SGTCid condition conc unit GAT3|YLR013W.score GAT3|YLR013W.strain.pval GAT3|YLR013W.strain.significant GAT3|YLR013W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1836 st055642 81 µM 6.21813932847541 6.65170226748436e-11 yes 1 2.51542379794137e-10 2 8571
SGTC_2858 9025781 8.96 µM 5.72975772083099 1.62185508438232e-09 yes 2 5.02870890728636e-09 50 4894980 YPL153C RAD53
SGTC_2288 7946289 167.31 µM 5.07141391275371 8.10952906049994e-08 yes 3 1.97435441230085e-07 10 1246052
SGTC_2420 aureobasidin a 50 nM 4.55472613935694 1.27561810584441e-06 yes 4 2.62269347224358e-06 27 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1020 4335-0961 93.3 µM 4.39154107807951 2.87625173954441e-06 yes 5 5.62750328519137e-06 7 669075
SGTC_2826 7992541 19.48 µM 4.30905283171097 4.29332276886528e-06 yes 6 8.19776011879299e-06 14 2985066
SGTC_2635 hydroquinidine 100 µM 4.16431795496331 8.5252855901835e-06 yes 7 1.56142338289112e-05 20 442912 An experimental heart treatment.
SGTC_2703 st077852 53.4 µM 4.02373349634574 1.62614894334334e-05 yes 8 2.86413679778444e-05 20 6281836
SGTC_1251 0490-5699 265 µM 3.79031578260386 4.54408954306258e-05 yes 9 7.52279419866271e-05 39 3883818
SGTC_762 1165-0429 115 µM 3.73489901222123 5.75257308027498e-05 yes 10 9.38952646743585e-05 25 5967793
SGTC_2415 st077333 57.7 µM 3.66277489081207 7.78260183734547e-05 yes 11 0.00012474889050692 63 2766255
SGTC_3041 9091929 49.47 µM 3.6007071328149 0.00010051952053423 yes 12 0.000158676444544484 32 25236887
SGTC_2399 5884133 200 µM 3.56827902461921 0.000114718948884943 yes 13 0.00017966686339351 89 722445
SGTC_135 0933-0004 26.348 µM 3.52929955072628 0.000134276918320998 yes 14 0.000208330607810397 36 21230617 YGL099W LSG1
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 3.50025525158522 0.000150837142334415 yes 15 0.0002324064248689 63 688788
SGTC_1063 disulfiram 1.84 µM 3.4662290493711 0.000172666301989971 yes 16 0.000263906712046163 41 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1244 0416-0015 52.5 µM 3.45599476422366 0.000179789203581967 yes 17 0.000274132985300887 59 96201
SGTC_2316 5844804 197.44 µM 3.45230764377708 0.000182422031259267 yes 18 0.000277906807954904 57 776813
SGTC_3204 9114183 49.47 µM 3.44806700402944 0.000185494663834521 yes 19 0.000282306976177574 53 17027248
SGTC_617 3770-0098 35 µM 3.44679821427752 0.000186423350304653 yes 20 0.000283636053785076 25 5962639
SGTC_2951 9072950 58.06 µM 3.40234034086078 0.000221846117016766 yes 21 0.000334056898531336 41 16488155
SGTC_2226 7298446 200 µM 3.35501230934384 0.000266397308907986 yes 22 0.000396807265397816 8 3283010
SGTC_996 3970-0799 1.8 µM 3.28078202340059 0.000353355746443416 yes 23 0.000517598568023253 132 6615648 YGL040C HEM2
SGTC_775 4577-0580 57.3 µM 3.27480554817073 0.000361397345699658 yes 24 0.000528673632789574 25 2006902
SGTC_1209 2323-2347 50.3 µM 3.2098666346189 0.000460436264261269 yes 25 0.000663982853310944 36 5412760
SGTC_985 1493-0307 8.71 µM 3.203561263936 0.000471286205440763 yes 26 0.000678695783428657 39 3278274
SGTC_1741 st038134 10.228 µM 3.18755850477135 0.000499895187570414 yes 27 0.000717397141876289 68 1272587
SGTC_1074 carmofur 3.8 µM 3.15869100614397 0.000555605688308383 yes 28 0.000792397102488573 57 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_76 0433-0009 400.328 µM 3.13212468388997 0.000611893997384466 yes 29 0.000867730784112741 32 2841569
SGTC_769 0302-0231 76 µM 3.12746395100411 0.00062229608026912 yes 30 0.000881607206646449 101 571869 YER009W NTF2
SGTC_2241 6772625 37.8075 µM 3.12088308793535 0.000637261850579906 yes 31 0.000901548016259643 58 2285411
SGTC_1412 3909-8563 178 µM 3.04920484870031 0.000823216665754024 yes 32 0.00114723984434995 42 23767530
SGTC_2056 5235370 200 µM 3.02278199444216 0.000903529849113896 yes 33 0.00125231302513952 83 5511916
SGTC_2825 7998094 58.44 µM 2.96324132274123 0.00111156496721416 no 34 0.00152208902968564 71 2987815
SGTC_110 0850-0284 111.64 µM 2.94466859320831 0.00118493022858789 no 35 0.00161650376797581 34 3906265
SGTC_1196 1588-0294 184 µM 2.94307304222354 0.00119143529759335 no 36 0.00162485867459096 53 6144269
SGTC_3221 9128209 49.47 µM 2.90573427879453 0.00135331432582827 no 37 0.00183196224781679 61 16460723
SGTC_2206 7254556 146.969 µM 2.88866384719548 0.00143381490216237 no 38 0.00193441206912532 23 4398905
SGTC_1909 st060837 51.5 µM 2.87999983461594 0.00147632360394143 no 39 0.00198837689792656 102 678937
SGTC_652 0437-0092 114 µM 2.86936255691992 0.00153008530688812 no 40 0.00205650021835959 52 3091274
SGTC_1744 st037937 38.9 µM 2.85374438688209 0.0016122604796724 no 41 0.00216036404179864 86 1016152
SGTC_1189 1431-2119 7.28 µM 2.82043034919545 0.00180113324007044 no 42 0.00239796417934924 107 3107275
SGTC_585 0kpi-0023 191 µM 2.80996532969402 0.00186449147876449 no 43 0.00247734185207886 64 64601
SGTC_2104 5389443 200 µM 2.78239358314795 0.00204123614940484 no 44 0.00269797790045135 79 2244536
SGTC_1022 4477-0945 21.3 µM 2.78129139620407 0.00204860770530261 no 45 0.00270715571954654 84 4648966
SGTC_82 0054-0107 293.755 µM 2.76303221131035 0.00217429432021426 no 46 0.00286335573058776 46 3104697
SGTC_2340 7987427 183.45 µM 2.72946966058675 0.00242369567984443 no 47 0.00317181429937362 103 2239331
SGTC_3254 9136651 49.47 µM 2.69705088251331 0.00268888548779572 no 48 0.00349782900052936 77 16454030
SGTC_3295 9122362 53.5725 µM 2.68382415317609 0.00280440879236019 no 49 0.00363926890633783 76 4730473
SGTC_1574 spiramycin 23.7 µM 2.67095356323678 0.00292110103286959 no 50 0.00378180548089293 102 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2412 st077135 33.4 µM 2.67016512003508 0.00292838981068474 no 51 0.003790697715657 112 13258915
SGTC_1545 lovastatin 49.4 µM 2.66828171233292 0.00294586740800394 no 52 0.00381201511419063 120 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_668 1682-0499 62.6 µM 2.63067274669963 0.00331513183729397 no 53 0.00426080245164256 102 682214
SGTC_851 0394-0702 453 µM 2.62949594629058 0.00332732994409731 no 54 0.00427557756876433 82 762646
SGTC_1620 st003704 16.5 µM 2.60368437324635 0.00360522925751532 no 55 0.00461138234261932 79 2834414
SGTC_2163 5671233 125 µM 2.60061758622033 0.00363959567213332 no 56 0.00465280610095082 121 701023
SGTC_980 1473-0395 201 µM 2.60012036951762 0.00364519509181258 no 57 0.00465955330408305 69 768876
SGTC_2186 6124449 200 µM 2.59276632026099 0.00372892035962082 no 58 0.00476037179121748 100 3834182 YLR033W RSC58
SGTC_1606 st000094 49.2 µM 2.56697749380381 0.00403632172051184 no 59 0.00512946353748024 102 1242210
SGTC_3148 9097893 49.47 µM 2.56209364077103 0.0040970287419722 no 60 0.00520216310346021 124 17174100
SGTC_71 0417-1750 47.813 µM 2.56194680116868 0.00409886656677953 no 61 0.00520436304000363 148 6811472
SGTC_2032 5185112 25.99 µM 2.56016821972902 0.00412118571469526 no 62 0.00523107538439027 82 5718189
SGTC_737 1950-0117 57.9 µM 2.55070952599237 0.00424171838645949 no 63 0.00537519415211645 103 5393513
SGTC_653 0203-0016 55.2 µM 2.5501796063765 0.00424856350300363 no 64 0.00538337178815073 98 295302
SGTC_821 1114-0266 29.2 µM 2.5452844063787 0.00431226471429057 no 65 0.0054594383045122 105 3123235
SGTC_2231 micatex 6.853 µM 2.54370865770328 0.00433295081156275 no 66 0.00548412628536793 78 20737 An antifungal of unknown mechanism.
SGTC_261 5-fluorouridine 15.376 µM 2.51484951417065 0.00472782150101636 no 67 0.00595416006101149 119 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2950 9072895 21.46 µM 2.51347884441412 0.00474735007240671 no 68 0.00597734738839245 164 17332245
SGTC_1097 itavastatin 7.23 µM 2.49834389662142 0.00496781576425674 no 69 0.00623875416626716 122 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_470 aa-861 153 µM 2.49574953337921 0.00500650945817136 no 70 0.00628456580471031 169 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2215 7188065 200 µM 2.47786068311979 0.00528069835653846 no 71 0.00660863714371413 75 940217
SGTC_2683 piperine 63.03 µM 2.47441084422209 0.00533508587106137 no 72 0.00667280630002039 90 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_795 0685-0265 78 µM 2.44275205946889 0.00585792183694232 no 73 0.00728787359749718 142 302754
SGTC_1496 4469-0713 57.4 µM 2.43957786998292 0.00591277069120709 no 74 0.00735221658507693 111 746691
SGTC_552 k242-0005 476 µM 2.42529740744929 0.00616520562819585 no 75 0.00764792516347754 110 4088318
SGTC_75 0159-0059 199.013 µM 2.40688525207579 0.00650474017136854 no 76 0.00804461213406057 129 5377270
SGTC_3217 9129673 49.47 µM 2.4001142270011 0.00663370207171732 no 77 0.0081949782151725 166 17248312
SGTC_1685 st024049 53.0905 µM 2.36383350290612 0.00736394573805844 no 78 0.00904346956294175 109 1941139
SGTC_80 0159-0065 512.242 µM 2.35164250043561 0.00762475607772242 no 79 0.00934536445330064 62 1548079
SGTC_3128 9127691 49.47 µM 2.3393557655908 0.00789580952364015 no 80 0.00965851441314032 120 41316314
SGTC_2129 girgensonine 121.053 µM 2.32481269933552 0.00822756198835757 no 81 0.0100409888276346 173 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1115 galangin 695.678 nM 2.32458118152815 0.00823294085843547 no 82 0.0100471830088422 144 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_292 k038-0015 474 µM 2.3219337974337 0.00829466768016558 no 83 0.0101182503125124 112 46368540
SGTC_3075 9116269 49.47 µM 2.31275745901485 0.00851178169707354 no 84 0.0103679889592604 130 17015205 YNL244C SUI1
SGTC_278 4092-0821 23.9 µM 2.30099741894123 0.00879730668026566 no 85 0.0106958884857411 165 877900
SGTC_2344 7990960 76.95 µM 2.29464705052512 0.00895495270112944 no 86 0.0108766797727905 146 140813
SGTC_657 3534-0529 86.7 µM 2.28055122845236 0.00931374735549887 no 87 0.0112875080562839 136 1049549
SGTC_3322 9139058 2.11 µM 2.27974207409714 0.00933472002999218 no 88 0.0113114951734648 160 4908926 YPR165W RHO1
SGTC_2142 5622915 118.518 µM 2.25612707910108 0.00996527446472381 no 89 0.0120313368471629 128 5322196
SGTC_2334 9017922 200 µM 2.25474567859573 0.0100032846550506 no 90 0.0120746483513232 132 3163164
SGTC_1415 3966-0071 78.1 µM 2.25083309914045 0.0101116295801773 no 91 0.0121980551486269 116 2893185
SGTC_913 3487-1245 167 µM 2.24161996956202 0.0103708068849172 no 92 0.0124929721090496 187 4016153
SGTC_1604 st002052 72.4 µM 2.23825366342468 0.0104669398459802 no 93 0.0126022589739492 150 6254834 YHR062C RPP1
SGTC_3174 9107204 49.47 µM 2.23066327447356 0.0106865557306132 no 94 0.0128517210344134 174 3938802
SGTC_511 blebbistatin 171 µM 2.2118918197453 0.0112469890911545 no 95 0.0134870703073148 155 3476986 A myosin inhibitor.
SGTC_1399 3562-5772 25 µM 2.21156144182329 0.0112570772953546 no 96 0.0134984910513865 125 23847490
SGTC_3011 9081274 71.4286 µM 2.21059177501589 0.0112867318408531 no 97 0.0135320594212323 184 6625322
SGTC_2907 7721985 69.9 µM 2.21006266856563 0.0113029416950979 no 98 0.0135504066389365 178 3267881
SGTC_1285 0929-0069 65.5 µM 2.20794411006419 0.0113680493137643 no 99 0.0136240847231074 173 1206237
SGTC_3071 9117417 49.47 µM 2.20789071373772 0.0113696944931793 no 100 0.013625946169413 120 45595590 YGL055W OLE1
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 2.20615040952845 0.011423427893361 no 101 0.013686735074208 181 5377381
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 2.1928164531929 0.0118424954972496 no 102 0.0141603030121624 201 23847180
SGTC_2805 7950783 58.44 µM 2.17596552549165 0.0123911261519223 no 103 0.0147789192332398 198 1178958 YDL195W SEC31
SGTC_2656 pseudo-anisatin 100 µM 2.17244425175514 0.0125085122332252 no 104 0.0149110851401135 89 6708809 A neurotoxin.
SGTC_2913 7966556 36.57 µM 2.17236752351968 0.0125110807475635 no 105 0.0149139762994221 138 2976516
SGTC_2931 9014674 55.67 µM 2.17182162401096 0.0125293681800607 no 106 0.0149345599891854 185 2996810
SGTC_354 2783-3500 4.88 µM 2.17157911718154 0.012537499490606 no 107 0.0149437117847683 215 6740761
SGTC_1240 0356-0016 42.1 µM 2.14957259354123 0.0132946573981296 no 108 0.0157945191028937 194 4305613
SGTC_761 k216-0224 480 µM 2.13107873245982 0.0139611890186243 no 109 0.0165413282414691 190 1340404
SGTC_2816 7982706 58.44 µM 2.1184973591691 0.0144309252042363 no 110 0.0170664841655636 220 2981853
SGTC_2880 9042983 58.44 µM 2.11257543810976 0.0146566941901559 no 111 0.0173185614177285 190 6464714
SGTC_2989 9073649 71.4286 µM 2.11123400245613 0.014708255556161 no 112 0.0173761017800622 262 21367202
SGTC_3306 9127676 59.7925 µM 2.10886166766868 0.0147998240987743 no 113 0.0174782618845807 189 41905287
SGTC_244 nsc-207895 1.295 µM 2.10338992878903 0.0150128962820805 no 114 0.0177158490462641 117 42640
SGTC_1745 st081495 74 µM 2.10266737806506 0.0150412288865586 no 115 0.0177474277956441 293 13842402 YBL026W LSM2
SGTC_2235 salicylic acid 500 µM 2.10193910961752 0.0150698321831279 no 116 0.0177793050206353 120 338 A COX inhibitor and kinase inhibitor.
SGTC_643 k048-0106 28.4 µM 2.08906669226791 0.0155831744595737 no 117 0.0183508600606352 166 6763920
SGTC_1019 4262-0212 3.4 µM 2.08625211451576 0.0156973957189724 no 118 0.0184778958957736 272 4677213
SGTC_2284 7945075 39.21 µM 2.08335717524719 0.0158156267546921 no 119 0.0186093393618525 229 1245402
SGTC_1484 3473-2379 286 µM 2.07776817416665 0.0160460463942895 no 120 0.0188653582260868 203 671917
SGTC_1192 1488-0095 21.4 µM 2.07292555846151 0.0162480152054052 no 121 0.0190896040053313 181 915875
SGTC_126 0417-1624 672.48 µM 2.0716590202833 0.0163011960041314 no 122 0.0191486257915883 270 41912 YDL195W SEC31
SGTC_1686 st019653 115.5 µM 2.06935103034313 0.0163984898375077 no 123 0.0192565791141677 161 97252
SGTC_2013 4024628 200 µM 2.06055018343452 0.0167740675916632 no 124 0.019672986773885 230 5230760
SGTC_594 1487-1584 10.8 µM 2.05987370945098 0.0168032383536372 no 125 0.0197053078292249 195 5013332
SGTC_1300 1094-0077 113 µM 2.05329442517397 0.0170892190166852 no 126 0.0200220156109726 186 5532636
SGTC_3116 9124943 49.47 µM 2.0298791733404 0.0181409928166093 no 127 0.021184411278076 199 41905195 YPL160W CDC60
SGTC_978 1416-0512 87.4 µM 2.02727031589418 0.0182615245495695 no 128 0.0213173877550022 240 6814003
SGTC_773 4358-1457 44.6 µM 2.01720817008723 0.018732816873014 no 129 0.0218368969155337 270 1186886
SGTC_1203 3992-3522 103 µM 1.99451949235015 0.0198336172893794 no 130 0.023047655971747 249 5322312
SGTC_554 4483-2211 187 µM 1.99115173832023 0.0200016022796027 no 131 0.0232321039231231 213 747107
SGTC_2943 9068529 45.32 µM 1.99070963753302 0.0200237438211401 no 132 0.0232564092823496 234 3270634
SGTC_2187 6125751 200 µM 1.97479689493937 0.0208346508677802 no 133 0.024145600783506 218 874498
SGTC_2831 7999036 19.48 µM 1.97384044900424 0.0208842642615376 no 134 0.0241999439422538 276 2988270
SGTC_1879 gemcitabine 100 µM 1.96802759262886 0.0211879482658083 no 135 0.0245324314971968 217 60750 A nucleoside analog which inhibits DNA replication.
SGTC_680 0417-1641 114 µM 1.96034502304545 0.0215950363418154 no 136 0.0249777384922161 208 2835990
SGTC_880 0833-0487 87.2 µM 1.95723131116397 0.0217618995312992 no 137 0.0251601395533966 226 76075
SGTC_2811 7967822 32.47 µM 1.94885103872081 0.0222164153823357 no 138 0.0256566082784786 231 2232244
SGTC_3080 9117754 49.47 µM 1.94255219272415 0.02256329229813 no 139 0.0260351439844134 251 9550191
SGTC_1624 st003710 6.25 µM 1.94201948767544 0.0225928366028521 no 140 0.0260673705860257 289 24207033
SGTC_2326 6164455 177.58 µM 1.93530751615371 0.0229678912489925 no 141 0.0264762852803847 227 2888790
SGTC_1605 st000082 49.1 µM 1.92717957000591 0.0234290757501482 no 142 0.0269786275571567 223 1114022
SGTC_1100 amiodarone 5.07 µM 1.9134545633432 0.0242255227376754 no 143 0.027844942480346 261 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1428 4049-0204 61.7 µM 1.90503661582799 0.0247251661518419 no 144 0.0283876558036307 233 X1428
SGTC_1892 st058411 7.36 µM 1.90281059049487 0.0248587268843223 no 145 0.0285326324076399 287 3934738
SGTC_2639 lactacystin 53 µM 1.90207424253256 0.024903040463746 no 146 0.028580724642843 258 3870 A proteasome inhibitor.
SGTC_1524 corynanthine 62.1 µM 1.89282960495697 0.0254650434931242 no 147 0.0291902665881703 240 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1578 josamycin 24.2 µM 1.8711410535836 0.0268253384471333 no 148 0.0306627662838283 241 5282165 A P450 substrate.
SGTC_2875 9039966 71.43 µM 1.8696347670772 0.0269220236426027 no 149 0.0307672769222174 193 6463691
SGTC_1045 1348-1485 165 µM 1.86779862456933 0.0270402748290217 no 150 0.0308950726303997 312 6810614
SGTC_744 1594-0068 283 µM 1.85920304188881 0.0275996263690067 no 151 0.031499181910883 314 668392
SGTC_2837 9008476 45.46 µM 1.85852762673659 0.0276439842873101 no 152 0.0315470619592112 305 2992805
SGTC_2292 7671323 168.05 µM 1.85044205289886 0.0281796332766554 no 153 0.0321249313325771 316 937504
SGTC_2669 eugenol 100 µM 1.84767487877832 0.0283649247617014 no 154 0.032324695106665 192 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_790 1575-0012 79.1 µM 1.84065950185887 0.028839225813397 no 155 0.0328357360949779 282 378741 YLR208W SEC13
SGTC_1011 4112-3381 17.4 µM 1.83185558059797 0.0294437585222223 no 156 0.0334864699585461 294 2877139
SGTC_184 1494-0393 24.714 µM 1.81764613657279 0.0304416397983617 no 157 0.0345591176111866 327 3090647
SGTC_1471 k673-0312 37 µM 1.81753340518918 0.03044966719663 no 158 0.0345677390590235 242 24099884
SGTC_2842 9000675 19.48 µM 1.81744104335228 0.0304562454231933 no 159 0.0345748040054639 268 2989072
SGTC_1454 4239-0054 42.6 µM 1.81686127215919 0.0304975649823261 no 160 0.0346191789884775 326 1340767
SGTC_3229 9132204 49.47 µM 1.80495709118709 0.0313562775241655 no 161 0.0355406984100326 183 17682924
SGTC_3263 9137018 49.47 µM 1.80298337674757 0.0315005663003426 no 162 0.0356954126927974 287 43844957
SGTC_153 4077-0274 519.67 µM 1.80209566364526 0.0315656414490399 no 163 0.0357651779255459 251 3121976
SGTC_385 1494-0393 12.4 µM 1.79273817609564 0.0322583886544999 no 164 0.0365073995788424 291 3090647
SGTC_1449 4112-4002 201 µM 1.79130578886701 0.032365529388584 no 165 0.0366221188455733 277 2059539
SGTC_468 gf-109203x 121 µM 1.79020697094196 0.0324479184419136 no 166 0.0367103224332782 166 2396 A protein kinase C inhibitor.
SGTC_347 4534-1311 26.2 µM 1.77923766222163 0.0332799172779944 no 167 0.0376004030904734 279 2862016
SGTC_5 0352-0601 109.883 µM 1.77540482553187 0.0335747403203572 no 168 0.0379155339073819 219 762456
SGTC_1839 st053978 48 µM 1.76143003221253 0.0346679476508214 no 169 0.0390828228362335 286 3788398
SGTC_1375 2910-0797 186 µM 1.75494670525843 0.0351849569509168 no 170 0.0396342121045595 306 742508
SGTC_1913 st060213 96.1 µM 1.75011663308814 0.0355742261588027 no 171 0.0400490951005865 347 688959
SGTC_1874 staurosporine 7.6 µM 1.74899156776723 0.0356654034981289 no 172 0.0401462384946586 322 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1679 SEC14.276 6.7 µM 1.74769696412852 0.0357705574435717 no 173 0.0402582573973491 359 1005053 YMR079W SEC14
SGTC_1573 oleylamine 1.06 µM 1.74670597041051 0.0358512222831867 no 174 0.0403441771079436 324 5356789 An amine of the fatty acid oleic acid.
SGTC_2174 5790901 200 µM 1.7463745878368 0.0358782293675891 no 175 0.0403729413644447 326 786020
SGTC_100 0086-0128 49.5915 µM 1.74107714119657 0.0363122292049338 no 176 0.0408350287987809 378 93297
SGTC_577 r071-0003 38.6 µM 1.73957637151734 0.0364359598016035 no 177 0.0409667156049411 436 4568517 YMR134W ERG29
SGTC_2106 5357045 167.29 µM 1.73953913122701 0.0364390344498619 no 178 0.0409699876727093 318 668842
SGTC_1409 3909-8004 61.9 µM 1.73722198213193 0.0366307618858341 no 179 0.0411739981414562 341 2119279
SGTC_2857 9024691 58.44 µM 1.73612499155337 0.036721817368397 no 180 0.0412708681575722 295 16478292
SGTC_932 2857-0803 154 µM 1.73240004389577 0.0370323883639044 no 181 0.0416011800928383 316 674898
SGTC_2606 farnesol 9.78 µM 1.72947862981743 0.0372774633789024 no 182 0.0418617339888187 325 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_266 formosanin C 406 nM 1.72625088895962 0.0375497749674078 no 183 0.0421511432346636 351 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1215 3852-0577 11.2 µM 1.72397156214346 0.0377430494689751 no 184 0.0423564885334681 338 2884876
SGTC_2179 6298986 200 µM 1.71801907124238 0.0382516197414697 no 185 0.04289656836934 269 738374
SGTC_192 3455-0609 60.9 µM 1.71282353853511 0.0387000712321503 no 186 0.043372504166739 295 3769639
SGTC_2083 5306046 65.942 µM 1.71123909128834 0.0388376817027858 no 187 0.0435184925340312 352 539837
SGTC_127 0180-0333 59.125 µM 1.70884976041575 0.0390459503335083 no 188 0.0437393913148868 419 771601
SGTC_2381 9035592 200 µM 1.70574810936364 0.0393176644781712 no 189 0.0440274940840817 265 4749657
SGTC_3100 9120536 49.47 µM 1.69096509315711 0.0406339179141176 no 190 0.0454217348609842 216 16421196
SGTC_1163 k060-0048 49.9 µM 1.69046810440992 0.040678782859424 no 191 0.0454692176620001 369 6809982
SGTC_407 eburnamonine 100 µM 1.68653984740183 0.0410348169688183 no 192 0.0458459334087745 285 3195
SGTC_2285 7945142 200 µM 1.68641449663715 0.0410462195007905 no 193 0.0458579955867156 325 2970608
SGTC_3178 9107506 49.47 µM 1.68620739328873 0.0410650642860723 no 194 0.0458779301904933 324 8897194
SGTC_859 0439-0102 54.6 µM 1.67937720467231 0.0416904994745203 no 195 0.046539276509607 351 610143
SGTC_2016 5121758 140 µM 1.67769011743518 0.0418461671777034 no 196 0.0467038048519588 393 2795203
SGTC_3101 9120531 49.47 µM 1.67292112875526 0.0422887491498039 no 197 0.047171411879323 358 24824904
SGTC_1867 st057372 64 µM 1.67198083957194 0.0423764572785863 no 198 0.0472640501971575 326 688837
SGTC_351 caspofungin 25 nM 1.66605794032207 0.0429323204361138 no 199 0.0478509373520574 488 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_83 0170-0301 39.027 µM 1.65944180929997 0.0435601942954673 no 200 0.0485133986597666 185 3089716
SGTC_645 0845-0943 5.41 µM 1.6590842161805 0.0435943400458557 no 201 0.0485494116749384 324 1885106
SGTC_2182 6325192 200 µM 1.65776799093073 0.0437202095131684 no 202 0.0486821521998775 300 736248
SGTC_1311 1190-0148 100 µM 1.65462850067088 0.0440216202112312 no 203 0.0489999392789991 421 1961333
SGTC_1630 st005209 31.3 µM 1.65262067750766 0.0442152607201034 no 204 0.0492040435566348 392 3367314
SGTC_1809 st050081 57.6 µM 1.65138545460757 0.044334730076063 no 205 0.0493299464887815 328 5036894
SGTC_2017 5132927 60.65 µM 1.63421263258585 0.0460227662560978 no 206 0.0511071054693322 373 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_853 0419-0306 21 µM 1.63415377971877 0.0460286388667429 no 207 0.0511132824194572 320 762713
SGTC_24 0417-1663 219 µM 1.63149606296237 0.0462944661128802 no 208 0.0513928449571974 347 4329390
SGTC_2432 5630864 12.22 µM 1.63047505699423 0.0463969152236819 no 209 0.0515005663560659 351 5714970
SGTC_259 usnic acid 108.925 µM 1.6253568666898 0.0469132273135831 no 210 0.0520432704788572 371 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2865 9030313 51.95 µM 1.62240538230866 0.0472130552736795 no 211 0.0523582887404791 322 42562754
SGTC_22 0964-0034 14.468 µM 1.62150994657823 0.0473043216091934 no 212 0.052454159270738 407 138402
SGTC_2336 9001819 198.65 µM 1.62101272884816 0.0473550610189457 no 213 0.0525074544211203 408 2989602
SGTC_1328 1441-0025 69.2 µM 1.61912360761896 0.0475482372824375 no 214 0.0527103351604355 315 4562601
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.61786131844915 0.0476776668998621 no 215 0.0528462440594182 202 6708630 An antioxidant.
SGTC_2470 5664817 21.68 µM 1.61171559122471 0.0483118590208876 no 216 0.0535119216657806 314 2859561
SGTC_3151 9099821 49.47 µM 1.61166554718249 0.0483170507466287 no 217 0.0535173693558787 321 17174189
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.61155046360059 0.0483289915712073 no 218 0.0535298987817764 346 5282362
SGTC_1539 benzyladenosine 56 µM 1.61142838308969 0.0483416609620533 no 219 0.0535431925203369 326 92208 A nucleotide analog.
SGTC_2561 acetosyringone 100 µM 1.60668193159994 0.0488363057544436 no 220 0.0540620795923301 429 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1425 4048-4433 7.33 µM 1.60273025550207 0.0492512024408968 no 221 0.0544971103625649 413 23734946
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.59986019332299 0.0495542984786431 no 222 0.0548148009073833 192 4000243
SGTC_1873 rapamycin 2 nM 1.5975373596837 0.0498006922298515 no 223 0.0550729884017096 431 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2684 capsaicin 100 µM 1.59677843036001 0.0498814068732097 no 224 0.055157552811377 343 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1373 2887-0003 58.5 µM 1.59505632188476 0.0500649458136819 no 225 0.0553498208050162 376 776948
SGTC_1051 3253-3903 78 µM 1.59480144624191 0.0500921556453756 no 226 0.0553783217758059 404 5509239
SGTC_1072 oxiconazole 14.9 nM 1.59255940467466 0.0503320182558749 no 227 0.0556295332933845 413 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1245 0418-0076 17.2 µM 1.59011401370974 0.0505946786882418 no 228 0.055904553859451 390 6790114
SGTC_2765 myclobutanil 7.74 µM 1.58761633188615 0.0508640816369344 no 229 0.05618656142662 385 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1925 st057770 10.1 µM 1.58542574787059 0.0511012996102504 no 230 0.0564348174897626 355 5989122
SGTC_2228 7354201 200 µM 1.5843613663899 0.0512168786969691 no 231 0.0565557541433659 323 753451
SGTC_1226 3909-7979 35.4 µM 1.58104280015662 0.0515785708703266 no 232 0.0569341259495227 442 6615510
SGTC_2112 5488546 200 µM 1.57930578107993 0.0517686975486811 no 233 0.0571329682417888 387 600757
SGTC_3214 9129694 49.47 µM 1.57636365866559 0.0520920000729762 no 234 0.0574710092830417 362 17158655
SGTC_887 0885-0007 9.62 µM 1.57401219065911 0.0523515485503191 no 235 0.0577423155732339 413 5719458
SGTC_1486 3970-0793 4.53 µM 1.57323307646094 0.0524377711100241 no 236 0.0578324295284682 355 2844330
SGTC_2549 cedrol 20.94 µM 1.56769292313713 0.0530541408342925 no 237 0.0584764070238024 320 6708665 A sedative which affects the nervous system.
SGTC_642 0335-0876 158 µM 1.56618796808871 0.0532225631009497 no 238 0.0586523093247502 415 6812350
SGTC_2202 7226349 200 µM 1.56515280092159 0.053338656379662 no 239 0.0587735427549001 309 844334
SGTC_2912 7964298 10.93 µM 1.56450745506508 0.0534111329726228 no 240 0.0588492217927999 462 2975850
SGTC_479 n-linoleoylglycine 10 µM 1.5624746831659 0.0536399368259905 no 241 0.0590881027073103 326 6433346 An anti-infammatory.
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.56214222106302 0.0536774317172454 no 242 0.059127244215756 364 97141
SGTC_1845 st056753 3.01 µM 1.55788130408125 0.0541598157482631 no 243 0.0596306939485733 419 5375839
SGTC_1673 st016611 27.3 µM 1.55764763216306 0.0541863689629101 no 244 0.0596584003773903 421 5226799
SGTC_1182 1222-0449 220 µM 1.55453212388991 0.0545413836961463 no 245 0.0600287701066138 356 658318
SGTC_1977 st070720 65.3 µM 1.55073067761109 0.0549770503118607 no 246 0.0604831197566484 349 682188
SGTC_2568 diosmetin 100 µM 1.54983761220906 0.055079798361187 no 247 0.0605902484512697 415 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1633 st005664 67.9 µM 1.54786413427032 0.0553073869630356 no 248 0.0608275056777411 420 2063822
SGTC_2624 nerol 100 µM 1.54447815955305 0.0556995993250183 no 249 0.061236269124589 358 637566 A natural product oil.
SGTC_2281 7943571 200 µM 1.54090272184816 0.0561161372812007 no 250 0.0616702316513303 403 1244024
SGTC_151 3013-0144 2.285 µM 1.54002718383555 0.0562185108141265 no 251 0.061776863682236 423 906558 YHR107C CDC12
SGTC_1906 st060206 94.7 µM 1.53904057846964 0.0563340474487308 no 252 0.0618971950535099 424 5133468
SGTC_1146 3579-1023 7 µM 1.53651099758633 0.0566311297751764 no 253 0.0622065513119681 454 X1146
SGTC_1896 st058441 89 µM 1.53639414327489 0.0566448833010298 no 254 0.0622208711546343 362 688759
SGTC_1720 st037298 9.481 µM 1.53565112375955 0.0567323968300341 no 255 0.0623119842045897 389 597396
SGTC_2583 asiatic acid 100 µM 1.53288198377245 0.0570594871159232 no 256 0.0626524678343592 372 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1674 st016616 23.6 µM 1.53110231573291 0.057270483619004 no 257 0.0628720538007693 412 625830
SGTC_597 k018-0003 82.8 µM 1.5286936964929 0.0575570255083849 no 258 0.0631701978538005 409 6786234
SGTC_260 nsc-65238 3.989 µM 1.52529777936125 0.0579629357591931 no 259 0.0635924207059279 375 3246252
SGTC_942 3253-1115 227 µM 1.5243886264696 0.0580719867304863 no 260 0.0637058297785254 404 46497897
SGTC_2663 amphotericin b 100 µM 1.52408610874254 0.0581083088210013 no 261 0.0637436011547492 387 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2239 6685329 187.64 µM 1.51915235283516 0.0587032081508205 no 262 0.064362075729721 427 805680
SGTC_120 rhodamine 6G 52.259 µM 1.51794166369108 0.0588499178779925 no 263 0.0645145527740048 502 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1560 lithocholic acid 53.1 µM 1.51680510005394 0.0589879068624914 no 264 0.064657949512324 303 9903 A bile acid which acts as a detergent.
SGTC_1603 st002045 67.8 µM 1.51492805598311 0.0592163524103408 no 265 0.0648953122315064 408 5887985
SGTC_663 1486-0733 13.9 µM 1.51287127420323 0.059467468938662 no 266 0.0651561799345598 477 722445 YPR165W RHO1
SGTC_2898 9056270 58.44 µM 1.51223414261961 0.0595454266911863 no 267 0.0652371540744141 333 19154699
SGTC_1367 1812-0510 76.9 µM 1.51179977930573 0.0595986201497133 no 268 0.0652924027928529 410 1142582 YDR527W RBA50
SGTC_2775 cyproheptadine 69.59 µM 1.51143254248672 0.0596436221379485 no 269 0.0653391416879009 411 2913 A selective serotonin reuptake inhibitor.
SGTC_845 0330-0138 4.51 µM 1.50987740998175 0.0598344866027665 no 270 0.0655373539328094 404 9039800
SGTC_677 0929-0063 136 µM 1.50838997617347 0.0600174896160968 no 271 0.0657273734845126 338 1539583
SGTC_1172 0370-0043 85 µM 1.50756695988982 0.0601189357298942 no 272 0.0658326971312079 382 376585
SGTC_1656 st012921 11 µM 1.49916802608301 0.0611618910042297 no 273 0.0669150237829543 388 6732821
SGTC_958 1222-0007 33 µM 1.49663542479007 0.0614791413052536 no 274 0.0672440736274054 443 7312461
SGTC_1133 3473-0247 50 µM 1.49637017627293 0.0615124422994121 no 275 0.0672786084560762 456 711311
SGTC_1104 tacrolimus 29.8 µM 1.4951184699968 0.0616697796391753 no 276 0.0674417631719681 445 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_753 1322-0200 289 µM 1.49373039831533 0.0618446251184589 no 277 0.0676230499442206 417 5403907
SGTC_2301 7769476 200 µM 1.48914684272694 0.0624247322357065 no 278 0.0682243525216506 379 977820
SGTC_2840 9008771 71.43 µM 1.48683788506598 0.0627185627274095 no 279 0.068528816435819 357 2992978
SGTC_458 nppb 133 µM 1.48549192481586 0.0628903419069411 no 280 0.0687067804698026 373 4549 A chloride channel blocker.
SGTC_132 0417-1715 25.805 µM 1.48545554929633 0.0628949894416496 no 281 0.0687115950139286 447 6769098
SGTC_2040 5100729 123 µM 1.48179759060386 0.0633637180524532 no 282 0.0691970801994683 443 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1783 st039459 87.517 µM 1.48178873490377 0.0633648561070183 no 283 0.0691982587287715 479 729761
SGTC_3077 9117319 49.47 µM 1.47747589165714 0.0639209970243659 no 284 0.0697740580209437 364 17154678
SGTC_3044 9093193 49.47 µM 1.47555226564624 0.0641702693595844 no 285 0.0700320637957952 461 25236277
SGTC_1734 st037168 69.4 µM 1.47477860791719 0.0642707363070656 no 286 0.0701360371366598 433 708907
SGTC_2767 sibutramine 71.45 µM 1.47445224714532 0.0643131540574397 no 287 0.070179932977508 432 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_783 0848-0141 92.7 µM 1.47439070197203 0.0643211556421354 no 288 0.0701882132307684 408 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1652 st011932 78 µM 1.47381764144116 0.0643956972857992 no 289 0.0702653485504555 412 1551076
SGTC_2708 st078559 56 µM 1.47291253802255 0.0645135665779293 no 290 0.0703873104106898 322 17250902
SGTC_883 0850-0245 24.6 µM 1.46615821890149 0.0653984634118454 no 291 0.0713025940500916 468 6823229 YPR165W RHO1
SGTC_1908 st060353 56.5 µM 1.45495085047604 0.0668874973293756 no 292 0.0728414343491876 502 4227716
SGTC_1692 fluoroquinolonic acid 71 µM 1.45442298234163 0.0669582724545536 no 293 0.0729145360018273 404 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1453 4237-0541 195 µM 1.45403449772205 0.0670103964098981 no 294 0.0729683710355363 425 739892
SGTC_26 0302-0163 425.158 µM 1.45305614980586 0.0671418028389957 no 295 0.0731040823383949 423 3100915
SGTC_2089 5281248 129.67 µM 1.44658840339397 0.0680155342321745 no 296 0.0740061180257983 457 2737878
SGTC_271 rotenone 740 µM 1.44431750504786 0.0683243847628047 no 297 0.0743248419729828 492 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_918 glabranin 770.725 nM 1.44329984144662 0.0684631414262508 no 298 0.074468012220323 479 124049 Also referred to as licorice root.
SGTC_3003 9075612 71.4286 µM 1.44133525945711 0.068731623578441 no 299 0.0747449953099488 453 6501993
SGTC_961 1252-1571 372 µM 1.4337681107846 0.0697733505359905 no 300 0.0758192240175758 473 6813498
SGTC_760 0568-0725 82.9 µM 1.42347146682862 0.071210297255849 no 301 0.0772997639306024 467 3916171
SGTC_284 0988-0104 32.6 µM 1.42319429242367 0.0712492899929932 no 302 0.0773399198618133 492 4666532
SGTC_493 zm226600 134 µM 1.42287404606929 0.0712943624755454 no 303 0.0773863356147603 476 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2810 7959871 45.46 µM 1.41152173871564 0.0729063023345096 no 304 0.0790454151689133 549 2974535
SGTC_2227 7312221 64.1025 µM 1.41010152458214 0.0731099097404425 no 305 0.0792548535887649 412 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_306 1672-3436 11.6 µM 1.40950520286079 0.0731955303276483 no 306 0.0793429180483484 479 6797378
SGTC_1883 5-benzylidenerhodanine 20 µM 1.40346526991768 0.0740670799470589 no 307 0.0802390707122948 552 1273210
SGTC_3301 9125354 19.7965 µM 1.40250968108548 0.074205692786737 no 308 0.0803815508070655 426 41905162
SGTC_571 k831-0106 44.2 µM 1.40099308999745 0.0744260883692185 no 309 0.0806080697275996 450 4783639
SGTC_2267 7931562 200 µM 1.40012295147871 0.0745527649453781 no 310 0.0807382516048305 438 934880
SGTC_928 2764-0428 58.7 µM 1.39736178801406 0.0749558306679052 no 311 0.0811524019569342 517 662578
SGTC_990 3985-0011 41.3 µM 1.39628961708201 0.0751127899758768 no 312 0.0813136495890732 431 5399565 YGL099W LSG1
SGTC_2098 5376439 882.5 nM 1.39029648982618 0.0759947668880046 no 313 0.0822194316655004 512 2844116
SGTC_1506 4226-2149 212 µM 1.38704650315904 0.0764763361530323 no 314 0.0827137915611801 544 991114
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.38465633289625 0.0768319803948884 no 315 0.0830787886915504 531 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3255 9139072 49.47 µM 1.3828268990967 0.077105038580781 no 316 0.0833589744939924 486 17646060
SGTC_2011 4012611 177 µM 1.3791316213407 0.0776588377809834 no 317 0.0839270879388577 505 2049887
SGTC_1302 1159-0335 255 µM 1.37912462202782 0.0776598896028546 no 318 0.0839281667679322 473 649284
SGTC_3063 1327-0034 4 µM 1.37841523193639 0.0777665493172738 no 319 0.0840375616169141 474 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1726 st035556 14.5795 µM 1.37751139306931 0.0779026062429564 no 320 0.0841770974103626 533 5919439
SGTC_1282 0886-0010 32.4 µM 1.37444092177319 0.078366160599315 no 321 0.0846524196485748 561 2836211 YNL267W PIK1
SGTC_2738 aclarubicin 5.55 µM 1.37139559756301 0.0788279813617344 no 322 0.0851258345539193 384 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_550 4123-0385 25.7 µM 1.37045796786277 0.0789705864479903 no 323 0.0852719937588638 489 5731123
SGTC_1665 st014639 11.4 µM 1.36988779495573 0.0790574001376537 no 324 0.0853609650972015 554 981133 YIL048W NEO1
SGTC_931 2812-0076 566 µM 1.36790256569039 0.0793602322042191 no 325 0.0856712882827059 520 3450959
SGTC_1434 4073-0095 163 µM 1.35742702335525 0.0809727558245747 no 326 0.0873227833056911 526 24133745
SGTC_922 1866-0035 480 µM 1.35546299133302 0.0812778176511044 no 327 0.087635046019895 608 3156169
SGTC_1788 fluconazole 20 µM 1.35537510206682 0.0812914892272938 no 328 0.0876490390415814 494 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_273 hydroxyurea 18.1 mM 1.35214015409611 0.0817959080711614 no 329 0.08816524203986 582 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2218 6965428 192.983 µM 1.34787044751965 0.0824652818630731 no 330 0.0888500273147979 517 675684
SGTC_574 1315-0397 40 µM 1.34783526227314 0.0824708150333318 no 331 0.0888556868098183 594 6794277
SGTC_708 3448-5400 146 µM 1.34644588846352 0.0826895290193554 no 332 0.0890793801496698 544 3462195
SGTC_2439 5492030 7.2 µM 1.33912210366234 0.0838496528526946 no 333 0.0902654629052868 499 5722370
SGTC_473 2-arachidonoylglycerol 10 µM 1.33551512009948 0.0844254904336413 no 334 0.0908539049741599 524 5282280 An endocannabinoid.
SGTC_85 0868-0259 160.055 µM 1.33409326986979 0.0846532955323931 no 335 0.0910866456127053 498 83173
SGTC_2061 5245884 80.95 µM 1.33243751737325 0.0849191564915041 no 336 0.0913582303275389 543 573863
SGTC_891 0929-0073 133 µM 1.32930598376983 0.0854236913838757 no 337 0.0918735204601704 519 5603632
SGTC_666 0272-0154 136 µM 1.32618607714817 0.085928582414403 no 338 0.0923890349270843 559 6870312
SGTC_1659 st012954 42.1 µM 1.32335343899219 0.0863889163117991 no 339 0.0928589340456251 503 24207262
SGTC_3030 9087619 49.47 µM 1.32236892600473 0.0865493412420117 no 340 0.0930226655197377 509 25236973
SGTC_3264 9137442 49.47 µM 1.32069093893828 0.0868232798269533 no 341 0.0933022182830927 496 17015726
SGTC_1919 st067113 52.3 µM 1.31518659406007 0.0877264359867828 no 342 0.0942235997499886 557 1268243
SGTC_1791 st048313 56.1 µM 1.31356284539981 0.0879941957139492 no 343 0.0944966794892348 481 1204976
SGTC_3268 9137683 49.47 µM 1.31161236779001 0.0883166388702141 no 344 0.0948254789484843 470 1953228
SGTC_84 0443-0269 128.823 µM 1.3100068242309 0.0885827193351632 no 345 0.0950967635038465 543 6150058
SGTC_2623 humulene 100 µM 1.30557992181262 0.0893194652038418 no 346 0.0958477259787249 465 6187145 An anti-inflammatory.
SGTC_1770 st043884 66.3 µM 1.30264307854738 0.0898107375707724 no 347 0.096348321724314 550 670149
SGTC_2902 5787006 60.46 µM 1.30139897673276 0.0900194543186692 no 348 0.0965609618631594 518 591003
SGTC_1294 1000-1494 117 µM 1.30054442361275 0.090163027091396 no 349 0.0967072204899815 534 712797 YDL207W GLE1
SGTC_73 0327-0325 16.231 µM 1.30033885694475 0.0901975895472388 no 350 0.0967424279375176 631 53298
SGTC_2036 5160441 105 µM 1.29722252963084 0.0907227517885217 no 351 0.0972773154910745 628 134534 YIL048W NEO1
SGTC_1316 1272-0050 65.9 µM 1.2948064103599 0.0911314743850259 no 352 0.0976935100346774 551 7340392
SGTC_2813 7971799 71.43 µM 1.29271298176351 0.0914867118739995 no 353 0.098055173089954 506 2234054
SGTC_3257 9139206 32.98 µM 1.2821419211978 0.093296219972731 no 354 0.0998964327565715 482 4910041
SGTC_1220 1838-0075 193 µM 1.28079353833575 0.0935289186819429 no 355 0.100133097136172 569 5529645
SGTC_316 k060-0003 58.6 µM 1.2804718944144 0.0935844900130663 no 356 0.100189611593752 544 6152314
SGTC_758 0868-0029 16 µM 1.27949911971208 0.0937527074320813 no 357 0.100360674703055 556 762687
SGTC_2851 9015922 71.43 µM 1.27569917164488 0.0944119540520179 no 358 0.101030940762876 569 2996893
SGTC_2713 st079149 53.4 µM 1.27459741397158 0.094603733869065 no 359 0.101225886643051 598 3103253
SGTC_1433 4060-0023 7.6 µM 1.27306474809276 0.0948709980308357 no 360 0.101497533422892 581 3840627
SGTC_3140 9094243 49.47 µM 1.26942788457425 0.0955074147673483 no 361 0.102144248050061 571 19291112
SGTC_1618 st003135 44.5 µM 1.26793623003715 0.0957693468874637 no 362 0.102410362280009 553 1270615
SGTC_2952 9073731 13.78 µM 1.26581941706723 0.0961419623525238 no 363 0.102788870878659 606 16457353
SGTC_944 3370-0224 231 µM 1.26555996995012 0.0961877051765453 no 364 0.102835332617931 568 4580514
SGTC_2515 chrysin 20.77 µM 1.26553329590825 0.0961924089531396 no 365 0.102840110265117 586 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1777 st045864 34.765 µM 1.26002558311279 0.0971672804132497 no 366 0.103830066739861 574 4691462
SGTC_111 0083-0039 52.457 µM 1.2568667989735 0.0977296502080861 no 367 0.104400936314617 416 759313
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.25618775454748 0.0978508539491838 no 368 0.104523952708896 547 641818 YHR062C RPP1
SGTC_798 1287-0182 476 µM 1.25320442959318 0.098384657942719 no 369 0.105065659160227 643 1649755
SGTC_1159 4092-0538 61.2 µM 1.25240238905397 0.0985285294710619 no 370 0.105211638111958 628 717301
SGTC_1113 artemisinin 1.17947 µM 1.25170615005504 0.0986535469613501 no 371 0.105338479135852 597 2240 An anti-malaria and mitochondrial poison.
SGTC_771 0250-0039 27.3 µM 1.2511264964899 0.0987577187754534 no 372 0.105444164951691 579 3005115
SGTC_1713 st033146 12.748 µM 1.2502338749036 0.0989182926918305 no 373 0.105607062873425 587 674619
SGTC_3339 9145883 14.936 µM 1.24895588395844 0.0991485231871938 no 374 0.105840604976405 536 2030670
SGTC_404 fumagillin 50 µM 1.2475631400508 0.099399872443933 no 375 0.106095542044216 604 12015870 A methionine aminopeptidase binder.
SGTC_232 clozapine 119 µM 1.24503972867768 0.099856459790865 no 376 0.106558573488262 575 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_372 0155-0182 15.9 µM 1.2445052728245 0.0999533607847932 no 377 0.106656829979432 648 771486
SGTC_1348 1493-0373 93.8 µM 1.24434105361619 0.0999831487891317 no 378 0.106687033821413 580 3010129
SGTC_712 r015-0009 80.6 µM 1.23926788107394 0.100906576297125 no 379 0.107623154622755 521 6813872 YLR060W FRS1
SGTC_664 1222-0054 14.9 µM 1.23862078436149 0.101024807639024 no 380 0.107742983620531 613 6813991
SGTC_198 3454-2873 16.191 µM 1.23808600323516 0.101122593931951 no 381 0.107842086595696 584 710957
SGTC_1778 st046819 58.9 µM 1.23739781080133 0.101248533411051 no 382 0.107969715575842 643 671715
SGTC_2404 5161160 200 µM 1.23600768106578 0.101503276193632 no 383 0.108227854272706 610 2831543
SGTC_491 tetrandrine 80.3 µM 1.23087229044463 0.102448389340095 no 384 0.109185316365284 544 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.2240910220903 0.10370618973937 no 385 0.110458946232452 630 5379071
SGTC_2646 retinol 96.75 µM 1.22128732795445 0.104229483945264 no 386 0.110988624818089 584 445354 A vitamin A analog and teratogen.
SGTC_739 1486-1183 203 µM 1.21836508330277 0.104776939234463 no 387 0.111542633839491 628 4346692
SGTC_3013 9080133 71.4286 µM 1.21798289159876 0.104848692977269 no 388 0.111615237102336 658 17050193
SGTC_2294 7971431 200 µM 1.21672399647613 0.105085293074871 no 389 0.11185462291354 541 5741572
SGTC_919 tnp00227 403.569 nM 1.21637688679119 0.105150597701781 no 390 0.111920692254137 651 1269246 A methoxyflavone. YNL221C POP1
SGTC_3202 9113761 49.47 µM 1.21226000295469 0.105927382010981 no 391 0.112706434623974 672 4798415
SGTC_703 3875-0075 71.8 µM 1.21158064403012 0.106055962819269 no 392 0.112836473784002 650 2850814
SGTC_1944 st076371 56.9 µM 1.20532669252172 0.107244934941268 no 393 0.114038604511061 592 24208455
SGTC_3122 9126309 49.47 µM 1.19971301914823 0.108320339156202 no 394 0.115125407497173 601 17591206
SGTC_2537 larixol 68.93 µM 1.19878281896293 0.108499283301968 no 395 0.115306202446586 676 6708759
SGTC_539 4859-0462 2.54 µM 1.19739386696641 0.108766873992827 no 396 0.11557653650441 620 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2272 7805186 180 µM 1.19535507487945 0.109160519659642 no 397 0.115974165103459 605 2956062 YPR165W RHO1
SGTC_428 3448-4153 16.5 µM 1.1939072777852 0.109440678192015 no 398 0.116257120171599 544 3834874
SGTC_1179 1021-1431 9.29 µM 1.1936841968433 0.109483891738161 no 399 0.116300762259791 667 2840958
SGTC_1600 coumarin 106 71.1 µM 1.18758363940332 0.110670398580993 no 400 0.117498743333697 659 100336 A hepatotoxic, DNA x-linker.
SGTC_2441 5730946 39.09 µM 1.18758313299039 0.110670497455046 no 401 0.117498843140537 638 1774275
SGTC_2601 securinine 100 µM 1.18525719713539 0.11112529041639 no 402 0.117957885691759 614 442872 A GABA receptor antagonist.
SGTC_1571 st070080 73.4 µM 1.17113970333302 0.113914426654214 no 403 0.120771313553578 634 4315245
SGTC_3243 9134147 49.47 µM 1.16853400091956 0.114434630808519 no 404 0.121295716305212 675 24282180
SGTC_375 3970-0961 9.27 µM 1.16769574605759 0.114602339542829 no 405 0.121464756662023 649 2898222
SGTC_1388 3346-4487 254 µM 1.16482264023454 0.115178485685657 no 406 0.122045396247649 684 3345614
SGTC_636 0kpi-0074 126 µM 1.15629101175335 0.1169014672927 no 407 0.123781071793428 628 616434
SGTC_1078 idebenone 36.1 µM 1.15592545605337 0.11697569806048 no 408 0.123855824618556 706 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1055 3448-0672 86 µM 1.15239018622399 0.1176953038302 no 409 0.12458038594728 649 748378
SGTC_222 nsc-310342 10.666 µM 1.15064561421753 0.118051564498317 no 410 0.124939029607962 543 432556
SGTC_3276 9139060 49.47 µM 1.14868892267183 0.118452049029017 no 411 0.125342137578542 614 4870619
SGTC_2776 terbinafine 19.92 µM 1.14628078955459 0.11894624899733 no 412 0.125839494480996 633 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2353 9059630 146.67 µM 1.1459108542326 0.11902229640022 no 413 0.125916019814049 638 4779114
SGTC_1662 st014054 52 µM 1.14342097754727 0.119535032163778 no 414 0.126431923442622 636 2838777
SGTC_1477 0139-0234 16 µM 1.14242618803362 0.119740322364759 no 415 0.126638455469061 670 620880
SGTC_2073 5212005 126 µM 1.14208526227147 0.11981073483852 no 416 0.126709290392269 567 691789
SGTC_2164 5685496 200 µM 1.14156289404471 0.119918677824001 no 417 0.126817877546132 702 759046
SGTC_2033 5192550 145 µM 1.14092251664743 0.120051099923422 no 418 0.12695108419876 643 182073
SGTC_459 nigericin 15.3 µM 1.14050511679898 0.120137468493011 no 419 0.12703796109186 694 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3146 9095609 49.47 µM 1.13963166929331 0.120318344312725 no 420 0.127219892827377 680 17173999
SGTC_1141 3253-0389 52.6 µM 1.13751066179052 0.120758366433472 no 421 0.127662435044039 667 5402031
SGTC_1987 st072290 61.9 µM 1.13695108356086 0.120874644585451 no 422 0.127779367653387 692 54697379
SGTC_2434 5670830 169.91 µM 1.13525305811569 0.121227969824541 no 423 0.128134652160211 667 1549830
SGTC_2480 5767542 37.17 µM 1.12775864224868 0.12279608385047 no 424 0.129710932049575 699 2867358
SGTC_1429 4049-0205 9.46 µM 1.12775150455619 0.122797584073829 no 425 0.129712439674109 740 22774478
SGTC_2383 9036125 200 µM 1.12770441449745 0.122807481937266 no 426 0.129722386347904 633 79580
SGTC_2923 7992654 58.14 µM 1.12191382072869 0.124028874264877 no 427 0.130949541859278 659 2985126
SGTC_2268 7933382 153.85 µM 1.12066019146898 0.12429441396275 no 428 0.131216266612519 758 935025 YOR257W CDC31
SGTC_3220 9131269 49.47 µM 1.11881478194829 0.12468602569512 no 429 0.131609582068758 679 17722206
SGTC_1931 st074438 57.1 µM 1.11689812881587 0.125093668014362 no 430 0.132018942394951 652 2787313
SGTC_755 1995-0008 37.3 µM 1.11642447266793 0.12519455058385 no 431 0.132120241428526 719 689533
SGTC_2536 dehydroabietamide 32.04 µM 1.11639508264284 0.125200812146448 no 432 0.132126528726511 734 3983547
SGTC_172 1112-0046 2.638 µM 1.11635204387162 0.125209981977235 no 433 0.132135736221878 610 2802135 YIL048W NEO1
SGTC_1426 4048-4480 71.7 µM 1.11359704811553 0.125797936766423 no 434 0.132726046684147 703 14224343
SGTC_1832 st054113 55 µM 1.11344252638844 0.125830970813374 no 435 0.132759209625349 661 1251267
SGTC_710 3448-4187 58 µM 1.11285533146525 0.125956558012938 no 436 0.132885283498841 788 3946412
SGTC_1698 5-fluorocytosine 1.055 µM 1.11269556796259 0.12599074279333 no 437 0.132919599833835 699 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_171 k064-0041 9.68 µM 1.11264897804349 0.126000712910115 no 438 0.132929608245068 576 53325
SGTC_1813 st051246 8.6015 µM 1.11143598260612 0.126260484282516 no 439 0.133190365623326 655 5291959
SGTC_2695 st077686 51.995 µM 1.11092165209231 0.126370744331045 no 440 0.133301037346341 657 2876092
SGTC_1231 0242-0792 125 µM 1.10885944867308 0.126813504678398 no 441 0.13374540990297 686 3707635
SGTC_1512 0259-0544 12.2 µM 1.10744741736336 0.127117293663368 no 442 0.134050267283372 756 18476
SGTC_1575 cyproterone acetate 48 µM 1.10722924768683 0.127164276521402 no 443 0.13409741263742 668 9880 An androgen receptor antagonist and liver toxin.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.10459386051576 0.127732761938476 no 444 0.134667806285292 701 7104
SGTC_1546 5-methoxyflavanone 78.7 µM 1.10398679794846 0.12786396272848 no 445 0.134799432311458 743 147795
SGTC_2827 7993847 71.43 µM 1.10366634306176 0.127933258472111 no 446 0.134868950361119 643 2985692
SGTC_591 4299-0174 154 µM 1.10325031857953 0.128023259278399 no 447 0.134959237537086 694 5509088
SGTC_1983 st071813 46.9 µM 1.10318144219586 0.128038163918506 no 448 0.134974189344419 706 11838595
SGTC_2845 9003024 42.97 µM 1.10272242903164 0.12813752375704 no 449 0.135073861750826 710 2990173
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.10151952788212 0.128398162607889 no 450 0.13533530511953 672 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_51 1013-0126 23.419 µM 1.10055187111215 0.128608096782535 no 451 0.135545871114066 672 1627850
SGTC_3160 9100216 49.47 µM 1.09605648965251 0.1295864976943 no 452 0.136527027057387 711 17191039
SGTC_3314 9135860 59.4275 µM 1.09528836939236 0.129754190263696 no 453 0.136695160631071 733 25252478
SGTC_1088 bifonazole 369 nM 1.09222033042896 0.130425489317263 no 454 0.137368134241579 718 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1082 camptothecin 424.86 nM 1.08838130164094 0.131268862310213 no 455 0.13821340613401 623 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_786 4544-0069 423 µM 1.08666595712809 0.131646910667947 no 456 0.138592232093003 744 748821 YLR208W SEC13
SGTC_1957 st077035 62.4 µM 1.08584598845398 0.131827890449632 no 457 0.138773568079565 729 705593
SGTC_2944 9067346 25.62 µM 1.08543583495471 0.131918482049008 no 458 0.138864334087317 704 6473075
SGTC_2773 thioridazine 9.09 µM 1.0847721578568 0.132065160961657 no 459 0.139011289887334 736 5452 An antipsychotic.
SGTC_157 1348-1695 65.819 µM 1.08146703342834 0.132797299092334 no 460 0.139744708707254 758 5380510
SGTC_1650 st011916 45.8 µM 1.08089871758223 0.132923471266346 no 461 0.1398710845815 730 242528
SGTC_2159 5658611 73.75 µM 1.08071457766552 0.132964369987817 no 462 0.13991204826262 728 793844
SGTC_813 k007-0158 173 µM 1.0801228682489 0.1330958512961 no 463 0.140043734858362 808 6523916
SGTC_413 propylparaben 100 µM 1.08006009834773 0.133109804385009 no 464 0.140057709415634 701 7175 A pharmaceutical preservative.
SGTC_916 4466-0038 42 nM 1.0793492529337 0.13326788810382 no 465 0.140216032116813 857 5722064 YGL116W CDC20
SGTC_1856 st057054 55.7 µM 1.07705023859213 0.133780046317554 no 466 0.140728911101284 764 1266018
SGTC_849 0386-0493 241 µM 1.07492888564462 0.134253825129487 no 467 0.141203284168795 704 726119
SGTC_2305 7443522 69.23 µM 1.07478690425297 0.134285576069391 no 468 0.141235072450564 774 5415886
SGTC_583 1488-1091 88.9 µM 1.07189872376512 0.134932572127623 no 469 0.141882761756556 855 4303273
SGTC_1392 3455-1037 33.9 µM 1.06752801432913 0.135915737715526 no 470 0.142866735145497 729 981132
SGTC_469 w7 172 µM 1.06522782546918 0.136435116938588 no 471 0.14338642233638 703 45115570 A P450 inhibitor.
SGTC_2757 clomiphene 4.22 µM 1.06468041841815 0.136558920365924 no 472 0.143510287118647 825 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1569 carminic acid 40.6 µM 1.05761106462425 0.138164652854444 no 473 0.145116398010214 759 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2998 9066762 71.4286 µM 1.05479191103657 0.138808571594724 no 474 0.145760252457019 773 4945196
SGTC_180 1486-1293 102.781 µM 1.05474099804868 0.138820219313053 no 475 0.145771897881866 761 4140536
SGTC_1214 0358-0031 63.7 µM 1.05113953603581 0.139645839960486 no 476 0.146597254105396 727 4301366
SGTC_2385 9074692 200 µM 1.05072707894728 0.139740606730413 no 477 0.146691977710562 747 17046906
SGTC_2595 hexamethylquercetagetin 100 µM 1.04882786984346 0.140177535998391 no 478 0.147128673983828 702 386331
SGTC_1646 st011709 75.6 µM 1.04879199220336 0.140185798877058 no 479 0.14713693191914 706 5757843
SGTC_3170 9103054 49.47 µM 1.04698567527909 0.140602234340621 no 480 0.147553092492261 700 16432970
SGTC_3141 9094609 49.47 µM 1.04674899699198 0.140656861243935 no 481 0.147607679594816 698 25236309 YDL196W YDL196W
SGTC_1459 k035-0031 35.7 µM 1.04472113803143 0.141125494808442 no 482 0.148075936170029 667 3877128 YMR208W ERG12
SGTC_876 0720-0963 56.8 µM 1.0436133863701 0.141381940329569 no 483 0.148332148507904 803 765861
SGTC_2687 chenodiol 100 µM 1.04084023946646 0.142025310678295 no 484 0.148974850498934 711 5702181 A cholesterol synthesis inhibitor.
SGTC_2541 muurolladie-3-one 83.07 µM 1.03986214253356 0.142252701309875 no 485 0.149201976503185 726 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_3103 9120822 49.47 µM 1.03857266491813 0.142552858846417 no 486 0.14950176209713 784 17141819
SGTC_3267 9137951 49.47 µM 1.03820707265326 0.142638037286769 no 487 0.149586830305783 736 16643986
SGTC_1920 st075728 45.7 µM 1.03585425261948 0.143187038348221 no 488 0.150135071370116 756 3400306
SGTC_367 0335-0881 7.1 µM 1.03522361811707 0.143334431234583 no 489 0.150282245653228 777 23828853
SGTC_555 4296-0685 37 µM 1.03511571211017 0.143359661457493 no 490 0.150307437839824 799 2908540 YHR072W ERG7
SGTC_1338 1486-1223 76 µM 1.03254622236528 0.143961336943603 no 491 0.150908152992546 807 3444526
SGTC_1342 1486-1464 234 µM 1.02910626668027 0.144769504898157 no 492 0.151714870853518 793 3253938
SGTC_2507 purpurin 79.67 µM 1.02882069250026 0.144836733514798 no 493 0.151781970606731 775 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1889 st059080 5.18 µM 1.02770450636341 0.145099702780799 no 494 0.152044423707255 826 176925 Isolated from Daphnopsis sellowiana.
SGTC_2691 st077356 60.2 µM 1.02551853569892 0.145615639656426 no 495 0.152559291996494 805 2839272
SGTC_1498 4478-3555 97.6 µM 1.02446264633109 0.145865293908005 no 496 0.152808402679254 743 3437919
SGTC_3296 9122258 64.045 µM 1.02334075369841 0.146130868971263 no 497 0.153073380602071 770 4730474
SGTC_1376 2910-0861 41.3 µM 1.0218825865713 0.146476532254665 no 498 0.153418237551098 813 1112859
SGTC_1868 st057644 42.7 µM 1.0217153068588 0.146516221522716 no 499 0.153457832131864 833 688665
SGTC_714 4296-0578 26.1 µM 1.02151578887023 0.14656356917575 no 500 0.153505066260876 757 1589775
SGTC_32 0928-0142 34.1 µM 1.02145176393786 0.146578765121214 no 501 0.15352022564099 773 2244242
SGTC_812 4251-0442 148 µM 1.01865089880422 0.147244569183247 no 502 0.154184365491449 761 5723007
SGTC_2701 st077767 14.721 µM 1.01644215441997 0.147771045485116 no 503 0.15470944016521 816 5721188
SGTC_3274 9138298 49.47 µM 1.01483086967335 0.148155905541328 no 504 0.155093227977203 828 17015756
SGTC_57 miconazole 162.5 nM 1.01402811491023 0.148347895945602 no 505 0.155284668492754 746 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.01333213305687 0.148514484692529 no 506 0.155450772037547 839 676296 Flavone; oxidizing agent.
SGTC_3034 9090421 49.47 µM 1.01277040684889 0.148649029480226 no 507 0.155584919489964 754 17173761
SGTC_58 0957-0393 9 µM 1.00810401214334 0.149769874843036 no 508 0.156702265870008 941 6997992
SGTC_2560 caryophyllene 100 µM 1.00696973396582 0.150043172489558 no 509 0.156974659435643 870 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1942 st076330 65.2 µM 1.00580546227664 0.150324042491278 no 510 0.157254579612452 768 24208414
SGTC_1366 1683-0113 21.9 µM 1.00568564681468 0.150352966756211 no 511 0.157283404874257 767 708623
SGTC_2769 toremifene 3.73 µM 1.00549737440573 0.150398424483699 no 512 0.157328706558954 754 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.00548991879674 0.15040022480339 no 513 0.157330500687409 770 279621
SGTC_672 1441-0018 53.7 µM 1.00515712163538 0.15048060057424 no 514 0.15741059917369 748 251141
SGTC_1164 k060-0068 93.7 µM 1.00225347728663 0.151183090360799 no 515 0.158110592782218 836 5963676
SGTC_890 0929-0006 47.2 µM 0.999173185052657 0.151930698358665 no 516 0.158855401651671 779 1378169
SGTC_3329 9141233 27.5565 µM 0.998246508254731 0.152156088898261 no 517 0.15907991959703 786 4909101 YNL103W MET4
SGTC_175 3793-3120 23.7 µM 0.995828299955962 0.152745301682497 no 518 0.159666788725568 756 5322297
SGTC_892 0929-0076 29 µM 0.995679630907556 0.152781575214019 no 519 0.159702915026973 822 5751038
SGTC_605 1315-0399 119 µM 0.994677402277553 0.15302625649359 no 520 0.159946594263421 852 24020461
SGTC_3313 9133968 57.047 µM 0.992429834579424 0.153575915329018 no 521 0.160493945633775 850 1494643
SGTC_179 1273-0063 6.77 µM 0.989310205627828 0.154341007147123 no 522 0.161255696160258 763 3108139
SGTC_311 1315-0136 58 µM 0.98913246901352 0.154384672967265 no 523 0.161299166758158 819 6759207
SGTC_2937 9044753 11.33 µM 0.988643416664856 0.154504864094825 no 524 0.161418818015292 850 6465530 YGL099W LSG1
SGTC_3305 9127027 53.8275 µM 0.988319058320168 0.1545846135834 no 525 0.161498207251505 813 41905295
SGTC_305 1682-2595 20.8 µM 0.986427483938948 0.155050233933674 no 526 0.161961691889984 838 226033
SGTC_2481 5478948 45.16 µM 0.983261620855104 0.155831596644002 no 527 0.162739346944936 785 77792
SGTC_2273 7815444 169.05 µM 0.98178261420277 0.156197516606556 no 528 0.163103477535463 802 2824616
SGTC_112 phenothiazine 287.218 µM 0.980302799522008 0.156564202596896 no 529 0.163468336620352 871 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2384 9036245 200 µM 0.979930862839523 0.156656454519814 no 530 0.163560123613119 846 6462766
SGTC_3001 9076041 71.4286 µM 0.977921509853079 0.157155455546308 no 531 0.16405657286799 807 16004211
SGTC_1359 1582-0056 520 nM 0.977077216551216 0.15736543816132 no 532 0.164265463100611 883 3661189
SGTC_2723 salbutamol 83.58 µM 0.976735689416275 0.157450431105681 no 533 0.164350010768436 754 9884233 β2-adrenoceptor agonist
SGTC_482 fipronil 114 µM 0.974465491944695 0.158016162447869 no 534 0.164912732529768 814 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1767 st044992 70.3 µM 0.969319376574943 0.159303505178373 no 535 0.166192932236525 803 9600693
SGTC_408 cantharidin 100 µM 0.964540039086762 0.160505229326883 no 536 0.16738762232438 855 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1793 st048256 72.231 µM 0.963339542692608 0.160808012259661 no 537 0.167688577674222 816 672022
SGTC_3137 9097352 49.47 µM 0.962992726021546 0.160895553935312 no 538 0.16777558682375 853 44120435
SGTC_2650 prasterone 100 µM 0.961970743401427 0.161153698388534 no 539 0.168032150191955 779 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2585 alliin 100 µM 0.96061700557123 0.161496057315623 no 540 0.168372387491163 842 87310 A garlic compound which reacts with lipids.
SGTC_954 1189-0853 2.85 µM 0.955817389100013 0.162713693751067 no 541 0.169582250699815 883 2828194
SGTC_2265 7929201 200 µM 0.955524257233261 0.162788252693287 no 542 0.169656322187029 878 1265108
SGTC_1959 st077091 55.8 µM 0.955192200024523 0.162872739245624 no 543 0.169740254784311 871 821356 YKL052C ASK1
SGTC_2899 9053889 58.44 µM 0.954730756307436 0.162990193421532 no 544 0.169856936032637 848 6470052
SGTC_1105 epirubicin 18.1 µM 0.953353077436925 0.163341190223239 no 545 0.170205603570382 826 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2881 9058953 51.95 µM 0.952096393272911 0.163661788637657 no 546 0.170524049012924 915 17122249
SGTC_1102 cgs 12066b 26.1 µM 0.947038782184921 0.164956186290786 no 547 0.171809508606779 815 6438352 A 5-HT1B full agonist.
SGTC_435 c-PAF 6.7 µM 0.946825311702122 0.165010965342764 no 548 0.171863900759123 874 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_3297 9117502 71.43 µM 0.944595476815165 0.165583871345399 no 549 0.172432718569387 876 7453720
SGTC_2058 5236698 133 µM 0.942677409295952 0.166077703665035 no 550 0.172922965909467 828 766665
SGTC_1280 0880-0253 10.1 µM 0.941189504565848 0.166461439480339 no 551 0.173303877127953 863 6836607
SGTC_2447 5741742 33.78 µM 0.940567840835443 0.166621938132452 no 552 0.173463184333231 882 1776504
SGTC_2065 5221596 34.26 µM 0.940143652439734 0.166731510698644 no 553 0.173571940098971 824 788581
SGTC_2459 5811157 9.22 µM 0.937411390234276 0.167438398225759 no 554 0.174273492085398 901 2870684 YBR192W RIM2
SGTC_1261 0712-0010 12.7 µM 0.936016487458643 0.167800029249161 no 555 0.174632349434114 896 2840123
SGTC_1407 3909-7909 12.3 µM 0.934882985365807 0.168094261755722 no 556 0.174924303263646 908 4411780
SGTC_187 1488-2104 32.728 µM 0.932196252910273 0.168793004283335 no 557 0.17561755580587 912 2852859
SGTC_1722 st034304 3.6505 µM 0.9321817680718 0.168796776428049 no 558 0.175621298013718 857 4036148 YLR033W RSC58
SGTC_696 1560-0013 611 µM 0.930966123490055 0.169113547877473 no 559 0.175935544034713 883 1650269
SGTC_2740 felodipine 17.08 µM 0.929943934920358 0.169380204006139 no 560 0.176200056782115 812 3333 L-type calcium channel blocker
SGTC_1835 st008666 49.2 µM 0.926858082475933 0.170186839651772 no 561 0.177000111732114 773 690455
SGTC_2640 pentamidine 10.38 µM 0.924547706550082 0.170792375894329 no 562 0.177600612571456 946 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_415 dibenzyl ketone 100 µM 0.922638611322933 0.17129377786966 no 563 0.178097783550225 893 7593
SGTC_1949 st076024 69.1 µM 0.919329635033952 0.172165069236552 no 564 0.178961590807668 914 2921930
SGTC_719 2810-4230 27.3 µM 0.916514675618279 0.172908502720221 no 565 0.179698506871328 869 721079
SGTC_689 0833-0039 98 µM 0.91612824182773 0.173010719706119 no 566 0.179799818328485 917 5374726
SGTC_1675 st018485 24.5 µM 0.915906906433207 0.173069283259748 no 567 0.179857862049767 880 3323024
SGTC_1337 1486-1011 40.3 µM 0.91491373033879 0.173332225050536 no 568 0.180118460682671 919 X1337
SGTC_2248 tofa 1.1 µM 0.914610858321807 0.173412460514952 no 569 0.18019797815448 863 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1941 st076221 61.8 µM 0.914365994316565 0.173477346044033 no 570 0.180262282029957 927 2828568
SGTC_637 1181-0519 7.26 µM 0.913755295072388 0.173639240100817 no 571 0.180422720841878 954 6252091 YGR060W ERG25
SGTC_612 0302-0167 22.4 µM 0.913405126345319 0.173732111851937 no 572 0.180514755219855 967 235821
SGTC_1324 1418-0026 34.4 µM 0.908495591773436 0.175037544578007 no 573 0.181808220865402 918 1372513
SGTC_998 3996-0085 177 µM 0.906734305448895 0.175507378935141 no 574 0.182273658765851 962 715391
SGTC_2408 sulbentine 18.36 µM 0.906577424643886 0.175549266624349 no 575 0.182315152206207 878 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2158 5657123 3.6195 µM 0.906491513728602 0.175572207804949 no 576 0.182337877304955 912 2858827
SGTC_1223 0764-0573 147 µM 0.906013312658932 0.175699938719458 no 577 0.182464403079502 938 1609797
SGTC_427 1354-0053 47.3 µM 0.905499948661889 0.175837127412184 no 578 0.182600293532337 876 6813657
SGTC_2618 avocadyne 43.43 µM 0.904661303711694 0.176061388382341 no 579 0.182822423672334 897 3015189
SGTC_2478 5763493 32.33 µM 0.90392594332568 0.17625817908945 no 580 0.183017335771626 916 1365576 YLR208W SEC13
SGTC_139 0099-0334 718.624 µM 0.900395700774083 0.177204848769677 no 581 0.183954853956449 1037 97690
SGTC_1743 st037606 46.3785 µM 0.897063017153338 0.178101482052358 no 582 0.184842645793708 883 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_877 0771-0151 33.1 µM 0.895262116859567 0.178587188858649 no 583 0.185323493090294 930 6166523
SGTC_3018 9082602 49.47 µM 0.895101104834739 0.178630654747144 no 584 0.185366521709574 946 17332089
SGTC_1057 3448-5381 134 µM 0.894335015812837 0.17883755501589 no 585 0.185571335174508 939 5497911
SGTC_1701 st028638 40.4 µM 0.893439907262375 0.179079491032497 no 586 0.185810819761417 939 3490878
SGTC_2499 avocadenofuran 51.48 µM 0.893363638879603 0.179100114884432 no 587 0.185831234080585 916 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2729 fluphenazine 10.66 µM 0.889581765681307 0.180124650651794 no 588 0.18684525039783 948 3372 An atypical antipsychotic.
SGTC_2136 5328288 199.296 µM 0.888852113330522 0.180322741124161 no 589 0.187041282075768 811 262395
SGTC_450 aminopyrene 156 nM 0.888161669344492 0.180510312896464 no 590 0.187226896969459 913 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1499 4480-0877 67.3 µM 0.887961301170158 0.180564769489154 no 591 0.187280784085321 873 2861909
SGTC_1511 0906-3109 28.5 µM 0.884450916591207 0.181520502100779 no 592 0.188226423757231 1024 2882180
SGTC_986 1493-0483 84 µM 0.884270634267271 0.181569670856794 no 593 0.18827506824821 907 40079
SGTC_1711 st032263 62.8 µM 0.883891413208225 0.181673123772834 no 594 0.188377416490815 906 3958979
SGTC_1029 k015-0030 64.7 µM 0.883001410913851 0.181916064529297 no 595 0.188617754599647 900 2208316
SGTC_1822 st052468 42 µM 0.882328169473598 0.182099971755276 no 596 0.188799683674814 930 2873678
SGTC_341 1486-1430 230 µM 0.880648567741121 0.182559289685445 no 597 0.189254031277097 928 2054753 YPL210C SRP72
SGTC_3042 9091578 49.47 µM 0.879564839007476 0.182856038909308 no 598 0.189547546779238 915 25236497
SGTC_2519 cryptotanshinone 88.04 µM 0.87840808069122 0.183173117250367 no 599 0.189861150349416 939 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2044 5102272 200 µM 0.877735952367593 0.183357511376016 no 600 0.190043514498902 861 592666
SGTC_1161 k007-0610 110 µM 0.87753277844271 0.183413273620645 no 601 0.190098661524526 1020 5843850
SGTC_2788 5282734 71.43 µM 0.875964476247644 0.183844058805401 no 602 0.190524672995937 981 743706
SGTC_626 0214-0009 33 µM 0.875591466627308 0.183946610718233 no 603 0.190626083040891 974 3437874
SGTC_2796 7949634 45.45 µM 0.875559581671743 0.183955378533717 no 604 0.190634753133772 872 2971588
SGTC_2068 5226020 147 µM 0.875491573254485 0.183974080550595 no 605 0.190653246654302 1006 1810509
SGTC_870 0573-2213 57.6 µM 0.875384667299318 0.184003481613233 no 606 0.190682319803486 955 3916321
SGTC_2103 5378138 10 µM 0.875166271354414 0.184063553522794 no 607 0.190741721190063 1010 244142
SGTC_1427 4048-4900 550 nM 0.875091734810211 0.184084058311906 no 608 0.190761996940496 972 24132586
SGTC_29 0299-0004 12.984 µM 0.874841705414956 0.184152851064959 no 609 0.190830020667953 852 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1917 st066507 28.5 µM 0.874786307408856 0.184168095363396 no 610 0.190845094425121 935 3156428
SGTC_1735 st034310 56.75 µM 0.873956578505405 0.184396512265709 no 611 0.19107095045831 917 871153
SGTC_2076 5212012 200 µM 0.870724289337033 0.185288011899354 no 612 0.191952356434276 851 604802
SGTC_52 0329-0193 875 nM 0.869984304161781 0.185492483526702 no 613 0.19215449093336 901 3739292
SGTC_2876 9059903 25.97 µM 0.869764309920154 0.185553299012099 no 614 0.192214609708006 975 6916095
SGTC_202 3594-0513 34.79 µM 0.86943447217752 0.185644502953789 no 615 0.192304767444121 934 708429
SGTC_2095 5432005 200 µM 0.869416031811416 0.18564960274865 no 616 0.192309808690779 898 783734
SGTC_512 prima-1 270 µM 0.867561116282423 0.186163034926513 no 617 0.192817320341133 990 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2207 7258803 200 µM 0.866339849765378 0.186501555912605 no 618 0.193151909574135 916 3666799
SGTC_2402 5553605 200 µM 0.864762332142189 0.18693938946093 no 619 0.193584624811492 976 6758546
SGTC_1393 3470-5649 58.2 µM 0.860582734488954 0.188102490982164 no 620 0.194733949241321 861 4108395
SGTC_2979 9012552 45.46 µM 0.859149794075435 0.188502276624466 no 621 0.195128939180286 920 17100905
SGTC_765 1319-0117 244 µM 0.858126991523682 0.188787955386545 no 622 0.195411172258721 970 3487746 YGL099W LSG1
SGTC_1349 flufenamic acid 69 µM 0.857511416733624 0.188960019997604 no 623 0.195581153998539 923 3371 A non-steroidal anti-inflammatory.
SGTC_421 streptovitacin 30 mM 0.857320255766023 0.189013472699149 no 624 0.195633958494808 983 91467 include heat shock
SGTC_2005 4024620 188 µM 0.856993125850757 0.189104966836088 no 625 0.195724341843604 952 236743
SGTC_2666 tannic acid 100 µM 0.855457991004402 0.189534689035052 no 626 0.196148825643014 994 16134267 A thiamine antagonist.
SGTC_3015 9080845 49.47 µM 0.853725509159223 0.190020374551076 no 627 0.196628548307908 1036 5296973
SGTC_2520 obtusaquinone 4.71 µM 0.85358958846785 0.190058511014336 no 628 0.196666214669295 976 5967872
SGTC_3131 9127911 49.47 µM 0.852506993567452 0.190362432099107 no 629 0.196966379537363 916 45595681
SGTC_3203 9113543 49.47 µM 0.852098166453652 0.190477281329671 no 630 0.197079804782069 940 17018012
SGTC_1076 itraconazole 331 nM 0.850594357386709 0.190900102919585 no 631 0.197497362490407 1031 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1660 st012960 28.1 µM 0.850497198875692 0.19092744048125 no 632 0.197524358557314 932 24207266
SGTC_1816 st051957 91.6 µM 0.850180525816168 0.19101655968107 no 633 0.197612363524565 975 674121
SGTC_2387 9077560 195.08 µM 0.849004727947681 0.191347679847669 no 634 0.197939330727192 939 5303272
SGTC_1485 3909-9022 254 µM 0.847059524609155 0.191896246539285 no 635 0.198480972026925 1044 714516
SGTC_1235 benzylparaben 21.5 µM 0.846214438159651 0.192134868991797 no 636 0.198716564451728 924 7180
SGTC_2980 9014342 25.29 µM 0.844231605707063 0.192695462846149 no 637 0.199269998214207 891 2996599
SGTC_1385 3091-4834 14.1 µM 0.843869440045284 0.192797963531548 no 638 0.199371183420066 932 4072814
SGTC_709 3807-1509 243 µM 0.842734682506811 0.193119339994616 no 639 0.199688422775249 989 1886677 YPL242C IQG1
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.839974198314229 0.193902505461557 no 640 0.20046142668175 948 17037758
SGTC_206 4546-0025 72.014 µM 0.838565571788608 0.194302885810874 no 641 0.200856568559942 1033 6620745 YIL048W NEO1
SGTC_2477 5967686 25.23 µM 0.837762891860304 0.194531260183008 no 642 0.201081941796869 978 776118
SGTC_1505 k297-0037 20.6 µM 0.837218446741782 0.194686255855049 no 643 0.201234895196495 966 4089396
SGTC_438 sphingosine 6.67 µM 0.836772769533009 0.194813189636555 no 644 0.201360153193108 946 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1986 st071812 45 µM 0.836407389661463 0.194917291392289 no 645 0.201462878401235 957 11838594
SGTC_2878 9043973 25.97 µM 0.836369331057839 0.194928136757345 no 646 0.201473580243431 983 6465167
SGTC_1481 3346-2004 36 µM 0.835750265685056 0.195104600165015 no 647 0.201647705402596 1027 2770522
SGTC_2787 5284540 71.43 µM 0.835396887851793 0.195205373363914 no 648 0.201747140753947 961 736958
SGTC_2731 amoxapine 43.43 µM 0.832437711386044 0.196050486305559 no 649 0.202580961637974 988 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3055 9094636 49.47 µM 0.830482916321232 0.196609972685322 no 650 0.203132901409977 984 25236176
SGTC_3028 9087778 49.47 µM 0.828630391821665 0.197141079671558 no 651 0.203656792533538 1025 17217395
SGTC_2641 levomentholum 100 µM 0.828515599170834 0.19717401853298 no 652 0.203689282207898 968 16666
SGTC_42 0133-0086 60.653 µM 0.828176225612965 0.197271418617876 no 653 0.203785352912948 974 162923 Model of phenazepam hydroxylation.
SGTC_2600 tangeritin 87.95 µM 0.826799341587253 0.197666882310335 no 654 0.204175401650204 952 68077 A bioactive flavone.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.825674263023355 0.197990378787344 no 655 0.204494447866223 931 6857784
SGTC_2551 apiole 73.87 µM 0.824349703894853 0.198371641918264 no 656 0.204870442174934 888 10659 A possible DNA adduct former.
SGTC_1628 st004252 77.7 µM 0.822618310798965 0.198870676271956 no 657 0.205362541261955 1008 692968
SGTC_495 decylubiquinone 155 µM 0.821424126297111 0.199215313108455 no 658 0.205702362874805 943 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1242 0402-0103 60.1 µM 0.820009786582259 0.199623950829527 no 659 0.206105264065237 960 432868
SGTC_226 1,3-diallylurea 8.28947 mM 0.819411222743284 0.199797042518716 no 660 0.206275917020081 989 74537 YKL182W FAS1
SGTC_3087 9117406 49.47 µM 0.818854425372478 0.199958137272348 no 661 0.206434737349219 1005 42546093
SGTC_423 5-fluorouracil 457 µM 0.818793427497531 0.199975790157297 no 662 0.206452140724727 953 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_440 fluspirilene 35.1 µM 0.818157044718691 0.200160016255003 no 663 0.206633759680183 1006 3396 An atypical antipsychotic.
SGTC_1724 st037281 8.293 µM 0.816328928364164 0.200689803745059 no 664 0.207156016663677 1001 574124 YDL195W SEC31
SGTC_547 1120-0019 610 nM 0.816169194674793 0.200736134468152 no 665 0.207201686506623 984 3676939
SGTC_1027 k015-0025 8.67 µM 0.815819367615354 0.200837624157523 no 666 0.207301727201116 1037 3598955
SGTC_952 1185-0122 232 µM 0.815691339346852 0.200874774632127 no 667 0.207338346820862 1032 678600
SGTC_1121 fusaric acid 630.51 nM 0.814185843046155 0.201311939780405 no 668 0.207769247177419 990 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2680 butyl paraben 22.24 µM 0.809578889314964 0.202653242873937 no 669 0.209091122622378 1046 7184 An antifungal and steroid mimetic.
SGTC_1120 ficusin 1.78878 µM 0.809076087776958 0.202799954862851 no 670 0.209235690842382 1023 6199 A DNA cross-linker.
SGTC_3260 9137109 49.47 µM 0.808876378076149 0.202858245572327 no 671 0.209293128779457 903 17478346
SGTC_1880 MG-132 525 µM 0.807674581529894 0.203209233871998 no 672 0.209638969961551 980 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2310 7668677 200 µM 0.802691798451445 0.204668333086442 no 673 0.211076447264469 1018 2197143
SGTC_536 3852-0578 10.6 µM 0.801947158923633 0.204886918568281 no 674 0.211291762557179 1063 2869208
SGTC_193 1273-0060 1.558 µM 0.799091685993062 0.205726415230261 no 675 0.212118625067612 927 2847393 YHR072W ERG7
SGTC_872 0588-0139 234 µM 0.795752202673421 0.20671079404646 no 676 0.213088039099606 1084 2047100
SGTC_492 tmb-8 126 µM 0.795397994704967 0.206815367201395 no 677 0.213191013026393 922 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1556 plumbagin 1.48 µM 0.79525516898348 0.20685754263301 no 678 0.213232542959076 977 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3036 9090181 49.47 µM 0.795183093697864 0.206878827890835 no 679 0.213253502331965 1036 25236586
SGTC_1326 1431-2094 10.8 µM 0.795113974368616 0.206899241413905 no 680 0.21327360324606 1030 616278
SGTC_727 3032-0951 202 µM 0.794804451030323 0.206990669853922 no 681 0.213363630719673 1004 3652836
SGTC_2047 4141938 200 µM 0.792858750535438 0.207565947160966 no 682 0.213930061251554 995 3807862
SGTC_265 mycophenolic acid 32.932 µM 0.792850097309208 0.20756850773348 no 683 0.213932582324603 1109 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2751 anetholtrithion 17.25 µM 0.79276495443746 0.207593703320053 no 684 0.213957389185642 1013 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1817 st052116 64.4 µM 0.79251779442219 0.207666853461876 no 685 0.214029410150383 1027 4361398
SGTC_3027 9089541 49.47 µM 0.791990376791535 0.207823000311387 no 686 0.214183143698545 1061 9943819
SGTC_2396 5342950 42.78 µM 0.791381816903241 0.208003256209346 no 687 0.214360608688576 1051 1886677
SGTC_1952 st077036 64.1 µM 0.791043891871344 0.2081033897016 no 688 0.214459189501374 1099 2937007
SGTC_3147 9097027 49.47 µM 0.789758709769104 0.208484472908867 no 689 0.214834348538059 1064 25236841
SGTC_220 paclitaxel 373.376 µM 0.785907062807689 0.209629028216429 no 690 0.215960968248663 989 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2234 tolnaftate 200 µM 0.785199928217879 0.209839561097649 no 691 0.216168178778117 1039 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1554 st069299 38.7 µM 0.784624845502551 0.210010870209701 no 692 0.216336779211691 1088 24207999
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.783218767498229 0.210430067144982 no 693 0.216749327922711 1059 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_533 1222-0222 6.71 µM 0.783055029356758 0.210478914643988 no 694 0.216797398881093 1102 3982874
SGTC_3070 9117005 49.47 µM 0.782701732710389 0.210584335222018 no 695 0.216901142250428 1051 8779016
SGTC_3121 9125696 49.47 µM 0.782678947258878 0.210591135261558 no 696 0.21690783404191 1115 1235365
SGTC_2050 5263056 171 µM 0.781240081778691 0.211020807995473 no 697 0.217330651824902 1096 763468 YGL055W OLE1
SGTC_1238 0333-0287 48.8 µM 0.780829680744793 0.211143455716829 no 698 0.217451337390791 1077 7226
SGTC_1772 st048439 82.2 µM 0.779893043578708 0.211423524717035 no 699 0.217726916711498 1046 2927068 YDL195W SEC31
SGTC_3328 9140624 29.0385 µM 0.77819838105974 0.211930807582225 no 700 0.218226035542137 1088 4904392
SGTC_1676 st018489 23.4 µM 0.777429404260455 0.21216122890342 no 701 0.218452734969224 1028 3696235
SGTC_698 k064-0052 127 µM 0.777000891904871 0.212289694718814 no 702 0.21857912205951 1102 5088751
SGTC_2160 5660466 132.927 µM 0.776543483565451 0.21242687355465 no 703 0.218714078283777 1017 2859134
SGTC_2890 9046729 58.44 µM 0.775015828823694 0.212885399308782 no 704 0.219165153174459 1000 903329
SGTC_2969 9091408 28.7 µM 0.772950513171258 0.213506221511724 no 705 0.219775834202043 1006 4286311
SGTC_1383 3049-0032 20.7 µM 0.772727739107587 0.213573249118031 no 706 0.219841763267549 1107 712864
SGTC_2818 7996756 12.99 µM 0.772119676620582 0.213756263568763 no 707 0.220021774620294 1071 2241621
SGTC_48 0382-0018 55 µM 0.772095629963398 0.213763503000895 no 708 0.220028895151606 1141 762596
SGTC_861 0443-0273 110 µM 0.770605666134265 0.214212346606756 no 709 0.220470350836528 1085 6149169
SGTC_2612 dictamnine 15.46 µM 0.770546402864515 0.214230210679598 no 710 0.220487920214017 1020 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1278 0874-0585 172 µM 0.77033617045635 0.214293589250069 no 711 0.220550252853839 1082 766306
SGTC_2546 rhodinyl acetate 100 µM 0.769059583547412 0.214678674850946 no 712 0.220928969900047 1087 6708682
SGTC_35 0133-0054 64.071 µM 0.768952349413745 0.214711040591993 no 713 0.220960799319031 1054 99677
SGTC_906 1165-0455 526 µM 0.768666517425628 0.214797325145983 no 714 0.221045653280374 1075 3252859
SGTC_1287 0971-0001 34.6 µM 0.766366817311815 0.215492271959256 no 715 0.221729035599225 1092 4665869
SGTC_2997 9067075 71.4286 µM 0.765382916354598 0.215789995057536 no 716 0.22202178136333 1080 27209819
SGTC_781 4335-2806 94.4 µM 0.764452876146677 0.216071639252396 no 717 0.222298704387747 1165 845254
SGTC_1064 honokiol 6.76 µM 0.764027973453393 0.216200383414459 no 718 0.222425286339195 1079 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1026 k007-1105 30.6 µM 0.763706148362241 0.216297924946979 no 719 0.222521187992767 1083 7066794
SGTC_1965 Pectolinarigenin 58.4 µM 0.762872309727651 0.216550770455464 no 720 0.222769775799726 1126 5320438 An anti-inflammatory.
SGTC_2389 9091542 195.52 µM 0.761970672742843 0.216824366834227 no 721 0.223038753955406 1055 3626624 YOL127W RPL25
SGTC_3271 9137798 49.47 µM 0.761762995467624 0.216887413574471 no 722 0.223100734853537 1033 6498326
SGTC_2357 9067248 200 µM 0.760749871362543 0.217195130059761 no 723 0.223403240450383 1069 9150235
SGTC_2959 9079155 11 µM 0.760519216749654 0.21726522208161 no 724 0.223472143498749 1093 16189457
SGTC_3211 9128781 49.47 µM 0.759598731942514 0.217545071856552 no 725 0.223747238672778 995 17194361
SGTC_2466 5983409 37.09 µM 0.757746051296089 0.218108962178236 no 726 0.224301512243344 1041 2879657
SGTC_3167 9103034 49.47 µM 0.756882271905224 0.218372153699552 no 727 0.224560198635104 1120 5127859
SGTC_2529 gangaleoidin 93.61 µM 0.756247539665282 0.218565671651175 no 728 0.224750397364906 1119 4565183
SGTC_984 1492-0255 2.91 µM 0.755269938752923 0.218863916889042 no 729 0.225043515973752 1038 1585198
SGTC_569 4130-2812 160 µM 0.753201364057519 0.219495766311903 no 730 0.225664459897018 1013 743552
SGTC_982 1491-0518 27.5 µM 0.753001775261082 0.219556786406798 no 731 0.225724423616929 1050 3091256
SGTC_117 lucigenin 22.078 µM 0.751682668199516 0.219960320683664 no 732 0.226120957837592 1138 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2862 9027634 71.43 µM 0.751475058913929 0.220023870159662 no 733 0.226183402699038 1082 5012562
SGTC_3102 9121669 49.47 µM 0.748683273932386 0.220879461831527 no 734 0.227024063621888 1124 41905072
SGTC_3095 9117207 49.47 µM 0.746301240228346 0.221610981592056 no 735 0.227742731209312 1068 17015229
SGTC_1753 st043925 64 µM 0.745739612821113 0.221783658198169 no 736 0.227912362444501 1131 670181
SGTC_3341 9147222 25.867 µM 0.745176960010615 0.22195672711731 no 737 0.228082374643422 1077 1939759
SGTC_2567 aureobasidin a 60 nM 0.745125118566629 0.221972677140289 no 738 0.228098042736201 1115 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2143 5623677 140.463 µM 0.744917176745244 0.222036661040621 no 739 0.228160895288681 1102 5375313
SGTC_1416 3966-0321 25.3 µM 0.744689880767647 0.222106612276951 no 740 0.22822960897183 1149 582530 YLR208W SEC13
SGTC_2566 crystal violet carbinol 226 nM 0.743601561639824 0.222441721051061 no 741 0.228558779098021 1073 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_253 dyclonine 31.25 µM 0.743192333688274 0.222567802656709 no 742 0.228682622055663 1168 3180 An oral anasthetic.
SGTC_162 k030-0015 37.8 µM 0.741036823161602 0.223232579550133 no 743 0.229335556827223 1172 1809920 YMR134W ERG29
SGTC_344 k064-0035 6.43 µM 0.74040125516162 0.22342880941021 no 744 0.229528278723721 1102 5088750
SGTC_1361 1608-0041 5.61 µM 0.737938152495944 0.224190211995805 no 745 0.230276016617386 1129 X1361
SGTC_2552 juarezic acid 87.02 µM 0.73698200344773 0.224486176546647 no 746 0.230566646790222 1223 1549512
SGTC_200 k038-0079 37.545 µM 0.736569351885991 0.224613976382341 no 747 0.23069213926874 1096 3436683
SGTC_827 3253-0474 693 µM 0.736513884197578 0.224631158093015 no 748 0.230709010592295 1146 5402065
SGTC_91 0417-1751 58.384 µM 0.735846949291562 0.224837806689837 no 749 0.230911922737735 1263 6795624
SGTC_830 4076-0286 57.8 µM 0.733642689599739 0.225521558889204 no 750 0.231583267890005 1191 6866659
SGTC_609 0986-0026 86.3 µM 0.732428892208332 0.225898575700692 no 751 0.231953414720949 1116 2848610
SGTC_991 3996-0057 64.7 µM 0.731409745184261 0.226215407349553 no 752 0.232264457298363 1094 715343
SGTC_163 TUB2.036 7.546 µM 0.730377999180175 0.226536411351285 no 753 0.232579581330965 1192 15992207 YJR013W GPI14
SGTC_1318 1280-3875 124 µM 0.730315247293025 0.226555943447976 no 754 0.232598755174289 1122 373245
SGTC_1716 st033144 30.6155 µM 0.728496627584286 0.227122418270436 no 755 0.23315481616406 1154 674617
SGTC_939 1165-0479 45.3 µM 0.726833590299476 0.227641129509047 no 756 0.233663951596328 1117 1377347
SGTC_3099 9120367 49.47 µM 0.725842870385114 0.22795045769101 no 757 0.233967551187867 1185 24824940
SGTC_1274 0865-0114 173 µM 0.724048064508788 0.22851144389556 no 758 0.234518113744596 1164 870624
SGTC_1216 1165-0504 9.65 µM 0.723232238940685 0.22876669525914 no 759 0.234768607623953 1148 6304004
SGTC_3286 9117135 37.221 µM 0.722789159183421 0.228905390850521 no 760 0.234904714308065 1133 3438150
SGTC_518 1021-0119 62.6 µM 0.72187906190592 0.229190423140115 no 761 0.235184417680877 1090 1097762
SGTC_1023 4482-3888 16 µM 0.721871274672449 0.229192862873065 no 762 0.235186811751833 1142 3303168
SGTC_1939 st074455 53.6 µM 0.718187225668071 0.230348703986907 no 763 0.236320926687273 1167 1644229
SGTC_1936 st074407 74.3 µM 0.717681151415516 0.230507734985247 no 764 0.236476953850413 1200 809813
SGTC_930 2810-3379 265 µM 0.717330015540229 0.230618113517403 no 765 0.236585245450642 1203 1015764
SGTC_279 1273-0055 2.93 µM 0.716952657884335 0.230736767706051 no 766 0.236701654356433 1207 2847562
SGTC_3183 9108214 49.47 µM 0.716694539993759 0.23081794845954 no 767 0.236781297810576 1070 4974831
SGTC_489 paxilline 115 µM 0.716011214155486 0.231032938514262 no 768 0.236992212249836 1166 105008 A toxic potassium channel blocker.
SGTC_1943 st076331 65.2 µM 0.715983145310632 0.231041772008932 no 769 0.237000878149311 1234 24208415
SGTC_2229 7354935 190 µM 0.715251650039259 0.231272046005841 no 770 0.237226779427607 1128 318112
SGTC_2063 5246145 200 µM 0.715127753575016 0.231311061166499 no 771 0.23726505299696 1197 711240
SGTC_3029 9088683 49.47 µM 0.714574548418171 0.23148531098697 no 772 0.237435988156072 1193 25236615
SGTC_2279 7948423 32.93 µM 0.713582305530161 0.231798033185026 no 773 0.237742751127964 1145 1247112
SGTC_1185 1319-0113 81.3 µM 0.713563918017999 0.23180383054198 no 774 0.237748437883729 1157 4672763
SGTC_381 3461-2219 42.7 µM 0.711277054592169 0.232525479915679 no 775 0.238456283744676 1159 2883159
SGTC_3119 9125183 49.47 µM 0.711074949425282 0.232589316842787 no 776 0.238518896186097 1031 22695334
SGTC_1377 2944-0135 198 µM 0.710292672352313 0.232836498657513 no 777 0.238761331446105 1201 1894137
SGTC_1754 st042065 16.137 µM 0.709803684347057 0.232991081876462 no 778 0.238912942019195 1147 1126236 YIL048W NEO1
SGTC_946 3434-1334 87.4 µM 0.708917967958721 0.233271227453509 no 779 0.239187692091272 1134 4047976
SGTC_2262 9014885 67.46 µM 0.707759025513154 0.233638074589081 no 780 0.239547457763608 1125 6457424
SGTC_829 1635-0120 117 µM 0.707373941931488 0.233760038210375 no 781 0.239667063009823 1207 285054
SGTC_959 1222-0044 107 µM 0.706170876984918 0.234141300030553 no 782 0.240040939506062 1171 6083612
SGTC_2358 9037157 4 µM 0.704980074152482 0.234519014715621 no 783 0.240411318233204 1187 2388925
SGTC_1563 conessine 56.1 µM 0.702045997426338 0.235451121049458 no 784 0.241325239200727 1262 441082 An anti-amoebic, histamine inhibitor.
SGTC_3136 9095672 49.47 µM 0.702019621860151 0.235459509380167 no 785 0.24133346334698 1042 17217380
SGTC_792 4534-1957 155 µM 0.701308783706665 0.235685642289723 no 786 0.241555166624709 1153 1717904
SGTC_323 4013-0906 34.3 µM 0.700839533436542 0.235834986502962 no 787 0.241701581649605 1211 2910086
SGTC_1736 st036774 51 µM 0.700526103916084 0.235934768051713 no 788 0.241799404459337 1212 1272247
SGTC_1225 1216-0074 20.6 µM 0.700123702733119 0.236062908193221 no 789 0.241925027230517 1181 4241466
SGTC_2377 9073351 62.6 µM 0.697886743835685 0.236775941242619 no 790 0.242624012589557 1160 7337946 YHR072W ERG7
SGTC_1295 1013-0063 9.78 µM 0.697137064437315 0.237015167071657 no 791 0.242858510264496 1201 6826038
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.697045760035299 0.237044311759627 no 792 0.242887078408453 1164 756377
SGTC_1520 flindersine 88 µM 0.696706259519856 0.237152698799319 no 793 0.242993320337506 1262 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_561 1550-0330 72.9 µM 0.695720735626511 0.237467485839824 no 794 0.243301868577316 1169 6812934
SGTC_1356 1502-0781 85.8 µM 0.695060695621019 0.237678437971708 no 795 0.243508632522535 1167 567702
SGTC_2789 5281112 71.43 µM 0.694923827075789 0.237722194719449 no 796 0.24355151980286 1200 765948
SGTC_2247 cerulenin 830 nM 0.69305253863239 0.238320886929 no 797 0.244138290478661 1250 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_909 3448-9333 149 µM 0.692847073255535 0.238386672941713 no 798 0.244202763656277 1159 3344074
SGTC_1013 4112-3890 241 µM 0.692730862063531 0.238423885904915 no 799 0.244239233741665 1132 705171
SGTC_115 0527-0192 112.043 µM 0.692147335170758 0.238610790035317 no 800 0.244422403991287 1229 4233931
SGTC_2479 5617353 43.85 µM 0.691242802486866 0.238900670997905 no 801 0.244706484833643 1228 2731746
SGTC_1149 3909-7961 23.3 µM 0.691088448050506 0.238950157110411 no 802 0.244754979702629 1175 735261
SGTC_630 4356-0227 183 µM 0.690807376147494 0.239040283302777 no 803 0.244843299781511 1214 779312
SGTC_370 0180-0345 38.7 µM 0.69037893932669 0.239177698055716 no 804 0.244977958732431 1146 3989527
SGTC_1190 1486-1332 13 µM 0.689067875352514 0.239598470412365 no 805 0.245390277402123 1195 4150046
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.689041753398031 0.239606858085766 no 806 0.245398496326342 1209 2374 Ca(2+)-ATPase inhibitor.
SGTC_1632 st005650 90 µM 0.688800827375392 0.239684226192433 no 807 0.24547430745665 1199 2759605
SGTC_2437 5741531 144.16 µM 0.68854197526928 0.239767366058103 no 808 0.245555773329586 1265 2262990
SGTC_669 0108-0021 26.2 µM 0.688359588520504 0.239825955712463 no 809 0.24561318276399 1286 17201
SGTC_1775 st081588 35.1725 µM 0.685331312383779 0.240799895239578 no 810 0.246567438529347 1248 1426443 YGL099W LSG1
SGTC_2797 7859098 81.82 µM 0.685236229263249 0.240830510220853 no 811 0.246597432788606 1243 972681
SGTC_1802 st050112 57.9 µM 0.684589551553326 0.241038784482696 no 812 0.246801481075086 1212 4662563
SGTC_3273 9137859 49.47 µM 0.68379450127156 0.241294978988541 no 813 0.247052469657182 1272 2377234
SGTC_1071 trifluoperazine 6.31 µM 0.682764033869624 0.241627253625305 no 814 0.247377979900631 1260 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3159 9100096 49.47 µM 0.680159279942928 0.242468264050436 no 815 0.248201806284292 1193 25236875
SGTC_1787 fluconazole 80 µM 0.679741901400547 0.242603172471254 no 816 0.248333949809692 1148 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2872 9044037 25.97 µM 0.677619852163576 0.243289706378753 no 817 0.249006377795429 1211 6465195
SGTC_1651 st011928 86.1 µM 0.676917197400798 0.243517263273183 no 818 0.249229246049546 1232 720198
SGTC_2167 5876490 200 µM 0.676882263273469 0.243528579796465 no 819 0.249240329234116 1259 686534
SGTC_2263 7948595 193.29 µM 0.674647963401054 0.244252946186379 no 820 0.249949726232665 1224 2971371
SGTC_2290 7904846 200 µM 0.674439561278433 0.244320569920872 no 821 0.250015949132183 1251 2962154
SGTC_2240 6690706 185.951 µM 0.673206057810462 0.244721032035915 no 822 0.250408103904931 1175 805876
SGTC_705 1124-0212 310 µM 0.671552852747451 0.245258305794732 no 823 0.250934200840359 1233 9554485
SGTC_1405 3909-7894 12 µM 0.670511941036365 0.245596915900874 no 824 0.251265748462725 1239 7104060
SGTC_1260 0700-1617 7.75 µM 0.669457414537838 0.245940210799952 no 825 0.251601868663243 1238 2853078
SGTC_1591 genipin 88.4 µM 0.668758448139119 0.246167897023482 no 826 0.25182478831806 1239 442424 A DNA cross-linking agent.
SGTC_1313 1220-0047 237 µM 0.664599465205308 0.247525007575576 no 827 0.253153355703779 1262 3528706
SGTC_1184 1269-1718 139 µM 0.662145396991288 0.248327661643125 no 828 0.253939022089811 1264 5403821
SGTC_1046 2001-0062 216 µM 0.660204033324364 0.248963606672776 no 829 0.254561452170993 1204 739778
SGTC_1800 st050079 29.0735 µM 0.66010313897398 0.248996680961651 no 830 0.254593822234229 1220 3645560
SGTC_327 1273-0057 3.96 µM 0.65930580270598 0.249258138873186 no 831 0.254849708472615 1192 3108138
SGTC_2087 5276107 200 µM 0.65848305402963 0.249528082834341 no 832 0.255113891274783 1235 144405
SGTC_490 phenamil 164 µM 0.657908867208958 0.249716565603468 no 833 0.255298346234451 1195 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1041 0206-0046 107 µM 0.657828111439462 0.249743080584229 no 834 0.255324294256898 1265 50494
SGTC_1940 st075990 51.1 µM 0.657665640877469 0.24979642995613 no 835 0.255376502626437 1343 1084979
SGTC_2783 7738165 71.43 µM 0.657618581768674 0.24981188357099 no 836 0.255391625665381 1191 17201110
SGTC_1644 st010134 20.9 µM 0.657500040367831 0.24985081331404 no 837 0.255429722515948 1244 3818134
SGTC_3236 9132701 49.47 µM 0.657386293939617 0.249888171385383 no 838 0.255466281149284 1224 24282524
SGTC_125 0133-0007 11.75 µM 0.657188481814412 0.249953146459855 no 839 0.255529865401205 1322 26541
SGTC_3047 9092122 49.47 µM 0.656711367395235 0.250109900456942 no 840 0.255683261919888 1224 17173831
SGTC_868 0527-0199 213 µM 0.655977126789572 0.25035123405337 no 841 0.255919420692515 1231 2849450
SGTC_3193 9111931 49.47 µM 0.653576599455378 0.251141111226539 no 842 0.256692312190708 1309 17087244
SGTC_1846 st056244 14.8 µM 0.652480632381624 0.251502169533321 no 843 0.257045581498038 1277 5393182
SGTC_2809 7964133 12.99 µM 0.652422354399242 0.25152137646422 no 844 0.257064373650349 1273 1253665
SGTC_1865 st057639 52.2 µM 0.650281441689236 0.252227503349059 no 845 0.257755221234374 1266 688818
SGTC_1834 st055981 52.8 µM 0.649564818647805 0.252464096968182 no 846 0.257986682230263 1319 471719 YDL150W RPC53
SGTC_3188 9110789 49.47 µM 0.649225787206678 0.252576069184414 no 847 0.258096223041377 1299 849217
SGTC_506 n9-isopropylolomoucine 153 µM 0.649222239821492 0.252577240920769 no 848 0.258097369326427 1270 6610355
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.648799552000321 0.252716879378887 no 849 0.258233973539101 1294 66535 A nucleotide analog.
SGTC_1391 3442-0225 151 µM 0.648757574721499 0.252730749142939 no 850 0.258247541797805 1244 5227075
SGTC_2041 5107442 45.335 µM 0.647747703511269 0.253064542705582 no 851 0.2585740724375 1269 793005
SGTC_1125 tnp00248 1.32998 µM 0.646940213289615 0.253331609885469 no 852 0.258835319170096 1355 24207736
SGTC_1389 3405-0187 19 µM 0.646195463017071 0.253578057898602 no 853 0.259076388706875 1234 799890
SGTC_1882 5615643 20 µM 0.644338631826826 0.254193056667258 no 854 0.2596779348551 1210 2253075
SGTC_751 0833-0568 350 µM 0.643058160610529 0.25461761518396 no 855 0.260093180824098 1308 6954252
SGTC_3304 9125678 46.087 µM 0.642590040648828 0.25477291970039 no 856 0.260245073568184 1271 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1135 dihydrocapsaicin 536.708 nM 0.642534290888537 0.254791418668741 no 857 0.260263165960012 1242 107982 A Capsaicinoid.
SGTC_735 3076-0345 636 µM 0.64232918718692 0.254859482535781 no 858 0.260329733555764 1322 2888990
SGTC_1785 bathophenanthroline 24 µM 0.639712260034346 0.2557287470487 no 859 0.261179841709058 1259 72812 An iron chelator.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.635879684644428 0.257004601404614 no 860 0.262427422433282 1386 6728940
SGTC_601 0986-0029 62.9 µM 0.635843635528596 0.257016617760931 no 861 0.262439171617133 1281 24747981
SGTC_63 0099-0242 26.702 µM 0.635374367097044 0.257173067027694 no 862 0.262592140881312 1278 3898502 YLR359W ADE13
SGTC_290 2043-6722 48.1 µM 0.633880717684243 0.257671363798265 no 863 0.263079335186368 1289 773758 YLR208W SEC13
SGTC_275 trichlorophene 5.69 µM 0.633098434964898 0.257932541218457 no 864 0.263334682118529 1333 62616
SGTC_1756 st041558 35.5 µM 0.632771587505089 0.258041705061651 no 865 0.263441406717837 1360 3955792
SGTC_2030 5175110 200 µM 0.63216747653468 0.258243535250092 no 866 0.263638723508205 1335 2831986
SGTC_336 4111-0029 111 µM 0.631323855442868 0.258525521323956 no 867 0.263914396019015 1247 3131175
SGTC_2790 5423970 71.43 µM 0.63111968394813 0.258593790991029 no 868 0.263981135807605 1344 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2356 9061756 188.97 µM 0.631117598612716 0.258594488321412 no 869 0.263981817508566 1281 20104043
SGTC_1616 st002734 56.1 µM 0.627585243318049 0.259777094355181 no 870 0.265137839065591 1278 4026101
SGTC_3109 9122853 49.47 µM 0.627080477381082 0.25994631380685 no 871 0.265303241753298 1369 1234709
SGTC_67 0335-0847 266 µM 0.626895969357129 0.260008183090973 no 872 0.265363714772539 1422 4552207 YOR254C SEC63
SGTC_1984 st072354 53.1 µM 0.626671963265238 0.260083307083164 no 873 0.265437142795189 1237 5762938
SGTC_2462 5162487 171.77 µM 0.626498685118435 0.260141426330399 no 874 0.265493949534593 1269 2259986
SGTC_1971 st069429 63.5 µM 0.626445768774933 0.26015917634281 no 875 0.26551129862334 1285 1246522 YGL099W LSG1
SGTC_3353 9151644 39.2805 µM 0.624986260593673 0.260648992927953 no 876 0.265990037804947 1300 4909158
SGTC_639 0833-0042 114 µM 0.624567557791945 0.26078959877252 no 877 0.266127458877391 1280 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2295 7971645 200 µM 0.622418405546772 0.2615119257598 no 878 0.266833390470266 1338 2978226 YKL099C UTP11
SGTC_1647 st011722 22.4 µM 0.622012274881726 0.261648540993326 no 879 0.26696689834204 1313 2854783
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.619441918663786 0.262514012359014 no 880 0.267812636670832 1303 16486 A toxic proline analog.
SGTC_1178 0988-0033 191 µM 0.617917002605619 0.263028162521689 no 881 0.268315025265493 1323 5392207
SGTC_3239 9133757 49.47 µM 0.616081543529927 0.263647699131244 no 882 0.268920351313426 1337 17036923
SGTC_2736 butenafine 14.65 µM 0.615703669415776 0.263775338230165 no 883 0.269045057532104 1312 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_201 4262-0159 12.803 µM 0.615012665493476 0.264008828435664 no 884 0.269273178059298 1292 1341029
SGTC_1982 st072467 71.9 µM 0.614931963137125 0.264036104626762 no 885 0.269299826583358 1307 3163533
SGTC_326 k292-0812 17.5 µM 0.614373807288824 0.264224792268768 no 886 0.269484170033667 1308 3579357
SGTC_2994 9053520 71.4286 µM 0.614197523817709 0.264284400127853 no 887 0.269542404731351 1339 4647384
SGTC_2627 acetyl isogambogic acid 100 µM 0.614024780855969 0.2643428174533 no 888 0.269599475949644 1266 6857789 A caspase activator and apoptosis inducer.
SGTC_924 2046-0044 21.3 µM 0.613429701198613 0.264544108744129 no 889 0.269796126081404 1299 3623589
SGTC_3185 9108267 49.47 µM 0.612837106735366 0.264744636864049 no 890 0.269992026304559 1278 4910486
SGTC_2090 5301565 104.445 µM 0.612618844336459 0.264818514177855 no 891 0.270064197548502 1344 2056344
SGTC_2251 lansoprazole 556 µM 0.612531118293969 0.264848210583666 no 892 0.270093208001631 1245 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2576 guaiol 23.12 µM 0.609388136671132 0.265913266261536 no 893 0.271133599711571 1317 227829
SGTC_2347 9049783 174.81 µM 0.60892843415661 0.26606922642584 no 894 0.271285938075552 1348 6467988 YPL169C MEX67
SGTC_254 nsc-64875 3.808 µM 0.608000012566844 0.266384346938641 no 895 0.271593732780255 1427 56993
SGTC_2426 5582046 32.21 µM 0.607000095972864 0.266723945031815 no 896 0.271925424224519 1362 2251934
SGTC_1101 ebselen 5.29 µM 0.606805549548177 0.266790043558153 no 897 0.271989982400442 1372 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2777 climbazole 1.536 µM 0.606713771546616 0.266821228657929 no 898 0.272020440606729 1328 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_507 nimesulide 162 µM 0.606709413530332 0.266822709507091 no 899 0.27202188693622 1375 4495 A COX2 inhibitor.
SGTC_3258 9138477 49.47 µM 0.604676820568156 0.267513834720407 no 900 0.272696876250472 1371 4970355
SGTC_1034 k072-0165 12.7 µM 0.604668650807133 0.267516614434725 no 901 0.27269959096436 1348 5835461
SGTC_170 4197-0004 226 µM 0.60448049607055 0.267580637034362 no 902 0.272762116244029 1362 218692
SGTC_396 dithiazanine 1.25 µM 0.604215119765205 0.2676709486121 no 903 0.272850314939061 1293 10578 An antihelmenthic.
SGTC_2211 7117706 200 µM 0.603987445873257 0.267748441729092 no 904 0.272925994384128 1310 822771
SGTC_514 4466-0038 2.65 nM 0.603730269084801 0.267835990309834 no 905 0.27301149319316 1291 5722064
SGTC_2733 amorolfine 100 µM 0.602953008325898 0.268100674424735 no 906 0.273269975378329 1376 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_452 diindolylmethane 8 µM 0.602013210743961 0.268420883675973 no 907 0.273582671858586 1342 3071 Inhibits expression of several cancer promoting factors.
SGTC_2314 7727897 200 µM 0.600604673220793 0.268901162546212 no 908 0.274051662315095 1322 900724
SGTC_3064 1327-0027 10 µM 0.598727598436348 0.269541871785034 no 909 0.274677275030325 1255 16000455 YPR107C YTH1
SGTC_2102 5377816 72.7585 µM 0.598066262378681 0.269767790303366 no 910 0.274897860255857 1378 1379702
SGTC_3352 9151559 45.5865 µM 0.595094065533341 0.270784289527344 no 911 0.275890297639099 1300 17159339
SGTC_3252 9135871 49.47 µM 0.594399817707656 0.271021999303208 no 912 0.276122365187416 1367 17682838
SGTC_646 4092-0839 27.3 µM 0.594183833540208 0.271095973294563 no 913 0.276194582166432 1416 877796
SGTC_1360 1598-0022 39.8 µM 0.593511168651143 0.271326423690405 no 914 0.276419555369342 1424 761525
SGTC_687 k029-0044 34.9 µM 0.592943405226719 0.271521011509751 no 915 0.276609514125695 1387 5829338
SGTC_2739 tacrine 100.86 µM 0.589781405682145 0.272605983744605 no 916 0.277668605178969 1357 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2704 st078022 71.1 µM 0.588798417736689 0.272943712906572 no 917 0.277998253699501 1421 54697681
SGTC_1333 1482-0047 286 µM 0.587123808875327 0.273519542442816 no 918 0.278560279162305 1325 3811116
SGTC_2746 daunorubicin 9.88 µM 0.586543098487732 0.273719365323581 no 919 0.278755303988968 1303 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2126 5251174 33.877 µM 0.585194390882914 0.274183735050687 no 920 0.279208508012495 1443 790722
SGTC_2249 haloperidol 116.36 µM 0.583657777292152 0.274713275936717 no 921 0.279725289838384 1356 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_697 0508-1955 564 µM 0.583118383811306 0.274899278808996 no 922 0.279906804414059 1371 6243113
SGTC_328 k915-0120 63.5 µM 0.582179972120873 0.275223025795821 no 923 0.280222731095328 1404 6624543
SGTC_2849 9019321 12.99 µM 0.581333388558183 0.275515253531702 no 924 0.280507890957155 1365 16489627
SGTC_1958 st076513 41.9 µM 0.581167740148001 0.275572450683698 no 925 0.280563703737857 1312 732122 YGL099W LSG1
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.580576936443944 0.275776498305742 no 926 0.280762810055319 1323 1241132 A phosphatase inhibitor.
SGTC_1559 coumarin 343 70.1 µM 0.579669295308655 0.276090117592105 no 927 0.281068826580471 1423 108770 A hepatotoxic, DNA x-linker.
SGTC_983 1491-0821 12.2 µM 0.57900173704249 0.276320892199849 no 928 0.281294000552153 1390 46495113
SGTC_1492 4158-0558 28.5 µM 0.578899360011348 0.276356292263345 no 929 0.28132854103251 1433 3967268
SGTC_3019 9081971 49.47 µM 0.577861309651034 0.276715356255234 no 930 0.28167887928038 1442 16451803
SGTC_1503 4585-0012 61.3 µM 0.575189584330931 0.277640562077001 no 931 0.282581543110298 1419 2922052
SGTC_1136 pergolide 1.05886 µM 0.574568834731913 0.277855740867995 no 932 0.282791467240712 1382 47811 A dopamine receptor agonist.
SGTC_1469 k284-2957 126 µM 0.573964558281573 0.278065287520362 no 933 0.282995892438933 1410 23884841
SGTC_2110 5483698 200 µM 0.573153769277707 0.27834656817693 no 934 0.283270291711168 1383 2848765 YHR062C RPP1
SGTC_3179 9107801 49.47 µM 0.57167422744686 0.278860211160129 no 935 0.283771348906941 1358 4818259
SGTC_2594 a-mangostin 100 µM 0.571474909419327 0.27892944234876 no 936 0.283838881774045 1442 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2139 5578692 56.4705 µM 0.571010908351024 0.279090641013464 no 937 0.283996124255991 1365 650991 YMR113W FOL3
SGTC_586 0957-0265 8.15 µM 0.569578837735819 0.279588442284692 no 938 0.284481692550687 1322 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1150 3909-7983 10.9 µM 0.568064891888483 0.280115172419775 no 939 0.284995452900211 1349 23965914
SGTC_3163 9099914 49.47 µM 0.566786343118551 0.280560377727514 no 940 0.285429675126473 1418 16268368
SGTC_150 3970-0969 77.2 µM 0.566733758107537 0.280578695758592 no 941 0.285447540852078 1434 6615640
SGTC_2965 9082772 38.63 µM 0.56562793371083 0.280964044571716 no 942 0.285823367296632 1438 16459634
SGTC_3076 9116187 49.47 µM 0.564573512025456 0.281331719029426 no 943 0.286181942981038 1433 27241210
SGTC_1712 st032288 53.4 µM 0.56351885106172 0.281699709091685 no 944 0.286540813632278 1360 2883011
SGTC_1387 3342-1166 1.8 µM 0.563455409936455 0.28172185223164 no 945 0.286562407619535 1389 3418228
SGTC_2472 5377652 49.4 µM 0.562586698233412 0.282025146947016 no 946 0.286858175927579 1366 1610903
SGTC_2699 st077704 54.6 µM 0.561852539856178 0.28228158738388 no 947 0.287108245902793 1418 645852
SGTC_1090 efavirenz 20.7 µM 0.561593489513493 0.282372100058823 no 948 0.287196508595165 1416 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3315 9136395 68.55 µM 0.560985282701133 0.282584663510054 no 949 0.287403785073205 1419 16876844
SGTC_322 k048-0136 19.3 µM 0.560741928472134 0.282669735421021 no 950 0.287486739848842 1383 6823282
SGTC_191 3914-0123 66.505 µM 0.557935541366975 0.283651682157946 no 951 0.288444200417341 1302 3144412
SGTC_3105 9121040 49.47 µM 0.557080904723279 0.283951041284669 no 952 0.28873607673326 1292 41448907
SGTC_684 1140-0066 328 µM 0.557037277961749 0.283966326768627 no 953 0.288750979916192 1372 6813534
SGTC_1963 st076565 50.3 µM 0.556995403396918 0.283980998706735 no 954 0.288765284878089 1417 4914280
SGTC_2201 6605497 169.863 µM 0.556901637343881 0.284013853610773 no 955 0.288797317938969 1431 670741
SGTC_353 1988-1175 58.3 µM 0.553839811503043 0.285087691824191 no 956 0.289844239795932 1338 2788357
SGTC_419 nsc-638432 893 µM 0.551888616199658 0.285773019848056 no 957 0.290512334126527 1414 368090
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.549744277190465 0.286527089252129 no 958 0.291247391521092 1462 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2162 5663267 200 µM 0.549730556904399 0.286531917109069 no 959 0.291252097488315 1440 6456493
SGTC_2445 5742597 35.57 µM 0.54960341013139 0.286576659005516 no 960 0.291295709677602 1370 1774255
SGTC_2020 4017018 200 µM 0.5489629382142 0.28680208614465 no 961 0.291515442140234 1395 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_836 0330-0104 1.35 µM 0.548643945268673 0.286914393556821 no 962 0.291624910750421 1419 46494820
SGTC_1842 st055362 61.2 µM 0.546553042894676 0.287651050121048 no 963 0.292342918450669 1467 676032
SGTC_3356 9151811 4.48 µM 0.546354416826587 0.2877210755574 no 964 0.292411168600436 1387 1859254 YPR165W RHO1
SGTC_3247 9135149 49.47 µM 0.545971193097769 0.28785620348532 no 965 0.292542869511273 1391 8934436 YOR116C RPO31
SGTC_1611 st001856 99.4 µM 0.545314978337825 0.288087659937943 no 966 0.292768452109026 1361 647478
SGTC_1852 st056254 31.4 µM 0.544766294373664 0.288281256113275 no 967 0.292957131537404 1436 442583
SGTC_186 3455-3465 67.277 µM 0.544144202178653 0.288500827638685 no 968 0.293171122546808 1377 755278
SGTC_1891 st059073 26.2 µM 0.543220546866871 0.288826983145248 no 969 0.293488980674031 1517 688754
SGTC_1372 2752-0194 270 µM 0.542501789279431 0.289080906443806 no 970 0.293736437586596 1370 823334
SGTC_1127 asiatic acid 681.4 nM 0.542236885218415 0.289174518449531 no 971 0.293827664225007 1390 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3195 9113082 49.47 µM 0.537886409555663 0.290713928082862 no 972 0.295327735769934 1415 17018038
SGTC_956 1185-0240 191 µM 0.537263197642084 0.290934764189388 no 973 0.295542911432928 1441 1416193
SGTC_197 4544-0043 41.561 µM 0.536815415390086 0.291093484906851 no 974 0.295697561189038 1424 896523
SGTC_806 3966-4455 5.86 µM 0.535483227654911 0.291565930617723 no 975 0.296157876240768 1364 714982
SGTC_1844 rapamycin 4 nM 0.533838337587216 0.292149765555064 no 976 0.296726693455406 1430 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2675 theaflavin digallate 100 µM 0.533788886356601 0.292167326124813 no 977 0.296743801861452 1441 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_519 k048-0011 62.8 µM 0.532250789027538 0.29271376314725 no 978 0.297276155367372 1465 6836379
SGTC_122 0236-0016 402.397 µM 0.530021597575243 0.293506565263772 no 979 0.298048478255533 1461 6808838
SGTC_329 k048-0121 21.3 µM 0.529862132063694 0.293563316564707 no 980 0.298103761504259 1435 6832902
SGTC_221 trifluoperazine 10.304 µM 0.529672650463535 0.293630756730709 no 981 0.298169456755558 1411 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1165 k072-0275 30.3 µM 0.529225648285615 0.293789881861494 no 982 0.298324463205227 1437 6153523 YGL055W OLE1
SGTC_3004 9076122 71.4286 µM 0.528674220183609 0.293986235784649 no 983 0.298515731839741 1494 44782551
SGTC_1810 st050138 53 µM 0.527538309188301 0.294390904976205 no 984 0.298909910225133 1448 3444541
SGTC_1962 st076595 64.5 µM 0.526807263137043 0.294651476650147 no 985 0.299163719305646 1447 279619
SGTC_1667 st014849 34.6 µM 0.526259097480566 0.29484693279815 no 986 0.299354098986198 1468 5348460
SGTC_3181 9108277 49.47 µM 0.525214588172883 0.295219532570649 no 987 0.299717012412957 1385 17097298
SGTC_3241 9133421 49.47 µM 0.524722606014554 0.295395108641572 no 988 0.299888019995486 1458 17018221
SGTC_3232 9132874 49.47 µM 0.524550489226411 0.295456544139486 no 989 0.299947856322973 1415 3784940
SGTC_3007 9078383 71.4286 µM 0.524263691994049 0.29555892681565 no 990 0.300047573258219 1450 6496995
SGTC_376 3970-0862 59.1 µM 0.523924806850908 0.295679925181838 no 991 0.300165420038835 1521 3135186
SGTC_1109 tnp00067 928.257 nM 0.522988787015541 0.296014247698878 no 992 0.300491028167514 1433 676295
SGTC_808 0711-0032 135 µM 0.521323555600208 0.296609454626734 no 993 0.301070697155401 1510 4252555
SGTC_702 1488-0190 94 µM 0.521186865027503 0.296658336543378 no 994 0.30111830167694 1523 949357
SGTC_1107 amlodipine 47 µM 0.520669572239011 0.296843359012725 no 995 0.301298487269672 1382 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3316 9136639 10.545 µM 0.520625391897315 0.296859163644575 no 996 0.301313878601745 1510 4903665
SGTC_424 splitomicin 100 mM 0.520381448128123 0.296946436571988 no 997 0.301398868916375 1409 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1572 epiandrosterone 68.9 µM 0.52035001370787 0.296957683352919 no 998 0.301409821492583 1445 441302 A steroid.
SGTC_1369 1866-0067 208 µM 0.51943211726143 0.297286179315631 no 999 0.301729719641984 1543 3531355
SGTC_2457 5731572 11.68 µM 0.519355887944639 0.297313467661609 no 1000 0.301756293355809 1572 2865357
SGTC_2407 paclitaxel 400 µM 0.51907007410138 0.297415792646654 no 1001 0.30185593808038 1590 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2121 5257820 149.641 µM 0.51848119661984 0.297626668956032 no 1002 0.302061288016097 1487 791256
SGTC_382 3229-0966 23.2 µM 0.518065987898576 0.297775395700038 no 1003 0.302206114887674 1540 5722370
SGTC_2368 9071271 200 µM 0.517087974609509 0.2981258515566 no 1004 0.302547373891095 1414 27209959
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.514053023351328 0.29921457349686 no 1005 0.303607459936551 1429 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1073 triclabendazole 3.09 µM 0.511468625352977 0.300143089112776 no 1006 0.304511476160743 1494 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_825 1988-2224 89.6 µM 0.510093267955275 0.300637754494957 no 1007 0.304993060667314 1482 1180859
SGTC_1527 coumarin 137 µM 0.508792264350133 0.301106015975236 no 1008 0.305448921101892 1517 323 A hepatotoxic, DNA x-linker.
SGTC_2114 5491910 81.25 µM 0.506979632740451 0.301758971639774 no 1009 0.306084554699649 1549 2849228
SGTC_2671 danthron 100 µM 0.506739040578896 0.301845686840764 no 1010 0.306168966862067 1446 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1114 scopoletin 1.73284 µM 0.506246220203182 0.302023346109494 no 1011 0.306341905843731 1544 5280460 A coumarin with genotoxic properties.
SGTC_1065 prochlorperazine maleate 2.48 µM 0.502086090761722 0.303524919342134 no 1012 0.307803481926676 1493 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.501989958574803 0.303559657048933 no 1013 0.307837292195538 1503 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3325 9138760 55.175 µM 0.501463171331197 0.303750044998949 no 1014 0.308022595402473 1441 43844959
SGTC_2897 9048598 12.99 µM 0.501407123281268 0.303770304649056 no 1015 0.30804231380268 1449 6467404
SGTC_2219 9098279 200 µM 0.499312424556841 0.304527905854982 no 1016 0.308779651795348 1515 902349
SGTC_1307 1187-1599 12.2 µM 0.498973028654084 0.304650736137486 no 1017 0.308899192508973 1458 1538471
SGTC_380 3970-0968 6 µM 0.497995329133239 0.305004697052168 no 1018 0.309243667186582 1437 2891601
SGTC_1708 st033234 31.827 µM 0.496460645683371 0.305560673369795 no 1019 0.309784723288764 1545 674664
SGTC_673 1082-0474 110 µM 0.496376282578852 0.305591248971813 no 1020 0.309814477657712 1463 3098046
SGTC_2264 7948757 110.76 µM 0.493485361735086 0.306639819443591 no 1021 0.310834840229776 1455 2971411
SGTC_2978 9011784 42.97 µM 0.491010943988019 0.307538578632325 no 1022 0.311709353566577 1676 2994934
SGTC_2540 epiandrosterone 100 µM 0.490822225364945 0.307607172634817 no 1023 0.311776094539969 1519 441302 A steroid.
SGTC_484 loperamide 105 µM 0.490615317647655 0.307682385601069 no 1024 0.311849275252246 1492 3955 An opioid-receptor agonist.
SGTC_504 lovastatin 124 µM 0.489140211255457 0.308218835211412 no 1025 0.312371217362748 1451 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1270 0831-1170 17.3 µM 0.486195295195824 0.309291033389495 no 1026 0.313414353389891 1461 6764716
SGTC_633 0437-0093 97.7 µM 0.482819909886254 0.310521958676746 no 1027 0.314611806363026 1506 2831118
SGTC_2443 5493264 126.67 µM 0.482620968840144 0.310594574329458 no 1028 0.314682443814951 1609 5340055
SGTC_2093 5331342 194.4 µM 0.48083517518799 0.311246738706008 no 1029 0.315316824114094 1562 33839
SGTC_603 3794-0023 45.9 µM 0.479504675592128 0.311733017202016 no 1030 0.3157898213847 1594 3802260
SGTC_460 trequinsin 123 µM 0.478691339603291 0.312030441651086 no 1031 0.316079113885479 1523 5537 A vasodilator.
SGTC_2785 7756463 72.73 µM 0.478560924602528 0.312078143817867 no 1032 0.316125511203602 1454 2201551
SGTC_1421 4029-0249 71.4 µM 0.475318669854066 0.31326508145654 no 1033 0.317279926918145 1620 2894095
SGTC_3298 9116858 71.43 µM 0.473878263727603 0.313793013326089 no 1034 0.317793360117774 1584 2506942
SGTC_1418 3966-3099 2.4 µM 0.473818072244914 0.313815082777476 no 1035 0.317814823026768 1577 740335
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.473775222593861 0.313830794181839 no 1036 0.317830102607384 1567 279621
SGTC_867 0518-0118 155 µM 0.473378520960032 0.313976266230181 no 1037 0.317971575535923 1537 6848158
SGTC_2146 5545642 200 µM 0.47320148391878 0.314041195741523 no 1038 0.31803471959297 1516 825326
SGTC_1830 st055982 50.3 µM 0.472871344152851 0.314162292071225 no 1039 0.318152485149219 1577 455313 An antimicrobial agent.
SGTC_2430 5571206 200 µM 0.472591435419374 0.314264979171119 no 1040 0.318252346984054 1595 1731771
SGTC_268 camptothecin 39.6153 µM 0.472299039634572 0.314372262614296 no 1041 0.318356677878399 1534 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2318 6029776 164 µM 0.471317330157463 0.31473257800009 no 1042 0.318707070874419 1601 818325
SGTC_2608 thymoquinone 42.66 µM 0.470808440197203 0.314919424603965 no 1043 0.318888768361014 1465 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_418 lividomycin a 100 µM 0.470323857480725 0.315097390479589 no 1044 0.319061827495021 1569 72394 An antibiotic.
SGTC_480 am 92016 50 µM 0.468794155131775 0.315659464229832 no 1045 0.31960838909192 1478 2129 K+ channel blocker.
SGTC_207 4185-0010 4.486 µM 0.468512677732263 0.315762936785913 no 1046 0.319709003514227 1571 3761753
SGTC_2125 5246583 200 µM 0.466114017165453 0.316645282086821 no 1047 0.320566945224507 1655 835267
SGTC_1490 4089-0339 670 nM 0.46458195344451 0.317209397360279 no 1048 0.32111542914244 1592 742542
SGTC_638 3970-0837 4.09 µM 0.463394311000223 0.31764698710465 no 1049 0.321540877856204 1499 4118451 YLR208W SEC13
SGTC_1607 st000305 50.6 µM 0.462861740503254 0.317843296808814 no 1050 0.321731736477418 1571 5457690
SGTC_2419 paclitaxel 166.5 µM 0.462648130457324 0.317922049555861 no 1051 0.321808301667633 1543 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2558 carylophyllene oxide 100 µM 0.461719478664115 0.318264516219966 no 1052 0.322141250344159 1592 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2180 6301957 200 µM 0.460948866547122 0.318548819271564 no 1053 0.322417645618364 1552 845462
SGTC_1489 4065-0444 182 µM 0.460206437758173 0.318822825689508 no 1054 0.322684025261424 1627 2877968
SGTC_1448 4255-0083 152 µM 0.458747529981474 0.319361549797831 no 1055 0.323207738973527 1681 5399660
SGTC_993 3909-8757 62.7 µM 0.457576491821891 0.319794249760868 no 1056 0.323628367951555 1559 4288324 YLR208W SEC13
SGTC_2131 toluylene red 5.2905 µM 0.455826859280723 0.3204411980456 no 1057 0.324257244030206 1481 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2955 9076254 12.21 µM 0.454028153861161 0.321106860897655 no 1058 0.32490428157091 1619 16459619
SGTC_608 k048-0125 159 µM 0.453846498443046 0.321174119744941 no 1059 0.324969656805001 1595 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2780 5215298 71.43 µM 0.453234507452563 0.321400755700621 no 1060 0.325189943426071 1661 2834131
SGTC_2330 7979373 200 µM 0.451937558129624 0.321881269035889 no 1061 0.325656983218917 1445 1863007
SGTC_1077 5-fluorocytosine 377 nM 0.449432951646033 0.322810056317639 no 1062 0.32655968258298 1555 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_580 1123-0028 41 µM 0.44905248250672 0.322951243242979 no 1063 0.326696898678261 1573 1677248 YPR107C YTH1
SGTC_3303 9125618 40.5795 µM 0.448164900149494 0.323280712162733 no 1064 0.327017096140675 1641 22695467
SGTC_828 2074-0507 139 µM 0.448094205817321 0.323306959731894 no 1065 0.327042604770538 1636 X828
SGTC_1290 0986-0249 10.2 µM 0.44685751117429 0.323766264993441 no 1066 0.327488971814877 1541 53329
SGTC_3251 9135047 49.47 µM 0.445920918447793 0.324114291904182 no 1067 0.327827185636167 1652 17682963
SGTC_3057 9095946 49.47 µM 0.445855279804272 0.324138688226028 no 1068 0.327850893764779 1583 24540043
SGTC_1596 piperlongumine 63 µM 0.445237976148426 0.324368162240587 no 1069 0.328073892613089 1661 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_704 1310-0270 142 µM 0.444068403611535 0.324803117393063 no 1070 0.328496564754616 1522 5718033
SGTC_3207 9114163 49.47 µM 0.442133542553726 0.325523202027511 no 1071 0.329196286607739 1740 849233
SGTC_659 k018-0002 107 µM 0.440715418103739 0.326051390224423 no 1072 0.329709516604314 1670 6797879 YHR007C ERG11
SGTC_1202 1988-0068 29.6 µM 0.440672571876064 0.32606735397565 no 1073 0.329725027976955 1515 2850480
SGTC_2468 5987765 72.9 µM 0.440260528198778 0.326220890475963 no 1074 0.329874212720399 1607 26772094
SGTC_855 0428-0020 25 µM 0.439919939774533 0.326347823423397 no 1075 0.329997546771558 1558 6812414
SGTC_2325 6158266 200 µM 0.437475555544715 0.327259403611534 no 1076 0.330883249993278 1555 3623240
SGTC_3256 9138902 49.47 µM 0.437324260719347 0.327315859685588 no 1077 0.33093810165847 1623 17228773
SGTC_2010 4012422 159 µM 0.436965556369887 0.327449726969046 no 1078 0.331068163772557 1620 952393
SGTC_2528 xanthyletin 44.79 µM 0.436480291789407 0.327630861427484 no 1079 0.331244147629972 1587 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_834 0312-0008 75.7 µM 0.436471897093948 0.327633995268243 no 1080 0.331247192340372 1591 6385573 YIL048W NEO1
SGTC_2388 9080168 200 µM 0.436207108028574 0.327732850441291 no 1081 0.33134323561939 1500 15943073
SGTC_2414 st077232 92.9 µM 0.436174637211099 0.327744973783275 no 1082 0.331355014074097 1492 729801
SGTC_2581 avocatin a 64 µM 0.435319928753582 0.328064153980193 no 1083 0.331665110723219 1573 6710728 A skin care supplement.
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.435094374831634 0.328148405229778 no 1084 0.331746963160818 1622 140250 A respiratory chain inhibitor.
SGTC_936 3005-4620 401 µM 0.434074576745605 0.328529439910255 no 1085 0.332117143218688 1677 777207
SGTC_774 k060-0086 136 µM 0.434051525312474 0.328538054850319 no 1086 0.332125512634135 1733 5911235
SGTC_763 3453-1109 128 µM 0.433820028326997 0.328624576548454 no 1087 0.332209568209161 1639 1560353
SGTC_2386 9075165 157.42 µM 0.432501607816815 0.329117509565428 no 1088 0.332688441951488 1573 16452277
SGTC_410 α-linolenic acid 100 µM 0.431297938367861 0.329567798910228 no 1089 0.333125874603113 1647 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2934 9036370 36.88 µM 0.431162445566322 0.329618501876872 no 1090 0.333175129078815 1698 6462800
SGTC_2651 TUB2.036 5 µM 0.428881862734792 0.33047239161091 no 1091 0.334004600022887 1655 15992207 YFL037W TUB2
SGTC_314 1671-0008 2.74 µM 0.428037045701191 0.330788930207742 no 1092 0.334312074710204 1553 3913060
SGTC_1262 0737-0114 49.6 µM 0.425735535676582 0.331651880394624 no 1093 0.335150282519885 1644 765919
SGTC_1683 st010134 710 nM 0.425308336512767 0.3318121570658 no 1094 0.335305958583312 1543 3818134
SGTC_1642 st009582 77.7 µM 0.424626330562747 0.33206809600139 no 1095 0.335554547654282 1687 6739311
SGTC_2929 9013348 24.6 µM 0.424409223597385 0.332149586997385 no 1096 0.335633697588378 1588 2995952
SGTC_334 1502-1024 68.5 µM 0.423426571669854 0.33251852415635 no 1097 0.335992030762375 1600 3296216
SGTC_1177 0983-0204 23.6 µM 0.423281264293895 0.332573093666297 no 1098 0.336045031112999 1720 766818
SGTC_1015 4130-4525 82 µM 0.423090825483411 0.332644617448998 no 1099 0.336114497930284 1535 1363237
SGTC_2933 9026794 32.47 µM 0.421883973747745 0.333098020600309 no 1100 0.336554854151048 1643 17586027
SGTC_785 1270-0111 65.3 µM 0.421099901450375 0.333392720228213 no 1101 0.33684106676817 1564 6741994
SGTC_2531 methyl deoxycholate 70.07 µM 0.421032431584298 0.333418084107588 no 1102 0.336865699944805 1553 16667744 Haematoxylin.
SGTC_688 0527-0193 473 µM 0.419463996857633 0.33400791864208 no 1103 0.337438530818186 1635 4007154
SGTC_3172 9105863 49.47 µM 0.417054077711964 0.334915005762843 no 1104 0.338319426695846 1642 2348785
SGTC_101 0490-5701 117.494 µM 0.415525983923666 0.33549067594837 no 1105 0.338878448813647 1685 4661669
SGTC_79 0052-0007 94.094 µM 0.415084230804676 0.335657167178736 no 1106 0.339040121440007 1698 2801472
SGTC_215 1287-0124 461.5 µM 0.414358466281328 0.335930768801407 no 1107 0.339305800799 1700 5560863
SGTC_1480 1070-0044 41.2 µM 0.412201577172084 0.33674439433075 no 1108 0.340095840622145 1663 3124987
SGTC_3191 9110352 49.47 µM 0.411145446314883 0.337143069025904 no 1109 0.340482943798264 1637 17122424
SGTC_2508 celastrol 40.54 µM 0.411114782016841 0.337154647106955 no 1110 0.340494185683196 1550 122724 Celastrol is a natural product and antioxidant.
SGTC_2649 anisomycin 9.56 µM 0.410738463504549 0.337296748235076 no 1111 0.340632159924319 1608 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.409434389828976 0.337789357230023 no 1112 0.341110453256414 1743 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_968 1309-0633 340 µM 0.4090579081832 0.337931623525245 no 1113 0.341248582466642 1697 3761976
SGTC_1622 st003707 19.4 µM 0.409040824581092 0.337938079690129 no 1114 0.341254850858483 1653 10140899
SGTC_1358 1509-0022 2.48 µM 0.408525319689922 0.338132919601994 no 1115 0.34144402281971 1621 3258434
SGTC_2001 4023502 57.655 µM 0.405967947135753 0.339100142834834 no 1116 0.342383075888282 1672 108941 YCR052W RSC6
SGTC_141 0443-0274 32.331 µM 0.403519707574043 0.340027085610738 no 1117 0.343282969884216 1701 1627241
SGTC_2128 5255449 168.493 µM 0.403377853910328 0.340080823400145 no 1118 0.343335138025888 1581 736008
SGTC_3108 9121785 49.47 µM 0.402021991519658 0.340594622484038 no 1119 0.343833920845756 1740 17140271
SGTC_362 0310-0100 9.03 µM 0.401904661084503 0.340639098348768 no 1120 0.343877096138081 1615 790235
SGTC_532 1548-0774 215 µM 0.400962831265462 0.340996193331834 no 1121 0.344223744710989 1741 5932993
SGTC_721 1187-1332 279 µM 0.400711936901325 0.341091344032609 no 1122 0.344316110637588 1586 25730
SGTC_2438 5259590 200 µM 0.399911330027095 0.34139503859619 no 1123 0.344610913472097 1748 1201127
SGTC_955 1216-0110 33 µM 0.398972167277615 0.341751422557396 no 1124 0.344956856245623 1564 3619719
SGTC_15 0266-0086 27.098 µM 0.397922814516454 0.342149787194552 no 1125 0.34534354111173 1695 1712902 YIL048W NEO1
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.396875620265097 0.342547507614814 no 1126 0.345729591570982 1736 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2972 9093619 59.92 µM 0.396413676187433 0.342723007766003 no 1127 0.345899939299627 1564 25236256
SGTC_1112 tnp00069 1.16933 µM 0.396142521143127 0.342826039841731 no 1128 0.345999945688729 1720 145826
SGTC_2199 6590217 200 µM 0.394788868761852 0.343340568325215 no 1129 0.346499355253555 1679 703109
SGTC_1066 ketoconazole 628 nM 0.394568669046399 0.343424294581073 no 1130 0.346580619872609 1711 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_3192 9110362 49.47 µM 0.393848393977602 0.343698217504558 no 1131 0.346846486410184 1668 16649480
SGTC_2992 9074591 71.4286 µM 0.393294429149766 0.34390894796153 no 1132 0.347051016156785 1636 17741321
SGTC_3049 9092223 49.47 µM 0.392781120360754 0.344104255989124 no 1133 0.347240575039561 1642 8623917
SGTC_2764 methyldopa 94.69 µM 0.391569312777675 0.344565499615595 no 1134 0.347688232843012 1742 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_947 3447-0010 211 µM 0.391125803008426 0.344734368117963 no 1135 0.347852124377418 1617 748350
SGTC_301 4119-0100 24.5 µM 0.390891997697944 0.34482340308435 no 1136 0.347938534622606 1645 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2081 5214970 32.255 µM 0.390772491913259 0.344868915179849 no 1137 0.347982704865387 1735 2063512
SGTC_2287 7945887 168.79 µM 0.390407872890171 0.345007789071379 no 1138 0.348117483562529 1750 1245853
SGTC_3039 9090270 49.47 µM 0.390327824299635 0.34503828029088 no 1139 0.348147075494924 1754 17173750
SGTC_525 k781-2675 26.7 µM 0.387395395209426 0.346155960731852 no 1140 0.349231756140181 1667 3651118 YDL195W SEC31
SGTC_1786 berberine 21.6 µM 0.386904612158782 0.346343151493701 no 1141 0.349413413281894 1577 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2935 9038016 29.96 µM 0.385972055440932 0.346698943630196 no 1142 0.349758682382987 1704 6463195
SGTC_1186 1319-0216 26 µM 0.384191076213053 0.34737880432774 no 1143 0.350418415950615 1813 4565136
SGTC_3142 9086498 49.47 µM 0.383030326520973 0.347822166806678 no 1144 0.350848639172837 1759 25236367
SGTC_804 1595-0054 20.9 µM 0.382843769386717 0.347893444008658 no 1145 0.350917803042826 1652 761523 Stimulates phospholipase C.
SGTC_3091 9116372 49.47 µM 0.381684327812295 0.348336548042109 no 1146 0.351347763087226 1668 17169793
SGTC_3061 glucosamine 200 µM 0.381438513649785 0.348430517518099 no 1147 0.35143894373866 1762 91431 and experimental redox chemotherapeutic
SGTC_156 3474-0145 5.642 µM 0.380907951780637 0.348633371631512 no 1148 0.351635775924184 1800 2265471
SGTC_3347 9188721 44.724 µM 0.380859842162341 0.348651767921691 no 1149 0.351653625992169 1687 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2436 5633522 8.09 µM 0.380186641507599 0.348909225583234 no 1150 0.351903437313128 1786 5724242
SGTC_1933 st074711 15.9 µM 0.380008355986215 0.348977420438991 no 1151 0.351969606224062 1611 17250958
SGTC_3125 9127534 49.47 µM 0.3790537439655 0.349342645922229 no 1152 0.352323977272011 1639 1639235
SGTC_405 ebelactone b 50 µM 0.378516671892258 0.349548185952987 no 1153 0.352523405545387 1634 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3092 9117248 49.47 µM 0.374088286225899 0.351244626800517 no 1154 0.354169316653103 1747 17141857
SGTC_3162 9099653 49.47 µM 0.373681739718114 0.351400517264726 no 1155 0.354320556171121 1716 25237511
SGTC_3106 9121286 49.47 µM 0.373146334742077 0.351605856712834 no 1156 0.3545197674292 1740 15943471
SGTC_1188 1403-0014 4.57 µM 0.370680240366041 0.352552215811497 no 1157 0.355437854703005 1668 9614867
SGTC_1751 st044839 27.194 µM 0.370087533608523 0.352779802281414 no 1158 0.355658635228833 1705 5291326
SGTC_2677 mitomycin C 100 µM 0.369102848207135 0.353158016460526 no 1159 0.356025533026956 1681 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3 0833-0587 95.581 µM 0.367629333792313 0.353724259068733 no 1160 0.356574819538838 1689 5382644
SGTC_389 tpck 16.7 µM 0.367012597288634 0.353961354969259 no 1161 0.356804810723222 1683 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2582 agaric acid 100 µM 0.365883907921414 0.354395410762273 no 1162 0.357225852325458 1614 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2814 7977482 42.97 µM 0.364763731804066 0.354826379715939 no 1163 0.357643890131859 1793 6456762
SGTC_2124 5246320 200 µM 0.364349190440815 0.354985914689603 no 1164 0.357798635892178 1710 579342
SGTC_223 busulfan 5 mM 0.364034259133363 0.355107132037179 no 1165 0.357916213452124 1735 2478 A DNA alkylator.
SGTC_252 miconazole 1.30953 nM 0.363441251692617 0.355335420939068 no 1166 0.358137645513831 1737 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2259 7964009 200 µM 0.362792281079522 0.355585313374574 no 1167 0.358380029210493 1734 313134
SGTC_2214 7179297 48.276 µM 0.362529954581903 0.355686342366081 no 1168 0.358478021600548 1737 769744
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.36249665040664 0.35569916942536 no 1169 0.358490463083542 1731 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1132 3456-3614 2.5 µM 0.361984193247859 0.355896562218563 no 1170 0.35868192128403 1875 3125502
SGTC_963 1269-2853 151 µM 0.36120799219323 0.356195619795415 no 1171 0.358971983998235 1622 3668223
SGTC_1452 4194-0072 190 µM 0.360827045645639 0.356342424651265 no 1172 0.35911437171083 1826 1343545
SGTC_1438 4092-1045 4 µM 0.360658538094348 0.356407368971927 no 1173 0.359177361607827 1662 1351342
SGTC_856 0433-0016 11.3 µM 0.360089244236852 0.356626810718574 no 1174 0.359390197951464 1685 3911780
SGTC_2836 9010338 19.48 µM 0.359047038324517 0.357028665532267 no 1175 0.35977995033313 1552 2994051
SGTC_1030 k029-0042 36.7 µM 0.358663863894378 0.357176450234026 no 1176 0.359923282267641 1701 6080581
SGTC_1257 0669-0121 16 µM 0.357864301515216 0.357484898587699 no 1177 0.360222433553752 1794 4307855
SGTC_478 N-arachidonylglycine 10 µM 0.355497808317002 0.358398369144641 no 1178 0.361108343275138 1766 5283389
SGTC_37 0566-0070 1.56 µM 0.355386169332916 0.358441482059636 no 1179 0.361150154392566 1801 1626686
SGTC_1755 st041960 45.185 µM 0.355109002431514 0.358548526600892 no 1180 0.361253966322623 1705 2257073
SGTC_169 k015-0017 16.025 µM 0.35466294303006 0.358720822394901 no 1181 0.361421057822026 1767 1840002
SGTC_1357 1503-1303 39.5 µM 0.354424887473777 0.358812785978942 no 1182 0.36151024299888 1691 292895
SGTC_3086 9117350 49.47 µM 0.354081492040607 0.358945457980398 no 1183 0.36163890598187 1661 2679265
SGTC_2203 7227154 166.4 µM 0.35389791643775 0.359016390024354 no 1184 0.361707694283603 1712 896304
SGTC_235 0330-0087 5 mM 0.353771768720931 0.359065135242003 no 1185 0.361754966157871 1694 46494818 YHR062C RPP1
SGTC_3093 9117344 49.47 µM 0.352631508419336 0.359505851576671 no 1186 0.362182356425147 1713 24824913
SGTC_2220 6782180 200 µM 0.351906423548821 0.359786197795801 no 1187 0.362454220834285 1780 833803
SGTC_1217 1183-1422 255 µM 0.3494707711658 0.360728468120167 no 1188 0.363367955219826 1787 2849664
SGTC_560 2332-1943 155 µM 0.347182384480069 0.361614537554566 no 1189 0.36422715194897 1701 21177716
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.346402918163442 0.36191651878167 no 1190 0.364519966169729 1692 442882
SGTC_2686 alizarin 95.37 µM 0.345449827024941 0.362285882668617 no 1191 0.364878111709046 1645 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2647 atorvastatin 60.16 µM 0.344963698691129 0.362474327759512 no 1192 0.365060830855285 1773 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1841 st054148 70 µM 0.343895856558596 0.36288838808878 no 1193 0.36546230401522 1668 675442
SGTC_1658 st012944 20 µM 0.343063855223379 0.363211111314271 no 1194 0.365775211096424 1785 24207260
SGTC_1003 4049-0218 100 µM 0.341250351678697 0.363914883678001 no 1195 0.366457560274007 1780 295161
SGTC_1145 3546-0597 10.2 µM 0.340646895512816 0.364149170885443 no 1196 0.366684710565655 1719 875334
SGTC_2077 5212015 200 µM 0.340032977981724 0.364387571746289 no 1197 0.366915846597948 1652 780900
SGTC_1523 st012844 44.7 µM 0.339441987035111 0.364617119162315 no 1198 0.367138396504138 1717 4274103
SGTC_2522 biochanin a 4.94 µM 0.339219197317279 0.364703665756549 no 1199 0.367222304188331 1782 5280373 A possible chelator.
SGTC_1465 k213-0056 144 µM 0.337968404092229 0.365189686355098 no 1200 0.367693499054579 1706 24048857 YMR208W ERG12
SGTC_2610 ononetin 44.17 µM 0.337813274634645 0.365249980107569 no 1201 0.367751952833311 1669 259632
SGTC_1637 st007924 17.4 µM 0.335906135566508 0.36599149453124 no 1202 0.368470825058441 1697 683336
SGTC_557 1315-0110 16.2 µM 0.334850826238314 0.366402024604679 no 1203 0.368868808845293 1671 6833801
SGTC_1525 8-methoxypsoralen 92.5 µM 0.334730407452224 0.366448878924337 no 1204 0.368914230757622 1895 4114 Related to psoralen; DNA damaging agent.
SGTC_1993 st073995 70.8 µM 0.332550570784028 0.367297385511989 no 1205 0.369736780150517 1753 3098394
SGTC_283 0987-0079 11.7 µM 0.332106081886386 0.367470483593308 no 1206 0.369904578923007 1825 411556
SGTC_12 0849-0099 9.267 µM 0.33209317200337 0.367475511514039 no 1207 0.36990945289656 1815 6071388
SGTC_1212 0520-0165 585 µM 0.330404079047709 0.368133546228266 no 1208 0.370547329903848 1899 5403258
SGTC_39 0986-0283 58.349 µM 0.330353931885351 0.368153088422861 no 1209 0.370566273164934 1870 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3037 9091026 49.47 µM 0.327475155855398 0.369275509062106 no 1210 0.371654265370576 1771 25236398 YIL048W NEO1
SGTC_635 k038-0028 24.7 µM 0.326213048462007 0.369767950797122 no 1211 0.372131584838703 1778 4035102
SGTC_2960 9079389 5.97 µM 0.325174655212645 0.370173265293881 no 1212 0.372524444726617 1867 16457355
SGTC_2072 5231554 129 µM 0.322715527472369 0.371133707407502 no 1213 0.3734553458055 1907 789545
SGTC_62 0180-0423 3.232 µM 0.322571495323716 0.371189985863723 no 1214 0.373509892034328 1799 30102 YGL099W LSG1
SGTC_2123 5259487 200 µM 0.32152112939635 0.371600484213847 no 1215 0.373907751322965 1840 2173474
SGTC_113 0099-0221 2.5 µM 0.321455528672888 0.371626126785548 no 1216 0.373932604132801 1843 89219
SGTC_3222 9128301 49.47 µM 0.32126629553863 0.37170009904229 no 1217 0.374004297971845 1718 4911358
SGTC_3079 9117512 49.47 µM 0.320891426163464 0.37184665149627 no 1218 0.37414633577996 1802 7185044
SGTC_1227 3909-8010 46.6 µM 0.320653483523043 0.371939683076225 no 1219 0.374236500986765 1761 15982272
SGTC_1561 5-methoxyflavone 52.9 µM 0.320335906920883 0.37206386184786 no 1220 0.37435685314464 1845 94525
SGTC_717 1532-0246 73.2 µM 0.318068021990836 0.372951036121367 no 1221 0.375216669868306 1737 9561992
SGTC_1056 3448-1962 115 µM 0.316650621358655 0.373505851986942 no 1222 0.375754360227736 1778 715507
SGTC_2304 7443016 91.4 µM 0.316584466529049 0.373531753515253 no 1223 0.375779461939206 1729 939854
SGTC_553 k007-0256 45.7 µM 0.316361852603521 0.373618917498177 no 1224 0.375863934168251 1779 6287000
SGTC_1587 estradiol valerate 56.1 µM 0.31396574712324 0.374557515675338 no 1225 0.376773527055463 1896 13791 A steroid.
SGTC_747 3448-8087 38.7 µM 0.313040937673856 0.374919979627724 no 1226 0.3771247801313 1718 5168703
SGTC_2904 7225135 42.03 µM 0.312385267358933 0.375177025862293 no 1227 0.377373872753073 1858 4446116
SGTC_346 4513-0042 7.16 µM 0.311847263533931 0.375387984036992 no 1228 0.377578301368175 1727 2827372
SGTC_128 0906-2981 13.371 µM 0.311571577325116 0.375496098568506 no 1229 0.377683068843827 1856 6740226
SGTC_2575 plumbagin 510 nM 0.308860961783091 0.376559627096384 no 1230 0.378713646905299 1687 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2364 9055074 200 µM 0.306303583521847 0.377563891842624 no 1231 0.379686755504643 1709 6470630
SGTC_975 1335-0046 28.5 µM 0.306210552852122 0.377600439997646 no 1232 0.379722169036089 1674 16486740
SGTC_1321 1326-2144 215 µM 0.304294823488731 0.37835329924884 no 1233 0.380451644274405 1883 3513030
SGTC_360 0957-0399 1.01 µM 0.304289022348153 0.378355579732388 no 1234 0.380453853891476 1864 6752301 YPR165W RHO1
SGTC_309 k408-0051 1.48 µM 0.302681028135245 0.378987860651541 no 1235 0.381066478668649 1781 3640463
SGTC_2817 7995342 71.43 µM 0.302122865366829 0.379207412184452 no 1236 0.381279201191285 1687 18879975
SGTC_565 1418-0001 44.5 µM 0.299045578850301 0.380418550830304 no 1237 0.382452634470112 1862 2862145
SGTC_1757 st041620 31.8375 µM 0.298560733768949 0.380609480325434 no 1238 0.382637614748259 1745 5289815
SGTC_2945 9067681 61.76 µM 0.29764136928124 0.380971601150523 no 1239 0.38298844832594 1821 16456930
SGTC_1981 st071826 47 µM 0.29739520684058 0.38106857773571 no 1240 0.383082401315352 1773 11838600
SGTC_394 menadione 8.33 µM 0.297385168623999 0.381072532486055 no 1241 0.383086232754433 1900 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_11 0438-0307 1.3 µM 0.296547743937826 0.381402495907809 no 1242 0.383405905638216 1905 4011476
SGTC_1291 0993-0025 5.79 µM 0.294634756881222 0.382156577243034 no 1243 0.384136454003435 1876 4353356
SGTC_1157 4092-0394 27.6 µM 0.293860252552943 0.382462006846446 no 1244 0.384432345817731 1873 3659885
SGTC_2397 5161689 200 µM 0.293366429967442 0.382656786412868 no 1245 0.384621041085586 1852 2259942
SGTC_234 nsc-17383 10.7 µM 0.291726522901975 0.383303831412666 no 1246 0.385247864268355 1890 408974
SGTC_1749 st037932 54.2 µM 0.291165388756316 0.383525308490875 no 1247 0.385462416041946 1771 594497
SGTC_103 0844-0104 51.839 µM 0.291098787675677 0.383551598160825 no 1248 0.385487883546886 1883 5375804
SGTC_831 k061-1017 217 µM 0.290665192219314 0.383722765863995 no 1249 0.385653697644147 1900 1240153
SGTC_2707 st078556 66.6 µM 0.289827350414394 0.384053579569129 no 1250 0.385974161436218 1935 17250899
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.2882651601449 0.38467062071686 no 1251 0.386571886948611 1764 688803
SGTC_74 000s-0487 160.283 µM 0.284687187956478 0.386084963718362 no 1252 0.387941903594605 1935 677548
SGTC_291 SEC14.278 35.5 µM 0.284316092538494 0.386231741736885 no 1253 0.388084077371557 1894 1068044
SGTC_1147 3809-1045 12.3 µM 0.284019372816134 0.386349113923588 no 1254 0.388197767185631 1788 325925
SGTC_681 1642-0006 26.6 µM 0.283935462017786 0.386382308056037 no 1255 0.388229919813654 1810 4446530
SGTC_1439 4092-1168 46 µM 0.283870782694634 0.386407895008862 no 1256 0.388254703919274 1838 2886240
SGTC_54 0159-0055 9 µM 0.283698211143462 0.386476166231237 no 1257 0.388320832866724 1927 3319099
SGTC_2630 antimycin a 100 µM 0.281705820977091 0.38726463190318 no 1258 0.389084545348276 1763 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2750 bromebric acid 70.15 µM 0.281212415574413 0.387459963471333 no 1259 0.389273741249707 1810 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_337 1315-0038 354 µM 0.281206377815789 0.387462353903156 no 1260 0.389276056586034 1810 1626437
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.280975763838888 0.387553660346683 no 1261 0.389364494483905 1787 15053
SGTC_1258 0671-0043 57.1 µM 0.278325559358616 0.388603394736722 no 1262 0.390381228708489 1759 4298767
SGTC_3021 9087658 49.47 µM 0.278322598343626 0.388604568038462 no 1263 0.390382365104013 1924 25237042
SGTC_280 3448-3607 3.04 µM 0.277592309334414 0.388893975957295 no 1264 0.390662668236066 1927 626179
SGTC_733 4069-0007 56.1 µM 0.277441380420047 0.388953795619938 no 1265 0.39072060560763 1855 5717425 YNL287W SEC21
SGTC_718 1130-0073 349 µM 0.276500217414103 0.389326878604239 no 1266 0.391081946340618 1873 6740020
SGTC_2614 arthonioic acid 13.39 µM 0.275791155343447 0.389608022723983 no 1267 0.391354238688327 1796 6710684
SGTC_2255 7941087 197.44 µM 0.274351919898469 0.390178859149652 no 1268 0.391907094109162 1941 935561
SGTC_324 1315-0088 19.6 µM 0.273956838695741 0.390335599629781 no 1269 0.392058895415297 1855 6787421
SGTC_1904 st060225 78 µM 0.271890577462754 0.391155636870246 no 1270 0.392853078255817 1785 66595
SGTC_1886 st057356 49.9 µM 0.270875708824252 0.391558585371378 no 1271 0.393243314177942 1764 24207747
SGTC_443 clozapine 122 µM 0.270501270664654 0.391707283578371 no 1272 0.393387319749983 1961 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_166 k072-0058 166.424 µM 0.269524334657633 0.392095322307155 no 1273 0.393763109241476 1966 5846229
SGTC_2411 st077133 39.94 µM 0.268039904295858 0.39268514301243 no 1274 0.394334301495825 1974 1403142 YNL221C POP1
SGTC_2661 dactinomycin 12.96 µM 0.26802877804023 0.392689564829965 no 1275 0.394338583614694 1849 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1550 gossypolone 36.6 µM 0.267533164334307 0.392886546607226 no 1276 0.394529341486622 1894 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2108 5365811 200 µM 0.267278680038449 0.392987702110158 no 1277 0.394627300349982 1903 780283
SGTC_1331 1472-0049 76.2 µM 0.267091752299637 0.393062009017947 no 1278 0.394699258853603 1794 24051409
SGTC_2962 9082311 13.18 µM 0.266714677803823 0.393211914302637 no 1279 0.394844425964498 1762 16459453
SGTC_573 3702-0553 84.7 µM 0.266612520581917 0.39325252944867 no 1280 0.394883757229378 1831 1222756
SGTC_281 1672-3440 14.9 µM 0.266560204232213 0.393273329565404 no 1281 0.394903899814939 1919 6833000
SGTC_888 0916-0002 6.97 µM 0.266427269694545 0.393326183512813 no 1282 0.394955082885244 1902 2802138 YIL048W NEO1
SGTC_3194 9111903 49.47 µM 0.266031365081428 0.393483604373721 no 1283 0.395107526645418 1880 17087251
SGTC_2565 isoliquiritigenin 100 µM 0.265623933247958 0.393645626906209 no 1284 0.395264425746377 1702 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1483 3453-0561 55.9 µM 0.265436961023999 0.393719985910773 no 1285 0.395336433105735 1908 4546991
SGTC_2763 lisinopril 49.32 µM 0.263756739575321 0.394388384937986 no 1286 0.395983685610969 1964 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2119 5528445 120.635 µM 0.262488261563714 0.394893196924329 no 1287 0.396472517049691 1943 791935
SGTC_563 tetrahydrosecaminediol 614 µM 0.261442188075614 0.395309632158557 no 1288 0.39687576330605 1966 334274 A psychoactive constituent of the cannabis plant.
SGTC_3340 9146634 11.102 µM 0.258971315200457 0.396293745040958 no 1289 0.397828686408846 1829 4907387
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.257814791775854 0.396754599122206 no 1290 0.39827492406255 1930 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2019 4016004 108 µM 0.256994855022534 0.397081416807443 no 1291 0.398591372409119 1796 45595336
SGTC_2148 5546263 113.568 µM 0.256084033968079 0.397444544707762 no 1292 0.398942975037608 1849 792097
SGTC_748 act1.228 77.9 µM 0.254960745843178 0.397892501786114 no 1293 0.399376708871828 1784 4421505 YNR035C ARC35
SGTC_1934 st074720 32.6 µM 0.254161634817218 0.398211261990733 no 1294 0.399685344268559 1756 17250992
SGTC_847 0342-0274 5.54 µM 0.253649114125137 0.398415738945446 no 1295 0.399883324774687 1961 18097
SGTC_390 dec-rvkr-cmk 16.7 µM 0.253624138020718 0.39842570420812 no 1296 0.39989297339799 1890 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.252624616223751 0.398824559582143 no 1297 0.400279152947028 1827 5355888
SGTC_2760 etidronate 98.04 µM 0.251819405879148 0.399145952591939 no 1298 0.400590328431252 1834 3305 A chelator and antioxidant.
SGTC_2628 lathosterol 100 µM 0.251577898865243 0.39924236144693 no 1299 0.400683671710712 1857 6710616
SGTC_746 1095-0025 46.6 µM 0.251128695115297 0.399421698540367 no 1300 0.400857305563864 1920 6749286
SGTC_2645 abamectin 100 µM 0.250186831801877 0.399797790601338 no 1301 0.401221434103615 1936 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1234 0326-0494 15.5 µM 0.249630464583845 0.400019995305242 no 1302 0.401436568477736 1950 1547813
SGTC_3219 9131112 49.47 µM 0.248746943284026 0.400372926933206 no 1303 0.401778267169713 1944 17612988 YMR079W SEC14
SGTC_1339 1486-1321 22.7 µM 0.245678856954382 0.401599135545765 no 1304 0.40296542017886 1858 3469382
SGTC_854 0422-0053 192 µM 0.24545178643707 0.401689926503613 no 1305 0.403053317639876 1916 3596728
SGTC_2593 nobiletin 86.24 µM 0.244641478658052 0.402013959914721 no 1306 0.40336702220406 1815 72344 An anti-infammatory.
SGTC_2449 5812982 45.77 µM 0.244535094236974 0.402056506913644 no 1307 0.403408212755627 1897 776185
SGTC_767 0929-0023 86 µM 0.244108661766985 0.402227064412193 no 1308 0.403573332162257 1863 1204563
SGTC_2883 9059145 45.46 µM 0.243174886847791 0.402600605437044 no 1309 0.403934960212774 1842 16476510
SGTC_1782 st039423 80.636 µM 0.242877445648102 0.402719610503304 no 1310 0.404050169131174 1818 2068169
SGTC_454 lyso-paf C-16 6.67 µM 0.242059022335177 0.403047104977096 no 1311 0.404367214764901 1792 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3227 9130768 49.47 µM 0.24161187834824 0.403226059695803 no 1312 0.404540458578173 1924 17720899
SGTC_1687 st020778 55.3625 µM 0.240230897325665 0.40377887987811 no 1313 0.405075631142965 1901 4259299
SGTC_860 0443-0016 25.1 µM 0.240024335264948 0.403861585244049 no 1314 0.405155695576724 2014 5337942
SGTC_1924 st058459 75.1 µM 0.239652358396624 0.404010531868005 no 1315 0.405299885582657 1931 688683
SGTC_1910 st062352 60.4 µM 0.238372017076153 0.404523311192788 no 1316 0.405796284547221 1850 2245730
SGTC_2433 5607874 27.82 µM 0.237096666505052 0.405034254802505 no 1317 0.406290899195837 1845 2252428
SGTC_46 0329-0187a 2.197 µM 0.236470452745448 0.405285194105546 no 1318 0.406533816240761 1927 46494817
SGTC_1671 st016596 74.5 µM 0.236136343279127 0.405419095949265 no 1319 0.406663436682015 1890 2829167
SGTC_34 0469-0683 81.75 µM 0.235869239478446 0.405526151736834 no 1320 0.406767069095738 1937 3690923
SGTC_236 1509-0011 5.31 µM 0.233732725345266 0.406382724991004 no 1321 0.407596240095824 1974 3107280
SGTC_904 1141-0088 396 µM 0.233091527554691 0.406639882241065 no 1322 0.407845166880349 1812 1378119
SGTC_2233 sulbentine 40.3845 µM 0.232573002311063 0.406847870186173 no 1323 0.408046496756315 1956 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3078 9116413 49.47 µM 0.230867568173729 0.40753212941952 no 1324 0.408708843492923 1923 17177322
SGTC_1458 k015-0034 6.33 µM 0.230732379580653 0.407586382278696 no 1325 0.408761358445572 1809 3598957
SGTC_1037 k284-1091 78.7 µM 0.229222378595085 0.408192484638275 no 1326 0.409348039991765 1855 3334711
SGTC_1468 k284-1086 134 µM 0.228445220439665 0.408504515464912 no 1327 0.409650068939115 1891 15996457
SGTC_593 1203-0218 61.7 µM 0.228343524447665 0.408545350941444 no 1328 0.409689595282231 2014 3666956
SGTC_189 3970-0742 2.116 µM 0.22683224506033 0.409152313812918 no 1329 0.41027709460975 2017 2891807
SGTC_715 0868-0130 184 µM 0.225622723512993 0.409638241175371 no 1330 0.410747432859701 2043 2876258
SGTC_2975 9084847 53.72 µM 0.225362745528208 0.409742705931915 no 1331 0.41084854547827 1857 27211724
SGTC_55 0767-0285 6.563 µM 0.22530583497335 0.409765574674319 no 1332 0.410870680355457 2020 3116166
SGTC_1903 st060211 78.3 µM 0.225135665839906 0.409833956686884 no 1333 0.410936867888164 2020 688960
SGTC_513 4245-1575 41.7 µM 0.224951535535981 0.409907952047839 no 1334 0.411008488494807 1983 719745
SGTC_442 cape 100 µM 0.224759121454265 0.409985279790028 no 1335 0.411083334387184 2026 5281787
SGTC_3022 9087993 49.47 µM 0.224481391180712 0.410096900740452 no 1336 0.41119137257307 1956 17173644
SGTC_1413 3910-0535 34.4 µM 0.22124230358352 0.411399239124275 no 1337 0.412451885892264 2002 2876951
SGTC_2996 9066192 71.4286 µM 0.220992791376729 0.411499601082818 no 1338 0.412549022937458 1829 6472854
SGTC_789 1309-1135 70.6 µM 0.220546417024425 0.411679161868895 no 1339 0.412722813307796 1916 3092424
SGTC_45 0kpi-0036 14.9 µM 0.219861636206228 0.411954661179284 no 1340 0.412989457553048 1931 2795021
SGTC_2183 6420625 130.508 µM 0.219803142074244 0.411978196406484 no 1341 0.413012236227524 1948 2897619
SGTC_1945 st075991 56.6 µM 0.219062044404025 0.412276405877586 no 1342 0.41330085841954 1865 1084980
SGTC_2153 5569715 200 µM 0.217438664215286 0.412929812816904 no 1343 0.413933251108404 1943 2054701
SGTC_1688 st021091 57.6 µM 0.217123336767972 0.413056759461173 no 1344 0.414056113819305 2047 3656366
SGTC_823 0417-1665 178 µM 0.216997211464978 0.413107538380112 no 1345 0.414105259048018 1928 3429856
SGTC_807 1315-0151 48 µM 0.216141251275382 0.413452192239142 no 1346 0.414438822860655 2058 4011080
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.215434902580824 0.413736655011437 no 1347 0.414714130240159 1999 16725076
SGTC_288 1315-0019 35.1 µM 0.21527494263625 0.413801080831881 no 1348 0.414776482257824 1937 6811474
SGTC_2504 purpurogallin 52.29 µM 0.213880727341725 0.414362716125402 no 1349 0.415320034915979 1884 5281571 An antioxidant.
SGTC_1876 myriocin 605 nM 0.212869961659236 0.414769995021605 no 1350 0.41571419626133 2047 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1619 st003326 88.7 µM 0.211803215910499 0.415199929959697 no 1351 0.416130279754502 2016 2849032
SGTC_802 4112-3352 742 µM 0.210774168004042 0.415614767633933 no 1352 0.416531748328984 2016 704594
SGTC_475 α-linolenic acid 10 µM 0.209906141806893 0.41596476616208 no 1353 0.416870464275977 2037 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1032 k061-1018 98.7 µM 0.209580638782198 0.416096030069253 no 1354 0.416997496028077 2078 4005393
SGTC_1211 1056-0033 32.3 µM 0.208791842959178 0.416414162443008 no 1355 0.417305369689377 2056 6741922
SGTC_1761 st044296 37 µM 0.208127983190989 0.416681948808685 no 1356 0.417564519060058 1932 1826700
SGTC_2427 5545055 42.75 µM 0.206924973422944 0.417167314820448 no 1357 0.418034226308589 1954 5372858
SGTC_338 4055-0136 114 µM 0.204845676553146 0.418006524715318 no 1358 0.418846349451864 1896 2900563
SGTC_1441 4106-0040 13 µM 0.204322028729605 0.418217929427963 no 1359 0.419050928316106 2033 2904180
SGTC_3354 9151612 71.43 µM 0.20350200140143 0.418549034575557 no 1360 0.419371340759578 2038 27261949
SGTC_2532 xanthone 78.9 µM 0.202758000064361 0.418849492403026 no 1361 0.41966209354691 2020 7020 An insecticide.
SGTC_894 0960-0238 55.9 µM 0.20155299132875 0.419336224018867 no 1362 0.420133099193244 2054 6741907 YDL195W SEC31
SGTC_1140 3229-1848 2.98 µM 0.200297447667601 0.419843499218461 no 1363 0.420623979285043 2062 2849525
SGTC_2916 7875993 68.79 µM 0.199237333384614 0.420271919174755 no 1364 0.421038548486428 2108 1299250
SGTC_567 1080-0542 68.4 µM 0.199231478411041 0.420274285585773 no 1365 0.421040838380995 2055 5950415
SGTC_1265 0819-1001 68.8 µM 0.198685741830169 0.420494869173201 no 1366 0.421254289017955 2015 3106768
SGTC_2949 9072542 2.23 µM 0.198416995383921 0.42060350412122 no 1367 0.42135941069382 1913 16457352
SGTC_3073 9114972 49.47 µM 0.198045786965217 0.420753567052647 no 1368 0.421504620160735 2080 41905075
SGTC_1693 xanthone 101.9 µM 0.197991685459017 0.420775438829572 no 1369 0.42152578450271 2004 7020 An insecticide.
SGTC_535 2293-4129 48.2 µM 0.197048104229741 0.421156942491193 no 1370 0.421894946967593 2059 396118 YIL048W NEO1
SGTC_787 4152-0075 138 µM 0.196057781413464 0.421557424086436 no 1371 0.422282470224521 1931 9566539
SGTC_537 1334-0398 209 µM 0.19510762135593 0.42194174035331 no 1372 0.4226543481288 2081 5846986
SGTC_2961 9083290 32.55 µM 0.19450317565756 0.422186262419515 no 1373 0.422890954698322 2052 17741490
SGTC_3138 9097216 49.47 µM 0.194043662211504 0.422372173762687 no 1374 0.423070847042022 2132 25237486
SGTC_1568 digitonin 820 nM 0.192581042399338 0.422964039867273 no 1375 0.423643546485022 2104 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.19224394068172 0.423100476705302 no 1376 0.423775564038718 1874 23665772 A membrane-active detergent.
SGTC_3319 9138450 16.7555 µM 0.191830202888572 0.42326794344462 no 1377 0.423937605909709 1949 2029690
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.190463009146041 0.423821434594106 no 1378 0.424473163502786 1914 688669
SGTC_1811 st050069 61.5 µM 0.19044229809134 0.42382982036203 no 1379 0.424481277518987 2107 3877702
SGTC_1648 st011736 69.8 µM 0.190189444854708 0.423932201731262 no 1380 0.424580340976206 2043 2855514
SGTC_549 1661-1316 519 µM 0.189531198019856 0.424198752786444 no 1381 0.424838252854222 2091 2857282
SGTC_2317 5986382 200 µM 0.189505200092775 0.424209281122652 no 1382 0.424848439928613 2035 877883
SGTC_2250 alverine citrate 130 µM 0.189412884588087 0.424246666412163 no 1383 0.424884613407067 1901 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2571 chrysanthemic acid 100 µM 0.189223236845466 0.424323470770993 no 1384 0.424958928135884 1880 2743 An insecticide.
SGTC_1154 4088-0362 150 µM 0.188219624997118 0.424729965593682 no 1385 0.425352244449484 2053 6618304
SGTC_2367 9070478 135.38 µM 0.187650468640122 0.424960527682433 no 1386 0.425575330338948 1952 572802
SGTC_2456 5770359 74.46 µM 0.187002081873793 0.425223216847847 no 1387 0.425829500320808 2057 3118787
SGTC_1797 st048695 56.8 µM 0.186712209813755 0.425340667143789 no 1388 0.425943141203033 2074 592262 YIL048W NEO1
SGTC_1131 3454-3128 32.3 µM 0.186456819559627 0.425444151600297 no 1389 0.426043269001751 2010 710982
SGTC_2152 5568786 200 µM 0.185348014600951 0.425893500252623 no 1390 0.426478040092117 2021 5399883
SGTC_3129 9127257 49.47 µM 0.185168983902777 0.425966062361762 no 1391 0.426548247820721 1828 837894
SGTC_850 0388-0143 75.9 µM 0.184769110946907 0.426128142079961 no 1392 0.426705068278893 1962 67273
SGTC_2269 7935389 174.42 µM 0.184352100331307 0.426297181464536 no 1393 0.426868622052981 1894 97605
SGTC_152 4469-0003 551.229 µM 0.184042252204335 0.426422790243101 no 1394 0.426990154274766 2120 697280
SGTC_1466 k213-0079 57.5 µM 0.182865916442936 0.426899730744853 no 1395 0.427451613321093 1974 3657981
SGTC_2974 9094440 9.66 µM 0.181773868462093 0.427342592805718 no 1396 0.427880096396949 2028 25236134
SGTC_1864 st057645 30.4 µM 0.179029610332035 0.428455884467416 no 1397 0.428957225803489 2123 688666
SGTC_3326 9140064 16.379 µM 0.17852467525781 0.428660789022334 no 1398 0.429155472198885 1959 1868434
SGTC_1502 4534-4282 27.7 µM 0.176669102707597 0.429413952129645 no 1399 0.429884155770905 1986 3278949
SGTC_2181 6316240 54.2555 µM 0.174970442523074 0.430103651084523 no 1400 0.430551429364172 1951 12779990
SGTC_3279 9140807 49.47 µM 0.174367512987765 0.430348507116294 no 1401 0.430788322031776 2097 45595718
SGTC_800 3448-7362 155 µM 0.173994256937151 0.430500103757402 no 1402 0.43093498784477 2126 15991913
SGTC_1967 st070177 51.4 µM 0.173342021791519 0.430765031359153 no 1403 0.431191297495835 2068 5729214
SGTC_27 0485-0001 32.618 µM 0.169952223137499 0.432142413156795 no 1404 0.432523855172043 2110 2054479
SGTC_1267 0828-0272 9.49 µM 0.168109145455756 0.432891660974323 no 1405 0.433248707355791 2099 745334
SGTC_1401 3807-4679 7.6 µM 0.166658800188497 0.433481425042897 no 1406 0.433819262376063 2045 3291456
SGTC_297 0986-0032 24 µM 0.166576440248197 0.433514920100649 no 1407 0.433851666312427 2003 2847425
SGTC_1614 st002383 48.6 µM 0.16635782710724 0.433603830442781 no 1408 0.433937680263052 2158 1947235
SGTC_2850 9015429 58.44 µM 0.165466017708709 0.433966565629703 no 1409 0.43428859752774 2011 6457570
SGTC_520 3584-0023 682 µM 0.165360111767036 0.434009645587747 no 1410 0.434330273805272 1948 1340790
SGTC_988 1497-1057 103 µM 0.165059850129202 0.434131788969683 no 1411 0.434448437217393 2143 3533044
SGTC_2930 9013230 14.89 µM 0.164604409667749 0.434317069519989 no 1412 0.434627680076436 2082 2995857
SGTC_1059 3448-6867 171 µM 0.164387392134297 0.434405360842991 no 1413 0.434713094088563 2156 3934407
SGTC_2702 st077768 96.8 µM 0.164069615538938 0.434534650842761 no 1414 0.434838170465667 1983 6484119
SGTC_2003 4023581 200 µM 0.164036270219432 0.434548218064126 no 1415 0.434851295510189 1983 16641307
SGTC_1006 4099-6547 255 µM 0.163301349029504 0.434847255238338 no 1416 0.435140585894643 2066 3146833
SGTC_304 1310-0298 97 µM 0.162690466862881 0.43509584969052 no 1417 0.435381076663556 2014 1550234
SGTC_1825 st052143 62.6 µM 0.162640923450288 0.435116012180268 no 1418 0.43540058185601 2105 674173
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.162511644618486 0.4351686250775 no 1419 0.435451479544034 2122 77254
SGTC_596 1155-0152 116 µM 0.162117704492437 0.435328954851459 no 1420 0.435606582226812 2007 280313
SGTC_2490 carminic acid 95.39 µM 0.161919440710821 0.435409650292873 no 1421 0.435684646681742 2047 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2718 lomofungin 53.02 µM 0.161640296609844 0.435523269432434 no 1422 0.435794561231126 2089 5351222 A RNA synthesis inhibitor.
SGTC_464 bw-b 70c 158 µM 0.161507916892701 0.435577153390748 no 1423 0.435846688218584 2111 5353454
SGTC_246 cycloheximide 667 µM 0.160102154532757 0.436149429752928 no 1424 0.43640030199901 2031 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2570 licareol 100 µM 0.158703282815335 0.436719033702706 no 1425 0.436951325824418 1984 443158
SGTC_1529 apigenin 74 µM 0.157714104421144 0.437121894674434 no 1426 0.437341042937707 2124 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3210 9128157 49.47 µM 0.15751662419434 0.437202329926288 no 1427 0.437418853612161 1860 17590849
SGTC_2026 5148700 152 µM 0.156514991919667 0.437610342544557 no 1428 0.437813551514063 2034 79838
SGTC_1623 st003709 20.3 µM 0.156499601002218 0.437616612518304 no 1429 0.437819616861093 1975 16192618
SGTC_587 k089-0003 57 µM 0.155784259380902 0.437908046658588 no 1430 0.43810153916515 2148 9659696
SGTC_1166 k206-0078 225 µM 0.154851069355167 0.438288284054162 no 1431 0.438469364611403 2061 5404595
SGTC_2191 5911152 200 µM 0.154815303595191 0.438302858298505 no 1432 0.438483463074898 2090 2875902
SGTC_231 b-estradiol 524 µM 0.154801456694321 0.43830850081583 no 1433 0.438488921389674 1997 450 A steroid.
SGTC_256 clotrimazole 625 nM 0.152811922530999 0.439119352160596 no 1434 0.43927329767299 2134 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3124 9127567 49.47 µM 0.152554671108197 0.439224215865552 no 1435 0.439374736839599 2140 17592030
SGTC_2300 7976697 71.57 µM 0.15133994643011 0.439719433037567 no 1436 0.439853779733431 1997 2236109
SGTC_97 0535-0701 19.132 µM 0.151129653032167 0.439805174742088 no 1437 0.439936720705207 2099 2832013 YGL099W LSG1
SGTC_227 fluconazole 33.516 µM 0.149871917521521 0.440318042733562 no 1438 0.440432834005395 2001 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3113 9123498 49.47 µM 0.149694432419525 0.44039042408336 no 1439 0.440502850485103 2168 8897275
SGTC_1264 0783-0040 158 µM 0.148697292203117 0.440797111261361 no 1440 0.440896248996505 1992 2855798
SGTC_1733 st037357 54.9 µM 0.148552886545266 0.440856012808534 no 1441 0.44095322573938 2016 1272339 YGL099W LSG1
SGTC_2000 st075254 36.4 µM 0.147859222677232 0.441138969211624 no 1442 0.441226934995249 2100 17234175
SGTC_2253 7938677 135.83 µM 0.146761399317383 0.441586849984953 no 1443 0.44166017678952 2165 2301972
SGTC_2359 9039622 200 µM 0.146714175668831 0.441606117573153 no 1444 0.441678814561504 2074 6463596
SGTC_2156 5649887 115 µM 0.146491161175946 0.441697110956379 no 1445 0.441766833504571 2132 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1292 0kpi-0043 232 µM 0.146091875240401 0.441860033514212 no 1446 0.441924430111383 2037 3333905
SGTC_3133 9127736 49.47 µM 0.145303071153372 0.442181921918515 no 1447 0.442235795015397 2189 27243420
SGTC_2130 NSC 7 2.4545 µM 0.144976464819303 0.442315211818026 no 1448 0.442364726902844 2132 21448
SGTC_2007 4011539 71.82 µM 0.143734286692546 0.442822211289184 no 1449 0.442855147722465 2062 45595301
SGTC_2303 7774051 200 µM 0.142935842001025 0.443148148856222 no 1450 0.443170425684924 2126 2953184
SGTC_592 k241-0073 46.5 µM 0.141584391114888 0.443699919728087 no 1451 0.443704148401445 2155 4230158
SGTC_2987 9018338 71.43 µM 0.141527608578457 0.443723105320379 no 1452 0.443726575528096 2177 5055682
SGTC_2059 5238311 157 µM 0.141290832564211 0.443819788391111 no 1453 0.443820095759109 2053 703021
SGTC_616 4092-0450 108 µM 0.141138072327135 0.443882166960703 no 1454 0.443880433652413 2089 787165
SGTC_3345 9148410 3.559 µM 0.139829420702026 0.444416602473702 no 1455 0.444397383647034 2153 4903596
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.13928232287043 0.444640059798503 no 1456 0.444613529012912 2140 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2524 avocatin b 10.57 µM 0.138449189994582 0.444980379412025 no 1457 0.444942711652923 2147 6710748
SGTC_2793 7325131 81.82 µM 0.137693651013245 0.445289038405594 no 1458 0.445241268680578 2079 4176441
SGTC_1197 1601-0112 267 µM 0.137318123256583 0.445442464442536 no 1459 0.445389672922426 2027 7350313
SGTC_1932 st074806 40.9 µM 0.137301204266077 0.445449377076613 no 1460 0.445396359292818 2091 17251235
SGTC_2844 9010103 25.97 µM 0.137270692161718 0.445461843524985 no 1461 0.445408417689292 2041 2480525
SGTC_2871 9038510 12.99 µM 0.136969242459083 0.445585010891091 no 1462 0.445527553451158 2182 4945164
SGTC_2517 totarol 10 µM 0.1362834595467 0.445865230000516 no 1463 0.445798599625411 2017 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1613 st002381 52.1 µM 0.135277641623641 0.446276268126588 no 1464 0.446196180984357 2204 551167
SGTC_2620 irigenin 100 µM 0.134908275237128 0.446427228122314 no 1465 0.44634219833816 2109 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_331 k048-0133 24.5 µM 0.134806546486227 0.446468806014664 no 1466 0.446382414870845 2076 6813582
SGTC_343 4130-2827 29.8 µM 0.133827964010506 0.446868795670499 no 1467 0.446769307007017 2033 1118244
SGTC_400 oxethazaine 37.5 µM 0.130925832539757 0.448055340643112 no 1468 0.447916989582359 2064 4621 A local anesthetic.
SGTC_992 3909-8734 162 µM 0.130159415971977 0.448368770342073 no 1469 0.448220151364796 2054 4288319
SGTC_155 k072-0202 43.6 µM 0.128481838860703 0.449054935699783 no 1470 0.448883834795578 2175 5857737
SGTC_2086 5274770 176.623 µM 0.128420100598394 0.449080190905625 no 1471 0.448908262441346 2068 689278
SGTC_1301 naphtanilide LB 4.81 µM 0.128193092662934 0.449173054575475 no 1472 0.448998083113247 2179 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1168 k815-0004 80.5 µM 0.127891867288117 0.449296283172226 no 1473 0.449117273578609 2108 642433
SGTC_1612 st002233 45.4 µM 0.127118578659744 0.449612650972636 no 1474 0.449423273552774 2184 1035021
SGTC_3052 9092717 49.47 µM 0.126285242970339 0.449953621076117 no 1475 0.449753068569721 2081 25237534
SGTC_1419 3993-2473 62.6 µM 0.125231384407803 0.450384873851596 no 1476 0.450170185826453 2100 704026
SGTC_1445 4239-0156 97.7 µM 0.124102731761514 0.450846798309942 no 1477 0.450616967624879 2177 4008346
SGTC_2917 7979103 53.79 µM 0.123417683578681 0.451127200969172 no 1478 0.450888177326599 2144 2980565
SGTC_409 arachidonic acid 100 µM 0.122845134447402 0.451361574440852 no 1479 0.451114866394133 2178 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_204 PMA1.184 62.41 µM 0.122471729028506 0.451514437405691 no 1480 0.451262717194395 2195 2252213 YGL008C PMA1
SGTC_1075 aripiprazole 15.2 µM 0.121950309084798 0.451727905889347 no 1481 0.451469186020972 2109 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1860 st056228 74.6 µM 0.121658755893025 0.451847273383985 no 1482 0.451584639279091 2069 688679
SGTC_2924 9010168 62.78 µM 0.121020220124267 0.452108717424767 no 1483 0.451837509781188 2087 2993929
SGTC_161 4065-0411 162.148 µM 0.119596381602642 0.452691772854733 no 1484 0.452401443106921 2108 1906281 YLR208W SEC13
SGTC_1218 1348-1416 30.7 µM 0.119365770298167 0.452786216773152 no 1485 0.452492789356777 2151 6787668
SGTC_270 tamoxifen 5.46 µM 0.117473950291853 0.453561087881129 no 1486 0.453242242875402 2221 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1060 3448-7350 82 µM 0.117334753082696 0.453618108726445 no 1487 0.453297393125118 2185 570178
SGTC_1175 0741-0056 27.6 µM 0.117199300426366 0.453673596568375 no 1488 0.453351060639265 2183 765927
SGTC_1617 st002906 78 µM 0.116487959819042 0.453965010289358 no 1489 0.453632913904098 2119 5150859
SGTC_2431 5490079 200 µM 0.116448011283107 0.453981376675996 no 1490 0.453648743337729 2111 5722345
SGTC_1353 1498-1206 8.11 µM 0.115100284710767 0.454533568033194 no 1491 0.454182817119135 2179 6756808
SGTC_313 3474-0040 5.03 µM 0.114362376984812 0.454835941337286 no 1492 0.454475268545586 2159 1043375 YIL048W NEO1
SGTC_392 N-ethylmaleimide 8.33 µM 0.114221895364635 0.454893509624399 no 1493 0.454530947753084 2101 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1812 st052057 4.327 µM 0.113746266991293 0.455088425498746 no 1494 0.454719467374363 2173 3645418
SGTC_1021 4476-0760 85.3 µM 0.112036988892131 0.455788988684188 no 1495 0.455397039145846 2014 746768
SGTC_401 neomycin 50 µM 0.111313814465997 0.456085429819271 no 1496 0.455683750562775 2111 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1206 3978-0017 132 µM 0.110511163663443 0.456414478250515 no 1497 0.456001998387874 2117 3873677
SGTC_2118 5526350 200 µM 0.109652474366287 0.456766532872902 no 1498 0.456342496501852 2126 743594
SGTC_1378 2093-0007 380 nM 0.109644434759756 0.456769829197563 no 1499 0.456345684618079 2114 3618014
SGTC_1249 0481-0015 10.2 µM 0.109641379277118 0.456771081978904 no 1500 0.456346896274355 2150 4227577
SGTC_1224 0823-0416 294 µM 0.108106109752903 0.457400613379378 no 1501 0.456955760839494 2191 3598164
SGTC_363 0455-0021 3.06 µM 0.107985182136902 0.45745020384854 no 1502 0.457003723206711 2169 4597466
SGTC_2448 5185112 27.17 µM 0.107916523058286 0.457478360126614 no 1503 0.457030955081154 2106 5718189
SGTC_2670 beta-carotene 100 µM 0.107674773407233 0.457577500504023 no 1504 0.457126840526799 2216 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_951 1171-0579 82.7 µM 0.107096653942331 0.457814595228937 no 1505 0.45735615083439 2209 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2055 5235184 200 µM 0.106671487116709 0.457988971562887 no 1506 0.457524801748197 2153 2836034
SGTC_123 0083-0120 66.675 µM 0.106021168464925 0.458255706458354 no 1507 0.457782778418315 2045 16001701
SGTC_2678 equilin 100 µM 0.105273072144395 0.458562569116658 no 1508 0.458079564770541 2232 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_149 3970-0822 46.1 µM 0.104794746120278 0.458758787281021 no 1509 0.45826933954191 2204 3114250 YBL034C STU1
SGTC_209 4077-0173 175.592 µM 0.103811013582817 0.459162364058707 no 1510 0.458659663060509 2163 15993494
SGTC_138 0850-0259 40.9225 µM 0.103408479019859 0.459327516228158 no 1511 0.458819391470313 2232 6813004
SGTC_78 0336-0123 156.75 µM 0.103171746750907 0.459424646193076 no 1512 0.458913331526291 2014 6765896
SGTC_2099 5377090 177.372 µM 0.102716517334661 0.459611431153125 no 1513 0.459093982024327 2122 2243829
SGTC_1742 st038235 28.8875 µM 0.102549691720585 0.459679883523883 no 1514 0.459160186212627 2125 564103 YBR002C RER2
SGTC_2362 9071156 126 µM 0.102407037385759 0.45973841881319 no 1515 0.459216799007834 2198 653133
SGTC_2335 9018011 154.17 µM 0.102333221920089 0.459768707822855 no 1516 0.459246093218738 2181 6458208
SGTC_1312 1218-2183 165 µM 0.102274365614477 0.45979285874494 no 1517 0.459269450935427 2224 6744073
SGTC_1286 0929-0070 131 µM 0.101030217598568 0.460303413331084 no 1518 0.45976323635962 2171 1420408
SGTC_1789 tunicamycin 25 nM 0.100140774544774 0.460668449649285 no 1519 0.460116282302316 2211 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_90 0870-0863 4.608 µM 0.097167570628939 0.461888921118859 no 1520 0.461296660519404 2213 1738164
SGTC_1597 7-benzyloxygramine 47.5 µM 0.0962379308169505 0.462270603481775 no 1521 0.461665803087311 2139 260807
SGTC_69 0096-0274 206.684 µM 0.096169673705902 0.462298629188004 no 1522 0.4616929080138 2180 6741392
SGTC_897 1000-0139 31.4 µM 0.0960458865269531 0.462349455477704 no 1523 0.461742064406623 2238 6151020
SGTC_873 0591-4978 488 µM 0.0958320773678428 0.462437245712011 no 1524 0.461826970270423 2229 3305145
SGTC_2806 7952793 58.44 µM 0.0955384047704557 0.462557830928249 no 1525 0.461943593579824 2177 2972490
SGTC_81 0411-0046 9.971 µM 0.0953218637251759 0.46264674728092 no 1526 0.462029588491218 2208 12925265
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.0951008979689856 0.462737482437934 no 1527 0.462117342417158 2147 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2653 dihydrofissinolide 100 µM 0.0924936152687036 0.463808255932058 no 1528 0.463152931877361 2183 6857746
SGTC_3330 9141424 71.43 µM 0.0922005473795462 0.463928631234809 no 1529 0.463269351576471 2233 27261020
SGTC_3275 9138069 49.47 µM 0.0919499301678464 0.464031572879462 no 1530 0.463368910459809 2134 17617007
SGTC_451 chloral hydrate 100 µM 0.0916889560019506 0.464138771228082 no 1531 0.463472586131 2135 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_129 0088-0017 176.636 µM 0.0915594049056411 0.464191986901797 no 1532 0.463524053054557 2245 182446
SGTC_981 1488-1094 54.9 µM 0.09132573390474 0.464287973503626 no 1533 0.463616885363858 2224 3449522
SGTC_2463 5473429 200 µM 0.0911623346059479 0.464355095363024 no 1534 0.463681801460804 2147 5399405
SGTC_1330 1469-0054 61.8 µM 0.0908887956754083 0.464467463118745 no 1535 0.463790476549246 2261 7102664
SGTC_3005 9076496 71.4286 µM 0.0898756757807879 0.4648836698436 no 1536 0.464193005412142 2265 21368410
SGTC_1268 0828-0275 2.46 µM 0.0873184174991577 0.46593440451082 no 1537 0.465209207443303 2214 745337
SGTC_1232 0279-0259 161 µM 0.0860240150947211 0.466466343810996 no 1538 0.465723663350607 2168 1560000
SGTC_3054 9094397 49.47 µM 0.0859008220755604 0.46651697356009 no 1539 0.465772629003174 2213 2598354
SGTC_908 3448-7491 47.7 µM 0.0858828140046877 0.466524374545231 no 1540 0.465779786732545 2197 1203031
SGTC_2589 lobaric acid 100 µM 0.0844214854332381 0.467124992002641 no 1541 0.466360662678282 2157 73157 A novel microtubule depolymerizer.
SGTC_1250 0485-0349 40.2 µM 0.0843791392783774 0.467142397725741 no 1542 0.466377496286597 2186 6842794 YDL195W SEC31
SGTC_31 0508-1974 57.237 µM 0.0837112634274447 0.4674169259125 no 1543 0.466643000830427 2230 6810525
SGTC_1317 1273-0028 910 nM 0.0810848146021204 0.468496668210501 no 1544 0.467687251055723 2202 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3158 9100007 49.47 µM 0.0807751135191272 0.468624002839008 no 1545 0.467810399958782 2186 19297233
SGTC_1558 st069300 45.6 µM 0.0804106858818733 0.468773842581705 no 1546 0.467955314161115 2269 24208000
SGTC_943 3253-1379 105 µM 0.079768771476648 0.469037785804082 no 1547 0.468210580952007 2234 668464
SGTC_121 0557-0495 61.343 µM 0.0795115078974536 0.469143571612427 no 1548 0.468312889307647 2247 3104427
SGTC_2889 9059656 51.95 µM 0.0787683356679352 0.46944917342451 no 1549 0.468608445122282 2218 3949838
SGTC_414 piperonyl butoxide 100 µM 0.0783857156663774 0.469606518634272 no 1550 0.468760617907467 2207 5794 A potent inhibitor of cytochrome P450.
SGTC_463 ikarugamyin 104 µM 0.0776201337256948 0.469921363894408 no 1551 0.469065113150804 2274 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1482 3346-2049 8.48 µM 0.0772872443766712 0.470058270381178 no 1552 0.469197519033635 2257 3826804
SGTC_2293 7624732 200 µM 0.0746512651287589 0.471142485985123 no 1553 0.470246092103838 2272 894453
SGTC_247 mechlorethamine 29.705 µM 0.0745646925700694 0.471178098177039 no 1554 0.470280533567664 2225 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_743 1275-0778 158 µM 0.0742789057740778 0.471295660091511 no 1555 0.470394230705282 2263 2849257 YMR203W TOM40
SGTC_104 0074-0074 590.992 µM 0.0736906407377868 0.47153765801357 no 1556 0.470628273075308 2283 3943124
SGTC_2064 5220758 200 µM 0.0729807575361238 0.471829700674211 no 1557 0.470910714966726 2198 788518
SGTC_2492 derrusnin 100 µM 0.0725586954685919 0.472003342243722 no 1558 0.471078648140572 2222 1715307 Part of coumarin class of compounds.
SGTC_1467 k284-1082 293 µM 0.0707621502792799 0.472742522352786 no 1559 0.471793527989575 2297 3334705
SGTC_2266 7929956 200 µM 0.0704415761311559 0.472874431029178 no 1560 0.471921100224423 2296 2967153
SGTC_720 r052-1644 49.9 µM 0.0700557482793328 0.473033194003987 no 1561 0.472074643939246 2227 1422863 YOR257W CDC31
SGTC_2906 7926292 26.41 µM 0.0694065732968108 0.473300330438177 no 1562 0.472332998402601 2197 2966319
SGTC_426 0988-0037 14.6 µM 0.0692147754401641 0.473379257833967 no 1563 0.472409331106419 2309 5383008
SGTC_1138 3761-0006 1.03 µM 0.068663508463811 0.473606117411734 no 1564 0.472628732823471 2276 12061087
SGTC_3323 9138564 53.9225 µM 0.0681425415392811 0.473820515660298 no 1565 0.472836082893366 2284 43912313 YNL103W MET4
SGTC_840 0245-0196 390 µM 0.0671504556109167 0.474228818708503 no 1566 0.473230963369267 2252 3827528
SGTC_1999 st074831 12.5 µM 0.0666644159257951 0.474428863188325 no 1567 0.473424431622245 2141 17112523
SGTC_3135 9127742 49.47 µM 0.0642931889432782 0.475404905612629 no 1568 0.474368388336018 2169 3643468
SGTC_690 glyoxal 20.3 µM 0.064112529939492 0.475479274442874 no 1569 0.474440312462122 2238 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1857 st056007 79.3 µM 0.0633192127780931 0.475805855950927 no 1570 0.474756158438282 2293 619834
SGTC_1478 0453-0656 35.7 µM 0.0630237400822662 0.475927496107292 no 1571 0.474873800022249 2289 5258496
SGTC_541 4513-1321 94 µM 0.0619511956562942 0.476369059809121 no 1572 0.475300848761429 2132 747515
SGTC_1935 st074532 41.6 µM 0.0612772529034042 0.476646535137671 no 1573 0.475569203152728 2269 2829742
SGTC_538 2922-0838 53.3 µM 0.0607097006486294 0.47688021621953 no 1574 0.475795202966519 2303 777039
SGTC_10 0279-0212 42.575 µM 0.0606192773272427 0.476917447394801 no 1575 0.475831210334743 2299 39851 YBR002C RER2
SGTC_893 0958-0369 48.9 µM 0.0604861287755515 0.476972270753938 no 1576 0.475884231627662 2305 6819948
SGTC_1849 st056239 19.2 µM 0.0598279146843161 0.477243294035217 no 1577 0.476146346344957 2198 5393181
SGTC_1821 st053465 65.6 µM 0.0584178546338913 0.477823929303117 no 1578 0.476707896558629 2238 675086
SGTC_2603 homopterocarpin 100 µM 0.057719197762386 0.478111640114442 no 1579 0.476986150792621 2253 101795 A weak amylase inhibitor.
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.0572640600104276 0.478299074534604 no 1580 0.477167424654929 2298 1273210
SGTC_2591 skatole 100 µM 0.0570700383450511 0.478378977824144 no 1581 0.477244701723723 2254 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.0566046787568861 0.478570628833142 no 1582 0.477430053707009 2224 4213774
SGTC_2967 9089538 49.85 µM 0.0564447139987536 0.478636508943236 no 1583 0.477493768545219 2313 728216
SGTC_359 0081-0058 15.9 µM 0.0563636741599593 0.478669884726854 no 1584 0.477526047375971 2274 3494159
SGTC_926 2268-1401 59.4 µM 0.0563611727653148 0.478670914913989 no 1585 0.477527043704268 2331 2931578
SGTC_2716 st080858 38.6235 µM 0.0560194372601508 0.478811658344957 no 1586 0.477663161390011 2311 5296050
SGTC_2795 7780010 54.55 µM 0.0557950888536924 0.478904057452772 no 1587 0.477752523689129 2255 953673
SGTC_1271 0832-2808 169 µM 0.0549430664130193 0.479254977802473 no 1588 0.478091910819923 2307 3663794
SGTC_3308 9128332 17.569 µM 0.0548276357311914 0.479302521191345 no 1589 0.478137891690723 2299 17332805 YDL196W YDL196W
SGTC_3067 9117431 49.47 µM 0.0547971533720962 0.479315076261678 no 1590 0.478150034138488 2253 17150885
SGTC_2743 auranofin 4.32 µM 0.0532391599773686 0.479956809445728 no 1591 0.478770677346256 2288 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1740 st038286 13.222 µM 0.0529531765594642 0.480074610919845 no 1592 0.478884607513384 2278 716786
SGTC_2958 9077254 16.72 µM 0.0511627810911752 0.4808121446584 no 1593 0.479597904684562 2253 16457351
SGTC_2724 maprotiline 69.64 µM 0.0507378875477356 0.480987184622678 no 1594 0.479767192809158 2300 4011 A tricyclic antidepressant.
SGTC_1721 st082152 9.2685 µM 0.0505935341969041 0.48104665354367 no 1595 0.479824707596038 2325 5296051
SGTC_651 3253-0966 34.4 µM 0.0493175703479109 0.481572327654574 no 1596 0.480333108721232 2297 781462
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0491105893319272 0.481657603147551 no 1597 0.480415582262585 2245 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.0483609008337269 0.481966479322126 no 1598 0.480714309719248 2302 688798
SGTC_1709 st033179 39.1045 µM 0.0480592064549521 0.482090782287597 no 1599 0.480834528574148 2323 573381
SGTC_648 0375-0473 33.3 µM 0.0476579488953696 0.482256109590137 no 1600 0.480994423958363 2278 1713139
SGTC_1727 st034309 9.9045 µM 0.0457509216591664 0.483041889705746 no 1601 0.481754388328802 2332 870305
SGTC_3082 9117008 49.47 µM 0.0446984069426315 0.483475601029959 no 1602 0.482173851753189 2249 41448529
SGTC_3284 9108171 64.8615 µM 0.044211639625939 0.483676190614902 no 1603 0.482367852023451 2270 8687505
SGTC_1893 st059353 36.1 µM 0.0429030178057666 0.484215474582311 no 1604 0.482889421553125 2186 3112488
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.0418157597725905 0.48466355638206 no 1605 0.483322785759922 2341 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1201 1889-3372 45.9 µM 0.0416430687078266 0.484734727782478 no 1606 0.483391619569249 2247 5392199
SGTC_3058 9093861 49.47 µM 0.0412138591332251 0.484911620602392 no 1607 0.48356270253503 2306 17217477
SGTC_2772 vinpocetine 57.06 µM 0.0400871053697298 0.485376010700765 no 1608 0.484011840981763 2315 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2224 6650123 117.647 µM 0.0395895241694308 0.485581094496201 no 1609 0.484210189697219 2330 2908370
SGTC_581 0958-0271 211 µM 0.0390604209377533 0.485799174640843 no 1610 0.484421108193686 2333 4591145
SGTC_2155 5570423 76 µM 0.0387760851728954 0.485916370891988 no 1611 0.484534455879298 2285 797402
SGTC_1627 st003713 25.6 µM 0.0381127927954874 0.486189768505694 no 1612 0.484798875772871 2292 16195070 YER133W GLC7
SGTC_2487 5918373 44.05 µM 0.0379737840119392 0.486247066342317 no 1613 0.484854292137593 2348 2876279
SGTC_2476 5806916 10.51 µM 0.037589212166627 0.486405583950528 no 1614 0.485007604644213 2309 2870194
SGTC_1269 0831-0796 3.05 µM 0.037351555667512 0.486503545238823 no 1615 0.48510234933417 2345 927758
SGTC_2311 7694451 200 µM 0.0372084513544513 0.486562532795956 no 1616 0.485159400036836 2306 2163142
SGTC_505 gw-5074 63.9 µM 0.0370218838429069 0.486639436312444 no 1617 0.485233778458122 2312 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_412 gemfibrozil 100 µM 0.0358567187697529 0.487119730908046 no 1618 0.485698303537324 2345 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1408 3909-7976 48.8 µM 0.0354299185559847 0.487295667632342 no 1619 0.485868464062359 2321 24152374
SGTC_1508 1080-0625 72.9 µM 0.0353075067968412 0.487346128992491 no 1620 0.485917268753108 2335 767111
SGTC_977 1348-1378 135 µM 0.0350379793116125 0.487457236053383 no 1621 0.486024728171611 2347 X977
SGTC_938 3126-1755 342 µM 0.0342496923753547 0.487782196388833 no 1622 0.486339020488747 2339 1777771
SGTC_1695 st026914 34.495 µM 0.033391386756733 0.488136030170409 no 1623 0.486681239103275 2336 3289191
SGTC_1979 st071809 45.3 µM 0.033064353646459 0.488270851009725 no 1624 0.486811634433422 2317 4976333
SGTC_2485 5633444 17.78 µM 0.032506107190962 0.488500993656795 no 1625 0.48703422288539 2309 5724239
SGTC_449 xestospongin c 11.1929 µM 0.0318602853990667 0.488767244878395 no 1626 0.487291735104585 2337 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1634 st006576 41 µM 0.0317932399293769 0.488794885823586 no 1627 0.487318468833849 2345 3915356
SGTC_1980 st071811 45.7 µM 0.0315787432357372 0.488883317086344 no 1628 0.487403997687433 2316 4974850
SGTC_361 000s-0510 1.45 µM 0.031267193510633 0.489011761696225 no 1629 0.487528226697535 2307 660
SGTC_674 0498-0004 451 µM 0.0311565731004733 0.489057368159372 no 1630 0.487572336365552 2327 4231473
SGTC_2348 9022543 33.42 µM 0.0310304784900219 0.489109354483557 no 1631 0.487622616525469 2316 3162678 YDL140C RPO21
SGTC_195 4234-0266 16.654 µM 0.0309403958782633 0.489146493883373 no 1632 0.487658537040282 2326 2303354
SGTC_1488 4013-0813 75.9 µM 0.0299864156823204 0.489539808040295 no 1633 0.488038943507501 2332 2910057
SGTC_2394 5221648 200 µM 0.0281622484090716 0.490291917492718 no 1634 0.488766373339203 2318 788586
SGTC_431 k089-0097 107 µM 0.0274486791140547 0.490586133720995 no 1635 0.489050936269647 2364 5499420
SGTC_2838 9002687 71.43 µM 0.0274075454223797 0.490603093968887 no 1636 0.489067340066944 2344 6457060
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.0260191548424221 0.491175565081076 no 1637 0.489621030133829 2348 6708514
SGTC_1723 st034307 2.5525 µM 0.0259697920813771 0.491195919028591 no 1638 0.489640716374041 2353 867466
SGTC_1012 4112-3522 18 µM 0.025716513526476 0.491300354762056 no 1639 0.489741726161777 2363 3112398
SGTC_979 1426-2828 121 µM 0.0256255671500034 0.491337855325371 no 1640 0.489777996563481 2324 747872
SGTC_3169 9102970 49.47 µM 0.0256025554914062 0.491347343897634 no 1641 0.489787173876017 2358 17027839
SGTC_706 4262-0057 46.9 µM 0.024796217395215 0.49167983047272 no 1642 0.490108754106783 2365 883298
SGTC_3231 9132313 49.47 µM 0.0232978550813662 0.492297682455191 no 1643 0.490706341323894 2313 4905967
SGTC_384 k007-0144 5.16 µM 0.0230540286011234 0.492398226463104 no 1644 0.490803587895449 2333 6824886
SGTC_628 1636-0253 16 µM 0.0226305683647524 0.492572845184818 no 1645 0.490972480019324 2354 4456143
SGTC_154 3389-1638 511.116 µM 0.0221884665306814 0.492755152502864 no 1646 0.491148808851206 2298 5238686
SGTC_2824 7998404 51.95 µM 0.0219335374688154 0.492860277013039 no 1647 0.491250486086666 2347 837851
SGTC_1253 0550-0034 176 µM 0.0214425561456646 0.493062743241417 no 1648 0.491446313232234 2332 5969915
SGTC_1144 3486-0183 12.5 µM 0.0211786335234012 0.493171577894861 no 1649 0.491551579219166 2329 6744069
SGTC_269 exalamide 29 µM 0.0194083651841196 0.493901602104819 no 1650 0.492257668607186 2350 3316 A derivative of salicylamide.
SGTC_1297 1068-0111 14.1 µM 0.0194005872155746 0.493904809634527 no 1651 0.492260770983565 2359 767057
SGTC_308 4092-1169 104 µM 0.0191317865560703 0.494015659655109 no 1652 0.492367987030926 2366 2268590 YDL196W YDL196W
SGTC_2910 7948405 25.97 µM 0.019026121822764 0.494059234592841 no 1653 0.492410133489079 2357 2971328
SGTC_2493 resveratrol 26.09 µM 0.0185539276342215 0.494253962980151 no 1654 0.492598478461752 2368 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1456 k015-0012 13 µM 0.0184926324201195 0.494279240644209 no 1655 0.492622927519499 2374 2989616
SGTC_2977 9011197 71.43 µM 0.0177228250918646 0.494596705052444 no 1656 0.49292998585814 2365 2704722
SGTC_662 k832-1615 104 µM 0.0156548142938021 0.495449557985108 no 1657 0.493754887772362 2358 5878478
SGTC_839 0122-0028 230 µM 0.0149170807068668 0.495753806435196 no 1658 0.49404916650257 2373 759448
SGTC_1672 st016598 6.51 µM 0.0148160024212082 0.495795492291915 no 1659 0.494089486448449 2333 4665860 YNL267W PIK1
SGTC_2338 7999974 200 µM 0.0144515559778347 0.495945794607777 no 1660 0.494234863975898 2373 315925
SGTC_1718 roemerine 11.9335 µM 0.0138313369725653 0.496201582069934 no 1661 0.494482270816734 2375 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2874 9043904 71.43 µM 0.0124574441439979 0.496768201138146 no 1662 0.495030327364408 2329 4463428
SGTC_627 1391-0720 175 µM 0.0123157142383865 0.496826653589299 no 1663 0.495086865078724 2357 997839
SGTC_1036 k216-0215 33.5 µM 0.0123147215774422 0.496827062984193 no 1664 0.495087261063115 2383 622330
SGTC_695 3505-6186 243 µM 0.0120467178639848 0.49693759364655 no 1665 0.495194171143983 2377 1819379
SGTC_3288 9119690 36.221 µM 0.0118604641419652 0.497014408942277 no 1666 0.495268470320039 2376 17595618 YKL019W RAM2
SGTC_2045 5106652 78.05 µM 0.0116919969044814 0.497083888780315 no 1667 0.495335674363778 2379 673349
SGTC_1956 st077085 54 µM 0.0113517977856602 0.497224195139529 no 1668 0.495471385166993 2382 24208685
SGTC_1128 3448-9350 235 µM 0.00981530478888865 0.49785788610261 no 1669 0.496084322797646 2354 619386
SGTC_445 e6 berbamine 66 µM 0.00923066410465905 0.498099009123292 no 1670 0.496317550106497 2378 6610268 A calcium/calmodulin antagonist.
SGTC_2919 7978188 46.38 µM 0.00880469400730849 0.49827469216755 no 1671 0.496487480677839 2391 2980291
SGTC_2014 4013930 200 µM 0.00724324894699227 0.498918682278208 no 1672 0.497110387014685 2396 64556
SGTC_1818 st052136 56.3 µM 0.00654035260554233 0.499208580332919 no 1673 0.49739079541891 2390 674169
SGTC_3008 9078912 71.4286 µM 0.00652139054063228 0.499216400931717 no 1674 0.497398360027001 2390 16648731
SGTC_1106 tegaserod maleate 11.7 µM 0.0058901569995706 0.499476743210097 no 1675 0.497650180922094 2368 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2261 9010538 184.68 µM 0.00555835903690337 0.499613588122131 no 1676 0.4977825469887 2375 6457250
SGTC_901 1112-0062 60.1 µM 0.00521766510533851 0.499754102085415 no 1677 0.49791846222915 2397 1908457
SGTC_2245 6637752 200 µM 0.00501908249225101 0.499836004439974 no 1678 0.497997684191808 2391 681890
SGTC_2460 5552655 174.22 µM 0.00422382663953839 0.499836004439974 no 1679 0.498314941978843 2378 5401989
SGTC_1859 st055998 20 µM 0.00301855062910459 0.499338907057445 no 1680 0.498795774357265 2401 676301
SGTC_2246 7293507 91.5585 µM 0.00214748056660604 0.49897964832524 no 1681 0.499143279864126 2398 887656
SGTC_797 k781-0471 270 µM 0.00208470863261577 0.498953759086722 no 1682 0.499168322186545 2391 23738129
SGTC_2846 9008642 19.48 µM 0.00100147805842889 0.498506999468012 no 1683 0.499600468126384 2403 2992898
SGTC_2170 morpholine 200 µM 0.000487789929253793 0.498295138349599 no 1684 0.499805399980984 2403 121171 Reacts with secondary amines.
SGTC_2752 diclazuril 33.15 µM 0 0.498093958906378 no 1685 0.5 2405 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1340 1486-1359 257 µM -0.000137221004753266 0.498037364864261 no 1686 0.499945256739617 2407 4309068
SGTC_92 0063-0024 660.874 µM -0.00126742567662288 0.497571236297286 no 1687 0.4994943704457 2405 3594437
SGTC_2349 9023730 187.07 µM -0.00133927977912202 0.497541601726174 no 1688 0.499465704830546 2410 4126287
SGTC_869 0564-0080 44.1 µM -0.00150187763281716 0.497474542033358 no 1689 0.499400837737529 2409 6843321
SGTC_2376 9072922 81.32 µM -0.00260835539475984 0.497018203077018 no 1690 0.498959417930654 2428 17087968
SGTC_2988 9073640 71.4286 µM -0.00389185140487417 0.496488862318954 no 1691 0.498447379845019 2418 9102229
SGTC_2681 menadione 3.18 µM -0.00418180875592067 0.496369278629689 no 1692 0.498331704541105 2415 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3110 9122132 49.47 µM -0.00493460299866157 0.496058814131591 no 1693 0.498031386216233 2442 918317
SGTC_3017 9080681 49.47 µM -0.00493684491192768 0.49605788953384 no 1694 0.498030491833136 2421 16451914
SGTC_2894 9048625 32.47 µM -0.00544089712018969 0.495850011593756 no 1695 0.497829406804923 2414 4092861
SGTC_1861 st057647 17.4 µM -0.00576413798386338 0.495716703284296 no 1696 0.49770045438202 2421 688668
SGTC_499 genistein 192 µM -0.0060689705784098 0.495590987198099 no 1697 0.49757884590059 2416 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2985 9022375 71.43 µM -0.00654284406345863 0.495395557790153 no 1698 0.497389801492274 2473 4939335
SGTC_2140 5586273 200 µM -0.0066610936071074 0.495346790854963 no 1699 0.49734262777777 2414 854421
SGTC_649 1123-0311 367 µM -0.00706737958399418 0.495179236223479 no 1700 0.497180546943257 2420 693629 YIL048W NEO1
SGTC_263 alizarin 107.927 µM -0.00729266392302257 0.495086328054343 no 1701 0.497090673812128 2422 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1306 1185-0270 9.02 µM -0.00741706356359903 0.495035025255233 no 1702 0.497041046878145 2420 1548076
SGTC_2882 9058044 58.44 µM -0.00778682712150284 0.494882534100718 no 1703 0.496893536824319 2430 18076804
SGTC_49 0717-0965 32.132 µM -0.00792131601214517 0.494827070825265 no 1704 0.496839885174453 2487 5889349 YGL099W LSG1
SGTC_655 k060-0012 42 µM -0.00846385902648231 0.494603326882762 no 1705 0.496623449093306 2418 5994525
SGTC_1820 st053765 18.6 µM -0.0091292019770915 0.494328942751657 no 1706 0.496358025933517 2429 3690829
SGTC_2046 4110841 106 µM -0.00952633133402699 0.494165169845907 no 1707 0.49619960113549 2423 44119630 YMR134W ERG29
SGTC_1205 4161-2785 76 µM -0.0101181042146109 0.493921129372485 no 1708 0.495963529304377 2457 3498106
SGTC_2222 6885208 172.143 µM -0.0109504342564275 0.493577889705276 no 1709 0.495631496092544 2424 609514
SGTC_1119 parthenolide 318.541 nM -0.0110330257282168 0.493543830551457 no 1710 0.495598548852828 2463 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3350 9150499 3.57 µM -0.0118213254747922 0.493218753116759 no 1711 0.495284083294611 2434 4910996 YPR165W RHO1
SGTC_3164 9100705 49.47 µM -0.0125642772916872 0.492912380286879 no 1712 0.494987710440232 2453 17174235
SGTC_2232 chlorophetanol 41.5365 µM -0.0125715671441377 0.492909374173286 no 1713 0.494984802439544 2424 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_276 colchicine 750 µM -0.0126796512574802 0.49286480361724 no 1714 0.494941686553516 2462 2833 A microtubule depolymerizer.
SGTC_973 1325-0077 65.9 µM -0.013538324339682 0.492510716522226 no 1715 0.494599154999033 2445 2835149
SGTC_2863 9028737 58.44 µM -0.0141318917012698 0.492265953294497 no 1716 0.494362378547505 2427 6460917
SGTC_2067 5224629 34.075 µM -0.0145290371683262 0.492102188150158 no 1717 0.494203956698033 2449 2835000
SGTC_2986 9022445 71.43 µM -0.0159106076013965 0.491532500438455 no 1718 0.493652853716022 2422 6459286
SGTC_2341 7987486 176.74 µM -0.0167723517750076 0.491177170682515 no 1719 0.49330911344086 2445 1258686
SGTC_707 0865-0008 204 µM -0.016828621703844 0.491153968700444 no 1720 0.493286668155021 2437 723043
SGTC_1728 st035614 33.7865 µM -0.0170572249286692 0.491059708219452 no 1721 0.493195481752445 2515 15945546
SGTC_1241 0364-0022 50.8 µM -0.0189601444913474 0.490275092997308 no 1722 0.492436449889019 2458 4563895
SGTC_665 3914-0008 307 µM -0.0192542932976104 0.49015381231321 no 1723 0.492319122913056 2451 1069549
SGTC_2525 harmine 47.85 µM -0.0198055277165092 0.489926534954577 no 1724 0.492099254134616 2464 5280953 A monoamine oxidase inhibitor
SGTC_1319 1306-0155 43.7 µM -0.0205969991096199 0.489600212144637 no 1725 0.491783567161499 2450 3122360
SGTC_3200 9114385 49.47 µM -0.0216147418109083 0.489180608177524 no 1726 0.49137763700734 2466 17018030 YLR208W SEC13
SGTC_383 2324-0395 7.37 µM -0.0228959304236047 0.48865240548104 no 1727 0.490866643298766 2475 3146421
SGTC_2435 5706476 10.6 µM -0.0233758104234184 0.488454567780145 no 1728 0.490675250109385 2458 5725375
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.0240927775389236 0.488158992680698 no 1729 0.490389302170445 2475 6708739 YPR165W RHO1
SGTC_619 1652-1634 108 µM -0.0245716640971176 0.487961571698872 no 1730 0.490198310623998 2459 5400454
SGTC_1390 3413-2614 145 µM -0.0261375323351314 0.487316063370753 no 1731 0.489573820402894 2458 3421432
SGTC_2216 7189485 200 µM -0.026381067569777 0.487215672156567 no 1732 0.489476697392665 2458 731273
SGTC_3144 9087057 49.47 µM -0.027081395371845 0.486926984346478 no 1733 0.489197406830569 2444 17249618
SGTC_2926 9010726 65.15 µM -0.0279209745487395 0.486580903638568 no 1734 0.488862589846517 2490 2994293
SGTC_1714 st033236 13.627 µM -0.0281109978208246 0.486502576042235 no 1735 0.488786811274101 2470 2916566
SGTC_1310 1188-0297 994 nM -0.0287356062989728 0.486245116100716 no 1736 0.488537729182573 2470 1588352
SGTC_2832 7992762 51.95 µM -0.0294183292073051 0.485963708294694 no 1737 0.488265477268676 2473 2985177
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.0294466020373948 0.485952054821891 no 1738 0.488254202925737 2500 688761
SGTC_516 3992-2719 87.3 µM -0.0300795236119989 0.485691180865415 no 1739 0.488001815565818 2459 5350887 YDR037W KRS1
SGTC_675 1309-0189 238 µM -0.0304602200871847 0.485534270534857 no 1740 0.487850009210152 2488 4246530
SGTC_1974 st069448 26.9 µM -0.031709233109627 0.485019485077478 no 1741 0.487351965816982 2467 6323587 YNR016C ACC1
SGTC_203 k066-0004 30.888 µM -0.0318712148601024 0.484952725494896 no 1742 0.487287377093656 2448 6795412
SGTC_1365 1672-3266 55.4 µM -0.0320849934884449 0.484864618857446 no 1743 0.487202135355535 2457 6415873
SGTC_2821 7996764 71.43 µM -0.0324268803668467 0.48472371527522 no 1744 0.487065813161643 2490 2987135
SGTC_3157 9099274 49.47 µM -0.03248393258081 0.484700202240651 no 1745 0.487043064605596 2467 17217662
SGTC_2450 5739737 12.93 µM -0.0328157829077907 0.484563437208261 no 1746 0.486910746025482 2494 2262825
SGTC_685 1278-0033 54.9 µM -0.032831736220381 0.484556862436454 no 1747 0.486904385002181 2454 3590572
SGTC_2792 7535235 81.82 µM -0.0332230279855486 0.484395602321221 no 1748 0.486748367289968 2508 1281891
SGTC_1284 0929-0043 16 µM -0.0339774462023098 0.484084696875367 no 1749 0.486447567818942 2512 1239883
SGTC_2586 curcumin 80 µM -0.0340117115741283 0.484070575903424 no 1750 0.486433905809775 2486 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2324 6149169 200 µM -0.0340194741344692 0.484067376907007 no 1751 0.486430810787333 2485 2888231
SGTC_3230 9131665 49.47 µM -0.0358724623105999 0.483303779473343 no 1752 0.485692026811314 2470 15943720
SGTC_1514 1189-1591 158 µM -0.036331306994807 0.483114703632952 no 1753 0.485509093519796 2473 767698 YMR146C TIF34
SGTC_2161 5662504 8.5105 µM -0.0392162246358347 0.481926006141707 no 1754 0.484358999098977 2504 2859334
SGTC_1915 st067105 30.6 µM -0.0399028599499926 0.481643109147833 no 1755 0.484085285505186 2464 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1526 st051518 75 µM -0.0400921799559596 0.481565110030438 no 1756 0.484009818140947 2545 673993
SGTC_1590 st077108 57.8 µM -0.0401828625804934 0.48152774938621 no 1757 0.483973670137255 2457 5489485
SGTC_2060 5238662 140 µM -0.0431415356241095 0.480308886464477 no 1758 0.482794354732072 2525 790130
SGTC_3149 9097855 49.47 µM -0.0437091856403809 0.480075056529893 no 1759 0.482568108566951 2512 25236625 YMR079W SEC14
SGTC_1840 st055363 71 µM -0.0439980358830507 0.479956074163669 no 1760 0.482452984745651 2533 676033
SGTC_416 estradiol valerate 100 µM -0.0440858596512576 0.479919898401686 no 1761 0.482417982094968 2512 13791 A steroid.
SGTC_2516 gossypol 71.55 µM -0.0441517203485938 0.479892769625159 no 1762 0.482391733037095 2513 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2762 leflunomide 42.06 µM -0.0446988703354699 0.479667395883591 no 1763 0.48217366707078 2490 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1509 1326-1131 80 µM -0.0452197747966266 0.479452838840568 no 1764 0.481966066181644 2470 768313
SGTC_17 0960-0276 49.807 µM -0.0454780002494536 0.479346479717138 no 1765 0.481863155004874 2489 6821114
SGTC_2193 5925765 200 µM -0.0455418386133183 0.47932018589568 no 1766 0.481837713542645 2502 877370
SGTC_3114 9122766 49.47 µM -0.0456628105926934 0.479270360059456 no 1767 0.481789502860222 2540 17176985
SGTC_2328 6201408 200 µM -0.0469891676143771 0.478724082670586 no 1768 0.481260930492342 2526 2890418
SGTC_1872 amphotericin b 148 nM -0.0476278719153088 0.478461038191135 no 1769 0.481006409327177 2506 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_770 0389-1121 67.2 µM -0.0478474785601082 0.478370597380262 no 1770 0.480918898721846 2641 6753108
SGTC_2342 7990637 118.86 µM -0.0479347487733884 0.478334657115317 no 1771 0.480884122847092 2535 2033102 YER133W GLC7
SGTC_966 1300-0360 30.2 µM -0.0482333225971405 0.478211697568336 no 1772 0.480765146745754 2515 70588
SGTC_330 1488-0319 80.1 µM -0.0483283341235786 0.478172570077536 no 1773 0.480727286782985 2545 6846614
SGTC_3043 9092303 49.47 µM -0.0484782402036588 0.478110836429771 no 1774 0.480667552925186 2513 25236084
SGTC_1911 st060208 74.3 µM -0.0488405299634221 0.477961642061448 no 1775 0.480523191229427 2553 688783
SGTC_1870 st057514 26.5 µM -0.0491250901929556 0.477844459617393 no 1776 0.480409804230155 2491 5393161
SGTC_1293 1000-1278 195 µM -0.0496791449146794 0.477616304333295 no 1777 0.480189037940967 2527 678847
SGTC_1199 1638-0010 4.46 µM -0.0523677412886652 0.476509267477091 no 1778 0.479117838778113 2494 3111136
SGTC_2644 guaiazulene 100 µM -0.0528404108566463 0.476314662993042 no 1779 0.478929531625585 2529 3515 A coloring agent.
SGTC_2999 9069765 71.4286 µM -0.0532118464968754 0.476161741854131 no 1780 0.47878155842473 2544 2097066
SGTC_183 3914-0051 30.55 µM -0.0532647044512841 0.476139980364618 no 1781 0.478760501014674 2526 1596232
SGTC_3226 9131256 49.47 µM -0.0536400649882057 0.47598544740782 no 1782 0.478610967599892 2484 17178073
SGTC_1678 st019265 80.2 µM -0.0548792085788224 0.475475327586145 no 1783 0.478117348031432 2510 5367020
SGTC_1784 st039334 36.3 µM -0.0560273944549322 0.475002688303525 no 1784 0.477659991906391 2624 3496984
SGTC_1246 0422-0085 105 µM -0.0567021481447748 0.474724949033306 no 1785 0.477391231399388 2524 264295
SGTC_299 1273-0059 1.44 µM -0.0569800534619841 0.474610562381254 no 1786 0.47728054217677 2527 2848077
SGTC_3060 1327-0027 12.5 µM -0.0572039173695502 0.474518420855102 no 1787 0.477191378831379 2540 16000455 YPR107C YTH1
SGTC_2544 sphondin 68.51 µM -0.0574285842447913 0.474425950200873 no 1788 0.477101896817842 2576 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_465 cgp-37157 41 µM -0.0575732600068072 0.474366403823254 no 1789 0.477044274877584 2497 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2166 5933061 31.504 µM -0.0589915359279339 0.473782693217458 no 1790 0.476479424861759 2703 2877375
SGTC_2154 5570129 200 µM -0.0595317022499424 0.473560395206116 no 1791 0.476264307751053 2501 673366
SGTC_471 1-acyl-paf 4 µM -0.0605937594778509 0.473123344251714 no 1792 0.475841371804321 2505 16759367
SGTC_2719 novobiocin 32.65 µM -0.060881491971248 0.47300494397581 no 1793 0.475726794683575 2522 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1435 4092-0789 56.7 µM -0.0613155019426681 0.472826355869326 no 1794 0.475553972633079 2503 2248285
SGTC_342 k048-0088 23.3 µM -0.0616157369325596 0.472702817205206 no 1795 0.475434422247453 2504 6820570
SGTC_900 1112-0045 141 µM -0.0616800148157845 0.472676368917168 no 1796 0.475408827763796 2520 56211 YIL048W NEO1
SGTC_2611 pyromycin 23.93 µM -0.0638991987292656 0.471763320562213 no 1797 0.474525245149125 2549 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2352 9027995 87.8 µM -0.0641724758869149 0.47165089513333 no 1798 0.474416446634809 2566 2997347
SGTC_2692 st077426 47.7 µM -0.0643897178798876 0.471561524019633 no 1799 0.474329958490692 2530 25238571
SGTC_691 1548-0686 185 µM -0.0649681961375152 0.471323551030759 no 1800 0.474099661271727 2543 46495133
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.0651055453212 0.471267050156125 no 1801 0.474044982637284 2544 551469
SGTC_1171 0368-0077 21.4 µM -0.0651323847224568 0.471256009388846 no 1802 0.474034297943488 2535 3239779
SGTC_3009 9080819 71.4286 µM -0.0654652882713864 0.471119066645017 no 1803 0.473901771486835 2578 17027216
SGTC_2879 9041815 71.43 µM -0.0669600933912056 0.470504208000375 no 1804 0.473306736362333 2516 4942971
SGTC_2184 6075246 200 µM -0.0679055929496469 0.470115331589212 no 1805 0.472930393251299 2568 2267320
SGTC_2075 5212009 200 µM -0.068074832509351 0.470045727707593 no 1806 0.472863032309236 2548 780898
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.069377137724814 0.469510153817337 no 1807 0.472344713257978 2525 688664
SGTC_2270 7924575 90.91 µM -0.0695831483752131 0.469425436827873 no 1808 0.472262725037166 2647 1262135
SGTC_1763 st044482 94.5 µM -0.0703923604003509 0.469092681025128 no 1809 0.47194068584193 2630 88505
SGTC_895 0964-0006 13.7 µM -0.07163109654633 0.46858334265006 no 1810 0.471447746083806 2512 6738897
SGTC_3280 9140961 49.47 µM -0.0728397260251955 0.46808643296048 no 1811 0.470966829052339 2535 4901226
SGTC_1765 st044815 90.4 µM -0.0733998158776665 0.467856177319528 no 1812 0.470743982055078 2598 645695
SGTC_898 1000-0849 28.3 µM -0.0744192105128519 0.467437126917655 no 1813 0.470338411703938 2505 6751807
SGTC_2400 5203494 178.7 µM -0.0775790942550291 0.466138400524474 no 1814 0.46908143631017 2542 6777674
SGTC_1737 st035557 69.7 µM -0.0785824236154708 0.465726102405594 no 1815 0.468682384111518 2528 5716916
SGTC_750 4073-0104 132 µM -0.0803464036537495 0.46500131957238 no 1816 0.467980876351316 2563 22330957
SGTC_2839 9003951 25.97 µM -0.0803473956566963 0.46500091201137 no 1817 0.467980481874751 2525 2990634
SGTC_349 k015-0014 24 µM -0.0819553507618778 0.464340337733367 no 1818 0.46734110944499 2540 2196908
SGTC_2621 lithochol-11-enic acid 100 µM -0.0822050666014357 0.464237759149532 no 1819 0.467241822259577 2537 6708711
SGTC_1625 st003711 30.1 µM -0.0825393395084056 0.464100449830041 no 1820 0.467108918318686 2622 24207034 YER133W GLC7
SGTC_1363 1636-0063 10.4 µM -0.0828385383068975 0.463977551531815 no 1821 0.466989962641497 2559 6072185
SGTC_811 0416-0114 265 µM -0.0847330490917081 0.463199446349489 no 1822 0.466236810532168 2630 6612453
SGTC_467 ro 31-8220 72.8 µM -0.0848381132883042 0.463156298934734 no 1823 0.466195046364944 2628 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_534 k292-0788 63.4 µM -0.0874185544563858 0.46209670923573 no 1824 0.465169410756548 2542 4146317
SGTC_1631 benzylvanillin 81.9 µM -0.0882761291830857 0.461744628099573 no 1825 0.464828605513714 2681 75506
SGTC_1927 st060202 13.8 µM -0.0906363698599017 0.460775776356588 no 1826 0.463890765943237 2545 688887
SGTC_1768 st044301 37.178 µM -0.0908987377071191 0.460668091634766 no 1827 0.463786526602781 2598 3931349
SGTC_2598 perillyl alcohol 100 µM -0.0913441729399738 0.460485276417342 no 1828 0.463609559871803 2671 10819 An apoptosis inducer.
SGTC_948 3448-0295 75.3 µM -0.0915324141666075 0.460408021092842 no 1829 0.46353477577556 2568 678569
SGTC_1670 st016595 4.04 µM -0.0916404618346712 0.460363678358997 no 1830 0.463491851397006 2556 597879
SGTC_65 0798-0905 34.986 µM -0.0918380371576071 0.460282594774907 no 1831 0.4634133612333 2733 3602145
SGTC_1907 st060210 83.7 µM -0.0923214572580079 0.46008420938708 no 1832 0.463221320372525 2585 688793
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0923930750035088 0.460054819822491 no 1833 0.463192870621201 2617 75037 A free radical scavenger.
SGTC_722 3534-0461 190 µM -0.0932636675051228 0.459697574824755 no 1834 0.462847047685197 2616 658262
SGTC_1680 diphenhydramine 100 µM -0.0938550801893886 0.459454908961241 no 1835 0.462612138538596 2642 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2185 6113692 200 µM -0.0942524318079573 0.459291877862437 no 1836 0.462454317774673 2664 874150
SGTC_1926 methyl fluorone black 53.6 µM -0.0944232620496151 0.459221789292912 no 1837 0.462386468955986 2561 72721 Reacts with homocysteine.
SGTC_217 ketoconazole 989 nM -0.0946736481347624 0.459119062685395 no 1838 0.462287024841172 2575 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1228 0124-0032 52.5 µM -0.0958388484716774 0.458641048663895 no 1839 0.461824281367244 2628 X1228
SGTC_1028 k015-0029 4.8 µM -0.0959294986213271 0.458603862670873 no 1840 0.461788283050972 2572 4588309
SGTC_2794 7785382 27.27 µM -0.0959582671550785 0.458592061480955 no 1841 0.461776858769269 2551 2205081
SGTC_439 amiodarone 34.4 µM -0.0965525135798296 0.458348302806705 no 1842 0.461540884447758 2656 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2690 usnic acid 100 µM -0.0972099416938865 0.45807864538521 no 1843 0.461279836554735 2668 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_911 3456-4043 236 µM -0.0975182344534989 0.457952199519773 no 1844 0.461157427122263 2648 914281
SGTC_2373 9071805 200 µM -0.0990415852166979 0.457327461938644 no 1845 0.460552626086292 2589 10149009
SGTC_2734 clemastine 41.6 µM -0.100351492400528 0.45679034342277 no 1846 0.46003263937412 2573 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_764 1951-2361 146 µM -0.100770143558587 0.45661869496581 no 1847 0.45986646407743 2595 5438930
SGTC_3132 9126706 49.47 µM -0.101368452010006 0.456373400440295 no 1848 0.459628989547203 2798 850858
SGTC_3056 9094900 49.47 µM -0.101532344133474 0.456306210836996 no 1849 0.459563941655001 2636 25236784
SGTC_844 0330-0132 15.3 µM -0.102605018874737 0.455866485492801 no 1850 0.459138229690495 2611 2828079
SGTC_2829 7992743 58.44 µM -0.103450915861562 0.45551976204694 no 1851 0.45880255193341 2652 16462845
SGTC_2062 5245942 200 µM -0.10365700120458 0.455435295156978 no 1852 0.458720775416474 2567 1376160
SGTC_1323 1348-1351 11.2 µM -0.104065829534976 0.455267737252794 no 1853 0.458558553832824 2604 6989654
SGTC_3118 9124250 49.47 µM -0.104353235037041 0.455149949141345 no 1854 0.458444516512302 2662 1504786
SGTC_604 1000-0114 314 µM -0.10447807790595 0.455098785705707 no 1855 0.458394982178103 2634 1572745
SGTC_2753 fluvastatin 17.09 µM -0.1060981002593 0.454434931692548 no 1856 0.457752259206359 2664 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_757 1066-0008 322 µM -0.106452908809414 0.454289554893628 no 1857 0.457611508178641 2756 6842497
SGTC_2034 5197015 53.07 µM -0.106550607831324 0.454249525447142 no 1858 0.457572752329035 2705 780676
SGTC_1432 4049-0298 68.4 µM -0.107103024724327 0.454023196802185 no 1859 0.457353623794779 2655 741646
SGTC_589 1227-0070 34.1 µM -0.108287452438485 0.453537979796819 no 1860 0.456883837794673 2692 2841384
SGTC_1796 st049173 110.4 µM -0.111065209285239 0.452400307019909 no 1861 0.455782318490205 2584 94134
SGTC_1847 st056231 15 µM -0.115414914905959 0.450619606946682 no 1862 0.454058128788198 2596 5393180
SGTC_95 0471-0001 561.058 µM -0.118917338702367 0.449186490862165 no 1863 0.452670422468963 2630 4015405
SGTC_2918 7977171 22.06 µM -0.120525096957956 0.448528851720282 no 1864 0.452033600027112 2602 2236483
SGTC_1010 4112-3296 15.2 µM -0.120813920305401 0.448410726043345 no 1865 0.451919212030935 2677 704384
SGTC_515 4092-1064 102 µM -0.123106467281205 0.447473261802816 no 1866 0.45101139504438 2724 717353
SGTC_3242 9133940 49.47 µM -0.12342065141531 0.447344808924093 no 1867 0.450887002314316 2785 17248444
SGTC_2286 7945697 125 µM -0.123488162292994 0.447317208102469 no 1868 0.450860273833153 2698 1245733
SGTC_2523 spermine 47.74 µM -0.123530655126843 0.447299835668047 no 1869 0.450843450452472 2676 1103 A DNA binding polyamine.
SGTC_2391 6285546 200 µM -0.124403496915349 0.446943012344613 no 1870 0.450497902360221 2608 846083
SGTC_1315 1237-0019 3.69 µM -0.124420100625761 0.446936225056606 no 1871 0.450491329503781 2690 825140
SGTC_683 panaxydol 45 µM -0.12469789887028 0.44682266860792 no 1872 0.450381360438394 2698 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2101 5377231 179.231 µM -0.124756746000706 0.446798614043493 no 1873 0.450358065733292 2725 2844213
SGTC_2132 5317594 122.667 µM -0.125047694612356 0.446679687721748 no 1874 0.450242895901137 2638 794577
SGTC_3152 9099253 49.47 µM -0.125355706521965 0.446553791939392 no 1875 0.450120976256187 2715 25236131
SGTC_1950 st077106 7.18 µM -0.126132054778934 0.446236493815265 no 1876 0.449813697024219 2711 13831864
SGTC_3259 9138485 49.47 µM -0.128388139082399 0.445314614906102 no 1877 0.448920908558348 2798 17646153
SGTC_3224 9130643 49.47 µM -0.128609597937035 0.445224138464273 no 1878 0.448833285665336 2777 17644395
SGTC_1729 st035615 45.989 µM -0.129654524580904 0.444797274956896 no 1879 0.448419881450755 2792 17385451
SGTC_925 2064-1272 59.6 µM -0.130639704170434 0.444394877362507 no 1880 0.448030166241265 2674 6815817
SGTC_40 0327-0103 19.753 µM -0.131500750061731 0.444043229218274 no 1881 0.44768959663199 2689 409036
SGTC_3215 9129942 49.47 µM -0.132437200913566 0.443660835962864 no 1882 0.447319245868696 2690 17682944
SGTC_1562 morin hydrate 59.1 µM -0.1334100381527 0.443263640130327 no 1883 0.446934553537682 2804 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_395 anisomycin 6.25 µM -0.135596777573007 0.442371033684207 no 1884 0.446070026524342 2687 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2584 androsterone 48.74 µM -0.135654355787896 0.442347534731167 no 1885 0.446047266433469 2693 2754130 A steroid.
SGTC_9 0092-0002 10.449 µM -0.135672930908879 0.442339953853486 no 1886 0.446039923912363 2669 759368
SGTC_572 0960-0087 17.7 µM -0.135830039106698 0.442275835706475 no 1887 0.445977821678581 2651 6796365
SGTC_953 1188-0045 9.7 µM -0.136899026770683 0.441839606481984 no 1888 0.445555304059315 2761 6144426
SGTC_181 1447-1644 8.07 µM -0.136934761131026 0.441825025328557 no 1889 0.445541181110508 2671 534600
SGTC_216 k038-0035 28.382 µM -0.13758806178946 0.441558464522116 no 1890 0.445282995550429 2624 4444231 YPR107C YTH1
SGTC_3154 9100113 49.47 µM -0.13797538634802 0.441400440210086 no 1891 0.445129935159865 2668 25237525
SGTC_881 0833-0569 170 µM -0.138591507673336 0.441149088474411 no 1892 0.444886477219951 2664 5418700
SGTC_321 4534-3890 65.3 µM -0.139471654853676 0.440790066370892 no 1893 0.444538726573859 2766 699746
SGTC_386 1509-0011 3.07 µM -0.139523807568735 0.440768794206063 no 1894 0.44451812210678 2651 3107280
SGTC_218 alverine citrate 93.75 µM -0.140657254464139 0.44030652370277 no 1895 0.444070357638097 2752 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_502 l-744,832 89.3 µM -0.141053016006735 0.440145133516677 no 1896 0.443914030126387 2757 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1054 3429-0080 167 µM -0.141604165891449 0.439920393076062 no 1897 0.443696338094915 2755 1162877
SGTC_766 1391-0721 126 µM -0.142333213322369 0.439623141731369 no 1898 0.443408406572186 2836 1020919 YIL115C NUP159
SGTC_929 2805-0021 398 µM -0.14278043448789 0.439440815018982 no 1899 0.44323179488156 2766 3098024
SGTC_3293 9120939 62.045 µM -0.144560400140213 0.438715272022226 no 1900 0.442528982418386 2796 934087
SGTC_1404 3909-7820 48.3 µM -0.144982106872202 0.438543407565809 no 1901 0.442362499580862 2688 23741373
SGTC_1635 st007035 42.4 µM -0.14512048508124 0.438487014746672 no 1902 0.442307872370963 2640 3716403
SGTC_879 0831-1030 162 µM -0.14535367157633 0.43839198784274 no 1903 0.442215820420038 2676 1549252
SGTC_878 0828-0289 13.7 µM -0.145510893830769 0.438327919481181 no 1904 0.442153757629137 2677 745350 YLR208W SEC13
SGTC_160 3453-0671 289.699 µM -0.146535112089117 0.43791058826791 no 1905 0.44174948681269 2687 5322268
SGTC_2208 7283366 200 µM -0.147027588180065 0.437709946955376 no 1906 0.441555122366045 2676 898663
SGTC_1826 st055655 41.6 µM -0.147195490189859 0.437641545100586 no 1907 0.441488860066751 2709 676168
SGTC_1382 3002-2117 298 µM -0.147686624664886 0.437441471786096 no 1908 0.44129504392351 2736 1497314
SGTC_3127 9126946 49.47 µM -0.147821121611565 0.437386684590093 no 1909 0.441241969913219 2768 27243249
SGTC_3084 9116877 49.47 µM -0.148371113916957 0.437162658281104 no 1910 0.441024947743624 2649 27241325
SGTC_1794 st048918 76.9 µM -0.148759042688882 0.437004656817323 no 1911 0.440871885078322 2629 672303
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.148871862241482 0.436958707858243 no 1912 0.440827372219509 2652 6312947
SGTC_3126 9127922 49.47 µM -0.149064684260771 0.436880177597214 no 1913 0.440751296186414 2927 45595682
SGTC_2920 7982904 15.77 µM -0.14988294329377 0.436546954489173 no 1914 0.440428484486201 2774 6456808
SGTC_182 3448-4371 550.524 µM -0.14995049727114 0.436519446204235 no 1915 0.440401835505609 2649 3491403
SGTC_2915 7971052 15.16 µM -0.14996525337762 0.436513437491826 no 1916 0.440396014489822 2650 5741558
SGTC_2172 5754775 163.918 µM -0.150235405886003 0.436403433507673 no 1917 0.440289446513727 2688 2263357
SGTC_1395 3486-0190 4.35 µM -0.150604182012753 0.436253278700249 no 1918 0.440143981127727 2725 6748079
SGTC_1663 st014140 55.4 µM -0.150895290411177 0.436134754397534 no 1919 0.44002915782797 2676 4207120
SGTC_7 0192-1582 4.227 µM -0.15132760427941 0.435958749106633 no 1920 0.439858647478481 2684 252616
SGTC_3292 9120825 59.784 µM -0.152388632703529 0.435526832946723 no 1921 0.439440211079306 2700 24824900
SGTC_3187 9109394 49.47 µM -0.153675221630128 0.435003200370145 no 1922 0.438932911474126 2712 17098090
SGTC_794 k038-0031 316 µM -0.154088441376472 0.434835046997914 no 1923 0.438770000940648 2679 6624242
SGTC_1143 3454-2408 5.08 µM -0.154918444671643 0.434497325662091 no 1924 0.438442806225552 2654 X1143
SGTC_1748 st037455 53.6035 µM -0.154939798621217 0.434488637549814 no 1925 0.438434388861976 2844 580690
SGTC_2856 9022925 19.48 µM -0.15498473109011 0.434470356335525 no 1926 0.43841667733824 2823 4944862
SGTC_886 0866-0150 153 µM -0.155518992480649 0.434252997613995 no 1927 0.438206091132134 2862 271463
SGTC_1707 st032323 6.317 µM -0.15578898373193 0.434143162021298 no 1928 0.438099677154434 2686 3132057 YMR211W DML1
SGTC_809 3998-0021 90 µM -0.156527937168314 0.433842573161269 no 1929 0.437808449982488 2681 715485
SGTC_2727 riluzole 51.77 µM -0.15671710550483 0.433765630078882 no 1930 0.43773390271059 2684 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2421 5690543 90.72 µM -0.157383555466527 0.433494575583878 no 1931 0.437471286390989 2763 3397993
SGTC_1731 st035964 63 µM -0.157738693742709 0.433350148659544 no 1932 0.437331354483154 2743 6739575
SGTC_2596 sinensetin 100 µM -0.157827727801781 0.433313941860969 no 1933 0.437296274430152 2748 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_3266 9136860 49.47 µM -0.158096660915676 0.433204580292042 no 1934 0.437190315863412 2687 4871271 YPR165W RHO1
SGTC_3277 9138724 49.47 µM -0.160621704351242 0.432178022725682 no 1935 0.436195679628656 2765 15943418
SGTC_1681 tripelennamine 100 µM -0.160996667352615 0.432025620210342 no 1936 0.436048012734482 2669 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1885 st057546 99.9 µM -0.161161292465085 0.431958712052743 no 1937 0.435983183341879 2848 702008
SGTC_325 2810-4341 181 µM -0.161265247017942 0.431916463078547 no 1938 0.435942246910102 2814 774970
SGTC_2564 betulinic acid 100 µM -0.161910290189612 0.4316543235168 no 1939 0.435688249671883 2918 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1281 0884-0031 11.8 µM -0.161933219212412 0.431645005927832 no 1940 0.435679221448349 2695 1548255
SGTC_3025 9087895 49.47 µM -0.16221013126726 0.431532481123008 no 1941 0.435570190931517 2794 17173641
SGTC_487 nimodipine 119 µM -0.162248346912724 0.431516952411933 no 1942 0.435555144402979 2732 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2025 5147754 141 µM -0.16286967204993 0.431264495327304 no 1943 0.435310525072114 2784 315777 YLR208W SEC13
SGTC_2855 9016525 58.44 µM -0.164106536997464 0.430762015535017 no 1944 0.434823637901555 2681 43811474
SGTC_2993 9054257 71.4286 µM -0.164137929184247 0.430749263827513 no 1945 0.434811281769698 2689 6470217 YGL055W OLE1
SGTC_1640 st009078 66.4 µM -0.166922874435783 0.429618290054763 no 1946 0.433715367230419 2831 690618
SGTC_2079 5212404 121 µM -0.167511470099521 0.429379333367254 no 1947 0.433483811604338 2751 758462
SGTC_2151 5563267 85.4165 µM -0.167697129633671 0.429303965108729 no 1948 0.433410777216278 2744 5310824
SGTC_1068 loratadine 26.9 µM -0.167785923159312 0.429267920397499 no 1949 0.433375848594739 2745 3957 A H1 histamine antagonist.
SGTC_1790 st045711 43.5 µM -0.167826832065552 0.429251314095603 no 1950 0.433359756473754 2803 585119
SGTC_2715 st079500 56.4 µM -0.167946649850355 0.429202676744618 no 1951 0.433312625018585 2685 28246688
SGTC_302 1094-0063 18.9 µM -0.168293788794189 0.429061769521889 no 1952 0.43317607999926 2690 5440289
SGTC_833 3852-0053 558 µM -0.168629283387168 0.428925597449036 no 1953 0.433044122795294 2865 3123681
SGTC_2051 5263410 176 µM -0.168894362086146 0.428818012081308 no 1954 0.43293986694816 2695 227584
SGTC_2812 7970281 58.44 µM -0.169169577601128 0.428706318161295 no 1955 0.432831629214895 2831 2233435
SGTC_678 1218-2179 85.9 µM -0.170102236955847 0.428327848657091 no 1956 0.432464867159349 2692 6820081 YOR116C RPO31
SGTC_33 0986-0033 35.816 µM -0.170446045026261 0.428188349300728 no 1957 0.432329681594737 2701 2848082
SGTC_1470 k295-0292 231 µM -0.170632196595654 0.428112822461002 no 1958 0.432256489977146 2803 5045612
SGTC_3332 9141069 11.198 µM -0.171688206173963 0.427684420093422 no 1959 0.431841329121534 2700 17332883
SGTC_3117 9124945 49.47 µM -0.17171880058329 0.427672009809969 no 1960 0.431829302318915 2688 17592065
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.172183103254107 0.427483679361974 no 1961 0.431646790571471 2851 61125 An anti-inflammatory.
SGTC_582 0987-0078 156 µM -0.172582430580819 0.427321717427631 no 1962 0.431489831512657 2722 1625765
SGTC_2779 methotrexate 400 µM -0.174014069496475 0.426741164293725 no 1963 0.430927202533496 2724 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1252 0493-0875 34.8 µM -0.174133225726776 0.426692851617381 no 1964 0.430880380862999 2698 3960963
SGTC_64 000l-0018 272.079 µM -0.174491710947098 0.426547508064461 no 1965 0.430739522273461 2695 6811119
SGTC_2984 9022109 38.96 µM -0.175457082923151 0.426156159170106 no 1966 0.430360245237429 2733 6459207
SGTC_1346 1488-2224 62.4 µM -0.176558847614364 0.425709607354088 no 1967 0.429927460503575 2721 3722427
SGTC_2390 9097792 176.6 µM -0.176852116268895 0.425590759845194 no 1968 0.429812275662901 2733 4497149
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.178264565019254 0.425018457996285 no 1969 0.429257603033069 2964 6710655
SGTC_466 geldanamycin 89.2 µM -0.178750386254434 0.424821647386409 no 1970 0.429066851878061 2768 5288382 HSP90 inhibitor.
SGTC_805 3852-0218 479 µM -0.180004932235645 0.424313506163518 no 1971 0.428574348042186 2727 6615355
SGTC_1881 5652484 16 µM -0.180089500567625 0.424279257127657 no 1972 0.428541152591583 2832 2255129
SGTC_1902 st060212 70.5 µM -0.180361634410642 0.424169050466808 no 1973 0.428434335830691 2724 688944
SGTC_3096 9117468 49.47 µM -0.180462929255719 0.42412803037701 no 1974 0.42839457736893 2847 41316311
SGTC_2157 5649910 96.377 µM -0.180568388889239 0.424085324598945 no 1975 0.428353184990259 2746 2858091
SGTC_2834 9001755 58.44 µM -0.180951767385736 0.423930083356316 no 1976 0.428202717492273 2838 2989575
SGTC_1853 st056710 91.2 µM -0.18104813456078 0.423891063304912 no 1977 0.428164897168992 2902 269167
SGTC_3012 9080433 71.4286 µM -0.181411188684382 0.42374406569388 no 1978 0.428022418643458 2765 17688859
SGTC_2711 st079103 59.1 µM -0.181433600703201 0.423734991600403 no 1979 0.428013623481494 2811 54693780
SGTC_1423 4048-0112 5.59 µM -0.182011048239531 0.423501210781537 no 1980 0.427787027742611 2813 X1423
SGTC_3177 9107506 49.47 µM -0.182783478933018 0.423188532745011 no 1981 0.427483956061317 2819 8897194
SGTC_701 4424-0219 185 µM -0.184416550787478 0.42252762876885 no 1982 0.426843343420216 2854 2911779
SGTC_1771 st048882 4.1505 µM -0.184747632477202 0.422393666573165 no 1983 0.426713491940999 2732 4580403
SGTC_1450 4112-4260 37.6 µM -0.185168123207279 0.422223540654339 no 1984 0.426548585352124 2771 1633175
SGTC_971 1315-0384 26.7 µM -0.185822310116709 0.421958892693765 no 1985 0.426292054146455 2769 6769120
SGTC_3089 9117425 49.47 µM -0.185943233304667 0.421909977693189 no 1986 0.426244639043886 2807 9401657
SGTC_1093 fluphenazine 7.97 µM -0.186898124913232 0.421523754008442 no 1987 0.425870254698768 2749 6602611 An atypical antipsychotic.
SGTC_2374 9071832 200 µM -0.187382293524368 0.42132795181875 no 1988 0.425680452220266 2728 17381698
SGTC_2244 6635614 200 µM -0.188192944747646 0.421000160667635 no 1989 0.425362701476932 2701 836499
SGTC_1691 st019933 84.6 µM -0.188476039103189 0.420885702841453 no 1990 0.425251748467078 2720 6176082
SGTC_509 pifithrin 175 µM -0.189086391056155 0.420638954319637 no 1991 0.425012553724869 2742 4817 A p53 inhibitor.
SGTC_1420 4'-methoxyflavone 42 µM -0.18987369934914 0.420320713272792 no 1992 0.424704051208002 2753 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1174 0739-0097 51.1 µM -0.190781190559912 0.419953957229756 no 1993 0.424348512883988 2808 728447
SGTC_3045 9092950 49.47 µM -0.190896870065709 0.419907211177848 no 1994 0.42430319620362 2784 44120432
SGTC_2742 clothiapine 36.27 µM -0.191734574412483 0.419568728874757 no 1995 0.423975060971678 2769 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1540 guanosine 70.6 µM -0.192258155937608 0.419357201046893 no 1996 0.423769996812298 2722 6802 Guanosine is a purine nucleoside
SGTC_66 0109-0187 42.4 µM -0.195206887477712 0.418166345380224 no 1997 0.42261549367808 2688 759417
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.195959309941211 0.417862596546149 no 1998 0.422321007219014 2900 5393153
SGTC_2088 5278280 127.392 µM -0.19602431712372 0.417836355798745 no 1999 0.422295566453345 2840 791502
SGTC_1557 sumaresinolic acid 42.3 µM -0.19684531702845 0.417504983153807 no 2000 0.421974293490115 2753 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1092 toremifene 6.32 µM -0.200873188963819 0.415880103156951 no 2001 0.420398866253186 2750 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2771 fluoxetine 41.05 µM -0.201910745189195 0.415461775230724 no 2002 0.419993250818575 2941 3386 A selective serotonin reuptake inhibitor.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.201943612919047 0.415448524992094 no 2003 0.419980403109738 2819 4330530
SGTC_814 3342-0569 96 µM -0.202054167035391 0.415403957106349 no 2004 0.419937189096106 2755 4346283
SGTC_2052 5265182 7.135 µM -0.202125138718299 0.415375346733902 no 2005 0.419909447794986 2899 1239884
SGTC_2442 5158906 48.48 µM -0.203888887904456 0.414664482011573 no 2006 0.419220164427153 2922 1893835
SGTC_1877 wortmannin 25 µM -0.204696619283439 0.414339025593745 no 2007 0.418904580951952 2895 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2282 7944268 200 µM -0.207573086754429 0.413180499569613 no 2008 0.417781160151469 2958 2970414
SGTC_2398 5228213 48.84 µM -0.208214532691988 0.412922253488107 no 2009 0.417530730903401 2935 80771 YMR134W ERG29
SGTC_523 1934-0222 13.7 µM -0.212493819543334 0.411200382337079 no 2010 0.41586089949207 2795 1361595
SGTC_2722 naftopidil 47.16 µM -0.215154190691509 0.410130779228469 no 2011 0.414823552509831 2814 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.216208545467197 0.409707059995155 no 2012 0.414412596380238 2797 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_738 1315-0003 72.4 µM -0.217638605130219 0.409132522779858 no 2013 0.413855351429265 2951 6251474
SGTC_2505 galangin 7.89 µM -0.21775530684077 0.40908564558683 no 2014 0.413809884434144 2757 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1552 6-methylflavone 10.6 µM -0.218831255162966 0.408653515853671 no 2015 0.413390749396116 2802 689013
SGTC_950 1165-0508 94.1 µM -0.219394545297112 0.408427327658494 no 2016 0.413171359377227 2881 6148369
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.219849473047962 0.408244674456027 no 2017 0.412994194083062 2799 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2274 7947094 46.08 µM -0.220083683459474 0.408150646895534 no 2018 0.412902990998116 2786 2971028
SGTC_3311 9131146 2.8755 µM -0.220654702874214 0.407921424085447 no 2019 0.412680651969342 2848 4900406 YPR165W RHO1
SGTC_249 wiskostatin 11.211 µM -0.222903990466071 0.407018805794004 no 2020 0.411805115289895 2806 2775510 A n-wasp and actin depolymerizer.
SGTC_237 nikkomycin 200 µM -0.223525321592122 0.40676955817007 no 2021 0.411563338918386 2952 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_863 0466-0191 129 µM -0.224297530906465 0.406459838242258 no 2022 0.411262898660362 2912 765160 YPR165W RHO1
SGTC_2948 9070189 9.45 µM -0.225555434341339 0.405955440092441 no 2023 0.4107736029084 2965 6473636 YDL196W YDL196W
SGTC_3198 9112019 49.47 µM -0.225737614527303 0.405882401816808 no 2024 0.410702750460317 2791 45595555
SGTC_2819 7996655 46.38 µM -0.225905934979813 0.405814922990199 no 2025 0.410637290847999 2887 6456960
SGTC_1370 2001-0092 44.6 µM -0.22603758894988 0.405762145523106 no 2026 0.410586092519284 2994 790957
SGTC_481 bay k-8644 50 µM -0.22781099766095 0.405051388433381 no 2027 0.409896588294822 2817 2303 A calcium channel antagonist.
SGTC_661 1304-0007 33.6 µM -0.22813629297764 0.404921048590399 no 2028 0.409770143108113 2817 3117130
SGTC_1035 k081-0041 55.2 µM -0.228388856856152 0.404819858168044 no 2029 0.409671975749445 2873 731709
SGTC_142 0335-0849 62.6745 µM -0.229442824524411 0.404397651853196 no 2030 0.409262377317593 2833 3889043 YPR107C YTH1
SGTC_285 1486-1325 46 µM -0.229792364359972 0.404257655105358 no 2031 0.409126559165229 2917 22310230
SGTC_1827 berberine 7.24 µM -0.229937391185106 0.404199572951809 no 2032 0.409070210347401 2805 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1747 st037496 66.6 µM -0.23050928666832 0.403970553702476 no 2033 0.408848024026318 2827 723305
SGTC_1989 st071868 50.2 µM -0.231286149421795 0.403659506716612 no 2034 0.408546253083169 2960 16414057
SGTC_676 falcarinol 140 µM -0.231690168910889 0.403497765989013 no 2035 0.408389333856432 2984 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2896 9052656 71.43 µM -0.232138464802811 0.403318319448909 no 2036 0.408215235079593 2919 6469436
SGTC_2854 9024559 71.43 µM -0.232375196457663 0.403223567307442 no 2037 0.408123306029164 2906 3163529
SGTC_759 3486-0358 89.3 µM -0.232675807183339 0.403103255676532 no 2038 0.408006578364833 2981 875103
SGTC_1411 3909-8223 150 µM -0.234746045386192 0.402274946311627 no 2039 0.407202923541388 2936 X1411
SGTC_2278 7948257 134.34 µM -0.234826010502589 0.402242960770538 no 2040 0.407171889344509 2979 1247028
SGTC_1996 st072960 66.8 µM -0.236080965076984 0.401741072748873 no 2041 0.406684922087105 2903 1719405
SGTC_1955 wogonin 32.4 µM -0.236951282229328 0.401393106032026 no 2042 0.406347292571456 3064 5281703 A flavanone.
SGTC_1299 1079-1439 3.74 µM -0.238832093564595 0.400641394968193 no 2043 0.405617891589812 2845 323161
SGTC_2452 5863136 48.41 µM -0.23940283388618 0.400413357614564 no 2044 0.405396616384177 2791 2184096
SGTC_2165 5727197 32.143 µM -0.240661088847732 0.399910746128496 no 2045 0.404908899626742 3233 1361712
SGTC_1668 st014914 51.6 µM -0.24220025834869 0.39929614847112 no 2046 0.40431249743752 2865 2839556
SGTC_2280 7785178 200 µM -0.242864993779863 0.399030793529991 no 2047 0.404054992337516 2842 2954328
SGTC_2737 bleomycin 30.5 nM -0.244284455258623 0.398464316725584 no 2048 0.40350526087833 2853 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_562 3772-2733 112 µM -0.244603789462461 0.398336906683527 no 2049 0.403381614807906 2949 2876874 YIL048W NEO1
SGTC_910 3454-3003 490 µM -0.245020554180869 0.398170639482889 no 2050 0.403220258211803 2943 820824
SGTC_2976 9009005 19.48 µM -0.245090189569419 0.398142860427504 no 2051 0.40319329945174 3063 2993148
SGTC_1725 st036284 20.55 µM -0.245862560411553 0.397834779723435 no 2052 0.402894313401303 3086 707914
SGTC_1169 aniline yellow 25.8 µM -0.246051969941897 0.397759238400499 no 2053 0.402821001315597 2886 6051 A DNA damaging agent.
SGTC_1371 2421-0008 32.7 µM -0.246168201633812 0.397712884152601 no 2054 0.402776014839102 2879 2827552
SGTC_2309 7664088 163.95 µM -0.246229939587713 0.397688263086524 no 2055 0.402752120218519 2996 704922
SGTC_2416 tofa 880 nM -0.247880906864497 0.39703000959901 no 2056 0.402113276538292 2869 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1198 1612-1005 86.7 µM -0.248506676776616 0.396780586806 no 2057 0.401871202378811 3037 6998509
SGTC_1567 st069303 68.4 µM -0.248688238198885 0.396708226959739 no 2058 0.401800973814399 2955 5581319
SGTC_2113 5491891 107.031 µM -0.249990724552991 0.396189235909076 no 2059 0.401297260840862 2863 789979
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.250577786623248 0.395955374180354 no 2060 0.401070278798737 2949 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1705 st027868 56.3335 µM -0.25061085990908 0.395942200237503 no 2061 0.401057492315814 2925 292948
SGTC_2867 9039098 71.43 µM -0.251028682308429 0.39577578103845 no 2062 0.400895966877751 2831 6463460
SGTC_229 benomyl 22.8748 µM -0.251483376131075 0.395594697491719 no 2063 0.400720206612403 2925 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1403 3909-7815 62.9 µM -0.251747714290074 0.395489434169716 no 2064 0.400618036881217 2824 6615483
SGTC_1219 1469-0211 33.1 µM -0.251748637121247 0.395489066698192 no 2065 0.400617680208286 2962 6822282
SGTC_818 4072-2707 53.5 µM -0.252208467128275 0.39530597387923 no 2066 0.400439966880417 2815 882871
SGTC_131 0141-0277 33.849 µM -0.253024214055047 0.394981220721599 no 2067 0.400124750885758 3036 1547771
SGTC_1838 st055369 84.5 µM -0.253233852881265 0.394897774170926 no 2068 0.400043754017847 2827 676036
SGTC_1062 mesoridazine 14.2 µM -0.255143230353427 0.394137970512681 no 2069 0.399306237891307 2838 4078 A neuroleptic.
SGTC_3208 9114115 49.47 µM -0.255225365879303 0.394105295118011 no 2070 0.399274520264055 2931 650895
SGTC_2213 7173844 200 µM -0.255384509205506 0.394041986376756 no 2071 0.399213067035198 2872 892728
SGTC_526 4469-0568 170 µM -0.255695536913299 0.393918264656325 no 2072 0.399092970832335 2840 2901964
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.25660888261327 0.393555012641107 no 2073 0.398740358618833 2840 364106
SGTC_1694 st024011 44.9 µM -0.257088993256606 0.393364102173249 no 2074 0.398555037081948 2880 2787533
SGTC_1000 4048-0884 8.67 µM -0.257373891308216 0.393250827861251 no 2075 0.398445077940126 2994 13040088
SGTC_312 4092-0653 6.84 µM -0.257888580764445 0.393046212331359 no 2076 0.398246449041889 2957 1148278
SGTC_875 0709-0210 25.7 µM -0.257982928259197 0.393008707552582 no 2077 0.39821004132486 2880 6251364
SGTC_1773 st048542 73.5835 µM -0.258288409091839 0.39288728039564 no 2078 0.39809216552965 2836 3237138
SGTC_1396 3511-0007 98.6 µM -0.259579081503139 0.392374359518933 no 2079 0.397594236941011 2984 X1396
SGTC_1462 k081-0014 26.5 µM -0.259583749610455 0.392372504724084 no 2080 0.397592436333859 2889 3270634
SGTC_2638 epoxomicin 18 µM -0.261182053293145 0.391737589318115 no 2081 0.396976058657032 2975 9915668 A protesome inhibitor.
SGTC_896 0964-0007 44.5 µM -0.262399802689725 0.391254039915678 no 2082 0.396506612391627 2899 6756758
SGTC_377 3970-0964 33.1 µM -0.262583064814346 0.391181283895859 no 2083 0.396435977227776 2851 16481235
SGTC_713 1488-1073 324 µM -0.26418206503613 0.390546634277752 no 2084 0.395819815156632 2852 3312542
SGTC_472 calcifediol 10 µM -0.264770437090792 0.390313180317784 no 2085 0.395593156061862 2940 5283731 A vitamin D metabolite.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.265090906362651 0.390186041315866 no 2086 0.395469716244494 2852 3256 An antibiotic and ribosome inhibitor.
SGTC_1098 clofazimine 15.1 µM -0.265268875884427 0.390115440967698 no 2087 0.39540116965944 2985 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2168 5727979 200 µM -0.265648057913471 0.389965031889838 no 2088 0.39525513503608 2819 695210
SGTC_2 0422-0095 29 µM -0.266183362001284 0.389752722359198 no 2089 0.395048998066821 2895 6790840
SGTC_2625 euphol 100 µM -0.266491991499173 0.389630330273292 no 2090 0.394930163170295 3029 6708538 A triterpene alcohol.
SGTC_1759 st043059 70 µM -0.266574279162663 0.389597699599253 no 2091 0.394898480726307 2878 669426
SGTC_3024 9090631 49.47 µM -0.266681775739179 0.389555073656053 no 2092 0.394857093378958 2983 25236383
SGTC_1180 1193-0155 285 µM -0.268427531089352 0.388863010339118 no 2093 0.394185125050579 3022 2921347
SGTC_1828 st055811 49 µM -0.268853723025964 0.388694110102667 no 2094 0.394021124896596 3028 5877589
SGTC_1414 3917-0015 5.4 µM -0.268970508725168 0.388647831499252 no 2095 0.393976188628211 2962 6618702
SGTC_700 3453-2283 142 µM -0.269429270708394 0.388466053449074 no 2096 0.393799681954183 3063 565664
SGTC_2597 laccaic acid a 100 µM -0.270373839319657 0.388091858241194 no 2097 0.393436332034913 3021 5491415 A textile dye.
SGTC_1615 st002656 86.5 µM -0.271086635732946 0.387809549405765 no 2098 0.39316220000243 2856 1584458
SGTC_1461 k072-0203 53.8 µM -0.271401213083713 0.387684977328192 no 2099 0.393041234569805 2866 5418714
SGTC_1829 berberine 14.4 µM -0.27156896240385 0.387618553617566 no 2100 0.392976733609491 3058 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1968 st069590 43.6 µM -0.272627067400269 0.387199651582461 no 2101 0.392569951531673 3035 6384066
SGTC_551 k048-0028 34.9 µM -0.273901251395177 0.386695378552149 no 2102 0.392080254938115 3051 6836383
SGTC_1807 st050092 58.9 µM -0.274104524240649 0.386614948642855 no 2103 0.392002148552394 2898 5008496
SGTC_147 4466-0538 29.23 µM -0.27626349829286 0.385760998576272 no 2104 0.391172844731125 3112 6742687 YHR072W ERG7
SGTC_2461 5755302 26.15 µM -0.27678936291529 0.38555308429599 no 2105 0.390970924680403 3042 2788904
SGTC_2111 5486399 200 µM -0.277587896826654 0.385237426002924 no 2106 0.390664362039436 2903 689674
SGTC_2543 pimpinellin 60.67 µM -0.277799411093412 0.385153827712479 no 2107 0.390583171637804 2908 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2021 4019055 173 µM -0.277858028600631 0.385130660841868 no 2108 0.390560671971507 3035 44827708 YER133W GLC7
SGTC_1780 st038448 24.544 µM -0.279053792821936 0.384658159290976 no 2109 0.390101771503874 3080 728868 YDL195W SEC31
SGTC_815 1582-0027 36.9 µM -0.280303020949012 0.384164714625411 no 2110 0.38962251663442 2998 3128206
SGTC_1024 4507-0395 26 µM -0.280413646229367 0.384121026713916 no 2111 0.389580084341139 3062 4201836
SGTC_3331 9141060 1.957 µM -0.280458241719348 0.384103415569761 no 2112 0.389562979320248 2900 4906567 YPR165W RHO1
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.280780678910182 0.383976089460235 no 2113 0.389439311861088 2916 1377
SGTC_1042 0350-0096 82 µM -0.282278795715808 0.383384667745522 no 2114 0.388864871650599 2874 3122515
SGTC_544 k015-0020 52.4 µM -0.282828261143832 0.3831678195706 no 2115 0.388654244594377 2938 3008304
SGTC_2870 9038528 12.99 µM -0.284211754481904 0.382621982035395 no 2116 0.388124053986189 3028 6463316
SGTC_3053 9095903 49.47 µM -0.2863687377236 0.381771440438239 no 2117 0.38729785809356 2960 17174018
SGTC_174 3553-0389 74.3 µM -0.287657525407918 0.381263517666489 no 2118 0.386804453057778 3048 738071
SGTC_540 1187-0821 17.3 µM -0.290504810595644 0.380142103016378 no 2119 0.385715035534629 2916 847520
SGTC_976 1348-1067 47.6 µM -0.293450111783954 0.378983143757964 no 2120 0.384589063379738 2957 5310671 YGL099W LSG1
SGTC_1043 0916-0009 19.3 µM -0.294738362870113 0.378476565393945 no 2121 0.384096877463451 3124 3101130
SGTC_287 k060-0039 29.6 µM -0.296763549645481 0.377680624511785 no 2122 0.383323517812492 3068 5861974
SGTC_2018 5133068 143 µM -0.297541113073496 0.377375163506717 no 2123 0.383026712351712 2883 785362
SGTC_300 r073-0011 5.04 µM -0.298027919578581 0.377183963596112 no 2124 0.382840927299406 3018 2735780
SGTC_2511 berberine 10.47 µM -0.298046080194084 0.377176831348299 no 2125 0.382833996995222 2940 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3209 9113616 49.47 µM -0.301101219479294 0.375977579794271 no 2126 0.381668655572178 3145 16649353
SGTC_2002 4023503 131 µM -0.302369804021124 0.375479965908342 no 2127 0.381185085481195 3064 4736863 YCR052W RSC6
SGTC_477 mead ethanolamide 10 µM -0.304440092874258 0.374668321257328 no 2128 0.380396313373388 2906 16061185
SGTC_333 3486-0131 40.1 µM -0.304912720730483 0.374483107940321 no 2129 0.380216313543209 3110 6744690
SGTC_2665 lovastatin 100 µM -0.307399301862369 0.37350914485608 no 2130 0.379269729757581 2969 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2035 5154463 94.595 µM -0.30758219685344 0.373437538952799 no 2131 0.379200134365883 3099 2769623
SGTC_2922 7999257 32.47 µM -0.307592474086851 0.373433515404289 no 2132 0.379196223778523 2936 2988377
SGTC_1086 cerivastatin 2.18 µM -0.307756481573727 0.373369308154963 no 2133 0.379133819006193 2969 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_734 2023-0417 80 µM -0.308117563480005 0.373227960684121 no 2134 0.378996438612192 3051 3935732
SGTC_899 1083-0020 478 µM -0.308766183200185 0.37297409783126 no 2135 0.378749697451694 3119 767123
SGTC_2626 ethyl orsellinate 100 µM -0.308793889141854 0.372963255248037 no 2136 0.378739158945536 2928 75653 A natural product.
SGTC_2177 5811945 192 µM -0.309764233331939 0.372583579383091 no 2137 0.37837012615396 3111 5343475
SGTC_444 curcumin 90.4 µM -0.309915338093129 0.372524466305028 no 2138 0.378312669288607 3072 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2745 rifampicin 24.3 µM -0.309934339886457 0.372517032903383 no 2139 0.378305444137673 2997 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_858 0438-0351 2.77 µM -0.310357635795036 0.372351454085625 no 2140 0.378144503163921 2980 2799119
SGTC_93 0109-0045 59.227 µM -0.310590701995151 0.372260296664468 no 2141 0.378055898287576 2927 88733
SGTC_2732 terfenadine 20 µM -0.311355476793803 0.371961226378698 no 2142 0.377765198602784 2942 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_365 0121-0052 13.6 µM -0.313475255710537 0.37113267691944 no 2143 0.376959808552184 3086 3101739
SGTC_2744 captopril 92.04 µM -0.313508185992839 0.371119810291643 no 2144 0.376947301213005 3047 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1327 1436-0082 2.18 µM -0.316513954861933 0.369945994815513 no 2145 0.375806217382823 2987 15992205
SGTC_2418 pentamidine 31.67 µM -0.31652124346684 0.36994314993013 no 2146 0.375803451715566 3043 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2693 st077581 40.7 µM -0.31808192898081 0.36933414793315 no 2147 0.375211395456268 3098 25238761
SGTC_3150 9097574 49.47 µM -0.319068162176649 0.368949474410547 no 2148 0.374837412870533 3134 17217476
SGTC_772 k072-0172 35.3 µM -0.320891047612237 0.368238816087507 no 2149 0.374146479221459 2977 5861980
SGTC_1815 st051655 58.2 µM -0.322312664293759 0.367684906387002 no 2150 0.373607919967624 3072 5984156
SGTC_2473 5854593 8.94 µM -0.322413818118298 0.367645503923357 no 2151 0.37356960867075 2917 2872951
SGTC_114 0364-0001 490.298 µM -0.322439173685417 0.367635627384046 no 2152 0.373560005624553 3027 4003655
SGTC_994 3910-0338 138 µM -0.322590447761664 0.3675767046936 no 2153 0.373502714436232 3157 3479481
SGTC_47 0149-0135 24.25 µM -0.323071305161749 0.367389426874584 no 2154 0.373320620564766 2958 5239155
SGTC_348 k064-0012 10.7 µM -0.325162689103637 0.366575270415869 no 2155 0.37252897269129 2932 5066323
SGTC_2379 9035213 200 µM -0.325202926967897 0.366559612058379 no 2156 0.372513746790352 3135 646551
SGTC_2319 6033012 152.6 µM -0.326201542011432 0.366171077376626 no 2157 0.37213593739647 2987 847246
SGTC_826 1683-5028 118 µM -0.326715283745804 0.365971247475692 no 2158 0.371941619669714 3059 722377
SGTC_2709 st078560 56 µM -0.327157791423083 0.365799154593961 no 2159 0.371774271661815 3148 17250903
SGTC_1570 verbenone 133 µM -0.32724424758263 0.365765534624031 no 2160 0.37174157841058 3171 29025 A natural terpanoid with antifungal properties.
SGTC_1221 2958-7315 257 µM -0.327519444198187 0.365658526534752 no 2161 0.3716375194325 3064 4562705
SGTC_2557 derrustone 83.84 µM -0.327553930654414 0.36564511747815 no 2162 0.371624479870072 3105 629853 An antioxidant.
SGTC_788 1182-0090 188 µM -0.330470526417641 0.364511679525683 no 2163 0.370522229667412 3173 5715185
SGTC_173 1273-0061 2.693 µM -0.332180416862422 0.363847737107958 no 2164 0.369876515039106 3091 2847414 YPL266W DIM1
SGTC_3107 9121808 49.47 µM -0.333127870626088 0.363480021052287 no 2165 0.36951888101611 2949 662681
SGTC_1460 k062-0059 9.15 µM -0.334120795287124 0.363094792241833 no 2166 0.369144204277577 2887 1373085
SGTC_2271 7849410 118.62 µM -0.335321632431821 0.362629083837585 no 2167 0.368691238543199 3129 972430
SGTC_2555 cholic acid 100 µM -0.336331224381907 0.362237701267651 no 2168 0.368310553165946 3150 6708657 Influences liver metabolism.
SGTC_393 acivicin 6.25 µM -0.3376986265706 0.36170783811643 no 2169 0.367795154930867 2973 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2023 5144124 124 µM -0.337959160405555 0.361606912274727 no 2170 0.3676969820494 2985 2830192
SGTC_588 3970-1144 52.9 µM -0.338242653918821 0.361497103228646 no 2171 0.367590167452303 3117 1888707
SGTC_1047 2043-3044 82 µM -0.339867220740689 0.360868059915423 no 2172 0.366978261417834 3023 669592
SGTC_2852 9023854 51.95 µM -0.343359696990592 0.359517024891328 no 2173 0.365663937829161 3168 19798528
SGTC_3168 9103419 49.47 µM -0.343468425318373 0.35947499232262 no 2174 0.365623045306635 3082 16649256
SGTC_432 NS 1619 61.3 µM -0.343539884561779 0.359447368289859 no 2175 0.365596170449266 3175 4552 A K+/calcium channel activator.
SGTC_618 k072-0232 33.2 µM -0.34378139855069 0.359354011552701 no 2176 0.365505345179989 3084 5872756 YGL099W LSG1
SGTC_425 3825-7017 13.1 µM -0.345385527147504 0.358734152239951 no 2177 0.36490227809134 3238 3397440
SGTC_791 1348-1292 225 µM -0.346448471262544 0.358323619459655 no 2178 0.364502851521053 3069 5437054
SGTC_2137 5261020 140 µM -0.347458994430861 0.357933484606094 no 2179 0.364123259727756 2995 763655
SGTC_2861 9024595 19.48 µM -0.347563520566488 0.357893138434355 no 2180 0.364084003245988 3047 16482810
SGTC_2815 7968870 71.43 µM -0.349207960341515 0.357258608294982 no 2181 0.363466595228037 3002 2977326 YHR190W ERG9
SGTC_1806 st050005 60.3 µM -0.349476405591787 0.357155062343961 no 2182 0.363365840566581 3026 5194765
SGTC_497 capsazepine 133 µM -0.349693357677424 0.357071386261676 no 2183 0.363284419568943 3037 2733484 A calcium channel blocker.
SGTC_2145 5634607 200 µM -0.351475406578156 0.356384329666352 no 2184 0.362615859870001 3016 308662
SGTC_2054 5233173 129 µM -0.35197482017629 0.356191867695886 no 2185 0.362428573134686 3168 6889
SGTC_3035 9091303 49.47 µM -0.355594340416699 0.354798089293876 no 2186 0.361072191337275 3061 25237002
SGTC_2178 5812956 200 µM -0.355747042528536 0.354739330431004 no 2187 0.36101500587628 2978 5403383
SGTC_647 0140-0236 81 µM -0.356144918742684 0.354586246270086 no 2188 0.360866019684706 3069 990837
SGTC_3050 9093513 49.47 µM -0.356414310732518 0.354482610161655 no 2189 0.360765156861016 3040 25236664
SGTC_754 3474-0146 171 µM -0.356534429559594 0.354436403470668 no 2190 0.360720186395319 2998 24762078
SGTC_987 1497-1013 404 µM -0.358346658790775 0.35373954480266 no 2191 0.360041952326909 3065 1676435
SGTC_2091 4-phenylthiadiazole 200 µM -0.360190346816038 0.353031091823517 no 2192 0.359352396527716 3037 270010
SGTC_543 3844-1095 191 µM -0.360460081495012 0.352927486590156 no 2193 0.359251551683523 3107 4230703
SGTC_3033 9090887 49.47 µM -0.362237847600161 0.352244918761334 no 2194 0.358587149493999 3045 19325384
SGTC_457 grayanotoxin iii 135 µM -0.36339891081737 0.35179938873625 no 2195 0.358153457643188 3132 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1565 sinapyl alcohol 95.1 µM -0.364392080550883 0.351418445192678 no 2196 0.357782624191433 3137 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1048 3161-0300 24.5 µM -0.365328700347438 0.351059328815539 no 2197 0.357433028501202 3078 2165101
SGTC_167 3672-0051 66.205 µM -0.365659359305936 0.350932580142529 no 2198 0.357309637766243 2989 3237971
SGTC_660 4031-1742 102 µM -0.366675018267254 0.350543360036741 no 2199 0.356930721545083 3068 6738706
SGTC_1374 2889-5571 141 µM -0.367264018392307 0.350317715655734 no 2200 0.356711045368681 3102 2853281
SGTC_294 k038-0071 157 µM -0.36903312300499 0.349640294244639 no 2201 0.356051517981791 3106 24152826
SGTC_61 0978-8327 98.565 µM -0.3700449699512 0.349253055124399 no 2202 0.355674491859097 3162 6150059 YHR072W ERG7
SGTC_1684 st024538 14.6195 µM -0.370620247465167 0.349032963334022 no 2203 0.355460199576065 3057 6732859
SGTC_2995 9067767 71.4286 µM -0.371128796741603 0.348838442956984 no 2204 0.355270801766 3116 11673567
SGTC_2659 sanguinarine 24.21 µM -0.371766450536147 0.34859459616629 no 2205 0.355033372375071 3037 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2953 9074162 66.49 µM -0.371844253450311 0.348564847637542 no 2206 0.355004406432542 3170 16451992
SGTC_2605 digitonin 300 nM -0.373397464640134 0.347971160752378 no 2207 0.354426323101211 3229 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_264 promethazine 12.5 mM -0.373581586631162 0.347900808118001 no 2208 0.354357817686752 3167 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1976 st070609 63.5 µM -0.373925379808894 0.347769459468393 no 2209 0.354229916769718 3005 682556
SGTC_1516 st013856 110 µM -0.373950301627239 0.347759938618907 no 2210 0.354220645777854 3152 5281404 A mutagen and neurotoxin.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.373956428201125 0.347757598106644 no 2211 0.354218366687054 3094 6708561
SGTC_1973 st070275 50.2 µM -0.374541460088924 0.34753412728888 no 2212 0.354000758383659 3129 17118334
SGTC_558 k064-0027 21.3 µM -0.374633295089076 0.347499052911284 no 2213 0.353966603789526 3147 5088526
SGTC_2629 bisabolol 100 µM -0.375370711626217 0.347217460085981 no 2214 0.353692391905231 3221 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_21 0849-0113 22.993 µM -0.376999976542885 0.346595601630642 no 2215 0.353086811172766 3069 1560156
SGTC_1805 st050013 60.3 µM -0.377347497176583 0.346463013227029 no 2216 0.352957689457413 3092 4037144
SGTC_1661 st013063 9.66 µM -0.377645495783751 0.346349333778461 no 2217 0.352846981195117 3079 721395
SGTC_448 monastrol 171 µM -0.37932667102059 0.345708264571193 no 2218 0.352222648193912 3115 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_190 3970-0790 3.722 µM -0.38046002113983 0.345276342552095 no 2219 0.351801983873596 3154 2832352
SGTC_94 0334-0113 514.748 µM -0.380712539204327 0.345180134829117 no 2220 0.35170828170857 3098 6795178
SGTC_422 cantharidin 155 µM -0.381486608585863 0.344885281845965 no 2221 0.351421103053781 3009 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2204 7233102 200 µM -0.382620722251653 0.34445345346859 no 2222 0.351000501636452 3074 2172480
SGTC_3281 9140613 49.47 µM -0.38274892705618 0.344404650578439 no 2223 0.350952966618984 3110 16013766
SGTC_3282 9108498 15.4605 µM -0.383044223240367 0.344292251953735 no 2224 0.350843487324827 3161 16459645
SGTC_1230 0170-0365 3.77 µM -0.38335106586479 0.344175472974338 no 2225 0.350729740375522 3204 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_134 0269-0018 6.916 µM -0.384370877771788 0.343787457058455 no 2226 0.350351790987939 3133 4378915
SGTC_1463 k081-0032 34.1 µM -0.384512052140885 0.343733756280085 no 2227 0.350299482448658 3144 977755
SGTC_3069 9117009 49.47 µM -0.385503834257744 0.343356585007028 no 2228 0.349932083130611 3104 41904981
SGTC_776 4476-4378 112 µM -0.386895897191342 0.342827451460803 no 2229 0.349416639328757 3159 2892008
SGTC_1850 st056238 17 µM -0.387234958495336 0.342698618350633 no 2230 0.349291135964031 3109 5393177
SGTC_1386 3228-0095 33.8 µM -0.388258932536592 0.34230965007474 no 2231 0.348912212577709 3204 870181
SGTC_146 3448-8650 53.125 µM -0.389954845463016 0.34166580608276 no 2232 0.3482849684934 3093 2891488 YIL048W NEO1
SGTC_920 mycophenolic acid 780.421 nM -0.390752628676672 0.341363091183073 no 2233 0.347990046667948 3101 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1895 st058434 18.3 µM -0.391270409743054 0.341166676305566 no 2234 0.347798684279064 3234 5393175
SGTC_356 1634-0012 32.5 µM -0.391399948935105 0.341117543683515 no 2235 0.347750815029268 3217 735457
SGTC_205 1486-1330 71.903 µM -0.392990097871338 0.340514639471651 no 2236 0.347163397493882 3112 4118834
SGTC_1049 3226-0134 66 µM -0.394582047411623 0.339911460529957 no 2237 0.346575682390648 3173 5702385
SGTC_2243 6634756 200 µM -0.395257302305037 0.33965573463111 no 2238 0.346326503539724 3321 885676
SGTC_2486 5283202 22.39 µM -0.395461319808747 0.339578485637079 no 2239 0.346251231197547 3126 1377751
SGTC_2569 tetrandrine 100 µM -0.395651842301387 0.339506352466085 no 2240 0.346180943328769 3135 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_654 1124-0271 80.9 µM -0.397127632592101 0.338947807085448 no 2241 0.345636671997115 3116 5403748
SGTC_615 k087-0205 167 µM -0.399935405289606 0.337886121445488 no 2242 0.344602047000041 3111 9642773
SGTC_2297 7971671 152.32 µM -0.400018918735192 0.337854562715644 no 2243 0.344571291210775 3276 909016
SGTC_3072 9116419 49.47 µM -0.400696876195369 0.337598412919816 no 2244 0.344321655481957 3141 17170162
SGTC_3317 9138495 8.753 µM -0.401218991824252 0.337401195447113 no 2245 0.344129449638426 3134 17020139
SGTC_3111 9122088 49.47 µM -0.402460077317093 0.336932582560842 no 2246 0.343672731890659 3123 16876704
SGTC_1325 1431-0015 227 µM -0.402998825638796 0.336729239012736 no 2247 0.343474544207322 3106 1103340
SGTC_2080 5212524 12.4 µM -0.40325848584589 0.336631250683778 no 2248 0.343379039170433 3224 260183
SGTC_1664 st014217 9.02 µM -0.403283276773596 0.336621895877264 no 2249 0.343369921397915 3217 3982782
SGTC_2464 5717415 7.67 µM -0.404338340404205 0.336223863525003 no 2250 0.342981967620996 3112 5285744
SGTC_1254 0550-0035 264 µM -0.405497457229907 0.335786787726815 no 2251 0.342555943569081 3237 15121435
SGTC_3333 9141820 12.094 µM -0.405621704852321 0.335739950024589 no 2252 0.342510289227485 3096 1939433
SGTC_1916 st067606 49.2 µM -0.405719951216473 0.335702915839039 no 2253 0.342474190583566 3169 19590279
SGTC_778 3456-2434 196 µM -0.407683626927012 0.334963039002718 no 2254 0.341752979745864 3226 5539063
SGTC_2781 5567276 71.43 µM -0.408587031036197 0.334622867757292 no 2255 0.341421374850219 3271 2853274
SGTC_2936 9038235 15.59 µM -0.410608851305791 0.333862055821683 no 2256 0.340679686162699 3092 4749415
SGTC_1038 k292-0204 154 µM -0.410910301492355 0.333748678358972 no 2257 0.340569154222289 3067 4454212
SGTC_2008 4012253 172 µM -0.412638439411077 0.333099007132022 no 2258 0.339935766938599 3102 603940
SGTC_3143 9086658 49.47 µM -0.413319926103883 0.332842948481035 no 2259 0.339686116355486 3173 25236626
SGTC_56 0957-0365 83.25 µM -0.414362773983186 0.3324512645691 no 2260 0.339304223650207 3239 6752360
SGTC_2372 9071633 200 µM -0.414865943190063 0.332262344300557 no 2261 0.339120021198492 3265 21321366
SGTC_358 0075-0058 9.45 µM -0.418175030363751 0.331020975653565 no 2262 0.337909575297721 3367 1069125
SGTC_1085 doxorubicin 7.67 µM -0.419118755297599 0.330667286752781 no 2263 0.337564672177791 3254 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2607 solasodine 47.35 µM -0.419333879954589 0.330586683551683 no 2264 0.337486069656801 3146 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2636 apigenin dimethyl ether 100 µM -0.419785881816543 0.330417352474735 no 2265 0.337320939744374 3281 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2514 salinomycin 42.74 µM -0.420411987799342 0.330182855040565 no 2266 0.337092256106549 3293 23682228 A polyether potassium ionophore.
SGTC_1347 1493-0251 600 nM -0.420848154841072 0.330019535437482 no 2267 0.336932982753918 3260 3986378
SGTC_2453 5731132 22.18 µM -0.421817054884469 0.329656853733414 no 2268 0.336579278081993 3285 1362040
SGTC_1641 st009299 47.1 µM -0.422936825789238 0.329237897059113 no 2269 0.336170676857958 3238 4046054
SGTC_210 3551-0445 56.827 µM -0.42487920142741 0.328511675534426 no 2270 0.335462368597898 3273 2865180 YOR207C RET1
SGTC_1491 4138-0063 26.5 µM -0.425446710033109 0.328299615701714 no 2271 0.335255530655475 3237 23883227
SGTC_568 1193-0097 7.48 µM -0.427819054527448 0.327413745904572 no 2272 0.334391431565128 3215 3646150
SGTC_3218 9131285 49.47 µM -0.431195971315147 0.326154428904126 no 2273 0.33316294149788 3344 17156417
SGTC_2853 9015042 58.44 µM -0.43131268061182 0.326110941084967 no 2274 0.333120515661781 3053 6457456
SGTC_2217 6934799 96.0675 µM -0.432057490953762 0.325833468121135 no 2275 0.332849814617927 3242 675606
SGTC_474 dl-dihydrosphingosine 5 µM -0.433268633358965 0.325382472952056 no 2276 0.332409811380733 3297 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1530 rhein 70.4 µM -0.433651332037616 0.325240019898879 no 2277 0.332270826434989 3205 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1863 st057641 20.1 µM -0.436979284442628 0.324002324799189 no 2278 0.331063185754356 3242 3921635
SGTC_1975 st070967 30.8 µM -0.437512138087414 0.323804331902395 no 2279 0.330869987603609 3326 261391
SGTC_1555 citronellol 128 µM -0.438129849800627 0.323574870609296 no 2280 0.330646078606204 3239 8842 A terpine precursor.
SGTC_874 0599-0792 117 µM -0.4389235309423 0.323280140425451 no 2281 0.330358472915562 3324 765305
SGTC_1513 0337-0559 19 µM -0.439119995157269 0.323207201370986 no 2282 0.330287295774534 3163 775073
SGTC_2580 diallyl disulphide 81.36 µM -0.439860212428582 0.322932450306043 no 2283 0.33001917717299 3167 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1531 st059297 52.4 µM -0.441946978833629 0.322158412622092 no 2284 0.329263787074514 3279 7566702
SGTC_598 3937-0236 20.2 µM -0.442392865624821 0.32199312105671 no 2285 0.329102470388242 3247 1379313
SGTC_1320 1313-0481 95.3 µM -0.443149458419764 0.321712730418982 no 2286 0.328828816675256 3345 6813365 YLR208W SEC13
SGTC_624 k048-0052 28 µM -0.443699918429235 0.321508795652065 no 2287 0.328629777226703 3211 6835531
SGTC_1018 4259-0013 28.1 µM -0.443819428362019 0.321464526641866 no 2288 0.328586570351539 3280 6801262
SGTC_2053 5265679 138 µM -0.446710597555153 0.320394350246189 no 2289 0.327542014568452 3161 764595
SGTC_1760 st045453 10.4495 µM -0.446821778328842 0.320353226025961 no 2290 0.327501872738907 3302 3323419 YIL048W NEO1
SGTC_2371 9071574 200 µM -0.447147584614291 0.320232727522934 no 2291 0.327384251832074 3274 45596039
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.447278835077105 0.320184190277971 no 2292 0.327336873307103 3130 688667
SGTC_782 0083-0095 30.5 µM -0.450275618907922 0.319076799314113 no 2293 0.326255858403488 3169 3591729 An indicator and reagent.
SGTC_960 1222-0186 7.7 µM -0.450314604569223 0.319062403685909 no 2294 0.326241804888488 3306 3126296
SGTC_2602 kawain 100 µM -0.450801056326249 0.318882802169991 no 2295 0.326066469961555 3268 5369129
SGTC_1437 4092-1038 11.6 µM -0.451556163420015 0.318604095399156 no 2296 0.32579437803782 3209 3977136
SGTC_3081 9117243 49.47 µM -0.452453733853013 0.318272939482535 no 2297 0.325471072181925 3340 45595589
SGTC_2071 5230951 39.92 µM -0.452517238669751 0.318249515067415 no 2298 0.325448202647139 3314 1799272
SGTC_1990 st072050 59.8 µM -0.453348558522116 0.317942941113875 no 2299 0.325148886022031 3188 17233948
SGTC_503 tyrphostin 8 294 µM -0.454293039594912 0.317594786943301 no 2300 0.324808962578625 3268 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_70 0141-0289 43.283 µM -0.45676645586272 0.316683802111742 no 2301 0.323919459322574 3230 352408
SGTC_2676 harmalol 100 µM -0.457097855985583 0.316561828272164 no 2302 0.323800355634587 3300 5459187 A monoamine oxidase inhibitor
SGTC_1912 st060209 90.8 µM -0.457565238064585 0.316389839346927 no 2303 0.323632411319418 3232 688787
SGTC_3287 9117173 37.0625 µM -0.45768381420956 0.316346211586971 no 2304 0.323589809085525 3227 2789709
SGTC_989 1501-0895 10.3 µM -0.458137958578154 0.316179141746425 no 2305 0.323426664732536 3326 2830112
SGTC_2674 ligustilide 100 µM -0.459154349111709 0.315805369765579 no 2306 0.323061665145092 3289 5319022 A signalling regulator.
SGTC_1436 4092-1007 8.32 µM -0.459851231088765 0.315549204055305 no 2307 0.322811503794939 3210 2881121
SGTC_2497 7-hydroxyflavone 100 µM -0.460439084717268 0.315333184789231 no 2308 0.322600542926621 3326 5281894
SGTC_165 k038-0023 64.381 µM -0.462014277474308 0.314754658139351 no 2309 0.322035540916475 3212 46368543
SGTC_1025 k007-0731 70 µM -0.462383197285979 0.314619229265237 no 2310 0.321903273344169 3174 6256118
SGTC_1160 4092-0570 10.5 µM -0.464256131232702 0.313932068232135 no 2311 0.321232124972899 3222 4994975
SGTC_1700 st030840 7.9285 µM -0.464577671280467 0.31381416313444 no 2312 0.32111696271921 3307 5499307
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.467152351165438 0.312870743531186 no 2313 0.320195440733859 3334 6708760
SGTC_2375 9072683 200 µM -0.467753978077384 0.312650470367145 no 2314 0.319980267653319 3382 16798029
SGTC_368 fentichlor 4.58 µM -0.468597105025773 0.312341889573815 no 2315 0.319678823486997 3260 7329 A pesticide.
SGTC_148 3253-0744 288.01 µM -0.469116132034097 0.312151993358176 no 2316 0.319493314354126 3319 6893655
SGTC_224 benfluorex 43.875 µM -0.470834241227108 0.311523745592037 no 2317 0.318879555140091 3325 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1379 2144-0755 36.5 µM -0.470999547901926 0.311463328061867 no 2318 0.318820528876578 3393 5392327
SGTC_3318 9139014 38.6185 µM -0.472165159066526 0.311037455885067 no 2319 0.318404453142 3241 16643984
SGTC_2198 6589944 200 µM -0.473422736996659 0.310578265988979 no 2320 0.317955805764099 3289 5290268
SGTC_2308 7584454 197.62 µM -0.473734015433624 0.310464651818373 no 2321 0.317844796791551 3415 893577
SGTC_2892 9047358 58.44 µM -0.474689149664937 0.310116148256578 no 2322 0.317504276399696 3246 6466771
SGTC_3006 9075424 71.4286 µM -0.476838502271723 0.309332529420686 no 2323 0.316738563211653 3236 7465181
SGTC_107 0358-0022 2.6945 µM -0.47783304297575 0.308970229091516 no 2324 0.316384520435773 3290 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_711 k292-0785 179 µM -0.478304451092666 0.308798565127873 no 2325 0.316216764391723 3255 4146315
SGTC_3065 9113888 49.47 µM -0.47846559932813 0.308739892336267 no 2326 0.316159426596525 3411 16648368
SGTC_2401 5128683 200 µM -0.478693112441449 0.308657064931503 no 2327 0.316078483188601 3240 708373
SGTC_1929 genistein trimethyl ether 50.5 µM -0.479507853590473 0.308360533784063 no 2328 0.315788691235245 3406 136420
SGTC_2225 6654152 15.4 µM -0.482369699104338 0.307319935245039 no 2329 0.314771671164143 3297 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1017 4239-0030 168 µM -0.48247491229745 0.307281708046282 no 2330 0.314734308028954 3244 1149593
SGTC_2947 9072639 7.68 µM -0.484928904301832 0.306390691701877 no 2331 0.313863389118109 3343 16488146
SGTC_610 4215-0184 155 µM -0.486959614307718 0.305654228525383 no 2332 0.313143475527727 3324 5605015
SGTC_1335 1486-0900 202 µM -0.48709125122831 0.305606515776122 no 2333 0.313096833029189 3318 X1335
SGTC_2343 7990716 14.84 µM -0.487794381125179 0.30535171720093 no 2334 0.312847745875168 3230 6456862
SGTC_1207 2099-0101 141 µM -0.488063307513746 0.305254289199735 no 2335 0.312752499983627 3345 5837381
SGTC_1655 st012546 55.1 µM -0.488373102778338 0.305142072117355 no 2336 0.312642795021669 3318 720985 YLR208W SEC13
SGTC_940 3232-1287 54.8 µM -0.488837702104566 0.304973814721972 no 2337 0.312478301825214 3363 1585493 YIL048W NEO1
SGTC_820 1582-0060 59.9 µM -0.48982654065305 0.304615838264295 no 2338 0.312128324088048 3256 3848840
SGTC_3023 9089636 49.47 µM -0.491301624483155 0.3040821803553 no 2339 0.311606565534632 3407 17249241
SGTC_3098 9119039 49.47 µM -0.492402112098737 0.303684315992915 no 2340 0.311217553241179 3356 17161528
SGTC_1766 st045414 44.774 µM -0.492408535353236 0.303681994446267 no 2341 0.311215283297805 3309 253960
SGTC_1579 chlormadinone acetate 49.4 µM -0.493282682383624 0.303366126803014 no 2342 0.310906431471892 3364 45114258 A steroidal progestin.
SGTC_716 1683-5115 658 µM -0.493460190620047 0.303302003233303 no 2343 0.310843730886196 3383 723597
SGTC_1732 st034308 51.822 µM -0.493954144500173 0.303123597852359 no 2344 0.310669282271222 3178 830119
SGTC_2822 7994718 71.43 µM -0.494822942745682 0.302809920791189 no 2345 0.310362553965918 3296 1018011
SGTC_1992 st073643 23.3 µM -0.496606894849364 0.302166286236316 no 2346 0.309733145024059 3295 3161292
SGTC_1699 st031318 29.054 µM -0.496875198670825 0.302069537675744 no 2347 0.309638531007532 3356 5340658
SGTC_2127 5253358 187.912 µM -0.496944013671971 0.302044725688843 no 2348 0.309614266282537 3226 20612
SGTC_1666 st014829 29 µM -0.497094213263678 0.301990572793929 no 2349 0.309561307576023 3306 3858230
SGTC_2982 9019404 25.97 µM -0.499922168536676 0.300971798188895 no 2350 0.308564941018714 3251 22333232
SGTC_2730 imipramine 71.33 µM -0.500003029715026 0.300942690642069 no 2351 0.308536472069184 3387 3696 A tricyclic antidepressant.
SGTC_2405 ticlatone 3.52 µM -0.50031319132074 0.300831053740534 no 2352 0.308427283556079 3075 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2990 9074105 71.4286 µM -0.500844348161535 0.300639917116082 no 2353 0.308240335790013 3344 6502001
SGTC_641 4092-0595 30 µM -0.501411466516006 0.300435900286629 no 2354 0.308040785778939 3366 786260
SGTC_274 sirtinol 40.1 µM -0.502190413594545 0.30015578156317 no 2355 0.307766792804699 3310 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3156 9099931 49.47 µM -0.503055229359858 0.299844921858778 no 2356 0.307462721238345 3236 18111053
SGTC_524 r073-0010 27.8 µM -0.503078043976716 0.299836723074087 no 2357 0.307454701347053 3253 2772106
SGTC_2031 5180455 200 µM -0.50308250047127 0.299835121575836 no 2358 0.307453134791852 3308 29949
SGTC_2043 5101342 149 µM -0.504435052049174 0.299349243955152 no 2359 0.306977845762033 3294 678451
SGTC_2024 5144227 134 µM -0.505287462305071 0.29904321585643 no 2360 0.306678473766691 3384 3475211
SGTC_2696 st077691 74.316 µM -0.505670100617856 0.298905889159304 no 2361 0.306544130629397 3397 757133
SGTC_1739 st037196 92.5 µM -0.506732785027005 0.298524648167949 no 2362 0.306171161770207 3414 612214
SGTC_1898 st060199 18.6 µM -0.507159549709742 0.298371607427634 no 2363 0.306021437258051 3324 688866
SGTC_158 k038-0087 26.446 µM -0.507877212495303 0.298114329186538 no 2364 0.305769728222897 3251 X158
SGTC_2069 5228469 200 µM -0.509020834585703 0.297704555823392 no 2365 0.3053688101905 3362 2835210
SGTC_927 2425-1185 123 µM -0.510089227677818 0.29732197025671 no 2366 0.304994475877829 3237 730375
SGTC_1985 st071382 65.5 µM -0.510258814788196 0.29726126272901 no 2367 0.30493507616331 3379 6123237
SGTC_277 nystatin 15.5 µM -0.510486377639003 0.297179810380084 no 2368 0.304855377896491 3239 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_921 1561-0023 372 µM -0.510570375139504 0.297149747445832 no 2369 0.304825962186135 3339 24050882
SGTC_882 0843-0131 351 µM -0.510873765293307 0.297041174865094 no 2370 0.30471972623643 3416 5425421
SGTC_2147 5545932 89.7195 µM -0.512550678425066 0.296441394658433 no 2371 0.304132830817496 3364 797404
SGTC_1702 st027038 51 µM -0.513389409052945 0.296141614922949 no 2372 0.303839476279765 3352 5521182
SGTC_1803 st050068 52.4 µM -0.514281785090705 0.29582281401756 no 2373 0.303527497384323 3450 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2755 lomerizine 42.69 µM -0.514630328598273 0.295698339844629 no 2374 0.30340568378394 3309 3949 A calcium channel blocker.
SGTC_176 1486-1328 72.834 µM -0.514973801430393 0.29557570009692 no 2375 0.303285663723722 3359 22310231
SGTC_614 0462-0418 107 µM -0.515863870089688 0.295258002766284 no 2376 0.302974744931616 3295 5188303
SGTC_2440 5628896 157.78 µM -0.516302653832759 0.295101443020284 no 2377 0.302821521503082 3302 5522048
SGTC_2652 actinonin 100 µM -0.516631289054519 0.29498420974094 no 2378 0.302706784705979 3312 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3097 9117246 49.47 µM -0.517374106167014 0.294719305411458 no 2379 0.302447515890173 3424 16423892
SGTC_2195 6536160 144.242 µM -0.517502332086668 0.294673588435736 no 2380 0.302402770697331 3276 3834386
SGTC_145 3737-0113 38.366 µM -0.518071106833586 0.294470840008314 no 2381 0.302204329187901 3427 6849351
SGTC_446 go6976 132 µM -0.519095862896396 0.294105712692801 no 2382 0.301846946595558 3390 3501 A protein kinase C inhibitor.
SGTC_2807 7945238 51.95 µM -0.519462639860593 0.293975078517083 no 2383 0.301719079689239 3373 17148797
SGTC_576 1073-0113 22.7 µM -0.519587448452195 0.293930631823766 no 2384 0.301675574090908 3501 5439563
SGTC_2350 9023895 38.85 µM -0.520126453403649 0.293738717694767 no 2385 0.301487720931532 3406 2997209
SGTC_1124 fisetin 1.16336 µM -0.522513923253165 0.292889350856755 no 2386 0.300656277413717 3340 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_453 enantio-paf c16 10 µM -0.522896345876594 0.292753406084339 no 2387 0.300523193817384 3403 13871343 A lipid and platelet activating factor
SGTC_1444 4112-3581 28 µM -0.523592530368483 0.292505999528158 no 2388 0.300280988985504 3392 2877249
SGTC_2634 4'-methoxyflavone 100 µM -0.52443508759835 0.292206705798236 no 2389 0.299987978674985 3342 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.525160372751447 0.291949183700461 no 2390 0.299735854931073 3419 5024745
SGTC_2833 9001315 45.46 µM -0.525306580987359 0.291897283332849 no 2391 0.299685041625427 3252 2989378
SGTC_2728 chlorpromazine 9.18 µM -0.526956512393637 0.291311895906363 no 2392 0.299111894081902 3371 2726 A thorazine and dopamine antagonist.
SGTC_1103 duloxetine 36.1 µM -0.528003004893981 0.290940889782639 no 2393 0.298748625170991 3446 60835 A selective serotonin reuptake inhibitor.
SGTC_726 3448-4391 34.2 µM -0.52937320710574 0.29045545506861 no 2394 0.29827329034075 3513 1356692
SGTC_693 4161-2696 114 µM -0.529680745602189 0.290346552567226 no 2395 0.298166649951529 3389 805759
SGTC_3000 9075062 71.4286 µM -0.529818923957365 0.290297628436002 no 2396 0.298118741625901 3313 17057871
SGTC_819 1013-0258 27.7 µM -0.530377706444311 0.290099822453912 no 2397 0.297925039870669 3358 5753198
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.533471340331191 0.289005837397667 no 2398 0.296853672502644 3402 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1173 0443-0020 122 µM -0.534069835618431 0.288794418996763 no 2399 0.296646609193763 3341 5331295
SGTC_2298 7976326 193.81 µM -0.534437137315401 0.288664705772669 no 2400 0.296519565427693 3346 2235818
SGTC_1016 4226-1401 38 µM -0.53789824618534 0.287443758876791 no 2401 0.295323649648066 3416 2901613
SGTC_2205 7238770 200 µM -0.540513676623587 0.28652275818063 no 2402 0.294421415840418 3437 279867
SGTC_2654 protoveratrine a 100 µM -0.541448836242092 0.28619379011204 no 2403 0.294099126952489 3367 5702278 A heart drug and vasodilator.
SGTC_1111 tnp00062 510.699 nM -0.543537874577906 0.285459562196265 no 2404 0.293379760476077 3478 676306
SGTC_19 0279-0214 38.434 µM -0.54483297004 0.285004829763691 no 2405 0.292934200342399 3455 3566274 YBR002C RER2
SGTC_602 3130-1533 38.1 µM -0.546401199765162 0.284454657559813 no 2406 0.292395092789946 3468 720941
SGTC_2429 5902844 64.44 µM -0.552193273200909 0.282427070294597 no 2407 0.290407971313021 3416 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1638 st008370 60.6 µM -0.554308787815173 0.281688245075003 no 2408 0.289683768584949 3450 24207134
SGTC_1352 1496-0991 99 µM -0.554546540175216 0.281605270398232 no 2409 0.289602431986896 3390 3000039
SGTC_2084 5306078 60.6385 µM -0.554601379208463 0.281586133455564 no 2410 0.289583672725826 3347 679340
SGTC_3261 9137475 49.47 µM -0.556207109966336 0.281026066705855 no 2411 0.289034639649587 3344 17027690
SGTC_1871 st057448 67.3 µM -0.556413378173604 0.280954160944484 no 2412 0.288964147720606 3552 691747
SGTC_902 1120-0002 2.07 µM -0.55688863940755 0.280788517202285 no 2413 0.288801758523284 3447 3280475
SGTC_1259 0671-0132 43 µM -0.556983887701689 0.280755325806452 no 2414 0.288769218865978 3337 X1259
SGTC_611 3453-1652 23.7 µM -0.557126268143228 0.28070571369936 no 2415 0.28872058068073 3470 1560575
SGTC_2149 5554786 194.827 µM -0.558166531595516 0.280343365240694 no 2416 0.288365336295529 3399 745063 YPR165W RHO1
SGTC_116 0155-0182 31.788 µM -0.558428719870973 0.280252074590949 no 2417 0.288275832932558 3394 771486
SGTC_2360 9040895 200 µM -0.558825392942332 0.28011398541208 no 2418 0.288140445327682 3390 4914414
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.559140920313723 0.280004168092408 no 2419 0.288032774808793 3496 368090
SGTC_106 0092-0003 11.579 µM -0.559621584803477 0.279836915962976 no 2420 0.287868789430427 3406 1072148
SGTC_912 3474-0017 2.18 µM -0.559677016889603 0.279817630918108 no 2421 0.28784988083894 3498 3360550
SGTC_1878 temozolomide 1 mM -0.560251575793275 0.279617777555406 no 2422 0.287653926028607 3466 5394 DNA alkylating agent.
SGTC_1515 3460-0031 42.1 µM -0.563336081774386 0.278546055489348 no 2423 0.286603026437071 3419 2876596
SGTC_1629 st005085 44.9 µM -0.563735384537988 0.278407462800729 no 2424 0.286467116133423 3378 24207091
SGTC_578 3460-0051 92 µM -0.564290040817046 0.27821500474503 no 2425 0.286278379061454 3512 2876744
SGTC_2289 7946404 165.07 µM -0.565519213154506 0.27778873027305 no 2426 0.285860329860749 3432 1246120 YPR165W RHO1
SGTC_1096 rimcazole 32.2 µM -0.565638817784 0.277747268662079 no 2427 0.285819667079684 3358 18528119 A dopamine reuptake inhibitor.
SGTC_2802 7925815 54.55 µM -0.566170917360969 0.277562850017755 no 2428 0.285638798996061 3391 1262923
SGTC_848 0368-0089 85.6 µM -0.566449539342406 0.277466307214535 no 2429 0.285544113220362 3461 762535
SGTC_133 0724-0033 378.92 µM -0.566479843275871 0.277455807860173 no 2430 0.285533815754162 3352 280309
SGTC_1067 clotrimazole 1.36 µM -0.567114574693947 0.277235938146291 no 2431 0.285318170683863 3425 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3139 9095020 49.47 µM -0.568526654312125 0.276747102468803 no 2432 0.284838706072378 3343 25236292
SGTC_3094 9117742 49.47 µM -0.569465971184469 0.276422162500538 no 2433 0.284519978759234 3436 17149698
SGTC_2622 2-methoxyxanthone 59.94 µM -0.571411020743096 0.275749902649774 no 2434 0.283860530142042 3417 71034 A hepatoprotective.
SGTC_2038 4100038 30.985 µM -0.572589934273397 0.275342830876777 no 2435 0.283461188334375 3466 3596803
SGTC_2409 alverine citrate 63.97 µM -0.573011340110646 0.275197393749288 no 2436 0.283318507882126 3560 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1276 0871-0068 94.2 µM -0.573303001567679 0.275096756630274 no 2437 0.283219776719329 3423 3414906
SGTC_488 nitrendipine 139 µM -0.573419633623392 0.275056518079873 no 2438 0.283180299885179 3479 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1162 k048-0130 20.1 µM -0.574150976059209 0.274804267963952 no 2439 0.282932820208964 3419 6797406
SGTC_1410 3909-8106 77.9 µM -0.576452910991816 0.274011043923825 no 2440 0.282154544783169 3486 1039210
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.576480816920653 0.274001434762551 no 2441 0.282145116220976 3501 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2914 7968218 45.32 µM -0.576933545456998 0.273845564942197 no 2442 0.281992174251799 3441 2977111
SGTC_2122 5258151 111.688 µM -0.578348880491531 0.273358562471818 no 2443 0.281514299687013 3409 2173356
SGTC_420 mitomycin C 81.9 mM -0.578740209179977 0.273223985953969 no 2444 0.281382240209327 3450 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2355 9061122 103.12 µM -0.579009303045165 0.273131464598189 no 2445 0.281291447977161 3453 5302957
SGTC_3299 9121982 43.1275 µM -0.581365568009257 0.272321984223786 no 2446 0.280497049190674 3441 17594604 YPL160W CDC60
SGTC_16 erodoxin 22.806 µM -0.581581756652689 0.272247773680173 no 2447 0.280424217073253 3526 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_496 calpeptin 138 µM -0.581923357656378 0.272130533633292 no 2448 0.280309153263165 3454 73364 A calpain inhibitor.
SGTC_109 0132-0036 33.701 µM -0.583137433164838 0.271714056963704 no 2449 0.279900393027537 3412 67274 A color developer.
SGTC_1715 st032160 10.2275 µM -0.585309655782832 0.270969689878502 no 2450 0.279169761743855 3449 5289825
SGTC_2188 6126565 140.678 µM -0.587880812350983 0.270089934788059 no 2451 0.278306148179749 3470 874518
SGTC_2484 5809818 12.04 µM -0.587912211366354 0.270079200039403 no 2452 0.278295609767964 3464 2870548
SGTC_2966 9084041 48.03 µM -0.588154105230199 0.269996508111743 no 2453 0.278214429759281 3322 17741380
SGTC_2320 7373003 200 µM -0.588342565059576 0.269932091503459 no 2454 0.278151190310794 3473 5415828
SGTC_398 bronopol 33.3 µM -0.588907068105271 0.269739187291841 no 2455 0.277961808024741 3435 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_255 tunicamycin 200.472 nM -0.589261749805048 0.269618019386941 no 2456 0.277842849843898 3452 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1001 4048-4355 44.4 µM -0.591496405686923 0.268855234215941 no 2457 0.277093931370087 3495 21824233
SGTC_679 0422-0091 41.4 µM -0.592280911140035 0.26858770565015 no 2458 0.276831248133836 3503 627384 YHR062C RPP1
SGTC_1304 1165-0502 251 µM -0.592293228920581 0.268583506162435 no 2459 0.276827124629902 3454 767425
SGTC_3302 9125395 16.351 µM -0.592511232005466 0.268509188065304 no 2460 0.276754150829529 3413 17599668
SGTC_862 0452-0056 10.2 µM -0.592613763467167 0.268474238267123 no 2461 0.276719832966571 3476 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1183 1254-0324 198 µM -0.592659660857564 0.268458594010045 no 2462 0.276704471524751 3527 5799357
SGTC_2749 bexarotene 57.39 µM -0.593489936526244 0.268175671332782 no 2463 0.276426657929992 3474 82146 An retinoic acid receptor inhibitor.
SGTC_2682 pyrogallin 40.03 µM -0.593527187629963 0.268162981256924 no 2464 0.276414196767156 3519 822798 An ATP competetive kinase inhibitor.
SGTC_1564 D-Arginine 115 µM -0.593618880501696 0.268131746167963 no 2465 0.276383525029447 3451 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_556 4058-0063 51.5 µM -0.59431735121164 0.267893872904868 no 2466 0.27614993778684 3505 6615692
SGTC_3253 9135987 49.47 µM -0.595086423620381 0.267632078319045 no 2467 0.275892851594325 3497 4182430
SGTC_622 1348-1566 26.3 µM -0.596081286697622 0.267293615313887 no 2468 0.275560462420478 3503 7340407
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.596793455976827 0.267051460459579 no 2469 0.275322643791732 3512 616764
SGTC_2617 dihydrotanshinone i 20.83 µM -0.597345470500776 0.26686383835226 no 2470 0.275138376045203 3495 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1350 1495-0454 146 µM -0.598036214415472 0.26662915788792 no 2471 0.27490788467172 3551 1069057
SGTC_2117 5521686 200 µM -0.598479255005458 0.26647868965227 no 2472 0.274760098462952 3488 803312
SGTC_2403 6032726 181.2 µM -0.601520104013363 0.265447097816044 no 2473 0.273746812814846 3482 2881040
SGTC_483 fpl-64176 144 µM -0.601574564930867 0.265428640727103 no 2474 0.273728681959479 3528 3423
SGTC_2256 7954252 200 µM -0.602357621700856 0.265163330721621 no 2475 0.273468056316844 3469 2972920
SGTC_1279 0874-0590 65.2 µM -0.60622951052436 0.263853465791953 no 2476 0.27218117955319 3484 3523074
SGTC_599 1935-0052 86.5 µM -0.608100848819458 0.263221574263364 no 2477 0.271560294654344 3493 9557311
SGTC_2236 dapsone 200 µM -0.60973124060247 0.262671673517571 no 2478 0.271019928137106 3549 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_658 3253-0951 102 µM -0.609990549428766 0.26258426769291 no 2479 0.270934033959957 3519 1184878
SGTC_1005 4092-0690 4.4 µM -0.610319531940531 0.262473398223337 no 2480 0.2708250804289 3479 1529343
SGTC_1548 st061468 90.8 µM -0.613491582949349 0.261405625140688 no 2481 0.269775673281152 3509 390799
SGTC_974 1326-0144 138 µM -0.615873081811929 0.260605435708723 no 2482 0.268989144372787 3531 5411856
SGTC_2791 5663188 71.43 µM -0.616117951051122 0.260523230593961 no 2483 0.268908337616648 3530 54690634
SGTC_2176 5809774 33.9695 µM -0.616409258329542 0.2604254531458 no 2484 0.268812222202602 3522 2870539
SGTC_3201 9113999 49.47 µM -0.616558966975911 0.260375210709947 no 2485 0.268762833278857 3534 16649224
SGTC_2275 7947463 200 µM -0.616786628873316 0.26029881662237 no 2486 0.26868773629338 3523 1225414
SGTC_2688 kanamycin b 96.69 µM -0.617840791214586 0.259945233148672 no 2487 0.268340145790496 3655 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1507 4075-3230 155 µM -0.621895091072446 0.258587666127586 no 2488 0.267005426601966 3496 659771
SGTC_2534 helenine 20.12 µM -0.622064269463362 0.258531097280391 no 2489 0.266949804211274 3549 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3216 9129716 49.47 µM -0.622367482078893 0.258429726919061 no 2490 0.266850128759346 3511 8056934
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.623892405589712 0.257920225246161 no 2491 0.266349124062983 3505 803109
SGTC_1988 st071872 53.4 µM -0.624538979624535 0.257704351814889 no 2492 0.266136839734387 3575 16414116
SGTC_871 0574-0004 149 µM -0.624808948790067 0.257614244242219 no 2493 0.266048228341706 3487 9551173
SGTC_2657 nystatin 74.44 µM -0.625626712141063 0.257341399347422 no 2494 0.265779906872176 3576 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3270 9137563 49.47 µM -0.625700755168227 0.25731670247513 no 2495 0.265755618923569 3500 17015724
SGTC_2313 7726885 200 µM -0.627103550292674 0.25684903640852 no 2496 0.265295680034331 3532 726423
SGTC_3066 9117245 49.47 µM -0.628225126853267 0.256475441904144 no 2497 0.26492823608362 3568 17176980
SGTC_749 1000-0129 128 µM -0.629280771083789 0.256124068110824 no 2498 0.264582628905103 3611 708470
SGTC_168 3970-0862 530.542 µM -0.630085352239185 0.255856429970141 no 2499 0.264319371334296 3584 3135186
SGTC_1998 st075797 76.8 µM -0.630975081806887 0.255560637863483 no 2500 0.264028408707207 3564 24208315
SGTC_2808 7946468 45.46 µM -0.631015388691128 0.255547242001989 no 2501 0.264015231267524 3544 2970879
SGTC_570 0987-0065 62.6 µM -0.63211062165327 0.255183385342716 no 2502 0.263657297525031 3459 3104428
SGTC_144 4161-2749 112.381 µM -0.63322097622306 0.254814781742331 no 2503 0.26329467475063 3503 797501 YMR168C CEP3
SGTC_949 1165-0505 146 µM -0.634657163922991 0.254338425278615 no 2504 0.262826018530084 3564 6244267
SGTC_824 1304-0008 100 µM -0.635185162168341 0.254163415609707 no 2505 0.262653829656131 3571 768245
SGTC_2237 6667747 47.222 µM -0.636597511707645 0.253695590510202 no 2506 0.262193523208769 3470 729940 YDL015C TSC13
SGTC_2664 lyso-paf C-16 73.48 µM -0.63690738620579 0.253593008548973 no 2507 0.262092585660199 3574 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1148 3909-7663 27.7 µM -0.639243782555937 0.252820261575885 no 2508 0.261332176918864 3638 4084526
SGTC_2648 atorvastatin 78.68 µM -0.639948724995023 0.252587350402869 no 2509 0.261102967535547 3590 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_999 SEC7.066 22.7 µM -0.639996149095466 0.25257168566067 no 2510 0.261087551478151 3583 740511 YDR170C SEC7
SGTC_3010 9080089 71.4286 µM -0.641299178318774 0.252141479966381 no 2511 0.260664161488706 3588 17027233
SGTC_2413 inermin 26.06 µM -0.643465509513273 0.251427104448202 no 2512 0.259961043906224 3658 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_411 enrofloxacin 100 µM -0.643673759065778 0.251358487887817 no 2513 0.259893504740615 3647 71188 A bacterial gyrase inhibitor.
SGTC_2521 angolensin 13.4 µM -0.646367423254284 0.250471839954275 no 2514 0.259020716286118 3598 821428 A flavenoid.
SGTC_2667 digitoxin 100 µM -0.64662404357647 0.250387457228007 no 2515 0.258937646525388 3556 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2365 9042475 200 µM -0.647234453353464 0.250186800872064 no 2516 0.258740108079385 3585 6464479
SGTC_2572 astragaloside iv 100 µM -0.647662274344064 0.250046216685339 no 2517 0.258601704814617 3607 45006101 An anti-inflammatory agent.
SGTC_88 0180-0332 8.668 µM -0.650203086943276 0.249212156897128 no 2518 0.257780523666088 3638 3101745
SGTC_102 gallobenzophenone 83.616 µM -0.650609793516492 0.249078786874389 no 2519 0.257649203393396 3640 70837
SGTC_177 1327-0068 8.361 µM -0.651049620642504 0.248934598478168 no 2520 0.257507228027546 3592 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2662 daunorubicin 22.37 µM -0.651722216583878 0.248714187487175 no 2521 0.257290193942855 3522 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1050 3232-1156 69.3 µM -0.652217038382653 0.24855209980427 no 2522 0.257130584961335 3540 700529
SGTC_293 4049-0273 38.5 µM -0.652302565229871 0.248524089669388 no 2523 0.257103002768667 3530 1380311
SGTC_1424 4048-1941 275 µM -0.652383855828594 0.248497468469502 no 2524 0.257076788181774 3646 X1424
SGTC_1155 4088-0394 48.2 µM -0.653962326426757 0.247980849260503 no 2525 0.256568038787994 3568 2326248
SGTC_2196 6573537 42.6665 µM -0.65398565029777 0.24797321986681 no 2526 0.256560525314902 3636 2903087
SGTC_1080 nisoldipine 24.4 µM -0.654707380946368 0.247737198878523 no 2527 0.256328086093034 3583 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2801 7907800 81.82 µM -0.6565401682391 0.247138378658505 no 2528 0.25573831568753 3618 6620925
SGTC_3088 9117578 49.47 µM -0.65693135767909 0.247010667020399 no 2529 0.255612527118251 3658 678341
SGTC_1222 0366-0074 1.18 µM -0.657171930386554 0.246932144773712 no 2530 0.255535186027009 3640 286520
SGTC_335 4077-0256 27.6 µM -0.657534161507857 0.246813938771089 no 2531 0.255418756355239 3622 3121989
SGTC_352 k048-0007 5.11 µM -0.657874867069652 0.246702784803091 no 2532 0.255309270813773 3588 6811911
SGTC_2096 5468907 200 µM -0.658721335878927 0.246426743459263 no 2533 0.255037364761962 3608 759785
SGTC_1798 st045719 60.953 µM -0.659821425405362 0.246068241532013 no 2534 0.254684216171413 3564 3980186
SGTC_1354 1498-1681 81 µM -0.661402329808484 0.245553539883036 no 2535 0.254177166104012 3645 5754243
SGTC_3309 9129340 25.759 µM -0.661660123030922 0.245469663943432 no 2536 0.254094533238939 3631 17158987
SGTC_2698 st077697 67.5 µM -0.6636495242938 0.244822907839038 no 2537 0.253457326173546 3565 3154499
SGTC_1256 0570-0116 285 µM -0.66643405640998 0.243919196548761 no 2538 0.252566850190628 3609 410638
SGTC_1402 3909-7673 35.9 µM -0.66718955018273 0.243674314174396 no 2539 0.252325532567948 3614 5328014
SGTC_1951 sophoraflavanone G 9.2 µM -0.668093341478441 0.24338153777432 no 2540 0.252037005944502 3637 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_59 0330-0160 1.33 µM -0.668241368009224 0.243333603814131 no 2541 0.251989766502511 3622 4293482
SGTC_1134 3477-0009 42.5 µM -0.668930673169688 0.243110460185622 no 2542 0.25176985132862 3672 3973534
SGTC_784 4579-0127 173 µM -0.669296880572826 0.242991955613768 no 2543 0.251653058147408 3676 1948547
SGTC_1239 0337-0584 35.4 µM -0.669917212260054 0.242791287838987 no 2544 0.251455283354454 3675 914301 YML130C ERO1
SGTC_188 3229-0966 278.469 µM -0.670450151062529 0.242618961971445 no 2545 0.251285436873277 3711 5722370
SGTC_1070 indatraline 8.81 µM -0.672796356517871 0.241861104157 no 2546 0.250538428013435 3612 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1978 st071761 42 µM -0.672924933347119 0.241819609163796 no 2547 0.25049752444278 3586 5147680
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.673030822287067 0.241785439026962 no 2548 0.250463841126023 3606 2333 A French combination drug.
SGTC_1394 3474-0001 65.7 µM -0.675051312580071 0.241133933372367 no 2549 0.249821582431218 3579 5017666 YIL048W NEO1
SGTC_2673 kobusone 100 µM -0.675098090375882 0.241118861217118 no 2550 0.249806723409821 3691 6710676 An epoxy ketone and protein crosslinker.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.675098972701967 0.241118576929984 no 2551 0.249806443142419 3590 4620898
SGTC_2339 9000433 200 µM -0.675612991592837 0.24095299005034 no 2552 0.249643195450957 3608 2988954
SGTC_2351 9026858 72.31 µM -0.676758593468591 0.240584166638861 no 2553 0.249279566763471 3588 1409300
SGTC_1123 mangostin 811.285 nM -0.677195930551317 0.240443448260187 no 2554 0.249140824691792 3612 5281650 An antioxidant.
SGTC_1002 4049-0206 172 µM -0.678437416723681 0.240044229759286 no 2555 0.248747195953058 3675 4662749
SGTC_1213 1315-0166 115 µM -0.679031178926444 0.239853424445489 no 2556 0.248559053342415 3613 768401
SGTC_2735 sertaconazole 140 nM -0.680972518948802 0.239230153240666 no 2557 0.247944439684509 3693 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3250 9135583 49.47 µM -0.682585607086103 0.238712941865423 no 2558 0.247434365700507 3657 7699353
SGTC_1781 st038725 66.3 µM -0.683163166930408 0.238527905227359 no 2559 0.247251872154383 3665 4270275 YIL048W NEO1
SGTC_2150 5556613 200 µM -0.683226092702729 0.238507750028904 no 2560 0.247231993632824 3657 743190
SGTC_1758 st042942 75.2445 µM -0.684072781604876 0.238236645274414 no 2561 0.246964604103165 3615 669317
SGTC_1901 st060216 58.6 µM -0.688073755815171 0.236957843701387 no 2562 0.245703168130643 3669 688792
SGTC_2378 9074213 121.43 µM -0.68853984676353 0.236809116294956 no 2563 0.245556443272603 3644 657714
SGTC_2070 5230947 200 µM -0.689708933010476 0.236436292385256 no 2564 0.245188623539788 3722 2835538
SGTC_1152 3909-8331 15.9 µM -0.691595057129014 0.235835485361785 no 2565 0.244595833322308 3647 16001939
SGTC_1645 Cervolide 78 µM -0.691849211760614 0.235754591201936 no 2566 0.244516014082371 3605 23173 A fragrance.
SGTC_2895 9054447 58.44 µM -0.691949185009609 0.235722775192314 no 2567 0.244484620551252 3704 2697450
SGTC_625 k213-0058 121 µM -0.692189778280036 0.235646217238307 no 2568 0.24440907851937 3721 3655420
SGTC_2331 7980721 200 µM -0.692681094956032 0.235489920479453 no 2569 0.24425485284838 3651 2981221
SGTC_258 haloperidol 50.781 µM -0.693836416509376 0.235122617214013 no 2570 0.243892401022231 3666 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2859 9028643 45.46 µM -0.694380606050388 0.234949716541492 no 2571 0.243721776433625 3629 17151580
SGTC_1497 4476-2978 41.3 µM -0.694384612050438 0.234948444010026 no 2572 0.243720520635769 3684 1528379
SGTC_694 1315-0438 43.2 µM -0.695288066587039 0.234661553216084 no 2573 0.243437395643324 3618 6793154
SGTC_2049 5262831 67.185 µM -0.695384526856786 0.234630933834718 no 2574 0.243407177382796 3698 763417
SGTC_1298 1079-1278 263 µM -0.69555564920798 0.234576619907521 no 2575 0.243353574601895 3701 2840950
SGTC_923 1900-2434 73.3 µM -0.695577796063114 0.234569591043726 no 2576 0.24334663773345 3654 5910570
SGTC_1314 1222-0010 41.1 µM -0.695834845265401 0.234488018510751 no 2577 0.243266132246882 3681 3526027
SGTC_2971 9092186 9.93 µM -0.697575148476819 0.233936160041866 no 2578 0.242721463878002 3655 25236400
SGTC_1457 k015-0032 57.3 µM -0.697581464722743 0.233934158441458 no 2579 0.242719488264958 3665 4302660
SGTC_725 1497-0963 19 µM -0.697606474732732 0.233926232933439 no 2580 0.242711665649644 3697 3549977
SGTC_68 0986-0284 82.829 µM -0.698255754902514 0.233720532378982 no 2581 0.24250863197395 3657 423278 YIL048W NEO1
SGTC_1384 3089-0840 101 µM -0.699543385235104 0.233312890797262 no 2582 0.242106254763325 3647 1069836
SGTC_1397 3532-0190 20.1 µM -0.700483561935932 0.233015496431813 no 2583 0.241812683664804 3604 5322280
SGTC_2333 9017922 200 µM -0.700629081514606 0.232969484859844 no 2584 0.241767262302701 3693 3163164
SGTC_2803 7707263 71.43 µM -0.70208738956194 0.23250866385815 no 2585 0.241312333055822 3677 2199229
SGTC_2141 5621638 7.665 µM -0.702208415597144 0.232470442782641 no 2586 0.241274599064403 3683 2856238
SGTC_2748 diazoxide 86.69 µM -0.703439176855427 0.232081956166047 no 2587 0.240891049460888 3629 3019 A potassium channel activatior.
SGTC_699 0375-0592 111 µM -0.704618472313061 0.231710053890329 no 2588 0.240523849844524 3711 762578
SGTC_2312 7706453 155.7 µM -0.704880226529411 0.231627552211976 no 2589 0.240442388256176 3724 976098
SGTC_1960 st011366 51.8 µM -0.705471465301331 0.23144126136041 no 2590 0.240258441762173 3698 3972846
SGTC_2946 9065502 71.43 µM -0.706805128979708 0.231021350000512 no 2591 0.23984379339136 3519 16489101
SGTC_1626 st003712 1.76 µM -0.707154265485538 0.23091149272498 no 2592 0.239735308132791 3644 24207035
SGTC_1946 st076057 65.1 µM -0.707763710887914 0.230719798070752 no 2593 0.239546002707745 3571 953009
SGTC_3038 9091290 49.47 µM -0.708428421648796 0.230510821671603 no 2594 0.239339623882375 3704 25236843
SGTC_1381 2324-0066 62.1 µM -0.710229694649087 0.229945057038817 no 2595 0.238780854709303 3697 10885928
SGTC_1455 4262-0120 131 µM -0.712395572630307 0.229265803398872 no 2596 0.238109928183704 3750 1529587
SGTC_1804 st050076 49.1 µM -0.713238954759468 0.229001610047915 no 2597 0.237848952463084 3716 3895976
SGTC_2679 rapamycin 1 nM -0.714080091419315 0.228738290316257 no 2598 0.237588827891305 3689 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1243 0416-0003 5.65 µM -0.717134804474199 0.227783436550698 no 2599 0.236645461063238 3723 2141977
SGTC_1947 st076332 61.6 µM -0.717328285261221 0.227723033230556 no 2600 0.236585779142625 3680 24208416
SGTC_623 k072-0108 16.9 µM -0.717350666218464 0.227716046637349 no 2601 0.23657887595017 3696 5382803
SGTC_13 0199-0087 65 µM -0.718874636127755 0.227240597642337 no 2602 0.236109082786035 3737 4589825
SGTC_517 1365-0151 113 µM -0.719709729122739 0.226980302312273 no 2603 0.235851867372014 3749 768657
SGTC_2694 st077685 81.9 µM -0.720793955064881 0.22664260418639 no 2604 0.235518147585207 3691 2838096
SGTC_2697 mebhydrolin 72.4 µM -0.721796489860244 0.226330602457014 no 2605 0.235209803933 3697 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2345 9052315 157.45 µM -0.722183175717418 0.226210325707366 no 2606 0.235090932866694 3729 6469265
SGTC_2843 9000894 45.46 µM -0.724083707973441 0.22561969965036 no 2607 0.234507173024979 3615 2242070
SGTC_2100 5377183 190 µM -0.726262369119649 0.224943714593105 no 2608 0.233838971896265 3752 2844202
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.726311131515526 0.224928597964998 no 2609 0.23382402842224 3739 688751
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.726577443365465 0.224846049893553 no 2610 0.233742425195522 3744 115019
SGTC_1210 3013-0140 750 nM -0.726921293129221 0.224739492982328 no 2611 0.233637086169175 3746 905973
SGTC_87 0100-0052 35.5 µM -0.728058612867296 0.224387248726585 no 2612 0.233288853692969 3788 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1966 st070145 16.1 µM -0.728768993801002 0.224167392634886 no 2613 0.233071490539082 3676 3748532
SGTC_2506 ethyl hematommate 54.16 µM -0.72930484365804 0.224001633213557 no 2614 0.232907605032877 3776 3940691 An allergen.
SGTC_1769 st044406 64.4 µM -0.731331823837291 0.223375238882041 no 2615 0.232288248356469 3738 670903
SGTC_2616 abietic acid 100 µM -0.731483410233567 0.223328434478977 no 2616 0.232241967026003 3717 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_530 4358-1714 28 µM -0.732015155246225 0.223164294961869 no 2617 0.232079658820665 3796 1564641
SGTC_1081 sertraline 6 µM -0.732611667203606 0.222980244891962 no 2618 0.231897656528552 3718 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1994 st072947 40.9 µM -0.732830734742679 0.222912674671261 no 2619 0.231830836600074 3765 5286565 YDL195W SEC31
SGTC_1156 4092-0367 4.88 µM -0.733488487972846 0.222709864279685 no 2620 0.231630273325386 3758 1357585
SGTC_2545 solidagenone 89.61 µM -0.736674149547448 0.22172909281914 no 2621 0.230660265380565 3559 6708572 An anti ulcer agent
SGTC_2302 7771753 200 µM -0.737092866794037 0.22160036583809 no 2622 0.230532938368641 3736 2203047
SGTC_399 oxolinic acid 75 µM -0.737651931455091 0.221428558206326 no 2623 0.230362994606302 3712 4628 A DNA gyrase inhibitor.
SGTC_2346 9031566 143.75 µM -0.738114444167205 0.221286479791159 no 2624 0.230222453543848 3722 4771086
SGTC_937 3122-0005 46.7 µM -0.738761235825556 0.221087880539107 no 2625 0.230025997154814 3749 759535
SGTC_2455 5377712 9.75 µM -0.739044330157924 0.221000987704495 no 2626 0.229940039655855 3722 2243908
SGTC_2361 9034121 116 µM -0.739478774688597 0.220867677536641 no 2627 0.22980816183216 3751 6496917
SGTC_903 1134-0042 114 µM -0.739873256658169 0.220746669852088 no 2628 0.229688451539678 3736 701009
SGTC_185 k048-0037 25.491 µM -0.740733765134225 0.220482839921389 no 2629 0.229427441134141 3751 6827589
SGTC_233 rapamycin 362 pM -0.741679754984101 0.220193010225862 no 2630 0.229140694344897 3738 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1653 st012112 65 µM -0.742274593569056 0.220010877203991 no 2631 0.22896049089685 3749 720429
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.742380559694339 0.21997844061639 no 2632 0.22892839732291 3763 229346 A bile salt which induces apoptosis.
SGTC_2873 9040596 71.43 µM -0.743247389938244 0.219713204011056 no 2633 0.228665958417757 3716 6463863
SGTC_810 3825-7150 143 µM -0.744747227266418 0.219254711034948 no 2634 0.228212271495925 3773 22330411 YGL099W LSG1
SGTC_3336 9143619 71.43 µM -0.744993757909323 0.219179400478038 no 2635 0.22813774671216 3767 45595730
SGTC_1522 st012842 45.6 µM -0.745091374477379 0.219149584530424 no 2636 0.228108241572097 3653 3491067 YOR116C RPO31
SGTC_485 niflumic acid 177 µM -0.745201114983618 0.219116068238721 no 2637 0.228075074467868 3782 4488 A COX2 inhibitor.
SGTC_1518 st038567 90.8 µM -0.745207229871635 0.219114200752742 no 2638 0.228073226432164 3732 77966
SGTC_2909 7941780 10.49 µM -0.745704994185945 0.218962214293752 no 2639 0.227922820815555 3727 1243215
SGTC_799 1310-0557 151 µM -0.746558814175385 0.218701651703721 no 2640 0.2276649585906 3798 5354492
SGTC_2761 levamisole 97.89 µM -0.749617189765924 0.21776978464934 no 2641 0.226742647415198 3736 26879 An alkaline phosphatase inhibitor.
SGTC_2778 tioconazole 65.09 nM -0.749903445074497 0.217682681906489 no 2642 0.226656429731974 3703 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_378 3970-0959 8.33 µM -0.750903642834618 0.217378496184859 no 2643 0.226355323922718 3774 6615653
SGTC_2954 9074818 52.69 µM -0.751020705942796 0.217342910350208 no 2644 0.226320097285048 3741 16648742
SGTC_1928 4'-methoxychalcone 40.3 µM -0.7516891720713 0.217139768818241 no 2645 0.22611900175604 3800 641818
SGTC_613 3914-0030 117 µM -0.751842964143219 0.217093048158816 no 2646 0.226072750581294 3513 1145395
SGTC_3085 9117376 49.47 µM -0.752048501227384 0.217030616895804 no 2647 0.226010946045935 3847 16480349
SGTC_2252 omeprazole 400 µM -0.755038866358101 0.216123476864906 no 2648 0.225112831119724 3694 4594 A proton pump inhibitor.
SGTC_1608 st001473 40.5 µM -0.756930062641445 0.215550909715633 no 2649 0.224545881747217 3733 7292267
SGTC_2941 9056145 11.23 µM -0.758621768569809 0.215039485268828 no 2650 0.224039423457266 3646 2119517
SGTC_1122 capsaicin 818.572 nM -0.759088117565504 0.214898625957234 no 2651 0.223899923356685 3867 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1329 1447-1697 50.6 µM -0.759401050381714 0.214804135596138 no 2652 0.22380634268915 3796 2840515
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.759675544062567 0.214721271844545 no 2653 0.223724275319331 3783 165506
SGTC_2277 7947813 106.88 µM -0.76099436982823 0.214323405749829 no 2654 0.22333021505173 3858 1246798
SGTC_1657 st012939 43.4 µM -0.761549725887199 0.214155993166521 no 2655 0.223164394970642 3775 24207257
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.761776709603947 0.214087590632464 no 2656 0.223096641592541 3597 88881 An O-methylated flavonoid and antioxidant.
SGTC_2940 9060638 45.86 µM -0.762404836975751 0.213898367996907 no 2657 0.222909210128442 3790 4027022
SGTC_3300 9124615 50.48 µM -0.764483077680001 0.213272994910662 no 2658 0.222289708671258 3799 24824903
SGTC_3344 9148862 3.898 µM -0.766045814261346 0.212803447619942 no 2659 0.221824521254719 3780 4905352
SGTC_3240 9133527 49.47 µM -0.767203172495027 0.212456091524933 no 2660 0.221480363483664 3742 17617455
SGTC_667 1498-1044 59 µM -0.767653838047461 0.212320923641516 no 2661 0.221346433962049 3792 6739982
SGTC_3134 9127454 49.47 µM -0.768463187368382 0.212078302136835 no 2662 0.221106026526168 3874 24262820
SGTC_2322 7413319 38.22 µM -0.769295038796521 0.211829104118451 no 2663 0.220859090879552 3848 1840400
SGTC_137 0438-0332 85.389 µM -0.771289572046718 0.211232299426692 no 2664 0.220267655976325 3795 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1706 st031321 9.9705 µM -0.773122465380172 0.210684730302992 no 2665 0.219724953417292 3822 6103185
SGTC_3334 9142812 21.919 µM -0.773234899054243 0.210651168348471 no 2666 0.219691687867749 3858 45283678
SGTC_1233 0325-0408 14.2 µM -0.776216558918361 0.209762274714042 no 2667 0.218810565276 3846 12874
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.776591681886182 0.209650599291572 no 2668 0.218699855331143 3852 5282309
SGTC_2712 st079126 47.7 µM -0.776929657150538 0.209550012819319 no 2669 0.218600136393373 3789 3152970
SGTC_832 4083-0019 164 µM -0.777492989908249 0.20938241970572 no 2670 0.218433984359106 3871 1990758
SGTC_3166 9102297 49.47 µM -0.779158229012977 0.208887467705243 no 2671 0.217943256339568 3786 25237072
SGTC_3115 9123671 49.47 µM -0.779256299893907 0.208858340019005 no 2672 0.217914375742781 3885 3286988
SGTC_2363 9053361 176 µM -0.779301618554454 0.208844880892013 no 2673 0.217901030733225 3834 6469797 YMR079W SEC14
SGTC_2885 9057732 51.95 µM -0.779631911976261 0.208746802936143 no 2674 0.217803783292829 3812 6471414
SGTC_1008 4106-0037 6 µM -0.780199688377118 0.208578269783354 no 2675 0.217636672868972 3752 2905394
SGTC_3338 9144300 39.5675 µM -0.780243914794795 0.208565145417784 no 2676 0.217623659063772 3832 4901274
SGTC_1819 st053448 58.6 µM -0.780963788454498 0.208351588511325 no 2677 0.21741189642992 3739 2857616
SGTC_866 0495-0101 262 µM -0.781856881149201 0.208086823996229 no 2678 0.217149344005246 3775 635694
SGTC_634 1611-4317 11.2 µM -0.782444041432244 0.207912863854315 no 2679 0.216976829792413 3809 2843522
SGTC_429 1112-0049 25.5 µM -0.784476321362061 0.207311416130154 no 2680 0.216380335285659 3772 2836170
SGTC_2939 9044578 71.43 µM -0.78462753961094 0.20726670466016 no 2681 0.216335989186427 3781 2653634
SGTC_2932 9016711 44.54 µM -0.785869260642888 0.206899774393957 no 2682 0.215972042444872 3805 7117328
SGTC_3269 9137823 49.47 µM -0.785914628707968 0.206886375352651 no 2683 0.215958751847276 3740 17682936
SGTC_1417 3966-0327 90.4 µM -0.786550908675745 0.206698510026493 no 2684 0.215772403241442 3868 651118
SGTC_2921 7974240 10.71 µM -0.787332617552111 0.206467844314648 no 2685 0.215543590218073 3881 2979074 YDR527W RBA50
SGTC_566 0958-0068 16.5 µM -0.788482244773832 0.206128890900467 no 2686 0.215207340060459 3759 6815365
SGTC_3002 9075603 71.4286 µM -0.788709611213208 0.206061893807621 no 2687 0.215140874582563 3786 20105405
SGTC_60 0986-0278 202 µM -0.788742059034569 0.206052333600392 no 2688 0.215131390161658 3681 3110598
SGTC_1345 1488-0192 31.4 µM -0.791277700736021 0.205306062915106 no 2689 0.214390979054908 3816 658348
SGTC_629 3448-6466 76.7 µM -0.793668540913831 0.20460388188551 no 2690 0.213694209538525 3820 573744
SGTC_528 3492-0019 172 µM -0.794168790937908 0.204457141254104 no 2691 0.213548587270983 3835 2869262
SGTC_2321 7390090 138.78 µM -0.796444815724801 0.203790295710129 no 2692 0.21288676925521 3842 649046
SGTC_1084 voriconazole 435 nM -0.796871126183852 0.203665536627906 no 2693 0.212762940777887 3816 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1322 1348-1070 12 µM -0.797413159837653 0.20350697711489 no 2694 0.212605559441326 3777 6758089
SGTC_2820 7989630 71.43 µM -0.797640631579591 0.203440457414382 no 2695 0.212539532496692 3738 2984098
SGTC_2144 5628481 200 µM -0.79782180553548 0.203387485884792 no 2696 0.212486952720133 3823 2818399
SGTC_2518 prenyletin 46.28 µM -0.798626707644522 0.20315224861427 no 2697 0.212253448268568 3782 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_548 1436-0017 110 µM -0.799234939940385 0.202974597014398 no 2698 0.212077097836775 3888 9677137
SGTC_3182 9108849 49.47 µM -0.800243881351894 0.202680111559164 no 2699 0.211784755108252 3852 17133045
SGTC_1752 st044819 83.042 µM -0.801632531791351 0.202275216088353 no 2700 0.211382776819033 3840 441209 YML126C ERG13
SGTC_2658 polymyxin b sulfate 77.05 µM -0.802207912753857 0.202107591367765 no 2701 0.211216349980386 3850 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3165 9101544 49.47 µM -0.803213960024754 0.201814701197281 no 2702 0.210925539040006 3856 5002184
SGTC_729 4092-0585 94.1 µM -0.803280407750311 0.201795365247175 no 2703 0.21090633973647 3834 2169061
SGTC_2458 5808907 16.39 µM -0.804501610598852 0.201440199009416 no 2704 0.210553669776876 3923 2731747
SGTC_8 0354-0001 70 µM -0.805108660458927 0.201263788284678 no 2705 0.210378489300201 3843 4993152
SGTC_1875 nocodazole 6 µM -0.805540183632188 0.201138442543928 no 2706 0.210254013793311 3804 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_600 1495-0418 41.6 µM -0.805782067814725 0.201068202250272 no 2707 0.210184259737403 3827 5377768
SGTC_1487 3970-0795 2.82 µM -0.805803099450169 0.201062095608441 no 2708 0.210178195320619 3893 3765103
SGTC_1501 4491-0275 38.4 µM -0.806050464498161 0.200990280263225 no 2709 0.210106875972722 3782 5104718
SGTC_884 0851-0618 334 µM -0.80641267245348 0.200885151341422 no 2710 0.210002471209101 3881 9642473
SGTC_1341 1486-1360 280 µM -0.806919714035256 0.20073804067008 no 2711 0.209856370042312 3801 3976547
SGTC_2175 5807670 165.306 µM -0.808841159126 0.200181148687502 no 2712 0.209303258963713 3819 241186
SGTC_3213 9129884 49.47 µM -0.810599146319038 0.199672445934907 no 2713 0.208797953637545 3846 17190742
SGTC_2078 5212016 200 µM -0.811719202308699 0.199348745184344 no 2714 0.208476386676265 3745 1899708
SGTC_2800 7887935 81.82 µM -0.812298820885386 0.199181357188771 no 2715 0.208310093491236 3872 2961002
SGTC_208 k072-0098 12.366 µM -0.813209071510023 0.19891865693217 no 2716 0.20804909961618 3823 5948901
SGTC_692 k241-0027 77.8 µM -0.813816917234357 0.198743347709431 no 2717 0.207874921074894 3878 3600480
SGTC_2258 7960471 200 µM -0.815274265377081 0.198323412467851 no 2718 0.207457668013574 3884 2974708
SGTC_3327 9140648 26.9345 µM -0.815428476359538 0.198279007885085 no 2719 0.20741354487989 3871 8029710
SGTC_340 k038-0059 454 µM -0.816281668638027 0.198033442226567 no 2720 0.207169528185279 3844 23733424
SGTC_1283 0922-0125 16.4 µM -0.816909544615981 0.197852844435482 no 2721 0.206990061439843 3866 3360884
SGTC_3186 9110464 49.47 µM -0.818018884783398 0.197534005003054 no 2722 0.206673202004973 3843 17018021
SGTC_945 3381-0768 11.3 µM -0.818354926579384 0.197437483360782 no 2723 0.20657727552121 3913 1126236 YIL048W NEO1
SGTC_3014 9081533 49.47 µM -0.818706241906178 0.197336605185694 no 2724 0.206477017257527 3889 21367265
SGTC_1553 gossypol 38.6 µM -0.819101619892253 0.197223111964092 no 2725 0.206364218889091 3732 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2327 6189656 200 µM -0.820614632034357 0.196789166767687 no 2726 0.205932905260892 3941 5349088
SGTC_2784 7567673 72.73 µM -0.820620707587969 0.196787425411822 no 2727 0.205931174384437 3846 3471247
SGTC_670 4204-0025 119 µM -0.821341874717427 0.196580793078112 no 2728 0.205725780970535 3871 719039
SGTC_3068 9116768 49.47 µM -0.82173931029702 0.196466974096362 no 2729 0.205612640533902 3818 41904888
SGTC_199 4063-0024 41.6 µM -0.823401754607755 0.195991310582606 no 2730 0.205139782802584 3874 306215
SGTC_730 1436-0052 41.2 µM -0.823947287207595 0.195835373541472 no 2731 0.204984755046951 3882 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1730 st033808 45.1 µM -0.825162532889229 0.19548827403172 no 2732 0.204639660789508 3834 1045166
SGTC_417 st075190 100 µM -0.825315522339028 0.195444603548798 no 2733 0.204596240766099 3857 222757
SGTC_2908 7930301 100 µM -0.827418155354432 0.194845012352772 no 2734 0.204000046843635 3879 2223178
SGTC_2786 7743617 45.45 µM -0.827452140113012 0.194835330384636 no 2735 0.203990419097502 3830 583674
SGTC_2841 9004761 38.96 µM -0.82862887202062 0.194500269986665 no 2736 0.203657222661455 3889 2991039
SGTC_1795 st049545 62.3 µM -0.829008896716377 0.194392137443583 no 2737 0.203549686483205 3807 5291882
SGTC_96 0929-0093 37.281 µM -0.831175714524693 0.193776288835849 no 2738 0.202937186012751 3850 6991579
SGTC_1776 st049249 45.9 µM -0.831604424269448 0.193654582905694 no 2739 0.202816131998474 3934 1822314
SGTC_1792 st045773 43.6 µM -0.831691521080667 0.19362986278734 no 2740 0.202791543899015 3793 2919270
SGTC_2425 5628681 7.85 µM -0.832129000861719 0.193505724872038 no 2741 0.202668066934913 3958 5714958
SGTC_2823 7987624 58.44 µM -0.832999458872846 0.193258870822367 no 2742 0.202422517232301 3871 2239440
SGTC_1176 0848-0131 83.3 µM -0.834588213077406 0.192808810252976 no 2743 0.201974800462042 3935 6769040
SGTC_1547 harmine 94.2 µM -0.835414892393447 0.192574882907246 no 2744 0.201742073829547 3880 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2444 5485484 36.41 µM -0.835870645346205 0.192445991661508 no 2745 0.201613839032172 3965 6790631
SGTC_402 epigallocatechin gallate 10 µM -0.835962590890907 0.192419994987033 no 2746 0.201587974317632 3847 65064 An antioxidant.
SGTC_1636 st007707 68.9 µM -0.836564460171076 0.192249875561454 no 2747 0.201418714756844 3898 403051
SGTC_1058 3448-5425 97.3 µM -0.839989976274372 0.191283400209434 no 2748 0.200457003361722 3773 7279705
SGTC_2116 5511452 16.8835 µM -0.840992270141151 0.191001177099696 no 2749 0.200176132412255 3949 870744
SGTC_2332 7982454 138.89 µM -0.841682464476146 0.190806982670457 no 2750 0.199982858120446 3847 2981748
SGTC_2082 5219693 150 µM -0.845363328553938 0.189773374802398 no 2751 0.198954006350608 3883 2834649
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.848108012388111 0.189004897270276 no 2752 0.198188909904953 3919 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3090 9117696 49.47 µM -0.848129390050216 0.188998919322563 no 2753 0.198182957737976 3847 7923821
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.850953746560737 0.188210154153172 no 2754 0.197397523471981 3941 94937 An inhibitor of serotonin biosynthesis.
SGTC_2587 piperic acid 92.2 µM -0.85097750823301 0.188203526799146 no 2755 0.197390923508663 3926 5370536
SGTC_1643 st009866 20.2 µM -0.851222317708 0.188135255517238 no 2756 0.197322933810908 3876 3156273 YOR207C RET1
SGTC_1167 k781-0610 148 µM -0.851372160404861 0.188093475652515 no 2757 0.197281325745512 3917 4525169
SGTC_2588 indole-3-carbinol 100 µM -0.851536792931211 0.188047578618981 no 2758 0.197235616984767 3959 3712 Induces cell cycle arrest.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.853626985645265 0.187465466020078 no 2759 0.196655850722342 3909 91467 include heat shock
SGTC_1288 0973-0013 65.5 µM -0.855251362047034 0.187013851849465 no 2760 0.196206003709017 3951 4315430
SGTC_1474 0330-0125 5.35 µM -0.857452816697174 0.186402871836459 no 2761 0.195597340198017 3905 X1474
SGTC_1997 st073024 93.8 µM -0.858993467428475 0.185976024169267 no 2762 0.195172060051985 3921 686268
SGTC_508 roscovitine 141 µM -0.859817047435643 0.185748094556181 no 2763 0.194944950283755 3973 160355 A CDKinase inhibitor.
SGTC_3237 9133362 49.47 µM -0.861094901615166 0.185394785635924 no 2764 0.194592888481428 3846 43845137
SGTC_857 0438-0306 1.35 µM -0.862710216024525 0.184948771092561 no 2765 0.194148407029642 3995 4686136
SGTC_1948 st076329 66.6 µM -0.862869925042849 0.184904709087887 no 2766 0.19410449397546 3796 24208413
SGTC_1305 1181-0477 144 µM -0.865764554315375 0.184107242834351 no 2767 0.193309645454332 3977 6252086
SGTC_542 3381-0244 89.3 µM -0.8745219005253 0.181707669903074 no 2768 0.190917049409576 3973 1112843
SGTC_1272 0839-0021 27 µM -0.875759716472521 0.181370085189348 no 2769 0.190580336890476 3956 5027250
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.876083764832616 0.181281773642563 no 2770 0.190492249025489 3964 6708784 An antioxidant flavonoid
SGTC_2406 ethylparaben 405.7 µM -0.876578248805079 0.181147065896757 no 2771 0.190357878891424 3989 8434 A possible steroid mimic.
SGTC_3312 9133330 71.43 µM -0.878501884076326 0.180623624176671 no 2772 0.18983570785378 3990 17617324
SGTC_98 0074-0023 107.663 µM -0.878975394497101 0.180494922548352 no 2773 0.189707308599052 3947 3563821
SGTC_3153 9100258 49.47 µM -0.878993405170587 0.180490028326276 no 2774 0.189702425797065 3864 25236848
SGTC_2799 7812892 81.82 µM -0.879027230891883 0.180480836746633 no 2775 0.189693255649344 3972 20205235
SGTC_3020 9089140 49.47 µM -0.880001905500892 0.180216111196722 no 2776 0.189429138645605 4007 17217859
SGTC_2835 9006588 71.43 µM -0.880389729449005 0.180110844462718 no 2777 0.189324109212989 4028 2345538
SGTC_2512 diallyl trisulfide 49.23 µM -0.882390632114621 0.179568354613539 no 2778 0.188782799934536 3973 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1308 1187-1617 41.4 µM -0.884880200757331 0.178894811791924 no 2779 0.188110623824838 3947 2882570
SGTC_865 0488-0499 301 µM -0.88524377562398 0.17879658129728 no 2780 0.188012583454073 3942 9634651
SGTC_1961 st076550 68.7 µM -0.886788117026441 0.17837971035325 no 2781 0.187596493222906 3999 1579337
SGTC_303 1348-1668 34.2 µM -0.886850882766151 0.178362780678024 no 2782 0.187579594358366 3956 5380509
SGTC_72 0744-0168 198.391 µM -0.886994095655576 0.178324155947259 no 2783 0.187541039659757 3860 677577
SGTC_2066 5222451 176 µM -0.889430441404931 0.177667877515252 no 2784 0.186885895403728 3924 2281147
SGTC_527 4476-4215 268 µM -0.889821889626629 0.177562575390292 no 2785 0.186780765437457 3931 4418754
SGTC_1014 4130-3005 69.3 µM -0.891744462330561 0.177045962771913 no 2786 0.186264957944739 3973 743608
SGTC_366 0181-0206 4.31 µM -0.892984756373639 0.176713189030497 no 2787 0.185932667999198 3931 274874
SGTC_1609 st001574 46.4 µM -0.89310027505562 0.176682215246394 no 2788 0.185901737854501 3944 3960012
SGTC_644 1498-1197 63.3 µM -0.893646670469664 0.176535757899516 no 2789 0.185755483640621 4008 6741615
SGTC_1137 ixabepilone 100 µM -0.893953163402149 0.176453638306335 no 2790 0.185673475623145 3921 154225 A novel microtubule stabilizer.
SGTC_728 3030-5151 22.5 µM -0.894819239144565 0.176221718613582 no 2791 0.185441862017765 3993 3125388
SGTC_564 3555-0129 330 µM -0.894894860778839 0.176201477645455 no 2792 0.185421647130895 3810 563260
SGTC_1774 st048371 48.465 µM -0.896776899248051 0.175698203271762 no 2793 0.184918988518729 3929 4242727
SGTC_521 r062-0005 13.8 µM -0.905199786954008 0.173457019488472 no 2794 0.182679777364364 3878 2832033
SGTC_1799 st045822 46.1415 µM -0.905744699364547 0.1733126571745 no 2795 0.182535498708455 3922 3674992
SGTC_742 0kpi-0133 140 µM -0.9060234503923 0.17323883792909 no 2796 0.182461720198408 4037 2728852
SGTC_2927 9011802 47.9 µM -0.910889652275766 0.171953390076363 no 2797 0.181176759190719 4009 43912568
SGTC_3342 9147791 14.508 µM -0.912111157586187 0.171631677863818 no 2798 0.180855102692528 3898 1838168
SGTC_1762 st045503 25.4615 µM -0.913084993083385 0.17137547100973 no 2799 0.180598921178611 4071 4645554
SGTC_1854 st056233 32.9 µM -0.913402152997289 0.17129208205639 no 2800 0.180515536827 3875 5393174
SGTC_1380 2291-0730 164 µM -0.915350571651862 0.170780365358481 no 2801 0.180003809074066 4028 2999191
SGTC_2022 5136654 200 µM -0.91558007572335 0.170720154763449 no 2802 0.179943592727263 4048 1713771
SGTC_501 nsc-95397 161 µM -0.91613377809002 0.17057494640202 no 2803 0.179798366631729 4050 262093
SGTC_1170 0310-0127 64.8 µM -0.917338856008541 0.170259188325881 no 2804 0.179482551117885 4010 774975
SGTC_2747 doxorubicin 7.63 µM -0.919578781357963 0.16967327208485 no 2805 0.178896459599896 3920 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1151 3909-8316 15.3 µM -0.92198538481085 0.169045199497097 no 2806 0.178268099578569 4043 800431
SGTC_371 0195-0006 7.36 µM -0.92249245283446 0.168913056159447 no 2807 0.178135882604384 3847 3928593
SGTC_2299 7976368 114.88 µM -0.922859465617887 0.168817453015995 no 2808 0.178040223327139 4043 2979718
SGTC_1422 4031-0024 15.5 µM -0.925878600692417 0.168032318426839 no 2809 0.1772545366943 3955 782427
SGTC_1191 1487-1166 10.6 µM -0.928771225267353 0.167282291221558 no 2810 0.176503829868406 4043 3955771
SGTC_1969 st069479 40.1 µM -0.928909109695992 0.167246593197314 no 2811 0.176468095772551 4023 3895485
SGTC_1040 k898-0338 155 µM -0.929774333261152 0.167022700503451 no 2812 0.176243969104304 4010 20969351
SGTC_1255 0566-0045 221 µM -0.931005815530521 0.166704365047434 no 2813 0.175925277960382 4052 2788469
SGTC_1126 isoteolin 1.0172 µM -0.933595123734003 0.166036312493658 no 2814 0.17525639080889 3951 133323
SGTC_3235 9132602 49.47 µM -0.934761415842689 0.165735970006674 no 2815 0.174955634059257 4024 4912240
SGTC_768 0384-0033 77.3 µM -0.935722649655448 0.165488698162912 no 2816 0.174708002916116 4006 3965305 YMR134W ERG29
SGTC_1472 k841-0093 193 µM -0.936182965860534 0.165370369025924 no 2817 0.174589496003615 4103 X1472
SGTC_319 1348-1596 45.5 µM -0.938153510450233 0.164864438696034 no 2818 0.17408276286115 4121 5380505
SGTC_1236 0330-0013 258 µM -0.939370155032024 0.164552570597968 no 2819 0.173770365310983 4028 4617066
SGTC_3206 9114350 49.47 µM -0.943159178772563 0.163583763913267 no 2820 0.172799744878003 3940 17087243
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.944852591345904 0.163151979146981 no 2821 0.172367068979962 4025 688662
SGTC_2888 9058547 12.99 µM -0.946561738911804 0.162716934013979 no 2822 0.171931074118091 3933 16476514
SGTC_1682 st012968 530 nM -0.947729589898684 0.162420104440611 no 2823 0.171633566574382 4035 24207270
SGTC_970 1315-0089 19.5 µM -0.947859446183218 0.162387120999612 no 2824 0.171600506293851 3962 6811083 YLR033W RSC58
SGTC_1814 st052110 31.539 µM -0.949190692678763 0.162049236414437 no 2825 0.171261817202222 3973 674163
SGTC_3046 9092212 49.47 µM -0.949217490469739 0.162042439553598 no 2826 0.171255003833157 4085 25236637
SGTC_1719 st032227 49.2 µM -0.950736101998159 0.161657569755175 no 2827 0.170869178319943 4041 3125804
SGTC_2556 citropten 84.59 µM -0.951075664453156 0.161571594211021 no 2828 0.17078298364857 4064 2775 A potential DNA crosslinker.
SGTC_3205 9113483 49.47 µM -0.951960931134779 0.16134758922804 no 2829 0.170558398062786 4100 17018033
SGTC_211 3455-0679 143.504 µM -0.952315898768174 0.161257826299578 no 2830 0.170468398546342 4080 748649
SGTC_3189 9110682 49.47 µM -0.953265472586768 0.161017861677134 no 2831 0.170227790393144 4136 17122418
SGTC_2770 toltrazuril 17.5 µM -0.954870947962861 0.160612676055443 no 2832 0.169821481553818 3936 68591 Kills coccidiodes.
SGTC_2135 5326629 150.42 µM -0.955228339011143 0.16052256935352 no 2833 0.169731118805061 4004 5020077
SGTC_1116 jasmonic acid 1.58368 µM -0.956524455581777 0.160196064943362 no 2834 0.169403667473981 4106 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2475 5812728 15.03 µM -0.957532921305538 0.159942323097674 no 2835 0.169149168990425 3997 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1851 st056236 18.9 µM -0.957715807249128 0.159896335014497 no 2836 0.169103041829314 4031 5393171
SGTC_23 0213-0011 39.996 µM -0.959117542314378 0.159544145118444 no 2837 0.168749767009839 4047 627608
SGTC_2469 5655019 90.81 µM -0.961266941721055 0.15900508940968 no 2838 0.168208982642737 4103 2788239
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.963488810053563 0.158449114833462 no 2839 0.167651138518697 4014 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2306 7482397 179.52 µM -0.966157564613633 0.157783004327081 no 2840 0.166982671712909 4063 891448
SGTC_1922 5578187 25 µM -0.967514473637193 0.157445031568923 no 2841 0.166643454674738 4084 1350412
SGTC_1746 st038117 42 µM -0.969686743983581 0.15690496358742 no 2842 0.166101329986476 4114 2898218
SGTC_2260 7964312 200 µM -0.969740347498533 0.156891652155327 no 2843 0.166087966796239 4131 231951
SGTC_621 3584-0052 32.1 µM -0.971561752656907 0.156439781768414 no 2844 0.165634308948072 4062 2273927
SGTC_3104 9120930 49.47 µM -0.972580732663021 0.156187358371938 no 2845 0.165380861213642 4091 17014836
SGTC_2942 9052777 62.25 µM -0.974683416039214 0.155667326861842 no 2846 0.164858660848598 4117 6469503
SGTC_1079 idarubicin 2.36 µM -0.974937627560416 0.155604533232961 no 2847 0.164795599983602 4068 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_257 daunorubicin 18.5 µM -0.977015464271593 0.155091906375452 no 2848 0.164280748263054 4084 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2491 paeonol 100 µM -0.979095080048516 0.154579958334423 no 2849 0.16376650119132 3942 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1031 k035-0009 16 µM -0.982222695441011 0.153812124974458 no 2850 0.162995074488004 4134 5180959
SGTC_2029 5175081 200 µM -0.984625578879112 0.153223931886227 no 2851 0.162404010270922 4039 1380876
SGTC_3199 9111318 49.47 µM -0.988283921664594 0.152331285214196 no 2852 0.161506808750185 4028 8548020
SGTC_2968 9090663 33.37 µM -0.990377647886492 0.151821965942095 no 2853 0.160994783264325 4041 25236811
SGTC_1089 terbinafine 2.25 µM -0.991252022690255 0.151609601082414 no 2854 0.160781266880642 4086 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1900 st060200 72.8 µM -0.99129436408073 0.151599322379754 no 2855 0.160770932096563 4068 688945
SGTC_529 4076-0302 30.3 µM -0.992662319265401 0.151267489832715 no 2856 0.160437271837026 4036 5816522
SGTC_1139 k015-0024 46.9 µM -0.993192570465917 0.151138993860256 no 2857 0.160308059138962 4111 2766652
SGTC_2006 4011487 200 µM -0.99781581867684 0.150021717934569 no 2858 0.159184339046827 4132 45595294
SGTC_2689 tacrolimus 100 µM -0.998793669873824 0.14978611317054 no 2859 0.15894732656787 4114 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_3212 9128307 49.47 µM -0.999272971278765 0.149670719841442 no 2860 0.1588312375472 4044 27243542
SGTC_2482 5981709 142.65 µM -1.00010847844645 0.149469710694517 no 2861 0.158629006746878 4043 877755
SGTC_965 1291-5240 308 µM -1.00423983837973 0.148478423332793 no 2862 0.157631512020995 4114 2834598
SGTC_1602 st001878 87.6 µM -1.00687360430062 0.147848771757879 no 2863 0.156997759001013 4113 595405 YLR310C CDC25
SGTC_1332 1480-0653 17.5 µM -1.01093443531039 0.146881461184565 no 2864 0.156023905646406 4097 5749438
SGTC_339 3091-4833 71.4 µM -1.01206667174418 0.146612515225761 no 2865 0.155753088221809 3977 3240077
SGTC_1194 1488-0194 225 µM -1.016830850504 0.145484477952779 no 2866 0.15461695166255 4052 1391452
SGTC_3285 9112818 20.8695 µM -1.01717654553479 0.145402853846118 no 2867 0.154534725775626 4079 17017947 YPR165W RHO1
SGTC_2642 cholecalciferol 100 µM -1.02261714790862 0.144122298150664 no 2868 0.153244449306445 4108 9821465 A vitamin D precursor, similar to steriods.
SGTC_2741 miltefosine 3.04 µM -1.02311529640948 0.144005430014709 no 2869 0.153126667709029 4088 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2296 7971656 126.45 µM -1.02521540923296 0.143513435857161 no 2870 0.152630779513757 4166 666570
SGTC_1117 retinoic acid 1.10837 µM -1.02616897229615 0.14329041931435 no 2871 0.152405971943008 4164 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_262 fenpropimorph 62.5 µM -1.02628333871459 0.143263687357647 no 2872 0.152379024217517 4080 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_584 0986-0246 15.4 µM -1.02634114692813 0.143250176572633 no 2873 0.15236540429073 4204 53315 YDR232W HEM1
SGTC_817 1391-0715 46 µM -1.02657611768278 0.143195268678111 no 2874 0.152310052231453 4118 1353946
SGTC_403 arphamenine a 50 µM -1.02726889029484 0.143033464536371 no 2875 0.152146933495424 4080 5487158 An arginine aminopeptidase inhibitor.
SGTC_2465 5809242 33.21 µM -1.0285596262038 0.142732329539493 no 2876 0.151843329132416 4165 2731748
SGTC_933 2914-0560 114 µM -1.02918568675133 0.142586421027891 no 2877 0.151696213471871 4170 463887
SGTC_2395 5646831 180.19 µM -1.0369126802516 0.140793886942206 no 2878 0.149888276909881 4162 6808628
SGTC_777 1315-0167 517 µM -1.04060423951467 0.139942926963848 no 2879 0.149029631403578 4149 4221767
SGTC_510 ag-490 170 µM -1.04237947206094 0.139534956254721 no 2880 0.148617889979691 4249 5328779
SGTC_77 0828-0286 12.516 µM -1.0446428093621 0.139015987076311 no 2881 0.148094043103633 4056 745345
SGTC_2329 6138490 200 µM -1.04817660582825 0.138208339833626 no 2882 0.147278623414813 4258 720019
SGTC_1430 4049-0248 69.1 µM -1.05123553282685 0.137511811769762 no 2883 0.146575213672737 4156 22774488
SGTC_1704 st028805 70.8 µM -1.05261663121921 0.137198117550259 no 2884 0.146258365841083 4182 2876101
SGTC_2048 5246248 200 µM -1.05278187986016 0.137160616755571 no 2885 0.146220485780785 4170 677046
SGTC_1229 0139-0193 12.2 µM -1.05417112510371 0.13684562447719 no 2886 0.145902288683558 4232 3090752
SGTC_230 MPP+ 141.667 µM -1.05518590929673 0.136615848832504 no 2887 0.145670153628666 4135 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2223 6903751 107.57 µM -1.05602318229721 0.136426465451884 no 2888 0.145478811863721 4131 5598863
SGTC_2254 7938975 95.19 µM -1.05612369638916 0.13640374217686 no 2889 0.145455852775746 4244 2969277
SGTC_3184 9108758 49.47 µM -1.05620162292228 0.136386127065302 no 2890 0.14543805473849 4166 902885
SGTC_1510 1123-0200 71.5 µM -1.05684611304228 0.136240501231233 no 2891 0.145290912515915 4200 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2257 7960413 200 µM -1.05749970140136 0.136092928305059 no 2892 0.145141795412845 4170 2974689 YIL048W NEO1
SGTC_1446 4239-0190 62 µM -1.05774083594556 0.136038510467392 no 2893 0.145086806245793 4164 1340085
SGTC_4 0960-0234 25.671 µM -1.05859983270505 0.135844778140844 no 2894 0.144891031568591 4158 6821112
SGTC_196 k015-0023 18.111 µM -1.0590025722989 0.135754012059518 no 2895 0.14479930412059 4087 5211998
SGTC_2539 epi(13)torulosol 80 µM -1.05934678959435 0.135676468173322 no 2896 0.144720936636638 4178 6708597
SGTC_2037 5169046 200 µM -1.06096830270604 0.135311588385618 no 2897 0.14435215323624 4223 5718022
SGTC_2315 7733312 200 µM -1.06147337837657 0.135198071622025 no 2898 0.1442374125256 4051 726316
SGTC_3278 9139605 49.47 µM -1.06582189588038 0.134223434655637 no 2899 0.143252080481899 4179 7958859
SGTC_1824 st053723 68.6 µM -1.06688879100023 0.133985049626892 no 2900 0.143011028508836 4194 675225
SGTC_656 4090-1979 187 µM -1.06785557834756 0.13376928388987 no 2901 0.14279283150468 4212 22330961
SGTC_1142 3253-1408 9.78 µM -1.069390286945 0.133427261340607 no 2902 0.142446921099197 4181 256655
SGTC_194 1486-1323 56.904 µM -1.06939584911568 0.133426022859681 no 2903 0.142445668464436 4232 5178754
SGTC_2488 5268135 45.7 µM -1.07002672112763 0.133285603298471 no 2904 0.142303640586657 4216 1270356 YLR208W SEC13
SGTC_1710 st031758 61.5 µM -1.07239010725716 0.132760464672942 no 2905 0.141772424735431 4195 5394341
SGTC_2774 tamoxifen 10.92 µM -1.07246895575982 0.132742969325319 no 2906 0.141754725220392 4150 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_3032 9089427 49.47 µM -1.07385810696007 0.13243499708083 no 2907 0.141443140994813 4176 17173707
SGTC_941 3237-0776 460 µM -1.07444845321648 0.132304267612689 no 2908 0.141310867980813 4207 760008
SGTC_842 0271-0008 11.1 µM -1.075186349871 0.132140988897721 no 2909 0.141145652754261 4214 1221709
SGTC_3346 9158254 43.5805 µM -1.07589933991965 0.131983353443645 no 2910 0.14098613858914 4163 17639500
SGTC_2768 sulfasalazine 50.2 µM -1.07686514183365 0.131770030543097 no 2911 0.140770258985023 4120 5384001 An antioxidant and salicylic acid derivative.
SGTC_14 0354-0009 295 µM -1.08015982292849 0.131044103603319 no 2912 0.140035508025688 4255 1713507
SGTC_2483 5729050 27.16 µM -1.08020792887441 0.131033524781928 no 2913 0.140024799195533 4202 2865180
SGTC_2370 9071495 200 µM -1.08294005321306 0.130433680381682 no 2914 0.13941751607869 4187 21791103
SGTC_2194 5927483 104.545 µM -1.08578921888179 0.129810165145021 no 2915 0.138786128642929 4217 760979
SGTC_140 0062-0056 502.533 µM -1.08705916876076 0.129532913658938 no 2916 0.13850533067715 4104 3758964
SGTC_105 0111-0055 734.78 µM -1.08761433403055 0.129411840674869 no 2917 0.138382700060968 4187 5179370
SGTC_3348 9149464 3.537 µM -1.08991442722289 0.128911061399425 no 2918 0.137875420380799 4134 1951442
SGTC_3026 9090633 49.47 µM -1.09127120787376 0.128616292401773 no 2919 0.137576781484583 4186 25236842
SGTC_298 1391-0729 10 µM -1.09182833160503 0.128495389389447 no 2920 0.137454281810022 4115 3237558
SGTC_1447 4239-0816 81.9 µM -1.09302876900417 0.128235147215559 no 2921 0.137190584292762 4190 1341554
SGTC_3249 9135183 49.47 µM -1.09401934660259 0.128020676236924 no 2922 0.136973246618199 4178 4902779
SGTC_579 4491-1009 110 µM -1.09464958482531 0.127884352484968 no 2923 0.136835091736377 4302 1271041
SGTC_3161 9100388 49.47 µM -1.09528354998756 0.127747324378221 no 2924 0.136696215995603 4260 25236368
SGTC_3062 9077494 49.47 µM -1.09567129638732 0.127663565425384 no 2925 0.136611324188106 4159 16459633
SGTC_159 3970-0959 50 µM -1.09595239736892 0.12760286733415 no 2926 0.136549803492293 4263 6615653
SGTC_2991 9074669 71.4286 µM -1.09693838738231 0.127390121289547 no 2927 0.136334163254804 4183 17333109
SGTC_318 1488-0629 67.2 µM -1.10175250334464 0.126354927765327 no 2928 0.135284642231615 4231 3662576
SGTC_2970 9090938 41.86 µM -1.10413102814173 0.125845635907102 no 2929 0.134768151682813 4275 17217104
SGTC_1905 st060207 84.5 µM -1.10550907092266 0.12555122405238 no 2930 0.134469533042131 4172 1948547
SGTC_3059 1327-0034 3 µM -1.10594257760603 0.125458707008916 no 2931 0.134375687160216 4069 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1334 1486-0610 236 µM -1.10920015942419 0.12476501069684 no 2932 0.133671921927418 4274 3742339
SGTC_2938 9059746 27.26 µM -1.11047832110347 0.124493561961734 no 2933 0.133396482414817 4209 6471769
SGTC_1400 3771-8998 51.5 µM -1.11106820699995 0.124368424695055 no 2934 0.13326949576384 4110 670767
SGTC_2171 5739187 198.077 µM -1.11476199988095 0.123586830511072 no 2935 0.132476212249597 4140 2262761
SGTC_1914 st062367 72.6 µM -1.11517196857182 0.123500295063157 no 2936 0.132388367892991 4203 978205
SGTC_2138 5575593 77.673 µM -1.11567683364475 0.123393787383128 no 2937 0.132280245172447 4202 762213
SGTC_3310 9130229 44.1445 µM -1.11627464483234 0.123267754772582 no 2938 0.132152295691049 4249 7761258
SGTC_3112 9123419 49.47 µM -1.11676020568122 0.123165453571711 no 2939 0.132048433960453 4266 17015854
SGTC_406 estrone 100 µM -1.11867616790181 0.122762366538395 no 2940 0.131639157949083 4204 5870 A steroid.
SGTC_6 0844-0013 19.835 µM -1.11956362855513 0.122575973240708 no 2941 0.131449881055592 4346 1584900
SGTC_607 4491-0986 66.8 µM -1.12110455655131 0.122252804109685 no 2942 0.131121679682808 4238 698981 YDR232W HEM1
SGTC_732 3970-1727 52.7 µM -1.12273807827978 0.121910869500528 no 2943 0.130774375394559 4287 1275699
SGTC_1953 st076800 12.1 µM -1.12306082010396 0.121843391580845 no 2944 0.130705832305896 4198 297591
SGTC_1248 0469-0687 58.6 µM -1.12321608617167 0.121810938353567 no 2945 0.130672866142435 4195 4017482
SGTC_3083 9117465 49.47 µM -1.12366740547446 0.121716639489522 no 2946 0.130577074459109 4214 16420915
SGTC_2393 9031399 185.94 µM -1.12453323915064 0.121535875427543 no 2947 0.130393438826271 4256 1526623 YDL150W RPC53
SGTC_1351 1496-0003 46.5 µM -1.13109972789159 0.120171100720038 no 2948 0.129006559413388 4246 3891978
SGTC_671 0560-0003 407 µM -1.13155700488572 0.120076464375856 no 2949 0.128910362347769 4137 3238678
SGTC_1930 st074634 34.3 µM -1.13229802156145 0.119923217866605 no 2950 0.128754580805611 4123 684253 YOR116C RPO31
SGTC_1690 st023502 41.2 µM -1.13274593686487 0.119830653290737 no 2951 0.128660480375991 4225 24207482
SGTC_1091 telmisartan 47.6 µM -1.13355163771376 0.119664276859975 no 2952 0.1284913346029 4254 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2864 9034755 47.6 µM -1.13363843909433 0.119646362186724 no 2953 0.128473121065368 4152 4930451
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.13409180260641 0.119552824609552 no 2954 0.128378020903492 4258 4174840
SGTC_2903 5923464 63.88 µM -1.13480152059228 0.119406499798017 no 2955 0.12822924449765 4230 2876576
SGTC_889 0919-1524 82.7 µM -1.13547870813406 0.119266999746256 no 2956 0.128087399033251 4249 3905452
SGTC_3016 9080866 49.47 µM -1.13567430646423 0.11922672807666 no 2957 0.128046448792644 4203 17066299
SGTC_447 ml7 120 µM -1.13658504741378 0.119039342340021 no 2958 0.127855896882067 4268 4216 Selective myosin light chain kinase inhibitor.
SGTC_752 1896-0090 130 µM -1.13955443692563 0.118429832444963 no 2959 0.127235988395192 4225 772567
SGTC_3262 9137218 49.47 µM -1.14104329556386 0.118125054508387 no 2960 0.126925953197139 4149 17650664
SGTC_1343 1487-0095 224 µM -1.14133881323803 0.118064626375093 no 2961 0.126864478134767 4242 4560101 YGL055W OLE1
SGTC_1 0258-0098 57.368 µM -1.14249553847121 0.11782830683728 no 2962 0.126624049746734 4180 6790032 YDR047W HEM12
SGTC_20 0481-0013 4.944 µM -1.14316897902408 0.117690876855601 no 2963 0.126484219604988 4271 182045
SGTC_935 2996-0153 430 µM -1.14483294467088 0.117351795572986 no 2964 0.126139182701386 4237 23738523
SGTC_682 0kpi-0099 17 µM -1.14531157158349 0.11725438970408 no 2965 0.126040057110848 4251 1714895 YML126C ERG13
SGTC_3040 9091894 49.47 µM -1.1467197502497 0.116968141921681 no 2966 0.125748732552213 4086 25236966
SGTC_822 1487-0950 154 µM -1.14802063722505 0.11670414426757 no 2967 0.12548002223601 4248 1958375
SGTC_1039 k821-0043 94 µM -1.14933740498467 0.116437354334888 no 2968 0.125208439972766 4235 15992768
SGTC_25 0118-0223 35.662 µM -1.15004240691669 0.116294692054589 no 2969 0.125063202727906 4245 5333628
SGTC_3248 9135562 49.47 µM -1.15050713700717 0.116200718382337 no 2970 0.124967528187206 4226 17650701
SGTC_2911 7942208 15.64 µM -1.1517533969932 0.115948976603606 no 2971 0.124711211593097 4277 1243384
SGTC_546 peri-Naphthalide 147 µM -1.15198670988213 0.115901890975349 no 2972 0.124663267309363 4170 223824 A penicillin ester.
SGTC_456 gingerol 170 µM -1.15431912388514 0.115431925133951 no 2973 0.124184679463623 4283 442793 A herb.
SGTC_1504 k297-0033 30 µM -1.15705649898918 0.11488209158202 no 2974 0.123624638930425 4126 4388117
SGTC_2074 5212007 75.395 µM -1.15731429572993 0.114830406263488 no 2975 0.123571987474364 4136 758611
SGTC_885 0865-0106 16.8 µM -1.16174461369449 0.113944761662557 no 2976 0.122669608928325 4197 2793380
SGTC_545 4218-0007 221 µM -1.162365377663 0.11382105738057 no 2977 0.122543540291832 4229 2840508
SGTC_934 2950-0684 338 µM -1.16247345004435 0.113799530773953 no 2978 0.122521601569459 4287 1121253
SGTC_2502 avocadyne acetate 18.59 µM -1.16412396291792 0.113471130660006 no 2979 0.122186889416451 4192 3952079
SGTC_1009 4106-0057 9.87 µM -1.16545687954125 0.113206415893278 no 2980 0.121917052462971 4251 2928005
SGTC_2489 cantharidin 73.42 µM -1.16569776010546 0.113158624504153 no 2981 0.121868333056062 4201 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_852 0418-0143 439 µM -1.16590918056468 0.113116689947445 no 2982 0.121825583387169 4257 5369229
SGTC_640 3381-0960 37.1 µM -1.16686841670301 0.112926567887169 no 2983 0.121631756128277 4324 1745025
SGTC_3355 9151058 44.0485 µM -1.16922909051396 0.112459650437287 no 2984 0.121155671810671 4270 17015728
SGTC_2192 5915882 198.485 µM -1.17303612971751 0.111709564958623 no 2985 0.120390658716671 4232 2876149
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.17975937499347 0.110393665247625 no 2986 0.119047965688192 4230 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2354 9060492 162 µM -1.18003988053126 0.11033900616905 no 2987 0.118992176874958 4294 6471895
SGTC_1336 1486-0901 104 µM -1.18347108306941 0.109671974954885 no 2988 0.118311250133872 4284 5006114
SGTC_1007 4101-0031 70 µM -1.18365439858849 0.109636419769571 no 2989 0.118274948603375 4237 1146276
SGTC_1053 3366-3204 134 µM -1.18541655344747 0.109295060958865 no 2990 0.11792639498859 4293 3632071 YPR165W RHO1
SGTC_310 1273-0058 1.06 µM -1.18634793565495 0.109114945426431 no 2991 0.117742461749656 4084 2734232
SGTC_250 brefeldin a 552.239 µM -1.18720664753585 0.108949072343398 no 2992 0.117573059720114 4153 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1273 0849-0096 14.1 µM -1.18781784532975 0.108831120791883 no 2993 0.11745259108448 4293 5286025
SGTC_2759 disulfiram 3.38 µM -1.18979277996338 0.108450617221927 no 2994 0.117063924029179 4181 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1451 4152-0210 104 µM -1.19001164418016 0.10840850842565 no 2995 0.117020907718869 4324 659563
SGTC_1237 0330-0133 46.1 µM -1.19071761708302 0.108272761607307 no 2996 0.116882229766708 4215 X1237 YHR072W ERG7
SGTC_1621 st003705 32.4 µM -1.19104613519433 0.10820963477803 no 2997 0.116817736964946 4275 24207032
SGTC_2717 st081029 62.2815 µM -1.19199114457983 0.108028192978025 no 2998 0.116632358775254 4251 5292846
SGTC_3197 9113331 49.47 µM -1.19242954227575 0.107944095043702 no 2999 0.116546431165165 4287 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_213 1246-0773 967 nM -1.19289695805842 0.10785448250368 no 3000 0.116454865364665 4295 6251622
SGTC_780 0109-0199 192 µM -1.19332004399869 0.107773415052677 no 3001 0.116372027699668 4349 610414
SGTC_803 4488-1585 147 µM -1.19643298959028 0.107178293190598 no 3002 0.115763816988231 4267 747204
SGTC_1303 1160-0052 261 µM -1.19851693267943 0.106781218801239 no 3003 0.115357917526359 4228 3562476
SGTC_1521 st012942 49.4 µM -1.1993868564091 0.106615778022586 no 3004 0.115188777962017 4244 24207259
SGTC_724 3910-0327 137 µM -1.19950644340858 0.106593049621088 no 3005 0.115165540412832 4328 2885483
SGTC_2685 mycophenolic acid 18.85 µM -1.20230975757942 0.106061260443104 no 3006 0.114621768920726 4272 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3233 9132340 49.47 µM -1.20393547030595 0.105753742001757 no 3007 0.114307260420497 4287 17682950
SGTC_1108 betulinic acid 729.144 nM -1.20418947646318 0.105705752693509 no 3008 0.114258176241841 4282 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.204307553372 0.105683449819205 no 3009 0.114235364157602 4389 688801
SGTC_1493 4348-0038 111 µM -1.20697336779409 0.105180824505708 no 3010 0.113721200286407 4257 800424
SGTC_397 arbidol 50 µM -1.21092361136872 0.10443921114902 no 3011 0.112962341231215 4325 131410 A RNA synthesis inhibitor.
SGTC_2619 obliquin 87.91 µM -1.21167811779191 0.104297993145949 no 3012 0.11281780931206 4254 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2720 fluspirilene 36.88 µM -1.21514034577792 0.103651755966379 no 3013 0.112156283959794 4278 3396 An atypical antipsychotic.
SGTC_3223 9129970 49.47 µM -1.21747804618595 0.103217062059705 no 3014 0.111711192165865 4299 17248386
SGTC_1153 4055-0057 267 µM -1.2186987655145 0.102990596881284 no 3015 0.111479273346909 4352 882706
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.21959480951424 0.102824594619762 no 3016 0.111309257515792 4286 16623 A steroid.
SGTC_2380 9035439 200 µM -1.2201618614428 0.102719642351985 no 3017 0.111201760747905 4391 6462575
SGTC_2877 9040724 71.43 µM -1.22089472474865 0.102584116402436 no 3018 0.111062941040908 4285 6463895
SGTC_1697 st025554 27.742 µM -1.22153711222343 0.102465428788285 no 3019 0.110941361466675 4298 1269519
SGTC_2754 granisetron 64.02 µM -1.22160921942494 0.102452112485234 no 3020 0.110927720263078 4298 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_914 3820-6779 408 µM -1.22210095750224 0.102361334948576 no 3021 0.110834725539606 4250 2893481
SGTC_1937 st074714 47.2 µM -1.22223068087034 0.102337397059527 no 3022 0.110810202303812 4247 17250970
SGTC_1654 st012436 41.8 µM -1.22272718302802 0.102245814989314 no 3023 0.110716378187022 4304 4323132
SGTC_1193 1488-0126 41.5 µM -1.2231835434084 0.102161689843312 no 3024 0.110630189893183 4275 1384710
SGTC_1364 1653-0028 37.6 µM -1.22422032932533 0.101970756635274 no 3025 0.110434561087156 4298 5718652
SGTC_1703 st026983 48.3 µM -1.2244806320289 0.101922860421506 no 3026 0.110385484130173 4330 1104023
SGTC_1130 3454-2858 15.9 µM -1.22533844132913 0.101765137694351 no 3027 0.110223865146956 4299 715628 YIL048W NEO1
SGTC_2474 5321570 43.32 µM -1.22555917382028 0.101724581056012 no 3028 0.110182304630252 4289 2841384
SGTC_2221 6807166 181.081 µM -1.22805484711255 0.101266852944832 no 3029 0.109713189740562 4270 674925
SGTC_864 0469-0573 172 µM -1.23200801946614 0.100544881100134 no 3030 0.108973044231726 4280 689425
SGTC_2533 agelasine 13.65 µM -1.23211503153267 0.100525389715145 no 3031 0.108953058566754 4376 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1831 st055328 12 µM -1.23330617400099 0.100308618811105 no 3032 0.108730777651632 4297 1103068
SGTC_2804 7954240 19.48 µM -1.23564942872256 0.0998831760361587 no 3033 0.108294451501601 4334 828705
SGTC_3265 9137266 49.47 µM -1.23655106115237 0.0997198267054216 no 3034 0.108126899039606 4278 17224265
SGTC_816 0325-0417 81.3 µM -1.23666654468856 0.099698918586604 no 3035 0.108105451953778 4349 68101
SGTC_2766 oltipraz 83.91 µM -1.23693363570875 0.0996505744334773 no 3036 0.108055860737011 4287 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_686 1319-0111 510 µM -1.23702296288722 0.0996344098101463 no 3037 0.108039278872444 4359 4562600
SGTC_1884 5633444 25 µM -1.2382734786305 0.0994083179279957 no 3038 0.107807337117912 4296 5724239
SGTC_2798 7813637 45.45 µM -1.23836386702919 0.0993919903496047 no 3039 0.10779058606988 4312 956368
SGTC_1431 4049-0260 9.09 µM -1.23951526234628 0.099184176131104 no 3040 0.107577370082123 4327 3854841
SGTC_1779 st039427 55 µM -1.23986253792672 0.0991215591150178 no 3041 0.107513121103313 4304 1124498
SGTC_2446 5162541 200 µM -1.23996627397121 0.0991028601509019 no 3042 0.10749393440507 4276 1549321
SGTC_1118 chelidonine 707.474 nM -1.24062008964953 0.0989850658285402 no 3043 0.107373063465375 4301 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_476 mead acid 10 µM -1.24193055686066 0.0987492747060595 no 3044 0.107131092366291 4375 5312531 An omega 9 fatty acid.
SGTC_3337 9144342 33.5465 µM -1.24437996748741 0.0983096572325159 no 3045 0.106679876071309 4315 17682949
SGTC_2973 9094665 17.96 µM -1.24638218619423 0.0979513673481129 no 3046 0.106312058993423 4323 25237061 YIL048W NEO1
SGTC_631 k072-0230 41.5 µM -1.24640656252229 0.0979470111953391 no 3047 0.106307586596457 4319 5773147
SGTC_332 4112-0506 40.9 µM -1.25007264591204 0.0972934819123657 no 3048 0.105636505559907 4299 2790355
SGTC_1594 piperine 70.1 µM -1.25416931069666 0.0965669870815801 no 3049 0.104890236021728 4310 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_801 0866-0028 10.1 µM -1.25940979730137 0.0956434689129429 no 3050 0.103941176255343 4346 6849771
SGTC_2868 9035608 32.47 µM -1.25974341055856 0.0955848978478422 no 3051 0.103880969939063 4322 6462614
SGTC_843 0310-0051 143 µM -1.26108595729858 0.0953494594406946 no 3052 0.103638939726249 4355 2065037
SGTC_387 norethindrone acetate 66.7 µM -1.26121454586812 0.0953269316711532 no 3053 0.103615779662328 4347 541197
SGTC_3048 9093155 49.47 µM -1.26181302714501 0.0952221337218876 no 3054 0.103508036722848 4302 25236002
SGTC_1848 st056003 16.4 µM -1.2652302825157 0.0946253748959864 no 3055 0.102894394993234 4348 146492
SGTC_374 0880-0231 82.3 µM -1.26588943680975 0.0945105839509179 no 3056 0.102776334371128 4214 6833587
SGTC_1972 st070201 17.4 µM -1.26845405885149 0.0940649348156775 no 3057 0.102317923487325 4353 2829099
SGTC_245 methotrexate 289.6 µM -1.27078186851088 0.0936617801437141 no 3058 0.101903130420304 4307 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1362 1611-0397 101 µM -1.2779174657516 0.0924339129149139 no 3059 0.100639264509722 4312 27816
SGTC_1500 4488-1866 171 µM -1.28170484416553 0.0917870532333276 no 3060 0.0999731024996956 4410 2900003
SGTC_3245 9134821 49.47 µM -1.28215128960745 0.0917110247298347 no 3061 0.0998947898698974 4363 17014901
SGTC_1855 st056195 39.6 µM -1.28347436431583 0.0914859825624143 no 3062 0.0996629676531409 4285 4028379
SGTC_559 1550-0661 158 µM -1.29224278556065 0.0900048944043372 no 3063 0.0981365394559603 4417 5830875
SGTC_3320 9137005 35.139 µM -1.29329626140353 0.0898281559200224 no 3064 0.0979543066032082 4405 4908713
SGTC_391 gliotoxin 8.33 µM -1.2934368597702 0.0898045876784404 no 3065 0.09793000432013 4436 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_846 0335-0850 148 µM -1.29396819996521 0.0897155616215211 no 3066 0.0978382026177877 4340 6819598
SGTC_320 4092-0846 5.34 µM -1.29426572195923 0.0896657404715046 no 3067 0.0977868261487559 4316 1359356
SGTC_2655 perillic acid 100 µM -1.29695014303257 0.0892171540730066 no 3068 0.0973241709425125 4397 5702197 An apoptosis inducer.
SGTC_3120 9124077 49.47 µM -1.29910667531103 0.0888579930418037 no 3069 0.096953661285961 4499 18774327 YGL155W CDC43
SGTC_1669 st015249 58.4 µM -1.29953810500056 0.0887862697169147 no 3070 0.0968796626479125 4469 722793
SGTC_143 4032-1194 15.74 µM -1.30236819774975 0.0883168476016868 no 3071 0.0963952743223713 4400 1806963
SGTC_1344 1488-0097 29.1 µM -1.30678562909606 0.0875878370631034 no 3072 0.095642763605087 4410 747966
SGTC_2782 7736369 71.43 µM -1.30717899064496 0.0875231388150942 no 3073 0.0955759645287657 4368 2950836 YOL077C BRX1
SGTC_736 0958-0254 92.6 µM -1.30921716547275 0.0871884805105088 no 3074 0.0952303996256414 4434 6812352
SGTC_455 paf C-16 10 µM -1.31226702880957 0.0866894939009569 no 3075 0.0947150263818046 4333 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.31675188838078 0.085959609485474 no 3076 0.0939609022528412 4383 390807
SGTC_1052 3253-3998 198 µM -1.32036694216977 0.0853746358329413 no 3077 0.0933562675872885 4313 5450317
SGTC_3351 9150312 21.596 µM -1.32091005096981 0.0852870103875037 no 3078 0.0932656790101546 4287 4904905
SGTC_835 0312-0010 67.2 µM -1.32246502521382 0.0850365026932405 no 3079 0.0930066741493781 4389 1626196
SGTC_2382 9035899 200 µM -1.32275550490734 0.0849897673590839 no 3080 0.0929583492866323 4370 6462679
SGTC_2212 7123476 200 µM -1.32311356752127 0.0849321850920886 no 3081 0.0928988067208798 4388 1085715
SGTC_2105 5350118 200 µM -1.32488907764516 0.0846470863117707 no 3082 0.0926039720183285 4354 2133313
SGTC_995 3931-2021 34.6 µM -1.328059689786 0.084139758256146 no 3083 0.092079194398169 4387 730143
SGTC_2238 6671620 73.2395 µM -1.33360934723217 0.0832572597527646 no 3084 0.0911659589951873 4299 729941
SGTC_967 1306-0166 352 µM -1.33515333797032 0.083012978304422 no 3085 0.0909130826809772 4402 4437607
SGTC_632 0781-2353 4.65 µM -1.33701688819455 0.0827188564379375 no 3086 0.0906085621421648 4440 6811515 YHR007C ERG11
SGTC_531 3788-1495 174 µM -1.33729265849114 0.0826753986407376 no 3087 0.0905635632313299 4382 2896655
SGTC_1443 4112-3303 14 µM -1.33807306187583 0.082552510375156 no 3088 0.0904363105514109 4430 704433
SGTC_3173 9105693 49.47 µM -1.340794475721 0.0821250514781053 no 3089 0.0899935951532128 4372 17096658
SGTC_2983 9022671 12.99 µM -1.34326831404261 0.0817379285239561 no 3090 0.0895925541243481 4386 6405161
SGTC_1479 0549-0158 134 µM -1.34422610759791 0.0815884164608684 no 3091 0.0894376408448028 4450 5440202
SGTC_350 k064-0020 19.8 µM -1.34602343586731 0.0813084092867361 no 3092 0.0891474793065326 4420 2790705
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.35454989629667 0.0799899349684537 no 3093 0.0877805029794183 4391 521171
SGTC_1887 st057648 70.8 µM -1.3548284601134 0.0799471340596542 no 3094 0.0877361084050833 4404 688672
SGTC_3180 9109287 49.47 µM -1.35929908461201 0.0792625964647028 no 3095 0.0870259170036051 4443 18891271
SGTC_620 0109-0052 432 µM -1.36035880229358 0.0791009860171138 no 3096 0.0868582043797706 4462 493037
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.3619580582696 0.0788575668098761 no 3097 0.0866055609296717 4275 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3349 9149703 23.001 µM -1.36971264892415 0.0776852989800652 no 3098 0.0853883093189519 4429 4910494
SGTC_1954 st077032 68.9 µM -1.37440103213474 0.0769829972600966 no 3099 0.0846586079556644 4355 698907
SGTC_1801 st050089 28.441 µM -1.3747725595675 0.0769275509137818 no 3100 0.0846009839211281 4463 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1087 pterostilbene 9.05 µM -1.37595305020719 0.0767515772437343 no 3101 0.0844180846585762 4418 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1995 st072814 61.1 µM -1.37612174968451 0.0767264545247624 no 3102 0.0843919714595554 4397 5769371
SGTC_1033 k072-0102 21.3 µM -1.37670297445051 0.0766399464411946 no 3103 0.084302049378725 4385 5965931
SGTC_2012 4023501 200 µM -1.37717123251191 0.0765703060181167 no 3104 0.0842296568471739 4418 3477460
SGTC_1899 st063254 59.6 µM -1.37839937791635 0.0763878820684117 no 3105 0.084040007683394 4378 3093813
SGTC_164 4100-3994 89.624 µM -1.3895137576614 0.0747520035076172 no 3106 0.0823382901926863 4413 4615967
SGTC_3155 9099265 49.47 µM -1.39376923151006 0.0741327838881488 no 3107 0.0816936511435453 4403 25236499
SGTC_373 0844-0104 25.9 µM -1.39475211250578 0.073990322136254 no 3108 0.0815453020636423 4447 5375804
SGTC_3234 9132280 49.47 µM -1.39555555317595 0.073874024464686 no 3109 0.0814241874004198 4460 17612295
SGTC_3225 9130819 49.47 µM -1.39643773682331 0.0737464897401295 no 3110 0.0812913589522251 4388 4547121
SGTC_251 melphalan 456.522 µM -1.39898638773941 0.0733789840987211 no 3111 0.0809085325356528 4473 460612 A DNA alkylator.
SGTC_3130 9127414 49.47 µM -1.39907254262557 0.0733665854171505 no 3112 0.0808956152495394 4448 1494646
SGTC_99 0109-0120 622.8 µM -1.39929702127321 0.0733342878780488 no 3113 0.0808619662597767 4444 759414
SGTC_2451 5856223 45.7 µM -1.40340640914238 0.072744957502261 no 3114 0.080247841444598 4425 2179896
SGTC_2057 5236571 38.335 µM -1.40444046826134 0.0725972349300933 no 3115 0.0800938636767095 4378 54684039 YBR257W POP4
SGTC_118 0083-0097 135.343 µM -1.40482141725041 0.0725428716547357 no 3116 0.0800371943601998 4420 5207356
SGTC_41 0478-0632 82.643 µM -1.40489686331195 0.0725321088347324 no 3117 0.0800259747310239 4424 3750424
SGTC_2905 7799065 20.05 µM -1.40495431432835 0.072523913933077 no 3118 0.0800174319533637 4314 1296806
SGTC_3051 9093778 49.47 µM -1.40646422678759 0.0723087918625218 no 3119 0.0797931600349895 4530 17217378
SGTC_1296 1068-0102 11.9 µM -1.41070183810046 0.0717076575774632 no 3120 0.0791662743876589 4448 767053
SGTC_962 1254-0300 21.5 µM -1.4110273341461 0.0716616427412948 no 3121 0.0791182772035876 4413 7340576
SGTC_1476 4112-3294 3.34 µM -1.41235268873176 0.0714745134366665 no 3122 0.0789230698179147 4447 704369
SGTC_2337 9009472 200 µM -1.41738422853618 0.0707675136483526 no 3123 0.0781853106162393 4419 5742383
SGTC_1277 0873-0036 22 µM -1.41802469660677 0.0706779060487765 no 3124 0.0780917772919985 4518 5965735
SGTC_1970 st070122 35.8 µM -1.42150379334321 0.0701926697502096 no 3125 0.0775851757892046 4453 102928
SGTC_2830 7992007 71.43 µM -1.42237259856507 0.070071896562033 no 3126 0.0774590567341816 4338 1952075
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.42449085543587 0.0697781063385972 no 3127 0.077152215176187 4493 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2004 4023728 41.89 µM -1.42585065623151 0.0695900099229993 no 3128 0.0769557276009821 4405 360084 YDR527W RBA50
SGTC_3190 9110366 49.47 µM -1.43497260563958 0.0683382811676336 no 3129 0.0756474520342459 4466 17123768
SGTC_2828 7998861 71.43 µM -1.43822499907408 0.0678962083306388 no 3130 0.0751851121402497 4446 2988188
SGTC_1689 st020265 53.493 µM -1.43980569161639 0.0676821559683448 no 3131 0.0749611902371687 4457 5758320 YPR016C TIF6
SGTC_1938 st074717 56.4 µM -1.44026741174639 0.0676197297776713 no 3132 0.0748958787607772 4327 17250979
SGTC_2981 9013952 38.96 µM -1.44036244455273 0.0676068865291118 no 3133 0.0748824415190832 4407 2996344
SGTC_1923 st058458 19.1 µM -1.44577660342972 0.0668782955586323 no 3134 0.0741199352130427 4460 3534982
SGTC_2210 7115885 190.385 µM -1.44704200694699 0.0667088873940516 no 3135 0.0739425794037322 4542 2927039
SGTC_1187 1391-0724 117 µM -1.44925243157781 0.0664137597654106 no 3136 0.0736335500023364 4510 6997986
SGTC_178 4092-0806 87.505 µM -1.44973746411448 0.066349135490358 no 3137 0.073565872104784 4352 2169044
SGTC_2009 4012297 12.05 µM -1.45956445001234 0.0650502786500312 no 3138 0.0722049077699834 4448 45595307
SGTC_731 3966-0296 387 µM -1.4641459858445 0.0644515109604702 no 3139 0.0715770324086409 4471 660956
SGTC_3343 9148379 18.9835 µM -1.46927028096046 0.0637868919750544 no 3140 0.070879747139621 4482 1955036
SGTC_2276 7947513 42.08 µM -1.47306612714909 0.0632980186658946 no 3141 0.0703666029571779 4408 2105100
SGTC_1473 k844-0725 134 µM -1.47524499204322 0.063018719701558 no 3142 0.0700733446775041 4517 54682906
SGTC_2027 5150920 200 µM -1.47773078554087 0.0627012502542744 no 3143 0.0697399254197874 4435 786715
SGTC_441 propafenone 146 µM -1.4782671765588 0.0626329096440774 no 3144 0.069668139784302 4464 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_595 3909-8003 73.7 µM -1.47991919014041 0.0624227943128137 no 3145 0.0694474068663316 4545 699517
SGTC_1964 st076914 61 µM -1.48423597215567 0.0618763482902664 no 3146 0.068873164862252 4525 24208661
SGTC_1991 st073000 8.92 µM -1.48536067690437 0.0617345908113402 no 3147 0.0687241532358243 4512 4301969 YIL048W NEO1
SGTC_1534 6-azauridine 81.6 µM -1.49196036370888 0.060907870976864 no 3148 0.0678547682276895 4518 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1717 st033143 58.0435 µM -1.49318692256764 0.0607551824403749 no 3149 0.0676941321602833 4517 674616
SGTC_650 1328-0195 38 µM -1.49619736868677 0.06038169516534 no 3150 0.0673011150349581 4496 2780821
SGTC_317 4495-0002 170 µM -1.49747065265081 0.060224268476581 no 3151 0.0671354181436443 4504 15991618
SGTC_2423 st077119 87.2 µM -1.5001390332846 0.0598953967071024 no 3152 0.066789195889752 4412 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1263 0774-1208 64.8 µM -1.50182340486096 0.0596885270772184 no 3153 0.066571361057282 4495 906585
SGTC_2471 5466956 24.79 µM -1.50278067234363 0.0595712080035024 no 3154 0.0664478057780781 4493 724419
SGTC_793 0488-0545 106 µM -1.50564530768126 0.05922120854274 no 3155 0.0660791254761351 4514 292548
SGTC_89 0302-0250 142.109 µM -1.50658587261496 0.0591066431940571 no 3156 0.0659584204080722 4570 4203518 YLR208W SEC13
SGTC_2756 carbadox 75.1 µM -1.51213375466452 0.0584344174349518 no 3157 0.0652499196680037 4433 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1266 0828-0227 32.9 µM -1.51951568862321 0.0575492897609327 no 3158 0.0643163710367551 4475 3913820
SGTC_1289 0976-0073 69.1 µM -1.52045917041577 0.057436926083204 no 3159 0.0641978064688156 4565 3391136
SGTC_3294 9122953 26.2835 µM -1.52079099576176 0.0573974484951919 no 3160 0.0641561473653486 4487 16459826
SGTC_136 0097-0015 404.482 µM -1.52079849410326 0.057396556656839 no 3161 0.064155206226879 4496 4861337
SGTC_723 4182-0001 115 µM -1.53351418669505 0.0558997973962491 no 3162 0.0625746069478795 4517 744821 YLR208W SEC13
SGTC_1247 0448-0043 5.84 µM -1.53400382830981 0.0558427834732442 no 3163 0.0625143554846036 4493 3089013 YGL099W LSG1
SGTC_2887 9044784 58.44 µM -1.53446914049465 0.0557886449973883 no 3164 0.0624571397334928 4439 6465546
SGTC_1208 2323-2347 50.3 µM -1.5351019165511 0.0557150887783502 no 3165 0.0623793978029534 4523 5412760
SGTC_44 0929-0055 61.211 µM -1.5365487047518 0.0555471963352304 no 3166 0.0622019310582677 4384 1379590
SGTC_2700 st077718 96.8 µM -1.54056767479309 0.0550829103554168 no 3167 0.0617110201433134 4487 904970
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.54239108541574 0.0548732769507782 no 3168 0.0614892932725215 4589 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1677 st019204 53.9 µM -1.54409791717453 0.0546776182124758 no 3169 0.0612823066848174 4514 3945625
SGTC_907 3448-6986 75.5 µM -1.5543096812261 0.0535185137111373 no 3170 0.0600552826690857 4528 590582
SGTC_741 4582-0002 126 µM -1.5590035350652 0.0529923016942066 no 3171 0.0594977717362794 4545 2912688
SGTC_2107 5363541 170.161 µM -1.56587909008097 0.0522289233183742 no 3172 0.0586884629550734 4466 244052
SGTC_1738 st035555 74 µM -1.57444128606552 0.0512905195735548 no 3173 0.0576927326813259 4533 5331140
SGTC_1921 5740136 50 µM -1.59367464916407 0.0492314736963453 no 3174 0.0555044625469545 4476 1774243
SGTC_1862 st057513 3.81 µM -1.60266555005629 0.0482918544678327 no 3175 0.0545042566040417 4533 5393163
SGTC_1181 1222-0449 220 µM -1.60850006206926 0.0476898161628163 no 3176 0.0538628513097439 4571 658318
SGTC_1406 3909-7906 11.9 µM -1.61338167255667 0.0471907351277569 no 3177 0.0533308062024165 4583 X1406
SGTC_2526 patulin 37.61 µM -1.61667808703154 0.0468560941542018 no 3178 0.052973893195969 4555 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1398 3558-0053 112 µM -1.61808412381963 0.0467139382941288 no 3179 0.0528222347362754 4533 4532369
SGTC_1061 3448-9325 110 µM -1.62015923430409 0.0465047688497625 no 3180 0.0525990379284156 4522 723482
SGTC_1750 st081859 2.357 µM -1.62610559895232 0.0459095412278269 no 3181 0.0519635965876161 4460 5291695
SGTC_2553 4-methylesculetin 85.09 µM -1.62865677600146 0.0456560535993734 no 3182 0.0516928489207119 4550 5319502
SGTC_2190 6049624 200 µM -1.63277896508098 0.0452488475139286 no 3183 0.0512577463116673 4481 2265554
SGTC_756 0508-1999 28.3 µM -1.63744009260243 0.044791928264069 no 3184 0.0507692733836258 4586 6753853
SGTC_3272 9137413 49.47 µM -1.63875707146591 0.044663503291854 no 3185 0.050631931439475 4502 17614870
SGTC_108 0509-0257 621.132 µM -1.64448320788417 0.0441085640330519 no 3186 0.0500382150475876 4538 536624
SGTC_1764 st044502 93.5 µM -1.6486059381394 0.043712468848289 no 3187 0.0496141957067708 4588 8407
SGTC_3335 9143315 29.6265 µM -1.64878318750881 0.0436955040050582 no 3188 0.0495960302430051 4581 4899691
SGTC_500 h-89 112 µM -1.64965460470292 0.0436121764079014 no 3189 0.0495067999238522 4549 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_357 1325-0123 420 µM -1.66235768744215 0.0424119672765867 no 3190 0.0482205387398694 4564 1098503
SGTC_2424 5537928 59.2 µM -1.66308356505376 0.0423442001458963 no 3191 0.0481478546156636 4582 5382802
SGTC_1200 1643-0193 18.4 µM -1.67266547507532 0.0414578273855213 no 3192 0.0471965847403823 4595 5403974
SGTC_972 1319-0219 195 µM -1.6728349365533 0.041442287737757 no 3193 0.0471798975651226 4568 23903702
SGTC_1044 1222-0021 1.78 µM -1.67869656389088 0.040907674426849 no 3194 0.0466055979846989 4504 4306703
SGTC_1588 farnesol 29.9 µM -1.68213791227804 0.0405964194987177 no 3195 0.0462710501187598 4595 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1368 1852-0141 284 µM -1.70068917392296 0.0389514961190356 no 3196 0.0445006845464115 4556 2838987
SGTC_969 1313-0238 134 µM -1.70140316070719 0.038889288461438 no 3197 0.0444336541008172 4611 5212874
SGTC_1494 4358-1428 177 µM -1.70189113001564 0.0388468196326411 no 3198 0.0443878894263673 4606 1564571
SGTC_3244 9134489 49.47 µM -1.70240535990417 0.0388021061840015 no 3199 0.0443397029897632 4589 16584271
SGTC_430 0958-0115 16.4 µM -1.70410478496971 0.0386546354519826 no 3200 0.0441807564288612 4518 6833180
SGTC_3175 9106517 49.47 µM -1.71581807459338 0.0376505713871927 no 3201 0.0430976724776951 4610 41468073
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.71589251113738 0.0376442594256161 no 3202 0.043090858822072 4558 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_282 k297-0036 65.7 µM -1.71618566575681 0.0376194093276211 no 3203 0.0430640329558819 4592 5061378
SGTC_2643 anethole 100 µM -1.72542447304402 0.0368430922662601 no 3204 0.0422255020215819 4603 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2847 9005661 71.43 µM -1.72717630112866 0.0366973776555235 no 3205 0.0420680028264078 4638 2991449
SGTC_462 ag-879 158 µM -1.72727628082863 0.0366890757227944 no 3206 0.0420590284513317 4601 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2092 5303694 80.6725 µM -1.72824833742557 0.0366084399005886 no 3207 0.0419718554838768 4610 1963699
SGTC_1888 azatryptophan 97.5 µM -1.72893488239931 0.0365515757672187 no 3208 0.0419103750630483 4609 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2094 5332512 191.667 µM -1.72955673996942 0.0365001318595873 no 3209 0.0418547503800993 4621 755774
SGTC_225 nsc-122657 1.016 µM -1.73282186456753 0.036230991878877 no 3210 0.041563667698368 4608 275685
SGTC_214 4373-3496 70 µM -1.7345497835959 0.0360892204862634 no 3211 0.0414102903003845 4657 3779166
SGTC_2085 5307070 144.047 µM -1.75630259686393 0.0343430106177275 no 3212 0.0395183770544927 4552 2840351
SGTC_2133 5320837 200 µM -1.75729980556141 0.0342646539095029 no 3213 0.0394333604659763 4614 2841355
SGTC_2726 cimetidine 79.27 µM -1.76122675738665 0.0339575170378481 no 3214 0.039100015478185 4635 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2860 9025725 38.96 µM -1.77390217690413 0.0329815551301933 no 3215 0.0380396663059201 4647 40546248
SGTC_272 doxorubicin 8.13 µM -1.77638165934137 0.0327933731412928 no 3216 0.037835015994265 4638 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.77686974000668 0.032756434401553 no 3217 0.0377948370638257 4642 688664
SGTC_1309 pyrazolanthrone 13.4 µM -1.77706267674586 0.0327418420986242 no 3218 0.0377789640666261 4614 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2884 9058502 51.95 µM -1.78236247959306 0.0323430954501008 no 3219 0.0373450699761781 4600 6471554
SGTC_2848 9016370 25.97 µM -1.7916206622397 0.0316561459281212 no 3220 0.0365968755197179 4596 7894410
SGTC_2467 5474540 200 µM -1.79370210328007 0.0315033763612749 no 3221 0.0364303647166748 4614 5413519
SGTC_119 0121-0043 24.815 µM -1.79406401472102 0.0314768757843109 no 3222 0.0364014759504425 4624 1092378
SGTC_2242 6630449 61.2675 µM -1.79460406159784 0.0314373657000809 no 3223 0.0363584027881629 4622 691249 YDR170C SEC7
SGTC_315 k915-0449 187 µM -1.7949867609224 0.0314093920664923 no 3224 0.0363279046443334 4651 20970215 YNL149C PGA2
SGTC_3321 9137793 26.8275 µM -1.79649379545648 0.0312994345042604 no 3225 0.0362080093016303 4610 4904192
SGTC_3123 9126162 49.47 µM -1.79708289408519 0.0312565388074763 no 3226 0.036161230462664 4612 25239884
SGTC_3228 9131799 49.47 µM -1.80257389915608 0.0308590408624528 no 3227 0.0357275796018173 4662 17015818
SGTC_1610 st001799 48.1 µM -1.8026386043716 0.0308543818651926 no 3228 0.0357224950411562 4597 621897
SGTC_1583 clindamycin 39.6 µM -1.80618514187928 0.0305999081570269 no 3229 0.0354447124944023 4629 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_905 2-aminofluorene 215 µM -1.81371925598338 0.0300650810527074 no 3230 0.0348604794792713 4643 1539 An established DNA mutagen. YPR165W RHO1
SGTC_248 streptozotocin 5.23457 mM -1.81590961867647 0.0299110550890578 no 3231 0.0346921187918908 4665 5300 DNA alkylating agent.
SGTC_1696 st025591 34.7925 µM -1.81632842447598 0.0298816793897005 no 3232 0.0346600037453415 4628 2787147
SGTC_2495 cafestol 54.53 µM -1.82530020142032 0.0292581100777159 no 3233 0.0339778699052407 4629 16667697 An anti-infammatory.
SGTC_289 k017-0060 526 µM -1.827590978639 0.0291006368925167 no 3234 0.0338054803681521 4634 5512909
SGTC_997 3996-0078 137 µM -1.83283583903292 0.0287427439256085 no 3235 0.0334134938281303 4671 735687
SGTC_522 1273-0010 11.6 µM -1.83562265426752 0.0285540740756353 no 3236 0.0332067421403793 4644 5705015
SGTC_228 caffeine 993.056 µM -1.84167895344995 0.0281476076913053 no 3237 0.0327610622711268 4635 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2725 haloperidol 53.21 µM -1.84179847243868 0.0281396349408767 no 3238 0.0327523167999626 4614 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1355 1499-0035 1.68 µM -1.84303135960863 0.0280575024405531 no 3239 0.0326622159815934 4645 1548538
SGTC_307 1501-1223 22.3 µM -1.84467389356333 0.027948390306559 no 3240 0.0325424953564124 4652 2830329
SGTC_2323 6148992 148.28 µM -1.84595294861818 0.0278636687319743 no 3241 0.0324495187734262 4602 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_18 0111-0177 500 nM -1.84982242638105 0.0276086654227713 no 3242 0.0321695737182611 4709 721752
SGTC_1495 4469-0029 237 µM -1.85565108672404 0.0272282236863968 no 3243 0.0317516534653082 4657 793680
SGTC_2097 5376186 200 µM -1.86053498615157 0.0269128240697561 no 3244 0.0314049366748138 4634 742755
SGTC_2956 9076196 2.52 µM -1.86812665340956 0.0264286170040996 no 3245 0.0308722096094498 4629 16423868
SGTC_2369 9071472 200 µM -1.87319423549681 0.0261094685218041 no 3246 0.0305207840290081 4664 17296037
SGTC_2513 baicalein 25.65 µM -1.8733960245809 0.0260968271753722 no 3247 0.0305068592883328 4619 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_296 1222-0039 74.9 µM -1.87797208731133 0.0258115250002703 no 3248 0.030192491825141 4666 5984176
SGTC_1464 k208-0027 110 µM -1.87938517484737 0.0257239529564881 no 3249 0.0300959595597289 4644 X1464
SGTC_3176 9106582 49.47 µM -1.88530193811945 0.0253599746224158 no 3250 0.0296945423226016 4682 17018027
SGTC_130 0136-0219 337.655 µM -1.88684711091055 0.025265634690762 no 3251 0.0295904462563054 4584 234244
SGTC_2721 ifenprodil 61.44 µM -1.89427852755976 0.0248160107600497 no 3252 0.0290940247935619 4623 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1519 esterone 74 µM -1.89713375626358 0.0246450543084367 no 3253 0.0289051435106647 4646 698 A steroid.
SGTC_2714 st079313 56.9 µM -1.90340250819032 0.0242731779331983 no 3254 0.028494022001346 4655 2939799
SGTC_964 1287-0107 19.4 µM -1.90724223787159 0.0240477322263691 no 3255 0.0282446131164717 4642 51516812 YPR165W RHO1
SGTC_3290 9121031 71.43 µM -1.91233298230363 0.023751549287082 no 3256 0.0279167489748343 4666 17014854
SGTC_53 0973-0023 39.979 µM -1.93982766019116 0.0222044074506379 no 3257 0.0262003189488407 4593 674768
SGTC_2134 5324836 1.464 µM -1.94387812051839 0.0219838353400493 no 3258 0.025955075140531 4655 699272
SGTC_3074 9116018 49.47 µM -1.94390182220397 0.0219825501035936 no 3259 0.0259536457423212 4682 17027303
SGTC_43 0570-0105 72.5 µM -1.95912446516837 0.0211700946523581 no 3260 0.0250491061517478 4640 1114046 YDL195W SEC31
SGTC_1195 1502-0147 41.1 µM -1.96171376901179 0.0210344588718471 no 3261 0.0248979089380001 4682 817940
SGTC_364 0083-0097 67.7 µM -1.98417485965564 0.0198884394569914 no 3262 0.0236181750695097 4670 5207356
SGTC_1069 diphenylcyclopropenone 8.49 µM -1.99357648700036 0.0194247192166319 no 3263 0.0230991785353678 4695 65057 A dermal irritant. YDR527W RBA50
SGTC_2428 5615643 7.78 µM -2.01242276136375 0.0185227737531791 no 3264 0.0220876955649127 4686 2253075
SGTC_486 niguldipine 82 µM -2.01881252842252 0.0182251796000111 no 3265 0.0217533541990268 4744 1236 A calcium channel blocker.
SGTC_1442 4112-3290 3 µM -2.02084810659422 0.0181312353280828 no 3266 0.0216477455877504 4711 704353
SGTC_286 k060-0067 22.9 µM -2.02608037885482 0.017891652011024 no 3267 0.0213782742166218 4721 5985051
SGTC_1808 st050063 61.5 µM -2.02772343720702 0.0178169764069276 no 3268 0.0212942411159283 4665 4011993
SGTC_1204 4049-0315 18.3 µM -2.03175084376018 0.0176350579643344 no 3269 0.0210894429253339 4667 588402
SGTC_3246 9135460 32.98 µM -2.03874335810279 0.0173229701574787 no 3270 0.0207378240094756 4704 41446951
SGTC_1440 4100-1550 40 µM -2.04200231502203 0.0171791366218231 no 3271 0.0205756508467246 4714 742806
SGTC_3289 9119912 71.43 µM -2.05432438675596 0.0166444912022847 no 3272 0.019972152979571 4681 17014829
SGTC_1866 st057638 64 µM -2.06367891208765 0.0162481719099576 no 3273 0.0195240850362862 4716 688802
SGTC_1158 4092-0494 91.8 µM -2.080129048729 0.0155708291444289 no 3274 0.0187568489155805 4742 1148199
SGTC_575 k072-0246 11.9 µM -2.082840428619 0.0154615454866687 no 3275 0.0186328855481843 4754 6796779
SGTC_3307 9126885 69.2785 µM -2.09413371604285 0.015013417527597 no 3276 0.0181240351802659 4674 24824909
SGTC_86 0417-1630 471.922 µM -2.10575676301618 0.0145639072343522 no 3277 0.0176127431730968 4722 3634867
SGTC_355 1311-2252 105 µM -2.11136842449242 0.0143510598219927 no 3278 0.0173703284477505 4673 5338538
SGTC_590 k048-0076 22.4 µM -2.11903003744354 0.0140647875858373 no 3279 0.0170439642662416 4727 6832814
SGTC_606 k015-0008 38.6 µM -2.12943415409012 0.0136839313017644 no 3280 0.0166091786175152 4736 1970475
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -2.13174488535893 0.01360056197883 no 3281 0.0165139123560514 4731 165521
SGTC_1843 st055809 45.5 µM -2.13436319831987 0.0135066254478606 no 3282 0.0164065308264721 4730 16413835
SGTC_3196 9111891 49.47 µM -2.13483141385428 0.0134898865660739 no 3283 0.0163873916491455 4687 18891510
SGTC_3324 9138759 60.749 µM -2.13504516340646 0.0134822508949137 no 3284 0.0163786605982666 4703 45595710
SGTC_295 k015-0027 31 µM -2.13993467587487 0.0133086012931412 no 3285 0.0161800231447805 4738 3887424
SGTC_219 mitoxanthrone 164.414 µM -2.14117845758851 0.013264738188413 no 3286 0.0161298247888112 4700 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_957 1187-1561 14.1 µM -2.14257634555215 0.0132155894913557 no 3287 0.0160735661202846 4661 1538454
SGTC_2866 9034245 58.44 µM -2.16075138835488 0.0125907514353543 no 3288 0.015357274494485 4733 6462273
SGTC_3031 9088762 49.47 µM -2.19594141323114 0.0114533517949429 no 3289 0.0140480685222846 4727 205253
SGTC_379 3970-0972 5.9 µM -2.19871237279727 0.0113677051267001 no 3290 0.0139491903106697 4725 2898042 YBL034C STU1
SGTC_212 3807-4682 38.772 µM -2.20555017698405 0.0111587349349364 no 3291 0.013707755422205 4752 3125501 YBL034C STU1
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -2.21624501205731 0.010838587398598 no 3292 0.0133373633459438 4740 5106787 A p450 inhibitor.
SGTC_2886 9058944 51.95 µM -2.21901932583722 0.0107568564153657 no 3293 0.0132427048898836 4733 4949929
SGTC_1004 4084-0029 199 µM -2.22622189629622 0.0105471696610016 no 3294 0.0129996610003389 4724 716894 YLR208W SEC13
SGTC_1897 st060201 15 µM -2.23256219657108 0.0103655422795884 no 3295 0.0127889146926925 4722 611878
SGTC_1094 duloxetine 25.4 µM -2.23345056012207 0.010340312817704 no 3296 0.0127596235867503 4733 60834 A selective serotonin reuptake inhibitor.
SGTC_1649 st011737 51.3 µM -2.23493419802667 0.0102982969682182 no 3297 0.012710834510821 4725 1761035
SGTC_3238 9133470 49.47 µM -2.24133831389515 0.0101186393368437 no 3298 0.0125020844750674 4743 3534688
SGTC_917 harmaline 728.087 nM -2.26729862744715 0.00941808101479938 no 3299 0.0116859946329857 4675 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2705 st078069 42.8 µM -2.27472536008156 0.0092256342259108 no 3300 0.011461205096422 4733 1530061
SGTC_2422 chlorphenesin carbamate 384.24 µM -2.27825098491934 0.00913548667630788 no 3301 0.011355814080805 4689 2724 A muscle relaxant with antifungal properties.
SGTC_1581 himbacine 57.9 µM -2.31910996047036 0.00814569661326291 no 3302 0.0101945374154264 4753 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2115 tiliquinol 12.7705 µM -2.34605586201271 0.00754569410983132 no 3303 0.00948663179459266 4720 71208 A bioactive hydroxyquinoline.
SGTC_2900 5328528 85.29 µM -2.34964345704664 0.00746881988348879 no 3304 0.00939570068113721 4719 795359
SGTC_2869 9037858 32.47 µM -2.35031051971415 0.00745460252768756 no 3305 0.00937887763696432 4721 27187042
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.36628535090256 0.00712117405395903 no 3306 0.00898379493875965 4738 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_50 0929-0078 56.389 µM -2.3685393543412 0.00707520335842775 no 3307 0.00892924017493113 4667 1377751
SGTC_2200 6600604 21.907 µM -2.37527139198295 0.0069394578827125 no 3308 0.00876802567124364 4760 2904777
SGTC_3171 9103192 49.47 µM -2.38426859723226 0.00676162989209071 no 3309 0.00855655340475391 4777 13018434
SGTC_740 k014-0057 261 µM -2.41448183453232 0.0061935809233955 no 3310 0.00787880434651166 4749 4012779
SGTC_1833 st055984 71 µM -2.44128762752329 0.00572541629467505 no 3311 0.00731749668818764 4766 676288
SGTC_779 1360-0071 233 µM -2.44701345257115 0.00562958430782051 no 3312 0.00720227312587612 4752 7566
SGTC_2592 piperlongumine 83.33 µM -2.47524035064714 0.00517767221726495 no 3313 0.00665732687691835 4740 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2028 5153890 36.43 µM -2.51947910001943 0.00453416948238637 no 3314 0.00587643087188293 4758 2830968 YPR165W RHO1
SGTC_2957 9076800 11.52 µM -2.53102901126727 0.00437837552846825 no 3315 0.00568642207658595 4730 16459615
SGTC_433 pimozide 108 µM -2.54176434665754 0.00423787685779098 no 3316 0.00551472539290586 4725 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_745 0469-0705 296 µM -2.54645162584566 0.00417780683024631 no 3317 0.00544121466773233 4782 3486736
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -2.55123971525896 0.00411723240298721 no 3318 0.00536702340931149 4765 689007
SGTC_796 1234-0020 70.7 µM -2.56557248769438 0.0039405773911235 no 3319 0.00515028481022663 4742 46495034
SGTC_3291 9121177 71.43 µM -2.56985721966439 0.00388910158420964 no 3320 0.0050870218988812 4744 17015612
SGTC_2189 6047310 154.431 µM -2.59365345628275 0.00361403175757211 no 3321 0.00474810750826484 4779 711535
SGTC_2563 tomatine 8.54 µM -2.61546902579519 0.00337733506558047 no 3322 0.00445525013347493 4725 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1475 4092-1048 11.7 µM -2.61620272910242 0.00336962240489866 no 3323 0.00444568745691958 4771 2881759
SGTC_2015 5119600 184 µM -2.6367803365477 0.00315965890300191 no 3324 0.00418485053533844 4741 2828786
SGTC_2307 7538926 6.34 µM -2.64612436707063 0.0030682647365304 no 3325 0.00407099380349277 4735 96582
SGTC_36 0335-0881 14.2 µM -2.66486617975547 0.00289209314626174 no 3326 0.00385094821636524 4735 23828853
SGTC_2417 cerulenin 830 nM -2.67213264674208 0.00282627982473572 no 3327 0.00376854241374043 4762 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_838 0109-0203 71.4 µM -2.67736655599666 0.00277971592941862 no 3328 0.00371017022702145 4788 759422
SGTC_2197 6588183 93.1375 µM -2.69606588295484 0.00261895692571122 no 3329 0.00350818938510651 4797 884136
SGTC_2366 9070441 60.58 µM -2.760383571233 0.00212811808958851 no 3330 0.00288667662639527 4764 6837235
SGTC_124 0136-0217 7.121 µM -2.7679426307099 0.0020762812695474 no 3331 0.00282056923870892 4791 3976905
SGTC_2710 st078562 53.7235 µM -2.78416909047433 0.00196885605004832 no 3332 0.00268325246455148 4776 17250908
SGTC_2925 9010536 32.5 µM -2.79142319514689 0.00192248450173324 no 3333 0.00262384051381946 4744 2994177
SGTC_2706 st078239 82.5 µM -2.81068208395258 0.00180414723498099 no 3334 0.00247183036214456 4781 15434492
SGTC_1275 0867-0008 21.1 µM -2.84449573718265 0.00161229140925876 no 3335 0.00222408905205393 4785 3422836
SGTC_2173 5763948 167 µM -2.8524580091052 0.00156990750941308 no 3336 0.00216912718241851 4793 2867177
SGTC_2120 5538279 151.968 µM -2.92018227257303 0.00124842806141899 no 3337 0.00174913356126226 4789 2058197
SGTC_369 0957-0393 4.5 µM -2.9214932721419 0.00124284704326706 no 3338 0.00174178899676958 4767 6997992
SGTC_38 0929-0051 58.268 µM -2.93353133219494 0.00119265713876285 no 3339 0.00167564913499752 4770 1379719
SGTC_2283 7944793 200 µM -2.9899885214307 0.000981117965476862 yes 3340 0.00139493965431104 4774 2970533
SGTC_841 0251-0215 91.2 µM -3.05768962033222 0.000773072546626068 yes 3341 0.00111525236070521 4798 3888614
SGTC_2496 diffractaic acid 79.83 µM -3.14462783464704 0.000565449262649302 yes 3342 0.000831491189760402 4784 94870 An apoptosis inducer which activates caspases.
SGTC_1129 3453-1384 223 µM -3.16328289455346 0.000528226469575189 yes 3343 0.000780003297462012 4780 1084452
SGTC_3145 9085516 49.47 µM -3.16354008020214 0.000527729523155585 yes 3344 0.000779314443808747 4784 25236195
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -3.21425216559948 0.000437771336699241 yes 3345 0.000653923809352776 4776 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2109 5483026 200 µM -3.24757251974017 0.000386641562953011 yes 3346 0.000581969992123711 4798 759335
SGTC_2893 9048488 25.97 µM -3.35016011821144 0.000261937537666633 yes 3347 0.000403824295129235 4798 6467338
SGTC_3283 9109332 35.8195 µM -3.47873452062175 0.000158397235498198 yes 3348 0.000251893702693906 4770 17027281
SGTC_345 1362-0200 395 µM -3.60108935877246 9.66337313342098e-05 yes 3349 0.000158443314908604 4796 1419823
SGTC_2928 9011484 9.79 µM -3.61659562517475 9.06691818570679e-05 yes 3350 0.000149251537157847 4786 2994751
SGTC_2891 9063876 19.48 µM -3.63390557621474 8.44203506905546e-05 yes 3351 0.000139581531290569 4806 6472478
SGTC_1837 st055472 66.5 µM -3.70226550242104 6.34867829432385e-05 yes 3352 0.000106841415660748 4804 676091
SGTC_837 0091-0265 12.5 µM -3.76753768738088 4.81488921756029e-05 yes 3353 8.24328288315046e-05 4804 759367
SGTC_2963 9082507 9 µM -3.80227152865588 4.14869166900055e-05 yes 3354 7.16877326266057e-05 4802 16459611
SGTC_2964 9083345 53.42 µM -4.32794232596231 3.74803574632282e-06 yes 3355 7.52544332929413e-06 4797 17741579
SGTC_2291 7917025 104.35 µM -6.20384162042313 6.88404274333497e-11 yes 3356 2.75506201292051e-10 4806 2964612