0.221167192458029 244 54697379
SGTC_1469 k284-2957 126 µM 0.765732063909228 0.276523839315009 no 920 0.221917872213833 230 23884841
SGTC_2784 7567673 72.73 µM 0.765455455571513 0.276595829412583 no 921 0.22200019081719 244 3471247
SGTC_1187 1391-0724 117 µM 0.764022441533707 0.276968932712896 no 922 0.222426934613893 239 6997986
SGTC_2443 5493264 126.67 µM 0.759309975889452 0.278197617238141 no 923 0.223833575671821 257 5340055
SGTC_3080 9117754 49.47 µM 0.758740567784147 0.278346259210599 no 924 0.224003882075446 247 9550191
SGTC_911 3456-4043 236 µM 0.758215845526311 0.278483270363964 no 925 0.224160888379358 255 914281
SGTC_2638 epoxomicin 18 µM 0.755944600185273 0.279076697858503 no 926 0.2248412059546 244 9915668 A protesome inhibitor.
SGTC_1642 st009582 77.7 µM 0.755467935751817 0.279201318030689 no 927 0.224984132128503 273 6739311
SGTC_2320 7373003 200 µM 0.753057057914128 0.279832037150604 no 928 0.225707813798589 243 5415828
SGTC_160 3453-0671 289.699 µM 0.753011777794365 0.279843889667702 no 929 0.225721418278291 271 5322268
SGTC_2220 6782180 200 µM 0.75220684988166 0.280054628102093 no 930 0.225963337479094 230 833803
SGTC_2603 homopterocarpin 100 µM 0.751936329262107 0.280125470458565 no 931 0.226044674717648 256 101795 A weak amylase inhibitor.
SGTC_2372 9071633 200 µM 0.750765660651875 0.280432138367291 no 932 0.226396849505737 242 21321366
SGTC_532 1548-0774 215 µM 0.750095965276474 0.280607644568959 no 933 0.226598454679932 277 5932993
SGTC_1368 1852-0141 284 µM 0.749641760848741 0.280726707573672 no 934 0.226735246086426 249 2838987
SGTC_1877 wortmannin 25 µM 0.749351073330035 0.280802919848091 no 935 0.226822816035936 255 312145 A covalent inhibitor of PI 3-kinase.
SGTC_556 4058-0063 51.5 µM 0.748779348732512 0.280952843432482 no 936 0.226995104384486 247 6615692
SGTC_1623 st003709 20.3 µM 0.747572277369241 0.281269501269839 no 937 0.227359095791517 256 16192618
SGTC_2861 9024595 19.48 µM 0.747016089166775 0.281415467224543 no 938 0.227526924504472 222 16482810
SGTC_350 k064-0020 19.8 µM 0.746943386977624 0.281434549878011 no 939 0.227548867403892 245 2790705
SGTC_2335 9018011 154.17 µM 0.746263863031507 0.281612939478829 no 940 0.227754018229975 236 6458208
SGTC_144 4161-2749 112.381 µM 0.745107100414534 0.281916739824529 no 941 0.228103488522525 262 797501 YMR168C CEP3
SGTC_2095 5432005 200 µM 0.743020439434815 0.282465158165982 no 942 0.228734652936139 266 783734
SGTC_50 0929-0078 56.389 µM 0.742358460703572 0.282639247218537 no 943 0.228935090155311 229 1377751
SGTC_752 1896-0090 130 µM 0.742310347487088 0.282651902179215 no 944 0.228949661955883 253 772567
SGTC_9 0092-0002 10.449 µM 0.740580501999114 0.283107074944827 no 945 0.229473916911186 270 759368
SGTC_3025 9087895 49.47 µM 0.739244546587893 0.283458844304361 no 946 0.229879257689015 264 17173641
SGTC_534 k292-0788 63.4 µM 0.739059276069845 0.283507644274125 no 947 0.229935502045611 281 4146317
SGTC_108 0509-0257 621.132 µM 0.738851906204403 0.283562269952879 no 948 0.229998464448681 248 536624
SGTC_3001 9076041 71.4286 µM 0.735631065544823 0.28441135540525 no 949 0.230977625802721 249 16004211
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.734048582672939 0.284828977778639 no 950 0.231459564521138 267 5355888
SGTC_1208 2323-2347 50.3 µM 0.733646724772092 0.284935075950622 no 951 0.231582037915793 254 5412760
SGTC_735 3076-0345 636 µM 0.733145675158101 0.285067389029965 no 952 0.231734792345141 255 2888990
SGTC_1141 3253-0389 52.6 µM 0.732603692033671 0.285210544466784 no 953 0.231900089315318 270 5402031
SGTC_805 3852-0218 479 µM 0.731942416077391 0.285385255418493 no 954 0.232101857771062 243 6615355
SGTC_3268 9137683 49.47 µM 0.730350938710519 0.285805936990865 no 955 0.232587849551516 310 1953228
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.729940232634254 0.285914548423578 no 956 0.232713359244576 251 1241132 A phosphatase inhibitor.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.727416148783306 0.286582474174012 no 957 0.233485532411257 254 2333 A French combination drug.
SGTC_1096 rimcazole 32.2 µM 0.726588573052694 0.286801629144072 no 958 0.233739015182547 258 18528119 A dopamine reuptake inhibitor.
SGTC_2397 5161689 200 µM 0.725809545939225 0.287008000236067 no 959 0.233977767042231 271 2259942
SGTC_199 4063-0024 41.6 µM 0.725772538213515 0.28701780565584 no 960 0.233989112322728 251 306215
SGTC_2252 omeprazole 400 µM 0.724136925948731 0.287451329359344 no 961 0.234490838355485 243 4594 A proton pump inhibitor.
SGTC_395 anisomycin 6.25 µM 0.723664029273375 0.287576729661856 no 962 0.234636010817798 275 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_470 aa-861 153 µM 0.722679911929184 0.287837775701468 no 963 0.234938279935923 261 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_900 1112-0045 141 µM 0.719536254846304 0.288672408130487 no 964 0.235905286141177 250 56211 YIL048W NEO1
SGTC_2870 9038528 12.99 µM 0.719474876796718 0.288688715174404 no 965 0.235924188176584 261 6463316
SGTC_2024 5144227 134 µM 0.71854837847637 0.288934921798583 no 966 0.236209614753402 243 3475211
SGTC_906 1165-0455 526 µM 0.718502097563265 0.288947223027083 no 967 0.23622387751191 269 3252859
SGTC_2156 5649887 115 µM 0.717210434175229 0.289290639876615 no 968 0.236622131012507 274 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1665 st014639 11.4 µM 0.715874959498924 0.289645906473181 no 969 0.237034280774323 264 981133 YIL048W NEO1
SGTC_290 2043-6722 48.1 µM 0.714705325229885 0.289957223879932 no 970 0.237395573257657 263 773758 YLR208W SEC13
SGTC_2057 5236571 38.335 µM 0.71436544315868 0.290047718497669 no 971 0.237500617305437 251 54684039 YBR257W POP4
SGTC_3350 9150499 3.57 µM 0.713395088894297 0.290306151047861 no 972 0.237800655612369 278 4910996 YPR165W RHO1
SGTC_1826 st055655 41.6 µM 0.712806140884323 0.2904630569883 no 973 0.237982862562129 268 676168
SGTC_3235 9132602 49.47 µM 0.712792552384014 0.290466677668361 no 974 0.237987067434251 265 4912240
SGTC_1191 1487-1166 10.6 µM 0.711138758824738 0.290907491557834 no 975 0.23849912697971 280 3955771
SGTC_2876 9059903 25.97 µM 0.709644185736026 0.291306134440352 no 976 0.238962405896324 251 6916095
SGTC_710 3448-4187 58 µM 0.708796771642196 0.291532275796966 no 977 0.239225300729443 250 3946412
SGTC_2393 9031399 185.94 µM 0.708356565139407 0.291649781829809 no 978 0.239361929146493 281 1526623 YDL150W RPC53
SGTC_1290 0986-0249 10.2 µM 0.70817542153702 0.291698141606676 no 979 0.239418163689228 282 53329
SGTC_3220 9131269 49.47 µM 0.707055962677533 0.291997085614456 no 980 0.239765850513112 278 17722206
SGTC_1203 3992-3522 103 µM 0.707021084793936 0.292006401811104 no 981 0.23977668747459 275 5322312
SGTC_3205 9113483 49.47 µM 0.706881692399838 0.29204363615591 no 982 0.239820000970427 271 17018033
SGTC_361 000s-0510 1.45 µM 0.704383250943618 0.2927113916366 no 983 0.240597066856791 271 660
SGTC_1966 st070145 16.1 µM 0.704053000723409 0.292799710254401 no 984 0.240699883834308 276 3748532
SGTC_838 0109-0203 71.4 µM 0.703509755254734 0.292945016972026 no 985 0.240869064745796 252 759422
SGTC_3157 9099274 49.47 µM 0.702597273805237 0.293189161815225 no 986 0.241153380969662 258 17217662
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.702272240760009 0.29327615090431 no 987 0.241254700685976 256 88881 An O-methylated flavonoid and antioxidant.
SGTC_997 3996-0078 137 µM 0.701547690770009 0.29347010636623 no 988 0.24148064157552 257 735687
SGTC_1448 4255-0083 152 µM 0.699538081509273 0.294008371225309 no 989 0.242107911404905 287 5399660
SGTC_1884 5633444 25 µM 0.697256257004371 0.294620100475347 no 990 0.242821218956481 274 5724239
SGTC_455 paf C-16 10 µM 0.697234117918598 0.294626038568618 no 991 0.242828145290519 257 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2492 derrusnin 100 µM 0.696864487800989 0.294725188040166 no 992 0.242943801886616 283 1715307 Part of coumarin class of compounds.
SGTC_1127 asiatic acid 681.4 nM 0.695449912664389 0.295104775292909 no 993 0.243386695020546 279 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1274 0865-0114 173 µM 0.694640694971456 0.295322022047875 no 994 0.243640251205479 258 870624
SGTC_1491 4138-0063 26.5 µM 0.694419251607541 0.295381484698107 no 995 0.243709661999387 264 23883227
SGTC_3176 9106582 49.47 µM 0.693902778712015 0.295520190982372 no 996 0.243871590440082 239 17018027
SGTC_2026 5148700 152 µM 0.691433717500156 0.296183706643608 no 997 0.244646510569241 270 79838
SGTC_3225 9130819 49.47 µM 0.689212201221147 0.296781282503216 no 998 0.245344869861255 294 4547121
SGTC_2746 daunorubicin 9.88 µM 0.685611839604434 0.297750930542923 no 999 0.246478956755295 242 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.685257806858012 0.297846356502321 no 1000 0.246590625899347 232 4000243
SGTC_3118 9124250 49.47 µM 0.684593707304277 0.298025395452083 no 1001 0.24680016950919 268 1504786
SGTC_2707 st078556 66.6 µM 0.68310692846058 0.298426403610556 no 1002 0.247269638851551 266 17250899
SGTC_2935 9038016 29.96 µM 0.682557160644247 0.298574746989221 no 1003 0.247443355879027 274 6463195
SGTC_1701 st028638 40.4 µM 0.681674110003933 0.298813089958411 no 1004 0.247722520913599 274 3490878
SGTC_2251 lansoprazole 556 µM 0.680336223382116 0.299174361706669 no 1005 0.248145796684932 276 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_880 0833-0487 87.2 µM 0.679112497039126 0.29950498003587 no 1006 0.248533292361847 283 76075
SGTC_2748 diazoxide 86.69 µM 0.678691272036467 0.299618822137886 no 1007 0.248666748746459 225 3019 A potassium channel activatior.
SGTC_944 3370-0224 231 µM 0.677140790629223 0.300038030792547 no 1008 0.249158315175854 257 4580514
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.676139237535399 0.300308964914246 no 1009 0.249476123281036 273 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1135 dihydrocapsaicin 536.708 nM 0.674425868400172 0.30077271141657 no 1010 0.250020300575496 293 107982 A Capsaicinoid.
SGTC_3305 9127027 53.8275 µM 0.672248361320695 0.301362548908371 no 1011 0.25071279894503 282 41905295
SGTC_961 1252-1571 372 µM 0.672071979154484 0.301410349645712 no 1012 0.250768937052459 293 6813498
SGTC_745 0469-0705 296 µM 0.670303851106456 0.301889712535582 no 1013 0.251332056322171 301 3486736
SGTC_2362 9071156 126 µM 0.669546723132965 0.302095084636516 no 1014 0.2515733932025 292 653133
SGTC_2298 7976326 193.81 µM 0.668116096502534 0.302483315403435 no 1015 0.252029743870456 258 2235818
SGTC_891 0929-0073 133 µM 0.662491684563186 0.304011781967779 no 1016 0.253828081137149 295 5603632
SGTC_2433 5607874 27.82 µM 0.661780115734827 0.304205400039489 no 1017 0.254056075665372 284 2252428
SGTC_913 3487-1245 167 µM 0.661604321183492 0.304253242245215 no 1018 0.254112418730287 271 4016153
SGTC_1112 tnp00069 1.16933 µM 0.659317770475888 0.304875828362711 no 1019 0.254845866704734 277 145826
SGTC_2152 5568786 200 µM 0.65823769788936 0.305170109177372 no 1020 0.255192702312677 290 5399883
SGTC_2851 9015922 71.43 µM 0.658039827921216 0.305224035267027 no 1021 0.255256269552382 289 2996893
SGTC_1365 1672-3266 55.4 µM 0.657819174940228 0.305284175465336 no 1022 0.255327165770913 287 6415873
SGTC_379 3970-0972 5.9 µM 0.656022579794471 0.305774043005535 no 1023 0.255904798030827 287 2898042 YBL034C STU1
SGTC_113 0099-0221 2.5 µM 0.655765174197597 0.305844256849101 no 1024 0.255987613603137 282 89219
SGTC_139 0099-0334 718.624 µM 0.65568983866221 0.305864807859274 no 1025 0.256011854087095 300 97690
SGTC_1526 st051518 75 µM 0.655664151608063 0.305871815248771 no 1026 0.256020119605409 285 673993
SGTC_3061 glucosamine 200 µM 0.654816181267527 0.306103180157635 no 1027 0.256293055587878 269 91431 and experimental redox chemotherapeutic
SGTC_3163 9099914 49.47 µM 0.653884415075254 0.306357497603476 no 1028 0.256593137718613 311 16268368
SGTC_3120 9124077 49.47 µM 0.652845591842703 0.306641145346448 no 1029 0.256927913959662 303 18774327 YGL155W CDC43
SGTC_1333 1482-0047 286 µM 0.651206668690691 0.307088884197772 no 1030 0.257456543061763 289 3811116
SGTC_1194 1488-0194 225 µM 0.651026105604685 0.30713822999744 no 1031 0.257514817608965 294 1391452
SGTC_910 3454-3003 490 µM 0.649905847755545 0.30744446152292 no 1032 0.257876520308885 296 820824
SGTC_1631 benzylvanillin 81.9 µM 0.643957647057219 0.30907269531368 no 1033 0.259801449218239 271 75506
SGTC_1700 st030840 7.9285 µM 0.64389423563022 0.309090073572962 no 1034 0.2598220099954 295 5499307
SGTC_1616 st002734 56.1 µM 0.638785201495195 0.310491634319475 no 1035 0.261481338293734 288 4026101
SGTC_2189 6047310 154.431 µM 0.638410367003645 0.31059457136991 no 1036 0.261603292116478 285 711535
SGTC_2745 rifampicin 24.3 µM 0.636701194928124 0.311064132122517 no 1037 0.262159747544173 267 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2647 atorvastatin 60.16 µM 0.635526649505825 0.311386993373406 no 1038 0.262542495788924 280 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_989 1501-0895 10.3 µM 0.63476290033314 0.311597012061212 no 1039 0.262791531533082 295 2830112
SGTC_724 3910-0327 137 µM 0.633699893797497 0.311889423727778 no 1040 0.263138347135222 316 2885483
SGTC_1190 1486-1332 13 µM 0.631427761016963 0.312514839181476 no 1041 0.263880434560579 297 4150046
SGTC_2962 9082311 13.18 µM 0.631065440001056 0.312614619779608 no 1042 0.263998868570992 302 16459453
SGTC_2318 6029776 164 µM 0.63079884277451 0.312688047508087 no 1043 0.264086030076786 311 818325
SGTC_606 k015-0008 38.6 µM 0.627461375773998 0.313607900027263 no 1044 0.265178423374667 306 1970475
SGTC_2540 epiandrosterone 100 µM 0.627331083324157 0.313643834012131 no 1045 0.265221116161953 308 441302 A steroid.
SGTC_1176 0848-0131 83.3 µM 0.626988162564221 0.313738418237662 no 1046 0.265333497317416 300 6769040
SGTC_848 0368-0089 85.6 µM 0.625623086464348 0.314115054144713 no 1047 0.265781096212924 298 762535
SGTC_2198 6589944 200 µM 0.624527137584722 0.314417575794126 no 1048 0.266140726963495 275 5290268
SGTC_2489 cantharidin 73.42 µM 0.622583209702963 0.314954477008001 no 1049 0.266779223805657 294 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2148 5546263 113.568 µM 0.621815977823005 0.315166489602208 no 1050 0.267031439426739 293 792097
SGTC_246 cycloheximide 667 µM 0.621494109300315 0.315255451097618 no 1051 0.267137284570189 291 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2545 solidagenone 89.61 µM 0.621486346258677 0.315257596863166 no 1052 0.267139837676136 258 6708572 An anti ulcer agent
SGTC_1349 flufenamic acid 69 µM 0.621351387209626 0.315294901597913 no 1053 0.267184224921181 296 3371 A non-steroidal anti-inflammatory.
SGTC_1850 st056238 17 µM 0.620494740020628 0.315531735818286 no 1054 0.267466057971345 308 5393177
SGTC_2765 myclobutanil 7.74 µM 0.620199371933565 0.31561341276591 no 1055 0.267563267482778 324 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1072 oxiconazole 14.9 nM 0.620197714650604 0.315613871073109 no 1056 0.267563812966585 277 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3299 9121982 43.1275 µM 0.61903188488164 0.315936341393733 no 1057 0.26794767705072 296 17594604 YPL160W CDC60
SGTC_2717 st081029 62.2815 µM 0.618715008085808 0.316024014234537 no 1058 0.268052060625616 312 5292846
SGTC_1478 0453-0656 35.7 µM 0.618621791860766 0.316049807084017 no 1059 0.268082771228537 309 5258496
SGTC_3191 9110352 49.47 µM 0.618241365242101 0.316155080085486 no 1060 0.268208123250884 310 17122424
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.616214154267094 0.316716308264553 no 1061 0.268876593927091 304 1273210
SGTC_1009 4106-0057 9.87 µM 0.613147406574845 0.317566131623728 no 1062 0.269889438325257 291 2928005
SGTC_2969 9091408 28.7 µM 0.612428474180318 0.31776549365372 no 1063 0.270127153746606 303 4286311
SGTC_3079 9117512 49.47 µM 0.607045620606204 0.319259850250234 no 1064 0.271910318456438 350 7185044
SGTC_3334 9142812 21.919 µM 0.606260926814161 0.319477938583165 no 1065 0.272170750230001 305 45283678
SGTC_1842 st055362 61.2 µM 0.605834854646332 0.319596382113429 no 1066 0.272312211105279 288 676032
SGTC_1555 citronellol 128 µM 0.605528968392223 0.319681426588143 no 1067 0.272413791392166 303 8842 A terpine precursor.
SGTC_778 3456-2434 196 µM 0.605528768785734 0.319681482087126 no 1068 0.272413857684663 277 5539063
SGTC_2905 7799065 20.05 µM 0.604150149452718 0.320064892395115 no 1069 0.272871910193168 301 1296806
SGTC_2469 5655019 90.81 µM 0.603574506007052 0.320225042551448 no 1070 0.273063283317645 309 2788239
SGTC_2602 kawain 100 µM 0.60023358599393 0.32115518273336 no 1071 0.27417528660492 295 5369129
SGTC_1768 st044301 37.178 µM 0.599319602323724 0.321409839364771 no 1072 0.274479889263358 329 3931349
SGTC_2857 9024691 58.44 µM 0.596602138592363 0.32216748214651 no 1073 0.275386521540611 330 16478292
SGTC_2926 9010726 65.15 µM 0.59619764009212 0.322280321704771 no 1074 0.275521600984311 297 2994293
SGTC_3059 1327-0034 3 µM 0.595569108342944 0.32245569043838 no 1075 0.275731559402165 302 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2978 9011784 42.97 µM 0.594222226922023 0.322831621325762 no 1076 0.276181744186723 304 2994934
SGTC_2129 girgensonine 121.053 µM 0.594135684981851 0.32285578242394 no 1077 0.276210682496198 308 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2731 amoxapine 43.43 µM 0.593003322643707 0.323171988385087 no 1078 0.276589464309385 329 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1594 piperine 70.1 µM 0.592886335752028 0.323204663619809 no 1079 0.276628611614013 301 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_431 k089-0097 107 µM 0.589810474184402 0.324064261439122 no 1080 0.277658859860306 300 5499420
SGTC_1710 st031758 61.5 µM 0.589659459656511 0.324106489036337 no 1081 0.277709489837926 309 5394341
SGTC_2176 5809774 33.9695 µM 0.5881352712379 0.324532818448845 no 1082 0.27822075006587 295 2870539
SGTC_2934 9036370 36.88 µM 0.587769827526367 0.324635070601734 no 1083 0.278343399434911 307 6462800
SGTC_333 3486-0131 40.1 µM 0.586978625017662 0.324856496516707 no 1084 0.278609031240377 301 6744690
SGTC_2941 9056145 11.23 µM 0.586753767981282 0.324919436299411 no 1085 0.278684545409225 304 2119517
SGTC_671 0560-0003 407 µM 0.584844842623438 0.325453965175392 no 1086 0.279326024556189 295 3238678
SGTC_2840 9008771 71.43 µM 0.583725585197876 0.325767541847744 no 1087 0.27970247543032 269 2992978
SGTC_175 3793-3120 23.7 µM 0.583468177286431 0.325839675964227 no 1088 0.279789086777411 333 5322297
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.583043057763154 0.325958822635175 no 1089 0.279932157384571 320 6708784 An antioxidant flavonoid
SGTC_3281 9140613 49.47 µM 0.582349810473527 0.326153154599402 no 1090 0.280165540333312 280 16013766
SGTC_1247 0448-0043 5.84 µM 0.58226682709749 0.326176419770498 no 1091 0.280193483153235 328 3089013 YGL099W LSG1
SGTC_1331 1472-0049 76.2 µM 0.580790504080521 0.326590433838994 no 1092 0.28069082789928 317 24051409
SGTC_1503 4585-0012 61.3 µM 0.579922802360688 0.326833868339013 no 1093 0.280983338976964 309 2922052
SGTC_1867 st057372 64 µM 0.578782481499091 0.327153898483355 no 1094 0.281367976598498 299 688837
SGTC_1744 st037937 38.9 µM 0.578500513089774 0.327233052305991 no 1095 0.281463125544301 312 1016152
SGTC_426 0988-0037 14.6 µM 0.575802276179304 0.327990890530372 no 1096 0.282374417424107 313 5383008
SGTC_323 4013-0906 34.3 µM 0.573757416014069 0.328565690907134 no 1097 0.283065984468672 285 2910086
SGTC_1861 st057647 17.4 µM 0.572997867532897 0.328779299800727 no 1098 0.283323068922139 321 688668
SGTC_2119 5528445 120.635 µM 0.572983573253863 0.328783320337601 no 1099 0.283327908181448 310 791935
SGTC_3144 9087057 49.47 µM 0.571575353293599 0.329179505960149 no 1100 0.283804848452668 331 17249618
SGTC_1330 1469-0054 61.8 µM 0.569510941001041 0.329760650164081 no 1101 0.284504723955722 328 7102664
SGTC_1606 st000094 49.2 µM 0.569464547684004 0.329773714885388 no 1102 0.284520461649946 299 1242210
SGTC_572 0960-0087 17.7 µM 0.567889093956938 0.330217498181739 no 1103 0.285055138916079 330 6796365
SGTC_2955 9076254 12.21 µM 0.563713279466327 0.331394921471448 no 1104 0.286474639216026 293 16459619
SGTC_1515 3460-0031 42.1 µM 0.561948962885169 0.331892894753167 no 1105 0.287075396278679 308 2876596
SGTC_2989 9073649 71.4286 µM 0.561233418929313 0.332094939714634 no 1106 0.287319211866082 348 21367202
SGTC_2794 7785382 27.27 µM 0.561035405438412 0.332150860529975 no 1107 0.287386700602471 334 2205081
SGTC_2617 dihydrotanshinone i 20.83 µM 0.560125791658605 0.332407791763635 no 1108 0.287696819644727 300 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.554345342833225 0.334042384844124 no 1109 0.289671262182756 296 6708739 YPR165W RHO1
SGTC_740 k014-0057 261 µM 0.553748738759405 0.33421127235158 no 1110 0.289875407299035 340 4012779
SGTC_1254 0550-0035 264 µM 0.553706169601325 0.334223324171316 no 1111 0.289889976130599 327 15121435
SGTC_968 1309-0633 340 µM 0.553338414643359 0.334327446957071 no 1112 0.290015850562802 322 3761976
SGTC_3004 9076122 71.4286 µM 0.549979734992648 0.335278981898396 no 1113 0.291166636586819 347 44782551
SGTC_935 2996-0153 430 µM 0.549967927507974 0.335282328902018 no 1114 0.291170685949412 329 23738523
SGTC_1056 3448-1962 115 µM 0.54966773749168 0.335367426528756 no 1115 0.291273644583988 325 715507
SGTC_1618 st003135 44.5 µM 0.548940593220636 0.335573591815389 no 1116 0.291523109633514 335 1270615
SGTC_2892 9047358 58.44 µM 0.546197586810313 0.336351754381178 no 1117 0.292465062390058 336 6466771
SGTC_973 1325-0077 65.9 µM 0.535914483827909 0.339275186480938 no 1118 0.296008826942558 333 2835149
SGTC_287 k060-0039 29.6 µM 0.535809253812335 0.339305153260487 no 1119 0.296045193008082 317 5861974
SGTC_1950 st077106 7.18 µM 0.534172596080488 0.339771361668063 no 1120 0.296611063486439 307 13831864
SGTC_2153 5569715 200 µM 0.534021057908855 0.339814540327414 no 1121 0.296663482496188 340 2054701
SGTC_1908 st060353 56.5 µM 0.533851267344851 0.339862922244702 no 1122 0.296722220283398 341 4227716
SGTC_1997 st073024 93.8 µM 0.533138632738429 0.340066016641958 no 1123 0.296968809000636 321 686268
SGTC_2779 methotrexate 400 µM 0.528741791656533 0.341320101182628 no 1124 0.298492290964944 338 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_131 0141-0277 33.849 µM 0.527902026716551 0.341559822245294 no 1125 0.298783668980025 346 1547771
SGTC_1731 st035964 63 µM 0.527821421022777 0.341582835479755 no 1126 0.298811643994069 342 6739575
SGTC_945 3381-0768 11.3 µM 0.526839489824041 0.341863227860823 no 1127 0.299152528584903 336 1126236 YIL048W NEO1
SGTC_207 4185-0010 4.486 µM 0.526557169494739 0.341943861141337 no 1128 0.299250570809091 331 3761753
SGTC_980 1473-0395 201 µM 0.525893178965369 0.342133531351588 no 1129 0.299481214227101 337 768876
SGTC_794 k038-0031 316 µM 0.525693305717074 0.34219063334391 no 1130 0.299550657875262 325 6624242
SGTC_1029 k015-0030 64.7 µM 0.524328083702577 0.342580761461424 no 1131 0.300025183508486 322 2208316
SGTC_2656 pseudo-anisatin 100 µM 0.522107482876874 0.343215682747585 no 1132 0.300797748374088 356 6708809 A neurotoxin.
SGTC_1802 st050112 57.9 µM 0.522048134471229 0.343232657916905 no 1133 0.30081840846997 330 4662563
SGTC_2727 riluzole 51.77 µM 0.521200758569354 0.34347506368884 no 1134 0.301113462889845 340 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3253 9135987 49.47 µM 0.520748804207502 0.343604378983243 no 1135 0.301270885709552 318 4182430
SGTC_700 3453-2283 142 µM 0.520659840342129 0.343629835896914 no 1136 0.301301877590063 318 565664
SGTC_2382 9035899 200 µM 0.520401603594913 0.343703734078873 no 1137 0.301391846317547 336 6462679
SGTC_2486 5283202 22.39 µM 0.518969984090004 0.344113520988468 no 1138 0.301890836462344 328 1377751
SGTC_3223 9129970 49.47 µM 0.517646767667703 0.344492441465486 no 1139 0.302352372603126 333 17248386
SGTC_1689 st020265 53.493 µM 0.517631030514022 0.344496948947123 no 1140 0.302357863605634 350 5758320 YPR016C TIF6
SGTC_638 3970-0837 4.09 µM 0.516198530201855 0.344907342299519 no 1141 0.302857878369425 320 4118451 YLR208W SEC13
SGTC_2053 5265679 138 µM 0.512785626186818 0.345885831172006 no 1142 0.304050642731945 340 764595
SGTC_288 1315-0019 35.1 µM 0.512639627269253 0.345927712481432 no 1143 0.30410171407584 341 6811474
SGTC_2196 6573537 42.6665 µM 0.51143531518755 0.346273253804408 no 1144 0.304523135791656 347 2903087
SGTC_3315 9136395 68.55 µM 0.51012385653094 0.346649683221221 no 1145 0.304982346330979 375 16876844
SGTC_886 0866-0150 153 µM 0.509830260500279 0.346733975173951 no 1146 0.305085191839107 346 271463
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.509427076685872 0.346849742341648 no 1147 0.305226450593339 345 689007
SGTC_1790 st045711 43.5 µM 0.508228898884729 0.347193862455162 no 1148 0.30564641318697 310 585119
SGTC_211 3455-0679 143.504 µM 0.507713889247712 0.347341813448574 no 1149 0.30582700324741 311 748649
SGTC_2199 6590217 200 µM 0.506888344498844 0.347579022908073 no 1150 0.306116582120034 332 703109
SGTC_336 4111-0029 111 µM 0.506752824373579 0.347617968545538 no 1151 0.306164130516678 350 3131175
SGTC_2121 5257820 149.641 µM 0.505785980893798 0.34789586569938 no 1152 0.30650345054707 321 791256
SGTC_684 1140-0066 328 µM 0.504349985902503 0.348308760574005 no 1153 0.307007728611218 330 6813534
SGTC_3074 9116018 49.47 µM 0.503819308771228 0.348461392901361 no 1154 0.307194178887697 359 17027303
SGTC_2033 5192550 145 µM 0.503716033741773 0.34849109951831 no 1155 0.307230469756143 307 182073
SGTC_2761 levamisole 97.89 µM 0.503509617536391 0.348550477034372 no 1156 0.307303010114311 349 26879 An alkaline phosphatase inhibitor.
SGTC_1089 terbinafine 2.25 µM 0.502932303437991 0.348716566432634 no 1157 0.30750593426594 350 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2256 7954252 200 µM 0.502065047576533 0.348966124627197 no 1158 0.307810882802087 354 2972920
SGTC_1200 1643-0193 18.4 µM 0.500405996552937 0.349443708724499 no 1159 0.30839461592787 357 5403974
SGTC_627 1391-0720 175 µM 0.496436051881029 0.350587486862681 no 1160 0.309793397248983 387 997839
SGTC_519 k048-0011 62.8 µM 0.494802850982392 0.351058421527673 no 1161 0.310369645853309 329 6836379
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.492778573511764 0.351642440963247 no 1162 0.311084525938194 345 15053
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.49049593794497 0.352301418891536 no 1163 0.311891501763248 363 61125 An anti-inflammatory.
SGTC_416 estradiol valerate 100 µM 0.489256575945939 0.352659398381128 no 1164 0.312330029934297 349 13791 A steroid.
SGTC_1094 duloxetine 25.4 µM 0.488698634846647 0.352820597687467 no 1165 0.312527535212215 314 60834 A selective serotonin reuptake inhibitor.
SGTC_3297 9117502 71.43 µM 0.487895653240642 0.353052640019068 no 1166 0.312811876775458 310 7453720
SGTC_141 0443-0274 32.331 µM 0.486285118952976 0.353518210286526 no 1167 0.313382514254888 314 1627241
SGTC_2998 9066762 71.4286 µM 0.486248745321467 0.353528727642663 no 1168 0.313395407168205 369 4945196
SGTC_2371 9071574 200 µM 0.486139025951418 0.35356045343635 no 1169 0.313434299423721 347 45596039
SGTC_787 4152-0075 138 µM 0.485503104786308 0.353744352607696 no 1170 0.313659755420028 332 9566539
SGTC_780 0109-0199 192 µM 0.483992473201763 0.354181342122686 no 1171 0.314195605432726 365 610414
SGTC_3039 9090270 49.47 µM 0.483452475743849 0.354337597082595 no 1172 0.314387248031631 318 17173750
SGTC_3130 9127414 49.47 µM 0.482969226224469 0.354477452117065 no 1173 0.314558793477092 327 1494646
SGTC_665 3914-0008 307 µM 0.482763898635392 0.354536880977229 no 1174 0.314631693438242 343 1069549
SGTC_1355 1499-0035 1.68 µM 0.481024596643896 0.355040436665888 no 1175 0.315249508706734 357 1548538
SGTC_1562 morin hydrate 59.1 µM 0.479574985638264 0.355460315765604 no 1176 0.315764818356777 342 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1504 k297-0033 30 µM 0.479165343856836 0.355579000126101 no 1177 0.3159105033424 316 4388117
SGTC_2778 tioconazole 65.09 nM 0.478172128005206 0.355866819879534 no 1178 0.316263849279697 344 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.477762754406439 0.355985474419938 no 1179 0.316409536676362 341 6708514
SGTC_1895 st058434 18.3 µM 0.476133026816338 0.356457979630926 no 1180 0.316989804576287 372 5393175
SGTC_924 2046-0044 21.3 µM 0.474608828683475 0.356900088297803 no 1181 0.31753290615323 330 3623589
SGTC_530 4358-1714 28 µM 0.474464594092911 0.356941934926899 no 1182 0.317584320126862 342 1564641
SGTC_1164 k060-0068 93.7 µM 0.474393338303562 0.356962608928922 no 1183 0.317609721319178 336 5963676
SGTC_1866 st057638 64 µM 0.474198518275594 0.357019135738444 no 1184 0.317679174950221 339 688802
SGTC_1151 3909-8316 15.3 µM 0.471280492363402 0.357866172615482 no 1185 0.318720222225085 362 800431
SGTC_1721 st082152 9.2685 µM 0.47015226354667 0.358193859869562 no 1186 0.319123118334005 349 5296051
SGTC_3238 9133470 49.47 µM 0.469850009955067 0.358281665356655 no 1187 0.319231090913559 343 3534688
SGTC_1841 st054148 70 µM 0.469804596055561 0.358294858865237 no 1188 0.319247315225172 369 675442
SGTC_998 3996-0085 177 µM 0.469706064213088 0.358323484619507 no 1189 0.319282517341409 347 715391
SGTC_1123 mangostin 811.285 nM 0.469308536570482 0.358438983578907 no 1190 0.319424557153042 324 5281650 An antioxidant.
SGTC_2341 7987486 176.74 µM 0.469219150202664 0.358464955965468 no 1191 0.319456499268553 356 1258686
SGTC_120 rhodamine 6G 52.259 µM 0.46903701166091 0.35851788074403 no 1192 0.319521590412578 368 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1953 st076800 12.1 µM 0.46782560823263 0.358869952540573 no 1193 0.319954653015719 337 297591
SGTC_1967 st070177 51.4 µM 0.467125121644055 0.359073590639672 no 1194 0.320205180858331 369 5729214
SGTC_1008 4106-0037 6 µM 0.465557900813758 0.35952934157395 no 1195 0.320765991517218 360 2905394
SGTC_1892 st058411 7.36 µM 0.464745138420634 0.359765773243698 no 1196 0.321056989776288 343 3934738
SGTC_2512 diallyl trisulfide 49.23 µM 0.462318187409925 0.360472089702575 no 1197 0.321926579478057 377 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2173 5763948 167 µM 0.461962073477049 0.360575769808581 no 1198 0.322054259260321 346 2867177
SGTC_291 SEC14.278 35.5 µM 0.460639703144668 0.360960858426203 no 1199 0.322528560793903 348 1068044
SGTC_1928 4'-methoxychalcone 40.3 µM 0.459748792493826 0.361220380808064 no 1200 0.322848271393606 388 641818
SGTC_1309 pyrazolanthrone 13.4 µM 0.458896028694571 0.361468850851415 no 1201 0.32315441537162 382 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1014 4130-3005 69.3 µM 0.458531113280868 0.361575194224106 no 1202 0.32328545738384 362 743608
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.458197490756295 0.361672427604246 no 1203 0.323405281232245 354 229346 A bile salt which induces apoptosis.
SGTC_619 1652-1634 108 µM 0.457560995460107 0.361857957204319 no 1204 0.323633935652222 352 5400454
SGTC_81 0411-0046 9.971 µM 0.456952740267983 0.362035285547244 no 1205 0.323852507339901 341 12925265
SGTC_587 k089-0003 57 µM 0.456482244691753 0.362172472308646 no 1206 0.324021617879612 360 9659696
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.455862682885993 0.362353150701247 no 1207 0.324244362799339 380 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_86 0417-1630 471.922 µM 0.455782190738764 0.362376626303991 no 1208 0.324273305963469 351 3634867
SGTC_2415 st077333 57.7 µM 0.455613569370952 0.362425806545968 no 1209 0.324333941853419 399 2766255
SGTC_2275 7947463 200 µM 0.455257621131834 0.362529630146046 no 1210 0.324461955387898 349 1225414
SGTC_1625 st003711 30.1 µM 0.452360627080689 0.36337500577723 no 1211 0.325504603244899 348 24207034 YER133W GLC7
SGTC_59 0330-0160 1.33 µM 0.450749683730871 0.363845385626329 no 1212 0.326084984700526 355 4293482
SGTC_1805 st050013 60.3 µM 0.448566697744338 0.364483123812872 no 1213 0.326872130901624 357 4037144
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.448101929097219 0.364618949981491 no 1214 0.32703981794079 380 6708760
SGTC_3051 9093778 49.47 µM 0.447179437640587 0.364888593544497 no 1215 0.327372753335909 393 17217378
SGTC_2945 9067681 61.76 µM 0.442256606295699 0.366328660544747 no 1216 0.329151764063503 391 16456930
SGTC_2818 7996756 12.99 µM 0.442065368753267 0.366384641071888 no 1217 0.329220951869218 379 2241621
SGTC_1508 1080-0625 72.9 µM 0.440364874833698 0.366882547678628 no 1218 0.329836430364675 354 767111
SGTC_1929 genistein trimethyl ether 50.5 µM 0.43976387685964 0.367058574211743 no 1219 0.330054066527536 361 136420
SGTC_474 dl-dihydrosphingosine 5 µM 0.438963298168007 0.367293099429717 no 1220 0.330344065127406 328 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_908 3448-7491 47.7 µM 0.437992122463517 0.367577666586165 no 1221 0.330695996955922 324 1203031
SGTC_2608 thymoquinone 42.66 µM 0.436572642047975 0.367993723665044 no 1222 0.331210653429794 356 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3072 9116419 49.47 µM 0.43593264975783 0.368181359423032 no 1223 0.331442797784581 345 17170162
SGTC_1693 xanthone 101.9 µM 0.434205796413562 0.368687802689048 no 1224 0.332069502139896 387 7020 An insecticide.
SGTC_601 0986-0029 62.9 µM 0.4330705328546 0.369020871693738 no 1225 0.332481764732816 372 24747981
SGTC_3087 9117406 49.47 µM 0.432655240672427 0.36914273667163 no 1226 0.332632625697281 318 42546093
SGTC_815 1582-0027 36.9 µM 0.430623609355904 0.369739095948133 no 1227 0.333371035813853 374 3128206
SGTC_2235 salicylic acid 500 µM 0.42993442641549 0.369941468019047 no 1228 0.3336216709362 348 338 A COX inhibitor and kinase inhibitor.
SGTC_1919 st067113 52.3 µM 0.428444103685352 0.370379210331799 no 1229 0.334163910363441 355 1268243
SGTC_712 r015-0009 80.6 µM 0.427911012109583 0.37053583247971 no 1230 0.334357954699228 365 6813872 YLR060W FRS1
SGTC_47 0149-0135 24.25 µM 0.426084360821182 0.371072664699093 no 1231 0.335023187804498 339 5239155
SGTC_677 0929-0063 136 µM 0.422006112409908 0.372272120299338 no 1232 0.336510277971254 371 1539583
SGTC_13 0199-0087 65 µM 0.421539673406109 0.372409384149951 no 1233 0.33668052364468 363 4589825
SGTC_1195 1502-0147 41.1 µM 0.420424708076726 0.372737562233134 no 1234 0.337087610680744 352 817940
SGTC_1082 camptothecin 424.86 nM 0.418584533985878 0.373279399727775 no 1235 0.33775989728748 380 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_236 1509-0011 5.31 µM 0.416240714644169 0.37396989796372 no 1236 0.338616934811867 385 3107280
SGTC_38 0929-0051 58.268 µM 0.415989493582753 0.374043932706302 no 1237 0.338708845640128 396 1379719
SGTC_3069 9117009 49.47 µM 0.414521868679559 0.374476533932698 no 1238 0.339245977392403 346 41904981
SGTC_2927 9011802 47.9 µM 0.413803442224838 0.374688356984324 no 1239 0.339509031419473 358 43912568
SGTC_396 dithiazanine 1.25 µM 0.413006907800139 0.374923253834404 no 1240 0.339800776343862 349 10578 An antihelmenthic.
SGTC_653 0203-0016 55.2 µM 0.412614707917644 0.375038930068044 no 1241 0.339944461816671 387 295302
SGTC_1271 0832-2808 169 µM 0.412364506974672 0.375112730718359 no 1242 0.34003613702564 388 3663794
SGTC_1901 st060216 58.6 µM 0.411405003158234 0.375395793624159 no 1243 0.340387792947275 357 688792
SGTC_2775 cyproheptadine 69.59 µM 0.411289664106044 0.375429824280747 no 1244 0.340430073795484 385 2913 A selective serotonin reuptake inhibitor.
SGTC_7 0192-1582 4.227 µM 0.410391733876167 0.375694790707023 no 1245 0.340759304511396 369 252616
SGTC_1667 st014849 34.6 µM 0.410269146314153 0.375730969102726 no 1246 0.340804261287531 359 5348460
SGTC_469 w7 172 µM 0.409100506909147 0.376075916154179 no 1247 0.341232952142023 373 45115570 A P450 inhibitor.
SGTC_33 0986-0033 35.816 µM 0.408913943480848 0.376130993216484 no 1248 0.341301408011048 359 2848082
SGTC_545 4218-0007 221 µM 0.407827932024018 0.376451654450671 no 1249 0.341700002692433 382 2840508
SGTC_840 0245-0196 390 µM 0.407625394506975 0.376511466144106 no 1250 0.341774358820258 362 3827528
SGTC_3160 9100216 49.47 µM 0.404895195632333 0.377318014568428 no 1251 0.342777275012294 371 17191039
SGTC_1921 5740136 50 µM 0.403672613314035 0.377679360513602 no 1252 0.343226740572109 397 1774243
SGTC_1147 3809-1045 12.3 µM 0.403401121805733 0.377759616976325 no 1253 0.3433265808137 369 325925
SGTC_2302 7771753 200 µM 0.403170716246681 0.377827732031622 no 1254 0.343411320390837 344 2203047
SGTC_3148 9097893 49.47 µM 0.403126653601251 0.377840758753965 no 1255 0.343427526842548 326 17174100
SGTC_2809 7964133 12.99 µM 0.402398863101293 0.378055943515547 no 1256 0.343695253295298 396 1253665
SGTC_3313 9133968 57.047 µM 0.401913604356814 0.378199440293493 no 1257 0.343873805118091 378 1494643
SGTC_2284 7945075 39.21 µM 0.400459958098562 0.378629401253641 no 1258 0.344408885143554 402 1245402
SGTC_8 0354-0001 70 µM 0.400220427456312 0.3787002643048 no 1259 0.344497085118686 379 4993152
SGTC_1935 st074532 41.6 µM 0.399090910665754 0.379034476917586 no 1260 0.344913109678485 416 2829742
SGTC_1226 3909-7979 35.4 µM 0.398863593296892 0.379101748773046 no 1261 0.344996858088276 373 6615510
SGTC_2439 5492030 7.2 µM 0.398780276994285 0.37912640615302 no 1262 0.345027555435406 381 5722370
SGTC_1459 k035-0031 35.7 µM 0.397609251772572 0.379473021937039 no 1263 0.345459119852368 364 3877128 YMR208W ERG12
SGTC_3190 9110366 49.47 µM 0.394573009090857 0.380372180522028 no 1264 0.346579018112673 394 17123768
SGTC_907 3448-6986 75.5 µM 0.394491496019439 0.380396328891723 no 1265 0.34660910221921 379 590582
SGTC_349 k015-0014 24 µM 0.393598468785344 0.380660920057248 no 1266 0.34693875594652 366 2196908
SGTC_2706 st078239 82.5 µM 0.39325585728036 0.38076244575895 no 1267 0.347065258964201 375 15434492
SGTC_2056 5235370 200 µM 0.393168515222 0.380788329051627 no 1268 0.347097511145232 353 5511916
SGTC_2789 5281112 71.43 µM 0.3922456269033 0.381061854025052 no 1269 0.347438367194065 361 765948
SGTC_478 N-arachidonylglycine 10 µM 0.39152100215029 0.38127665944971 no 1270 0.347706083837614 361 5283389
SGTC_2807 7945238 51.95 µM 0.391257505672392 0.381354778568833 no 1271 0.347803452916167 405 17148797
SGTC_649 1123-0311 367 µM 0.390959644999273 0.38144309150327 no 1272 0.347913532582397 380 693629 YIL048W NEO1
SGTC_1227 3909-8010 46.6 µM 0.389962881997337 0.381738667381894 no 1273 0.348281997116509 374 15982272
SGTC_2436 5633522 8.09 µM 0.389658609546666 0.381828908792788 no 1274 0.348394503366337 374 5724242
SGTC_3113 9123498 49.47 µM 0.38831783236782 0.382226634191179 no 1275 0.348890421169834 398 8897275
SGTC_2760 etidronate 98.04 µM 0.388022720839313 0.382314192175778 no 1276 0.348999609777178 383 3305 A chelator and antioxidant.
SGTC_130 0136-0219 337.655 µM 0.385390623904656 0.383095386714469 no 1277 0.34997401408419 413 234244
SGTC_1545 lovastatin 49.4 µM 0.384487263888203 0.383363609712952 no 1278 0.350308666894024 360 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2215 7188065 200 µM 0.38274535406614 0.383880970211413 no 1279 0.350954291359457 400 940217
SGTC_2140 5586273 200 µM 0.381252323584954 0.384324576462568 no 1280 0.351508013519309 379 854421
SGTC_325 2810-4341 181 µM 0.381187232089127 0.384343919770249 no 1281 0.351532161267071 372 774970
SGTC_1954 st077032 68.9 µM 0.380934965851755 0.384418888711764 no 1282 0.351625753061311 403 698907
SGTC_2996 9066192 71.4286 µM 0.380767696939351 0.384468600376806 no 1283 0.351687815463684 360 6472854
SGTC_3355 9151058 44.0485 µM 0.379786222238064 0.384760329068237 no 1284 0.352052055243778 368 17015728
SGTC_2780 5215298 71.43 µM 0.379363984457296 0.384885853026583 no 1285 0.352208795724369 396 2834131
SGTC_3183 9108214 49.47 µM 0.379006286922109 0.384992199732004 no 1286 0.352341597623042 381 4974831
SGTC_1361 1608-0041 5.61 µM 0.378651947480265 0.385097556576381 no 1287 0.352473170519178 375 X1361
SGTC_2010 4012422 159 µM 0.377351314338981 0.385484350517175 no 1288 0.352956271280052 397 952393
SGTC_581 0958-0271 211 µM 0.375889300561945 0.385919273269837 no 1289 0.353499597561467 356 4591145
SGTC_1431 4049-0260 9.09 µM 0.374793505787523 0.38624534654157 no 1290 0.353907022224543 378 3854841
SGTC_2086 5274770 176.623 µM 0.374297906368559 0.38639284738974 no 1291 0.35409134477092 375 689278
SGTC_786 4544-0069 423 µM 0.374264100372917 0.386402909366005 no 1292 0.354103919089231 366 748821 YLR208W SEC13
SGTC_2605 digitonin 300 nM 0.373809027763248 0.386538364067771 no 1293 0.354273201226063 370 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2238 6671620 73.2395 µM 0.373525388693908 0.386622797690334 no 1294 0.354378726492861 341 729941
SGTC_3266 9136860 49.47 µM 0.372996131704417 0.386780361156139 no 1295 0.354575661502802 395 4871271 YPR165W RHO1
SGTC_574 1315-0397 40 µM 0.371844139795034 0.387123381604295 no 1296 0.35500444874567 377 6794277
SGTC_1840 st055363 71 µM 0.368246840698381 0.388195090195009 no 1297 0.35634459329659 379 676033
SGTC_446 go6976 132 µM 0.367961477795324 0.388280142187289 no 1298 0.356450979174549 418 3501 A protein kinase C inhibitor.
SGTC_2933 9026794 32.47 µM 0.366444257528116 0.388732437330018 no 1299 0.357016800064247 414 17586027
SGTC_806 3966-4455 5.86 µM 0.365974657505518 0.388872459347031 no 1300 0.357191993041248 377 714982
SGTC_2435 5706476 10.6 µM 0.362860578000383 0.38980135805436 no 1301 0.358354518340371 372 5725375
SGTC_3135 9127742 49.47 µM 0.36170857498881 0.390145148871647 no 1302 0.358784909219513 377 3643468
SGTC_2771 fluoxetine 41.05 µM 0.361094772297601 0.390328360350658 no 1303 0.359014300546126 411 3386 A selective serotonin reuptake inhibitor.
SGTC_971 1315-0384 26.7 µM 0.359573201925398 0.3907826326816 no 1304 0.359583163364089 404 6769120
SGTC_407 eburnamonine 100 µM 0.357663769931453 0.391352913894841 no 1305 0.360297474631887 370 3195
SGTC_2083 5306046 65.942 µM 0.356224669501784 0.391782877823471 no 1306 0.360836159262758 363 539837
SGTC_1386 3228-0095 33.8 µM 0.355171626380253 0.392097582165611 no 1307 0.361230509839608 409 870181
SGTC_244 nsc-207895 1.295 µM 0.35449181981401 0.392300781422382 no 1308 0.361485166694132 389 42640
SGTC_1299 1079-1439 3.74 µM 0.353243677285245 0.39267393696713 no 1309 0.361952883017942 390 323161
SGTC_3094 9117742 49.47 µM 0.353086313173962 0.392720990922109 no 1310 0.362011866710555 395 17149698
SGTC_679 0422-0091 41.4 µM 0.353051545787797 0.392731387042879 no 1311 0.362024898769579 406 627384 YHR062C RPP1
SGTC_1363 1636-0063 10.4 µM 0.351246002437437 0.393271384438713 no 1312 0.362701900493181 398 6072185
SGTC_2303 7774051 200 µM 0.350797276344423 0.393405620224443 no 1313 0.362870220341355 409 2953184
SGTC_1270 0831-1170 17.3 µM 0.347191947635011 0.394484607919008 no 1314 0.364223559947032 398 6764716
SGTC_561 1550-0330 72.9 µM 0.346537496716471 0.39468055636197 no 1315 0.364469404755045 401 6812934
SGTC_2695 st077686 51.995 µM 0.339523274018382 0.396782340944884 no 1316 0.367107783553751 363 2876092
SGTC_2490 carminic acid 95.39 µM 0.339092986091335 0.396911373400328 no 1317 0.367269841025921 397 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1819 st053448 58.6 µM 0.337741155962095 0.397316826401207 no 1318 0.367779128656782 406 2857616
SGTC_2919 7978188 46.38 µM 0.337014617228845 0.397534782286842 no 1319 0.368052940543169 374 2980291
SGTC_496 calpeptin 138 µM 0.33694852560037 0.397554610842305 no 1320 0.368077851936601 385 73364 A calpain inhibitor.
SGTC_3241 9133421 49.47 µM 0.336401519356843 0.397718731702761 no 1321 0.368284051950058 418 17018221
SGTC_2334 9017922 200 µM 0.335655203704997 0.397942681500078 no 1322 0.368565445029999 398 3163164
SGTC_854 0422-0053 192 µM 0.335187921225518 0.398082917869364 no 1323 0.368741666508123 397 3596728
SGTC_1885 st057546 99.9 µM 0.33397240749875 0.398447767906423 no 1324 0.369200190013285 386 702008
SGTC_909 3448-9333 149 µM 0.333795739966998 0.398500804039131 no 1325 0.369266849128045 392 3344074
SGTC_3172 9105863 49.47 µM 0.333660908316911 0.398541282173787 no 1326 0.369317725628322 409 2348785
SGTC_631 k072-0230 41.5 µM 0.329446036300911 0.399807187337726 no 1327 0.370909288039846 391 5773147
SGTC_256 clotrimazole 625 nM 0.328124281289821 0.400204384209029 no 1328 0.371408847808508 393 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2797 7859098 81.82 µM 0.326638549745074 0.400650980448381 no 1329 0.371970641475405 381 972681
SGTC_616 4092-0450 108 µM 0.324607256873498 0.401261777138369 no 1330 0.372739167116378 410 787165
SGTC_1049 3226-0134 66 µM 0.323608975907692 0.401562042353527 no 1331 0.373117045784252 385 5702385
SGTC_367 0335-0881 7.1 µM 0.32331936646871 0.401649162624073 no 1332 0.373226694326676 425 23828853
SGTC_2456 5770359 74.46 µM 0.319978080974916 0.402654640139253 no 1333 0.374492473285426 437 3118787
SGTC_861 0443-0273 110 µM 0.317139563412354 0.403509328462575 no 1334 0.375568852935799 402 6149169
SGTC_1787 fluconazole 80 µM 0.316763861296476 0.403622488421442 no 1335 0.375711393818102 399 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_181 1447-1644 8.07 µM 0.309843664908789 0.405708257168424 no 1336 0.378339922340025 414 534600
SGTC_1446 4239-0190 62 µM 0.308471482208289 0.40612215756568 no 1337 0.378861798415423 420 1340085
SGTC_2468 5987765 72.9 µM 0.307462947741042 0.4064264353179 no 1338 0.379245510717804 394 26772094
SGTC_1138 3761-0006 1.03 µM 0.305229209695793 0.407100561466161 no 1339 0.380095793545852 416 12061087
SGTC_366 0181-0206 4.31 µM 0.304992843193518 0.407171911325446 no 1340 0.380185801556323 404 274874
SGTC_864 0469-0573 172 µM 0.304330087216779 0.407371988013713 no 1341 0.380438212631512 417 689425
SGTC_1812 st052057 4.327 µM 0.304252729931974 0.40739534266377 no 1342 0.3804676775275 392 3645418
SGTC_733 4069-0007 56.1 µM 0.303803731505125 0.407530904606098 no 1343 0.380638711851361 406 5717425 YNL287W SEC21
SGTC_1443 4112-3303 14 µM 0.302528901268512 0.407915862615282 no 1344 0.381124452481491 409 704433
SGTC_2561 acetosyringone 100 µM 0.302360384475517 0.40796675596523 no 1345 0.381188675423 435 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_74 000s-0487 160.283 µM 0.30205830612959 0.408057989803625 no 1346 0.381303807806421 342 677548
SGTC_2886 9058944 51.95 µM 0.300190757543582 0.408622138165448 no 1347 0.382015827290336 401 4949929
SGTC_2517 totarol 10 µM 0.299106434754508 0.408949776963486 no 1348 0.382429418345089 383 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1559 coumarin 343 70.1 µM 0.297555821228467 0.409418420599957 no 1349 0.383021098730399 402 108770 A hepatotoxic, DNA x-linker.
SGTC_1597 7-benzyloxygramine 47.5 µM 0.29739827475226 0.40946604330212 no 1350 0.383081230341035 414 260807
SGTC_2836 9010338 19.48 µM 0.295415070798602 0.410065634602097 no 1351 0.383838410967896 391 2994051
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.294743169205272 0.410268821515021 no 1352 0.384095041516717 424 756377
SGTC_2822 7994718 71.43 µM 0.289877897938118 0.411740823105706 no 1353 0.385954825445711 443 1018011
SGTC_2324 6149169 200 µM 0.289641132749529 0.411812488965912 no 1354 0.386045397893712 443 2888231
SGTC_143 4032-1194 15.74 µM 0.288714479372954 0.412093003614332 no 1355 0.386399940706555 400 1806963
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.288293942818352 0.41222032242296 no 1356 0.386560871678449 431 1377
SGTC_1276 0871-0068 94.2 µM 0.286387795910645 0.41279753024944 no 1357 0.387290560446422 410 3414906
SGTC_2182 6325192 200 µM 0.286141328450506 0.412872177824338 no 1358 0.387384939366308 426 736248
SGTC_2828 7998861 71.43 µM 0.286086133730638 0.412888895075489 no 1359 0.387406075799166 436 2988188
SGTC_19 0279-0214 38.434 µM 0.284841829355568 0.413265809023015 no 1360 0.387882661939059 408 3566274 YBR002C RER2
SGTC_1336 1486-0901 104 µM 0.28480941988658 0.413275627289618 no 1361 0.387895077483622 393 5006114
SGTC_2902 5787006 60.46 µM 0.281334939859874 0.414328514852825 no 1362 0.389226756959997 409 591003
SGTC_2079 5212404 121 µM 0.280231311850998 0.414663081551059 no 1363 0.389650022636929 404 758462
SGTC_2598 perillyl alcohol 100 µM 0.27753454077804 0.415480872286494 no 1364 0.39068484367583 410 10819 An apoptosis inducer.
SGTC_1627 st003713 25.6 µM 0.275380586333999 0.416134318170787 no 1365 0.391511928785978 402 16195070 YER133W GLC7
SGTC_632 0781-2353 4.65 µM 0.274121196695528 0.416516487178079 no 1366 0.391995742453519 432 6811515 YHR007C ERG11
SGTC_1036 k216-0215 33.5 µM 0.273451140655035 0.416719851716659 no 1367 0.392253222793558 415 622330
SGTC_1045 1348-1485 165 µM 0.272051275272672 0.417144788013174 no 1368 0.392791296814462 392 6810614
SGTC_1366 1683-0113 21.9 µM 0.271692448714814 0.417253727256928 no 1369 0.392929254009086 394 708623
SGTC_3354 9151612 71.43 µM 0.271222198444612 0.417396504201258 no 1370 0.393110070374724 438 27261949
SGTC_3147 9097027 49.47 µM 0.270087050182029 0.417741201693264 no 1371 0.393546642240821 434 25236841
SGTC_1647 st011722 22.4 µM 0.268768751837737 0.418141593591386 no 1372 0.394053820609414 409 2854783
SGTC_2688 kanamycin b 96.69 µM 0.268759868838114 0.418144291812999 no 1373 0.394057238705291 427 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3082 9117008 49.47 µM 0.26404421998634 0.419577216501434 no 1374 0.395872922425908 405 41448529
SGTC_1506 4226-2149 212 µM 0.263047305551166 0.419880282039999 no 1375 0.396257059014082 428 991114
SGTC_382 3229-0966 23.2 µM 0.262161296643812 0.420149671794058 no 1376 0.39659854544036 442 5722370
SGTC_987 1497-1013 404 µM 0.25963346459086 0.42091846077716 no 1377 0.397573260142876 463 1676435
SGTC_2315 7733312 200 µM 0.259207870179533 0.421047926458443 no 1378 0.397737429527039 398 726316
SGTC_1395 3486-0190 4.35 µM 0.256969211001458 0.421729066106755 no 1379 0.398601270600307 434 6748079
SGTC_1173 0443-0020 122 µM 0.256013741187911 0.422019851016117 no 1380 0.398970113446953 435 5331295
SGTC_2389 9091542 195.52 µM 0.255857062351821 0.422067538260054 no 1381 0.399030605262827 418 3626624 YOL127W RPL25
SGTC_54 0159-0055 9 µM 0.254654531432427 0.422433582192569 no 1382 0.399494968629597 439 3319099
SGTC_1613 st002381 52.1 µM 0.253225145654294 0.422868766648483 no 1383 0.400047118090181 412 551167
SGTC_2343 7990716 14.84 µM 0.252813272908119 0.42299418109368 no 1384 0.400206255259937 431 6456862
SGTC_1170 0310-0127 64.8 µM 0.24817742503085 0.424406323061265 no 1385 0.401998566135502 453 774975
SGTC_2482 5981709 142.65 µM 0.244973732056534 0.425382779740101 no 1386 0.403238385265469 443 877755
SGTC_214 4373-3496 70 µM 0.244895063703583 0.425406762927424 no 1387 0.403268841965045 454 3779166
SGTC_1427 4048-4900 550 nM 0.244855183315653 0.425418921146997 no 1388 0.403284282006448 446 24132586
SGTC_2536 dehydroabietamide 32.04 µM 0.243182318959523 0.425928986253532 no 1389 0.403932081614154 423 3983547
SGTC_3289 9119912 71.43 µM 0.243005038045073 0.425983047411987 no 1390 0.404000747311182 431 17014829
SGTC_3280 9140961 49.47 µM 0.242970033859659 0.425993721973211 no 1391 0.404014305729507 426 4901226
SGTC_1973 st070275 50.2 µM 0.242052177884662 0.426273642397948 no 1392 0.404369866473509 443 17118334
SGTC_845 0330-0138 4.51 µM 0.240737487455013 0.426674650917987 no 1393 0.404879291234003 465 9039800
SGTC_399 oxolinic acid 75 µM 0.23953110344864 0.427042690383804 no 1394 0.405346890616761 426 4628 A DNA gyrase inhibitor.
SGTC_2623 humulene 100 µM 0.2367812590645 0.427881840315179 no 1395 0.406413245635754 409 6187145 An anti-inflammatory.
SGTC_351 caspofungin 25 nM 0.235078106582466 0.4284017427994 no 1396 0.407074055506062 420 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_614 0462-0418 107 µM 0.234402293028464 0.428608075408316 no 1397 0.40733633932568 448 5188303
SGTC_1168 k815-0004 80.5 µM 0.23326250847282 0.428956107167568 no 1398 0.407778784765523 435 642433
SGTC_1774 st048371 48.465 µM 0.232397052082558 0.429220410085728 no 1399 0.408114819177251 444 4242727
SGTC_73 0327-0325 16.231 µM 0.23206541319773 0.429321698158055 no 1400 0.40824360393554 435 53298
SGTC_2025 5147754 141 µM 0.231416419269836 0.429519925235875 no 1401 0.408495655297646 460 315777 YLR208W SEC13
SGTC_2142 5622915 118.518 µM 0.231166700565338 0.429596203428188 no 1402 0.408592649254283 435 5322196
SGTC_21 0849-0113 22.993 µM 0.229672975983112 0.430052526043575 no 1403 0.409172947812869 428 1560156
SGTC_252 miconazole 1.30953 nM 0.228612647779685 0.430376505784319 no 1404 0.409584996688855 453 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1527 coumarin 137 µM 0.227246158992581 0.430794100969148 no 1405 0.410116168370372 476 323 A hepatotoxic, DNA x-linker.
SGTC_801 0866-0028 10.1 µM 0.224207627033107 0.431722944626625 no 1406 0.411297874512436 460 6849771
SGTC_2895 9054447 58.44 µM 0.223887147200481 0.431820933663798 no 1407 0.411422558470048 424 2697450
SGTC_2197 6588183 93.1375 µM 0.223518021167159 0.431933801828459 no 1408 0.411566179512026 422 884136
SGTC_2216 7189485 200 µM 0.222448826865989 0.43226076213423 no 1409 0.411982252739393 447 731273
SGTC_822 1487-0950 154 µM 0.222249901433335 0.432321598785419 no 1410 0.412059674809974 455 1958375
SGTC_1451 4152-0210 104 µM 0.221887977832352 0.432432288696096 no 1411 0.412200544784322 463 659563
SGTC_2294 7971431 200 µM 0.221653531613495 0.432503994038049 no 1412 0.412291803321708 463 5741572
SGTC_2003 4023581 200 µM 0.22131590555769 0.432607260823323 no 1413 0.412423233094435 438 16641307
SGTC_189 3970-0742 2.116 µM 0.220813558120614 0.432760918042293 no 1414 0.412618803145945 465 2891807
SGTC_1794 st048918 76.9 µM 0.220364761697105 0.4328982037647 no 1415 0.412793543478017 452 672303
SGTC_694 1315-0438 43.2 µM 0.218496485594022 0.433469791684319 no 1416 0.413521148132546 447 6793154
SGTC_2283 7944793 200 µM 0.21829992769069 0.433529935513727 no 1417 0.413597715397755 475 2970533
SGTC_2165 5727197 32.143 µM 0.216062187968432 0.434214759157556 no 1418 0.414469636590822 448 1361712
SGTC_2954 9074818 52.69 µM 0.215478823551427 0.434393320830276 no 1419 0.414697010322978 458 16648742
SGTC_729 4092-0585 94.1 µM 0.213655981094823 0.434951359706461 no 1420 0.41540767031234 413 2169061
SGTC_642 0335-0876 158 µM 0.212657097242322 0.435257209697109 no 1421 0.415797216359738 467 6812350
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.210937076418981 0.435783956556606 no 1422 0.416468186088536 427 3256 An antibiotic and ribosome inhibitor.
SGTC_1762 st045503 25.4615 µM 0.210222548961114 0.436002810187869 no 1423 0.416746990623238 446 4645554
SGTC_68 0986-0284 82.829 µM 0.209746887245913 0.436148512160565 no 1424 0.416932614338074 438 423278 YIL048W NEO1
SGTC_495 decylubiquinone 155 µM 0.209171191618998 0.436324867536922 no 1425 0.417157300367861 472 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1712 st032288 53.4 µM 0.20866863205624 0.43647882917064 no 1426 0.417353464527471 460 2883011
SGTC_235 0330-0087 5 mM 0.206886750840541 0.437024794783628 no 1427 0.418049151984601 445 46494818 YHR062C RPP1
SGTC_2864 9034755 47.6 µM 0.20570686289191 0.437386376682492 no 1428 0.418509948699006 431 4930451
SGTC_1695 st026914 34.495 µM 0.204190402317412 0.437851179523378 no 1429 0.419102355600922 438 3289191
SGTC_218 alverine citrate 93.75 µM 0.203832732555531 0.437960819638732 no 1430 0.419242106453073 460 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1328 1441-0025 69.2 µM 0.203639305019866 0.438020114914719 no 1431 0.419317687853912 435 4562601
SGTC_879 0831-1030 162 µM 0.202912976485567 0.438242783584015 no 1432 0.419601525750935 467 1549252
SGTC_3273 9137859 49.47 µM 0.202427333444018 0.43839167683315 no 1433 0.419791330846557 467 2377234
SGTC_1027 k015-0025 8.67 µM 0.202285032446861 0.438435306533884 no 1434 0.419846950241265 418 3598955
SGTC_707 0865-0008 204 µM 0.200721282192843 0.438914803898416 no 1435 0.420458258796485 474 723043
SGTC_1419 3993-2473 62.6 µM 0.200043894838557 0.439122541058896 no 1436 0.420723125880326 454 704026
SGTC_742 0kpi-0133 140 µM 0.199907100936418 0.439164494243247 no 1437 0.420776618398417 471 2728852
SGTC_759 3486-0358 89.3 µM 0.199725190887165 0.439220285111944 no 1438 0.420847755608567 467 875103
SGTC_2650 prasterone 100 µM 0.19838589819392 0.439631076331515 no 1439 0.421371574895639 462 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_10 0279-0212 42.575 µM 0.198054130289851 0.439732847080241 no 1440 0.421501356298112 446 39851 YBR002C RER2
SGTC_2497 7-hydroxyflavone 100 µM 0.19754031649543 0.43989046878186 no 1441 0.421702367475939 469 5281894
SGTC_2733 amorolfine 100 µM 0.197343914396731 0.439950721206635 no 1442 0.421779208130202 483 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2259 7964009 200 µM 0.196874804707086 0.44009464075403 no 1443 0.421962755362136 423 313134
SGTC_1465 k213-0056 144 µM 0.196267275904092 0.440281038071009 no 1444 0.422200486640077 456 24048857 YMR208W ERG12
SGTC_3119 9125183 49.47 µM 0.196245157915172 0.440287824392283 no 1445 0.422209142135871 467 22695334
SGTC_1671 st016596 74.5 µM 0.194878683849986 0.440707124842297 no 1446 0.42274396103629 454 2829167
SGTC_1306 1185-0270 9.02 µM 0.193222165078027 0.441215514171824 no 1447 0.423392490299455 463 1548076
SGTC_1012 4112-3522 18 µM 0.193116039599612 0.441248087630399 no 1448 0.423434045657534 446 3112398
SGTC_589 1227-0070 34.1 µM 0.191823965482041 0.441644700198843 no 1449 0.423940048910529 455 2841384
SGTC_2910 7948405 25.97 µM 0.18886465759098 0.442553303482252 no 1450 0.425099447086953 479 2971328
SGTC_3243 9134147 49.47 µM 0.188701406357374 0.442603435733937 no 1451 0.42516342463908 469 24282180
SGTC_2309 7664088 163.95 µM 0.186174657186702 0.44337948302871 no 1452 0.426153898568316 471 704922
SGTC_2128 5255449 168.493 µM 0.184623966718183 0.443855858533493 no 1453 0.426761993186514 429 736008
SGTC_2127 5253358 187.912 µM 0.1839264142767 0.444070174669007 no 1454 0.427035591349114 457 20612
SGTC_1201 1889-3372 45.9 µM 0.183449058817372 0.444216846875112 no 1455 0.427222842782343 452 5392199
SGTC_576 1073-0113 22.7 µM 0.182151442263855 0.444615591004002 no 1456 0.427731939428699 475 5439563
SGTC_803 4488-1585 147 µM 0.181938533263693 0.444681021098901 no 1457 0.427815481981908 473 747204
SGTC_3198 9112019 49.47 µM 0.181001744782357 0.444968927982798 no 1458 0.428183103248818 489 45595555
SGTC_2560 caryophyllene 100 µM 0.180716113455866 0.445056717962834 no 1459 0.428295205162196 438 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_422 cantharidin 155 µM 0.180408999159875 0.445151113829485 no 1460 0.42841574496626 478 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.179460949340128 0.445442529773531 no 1461 0.428787888709587 470 676296 Flavone; oxidizing agent.
SGTC_2502 avocadyne acetate 18.59 µM 0.176055309526958 0.446489613175569 no 1462 0.430125245134911 443 3952079
SGTC_2431 5490079 200 µM 0.176041939604831 0.446493724574661 no 1463 0.430130496943311 474 5722345
SGTC_1798 st045719 60.953 µM 0.173901946814766 0.44715186989273 no 1464 0.43097126130313 484 3980186
SGTC_2531 methyl deoxycholate 70.07 µM 0.171937859164002 0.447756044515667 no 1465 0.431743191232669 467 16667744 Haematoxylin.
SGTC_2852 9023854 51.95 µM 0.170972733689899 0.448052972067801 no 1466 0.432122602626279 495 19798528
SGTC_835 0312-0010 67.2 µM 0.170376028989095 0.448236566983688 no 1467 0.432357211305807 454 1626196
SGTC_1956 st077085 54 µM 0.169681622876162 0.448450236760392 no 1468 0.432630263649775 484 24208685
SGTC_1675 st018485 24.5 µM 0.169664605836187 0.448455473116466 no 1469 0.432636955444965 490 3323024
SGTC_2821 7996764 71.43 µM 0.169178853864399 0.448604948857929 no 1470 0.432827981100937 440 2987135
SGTC_1485 3909-9022 254 µM 0.168666275120582 0.448762687652964 no 1471 0.433029573611485 477 714516
SGTC_1684 st024538 14.6195 µM 0.168524117551535 0.448806436052283 no 1472 0.43308548596671 453 6732859
SGTC_2383 9036125 200 µM 0.168436327386431 0.448833453420593 no 1473 0.43312001560905 486 79580
SGTC_2787 5284540 71.43 µM 0.167772827761501 0.449037652678808 no 1474 0.433380999885743 471 736958
SGTC_187 1488-2104 32.728 µM 0.166396895868968 0.449461153713523 no 1475 0.433922308319994 483 2852859
SGTC_22 0964-0034 14.468 µM 0.165259824643596 0.449811178781968 no 1476 0.43436973962918 482 138402
SGTC_1669 st015249 58.4 µM 0.163616449783873 0.450317128426046 no 1477 0.435016547084744 482 722793
SGTC_3093 9117344 49.47 µM 0.161797890458823 0.45087710661519 no 1478 0.435732507162444 443 24824913
SGTC_2234 tolnaftate 200 µM 0.161272532605256 0.451038895198052 no 1479 0.4359393779326 480 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_451 chloral hydrate 100 µM 0.161140125729912 0.451079672347163 no 1480 0.435991518708868 486 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1777 st045864 34.765 µM 0.159069493846053 0.45171742867548 no 1481 0.436807061273524 479 4691462
SGTC_1771 st048882 4.1505 µM 0.157592749082648 0.452172343514171 no 1482 0.437388858783593 430 4580403
SGTC_2029 5175081 200 µM 0.156173397854801 0.452609637327329 no 1483 0.437948172429627 451 1380876
SGTC_2432 5630864 12.22 µM 0.155701564832084 0.452755019080128 no 1484 0.438134131828874 463 5714970
SGTC_282 k297-0036 65.7 µM 0.154432805816692 0.453145981978762 no 1485 0.438634244309236 470 5061378
SGTC_506 n9-isopropylolomoucine 153 µM 0.152424028990122 0.453765071074336 no 1486 0.439426253055334 490 6610355
SGTC_3111 9122088 49.47 µM 0.149330111350573 0.454718811255988 no 1487 0.440646578113364 494 16876704
SGTC_730 1436-0052 41.2 µM 0.1486662122879 0.454923500952355 no 1488 0.440908511794583 449 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3306 9127676 59.7925 µM 0.148381022355238 0.455011432817258 no 1489 0.441021038122447 452 41905287
SGTC_2839 9003951 25.97 µM 0.147217005031336 0.455370354044052 no 1490 0.441480369382217 493 2990634
SGTC_2922 7999257 32.47 µM 0.146813018533969 0.455494930591617 no 1491 0.441639804365108 496 2988377
SGTC_471 1-acyl-paf 4 µM 0.146789761743885 0.455502102377058 no 1492 0.441648983043963 451 16759367
SGTC_2576 guaiol 23.12 µM 0.146265364221008 0.455663816695153 no 1493 0.441855953554176 450 227829
SGTC_1393 3470-5649 58.2 µM 0.146146568626897 0.455700452040155 no 1494 0.441902842300374 489 4108395
SGTC_1092 toremifene 6.32 µM 0.145925534811824 0.455768617607993 no 1495 0.441990086746104 494 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1717 st033143 58.0435 µM 0.145269236629974 0.45597102388874 no 1496 0.442249151327863 489 674616
SGTC_3290 9121031 71.43 µM 0.144254774739061 0.456283912461492 no 1497 0.442649644612863 484 17014854
SGTC_1357 1503-1303 39.5 µM 0.143914818519757 0.45638877059288 no 1498 0.442783867008121 474 292895
SGTC_850 0388-0143 75.9 µM 0.142845092334901 0.456718743121936 no 1499 0.443206261844143 464 67273
SGTC_2390 9097792 176.6 µM 0.142414792993304 0.456851483613967 no 1500 0.443376189181558 439 4497149
SGTC_1457 k015-0032 57.3 µM 0.142024427898116 0.456971909192717 no 1501 0.443530355297267 477 4302660
SGTC_2582 agaric acid 100 µM 0.140173531372994 0.457542954635392 no 1502 0.444261442156177 476 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2272 7805186 180 µM 0.138947083113167 0.457921391352126 no 1503 0.444745982425576 503 2956062 YPR165W RHO1
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.138743609798486 0.45798417941435 no 1504 0.444826377854026 484 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2929 9013348 24.6 µM 0.138665650765344 0.458008236392921 no 1505 0.444857181265682 477 2995952
SGTC_2614 arthonioic acid 13.39 µM 0.138652063203104 0.458012429324874 no 1506 0.444862550058921 460 6710684
SGTC_3022 9087993 49.47 µM 0.136991998459056 0.458524737139502 no 1507 0.445518559893841 503 17173644
SGTC_372 0155-0182 15.9 µM 0.136764913393678 0.458594822585754 no 1508 0.445608309020228 474 771486
SGTC_812 4251-0442 148 µM 0.133590171314074 0.459574779590228 no 1509 0.446863328337618 497 5723007
SGTC_1783 st039459 87.517 µM 0.132728320953584 0.459840852128978 no 1510 0.447204122069988 506 729761
SGTC_1294 1000-1494 117 µM 0.131721767978774 0.460151620371612 no 1511 0.447602183591706 473 712797 YDL207W GLE1
SGTC_1238 0333-0287 48.8 µM 0.130945550574825 0.460391290283443 no 1512 0.447909190367326 470 7226
SGTC_1380 2291-0730 164 µM 0.130814330834264 0.460431807964604 no 1513 0.447961093025882 455 2999191
SGTC_250 brefeldin a 552.239 µM 0.130720765466361 0.460460699080047 no 1514 0.447998102417375 489 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2721 ifenprodil 61.44 µM 0.130658381290705 0.460479962182559 no 1515 0.448022778469712 479 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2101 5377231 179.231 µM 0.130466178202837 0.460539311594616 no 1516 0.448098805639466 484 2844213
SGTC_2355 9061122 103.12 µM 0.13045032893737 0.460544205647785 no 1517 0.448105075003661 489 5302957
SGTC_1879 gemcitabine 100 µM 0.129057548747456 0.460974301851134 no 1518 0.448656056105235 483 60750 A nucleoside analog which inhibits DNA replication.
SGTC_477 mead ethanolamide 10 µM 0.126931395419873 0.461630954544872 no 1519 0.449497348828901 478 16061185
SGTC_3109 9122853 49.47 µM 0.12590857879663 0.461946884140601 no 1520 0.44990214591246 505 1234709
SGTC_2464 5717415 7.67 µM 0.125857695755831 0.461962601622219 no 1521 0.449922285106446 446 5285744
SGTC_2289 7946404 165.07 µM 0.125545197329116 0.462059131908876 no 1522 0.450045972884403 468 1246120 YPR165W RHO1
SGTC_2114 5491910 81.25 µM 0.122687167649055 0.462942075885978 no 1523 0.451177412912624 516 2849228
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.121044865828218 0.463449522473866 no 1524 0.451827749320197 498 364106
SGTC_2337 9009472 200 µM 0.120653527473573 0.463570448951244 no 1525 0.451982734847337 498 5742383
SGTC_1257 0669-0121 16 µM 0.119889464830908 0.463806559711517 no 1526 0.452285355062872 486 4307855
SGTC_3322 9139058 2.11 µM 0.119788040229393 0.463837902918379 no 1527 0.452325528117311 462 4908926 YPR165W RHO1
SGTC_1604 st002052 72.4 µM 0.119348513327629 0.463973732344576 no 1528 0.452499625027213 477 6254834 YHR062C RPP1
SGTC_2441 5730946 39.09 µM 0.119092409111759 0.464052879582273 no 1529 0.452601072297588 478 1774275
SGTC_172 1112-0046 2.638 µM 0.118424054826852 0.464259436546973 no 1530 0.452865833445043 481 2802135 YIL048W NEO1
SGTC_1797 st048695 56.8 µM 0.117003274663648 0.464698564999234 no 1531 0.453428729250541 491 592262 YIL048W NEO1
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.116833131064635 0.464751155124211 no 1532 0.453496144369732 491 688801
SGTC_2279 7948423 32.93 µM 0.11666122479226 0.464804290703802 no 1533 0.45356425926489 480 1247112
SGTC_1851 st056236 18.9 µM 0.115656956008635 0.465114718905159 no 1534 0.45396221068404 489 5393171
SGTC_2667 digitoxin 100 µM 0.11542532982643 0.465186319589426 no 1535 0.454054001419837 498 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_184 1494-0393 24.714 µM 0.114785153529953 0.465384217844066 no 1536 0.454307708517618 479 3090647
SGTC_1488 4013-0813 75.9 µM 0.11307982344267 0.465911429662489 no 1537 0.454983635470129 496 2910057
SGTC_2102 5377816 72.7585 µM 0.111924964590013 0.466268494421239 no 1538 0.455441451044785 510 1379702
SGTC_3213 9129884 49.47 µM 0.111880361683307 0.466282285506745 no 1539 0.45545913396817 465 17190742
SGTC_1087 pterostilbene 9.05 µM 0.111029507504275 0.466545374810717 no 1540 0.455796473891713 495 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1079 idarubicin 2.36 µM 0.110373725546342 0.466748156575085 no 1541 0.456056494886683 511 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_749 1000-0129 128 µM 0.110004799666918 0.46686224012065 no 1542 0.456202784217628 489 708470
SGTC_2067 5224629 34.075 µM 0.109641108703177 0.466974707529614 no 1543 0.456347003570881 470 2835000
SGTC_2001 4023502 57.655 µM 0.107301273728624 0.467698338287278 no 1544 0.457274987044354 492 108941 YCR052W RSC6
SGTC_2515 chrysin 20.77 µM 0.106494459541332 0.467947883134624 no 1545 0.457595025529168 490 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_518 1021-0119 62.6 µM 0.106266692420554 0.468018333004137 no 1546 0.457685378758427 478 1097762
SGTC_1076 itraconazole 331 nM 0.105242197607286 0.468335228346198 no 1547 0.458091813885478 486 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2718 lomofungin 53.02 µM 0.103519164287247 0.468868239817605 no 1548 0.458775470151252 497 5351222 A RNA synthesis inhibitor.
SGTC_3230 9131665 49.47 µM 0.10336164408706 0.468916970677563 no 1549 0.458837976317532 505 15943720
SGTC_1153 4055-0057 267 µM 0.102543784402226 0.469169993351988 no 1550 0.459162530532981 499 882706
SGTC_269 exalamide 29 µM 0.102309700293478 0.469242414656601 no 1551 0.459255427995899 485 3316 A derivative of salicylamide.
SGTC_1244 0416-0015 52.5 µM 0.101075282500846 0.469624337524407 no 1552 0.459745349624898 495 96201
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.100665365650289 0.469751170005303 no 1553 0.459908052939149 479 6857784
SGTC_1650 st011916 45.8 µM 0.100470746428493 0.469811388265378 no 1554 0.459985303134075 506 242528
SGTC_164 4100-3994 89.624 µM 0.10017397692376 0.469903214764581 no 1555 0.460103102740975 523 4615967
SGTC_767 0929-0023 86 µM 0.0988014158442294 0.470327933723853 no 1556 0.460647972157361 510 1204563
SGTC_2310 7668677 200 µM 0.0976081376543865 0.470697203662442 no 1557 0.461121731226247 513 2197143
SGTC_2181 6316240 54.2555 µM 0.0952181987265775 0.471436865752971 no 1558 0.462070757584411 484 12779990
SGTC_1720 st037298 9.481 µM 0.0942595046190519 0.471733599782712 no 1559 0.462451508637493 502 597396
SGTC_2113 5491891 107.031 µM 0.0940844396392066 0.471787787417211 no 1560 0.462521040458484 493 789979
SGTC_1283 0922-0125 16.4 µM 0.0937905849863161 0.471878745037524 no 1561 0.462637755404392 497 3360884
SGTC_1825 st052143 62.6 µM 0.0913239169690958 0.472642316786676 no 1562 0.463617607199886 496 674173
SGTC_2141 5621638 7.665 µM 0.0891541064661411 0.473314077746551 no 1563 0.464479718904079 507 2856238
SGTC_3150 9097574 49.47 µM 0.0881103804503245 0.473637236522806 no 1564 0.464894473031875 501 17217476
SGTC_2952 9073731 13.78 µM 0.0871962780592179 0.473920275450383 no 1565 0.465257748884278 480 16457353
SGTC_1415 3966-0071 78.1 µM 0.0870760689583417 0.473957497487536 no 1566 0.465305523662286 516 2893185
SGTC_2144 5628481 200 µM 0.0868770274404537 0.474019130016122 no 1567 0.465384629956206 505 2818399
SGTC_3331 9141060 1.957 µM 0.0866603475445854 0.474086224915323 no 1568 0.465470747934132 482 4906567 YPR165W RHO1
SGTC_699 0375-0592 111 µM 0.0858951775209609 0.474323165573456 no 1569 0.465774872562358 518 762578
SGTC_2158 5657123 3.6195 µM 0.0844390704037597 0.474774085122734 no 1570 0.466353672250032 514 2858827
SGTC_2994 9053520 71.4286 µM 0.0836194827319193 0.475027904947999 no 1571 0.466679488103112 499 4647384
SGTC_2526 patulin 37.61 µM 0.0823659312685238 0.475416139501072 no 1572 0.467177863438957 498 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2513 baicalein 25.65 µM 0.0791914816637669 0.476399394580052 no 1573 0.468440159981085 505 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1420 4'-methoxyflavone 42 µM 0.0790921522714945 0.476430163249113 no 1574 0.468479662769994 513 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2863 9028737 58.44 µM 0.0776533343801911 0.476875872891501 no 1575 0.469051907863206 516 6460917
SGTC_2725 haloperidol 53.21 µM 0.0762368985403096 0.477314677398012 no 1576 0.469615313652846 513 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1678 st019265 80.2 µM 0.074142780298635 0.477963474651502 no 1577 0.470448387579623 512 5367020
SGTC_2682 pyrogallin 40.03 µM 0.0734675456600402 0.478172687589359 no 1578 0.470717034536611 507 822798 An ATP competetive kinase inhibitor.
SGTC_1886 st057356 49.9 µM 0.0713785424089252 0.478819976739566 no 1579 0.471548243360126 495 24207747
SGTC_2521 angolensin 13.4 µM 0.0712871532333298 0.478848295466307 no 1580 0.471584609725577 520 821428 A flavenoid.
SGTC_2768 sulfasalazine 50.2 µM 0.071105543454789 0.478904571131452 no 1581 0.471656878150934 513 5384001 An antioxidant and salicylic acid derivative.
SGTC_1381 2324-0066 62.1 µM 0.0708424024985246 0.478986111717602 no 1582 0.471761592133255 511 10885928
SGTC_2164 5685496 200 µM 0.0704914058457958 0.479094877883431 no 1583 0.471901270338513 495 759046
SGTC_151 3013-0144 2.285 µM 0.0701721607641756 0.479193806285744 no 1584 0.472028316090245 523 906558 YHR107C CDC12
SGTC_2160 5660466 132.927 µM 0.0699003646813721 0.479278032093249 no 1585 0.472136481433692 524 2859134
SGTC_1691 st019933 84.6 µM 0.0679859157044306 0.479871319073905 no 1586 0.472898422990945 522 6176082
SGTC_2552 juarezic acid 87.02 µM 0.0673339853611358 0.480073362274123 no 1587 0.473157910933011 495 1549512
SGTC_2421 5690543 90.72 µM 0.0673168956677716 0.480078658700979 no 1588 0.473164713300174 516 3397993
SGTC_1991 st073000 8.92 µM 0.066275229099126 0.480401497944324 no 1589 0.473579352085418 517 4301969 YIL048W NEO1
SGTC_1455 4262-0120 131 µM 0.0655568282696739 0.480624156329335 no 1590 0.473865330591815 496 1529587
SGTC_2326 6164455 177.58 µM 0.0635224589344755 0.481254713490867 no 1591 0.474675237856543 501 2888790
SGTC_544 k015-0020 52.4 µM 0.0627045491591957 0.481508239696694 no 1592 0.475000887409815 525 3008304
SGTC_1732 st034308 51.822 µM 0.0626819917436645 0.481515231889732 no 1593 0.475009868848721 511 830119
SGTC_940 3232-1287 54.8 µM 0.0618451094689733 0.481774646921215 no 1594 0.475343090028139 519 1585493 YIL048W NEO1
SGTC_1534 6-azauridine 81.6 µM 0.060996488020055 0.482037708717457 no 1595 0.475681003001728 522 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2634 4'-methoxyflavone 100 µM 0.0608852992077034 0.48207217640925 no 1596 0.475725278628435 507 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_608 k048-0125 159 µM 0.0607873151887139 0.48210255082595 no 1597 0.475764296326202 519 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_668 1682-0499 62.6 µM 0.060760232166068 0.482110946407395 no 1598 0.475775080954364 526 682214
SGTC_2611 pyromycin 23.93 µM 0.0596538002015609 0.482453940700733 no 1599 0.476215684130965 513 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_645 0845-0943 5.41 µM 0.0575230524942344 0.483114509596948 no 1600 0.477064271637173 513 1885106
SGTC_3336 9143619 71.43 µM 0.0574223261923763 0.483145737666324 no 1601 0.477104389306435 531 45595730
SGTC_488 nitrendipine 139 µM 0.0571540812065505 0.483228901880821 no 1602 0.477211228109362 529 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2022 5136654 200 µM 0.0569609120821435 0.483288790716131 no 1603 0.477288166100209 516 1713771
SGTC_1460 k062-0059 9.15 µM 0.0566463446793155 0.483386317850435 no 1604 0.477413458036822 489 1373085
SGTC_928 2764-0428 58.7 µM 0.0550747704629139 0.483873576781897 no 1605 0.478039447941874 521 662578
SGTC_2564 betulinic acid 100 µM 0.0537457760746613 0.484285643843164 no 1606 0.478568855724577 500 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1180 1193-0155 285 µM 0.0534943018513201 0.48436361766494 no 1607 0.478669035307283 518 2921347
SGTC_1140 3229-1848 2.98 µM 0.053046725310991 0.484502397792847 no 1608 0.478847339340961 527 2849525
SGTC_356 1634-0012 32.5 µM 0.0529112980919832 0.484544390102569 no 1609 0.47890129121594 526 735457
SGTC_418 lividomycin a 100 µM 0.052656535894645 0.484623385418532 no 1610 0.479002785140866 504 72394 An antibiotic.
SGTC_2260 7964312 200 µM 0.0523997452561493 0.484703010313528 no 1611 0.479105088548026 498 231951
SGTC_275 trichlorophene 5.69 µM 0.0513245867151288 0.485036398936571 no 1612 0.479533438277277 528 62616
SGTC_1475 4092-1048 11.7 µM 0.0512979522161654 0.485044657981521 no 1613 0.479544049926411 510 2881759
SGTC_1963 st076565 50.3 µM 0.0506331815310504 0.485250797623604 no 1614 0.47980891084447 517 4914280
SGTC_3153 9100258 49.47 µM 0.0505613679478704 0.485273066631755 no 1615 0.479837523670029 522 25236848
SGTC_357 1325-0123 420 µM 0.050036476735353 0.485435833980367 no 1616 0.480046660241677 522 1098503
SGTC_3184 9108758 49.47 µM 0.0492005388817502 0.485695061051571 no 1617 0.480379740911418 525 902885
SGTC_1846 st056244 14.8 µM 0.0489381590230093 0.485776427158317 no 1618 0.480484289388537 505 5393182
SGTC_70 0141-0289 43.283 µM 0.0477710267065261 0.486138371415372 no 1619 0.480949363761399 523 352408
SGTC_1706 st031321 9.9705 µM 0.0462572791207792 0.486607822941195 no 1620 0.481552594579392 524 6103185
SGTC_449 xestospongin c 11.1929 µM 0.0462190556779937 0.48661967724339 no 1621 0.481567827234649 526 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1925 st057770 10.1 µM 0.0439248245614729 0.487331212368284 no 1622 0.482482163627937 489 5989122
SGTC_2495 cafestol 54.53 µM 0.0431080583689935 0.487584534901081 no 1623 0.482807697811415 520 16667697 An anti-infammatory.
SGTC_32 0928-0142 34.1 µM 0.0429165862478162 0.487643921293689 no 1624 0.482884013508989 525 2244242
SGTC_466 geldanamycin 89.2 µM 0.0428219072937636 0.48767328672246 no 1625 0.4829217502551 532 5288382 HSP90 inhibitor.
SGTC_353 1988-1175 58.3 µM 0.041079576836779 0.48821369610351 no 1626 0.483616228090583 518 2788357
SGTC_1626 st003712 1.76 µM 0.0406730243108818 0.488339797490921 no 1627 0.483778283637649 528 24207035
SGTC_995 3931-2021 34.6 µM 0.0406372219955265 0.488350902438327 no 1628 0.483792554896059 526 730143
SGTC_655 k060-0012 42 µM 0.0406119281400363 0.488358747940135 no 1629 0.483802637361185 527 5994525
SGTC_2364 9055074 200 µM 0.0403367550814286 0.488444099818414 no 1630 0.483912325647383 520 6470630
SGTC_1539 benzyladenosine 56 µM 0.0402757972427462 0.488463007504346 no 1631 0.483936624560575 514 92208 A nucleotide analog.
SGTC_3129 9127257 49.47 µM 0.0402236232060685 0.488479190682361 no 1632 0.483957422136474 518 837894
SGTC_2908 7930301 100 µM 0.0390065667200762 0.488856698747457 no 1633 0.484442576557116 516 2223178
SGTC_2705 st078069 42.8 µM 0.038149842588628 0.489122444490751 no 1634 0.484784105785574 519 1530061
SGTC_1007 4101-0031 70 µM 0.0365255857161979 0.489626283017616 no 1635 0.485431638933173 532 1146276
SGTC_833 3852-0053 558 µM 0.0361016450844229 0.489757790604126 no 1636 0.485600655298419 524 3123681
SGTC_2485 5633444 17.78 µM 0.0321710088327151 0.490977136262435 no 1637 0.487167837903581 533 5724239
SGTC_3155 9099265 49.47 µM 0.0321709588204917 0.49097715177758 no 1638 0.487167857845249 530 25236499
SGTC_2043 5101342 149 µM 0.0315544012609707 0.491168425645458 no 1639 0.487413703893284 534 678451
SGTC_1444 4112-3581 28 µM 0.0282707294758965 0.492187148110491 no 1640 0.488723112879819 534 2877249
SGTC_3011 9081274 71.4286 µM 0.0255469668552704 0.493032203969897 no 1641 0.489809343281939 531 6625322
SGTC_538 2922-0838 53.3 µM 0.0255340831907407 0.493036201244351 no 1642 0.489814481444314 513 777039
SGTC_2150 5556613 200 µM 0.0238062655555869 0.493572278601862 no 1643 0.490503571138176 536 743190
SGTC_286 k060-0067 22.9 µM 0.0238011916925642 0.493573852849851 no 1644 0.490505594743275 528 5985051
SGTC_3134 9127454 49.47 µM 0.0230709371884401 0.493800427141107 no 1645 0.490796844138733 535 24262820
SGTC_1109 tnp00067 928.257 nM 0.0223849665029806 0.494013263422635 no 1646 0.491070436170468 540 676295
SGTC_1553 gossypol 38.6 µM 0.0199218533954074 0.494777507705065 no 1647 0.492052856057493 538 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_736 0958-0254 92.6 µM 0.0180931821321032 0.495344912618333 no 1648 0.492782258466524 540 6812352
SGTC_1632 st005650 90 µM 0.0173030798757383 0.49559007059838 no 1649 0.493097414293208 535 2759605
SGTC_770 0389-1121 67.2 µM 0.0170681395401235 0.495662969713365 no 1650 0.49319112808626 528 6753108
SGTC_1022 4477-0945 21.3 µM 0.0158088192507128 0.496053723817682 no 1651 0.493693456286031 519 4648966
SGTC_669 0108-0021 26.2 µM 0.0152231318112503 0.4962354579054 no 1652 0.493927083641335 535 17201
SGTC_2340 7987427 183.45 µM 0.0148851770685919 0.496340322893644 no 1653 0.494061892799801 535 2239331
SGTC_1672 st016598 6.51 µM 0.0138363655727739 0.496665763328462 no 1654 0.494480264887451 536 4665860 YNL267W PIK1
SGTC_3009 9080819 71.4286 µM 0.0134817242613027 0.496775807088387 no 1655 0.494621733102789 539 17027216
SGTC_930 2810-3379 265 µM 0.0134192499318086 0.496795192644981 no 1656 0.494646654499824 533 1015764
SGTC_2652 actinonin 100 µM 0.013248776816241 0.49684808986938 no 1657 0.494714657387626 539 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1086 cerivastatin 2.18 µM 0.0131420066527344 0.496881220314029 no 1658 0.494757248811978 540 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1977 st070720 65.3 µM 0.0129190212954737 0.496950412035496 no 1659 0.494846199546732 530 682188
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.0126090257848113 0.497046602911793 no 1660 0.494969859788382 538 279621
SGTC_1482 3346-2049 8.48 µM 0.0122391883240105 0.497161362828325 no 1661 0.495117392200656 544 3826804
SGTC_2062 5245942 200 µM 0.0122151094383334 0.497168834472637 no 1662 0.495126997568174 538 1376160
SGTC_2639 lactacystin 53 µM 0.011291272101831 0.497455500622352 no 1663 0.49549552987387 537 3870 A proteasome inhibitor.
SGTC_751 0833-0568 350 µM 0.0112016373451962 0.497483314303762 no 1664 0.49553128670669 543 6954252
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.00763907709820166 0.49858878589284 no 1665 0.496952478802247 544 66535 A nucleotide analog.
SGTC_116 0155-0182 31.788 µM 0.00682843992106328 0.49884033050829 no 1666 0.497275867776277 544 771486
SGTC_2966 9084041 48.03 µM 0.0066052099069271 0.498909599940677 no 1667 0.497364921658098 538 17741380
SGTC_2735 sertaconazole 140 nM 0.00648352079378895 0.498947360718266 no 1668 0.497413467550773 543 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1157 4092-0394 27.6 µM 0.00636227289612473 0.498984984593732 no 1669 0.497461837465804 544 3659885
SGTC_3212 9128307 49.47 µM 0.00606280471400048 0.49907791122102 no 1670 0.497581305679344 537 27243542
SGTC_2700 st077718 96.8 µM 0.00556063815721345 0.499233736380773 no 1671 0.497781637765298 545 904970
SGTC_1661 st013063 9.66 µM 0.00544478188380658 0.499269687263677 no 1672 0.497827857031423 546 721395
SGTC_2834 9001755 58.44 µM 0.00538954910623766 0.499286826321445 no 1673 0.497849891398347 542 2989575
SGTC_3170 9103054 49.47 µM 0.00490190914998419 0.499438143939442 no 1674 0.49804442901703 545 16432970
SGTC_2684 capsaicin 100 µM 0.0031733385285685 0.49997453032573 no 1675 0.498734023215675 545 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3300 9124615 50.48 µM 0.00300918031504164 0.49997453032573 no 1676 0.498799512554747 543 24824903
SGTC_3188 9110789 49.47 µM 0.00281471381840002 0.499914186122781 no 1677 0.498877093133337 546 849217
SGTC_1980 st071811 45.7 µM 0.00211517163047769 0.499697113714889 no 1678 0.499156169235506 548 4974850
SGTC_1218 1348-1416 30.7 µM 0.00211183838748222 0.499696079388466 no 1679 0.499157499004098 545 6787668
SGTC_227 fluconazole 33.516 µM 0.00208526010276343 0.499687831978379 no 1680 0.499168102182265 546 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1059 3448-6867 171 µM 0.00122089794656158 0.499419615019595 no 1681 0.499512932310064 547 3934407
SGTC_3330 9141424 71.43 µM 0.000674995704340494 0.499250218282416 no 1682 0.499730715694898 548 27261020
SGTC_1518 st038567 90.8 µM 0.000452389104147819 0.499181142157438 no 1683 0.499819522865318 547 77966
SGTC_1371 2421-0008 32.7 µM -0.000262919356425484 0.498959177951159 no 1684 0.499895110353594 548 2827552
SGTC_1520 flindersine 88 µM -0.00027177308890543 0.498956430590449 no 1685 0.499891578225495 551 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_301 4119-0100 24.5 µM -0.00040245458755107 0.49891587942583 no 1686 0.499839443853419 548 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3303 9125618 40.5795 µM -0.000590190192890641 0.498857624087928 no 1687 0.499764548192247 548 22695467
SGTC_1159 4092-0538 61.2 µM -0.00267700438351344 0.498210076678348 no 1688 0.49893203104217 549 717301
SGTC_2253 7938677 135.83 µM -0.00353274958187474 0.497944536532928 no 1689 0.498590639757265 552 2301972
SGTC_487 nimodipine 119 µM -0.00399079013773316 0.497802405624966 no 1690 0.498407909307897 552 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2323 6148992 148.28 µM -0.0042139861525852 0.497733147551522 no 1691 0.49831886773021 552 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_435 c-PAF 6.7 µM -0.004613264037628 0.49760925116941 no 1692 0.498159580452768 549 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2319 6033012 152.6 µM -0.00717119465471231 0.496815528369409 no 1693 0.497139131771785 555 847246
SGTC_2419 paclitaxel 166.5 µM -0.00721522855795798 0.496801864803447 no 1694 0.497121565240483 553 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_958 1222-0007 33 µM -0.0078164679815625 0.496615302698046 no 1695 0.496881712191877 553 7312461
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.00802994322491996 0.496549062389288 no 1696 0.49679655056479 551 368090
SGTC_3140 9094243 49.47 µM -0.00808296439546219 0.496532610197837 no 1697 0.496775398864559 554 19291112
SGTC_2339 9000433 200 µM -0.00825662475731756 0.496478724338767 no 1698 0.496706120715915 552 2988954
SGTC_1277 0873-0036 22 µM -0.0106966045242681 0.495721619226931 no 1699 0.495732753573195 555 5965735
SGTC_2506 ethyl hematommate 54.16 µM -0.0125910051515137 0.4951338132002 no 1700 0.494977048410267 560 3940691 An allergen.
SGTC_3265 9137266 49.47 µM -0.0130695077355633 0.494985342159932 no 1701 0.494786169211512 555 17224265
SGTC_464 bw-b 70c 158 µM -0.0134800396020808 0.494857961805515 no 1702 0.494622405123514 567 5353454
SGTC_3226 9131256 49.47 µM -0.0140469580347159 0.494682058491271 no 1703 0.494396258815128 555 17178073
SGTC_2098 5376439 882.5 nM -0.0142818548340174 0.494609175070177 no 1704 0.494302557950664 562 2844116
SGTC_159 3970-0959 50 µM -0.015210369661904 0.494321078688624 no 1705 0.493932174412881 555 6615653
SGTC_796 1234-0020 70.7 µM -0.0154632392819747 0.494242619681034 no 1706 0.493831305893996 555 46495034
SGTC_500 h-89 112 µM -0.0168679654506049 0.493806773040054 no 1707 0.493270974498567 556 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2167 5876490 200 µM -0.01707413347853 0.493742805565124 no 1708 0.49318873719921 553 686534
SGTC_2824 7998404 51.95 µM -0.0173304487180984 0.49366327920727 no 1709 0.493086497341783 554 837851
SGTC_628 1636-0253 16 µM -0.0175959624809272 0.493580899109722 no 1710 0.492980588826423 559 4456143
SGTC_1975 st070967 30.8 µM -0.0179848509669974 0.493460240430418 no 1711 0.492825469317439 558 261391
SGTC_1024 4507-0395 26 µM -0.0181628106010053 0.493405025895055 no 1712 0.492754485290209 553 4201836
SGTC_2016 5121758 140 µM -0.018763750439055 0.493218576609196 no 1713 0.492514785843821 561 2795203
SGTC_2730 imipramine 71.33 µM -0.0189880373775131 0.493148989089753 no 1714 0.492425324240292 563 3696 A tricyclic antidepressant.
SGTC_725 1497-0963 19 µM -0.0223387847406266 0.492109408414401 no 1715 0.491088855422172 556 3549977
SGTC_2808 7946468 45.46 µM -0.0234121380628856 0.491776407919497 no 1716 0.490660761443262 566 2970879
SGTC_1986 st071812 45 µM -0.0237317304683718 0.491677257667911 no 1717 0.490533297937342 556 11838594
SGTC_2450 5739737 12.93 µM -0.0259427683393079 0.49099132036103 no 1718 0.489651493656234 553 2262825
SGTC_877 0771-0151 33.1 µM -0.0275700350231198 0.490486505149468 no 1719 0.489002540582114 556 6166523
SGTC_569 4130-2812 160 µM -0.0278243623311575 0.490407608378642 no 1720 0.488901117576171 563 743552
SGTC_2872 9044037 25.97 µM -0.0286937576687564 0.490137909620728 no 1721 0.488554417489094 558 6465195
SGTC_2607 solasodine 47.35 µM -0.0335042545219721 0.488645710168325 no 1722 0.486636236560141 573 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2759 disulfiram 3.38 µM -0.0339456618023444 0.488508794803471 no 1723 0.486460240649497 565 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2569 tetrandrine 100 µM -0.0341727963922187 0.488438342900788 no 1724 0.486369679600501 574 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2462 5162487 171.77 µM -0.0348654946256927 0.48822348614807 no 1725 0.486093497587449 563 2259986
SGTC_687 k029-0044 34.9 µM -0.0368475429953406 0.48760872602707 no 1726 0.485303282969067 563 5829338
SGTC_984 1492-0255 2.91 µM -0.0387781205320625 0.487009958600165 no 1727 0.484533644498722 566 1585198
SGTC_2270 7924575 90.91 µM -0.0395645262439231 0.486766063672574 no 1728 0.484220154619337 595 1262135
SGTC_2352 9027995 87.8 µM -0.0411263368467218 0.486281700364346 no 1729 0.483597589296922 575 2997347
SGTC_1830 st055982 50.3 µM -0.0418072310950592 0.486070541365666 no 1730 0.483326185237201 569 455313 An antimicrobial agent.
SGTC_535 2293-4129 48.2 µM -0.0419591504404426 0.486023428652494 no 1731 0.483265631322363 601 396118 YIL048W NEO1
SGTC_1295 1013-0063 9.78 µM -0.0420558151339429 0.48599345142645 no 1732 0.483227101699358 573 6826038
SGTC_251 melphalan 456.522 µM -0.0424288090274965 0.485877780957843 no 1733 0.483078431369569 577 460612 A DNA alkylator.
SGTC_44 0929-0055 61.211 µM -0.0429873897891971 0.485704559707748 no 1734 0.482855793026353 567 1379590
SGTC_2457 5731572 11.68 µM -0.0443554970333265 0.485280307993985 no 1735 0.482310517466435 565 2865357
SGTC_2122 5258151 111.688 µM -0.0450699748462337 0.485058754150833 no 1736 0.482025766847633 578 2173356
SGTC_1108 betulinic acid 729.144 nM -0.0456445773779524 0.484880577854308 no 1737 0.481796769283985 567 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_217 ketoconazole 989 nM -0.0469261626129468 0.484483186928766 no 1738 0.481286038154542 564 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_146 3448-8650 53.125 µM -0.0480932317828547 0.484121318271471 no 1739 0.480820970110295 582 2891488 YIL048W NEO1
SGTC_3326 9140064 16.379 µM -0.0486032660806407 0.483963177983699 no 1740 0.480617733543663 572 1868434
SGTC_3262 9137218 49.47 µM -0.0486395183633036 0.483951937763949 no 1741 0.480603288060293 564 17650664
SGTC_821 1114-0266 29.2 µM -0.0490513447429508 0.483824249625996 no 1742 0.480439188983276 580 3123235
SGTC_335 4077-0256 27.6 µM -0.0507628658441879 0.483293604739758 no 1743 0.479757240735151 574 3121989
SGTC_2005 4024620 188 µM -0.0513017264769194 0.483126540931921 no 1744 0.479542546194187 571 236743
SGTC_1286 0929-0070 131 µM -0.0531000339065336 0.482569030462091 no 1745 0.478826102219553 576 1420408
SGTC_169 k015-0017 16.025 µM -0.0532560679329333 0.482520658453898 no 1746 0.478763941603632 581 1840002
SGTC_2418 pentamidine 31.67 µM -0.0557940658062952 0.481733892003598 no 1747 0.477752931191212 582 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3 0833-0587 95.581 µM -0.0575671394293336 0.481184290210576 no 1748 0.477046712591677 554 5382644
SGTC_2767 sibutramine 71.45 µM -0.0578814755056684 0.481086858775757 no 1749 0.476921519392792 597 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2813 7971799 71.43 µM -0.0596037761995969 0.480553035621305 no 1750 0.476235605372973 589 2234054
SGTC_2741 miltefosine 3.04 µM -0.0600669390697501 0.480409485261015 no 1751 0.47605116059976 570 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_42 0133-0086 60.653 µM -0.0601207610660724 0.480392804107769 no 1752 0.476029727465201 579 162923 Model of phenazepam hydroxylation.
SGTC_1382 3002-2117 298 µM -0.0606136710489996 0.480240037184121 no 1753 0.475833442810943 583 1497314
SGTC_98 0074-0023 107.663 µM -0.0611899516373315 0.480061435003247 no 1754 0.475603966085009 611 3563821
SGTC_2388 9080168 200 µM -0.061237371511661 0.480046738706496 no 1755 0.475585083702575 582 15943073
SGTC_122 0236-0016 402.397 µM -0.0621879138061498 0.479752153803466 no 1756 0.475206593623189 575 6808838
SGTC_2185 6113692 200 µM -0.0627624126802941 0.479574114794271 no 1757 0.474977848583922 589 874150
SGTC_899 1083-0020 478 µM -0.0636702592589131 0.479292778604267 no 1758 0.474616393177086 584 767123
SGTC_2537 larixol 68.93 µM -0.0641428000426603 0.479146345133238 no 1759 0.474428261243089 572 6708759
SGTC_1221 2958-7315 257 µM -0.0642356516707835 0.479117572103252 no 1760 0.474391295036469 582 4562705
SGTC_190 3970-0790 3.722 µM -0.0648835397399928 0.478916806417029 no 1761 0.474133363180106 572 2832352
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.0656009895285198 0.478694491389563 no 1762 0.473847750641287 590 16486 A toxic proline analog.
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.0679608915153135 0.477963279438094 no 1763 0.472908383161513 575 2724 A muscle relaxant with antifungal properties.
SGTC_1796 st049173 110.4 µM -0.068122102041231 0.477913331286719 no 1764 0.472844218169369 573 94134
SGTC_1811 st050069 61.5 µM -0.0684559358310329 0.477809900058474 no 1765 0.472711347930959 583 3877702
SGTC_1696 st025591 34.7925 µM -0.0685081709264549 0.477793716271341 no 1766 0.472690557950417 581 2787147
SGTC_2888 9058547 12.99 µM -0.068633705947007 0.477754822416379 no 1767 0.47264059432509 586 16476514
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.0686716249420475 0.47774307421529 no 1768 0.472625502442123 571 688664
SGTC_2313 7726885 200 µM -0.0694852601143924 0.477490995480883 no 1769 0.472301682509417 578 726423
SGTC_1181 1222-0449 220 µM -0.0702834965249715 0.477243696309392 no 1770 0.471984008943065 588 658318
SGTC_2588 indole-3-carbinol 100 µM -0.070327723606936 0.47722999470826 no 1771 0.471966408442499 579 3712 Induces cell cycle arrest.
SGTC_2529 gangaleoidin 93.61 µM -0.0712657785053882 0.476939390581654 no 1772 0.471593115375047 568 4565183
SGTC_775 4577-0580 57.3 µM -0.0714579359666745 0.476879862790222 no 1773 0.471516650586479 626 2006902
SGTC_760 0568-0725 82.9 µM -0.0741631807004708 0.476041869806988 no 1774 0.470440271341731 573 3916171
SGTC_117 lucigenin 22.078 µM -0.0745801789907849 0.475912707224412 no 1775 0.470274372534409 615 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_415 dibenzyl ketone 100 µM -0.0747710884488535 0.475853575071224 no 1776 0.470198422740595 586 7593
SGTC_165 k038-0023 64.381 µM -0.0781119214054987 0.474818875197699 no 1777 0.468869512130104 585 46368543
SGTC_2018 5133068 143 µM -0.0794203882234773 0.474413671721549 no 1778 0.468349126202302 590 785362
SGTC_1926 methyl fluorone black 53.6 µM -0.0796687946775661 0.474336748667263 no 1779 0.468250339389163 574 72721 Reacts with homocysteine.
SGTC_1958 st076513 41.9 µM -0.0810445732680305 0.473910734097938 no 1780 0.467703252362669 605 732122 YGL099W LSG1
SGTC_748 act1.228 77.9 µM -0.0829672214827825 0.473315429555678 no 1781 0.466938801596379 595 4421505 YNR035C ARC35
SGTC_4 0960-0234 25.671 µM -0.0830636992628 0.473285558951843 no 1782 0.46690044492757 575 6821112
SGTC_2673 kobusone 100 µM -0.0831143133426022 0.473269888324563 no 1783 0.466880322411919 582 6710676 An epoxy ketone and protein crosslinker.
SGTC_2037 5169046 200 µM -0.0834802568553204 0.473156589771142 no 1784 0.466734837668185 589 5718022
SGTC_817 1391-0715 46 µM -0.0838532301894681 0.473041116972685 no 1785 0.466586562717383 582 1353946
SGTC_1418 3966-3099 2.4 µM -0.0846778261667306 0.472785829551025 no 1786 0.466258762397913 577 740335
SGTC_797 k781-0471 270 µM -0.085084625730789 0.47265989221344 no 1787 0.466097056435173 589 23738129
SGTC_807 1315-0151 48 µM -0.0884487533134629 0.471618528799003 no 1788 0.464760006779757 621 4011080
SGTC_1316 1272-0050 65.9 µM -0.0891044639829626 0.471415576375627 no 1789 0.464499444881833 584 7340392
SGTC_2054 5233173 129 µM -0.0893240130780074 0.471347624248266 no 1790 0.464412205334744 588 6889
SGTC_1031 k035-0009 16 µM -0.08937024152643 0.471333316295465 no 1791 0.46439383631773 616 5180959
SGTC_393 acivicin 6.25 µM -0.0906391461417764 0.470940598019104 no 1792 0.463889662907166 603 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.0965686188433882 0.469105842923037 no 1793 0.461534489260971 592 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2012 4023501 200 µM -0.097035487843642 0.468961407124122 no 1794 0.461349106096224 596 3477460
SGTC_726 3448-4391 34.2 µM -0.0972756185264097 0.468887119208579 no 1795 0.461253758878659 595 1356692
SGTC_1305 1181-0477 144 µM -0.097954487968818 0.468677106951756 no 1796 0.460984216418833 585 6252086
SGTC_1369 1866-0067 208 µM -0.0991254200846834 0.468314892725605 no 1797 0.460519344585763 604 3531355
SGTC_3058 9093861 49.47 µM -0.0991936075643313 0.468293800527399 no 1798 0.460492275126521 596 17217477
SGTC_1792 st045773 43.6 µM -0.0992515125925656 0.468275889034351 no 1799 0.460469287797944 607 2919270
SGTC_2938 9059746 27.26 µM -0.0997102183022355 0.468134002003061 no 1800 0.46028719397119 616 6471769
SGTC_2783 7738165 71.43 µM -0.101403631434479 0.467610229979584 no 1801 0.459615026933865 598 17201110
SGTC_1308 1187-1617 41.4 µM -0.104718482240874 0.466585111053337 no 1802 0.458299597944465 594 2882570
SGTC_701 4424-0219 185 µM -0.105987696157164 0.466192664450972 no 1803 0.457796057121133 615 2911779
SGTC_80 0159-0065 512.242 µM -0.107703984140194 0.465662032901172 no 1804 0.457115254507082 598 1548079
SGTC_447 ml7 120 µM -0.109144831203173 0.465216607606989 no 1805 0.4565438085514 592 4216 Selective myosin light chain kinase inhibitor.
SGTC_3240 9133527 49.47 µM -0.110009092326873 0.464949449697241 no 1806 0.456201082024866 638 17617455
SGTC_1540 guanosine 70.6 µM -0.110066450256036 0.464931719937083 no 1807 0.456178337637534 592 6802 Guanosine is a purine nucleoside
SGTC_11 0438-0307 1.3 µM -0.11116700787113 0.464591542962813 no 1808 0.455741956670369 602 4011476
SGTC_75 0159-0059 199.013 µM -0.111534967065559 0.464477814336465 no 1809 0.45559606943142 585 5377270
SGTC_761 k216-0224 480 µM -0.112444379396676 0.46419674614021 no 1810 0.455235534377038 601 1340404
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.11287695770591 0.464063057266293 no 1811 0.455064052323373 602 688788
SGTC_358 0075-0058 9.45 µM -0.114251872799683 0.463638165031982 no 1812 0.454519066267354 671 1069125
SGTC_112 phenothiazine 287.218 µM -0.115904089130594 0.463127632852547 no 1813 0.453864277441662 606 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_863 0466-0191 129 µM -0.115907644980817 0.463126534165752 no 1814 0.453862868359449 616 765160 YPR165W RHO1
SGTC_994 3910-0338 138 µM -0.116282864758549 0.463010600320845 no 1815 0.45371418271103 602 3479481
SGTC_3062 9077494 49.47 µM -0.117565667947486 0.462614268922091 no 1816 0.453205904625191 592 16459633
SGTC_1146 3579-1023 7 µM -0.117599886879844 0.462603697239879 no 1817 0.453192347290851 604 X1146
SGTC_1234 0326-0494 15.5 µM -0.11865052519912 0.462279123311968 no 1818 0.452776117362125 610 1547813
SGTC_3070 9117005 49.47 µM -0.11872379210414 0.462256489885153 no 1819 0.452747093243755 594 8779016
SGTC_114 0364-0001 490.298 µM -0.118968473707948 0.462180904349544 no 1820 0.452650166347089 607 4003655
SGTC_69 0096-0274 206.684 µM -0.121027043449229 0.461545037997103 no 1821 0.451834807530561 617 6741392
SGTC_2906 7926292 26.41 µM -0.121287473004925 0.461464601546596 no 1822 0.451731670930019 632 2966319
SGTC_950 1165-0508 94.1 µM -0.122244165963206 0.461169130262267 no 1823 0.451352824670886 608 6148369
SGTC_1686 st019653 115.5 µM -0.122610049754673 0.461056133986489 no 1824 0.451207947970826 603 97252
SGTC_60 0986-0278 202 µM -0.122744691942512 0.461014553089056 no 1825 0.451154636186731 602 3110598
SGTC_1733 st037357 54.9 µM -0.124116947642702 0.460590790367985 no 1826 0.45061133981941 618 1272339 YGL099W LSG1
SGTC_3209 9113616 49.47 µM -0.125055637111683 0.460300941856887 no 1827 0.450239751980883 609 16649353
SGTC_3019 9081971 49.47 µM -0.125545587090039 0.460149663483095 no 1828 0.450045818612881 612 16451803
SGTC_2889 9059656 51.95 µM -0.126142602448979 0.459965335091337 no 1829 0.44980952245513 604 3949838
SGTC_664 1222-0054 14.9 µM -0.127100950745928 0.45966946322346 no 1830 0.449430249489934 595 6813991
SGTC_1001 4048-4355 44.4 µM -0.127252583813878 0.459622651430673 no 1831 0.449370243878814 635 21824233
SGTC_962 1254-0300 21.5 µM -0.127760036192476 0.459465996038552 no 1832 0.449169438655915 607 7340576
SGTC_3142 9086498 49.47 µM -0.130521480340799 0.458613622806155 no 1833 0.448076930327009 643 25236367
SGTC_2568 diosmetin 100 µM -0.131820490515146 0.458212723711147 no 1834 0.447563139447702 594 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_808 0711-0032 135 µM -0.132227353468997 0.458087166834887 no 1835 0.44740223306724 608 4252555
SGTC_1510 1123-0200 71.5 µM -0.132960088664106 0.457861057167423 no 1836 0.447112472407144 651 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_966 1300-0360 30.2 µM -0.134364563821763 0.457427698110079 no 1837 0.446557150734578 618 70588
SGTC_2544 sphondin 68.51 µM -0.134504849149967 0.457384415020045 no 1838 0.446501688433615 599 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_869 0564-0080 44.1 µM -0.135787935856426 0.456988559951648 no 1839 0.445994464256851 602 6843321
SGTC_337 1315-0038 354 µM -0.135823459202823 0.456977600972805 no 1840 0.445980422577571 611 1626437
SGTC_2273 7815444 169.05 µM -0.136650949129362 0.456722328989007 no 1841 0.445653351311991 627 2824616
SGTC_2480 5767542 37.17 µM -0.137019233181543 0.456608722948979 no 1842 0.445507796306248 608 2867358
SGTC_1705 st027868 56.3335 µM -0.139088699893067 0.455970412577959 no 1843 0.444690028804347 622 292948
SGTC_590 k048-0076 22.4 µM -0.140858108414628 0.455424742783361 no 1844 0.4439910183746 625 6832814
SGTC_2072 5231554 129 µM -0.143073819951935 0.454741555810381 no 1845 0.443115940426821 613 789545
SGTC_377 3970-0964 33.1 µM -0.144456661138462 0.454315241714143 no 1846 0.442569938415732 601 16481235
SGTC_2968 9090663 33.37 µM -0.144652291737145 0.454254935279254 no 1847 0.442492704271098 666 25236811
SGTC_341 1486-1430 230 µM -0.146010475680675 0.453836281298665 no 1848 0.441956559330142 618 2054753 YPL210C SRP72
SGTC_2601 securinine 100 µM -0.147010937845017 0.453527926197958 no 1849 0.441561693487257 599 442872 A GABA receptor antagonist.
SGTC_2106 5357045 167.29 µM -0.147409463781882 0.45340510325251 no 1850 0.441404418053869 617 668842
SGTC_792 4534-1957 155 µM -0.147655226000708 0.453329363252413 no 1851 0.441307434341927 607 1717904
SGTC_3215 9129942 49.47 µM -0.149664588181764 0.452710173769805 no 1852 0.44051462398542 616 17682944
SGTC_2518 prenyletin 46.28 µM -0.15027532060993 0.452521997911299 no 1853 0.440273701583766 594 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2484 5809818 12.04 µM -0.150379298526396 0.452489961810484 no 1854 0.44023268646081 620 2870548
SGTC_137 0438-0332 85.389 µM -0.150380052426869 0.452489729531218 no 1855 0.440232389079614 643 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3055 9094636 49.47 µM -0.151265563392328 0.452216911877325 no 1856 0.439883116546138 620 25236176
SGTC_1115 galangin 695.678 nM -0.15180928566994 0.452049407295091 no 1857 0.439668679059856 648 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_543 3844-1095 191 µM -0.15258995362501 0.451808921763965 no 1858 0.43936082403127 612 4230703
SGTC_1205 4161-2785 76 µM -0.153159711502816 0.451633418446372 no 1859 0.439136164156414 666 3498106
SGTC_3124 9127567 49.47 µM -0.15576264299727 0.450831754558055 no 1860 0.438110058858185 641 17592030
SGTC_1034 k072-0165 12.7 µM -0.156803864383456 0.450511129944716 no 1861 0.437699713596138 668 5835461
SGTC_3310 9130229 44.1445 µM -0.158374201357216 0.450027635247044 no 1862 0.437080970767807 633 7761258
SGTC_453 enantio-paf c16 10 µM -0.159582881462548 0.449655542395566 no 1863 0.436604832381116 647 13871343 A lipid and platelet activating factor
SGTC_719 2810-4230 27.3 µM -0.160147268138007 0.449481810778657 no 1864 0.436382533531918 610 721079
SGTC_373 0844-0104 25.9 µM -0.160274032818742 0.449442790931166 no 1865 0.436332606618721 625 5375804
SGTC_2346 9031566 143.75 µM -0.161459312113865 0.449077969973781 no 1866 0.435865827538319 638 4771086
SGTC_1422 4031-0024 15.5 µM -0.163230571981117 0.448532868478558 no 1867 0.435168448022786 629 782427
SGTC_204 PMA1.184 62.41 µM -0.163563565002307 0.448430401395078 no 1868 0.435037364631723 623 2252213 YGL008C PMA1
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.163801489477834 0.448357190474741 no 1869 0.434943709542237 631 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.163876091199369 0.448334235398202 no 1870 0.434914344542624 606 97141
SGTC_2286 7945697 125 µM -0.164447357842887 0.448158461420646 no 1871 0.434689492410701 631 1245733
SGTC_1402 3909-7673 35.9 µM -0.164579540690928 0.448117791310421 no 1872 0.434637467882419 619 5328014
SGTC_702 1488-0190 94 µM -0.165189058931529 0.447930261377707 no 1873 0.434397588335096 605 949357
SGTC_3065 9113888 49.47 µM -0.165314878561078 0.447891552012298 no 1874 0.434348074272136 654 16648368
SGTC_963 1269-2853 151 µM -0.167176409485155 0.447318896052186 no 1875 0.433615622846956 604 3668223
SGTC_442 cape 100 µM -0.167800829177659 0.447126832637134 no 1876 0.433369985080018 626 5281787
SGTC_626 0214-0009 33 µM -0.16794527593494 0.44708240444856 no 1877 0.433313165455792 646 3437874
SGTC_1387 3342-1166 1.8 µM -0.168595018790918 0.446882568111827 no 1878 0.433057599452323 619 3418228
SGTC_2877 9040724 71.43 µM -0.168896054742523 0.446789985403532 no 1879 0.432939201238876 631 6463895
SGTC_1834 st055981 52.8 µM -0.16894476242711 0.446775005772974 no 1880 0.432920044946859 654 471719 YDL150W RPC53
SGTC_2221 6807166 181.081 µM -0.170210477536397 0.446385772637794 no 1881 0.432422306036784 616 674925
SGTC_704 1310-0270 142 µM -0.171814435416269 0.445892597219814 no 1882 0.431791708234963 642 5718033
SGTC_3151 9099821 49.47 µM -0.174214564259653 0.445154776458562 no 1883 0.430848419970146 665 17174189
SGTC_2850 9015429 58.44 µM -0.17531880510429 0.444815386732923 no 1884 0.430414568135962 608 6457570
SGTC_1414 3917-0015 5.4 µM -0.176289880125397 0.444516959098958 no 1885 0.430033106008809 622 6618702
SGTC_1602 st001878 87.6 µM -0.17663428379829 0.44441112562256 no 1886 0.429897831452185 667 595405 YLR310C CDC25
SGTC_1722 st034304 3.6505 µM -0.177115814519294 0.444263160356016 no 1887 0.429708710059571 637 4036148 YLR033W RSC58
SGTC_3187 9109394 49.47 µM -0.177951906301739 0.444006263658598 no 1888 0.429380373001289 627 17098090
SGTC_2162 5663267 200 µM -0.178175224743112 0.443937651041532 no 1889 0.429292683087104 668 6456493
SGTC_348 k064-0012 10.7 µM -0.178428956650122 0.443859696195316 no 1890 0.429193055025112 618 5066323
SGTC_365 0121-0052 13.6 µM -0.178513543270716 0.443833708866329 no 1891 0.429159843014429 624 3101739
SGTC_281 1672-3440 14.9 µM -0.17867901154729 0.443782873173507 no 1892 0.42909487515712 624 6833000
SGTC_526 4469-0568 170 µM -0.178754291195793 0.443759745825381 no 1893 0.429065318722555 630 2901964
SGTC_1600 coumarin 106 71.1 µM -0.17927500012196 0.443599779330874 no 1894 0.428860887921549 666 100336 A hepatotoxic, DNA x-linker.
SGTC_2205 7238770 200 µM -0.179575270436098 0.443507537749037 no 1895 0.428743010192864 644 279867
SGTC_1097 itavastatin 7.23 µM -0.17985307918582 0.443422198976594 no 1896 0.428633955906567 621 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1438 4092-1045 4 µM -0.180960983686231 0.443081893104527 no 1897 0.428199100428547 628 1351342
SGTC_501 nsc-95397 161 µM -0.18104874024579 0.443054939438233 no 1898 0.428164659463551 631 262093
SGTC_1571 st070080 73.4 µM -0.181799606567203 0.442824328144565 no 1899 0.427869996645236 634 4315245
SGTC_3284 9108171 64.8615 µM -0.182845779918544 0.442503052409143 no 1900 0.42745951344652 620 8687505
SGTC_2116 5511452 16.8835 µM -0.183664765771417 0.442251571437314 no 1901 0.427138225740445 657 870744
SGTC_1679 SEC14.276 6.7 µM -0.185573557795051 0.441665540848269 no 1902 0.426389595586349 630 1005053 YMR079W SEC14
SGTC_136 0097-0015 404.482 µM -0.185671931073331 0.441635342080172 no 1903 0.426351020649168 632 4861337
SGTC_579 4491-1009 110 µM -0.185733759101359 0.441616362198297 no 1904 0.426326776495974 632 1271041
SGTC_318 1488-0629 67.2 µM -0.186172969238054 0.441481537943868 no 1905 0.42615456039279 644 3662576
SGTC_2625 euphol 100 µM -0.186216241017428 0.441468255180425 no 1906 0.426137594111392 614 6708538 A triterpene alcohol.
SGTC_2417 cerulenin 830 nM -0.19030762251402 0.440212658666592 no 1907 0.42453404045151 657 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_648 0375-0473 33.3 µM -0.190536848889812 0.440142329469171 no 1908 0.424444235401798 645 1713139
SGTC_2541 muurolladie-3-one 83.07 µM -0.190577167324699 0.440129959520889 no 1909 0.424428440072445 652 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1560 lithocholic acid 53.1 µM -0.190780021284413 0.440067723542743 no 1910 0.424348970945029 618 9903 A bile acid which acts as a detergent.
SGTC_1758 st042942 75.2445 µM -0.190941571292007 0.440018160754305 no 1911 0.42428568506226 631 669317
SGTC_884 0851-0618 334 µM -0.191755049528721 0.439768603725936 no 1912 0.42396704137014 668 9642473
SGTC_2394 5221648 200 µM -0.191804050650495 0.439753572034914 no 1913 0.423947848958765 640 788586
SGTC_1728 st035614 33.7865 µM -0.191916798820411 0.439718985490186 no 1914 0.423903689241391 645 15945546
SGTC_48 0382-0018 55 µM -0.195100542989759 0.438742533390248 no 1915 0.422657118750622 632 762596
SGTC_1988 st071872 53.4 µM -0.1965419754829 0.438300569272555 no 1916 0.422092990801587 625 16414116
SGTC_629 3448-6466 76.7 µM -0.196937581441058 0.438179284178092 no 1917 0.421938191902233 659 573744
SGTC_2074 5212007 75.395 µM -0.197095203304797 0.43813096199653 no 1918 0.421876518507547 613 758611
SGTC_3043 9092303 49.47 µM -0.197573166763475 0.437984438239796 no 1919 0.421689515378302 639 25236084
SGTC_386 1509-0011 3.07 µM -0.197921319000258 0.437877714566217 no 1920 0.421553311983021 650 3107280
SGTC_87 0100-0052 35.5 µM -0.198097923169947 0.437823579499622 no 1921 0.421484224853179 632 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_547 1120-0019 610 nM -0.198777990513907 0.43761512706042 no 1922 0.421218206722893 643 3676939
SGTC_1025 k007-0731 70 µM -0.200490688398243 0.437090232277603 no 1923 0.420548419870472 610 6256118
SGTC_2703 st077852 53.4 µM -0.201028164227435 0.436925533503832 no 1924 0.420338275857515 668 6281836
SGTC_225 nsc-122657 1.016 µM -0.202054578743722 0.436611039592579 no 1925 0.419937028167046 669 275685
SGTC_1939 st074455 53.6 µM -0.20271558674295 0.436408527612468 no 1926 0.419678669828606 648 1644229
SGTC_1224 0823-0416 294 µM -0.203195529575519 0.436261498723602 no 1927 0.419491103417307 654 3598164
SGTC_413 propylparaben 100 µM -0.203702974817219 0.436106054141792 no 1928 0.419292808686298 641 7175 A pharmaceutical preservative.
SGTC_404 fumagillin 50 µM -0.204431639736401 0.435882861089507 no 1929 0.419008103646998 637 12015870 A methionine aminopeptidase binder.
SGTC_2936 9038235 15.59 µM -0.205042013988481 0.435695916665839 no 1930 0.418769649946207 625 4749415
SGTC_370 0180-0345 38.7 µM -0.205521709818781 0.435549006295633 no 1931 0.418582269063301 636 3989527
SGTC_1245 0418-0076 17.2 µM -0.206248248458798 0.435326515446007 no 1932 0.418298500552904 688 6790114
SGTC_2193 5925765 200 µM -0.20624903787382 0.435326273711391 no 1933 0.41829819224949 642 877370
SGTC_2987 9018338 71.43 µM -0.206285306446229 0.435315167577629 no 1934 0.418284027733178 649 5055682
SGTC_552 k242-0005 476 µM -0.206592171258375 0.435221201718892 no 1935 0.418164187401687 659 4088318
SGTC_384 k007-0144 5.16 µM -0.207492966539591 0.434945388041138 no 1936 0.417812442521474 638 6824886
SGTC_1262 0737-0114 49.6 µM -0.20879806970978 0.434545835888427 no 1937 0.417302939137299 657 765919
SGTC_1529 apigenin 74 µM -0.210407384285297 0.434053242694074 no 1938 0.416674864913731 684 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1063 disulfiram 1.84 µM -0.212843583884329 0.433307744297573 no 1939 0.415724483758181 624 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3328 9140624 29.0385 µM -0.214875972123236 0.432685997109075 no 1940 0.414932009397213 645 4904392
SGTC_2242 6630449 61.2675 µM -0.215533550852572 0.432484866557054 no 1941 0.414675678442281 654 691249 YDR170C SEC7
SGTC_46 0329-0187a 2.197 µM -0.21599510377289 0.432343703954107 no 1942 0.414495782055982 653 46494817
SGTC_1054 3429-0080 167 µM -0.216526149158773 0.432181298271284 no 1943 0.414288822246696 682 1162877
SGTC_3023 9089636 49.47 µM -0.216945772052908 0.432052976208483 no 1944 0.414125303006846 620 17249241
SGTC_2136 5328288 199.296 µM -0.21968582312892 0.431215236389076 no 1945 0.413057923232468 643 262395
SGTC_35 0133-0054 64.071 µM -0.22141505464597 0.430686702262408 no 1946 0.412384635699399 660 99677
SGTC_595 3909-8003 73.7 µM -0.222158178238577 0.430459606972967 no 1947 0.412095374765315 675 699517
SGTC_2020 4017018 200 µM -0.226122692311403 0.42924845937759 no 1948 0.410552997861034 674 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.226230634813416 0.429215492513656 no 1949 0.410511022524461 641 94937 An inhibitor of serotonin biosynthesis.
SGTC_2360 9040895 200 µM -0.226808782580037 0.429038928040288 no 1950 0.410286217076605 658 4914414
SGTC_279 1273-0055 2.93 µM -0.22714798827214 0.428935342316513 no 1951 0.410154334948696 650 2847562
SGTC_2476 5806916 10.51 µM -0.227151711006347 0.428934205505072 no 1952 0.410152887617451 653 2870194
SGTC_1574 spiramycin 23.7 µM -0.229952051497861 0.428079233121617 no 1953 0.409064514324415 637 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1088 bifonazole 369 nM -0.232635907494324 0.427260141320801 no 1954 0.408022071013355 655 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_3248 9135562 49.47 µM -0.235192200704216 0.426480272095553 no 1955 0.407029779587368 650 17650701
SGTC_420 mitomycin C 81.9 mM -0.235238398590695 0.426466180763881 no 1956 0.407011852149196 642 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_858 0438-0351 2.77 µM -0.235703926433268 0.426324190175579 no 1957 0.406831211439136 658 2799119
SGTC_1320 1313-0481 95.3 µM -0.236360571497318 0.426123923186733 no 1958 0.406576444420863 646 6813365 YLR208W SEC13
SGTC_1965 Pectolinarigenin 58.4 µM -0.236394003827416 0.426113727331976 no 1959 0.406563474307295 646 5320438 An anti-inflammatory.
SGTC_676 falcarinol 140 µM -0.236494508611535 0.426083076694277 no 1960 0.406524483970038 676 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3175 9106517 49.47 µM -0.236678028732267 0.426027110274587 no 1961 0.406453290632122 666 41468073
SGTC_1085 doxorubicin 7.67 µM -0.237570903677517 0.425754839807967 no 1962 0.406106959979767 664 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1409 3909-8004 61.9 µM -0.237779569429533 0.425691215030105 no 1963 0.406026032745773 636 2119279
SGTC_2104 5389443 200 µM -0.237833438670208 0.425674789944109 no 1964 0.406005141188042 671 2244536
SGTC_2103 5378138 10 µM -0.238617678785772 0.425435684591885 no 1965 0.405701027690922 654 244142
SGTC_565 1418-0001 44.5 µM -0.240029781434954 0.425005220720035 no 1966 0.40515358456445 691 2862145
SGTC_982 1491-0518 27.5 µM -0.240236105227523 0.424942332667815 no 1967 0.405073612586854 638 3091256
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.240993083371926 0.424711620045715 no 1968 0.404780238619436 667 551469
SGTC_1857 st056007 79.3 µM -0.241116699252704 0.424673946710634 no 1969 0.404732335206272 654 619834
SGTC_2385 9074692 200 µM -0.241239773428088 0.424636439149929 no 1970 0.404684643132258 634 17046906
SGTC_2999 9069765 71.4286 µM -0.242024675699003 0.424397251748594 no 1971 0.404380521541501 661 2097066
SGTC_2395 5646831 180.19 µM -0.242183504786338 0.424348854308552 no 1972 0.4043189879658 685 6808628
SGTC_1391 3442-0225 151 µM -0.244708782843464 0.42357952055135 no 1973 0.4033409635237 639 5227075
SGTC_1359 1582-0056 520 nM -0.244975385995243 0.423498316023161 no 1974 0.40323774494421 668 3661189
SGTC_2801 7907800 81.82 µM -0.245210318083838 0.423426760862134 no 1975 0.403146793780562 678 6620925
SGTC_257 daunorubicin 18.5 µM -0.246031071290931 0.423176797275283 no 1976 0.402829090095155 648 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2269 7935389 174.42 µM -0.24620880823501 0.423122670866025 no 1977 0.40276029870678 632 97605
SGTC_472 calcifediol 10 µM -0.246731075136528 0.422963632804134 no 1978 0.402558177711859 632 5283731 A vitamin D metabolite.
SGTC_1297 1068-0111 14.1 µM -0.247070100407887 0.42286040126986 no 1979 0.402426986464306 649 767057
SGTC_2740 felodipine 17.08 µM -0.247712792197521 0.42266471931224 no 1980 0.402178316775638 651 3333 L-type calcium channel blocker
SGTC_2452 5863136 48.41 µM -0.248078381582467 0.4225534159203 no 1981 0.402036880940104 648 2184096
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.250762464238824 0.42173643903465 no 1982 0.400998881831269 672 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1421 4029-0249 71.4 µM -0.251977684059086 0.421366662853038 no 1983 0.40052915645717 681 2894095
SGTC_728 3030-5151 22.5 µM -0.253147057961846 0.421010902470183 no 1984 0.400077287917296 649 3125388
SGTC_983 1491-0821 12.2 µM -0.254226355389256 0.420682603410436 no 1985 0.399660345332047 647 46495113
SGTC_2563 tomatine 8.54 µM -0.25785712848905 0.419578606495686 no 1986 0.398258586344762 725 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2466 5983409 37.09 µM -0.258451659367175 0.419397889553755 no 1987 0.398029176008399 679 2879657
SGTC_1747 st037496 66.6 µM -0.258921210932857 0.419255174038488 no 1988 0.397848016075909 643 723305
SGTC_3195 9113082 49.47 µM -0.261151126387801 0.418577558795283 no 1989 0.396987983024599 644 17018038
SGTC_2073 5212005 126 µM -0.264247288708281 0.417637113808834 no 1990 0.395794687245095 685 691789
SGTC_2514 salinomycin 42.74 µM -0.26630957823182 0.417010963834985 no 1991 0.395000398509306 688 23682228 A polyether potassium ionophore.
SGTC_2977 9011197 71.43 µM -0.266388026600213 0.416987149576466 no 1992 0.394970192789464 660 2704722
SGTC_155 k072-0202 43.6 µM -0.268289913945063 0.416409894619726 no 1993 0.394238084619768 639 5857737
SGTC_1480 1070-0044 41.2 µM -0.26847147741682 0.416354796442113 no 1994 0.394168213481348 656 3124987
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.26943993489116 0.416060931185288 no 1995 0.39379557921565 691 688751
SGTC_2951 9072950 58.06 µM -0.269833809353368 0.415941428746591 no 1996 0.393644055572361 659 16488155
SGTC_1490 4089-0339 670 nM -0.271367998214949 0.415476026427709 no 1997 0.393054006301849 677 742542
SGTC_3256 9138902 49.47 µM -0.273206794225236 0.414918376558179 no 1998 0.392347128777869 673 17228773
SGTC_1207 2099-0101 141 µM -0.274412829865805 0.414552716306622 no 1999 0.391883692250449 704 5837381
SGTC_663 1486-0733 13.9 µM -0.274798433384737 0.414435820043092 no 2000 0.391735550880062 680 722445 YPR165W RHO1
SGTC_467 ro 31-8220 72.8 µM -0.274807512000886 0.414433067938768 no 2001 0.391732063241406 669 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_898 1000-0849 28.3 µM -0.276526781696738 0.413911962005292 no 2002 0.391071746223887 675 6751807
SGTC_1487 3970-0795 2.82 µM -0.27655812165677 0.413902464352973 no 2003 0.391059712445457 667 3765103
SGTC_1279 0874-0590 65.2 µM -0.277061354018402 0.413749965442777 no 2004 0.390866497812944 660 3523074
SGTC_1793 st048256 72.231 µM -0.277920789050431 0.413489553404855 no 2005 0.390536582489845 668 672022
SGTC_133 0724-0033 378.92 µM -0.278386336029049 0.413348506804436 no 2006 0.390357903691964 663 280309
SGTC_2314 7727897 200 µM -0.27842393736166 0.413337115230045 no 2007 0.390343473159842 650 900724
SGTC_2299 7976368 114.88 µM -0.280441208081552 0.412726076800735 no 2008 0.389569512707468 678 2979718
SGTC_2829 7992743 58.44 µM -0.280644882888354 0.412664394708231 no 2009 0.389491393660788 687 16462845
SGTC_2558 carylophyllene oxide 100 µM -0.280668312972951 0.41265729914004 no 2010 0.389482407387104 685 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_193 1273-0060 1.558 µM -0.280930413032281 0.412577926688669 no 2011 0.389381886688785 694 2847393 YHR072W ERG7
SGTC_972 1319-0219 195 µM -0.283238112367564 0.41187923466828 no 2012 0.388497157280068 680 23903702
SGTC_1638 st008370 60.6 µM -0.283382706637734 0.411835465769101 no 2013 0.388441741701519 657 24207134
SGTC_2592 piperlongumine 83.33 µM -0.284099958832647 0.411618368695814 no 2014 0.38816688925648 679 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3337 9144342 33.5465 µM -0.286478388020591 0.410898662425854 no 2015 0.387255872001541 648 17682949
SGTC_2093 5331342 194.4 µM -0.287409119203136 0.410617107167102 no 2016 0.386899539755922 672 33839
SGTC_283 0987-0079 11.7 µM -0.288039824934199 0.410426338702375 no 2017 0.38665812699579 670 411556
SGTC_1119 parthenolide 318.541 nM -0.28965825013412 0.4099369135109 no 2018 0.38603884957989 717 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1713 st033146 12.748 µM -0.290102327299486 0.409802645390335 no 2019 0.385868977698918 712 674619
SGTC_1723 st034307 2.5525 µM -0.291808575290634 0.409286854489929 no 2020 0.38521649416727 655 867466
SGTC_1714 st033236 13.627 µM -0.292080695343346 0.40920460834615 no 2021 0.385112463163476 703 2916566
SGTC_145 3737-0113 38.366 µM -0.294033931232416 0.408614375687539 no 2022 0.384365987710542 674 6849351
SGTC_203 k066-0004 30.888 µM -0.296172374495322 0.407968414356267 no 2023 0.383549222434715 683 6795412
SGTC_1210 3013-0140 750 nM -0.297351623236832 0.407612304569509 no 2024 0.383099036616482 701 905973
SGTC_222 nsc-310342 10.666 µM -0.300479930707845 0.406667988166017 no 2025 0.381905551270161 693 432556
SGTC_1013 4112-3890 241 µM -0.300800368290217 0.40657129084907 no 2026 0.381783363773878 672 705171
SGTC_2819 7996655 46.38 µM -0.30665397057584 0.404805878249513 no 2027 0.379553384433258 694 6456960
SGTC_2971 9092186 9.93 µM -0.308194945519796 0.404341449542699 no 2028 0.378966999149651 645 25236400
SGTC_1128 3448-9350 235 µM -0.310133810279294 0.403757293832428 no 2029 0.378229601038638 661 619386
SGTC_706 4262-0057 46.9 µM -0.310639594747277 0.403604942537049 no 2030 0.37803731152294 676 883298
SGTC_2465 5809242 33.21 µM -0.313960262522597 0.402605062466726 no 2031 0.376775609868424 704 2731748
SGTC_319 1348-1596 45.5 µM -0.314686268492353 0.402386540765312 no 2032 0.376499935559999 719 5380505
SGTC_769 0302-0231 76 µM -0.315219158490277 0.402226164755473 no 2033 0.376297630072319 701 571869 YER009W NTF2
SGTC_277 nystatin 15.5 µM -0.315579891916739 0.402117609498691 no 2034 0.376160701107502 711 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3208 9114115 49.47 µM -0.316615158640215 0.401806109361996 no 2035 0.375767816094924 721 650895
SGTC_2262 9014885 67.46 µM -0.317226397273076 0.401622223789343 no 2036 0.375535910700206 680 6457424
SGTC_2953 9074162 66.49 µM -0.317903233128453 0.401418629304214 no 2037 0.375279170025303 666 16451992
SGTC_1808 st050063 61.5 µM -0.317964517519018 0.401400196075297 no 2038 0.375255926057185 718 4011993
SGTC_2523 spermine 47.74 µM -0.318211813213714 0.401325816262268 no 2039 0.375162136249581 678 1103 A DNA binding polyamine.
SGTC_216 k038-0035 28.382 µM -0.319613922090427 0.400904167762277 no 2040 0.374630509626111 673 4444231 YPR107C YTH1
SGTC_2704 st078022 71.1 µM -0.319877897165425 0.400824796883317 no 2041 0.374530446882371 721 54697681
SGTC_2201 6605497 169.863 µM -0.320070332541537 0.400766938830104 no 2042 0.374457507396465 714 670741
SGTC_2212 7123476 200 µM -0.321680955875998 0.40028277066534 no 2043 0.37384720331472 677 1085715
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.322357011754368 0.400079587668096 no 2044 0.373591123526233 673 6312947
SGTC_1523 st012844 44.7 µM -0.324813838815473 0.39934143674687 no 2045 0.372660985061622 707 4274103
SGTC_1211 1056-0033 32.3 µM -0.326573088991514 0.398813092861925 no 2046 0.371995400166105 701 6741922
SGTC_2118 5526350 200 µM -0.326996827115343 0.398685862078337 no 2047 0.371835142507278 701 743594
SGTC_3024 9090631 49.47 µM -0.329235429423983 0.398013882696763 no 2048 0.370988872755429 665 25236383
SGTC_554 4483-2211 187 µM -0.330183404602707 0.39772941233921 no 2049 0.37063069277356 677 747107
SGTC_555 4296-0685 37 µM -0.330559948268881 0.39761643341404 no 2050 0.370488451779697 702 2908540 YHR072W ERG7
SGTC_753 1322-0200 289 µM -0.330725656031114 0.397566716841525 no 2051 0.370425860566568 707 5403907
SGTC_127 0180-0333 59.125 µM -0.331698623102898 0.397274835392282 no 2052 0.370058420239316 679 771601
SGTC_1587 estradiol valerate 56.1 µM -0.332220917626224 0.397118175405466 no 2053 0.369861224968186 716 13791 A steroid.
SGTC_129 0088-0017 176.636 µM -0.333812279167005 0.396640955814834 no 2054 0.369260608491238 718 182446
SGTC_680 0417-1641 114 µM -0.336601435274145 0.395804913775358 no 2055 0.368208687045651 683 2835990
SGTC_1817 st052116 64.4 µM -0.336608239490756 0.395802874814057 no 2056 0.36820612206081 692 4361398
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.337091979033985 0.395657924039588 no 2057 0.368023781876285 732 5393153
SGTC_1046 2001-0062 216 µM -0.337705153616674 0.395474209273208 no 2058 0.367792695340885 697 739778
SGTC_1609 st001574 46.4 µM -0.339835875076134 0.394835999323593 no 2059 0.366990064821017 707 3960012
SGTC_362 0310-0100 9.03 µM -0.340751827221753 0.394561732943621 no 2060 0.366645209281309 686 790235
SGTC_2440 5628896 157.78 µM -0.341070243743642 0.394466400734686 no 2061 0.36652535081024 693 5522048
SGTC_2013 4024628 200 µM -0.341652985947121 0.3942919471981 no 2062 0.36630602847958 724 5230760
SGTC_513 4245-1575 41.7 µM -0.344076751035484 0.39356658081255 no 2063 0.365394283317464 673 719745
SGTC_402 epigallocatechin gallate 10 µM -0.344428774356214 0.393461260538468 no 2064 0.36526192617345 709 65064 An antioxidant.
SGTC_2291 7917025 104.35 µM -0.344860467121075 0.393332114963146 no 2065 0.365099636045712 690 2964612
SGTC_1876 myriocin 605 nM -0.344954808835248 0.393303893177711 no 2066 0.365064172535909 727 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_450 aminopyrene 156 nM -0.346133890625311 0.392951224923274 no 2067 0.36462104738515 718 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3202 9113761 49.47 µM -0.347486295736108 0.392546823126444 no 2068 0.364113006143177 725 4798415
SGTC_2737 bleomycin 30.5 nM -0.348469116293052 0.392253008786939 no 2069 0.363743951858332 700 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_91 0417-1751 58.384 µM -0.350510106356795 0.391643050902641 no 2070 0.362977953432503 705 6795624
SGTC_1753 st043925 64 µM -0.351783101276833 0.391262746118548 no 2071 0.362500466378786 715 670181
SGTC_3294 9122953 26.2835 µM -0.352848228758056 0.390944621176021 no 2072 0.36210111246203 703 16459826
SGTC_2594 a-mangostin 100 µM -0.353914235742449 0.390626306600366 no 2073 0.361701579034799 729 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2280 7785178 200 µM -0.354532839460179 0.390441622281544 no 2074 0.361469798914322 675 2954328
SGTC_191 3914-0123 66.505 µM -0.355440077574231 0.390170810798519 no 2075 0.361129964429785 729 3144412
SGTC_883 0850-0245 24.6 µM -0.355633455266147 0.390113094249909 no 2076 0.361057542909351 717 6823229 YPR165W RHO1
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.356442561166715 0.389871630424044 no 2077 0.360754580201095 671 115019
SGTC_3063 1327-0034 4 µM -0.357448531594401 0.389571475014802 no 2078 0.360378025124338 711 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1763 st044482 94.5 µM -0.357901424137056 0.389436365148642 no 2079 0.360208542459523 717 88505
SGTC_3204 9114183 49.47 µM -0.357942576809071 0.389424088876388 no 2080 0.360193143556939 680 17027248
SGTC_3137 9097352 49.47 µM -0.360257415049146 0.388733726455163 no 2081 0.359327321025802 752 44120435
SGTC_1346 1488-2224 62.4 µM -0.361112359042326 0.388478842176613 no 2082 0.359007727291729 706 3722427
SGTC_1500 4488-1866 171 µM -0.361360731434592 0.388404803961321 no 2083 0.358914899623406 733 2900003
SGTC_3327 9140648 26.9345 µM -0.36222476072384 0.388147273981212 no 2084 0.358592038874597 715 8029710
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.363127197587505 0.387878348858804 no 2085 0.358254934285705 749 65057 A dermal irritant. YDR527W RBA50
SGTC_2837 9008476 45.46 µM -0.364971222927214 0.387328998790817 no 2086 0.35756644374721 743 2992805
SGTC_2754 granisetron 64.02 µM -0.365273220945631 0.387239052602612 no 2087 0.357453732997394 742 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1265 0819-1001 68.8 µM -0.3688071422588 0.38618697111896 no 2088 0.35613574032414 704 3106768
SGTC_1486 3970-0793 4.53 µM -0.369639911605697 0.385939169357636 no 2089 0.355825404459671 723 2844330
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.369704431131466 0.385919972642705 no 2090 0.355801364904336 698 442882
SGTC_970 1315-0089 19.5 µM -0.370157257134309 0.385785249637957 no 2091 0.355632661022983 691 6811083 YLR033W RSC58
SGTC_871 0574-0004 149 µM -0.370252793970901 0.385756827654743 no 2092 0.355597071635729 708 9551173
SGTC_2815 7968870 71.43 µM -0.371128190473782 0.385496427838226 no 2093 0.355271027535625 725 2977326 YHR190W ERG9
SGTC_2681 menadione 3.18 µM -0.371203860045199 0.385473921211112 no 2094 0.355242849142747 712 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1134 3477-0009 42.5 µM -0.372024610465395 0.385229827749354 no 2095 0.354937262929966 723 3973534
SGTC_1017 4239-0030 168 µM -0.374576924299893 0.384471053421773 no 2096 0.353987568657322 688 1149593
SGTC_2865 9030313 51.95 µM -0.374918181047421 0.384369635079723 no 2097 0.353860658588287 696 42562754
SGTC_2622 2-methoxyxanthone 59.94 µM -0.375299211412579 0.384256405739872 no 2098 0.3537189762829 700 71034 A hepatoprotective.
SGTC_2130 NSC 7 2.4545 µM -0.375416502850092 0.384221552678526 no 2099 0.353675366719848 712 21448
SGTC_2653 dihydrofissinolide 100 µM -0.377463312404051 0.383613495717695 no 2100 0.352914661929236 700 6857746
SGTC_3263 9137018 49.47 µM -0.377691027326775 0.383545864877663 no 2101 0.352830067051913 707 43844957
SGTC_3320 9137005 35.139 µM -0.382160447657985 0.382219177308686 no 2102 0.351171178730709 724 4908713
SGTC_16 erodoxin 22.806 µM -0.38332978840358 0.381872301553575 no 2103 0.350737627525725 730 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2070 5230947 200 µM -0.384568338735859 0.381504998722306 no 2104 0.350278627687135 745 2835538
SGTC_2798 7813637 45.45 µM -0.384642061689953 0.381483138902508 no 2105 0.350251313258325 744 956368
SGTC_14 0354-0009 295 µM -0.385163032815255 0.381328674930924 no 2106 0.350058315014357 716 1713507
SGTC_1432 4049-0298 68.4 µM -0.385262469578694 0.381299194835167 no 2107 0.350021482207696 728 741646
SGTC_31 0508-1974 57.237 µM -0.385709379824422 0.381166707508132 no 2108 0.349855957654327 691 6810525
SGTC_2300 7976697 71.57 µM -0.386984779560504 0.380788689652043 no 2109 0.349383737973357 692 2236109
SGTC_1849 st056239 19.2 µM -0.387869430453339 0.380526553299048 no 2110 0.349056330774044 741 5393181
SGTC_2281 7943571 200 µM -0.38875891488107 0.380263039988507 no 2111 0.348727247941199 723 1244024
SGTC_964 1287-0107 19.4 µM -0.389215725582198 0.380127729583187 no 2112 0.348558285748827 715 51516812 YPR165W RHO1
SGTC_2658 polymyxin b sulfate 77.05 µM -0.389877380712263 0.3799317688955 no 2113 0.348313610293216 708 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1948 st076329 66.6 µM -0.39124263979909 0.379527521116187 no 2114 0.347808946557821 738 24208413
SGTC_2437 5741531 144.16 µM -0.391808513644007 0.379360006691602 no 2115 0.347599852020493 715 2262990
SGTC_1917 st066507 28.5 µM -0.393329193143984 0.37890995547093 no 2116 0.347038179606682 704 3156428
SGTC_1905 st060207 84.5 µM -0.395446719834308 0.37828353841394 no 2117 0.34625661766243 690 1948547
SGTC_2087 5276107 200 µM -0.397293730925875 0.377737407633292 no 2118 0.34557543489264 711 144405
SGTC_1898 st060199 18.6 µM -0.399654939236949 0.377039593107275 no 2119 0.344705342732938 695 688866
SGTC_2791 5663188 71.43 µM -0.399888738179004 0.376970519652984 no 2120 0.344619233707811 754 54690634
SGTC_551 k048-0028 34.9 µM -0.402078718613239 0.376323704260506 no 2121 0.343813047121399 747 6836383
SGTC_1579 chlormadinone acetate 49.4 µM -0.405282454385277 0.375378099905921 no 2122 0.342634951024146 740 45114258 A steroidal progestin.
SGTC_1047 2043-3044 82 µM -0.407694982059125 0.374666519548109 no 2123 0.34174881095517 778 669592
SGTC_1568 digitonin 820 nM -0.408519206271595 0.374423510437348 no 2124 0.34144626646595 755 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2882 9058044 58.44 µM -0.409980968593607 0.373992656294799 no 2125 0.340909954170431 726 18076804
SGTC_1132 3456-3614 2.5 µM -0.411054946623292 0.373676201748216 no 2126 0.340516122435883 737 3125502
SGTC_585 0kpi-0023 191 µM -0.412694532802388 0.373193251399467 no 2127 0.339915215464802 732 64601
SGTC_2473 5854593 8.94 µM -0.416039021430597 0.372208729580704 no 2128 0.338690724800628 719 2872951
SGTC_3057 9095946 49.47 µM -0.416836279376224 0.371974162605166 no 2129 0.338399082061019 714 24540043
SGTC_1248 0469-0687 58.6 µM -0.416873492561324 0.371963215007061 no 2130 0.338385471573925 736 4017482
SGTC_2685 mycophenolic acid 18.85 µM -0.417317996666199 0.371832456126993 no 2131 0.338222913336839 704 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1434 4073-0095 163 µM -0.417763629637096 0.371701380009826 no 2132 0.338059972532276 740 24133745
SGTC_2847 9005661 71.43 µM -0.418037608128936 0.371620800811734 no 2133 0.337959810358821 721 2991449
SGTC_1736 st036774 51 µM -0.418264048426901 0.371554207210256 no 2134 0.337877036050068 761 1272247
SGTC_2621 lithochol-11-enic acid 100 µM -0.420023533523567 0.371036893110917 no 2135 0.337234130973017 755 6708711
SGTC_1383 3049-0032 20.7 µM -0.421504510171048 0.370601645051214 no 2136 0.336693359238874 743 712864
SGTC_2677 mitomycin C 100 µM -0.422111778422559 0.370423221244182 no 2137 0.336471715564428 717 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_527 4476-4215 268 µM -0.422725634745796 0.370242890097224 no 2138 0.336247725079807 701 4418754
SGTC_2833 9001315 45.46 µM -0.427005912835196 0.368986277395934 no 2139 0.334687510504622 708 2989378
SGTC_1214 0358-0031 63.7 µM -0.428043493026302 0.368681872675548 no 2140 0.334309727757972 762 4301366
SGTC_2442 5158906 48.48 µM -0.428776003638768 0.36846701869919 no 2141 0.334043121782504 712 1893835
SGTC_1222 0366-0074 1.18 µM -0.430104974667702 0.368077320881511 no 2142 0.333559640742898 737 286520
SGTC_524 r073-0010 27.8 µM -0.430800927698633 0.367873298786092 no 2143 0.333306562487058 749 2772106
SGTC_2722 naftopidil 47.16 µM -0.433677276740508 0.367030478663385 no 2144 0.332261404913771 757 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_613 3914-0030 117 µM -0.433873426914328 0.366973026543915 no 2145 0.332190178659061 708 1145395
SGTC_1761 st044296 37 µM -0.434573873274683 0.36676789107866 no 2146 0.331935881334765 727 1826700
SGTC_790 1575-0012 79.1 µM -0.435090178762146 0.366616708183932 no 2147 0.331748485970454 745 378741 YLR208W SEC13
SGTC_1807 st050092 58.9 µM -0.435488866273242 0.366499979959641 no 2148 0.331603809370398 749 5008496
SGTC_2402 5553605 200 µM -0.435669342313 0.366447144020102 no 2149 0.331538326085814 728 6758546
SGTC_2831 7999036 19.48 µM -0.435790341708409 0.366411721805877 no 2150 0.331494425978365 767 2988270
SGTC_2624 nerol 100 µM -0.438003352468974 0.365764070496984 no 2151 0.330691926602985 772 637566 A natural product oil.
SGTC_3085 9117376 49.47 µM -0.438031448854476 0.36575585037026 no 2152 0.330681743062048 724 16480349
SGTC_912 3474-0017 2.18 µM -0.438218743735903 0.36570105530047 no 2153 0.330613861194907 764 3360550
SGTC_1116 jasmonic acid 1.58368 µM -0.438926009180125 0.365494162141245 no 2154 0.330357575035029 762 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2367 9070478 135.38 µM -0.439830528058433 0.365229624353987 no 2155 0.33002992765016 721 572802
SGTC_1477 0139-0234 16 µM -0.44148649746859 0.364745481733603 no 2156 0.329430417278441 728 620880
SGTC_2777 climbazole 1.536 µM -0.441900822591991 0.364624382480462 no 2157 0.329280487685392 742 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1938 st074717 56.4 µM -0.442054368096594 0.364579507516769 no 2158 0.329224931973306 722 17250979
SGTC_3314 9135860 59.4275 µM -0.44207660407207 0.364573009019936 no 2159 0.329216886882932 746 25252478
SGTC_781 4335-2806 94.4 µM -0.444185674229464 0.363956807287579 no 2160 0.328454174381354 771 845254
SGTC_969 1313-0238 134 µM -0.446832148294579 0.36318409115447 no 2161 0.327498128763397 741 5212874
SGTC_1447 4239-0816 81.9 µM -0.44711352761208 0.363101966843176 no 2162 0.327396546113826 749 1341554
SGTC_2963 9082507 9 µM -0.450762007556716 0.362037680388911 no 2163 0.326080543141264 766 16459611
SGTC_2187 6125751 200 µM -0.450898981554458 0.361997744849239 no 2164 0.326031178791001 741 874498
SGTC_484 loperamide 105 µM -0.451189686565457 0.361912993146316 no 2165 0.325926421096343 727 3955 An opioid-receptor agonist.
SGTC_2353 9059630 146.67 µM -0.451241451925478 0.361897902261007 no 2166 0.325907768507996 729 4779114
SGTC_410 α-linolenic acid 100 µM -0.452416084112215 0.3615555256281 no 2167 0.325484631023686 746 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2728 chlorpromazine 9.18 µM -0.45276558561798 0.361453675843277 no 2168 0.325358773550583 776 2726 A thorazine and dopamine antagonist.
SGTC_2942 9052777 62.25 µM -0.453061134659112 0.361367556246126 no 2169 0.325252360205696 766 6469503
SGTC_465 cgp-37157 41 µM -0.453663274095111 0.361192121465333 no 2170 0.325035602134923 725 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3095 9117207 49.47 µM -0.454504730716349 0.360947009947452 no 2171 0.324732793885278 735 17015229
SGTC_2674 ligustilide 100 µM -0.455964510579728 0.360521919885494 no 2172 0.324207749374562 715 5319022 A signalling regulator.
SGTC_254 nsc-64875 3.808 µM -0.456231867072563 0.360444083932969 no 2173 0.324111626085121 752 56993
SGTC_2692 st077426 47.7 µM -0.460080398103128 0.359324296710001 no 2174 0.3227292566853 778 25238571
SGTC_2244 6635614 200 µM -0.46093934490743 0.359074537833701 no 2175 0.322421061357143 731 836499
SGTC_1255 0566-0045 221 µM -0.462734112263558 0.358552861730326 no 2176 0.321777481919794 743 2788469
SGTC_540 1187-0821 17.3 µM -0.464513673267466 0.358035866041512 no 2177 0.321139882771239 779 847520
SGTC_600 1495-0418 41.6 µM -0.465777097949031 0.357668975489836 no 2178 0.320687529877353 745 5377768
SGTC_1445 4239-0156 97.7 µM -0.466569386901442 0.357438966831686 no 2179 0.320403996779245 766 4008346
SGTC_2956 9076196 2.52 µM -0.46709078052157 0.357287629784842 no 2180 0.320217465011728 773 16423868
SGTC_2756 carbadox 75.1 µM -0.467651124333036 0.357125012277124 no 2181 0.320017049213942 746 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_405 ebelactone b 50 µM -0.468597073670536 0.35685054699434 no 2182 0.319678834695259 744 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2206 7254556 146.969 µM -0.46886905583353 0.356771645627732 no 2183 0.319581617985449 735 4398905
SGTC_2812 7970281 58.44 µM -0.468966802894837 0.356743290938638 no 2184 0.319546682517411 761 2233435
SGTC_3344 9148862 3.898 µM -0.470691878263606 0.356243007550108 no 2185 0.31893039254569 775 4905352
SGTC_1865 st057639 52.2 µM -0.475471223317082 0.354858259712374 no 2186 0.31722556975507 740 688818
SGTC_2361 9034121 116 µM -0.476473368408576 0.354568144604742 no 2187 0.316868587992846 762 6496917
SGTC_1531 st059297 52.4 µM -0.476988180321571 0.354419142368071 no 2188 0.316685269147854 738 7566702
SGTC_1150 3909-7983 10.9 µM -0.47854669429462 0.353968196884157 no 2189 0.316130574048927 745 23965914
SGTC_2641 levomentholum 100 µM -0.478574209405025 0.353960237410549 no 2190 0.316120784780406 754 16666
SGTC_2686 alizarin 95.37 µM -0.479371070127229 0.353729752066348 no 2191 0.315837335284445 715 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3161 9100388 49.47 µM -0.482085192676791 0.352945117342923 no 2192 0.314872714112243 768 25236368
SGTC_3139 9095020 49.47 µM -0.483574892313778 0.352514720530714 no 2193 0.314343798569998 747 25236292
SGTC_828 2074-0507 139 µM -0.48553448792636 0.351948851157269 no 2194 0.313648627380311 749 X828
SGTC_2055 5235184 200 µM -0.488332565220228 0.351141423061391 no 2195 0.312657149272545 802 2836034
SGTC_789 1309-1135 70.6 µM -0.488555019080584 0.351077259358985 no 2196 0.312578382400173 735 3092424
SGTC_3097 9117246 49.47 µM -0.489704758570158 0.350745700807959 no 2197 0.312171417042429 740 16423892
SGTC_591 4299-0174 154 µM -0.490166848659769 0.350612476604068 no 2198 0.312007918710923 756 5509088
SGTC_1044 1222-0021 1.78 µM -0.490787501105963 0.350433566536636 no 2199 0.311788375563991 768 4306703
SGTC_1376 2910-0861 41.3 µM -0.490958192115649 0.350384368743165 no 2200 0.31172800882036 768 1112859
SGTC_3034 9090421 49.47 µM -0.493342620497066 0.349697374372225 no 2201 0.310885259137077 761 17173761
SGTC_322 k048-0136 19.3 µM -0.497319312246018 0.34855271694989 no 2202 0.309481947580249 749 6823282
SGTC_2227 7312221 64.1025 µM -0.498123638377711 0.348321365564069 no 2203 0.309198450184689 762 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1955 wogonin 32.4 µM -0.498242979880962 0.348287043718251 no 2204 0.30915639606638 741 5281703 A flavanone.
SGTC_2846 9008642 19.48 µM -0.505527552813175 0.346194409375331 no 2205 0.306594175689131 813 2992898
SGTC_641 4092-0595 30 µM -0.509253745114694 0.345125796445151 no 2206 0.30528718764969 753 786260
SGTC_2856 9022925 19.48 µM -0.512191180927482 0.344284255522289 no 2207 0.304258607339128 755 4944862
SGTC_1061 3448-9325 110 µM -0.513415853880224 0.3439336283867 no 2208 0.303830228986313 790 723482
SGTC_949 1165-0505 146 µM -0.514832009616853 0.343528346499773 no 2209 0.303335207608853 742 6244267
SGTC_3044 9093193 49.47 µM -0.516717203373953 0.342989112243811 no 2210 0.302676792551137 787 25236277
SGTC_307 1501-1223 22.3 µM -0.519657075405873 0.34214883966965 no 2211 0.301651304854012 774 2830329
SGTC_1241 0364-0022 50.8 µM -0.520847987201086 0.341808675963772 no 2212 0.301236335536949 772 4563895
SGTC_390 dec-rvkr-cmk 16.7 µM -0.521278390979421 0.341685770014776 no 2213 0.301086426029986 753 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1779 st039427 55 µM -0.521956435236864 0.341492181985172 no 2214 0.300850331647162 794 1124498
SGTC_448 monastrol 171 µM -0.523329238324268 0.341100361462019 no 2215 0.300372578763027 782 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1426 4048-4480 71.7 µM -0.523764277033315 0.340976229998127 no 2216 0.300221251337419 765 14224343
SGTC_1284 0929-0043 16 µM -0.52405430032258 0.34089348596839 no 2217 0.300120386414948 763 1239883
SGTC_2986 9022445 71.43 µM -0.524225221034698 0.340844725646091 no 2218 0.300060950421171 798 6459286
SGTC_2229 7354935 190 µM -0.525752481562336 0.340409146318138 no 2219 0.299530097151844 783 318112
SGTC_849 0386-0493 241 µM -0.526317403014918 0.34024808289487 no 2220 0.299333846676965 777 726119
SGTC_768 0384-0033 77.3 µM -0.52701895494179 0.340048105646812 no 2221 0.299090212777619 770 3965305 YMR134W ERG29
SGTC_1697 st025554 27.742 µM -0.527248704353029 0.339982625396321 no 2222 0.299010445319632 766 1269519
SGTC_1179 1021-1431 9.29 µM -0.527471150580609 0.33991923120533 no 2223 0.298933222684336 793 2840958
SGTC_763 3453-1109 128 µM -0.528424793302389 0.339647507139495 no 2224 0.298602266496112 778 1560353
SGTC_558 k064-0027 21.3 µM -0.528967506888929 0.339492907442843 no 2225 0.298413995317257 750 5088526
SGTC_52 0329-0193 875 nM -0.529015227959599 0.339479314707427 no 2226 0.298397443124816 796 3739292
SGTC_346 4513-0042 7.16 µM -0.529242077060379 0.339414702504207 no 2227 0.298318765567915 755 2827372
SGTC_1401 3807-4679 7.6 µM -0.531105272529654 0.338884197364896 no 2228 0.29767291536881 780 3291456
SGTC_1039 k821-0043 94 µM -0.531445876638681 0.338787252114707 no 2229 0.297554918814003 771 15992768
SGTC_1741 st038134 10.228 µM -0.533504709583042 0.338201479468085 no 2230 0.296842125895927 784 1272587
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.533619085161816 0.338168949153838 no 2231 0.296802550607211 752 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_634 1611-4317 11.2 µM -0.533655500538008 0.338158592269581 no 2232 0.296789950967806 772 2843522
SGTC_3108 9121785 49.47 µM -0.535406768049106 0.337660659595967 no 2233 0.296184305544025 752 17140271
SGTC_2081 5214970 32.255 µM -0.539069971915326 0.336620031039721 no 2234 0.29491928713617 765 2063512
SGTC_1122 capsaicin 818.572 nM -0.540233101117653 0.336289874921088 no 2235 0.294518143813432 787 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_260 nsc-65238 3.989 µM -0.540882685223517 0.33610554432452 no 2236 0.294294223026982 761 3246252
SGTC_3244 9134489 49.47 µM -0.541393967470844 0.335960486955069 no 2237 0.294118032157025 797 16584271
SGTC_2356 9061756 188.97 µM -0.541981315434173 0.335793878913209 no 2238 0.293915688781538 748 20104043
SGTC_17 0960-0276 49.807 µM -0.543637715646999 0.335324195745 no 2239 0.293345400333946 789 6821114
SGTC_2031 5180455 200 µM -0.544685270729007 0.335027287376093 no 2240 0.292984998431673 794 29949
SGTC_1230 0170-0365 3.77 µM -0.545588797325723 0.33477128375097 no 2241 0.292674313350948 775 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1848 st056003 16.4 µM -0.546038325872194 0.334643943722424 no 2242 0.292519796277509 761 146492
SGTC_2985 9022375 71.43 µM -0.547921305922807 0.334110750066685 no 2243 0.291872969298795 798 4939335
SGTC_1250 0485-0349 40.2 µM -0.548104345444001 0.334058937546924 no 2244 0.291810128499704 779 6842794 YDL195W SEC31
SGTC_2330 7979373 200 µM -0.549849186025227 0.333565188960846 no 2245 0.291211409659166 766 1863007
SGTC_872 0588-0139 234 µM -0.550334425489314 0.333427928850573 no 2246 0.291045008170935 749 2047100
SGTC_1596 piperlongumine 63 µM -0.560100266386147 0.330670218935437 no 2247 0.287705524380352 773 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3302 9125395 16.351 µM -0.560333440217425 0.330604486019686 no 2248 0.287626011085679 766 17599668
SGTC_1137 ixabepilone 100 µM -0.560728962618086 0.330492998145964 no 2249 0.287491159976763 780 154225 A novel microtubule stabilizer.
SGTC_2333 9017922 200 µM -0.561505119428253 0.330274262676579 no 2250 0.287226620667512 782 3163164
SGTC_2635 hydroquinidine 100 µM -0.561640995645396 0.330235976185782 no 2251 0.287180321516696 783 442912 An experimental heart treatment.
SGTC_666 0272-0154 136 µM -0.561978962367107 0.330140753397432 no 2252 0.287065176347693 781 6870312
SGTC_1969 st069479 40.1 µM -0.562848550804811 0.329895795728528 no 2253 0.286769008345567 796 3895485
SGTC_658 3253-0951 102 µM -0.565258552191112 0.32921729467631 no 2254 0.285948958029838 778 1184878
SGTC_819 1013-0258 27.7 µM -0.566398438896155 0.328896571718743 no 2255 0.285561477872074 792 5753198
SGTC_1240 0356-0016 42.1 µM -0.566769333898247 0.328792242403526 no 2256 0.285435453940497 763 4305613
SGTC_2321 7390090 138.78 µM -0.566993377359303 0.328729227523784 no 2257 0.285359340544163 802 649046
SGTC_489 paxilline 115 µM -0.567419716596622 0.328609328008743 no 2258 0.285214528712167 790 105008 A toxic potassium channel blocker.
SGTC_1392 3455-1037 33.9 µM -0.567787368061983 0.32850594744048 no 2259 0.285089679094207 778 981132
SGTC_3014 9081533 49.47 µM -0.567941832395811 0.328462517255851 no 2260 0.285037232804921 815 21367265
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.569574864562598 0.328003505306809 no 2261 0.284483040275231 789 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2693 st077581 40.7 µM -0.570317465844857 0.327794861112278 no 2262 0.284231198401813 792 25238761
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.570331743182281 0.327790850221464 no 2263 0.284226357505588 806 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2222 6885208 172.143 µM -0.571798548223848 0.327378890890017 no 2264 0.283729230479377 765 609514
SGTC_1644 st010134 20.9 µM -0.572804513368864 0.327096482125142 no 2265 0.283388531400746 804 3818134
SGTC_1957 st077035 62.4 µM -0.573386440019376 0.326933160619485 no 2266 0.283191534764371 798 705593
SGTC_771 0250-0039 27.3 µM -0.57443775378917 0.326638186607671 no 2267 0.282835805567373 787 3005115
SGTC_1680 diphenhydramine 100 µM -0.574516503519302 0.326616095637955 no 2268 0.282809167951917 788 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_168 3970-0862 530.542 µM -0.577578982659536 0.325757477442677 no 2269 0.281774199992635 802 3135186
SGTC_2869 9037858 32.47 µM -0.578014289417316 0.325635506632886 no 2270 0.281627235948655 774 27187042
SGTC_3261 9137475 49.47 µM -0.578196770394486 0.325584381913369 no 2271 0.281565639488928 749 17027690
SGTC_2461 5755302 26.15 µM -0.57842816421431 0.32551955826224 no 2272 0.281487541842812 819 2788904
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.578853664912216 0.325400370457876 no 2273 0.281343958536868 803 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3078 9116413 49.47 µM -0.579278656731372 0.325281343018779 no 2274 0.281200582246955 786 17177322
SGTC_2447 5741742 33.78 µM -0.586625835881501 0.323226445008816 no 2275 0.278727513538328 778 1776504
SGTC_3239 9133757 49.47 µM -0.588297559125536 0.322759637952595 no 2276 0.278166291833311 816 17036923
SGTC_1881 5652484 16 µM -0.589331707335628 0.322471005169696 no 2277 0.277819389429633 806 2255129
SGTC_3318 9139014 38.6185 µM -0.593399194103379 0.321336800793432 no 2278 0.276457014052147 805 16643984
SGTC_888 0916-0002 6.97 µM -0.593558264053318 0.321292478442594 no 2279 0.276403801356525 776 2802138 YIL048W NEO1
SGTC_3036 9090181 49.47 µM -0.595382921025249 0.320784248507686 no 2280 0.275793769596051 804 25236586
SGTC_3287 9117173 37.0625 µM -0.600487632048394 0.319364195979291 no 2281 0.274090650529256 777 2789709
SGTC_284 0988-0104 32.6 µM -0.600520451485408 0.319355074651376 no 2282 0.274079717593673 817 4666532
SGTC_1217 1183-1422 255 µM -0.607892695560306 0.317308926016588 no 2283 0.271629322229133 792 2849664
SGTC_2060 5238662 140 µM -0.608105104936619 0.317250054585506 no 2284 0.271558883336185 806 790130
SGTC_1828 st055811 49 µM -0.608168766567345 0.317232411013973 no 2285 0.27153777372933 805 5877589
SGTC_2827 7993847 71.43 µM -0.611735239493209 0.316244641467646 no 2286 0.270356471348435 782 2985692
SGTC_411 enrofloxacin 100 µM -0.614503648330735 0.315478806050573 no 2287 0.269441281481589 793 71188 A bacterial gyrase inhibitor.
SGTC_1144 3486-0183 12.5 µM -0.616605007623483 0.314898027524387 no 2288 0.268747645373022 838 6744069
SGTC_425 3825-7017 13.1 µM -0.617246173704144 0.314720911578853 no 2289 0.268536182089397 804 3397440
SGTC_352 k048-0007 5.11 µM -0.617389722855122 0.314681263347851 no 2290 0.268488849538724 821 6811911
SGTC_2202 7226349 200 µM -0.617466626331476 0.314660023510383 no 2291 0.268463493833246 789 844334
SGTC_1878 temozolomide 1 mM -0.619847582304463 0.314002735110167 no 2292 0.267679069300242 802 5394 DNA alkylating agent.
SGTC_3092 9117248 49.47 µM -0.621683891702222 0.313496204824291 no 2293 0.267074872843474 824 17141857
SGTC_2868 9035608 32.47 µM -0.621907149245401 0.313434645082635 no 2294 0.267001461927901 802 6462614
SGTC_1 0258-0098 57.368 µM -0.622196758604455 0.313354797618679 no 2295 0.266906248581512 780 6790032 YDR047W HEM12
SGTC_1312 1218-2183 165 µM -0.622655708511605 0.313228279617159 no 2296 0.266755397169993 814 6744073
SGTC_1496 4469-0713 57.4 µM -0.62341254091792 0.313019692830188 no 2297 0.266506729454602 818 746691
SGTC_1610 st001799 48.1 µM -0.624172796646399 0.312810222793841 no 2298 0.266257055055154 810 621897
SGTC_936 3005-4620 401 µM -0.624757697747701 0.312649108599176 no 2299 0.26606504921079 814 777207
SGTC_3186 9110464 49.47 µM -0.625180487344398 0.312532671186581 no 2300 0.265926303487794 807 17018021
SGTC_43 0570-0105 72.5 µM -0.625355922660974 0.312484361312278 no 2301 0.265868742116217 811 1114046 YDL195W SEC31
SGTC_45 0kpi-0036 14.9 µM -0.625639861542263 0.312406179484351 no 2302 0.265775593460412 814 2795021
SGTC_2027 5150920 200 µM -0.62595216537941 0.312320197191282 no 2303 0.26567315853837 795 786715
SGTC_445 e6 berbamine 66 µM -0.626621977527504 0.312135821549451 no 2304 0.265453529264846 824 6610268 A calcium/calmodulin antagonist.
SGTC_2408 sulbentine 18.36 µM -0.627830643260856 0.311803237598362 no 2305 0.265057444857618 800 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1995 st072814 61.1 µM -0.629301728614871 0.311398651643268 no 2306 0.264575769945363 791 5769371
SGTC_3252 9135871 49.47 µM -0.629509361517816 0.311341565628694 no 2307 0.264507820945186 826 17682838
SGTC_109 0132-0036 33.701 µM -0.630674501344181 0.311021309497885 no 2308 0.264126687374434 783 67274 A color developer.
SGTC_1078 idebenone 36.1 µM -0.63208375629525 0.310634145825769 no 2309 0.263666074446264 827 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_3123 9126162 49.47 µM -0.633801441088559 0.310162530912786 no 2310 0.263105206302997 791 25239884
SGTC_65 0798-0905 34.986 µM -0.634123890959082 0.310074032459658 no 2311 0.262999986153494 858 3602145
SGTC_1897 st060201 15 µM -0.634722280574194 0.309909829711102 no 2312 0.262804779803514 801 611878
SGTC_2995 9067767 71.4286 µM -0.634755862873802 0.309900615591058 no 2313 0.262793826799553 802 11673567
SGTC_3121 9125696 49.47 µM -0.63750337299049 0.309147174373279 no 2314 0.261898506793932 836 1235365
SGTC_326 k292-0812 17.5 µM -0.638534110753142 0.308864725038466 no 2315 0.261563028390751 811 3579357
SGTC_1824 st053723 68.6 µM -0.638635245231382 0.308837017608754 no 2316 0.261530123629374 815 675225
SGTC_1711 st032263 62.8 µM -0.638666932310664 0.30882833664356 no 2317 0.261519814468921 822 3958979
SGTC_1949 st076024 69.1 µM -0.640592031230498 0.308301138681211 no 2318 0.260893889146387 819 2921930
SGTC_439 amiodarone 34.4 µM -0.642544319407841 0.307766898309963 no 2319 0.260259911370844 820 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_979 1426-2828 121 µM -0.642595943727328 0.307752776924704 no 2320 0.260243157888311 806 747872
SGTC_1495 4469-0029 237 µM -0.642703754181048 0.30772328722768 no 2321 0.260208172283724 803 793680
SGTC_508 roscovitine 141 µM -0.643471495261852 0.30751332077575 no 2322 0.259959102491363 835 160355 A CDKinase inhibitor.
SGTC_1640 st009078 66.4 µM -0.643615048465827 0.30747406797632 no 2323 0.259912544753315 814 690618
SGTC_1278 0874-0585 172 µM -0.644325378879967 0.307279869602801 no 2324 0.259682230920293 804 766306
SGTC_507 nimesulide 162 µM -0.644441920355906 0.307248013299138 no 2325 0.259644454181067 805 4495 A COX2 inhibitor.
SGTC_2203 7227154 166.4 µM -0.645274599497991 0.3070204449933 no 2326 0.259374625094293 805 896304
SGTC_297 0986-0032 24 µM -0.647083611380842 0.30652630456669 no 2327 0.258788915717021 815 2847425
SGTC_2670 beta-carotene 100 µM -0.650070970298204 0.305711062754331 no 2328 0.25782318988989 782 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.650552935083545 0.305579625946299 no 2329 0.257667560154459 798 279621
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.655665986856452 0.304186788725447 no 2330 0.256019529058992 817 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2317 5986382 200 µM -0.655810468969801 0.304147471730543 no 2331 0.255973039819763 846 877883
SGTC_1347 1493-0251 600 nM -0.656056532289892 0.304080517302938 no 2332 0.255893875476329 807 3986378
SGTC_1321 1326-2144 215 µM -0.656475694944876 0.303966477254306 no 2333 0.255759050441529 832 3513030
SGTC_1041 0206-0046 107 µM -0.659188026072805 0.303229004673235 no 2334 0.254887517508204 832 50494
SGTC_2378 9074213 121.43 µM -0.65990276284662 0.303034803702408 no 2335 0.25465811555536 821 657714
SGTC_2965 9082772 38.63 µM -0.660830240647385 0.3027828819091 no 2336 0.254360593502952 765 16459634
SGTC_2023 5144124 124 µM -0.662590426967956 0.302305037687302 no 2337 0.253796451466382 819 2830192
SGTC_947 3447-0010 211 µM -0.66344667181809 0.302072712151395 no 2338 0.253522261540512 830 748350
SGTC_588 3970-1144 52.9 µM -0.664908140309359 0.301676356167558 no 2339 0.253054624411952 796 1888707
SGTC_3169 9102970 49.47 µM -0.666598030963409 0.301218342985981 no 2340 0.252514463587052 829 17027839
SGTC_851 0394-0702 453 µM -0.666661968677213 0.301201020018539 no 2341 0.252494038312634 838 762646
SGTC_1990 st072050 59.8 µM -0.667496431876607 0.30097497585583 no 2342 0.252227544036858 817 17233948
SGTC_2194 5927483 104.545 µM -0.671622546895788 0.299858396100169 no 2343 0.250912010372818 794 760979
SGTC_1183 1254-0324 198 µM -0.672776300018164 0.299546511496974 no 2344 0.250544808816879 812 5799357
SGTC_999 SEC7.066 22.7 µM -0.673241076564239 0.299420913827143 no 2345 0.250396966266509 830 740511 YDR170C SEC7
SGTC_1795 st049545 62.3 µM -0.673886336182969 0.299246583387235 no 2346 0.250191789851617 786 5291882
SGTC_1338 1486-1223 76 µM -0.67699538119853 0.29840725585415 no 2347 0.249204442444836 819 3444526
SGTC_1000 4048-0884 8.67 µM -0.678643708141089 0.297962703368056 no 2348 0.248681820775711 838 13040088
SGTC_1065 prochlorperazine maleate 2.48 µM -0.680824328649723 0.297375056046295 no 2349 0.247991327009692 853 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3292 9120825 59.784 µM -0.680979053449764 0.29733337995692 no 2350 0.247942372281083 834 24824900
SGTC_312 4092-0653 6.84 µM -0.681103266706144 0.297299924273176 no 2351 0.247903075098216 831 1148278
SGTC_1285 0929-0069 65.5 µM -0.681248604891687 0.297260780970378 no 2352 0.247857098870255 820 1206237
SGTC_1263 0774-1208 64.8 µM -0.681820011759927 0.29710690927544 no 2353 0.247676384365798 845 906585
SGTC_1439 4092-1168 46 µM -0.684536429077397 0.296375915558844 no 2354 0.246818246996468 845 2886240
SGTC_2913 7966556 36.57 µM -0.686166514926921 0.295937652192985 no 2355 0.246304055350095 815 2976516
SGTC_2133 5320837 200 µM -0.688000524317825 0.295444918184222 no 2356 0.245726225594616 829 2841355
SGTC_2921 7974240 10.71 µM -0.68836898573337 0.295345971063227 no 2357 0.245610224649962 828 2979074 YDR527W RBA50
SGTC_121 0557-0495 61.343 µM -0.688696171891326 0.295258120838706 no 2358 0.245507242856747 852 3104427
SGTC_2743 auranofin 4.32 µM -0.68969728104706 0.294989395493383 no 2359 0.245192288036408 791 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2904 7225135 42.03 µM -0.692515072265612 0.294233628108382 no 2360 0.244306961963188 867 4446116
SGTC_2939 9044578 71.43 µM -0.694742591154524 0.293636813038224 no 2361 0.243608315722555 846 2653634
SGTC_23 0213-0011 39.996 µM -0.694906715826849 0.293592861589447 no 2362 0.243556881839803 843 627608
SGTC_1235 benzylparaben 21.5 µM -0.695172688012287 0.293521642551392 no 2363 0.243473543132984 849 7180
SGTC_2483 5729050 27.16 µM -0.695530218432712 0.293425919687889 no 2364 0.243361540196125 841 2865180
SGTC_3127 9126946 49.47 µM -0.696143574138646 0.293261737525216 no 2365 0.243169460186134 816 27243249
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.700571956099472 0.292077620273617 no 2366 0.241785092438347 827 6708561
SGTC_2713 st079149 53.4 µM -0.701242538351337 0.291898505628727 no 2367 0.241575833517637 829 3103253
SGTC_2830 7992007 71.43 µM -0.702128865780219 0.291661843289624 no 2368 0.241299401069984 828 1952075
SGTC_1760 st045453 10.4495 µM -0.703289431922907 0.291352090522593 no 2369 0.240937697653866 844 3323419 YIL048W NEO1
SGTC_905 2-aminofluorene 215 µM -0.703576921362387 0.291275383899547 no 2370 0.240848143951178 839 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1502 4534-4282 27.7 µM -0.704112425282599 0.291132528319892 no 2371 0.24068138139036 850 3278949
SGTC_2478 5763493 32.33 µM -0.704145586709312 0.291123682971616 no 2372 0.240671056577717 831 1365576 YLR208W SEC13
SGTC_2992 9074591 71.4286 µM -0.705642604856767 0.290724505034129 no 2373 0.240205211054664 844 17741321
SGTC_1870 st057514 26.5 µM -0.706803929776592 0.290415015671625 no 2374 0.239844166059266 846 5393161
SGTC_1332 1480-0653 17.5 µM -0.707301869982188 0.290282363467136 no 2375 0.239689451856664 829 5749438
SGTC_1184 1269-1718 139 µM -0.708997804380381 0.289830776427884 no 2376 0.239162919678728 830 5403821
SGTC_126 0417-1624 672.48 µM -0.71060511176153 0.28940309307287 no 2377 0.238664487274297 853 41912 YDL195W SEC31
SGTC_171 k064-0041 9.68 µM -0.711353866258894 0.289203960628542 no 2378 0.238432489751443 832 53325
SGTC_2379 9035213 200 µM -0.712902800429466 0.288792223715536 no 2379 0.237952953076383 824 646551
SGTC_2117 5521686 200 µM -0.714877582635012 0.288267688643401 no 2380 0.237342345077706 840 803312
SGTC_2084 5306078 60.6385 µM -0.718540803336722 0.287295867755258 no 2381 0.236211949212206 875 679340
SGTC_2867 9039098 71.43 µM -0.721420620272234 0.286532967219234 no 2382 0.23532538177428 833 6463460
SGTC_856 0433-0016 11.3 µM -0.722068672946368 0.286361422296514 no 2383 0.23512612869513 838 3911780
SGTC_2183 6420625 130.508 µM -0.722614636281154 0.286216939116364 no 2384 0.234958336790461 851 2897619
SGTC_3285 9112818 20.8695 µM -0.724562323972471 0.285701787285336 no 2385 0.234360289760772 854 17017947 YPR165W RHO1
SGTC_3159 9100096 49.47 µM -0.72465854918359 0.285676347727241 no 2386 0.234330765193154 834 25236875
SGTC_1048 3161-0300 24.5 µM -0.725016799300838 0.285581644762529 no 2387 0.234220862207148 836 2165101
SGTC_2790 5423970 71.43 µM -0.725048968081078 0.285573141717345 no 2388 0.234210994953621 856 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2240 6690706 185.951 µM -0.727659760197649 0.284883443528704 no 2389 0.233410944375208 840 805876
SGTC_686 1319-0111 510 µM -0.730838100389652 0.284044889082406 no 2390 0.232439024220359 890 4562600
SGTC_2274 7947094 46.08 µM -0.731101446135688 0.283975462506308 no 2391 0.232358595538407 843 2971028
SGTC_3090 9117696 49.47 µM -0.732345427458849 0.28364761804471 no 2392 0.231978879349449 827 7923821
SGTC_2048 5246248 200 µM -0.733498672114994 0.283343848777016 no 2393 0.231627168719216 829 677046
SGTC_3296 9122258 64.045 µM -0.736636318189354 0.282518170678834 no 2394 0.230671771388613 845 4730474
SGTC_1337 1486-1011 40.3 µM -0.737313170182128 0.2823402074822 no 2395 0.230465962461905 839 X1337
SGTC_2488 5268135 45.7 µM -0.738620863391928 0.281996531434495 no 2396 0.230068625881598 861 1270356 YLR208W SEC13
SGTC_2107 5363541 170.161 µM -0.743602469353521 0.280689159995143 no 2397 0.228558504442269 848 244052
SGTC_90 0870-0863 4.608 µM -0.745591647524122 0.280167940890924 no 2398 0.227957064997625 863 1738164
SGTC_265 mycophenolic acid 32.932 µM -0.747223860616261 0.27974060698362 no 2399 0.227464221710187 858 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1785 bathophenanthroline 24 µM -0.747612411772634 0.279638926030195 no 2400 0.227346988011575 834 72812 An iron chelator.
SGTC_2923 7992654 58.14 µM -0.747679625543482 0.279621338505456 no 2401 0.227326711719368 836 2985126
SGTC_1835 st008666 49.2 µM -0.747775581884828 0.279596230972187 no 2402 0.227297766458433 852 690455
SGTC_1880 MG-132 525 µM -0.748227716329215 0.279477942101639 no 2403 0.227161407909135 840 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2842 9000675 19.48 µM -0.753682269761976 0.278052822582698 no 2404 0.225520015391756 844 2989072
SGTC_3182 9108849 49.47 µM -0.754267955768127 0.277900010540036 no 2405 0.225344169843051 845 17133045
SGTC_2175 5807670 165.306 µM -0.755808196989749 0.277498340104162 no 2406 0.224882100720193 808 241186
SGTC_3042 9091578 49.47 µM -0.756525893429593 0.277311273237227 no 2407 0.22466697688254 848 25236497
SGTC_1821 st053465 65.6 µM -0.758635293656087 0.276761817413903 no 2408 0.224035376970471 860 675086
SGTC_2950 9072895 21.46 µM -0.761730740674316 0.275956483292396 no 2409 0.22311036211667 834 17332245
SGTC_2386 9075165 157.42 µM -0.762053455378318 0.275872589774991 no 2410 0.223014050364924 848 16452277
SGTC_428 3448-4153 16.5 µM -0.763070228295469 0.275608349547296 no 2411 0.222710757086916 852 3834874
SGTC_293 4049-0273 38.5 µM -0.763393055921606 0.275524478733473 no 2412 0.222614509999626 842 1380311
SGTC_1651 st011928 86.1 µM -0.763910583799645 0.275390050873344 no 2413 0.222460264913541 870 720198
SGTC_685 1278-0033 54.9 µM -0.76398042804167 0.275371911304156 no 2414 0.222439453059138 866 3590572
SGTC_2974 9094440 9.66 µM -0.764011155601692 0.275363931094513 no 2415 0.222430297358973 861 25236134
SGTC_1863 st057641 20.1 µM -0.765241438904382 0.275044509545622 no 2416 0.222063894109059 879 3921635
SGTC_1315 1237-0019 3.69 µM -0.766100497127914 0.274821578366561 no 2417 0.221808253614666 848 825140
SGTC_259 usnic acid 108.925 µM -0.766203608693556 0.274794826234896 no 2418 0.221777580744801 886 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_755 1995-0008 37.3 µM -0.766282968068742 0.274774237445544 no 2419 0.221753975151978 840 689533
SGTC_18 0111-0177 500 nM -0.766723205867177 0.274660037112233 no 2420 0.221623051675407 860 721752
SGTC_2557 derrustone 83.84 µM -0.768263053453043 0.274260775609405 no 2421 0.221165459978765 870 629853 An antioxidant.
SGTC_106 0092-0003 11.579 µM -0.768815533296758 0.274117595005392 no 2422 0.221001413123538 851 1072148
SGTC_1656 st012921 11 µM -0.7689521289889 0.274082200578271 no 2423 0.220960864748614 845 6732821
SGTC_1070 indatraline 8.81 µM -0.768992424639325 0.274071759674008 no 2424 0.220948903814857 860 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_329 k048-0121 21.3 µM -0.769053745080026 0.274055871466498 no 2425 0.22093070281636 868 6832902
SGTC_624 k048-0052 28 µM -0.770969800528222 0.273559648369114 no 2426 0.220362416007152 853 6835531
SGTC_3003 9075612 71.4286 µM -0.771320793958833 0.273468795742241 no 2427 0.220258405030629 876 6501993
SGTC_1854 st056233 32.9 µM -0.772214483664185 0.273237536767365 no 2428 0.219993702296492 871 5393174
SGTC_1411 3909-8223 150 µM -0.772288484419016 0.27321839202807 no 2429 0.219971792133714 857 X1411
SGTC_2866 9034245 58.44 µM -0.775030629737713 0.27250944040011 no 2430 0.219160780302899 845 6462273
SGTC_1437 4092-1038 11.6 µM -0.778296211018725 0.271666353459297 no 2431 0.218197204348916 859 3977136
SGTC_3216 9129716 49.47 µM -0.779708070174593 0.271302251162257 no 2432 0.217781363783028 845 8056934
SGTC_2612 dictamnine 15.46 µM -0.77982347804518 0.271272499551384 no 2433 0.217747392461312 844 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.780306077531023 0.271148105275963 no 2434 0.217605368182288 869 641818 YHR062C RPP1
SGTC_2424 5537928 59.2 µM -0.782692198729029 0.270533479776004 no 2435 0.216903942242536 865 5382802
SGTC_1066 ketoconazole 628 nM -0.783168339022282 0.270410917237365 no 2436 0.216764132277949 866 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_3237 9133362 49.47 µM -0.783937820813798 0.270212904795923 no 2437 0.216538298093468 864 43845137
SGTC_1174 0739-0097 51.1 µM -0.784695132802885 0.270018094862151 no 2438 0.216316168581934 873 728447
SGTC_2405 ticlatone 3.52 µM -0.784899733239581 0.269965475777412 no 2439 0.216256179237806 892 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2380 9035439 200 µM -0.786547193947952 0.269541969392877 no 2440 0.215773490910758 875 6462575
SGTC_2751 anetholtrithion 17.25 µM -0.787888827727452 0.269197326894497 no 2441 0.215380868356477 878 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1653 st012112 65 µM -0.788803085615826 0.268962596581766 no 2442 0.215113552894862 865 720429
SGTC_1816 st051957 91.6 µM -0.789482420316151 0.268788247973832 no 2443 0.214915050283676 886 674121
SGTC_2241 6772625 37.8075 µM -0.791254071360791 0.268333827850983 no 2444 0.214397872019498 861 2285411
SGTC_2472 5377652 49.4 µM -0.792573616698197 0.267995621972931 no 2445 0.214013142636263 892 1610903
SGTC_1750 st081859 2.357 µM -0.792830782664434 0.267929734086161 no 2446 0.213938209609615 867 5291695
SGTC_718 1130-0073 349 µM -0.793054181025234 0.267872504340168 no 2447 0.213873128188056 882 6740020
SGTC_651 3253-0966 34.4 µM -0.793816631945652 0.267677227565218 no 2448 0.213651094365209 876 781462
SGTC_3103 9120822 49.47 µM -0.793964099398889 0.267639466899724 no 2449 0.213608165776583 880 17141819
SGTC_504 lovastatin 124 µM -0.795592562043407 0.267222659719589 no 2450 0.21313444559438 874 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_338 4055-0136 114 µM -0.799905166036885 0.266120427864678 no 2451 0.211882872223545 876 2900563
SGTC_1617 st002906 78 µM -0.800291333700354 0.266021842075476 no 2452 0.211771011506865 884 5150859
SGTC_1776 st049249 45.9 µM -0.800509685873457 0.265966106545977 no 2453 0.211707776995987 875 1822314
SGTC_714 4296-0578 26.1 µM -0.800869449970484 0.265874287791749 no 2454 0.211603613878959 878 1589775
SGTC_1550 gossypolone 36.6 µM -0.80581974878517 0.264612509144281 no 2455 0.21017339460153 879 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_457 grayanotoxin iii 135 µM -0.806313114397509 0.264486922606849 no 2456 0.210031165318658 871 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2063 5246145 200 µM -0.808333801784406 0.263972872025042 no 2457 0.209449224446925 883 711240
SGTC_943 3253-1379 105 µM -0.810566222191033 0.263405550470519 no 2458 0.208807410541819 863 668464
SGTC_2738 aclarubicin 5.55 µM -0.811089089768446 0.263272764964753 no 2459 0.208657255412825 843 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1006 4099-6547 255 µM -0.813414418395043 0.262682647535163 no 2460 0.207990247714917 899 3146833
SGTC_659 k018-0002 107 µM -0.816723922975766 0.261843936362376 no 2461 0.207043108374835 896 6797879 YHR007C ERG11
SGTC_1198 1612-1005 86.7 µM -0.81697827130215 0.261779535020914 no 2462 0.206970422774175 892 6998509
SGTC_622 1348-1566 26.3 µM -0.818638042145462 0.261359478401768 no 2463 0.206496477829819 877 7340407
SGTC_493 zm226600 134 µM -0.81867013550289 0.261351359592913 no 2464 0.206487319962893 871 5240098 A potassium channel opener. YCR052W RSC6
SGTC_389 tpck 16.7 µM -0.821297387215617 0.260687170905424 no 2465 0.205738447800845 885 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1322 1348-1070 12 µM -0.821342402405599 0.260675798306327 no 2466 0.205725630725799 859 6758089
SGTC_722 3534-0461 190 µM -0.82197038588495 0.260517171729308 no 2467 0.205546875805777 869 658262
SGTC_58 0957-0393 9 µM -0.82221903478512 0.260454377567362 no 2468 0.205476123617092 874 6997992
SGTC_3260 9137109 49.47 µM -0.823675954440918 0.26008660162247 no 2469 0.205061852840446 846 17478346
SGTC_897 1000-0139 31.4 µM -0.823882995272088 0.260034359228896 no 2470 0.205003021707864 887 6151020
SGTC_2348 9022543 33.42 µM -0.824244508324909 0.259943151997458 no 2471 0.204900320992768 863 3162678 YDL140C RPO21
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.824922929788998 0.259772035522609 no 2472 0.204707673697945 878 16725076
SGTC_2729 fluphenazine 10.66 µM -0.826398432045326 0.259400074229051 no 2473 0.204289056295761 874 3372 An atypical antipsychotic.
SGTC_2088 5278280 127.392 µM -0.827371793282571 0.259154849026478 no 2474 0.204013181469687 891 791502
SGTC_3173 9105693 49.47 µM -0.82832215769716 0.25891553324489 no 2475 0.203744038788347 896 17096658
SGTC_3234 9132280 49.47 µM -0.829726533656211 0.258562100068128 no 2476 0.203346708027692 871 17612295
SGTC_3197 9113331 49.47 µM -0.831812879605589 0.258037500135874 no 2477 0.202757286424133 874 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_639 0833-0042 114 µM -0.832497919854437 0.257865371088556 no 2478 0.202563975915306 901 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_914 3820-6779 408 µM -0.832842868855738 0.257778718824687 no 2479 0.202466676979076 877 2893481
SGTC_866 0495-0101 262 µM -0.834266345119975 0.25742129708401 no 2480 0.202065456125812 863 635694
SGTC_2924 9010168 62.78 µM -0.835185751488046 0.25719057957607 no 2481 0.201806565448328 891 2993929
SGTC_2680 butyl paraben 22.24 µM -0.836639757410492 0.256825928257746 no 2482 0.201397545427703 908 7184 An antifungal and steroid mimetic.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.836776092116035 0.256791750570449 no 2483 0.201359219205171 859 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_102 gallobenzophenone 83.616 µM -0.837266063981688 0.256668939285143 no 2484 0.201221515089541 861 70837
SGTC_1353 1498-1206 8.11 µM -0.837418353265923 0.256630774257632 no 2485 0.201178726461077 849 6756808
SGTC_328 k915-0120 63.5 µM -0.838261533810072 0.256419519323216 no 2486 0.200941917279416 875 6624543
SGTC_2413 inermin 26.06 µM -0.840562300952864 0.255843534207341 no 2487 0.200296592899631 893 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1984 st072354 53.1 µM -0.84080949908688 0.255781689636333 no 2488 0.200227332365433 879 5762938
SGTC_692 k241-0027 77.8 µM -0.841375851436047 0.255640027791768 no 2489 0.200068704747749 866 3600480
SGTC_61 0978-8327 98.565 µM -0.84302547516481 0.255227640625614 no 2490 0.199607098175569 898 6150059 YHR072W ERG7
SGTC_2034 5197015 53.07 µM -0.843823932410412 0.255028160392656 no 2491 0.199383899953133 876 780676
SGTC_647 0140-0236 81 µM -0.844111296907582 0.254956387488314 no 2492 0.199303607772969 889 990837
SGTC_2381 9035592 200 µM -0.844675036185325 0.254815617211377 no 2493 0.199146150612499 901 4749657
SGTC_2287 7945887 168.79 µM -0.84468381715415 0.254813424853986 no 2494 0.199143698606301 872 1245853
SGTC_2712 st079126 47.7 µM -0.845847076634246 0.254523079469403 no 2495 0.198819029719484 878 3152970
SGTC_2586 curcumin 80 µM -0.848423887641999 0.253880534456954 no 2496 0.198100971970607 911 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1370 2001-0092 44.6 µM -0.850337382573209 0.253403943170248 no 2497 0.197568769314919 871 790957
SGTC_3096 9117468 49.47 µM -0.850678464365251 0.253319039850198 no 2498 0.197473994670514 869 41316311
SGTC_2957 9076800 11.52 µM -0.851119659898064 0.253209238040864 no 2499 0.197351442720746 917 16459615
SGTC_1352 1496-0991 99 µM -0.851532317945059 0.253106561107856 no 2500 0.197236859340268 902 3000039
SGTC_1156 4092-0367 4.88 µM -0.851609582820008 0.253087338616484 no 2501 0.197215409560498 884 1357585
SGTC_1709 st033179 39.1045 µM -0.853061863754302 0.252726173019754 no 2502 0.196812499239859 889 573381
SGTC_1035 k081-0041 55.2 µM -0.855596176652481 0.252096569132419 no 2503 0.196110592749646 867 731709
SGTC_482 fipronil 114 µM -0.855842736324611 0.252035360067371 no 2504 0.196042386403412 877 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_173 1273-0061 2.693 µM -0.857067276394259 0.251731481099172 no 2505 0.195703852427151 873 2847414 YPL266W DIM1
SGTC_1423 4048-0112 5.59 µM -0.857655940223854 0.251585468564806 no 2506 0.195541237942887 879 X1423
SGTC_1633 st005664 67.9 µM -0.859914765280391 0.251025603715744 no 2507 0.194918014356829 913 2063822
SGTC_2898 9056270 58.44 µM -0.861458248827306 0.250643420495024 no 2508 0.194492853325824 829 19154699
SGTC_430 0958-0115 16.4 µM -0.861643837543721 0.250597487487626 no 2509 0.194441769936116 898 6833180
SGTC_1118 chelidonine 707.474 nM -0.86204712959449 0.250497688515141 no 2510 0.194330791752555 879 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_873 0591-4978 488 µM -0.862359403096957 0.25042042753471 no 2511 0.19424488661431 886 3305145
SGTC_509 pifithrin 175 µM -0.863290296891817 0.250190185911257 no 2512 0.193988938872256 912 4817 A p53 inhibitor.
SGTC_330 1488-0319 80.1 µM -0.864308367294698 0.249938511144708 no 2513 0.193709257453419 875 6846614
SGTC_3105 9121040 49.47 µM -0.864450298727059 0.249903435287038 no 2514 0.193670285988047 841 41448907
SGTC_1690 st023502 41.2 µM -0.864879448459669 0.249797394372416 no 2515 0.193552479343124 878 24207482
SGTC_890 0929-0006 47.2 µM -0.866179179460133 0.249476382649254 no 2516 0.193195954632562 900 1378169
SGTC_2860 9025725 38.96 µM -0.866958620738327 0.24928397895121 no 2517 0.192982341201591 906 40546248
SGTC_823 0417-1665 178 µM -0.867706929800446 0.249099334444178 no 2518 0.1927773956244 918 3429856
SGTC_1155 4088-0394 48.2 µM -0.868531066289596 0.248896063813034 no 2519 0.192551836499151 897 2326248
SGTC_1649 st011737 51.3 µM -0.869349749647581 0.248694225626538 no 2520 0.192327929645722 838 1761035
SGTC_3332 9141069 11.198 µM -0.871396930772943 0.248189895366607 no 2521 0.191768730527617 896 17332883
SGTC_3345 9148410 3.559 µM -0.873244063195692 0.247735316318389 no 2522 0.191265031167776 868 4903596
SGTC_1206 3978-0017 132 µM -0.874691838039614 0.247379330153259 no 2523 0.190870801156809 894 3873677
SGTC_1364 1653-0028 37.6 µM -0.875012285029468 0.247300574006998 no 2524 0.190783610666802 870 5718652
SGTC_1972 st070201 17.4 µM -0.875613166819813 0.247152931637183 no 2525 0.190620182506686 899 2829099
SGTC_1467 k284-1082 293 µM -0.876351034705619 0.246971694989564 no 2526 0.190419614387995 897 3334705
SGTC_2268 7933382 153.85 µM -0.878395928517659 0.246469795772641 no 2527 0.189864446563207 896 935025 YOR257W CDC31
SGTC_1310 1188-0297 994 nM -0.878680541749869 0.246399983587468 no 2528 0.189787255944573 880 1588352
SGTC_2420 aureobasidin a 50 nM -0.8824264890172 0.245482136465082 no 2529 0.188773108183433 886 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_953 1188-0045 9.7 µM -0.882864013050336 0.24537505249785 no 2530 0.188654874647979 901 6144426
SGTC_2384 9036245 200 µM -0.884184996574305 0.245051894282241 no 2531 0.18829817806685 874 6462766
SGTC_1280 0880-0253 10.1 µM -0.887643486844879 0.244206913489075 no 2532 0.187366276892854 909 6836607
SGTC_1373 2887-0003 58.5 µM -0.888231079504992 0.244063508714175 no 2533 0.187208232002752 912 776948
SGTC_1197 1601-0112 267 µM -0.889074809418972 0.24385767188769 no 2534 0.186981438058888 902 7350313
SGTC_3211 9128781 49.47 µM -0.889410657974239 0.243775764159475 no 2535 0.186891209546762 905 17194361
SGTC_2894 9048625 32.47 µM -0.889713418142472 0.243701938853452 no 2536 0.186809893601636 895 4092861
SGTC_1324 1418-0026 34.4 µM -0.890697961274676 0.243461950459388 no 2537 0.186545614411745 917 1372513
SGTC_1304 1165-0502 251 µM -0.891190797915255 0.243341866490974 no 2538 0.18641341013437 895 767425
SGTC_2446 5162541 200 µM -0.891442399805902 0.243280573828311 no 2539 0.186345939877228 903 1549321
SGTC_2132 5317594 122.667 µM -0.89151659112246 0.243262501696692 no 2540 0.186326047417791 913 794577
SGTC_2021 4019055 173 µM -0.892813323353357 0.242946750198764 no 2541 0.185978575097714 915 44827708 YER133W GLC7
SGTC_2112 5488546 200 µM -0.897376062305051 0.241837497895893 no 2542 0.184759140715274 920 600757
SGTC_342 k048-0088 23.3 µM -0.898016338275603 0.241682059899509 no 2543 0.184588419566441 906 6820570
SGTC_1754 st042065 16.137 µM -0.898274016415116 0.241619519410534 no 2544 0.184519740779643 876 1126236 YIL048W NEO1
SGTC_150 3970-0969 77.2 µM -0.898766456058896 0.241500024923061 no 2545 0.184388535376286 920 6615640
SGTC_2979 9012552 45.46 µM -0.900466457680163 0.241087752457418 no 2546 0.183936033892225 918 17100905
SGTC_3236 9132701 49.47 µM -0.901356937964041 0.240871952239555 no 2547 0.183699284662407 923 24282524
SGTC_2008 4012253 172 µM -0.902146053867755 0.240680804661714 no 2548 0.18348964361056 893 603940
SGTC_2555 cholic acid 100 µM -0.904814082993379 0.240035139766534 no 2549 0.182781944782636 896 6708657 Influences liver metabolism.
SGTC_559 1550-0661 158 µM -0.905970125419125 0.239755670227109 no 2550 0.182475832560229 903 5830875
SGTC_2180 6301957 200 µM -0.908465526297908 0.239153020789479 no 2551 0.181816159732044 899 845462
SGTC_2899 9053889 58.44 µM -0.908680673254579 0.239101100719409 no 2552 0.181759354397368 894 6470052
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.910556519752042 0.238648675550573 no 2553 0.181264544448196 920 6710655
SGTC_1960 st011366 51.8 µM -0.910602846970453 0.238637508072742 no 2554 0.181252334959079 902 3972846
SGTC_480 am 92016 50 µM -0.914482027291841 0.237703421651161 no 2555 0.180231808749433 918 2129 K+ channel blocker.
SGTC_938 3126-1755 342 µM -0.918561207984463 0.236723343703122 no 2556 0.179162565049899 890 1777771
SGTC_1162 k048-0130 20.1 µM -0.921411002771439 0.236039963164234 no 2557 0.178417943230991 904 6797406
SGTC_2570 licareol 100 µM -0.92570712640035 0.235011810815067 no 2558 0.17729910168587 917 443158
SGTC_1903 st060211 78.3 µM -0.926286739438518 0.234873286952595 no 2559 0.177148492695556 893 688960
SGTC_2376 9072922 81.32 µM -0.92728182116859 0.234635573966764 no 2560 0.176890115172144 925 17087968
SGTC_1403 3909-7815 62.9 µM -0.929127748515663 0.234194956799718 no 2561 0.176411442769945 895 6615483
SGTC_462 ag-879 158 µM -0.930157050971919 0.233949464555618 no 2562 0.176144887772965 922 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1199 1638-0010 4.46 µM -0.931463684878825 0.233638033250774 no 2563 0.175806880619509 906 3111136
SGTC_167 3672-0051 66.205 µM -0.931505347696139 0.233628106856997 no 2564 0.175796109818908 899 3237971
SGTC_424 splitomicin 100 mM -0.931935082495103 0.233525733840166 no 2565 0.175685037839088 940 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3037 9091026 49.47 µM -0.933934451498023 0.233049764040707 no 2566 0.175168853103203 909 25236398 YIL048W NEO1
SGTC_499 genistein 192 µM -0.936071686900487 0.232541570016669 no 2567 0.174618139731102 935 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_617 3770-0098 35 µM -0.936824165655334 0.232362791616635 no 2568 0.174424506294812 907 5962639
SGTC_429 1112-0049 25.5 µM -0.937540767831376 0.232192608088579 no 2569 0.174240231735115 919 2836170
SGTC_186 3455-3465 67.277 µM -0.938997409503346 0.231846888881937 no 2570 0.173866037182887 898 755278
SGTC_2802 7925815 54.55 µM -0.939175889393629 0.231804548207479 no 2571 0.173820222916561 921 1262923
SGTC_2296 7971656 126.45 µM -0.940434974106134 0.231505978724841 no 2572 0.173497244773743 901 666570
SGTC_2028 5153890 36.43 µM -0.944223425998616 0.230608909242667 no 2573 0.172527743312242 924 2830968 YPR165W RHO1
SGTC_937 3122-0005 46.7 µM -0.944611224069432 0.230517192053731 no 2574 0.172428697331691 887 759535
SGTC_1985 st071382 65.5 µM -0.945067323136085 0.230409347255342 no 2575 0.172312253284415 946 6123237
SGTC_2157 5649910 96.377 µM -0.945673217492814 0.230266126937414 no 2576 0.172157643467458 925 2858091
SGTC_2449 5812982 45.77 µM -0.946940777659871 0.229966664230617 no 2577 0.171834478736434 928 776185
SGTC_29 0299-0004 12.984 µM -0.950425114464178 0.229144609368341 no 2578 0.170948143938354 909 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2566 crystal violet carbinol 226 nM -0.953584691027954 0.228400601783565 no 2579 0.17014695398902 931 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1677 st019204 53.9 µM -0.95480513026772 0.228113580260994 no 2580 0.16983812626221 916 3945625
SGTC_2368 9071271 200 µM -0.959731340168735 0.226957103703778 no 2581 0.168595222911334 928 27209959
SGTC_51 1013-0126 23.419 µM -0.962219565203536 0.226374227408855 no 2582 0.167969661543862 895 1627850
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.96322296803906 0.226139415859708 no 2583 0.167717820607556 922 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2914 7968218 45.32 µM -0.963774969308906 0.226010297864617 no 2584 0.16757937926987 893 2977111
SGTC_95 0471-0001 561.058 µM -0.964050319084409 0.225945906691143 no 2585 0.167510349360891 915 4015405
SGTC_515 4092-1064 102 µM -0.964786219695923 0.225773865567323 no 2586 0.167325949743366 953 717353
SGTC_1968 st069590 43.6 µM -0.965095236727125 0.225701644704556 no 2587 0.167248556262186 912 6384066
SGTC_2246 7293507 91.5585 µM -0.965892296167987 0.22551542301721 no 2588 0.167049038829331 914 887656
SGTC_2683 piperine 63.03 µM -0.971802531672203 0.22413729614699 no 2589 0.165574398079267 936 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2266 7929956 200 µM -0.97401901977304 0.223621699488292 no 2590 0.165023547796663 916 2967153
SGTC_990 3985-0011 41.3 µM -0.975479119745351 0.223282421700174 no 2591 0.164661327067739 925 5399565 YGL099W LSG1
SGTC_2885 9057732 51.95 µM -0.977221044221568 0.222878040954134 no 2592 0.164229865896289 910 6471414
SGTC_1759 st043059 70 µM -0.983812413752282 0.221351663097598 no 2593 0.162603877271162 945 669426
SGTC_2619 obliquin 87.91 µM -0.984512103522775 0.221189986112343 no 2594 0.162431891655698 911 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1603 st002045 67.8 µM -0.985836113784414 0.220884232629905 no 2595 0.162106770487064 940 5887985
SGTC_1607 st000305 50.6 µM -0.986008579437726 0.220844422983573 no 2596 0.162064451403373 943 5457690
SGTC_3288 9119690 36.221 µM -0.98624400810637 0.220790086435626 no 2597 0.162006694267456 965 17595618 YKL019W RAM2
SGTC_1757 st041620 31.8375 µM -0.987715995957328 0.22045052768826 no 2598 0.161645879128008 958 5289815
SGTC_1171 0368-0077 21.4 µM -0.989845167165041 0.219959899566583 no 2599 0.161124902061812 918 3239779
SGTC_1891 st059073 26.2 µM -0.990038916803895 0.219915284668861 no 2600 0.161077548802687 926 688754
SGTC_2855 9016525 58.44 µM -0.990529391391035 0.219802365875224 no 2601 0.160957715266508 922 43811474
SGTC_460 trequinsin 123 µM -0.99198451122228 0.219467558947665 no 2602 0.160602540549865 965 5537 A vasodilator.
SGTC_345 1362-0200 395 µM -0.993081842414936 0.219215269111216 no 2603 0.160335035957253 963 1419823
SGTC_931 2812-0076 566 µM -0.993643351288725 0.219086235874885 no 2604 0.16019826544613 939 3450959
SGTC_1098 clofazimine 15.1 µM -0.99372895016857 0.219066569318469 no 2605 0.16017742224978 936 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1021 4476-0760 85.3 µM -0.995877392693465 0.218573291889971 no 2606 0.159654860456528 940 746768
SGTC_278 4092-0821 23.9 µM -0.996066018986658 0.218530014288215 no 2607 0.15960903455713 931 877900
SGTC_63 0099-0242 26.702 µM -0.996918341359804 0.218334522653342 no 2608 0.159402074055534 925 3898502 YLR359W ADE13
SGTC_2377 9073351 62.6 µM -0.998940955311434 0.217871012275244 no 2609 0.158911647436259 957 7337946 YHR072W ERG7
SGTC_2931 9014674 55.67 µM -1.00173152728338 0.217232446066507 no 2610 0.1582366377567 943 2996810
SGTC_2516 gossypol 71.55 µM -1.00184674562619 0.217206103928163 no 2611 0.158208808170928 946 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2444 5485484 36.41 µM -1.00194017074613 0.217184745685328 no 2612 0.158186244830705 961 6790631
SGTC_3049 9092223 49.47 µM -1.00579127576912 0.216305387429856 no 2613 0.157257992428004 936 8623917
SGTC_3012 9080433 71.4286 µM -1.00616214616909 0.216220812118066 no 2614 0.157168788990962 927 17688859
SGTC_2261 9010538 184.68 µM -1.00777611944961 0.215852975881491 no 2615 0.156780976347635 938 6457250
SGTC_3015 9080845 49.47 µM -1.0086947330275 0.215643779215498 no 2616 0.156560529263936 933 5296973
SGTC_1673 st016611 27.3 µM -1.01030960763159 0.215276307534693 no 2617 0.156173489769342 957 5226799
SGTC_1820 st053765 18.6 µM -1.01096836219656 0.215126509510095 no 2618 0.156015786233058 928 3690829
SGTC_1524 corynanthine 62.1 µM -1.01201278223862 0.214889136837574 no 2619 0.155765970917857 960 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1615 st002656 86.5 µM -1.01249114466254 0.214780466871026 no 2620 0.15565163930591 949 1584458
SGTC_1629 st005085 44.9 µM -1.01384684779767 0.214472664252722 no 2621 0.155327918550226 907 24207091
SGTC_3099 9120367 49.47 µM -1.0140877134306 0.214418004292616 no 2622 0.155270450112839 937 24824940
SGTC_773 4358-1457 44.6 µM -1.01425460034582 0.214380137173056 no 2623 0.155230640582962 956 1186886
SGTC_3317 9138495 8.753 µM -1.01470468061932 0.214278032058848 no 2624 0.155123311146607 922 17020139
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.01533245342812 0.214135662910665 no 2625 0.154973689694277 947 390807
SGTC_401 neomycin 50 µM -1.0156889750473 0.214054833842729 no 2626 0.154888759867987 905 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_311 1315-0136 58 µM -1.01639957128482 0.213893783459024 no 2627 0.154719574853949 943 6759207
SGTC_2032 5185112 25.99 µM -1.01804029322577 0.213522197891128 no 2628 0.154329403930934 909 5718189
SGTC_2359 9039622 200 µM -1.01825699635659 0.21347314778424 no 2629 0.154277919652313 945 6463596
SGTC_2398 5228213 48.84 µM -1.01988345203651 0.213105214062142 no 2630 0.153891869261567 948 80771 YMR134W ERG29
SGTC_237 nikkomycin 200 µM -1.02082445143857 0.212892511989598 no 2631 0.153668808796376 961 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1839 st053978 48 µM -1.0214048990392 0.212761370306582 no 2632 0.153531322615611 955 3788398
SGTC_2556 citropten 84.59 µM -1.02570062785747 0.211792294796587 no 2633 0.15251635916293 918 2775 A potential DNA crosslinker.
SGTC_3347 9188721 44.724 µM -1.0270329210722 0.211492267674379 no 2634 0.152202481264765 941 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3048 9093155 49.47 µM -1.03050217276509 0.210712174779404 no 2635 0.151387166410826 892 25236002
SGTC_192 3455-0609 60.9 µM -1.03095027857344 0.210611537338072 no 2636 0.151282068481574 928 3769639
SGTC_2786 7743617 45.45 µM -1.03355898990973 0.210026222500663 no 2637 0.150671189845428 928 583674
SGTC_892 0929-0076 29 µM -1.03510241976443 0.209680374648272 no 2638 0.150310541320992 929 5751038
SGTC_1493 4348-0038 111 µM -1.03567281160354 0.209552647488973 no 2639 0.150177405306353 944 800424
SGTC_3110 9122132 49.47 µM -1.0392988048131 0.208741754038961 no 2640 0.149332895265293 934 918317
SGTC_2655 perillic acid 100 µM -1.03996096224024 0.208593873411174 no 2641 0.149179018869729 945 5702197 An apoptosis inducer.
SGTC_2166 5933061 31.504 µM -1.04320921999018 0.207869330198112 no 2642 0.148425702106423 940 2877375
SGTC_1746 st038117 42 µM -1.04454203687046 0.207572467994892 no 2643 0.148117340467599 930 2898218
SGTC_376 3970-0862 59.1 µM -1.04619262098141 0.207205176027369 no 2644 0.147736054539156 944 3135186
SGTC_3038 9091290 49.47 µM -1.04773310221789 0.206862731440222 no 2645 0.147380795931219 935 25236843
SGTC_198 3454-2873 16.191 µM -1.04779105843302 0.206849854480825 no 2646 0.147367441522222 928 710957
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.04780789736041 0.206846113224978 no 2647 0.14736356160854 932 2374 Ca(2+)-ATPase inhibitor.
SGTC_846 0335-0850 148 µM -1.04983897811203 0.206395143608598 no 2648 0.146896075561424 919 6819598
SGTC_2474 5321570 43.32 µM -1.05288829588729 0.205719185441639 no 2649 0.146196095449323 952 2841384
SGTC_1887 st057648 70.8 µM -1.0539484837888 0.205484476214672 no 2650 0.145953251814803 964 688672
SGTC_2049 5262831 67.185 µM -1.05418860355664 0.205431339499976 no 2651 0.145898288330048 939 763417
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.05459238610423 0.205342003832612 no 2652 0.145805893752324 924 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2553 4-methylesculetin 85.09 µM -1.05482754521281 0.205289986225777 no 2653 0.145752102155935 951 5319502
SGTC_3232 9132874 49.47 µM -1.05523610292879 0.205199631159568 no 2654 0.145658678126686 934 3784940
SGTC_2191 5911152 200 µM -1.05535700701778 0.205172897004036 no 2655 0.145631038965914 933 2875902
SGTC_2076 5212012 200 µM -1.05636325052077 0.204950478047325 no 2656 0.145401144459042 942 604802
SGTC_3046 9092212 49.47 µM -1.05701049824749 0.20480748690975 no 2657 0.145253398101963 969 25236637
SGTC_2325 6158266 200 µM -1.05810007265067 0.204566910210952 no 2658 0.145004910656014 942 3623240
SGTC_693 4161-2696 114 µM -1.05871226580571 0.20443181252312 no 2659 0.144865420015674 959 805759
SGTC_1158 4092-0494 91.8 µM -1.0592307848596 0.204317428217149 no 2660 0.144747344085034 942 1148199
SGTC_1362 1611-0397 101 µM -1.06075609934218 0.203981167762359 no 2661 0.144400378944275 952 27816
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.06277068538406 0.203537551549772 no 2662 0.14394297827141 968 91467 include heat shock
SGTC_2387 9077560 195.08 µM -1.0635759451396 0.203360392701301 no 2663 0.143760422152938 949 5303272
SGTC_643 k048-0106 28.4 µM -1.06484437369404 0.203081522420383 no 2664 0.143473180488285 954 6763920
SGTC_2508 celastrol 40.54 µM -1.06696961191663 0.202614790394552 no 2665 0.142992779179973 897 122724 Celastrol is a natural product and antioxidant.
SGTC_732 3970-1727 52.7 µM -1.06959049314122 0.202040091941644 no 2666 0.142401838135216 955 1275699
SGTC_2344 7990960 76.95 µM -1.07226635953723 0.201454344147155 no 2667 0.141800206018506 920 140813
SGTC_149 3970-0822 46.1 µM -1.0728358109984 0.201329822542276 no 2668 0.141672395083434 943 3114250 YBL034C STU1
SGTC_1385 3091-4834 14.1 µM -1.07310538282404 0.201270891528804 no 2669 0.141611918067823 933 4072814
SGTC_2213 7173844 200 µM -1.07736479557543 0.200341115921459 no 2670 0.140658662619475 953 892728
SGTC_2014 4013930 200 µM -1.08046126824482 0.199666817963893 no 2671 0.139968412681349 963 64556
SGTC_1394 3474-0001 65.7 µM -1.08071955016584 0.199610635421811 no 2672 0.139910941975384 928 5017666 YIL048W NEO1
SGTC_3164 9100705 49.47 µM -1.0819600485956 0.199340929714069 no 2673 0.139635140274038 919 17174235
SGTC_2425 5628681 7.85 µM -1.08207534687308 0.199315873034201 no 2674 0.139609524641645 949 5714958
SGTC_783 0848-0141 92.7 µM -1.08353007518225 0.198999893692865 no 2675 0.139286604497929 938 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1351 1496-0003 46.5 µM -1.08399498913028 0.198898974120148 no 2676 0.139183510292528 968 3891978
SGTC_1019 4262-0212 3.4 µM -1.08505581062511 0.198668815521426 no 2677 0.138948468653538 957 4677213
SGTC_1311 1190-0148 100 µM -1.08524034799553 0.198628794217988 no 2678 0.138907609115526 944 1961333
SGTC_1249 0481-0015 10.2 µM -1.08589246334366 0.198487406500381 no 2679 0.138763285844668 940 4227577
SGTC_902 1120-0002 2.07 µM -1.08618666403118 0.198423639561162 no 2680 0.138698208098791 905 3280475
SGTC_491 tetrandrine 80.3 µM -1.08909786046752 0.197793314767924 no 2681 0.138055366653307 954 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2678 equilin 100 µM -1.09024647998782 0.197544951825401 no 2682 0.137802291918156 902 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2363 9053361 176 µM -1.09249530560372 0.197059240481677 no 2683 0.137307726366044 959 6469797 YMR079W SEC14
SGTC_802 4112-3352 742 µM -1.09274600643013 0.197005137818256 no 2684 0.137252667009131 925 704594
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.09633396105144 0.196231822301253 no 2685 0.136466326229173 957 6728940
SGTC_1687 st020778 55.3625 µM -1.09745913682077 0.195989691625163 no 2686 0.136220367193647 955 4259299
SGTC_391 gliotoxin 8.33 µM -1.09951178831436 0.195548441248471 no 2687 0.135772447484703 960 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_3098 9119039 49.47 µM -1.10603914391465 0.19414929564682 no 2688 0.134354788532795 944 17161528
SGTC_2094 5332512 191.667 µM -1.10747935393444 0.1938414082332 no 2689 0.134043366908955 961 755774
SGTC_1546 5-methoxyflavanone 78.7 µM -1.10984129011421 0.193337119343908 no 2690 0.133533711595091 947 147795
SGTC_200 k038-0079 37.545 µM -1.11196343897107 0.192884710075073 no 2691 0.13307693521714 983 3436683
SGTC_2195 6536160 144.242 µM -1.11228772891346 0.192815633482879 no 2692 0.133007229118655 953 3834386
SGTC_2061 5245884 80.95 µM -1.11482965106013 0.192274705502884 no 2693 0.132461713804838 961 573863
SGTC_1032 k061-1018 98.7 µM -1.11509501343803 0.192218289218639 no 2694 0.132404854076869 966 4005393
SGTC_1619 st003326 88.7 µM -1.11521009252742 0.192193826447104 no 2695 0.132380201079642 881 2849032
SGTC_3020 9089140 49.47 µM -1.11722465198363 0.19176589292666 no 2696 0.131949141327892 975 17217859
SGTC_320 4092-0846 5.34 µM -1.11956300944857 0.191269910377265 no 2697 0.131450013032618 941 1359356
SGTC_1246 0422-0085 105 µM -1.11988375292601 0.191201939742197 no 2698 0.131381651320015 954 264295
SGTC_885 0865-0106 16.8 µM -1.121364712908 0.190888292888859 no 2699 0.131066325028927 950 2793380
SGTC_3088 9117578 49.47 µM -1.12178422654821 0.190799503100864 no 2700 0.13097709720986 1000 678341
SGTC_138 0850-0259 40.9225 µM -1.12201230607348 0.190751240854168 no 2701 0.130928603797042 938 6813004
SGTC_1624 st003710 6.25 µM -1.12233850548376 0.190682229193893 no 2702 0.130859270065831 962 24207033
SGTC_1379 2144-0755 36.5 µM -1.12302423951064 0.190537203359541 no 2703 0.130713599951192 961 5392327
SGTC_103 0844-0104 51.839 µM -1.12696188691381 0.189705742209029 no 2704 0.129879297773245 959 5375804
SGTC_779 1360-0071 233 µM -1.12736126227325 0.189621536203881 no 2705 0.129794885181134 949 7566
SGTC_3115 9123671 49.47 µM -1.12750455545116 0.189591329264553 no 2706 0.129764607776529 981 3286988
SGTC_2595 hexamethylquercetagetin 100 µM -1.12973977873617 0.189120516034904 no 2707 0.129292945161358 975 386331
SGTC_1773 st048542 73.5835 µM -1.1309046518897 0.18887544020353 no 2708 0.129047612569864 965 3237138
SGTC_1172 0370-0043 85 µM -1.13122472519659 0.188808134770551 no 2709 0.128980258868617 978 376585
SGTC_2184 6075246 200 µM -1.1346582275728 0.188087063418652 no 2710 0.128259273004069 944 2267320
SGTC_1569 carminic acid 40.6 µM -1.13481165122913 0.188054882570646 no 2711 0.128227121704686 953 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1220 1838-0075 193 µM -1.13779893003983 0.187428973727273 no 2712 0.127602225931115 930 5529645
SGTC_2520 obtusaquinone 4.71 µM -1.13877340578202 0.187225075789608 no 2713 0.127398838354221 935 5967872
SGTC_824 1304-0008 100 µM -1.13882487990016 0.187214309232646 no 2714 0.127388101213312 964 768245
SGTC_623 k072-0108 16.9 µM -1.1389276079006 0.187192823328764 no 2715 0.127366674752597 959 5382803
SGTC_1188 1403-0014 4.57 µM -1.14034298783437 0.186896947157287 no 2716 0.127071717492702 940 9614867
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.14095043456135 0.186770053083065 no 2717 0.126945274887589 946 17037758
SGTC_1575 cyproterone acetate 48 µM -1.14160379506099 0.186633627279905 no 2718 0.12680937292132 983 9880 An androgen receptor antagonist and liver toxin.
SGTC_1961 st076550 68.7 µM -1.14348824303869 0.186240488361574 no 2719 0.126417966674068 956 1579337
SGTC_2844 9010103 25.97 µM -1.1472778558629 0.185451443587305 no 2720 0.125633401517122 975 2480525
SGTC_2532 xanthone 78.9 µM -1.14754881410125 0.185395106292387 no 2721 0.125577435341915 977 7020 An insecticide.
SGTC_1499 4480-0877 67.3 µM -1.14803012633311 0.18529505866236 no 2722 0.12547806364577 945 2861909
SGTC_2788 5282734 71.43 µM -1.14828975051294 0.185241105985339 no 2723 0.125424484443858 953 743706
SGTC_1501 4491-0275 38.4 µM -1.14874799145023 0.185145902433028 no 2724 0.12532995524392 959 5104718
SGTC_2912 7964298 10.93 µM -1.152254654682 0.184418369058226 no 2725 0.124608222287859 952 2975850
SGTC_3348 9149464 3.537 µM -1.15236517135307 0.184395468922651 no 2726 0.124585523335356 960 1951442
SGTC_1228 0124-0032 52.5 µM -1.15282306119838 0.184300608516381 no 2727 0.124491508413391 954 X1228
SGTC_308 4092-1169 104 µM -1.15351667179349 0.184156972017378 no 2728 0.124349189301403 964 2268590 YDL196W YDL196W
SGTC_1185 1319-0113 81.3 µM -1.15452538710963 0.183948206378033 no 2729 0.124142418270814 971 4672763
SGTC_1868 st057644 42.7 µM -1.15468111613559 0.18391598953994 no 2730 0.124110517677249 989 688665
SGTC_1735 st034310 56.75 µM -1.15474493285147 0.183902788309709 no 2731 0.124097446683692 953 871153
SGTC_2591 skatole 100 µM -1.15513028116508 0.18382308706778 no 2732 0.12401853978446 969 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_542 3381-0244 89.3 µM -1.15539969808836 0.183767376591642 no 2733 0.123963392751209 986 1112843
SGTC_2267 7931562 200 µM -1.15828589607345 0.183171223841828 no 2734 0.123373692538027 972 934880
SGTC_3259 9138485 49.47 µM -1.16100933825156 0.18260979628991 no 2735 0.122819050937007 956 17646153
SGTC_2109 5483026 200 µM -1.16307588226471 0.182184503738798 no 2736 0.122399358165482 966 759335
SGTC_975 1335-0046 28.5 µM -1.16381679805975 0.18203217495337 no 2737 0.122249131574084 975 16486740
SGTC_304 1310-0298 97 µM -1.16401026906104 0.181992411345873 no 2738 0.122209925105517 969 1550234
SGTC_3342 9147791 14.508 µM -1.1671294128847 0.181352091381556 no 2739 0.121579055677353 957 1838168
SGTC_1216 1165-0504 9.65 µM -1.1731208671528 0.180126086126097 no 2740 0.120373669779726 983 6304004
SGTC_2052 5265182 7.135 µM -1.17433946347192 0.17987736825105 no 2741 0.120129541174532 956 1239884
SGTC_564 3555-0129 330 µM -1.1748781800104 0.179767483948815 no 2742 0.120021728194545 932 563260
SGTC_1994 st072947 40.9 µM -1.17679998303157 0.179375829270818 no 2743 0.119637674700325 985 5286565 YDL195W SEC31
SGTC_332 4112-0506 40.9 µM -1.178603299866 0.179008809828823 no 2744 0.119278088518583 974 2790355
SGTC_2973 9094665 17.96 µM -1.17958761390314 0.178808677143789 no 2745 0.119082135795005 961 25237061 YIL048W NEO1
SGTC_2297 7971671 152.32 µM -1.18060419366136 0.178602132037651 no 2746 0.118879998447156 982 909016
SGTC_1317 1273-0028 910 nM -1.18092599003954 0.178536781900156 no 2747 0.118816062781922 951 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_597 k018-0003 82.8 µM -1.18251387984406 0.178214535127579 no 2748 0.118500930733316 981 6786234
SGTC_2616 abietic acid 100 µM -1.18659892214244 0.177387201512264 no 2749 0.117692930638909 980 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_119 0121-0043 24.815 µM -1.18673939134817 0.177358795819823 no 2750 0.117665216078771 979 1092378
SGTC_1654 st012436 41.8 µM -1.18847340567649 0.177008379904684 no 2751 0.117323475653044 989 4323132
SGTC_531 3788-1495 174 µM -1.18877639008026 0.176947196641367 no 2752 0.117263835549508 948 2896655
SGTC_560 2332-1943 155 µM -1.19086252790336 0.176526294515631 no 2753 0.116853778590865 952 21177716
SGTC_182 3448-4371 550.524 µM -1.19096262128852 0.17650611546531 no 2754 0.116834129546808 947 3491403
SGTC_212 3807-4682 38.772 µM -1.19318114174889 0.17605923137342 no 2755 0.116399219308458 973 3125501 YBL034C STU1
SGTC_1628 st004252 77.7 µM -1.19534753297727 0.175623539745809 no 2756 0.115975637812406 954 692968
SGTC_2596 sinensetin 100 µM -1.19775540103159 0.175140086172682 no 2757 0.115506127212827 970 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_596 1155-0152 116 µM -1.19845800961785 0.174999175136647 no 2758 0.115369380336676 964 280313
SGTC_1951 sophoraflavanone G 9.2 µM -1.19945008308698 0.174800333256684 no 2759 0.115176491654105 959 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1507 4075-3230 155 µM -1.20037376043525 0.174615329024674 no 2760 0.114997107432843 961 659771
SGTC_1788 fluconazole 20 µM -1.2012956014552 0.174430816602039 no 2761 0.114818278029742 957 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_785 1270-0111 65.3 µM -1.20301304058703 0.17408739053395 no 2762 0.114485637106628 961 6741994
SGTC_2090 5301565 104.445 µM -1.20429969373784 0.173830387986529 no 2763 0.11423688251322 975 2056344
SGTC_3353 9151644 39.2805 µM -1.20441186778773 0.173807993221442 no 2764 0.114215213641979 968 4909158
SGTC_1845 st056753 3.01 µM -1.20711980513875 0.173267929380461 no 2765 0.113693004335249 973 5375839
SGTC_2134 5324836 1.464 µM -1.20859642924032 0.172973886070645 no 2766 0.113408964457845 990 699272
SGTC_2208 7283366 200 µM -1.20860365319167 0.172972448331729 no 2767 0.113407576120997 955 898663
SGTC_1810 st050138 53 µM -1.21088867359416 0.172518056806117 no 2768 0.112969037049756 990 3444541
SGTC_2135 5326629 150.42 µM -1.21274743332792 0.172148992049219 no 2769 0.112613199334328 981 5020077
SGTC_2188 6126565 140.678 µM -1.21311242566022 0.172076580478338 no 2770 0.11254341997123 958 874518
SGTC_2149 5554786 194.827 µM -1.21342710613197 0.172014165988675 no 2771 0.112483284043932 988 745063 YPR165W RHO1
SGTC_1704 st028805 70.8 µM -1.21379775980404 0.171940668177426 no 2772 0.112412480997466 975 2876101
SGTC_1005 4092-0690 4.4 µM -1.21486591654775 0.171728972968518 no 2773 0.112208617558007 987 1529343
SGTC_1946 st076057 65.1 µM -1.21677413809969 0.171351202066444 no 2774 0.111845081193249 971 953009
SGTC_2434 5670830 169.91 µM -1.21915501644867 0.170880604725864 no 2775 0.111392680861295 999 1549830
SGTC_2630 antimycin a 100 µM -1.21996860786052 0.170719982425852 no 2776 0.111238387727033 990 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2124 5246320 200 µM -1.22438113253422 0.169850529126892 no 2777 0.110404241721474 969 579342
SGTC_1101 ebselen 5.29 µM -1.22708481881107 0.169319194329249 no 2778 0.109895356565381 978 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2223 6903751 107.57 µM -1.22791141107139 0.169156963654966 no 2779 0.109740112699486 967 5598863
SGTC_2618 avocadyne 43.43 µM -1.22808829575191 0.169122260449155 no 2780 0.109706912109541 990 3015189
SGTC_2151 5563267 85.4165 µM -1.22926113349045 0.168892275748178 no 2781 0.109486957275029 1005 5310824
SGTC_83 0170-0301 39.027 µM -1.23048160398536 0.168653164054344 no 2782 0.109258405808428 998 3089716
SGTC_2058 5236698 133 µM -1.23181936141566 0.168391323867576 no 2783 0.109008284588209 963 766665
SGTC_1509 1326-1131 80 µM -1.23312271993145 0.168136468174713 no 2784 0.108764991034017 955 768313
SGTC_1764 st044502 93.5 µM -1.2335547493158 0.168052044949336 no 2785 0.108684431790428 974 8407
SGTC_2123 5259487 200 µM -1.23482453259557 0.167804073474905 no 2786 0.108447907482151 984 2173474
SGTC_2426 5582046 32.21 µM -1.23779417094248 0.167225063595814 no 2787 0.10789619518477 975 2251934
SGTC_2428 5615643 7.78 µM -1.23835049125002 0.167116737572533 no 2788 0.107793064791031 973 2253075
SGTC_3199 9111318 49.47 µM -1.23857954742802 0.167072149180194 no 2789 0.107750623108489 957 8548020
SGTC_3149 9097855 49.47 µM -1.23933454795283 0.166925234053056 no 2790 0.107610814746654 971 25236625 YMR079W SEC14
SGTC_2770 toltrazuril 17.5 µM -1.24232951177774 0.166343266899133 no 2791 0.107057505513439 950 68591 Kills coccidiodes.
SGTC_1026 k007-1105 30.6 µM -1.24595824576444 0.165639906153188 no 2792 0.106389862330003 973 7066794
SGTC_1751 st044839 27.194 µM -1.25403744319282 0.164080826643319 no 2793 0.104914198075514 976 5291326
SGTC_2059 5238311 157 µM -1.25628882591235 0.163648068528383 no 2794 0.104505635866312 980 703021
SGTC_1775 st081588 35.1725 µM -1.25662790002604 0.163582956369464 no 2795 0.104444203528648 962 1426443 YGL099W LSG1
SGTC_3021 9087658 49.47 µM -1.25900454583193 0.163127043032897 no 2796 0.104014344968007 969 25237042
SGTC_459 nigericin 15.3 µM -1.25977564688774 0.162979299875995 no 2797 0.103875153673013 994 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3107 9121808 49.47 µM -1.26328699402436 0.162307625235451 no 2798 0.103243029294117 924 662681
SGTC_2676 harmalol 100 µM -1.26448959327602 0.162077998628313 no 2799 0.10302717681016 977 5459187 A monoamine oxidase inhibitor
SGTC_1374 2889-5571 141 µM -1.26563320840742 0.161859830923314 no 2800 0.102822215543679 953 2853281
SGTC_1572 epiandrosterone 68.9 µM -1.26625717733598 0.161740876952482 no 2801 0.102710511441088 976 441302 A steroid.
SGTC_3008 9078912 71.4286 µM -1.27284882131429 0.160487721320454 no 2802 0.101535846502491 1009 16648731
SGTC_56 0957-0365 83.25 µM -1.27297725713923 0.160463367202159 no 2803 0.101513056156444 987 6752360
SGTC_78 0336-0123 156.75 µM -1.27499346601265 0.160081368329143 no 2804 0.101155777347919 970 6765896
SGTC_946 3434-1334 87.4 µM -1.2757820834462 0.159932115665692 no 2805 0.101016281362395 974 4047976
SGTC_2458 5808907 16.39 µM -1.27583048417352 0.159922958375131 no 2806 0.101007724483824 990 2731747
SGTC_161 4065-0411 162.148 µM -1.27994737665629 0.159145308290837 no 2807 0.100281821945865 992 1906281 YLR208W SEC13
SGTC_1734 st037168 69.4 µM -1.28270102493503 0.158626549614193 no 2808 0.099798420347848 998 708907
SGTC_2190 6049624 200 µM -1.28511345770373 0.158172984631044 no 2809 0.0993763197425502 970 2265554
SGTC_577 r071-0003 38.6 µM -1.28588515403111 0.158028076743644 no 2810 0.0992415728209012 1020 4568517 YMR134W ERG29
SGTC_1516 st013856 110 µM -1.28684271197504 0.157848389266178 no 2811 0.0990745581525788 998 5281404 A mutagen and neurotoxin.
SGTC_1837 st055472 66.5 µM -1.29125384432795 0.157022365736878 no 2812 0.098307834855428 994 676091
SGTC_2030 5175110 200 µM -1.29208574375843 0.156866904465293 no 2813 0.0981637261931242 1008 2831986
SGTC_2937 9044753 11.33 µM -1.29273872168221 0.156744950131903 no 2814 0.098050720284011 952 6465530 YGL099W LSG1
SGTC_698 k064-0052 127 µM -1.29708467395546 0.155934862379548 no 2815 0.0973010271067592 1033 5088751
SGTC_842 0271-0008 11.1 µM -1.29837030429597 0.155695750117271 no 2816 0.0970800591695899 966 1221709
SGTC_298 1391-0729 10 µM -1.30013683312153 0.155367590938832 no 2817 0.0967770377717579 995 3237558
SGTC_1450 4112-4260 37.6 µM -1.30082386437018 0.155240087962283 no 2818 0.0966593757033882 980 1633175
SGTC_503 tyrphostin 8 294 µM -1.30198038684771 0.155025610295688 no 2819 0.0964615451889407 1019 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.30302647449836 0.154831781439537 no 2820 0.0962828616428638 997 688664
SGTC_3298 9116858 71.43 µM -1.30338322393113 0.154765716207573 no 2821 0.0962219804871199 1016 2506942
SGTC_201 4262-0159 12.803 µM -1.30623320285968 0.154238606927934 no 2822 0.0957366323958691 1022 1341029
SGTC_2551 apiole 73.87 µM -1.30714449036896 0.154070313297977 no 2823 0.0955818218529928 979 10659 A possible DNA adduct former.
SGTC_1982 st072467 71.9 µM -1.31080855063226 0.153394873120835 no 2824 0.0949612264942476 991 3163533
SGTC_667 1498-1044 59 µM -1.31321264218333 0.152952765420069 no 2825 0.0945556525883198 1009 6739982
SGTC_1213 1315-0166 115 µM -1.31632536424729 0.152381598206817 no 2826 0.0940324305721379 974 768401
SGTC_3035 9091303 49.47 µM -1.32081871567311 0.151559593052792 no 2827 0.0932809088617366 1011 25237002
SGTC_1428 4049-0204 61.7 µM -1.32108393127551 0.151511167318425 no 2828 0.0932366901359959 996 X1428
SGTC_3311 9131146 2.8755 µM -1.32405578626622 0.150969239627736 no 2829 0.0927422590206881 1002 4900406 YPR165W RHO1
SGTC_932 2857-0803 154 µM -1.32473679954367 0.150845236488451 no 2830 0.0926292315927929 994 674898
SGTC_1345 1488-0192 31.4 µM -1.32490828727774 0.150814021623355 no 2831 0.0926007859264232 1001 658348
SGTC_3077 9117319 49.47 µM -1.32532645397166 0.150737923322524 no 2832 0.0925314492788344 1011 17154678
SGTC_811 0416-0114 265 µM -1.32543583631626 0.150718022057422 no 2833 0.0925133188193157 971 6612453
SGTC_2774 tamoxifen 10.92 µM -1.32691210011203 0.15044959851514 no 2834 0.0922688806107375 983 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_539 4859-0462 2.54 µM -1.32786321010509 0.150276830523892 no 2835 0.0921116502150131 970 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1718 roemerine 11.9335 µM -1.32905868513737 0.150059861522252 no 2836 0.0919143046814908 931 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3156 9099931 49.47 µM -1.3322244077487 0.149486317840418 no 2837 0.0913932291799931 1000 18111053
SGTC_3154 9100113 49.47 µM -1.33355937961488 0.149244896048208 no 2838 0.0911741514450458 1001 25237525
SGTC_2723 salbutamol 83.58 µM -1.33656536935586 0.148702234149566 no 2839 0.0906822747098203 990 9884233 β2-adrenoceptor agonist
SGTC_894 0960-0238 55.9 µM -1.33714824036643 0.148597163132758 no 2840 0.0905871266378689 1005 6741907 YDL195W SEC31
SGTC_2096 5468907 200 µM -1.33781477693565 0.148477071024825 no 2841 0.0904784118210557 1006 759785
SGTC_2224 6650123 117.647 µM -1.33876276116272 0.148306381383941 no 2842 0.0903239586507246 1022 2908370
SGTC_3194 9111903 49.47 µM -1.33946335470983 0.148180320143625 no 2843 0.0902099382378981 1007 17087251
SGTC_2528 xanthyletin 44.79 µM -1.34007280252078 0.148070717531671 no 2844 0.0901108386239145 1009 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_689 0833-0039 98 µM -1.34145900733195 0.147821625644251 no 2845 0.0898857352210328 1000 5374726
SGTC_2009 4012297 12.05 µM -1.34763110192971 0.146715948080484 no 2846 0.0888885309972137 981 45595307
SGTC_2715 st079500 56.4 µM -1.34769276903325 0.146704929022008 no 2847 0.0888786093819047 1003 28246688
SGTC_2243 6634756 200 µM -1.34807251062758 0.146637086689714 no 2848 0.0888175309582093 997 885676
SGTC_324 1315-0088 19.6 µM -1.34849131214665 0.146562290564853 no 2849 0.088750206302645 1006 6787421
SGTC_1659 st012954 42.1 µM -1.34877869438203 0.146510980167559 no 2850 0.0887040300135239 1001 24207262
SGTC_2629 bisabolol 100 µM -1.35123060165514 0.146073696953419 no 2851 0.0883107873532482 1013 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_368 fentichlor 4.58 µM -1.35251880822549 0.145844304592249 no 2852 0.0881047030777264 1040 7329 A pesticide.
SGTC_1809 st050081 57.6 µM -1.35260787399732 0.145828453505412 no 2853 0.0880904678064532 1003 5036894
SGTC_2959 9079155 11 µM -1.3559905709096 0.145227290021391 no 2854 0.0875510840771149 1005 16189457
SGTC_2038 4100038 30.985 µM -1.35640688834451 0.145153418652918 no 2855 0.087484871395505 974 3596803
SGTC_1561 5-methoxyflavone 52.9 µM -1.35730120595136 0.144994816448146 no 2856 0.087342762160963 974 94525
SGTC_720 r052-1644 49.9 µM -1.35983034712594 0.144546919106529 no 2857 0.0869418083343763 1002 1422863 YOR257W CDC31
SGTC_1494 4358-1428 177 µM -1.36168233539481 0.144219533731697 no 2858 0.0866490791900887 992 1564571
SGTC_3271 9137798 49.47 µM -1.36488228076117 0.143655041994489 no 2859 0.0861450261388321 949 6498326
SGTC_327 1273-0057 3.96 µM -1.36491546885947 0.14364919521573 no 2860 0.086139809891068 984 3108138
SGTC_512 prima-1 270 µM -1.36781502009083 0.143138998410782 no 2861 0.0856849924836467 1006 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_3152 9099253 49.47 µM -1.36828407464239 0.143056580071398 no 2862 0.0856115868438554 974 25236131
SGTC_2980 9014342 25.29 µM -1.36861158130052 0.142999052355719 no 2863 0.0855603609508592 967 2996599
SGTC_612 0302-0167 22.4 µM -1.36882856831769 0.142960946420484 no 2864 0.0855264342727432 1011 235821
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.36965746460441 0.142815443891404 no 2865 0.0853969261874882 988 77254
SGTC_1325 1431-0015 227 µM -1.37513603386055 0.141856266219548 no 2866 0.0845446374064928 1001 1103340
SGTC_1378 2093-0007 380 nM -1.38024714680289 0.140965363926868 no 2867 0.0837552810761246 1015 3618014
SGTC_734 2023-0417 80 µM -1.38027994186751 0.14095965980148 no 2868 0.0837502341681373 1011 3935732
SGTC_1130 3454-2858 15.9 µM -1.38145149635177 0.140755991172356 no 2869 0.0835700907652295 1000 715628 YIL048W NEO1
SGTC_62 0180-0423 3.232 µM -1.38156113701962 0.140736940938101 no 2870 0.0835532468415632 1000 30102 YGL099W LSG1
SGTC_893 0958-0369 48.9 µM -1.38511006203697 0.140121254551111 no 2871 0.0830094078234992 1007 6819948
SGTC_2231 micatex 6.853 µM -1.38557384691821 0.14004093007964 no 2872 0.0829385343562056 1016 20737 An antifungal of unknown mechanism.
SGTC_1703 st026983 48.3 µM -1.38598779549104 0.139969263356193 no 2873 0.0828753150977555 992 1104023
SGTC_717 1532-0246 73.2 µM -1.38639313443502 0.139899111368874 no 2874 0.0828134458601869 993 9561992
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.38981427569893 0.139307966679086 no 2875 0.0822926409869501 1027 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_777 1315-0167 517 µM -1.3904815869778 0.139192859228197 no 2876 0.0821913434121089 983 4221767
SGTC_682 0kpi-0099 17 µM -1.3907635436957 0.139144242734332 no 2877 0.0821485707361384 998 1714895 YML126C ERG13
SGTC_1976 st070609 63.5 µM -1.3921102660237 0.138912193065184 no 2878 0.0819445049910956 1004 682556
SGTC_1040 k898-0338 155 µM -1.39460080243032 0.13848375080817 no 2879 0.0815681264939799 1004 20969351
SGTC_135 0933-0004 26.348 µM -1.3951024189896 0.138397567725501 no 2880 0.0814924784207451 985 21230617 YGL099W LSG1
SGTC_156 3474-0145 5.642 µM -1.3988211304856 0.137759793447579 no 2881 0.0809333140745831 985 2265471
SGTC_1915 st067105 30.6 µM -1.40690479669094 0.136380338335538 no 2882 0.0797278105250767 994 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1927 st060202 13.8 µM -1.41048323983146 0.13577271470865 no 2883 0.0791985209508679 983 688887
SGTC_1996 st072960 66.8 µM -1.41132053639591 0.135630808902271 no 2884 0.0790750608847062 1006 1719405
SGTC_1360 1598-0022 39.8 µM -1.4115890295159 0.135585325959078 no 2885 0.0790355022316764 1017 761525
SGTC_2111 5486399 200 µM -1.41642547389667 0.13476781777795 no 2886 0.0783254849681383 989 689674
SGTC_3102 9121669 49.47 µM -1.4210872610395 0.133983039318526 no 2887 0.0776456964619466 1036 41905072
SGTC_673 1082-0474 110 µM -1.42769000789583 0.132876897029687 no 2888 0.076690551734035 998 3098046
SGTC_2177 5811945 192 µM -1.42866716653799 0.132713731685274 no 2889 0.076549959536278 1004 5343475
SGTC_2744 captopril 92.04 µM -1.42920390316243 0.132624166478296 no 2890 0.0764728180966733 1028 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3018 9082602 49.47 µM -1.4294994090604 0.132574873204753 no 2891 0.0764303723297727 986 17332089
SGTC_3100 9120536 49.47 µM -1.43230316883178 0.132107806653734 no 2892 0.0760285383042725 1000 16421196
SGTC_2271 7849410 118.62 µM -1.43800423578488 0.131161592241927 no 2893 0.0752164261527297 1021 972430
SGTC_111 0083-0039 52.457 µM -1.44021885006051 0.130795294952527 no 2894 0.0749027458903107 1001 759313
SGTC_1611 st001856 99.4 µM -1.4408264262264 0.130694925549301 no 2895 0.0748168628571352 1027 647478
SGTC_874 0599-0792 117 µM -1.44324275401189 0.130296283896694 no 2896 0.0744760498118969 999 765305
SGTC_3217 9129673 49.47 µM -1.44917563566888 0.129321058116403 no 2897 0.073644269906107 1025 17248312
SGTC_3013 9080133 71.4286 µM -1.45271766755071 0.128741249205261 no 2898 0.0731510797701339 1017 17050193
SGTC_2145 5634607 200 µM -1.45392245309519 0.128544444883764 no 2899 0.0729839034952608 1022 308662
SGTC_2429 5902844 64.44 µM -1.4539636021235 0.128537726790672 no 2900 0.072978198816824 1002 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_210 3551-0445 56.827 µM -1.4549315984379 0.128379759584703 no 2901 0.0728440994754004 1023 2865180 YOR207C RET1
SGTC_605 1315-0399 119 µM -1.45751081839027 0.127959515143939 no 2902 0.0724877136363008 1020 24020461
SGTC_860 0443-0016 25.1 µM -1.45797691661456 0.127883673650397 no 2903 0.072423452869975 1017 5337942
SGTC_683 panaxydol 45 µM -1.45873294979436 0.127760721625186 no 2904 0.0723193117187906 1020 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2078 5212016 200 µM -1.46320305871211 0.127035436636167 no 2905 0.0717059120508945 1019 1899708
SGTC_826 1683-5028 118 µM -1.46346832444933 0.126992486936711 no 2906 0.0716696374461541 1012 722377
SGTC_1636 st007707 68.9 µM -1.46358317930872 0.126973893695268 no 2907 0.0716539356220085 1010 403051
SGTC_3329 9141233 27.5565 µM -1.46798532336222 0.126262681733836 no 2908 0.0710541048045523 987 4909101 YNL103W MET4
SGTC_1853 st056710 91.2 µM -1.46851434422286 0.12617740017178 no 2909 0.0709822813880335 1019 269167
SGTC_878 0828-0289 13.7 µM -1.47263356260205 0.125514729097221 no 2910 0.0704249348913932 994 745350 YLR208W SEC13
SGTC_2669 eugenol 100 µM -1.47325932002634 0.125414274511865 no 2911 0.0703405626316757 1013 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_566 0958-0068 16.5 µM -1.47467318222709 0.125187509946016 no 2912 0.0701502146845685 997 6815365
SGTC_1715 st032160 10.2275 µM -1.47479016340252 0.125168760564507 no 2913 0.0701344832998718 1010 5289825
SGTC_2710 st078562 53.7235 µM -1.47716702917957 0.124788228500021 no 2914 0.069815434734339 1019 17250908
SGTC_1789 tunicamycin 25 nM -1.47818010040364 0.124626283526519 no 2915 0.0696797893859583 999 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2764 methyldopa 94.69 µM -1.47992514141804 0.124347673760773 no 2916 0.0694466126643121 1022 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3168 9103419 49.47 µM -1.48424563581955 0.123659747445013 no 2917 0.0688718834677435 1026 16649256
SGTC_255 tunicamycin 200.472 nM -1.48793718633448 0.123074078920019 no 2918 0.0683837298462453 990 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1193 1488-0126 41.5 µM -1.48921164222534 0.122872337320241 no 2919 0.0682158230115991 1017 1384710
SGTC_852 0418-0143 439 µM -1.4892309330286 0.122869285440841 no 2920 0.0682132839364197 972 5369229
SGTC_2583 asiatic acid 100 µM -1.49091686375116 0.12260276999662 no 2921 0.0679916616438875 1023 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_985 1493-0307 8.71 µM -1.49341220588573 0.12220904592139 no 2922 0.0676646599299094 1025 3278274
SGTC_2211 7117706 200 µM -1.49430779550689 0.122067953265513 no 2923 0.0675475942723557 1006 822771
SGTC_2593 nobiletin 86.24 µM -1.49520002259812 0.121927504133536 no 2924 0.0674311238249853 1002 72344 An anti-infammatory.
SGTC_3112 9123419 49.47 µM -1.49606626389059 0.121791254167968 no 2925 0.0673181940963992 1036 17015854
SGTC_1778 st046819 58.9 µM -1.49636416104302 0.121744423040962 no 2926 0.0672793917859999 1032 671715
SGTC_2960 9079389 5.97 µM -1.49729149540573 0.121598721807953 no 2927 0.0671587134131012 1019 16457355
SGTC_183 3914-0051 30.55 µM -1.49756523148997 0.121555736286532 no 2928 0.0671231228662448 1019 1596232
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.49885074314184 0.12135401175537 no 2929 0.0669561785941649 1022 5282309
SGTC_1058 3448-5425 97.3 µM -1.50126079631816 0.120976456953976 no 2930 0.0666440603186042 1021 7279705
SGTC_2627 acetyl isogambogic acid 100 µM -1.50135313796959 0.120962007327706 no 2931 0.066632123883886 1018 6857789 A caspase activator and apoptosis inducer.
SGTC_3200 9114385 49.47 µM -1.50152609900624 0.120934945643622 no 2932 0.0666097707316252 999 17018030 YLR208W SEC13
SGTC_3340 9146634 11.102 µM -1.50688446513472 0.120098679103236 no 2933 0.0659201370276407 1016 4907387
SGTC_234 nsc-17383 10.7 µM -1.50839325763876 0.119863942754553 no 2934 0.0657269538080162 1000 408974
SGTC_1384 3089-0840 101 µM -1.51250414775749 0.119226016667949 no 2935 0.0652028291330617 1021 1069836
SGTC_2007 4011539 71.82 µM -1.51350781617246 0.119070632476591 no 2936 0.0650753586347672 1012 45595301
SGTC_2657 nystatin 74.44 µM -1.518078868715 0.118364767736525 no 2937 0.0644972587637102 1017 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1634 st006576 41 µM -1.52169440225196 0.117808553828504 no 2938 0.0640428354369275 1016 3915356
SGTC_2487 5918373 44.05 µM -1.52216496285783 0.117736299003307 no 2939 0.0639838759077742 1035 2876279
SGTC_300 r073-0011 5.04 µM -1.52479628331825 0.117332836405868 no 2940 0.0636549586184894 1029 2735780
SGTC_3165 9101544 49.47 µM -1.52909594519409 0.116675674658895 no 2941 0.063120330211266 1033 5002184
SGTC_1936 st074407 74.3 µM -1.53586361802662 0.115646595487469 no 2942 0.0622859163969907 1027 809813
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.53785424391555 0.11534513562764 no 2943 0.0620421285444905 1003 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3073 9114972 49.47 µM -1.53921900098528 0.115138780159055 no 2944 0.0618754202034967 1025 41905075
SGTC_3242 9133940 49.47 µM -1.54088147479464 0.114887763796523 no 2945 0.0616728176337066 1023 17248444
SGTC_510 ag-490 170 µM -1.54131185319562 0.114822844583895 no 2946 0.0616204527170563 1041 5328779
SGTC_1682 st012968 530 nM -1.54407051615217 0.114407341584008 no 2947 0.0612856252873082 1006 24207270
SGTC_2233 sulbentine 40.3845 µM -1.54657677846574 0.114030783535879 no 2948 0.0609826664194069 994 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2430 5571206 200 µM -1.54692467357341 0.113978583256344 no 2949 0.0609407052946257 1020 1731771
SGTC_3076 9116187 49.47 µM -1.54695774227414 0.113973622315311 no 2950 0.0609367179115132 1018 27241210
SGTC_3132 9126706 49.47 µM -1.547954607097 0.113824145635848 no 2951 0.0608166129073166 1021 850858
SGTC_1015 4130-4525 82 µM -1.54798856517951 0.11381905619224 no 2952 0.0608125248071813 1024 1363237
SGTC_1924 st058459 75.1 µM -1.54826426696891 0.113777741584902 no 2953 0.0607793419437959 1013 688683
SGTC_996 3970-0799 1.8 µM -1.5504914951593 0.113444377737588 no 2954 0.0605117966232746 1014 6615648 YGL040C HEM2
SGTC_3218 9131285 49.47 µM -1.55334015015496 0.113019016856308 no 2955 0.060170946515764 1022 17156417
SGTC_1323 1348-1351 11.2 µM -1.55376569800278 0.112955571942698 no 2956 0.0601201577326172 1017 6989654
SGTC_2138 5575593 77.673 µM -1.55745676316858 0.112406337496356 no 2957 0.0596810391569305 1020 762213
SGTC_1888 azatryptophan 97.5 µM -1.55865098183891 0.112229045685556 no 2958 0.0595395047232603 1026 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3321 9137793 26.8275 µM -1.56140690867137 0.111820668135071 no 2959 0.0592138864192427 1028 4904192
SGTC_2804 7954240 19.48 µM -1.56193666034485 0.111742290638779 no 2960 0.0591514555121647 1022 828705
SGTC_1300 1094-0077 113 µM -1.56625834204613 0.111104359456225 no 2961 0.0586440746221151 1035 5532636
SGTC_2644 guaiazulene 100 µM -1.56691263299401 0.111008006166196 no 2962 0.0585675571908277 1012 3515 A coloring agent.
SGTC_3304 9125678 46.087 µM -1.56847378175943 0.110778347460314 no 2963 0.0583853020030013 1040 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_942 3253-1115 227 µM -1.57609775596381 0.109661684515215 no 2964 0.0575016380697527 1023 46497897
SGTC_2701 st077767 14.721 µM -1.57631804510394 0.109629539922 no 2965 0.0574762625034694 1024 5721188
SGTC_546 peri-Naphthalide 147 µM -1.57634551072874 0.109625532612161 no 2966 0.0574730992984964 1021 223824 A penicillin ester.
SGTC_162 k030-0015 37.8 µM -1.57829132260566 0.109341900936055 no 2967 0.0572493492454697 1043 1809920 YMR134W ERG29
SGTC_2491 paeonol 100 µM -1.58275403975089 0.108693383888143 no 2968 0.0567387679753894 1054 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3308 9128332 17.569 µM -1.58516724420144 0.108343854260381 no 2969 0.0564641703169614 1017 17332805 YDL196W YDL196W
SGTC_294 k038-0071 157 µM -1.58692047756478 0.108090422923971 no 2970 0.056265328206526 1042 24152826
SGTC_741 4582-0002 126 µM -1.59030475605539 0.107602430270572 no 2971 0.0558830635509328 1028 2912688
SGTC_511 blebbistatin 171 µM -1.59153138613723 0.107425950126015 no 2972 0.0557450188812998 1044 3476986 A myosin inhibitor.
SGTC_2499 avocadenofuran 51.48 µM -1.5943183736922 0.107025750878405 no 2973 0.055432372215411 1027 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.59533529730852 0.106879993194152 no 2974 0.0553186382025077 1025 23665772 A membrane-active detergent.
SGTC_951 1171-0579 82.7 µM -1.59913452787842 0.106336709023854 no 2975 0.0548953570758595 1017 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1068 loratadine 26.9 µM -1.60256252466816 0.105848224743489 no 2976 0.0545156365312895 1046 3957 A H1 histamine antagonist.
SGTC_427 1354-0053 47.3 µM -1.60399623270504 0.105644405297557 no 2977 0.0543574415045707 1048 6813657
SGTC_711 k292-0785 179 µM -1.60601167535798 0.105358365105653 no 2978 0.0541356723455954 1020 4146315
SGTC_703 3875-0075 71.8 µM -1.60812121740862 0.105059570480297 no 2979 0.0539043165782775 1062 2850814
SGTC_1161 k007-0610 110 µM -1.6089196701559 0.104946638129862 no 2980 0.0538169538895586 1010 5843850
SGTC_1335 1486-0900 202 µM -1.60931840408647 0.104890274518113 no 2981 0.0537733684215045 1024 X1335
SGTC_795 0685-0265 78 µM -1.61290889432178 0.104383722571655 no 2982 0.0533821512793757 1031 302754
SGTC_674 0498-0004 451 µM -1.62436007888405 0.102780018850666 no 2983 0.0521494909574821 994 4231473
SGTC_3258 9138477 49.47 µM -1.62461607942937 0.102744372507744 no 2984 0.0521221944084198 1059 4970355
SGTC_3349 9149703 23.001 µM -1.62652366562386 0.102479036920213 no 2985 0.0519191515747903 1039 4910494
SGTC_1605 st000082 49.1 µM -1.63237385076125 0.101668413279689 no 2986 0.0513003771507091 1009 1114022
SGTC_1922 5578187 25 µM -1.63432685342763 0.101398840095909 no 2987 0.0510951190240172 1004 1350412
SGTC_383 2324-0395 7.37 µM -1.63516570299002 0.101283213580053 no 2988 0.0510071578772203 961 3146421
SGTC_3114 9122766 49.47 µM -1.63681331444455 0.101056387518212 no 2989 0.0508347414334994 1006 17176985
SGTC_1367 1812-0510 76.9 µM -1.63756277298304 0.100953332443233 no 2990 0.0507564670682449 1033 1142582 YDR527W RBA50
SGTC_1614 st002383 48.6 µM -1.64230007114472 0.100303697621623 no 2991 0.0502639161926141 1036 1947235
SGTC_1268 0828-0275 2.46 µM -1.64656947842016 0.0997208442132568 no 2992 0.0498232841388183 1043 745337
SGTC_2154 5570129 200 µM -1.64906737327809 0.0993809845909696 no 2993 0.0495669164419758 1062 673366
SGTC_1699 st031318 29.054 µM -1.64936270671492 0.099340858032502 no 2994 0.0495366750566492 1035 5340658
SGTC_2773 thioridazine 9.09 µM -1.65091581061159 0.099130034803224 no 2995 0.0493778834686668 1035 5452 An antipsychotic.
SGTC_224 benfluorex 43.875 µM -1.65373491515737 0.0987481969974436 no 2996 0.0490906925938182 1055 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_463 ikarugamyin 104 µM -1.65490093530577 0.0985905787343308 no 2997 0.0489722972598039 1070 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_744 1594-0068 283 µM -1.65900327205072 0.0980375039739214 no 2998 0.0485575664818273 1048 668392
SGTC_101 0490-5701 117.494 µM -1.66111441409066 0.0977537685676792 no 2999 0.0483452350433638 1021 4661669
SGTC_147 4466-0538 29.23 µM -1.66392034008765 0.0973775873095773 no 3000 0.0480641748330152 1037 6742687 YHR072W ERG7
SGTC_2932 9016711 44.54 µM -1.66630198069337 0.0970591227415094 no 3001 0.0478266412164649 1043 7117328
SGTC_1033 k072-0102 21.3 µM -1.66702590431567 0.0969624738968747 no 3002 0.0477546270360559 1026 5965931
SGTC_738 1315-0003 72.4 µM -1.66766401347623 0.0968773404822707 no 3003 0.0476912214948862 1052 6251474
SGTC_272 doxorubicin 8.13 µM -1.6704029977806 0.0965125418713793 no 3004 0.0474198284711508 1051 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1658 st012944 20 µM -1.67064638074002 0.0964801751809313 no 3005 0.0473957727881027 1038 24207260
SGTC_2 0422-0095 29 µM -1.67297944443082 0.0961703133704799 no 3006 0.0471656713520185 1015 6790840
SGTC_2991 9074669 71.4286 µM -1.67701227197974 0.0956364266737495 no 3007 0.0467700410628994 1028 17333109
SGTC_2507 purpurin 79.67 µM -1.67774791578596 0.0955392739670209 no 3008 0.046698160523888 1038 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2085 5307070 144.047 µM -1.6783846794602 0.0954552385135359 no 3009 0.0466360132572728 1042 2840351
SGTC_1165 k072-0275 30.3 µM -1.68004115810404 0.095236883352739 no 3010 0.0464746540483835 1039 6153523 YGL055W OLE1
SGTC_2416 tofa 880 nM -1.68195315790215 0.0949853032058652 no 3011 0.0462889617469835 1027 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_847 0342-0274 5.54 µM -1.68546974276991 0.0945238712567745 no 3012 0.0459489888574164 1034 18097
SGTC_1934 st074720 32.6 µM -1.68566687934125 0.0944980528031589 no 3013 0.0459299898269794 1023 17250992
SGTC_1202 1988-0068 29.6 µM -1.68651370916676 0.0943872048852583 no 3014 0.0458484484127083 1039 2850480
SGTC_1983 st071813 46.9 µM -1.68727136550317 0.0942881108521519 no 3015 0.0457755921719041 1042 11838595
SGTC_1010 4112-3296 15.2 µM -1.68731271659463 0.0942827047431448 no 3016 0.0457716185298505 1028 704384
SGTC_1071 trifluoperazine 6.31 µM -1.69177454338853 0.093700722175862 no 3017 0.0453444845549723 1065 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_344 k064-0035 6.43 µM -1.69275555972303 0.0935731188336646 no 3018 0.0452510024385794 1009 5088750
SGTC_3166 9102297 49.47 µM -1.694423126706 0.0933565086020264 no 3019 0.0450924539928006 1036 25237072
SGTC_3032 9089427 49.47 µM -1.6946444275948 0.093327790372406 no 3020 0.045071446852947 990 17173707
SGTC_2567 aureobasidin a 60 nM -1.7035971335293 0.0921714633634486 no 3021 0.0442281886852939 1027 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2575 plumbagin 510 nM -1.70688658848706 0.0917492741904974 no 3022 0.0439215670318384 1034 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1405 3909-7894 12 µM -1.71367506701282 0.0908825304135832 no 3023 0.04329420923421 1006 7104060
SGTC_615 k087-0205 167 µM -1.71471976749628 0.0907496856420877 no 3024 0.0431983087849158 1043 9642773
SGTC_1492 4158-0558 28.5 µM -1.71710029391968 0.0904475147933882 no 3025 0.0429804242562004 1019 3967268
SGTC_2988 9073640 71.4286 µM -1.71856153211246 0.0902624036976651 no 3026 0.042847120614014 1047 9102229
SGTC_1106 tegaserod maleate 11.7 µM -1.7289207300713 0.0889581518799163 no 3027 0.0419116416741648 1033 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_635 k038-0028 24.7 µM -1.73331034052687 0.088409739301078 no 3028 0.0415202619151606 1056 4035102
SGTC_24 0417-1663 219 µM -1.73915726566447 0.0876831760380633 no 3029 0.041003552006791 1068 4329390
SGTC_813 k007-0158 173 µM -1.74239942977519 0.0872822160260613 no 3030 0.0407192878176187 1049 6523916
SGTC_2137 5261020 140 µM -1.74804645886781 0.0865871162283965 no 3031 0.0402279914803831 1050 763655
SGTC_5 0352-0601 109.883 µM -1.75716466762063 0.0854734921198236 no 3032 0.039444872868586 1032 762456
SGTC_1942 st076330 65.2 µM -1.76366233416097 0.0846864894153297 no 3033 0.0388944230973513 1045 24208414
SGTC_1855 st056195 39.6 µM -1.76508844167583 0.0845144876803462 no 3034 0.0387744514568913 1007 4028379
SGTC_986 1493-0483 84 µM -1.76786773435826 0.0841800325873676 no 3035 0.0385415089957732 1047 40079
SGTC_784 4579-0127 173 µM -1.76942528448932 0.0839930347129705 no 3036 0.0384114646021879 1055 1948547
SGTC_960 1222-0186 7.7 µM -1.77192744623988 0.0836932810074104 no 3037 0.0382033008654599 1049 3126296
SGTC_3060 1327-0027 12.5 µM -1.77685153948197 0.083105733113611 no 3038 0.0377963347105484 1023 16000455 YPR107C YTH1
SGTC_1267 0828-0272 9.49 µM -1.78038216582862 0.0826863683190255 no 3039 0.0375067192034452 1051 745334
SGTC_1799 st045822 46.1415 µM -1.78243060720735 0.0824437873459344 no 3040 0.0373395189912557 1015 3674992
SGTC_1149 3909-7961 23.3 µM -1.78540123589649 0.0820929513755814 no 3041 0.0370981291679285 1052 735261
SGTC_2403 6032726 181.2 µM -1.79136624645539 0.0813918726362788 no 3042 0.0366172708700314 1046 2881040
SGTC_153 4077-0274 519.67 µM -1.79200891746063 0.0813166086305792 no 3043 0.0365657687873879 1038 3121976
SGTC_3158 9100007 49.47 µM -1.80072011640865 0.08030160191066 no 3044 0.035873502644359 1061 19297233
SGTC_2046 4110841 106 µM -1.80611091949929 0.079678292548758 no 3045 0.0354505077630529 1045 44119630 YMR134W ERG29
SGTC_1084 voriconazole 435 nM -1.80916659924339 0.0793266099761223 no 3046 0.035212562477213 1054 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2091 4-phenylthiadiazole 200 µM -1.81017530158648 0.0792107753105472 no 3047 0.035134303224827 1057 270010
SGTC_746 1095-0025 46.6 µM -1.81035415116112 0.0791902504339455 no 3048 0.0351204422494131 1052 6749286
SGTC_3316 9136639 10.545 µM -1.81104279783319 0.0791112585609588 no 3049 0.035067113511653 1030 4903665
SGTC_743 1275-0778 158 µM -1.81474162008688 0.0786880022428982 no 3050 0.0347818128926821 1038 2849257 YMR203W TOM40
SGTC_3045 9092950 49.47 µM -1.81706737642513 0.078422746010702 no 3051 0.0346033986624018 1052 44120432
SGTC_375 3970-0961 9.27 µM -1.82017544106229 0.0780693253205858 no 3052 0.0343661459216355 1040 2898222
SGTC_2716 st080858 38.6235 µM -1.82231401731587 0.0778268486084189 no 3053 0.0342036762560451 1041 5296050
SGTC_369 0957-0393 4.5 µM -1.82362046539348 0.0776790020072438 no 3054 0.0341047352085352 1055 6997992
SGTC_268 camptothecin 39.6153 µM -1.82372641040502 0.0776670218977915 no 3055 0.0340967220158883 1066 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_354 2783-3500 4.88 µM -1.82729892438152 0.0772638677760641 no 3056 0.033827418439561 1045 6740761
SGTC_1635 st007035 42.4 µM -1.83322577103268 0.0765985393561614 no 3057 0.0333845014526785 1008 3716403
SGTC_739 1486-1183 203 µM -1.8334496266525 0.0765734957250687 no 3058 0.0333678666141548 1055 4346692
SGTC_727 3032-0951 202 µM -1.83486710575173 0.0764150611726388 no 3059 0.0332626913123263 1063 3652836
SGTC_296 1222-0039 74.9 µM -1.84139671489855 0.0756884524196426 no 3060 0.032781721937553 1060 5984176
SGTC_965 1291-5240 308 µM -1.84542980822128 0.075242290286391 no 3061 0.0324875201747276 1054 2834598
SGTC_3249 9135183 49.47 µM -1.84569462740706 0.0752130648857726 no 3062 0.0324682788787939 1015 4902779
SGTC_331 k048-0133 24.5 µM -1.84650892429737 0.0751232534397538 no 3063 0.0324091723919101 1058 6813582
SGTC_1937 st074714 47.2 µM -1.84668445130563 0.0751039047145633 no 3064 0.032396443240745 1049 17250970
SGTC_521 r062-0005 13.8 µM -1.84800615872345 0.0749583320454219 no 3065 0.0323007259477187 1056 2832033
SGTC_157 1348-1695 65.819 µM -1.85289266006822 0.0744220017825477 no 3066 0.0319488726836544 1030 5380510
SGTC_1281 0884-0031 11.8 µM -1.85532065374484 0.0741566031347482 no 3067 0.0317752252733453 1060 1548255
SGTC_1067 clotrimazole 1.36 µM -1.86288574203702 0.0733343145319184 no 3068 0.0312391716116917 1045 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_79 0052-0007 94.094 µM -1.86629391771045 0.0729661489727634 no 3069 0.0310001276482105 1041 2801472
SGTC_857 0438-0306 1.35 µM -1.86827599692977 0.0727526879676858 no 3070 0.0308618052746133 1053 4686136
SGTC_2277 7947813 106.88 µM -1.87094240391231 0.0724662826533552 no 3071 0.0306765323380544 1059 1246798
SGTC_1113 artemisinin 1.17947 µM -1.87213028483072 0.0723389679035843 no 3072 0.0305942905348446 1024 2240 An anti-malaria and mitochondrial poison.
SGTC_266 formosanin C 406 nM -1.87264245206429 0.0722841277317601 no 3073 0.0305588875073974 1028 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_525 k781-2675 26.7 µM -1.87432468412741 0.0721042273385809 no 3074 0.0304428436474822 1029 3651118 YDL195W SEC31
SGTC_1143 3454-2408 5.08 µM -1.87806049859956 0.0717059414371409 no 3075 0.0301864446664393 1011 X1143
SGTC_2451 5856223 45.7 µM -1.89539142956412 0.0698802836730797 no 3076 0.0290202816440088 1050 2179896
SGTC_573 3702-0553 84.7 µM -1.89654884896591 0.0697596459904531 no 3077 0.0289437535144888 1059 1222756
SGTC_1272 0839-0021 27 µM -1.91424362977142 0.0679352193800058 no 3078 0.0277945166846297 1067 5027250
SGTC_528 3492-0019 172 µM -1.91462179764259 0.0678966342852973 no 3079 0.0277703766083467 1053 2869262
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.91978956855428 0.0673710523503463 no 3080 0.0274422425154238 1058 521171
SGTC_2679 rapamycin 1 nM -1.92581449980054 0.0667622706514057 no 3081 0.0270637701491106 1011 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1125 tnp00248 1.32998 µM -1.93244598247811 0.0660971311996203 no 3082 0.0266522415983958 1061 24207736
SGTC_661 1304-0007 33.6 µM -1.93252701612316 0.0660890353691913 no 3083 0.0266472454171388 1071 3117130
SGTC_1655 st012546 55.1 µM -1.93625942314989 0.0657169736148176 no 3084 0.0264179679047805 1073 720985 YLR208W SEC13
SGTC_406 estrone 100 µM -1.93979885276178 0.0653656506075103 no 3085 0.0262020700714101 1054 5870 A steroid.
SGTC_124 0136-0217 7.121 µM -1.94149607232549 0.0651977025931652 no 3086 0.026099067685497 1046 3976905
SGTC_89 0302-0250 142.109 µM -1.94238426989099 0.0651099447460399 no 3087 0.0260452990697933 1077 4203518 YLR208W SEC13
SGTC_723 4182-0001 115 µM -1.94334436906624 0.0650151858324954 no 3088 0.0259872819997639 1052 744821 YLR208W SEC13
SGTC_875 0709-0210 25.7 µM -1.94448969091649 0.0649022860441375 no 3089 0.0259182136992631 1069 6251364
SGTC_1114 scopoletin 1.73284 µM -1.9552479181014 0.063849213066645 no 3090 0.0252769076094408 1068 5280460 A coumarin with genotoxic properties.
SGTC_3333 9141820 12.094 µM -1.95552625954515 0.0638221449335387 no 3091 0.0252604935095103 1048 1939433
SGTC_1266 0828-0227 32.9 µM -1.95868035945687 0.0635160384883642 no 3092 0.0250751159879692 1071 3913820
SGTC_855 0428-0020 25 µM -1.96412583381362 0.0629902440080947 no 3093 0.0247577504963226 1050 6812414
SGTC_248 streptozotocin 5.23457 mM -1.979976698999 0.0614790320663182 no 3094 0.0238530734951533 1070 5300 DNA alkylating agent.
SGTC_3064 1327-0027 10 µM -1.99307407188515 0.0602518294142247 no 3095 0.0231266683446366 1055 16000455 YPR107C YTH1
SGTC_2781 5567276 71.43 µM -1.9959782436418 0.0599823281015427 no 3096 0.0229681454964645 1048 2853274
SGTC_2225 6654152 15.4 µM -1.99824602518813 0.0597725396613423 no 3097 0.0228449969885234 1050 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2524 avocatin b 10.57 µM -2.00981164883135 0.0587115527884723 no 3098 0.0222255637147537 1071 6710748
SGTC_1264 0783-0040 158 µM -2.01020619557503 0.0586756209967612 no 3099 0.0222046849798031 1062 2855798
SGTC_1521 st012942 49.4 µM -2.0148149415897 0.058257174954631 no 3100 0.0219620214441844 1065 24207259
SGTC_1813 st051246 8.6015 µM -2.02946654889225 0.0569424565351559 no 3101 0.021205396393144 1070 5291959
SGTC_696 1560-0013 611 µM -2.03146423191108 0.0567650246309468 no 3102 0.0211039621809481 1066 1650269
SGTC_28 pentachloropyridine N-oxide 1.606 µM -2.0327364897653 0.0566522513313489 no 3103 0.0210395763122721 1070 140250 A respiratory chain inhibitor.
SGTC_1186 1319-0216 26 µM -2.03556557123671 0.0564021133974677 no 3104 0.020896998960013 1069 4565136
SGTC_1050 3232-1156 69.3 µM -2.03670934430561 0.0563012322465149 no 3105 0.020839588785111 1067 700529
SGTC_764 1951-2361 146 µM -2.0407751315643 0.0559437796097867 no 3106 0.0206365917537032 1049 5438930
SGTC_2332 7982454 138.89 µM -2.04083079689231 0.0559388981218175 no 3107 0.0206338241535513 1071 2981748
SGTC_1237 0330-0133 46.1 µM -2.042026025597 0.055834165361527 no 3108 0.0205744749021938 1058 X1237 YHR072W ERG7
SGTC_2475 5812728 15.03 µM -2.04217406349028 0.0558212042112481 no 3109 0.0205671341343327 1066 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1133 3473-0247 50 µM -2.04317496033004 0.0557336350408854 no 3110 0.020517560767265 1031 711311
SGTC_3257 9139206 32.98 µM -2.04509816446866 0.055565676856002 no 3111 0.0204225906098231 1071 4910041
SGTC_2232 chlorophetanol 41.5365 µM -2.04706049113945 0.0553947140793361 no 3112 0.0203260727762293 1079 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_77 0828-0286 12.516 µM -2.05544066308924 0.0546692824602107 no 3113 0.0199182306720343 1057 745345
SGTC_381 3461-2219 42.7 µM -2.06088991681216 0.0542016106661248 no 3114 0.0196567717364817 1076 2883159
SGTC_1511 0906-3109 28.5 µM -2.06180737878761 0.0541231835417092 no 3115 0.0196130391464145 1075 2882180
SGTC_2011 4012611 177 µM -2.07037267852628 0.0533953246359465 no 3116 0.0192087291662517 1058 2049887
SGTC_2736 butenafine 14.65 µM -2.07740734511574 0.0528033555168389 no 3117 0.0188819894242397 1066 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1514 1189-1591 158 µM -2.08034268694012 0.0525578904116058 no 3118 0.0187470560431084 1072 767698 YMR146C TIF34
SGTC_2875 9039966 71.43 µM -2.08435581037272 0.0522237633890629 no 3119 0.0185639071149736 1079 6463691
SGTC_762 1165-0429 115 µM -2.08524495494032 0.052149963230863 no 3120 0.0185235355742264 1061 5967793
SGTC_3131 9127911 49.47 µM -2.08864273366078 0.0518687059990305 no 3121 0.0183699476874008 1058 45595681
SGTC_2328 6201408 200 µM -2.0944245237569 0.0513928801527062 no 3122 0.0181110900298211 1059 2890418
SGTC_514 4466-0038 2.65 nM -2.11003086401688 0.0501258411663607 no 3123 0.0174278487474254 1033 5722064
SGTC_2522 biochanin a 4.94 µM -2.11034761084075 0.0501003855141816 no 3124 0.0174142127254719 1068 5280373 A possible chelator.
SGTC_3247 9135149 49.47 µM -2.11517663188127 0.0497135716951627 no 3125 0.0172074479111627 1061 8934436 YOR116C RPO31
SGTC_1882 5615643 20 µM -2.12062032548749 0.0492803824314685 no 3126 0.0169768831301301 1055 2253075
SGTC_765 1319-0117 244 µM -2.13168400841664 0.0484092647492861 no 3127 0.016516416163901 1051 3487746 YGL099W LSG1
SGTC_1327 1436-0082 2.18 µM -2.1443179072483 0.0474296216866866 no 3128 0.0160037114709351 1074 15992205
SGTC_1011 4112-3381 17.4 µM -2.1476861238555 0.0471711470123493 no 3129 0.0158693492180326 1065 2877139
SGTC_1913 st060213 96.1 µM -2.15134099876031 0.046891953045905 no 3130 0.0157246472328888 1070 688959
SGTC_1772 st048439 82.2 µM -2.15515155591165 0.046602279418275 no 3131 0.0155749881999582 1060 2927068 YDL195W SEC31
SGTC_2350 9023895 38.85 µM -2.1574804454423 0.0464259484062008 no 3132 0.0154841245727066 1057 2997209
SGTC_697 0508-1955 564 µM -2.15917501059972 0.0462979819711211 no 3133 0.0154182959949568 1070 6243113
SGTC_1829 berberine 14.4 µM -2.17177976687423 0.0453549893902629 no 3134 0.0149361392622416 1019 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3274 9138298 49.47 µM -2.17484097106058 0.0451283205369914 no 3135 0.0148210178208668 1079 17015756
SGTC_2976 9009005 19.48 µM -2.18268930858455 0.0445513481105498 no 3136 0.0145293489006156 1055 2993148
SGTC_454 lyso-paf C-16 6.67 µM -2.18437582378118 0.0444281425388078 no 3137 0.0144673216171123 1078 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2587 piperic acid 92.2 µM -2.18606727166326 0.0443048525112908 no 3138 0.0144053420054628 1064 5370536
SGTC_2724 maprotiline 69.64 µM -2.18668317995553 0.0442600273554299 no 3139 0.0143828301678093 1056 4011 A tricyclic antidepressant.
SGTC_2305 7443522 69.23 µM -2.19121633982897 0.0439312323217101 no 3140 0.0142180703594137 1059 5415886
SGTC_862 0452-0056 10.2 µM -2.19310140623432 0.0437950875933009 no 3141 0.0141500368686266 1083 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1831 st055328 12 µM -2.19343549061098 0.0437709946366596 no 3142 0.0141380088137575 1065 1103068
SGTC_1104 tacrolimus 29.8 µM -2.19378481885723 0.0437458137845034 no 3143 0.0141254413561354 1063 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2077 5212015 200 µM -2.19386535845551 0.0437400098552091 no 3144 0.0141225452237819 1070 780900
SGTC_2163 5671233 125 µM -2.19496485703977 0.0436608387471635 no 3145 0.0140830593750094 1058 701023
SGTC_299 1273-0059 1.44 µM -2.20071700422308 0.0432485294717773 no 3146 0.0138780321332928 1044 2848077
SGTC_1742 st038235 28.8875 µM -2.20619355890386 0.0428589020018101 no 3147 0.0136852250404637 1066 564103 YBR002C RER2
SGTC_2254 7938975 95.19 µM -2.20805547427573 0.0427270847002975 no 3148 0.0136202031677343 1072 2969277
SGTC_3339 9145883 14.936 µM -2.21531061391545 0.0422165687991761 no 3149 0.0133693759138974 1044 2030670
SGTC_1657 st012939 43.4 µM -2.21869266070849 0.0419802798410492 no 3150 0.0132538203406329 1075 24207257
SGTC_2800 7887935 81.82 µM -2.21919105384583 0.0419455499567554 no 3151 0.0132368647226653 1082 2961002
SGTC_1057 3448-5381 134 µM -2.2244685399598 0.0415792205478097 no 3152 0.0130584684439978 1038 5497911
SGTC_1909 st060837 51.5 µM -2.23052819211535 0.0411617993478775 no 3153 0.0128561989938527 1053 678937
SGTC_1287 0971-0001 34.6 µM -2.2347543259279 0.0408726967738126 no 3154 0.0127167409495771 1070 4665869
SGTC_128 0906-2981 13.371 µM -2.24484627213021 0.0401889846761386 no 3155 0.01238900154271 1074 6740226
SGTC_97 0535-0701 19.132 µM -2.24739405126695 0.0400178538331674 no 3156 0.0123074274269885 1044 2832013 YGL099W LSG1
SGTC_839 0122-0028 230 µM -2.24951207184715 0.0398760404489436 no 3157 0.0122399678281635 1070 759448
SGTC_1081 sertraline 6 µM -2.25447264799815 0.0395455003603904 no 3158 0.0120832247501467 1068 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2666 tannic acid 100 µM -2.25719125322793 0.0393652978750561 no 3159 0.0119980633674938 1069 16134267 A thiamine antagonist.
SGTC_1358 1509-0022 2.48 µM -2.26148550656848 0.0390820153811337 no 3160 0.0118646045911672 1078 3258434
SGTC_363 0455-0021 3.06 µM -2.26152400599197 0.0390794831844092 no 3161 0.0118634139370284 1039 4597466
SGTC_865 0488-0499 301 µM -2.26646970225969 0.0387553021960641 no 3162 0.0117113200770245 1074 9634651
SGTC_310 1273-0058 1.06 µM -2.27102815645457 0.0384584474999148 no 3163 0.0115726367573814 1033 2734232
SGTC_1301 naphtanilide LB 4.81 µM -2.27103953472522 0.0384577088519859 no 3164 0.0115722923845663 1063 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2316 5844804 197.44 µM -2.28487078178237 0.0375683335332876 no 3165 0.0111602028688988 1067 776813
SGTC_1724 st037281 8.293 µM -2.28662579675327 0.0374566931421244 no 3166 0.0111088370959704 1062 574124 YDL195W SEC31
SGTC_1608 st001473 40.5 µM -2.28806060405996 0.03736562330268 no 3167 0.0110669960336416 1071 7292267
SGTC_2511 berberine 10.47 µM -2.28927943974131 0.0372884037282255 no 3168 0.0110315607577872 1060 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_483 fpl-64176 144 µM -2.29946820842071 0.0366479798691875 no 3169 0.0107391833174533 1082 3423
SGTC_709 3807-1509 243 µM -2.3009045234987 0.0365584269346428 no 3170 0.0106985141879517 1080 1886677 YPL242C IQG1
SGTC_2301 7769476 200 µM -2.30437405512049 0.0363428432361146 no 3171 0.0106008275619955 1068 977820
SGTC_93 0109-0045 59.227 µM -2.30786106081913 0.0361272233145332 no 3172 0.0105034327212129 1084 88733
SGTC_1476 4112-3294 3.34 µM -2.30882152612193 0.0360680170399806 no 3173 0.0104767435015201 1039 704369
SGTC_933 2914-0560 114 µM -2.31706700764546 0.0355630007300072 no 3174 0.0102500409453448 1078 463887
SGTC_2470 5664817 21.68 µM -2.32245343620932 0.0352362358057861 no 3175 0.0101042664522369 1088 2859561
SGTC_2071 5230951 39.92 µM -2.32306264661454 0.0351994339024868 no 3176 0.0100878936300524 1084 1799272
SGTC_306 1672-3436 11.6 µM -2.32447345286825 0.0351143293068721 no 3177 0.0100500663896641 1084 6797378
SGTC_1959 st077091 55.8 µM -2.32509293662046 0.0350770133368768 no 3178 0.0100334956319344 1072 821356 YKL052C ASK1
SGTC_1512 0259-0544 12.2 µM -2.32971366929849 0.0347996987691091 no 3179 0.00991064479782186 1070 18476
SGTC_2312 7706453 155.7 µM -2.3326252850075 0.0346258836605306 no 3180 0.00983391033707867 1081 976098
SGTC_2311 7694451 200 µM -2.34301512243599 0.0340114431573768 no 3181 0.00956430387821701 1079 2163142
SGTC_3143 9086658 49.47 µM -2.34796752497197 0.0337217362574781 no 3182 0.00943808350277505 1058 25236626
SGTC_3276 9139060 49.47 µM -2.35185142912525 0.0334959579650823 no 3183 0.00934011723768127 1081 4870619
SGTC_1847 st056231 15 µM -2.36080467300817 0.0329802283680409 no 3184 0.00911766622271559 1073 5393180
SGTC_1121 fusaric acid 630.51 nM -2.36934311881314 0.0324945057398022 no 3185 0.00890985658979939 1073 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_607 4491-0986 66.8 µM -2.37171898883853 0.03236040509853 no 3186 0.00885277550538577 1031 698981 YDR232W HEM1
SGTC_2810 7959871 45.46 µM -2.3730429200183 0.0322858771271004 no 3187 0.00882110686704252 1069 2974535
SGTC_3181 9108277 49.47 µM -2.3897457479018 0.0313577342391786 no 3188 0.00843002004184097 1085 17097298
SGTC_2925 9010536 32.5 µM -2.39116050244334 0.0312801430929961 no 3189 0.00839760443127756 996 2994177
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -2.39598892168986 0.0310165268603666 no 3190 0.00828779564742431 1075 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -2.39616585478596 0.0310069019034511 no 3191 0.00828379586597971 1079 7104
SGTC_177 1327-0068 8.361 µM -2.41680750006269 0.0299008649349612 no 3192 0.00782864752617677 1072 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2640 pentamidine 10.38 µM -2.41902737872036 0.0297838910903798 no 3193 0.00778103442754647 1025 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1663 st014140 55.4 µM -2.42716727027175 0.0293582130062697 no 3194 0.00760861901927027 1078 4207120
SGTC_2004 4023728 41.89 µM -2.42855787077028 0.0292859988250342 no 3195 0.00757950282636425 1070 360084 YDR527W RBA50
SGTC_1458 k015-0034 6.33 µM -2.43191327515201 0.0291123592251448 no 3196 0.0075096515141672 1085 3598957
SGTC_3210 9128157 49.47 µM -2.43737739497386 0.0288314262822052 no 3197 0.00739711508621215 1063 17590849
SGTC_2250 alverine citrate 130 µM -2.44061675006946 0.0286659443429204 no 3198 0.00733110287026443 1056 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1152 3909-8331 15.9 µM -2.4417854106495 0.0286064377192057 no 3199 0.00730741545370524 1074 16001939
SGTC_3141 9094609 49.47 µM -2.44317099846213 0.0285360186065772 no 3200 0.00727941861175866 1064 25236309 YDL196W YDL196W
SGTC_2100 5377183 190 µM -2.45496651474665 0.0279423600083757 no 3201 0.00704488560873799 1066 2844202
SGTC_1100 amiodarone 5.07 µM -2.45518299474107 0.0279315616161444 no 3202 0.00704064433518859 1082 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_132 0417-1715 25.805 µM -2.45909712707996 0.0277369168345849 no 3203 0.00696434646668998 1090 6769098
SGTC_637 1181-0519 7.26 µM -2.46746932502667 0.0273243709376597 no 3204 0.00680359397413805 1068 6252091 YGR060W ERG25
SGTC_843 0310-0051 143 µM -2.46902401031434 0.0272483289394676 no 3205 0.0067741063813864 1089 2065037
SGTC_3343 9148379 18.9835 µM -2.47296651993829 0.027056285978948 no 3206 0.00669983477478871 1069 1955036
SGTC_3279 9140807 49.47 µM -2.47447734430365 0.026982992436098 no 3207 0.00667156416976432 1086 45595718
SGTC_656 4090-1979 187 µM -2.49130552774687 0.0261777642748178 no 3208 0.00636373105199817 1084 22330961
SGTC_2459 5811157 9.22 µM -2.49231303451538 0.0261301994747019 no 3209 0.00634570642566888 1078 2870684 YBR192W RIM2
SGTC_829 1635-0120 117 µM -2.49437889295688 0.0260328954744594 no 3210 0.00630888880783115 1063 285054
SGTC_988 1497-1057 103 µM -2.49623838251417 0.0259455710069668 no 3211 0.00627591093162982 1087 3533044
SGTC_476 mead acid 10 µM -2.49627650845412 0.0259437831215382 no 3212 0.00627523637136573 1087 5312531 An omega 9 fatty acid.
SGTC_403 arphamenine a 50 µM -2.49646876986295 0.0259347687470443 no 3213 0.00627183567831789 1077 5487158 An arginine aminopeptidase inhibitor.
SGTC_3319 9138450 16.7555 µM -2.49811989748313 0.0258574617548523 no 3214 0.00624269787812991 1072 2029690
SGTC_1416 3966-0321 25.3 µM -2.5031988006633 0.0256208716726098 no 3215 0.00615381947924448 1088 582530 YLR208W SEC13
SGTC_1407 3909-7909 12.3 µM -2.50502213252344 0.0255363788728337 no 3216 0.00612218655827215 1070 4411780
SGTC_2878 9043973 25.97 µM -2.51117882214273 0.0252528014126423 no 3217 0.0060164362923102 1086 6465167
SGTC_618 k072-0232 33.2 µM -2.51218363476375 0.0252067710859986 no 3218 0.00599933170399919 1060 5872756 YGL099W LSG1
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -2.52525287127382 0.0246144486420401 no 3219 0.0057807532365738 1084 16623 A steroid.
SGTC_3267 9137951 49.47 µM -2.53395988356066 0.0242263482868913 no 3220 0.00563908211890946 1093 16643986
SGTC_1239 0337-0584 35.4 µM -2.53563052702803 0.0241524728935827 no 3221 0.0056122544742685 1081 914301 YML130C ERO1
SGTC_2336 9001819 198.65 µM -2.53861426557396 0.0240210035706393 no 3222 0.0055646226652119 1064 2989602
SGTC_1906 st060206 94.7 µM -2.53924860842077 0.0239931308365388 no 3223 0.00555454254978829 1072 5133468
SGTC_2884 9058502 51.95 µM -2.54503379333609 0.0237401843773514 no 3224 0.0054633581574843 1083 6471554
SGTC_1930 st074634 34.3 µM -2.5459677270849 0.023699560801378 no 3225 0.00544876314136435 1076 684253 YOR116C RPO31
SGTC_2255 7941087 197.44 µM -2.57963151032552 0.0222738266935624 no 3226 0.00494528954911637 1089 935561
SGTC_1743 st037606 46.3785 µM -2.59823700013002 0.0215173739158685 no 3227 0.00468518975182357 1079 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_178 4092-0806 87.505 µM -2.60012208787536 0.021441956898987 no 3228 0.00465952997103852 1066 2169044
SGTC_1883 5-benzylidenerhodanine 20 µM -2.60643907265304 0.021190859306027 no 3229 0.00457445495035266 1077 1273210
SGTC_2696 st077691 74.316 µM -2.61198754645874 0.0209723658539035 no 3230 0.00450087665747924 1076 757133
SGTC_1844 rapamycin 4 nM -2.6270021643467 0.0203906446379957 no 3231 0.00430703930671697 1054 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_3016 9080866 49.47 µM -2.63592441595601 0.020051485179683 no 3232 0.00419542098486666 1084 17066299
SGTC_621 3584-0052 32.1 µM -2.66620593360995 0.0189358620958526 no 3233 0.0038356343016434 1080 2273927
SGTC_409 arachidonic acid 100 µM -2.6743661648049 0.0186444154099062 no 3234 0.00374353268798076 1084 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_233 rapamycin 362 pM -2.67598943554347 0.0185868971138796 no 3235 0.00372544968602198 1092 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1053 3366-3204 134 µM -2.68275400509751 0.0183488279507107 no 3236 0.00365093391829604 1088 3632071 YPR165W RHO1
SGTC_1313 1220-0047 237 µM -2.68470256949235 0.0182807348511188 no 3237 0.00362971884654641 1074 3528706
SGTC_1453 4237-0541 195 µM -2.70184669950989 0.0176908554740501 no 3238 0.00344777737606474 1070 739892
SGTC_1664 st014217 9.02 µM -2.70860883402522 0.0174626977975218 no 3239 0.00337829738966876 1078 3982782
SGTC_981 1488-1094 54.9 µM -2.71140683398634 0.017369029422492 no 3240 0.00334991830418063 1088 3449522
SGTC_1454 4239-0054 42.6 µM -2.71158262343577 0.0173631588894405 no 3241 0.00334814251201843 1086 1340767
SGTC_2404 5161160 200 µM -2.72102560000138 0.0170502890905232 no 3242 0.00325398607011076 1075 2831543
SGTC_820 1582-0060 59.9 µM -2.72398427277694 0.0169532575541761 no 3243 0.00322497889255428 1085 3848840
SGTC_1091 telmisartan 47.6 µM -2.74047289801808 0.0164211070022122 no 3244 0.00306754207440989 1088 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1464 k208-0027 110 µM -2.74388190499093 0.0163128877333025 no 3245 0.00303586882394965 1076 X1464
SGTC_1827 berberine 7.24 µM -2.75020836901411 0.0161136715873888 no 3246 0.00297786896119036 1052 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2816 7982706 58.44 µM -2.75188527469892 0.0160612177896485 no 3247 0.0029626637463871 1084 2981853
SGTC_2814 7977482 42.97 µM -2.76692347407636 0.0155973269205734 no 3248 0.00282940184063116 1079 6456762
SGTC_2248 tofa 1.1 µM -2.77588620860877 0.0153263543614732 no 3249 0.00275257361583339 1074 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_315 k915-0449 187 µM -2.77822656412012 0.0152562670464015 no 3250 0.00273282467153198 1082 20970215 YNL149C PGA2
SGTC_2805 7950783 58.44 µM -2.79111991487105 0.0148750623385541 no 3251 0.00262630041315022 1076 1178958 YDL195W SEC31
SGTC_1229 0139-0193 12.2 µM -2.79934135834757 0.0146362874069714 no 3252 0.00256034858642726 1085 3090752
SGTC_584 0986-0246 15.4 µM -2.83007741937342 0.0137726060168002 no 3253 0.00232683708588636 1089 53315 YDR232W HEM1
SGTC_1962 st076595 64.5 µM -2.83364435581457 0.0136752809725701 no 3254 0.00230102585994594 1079 279619
SGTC_690 glyoxal 20.3 µM -2.83946230151171 0.0135178096184692 no 3255 0.00225948171828648 1084 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_479 n-linoleoylglycine 10 µM -2.83978102037116 0.0135092284260196 no 3256 0.0022572256010385 1091 6433346 An anti-infammatory.
SGTC_2510 benzyl isothiocyanate 8.31 µM -2.84270826304003 0.0134306349727081 no 3257 0.0022365997617281 1080 2346 DNA damaging agent; causes G2/M arrest.
SGTC_3278 9139605 49.47 µM -2.84425264397253 0.0133893292512921 no 3258 0.00222578675166843 1084 7958859
SGTC_2930 9013230 14.89 µM -2.85593121668366 0.0130805127021398 no 3259 0.00214554042484355 1070 2995857
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -2.87760003448387 0.0125238089057129 no 3260 0.00200356419589444 1088 4174840
SGTC_1838 st055369 84.5 µM -2.90077519311143 0.0119512218705159 no 3261 0.00186120412151506 1086 676036
SGTC_2752 diclazuril 33.15 µM -2.90923532800925 0.0117479291089584 no 3262 0.00181157011234099 1085 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2817 7995342 71.43 µM -2.92137595058043 0.0114614423697009 no 3263 0.00174244511776056 1083 18879975
SGTC_2900 5328528 85.29 µM -2.9285255674036 0.0112955853948146 no 3264 0.00170286910760826 1084 795359
SGTC_1911 st060208 74.3 µM -2.9511466936996 0.010784485888988 no 3265 0.00158298257755631 1088 688783
SGTC_2881 9058953 51.95 µM -2.9652915516673 0.0104752312047902 no 3266 0.00151198098295757 1084 17122249
SGTC_3068 9116768 49.47 µM -2.9744006890147 0.0102801906798613 no 3267 0.00146780731753774 1083 41904888
SGTC_993 3909-8757 62.7 µM -2.97758893243178 0.0102126776448617 no 3268 0.00145262672768009 1087 4288324 YLR208W SEC13
SGTC_71 0417-1750 47.813 µM -2.99849355575325 0.00977951539725463 no 3269 0.00135658947067544 1079 6811472
SGTC_280 3448-3607 3.04 µM -2.99954617722072 0.00975813502793683 no 3270 0.00135191067508899 1074 626179
SGTC_3264 9137442 49.47 µM -3.00908298545905 0.00956628130941147 no 3271 0.00131018765687853 1085 17015726
SGTC_1406 3909-7906 11.9 µM -3.01859490752468 0.00937822089798701 no 3272 0.00126974922623073 1076 X1406
SGTC_41 0478-0632 82.643 µM -3.0386964049142 0.00899140253619077 no 3273 0.00118802083965316 1082 3750424
SGTC_2689 tacrolimus 100 µM -3.06490209696485 0.00850814948265013 no 3274 0.00108870630658881 1073 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1818 st052136 56.3 µM -3.08483424374568 0.00815599609462932 no 3275 0.00101832811687913 1080 674169
SGTC_804 1595-0054 20.9 µM -3.09552248069208 0.00797248745068201 no 3276 0.000982332395903331 1091 761523 Stimulates phospholipase C.
SGTC_580 1123-0028 41 µM -3.12060508482125 0.00755602877443633 no 3277 0.000902399454751969 1094 1677248 YPR107C YTH1
SGTC_1209 2323-2347 50.3 µM -3.12729540176618 0.00744823461824484 no 3278 0.000882112830417044 1078 5412760
SGTC_2600 tangeritin 87.95 µM -3.13814611260557 0.00727628769410066 no 3279 0.000850100507948139 1087 68077 A bioactive flavone.
SGTC_1652 st011932 78 µM -3.15288597162837 0.0070483212107034 no 3280 0.000808324717449493 1090 1551076
SGTC_2534 helenine 20.12 µM -3.18763424267884 0.00653567820321796 no 3281 0.000717209279393335 1084 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3089 9117425 49.47 µM -3.20101732398819 0.00634720974935731 no 3282 0.000684716491787433 1091 9401657
SGTC_2396 5342950 42.78 µM -3.21333496668452 0.00617801337607754 no 3283 0.000656015874357849 1074 1886677
SGTC_1978 st071761 42 µM -3.22466163951409 0.00602596767988406 no 3284 0.00063060817826689 1090 5147680
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -3.22619051018366 0.00600570074837951 no 3285 0.000627249121139185 1092 4213774
SGTC_3101 9120531 49.47 µM -3.24332369914863 0.00578267985580771 no 3286 0.000590719510335164 1091 24824904
SGTC_1404 3909-7820 48.3 µM -3.26199727933961 0.00554800583926643 no 3287 0.000553151026665753 1075 23741373
SGTC_2997 9067075 71.4286 µM -3.2947030598173 0.00515730640261246 no 3288 0.000492628656801629 1083 27209819
SGTC_2845 9003024 42.97 µM -3.29481593052441 0.00515600158032688 no 3289 0.00049243084033506 1090 2990173
SGTC_2139 5578692 56.4705 µM -3.29518915215591 0.00515168910797958 no 3290 0.000491777258102786 1082 650991 YMR113W FOL3
SGTC_1800 st050079 29.0735 µM -3.31039938433569 0.00497864794158087 no 3291 0.000465814694512281 1082 3645560
SGTC_2853 9015042 58.44 µM -3.37371384479113 0.00431268726465098 no 3292 0.000370807089917749 1091 6457456
SGTC_586 0957-0265 8.15 µM -3.39079591195972 0.00414722171477739 no 3293 0.000348449880310783 1080 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3219 9131112 49.47 µM -3.393320218349 0.00412325778313532 no 3294 0.0003452543377015 1070 17612988 YMR079W SEC14
SGTC_1801 st050089 28.441 µM -3.40160416068835 0.00404548414697006 no 3295 0.000334957969729092 1094 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1941 st076221 61.8 µM -3.40748614570995 0.00399106123215566 no 3296 0.000327821184286423 1080 2828568
SGTC_810 3825-7150 143 µM -3.40941097539133 0.00397339470493251 no 3297 0.000325516612054599 1085 22330411 YGL099W LSG1
SGTC_1896 st058441 89 µM -3.43715231762673 0.00372644278241921 no 3298 0.000293932456047914 1091 688759
SGTC_2584 androsterone 48.74 µM -3.43785452248837 0.0037203744807923 no 3299 0.000293171308463644 1079 2754130 A steroid.
SGTC_2928 9011484 9.79 µM -3.45166346579365 0.00360282775153307 no 3300 0.000278571078729227 1084 2994751
SGTC_1989 st071868 50.2 µM -3.48395211353594 0.00334088375887941 no 3301 0.000247033938673774 1092 16414057
SGTC_110 0850-0284 111.64 µM -3.48620113791032 0.00332329264946513 no 3302 0.00024496624036188 1091 3906265
SGTC_1548 st061468 90.8 µM -3.49274573915878 0.00327257576341642 no 3303 0.000239040742412746 1094 390799
SGTC_1581 himbacine 57.9 µM -3.49761177153658 0.00323531917070758 no 3304 0.000234721977575965 1092 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2519 cryptotanshinone 88.04 µM -3.53764379058829 0.00294300682275161 no 3305 0.000201857149334473 1084 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2659 sanguinarine 24.21 µM -3.5440264771436 0.00289866711736425 no 3306 0.000197032834573548 1082 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3224 9130643 49.47 µM -3.5755299380302 0.00268851645489406 no 3307 0.000174759586708937 1095 17644395
SGTC_2066 5222451 176 µM -3.61355276872773 0.00245325532893457 no 3308 0.00015101492588687 1068 2281147
SGTC_1552 6-methylflavone 10.6 µM -3.62609247674441 0.00237985212183866 no 3309 0.000143871172073619 1095 689013
SGTC_1643 st009866 20.2 µM -3.62930725425153 0.00236135685255164 no 3310 0.000142091414828683 1088 3156273 YOR207C RET1
SGTC_1907 st060210 83.7 µM -3.69581877901351 0.00200676233023273 no 3311 0.000109589638140904 1086 688793
SGTC_922 1866-0035 480 µM -3.7130714946158 0.00192304763191198 no 3312 0.00010237950653951 1086 3156169
SGTC_2186 6124449 200 µM -3.71412159730831 0.001918056186616 no 3313 0.00010195536767123 1091 3834182 YLR033W RSC58
SGTC_2766 oltipraz 83.91 µM -3.76551048211174 0.00168770823678978 no 3314 8.31045750190382e-05 1058 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2795 7780010 54.55 µM -3.76629070007365 0.00168441386456904 no 3315 8.2845430273644e-05 1091 953673
SGTC_2776 terbinafine 19.92 µM -3.76837179349934 0.00167565532796737 no 3316 8.2157920885459e-05 1090 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2671 danthron 100 µM -3.77046553033374 0.00166688545048293 no 3317 8.14716541759824e-05 1094 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_490 phenamil 164 µM -3.78925998165434 0.00159001428528506 no 3318 7.55483599318324e-05 1047 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1707 st032323 6.317 µM -3.80107679362132 0.0015433513451253 no 3319 7.20343196869652e-05 1091 3132057 YMR211W DML1
SGTC_2890 9046729 58.44 µM -3.86612144237164 0.00130812296103961 no 3320 5.52899450940654e-05 1093 903329
SGTC_394 menadione 8.33 µM -3.89804570636994 0.00120509910110681 no 3321 4.84860581566801e-05 1088 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1803 st050068 52.4 µM -3.9087954870528 0.00117211574953383 no 3322 4.63787224146242e-05 1091 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3307 9126885 69.2785 µM -3.96061760244949 0.00102440760617132 no 3323 3.73780824607092e-05 1094 24824909
SGTC_3277 9138724 49.47 µM -3.97155206686344 0.000995510371350387 yes 3324 3.57029448108728e-05 1094 15943418
SGTC_2257 7960413 200 µM -3.97798964025834 0.000978849218253209 yes 3325 3.4750199539564e-05 1095 2974689 YIL048W NEO1
SGTC_2772 vinpocetine 57.06 µM -3.98084872485867 0.000971532008247514 yes 3326 3.4334821075468e-05 1093 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2471 5466956 24.79 µM -4.01157727437209 0.000895998580475565 yes 3327 3.01572139961948e-05 1094 724419
SGTC_2092 5303694 80.6725 µM -4.06587400825424 0.000775590106970008 yes 3328 2.39263920948156e-05 1095 1963699
SGTC_3222 9128301 49.47 µM -4.08107946094047 0.000744647648160594 yes 3329 2.24135127331858e-05 1082 4911358
SGTC_1871 st057448 67.3 µM -4.15918919617453 0.000602873998724644 yes 3330 1.59689639145846e-05 1094 691747
SGTC_2179 6298986 200 µM -4.19023837197297 0.000553794575002452 yes 3331 1.39330777155525e-05 1081 738374
SGTC_1786 berberine 21.6 µM -4.20238860635038 0.000535615284773311 yes 3332 1.32056612290228e-05 1070 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2338 7999974 200 µM -4.22291737706187 0.000506149332757425 yes 3333 1.20580122080306e-05 1088 315925
SGTC_2168 5727979 200 µM -4.2520658338267 0.000466882547384037 yes 3334 1.05903785579988e-05 1095 695210
SGTC_1269 0831-0796 3.05 µM -4.35838795734873 0.000346342441285941 yes 3335 6.55119853331633e-06 1088 927758
SGTC_1525 8-methoxypsoralen 92.5 µM -4.55470486081328 0.000196188888125907 yes 3336 2.62295895625202e-06 1093 4114 Related to psoralen; DNA damaging agent.
SGTC_793 0488-0545 106 µM -4.56697798142571 0.000189202175114725 yes 3337 2.47402981678647e-06 1095 292548
SGTC_1547 harmine 94.2 µM -4.67137720956063 0.00013850135607204 yes 3338 1.49593465401668e-06 1094 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2949 9072542 2.23 µM -4.72432825574479 0.000117952611978876 yes 3339 1.15438617234451e-06 1095 16457352
SGTC_2645 abamectin 100 µM -4.93817135143978 6.06640440082298e-05 yes 3340 3.94292692690668e-07 1081 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2041 5107442 45.335 µM -4.98188035174783 5.27839527501935e-05 yes 3341 3.14846836708448e-07 1094 793005
SGTC_2739 tacrine 100.86 µM -5.0628093195145 4.06774576728119e-05 yes 3342 2.06561502896271e-07 1075 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2036 5160441 105 µM -5.1169003757833 3.4104734522954e-05 yes 3343 1.55298783626348e-07 1094 134534 YIL048W NEO1
SGTC_2799 7812892 81.82 µM -5.27064738368564 2.04766609571894e-05 yes 3344 6.79717073177183e-08 1095 20205235
SGTC_1556 plumbagin 1.48 µM -5.30690537155955 1.81194903652374e-05 yes 3345 5.57510125456249e-08 1093 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -5.49590519516666 9.46101900602334e-06 yes 3346 1.94355653403568e-08 1094 688669
SGTC_2948 9070189 9.45 µM -5.57518905746699 7.15942820096571e-06 yes 3347 1.23630593590276e-08 1093 6473636 YDL196W YDL196W
SGTC_2848 9016370 25.97 µM -5.77156710838213 3.53348745218103e-06 yes 3348 3.9268834314055e-09 1095 7894410
SGTC_799 1310-0557 151 µM -7.47498216448741 3.002535303175e-09 yes 3349 3.86071629193318e-14 1095 5354492
SGTC_2858 9025781 8.96 µM -8.227834294114 7.65758914342474e-11 yes 3350 9.53142697553873e-17 1095 4894980 YPL153C RAD53