SGTCid condition conc unit YEH2|YLR020C.score YEH2|YLR020C.strain.pval YEH2|YLR020C.strain.significant YEH2|YLR020C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1760 st045453 10.4495 µM 19.3183481768245 1.67528975118741e-94 yes 1 1.88253429083804e-83 8 3323419 YIL048W NEO1
SGTC_2651 TUB2.036 5 µM 13.5403574588979 1.78305883315229e-47 yes 2 4.51740984144626e-42 12 15992207 YFL037W TUB2
SGTC_1754 st042065 16.137 µM 12.9055070304297 2.60441438751019e-43 yes 3 2.09524074054716e-38 13 1126236 YIL048W NEO1
SGTC_1801 st050089 28.441 µM 11.7357939032532 3.71443868660041e-36 yes 4 4.17693762462474e-32 9 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1803 st050068 52.4 µM 11.5323392909201 5.56682517579723e-35 yes 5 4.5323322963101e-31 18 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2582 agaric acid 100 µM 11.4581739634567 1.47616085832192e-34 yes 6 1.0698930963298e-30 45 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_221 trifluoperazine 10.304 µM 11.4109839439566 2.73658571868315e-34 yes 7 1.84268336346738e-30 43 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2896 9052656 71.43 µM 11.1937170860445 4.54298958885709e-33 yes 8 2.18845940081881e-29 7 6469436
SGTC_1818 st052136 56.3 µM 7.27902535997389 4.76441832656355e-15 yes 9 1.68120239161161e-13 6 674169
SGTC_1800 st050079 29.0735 µM 6.76607411856418 3.0525321161268e-13 yes 10 6.61618877706691e-12 28 3645560
SGTC_2249 haloperidol 116.36 µM 6.75680521433531 3.28193070776438e-13 yes 11 7.05338172893208e-12 34 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1597 7-benzyloxygramine 47.5 µM 6.53865788260502 1.75680494339119e-12 yes 12 3.1036667536596e-11 44 260807
SGTC_1750 st081859 2.357 µM 6.51757257136255 2.06026232976184e-12 yes 13 3.57271269453035e-11 96 5291695
SGTC_312 4092-0653 6.84 µM 5.93486818964238 1.38361011458242e-10 yes 14 1.47040832409008e-09 40 1148278
SGTC_2021 4019055 173 µM 5.7136259023304 6.19006304465807e-10 yes 15 5.52969905990047e-09 45 44827708 YER133W GLC7
SGTC_2250 alverine citrate 130 µM 5.6307821167617 1.06969219335007e-09 yes 16 8.9697119533175e-09 67 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1719 st032227 49.2 µM 5.6154817604975 1.1824206243958e-09 yes 17 9.80076669409014e-09 6 3125804
SGTC_649 1123-0311 367 µM 5.44418050835916 3.56643432377828e-09 yes 18 2.60222118328823e-08 32 693629 YIL048W NEO1
SGTC_207 4185-0010 4.486 µM 5.3856071203617 5.16337350746238e-09 yes 19 3.61002593672862e-08 51 3761753
SGTC_377 3970-0964 33.1 µM 5.12690937479875 2.52892821940372e-08 yes 20 1.47268601835059e-07 26 16481235
SGTC_528 3492-0019 172 µM 5.04810082290579 4.0433737891065e-08 yes 21 2.23111827543997e-07 155 2869262
SGTC_1679 SEC14.276 6.7 µM 4.65755089182294 3.73940811264182e-07 yes 22 1.59996667787024e-06 45 1005053 YMR079W SEC14
SGTC_813 k007-0158 173 µM 4.51315605380829 8.156437177424e-07 yes 23 3.19349954053543e-06 30 6523916
SGTC_3063 1327-0034 4 µM 4.49093280175118 9.17792447679674e-07 yes 24 3.54559615297651e-06 35 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1652 st011932 78 µM 4.37640692471515 1.67145100274284e-06 yes 25 6.03258380849918e-06 8 1551076
SGTC_1139 k015-0024 46.9 µM 4.21680372374928 3.76272299353853e-06 yes 26 1.23894735492598e-05 9 2766652
SGTC_3327 9140648 26.9345 µM 4.17005109919304 4.74723449817888e-06 yes 27 1.52265674553487e-05 8 8029710
SGTC_2790 5423970 71.43 µM 4.13615790160068 5.61005322766015e-06 yes 28 1.76584608597059e-05 62 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2407 paclitaxel 400 µM 4.09051756326637 7.01082906391369e-06 yes 29 2.15205807005384e-05 33 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_513 4245-1575 41.7 µM 4.03719825114253 9.07001737347457e-06 yes 30 2.7046677214834e-05 111 719745
SGTC_3148 9097893 49.47 µM 3.94895111711958 1.37959308306213e-05 yes 31 3.92471886335784e-05 38 17174100
SGTC_514 4466-0038 2.65 nM 3.94289644944756 1.41942622792453e-05 yes 32 4.02517100645985e-05 159 5722064
SGTC_320 4092-0846 5.34 µM 3.92654792428651 1.53251603974355e-05 yes 33 4.30868643622398e-05 48 1359356
SGTC_445 e6 berbamine 66 µM 3.7278341178272 3.80169499459826e-05 yes 34 9.65662126825982e-05 123 6610268 A calcium/calmodulin antagonist.
SGTC_2563 tomatine 8.54 µM 3.68400136482414 4.61856628525844e-05 yes 35 0.000114800504886384 60 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_535 2293-4129 48.2 µM 3.6830240191048 4.63854369814279e-05 yes 36 0.000115241716591669 72 396118 YIL048W NEO1
SGTC_759 3486-0358 89.3 µM 3.54882388820872 8.30813596033297e-05 yes 37 0.000193477893559904 29 875103
SGTC_743 1275-0778 158 µM 3.53648529522552 8.75692461363383e-05 yes 38 0.000202744537000824 49 2849257 YMR203W TOM40
SGTC_3059 1327-0034 3 µM 3.41209355941607 0.000147472069824271 yes 39 0.000322329915116951 72 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2612 dictamnine 15.46 µM 3.40481900805918 0.000151957903749819 yes 40 0.000331039596241105 68 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2469 5655019 90.81 µM 3.38420458314933 0.000165373638323329 yes 41 0.000356923957093747 36 2788239
SGTC_769 0302-0231 76 µM 3.36414048295769 0.000179488943023468 yes 42 0.000383912243847035 78 571869 YER009W NTF2
SGTC_1319 1306-0155 43.7 µM 3.36280624963489 0.000180466451909629 yes 43 0.000385772469510266 56 3122360
SGTC_2257 7960413 200 µM 3.3595747528784 0.000182854633939811 yes 44 0.000390312645862792 84 2974689 YIL048W NEO1
SGTC_2286 7945697 125 µM 3.33864035209942 0.000199056016716249 yes 45 0.000420947438249644 80 1245733
SGTC_776 4476-4378 112 µM 3.32930384260289 0.000206705802326204 yes 46 0.000435316838733487 40 2892008
SGTC_201 4262-0159 12.803 µM 3.32448489742045 0.000210760762791848 yes 47 0.000442910155407289 69 1341029
SGTC_882 0843-0131 351 µM 3.32245883134056 0.000212487701559868 yes 48 0.000446139185684911 33 5425421
SGTC_1717 st033143 58.0435 µM 3.30538088083748 0.000227578284023701 yes 49 0.000474237057221026 74 674616
SGTC_1687 st020778 55.3625 µM 3.28816137914361 0.000243801920195667 yes 50 0.000504220079105133 210 4259299
SGTC_767 0929-0023 86 µM 3.25213429886459 0.000281294274295337 yes 51 0.000572709435553138 135 1204563
SGTC_1712 st032288 53.4 µM 3.2441220235216 0.000290331926891848 yes 52 0.00058906631874549 238 2883011
SGTC_2474 5321570 43.32 µM 3.18866819971838 0.000360686444400547 yes 53 0.000714649153903443 39 2841384
SGTC_2600 tangeritin 87.95 µM 3.12113257258796 0.000467698402023129 yes 54 0.000900784549771809 67 68077 A bioactive flavone.
SGTC_3259 9138485 49.47 µM 3.11134042258176 0.000485456733871293 yes 55 0.000931200514869513 38 17646153
SGTC_1291 0993-0025 5.79 µM 3.09658494668634 0.000513398584366478 yes 56 0.000978818815883072 33 4353356
SGTC_376 3970-0862 59.1 µM 3.09429844207067 0.000517859320536064 yes 57 0.000986394648458751 54 3135186
SGTC_2619 obliquin 87.91 µM 3.0883262660944 0.000529680159400134 yes 58 0.00100643674266692 209 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1411 3909-8223 150 µM 3.07596768173906 0.00055493855396188 yes 59 0.00104910293093012 36 X1411
SGTC_262 fenpropimorph 62.5 µM 3.05420990604769 0.00060213073660404 yes 60 0.00112827066856376 59 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_874 0599-0792 117 µM 3.05398091064427 0.000602646572541355 yes 61 0.00112913224977024 71 765305
SGTC_2093 5331342 194.4 µM 3.03760618494762 0.000640608526564741 yes 62 0.00119232686371981 55 33839
SGTC_1115 galangin 695.678 nM 3.03187644804801 0.000654405022121981 yes 63 0.00121519329975666 52 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2905 7799065 20.05 µM 3.02269173521987 0.000677093844967498 yes 64 0.00125268656826072 41 1296806
SGTC_313 3474-0040 5.03 µM 3.02107672579412 0.00068115760473933 yes 65 0.00125938763193575 135 1043375 YIL048W NEO1
SGTC_178 4092-0806 87.505 µM 2.99460127172186 0.00075106559968285 yes 66 0.0013740190673788 162 2169044
SGTC_1270 0831-1170 17.3 µM 2.98632393329949 0.000774242275900668 yes 67 0.00141176688271913 47 6764716
SGTC_2073 5212005 126 µM 2.96753466649929 0.000829317297855996 yes 68 0.00150099214019186 28 691789
SGTC_945 3381-0768 11.3 µM 2.94504536161651 0.000899968345303867 yes 69 0.00161453658826074 80 1126236 YIL048W NEO1
SGTC_1019 4262-0212 3.4 µM 2.93566907065702 0.000931025901232604 yes 70 0.00166414590919171 139 4677213
SGTC_266 formosanin C 406 nM 2.92269017770923 0.000975642618024103 yes 71 0.00173510813689057 134 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2949 9072542 2.23 µM 2.91939129571541 0.000987291651700776 yes 72 0.00175357844156795 100 16457352
SGTC_619 1652-1634 108 µM 2.91796303628548 0.000992374623517776 yes 73 0.00176163056394666 70 5400454
SGTC_733 4069-0007 56.1 µM 2.82695104858231 0.00137041305528378 no 74 0.00234967554803526 171 5717425 YNL287W SEC21
SGTC_763 3453-1109 128 µM 2.81810327072068 0.00141343422772717 no 75 0.00241541347437268 72 1560353
SGTC_3034 9090421 49.47 µM 2.81129596965885 0.00144736936265598 no 76 0.00246711870026979 41 17173761
SGTC_1103 duloxetine 36.1 µM 2.7855538961256 0.00158252717203911 no 77 0.0026718177904963 101 60835 A selective serotonin reuptake inhibitor.
SGTC_1058 3448-5425 97.3 µM 2.77889952504168 0.00161928874885285 no 78 0.0027271696576794 90 7279705
SGTC_1061 3448-9325 110 µM 2.77025466553114 0.00166820840421556 no 79 0.00280062395756552 76 723482
SGTC_780 0109-0199 192 µM 2.74155155543897 0.00184044241982675 no 80 0.00305748817875257 89 610414
SGTC_2000 st075254 36.4 µM 2.72544626589706 0.00194401741423195 no 81 0.00321073139438924 55 17234175
SGTC_2036 5160441 105 µM 2.71479876354507 0.00201537088591215 no 82 0.00331580268405568 154 134534 YIL048W NEO1
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.70905671058948 0.00205482995914398 no 83 0.0033737402658006 149 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_439 amiodarone 34.4 µM 2.66370880205153 0.00239194140434889 no 84 0.00386422158958694 189 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1211 1056-0033 32.3 µM 2.65571417103478 0.00245631563337862 no 85 0.00395703308629759 58 6741922
SGTC_3162 9099653 49.47 µM 2.64573198824819 0.00253889211315088 no 86 0.00407571858492222 53 25237511
SGTC_1106 tegaserod maleate 11.7 µM 2.6361003605091 0.00262093910431863 no 87 0.00419324615655302 116 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_773 4358-1457 44.6 µM 2.62387767324286 0.00272850365377619 no 88 0.00434675010637514 135 1186886
SGTC_819 1013-0258 27.7 µM 2.59162086851216 0.0030317702779958 no 89 0.00477624896303337 120 5753198
SGTC_218 alverine citrate 93.75 µM 2.58337354982955 0.0031140316134222 no 90 0.00489196626004781 96 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1213 1315-0166 115 µM 2.58087629436904 0.00313933338740771 no 91 0.0049274944326005 108 768401
SGTC_1649 st011737 51.3 µM 2.56047710415127 0.00335304416985682 no 92 0.00522642754441079 78 1761035
SGTC_1991 st073000 8.92 µM 2.55163592645195 0.00344966386606999 no 93 0.00536092461309162 177 4301969 YIL048W NEO1
SGTC_788 1182-0090 188 µM 2.54306332972006 0.0035457292896158 no 94 0.00549426553600597 208 5715185
SGTC_872 0588-0139 234 µM 2.53698222780641 0.00361532387067778 no 95 0.00559063151293733 135 2047100
SGTC_2047 4141938 200 µM 2.53412115433953 0.00364848924400537 no 96 0.00563648743265495 70 3807862
SGTC_99 0109-0120 622.8 µM 2.53380422656727 0.00365217979360841 no 97 0.00564158749075256 94 759414
SGTC_1644 st010134 20.9 µM 2.51777639732835 0.00384324452114659 no 98 0.00590491341364991 76 3818134
SGTC_875 0709-0210 25.7 µM 2.51269689358414 0.00390563909523796 no 99 0.00599061131605719 123 6251364
SGTC_3185 9108267 49.47 µM 2.50884255009379 0.00395358826570874 no 100 0.00605637307001898 130 4910486
SGTC_2985 9022375 71.43 µM 2.5046794446879 0.00400597021784207 no 101 0.00612812082036158 139 4939335
SGTC_568 1193-0097 7.48 µM 2.48804834574649 0.00422148407491892 no 102 0.0064223135406575 274 3646150
SGTC_1661 st013063 9.66 µM 2.4879767870113 0.00422243334947395 no 103 0.00642360590942222 119 721395
SGTC_1556 plumbagin 1.48 µM 2.45320649107542 0.00470690467151817 no 104 0.00707945174115004 88 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_683 panaxydol 45 µM 2.44730224022899 0.00479392585672161 no 105 0.00719650433565414 122 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_794 k038-0031 316 µM 2.40366461222581 0.00548281969794677 no 106 0.00811582867552117 230 6624242
SGTC_1836 st055642 81 µM 2.39022867074354 0.00571196055242283 no 107 0.00841894273069894 163 8571
SGTC_2435 5706476 10.6 µM 2.37744880143066 0.00593775990897791 no 108 0.00871643144082605 147 5725375
SGTC_68 0986-0284 82.829 µM 2.36866432492406 0.00609752315732643 no 109 0.00892622396062223 215 423278 YIL048W NEO1
SGTC_1979 st071809 45.3 µM 2.35678297501176 0.00631966484839805 no 110 0.00921700836454085 116 4976333
SGTC_163 TUB2.036 7.546 µM 2.34726696531678 0.00650271878602031 no 111 0.00945584952407437 309 15992207 YJR013W GPI14
SGTC_658 3253-0951 102 µM 2.33856446373458 0.00667421340246111 no 112 0.00967899287889091 215 1184878
SGTC_3060 1327-0027 12.5 µM 2.33722435348198 0.0067009742925954 no 113 0.00971376075414918 134 16000455 YPR107C YTH1
SGTC_558 k064-0027 21.3 µM 2.33578996804297 0.00672972281056045 no 114 0.00975109536360512 144 5088526
SGTC_3218 9131285 49.47 µM 2.33117805354996 0.00682289655621669 no 115 0.00987198643854266 204 17156417
SGTC_2067 5224629 34.075 µM 2.32317470253267 0.00698729383580818 no 116 0.0100848845954515 146 2835000
SGTC_3149 9097855 49.47 µM 2.31354811007569 0.00718965899858661 no 117 0.0103462614229283 140 25236625 YMR079W SEC14
SGTC_3166 9102297 49.47 µM 2.31000197953262 0.00726549655642133 no 118 0.0104440222655112 174 25237072
SGTC_2799 7812892 81.82 µM 2.30922016745016 0.00728231097833851 no 119 0.0104656835020752 159 20205235
SGTC_1059 3448-6867 171 µM 2.29059642180988 0.0076931235626619 no 120 0.0109933830417199 127 3934407
SGTC_2796 7949634 45.45 µM 2.28893817986825 0.00773067245542509 no 121 0.0110414722626912 154 2971588
SGTC_2426 5582046 32.21 µM 2.28676408042042 0.00778014663428122 no 122 0.0111047985620566 172 2251934
SGTC_3143 9086658 49.47 µM 2.26704072088073 0.0082418538287293 no 123 0.011693869132951 215 25236626
SGTC_3287 9117173 37.0625 µM 2.25953044467612 0.00842389072109741 no 124 0.011925204361176 85 2789709
SGTC_2533 agelasine 13.65 µM 2.24771235298726 0.00871749072238437 no 125 0.0122972688992435 205 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2625 euphol 100 µM 2.24134185745483 0.00887944654461178 no 126 0.0125019697950449 184 6708538 A triterpene alcohol.
SGTC_1829 berberine 14.4 µM 2.22000974375591 0.00944112180311485 no 127 0.0132090531003211 146 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_916 4466-0038 42 nM 2.20867783042268 0.00975194348369155 no 128 0.0135985287554766 267 5722064 YGL116W CDC20
SGTC_1911 st060208 74.3 µM 2.19608793170885 0.0101077190722493 no 129 0.0140428251083651 188 688783
SGTC_3282 9108498 15.4605 µM 2.19431763137583 0.0101586430751628 no 130 0.0141062913940163 180 16459645
SGTC_2156 5649887 115 µM 2.17870579028675 0.0106175038131872 no 131 0.0146767656714481 189 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1206 3978-0017 132 µM 2.17223858285103 0.0108128128227675 no 132 0.0149188359355173 178 3873677
SGTC_2606 farnesol 9.78 µM 2.16709410655437 0.0109704015792586 no 133 0.0151138396068531 174 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1151 3909-8316 15.3 µM 2.16099990250281 0.0111596653646865 no 134 0.0153476734732065 180 800431
SGTC_2079 5212404 121 µM 2.15818870860217 0.0112479234962396 no 135 0.0154565814677163 138 758462
SGTC_2584 androsterone 48.74 µM 2.1387336442884 0.0118755146200191 no 136 0.016228623093677 349 2754130 A steroid.
SGTC_75 0159-0059 199.013 µM 2.1301370590994 0.0121623664938915 no 137 0.0165801497741265 176 5377270
SGTC_3311 9131146 2.8755 µM 2.12641759329466 0.0122883276321359 no 138 0.0167342520712363 279 4900406 YPR165W RHO1
SGTC_278 4092-0821 23.9 µM 2.10457977579391 0.0130509073628983 no 139 0.0176639518093497 197 877900
SGTC_2987 9018338 71.43 µM 2.10456865570773 0.0130513058695294 no 140 0.0176644362299172 215 5055682
SGTC_1140 3229-1848 2.98 µM 2.09925556383446 0.0132429164197801 no 141 0.0178971891464802 141 2849525
SGTC_1282 0886-0010 32.4 µM 2.09354163378552 0.0134516902351102 no 142 0.018150415782737 216 2836211 YNL267W PIK1
SGTC_237 nikkomycin 200 µM 2.09316800915079 0.0134654400544632 no 143 0.0181670797031033 194 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2699 st077704 54.6 µM 2.08927554779476 0.0136094103284794 no 144 0.0183414631005444 233 645852
SGTC_1432 4049-0298 68.4 µM 2.07824029016669 0.0140248139830061 no 145 0.0188436164533428 160 741646
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.06783587811044 0.0144264343335911 no 146 0.019327729342773 264 368090
SGTC_2285 7945142 200 µM 2.06783130011364 0.0144266132055438 no 147 0.0193279446595646 209 2970608
SGTC_1254 0550-0035 264 µM 2.06282194744436 0.0146234867965163 no 148 0.0195647740067548 210 15121435
SGTC_866 0495-0101 262 µM 2.06269789688819 0.0146283913221435 no 149 0.019570669931636 193 635694
SGTC_556 4058-0063 51.5 µM 2.03265656405568 0.0158585623553959 no 150 0.0210436162587989 214 6615692
SGTC_2275 7947463 200 µM 2.02482624924771 0.0161934196853259 no 151 0.021442604351187 190 1225414
SGTC_1138 3761-0006 1.03 µM 2.00741055099768 0.0169599661782855 no 152 0.0223529831472451 158 12061087
SGTC_270 tamoxifen 5.46 µM 1.97995429322038 0.0182313953428262 no 153 0.0238543324081954 245 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1728 st035614 33.7865 µM 1.97310660664254 0.0185608625568893 no 154 0.0242417088679329 317 15945546
SGTC_1520 flindersine 88 µM 1.97274871082069 0.0185782207410212 no 155 0.0242620996237632 238 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2812 7970281 58.44 µM 1.97214500592565 0.0186075321467734 no 156 0.0242965277447272 265 2233435
SGTC_1612 st002233 45.4 µM 1.96242520640726 0.0190848995843803 no 157 0.0248565002541464 227 1035021
SGTC_1711 st032263 62.8 µM 1.95486509637407 0.019463361694138 no 158 0.0252994976229323 209 3958979
SGTC_548 1436-0017 110 µM 1.9490277241929 0.0197599274138557 no 159 0.0256460569658482 287 9677137
SGTC_1335 1486-0900 202 µM 1.92184922524487 0.0211917160520798 no 160 0.0273123661507084 285 X1335
SGTC_1510 1123-0200 71.5 µM 1.9196173764978 0.0213130956111487 no 161 0.0274531237664651 315 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1482 3346-2049 8.48 µM 1.91205816548388 0.0217285813827805 no 162 0.0279343669603483 229 3826804
SGTC_1450 4112-4260 37.6 µM 1.91079511135439 0.0217986669857306 no 163 0.02801545810182 251 1633175
SGTC_1804 st050076 49.1 µM 1.90008336406882 0.0224007628570489 no 164 0.0287110902478882 245 3895976
SGTC_2032 5185112 25.99 µM 1.88519485444414 0.0232608789365384 no 165 0.0297017676406332 208 5718189
SGTC_1347 1493-0251 600 nM 1.88319827667216 0.0233783089834179 no 166 0.0298367512584335 266 3986378
SGTC_113 0099-0221 2.5 µM 1.88042990583196 0.0235419576353738 no 167 0.0300247554810091 246 89219
SGTC_2950 9072895 21.46 µM 1.87837786559682 0.0236638822696843 no 168 0.0301647456560853 329 17332245
SGTC_505 gw-5074 63.9 µM 1.867125974296 0.024341904660789 no 169 0.0309419989796345 279 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2307 7538926 6.34 µM 1.84655347616445 0.0256237604853276 no 170 0.0324059411169202 317 96582
SGTC_3106 9121286 49.47 µM 1.84308710900991 0.0258452151195867 no 171 0.0326581465860739 242 15943471
SGTC_2430 5571206 200 µM 1.83962777841955 0.0260678146355018 no 172 0.0329114516172627 316 1731771
SGTC_105 0111-0055 734.78 µM 1.829112161746 0.026754335913873 no 173 0.0336914037135159 209 5179370
SGTC_164 4100-3994 89.624 µM 1.82826413420099 0.0268103520291974 no 174 0.0337549599090352 341 4615967
SGTC_825 1988-2224 89.6 µM 1.82194102170588 0.027231117417331 no 175 0.0342319675403378 305 1180859
SGTC_600 1495-0418 41.6 µM 1.81046873173714 0.028008593969231 no 176 0.0351115645276086 265 5377768
SGTC_628 1636-0253 16 µM 1.80620821694238 0.0283019973647707 no 177 0.0354429109563748 317 4456143
SGTC_804 1595-0054 20.9 µM 1.80412164866099 0.0284466209138169 no 178 0.0356061193192036 280 761523 Stimulates phospholipase C.
SGTC_878 0828-0289 13.7 µM 1.79499670514027 0.0290863290240772 no 179 0.0363271124471353 368 745350 YLR208W SEC13
SGTC_1322 1348-1070 12 µM 1.79298017336294 0.0292292997932173 no 180 0.0364880471894256 226 6758089
SGTC_2526 patulin 37.61 µM 1.79275334368192 0.0292454183282909 no 181 0.0365061863885972 401 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_935 2996-0153 430 µM 1.79134684245956 0.0293455293120778 no 182 0.0366188267812201 269 23738523
SGTC_1209 2323-2347 50.3 µM 1.79106065478351 0.029365934186931 no 183 0.036641781048225 249 5412760
SGTC_2737 bleomycin 30.5 nM 1.79058468131855 0.0293998966759392 no 184 0.0366799835375948 350 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1976 st070609 63.5 µM 1.7846770717099 0.0298241477649574 no 185 0.0371568560317395 284 682556
SGTC_2638 epoxomicin 18 µM 1.78016737044023 0.0301514165224987 no 186 0.0375242868375721 306 9915668 A protesome inhibitor.
SGTC_2464 5717415 7.67 µM 1.76901130754756 0.0309738196757865 no 187 0.0384459937927167 308 5285744
SGTC_2702 st077768 96.8 µM 1.76132581389584 0.03155111033935 no 188 0.039091636676748 284 6484119
SGTC_106 0092-0003 11.579 µM 1.76094972460945 0.0315795867612186 no 189 0.0391234563558173 220 1072148
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.76037863072476 0.0316228689984553 no 190 0.0391718150459556 276 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1143 3454-2408 5.08 µM 1.75741347473726 0.0318483819047322 no 191 0.0394236791043926 214 X1143
SGTC_3228 9131799 49.47 µM 1.75403402613511 0.0321070216757718 no 192 0.0397123384776128 270 17015818
SGTC_152 4469-0003 551.229 µM 1.75131091725864 0.0323166891527426 no 193 0.039946184105158 286 697280
SGTC_1237 0330-0133 46.1 µM 1.74913274865542 0.0324852108328171 no 194 0.0401340377838257 286 X1237 YHR072W ERG7
SGTC_955 1216-0110 33 µM 1.74812721419345 0.0325632517727229 no 195 0.0402210007741535 391 3619719
SGTC_2077 5212015 200 µM 1.73187868016835 0.0338459043333122 no 196 0.0416475827180797 331 780900
SGTC_2724 maprotiline 69.64 µM 1.72695844040345 0.0342424056982399 no 197 0.0420875638032195 276 4011 A tricyclic antidepressant.
SGTC_268 camptothecin 39.6153 µM 1.72493595162307 0.0344064930649727 no 198 0.0422695078207674 438 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1739 st037196 92.5 µM 1.71809045988629 0.0349666781515747 no 199 0.0428900583385476 317 612214
SGTC_1678 st019265 80.2 µM 1.71751231650357 0.0350143300443433 no 200 0.0429428030016706 360 5367020
SGTC_2118 5526350 200 µM 1.71545347104742 0.0351844577821832 no 201 0.0431310595581645 332 743594
SGTC_2313 7726885 200 µM 1.71407333276395 0.0352988814153456 no 202 0.0432576293458165 324 726423
SGTC_2336 9001819 198.65 µM 1.71235060634422 0.0354421362132237 no 203 0.0434160379064523 373 2989602
SGTC_1980 st071811 45.7 µM 1.71036363593992 0.0356079560973089 no 204 0.0435993255119358 296 4974850
SGTC_1573 oleylamine 1.06 µM 1.70731522241167 0.0358635930562378 no 205 0.0438817391202445 333 5356789 An amine of the fatty acid oleic acid.
SGTC_838 0109-0203 71.4 µM 1.70115684997516 0.0363846155505911 no 206 0.0444567690259949 312 759422
SGTC_3177 9107506 49.47 µM 1.69747377621557 0.03669916747638 no 207 0.0448035624248734 246 8897194
SGTC_2324 6149169 200 µM 1.69673376640117 0.0367626353932544 no 208 0.0448735028879886 293 2888231
SGTC_95 0471-0001 561.058 µM 1.69538525080513 0.0368785234340735 no 209 0.0450011810053489 340 4015405
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.69269241566253 0.0371108326942452 no 210 0.0452570148325985 191 1241132 A phosphatase inhibitor.
SGTC_1758 st042942 75.2445 µM 1.68386289457935 0.0378809526114769 no 211 0.046104084388335 302 669317
SGTC_1618 st003135 44.5 µM 1.68195713778016 0.0380488742455738 no 212 0.0462885758457926 286 1270615
SGTC_1343 1487-0095 224 µM 1.67070316520815 0.0390529136820418 no 213 0.0473901616856919 306 4560101 YGL055W OLE1
SGTC_1293 1000-1278 195 µM 1.6698942234687 0.0391259078408049 no 214 0.0474701467203497 363 678847
SGTC_1430 4049-0248 69.1 µM 1.65823560839878 0.0401902998425489 no 215 0.0486349600725576 383 22774488
SGTC_1332 1480-0653 17.5 µM 1.64834280556696 0.0411118198690317 no 216 0.0496411727317569 355 5749438
SGTC_2098 5376439 882.5 nM 1.64679874521848 0.0412571837512452 no 217 0.0497997096870827 366 2844116
SGTC_1831 st055328 12 µM 1.63580978979805 0.0423038005482259 no 218 0.0509397012438014 361 1103068
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.63433568752505 0.0424458177219532 no 219 0.051094192058528 342 6708514
SGTC_1108 betulinic acid 729.144 nM 1.62417648645473 0.043435086641765 no 220 0.0521690738427614 350 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2521 angolensin 13.4 µM 1.6231270607212 0.0435383282602676 no 221 0.0522811229658371 317 821428 A flavenoid.
SGTC_2848 9016370 25.97 µM 1.62060038021422 0.0437877135877395 no 222 0.0525516853248914 409 7894410
SGTC_2970 9090938 41.86 µM 1.61732653742657 0.0441125569759741 no 223 0.0529039069479991 455 17217104
SGTC_1041 0206-0046 107 µM 1.61494804260282 0.0443497768397122 no 224 0.0531609735276828 354 50494
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.6108475637274 0.0447611522907677 no 225 0.0536064756326075 360 6710655
SGTC_1096 rimcazole 32.2 µM 1.60932347864529 0.044914835307218 no 226 0.0537728139034371 318 18528119 A dopamine reuptake inhibitor.
SGTC_3091 9116372 49.47 µM 1.60813793708571 0.0450346743512081 no 227 0.0539024860448892 347 17169793
SGTC_2928 9011484 9.79 µM 1.60788415094642 0.0450603614294696 no 228 0.0539302768066112 337 2994751
SGTC_3299 9121982 43.1275 µM 1.60747201505807 0.045102101070339 no 229 0.0539754317693167 377 17594604 YPL160W CDC60
SGTC_3040 9091894 49.47 µM 1.60538801533344 0.0453136377379841 no 230 0.0542042201161882 294 25236966
SGTC_956 1185-0240 191 µM 1.60458838898661 0.0453950154783459 no 231 0.0542922091768716 360 1416193
SGTC_973 1325-0077 65.9 µM 1.59941690578398 0.0459241579908655 no 232 0.0548639991727789 396 2835149
SGTC_2166 5933061 31.504 µM 1.59643490893597 0.0462315194735277 no 233 0.05519586371422 381 2877375
SGTC_700 3453-2283 142 µM 1.59585315592036 0.0462916742740073 no 234 0.0552607911055039 421 565664
SGTC_1562 morin hydrate 59.1 µM 1.59574566611541 0.046302795879964 no 235 0.055272794261235 368 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1405 3909-7894 12 µM 1.59220233411904 0.0466706149737087 no 236 0.0556696244772083 361 7104060
SGTC_3039 9090270 49.47 µM 1.58948344966638 0.0469544381216936 no 237 0.0559756438263431 330 17173750
SGTC_3318 9139014 38.6185 µM 1.58702637804213 0.0472121198638018 no 238 0.0562533352574828 340 16643984
SGTC_2346 9031566 143.75 µM 1.58119566235871 0.0478281449127048 no 239 0.0569166534300263 345 4771086
SGTC_1672 st016598 6.51 µM 1.57872279300359 0.0480913437123524 no 240 0.0571998271908589 416 4665860 YNL267W PIK1
SGTC_1470 k295-0292 231 µM 1.57383675797671 0.0486147937046453 no 241 0.0577625968419453 389 5045612
SGTC_397 arbidol 50 µM 1.57071444662127 0.0489516713375929 no 242 0.0581244960005162 398 131410 A RNA synthesis inhibitor.
SGTC_1210 3013-0140 750 nM 1.57061198731322 0.0489627575751367 no 243 0.0581364019201178 370 905973
SGTC_234 nsc-17383 10.7 µM 1.57059708482341 0.048964370212043 no 244 0.0581381337705706 446 408974
SGTC_3219 9131112 49.47 µM 1.57049502766059 0.0489754152216165 no 245 0.0581499951427649 370 17612988 YMR079W SEC14
SGTC_1493 4348-0038 111 µM 1.56858510168531 0.0491824820034678 no 246 0.0583723230709216 417 800424
SGTC_1320 1313-0481 95.3 µM 1.56685929629164 0.0493701879142623 no 247 0.0585737918277672 380 6813365 YLR208W SEC13
SGTC_2681 menadione 3.18 µM 1.56292145235772 0.0498006259392184 no 248 0.0590355355801647 382 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2483 5729050 27.16 µM 1.56182385486117 0.049921134183727 no 249 0.0591647452407505 485 2865180
SGTC_321 4534-3890 65.3 µM 1.55177253253575 0.0510355434688215 no 250 0.0603583302034451 365 699746
SGTC_2794 7785382 27.27 µM 1.54844076996268 0.0514092813190054 no 251 0.0607581058654092 488 2205081
SGTC_1364 1653-0028 37.6 µM 1.53956970963541 0.0524150050079245 no 252 0.0618326368193896 411 5718652
SGTC_2739 tacrine 100.86 µM 1.53750819321972 0.0526509441320167 no 253 0.0620844551132829 348 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.53546568026546 0.0528855387232123 no 254 0.06233474050134 423 1273210
SGTC_2456 5770359 74.46 µM 1.53361307754808 0.0530990373768962 no 255 0.062562434567185 375 3118787
SGTC_38 0929-0051 58.268 µM 1.52818012815754 0.0537290867566564 no 256 0.0632339106154344 446 1379719
SGTC_2375 9072683 200 µM 1.52763794703408 0.0537922860923265 no 257 0.0633012273317784 442 16798029
SGTC_2816 7982706 58.44 µM 1.51786003038934 0.0549421832856611 no 258 0.0645248439544878 424 2981853
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.51620003447293 0.0551393160801615 no 259 0.0647343896804548 455 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1874 staurosporine 7.6 µM 1.51585634772635 0.0551802003303075 no 260 0.0647778401369197 427 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1229 0139-0193 12.2 µM 1.51358453768855 0.0554510526526518 no 261 0.0650656226124881 438 3090752
SGTC_3211 9128781 49.47 µM 1.50940916547336 0.0559515900250201 no 262 0.0655971261324376 441 17194361
SGTC_468 gf-109203x 121 µM 1.50765559477983 0.0561628652819951 no 263 0.0658213480004242 267 2396 A protein kinase C inhibitor.
SGTC_934 2950-0684 338 µM 1.50659594450594 0.0562908396096381 no 264 0.0659571287821158 441 1121253
SGTC_97 0535-0701 19.132 µM 1.49926901541625 0.0571820158420876 no 265 0.0669019285498265 393 2832013 YGL099W LSG1
SGTC_394 menadione 8.33 µM 1.49835412442182 0.0572940698436192 no 266 0.0670206343750533 438 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_112 phenothiazine 287.218 µM 1.49803619351454 0.05733304981052 no 267 0.0670619235844153 421 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3240 9133527 49.47 µM 1.49758344491589 0.0573885951340761 no 268 0.0671207553153863 408 17617455
SGTC_567 1080-0542 68.4 µM 1.49699953534888 0.0574602944052672 no 269 0.0671966894793366 380 5950415
SGTC_2 0422-0095 29 µM 1.49544864409366 0.057651073211175 no 270 0.0673986966864692 313 6790840
SGTC_1664 st014217 9.02 µM 1.49483853824806 0.0577262601600364 no 271 0.0674782929193673 422 3982782
SGTC_2329 6138490 200 µM 1.48530406863193 0.0589112936677144 no 272 0.068731647294041 400 720019
SGTC_922 1866-0035 480 µM 1.48494180365912 0.0589566929812109 no 273 0.0687796204843106 503 3156169
SGTC_512 prima-1 270 µM 1.48345683967394 0.0591430766917979 no 274 0.0689765377289745 445 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_158 k038-0087 26.446 µM 1.47779488522993 0.0598579741988495 no 275 0.0697313439132844 567 X158
SGTC_33 0986-0033 35.816 µM 1.47693118305159 0.0599676207124912 no 276 0.0698470425376681 384 2848082
SGTC_1792 st045773 43.6 µM 1.4746340741856 0.0602600029505622 no 277 0.070155474457809 428 2919270
SGTC_2870 9038528 12.99 µM 1.47190750390705 0.0606084951477635 no 278 0.0705229284834697 400 6463316
SGTC_1892 st058411 7.36 µM 1.46159112526182 0.0619413508036831 no 279 0.0719266438974986 508 3934738
SGTC_426 0988-0037 14.6 µM 1.45764248060003 0.0624575199927895 no 280 0.0724695569978489 513 5383008
SGTC_863 0466-0191 129 µM 1.45556917940885 0.062729882681998 no 281 0.0727558766323727 509 765160 YPR165W RHO1
SGTC_2998 9066762 71.4286 µM 1.45148304158717 0.0632693738475531 no 282 0.0733227005298308 516 4945196
SGTC_1626 st003712 1.76 µM 1.45002857809274 0.0634622754819554 no 283 0.0735252750325473 420 24207035
SGTC_1871 st057448 67.3 µM 1.44923285897026 0.063568003145948 no 284 0.073636282019869 471 691747
SGTC_3335 9143315 29.6265 µM 1.44627455670555 0.0639622768969762 no 285 0.0740501045830966 440 4899691
SGTC_1757 st041620 31.8375 µM 1.44612131449782 0.0639827522518039 no 286 0.0740715891951434 447 5289815
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.44465005182065 0.0641795934808709 no 287 0.0742781031428757 507 23847180
SGTC_283 0987-0079 11.7 µM 1.44178015932155 0.0645649126488798 no 288 0.0746822008787693 500 411556
SGTC_941 3237-0776 460 µM 1.43632295402612 0.065302565737861 no 289 0.07545523268272 423 760008
SGTC_2384 9036245 200 µM 1.43318992600209 0.0657290032744288 no 290 0.0759017839054728 470 6462766
SGTC_1040 k898-0338 155 µM 1.43231316442094 0.0658487253476843 no 291 0.0760271086222806 500 20969351
SGTC_1555 citronellol 128 µM 1.43101718937469 0.0660260006084734 no 292 0.076212644369927 408 8842 A terpine precursor.
SGTC_2759 disulfiram 3.38 µM 1.4297480044717 0.0661999694334574 no 293 0.0763946785578099 461 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_564 3555-0129 330 µM 1.42718203466835 0.0665527745348728 no 294 0.0767637157287806 355 563260
SGTC_1853 st056710 91.2 µM 1.41700998607727 0.0679657047255096 no 295 0.0782400039331835 472 269167
SGTC_2126 5251174 33.877 µM 1.41192450048991 0.0686807249850543 no 296 0.0789860964069478 573 790722
SGTC_1815 st051655 58.2 µM 1.40939617760438 0.0690383598502513 no 297 0.0793590268435515 427 5984156
SGTC_2840 9008771 71.43 µM 1.40572923128162 0.069559602748351 no 298 0.0799022717065992 409 2992978
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.40426793336292 0.0697681632575805 no 299 0.0801195396492242 514 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2608 thymoquinone 42.66 µM 1.39955725491993 0.0704437618542647 no 300 0.0808229708796522 421 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1624 st003710 6.25 µM 1.39743257255182 0.0707501216700159 no 301 0.0811417649130923 547 24207033
SGTC_1308 1187-1617 41.4 µM 1.39615707991598 0.0709345272313472 no 302 0.0813335991024812 524 2882570
SGTC_2038 4100038 30.985 µM 1.39009061283565 0.0718166500532131 no 303 0.082250681724697 490 3596803
SGTC_3124 9127567 49.47 µM 1.38875898246012 0.0720114033186834 no 304 0.0824530259268062 451 17592030
SGTC_3010 9080089 71.4286 µM 1.38795109911901 0.0721297548612992 no 305 0.0825759681236624 471 17027233
SGTC_2886 9058944 51.95 µM 1.38543842339961 0.0724988044775732 no 306 0.0829592244470983 291 4949929
SGTC_1207 2099-0101 141 µM 1.37868471885592 0.0734979245324251 no 307 0.0839959915108264 530 5837381
SGTC_1950 st077106 7.18 µM 1.37294999764462 0.0743545368843709 no 308 0.0848839459240685 502 13831864
SGTC_3156 9099931 49.47 µM 1.37248500098412 0.0744243275534921 no 309 0.084956252496652 497 18111053
SGTC_1176 0848-0131 83.3 µM 1.37243374340338 0.0744320237882002 no 310 0.0849642258298766 552 6769040
SGTC_2473 5854593 8.94 µM 1.37213407126429 0.0744770311885389 no 311 0.0850108523236867 458 2872951
SGTC_2164 5685496 200 µM 1.36540618400675 0.0754929622690299 no 312 0.0860627106647451 514 759046
SGTC_676 falcarinol 140 µM 1.36410382709925 0.0756908363781987 no 313 0.0862674452272062 519 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_67 0335-0847 266 µM 1.36409096394569 0.0756927927150267 no 314 0.0862694691700775 659 4552207 YOR254C SEC63
SGTC_2570 licareol 100 µM 1.35389785627763 0.0772551876954344 no 315 0.087884483779443 503 443158
SGTC_60 0986-0278 202 µM 1.34748282776824 0.0782509682701409 no 316 0.088912390189962 384 3110598
SGTC_2592 piperlongumine 83.33 µM 1.3452476089204 0.0786002100738259 no 317 0.0892726431336719 465 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_515 4092-1064 102 µM 1.34330049002959 0.0789053993900429 no 318 0.0895873467518841 582 717353
SGTC_418 lividomycin a 100 µM 1.34224337059976 0.0790714666897331 no 319 0.0897585491112039 539 72394 An antibiotic.
SGTC_3126 9127922 49.47 µM 1.33711096920854 0.0798815010995585 no 320 0.0905932085762469 533 45595682
SGTC_1368 1852-0141 284 µM 1.33435946166537 0.0803183408964609 no 321 0.0910430394469612 508 2838987
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.33072004052354 0.0808989191932049 no 322 0.0916405731695953 560 688667
SGTC_995 3931-2021 34.6 µM 1.32920977106176 0.0811407727884376 no 323 0.0918893861620398 503 730143
SGTC_1113 artemisinin 1.17947 µM 1.32893773423762 0.0811843945226787 no 324 0.0919342566542295 539 2240 An anti-malaria and mitochondrial poison.
SGTC_976 1348-1067 47.6 µM 1.32854407814098 0.0812475495150426 no 325 0.0919992160861551 595 5310671 YGL099W LSG1
SGTC_828 2074-0507 139 µM 1.32586081305837 0.0816790185671528 no 326 0.0924429025612374 557 X828
SGTC_1914 st062367 72.6 µM 1.32582973283938 0.0816840263672427 no 327 0.0924480510343837 504 978205
SGTC_542 3381-0244 89.3 µM 1.32568980169459 0.0817065756391182 no 328 0.0924712334134227 601 1112843
SGTC_531 3788-1495 174 µM 1.32510692282933 0.0818005544218511 no 329 0.0925678451716538 514 2896655
SGTC_2874 9043904 71.43 µM 1.3247719963334 0.0818545921691915 no 330 0.0926233927697842 422 4463428
SGTC_1271 0832-2808 169 µM 1.32371563729363 0.0820252036103418 no 331 0.0927987515529927 545 3663794
SGTC_1202 1988-0068 29.6 µM 1.32273985546105 0.0821830390377176 no 332 0.0929609522909636 546 2850480
SGTC_2447 5741742 33.78 µM 1.3149327882658 0.0834541005323635 no 333 0.0942662460218685 552 1776504
SGTC_3265 9137266 49.47 µM 1.31468979607649 0.0834938976307581 no 334 0.0943070886523913 461 17224265
SGTC_2009 4012297 12.05 µM 1.31423482523556 0.0835684508011307 no 335 0.094383596186498 516 45595307
SGTC_2160 5660466 132.927 µM 1.30737586607503 0.0846984537987815 no 336 0.0955425448294939 528 2859134
SGTC_2518 prenyletin 46.28 µM 1.30735524475469 0.0847018683219077 no 337 0.0955460449053028 441 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_778 3456-2434 196 µM 1.30722457021422 0.0847235080966625 no 338 0.0955682266097303 634 5539063
SGTC_396 dithiazanine 1.25 µM 1.30620248437327 0.0848929091201313 no 339 0.0957418540987743 507 10578 An antihelmenthic.
SGTC_183 3914-0051 30.55 µM 1.30311640664553 0.0854059380146796 no 340 0.0962675115834746 538 1596232
SGTC_1247 0448-0043 5.84 µM 1.30289447342523 0.0854429214581756 no 341 0.0963053954905702 579 3089013 YGL099W LSG1
SGTC_3107 9121808 49.47 µM 1.30114410658005 0.0857350269291224 no 342 0.0966045664290231 433 662681
SGTC_781 4335-2806 94.4 µM 1.3010226348995 0.0857553261242832 no 343 0.0966253535508536 623 845254
SGTC_330 1488-0319 80.1 µM 1.29928693326865 0.0860457732276614 no 344 0.0969227384721522 547 6846614
SGTC_393 acivicin 6.25 µM 1.2959036947808 0.0866140287210179 no 345 0.0975043330804256 504 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1469 k284-2957 126 µM 1.29570189023131 0.0866480126548284 no 346 0.0975391049488622 525 23884841
SGTC_834 0312-0008 75.7 µM 1.29463672679809 0.0868275515677292 no 347 0.0977227882811451 580 6385573 YIL048W NEO1
SGTC_2536 dehydroabietamide 32.04 µM 1.2925763843773 0.0871756217326663 no 348 0.0980788058560106 587 3983547
SGTC_2700 st077718 96.8 µM 1.29086204731201 0.0874660317287702 no 349 0.0983757588973668 511 904970
SGTC_185 k048-0037 25.491 µM 1.28736320781583 0.0880609774308836 no 350 0.0989838609642695 577 6827589
SGTC_1414 3917-0015 5.4 µM 1.2846661928125 0.0885216355698485 no 351 0.0994544784568193 508 6618702
SGTC_979 1426-2828 121 µM 1.27790716948556 0.0896839802455043 no 352 0.100641079922431 590 747872
SGTC_1383 3049-0032 20.7 µM 1.27776671160426 0.0897082544725332 no 353 0.100665847501705 572 712864
SGTC_3246 9135460 32.98 µM 1.27772158528391 0.0897160543349717 no 354 0.100673805775278 469 41446951
SGTC_3343 9148379 18.9835 µM 1.27674505420272 0.0898849664552909 no 355 0.100846134801796 565 1955036
SGTC_1074 carmofur 3.8 µM 1.26998532564351 0.0910606929217377 no 356 0.102044928658401 620 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3137 9097352 49.47 µM 1.26904941316088 0.0912243719986118 no 357 0.102211720451079 616 44120435
SGTC_1651 st011928 86.1 µM 1.26834968919247 0.0913468871833826 no 358 0.102336549866679 570 720198
SGTC_425 3825-7017 13.1 µM 1.26752889136714 0.0914907566922674 no 359 0.102483119889669 619 3397440
SGTC_1627 st003713 25.6 µM 1.26699899901039 0.0915837254306973 no 360 0.10257782390558 654 16195070 YER133W GLC7
SGTC_679 0422-0091 41.4 µM 1.26092448763568 0.0926544939632104 no 361 0.103668027317365 598 627384 YHR062C RPP1
SGTC_2805 7950783 58.44 µM 1.25975799151493 0.092861170551398 no 362 0.103878339128832 637 1178958 YDL195W SEC31
SGTC_1233 0325-0408 14.2 µM 1.25854533140811 0.09307638751121 no 363 0.104097301897732 571 12874
SGTC_2997 9067075 71.4286 µM 1.25462574841113 0.0937745372317724 no 364 0.10480732590086 618 27209819
SGTC_2128 5255449 168.493 µM 1.25277609743702 0.0941053334270201 no 365 0.105143601407379 611 736008
SGTC_2532 xanthone 78.9 µM 1.25238693543931 0.094175041620431 no 366 0.105214452256173 530 7020 An insecticide.
SGTC_2158 5657123 3.6195 µM 1.25177451463462 0.0942848179175918 no 367 0.10532601956108 568 2858827
SGTC_1315 1237-0019 3.69 µM 1.25132094289219 0.0943661813679523 no 368 0.105408703805353 598 825140
SGTC_2043 5101342 149 µM 1.2476802133238 0.0950211460817234 no 369 0.106074095113462 583 678451
SGTC_40 0327-0103 19.753 µM 1.24688633531219 0.0951644078172725 no 370 0.106219588918678 574 409036
SGTC_1655 st012546 55.1 µM 1.24579630431516 0.0953613718136918 no 371 0.106419593358199 535 720985 YLR208W SEC13
SGTC_49 0717-0965 32.132 µM 1.2431101486353 0.0958480295117828 no 372 0.106913623262535 596 5889349 YGL099W LSG1
SGTC_2995 9067767 71.4286 µM 1.23832346054962 0.0967197698405746 no 373 0.107798074087629 525 11673567
SGTC_939 1165-0479 45.3 µM 1.23522368252057 0.0972873920103566 no 374 0.108373633828447 597 1377347
SGTC_906 1165-0455 526 µM 1.23333793723214 0.0976338976781656 no 375 0.108724854733898 576 3252859
SGTC_682 0kpi-0099 17 µM 1.23294483058394 0.0977062448652952 no 376 0.108798174012091 628 1714895 YML126C ERG13
SGTC_326 k292-0812 17.5 µM 1.22778337478315 0.0986598055871372 no 377 0.109764149129162 575 3579357
SGTC_2909 7941780 10.49 µM 1.2275164610149 0.0987093015486998 no 378 0.109814269370675 611 1243215
SGTC_1797 st048695 56.8 µM 1.22735982834415 0.0987383556618488 no 379 0.109843689015868 606 592262 YIL048W NEO1
SGTC_130 0136-0219 337.655 µM 1.22440736294432 0.0992871858392663 no 380 0.110399296556835 626 234244
SGTC_2212 7123476 200 µM 1.22356181972602 0.099444772916874 no 381 0.110558785025754 505 1085715
SGTC_2808 7946468 45.46 µM 1.21722625367941 0.100631376607538 no 382 0.111759071965752 657 2970879
SGTC_1498 4478-3555 97.6 µM 1.21266789192501 0.101491489423873 no 383 0.112628410187644 549 3437919
SGTC_281 1672-3440 14.9 µM 1.21243808384461 0.101534993024535 no 384 0.112672365066233 661 6833000
SGTC_1034 k072-0165 12.7 µM 1.21237277596934 0.101547358547632 no 385 0.112684858592782 642 5835461
SGTC_2298 7976326 193.81 µM 1.21217554145875 0.101584709979984 no 386 0.112722595952565 538 2235818
SGTC_64 000l-0018 272.079 µM 1.20951903816605 0.102088762426412 no 387 0.113231750708557 716 6811119
SGTC_2139 5578692 56.4705 µM 1.20648938575421 0.102665835441849 no 388 0.11381442463716 551 650991 YMR113W FOL3
SGTC_1891 st059073 26.2 µM 1.20608911944575 0.102742253122718 no 389 0.113891564848009 662 688754
SGTC_2859 9028643 45.46 µM 1.20297234057791 0.10333871400215 no 390 0.114493512113652 571 17151580
SGTC_256 clotrimazole 625 nM 1.20104060709865 0.103709651236203 no 391 0.114867724984521 612 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3293 9120939 62.045 µM 1.19951019558654 0.104004210523291 no 392 0.11516481136226 602 934087
SGTC_265 mycophenolic acid 32.932 µM 1.19821951939001 0.104253098966585 no 393 0.115415784162394 677 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1114 scopoletin 1.73284 µM 1.1976756479492 0.104358105978131 no 394 0.115521656622425 609 5280460 A coumarin with genotoxic properties.
SGTC_3202 9113761 49.47 µM 1.19586724878543 0.10470781052248 no 395 0.115874183852917 692 4798415
SGTC_467 ro 31-8220 72.8 µM 1.19253208012321 0.105354983112392 no 396 0.116526339838789 654 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_552 k242-0005 476 µM 1.1847832752011 0.106869759798116 no 397 0.118051573456633 620 4088318
SGTC_918 glabranin 770.725 nM 1.18455259190762 0.106915094586058 no 398 0.118097195369991 647 124049 Also referred to as licorice root.
SGTC_631 k072-0230 41.5 µM 1.1825551387479 0.107308222200921 no 399 0.118492750387103 687 5773147
SGTC_1931 st074438 57.1 µM 1.18013785898247 0.107785370114853 no 400 0.11897269461773 610 2787313
SGTC_2395 5646831 180.19 µM 1.17250348329085 0.109302353638531 no 401 0.120497487222683 648 6808628
SGTC_972 1319-0219 195 µM 1.16778052791529 0.110248471198324 no 402 0.121447652242764 645 23903702
SGTC_1403 3909-7815 62.9 µM 1.16637684681657 0.110530790013949 no 403 0.121731057700854 596 6615483
SGTC_2655 perillic acid 100 µM 1.16267642290371 0.111277529800593 no 404 0.122480405473304 593 5702197 An apoptosis inducer.
SGTC_722 3534-0461 190 µM 1.15877130618635 0.112069485723619 no 405 0.123274708229526 649 658262
SGTC_983 1491-0821 12.2 µM 1.15712422252775 0.112404718865597 no 406 0.123610805803407 643 46495113
SGTC_1527 coumarin 137 µM 1.15689519834009 0.112451389142407 no 407 0.123657590368997 590 323 A hepatotoxic, DNA x-linker.
SGTC_2295 7971645 200 µM 1.15340080475801 0.113165190051834 no 408 0.124372955663516 657 2978226 YKL099C UTP11
SGTC_1790 st045711 43.5 µM 1.15166108491778 0.113521766118258 no 409 0.124730184682793 648 585119
SGTC_2223 6903751 107.57 µM 1.1497435428693 0.113915716285754 no 410 0.125124757249997 616 5598863
SGTC_2205 7238770 200 µM 1.1494350908515 0.113979177171346 no 411 0.1251883087097 640 279867
SGTC_1399 3562-5772 25 µM 1.14751777404912 0.114374210648951 no 412 0.125583845753707 571 23847490
SGTC_1691 st019933 84.6 µM 1.14260496358941 0.115390865413392 no 413 0.126601321888837 641 6176082
SGTC_2412 st077135 33.4 µM 1.14242174338989 0.115428904749305 no 414 0.126639378765361 672 13258915
SGTC_309 k408-0051 1.48 µM 1.14072628488413 0.115781330865106 no 415 0.126991922391376 742 3640463
SGTC_169 k015-0017 16.025 µM 1.13626222866745 0.116712903831935 no 416 0.127923416833728 613 1840002
SGTC_1142 3253-1408 9.78 µM 1.1361153111508 0.116743653099438 no 417 0.127954153931595 648 256655
SGTC_695 3505-6186 243 µM 1.13109561708309 0.117797707983167 no 418 0.12900742442722 702 1819379
SGTC_1762 st045503 25.4615 µM 1.12829501375464 0.118388707879492 no 419 0.1295976742948 675 4645554
SGTC_3127 9126946 49.47 µM 1.12726415098898 0.11860677349898 no 420 0.129815407275485 599 27243249
SGTC_3347 9188721 44.724 µM 1.12443649801873 0.119206383258441 no 421 0.13041394789212 650 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3339 9145883 14.936 µM 1.12104095944023 0.119929237713559 no 422 0.131135213986119 654 2030670
SGTC_1484 3473-2379 286 µM 1.11777199679464 0.120628060311334 no 423 0.131832192182131 793 671917
SGTC_2379 9035213 200 µM 1.11554186938191 0.121106447925548 no 424 0.132309143374432 754 646551
SGTC_1588 farnesol 29.9 µM 1.11172721000748 0.121927826319853 no 425 0.133127728441855 710 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1426 4048-4480 71.7 µM 1.11133498001431 0.122012503218923 no 426 0.133212093993779 707 14224343
SGTC_2656 pseudo-anisatin 100 µM 1.11128724699427 0.122022810919932 no 427 0.133222363497234 692 6708809 A neurotoxin.
SGTC_962 1254-0300 21.5 µM 1.11071445531803 0.122146550048558 no 428 0.133345639049026 688 7340576
SGTC_1285 0929-0069 65.5 µM 1.10958087257757 0.122391695488207 no 429 0.133589838673573 698 1206237
SGTC_635 k038-0028 24.7 µM 1.10955188377015 0.122397969051563 no 430 0.133596087555133 709 4035102
SGTC_730 1436-0052 41.2 µM 1.10808465698325 0.122715791259098 no 431 0.133912628267859 658 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1733 st037357 54.9 µM 1.1054028832321 0.123298196587072 no 432 0.134492527499486 684 1272339 YGL099W LSG1
SGTC_402 epigallocatechin gallate 10 µM 1.10460593712276 0.123471643401016 no 433 0.134665188676373 722 65064 An antioxidant.
SGTC_2397 5161689 200 µM 1.10209141999575 0.124020021267948 no 434 0.135210964568613 721 2259942
SGTC_1850 st056238 17 µM 1.10148583307605 0.124152344811793 no 435 0.135342633474689 748 5393177
SGTC_2797 7859098 81.82 µM 1.1001099700493 0.124453344277992 no 436 0.135642105180741 705 972681
SGTC_94 0334-0113 514.748 µM 1.09905537909638 0.124684403788159 no 437 0.135871955588381 691 6795178
SGTC_3016 9080866 49.47 µM 1.09879961414799 0.124740486703296 no 438 0.135927740280574 732 17066299
SGTC_912 3474-0017 2.18 µM 1.09619094626283 0.125313509912242 no 439 0.136497610449424 723 3360550
SGTC_2225 6654152 15.4 µM 1.09614766572478 0.125323032440805 no 440 0.136507078953777 632 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2941 9056145 11.23 µM 1.09256886156509 0.12611218481186 no 441 0.137291570312924 622 2119517
SGTC_546 peri-Naphthalide 147 µM 1.08984512592122 0.126715105257124 no 442 0.13789068604585 715 223824 A penicillin ester.
SGTC_673 1082-0474 110 µM 1.08812122804159 0.12709773932518 no 443 0.13827079674538 809 3098046
SGTC_2442 5158906 48.48 µM 1.08811725253729 0.127098622651015 no 444 0.13827167414856 734 1893835
SGTC_1999 st074831 12.5 µM 1.08578162833132 0.127618318685537 no 445 0.138787808150416 728 17112523
SGTC_1227 3909-8010 46.6 µM 1.08558407384535 0.127662343885834 no 446 0.1388315245044 707 15982272
SGTC_655 k060-0012 42 µM 1.08474428007378 0.127849610533235 no 447 0.139017465087726 706 5994525
SGTC_325 2810-4341 181 µM 1.0846543510926 0.127869675217068 no 448 0.139037386505541 725 774970
SGTC_1130 3454-2858 15.9 µM 1.08306626692987 0.128224364326011 no 449 0.139389505277858 703 715628 YIL048W NEO1
SGTC_1381 2324-0066 62.1 µM 1.08199691103982 0.128463583154227 no 450 0.13962695025672 681 10885928
SGTC_1451 4152-0210 104 µM 1.08059677163042 0.1287772675666 no 451 0.139938259615291 738 659563
SGTC_1318 1280-3875 124 µM 1.08058017164188 0.128780989779173 no 452 0.139941953311906 745 373245
SGTC_2337 9009472 200 µM 1.08045543471818 0.128808961905727 no 453 0.13996971089353 756 5742383
SGTC_1926 methyl fluorone black 53.6 µM 1.0798512232244 0.128944515362885 no 454 0.140104218419708 646 72721 Reacts with homocysteine.
SGTC_2198 6589944 200 µM 1.07969070969735 0.128980542829269 no 455 0.140139966158504 629 5290268
SGTC_1917 st066507 28.5 µM 1.07809694205254 0.129338644798783 no 456 0.140495248080402 754 3156428
SGTC_3354 9151612 71.43 µM 1.07437130178555 0.130178441174607 no 457 0.141328149770025 767 27261949
SGTC_576 1073-0113 22.7 µM 1.07379507364264 0.130308664888977 no 458 0.141457269199452 913 5439563
SGTC_652 0437-0092 114 µM 1.07098824772614 0.130944277293113 no 459 0.142087356974967 704 3091274
SGTC_1873 rapamycin 2 nM 1.070193348192 0.131124672804583 no 460 0.142266143925561 778 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3085 9117376 49.47 µM 1.06815026179414 0.131589120842061 no 461 0.142726368327584 721 16480349
SGTC_2831 7999036 19.48 µM 1.06648908068581 0.131967587572365 no 462 0.143101306066218 778 2988270
SGTC_96 0929-0093 37.281 µM 1.06502389536592 0.132302023150091 no 463 0.143432558274812 703 6991579
SGTC_2697 mebhydrolin 72.4 µM 1.06275206872122 0.132821732794638 no 464 0.143947200603597 779 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_352 k048-0007 5.11 µM 1.06274013324582 0.132824466895726 no 465 0.1439499076602 795 6811911
SGTC_1642 st009582 77.7 µM 1.06152721297962 0.133102516891005 no 466 0.144225186261074 699 6739311
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.0591662645918 0.133644889177505 no 467 0.144762032955758 723 803109
SGTC_924 2046-0044 21.3 µM 1.05579927902284 0.134421000530086 no 468 0.145529963851391 757 3623589
SGTC_686 1319-0111 510 µM 1.05473376692219 0.134667251097538 no 469 0.145773551921941 779 4562600
SGTC_1164 k060-0068 93.7 µM 1.05465832356356 0.134684698545641 no 470 0.145790809506835 785 5963676
SGTC_264 promethazine 12.5 mM 1.05323927397025 0.135013164822523 no 471 0.146115671373686 880 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_937 3122-0005 46.7 µM 1.04864977166699 0.136079253040063 no 472 0.14716966979362 803 759535
SGTC_901 1112-0062 60.1 µM 1.0450720984395 0.136914291499245 no 473 0.147994824210603 732 1908457
SGTC_2218 6965428 192.983 µM 1.04178541928015 0.137684491469903 no 474 0.148755587820918 755 675684
SGTC_602 3130-1533 38.1 µM 1.03705471559616 0.138798266125717 no 475 0.149855179010951 824 720941
SGTC_2188 6126565 140.678 µM 1.03354870589935 0.139627652980938 no 476 0.150673594809554 718 874518
SGTC_1456 k015-0012 13 µM 1.03254251489979 0.139866300108121 no 477 0.150909020905386 854 2989616
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.03251334146952 0.139873223559078 no 478 0.150915850483337 803 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_54 0159-0055 9 µM 1.03070035208342 0.14030394005334 no 479 0.151340679803584 767 3319099
SGTC_3244 9134489 49.47 µM 1.02825084212442 0.140887305616702 no 480 0.151915924060958 754 16584271
SGTC_1459 k035-0031 35.7 µM 1.02682608186444 0.141227376703496 no 481 0.152251182825802 688 3877128 YMR208W ERG12
SGTC_2439 5492030 7.2 µM 1.02424908782102 0.141843883041896 no 482 0.152858819246822 754 5722370
SGTC_1507 4075-3230 155 µM 1.02251264084342 0.142260327629714 no 483 0.153269166439864 702 659771
SGTC_3159 9100096 49.47 µM 1.02221369615642 0.142332105633188 no 484 0.153339884911441 749 25236875
SGTC_1273 0849-0096 14.1 µM 1.01903015240196 0.143098008999292 no 485 0.154094325982406 769 5286025
SGTC_1877 wortmannin 25 µM 1.01868624546571 0.14318091314741 no 486 0.154175972285331 826 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2008 4012253 172 µM 1.01695600071179 0.143598507881184 no 487 0.154587180505949 789 603940
SGTC_943 3253-1379 105 µM 1.01464639566035 0.144157211095775 no 488 0.155137207442322 774 668464
SGTC_24 0417-1663 219 µM 1.01290690713074 0.144578967065561 no 489 0.155552314443572 764 4329390
SGTC_115 0527-0192 112.043 µM 1.00838122991788 0.145680153253051 no 490 0.156635740175115 880 4233931
SGTC_1560 lithocholic acid 53.1 µM 1.00612989707075 0.146230041531609 no 491 0.157176544369773 725 9903 A bile acid which acts as a detergent.
SGTC_1953 st076800 12.1 µM 1.00388498492873 0.146779747842871 no 492 0.157717027354042 795 297591
SGTC_1230 0170-0365 3.77 µM 1.00272334545249 0.147064739346256 no 493 0.157997181359397 930 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_368 fentichlor 4.58 µM 1.00023343591165 0.147676851996108 no 494 0.15859877586756 712 7329 A pesticide.
SGTC_2591 skatole 100 µM 0.999722273275917 0.147802725643919 no 495 0.158722464999961 781 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2923 7992654 58.14 µM 0.998501421325912 0.148103650688862 no 496 0.159018137800304 780 2985126
SGTC_3036 9090181 49.47 µM 0.9935604714156 0.149325719417375 no 497 0.160218448257812 799 25236586
SGTC_2006 4011487 200 µM 0.989983815592667 0.150214539740894 no 498 0.161091014855505 840 45595294
SGTC_1336 1486-0901 104 µM 0.989730617556025 0.150277594334268 no 499 0.161152902759478 815 5006114
SGTC_230 MPP+ 141.667 µM 0.989060223167422 0.15044462963371 no 500 0.161316838741222 771 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3345 9148410 3.559 µM 0.98844605356818 0.150597764502269 no 501 0.161467121141467 813 4903596
SGTC_1345 1488-0192 31.4 µM 0.987511016447213 0.150831102610024 no 502 0.161696092495272 845 658348
SGTC_369 0957-0393 4.5 µM 0.987071687412048 0.150940820044698 no 503 0.161803748177075 752 6997992
SGTC_1961 st076550 68.7 µM 0.984933405559696 0.151475589940191 no 504 0.162328391613674 749 1579337
SGTC_766 1391-0721 126 µM 0.981302215808558 0.152386608758182 no 505 0.163221865191173 832 1020919 YIL115C NUP159
SGTC_2432 5630864 12.22 µM 0.980663104601273 0.152547329125655 no 506 0.163379451996108 788 5714970
SGTC_3136 9095672 49.47 µM 0.979871709618912 0.15274650083618 no 507 0.163574724601716 725 17217380
SGTC_3103 9120822 49.47 µM 0.979101655018214 0.15294046726959 no 508 0.16376487699255 857 17141819
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.978527467710229 0.153085203594179 no 509 0.163906756499825 878 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2545 solidagenone 89.61 µM 0.975098238092068 0.153951504815153 no 510 0.16475576626087 602 6708572 An anti ulcer agent
SGTC_946 3434-1334 87.4 µM 0.97410898366445 0.154202014650147 no 511 0.165001214704983 809 4047976
SGTC_1269 0831-0796 3.05 µM 0.974012374953336 0.154226493407597 no 512 0.165025197417946 834 927758
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.973609190785274 0.154328680130538 no 513 0.165125310582961 853 165521
SGTC_251 melphalan 456.522 µM 0.973247929445578 0.154420279564999 no 514 0.165215047434419 921 460612 A DNA alkylator.
SGTC_1967 st070177 51.4 µM 0.971713942581521 0.154809629090119 no 515 0.165596439273136 807 5729214
SGTC_456 gingerol 170 µM 0.971027693377858 0.154984019499652 no 516 0.165767244121145 849 442793 A herb.
SGTC_2374 9071832 200 µM 0.969166991441221 0.155457515662965 no 517 0.166230938705545 822 17381698
SGTC_1087 pterostilbene 9.05 µM 0.968691570765713 0.155578649743085 no 518 0.166349549741612 848 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1003 4049-0218 100 µM 0.967951420419975 0.155767359098905 no 519 0.166534315996929 842 295161
SGTC_490 phenamil 164 µM 0.967495111015342 0.155883775306574 no 520 0.166648292054507 733 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_725 1497-0963 19 µM 0.967023726243294 0.156004097842873 no 521 0.166766086457942 873 3549977
SGTC_2096 5468907 200 µM 0.966855575539775 0.156047033679362 no 522 0.16680811865598 843 759785
SGTC_2650 prasterone 100 µM 0.966313761060332 0.156185434318642 no 523 0.166943601112463 774 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1169 aniline yellow 25.8 µM 0.964347516746431 0.156688369217556 no 524 0.167435862768892 812 6051 A DNA damaging agent.
SGTC_415 dibenzyl ketone 100 µM 0.963966860917071 0.156785858117269 no 525 0.167531270303633 846 7593
SGTC_3222 9128301 49.47 µM 0.963204646060042 0.156981187194389 no 526 0.167722417003133 853 4911358
SGTC_1048 3161-0300 24.5 µM 0.962162004442252 0.157248639016798 no 527 0.167984115917193 864 2165101
SGTC_2488 5268135 45.7 µM 0.961834120056363 0.157332807727176 no 528 0.168066467888524 895 1270356 YLR208W SEC13
SGTC_3180 9109287 49.47 µM 0.960666226010211 0.157632849513322 no 529 0.168360009075625 791 18891271
SGTC_1413 3910-0535 34.4 µM 0.960517349133026 0.157671124230408 no 530 0.168397451814861 891 2876951
SGTC_1504 k297-0033 30 µM 0.95868887713548 0.158141703533637 no 531 0.168857751750698 712 4388117
SGTC_1856 st057054 55.7 µM 0.955794871122913 0.158888393033878 no 532 0.169587940031347 892 1266018
SGTC_1893 st059353 36.1 µM 0.951946582431174 0.15988487259664 no 533 0.170562036714069 833 3112488
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.951936320638242 0.159887535248121 no 534 0.170564639006543 871 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1036 k216-0215 33.5 µM 0.951740985223038 0.159938224917155 no 535 0.170614179045723 843 622330
SGTC_2052 5265182 7.135 µM 0.949474249296442 0.160527212946125 no 536 0.171189731392643 865 1239884
SGTC_1186 1319-0216 26 µM 0.948572744818078 0.160761852946696 no 537 0.171418979229364 904 4565136
SGTC_2850 9015429 58.44 µM 0.946465285958952 0.161311247196015 no 538 0.171955660013137 804 6457570
SGTC_470 aa-861 153 µM 0.946455228139589 0.161313872105533 no 539 0.171958223884419 855 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1619 st003326 88.7 µM 0.942144557784429 0.162441443990718 no 540 0.173059317262144 829 2849032
SGTC_1825 st052143 62.6 µM 0.941964915289326 0.162488545390491 no 541 0.17310530140612 837 674173
SGTC_1042 0350-0096 82 µM 0.941719571040946 0.162552887830634 no 542 0.173168116185157 832 3122515
SGTC_1228 0124-0032 52.5 µM 0.940123281890264 0.162971925340026 no 543 0.1735771639047 903 X1228
SGTC_554 4483-2211 187 µM 0.937946661894379 0.163544434523615 no 544 0.174135910803805 839 747107
SGTC_1699 st031318 29.054 µM 0.937874978938946 0.163563311242272 no 545 0.174154331523694 896 5340658
SGTC_3296 9122258 64.045 µM 0.935300151255707 0.164242294678373 no 546 0.174816818693308 864 4730474
SGTC_895 0964-0006 13.7 µM 0.932354936248492 0.165021187248773 no 547 0.175576562728517 870 6738897
SGTC_2246 7293507 91.5585 µM 0.929018752307031 0.165906359628011 no 548 0.176439684085966 917 887656
SGTC_2541 muurolladie-3-one 83.07 µM 0.928516357136691 0.166039922902473 no 549 0.176569893480515 835 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2922 7999257 32.47 µM 0.924741418529601 0.167045723246435 no 550 0.177550214641734 821 2988377
SGTC_2282 7944268 200 µM 0.922792401830567 0.16756655686148 no 551 0.178057700608522 885 2970414
SGTC_2146 5545642 200 µM 0.922552751756984 0.167630670433263 no 552 0.178120163894332 898 825326
SGTC_1547 harmine 94.2 µM 0.922364677551034 0.167680996979618 no 553 0.178169193927096 950 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1167 k781-0610 148 µM 0.921665726427703 0.167868113721193 no 554 0.178351481637172 913 4525169
SGTC_1568 digitonin 820 nM 0.921442920460302 0.167927789521779 no 555 0.178409614525758 933 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2717 st081029 62.2815 µM 0.919557177276222 0.168433409109033 no 556 0.178902106694022 873 5292846
SGTC_2948 9070189 9.45 µM 0.919080719696619 0.168561315244611 no 557 0.179026676530595 808 6473636 YDL196W YDL196W
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.917944697542162 0.168866534869163 no 558 0.179323909655039 938 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1085 doxorubicin 7.67 µM 0.917716275978081 0.168927948655503 no 559 0.179383712184111 955 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3020 9089140 49.47 µM 0.915276428637478 0.16958482484595 no 560 0.180023265121035 897 17217859
SGTC_2958 9077254 16.72 µM 0.915083787325185 0.169636759065195 no 561 0.180073822763777 852 16457351
SGTC_2104 5389443 200 µM 0.914547830252888 0.169781301536175 no 562 0.180214528615272 916 2244536
SGTC_1066 ketoconazole 628 nM 0.914060694658624 0.169912745820006 no 563 0.18034247711473 947 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2162 5663267 200 µM 0.913618005032946 0.170032253773143 no 564 0.180458801090414 947 6456493
SGTC_671 0560-0003 407 µM 0.913232236609381 0.170136439267426 no 565 0.180560206454556 867 3238678
SGTC_3303 9125618 40.5795 µM 0.913159214536214 0.170156165134878 no 566 0.180579405489564 939 22695467
SGTC_137 0438-0332 85.389 µM 0.913024595205467 0.170192534460596 no 567 0.180614803091518 969 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1756 st041558 35.5 µM 0.911085784720376 0.170716884045307 no 568 0.181125087899913 976 3955792
SGTC_2767 sibutramine 71.45 µM 0.910301093065933 0.170929396834753 no 569 0.181331871127808 920 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1798 st045719 60.953 µM 0.909598255278844 0.171119885314906 no 570 0.181517209534575 855 3980186
SGTC_729 4092-0585 94.1 µM 0.908823463442804 0.171330032595563 no 571 0.181721659578915 843 2169061
SGTC_1124 fisetin 1.16336 µM 0.908263599917906 0.171481987369002 no 572 0.181869484534098 855 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_316 k060-0003 58.6 µM 0.907998956003842 0.171553845389442 no 573 0.181939386617842 885 6152314
SGTC_3352 9151559 45.5865 µM 0.907187946331159 0.171774176382225 no 574 0.182153708392704 869 17159339
SGTC_1330 1469-0054 61.8 µM 0.903859830799649 0.172680233495328 no 575 0.183034865680861 960 7102664
SGTC_351 caspofungin 25 nM 0.903514324248084 0.172774469591307 no 576 0.183126494689014 1003 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2807 7945238 51.95 µM 0.903284699208015 0.172837117406936 no 577 0.183187407520217 893 17148797
SGTC_3193 9111931 49.47 µM 0.901752817278557 0.17325542589718 no 578 0.183594094448701 902 17087244
SGTC_2601 securinine 100 µM 0.900344047865369 0.173640684787135 no 579 0.183968593458171 853 442872 A GABA receptor antagonist.
SGTC_102 gallobenzophenone 83.616 µM 0.900321882206748 0.173646750824854 no 580 0.18397448964549 912 70837
SGTC_318 1488-0629 67.2 µM 0.898672719015916 0.174098452648821 no 581 0.184413506159382 860 3662576
SGTC_80 0159-0065 512.242 µM 0.898610390100461 0.174115539023415 no 582 0.184430111238103 849 1548079
SGTC_77 0828-0286 12.516 µM 0.898352798782434 0.17418616445188 no 583 0.184498746139278 936 745345
SGTC_1331 1472-0049 76.2 µM 0.897689346560858 0.174368151133172 no 584 0.184675595337373 858 24051409
SGTC_1501 4491-0275 38.4 µM 0.893643715409024 0.175480491035429 no 585 0.185756274432682 944 5104718
SGTC_284 0988-0104 32.6 µM 0.893292111457597 0.175577375966101 no 586 0.18585038067804 945 4666532
SGTC_1781 st038725 66.3 µM 0.890012886181017 0.176482602614495 no 587 0.186729483408613 960 4270275 YIL048W NEO1
SGTC_2505 galangin 7.89 µM 0.888231219812655 0.176975665173437 no 588 0.187208194274025 849 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1001 4048-4355 44.4 µM 0.886480253135376 0.177461079040696 no 589 0.187679395219817 902 21824233
SGTC_1259 0671-0132 43 µM 0.886456737388635 0.177467603936493 no 590 0.187685728501538 881 X1259
SGTC_3033 9090887 49.47 µM 0.88623025134098 0.177530454595411 no 591 0.187746732683258 946 19325384
SGTC_247 mechlorethamine 29.705 µM 0.885660759204379 0.177688552692323 no 592 0.187900179911808 886 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2496 diffractaic acid 79.83 µM 0.884056715138606 0.178134332563751 no 593 0.188332798816025 946 94870 An apoptosis inducer which activates caspases.
SGTC_795 0685-0265 78 µM 0.881509535879997 0.178843666314386 no 594 0.189021047503234 962 302754
SGTC_1128 3448-9350 235 µM 0.879385227645751 0.179436597421341 no 595 0.189596219499513 825 619386
SGTC_48 0382-0018 55 µM 0.878895499936765 0.179573463970499 no 596 0.189728969427228 921 762596
SGTC_2586 curcumin 80 µM 0.878736902470613 0.179617802025026 no 597 0.18977197251155 996 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1742 st038235 28.8875 µM 0.87855374019882 0.179669016060969 no 598 0.189821643705037 886 564103 YBR002C RER2
SGTC_2087 5276107 200 µM 0.878531265364721 0.179675300885352 no 599 0.189827739134372 932 144405
SGTC_2094 5332512 191.667 µM 0.878170817866954 0.179776114682972 no 600 0.189925513017555 983 755774
SGTC_892 0929-0076 29 µM 0.877691668046647 0.179910183415041 no 601 0.190055533651003 958 5751038
SGTC_1492 4158-0558 28.5 µM 0.877551826075822 0.179949323795305 no 602 0.190093491052071 930 3967268
SGTC_3084 9116877 49.47 µM 0.875887441492271 0.180415579021299 no 603 0.190545613703869 882 27241325
SGTC_2525 harmine 47.85 µM 0.875665912830591 0.180477694435129 no 604 0.190605840721615 899 5280953 A monoamine oxidase inhibitor
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.875156623030919 0.180620547347855 no 605 0.190744345693881 919 756377
SGTC_1932 st074806 40.9 µM 0.873875167945877 0.180980301821554 no 606 0.191093119614866 1028 17251235
SGTC_410 α-linolenic acid 100 µM 0.871072937083522 0.181768560604244 no 607 0.191857164867038 970 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3095 9117207 49.47 µM 0.86971664088352 0.182150852655699 no 608 0.192227637947619 916 17015229
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.868997939097142 0.182353632905044 no 609 0.192424129005391 1003 688788
SGTC_1289 0976-0073 69.1 µM 0.868625930843298 0.182458649656104 no 610 0.192525883237634 970 3391136
SGTC_1129 3453-1384 223 µM 0.867942989288644 0.182651540210995 no 611 0.192712771665172 967 1084452
SGTC_1938 st074717 56.4 µM 0.865518430331487 0.183337362480642 no 612 0.193377152318093 885 17250979
SGTC_2653 dihydrofissinolide 100 µM 0.864368920747849 0.183663078568662 no 613 0.193692630130203 971 6857746
SGTC_2059 5238311 157 µM 0.863557487894152 0.183893216814955 no 614 0.19391551311251 904 703021
SGTC_222 nsc-310342 10.666 µM 0.861499624595703 0.184477671968376 no 615 0.194481463916777 922 432556
SGTC_3205 9113483 49.47 µM 0.860352094026691 0.184804084119911 no 616 0.194797492406294 950 17018033
SGTC_2617 dihydrotanshinone i 20.83 µM 0.859594812371887 0.185019687457601 no 617 0.195006217812419 981 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2854 9024559 71.43 µM 0.857882182781211 0.185507861038659 no 618 0.195478761768692 937 3163529
SGTC_458 nppb 133 µM 0.853948226923566 0.186632232342125 no 619 0.196566838177428 948 4549 A chloride channel blocker.
SGTC_745 0469-0705 296 µM 0.852787390547253 0.186964817731054 no 620 0.196888608877855 1053 3486736
SGTC_1751 st044839 27.194 µM 0.849991343641781 0.187767403163685 no 621 0.197664949468299 983 5291326
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.84968332720533 0.187855947032459 no 622 0.197750585220685 1009 5282309
SGTC_475 α-linolenic acid 10 µM 0.849344456990637 0.187953390057132 no 623 0.197844824938502 1047 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2718 lomofungin 53.02 µM 0.849125474194112 0.188016375733829 no 624 0.197905738426311 945 5351222 A RNA synthesis inhibitor.
SGTC_1557 sumaresinolic acid 42.3 µM 0.848633892620655 0.188157816015575 no 625 0.198042520779501 919 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1053 3366-3204 134 µM 0.847745695322031 0.188413538984345 no 626 0.198289805996645 978 3632071 YPR165W RHO1
SGTC_2147 5545932 89.7195 µM 0.845113305438011 0.189172694802953 no 627 0.199023790084031 961 797404
SGTC_1026 k007-1105 30.6 µM 0.845018117013927 0.189200181464613 no 628 0.199050361917887 983 7066794
SGTC_147 4466-0538 29.23 µM 0.843688252642451 0.18958445095854 no 629 0.199421816846824 1097 6742687 YHR072W ERG7
SGTC_1119 parthenolide 318.541 nM 0.843578106162956 0.189616299730307 no 630 0.199452601432747 1029 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2354 9060492 162 µM 0.84305449717137 0.189767745885731 no 631 0.199598982822999 1026 6471895
SGTC_217 ketoconazole 989 nM 0.842497485865107 0.189928934798536 no 632 0.199754773192035 965 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2827 7993847 71.43 µM 0.839527157260706 0.190789914123597 no 633 0.200586778119779 904 2985692
SGTC_820 1582-0060 59.9 µM 0.838128951868916 0.191196025564493 no 634 0.200979142135487 965 3848840
SGTC_877 0771-0151 33.1 µM 0.838087840374519 0.191207974491833 no 635 0.200990685795578 996 6166523
SGTC_2221 6807166 181.081 µM 0.838086478777723 0.191208370243518 no 636 0.200991068123941 949 674925
SGTC_3029 9088683 49.47 µM 0.837742819199495 0.191308271859837 no 637 0.201087579660889 1014 25236615
SGTC_3236 9132701 49.47 µM 0.837573385556778 0.191357537882428 no 638 0.201135172736484 966 24282524
SGTC_1009 4106-0057 9.87 µM 0.836820904556392 0.191576429836258 no 639 0.20134662254906 1041 2928005
SGTC_2487 5918373 44.05 µM 0.833624228880434 0.192508031176114 no 640 0.202246383994533 1048 2876279
SGTC_2513 baicalein 25.65 µM 0.832271849395384 0.192902984878237 no 641 0.202627758225644 997 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3062 9077494 49.47 µM 0.832201937744625 0.192923415569621 no 642 0.202647485154633 962 16459633
SGTC_1457 k015-0032 57.3 µM 0.832083736363764 0.192957961257841 no 643 0.202680840578816 972 4302660
SGTC_3009 9080819 71.4286 µM 0.831766462209811 0.1930507068897 no 644 0.202770388867592 998 17027216
SGTC_1394 3474-0001 65.7 µM 0.830916358808836 0.193299343392084 no 645 0.203010440774172 888 5017666 YIL048W NEO1
SGTC_1068 loratadine 26.9 µM 0.830154825588185 0.193522240929702 no 646 0.203225626300893 959 3957 A H1 histamine antagonist.
SGTC_2924 9010168 62.78 µM 0.827796269520185 0.19421357434776 no 647 0.203892943864688 1001 2993929
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.82713019496738 0.194409084313669 no 648 0.20408163573447 977 688662
SGTC_607 4491-0986 66.8 µM 0.823810475406929 0.19538529265446 no 649 0.205023627254044 1027 698981 YDR232W HEM1
SGTC_449 xestospongin c 11.1929 µM 0.822407979522873 0.195798608676787 no 650 0.205422369713262 1009 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_250 brefeldin a 552.239 µM 0.821790914381755 0.195980625955145 no 651 0.205597952790737 907 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1226 3909-7979 35.4 µM 0.819223744876673 0.196738971717107 no 652 0.20632938493166 1037 6615510
SGTC_2556 citropten 84.59 µM 0.819184540850819 0.196750566406036 no 653 0.206340566795824 1058 2775 A potential DNA crosslinker.
SGTC_1658 st012944 20 µM 0.817578553380684 0.197225896867436 no 654 0.206798938916848 971 24207260
SGTC_3083 9117465 49.47 µM 0.8140382732578 0.19827617846745 no 655 0.207811512774618 1060 16420915
SGTC_936 3005-4620 401 µM 0.813786028675951 0.198351139529034 no 656 0.207883770131767 1049 777207
SGTC_2092 5303694 80.6725 µM 0.81359803632064 0.198407017485453 no 657 0.207937631603017 991 1963699
SGTC_967 1306-0166 352 µM 0.812588250479425 0.198707323940478 no 658 0.208227085134589 1017 4437607
SGTC_610 4215-0184 155 µM 0.812519350760012 0.198727824437765 no 659 0.208246843791757 1024 5605015
SGTC_1057 3448-5381 134 µM 0.812271111962602 0.198801696252708 no 660 0.20831804142918 1046 5497911
SGTC_1309 pyrazolanthrone 13.4 µM 0.812164061250069 0.198833557905847 no 661 0.208348749190481 1066 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_585 0kpi-0023 191 µM 0.811034721256208 0.199169872442151 no 662 0.208672865790467 996 64601
SGTC_1306 1185-0270 9.02 µM 0.80991642007441 0.199503237071412 no 663 0.208994106955635 1055 1548076
SGTC_617 3770-0098 35 µM 0.808701526306044 0.199865776229042 no 664 0.209343425016739 984 5962639
SGTC_634 1611-4317 11.2 µM 0.807298670800139 0.20028489801593 no 665 0.20974721481617 1078 2843522
SGTC_1219 1469-0211 33.1 µM 0.80426726625126 0.201192372186436 no 666 0.210621319002528 1029 6822282
SGTC_3111 9122088 49.47 µM 0.801397522594182 0.202053719623389 no 667 0.211450774455507 944 16876704
SGTC_708 3448-5400 146 µM 0.798889691734244 0.202808243643361 no 668 0.212177188336018 1059 3462195
SGTC_235 0330-0087 5 mM 0.798267382755915 0.202995736351808 no 669 0.212357670929839 1086 46494818 YHR062C RPP1
SGTC_1882 5615643 20 µM 0.795168422689264 0.203930948359626 no 670 0.213257768783953 1016 2253075
SGTC_1692 fluoroquinolonic acid 71 µM 0.794716844356633 0.20406744081628 no 671 0.213389115881709 1024 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1835 st008666 49.2 µM 0.793605521804427 0.204403576891755 no 672 0.213712558438067 948 690455
SGTC_2132 5317594 122.667 µM 0.793042821415489 0.204573899627584 no 673 0.213876437242769 993 794577
SGTC_465 cgp-37157 41 µM 0.792516097628651 0.204733409169922 no 674 0.214029904634735 963 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2769 toremifene 3.73 µM 0.791048558588965 0.205178218990008 no 675 0.214457827928766 1023 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_46 0329-0187a 2.197 µM 0.791017165083712 0.20518774060366 no 676 0.214466987469186 1082 46494817
SGTC_2833 9001315 45.46 µM 0.790578837466653 0.205320712283347 no 677 0.214594900084678 1016 2989378
SGTC_2914 7968218 45.32 µM 0.790192360383097 0.205437996964572 no 678 0.214707718472797 980 2977111
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.790037037121101 0.205485144313783 no 679 0.214753069342513 1092 94937 An inhibitor of serotonin biosynthesis.
SGTC_1667 st014849 34.6 µM 0.789552665701756 0.20563221330826 no 680 0.214894530548551 1076 5348460
SGTC_1466 k213-0079 57.5 µM 0.789279983826268 0.205715034793011 no 681 0.21497419139657 1053 3657981
SGTC_302 1094-0063 18.9 µM 0.785564657661082 0.206845459507506 no 682 0.216061288313083 1007 5440289
SGTC_2888 9058547 12.99 µM 0.784575978670095 0.207146893144427 no 683 0.216351109300753 959 16476514
SGTC_1261 0712-0010 12.7 µM 0.784231529010677 0.207251971765422 no 684 0.216452133975724 1082 2840123
SGTC_3072 9116419 49.47 µM 0.784036651775757 0.207311435431065 no 685 0.216509302194383 1042 17170162
SGTC_1263 0774-1208 64.8 µM 0.779354740438902 0.208743075876288 no 686 0.217885388504276 1103 906585
SGTC_3199 9111318 49.47 µM 0.779228227655834 0.208781841780156 no 687 0.217922642425721 1013 8548020
SGTC_3325 9138760 55.175 µM 0.779162593802962 0.208801954902349 no 688 0.217941970918854 1049 43844959
SGTC_705 1124-0212 310 µM 0.778905606374451 0.208880718229575 no 689 0.218017660579555 1066 9554485
SGTC_2803 7707263 71.43 µM 0.777693115582022 0.209252567038266 no 690 0.218374975857628 1026 2199229
SGTC_202 3594-0513 34.79 µM 0.777062790850431 0.209446029971461 no 691 0.218560862744333 1058 708429
SGTC_291 SEC14.278 35.5 µM 0.77378412324776 0.210454033736644 no 692 0.21952923146012 1100 1068044
SGTC_2348 9022543 33.42 µM 0.773763543668577 0.210460369766152 no 693 0.219535317501048 1058 3162678 YDL140C RPO21
SGTC_1591 genipin 88.4 µM 0.772015693672062 0.21099890533139 no 694 0.220052566288499 1020 442424 A DNA cross-linking agent.
SGTC_2369 9071472 200 µM 0.771301479672912 0.21121919634377 no 695 0.22026412776116 1078 17296037
SGTC_1011 4112-3381 17.4 µM 0.770840060737029 0.211361587280575 no 696 0.220400869329486 1080 2877139
SGTC_889 0919-1524 82.7 µM 0.770535058221665 0.211455739967075 no 697 0.220491283574423 1031 3905452
SGTC_1920 st075728 45.7 µM 0.769732768358931 0.211703519907537 no 698 0.220729213999924 1053 3400306
SGTC_1240 0356-0016 42.1 µM 0.769227028415976 0.211859800379334 no 699 0.220879273877139 1046 4305613
SGTC_1137 ixabepilone 100 µM 0.768268608876112 0.21215615004207 no 700 0.22116381007023 1069 154225 A novel microtubule stabilizer.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.767956504375435 0.212252707104023 no 701 0.221256513093461 1103 115019
SGTC_3190 9110366 49.47 µM 0.767696705170577 0.212333101846243 no 702 0.221333697053334 1013 17123768
SGTC_1570 verbenone 133 µM 0.767009501531357 0.21254584246117 no 703 0.221537933164547 1090 29025 A natural terpanoid with antifungal properties.
SGTC_511 blebbistatin 171 µM 0.766132581121382 0.21281749524039 no 704 0.221798709244674 1089 3476986 A myosin inhibitor.
SGTC_135 0933-0004 26.348 µM 0.765824895606392 0.212912858199692 no 705 0.221890249420637 1020 21230617 YGL099W LSG1
SGTC_3057 9095946 49.47 µM 0.764913856192396 0.213195368726824 no 706 0.222161421194657 1137 24540043
SGTC_2309 7664088 163.95 µM 0.763706406901502 0.213570131726048 no 707 0.222521110940391 1109 704922
SGTC_2899 9053889 58.44 µM 0.762929055898847 0.21381160561657 no 708 0.222752853353377 1069 6470052
SGTC_3301 9125354 19.7965 µM 0.76233674577477 0.213995705667554 no 709 0.222929524017709 1043 41905162
SGTC_694 1315-0438 43.2 µM 0.760103722437075 0.214690596407647 no 710 0.223596293885163 1009 6793154
SGTC_3281 9140613 49.47 µM 0.758864532392859 0.215076782938899 no 711 0.223966798768427 1066 16013766
SGTC_1908 st060353 56.5 µM 0.75879363828222 0.215098888875815 no 712 0.223988005911041 1115 4227716
SGTC_481 bay k-8644 50 µM 0.758509650055555 0.215187454248894 no 713 0.224072969099749 1055 2303 A calcium channel antagonist.
SGTC_1191 1487-1166 10.6 µM 0.758149212594668 0.21529989177167 no 714 0.224180830617807 1170 3955771
SGTC_2973 9094665 17.96 µM 0.757964477683484 0.215357532555583 no 715 0.224236124278158 1126 25237061 YIL048W NEO1
SGTC_2185 6113692 200 µM 0.75781393137468 0.215404512470088 no 716 0.224281190552964 1083 874150
SGTC_143 4032-1194 15.74 µM 0.757232971628243 0.215585864175208 no 717 0.224455149970981 1111 1806963
SGTC_3286 9117135 37.221 µM 0.756964803574595 0.215669605054846 no 718 0.224535474573177 1092 3438150
SGTC_2937 9044753 11.33 µM 0.756221098172063 0.215901940704834 no 719 0.224758322590483 1142 6465530 YGL099W LSG1
SGTC_2023 5144124 124 µM 0.756081732289254 0.215945495126681 no 720 0.224800096906876 1084 2830192
SGTC_1126 isoteolin 1.0172 µM 0.755634795565867 0.216085205473486 no 721 0.224934093936381 1119 133323
SGTC_1559 coumarin 343 70.1 µM 0.754640832744009 0.216396101254713 no 722 0.22523225824129 1084 108770 A hepatotoxic, DNA x-linker.
SGTC_2747 doxorubicin 7.63 µM 0.753100395756435 0.216878436629574 no 723 0.225694793313517 985 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1609 st001574 46.4 µM 0.75242301554303 0.217090731755539 no 724 0.225898355001929 1127 3960012
SGTC_1621 st003705 32.4 µM 0.752070742513443 0.217201183732191 no 725 0.226004258714383 1144 24207032
SGTC_2628 lathosterol 100 µM 0.751992957730571 0.217225576811773 no 726 0.226027646907656 1166 6710616
SGTC_1441 4106-0040 13 µM 0.751109436675039 0.217502757462948 no 727 0.226293398490957 1119 2904180
SGTC_2436 5633522 8.09 µM 0.750965133212924 0.217548048128577 no 728 0.226336819848211 1123 5724242
SGTC_1449 4112-4002 201 µM 0.750826415008337 0.217591590952296 no 729 0.226378565020253 1093 2059539
SGTC_3065 9113888 49.47 µM 0.750709180817556 0.217628393992347 no 730 0.226413848289345 1105 16648368
SGTC_668 1682-0499 62.6 µM 0.748053862174053 0.218462933166687 no 731 0.227213834866102 1135 682214
SGTC_2789 5281112 71.43 µM 0.745710452568748 0.219200971116661 no 732 0.227921171807352 1107 765948
SGTC_1881 5652484 16 µM 0.744899218058309 0.219456796470911 no 733 0.228166323943138 1092 2255129
SGTC_1888 azatryptophan 97.5 µM 0.74487718837947 0.219463745990827 no 734 0.22817298329946 1051 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3026 9090633 49.47 µM 0.744683240458742 0.219524934587437 no 735 0.228231616573708 1132 25236842
SGTC_308 4092-1169 104 µM 0.744096436341955 0.219710124984158 no 736 0.228409067554557 1124 2268590 YDL196W YDL196W
SGTC_2207 7258803 200 µM 0.742255061622254 0.220291829218385 no 737 0.228966406741896 1088 3666799
SGTC_2165 5727197 32.143 µM 0.741810001119731 0.220432559594332 no 738 0.229101230112776 1208 1361712
SGTC_842 0271-0008 11.1 µM 0.739357214962047 0.221209066847304 no 739 0.229845057631277 1143 1221709
SGTC_1998 st075797 76.8 µM 0.738233331182109 0.221565390010502 no 740 0.230186335783895 1150 24208315
SGTC_3112 9123419 49.47 µM 0.738065271694171 0.221618700825732 no 741 0.230237393020115 1185 17015854
SGTC_2102 5377816 72.7585 µM 0.737763306056901 0.221714506956553 no 742 0.230329147466087 1164 1379702
SGTC_51 1013-0126 23.419 µM 0.737356969253925 0.221843464781104 no 743 0.230452648109393 1134 1627850
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.734365928316939 0.222794039326184 no 744 0.231362873276455 1088 77254
SGTC_2200 6600604 21.907 µM 0.733718385694152 0.223000138286047 no 745 0.23156019531998 1113 2904777
SGTC_857 0438-0306 1.35 µM 0.733177295132285 0.223172439078413 no 746 0.231725150740026 1132 4686136
SGTC_529 4076-0302 30.3 µM 0.732969331422066 0.223238681628774 no 747 0.231788567413729 1082 5816522
SGTC_3024 9090631 49.47 µM 0.732931645909027 0.223250686769335 no 748 0.231800060308615 1111 25236383
SGTC_3163 9099914 49.47 µM 0.732206217514864 0.223481851683912 no 749 0.232021354988311 1132 16268368
SGTC_601 0986-0029 62.9 µM 0.732123812833257 0.223508119358128 no 750 0.232046500286111 1124 24747981
SGTC_2787 5284540 71.43 µM 0.730626237132448 0.223985798968484 no 751 0.232503740822345 1131 736958
SGTC_2161 5662504 8.5105 µM 0.730589860541241 0.223997409169567 no 752 0.232514853569873 1096 2859334
SGTC_870 0573-2213 57.6 µM 0.730548636592786 0.224010566899546 no 753 0.232527447501914 1143 3916321
SGTC_359 0081-0058 15.9 µM 0.729691564988127 0.224284223759346 no 754 0.232789369106414 1158 3494159
SGTC_1579 chlormadinone acetate 49.4 µM 0.725395538179347 0.225658771010933 no 755 0.23410470477286 1171 45114258 A steroidal progestin.
SGTC_522 1273-0010 11.6 µM 0.724863307223851 0.225829393650838 no 756 0.234267946590194 1204 5705015
SGTC_3160 9100216 49.47 µM 0.72476147714201 0.225862046659386 no 757 0.23429918631527 1127 17191039
SGTC_1163 k060-0048 49.9 µM 0.724723576018951 0.225874200780243 no 758 0.234310814319491 1176 6809982
SGTC_670 4204-0025 119 µM 0.723072153932516 0.226404137338948 no 759 0.234817778027663 1162 719039
SGTC_228 caffeine 993.056 µM 0.7195235265308 0.22754525372156 no 760 0.235909205895244 1143 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_577 r071-0003 38.6 µM 0.718298097432867 0.227940060569966 no 761 0.236286751513497 1215 4568517 YMR134W ERG29
SGTC_1208 2323-2347 50.3 µM 0.717154458342677 0.228308863829445 no 762 0.236639398168026 1164 5412760
SGTC_3330 9141424 71.43 µM 0.71590171781462 0.228713234981907 no 763 0.237026018840309 1171 27261020
SGTC_2568 diosmetin 100 µM 0.715021991464919 0.228997441356948 no 764 0.237297727261717 1167 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_530 4358-1714 28 µM 0.712684743253301 0.229753479741466 no 765 0.238020429704623 1161 1564641
SGTC_2678 equilin 100 µM 0.712312559853105 0.229874000174129 no 766 0.238135624094004 1195 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3308 9128332 17.569 µM 0.712233823974104 0.229899500962189 no 767 0.238159997530329 1185 17332805 YDL196W YDL196W
SGTC_1241 0364-0022 50.8 µM 0.711665959940348 0.230083466296085 no 768 0.238335825689321 1161 4563895
SGTC_563 tetrahydrosecaminediol 614 µM 0.711131694386485 0.230256622235658 no 769 0.23850131561526 1214 334274 A psychoactive constituent of the cannabis plant.
SGTC_777 1315-0167 517 µM 0.711038525481907 0.230286825821448 no 770 0.238530181327815 1139 4221767
SGTC_2936 9038235 15.59 µM 0.710816487351006 0.230358815289215 no 771 0.238598981182585 1177 4749415
SGTC_2823 7987624 58.44 µM 0.709505574322023 0.230784097428086 no 772 0.239005396761128 1182 2239440
SGTC_2810 7959871 45.46 µM 0.708377334067587 0.231150468309137 no 773 0.239355482064454 1187 2974535
SGTC_83 0170-0301 39.027 µM 0.707859143171732 0.231318847955025 no 774 0.239516367002742 1121 3089716
SGTC_3213 9129884 49.47 µM 0.707717809116994 0.231364784558528 no 775 0.239560257835344 1132 17190742
SGTC_392 N-ethylmaleimide 8.33 µM 0.706066087548743 0.231902006534786 no 776 0.240073519967882 1144 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2466 5983409 37.09 µM 0.705994602540586 0.231925272687236 no 777 0.24009574701296 1138 2879657
SGTC_1705 st027868 56.3335 µM 0.705712128477664 0.232017221947495 no 778 0.240183588482911 1195 292948
SGTC_2761 levamisole 97.89 µM 0.705651706462322 0.232036892793744 no 779 0.240202380299991 1168 26879 An alkaline phosphatase inhibitor.
SGTC_753 1322-0200 289 µM 0.705570700067007 0.232063266498101 no 780 0.240227575310711 1208 5403907
SGTC_2004 4023728 41.89 µM 0.703383409272576 0.232776025519866 no 781 0.240908421474378 1165 360084 YDR527W RBA50
SGTC_2725 haloperidol 53.21 µM 0.701933237912414 0.233249253783462 no 782 0.241360399729452 1163 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2666 tannic acid 100 µM 0.70105633515087 0.233535668595036 no 783 0.241633929397849 1212 16134267 A thiamine antagonist.
SGTC_216 k038-0035 28.382 µM 0.699436589690649 0.234065223908474 no 784 0.242139613995215 1141 4444231 YPR107C YTH1
SGTC_2929 9013348 24.6 µM 0.695511675696215 0.235351178927068 no 785 0.243367348362493 1187 2995952
SGTC_2780 5215298 71.43 µM 0.693088320235165 0.236147107957061 no 786 0.244127063473748 1206 2834131
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.692740763616353 0.236261381214667 no 787 0.244236126263216 1183 521171
SGTC_2022 5136654 200 µM 0.691984228220565 0.236510227992238 no 788 0.244473616820176 1191 1713771
SGTC_2733 amorolfine 100 µM 0.691703165898813 0.236602714404022 no 789 0.244561879206847 1205 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3105 9121040 49.47 µM 0.689933662309631 0.237185444280684 no 790 0.245117952821589 1064 41448907
SGTC_1255 0566-0045 221 µM 0.689290585154505 0.237397416512627 no 791 0.245320210744015 1209 2788469
SGTC_293 4049-0273 38.5 µM 0.688509796316781 0.237654921257794 no 792 0.245565901696665 1130 1380311
SGTC_3334 9142812 21.919 µM 0.685801949108971 0.238549157540805 no 793 0.24641900352643 1224 45283678
SGTC_662 k832-1615 104 µM 0.682992765639203 0.23947880213315 no 794 0.247305706943928 1193 5878478
SGTC_3076 9116187 49.47 µM 0.681843426599226 0.23985972300085 no 795 0.247668980633781 1165 27241210
SGTC_2300 7976697 71.57 µM 0.681130049265487 0.240096320947188 no 796 0.247894602371181 1147 2236109
SGTC_3270 9137563 49.47 µM 0.678229286727583 0.241059693815066 no 797 0.248813163061674 1189 17015724
SGTC_2999 9069765 71.4286 µM 0.677513443717808 0.241297755520561 no 798 0.249040121644016 1240 2097066
SGTC_2416 tofa 880 nM 0.67621099405989 0.241731227397259 no 799 0.249453346677298 1165 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2327 6189656 200 µM 0.675530130428449 0.241957995617089 no 800 0.249669507566197 1256 5349088
SGTC_1323 1348-1351 11.2 µM 0.675314547992984 0.242029821478373 no 801 0.249737971504954 1183 6989654
SGTC_131 0141-0277 33.849 µM 0.675308495947949 0.242031838012404 no 802 0.249739893636745 1189 1547771
SGTC_1807 st050092 58.9 µM 0.674490759476595 0.242304390581319 no 803 0.249999679274407 1193 5008496
SGTC_738 1315-0003 72.4 µM 0.671931936149246 0.243158323048582 no 804 0.250813514037998 1238 6251474
SGTC_1360 1598-0022 39.8 µM 0.671737874925255 0.243223151623202 no 805 0.250875292456768 1259 761525
SGTC_1183 1254-0324 198 µM 0.671149808941813 0.243419659450553 no 806 0.251062549493454 1250 5799357
SGTC_2751 anetholtrithion 17.25 µM 0.669682446644229 0.243910366324585 no 807 0.251530121909705 1214 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3161 9100388 49.47 µM 0.669486860408295 0.243975813441356 no 808 0.251592479852127 1275 25236368
SGTC_2687 chenodiol 100 µM 0.668609391313345 0.244269548936447 no 809 0.251872340134472 1249 5702181 A cholesterol synthesis inhibitor.
SGTC_637 1181-0519 7.26 µM 0.668361808918453 0.244352462378824 no 810 0.251951333858123 1256 6252091 YGR060W ERG25
SGTC_1973 st070275 50.2 µM 0.668185624308095 0.244411474487623 no 811 0.252007555341689 1190 17118334
SGTC_702 1488-0190 94 µM 0.66708355041787 0.244780782540235 no 812 0.252359383372051 1239 949357
SGTC_1730 st033808 45.1 µM 0.665050275780007 0.245462926182826 no 813 0.253009168476085 1237 1045166
SGTC_3108 9121785 49.47 µM 0.664908858748548 0.245510408167432 no 814 0.253054394639179 1212 17140271
SGTC_923 1900-2434 73.3 µM 0.663078534083918 0.246125400405304 no 815 0.253640128905787 1236 5910570
SGTC_2636 apigenin dimethyl ether 100 µM 0.662127801864223 0.246445173824443 no 816 0.253944659760722 1254 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1384 3089-0840 101 µM 0.662079673585439 0.246461367417789 no 817 0.253960080922504 1233 1069836
SGTC_3150 9097574 49.47 µM 0.661036840936545 0.246812386513405 no 818 0.254294343808725 1238 17217476
SGTC_3049 9092223 49.47 µM 0.659551640698931 0.247312768870313 no 819 0.254770798225068 1215 8623917
SGTC_1684 st024538 14.6195 µM 0.659198519325078 0.247431819586182 no 820 0.254884148811309 1235 6732859
SGTC_771 0250-0039 27.3 µM 0.659026418589153 0.247489852422861 no 821 0.254939402042517 1242 3005115
SGTC_1008 4106-0037 6 µM 0.658211630682845 0.247764699818854 no 822 0.255201076128567 1232 2905394
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.658013458166293 0.247831572766501 no 823 0.255264741662803 1295 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2593 nobiletin 86.24 µM 0.656523140733246 0.248334786159248 no 824 0.255743791685781 1214 72344 An anti-infammatory.
SGTC_2363 9053361 176 µM 0.656122766740987 0.248470067271458 no 825 0.255872568482034 1304 6469797 YMR079W SEC14
SGTC_1646 st011709 75.6 µM 0.654653504999677 0.24896684781348 no 826 0.256345433487943 1221 5757843
SGTC_908 3448-7491 47.7 µM 0.653812294594107 0.249251512067716 no 827 0.25661637227572 1273 1203031
SGTC_1727 st034309 9.9045 µM 0.653618976484744 0.249316955054515 no 828 0.256678657639502 1300 870305
SGTC_1312 1218-2183 165 µM 0.653362157989965 0.249403908627429 no 829 0.25676141443187 1275 6744073
SGTC_646 4092-0839 27.3 µM 0.65334011759842 0.249411371811321 no 830 0.256768517340465 1299 877796
SGTC_357 1325-0123 420 µM 0.653150893095406 0.249475450750273 no 831 0.256829502513985 1251 1098503
SGTC_452 diindolylmethane 8 µM 0.653115212643231 0.24948753455007 no 832 0.256841002813215 1248 3071 Inhibits expression of several cancer promoting factors.
SGTC_1112 tnp00069 1.16933 µM 0.653101812979567 0.249492072657339 no 833 0.256845321777864 1311 145826
SGTC_3050 9093513 49.47 µM 0.65268359661483 0.249633733387431 no 834 0.256980139807187 1259 25236664
SGTC_3332 9141069 11.198 µM 0.651550375716389 0.250017799328591 no 835 0.257345634721212 1227 17332883
SGTC_2108 5365811 200 µM 0.651460826565732 0.250048162270204 no 836 0.257374528298647 1291 780283
SGTC_2080 5212524 12.4 µM 0.650958789715085 0.250218421386556 no 837 0.257536544749459 1237 260183
SGTC_2315 7733312 200 µM 0.650864997018494 0.250250236745736 no 838 0.257566819235459 1242 726316
SGTC_2876 9059903 25.97 µM 0.649354748061677 0.250762822519461 no 839 0.258054553041218 1257 6916095
SGTC_1975 st070967 30.8 µM 0.648880033519297 0.250924057684459 no 840 0.258207960640672 1267 261391
SGTC_1071 trifluoperazine 6.31 µM 0.647668582802569 0.251335771313004 no 841 0.258599664268317 1315 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3183 9108214 49.47 µM 0.647108239056991 0.251526325831063 no 842 0.258780946663298 1195 4974831
SGTC_114 0364-0001 490.298 µM 0.646373608394859 0.25177626520386 no 843 0.25901871395156 1257 4003655
SGTC_2902 5787006 60.46 µM 0.646262856762018 0.251813956998082 no 844 0.259054569129494 1253 591003
SGTC_10 0279-0212 42.575 µM 0.644378900619346 0.252455574603053 no 845 0.259664881578969 1288 39851 YBR002C RER2
SGTC_618 k072-0232 33.2 µM 0.644027820732191 0.252575236793824 no 846 0.259778696801129 1268 5872756 YGL099W LSG1
SGTC_726 3448-4391 34.2 µM 0.643664618283104 0.252699062281366 no 847 0.259896469074857 1360 1356692
SGTC_2701 st077767 14.721 µM 0.643610294361373 0.252717585515992 no 848 0.259914086554251 1283 5721188
SGTC_2764 methyldopa 94.69 µM 0.6422516963544 0.25318106930526 no 849 0.260354885937673 1308 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_21 0849-0113 22.993 µM 0.641486571852294 0.253442287083439 no 850 0.260603301259003 1249 1560156
SGTC_1371 2421-0008 32.7 µM 0.640131662933526 0.253905207798615 no 851 0.261043502844865 1275 2827552
SGTC_478 N-arachidonylglycine 10 µM 0.639692125998746 0.2540554760834 no 852 0.261186387771502 1232 5283389
SGTC_2978 9011784 42.97 µM 0.638875826723714 0.254334675094149 no 853 0.261451857414593 1349 2994934
SGTC_223 busulfan 5 mM 0.638855704256046 0.25434155961664 no 854 0.261458403215223 1294 2478 A DNA alkylator.
SGTC_2963 9082507 9 µM 0.638524076457021 0.254455033877628 no 855 0.261566293230247 1305 16459611
SGTC_3071 9117417 49.47 µM 0.636237779321351 0.255238065598502 no 856 0.262310726286516 1233 45595590 YGL055W OLE1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.633605516680415 0.256141144493529 no 857 0.263169149831607 1289 4330530
SGTC_2490 carminic acid 95.39 µM 0.633382198733997 0.25621783721093 no 858 0.263242043425244 1254 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2247 cerulenin 830 nM 0.633332966942559 0.256234746194629 no 859 0.263258114645894 1344 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2897 9048598 12.99 µM 0.633154828035496 0.256295934038631 no 860 0.263316270478218 1272 6467404
SGTC_2393 9031399 185.94 µM 0.632685627082891 0.25645713344676 no 861 0.263469478803917 1333 1526623 YDL150W RPC53
SGTC_307 1501-1223 22.3 µM 0.63263110492819 0.256475868588138 no 862 0.26348728488958 1267 2830329
SGTC_212 3807-4682 38.772 µM 0.632301827039337 0.256589031652505 no 863 0.263594834968553 1370 3125501 YBL034C STU1
SGTC_2167 5876490 200 µM 0.631795467653005 0.256763103115026 no 864 0.263760267819979 1394 686534
SGTC_2387 9077560 195.08 µM 0.630298880508012 0.257277944868076 no 865 0.26424952765133 1265 5303272
SGTC_1352 1496-0991 99 µM 0.630170585439261 0.257322104681718 no 866 0.264291490991861 1290 3000039
SGTC_2965 9082772 38.63 µM 0.630055859058745 0.257361597420153 no 867 0.264329019097033 1323 16459634
SGTC_2312 7706453 155.7 µM 0.629969831189088 0.257391213217311 no 868 0.264357161422392 1314 976098
SGTC_2837 9008476 45.46 µM 0.62944406931057 0.257572249515904 no 869 0.264529187219035 1325 2992805
SGTC_1044 1222-0021 1.78 µM 0.62921638448095 0.257650669055775 no 870 0.26460370185371 1303 4306703
SGTC_1088 bifonazole 369 nM 0.627913019840126 0.258099814278173 no 871 0.26503046066833 1244 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.627133482101761 0.258368640334658 no 872 0.265285870601916 1313 5282362
SGTC_611 3453-1652 23.7 µM 0.626421155738758 0.258614415130155 no 873 0.265519368419749 1305 1560575
SGTC_2927 9011802 47.9 µM 0.625894159403421 0.258796323166421 no 874 0.265692182847773 1283 43912568
SGTC_2519 cryptotanshinone 88.04 µM 0.622360244172843 0.260017864835932 no 875 0.266852507865907 1289 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_747 3448-8087 38.7 µM 0.622134700039459 0.260095927776547 no 876 0.266926649805638 1314 5168703
SGTC_2054 5233173 129 µM 0.620791212199061 0.260561171729694 no 877 0.267368503003354 1336 6889
SGTC_1010 4112-3296 15.2 µM 0.620682533185814 0.260598825518146 no 878 0.267404262041019 1341 704384
SGTC_1958 st076513 41.9 µM 0.620509539839253 0.260658767935494 no 879 0.26746118762555 1260 732122 YGL099W LSG1
SGTC_608 k048-0125 159 µM 0.619517327547992 0.261002707795105 no 880 0.267787805268862 1348 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_660 4031-1742 102 µM 0.61874512296225 0.261270545696792 no 881 0.268042139490881 1240 6738706
SGTC_229 benomyl 22.8748 µM 0.618700267087398 0.261286108222231 no 882 0.268056917011498 1293 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1117 retinoic acid 1.10837 µM 0.617835349140023 0.261586280349344 no 883 0.268341939632818 1345 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1686 st019653 115.5 µM 0.615022007738254 0.26256388090548 no 884 0.269270093265336 1345 97252
SGTC_1640 st009078 66.4 µM 0.613158451852687 0.263212470975894 no 885 0.269885787014548 1353 690618
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.613062729377346 0.26324580821259 no 886 0.269917431449155 1357 5024745
SGTC_2453 5731132 22.18 µM 0.612463853172719 0.263454427584389 no 887 0.270115453212112 1390 1362040
SGTC_328 k915-0120 63.5 µM 0.612333045003692 0.263500006021831 no 888 0.270158715332207 1331 6624543
SGTC_1025 k007-0731 70 µM 0.611452517200997 0.26380691938738 no 889 0.27045002200256 1294 6256118
SGTC_605 1315-0399 119 µM 0.611339965621305 0.263846163065666 no 890 0.270487268964662 1370 24020461
SGTC_710 3448-4187 58 µM 0.607505150153318 0.265185035004065 no 891 0.271757862917304 1357 3946412
SGTC_384 k007-0144 5.16 µM 0.606572352252096 0.265511229175239 no 892 0.272067376503 1351 6824886
SGTC_833 3852-0053 558 µM 0.606151949199816 0.265658308268231 no 893 0.272206928578492 1401 3123681
SGTC_203 k066-0004 30.888 µM 0.60579800202713 0.265782169626347 no 894 0.272324448316233 1394 6795412
SGTC_1350 1495-0454 146 µM 0.60457911216002 0.266208935541624 no 895 0.27272934446492 1377 1069057
SGTC_744 1594-0068 283 µM 0.603284722390341 0.266662515482634 no 896 0.273159647281243 1350 668392
SGTC_3044 9093193 49.47 µM 0.602318890319113 0.267001216610979 no 897 0.273480944436738 1298 25236277
SGTC_2235 salicylic acid 500 µM 0.60135681156946 0.267338817375444 no 898 0.273801178876062 1347 338 A COX inhibitor and kinase inhibitor.
SGTC_1965 Pectolinarigenin 58.4 µM 0.601280589981018 0.267365573315644 no 899 0.273826557674344 1321 5320438 An anti-inflammatory.
SGTC_3266 9136860 49.47 µM 0.600709498373394 0.267566085642111 no 900 0.27401674577141 1277 4871271 YPR165W RHO1
SGTC_2415 st077333 57.7 µM 0.600251275261751 0.267727024232501 no 901 0.27416939296319 1449 2766255
SGTC_2262 9014885 67.46 µM 0.597139143638041 0.268821366197457 no 902 0.275207242824436 1303 6457424
SGTC_1638 st008370 60.6 µM 0.595259356376737 0.26948345632614 no 903 0.275835059678063 1328 24207134
SGTC_1175 0741-0056 27.6 µM 0.593911401570131 0.269958729496177 no 904 0.276285686385043 1427 765927
SGTC_1676 st018489 23.4 µM 0.593388201976042 0.270143316530297 no 905 0.276460691366705 1366 3696235
SGTC_3223 9129970 49.47 µM 0.591677073955489 0.27074745027284 no 906 0.277033425728511 1409 17248386
SGTC_2193 5925765 200 µM 0.591590247477588 0.270778123347814 no 907 0.277062503031168 1366 877370
SGTC_3238 9133470 49.47 µM 0.591281001231857 0.270887384450185 no 908 0.277166078579977 1418 3534688
SGTC_2323 6148992 148.28 µM 0.590179896296966 0.271276599053114 no 909 0.277535024340672 1311 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_39 0986-0283 58.349 µM 0.58915509336352 0.271639092964087 no 910 0.277878619181195 1419 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2015 5119600 184 µM 0.588808421897858 0.271761772370132 no 911 0.277994897806663 1399 2828786
SGTC_2684 capsaicin 100 µM 0.587286532871117 0.272300661440909 no 912 0.278505642124658 1340 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_63 0099-0242 26.702 µM 0.582321955266148 0.274062262262182 no 913 0.280174919808908 1352 3898502 YLR359W ADE13
SGTC_1445 4239-0156 97.7 µM 0.581940303655307 0.27419791794952 no 914 0.280303445821415 1497 4008346
SGTC_373 0844-0104 25.9 µM 0.581656834095389 0.274298696897994 no 915 0.280398926262602 1376 5375804
SGTC_1168 k815-0004 80.5 µM 0.581303385395838 0.274424380405891 no 916 0.28051799968022 1338 642433
SGTC_477 mead ethanolamide 10 µM 0.580983015498725 0.274538325909971 no 917 0.28062595031216 1289 16061185
SGTC_2220 6782180 200 µM 0.580881920931779 0.274574286914789 no 918 0.280660018927368 1332 833803
SGTC_969 1313-0238 134 µM 0.578940115091433 0.275265469907935 no 919 0.281314790632269 1395 5212874
SGTC_399 oxolinic acid 75 µM 0.578187142400916 0.275533719705744 no 920 0.281568889256085 1341 4628 A DNA gyrase inhibitor.
SGTC_2520 obtusaquinone 4.71 µM 0.577041682616289 0.275942041137043 no 921 0.281955648975294 1452 5967872
SGTC_2097 5376186 200 µM 0.575103903278061 0.276633476268154 no 922 0.282610514138195 1387 742755
SGTC_2894 9048625 32.47 µM 0.575059463141041 0.276649343276875 no 923 0.282625541085008 1469 4092861
SGTC_443 clozapine 122 µM 0.5746310024012 0.276802344760128 no 924 0.282770440100135 1319 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2081 5214970 32.255 µM 0.57365268780084 0.27715185197718 no 925 0.283101425182666 1390 2063512
SGTC_2515 chrysin 20.77 µM 0.573483359127782 0.277212367307892 no 926 0.283158731620151 1433 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_5 0352-0601 109.883 µM 0.570147867006018 0.278405734218944 no 927 0.284288705862814 1326 762456
SGTC_104 0074-0074 590.992 µM 0.568233913070909 0.279091634092719 no 928 0.284938073311593 1273 3943124
SGTC_3164 9100705 49.47 µM 0.567510253636156 0.279351184382417 no 929 0.285183781102541 1435 17174235
SGTC_823 0417-1665 178 µM 0.566267675207612 0.279797125383787 no 930 0.285605915504628 1419 3429856
SGTC_844 0330-0132 15.3 µM 0.565492161970753 0.280075619271897 no 931 0.285869527012938 1411 2828079
SGTC_3141 9094609 49.47 µM 0.565447776539971 0.280091562549476 no 932 0.285884617953541 1343 25236309 YDL196W YDL196W
SGTC_1390 3413-2614 145 µM 0.56477125867758 0.280334622665512 no 933 0.286114679282668 1387 3421432
SGTC_1220 1838-0075 193 µM 0.563712425320079 0.280715246451855 no 934 0.286474929911956 1340 5529645
SGTC_2913 7966556 36.57 µM 0.562231919743466 0.281247869454265 no 935 0.286979008147427 1413 2976516
SGTC_1275 0867-0008 21.1 µM 0.561487152344234 0.281515989463116 no 936 0.287232743127225 1408 3422836
SGTC_1276 0871-0068 94.2 µM 0.560949458816788 0.281709638451225 no 937 0.287415996035569 1424 3414906
SGTC_7 0192-1582 4.227 µM 0.560634496742025 0.281823101078033 no 938 0.287523364861306 1423 252616
SGTC_1748 st037455 53.6035 µM 0.560355705552169 0.281923551797052 no 939 0.28761841905259 1416 580690
SGTC_994 3910-0338 138 µM 0.560267585627897 0.281955305705221 no 940 0.287648466735766 1495 3479481
SGTC_2141 5621638 7.665 µM 0.560200843378441 0.281979357340666 no 941 0.287671225912947 1473 2856238
SGTC_2347 9049783 174.81 µM 0.560161327609774 0.2819935979447 no 942 0.287684701232641 1448 6467988 YPL169C MEX67
SGTC_159 3970-0959 50 µM 0.558662614093311 0.282533956501941 no 943 0.288195999385442 1457 6615653
SGTC_1242 0402-0103 60.1 µM 0.558640558750963 0.282541912232892 no 944 0.288203526942228 1349 432868
SGTC_3013 9080133 71.4286 µM 0.557221541028827 0.283054001915634 no 945 0.288688036930648 1464 17050193
SGTC_2184 6075246 200 µM 0.555576484349328 0.283648220654092 no 946 0.289250205402254 1422 2267320
SGTC_2237 6667747 47.222 µM 0.552462510557028 0.284774667252195 no 947 0.290315756408668 1414 729940 YDL015C TSC13
SGTC_175 3793-3120 23.7 µM 0.551227542371103 0.285221994192052 no 948 0.290738850860426 1396 5322297
SGTC_2986 9022445 71.43 µM 0.5510993353643 0.285268452175345 no 949 0.290782790510201 1447 6459286
SGTC_162 k030-0015 37.8 µM 0.54990656366701 0.285700845934103 no 950 0.291191731027904 1498 1809920 YMR134W ERG29
SGTC_526 4469-0568 170 µM 0.549080811186332 0.286000373444883 no 951 0.291474996595528 1395 2901964
SGTC_1351 1496-0003 46.5 µM 0.545948743824817 0.28713783152641 no 952 0.292550585414489 1427 3891978
SGTC_2443 5493264 126.67 µM 0.542458809262473 0.288407771677897 no 953 0.293751237988187 1495 5340055
SGTC_829 1635-0120 117 µM 0.541815703954055 0.288642077619993 no 954 0.293972735983659 1495 285054
SGTC_1941 st076221 61.8 µM 0.541723690133004 0.288675608830238 no 955 0.294004433649925 1405 2828568
SGTC_249 wiskostatin 11.211 µM 0.540097174486739 0.289268638029065 no 956 0.294565009582568 1444 2775510 A n-wasp and actin depolymerizer.
SGTC_2444 5485484 36.41 µM 0.539415901350663 0.289517200913152 no 957 0.294799955699826 1528 6790631
SGTC_1529 apigenin 74 µM 0.539121717220851 0.28962456515547 no 958 0.29490143571691 1515 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3253 9135987 49.47 µM 0.534073393459903 0.291469886451797 no 959 0.296645378473897 1426 4182430
SGTC_1901 st060216 58.6 µM 0.533575661839297 0.291652119642614 no 960 0.296817575300551 1421 688792
SGTC_2954 9074818 52.69 µM 0.533243036396063 0.291773932534723 no 961 0.296932676962922 1469 16648742
SGTC_182 3448-4371 550.524 µM 0.532015252075644 0.292223772409017 no 962 0.297357715983401 1516 3491403
SGTC_2382 9035899 200 µM 0.531125590300587 0.292549931240173 no 963 0.297665876020583 1440 6462679
SGTC_366 0181-0206 4.31 µM 0.529088646725508 0.293297331293053 no 964 0.298371978427864 1559 274874
SGTC_1607 st000305 50.6 µM 0.529080068126679 0.293300480842986 no 965 0.298374953793492 1480 5457690
SGTC_3261 9137475 49.47 µM 0.529029415701544 0.293319077712511 no 966 0.298392522145755 1404 17027690
SGTC_728 3030-5151 22.5 µM 0.528215797505552 0.293617869786137 no 967 0.298674783019098 1468 3125388
SGTC_612 0302-0167 22.4 µM 0.528124040620356 0.293651575303428 no 968 0.298706622984105 1528 235821
SGTC_1909 st060837 51.5 µM 0.527520471346694 0.293873332060575 no 969 0.298916102112659 1408 678937
SGTC_53 0973-0023 39.979 µM 0.527184604524035 0.293996766074362 no 970 0.299032699379599 1435 674768
SGTC_2451 5856223 45.7 µM 0.526963651872348 0.29407798118779 no 971 0.299109415075671 1407 2179896
SGTC_2752 diclazuril 33.15 µM 0.525776476842655 0.29451452611364 no 972 0.299521760143164 1472 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1948 st076329 66.6 µM 0.525513968933412 0.294611095202211 no 973 0.299612972577261 1369 24208413
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.523558224344517 0.295331016609511 no 974 0.300292922094955 1398 6312947
SGTC_9 0092-0002 10.449 µM 0.522486560377305 0.295725845607245 no 975 0.300665800751687 1445 759368
SGTC_3192 9110362 49.47 µM 0.522463819763372 0.295734226470877 no 976 0.300673715467522 1508 16649480
SGTC_2844 9010103 25.97 µM 0.521253132372604 0.296180572694886 no 977 0.301095222666476 1442 2480525
SGTC_812 4251-0442 148 µM 0.520915344431225 0.296305160682358 no 978 0.301212872815023 1452 5723007
SGTC_1438 4092-1045 4 µM 0.519551859083481 0.296808305798963 no 979 0.30168797949406 1436 1351342
SGTC_1299 1079-1439 3.74 µM 0.519387284744671 0.296869062467235 no 980 0.301745348232225 1403 323161
SGTC_2035 5154463 94.595 µM 0.519294143287056 0.296903450450938 no 981 0.301777818455585 1514 2769623
SGTC_1623 st003709 20.3 µM 0.518910474198304 0.297045120941224 no 982 0.301911586634261 1431 16192618
SGTC_2955 9076254 12.21 µM 0.51756240849384 0.297543141564795 no 983 0.302381807701199 1459 16459619
SGTC_2180 6301957 200 µM 0.51718160297493 0.297683892895343 no 984 0.302514696590724 1443 845462
SGTC_2943 9068529 45.32 µM 0.515857210708798 0.298173644189112 no 985 0.302977070656896 1436 3270634
SGTC_1653 st012112 65 µM 0.51576346482942 0.298208324684902 no 986 0.303009811359272 1475 720429
SGTC_2707 st078556 66.6 µM 0.515601003288761 0.298268430308829 no 987 0.303066554721457 1495 17250899
SGTC_3257 9139206 32.98 µM 0.514919678658804 0.298520558893445 no 988 0.303304574490073 1462 4910041
SGTC_378 3970-0959 8.33 µM 0.514471887632435 0.298686319640727 no 989 0.303461055122936 1466 6615653
SGTC_305 1682-2595 20.8 µM 0.51353340446843 0.299033857706281 no 990 0.30378912512165 1487 226033
SGTC_2219 9098279 200 µM 0.512597509215742 0.299380620160171 no 991 0.304116447947559 1488 902349
SGTC_807 1315-0151 48 µM 0.512043165162742 0.299586098442703 no 992 0.304310399989437 1565 4011080
SGTC_1490 4089-0339 670 nM 0.511576925849646 0.299758968472023 no 993 0.304473568871136 1478 742542
SGTC_2771 fluoxetine 41.05 µM 0.511529732064126 0.299776469280291 no 994 0.304490087359884 1501 3386 A selective serotonin reuptake inhibitor.
SGTC_3290 9121031 71.43 µM 0.511452061912293 0.299805272605955 no 995 0.304517273873708 1432 17014854
SGTC_3353 9151644 39.2805 µM 0.510419327278998 0.300188372639652 no 996 0.304878859666794 1458 4909158
SGTC_1974 st069448 26.9 µM 0.5102630773414 0.300246353904346 no 997 0.304933583224288 1526 6323587 YNR016C ACC1
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.508625097949103 0.300854480155084 no 998 0.3055075166624 1528 688751
SGTC_2709 st078560 56 µM 0.508454360771525 0.300917901045375 no 999 0.305567369002979 1585 17250903
SGTC_431 k089-0097 107 µM 0.508149764753391 0.301031059214434 no 1000 0.30567415879465 1412 5499420
SGTC_2061 5245884 80.95 µM 0.507365164638756 0.301322628382758 no 1001 0.305949311656956 1449 573863
SGTC_588 3970-1144 52.9 µM 0.506992716106927 0.301461080336145 no 1002 0.306079964673757 1478 1888707
SGTC_1043 0916-0009 19.3 µM 0.506737044038631 0.301556139023293 no 1003 0.306169667394622 1635 3101130
SGTC_1880 MG-132 525 µM 0.505604946425026 0.30197721403971 no 1004 0.306567004230884 1528 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_259 usnic acid 108.925 µM 0.50548699431284 0.302021100610324 no 1005 0.306608415449097 1512 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3117 9124945 49.47 µM 0.505400017805764 0.302053463888637 no 1006 0.306638953178424 1360 17592065
SGTC_2394 5221648 200 µM 0.504145313124444 0.302520502852093 no 1007 0.307079633274372 1628 788586
SGTC_779 1360-0071 233 µM 0.503877020026469 0.30262041164 no 1008 0.307173899962084 1638 7566
SGTC_538 2922-0838 53.3 µM 0.503749932338621 0.302667742567958 no 1009 0.307218557573472 1600 777039
SGTC_336 4111-0029 111 µM 0.503406719898063 0.302795580829994 no 1010 0.307339174003837 1435 3131175
SGTC_2318 6029776 164 µM 0.50268461118803 0.303064627633299 no 1011 0.307593015407057 1557 818325
SGTC_1416 3966-0321 25.3 µM 0.502444291869862 0.303154190696371 no 1012 0.307677514811169 1479 582530 YLR208W SEC13
SGTC_1722 st034304 3.6505 µM 0.502377953532521 0.303178915989837 no 1013 0.307700842032336 1451 4036148 YLR033W RSC58
SGTC_128 0906-2981 13.371 µM 0.502081703876623 0.303289343684562 no 1014 0.307805024785042 1537 6740226
SGTC_1700 st030840 7.9285 µM 0.501124783561002 0.303646160549157 no 1015 0.308141652849446 1565 5499307
SGTC_2368 9071271 200 µM 0.499981434673237 0.304072738514372 no 1016 0.308544074964157 1439 27209959
SGTC_3114 9122766 49.47 µM 0.498822152627031 0.304505533552528 no 1017 0.308952339981487 1418 17176985
SGTC_2074 5212007 75.395 µM 0.498538381522009 0.304611515631211 no 1018 0.309052311807342 1524 758611
SGTC_2398 5228213 48.84 µM 0.497938900906479 0.304835461981116 no 1019 0.309263553770923 1596 80771 YMR134W ERG29
SGTC_1704 st028805 70.8 µM 0.497181062997389 0.30511867009973 no 1020 0.309530687129356 1465 2876101
SGTC_1895 st058434 18.3 µM 0.496813968936108 0.305255897113733 no 1021 0.30966012180389 1570 5393175
SGTC_2879 9041815 71.43 µM 0.49623955921003 0.305470677750332 no 1022 0.309862701828733 1449 4942971
SGTC_1720 st037298 9.481 µM 0.495975399611778 0.305569473575033 no 1023 0.309955883739127 1471 597396
SGTC_1064 honokiol 6.76 µM 0.495570242658694 0.305721029991384 no 1024 0.310098825981197 1469 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2930 9013230 14.89 µM 0.494933211945803 0.305959390358231 no 1025 0.310323632965532 1576 2995857
SGTC_1810 st050138 53 µM 0.494542385450511 0.306105668186667 no 1026 0.310461590019377 1509 3444541
SGTC_181 1447-1644 8.07 µM 0.493367772042542 0.306545486403971 no 1027 0.310876374877386 1509 534600
SGTC_417 st075190 100 µM 0.491798069324584 0.307133675660485 no 1028 0.311431050761717 1583 222757
SGTC_3262 9137218 49.47 µM 0.488937390024911 0.308206888146473 no 1029 0.312443011796204 1430 17650664
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.488067551003255 0.308533542878723 no 1030 0.312750997163447 1478 689007
SGTC_1521 st012942 49.4 µM 0.487800383773838 0.308633903887938 no 1031 0.312845619775544 1675 24207259
SGTC_2428 5615643 7.78 µM 0.487798039738724 0.308634784484842 no 1032 0.312846450016994 1531 2253075
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.48762787859067 0.308698712823451 no 1033 0.312906722485155 1539 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.486606120141221 0.30908270211622 no 1034 0.313268742804152 1575 688798
SGTC_23 0213-0011 39.996 µM 0.486461831133675 0.309136944511295 no 1035 0.31331988050938 1573 627608
SGTC_3264 9137442 49.47 µM 0.484565545046634 0.309850199416492 no 1036 0.313992279663037 1581 17015726
SGTC_1444 4112-3581 28 µM 0.483820209982983 0.310130740466999 no 1037 0.314256735414196 1512 2877249
SGTC_3316 9136639 10.545 µM 0.483574960776357 0.310223075439977 no 1038 0.314343774271211 1573 4903665
SGTC_2804 7954240 19.48 µM 0.483246962039854 0.310346583855925 no 1039 0.314460197041919 1598 828705
SGTC_1581 himbacine 57.9 µM 0.482645450448336 0.310573139523217 no 1040 0.314673750831426 1486 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_389 tpck 16.7 µM 0.4825691960394 0.310601865415087 no 1041 0.314700827753696 1498 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2095 5432005 200 µM 0.481745159660682 0.310912362811279 no 1042 0.314993495604465 1506 783734
SGTC_1355 1499-0035 1.68 µM 0.48104683428536 0.311175597663681 no 1043 0.315241606435616 1477 1548538
SGTC_154 3389-1638 511.116 µM 0.480686523336977 0.311311455235888 no 1044 0.315369655369315 1399 5238686
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.480091054175409 0.311536037069572 no 1045 0.315581324502484 1480 229346 A bile salt which induces apoptosis.
SGTC_2829 7992743 58.44 µM 0.476984319640643 0.312708881319715 no 1046 0.3166866437263 1621 16462845
SGTC_1116 jasmonic acid 1.58368 µM 0.47678957927432 0.312782462428603 no 1047 0.316755983460082 1559 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2746 daunorubicin 9.88 µM 0.474968469230481 0.313470915245071 no 1048 0.317404723735981 1525 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2755 lomerizine 42.69 µM 0.474920151239627 0.313489190254933 no 1049 0.317421943871875 1489 3949 A calcium channel blocker.
SGTC_958 1222-0007 33 µM 0.472520905301041 0.314397217020567 no 1050 0.318277511795024 1600 7312461
SGTC_3082 9117008 49.47 µM 0.472355103118196 0.314460008664333 no 1051 0.318336672528748 1524 41448529
SGTC_1155 4088-0394 48.2 µM 0.472116372230367 0.314550428874011 no 1052 0.31842186346909 1478 2326248
SGTC_3168 9103419 49.47 µM 0.471702348143039 0.314707268406353 no 1053 0.318569630422443 1512 16649256
SGTC_1575 cyproterone acetate 48 µM 0.471223923077869 0.314888545789394 no 1054 0.318740418301013 1458 9880 An androgen receptor antagonist and liver toxin.
SGTC_2320 7373003 200 µM 0.470303735002108 0.315237334521268 no 1055 0.319069014693559 1450 5415828
SGTC_1732 st034308 51.822 µM 0.469707362805089 0.315463471868327 no 1056 0.31928205338753 1496 830119
SGTC_3203 9113543 49.47 µM 0.469556880913266 0.315520543764263 no 1057 0.319335818621952 1573 17018012
SGTC_2116 5511452 16.8835 µM 0.467764797015198 0.316200549051292 no 1058 0.319976398792335 1552 870744
SGTC_1685 st024049 53.0905 µM 0.466945032516921 0.316511815784875 no 1059 0.320269602682687 1525 1941139
SGTC_808 0711-0032 135 µM 0.465113131146654 0.317207863174878 no 1060 0.320925221475405 1655 4252555
SGTC_839 0122-0028 230 µM 0.465099414755179 0.317213077284789 no 1061 0.320930132541865 1537 759448
SGTC_921 1561-0023 372 µM 0.463850564950253 0.317687963418482 no 1062 0.321377406441744 1496 24050882
SGTC_2063 5246145 200 µM 0.46348038143559 0.317828786655591 no 1063 0.321510036998598 1577 711240
SGTC_2852 9023854 51.95 µM 0.46345623468998 0.31783797334745 no 1064 0.321518689164165 1586 19798528
SGTC_2271 7849410 118.62 µM 0.462376043558168 0.318249049487066 no 1065 0.321905837931556 1576 972430
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.462234597478107 0.318302894616564 no 1066 0.32195654761799 1428 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1698 5-fluorocytosine 1.055 µM 0.461928490460761 0.318419435358048 no 1067 0.322066301075809 1596 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1348 1493-0373 93.8 µM 0.461783204184627 0.318474754885662 no 1068 0.322118398326027 1569 3010129
SGTC_1284 0929-0043 16 µM 0.461729888948882 0.318495056329302 no 1069 0.322137517162498 1517 1239883
SGTC_2463 5473429 200 µM 0.460692058977539 0.318890351045414 no 1070 0.322509776552568 1534 5399405
SGTC_1004 4084-0029 199 µM 0.460423343202544 0.318992734682326 no 1071 0.322606191282386 1635 716894 YLR208W SEC13
SGTC_442 cape 100 µM 0.459427926055248 0.31937211975363 no 1072 0.322963449040352 1649 5281787
SGTC_2708 st078559 56 µM 0.459283567394432 0.319427155138076 no 1073 0.323015273307541 1502 17250902
SGTC_2639 lactacystin 53 µM 0.457762875971879 0.320007145949484 no 1074 0.323561404929175 1619 3870 A proteasome inhibitor.
SGTC_2492 derrusnin 100 µM 0.457598655343794 0.320069805960268 no 1075 0.323620404870016 1484 1715307 Part of coumarin class of compounds.
SGTC_1244 0416-0015 52.5 µM 0.455448700977728 0.320890615299214 no 1076 0.324393232685823 1537 96201
SGTC_42 0133-0086 60.653 µM 0.454825133051787 0.321128845091703 no 1077 0.32461752369336 1447 162923 Model of phenazepam hydroxylation.
SGTC_3197 9113331 49.47 µM 0.454759551411331 0.321153904382694 no 1078 0.324641116437547 1638 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1415 3966-0071 78.1 µM 0.454722122723168 0.321168206561198 no 1079 0.324654581580271 1545 2893185
SGTC_333 3486-0131 40.1 µM 0.453842930985872 0.321504237877904 no 1080 0.324970940736713 1659 6744690
SGTC_2648 atorvastatin 78.68 µM 0.452474205327169 0.322027662157896 no 1081 0.325463699864793 1623 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2621 lithochol-11-enic acid 100 µM 0.451696724624073 0.322325141567386 no 1082 0.325743739077154 1680 6708711
SGTC_422 cantharidin 155 µM 0.450965207660495 0.322605138283305 no 1083 0.326007312517163 1487 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2049 5262831 67.185 µM 0.449454769529728 0.323183594497456 no 1084 0.326551814680065 1563 763417
SGTC_3086 9117350 49.47 µM 0.447938696756796 0.32376463887978 no 1085 0.327098719935302 1492 2679265
SGTC_1253 0550-0034 176 µM 0.44735330223497 0.323989110094912 no 1086 0.327309993540622 1543 5969915
SGTC_1606 st000094 49.2 µM 0.445237971843269 0.324800772753989 no 1087 0.328073894168527 1663 1242210
SGTC_2468 5987765 72.9 µM 0.445015408102574 0.324886220023618 no 1088 0.328154309601944 1602 26772094
SGTC_2866 9034245 58.44 µM 0.444648044858986 0.325027279261267 no 1089 0.32828706057007 1668 6462273
SGTC_3251 9135047 49.47 µM 0.442036593087627 0.326030740078344 no 1090 0.329231363119911 1659 17682963
SGTC_2585 alliin 100 µM 0.441623977399154 0.326189404871791 no 1091 0.329380665117472 1673 87310 A garlic compound which reacts with lipids.
SGTC_1503 4585-0012 61.3 µM 0.441241111457587 0.326336658019896 no 1092 0.329519226721634 1632 2922052
SGTC_1317 1273-0028 910 nM 0.440269287699822 0.326710550346618 no 1093 0.329871040969349 1562 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_984 1492-0255 2.91 µM 0.439372278307044 0.327055813673231 no 1094 0.330195904962621 1602 1585198
SGTC_1643 st009866 20.2 µM 0.437743167937934 0.327683244780941 no 1095 0.330786236494906 1630 3156273 YOR207C RET1
SGTC_758 0868-0029 16 µM 0.43756662917985 0.327751265703786 no 1096 0.330850233162006 1697 762687
SGTC_1943 st076331 65.2 µM 0.436111904997145 0.328311992812666 no 1097 0.331377770011249 1612 24208415
SGTC_3314 9135860 59.4275 µM 0.435914682953967 0.328388042364644 no 1098 0.331449315817108 1629 25252478
SGTC_609 0986-0026 86.3 µM 0.432630348566162 0.3296555370849 no 1099 0.332641668980611 1628 2848610
SGTC_2331 7980721 200 µM 0.432281345602242 0.329790340174507 no 1100 0.332768471745591 1666 2981221
SGTC_103 0844-0104 51.839 µM 0.43211554389117 0.329854389164169 no 1101 0.332828718956588 1659 5375804
SGTC_2171 5739187 198.077 µM 0.432062502310077 0.329874880112722 no 1102 0.332847993537172 1514 2262761
SGTC_3239 9133757 49.47 µM 0.431817695379044 0.32996946019482 no 1103 0.33293695873019 1634 17036923
SGTC_1992 st073643 23.3 µM 0.431792670439608 0.329979129082672 no 1104 0.33294605356377 1584 3161292
SGTC_750 4073-0104 132 µM 0.430683135994292 0.33040793407014 no 1105 0.33334939125241 1492 22330957
SGTC_62 0180-0423 3.232 µM 0.429619768177268 0.330819105992004 no 1106 0.333736127383598 1549 30102 YGL099W LSG1
SGTC_1531 st059297 52.4 µM 0.429557693434675 0.330843114715333 no 1107 0.333758708802881 1596 7566702
SGTC_1587 estradiol valerate 56.1 µM 0.428890216775752 0.331101319419056 no 1108 0.334001560090669 1689 13791 A steroid.
SGTC_1847 st056231 15 µM 0.427350297312686 0.331697323649737 no 1109 0.334562101604894 1547 5393180
SGTC_2915 7971052 15.16 µM 0.426298313062584 0.332104724585251 no 1110 0.334945243482092 1520 5741558
SGTC_1460 k062-0059 9.15 µM 0.42513137580409 0.332556875521987 no 1111 0.335370453294654 1539 1373085
SGTC_2891 9063876 19.48 µM 0.424439376217686 0.332825118434588 no 1112 0.335622704515877 1645 6472478
SGTC_3100 9120536 49.47 µM 0.424291624635064 0.332882403138048 no 1113 0.335676573280011 1609 16421196
SGTC_1055 3448-0672 86 µM 0.422796188046535 0.333462417572847 no 1114 0.336221984556421 1594 748378
SGTC_2424 5537928 59.2 µM 0.422064085672351 0.333746513397774 no 1115 0.33648912063811 1560 5382802
SGTC_2229 7354935 190 µM 0.421866503218464 0.333823202557372 no 1116 0.336561230448095 1620 318112
SGTC_1812 st052057 4.327 µM 0.421551236903422 0.333945583610645 no 1117 0.336676302676473 1551 3645418
SGTC_356 1634-0012 32.5 µM 0.419492034875766 0.334745364955378 no 1118 0.337428287332676 1700 735457
SGTC_2649 anisomycin 9.56 µM 0.419105692126464 0.334895501785617 no 1119 0.337569445444169 1592 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_623 k072-0108 16.9 µM 0.418582108455896 0.335099013989205 no 1120 0.337760783769459 1618 5382803
SGTC_3004 9076122 71.4286 µM 0.417884800799053 0.335370126301618 no 1121 0.338015672870749 1672 44782551
SGTC_1313 1220-0047 237 µM 0.416748409940739 0.335812137307296 no 1122 0.338431220589104 1670 3528706
SGTC_3323 9138564 53.9225 µM 0.416429401032499 0.335936260001824 no 1123 0.338547909012318 1732 43912313 YNL103W MET4
SGTC_263 alizarin 107.927 µM 0.415257808804086 0.336392266514088 no 1124 0.338976591897083 1635 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2252 omeprazole 400 µM 0.414922193713467 0.336522938837726 no 1125 0.339099431141919 1679 4594 A proton pump inhibitor.
SGTC_760 0568-0725 82.9 µM 0.414698361995048 0.336610099086227 no 1126 0.339181365809609 1727 3916171
SGTC_3277 9138724 49.47 µM 0.413733202099994 0.336986033601272 no 1127 0.339534754253504 1611 15943418
SGTC_3271 9137798 49.47 µM 0.412496817840913 0.337467849284618 no 1128 0.339987656308137 1710 6498326
SGTC_3171 9103192 49.47 µM 0.411387536681462 0.337900360162539 no 1129 0.340394195658004 1664 13018434
SGTC_1148 3909-7663 27.7 µM 0.411301315780477 0.337933986833982 no 1130 0.340425802447884 1681 4084526
SGTC_2667 digitoxin 100 µM 0.411133371888236 0.33799948967793 no 1131 0.340487370405261 1664 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1161 k007-0610 110 µM 0.410916541151786 0.338084067021634 no 1132 0.340566866487508 1650 5843850
SGTC_960 1222-0186 7.7 µM 0.410341359214305 0.338308462993952 no 1133 0.340777778235861 1676 3126296
SGTC_524 r073-0010 27.8 µM 0.408835310372884 0.338896290398763 no 1134 0.341330262485309 1565 2772106
SGTC_1377 2944-0135 198 µM 0.408693063011184 0.338951831416057 no 1135 0.341382462611474 1661 1894137
SGTC_391 gliotoxin 8.33 µM 0.408203526585919 0.339142999503867 no 1136 0.341562129645358 1666 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2740 felodipine 17.08 µM 0.40801253287269 0.339217595388999 no 1137 0.341632236873181 1718 3333 L-type calcium channel blocker
SGTC_3101 9120531 49.47 µM 0.407938763021776 0.339246409162569 no 1138 0.341659316712809 1702 24824904
SGTC_2288 7946289 167.31 µM 0.407228445951932 0.339523900062448 no 1139 0.341920105464613 1743 1246052
SGTC_2172 5754775 163.918 µM 0.406947918232055 0.339633514381753 no 1140 0.342023120362066 1567 2263357
SGTC_1086 cerivastatin 2.18 µM 0.404276649331381 0.340677973184032 no 1141 0.343004647279579 1654 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2452 5863136 48.41 µM 0.404198684273091 0.340708475710413 no 1142 0.343033310597287 1581 2184096
SGTC_630 4356-0227 183 µM 0.403648982801766 0.340923566779086 no 1143 0.343235430192167 1625 779312
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.403017132608132 0.341170865466318 no 1144 0.343467810434552 1684 5393153
SGTC_2748 diazoxide 86.69 µM 0.401629657765256 0.341714146013352 no 1145 0.34397829992806 1671 3019 A potassium channel activatior.
SGTC_3297 9117502 71.43 µM 0.400937178665884 0.341985416362643 no 1146 0.344233188203943 1631 7453720
SGTC_2196 6573537 42.6665 µM 0.399987364280628 0.342357627395358 no 1147 0.344582911759581 1712 2903087
SGTC_2738 aclarubicin 5.55 µM 0.397883623603147 0.343182581280948 no 1148 0.3453579860332 1677 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1615 st002656 86.5 µM 0.397187220188154 0.343455831566462 no 1149 0.345614702787975 1607 1584458
SGTC_732 3970-1727 52.7 µM 0.397170425613865 0.343462422324487 no 1150 0.345620894687028 1756 1275699
SGTC_1571 st070080 73.4 µM 0.396525668729508 0.343715482668385 no 1151 0.345858637765458 1734 4315245
SGTC_2967 9089538 49.85 µM 0.396022602900372 0.343912979408178 no 1152 0.346044176912884 1813 728216
SGTC_2491 paeonol 100 µM 0.395967308076254 0.343934689996411 no 1153 0.346064572830664 1610 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3067 9117431 49.47 µM 0.395677934611325 0.344048316040799 no 1154 0.346171317723654 1643 17150885
SGTC_1173 0443-0020 122 µM 0.395317274545792 0.344189953358386 no 1155 0.346304376126714 1611 5331295
SGTC_220 paclitaxel 373.376 µM 0.395245999580461 0.344217946832135 no 1156 0.346330673862106 1661 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1410 3909-8106 77.9 µM 0.394650129224185 0.344452010231643 no 1157 0.34655055620272 1691 1039210
SGTC_1382 3002-2117 298 µM 0.393322255543036 0.344973825530734 no 1158 0.347040741290886 1745 1497314
SGTC_153 4077-0274 519.67 µM 0.391048625044282 0.345867979936843 no 1159 0.347880647093914 1761 3121976
SGTC_1475 4092-1048 11.7 µM 0.391009837839832 0.345883241321631 no 1160 0.347894982034388 1619 2881759
SGTC_1476 4112-3294 3.34 µM 0.390855997150644 0.345943774624533 no 1161 0.347951840480307 1728 704369
SGTC_978 1416-0512 87.4 µM 0.390697190722543 0.346006265978848 no 1162 0.348010537814983 1661 6814003
SGTC_2843 9000894 45.46 µM 0.389208053067062 0.346592455119591 no 1163 0.348561123361242 1592 2242070
SGTC_3207 9114163 49.47 µM 0.388019571610928 0.34706055674098 no 1164 0.349000775030757 1826 849233
SGTC_2819 7996655 46.38 µM 0.386451372807938 0.347678573050343 no 1165 0.349581204738541 1722 6456960
SGTC_408 cantharidin 100 µM 0.385509465122987 0.348049967158561 no 1166 0.349929997613388 1670 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_86 0417-1630 471.922 µM 0.384896403959139 0.348291775471093 no 1167 0.350157085137495 1667 3634867
SGTC_244 nsc-207895 1.295 µM 0.383419581748493 0.348874528168488 no 1168 0.350704343277647 1599 42640
SGTC_594 1487-1584 10.8 µM 0.380948837620908 0.349850278524231 no 1169 0.351620606345117 1600 5013332
SGTC_2951 9072950 58.06 µM 0.380762694089926 0.349923830916981 no 1170 0.351689671750273 1686 16488155
SGTC_501 nsc-95397 161 µM 0.380473559924566 0.350038089995525 no 1171 0.351796959792919 1735 262093
SGTC_3151 9099821 49.47 µM 0.380248986323877 0.350126845614268 no 1172 0.351880299708423 1609 17174189
SGTC_430 0958-0115 16.4 µM 0.379328177866338 0.350490851618712 no 1173 0.352222088779437 1650 6833180
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.377756865291151 0.351112326260485 no 1174 0.352805609955517 1770 16725076
SGTC_210 3551-0445 56.827 µM 0.376786543282595 0.351496300381316 no 1175 0.353166120947685 1711 2865180 YOR207C RET1
SGTC_1217 1183-1422 255 µM 0.374964238265349 0.352217829132427 no 1176 0.353843531599638 1752 2849664
SGTC_2842 9000675 19.48 µM 0.374580068039936 0.352370006630618 no 1177 0.353986399456883 1568 2989072
SGTC_2569 tetrandrine 100 µM 0.372673314634211 0.353125659107983 no 1178 0.354695799903138 1602 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1353 1498-1206 8.11 µM 0.371339441031847 0.353654622200671 no 1179 0.355192362475015 1655 6756808
SGTC_852 0418-0143 439 µM 0.369930168303785 0.35421379282355 no 1180 0.35571726121659 1768 5369229
SGTC_1326 1431-2094 10.8 µM 0.369042867130777 0.354566017213712 no 1181 0.35604788653343 1631 616278
SGTC_2996 9066192 71.4286 µM 0.368637445699748 0.354726995329693 no 1182 0.356198990334797 1577 6472854
SGTC_4 0960-0234 25.671 µM 0.367326895809803 0.355247544425745 no 1183 0.35668759712567 1658 6821112
SGTC_2576 guaiol 23.12 µM 0.366487877055132 0.355580943771837 no 1184 0.357000528522206 1840 227829
SGTC_1558 st069300 45.6 µM 0.362206950815823 0.357283763425068 no 1185 0.35859869286168 1781 24208000
SGTC_3157 9099274 49.47 µM 0.361405128981493 0.357603020744151 no 1186 0.358898307188324 1815 17217662
SGTC_1505 k297-0037 20.6 µM 0.361064829703528 0.357738546113847 no 1187 0.359025492041778 1650 4089396
SGTC_2691 st077356 60.2 µM 0.359175447764082 0.358491324864913 no 1188 0.359731921336299 1780 2839272
SGTC_1942 st076330 65.2 µM 0.358902103339339 0.358600277997269 no 1189 0.359834163041817 1726 24208414
SGTC_2977 9011197 71.43 µM 0.358216769755256 0.35887349764694 no 1190 0.360090549194979 1746 2704722
SGTC_20 0481-0013 4.944 µM 0.3574116155618 0.359194578036608 no 1191 0.360391841151163 1652 182045
SGTC_280 3448-3607 3.04 µM 0.356892137768227 0.359401788846012 no 1192 0.36058627787627 1796 626179
SGTC_44 0929-0055 61.211 µM 0.354785391514415 0.360242557266117 no 1193 0.361375186631874 1637 1379590
SGTC_2182 6325192 200 µM 0.354678855729754 0.360285091978098 no 1194 0.361415096553749 1714 736248
SGTC_1236 0330-0013 258 µM 0.354646765748434 0.360297904332423 no 1195 0.361427118243351 1690 4617066
SGTC_58 0957-0393 9 µM 0.354327535547303 0.360425369802232 no 1196 0.361546717110475 1669 6997992
SGTC_1622 st003707 19.4 µM 0.354119704378698 0.360508363075923 no 1197 0.361624587855684 1727 10140899
SGTC_1446 4239-0190 62 µM 0.353991629877457 0.360559510372276 no 1198 0.361672578011084 1673 1340085
SGTC_1641 st009299 47.1 µM 0.353769126472519 0.36064837433179 no 1199 0.361755956321496 1755 4046054
SGTC_1296 1068-0102 11.9 µM 0.353508863321379 0.360752328421466 no 1200 0.361853492603696 1768 767053
SGTC_485 niflumic acid 177 µM 0.352824417621827 0.361025758242562 no 1201 0.362110038459755 1744 4488 A COX2 inhibitor.
SGTC_3309 9129340 25.759 µM 0.352497218301197 0.36115649649425 no 1202 0.362232702123031 1753 17158987
SGTC_1840 st055363 71 µM 0.352249582569861 0.361255454496541 no 1203 0.362325547620956 1622 676033
SGTC_2149 5554786 194.827 µM 0.352095709613055 0.361316948525008 no 1204 0.362383242936612 1718 745063 YPR165W RHO1
SGTC_2793 7325131 81.82 µM 0.35206165472411 0.361330558758291 no 1205 0.362396012383698 1732 4176441
SGTC_3080 9117754 49.47 µM 0.350053543452281 0.362133421801028 no 1206 0.363149257349041 1816 9550191
SGTC_2982 9019404 25.97 µM 0.349606139417351 0.362312381226841 no 1207 0.363317151389377 1507 22333232
SGTC_2341 7987486 176.74 µM 0.349254049942394 0.362453236458434 no 1208 0.363449295899873 1850 1258686
SGTC_3037 9091026 49.47 µM 0.348985324035985 0.362560754190382 no 1209 0.363550163736438 1739 25236398 YIL048W NEO1
SGTC_1 0258-0098 57.368 µM 0.348170791325624 0.362886716424706 no 1210 0.363855961108145 1691 6790032 YDR047W HEM12
SGTC_2989 9073649 71.4286 µM 0.347616665281589 0.363108525119911 no 1211 0.364064044435057 1844 21367202
SGTC_2984 9022109 38.96 µM 0.347466966397425 0.363168455314536 no 1212 0.364120265676476 1737 6459207
SGTC_3139 9095020 49.47 µM 0.347441579007834 0.363178619190856 no 1213 0.364129800510281 1638 25236292
SGTC_1799 st045822 46.1415 µM 0.346793432693332 0.363438138070401 no 1214 0.36437325563549 1820 3674992
SGTC_3275 9138069 49.47 µM 0.345887107163891 0.363801137441677 no 1215 0.364713779153045 1760 17617007
SGTC_1421 4029-0249 71.4 µM 0.344322069149663 0.364428250512047 no 1216 0.365302044538233 1852 2894095
SGTC_1472 k841-0093 193 µM 0.340707795759824 0.36587788017098 no 1217 0.366661784645146 1809 X1472
SGTC_215 1287-0124 461.5 µM 0.339608866418185 0.366319024896844 no 1218 0.367075550082247 1833 5560863
SGTC_948 3448-0295 75.3 µM 0.338340454051923 0.366828425109188 no 1219 0.36755332072451 1692 678569
SGTC_3019 9081971 49.47 µM 0.337908829011853 0.367001821245777 no 1220 0.367715946966161 1826 16451803
SGTC_1793 st048256 72.231 µM 0.337499445555155 0.367166307376222 no 1221 0.367870215017461 1724 672022
SGTC_2495 cafestol 54.53 µM 0.336587600285197 0.367532765177857 no 1222 0.368213902438136 1771 16667697 An anti-infammatory.
SGTC_894 0960-0238 55.9 µM 0.336293253213683 0.367651084906532 no 1223 0.368324868562592 1770 6741907 YDL195W SEC31
SGTC_435 c-PAF 6.7 µM 0.336239954270884 0.3676725110139 no 1224 0.368344962946096 1810 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.335241088233901 0.36807413001074 no 1225 0.368721614783917 1858 6728940
SGTC_1479 0549-0158 134 µM 0.334697284747981 0.368292840430165 no 1226 0.368926724947962 1705 5440202
SGTC_1876 myriocin 605 nM 0.332896395167696 0.369017438312816 no 1227 0.369606245320367 1843 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_840 0245-0196 390 µM 0.332856655687898 0.369033432973677 no 1228 0.369621244615713 1791 3827528
SGTC_1111 tnp00062 510.699 nM 0.332683821687191 0.369102999210106 no 1229 0.36968648150204 1838 676306
SGTC_2946 9065502 71.43 µM 0.332429472098237 0.369205383527979 no 1230 0.369782493595579 1709 16489101
SGTC_2355 9061122 103.12 µM 0.331732494756606 0.369485988028274 no 1231 0.370045630767073 1847 5302957
SGTC_2333 9017922 200 µM 0.331565233679973 0.36955333803056 no 1232 0.370108787654411 1856 3163164
SGTC_2674 ligustilide 100 µM 0.330764498459478 0.369875820638294 no 1233 0.370411189482631 1732 5319022 A signalling regulator.
SGTC_3248 9135562 49.47 µM 0.330129014847979 0.370131816102207 no 1234 0.370651240200209 1751 17650701
SGTC_1404 3909-7820 48.3 µM 0.328775476760263 0.370677261199806 no 1235 0.371162700136517 1826 23741373
SGTC_847 0342-0274 5.54 µM 0.328445426756499 0.370810303327489 no 1236 0.371287450321541 1844 18097
SGTC_1024 4507-0395 26 µM 0.32767547713203 0.371120727646458 no 1237 0.37157852349904 1752 4201836
SGTC_16 erodoxin 22.806 µM 0.326442972395796 0.37161781707419 no 1238 0.372044614683931 1754 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2075 5212009 200 µM 0.325780472723183 0.371885102635017 no 1239 0.37229522697463 1827 780898
SGTC_1631 benzylvanillin 81.9 µM 0.325328953241165 0.372067303613311 no 1240 0.372466060072684 1756 75506
SGTC_61 0978-8327 98.565 µM 0.325014536593115 0.372194196614545 no 1241 0.372585034924587 1770 6150059 YHR072W ERG7
SGTC_559 1550-0661 158 µM 0.324826625850396 0.372270040695805 no 1242 0.372656145911377 1786 5830875
SGTC_2123 5259487 200 µM 0.324726940253217 0.37231027756802 no 1243 0.372693871654087 1835 2173474
SGTC_1338 1486-1223 76 µM 0.324397020654203 0.372443455518673 no 1244 0.372818737535001 1804 3444526
SGTC_569 4130-2812 160 µM 0.323685704648866 0.372730642834678 no 1245 0.373087997366185 1849 743552
SGTC_507 nimesulide 162 µM 0.323633018936009 0.372751917024751 no 1246 0.373107943355593 1855 4495 A COX2 inhibitor.
SGTC_3200 9114385 49.47 µM 0.323625734157073 0.372754858607443 no 1247 0.373110701286078 1681 17018030 YLR208W SEC13
SGTC_997 3996-0078 137 µM 0.323194896615509 0.372928843345222 no 1248 0.37327382280357 1748 735687
SGTC_1079 idarubicin 2.36 µM 0.322707596019737 0.37312566074659 no 1249 0.37345834944972 1833 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3066 9117245 49.47 µM 0.321902475340611 0.373450916052094 no 1250 0.373763288936439 1829 17176980
SGTC_2959 9079155 11 µM 0.321702094093931 0.373531880752119 no 1251 0.373839195631953 1770 16189457
SGTC_954 1189-0853 2.85 µM 0.320070480762726 0.374191346975506 no 1252 0.374457451217376 1779 2828194
SGTC_1946 st076057 65.1 µM 0.319695398190919 0.374343000157997 no 1253 0.37459962428581 1730 953009
SGTC_289 k017-0060 526 µM 0.318490182490253 0.374830423826007 no 1254 0.375056570249543 1744 5512909
SGTC_2677 mitomycin C 100 µM 0.318327817204189 0.374896104292427 no 1255 0.375118142911297 1767 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2659 sanguinarine 24.21 µM 0.317814841167409 0.375103638648924 no 1256 0.375312696161172 1742 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_944 3370-0224 231 µM 0.315664277334669 0.375974083720248 no 1257 0.376128671925343 1697 4580514
SGTC_761 k216-0224 480 µM 0.315401042535441 0.376080672000506 no 1258 0.376228587686353 1931 1340404
SGTC_1827 berberine 7.24 µM 0.315290894857492 0.376125275488449 no 1259 0.376270398789031 1629 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1005 4092-0690 4.4 µM 0.311903531469455 0.377497768468943 no 1260 0.37755691928837 1734 1529343
SGTC_782 0083-0095 30.5 µM 0.311668867226197 0.377592907350655 no 1261 0.377646095283286 1748 3591729 An indicator and reagent.
SGTC_2679 rapamycin 1 nM 0.309848299859069 0.37833126381752 no 1262 0.378338159925652 1778 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1907 st060210 83.7 µM 0.307174104286522 0.379416626439382 no 1263 0.379355427547587 1855 688793
SGTC_1245 0418-0076 17.2 µM 0.307165140168828 0.379420266265768 no 1264 0.379358838919612 1781 6790114
SGTC_2255 7941087 197.44 µM 0.306748383488302 0.379589499617195 no 1265 0.379517449621632 1887 935561
SGTC_2706 st078239 82.5 µM 0.304700567909427 0.380421395443038 no 1266 0.380297108519494 1769 15434492
SGTC_1995 st072814 61.1 µM 0.303065487378479 0.381086021062476 no 1267 0.380919977538902 1735 5769371
SGTC_1392 3455-1037 33.9 µM 0.302179893833986 0.38144614273283 no 1268 0.38125746531228 1862 981132
SGTC_2641 levomentholum 100 µM 0.300189065637085 0.382256076274396 no 1269 0.382016472526085 1830 16666
SGTC_1954 st077032 68.9 µM 0.300057522479084 0.382309610494368 no 1270 0.382066639627713 1686 698907
SGTC_1039 k821-0043 94 µM 0.298940135912963 0.382764444784465 no 1271 0.382492861253623 1879 15992768
SGTC_441 propafenone 146 µM 0.29675764528974 0.383653297604111 no 1272 0.383325771839461 1776 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2028 5153890 36.43 µM 0.296658654358591 0.383693627737994 no 1273 0.383363562872176 1762 2830968 YPR165W RHO1
SGTC_296 1222-0039 74.9 µM 0.296371428320041 0.383810654320848 no 1274 0.383473221304636 1742 5984176
SGTC_1268 0828-0275 2.46 µM 0.295565304108317 0.384139155916594 no 1275 0.383781036825306 1851 745337
SGTC_2065 5221596 34.26 µM 0.294960737924706 0.38438557576403 no 1276 0.384011936308018 1813 788581
SGTC_3088 9117578 49.47 µM 0.294645697296639 0.384514004158373 no 1277 0.384132274807769 1838 678341
SGTC_1397 3532-0190 20.1 µM 0.294387584371145 0.384619235046688 no 1278 0.384230876519644 1821 5322280
SGTC_489 paxilline 115 µM 0.294003065711431 0.38477601645988 no 1279 0.384377780375957 1758 105008 A toxic potassium channel blocker.
SGTC_347 4534-1311 26.2 µM 0.293894146730423 0.384820429880863 no 1280 0.38441939546784 1755 2862016
SGTC_2486 5283202 22.39 µM 0.293554739745558 0.384958838087352 no 1281 0.384549082534728 1720 1377751
SGTC_1887 st057648 70.8 µM 0.292694449795783 0.385309724989976 no 1282 0.384877856312238 1918 688672
SGTC_1506 4226-2149 212 µM 0.292476110983478 0.385398793906266 no 1283 0.384961311217816 1823 991114
SGTC_1565 sinapyl alcohol 95.1 µM 0.291583441036571 0.385763011621567 no 1284 0.385302568830204 1723 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2772 vinpocetine 57.06 µM 0.290571754476735 0.386175910999567 no 1285 0.3856894325254 1869 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_786 4544-0069 423 µM 0.289180643619828 0.386743875197781 no 1286 0.386221571758863 1855 748821 YLR208W SEC13
SGTC_553 k007-0256 45.7 µM 0.288171988322471 0.387155841872555 no 1287 0.386607544888317 1816 6287000
SGTC_2822 7994718 71.43 µM 0.286934674456107 0.387661373525487 no 1288 0.38708116996024 1830 1018011
SGTC_2750 bromebric acid 70.15 µM 0.285968715630407 0.388056169602583 no 1289 0.387451041351534 1802 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2044 5102272 200 µM 0.285494295929516 0.388250111610635 no 1290 0.387632736920092 1796 592666
SGTC_885 0865-0106 16.8 µM 0.283107420292494 0.389226284422917 no 1291 0.388547246811993 1737 2793380
SGTC_107 0358-0022 2.6945 µM 0.282911007808649 0.389306643481062 no 1292 0.388622528078189 1899 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2405 ticlatone 3.52 µM 0.282747356582139 0.389373602405177 no 1293 0.388685255756353 1572 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2293 7624732 200 µM 0.282480168354209 0.389482931200274 no 1294 0.388787675507698 1761 894453
SGTC_139 0099-0334 718.624 µM 0.2822659574141 0.389570588925069 no 1295 0.38886979335869 1940 97690
SGTC_474 dl-dihydrosphingosine 5 µM 0.281064091243202 0.390062511269208 no 1296 0.38933062122837 1884 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1277 0873-0036 22 µM 0.280897151175561 0.39013085358085 no 1297 0.389394642876781 1880 5965735
SGTC_1656 st012921 11 µM 0.280852594343966 0.390149094934029 no 1298 0.389411730964711 1896 6732821
SGTC_2241 6772625 37.8075 µM 0.280396824391937 0.390335698851242 no 1299 0.389586536571143 1779 2285411
SGTC_797 k781-0471 270 µM 0.279544220277527 0.390684844674535 no 1300 0.389913603564392 1863 23738129
SGTC_657 3534-0529 86.7 µM 0.277694984454641 0.391442418971994 no 1301 0.390623255528166 1913 1049549
SGTC_2566 crystal violet carbinol 226 nM 0.276879777910876 0.391776514694764 no 1302 0.390936210338572 1686 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_12 0849-0099 9.267 µM 0.275909997727672 0.392174063212107 no 1303 0.391308597397434 1926 6071388
SGTC_1006 4099-6547 255 µM 0.275682111083558 0.392267498668216 no 1304 0.391396118336064 1877 3146833
SGTC_205 1486-1330 71.903 µM 0.275547914333968 0.392322523379482 no 1305 0.391447659802237 1849 4118834
SGTC_685 1278-0033 54.9 µM 0.27519718979816 0.392466341171489 no 1306 0.391582372932693 1900 3590572
SGTC_3133 9127736 49.47 µM 0.274690786815193 0.392674022237018 no 1307 0.391776905019447 2005 27243420
SGTC_2113 5491891 107.031 µM 0.274134129703561 0.39290234829754 no 1308 0.391990773191786 1742 789979
SGTC_382 3229-0966 23.2 µM 0.273913718747291 0.392992765246249 no 1309 0.392075464306766 1916 5722370
SGTC_2197 6588183 93.1375 µM 0.273728554380411 0.393068727807097 no 1310 0.392146616159093 1875 884136
SGTC_814 3342-0569 96 µM 0.273543703842862 0.393144565682906 no 1311 0.392217651015602 1841 4346283
SGTC_148 3253-0744 288.01 µM 0.272914757451386 0.393402631309354 no 1312 0.392459371097472 1781 6893655
SGTC_678 1218-2179 85.9 µM 0.272081786073005 0.393744483360773 no 1313 0.392779567020489 1850 6820081 YOR116C RPO31
SGTC_3099 9120367 49.47 µM 0.271095607965076 0.394149317435303 no 1314 0.393158749738403 1822 24824940
SGTC_1788 fluconazole 20 µM 0.269134066827456 0.39495488555079 no 1315 0.393913257860817 1788 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1369 1866-0067 208 µM 0.269097560654506 0.394969882219454 no 1316 0.393927303769752 1930 3531355
SGTC_1427 4048-4900 550 nM 0.269047872732994 0.394990294176185 no 1317 0.39394642163553 1955 24132586
SGTC_821 1114-0266 29.2 µM 0.266920634209921 0.395864440141192 no 1318 0.394765134525958 1808 3123235
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.266860194637412 0.395889284246206 no 1319 0.394788402787919 1836 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2031 5180455 200 µM 0.26669432942672 0.395957466462921 no 1320 0.394852260150518 1821 29949
SGTC_3008 9078912 71.4286 µM 0.2666052628266 0.395994080386458 no 1321 0.394886551558116 1817 16648731
SGTC_1141 3253-0389 52.6 µM 0.266368834765401 0.396091276813494 no 1322 0.394977582345457 1948 5402031
SGTC_1854 st056233 32.9 µM 0.265234427812077 0.396557725353565 no 1323 0.395414437396301 1976 5393174
SGTC_1928 4'-methoxychalcone 40.3 µM 0.263073223973524 0.397446784308365 no 1324 0.396247070706979 2019 641818
SGTC_2626 ethyl orsellinate 100 µM 0.26270286383517 0.397599193761383 no 1325 0.396389804638554 1818 75653 A natural product.
SGTC_1795 st049545 62.3 µM 0.262304986734913 0.397762944326595 no 1326 0.396543158867848 1992 5291882
SGTC_2635 hydroquinidine 100 µM 0.261051072148672 0.398279123969265 no 1327 0.397026561211271 1820 442912 An experimental heart treatment.
SGTC_1794 st048918 76.9 µM 0.260688024829876 0.398428607327402 no 1328 0.397166550817914 1968 672303
SGTC_2742 clothiapine 36.27 µM 0.259923946811239 0.398743262228232 no 1329 0.3974612195383 1965 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2877 9040724 71.43 µM 0.259023964660946 0.399113968213997 no 1330 0.397808375105029 1997 6463895
SGTC_502 l-744,832 89.3 µM 0.258781686495794 0.399213779049587 no 1331 0.39790184436733 1964 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1707 st032323 6.317 µM 0.257262980217608 0.399839587196805 no 1332 0.398487884183811 1868 3132057 YMR211W DML1
SGTC_2522 biochanin a 4.94 µM 0.257222668326576 0.399856201894326 no 1333 0.398503442900179 1905 5280373 A possible chelator.
SGTC_2847 9005661 71.43 µM 0.254693094663613 0.400899136650522 no 1334 0.399480075033123 1931 2991449
SGTC_2175 5807670 165.306 µM 0.25461120646341 0.400932910730381 no 1335 0.399511701442535 1962 241186
SGTC_2499 avocadenofuran 51.48 µM 0.253916326189799 0.401219537865123 no 1336 0.399780100791393 1766 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1471 k673-0312 37 µM 0.253870972276815 0.401238247487738 no 1337 0.39979762050837 1969 24099884
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.252320401412789 0.40187803267007 no 1338 0.400396710067391 1948 140250 A respiratory chain inhibitor.
SGTC_3285 9112818 20.8695 µM 0.251442786446581 0.402240264409051 no 1339 0.400735895592856 1874 17017947 YPR165W RHO1
SGTC_2110 5483698 200 µM 0.251151617747069 0.40236046158251 no 1340 0.400848444644834 1866 2848765 YHR062C RPP1
SGTC_3064 1327-0027 10 µM 0.250473690060822 0.402640352250625 no 1341 0.401110524324915 1866 16000455 YPR107C YTH1
SGTC_2208 7283366 200 µM 0.250369158631232 0.402683513763905 no 1342 0.401150939034175 1959 898663
SGTC_2875 9039966 71.43 µM 0.249536968680775 0.40302717113175 no 1343 0.401472724121912 1963 6463691
SGTC_2325 6158266 200 µM 0.249091956689683 0.403210972015421 no 1344 0.401644825521653 1856 3623240
SGTC_361 000s-0510 1.45 µM 0.247999776198071 0.403662159957151 no 1345 0.402067289981395 1858 660
SGTC_3324 9138759 60.749 µM 0.245746769558937 0.404593298348959 no 1346 0.402939132621456 1898 45595710
SGTC_2002 4023503 131 µM 0.244586948017945 0.405072848645951 no 1347 0.403388135567059 2062 4736863 YCR052W RSC6
SGTC_2273 7815444 169.05 µM 0.244320490014242 0.405183040946637 no 1348 0.403491307752957 2005 2824616
SGTC_582 0987-0078 156 µM 0.244181152349016 0.405240666296236 no 1349 0.403545261787274 1965 1625765
SGTC_626 0214-0009 33 µM 0.243737050362718 0.405424345572572 no 1350 0.403717238258528 1949 3437874
SGTC_3226 9131256 49.47 µM 0.24269428911023 0.405855710369473 no 1351 0.404121115921368 1903 17178073
SGTC_854 0422-0053 192 µM 0.242253376956293 0.406038139354536 no 1352 0.404291918834583 1930 3596728
SGTC_1084 voriconazole 435 nM 0.242145697053291 0.406082695402109 no 1353 0.404333635225685 2012 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_698 k064-0052 127 µM 0.241901618513383 0.406183695306326 no 1354 0.40442819799101 1920 5088751
SGTC_3079 9117512 49.47 µM 0.240845111328776 0.406620950783896 no 1355 0.404837582367188 1920 7185044
SGTC_699 0375-0592 111 µM 0.240604194337774 0.406720675160925 no 1356 0.404930949531516 2052 762578
SGTC_1201 1889-3372 45.9 µM 0.240150617751869 0.406908443553193 no 1357 0.405106747414458 1873 5392199
SGTC_2356 9061756 188.97 µM 0.240128374440004 0.406917652231229 no 1358 0.40511536900298 2002 20104043
SGTC_2277 7947813 106.88 µM 0.240061523337422 0.406945328737914 no 1359 0.405141281010477 1971 1246798
SGTC_566 0958-0068 16.5 µM 0.240019814539818 0.406962596509263 no 1360 0.405157447875612 1935 6815365
SGTC_723 4182-0001 115 µM 0.239891144700755 0.40701586797746 no 1361 0.405207322975924 1842 744821 YLR208W SEC13
SGTC_2690 usnic acid 100 µM 0.238983711138998 0.407391609460762 no 1362 0.405559106728232 1988 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2202 7226349 200 µM 0.234166030823397 0.409387888213241 no 1363 0.407428042698264 1899 844334
SGTC_1600 coumarin 106 71.1 µM 0.233970867886242 0.409468806844256 no 1364 0.407503797530225 1918 100336 A hepatotoxic, DNA x-linker.
SGTC_1321 1326-2144 215 µM 0.233434034294381 0.409691409153325 no 1365 0.407712193756015 1996 3513030
SGTC_186 3455-3465 67.277 µM 0.233116620305913 0.409823041083467 no 1366 0.407835424634017 1916 755278
SGTC_902 1120-0002 2.07 µM 0.231323293975326 0.410566926001583 no 1367 0.408531825704721 1861 3280475
SGTC_1076 itraconazole 331 nM 0.23111854937951 0.410651876081514 no 1368 0.408611352438267 1994 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2493 resveratrol 26.09 µM 0.231051412078281 0.410679732767857 no 1369 0.408637430675057 1881 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2696 st077691 74.316 µM 0.230712632095471 0.410820306618617 no 1370 0.408769029631175 1911 757133
SGTC_2676 harmalol 100 µM 0.229637113159378 0.411266659808657 no 1371 0.409186882649752 1980 5459187 A monoamine oxidase inhibitor
SGTC_1553 gossypol 38.6 µM 0.229302216497708 0.411405669402342 no 1372 0.409317015429314 1965 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1740 st038286 13.222 µM 0.229286088237601 0.411412364234515 no 1373 0.409323282735218 1932 716786
SGTC_2543 pimpinellin 60.67 µM 0.22892092402684 0.411563950603786 no 1374 0.40946518866875 1846 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2830 7992007 71.43 µM 0.228547182781232 0.411719111127732 no 1375 0.409610439995363 1824 1952075
SGTC_975 1335-0046 28.5 µM 0.228294226484541 0.411824135018995 no 1376 0.409708756330387 1807 16486740
SGTC_1081 sertraline 6 µM 0.227785706568242 0.41203528443147 no 1377 0.409906419560564 2002 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_836 0330-0104 1.35 µM 0.226277601833686 0.412661634480633 no 1378 0.41049275889424 1949 46494820
SGTC_865 0488-0499 301 µM 0.225688176457927 0.412906496738313 no 1379 0.410721977335966 2047 9634651
SGTC_1170 0310-0127 64.8 µM 0.223590420740823 0.413778232000055 no 1380 0.411538009059877 1938 774975
SGTC_1787 fluconazole 80 µM 0.223530693774058 0.413803058151561 no 1381 0.411561248606615 1934 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.221735523936548 0.414549400023709 no 1382 0.412259887149207 2003 16623 A steroid.
SGTC_1964 st076914 61 µM 0.220729108196015 0.414967952553413 no 1383 0.412651682674316 2000 24208661
SGTC_1629 st005085 44.9 µM 0.220318596751824 0.415138705574119 no 1384 0.41281151892893 1854 24207091
SGTC_791 1348-1292 225 µM 0.219127311313 0.415634313681207 no 1385 0.413275438187812 1990 5437054
SGTC_2856 9022925 19.48 µM 0.21908669741407 0.415651212571245 no 1386 0.413291256493753 1930 4944862
SGTC_1752 st044819 83.042 µM 0.218729093925013 0.415800013241468 no 1387 0.413430542013946 1875 441209 YML126C ERG13
SGTC_2470 5664817 21.68 µM 0.217761469223737 0.416202707381152 no 1388 0.413807483601392 1946 2859561
SGTC_2720 fluspirilene 36.88 µM 0.216776214518959 0.416612828960964 no 1389 0.41419137463463 1988 3396 An atypical antipsychotic.
SGTC_2007 4011539 71.82 µM 0.21655127772503 0.416706473771954 no 1390 0.414279029693132 1897 45595301
SGTC_1959 st077091 55.8 µM 0.215672536331272 0.417072353226092 no 1391 0.414621505119497 1896 821356 YKL052C ASK1
SGTC_1052 3253-3998 198 µM 0.21458116082327 0.417526866612755 no 1392 0.415046941641573 1994 5450317
SGTC_3227 9130768 49.47 µM 0.214152096326358 0.417705584690775 no 1393 0.415214225510589 1968 17720899
SGTC_2871 9038510 12.99 µM 0.213056395296012 0.418162053688631 no 1394 0.415641487626678 2050 4945164
SGTC_1896 st058441 89 µM 0.212993526351173 0.418188248238482 no 1395 0.415666006029439 1876 688759
SGTC_2030 5175110 200 µM 0.212796108669513 0.418270505314412 no 1396 0.415742999533797 1989 2831986
SGTC_1258 0671-0043 57.1 µM 0.212705274881047 0.418308353793157 no 1397 0.415778426077954 1889 4298767
SGTC_2366 9070441 60.58 µM 0.212390469757196 0.418439532143738 no 1398 0.415901210107756 1898 6837235
SGTC_667 1498-1044 59 µM 0.211717850409211 0.41871984098746 no 1399 0.416163580582377 1926 6739982
SGTC_1761 st044296 37 µM 0.207824577980715 0.420343138304419 no 1400 0.417682970565045 1933 1826700
SGTC_2880 9042983 58.44 µM 0.20774852385439 0.420374862611785 no 1401 0.417712663796316 1927 6464714
SGTC_1753 st043925 64 µM 0.207662688508627 0.420410667561184 no 1402 0.417746176397874 2051 670181
SGTC_66 0109-0187 42.4 µM 0.207125724296426 0.420634669203008 no 1403 0.417955836304406 1818 759417
SGTC_1072 oxiconazole 14.9 nM 0.206718417926535 0.420804599526575 no 1404 0.418114886324139 1971 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2479 5617353 43.85 µM 0.205440541830752 0.421337831679209 no 1405 0.418613973960456 2005 2731746
SGTC_353 1988-1175 58.3 µM 0.204419815231824 0.421763864204081 no 1406 0.419012723396878 1872 2788357
SGTC_1166 k206-0078 225 µM 0.201957950333876 0.42279177727081 no 1407 0.419974798766083 1921 5404595
SGTC_411 enrofloxacin 100 µM 0.201454673259146 0.423001977692031 no 1408 0.420171534150875 2092 71188 A bacterial gyrase inhibitor.
SGTC_938 3126-1755 342 µM 0.200331956051685 0.42347097450843 no 1409 0.420610485883541 2077 1777771
SGTC_166 k072-0058 166.424 µM 0.199018404099799 0.424019827049224 no 1410 0.421124174085079 2100 5846229
SGTC_570 0987-0065 62.6 µM 0.197697550577745 0.424571879108366 no 1411 0.421640853124183 2071 3104428
SGTC_1499 4480-0877 67.3 µM 0.194870508459666 0.425753940226636 no 1412 0.422747161199699 2058 2861909
SGTC_88 0180-0332 8.668 µM 0.194619075387721 0.425859103528278 no 1413 0.42284558430002 1978 3101745
SGTC_45 0kpi-0036 14.9 µM 0.194091920842005 0.426079606002704 no 1414 0.423051953786738 1977 2795021
SGTC_1018 4259-0013 28.1 µM 0.194068559898235 0.426089378142868 no 1415 0.423061099574827 1955 6801262
SGTC_1635 st007035 42.4 µM 0.194047010573553 0.426098392503051 no 1416 0.423069536152468 2025 3716403
SGTC_971 1315-0384 26.7 µM 0.193204224023519 0.426450971217374 no 1417 0.423399515385279 1893 6769120
SGTC_1023 4482-3888 16 µM 0.192925843457992 0.42656744431348 no 1418 0.423508522540941 2061 3303168
SGTC_1852 st056254 31.4 µM 0.191979350212625 0.426963500400236 no 1419 0.423879190348479 1983 442583
SGTC_3119 9125183 49.47 µM 0.191448614798814 0.427185616633878 no 1420 0.424087067637282 2071 22695334
SGTC_3120 9124077 49.47 µM 0.19026004954415 0.427683122586318 no 1421 0.424552678819247 2095 18774327 YGL155W CDC43
SGTC_1971 st069429 63.5 µM 0.189535612898977 0.427986411488305 no 1422 0.424836522925052 2076 1246522 YGL099W LSG1
SGTC_1737 st035557 69.7 µM 0.188398848982021 0.428462408897647 no 1423 0.425282000960737 1916 5716916
SGTC_2551 apiole 73.87 µM 0.188036228975602 0.428614270785143 no 1424 0.425424125542911 2045 10659 A possible DNA adduct former.
SGTC_1160 4092-0570 10.5 µM 0.187619774385002 0.428788691135272 no 1425 0.425587361902646 1890 4994975
SGTC_2652 actinonin 100 µM 0.187435653686047 0.428865809372955 no 1426 0.42565953516565 2024 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1448 4255-0083 152 µM 0.187260889642053 0.428939011124419 no 1427 0.425728043028321 2058 5399660
SGTC_1625 st003711 30.1 µM 0.18625177559241 0.429361736847265 no 1428 0.42612366158577 2036 24207034 YER133W GLC7
SGTC_2270 7924575 90.91 µM 0.186047634018851 0.429447263208156 no 1429 0.426203703413928 2104 1262135
SGTC_59 0330-0160 1.33 µM 0.185964209121823 0.429482215532494 no 1430 0.426236414340087 2007 4293482
SGTC_214 4373-3496 70 µM 0.184811835463183 0.429965079136521 no 1431 0.426688312208328 2045 3779166
SGTC_254 nsc-64875 3.808 µM 0.18410530547824 0.430261178730272 no 1432 0.426965422227193 2078 56993
SGTC_277 nystatin 15.5 µM 0.183190391067299 0.430644668391444 no 1433 0.427324316804183 1972 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3038 9091290 49.47 µM 0.181961694897303 0.431159783654463 no 1434 0.4278063935196 2060 25236843
SGTC_1930 st074634 34.3 µM 0.181859525104834 0.431202622328441 no 1435 0.427846484516493 1902 684253 YOR116C RPO31
SGTC_850 0388-0143 75.9 µM 0.18144122645093 0.431378018803006 no 1436 0.428010630912901 1970 67273
SGTC_176 1486-1328 72.834 µM 0.180719594276064 0.431680637604328 no 1437 0.428293839007571 1944 22310231
SGTC_1051 3253-3903 78 µM 0.180698436352498 0.431689510854382 no 1438 0.428302143096742 2044 5509239
SGTC_805 3852-0218 479 µM 0.17988517696057 0.432030603200822 no 1439 0.428621356222741 1917 6615355
SGTC_257 daunorubicin 18.5 µM 0.179319253723685 0.432267989224898 no 1440 0.428843514796063 2086 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_861 0443-0273 110 µM 0.177584103547588 0.432995979232828 no 1441 0.429524804816606 2036 6149169
SGTC_2239 6685329 187.64 µM 0.177486715170169 0.433036845725875 no 1442 0.429563049667375 1951 805680
SGTC_2226 7298446 200 µM 0.176384179491926 0.433499545915135 no 1443 0.42999606637348 2094 3283010
SGTC_350 k064-0020 19.8 µM 0.175153710808989 0.434016043249564 no 1444 0.430479427700695 2106 2790705
SGTC_444 curcumin 90.4 µM 0.1723341286582 0.435200004949119 no 1445 0.431587427460135 2049 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3023 9089636 49.47 µM 0.172064948771395 0.435313065969764 no 1446 0.431693234282779 2148 17249241
SGTC_757 1066-0008 322 µM 0.171938293999664 0.43536626537687 no 1447 0.431743020303665 2073 6842497
SGTC_2290 7904846 200 µM 0.171808162294404 0.43542092643537 no 1448 0.431794174182282 1952 2962154
SGTC_1809 st050081 57.6 µM 0.171261870583521 0.43565040651088 no 1449 0.432008930166379 2076 5036894
SGTC_959 1222-0044 107 µM 0.170714233935451 0.435880473302173 no 1450 0.432224235034227 2147 6083612
SGTC_1468 k284-1086 134 µM 0.169996298116879 0.436182117075829 no 1451 0.432506523976253 1978 15996457
SGTC_717 1532-0246 73.2 µM 0.169865217123557 0.436237195322837 no 1452 0.432558068121857 1985 9561992
SGTC_2643 anethole 100 µM 0.169770741378679 0.436276893365948 no 1453 0.432595218930095 2020 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2045 5106652 78.05 µM 0.169560942133276 0.436365051827257 no 1454 0.432677720664425 2095 673349
SGTC_1859 st055998 20 µM 0.168018976883051 0.437013088357744 no 1455 0.433284174957454 2143 676301
SGTC_2763 lisinopril 49.32 µM 0.166154599631545 0.437796849499364 no 1456 0.434017643486532 2146 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1654 st012436 41.8 µM 0.166143536056177 0.43780150122123 no 1457 0.434021996711422 2097 4323132
SGTC_2385 9074692 200 µM 0.166029941108971 0.437849263141032 no 1458 0.434066693787635 1963 17046906
SGTC_604 1000-0114 314 µM 0.165716871700258 0.437980900405703 no 1459 0.434189883973579 2101 1572745
SGTC_2477 5967686 25.23 µM 0.164494059202181 0.438495125791209 no 1460 0.43467111155943 1996 776118
SGTC_2189 6047310 154.431 µM 0.164478223733758 0.438501785712537 no 1461 0.434677344111447 2017 711535
SGTC_688 0527-0193 473 µM 0.163101762679075 0.439080750139212 no 1462 0.435219155982719 2031 4007154
SGTC_2884 9058502 51.95 µM 0.16120090627577 0.439880498796334 no 1463 0.435967583674293 2021 6471554
SGTC_508 roscovitine 141 µM 0.161162178468083 0.439896795335839 no 1464 0.435982834438425 2056 160355 A CDKinase inhibitor.
SGTC_2820 7989630 71.43 µM 0.160621749562428 0.440124216730544 no 1465 0.436195661823175 2148 2984098
SGTC_909 3448-9333 149 µM 0.159927264285523 0.440416496582564 no 1466 0.436469185571932 1995 3344074
SGTC_304 1310-0298 97 µM 0.159799766679664 0.440470158532816 no 1467 0.436519403941187 2025 1550234
SGTC_1968 st069590 43.6 µM 0.158408506728367 0.441055791140656 no 1468 0.437067455506806 2114 6384066
SGTC_2665 lovastatin 100 µM 0.157725599627762 0.441343299168461 no 1469 0.437336513699208 2029 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2802 7925815 54.55 µM 0.156945253059171 0.44167186763837 no 1470 0.437643997487104 2024 1262923
SGTC_1107 amlodipine 47 µM 0.156571669737037 0.441829180816807 no 1471 0.437791215698579 2076 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2115 tiliquinol 12.7705 µM 0.156152808311438 0.442005571180309 no 1472 0.437956286919629 2072 71208 A bioactive hydroxyquinoline.
SGTC_1774 st048371 48.465 µM 0.155160263472543 0.442423596185892 no 1473 0.438347486997582 1973 4242727
SGTC_2131 toluylene red 5.2905 µM 0.155053282380855 0.442468656698066 no 1474 0.438389655962267 1993 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2881 9058953 51.95 µM 0.154719992244098 0.442609043510322 no 1475 0.438521034127137 2121 17122249
SGTC_2583 asiatic acid 100 µM 0.154718391387495 0.442609717832576 no 1476 0.438521665178081 2056 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_880 0833-0487 87.2 µM 0.154600342778439 0.442659443421475 no 1477 0.438568199874184 2009 76075
SGTC_90 0870-0863 4.608 µM 0.153984972805423 0.442918670185881 no 1478 0.438810792113977 2000 1738164
SGTC_2103 5378138 10 µM 0.153867654296846 0.442968093796865 no 1479 0.438857044235923 2097 244142
SGTC_2190 6049624 200 µM 0.153793905490832 0.442999162940536 no 1480 0.438886119690055 2104 2265554
SGTC_3187 9109394 49.47 µM 0.151852446144813 0.443817192916773 no 1481 0.43965165784832 1990 17098090
SGTC_724 3910-0327 137 µM 0.151258794456309 0.444067374820868 no 1482 0.43988578624387 2015 2885483
SGTC_3131 9127911 49.47 µM 0.15010350009205 0.444554312920659 no 1483 0.440341479299701 2065 45595681
SGTC_741 4582-0002 126 µM 0.149218323556221 0.444927457342971 no 1484 0.440690680877138 2015 2912688
SGTC_1645 Cervolide 78 µM 0.148556098897643 0.445206648774247 no 1485 0.440951958259295 2050 23173 A fragrance.
SGTC_1389 3405-0187 19 µM 0.148500374457123 0.445230143230975 no 1486 0.440973945228903 1990 799890
SGTC_2253 7938677 135.83 µM 0.147625985849381 0.445598826810756 no 1487 0.441318973028076 2163 2301972
SGTC_859 0439-0102 54.6 µM 0.145747001022281 0.446391254437961 no 1488 0.442060558025153 2169 610143
SGTC_638 3970-0837 4.09 µM 0.144342309195043 0.446983797689459 no 1489 0.442615085097168 2024 4118451 YLR208W SEC13
SGTC_2555 cholic acid 100 µM 0.142981014102096 0.447558147789741 no 1490 0.443152587835463 2060 6708657 Influences liver metabolism.
SGTC_1458 k015-0034 6.33 µM 0.140516514827128 0.448598234677064 no 1491 0.444125952499007 1977 3598957
SGTC_549 1661-1316 519 µM 0.140465988891823 0.448619561740955 no 1492 0.444145911482565 2175 2857282
SGTC_2024 5144227 134 µM 0.139732784821691 0.44892906482554 no 1493 0.444435560988808 2119 3475211
SGTC_621 3584-0052 32.1 µM 0.139645838612175 0.448965768978202 no 1494 0.444469910732624 2157 2273927
SGTC_2376 9072922 81.32 µM 0.139128900345998 0.449184002346735 no 1495 0.444674145570147 2095 17087968
SGTC_1772 st048439 82.2 µM 0.13768347562889 0.449794291806576 no 1496 0.445245289774162 2022 2927068 YDL195W SEC31
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.136702269192348 0.450208646070088 no 1497 0.445633067908574 2093 65057 A dermal irritant. YDR527W RBA50
SGTC_2889 9059656 51.95 µM 0.136696801878645 0.450210955017812 no 1498 0.445635228766832 2102 3949838
SGTC_2916 7875993 68.79 µM 0.135999847164017 0.450505305661719 no 1499 0.4459107008938 2202 1299250
SGTC_1681 tripelennamine 100 µM 0.135869706395858 0.45056027210916 no 1500 0.445962142074414 2193 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1977 st070720 65.3 µM 0.134219094594748 0.451257508884311 no 1501 0.446614663612369 2025 682188
SGTC_1806 st050005 60.3 µM 0.132926120198731 0.451803780809593 no 1502 0.447125904638414 2026 5194765
SGTC_2620 irigenin 100 µM 0.132660169863956 0.451916154170096 no 1503 0.447231072108649 2117 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2070 5230947 200 µM 0.132231263434788 0.452097390318622 no 1504 0.447400686793811 2183 2835538
SGTC_2078 5212016 200 µM 0.131271987040143 0.452502772519142 no 1505 0.4477800755527 2209 1899708
SGTC_1474 0330-0125 5.35 µM 0.130029865776041 0.453027756109953 no 1506 0.448271398902792 2160 X1474
SGTC_2783 7738165 71.43 µM 0.129682874407471 0.45317442701432 no 1507 0.448408666190277 2019 17201110
SGTC_2106 5357045 167.29 µM 0.129116801016831 0.453413716109981 no 1508 0.448632613999442 2146 668842
SGTC_1868 st057644 42.7 µM 0.129113897139015 0.453414943673466 no 1509 0.448633762862837 2168 688665
SGTC_1522 st012842 45.6 µM 0.128521978236885 0.453665176298119 no 1510 0.448867953168702 2019 3491067 YOR116C RPO31
SGTC_1683 st010134 710 nM 0.127608266991488 0.454051482123856 no 1511 0.44922949425574 2064 3818134
SGTC_1862 st057513 3.81 µM 0.126603986167563 0.454476129784939 no 1512 0.449626920913381 2124 5393163
SGTC_1118 chelidonine 707.474 nM 0.126585224155089 0.454484063565324 no 1513 0.449634346135374 2200 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2768 sulfasalazine 50.2 µM 0.126311949068634 0.454599623829118 no 1514 0.449742499014295 2185 5384001 An antioxidant and salicylic acid derivative.
SGTC_2411 st077133 39.94 µM 0.124950300834594 0.45517548323389 no 1515 0.450281448033664 2183 1403142 YNL221C POP1
SGTC_92 0063-0024 660.874 µM 0.124880878900339 0.455204845240327 no 1516 0.450308928141388 2208 3594437
SGTC_2713 st079149 53.4 µM 0.123368594176371 0.455844526504283 no 1517 0.450907612640314 2097 3103253
SGTC_2389 9091542 195.52 µM 0.123050593054939 0.455979052410276 no 1518 0.451033517440835 2049 3626624 YOL127W RPL25
SGTC_2828 7998861 71.43 µM 0.122134799345761 0.456366494211203 no 1519 0.45139613114029 2198 2988188
SGTC_1861 st057647 17.4 µM 0.121276135270367 0.456729804062451 no 1520 0.451736160887953 2171 688668
SGTC_1922 5578187 25 µM 0.121113060394553 0.456798806863519 no 1521 0.451800742314621 2176 1350412
SGTC_2549 cedrol 20.94 µM 0.119205407330198 0.457606099172038 no 1522 0.452556311384286 2209 6708665 A sedative which affects the nervous system.
SGTC_518 1021-0119 62.6 µM 0.119004349206985 0.457691194428896 no 1523 0.452635955050709 2003 1097762
SGTC_2181 6316240 54.2555 µM 0.118743401189932 0.457801640202323 no 1524 0.452739325298737 2082 12779990
SGTC_1359 1582-0056 520 nM 0.118126592067032 0.458062716480635 no 1525 0.452983676768768 2144 3661189
SGTC_1198 1612-1005 86.7 µM 0.116492558593918 0.458754439620553 no 1526 0.453631091664281 2183 6998509
SGTC_1663 st014140 55.4 µM 0.116163013517126 0.458893958670599 no 1527 0.453761674598169 2223 4207120
SGTC_232 clozapine 119 µM 0.114664646562273 0.459528383842631 no 1528 0.454355468501862 2192 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3115 9123671 49.47 µM 0.114078228370596 0.459776707955977 no 1529 0.454587890392081 2222 3286988
SGTC_1996 st072960 66.8 µM 0.113825083969948 0.459883909107947 no 1530 0.454688226843579 2227 1719405
SGTC_117 lucigenin 22.078 µM 0.113080660414847 0.460199173173879 no 1531 0.454983303694566 1971 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_914 3820-6779 408 µM 0.112946120670999 0.460256153555817 no 1532 0.455036635618582 2171 2893481
SGTC_209 4077-0173 175.592 µM 0.112782925571122 0.460325271172834 no 1533 0.45510132769207 2144 15993494
SGTC_2351 9026858 72.31 µM 0.111892411670839 0.460702449386964 no 1534 0.45545435671462 2158 1409300
SGTC_2745 rifampicin 24.3 µM 0.111745518784925 0.4607646694486 no 1535 0.455512593277131 2220 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1133 3473-0247 50 µM 0.109269867840412 0.461813435050292 no 1536 0.456494222719992 1974 711311
SGTC_593 1203-0218 61.7 µM 0.108267651828882 0.462238082015886 no 1537 0.456891690924669 2219 3666956
SGTC_204 PMA1.184 62.41 µM 0.107667978011523 0.462492189238765 no 1538 0.457129535828605 2228 2252213 YGL008C PMA1
SGTC_3165 9101544 49.47 µM 0.107223029987404 0.462680742481521 no 1539 0.457306022730976 2181 5002184
SGTC_3233 9132340 49.47 µM 0.106307708730316 0.463068649593856 no 1540 0.457669107784676 2106 17682950
SGTC_2272 7805186 180 µM 0.105632441728038 0.463354845828681 no 1541 0.457936991982961 2227 2956062 YPR165W RHO1
SGTC_2159 5658611 73.75 µM 0.105320747594706 0.463486956554534 no 1542 0.458060650166128 2227 793844
SGTC_2335 9018011 154.17 µM 0.104943661926355 0.463646788688963 no 1543 0.45821025650987 2177 6458208
SGTC_1307 1187-1599 12.2 µM 0.104800793177055 0.463707346799651 no 1544 0.458266940326309 2128 1538471
SGTC_868 0527-0199 213 µM 0.104316289898551 0.463912720589807 no 1545 0.458459175485665 2101 2849450
SGTC_1875 nocodazole 6 µM 0.104311614403406 0.463914702510141 no 1546 0.458461030617637 2251 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1105 epirubicin 18.1 µM 0.103269847983894 0.464356324618629 no 1547 0.458874402734136 2081 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3030 9087619 49.47 µM 0.102783381651682 0.464562560860775 no 1548 0.459067447461587 2180 25236973
SGTC_2278 7948257 134.34 µM 0.100219306073628 0.465649750639799 no 1549 0.460085109573633 2250 1247028
SGTC_640 3381-0960 37.1 µM 0.0993121605986288 0.466034449837573 no 1550 0.460445211694654 2211 1745025
SGTC_423 5-fluorouracil 457 µM 0.096965091470221 0.467029933425268 no 1551 0.461377058373873 2148 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1984 st072354 53.1 µM 0.0963097534926521 0.467307924933203 no 1552 0.461637282465897 2138 5762938
SGTC_2306 7482397 179.52 µM 0.0958446836616086 0.467505215205988 no 1553 0.4618219641304 2214 891448
SGTC_907 3448-6986 75.5 µM 0.0956795534668763 0.467575268073876 no 1554 0.46188754017764 2225 590582
SGTC_869 0564-0080 44.1 µM 0.0956729824170911 0.467578055718597 no 1555 0.461890149676244 2068 6843321
SGTC_2906 7926292 26.41 µM 0.0951933655333343 0.467781528477487 no 1556 0.462080619797471 2126 2966319
SGTC_3331 9141060 1.957 µM 0.094711614576163 0.467985915070256 no 1557 0.462271946177119 2110 4906567 YPR165W RHO1
SGTC_3215 9129942 49.47 µM 0.0941163800398461 0.468238459604441 no 1558 0.462508354373662 2244 17682944
SGTC_1232 0279-0259 161 µM 0.0934005820013656 0.468542173421686 no 1559 0.46279266408512 2146 1560000
SGTC_2279 7948423 32.93 µM 0.0922455523912889 0.469032292162762 no 1560 0.463251473364254 2262 1247112
SGTC_1925 st057770 10.1 µM 0.0917358972618266 0.469248571309246 no 1561 0.463453937869729 2021 5989122
SGTC_2524 avocatin b 10.57 µM 0.0912769490867233 0.469443340030798 no 1562 0.463636266740876 2217 6710748
SGTC_414 piperonyl butoxide 100 µM 0.0907561222925714 0.469664377695315 no 1563 0.463843187722341 2129 5794 A potent inhibitor of cytochrome P450.
SGTC_1826 st055655 41.6 µM 0.0900777453687841 0.469952293272162 no 1564 0.464112716968646 2109 676168
SGTC_3123 9126162 49.47 µM 0.0896254178086719 0.47014427810305 no 1565 0.464292442599121 2245 25239884
SGTC_8 0354-0001 70 µM 0.0887392114236562 0.470520437505586 no 1566 0.46464458461745 2186 4993152
SGTC_2872 9044037 25.97 µM 0.0884137355783373 0.47065859569378 no 1567 0.464773922318003 2167 6465195
SGTC_540 1187-0821 17.3 µM 0.0879034247265856 0.470875219863337 no 1568 0.464976717302814 2071 847520
SGTC_379 3970-0972 5.9 µM 0.0869773771183563 0.471268343981004 no 1569 0.465344747195715 2148 2898042 YBL034C STU1
SGTC_2610 ononetin 44.17 µM 0.0869128820691529 0.471295724354254 no 1570 0.465370379929628 2170 259632
SGTC_2135 5326629 150.42 µM 0.0857940696296582 0.471770720309657 no 1571 0.465815060423729 2171 5020077
SGTC_184 1494-0393 24.714 µM 0.0850045522833911 0.472105937022969 no 1572 0.466128885806223 2207 3090647
SGTC_2143 5623677 140.463 µM 0.0848089256253768 0.472189000105223 no 1573 0.466206648742856 2249 5375313
SGTC_1349 flufenamic acid 69 µM 0.0845430072426245 0.472301910993847 no 1574 0.466312355189832 2228 3371 A non-steroidal anti-inflammatory.
SGTC_2311 7694451 200 µM 0.0831817321558882 0.472879953012327 no 1575 0.466853519011049 2201 2163142
SGTC_1680 diphenhydramine 100 µM 0.0826641619903703 0.473099745320946 no 1576 0.46705929094724 2101 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1886 st057356 49.9 µM 0.0819943728637793 0.473384191364421 no 1577 0.467325594096971 2113 24207747
SGTC_2431 5490079 200 µM 0.0816525532817871 0.473529360542555 no 1578 0.467461504651522 2206 5722345
SGTC_432 NS 1619 61.3 µM 0.0815995294292996 0.473551879840211 no 1579 0.467482587754662 2131 4552 A K+/calcium channel activator.
SGTC_2215 7188065 200 µM 0.0807458028676638 0.473914470183843 no 1580 0.467822055145842 2248 940217
SGTC_2396 5342950 42.78 µM 0.0783853383813991 0.474917106054067 no 1581 0.468760767960702 2178 1886677
SGTC_2981 9013952 38.96 µM 0.0776363949899073 0.475235262330544 no 1582 0.469058645362289 2057 2996344
SGTC_2345 9052315 157.45 µM 0.075051737846319 0.476333362386716 no 1583 0.470086773542262 2195 6469265
SGTC_3230 9131665 49.47 µM 0.0741380117463022 0.476721605350224 no 1584 0.470450284735451 2233 15943720
SGTC_3087 9117406 49.47 µM 0.0738083808868877 0.476861671213804 no 1585 0.470581429117055 2157 42546093
SGTC_2832 7992762 51.95 µM 0.0730311828007714 0.477191927431778 no 1586 0.470890651735191 2144 2985177
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0708997703683944 0.478097712167297 no 1587 0.471738763068378 2274 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2056 5235370 200 µM 0.0705056723481788 0.478265204239717 no 1588 0.47189559295349 2218 5511916
SGTC_1828 st055811 49 µM 0.0704670578777199 0.47828161563718 no 1589 0.471910959677477 2291 5877589
SGTC_3344 9148862 3.898 µM 0.0697828635428365 0.478572408696557 no 1590 0.472183243417634 2253 4905352
SGTC_616 4092-0450 108 µM 0.0695254852447083 0.478681801371688 no 1591 0.472285673720146 2216 787165
SGTC_341 1486-1430 230 µM 0.0681986971600411 0.47924574716663 no 1592 0.472813732037172 2292 2054753 YPL210C SRP72
SGTC_2712 st079126 47.7 µM 0.0662397158326119 0.480078479725551 no 1593 0.473593488764481 2274 3152970
SGTC_1746 st038117 42 µM 0.0659479736249305 0.480202502337235 no 1594 0.473709623128005 2212 2898218
SGTC_3109 9122853 49.47 µM 0.0657854866583197 0.480271578048879 no 1595 0.473774305586603 2204 1234709
SGTC_1020 4335-0961 93.3 µM 0.0651017800373516 0.480562238728535 no 1596 0.474046481588198 2115 669075
SGTC_3128 9127691 49.47 µM 0.0630207610650991 0.481446994575662 no 1597 0.474874986120336 2229 41316314
SGTC_3341 9147222 25.867 µM 0.0627125730176786 0.481578030173127 no 1598 0.474997692641089 2224 1939759
SGTC_891 0929-0073 133 µM 0.0624758016411293 0.481678702135983 no 1599 0.475091965889931 2276 5603632
SGTC_343 4130-2827 29.8 µM 0.0620406339052229 0.481863732569612 no 1600 0.47526523656588 2208 1118244
SGTC_1196 1588-0294 184 µM 0.0615479322345942 0.482073230764121 no 1601 0.475461421165409 2200 6144269
SGTC_168 3970-0862 530.542 µM 0.061478151975881 0.482102901936198 no 1602 0.475489206842704 2232 3135186
SGTC_810 3825-7150 143 µM 0.0609734824784763 0.482317494730701 no 1603 0.47569016383376 2308 22330411 YGL099W LSG1
SGTC_1491 4138-0063 26.5 µM 0.0600704650898682 0.482701483573675 no 1604 0.476049756456788 2311 23883227
SGTC_398 bronopol 33.3 µM 0.0593725186866646 0.482998281376209 no 1605 0.476327700672833 2195 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_116 0155-0182 31.788 µM 0.0593442953814914 0.483010283378115 no 1606 0.476338940324098 2154 771486
SGTC_429 1112-0049 25.5 µM 0.0593201976698411 0.48302053097751 no 1607 0.476348537013574 2145 2836170
SGTC_2597 laccaic acid a 100 µM 0.0591837681414276 0.483078548114802 no 1608 0.476402869062542 2246 5491415 A textile dye.
SGTC_3018 9082602 49.47 µM 0.0587025095694011 0.483283207869935 no 1609 0.476594530219962 2231 17332089
SGTC_1773 st048542 73.5835 µM 0.0578969179892572 0.483625803131902 no 1610 0.476915369047205 2247 3237138
SGTC_561 1550-0330 72.9 µM 0.0575158173825989 0.483787878644206 no 1611 0.477067153258262 2261 6812934
SGTC_367 0335-0881 7.1 µM 0.0568246564680686 0.484081824271559 no 1612 0.477342436323824 2268 23828853
SGTC_2101 5377231 179.231 µM 0.0554255748706484 0.484676869645951 no 1613 0.477899710674743 2250 2844213
SGTC_1759 st043059 70 µM 0.0553580062417132 0.484705608229632 no 1614 0.4779266253355 2270 669426
SGTC_440 fluspirilene 35.1 µM 0.0546358434436268 0.485012766589664 no 1615 0.478214291227607 2272 3396 An atypical antipsychotic.
SGTC_579 4491-1009 110 µM 0.0545848955956992 0.485034436636249 no 1616 0.478234586192903 2326 1271041
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.0543749642336617 0.485123728849751 no 1617 0.478318212492863 2274 7104
SGTC_1747 st037496 66.6 µM 0.0536586317323974 0.485428419331257 no 1618 0.478603571192652 2290 723305
SGTC_3337 9144342 33.5465 µM 0.0535051968757855 0.485493683628312 no 1619 0.478664695037235 2298 17682949
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0534831056198605 0.485503080288478 no 1620 0.478673495572326 2263 6708760
SGTC_904 1141-0088 396 µM 0.0533165405403443 0.485573930093047 no 1621 0.478739850750172 2162 1378119
SGTC_362 0310-0100 9.03 µM 0.0517604676748842 0.486235839978833 no 1622 0.479359777763903 2268 790235
SGTC_69 0096-0274 206.684 µM 0.0504599195044099 0.486789085973774 no 1623 0.479877944147597 2268 6741392
SGTC_1221 2958-7315 257 µM 0.0502052060719791 0.486897442669387 no 1624 0.479979431471142 2275 4562705
SGTC_1193 1488-0126 41.5 µM 0.0497749419534202 0.487080481923505 no 1625 0.480150867674391 2322 1384710
SGTC_3138 9097216 49.47 µM 0.0495598596310388 0.487171981414616 no 1626 0.480236567337039 2350 25237486
SGTC_1424 4048-1941 275 µM 0.0483768052379829 0.487675283789824 no 1627 0.480707972197745 2314 X1424
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.0477980255694409 0.487921519044965 no 1628 0.480938605063469 2311 688669
SGTC_2150 5556613 200 µM 0.0461731055844285 0.488612847156832 no 1629 0.481586139119836 2279 743190
SGTC_3015 9080845 49.47 µM 0.0461028249482731 0.488642749095732 no 1630 0.481614147210639 2300 5296973
SGTC_3306 9127676 59.7925 µM 0.0453425153169923 0.488966238149425 no 1631 0.481917149972757 2259 41905287
SGTC_1199 1638-0010 4.46 µM 0.044789159213247 0.489201679230486 no 1632 0.482137683058511 2299 3111136
SGTC_355 1311-2252 105 µM 0.0444828338555526 0.489332015683204 no 1633 0.482259767515342 2265 5338538
SGTC_2861 9024595 19.48 µM 0.0443914217168551 0.489370910281363 no 1634 0.482296199694082 2331 16482810
SGTC_2187 6125751 200 µM 0.0441776747723157 0.48946185703786 no 1635 0.48238138881334 2281 874498
SGTC_87 0100-0052 35.5 µM 0.0441024636842528 0.489493858582649 no 1636 0.482411364480607 2319 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_999 SEC7.066 22.7 µM 0.0427893586220674 0.490052582003998 no 1637 0.482934723405468 2296 740511 YDR170C SEC7
SGTC_1123 mangostin 811.285 nM 0.0424521491364454 0.490196067119407 no 1638 0.483069128395286 2211 5281650 An antioxidant.
SGTC_803 4488-1585 147 µM 0.0421364172557772 0.490330414506455 no 1639 0.483194974583649 2321 747204
SGTC_1539 benzyladenosine 56 µM 0.0419488440535903 0.490410229487002 no 1640 0.48326973935889 2327 92208 A nucleotide analog.
SGTC_297 0986-0032 24 µM 0.0405334692379444 0.491012503117735 no 1641 0.483833912182471 2321 2847425
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.0401755224099579 0.491164820797008 no 1642 0.483976596078901 2299 279621
SGTC_1374 2889-5571 141 µM 0.0400753441612655 0.491207450037157 no 1643 0.484016529257706 2289 2853281
SGTC_3176 9106582 49.47 µM 0.0393415779692884 0.49151969545176 no 1644 0.484309028916977 2325 17018027
SGTC_3267 9137951 49.47 µM 0.0386783349189977 0.491801935064802 no 1645 0.484573423355875 2296 16643986
SGTC_2765 myclobutanil 7.74 µM 0.0367406084191949 0.492626547442224 no 1646 0.48534591482535 2294 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_898 1000-0849 28.3 µM 0.0367294636847535 0.492631290252476 no 1647 0.485350357932207 2329 6751807
SGTC_1077 5-fluorocytosine 377 nM 0.0363613973329223 0.492787927035031 no 1648 0.485497097138262 2291 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3140 9094243 49.47 µM 0.0361180065529515 0.492891506658275 no 1649 0.485594132270992 2356 19291112
SGTC_337 1315-0038 354 µM 0.0355967428900893 0.49311334202975 no 1650 0.485801952737319 2323 1626437
SGTC_3147 9097027 49.47 µM 0.0345299390476402 0.493567350750659 no 1651 0.486227284335043 2300 25236841
SGTC_453 enantio-paf c16 10 µM 0.0336810240107012 0.493928636674615 no 1652 0.486565755516225 2338 13871343 A lipid and platelet activating factor
SGTC_1174 0739-0097 51.1 µM 0.0336165192694628 0.493956089163989 no 1653 0.486591474620567 2315 728447
SGTC_3342 9147791 14.508 µM 0.0332184113291056 0.494125520035816 no 1654 0.486750208053389 2342 1838168
SGTC_1260 0700-1617 7.75 µM 0.0318022870387117 0.494728217154519 no 1655 0.487314861383624 2307 2853078
SGTC_1092 toremifene 6.32 µM 0.0314954846003603 0.494858792740144 no 1656 0.487437196563551 2349 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1178 0988-0033 191 µM 0.0308140795492458 0.49514880171892 no 1657 0.487708905947921 2328 5392207
SGTC_329 k048-0121 21.3 µM 0.0305579974802685 0.495257792041869 no 1658 0.487811019823994 2262 6832902
SGTC_279 1273-0055 2.93 µM 0.0300740606217262 0.495463759919813 no 1659 0.488003993998073 2351 2847562
SGTC_480 am 92016 50 µM 0.0299418251167596 0.495520040752293 no 1660 0.48805672458526 2266 2129 K+ channel blocker.
SGTC_1434 4073-0095 163 µM 0.0298749352737399 0.495548509812479 no 1661 0.488083397839334 2353 24133745
SGTC_3068 9116768 49.47 µM 0.0294881229852193 0.495713141859182 no 1662 0.48823764565424 2312 41904888
SGTC_1272 0839-0021 27 µM 0.0293411315130245 0.495775703422688 no 1663 0.48829626140405 2323 5027250
SGTC_2357 9067248 200 µM 0.0278687591781582 0.496402370528303 no 1664 0.488883412662587 2309 9150235
SGTC_1834 st055981 52.8 µM 0.0260867190179782 0.497160849340615 no 1665 0.48959408507367 2359 471719 YDL150W RPC53
SGTC_282 k297-0036 65.7 µM 0.0258842671961933 0.49724701836699 no 1666 0.489674824400937 2337 5061378
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.0252171698926865 0.497530954091714 no 1667 0.48994087085856 2365 4000243
SGTC_2011 4012611 177 µM 0.0250051448082777 0.497621198310944 no 1668 0.490025429964648 2342 2049887
SGTC_1145 3546-0597 10.2 µM 0.0248077598849102 0.49770521134914 no 1669 0.490104150735696 2279 875334
SGTC_3302 9125395 16.351 µM 0.023055191008312 0.498451162102427 no 1670 0.490803124285299 2306 17599668
SGTC_2968 9090663 33.37 µM 0.0230512071531353 0.498452857768916 no 1671 0.4908047131913 2276 25236811
SGTC_785 1270-0111 65.3 µM 0.0224778905523953 0.498696881410472 no 1672 0.491033374163703 2372 6741994
SGTC_2353 9059630 146.67 µM 0.022183786337181 0.498822062668568 no 1673 0.491150675518808 2341 4779114
SGTC_1062 mesoridazine 14.2 µM 0.0216031481597317 0.499069203343481 no 1674 0.491382261125245 2362 4078 A neuroleptic.
SGTC_493 zm226600 134 µM 0.0211128149302485 0.499277907238142 no 1675 0.49157783116898 2359 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1766 st045414 44.774 µM 0.0201032868840988 0.499707600141526 no 1676 0.491980489060922 2370 253960
SGTC_1172 0370-0043 85 µM 0.0196695034191711 0.499892234745555 no 1677 0.492153509408814 2343 376585
SGTC_2873 9040596 71.43 µM 0.0195630723842743 0.499937535813397 no 1678 0.492195961080101 2262 6463863
SGTC_1305 1181-0477 144 µM 0.0192695637226428 0.499937535813397 no 1679 0.492313032024902 2365 6252086
SGTC_18 0111-0177 500 nM 0.0192534733777327 0.499930687154882 no 1680 0.492319449953137 2370 721752
SGTC_2647 atorvastatin 60.16 µM 0.0176938904718309 0.499266870168985 no 1681 0.492941527291681 2348 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_323 4013-0906 34.3 µM 0.0175721906734968 0.499215070231381 no 1682 0.492990070939441 2371 2910086
SGTC_1983 st071813 46.9 µM 0.0168610229056594 0.49891237120583 no 1683 0.493273743779444 2287 11838595
SGTC_3184 9108758 49.47 µM 0.0162202049054134 0.498639616147044 no 1684 0.493529358200002 2363 902885
SGTC_1951 sophoraflavanone G 9.2 µM 0.0156153280012247 0.498382159485334 no 1685 0.493770638598661 2380 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1526 st051518 75 µM 0.0152147661971091 0.498211666805109 no 1686 0.493930420652041 2323 673993
SGTC_1212 0520-0165 585 µM 0.0151233457219258 0.498172755196979 no 1687 0.493966887949065 2366 5403258
SGTC_334 1502-1024 68.5 µM 0.0145625023449381 0.497934041915121 no 1688 0.494190607436452 2330 3296216
SGTC_1150 3909-7983 10.9 µM 0.0142673075705113 0.497808397657424 no 1689 0.494308360877897 2363 23965914
SGTC_2014 4013930 200 µM 0.0119726911973515 0.496831744530299 no 1690 0.49522370138148 2388 64556
SGTC_428 3448-4153 16.5 µM 0.0116293735168327 0.49668562038058 no 1691 0.49536065578241 2378 3834874
SGTC_2956 9076196 2.52 µM 0.0114971369968707 0.49662933749805 no 1692 0.495413406994427 2395 16423868
SGTC_1102 cgs 12066b 26.1 µM 0.0112013486064986 0.496503443449297 no 1693 0.495531401889538 2343 6438352 A 5-HT1B full agonist.
SGTC_2558 carylophyllene oxide 100 µM 0.00913738483475104 0.495624985431281 no 1694 0.496354761581777 2388 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2289 7946404 165.07 µM 0.0091273375598595 0.49562070918896 no 1695 0.496358769697392 2387 1246120 YPR165W RHO1
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.00872112725773527 0.495447821573651 no 1696 0.496520817707494 2304 61125 An anti-inflammatory.
SGTC_1324 1418-0026 34.4 µM 0.00854723076208638 0.495373809553547 no 1697 0.496590189786075 2335 1372513
SGTC_1127 asiatic acid 681.4 nM 0.00747902078464679 0.49491917270834 no 1698 0.497016330208665 2389 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2125 5246583 200 µM 0.00678398553109869 0.494623364865644 no 1699 0.49729360210121 2388 835267
SGTC_179 1273-0063 6.77 µM 0.00626195695852779 0.494401190810402 no 1700 0.497501856937441 2392 3108139
SGTC_1288 0973-0013 65.5 µM 0.00623577291125343 0.494390046990515 no 1701 0.497512302657025 2388 4315430
SGTC_3338 9144300 39.5675 µM 0.00460371057311781 0.49369545714669 no 1702 0.498163391693213 2395 4901274
SGTC_2421 5690543 90.72 µM 0.00460337903782069 0.493695316050365 no 1703 0.498163523955259 2369 3397993
SGTC_301 4119-0100 24.5 µM 0.00432413768135697 0.49357647550466 no 1704 0.498274924028591 2394 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3051 9093778 49.47 µM 0.00380677188522331 0.493356294613859 no 1705 0.498481321411133 2401 17217378
SGTC_199 4063-0024 41.6 µM 0.00315629993863343 0.493079469196481 no 1706 0.498740820595557 2392 306215
SGTC_1314 1222-0010 41.1 µM 0.00290606303615257 0.492972975192161 no 1707 0.498840650217191 2392 3526027
SGTC_1897 st060201 15 µM 0.00237164568905093 0.492745543423825 no 1708 0.499053851147474 2399 611878
SGTC_822 1487-0950 154 µM 0.00223324901112608 0.492686646388555 no 1709 0.499109063287374 2402 1958375
SGTC_1029 k015-0030 64.7 µM 0.0017991413634244 0.492501905614084 no 1710 0.499282246828928 2388 2208316
SGTC_1578 josamycin 24.2 µM 0.00112720772514085 0.492215957742539 no 1711 0.499550309274875 2400 5282165 A P450 substrate.
SGTC_2414 st077232 92.9 µM 0.000142004003740705 0.491796702024575 no 1712 0.499943348599112 2404 729801
SGTC_2523 spermine 47.74 µM 0 0.491736272629321 no 1713 0.5 2405 1103 A DNA binding polyamine.
SGTC_1205 4161-2785 76 µM -0.00119823751616891 0.491226373790602 no 1714 0.499521972507227 2410 3498106
SGTC_171 k064-0041 9.68 µM -0.00144045368660318 0.491123302665462 no 1715 0.499425342320181 2404 53325
SGTC_737 1950-0117 57.9 µM -0.00179986050615128 0.49097036407283 no 1716 0.499281959932953 2410 5393513
SGTC_126 0417-1624 672.48 µM -0.00290683277461442 0.490499321959349 no 1717 0.498840343137271 2408 41912 YDL195W SEC31
SGTC_1334 1486-0610 236 µM -0.00320958011757151 0.490370498294285 no 1718 0.498719564987145 2427 3742339
SGTC_2539 epi(13)torulosol 80 µM -0.00428095881063162 0.489914618290119 no 1719 0.498292149746301 2419 6708597
SGTC_789 1309-1135 70.6 µM -0.00476221517572711 0.489709844199534 no 1720 0.498100158199024 2414 3092424
SGTC_1120 ficusin 1.78878 µM -0.0048354134189595 0.489678698658292 no 1721 0.498070956661192 2432 6199 A DNA cross-linker.
SGTC_1879 gemcitabine 100 µM -0.00488524343332133 0.489657496235063 no 1722 0.498051077596433 2418 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3170 9103054 49.47 µM -0.005192793596722 0.489526635819591 no 1723 0.497928384391096 2416 16432970
SGTC_2994 9053520 71.4286 µM -0.0055764784828787 0.489363382201227 no 1724 0.497775318487632 2419 4647384
SGTC_1508 1080-0625 72.9 µM -0.00583195884211949 0.489254679158672 no 1725 0.497673398228956 2394 767111
SGTC_492 tmb-8 126 µM -0.00646837076050728 0.48898389896662 no 1726 0.497419511412864 2417 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2484 5809818 12.04 µM -0.00951040504779969 0.487689648208529 no 1727 0.496205954516623 2440 2870548
SGTC_1546 5-methoxyflavanone 78.7 µM -0.0107643223058661 0.487156198945805 no 1728 0.495705739642261 2424 147795
SGTC_1180 1193-0155 285 µM -0.0122469821647882 0.486525466310759 no 1729 0.495114283141065 2444 2921347
SGTC_245 methotrexate 289.6 µM -0.0134628606692795 0.486008249189748 no 1730 0.494629257904291 2432 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_165 k038-0023 64.381 µM -0.0134867711845728 0.485998078235672 no 1731 0.494619719854749 2432 46368543
SGTC_2698 st077697 67.5 µM -0.0143295528176803 0.485639585208537 no 1732 0.494283531155339 2448 3154499
SGTC_500 h-89 112 µM -0.0188348607836855 0.4837233716442 no 1733 0.492486421933323 2438 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1784 st039334 36.3 µM -0.0196181513363029 0.483390256840467 no 1734 0.492173991973568 2452 3496984
SGTC_1015 4130-4525 82 µM -0.0207878106582203 0.48289285026066 no 1735 0.491707460662507 2456 1363237
SGTC_1955 wogonin 32.4 µM -0.022397648222201 0.482208298212784 no 1736 0.49106537816461 2499 5281703 A flavanone.
SGTC_2777 climbazole 1.536 µM -0.0224372920291187 0.482191441110027 no 1737 0.491049566547383 2447 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_271 rotenone 740 µM -0.0226138513942702 0.482116365978566 no 1738 0.490979147419362 2513 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2111 5486399 200 µM -0.0242511916205193 0.481420180097132 no 1739 0.490326122555694 2438 689674
SGTC_1266 0828-0227 32.9 µM -0.0242952983684709 0.481401426983327 no 1740 0.490308531692034 2466 3913820
SGTC_2292 7671323 168.05 µM -0.0248353132171124 0.481171829185669 no 1741 0.490093161932185 2485 937504
SGTC_2475 5812728 15.03 µM -0.0253079899743125 0.480970866608154 no 1742 0.489904650447843 2439 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2845 9003024 42.97 µM -0.0268775289695904 0.480303598614273 no 1743 0.489278708163186 2481 2990173
SGTC_883 0850-0245 24.6 µM -0.0269578515922008 0.480269452020578 no 1744 0.489246675679826 2573 6823229 YPR165W RHO1
SGTC_487 nimodipine 119 µM -0.0273369420983907 0.480108295776322 no 1745 0.489095496168204 2458 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.0274096070248845 0.480077405353092 no 1746 0.48906651791541 2467 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3305 9127027 53.8275 µM -0.0275174830855655 0.480031546624629 no 1747 0.489023497820715 2481 41905295
SGTC_532 1548-0774 215 µM -0.0276559603698513 0.479972679529009 no 1748 0.488968274394446 2491 5932993
SGTC_73 0327-0325 16.231 µM -0.0283701045668406 0.479669101720282 no 1749 0.488683483849778 2476 53298
SGTC_3258 9138477 49.47 µM -0.0284927162879994 0.479616981498355 no 1750 0.488634588616271 2466 4970355
SGTC_3056 9094900 49.47 µM -0.028712723384295 0.479523460981913 no 1751 0.488546854379462 2475 25236784
SGTC_3291 9121177 71.43 µM -0.0293618517811559 0.479247536367008 no 1752 0.488287998772968 2484 17015612
SGTC_1283 0922-0125 16.4 µM -0.0310446983548853 0.478532256428474 no 1753 0.487616946351941 2483 3360884
SGTC_932 2857-0803 154 µM -0.03314722349113 0.477638693027072 no 1754 0.486778592260583 2629 674898
SGTC_551 k048-0028 34.9 µM -0.0338202081160478 0.477352701225367 no 1755 0.486510260708071 2483 6836383
SGTC_72 0744-0168 198.391 µM -0.0340654666187136 0.477248478970975 no 1756 0.486412473069565 2515 677577
SGTC_1243 0416-0003 5.65 µM -0.0350240061555973 0.476841163940049 no 1757 0.486030299234965 2494 2141977
SGTC_645 0845-0943 5.41 µM -0.0354228635065459 0.476671683414089 no 1758 0.485871276854249 2492 1885106
SGTC_1203 3992-3522 103 µM -0.0369575443974044 0.476019613897694 no 1759 0.485259428629441 2478 5322312
SGTC_2858 9025781 8.96 µM -0.0374923993158285 0.475792374756903 no 1760 0.485046200177508 2499 4894980 YPL153C RAD53
SGTC_3288 9119690 36.221 µM -0.0379989098711792 0.475577185295441 no 1761 0.484844275599363 2511 17595618 YKL019W RAM2
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.039363270683886 0.474997576386589 no 1762 0.484300381474313 2492 688801
SGTC_2476 5806916 10.51 µM -0.0393923621542172 0.474985218295435 no 1763 0.484288784651375 2499 2870194
SGTC_1461 k072-0203 53.8 µM -0.039881716788683 0.474777343482098 no 1764 0.484093713697215 2456 5418714
SGTC_2675 theaflavin digallate 100 µM -0.0400819796832832 0.474692275023397 no 1765 0.484013884192657 2503 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2782 7736369 71.43 µM -0.0407251877744354 0.474419058388241 no 1766 0.483757490654609 2489 2950836 YOL077C BRX1
SGTC_2420 aureobasidin a 50 nM -0.0417904920310801 0.473966573745365 no 1767 0.483332857326457 2570 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_589 1227-0070 34.1 µM -0.0424189318776058 0.473699661602734 no 1768 0.483082368237918 2522 2841384
SGTC_1328 1441-0025 69.2 µM -0.0425034256352059 0.473663776154333 no 1769 0.483048690478966 2475 4562601
SGTC_255 tunicamycin 200.472 nM -0.042526209747456 0.473654099522383 no 1770 0.483039609144278 2484 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1224 0823-0416 294 µM -0.043186572398535 0.473373643921041 no 1771 0.482776404388336 2523 3598164
SGTC_3172 9105863 49.47 µM -0.0438165759722458 0.473106094100055 no 1772 0.482525307029248 2474 2348785
SGTC_2603 homopterocarpin 100 µM -0.0445994535079812 0.472773638707263 no 1773 0.482213289132708 2524 101795 A weak amylase inhibitor.
SGTC_3198 9112019 49.47 µM -0.0458033804974123 0.472262418285581 no 1774 0.481733482196624 2508 45595555
SGTC_3135 9127742 49.47 µM -0.0459979522927946 0.472179802031259 no 1775 0.481655941008682 2554 3643468
SGTC_2575 plumbagin 510 nM -0.0465411146039385 0.471949178672683 no 1776 0.48143948242917 2478 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1811 st050069 61.5 µM -0.0470734343808345 0.471723168111639 no 1777 0.481227350075912 2487 3877702
SGTC_150 3970-0969 77.2 µM -0.0477089417046119 0.471453358455409 no 1778 0.480974103884885 2620 6615640
SGTC_2544 sphondin 68.51 µM -0.0484025024715937 0.471158916706543 no 1779 0.480697732480238 2509 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_590 k048-0076 22.4 µM -0.0488016056696419 0.470989490031562 no 1780 0.480538701280854 2517 6832814
SGTC_1433 4060-0023 7.6 µM -0.0488576924774271 0.470965680566395 no 1781 0.480516352541183 2557 3840627
SGTC_1934 st074720 32.6 µM -0.049159450123355 0.470837582918849 no 1782 0.480396113142886 2489 17250992
SGTC_2297 7971671 152.32 µM -0.0492765349591738 0.470787880625399 no 1783 0.480349459592776 2537 909016
SGTC_1721 st082152 9.2685 µM -0.0498564549617398 0.470541712394165 no 1784 0.480118389013575 2496 5296051
SGTC_1594 piperine 70.1 µM -0.0502498611893319 0.470374723151236 no 1785 0.479961639114281 2496 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2726 cimetidine 79.27 µM -0.0511603399755591 0.469988272015379 no 1786 0.479598877275078 2492 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2534 helenine 20.12 µM -0.0511931542329228 0.469974344586516 no 1787 0.479585803412244 2502 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3312 9133330 71.43 µM -0.0513466414003979 0.469909200171733 no 1788 0.479524651316812 2603 17617324
SGTC_2560 caryophyllene 100 µM -0.0515007919388601 0.469843775013657 no 1789 0.479463235407314 2502 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_155 k072-0202 43.6 µM -0.0517283200122919 0.469747208171182 no 1790 0.479372585667776 2480 5857737
SGTC_584 0986-0246 15.4 µM -0.0524008139217823 0.469461800569093 no 1791 0.479104662797034 2494 53315 YDR232W HEM1
SGTC_1986 st071812 45 µM -0.0525305466844173 0.469406743556527 no 1792 0.47905297809676 2510 11838594
SGTC_3231 9132313 49.47 µM -0.0531421919999983 0.469147176593325 no 1793 0.478809307286748 2535 4905967
SGTC_1665 st014639 11.4 µM -0.0551353716624501 0.468301412592988 no 1794 0.478015308239911 2511 981133 YIL048W NEO1
SGTC_2685 mycophenolic acid 18.85 µM -0.0559215772193302 0.467967841878094 no 1795 0.477702140794653 2546 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1791 st048313 56.1 µM -0.0562512896791888 0.467827958398343 no 1796 0.477570811278007 2507 1204976
SGTC_1545 lovastatin 49.4 µM -0.0564580855866795 0.467740225398696 no 1797 0.477488442546545 2541 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1131 3454-3128 32.3 µM -0.0568166886366887 0.467588092056361 no 1798 0.477345609901419 2683 710982
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.057757123877529 0.467189145443331 no 1799 0.476971045660708 2528 165506
SGTC_739 1486-1183 203 µM -0.0580164627705654 0.467079135809106 no 1800 0.476867757609639 2504 4346692
SGTC_622 1348-1566 26.3 µM -0.0595210620358795 0.466440945843974 no 1801 0.476268545068427 2575 7340407
SGTC_124 0136-0217 7.121 µM -0.0598457293548187 0.466303246400315 no 1802 0.476139252031458 2527 3976905
SGTC_2546 rhodinyl acetate 100 µM -0.0631198786330852 0.4649148268955 no 1803 0.474835522500341 2537 6708682
SGTC_2287 7945887 168.79 µM -0.0640327480823086 0.464527795411719 no 1804 0.474472075552635 2541 1245853
SGTC_2564 betulinic acid 100 µM -0.0641035216234637 0.464497790778198 no 1805 0.474443898882877 2512 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1215 3852-0577 11.2 µM -0.0661060193022227 0.463648910798883 no 1806 0.473646709313148 2637 2884876
SGTC_1701 st028638 40.4 µM -0.0668164662905867 0.463347784362079 no 1807 0.473363907249702 2524 3490878
SGTC_2248 tofa 1.1 µM -0.067747351939213 0.462953255729149 no 1808 0.472993377237316 2524 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_947 3447-0010 211 µM -0.0688476109768739 0.462486990158882 no 1809 0.472555459944461 2512 748350
SGTC_1929 genistein trimethyl ether 50.5 µM -0.0689264205559197 0.46245359436392 no 1810 0.472524093981996 2530 136420
SGTC_2646 retinol 96.75 µM -0.0690187245232865 0.462414480618066 no 1811 0.472487357512439 2591 445354 A vitamin A analog and teratogen.
SGTC_899 1083-0020 478 µM -0.0691967441853886 0.462339045929301 no 1812 0.472416507330687 2668 767123
SGTC_231 b-estradiol 524 µM -0.0692125997351523 0.462332327307551 no 1813 0.47241019701058 2526 450 A steroid.
SGTC_360 0957-0399 1.01 µM -0.0699311799368975 0.462027847846702 no 1814 0.472124217935351 2604 6752301 YPR165W RHO1
SGTC_2362 9071156 126 µM -0.0719684867883679 0.461164714217491 no 1815 0.471313493348798 2594 653133
SGTC_3027 9089541 49.47 µM -0.0720637733086198 0.461124349192318 no 1816 0.471275577975409 2613 9943819
SGTC_276 colchicine 750 µM -0.0726928659265515 0.460857864701932 no 1817 0.471025262848433 2641 2833 A microtubule depolymerizer.
SGTC_2423 st077119 87.2 µM -0.0737817188667708 0.460396666719707 no 1818 0.470592036801618 2496 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2589 lobaric acid 100 µM -0.0738849772227197 0.460352933040942 no 1819 0.470550954806827 2570 73157 A novel microtubule depolymerizer.
SGTC_817 1391-0715 46 µM -0.0750872076845664 0.45984378004105 no 1820 0.470072662939801 2593 1353946
SGTC_2762 leflunomide 42.06 µM -0.075223928417335 0.459785882009769 no 1821 0.470018273082776 2553 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1715 st032160 10.2275 µM -0.0763597021818336 0.459304941477647 no 1822 0.46956646448125 2579 5289825
SGTC_272 doxorubicin 8.13 µM -0.0765302779581636 0.459232716722096 no 1823 0.469498613138146 2514 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_930 2810-3379 265 µM -0.0765821876333653 0.45921073752815 no 1824 0.469477964771254 2579 1015764
SGTC_1049 3226-0134 66 µM -0.0772038297603711 0.45894753632313 no 1825 0.469230697517167 2508 5702385
SGTC_246 cycloheximide 667 µM -0.0780247861528658 0.458599973714815 no 1826 0.468904168296493 2537 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2380 9035439 200 µM -0.0785227148631933 0.458389184495206 no 1827 0.468706131078767 2679 6462575
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0791856218907467 0.458108572822324 no 1828 0.468442490374084 2629 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2457 5731572 11.68 µM -0.079384873808685 0.458024232619681 no 1829 0.468363249810569 2548 2865357
SGTC_2919 7978188 46.38 µM -0.0798311093371673 0.457835355001392 no 1830 0.46818579080179 2555 2980291
SGTC_2133 5320837 200 µM -0.0808797986746129 0.457391514982963 no 1831 0.467768772823131 2637 2841355
SGTC_1966 st070145 16.1 µM -0.081197963566341 0.457256867556739 no 1832 0.467642259504491 2535 3748532
SGTC_2048 5246248 200 µM -0.081356174747567 0.457189914388466 no 1833 0.467579350505896 2577 677046
SGTC_3125 9127534 49.47 µM -0.0820693994113807 0.456888100954585 no 1834 0.467295763372935 2546 1639235
SGTC_1808 st050063 61.5 µM -0.0825942626652906 0.456666011803806 no 1835 0.46708708170934 2541 4011993
SGTC_6 0844-0013 19.835 µM -0.0846567304200987 0.455793436783859 no 1836 0.46626714827198 2582 1584900
SGTC_919 tnp00227 403.569 nM -0.084684087380867 0.455781864207767 no 1837 0.46625627347475 2600 1269246 A methoxyflavone. YNL221C POP1
SGTC_2851 9015922 71.43 µM -0.0847579134793172 0.455750634385621 no 1838 0.466226926632553 2631 2996893
SGTC_2719 novobiocin 32.65 µM -0.0850374281631725 0.455632396918759 no 1839 0.466115817545642 2576 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1370 2001-0092 44.6 µM -0.0850626175741633 0.455621741742442 no 1840 0.466105804704124 2596 790957
SGTC_740 k014-0057 261 µM -0.0861892824462895 0.455145192777091 no 1841 0.465657975186195 2652 4012779
SGTC_2179 6298986 200 µM -0.0863501306655911 0.455077163551406 no 1842 0.465594044375373 2613 738374
SGTC_3283 9109332 35.8195 µM -0.0864070295805583 0.455053099011408 no 1843 0.465571429517711 2528 17027281
SGTC_459 nigericin 15.3 µM -0.0866507872228062 0.454950007252091 no 1844 0.465474547657471 2641 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_471 1-acyl-paf 4 µM -0.0866709969443037 0.454941460145431 no 1845 0.465466515363498 2555 16759367
SGTC_172 1112-0046 2.638 µM -0.0887629870239387 0.454056828097703 no 1846 0.464635136807677 2605 2802135 YIL048W NEO1
SGTC_3014 9081533 49.47 µM -0.0889269182456565 0.4539875166839 no 1847 0.464569995315099 2605 21367265
SGTC_3209 9113616 49.47 µM -0.0890576931118789 0.453932225043481 no 1848 0.464518029873285 2582 16649353
SGTC_2920 7982904 15.77 µM -0.0908082825056107 0.453192161878341 no 1849 0.463822464378959 2646 6456808
SGTC_832 4083-0019 164 µM -0.0922278882901302 0.452592141543224 no 1850 0.463258490408329 2680 1990758
SGTC_2372 9071633 200 µM -0.0930178991083296 0.45225827693438 no 1851 0.462944670719967 2563 21321366
SGTC_2734 clemastine 41.6 µM -0.0940570588123847 0.45181917154192 no 1852 0.462531915602625 2565 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_606 k015-0008 38.6 µM -0.0945655030325194 0.451604345737213 no 1853 0.462329975796842 2619 1970475
SGTC_2461 5755302 26.15 µM -0.0945968106614117 0.451591118226441 no 1854 0.462317541600188 2698 2788904
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.0959260773545624 0.451029551223569 no 1855 0.461789641673417 2617 390807
SGTC_1735 st034310 56.75 µM -0.0973975804158381 0.450408008846587 no 1856 0.461205333071684 2801 871153
SGTC_2191 5911152 200 µM -0.0974789546597505 0.450373641034907 no 1857 0.461173023188395 2591 2875902
SGTC_495 decylubiquinone 155 µM -0.097745129382616 0.450261226704821 no 1858 0.461067339521837 2630 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2057 5236571 38.335 µM -0.0977765518521581 0.450247956226789 no 1859 0.461054863530513 2612 54684039 YBR257W POP4
SGTC_1467 k284-1082 293 µM -0.0983546003700168 0.450003842127847 no 1860 0.460825361740181 2600 3334705
SGTC_1634 st006576 41 µM -0.0992179365263393 0.449639284233554 no 1861 0.460482616919069 2624 3915356
SGTC_1833 st055984 71 µM -0.0999362078352783 0.449336014732811 no 1862 0.460197485266018 2623 676288
SGTC_2373 9071805 200 µM -0.101077754619521 0.448854090238926 no 1863 0.459744368417296 2592 10149009
SGTC_404 fumagillin 50 µM -0.101771688231804 0.448561170519913 no 1864 0.459468949229514 2616 12015870 A methionine aminopeptidase binder.
SGTC_2935 9038016 29.96 µM -0.103837269368959 0.447689424504341 no 1865 0.458649244820367 2614 6463195
SGTC_3225 9130819 49.47 µM -0.104437858194159 0.447436002656932 no 1866 0.458410940220884 2596 4547121
SGTC_3201 9113999 49.47 µM -0.105202633088365 0.447113332641572 no 1867 0.458107510708211 2787 16649224
SGTC_2781 5567276 71.43 µM -0.105905402364391 0.446816854584551 no 1868 0.457828703854926 2746 2853274
SGTC_831 k061-1017 217 µM -0.106409032537915 0.446604405834673 no 1869 0.457628913419372 2674 1240153
SGTC_55 0767-0285 6.563 µM -0.107301490819388 0.446227973521035 no 1870 0.457274900934814 2601 3116166
SGTC_1860 st056228 74.6 µM -0.108606319563006 0.445677693696656 no 1871 0.4567573740609 2713 688679
SGTC_696 1560-0013 611 µM -0.110170286166023 0.445018266724822 no 1872 0.456137163501075 2734 1650269
SGTC_1442 4112-3290 3 µM -0.110229768962006 0.444993189538592 no 1873 0.456113576952564 2598 704353
SGTC_1278 0874-0585 172 µM -0.11243335721835 0.444064340876625 no 1874 0.455239903881781 2656 766306
SGTC_2003 4023581 200 µM -0.113058078259647 0.443801066354035 no 1875 0.454992255266278 2695 16641307
SGTC_2317 5986382 200 µM -0.113829761756523 0.443475892086585 no 1876 0.454686372727324 2664 877883
SGTC_1726 st035556 14.5795 µM -0.114961731268002 0.442998968355372 no 1877 0.454237727450674 2842 5919439
SGTC_1817 st052116 64.4 µM -0.116027111653984 0.442550175508879 no 1878 0.453815527455599 2718 4361398
SGTC_1385 3091-4834 14.1 µM -0.118993727706089 0.441300874888099 no 1879 0.452640162520277 2713 4072814
SGTC_1949 st076024 69.1 µM -0.119087577328676 0.441261362419936 no 1880 0.452602986279459 2585 2921930
SGTC_2723 salbutamol 83.58 µM -0.12054435085941 0.440648108390055 no 1881 0.452025974428164 2696 9884233 β2-adrenoceptor agonist
SGTC_926 2268-1401 59.4 µM -0.121267927462701 0.440343559104466 no 1882 0.451739411339322 2622 2931578
SGTC_1464 k208-0027 110 µM -0.121575768759692 0.44021400113948 no 1883 0.451617502419026 2673 X1464
SGTC_1075 aripiprazole 15.2 µM -0.121814485864555 0.440113539159885 no 1884 0.451522970664797 2611 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3158 9100007 49.47 µM -0.12280581831806 0.439696386996093 no 1885 0.451130433393812 2650 19297233
SGTC_735 3076-0345 636 µM -0.123289022579394 0.43949307914176 no 1886 0.450939116613675 2718 2888990
SGTC_2402 5553605 200 µM -0.124008969426434 0.439190191626771 no 1887 0.450654086654644 2760 6758546
SGTC_1944 st076371 56.9 µM -0.124050904242975 0.439172550402647 no 1888 0.450637485268746 2625 24208455
SGTC_693 4161-2696 114 µM -0.12421158644236 0.439104955406049 no 1889 0.450573874315264 2736 805759
SGTC_3210 9128157 49.47 µM -0.124550886026775 0.438962226363359 no 1890 0.450439556390452 2782 17590849
SGTC_890 0929-0006 47.2 µM -0.126521203686242 0.43813355414972 no 1891 0.449659682899453 2630 1378169
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.127083449903633 0.437897135352123 no 1892 0.449437175156234 2618 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3260 9137109 49.47 µM -0.127457414519979 0.437739899316098 no 1893 0.449289188255122 2610 17478346
SGTC_1485 3909-9022 254 µM -0.128796029822994 0.437177149903287 no 1894 0.448759523553659 2638 714516
SGTC_3 0833-0587 95.581 µM -0.129000312996309 0.437091281086359 no 1895 0.448678700581696 2621 5382644
SGTC_2467 5474540 200 µM -0.129299287384521 0.436965614909296 no 1896 0.44856041764308 2632 5413519
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.129382614419057 0.436930591671135 no 1897 0.448527451865956 2766 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_709 3807-1509 243 µM -0.131129177762834 0.43619660671399 no 1898 0.44783655996347 2618 1886677 YPL242C IQG1
SGTC_1014 4130-3005 69.3 µM -0.131179416712211 0.436175497271974 no 1899 0.447816689162789 2650 743608
SGTC_2883 9059145 45.46 µM -0.131782838464751 0.435921965258587 no 1900 0.447578030537582 2615 16476510
SGTC_2034 5197015 53.07 µM -0.132763179408481 0.435510124101806 no 1901 0.447190337546649 2775 780676
SGTC_189 3970-0742 2.116 µM -0.133024057205192 0.435400541122083 no 1902 0.447087177339096 2657 2891807
SGTC_1452 4194-0072 190 µM -0.133050027962683 0.435389632251203 no 1903 0.447076907788824 2808 1343545
SGTC_403 arphamenine a 50 µM -0.133372113257195 0.435254346220254 no 1904 0.44694954937495 2635 5487158 An arginine aminopeptidase inhibitor.
SGTC_3181 9108277 49.47 µM -0.134407810557777 0.434819371972787 no 1905 0.446540052872933 2660 17097298
SGTC_3104 9120930 49.47 µM -0.134468074399068 0.434794064666091 no 1906 0.446516227360359 2721 17014836
SGTC_523 1934-0222 13.7 µM -0.135611873760788 0.434313786259149 no 1907 0.446064059135527 2655 1361595
SGTC_2177 5811945 192 µM -0.136212076308288 0.434061801488733 no 1908 0.445826814317126 2785 5343475
SGTC_3206 9114350 49.47 µM -0.136386964821268 0.433988382574993 no 1909 0.445757688976459 2718 17087243
SGTC_1569 carminic acid 40.6 µM -0.137176457911288 0.433656978522743 no 1910 0.445445659423503 2705 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_32 0928-0142 34.1 µM -0.137190984791499 0.433650881037378 no 1911 0.445439918313793 2655 2244242
SGTC_1969 st069479 40.1 µM -0.137238798407712 0.433630811951604 no 1912 0.445421022168275 2778 3895485
SGTC_1274 0865-0114 173 µM -0.137635513807833 0.433464302905909 no 1913 0.445264243332676 2714 870624
SGTC_790 1575-0012 79.1 µM -0.138144217134103 0.433250807667875 no 1914 0.445063220270375 2667 378741 YLR208W SEC13
SGTC_1912 st060209 90.8 µM -0.13835846772653 0.433160895698966 no 1915 0.444978559607012 2729 688787
SGTC_896 0964-0007 44.5 µM -0.139317752593427 0.432758366645702 no 1916 0.444599531070937 2628 6756758
SGTC_3196 9111891 49.47 µM -0.139486732789311 0.432687467459214 no 1917 0.44453276957562 2603 18891510
SGTC_846 0335-0850 148 µM -0.140332696913126 0.432332558087493 no 1918 0.444198565762673 2658 6819598
SGTC_2330 7979373 200 µM -0.141034322055664 0.43203824500038 no 1919 0.443921414121297 2695 1863007
SGTC_1650 st011916 45.8 µM -0.14120199400627 0.431967916653553 no 1920 0.443855185435196 2686 242528
SGTC_509 pifithrin 175 µM -0.14148060308237 0.431851061591604 no 1921 0.443745141200272 2661 4817 A p53 inhibitor.
SGTC_2517 totarol 10 µM -0.142340032085299 0.431490634887089 no 1922 0.443405713696431 2709 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1764 st044502 93.5 µM -0.142885919845895 0.431261730477153 no 1923 0.443190139400222 2759 8407
SGTC_1487 3970-0795 2.82 µM -0.142956401434276 0.431232177462995 no 1924 0.443162307029563 2733 3765103
SGTC_2766 oltipraz 83.91 µM -0.144680369710743 0.43050943577556 no 1925 0.442481619383485 2765 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1362 1611-0397 101 µM -0.145884134245163 0.430004917676656 no 1926 0.442006428312125 2677 27816
SGTC_2020 4017018 200 µM -0.146948369500492 0.429558973798835 no 1927 0.441586386478031 2766 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3116 9124943 49.47 µM -0.147310533855768 0.429407237427623 no 1928 0.441443459186151 2677 41905195 YPL160W CDC60
SGTC_879 0831-1030 162 µM -0.147684258613511 0.429250668516731 no 1929 0.441295977603476 2680 1549252
SGTC_2627 acetyl isogambogic acid 100 µM -0.149247782949301 0.428595763824191 no 1930 0.440679058421891 2765 6857789 A caspase activator and apoptosis inducer.
SGTC_2594 a-mangostin 100 µM -0.14997596734021 0.428290820285125 no 1931 0.440391788034398 2815 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2962 9082311 13.18 µM -0.150254591094183 0.428174151656862 no 1932 0.440281878623991 2682 16459453
SGTC_2482 5981709 142.65 µM -0.150500150296392 0.428071333412577 no 1933 0.440185016084458 2744 877755
SGTC_1855 st056195 39.6 µM -0.153003778020372 0.427023317809171 no 1934 0.439197647971894 2838 4028379
SGTC_2210 7115885 190.385 µM -0.155149964252708 0.426125336355657 no 1935 0.43835154663255 2682 2927039
SGTC_1915 st067105 30.6 µM -0.155472179129824 0.425990552024229 no 1936 0.438224542536119 2648 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1552 6-methylflavone 10.6 µM -0.156103492969944 0.425726494901737 no 1937 0.437975722563362 2679 689013
SGTC_2086 5274770 176.623 µM -0.157401810590124 0.425183557569327 no 1938 0.437464093299686 2742 689278
SGTC_2932 9016711 44.54 µM -0.158765057556256 0.424613620436888 no 1939 0.436926989799579 2754 7117328
SGTC_506 n9-isopropylolomoucine 153 µM -0.161405764039861 0.423510060867016 no 1940 0.435886913575246 2696 6610355
SGTC_659 k018-0002 107 µM -0.162592775825043 0.423014199752758 no 1941 0.435419537678958 2776 6797879 YHR007C ERG11
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.16348111348557 0.422643186197044 no 1942 0.435069821177234 2661 2333 A French combination drug.
SGTC_691 1548-0686 185 µM -0.164538188762127 0.422201788927202 no 1943 0.434653743053873 2717 46495133
SGTC_968 1309-0633 340 µM -0.165062465141436 0.421982905851164 no 1944 0.434447408093707 2769 3761976
SGTC_1496 4469-0713 57.4 µM -0.165220994192311 0.42191672541332 no 1945 0.434385020687392 2735 746691
SGTC_2350 9023895 38.85 µM -0.165294629250036 0.421885986053817 no 1946 0.434356042956506 2830 2997209
SGTC_2900 5328528 85.29 µM -0.166097511721343 0.421550849277666 no 1947 0.434040106158266 2687 795359
SGTC_1054 3429-0080 167 µM -0.166293613880778 0.421469001530918 no 1948 0.433962945730822 2830 1162877
SGTC_1422 4031-0024 15.5 µM -0.16642426683489 0.421414472398496 no 1949 0.433911539035653 2685 782427
SGTC_3005 9076496 71.4286 µM -0.166637026376459 0.421325678602507 no 1950 0.433827829085264 2756 21368410
SGTC_2693 st077581 40.7 µM -0.167038420902049 0.421158170133886 no 1951 0.433669909042697 2732 25238761
SGTC_2489 cantharidin 73.42 µM -0.167224702674894 0.421080436564326 no 1952 0.43359662408142 2697 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1379 2144-0755 36.5 µM -0.168220945630946 0.420664766374652 no 1953 0.433204731759393 2802 5392327
SGTC_100 0086-0128 49.5915 µM -0.168612223246102 0.420501534738599 no 1954 0.433050832733881 2741 93297
SGTC_2504 purpurogallin 52.29 µM -0.168885415087859 0.420387573757204 no 1955 0.432943385739843 2708 5281571 An antioxidant.
SGTC_85 0868-0259 160.055 µM -0.169782538890218 0.420013388818559 no 1956 0.432590579748196 2760 83173
SGTC_1668 st014914 51.6 µM -0.170299613297746 0.419797753014151 no 1957 0.432387257681339 2707 2839556
SGTC_133 0724-0033 378.92 µM -0.171120937961053 0.419455285092377 no 1958 0.432064336290917 2677 280309
SGTC_858 0438-0351 2.77 µM -0.171359156554899 0.419355966435065 no 1959 0.431970684027144 2723 2799119
SGTC_2692 st077426 47.7 µM -0.171855571662985 0.419149016394634 no 1960 0.431775537752978 2826 25238571
SGTC_809 3998-0021 90 µM -0.172193108542732 0.419008313724534 no 1961 0.431642857774341 2758 715485
SGTC_1073 triclabendazole 3.09 µM -0.172750892200818 0.418775823619606 no 1962 0.431423619458917 2771 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1346 1488-2224 62.4 µM -0.173191179937674 0.418592327080347 no 1963 0.431250578135461 2710 3722427
SGTC_692 k241-0027 77.8 µM -0.174336377806003 0.418115131684083 no 1964 0.43080055580706 2864 3600480
SGTC_1716 st033144 30.6155 µM -0.174361120383527 0.418104822964407 no 1965 0.430790833837091 2810 674617
SGTC_2786 7743617 45.45 µM -0.174858966889073 0.417897412720441 no 1966 0.430595226565872 2757 583674
SGTC_3221 9128209 49.47 µM -0.176399029725783 0.417255944501415 no 1967 0.429990233439783 2757 16460723
SGTC_1696 st025591 34.7925 µM -0.176984448475649 0.417012163071693 no 1968 0.429760302530235 2734 2787147
SGTC_1765 st044815 90.4 µM -0.177455471715015 0.41681604164223 no 1969 0.429575319251831 2801 645695
SGTC_1981 st071826 47 µM -0.177518495408005 0.416789801837883 no 1970 0.429550569353359 2813 11838600
SGTC_2749 bexarotene 57.39 µM -0.177519347337702 0.416789447140983 no 1971 0.429550234795782 2822 82146 An retinoic acid receptor inhibitor.
SGTC_37 0566-0070 1.56 µM -0.177650714265689 0.416734753952561 no 1972 0.429498646870998 2826 1626686
SGTC_1997 st073024 93.8 µM -0.179584263951767 0.415929928603235 no 1973 0.428739479688088 2738 686268
SGTC_50 0929-0078 56.389 µM -0.179748411412382 0.415861619655183 no 1974 0.428675042775664 2780 1377751
SGTC_1899 st063254 59.6 µM -0.180819282655575 0.415416045703141 no 1975 0.428254713610911 2703 3093813
SGTC_716 1683-5115 658 µM -0.180984285207407 0.41534740019547 no 1976 0.428189955453397 2702 723597
SGTC_503 tyrphostin 8 294 µM -0.181893209003317 0.414969309776899 no 1977 0.427833267014054 2823 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_129 0088-0017 176.636 µM -0.182298358789983 0.414800802570519 no 1978 0.427674293300455 2775 182446
SGTC_2979 9012552 45.46 µM -0.183511671905782 0.414296263325075 no 1979 0.427198280714859 2827 17100905
SGTC_213 1246-0773 967 nM -0.183532462454095 0.414287619096909 no 1980 0.427190124992852 2750 6251622
SGTC_1878 temozolomide 1 mM -0.184954972442552 0.413696271229337 no 1981 0.426632176473237 2745 5394 DNA alkylating agent.
SGTC_800 3448-7362 155 µM -0.186325855720592 0.413126570089472 no 1982 0.426094616275732 2801 15991913
SGTC_571 k831-0106 44.2 µM -0.186689825693637 0.412975344919488 no 1983 0.425951916886164 2773 4783639
SGTC_2813 7971799 71.43 µM -0.187384323767534 0.412686825122564 no 1984 0.425679656366016 2857 2234054
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.187388127250002 0.412685245147129 no 1985 0.425678165403711 2785 676296 Flavone; oxidizing agent.
SGTC_2140 5586273 200 µM -0.187615598715638 0.412590755546013 no 1986 0.425588998690902 2713 854421
SGTC_2910 7948405 25.97 µM -0.190872115967351 0.411238585460639 no 1987 0.424312893373592 2849 2971328
SGTC_1695 st026914 34.495 µM -0.190903129277028 0.411225713164111 no 1988 0.424300744227567 2719 3289191
SGTC_3069 9117009 49.47 µM -0.191320789232878 0.411052369720903 no 1989 0.424137137234526 2784 41904981
SGTC_687 k029-0044 34.9 µM -0.191547464893572 0.410958298686961 no 1990 0.424048348645438 2888 5829338
SGTC_964 1287-0107 19.4 µM -0.191959796978961 0.410787192849505 no 1991 0.423886848540948 2881 51516812 YPR165W RHO1
SGTC_2136 5328288 199.296 µM -0.193818629705851 0.410016042473633 no 1992 0.42315894961004 2791 262395
SGTC_2100 5377183 190 µM -0.194165501904046 0.409872178427365 no 1993 0.423023147139376 2841 2844202
SGTC_2371 9071574 200 µM -0.196222519646128 0.409019287347223 no 1994 0.422218001273279 2777 45596039
SGTC_2715 st079500 56.4 µM -0.196754396035791 0.408798827970397 no 1995 0.4220098700607 2732 28246688
SGTC_1540 guanosine 70.6 µM -0.196781045698188 0.408787782613481 no 1996 0.421999442220401 2727 6802 Guanosine is a purine nucleoside
SGTC_2961 9083290 32.55 µM -0.200068154055029 0.407425948847439 no 1997 0.420713639597271 2783 17741490
SGTC_1796 st049173 110.4 µM -0.200885239406245 0.407087607040711 no 1998 0.420394154846077 2739 94134
SGTC_1295 1013-0063 9.78 µM -0.20221322914514 0.406537855998502 no 1999 0.419875015699365 2851 6826038
SGTC_1994 st072947 40.9 µM -0.203230807213618 0.406116731367718 no 2000 0.41947731728816 2865 5286565 YDL195W SEC31
SGTC_1500 4488-1866 171 µM -0.203260450561224 0.406104465095375 no 2001 0.419465733056773 2925 2900003
SGTC_2788 5282734 71.43 µM -0.204255999471584 0.40569256542052 no 2002 0.41907672619856 2926 743706
SGTC_2448 5185112 27.17 µM -0.205133093603351 0.405329761862576 no 2003 0.418734070609961 2909 5718189
SGTC_689 0833-0039 98 µM -0.206080100467938 0.404938130734642 no 2004 0.418364171335804 2821 5374726
SGTC_1144 3486-0183 12.5 µM -0.207372084508996 0.404403989181209 no 2005 0.417859641037697 2782 6744069
SGTC_2814 7977482 42.97 µM -0.20889953171466 0.403772730564134 no 2006 0.417263334867017 2936 6456762
SGTC_427 1354-0053 47.3 µM -0.210067233474543 0.403290315319575 no 2007 0.416807599385458 3012 6813657
SGTC_2268 7933382 153.85 µM -0.210295507546832 0.403196025111039 no 2008 0.416718520677415 2728 935025 YOR257W CDC31
SGTC_370 0180-0345 38.7 µM -0.210729837153467 0.403016637762629 no 2009 0.416549045346683 2705 3989527
SGTC_3090 9117696 49.47 µM -0.211726330687946 0.402605141969536 no 2010 0.416160272423964 2869 7923821
SGTC_2281 7943571 200 µM -0.213457170633687 0.401890659071253 no 2011 0.415485196065029 2940 1244024
SGTC_1378 2093-0007 380 nM -0.213897184739286 0.401709075398329 no 2012 0.415313617841662 2896 3618014
SGTC_650 1328-0195 38 µM -0.214818951525495 0.401328752332956 no 2013 0.414954238321067 2807 2780821
SGTC_227 fluconazole 33.516 µM -0.21513431275023 0.40119865501716 no 2014 0.414831301236901 2813 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1670 st016595 4.04 µM -0.216755024085096 0.400530229130736 no 2015 0.414199632099689 2795 597879
SGTC_516 3992-2719 87.3 µM -0.2170050669799 0.400427130449936 no 2016 0.414102198075927 2730 5350887 YDR037W KRS1
SGTC_3355 9151058 44.0485 µM -0.217735802528725 0.400125870449908 no 2017 0.41381748323517 2766 17015728
SGTC_3048 9093155 49.47 µM -0.218645588916202 0.39975087631033 no 2018 0.413463068542048 2833 25236002
SGTC_3061 glucosamine 200 µM -0.219476562294789 0.399408447943742 no 2019 0.413139417688926 2821 91431 and experimental redox chemotherapeutic
SGTC_1749 st037932 54.2 µM -0.219913010981315 0.399228626693052 no 2020 0.41296945152673 2929 594497
SGTC_713 1488-1073 324 µM -0.221535254687148 0.398560433671283 no 2021 0.412337844590278 2786 3312542
SGTC_3242 9133940 49.47 µM -0.22242985145606 0.398192081348965 no 2022 0.411989637849044 2941 17248444
SGTC_2821 7996764 71.43 µM -0.223828463637077 0.397616381371608 no 2023 0.411445390513997 3024 2987135
SGTC_681 1642-0006 26.6 µM -0.224866267966444 0.397189341953358 no 2024 0.411041655768202 2816 4446530
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.226666093535566 0.396449035752049 no 2025 0.410341697170146 2963 5377381
SGTC_1805 st050013 60.3 µM -0.227042304906098 0.396294339149095 no 2026 0.410195423226718 2866 4037144
SGTC_3189 9110682 49.47 µM -0.22713029906723 0.396258158658916 no 2027 0.410161212206056 2910 17122418
SGTC_3243 9134147 49.47 µM -0.22779370182581 0.395985416648249 no 2028 0.409903311602455 2859 24282180
SGTC_454 lyso-paf C-16 6.67 µM -0.228482352234455 0.395702348532796 no 2029 0.409635637094148 2879 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1851 st056236 18.9 µM -0.22958343127447 0.39524986694391 no 2030 0.409207741464612 2884 5393171
SGTC_2634 4'-methoxyflavone 100 µM -0.230017133378106 0.395071678487277 no 2031 0.409039228063953 2879 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_3032 9089427 49.47 µM -0.230693112954596 0.394793993006251 no 2032 0.408776612147598 2925 17173707
SGTC_1611 st001856 99.4 µM -0.233051001402619 0.39382581574247 no 2033 0.407860901256075 2851 647478
SGTC_826 1683-5028 118 µM -0.233484157720803 0.393648027704205 no 2034 0.407692734975978 2901 722377
SGTC_196 k015-0023 18.111 µM -0.233975336406636 0.393446451338598 no 2035 0.407502062981799 2809 5211998
SGTC_1516 st013856 110 µM -0.235067256108458 0.39299843735655 no 2036 0.40707826625552 2947 5281404 A mutagen and neurotoxin.
SGTC_1708 st033234 31.827 µM -0.2352286115074 0.392932245337824 no 2037 0.407015650084398 2947 674664
SGTC_1819 st053448 58.6 µM -0.236076691805565 0.392584392535931 no 2038 0.406686580024894 2845 2857616
SGTC_592 k241-0073 46.5 µM -0.238087342016118 0.391760037587133 no 2039 0.405906676049976 2944 4230158
SGTC_2710 st078562 53.7235 µM -0.238747036712198 0.391489672230362 no 2040 0.405650870594022 2793 17250908
SGTC_1572 epiandrosterone 68.9 µM -0.239051858928781 0.391364763398763 no 2041 0.405532685297744 2808 441302 A steroid.
SGTC_2882 9058044 58.44 µM -0.239709566904777 0.391095288625116 no 2042 0.405277708917523 2934 18076804
SGTC_3307 9126885 69.2785 µM -0.240211490263822 0.39088967676871 no 2043 0.405083153243069 2835 24824909
SGTC_3094 9117742 49.47 µM -0.240713465047039 0.390684074348724 no 2044 0.404888601094897 2802 17149698
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.241099460452758 0.390525996371697 no 2045 0.404739015470674 2818 23665772 A membrane-active detergent.
SGTC_2957 9076800 11.52 µM -0.241392624502365 0.390405948015672 no 2046 0.404625414280226 2880 16459615
SGTC_141 0443-0274 32.331 µM -0.241904955075083 0.39019617779477 no 2047 0.404426905277233 2955 1627241
SGTC_2465 5809242 33.21 µM -0.242019599539464 0.390149241784082 no 2048 0.404382488186587 2817 2731748
SGTC_2121 5257820 149.641 µM -0.243399759000015 0.389584323539008 no 2049 0.403847865242778 2984 791256
SGTC_1431 4049-0260 9.09 µM -0.24370379864136 0.389459907238992 no 2050 0.403730115585682 2807 3854841
SGTC_1689 st020265 53.493 µM -0.24511404802573 0.388882966320437 no 2051 0.403184062955127 2969 5758320 YPR016C TIF6
SGTC_1957 st077035 62.4 µM -0.245365709869441 0.38878003577236 no 2052 0.403086638577641 2919 705593
SGTC_3142 9086498 49.47 µM -0.245796801189696 0.388603736104304 no 2053 0.402919766697935 2977 25236367
SGTC_974 1326-0144 138 µM -0.245969982480926 0.388532918115566 no 2054 0.402852734630962 2851 5411856
SGTC_2434 5670830 169.91 µM -0.246092732450678 0.388482724948736 no 2055 0.402805224390712 2939 1549830
SGTC_3145 9085516 49.47 µM -0.246526395792892 0.388305412435501 no 2056 0.40263738696905 2936 25236195
SGTC_65 0798-0905 34.986 µM -0.246619564981237 0.388267321260659 no 2057 0.402601330747896 3242 3602145
SGTC_455 paf C-16 10 µM -0.247198091692424 0.388030821189946 no 2058 0.402377461047556 2825 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1478 0453-0656 35.7 µM -0.247443823583756 0.387930379251748 no 2059 0.40228238104158 2886 5258496
SGTC_2213 7173844 200 µM -0.247888033997727 0.387748829033386 no 2060 0.402110519251379 2853 892728
SGTC_1841 st054148 70 µM -0.248151230904338 0.387641271188789 no 2061 0.402008699201186 2933 675442
SGTC_419 nsc-638432 893 µM -0.248535055968059 0.387484432991474 no 2062 0.401860225003803 2927 368090
SGTC_132 0417-1715 25.805 µM -0.249013143640739 0.387289102985285 no 2063 0.401675307220298 2944 6769098
SGTC_1583 clindamycin 39.6 µM -0.249204281894296 0.387211018519466 no 2064 0.401601383711272 2834 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1671 st016596 74.5 µM -0.249589539869234 0.387053645460312 no 2065 0.401452394301794 2879 2829167
SGTC_3256 9138902 49.47 µM -0.25000477739322 0.386884046918856 no 2066 0.40129182705254 2837 17228773
SGTC_2557 derrustone 83.84 µM -0.250047926826933 0.386866424313814 no 2067 0.40127514265219 2967 629853 An antioxidant.
SGTC_3273 9137859 49.47 µM -0.250190613201568 0.386808151615077 no 2068 0.401219972025927 2867 2377234
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.250457966410452 0.386698972216072 no 2069 0.401116603450535 2834 364106
SGTC_462 ag-879 158 µM -0.250891291485556 0.386522033704659 no 2070 0.400949078755773 2964 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_3336 9143619 71.43 µM -0.252534469414396 0.385851293718953 no 2071 0.400313987256664 2911 45595730
SGTC_2502 avocadyne acetate 18.59 µM -0.253756533928076 0.385352671955156 no 2072 0.399841827678439 2786 3952079
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.253946563188514 0.385275153993529 no 2073 0.399768420683965 2795 6708630 An antioxidant.
SGTC_770 0389-1121 67.2 µM -0.254081399264982 0.38522015357136 no 2074 0.399716336584633 3029 6753108
SGTC_2642 cholecalciferol 100 µM -0.254183954376349 0.385178322288926 no 2075 0.399676723080102 2951 9821465 A vitamin D precursor, similar to steriods.
SGTC_319 1348-1596 45.5 µM -0.254891601084849 0.384889716175025 no 2076 0.399403411714942 3055 5380505
SGTC_1027 k015-0025 8.67 µM -0.256450035648609 0.384254350419543 no 2077 0.398801678188517 2842 3598955
SGTC_1222 0366-0074 1.18 µM -0.256545178848511 0.384215571078467 no 2078 0.398764949833271 2997 286520
SGTC_2137 5261020 140 µM -0.257141657011716 0.383972479442927 no 2079 0.398534710392338 2844 763655
SGTC_629 3448-6466 76.7 µM -0.257428354073811 0.383855653752163 no 2080 0.398424058429879 2892 573744
SGTC_2365 9042475 200 µM -0.258369904973785 0.38347205710442 no 2081 0.398060720309768 2977 6464479
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.258760862796481 0.38331281075976 no 2082 0.39790987828195 2993 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_586 0957-0265 8.15 µM -0.259187316164857 0.383139128721781 no 2083 0.397745358520137 2932 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.259998289781401 0.382808907615023 no 2084 0.397432546401258 2982 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2261 9010538 184.68 µM -0.260364513724814 0.382659812444584 no 2085 0.397291306581599 2978 6457250
SGTC_3276 9139060 49.47 µM -0.260490321806997 0.38260859812992 no 2086 0.397242789892946 2842 4870619
SGTC_2705 st078069 42.8 µM -0.260844913945196 0.38246426079591 no 2087 0.397106053370416 2947 1530061
SGTC_2657 nystatin 74.44 µM -0.261866205911245 0.382048633459496 no 2088 0.396712297223943 2925 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3122 9126309 49.47 µM -0.263655932132534 0.381320610338445 no 2089 0.396022527650017 2920 17591206
SGTC_1832 st054113 55 µM -0.263669524690446 0.38131508277364 no 2090 0.39601729025165 2984 1251267
SGTC_2206 7254556 146.969 µM -0.264165535130616 0.381113391183393 no 2091 0.395826183496155 2912 4398905
SGTC_2711 st079103 59.1 µM -0.264198354794842 0.381100046936862 no 2092 0.395813539363681 2925 54693780
SGTC_3096 9117468 49.47 µM -0.264238697331841 0.381083644136456 no 2093 0.39579799711289 3010 41316311
SGTC_1050 3232-1156 69.3 µM -0.26457637791448 0.380946355570376 no 2094 0.395667909753993 2902 700529
SGTC_910 3454-3003 490 µM -0.264855669212831 0.380832817272668 no 2095 0.395560324941012 2978 820824
SGTC_672 1441-0018 53.7 µM -0.267092242864927 0.379923969807034 no 2096 0.394699070004032 2866 251141
SGTC_3280 9140961 49.47 µM -0.268335780969012 0.379418935695995 no 2097 0.394220433274475 2847 4901226
SGTC_680 0417-1641 114 µM -0.269634496003138 0.37889171233003 no 2098 0.393720729476627 2861 2835990
SGTC_2605 digitonin 300 nM -0.270161654369483 0.378677772550643 no 2099 0.393517945759263 2998 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2192 5915882 198.485 µM -0.27042828311279 0.3785695791915 no 2100 0.393415391809909 2863 2876149
SGTC_3102 9121669 49.47 µM -0.271603071757821 0.378092983617253 no 2101 0.392963618648471 2905 41905072
SGTC_3252 9135871 49.47 µM -0.272651774207449 0.37766769611105 no 2102 0.392560454548951 3030 17682838
SGTC_1339 1486-1321 22.7 µM -0.273394105770574 0.377366742879048 no 2103 0.392275141590794 2899 3469382
SGTC_1481 3346-2004 36 µM -0.275587631411311 0.37647788777787 no 2104 0.391432405311671 2918 2770522
SGTC_3204 9114183 49.47 µM -0.276068256850139 0.376283217172916 no 2105 0.39124782047377 2838 17027248
SGTC_170 4197-0004 226 µM -0.276079233420216 0.376278771634249 no 2106 0.391243605193349 3025 218692
SGTC_796 1234-0020 70.7 µM -0.276456323886673 0.376126059012073 no 2107 0.391098800681115 2874 46495034
SGTC_1189 1431-2119 7.28 µM -0.277822162074956 0.375573089703905 no 2108 0.390574438887686 2910 3107275
SGTC_1866 st057638 64 µM -0.278284415967405 0.375386000738882 no 2109 0.390397019041933 2917 688802
SGTC_931 2812-0076 566 µM -0.278841528179795 0.375160558517236 no 2110 0.390183221507094 2872 3450959
SGTC_2839 9003951 25.97 µM -0.27976861763617 0.374785495058621 no 2111 0.389827515049372 2995 2990634
SGTC_3092 9117248 49.47 µM -0.279911382288689 0.374727748680067 no 2112 0.389772747177567 2915 17141857
SGTC_409 arachidonic acid 100 µM -0.281270190749326 0.374178269731898 no 2113 0.389251586047866 2919 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_311 1315-0136 58 µM -0.283134521498516 0.373424782163257 no 2114 0.388536859750398 3096 6759207
SGTC_1304 1165-0502 251 µM -0.284038605416714 0.373059561743517 no 2115 0.388190397817115 2930 767425
SGTC_464 bw-b 70c 158 µM -0.285411196817766 0.372505297674003 no 2116 0.387664565156851 3039 5353454
SGTC_3315 9136395 68.55 µM -0.286835967787946 0.371930242223408 no 2117 0.387118960635152 3091 16876844
SGTC_2806 7952793 58.44 µM -0.288088755509383 0.371424837261482 no 2118 0.386639399863263 3063 2972490
SGTC_2010 4012422 159 µM -0.288667737774454 0.371191336585849 no 2119 0.386417826821618 2990 952393
SGTC_864 0469-0573 172 µM -0.289850001846461 0.37071468267116 no 2120 0.38596549652815 2906 689425
SGTC_1420 4'-methoxyflavone 42 µM -0.29015604970828 0.370591325513802 no 2121 0.385848428864827 3002 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2440 5628896 157.78 µM -0.29053913432463 0.370436936291837 no 2122 0.385701908197223 2923 5522048
SGTC_1078 idebenone 36.1 µM -0.290931363403324 0.370278883324813 no 2123 0.385551906888034 2984 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2953 9074162 66.49 µM -0.291801491888055 0.369928333814351 no 2124 0.385219202249609 3039 16451992
SGTC_1356 1502-0781 85.8 µM -0.292079874407189 0.369816204377149 no 2125 0.385112776993454 2925 567702
SGTC_1509 1326-1131 80 µM -0.292386470858297 0.369692723483722 no 2126 0.384995575603001 3029 768313
SGTC_1298 1079-1278 263 µM -0.292631139754934 0.36959419338479 no 2127 0.384902054546127 2942 2840950
SGTC_1256 0570-0116 285 µM -0.292912207150638 0.369481015891085 no 2128 0.384794628967032 2943 410638
SGTC_2062 5245942 200 µM -0.293187168477786 0.369370308072855 no 2129 0.384689545720161 2905 1376160
SGTC_1674 st016616 23.6 µM -0.29344376568061 0.369267003981523 no 2130 0.384591488417005 2867 625830
SGTC_1190 1486-1332 13 µM -0.293595578996059 0.369205889534161 no 2131 0.384533477214121 2977 4150046
SGTC_527 4476-4215 268 µM -0.293929101540907 0.369071637256596 no 2132 0.384406040004454 2940 4418754
SGTC_775 4577-0580 57.3 µM -0.293946525962439 0.369064623871884 no 2133 0.384399382567916 3110 2006902
SGTC_2990 9074105 71.4286 µM -0.294409768813468 0.368878183152164 no 2134 0.384222401547018 2988 6502001
SGTC_2450 5739737 12.93 µM -0.294425183684617 0.368871979680102 no 2135 0.384216512740526 3022 2262825
SGTC_2801 7907800 81.82 µM -0.294651199715154 0.368781027012374 no 2136 0.384130172910627 3016 6620925
SGTC_665 3914-0008 307 µM -0.296940424905921 0.36786021911025 no 2137 0.383255996340203 2930 1069549
SGTC_2974 9094440 9.66 µM -0.297276633405848 0.367725047863632 no 2138 0.383127659775288 3113 25236134
SGTC_1889 st059080 5.18 µM -0.298839217937683 0.367097032416023 no 2139 0.382531362938673 3101 176925 Isolated from Daphnopsis sellowiana.
SGTC_36 0335-0881 14.2 µM -0.299360284273159 0.366887690554802 no 2140 0.382332580991133 2924 23828853
SGTC_57 miconazole 162.5 nM -0.302298139214918 0.365708130116629 no 2141 0.381212398359687 2905 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2815 7968870 71.43 µM -0.302787577111704 0.365511741834837 no 2142 0.381025875659141 2933 2977326 YHR190W ERG9
SGTC_2595 hexamethylquercetagetin 100 µM -0.302808500570003 0.365503347025875 no 2143 0.381017902433954 3011 386331
SGTC_306 1672-3436 11.6 µM -0.303273874798818 0.365316648482549 no 2144 0.380840577053439 3042 6797378
SGTC_1418 3966-3099 2.4 µM -0.30357756356096 0.365194832018644 no 2145 0.380724873511369 3034 740335
SGTC_2083 5306046 65.942 µM -0.304834666636418 0.36469072420743 no 2146 0.380246038577079 2951 539837
SGTC_2993 9054257 71.4286 µM -0.30599609607057 0.364225190059605 no 2147 0.379803809096335 2919 6470217 YGL055W OLE1
SGTC_1816 st051957 91.6 µM -0.306783407641429 0.363909726892718 no 2148 0.379504119227218 2975 674121
SGTC_1620 st003704 16.5 µM -0.30715154476563 0.363762251855446 no 2149 0.379364012785063 2976 2834414
SGTC_2462 5162487 171.77 µM -0.307327595609507 0.363691733351333 no 2150 0.379297016563189 2911 2259986
SGTC_2069 5228469 200 µM -0.307879407604588 0.363470730788855 no 2151 0.379087047773771 3057 2835210
SGTC_2243 6634756 200 µM -0.308543785084183 0.36320470565331 no 2152 0.378834294265703 3203 885676
SGTC_557 1315-0110 16.2 µM -0.309370401607713 0.36287381007382 no 2153 0.378519891426861 2939 6833801
SGTC_1265 0819-1001 68.8 µM -0.309392708548352 0.362864881996199 no 2154 0.378511408115512 2953 3106768
SGTC_2310 7668677 200 µM -0.311543064059916 0.362004579348682 no 2155 0.377693905092896 3170 2197143
SGTC_358 0075-0058 9.45 µM -0.311710328665799 0.361937690177523 no 2156 0.377630338828752 2998 1069125
SGTC_438 sphingosine 6.67 µM -0.312563542041785 0.361596555524303 no 2157 0.377306140203091 2939 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_11 0438-0307 1.3 µM -0.314045620643738 0.361004247425351 no 2158 0.376743194970207 3046 4011476
SGTC_2721 ifenprodil 61.44 µM -0.315220508936754 0.360534943621736 no 2159 0.376297117434169 3100 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2587 piperic acid 92.2 µM -0.315831767198414 0.360290862282467 no 2160 0.376065102291982 3023 5370536
SGTC_253 dyclonine 31.25 µM -0.317234895301507 0.359730795125708 no 2161 0.375532686844677 2968 3180 An oral anasthetic.
SGTC_2051 5263410 176 µM -0.318753015779271 0.359125167180458 no 2162 0.374956904552938 3050 227584
SGTC_300 r073-0011 5.04 µM -0.318796635161184 0.359107771203861 no 2163 0.374940365004915 3064 2735780
SGTC_111 0083-0039 52.457 µM -0.318942255724065 0.359049697945915 no 2164 0.374885150429889 2923 759313
SGTC_3232 9132874 49.47 µM -0.321414722179617 0.358064180214249 no 2165 0.373948063922102 2980 3784940
SGTC_3075 9116269 49.47 µM -0.321719465251549 0.357942775826208 no 2166 0.373832615046101 3179 17015205 YNL244C SUI1
SGTC_324 1315-0088 19.6 µM -0.322835717753054 0.357498202834884 no 2167 0.373409830640174 3041 6787421
SGTC_2037 5169046 200 µM -0.323212311300625 0.357348259453474 no 2168 0.373267228903404 3075 5718022
SGTC_620 0109-0052 432 µM -0.324399117268556 0.356875868425737 no 2169 0.372817943979468 3130 493037
SGTC_706 4262-0057 46.9 µM -0.32636393309024 0.356094284298085 no 2170 0.372074511055685 2993 883298
SGTC_2025 5147754 141 µM -0.327010513596293 0.355837213012839 no 2171 0.371829966653431 3058 315777 YLR208W SEC13
SGTC_2531 methyl deoxycholate 70.07 µM -0.327245968727361 0.355743615648093 no 2172 0.371740927571986 2955 16667744 Haematoxylin.
SGTC_1402 3909-7673 35.9 µM -0.328576806342599 0.355214748999672 no 2173 0.371237790686725 2928 5328014
SGTC_2947 9072639 7.68 µM -0.328759464256189 0.355142183605763 no 2174 0.371168752127849 3058 16488146
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.328872029897308 0.355097466724371 no 2175 0.37112620815924 2962 91467 include heat shock
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.329010577186471 0.355042431331331 no 2176 0.371073846638694 3060 6708739 YPR165W RHO1
SGTC_157 1348-1695 65.819 µM -0.329292342661393 0.35493051444654 no 2177 0.370967365677847 2977 5380510
SGTC_636 0kpi-0074 126 µM -0.330147715355876 0.354590838220456 no 2178 0.370644175458329 3049 616434
SGTC_862 0452-0056 10.2 µM -0.332033671436942 0.353842316764322 no 2179 0.369931916901347 3069 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1763 st044482 94.5 µM -0.332231928597458 0.353763662770216 no 2180 0.369857068081383 3120 88505
SGTC_292 k038-0015 474 µM -0.334202781873309 0.352982111727295 no 2181 0.369113272468733 3108 46368540
SGTC_989 1501-0895 10.3 µM -0.334317176846852 0.352936766870331 no 2182 0.369070115075542 3109 2830112
SGTC_2163 5671233 125 µM -0.334891719869692 0.352709056197843 no 2183 0.36885338420236 3213 701023
SGTC_925 2064-1272 59.6 µM -0.335866796301864 0.352322721488208 no 2184 0.368485658359552 3010 6815817
SGTC_1101 ebselen 5.29 µM -0.337885982726524 0.351523185006475 no 2185 0.367724555574521 3150 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3235 9132602 49.47 µM -0.338411244487013 0.351315304755379 no 2186 0.367526650806794 3116 4912240
SGTC_565 1418-0001 44.5 µM -0.338442777310162 0.351302826580229 no 2187 0.367514771190036 3162 2862145
SGTC_2199 6590217 200 µM -0.339802341355868 0.350764972217296 no 2188 0.367002692289271 3042 703109
SGTC_2403 6032726 181.2 µM -0.340509067743154 0.350485503649592 no 2189 0.366736597636636 3076 2881040
SGTC_298 1391-0729 10 µM -0.341235722014889 0.350198239144039 no 2190 0.366463066554216 2997 3237558
SGTC_1002 4049-0206 172 µM -0.342740103361634 0.349603792265798 no 2191 0.365896994969652 2998 4662749
SGTC_1310 1188-0297 994 nM -0.344348092503081 0.348968812942591 no 2192 0.365292260302556 3047 1588352
SGTC_2860 9025725 38.96 µM -0.34438067589649 0.348955950439977 no 2193 0.365280009752897 2973 40546248
SGTC_3289 9119912 71.43 µM -0.345008387260608 0.348708191263999 no 2194 0.365044032658702 3115 17014829
SGTC_1714 st033236 13.627 µM -0.3453005884875 0.348592880738394 no 2195 0.364934202149559 3208 2916566
SGTC_383 2324-0395 7.37 µM -0.346819664058036 0.347993637928649 no 2196 0.364363401611519 3146 3146421
SGTC_3175 9106517 49.47 µM -0.346916700510748 0.347955372001059 no 2197 0.364326949863732 3090 41468073
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.347359977359317 0.347780587289348 no 2198 0.364160448506388 3100 17037758
SGTC_2018 5133068 143 µM -0.34813006262004 0.347477018464606 no 2199 0.363871254032295 2966 785362
SGTC_420 mitomycin C 81.9 mM -0.348981256766225 0.347141590179288 no 2200 0.363551690482558 3015 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2722 naftopidil 47.16 µM -0.34916277130867 0.347070076603385 no 2201 0.3634835568062 3138 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2485 5633444 17.78 µM -0.350062179265094 0.346715805887438 no 2202 0.363146016909275 3097 5724239
SGTC_1885 st057546 99.9 µM -0.350981669302289 0.346353763484507 no 2203 0.362801050228413 3194 702008
SGTC_1677 st019204 53.9 µM -0.351569712216134 0.346122299487334 no 2204 0.362580491483406 3115 3945625
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.35266966935089 0.345689491437257 no 2205 0.362168050232355 3038 2724 A muscle relaxant with antifungal properties.
SGTC_2088 5278280 127.392 µM -0.352690776076544 0.345681188391662 no 2206 0.362160137591901 3121 791502
SGTC_2377 9073351 62.6 µM -0.354584149792503 0.344936668117931 no 2207 0.361450576101426 3007 7337946 YHR072W ERG7
SGTC_2099 5377090 177.372 µM -0.356207252512466 0.344298902383179 no 2208 0.360842680490673 3121 2243829
SGTC_2058 5236698 133 µM -0.356750340643373 0.344085605480462 no 2209 0.360639357764593 3049 766665
SGTC_2142 5622915 118.518 µM -0.35713090714835 0.34393616820914 no 2210 0.360496903770062 3069 5322196
SGTC_3319 9138450 16.7555 µM -0.357223263533985 0.343899906247936 no 2211 0.360462335763736 3029 2029690
SGTC_491 tetrandrine 80.3 µM -0.357706126152951 0.343710342897283 no 2212 0.36028162402922 3109 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_142 0335-0849 62.6745 µM -0.357904678302898 0.343632406221035 no 2213 0.360207324776194 3163 3889043 YPR107C YTH1
SGTC_537 1334-0398 209 µM -0.358513884409766 0.343393319105909 no 2214 0.359979389627244 3195 5846986
SGTC_1872 amphotericin b 148 nM -0.358776716076154 0.343290188356687 no 2215 0.359881066230344 3138 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_940 3232-1287 54.8 µM -0.359053385947459 0.343181640333671 no 2216 0.359777576078989 3113 1585493 YIL048W NEO1
SGTC_1158 4092-0494 91.8 µM -0.359796948962632 0.342889976655096 no 2217 0.35949949249278 3170 1148199
SGTC_363 0455-0021 3.06 µM -0.359859021114778 0.342865632993605 no 2218 0.359476281619843 3013 4597466
SGTC_1400 3771-8998 51.5 µM -0.360069705924372 0.342783010795102 no 2219 0.359397503324671 3026 670767
SGTC_1690 st023502 41.2 µM -0.362705827536007 0.341749865543288 no 2220 0.358412323009442 3140 24207482
SGTC_3017 9080681 49.47 µM -0.364947607792984 0.340872201308054 no 2221 0.357575257837116 3111 16451914
SGTC_3214 9129694 49.47 µM -0.365257397867972 0.340750985061436 no 2222 0.357459638128071 3202 17158655
SGTC_2151 5563267 85.4165 µM -0.365645613120506 0.34059910542342 no 2223 0.357314767080406 3073 5310824
SGTC_3055 9094636 49.47 µM -0.367353053976424 0.339931418384636 no 2224 0.35667784238315 3231 25236176
SGTC_1910 st062352 60.4 µM -0.367952079631509 0.339697290900403 no 2225 0.356454483085302 2978 2245730
SGTC_1904 st060225 78 µM -0.368460413008277 0.33949865873361 no 2226 0.35626497891647 3100 66595
SGTC_1192 1488-0095 21.4 µM -0.368692462712255 0.339407999716924 no 2227 0.356178483730437 3125 915875
SGTC_1952 st077036 64.1 µM -0.368695779306321 0.339406704031033 no 2228 0.356177247542795 3043 2937007
SGTC_2127 5253358 187.912 µM -0.368761458491402 0.339381045691569 no 2229 0.356152767379526 2979 20612
SGTC_992 3909-8734 162 µM -0.369256518993286 0.339187668500822 no 2230 0.355968265874233 3081 4288319
SGTC_1865 st057639 52.2 µM -0.370091947464335 0.338861435131287 no 2231 0.355656990908874 3033 688818
SGTC_2027 5150920 200 µM -0.370153830982339 0.338837274528387 no 2232 0.355633937356669 3100 786715
SGTC_1839 st053978 48 µM -0.370168999442155 0.338831352549721 no 2233 0.355628286710019 3146 3788398
SGTC_1195 1502-0147 41.1 µM -0.371605670760699 0.338270636738083 no 2234 0.355093233169649 3070 817940
SGTC_1287 0971-0001 34.6 µM -0.37222071688399 0.338030701025159 no 2235 0.354864261334916 3098 4665869
SGTC_970 1315-0089 19.5 µM -0.372294105333475 0.338002075839838 no 2236 0.354836943487617 3114 6811083 YLR033W RSC58
SGTC_1846 st056244 14.8 µM -0.372450793121296 0.337940962859245 no 2237 0.354778621098164 3103 5393182
SGTC_1234 0326-0494 15.5 µM -0.373074803457409 0.337697622328353 no 2238 0.354546385507494 3188 1547813
SGTC_731 3966-0296 387 µM -0.374398057976657 0.337181827444377 no 2239 0.354054093786218 3050 660956
SGTC_2735 sertaconazole 140 nM -0.37531269995981 0.336825485451721 no 2240 0.353713961073583 3111 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_332 4112-0506 40.9 µM -0.375563107415782 0.336727952915904 no 2241 0.35362086108424 3067 2790355
SGTC_2107 5363541 170.161 µM -0.375582223012686 0.336720507931116 no 2242 0.353613754379649 3170 244052
SGTC_544 k015-0020 52.4 µM -0.376759588798095 0.336262080672812 no 2243 0.353176137432121 3112 3008304
SGTC_748 act1.228 77.9 µM -0.379113173821799 0.335346402605845 no 2244 0.352301911975876 3058 4421505 YNR035C ARC35
SGTC_156 3474-0145 5.642 µM -0.379444542009068 0.335217559950225 no 2245 0.352178889712473 3188 2265471
SGTC_433 pimozide 108 µM -0.381319949536844 0.334488729221368 no 2246 0.351482926169667 3020 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2912 7964298 10.93 µM -0.381881338081968 0.334270680550516 no 2247 0.351274691598662 3158 2975850
SGTC_952 1185-0122 232 µM -0.38287095670938 0.333886439415107 no 2248 0.350907723354192 3038 678600
SGTC_2085 5307070 144.047 µM -0.383117331792883 0.333790805937656 no 2249 0.350816384678246 3058 2840351
SGTC_2895 9054447 58.44 µM -0.383916479075739 0.333480681551742 no 2250 0.35052017603007 3095 2697450
SGTC_47 0149-0135 24.25 µM -0.386052616126505 0.33265227169365 no 2251 0.349728850746325 3067 5239155
SGTC_3229 9132204 49.47 µM -0.387842169562944 0.331958897817662 no 2252 0.349066418288783 3078 17682924
SGTC_1523 st012844 44.7 µM -0.387945538278661 0.331918864496445 no 2253 0.349028168692489 3216 4274103
SGTC_2942 9052777 62.25 µM -0.390546626334749 0.330912130560716 no 2254 0.348066192126308 3103 6469503
SGTC_1755 st041960 45.185 µM -0.390620005574416 0.330883747294243 no 2255 0.348039067965849 3203 2257073
SGTC_2506 ethyl hematommate 54.16 µM -0.390622869160544 0.330882639671945 no 2256 0.348038009475553 3161 3940691 An allergen.
SGTC_727 3032-0951 202 µM -0.394436264993812 0.329408952187375 no 2257 0.346629486936018 3135 3652836
SGTC_211 3455-0679 143.504 µM -0.3945085883533 0.329381028308608 no 2258 0.346602793855185 3190 748649
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.396841836340029 0.328480678032834 no 2259 0.345742048763163 3158 5379071
SGTC_109 0132-0036 33.701 µM -0.39877353431887 0.327736029844094 no 2260 0.345030039774706 3031 67274 A color developer.
SGTC_248 streptozotocin 5.23457 mM -0.399655945124776 0.327396097827185 no 2261 0.344704972243451 3193 5300 DNA alkylating agent.
SGTC_2514 salinomycin 42.74 µM -0.399842914145031 0.327324089919755 no 2262 0.344636110236809 3263 23682228 A polyether potassium ionophore.
SGTC_900 1112-0045 141 µM -0.400716542687331 0.326987712075594 no 2263 0.344314414949082 3139 56211 YIL048W NEO1
SGTC_603 3794-0023 45.9 µM -0.40172185464804 0.326600805355338 no 2264 0.343944369368148 3203 3802260
SGTC_3152 9099253 49.47 µM -0.403870638897993 0.325774444719965 no 2265 0.3431539241188 3149 25236131
SGTC_2898 9056270 58.44 µM -0.404045938261123 0.325707067305591 no 2266 0.3430894692368 3183 19154699
SGTC_701 4424-0219 185 µM -0.404722606442376 0.325447039047006 no 2267 0.342840711581002 3288 2911779
SGTC_547 1120-0019 610 nM -0.404850577965856 0.325397872035752 no 2268 0.342793674175827 3107 3676939
SGTC_1789 tunicamycin 25 nM -0.405744355319581 0.325054565079773 no 2269 0.342465224011434 3233 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2572 astragaloside iv 100 µM -0.406574521138639 0.324735824805979 no 2270 0.342160256832422 3262 45006101 An anti-inflammatory agent.
SGTC_1924 st058459 75.1 µM -0.409204806045868 0.323726780988511 no 2271 0.341194683852504 3206 688683
SGTC_3097 9117246 49.47 µM -0.409444512599835 0.323634887738694 no 2272 0.34110673955687 3155 16423892
SGTC_226 1,3-diallylurea 8.28947 mM -0.410339070182503 0.323292047564898 no 2273 0.340778617693599 3198 74537 YKL182W FAS1
SGTC_1239 0337-0584 35.4 µM -0.411064183177189 0.323014257274535 no 2274 0.340512736110604 3294 914301 YML130C ERO1
SGTC_1065 prochlorperazine maleate 2.48 µM -0.411175363182142 0.322971673013462 no 2275 0.340471976066658 3205 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2242 6630449 61.2675 µM -0.411823873256323 0.322723326386979 no 2276 0.340234260937 3243 691249 YDR170C SEC7
SGTC_2399 5884133 200 µM -0.412720467783065 0.322380106145733 no 2277 0.339905713578005 3130 722445
SGTC_3169 9102970 49.47 µM -0.412923982164186 0.322302221031206 no 2278 0.339831154855091 3223 17027839
SGTC_2316 5844804 197.44 µM -0.414359605225443 0.321753028706036 no 2279 0.339305383805073 3222 776813
SGTC_3220 9131269 49.47 µM -0.414676432536909 0.321631879966823 no 2280 0.339189393601451 3232 17722206
SGTC_1514 1189-1591 158 µM -0.415031337541217 0.321496193563237 no 2281 0.339059481282972 3300 767698 YMR146C TIF34
SGTC_101 0490-5701 117.494 µM -0.415038514565198 0.321493449906769 no 2282 0.339056854343994 3211 4661669
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.415480836078434 0.321324376574758 no 2283 0.338894970642691 3094 15053
SGTC_1608 st001473 40.5 µM -0.416188462053405 0.321053970045364 no 2284 0.338636050964181 3141 7292267
SGTC_2234 tolnaftate 200 µM -0.41645654630998 0.320951551242774 no 2285 0.338537979094706 3172 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_841 0251-0215 91.2 µM -0.419568464365812 0.319763673820348 no 2286 0.337400364987561 3208 3888614
SGTC_1436 4092-1007 8.32 µM -0.421448669135966 0.319046858272263 no 2287 0.336713743216948 3149 2881121
SGTC_331 k048-0133 24.5 µM -0.421459176265012 0.319042854396705 no 2288 0.33670990770183 3131 6813582
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.421917606332551 0.318868184332465 no 2289 0.336542579248785 3215 75037 A free radical scavenger.
SGTC_674 0498-0004 451 µM -0.423758556950052 0.31816715459739 no 2290 0.335870952544685 3209 4231473
SGTC_633 0437-0093 97.7 µM -0.42445380400906 0.317902575298567 no 2291 0.335617444467015 3167 2831118
SGTC_2904 7225135 42.03 µM -0.425319370657805 0.317573310011149 no 2292 0.335301937263785 3266 4446116
SGTC_2732 terfenadine 20 µM -0.427411801690769 0.316777936485591 no 2293 0.334539706496796 3190 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_122 0236-0016 402.397 µM -0.427888178100844 0.316596974717482 no 2294 0.334366267224706 3204 6808838
SGTC_70 0141-0289 43.283 µM -0.428257872370982 0.316456568686005 no 2295 0.334231693179193 3188 352408
SGTC_1388 3346-4487 254 µM -0.42905742009224 0.31615299927254 no 2296 0.333940719161884 3232 3345614
SGTC_2276 7947513 42.08 µM -0.42984256345586 0.315855019408114 no 2297 0.333655084345811 3208 2105100
SGTC_951 1171-0579 82.7 µM -0.430875342677846 0.315463238260374 no 2298 0.333279506509239 3188 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3250 9135583 49.47 µM -0.431405370761388 0.315262254467037 no 2299 0.333086822720176 3275 7699353
SGTC_1843 st055809 45.5 µM -0.431570585532299 0.315199617088196 no 2300 0.333026770363222 3265 16413835
SGTC_2427 5545055 42.75 µM -0.431734040269378 0.31513765221346 no 2301 0.332967361957855 3150 5372858
SGTC_905 2-aminofluorene 215 µM -0.433307010853813 0.314541612994038 no 2302 0.332395872759203 3181 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2005 4024620 188 µM -0.43373672488607 0.31437886717501 no 2303 0.332239817401437 3183 236743
SGTC_1786 berberine 21.6 µM -0.434621977089201 0.314043708871031 no 2304 0.331918420065099 3216 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2460 5552655 174.22 µM -0.436110778191579 0.313480391557298 no 2305 0.331378178762544 3281 5401989
SGTC_460 trequinsin 123 µM -0.436747634844171 0.313239556944244 no 2306 0.331147189593531 3258 5537 A vasodilator.
SGTC_1046 2001-0062 216 µM -0.437433449259763 0.312980297442801 no 2307 0.330898515186161 3168 739778
SGTC_2203 7227154 166.4 µM -0.438658488822792 0.312517423935407 no 2308 0.330454504913151 3229 896304
SGTC_2756 carbadox 75.1 µM -0.438771379818847 0.312474783646356 no 2309 0.330413600057092 3181 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2305 7443522 69.23 µM -0.441330742253881 0.311508756181939 no 2310 0.329486786670631 3189 5415886
SGTC_772 k072-0172 35.3 µM -0.442154063499265 0.311198270045501 no 2311 0.32918886228109 3181 5861980
SGTC_1776 st049249 45.9 µM -0.44338435630658 0.310734559458111 no 2312 0.328743874597598 3238 1822314
SGTC_2283 7944793 200 µM -0.444755388887978 0.310218156532028 no 2313 0.328248268317184 3237 2970533
SGTC_1097 itavastatin 7.23 µM -0.447256899785998 0.309276920235639 no 2314 0.327344791270295 3207 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1340 1486-1359 257 µM -0.449013852627337 0.308616583600879 no 2315 0.326710831845474 3204 4309068
SGTC_2688 kanamycin b 96.69 µM -0.449490537456742 0.308437531998039 no 2316 0.326538916319284 3378 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_348 k064-0012 10.7 µM -0.451117249878192 0.307826852014885 no 2317 0.325952522905856 3177 5066323
SGTC_519 k048-0011 62.8 µM -0.451959160671803 0.307511001192988 no 2318 0.325649201760263 3261 6836379
SGTC_3070 9117005 49.47 µM -0.453747972229387 0.306840385340141 no 2319 0.325005117260371 3293 8779016
SGTC_381 3461-2219 42.7 µM -0.454740603454381 0.306468531716893 no 2320 0.32464793302357 3283 2883159
SGTC_1710 st031758 61.5 µM -0.455322933329438 0.306250475427955 no 2321 0.324438464897848 3355 5394341
SGTC_897 1000-0139 31.4 µM -0.457541983134449 0.305420170701514 no 2322 0.323640766660392 3331 6151020
SGTC_1783 st039459 87.517 µM -0.457610780289337 0.305394444741372 no 2323 0.323616048559996 3373 729761
SGTC_1060 3448-7350 82 µM -0.458984789151774 0.304880850223953 no 2324 0.323122544592782 3324 570178
SGTC_177 1327-0068 8.361 µM -0.460771268701883 0.304213651723703 no 2325 0.322481358525294 3308 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_768 0384-0033 77.3 µM -0.461160910501387 0.30406821821025 no 2326 0.32234158206306 3205 3965305 YMR134W ERG29
SGTC_1248 0469-0687 58.6 µM -0.462206289855786 0.303678184327129 no 2327 0.321966696552299 3287 4017482
SGTC_663 1486-0733 13.9 µM -0.463587515567913 0.303163188004813 no 2328 0.321471650291581 3201 722445 YPR165W RHO1
SGTC_2516 gossypol 71.55 µM -0.464544486410974 0.302806606264571 no 2329 0.321128847361499 3350 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_84 0443-0269 128.823 µM -0.464676857812547 0.302757297477773 no 2330 0.321081441705433 3322 6150058
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.467815805140497 0.301589084622075 no 2331 0.319958158508905 3250 4620898
SGTC_990 3985-0011 41.3 µM -0.468212849262254 0.30144146244225 no 2332 0.319816192143121 3242 5399565 YGL099W LSG1
SGTC_2770 toltrazuril 17.5 µM -0.468711573618157 0.301256081346366 no 2333 0.319637906573745 3335 68591 Kills coccidiodes.
SGTC_942 3253-1115 227 µM -0.469423810474817 0.300991424470599 no 2334 0.319383366134453 3384 46497897
SGTC_2971 9092186 9.93 µM -0.469750487080887 0.30087007126033 no 2335 0.319266646341835 3177 25236400
SGTC_2853 9015042 58.44 µM -0.470352755718852 0.300646399506798 no 2336 0.319051505954397 3127 6457456
SGTC_1530 rhein 70.4 µM -0.470518930487977 0.300584698397121 no 2337 0.318992156282947 3287 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1480 1070-0044 41.2 µM -0.470613365125797 0.300549637126512 no 2338 0.31895843081934 3290 3124987
SGTC_1567 st069303 68.4 µM -0.470981354800913 0.300413029185988 no 2339 0.318827024885142 3314 5581319
SGTC_2988 9073640 71.4286 µM -0.47275015442944 0.299756793710428 no 2340 0.318195719863492 3405 9102229
SGTC_587 k089-0003 57 µM -0.473130799526863 0.299615656981786 no 2341 0.318059932174863 3312 9659696
SGTC_1409 3909-8004 61.9 µM -0.475111140056612 0.298881866714884 no 2342 0.317353879329313 3276 2119279
SGTC_597 k018-0003 82.8 µM -0.478337469552831 0.297688142944873 no 2343 0.316205015806812 3355 6786234
SGTC_98 0074-0023 107.663 µM -0.478581093754894 0.297598091762441 no 2344 0.316118335500946 3296 3563821
SGTC_1956 st077085 54 µM -0.478906885474654 0.297477688311051 no 2345 0.316002436185915 3261 24208685
SGTC_3284 9108171 64.8615 µM -0.480852409776619 0.29675914078052 no 2346 0.315310699140644 3287 8687505
SGTC_510 ag-490 170 µM -0.481482449493556 0.296526616375226 no 2347 0.315086825169081 3386 5328779
SGTC_3320 9137005 35.139 µM -0.481957149013125 0.296351477466483 no 2348 0.314918193562891 3277 4908713
SGTC_1185 1319-0113 81.3 µM -0.482144834511824 0.296282244571649 no 2349 0.314851531063347 3337 4672763
SGTC_2211 7117706 200 µM -0.484868868289038 0.295278246884795 no 2350 0.313884683485523 3319 822771
SGTC_1473 k844-0725 134 µM -0.484986144001009 0.295235057730464 no 2351 0.313843087161506 3348 54682906
SGTC_2301 7769476 200 µM -0.485032673396797 0.295217923144563 no 2352 0.313826584384275 3290 977820
SGTC_1159 4092-0538 61.2 µM -0.485645874982502 0.294992152652824 no 2353 0.31360913239608 3288 717301
SGTC_1365 1672-3266 55.4 µM -0.486419493916143 0.294707432734817 no 2354 0.313334885993675 3360 6415873
SGTC_1149 3909-7961 23.3 µM -0.487004261511663 0.294492301121088 no 2355 0.313127655488427 3293 735261
SGTC_340 k038-0059 454 µM -0.488012914679947 0.294121395613997 no 2356 0.312770346705561 3334 23733424
SGTC_322 k048-0136 19.3 µM -0.488377711065197 0.293987304576454 no 2357 0.312641163256473 3328 6823282
SGTC_2381 9035592 200 µM -0.48879622238887 0.293833503945695 no 2358 0.312492986361471 3303 4749657
SGTC_980 1473-0395 201 µM -0.488982036712051 0.293765230128288 no 2359 0.312427207200352 3244 768876
SGTC_1063 disulfiram 1.84 µM -0.49058253389087 0.293177463073509 no 2360 0.311860871145278 3303 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_412 gemfibrozil 100 µM -0.490612149724669 0.29316659208614 no 2361 0.311850395765354 3347 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1393 3470-5649 58.2 µM -0.49093143548846 0.293049404775325 no 2362 0.311737471260092 3296 4108395
SGTC_1778 st046819 58.9 µM -0.491008974080823 0.293020949100147 no 2363 0.311710050198922 3265 671715
SGTC_2862 9027634 71.43 µM -0.491366486850231 0.292889763054311 no 2364 0.31158363144383 3206 5012562
SGTC_2907 7721985 69.9 µM -0.493387130085401 0.292148819426016 no 2365 0.310869537126929 3324 3267881
SGTC_1741 st038134 10.228 µM -0.495317151799321 0.291441921052987 no 2366 0.310188132795096 3475 1272587
SGTC_1136 pergolide 1.05886 µM -0.495456589193734 0.291390881010601 no 2367 0.31013892888443 3222 47811 A dopamine receptor agonist.
SGTC_2614 arthonioic acid 13.39 µM -0.497343022365244 0.290700776133087 no 2368 0.309473588952654 3328 6710684
SGTC_1235 benzylparaben 21.5 µM -0.497767638333834 0.290545546348332 no 2369 0.309323913999343 3344 7180
SGTC_2294 7971431 200 µM -0.498551034197669 0.290259256766525 no 2370 0.309047854001144 3332 5741572
SGTC_2727 riluzole 51.77 µM -0.499557779992024 0.28989153878376 no 2371 0.308693246266135 3335 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_469 w7 172 µM -0.500308823647259 0.289617359415853 no 2372 0.308428821023296 3356 45115570 A P450 inhibitor.
SGTC_1694 st024011 44.9 µM -0.500868743962407 0.289413031634664 no 2373 0.30823175055517 3378 2787533
SGTC_1135 dihydrocapsaicin 536.708 nM -0.501722387442103 0.289101647917049 no 2374 0.307931407163936 3287 107982 A Capsaicinoid.
SGTC_2060 5238662 140 µM -0.503580575016367 0.288424381734411 no 2375 0.307278072844631 3325 790130
SGTC_3052 9092717 49.47 µM -0.504859194127759 0.287958789573905 no 2376 0.306828868216735 3399 25237534
SGTC_1406 3909-7906 11.9 µM -0.50545432547823 0.287742201483161 no 2377 0.306619885423806 3359 X1406
SGTC_2227 7312221 64.1025 µM -0.505705550941896 0.287650795290806 no 2378 0.306531685444761 3349 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2644 guaiazulene 100 µM -0.50576960410459 0.287627492302273 no 2379 0.306509199518283 3363 3515 A coloring agent.
SGTC_161 4065-0411 162.148 µM -0.507116030069269 0.287137859752226 no 2380 0.306036704041304 3333 1906281 YLR208W SEC13
SGTC_3173 9105693 49.47 µM -0.507166027735407 0.287119685525974 no 2381 0.306019164781559 3458 17096658
SGTC_697 0508-1955 564 µM -0.507443542273661 0.287018818479854 no 2382 0.305921820332097 3427 6243113
SGTC_2838 9002687 71.43 µM -0.509866886171074 0.286138729787163 no 2383 0.305072361173384 3257 6457060
SGTC_2537 larixol 68.93 µM -0.510933995647467 0.285751593325304 no 2384 0.304698637764729 3400 6708759
SGTC_575 k072-0246 11.9 µM -0.512178517683863 0.285300408356573 no 2385 0.304263038219974 3355 6796779
SGTC_2260 7964312 200 µM -0.512400878720732 0.285219830059019 no 2386 0.304185238062837 3419 231951
SGTC_798 1287-0182 476 µM -0.512761418101182 0.285089202300771 no 2387 0.304059110608868 3421 1649755
SGTC_1030 k029-0042 36.7 µM -0.512784581676463 0.285080810833695 no 2388 0.30405100809469 3342 6080581
SGTC_173 1273-0061 2.693 µM -0.513564783550983 0.284798235946769 no 2389 0.303778153230624 3366 2847414 YPL266W DIM1
SGTC_3263 9137018 49.47 µM -0.513713299458648 0.284744461340456 no 2390 0.303726226120416 3336 43844957
SGTC_1988 st071872 53.4 µM -0.514034665918177 0.284628117636222 no 2391 0.303613877095565 3412 16414116
SGTC_2728 chlorpromazine 9.18 µM -0.514164563455433 0.28458109751336 no 2392 0.303568470461275 3343 2726 A thorazine and dopamine antagonist.
SGTC_1341 1486-1360 280 µM -0.514198544587343 0.284568797684451 no 2393 0.303556592608458 3273 3976547
SGTC_2155 5570423 76 µM -0.516615258517729 0.283694694327914 no 2394 0.302712381014098 3291 797402
SGTC_711 k292-0785 179 µM -0.517339388622836 0.283433033689395 no 2395 0.302459631293192 3351 4146315
SGTC_198 3454-2873 16.191 µM -0.518514313789368 0.283008726904116 no 2396 0.302049737924465 3319 710957
SGTC_2201 6605497 169.863 µM -0.519809705620659 0.282541269079399 no 2397 0.301598106994189 3351 670741
SGTC_1734 st037168 69.4 µM -0.520666836603167 0.282232167201854 no 2398 0.301299440286869 3347 708907
SGTC_2066 5222451 176 µM -0.522135681216942 0.28170284552022 no 2399 0.300787932321086 3342 2281147
SGTC_2596 sinensetin 100 µM -0.522200464125893 0.281679510985631 no 2400 0.30076538145356 3307 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2972 9093619 59.92 µM -0.522255584088072 0.281659657738133 no 2401 0.300746194849071 3256 25236256
SGTC_2445 5742597 35.57 µM -0.525006731302796 0.280669600800061 no 2402 0.299789255784631 3281 1774255
SGTC_3134 9127454 49.47 µM -0.525180337370462 0.280607181596382 no 2403 0.299728916184331 3460 24262820
SGTC_89 0302-0250 142.109 µM -0.525346820918833 0.280547329568869 no 2404 0.299671057298207 3443 4203518 YLR208W SEC13
SGTC_2918 7977171 22.06 µM -0.525505940709437 0.280490130639763 no 2405 0.29961576230621 3363 2236483
SGTC_1993 st073995 70.8 µM -0.526563676274533 0.280110049061639 no 2406 0.299248311016114 3343 3098394
SGTC_457 grayanotoxin iii 135 µM -0.528674558197914 0.279352281902048 no 2407 0.298515614578839 3402 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2743 auranofin 4.32 µM -0.529036031855798 0.279222619557463 no 2408 0.298390227363576 3315 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.531244947111089 0.278430907144902 no 2409 0.297624524880775 3399 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1264 0783-0040 158 µM -0.532133541938464 0.278112728610255 no 2410 0.297316753854224 3315 2855798
SGTC_2364 9055074 200 µM -0.534770273421743 0.277169641256242 no 2411 0.296404360555948 3392 6470630
SGTC_581 0958-0271 211 µM -0.535101085923024 0.277051429154836 no 2412 0.296289979539351 3356 4591145
SGTC_3007 9078383 71.4286 µM -0.536022986954922 0.276722128521739 no 2413 0.295971331881591 3323 6496995
SGTC_1602 st001878 87.6 µM -0.536590167913297 0.276519628299311 no 2414 0.295775368563694 3459 595405 YLR310C CDC25
SGTC_1408 3909-7976 48.8 µM -0.539860273809616 0.275353523651519 no 2415 0.29464669813895 3400 24152374
SGTC_2969 9091408 28.7 µM -0.540712839407429 0.275049900883941 no 2416 0.294352763678895 3293 4286311
SGTC_346 4513-0042 7.16 µM -0.541142336379658 0.274897007331289 no 2417 0.294204739619274 3393 2827372
SGTC_342 k048-0088 23.3 µM -0.541290909158216 0.274844127723388 no 2418 0.294153542734843 3329 6820570
SGTC_1564 D-Arginine 115 µM -0.541291394870339 0.274843954858309 no 2419 0.29415337536943 3361 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3021 9087658 49.47 µM -0.542128866632111 0.274545978158775 no 2420 0.293864867010551 3440 25237042
SGTC_1311 1190-0148 100 µM -0.543077434550938 0.274208665497566 no 2421 0.293538244290268 3459 1961333
SGTC_3216 9129716 49.47 µM -0.543077870695466 0.274208510450784 no 2422 0.293538094150225 3343 8056934
SGTC_187 1488-2104 32.728 µM -0.543319793209161 0.274122515111208 no 2423 0.293454819310195 3410 2852859
SGTC_598 3937-0236 20.2 µM -0.546043834607817 0.273155130391799 no 2424 0.292517902987306 3430 1379313
SGTC_479 n-linoleoylglycine 10 µM -0.547305999344018 0.272707473945017 no 2425 0.292084261442922 3395 6433346 An anti-infammatory.
SGTC_2409 alverine citrate 63.97 µM -0.547586017827234 0.272608208160346 no 2426 0.291988096150126 3517 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_534 k292-0788 63.4 µM -0.547748553383323 0.272550597979091 no 2427 0.291932284171186 3478 4146317
SGTC_2629 bisabolol 100 µM -0.548476946489936 0.272292495754219 no 2428 0.291682227258655 3465 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3346 9158254 43.5805 µM -0.549180633526388 0.272043263382709 no 2429 0.29144074677934 3412 17639500
SGTC_125 0133-0007 11.75 µM -0.549225532606878 0.272027364845323 no 2430 0.291425342170054 3495 26541
SGTC_121 0557-0495 61.343 µM -0.55030442222042 0.271645474486717 no 2431 0.291055295799586 3426 3104427
SGTC_1100 amiodarone 5.07 µM -0.551218942776247 0.271321974357722 no 2432 0.290741798052942 3460 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_446 go6976 132 µM -0.551877546505017 0.27108912056685 no 2433 0.290516126473801 3429 3501 A protein kinase C inhibitor.
SGTC_927 2425-1185 123 µM -0.552476283290452 0.270877519661343 no 2434 0.290311039559402 3332 730375
SGTC_2258 7960471 200 µM -0.552538401556561 0.270855571026518 no 2435 0.290289765906142 3397 2974708
SGTC_2119 5528445 120.635 µM -0.553355949106442 0.270566784587242 no 2436 0.290009848320129 3463 791935
SGTC_1188 1403-0014 4.57 µM -0.555235541309114 0.269903430607256 no 2437 0.289366780883365 3398 9614867
SGTC_1945 st075991 56.6 µM -0.555336848345377 0.269867700015802 no 2438 0.289332139606088 3371 1084980
SGTC_1109 tnp00067 928.257 nM -0.558178277025045 0.268866504986474 no 2439 0.288361326471173 3398 676295
SGTC_1098 clofazimine 15.1 µM -0.558693170857044 0.268685278773931 no 2440 0.288185570420423 3502 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1252 0493-0875 34.8 µM -0.558778978254681 0.268655083273175 no 2441 0.288156285471705 3400 3960963
SGTC_110 0850-0284 111.64 µM -0.559307495832737 0.268469136295997 no 2442 0.287975940260649 3369 3906265
SGTC_354 2783-3500 4.88 µM -0.559334856018935 0.26845951199409 no 2443 0.287966605638718 3372 6740761
SGTC_1214 0358-0031 63.7 µM -0.55990308136322 0.26825967054801 no 2444 0.28777277343889 3516 4301366
SGTC_1488 4013-0813 75.9 µM -0.560370935127518 0.268095185382519 no 2445 0.287613226127054 3377 2910057
SGTC_827 3253-0474 693 µM -0.560524258236032 0.268041292028063 no 2446 0.28756094903698 3483 5402065
SGTC_1497 4476-2978 41.3 µM -0.561679915738591 0.267635251855961 no 2447 0.287167060337829 3467 1528379
SGTC_1012 4112-3522 18 µM -0.562570355976145 0.267322607362054 no 2448 0.286863741324968 3480 3112398
SGTC_2304 7443016 91.4 µM -0.563667408916014 0.266937672141032 no 2449 0.28649025077142 3425 939854
SGTC_1290 0986-0249 10.2 µM -0.563711663229099 0.266922150012872 no 2450 0.286475189278367 3414 53329
SGTC_2071 5230951 39.92 µM -0.564067174047585 0.266797471718763 no 2451 0.286354208520688 3510 1799272
SGTC_1223 0764-0573 147 µM -0.564421343573809 0.266673293088072 no 2452 0.286233708327328 3468 1609797
SGTC_3074 9116018 49.47 µM -0.564941031934115 0.266491133285969 no 2453 0.28605693675239 3425 17027303
SGTC_120 rhodamine 6G 52.259 µM -0.565379713064854 0.266337416927571 no 2454 0.285907760108459 3396 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1181 1222-0449 220 µM -0.565397037558324 0.266331347247821 no 2455 0.285901869550241 3533 658318
SGTC_1171 0368-0077 21.4 µM -0.566111985604816 0.266080924472605 no 2456 0.285658828041545 3404 3239779
SGTC_1035 k081-0041 55.2 µM -0.566591467915554 0.265913044426654 no 2457 0.285495886528022 3511 731709
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.567865346290962 0.265467285162652 no 2458 0.285063202059227 3380 88881 An O-methylated flavonoid and antioxidant.
SGTC_3212 9128307 49.47 µM -0.569561302238123 0.264874420218577 no 2459 0.284487640721231 3266 27243542
SGTC_3295 9122362 53.5725 µM -0.571418261038754 0.264226045334791 no 2460 0.283858076763274 3455 4730473
SGTC_1512 0259-0544 12.2 µM -0.57264558275473 0.263797958333967 no 2461 0.283442344783894 3472 18476
SGTC_2251 lansoprazole 556 µM -0.57301692710677 0.263668504002161 no 2462 0.283316616456877 3325 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1292 0kpi-0043 232 µM -0.574958621251411 0.262992138264982 no 2463 0.282659641092645 3437 3333905
SGTC_981 1488-1094 54.9 µM -0.574993871721771 0.262979867390173 no 2464 0.282647720808519 3454 3449522
SGTC_1329 1447-1697 50.6 µM -0.575537867867173 0.26279053657585 no 2465 0.282463793942879 3466 2840515
SGTC_2406 ethylparaben 405.7 µM -0.575912588741954 0.262660160390018 no 2466 0.282337133084446 3231 8434 A possible steroid mimic.
SGTC_1884 5633444 25 µM -0.575993611082281 0.262631974736202 no 2467 0.282309750001743 3509 5724239
SGTC_661 1304-0007 33.6 µM -0.57615094742957 0.262577245761541 no 2468 0.282256578759871 3444 3117130
SGTC_1610 st001799 48.1 µM -0.576963957529671 0.262294535680672 no 2469 0.281981901795241 3390 621897
SGTC_400 oxethazaine 37.5 µM -0.577263520689976 0.262190407137746 no 2470 0.281880726297382 3452 4621 A local anesthetic.
SGTC_2944 9067346 25.62 µM -0.57827296956016 0.261839677406854 no 2471 0.28153992038144 3466 6473075
SGTC_1007 4101-0031 70 µM -0.57835058978494 0.261812718478398 no 2472 0.281513722796433 3499 1146276
SGTC_1094 duloxetine 25.4 µM -0.579469970349826 0.261424095446617 no 2473 0.281136051730768 3461 60834 A selective serotonin reuptake inhibitor.
SGTC_3042 9091578 49.47 µM -0.57973385199664 0.261332525011473 no 2474 0.28104705559306 3468 25236497
SGTC_1152 3909-8331 15.9 µM -0.582220275132683 0.26047051290973 no 2475 0.280209159090866 3444 16001939
SGTC_963 1269-2853 151 µM -0.583582624741055 0.259998824881596 no 2476 0.279750576454778 3433 3668223
SGTC_2664 lyso-paf C-16 73.48 µM -0.584185798867802 0.259790127915285 no 2477 0.279547657432818 3467 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2744 captopril 92.04 µM -0.584932380311844 0.25953193208327 no 2478 0.27929659252587 3461 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_344 k064-0035 6.43 µM -0.585648296191595 0.259284466069884 no 2479 0.279055942973321 3398 5088750
SGTC_555 4296-0685 37 µM -0.587118675938651 0.258776592077345 no 2480 0.278562002708202 3460 2908540 YHR072W ERG7
SGTC_2319 6033012 152.6 µM -0.587710421613708 0.258572346563461 no 2481 0.278363339599143 3387 847246
SGTC_987 1497-1013 404 µM -0.588354702427922 0.258350063108997 no 2482 0.278147117744271 3498 1676435
SGTC_1729 st035615 45.989 µM -0.589319315502765 0.258017446951622 no 2483 0.277823544987998 3441 17385451
SGTC_2458 5808907 16.39 µM -0.59115336719697 0.257385645699475 no 2484 0.277208832447229 3585 2731747
SGTC_2704 st078022 71.1 µM -0.592257593543767 0.257005645587027 no 2485 0.276839054021779 3548 54697681
SGTC_1985 st071382 65.5 µM -0.592291299506996 0.25699405086333 no 2486 0.276827770518989 3533 6123237
SGTC_2607 solasodine 47.35 µM -0.592959679912877 0.256764186746285 no 2487 0.276604068151777 3463 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3098 9119039 49.47 µM -0.593221658635873 0.25667411829528 no 2488 0.276516409835754 3513 17161528
SGTC_463 ikarugamyin 104 µM -0.593742922677571 0.256494956330346 no 2489 0.276342034939772 3514 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1960 st011366 51.8 µM -0.59431711092812 0.256297679392122 no 2490 0.276150018127395 3520 3972846
SGTC_884 0851-0618 334 µM -0.595286029355338 0.255964962313326 no 2491 0.275826146439122 3517 9642473
SGTC_642 0335-0876 158 µM -0.596590237341455 0.255517466173468 no 2492 0.275390495414756 3526 6812350
SGTC_824 1304-0008 100 µM -0.596742399021253 0.255465283526905 no 2493 0.275339690161643 3499 768245
SGTC_1821 st053465 65.6 µM -0.601406266350333 0.253868551977485 no 2494 0.273784712996683 3477 675086
SGTC_2338 7999974 200 µM -0.601555823640703 0.253817436048675 no 2495 0.273734921148723 3566 315925
SGTC_545 4218-0007 221 µM -0.60157054666533 0.25381240428202 no 2496 0.273730019679981 3504 2840508
SGTC_1428 4049-0204 61.7 µM -0.60229256128309 0.253565711569585 no 2497 0.273489705766867 3548 X1428
SGTC_3340 9146634 11.102 µM -0.603321576670155 0.253214342870389 no 2498 0.273147390910346 3519 4907387
SGTC_684 1140-0066 328 µM -0.603475218727694 0.253161902065682 no 2499 0.273096298178747 3532 6813534
SGTC_718 1130-0073 349 µM -0.603839292648558 0.253037659879493 no 2500 0.272975246524582 3599 6740020
SGTC_1121 fusaric acid 630.51 nM -0.604180110084002 0.252921383171949 no 2501 0.272861951578782 3466 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3186 9110464 49.47 µM -0.604447083870806 0.252830319352633 no 2502 0.272773220121013 3547 17018021
SGTC_2892 9047358 58.44 µM -0.606149782761522 0.252249941076502 no 2503 0.272207647816112 3462 6466771
SGTC_1162 k048-0130 20.1 µM -0.606356106277256 0.252179661838211 no 2504 0.272139154542093 3495 6797406
SGTC_754 3474-0146 171 µM -0.608074379122471 0.251594774074431 no 2505 0.271569072023853 3428 24762078
SGTC_2818 7996756 12.99 µM -0.60839304454195 0.251486381478107 no 2506 0.271463411742914 3507 2241621
SGTC_1982 st072467 71.9 µM -0.608791888794624 0.251350751194317 no 2507 0.271331195331053 3452 3163533
SGTC_76 0433-0009 400.328 µM -0.608883358994682 0.251319651448773 no 2508 0.27130087758931 3520 2841569
SGTC_193 1273-0060 1.558 µM -0.60988626057409 0.250978799729263 no 2509 0.2709685772574 3462 2847393 YHR072W ERG7
SGTC_335 4077-0256 27.6 µM -0.610810444420802 0.250664918172687 no 2510 0.270662539064085 3544 3121989
SGTC_2983 9022671 12.99 µM -0.611190160980855 0.250536014915191 no 2511 0.270536848146551 3547 6405161
SGTC_3006 9075424 71.4286 µM -0.612198405736693 0.250193914252074 no 2512 0.270203248128488 3477 7465181
SGTC_988 1497-1057 103 µM -0.612824627733965 0.2499815599171 no 2513 0.269996152385264 3562 3533044
SGTC_27 0485-0001 32.618 µM -0.61302415282135 0.249913920274903 no 2514 0.269930184813037 3494 2054479
SGTC_2238 6671620 73.2395 µM -0.613489242023732 0.249756291268237 no 2515 0.26977644697629 3523 729941
SGTC_79 0052-0007 94.094 µM -0.613801739958635 0.249650408473727 no 2516 0.269673173670243 3591 2801472
SGTC_1154 4088-0362 150 µM -0.615148754446078 0.249194276371202 no 2517 0.269228243460993 3544 6618304
SGTC_2017 5132927 60.65 µM -0.615768826096207 0.248984453990437 no 2518 0.269023552418674 3488 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2217 6934799 96.0675 µM -0.616861742544113 0.248614857457057 no 2519 0.268662961468657 3508 675606
SGTC_1769 st044406 64.4 µM -0.617151428319775 0.248516942118653 no 2520 0.268567424841469 3497 670903
SGTC_1561 5-methoxyflavone 52.9 µM -0.619061729920581 0.247871764822123 no 2521 0.267937846739261 3524 94525
SGTC_755 1995-0008 37.3 µM -0.61916448216704 0.247837087062773 no 2522 0.267904003756836 3560 689533
SGTC_295 k015-0027 31 µM -0.620275933613127 0.247462149930668 no 2523 0.267538068319809 3523 3887424
SGTC_591 4299-0174 154 µM -0.620601673305571 0.247352322335529 no 2524 0.267430869216641 3475 5509088
SGTC_496 calpeptin 138 µM -0.622070514078815 0.246857406375011 no 2525 0.266947751221592 3513 73364 A calpain inhibitor.
SGTC_648 0375-0473 33.3 µM -0.625118868991529 0.245831977623573 no 2526 0.265946522334385 3551 1713139
SGTC_1465 k213-0056 144 µM -0.625231185860346 0.245794239345921 no 2527 0.265909668354262 3478 24048857 YMR208W ERG12
SGTC_35 0133-0054 64.071 µM -0.625336061296676 0.245759004184925 no 2528 0.265875258431099 3487 99677
SGTC_2105 5350118 200 µM -0.625858291541356 0.245583590069159 no 2529 0.265703946831406 3565 2133313
SGTC_550 4123-0385 25.7 µM -0.626424898564605 0.245393346143292 no 2530 0.265518141263546 3549 5731123
SGTC_1165 k072-0275 30.3 µM -0.629235292576488 0.244450900296412 no 2531 0.264597513376461 3603 6153523 YGL055W OLE1
SGTC_1709 st033179 39.1045 µM -0.63109442717646 0.243828525976436 no 2532 0.263989392364945 3553 573381
SGTC_887 0885-0007 9.62 µM -0.632264238453564 0.243437352183591 no 2533 0.263607113729094 3581 5719458
SGTC_774 k060-0086 136 µM -0.632801804483509 0.243257708970934 no 2534 0.263431539125056 3599 5911235
SGTC_2529 gangaleoidin 93.61 µM -0.633011920588636 0.243187512089633 no 2535 0.263362929270498 3600 4565183
SGTC_160 3453-0671 289.699 µM -0.634620051897368 0.242650620532192 no 2536 0.262838123540409 3524 5322268
SGTC_2903 5923464 63.88 µM -0.634837985300941 0.242577910582908 no 2537 0.262767043218649 3605 2876576
SGTC_2361 9034121 116 µM -0.636311539757328 0.24208659274614 no 2538 0.262286692485013 3544 6496917
SGTC_647 0140-0236 81 µM -0.636634233023726 0.241979071261649 no 2539 0.262181560682074 3586 990837
SGTC_1056 3448-1962 115 µM -0.637611379179044 0.241653643927224 no 2540 0.261863343234973 3558 715507
SGTC_2391 6285546 200 µM -0.637829460333537 0.241581046940618 no 2541 0.261792349966623 3518 846083
SGTC_2413 inermin 26.06 µM -0.638032893076287 0.241513336937633 no 2542 0.261726134185475 3646 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1218 1348-1416 30.7 µM -0.639841425076683 0.240911843378792 no 2543 0.26113784903202 3576 6787668
SGTC_188 3229-0966 278.469 µM -0.640445700320025 0.240711051282269 no 2544 0.260941440003993 3646 5722370
SGTC_447 ml7 120 µM -0.640579357292034 0.240666651269509 no 2545 0.260898007420811 3597 4216 Selective myosin light chain kinase inhibitor.
SGTC_1028 k015-0029 4.8 µM -0.640894888296585 0.240561851523176 no 2546 0.260795488601742 3580 4588309
SGTC_2068 5226020 147 µM -0.642095349868039 0.240163360151531 no 2547 0.260405637513085 3573 1810509
SGTC_3046 9092212 49.47 µM -0.642245321921918 0.240113602452565 no 2548 0.260356955040213 3584 25236637
SGTC_2911 7942208 15.64 µM -0.644687410579314 0.239304158065643 no 2549 0.259564888187538 3571 1243384
SGTC_1905 st060207 84.5 µM -0.644994356235352 0.239202524715824 no 2550 0.259465421548907 3523 1948547
SGTC_873 0591-4978 488 µM -0.645194542620282 0.239136253337479 no 2551 0.259400561172859 3659 3305145
SGTC_2741 miltefosine 3.04 µM -0.645579581999901 0.23900881489139 no 2552 0.25927583199037 3494 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1396 3511-0007 98.6 µM -0.645634570276623 0.238990618171528 no 2553 0.259258021685228 3538 X1396
SGTC_273 hydroxyurea 18.1 mM -0.64772987553734 0.238297804410419 no 2554 0.258579838834737 3637 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2183 6420625 130.508 µM -0.648816933617817 0.237938801977331 no 2555 0.258228355410716 3618 2897619
SGTC_2757 clomiphene 4.22 µM -0.651705544816194 0.236986276631781 no 2556 0.257295572459968 3651 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_677 0929-0063 136 µM -0.652570275800661 0.236701538008492 no 2557 0.257016676731242 3566 1539583
SGTC_2817 7995342 71.43 µM -0.652683881824468 0.236664143806545 no 2558 0.256980047853236 3539 18879975
SGTC_2798 7813637 45.45 µM -0.653567839016566 0.236373294279177 no 2559 0.256695134990257 3596 956368
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.653754966080579 0.236311748877213 no 2560 0.256634842188414 3606 16486 A toxic proline analog.
SGTC_2528 xanthyletin 44.79 µM -0.655550667777913 0.235721598022397 no 2561 0.25605663782452 3637 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2917 7979103 53.79 µM -0.655700419489988 0.235672419407107 no 2562 0.256008449454341 3615 2980565
SGTC_3155 9099265 49.47 µM -0.656067642753064 0.235551846868015 no 2563 0.255890301281143 3563 25236499
SGTC_1303 1160-0052 261 µM -0.656614835577391 0.235372247035982 no 2564 0.255714303603214 3617 3562476
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.65730607877571 0.235145475027871 no 2565 0.255492064321397 3617 442882
SGTC_2186 6124449 200 µM -0.659102139556718 0.234556816622439 no 2566 0.254915090926157 3576 3834182 YLR033W RSC58
SGTC_3298 9116858 71.43 µM -0.661569274930804 0.233749544255399 no 2567 0.254123652019438 3626 2506942
SGTC_913 3487-1245 167 µM -0.661911580198133 0.233637660196682 no 2568 0.254013944906973 3574 4016153
SGTC_1354 1498-1681 81 µM -0.663382096182871 0.233157353176026 no 2569 0.253542934764176 3650 5754243
SGTC_1281 0884-0031 11.8 µM -0.664078712434074 0.232930012498505 no 2570 0.25331996701964 3630 1548255
SGTC_1987 st072290 61.9 µM -0.665727494527682 0.232392423461736 no 2571 0.252792648111475 3615 54697379
SGTC_2975 9084847 53.72 µM -0.667935259601477 0.231673658789086 no 2572 0.25208745948995 3611 27211724
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.669051598435766 0.231310693252293 no 2573 0.251731281913205 3561 641818 YHR062C RPP1
SGTC_1738 st035555 74 µM -0.669101746040921 0.231294395746776 no 2574 0.25171528812468 3638 5331140
SGTC_2233 sulbentine 40.3845 µM -0.669436576716465 0.231185595306838 no 2575 0.251608512911107 3613 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1357 1503-1303 39.5 µM -0.669800636586314 0.231067329494408 no 2576 0.251492443863005 3638 292895
SGTC_2670 beta-carotene 100 µM -0.670028849877267 0.230993211023816 no 2577 0.251419699656857 3565 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3129 9127257 49.47 µM -0.671982327799896 0.230359309265568 no 2578 0.250797473425734 3541 837894
SGTC_2731 amoxapine 43.43 µM -0.672523879039705 0.230183748747853 no 2579 0.250625121747509 3665 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2072 5231554 129 µM -0.673941325180078 0.229724594415509 no 2580 0.250174308850272 3695 789545
SGTC_134 0269-0018 6.916 µM -0.674096134298751 0.229674478076327 no 2581 0.250125098513038 3559 4378915
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.674191962263177 0.229643458768635 no 2582 0.250094639531396 3594 6857784
SGTC_258 haloperidol 50.781 µM -0.674754972185436 0.229461261060735 no 2583 0.249915726204285 3613 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3081 9117243 49.47 µM -0.674823598678024 0.229439058129903 no 2584 0.249893922719134 3655 45595589
SGTC_3310 9130229 44.1445 µM -0.674894490378763 0.229416123593986 no 2585 0.249871400609604 3643 7761258
SGTC_1367 1812-0510 76.9 µM -0.677810461397728 0.228473877046822 no 2586 0.248945938590236 3635 1142582 YDR527W RBA50
SGTC_2154 5570129 200 µM -0.679237986685306 0.228013390381468 no 2587 0.248493540955651 3655 673366
SGTC_1017 4239-0030 168 µM -0.680444149755753 0.22762471727147 no 2588 0.248111637027771 3632 1149593
SGTC_2076 5212012 200 µM -0.680889681601159 0.22748124380917 no 2589 0.247970648790392 3546 604802
SGTC_1067 clotrimazole 1.36 µM -0.681454901815838 0.227299300729755 no 2590 0.247791846793698 3670 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2795 7780010 54.55 µM -0.681788680421489 0.227191896688702 no 2591 0.247686291466159 3628 953673
SGTC_784 4579-0127 173 µM -0.682233874635018 0.227048685610109 no 2592 0.247545539055672 3718 1948547
SGTC_2438 5259590 200 µM -0.682407382248219 0.226992885077005 no 2593 0.247490694538316 3657 1201127
SGTC_2508 celastrol 40.54 µM -0.682832788774356 0.226856105879323 no 2594 0.247356254052561 3608 122724 Celastrol is a natural product and antioxidant.
SGTC_3179 9107801 49.47 µM -0.683302338519851 0.226705187489894 no 2595 0.247207908397055 3654 4818259
SGTC_1070 indatraline 8.81 µM -0.683782888034479 0.226550792336336 no 2596 0.247056136839303 3635 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2214 7179297 48.276 µM -0.684053208872113 0.226463967386255 no 2597 0.246970783544003 3667 769744
SGTC_2084 5306078 60.6385 µM -0.684545834450133 0.226305788213838 no 2598 0.246815278533559 3602 679340
SGTC_656 4090-1979 187 µM -0.684821159699223 0.226217410092345 no 2599 0.246728390628326 3668 22330961
SGTC_1187 1391-0724 117 µM -0.686051259856006 0.225822791954969 no 2600 0.246340392347845 3697 6997986
SGTC_2654 protoveratrine a 100 µM -0.687050049493821 0.225502665206305 no 2601 0.246025594799725 3628 5702278 A heart drug and vasodilator.
SGTC_317 4495-0002 170 µM -0.689810314240734 0.22461929696278 no 2602 0.245156740784869 3639 15991618
SGTC_641 4092-0595 30 µM -0.690467033968986 0.224409416219833 no 2603 0.24495026707385 3674 786260
SGTC_2138 5575593 77.673 µM -0.691546041355908 0.22406481855587 no 2604 0.244611228721344 3656 762213
SGTC_303 1348-1668 34.2 µM -0.691796574812238 0.223984849849543 no 2605 0.244532543973452 3683 5380509
SGTC_2616 abietic acid 100 µM -0.69236798711338 0.223802519312632 no 2606 0.244353132206954 3657 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2683 piperine 63.03 µM -0.693893101179074 0.223316287746854 no 2607 0.243874625166562 3639 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_81 0411-0046 9.971 µM -0.694246077035753 0.223203838942698 no 2608 0.243763950515393 3562 12925265
SGTC_1257 0669-0121 16 µM -0.695365116461389 0.222847555631483 no 2609 0.243413257945022 3695 4307855
SGTC_572 0960-0087 17.7 µM -0.696717544881191 0.222417397951933 no 2610 0.242989788337946 3673 6796365
SGTC_395 anisomycin 6.25 µM -0.69686331491675 0.222371062161442 no 2611 0.242944168927402 3644 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2565 isoliquiritigenin 100 µM -0.697003953594127 0.22232636269064 no 2612 0.242900159791316 3644 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1628 st004252 77.7 µM -0.697433206548635 0.222189964072603 no 2613 0.242765863166524 3652 692968
SGTC_3255 9139072 49.47 µM -0.699582396934209 0.221507759891893 no 2614 0.242094069480159 3690 17646060
SGTC_2890 9046729 58.44 µM -0.700760726089064 0.221134238944336 no 2615 0.241726175767155 3619 903329
SGTC_624 k048-0052 28 µM -0.701860131801287 0.220786061307952 no 2616 0.241383197071478 3649 6835531
SGTC_345 1362-0200 395 µM -0.70201581874391 0.220736781229345 no 2617 0.241334649206471 3674 1419823
SGTC_2122 5258151 111.688 µM -0.703027220164123 0.220416792581727 no 2618 0.241019393084079 3679 2173356
SGTC_2921 7974240 10.71 µM -0.704259624703212 0.220027242248062 no 2619 0.240635552680036 3692 2979074 YDR527W RBA50
SGTC_1417 3966-0327 90.4 µM -0.704502236243941 0.219950601806057 no 2620 0.24056002895964 3731 651118
SGTC_82 0054-0107 293.755 µM -0.704571761891782 0.219928641633943 no 2621 0.24053838836368 3679 3104697
SGTC_1294 1000-1494 117 µM -0.706047754195798 0.219462735898827 no 2622 0.240079220304593 3677 712797 YDL207W GLE1
SGTC_2370 9071495 200 µM -0.706779150724944 0.219232076506688 no 2623 0.239851866541315 3639 21791103
SGTC_1524 corynanthine 62.1 µM -0.707901247058777 0.218878473754853 no 2624 0.239503292625924 3744 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_140 0062-0056 502.533 µM -0.708413957785424 0.218717014084168 no 2625 0.239344113576309 3674 3758964
SGTC_2680 butyl paraben 22.24 µM -0.708865052496662 0.218575014849303 no 2626 0.239204111982254 3728 7184 An antifungal and steroid mimetic.
SGTC_224 benfluorex 43.875 µM -0.711272918542043 0.217817945718083 no 2627 0.238457565008137 3676 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_269 exalamide 29 µM -0.711593808830987 0.217717167345317 no 2628 0.238358170979785 3666 3316 A derivative of salicylamide.
SGTC_31 0508-1974 57.237 µM -0.712610702410792 0.217397980869644 no 2629 0.238043343632846 3648 6810525
SGTC_2878 9043973 25.97 µM -0.713268463850541 0.217191664156142 no 2630 0.237839824026617 3750 6465167
SGTC_2623 humulene 100 µM -0.716155430198422 0.216287462700883 no 2631 0.2369476901239 3647 6187145 An anti-inflammatory.
SGTC_1814 st052110 31.539 µM -0.716294380522054 0.216243998324453 no 2632 0.236904797970954 3673 674163
SGTC_1632 st005650 90 µM -0.71719935730453 0.215961040680577 no 2633 0.236625547897274 3725 2759605
SGTC_2082 5219693 150 µM -0.718320906655655 0.215610665473883 no 2634 0.236279721123652 3703 2834649
SGTC_2754 granisetron 64.02 µM -0.718422290738393 0.21557900905132 no 2635 0.236248473332406 3688 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1373 2887-0003 58.5 µM -0.719191958802346 0.215338773862182 no 2636 0.236011326629394 3704 776948
SGTC_2359 9039622 200 µM -0.719708328901519 0.215177687240758 no 2637 0.235852298522179 3671 6463596
SGTC_2588 indole-3-carbinol 100 µM -0.721255627660913 0.214695411530523 no 2638 0.235376125999097 3712 3712 Induces cell cycle arrest.
SGTC_793 0488-0545 106 µM -0.72203745342407 0.214451964266666 no 2639 0.235135725447703 3713 292548
SGTC_2245 6637752 200 µM -0.722115210955005 0.214427760671189 no 2640 0.235111823504548 3720 681890
SGTC_294 k038-0071 157 µM -0.722249833508374 0.214385860449668 no 2641 0.235070444954558 3712 24152826
SGTC_1933 st074711 15.9 µM -0.722897251772586 0.21418442307778 no 2642 0.234871506053263 3697 17250958
SGTC_1031 k035-0009 16 µM -0.725899166087273 0.213251849310091 no 2643 0.23395029388699 3751 5180959
SGTC_1494 4358-1428 177 µM -0.725950859256821 0.213235811091382 no 2644 0.233934448101576 3733 1564571
SGTC_2236 dapsone 200 µM -0.726872158310418 0.212950088702946 no 2645 0.233652137101923 3735 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1184 1269-1718 139 µM -0.726941727648246 0.212928522246559 no 2646 0.233630826844272 3744 5403821
SGTC_1962 st076595 64.5 µM -0.727554131069578 0.2127387325242 no 2647 0.233443283885131 3740 279619
SGTC_1134 3477-0009 42.5 µM -0.729075001728548 0.21226782747323 no 2648 0.232977892556075 3745 3973534
SGTC_1423 4048-0112 5.59 µM -0.729132183473857 0.212250134261501 no 2649 0.232960404814538 3729 X1423
SGTC_2497 7-hydroxyflavone 100 µM -0.73057771474061 0.211803143475294 no 2650 0.232518564077205 3696 5281894
SGTC_1132 3456-3614 2.5 µM -0.730659340857273 0.211777919284052 no 2651 0.232493628165091 3797 3125502
SGTC_1021 4476-0760 85.3 µM -0.731178734001444 0.211617457033916 no 2652 0.232334993914523 3735 746768
SGTC_2567 aureobasidin a 60 nM -0.731473557590004 0.211526405379335 no 2653 0.232244975012394 3835 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_707 0865-0008 204 µM -0.732776964755344 0.211124143418353 no 2654 0.23184723651555 3717 723043
SGTC_888 0916-0002 6.97 µM -0.73367451456379 0.21084739938647 no 2655 0.231573567316486 3798 2802138 YIL048W NEO1
SGTC_374 0880-0231 82.3 µM -0.734237985404326 0.210673771604579 no 2656 0.231401853169638 3688 6833587
SGTC_1780 st038448 24.544 µM -0.734864682586824 0.210480759834825 no 2657 0.23121095462833 3782 728868 YDL195W SEC31
SGTC_639 0833-0042 114 µM -0.735557158205674 0.210267610206199 no 2658 0.231000121504364 3720 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.735771210840676 0.210201748719489 no 2659 0.230934972142253 3690 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1153 4055-0057 267 µM -0.735865824400311 0.210172641098035 no 2660 0.23090617869534 3751 882706
SGTC_3300 9124615 50.48 µM -0.73631878691182 0.210033321133594 no 2661 0.23076835781305 3743 24824903
SGTC_1913 st060213 96.1 µM -0.736532418058486 0.209967632359693 no 2662 0.230703373165783 3743 688959
SGTC_74 000s-0487 160.283 µM -0.737049054292891 0.20980882340895 no 2663 0.23054625939688 3673 677548
SGTC_1302 1159-0335 255 µM -0.740053718071436 0.208886619483674 no 2664 0.2296337000015 3757 649284
SGTC_1927 st060202 13.8 µM -0.741109575601138 0.208563119185716 no 2665 0.229313502051557 3688 688887
SGTC_144 4161-2749 112.381 µM -0.742464136073259 0.20814853323169 no 2666 0.228903086630618 3665 797501 YMR168C CEP3
SGTC_2730 imipramine 71.33 µM -0.747445550106322 0.206628076577946 no 2667 0.227397329361289 3756 3696 A tricyclic antidepressant.
SGTC_517 1365-0151 113 µM -0.747881348079603 0.206495373361233 no 2668 0.227265864458287 3814 768657
SGTC_2966 9084041 48.03 µM -0.748216652705972 0.206393305374894 no 2669 0.227164744020242 3706 17741380
SGTC_1706 st031321 9.9705 µM -0.749552067893187 0.205987096704996 no 2670 0.226762264157258 3769 6103185
SGTC_1919 st067113 52.3 µM -0.749981762385701 0.205856492466082 no 2671 0.226632844442767 3789 1268243
SGTC_466 geldanamycin 89.2 µM -0.751154058111462 0.205500426947616 no 2672 0.226279972715557 3649 5288382 HSP90 inhibitor.
SGTC_206 4546-0025 72.014 µM -0.75190779452484 0.205271685198673 no 2673 0.226053255201198 3768 6620745 YIL048W NEO1
SGTC_1775 st081588 35.1725 µM -0.75227434119644 0.205160501360704 no 2674 0.225943047493789 3791 1426443 YGL099W LSG1
SGTC_365 0121-0052 13.6 µM -0.752744566126145 0.205017921425265 no 2675 0.225801711869229 3786 3101739
SGTC_1637 st007924 17.4 µM -0.757190300836709 0.203672814850059 no 2676 0.224467930097938 3742 683336
SGTC_3278 9139605 49.47 µM -0.757309623841386 0.203636785007516 no 2677 0.224432193266324 3774 7958859
SGTC_2809 7964133 12.99 µM -0.758922129209975 0.203150258306613 no 2678 0.223949570195353 3804 1253665
SGTC_1013 4112-3890 241 µM -0.760314776001209 0.202730626521478 no 2679 0.223533225830606 3731 705171
SGTC_190 3970-0790 3.722 µM -0.761232962600692 0.20245424243018 no 2680 0.223258966629333 3714 2832352
SGTC_3045 9092950 49.47 µM -0.761296008973104 0.202435273060017 no 2681 0.223240141922811 3743 44120432
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.7614931499243 0.202375964218173 no 2682 0.223181284404785 3804 1377
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.761891625582768 0.202256116597838 no 2683 0.223062344277944 3809 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_835 0312-0010 67.2 µM -0.762078734012634 0.202199855540397 no 2684 0.2230065071487 3738 1626196
SGTC_2835 9006588 71.43 µM -0.762896089239552 0.201954197318163 no 2685 0.222762684350802 3826 2345538
SGTC_520 3584-0023 682 µM -0.762999514777266 0.20192312524442 no 2686 0.222731842618932 3802 1340790
SGTC_1279 0874-0590 65.2 µM -0.763919241526906 0.201646938178205 no 2687 0.222457685064936 3818 3523074
SGTC_749 1000-0129 128 µM -0.766205549286766 0.200961358174797 no 2688 0.221777003494643 3816 708470
SGTC_1262 0737-0114 49.6 µM -0.766354525605699 0.200916734211968 no 2689 0.221732691461065 3807 765919
SGTC_2669 eugenol 100 µM -0.767512965604884 0.200569941138158 no 2690 0.221388293686963 3745 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3178 9107506 49.47 µM -0.768016905554819 0.200419192854166 no 2691 0.221238570663295 3799 8897194
SGTC_3012 9080433 71.4286 µM -0.769577163972461 0.199952889861125 no 2692 0.220775377705001 3778 17688859
SGTC_2134 5324836 1.464 µM -0.771065040087324 0.199508827466384 no 2693 0.22033419058892 3771 699272
SGTC_2753 fluvastatin 17.09 µM -0.771299315976907 0.19943896104927 no 2694 0.220264768859247 3825 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_3333 9141820 12.094 µM -0.771819529574847 0.199283874155528 no 2695 0.220110661579241 3797 1939433
SGTC_2689 tacrolimus 100 µM -0.772367612178202 0.199120557500123 no 2696 0.219948365351412 3805 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1231 0242-0792 125 µM -0.774819591235547 0.198390909028757 no 2697 0.219223135535658 3801 3707635
SGTC_1989 st071868 50.2 µM -0.776636567884976 0.197851263765013 no 2698 0.218686610297901 3791 16414057
SGTC_488 nitrendipine 139 µM -0.776785174442991 0.197807166621813 no 2699 0.218642762528835 3836 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_703 3875-0075 71.8 µM -0.777437826230934 0.197613570660823 no 2700 0.218450251382492 3826 2850814
SGTC_1089 terbinafine 2.25 µM -0.778178786228755 0.19739391873322 no 2701 0.218231810543758 3801 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1604 st002052 72.4 µM -0.778190438376869 0.197390465722613 no 2702 0.218228376404302 3820 6254834 YHR062C RPP1
SGTC_543 3844-1095 191 µM -0.78011893975123 0.196819474922572 no 2703 0.217660434642476 3816 4230703
SGTC_1251 0490-5699 265 µM -0.782082050864822 0.196239265292246 no 2704 0.217083177276307 3799 3883818
SGTC_1344 1488-0097 29.1 µM -0.78254942374592 0.196101283338413 no 2705 0.216945875684478 3838 747966
SGTC_1554 st069299 38.7 µM -0.782932695576928 0.195988174364227 no 2706 0.216833318189208 3755 24207999
SGTC_2145 5634607 200 µM -0.784785973055206 0.195441804389444 no 2707 0.216289532810747 3798 308662
SGTC_3174 9107204 49.47 µM -0.785768661858358 0.195152470831085 no 2708 0.216001514599955 3828 3938802
SGTC_1673 st016611 27.3 µM -0.786091837674821 0.195057374926957 no 2709 0.215906842931402 3858 5226799
SGTC_1182 1222-0449 220 µM -0.786694425683644 0.194880136004985 no 2710 0.215730384009942 3808 658318
SGTC_1693 xanthone 101.9 µM -0.787274212220725 0.194709696152741 no 2711 0.215560681103573 3857 7020 An insecticide.
SGTC_1358 1509-0022 2.48 µM -0.790914492616374 0.193641636476618 no 2712 0.214496945336995 3855 3258434
SGTC_194 1486-1323 56.904 µM -0.792803037955936 0.193088946823479 no 2713 0.213946293128452 3852 5178754
SGTC_3132 9126706 49.47 µM -0.796899122978086 0.191893526886482 no 2714 0.21275481014694 3874 850858
SGTC_1782 st039423 80.636 µM -0.797986757304488 0.191576869573019 no 2715 0.212439087508619 3859 2068169
SGTC_3167 9103034 49.47 µM -0.79920193772331 0.191223456927262 no 2716 0.212086664276901 3852 5127859
SGTC_1867 st057372 64 µM -0.800838117102611 0.190748236396997 no 2717 0.211612684545173 3816 688837
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.800888968836043 0.190733478374357 no 2718 0.21159796340643 3791 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.801066990610361 0.190681819001844 no 2719 0.21154643235972 3918 4213774
SGTC_1666 st014829 29 µM -0.801425244771436 0.190577884801864 no 2720 0.211442752645528 3848 3858230
SGTC_2296 7971656 126.45 µM -0.801534787848677 0.190546111871979 no 2721 0.211411056526993 3898 666570
SGTC_2760 etidronate 98.04 µM -0.801690814212797 0.190500862096902 no 2722 0.211365915346684 3832 3305 A chelator and antioxidant.
SGTC_950 1165-0508 94.1 µM -0.801742231800008 0.190485951740375 no 2723 0.211351040568301 3858 6148369
SGTC_451 chloral hydrate 100 µM -0.801972981539555 0.190419046478004 no 2724 0.211284293698623 3905 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2120 5538279 151.968 µM -0.802990257800087 0.190124262066112 no 2725 0.210990182748282 3819 2058197
SGTC_3093 9117344 49.47 µM -0.804948892525923 0.189557482849781 no 2726 0.210424586312767 3890 24824913
SGTC_200 k038-0079 37.545 µM -0.806522011958776 0.189103015594461 no 2727 0.209970960594875 3801 3436683
SGTC_1122 capsaicin 818.572 nM -0.807164545582886 0.188917583647144 no 2728 0.209785844610503 3945 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_260 nsc-65238 3.989 µM -0.808791760665495 0.188448478963395 no 2729 0.209317468150236 3791 3246252
SGTC_886 0866-0150 153 µM -0.80907520938943 0.18836683795897 no 2730 0.209235943452594 3884 271463
SGTC_416 estradiol valerate 100 µM -0.812979090416388 0.187244633753743 no 2731 0.20811502328751 3891 13791 A steroid.
SGTC_1633 st005664 67.9 µM -0.813003193413353 0.187237718005382 no 2732 0.208108113628035 3860 2063822
SGTC_1736 st036774 51 µM -0.813475396954551 0.187102262942474 no 2733 0.207972773305761 3947 1272247
SGTC_127 0180-0333 59.125 µM -0.815224236694591 0.186601123515529 no 2734 0.207471983505278 3767 771601
SGTC_876 0720-0963 56.8 µM -0.817249050110164 0.186021941632538 no 2735 0.206893058401015 3870 765861
SGTC_2511 berberine 10.47 µM -0.817262836712132 0.186018001907894 no 2736 0.206889119880784 3840 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1033 k072-0102 21.3 µM -0.818098720776483 0.185779232374752 no 2737 0.206650409635488 3803 5965931
SGTC_1978 st071761 42 µM -0.818566715023062 0.18564563328952 no 2738 0.206516831946656 3896 5147680
SGTC_2284 7945075 39.21 µM -0.818755836080685 0.185591661507198 no 2739 0.206462866409026 3920 1245402
SGTC_2174 5790901 200 µM -0.819139551408487 0.185482185907629 no 2740 0.206353399232557 3904 786020
SGTC_2778 tioconazole 65.09 nM -0.820323998804933 0.185144510961759 no 2741 0.206015714414749 3791 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1000 4048-0884 8.67 µM -0.822564110103971 0.184506920821177 no 2742 0.205377957587498 3884 13040088
SGTC_364 0083-0097 67.7 µM -0.822918386515791 0.184406210354557 no 2743 0.205277203041934 3962 5207356
SGTC_2029 5175081 200 µM -0.823745740231421 0.184171151005133 no 2744 0.205042021925097 3853 1380876
SGTC_2792 7535235 81.82 µM -0.824875499353164 0.1838504766446 no 2745 0.204721138731772 3873 1281891
SGTC_1590 st077108 57.8 µM -0.825958919646489 0.183543282113771 no 2746 0.204413697817359 3848 5489485
SGTC_2114 5491910 81.25 µM -0.827469078124959 0.183115623709831 no 2747 0.203985620727579 3946 2849228
SGTC_2263 7948595 193.29 µM -0.827690313571707 0.183053024780607 no 2748 0.20392295310713 3856 2971371
SGTC_1216 1165-0504 9.65 µM -0.829302983778042 0.182597120584304 no 2749 0.203466491459845 3858 6304004
SGTC_2512 diallyl trisulfide 49.23 µM -0.830306480878948 0.182313788722247 no 2750 0.203182762394918 3897 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2046 4110841 106 µM -0.830987916077777 0.18212154596036 no 2751 0.202990227918272 3900 44119630 YMR134W ERG29
SGTC_1770 st043884 66.3 µM -0.831028717599598 0.182110039281044 no 2752 0.202978703208159 3865 670149
SGTC_1380 2291-0730 164 µM -0.832112439311847 0.181804578853217 no 2753 0.202672740549418 3922 2999191
SGTC_2259 7964009 200 µM -0.832624635625029 0.181660321560405 no 2754 0.202528230254794 3924 313134
SGTC_1454 4239-0054 42.6 µM -0.833769951299933 0.181338008888537 no 2755 0.202205315567677 4014 1340767
SGTC_1525 8-methoxypsoralen 92.5 µM -0.833837247200879 0.181319081742027 no 2756 0.202186351489389 3885 4114 Related to psoralen; DNA damaging agent.
SGTC_2480 5767542 37.17 µM -0.834100323478197 0.18124510272822 no 2757 0.202112226440534 3863 2867358
SGTC_965 1291-5240 308 µM -0.834492095272465 0.181134968616132 no 2758 0.202001869955907 3873 2834598
SGTC_174 3553-0389 74.3 µM -0.834724717475371 0.181069594162963 no 2759 0.201936360692352 3901 738071
SGTC_583 1488-1091 88.9 µM -0.834822626939253 0.181042082819661 no 2760 0.201908791990497 3986 4303273
SGTC_1688 st021091 57.6 µM -0.835293108383984 0.180909919909376 no 2761 0.201776348354829 3893 3656366
SGTC_928 2764-0428 58.7 µM -0.835638427286285 0.180812954887544 no 2762 0.201679171915801 3939 662578
SGTC_3182 9108849 49.47 µM -0.836285499299863 0.180631345790072 no 2763 0.201497154413008 3920 17133045
SGTC_1437 4092-1038 11.6 µM -0.836994027451278 0.18043261948327 no 2764 0.201297962607787 3894 3977136
SGTC_3001 9076041 71.4286 µM -0.838037949436592 0.180140072729016 no 2765 0.201004695162062 3869 16004211
SGTC_1333 1482-0047 286 µM -0.838694412709514 0.179956259262016 no 2766 0.200820407248351 3863 3811116
SGTC_2367 9070478 135.38 µM -0.83887018517413 0.17990706196562 no 2767 0.200771080132956 3841 572802
SGTC_2449 5812982 45.77 µM -0.840173871027503 0.179542434508046 no 2768 0.200405453153624 3863 776185
SGTC_2001 4023502 57.655 µM -0.840932748845244 0.17933039826205 no 2769 0.200192805345795 3914 108941 YCR052W RSC6
SGTC_666 0272-0154 136 µM -0.841978963538332 0.179038336194369 no 2770 0.19989986430887 3911 6870312
SGTC_644 1498-1197 63.3 µM -0.842269685754241 0.17895723113147 no 2771 0.199818507624083 3950 6741615
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.84459395371171 0.178309643384824 no 2772 0.199168793019888 3935 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2144 5628481 200 µM -0.844671352028128 0.17828810409519 no 2773 0.199147179385522 3886 2818399
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.846598230068516 0.177752399015774 no 2774 0.19860955040266 3886 66535 A nucleotide analog.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.8467386210766 0.177713407641263 no 2775 0.198570413367883 3930 688664
SGTC_497 capsazepine 133 µM -0.847712372495278 0.177443112174814 no 2776 0.198299087113214 3885 2733484 A calcium channel blocker.
SGTC_504 lovastatin 124 µM -0.8477618931455 0.177429373092284 no 2777 0.198285294652713 3924 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2308 7584454 197.62 µM -0.847958952350418 0.177374707348266 no 2778 0.198230415582874 3913 893577
SGTC_1225 1216-0074 20.6 µM -0.848106541956649 0.177333771818029 no 2779 0.198189319320087 3901 4241466
SGTC_2224 6650123 117.647 µM -0.852470845082147 0.176125983524377 no 2780 0.196976407002435 3865 2908370
SGTC_3022 9087993 49.47 µM -0.852652732864536 0.176075760726886 no 2781 0.196925955093662 3952 17173644
SGTC_2222 6885208 172.143 µM -0.853580286177592 0.175819786022591 no 2782 0.196668792681086 3847 609514
SGTC_3073 9114972 49.47 µM -0.854109603137105 0.175673817356051 no 2783 0.196522131756251 3868 41905075
SGTC_1906 st060206 94.7 µM -0.855941617845492 0.175169199361185 no 2784 0.196015036633067 3935 5133468
SGTC_762 1165-0429 115 µM -0.85623584356698 0.175088242331267 no 2785 0.195933670043486 3872 5967793
SGTC_986 1493-0483 84 µM -0.858209976745121 0.174545668105754 no 2786 0.195388264001335 3834 40079
SGTC_3350 9150499 3.57 µM -0.859461069973424 0.174202368835984 no 2787 0.1950430946216 3886 4910996 YPR165W RHO1
SGTC_2228 7354201 200 µM -0.859501233806482 0.174191355016722 no 2788 0.195032019797236 3927 753451
SGTC_2148 5546263 113.568 µM -0.859934463684938 0.174072581850047 no 2789 0.194912584765114 3898 792097
SGTC_1824 st053723 68.6 µM -0.860077745352351 0.174033311455677 no 2790 0.194873093930425 3946 675225
SGTC_625 k213-0058 121 µM -0.860312842663198 0.173968888590237 no 2791 0.194808307704918 3987 3655420
SGTC_2825 7998094 58.44 µM -0.861623084018696 0.173610125682268 no 2792 0.194447481948935 3924 2987815
SGTC_1820 st053765 18.6 µM -0.861672985167468 0.173596471343302 no 2793 0.194433747779831 3971 3690829
SGTC_911 3456-4043 236 µM -0.863777225222975 0.173021314900306 no 2794 0.19385514061343 3979 914281
SGTC_966 1300-0360 30.2 µM -0.864835765807953 0.172732441222794 no 2795 0.193564468745975 3908 70588
SGTC_1744 st037937 38.9 µM -0.867071785437214 0.172123247067627 no 2796 0.192951339315158 4004 1016152
SGTC_1297 1068-0111 14.1 µM -0.872038927374679 0.170774883360691 no 2797 0.191593570780332 3882 767057
SGTC_521 r062-0005 13.8 µM -0.87302904440819 0.170506919735714 no 2798 0.191323623459863 3837 2832033
SGTC_2945 9067681 61.76 µM -0.873206653929052 0.170458880286385 no 2799 0.191275224345523 4021 16456930
SGTC_3247 9135149 49.47 µM -0.873583599833722 0.170356953473782 no 2800 0.191172530351979 3908 8934436 YOR116C RPO31
SGTC_1453 4237-0541 195 µM -0.874191357700275 0.170192696948063 no 2801 0.191007025856538 3879 739892
SGTC_1605 st000082 49.1 µM -0.875453593434259 0.16985188140889 no 2802 0.190663574981324 3938 1114022
SGTC_3356 9151811 4.48 µM -0.875946150780427 0.169719005070225 no 2803 0.190529654362954 3924 1859254 YPR165W RHO1
SGTC_2358 9037157 4 µM -0.877959695020248 0.169176508315155 no 2804 0.189982795928734 3943 2388925
SGTC_2299 7976368 114.88 µM -0.87905523610372 0.168881811677946 no 2805 0.18968566364714 3992 2979718
SGTC_2455 5377712 9.75 µM -0.879177987556186 0.168848812534869 no 2806 0.189652388857001 3950 2243908
SGTC_290 2043-6722 48.1 µM -0.879440509813188 0.168778252859593 no 2807 0.189581237815983 3958 773758 YLR208W SEC13
SGTC_1267 0828-0272 9.49 µM -0.880532076668451 0.168485069132562 no 2808 0.189285568119092 4030 745334
SGTC_424 splitomicin 100 mM -0.885446488862091 0.167169166914919 no 2809 0.187957934185809 4052 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2303 7774051 200 µM -0.88654461972943 0.166876035207413 no 2810 0.187662060627007 3941 2953184
SGTC_1447 4239-0816 81.9 µM -0.889795338493412 0.166010243060856 no 2811 0.186787895030892 3965 1341554
SGTC_2280 7785178 200 µM -0.891034707049799 0.165680916933489 no 2812 0.186455275496532 3944 2954328
SGTC_2244 6635614 200 µM -0.892153077528822 0.16538410536301 no 2813 0.186155444312273 3883 836499
SGTC_2195 6536160 144.242 µM -0.892399875859021 0.165318652323222 no 2814 0.186089318819847 3888 3834386
SGTC_275 trichlorophene 5.69 µM -0.89306403809145 0.165142594048961 no 2815 0.185911439963701 3994 62616
SGTC_1777 st045864 34.765 µM -0.895211974597343 0.164574043373272 no 2816 0.185336892370542 3926 4691462
SGTC_3054 9094397 49.47 µM -0.89812259887164 0.16380563866943 no 2817 0.184560096073154 3987 2598354
SGTC_19 0279-0214 38.434 µM -0.901050059750016 0.163035141766625 no 2818 0.183780851972066 4015 3566274 YBR002C RER2
SGTC_2112 5488546 200 µM -0.90292167395382 0.162543776386377 no 2819 0.183283733319246 3941 600757
SGTC_1697 st025554 27.742 µM -0.902995972974476 0.162524290153313 no 2820 0.183264016108051 3948 1269519
SGTC_1947 st076332 61.6 µM -0.903737496961933 0.162329895657409 no 2821 0.183067305580538 3889 24208416
SGTC_2459 5811157 9.22 µM -0.905468775902698 0.161876621045413 no 2822 0.182608547178915 3949 2870684 YBR192W RIM2
SGTC_338 4055-0136 114 µM -0.906948986099993 0.16148973452358 no 2823 0.182216887395168 3923 2900563
SGTC_2216 7189485 200 µM -0.909206493384705 0.160900845679364 no 2824 0.18162056863832 3982 731273
SGTC_1156 4092-0367 4.88 µM -0.909538562547368 0.160814341195558 no 2825 0.181532955975768 3986 1357585
SGTC_2321 7390090 138.78 µM -0.909551646574138 0.160810933410073 no 2826 0.181529504446241 4008 649046
SGTC_799 1310-0557 151 µM -0.909917148887558 0.160715755971137 no 2827 0.181433102562986 4056 5354492
SGTC_3153 9100258 49.47 µM -0.91164787923316 0.160265570388378 no 2828 0.180977054677946 3913 25236848
SGTC_1745 st081495 74 µM -0.913995474283569 0.159656248732845 no 2829 0.180359611884485 3900 13842402 YBL026W LSM2
SGTC_1177 0983-0204 23.6 µM -0.914935863007443 0.159412595308151 no 2830 0.180112650729495 4033 766818
SGTC_811 0416-0114 265 µM -0.91538986957533 0.159295050014874 no 2831 0.179993497346709 4060 6612453
SGTC_2661 dactinomycin 12.96 µM -0.915768146093785 0.159197155088727 no 2832 0.179894257018651 3968 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2598 perillyl alcohol 100 µM -0.918398880624397 0.158517432278128 no 2833 0.179205038267711 4024 10819 An apoptosis inducer.
SGTC_2991 9074669 71.4286 µM -0.918747271362338 0.158427558861974 no 2834 0.179113889053696 3988 17333109
SGTC_2400 5203494 178.7 µM -0.919594490656042 0.158209143493953 no 2835 0.178892353414592 3914 6777674
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.921038449910761 0.157837342612668 no 2836 0.178515176497731 4032 6708561
SGTC_473 2-arachidonoylglycerol 10 µM -0.921591847132368 0.157695002190221 no 2837 0.178370756354878 3846 5282280 An endocannabinoid.
SGTC_2893 9048488 25.97 µM -0.921655863518179 0.157678541848908 no 2838 0.178354054742234 4033 6467338
SGTC_1032 k061-1018 98.7 µM -0.921670257893984 0.15767484082166 no 2839 0.178350299444285 4113 4005393
SGTC_1613 st002381 52.1 µM -0.922281575006257 0.157517713964637 no 2840 0.178190861066867 3990 551167
SGTC_982 1491-0518 27.5 µM -0.922587122745156 0.157439217600016 no 2841 0.178111204463841 3928 3091256
SGTC_2256 7954252 200 µM -0.924151164636459 0.15703781204241 no 2842 0.177703808796238 4028 2972920
SGTC_2041 5107442 45.335 µM -0.928258597478107 0.155986862614203 no 2843 0.176636722499843 4049 793005
SGTC_1342 1486-1464 234 µM -0.928516180180457 0.155921110975216 no 2844 0.176569939354248 4034 3253938
SGTC_996 3970-0799 1.8 µM -0.928667813204288 0.155882413039172 no 2845 0.176530633117455 4023 6615648 YGL040C HEM2
SGTC_961 1252-1571 372 µM -0.928794778082235 0.155850015478049 no 2846 0.176497725602376 4015 6813498
SGTC_1037 k284-1091 78.7 µM -0.930127113432598 0.155510311891888 no 2847 0.176152636995412 3974 3334711
SGTC_3237 9133362 49.47 µM -0.933206217451962 0.154727107586162 no 2848 0.175356752588584 3960 43845137
SGTC_208 k072-0098 12.366 µM -0.935439491250742 0.154160683063947 no 2849 0.174780926490878 3998 5948901
SGTC_2240 6690706 185.951 µM -0.93622147307169 0.153962673879908 no 2850 0.174579584761347 3869 805876
SGTC_2343 7990716 14.84 µM -0.939074591923387 0.153241650386216 no 2851 0.173846224171297 4023 6456862
SGTC_421 streptovitacin 30 mM -0.939925083563504 0.153027152709514 no 2852 0.1736279949306 4100 91467 include heat shock
SGTC_349 k015-0014 24 µM -0.940345606434007 0.152921168588949 no 2853 0.173520156607275 3998 2196908
SGTC_2194 5927483 104.545 µM -0.941225630734444 0.152699534135168 no 2854 0.173294622320708 4027 760979
SGTC_1238 0333-0287 48.8 µM -0.944145636026047 0.151965656839219 no 2855 0.172547615711321 3994 7226
SGTC_2254 7938975 95.19 µM -0.944423292311085 0.151895996395653 no 2856 0.172476691713123 4110 2969277
SGTC_2170 morpholine 200 µM -0.944660047968195 0.151836614160789 no 2857 0.172416229982701 4054 121171 Reacts with secondary amines.
SGTC_2109 5483026 200 µM -0.945089352045067 0.151728976944968 no 2858 0.172306630479863 4038 759335
SGTC_448 monastrol 171 µM -0.945359163761917 0.151661354389182 no 2859 0.172237771448686 3936 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2571 chrysanthemic acid 100 µM -0.946733700771762 0.151317166988009 no 2860 0.171887246541503 4062 2743 An insecticide.
SGTC_815 1582-0027 36.9 µM -0.948068220024272 0.150983497556072 no 2861 0.171547362819567 4082 3128206
SGTC_3224 9130643 49.47 µM -0.948244068692 0.150939566709548 no 2862 0.171502608623269 4078 17644395
SGTC_3078 9116413 49.47 µM -0.948329642555013 0.150918191563059 no 2863 0.171480832428624 3936 17177322
SGTC_327 1273-0057 3.96 µM -0.948680109716697 0.150830670822852 no 2864 0.171391666613428 3902 3108138
SGTC_1483 3453-0561 55.9 µM -0.948768623806036 0.150808571904503 no 2865 0.171369151557323 4040 4546991
SGTC_615 k087-0205 167 µM -0.948883446511483 0.150779907843132 no 2866 0.171339947276817 4024 9642773
SGTC_893 0958-0369 48.9 µM -0.949019077093413 0.150746054027119 no 2867 0.17130545477028 3985 6819948
SGTC_483 fpl-64176 144 µM -0.951490033962184 0.150130181486744 no 2868 0.170677837629052 4083 3423
SGTC_146 3448-8650 53.125 µM -0.952868545173019 0.149787324975745 no 2869 0.170328339529959 4019 2891488 YIL048W NEO1
SGTC_1440 4100-1550 40 µM -0.953175661497787 0.149711011716375 no 2870 0.170250537891911 4035 742806
SGTC_929 2805-0021 398 µM -0.953491647047073 0.149632521680974 no 2871 0.170170513185217 4104 3098024
SGTC_2291 7917025 104.35 µM -0.955115673709025 0.149229550708546 no 2872 0.169759601769833 3963 2964612
SGTC_2433 5607874 27.82 µM -0.955807428578946 0.149058125326709 no 2873 0.169584767283176 4020 2252428
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.957478568822987 0.148644539099349 no 2874 0.169162879232229 4044 616764
SGTC_2334 9017922 200 µM -0.961204465429655 0.147725190783143 no 2875 0.168224685796598 4125 3163164
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.962008426382379 0.147527317554117 no 2876 0.168022685596477 3956 5355888
SGTC_136 0097-0015 404.482 µM -0.962543378742071 0.147395751936771 no 2877 0.1678883620111 4038 4861337
SGTC_2581 avocatin a 64 µM -0.96327570038567 0.14721577305025 no 2878 0.167704592209563 4026 6710728 A skin care supplement.
SGTC_195 4234-0266 16.654 µM -0.964200531617171 0.146988692659597 no 2879 0.167472698955363 4044 2303354
SGTC_3118 9124250 49.47 µM -0.965296171388777 0.146719976568039 no 2880 0.167198244450117 3987 1504786
SGTC_949 1165-0505 146 µM -0.966232693232738 0.146490547107311 no 2881 0.166963878486278 4073 6244267
SGTC_3144 9087057 49.47 µM -0.966774700319335 0.146357876091798 no 2882 0.166828337260367 3881 17249618
SGTC_1648 st011736 69.8 µM -0.968975077065054 0.145820102637514 no 2883 0.16627881217355 4061 2855514
SGTC_1771 st048882 4.1505 µM -0.969265923749709 0.145749119027728 no 2884 0.16620626329904 4079 4580403
SGTC_482 fipronil 114 µM -0.969823356063815 0.14561313785388 no 2885 0.166067274388742 4128 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2868 9035608 32.47 µM -0.97072781668372 0.145392683432259 no 2886 0.165841918050724 4039 6462614
SGTC_2360 9040895 200 µM -0.974429369820783 0.144492802439258 no 2887 0.164921696319488 4087 4914414
SGTC_2933 9026794 32.47 µM -0.975650706866919 0.144196709540908 no 2888 0.164618793688914 4027 17586027
SGTC_1883 5-benzylidenerhodanine 20 µM -0.976947678602348 0.143882728406231 no 2889 0.164297527895154 4054 1273210
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.977051916555057 0.143857513699453 no 2890 0.164271725341729 4084 551469
SGTC_3041 9091929 49.47 µM -0.977483380378921 0.143753176186749 no 2891 0.164164950844609 4070 25236887
SGTC_2326 6164455 177.58 µM -0.977636907161898 0.143716062328853 no 2892 0.164126968380472 4044 2888790
SGTC_2834 9001755 58.44 µM -0.978948057248215 0.143399365812919 no 2893 0.163802822606953 3993 2989575
SGTC_1902 st060212 70.5 µM -0.979226357033304 0.143332205670729 no 2894 0.163734074136842 4056 688944
SGTC_539 4859-0462 2.54 µM -0.979572815550602 0.143248626942708 no 2895 0.163648514573211 4119 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1830 st055982 50.3 µM -0.980584776573344 0.143004692676523 no 2896 0.16339877227579 3984 455313 An antimicrobial agent.
SGTC_1082 camptothecin 424.86 nM -0.9814071468731 0.142806666294931 no 2897 0.163196001591352 3969 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_764 1951-2361 146 µM -0.985134036568856 0.141911557175711 no 2898 0.162279118272069 4066 5438930
SGTC_261 5-fluorouridine 15.376 µM -0.986038349072539 0.141694937054484 no 2899 0.162057147351548 4079 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_180 1486-1293 102.781 µM -0.986400176150381 0.141608327323122 no 2900 0.161968389342963 3956 4140536
SGTC_801 0866-0028 10.1 µM -0.987595730162296 0.141322405332897 no 2901 0.161675339135544 4067 6849771
SGTC_41 0478-0632 82.643 µM -0.987836938112787 0.1412647668653 no 2902 0.161616256969793 3991 3750424
SGTC_1900 st060200 72.8 µM -0.988452749443894 0.141117686368124 no 2903 0.161465482222056 4064 688945
SGTC_2703 st077852 53.4 µM -0.989246970467196 0.140928147840692 no 2904 0.161271161260531 4123 6281836
SGTC_2663 amphotericin b 100 µM -0.989282059836394 0.14091977785037 no 2905 0.161262579513245 4063 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2157 5649910 96.377 µM -0.990728298092107 0.14057509491938 no 2906 0.160909134651232 4082 2858091
SGTC_1916 st067606 49.2 µM -0.990871341814772 0.140541034339921 no 2907 0.160874203826777 4034 19590279
SGTC_2686 alizarin 95.37 µM -0.99428462622241 0.139729948299093 no 2908 0.160042159090816 4088 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1327 1436-0082 2.18 µM -0.994609315994172 0.139652959575742 no 2909 0.15996315739995 4068 15992205
SGTC_3058 9093861 49.47 µM -0.995418079976884 0.139461315153789 no 2910 0.159766484395862 4092 17217477
SGTC_2952 9073731 13.78 µM -0.996476382605248 0.139210810453206 no 2911 0.159509368321967 4157 16457353
SGTC_25 0118-0223 35.662 µM -0.999136373834285 0.138582531999589 no 2912 0.158864316417429 4071 5333628
SGTC_2695 st077686 51.995 µM -1.00317772356582 0.137631684896319 no 2913 0.157887559557223 4125 2876092
SGTC_2425 5628681 7.85 µM -1.00446880837444 0.137328859692168 no 2914 0.157576349231045 4160 5714958
SGTC_1179 1021-1431 9.29 µM -1.00447143971565 0.137328242973504 no 2915 0.157575715369649 4126 2840958
SGTC_1455 4262-0120 131 µM -1.00449636507374 0.137322401204819 no 2916 0.157569711205856 4178 1529587
SGTC_1842 st055362 61.2 µM -1.0055562090708 0.137074162050108 no 2917 0.157314548972499 4065 676032
SGTC_1363 1636-0063 10.4 µM -1.0068421476115 0.136773378410906 no 2918 0.157005318400293 4102 6072185
SGTC_1093 fluphenazine 7.97 µM -1.00748164860478 0.136623965934665 no 2919 0.156851686098496 4093 6602611 An atypical antipsychotic.
SGTC_285 1486-1325 46 µM -1.0075345922746 0.13661160122446 no 2920 0.156838971463711 4144 22310230
SGTC_1849 st056239 19.2 µM -1.00899951016232 0.136269780994764 no 2921 0.156487434552769 4106 5393181
SGTC_1080 nisoldipine 24.4 µM -1.01139075670663 0.135713071824398 no 2922 0.155914721710351 4095 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2824 7998404 51.95 µM -1.01328263495245 0.135273726503573 no 2923 0.155462589755349 4066 837851
SGTC_1614 st002383 48.6 µM -1.01429661347212 0.135038655010863 no 2924 0.155220619751587 4110 1947235
SGTC_1939 st074455 53.6 µM -1.01478860399092 0.134924697437461 no 2925 0.155103303586001 4132 1644229
SGTC_2130 NSC 7 2.4545 µM -1.01721124225177 0.134364514822624 no 2926 0.154526474524596 4177 21448
SGTC_1990 st072050 59.8 µM -1.01732844674717 0.13433745438196 no 2927 0.154498604193216 4091 17233948
SGTC_1016 4226-1401 38 µM -1.01823345628271 0.134128629738644 no 2928 0.154283511747555 4074 2901613
SGTC_2714 st079313 56.9 µM -1.01959130050362 0.133815735122549 no 2929 0.153961166283004 4080 2939799
SGTC_286 k060-0067 22.9 µM -1.02317679758586 0.132991924616121 no 2930 0.153112130611204 4111 5985051
SGTC_3349 9149703 23.001 µM -1.02829767884154 0.131821406361112 no 2931 0.151904911297237 4135 4910494
SGTC_2404 5161160 200 µM -1.03324162774231 0.130698092726266 no 2932 0.150745418256369 4083 2831543
SGTC_654 1124-0271 80.9 µM -1.03557936935845 0.130169245821072 no 2933 0.150199210415636 4109 5403748
SGTC_2507 purpurin 79.67 µM -1.0357959304532 0.130120330139921 no 2934 0.150148678268368 4140 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2846 9008642 19.48 µM -1.03652228737859 0.129956357351395 no 2935 0.149979273632929 4200 2992898
SGTC_816 0325-0417 81.3 µM -1.03910421824615 0.12937465277944 no 2936 0.149378134680038 4142 68101
SGTC_287 k060-0039 29.6 µM -1.03960412077699 0.129262234427376 no 2937 0.14926193081987 4182 5861974
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.04305785175639 0.128487407346827 no 2938 0.14846074991829 4173 279621
SGTC_595 3909-8003 73.7 µM -1.04326829128088 0.128440300724352 no 2939 0.148412026236676 4213 699517
SGTC_3351 9150312 21.596 µM -1.04481382054044 0.128094703292955 no 2940 0.148054513028988 4056 4904905
SGTC_1548 st061468 90.8 µM -1.04489738174042 0.128076036507679 no 2941 0.14803520001535 4135 390799
SGTC_664 1222-0054 14.9 µM -1.04614583931273 0.127797367840466 no 2942 0.147746852074174 4116 6813991
SGTC_1300 1094-0077 113 µM -1.04639188035137 0.127742498674678 no 2943 0.147690070007445 4115 5532636
SGTC_1366 1683-0113 21.9 µM -1.04660571422358 0.127694825271614 no 2944 0.147640732676421 4146 708623
SGTC_2472 5377652 49.4 µM -1.05443182419975 0.125958529631098 no 2945 0.1458426292359 4213 1610903
SGTC_2378 9074213 121.43 µM -1.05843633245465 0.125076487797053 no 2946 0.144928281336837 4122 657714
SGTC_1045 1348-1485 165 µM -1.05954190163587 0.124833734418014 no 2947 0.14467652843066 4131 6810614
SGTC_977 1348-1378 135 µM -1.06320308911416 0.124032186711516 no 2948 0.143844930912239 4138 X977
SGTC_806 3966-4455 5.86 µM -1.06583534107867 0.123458134912277 no 2949 0.143249040996626 4148 714982
SGTC_920 mycophenolic acid 780.421 nM -1.06666010503124 0.123278650688031 no 2950 0.143062674230226 4157 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_714 4296-0578 26.1 µM -1.06752451624782 0.123090734787309 no 2951 0.142867524507637 4196 1589775
SGTC_3245 9134821 49.47 µM -1.07310598554838 0.121882202664259 no 2952 0.1416117828694 4183 17014901
SGTC_1157 4092-0394 27.6 µM -1.07373642108887 0.121746222833329 no 2953 0.141470416364417 4256 3659885
SGTC_472 calcifediol 10 µM -1.07597620106784 0.12126398268324 no 2954 0.1409689500824 4222 5283731 A vitamin D metabolite.
SGTC_1802 st050112 57.9 µM -1.0807165640555 0.120247783785482 no 2955 0.139911606327721 4166 4662563
SGTC_1702 st027038 51 µM -1.0842905371828 0.119485602991601 no 2956 0.139117999811871 4208 5521182
SGTC_578 3460-0051 92 µM -1.08543741831594 0.119241744532836 no 2957 0.138863983615477 4245 2876744
SGTC_2050 5263056 171 µM -1.08601455730266 0.119119161869087 no 2958 0.138736275907064 4174 763468 YGL055W OLE1
SGTC_2836 9010338 19.48 µM -1.08669333650899 0.118975104991877 no 2959 0.138586179932311 4158 2994051
SGTC_1923 st058458 19.1 µM -1.09008942269996 0.118256203355633 no 2960 0.13783687757367 4202 3534982
SGTC_3121 9125696 49.47 µM -1.09540357269149 0.117137448537114 no 2961 0.13666993480144 4298 1235365
SGTC_3217 9129673 49.47 µM -1.09753323997866 0.116691214283369 no 2962 0.136204179186427 4224 17248312
SGTC_953 1188-0045 9.7 µM -1.09951887680228 0.116276246092722 no 2963 0.13577090241885 4213 6144426
SGTC_486 niguldipine 82 µM -1.10007847162211 0.116159488559954 no 2964 0.135648966470486 4248 1236 A calcium channel blocker.
SGTC_2437 5741531 144.16 µM -1.10278278710433 0.115596415140304 no 2965 0.135060752416602 4222 2262990
SGTC_1091 telmisartan 47.6 µM -1.10849868615777 0.114412678097732 no 2966 0.133823253116458 4224 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1301 naphtanilide LB 4.81 µM -1.11051972913514 0.113996201412239 no 2967 0.133387565658061 4266 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3077 9117319 49.47 µM -1.11078437768067 0.113941745319393 no 2968 0.133330586236462 4178 17154678
SGTC_632 0781-2353 4.65 µM -1.12196622341667 0.111657797324567 no 2969 0.130938400718337 4287 6811515 YHR007C ERG11
SGTC_3241 9133421 49.47 µM -1.12347310990028 0.111352530357921 no 2970 0.130618307379796 4270 17018221
SGTC_13 0199-0087 65 µM -1.12512505115899 0.111018564952953 no 2971 0.130268023580395 4302 4589825
SGTC_1519 esterone 74 µM -1.12756308924015 0.110526989588136 no 2972 0.129752241175372 4176 698 A steroid.
SGTC_3146 9095609 49.47 µM -1.12790796912478 0.110457578508061 no 2973 0.129679393985907 4272 17173999
SGTC_3053 9095903 49.47 µM -1.12876274764142 0.110285679137731 no 2974 0.129498965675767 4330 17174018
SGTC_2849 9019321 12.99 µM -1.13100117812518 0.109836431085807 no 2975 0.129027297782538 4254 16489627
SGTC_2090 5301565 104.445 µM -1.13315674887222 0.109405055652036 no 2976 0.128574216769236 4226 2056344
SGTC_3002 9075603 71.4286 µM -1.13367602636066 0.109301319340925 no 2977 0.128465234683659 4161 20105405
SGTC_29 0299-0004 12.984 µM -1.13384827401385 0.109266924957331 no 2978 0.128429098797575 4115 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3000 9075062 71.4286 µM -1.13389047315723 0.109258499825165 no 2979 0.128420246903016 4184 17057871
SGTC_1407 3909-7909 12.3 µM -1.13494058134417 0.109048994201226 no 2980 0.128200107574184 4226 4411780
SGTC_2938 9059746 27.26 µM -1.13602549197054 0.108832848598078 no 2981 0.127972947825587 4230 6471769
SGTC_2040 5100729 123 µM -1.13647290094896 0.108743801544767 no 2982 0.127879350344857 4248 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_3274 9138298 49.47 µM -1.13685076192552 0.108668637332149 no 2983 0.127800339292171 4209 17015756
SGTC_1813 st051246 8.6015 µM -1.13736542063191 0.108566321391977 no 2984 0.12769277830176 4167 5291959
SGTC_613 3914-0030 117 µM -1.13837311249512 0.108366189455861 no 2985 0.12748235821283 3930 1145395
SGTC_2939 9044578 71.43 µM -1.13867192176085 0.108306895714594 no 2986 0.127420009054715 4154 2653634
SGTC_3279 9140807 49.47 µM -1.13880045699979 0.108281397212055 no 2987 0.127393195580988 4270 45595718
SGTC_751 0833-0568 350 µM -1.14101737968165 0.107842289276032 no 2988 0.126931345337176 4257 6954252
SGTC_3313 9133968 57.047 µM -1.14368488108622 0.107315636651657 no 2989 0.126377172834811 4232 1494643
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.14538106479757 0.106981719938369 no 2990 0.126025669298533 4234 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2774 tamoxifen 10.92 µM -1.14570496163085 0.106918041779413 no 2991 0.125958625097427 4214 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1513 0337-0559 19 µM -1.14632907866766 0.106795417407319 no 2992 0.125829507722164 4215 775073
SGTC_93 0109-0045 59.227 µM -1.14720472519889 0.106623544503391 no 2993 0.12564850957048 4361 88733
SGTC_2925 9010536 32.5 µM -1.15289507957415 0.105511498142242 no 2994 0.124476725962091 4157 2994177
SGTC_957 1187-1561 14.1 µM -1.15337574660915 0.105417948669839 no 2995 0.124378095947296 4195 1538454
SGTC_1703 st026983 48.3 µM -1.15350737702049 0.105392340664399 no 2996 0.124351095705262 4268 1104023
SGTC_3195 9113082 49.47 µM -1.15375115205111 0.105344927396077 no 2997 0.124301103003902 4242 17018038
SGTC_2314 7727897 200 µM -1.15531086196057 0.105041935227161 no 2998 0.123981574748905 4245 900724
SGTC_2800 7887935 81.82 µM -1.1580139392102 0.104518325143319 no 2999 0.123429174020431 4248 2961002
SGTC_2386 9075165 157.42 µM -1.15925819150622 0.104277938983193 no 3000 0.123175479013363 4228 16452277
SGTC_1125 tnp00248 1.32998 µM -1.15980095180914 0.104173204785575 no 3001 0.123064928245997 4315 24207736
SGTC_1398 3558-0053 112 µM -1.15985223979983 0.104163311900128 no 3002 0.123054485378325 4181 4532369
SGTC_669 0108-0021 26.2 µM -1.15989549779331 0.104154968441695 no 3003 0.123045678000076 4213 17201
SGTC_2931 9014674 55.67 µM -1.1619235607909 0.103764346012714 no 3004 0.122633257901366 4213 2996810
SGTC_3194 9111903 49.47 µM -1.16209646162878 0.10373109305005 no 3005 0.122598142280413 4289 17087251
SGTC_2232 chlorophetanol 41.5365 µM -1.16271531166559 0.103612136757069 no 3006 0.12247251358103 4314 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1713 st033146 12.748 µM -1.16283127842201 0.103589856468279 no 3007 0.122448981981785 4248 674619
SGTC_3348 9149464 3.537 µM -1.16425761955508 0.103316102826546 no 3008 0.122159812936029 4200 1951442
SGTC_871 0574-0004 149 µM -1.16457068220406 0.103256087947756 no 3009 0.122096408448645 4219 9551173
SGTC_108 0509-0257 621.132 µM -1.16542986385689 0.1030915107843 no 3010 0.12192251738547 4208 536624
SGTC_91 0417-1751 58.384 µM -1.16776957326334 0.10264430295016 no 3011 0.121449862207113 4360 6795624
SGTC_476 mead acid 10 µM -1.16856927369375 0.102491773469156 no 3012 0.121288606915541 4305 5312531 An omega 9 fatty acid.
SGTC_407 eburnamonine 100 µM -1.16978320857466 0.102260550744699 no 3013 0.121044111324065 4101 3195
SGTC_1435 4092-0789 56.7 µM -1.17217366327456 0.101806341537721 no 3014 0.120563669962677 4235 2248285
SGTC_274 sirtinol 40.1 µM -1.17426962733158 0.101409298220491 no 3015 0.120143522429895 4314 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_614 0462-0418 107 µM -1.17551677855681 0.101173583388695 no 3016 0.119894014254481 4037 5188303
SGTC_2352 9027995 87.8 µM -1.1763399515638 0.101018220439575 no 3017 0.119729528476344 4224 2997347
SGTC_2176 5809774 33.9695 µM -1.17753203180234 0.100793539545238 no 3018 0.119491610141255 4194 2870539
SGTC_1779 st039427 55 µM -1.17845191165039 0.100620411694166 no 3019 0.119308246370276 4247 1124498
SGTC_3269 9137823 49.47 µM -1.17910517410105 0.100497594899606 no 3020 0.119178149281176 4188 17682936
SGTC_3326 9140064 16.379 µM -1.17963611849693 0.100397855146702 no 3021 0.119072485602151 4194 1868434
SGTC_2026 5148700 152 µM -1.18208720337863 0.0999383467009287 no 3022 0.118585550697184 4243 79838
SGTC_2602 kawain 100 µM -1.1841043490205 0.0995613431115487 no 3023 0.118185879393201 4250 5369129
SGTC_1337 1486-1011 40.3 µM -1.18592831405173 0.099221340625693 no 3024 0.117825305226368 4242 X1337
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.18769301389009 0.0988931945297351 no 3025 0.117477188572662 4217 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1903 st060211 78.3 µM -1.18798113533138 0.0988396938115398 no 3026 0.117420421010569 4301 688960
SGTC_1845 st056753 3.01 µM -1.18805845292071 0.0988253404614306 no 3027 0.117405190702 4242 5375839
SGTC_525 k781-2675 26.7 µM -1.19135788287191 0.098214249973667 no 3028 0.116756559769891 4241 3651118 YDL195W SEC31
SGTC_837 0091-0265 12.5 µM -1.19702111961787 0.0971718174077745 no 3029 0.115649161519191 4252 759367
SGTC_1669 st015249 58.4 µM -1.20094683763555 0.0964539901415307 no 3030 0.114885911997305 4373 722793
SGTC_2694 st077685 81.9 µM -1.20282043580251 0.0961127748353741 no 3031 0.114522907432938 4213 2838096
SGTC_339 3091-4833 71.4 µM -1.20486532681446 0.0957413778634292 no 3032 0.114127647946942 4144 3240077
SGTC_1280 0880-0253 10.1 µM -1.20490314845764 0.0957345185836811 no 3033 0.11412034651881 4271 6836607
SGTC_1325 1431-0015 227 µM -1.20577022773989 0.0955773654491066 no 3034 0.113953049024259 4298 1103340
SGTC_1511 0906-3109 28.5 µM -1.20610248937549 0.0955171952766825 no 3035 0.113888987564197 4295 2882180
SGTC_2775 cyproheptadine 69.59 µM -1.20889999242744 0.0950116929249186 no 3036 0.113350634539926 4297 2913 A selective serotonin reuptake inhibitor.
SGTC_1844 rapamycin 4 nM -1.21036719449652 0.0947473619993184 no 3037 0.113069012100984 4170 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_17 0960-0276 49.807 µM -1.21226584476914 0.0944061063838405 no 3038 0.11270531688015 4279 6821114
SGTC_1837 st055472 66.5 µM -1.21250586313672 0.0943630310788483 no 3039 0.112659399798802 4361 676091
SGTC_627 1391-0720 175 µM -1.21384107536708 0.094123669503098 no 3040 0.112404208845643 4260 997839
SGTC_573 3702-0553 84.7 µM -1.21419212676594 0.0940608114561787 no 3041 0.112337183156655 4245 1222756
SGTC_2446 5162541 200 µM -1.21767336764119 0.0934391482965757 no 3042 0.111674060770194 4257 1549321
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.2214502703995 0.0927681254073258 no 3043 0.110957791753612 4324 5106787 A p450 inhibitor.
SGTC_1147 3809-1045 12.3 µM -1.22225443656776 0.0926257146277281 no 3044 0.110805711887472 4296 325925
SGTC_1563 conessine 56.1 µM -1.22445880799678 0.0922361690545254 no 3045 0.110389598189338 4384 441082 An anti-amoebic, histamine inhibitor.
SGTC_1682 st012968 530 nM -1.22562463064933 0.0920306415519345 no 3046 0.110169982282079 4312 24207270
SGTC_2671 danthron 100 µM -1.22701578395591 0.0917858336049287 no 3047 0.109908329260463 4299 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2328 6201408 200 µM -1.23013986167378 0.0912378332057054 no 3048 0.10932236761915 4304 2890418
SGTC_2773 thioridazine 9.09 µM -1.23309833298934 0.0907211221395279 no 3049 0.108769539675036 4291 5452 An antipsychotic.
SGTC_1616 st002734 56.1 µM -1.23742347674885 0.0899696281563384 no 3050 0.107964953736402 4259 4026101
SGTC_933 2914-0560 114 µM -1.23825172974973 0.089826248409033 no 3051 0.107811367965306 4332 463887
SGTC_1659 st012954 42.1 µM -1.23988924655557 0.0895432761047999 no 3052 0.10750818092195 4272 24207262
SGTC_499 genistein 192 µM -1.24247369735922 0.0890980177701001 no 3053 0.107030919591538 4421 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_197 4544-0043 41.561 µM -1.24277055179511 0.0890469803272344 no 3054 0.106976198539423 4333 896523
SGTC_2826 7992541 19.48 µM -1.24459433207325 0.088733899754102 no 3055 0.106640452433828 4323 2985066
SGTC_2611 pyromycin 23.93 µM -1.25435584505716 0.0870721066985588 no 3056 0.104856347050762 4300 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1972 st070201 17.4 µM -1.25848318445558 0.0863765051247038 no 3057 0.104108532407722 4341 2829099
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.25855928392444 0.086363718821383 no 3058 0.104094780674016 4318 688803
SGTC_2033 5192550 145 µM -1.25872219877144 0.0863363504762108 no 3059 0.10406534519068 4338 182073
SGTC_1194 1488-0194 225 µM -1.26219573114297 0.0857543681073762 no 3060 0.103439182209042 4292 1391452
SGTC_1864 st057645 30.4 µM -1.2622265715851 0.0857492140475655 no 3061 0.10343363497265 4374 688666
SGTC_2204 7233102 200 µM -1.26708277755734 0.0849405340098893 no 3062 0.102562846509562 4268 2172480
SGTC_167 3672-0051 66.205 µM -1.2686817494879 0.0846755201106625 no 3063 0.10227729712988 4249 3237971
SGTC_1898 st060199 18.6 µM -1.26879612894325 0.08465658663141 no 3064 0.102256893074058 4316 688866
SGTC_2152 5568786 200 µM -1.26896087595195 0.0846293212823917 no 3065 0.102227509196042 4362 5399883
SGTC_2811 7967822 32.47 µM -1.27497695678822 0.0836381761271218 no 3066 0.101158699110632 4382 2232244
SGTC_1022 4477-0945 21.3 µM -1.27716480427746 0.0832799005812626 no 3067 0.100772034915356 4297 4648966
SGTC_450 aminopyrene 156 nM -1.27769523664367 0.0831932125478571 no 3068 0.100678452714378 4298 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1372 2752-0194 270 µM -1.27804617803338 0.0831358958520867 no 3069 0.100616572287365 4289 823334
SGTC_3268 9137683 49.47 µM -1.27913891622442 0.0829576170811907 no 3070 0.100424070781836 4429 1953228
SGTC_191 3914-0123 66.505 µM -1.28011502729745 0.0827986091801919 no 3071 0.100252342188823 4367 3144412
SGTC_2302 7771753 200 µM -1.28239612854831 0.082427913463602 no 3072 0.0998518608030219 4342 2203047
SGTC_1921 5740136 50 µM -1.28338557054928 0.0822675109673329 no 3073 0.0996785133158981 4291 1774243
SGTC_236 1509-0011 5.31 µM -1.28910220032374 0.0813453643785889 no 3074 0.0986812793603686 4396 3107280
SGTC_1660 st012960 28.1 µM -1.28918929158598 0.0813313762791921 no 3075 0.0986661434566692 4385 24207266
SGTC_2964 9083345 53.42 µM -1.2912696221617 0.0809977845949396 no 3076 0.0983051002447896 4336 17741579
SGTC_690 glyoxal 20.3 µM -1.29147142817106 0.0809654789971943 no 3077 0.0982701281854691 4163 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1636 st007707 68.9 µM -1.29682195710527 0.0801124965324192 no 3078 0.0973462269832522 4374 403051
SGTC_3328 9140624 29.0385 µM -1.29743714201263 0.0800148606836161 no 3079 0.0972404099153872 4378 4904392
SGTC_2153 5569715 200 µM -1.29837719662619 0.0798658386565628 no 3080 0.0970788755425349 4394 2054701
SGTC_56 0957-0365 83.25 µM -1.30194777960596 0.0793017248165768 no 3081 0.0964671187859774 4323 6752360
SGTC_2231 micatex 6.853 µM -1.30298972873594 0.0791376778891842 no 3082 0.0962891341072481 4387 20737 An antifungal of unknown mechanism.
SGTC_1204 4049-0315 18.3 µM -1.30512357876735 0.0788025216945399 no 3083 0.0959253855416209 4404 588402
SGTC_719 2810-4230 27.3 µM -1.30588422172078 0.0786833105908272 no 3084 0.0957959665246454 4385 721079
SGTC_1250 0485-0349 40.2 µM -1.30889410737825 0.0782129289865963 no 3085 0.0952851114747817 4385 6842794 YDL195W SEC31
SGTC_1647 st011722 22.4 µM -1.31166842826538 0.077781252954076 no 3086 0.0948160168685463 4332 2854783
SGTC_1675 st018485 24.5 µM -1.31203990496447 0.0777235898381218 no 3087 0.0947533353317866 4394 3323024
SGTC_1725 st036284 20.55 µM -1.31298467157018 0.0775770830177227 no 3088 0.0945940566857562 4414 707914
SGTC_3130 9127414 49.47 µM -1.3139205337855 0.0774321638438245 no 3089 0.094436473909569 4392 1494646
SGTC_233 rapamycin 362 pM -1.31456882439618 0.0773318960199964 no 3090 0.0943274266883763 4364 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1785 bathophenanthroline 24 µM -1.31704858570448 0.0769492738986114 no 3091 0.0939111696426123 4294 72812 An iron chelator.
SGTC_372 0155-0182 15.9 µM -1.32167616005689 0.0762390993725094 no 3092 0.0931380052424558 4262 771486
SGTC_2339 9000433 200 µM -1.32318241193413 0.0760090204981127 no 3093 0.0928873617519567 4380 2988954
SGTC_2992 9074591 71.4286 µM -1.32405779164264 0.0758755499943178 no 3094 0.0927419260397178 4339 17741321
SGTC_2129 girgensonine 121.053 µM -1.32539826374399 0.0756715121526357 no 3095 0.0925195462921864 4388 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_192 3455-0609 60.9 µM -1.32653112928844 0.0754994009407843 no 3096 0.0923319155487072 4448 3769639
SGTC_1550 gossypolone 36.6 µM -1.3269638716758 0.0754337351151239 no 3097 0.0922603170138905 4421 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.32723558003721 0.0753925273994888 no 3098 0.0922153830511034 4404 2374 Ca(2+)-ATPase inhibitor.
SGTC_2863 9028737 58.44 µM -1.32769697641846 0.0753225906104215 no 3099 0.0921391164114704 4376 6460917
SGTC_2418 pentamidine 31.67 µM -1.33019043279734 0.0749454970349809 no 3100 0.091727767778166 4335 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_560 2332-1943 155 µM -1.33056273900399 0.0748893157242155 no 3101 0.0916664648755431 4380 21177716
SGTC_71 0417-1750 47.813 µM -1.33729785450435 0.0738785204832831 no 3102 0.090562715529392 4366 6811472
SGTC_3003 9075612 71.4286 µM -1.33767417311218 0.0738223522487446 no 3103 0.0905013368091817 4410 6501993
SGTC_843 0310-0051 143 µM -1.34153100741021 0.0732485721402614 no 3104 0.0898740546806098 4412 2065037
SGTC_1495 4469-0029 237 µM -1.34371264233488 0.0729255251932265 no 3105 0.0895206637897606 4412 793680
SGTC_2622 2-methoxyxanthone 59.94 µM -1.34434359273319 0.0728323004314694 no 3106 0.0894186525560937 4375 71034 A hepatoprotective.
SGTC_2408 sulbentine 18.36 µM -1.34720350782567 0.0724108833371888 no 3107 0.0889573492606627 4284 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_574 1315-0397 40 µM -1.34771368619516 0.0723359037694777 no 3108 0.0888752442086877 4375 6794277
SGTC_3035 9091303 49.47 µM -1.35048351827394 0.0719298667431129 no 3109 0.088430468475115 4471 25237002
SGTC_1375 2910-0797 186 µM -1.35416748734164 0.0713925348618321 no 3110 0.0878414745889114 4394 742508
SGTC_3047 9092122 49.47 µM -1.35439430475226 0.0713595529568368 no 3111 0.0878053068174489 4373 17173831
SGTC_310 1273-0058 1.06 µM -1.35481471195071 0.0712984517620095 no 3112 0.0877382990498062 4164 2734232
SGTC_2124 5246320 200 µM -1.3586576958851 0.0707417797702935 no 3113 0.0871275416471266 4415 579342
SGTC_1361 1608-0041 5.61 µM -1.35903531478366 0.0706872608305842 no 3114 0.0870676992111219 4384 X1361
SGTC_2553 4-methylesculetin 85.09 µM -1.36031185778715 0.0705031982712884 no 3115 0.0868656287773821 4427 5319502
SGTC_2682 pyrogallin 40.03 µM -1.36497439688272 0.0698340439916281 no 3116 0.0861305486238638 4418 822798 An ATP competetive kinase inhibitor.
SGTC_385 1494-0393 12.4 µM -1.36821136065878 0.0693723663194292 no 3117 0.0856229632806828 4382 3090647
SGTC_1489 4065-0444 182 µM -1.36836288969287 0.0693508119638863 no 3118 0.0855992571453389 4430 2877968
SGTC_371 0195-0006 7.36 µM -1.37711205284611 0.0681150078087902 no 3119 0.0842388034260372 4263 3928593
SGTC_225 nsc-122657 1.016 µM -1.384728779339 0.0670530609314238 no 3120 0.0830677077982854 4440 275685
SGTC_2716 st080858 38.6235 µM -1.38474223700564 0.0670511960207073 no 3121 0.0830656495316139 4403 5296050
SGTC_3191 9110352 49.47 µM -1.38797128035289 0.0666048862778298 no 3122 0.0825728953012517 4388 17122424
SGTC_1657 st012939 43.4 µM -1.39136308908244 0.0661385592857169 no 3123 0.0820576757733327 4432 24207257
SGTC_2471 5466956 24.79 µM -1.39292850352934 0.0659241911688011 no 3124 0.0818207060238437 4423 724419
SGTC_1767 st044992 70.3 µM -1.39642066369342 0.0654479147904894 no 3125 0.0812939280636434 4479 9600693
SGTC_2552 juarezic acid 87.02 µM -1.39683210951843 0.0653919761586514 no 3126 0.0812320320238221 4379 1549512
SGTC_2618 avocadyne 43.43 µM -1.39748706746197 0.0653030070438304 no 3127 0.0811335764862366 4355 3015189
SGTC_1743 st037606 46.3785 µM -1.4026987744055 0.0645983947523762 no 3128 0.0803533414761046 4397 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3011 9081274 71.4286 µM -1.40282010293726 0.0645820619969549 no 3129 0.0803352453760079 4434 6625322
SGTC_484 loperamide 105 µM -1.40358989960349 0.0644785098165528 no 3130 0.0802205022706554 4516 3955 An opioid-receptor agonist.
SGTC_406 estrone 100 µM -1.40722820836241 0.0639908333163729 no 3131 0.0796798648099444 4416 5870 A steroid.
SGTC_1838 st055369 84.5 µM -1.40840820098631 0.0638332853285613 no 3132 0.0795051161099999 4425 676036
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.40979765042702 0.0636481584565141 no 3133 0.0792997203036494 4454 4174840
SGTC_1047 2043-3044 82 µM -1.41548487856485 0.0628947572433837 no 3134 0.0784631894536622 4422 669592
SGTC_15 0266-0086 27.098 µM -1.41950876746705 0.0623659128934971 no 3135 0.077875371305229 4514 1712902 YIL048W NEO1
SGTC_2388 9080168 200 µM -1.42409757445951 0.0617670626873804 no 3136 0.0772091142336977 4465 15943073
SGTC_1425 4048-4433 7.33 µM -1.42574115828105 0.0615536662733727 no 3137 0.0769715356669572 4508 23734946
SGTC_2053 5265679 138 µM -1.42748652683451 0.061327685333504 no 3138 0.0767198529868648 4368 764595
SGTC_1486 3970-0793 4.53 µM -1.42812826821432 0.0612447592692354 no 3139 0.0766274711960852 4483 2844330
SGTC_386 1509-0011 3.07 µM -1.43080306003009 0.0609000649706855 no 3140 0.0762433329261235 4465 3107280
SGTC_2561 acetosyringone 100 µM -1.43484215085983 0.060382433427031 no 3141 0.0756660417502877 4399 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2624 nerol 100 µM -1.4374919605145 0.0600447205060742 no 3142 0.0752891277823248 4372 637566 A natural product oil.
SGTC_1970 st070122 35.8 µM -1.44097782194695 0.0596027092003417 no 3143 0.0747954742355942 4471 102928
SGTC_2926 9010726 65.15 µM -1.44355772887106 0.0592772190520174 no 3144 0.0744317113654506 4445 2994293
SGTC_145 3737-0113 38.366 µM -1.44926620335365 0.0585619724380904 no 3145 0.0736316277329669 4444 6849351
SGTC_3234 9132280 49.47 µM -1.45135164718485 0.0583023718194558 no 3146 0.073340983294938 4486 17612295
SGTC_2332 7982454 138.89 µM -1.4545459273558 0.0579064944935813 no 3147 0.0728975049855441 4369 2981748
SGTC_138 0850-0259 40.9225 µM -1.46128750563513 0.0570779265508344 no 3148 0.0719682786295813 4408 6813004
SGTC_2736 butenafine 14.65 µM -1.46312817200781 0.0568533306508892 no 3149 0.0717161552196466 4419 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2178 5812956 200 µM -1.46428402117559 0.0567126514535549 no 3150 0.0715581806095044 4449 5403383
SGTC_22 0964-0034 14.468 µM -1.4664868453508 0.0564453036154245 no 3151 0.0712578511720954 4483 138402
SGTC_2640 pentamidine 10.38 µM -1.47166080997829 0.0558212667646156 no 3152 0.0705562477425601 4442 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2173 5763948 167 µM -1.47585740902137 0.0553191197592136 no 3153 0.0699910876193121 4451 2867177
SGTC_675 1309-0189 238 µM -1.47736634913221 0.0551394408583751 no 3154 0.0697887307075769 4493 4246530
SGTC_34 0469-0683 81.75 µM -1.47958217111894 0.0548764250836661 no 3155 0.0694923936975026 4454 3690923
SGTC_149 3970-0822 46.1 µM -1.48259799264902 0.0545200445310343 no 3156 0.0690906253964918 4453 3114250 YBL034C STU1
SGTC_1870 st057514 26.5 µM -1.48978342545421 0.0536783148473069 no 3157 0.0681405952764997 4489 5393161
SGTC_1246 0422-0085 105 µM -1.49321256548993 0.053280256818404 no 3158 0.0676907769772364 4492 264295
SGTC_1146 3579-1023 7 µM -1.50128577981733 0.0523523476010856 no 3159 0.0666408306927439 4503 X1146
SGTC_2419 paclitaxel 166.5 µM -1.50664883182007 0.0517430611353307 no 3160 0.0659503467996495 4442 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1376 2910-0861 41.3 µM -1.51251900864187 0.0510826365507393 no 3161 0.0652009403204552 4442 1112859
SGTC_1940 st075990 51.1 µM -1.51448414616691 0.0508630534647827 no 3162 0.0649515458974801 4542 1084979
SGTC_413 propylparaben 100 µM -1.51924035567984 0.0503347079759186 no 3163 0.0643510033706853 4493 7175 A pharmaceutical preservative.
SGTC_3208 9114115 49.47 µM -1.51931749476258 0.0503261751308616 no 3164 0.0643412990879936 4465 650895
SGTC_252 miconazole 1.30953 nM -1.5213490425772 0.0501018673710403 no 3165 0.0640861346173508 4424 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_52 0329-0193 875 nM -1.52345396734845 0.049870299418193 no 3166 0.063822584500609 4535 3739292
SGTC_704 1310-0270 142 µM -1.53204877499597 0.0489336098489002 no 3167 0.0627551995285826 4493 5718033
SGTC_314 1671-0008 2.74 µM -1.53307872680798 0.0488223118588728 no 3168 0.0626282292544898 4387 3913060
SGTC_3294 9122953 26.2835 µM -1.53379618394869 0.0487449020795567 no 3169 0.0625399010482873 4499 16459826
SGTC_3113 9123498 49.47 µM -1.53425704476689 0.0486952294356506 no 3170 0.0624832143980989 4610 8897275
SGTC_2267 7931562 200 µM -1.53881914163059 0.04820569588998 no 3171 0.0619242277282622 4463 934880
SGTC_2857 9024691 58.44 µM -1.54169125310028 0.0478995304478103 no 3172 0.0615743192449742 4537 16478292
SGTC_715 0868-0130 184 µM -1.54494192270611 0.0475548909729542 no 3173 0.0611801559346567 4562 2876258
SGTC_151 3013-0144 2.285 µM -1.55456562092053 0.0465462097939486 no 3174 0.0600247784466908 4278 906558 YHR107C CDC12
SGTC_401 neomycin 50 µM -1.55470525626496 0.0465317016764736 no 3175 0.0600081410972158 4528 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2658 polymyxin b sulfate 77.05 µM -1.55480966722661 0.0465208557453475 no 3176 0.0599957030418805 4549 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1630 st005209 31.3 µM -1.55873012697504 0.0461150751972622 no 3177 0.0595301340337729 4513 3367314
SGTC_1935 st074532 41.6 µM -1.55971777419134 0.0460133000295746 no 3178 0.0594132949744631 4482 2829742
SGTC_536 3852-0578 10.6 µM -1.56425623603489 0.0455479377361168 no 3179 0.0588787026569538 4553 2869208
SGTC_405 ebelactone b 50 µM -1.56860568887345 0.0451055144554796 no 3180 0.0583699230327138 4474 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_993 3909-8757 62.7 µM -1.56892502393787 0.0450731686654162 no 3181 0.0583327051258971 4484 4288324 YLR208W SEC13
SGTC_1863 st057641 20.1 µM -1.57766934119959 0.0441946785980184 no 3182 0.0573207965890814 4584 3921635
SGTC_2841 9004761 38.96 µM -1.5845436391512 0.0435137928288979 no 3183 0.0565350295546554 4480 2991039
SGTC_1574 spiramycin 23.7 µM -1.58861491878504 0.0431145492317181 no 3184 0.0560736789679227 4506 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1662 st014054 52 µM -1.59081089781061 0.0429004355596286 no 3185 0.0558260698266532 4620 2838777
SGTC_2540 epiandrosterone 100 µM -1.59089434813059 0.0428923159140825 no 3186 0.0558166773696768 4563 441302 A steroid.
SGTC_756 0508-1999 28.3 µM -1.59740146170522 0.0422629934199408 no 3187 0.0550881234276274 4560 6753853
SGTC_651 3253-0966 34.4 µM -1.60294157209778 0.0417330995159118 no 3188 0.0544737771576679 4567 781462
SGTC_299 1273-0059 1.44 µM -1.61637766302908 0.0404703108121716 no 3189 0.0530063423737839 4322 2848077
SGTC_721 1187-1332 279 µM -1.61893940027603 0.0402331038996119 no 3190 0.0527301512051888 4557 25730
SGTC_2960 9079389 5.97 µM -1.62003498203794 0.0401320026431348 no 3191 0.0526123812773203 4514 16457355
SGTC_1104 tacrolimus 29.8 µM -1.62983180631123 0.0392370887891557 no 3192 0.051568524766239 4610 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_643 k048-0106 28.4 µM -1.63256032518027 0.0389907581406129 no 3193 0.0512807506419761 4587 6763920
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.63471847778934 0.0387968132755602 no 3194 0.0510540385705059 4634 688664
SGTC_712 r015-0009 80.6 µM -1.63702098226255 0.038590763200952 no 3195 0.0508130427331123 4590 6813872 YLR060W FRS1
SGTC_1316 1272-0050 65.9 µM -1.64138717014645 0.0382024840742312 no 3196 0.0503585357060069 4564 7340392
SGTC_2274 7947094 46.08 µM -1.64242831429005 0.0381103685142638 no 3197 0.0502506355247722 4527 2971028
SGTC_903 1134-0042 114 µM -1.64283413183592 0.0380745127820716 no 3198 0.0502086280961268 4576 701009
SGTC_375 3970-0961 9.27 µM -1.64396019505505 0.0379751643274976 no 3199 0.0500922123979531 4542 2898222
SGTC_3089 9117425 49.47 µM -1.64486790878292 0.0378952340984681 no 3200 0.0499985270514685 4540 9401657
SGTC_2401 5128683 200 µM -1.64628734187282 0.0377705188031655 no 3201 0.0498523071609533 4544 708373
SGTC_867 0518-0118 155 µM -1.64645677208082 0.037755654604872 no 3202 0.0498348764772634 4550 6848158
SGTC_2055 5235184 200 µM -1.64988248284729 0.0374561380990292 no 3203 0.0494834870816065 4564 2836034
SGTC_14 0354-0009 295 µM -1.65463589346218 0.0370437554688479 no 3204 0.0489991890201574 4664 1713507
SGTC_562 3772-2733 112 µM -1.65699363449283 0.0368405904767566 no 3205 0.0487603810270023 4548 2876874 YIL048W NEO1
SGTC_2869 9037858 32.47 µM -1.65706590814405 0.0368343771252751 no 3206 0.0487530753825533 4534 27187042
SGTC_2269 7935389 174.42 µM -1.66113333586095 0.0364860798857341 no 3207 0.0483433353199026 4586 97605
SGTC_288 1315-0019 35.1 µM -1.66664900670141 0.0360180781099477 no 3208 0.0477921090614837 4607 6811474
SGTC_3272 9137413 49.47 µM -1.67117783036356 0.0356374958277025 no 3209 0.0473432789251168 4519 17614870
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.67162098011522 0.0356004331935832 no 3210 0.047299542501455 4595 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2867 9039098 71.43 µM -1.67192924136694 0.0355746705379981 no 3211 0.0472691379259605 4560 6463460
SGTC_2417 cerulenin 830 nM -1.67839819355854 0.035037550113631 no 3212 0.0466346950192391 4579 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3249 9135183 49.47 µM -1.68642014374108 0.0343807457466269 no 3213 0.0458574521257455 4542 4902779
SGTC_848 0368-0089 85.6 µM -1.68769819328125 0.0342770446556184 no 3214 0.0457345894012097 4590 762535
SGTC_533 1222-0222 6.71 µM -1.68888629120556 0.0341808729656281 no 3215 0.0456206114348222 4607 3982874
SGTC_2013 4024628 200 µM -1.69200721008535 0.0339293035428584 no 3216 0.0453222994515793 4587 5230760
SGTC_2673 kobusone 100 µM -1.69292660805244 0.0338554842540723 no 3217 0.0452347189414957 4685 6710676 An epoxy ketone and protein crosslinker.
SGTC_1963 st076565 50.3 µM -1.69557214448504 0.0336438085106183 no 3218 0.0449834683856837 4611 4914280
SGTC_118 0083-0097 135.343 µM -1.70273415142092 0.0330762195113923 no 3219 0.0443089153454413 4572 5207356
SGTC_752 1896-0090 130 µM -1.70729001940015 0.0327192898155676 no 3220 0.0438840801334736 4609 772567
SGTC_2729 fluphenazine 10.66 µM -1.71559393546308 0.0320768902140186 no 3221 0.0431181946299281 4564 3372 An atypical antipsychotic.
SGTC_1822 st052468 42 µM -1.71618131408875 0.0320318471261719 no 3222 0.0430644310677708 4610 2873678
SGTC_3254 9136651 49.47 µM -1.72990665031092 0.0309941021052963 no 3223 0.0418234774596133 4568 16454030
SGTC_3031 9088762 49.47 µM -1.73024360593092 0.0309689796569704 no 3224 0.0417933802419204 4575 205253
SGTC_1429 4049-0205 9.46 µM -1.73193996209776 0.0308427600280147 no 3225 0.0416421263055447 4647 22774478
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.73579571639881 0.0305574509637815 no 3226 0.0412999809021953 4624 6708784 An antioxidant flavonoid
SGTC_2976 9009005 19.48 µM -1.73894915822294 0.0303257381113832 no 3227 0.04102185313897 4575 2993148
SGTC_802 4112-3352 742 µM -1.74449182382046 0.0299219959009228 no 3228 0.0405366829403972 4623 704594
SGTC_1090 efavirenz 20.7 µM -1.76321601864923 0.0285909119682582 no 3229 0.0389320315469005 4621 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2779 methotrexate 400 µM -1.76953309406178 0.0281531005401468 no 3230 0.0384024765189075 4597 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1534 6-azauridine 81.6 µM -1.77585627198131 0.0277204701590125 no 3231 0.0378783049708687 4649 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_998 3996-0085 177 µM -1.77710209190469 0.0276358880784943 no 3232 0.0377757220321715 4636 715391
SGTC_596 1155-0152 116 µM -1.77931076995108 0.0274864636980159 no 3233 0.0375944131157139 4645 280313
SGTC_3304 9125678 46.087 µM -1.78049444123911 0.0274066620405801 no 3234 0.0374975391220913 4572 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_599 1935-0052 86.5 µM -1.78060379763497 0.0273992991266514 no 3235 0.0374885994749408 4610 9557311
SGTC_1200 1643-0193 18.4 µM -1.78080806120766 0.027385550575945 no 3236 0.0374719060345731 4635 5403974
SGTC_985 1493-0307 8.71 µM -1.78486100359487 0.027113942956074 no 3237 0.0371419326875704 4650 3278274
SGTC_123 0083-0120 66.675 µM -1.79957631710292 0.0261466241088291 no 3238 0.0359637817018711 4603 16001701
SGTC_43 0570-0105 72.5 µM -1.81195057226367 0.0253556910789782 no 3239 0.0349969170891443 4593 1114046 YDL195W SEC31
SGTC_2342 7990637 118.86 µM -1.81438377352405 0.0252025483805318 no 3240 0.0348093310729752 4613 2033102 YER133W GLC7
SGTC_3110 9122132 49.47 µM -1.81547672497892 0.0251340120547649 no 3241 0.0347253398127272 4641 918317
SGTC_1857 st056007 79.3 µM -1.81611427731385 0.0250941048858821 no 3242 0.0346764220184036 4625 619834
SGTC_830 4076-0286 57.8 µM -1.8180480001151 0.0249733894857736 no 3243 0.0345283983430485 4676 6866659
SGTC_2089 5281248 129.67 µM -1.83147996684009 0.0241482474247791 no 3244 0.0335144675766753 4620 2737878
SGTC_2441 5730946 39.09 µM -1.83537955742351 0.0239130246912128 no 3245 0.0332247352559571 4652 1774275
SGTC_390 dec-rvkr-cmk 16.7 µM -1.83697167373377 0.0238175436129987 no 3246 0.0331070385891351 4668 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1412 3909-8563 178 µM -1.84396755553947 0.0234017821697738 no 3247 0.0325939343214262 4715 23767530
SGTC_315 k915-0449 187 µM -1.85160402088302 0.022954939529659 no 3248 0.0320413526205856 4663 20970215 YNL149C PGA2
SGTC_1286 0929-0070 131 µM -1.85248755298802 0.0229037071807936 no 3249 0.0319779216411387 4683 1420408
SGTC_653 0203-0016 55.2 µM -1.85531020721548 0.0227406782179038 no 3250 0.0317759707239519 4687 295302
SGTC_1936 st074407 74.3 µM -1.85612970317461 0.0226935299064257 no 3251 0.0317175364426392 4657 809813
SGTC_2117 5521686 200 µM -1.85945779407881 0.0225028997104841 no 3252 0.0314811381865751 4643 803312
SGTC_2429 5902844 64.44 µM -1.88068117881363 0.0213187420725893 no 3253 0.0300076507203804 4641 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2478 5763493 32.33 µM -1.88465611680729 0.0211029229869867 no 3254 0.0297381403280681 4604 1365576 YLR208W SEC13
SGTC_3025 9087895 49.47 µM -1.88877506876062 0.0208812377174369 no 3255 0.0294609873996611 4662 17173641
SGTC_2776 terbinafine 19.92 µM -1.88893959301942 0.0208724239897755 no 3256 0.0294499617042991 4647 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_219 mitoxanthrone 164.414 µM -1.893308627593 0.0206395201185882 no 3257 0.0291584192436128 4631 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2980 9014342 25.29 µM -1.89749997351475 0.0204181609664761 no 3258 0.0288809911390651 4657 2996599
SGTC_541 4513-1321 94 µM -1.90131490091508 0.0202184340122364 no 3259 0.0286303892312689 4637 747515
SGTC_1603 st002045 67.8 µM -1.91279478035138 0.019627380500968 no 3260 0.0278871648214376 4660 5887985
SGTC_1463 k081-0032 34.1 µM -1.92898737788487 0.0188186749798051 no 3261 0.0268662146043557 4179 977755
SGTC_1395 3486-0190 4.35 µM -1.92950589795139 0.0187932541506864 no 3262 0.0268340442958727 4658 6748079
SGTC_1768 st044301 37.178 µM -1.95033730854067 0.0177958731339805 no 3263 0.0255679643282321 4679 3931349
SGTC_2012 4023501 200 µM -1.95072830401804 0.0177775930588364 no 3264 0.0255446872673626 4649 3477460
SGTC_2390 9097792 176.6 µM -1.95188695431987 0.0177235171306004 no 3265 0.0254758137345014 4694 4497149
SGTC_2322 7413319 38.22 µM -1.95753867667989 0.0174617505372047 no 3266 0.0251420845811832 4600 1840400
SGTC_1937 st074714 47.2 µM -1.96443687459384 0.0171467317079781 no 3267 0.0247397250419862 4636 17250970
SGTC_1596 piperlongumine 63 µM -1.97514259947917 0.0166674561981111 no 3268 0.0241259838487944 4682 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3322 9139058 2.11 µM -1.98045323270493 0.0164339930896599 no 3269 0.0238263117273091 4695 4908926 YPR165W RHO1
SGTC_1419 3993-2473 62.6 µM -1.98593553817448 0.0161959256737762 no 3270 0.0235202410177385 4733 704026
SGTC_1386 3228-0095 33.8 µM -1.98938172843804 0.0160477932743695 no 3271 0.0233295424248091 4679 870181
SGTC_853 0419-0306 21 µM -1.99248882130825 0.01591523370774 no 3272 0.0231587252512255 4731 762713
SGTC_742 0kpi-0133 140 µM -2.00239397523959 0.0154988936660496 no 3273 0.022621187969521 4702 2728852
SGTC_1718 roemerine 11.9335 µM -2.00594627818059 0.0153518756868457 no 3274 0.0224309899965971 4302 235224 An aporphine alkaloid with mutagenic activity.
SGTC_849 0386-0493 241 µM -2.01211759417369 0.0150993121432529 no 3275 0.0221037712137917 4698 726119
SGTC_1518 st038567 90.8 µM -2.01729520300267 0.0148901789157185 no 3276 0.0218323579657059 4645 77966
SGTC_3028 9087778 49.47 µM -2.02805907685913 0.0144633652837959 no 3277 0.0212771094574178 4659 17217395
SGTC_3292 9120825 59.784 µM -2.03518063395019 0.0141868036497473 no 3278 0.020916350462835 4674 24824900
SGTC_720 r052-1644 49.9 µM -2.05397723873795 0.0134786311998318 no 3279 0.0199889473704778 4691 1422863 YOR257W CDC31
SGTC_736 0958-0254 92.6 µM -2.05636426259654 0.0133909202864832 no 3280 0.0198737091525077 4715 6812352
SGTC_2265 7929201 200 µM -2.05678161359241 0.0133756355019566 no 3281 0.0198536187352134 4681 1265108
SGTC_881 0833-0569 170 µM -2.06956095466549 0.0129148519300393 no 3282 0.0192467388307191 4703 5418700
SGTC_2064 5220758 200 µM -2.08499010678126 0.0123768711419977 no 3283 0.0185350992852003 4699 788518
SGTC_746 1095-0025 46.6 µM -2.08739841682886 0.012294674548846 no 3284 0.0184260674851391 4711 6749286
SGTC_1439 4092-1168 46 µM -2.11887383303266 0.0112631243366352 no 3285 0.0170505654454042 4725 2886240
SGTC_2887 9044784 58.44 µM -2.12860743545458 0.0109597414393255 no 3286 0.0166433764139135 4638 6465546
SGTC_2784 7567673 72.73 µM -2.12981870639222 0.0109224898120189 no 3287 0.0165932918436868 4641 3471247
SGTC_1401 3807-4679 7.6 µM -2.13575773704365 0.0107414301054097 no 3288 0.0163495827945995 4659 3291456
SGTC_734 2023-0417 80 µM -2.15858346450964 0.0100696596859933 no 3289 0.015441248368191 4708 3935732
SGTC_1038 k292-0204 154 µM -2.17703237300917 0.00955378756891645 no 3290 0.0147390760575989 4681 4454212
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -2.19576522629754 0.00905376502388321 no 3291 0.014054375907006 4712 3256 An antibiotic and ribosome inhibitor.
SGTC_765 1319-0117 244 µM -2.21160765022833 0.00864893485148698 no 3292 0.0134968931836531 4710 3487746 YGL099W LSG1
SGTC_1249 0481-0015 10.2 µM -2.21438461179338 0.00857963297164027 no 3293 0.0134011662757849 4674 4227577
SGTC_1617 st002906 78 µM -2.22311353474899 0.0083649561234793 no 3294 0.013104072609388 4721 5150859
SGTC_1549 4'-methoxyflavonol 74.6 µM -2.23241800528373 0.00814133101205092 no 3295 0.0127936744479352 4754 97141
SGTC_1502 4534-4282 27.7 µM -2.23435256522567 0.00809550074800594 no 3296 0.0127299420948162 4743 3278949
SGTC_2168 5727979 200 µM -2.23980503213111 0.00796754819819885 no 3297 0.0125517915268861 4682 695210
SGTC_991 3996-0057 64.7 µM -2.24163696916638 0.00792495918254475 no 3298 0.0124924223073214 4727 715343
SGTC_2645 abamectin 100 µM -2.2490117981936 0.00775552719981297 no 3299 0.0122558727265876 4718 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2383 9036125 200 µM -2.25108110615353 0.00770856253440089 no 3300 0.0121902004291173 4714 79580
SGTC_2908 7930301 100 µM -2.26990690161599 0.00729266489612417 no 3301 0.0116066161422373 4693 2223178
SGTC_2855 9016525 58.44 µM -2.27652361028468 0.00715125962033777 no 3302 0.0114073445629183 4695 43811474
SGTC_2016 5121758 140 µM -2.28343167320909 0.00700621400308291 no 3303 0.0112024766714956 4675 2795203
SGTC_2344 7990960 76.95 µM -2.29604885984442 0.00674798709082419 no 3304 0.0108365439307827 4705 140813
SGTC_1515 3460-0031 42.1 µM -2.31020133041972 0.00646837755401336 no 3305 0.010438505216215 4730 2876596
SGTC_1197 1601-0112 267 µM -2.31045652082505 0.00646343127309518 no 3306 0.0104314465115434 4727 7350313
SGTC_119 0121-0043 24.815 µM -2.35712394462665 0.00561325530507642 no 3307 0.00920854928767304 4737 1092378
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -2.35789870868756 0.0056000212778133 no 3308 0.00918935351083272 4740 688761
SGTC_1387 3342-1166 1.8 µM -2.37558399906977 0.00530537355203005 no 3309 0.00876060195178986 4760 3418228
SGTC_26 0302-0163 425.158 µM -2.39067242755418 0.00506497657210541 no 3310 0.00840877507898547 4777 3100915
SGTC_2791 5663188 71.43 µM -2.4025187669105 0.00488308231807556 no 3311 0.00814129952916341 4731 54690634
SGTC_2019 4016004 108 µM -2.41408310461113 0.00471115675218614 no 3312 0.00788743194227569 4733 45595336
SGTC_1443 4112-3303 14 µM -2.4166385197602 0.00467390207194505 no 3313 0.00783228237882791 4772 704433
SGTC_2865 9030313 51.95 µM -2.43039623767056 0.00447781298994034 no 3314 0.00754116198504825 4745 42562754
SGTC_387 norethindrone acetate 66.7 µM -2.44201290402691 0.00431799699787617 no 3315 0.00730281227605799 4760 541197
SGTC_1848 st056003 16.4 µM -2.44274571234914 0.00430808850632576 no 3316 0.00728800176099976 4743 146492
SGTC_580 1123-0028 41 µM -2.4610598239376 0.00406696950582117 no 3317 0.00692636326583965 4773 1677248 YPR107C YTH1
SGTC_917 harmaline 728.087 nM -2.5152009559253 0.00342321711719466 no 3318 0.00594822765705304 4708 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_915 methyl methanesulfonate (MMS) 110 mM -2.51892503033127 0.00338250091442659 no 3319 0.00588568585833656 4756 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2264 7948757 110.76 µM -2.5473123490141 0.00308616695264489 no 3320 0.00542781096976444 4738 2971411
SGTC_1477 0139-0234 16 µM -2.54750154683839 0.0030842729253015 no 3321 0.00542486860513772 4768 620880
SGTC_2885 9057732 51.95 µM -2.57502533688793 0.00281963594739001 no 3322 0.00501163719553084 4769 6471414
SGTC_3043 9092303 49.47 µM -2.58669711465287 0.00271373548666582 no 3323 0.00484503643154413 4764 25236084
SGTC_2580 diallyl disulphide 81.36 µM -2.60069891420725 0.00259143980262734 no 3324 0.00465170331462455 4741 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1731 st035964 63 µM -2.63668362437576 0.0022996559337723 no 3325 0.00418604371647976 4712 6739575
SGTC_3329 9141233 27.5565 µM -2.66376376867206 0.00210006197659387 no 3326 0.00386359027938269 4747 4909101 YNL103W MET4
SGTC_2785 7756463 72.73 µM -2.68469804707156 0.00195668278659014 no 3327 0.00362976795623291 4756 2201551
SGTC_2481 5478948 45.16 µM -2.72798804360263 0.00168801140391734 no 3328 0.00318609588243565 4770 77792
SGTC_2091 4-phenylthiadiazole 200 µM -2.73602117986252 0.00164201760003732 no 3329 0.00310935116576149 4781 270010
SGTC_380 3970-0968 6 µM -2.7540894902113 0.00154271062788236 no 3330 0.00294278363145442 4762 2891601
SGTC_2266 7929956 200 µM -2.81932774925105 0.00122803994312334 no 3331 0.00240621761163559 4766 2967153
SGTC_860 0443-0016 25.1 µM -2.82056955377197 0.00122266560869529 no 3332 0.00239692399692164 4788 5337942
SGTC_2630 antimycin a 100 µM -2.87445412507817 0.00100918535467157 no 3333 0.00202363280523668 4754 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1724 st037281 8.293 µM -2.89638588667188 0.000932542778422969 yes 3334 0.0018874395136119 4761 574124 YDL195W SEC31
SGTC_78 0336-0123 156.75 µM -2.92177569745219 0.000850513112561926 yes 3335 0.0017402104548461 4753 6765896
SGTC_3188 9110789 49.47 µM -2.94384163606497 0.000784669120661919 yes 3336 0.00162082912837892 4782 849217
SGTC_1723 st034307 2.5525 µM -2.96551215012859 0.000724603347399102 yes 3337 0.00151089704404728 4775 867466
SGTC_2940 9060638 45.86 µM -3.01259446053645 0.000608427031236838 yes 3338 0.0012951240426738 4767 4027022
SGTC_855 0428-0020 25 µM -3.02534797956079 0.000580062226746657 yes 3339 0.00124173607705246 4795 6812414
SGTC_2934 9036370 36.88 µM -3.0395091547522 0.000550001578922585 yes 3340 0.00118482000309475 4775 6462800
SGTC_851 0394-0702 453 µM -3.05028641973003 0.000528096733254608 yes 3341 0.00114311611648862 4785 762646
SGTC_3154 9100113 49.47 µM -3.08545251990111 0.000462110433680315 yes 3342 0.0010162133555268 4782 25237525
SGTC_783 0848-0141 92.7 µM -3.08983496503553 0.000454445254396798 yes 3343 0.00100133870506249 4778 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1391 3442-0225 151 µM -3.1121142082116 0.000417267328395236 yes 3344 0.000928763111909286 4796 5227075
SGTC_787 4152-0075 138 µM -3.12333618730674 0.000399628542107105 yes 3345 0.000894066863300308 4786 9566539
SGTC_845 0330-0138 4.51 µM -3.1290445935571 0.000390923952197304 yes 3346 0.000876878452811923 4787 9039800
SGTC_2864 9034755 47.6 µM -3.29389860405098 0.000203866246144543 yes 3347 0.000494040673166584 4791 4930451
SGTC_2340 7987427 183.45 µM -3.36419895367842 0.000153079501129174 yes 3348 0.000383830913116937 4792 2239331
SGTC_2349 9023730 187.07 µM -3.40413302445232 0.000129779768367845 yes 3349 0.000331872103725041 4796 4126287
SGTC_856 0433-0016 11.3 µM -3.40954172970366 0.00012689285334081 yes 3350 0.000325360609506989 4805 3911780
SGTC_3317 9138495 8.753 µM -3.46392725215089 0.000101027243125998 yes 3351 0.000266175228556303 4802 17020139
SGTC_1462 k081-0014 26.5 µM -3.50155051562605 8.61274248341181e-05 yes 3352 0.000231279636314528 4488 3270634
SGTC_792 4534-1957 155 µM -3.57678154393357 6.23138322728659e-05 yes 3353 0.000173925318201572 4800 1717904
SGTC_3321 9137793 26.8275 µM -3.64273963507417 4.66836882042831e-05 yes 3354 0.000134875827138903 4805 4904192
SGTC_2662 daunorubicin 22.37 µM -3.7358018652239 3.08124102752425e-05 yes 3355 9.3558980860304e-05 4729 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_818 4072-2707 53.5 µM -3.82906847678573 2.012770938245e-05 yes 3356 6.43146077817124e-05 4798 882871