SGTCid condition conc unit RSC58|YLR033W.score RSC58|YLR033W.strain.pval RSC58|YLR033W.strain.significant RSC58|YLR033W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_3304 9125678 46.087 µM 24.0405784901133 5.72205123212562e-44 yes 1 5.2371648537951e-128 5 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2912 7964298 10.93 µM 23.6872533047855 9.5325147053588e-43 yes 2 2.43980222671e-124 1 2975850 SGTC_1652 st011932 78 µM 23.682194479502 9.92131013819595e-43 yes 3 2.75095107367313e-124 1 1551076 SGTC_2186 6124449 200 µM 23.3642289086892 1.20351225241163e-41 yes 4 4.93934005883781e-121 1 3834182 YLR033W RSC58 SGTC_177 1327-0068 8.361 µM 23.0825830820313 1.0676620566855e-40 yes 5 3.46369204661765e-118 2 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_643 k048-0106 28.4 µM 22.6979159492614 2.01755264705191e-39 yes 6 2.34870251655353e-114 1 6763920 SGTC_2534 helenine 20.12 µM 22.4610042171687 1.20336640985885e-38 yes 7 4.9952304888922e-112 1 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2225 6654152 15.4 µM 21.5444282113058 1.01231799313712e-35 yes 8 2.98581398537649e-103 2 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2233 sulbentine 40.3845 µM 21.0407604840697 3.64263690396763e-34 yes 9 1.38942777982098e-98 2 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_64 000l-0018 272.079 µM 19.3175804563593 4.08227007064882e-29 yes 10 1.91073736731909e-83 4 6811119 SGTC_2109 5483026 200 µM 19.1898783591024 9.29440498021874e-29 yes 11 2.24845442869975e-82 2 759335 SGTC_2348 9022543 33.42 µM 18.3957148822717 1.37426436467958e-26 yes 12 7.10866331625176e-76 2 3162678 YDL140C RPO21 SGTC_1133 3473-0247 50 µM 18.2079746514687 4.34373026090528e-26 yes 13 2.23074213745109e-74 1 711311 SGTC_709 3807-1509 243 µM 18.1899837119007 4.84722603607586e-26 yes 14 3.09792876887304e-74 1 1886677 YPL242C IQG1 SGTC_783 0848-0141 92.7 µM 18.1299363160012 6.98445290762134e-26 yes 15 9.24866194841575e-74 1 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2111 5486399 200 µM 17.6027200615473 1.6401897647344e-24 yes 16 1.17386413578259e-69 2 689674 SGTC_673 1082-0474 110 µM 17.5953340712492 1.71323129642187e-24 yes 17 1.33736899151729e-69 1 3098046 SGTC_445 e6 berbamine 66 µM 16.5710327207066 6.0616961579856e-22 yes 18 5.64352722460128e-62 3 6610268 A calcium/calmodulin antagonist. SGTC_1722 st034304 3.6505 µM 16.021698878877 1.22436444674806e-20 yes 19 4.50765448861396e-58 1 4036148 YLR033W RSC58 SGTC_970 1315-0089 19.5 µM 15.7451014568404 5.35661191910544e-20 yes 20 3.71059994249713e-56 1 6811083 YLR033W RSC58 SGTC_2336 9001819 198.65 µM 15.4419381939043 2.62376101992126e-19 yes 21 4.27460295727595e-54 5 2989602 SGTC_268 camptothecin 39.6153 µM 15.3036260220569 5.36283511880494e-19 yes 22 3.61565019058623e-53 2 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_525 k781-2675 26.7 µM 15.1211298674491 1.36420857422834e-18 yes 23 5.87544774059731e-52 3 3651118 YDL195W SEC31 SGTC_1374 2889-5571 141 µM 15.1201013009414 1.37136390015963e-18 yes 24 5.96794274227226e-52 4 2853281 SGTC_2344 7990960 76.95 µM 14.9919397539322 2.62460391468469e-18 yes 25 4.14481817290041e-51 2 140813 SGTC_3120 9124077 49.47 µM 14.6245418729152 1.63783650732901e-17 yes 26 9.79424836900439e-49 4 18774327 YGL155W CDC43 SGTC_257 daunorubicin 18.5 µM 14.2334378967114 1.09574978845498e-16 yes 27 2.84092017784857e-46 2 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2378 9074213 121.43 µM 13.8018991912123 8.41951617222298e-16 yes 28 1.24112873987652e-43 1 657714 SGTC_871 0574-0004 149 µM 13.3862240917017 5.66663255749134e-15 yes 29 3.6394100587983e-41 1 9551173 SGTC_157 1348-1695 65.819 µM 12.752850826199 9.28827884837853e-14 yes 30 1.50274886617294e-37 3 5380510 SGTC_825 1988-2224 89.6 µM 12.5903816670691 1.8635648885211e-13 yes 31 1.19258649571595e-36 1 1180859 SGTC_2229 7354935 190 µM 12.3112627155402 6.0416853987059e-13 yes 32 3.93904414680115e-35 1 318112 SGTC_566 0958-0068 16.5 µM 11.9505474189566 2.66062623507464e-12 yes 33 3.22494902028851e-33 1 6815365 SGTC_1884 5633444 25 µM 11.6698525729166 8.18967898259792e-12 yes 34 9.08689548126802e-32 1 5724239 SGTC_203 k066-0004 30.888 µM 11.5908595532925 1.11859703196508e-11 yes 35 2.29253974342426e-31 1 6795412 SGTC_2129 girgensonine 121.053 µM 11.2683543780393 3.9117029938645e-11 yes 36 9.40258450186764e-30 3 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1239 0337-0584 35.4 µM 11.1849116678333 5.37834692613242e-11 yes 37 2.41693273470345e-29 4 914301 YML130C ERO1 SGTC_1679 SEC14.276 6.7 µM 11.0702679063773 8.29924588621145e-11 yes 38 8.74385090503368e-29 5 1005053 YMR079W SEC14 SGTC_2766 oltipraz 83.91 µM 10.9862637161085 1.13737626541448e-10 yes 39 2.22483543390035e-28 2 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2400 5203494 178.7 µM 10.8968351935119 1.58677472659954e-10 yes 40 5.96680568738834e-28 1 6777674 SGTC_916 4466-0038 42 nM 10.8044901810193 2.23182905161761e-10 yes 41 1.63886349879295e-27 7 5722064 YGL116W CDC20 SGTC_829 1635-0120 117 µM 10.737260087264 2.85601640595843e-10 yes 42 3.40167710070392e-27 5 285054 SGTC_2471 5466956 24.79 µM 10.7070910414274 3.18870437813571e-10 yes 43 4.71388845432904e-27 4 724419 SGTC_928 2764-0428 58.7 µM 10.6663018960123 3.69921542821988e-10 yes 44 7.31675619653145e-27 3 662578 SGTC_329 k048-0121 21.3 µM 10.4467526010116 8.15153903274727e-10 yes 45 7.58142176861358e-26 1 6832902 SGTC_272 doxorubicin 8.13 µM 10.3082201035079 1.33126202958989e-09 yes 46 3.23441195442862e-25 2 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1870 st057514 26.5 µM 10.3048899067528 1.34694934563869e-09 yes 47 3.34841563867111e-25 2 5393161 SGTC_324 1315-0088 19.6 µM 10.2074674510897 1.89452118952327e-09 yes 48 9.1797116658183e-25 1 6787421 SGTC_1723 st034307 2.5525 µM 10.1276371584293 2.49978279268363e-09 yes 49 2.08297228765762e-24 1 867466 SGTC_288 1315-0019 35.1 µM 9.97457902235387 4.22910665264324e-09 yes 50 9.84673991679397e-24 3 6811474 SGTC_1844 rapamycin 4 nM 9.64545495737869 1.27685127493241e-08 yes 51 2.56914190921633e-22 11 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_586 0957-0265 8.15 µM 9.40891269203494 2.76483628503464e-08 yes 52 2.50647807671799e-21 7 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1731 st035964 63 µM 9.2124969823094 5.18003165795837e-08 yes 53 1.5931254876712e-20 2 6739575 SGTC_3037 9091026 49.47 µM 9.16304916563262 6.05516516987231e-08 yes 54 2.52256059171797e-20 8 25236398 YIL048W NEO1 SGTC_2475 5812728 15.03 µM 9.10671518270287 7.22677290602417e-08 yes 55 4.24569725607527e-20 5 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1098 clofazimine 15.1 µM 9.05679466848199 8.44591899279528e-08 yes 56 6.71700840660349e-20 5 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 8.96686532551303 1.11617390012464e-07 yes 57 1.52536386863834e-19 1 279621 SGTC_1567 st069303 68.4 µM 8.92401502506854 1.27359250001432e-07 yes 58 2.24841407591318e-19 1 5581319 SGTC_1875 nocodazole 6 µM 8.87814439099108 1.46583139735649e-07 yes 59 3.39924757971546e-19 10 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2679 rapamycin 1 nM 8.78392186077365 1.95242040354621e-07 yes 60 7.89356913740054e-19 13 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_331 k048-0133 24.5 µM 8.73542532938085 2.26029895778339e-07 yes 61 1.21370507978572e-18 1 6813582 SGTC_1707 st032323 6.317 µM 8.57291413461074 3.67176891789454e-07 yes 62 5.04493673569999e-18 10 3132057 YMR211W DML1 SGTC_1493 4348-0038 111 µM 8.53556706524928 4.09995779845773e-07 yes 63 6.9734839122688e-18 6 800424 SGTC_2799 7812892 81.82 µM 8.52874764184806 4.18317000277975e-07 yes 64 7.39702588920332e-18 3 20205235 SGTC_58 0957-0393 9 µM 8.40880171115765 5.94197291867641e-07 yes 65 2.07110350302616e-17 12 6997992 SGTC_1446 4239-0190 62 µM 8.31759122042974 7.73571450687639e-07 yes 66 4.48845001384037e-17 1 1340085 SGTC_322 k048-0136 19.3 µM 8.30171695132756 8.09696081722544e-07 yes 67 5.13087267203706e-17 1 6823282 SGTC_2408 sulbentine 18.36 µM 8.29145731258578 8.33900509118396e-07 yes 68 5.59346406528066e-17 9 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_227 fluconazole 33.516 µM 8.25041433696098 9.37869295892239e-07 yes 69 7.89231451278981e-17 19 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_138 0850-0259 40.9225 µM 8.23095087078189 9.91423386771466e-07 yes 70 9.28665695192914e-17 18 6813004 SGTC_248 streptozotocin 5.23457 mM 8.1481094359689 1.25405975538016e-06 yes 71 1.84828878996421e-16 4 5300 DNA alkylating agent. SGTC_2619 obliquin 87.91 µM 8.13824727104925 1.28945082390471e-06 yes 72 2.00520570815391e-16 6 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3288 9119690 36.221 µM 8.13347774946302 1.30690860726111e-06 yes 73 2.08573341879534e-16 7 17595618 YKL019W RAM2 SGTC_2041 5107442 45.335 µM 8.08551011151154 1.4955731809988e-06 yes 74 3.09522708969854e-16 9 793005 SGTC_2930 9013230 14.89 µM 8.07304383422744 1.5487280759684e-06 yes 75 3.42834885889487e-16 7 2995857 SGTC_2396 5342950 42.78 µM 8.04092887031304 1.69414122878608e-06 yes 76 4.45800020248532e-16 8 1886677 SGTC_2510 benzyl isothiocyanate 8.31 µM 8.03602863289483 1.71744928367794e-06 yes 77 4.63985343377738e-16 4 2346 DNA damaging agent; causes G2/M arrest. SGTC_2361 9034121 116 µM 7.9618180745604 2.11031763842279e-06 yes 78 8.4764806203636e-16 7 6496917 SGTC_951 1171-0579 82.7 µM 7.94338406592049 2.22050853895971e-06 yes 79 9.83692877462525e-16 4 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2582 agaric acid 100 µM 7.91890964381731 2.37534943793477e-06 yes 80 1.19801190520524e-15 10 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2066 5222451 176 µM 7.90867080935468 2.44314961335481e-06 yes 81 1.30075760050362e-15 7 2281147 SGTC_666 0272-0154 136 µM 7.82987980074562 3.03054468529887e-06 yes 82 2.44168306713395e-15 1 6870312 SGTC_1044 1222-0021 1.78 µM 7.8013660995972 3.27469758638538e-06 yes 83 3.06202822961882e-15 6 4306703 SGTC_1396 3511-0007 98.6 µM 7.72411825012036 4.03431842947032e-06 yes 84 5.63151242922221e-15 1 X1396 SGTC_1311 1190-0148 100 µM 7.70853597636908 4.20673895694518e-06 yes 85 6.36346224930187e-15 2 1961333 SGTC_351 caspofungin 25 nM 7.69777667903593 4.32987906688738e-06 yes 86 6.92270340257452e-15 7 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1371 2421-0008 32.7 µM 7.62337270364258 5.28065896525607e-06 yes 87 1.23566000519009e-14 2 2827552 SGTC_885 0865-0106 16.8 µM 7.61292804963243 5.42911655472235e-06 yes 88 1.33977486366105e-14 2 2793380 SGTC_273 hydroxyurea 18.1 mM 7.61142472154409 5.45080976737435e-06 yes 89 1.35545390453522e-14 3 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2671 danthron 100 µM 7.60559040528205 5.53578611051803e-06 yes 90 1.4180308459644e-14 3 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_342 k048-0088 23.3 µM 7.58274129494783 5.88091656801066e-06 yes 91 1.69164527708856e-14 1 6820570 SGTC_788 1182-0090 188 µM 7.56442983800348 6.17223584682983e-06 yes 92 1.94784768775338e-14 4 5715185 SGTC_3266 9136860 49.47 µM 7.56360879587645 6.18561528212289e-06 yes 93 1.96018809938134e-14 3 4871271 YPR165W RHO1 SGTC_3277 9138724 49.47 µM 7.40059683870653 9.46777015231927e-06 yes 94 6.7786879583997e-14 4 15943418 SGTC_1274 0865-0114 173 µM 7.37576341686188 1.00945838131933e-05 yes 95 8.17029828159342e-14 1 870624 SGTC_319 1348-1596 45.5 µM 7.2947760534236 1.24248891979232e-05 yes 96 1.49578126691802e-13 1 5380505 SGTC_2132 5317594 122.667 µM 7.29150837970511 1.25289046703863e-05 yes 97 1.53251911587079e-13 1 794577 SGTC_632 0781-2353 4.65 µM 7.26944689956082 1.3253138015692e-05 yes 98 1.80481188629362e-13 2 6811515 YHR007C ERG11 SGTC_2575 plumbagin 510 nM 7.2613831254958 1.35276568447795e-05 yes 99 1.91575993028622e-13 6 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1651 st011928 86.1 µM 7.21108377876578 1.53659698808326e-05 yes 100 2.77541438665683e-13 5 720198 SGTC_354 2783-3500 4.88 µM 7.19349093118768 1.60632245204173e-05 yes 101 3.15776747853687e-13 8 6740761 SGTC_1831 st055328 12 µM 7.18026814261954 1.66069582384892e-05 yes 102 3.47874132761634e-13 5 1103068 SGTC_3154 9100113 49.47 µM 7.14829181758149 1.79950276078741e-05 yes 103 4.39321869739357e-13 1 25237525 SGTC_2346 9031566 143.75 µM 7.06269292536995 2.22733313226201e-05 yes 104 8.1653173363819e-13 4 4771086 SGTC_2962 9082311 13.18 µM 7.05210014838667 2.28653750948943e-05 yes 105 8.81186392788326e-13 3 16459453 SGTC_2756 carbadox 75.1 µM 7.04614172179955 2.3204926129254e-05 yes 106 9.19734541665536e-13 8 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2974 9094440 9.66 µM 6.99758217315495 2.61560232125521e-05 yes 107 1.30208665510932e-12 6 25236134 SGTC_1090 efavirenz 20.7 µM 6.95218026887528 2.92340800306896e-05 yes 108 1.79841681692559e-12 1 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2187 6125751 200 µM 6.87897147705097 3.49304220152471e-05 yes 109 3.01431141883476e-12 1 874498 SGTC_2971 9092186 9.93 µM 6.87237960401904 3.54919035325045e-05 yes 110 3.15698320998185e-12 3 25236400 SGTC_3321 9137793 26.8275 µM 6.83274992119945 3.9051601190449e-05 yes 111 4.16510514058661e-12 6 4904192 SGTC_2759 disulfiram 3.38 µM 6.75552177630584 4.69798634807896e-05 yes 112 7.11610644068851e-12 5 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2269 7935389 174.42 µM 6.7069464012287 5.27209952083277e-05 yes 113 9.93696089443707e-12 1 97605 SGTC_2387 9077560 195.08 µM 6.689066126051 5.49962857874662e-05 yes 114 1.12299617161888e-11 3 5303272 SGTC_2071 5230951 39.92 µM 6.61154886741653 6.5975085677467e-05 yes 115 1.9015976370683e-11 2 1799272 SGTC_2617 dihydrotanshinone i 20.83 µM 6.59652526602165 6.83289691754246e-05 yes 116 2.1045290008711e-11 7 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_576 1073-0113 22.7 µM 6.58593564231526 7.00354365965227e-05 yes 117 2.26014804224634e-11 15 5439563 SGTC_181 1447-1644 8.07 µM 6.58062399642118 7.09064237922636e-05 yes 118 2.3423897379549e-11 5 534600 SGTC_642 0335-0876 158 µM 6.575368692208 7.17782045699376e-05 yes 119 2.42663784256776e-11 4 6812350 SGTC_1453 4237-0541 195 µM 6.51878067050214 8.18272950900794e-05 yes 120 3.5440603593459e-11 7 739892 SGTC_590 k048-0076 22.4 µM 6.5184686969686 8.18861979321151e-05 yes 121 3.55143780049783e-11 3 6832814 SGTC_1171 0368-0077 21.4 µM 6.4834846566757 8.87504876890886e-05 yes 122 4.48139983377071e-11 1 3239779 SGTC_145 3737-0113 38.366 µM 6.45789983672463 9.41092272626746e-05 yes 123 5.3082983960733e-11 14 6849351 SGTC_2277 7947813 106.88 µM 6.3456248268861 0.000121425465944318 yes 124 1.10762245884642e-10 6 1246798 SGTC_69 0096-0274 206.684 µM 6.26924554583133 0.000144085436371638 yes 125 1.81400816757983e-10 21 6741392 SGTC_1026 k007-1105 30.6 µM 6.26585467035794 0.000145177958673579 yes 126 1.85393013355567e-10 15 7066794 SGTC_520 3584-0023 682 µM 6.20134096666909 0.000167501277219097 yes 127 2.7992037159309e-10 5 1340790 SGTC_1168 k815-0004 80.5 µM 6.199045464089 0.000168351863051415 yes 128 2.84033111206598e-10 5 642433 SGTC_2380 9035439 200 µM 6.19162738355035 0.000171128304992439 yes 129 2.97730930535522e-10 2 6462575 SGTC_93 0109-0045 59.227 µM 6.16894273457501 0.000179886822098784 yes 130 3.43740592699781e-10 2 88733 SGTC_103 0844-0104 51.839 µM 6.15605354154132 0.000185048305146531 yes 131 3.72900093983438e-10 22 5375804 SGTC_746 1095-0025 46.6 µM 6.14857619877733 0.000188105734617119 yes 132 3.909078310591e-10 3 6749286 SGTC_1229 0139-0193 12.2 µM 6.12559454236952 0.000197800944901182 yes 133 4.51728028129751e-10 7 3090752 SGTC_1773 st048542 73.5835 µM 5.97565950561521 0.000273441921720847 yes 134 1.14580596735267e-09 12 3237138 SGTC_984 1492-0255 2.91 µM 5.94391532537373 0.00029258317208451 yes 135 1.39146697284488e-09 4 1585198 SGTC_3247 9135149 49.47 µM 5.92209014082629 0.000306459259526583 yes 136 1.58937646783241e-09 10 8934436 YOR116C RPO31 SGTC_557 1315-0110 16.2 µM 5.88520198764279 0.000331312540716451 yes 137 1.98784073803704e-09 2 6833801 SGTC_839 0122-0028 230 µM 5.88259652335641 0.000333136983607878 yes 138 2.01939827585743e-09 14 759448 SGTC_262 fenpropimorph 62.5 µM 5.86840250674887 0.000343241298504938 yes 139 2.2000700384506e-09 8 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2199 6590217 200 µM 5.84486482162828 0.000360627152008116 yes 140 2.5348989516963e-09 1 703109 SGTC_2092 5303694 80.6725 µM 5.83441780059171 0.000368602905845984 yes 141 2.69893551921961e-09 1 1963699 SGTC_818 4072-2707 53.5 µM 5.75427124072855 0.000435463204181919 yes 142 4.35081738101516e-09 1 882871 SGTC_1800 st050079 29.0735 µM 5.74383431826123 0.000444953617325631 yes 143 4.62781768331947e-09 9 3645560 SGTC_964 1287-0107 19.4 µM 5.72879694569715 0.000458964758196498 yes 144 5.05726882504366e-09 7 51516812 YPR165W RHO1 SGTC_580 1123-0028 41 µM 5.68091631403819 0.000506347432513699 yes 145 6.69875110694583e-09 9 1677248 YPR107C YTH1 SGTC_1868 st057644 42.7 µM 5.66912982363373 0.000518686294991576 yes 146 7.17622930792859e-09 2 688665 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 5.6678182777402 0.000520076375724561 yes 147 7.23136167766825e-09 2 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_22 0964-0034 14.468 µM 5.58943115650752 0.000609699785374615 yes 148 1.13907330665853e-08 19 138402 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 5.55451400615528 0.000654043786487367 yes 149 1.39192596481807e-08 3 94937 An inhibitor of serotonin biosynthesis. SGTC_2928 9011484 9.79 µM 5.51609628434193 0.00070626006161819 yes 150 1.73306205248547e-08 16 2994751 SGTC_1898 st060199 18.6 µM 5.50091396186868 0.000727934931391075 yes 151 1.88913779626395e-08 1 688866 SGTC_2485 5633444 17.78 µM 5.49674423294017 0.000733994199457745 yes 152 1.93433583515761e-08 4 5724239 SGTC_67 0335-0847 266 µM 5.43609786574316 0.000827540316406635 yes 153 2.7230025150009e-08 10 4552207 YOR254C SEC63 SGTC_1672 st016598 6.51 µM 5.36591813638997 0.000949419009879799 yes 154 4.02692334334258e-08 8 4665860 YNL267W PIK1 SGTC_1696 st025591 34.7925 µM 5.3640321529006 0.000952910934643932 yes 155 4.06922036217797e-08 2 2787147 SGTC_2567 aureobasidin a 60 nM 5.36251656218237 0.000955725615537534 yes 156 4.10352203855474e-08 23 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_794 k038-0031 316 µM 5.35270795316881 0.000974127060552467 yes 157 4.33238174582978e-08 8 6624242 SGTC_995 3931-2021 34.6 µM 5.33629599621904 0.0010056456264277 no 158 4.74322468893391e-08 2 730143 SGTC_462 ag-879 158 µM 5.31012506570007 0.00105784698689546 no 159 5.47750165356612e-08 4 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_56 0957-0365 83.25 µM 5.29203063042861 0.00109537927593083 no 160 6.04828126597392e-08 4 6752360 SGTC_200 k038-0079 37.545 µM 5.29076014615842 0.001098059892027 no 161 6.09045128807445e-08 5 3436683 SGTC_1754 st042065 16.137 µM 5.28177907425252 0.00111718134944601 no 162 6.39677082946936e-08 15 1126236 YIL048W NEO1 SGTC_2973 9094665 17.96 µM 5.27835302228109 0.0011245557506033 no 163 6.51750789742265e-08 8 25237061 YIL048W NEO1 SGTC_3110 9122132 49.47 µM 5.26375345065841 0.00115648322685888 no 164 7.05718507742931e-08 1 918317 SGTC_1195 1502-0147 41.1 µM 5.238717305013 0.00121317275906343 no 165 8.08482516394758e-08 1 817940 SGTC_1174 0739-0097 51.1 µM 5.21387323605236 0.00127193088808099 no 166 9.24689352236519e-08 2 728447 SGTC_311 1315-0136 58 µM 5.21116046241941 0.00127850198592371 no 167 9.38315230291439e-08 2 6759207 SGTC_165 k038-0023 64.381 µM 5.19323329003426 0.00132271292471481 no 168 1.03336470072521e-07 14 46368543 SGTC_1525 8-methoxypsoralen 92.5 µM 5.17447791098194 0.00137045831712706 no 169 1.14274572693332e-07 6 4114 Related to psoralen; DNA damaging agent. SGTC_1279 0874-0590 65.2 µM 5.14562337403255 0.00144699389115156 no 170 1.33316947505171e-07 1 3523074 SGTC_1803 st050068 52.4 µM 5.04751772720871 0.00173731070796097 no 171 2.23793626243118e-07 11 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2654 protoveratrine a 100 µM 5.04671606664911 0.00173988722739029 no 172 2.24734269042175e-07 1 5702278 A heart drug and vasodilator. SGTC_2105 5350118 200 µM 5.02977529366735 0.00179515412948391 no 173 2.45527492453325e-07 2 2133313 SGTC_572 0960-0087 17.7 µM 5.02695156850688 0.00180451987983551 no 174 2.49169072576516e-07 4 6796365 SGTC_2698 st077697 67.5 µM 4.99704027285879 0.00190649408019737 no 175 2.91084569788946e-07 2 3154499 SGTC_969 1313-0238 134 µM 4.9906356150305 0.00192899833315314 no 176 3.00904654462245e-07 11 5212874 SGTC_185 k048-0037 25.491 µM 4.94383089443568 0.00210092204884605 no 177 3.8301078481219e-07 2 6827589 SGTC_1113 artemisinin 1.17947 µM 4.93735024849592 0.00212579227244168 no 178 3.95955862048436e-07 21 2240 An anti-malaria and mitochondrial poison. SGTC_212 3807-4682 38.772 µM 4.87889296184762 0.0023624893736867 no 179 5.33414688316819e-07 18 3125501 YBL034C STU1 SGTC_2845 9003024 42.97 µM 4.8588044458292 0.00244917993221441 no 180 5.90483526806505e-07 5 2990173 SGTC_558 k064-0027 21.3 µM 4.84415668595621 0.00251419436788199 no 181 6.35752825265748e-07 6 5088526 SGTC_1991 st073000 8.92 µM 4.84074452562327 0.00252956165395619 no 182 6.46767898182209e-07 11 4301969 YIL048W NEO1 SGTC_1772 st048439 82.2 µM 4.82552923537063 0.00259912515147651 no 183 6.98159897135145e-07 6 2927068 YDL195W SEC31 SGTC_3198 9112019 49.47 µM 4.82441505279713 0.0026042864305757 no 184 7.02073725826054e-07 3 45595555 SGTC_1162 k048-0130 20.1 µM 4.81862651964468 0.00263125024475531 no 185 7.22749251295204e-07 6 6797406 SGTC_2107 5363541 170.161 µM 4.80720064009598 0.00268521501881641 no 186 7.65291809317221e-07 3 244052 SGTC_1050 3232-1156 69.3 µM 4.79606957990245 0.00273874636284836 no 187 8.09045476731459e-07 16 700529 SGTC_2029 5175081 200 µM 4.78469069941968 0.00279446338878811 no 188 8.56254192659039e-07 3 1380876 SGTC_160 3453-0671 289.699 µM 4.77619665671173 0.00283671917923553 no 189 8.93208488344367e-07 3 5322268 SGTC_3099 9120367 49.47 µM 4.76157157418933 0.00291082773189548 no 190 9.60455727826058e-07 1 24824940 SGTC_1547 harmine 94.2 µM 4.74968680893686 0.00297233109019703 no 191 1.01865961153558e-06 9 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2519 cryptotanshinone 88.04 µM 4.72568520407078 0.00310012187811044 no 192 1.1467034983526e-06 13 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2194 5927483 104.545 µM 4.72208116518045 0.00311973212823387 no 193 1.1672173945601e-06 3 760979 SGTC_863 0466-0191 129 µM 4.72064250388975 0.00312759129017774 no 194 1.17550414657275e-06 17 765160 YPR165W RHO1 SGTC_459 nigericin 15.3 µM 4.70998557991782 0.00318636545058289 no 195 1.23867159212057e-06 6 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1992 st073643 23.3 µM 4.67184411841625 0.00340495134228819 no 196 1.49253736452406e-06 5 3161292 SGTC_2747 doxorubicin 7.63 µM 4.63496696109236 0.00362900863687317 no 197 1.78497246588684e-06 4 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2544 sphondin 68.51 µM 4.62354605748401 0.00370103468856363 no 198 1.88617466307333e-06 28 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_330 1488-0319 80.1 µM 4.62016325930818 0.00372261311447616 no 199 1.91719102040644e-06 5 6846614 SGTC_574 1315-0397 40 µM 4.60337925313412 0.00383135379439422 no 200 2.07845123062005e-06 5 6794277 SGTC_1896 st058441 89 µM 4.60017347826887 0.00385244437818549 no 201 2.11069618679163e-06 4 688759 SGTC_352 k048-0007 5.11 µM 4.59918169849671 0.0038589902739381 no 202 2.12076861380708e-06 9 6811911 SGTC_2626 ethyl orsellinate 100 µM 4.57509987726286 0.00402102397854468 no 203 2.37996426841749e-06 5 75653 A natural product. SGTC_304 1310-0298 97 µM 4.57385466825084 0.00402956558865646 no 204 2.39416020190625e-06 3 1550234 SGTC_1897 st060201 15 µM 4.56897182559276 0.00406321679156684 no 205 2.45061327998973e-06 4 611878 SGTC_2997 9067075 71.4286 µM 4.56609004105658 0.00408319508839536 no 206 2.48452698523186e-06 15 27209819 SGTC_2124 5246320 200 µM 4.53834225359879 0.00428010519555173 no 207 2.8349092764497e-06 25 579342 SGTC_2705 st078069 42.8 µM 4.52237984612406 0.00439718890394787 no 208 3.05740994308036e-06 2 1530061 SGTC_158 k038-0087 26.446 µM 4.51709334487288 0.00443659130052805 no 209 3.13471364458269e-06 26 X158 SGTC_1693 xanthone 101.9 µM 4.49916671870216 0.00457256425406936 no 210 3.41101707843653e-06 5 7020 An insecticide. SGTC_430 0958-0115 16.4 µM 4.47386415224824 0.00477081340512665 no 211 3.84092785386094e-06 6 6833180 SGTC_1165 k072-0275 30.3 µM 4.47136461575699 0.00479080766571469 no 212 3.88610279660899e-06 7 6153523 YGL055W OLE1 SGTC_2188 6126565 140.678 µM 4.43904758648536 0.00505612786683282 no 213 4.51789193074687e-06 4 874518 SGTC_2533 agelasine 13.65 µM 4.43440735449884 0.00509527915304202 no 214 4.61629557377557e-06 8 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1300 1094-0077 113 µM 4.42853048180246 0.00514525166043987 no 215 4.74386557276112e-06 4 5532636 SGTC_398 bronopol 33.3 µM 4.40017278079805 0.0053925663936532 no 216 5.40823596536337e-06 6 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1346 1488-2224 62.4 µM 4.39618205659174 0.00542820575768007 no 217 5.50857698832832e-06 6 3722427 SGTC_509 pifithrin 175 µM 4.39332202699093 0.00545387602545437 no 218 5.58157903569233e-06 2 4817 A p53 inhibitor. SGTC_237 nikkomycin 200 µM 4.37937575925865 0.00558060311258945 no 219 5.95098767630579e-06 7 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3071 9117417 49.47 µM 4.37204349606201 0.00564827343374607 no 220 6.15444973186206e-06 10 45595590 YGL055W OLE1 SGTC_801 0866-0028 10.1 µM 4.36077659880862 0.00575367729530459 no 221 6.48008182808702e-06 7 6849771 SGTC_708 3448-5400 146 µM 4.35339835625998 0.00582364448896659 no 222 6.70216293178245e-06 13 3462195 SGTC_1818 st052136 56.3 µM 4.33529951616709 0.00599848066683559 no 223 7.27808938638519e-06 13 674169 SGTC_3130 9127414 49.47 µM 4.33022995377359 0.00604828001902516 no 224 7.44768560605411e-06 3 1494646 SGTC_2612 dictamnine 15.46 µM 4.32248728403593 0.00612504513398284 no 225 7.71399889287796e-06 27 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_842 0271-0008 11.1 µM 4.31552019777604 0.00619485724556284 no 226 7.96137457704523e-06 10 1221709 SGTC_1638 st008370 60.6 µM 4.31029616333605 0.00624766492017573 no 227 8.15180245637613e-06 15 24207134 SGTC_695 3505-6186 243 µM 4.28651625888481 0.00649311647797859 no 228 9.07484621980968e-06 6 1819379 SGTC_1511 0906-3109 28.5 µM 4.28457070802365 0.00651357058602134 no 229 9.15461868884837e-06 9 2882180 SGTC_982 1491-0518 27.5 µM 4.28374092605679 0.00652231163333557 no 230 9.18884465797297e-06 2 3091256 SGTC_163 TUB2.036 7.546 µM 4.26416161110919 0.00673159579492983 no 231 1.00327089824972e-05 44 15992207 YJR013W GPI14 SGTC_2329 6138490 200 µM 4.20489470458516 0.00740171131625893 no 232 1.30601865769305e-05 9 720019 SGTC_624 k048-0052 28 µM 4.19561044025336 0.0075118477114313 no 233 1.3606882046365e-05 4 6835531 SGTC_332 4112-0506 40.9 µM 4.1853825358615 0.00763484698323607 no 234 1.42343129221788e-05 19 2790355 SGTC_2004 4023728 41.89 µM 4.17598778582442 0.00774938571702384 no 235 1.4834786981723e-05 25 360084 YDR527W RBA50 SGTC_86 0417-1630 471.922 µM 4.17465347641303 0.00776577536211433 no 236 1.49219984571048e-05 26 3634867 SGTC_546 peri-Naphthalide 147 µM 4.16724027688412 0.00785739015510937 no 237 1.54154737425481e-05 22 223824 A penicillin ester. SGTC_2662 daunorubicin 22.37 µM 4.1653096080143 0.00788140550373657 no 238 1.55465157087827e-05 15 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_514 4466-0038 2.65 nM 4.15454675334254 0.00801647004526803 no 239 1.62966485486153e-05 36 5722064 SGTC_648 0375-0473 33.3 µM 4.1464535772296 0.00811936863125731 no 240 1.68832301255429e-05 5 1713139 SGTC_2157 5649910 96.377 µM 4.14118583057531 0.00818696599505727 no 241 1.72757442585168e-05 4 2858091 SGTC_197 4544-0043 41.561 µM 4.13701534044449 0.00824083319693867 no 242 1.7592629740681e-05 20 896523 SGTC_2790 5423970 71.43 µM 4.08358685982247 0.0089589707901494 no 243 2.21729213410785e-05 18 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_895 0964-0006 13.7 µM 4.08268795079814 0.008971508004713 no 244 2.22588909260809e-05 11 6738897 SGTC_1556 plumbagin 1.48 µM 4.07655552404819 0.00905744865521883 no 245 2.28538724358676e-05 18 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_16 erodoxin 22.806 µM 4.06352684712445 0.00924243053980511 no 246 2.41683799095018e-05 30 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3274 9138298 49.47 µM 4.05869328609655 0.00931189386598515 no 247 2.46740391924468e-05 4 17015756 SGTC_634 1611-4317 11.2 µM 4.04734823238852 0.00947673107399637 no 248 2.59005736670968e-05 9 2843522 SGTC_4 0960-0234 25.671 µM 4.0205935513171 0.00987560030584214 no 249 2.90258449306916e-05 12 6821112 SGTC_2051 5263410 176 µM 4.01035751961921 0.0100320365246267 no 250 3.03134383354727e-05 5 227584 SGTC_2696 st077691 74.316 µM 3.99290877196862 0.0103036926283167 no 251 3.26338419666251e-05 12 757133 SGTC_3196 9111891 49.47 µM 3.97246580555967 0.0106301055581639 no 252 3.55662248974722e-05 4 18891510 SGTC_2429 5902844 64.44 µM 3.96649302474629 0.0107271574228856 no 253 3.64689545880067e-05 7 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2370 9071495 200 µM 3.96385652903998 0.0107702427762426 no 254 3.68742926478688e-05 10 21791103 SGTC_294 k038-0071 157 µM 3.96016083548306 0.0108308910086711 no 255 3.74496505168498e-05 13 24152826 SGTC_2676 harmalol 100 µM 3.95181637860597 0.0109689221961891 no 256 3.87801225480382e-05 9 5459187 A monoamine oxidase inhibitor SGTC_61 0978-8327 98.565 µM 3.93140971211879 0.0113129475567887 no 257 4.22246057815714e-05 9 6150059 YHR072W ERG7 SGTC_1627 st003713 25.6 µM 3.92454855546948 0.0114307040118219 no 258 4.34462663382311e-05 6 16195070 YER133W GLC7 SGTC_1121 fusaric acid 630.51 nM 3.92260515502292 0.011464251070872 no 259 4.37983207936964e-05 3 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3322 9139058 2.11 µM 3.92136257305238 0.0114857453665183 no 260 4.4024830021331e-05 15 4908926 YPR165W RHO1 SGTC_854 0422-0053 192 µM 3.91869427879648 0.0115320200820374 no 261 4.45149764936269e-05 5 3596728 SGTC_2069 5228469 200 µM 3.91493481951934 0.011597492983525 no 262 4.52143168214641e-05 5 2835210 SGTC_2417 cerulenin 830 nM 3.91215800892065 0.0116460595716188 no 263 4.57375131895717e-05 14 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1253 0550-0034 176 µM 3.9112379692835 0.0116621900169888 no 264 4.59121211830787e-05 10 5969915 SGTC_1341 1486-1360 280 µM 3.89287494253026 0.0119882175642015 no 265 4.95316126802481e-05 6 3976547 SGTC_2459 5811157 9.22 µM 3.89230581152025 0.0119984472768693 no 266 4.96479853449985e-05 8 2870684 YBR192W RIM2 SGTC_777 1315-0167 517 µM 3.88882509177423 0.0120611755288839 no 267 5.03653386617639e-05 2 4221767 SGTC_1927 st060202 13.8 µM 3.88522080115718 0.0121264301910683 no 268 5.11184634552179e-05 8 688887 SGTC_1057 3448-5381 134 µM 3.86783655524599 0.012445482341864 no 269 5.49026103306794e-05 16 5497911 SGTC_3350 9150499 3.57 µM 3.84450525028138 0.0128850891406322 no 270 6.03979495098987e-05 16 4910996 YPR165W RHO1 SGTC_2584 androsterone 48.74 µM 3.83955108450885 0.0129801447163315 no 271 6.16297407367406e-05 32 2754130 A steroid. SGTC_922 1866-0035 480 µM 3.83863323581213 0.0129978218888765 no 272 6.1860537031263e-05 11 3156169 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 3.82863009336449 0.0131918293466501 no 273 6.44292558716977e-05 1 279621 SGTC_1727 st034309 9.9045 µM 3.82702359311762 0.0132232189073478 no 274 6.48510436848646e-05 16 870305 SGTC_1936 st074407 74.3 µM 3.81113826239318 0.0135370934171334 no 275 6.91641833604773e-05 12 809813 SGTC_3311 9131146 2.8755 µM 3.80914148102152 0.0135769987369275 no 276 6.97250751057325e-05 20 4900406 YPR165W RHO1 SGTC_855 0428-0020 25 µM 3.79577530679089 0.0138467427106599 no 277 7.35913798878097e-05 9 6812414 SGTC_1718 roemerine 11.9335 µM 3.79310726392976 0.0139011365831327 no 278 7.43869260357685e-05 16 235224 An aporphine alkaloid with mutagenic activity. SGTC_667 1498-1044 59 µM 3.78576132693525 0.0140518524733006 no 279 7.66193500905962e-05 9 6739982 SGTC_3166 9102297 49.47 µM 3.7650006908626 0.0144854336179889 no 280 8.32743108680385e-05 4 25237072 SGTC_745 0469-0705 296 µM 3.74407734372098 0.0149340157840457 no 281 9.05289390281622e-05 21 3486736 SGTC_852 0418-0143 439 µM 3.71828714134401 0.0155033279769175 no 282 0.00010028910126613 16 5369229 SGTC_1177 0983-0204 23.6 µM 3.70391118154303 0.0158286866410918 no 283 0.000106150308450388 13 766818 SGTC_1079 idarubicin 2.36 µM 3.70283700422815 0.0158532309732608 no 284 0.000106600934519366 8 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_551 k048-0028 34.9 µM 3.68910629956689 0.0161698556466454 no 285 0.000112521592041166 9 6836383 SGTC_2248 tofa 1.1 µM 3.68027280991672 0.0163764038330758 no 286 0.000116492279405439 34 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_993 3909-8757 62.7 µM 3.67848721840134 0.0164184286241313 no 287 0.000117310723250714 5 4288324 YLR208W SEC13 SGTC_326 k292-0812 17.5 µM 3.67785002356792 0.0164334476617507 no 288 0.000117604091964079 5 3579357 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 3.66031617386036 0.0168513698880719 no 289 0.000125952110965769 9 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_500 h-89 112 µM 3.65584053075002 0.0169594924294667 no 290 0.000128170338607155 12 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1082 camptothecin 424.86 nM 3.65455873294705 0.0169905671342338 no 291 0.000128812342471355 23 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1148 3909-7663 27.7 µM 3.6258552854765 0.017699283538689 no 292 0.000144003309215151 5 4084526 SGTC_2322 7413319 38.22 µM 3.60527385664655 0.0182228545363208 no 293 0.000155911963398865 30 1840400 SGTC_2196 6573537 42.6665 µM 3.59993343966927 0.018360846509683 no 294 0.000159149323432349 3 2903087 SGTC_2490 carminic acid 95.39 µM 3.57755508424572 0.0189488049569909 no 295 0.000173411572575827 9 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_475 α-linolenic acid 10 µM 3.56947356135418 0.0191650351958772 no 296 0.000178849656608232 9 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3019 9081971 49.47 µM 3.56770794548984 0.0192125544218528 no 297 0.000180058782685529 6 16451803 SGTC_911 3456-4043 236 µM 3.54452537216239 0.0198458304493859 no 298 0.000196660323546176 17 914281 SGTC_1266 0828-0227 32.9 µM 3.54213365157632 0.0199121616480561 no 299 0.00019845215902652 16 3913820 SGTC_2341 7987486 176.74 µM 3.51878480177657 0.0205696509431465 no 300 0.000216764105968085 8 1258686 SGTC_2183 6420625 130.508 µM 3.51083378351866 0.0207977043729691 no 301 0.0002233518072879 22 2897619 SGTC_985 1493-0307 8.71 µM 3.50415622298352 0.0209908825910042 no 302 0.000229028279085176 6 3278274 SGTC_2950 9072895 21.46 µM 3.50070979798119 0.0210911785059914 no 303 0.000232010419456338 11 17332245 SGTC_1137 ixabepilone 100 µM 3.477817112745 0.0217677316134972 no 304 0.00025275735302248 9 154225 A novel microtubule stabilizer. SGTC_3235 9132602 49.47 µM 3.45570000701038 0.0224386846261226 no 305 0.0002744329090344 7 4912240 SGTC_3011 9081274 71.4286 µM 3.44835604551197 0.0226652961874026 no 306 0.00028200501283135 5 6625322 SGTC_2822 7994718 71.43 µM 3.4461577839359 0.0227335016108068 no 307 0.000284309125572457 9 1018011 SGTC_2718 lomofungin 53.02 µM 3.43988712842047 0.022929012264679 no 308 0.000290978416920002 12 5351222 A RNA synthesis inhibitor. SGTC_3351 9150312 21.596 µM 3.43073425328356 0.0232169278927099 no 309 0.000300974993876871 16 4904905 SGTC_3208 9114115 49.47 µM 3.42579966473665 0.0233734104994158 no 310 0.000306496163794577 20 650895 SGTC_778 3456-2434 196 µM 3.41793880561783 0.0236245218353794 no 311 0.000315486459048358 10 5539063 SGTC_142 0335-0849 62.6745 µM 3.40028914285479 0.0241966068245133 no 312 0.000336573153386879 28 3889043 YPR107C YTH1 SGTC_1348 1493-0373 93.8 µM 3.39669221618237 0.0243146114874314 no 313 0.000341028178786409 10 3010129 SGTC_1665 st014639 11.4 µM 3.39395882816083 0.0244046087809265 no 314 0.00034445024387471 12 981133 YIL048W NEO1 SGTC_2006 4011487 200 µM 3.38447509653818 0.0247190335588209 no 315 0.000356572439312894 27 45595294 SGTC_602 3130-1533 38.1 µM 3.38385678660844 0.024739650551157 no 316 0.000357376373322665 17 720941 SGTC_2256 7954252 200 µM 3.37994095547283 0.0248705556659906 no 317 0.000362507016511625 18 2972920 SGTC_2952 9073731 13.78 µM 3.3720959377565 0.0251345603879526 no 318 0.00037299229030498 15 16457353 SGTC_1579 chlormadinone acetate 49.4 µM 3.36420722090828 0.0254024001272633 no 319 0.000383819414979849 9 45114258 A steroidal progestin. SGTC_591 4299-0174 154 µM 3.35917431434726 0.0255745246801297 no 320 0.000390878693625112 6 5509088 SGTC_1899 st063254 59.6 µM 3.34496020617013 0.0260659258856103 no 321 0.000411471884129909 11 3093813 SGTC_235 0330-0087 5 mM 3.34464728958262 0.0260768320642977 no 322 0.000411936354326056 10 46494818 YHR062C RPP1 SGTC_306 1672-3436 11.6 µM 3.33798756324038 0.0263098520367531 no 323 0.000421937631991666 6 6797378 SGTC_3331 9141060 1.957 µM 3.32533757066208 0.02675726190721 no 324 0.000441557701273784 13 4906567 YPR165W RHO1 SGTC_2525 harmine 47.85 µM 3.31969119460613 0.0269590064533934 no 325 0.00045058536042473 8 5280953 A monoamine oxidase inhibitor SGTC_1583 clindamycin 39.6 µM 3.31069790205354 0.0272829568542344 no 326 0.000465318096976619 11 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1808 st050063 61.5 µM 3.30033783262603 0.027660158583723 no 327 0.000482842526673345 3 4011993 SGTC_2597 laccaic acid a 100 µM 3.29957472409864 0.0276881137770925 no 328 0.00048415722370658 13 5491415 A textile dye. SGTC_2666 tannic acid 100 µM 3.29601723904449 0.0278187471619271 no 329 0.000490329987233402 21 16134267 A thiamine antagonist. SGTC_3210 9128157 49.47 µM 3.27717521859834 0.0285192300337121 no 330 0.000524256400097694 21 17590849 SGTC_1776 st049249 45.9 µM 3.26413276321264 0.0290126489031336 no 331 0.000548998507525523 17 1822314 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 3.26281365108362 0.0290629458864787 no 332 0.000551560147425441 9 3256 An antibiotic and ribosome inhibitor. SGTC_447 ml7 120 µM 3.25399209658929 0.0294011721653479 no 333 0.000568977228332294 4 4216 Selective myosin light chain kinase inhibitor. SGTC_1892 st058411 7.36 µM 3.25368147433246 0.0294131410171273 no 334 0.000569599680904867 11 3934738 SGTC_875 0709-0210 25.7 µM 3.24774001472163 0.0296428563070233 no 335 0.00058162753908629 17 6251364 SGTC_493 zm226600 134 µM 3.23565718144875 0.0301146100943623 no 336 0.000606815229353703 12 5240098 A potassium channel opener. YCR052W RSC6 SGTC_216 k038-0035 28.382 µM 3.23239167562703 0.0302431693250959 no 337 0.000613793342933409 28 4444231 YPR107C YTH1 SGTC_1448 4255-0083 152 µM 3.20068131618353 0.0315153818303607 no 338 0.000685515389559067 14 5399660 SGTC_2405 ticlatone 3.52 µM 3.1965044699805 0.0316862065487906 no 339 0.000695518355798812 29 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1302 1159-0335 255 µM 3.1884179061945 0.0320191056268241 no 340 0.000715268118263332 9 649284 SGTC_698 k064-0052 127 µM 3.18026389227092 0.032357700381777 no 341 0.000735704953003128 8 5088751 SGTC_1418 3966-3099 2.4 µM 3.17961839073908 0.0323846305141631 no 342 0.000737345576542757 8 740335 SGTC_2890 9046729 58.44 µM 3.17180926694376 0.032711892425266 no 343 0.000757462339319421 31 903329 SGTC_2491 paeonol 100 µM 3.15650945326874 0.0333609772734453 no 344 0.00079834855834029 3 11092 Increases levels of cortical cytochrome oxidase. SGTC_3064 1327-0027 10 µM 3.14552493811715 0.0338334991448596 no 345 0.000828945299914686 9 16000455 YPR107C YTH1 SGTC_2270 7924575 90.91 µM 3.1384156798473 0.0341422434840986 no 346 0.000849318995447448 16 1262135 SGTC_2914 7968218 45.32 µM 3.1372798566686 0.0341917845058871 no 347 0.00085261638321213 5 2977111 SGTC_2140 5586273 200 µM 3.11935822431344 0.0349813219230638 no 348 0.000906227304979718 17 854421 SGTC_188 3229-0966 278.469 µM 3.11468071069826 0.0351898341582866 no 349 0.000920720601026218 34 5722370 SGTC_2795 7780010 54.55 µM 3.11414949237538 0.0352135789281308 no 350 0.000922379980875304 13 953673 SGTC_3237 9133362 49.47 µM 3.10974976013179 0.0354107469108673 no 351 0.000936229523344323 7 43845137 SGTC_1513 0337-0559 19 µM 3.10914924806299 0.0354377281176623 no 352 0.000938134569481012 15 775073 SGTC_2375 9072683 200 µM 3.10323762278442 0.0357042402497584 no 353 0.000957079403975984 10 16798029 SGTC_2792 7535235 81.82 µM 3.09648809978114 0.0360105331609544 no 354 0.00097913861049885 25 1281891 SGTC_851 0394-0702 453 µM 3.09640424330142 0.0360143520551338 no 355 0.000979415587386462 34 762646 SGTC_1188 1403-0014 4.57 µM 3.0937540161056 0.0361352166193099 no 356 0.000988206400551303 21 9614867 SGTC_2180 6301957 200 µM 3.09054871099697 0.0362818392768678 no 357 0.000998935157124761 17 845462 SGTC_418 lividomycin a 100 µM 3.08097519643289 0.0367226695478075 no 358 0.00103161917661724 7 72394 An antibiotic. SGTC_534 k292-0788 63.4 µM 3.07849787225468 0.0368374532435367 no 359 0.00104023507695129 23 4146317 SGTC_1009 4106-0057 9.87 µM 3.06743350184906 0.0373536932892751 no 360 0.00107952746561841 20 2928005 SGTC_2949 9072542 2.23 µM 3.06663821998668 0.0373910259772889 no 361 0.00108240347527633 25 16457352 SGTC_3285 9112818 20.8695 µM 3.05003200346695 0.0381775535474179 no 362 0.00114408491137774 31 17017947 YPR165W RHO1 SGTC_2025 5147754 141 µM 3.04261695561509 0.0385330872089867 no 363 0.0011726532975144 12 315777 YLR208W SEC13 SGTC_1826 st055655 41.6 µM 3.04191241063597 0.0385670083540586 no 364 0.0011754014438131 7 676168 SGTC_1952 st077036 64.1 µM 3.04127944980527 0.0385975037436659 no 365 0.0011778753967348 21 2937007 SGTC_3236 9132701 49.47 µM 3.0392536252113 0.038695237953022 no 366 0.00118582549803209 13 24282524 SGTC_1419 3993-2473 62.6 µM 3.03776298767292 0.03876728119445 no 367 0.0011917066640838 14 704026 SGTC_2149 5554786 194.827 µM 3.028093935815 0.0392372482272491 no 368 0.00123050787326324 18 745063 YPR165W RHO1 SGTC_924 2046-0044 21.3 µM 3.02205825938351 0.0395329573088749 no 369 0.00125531111483262 19 3623589 SGTC_789 1309-1135 70.6 µM 3.02122191857588 0.0395740752154282 no 370 0.00125878385336364 6 3092424 SGTC_1793 st048256 72.231 µM 3.01900422518769 0.039683274435462 no 371 0.00126803497283291 10 672022 SGTC_3293 9120939 62.045 µM 3.01327802514654 0.039966365907027 no 372 0.00129221014846593 25 934087 SGTC_1933 st074711 15.9 µM 3.00203888460048 0.040526777325132 no 373 0.00134088958925037 22 17250958 SGTC_2497 7-hydroxyflavone 100 µM 2.99967536434252 0.0406454363686395 no 374 0.00135133746845288 12 5281894 SGTC_3005 9076496 71.4286 µM 2.99314679788175 0.0409746646398595 no 375 0.00138058451568596 6 21368410 SGTC_1623 st003709 20.3 µM 2.99070648478683 0.0410982808912512 no 376 0.00139166441455479 17 16192618 SGTC_1172 0370-0043 85 µM 2.9889469358394 0.0411875999256615 no 377 0.00139970372559019 14 376585 SGTC_2060 5238662 140 µM 2.9812634859916 0.0415794765558063 no 378 0.00143530844831751 16 790130 SGTC_1622 st003707 19.4 µM 2.97630116807216 0.0418341696815464 no 379 0.00145874098942478 14 10140899 SGTC_3318 9139014 38.6185 µM 2.97624630871619 0.0418369924062417 no 380 0.00145900198065593 20 16643984 SGTC_774 k060-0086 136 µM 2.96499374526915 0.0424192482419501 no 381 0.0015134454181551 16 5911235 SGTC_2043 5101342 149 µM 2.96342612658805 0.0425008812253162 no 382 0.0015211753881057 17 678451 SGTC_2311 7694451 200 µM 2.95198257898218 0.0431006541994151 no 383 0.00157870371946915 25 2163142 SGTC_2963 9082507 9 µM 2.94688275985444 0.0433701365977734 no 384 0.00160497440311945 22 16459611 SGTC_1451 4152-0210 104 µM 2.94674134785326 0.0433776283680323 no 385 0.00160570850200107 13 659563 SGTC_1067 clotrimazole 1.36 µM 2.94565235974406 0.0434353561385716 no 386 0.00161137192284758 33 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_925 2064-1272 59.6 µM 2.93734254964278 0.0438779080164679 no 387 0.00165519111427853 20 6815817 SGTC_2168 5727979 200 µM 2.92555159061774 0.0445120878670912 no 388 0.00171923078989895 16 695210 SGTC_3327 9140648 26.9345 µM 2.91533984683045 0.0450672776090488 no 389 0.00177650705237709 40 8029710 SGTC_1891 st059073 26.2 µM 2.90666801443125 0.0455431095003737 no 390 0.00182650331924092 14 688754 SGTC_2430 5571206 200 µM 2.90644470411652 0.0455554159016898 no 391 0.00182780751803003 33 1731771 SGTC_483 fpl-64176 144 µM 2.90510801486265 0.0456291353812827 no 392 0.00183563190213666 15 3423 SGTC_518 1021-0119 62.6 µM 2.90163459594567 0.0458211456688068 no 393 0.00185610634460715 21 1097762 SGTC_511 blebbistatin 171 µM 2.8901462871843 0.0464608478773317 no 394 0.00192531296492748 15 3476986 A myosin inhibitor. SGTC_1373 2887-0003 58.5 µM 2.87284968341556 0.0474374731857719 no 395 0.00203393807831063 32 776948 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.86482131030327 0.0478963378679811 no 396 0.00208622307791173 26 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2809 7964133 12.99 µM 2.86280869807341 0.0480119247516039 no 397 0.00209952000905163 26 1253665 SGTC_2648 atorvastatin 78.68 µM 2.85847557326398 0.0482615393870151 no 398 0.00212840940478163 19 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_396 dithiazanine 1.25 µM 2.85734183954859 0.048327020484941 no 399 0.00213602739360878 13 10578 An antihelmenthic. SGTC_1136 pergolide 1.05886 µM 2.85315381514331 0.0485695247068318 no 400 0.00216438317718306 39 47811 A dopamine receptor agonist. SGTC_2174 5790901 200 µM 2.84875564252726 0.0488252437808622 no 401 0.00219452881403645 26 786020 SGTC_1993 st073995 70.8 µM 2.84806803835425 0.0488653196244128 no 402 0.00219927599016966 15 3098394 SGTC_846 0335-0850 148 µM 2.83307413952127 0.0497457674350902 no 403 0.00230513459414215 16 6819598 SGTC_1463 k081-0032 34.1 µM 2.8246629686878 0.0502451886843275 no 404 0.00236651860692026 6 977755 SGTC_1271 0832-2808 169 µM 2.81273646799956 0.0509601776332535 no 405 0.00245609454433533 29 3663794 SGTC_2700 st077718 96.8 µM 2.79010158327131 0.0523393832063838 no 406 0.00263457532661855 19 904970 SGTC_3356 9151811 4.48 µM 2.77901590431801 0.0530255926566292 no 407 0.00272619277336051 13 1859254 YPR165W RHO1 SGTC_1785 bathophenanthroline 24 µM 2.77433577399149 0.053317428648242 no 408 0.00276572769876897 52 72812 An iron chelator. SGTC_2734 clemastine 41.6 µM 2.75515156718418 0.0545270121482597 no 409 0.00293324761032359 12 26987 Clemastine is a selective histamine H1 antagonist. SGTC_635 k038-0028 24.7 µM 2.75453945090874 0.0545659610427607 no 410 0.00293874018398978 36 4035102 SGTC_1003 4049-0218 100 µM 2.75279797447558 0.0546768913491882 no 411 0.00295441734853822 37 295161 SGTC_1317 1273-0028 910 nM 2.75021429057767 0.0548417978388469 no 412 0.0029778151443683 36 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2402 5553605 200 µM 2.74797052396984 0.0549853274472624 no 413 0.00299826998508883 24 6758546 SGTC_2765 myclobutanil 7.74 µM 2.74592781676601 0.0551162536290567 no 414 0.00301700190470997 33 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3218 9131285 49.47 µM 2.74143058392413 0.0554053692211346 no 415 0.00305861424451489 24 17156417 SGTC_1570 verbenone 133 µM 2.73860102690952 0.0555878870696625 no 416 0.00308506000277572 17 29025 A natural terpanoid with antifungal properties. SGTC_1353 1498-1206 8.11 µM 2.73031957660035 0.0561248020834144 no 417 0.00316364782825649 23 6756808 SGTC_2347 9049783 174.81 µM 2.72770595362476 0.0562950986624622 no 418 0.00318882154885211 18 6467988 YPL169C MEX67 SGTC_674 0498-0004 451 µM 2.72523041797572 0.0564567732292113 no 419 0.00321283131813403 50 4231473 SGTC_532 1548-0774 215 µM 2.72370761400878 0.0565564075553317 no 420 0.00322768139449461 25 5932993 SGTC_3122 9126309 49.47 µM 2.72339381106498 0.0565769563247301 no 421 0.0032307491999562 22 17591206 SGTC_2265 7929201 200 µM 2.72050050972186 0.0567666957556083 no 422 0.00325915856917023 18 1265108 SGTC_2130 NSC 7 2.4545 µM 2.71850796732971 0.0568976556146947 no 423 0.00327885382053916 10 21448 SGTC_110 0850-0284 111.64 µM 2.71547973190005 0.0570971418158052 no 424 0.00330899135775324 9 3906265 SGTC_32 0928-0142 34.1 µM 2.69049758217105 0.0587639250768779 no 425 0.00356727760155516 20 2244242 SGTC_768 0384-0033 77.3 µM 2.67828136212526 0.0595927634653331 no 426 0.00370005134418996 40 3965305 YMR134W ERG29 SGTC_529 4076-0302 30.3 µM 2.66882882846489 0.0602403578997452 no 427 0.00380581151886926 23 5816522 SGTC_2965 9082772 38.63 µM 2.66277690597783 0.0606578599569242 no 428 0.0038749388089808 10 16459634 SGTC_2465 5809242 33.21 µM 2.66072185639619 0.0608001446421508 no 429 0.00389866697797168 14 2731748 SGTC_2266 7929956 200 µM 2.65776838452718 0.0610050899752224 no 430 0.0039329965805292 21 2967153 SGTC_769 0302-0231 76 µM 2.64688269761344 0.0617651284099866 no 431 0.00406187635038855 51 571869 YER009W NTF2 SGTC_3159 9100096 49.47 µM 2.63815753700696 0.0623796393747306 no 432 0.0041678923808956 26 25236875 SGTC_608 k048-0125 159 µM 2.63600239925385 0.0625321570303333 no 433 0.00419445691875035 22 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_605 1315-0399 119 µM 2.62430618276848 0.0633649660366667 no 434 0.00434128466295538 29 24020461 SGTC_2543 pimpinellin 60.67 µM 2.62225910178919 0.0635116086890126 no 435 0.00436744976992215 14 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_123 0083-0120 66.675 µM 2.62169027457198 0.0635524034835589 no 436 0.00437474530582429 34 16001701 SGTC_1812 st052057 4.327 µM 2.61464151324055 0.0640596156365165 no 437 0.00446605750965859 28 3645418 SGTC_1 0258-0098 57.368 µM 2.61326418413781 0.0641590915525167 no 438 0.00448409745798494 35 6790032 YDR047W HEM12 SGTC_2622 2-methoxyxanthone 59.94 µM 2.60475029020347 0.0647766646496438 no 439 0.00459706203725841 19 71034 A hepatoprotective. SGTC_2343 7990716 14.84 µM 2.59801939270406 0.0652681635473624 no 440 0.00468815992142678 18 6456862 SGTC_966 1300-0360 30.2 µM 2.588856149579 0.0659419199503551 no 441 0.0048147655806817 47 70588 SGTC_426 0988-0037 14.6 µM 2.58531438908174 0.0662037785950288 no 442 0.00486451200286361 35 5383008 SGTC_814 3342-0569 96 µM 2.58397799088057 0.0663027936869811 no 443 0.00488340133433489 18 4346283 SGTC_2223 6903751 107.57 µM 2.58173328061125 0.0664693645756277 no 444 0.00491527635895092 24 5598863 SGTC_2736 butenafine 14.65 µM 2.57503167547778 0.0669685913773072 no 445 0.00501154535192777 29 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1199 1638-0010 4.46 µM 2.57446813988231 0.0670107030229555 no 446 0.0050197166150165 20 3111136 SGTC_3076 9116187 49.47 µM 2.57319817328905 0.0671056796251496 no 447 0.00503817463863435 13 27241210 SGTC_971 1315-0384 26.7 µM 2.56323173954647 0.0678546541784172 no 448 0.00518514026053112 21 6769120 SGTC_1211 1056-0033 32.3 µM 2.55335972097154 0.0686028817549538 no 449 0.00533446226659733 22 6741922 SGTC_2016 5121758 140 µM 2.54677142941488 0.0691057564342985 no 450 0.00543623106377771 51 2795203 SGTC_341 1486-1430 230 µM 2.53798604910922 0.0697807452604814 no 451 0.00557462143943786 63 2054753 YPL210C SRP72 SGTC_1686 st019653 115.5 µM 2.53701199539399 0.069855894127932 no 452 0.00559015615897497 23 97252 SGTC_2001 4023502 57.655 µM 2.53475250685307 0.0700304549099194 no 453 0.00562633979537773 20 108941 YCR052W RSC6 SGTC_1771 st048882 4.1505 µM 2.53252518545618 0.070202858835772 no 454 0.00566221170978381 35 4580403 SGTC_1615 st002656 86.5 µM 2.53066124554912 0.0703473862667261 no 455 0.00569238713629409 28 1584458 SGTC_107 0358-0022 2.6945 µM 2.52599540520053 0.0707101724489766 no 456 0.00576854950820909 17 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1938 st074717 56.4 µM 2.51884481400443 0.0712689448257842 no 457 0.00588702683461313 8 17250979 SGTC_1204 4049-0315 18.3 µM 2.51516208383427 0.0715580457063627 no 458 0.00594888356748715 33 588402 SGTC_327 1273-0057 3.96 µM 2.51500634763143 0.0715702910775023 no 459 0.00595151203435033 26 3108138 SGTC_1468 k284-1086 134 µM 2.5092002705977 0.0720279649785161 no 460 0.00605024291987847 42 15996457 SGTC_2273 7815444 169.05 µM 2.50495093859439 0.0723643454029409 no 461 0.00612341899124795 29 2824616 SGTC_2139 5578692 56.4705 µM 2.50427559641708 0.0724179166872879 no 462 0.00613512072773979 46 650991 YMR113W FOL3 SGTC_281 1672-3440 14.9 µM 2.49697142453672 0.0729992605935125 no 463 0.00626295250098222 17 6833000 SGTC_611 3453-1652 23.7 µM 2.49052862643214 0.0735150060874656 no 464 0.00637766099908742 53 1560575 SGTC_1761 st044296 37 µM 2.48324117040754 0.0741017194441079 no 465 0.0065096454984284 34 1826700 SGTC_3346 9158254 43.5805 µM 2.48039709605856 0.0743316639199566 no 466 0.00656180691281846 49 17639500 SGTC_1959 st077091 55.8 µM 2.47741945519952 0.0745729907179233 no 467 0.00661681371512871 54 821356 YKL052C ASK1 SGTC_2836 9010338 19.48 µM 2.4666316310143 0.0754523138308204 no 468 0.00681952941284295 35 2994051 SGTC_893 0958-0369 48.9 µM 2.46402126656249 0.0756662691243805 no 469 0.00686939797494435 28 6819948 SGTC_1552 6-methylflavone 10.6 µM 2.46376259162636 0.0756874962402334 no 470 0.00687435721226245 28 689013 SGTC_2073 5212005 126 µM 2.46363706990005 0.0756977983092958 no 471 0.00687676481588106 29 691789 SGTC_2987 9018338 71.43 µM 2.45769660772975 0.0761865782496902 no 472 0.00699156240343382 37 5055682 SGTC_1591 genipin 88.4 µM 2.45261694167776 0.0766064341629837 no 473 0.0070910636605798 33 442424 A DNA cross-linking agent. SGTC_1157 4092-0394 27.6 µM 2.44606254763568 0.0771507800150963 no 474 0.00722129713189835 27 3659885 SGTC_1516 st013856 110 µM 2.44531725999911 0.0772128621763921 no 475 0.00723623847779573 27 5281404 A mutagen and neurotoxin. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 2.44484030386947 0.0772526123436005 no 476 0.00724581467828142 33 5379071 SGTC_1213 1315-0166 115 µM 2.43655769399859 0.0779453777411133 no 477 0.00741390193564583 51 768401 SGTC_2448 5185112 27.17 µM 2.4245217715528 0.0789604622008258 no 478 0.00766428209142084 28 5718189 SGTC_363 0455-0021 3.06 µM 2.42393439949163 0.0790102549828936 no 479 0.00767668931792767 51 4597466 SGTC_898 1000-0849 28.3 µM 2.41543953539268 0.0797330442807649 no 480 0.00785811581380196 36 6751807 SGTC_1105 epirubicin 18.1 µM 2.40737910803013 0.0804234833484784 no 481 0.00803374043785456 42 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_255 tunicamycin 200.472 nM 2.40703521291633 0.0804530408317396 no 482 0.00804130954446111 40 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3081 9117243 49.47 µM 2.39814387101954 0.0812200959995281 no 483 0.00823919575972546 74 45595589 SGTC_2576 guaiol 23.12 µM 2.39702123266126 0.0813173369113872 no 484 0.00826448293954425 42 227829 SGTC_2231 micatex 6.853 µM 2.39033531072187 0.0818982792325738 no 485 0.00841649833986526 29 20737 An antifungal of unknown mechanism. SGTC_722 3534-0461 190 µM 2.38668722610383 0.0822165787569871 no 486 0.00850047413320636 19 658262 SGTC_999 SEC7.066 22.7 µM 2.38301000144799 0.0825383628287411 no 487 0.00858586389681271 44 740511 YDR170C SEC7 SGTC_1741 st038134 10.228 µM 2.38179582225383 0.0826448203259888 no 488 0.008614223437449 28 1272587 SGTC_340 k038-0059 454 µM 2.3802211519876 0.0827830390437495 no 489 0.00865112531440957 28 23733424 SGTC_2185 6113692 200 µM 2.3663878668905 0.0840047578416467 no 490 0.00898130737017397 37 874150 SGTC_3078 9116413 49.47 µM 2.36581747746084 0.0840554221842484 no 491 0.00899515563496538 32 17177322 SGTC_2522 biochanin a 4.94 µM 2.35868885739973 0.0846905519418426 no 492 0.00916981264467815 30 5280373 A possible chelator. SGTC_2532 xanthone 78.9 µM 2.35156366645052 0.0853289659224237 no 493 0.00934734502813655 16 7020 An insecticide. SGTC_1687 st020778 55.3625 µM 2.34085781822338 0.0862949733797292 no 494 0.00961974623100329 38 4259299 SGTC_2470 5664817 21.68 µM 2.33649474695978 0.0866909982996844 no 495 0.00973273553293759 23 2859561 SGTC_3096 9117468 49.47 µM 2.32312073971641 0.0879133852207865 no 496 0.0100863335597465 17 41316311 SGTC_1325 1431-0015 227 µM 2.32053658061103 0.0881510525414621 no 497 0.0101559342135659 24 1103340 SGTC_672 1441-0018 53.7 µM 2.30927384729056 0.0891924904994062 no 498 0.0104641949734736 37 251141 SGTC_3261 9137475 49.47 µM 2.30619302211323 0.0894789554422579 no 499 0.0105499246568546 10 17027690 SGTC_497 capsazepine 133 µM 2.3048454407628 0.0896044727492043 no 500 0.0105876155687796 28 2733484 A calcium channel blocker. SGTC_1313 1220-0047 237 µM 2.30415139769331 0.0896691688207882 no 501 0.0106070731950537 45 3528706 SGTC_1265 0819-1001 68.8 µM 2.30308044241605 0.0897690673567994 no 502 0.0106371587402594 37 3106768 SGTC_2356 9061756 188.97 µM 2.29990984237007 0.0900653054334892 no 503 0.0107266641850678 27 20104043 SGTC_1860 st056228 74.6 µM 2.29935174573743 0.0901175250628592 no 504 0.0107424868397249 44 688679 SGTC_2044 5102272 200 µM 2.29647399493878 0.0903871456715519 no 505 0.0108243971981438 45 592666 SGTC_2549 cedrol 20.94 µM 2.29481963422854 0.0905424160209622 no 506 0.0108717314768058 49 6708665 A sedative which affects the nervous system. SGTC_432 NS 1619 61.3 µM 2.29384540052881 0.0906339455059045 no 507 0.0108996902768134 38 4552 A K+/calcium channel activator. SGTC_1357 1503-1303 39.5 µM 2.28657115241957 0.0913195346427277 no 508 0.0111104333197487 47 292895 SGTC_3239 9133757 49.47 µM 2.27740021390166 0.0921893542460669 no 509 0.0113811686733832 13 17036923 SGTC_45 0kpi-0036 14.9 µM 2.27664021711947 0.0922617105486866 no 510 0.011403859602265 30 2795021 SGTC_606 k015-0008 38.6 µM 2.2702494592076 0.092871812968931 no 511 0.0115962258304947 31 1970475 SGTC_2830 7992007 71.43 µM 2.2685396390244 0.0930355479563897 no 512 0.0116481679312121 40 1952075 SGTC_1086 cerivastatin 2.18 µM 2.26070902017814 0.0937881467921853 no 513 0.0118886407729265 24 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1524 corynanthine 62.1 µM 2.25816806625386 0.0940333204125071 no 514 0.0119675916741769 43 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3060 1327-0027 12.5 µM 2.25771211390861 0.0940773647103565 no 515 0.0119818067499436 26 16000455 YPR107C YTH1 SGTC_2374 9071832 200 µM 2.25534232378798 0.0943065279687559 no 516 0.0120559249823269 35 17381698 SGTC_1635 st007035 42.4 µM 2.2505513862117 0.0947710778641714 no 517 0.0122069827009726 55 3716403 SGTC_2147 5545932 89.7195 µM 2.24651961505004 0.0951633206263442 no 518 0.0123353722915445 40 797404 SGTC_1621 st003705 32.4 µM 2.24082645783693 0.0957192303870841 no 519 0.0125186592147383 40 24207032 SGTC_1714 st033236 13.627 µM 2.23356612216127 0.0964316291108261 no 520 0.0127558175469133 35 2916566 SGTC_1387 3342-1166 1.8 µM 2.22277902558121 0.097497263493672 no 521 0.0131153520391247 25 3418228 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 2.21608157455198 0.0981632218784488 no 522 0.013342957948405 22 17037758 SGTC_1028 k015-0029 4.8 µM 2.2129039087683 0.0984803549118913 no 523 0.0134521355833173 43 4588309 SGTC_208 k072-0098 12.366 µM 2.20723734910583 0.0990477415468152 no 524 0.013648740855163 59 5948901 SGTC_669 0108-0021 26.2 µM 2.20067648938411 0.0997076560544442 no 525 0.0138794671789744 49 17201 SGTC_2640 pentamidine 10.38 µM 2.19937075835455 0.0998393734952092 no 526 0.0139257850609186 58 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_945 3381-0768 11.3 µM 2.19878062234243 0.0998989459745468 no 527 0.0139467625017854 45 1126236 YIL048W NEO1 SGTC_1947 st076332 61.6 µM 2.19802590616899 0.0999751701588101 no 528 0.0139736299338975 28 24208416 SGTC_662 k832-1615 104 µM 2.19629128236457 0.100150523195272 no 529 0.0140355506530803 45 5878478 SGTC_295 k015-0027 31 µM 2.19207694914006 0.100577485148646 no 530 0.0141869754314883 27 3887424 SGTC_1642 st009582 77.7 µM 2.19115745284759 0.100670817236137 no 531 0.0142202001666943 49 6739311 SGTC_2825 7998094 58.44 µM 2.1893865314929 0.100850749906361 no 532 0.0142843788739284 51 2987815 SGTC_360 0957-0399 1.01 µM 2.18464713218947 0.101333445070794 no 533 0.014457364650269 50 6752301 YPR165W RHO1 SGTC_2561 acetosyringone 100 µM 2.18385716867774 0.101414064124689 no 534 0.0144863725904894 43 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1752 st044819 83.042 µM 2.18057617973691 0.101749402664911 no 535 0.0146073892853232 43 441209 YML126C ERG13 SGTC_1872 amphotericin b 148 nM 2.1792156702888 0.101888692146331 no 536 0.0146578251809809 45 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2725 haloperidol 53.21 µM 2.17795873992704 0.102017500449114 no 537 0.0147045543425714 63 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1182 1222-0449 220 µM 2.17760386849547 0.102053888571694 no 538 0.0147177706481877 26 658318 SGTC_3029 9088683 49.47 µM 2.16700129069956 0.103145424894416 no 539 0.0151173778526916 39 25236615 SGTC_1845 st056753 3.01 µM 2.1626539284042 0.103595428621571 no 540 0.0152839035526425 50 5375839 SGTC_1769 st044406 64.4 µM 2.16017107742802 0.103853071536602 no 541 0.0153797141378913 67 670903 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 2.15782991862646 0.104096436634299 no 542 0.0154705289160864 49 165521 SGTC_3111 9122088 49.47 µM 2.15772876523958 0.104106960910109 no 543 0.0154744630614542 29 16876704 SGTC_1475 4092-1048 11.7 µM 2.15711564606859 0.104170768018989 no 544 0.0154983274078028 44 2881759 SGTC_419 nsc-638432 893 µM 2.15621448104764 0.104264603413097 no 545 0.0155334606546609 38 368090 SGTC_1218 1348-1416 30.7 µM 2.15556125041822 0.104332660491595 no 546 0.0155589705272652 47 6787668 SGTC_3267 9137951 49.47 µM 2.15324739453156 0.104573989415682 no 547 0.0156496203438362 25 16643986 SGTC_2088 5278280 127.392 µM 2.14469736748322 0.105469241613939 no 548 0.015988525761854 36 791502 SGTC_36 0335-0881 14.2 µM 2.14106263653837 0.105851499782049 no 549 0.0161344936220515 91 23828853 SGTC_2177 5811945 192 µM 2.13948033927687 0.106018219639368 no 550 0.0161983932700268 36 5343475 SGTC_2246 7293507 91.5585 µM 2.13884719306207 0.106084984656999 no 551 0.0162240229768067 57 887656 SGTC_776 4476-4378 112 µM 2.13570710159088 0.106416554992336 no 552 0.0163516476020184 39 2892008 SGTC_1103 duloxetine 36.1 µM 2.13240192183633 0.106766365074612 no 553 0.0164869097719333 60 60835 A selective serotonin reuptake inhibitor. SGTC_1573 oleylamine 1.06 µM 2.12665542858374 0.107376530375916 no 554 0.0167243617059454 39 5356789 An amine of the fatty acid oleic acid. SGTC_972 1319-0219 195 µM 2.10885346253822 0.109282696791132 no 555 0.0174786161109804 60 23903702 SGTC_356 1634-0012 32.5 µM 2.10416921628931 0.109788283699197 no 556 0.0176818443938961 49 735457 SGTC_2780 5215298 71.43 µM 2.09702001942728 0.110563154289539 no 557 0.0179959016024654 69 2834131 SGTC_1607 st000305 50.6 µM 2.09536794659062 0.110742771593085 no 558 0.0180691483092762 35 5457690 SGTC_858 0438-0351 2.77 µM 2.09472155371632 0.110813105849593 no 559 0.018097876036355 49 2799119 SGTC_139 0099-0334 718.624 µM 2.09359686127534 0.11093556034559 no 560 0.0181479537035193 44 97690 SGTC_2121 5257820 149.641 µM 2.08779538186904 0.111568754678762 no 561 0.0184081481680392 35 791256 SGTC_366 0181-0206 4.31 µM 2.0808047080859 0.112335172152502 no 562 0.0187258925282644 50 274874 SGTC_1131 3454-3128 32.3 µM 2.07963662262471 0.112463600302019 no 563 0.0187794376115464 56 710982 SGTC_3022 9087993 49.47 µM 2.07276083421096 0.113221702618275 no 564 0.0190972715380125 32 17173644 SGTC_2761 levamisole 97.89 µM 2.05850494695297 0.114805110522237 no 565 0.0197708434418795 39 26879 An alkaline phosphatase inhibitor. SGTC_1154 4088-0362 150 µM 2.04826264529934 0.115952411049074 no 566 0.0202671355408948 47 6618304 SGTC_2099 5377090 177.372 µM 2.04814854110353 0.115965238215686 no 567 0.0202727234234386 55 2243829 SGTC_531 3788-1495 174 µM 2.04329678323137 0.116511587072382 no 568 0.0205115339237116 37 2896655 SGTC_226 1,3-diallylurea 8.28947 mM 2.03904222514727 0.116992186492872 no 569 0.0207229067577385 64 74537 YKL182W FAS1 SGTC_3062 9077494 49.47 µM 2.03186032961413 0.117806645181527 no 570 0.0210838987945572 47 16459633 SGTC_652 0437-0092 114 µM 2.02982917902761 0.118037712725749 no 571 0.0211869529363551 44 3091274 SGTC_120 rhodamine 6G 52.259 µM 2.01008843611696 0.120300165072529 no 572 0.0222109148743488 98 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1626 st003712 1.76 µM 2.00856458555786 0.12047607250227 no 573 0.0222916651132158 62 24207035 SGTC_1624 st003710 6.25 µM 2.0071195210896 0.120643052435606 no 574 0.0223684690646099 41 24207033 SGTC_2864 9034755 47.6 µM 1.99396832622034 0.122170189134967 no 575 0.0230777580251658 45 4930451 SGTC_1295 1013-0063 9.78 µM 1.98601447748583 0.12310036197064 no 576 0.0235158581973205 43 6826038 SGTC_3074 9116018 49.47 µM 1.98321967666172 0.123428379013723 no 577 0.0236714484666669 52 17027303 SGTC_499 genistein 192 µM 1.98047002066316 0.123751694595235 no 578 0.023825369388881 28 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1935 st074532 41.6 µM 1.97799943422575 0.124042701366982 no 579 0.0239643852424508 57 2829742 SGTC_946 3434-1334 87.4 µM 1.97400898048701 0.124513741770079 no 580 0.0241903609043161 59 4047976 SGTC_882 0843-0131 351 µM 1.97009191705956 0.124977333939417 no 581 0.0244139185613048 77 5425421 SGTC_1620 st003704 16.5 µM 1.96963841235448 0.125031084891813 no 582 0.0244399130034743 53 2834414 SGTC_2508 celastrol 40.54 µM 1.96725092614952 0.125314324305986 no 583 0.0245771447717824 39 122724 Celastrol is a natural product and antioxidant. SGTC_960 1222-0186 7.7 µM 1.96410859943005 0.125687796550478 no 584 0.0247587495864163 60 3126296 SGTC_2983 9022671 12.99 µM 1.96201503723819 0.125937051500595 no 585 0.024880366789077 47 6405161 SGTC_302 1094-0063 18.9 µM 1.96020659259076 0.126152638285707 no 586 0.0249858241262827 77 5440289 SGTC_2892 9047358 58.44 µM 1.95284990366699 0.127032288923947 no 587 0.0254186916308754 46 6466771 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.94368035042389 0.128134670739622 no 588 0.0259670048016554 32 77254 SGTC_128 0906-2981 13.371 µM 1.93772057452801 0.12885471953408 no 589 0.0263286611967615 72 6740226 SGTC_465 cgp-37157 41 µM 1.93481066577166 0.129207307028013 no 590 0.0265067668916018 34 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1565 sinapyl alcohol 95.1 µM 1.93278185740282 0.129453528795265 no 591 0.0266315381134563 47 5280507 A phenol propionate derived from cinnamic acid. SGTC_2108 5365811 200 µM 1.92557659904359 0.130330605476016 no 592 0.0270786314918982 54 780283 SGTC_687 k029-0044 34.9 µM 1.91504396643479 0.131620096850672 no 593 0.0277434484041874 30 5829338 SGTC_1447 4239-0816 81.9 µM 1.91432174567159 0.131708838505816 no 594 0.0277895287796063 71 1341554 SGTC_914 3820-6779 408 µM 1.91356162513624 0.1318022816148 no 595 0.027838096162086 45 2893481 SGTC_1087 pterostilbene 9.05 µM 1.9125849179708 0.131922417272146 no 596 0.0279006059893213 64 5281727 Similar to reservatol, lowers cholesterol. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.90933653761319 0.132322513534065 no 597 0.0281093458896094 86 16725076 SGTC_1409 3909-8004 61.9 µM 1.90856096131211 0.132418163208504 no 598 0.0281593760102238 54 2119279 SGTC_2887 9044784 58.44 µM 1.90398396190458 0.132983602079113 no 599 0.0284561364840814 86 6465546 SGTC_1247 0448-0043 5.84 µM 1.89847466048665 0.133666418468767 no 600 0.0288167913447392 67 3089013 YGL099W LSG1 SGTC_1029 k015-0030 64.7 µM 1.89643399733403 0.133919946614718 no 601 0.0289513399567939 63 2208316 SGTC_2301 7769476 200 µM 1.89480898240514 0.13412207162341 no 602 0.0290588563808101 65 977820 SGTC_474 dl-dihydrosphingosine 5 µM 1.89374217856625 0.134254878290913 no 603 0.0291296199276477 57 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1085 doxorubicin 7.67 µM 1.89314732166518 0.134328971379315 no 604 0.0291691402831465 76 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2652 actinonin 100 µM 1.89263322836995 0.134393027479895 no 605 0.0292033308388132 57 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1675 st018485 24.5 µM 1.89083139043453 0.134617702314577 no 606 0.0293234277185948 71 3323024 SGTC_2956 9076196 2.52 µM 1.88182486680358 0.135744607923256 no 607 0.0299298991665394 52 16423868 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.8814692428766 0.13578923616582 no 608 0.0299540576946415 67 688803 SGTC_2300 7976697 71.57 µM 1.87748956823244 0.136289342118011 no 609 0.0302255128812617 45 2236109 SGTC_2897 9048598 12.99 µM 1.86651253810796 0.137675297137443 no 610 0.0309848457676684 25 6467404 SGTC_3291 9121177 71.43 µM 1.86372990168767 0.138028154478538 no 611 0.0311798220250112 42 17015612 SGTC_2938 9059746 27.26 µM 1.86246485405283 0.138188774943745 no 612 0.0312687974998644 66 6471769 SGTC_3306 9127676 59.7925 µM 1.86128643789638 0.138338510594768 no 613 0.0313518686710502 47 41905287 SGTC_1539 benzyladenosine 56 µM 1.85885340329859 0.13864801433323 no 614 0.0315239602174395 58 92208 A nucleotide analog. SGTC_164 4100-3994 89.624 µM 1.85641491124035 0.138958685281617 no 615 0.0316972204781508 69 4615967 SGTC_2743 auranofin 4.32 µM 1.85063643177746 0.139696771419211 no 616 0.0321109374123778 41 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_116 0155-0182 31.788 µM 1.85055613174325 0.139707046898415 no 617 0.0321167178431931 58 771486 SGTC_1384 3089-0840 101 µM 1.84818473210537 0.140010731345335 no 618 0.0322878116802924 33 1069836 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.84695302247721 0.140168642510743 no 619 0.0323769745475061 67 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3145 9085516 49.47 µM 1.84553548812278 0.140350526996225 no 620 0.0324798405314822 70 25236195 SGTC_1036 k216-0215 33.5 µM 1.83822976660352 0.141290468421377 no 621 0.0330142776461655 48 622330 SGTC_2037 5169046 200 µM 1.83055693586636 0.14228222582098 no 622 0.0335833506210465 56 5718022 SGTC_492 tmb-8 126 µM 1.82930789822552 0.142444115810135 no 623 0.0336767480614739 46 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2767 sibutramine 71.45 µM 1.82607104291883 0.142864230013599 no 624 0.033919780673744 45 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1309 pyrazolanthrone 13.4 µM 1.82550431690514 0.142937871925182 no 625 0.0339624801706411 71 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3169 9102970 49.47 µM 1.82517356336089 0.142980862788153 no 626 0.0339874209421155 45 17027839 SGTC_2326 6164455 177.58 µM 1.82457839446454 0.143058243977261 no 627 0.0340323381314144 75 2888790 SGTC_1037 k284-1091 78.7 µM 1.82098542071697 0.143525987227951 no 628 0.0343045365431515 54 3334711 SGTC_824 1304-0008 100 µM 1.81262883437105 0.144617859675484 no 629 0.0349445437153492 70 768245 SGTC_1073 triclabendazole 3.09 µM 1.81095931182632 0.14483666853299 no 630 0.035073575118938 59 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2808 7946468 45.46 µM 1.79851011690313 0.146475296139128 no 631 0.0360481034415274 74 2970879 SGTC_1474 0330-0125 5.35 µM 1.79802179237516 0.146539824596635 no 632 0.0360867772067274 54 X1474 SGTC_1058 3448-5425 97.3 µM 1.79678686652269 0.146703095998898 no 633 0.0361847310769223 75 7279705 SGTC_1466 k213-0079 57.5 µM 1.7940825028648 0.147061070170036 no 634 0.0364000006794634 94 3657981 SGTC_931 2812-0076 566 µM 1.79304962470976 0.147197945757166 no 635 0.036482494753623 61 3450959 SGTC_1288 0973-0013 65.5 µM 1.79212185070506 0.147320965872025 no 636 0.0365567247183816 57 4315430 SGTC_1843 st055809 45.5 µM 1.78880476675304 0.147761364938826 no 637 0.0368231315003932 66 16413835 SGTC_3276 9139060 49.47 µM 1.78640264093466 0.148080837639402 no 638 0.0370170441650662 80 4870619 SGTC_2257 7960413 200 µM 1.7847253427727 0.148304185164527 no 639 0.0371529390768628 75 2974689 YIL048W NEO1 SGTC_2726 cimetidine 79.27 µM 1.78253947721752 0.148595591099818 no 640 0.0373306497468411 53 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_52 0329-0193 875 nM 1.78178153336261 0.148696724761855 no 641 0.0373924324102926 61 3739292 SGTC_1376 2910-0861 41.3 µM 1.7793761931754 0.149017977784459 no 642 0.0375890534202242 62 1112859 SGTC_2777 climbazole 1.536 µM 1.77868082546532 0.149110936207589 no 643 0.0376460522693483 77 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1402 3909-7673 35.9 µM 1.76888414933919 0.150424695662865 no 644 0.0384566049442717 49 5328014 SGTC_1978 st071761 42 µM 1.76663012814424 0.150728053666718 no 645 0.0386450959637379 75 5147680 SGTC_1625 st003711 30.1 µM 1.76353137087482 0.151145765191584 no 646 0.0389054555543533 64 24207034 YER133W GLC7 SGTC_3317 9138495 8.753 µM 1.75791836270628 0.15190435621993 no 647 0.0393807004617653 86 17020139 SGTC_804 1595-0054 20.9 µM 1.7556970817451 0.152205256904839 no 648 0.0395700726876364 63 761523 Stimulates phospholipase C. SGTC_896 0964-0007 44.5 µM 1.75512345654907 0.15228302596529 no 649 0.039619096448849 80 6756758 SGTC_2259 7964009 200 µM 1.74035266302419 0.154294656455598 no 650 0.0408985560495263 53 313134 SGTC_1237 0330-0133 46.1 µM 1.73743921282335 0.154693503928773 no 651 0.0411548374176026 90 X1237 YHR072W ERG7 SGTC_694 1315-0438 43.2 µM 1.73017466944633 0.155690974908381 no 652 0.0417995362910982 56 6793154 SGTC_2849 9019321 12.99 µM 1.72993806398129 0.155723533606849 no 653 0.0418206708170652 70 16489627 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.7282142659095 0.155960876748133 no 654 0.041974908504535 92 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1114 scopoletin 1.73284 µM 1.72497339449782 0.156407745111522 no 655 0.0422661336702764 61 5280460 A coumarin with genotoxic properties. SGTC_2677 mitomycin C 100 µM 1.72321904042045 0.156649996089535 no 656 0.0424244608828659 70 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2702 st077768 96.8 µM 1.71940113416225 0.157178047007514 no 657 0.0427706779368597 55 6484119 SGTC_3094 9117742 49.47 µM 1.71928282949652 0.157194428286447 no 658 0.042781442464522 82 17149698 SGTC_929 2805-0021 398 µM 1.71844417266269 0.157310586674649 no 659 0.0428578145503843 74 3098024 SGTC_1307 1187-1599 12.2 µM 1.71801422128586 0.157370159079113 no 660 0.0428970106726589 93 1538471 SGTC_513 4245-1575 41.7 µM 1.7174507361865 0.157448255851056 no 661 0.0429484241297066 114 719745 SGTC_1838 st055369 84.5 µM 1.70854560831658 0.158685852437027 no 662 0.0437675756262478 66 676036 SGTC_1416 3966-0321 25.3 µM 1.70268711488371 0.159503509620081 no 663 0.0443133187341435 76 582530 YLR208W SEC13 SGTC_1487 3970-0795 2.82 µM 1.6961017180175 0.160425905651326 no 664 0.0449333091796809 82 3765103 SGTC_1701 st028638 40.4 µM 1.67957496357592 0.162756074329725 no 665 0.046520021136554 56 3490878 SGTC_1139 k015-0024 46.9 µM 1.67670882403764 0.163162410733103 no 666 0.0467997171298862 64 2766652 SGTC_1483 3453-0561 55.9 µM 1.67616479191334 0.163239613270102 no 667 0.0468529592386135 90 4546991 SGTC_1118 chelidonine 707.474 nM 1.67588664707408 0.163279093429676 no 668 0.0468801988536521 53 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_393 acivicin 6.25 µM 1.66960684981101 0.164172105176517 no 669 0.0474985871399239 86 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1479 0549-0158 134 µM 1.66620968724145 0.164656512782838 no 670 0.0478358285928602 77 5440202 SGTC_1256 0570-0116 285 µM 1.66594347716616 0.164694511252451 no 671 0.0478623364619843 88 410638 SGTC_3240 9133527 49.47 µM 1.66532025273278 0.164783491690892 no 672 0.0479244400298507 62 17617455 SGTC_1749 st037932 54.2 µM 1.66075044552202 0.165436893875325 no 673 0.0483817886815911 90 594497 SGTC_1915 st067105 30.6 µM 1.64810921131339 0.167253086554911 no 674 0.0496651312189999 105 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3214 9129694 49.47 µM 1.6434910870417 0.167919775204305 no 675 0.0501406839727018 94 17158655 SGTC_3059 1327-0034 3 µM 1.64139854325807 0.168222424570905 no 676 0.0503573560437766 87 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_373 0844-0104 25.9 µM 1.6407171576606 0.168321050609841 no 677 0.0504280708117705 103 5375804 SGTC_3278 9139605 49.47 µM 1.63692895903902 0.168870045161873 no 678 0.0508226571036959 84 7958859 SGTC_553 k007-0256 45.7 µM 1.63469266507957 0.169194673482107 no 679 0.0510567454522145 91 6287000 SGTC_675 1309-0189 238 µM 1.63446796397094 0.169227314025474 no 680 0.0510803138368776 81 4246530 SGTC_2440 5628896 157.78 µM 1.63435962388421 0.169243053172816 no 681 0.0510916804737396 65 5522048 SGTC_1684 st024538 14.6195 µM 1.63175819877199 0.169621258372458 no 682 0.0513652172086107 69 6732859 SGTC_3216 9129716 49.47 µM 1.61814210184824 0.171609655621611 no 683 0.0528159884907599 74 8056934 SGTC_3126 9127922 49.47 µM 1.61543695184286 0.172006462545333 no 684 0.0531080517489546 125 45595682 SGTC_625 k213-0058 121 µM 1.61243383778656 0.172447662033965 no 685 0.0534337832379442 126 3655420 SGTC_2874 9043904 71.43 µM 1.61068801293992 0.172704479615559 no 686 0.0536238698414018 91 4463428 SGTC_1548 st061468 90.8 µM 1.60966657675966 0.172854849820372 no 687 0.0537353326534924 52 390799 SGTC_536 3852-0578 10.6 µM 1.60617573662951 0.173369381663233 no 688 0.0541176514322263 85 2869208 SGTC_26 0302-0163 425.158 µM 1.59408097052706 0.175159619477982 no 689 0.055458950246822 106 3100915 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.59296717195357 0.175325068788075 no 690 0.0555837778553869 93 390807 SGTC_837 0091-0265 12.5 µM 1.59237537575585 0.175413017505872 no 691 0.055650192853817 100 759367 SGTC_2224 6650123 117.647 µM 1.59116117637819 0.175593551082838 no 692 0.0557866538223341 73 2908370 SGTC_3221 9128209 49.47 µM 1.58977517100714 0.175799773541191 no 693 0.0559427462221504 79 16460723 SGTC_1614 st002383 48.6 µM 1.58704292758807 0.176206750604216 no 694 0.0562514612472611 61 1947235 SGTC_1023 4482-3888 16 µM 1.58548418277825 0.1764391979199 no 695 0.0564281839325804 101 3303168 SGTC_628 1636-0253 16 µM 1.57558305224284 0.177920226884761 no 696 0.0575609622170969 97 4456143 SGTC_2907 7721985 69.9 µM 1.57214934166541 0.17843567315577 no 697 0.0579579603373898 81 3267881 SGTC_1774 st048371 48.465 µM 1.56528055104096 0.179469591070016 no 698 0.0587585706917206 116 4242727 SGTC_293 4049-0273 38.5 µM 1.5567496956571 0.180758921199792 no 699 0.0597649623837396 93 1380311 SGTC_1545 lovastatin 49.4 µM 1.55304219543085 0.181321068354458 no 700 0.0602065271534561 116 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2936 9038235 15.59 µM 1.55017400057654 0.181756706591898 no 701 0.060549879182498 97 4749415 SGTC_760 0568-0725 82.9 µM 1.55009880828631 0.18176813603841 no 702 0.0605589010263657 80 3916171 SGTC_715 0868-0130 184 µM 1.54980460702681 0.181812859805444 no 703 0.0605942104685827 65 2876258 SGTC_2308 7584454 197.62 µM 1.54882227571192 0.181962241303509 no 704 0.0607122245666668 103 893577 SGTC_2084 5306078 60.6385 µM 1.54620601558279 0.182360465925302 no 705 0.0610274105836005 97 679340 SGTC_2866 9034245 58.44 µM 1.54276966231007 0.182884344681907 no 706 0.0614433363919599 68 6462273 SGTC_1802 st050112 57.9 µM 1.53833173592637 0.183562303485981 no 707 0.0619837619399948 80 4662563 SGTC_274 sirtinol 40.1 µM 1.53761443277511 0.183672028992265 no 708 0.0620714582171154 98 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_63 0099-0242 26.702 µM 1.53436196486512 0.184170069983107 no 709 0.0624703146506914 124 3898502 YLR359W ADE13 SGTC_2878 9043973 25.97 µM 1.5313224790704 0.184636256664655 no 710 0.0628448562892593 64 6465167 SGTC_1920 st075728 45.7 µM 1.52612159213207 0.185435652349408 no 711 0.0634897928120466 88 3400306 SGTC_1315 1237-0019 3.69 µM 1.51977826265371 0.18641354891814 no 712 0.0642833570580625 85 825140 SGTC_902 1120-0002 2.07 µM 1.51917995533196 0.186505949385711 no 713 0.0643586026740699 111 3280475 SGTC_96 0929-0093 37.281 µM 1.51913560891832 0.186512799217995 no 714 0.0643641825867296 110 6991579 SGTC_2366 9070441 60.58 µM 1.51869514407024 0.18658084272361 no 715 0.0644196247380746 90 6837235 SGTC_2320 7373003 200 µM 1.51777180751933 0.186723530670296 no 716 0.0645359672890204 97 5415828 SGTC_1435 4092-0789 56.7 µM 1.51583565074523 0.187022954192495 no 717 0.0647804574670668 116 2248285 SGTC_707 0865-0008 204 µM 1.51574779320256 0.187036548261146 no 718 0.0647915688032445 106 723043 SGTC_2155 5570423 76 µM 1.51376103722457 0.187344119278715 no 719 0.065043228970868 86 797402 SGTC_47 0149-0135 24.25 µM 1.50964070806379 0.187982986114226 no 720 0.0655675640501955 101 5239155 SGTC_91 0417-1751 58.384 µM 1.50585636112715 0.188570941526707 no 721 0.066052025574967 103 6795624 SGTC_654 1124-0271 80.9 µM 1.50504914639177 0.188696501085478 no 722 0.0661557209202733 101 5403748 SGTC_716 1683-5115 658 µM 1.50278465384066 0.189049010321628 no 723 0.0664472922540772 99 723597 SGTC_1394 3474-0001 65.7 µM 1.5014406519058 0.18925842021912 no 724 0.0666208130253036 63 5017666 YIL048W NEO1 SGTC_1084 voriconazole 435 nM 1.50107604236346 0.189315254908425 no 725 0.0666679472886099 104 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1467 k284-1082 293 µM 1.50062266280227 0.189385941564072 no 726 0.0667265931346318 96 3334705 SGTC_2507 purpurin 79.67 µM 1.49851199192111 0.189715231215672 no 727 0.0670001396667292 95 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2170 morpholine 200 µM 1.49638067255807 0.190048099363028 no 728 0.067277241600148 82 121171 Reacts with secondary amines. SGTC_3031 9088762 49.47 µM 1.49227254209158 0.190690716619261 no 729 0.0678138559387442 99 205253 SGTC_1089 terbinafine 2.25 µM 1.49204429242117 0.190726459801231 no 730 0.0678437671441784 87 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2870 9038528 12.99 µM 1.4916618873312 0.19078635245205 no 731 0.0678939026344045 87 6463316 SGTC_449 xestospongin c 11.1929 µM 1.49115151325314 0.190866305705936 no 732 0.0679608601585576 92 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_368 fentichlor 4.58 µM 1.48899314840731 0.191204654130019 no 733 0.0682445864827347 93 7329 A pesticide. SGTC_957 1187-1561 14.1 µM 1.48762126943449 0.191419902894408 no 734 0.0684254005011036 101 1538454 SGTC_2733 amorolfine 100 µM 1.487174711321 0.191490000193494 no 735 0.0684843366497314 99 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2692 st077426 47.7 µM 1.48629730765443 0.191627774153586 no 736 0.0686002492767899 112 25238571 SGTC_630 4356-0227 183 µM 1.48438622340984 0.191928071464991 no 737 0.0688532437383566 135 779312 SGTC_538 2922-0838 53.3 µM 1.48414585582719 0.191965861892927 no 738 0.0688851151039864 118 777039 SGTC_2323 6148992 148.28 µM 1.47920283565048 0.192744009627795 no 739 0.0695430559617732 91 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_254 nsc-64875 3.808 µM 1.47634697724141 0.193194466099005 no 740 0.0699253844965272 79 56993 SGTC_3197 9113331 49.47 µM 1.46612049028522 0.194812760276672 no 741 0.0713077322254207 106 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1275 0867-0008 21.1 µM 1.46531890581179 0.194939954818144 no 742 0.0714169653921236 88 3422836 SGTC_2442 5158906 48.48 µM 1.46029455786842 0.195738362462857 no 743 0.0721045685460188 97 1893835 SGTC_439 amiodarone 34.4 µM 1.45660635303388 0.19632570801106 no 744 0.0726125365006007 106 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2630 antimycin a 100 µM 1.45583918509672 0.196448013374454 no 745 0.0727185402906208 113 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2764 methyldopa 94.69 µM 1.45277611081311 0.196936802516144 no 746 0.073142963415513 90 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1243 0416-0003 5.65 µM 1.45064066982157 0.197278000010351 no 747 0.0734399721387997 98 2141977 SGTC_2663 amphotericin b 100 µM 1.44936826204549 0.197481473283172 no 748 0.0736173835401115 125 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2951 9072950 58.06 µM 1.44648477592981 0.197943046683007 no 749 0.0740206395185026 110 16488155 SGTC_222 nsc-310342 10.666 µM 1.44427136880102 0.198297799033579 no 750 0.0743313281101976 82 432556 SGTC_131 0141-0277 33.849 µM 1.4417155658898 0.19870790564101 no 751 0.0746913152802909 122 1547771 SGTC_3231 9132313 49.47 µM 1.44166536902704 0.198715965395724 no 752 0.0746983988522522 100 4905967 SGTC_795 0685-0265 78 µM 1.44085945294493 0.198845392618778 no 753 0.0748121965678763 131 302754 SGTC_808 0711-0032 135 µM 1.44078564232022 0.198857248879084 no 754 0.0748226254527452 116 4252555 SGTC_1412 3909-8563 178 µM 1.44007374741535 0.198971623006742 no 755 0.0749232677814426 107 23767530 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.43754076803148 0.199378896713645 no 756 0.0752821987570134 107 5377381 SGTC_488 nitrendipine 139 µM 1.4359292560329 0.199638270200033 no 757 0.0755112363110127 93 4507 Dihydropyridine L-type calcium channel blocker. SGTC_620 0109-0052 432 µM 1.43490881856573 0.19980261494721 no 758 0.0756565412134625 107 493037 SGTC_800 3448-7362 155 µM 1.43340499154727 0.200044959421391 no 759 0.0758710663752356 165 15991913 SGTC_682 0kpi-0099 17 µM 1.42797366219337 0.200921698634529 no 760 0.0766497197445502 152 1714895 YML126C ERG13 SGTC_544 k015-0020 52.4 µM 1.42257315381575 0.201795744530882 no 761 0.0774299655057558 119 3008304 SGTC_2080 5212524 12.4 µM 1.42217818195425 0.201859758020426 no 762 0.0774872654544783 112 260183 SGTC_1791 st048313 56.1 µM 1.41768204385698 0.202589308238641 no 763 0.0781418073970401 80 1204976 SGTC_535 2293-4129 48.2 µM 1.41687565388538 0.202720320786012 no 764 0.0782596428621101 129 396118 YIL048W NEO1 SGTC_873 0591-4978 488 µM 1.41350894313474 0.203267850155602 no 765 0.0787530668536429 113 3305145 SGTC_2191 5911152 200 µM 1.41231472355742 0.203462278368397 no 766 0.0789286565107645 97 2875902 SGTC_2651 TUB2.036 5 µM 1.41192563770347 0.203525648517295 no 767 0.0789859289658606 125 15992207 YFL037W TUB2 SGTC_2763 lisinopril 49.32 µM 1.40982933523696 0.203867274404239 no 768 0.079295041175457 96 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3048 9093155 49.47 µM 1.40979717487423 0.203872518108127 no 769 0.0792997905336081 92 25236002 SGTC_2785 7756463 72.73 µM 1.40796849401993 0.20417081427604 no 770 0.0795701997220985 149 2201551 SGTC_1481 3346-2004 36 µM 1.4056835224897 0.204543906110869 no 771 0.0799090610003334 127 2770522 SGTC_1962 st076595 64.5 µM 1.40499699717296 0.204656081679791 no 772 0.0800110856008264 136 279619 SGTC_2142 5622915 118.518 µM 1.40398965935482 0.204820742997174 no 773 0.0801609644146418 75 5322196 SGTC_367 0335-0881 7.1 µM 1.40354084078839 0.204894133081141 no 774 0.0802278111026494 129 23828853 SGTC_1106 tegaserod maleate 11.7 µM 1.400803933254 0.205342006044894 no 775 0.0806363560717695 118 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3021 9087658 49.47 µM 1.40080125153304 0.205342445171994 no 776 0.0806367571480096 76 25237042 SGTC_3006 9075424 71.4286 µM 1.40063975804197 0.205368890475808 no 777 0.0806609127746579 110 7465181 SGTC_1534 6-azauridine 81.6 µM 1.38658535412338 0.207678103699609 no 778 0.0827841184029553 131 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_148 3253-0744 288.01 µM 1.38508465936078 0.207925579009142 no 779 0.0830132910588056 103 6893655 SGTC_2414 st077232 92.9 µM 1.38434593528364 0.208047463823369 no 780 0.0831262774905303 89 729801 SGTC_3227 9130768 49.47 µM 1.38284059466818 0.208295966027981 no 781 0.0833568743216433 93 17720899 SGTC_2925 9010536 32.5 µM 1.38279408578385 0.208303646520011 no 782 0.0833640064730134 87 2994177 SGTC_2826 7992541 19.48 µM 1.37440461497887 0.209691817705011 no 783 0.0846580521147545 119 2985066 SGTC_1788 fluconazole 20 µM 1.37379548067506 0.209792820030847 no 784 0.0847525922811022 118 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_400 oxethazaine 37.5 µM 1.37135170385029 0.210198317192866 no 785 0.0851326725841591 116 4621 A local anesthetic. SGTC_733 4069-0007 56.1 µM 1.37035174414599 0.210364373655446 no 786 0.0852885639296477 122 5717425 YNL287W SEC21 SGTC_3156 9099931 49.47 µM 1.36397525407316 0.211425083769743 no 787 0.0862876770463976 110 18111053 SGTC_1540 guanosine 70.6 µM 1.35895698069062 0.212262056780185 no 788 0.0870801105331899 90 6802 Guanosine is a purine nucleoside SGTC_305 1682-2595 20.8 µM 1.3584698246212 0.212343410129251 no 789 0.0871573256277038 124 226033 SGTC_2312 7706453 155.7 µM 1.35686228349221 0.21261199307441 no 790 0.0874124864550678 124 976098 SGTC_19 0279-0214 38.434 µM 1.35263559908728 0.213319120169779 no 791 0.0880860368898811 123 3566274 YBR002C RER2 SGTC_71 0417-1750 47.813 µM 1.33991334233671 0.215455819529779 no 792 0.090136759923587 110 6811472 SGTC_102 gallobenzophenone 83.616 µM 1.33880760034723 0.215642113153601 no 793 0.0903166579451461 121 70837 SGTC_1053 3366-3204 134 µM 1.33828474989004 0.215730234665927 no 794 0.0904018155772863 128 3632071 YPR165W RHO1 SGTC_422 cantharidin 155 µM 1.3382828231928 0.215730559431172 no 795 0.0904021294922908 117 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_282 k297-0036 65.7 µM 1.33441818455217 0.216382555465301 no 796 0.0910334218518347 121 5061378 SGTC_2403 6032726 181.2 µM 1.33257984393799 0.216693098367986 no 797 0.0913348616643621 102 2881040 SGTC_1301 naphtanilide LB 4.81 µM 1.33253474981269 0.216700719160431 no 798 0.0913422652095933 135 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_736 0958-0254 92.6 µM 1.33191618899139 0.216805270010134 no 799 0.0914438653230937 131 6812352 SGTC_1456 k015-0012 13 µM 1.32876034520518 0.217339133181495 no 800 0.0919635244217739 145 2989616 SGTC_391 gliotoxin 8.33 µM 1.32684769778111 0.217663058242329 no 801 0.0922795342991354 126 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2476 5806916 10.51 µM 1.3265333650453 0.217716320125201 no 802 0.0923315455303357 109 2870194 SGTC_594 1487-1584 10.8 µM 1.32246739789578 0.21840595235974 no 803 0.0930062793493995 134 5013332 SGTC_3036 9090181 49.47 µM 1.32163813932428 0.218546757942911 no 804 0.0931443384337443 116 25236586 SGTC_2869 9037858 32.47 µM 1.32162281910939 0.218549359760431 no 805 0.0931468904432642 112 27187042 SGTC_1420 4'-methoxyflavone 42 µM 1.32158757843271 0.218555344718724 no 806 0.0931527609580002 103 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_313 3474-0040 5.03 µM 1.32102317280879 0.218651211130609 no 807 0.0932468188733433 144 1043375 YIL048W NEO1 SGTC_2708 st078559 56 µM 1.3199507028735 0.218833440851807 no 808 0.0934257387776955 84 17250902 SGTC_1859 st055998 20 µM 1.3170575562167 0.219325468141369 no 809 0.0939096663017867 116 676301 SGTC_442 cape 100 µM 1.31441812871845 0.2197749003677 no 810 0.0943527665152174 109 5281787 SGTC_3173 9105693 49.47 µM 1.31270459091821 0.220066958230132 no 811 0.0946412550181207 118 17096658 SGTC_2272 7805186 180 µM 1.31161952047163 0.220252014280116 no 812 0.0948242716555457 130 2956062 YPR165W RHO1 SGTC_2709 st078560 56 µM 1.30846395505626 0.220790694848003 no 813 0.095357996299533 143 17250903 SGTC_2893 9048488 25.97 µM 1.30803031528429 0.220864779584502 no 814 0.0954315135706628 142 6467338 SGTC_1437 4092-1038 11.6 µM 1.30743678500301 0.220966203716881 no 815 0.0955322055545257 137 3977136 SGTC_454 lyso-paf C-16 6.67 µM 1.30699684408277 0.221041399265902 no 816 0.0956068916560901 121 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_108 0509-0257 621.132 µM 1.30430588785445 0.221501661300647 no 817 0.0960646543065442 144 536624 SGTC_2786 7743617 45.45 µM 1.29952292407778 0.222321091769531 no 818 0.0968822657692699 110 583674 SGTC_2757 clomiphene 4.22 µM 1.2967461447461 0.2227976095834 no 819 0.0973592732022355 160 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1363 1636-0063 10.4 µM 1.29637888026457 0.222860678691424 no 820 0.0974224923067969 146 6072185 SGTC_480 am 92016 50 µM 1.29600709591788 0.222924534339935 no 821 0.0974865201034963 155 2129 K+ channel blocker. SGTC_2996 9066192 71.4286 µM 1.29516805573088 0.223068681594746 no 822 0.0976311309774871 122 6472854 SGTC_301 4119-0100 24.5 µM 1.29335316465448 0.223380661711468 no 823 0.0979444704024562 122 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1046 2001-0062 216 µM 1.29290864709261 0.223457112198193 no 824 0.0980213282258718 134 739778 SGTC_1196 1588-0294 184 µM 1.2917823594272 0.223650883743585 no 825 0.0982162630571013 132 6144269 SGTC_589 1227-0070 34.1 µM 1.28995954167653 0.22396469178587 no 826 0.0985323528889012 120 2841384 SGTC_2083 5306046 65.942 µM 1.28472364253554 0.224867470484791 no 827 0.0994444367095032 124 539837 SGTC_2031 5180455 200 µM 1.28400946038713 0.224990770137874 no 828 0.0995693226445373 129 29949 SGTC_1016 4226-1401 38 µM 1.28354271763532 0.225071371427163 no 829 0.0996510018300851 136 2901613 SGTC_3325 9138760 55.175 µM 1.2832275497196 0.22512580667847 no 830 0.0997061833620467 109 43844959 SGTC_1478 0453-0656 35.7 µM 1.27674564276136 0.22624700322377 no 831 0.100846030873761 139 5258496 SGTC_744 1594-0068 283 µM 1.27351718271572 0.226806615294305 no 832 0.101417289598545 136 668392 SGTC_2880 9042983 58.44 µM 1.26563921761989 0.228175431808982 no 833 0.102821139342236 152 6464714 SGTC_1063 disulfiram 1.84 µM 1.26374693401312 0.22850491137155 no 834 0.103160436706795 132 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1632 st005650 90 µM 1.25958161401472 0.229231107007106 no 835 0.10391016578068 127 2759605 SGTC_587 k089-0003 57 µM 1.2578471796963 0.229533875211131 no 836 0.104223514651025 103 9659696 SGTC_2359 9039622 200 µM 1.25122491561138 0.230691936629303 no 837 0.105426215200519 126 6463596 SGTC_1646 st011709 75.6 µM 1.25070508078319 0.230782980156975 no 838 0.105521048051904 142 5757843 SGTC_1381 2324-0066 62.1 µM 1.25006768199884 0.230894641142365 no 839 0.105637412134595 144 10885928 SGTC_2961 9083290 32.55 µM 1.2499055722383 0.230923044714122 no 840 0.105667021829059 130 17741490 SGTC_2018 5133068 143 µM 1.24909806383508 0.23106455891644 no 841 0.105814604359382 135 785362 SGTC_2723 salbutamol 83.58 µM 1.24876058790728 0.23112371522325 no 842 0.10587632654395 117 9884233 β2-adrenoceptor agonist SGTC_2313 7726885 200 µM 1.2475075982892 0.231343426261373 no 843 0.106105717966988 134 726423 SGTC_3161 9100388 49.47 µM 1.24632353562273 0.231551158005167 no 844 0.106322820343934 137 25236368 SGTC_952 1185-0122 232 µM 1.24589520729839 0.23162632945242 no 845 0.106401434925839 118 678600 SGTC_2049 5262831 67.185 µM 1.243942159347 0.231969260914785 no 846 0.106760425730139 123 763417 SGTC_2653 dihydrofissinolide 100 µM 1.24331843614711 0.23207883865355 no 847 0.106875256559578 125 6857746 SGTC_3123 9126162 49.47 µM 1.2419270317473 0.232323388952867 no 848 0.107131742732613 117 25239884 SGTC_1399 3562-5772 25 µM 1.23984848335549 0.232688977124753 no 849 0.10751572078321 129 23847490 SGTC_362 0310-0100 9.03 µM 1.23917632124237 0.232807269611533 no 850 0.107640103785118 110 790235 SGTC_2008 4012253 172 µM 1.23737176446228 0.233125015217985 no 851 0.107974548144469 145 603940 SGTC_2251 lansoprazole 556 µM 1.23308985821898 0.233879934059344 no 852 0.108771120417261 121 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2467 5474540 200 µM 1.23277807082757 0.233934956400798 no 853 0.108829287517458 138 5413519 SGTC_2592 piperlongumine 83.33 µM 1.22686427964156 0.234979943222902 no 854 0.109936803068502 143 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_828 2074-0507 139 µM 1.22633516670883 0.235073564798556 no 855 0.110036286381818 136 X828 SGTC_3229 9132204 49.47 µM 1.22571369818793 0.235183554138533 no 856 0.110153216769409 107 17682924 SGTC_1842 st055362 61.2 µM 1.22487768060331 0.235331559826975 no 857 0.110310655499181 129 676032 SGTC_3027 9089541 49.47 µM 1.22349986295044 0.235575596100279 no 858 0.110570477958035 145 9943819 SGTC_1608 st001473 40.5 µM 1.22219064513829 0.235807611403261 no 859 0.110817770345734 175 7292267 SGTC_973 1325-0077 65.9 µM 1.2170484358152 0.236720114983663 no 860 0.11179289390226 128 2835149 SGTC_1781 st038725 66.3 µM 1.2162931151866 0.236854312753002 no 861 0.111936641637251 163 4270275 YIL048W NEO1 SGTC_1250 0485-0349 40.2 µM 1.21462795172172 0.237150309944524 no 862 0.112254011528325 138 6842794 YDL195W SEC31 SGTC_1878 temozolomide 1 mM 1.21110156870584 0.237777825361082 no 863 0.112928240133894 138 5394 DNA alkylating agent. SGTC_1002 4049-0206 172 µM 1.20764837922265 0.238393197624054 no 864 0.113591270873577 144 4662749 SGTC_2446 5162541 200 µM 1.2052847000377 0.238814917033986 no 865 0.114046706999315 131 1549321 SGTC_2289 7946404 165.07 µM 1.20528049190322 0.238815668198411 no 866 0.114047518985325 159 1246120 YPR165W RHO1 SGTC_2948 9070189 9.45 µM 1.20511392220617 0.238845402418927 no 867 0.114079662963724 115 6473636 YDL196W YDL196W SGTC_2163 5671233 125 µM 1.20144553662091 0.239500756010696 no 868 0.114789210584807 151 701023 SGTC_1783 st039459 87.517 µM 1.20140174959159 0.239508584446884 no 869 0.114797698893094 160 729761 SGTC_703 3875-0075 71.8 µM 1.20100865611416 0.239578869670855 no 870 0.114873921792876 159 2850814 SGTC_2315 7733312 200 µM 1.19969880782882 0.239813152156937 no 871 0.115128168111164 142 726316 SGTC_90 0870-0863 4.608 µM 1.19798031118646 0.240120715896589 no 872 0.115462341009372 168 1738164 SGTC_2 0422-0095 29 µM 1.19782134258452 0.240149177774932 no 873 0.115493288285373 130 6790840 SGTC_1815 st051655 58.2 µM 1.19708251525583 0.240281482199649 no 874 0.115637197141255 157 5984156 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.1960382588365 0.240468548609538 no 875 0.115840814686728 161 5024745 SGTC_491 tetrandrine 80.3 µM 1.1947988048278 0.2406906852993 no 876 0.116082823708909 129 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3324 9138759 60.749 µM 1.19334381625203 0.24095159284111 no 877 0.116367374477152 129 45595710 SGTC_1512 0259-0544 12.2 µM 1.19239410003519 0.241121978232058 no 878 0.116553376310037 149 18476 SGTC_1076 itraconazole 331 nM 1.18781744674935 0.24194397782583 no 879 0.117452669617198 148 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_42 0133-0086 60.653 µM 1.17928545074778 0.243480435007576 no 880 0.119142264859233 181 162923 Model of phenazepam hydroxylation. SGTC_2409 alverine citrate 63.97 µM 1.17822872642401 0.24367109799245 no 881 0.119352716625871 116 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2909 7941780 10.49 µM 1.17579062747878 0.244111307458378 no 882 0.119839276305862 146 1243215 SGTC_1984 st072354 53.1 µM 1.17523564274105 0.24421157227989 no 883 0.119950227068168 145 5762938 SGTC_440 fluspirilene 35.1 µM 1.17306802693875 0.244603391366498 no 884 0.120384263471481 148 3396 An atypical antipsychotic. SGTC_2565 isoliquiritigenin 100 µM 1.17093217780417 0.244989799218563 no 885 0.120813019897229 137 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2381 9035592 200 µM 1.16920133295205 0.245303176329595 no 886 0.121161262137015 135 4749657 SGTC_1964 st076914 61 µM 1.16564032935859 0.245948588887793 no 887 0.121879947495761 180 24208661 SGTC_2760 etidronate 98.04 µM 1.16173856246663 0.246656807805303 no 888 0.122670838297179 142 3305 A chelator and antioxidant. SGTC_1963 st076565 50.3 µM 1.16125605056952 0.246744465500367 no 889 0.122768893346758 167 4914280 SGTC_2566 crystal violet carbinol 226 nM 1.16052639248864 0.246877053795826 no 890 0.122917277316227 185 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1022 4477-0945 21.3 µM 1.15730836219606 0.247462266132851 no 891 0.123573199140857 130 4648966 SGTC_2287 7945887 168.79 µM 1.15632813200861 0.24764067229301 no 892 0.123773482804751 156 1245853 SGTC_1155 4088-0394 48.2 µM 1.15096233565001 0.248618486660476 no 893 0.124873865475665 152 2326248 SGTC_2241 6772625 37.8075 µM 1.15021199260189 0.248755386132587 no 894 0.125028283993214 154 2285411 SGTC_2915 7971052 15.16 µM 1.15002820896054 0.248788923425464 no 895 0.1250661264833 115 5741558 SGTC_1505 k297-0037 20.6 µM 1.14971821428395 0.248845497474217 no 896 0.125129974938738 136 4089396 SGTC_2614 arthonioic acid 13.39 µM 1.14548415597101 0.249618898479883 no 897 0.126004327504526 137 6710684 SGTC_2817 7995342 71.43 µM 1.14505625494118 0.249697130660079 no 898 0.126092927470852 137 18879975 SGTC_1361 1608-0041 5.61 µM 1.14427237671546 0.249840479117353 no 899 0.126255347696269 149 X1361 SGTC_2770 toltrazuril 17.5 µM 1.1434020957624 0.249999679274407 no 900 0.126435841375508 136 68591 Kills coccidiodes. SGTC_2721 ifenprodil 61.44 µM 1.14013515160844 0.250597780086654 no 901 0.127114999598714 148 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_771 0250-0039 27.3 µM 1.13819586335679 0.250953176463695 no 902 0.127519352813847 165 3005115 SGTC_1893 st059353 36.1 µM 1.13693393188146 0.251184582774104 no 903 0.127782952940029 168 3112488 SGTC_743 1275-0778 158 µM 1.13419677287265 0.251686896095581 no 904 0.12835600870084 183 2849257 YMR203W TOM40 SGTC_1986 st071812 45 µM 1.13330931887026 0.251849872193083 no 905 0.128542189861802 138 11838594 SGTC_712 r015-0009 80.6 µM 1.12971472653634 0.252510568908644 no 906 0.129298224924702 146 6813872 YLR060W FRS1 SGTC_1768 st044301 37.178 µM 1.12954793964911 0.252541246987681 no 907 0.12933337915166 197 3931349 SGTC_210 3551-0445 56.827 µM 1.12914432871277 0.252615493611877 no 908 0.12941847697932 145 2865180 YOR207C RET1 SGTC_1678 st019265 80.2 µM 1.12906676450962 0.252629763323858 no 909 0.129434835155105 138 5367020 SGTC_1809 st050081 57.6 µM 1.12880784809287 0.252677400003863 no 910 0.129489450617742 161 5036894 SGTC_550 4123-0385 25.7 µM 1.12878338563123 0.25268190096907 no 911 0.129494611520199 153 5731123 SGTC_1299 1079-1439 3.74 µM 1.12717812625611 0.252977352587125 no 912 0.129833588374988 163 323161 SGTC_1228 0124-0032 52.5 µM 1.12643658727285 0.253113895871715 no 913 0.129990383779113 135 X1228 SGTC_2605 digitonin 300 nM 1.12513132306108 0.253354334845365 no 914 0.130266694902452 181 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1805 st050013 60.3 µM 1.12509404327231 0.253361203811276 no 915 0.130274592617755 157 4037144 SGTC_44 0929-0055 61.211 µM 1.12319590748993 0.253711073061692 no 916 0.130677150164482 171 1379590 SGTC_3183 9108214 49.47 µM 1.12214985510732 0.253903992494682 no 917 0.13089936463564 99 4974831 SGTC_1375 2910-0797 186 µM 1.1203955984484 0.25422769606735 no 918 0.131272609891462 140 742508 SGTC_1340 1486-1359 257 µM 1.1157631517841 0.255083535687441 no 919 0.132261765235001 166 4309068 SGTC_822 1487-0950 154 µM 1.11372519975731 0.25546052193697 no 920 0.132698547531768 157 1958375 SGTC_3297 9117502 71.43 µM 1.11367054226192 0.255470636645251 no 921 0.132710275616274 118 7453720 SGTC_1161 k007-0610 110 µM 1.11298811587832 0.255596941490937 no 922 0.132856766768511 193 5843850 SGTC_1871 st057448 67.3 µM 1.11250617494731 0.255686159732498 no 923 0.132960288330672 165 691747 SGTC_598 3937-0236 20.2 µM 1.11237133439372 0.255711124700747 no 924 0.132989262203051 179 1379313 SGTC_738 1315-0003 72.4 µM 1.10743561705546 0.256625820129265 no 925 0.134052816978346 171 6251474 SGTC_2833 9001315 45.46 µM 1.10121354803217 0.257781327603644 no 926 0.13540186330883 155 2989378 SGTC_2819 7996655 46.38 µM 1.10048249985585 0.257917268450377 no 927 0.135560975196036 130 6456960 SGTC_2095 5432005 200 µM 1.09632407712305 0.25869124794927 no 928 0.136468488162438 162 783734 SGTC_1008 4106-0037 6 µM 1.09322984396176 0.259267936114651 no 929 0.137146448398129 182 2905394 SGTC_3352 9151559 45.5865 µM 1.09199251961687 0.259498728436824 no 930 0.13741819456559 153 17159339 SGTC_76 0433-0009 400.328 µM 1.08758069590775 0.26032250803798 no 931 0.138390128288838 154 2841569 SGTC_2432 5630864 12.22 µM 1.08527402867561 0.260753746697329 no 932 0.138900152554899 160 5714970 SGTC_1461 k072-0203 53.8 µM 1.08369223615124 0.261049680075708 no 933 0.139250639565077 148 5418714 SGTC_1178 0988-0033 191 µM 1.08260824860862 0.26125258009694 no 934 0.139491172239662 156 5392207 SGTC_1030 k029-0042 36.7 µM 1.08038224870168 0.261669495075001 no 935 0.139985998645319 154 6080581 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.07986380923601 0.261766644333855 no 936 0.140101415668956 174 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1575 cyproterone acetate 48 µM 1.07594832949384 0.262500954792026 no 937 0.140975182855694 178 9880 An androgen receptor antagonist and liver toxin. SGTC_3172 9105863 49.47 µM 1.07573558896378 0.262540882407492 no 938 0.141022763058194 159 2348785 SGTC_1677 st019204 53.9 µM 1.07292860609882 0.263067994118609 no 939 0.141651575018307 144 3945625 SGTC_2461 5755302 26.15 µM 1.07147483717156 0.263341203804539 no 940 0.141977989482816 177 2788904 SGTC_111 0083-0039 52.457 µM 1.06978708796597 0.263658567508142 no 941 0.142357577782828 139 759313 SGTC_2812 7970281 58.44 µM 1.06831674760225 0.263935208679691 no 942 0.142688828211407 173 2233435 SGTC_2067 5224629 34.075 µM 1.06780751179227 0.264031054713246 no 943 0.142803674464247 164 2835000 SGTC_1108 betulinic acid 729.144 nM 1.06678999646146 0.264222619902031 no 944 0.143033338411563 153 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_385 1494-0393 12.4 µM 1.06435528568277 0.264681284246804 no 945 0.143583890859718 170 3090647 SGTC_3087 9117406 49.47 µM 1.06429993807152 0.264691715642569 no 946 0.143596423022161 143 42546093 SGTC_2126 5251174 33.877 µM 1.05482959386985 0.266479669872113 no 947 0.145751633593401 163 790722 SGTC_1789 tunicamycin 25 nM 1.0541310145899 0.266611799722743 no 948 0.145911469193179 177 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2290 7904846 200 µM 1.04887586650528 0.267606823400386 no 949 0.147117627106325 165 2962154 SGTC_2055 5235184 200 µM 1.04699049620058 0.267964260142494 no 950 0.14755198074317 169 2836034 SGTC_113 0099-0221 2.5 µM 1.04591569862309 0.268168132497623 no 951 0.14779997784295 167 89219 SGTC_1732 st034308 51.822 µM 1.03755474143006 0.269756736462816 no 952 0.149738698883039 173 830119 SGTC_1721 st082152 9.2685 µM 1.03437603302106 0.2703619335284 no 953 0.150480202165563 169 5296051 SGTC_2738 aclarubicin 5.55 µM 1.03256584417328 0.270706879995885 no 954 0.150903559608181 133 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_912 3474-0017 2.18 µM 1.0295836250417 0.271275645358632 no 955 0.151602752678488 177 3360550 SGTC_213 1246-0773 967 nM 1.02936415122163 0.271317526669018 no 956 0.151654294120246 155 6251622 SGTC_2598 perillyl alcohol 100 µM 1.02694688844978 0.271779016334071 no 957 0.152222736917243 156 10819 An apoptosis inducer. SGTC_2853 9015042 58.44 µM 1.02579081152916 0.271999865782896 no 958 0.152495099049392 155 6457456 SGTC_109 0132-0036 33.701 µM 1.02554089080298 0.272047620750052 no 959 0.152554020783346 158 67274 A color developer. SGTC_335 4077-0256 27.6 µM 1.02183769465772 0.272755717353084 no 960 0.153428862661158 199 3121989 SGTC_3063 1327-0034 4 µM 1.02175119437164 0.272772268193432 no 961 0.153449337100456 186 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2181 6316240 54.2555 µM 1.02125342592997 0.272867520173565 no 962 0.153567193033806 161 12779990 SGTC_383 2324-0395 7.37 µM 1.02020805225929 0.273067614490048 no 963 0.153814899769214 164 3146421 SGTC_1568 digitonin 820 nM 1.0199657947102 0.273113995232956 no 964 0.153872341681371 201 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2431 5490079 200 µM 1.01925542554497 0.273250019483414 no 965 0.154040859813896 200 5722345 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.01810093614669 0.273471157170697 no 966 0.154314995255484 178 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2732 terfenadine 20 µM 1.01789155785582 0.273511272208155 no 967 0.154364747018846 210 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1562 morin hydrate 59.1 µM 1.0176992265625 0.273548123757325 no 968 0.154410457476655 166 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_923 1900-2434 73.3 µM 1.01279098393626 0.27448939601507 no 969 0.155580004069527 204 5910570 SGTC_3066 9117245 49.47 µM 1.00852375763594 0.275309034823127 no 970 0.156601544138661 168 17176980 SGTC_868 0527-0199 213 µM 1.00798424599636 0.27541274866392 no 971 0.156731012658316 173 2849450 SGTC_2875 9039966 71.43 µM 1.00736471440966 0.275531868967376 no 972 0.156879770717924 169 6463691 SGTC_137 0438-0332 85.389 µM 1.00412808118512 0.27615460360462 no 973 0.157658440848492 208 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1943 st076331 65.2 µM 1.00224124435982 0.276517953225689 no 974 0.15811354614018 181 24208415 SGTC_697 0508-1955 564 µM 0.998894489016358 0.277163016504368 no 975 0.158922903087912 167 6243113 SGTC_1650 st011916 45.8 µM 0.994737802435521 0.277965211949188 no 976 0.159931901845398 193 242528 SGTC_3086 9117350 49.47 µM 0.990107849349927 0.278860074499897 no 977 0.161060703577456 151 2679265 SGTC_443 clozapine 122 µM 0.988755025440092 0.279121808375257 no 978 0.161391506782642 183 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1140 3229-1848 2.98 µM 0.988407850335629 0.279188996374564 no 979 0.161476472182531 182 2849525 SGTC_3103 9120822 49.47 µM 0.984269985795634 0.27999039243075 no 980 0.162491391439917 214 17141819 SGTC_3296 9122258 64.045 µM 0.978824734393466 0.281046691590671 no 981 0.163833293074296 171 4730474 SGTC_2943 9068529 45.32 µM 0.978685187206256 0.281073786988027 no 982 0.163867776666884 229 3270634 SGTC_2104 5389443 200 µM 0.978087392328198 0.281189873043626 no 983 0.164015551435656 188 2244536 SGTC_399 oxolinic acid 75 µM 0.973928911271843 0.281998050447763 no 984 0.165045918748785 192 4628 A DNA gyrase inhibitor. SGTC_2214 7179297 48.276 µM 0.97276822177019 0.282223823468421 no 985 0.165334254975587 184 769744 SGTC_1647 st011722 22.4 µM 0.970495187926747 0.282666217424746 no 986 0.165899861179296 184 2854783 SGTC_1644 st010134 20.9 µM 0.969429963789327 0.282873653519145 no 987 0.1661653541271 205 3818134 SGTC_3181 9108277 49.47 µM 0.963655480841195 0.283999416180462 no 988 0.167609340607697 192 17097298 SGTC_384 k007-0144 5.16 µM 0.962729052979481 0.284180227005109 no 989 0.167841756399659 201 6824886 SGTC_1997 st073024 93.8 µM 0.959993672603748 0.28471441185431 no 990 0.168529199725134 189 686268 SGTC_2090 5301565 104.445 µM 0.958567076494696 0.284993197888573 no 991 0.168888442561397 197 2056344 SGTC_1797 st048695 56.8 µM 0.95848497719853 0.285009245729405 no 992 0.168909131616847 213 592262 YIL048W NEO1 SGTC_2054 5233173 129 µM 0.957923772773113 0.285118955154546 no 993 0.16905059895822 134 6889 SGTC_1145 3546-0597 10.2 µM 0.957902593372416 0.28512309589359 no 994 0.169055939310804 193 875334 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.956985690306903 0.285302385114622 no 995 0.169287238850671 189 4330530 SGTC_1674 st016616 23.6 µM 0.956157124234548 0.285464447293354 no 996 0.169496428994786 186 625830 SGTC_1342 1486-1464 234 µM 0.954736255146204 0.285742462104252 no 997 0.169855545286531 196 3253938 SGTC_1191 1487-1166 10.6 µM 0.950980966484962 0.2864778612483 no 998 0.170807019020677 186 3955771 SGTC_1421 4029-0249 71.4 µM 0.950532048533255 0.28656583302624 no 999 0.170920988721764 212 2894095 SGTC_2848 9016370 25.97 µM 0.949122565921428 0.286842124187822 no 1000 0.17127913928869 182 7894410 SGTC_1091 telmisartan 47.6 µM 0.948987192868863 0.286868667077613 no 1001 0.171313562917217 202 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1810 st050138 53 µM 0.947871624078184 0.287087443387294 no 1002 0.171597406116404 230 3444541 SGTC_1286 0929-0070 131 µM 0.946817219236988 0.287294297317109 no 1003 0.17186596293074 199 1420408 SGTC_1276 0871-0068 94.2 µM 0.945893944960451 0.287475483849094 no 1004 0.172101341080141 215 3414906 SGTC_1879 gemcitabine 100 µM 0.945476563326214 0.287557409994118 no 1005 0.172207815222334 199 60750 A nucleoside analog which inhibits DNA replication. SGTC_2379 9035213 200 µM 0.943577250386858 0.287930357742216 no 1006 0.17269286106168 209 646551 SGTC_3204 9114183 49.47 µM 0.942450917349336 0.288151631524707 no 1007 0.172980914558338 180 17027248 SGTC_3080 9117754 49.47 µM 0.94090248678853 0.288455959383464 no 1008 0.173377416566349 214 9550191 SGTC_298 1391-0729 10 µM 0.937635738986041 0.289098501000182 no 1009 0.174215819149318 204 3237558 SGTC_1765 st044815 90.4 µM 0.937117309944598 0.289200533454675 no 1010 0.17434910915602 215 645695 SGTC_1969 st069479 40.1 µM 0.93583899463703 0.289452192071811 no 1011 0.174678045456878 200 3895485 SGTC_659 k018-0002 107 µM 0.934550471729362 0.289705964282135 no 1012 0.175010006848587 199 6797879 YHR007C ERG11 SGTC_759 3486-0358 89.3 µM 0.931150501654353 0.290376082885464 no 1013 0.175887859097556 219 875103 SGTC_1115 galangin 695.678 nM 0.930405227850465 0.290523069877701 no 1014 0.17608065640563 222 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2150 5556613 200 µM 0.928076610813741 0.290982556733442 no 1015 0.176683915582482 199 743190 SGTC_883 0850-0245 24.6 µM 0.92461709972863 0.291665819860261 no 1016 0.177582557552087 219 6823229 YPR165W RHO1 SGTC_3279 9140807 49.47 µM 0.92438352026316 0.291711979397661 no 1017 0.177643335887334 207 45595718 SGTC_905 2-aminofluorene 215 µM 0.922847294666606 0.292015650225761 no 1018 0.178043395079899 203 1539 An established DNA mutagen. YPR165W RHO1 SGTC_310 1273-0058 1.06 µM 0.921716107568201 0.292239349786118 no 1019 0.178338338216528 171 2734232 SGTC_2202 7226349 200 µM 0.921096195609791 0.292361975187819 no 1020 0.178500103154554 175 844334 SGTC_1867 st057372 64 µM 0.91747251741441 0.293079256822001 no 1021 0.179447543886542 182 688837 SGTC_2707 st078556 66.6 µM 0.915621239986228 0.293446018927209 no 1022 0.179932793553168 181 17250899 SGTC_3065 9113888 49.47 µM 0.908293019291272 0.294899916938852 no 1023 0.181861714845094 199 16648368 SGTC_2023 5144124 124 µM 0.904280536884166 0.295697385883155 no 1024 0.182923332239314 208 2830192 SGTC_1690 st023502 41.2 µM 0.903867375211635 0.295779556783184 no 1025 0.183032865207336 203 24207482 SGTC_1515 3460-0031 42.1 µM 0.903584830633069 0.29583575618187 no 1026 0.183107793935457 207 2876596 SGTC_3140 9094243 49.47 µM 0.902856836070914 0.295980580197959 no 1027 0.18330094084804 239 19291112 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.901229584918323 0.296304415970521 no 1028 0.183733131982034 220 688788 SGTC_962 1254-0300 21.5 µM 0.900901144208999 0.296369797954844 no 1029 0.183820441405705 186 7340576 SGTC_421 streptovitacin 30 mM 0.89596669754622 0.297352882728426 no 1030 0.185135274926703 202 91467 include heat shock SGTC_2492 derrusnin 100 µM 0.895191980025809 0.297507364118248 no 1031 0.185342235593334 229 1715307 Part of coumarin class of compounds. SGTC_2753 fluvastatin 17.09 µM 0.894444953945996 0.297656358430713 no 1032 0.185541934649668 207 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_3049 9092223 49.47 µM 0.892102412429044 0.298123798868687 no 1033 0.186169020981429 194 8623917 SGTC_2050 5263056 171 µM 0.891060469033342 0.298331819968763 no 1034 0.186448365435543 211 763468 YGL055W OLE1 SGTC_631 k072-0230 41.5 µM 0.89105147211241 0.298333616466703 no 1035 0.186450778635128 203 5773147 SGTC_3162 9099653 49.47 µM 0.889746227693175 0.2985942987881 no 1036 0.186801082860676 181 25237511 SGTC_2027 5150920 200 µM 0.887246861783479 0.299093758933056 no 1037 0.187473003810588 206 786715 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.886000492556697 0.299342968447631 no 1038 0.18780863089159 192 803109 SGTC_2258 7960471 200 µM 0.884237779684037 0.299695580730318 no 1039 0.188283934037507 202 2974708 SGTC_833 3852-0053 558 µM 0.882312866336531 0.300080854287901 no 1040 0.188803820276339 221 3123681 SGTC_1210 3013-0140 750 nM 0.88178838773704 0.300185868090382 no 1041 0.188945626206694 202 905973 SGTC_3212 9128307 49.47 µM 0.875040690000818 0.301538406209565 no 1042 0.19077588313147 175 27243542 SGTC_2556 citropten 84.59 µM 0.87390830406864 0.301765655025918 no 1043 0.191084096026366 199 2775 A potential DNA crosslinker. SGTC_692 k241-0027 77.8 µM 0.873868689931653 0.301773606240753 no 1044 0.191094883730327 209 3600480 SGTC_1495 4469-0029 237 µM 0.873866850524552 0.301773975442578 no 1045 0.191095384645914 203 793680 SGTC_577 r071-0003 38.6 µM 0.869721653064197 0.302606505775696 no 1046 0.192226268062537 244 4568517 YMR134W ERG29 SGTC_725 1497-0963 19 µM 0.869460419842349 0.30265900687603 no 1047 0.192297673981131 219 3549977 SGTC_2026 5148700 152 µM 0.867003149142836 0.303153054146535 no 1048 0.19297014211806 216 79838 SGTC_578 3460-0051 92 µM 0.865982119233614 0.30335844362339 no 1049 0.193249983745036 251 2876744 SGTC_1386 3228-0095 33.8 µM 0.865474029677698 0.303460673637415 no 1050 0.193389332056673 207 870181 SGTC_2731 amoxapine 43.43 µM 0.864924721589041 0.303571214324215 no 1051 0.19354005388622 254 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1531 st059297 52.4 µM 0.864837541724812 0.303588759724216 no 1052 0.193563981308339 222 7566702 SGTC_2473 5854593 8.94 µM 0.864327268267647 0.303691463984606 no 1053 0.193704067357278 218 2872951 SGTC_2449 5812982 45.77 µM 0.862394132361966 0.304080692591141 no 1054 0.194235334167563 205 776185 SGTC_2862 9027634 71.43 µM 0.862049008351608 0.304150205210578 no 1055 0.194330274845149 215 5012562 SGTC_2656 pseudo-anisatin 100 µM 0.861157322955453 0.304329835416028 no 1056 0.194575700685639 245 6708809 A neurotoxin. SGTC_2293 7624732 200 µM 0.858250382283602 0.304915766934662 no 1057 0.195377110551939 209 894453 SGTC_1930 st074634 34.3 µM 0.854081007625931 0.305757032068416 no 1058 0.196530053186884 219 684253 YOR116C RPO31 SGTC_1660 st012960 28.1 µM 0.850696287870008 0.306440730381756 no 1059 0.197469042900759 211 24207266 SGTC_862 0452-0056 10.2 µM 0.850451456735603 0.306490211361284 no 1060 0.197537069053853 210 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1581 himbacine 57.9 µM 0.849671945376444 0.306647776036438 no 1061 0.197753750064005 224 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3050 9093513 49.47 µM 0.847332500207357 0.307120868727349 no 1062 0.198404908160772 240 25236664 SGTC_2682 pyrogallin 40.03 µM 0.845488665607706 0.30749396334538 no 1063 0.198919029184666 221 822798 An ATP competetive kinase inhibitor. SGTC_1217 1183-1422 255 µM 0.845431459369057 0.307505542051624 no 1064 0.19893499297523 227 2849664 SGTC_949 1165-0505 146 µM 0.845389179629895 0.307514099714964 no 1065 0.198946791920627 227 6244267 SGTC_2685 mycophenolic acid 18.85 µM 0.843439850299236 0.307908768930877 no 1066 0.199491246294445 216 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_17 0960-0276 49.807 µM 0.837831426895084 0.309045512068946 no 1067 0.201062692885676 231 6821114 SGTC_125 0133-0007 11.75 µM 0.836684757905405 0.30927815043934 no 1068 0.201384894467877 230 26541 SGTC_172 1112-0046 2.638 µM 0.836250570173431 0.309366259233812 no 1069 0.201506977254157 223 2802135 YIL048W NEO1 SGTC_192 3455-0609 60.9 µM 0.834486078804563 0.309724436468791 no 1070 0.202003564435736 212 3769639 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.833901346761512 0.309843172153615 no 1071 0.202168289133741 230 5711223 A potent inhibitor of glutathione S-transferases. SGTC_894 0960-0238 55.9 µM 0.832595856498318 0.310108336579521 no 1072 0.202536348320508 251 6741907 YDL195W SEC31 SGTC_1142 3253-1408 9.78 µM 0.832405197400764 0.310147070538278 no 1073 0.20259013468067 229 256655 SGTC_1851 st056236 18.9 µM 0.829085619107365 0.310821807416831 no 1074 0.203527980338556 218 5393171 SGTC_2704 st078022 71.1 µM 0.827475704825324 0.311149267699594 no 1075 0.203983743467733 221 54697681 SGTC_1290 0986-0249 10.2 µM 0.823542325107628 0.311949954835539 no 1076 0.205099829253449 245 53329 SGTC_2802 7925815 54.55 µM 0.823200938323506 0.312019490255556 no 1077 0.205196867688926 222 1262923 SGTC_2516 gossypol 71.55 µM 0.822437022842822 0.312175112763181 no 1078 0.205414107763666 235 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_59 0330-0160 1.33 µM 0.819622610167306 0.312748745313203 no 1079 0.206215640052879 223 4293482 SGTC_2072 5231554 129 µM 0.817925063485564 0.313094958153123 no 1080 0.20669998894021 251 789545 SGTC_1198 1612-1005 86.7 µM 0.816624164221335 0.31336038676729 no 1081 0.207071620745045 260 6998509 SGTC_1488 4013-0813 75.9 µM 0.816180365651683 0.313450959211779 no 1082 0.207198492392126 221 2910057 SGTC_2028 5153890 36.43 µM 0.814714774459535 0.313750143671853 no 1083 0.207617797170938 242 2830968 YPR165W RHO1 SGTC_3144 9087057 49.47 µM 0.812608641015769 0.314180302366084 no 1084 0.208221237868374 226 17249618 SGTC_2719 novobiocin 32.65 µM 0.810692931835586 0.314571787975652 no 1085 0.208771016702291 248 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_379 3970-0972 5.9 µM 0.808314010349339 0.315058223838494 no 1086 0.209454919608511 239 2898042 YBL034C STU1 SGTC_1362 1611-0397 101 µM 0.806567167615354 0.315415618237186 no 1087 0.209957947971239 235 27816 SGTC_887 0885-0007 9.62 µM 0.806139573663262 0.31550312793707 no 1088 0.210081187841398 244 5719458 SGTC_3033 9090887 49.47 µM 0.80554830642248 0.315624151417087 no 1089 0.210251671139419 230 19325384 SGTC_3290 9121031 71.43 µM 0.804106674272436 0.315919314629423 no 1090 0.210667685167036 233 17014854 SGTC_1944 st076371 56.9 µM 0.803419115393824 0.31606012843846 no 1091 0.210866265065791 246 24208455 SGTC_1414 3917-0015 5.4 µM 0.802909051613236 0.316164608044135 no 1092 0.211013651946088 241 6618702 SGTC_244 nsc-207895 1.295 µM 0.79988876312086 0.316783573544613 no 1093 0.211887624401431 191 42640 SGTC_2435 5706476 10.6 µM 0.797823525765103 0.317207110386986 no 1094 0.212486453516534 217 5725375 SGTC_939 1165-0479 45.3 µM 0.797456918761139 0.317282318839077 no 1095 0.212592856853948 245 1377347 SGTC_34 0469-0683 81.75 µM 0.796225996389087 0.317534894477499 no 1096 0.212950345053308 216 3690923 SGTC_1914 st062367 72.6 µM 0.796150758068997 0.317550335548553 no 1097 0.212972207363918 240 978205 SGTC_1832 st054113 55 µM 0.792381530334012 0.318324295490843 no 1098 0.214069122732226 228 1251267 SGTC_876 0720-0963 56.8 µM 0.792312120591141 0.318338555295333 no 1099 0.21408935304204 232 765861 SGTC_9 0092-0002 10.449 µM 0.79116806649994 0.318573632937026 no 1100 0.214422961729577 253 759368 SGTC_2292 7671323 168.05 µM 0.790441297754559 0.318723005679025 no 1101 0.214635046015009 267 937504 SGTC_1359 1582-0056 520 nM 0.789334632477579 0.318950515110275 no 1102 0.214958225052853 245 3661189 SGTC_2000 st075254 36.4 µM 0.789100213549536 0.318998715964293 no 1103 0.215026718576878 229 17234175 SGTC_299 1273-0059 1.44 µM 0.788235141671266 0.319176617178301 no 1104 0.215279588622199 232 2848077 SGTC_186 3455-3465 67.277 µM 0.787729823042213 0.3192805547494 no 1105 0.215427378636714 244 755278 SGTC_1957 st077035 62.4 µM 0.784055457028448 0.320036751523802 no 1106 0.216503785197946 243 705593 SGTC_2917 7979103 53.79 µM 0.78318280275554 0.320216456760838 no 1107 0.216759886080599 216 2980565 SGTC_798 1287-0182 476 µM 0.781891095179004 0.320482534838215 no 1108 0.217139289369583 252 1649755 SGTC_900 1112-0045 141 µM 0.780281140361482 0.320814297673412 no 1109 0.217612705635817 224 56211 YIL048W NEO1 SGTC_247 mechlorethamine 29.705 µM 0.779499543417223 0.320975412721263 no 1110 0.217842753219996 220 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1408 3909-7976 48.8 µM 0.776184960403168 0.321659041028274 no 1111 0.218819892410024 257 24152374 SGTC_1489 4065-0444 182 µM 0.775603949171402 0.321778936129073 no 1112 0.218991433949019 239 2877968 SGTC_2368 9071271 200 µM 0.774780927520234 0.321948803274157 no 1113 0.21923456055143 237 27209959 SGTC_2638 epoxomicin 18 µM 0.773570326274556 0.322198732333437 no 1114 0.219592462801321 237 9915668 A protesome inhibitor. SGTC_2234 tolnaftate 200 µM 0.772471448481554 0.322425665676296 no 1115 0.219917625461586 246 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_485 niflumic acid 177 µM 0.770682980928193 0.322795150258904 no 1116 0.220447431052922 243 4488 A COX2 inhibitor. SGTC_2797 7859098 81.82 µM 0.770611600891754 0.322809900497002 no 1117 0.22046859144364 249 972681 SGTC_1526 st051518 75 µM 0.770563974659181 0.322819742315145 no 1118 0.220482710740189 227 673993 SGTC_1740 st038286 13.222 µM 0.768982837227415 0.323146550035218 no 1119 0.220951749606986 250 716786 SGTC_1230 0170-0365 3.77 µM 0.767587372423714 0.323435094249309 no 1120 0.221366183412147 245 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1411 3909-8223 150 µM 0.765374679121705 0.323892836809128 no 1121 0.222024233166124 254 X1411 SGTC_830 4076-0286 57.8 µM 0.765216116729865 0.323925649043694 no 1122 0.222071432090258 252 6866659 SGTC_575 k072-0246 11.9 µM 0.763604600557273 0.324259207002803 no 1123 0.222551453429927 242 6796779 SGTC_1729 st035615 45.989 µM 0.763263738916475 0.32432977797311 no 1124 0.222653061427519 257 17385451 SGTC_1480 1070-0044 41.2 µM 0.759371133175791 0.325136138368152 no 1125 0.223815288287549 246 3124987 SGTC_1747 st037496 66.6 µM 0.759361541590524 0.325138126296363 no 1126 0.223818156328006 260 723305 SGTC_1277 0873-0036 22 µM 0.759244614682408 0.325162360677953 no 1127 0.223853121060378 243 5965735 SGTC_276 colchicine 750 µM 0.756085742577375 0.325817351094575 no 1128 0.224798894778963 253 2833 A microtubule depolymerizer. SGTC_2371 9071574 200 µM 0.755926043812117 0.325850478849996 no 1129 0.224846769055439 253 45596039 SGTC_1109 tnp00067 928.257 nM 0.746462680089804 0.327815996858321 no 1130 0.227693983844077 243 676295 SGTC_836 0330-0104 1.35 µM 0.746360251831905 0.327837297204184 no 1131 0.227724911755513 253 46494820 SGTC_623 k072-0108 16.9 µM 0.744077700188549 0.328312107708135 no 1132 0.228414734689442 257 5382803 SGTC_2894 9048625 32.47 µM 0.742673569973794 0.328604329150259 no 1133 0.228839667510556 271 4092861 SGTC_2583 asiatic acid 100 µM 0.742569879778599 0.328625912859794 no 1134 0.228871064923981 283 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3226 9131256 49.47 µM 0.741832894328915 0.328779337082957 no 1135 0.229094293925352 233 17178073 SGTC_2436 5633522 8.09 µM 0.738909221552636 0.329388265830894 no 1136 0.229981061186537 261 5724242 SGTC_1244 0416-0015 52.5 µM 0.736880334390223 0.329811099092271 no 1137 0.230597562074452 245 96201 SGTC_859 0439-0102 54.6 µM 0.735022391686729 0.330198497299928 no 1138 0.231162928622077 274 610143 SGTC_978 1416-0512 87.4 µM 0.729276324403756 0.331397756381747 no 1139 0.232916325811598 272 6814003 SGTC_1364 1653-0028 37.6 µM 0.719627389475821 0.333415470363978 no 1140 0.235877221784495 246 5718652 SGTC_3082 9117008 49.47 µM 0.719491268154381 0.333443969727984 no 1141 0.235919140198694 265 41448529 SGTC_2427 5545055 42.75 µM 0.716954099710844 0.333975345835751 no 1142 0.236701209515666 264 5372858 SGTC_1906 st060206 94.7 µM 0.7143184251152 0.334527705454985 no 1143 0.237515150723609 284 5133468 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.713728786672315 0.334651325368352 no 1144 0.237697451172707 284 688801 SGTC_2078 5212016 200 µM 0.71347691537765 0.33470413659564 no 1145 0.237775346438066 264 1899708 SGTC_1504 k297-0033 30 µM 0.711798882649668 0.335056062283133 no 1146 0.238294662360904 226 4388117 SGTC_3079 9117512 49.47 µM 0.711533947318249 0.335111639137655 no 1147 0.238376711037327 316 7185044 SGTC_3301 9125354 19.7965 µM 0.711208887585668 0.335179833530739 no 1148 0.238477400965426 247 41905162 SGTC_2019 4016004 108 µM 0.707815607491597 0.335892034926357 no 1149 0.239529886399169 275 45595336 SGTC_1877 wortmannin 25 µM 0.707392305769324 0.335980921380058 no 1150 0.239661358543573 266 312145 A covalent inhibitor of PI 3-kinase. SGTC_1147 3809-1045 12.3 µM 0.706856635329373 0.336093416580179 no 1151 0.23982778742399 255 325925 SGTC_1640 st009078 66.4 µM 0.706709423911874 0.336124334761424 no 1152 0.239873535974514 268 690618 SGTC_184 1494-0393 24.714 µM 0.706408225769973 0.336187597567073 no 1153 0.239967153453312 277 3090647 SGTC_2466 5983409 37.09 µM 0.705794963276407 0.336316419824928 no 1154 0.24015782738089 261 2879657 SGTC_757 1066-0008 322 µM 0.703764578794389 0.336743060597894 no 1155 0.240789697946313 255 6842497 SGTC_2101 5377231 179.231 µM 0.702242326751426 0.337063066386644 no 1156 0.241264026681381 277 2844213 SGTC_1197 1601-0112 267 µM 0.700449441370338 0.337440115614006 no 1157 0.241823334465861 278 7350313 SGTC_968 1309-0633 340 µM 0.699282469133321 0.337685621165407 no 1158 0.242187760316132 273 3761976 SGTC_1926 methyl fluorone black 53.6 µM 0.698570295488266 0.337835480948274 no 1159 0.242410306395228 237 72721 Reacts with homocysteine. SGTC_1982 st072467 71.9 µM 0.686269623542731 0.340427900187028 no 1160 0.246271550256523 278 3163533 SGTC_80 0159-0065 512.242 µM 0.684524493759698 0.340796308812416 no 1161 0.246822013971757 262 1548079 SGTC_3155 9099265 49.47 µM 0.681889994861723 0.341352756891466 no 1162 0.247654256180386 275 25236499 SGTC_1124 fisetin 1.16336 µM 0.681366207345459 0.341463430311534 no 1163 0.247819899885241 278 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1127 asiatic acid 681.4 nM 0.678936435867557 0.341977005839757 no 1164 0.248589069041433 283 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_877 0771-0151 33.1 µM 0.677296637271169 0.342323771905356 no 1165 0.249108882021875 268 6166523 SGTC_161 4065-0411 162.148 µM 0.675051725355499 0.342798716096051 no 1166 0.24982145131057 278 1906281 YLR208W SEC13 SGTC_1590 st077108 57.8 µM 0.674554658628005 0.342903911523069 no 1167 0.249979374072485 251 5489485 SGTC_1455 4262-0120 131 µM 0.671212270233473 0.343611585170112 no 1168 0.251042656521441 279 1529587 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.671173003532624 0.343619902252505 no 1169 0.251055162271483 275 2724278 An inhibitor of dopamine biosynthesis. SGTC_573 3702-0553 84.7 µM 0.666310340016826 0.34465044734962 no 1170 0.252606378903155 270 1222756 SGTC_2354 9060492 162 µM 0.665675390962473 0.34478509754736 no 1171 0.252809303197518 286 6471895 SGTC_3344 9148862 3.898 µM 0.66398658618024 0.34514332886829 no 1172 0.253349448189435 294 4905352 SGTC_660 4031-1742 102 µM 0.663702161141984 0.34520367511927 no 1173 0.253440477952675 271 6738706 SGTC_2087 5276107 200 µM 0.663220737105396 0.345305827471856 no 1174 0.253594596079989 282 144405 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.661341702088064 0.345704643737377 no 1175 0.254196601719175 243 4000243 SGTC_1422 4031-0024 15.5 µM 0.660168014264084 0.34595384035044 no 1176 0.254573007964625 304 782427 SGTC_2991 9074669 71.4286 µM 0.65917347399217 0.34616505271493 no 1177 0.254892189267943 289 17333109 SGTC_986 1493-0483 84 µM 0.659076743249788 0.346185598157198 no 1178 0.254923244577038 285 40079 SGTC_2728 chlorpromazine 9.18 µM 0.656135127748985 0.346810608160796 no 1179 0.255868592165602 325 2726 A thorazine and dopamine antagonist. SGTC_1641 st009299 47.1 µM 0.654122299178915 0.347238517706846 no 1180 0.256516508008231 271 4046054 SGTC_401 neomycin 50 µM 0.652625867982487 0.347556772030696 no 1181 0.256998752349012 273 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2834 9001755 58.44 µM 0.652047891661035 0.347679722246445 no 1182 0.257185138883151 281 2989575 SGTC_3186 9110464 49.47 µM 0.65177487264213 0.347737805885684 no 1183 0.257273206835211 281 17018021 SGTC_3280 9140961 49.47 µM 0.64784805654975 0.348573614145814 no 1184 0.25854161483259 302 4901226 SGTC_2285 7945142 200 µM 0.639189296669885 0.350419193732521 no 1185 0.26134989710184 299 2970608 SGTC_3030 9087619 49.47 µM 0.63699917133846 0.35088657227498 no 1186 0.262062691682124 283 25236973 SGTC_3013 9080133 71.4286 µM 0.628611910465964 0.352678517900903 no 1187 0.26480158043926 297 17050193 SGTC_287 k060-0039 29.6 µM 0.625211270006831 0.353406002795263 no 1188 0.265916203056282 289 5861974 SGTC_2776 terbinafine 19.92 µM 0.624487151086515 0.353560979843668 no 1189 0.266153853012539 271 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3347 9188721 44.724 µM 0.623534682917495 0.353764865516303 no 1190 0.266466609008073 299 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_3102 9121669 49.47 µM 0.623482661837221 0.353776002375817 no 1191 0.266483696196378 311 41905072 SGTC_689 0833-0039 98 µM 0.623014659288824 0.353876199666339 no 1192 0.266637444328216 334 5374726 SGTC_2993 9054257 71.4286 µM 0.619942277635158 0.354534234131598 no 1193 0.267647895085668 303 6470217 YGL055W OLE1 SGTC_2624 nerol 100 µM 0.619585805576421 0.354610610522717 no 1194 0.267765257134349 316 637566 A natural product oil. SGTC_3282 9108498 15.4605 µM 0.618056615693703 0.354938315408372 no 1195 0.268269009569374 297 16459645 SGTC_2133 5320837 200 µM 0.616347926375239 0.355304613949702 no 1196 0.268832456947406 301 2841355 SGTC_670 4204-0025 119 µM 0.615794946827639 0.355423187037362 no 1197 0.269014931452981 298 719039 SGTC_3000 9075062 71.4286 µM 0.614455782374004 0.355710396428848 no 1198 0.269457091966829 276 17057871 SGTC_2096 5468907 200 µM 0.612599928808262 0.356108555090139 no 1199 0.27007045266344 297 759785 SGTC_1054 3429-0080 167 µM 0.612420207722256 0.35614712116615 no 1200 0.270129887664783 304 1162877 SGTC_1135 dihydrocapsaicin 536.708 nM 0.611061567518536 0.356438717302546 no 1201 0.270579410920852 331 107982 A Capsaicinoid. SGTC_2955 9076254 12.21 µM 0.609439982711666 0.356786857415326 no 1202 0.271116421405951 282 16459619 SGTC_1220 1838-0075 193 µM 0.606440282619717 0.357431181200173 no 1203 0.272111212959498 286 5529645 SGTC_1254 0550-0035 264 µM 0.605745177916322 0.357580545054585 no 1204 0.272341989466908 302 15121435 SGTC_2316 5844804 197.44 µM 0.605306828900988 0.357674748555116 no 1205 0.272487572416296 302 776813 SGTC_2837 9008476 45.46 µM 0.603153260486545 0.358137687535031 no 1206 0.273203368869702 310 2992805 SGTC_2858 9025781 8.96 µM 0.601329705169133 0.358529848863036 no 1207 0.273810204110533 282 4894980 YPL153C RAD53 SGTC_408 cantharidin 100 µM 0.601042732371704 0.35859157686947 no 1208 0.273905762403475 288 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2480 5767542 37.17 µM 0.600031088777198 0.358809211420617 no 1209 0.274242758301258 306 2867358 SGTC_1329 1447-1697 50.6 µM 0.599763710869757 0.358866740003971 no 1210 0.274331860682632 302 2840515 SGTC_3256 9138902 49.47 µM 0.598134031906163 0.359217448184091 no 1211 0.274875252066074 334 17228773 SGTC_1240 0356-0016 42.1 µM 0.596895250297275 0.359484114348063 no 1212 0.275288659303676 285 4305613 SGTC_3334 9142812 21.919 µM 0.596333441023885 0.3596050747166 no 1213 0.275476247579817 308 45283678 SGTC_1994 st072947 40.9 µM 0.596297083585537 0.359612903141103 no 1214 0.27548838950476 320 5286565 YDL195W SEC31 SGTC_2981 9013952 38.96 µM 0.593118001776893 0.3602976453169 no 1215 0.276551091885472 275 2996344 SGTC_2002 4023503 131 µM 0.59260546334303 0.360408082956483 no 1216 0.27672261098773 334 4736863 YCR052W RSC6 SGTC_2611 pyromycin 23.93 µM 0.589770401251712 0.361019169388114 no 1217 0.277672294496969 295 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_270 tamoxifen 5.46 µM 0.587729877651364 0.361459215938374 no 1218 0.278356808916869 325 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1062 mesoridazine 14.2 µM 0.585536978798649 0.361932327154859 no 1219 0.279093354827649 300 4078 A neuroleptic. SGTC_3055 9094636 49.47 µM 0.585224784421405 0.361999699316454 no 1220 0.279198290978037 301 25236176 SGTC_2558 carylophyllene oxide 100 µM 0.585137500710175 0.362018536078288 no 1221 0.279227632593855 320 6708694 An oxygenated terpenoid and antifungal agent. SGTC_853 0419-0306 21 µM 0.584916861314537 0.362066153918513 no 1222 0.279301810232524 317 762713 SGTC_841 0251-0215 91.2 µM 0.583890777742318 0.362287628738875 no 1223 0.279646899110987 328 3888614 SGTC_229 benomyl 22.8748 µM 0.583418454549155 0.36238959275254 no 1224 0.279805818738604 303 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1262 0737-0114 49.6 µM 0.581867706761571 0.362724433129057 no 1225 0.280327896976704 307 765919 SGTC_2076 5212012 200 µM 0.580314886676998 0.363059826177729 no 1226 0.280851145123125 306 604802 SGTC_956 1185-0240 191 µM 0.579781755042764 0.363175001324192 no 1227 0.281030901378046 301 1416193 SGTC_545 4218-0007 221 µM 0.579183434668892 0.363304274261915 no 1228 0.281232703529821 326 2840508 SGTC_1919 st067113 52.3 µM 0.576758853807686 0.36382828780489 no 1229 0.282051184322121 314 1268243 SGTC_549 1661-1316 519 µM 0.564420749736354 0.366498794106198 no 1230 0.286233910350327 334 2857282 SGTC_1280 0880-0253 10.1 µM 0.563580089973813 0.366680986837604 no 1231 0.286519969963012 326 6836607 SGTC_1101 ebselen 5.29 µM 0.560184135893196 0.367417283412266 no 1232 0.287676923316142 332 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1784 st039334 36.3 µM 0.558776638943857 0.367722594137085 no 1233 0.288157083829445 343 3496984 SGTC_1613 st002381 52.1 µM 0.555285038309279 0.368480344027409 no 1234 0.289349855465004 306 551167 SGTC_3314 9135860 59.4275 µM 0.553211051599981 0.368930684714656 no 1235 0.290059450103631 321 25252478 SGTC_1397 3532-0190 20.1 µM 0.550480175591301 0.369523935304002 no 1236 0.290995035269215 301 5322280 SGTC_1144 3486-0183 12.5 µM 0.54942397287135 0.369753466302613 no 1237 0.291357263037415 347 6744069 SGTC_269 exalamide 29 µM 0.545173291907127 0.370677680831367 no 1238 0.292817169314561 315 3316 A derivative of salicylamide. SGTC_565 1418-0001 44.5 µM 0.544924340118762 0.370731832972028 no 1239 0.292902777561029 330 2862145 SGTC_1760 st045453 10.4495 µM 0.544066062109357 0.370918545740422 no 1240 0.29319800676004 335 3323419 YIL048W NEO1 SGTC_196 k015-0023 18.111 µM 0.543140562202817 0.371119916252681 no 1241 0.29351651335853 317 5211998 SGTC_613 3914-0030 117 µM 0.542330408150455 0.37129621875513 no 1242 0.293795455661697 303 1145395 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.539341200894518 0.37194695156695 no 1243 0.294825722402243 328 5106787 A p450 inhibitor. SGTC_81 0411-0046 9.971 µM 0.538895862358461 0.372043930509367 no 1244 0.29497935619685 319 12925265 SGTC_151 3013-0144 2.285 µM 0.531827538528842 0.373584243925561 no 1245 0.297422723856943 345 906558 YHR107C CDC12 SGTC_95 0471-0001 561.058 µM 0.531539663882727 0.373647019938495 no 1246 0.297522431553112 301 4015405 SGTC_1756 st041558 35.5 µM 0.53098645473776 0.373767666108469 no 1247 0.297714082813677 341 3955792 SGTC_3170 9103054 49.47 µM 0.529151740596892 0.374167876742814 no 1248 0.298350095626195 331 16432970 SGTC_3205 9113483 49.47 µM 0.529138939971148 0.374170669451283 no 1249 0.298354535198868 368 17018033 SGTC_2035 5154463 94.595 µM 0.526741589830688 0.374693814849365 no 1250 0.299186524956858 362 2769623 SGTC_2587 piperic acid 92.2 µM 0.52461619671217 0.375157807252344 no 1251 0.299925012506147 317 5370536 SGTC_2282 7944268 200 µM 0.522741486036284 0.375567223450243 no 1252 0.300577082048552 329 2970414 SGTC_1661 st013063 9.66 µM 0.518429245440196 0.376509500717302 no 1253 0.302079407140606 350 721395 SGTC_1931 st074438 57.1 µM 0.514203677964834 0.37743355325605 no 1254 0.303554798292445 339 2787313 SGTC_678 1218-2179 85.9 µM 0.51306183025775 0.377683374700997 no 1255 0.303954035261802 349 6820081 YOR116C RPO31 SGTC_992 3909-8734 162 µM 0.51211768884359 0.377889979234144 no 1256 0.304284322688933 334 4288319 SGTC_448 monastrol 171 µM 0.511914124876963 0.377934529300178 no 1257 0.30435555607464 352 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_663 1486-0733 13.9 µM 0.511689843351133 0.377983615293026 no 1258 0.304434047776016 332 722445 YPR165W RHO1 SGTC_1332 1480-0653 17.5 µM 0.511408543101176 0.378045183121969 no 1259 0.304532507028271 333 5749438 SGTC_2207 7258803 200 µM 0.509637686923958 0.378432839233363 no 1260 0.305152657949195 349 3666799 SGTC_1971 st069429 63.5 µM 0.505652829773031 0.379305606782065 no 1261 0.30655019381002 335 1246522 YGL099W LSG1 SGTC_2021 4019055 173 µM 0.505420559083078 0.379356497975572 no 1262 0.306631740949289 331 44827708 YER133W GLC7 SGTC_3 0833-0587 95.581 µM 0.502792895149569 0.379932372301902 no 1263 0.307554944690603 334 5382644 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.500699833275829 0.380391274800748 no 1264 0.308291194817592 348 364106 SGTC_724 3910-0327 137 µM 0.497492744280179 0.381094753532837 no 1265 0.309420809135655 366 2885483 SGTC_2337 9009472 200 µM 0.497378052769587 0.38111991854511 no 1266 0.309461239717942 360 5742383 SGTC_2228 7354201 200 µM 0.496018842027264 0.381418187724038 no 1267 0.309940558651894 368 753451 SGTC_730 1436-0052 41.2 µM 0.495271556104484 0.38158220435357 no 1268 0.310204223093693 316 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_843 0310-0051 143 µM 0.495024747335568 0.381636379379744 no 1269 0.310291325929437 351 2065037 SGTC_2158 5657123 3.6195 µM 0.494922573335178 0.381658807459085 no 1270 0.310327387913966 392 2858827 SGTC_2401 5128683 200 µM 0.494572039325514 0.381735755733966 no 1271 0.310451121622922 353 708373 SGTC_1972 st070201 17.4 µM 0.494274649843581 0.381801041530741 no 1272 0.31055611286195 338 2829099 SGTC_2686 alizarin 95.37 µM 0.492848561644585 0.382114156802122 no 1273 0.311059797484377 304 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2451 5856223 45.7 µM 0.489584456429469 0.38283112135781 no 1274 0.312213988838201 323 2179896 SGTC_1153 4055-0057 267 µM 0.48917480548133 0.382921130089985 no 1275 0.312358972448118 341 882706 SGTC_2669 eugenol 100 µM 0.486410237855538 0.383528727496962 no 1276 0.313338166639476 340 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1366 1683-0113 21.9 µM 0.484836693462826 0.383874689559121 no 1277 0.31389609593375 334 708623 SGTC_1916 st067606 49.2 µM 0.483994541039573 0.384059884625764 no 1278 0.314194871662884 353 19590279 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.48250588356518 0.384387315308902 no 1279 0.314723309924869 330 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2992 9074591 71.4286 µM 0.481991281948744 0.384500521300103 no 1280 0.314906069711925 341 17741321 SGTC_427 1354-0053 47.3 µM 0.481873504626379 0.384526432240007 no 1281 0.314947904481156 362 6813657 SGTC_2515 chrysin 20.77 µM 0.479160842151287 0.385123358904462 no 1282 0.315912104487671 334 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_597 k018-0003 82.8 µM 0.478169294799465 0.385341618869243 no 1283 0.316264857459665 363 6786234 SGTC_73 0327-0325 16.231 µM 0.477894922098373 0.385402020362351 no 1284 0.316362497877134 314 53298 SGTC_2694 st077685 81.9 µM 0.47771092511821 0.385442527743522 no 1285 0.31642798365545 317 2838096 SGTC_3201 9113999 49.47 µM 0.476697156969589 0.385665733658607 no 1286 0.316788893826265 356 16649224 SGTC_1415 3966-0071 78.1 µM 0.476075489634053 0.385802627700391 no 1287 0.317010299048909 350 2893185 SGTC_2423 st077119 87.2 µM 0.474183233783874 0.386219398719829 no 1288 0.317684624165837 330 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_10 0279-0212 42.575 µM 0.464209744816717 0.388418228038547 no 1289 0.321248740074449 334 39851 YBR002C RER2 SGTC_1700 st030840 7.9285 µM 0.462554552910348 0.388783492249051 no 1290 0.321841845463953 368 5499307 SGTC_228 caffeine 993.056 µM 0.461837840631676 0.388941685311959 no 1291 0.3220988061917 335 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3093 9117344 49.47 µM 0.461379885389282 0.389042775047011 no 1292 0.322263040077374 335 24824913 SGTC_489 paxilline 115 µM 0.460724239732758 0.389187516338214 no 1293 0.322498230956434 346 105008 A toxic potassium channel blocker. SGTC_2895 9054447 58.44 µM 0.454791245506938 0.390497989679664 no 1294 0.324629714520077 357 2697450 SGTC_1111 tnp00062 510.699 nM 0.448441520298507 0.39190188915342 no 1295 0.326917291084812 335 676306 SGTC_754 3474-0146 171 µM 0.447969311622049 0.392006349146455 no 1296 0.327087672307179 330 24762078 SGTC_3112 9123419 49.47 µM 0.446804246560557 0.392264113161547 no 1297 0.327508202453192 380 17015854 SGTC_1215 3852-0577 11.2 µM 0.446716803937176 0.392283461253178 no 1298 0.327539773701053 340 2884876 SGTC_2585 alliin 100 µM 0.445677770570123 0.392513384522875 no 1299 0.327915012089439 382 87310 A garlic compound which reacts with lipids. SGTC_2325 6158266 200 µM 0.445445190852571 0.392564856240518 no 1300 0.327999030167096 336 3623240 SGTC_2796 7949634 45.45 µM 0.442761454069995 0.393158923993981 no 1301 0.32896914337083 362 2971588 SGTC_1308 1187-1617 41.4 µM 0.44231504377245 0.393257764855044 no 1302 0.329130623143472 364 2882570 SGTC_3185 9108267 49.47 µM 0.439597116014554 0.393859696538363 no 1303 0.33011446493373 360 4910486 SGTC_3309 9129340 25.759 µM 0.438998387987733 0.393992329267072 no 1304 0.330331352186692 340 17158987 SGTC_345 1362-0200 395 µM 0.432153287756095 0.395509554688906 no 1305 0.332815003624549 342 1419823 SGTC_1439 4092-1168 46 µM 0.430466491453285 0.395883679606804 no 1306 0.333428168331548 373 2886240 SGTC_1530 rhein 70.4 µM 0.427539560057252 0.396533089189625 no 1307 0.334493188723761 364 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3294 9122953 26.2835 µM 0.427380410938513 0.396568408466622 no 1308 0.334551136492321 371 16459826 SGTC_2134 5324836 1.464 µM 0.426082945937863 0.396856380912833 no 1309 0.335023703280203 370 699272 SGTC_3100 9120536 49.47 µM 0.423279031182593 0.397478901945357 no 1310 0.336045845657873 368 16421196 SGTC_3171 9103192 49.47 µM 0.421208712792013 0.397938718724324 no 1311 0.336801341337122 376 13018434 SGTC_1146 3579-1023 7 µM 0.420676932649152 0.398056849768311 no 1312 0.336995503784389 377 X1146 SGTC_2159 5658611 73.75 µM 0.419768417602127 0.398258691314317 no 1313 0.337327319366935 380 793844 SGTC_3163 9099914 49.47 µM 0.418327381983093 0.398578896875686 no 1314 0.337853886134896 389 16268368 SGTC_2452 5863136 48.41 µM 0.418251132629129 0.398595841780323 no 1315 0.337881757155418 359 2184096 SGTC_3220 9131269 49.47 µM 0.41728542215229 0.398810468287896 no 1316 0.338234825039206 369 17722206 SGTC_1034 k072-0165 12.7 µM 0.417141796820251 0.398842391240088 no 1317 0.338287347238091 386 5835461 SGTC_127 0180-0333 59.125 µM 0.416833980571254 0.398910810442937 no 1318 0.338399922841321 340 771601 SGTC_1636 st007707 68.9 µM 0.411533240316888 0.400089506837489 no 1319 0.340340786282342 422 403051 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.41008923591398 0.400410760436855 no 1320 0.340870244274224 371 1377 SGTC_1051 3253-3903 78 µM 0.409727099109951 0.400491337078698 no 1321 0.341003074413207 375 5509239 SGTC_541 4513-1321 94 µM 0.409649890085207 0.400508516891008 no 1322 0.341031396883314 362 747515 SGTC_246 cycloheximide 667 µM 0.406995042267425 0.401099365067349 no 1323 0.342005814734355 380 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_785 1270-0111 65.3 µM 0.406912175652403 0.4011178110491 no 1324 0.34203624653434 352 6741994 SGTC_770 0389-1121 67.2 µM 0.406032902828902 0.401313549404474 no 1325 0.342359212421863 353 6753108 SGTC_1853 st056710 91.2 µM 0.403787192940014 0.401813587956532 no 1326 0.343184607518513 390 269167 SGTC_1075 aripiprazole 15.2 µM 0.402686807106739 0.40205866291683 no 1327 0.343589320262061 353 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2644 guaiazulene 100 µM 0.399650672265526 0.402735062114957 no 1328 0.344706914349256 377 3515 A coloring agent. SGTC_1223 0764-0573 147 µM 0.399405412955964 0.402789714457299 no 1329 0.34479725307215 364 1609797 SGTC_2513 baicalein 25.65 µM 0.399265437447337 0.402820906742172 no 1330 0.344848815565965 368 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1806 st050005 60.3 µM 0.3983702942912 0.403020395972129 no 1331 0.345178625737154 376 5194765 SGTC_2775 cyproheptadine 69.59 µM 0.39768599893784 0.403172913248956 no 1332 0.345430829634097 394 2913 A selective serotonin reuptake inhibitor. SGTC_2690 usnic acid 100 µM 0.395869176940097 0.40357792201163 no 1333 0.34610077034846 397 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2967 9089538 49.85 µM 0.395706240323977 0.403614249153313 no 1334 0.346160875693763 374 728216 SGTC_3002 9075603 71.4286 µM 0.393470094872801 0.404112887475988 no 1335 0.34698615366281 368 20105405 SGTC_2384 9036245 200 µM 0.393030717797389 0.404210882562404 no 1336 0.347148396872705 365 6462766 SGTC_2911 7942208 15.64 µM 0.391187289921608 0.404622091154693 no 1337 0.347829401230269 355 1243384 SGTC_614 0462-0418 107 µM 0.390009934755157 0.404884775832313 no 1338 0.348264600317117 376 5188303 SGTC_3199 9111318 49.47 µM 0.387978964843396 0.405338014787401 no 1339 0.349015800166147 380 8548020 SGTC_2369 9071472 200 µM 0.385678435448474 0.405851563005623 no 1340 0.349867417770403 366 17296037 SGTC_1801 st050089 28.441 µM 0.385481192361855 0.40589560122478 no 1341 0.34994046911023 365 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2299 7976368 114.88 µM 0.382567967663815 0.406546171685574 no 1342 0.351020062347031 366 2979718 SGTC_2242 6630449 61.2675 µM 0.382516317865476 0.406557708258891 no 1343 0.351039213798593 382 691249 YDR170C SEC7 SGTC_3192 9110362 49.47 µM 0.381487777264862 0.406787461444473 no 1344 0.351420669539579 394 16649480 SGTC_838 0109-0203 71.4 µM 0.379845500721453 0.40715437613091 no 1345 0.352030052265529 367 759422 SGTC_2395 5646831 180.19 µM 0.378500396205515 0.407454957860955 no 1346 0.352529449747566 399 6808628 SGTC_2453 5731132 22.18 µM 0.375963698907947 0.408021965221078 no 1347 0.353471941779732 389 1362040 SGTC_944 3370-0224 231 µM 0.374031442024985 0.408453996266552 no 1348 0.35419046190289 351 4580514 SGTC_510 ag-490 170 µM 0.371924436362013 0.408925226014459 no 1349 0.354974555296284 370 5328779 SGTC_627 1391-0720 175 µM 0.37167526107833 0.408980962541631 no 1350 0.355067323180084 428 997839 SGTC_917 harmaline 728.087 nM 0.371529960875268 0.409013464723609 no 1351 0.355121422368485 356 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1312 1218-2183 165 µM 0.371020481636645 0.409127435004075 no 1352 0.355311138311329 380 6744073 SGTC_548 1436-0017 110 µM 0.370338360783417 0.409280037164195 no 1353 0.355565197351013 399 9677137 SGTC_766 1391-0721 126 µM 0.369766382165858 0.409408009211868 no 1354 0.355778282891795 404 1020919 YIL115C NUP159 SGTC_446 go6976 132 µM 0.369525104304618 0.409461994583692 no 1355 0.355868182330464 417 3501 A protein kinase C inhibitor. SGTC_3252 9135871 49.47 µM 0.367416523070121 0.409933857787376 no 1356 0.356654174268966 396 17682838 SGTC_1434 4073-0095 163 µM 0.366512335262974 0.410136239039971 no 1357 0.35699140490671 397 24133745 SGTC_977 1348-1378 135 µM 0.365161246385328 0.410438693218127 no 1358 0.357495522340516 397 X977 SGTC_1389 3405-0187 19 µM 0.365060708888313 0.410461201631004 no 1359 0.357533044782841 381 799890 SGTC_2903 5923464 63.88 µM 0.364787265882507 0.410522421755102 no 1360 0.357635105705676 390 2876576 SGTC_2664 lyso-paf C-16 73.48 µM 0.359008006949611 0.411816825981822 no 1361 0.359794549681467 395 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_805 3852-0218 479 µM 0.359001822992092 0.411818211544786 no 1362 0.359796862756087 388 6615355 SGTC_2647 atorvastatin 60.16 µM 0.357061256407845 0.412253064546365 no 1363 0.360522974050703 395 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2091 4-phenylthiadiazole 200 µM 0.35558118646766 0.412584799347035 no 1364 0.361077117508993 377 270010 SGTC_1735 st034310 56.75 µM 0.355546279072263 0.41259262405491 no 1365 0.361090190487519 433 871153 SGTC_2751 anetholtrithion 17.25 µM 0.354433804212702 0.412842010330027 no 1366 0.361506902294508 397 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2600 tangeritin 87.95 µM 0.353519869218444 0.413046915755073 no 1367 0.361849367849252 388 68077 A bioactive flavone. SGTC_256 clotrimazole 625 nM 0.350291114653182 0.413770996090458 no 1368 0.363060116427417 383 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1379 2144-0755 36.5 µM 0.348932599409068 0.414075744454098 no 1369 0.363569955343034 420 5392327 SGTC_1941 st076221 61.8 µM 0.345745844692261 0.414790814623839 no 1370 0.364766863739352 368 2828568 SGTC_1743 st037606 46.3785 µM 0.344509294116938 0.415068358175942 no 1371 0.365231653826984 352 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3121 9125696 49.47 µM 0.342979600962392 0.415411756170877 no 1372 0.365806903235042 417 1235365 SGTC_140 0062-0056 502.533 µM 0.342852440396847 0.415440305124382 no 1373 0.365854736262463 360 3758964 SGTC_3308 9128332 17.569 µM 0.341642665055727 0.415711935375024 no 1374 0.366309912496785 403 17332805 YDL196W YDL196W SGTC_1156 4092-0367 4.88 µM 0.339372474551271 0.416221768722613 no 1375 0.367164575808598 402 1357585 SGTC_1834 st055981 52.8 µM 0.337911740590444 0.416549891078052 no 1376 0.367714849871803 413 471719 YDL150W RPC53 SGTC_938 3126-1755 342 µM 0.336682953993678 0.41682595651195 no 1377 0.368177957328728 401 1777771 SGTC_1874 staurosporine 7.6 µM 0.334537122812498 0.417308148126327 no 1378 0.368987141465062 407 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1080 nisoldipine 24.4 µM 0.333659802045006 0.417505327514917 no 1379 0.369318143071256 428 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2586 curcumin 80 µM 0.33233761493632 0.417802530574263 no 1380 0.369817169908849 386 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.332308315914868 0.417809116981478 no 1381 0.36982823058698 370 16623 A steroid. SGTC_2806 7952793 58.44 µM 0.325601541432759 0.419317400023488 no 1382 0.372362922902558 382 2972490 SGTC_2715 st079500 56.4 µM 0.323761407414015 0.419731435150388 no 1383 0.373059338075187 409 28246688 SGTC_141 0443-0274 32.331 µM 0.321788245440613 0.420175500656475 no 1384 0.37380655992207 386 1627241 SGTC_1706 st031321 9.9705 µM 0.320407349007758 0.420486335667605 no 1385 0.374329777634774 391 6103185 SGTC_2262 9014885 67.46 µM 0.320239629911269 0.42052409203725 no 1386 0.374393341708491 415 6457424 SGTC_78 0336-0123 156.75 µM 0.317198125973488 0.421208911896939 no 1387 0.375546635907562 390 6765896 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.316781555320457 0.42130272484844 no 1388 0.375704680348163 380 6708739 YPR165W RHO1 SGTC_2838 9002687 71.43 µM 0.316774274580933 0.421304364532403 no 1389 0.37570744280318 409 6457060 SGTC_714 4296-0578 26.1 µM 0.315478410163693 0.421596225843751 no 1390 0.376199220474481 405 1589775 SGTC_533 1222-0222 6.71 µM 0.314831421121169 0.421741960207331 no 1391 0.376444826688957 425 3982874 SGTC_2305 7443522 69.23 µM 0.313961202699176 0.421937993917467 no 1392 0.376775252829965 416 5415886 SGTC_2563 tomatine 8.54 µM 0.312411551913619 0.422287130912653 no 1393 0.377363886129289 445 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2226 7298446 200 µM 0.311493193606574 0.422494066277202 no 1394 0.377712858209914 426 3283010 SGTC_1816 st051957 91.6 µM 0.311266595440512 0.422545129351064 no 1395 0.377798979874482 417 674121 SGTC_2079 5212404 121 µM 0.310292485851043 0.422764656224485 no 1396 0.378169272392232 391 758462 SGTC_2495 cafestol 54.53 µM 0.304894055297669 0.423981688070706 no 1397 0.380223421762275 415 16667697 An anti-infammatory. SGTC_3268 9137683 49.47 µM 0.304570334341808 0.424054691470029 no 1398 0.380346708458275 457 1953228 SGTC_1227 3909-8010 46.6 µM 0.302985951446387 0.424412028520329 no 1399 0.380950283913368 411 15982272 SGTC_2934 9036370 36.88 µM 0.302372419203824 0.4245504194812 no 1400 0.38118408879441 414 6462800 SGTC_2489 cantharidin 73.42 µM 0.30197224562917 0.424640689360005 no 1401 0.381336610328178 428 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_718 1130-0073 349 µM 0.300351639654625 0.425006300854389 no 1402 0.381954473807672 419 6740020 SGTC_2816 7982706 58.44 µM 0.29935930979698 0.425230204043081 no 1403 0.382332952715785 393 2981853 SGTC_647 0140-0236 81 µM 0.298789647894395 0.425358749942933 no 1404 0.382550275061188 413 990837 SGTC_38 0929-0051 58.268 µM 0.297475555450574 0.425655309047487 no 1405 0.383051733849261 435 1379719 SGTC_806 3966-4455 5.86 µM 0.296812624921603 0.425804932518504 no 1406 0.383304783153152 402 714982 SGTC_55 0767-0285 6.563 µM 0.289049291167796 0.427557907058731 no 1407 0.386271828863252 434 3116166 SGTC_1804 st050076 49.1 µM 0.288704888276811 0.427635707248921 no 1408 0.38640361081059 414 3895976 SGTC_686 1319-0111 510 µM 0.288499415632846 0.427682124607267 no 1409 0.386482238881333 447 4562600 SGTC_2514 salinomycin 42.74 µM 0.288055962868701 0.427782306345408 no 1410 0.386651950516883 430 23682228 A polyether potassium ionophore. SGTC_2275 7947463 200 µM 0.288045838234373 0.42778459368617 no 1411 0.386655825519363 418 1225414 SGTC_740 k014-0057 261 µM 0.287677062432377 0.427867908563301 no 1412 0.386796974824388 448 4012779 SGTC_1655 st012546 55.1 µM 0.286339952895928 0.42817001909374 no 1413 0.387308880283329 441 720985 YLR208W SEC13 SGTC_1658 st012944 20 µM 0.284729968425575 0.428533839662251 no 1414 0.387925514541008 434 24207260 SGTC_1903 st060211 78.3 µM 0.283824166634674 0.428738557378486 no 1415 0.388272566746966 401 688960 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.283726324653946 0.428760671517874 no 1416 0.388310059625424 437 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1549 4'-methoxyflavonol 74.6 µM 0.283463955183737 0.4288199730875 no 1417 0.388410604291213 429 97141 SGTC_1343 1487-0095 224 µM 0.279607457055961 0.429691815585193 no 1418 0.389889342659295 443 4560101 YGL055W OLE1 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.278865661210634 0.42985955359843 no 1419 0.3901739609586 403 5355888 SGTC_1012 4112-3522 18 µM 0.278608509742957 0.42991770473257 no 1420 0.390272640689289 412 3112398 SGTC_1917 st066507 28.5 µM 0.277693204350938 0.430124700311006 no 1421 0.390623938826363 415 3156428 SGTC_699 0375-0592 111 µM 0.277276041087181 0.430219047822454 no 1422 0.390784077518747 415 762578 SGTC_3219 9131112 49.47 µM 0.277047023340112 0.430270845195858 no 1423 0.390871999663659 402 17612988 YMR079W SEC14 SGTC_1659 st012954 42.1 µM 0.27665672310274 0.430359122897131 no 1424 0.39102185258122 417 24207262 SGTC_451 chloral hydrate 100 µM 0.276118829276534 0.43048078886575 no 1425 0.391228399489609 433 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1734 st037168 69.4 µM 0.275082619665195 0.430715187256342 no 1426 0.391626382085611 389 708907 SGTC_234 nsc-17383 10.7 µM 0.273279066937337 0.431123222591393 no 1427 0.392319352641475 414 408974 SGTC_3338 9144300 39.5675 µM 0.271082273789228 0.431620323822908 no 1428 0.393163877387107 400 4901274 SGTC_1996 st072960 66.8 µM 0.267877982627098 0.432345600696982 no 1429 0.394396620919907 429 1719405 SGTC_484 loperamide 105 µM 0.267554718338957 0.432418782816402 no 1430 0.394521044990959 412 3955 An opioid-receptor agonist. SGTC_349 k015-0014 24 µM 0.26692226107416 0.432561968227522 no 1431 0.394764508214617 410 2196908 SGTC_3315 9136395 68.55 µM 0.265489567021508 0.432886356286606 no 1432 0.395316172949126 468 16876844 SGTC_2850 9015429 58.44 µM 0.262836063469581 0.433487277185172 no 1433 0.396338468929958 437 6457570 SGTC_563 tetrahydrosecaminediol 614 µM 0.258528050260956 0.434463210564885 no 1434 0.397999701774286 417 334274 A psychoactive constituent of the cannabis plant. SGTC_2216 7189485 200 µM 0.258118839347384 0.434555933701841 no 1435 0.398157596207176 439 731273 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.257589460327273 0.434675891080885 no 1436 0.398361882362688 450 91467 include heat shock SGTC_1510 1123-0200 71.5 µM 0.257236884203103 0.434755788229815 no 1437 0.398497956143603 426 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2244 6635614 200 µM 0.256452919473053 0.434933451740115 no 1438 0.398800564925751 410 836499 SGTC_3134 9127454 49.47 µM 0.255544457977386 0.435139345364488 no 1439 0.399151305299896 454 24262820 SGTC_2813 7971799 71.43 µM 0.253588134301393 0.435582786015295 no 1440 0.39990688225286 432 2234054 SGTC_3095 9117207 49.47 µM 0.251330981920776 0.436094516245722 no 1441 0.400779111810131 452 17015229 SGTC_954 1189-0853 2.85 µM 0.249716441360518 0.436460622448334 no 1442 0.401403321287111 410 2828194 SGTC_881 0833-0569 170 µM 0.248382638793774 0.436763110799448 no 1443 0.401919182506762 400 5418700 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.244356193761522 0.437676477579941 no 1444 0.403477482919467 455 6728940 SGTC_346 4513-0042 7.16 µM 0.243955045155617 0.437767493201459 no 1445 0.403632818439711 418 2827372 SGTC_2493 resveratrol 26.09 µM 0.240182145013849 0.438623677710132 no 1446 0.405094527412028 426 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3035 9091303 49.47 µM 0.239918417203125 0.438683536271341 no 1447 0.405196751459334 453 25237002 SGTC_420 mitomycin C 81.9 mM 0.229841438086923 0.440971756259731 no 1448 0.409107491816881 418 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3020 9089140 49.47 µM 0.229699017852737 0.441004110505061 no 1449 0.409162829071847 413 17217859 SGTC_1410 3909-8106 77.9 µM 0.229193932063673 0.441118856289161 no 1450 0.40935909429198 457 1039210 SGTC_1324 1418-0026 34.4 µM 0.228982854575713 0.441166810502813 no 1451 0.409441121092267 432 1372513 SGTC_1038 k292-0204 154 µM 0.228594517127564 0.441255038255856 no 1452 0.40959204322142 433 4454212 SGTC_758 0868-0029 16 µM 0.227944231733002 0.441402785412021 no 1453 0.409844797890672 422 762687 SGTC_2020 4017018 200 µM 0.227507142765222 0.441502098165128 no 1454 0.410014707863793 442 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_921 1561-0023 372 µM 0.227170816153335 0.441578518799837 no 1455 0.410145459903587 456 24050882 SGTC_1331 1472-0049 76.2 µM 0.226509769096468 0.441728729234395 no 1456 0.410402481012683 468 24051409 SGTC_258 haloperidol 50.781 µM 0.22426224144323 0.442239499921495 no 1457 0.411276627451362 472 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3233 9132340 49.47 µM 0.224153747130183 0.442264158657625 no 1458 0.411318836077511 467 17682950 SGTC_1310 1188-0297 994 nM 0.223280897454933 0.442462549259164 no 1459 0.411658446812358 443 1588352 SGTC_2192 5915882 198.485 µM 0.222518818639817 0.442635774476908 no 1460 0.411955012652823 446 2876149 SGTC_1358 1509-0022 2.48 µM 0.219592312628536 0.443301088990329 no 1461 0.413094339461942 416 3258434 SGTC_2003 4023581 200 µM 0.217111834690852 0.443865128340639 no 1462 0.414060595593895 439 16641307 SGTC_3104 9120930 49.47 µM 0.215650165921461 0.444197552576406 no 1463 0.414630224477857 456 17014836 SGTC_2469 5655019 90.81 µM 0.21542874473255 0.444247913358906 no 1464 0.414716530515465 466 2788239 SGTC_3084 9116877 49.47 µM 0.214328026331379 0.444498277811285 no 1465 0.415145631976103 463 27241325 SGTC_2487 5918373 44.05 µM 0.211955469891179 0.445038004004427 no 1466 0.416070887424717 494 2876279 SGTC_199 4063-0024 41.6 µM 0.211575972575558 0.445124344261024 no 1467 0.416218928034132 463 306215 SGTC_1282 0886-0010 32.4 µM 0.210503004397833 0.445368471647757 no 1468 0.416637553512159 473 2836211 YNL267W PIK1 SGTC_1166 k206-0078 225 µM 0.203818045583734 0.446889931847881 no 1469 0.419247845251761 415 5404595 SGTC_3254 9136651 49.47 µM 0.203390620335212 0.446987238342159 no 1470 0.419414865242976 475 16454030 SGTC_907 3448-6986 75.5 µM 0.201030624383721 0.447524566040765 no 1471 0.420337314029923 441 590582 SGTC_1694 st024011 44.9 µM 0.200083118776936 0.447740322805201 no 1472 0.420707787840641 458 2787533 SGTC_82 0054-0107 293.755 µM 0.19898797144083 0.447989718369966 no 1473 0.421136076920856 465 3104697 SGTC_468 gf-109203x 121 µM 0.195989878320555 0.448672572614868 no 1474 0.422309044147083 465 2396 A protein kinase C inhibitor. SGTC_3053 9095903 49.47 µM 0.195419996359524 0.448802387820025 no 1475 0.422532081775831 478 17174018 SGTC_688 0527-0193 473 µM 0.195214128163977 0.448849284532548 no 1476 0.422612659579613 471 4007154 SGTC_2504 purpurogallin 52.29 µM 0.195165648024216 0.448860328397676 no 1477 0.42263163541115 432 5281571 An antioxidant. SGTC_1497 4476-2978 41.3 µM 0.193550910006665 0.449228191279035 no 1478 0.423263769663512 478 1528379 SGTC_2252 omeprazole 400 µM 0.193303337646517 0.449284596048366 no 1479 0.423360706281462 474 4594 A proton pump inhibitor. SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.193118995026656 0.449326595760124 no 1480 0.42343288839488 474 6708630 An antioxidant. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.19143172885064 0.449711040470656 no 1481 0.424093681835637 478 688798 SGTC_215 1287-0124 461.5 µM 0.190713389809578 0.449874728842434 no 1482 0.424375073843868 464 5560863 SGTC_2526 patulin 37.61 µM 0.189829667003805 0.45007611501466 no 1483 0.424721303829814 431 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2727 riluzole 51.77 µM 0.186837661209157 0.45075804002075 no 1484 0.425893958724937 469 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_919 tnp00227 403.569 nM 0.186401470449363 0.450857466919819 no 1485 0.426064969693501 466 1269246 A methoxyflavone. YNL221C POP1 SGTC_1777 st045864 34.765 µM 0.182657415924152 0.451711026438319 no 1486 0.427533415352829 473 4691462 SGTC_816 0325-0417 81.3 µM 0.18206907815284 0.451845174507523 no 1487 0.427764257585074 470 68101 SGTC_1202 1988-0068 29.6 µM 0.181921832789872 0.451878749077408 no 1488 0.427822035154271 451 2850480 SGTC_1205 4161-2785 76 µM 0.179861179140402 0.452348650878742 no 1489 0.428630776337647 423 3498106 SGTC_1503 4585-0012 61.3 µM 0.178146821154061 0.452739635937577 no 1490 0.429303836062388 451 2922052 SGTC_2075 5212009 200 µM 0.177313894801141 0.452929613853479 no 1491 0.429630918625342 491 780898 SGTC_679 0422-0091 41.4 µM 0.1761474748768 0.453195674713909 no 1492 0.430089042211925 481 627384 YHR062C RPP1 SGTC_2714 st079313 56.9 µM 0.174967471513097 0.453464855342265 no 1493 0.43055259662094 462 2939799 SGTC_827 3253-0474 693 µM 0.173855532446916 0.453718528812693 no 1494 0.43098950014743 448 5402065 SGTC_3152 9099253 49.47 µM 0.17360996670427 0.453774553779041 no 1495 0.431085999339157 471 25236131 SGTC_2210 7115885 190.385 µM 0.172470554591971 0.454034518690913 no 1496 0.431533804247817 492 2927039 SGTC_1895 st058434 18.3 µM 0.171302312656803 0.454301081777056 no 1497 0.431993031052922 474 5393175 SGTC_482 fipronil 114 µM 0.169645977390386 0.454679050595438 no 1498 0.432644280932896 453 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2399 5884133 200 µM 0.169566790212156 0.454697121810729 no 1499 0.432675420918325 439 722445 SGTC_547 1120-0019 610 nM 0.169463087414401 0.454720787849278 no 1500 0.432716202188159 464 3676939 SGTC_481 bay k-8644 50 µM 0.168181936944946 0.455013172714744 no 1501 0.433220075382326 466 2303 A calcium channel antagonist. SGTC_1097 itavastatin 7.23 µM 0.167793508640584 0.455101824858408 no 1502 0.43337286472558 485 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1977 st070720 65.3 µM 0.16730710229735 0.4552128419731 no 1503 0.433564208040821 442 682188 SGTC_2665 lovastatin 100 µM 0.166608478411432 0.455372301619914 no 1504 0.433839061070715 455 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_169 k015-0017 16.025 µM 0.163763835734954 0.456021660174144 no 1505 0.434958531081054 472 1840002 SGTC_370 0180-0345 38.7 µM 0.162244301301433 0.4563685789453 no 1506 0.435556737264654 437 3989527 SGTC_2546 rhodinyl acetate 100 µM 0.161869152839983 0.456454232705614 no 1507 0.435704447445224 464 6708682 SGTC_3336 9143619 71.43 µM 0.161217756328275 0.456602964125067 no 1508 0.435960948260604 489 45595730 SGTC_1787 fluconazole 80 µM 0.15885320028479 0.457142907082279 no 1509 0.436892266576624 471 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1990 st072050 59.8 µM 0.158555521019695 0.457210887340585 no 1510 0.437009537230164 485 17233948 SGTC_717 1532-0246 73.2 µM 0.158404206762929 0.457245443073494 no 1511 0.437069149556896 452 9561992 SGTC_1252 0493-0875 34.8 µM 0.155333121533052 0.457946858256823 no 1512 0.438279352647256 458 3960963 SGTC_347 4534-1311 26.2 µM 0.155322905892689 0.457949191660071 no 1513 0.438283379229693 467 2862016 SGTC_1704 st028805 70.8 µM 0.153763736506324 0.458305345936599 no 1514 0.438898013902081 454 2876101 SGTC_338 4055-0136 114 µM 0.153460725159815 0.458374565393666 no 1515 0.439017480086573 446 2900563 SGTC_1857 st056007 79.3 µM 0.153028946044716 0.45847320254689 no 1516 0.439187724242706 461 619834 SGTC_2818 7996756 12.99 µM 0.152540606451526 0.45858476365761 no 1517 0.439380282918131 491 2241621 SGTC_691 1548-0686 185 µM 0.148585979345998 0.459488317072763 no 1518 0.440940168525266 492 46495133 SGTC_3132 9126706 49.47 µM 0.148129759054475 0.459592567863035 no 1519 0.441120182091847 501 850858 SGTC_1027 k015-0025 8.67 µM 0.147898028248404 0.459645521678873 no 1520 0.44121162216208 436 3598955 SGTC_1720 st037298 9.481 µM 0.147573037898958 0.459719787844985 no 1521 0.441339867362087 481 597396 SGTC_1031 k035-0009 16 µM 0.144748626675358 0.460365275741938 no 1522 0.442454672442116 493 5180959 SGTC_1563 conessine 56.1 µM 0.144555456285821 0.460409426530398 no 1523 0.442530934230515 490 441082 An anti-amoebic, histamine inhibitor. SGTC_83 0170-0301 39.027 µM 0.143295292534768 0.460697459973116 no 1524 0.44302848674011 465 3089716 SGTC_1692 fluoroquinolonic acid 71 µM 0.142682899886436 0.460837440953685 no 1525 0.44327031121913 483 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_397 arbidol 50 µM 0.138528785104993 0.461787117570524 no 1526 0.444911260849443 490 131410 A RNA synthesis inhibitor. SGTC_307 1501-1223 22.3 µM 0.138398405703735 0.461816927299997 no 1527 0.444962778478129 485 2830329 SGTC_3007 9078383 71.4286 µM 0.136137110148915 0.462333980133236 no 1528 0.445856445477117 460 6496995 SGTC_60 0986-0278 202 µM 0.1333388775152 0.46297389346329 no 1529 0.446962691142038 490 3110598 SGTC_1337 1486-1011 40.3 µM 0.132764096736214 0.463105349020734 no 1530 0.447189974796907 499 X1337 SGTC_2030 5175110 200 µM 0.132704331903811 0.463119017801428 no 1531 0.4472136084029 496 2831986 SGTC_1014 4130-3005 69.3 µM 0.132576203712923 0.463148322073527 no 1532 0.447264276476483 464 743608 SGTC_1913 st060213 96.1 µM 0.130919348971312 0.463527280228759 no 1533 0.447919554078823 474 688959 SGTC_1911 st060208 74.3 µM 0.130411776172187 0.463643379634396 no 1534 0.448120325059494 467 688783 SGTC_2569 tetrandrine 100 µM 0.129517995237741 0.463847825681646 no 1535 0.448473893368781 441 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_835 0312-0010 67.2 µM 0.129089560097435 0.463945830568583 no 1536 0.448643391362093 492 1626196 SGTC_767 0929-0023 86 µM 0.128205870692867 0.464147982142393 no 1537 0.448993027135792 494 1204563 SGTC_1496 4469-0713 57.4 µM 0.128148267249209 0.4641611597489 no 1538 0.449015819581165 492 746691 SGTC_2138 5575593 77.673 µM 0.126610182979295 0.464513032881851 no 1539 0.449624468477635 495 762213 SGTC_309 k408-0051 1.48 µM 0.125942678664101 0.464665748924595 no 1540 0.449888649467255 509 3640463 SGTC_2365 9042475 200 µM 0.125756743317635 0.464708289368188 no 1541 0.449962241841101 492 6464479 SGTC_2211 7117706 200 µM 0.125623375774711 0.464738802988889 no 1542 0.450015029174701 505 822771 SGTC_3272 9137413 49.47 µM 0.124898209799451 0.46490471984105 no 1543 0.450302067823693 473 17614870 SGTC_1558 st069300 45.6 µM 0.12430164059164 0.465041218528034 no 1544 0.450538224186401 495 24208000 SGTC_1425 4048-4433 7.33 µM 0.123581745962036 0.465205940302295 no 1545 0.450823223145334 505 23734946 SGTC_2012 4023501 200 µM 0.121788264158346 0.465616339429586 no 1546 0.451533354302073 494 3477460 SGTC_463 ikarugamyin 104 µM 0.120729795577516 0.465858564027744 no 1547 0.451952529074972 510 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2227 7312221 64.1025 µM 0.119804723943025 0.466070271843999 no 1548 0.452318919867154 508 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1278 0874-0585 172 µM 0.118825904189106 0.466294290671499 no 1549 0.452706642751364 476 766306 SGTC_1739 st037196 92.5 µM 0.118099135941728 0.466460630322833 no 1550 0.452994554040277 483 612214 SGTC_899 1083-0020 478 µM 0.117626766211916 0.466568747457586 no 1551 0.453181697900076 501 767123 SGTC_1048 3161-0300 24.5 µM 0.117332266458214 0.466636154527786 no 1552 0.453298378339566 468 2165101 SGTC_3051 9093778 49.47 µM 0.113070622730318 0.467611694156318 no 1553 0.454987282632287 502 17217378 SGTC_1390 3413-2614 145 µM 0.112514144973139 0.467739092849061 no 1554 0.455207877445402 503 3421432 SGTC_1465 k213-0056 144 µM 0.111089919543454 0.468065166648131 no 1555 0.455772521151149 489 24048857 YMR208W ERG12 SGTC_21 0849-0113 22.993 µM 0.110136626599252 0.468283433302992 no 1556 0.456150510504442 486 1560156 SGTC_300 r073-0011 5.04 µM 0.108999452270831 0.468543814039988 no 1557 0.456601462386018 491 2735780 SGTC_1518 st038567 90.8 µM 0.107020621064575 0.468996942397604 no 1558 0.457386310231083 508 77966 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.104963413775938 0.469468060499535 no 1559 0.458202419941889 484 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_3241 9133421 49.47 µM 0.104205918560126 0.469641544200077 no 1560 0.45850296860717 505 17018221 SGTC_2891 9063876 19.48 µM 0.103978692545698 0.469693585270901 no 1561 0.458593128893097 512 6472478 SGTC_1669 st015249 58.4 µM 0.0968918696945886 0.471316920003935 no 1562 0.461406132736005 517 722793 SGTC_3354 9151612 71.43 µM 0.0964248691992427 0.47142390995837 no 1563 0.461591570691796 506 27261949 SGTC_1064 honokiol 6.76 µM 0.0962694382242611 0.471459519699466 no 1564 0.46165329154314 509 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2975 9084847 53.72 µM 0.0957937921280647 0.471568493180961 no 1565 0.461842173925204 477 27211724 SGTC_460 trequinsin 123 µM 0.0957607044805107 0.471576073846265 no 1566 0.461855313581467 507 5537 A vasodilator. SGTC_1176 0848-0131 83.3 µM 0.095172516274111 0.471710834551252 no 1567 0.462088899855605 515 6769040 SGTC_681 1642-0006 26.6 µM 0.0949094208039139 0.471771113808543 no 1568 0.462193386790844 512 4446530 SGTC_1021 4476-0760 85.3 µM 0.0931883176748307 0.472165461147665 no 1569 0.462876977573698 486 746768 SGTC_2553 4-methylesculetin 85.09 µM 0.0923265816911508 0.47236291647266 no 1570 0.463219284713693 463 5319502 SGTC_1424 4048-1941 275 µM 0.0922986960167131 0.472369306217323 no 1571 0.463230362188513 516 X1424 SGTC_1852 st056254 31.4 µM 0.0897231074429947 0.472959508987594 no 1572 0.464253626457312 503 442583 SGTC_2659 sanguinarine 24.21 µM 0.0895074397732563 0.473008932502598 no 1573 0.464339320616841 510 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1954 st077032 68.9 µM 0.0888232599658931 0.473165725420721 no 1574 0.464611185985876 513 698907 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0887994002327491 0.47317119341111 no 1575 0.464620667177176 496 688761 SGTC_792 4534-1957 155 µM 0.0878352272164552 0.473392159396183 no 1576 0.465003819343123 499 1717904 SGTC_1811 st050069 61.5 µM 0.087154481263771 0.473548175438615 no 1577 0.465274360154033 519 3877702 SGTC_1523 st012844 44.7 µM 0.0867086780396745 0.473650348579973 no 1578 0.46545153916128 460 4274103 SGTC_3253 9135987 49.47 µM 0.0856024053716578 0.473903901446637 no 1579 0.465891243135432 497 4182430 SGTC_1413 3910-0535 34.4 µM 0.0852613866766336 0.473982063579488 no 1580 0.466026794339326 515 2876951 SGTC_1185 1319-0113 81.3 µM 0.085195710525866 0.473997116793144 no 1581 0.466052900344508 511 4672763 SGTC_2724 maprotiline 69.64 µM 0.0837382717813311 0.474331176591806 no 1582 0.466632263754738 517 4011 A tricyclic antidepressant. SGTC_1150 3909-7983 10.9 µM 0.0804783297209008 0.475078453489273 no 1583 0.467928415350075 522 23965914 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.076627174380841 0.475961367045195 no 1584 0.469460070237774 501 23847180 SGTC_2413 inermin 26.06 µM 0.0739661295054748 0.47657150581357 no 1585 0.470518668074033 513 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3124 9127567 49.47 µM 0.0719946541282353 0.477023571859305 no 1586 0.471303081100265 504 17592030 SGTC_3271 9137798 49.47 µM 0.0718158458606473 0.477064574677829 no 1587 0.471374231104493 522 6498326 SGTC_292 k038-0015 474 µM 0.0715027699263088 0.4771363672208 no 1588 0.47149881006021 498 46368540 SGTC_3138 9097216 49.47 µM 0.0701007558759827 0.477457877059999 no 1589 0.472056732541139 522 25237486 SGTC_2335 9018011 154.17 µM 0.070013094424604 0.477477980072157 no 1590 0.472091618685193 513 6458208 SGTC_1712 st032288 53.4 µM 0.0699239487264715 0.477498423518819 no 1591 0.472127095726316 513 2883011 SGTC_1445 4239-0156 97.7 µM 0.067999291729831 0.477939812197376 no 1592 0.472893099049379 522 4008346 SGTC_991 3996-0057 64.7 µM 0.0669482802747011 0.478180855983831 no 1593 0.47331143856249 502 715343 SGTC_3295 9122362 53.5725 µM 0.0654059467953068 0.478534596241976 no 1594 0.473925394681311 507 4730473 SGTC_429 1112-0049 25.5 µM 0.0649410588362932 0.478641223455779 no 1595 0.474110464674167 504 2836170 SGTC_645 0845-0943 5.41 µM 0.0630866999828645 0.479066556377768 no 1596 0.474848732539166 507 1885106 SGTC_2484 5809818 12.04 µM 0.0630387677458811 0.479077550877753 no 1597 0.474867816749259 513 2870548 SGTC_402 epigallocatechin gallate 10 µM 0.0628539717443707 0.479119938775801 no 1598 0.474941393777798 513 65064 An antioxidant. SGTC_1281 0884-0031 11.8 µM 0.0619925007603383 0.479317543260887 no 1599 0.475284402021307 515 1548255 SGTC_2977 9011197 71.43 µM 0.0601388385002832 0.479742754067176 no 1600 0.476022528638157 540 2704722 SGTC_2499 avocadenofuran 51.48 µM 0.0594940938690037 0.479890657195419 no 1601 0.476279284778103 494 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1886 st057356 49.9 µM 0.0594398199355158 0.479903107653782 no 1602 0.476300898694235 510 24207747 SGTC_1305 1181-0477 144 µM 0.058978903180863 0.480008842899422 no 1603 0.476484455839036 518 6252086 SGTC_2153 5569715 200 µM 0.0571512161126664 0.480428131824451 no 1604 0.4772123692512 526 2054701 SGTC_2240 6690706 185.951 µM 0.0548658002201264 0.480952458542128 no 1605 0.478122689145545 522 805876 SGTC_428 3448-4153 16.5 µM 0.0548289082338316 0.48096092268093 no 1606 0.478137384798085 520 3834874 SGTC_729 4092-0585 94.1 µM 0.0538672874172912 0.481181550632095 no 1607 0.478520449834208 505 2169061 SGTC_506 n9-isopropylolomoucine 153 µM 0.0538060516543446 0.48119560035845 no 1608 0.478544843991634 532 6610355 SGTC_2208 7283366 200 µM 0.0537414257280903 0.481210427937742 no 1609 0.478570588757127 527 898663 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.0530654145202307 0.481365531482266 no 1610 0.478839893911829 517 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2703 st077852 53.4 µM 0.0512447266865167 0.481783282804802 no 1611 0.479565255949587 507 6281836 SGTC_626 0214-0009 33 µM 0.0504614271605866 0.481963014695451 no 1612 0.479877343445069 511 3437874 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.0497754628013879 0.482120415570342 no 1613 0.480150660143361 514 15053 SGTC_1637 st007924 17.4 µM 0.0496565271698508 0.482147706736647 no 1614 0.48019804999292 527 683336 SGTC_3003 9075612 71.4286 µM 0.0450865242814806 0.483196409298041 no 1615 0.482019171282856 526 6501993 SGTC_3118 9124250 49.47 µM 0.0450580130189989 0.48320295229964 no 1616 0.482030534083246 526 1504786 SGTC_389 tpck 16.7 µM 0.0430235003786992 0.483669860750053 no 1617 0.482841400301031 503 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1226 3909-7979 35.4 µM 0.0430170746206649 0.483671335458801 no 1618 0.482843961436494 529 6615510 SGTC_2385 9074692 200 µM 0.042893120192861 0.483699782991192 no 1619 0.482893366497887 526 17046906 SGTC_2458 5808907 16.39 µM 0.0387794752467346 0.484643910403741 no 1620 0.484533104451974 530 2731747 SGTC_2737 bleomycin 30.5 nM 0.0386544709066536 0.484672601669173 no 1621 0.484582936605134 532 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0378625776491312 0.484854360553159 no 1622 0.484898625175321 531 115019 SGTC_124 0136-0217 7.121 µM 0.0377948475122486 0.484869906423872 no 1623 0.484925626264228 526 3976905 SGTC_3042 9091578 49.47 µM 0.0371066184280715 0.485027874632781 no 1624 0.485199997460938 533 25236497 SGTC_2058 5236698 133 µM 0.0360245695881399 0.485276240452407 no 1625 0.485631383984103 524 766665 SGTC_1065 prochlorperazine maleate 2.48 µM 0.035643705084086 0.485363662754611 no 1626 0.485783229414403 534 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_521 r062-0005 13.8 µM 0.0331629388147775 0.485933106166719 no 1627 0.48677232619849 533 2832033 SGTC_1039 k821-0043 94 µM 0.0305479308714301 0.486533394896195 no 1628 0.487815033945884 527 15992768 SGTC_3335 9143315 29.6265 µM 0.0301525418995747 0.486624161188676 no 1629 0.487972698690808 529 4899691 SGTC_1457 k015-0032 57.3 µM 0.0299348794649181 0.486674128513653 no 1630 0.48805949425793 530 4302660 SGTC_983 1491-0821 12.2 µM 0.0295081266214463 0.486772095946804 no 1631 0.488229668829217 527 46495113 SGTC_1925 st057770 10.1 µM 0.0286907929443256 0.486959729216261 no 1632 0.48855559975627 510 5989122 SGTC_502 l-744,832 89.3 µM 0.0286215724412452 0.486975620129013 no 1633 0.488583203405549 538 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1873 rapamycin 2 nM 0.0282962532973909 0.487050303742182 no 1634 0.488712934420241 535 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2360 9040895 200 µM 0.027430353132976 0.487249090908019 no 1635 0.489058244526519 526 4914414 SGTC_3136 9095672 49.47 µM 0.026854104117765 0.487381383793708 no 1636 0.48928804995506 535 17217380 SGTC_1221 2958-7315 257 µM 0.0260348680188003 0.487569463044312 no 1637 0.489614763606261 537 4562705 SGTC_1052 3253-3998 198 µM 0.0251188851545089 0.487779756574098 no 1638 0.48998006837972 530 5450317 SGTC_908 3448-7491 47.7 µM 0.0249468832714692 0.487819245557157 no 1639 0.490048665706625 540 1203031 SGTC_3061 glucosamine 200 µM 0.0233121521673496 0.488194560545727 no 1640 0.490700639160508 536 91431 and experimental redox chemotherapeutic SGTC_834 0312-0008 75.7 µM 0.0229660996169472 0.488274011483487 no 1641 0.490838657199719 541 6385573 YIL048W NEO1 SGTC_2200 6600604 21.907 µM 0.0229118322764513 0.488286470879384 no 1642 0.490860301041083 534 2904777 SGTC_2762 leflunomide 42.06 µM 0.0217519307715491 0.488552778739383 no 1643 0.491322919395301 542 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2217 6934799 96.0675 µM 0.0194907433841626 0.489071951156877 no 1644 0.492224810675637 528 675606 SGTC_2057 5236571 38.335 µM 0.0121834817833816 0.490749832817453 no 1645 0.495139614238104 541 54684039 YBR257W POP4 SGTC_1942 st076330 65.2 µM 0.0114633048387737 0.4909152080344 no 1646 0.49542690318333 539 24208414 SGTC_115 0527-0192 112.043 µM 0.00990429398493125 0.491273211141069 no 1647 0.496048822970469 545 4233931 SGTC_1956 st077085 54 µM 0.00940039068731855 0.491388926378687 no 1648 0.496249841934537 544 24208685 SGTC_66 0109-0187 42.4 µM 0.00932943196920062 0.491405221240047 no 1649 0.496278149126031 541 759417 SGTC_2985 9022375 71.43 µM 0.00714988559222566 0.491905736094645 no 1650 0.497147632639829 536 4939335 SGTC_2706 st078239 82.5 µM 0.00588969883684741 0.49219513345761 no 1651 0.497650363699405 545 15434492 SGTC_1840 st055363 71 µM 0.00506481138092817 0.492384568133818 no 1652 0.497979441236561 545 676033 SGTC_791 1348-1292 225 µM 0.00451286907091199 0.492511322159886 no 1653 0.498199631832745 544 5437054 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0030604886472484 0.492844866152524 no 1654 0.498779043585957 546 66535 A nucleotide analog. SGTC_1190 1486-1332 13 µM 0.00101870167691216 0.493313777724646 no 1655 0.499593596900255 548 4150046 SGTC_1428 4049-0204 61.7 µM -0.000926637937250284 0.493760548048004 no 1656 0.499630325001111 548 X1428 SGTC_414 piperonyl butoxide 100 µM -0.00207341623842604 0.494023922993835 no 1657 0.499172827190298 551 5794 A potent inhibitor of cytochrome P450. SGTC_1207 2099-0101 141 µM -0.00277365954550089 0.494184745726786 no 1658 0.49889347135465 550 5837381 SGTC_797 k781-0471 270 µM -0.00621341635281425 0.494974757354201 no 1659 0.497521221460647 554 23738129 SGTC_1391 3442-0225 151 µM -0.00696608746131606 0.495147626650142 no 1660 0.497220955658883 550 5227075 SGTC_1293 1000-1278 195 µM -0.00851125419896718 0.495502514735188 no 1661 0.496604541836155 553 678847 SGTC_2635 hydroquinidine 100 µM -0.00879468254028523 0.495567611885292 no 1662 0.49649147452069 551 442912 An experimental heart treatment. SGTC_2969 9091408 28.7 µM -0.0100141760143621 0.495847703582561 no 1663 0.496004988557036 561 4286311 SGTC_2712 st079126 47.7 µM -0.0110643153146559 0.496088899875769 no 1664 0.495586066875742 556 3152970 SGTC_2774 tamoxifen 10.92 µM -0.0117686531366909 0.49625067319355 no 1665 0.495305095055637 552 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2184 6075246 200 µM -0.0117906494477019 0.496255725347772 no 1666 0.49529632040597 551 2267320 SGTC_3223 9129970 49.47 µM -0.0120067534826695 0.496305360562137 no 1667 0.495210113472389 554 17248386 SGTC_232 clozapine 119 µM -0.0122509024511102 0.496361437262643 no 1668 0.495112719290422 557 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3113 9123498 49.47 µM -0.0123904593740672 0.496393491052277 no 1669 0.495057048358938 550 8897275 SGTC_1367 1812-0510 76.9 µM -0.0147632418770377 0.496938481177432 no 1670 0.494110532558388 555 1142582 YDR527W RBA50 SGTC_1330 1469-0054 61.8 µM -0.015514300139073 0.497110988465852 no 1671 0.493810938002523 554 7102664 SGTC_174 3553-0389 74.3 µM -0.0172224300786886 0.497503323323751 no 1672 0.493129584113444 555 738071 SGTC_1125 tnp00248 1.32998 µM -0.0209505387663413 0.498359628453881 no 1673 0.491642555675368 562 24207736 SGTC_321 4534-3890 65.3 µM -0.0221855078183762 0.49864328897963 no 1674 0.491149988916154 561 699746 SGTC_2179 6298986 200 µM -0.0230791766885262 0.498848556568795 no 1675 0.490793557928781 557 738374 SGTC_2920 7982904 15.77 µM -0.0280921721037598 0.5 no 1676 0.488794318683715 556 6456808 SGTC_1967 st070177 51.4 µM -0.0292789270648069 0.499727411880112 no 1677 0.488321066731327 558 5729214 SGTC_1846 st056244 14.8 µM -0.0298699893401094 0.499591649643817 no 1678 0.488085370101191 578 5393182 SGTC_906 1165-0455 526 µM -0.029925402732516 0.499578921636805 no 1679 0.488063273234158 580 3252859 SGTC_1458 k015-0034 6.33 µM -0.0322498967657169 0.499045004746907 no 1680 0.487136382493637 581 3598957 SGTC_2771 fluoxetine 41.05 µM -0.0325438048087167 0.498977496623015 no 1681 0.487019191664461 562 3386 A selective serotonin reuptake inhibitor. SGTC_1813 st051246 8.6015 µM -0.033815937914213 0.498685299063821 no 1682 0.486511963298257 563 5291959 SGTC_1385 3091-4834 14.1 µM -0.0345897707284329 0.498507556945156 no 1683 0.486203429198217 561 4072814 SGTC_2412 st077135 33.4 µM -0.0355742164612956 0.498281439452924 no 1684 0.485810933793916 612 13258915 SGTC_2596 sinensetin 100 µM -0.0361707392120181 0.498144424314284 no 1685 0.485573108720969 567 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2783 7738165 71.43 µM -0.036816212988387 0.49799616587573 no 1686 0.48531577335846 565 17201110 SGTC_2972 9093619 59.92 µM -0.0370514619409515 0.497942131769412 no 1687 0.485221986594552 566 25236256 SGTC_441 propafenone 146 µM -0.0393289298407735 0.49741902445169 no 1688 0.484314070888075 565 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1024 4507-0395 26 µM -0.0395972771494383 0.497357388537982 no 1689 0.48420709912909 561 4201836 SGTC_315 k915-0449 187 µM -0.0404949586648807 0.497151203145517 no 1690 0.483849263074648 574 20970215 YNL149C PGA2 SGTC_1132 3456-3614 2.5 µM -0.0410293631959468 0.497028457957093 no 1691 0.48363624356012 600 3125502 SGTC_2116 5511452 16.8835 µM -0.0427522210621274 0.496632743762679 no 1692 0.482949525602995 586 870744 SGTC_3143 9086658 49.47 µM -0.0429095475935697 0.496596608415373 no 1693 0.48288681894143 577 25236626 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.0433147504578906 0.496503540032334 no 1694 0.482725316546389 575 442882 SGTC_285 1486-1325 46 µM -0.0453762946477548 0.49603004054904 no 1695 0.481903687825658 569 22310230 SGTC_1841 st054148 70 µM -0.0467968210819955 0.495703774486289 no 1696 0.481337581334336 590 675442 SGTC_2935 9038016 29.96 µM -0.0469077981866367 0.495678285418145 no 1697 0.4812933564417 567 6463195 SGTC_2383 9036125 200 µM -0.0475009154106585 0.495542059374851 no 1698 0.481057000384356 565 79580 SGTC_1856 st057054 55.7 µM -0.048707088902055 0.495265029346843 no 1699 0.48057636322806 574 1266018 SGTC_252 miconazole 1.30953 nM -0.0491068460966463 0.495173214904019 no 1700 0.480417073797777 580 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2959 9079155 11 µM -0.0508176273307272 0.494780293277504 no 1701 0.479735422223046 568 16189457 SGTC_3312 9133330 71.43 µM -0.0526060608776017 0.494369542369268 no 1702 0.479022893888816 600 17617324 SGTC_955 1216-0110 33 µM -0.0534833338252764 0.494168060571858 no 1703 0.478673404661653 568 3619719 SGTC_1007 4101-0031 70 µM -0.056005156415035 0.493588886297492 no 1704 0.477668849692749 607 1146276 SGTC_734 2023-0417 80 µM -0.056187580876721 0.493546990301032 no 1705 0.477596187279227 569 3935732 SGTC_2735 sertaconazole 140 nM -0.056714225534795 0.493426040350708 no 1706 0.477386420958845 575 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_585 0kpi-0023 191 µM -0.0577956118301945 0.493177689565205 no 1707 0.476955716795178 568 64601 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0578665596248843 0.493161395811725 no 1708 0.476927460011191 599 689007 SGTC_3034 9090421 49.47 µM -0.058963452962276 0.492909486565999 no 1709 0.476490608876265 574 17173761 SGTC_2863 9028737 58.44 µM -0.0596956523279371 0.492741333415473 no 1710 0.476199017250654 602 6460917 SGTC_2118 5526350 200 µM -0.0630284446126096 0.491975958179096 no 1711 0.474871926910153 592 743594 SGTC_655 k060-0012 42 µM -0.0649987872375022 0.491523483012053 no 1712 0.474087482929386 577 5994525 SGTC_1854 st056233 32.9 µM -0.0668033225840993 0.491109093861514 no 1713 0.473369139140467 598 5393174 SGTC_146 3448-8650 53.125 µM -0.0673181889037581 0.490990862939947 no 1714 0.473164198541337 604 2891488 YIL048W NEO1 SGTC_3232 9132874 49.47 µM -0.0701964632373159 0.490329927555229 no 1715 0.472018644655508 588 3784940 SGTC_1380 2291-0730 164 µM -0.0705591832906784 0.490246638342303 no 1716 0.471874298210789 578 2999191 SGTC_2788 5282734 71.43 µM -0.0706360387338627 0.490228990546017 no 1717 0.471843713637182 583 743706 SGTC_2636 apigenin dimethyl ether 100 µM -0.0714188896087381 0.490049230883276 no 1718 0.47153218813141 598 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_537 1334-0398 209 µM -0.07150365943143 0.490029766000762 no 1719 0.471498456105001 602 5846986 SGTC_773 4358-1457 44.6 µM -0.0717137296590806 0.489981529688733 no 1720 0.471414864804424 605 1186886 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.0729636441125737 0.489694527466732 no 1721 0.470917524081715 589 4213774 SGTC_3157 9099274 49.47 µM -0.0760742361713893 0.488980304602448 no 1722 0.469680018643042 572 17217662 SGTC_975 1335-0046 28.5 µM -0.0771657656495229 0.488729686839548 no 1723 0.469245837734244 601 16486740 SGTC_1184 1269-1718 139 µM -0.0787696271490252 0.488361444528022 no 1724 0.468607931491769 573 5403821 SGTC_701 4424-0219 185 µM -0.0788147918440319 0.488351074976978 no 1725 0.468589969228749 600 2911779 SGTC_358 0075-0058 9.45 µM -0.0789740518813699 0.488314509862438 no 1726 0.46852663109212 635 1069125 SGTC_2781 5567276 71.43 µM -0.0815419263079001 0.487724955630476 no 1727 0.467505491749262 597 2853274 SGTC_612 0302-0167 22.4 µM -0.0821695000268658 0.487580876001412 no 1728 0.467255963429169 585 235821 SGTC_2407 paclitaxel 400 µM -0.0823984908234751 0.487528304239149 no 1729 0.467164918059511 671 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1946 st076057 65.1 µM -0.0834546834073268 0.487285826110481 no 1730 0.466745004520781 582 953009 SGTC_2022 5136654 200 µM -0.0837108234786969 0.487227022799584 no 1731 0.466643175730698 584 1713771 SGTC_1604 st002052 72.4 µM -0.0839945720555644 0.487161881595256 no 1732 0.466530373695737 579 6254834 YHR062C RPP1 SGTC_2127 5253358 187.912 µM -0.0844429784904507 0.487058939979929 no 1733 0.466352118697537 590 20612 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.085473414231162 0.486822383942313 no 1734 0.465942515239441 586 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1235 benzylparaben 21.5 µM -0.0860368325431655 0.486693042554691 no 1735 0.465718568816342 605 7180 SGTC_2846 9008642 19.48 µM -0.0863087176519865 0.486630627622728 no 1736 0.465610504326922 616 2992898 SGTC_3001 9076041 71.4286 µM -0.0871958715173432 0.486426971648523 no 1737 0.465257910455625 601 16004211 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.0874997986704802 0.486357202623054 no 1738 0.46513712272826 581 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_832 4083-0019 164 µM -0.087709512874781 0.486309061213019 no 1739 0.465053779292662 588 1990758 SGTC_2198 6589944 200 µM -0.0877983683794747 0.486288663850389 no 1740 0.465018467301578 583 5290268 SGTC_382 3229-0966 23.2 µM -0.0879440218312595 0.486255228224901 no 1741 0.464960583882333 601 5722370 SGTC_2746 daunorubicin 9.88 µM -0.0881887955839479 0.486199039156202 no 1742 0.464863311224224 581 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1702 st027038 51 µM -0.0885079297602378 0.486125780683039 no 1743 0.464736491019105 590 5521182 SGTC_2906 7926292 26.41 µM -0.0899213191193199 0.485801337401972 no 1744 0.464174869786553 615 2966319 SGTC_1255 0566-0045 221 µM -0.0922631376939162 0.485263794146467 no 1745 0.463244487634164 609 2788469 SGTC_2204 7233102 200 µM -0.0932803577362693 0.485030308778163 no 1746 0.462840418146527 605 2172480 SGTC_683 panaxydol 45 µM -0.0952458945575399 0.484579168210701 no 1747 0.462059758535675 586 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1799 st045822 46.1415 µM -0.0957447946084333 0.484464661109735 no 1748 0.461861631671637 588 3674992 SGTC_2213 7173844 200 µM -0.0995355290711732 0.483594657596101 no 1749 0.460356539916628 591 892728 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.0995528865509575 0.483590674093803 no 1750 0.460349649507473 609 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1657 st012939 43.4 µM -0.101400860989584 0.483166577595438 no 1751 0.459616126513744 596 24207257 SGTC_2958 9077254 16.72 µM -0.107939162693825 0.481666241745691 no 1752 0.457021975624159 598 16457351 SGTC_1285 0929-0069 65.5 µM -0.108054177758188 0.481639851645376 no 1753 0.45697635805458 595 1206237 SGTC_1612 st002233 45.4 µM -0.109169568904016 0.481383930367638 no 1754 0.456533998257332 581 1035021 SGTC_1074 carmofur 3.8 µM -0.109235579310517 0.481368784828247 no 1755 0.456507820469216 602 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3127 9126946 49.47 µM -0.110458010139103 0.481088313113223 no 1756 0.456023074546034 608 27243249 SGTC_934 2950-0684 338 µM -0.110949728743533 0.480975496960917 no 1757 0.455828105580626 635 1121253 SGTC_54 0159-0055 9 µM -0.113714625057927 0.480341168946473 no 1758 0.454732009304048 649 3319099 SGTC_619 1652-1634 108 µM -0.118690088154193 0.479199814762256 no 1759 0.452760444771786 607 5400454 SGTC_3330 9141424 71.43 µM -0.119822182514212 0.478940139675465 no 1760 0.452312004717903 601 27261020 SGTC_512 prima-1 270 µM -0.122366486410787 0.478356570636931 no 1761 0.451304389491792 597 322968 A re-activator of the apoptotic function of mutant p53. SGTC_751 0833-0568 350 µM -0.1225302077928 0.478319020593921 no 1762 0.451239561935801 595 6954252 SGTC_1498 4478-3555 97.6 µM -0.123399422048081 0.478119666647317 no 1763 0.450895407357611 602 3437919 SGTC_291 SEC14.278 35.5 µM -0.124094403413503 0.477960276881323 no 1764 0.450620264669039 602 1068044 SGTC_2418 pentamidine 31.67 µM -0.124587176840672 0.4778472644154 no 1765 0.450425190346063 622 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1609 st001574 46.4 µM -0.125552536753704 0.477625874320292 no 1766 0.450043067863304 612 3960012 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.126020862938961 0.477518473567277 no 1767 0.449857704997443 606 688662 SGTC_1866 st057638 64 µM -0.130145893107056 0.476572556127455 no 1768 0.448225500706785 609 688802 SGTC_2768 sulfasalazine 50.2 µM -0.130661354084709 0.476454364092839 no 1769 0.448021602576877 648 5384001 An antioxidant and salicylic acid derivative. SGTC_365 0121-0052 13.6 µM -0.131803545956442 0.476192473910915 no 1770 0.447569840878293 606 3101739 SGTC_2462 5162487 171.77 µM -0.131984660499637 0.476150947573499 no 1771 0.447498212373622 632 2259986 SGTC_803 4488-1585 147 µM -0.139698492435402 0.474382549599164 no 1772 0.444449108794496 639 747204 SGTC_2364 9055074 200 µM -0.141129305506868 0.474054589773083 no 1773 0.443883896448149 624 6470630 SGTC_2433 5607874 27.82 µM -0.141855030034214 0.473888251557218 no 1774 0.443597257921639 598 2252428 SGTC_1758 st042942 75.2445 µM -0.143006074810118 0.473624438025447 no 1775 0.443142691751773 607 669317 SGTC_179 1273-0063 6.77 µM -0.146733186578141 0.472770283169499 no 1776 0.441671311504514 650 3108139 SGTC_1025 k007-0731 70 µM -0.146743205044295 0.47276798737056 no 1777 0.441667357513614 595 6256118 SGTC_3289 9119912 71.43 µM -0.147721366203266 0.472543839526314 no 1778 0.44128133442007 659 17014829 SGTC_162 k030-0015 37.8 µM -0.14858117606339 0.472346819327988 no 1779 0.440942063721691 627 1809920 YMR134W ERG29 SGTC_1248 0469-0687 58.6 µM -0.149561856332051 0.472122110673121 no 1780 0.440555151924937 627 4017482 SGTC_1320 1313-0481 95.3 µM -0.149758822650569 0.472076979766769 no 1781 0.440477448829201 592 6813365 YLR208W SEC13 SGTC_455 paf C-16 10 µM -0.153295546593578 0.471266671532074 no 1782 0.439082606235888 619 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1092 toremifene 6.32 µM -0.154100368801713 0.471082293065837 no 1783 0.438765298746149 657 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1685 st024049 53.0905 µM -0.156422872556627 0.470550260530698 no 1784 0.43784985469489 637 1941139 SGTC_423 5-fluorouracil 457 µM -0.157550110009269 0.470292055078774 no 1785 0.437405659443022 620 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2197 6588183 93.1375 µM -0.160872557101355 0.469531087116647 no 1786 0.43609688850509 621 884136 SGTC_2152 5568786 200 µM -0.16134901361074 0.469421969338747 no 1787 0.435909260827097 638 5399883 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.161536401000898 0.469379054622219 no 1788 0.435835471974552 619 88881 An O-methylated flavonoid and antioxidant. SGTC_582 0987-0078 156 µM -0.162411870672789 0.4691785627532 no 1789 0.435490761749889 607 1625765 SGTC_1719 st032227 49.2 µM -0.162530746374874 0.469151339554216 no 1790 0.435443959024778 608 3125804 SGTC_3341 9147222 25.867 µM -0.163713373824497 0.468880519145205 no 1791 0.43497839440681 651 1939759 SGTC_3067 9117431 49.47 µM -0.164038502120836 0.468806067634464 no 1792 0.434850417009683 634 17150885 SGTC_2255 7941087 197.44 µM -0.164736668362904 0.468646197415652 no 1793 0.434575627042131 628 935561 SGTC_742 0kpi-0133 140 µM -0.166930366863591 0.468143904429365 no 1794 0.433712419539562 645 2728852 SGTC_2298 7976326 193.81 µM -0.168010245346559 0.467896662323009 no 1795 0.433287609515886 625 2235818 SGTC_2620 irigenin 100 µM -0.168029222000239 0.467892317659566 no 1796 0.433280145036998 603 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_156 3474-0145 5.642 µM -0.168992637242303 0.467671750879675 no 1797 0.43290121636846 607 2265471 SGTC_2201 6605497 169.863 µM -0.169191826246667 0.467626149269208 no 1798 0.432822879408762 641 670741 SGTC_2128 5255449 168.493 µM -0.171142077241058 0.467179688393943 no 1799 0.432056025528166 621 736008 SGTC_540 1187-0821 17.3 µM -0.173457968827024 0.466649576977733 no 1800 0.43114573152504 623 847520 SGTC_1634 st006576 41 µM -0.175627935480793 0.466152921683943 no 1801 0.430293127065368 617 3915356 SGTC_371 0195-0006 7.36 µM -0.176225310723706 0.466016205494827 no 1802 0.430058468433534 616 3928593 SGTC_2235 salicylic acid 500 µM -0.176729388504946 0.465900844621078 no 1803 0.429860477762599 618 338 A COX inhibitor and kinase inhibitor. SGTC_976 1348-1067 47.6 µM -0.178815179275703 0.465423530903898 no 1804 0.429041413023152 617 5310671 YGL099W LSG1 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.178851016808709 0.46541533025222 no 1805 0.429027342717699 619 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2623 humulene 100 µM -0.179951968220784 0.46516340828025 no 1806 0.428595138166128 637 6187145 An anti-inflammatory. SGTC_372 0155-0182 15.9 µM -0.180529063099691 0.465031361811152 no 1807 0.428368620073822 623 771486 SGTC_277 nystatin 15.5 µM -0.183616844879116 0.46432490480211 no 1808 0.427157023751481 655 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1452 4194-0072 190 µM -0.185217127840153 0.463958818395407 no 1809 0.426529367720824 643 1343545 SGTC_1683 st010134 710 nM -0.185453062910857 0.46390484762522 no 1810 0.4264368459887 672 3818134 SGTC_2990 9074105 71.4286 µM -0.185876546033253 0.463807976409913 no 1811 0.426270787609177 641 6502001 SGTC_3090 9117696 49.47 µM -0.185940637749698 0.463793315699655 no 1812 0.426245656773848 663 7923821 SGTC_410 α-linolenic acid 100 µM -0.189166767168973 0.463055416124761 no 1813 0.424981056669445 644 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2324 6149169 200 µM -0.189456500591759 0.462989152749461 no 1814 0.42486752256352 656 2888231 SGTC_3175 9106517 49.47 µM -0.191251836071562 0.462578574180591 no 1815 0.42416414687056 650 41468073 SGTC_1378 2093-0007 380 nM -0.192053080426269 0.462395348977556 no 1816 0.423850313533515 628 3618014 SGTC_749 1000-0129 128 µM -0.192625983240706 0.462264344851526 no 1817 0.423625947162667 673 708470 SGTC_2937 9044753 11.33 µM -0.193959767293726 0.461959367967865 no 1818 0.423103692325949 610 6465530 YGL099W LSG1 SGTC_2009 4012297 12.05 µM -0.196365911466054 0.461409246872881 no 1819 0.422161887761274 662 45595307 SGTC_1973 st070275 50.2 µM -0.19802050390475 0.461030997188354 no 1820 0.421514510787609 621 17118334 SGTC_308 4092-1169 104 µM -0.199291485211937 0.460740467215084 no 1821 0.421017369700164 634 2268590 YDL196W YDL196W SGTC_2046 4110841 106 µM -0.199468781091811 0.460699941320121 no 1822 0.420948030859438 661 44119630 YMR134W ERG29 SGTC_664 1222-0054 14.9 µM -0.200715025824939 0.460415089033695 no 1823 0.420460704951445 621 6813991 SGTC_2176 5809774 33.9695 µM -0.201592956065867 0.46021443402411 no 1824 0.420117476209794 647 2870539 SGTC_633 0437-0093 97.7 µM -0.205866871283855 0.459237756618927 no 1825 0.418447452007968 639 2831118 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.206441974359199 0.459106352400937 no 1826 0.418222843051983 630 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1987 st072290 61.9 µM -0.209134823411086 0.458491128065274 no 1827 0.417171495285112 663 54697379 SGTC_1203 3992-3522 103 µM -0.209323920418542 0.458447929555232 no 1828 0.41709768979278 707 5322312 SGTC_2773 thioridazine 9.09 µM -0.212722644580972 0.45767158779047 no 1829 0.415771651580707 629 5452 An antipsychotic. SGTC_2425 5628681 7.85 µM -0.21294352896439 0.457621138598599 no 1830 0.415685504858381 636 5714958 SGTC_2040 5100729 123 µM -0.213352136277912 0.45752781597099 no 1831 0.415526155336237 646 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3342 9147791 14.508 µM -0.214310584683716 0.457308923253068 no 1832 0.41515243220297 634 1838168 SGTC_1258 0671-0043 57.1 µM -0.214999253663448 0.457151651391451 no 1833 0.414883950222314 679 4298767 SGTC_592 k241-0073 46.5 µM -0.216204108428948 0.45687651394185 no 1834 0.414414325609803 655 4230158 SGTC_2373 9071805 200 µM -0.21831074591782 0.456395497518808 no 1835 0.413593501174618 686 10149009 SGTC_15 0266-0086 27.098 µM -0.219097172228788 0.456215946195833 no 1836 0.413287176748264 642 1712902 YIL048W NEO1 SGTC_2479 5617353 43.85 µM -0.219343636086786 0.456159677139866 no 1837 0.413191186362936 649 2731746 SGTC_2589 lobaric acid 100 µM -0.221031436158736 0.455774366774295 no 1838 0.412533977872176 651 73157 A novel microtubule depolymerizer. SGTC_3073 9114972 49.47 µM -0.22215956674905 0.455516847347757 no 1839 0.412094834332118 634 41905075 SGTC_92 0063-0024 660.874 µM -0.223173230879695 0.455285473224557 no 1840 0.411700342608478 638 3594437 SGTC_2931 9014674 55.67 µM -0.223484738859206 0.455214372946905 no 1841 0.411579129708974 646 2996810 SGTC_646 4092-0839 27.3 µM -0.227862722864439 0.454215270831722 no 1842 0.409876481620678 661 877796 SGTC_1682 st012968 530 nM -0.229541427636837 0.453832249176226 no 1843 0.409224062719465 639 24207270 SGTC_3187 9109394 49.47 µM -0.229708293638596 0.453794178537036 no 1844 0.4091592249184 640 17098090 SGTC_1486 3970-0793 4.53 µM -0.229865771657306 0.453758250164641 no 1845 0.409098037210967 657 2844330 SGTC_644 1498-1197 63.3 µM -0.2298805013865 0.453754889618496 no 1846 0.409092314123178 651 6741615 SGTC_1509 1326-1131 80 µM -0.232893307995668 0.45306759623411 no 1847 0.40792212751341 625 768313 SGTC_202 3594-0513 34.79 µM -0.237199371438625 0.452085524501295 no 1848 0.406251061960769 657 708429 SGTC_2239 6685329 187.64 µM -0.238498256767437 0.451789348656972 no 1849 0.405747333624428 653 805680 SGTC_2629 bisabolol 100 µM -0.239628013947107 0.451531759747457 no 1850 0.405309322710076 668 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_312 4092-0653 6.84 µM -0.241820268796255 0.451031975663172 no 1851 0.404459716358315 650 1148278 SGTC_2791 5663188 71.43 µM -0.243483553508051 0.4506528364445 no 1852 0.40381541210886 683 54690634 SGTC_1454 4239-0054 42.6 µM -0.244844386482629 0.450342673383502 no 1853 0.403288462120832 685 1340767 SGTC_784 4579-0127 173 µM -0.244965130319399 0.450315154731915 no 1854 0.403241715426402 696 1948547 SGTC_2103 5378138 10 µM -0.246307355578148 0.450009265137296 no 1855 0.402722158194995 661 244142 SGTC_860 0443-0016 25.1 µM -0.246616388021367 0.449938841658372 no 1856 0.402602560209038 659 5337942 SGTC_2921 7974240 10.71 µM -0.246656293466122 0.449929747969968 no 1857 0.402587117152319 685 2979074 YDR527W RBA50 SGTC_170 4197-0004 226 µM -0.246727602163571 0.449913498145756 no 1858 0.402559521691065 652 218692 SGTC_542 3381-0244 89.3 µM -0.24819607054338 0.44957888231874 no 1859 0.401991353253185 680 1112843 SGTC_930 2810-3379 265 µM -0.248961713621722 0.449404431552508 no 1860 0.401695198593423 698 1015764 SGTC_2279 7948423 32.93 µM -0.249534451057101 0.449273940474554 no 1861 0.401473697719614 639 1247112 SGTC_1755 st041960 45.185 µM -0.250251691529424 0.449110533921288 no 1862 0.401196356290204 690 2257073 SGTC_2271 7849410 118.62 µM -0.250273246228354 0.44910562331811 no 1863 0.401188022322517 681 972430 SGTC_1618 st003135 44.5 µM -0.250379051405044 0.44908151883855 no 1864 0.401147114171964 695 1270615 SGTC_615 k087-0205 167 µM -0.253121607899445 0.448456776887682 no 1865 0.400087120888688 647 9642773 SGTC_2555 cholic acid 100 µM -0.253420497950705 0.448388698782695 no 1866 0.399971644724914 663 6708657 Influences liver metabolism. SGTC_2545 solidagenone 89.61 µM -0.259137837953448 0.447086756718819 no 1867 0.397764445592097 637 6708572 An anti ulcer agent SGTC_303 1348-1668 34.2 µM -0.260363366305495 0.446807755385693 no 1868 0.397291749080246 673 5380509 SGTC_2861 9024595 19.48 µM -0.261467338411998 0.446556449838668 no 1869 0.396866066918082 637 16482810 SGTC_2332 7982454 138.89 µM -0.262334348126846 0.446359100880067 no 1870 0.396531841525452 689 2981748 SGTC_1200 1643-0193 18.4 µM -0.262381350829257 0.446348402492915 no 1871 0.396513724525084 684 5403974 SGTC_3092 9117248 49.47 µM -0.262562243541154 0.446307229474434 no 1872 0.396444002250342 660 17141857 SGTC_2438 5259590 200 µM -0.263161540585912 0.446170827518453 no 1873 0.396213036220671 674 1201127 SGTC_1889 st059080 5.18 µM -0.264126808324501 0.445951142841496 no 1874 0.395841103560261 672 176925 Isolated from Daphnopsis sellowiana. SGTC_2411 st077133 39.94 µM -0.271204227581741 0.444340908531289 no 1875 0.393116980825564 721 1403142 YNL221C POP1 SGTC_1863 st057641 20.1 µM -0.271781907566361 0.444209516599215 no 1876 0.392894858717593 662 3921635 SGTC_2851 9015922 71.43 µM -0.273492762487716 0.44382042275865 no 1877 0.392237227526554 668 2996893 SGTC_1550 gossypolone 36.6 µM -0.273569559370911 0.443802958375178 no 1878 0.392207714968352 663 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_787 4152-0075 138 µM -0.273630343945206 0.443789135429139 no 1879 0.392184356279128 643 9566539 SGTC_1724 st037281 8.293 µM -0.279363843274396 0.442485597104822 no 1880 0.389982807885886 654 574124 YDL195W SEC31 SGTC_2945 9067681 61.76 µM -0.280326691194833 0.442266749710707 no 1881 0.389613437380096 700 16456930 SGTC_933 2914-0560 114 µM -0.28095105515192 0.442124846343112 no 1882 0.389373970330799 668 463887 SGTC_501 nsc-95397 161 µM -0.282458993053095 0.441782157883806 no 1883 0.388795792846734 688 262093 SGTC_433 pimozide 108 µM -0.285264238263735 0.441144764217129 no 1884 0.387720854389152 668 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3307 9126885 69.2785 µM -0.286578998643164 0.44084608335241 no 1885 0.387217348442988 682 24824909 SGTC_2877 9040724 71.43 µM -0.287146510706792 0.440717169109981 no 1886 0.387000070290572 672 6463895 SGTC_2536 dehydroabietamide 32.04 µM -0.289618599936344 0.440155690615309 no 1887 0.386054017947699 683 3983547 SGTC_88 0180-0332 8.668 µM -0.291686485477402 0.43968611011038 no 1888 0.385263171567079 656 3101745 SGTC_2154 5570129 200 µM -0.291998065980864 0.439615362986654 no 1889 0.385144051345434 702 673366 SGTC_3070 9117005 49.47 µM -0.293082488942941 0.439369150160491 no 1890 0.384729550585754 675 8779016 SGTC_1619 st003326 88.7 µM -0.295409958102228 0.43884078919937 no 1891 0.383840363552868 646 2849032 SGTC_1120 ficusin 1.78878 µM -0.296276205676112 0.438644169297442 no 1892 0.383509577889312 689 6199 A DNA cross-linker. SGTC_3184 9108758 49.47 µM -0.299747967748465 0.437856305063728 no 1893 0.382184703473838 684 902885 SGTC_195 4234-0266 16.654 µM -0.30021354399188 0.437750668191736 no 1894 0.382007137343795 682 2303354 SGTC_194 1486-1323 56.904 µM -0.300990096660476 0.437574482231572 no 1895 0.381711023145422 659 5178754 SGTC_2673 kobusone 100 µM -0.301122511626517 0.437544440869964 no 1896 0.381660537719921 670 6710676 An epoxy ketone and protein crosslinker. SGTC_1689 st020265 53.493 µM -0.302369014362742 0.437261660903517 no 1897 0.381185386432435 701 5758320 YPR016C TIF6 SGTC_1572 epiandrosterone 68.9 µM -0.305056405740945 0.43665211204884 no 1898 0.3801615963953 659 441302 A steroid. SGTC_840 0245-0196 390 µM -0.306432385241476 0.436340073189705 no 1899 0.379637726847835 664 3827528 SGTC_1167 k781-0610 148 µM -0.306716841806199 0.436275570258024 no 1900 0.379529454690082 692 4525169 SGTC_1000 4048-0884 8.67 µM -0.307187310543021 0.43616889121327 no 1901 0.379350401810296 698 13040088 SGTC_1751 st044839 27.194 µM -0.308516776429161 0.435867459217284 no 1902 0.378844568336991 665 5291326 SGTC_2521 angolensin 13.4 µM -0.310201391783013 0.435485557123494 no 1903 0.378203906105244 672 821428 A flavenoid. SGTC_1807 st050092 58.9 µM -0.311397060912786 0.435214535560596 no 1904 0.377749393984156 708 5008496 SGTC_965 1291-5240 308 µM -0.312577840179302 0.434946918937959 no 1905 0.377300708023054 709 2834598 SGTC_2291 7917025 104.35 µM -0.313648281122119 0.43470433559073 no 1906 0.376894092748097 678 2964612 SGTC_571 k831-0106 44.2 µM -0.314363126317747 0.434542351040761 no 1907 0.376622629255093 712 4783639 SGTC_144 4161-2749 112.381 µM -0.31489726759306 0.43442132132923 no 1908 0.376419828146093 670 797501 YMR168C CEP3 SGTC_762 1165-0429 115 µM -0.314997964198597 0.434398505429983 no 1909 0.37638159978961 710 5967793 SGTC_637 1181-0519 7.26 µM -0.315511277604027 0.434282201958191 no 1910 0.376186744865198 698 6252091 YGR060W ERG25 SGTC_2173 5763948 167 µM -0.317359835082162 0.433863414090538 no 1911 0.375485290053786 673 2867177 SGTC_2946 9065502 71.43 µM -0.317580094015592 0.433813519706248 no 1912 0.375401737844265 665 16489101 SGTC_3052 9092717 49.47 µM -0.318862414973226 0.4335230615828 no 1913 0.374915423124948 699 25237534 SGTC_143 4032-1194 15.74 µM -0.320134969846681 0.433234851061009 no 1914 0.374433008689577 682 1806963 SGTC_994 3910-0338 138 µM -0.321217972778387 0.432989598564026 no 1915 0.374022606480187 678 3479481 SGTC_2137 5261020 140 µM -0.322043548680202 0.432802659289045 no 1916 0.373709851687422 683 763655 SGTC_2537 larixol 68.93 µM -0.324217742009985 0.43231041789047 no 1917 0.372886595386217 687 6708759 SGTC_2919 7978188 46.38 µM -0.325287845974579 0.432068182897749 no 1918 0.372481614317778 652 2980291 SGTC_394 menadione 8.33 µM -0.331095261796112 0.430754029914453 no 1919 0.370286265264996 711 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1432 4049-0298 68.4 µM -0.33166316524943 0.430625560644653 no 1920 0.370071808792794 705 741646 SGTC_2889 9059656 51.95 µM -0.331665215070291 0.430625096954143 no 1921 0.370071034795342 695 3949838 SGTC_3151 9099821 49.47 µM -0.334875433178695 0.429899030452967 no 1922 0.368859527343717 732 17174189 SGTC_728 3030-5151 22.5 µM -0.335899300337136 0.429667508492237 no 1923 0.368473402342559 685 3125388 SGTC_2036 5160441 105 µM -0.337500308923424 0.429305528934186 no 1924 0.367869889651783 683 134534 YIL048W NEO1 SGTC_1417 3966-0327 90.4 µM -0.337874031342038 0.429221040820921 no 1925 0.367729058949655 705 651118 SGTC_1201 1889-3372 45.9 µM -0.337905159457942 0.42921400377684 no 1926 0.367717329670161 688 5392199 SGTC_2081 5214970 32.255 µM -0.338900293833798 0.428989048463696 no 1927 0.367342421541129 690 2063512 SGTC_3107 9121808 49.47 µM -0.339210317681046 0.428918970665342 no 1928 0.367225648593103 672 662681 SGTC_1459 k035-0031 35.7 µM -0.340809960011802 0.428557423125851 no 1929 0.366623325943093 675 3877128 YMR208W ERG12 SGTC_2695 st077686 51.995 µM -0.341668548641172 0.428363391571415 no 1930 0.366300171862949 681 2876092 SGTC_119 0121-0043 24.815 µM -0.342452483518951 0.428186246062988 no 1931 0.366005198605741 714 1092378 SGTC_1469 k284-2957 126 µM -0.343126178585642 0.428034022968833 no 1932 0.365751768828299 689 23884841 SGTC_136 0097-0015 404.482 µM -0.343721847979673 0.42789943889145 no 1933 0.365527739441916 695 4861337 SGTC_1388 3346-4487 254 µM -0.344697411225461 0.427679040656035 no 1934 0.36516093227124 710 3345614 SGTC_2267 7931562 200 µM -0.344745566859118 0.427668161969145 no 1935 0.365142829172081 683 934880 SGTC_1825 st052143 62.6 µM -0.350987184916941 0.426258606171666 no 1936 0.362798981261245 721 674173 SGTC_1477 0139-0234 16 µM -0.351037019255514 0.426247355758361 no 1937 0.36278028803931 682 620880 SGTC_1316 1272-0050 65.9 µM -0.351978131360738 0.426034905099796 no 1938 0.362427331506326 719 7340392 SGTC_2397 5161689 200 µM -0.35428764162879 0.425513637503672 no 1939 0.361561664227306 723 2259942 SGTC_3109 9122853 49.47 µM -0.354797896071566 0.425398488141285 no 1940 0.361370502333888 715 1234709 SGTC_813 k007-0158 173 µM -0.355359851549524 0.425271678744912 no 1941 0.36116001119051 693 6523916 SGTC_323 4013-0906 34.3 µM -0.356456143502034 0.425024314646936 no 1942 0.360749495158169 709 2910086 SGTC_3057 9095946 49.47 µM -0.35787779650249 0.424703581007543 no 1943 0.360217383777548 697 24540043 SGTC_2206 7254556 146.969 µM -0.359021242378336 0.424445648759402 no 1944 0.359789599060855 680 4398905 SGTC_1433 4060-0023 7.6 µM -0.360645335007045 0.424079350488187 no 1945 0.359182297222634 688 3840627 SGTC_1169 aniline yellow 25.8 µM -0.361417980371111 0.423905110853285 no 1946 0.358893504363461 711 6051 A DNA damaging agent. SGTC_1069 diphenylcyclopropenone 8.49 µM -0.362507778859402 0.423659375156023 no 1947 0.358486305796619 747 65057 A dermal irritant. YDR527W RBA50 SGTC_260 nsc-65238 3.989 µM -0.364704438042921 0.423164146769168 no 1948 0.357666022697503 696 3246252 SGTC_1728 st035614 33.7865 µM -0.365566298569117 0.422969876729318 no 1949 0.357344363376421 717 15945546 SGTC_361 000s-0510 1.45 µM -0.367756837665582 0.422476196651262 no 1950 0.356527277749192 700 660 SGTC_105 0111-0055 734.78 µM -0.368515435429329 0.422305260411657 no 1951 0.356244468957959 726 5179370 SGTC_710 3448-4187 58 µM -0.368592304155716 0.422287940255074 no 1952 0.356215816346084 686 3946412 SGTC_1017 4239-0030 168 µM -0.368729465096024 0.422257035355541 no 1953 0.356164691989695 683 1149593 SGTC_1821 st053465 65.6 µM -0.370177759480316 0.421930737060521 no 1954 0.355625023381924 715 675086 SGTC_2847 9005661 71.43 µM -0.370252572839979 0.421913883189716 no 1955 0.355597154009978 689 2991449 SGTC_3028 9087778 49.47 µM -0.374825641856722 0.4208839399619 no 1956 0.353895071410357 679 17217395 SGTC_12 0849-0099 9.267 µM -0.381753477300715 0.419324691216096 no 1957 0.351322114782771 727 6071388 SGTC_1189 1431-2119 7.28 µM -0.381892248518168 0.419293470814829 no 1958 0.351270645057484 732 3107275 SGTC_35 0133-0054 64.071 µM -0.383986513922294 0.418822370030249 no 1959 0.350494221529761 730 99677 SGTC_2319 6033012 152.6 µM -0.384129363035492 0.418790240642438 no 1960 0.350441284656308 695 847246 SGTC_869 0564-0080 44.1 µM -0.387640510905343 0.418000689832007 no 1961 0.349141042592862 702 6843321 SGTC_1711 st032263 62.8 µM -0.387968427567458 0.417926968125592 no 1962 0.349019699160775 717 3958979 SGTC_478 N-arachidonylglycine 10 µM -0.388236743603654 0.417866647882977 no 1963 0.348920422035865 692 5283389 SGTC_3275 9138069 49.47 µM -0.391010912927101 0.417243099208064 no 1964 0.347894584701663 728 17617007 SGTC_2166 5933061 31.504 µM -0.391914866602889 0.417039962856675 no 1965 0.347560558994885 705 2877375 SGTC_719 2810-4230 27.3 µM -0.391933061337025 0.417035874365581 no 1966 0.347553836956168 707 721079 SGTC_3180 9109287 49.47 µM -0.392123190235173 0.416993151535247 no 1967 0.347483596763434 691 18891271 SGTC_225 nsc-122657 1.016 µM -0.393615834929172 0.416657781559472 no 1968 0.346932344270377 736 275685 SGTC_523 1934-0222 13.7 µM -0.3950996361801 0.416324458654971 no 1969 0.346384678679889 741 1361595 SGTC_2720 fluspirilene 36.88 µM -0.397496842709676 0.415786074507424 no 1970 0.345500557167999 729 3396 An atypical antipsychotic. SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.399056313354532 0.415435920674942 no 1971 0.344925855551851 705 16486 A toxic proline analog. SGTC_2419 paclitaxel 166.5 µM -0.399191665854947 0.415405532629743 no 1972 0.344875991817291 725 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3323 9138564 53.9225 µM -0.401463007798087 0.414895668346123 no 1973 0.344039634112457 699 43912313 YNL103W MET4 SGTC_2978 9011784 42.97 µM -0.401780981788438 0.414824301879399 no 1974 0.343922609890576 699 2994934 SGTC_3245 9134821 49.47 µM -0.401799780037124 0.414820082865724 no 1975 0.343915692024011 734 17014901 SGTC_1828 st055811 49 µM -0.401885364374991 0.414800874738245 no 1976 0.343884197142602 748 5877589 SGTC_2146 5545642 200 µM -0.403120500514338 0.414523689567899 no 1977 0.343429790000249 726 825326 SGTC_2426 5582046 32.21 µM -0.403274075641495 0.414489227717509 no 1978 0.343373305440928 727 2251934 SGTC_314 1671-0008 2.74 µM -0.405966800445075 0.413885094605068 no 1979 0.342383497165931 757 3913060 SGTC_2005 4024620 188 µM -0.407782125527043 0.413477927624939 no 1980 0.341716818761686 735 236743 SGTC_1839 st053978 48 µM -0.408290755199835 0.413363861577856 no 1981 0.341530112837169 713 3788398 SGTC_1736 st036774 51 µM -0.408467183111975 0.413324297299341 no 1982 0.341465359377027 754 1272247 SGTC_453 enantio-paf c16 10 µM -0.408720825036946 0.413267419181056 no 1983 0.341372274618262 751 13871343 A lipid and platelet activating factor SGTC_799 1310-0557 151 µM -0.409634823404809 0.41306247405721 no 1984 0.341036923875429 757 5354492 SGTC_3209 9113616 49.47 µM -0.413475360478638 0.412201573038908 no 1985 0.339629185567996 751 16649353 SGTC_1088 bifonazole 369 nM -0.415137204693967 0.411829182007348 no 1986 0.339020732512618 732 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1648 st011736 69.8 µM -0.416066353135152 0.411621010222925 no 1987 0.338680725062406 715 2855514 SGTC_2483 5729050 27.16 µM -0.416816047126974 0.411453062579533 no 1988 0.338406481966819 749 2865180 SGTC_2276 7947513 42.08 µM -0.417015219101531 0.411408446482627 no 1989 0.338333637921662 743 2105100 SGTC_1999 st074831 12.5 µM -0.417966864269389 0.411195286265342 no 1990 0.337985672088924 772 17112523 SGTC_2941 9056145 11.23 µM -0.419349563204705 0.410885620495955 no 1991 0.337480339568172 753 2119517 SGTC_1779 st039427 55 µM -0.424490923619181 0.409734662962504 no 1992 0.335603911638471 764 1124498 SGTC_1170 0310-0127 64.8 µM -0.429268760015966 0.40866578141667 no 1993 0.333863824317092 762 774975 SGTC_2052 5265182 7.135 µM -0.429323471390708 0.408653545488468 no 1994 0.333843919027107 744 1239884 SGTC_2388 9080168 200 µM -0.430017863818278 0.408498255798822 no 1995 0.33359132330675 735 15943073 SGTC_27 0485-0001 32.618 µM -0.430403593073257 0.408411999864745 no 1996 0.333451041046481 728 2054479 SGTC_1427 4048-4900 550 nM -0.432133386349244 0.408025241890054 no 1997 0.332822235352175 743 24132586 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.43335906562183 0.407751251081899 no 1998 0.332376966952627 756 5357218 A potent inhibitor of glutathione S-transferases. SGTC_988 1497-1057 103 µM -0.433834174221293 0.407645056476016 no 1999 0.332204431652647 766 3533044 SGTC_2865 9030313 51.95 µM -0.435795817671844 0.407206668751562 no 2000 0.33149243928448 735 42562754 SGTC_2110 5483698 200 µM -0.436786869017333 0.406985232928221 no 2001 0.331132961381136 720 2848765 YHR062C RPP1 SGTC_1491 4138-0063 26.5 µM -0.437700564686422 0.406781107428798 no 2002 0.330801680050884 742 23883227 SGTC_2831 7999036 19.48 µM -0.438538443074359 0.406593942255314 no 2003 0.330498004440227 770 2988270 SGTC_507 nimesulide 162 µM -0.438607379034325 0.406578544298219 no 2004 0.330473024669543 738 4495 A COX2 inhibitor. SGTC_940 3232-1287 54.8 µM -0.44245977224371 0.405718280473766 no 2005 0.329078267091761 763 1585493 YIL048W NEO1 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.443026614774975 0.405591739255638 no 2006 0.328873242028628 757 61125 An anti-inflammatory. SGTC_1214 0358-0031 63.7 µM -0.444728557854073 0.405211858941608 no 2007 0.32825796440954 767 4301366 SGTC_2947 9072639 7.68 µM -0.445296190071335 0.405085181060842 no 2008 0.328052860412381 740 16488146 SGTC_182 3448-4371 550.524 µM -0.445325608184279 0.405078616122662 no 2009 0.328042232102978 695 3491403 SGTC_3040 9091894 49.47 µM -0.445445712028136 0.405051814058295 no 2010 0.327998841885705 716 25236966 SGTC_2167 5876490 200 µM -0.445633993942414 0.405009798447736 no 2011 0.327930825477787 769 686534 SGTC_3313 9133968 57.047 µM -0.446378418017669 0.404843688960129 no 2012 0.327661959899299 740 1494643 SGTC_1018 4259-0013 28.1 µM -0.449663560823383 0.404110853100397 no 2013 0.326476524862411 743 6801262 SGTC_600 1495-0418 41.6 µM -0.450419945435058 0.40394216954637 no 2014 0.326203832944965 739 5377768 SGTC_3189 9110682 49.47 µM -0.451621693639687 0.403674200894228 no 2015 0.325770769543131 751 17122418 SGTC_1059 3448-6867 171 µM -0.453486610249167 0.403258446942044 no 2016 0.325099191427666 736 3934407 SGTC_168 3970-0862 530.542 µM -0.453915210389096 0.403162912685936 no 2017 0.324944927706605 750 3135186 SGTC_1347 1493-0251 600 nM -0.45393580542191 0.403158322232972 no 2018 0.32493751580373 737 3986378 SGTC_1953 st076800 12.1 µM -0.454778887247247 0.402970418118696 no 2019 0.324634160371421 750 297591 SGTC_2827 7993847 71.43 µM -0.456853711855807 0.402508081548086 no 2020 0.323888098168752 743 2985692 SGTC_2077 5212015 200 µM -0.457348751832105 0.402397791097826 no 2021 0.323710196813954 745 780900 SGTC_1484 3473-2379 286 µM -0.457750516203681 0.402308287323195 no 2022 0.323565845298561 744 671917 SGTC_638 3970-0837 4.09 µM -0.458385388292117 0.40216686300368 no 2023 0.323337793709276 725 4118451 YLR208W SEC13 SGTC_3206 9114350 49.47 µM -0.460382729131119 0.40172201829206 no 2024 0.322620764575025 748 17087243 SGTC_264 promethazine 12.5 mM -0.462847302238584 0.401173287838522 no 2025 0.321736911409753 771 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3015 9080845 49.47 µM -0.462904145451885 0.401160634147815 no 2026 0.321716537985215 755 5296973 SGTC_2641 levomentholum 100 µM -0.46316777084188 0.401101950676217 no 2027 0.321622057866027 749 16666 SGTC_2520 obtusaquinone 4.71 µM -0.465231089545632 0.400642729502597 no 2028 0.32088298851656 749 5967872 SGTC_236 1509-0011 5.31 µM -0.465474826151078 0.400588491479441 no 2029 0.320795730194918 782 3107280 SGTC_41 0478-0632 82.643 µM -0.466508338974955 0.400358528076272 no 2030 0.320425840018276 777 3750424 SGTC_1431 4049-0260 9.09 µM -0.467053650855569 0.400237206509491 no 2031 0.320230746875948 760 3854841 SGTC_223 busulfan 5 mM -0.473496423011298 0.398804543509145 no 2032 0.317929526176518 745 2478 A DNA alkylator. SGTC_1713 st033146 12.748 µM -0.474301913140767 0.398625524119911 no 2033 0.317642313727125 778 674619 SGTC_1995 st072814 61.1 µM -0.474888047210438 0.398495269803668 no 2034 0.317433385703236 727 5769371 SGTC_1904 st060225 78 µM -0.476813456172487 0.398067473239413 no 2035 0.316747481446642 717 66595 SGTC_417 st075190 100 µM -0.477698254540908 0.397870925562187 no 2036 0.316432493412067 759 222757 SGTC_2119 5528445 120.635 µM -0.479218597400877 0.397533259614298 no 2037 0.315891562636612 751 791935 SGTC_1429 4049-0205 9.46 µM -0.484055999152292 0.396459391539079 no 2038 0.314173063658316 740 22774478 SGTC_1746 st038117 42 µM -0.486161598758925 0.395992208428939 no 2039 0.313426297864879 745 2898218 SGTC_1924 st058459 75.1 µM -0.486474998320029 0.395922685178685 no 2040 0.31331521375629 753 688683 SGTC_2980 9014342 25.29 µM -0.488209839947407 0.39553789509923 no 2041 0.312700607725867 769 2996599 SGTC_487 nimodipine 119 µM -0.4884192054847 0.395491464434078 no 2042 0.312626470510685 744 4497 L-type voltage-gated calcium channels inhibitor SGTC_1861 st057647 17.4 µM -0.490942765228364 0.394931935442059 no 2043 0.311733464499963 767 688668 SGTC_3133 9127736 49.47 µM -0.491099038457989 0.394897293322475 no 2044 0.311678200779145 745 27243420 SGTC_2923 7992654 58.14 µM -0.491193375907112 0.394876381318843 no 2045 0.311644841785637 725 2985126 SGTC_3299 9121982 43.1275 µM -0.491587230112194 0.394789078005542 no 2046 0.311505586330956 765 17594604 YPL160W CDC60 SGTC_106 0092-0003 11.579 µM -0.492474360550592 0.394592452447978 no 2047 0.311192021443134 757 1072148 SGTC_2531 methyl deoxycholate 70.07 µM -0.493060498137082 0.394462554341235 no 2048 0.310984920538293 778 16667744 Haematoxylin. SGTC_1356 1502-0781 85.8 µM -0.493254692272246 0.394419520189267 no 2049 0.310916318817821 749 567702 SGTC_2580 diallyl disulphide 81.36 µM -0.493276573631235 0.394414671278448 no 2050 0.310908589341909 736 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2769 toremifene 3.73 µM -0.494655875380591 0.394109050956497 no 2051 0.310421526690354 738 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_378 3970-0959 8.33 µM -0.49519927090123 0.393988665378765 no 2052 0.310229732617367 781 6615653 SGTC_3251 9135047 49.47 µM -0.496642102823067 0.393669064971885 no 2053 0.309720728649841 741 17682963 SGTC_1138 3761-0006 1.03 µM -0.498956680118915 0.393156514703229 no 2054 0.308904951238056 768 12061087 SGTC_2782 7736369 71.43 µM -0.499170416030395 0.393109193399085 no 2055 0.308829667025871 753 2950836 YOL077C BRX1 SGTC_790 1575-0012 79.1 µM -0.500920482421449 0.392721786750522 no 2056 0.308213543390979 767 378741 YLR208W SEC13 SGTC_334 1502-1024 68.5 µM -0.502042902791805 0.392473376014488 no 2057 0.307818671193822 768 3296216 SGTC_1983 st071813 46.9 µM -0.503894107079196 0.392063768731774 no 2058 0.307167895924567 754 11838595 SGTC_2571 chrysanthemic acid 100 µM -0.50398084410722 0.39204457976606 no 2059 0.307137419121115 803 2743 An insecticide. SGTC_1502 4534-4282 27.7 µM -0.50610487720646 0.391574758714623 no 2060 0.306391513449316 781 3278949 SGTC_279 1273-0055 2.93 µM -0.506387227990781 0.391512316615393 no 2061 0.306292419424465 783 2847562 SGTC_2264 7948757 110.76 µM -0.50639935045233 0.391509635786007 no 2062 0.306288165234194 768 2971411 SGTC_2643 anethole 100 µM -0.507905274054818 0.391176647480804 no 2063 0.305759887931145 787 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1630 st005209 31.3 µM -0.508049559710652 0.391144747365222 no 2064 0.305709293779281 766 3367314 SGTC_3069 9117009 49.47 µM -0.508597320657418 0.391023649566546 no 2065 0.305517253706847 749 41904981 SGTC_1695 st026914 34.495 µM -0.509584587010328 0.390805413558039 no 2066 0.305171262105499 764 3289191 SGTC_1902 st060212 70.5 µM -0.510123978732213 0.390686195112584 no 2067 0.304982303527571 741 688944 SGTC_2929 9013348 24.6 µM -0.512086680471649 0.390252477973841 no 2068 0.304295173006774 752 2995952 SGTC_713 1488-1073 324 µM -0.515848314548228 0.389421615489146 no 2069 0.302980177568619 774 3312542 SGTC_2253 7938677 135.83 µM -0.517818997547637 0.388986536255509 no 2070 0.302292281133643 754 2301972 SGTC_353 1988-1175 58.3 µM -0.518832459550294 0.388762842466216 no 2071 0.301938790096981 780 2788357 SGTC_1710 st031758 61.5 µM -0.520811229553585 0.388326189910309 no 2072 0.301249139772588 774 5394341 SGTC_2034 5197015 53.07 µM -0.521004499531915 0.388283548835624 no 2073 0.30118181844923 792 780676 SGTC_2803 7707263 71.43 µM -0.522320188294614 0.387993304782613 no 2074 0.300723707594751 754 2199229 SGTC_224 benfluorex 43.875 µM -0.52285364253738 0.387875641330043 no 2075 0.300538053318342 778 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_880 0833-0487 87.2 µM -0.524258275275013 0.387565872199055 no 2076 0.300049456749211 761 76075 SGTC_1119 parthenolide 318.541 nM -0.524504651764963 0.387511545202783 no 2077 0.299963792607786 801 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1817 st052116 64.4 µM -0.524571482968857 0.387496809036142 no 2078 0.299940557568108 761 4361398 SGTC_2821 7996764 71.43 µM -0.526812126149873 0.387002844967685 no 2079 0.299162030611713 719 2987135 SGTC_1966 st070145 16.1 µM -0.527241981221215 0.386908101569456 no 2080 0.299012779408785 762 3748532 SGTC_747 3448-8087 38.7 µM -0.527400664608912 0.386873128220263 no 2081 0.29895769104436 793 5168703 SGTC_3135 9127742 49.47 µM -0.527912970264 0.386760223840689 no 2082 0.298779871003954 759 3643468 SGTC_2420 aureobasidin a 50 nM -0.528137153665032 0.38671082024037 no 2083 0.298702072616535 760 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_741 4582-0002 126 µM -0.528409663759792 0.386650769293162 no 2084 0.298607515815243 752 2912688 SGTC_2342 7990637 118.86 µM -0.528434562213665 0.386645282748262 no 2085 0.298598877114366 801 2033102 YER133W GLC7 SGTC_2236 dapsone 200 µM -0.52921483498076 0.386473355784121 no 2086 0.298328213377362 762 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2011 4012611 177 µM -0.529840811267479 0.386335442942979 no 2087 0.298111153317879 765 2049887 SGTC_927 2425-1185 123 µM -0.530453806350038 0.386200403988466 no 2088 0.297898664304561 771 730375 SGTC_3263 9137018 49.47 µM -0.530975564104959 0.386085474901248 no 2089 0.29771785628025 776 43844957 SGTC_2655 perillic acid 100 µM -0.53129557719772 0.386014989638212 no 2090 0.297606984890754 778 5702197 An apoptosis inducer. SGTC_3056 9094900 49.47 µM -0.532400431403257 0.385771666217446 no 2091 0.297224343227925 772 25236784 SGTC_2876 9059903 25.97 µM -0.532563740360677 0.385735704291816 no 2092 0.297167803884981 775 6916095 SGTC_1094 duloxetine 25.4 µM -0.53269879434589 0.385705965076719 no 2093 0.297121050436293 755 60834 A selective serotonin reuptake inhibitor. SGTC_2885 9057732 51.95 µM -0.533037471955137 0.385631390400932 no 2094 0.297003820662272 783 6471414 SGTC_2505 galangin 7.89 µM -0.535427726614647 0.385105191736268 no 2095 0.296177060822982 774 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_515 4092-1064 102 µM -0.53736417038961 0.384679051543106 no 2096 0.295508043794863 811 717353 SGTC_2661 dactinomycin 12.96 µM -0.54014319915165 0.384067732826783 no 2097 0.294549140479664 770 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1610 st001799 48.1 µM -0.540678152175699 0.383950089221994 no 2098 0.294364719966684 772 621897 SGTC_878 0828-0289 13.7 µM -0.540869360694034 0.383908042404929 no 2099 0.294298815389904 777 745350 YLR208W SEC13 SGTC_1349 flufenamic acid 69 µM -0.542423700868356 0.383566293229215 no 2100 0.293763328009889 776 3371 A non-steroidal anti-inflammatory. SGTC_1128 3448-9350 235 µM -0.542673500990076 0.383511378694255 no 2101 0.293677311172754 732 619386 SGTC_3320 9137005 35.139 µM -0.542842387450602 0.383474253050689 no 2102 0.293619162966542 776 4908713 SGTC_3046 9092212 49.47 µM -0.543773292839002 0.383269635005746 no 2103 0.293298744648733 775 25236637 SGTC_796 1234-0020 70.7 µM -0.546875995227283 0.382587879625696 no 2104 0.292231964215964 750 46495034 SGTC_1654 st012436 41.8 µM -0.546900343339626 0.382582531061629 no 2105 0.292223599917573 782 4323132 SGTC_1392 3455-1037 33.9 µM -0.54765616078006 0.382416511345966 no 2106 0.291964009629334 772 981132 SGTC_1423 4048-0112 5.59 µM -0.549745759474685 0.381957631336051 no 2107 0.291246883109549 768 X1423 SGTC_897 1000-0139 31.4 µM -0.550783352263273 0.381729835465481 no 2108 0.290891098834688 776 6151020 SGTC_3038 9091290 49.47 µM -0.551011509748269 0.381679750656237 no 2109 0.290812892270135 796 25236843 SGTC_1676 st018489 23.4 µM -0.552097943678938 0.381441285398656 no 2110 0.290440625354244 779 3696235 SGTC_1068 loratadine 26.9 µM -0.552390555852741 0.381377066597497 no 2111 0.290340399848765 790 3957 A H1 histamine antagonist. SGTC_3088 9117578 49.47 µM -0.552490582429006 0.381355114784681 no 2112 0.290306142466276 803 678341 SGTC_640 3381-0960 37.1 µM -0.557201315319034 0.380321731690171 no 2113 0.2886949455771 786 1745025 SGTC_2691 st077356 60.2 µM -0.55722189967024 0.380317218014216 no 2114 0.288687914427529 782 2839272 SGTC_1049 3226-0134 66 µM -0.557687926075574 0.380215033477665 no 2115 0.288528751915745 775 5702385 SGTC_2639 lactacystin 53 µM -0.558764546224029 0.379978997433314 no 2116 0.288161210837835 765 3870 A proteasome inhibitor. SGTC_2274 7947094 46.08 µM -0.559290589740111 0.379863684957419 no 2117 0.287981708274634 754 2971028 SGTC_528 3492-0019 172 µM -0.55980244597211 0.379751492687559 no 2118 0.28780709754482 776 2869262 SGTC_2340 7987427 183.45 µM -0.560119858835665 0.379681924974458 no 2119 0.287698842869824 776 2239331 SGTC_2989 9073649 71.4286 µM -0.564939239824075 0.378626135809962 no 2120 0.286057546248024 814 21367202 SGTC_3017 9080681 49.47 µM -0.566116280253828 0.378368417004411 no 2121 0.285657368403204 798 16451914 SGTC_752 1896-0090 130 µM -0.566970672621236 0.3781813774622 no 2122 0.285367053494565 785 772567 SGTC_1298 1079-1278 263 µM -0.569180016612309 0.377697850749209 no 2123 0.284616990313582 800 2840950 SGTC_2814 7977482 42.97 µM -0.569444069542701 0.377640074159933 no 2124 0.28452740844494 790 6456762 SGTC_2349 9023730 187.07 µM -0.569938294771497 0.377531941654018 no 2125 0.284359775157552 797 4126287 SGTC_2957 9076800 11.52 µM -0.571039484558964 0.377291044714586 no 2126 0.283986439035521 795 16459615 SGTC_2309 7664088 163.95 µM -0.571419223477024 0.377207983866249 no 2127 0.283857750641222 785 704922 SGTC_2472 5377652 49.4 µM -0.572121684403453 0.377054348537903 no 2128 0.283619769720392 812 1610903 SGTC_2112 5488546 200 µM -0.574523273092659 0.376529243880017 no 2129 0.282806878155344 810 600757 SGTC_1881 5652484 16 µM -0.575274632009086 0.376365006960226 no 2130 0.282552787655074 799 2255129 SGTC_913 3487-1245 167 µM -0.575532198810082 0.376308711483209 no 2131 0.282465710372698 762 4016153 SGTC_3077 9117319 49.47 µM -0.577716164030378 0.375831475681762 no 2132 0.281727882160427 815 17154678 SGTC_2068 5226020 147 µM -0.579529268110292 0.375435423936641 no 2133 0.281116051914209 804 1810509 SGTC_1588 farnesol 29.9 µM -0.580573044584005 0.375207482463315 no 2134 0.28076412187466 778 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1490 4089-0339 670 nM -0.581841389576902 0.37493055802506 no 2135 0.280336761048631 787 742542 SGTC_653 0203-0016 55.2 µM -0.582651804187536 0.37475364968425 no 2136 0.280063862016635 790 295302 SGTC_1730 st033808 45.1 µM -0.582995707930566 0.37467858565305 no 2137 0.279948094790977 801 1045166 SGTC_132 0417-1715 25.805 µM -0.583366259350318 0.374597710535555 no 2138 0.279823383218236 816 6769098 SGTC_1564 D-Arginine 115 µM -0.589554395487974 0.373247929691452 no 2139 0.277744716899938 824 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1006 4099-6547 255 µM -0.590289856457314 0.373087611024365 no 2140 0.277498169352144 805 3146833 SGTC_1862 st057513 3.81 µM -0.592200709504912 0.372671178551005 no 2141 0.27685809719302 805 5393163 SGTC_1296 1068-0102 11.9 µM -0.592578245161979 0.372588919738683 no 2142 0.276731720909144 791 767053 SGTC_316 k060-0003 58.6 µM -0.596795879338262 0.371670362468161 no 2143 0.275321834717713 797 6152314 SGTC_1187 1391-0724 117 µM -0.597498271768337 0.371517459418229 no 2144 0.275087380249487 795 6997986 SGTC_693 4161-2696 114 µM -0.597581362744532 0.371499372773672 no 2145 0.27505965147522 814 805759 SGTC_559 1550-0661 158 µM -0.598728628885506 0.37124967317045 no 2146 0.274676931397454 789 5830875 SGTC_1753 st043925 64 µM -0.599929590468659 0.370988344936933 no 2147 0.274276580433771 800 670181 SGTC_2047 4141938 200 µM -0.601830440486873 0.370574843197479 no 2148 0.273643505105406 798 3807862 SGTC_1234 0326-0494 15.5 µM -0.602949420096876 0.370331495634398 no 2149 0.27327116894396 820 1547813 SGTC_1066 ketoconazole 628 nM -0.603645835139574 0.370180070534223 no 2150 0.273039566279893 812 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.604333800197809 0.370030502511264 no 2151 0.272810869355313 806 4620898 SGTC_469 w7 172 µM -0.6052223570456 0.369837353633135 no 2152 0.27251563135522 792 45115570 A P450 inhibitor. SGTC_2355 9061122 103.12 µM -0.60542155323172 0.369794058127143 no 2153 0.272449466837705 810 5302957 SGTC_2601 securinine 100 µM -0.607353250883158 0.369374287243477 no 2154 0.271808252978353 822 442872 A GABA receptor antagonist. SGTC_231 b-estradiol 524 µM -0.607452810771708 0.369352656425045 no 2155 0.271775225113202 788 450 A steroid. SGTC_555 4296-0685 37 µM -0.607699394017934 0.369299084447372 no 2156 0.27169343251488 818 2908540 YHR072W ERG7 SGTC_1208 2323-2347 50.3 µM -0.608475172915472 0.369130557479025 no 2157 0.27143618365762 800 5412760 SGTC_2871 9038510 12.99 µM -0.609080444632864 0.368999088243881 no 2158 0.271235559413987 830 4945164 SGTC_3009 9080819 71.4286 µM -0.612627410545326 0.36822897102303 no 2159 0.2700613648404 805 17027216 SGTC_1778 st046819 58.9 µM -0.612686832685327 0.368216073786684 no 2160 0.270041715299453 813 671715 SGTC_2772 vinpocetine 57.06 µM -0.613280930649905 0.368087136381452 no 2161 0.269845300044197 825 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1019 4262-0212 3.4 µM -0.614010772242286 0.367928758803077 no 2162 0.269604104413143 812 4677213 SGTC_2117 5521686 200 µM -0.615418713299896 0.367623295273162 no 2163 0.269139118095249 791 803312 SGTC_1072 oxiconazole 14.9 nM -0.615487277903278 0.367608421796918 no 2164 0.269116484242662 785 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2607 solasodine 47.35 µM -0.616411128956656 0.367408033435909 no 2165 0.26881160505408 803 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_392 N-ethylmaleimide 8.33 µM -0.618529380758929 0.366948709364179 no 2166 0.268113218327265 789 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2856 9022925 19.48 µM -0.618665108223657 0.366919284554263 no 2167 0.268068500191989 791 4944862 SGTC_2986 9022445 71.43 µM -0.61976080207367 0.366681774074561 no 2168 0.267707639428005 822 6459286 SGTC_1382 3002-2117 298 µM -0.620162632798669 0.366594683142427 no 2169 0.267575360059397 835 1497314 SGTC_621 3584-0052 32.1 µM -0.620462829287808 0.366529624426262 no 2170 0.2674765593538 822 2273927 SGTC_3178 9107506 49.47 µM -0.62096098335463 0.366421672719094 no 2171 0.267312647431334 798 8897194 SGTC_942 3253-1115 227 µM -0.622895816168676 0.366002488072863 no 2172 0.266676493792505 838 46497897 SGTC_1603 st002045 67.8 µM -0.623381754605511 0.365897233830221 no 2173 0.266516842433656 806 5887985 SGTC_1297 1068-0111 14.1 µM -0.623700354291241 0.365828230630487 no 2174 0.266412195185591 811 767057 SGTC_2406 ethylparaben 405.7 µM -0.624352001739862 0.365687108546643 no 2175 0.266198219837345 800 8434 A possible steroid mimic. SGTC_844 0330-0132 15.3 µM -0.62498592085153 0.365549843187542 no 2176 0.265990149296027 802 2828079 SGTC_1945 st075991 56.6 µM -0.628080006055259 0.364880114373776 no 2177 0.264975765087287 793 1084980 SGTC_7 0192-1582 4.227 µM -0.628466296008682 0.364796529048787 no 2178 0.264849259541297 836 252616 SGTC_2260 7964312 200 µM -0.630285538211947 0.364402968320173 no 2179 0.264253891552743 810 231951 SGTC_2910 7948405 25.97 µM -0.633159750347447 0.363781474966522 no 2180 0.263314663435419 804 2971328 SGTC_1645 Cervolide 78 µM -0.635901075411913 0.363189049602497 no 2181 0.262420450848421 809 23173 A fragrance. SGTC_1183 1254-0324 198 µM -0.636425219853669 0.363075814418253 no 2182 0.262249653632103 805 5799357 SGTC_99 0109-0120 622.8 µM -0.639102661250768 0.362497571896408 no 2183 0.261378074393805 819 759414 SGTC_375 3970-0961 9.27 µM -0.639140542383482 0.362489393018049 no 2184 0.261365753747379 797 2898222 SGTC_1606 st000094 49.2 µM -0.640150545221334 0.362271347445858 no 2185 0.26103736547997 794 1242210 SGTC_3246 9135460 32.98 µM -0.641948818094144 0.361883235961295 no 2186 0.260453207763745 820 41446951 SGTC_879 0831-1030 162 µM -0.647276855420905 0.360734149556974 no 2187 0.258726388984534 817 1549252 SGTC_2457 5731572 11.68 µM -0.648539032465971 0.360462122189042 no 2188 0.258318186882899 818 2865357 SGTC_154 3389-1638 511.116 µM -0.650474592866328 0.360045102859845 no 2189 0.257692854073644 850 5238686 SGTC_477 mead ethanolamide 10 µM -0.651057093409946 0.359919634835162 no 2190 0.257504816183463 779 16061185 SGTC_1508 1080-0625 72.9 µM -0.651626314153344 0.359797041799799 no 2191 0.257321134044134 815 767111 SGTC_519 k048-0011 62.8 µM -0.65508897142245 0.359051600668583 no 2192 0.256205236150136 809 6836379 SGTC_121 0557-0495 61.343 µM -0.655250676803232 0.359016801808612 no 2193 0.256153185683545 841 3104427 SGTC_2302 7771753 200 µM -0.65586203193964 0.35888524927914 no 2194 0.255956449744363 811 2203047 SGTC_284 0988-0104 32.6 µM -0.658513559175903 0.358314882619187 no 2195 0.255104093582697 830 4666532 SGTC_1339 1486-1321 22.7 µM -0.658820402017481 0.358248898420439 no 2196 0.255005552251252 815 3469382 SGTC_176 1486-1328 72.834 µM -0.659152945850588 0.35817739220048 no 2197 0.254898779641966 816 22310231 SGTC_2358 9037157 4 µM -0.659450021159248 0.358113516911345 no 2198 0.254803414996915 819 2388925 SGTC_2098 5376439 882.5 nM -0.660649485518312 0.357855655933143 no 2199 0.254418562951347 808 2844116 SGTC_2618 avocadyne 43.43 µM -0.661878310804095 0.35759155018808 no 2200 0.254024606489727 822 3015189 SGTC_407 eburnamonine 100 µM -0.664822029384606 0.356959147838306 no 2201 0.253082165388831 813 3195 SGTC_48 0382-0018 55 µM -0.665506751184415 0.356812104542813 no 2202 0.252863213450303 803 762596 SGTC_2711 st079103 59.1 µM -0.669038330310481 0.356054039830868 no 2203 0.251735513662482 819 54693780 SGTC_1398 3558-0053 112 µM -0.67126328184673 0.355576738680009 no 2204 0.251026410716654 806 4532369 SGTC_3264 9137442 49.47 µM -0.673510340241303 0.355094924872285 no 2205 0.250311336312285 820 17015726 SGTC_1272 0839-0021 27 µM -0.673812203560071 0.355030217029615 no 2206 0.250215357636634 834 5027250 SGTC_3228 9131799 49.47 µM -0.675395310068747 0.354690928605451 no 2207 0.249712322191059 831 17015818 SGTC_3332 9141069 11.198 µM -0.679186817311465 0.353878808810245 no 2208 0.248509749489902 827 17332883 SGTC_926 2268-1401 59.4 µM -0.679376371443776 0.353838224776218 no 2209 0.248449708687801 835 2931578 SGTC_2310 7668677 200 µM -0.683367395682087 0.352984122331721 no 2210 0.24718735852944 841 2197143 SGTC_2391 6285546 200 µM -0.683618888738112 0.35293032610034 no 2211 0.247107926998337 829 846083 SGTC_761 k216-0224 480 µM -0.685718868805354 0.352481239632235 no 2212 0.246445202898689 867 1340404 SGTC_2916 7875993 68.79 µM -0.690378800393568 0.351485435463735 no 2213 0.244978002405981 855 1299250 SGTC_1035 k081-0041 55.2 µM -0.691675786605945 0.351208456849647 no 2214 0.244570478081101 829 731709 SGTC_1164 k060-0068 93.7 µM -0.692725100159875 0.350984427921743 no 2215 0.244241042052836 836 5963676 SGTC_2464 5717415 7.67 µM -0.693306832071459 0.350860250198911 no 2216 0.244058508208652 823 5285744 SGTC_193 1273-0060 1.558 µM -0.693547816304071 0.350808813860723 no 2217 0.243982914561666 835 2847393 YHR072W ERG7 SGTC_1122 capsaicin 818.572 nM -0.695033023879806 0.350491867452257 no 2218 0.243517303036915 831 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1529 apigenin 74 µM -0.696037057443077 0.350277663522458 no 2219 0.243202811339033 841 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1020 4335-0961 93.3 µM -0.696110575446352 0.350261980812129 no 2220 0.243179792052569 860 669075 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.698554515689635 0.349740789930331 no 2221 0.242415238655242 835 756377 SGTC_3025 9087895 49.47 µM -0.699645863408616 0.349508142176535 no 2222 0.242074246471718 840 17173641 SGTC_1790 st045711 43.5 µM -0.701223699243412 0.349171887389636 no 2223 0.241581711023162 794 585119 SGTC_1876 myriocin 605 nM -0.703189183955778 0.34875318579752 no 2224 0.240968929412825 854 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_343 4130-2827 29.8 µM -0.706666465780291 0.348012881703496 no 2225 0.239886886870509 824 1118244 SGTC_2439 5492030 7.2 µM -0.708349629060573 0.347654748441417 no 2226 0.239364082262325 839 5722370 SGTC_1633 st005664 67.9 µM -0.709470702518186 0.347416288625961 no 2227 0.239016213051302 843 2063822 SGTC_2954 9074818 52.69 µM -0.712751905840058 0.34671870201427 no 2228 0.237999645483282 848 16648742 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.713887751753179 0.346477341098264 no 2229 0.23764829586137 874 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_3250 9135583 49.47 µM -0.714475664827301 0.346352437321071 no 2230 0.237466549370758 831 7699353 SGTC_171 k064-0041 9.68 µM -0.716110709037389 0.346005155484602 no 2231 0.236961495871122 833 53325 SGTC_2649 anisomycin 9.56 µM -0.716601823261192 0.345900868565011 no 2232 0.236809909579017 837 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_661 1304-0007 33.6 µM -0.71780579317895 0.34564525792618 no 2233 0.236438520432061 845 3117130 SGTC_1596 piperlongumine 63 µM -0.718944435462508 0.345403581496385 no 2234 0.236087578108197 822 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3286 9117135 37.221 µM -0.719595781176136 0.345265361921062 no 2235 0.235886955160302 839 3438150 SGTC_2304 7443016 91.4 µM -0.719845658691727 0.345212341847847 no 2236 0.235810014585478 854 939854 SGTC_2988 9073640 71.4286 µM -0.720006592682883 0.345178195797953 no 2237 0.235760468218332 841 9102229 SGTC_205 1486-1330 71.903 µM -0.721636549173107 0.344832432061099 no 2238 0.235258980987371 838 4118834 SGTC_996 3970-0799 1.8 µM -0.723143420423956 0.344512893711292 no 2239 0.234795887691203 845 6615648 YGL040C HEM2 SGTC_2294 7971431 200 µM -0.726657853007163 0.343768074958716 no 2240 0.233717789191429 875 5741572 SGTC_2007 4011539 71.82 µM -0.728942605905663 0.343284188823497 no 2241 0.233018385617728 845 45595301 SGTC_2899 9053889 58.44 µM -0.72975574124482 0.343112037408158 no 2242 0.232769751126846 830 6470052 SGTC_2182 6325192 200 µM -0.730369342787753 0.342982151465594 no 2243 0.23258222624 822 736248 SGTC_2070 5230947 200 µM -0.730527631112347 0.342948648320551 no 2244 0.232533864830104 870 2835538 SGTC_337 1315-0038 354 µM -0.731645067660987 0.342712167984112 no 2245 0.232192616530862 844 1626437 SGTC_3258 9138477 49.47 µM -0.731687196490048 0.342703253568966 no 2246 0.232179756474719 857 4970355 SGTC_249 wiskostatin 11.211 µM -0.732796648851864 0.342468526176525 no 2247 0.231841232765747 829 2775510 A n-wasp and actin depolymerizer. SGTC_1553 gossypol 38.6 µM -0.732906290374096 0.342445332566018 no 2248 0.231807793127053 833 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2136 5328288 199.296 µM -0.737550701299136 0.341463398669046 no 2249 0.230393761225558 848 262395 SGTC_2511 berberine 10.47 µM -0.738251596845447 0.341315306387886 no 2250 0.230180786973975 855 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1102 cgs 12066b 26.1 µM -0.738443262667153 0.341274813553097 no 2251 0.230122566542686 838 6438352 A 5-HT1B full agonist. SGTC_704 1310-0270 142 µM -0.738831212761598 0.341192857746642 no 2252 0.230004747997498 856 5718033 SGTC_473 2-arachidonoylglycerol 10 µM -0.741091952583577 0.340715417717726 no 2253 0.229318844329586 837 5282280 An endocannabinoid. SGTC_516 3992-2719 87.3 µM -0.744372070382118 0.340023151436079 no 2254 0.228325705502218 856 5350887 YDR037W KRS1 SGTC_1163 k060-0048 49.9 µM -0.745690026948908 0.339745149404725 no 2255 0.227927342536642 842 6809982 SGTC_94 0334-0113 514.748 µM -0.747817213323087 0.339296637068535 no 2256 0.227285208967811 856 6795178 SGTC_1688 st021091 57.6 µM -0.747826360498905 0.339294708898618 no 2257 0.227282449913632 869 3656366 SGTC_2353 9059630 146.67 µM -0.748435813466151 0.339166249343137 no 2258 0.227098663703955 851 4779114 SGTC_2560 caryophyllene 100 µM -0.748716698071703 0.339107051211868 no 2259 0.227013988552397 857 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1578 josamycin 24.2 µM -0.750208591168146 0.338792692314354 no 2260 0.226564542681786 847 5282165 A P450 substrate. SGTC_2280 7785178 200 µM -0.750609922258025 0.338708146425281 no 2261 0.226443723968506 848 2954328 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.751612100961438 0.33849705925074 no 2262 0.226142182006141 874 6708760 SGTC_3105 9121040 49.47 µM -0.752998347135454 0.338205160238156 no 2263 0.225725453629048 809 41448907 SGTC_3200 9114385 49.47 µM -0.757571348192754 0.337242922965872 no 2264 0.224353819028313 832 17018030 YLR208W SEC13 SGTC_355 1311-2252 105 µM -0.760058295299739 0.336720073047039 no 2265 0.22360986996708 871 5338538 SGTC_2151 5563267 85.4165 µM -0.763474332443716 0.336002407769148 no 2266 0.222590282140904 862 5310824 SGTC_967 1306-0166 352 µM -0.764524012097461 0.335782003510734 no 2267 0.22227751642931 858 4437607 SGTC_3230 9131665 49.47 µM -0.76577563553161 0.335519270353376 no 2268 0.221904906894317 845 15943720 SGTC_3146 9095609 49.47 µM -0.765918634289691 0.335489258041866 no 2269 0.22186235873925 867 17173999 SGTC_1032 k061-1018 98.7 µM -0.766045960407633 0.335462535958112 no 2270 0.22182447777666 869 4005393 SGTC_2529 gangaleoidin 93.61 µM -0.767348078498169 0.335189306685814 no 2271 0.221437295029735 870 4565183 SGTC_2496 diffractaic acid 79.83 µM -0.772103224487793 0.334192254473918 no 2272 0.220026646298811 866 94870 An apoptosis inducer which activates caspases. SGTC_1485 3909-9022 254 µM -0.772770324624234 0.334052471205325 no 2273 0.219829159381988 876 714516 SGTC_2886 9058944 51.95 µM -0.775037327423877 0.333577618592155 no 2274 0.219158801514474 818 4949929 SGTC_2334 9017922 200 µM -0.775196519435077 0.333544283802919 no 2275 0.219111772279215 861 3163164 SGTC_98 0074-0023 107.663 µM -0.775553650722475 0.333469505333097 no 2276 0.219006288027452 847 3563821 SGTC_910 3454-3003 490 µM -0.775569153691112 0.333466259370607 no 2277 0.219001709647318 874 820824 SGTC_3215 9129942 49.47 µM -0.777222033824423 0.333120256136648 no 2278 0.218513892350914 876 17682944 SGTC_527 4476-4215 268 µM -0.779809769408561 0.332578841572739 no 2279 0.217751427559065 843 4418754 SGTC_1546 5-methoxyflavanone 78.7 µM -0.780617539586629 0.332409908664873 no 2280 0.217513736355362 849 147795 SGTC_325 2810-4341 181 µM -0.780896977678211 0.332351476339546 no 2281 0.217431544904864 844 774970 SGTC_3147 9097027 49.47 µM -0.781787324426096 0.332165326213692 no 2282 0.217169785791385 892 25236841 SGTC_1401 3807-4679 7.6 µM -0.783962030931375 0.331710821456215 no 2283 0.216531194907927 865 3291456 SGTC_328 k915-0120 63.5 µM -0.788237889774929 0.330817906989638 no 2284 0.215278785048068 855 6624543 SGTC_2268 7933382 153.85 µM -0.789431318447396 0.33056885839858 no 2285 0.214929978624269 872 935025 YOR257W CDC31 SGTC_3326 9140064 16.379 µM -0.791718383956051 0.330091795769294 no 2286 0.214262450231784 882 1868434 SGTC_2693 st077581 40.7 µM -0.791998003301499 0.330033488454563 no 2287 0.214180920238861 855 25238761 SGTC_721 1187-1332 279 µM -0.792565858763142 0.32991508972915 no 2288 0.214015403380958 886 25730 SGTC_1587 estradiol valerate 56.1 µM -0.793128954467704 0.329797700243468 no 2289 0.2138513474256 877 13791 A steroid. SGTC_2701 st077767 14.721 µM -0.795882253918891 0.329223956930575 no 2290 0.213050238403996 858 5721188 SGTC_2093 5331342 194.4 µM -0.797718899441925 0.328841452953432 no 2291 0.212516816893843 853 33839 SGTC_884 0851-0618 334 µM -0.798332518357498 0.328713699198333 no 2292 0.212338776043219 874 9642473 SGTC_1400 3771-8998 51.5 µM -0.79908776317956 0.328556486800153 no 2293 0.21211976230093 854 670767 SGTC_2820 7989630 71.43 µM -0.7994093627608 0.328489551570367 no 2294 0.212026541622587 817 2984098 SGTC_2281 7943571 200 µM -0.800181117278494 0.328328947055851 no 2295 0.211802934239016 865 1244024 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.800211118532669 0.328322704341929 no 2296 0.211794244492756 876 165506 SGTC_980 1473-0395 201 µM -0.802488184680315 0.327849028400086 no 2297 0.211135310166141 878 768876 SGTC_2752 diclazuril 33.15 µM -0.802918481694432 0.327759548969679 no 2298 0.211010926503274 868 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2247 cerulenin 830 nM -0.803368763928465 0.327665924239981 no 2299 0.210880811825637 849 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2113 5491891 107.031 µM -0.807056762147536 0.326899507079632 no 2300 0.209816890662441 862 789979 SGTC_25 0118-0223 35.662 µM -0.807403078316721 0.326827575204322 no 2301 0.209717146998479 861 5333628 SGTC_3260 9137109 49.47 µM -0.809476020527509 0.326397147713239 no 2302 0.209120695226148 844 17478346 SGTC_2625 euphol 100 µM -0.810847076466824 0.326112587403106 no 2303 0.208726747961955 858 6708538 A triterpene alcohol. SGTC_2873 9040596 71.43 µM -0.812187941744417 0.325834391009555 no 2304 0.208341898780322 888 6463863 SGTC_1795 st049545 62.3 µM -0.812729215396986 0.325722117566056 no 2305 0.208186663489695 834 5291882 SGTC_1848 st056003 16.4 µM -0.81428775144144 0.32539892723445 no 2306 0.207740062465435 858 146492 SGTC_616 4092-0450 108 µM -0.815791024912866 0.325087320932548 no 2307 0.20730983366697 898 787165 SGTC_2804 7954240 19.48 µM -0.82161506414202 0.323881240286279 no 2308 0.205648006483639 867 828705 SGTC_166 k072-0058 166.424 µM -0.825058414466765 0.32316903626919 no 2309 0.204669213833456 879 5846229 SGTC_1798 st045719 60.953 µM -0.826979731917299 0.322771922665708 no 2310 0.204124274722635 857 3980186 SGTC_812 4251-0442 148 µM -0.828195534913012 0.322520734893595 no 2311 0.203779886064008 905 5723007 SGTC_2697 mebhydrolin 72.4 µM -0.830015281988286 0.322144922199163 no 2312 0.203265071721704 897 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_780 0109-0199 192 µM -0.83156568115663 0.321824878395074 no 2313 0.202827070049426 870 610414 SGTC_1377 2944-0135 198 µM -0.83295900525367 0.321537371805626 no 2314 0.202433924952979 877 1894137 SGTC_1499 4480-0877 67.3 µM -0.836864797903581 0.32073199795302 no 2315 0.201334284705491 865 2861909 SGTC_815 1582-0027 36.9 µM -0.839441310245589 0.32020118271446 no 2316 0.200610855224936 900 3128206 SGTC_24 0417-1663 219 µM -0.840458316359522 0.31999175942628 no 2317 0.200325731839643 908 4329390 SGTC_409 arachidonic acid 100 µM -0.845312209275083 0.318993030143074 no 2318 0.198968273008488 885 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_554 4483-2211 187 µM -0.848362175057195 0.318366145060403 no 2319 0.198118150562938 895 747107 SGTC_153 4077-0274 519.67 µM -0.851107704384713 0.317802277771522 no 2320 0.197354763026114 882 3121976 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.859143133562171 0.316154419300362 no 2321 0.195130776286626 883 2333 A French combination drug. SGTC_2450 5739737 12.93 µM -0.86027204934137 0.315923199199146 no 2322 0.194819548260899 883 2262825 SGTC_1224 0823-0416 294 µM -0.867665835172047 0.31441061634137 no 2323 0.192788647097414 890 3598164 SGTC_2115 tiliquinol 12.7705 µM -0.868073082873568 0.314327393846693 no 2324 0.192677162730982 890 71208 A bioactive hydroxyquinoline. SGTC_1314 1222-0010 41.1 µM -0.869080690629943 0.314121526236317 no 2325 0.192401498713936 901 3526027 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.869651310125707 0.314004966755947 no 2326 0.192245494121189 867 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2608 thymoquinone 42.66 µM -0.870117273740603 0.31390979891608 no 2327 0.192118159341922 902 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1835 st008666 49.2 µM -0.871822356659118 0.313561660411347 no 2328 0.191652648098828 884 690455 SGTC_1527 coumarin 137 µM -0.872116607667851 0.313501597946181 no 2329 0.191572383452726 924 323 A hepatotoxic, DNA x-linker. SGTC_831 k061-1017 217 µM -0.874149543567481 0.313086770580374 no 2330 0.191018409856596 922 1240153 SGTC_2212 7123476 200 µM -0.874956549648611 0.312922163829107 no 2331 0.190798773962496 876 1085715 SGTC_508 roscovitine 141 µM -0.875860457513526 0.312737836087687 no 2332 0.190552949215705 915 160355 A CDKinase inhibitor. SGTC_2828 7998861 71.43 µM -0.880190887215149 0.311855411292749 no 2333 0.1893779546502 844 2988188 SGTC_1442 4112-3290 3 µM -0.881101716549364 0.311669946001854 no 2334 0.189131384128345 907 704353 SGTC_1923 st058458 19.1 µM -0.882885960050753 0.311306772440625 no 2335 0.188648945041672 928 3534982 SGTC_706 4262-0057 46.9 µM -0.883058910578271 0.3112715790073 no 2336 0.188602221558438 907 883298 SGTC_775 4577-0580 57.3 µM -0.88312422252088 0.311258289230577 no 2337 0.188584579053969 908 2006902 SGTC_1443 4112-3303 14 µM -0.883588732243259 0.311163777160016 no 2338 0.188459131895652 884 704433 SGTC_2377 9073351 62.6 µM -0.886824542316663 0.310505744585653 no 2339 0.187586686069554 925 7337946 YHR072W ERG7 SGTC_1559 coumarin 343 70.1 µM -0.892067751016513 0.309440775470053 no 2340 0.186178309514234 900 108770 A hepatotoxic, DNA x-linker. SGTC_3023 9089636 49.47 µM -0.892760028706627 0.309300283442858 no 2341 0.185992848007669 924 17249241 SGTC_2357 9067248 200 µM -0.894390455494969 0.308969511983473 no 2342 0.185556508695022 933 9150235 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.900517415353943 0.307727896153074 no 2343 0.183922480810362 915 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1260 0700-1617 7.75 µM -0.900800778595447 0.307670526265701 no 2344 0.183847126760183 881 2853078 SGTC_685 1278-0033 54.9 µM -0.901535670733369 0.307521761490681 no 2345 0.183651788423439 909 3590572 SGTC_2898 9056270 58.44 µM -0.902653891475844 0.307295459941634 no 2346 0.183354807460665 847 19154699 SGTC_1837 st055472 66.5 µM -0.903710436950191 0.307081707407684 no 2347 0.18307448170895 902 676091 SGTC_2351 9026858 72.31 µM -0.905404124475524 0.306739189736477 no 2348 0.182625665752771 938 1409300 SGTC_1960 st011366 51.8 µM -0.906174038483656 0.306583544301497 no 2349 0.182421871002109 899 3972846 SGTC_1096 rimcazole 32.2 µM -0.90875619612821 0.306061791354951 no 2350 0.181739416696759 893 18528119 A dopamine reuptake inhibitor. SGTC_3101 9120531 49.47 µM -0.910056168081456 0.30579926666473 no 2351 0.181396444418883 924 24824904 SGTC_1703 st026983 48.3 µM -0.910411139449081 0.305727598799953 no 2352 0.181302862616526 891 1104023 SGTC_1216 1165-0504 9.65 µM -0.912919718519579 0.305221334935522 no 2353 0.180642383002011 915 6304004 SGTC_950 1165-0508 94.1 µM -0.913487122643007 0.305106877017601 no 2354 0.180493201602705 912 6148369 SGTC_889 0919-1524 82.7 µM -0.914627330188603 0.304876929666086 no 2355 0.180193652985085 911 3905452 SGTC_941 3237-0776 460 µM -0.91616713289684 0.304566517644859 no 2356 0.179789620622285 904 760008 SGTC_588 3970-1144 52.9 µM -0.916704029044612 0.304458316705113 no 2357 0.179648877125731 878 1888707 SGTC_3115 9123671 49.47 µM -0.920271791196554 0.303739738884816 no 2358 0.178715373176662 925 3286988 SGTC_3177 9107506 49.47 µM -0.920710927671112 0.303651345375069 no 2359 0.178600684702195 902 8897194 SGTC_290 2043-6722 48.1 µM -0.921579004737782 0.303476644473757 no 2360 0.17837410700165 902 773758 YLR208W SEC13 SGTC_2742 clothiapine 36.27 µM -0.92199310310113 0.303393322811353 no 2361 0.1782660865864 890 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1081 sertraline 6 µM -0.923327207135167 0.303124954282579 no 2362 0.177918356771306 900 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1287 0971-0001 34.6 µM -0.926967465887953 0.302393220118509 no 2363 0.176971713210928 890 4665869 SGTC_2905 7799065 20.05 µM -0.926984771788239 0.302389743324862 no 2364 0.176967220453658 888 1296806 SGTC_275 trichlorophene 5.69 µM -0.929885736131695 0.301807186766446 no 2365 0.17621512450965 889 62616 SGTC_1060 3448-7350 82 µM -0.933149225269123 0.301152433502315 no 2366 0.17537146314342 928 570178 SGTC_3349 9149703 23.001 µM -0.939405374102083 0.299899056420126 no 2367 0.173761327432375 901 4910494 SGTC_1141 3253-0389 52.6 µM -0.939664220417202 0.299847249214967 no 2368 0.173694911753483 916 5402031 SGTC_2740 felodipine 17.08 µM -0.93968273381336 0.299843543977272 no 2369 0.173690162141477 895 3333 L-type calcium channel blocker SGTC_891 0929-0073 133 µM -0.94179326796711 0.299421281433674 no 2370 0.173149246248909 927 5603632 SGTC_2523 spermine 47.74 µM -0.942012099440398 0.299377514426073 no 2371 0.173093222648435 886 1103 A DNA binding polyamine. SGTC_677 0929-0063 136 µM -0.94256994343314 0.299265956937038 no 2372 0.172950459832813 940 1539583 SGTC_134 0269-0018 6.916 µM -0.944293339836546 0.298921431789607 no 2373 0.172509884213405 919 4378915 SGTC_1005 4092-0690 4.4 µM -0.94433313798898 0.298913477847253 no 2374 0.17249971852457 929 1529343 SGTC_3158 9100007 49.47 µM -0.944821635653303 0.298815855966251 no 2375 0.172374972117145 934 19297233 SGTC_1836 st055642 81 µM -0.948984373878137 0.29798455847041 no 2376 0.171314279797359 917 8571 SGTC_1319 1306-0155 43.7 µM -0.949810577042716 0.297819691411716 no 2377 0.171104255256311 920 3122360 SGTC_1160 4092-0570 10.5 µM -0.950080312702167 0.297765875252276 no 2378 0.171035722917538 926 4994975 SGTC_2832 7992762 51.95 µM -0.950129663016695 0.297756029631897 no 2379 0.17102318627371 910 2985177 SGTC_1273 0849-0096 14.1 µM -0.951062952698151 0.29756986190836 no 2380 0.170786209904172 922 5286025 SGTC_3269 9137823 49.47 µM -0.955292512946467 0.296726838268992 no 2381 0.169714896334344 868 17682936 SGTC_3283 9109332 35.8195 µM -0.963546533808869 0.29508482825558 no 2382 0.167636661722473 893 17027281 SGTC_850 0388-0143 75.9 µM -0.964306594162088 0.294933836634255 no 2383 0.167446117921031 919 67273 SGTC_6 0844-0013 19.835 µM -0.965109803290605 0.294774311891368 no 2384 0.167244908628108 939 1584900 SGTC_2447 5741742 33.78 µM -0.966123725013941 0.294572994509399 no 2385 0.166991137045452 915 1776504 SGTC_2097 5376186 200 µM -0.96645371928632 0.294507486783224 no 2386 0.166908597310175 919 742755 SGTC_1932 st074806 40.9 µM -0.966987767187293 0.294401486269663 no 2387 0.166775074476037 917 17251235 SGTC_495 decylubiquinone 155 µM -0.967160334532777 0.294367238000707 no 2388 0.166731943867252 934 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3182 9108849 49.47 µM -0.969332568677327 0.293936286856149 no 2389 0.166189642250252 909 17133045 SGTC_2386 9075165 157.42 µM -0.970891720114124 0.293627145618499 no 2390 0.16580110087041 917 16452277 SGTC_524 r073-0010 27.8 µM -0.974980989568335 0.292817060370899 no 2391 0.164784844967022 925 2772106 SGTC_1078 idebenone 36.1 µM -0.977172662837858 0.292383316884388 no 2392 0.164241839681892 939 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2979 9012552 45.46 µM -0.981436258229606 0.291540386249655 no 2393 0.163188826643141 936 17100905 SGTC_856 0433-0016 11.3 µM -0.982162446093742 0.291396928896525 no 2394 0.163009912645652 921 3911780 SGTC_2171 5739187 198.077 µM -0.983919064054011 0.291050047843318 no 2395 0.162577654691867 904 2262761 SGTC_2805 7950783 58.44 µM -0.984118722704269 0.291010633267076 no 2396 0.162528571137595 918 1178958 YDL195W SEC31 SGTC_2811 7967822 32.47 µM -0.98435091270009 0.290964799820581 no 2397 0.162471502291652 920 2232244 SGTC_1571 st070080 73.4 µM -0.984913204806055 0.290853819415548 no 2398 0.162333353293812 913 4315245 SGTC_959 1222-0044 107 µM -0.98554962411262 0.290728232295097 no 2399 0.162177084333158 907 6083612 SGTC_2284 7945075 39.21 µM -0.993337203305728 0.289193536455337 no 2400 0.160272826521326 915 1245402 SGTC_149 3970-0822 46.1 µM -0.994722851731204 0.288920866785557 no 2401 0.159935538541718 922 3114250 YBL034C STU1 SGTC_39 0986-0283 58.349 µM -0.994787670573576 0.288908114613361 no 2402 0.159919772020363 885 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_979 1426-2828 121 µM -0.994881015595769 0.288889750792172 no 2403 0.159897068583285 942 747872 SGTC_1605 st000082 49.1 µM -0.995791889043545 0.288710582963293 no 2404 0.159675636014847 909 1114022 SGTC_2367 9070478 135.38 µM -0.998180533550181 0.288240987853927 no 2405 0.159095912063317 917 572802 SGTC_2960 9079389 5.97 µM -0.998611749720705 0.288156251397759 no 2406 0.158991403024966 929 16457355 SGTC_1126 isoteolin 1.0172 µM -0.999123396409282 0.288055725130655 no 2407 0.158867459306656 911 133323 SGTC_817 1391-0715 46 µM -0.999342620237975 0.288012657987334 no 2408 0.158814372872355 928 1353946 SGTC_57 miconazole 162.5 nM -0.999827493912687 0.287917413974862 no 2409 0.158696998954713 892 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1865 st057639 52.2 µM -1.00075597609055 0.287735073208996 no 2410 0.158472398992216 936 688818 SGTC_201 4262-0159 12.803 µM -1.00513143733538 0.286876529744764 no 2411 0.157416782051732 950 1341029 SGTC_1259 0671-0132 43 µM -1.00521010345316 0.286861105165411 no 2412 0.157397845578426 923 X1259 SGTC_3193 9111931 49.47 µM -1.00567137961925 0.28677066764531 no 2413 0.157286837514472 956 17087244 SGTC_892 0929-0076 29 µM -1.00726252376168 0.286458812670038 no 2414 0.156904317021354 923 5751038 SGTC_2882 9058044 58.44 µM -1.00739002130748 0.286433830860184 no 2415 0.156873692364227 923 18076804 SGTC_2389 9091542 195.52 µM -1.00899774629379 0.286118902727298 no 2416 0.156487857516763 918 3626624 YOL127W RPL25 SGTC_1440 4100-1550 40 µM -1.00945469297775 0.286029424061986 no 2417 0.156378309889754 935 742806 SGTC_2330 7979373 200 µM -1.00961803647336 0.285997441592141 no 2418 0.156339162452934 916 1863007 SGTC_755 1995-0008 37.3 µM -1.01107839066171 0.285711581460502 no 2419 0.155989456036481 911 689533 SGTC_2628 lathosterol 100 µM -1.01211298874441 0.285509144156659 no 2420 0.155742016352181 939 6710616 SGTC_731 3966-0296 387 µM -1.01325097172698 0.285286556668063 no 2421 0.155470149690309 919 660956 SGTC_1100 amiodarone 5.07 µM -1.0133102695899 0.285274960375916 no 2422 0.155455991887241 923 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2994 9053520 71.4286 µM -1.01386694852246 0.285166107175767 no 2423 0.155323122155987 941 4647384 SGTC_1833 st055984 71 µM -1.01609555077535 0.284730523857588 no 2424 0.154791943785042 925 676288 SGTC_3337 9144342 33.5465 µM -1.01644410497989 0.284662427195857 no 2425 0.154708975946918 918 17682949 SGTC_183 3914-0051 30.55 µM -1.01761365667003 0.28443398996562 no 2426 0.15443079733951 924 1596232 SGTC_2888 9058547 12.99 µM -1.01790701819638 0.284376704235952 no 2427 0.15436107302226 922 16476514 SGTC_206 4546-0025 72.014 µM -1.01822006507176 0.284315580560708 no 2428 0.154286692975253 936 6620745 YIL048W NEO1 SGTC_3353 9151644 39.2805 µM -1.01947611506889 0.284070394854431 no 2429 0.153988493421206 931 4909158 SGTC_1600 coumarin 106 71.1 µM -1.02019055224924 0.283930979157354 no 2430 0.153819048737153 937 100336 A hepatotoxic, DNA x-linker. SGTC_114 0364-0001 490.298 µM -1.02052160932042 0.28386638758723 no 2431 0.153740573040334 949 4003655 SGTC_2842 9000675 19.48 µM -1.02132686831685 0.283709305243934 no 2432 0.153549800414624 907 2989072 SGTC_849 0386-0493 241 µM -1.02134954698737 0.283704881905203 no 2433 0.153544429917611 939 726119 SGTC_1430 4049-0248 69.1 µM -1.02152135209279 0.283671373422265 no 2434 0.15350374908638 939 22774488 SGTC_610 4215-0184 155 µM -1.0215473874291 0.283666295713993 no 2435 0.153497584938325 897 5605015 SGTC_1264 0783-0040 158 µM -1.0216628576226 0.283643775924426 no 2436 0.153470248094433 918 2855798 SGTC_317 4495-0002 170 µM -1.0219047181395 0.28359660940233 no 2437 0.153412999585581 923 15991618 SGTC_3242 9133940 49.47 µM -1.02283962388376 0.283414323742253 no 2438 0.15319183995384 948 17248444 SGTC_1820 st053765 18.6 µM -1.02370485027693 0.283245674054473 no 2439 0.152987351884822 937 3690829 SGTC_3164 9100705 49.47 µM -1.02498724915633 0.282995797804324 no 2440 0.152684602066346 906 17174235 SGTC_2143 5623677 140.463 µM -1.02549464909793 0.282896959824617 no 2441 0.152564924461919 896 5375313 SGTC_1222 0366-0074 1.18 µM -1.0264282196597 0.282715150092514 no 2442 0.152344891010916 945 286520 SGTC_599 1935-0052 86.5 µM -1.02837788282439 0.282335640896645 no 2443 0.151886054087009 934 9557311 SGTC_450 aminopyrene 156 nM -1.03129009562695 0.281769224715256 no 2444 0.151202400765005 929 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1968 st069590 43.6 µM -1.03187476485921 0.28165557445217 no 2445 0.151065394509568 930 6384066 SGTC_1246 0422-0085 105 µM -1.03208673975086 0.281614375414431 no 2446 0.151015742584507 932 264295 SGTC_1855 st056195 39.6 µM -1.03255977827846 0.281522447024226 no 2447 0.150904979599215 898 4028379 SGTC_2829 7992743 58.44 µM -1.03492611918383 0.281062799383241 no 2448 0.150351707811182 946 16462845 SGTC_1988 st071872 53.4 µM -1.03534509337242 0.280981453936513 no 2449 0.150253888900291 938 16414116 SGTC_2755 lomerizine 42.69 µM -1.03535945914758 0.28097866496788 no 2450 0.150250535640476 922 3949 A calcium channel blocker. SGTC_296 1222-0039 74.9 µM -1.0357970283655 0.280893721780068 no 2451 0.150148422111493 939 5984176 SGTC_2237 6667747 47.222 µM -1.03612354496877 0.280830344785548 no 2452 0.150072254569867 957 729940 YDL015C TSC13 SGTC_2552 juarezic acid 87.02 µM -1.03938243897571 0.280198171388828 no 2453 0.14931345397669 948 1549512 SGTC_2338 7999974 200 µM -1.04059370992974 0.27996338004663 no 2454 0.149032075870966 928 315925 SGTC_65 0798-0905 34.986 µM -1.04396037979487 0.279311290197156 no 2455 0.148251860379491 980 3602145 SGTC_2477 5967686 25.23 µM -1.04710981726106 0.278701944931025 no 2456 0.147524465991126 955 776118 SGTC_2321 7390090 138.78 µM -1.04756962352064 0.278613036939083 no 2457 0.147418469451492 964 649046 SGTC_395 anisomycin 6.25 µM -1.0484162749827 0.278449364821911 no 2458 0.147223429196741 954 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1449 4112-4002 201 µM -1.04929682319557 0.278279189601597 no 2459 0.147020763841501 937 2059539 SGTC_2444 5485484 36.41 µM -1.05165129586162 0.277824412145749 no 2460 0.146479782020222 970 6790631 SGTC_1242 0402-0103 60.1 µM -1.05307849356999 0.277548918957693 no 2461 0.14615250934381 939 432868 SGTC_2306 7482397 179.52 µM -1.05425413778103 0.277322083673929 no 2462 0.145883289943473 983 891448 SGTC_117 lucigenin 22.078 µM -1.05459029134965 0.277257241019723 no 2463 0.145806372978036 975 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2144 5628481 200 µM -1.05694964632216 0.276802339849134 no 2464 0.145267284384564 915 2818399 SGTC_2815 7968870 71.43 µM -1.05774833528981 0.276648429551632 no 2465 0.145085096293884 957 2977326 YHR190W ERG9 SGTC_1671 st016596 74.5 µM -1.06026147298917 0.276164412468582 no 2466 0.144512830741469 948 2829167 SGTC_2063 5246145 200 µM -1.06098073108535 0.276025963689389 no 2467 0.144349329077537 953 711240 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.0619461519427 0.275840185047281 no 2468 0.144130065779732 947 368090 SGTC_2288 7946289 167.31 µM -1.0633730936566 0.275565707212622 no 2469 0.143806394797711 956 1246052 SGTC_1350 1495-0454 146 µM -1.06435878929487 0.27537618325851 no 2470 0.143583097574157 934 1069057 SGTC_2568 diosmetin 100 µM -1.06447595535494 0.275353659500363 no 2471 0.143556570615041 948 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3168 9103419 49.47 µM -1.0686182456136 0.27455793739885 no 2472 0.142620861809602 950 16649256 SGTC_617 3770-0098 35 µM -1.07268854907614 0.273777150393453 no 2473 0.14170543990618 934 5962639 SGTC_526 4469-0568 170 µM -1.07300652421758 0.273716201005272 no 2474 0.141634094442953 945 2901964 SGTC_1395 3486-0190 4.35 µM -1.07489628974407 0.273354109803962 no 2475 0.141210581651558 960 6748079 SGTC_2944 9067346 25.62 µM -1.07533269365665 0.273270525740873 no 2476 0.14111290191797 944 6473075 SGTC_1175 0741-0056 27.6 µM -1.0755038660253 0.273237744702498 no 2477 0.141074601137213 945 765927 SGTC_604 1000-0114 314 µM -1.07886186333478 0.272595052453696 no 2478 0.140324655952694 961 1572745 SGTC_2551 apiole 73.87 µM -1.07955844710696 0.272461826256805 no 2479 0.1401694268275 931 10659 A possible DNA adduct former. SGTC_1888 azatryptophan 97.5 µM -1.07978812583141 0.272417905789855 no 2480 0.140118270011094 949 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_152 4469-0003 551.229 µM -1.08060111960877 0.272262468772013 no 2481 0.139937292148892 932 697280 SGTC_386 1509-0011 3.07 µM -1.08339620649249 0.271728410022241 no 2482 0.139316299378824 944 3107280 SGTC_2053 5265679 138 µM -1.08353552241967 0.271701804502023 no 2483 0.139285396277705 942 764595 SGTC_2363 9053361 176 µM -1.08395177106308 0.271622320156026 no 2484 0.139193091666021 956 6469797 YMR079W SEC14 SGTC_155 k072-0202 43.6 µM -1.08438716744506 0.271539191863175 no 2485 0.139096585530362 935 5857737 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.08643178930156 0.271148990851687 no 2486 0.138644001806977 960 6710655 SGTC_2970 9090938 41.86 µM -1.08734168851577 0.270975433236405 no 2487 0.138442915556834 952 17217104 SGTC_2595 hexamethylquercetagetin 100 µM -1.08824053733435 0.27080403785117 no 2488 0.138244466669109 966 386331 SGTC_1666 st014829 29 µM -1.08845126918861 0.270763862655236 no 2489 0.138197969122182 962 3858230 SGTC_1514 1189-1591 158 µM -1.08863698595119 0.270728458954604 no 2490 0.138156999943706 958 767698 YMR146C TIF34 SGTC_1040 k898-0338 155 µM -1.09025870062078 0.27041940524283 no 2491 0.137799601055422 951 20969351 SGTC_3167 9103034 49.47 µM -1.0918631182218 0.270113821478518 no 2492 0.137446635442813 954 5127859 SGTC_1849 st056239 19.2 µM -1.0919945839335 0.270088789654906 no 2493 0.137417740886077 936 5393181 SGTC_1327 1436-0082 2.18 µM -1.09630237078106 0.26926920498146 no 2494 0.136473236120289 960 15992205 SGTC_3039 9090270 49.47 µM -1.09691122289404 0.26915346756499 no 2495 0.136340101121904 929 17173750 SGTC_3273 9137859 49.47 µM -1.09693345958711 0.269149241038238 no 2496 0.136335240405084 1005 2377234 SGTC_2729 fluphenazine 10.66 µM -1.09754370175568 0.269033265348046 no 2497 0.136201893892954 942 3372 An atypical antipsychotic. SGTC_888 0916-0002 6.97 µM -1.10103660187591 0.268369927473593 no 2498 0.135440363712883 957 2802138 YIL048W NEO1 SGTC_2106 5357045 167.29 µM -1.10226577948401 0.268136689747104 no 2499 0.135173070983991 952 668842 SGTC_403 arphamenine a 50 µM -1.10496042742541 0.267625734726843 no 2500 0.134588368331013 958 5487158 An arginine aminopeptidase inhibitor. SGTC_2784 7567673 72.73 µM -1.10515527356138 0.267588807336929 no 2501 0.134546156723554 933 3471247 SGTC_1444 4112-3581 28 µM -1.10707905860877 0.267224348048063 no 2502 0.134129874350256 951 2877249 SGTC_1885 st057546 99.9 µM -1.10764983887118 0.267116262469738 no 2503 0.13400653521421 919 702008 SGTC_1151 3909-8316 15.3 µM -1.10837702244375 0.266978591619281 no 2504 0.133849512017657 976 800431 SGTC_1981 st071826 47 µM -1.1095546581485 0.266755716925051 no 2505 0.13359548949625 931 11838600 SGTC_2015 5119600 184 µM -1.11095524703769 0.26649076946825 no 2506 0.133293806580412 960 2828786 SGTC_3148 9097893 49.47 µM -1.11187331870028 0.266317171374298 no 2507 0.133096311026477 922 17174100 SGTC_1725 st036284 20.55 µM -1.11371064149848 0.265969924118647 no 2508 0.132701671287735 946 707914 SGTC_2984 9022109 38.96 µM -1.11544278925661 0.265642764747439 no 2509 0.132330360926519 989 6459207 SGTC_472 calcifediol 10 µM -1.11640104026651 0.265461862825126 no 2510 0.132125254217723 972 5283731 A vitamin D metabolite. SGTC_470 aa-861 153 µM -1.11753881774302 0.265247150478008 no 2511 0.13188200594372 941 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3091 9116372 49.47 µM -1.11809788281175 0.265141680465331 no 2512 0.131762595292123 970 17169793 SGTC_2904 7225135 42.03 µM -1.12225800135584 0.264357525843419 no 2513 0.130876378870839 985 4446116 SGTC_72 0744-0168 198.391 µM -1.12236709101674 0.264336979065794 no 2514 0.130853195416193 981 677577 SGTC_452 diindolylmethane 8 µM -1.12314502203895 0.264190481186681 no 2515 0.130687953798577 962 3071 Inhibits expression of several cancer promoting factors. SGTC_3190 9110366 49.47 µM -1.12316376607734 0.26418695187001 no 2516 0.13068397412691 957 17123768 SGTC_802 4112-3352 742 µM -1.12439290718779 0.263955569210418 no 2517 0.130423189853038 938 704594 SGTC_579 4491-1009 110 µM -1.1282298578349 0.263233938171474 no 2518 0.129611428664467 992 1271041 SGTC_2687 chenodiol 100 µM -1.1284183518878 0.263198513308052 no 2519 0.129571640468635 944 5702181 A cholesterol synthesis inhibitor. SGTC_381 3461-2219 42.7 µM -1.12878839763738 0.263128975385592 no 2520 0.12949355411399 991 2883159 SGTC_503 tyrphostin 8 294 µM -1.12995313879733 0.262910161899329 no 2521 0.129247985479762 992 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2478 5763493 32.33 µM -1.1314529202697 0.26262854332716 no 2522 0.128932254186588 948 1365576 YLR208W SEC13 SGTC_2657 nystatin 74.44 µM -1.13396389139528 0.262157396364972 no 2523 0.128404847351002 948 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.13613513786034 0.261750343218938 no 2524 0.127950005620863 976 6708784 An antioxidant flavonoid SGTC_2710 st078562 53.7235 µM -1.13665690021604 0.261652574474897 no 2525 0.127840871702057 977 17250908 SGTC_1186 1319-0216 26 µM -1.13672979450038 0.26163891690838 no 2526 0.127825629991034 957 4565136 SGTC_2594 a-mangostin 100 µM -1.13797738898593 0.261405222735881 no 2527 0.127564962020429 971 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2317 5986382 200 µM -1.14238772533524 0.26057995714366 no 2528 0.126646445571157 991 877883 SGTC_1368 1852-0141 284 µM -1.14239570720987 0.260578464785872 no 2529 0.12664478741647 981 2838987 SGTC_175 3793-3120 23.7 µM -1.14323330336338 0.260421885290434 no 2530 0.126470869221247 968 5322297 SGTC_209 4077-0173 175.592 µM -1.14448380392942 0.260188208017017 no 2531 0.126211525447211 957 15993494 SGTC_1470 k295-0292 231 µM -1.14530685369231 0.260034466180138 no 2532 0.126041033940292 983 5045612 SGTC_357 1325-0123 420 µM -1.14547865025553 0.260002381297747 no 2533 0.126005467226527 988 1098503 SGTC_2162 5663267 200 µM -1.14650587653225 0.25981057819056 no 2534 0.125792948552937 968 6456493 SGTC_1864 st057645 30.4 µM -1.14817706491018 0.259498690920613 no 2535 0.125447737653049 967 688666 SGTC_51 1013-0126 23.419 µM -1.14945914322777 0.259259552855354 no 2536 0.125183352303475 944 1627850 SGTC_748 act1.228 77.9 µM -1.15100902501111 0.258970615215261 no 2537 0.124864261340291 964 4421505 YNR035C ARC35 SGTC_1462 k081-0014 26.5 µM -1.15221256277 0.258746359908626 no 2538 0.124616868280461 889 3270634 SGTC_567 1080-0542 68.4 µM -1.15561905011048 0.258112174068071 no 2539 0.123918506193955 920 5950415 SGTC_2730 imipramine 71.33 µM -1.15644250973132 0.257958991624354 no 2540 0.123750101090134 949 3696 A tricyclic antidepressant. SGTC_2283 7944793 200 µM -1.15991914754906 0.257312777224638 no 2541 0.123040863068882 940 2970533 SGTC_2376 9072922 81.32 µM -1.16159710039898 0.257001191766449 no 2542 0.122699580226247 978 17087968 SGTC_2421 5690543 90.72 µM -1.16164242885272 0.256992777276694 no 2543 0.122690369983736 975 3397993 SGTC_3333 9141820 12.094 µM -1.16235417805477 0.256860671415865 no 2544 0.122545813972911 950 1939433 SGTC_2263 7948595 193.29 µM -1.16358724530641 0.256631888784739 no 2545 0.12229566138188 947 2971371 SGTC_173 1273-0061 2.693 µM -1.16442313544685 0.256476858551871 no 2546 0.122126288170914 935 2847414 YPL266W DIM1 SGTC_517 1365-0151 113 µM -1.1653567809523 0.256303755604166 no 2547 0.121937301971373 964 768657 SGTC_2810 7959871 45.46 µM -1.16669648194518 0.256055474190745 no 2548 0.121666482032059 948 2974535 SGTC_2339 9000433 200 µM -1.16848946130762 0.255723384925271 no 2549 0.121304693887232 963 2988954 SGTC_84 0443-0269 128.823 µM -1.16870910890576 0.255682718044752 no 2550 0.121260425369737 926 6150058 SGTC_3298 9116858 71.43 µM -1.16908505030375 0.255613121824986 no 2551 0.121184683239145 995 2506942 SGTC_1907 st060210 83.7 µM -1.17015972832345 0.255414226441871 no 2552 0.120968347922281 972 688793 SGTC_435 c-PAF 6.7 µM -1.17046586078867 0.255357583965441 no 2553 0.120906772466203 952 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1232 0279-0259 161 µM -1.17071084618658 0.255312260018214 no 2554 0.120857512016123 956 1560000 SGTC_2100 5377183 190 µM -1.17085149118258 0.25528624164769 no 2555 0.120829238199995 943 2844202 SGTC_380 3970-0968 6 µM -1.17140883863414 0.255183149780225 no 2556 0.120717240607394 966 2891601 SGTC_424 splitomicin 100 mM -1.17304536361966 0.254880569637065 no 2557 0.12038880733743 988 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1093 fluphenazine 7.97 µM -1.17424396187702 0.254659077766152 no 2558 0.120148660964097 989 6602611 An atypical antipsychotic. SGTC_2122 5258151 111.688 µM -1.17521533127479 0.25447965004173 no 2559 0.119954289044193 975 2173356 SGTC_62 0180-0423 3.232 µM -1.17665807914473 0.254213273356976 no 2560 0.119666003128681 978 30102 YGL099W LSG1 SGTC_2754 granisetron 64.02 µM -1.17827459311601 0.2539149877556 no 2561 0.11934357660957 990 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1691 st019933 84.6 µM -1.17881770984367 0.253814810932685 no 2562 0.11923538538916 995 6176082 SGTC_2189 6047310 154.431 µM -1.18067956106189 0.253471553640305 no 2563 0.118865022001558 967 711535 SGTC_607 4491-0986 66.8 µM -1.18075787767677 0.253457120268053 no 2564 0.11884946092202 928 698981 YDR232W HEM1 SGTC_1267 0828-0272 9.49 µM -1.18377803305431 0.252900849917902 no 2565 0.118250470015207 970 745334 SGTC_1656 st012921 11 µM -1.18379847502692 0.252897086983236 no 2566 0.118246423021061 960 6732821 SGTC_948 3448-0295 75.3 µM -1.18545562637727 0.252592138531465 no 2567 0.117918674620833 949 678569 SGTC_561 1550-0330 72.9 µM -1.18690727243507 0.252325166345617 no 2568 0.117632099217077 974 6812934 SGTC_387 norethindrone acetate 66.7 µM -1.18847109196249 0.252037730868691 no 2569 0.117323931172136 992 541197 SGTC_2940 9060638 45.86 µM -1.18927541939801 0.25188995999004 no 2570 0.117165652359743 950 4027022 SGTC_2868 9035608 32.47 µM -1.18965922748136 0.251819462964907 no 2571 0.117090178387578 970 6462614 SGTC_1948 st076329 66.6 µM -1.19593895743167 0.250667496991614 no 2572 0.115860190524417 973 24208413 SGTC_811 0416-0114 265 µM -1.1961501268375 0.250628808226609 no 2573 0.115818989592444 952 6612453 SGTC_2787 5284540 71.43 µM -1.19777272367017 0.25033163460612 no 2574 0.115502754368754 976 736958 SGTC_130 0136-0219 337.655 µM -1.19907286964332 0.250093651744463 no 2575 0.115249806169449 982 234244 SGTC_782 0083-0095 30.5 µM -1.19959179077132 0.249998700289946 no 2576 0.115148958177291 975 3591729 An indicator and reagent. SGTC_2481 5478948 45.16 µM -1.19995882038454 0.249931553281672 no 2577 0.115077666926357 978 77792 SGTC_1617 st002906 78 µM -1.20441488410557 0.249117093414661 no 2578 0.114214631014631 980 5150859 SGTC_3125 9127534 49.47 µM -1.20450243038065 0.249101106242086 no 2579 0.114197721632052 963 1639235 SGTC_705 1124-0212 310 µM -1.2054505530317 0.248928000771632 no 2580 0.114014707900913 953 9554485 SGTC_2082 5219693 150 µM -1.20714755975612 0.248618326147263 no 2581 0.113687660851534 957 2834649 SGTC_2922 7999257 32.47 µM -1.20727110093654 0.248595790016616 no 2582 0.113663878141949 994 2988377 SGTC_848 0368-0089 85.6 µM -1.20785145426519 0.248489937708734 no 2583 0.113552202740834 968 762535 SGTC_690 glyoxal 20.3 µM -1.20822830431651 0.248421215810505 no 2584 0.113479728684003 970 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2160 5660466 132.927 µM -1.20953558862085 0.248182899637317 no 2585 0.113228573519417 988 2859134 SGTC_1372 2752-0194 270 µM -1.20983158957696 0.248128955994688 no 2586 0.113171760986006 967 823334 SGTC_1077 5-fluorocytosine 377 nM -1.21199501405829 0.247734880355515 no 2587 0.112757144609505 978 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_974 1326-0144 138 µM -1.21280947349488 0.247586610242723 no 2588 0.112601336294053 985 5411856 SGTC_377 3970-0964 33.1 µM -1.21522498237381 0.24714715237982 no 2589 0.112140147298828 985 16481235 SGTC_1473 k844-0725 134 µM -1.21739210944854 0.246753238389857 no 2590 0.111727531883303 974 54682906 SGTC_2120 5538279 151.968 µM -1.21746317045664 0.246740327478996 no 2591 0.111714020463831 986 2058197 SGTC_650 1328-0195 38 µM -1.21759528624152 0.246716324627806 no 2592 0.111688903299446 982 2780821 SGTC_781 4335-2806 94.4 µM -1.2215570271134 0.245997135144158 no 2593 0.110937593857849 1016 845254 SGTC_2966 9084041 48.03 µM -1.22299659648303 0.245736083681867 no 2594 0.110665490902743 986 17741380 SGTC_821 1114-0266 29.2 µM -1.22309802425587 0.245717696383575 no 2595 0.110646337391513 961 3123235 SGTC_496 calpeptin 138 µM -1.22397442263653 0.245558849583436 no 2596 0.110480938216019 971 73364 A calpain inhibitor. SGTC_543 3844-1095 191 µM -1.22428441985764 0.245502675940235 no 2597 0.110422476133494 983 4230703 SGTC_1555 citronellol 128 µM -1.22604124817847 0.245184456954006 no 2598 0.110091576562591 992 8842 A terpine precursor. SGTC_1289 0976-0073 69.1 µM -1.22673155698606 0.245059480207605 no 2599 0.109961751390241 987 3391136 SGTC_1782 st039423 80.636 µM -1.22708320948537 0.244995828565203 no 2600 0.10989565896955 996 2068169 SGTC_1939 st074455 53.6 µM -1.22825789905364 0.244783265767003 no 2601 0.109675084979253 986 1644229 SGTC_289 k017-0060 526 µM -1.23028098468262 0.244417416578474 no 2602 0.109295951232138 989 5512909 SGTC_820 1582-0060 59.9 µM -1.23078226867809 0.244326811341316 no 2603 0.109202154480211 981 3848840 SGTC_2441 5730946 39.09 µM -1.23090179715354 0.244305209682502 no 2604 0.109179797690987 952 1774275 SGTC_750 4073-0104 132 µM -1.23186302878188 0.244131529533933 no 2605 0.109000127019627 924 22330957 SGTC_1011 4112-3381 17.4 µM -1.23274344133473 0.24397251062115 no 2606 0.108835749380283 970 2877139 SGTC_3202 9113761 49.47 µM -1.23584172226272 0.243413347971304 no 2607 0.108258701476779 980 4798415 SGTC_2634 4'-methoxyflavone 100 µM -1.23624876792242 0.243339937849165 no 2608 0.108183054088824 983 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2278 7948257 134.34 µM -1.23635224865802 0.243321277149184 no 2609 0.108163828782295 969 1247028 SGTC_2131 toluylene red 5.2905 µM -1.23675176942935 0.243249238752928 no 2610 0.108089626360236 942 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3234 9132280 49.47 µM -1.23712082390282 0.243182704041266 no 2611 0.108021114969022 971 17612295 SGTC_1129 3453-1384 223 µM -1.2373417623386 0.243142877028287 no 2612 0.107980114851909 990 1084452 SGTC_18 0111-0177 500 nM -1.23759723594952 0.243096829000144 no 2613 0.107932719924428 989 721752 SGTC_958 1222-0007 33 µM -1.23837302430086 0.24295702536969 no 2614 0.107788889121538 973 7312461 SGTC_1322 1348-1070 12 µM -1.23922935494171 0.242802757853171 no 2615 0.107630286180359 970 6758089 SGTC_2748 diazoxide 86.69 µM -1.23952810684171 0.242748950331045 no 2616 0.107574993247025 936 3019 A potassium channel activatior. SGTC_2033 5192550 145 µM -1.24180750437411 0.242338625817442 no 2617 0.107153796638431 956 182073 SGTC_1974 st069448 26.9 µM -1.24228083813317 0.242253466047548 no 2618 0.107066481367567 974 6323587 YNR016C ACC1 SGTC_1292 0kpi-0043 232 µM -1.24264623202462 0.242187737357253 no 2619 0.106999112730906 983 3333905 SGTC_2415 st077333 57.7 µM -1.24462327813541 0.241832265172175 no 2620 0.10663512979021 946 2766255 SGTC_2398 5228213 48.84 µM -1.24522419297025 0.241724277028232 no 2621 0.106524676011621 992 80771 YMR134W ERG29 SGTC_2896 9052656 71.43 µM -1.24614526696591 0.24155880510387 no 2622 0.106355534343137 948 6469436 SGTC_1261 0712-0010 12.7 µM -1.24697563057717 0.241409682133559 no 2623 0.106203216608703 985 2840123 SGTC_3194 9111903 49.47 µM -1.24870418481521 0.241099415777614 no 2624 0.105886644845431 994 17087251 SGTC_1501 4491-0275 38.4 µM -1.24952413533561 0.240952314836842 no 2625 0.105736715764651 991 5104718 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.25116159810047 0.240658696526104 no 2626 0.105437762840767 968 1241132 A phosphatase inhibitor. SGTC_1071 trifluoperazine 6.31 µM -1.25413469770233 0.240126079407447 no 2627 0.104896525272895 1008 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1830 st055982 50.3 µM -1.25514725706837 0.239944830843853 no 2628 0.104712653996009 992 455313 An antimicrobial agent. SGTC_1323 1348-1351 11.2 µM -1.25647047938654 0.239708085978058 no 2629 0.104472721229854 979 6989654 SGTC_2048 5246248 200 µM -1.2585306317266 0.239339746835808 no 2630 0.104099958182304 965 677046 SGTC_2688 kanamycin b 96.69 µM -1.25884891752233 0.239282867407432 no 2631 0.104042453797477 960 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3174 9107204 49.47 µM -1.25919591568312 0.239220865336056 no 2632 0.103979788224182 995 3938802 SGTC_2148 5546263 113.568 µM -1.26136371956903 0.238833718188148 no 2633 0.103588916719842 1006 792097 SGTC_2456 5770359 74.46 µM -1.26260827121784 0.238611609198452 no 2634 0.10336499695358 987 3118787 SGTC_2114 5491910 81.25 µM -1.26387515053318 0.238385631655563 no 2635 0.103137421096603 985 2849228 SGTC_283 0987-0079 11.7 µM -1.26395311282428 0.238371729087375 no 2636 0.103123428235713 990 411556 SGTC_735 3076-0345 636 µM -1.26415013904449 0.238336596510711 no 2637 0.103088071637504 978 2888990 SGTC_1705 st027868 56.3335 µM -1.26501722943256 0.238182015673631 no 2638 0.102932575830986 949 292948 SGTC_2123 5259487 200 µM -1.26572157126737 0.238056489336221 no 2639 0.102806391293505 989 2173474 SGTC_37 0566-0070 1.56 µM -1.26604606610368 0.237998670743773 no 2640 0.102748295098487 975 1626686 SGTC_1112 tnp00069 1.16933 µM -1.26690452172225 0.237845747977643 no 2641 0.102594715861946 986 145826 SGTC_1438 4092-1045 4 µM -1.27128561785243 0.237066152215906 no 2642 0.101813528487493 979 1351342 SGTC_2859 9028643 45.46 µM -1.27513913766539 0.236381598589936 no 2643 0.101129999395594 945 17151580 SGTC_3106 9121286 49.47 µM -1.27534426745318 0.236345189100147 no 2644 0.101093707891827 957 15943471 SGTC_1631 benzylvanillin 81.9 µM -1.27545154103552 0.236326149816705 no 2645 0.101074732860473 955 75506 SGTC_2798 7813637 45.45 µM -1.27641126666681 0.23615585199752 no 2646 0.100905087785533 980 956368 SGTC_2512 diallyl trisulfide 49.23 µM -1.27987349051324 0.235542062345652 no 2647 0.100294816123837 1014 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.28202728939109 0.235160677281984 no 2648 0.0999165367065243 988 6857784 SGTC_1880 MG-132 525 µM -1.28536084490388 0.234571059197071 no 2649 0.0993331085770693 969 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1245 0418-0076 17.2 µM -1.28618947609674 0.234424623177038 no 2650 0.0991884714870009 1012 6790114 SGTC_265 mycophenolic acid 32.932 µM -1.287490700458 0.23419477242871 no 2651 0.0989616544420237 1012 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_336 4111-0029 111 µM -1.29017609050307 0.233720814719341 no 2652 0.0984947628146893 999 3131175 SGTC_3165 9101544 49.47 µM -1.29163013111378 0.233464405992769 no 2653 0.0982426320922633 996 5002184 SGTC_320 4092-0846 5.34 µM -1.29185143607866 0.233425394273624 no 2654 0.0982042992885269 981 1359356 SGTC_1519 esterone 74 µM -1.29207957645714 0.233385181391202 no 2655 0.0981647939755702 1001 698 A steroid. SGTC_1471 k673-0312 37 µM -1.29228896193063 0.233348277701771 no 2656 0.098128546552203 992 24099884 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.29302505071589 0.233218569514177 no 2657 0.0980011975765884 991 616764 SGTC_1796 st049173 110.4 µM -1.29414005811142 0.23302216730173 no 2658 0.0978085235256827 989 94134 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.29606703960212 0.232682957108952 no 2659 0.0974761946614414 1010 75037 A free radical scavenger. SGTC_2156 5649887 115 µM -1.29669611123608 0.232572279892901 no 2660 0.0973678839538171 1014 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3043 9092303 49.47 µM -1.29820588736654 0.232306773289785 no 2661 0.097108297800532 987 25236084 SGTC_2610 ononetin 44.17 µM -1.29850559709016 0.23225408692717 no 2662 0.0970568271336139 1008 259632 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.30237943239043 0.231573699051084 no 2663 0.0963933549953554 1007 5282362 SGTC_190 3970-0790 3.722 µM -1.30352600389171 0.231372532236729 no 2664 0.0961976222710045 991 2832352 SGTC_552 k242-0005 476 µM -1.30452902652516 0.231196631125258 no 2665 0.0960266346829469 1006 4088318 SGTC_20 0481-0013 4.944 µM -1.3051373104737 0.231089992098741 no 2666 0.095923048031716 980 182045 SGTC_2908 7930301 100 µM -1.30865632943693 0.230473607509065 no 2667 0.0953253953955435 990 2223178 SGTC_2328 6201408 200 µM -1.3096990733611 0.230291139147151 no 2668 0.0951488285949227 1007 2890418 SGTC_1013 4112-3890 241 µM -1.31330181881242 0.229661321715248 no 2669 0.0945406329556528 991 705171 SGTC_2474 5321570 43.32 µM -1.31404732858732 0.229531115285644 no 2670 0.0944151387877238 1007 2841384 SGTC_1055 3448-0672 86 µM -1.31585216274415 0.229216064723877 no 2671 0.0941118337162284 987 748378 SGTC_2717 st081029 62.2815 µM -1.31600266742216 0.229189803692976 no 2672 0.0940865736900461 979 5292846 SGTC_43 0570-0105 72.5 µM -1.31906405367023 0.228655999548735 no 2673 0.0935738496377465 985 1114046 YDL195W SEC31 SGTC_1251 0490-5699 265 µM -1.32151950632034 0.22822835515505 no 2674 0.0931641014218737 997 3883818 SGTC_2627 acetyl isogambogic acid 100 µM -1.32281173053425 0.228003480629295 no 2675 0.0929489976079537 1000 6857789 A caspase activator and apoptosis inducer. SGTC_2602 kawain 100 µM -1.32359721142877 0.227866851154845 no 2676 0.0928184258970353 976 5369129 SGTC_1670 st016595 4.04 µM -1.32519995648208 0.227588206660601 no 2677 0.0925524199038253 1010 597879 SGTC_2074 5212007 75.395 µM -1.32813002080808 0.227079298015492 no 2678 0.0920675787115726 979 758611 SGTC_3355 9151058 44.0485 µM -1.32886839526695 0.226951154624135 no 2679 0.091945696206919 1004 17015728 SGTC_104 0074-0074 590.992 µM -1.33133114666038 0.226524044095952 no 2680 0.0915400369991637 992 3943124 SGTC_50 0929-0078 56.389 µM -1.33213749124368 0.226384299889007 no 2681 0.0914075062730863 955 1377751 SGTC_3265 9137266 49.47 µM -1.33397022689799 0.226066857303574 no 2682 0.091106807111251 966 17224265 SGTC_97 0535-0701 19.132 µM -1.33399967831334 0.226061758168073 no 2683 0.0911019809783357 961 2832013 YGL099W LSG1 SGTC_3225 9130819 49.47 µM -1.33571611105105 0.225764692137143 no 2684 0.0908210406787757 995 4547121 SGTC_1767 st044992 70.3 µM -1.33634520501614 0.2256558690602 no 2685 0.0907182337086242 989 9600693 SGTC_793 0488-0545 106 µM -1.33884355808899 0.22522398750101 no 2686 0.0903108036306504 1001 292548 SGTC_1233 0325-0408 14.2 µM -1.34063661674932 0.224914316521273 no 2687 0.0900192313279524 998 12874 SGTC_3024 9090631 49.47 µM -1.34537699754374 0.22409679053753 no 2688 0.089251759843407 987 25236383 SGTC_2879 9041815 71.43 µM -1.34539370743675 0.2240939117382 no 2689 0.0892490631360439 1001 4942971 SGTC_2165 5727197 32.143 µM -1.34542986807364 0.224087682014558 no 2690 0.0892432275997238 996 1361712 SGTC_1668 st014914 51.6 µM -1.34549920545465 0.224075736904929 no 2691 0.0892320388562441 1013 2839556 SGTC_987 1497-1013 404 µM -1.34754233320744 0.223723919096761 no 2692 0.0889028144375474 1008 1676435 SGTC_150 3970-0969 77.2 µM -1.35188864357686 0.222976548721138 no 2693 0.0882054705043261 998 6615640 SGTC_935 2996-0153 430 µM -1.35407379737095 0.222601338156137 no 2694 0.0878564174139969 1011 23738523 SGTC_739 1486-1183 203 µM -1.35483782057487 0.222470233476513 no 2695 0.0877346169240035 1002 4346692 SGTC_1628 st004252 77.7 µM -1.35824022566716 0.221886923322946 no 2696 0.0871937351881716 988 692968 SGTC_1715 st032160 10.2275 µM -1.35976134975464 0.221626423797899 no 2697 0.0869527284602703 990 5289825 SGTC_3328 9140624 29.0385 µM -1.37021760135084 0.219840479053447 no 2698 0.085309492731582 1017 4904392 SGTC_1116 jasmonic acid  1.58368 µM -1.37040376974192 0.219808756216726 no 2699 0.0852804479923565 1002 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2800 7887935 81.82 µM -1.3725603356208 0.219441471933586 no 2700 0.0849445348936521 1030 2961002 SGTC_3160 9100216 49.47 µM -1.37378022298659 0.219233869401363 no 2701 0.0847549613534736 1003 17191039 SGTC_2172 5754775 163.918 µM -1.37490670025227 0.219042263859369 no 2702 0.0845801858842997 988 2263357 SGTC_2203 7227154 166.4 µM -1.37557387325093 0.218928828036785 no 2703 0.0844768000513324 1007 896304 SGTC_2065 5221596 34.26 µM -1.37569046686803 0.218909007722975 no 2704 0.0844587423174275 987 788581 SGTC_2350 9023895 38.85 µM -1.37632421800314 0.21880129135358 no 2705 0.0843606391430599 979 2997209 SGTC_3292 9120825 59.784 µM -1.37667444087027 0.218741778336488 no 2706 0.0843064621690482 990 24824900 SGTC_458 nppb 133 µM -1.37713202634544 0.2186640353392 no 2707 0.0842357163163635 1015 4549 A chloride channel blocker. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.37963209274355 0.218239559221086 no 2708 0.0838499754860599 995 6312947 SGTC_2295 7971645 200 µM -1.38070669638308 0.218057252634393 no 2709 0.0836845807599102 1020 2978226 YKL099C UTP11 SGTC_2437 5741531 144.16 µM -1.38186347744174 0.21786110279337 no 2710 0.0835068119742211 980 2262990 SGTC_1507 4075-3230 155 µM -1.38394363615326 0.217508636354468 no 2711 0.0831878569888951 998 659771 SGTC_2593 nobiletin 86.24 µM -1.38457477314666 0.21740176030311 no 2712 0.0830912648216631 990 72344 An anti-infammatory. SGTC_2852 9023854 51.95 µM -1.38498282835114 0.217332676820993 no 2713 0.0830288590491071 1009 19798528 SGTC_3316 9136639 10.545 µM -1.38813246767896 0.216799871642665 no 2714 0.0825483557863866 983 4903665 SGTC_70 0141-0289 43.283 µM -1.388425909386 0.216750270397498 no 2715 0.0825036956668121 977 352408 SGTC_2249 haloperidol 116.36 µM -1.39286636957453 0.216000488800061 no 2716 0.081830101914678 985 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1056 3448-1962 115 µM -1.39301746059865 0.215975003204395 no 2717 0.0818072553596291 991 715507 SGTC_2840 9008771 71.43 µM -1.39342015783523 0.215907085912566 no 2718 0.0817463867772089 989 2992978 SGTC_720 r052-1644 49.9 µM -1.39815584717472 0.215109312669119 no 2719 0.081033136158349 1011 1422863 YOR257W CDC31 SGTC_3345 9148410 3.559 µM -1.39821039555739 0.215100133440652 no 2720 0.0810249479795049 977 4903596 SGTC_2745 rifampicin 24.3 µM -1.40004463164601 0.214791606433273 no 2721 0.0807499768593024 999 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2161 5662504 8.5105 µM -1.40023127661682 0.214760226303335 no 2722 0.0807220363779049 958 2859334 SGTC_2881 9058953 51.95 µM -1.40070088478268 0.214681284096371 no 2723 0.0806517690097374 980 17122249 SGTC_756 0508-1999 28.3 µM -1.40074115992498 0.214674514538063 no 2724 0.0806457448004148 1007 6753853 SGTC_3217 9129673 49.47 µM -1.40136947161227 0.214568922221183 no 2725 0.0805518082231693 1018 17248312 SGTC_3224 9130643 49.47 µM -1.40275724769431 0.214335803444967 no 2726 0.0803446198248957 1003 17644395 SGTC_963 1269-2853 151 µM -1.40308240651368 0.214281204539895 no 2727 0.0802961334325514 1009 3668223 SGTC_1998 st075797 76.8 µM -1.40422349975546 0.214089662379212 no 2728 0.0801261530933017 996 24208315 SGTC_2443 5493264 126.67 µM -1.40496749001031 0.213964830996796 no 2729 0.080015472869881 1023 5340055 SGTC_471 1-acyl-paf 4 µM -1.40536727936208 0.213897769320827 no 2730 0.0799560456973602 1014 16759367 SGTC_359 0081-0058 15.9 µM -1.40852826204195 0.213367969161542 no 2731 0.0794873521710941 1009 3494159 SGTC_369 0957-0393 4.5 µM -1.40904039737871 0.213282204195324 no 2732 0.0794116116158441 1007 6997992 SGTC_909 3448-9333 149 µM -1.41029695396305 0.213071859585771 no 2733 0.0792260087922762 1015 3344074 SGTC_2857 9024691 58.44 µM -1.4103912704583 0.213056076111071 no 2734 0.0792120908014516 1012 16478292 SGTC_1698 5-fluorocytosine 1.055 µM -1.41336809537684 0.212558267395485 no 2735 0.0787737607091253 994 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3150 9097574 49.47 µM -1.41460624140787 0.212351414824227 no 2736 0.0785919889048096 1003 17217476 SGTC_1117 retinoic acid 1.10837 µM -1.41541415235611 0.212216503514237 no 2737 0.0784735512851868 1029 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1792 st045773 43.6 µM -1.41560208906196 0.21218512755294 no 2738 0.078446019667356 979 2919270 SGTC_1744 st037937 38.9 µM -1.4171416022718 0.211928208524035 no 2739 0.0782207656995429 1032 1016152 SGTC_1965 Pectolinarigenin 58.4 µM -1.41938844133655 0.211553575396308 no 2740 0.0778929001905088 1020 5320438 An anti-inflammatory. SGTC_3348 9149464 3.537 µM -1.42780773606734 0.210153213128991 no 2741 0.0766736027756047 999 1951442 SGTC_997 3996-0078 137 µM -1.43251798416816 0.20937214919138 no 2742 0.0759978174966576 1003 735687 SGTC_3045 9092950 49.47 µM -1.43258091126433 0.20936172605545 no 2743 0.0759888200632508 1012 44120432 SGTC_1616 st002734 56.1 µM -1.43918848386716 0.208268959482482 no 2744 0.0750485636667321 1014 4026101 SGTC_903 1134-0042 114 µM -1.43945446225429 0.208225042296363 no 2745 0.0750109016010468 997 701009 SGTC_570 0987-0065 62.6 µM -1.44173048636539 0.207849458658718 no 2746 0.074689209863822 978 3104428 SGTC_1922 5578187 25 µM -1.44267536196656 0.207693655313921 no 2747 0.0745559714445371 976 1350412 SGTC_1352 1496-0991 99 µM -1.44302789590838 0.207635542623014 no 2748 0.0745063065683199 1026 3000039 SGTC_3259 9138485 49.47 µM -1.44303260344396 0.207634766684556 no 2749 0.07450564354303 1008 17646153 SGTC_2394 5221648 200 µM -1.44513035303212 0.20728916720019 no 2750 0.0742106373255451 1020 788586 SGTC_2924 9010168 62.78 µM -1.44667197723482 0.207035405088685 no 2751 0.0739944082670419 1030 2993929 SGTC_350 k064-0020 19.8 µM -1.44700972554287 0.206979833913767 no 2752 0.0739470998507129 964 2790705 SGTC_1355 1499-0035 1.68 µM -1.44817960234097 0.206787417323129 no 2753 0.0737834138283239 1023 1548538 SGTC_1328 1441-0025 69.2 µM -1.44860218878408 0.206717938062506 no 2754 0.0737243548010088 1007 4562601 SGTC_1426 4048-4480 71.7 µM -1.4503060318316 0.206437942125831 no 2755 0.0734865988846506 1018 14224343 SGTC_867 0518-0118 155 µM -1.45122687688559 0.206286711397877 no 2756 0.0733583475823137 992 6848158 SGTC_1882 5615643 20 µM -1.45696185607726 0.205346332524502 no 2757 0.0725634548466123 962 2253075 SGTC_2667 digitoxin 100 µM -1.45702009715914 0.205336795667852 no 2758 0.0725554163579036 983 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1819 st053448 58.6 µM -1.45739921465648 0.205274722392589 no 2759 0.0725031068756708 1035 2857616 SGTC_753 1322-0200 289 µM -1.45835806818448 0.205117778134778 no 2760 0.0723709361091218 1026 5403907 SGTC_2621 lithochol-11-enic acid 100 µM -1.45995787836318 0.20485608148754 no 2761 0.0721508253534375 1025 6708711 SGTC_3072 9116419 49.47 µM -1.46077133881406 0.204723091957772 no 2762 0.0720391019267739 1011 17170162 SGTC_1594 piperine 70.1 µM -1.46103683864774 0.204679697526402 no 2763 0.0720026659993091 1018 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1460 k062-0059 9.15 µM -1.46295751863493 0.204365936360293 no 2764 0.0717395017580443 1004 1373085 SGTC_1209 2323-2347 50.3 µM -1.46483079933286 0.204060194304151 no 2765 0.071483543305592 977 5412760 SGTC_2145 5634607 200 µM -1.46508585300492 0.204018587547689 no 2766 0.0714487479463457 1024 308662 SGTC_2884 9058502 51.95 µM -1.46783666108139 0.203570171133931 no 2767 0.0710742982342516 1013 6471554 SGTC_3300 9124615 50.48 µM -1.4689146541514 0.203394605097663 no 2768 0.0709279697027223 1013 24824903 SGTC_101 0490-5701 117.494 µM -1.46917177053545 0.203352743496118 no 2769 0.0708931025107578 999 4661669 SGTC_1345 1488-0192 31.4 µM -1.47046510101375 0.203142251911938 no 2770 0.0707179154420479 1020 658348 SGTC_596 1155-0152 116 µM -1.47173157667905 0.202936257090587 no 2771 0.0705466885316199 1014 280313 SGTC_3255 9139072 49.47 µM -1.47345251228435 0.202656543476514 no 2772 0.0703145298002295 1016 17646060 SGTC_1554 st069299 38.7 µM -1.47545224225644 0.20233180539522 no 2773 0.070045499451858 1010 24207999 SGTC_2314 7727897 200 µM -1.47634456673699 0.202187000438238 no 2774 0.0699257078850167 986 900724 SGTC_665 3914-0008 307 µM -1.47647281456625 0.202166193687413 no 2775 0.0699085040088886 1028 1069549 SGTC_1123 mangostin 811.285 nM -1.47685514622409 0.202104172329749 no 2776 0.0698572352455635 981 5281650 An antioxidant. SGTC_3191 9110352 49.47 µM -1.48038867293332 0.201531507151346 no 2777 0.0693847755574245 995 17122424 SGTC_656 4090-1979 187 µM -1.4806851711524 0.201483499070761 no 2778 0.0693452436592652 1021 22330961 SGTC_2445 5742597 35.57 µM -1.48080824970643 0.201463572582438 no 2779 0.0693288387791349 1016 1774255 SGTC_1338 1486-1223 76 µM -1.48247591725878 0.201193692676826 no 2780 0.0691068534649334 1011 3444526 SGTC_629 3448-6466 76.7 µM -1.48315628394776 0.201083650710204 no 2781 0.0690164464740544 1030 573744 SGTC_1757 st041620 31.8375 µM -1.48558062714182 0.20069183295755 no 2782 0.0686950412123227 1036 5289815 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.49037096451858 0.199918976469352 no 2783 0.0680633613210937 992 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1303 1160-0052 261 µM -1.4905647117328 0.199887755667046 no 2784 0.0680379074313397 1008 3562476 SGTC_233 rapamycin 362 pM -1.49075407234094 0.199857244564493 no 2785 0.068013036941992 1027 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2932 9016711 44.54 µM -1.49098164036573 0.199820580922379 no 2786 0.0679831576044134 1025 7117328 SGTC_2393 9031399 185.94 µM -1.49208394489101 0.199643045141863 no 2787 0.0678385701155889 1027 1526623 YDL150W RPC53 SGTC_727 3032-0951 202 µM -1.49390778834944 0.199349507730722 no 2788 0.0675998612552048 1025 3652836 SGTC_1975 st070967 30.8 µM -1.49543753845992 0.199103503506082 no 2789 0.0674001449119068 1014 261391 SGTC_3257 9139206 32.98 µM -1.49608082719159 0.199000108745642 no 2790 0.0673162967653764 1026 4910041 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.49805674834316 0.198682724504849 no 2791 0.067059253565025 1019 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.49885814811276 0.198554085949681 no 2792 0.0669552178713417 1029 5393153 SGTC_1961 st076550 68.7 µM -1.50002736933859 0.198366495817733 no 2793 0.0668036565306929 1022 1579337 SGTC_1492 4158-0558 28.5 µM -1.50038139198838 0.198309717440222 no 2794 0.0667578184237273 986 3967268 SGTC_3119 9125183 49.47 µM -1.50190038201618 0.198066212201054 no 2795 0.0665614189839255 1006 22695334 SGTC_2999 9069765 71.4286 µM -1.50760847537191 0.197152778246675 no 2796 0.0658273811504361 1007 2097066 SGTC_1241 0364-0022 50.8 µM -1.50774547809819 0.197130885843565 no 2797 0.0658098405650595 1026 4563895 SGTC_3319 9138450 16.7555 µM -1.51097226461167 0.196615685691681 no 2798 0.0653977587319972 1000 2029690 SGTC_1662 st014054 52 µM -1.51331090719537 0.196242800068461 no 2799 0.0651003517175421 1039 2838777 SGTC_466 geldanamycin 89.2 µM -1.51474799355956 0.196013876208605 no 2800 0.0649181176448738 1030 5288382 HSP90 inhibitor. SGTC_8 0354-0001 70 µM -1.51478863742668 0.196007404110105 no 2801 0.0649129694409746 1036 4993152 SGTC_2190 6049624 200 µM -1.51597341938107 0.195818797304892 no 2802 0.0647630368583492 1009 2265554 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.51797079504532 0.195501082232204 no 2803 0.0645108806106103 1034 6708561 SGTC_1441 4106-0040 13 µM -1.51801573474932 0.195493937444613 no 2804 0.064505216038435 1027 2904180 SGTC_1249 0481-0015 10.2 µM -1.51818718753751 0.195466680293723 no 2805 0.0644836082594853 1001 4227577 SGTC_937 3122-0005 46.7 µM -1.51969280118155 0.195227420611724 no 2806 0.0642941008605988 1012 759535 SGTC_2616 abietic acid 100 µM -1.52721348112208 0.194034963188224 no 2807 0.0633539675607154 1028 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_189 3970-0742 2.116 µM -1.52775252896662 0.193949664085798 no 2808 0.0632869962955057 1017 2891807 SGTC_2843 9000894 45.46 µM -1.52879456282276 0.193784837111943 no 2809 0.0631576903554328 992 2242070 SGTC_886 0866-0150 153 µM -1.53173321851017 0.19332046620595 no 2810 0.0627941407809612 1027 271463 SGTC_2102 5377816 72.7585 µM -1.53307761866946 0.193108248601712 no 2811 0.0626283657557714 1017 1379702 SGTC_425 3825-7017 13.1 µM -1.53608529654659 0.19263399289925 no 2812 0.0622587309735437 1024 3397440 SGTC_1979 st071809 45.3 µM -1.54033805859441 0.191964626303504 no 2813 0.0617389856869021 1031 4976333 SGTC_2064 5220758 200 µM -1.54092339227924 0.19187260885987 no 2814 0.061667715931013 1016 788518 SGTC_857 0438-0306 1.35 µM -1.54195844895357 0.191709958770481 no 2815 0.0615418455148799 1008 4686136 SGTC_2024 5144227 134 µM -1.54530431834208 0.191184762581129 no 2816 0.0611363357180324 1019 3475211 SGTC_845 0330-0138 4.51 µM -1.54597308490251 0.191079893154712 no 2817 0.0610555340947164 1025 9039800 SGTC_261 5-fluorouridine 15.376 µM -1.54824537700479 0.190723838171166 no 2818 0.0607816150465551 1033 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2839 9003951 25.97 µM -1.54940048508657 0.190542995644579 no 2819 0.0606427386221602 1006 2990634 SGTC_2296 7971656 126.45 µM -1.55160456245958 0.190198219780189 no 2820 0.0603784354064948 1020 666570 SGTC_1236 0330-0013 258 µM -1.5524324060407 0.190068822279557 no 2821 0.0602793972649424 1036 4617066 SGTC_1047 2043-3044 82 µM -1.55287820355809 0.189999163556955 no 2822 0.0602261174750491 1039 669592 SGTC_1742 st038235 28.8875 µM -1.55771928981096 0.189243723594431 no 2823 0.0596499028733921 1027 564103 YBR002C RER2 SGTC_1908 st060353 56.5 µM -1.55839826535266 0.189137919148584 no 2824 0.059569433792458 1023 4227716 SGTC_29 0299-0004 12.984 µM -1.56011047055275 0.188871268803515 no 2825 0.0593668888177881 1022 16871 A napthoquinone isolated from Swertia calycina. SGTC_245 methotrexate 289.6 µM -1.56022538203201 0.188853381358208 no 2826 0.0593533147448066 1018 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_68 0986-0284 82.829 µM -1.56040307460852 0.188825723285279 no 2827 0.059332329361087 998 423278 YIL048W NEO1 SGTC_230 MPP+ 141.667 µM -1.56049336067814 0.188811671101437 no 2828 0.059321668861022 1033 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2205 7238770 200 µM -1.56290574535088 0.188436444634203 no 2829 0.0590373830534548 1027 279867 SGTC_53 0973-0023 39.979 µM -1.56337576266493 0.188363390899652 no 2830 0.0589821187880698 1018 674768 SGTC_2017 5132927 60.65 µM -1.56394300269826 0.188275249324569 no 2831 0.0589154772080745 1033 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1521 st012942 49.4 µM -1.56435449690019 0.188211324513481 no 2832 0.05886717024317 1017 24207259 SGTC_2245 6637752 200 µM -1.56978173701183 0.187369467110898 no 2833 0.0582329488914218 1043 681890 SGTC_603 3794-0023 45.9 µM -1.57015888495199 0.187311051669082 no 2834 0.0581890760443291 1045 3802260 SGTC_1192 1488-0095 21.4 µM -1.57196102912826 0.187032077820536 no 2835 0.0579797947160452 1036 915875 SGTC_2606 farnesol 9.78 µM -1.57351359040425 0.186791945889026 no 2836 0.0577999719784931 1013 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2372 9071633 200 µM -1.57401186888694 0.186714918496339 no 2837 0.0577423527672645 1039 21321366 SGTC_1929 genistein trimethyl ether 50.5 µM -1.57570664133643 0.186453075857636 no 2838 0.0575467130931462 1015 136420 SGTC_2014 4013930 200 µM -1.58075501647785 0.185674449742756 no 2839 0.0569670317804966 1031 64556 SGTC_2801 7907800 81.82 µM -1.58179302650571 0.185514604717835 no 2840 0.0568484137511558 1010 6620925 SGTC_772 k072-0172 35.3 µM -1.58419263579491 0.185145411631851 no 2841 0.0565749443099552 1006 5861980 SGTC_204 PMA1.184 62.41 µM -1.58934735476021 0.184353874222725 no 2842 0.0559909965560524 1035 2252213 YGL008C PMA1 SGTC_11 0438-0307 1.3 µM -1.5913426408249 0.184048052368472 no 2843 0.0557662427013383 1032 4011476 SGTC_333 3486-0131 40.1 µM -1.59314084934737 0.183772707780046 no 2844 0.0555642985926958 1017 6744690 SGTC_2141 5621638 7.665 µM -1.59604427265948 0.183328672898808 no 2845 0.0552394545939912 1039 2856238 SGTC_1403 3909-7815 62.9 µM -1.59775652075752 0.183067124191157 no 2846 0.0550485872446051 1026 6615483 SGTC_112 phenothiazine 287.218 µM -1.59902022960384 0.182874239975485 no 2847 0.0549080538595826 1036 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1061 3448-9325 110 µM -1.59980249691097 0.182754903417928 no 2848 0.0548212023686604 1029 723482 SGTC_1370 2001-0092 44.6 µM -1.60303746601826 0.182261918329033 no 2849 0.0544631913272498 1028 790957 SGTC_2303 7774051 200 µM -1.60330940714269 0.182220514437641 no 2850 0.0544331803108885 1038 2953184 SGTC_2222 6885208 172.143 µM -1.61101315243198 0.18105003789944 no 2851 0.0535884278976482 1055 609514 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.61292193793329 0.180760754367519 no 2852 0.0533807341803083 1039 2374 Ca(2+)-ATPase inhibitor. SGTC_2855 9016525 58.44 µM -1.61394478410499 0.180605857542039 no 2853 0.0532697017508076 1024 43811474 SGTC_1482 3346-2049 8.48 µM -1.61535272876441 0.180392778724905 no 2854 0.0531171654619043 1036 3826804 SGTC_583 1488-1091 88.9 µM -1.61545744396983 0.180376937394569 no 2855 0.0531058344995869 1057 4303273 SGTC_1070 indatraline 8.81 µM -1.61632686045655 0.180245445660691 no 2856 0.0530118311819693 1036 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3012 9080433 71.4286 µM -1.6182623059559 0.179952942337247 no 2857 0.0528030402040824 1019 17688859 SGTC_1500 4488-1866 171 µM -1.61950679904314 0.179765020002387 no 2858 0.0526691323990017 1043 2900003 SGTC_1464 k208-0027 110 µM -1.62809319653157 0.178471809065965 no 2859 0.0517525629681574 1020 X1464 SGTC_133 0724-0033 378.92 µM -1.63222530212467 0.177851560097868 no 2860 0.0513160162311545 1044 280309 SGTC_932 2857-0803 154 µM -1.63307778724722 0.177723767355607 no 2861 0.0512263188348898 1041 674898 SGTC_639 0833-0042 114 µM -1.6355499395683 0.177353504276585 no 2862 0.0509669073811937 1046 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3244 9134489 49.47 µM -1.63711635555617 0.177119148824581 no 2863 0.0508030798833408 1049 16584271 SGTC_390 dec-rvkr-cmk 16.7 µM -1.63802294279051 0.176983601435112 no 2864 0.0507084539472797 1037 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1263 0774-1208 64.8 µM -1.64334241461525 0.176189587659146 no 2865 0.0501560536654259 1037 906585 SGTC_2680 butyl paraben 22.24 µM -1.64552297114223 0.175864758287042 no 2866 0.0499310047513378 1065 7184 An antifungal and steroid mimetic. SGTC_2684 capsaicin 100 µM -1.64643437194264 0.175729102777509 no 2867 0.0498371806854181 1030 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2564 betulinic acid 100 µM -1.64723167449675 0.175610484356143 no 2868 0.0497552178242636 1048 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2872 9044037 25.97 µM -1.64759244556171 0.175556827438634 no 2869 0.0497181658433456 1051 6465195 SGTC_1212 0520-0165 585 µM -1.64812763213312 0.175477249116234 no 2870 0.0496632415610514 1040 5403258 SGTC_3054 9094397 49.47 µM -1.64983251754571 0.17522389760821 no 2871 0.0494885979809095 1041 2598354 SGTC_1708 st033234 31.827 µM -1.6498661670965 0.175218899511289 no 2872 0.0494851559566452 1036 674664 SGTC_1268 0828-0275 2.46 µM -1.65179630822059 0.174932359584496 no 2873 0.0492880407727887 1044 745337 SGTC_2013 4024628 200 µM -1.65210732150142 0.174886215807216 no 2874 0.0492563373487352 1047 5230760 SGTC_3270 9137563 49.47 µM -1.65409322777105 0.174591757119772 no 2875 0.0490542859446968 1018 17015724 SGTC_1231 0242-0792 125 µM -1.65448611923317 0.174533538773508 no 2876 0.0490143906770322 1040 3707635 SGTC_46 0329-0187a 2.197 µM -1.65636269439029 0.174255639454273 no 2877 0.0488241955730498 1037 46494817 SGTC_861 0443-0273 110 µM -1.65806517916513 0.17400376432941 no 2878 0.048652155616263 1034 6149169 SGTC_1015 4130-4525 82 µM -1.66074074582474 0.173608394009304 no 2879 0.048382763131831 1040 1363237 SGTC_1794 st048918 76.9 µM -1.66640765963337 0.172772879480513 no 2880 0.0478161231130831 986 672303 SGTC_147 4466-0538 29.23 µM -1.67076877778559 0.172131636102485 no 2881 0.0473836789050431 1039 6742687 YHR072W ERG7 SGTC_31 0508-1974 57.237 µM -1.67114942187644 0.172075739707272 no 2882 0.0473460837903062 1023 6810525 SGTC_1450 4112-4260 37.6 µM -1.67132502534076 0.172049956793134 no 2883 0.0473287480037878 1032 1633175 SGTC_2789 5281112 71.43 µM -1.67184101179779 0.171974211540647 no 2884 0.0472778386277435 1031 765948 SGTC_438 sphingosine 6.67 µM -1.6745110457358 0.171582598815243 no 2885 0.047015102699696 1047 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2219 9098279 200 µM -1.67681239900149 0.171245517900857 no 2886 0.0467895861906487 1049 902349 SGTC_1318 1280-3875 124 µM -1.67901962803747 0.170922621496032 no 2887 0.0465741092415602 1043 373245 SGTC_593 1203-0218 61.7 µM -1.68165864508327 0.17053707030493 no 2888 0.0463175257833834 1053 3666956 SGTC_2581 avocatin a 64 µM -1.68223533129367 0.170452892657077 no 2889 0.0462616077490604 1053 6710728 A skin care supplement. SGTC_2603 homopterocarpin 100 µM -1.68350928527115 0.170267030668031 no 2890 0.0461382717046113 1031 101795 A weak amylase inhibitor. SGTC_3041 9091929 49.47 µM -1.68980141122868 0.169350953696614 no 2891 0.0455329768751326 1031 25236887 SGTC_1763 st044482 94.5 µM -1.68989723296542 0.169337027412759 no 2892 0.0455238085405119 1049 88505 SGTC_1822 st052468 42 µM -1.69162617499773 0.169085877343042 no 2893 0.045358636254486 1037 2873678 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.69225976003389 0.168993901256071 no 2894 0.0452982283347183 1050 140250 A respiratory chain inhibitor. SGTC_3139 9095020 49.47 µM -1.69251442004091 0.168956941902487 no 2895 0.0452739665178968 1025 25236292 SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.69431406960315 0.168695902911692 no 2896 0.0451028092115431 1037 5282309 SGTC_3018 9082602 49.47 µM -1.69665238819393 0.168357117441453 no 2897 0.0448811995388477 1015 17332089 SGTC_1762 st045503 25.4615 µM -1.69776954954073 0.168195412963904 no 2898 0.0447756325978679 1055 4645554 SGTC_1829 berberine 14.4 µM -1.69871932813545 0.168058015059559 no 2899 0.044686039942092 983 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1850 st056238 17 µM -1.69892086967355 0.168028868730559 no 2900 0.0446670471012515 1026 5393177 SGTC_271 rotenone 740 µM -1.69931481779976 0.16797190653616 no 2901 0.044629941052449 1052 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_3176 9106582 49.47 µM -1.70073762191215 0.167766282349629 no 2902 0.0444961335815373 1050 17018027 SGTC_807 1315-0151 48 µM -1.70123182573167 0.167694897770021 no 2903 0.0444497319327438 1048 4011080 SGTC_486 niguldipine 82 µM -1.70180998667228 0.167611410953051 no 2904 0.044395496899474 1041 1236 A calcium channel blocker. SGTC_251 melphalan 456.522 µM -1.70384238347721 0.167318144036075 no 2905 0.0442052687091764 1061 460612 A DNA alkylator. SGTC_3248 9135562 49.47 µM -1.70571131958512 0.167048755915404 no 2906 0.0440309205335567 1051 17650701 SGTC_187 1488-2104 32.728 µM -1.70590612163815 0.167020693285795 no 2907 0.0440127799120731 1047 2852859 SGTC_560 2332-1943 155 µM -1.70595212603165 0.167014066467511 no 2908 0.0440084967082691 1043 21177716 SGTC_1950 st077106 7.18 µM -1.70818379512888 0.166692803718375 no 2909 0.0438011221928946 1023 13831864 SGTC_2541 muurolladie-3-one 83.07 µM -1.71038314195264 0.1663765843831 no 2910 0.0435975231541937 1012 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3117 9124945 49.47 µM -1.71569184136265 0.165614903212838 no 2911 0.0431092294066144 1028 17592065 SGTC_2345 9052315 157.45 µM -1.72050230589373 0.164926658403561 no 2912 0.0426705874436972 1034 6469265 SGTC_1611 st001856 99.4 µM -1.72308713547783 0.164557606692364 no 2913 0.0424363844242976 1048 647478 SGTC_684 1140-0066 328 µM -1.72979923948973 0.163601780408314 no 2914 0.0418330751913701 1051 6813534 SGTC_1238 0333-0287 48.8 µM -1.73548621118767 0.162794763204151 no 2915 0.0413273608695214 1042 7226 SGTC_1158 4092-0494 91.8 µM -1.73625442580461 0.162685947515664 no 2916 0.0412594288305703 1053 1148199 SGTC_2482 5981709 142.65 µM -1.73630089231376 0.16267936716808 no 2917 0.0412553227734406 1037 877755 SGTC_726 3448-4391 34.2 µM -1.73762514862492 0.162491905593002 no 2918 0.0411384427867949 1049 1356692 SGTC_318 1488-0629 67.2 µM -1.73921481828562 0.162267057864077 no 2919 0.0409984919530575 1053 3662576 SGTC_1042 0350-0096 82 µM -1.7406794777006 0.162060071340408 no 2920 0.0408698887623892 1046 3122515 SGTC_1748 st037455 53.6035 µM -1.74256083534865 0.161794449196802 no 2921 0.0407051781070939 1052 580690 SGTC_1045 1348-1485 165 µM -1.74844170548654 0.160965980711535 no 2922 0.0401937857660446 1048 6810614 SGTC_636 0kpi-0074 126 µM -1.74971808913889 0.160786536308537 no 2923 0.040083485377409 1045 616434 SGTC_2750 bromebric acid 70.15 µM -1.75456530413979 0.160106265720028 no 2924 0.0396668452592801 1047 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_671 0560-0003 407 µM -1.76288393383482 0.158943200184348 no 2925 0.038960033640212 1055 3238678 SGTC_3222 9128301 49.47 µM -1.76303413097951 0.158922251450471 no 2926 0.0389473666688849 1011 4911358 SGTC_1976 st070609 63.5 µM -1.76434358308968 0.158739692385003 no 2927 0.0388370752067326 1044 682556 SGTC_1980 st071811 45.7 µM -1.76696947525473 0.1583740144624 no 2928 0.0386166702481016 1053 4974850 SGTC_1436 4092-1007 8.32 µM -1.7673160225967 0.158325796096077 no 2929 0.0385876589841057 1046 2881121 SGTC_2463 5473429 200 µM -1.76823429018847 0.158198075535055 no 2930 0.038510871943629 1052 5399405 SGTC_676 falcarinol 140 µM -1.76879890204351 0.158119578036445 no 2931 0.0384637200329093 1036 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1225 1216-0074 20.6 µM -1.76967778309095 0.157997438843406 no 2932 0.0383904164901294 1053 4241466 SGTC_79 0052-0007 94.094 µM -1.77128259921071 0.157774575404336 no 2933 0.0382568597904857 1025 2801472 SGTC_1194 1488-0194 225 µM -1.7736890778557 0.157440770916392 no 2934 0.0380572970302515 1057 1391452 SGTC_2778 tioconazole 65.09 nM -1.77587961410093 0.157137323813244 no 2935 0.0378763808533534 1019 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1494 4358-1428 177 µM -1.7775295447892 0.156909018971705 no 2936 0.0377405771223478 1042 1564571 SGTC_2779 methotrexate 400 µM -1.77909118868669 0.156693131716125 no 2937 0.037612406529636 1020 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.78405401409726 0.156008351433583 no 2938 0.0372074443303825 1045 676296 Flavone; oxidizing agent. SGTC_890 0929-0006 47.2 µM -1.78446558890253 0.155951650246201 no 2939 0.0371740207799936 1054 1378169 SGTC_1709 st033179 39.1045 µM -1.78549166060564 0.155810351174495 no 2940 0.0370908014105414 1046 573381 SGTC_1847 st056231 15 µM -1.78841703889009 0.155407964461312 no 2941 0.0368543746677949 1036 5393180 SGTC_1629 st005085 44.9 µM -1.78927501371121 0.155290079913038 no 2942 0.036785267999072 1029 24207091 SGTC_2086 5274770 176.623 µM -1.79212084592396 0.154899489163201 no 2943 0.0365568051765168 1046 689278 SGTC_3195 9113082 49.47 µM -1.79833207108626 0.154049253458302 no 2944 0.0360622001759516 1062 17018038 SGTC_595 3909-8003 73.7 µM -1.79929439521218 0.153917800606453 no 2945 0.0359860621097774 1064 699517 SGTC_75 0159-0059 199.013 µM -1.79938470222553 0.153905468537941 no 2946 0.0359789238773511 1054 5377270 SGTC_2674 ligustilide 100 µM -1.79991549971943 0.15383299756092 no 2947 0.0359369909308256 1054 5319022 A signalling regulator. SGTC_2085 5307070 144.047 µM -1.8005318144326 0.153748879067873 no 2948 0.0358883523711358 1052 2840351 SGTC_3128 9127691 49.47 µM -1.80087491994159 0.153702063075137 no 2949 0.0358612984169357 1042 41316314 SGTC_1179 1021-1431 9.29 µM -1.80120551606358 0.15365696288941 no 2950 0.0358352466394716 1055 2840958 SGTC_723 4182-0001 115 µM -1.80796194300051 0.152737165195588 no 2951 0.0353062119474779 1043 744821 YLR208W SEC13 SGTC_1910 st062352 60.4 µM -1.81240366565472 0.152134477352989 no 2952 0.0349619234328408 1048 2245730 SGTC_2362 9071156 126 µM -1.81537986155011 0.151731528475703 no 2953 0.0347327768574828 1060 653133 SGTC_3114 9122766 49.47 µM -1.81610186105378 0.151633883545722 no 2954 0.0346773741463238 1034 17176985 SGTC_2518 prenyletin 46.28 µM -1.82062369163933 0.151023290536808 no 2955 0.0343320394689272 1051 3873459 A coumarin with calcium channel inhibitory activity. SGTC_13 0199-0087 65 µM -1.82079793397347 0.150999794985325 no 2956 0.034318789243138 1066 4589825 SGTC_1649 st011737 51.3 µM -1.8285653522246 0.149954875621738 no 2957 0.0337323735628516 1023 1761035 SGTC_1472 k841-0093 193 µM -1.83049199201542 0.149696440678406 no 2958 0.0335882015713546 1060 X1472 SGTC_1033 k072-0102 21.3 µM -1.83054939944342 0.149688744742325 no 2959 0.0335839135210248 1034 5965931 SGTC_1985 st071382 65.5 µM -1.83361787208975 0.149277774964338 no 2960 0.0333553686931129 1064 6123237 SGTC_1905 st060207 84.5 µM -1.84121252299047 0.148263843130482 no 2961 0.0327952104489168 1039 1948547 SGTC_479 n-linoleoylglycine 10 µM -1.84169369106642 0.148199759846947 no 2962 0.0327599837827811 1066 6433346 An anti-infammatory. SGTC_364 0083-0097 67.7 µM -1.84175535064857 0.148191549194531 no 2963 0.0327554718956097 1062 5207356 SGTC_1159 4092-0538 61.2 µM -1.84184697095051 0.14817934950446 no 2964 0.0327487686046509 1055 717301 SGTC_2645 abamectin 100 µM -1.85423505531914 0.146536002669082 no 2965 0.031852769450375 981 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_622 1348-1566 26.3 µM -1.85434871343606 0.14652098215311 no 2966 0.0318446435442913 1060 7340407 SGTC_2933 9026794 32.47 µM -1.85651787409719 0.146234514270556 no 2967 0.0316898888614992 1038 17586027 SGTC_1786 berberine 21.6 µM -1.85996210049443 0.14578042945148 no 2968 0.0314454441011874 1007 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2741 miltefosine 3.04 µM -1.86325810477876 0.14534677451474 no 2969 0.031212980725983 1053 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_901 1112-0062 60.1 µM -1.86460906272768 0.145169280115709 no 2970 0.0311181108084432 1052 1908457 SGTC_998 3996-0085 177 µM -1.87204356836848 0.14419511497491 no 2971 0.0306002880814044 1063 715391 SGTC_2404 5161160 200 µM -1.87628123229162 0.143641817898139 no 2972 0.0303083363660558 1041 2831543 SGTC_556 4058-0063 51.5 µM -1.87647557767662 0.143616477304525 no 2973 0.0302950025892857 1065 6615692 SGTC_732 3970-1727 52.7 µM -1.87958381858773 0.143211605394344 no 2974 0.0300824101436158 1065 1275699 SGTC_1294 1000-1494 117 µM -1.88068032658139 0.143068961057245 no 2975 0.0300077087202346 1066 712797 YDL207W GLE1 SGTC_1824 st053723 68.6 µM -1.88285087543105 0.142786878284911 no 2976 0.0298602900821017 1050 675225 SGTC_1180 1193-0155 285 µM -1.88315927259262 0.142746829763504 no 2977 0.0298393932857958 1068 2921347 SGTC_2683 piperine 63.03 µM -1.8888194567165 0.142013145627092 no 2978 0.0294580123757213 1069 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_89 0302-0250 142.109 µM -1.88890155625684 0.142002522540399 no 2979 0.0294525104570613 1074 4203518 YLR208W SEC13 SGTC_1104 tacrolimus 29.8 µM -1.8913318697396 0.141688301205538 no 2980 0.0292900284875457 1046 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1010 4112-3296 15.2 µM -1.89148375001511 0.141668679871782 no 2981 0.0292798990857173 1041 704384 SGTC_1149 3909-7961 23.3 µM -1.891920409087 0.141612278366904 no 2982 0.0292507930419223 1061 735261 SGTC_657 3534-0529 86.7 µM -1.89476441485718 0.141245301743954 no 2983 0.0290618097869277 1073 1049549 SGTC_3141 9094609 49.47 µM -1.90327034154939 0.140151588662999 no 2984 0.0285026393740992 1046 25236309 YDL196W YDL196W SGTC_2699 st077704 54.6 µM -1.90402192582804 0.140055225487163 no 2985 0.0284536643440431 1061 645852 SGTC_2860 9025725 38.96 µM -1.90776600608363 0.139575855023369 no 2986 0.0282107331204518 1069 40546248 SGTC_1955 wogonin 32.4 µM -1.90986180580488 0.139308008564616 no 2987 0.028075504453489 1043 5281703 A flavanone. SGTC_2061 5245884 80.95 µM -1.91146699026171 0.139103100149904 no 2988 0.0279722974735587 1068 573863 SGTC_2486 5283202 22.39 µM -1.91226317740711 0.139001539729774 no 2989 0.0279212231573292 1051 1377751 SGTC_1951 sophoraflavanone G 9.2 µM -1.91686428062348 0.138415618900682 no 2990 0.0276275879912072 1047 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2297 7971671 152.32 µM -1.91688436195483 0.138413065367336 no 2991 0.0276263120954585 1046 909016 SGTC_618 k072-0232 33.2 µM -1.91699367294222 0.138399165992849 no 2992 0.0276193677287525 1032 5872756 YGL099W LSG1 SGTC_464 bw-b 70c 158 µM -1.9171574381846 0.138378344299722 no 2993 0.027608966685849 1065 5353454 SGTC_2125 5246583 200 µM -1.91995952710835 0.138022407578493 no 2994 0.0274315059318222 1066 835267 SGTC_405 ebelactone b 50 µM -1.92050945202754 0.137952626459643 no 2995 0.0273967901978934 1058 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_920 mycophenolic acid 780.421 nM -1.92263657834888 0.137682937561015 no 2996 0.0272628534375357 1066 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2220 6782180 200 µM -1.92321582380622 0.137609559975502 no 2997 0.0272264753996382 1056 833803 SGTC_2557 derrustone 83.84 µM -1.92335331503429 0.13759214679896 no 2998 0.0272178465618867 1052 629853 An antioxidant. SGTC_2089 5281248 129.67 µM -1.92400125716527 0.137510105586105 no 2999 0.0271772129439565 1049 2737878 SGTC_779 1360-0071 233 µM -1.92705500824182 0.137123895013956 no 3000 0.0269863874818955 1052 7566 SGTC_2739 tacrine 100.86 µM -1.92923905567034 0.136848131564549 no 3001 0.0268505958528389 979 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_266 formosanin C 406 nM -1.92937631882658 0.136830813034426 no 3002 0.0268420806994772 1035 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1883 5-benzylidenerhodanine 20 µM -1.93981334852531 0.135518356420942 no 3003 0.0262011889025042 1045 1273210 SGTC_1958 st076513 41.9 µM -1.94831617965862 0.134455521311571 no 3004 0.025688571174674 1064 732122 YGL099W LSG1 SGTC_1912 st060209 90.8 µM -1.95031818220675 0.134206110024842 no 3005 0.0255691034281837 1060 688787 SGTC_85 0868-0259 160.055 µM -1.9517512573108 0.13402777150335 no 3006 0.0254838719093385 1044 83173 SGTC_737 1950-0117 57.9 µM -1.95601892496257 0.133497647884434 no 3007 0.0252314623837583 1050 5393513 SGTC_1326 1431-2094 10.8 µM -1.9566973719576 0.133413505197569 no 3008 0.0251915295345375 1051 616278 SGTC_1476 4112-3294 3.34 µM -1.96408222128109 0.132499977322183 no 3009 0.0247602788129181 1016 704369 SGTC_406 estrone 100 µM -1.96602187135057 0.132260753206487 no 3010 0.0246480421164939 1058 5870 A steroid. SGTC_3179 9107801 49.47 µM -1.96793749330125 0.132024784951876 no 3011 0.0245376150802433 1056 4818259 SGTC_1745 st081495 74 µM -1.97000423044246 0.131770527942462 no 3012 0.0244189428608507 1045 13842402 YBL026W LSM2 SGTC_1663 st014140 55.4 µM -1.97374517859267 0.131311163472589 no 3013 0.0242053626194058 1055 4207120 SGTC_1680 diphenhydramine 100 µM -1.98477016227572 0.129963802716249 no 3014 0.0235850243036836 1041 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1726 st035556 14.5795 µM -1.9893134054826 0.129411368135597 no 3015 0.0233333104664341 1048 5919439 SGTC_3097 9117246 49.47 µM -1.99553238666531 0.128657813959807 no 3016 0.022992422755563 1065 16423892 SGTC_3016 9080866 49.47 µM -1.9960086359754 0.128600232583625 no 3017 0.0229664913966314 1069 17066299 SGTC_2502 avocadyne acetate 18.59 µM -1.99731924856336 0.128441864058239 no 3018 0.0228952568317336 1050 3952079 SGTC_1334 1486-0610 236 µM -1.99779795292409 0.128384053347196 no 3019 0.0228692846892797 1051 3742339 SGTC_584 0986-0246 15.4 µM -1.99863072547315 0.128283526659214 no 3020 0.0228241617009766 1071 53315 YDR232W HEM1 SGTC_2716 st080858 38.6235 µM -2.00024847959774 0.128088398536959 no 3021 0.0227367196276405 1049 5296050 SGTC_1900 st060200 72.8 µM -2.00087065789292 0.128013408380344 no 3022 0.0227031651968149 1053 688945 SGTC_456 gingerol 170 µM -2.00883079820986 0.127056676222999 no 3023 0.0222775404321122 1063 442793 A herb. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -2.01178739640734 0.126702592181538 no 3024 0.0221211765497924 1057 688664 SGTC_250 brefeldin a 552.239 µM -2.01251312002763 0.126615784204703 no 3025 0.0220829375299191 1081 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_918 glabranin 770.725 nM -2.01490674746822 0.126329762316868 no 3026 0.021957210440694 1074 124049 Also referred to as licorice root. SGTC_280 3448-3607 3.04 µM -2.01752401766641 0.126017532323715 no 3027 0.0218204286001661 1037 626179 SGTC_2032 5185112 25.99 µM -2.0177334909129 0.125992566268193 no 3028 0.0218095124363814 1060 5718189 SGTC_1344 1488-0097 29.1 µM -2.01917456898875 0.125820904944826 no 3029 0.021734539277078 1074 747966 SGTC_198 3454-2873 16.191 µM -2.02020686811609 0.125698037725261 no 3030 0.0216809670886753 1065 710957 SGTC_476 mead acid 10 µM -2.02161056457103 0.125531100056602 no 3031 0.0216082998924848 1074 5312531 An omega 9 fatty acid. SGTC_702 1488-0190 94 µM -2.02234797673785 0.12544346371938 no 3032 0.0215702077343933 1072 949357 SGTC_819 1013-0258 27.7 µM -2.02252543120517 0.12542238085894 no 3033 0.0215610495274229 1063 5753198 SGTC_522 1273-0010 11.6 µM -2.02349919295787 0.125306735017228 no 3034 0.0215108533514375 1056 5705015 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -2.02656873757642 0.124942677194888 no 3035 0.0213532682087441 1066 551469 SGTC_2646 retinol 96.75 µM -2.02671789260653 0.124925005775035 no 3036 0.0213456357797539 1061 445354 A vitamin A analog and teratogen. SGTC_872 0588-0139 234 µM -2.02858737701399 0.124703663219592 no 3037 0.0212501676692731 1068 2047100 SGTC_1602 st001878 87.6 µM -2.03196978597274 0.124303890838706 no 3038 0.0210783573900731 1061 595405 YLR310C CDC25 SGTC_2927 9011802 47.9 µM -2.03320598403191 0.124158006496474 no 3039 0.0210158583762188 1059 43912568 SGTC_786 4544-0069 423 µM -2.0380725428305 0.123584865575575 no 3040 0.0207713393022925 1060 748821 YLR208W SEC13 SGTC_1887 st057648 70.8 µM -2.04037593162804 0.123314239514733 no 3041 0.0206564486153535 1061 688672 SGTC_1404 3909-7820 48.3 µM -2.04183941269908 0.123142510412757 no 3042 0.0205837316544915 1027 23741373 SGTC_865 0488-0499 301 µM -2.0438049740294 0.122912129599466 no 3043 0.020486408798047 1063 9634651 SGTC_2135 5326629 150.42 µM -2.05173001205005 0.121986312831401 no 3044 0.0200979541732745 1064 5020077 SGTC_3188 9110789 49.47 µM -2.05482525131487 0.121626054960685 no 3045 0.0199479431585049 1056 849217 SGTC_3339 9145883 14.936 µM -2.05652720502049 0.121428281850724 no 3046 0.0198658633878399 1034 2030670 SGTC_2331 7980721 200 µM -2.05934874735682 0.121100906852792 no 3047 0.0197304208974312 1047 2981221 SGTC_1717 st033143 58.0435 µM -2.06049389830331 0.120968215753963 no 3048 0.0196756742871459 1060 674616 SGTC_943 3253-1379 105 µM -2.06074128289046 0.120939564212754 no 3049 0.0196638644456797 1053 668464 SGTC_847 0342-0274 5.54 µM -2.06408184602794 0.120553135053982 no 3050 0.019504978451899 1065 18097 SGTC_866 0495-0101 262 µM -2.0673827190731 0.120172151969965 no 3051 0.0193490526461235 1043 635694 SGTC_3137 9097352 49.47 µM -2.06870077850001 0.120020260291596 no 3052 0.0192870870599402 1049 44120435 SGTC_569 4130-2812 160 µM -2.07480373926248 0.11931872592201 no 3053 0.0190023639487982 1071 743552 SGTC_2844 9010103 25.97 µM -2.07743588614661 0.11901705597022 no 3054 0.0188806734675602 1054 2480525 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -2.07831732025913 0.118916155411279 no 3055 0.018840071105675 1063 688667 SGTC_3343 9148379 18.9835 µM -2.0784464053535 0.118901383703968 no 3056 0.0188341311734791 1040 1955036 SGTC_1653 st012112 65 µM -2.07953999522691 0.118776291972139 no 3057 0.0187838728439779 1067 720429 SGTC_411 enrofloxacin 100 µM -2.08114754691775 0.118592578850064 no 3058 0.0187102014683144 1058 71188 A bacterial gyrase inhibitor. SGTC_1716 st033144 30.6155 µM -2.0816659007931 0.118533383520489 no 3059 0.0186864986799173 1071 674617 SGTC_1697 st025554 27.742 µM -2.08508020798929 0.118143995865389 no 3060 0.0185310102492377 1072 1269519 SGTC_953 1188-0045 9.7 µM -2.09501834193476 0.117015744092328 no 3061 0.0180846810063318 1049 6144426 SGTC_1306 1185-0270 9.02 µM -2.10145828063282 0.116288722951512 no 3062 0.0178003782706189 1069 1548076 SGTC_135 0933-0004 26.348 µM -2.10392983924583 0.116010555209684 no 3063 0.0176922838153431 1045 21230617 YGL099W LSG1 SGTC_3281 9140613 49.47 µM -2.1042348995179 0.115976254215786 no 3064 0.0176789808157656 1048 16013766 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -2.10473699780919 0.115919813935003 no 3065 0.0176571040128321 1062 7104 SGTC_118 0083-0097 135.343 µM -2.10656666031785 0.115714308738602 no 3066 0.0175775796090422 1073 5207356 SGTC_1561 5-methoxyflavone 52.9 µM -2.10764715497844 0.115593070650557 no 3067 0.0175307607492705 1055 94525 SGTC_126 0417-1624 672.48 µM -2.10861482984393 0.115484568255447 no 3068 0.0174889208836213 1063 41912 YDL195W SEC31 SGTC_1766 st045414 44.774 µM -2.1089676341398 0.115445027406884 no 3069 0.0174736877217239 1055 253960 SGTC_2416 tofa 880 nM -2.10964259929195 0.115369406911007 no 3070 0.0174445760682317 1051 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2254 7938975 95.19 µM -2.11192150095876 0.115114347653743 no 3071 0.0173465914348892 1067 2969277 SGTC_1354 1498-1681 81 µM -2.11541733538824 0.114723866526807 no 3072 0.0171971967936505 1078 5754243 SGTC_1989 st071868 50.2 µM -2.11722310023228 0.114522533994665 no 3073 0.0171204588855695 1071 16414057 SGTC_764 1951-2361 146 µM -2.12020386985145 0.114190745527902 no 3074 0.0169944281071615 1054 5438930 SGTC_1001 4048-4355 44.4 µM -2.12382148651443 0.113788990175696 no 3075 0.0168425367998836 1063 21824233 SGTC_2883 9059145 45.46 µM -2.13265477006472 0.112812243318434 no 3076 0.0164765284074311 1078 16476510 SGTC_2382 9035899 200 µM -2.13632469177382 0.112408204114737 no 3077 0.0163264788136248 1073 6462679 SGTC_1152 3909-8331 15.9 µM -2.13710639010105 0.112322276941139 no 3078 0.0162946696694394 1062 16001939 SGTC_1193 1488-0126 41.5 µM -2.13721889221964 0.112309914156496 no 3079 0.0162900960657638 1068 1384710 SGTC_609 0986-0026 86.3 µM -2.14004039716005 0.112000178747219 no 3080 0.0161757510922996 1055 2848610 SGTC_376 3970-0862 59.1 µM -2.1446580761849 0.111494583881116 no 3081 0.015990097596151 1068 3135186 SGTC_668 1682-0499 62.6 µM -2.15043152286609 0.110864743140429 no 3082 0.015760548558915 1077 682214 SGTC_696 1560-0013 611 µM -2.15392909912826 0.110484425247994 no 3083 0.0156228662690514 1072 1650269 SGTC_2722 naftopidil 47.16 µM -2.15842915265567 0.109996477513714 no 3084 0.0154472405902751 1065 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3329 9141233 27.5565 µM -2.16123816875906 0.109692676499659 no 3085 0.0153384732062146 1051 4909101 YNL103W MET4 SGTC_2164 5685496 200 µM -2.16426772242594 0.109365699566782 no 3086 0.0152219042141459 1069 759046 SGTC_1770 st043884 66.3 µM -2.16472529610398 0.109316374983103 no 3087 0.0152043643393927 1074 670149 SGTC_3213 9129884 49.47 µM -2.16490333816933 0.109297187091195 no 3088 0.015197544262118 1063 17190742 SGTC_947 3447-0010 211 µM -2.16503671145915 0.109282814813364 no 3089 0.0151924369883506 1077 748350 SGTC_1369 1866-0067 208 µM -2.16533977074997 0.109250162255428 no 3090 0.015180837396794 1057 3531355 SGTC_3058 9093861 49.47 µM -2.16690727524394 0.109081386294142 no 3091 0.0151209625542603 1059 17217477 SGTC_1557 sumaresinolic acid 42.3 µM -2.16763417523413 0.109003183323984 no 3092 0.0150932656886217 1068 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3032 9089427 49.47 µM -2.17195613663825 0.108539040513297 no 3093 0.0149294857891032 1031 17173707 SGTC_2333 9017922 200 µM -2.17402535015128 0.108317328117247 no 3094 0.0148516157233479 1061 3163164 SGTC_568 1193-0097 7.48 µM -2.18457678190629 0.107191829467554 no 3095 0.0144599459255582 1017 3646150 SGTC_2824 7998404 51.95 µM -2.18803386447498 0.106824910399352 no 3096 0.0143335678277165 1073 837851 SGTC_33 0986-0033 35.816 µM -2.18832900674304 0.106793627375372 no 3097 0.0143228227260943 1070 2848082 SGTC_2540 epiandrosterone 100 µM -2.19490565260977 0.106098262764002 no 3098 0.0140851831336255 1065 441302 A steroid. SGTC_2968 9090663 33.37 µM -2.1967594589073 0.105902847650778 no 3099 0.014018814937343 1046 25236811 SGTC_2010 4012422 159 µM -2.2053017792655 0.105005737564844 no 3100 0.0137164625394875 1065 952393 SGTC_904 1141-0088 396 µM -2.20952306987846 0.104564456165293 no 3101 0.0135691397938282 1082 1378119 SGTC_2572 astragaloside iv 100 µM -2.20973316284221 0.104542528807642 no 3102 0.0135618433769802 1063 45006101 An anti-inflammatory agent. SGTC_2434 5670830 169.91 µM -2.21081976097851 0.104429173959337 no 3103 0.0135241604262139 1070 1549830 SGTC_1673 st016611 27.3 µM -2.21656883156326 0.103830907965772 no 3104 0.0133262847168848 1076 5226799 SGTC_3047 9092122 49.47 µM -2.22645267305925 0.102808183042385 no 3105 0.0129919378413757 1068 17173831 SGTC_2327 6189656 200 µM -2.22659175628185 0.10279384390049 no 3106 0.0129872852080709 1070 5349088 SGTC_989 1501-0895 10.3 µM -2.22660679484396 0.102792293548391 no 3107 0.0129867822220951 1068 2830112 SGTC_1321 1326-2144 215 µM -2.22914375422733 0.102530997053013 no 3108 0.0129021707416554 1073 3513030 SGTC_936 3005-4620 401 µM -2.23149673457703 0.102289081585373 no 3109 0.0128241217892439 1070 777207 SGTC_2243 6634756 200 µM -2.2325617669448 0.102179719674802 no 3110 0.0127889288723829 1065 885676 SGTC_1004 4084-0029 199 µM -2.23753711094701 0.101669957562658 no 3111 0.0126256283197918 1075 716894 YLR208W SEC13 SGTC_214 4373-3496 70 µM -2.23837236001744 0.101584561732998 no 3112 0.012598391469335 1078 3779166 SGTC_191 3914-0123 66.505 µM -2.24455776616126 0.100953791263417 no 3113 0.0123982683015503 1082 3144412 SGTC_2218 6965428 192.983 µM -2.24910302585789 0.100492101711591 no 3114 0.0122529710461382 1070 675684 SGTC_2681 menadione 3.18 µM -2.25025087690218 0.100375751554232 no 3115 0.0122165121565541 1073 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1560 lithocholic acid 53.1 µM -2.25463920531022 0.0999318417239417 no 3116 0.0120779922472698 1062 9903 A bile acid which acts as a detergent. SGTC_1814 st052110 31.539 µM -2.25566523475264 0.0998282588511181 no 3117 0.0120458021907898 1078 674163 SGTC_1257 0669-0121 16 µM -2.26451635672248 0.098937948128034 no 3118 0.0117711874480175 1067 4307855 SGTC_2215 7188065 200 µM -2.2687013769564 0.0985190165470268 no 3119 0.0116432459098687 1077 940217 SGTC_23 0213-0011 39.996 µM -2.2690149451485 0.0984876799211002 no 3120 0.0116337085217927 1074 627608 SGTC_2524 avocatin b 10.57 µM -2.27897815883293 0.0974957966266663 no 3121 0.0113341818353771 1084 6710748 SGTC_2939 9044578 71.43 µM -2.27990105196747 0.0974042905133261 no 3122 0.0113067788323861 1077 2653634 SGTC_2675 theaflavin digallate 100 µM -2.28369619859517 0.0970286587436754 no 3123 0.0111946958137769 1083 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -2.29091155095706 0.0963174401933216 no 3124 0.0109842648900375 1081 688664 SGTC_2045 5106652 78.05 µM -2.29094852592766 0.0963138054578617 no 3125 0.0109831954636052 1073 673349 SGTC_539 4859-0462 2.54 µM -2.29594947805381 0.0958231273110075 no 3126 0.0108393851244818 1059 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2506 ethyl hematommate 54.16 µM -2.30268380399875 0.0951652844889272 no 3127 0.0106483200525223 1080 3940691 An allergen. SGTC_100 0086-0128 49.5915 µM -2.30325394280672 0.095109743543721 no 3128 0.0106322796842292 1076 93297 SGTC_2517 totarol 10 µM -2.30606586475936 0.0948361650611187 no 3129 0.0105534761577129 1072 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2744 captopril 92.04 µM -2.30649848334061 0.0947941261044955 no 3130 0.0105413973893282 1079 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_810 3825-7150 143 µM -2.31373655913009 0.0940928143117851 no 3131 0.0103410885990252 1045 22330411 YGL099W LSG1 SGTC_129 0088-0017 176.636 µM -2.31808185393998 0.0936736329596892 no 3132 0.0102224364542783 1080 182446 SGTC_431 k089-0097 107 µM -2.31862953698135 0.0936208971400233 no 3133 0.0102075660687893 1033 5499420 SGTC_167 3672-0051 66.205 µM -2.32125312879343 0.0933685782819538 no 3134 0.0101365931479176 1073 3237971 SGTC_1360 1598-0022 39.8 µM -2.32596829232189 0.0929163698993735 no 3135 0.0100101211337291 1081 761525 SGTC_2238 6671620 73.2395 µM -2.32660555967203 0.0928553771113443 no 3136 0.00999313418410839 1064 729941 SGTC_40 0327-0103 19.753 µM -2.34226832851745 0.0913655866471375 no 3137 0.00958346466264055 1057 409036 SGTC_1130 3454-2858 15.9 µM -2.34611172726045 0.0910027377094089 no 3138 0.00948520995804099 1070 715628 YIL048W NEO1 SGTC_763 3453-1109 128 µM -2.35011437687487 0.0906259915737071 no 3139 0.00938382154126657 1083 1560353 SGTC_2807 7945238 51.95 µM -2.35399875668004 0.090261485593216 no 3140 0.00928633660354323 1079 17148797 SGTC_2823 7987624 58.44 µM -2.35433251247195 0.0902302171857839 no 3141 0.00927800194012223 1063 2239440 SGTC_1405 3909-7894 12 µM -2.35631959878841 0.0900442205828743 no 3142 0.00922851511460415 1047 7104060 SGTC_3129 9127257 49.47 µM -2.36233462486911 0.0894829344855452 no 3143 0.00908012093561885 1076 837894 SGTC_1664 st014217 9.02 µM -2.36571582360759 0.089168566000655 no 3144 0.00899762561234545 1061 3982782 SGTC_211 3455-0679 143.504 µM -2.36578673755103 0.0891619815550884 no 3145 0.00899590248823836 1072 748649 SGTC_2942 9052777 62.25 µM -2.37040679185609 0.0887337831811756 no 3146 0.00888426173454466 1079 6469503 SGTC_2250 alverine citrate 130 µM -2.37822819387222 0.0880123695760383 no 3147 0.00869802835572259 1054 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2059 5238311 157 µM -2.38478104117031 0.0874113365445333 no 3148 0.00854464465352494 1072 703021 SGTC_1043 0916-0009 19.3 µM -2.3862407491377 0.087277869036626 no 3149 0.00851080198326048 1083 3101130 SGTC_3262 9137218 49.47 µM -2.38765571642477 0.0871486376476537 no 3150 0.00847810893000019 1073 17650664 SGTC_2670 beta-carotene 100 µM -2.39092449871862 0.0868506405892523 no 3151 0.00840300425843721 1084 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_505 gw-5074 63.9 µM -2.39672081264251 0.0863240952501575 no 3152 0.00827126138432987 1071 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_404 fumagillin 50 µM -2.40172603251268 0.0858713379202685 no 3153 0.00815896220692364 1075 12015870 A methionine aminopeptidase binder. SGTC_2854 9024559 71.43 µM -2.40930048885875 0.0851895582827762 no 3154 0.00799156612646385 1061 3163529 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -2.41210371236234 0.0849382700620966 no 3155 0.00793038455535563 1080 688751 SGTC_3098 9119039 49.47 µM -2.41546683537663 0.0846375247072636 no 3156 0.00785752677278776 1079 17161528 SGTC_490 phenamil 164 µM -2.42143128747202 0.0841061223321486 no 3157 0.00772976170112677 1010 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2995 9067767 71.4286 µM -2.42466366917028 0.083819182077276 no 3158 0.00766128739658571 1075 11673567 SGTC_2913 7966556 36.57 µM -2.4265065436228 0.0836559185623306 no 3159 0.00762248769956911 1045 2976516 SGTC_3116 9124943 49.47 µM -2.4282138843155 0.083504875539443 no 3160 0.00758669601666409 1077 41905195 YPL160W CDC60 SGTC_412 gemfibrozil 100 µM -2.4447275059617 0.082054530025167 no 3161 0.0072480810384379 1079 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_339 3091-4833 71.4 µM -2.46012513690116 0.0807193728077589 no 3162 0.00694442897692292 1063 3240077 SGTC_2175 5807670 165.306 µM -2.46467948936768 0.0803276174526666 no 3163 0.00685679297382541 1080 241186 SGTC_2570 licareol 100 µM -2.46746927917733 0.080088356489161 no 3164 0.00680359484542815 1068 443158 SGTC_49 0717-0965 32.132 µM -2.46773140251204 0.0800659037024804 no 3165 0.00679861523880568 1081 5889349 YGL099W LSG1 SGTC_2964 9083345 53.42 µM -2.47051755651873 0.079827543206612 no 3166 0.00674588480928475 1066 17741579 SGTC_1667 st014849 34.6 µM -2.48585504516651 0.0785249934298052 no 3167 0.00646202981118496 1086 5348460 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -2.48670039790685 0.0784536723563456 no 3168 0.00644669650785283 1070 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1143 3454-2408 5.08 µM -2.48863114879113 0.0782909621454753 no 3169 0.00641179653545917 1061 X1143 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.49054692704862 0.0781297667890341 no 3170 0.00637733255642336 1078 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_207 4185-0010 4.486 µM -2.49756754828244 0.077541196573032 no 3171 0.00625243193114368 1077 3761753 SGTC_562 3772-2733 112 µM -2.49959982346397 0.0773714517417979 no 3172 0.0062166832500883 1080 2876874 YIL048W NEO1 SGTC_864 0469-0573 172 µM -2.50011668586173 0.0773283261046046 no 3173 0.00620762031922675 1087 689425 SGTC_3089 9117425 49.47 µM -2.50531907842284 0.0768952684754353 no 3174 0.00611704851885551 1084 9401657 SGTC_1407 3909-7909 12.3 µM -2.50671525693033 0.0767793621375452 no 3175 0.00609294169328365 1071 4411780 SGTC_564 3555-0129 330 µM -2.51156588103219 0.0763777109397642 no 3176 0.00600984240663801 1077 563260 SGTC_3287 9117173 37.0625 µM -2.51157015440749 0.0763773577932966 no 3177 0.0060097696417322 1057 2789709 SGTC_2918 7977171 22.06 µM -2.51426278267934 0.076155089235583 no 3178 0.00596407589151876 1084 2236483 SGTC_504 lovastatin 124 µM -2.51675885012645 0.0759494862638996 no 3179 0.00592199316889946 1081 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_416 estradiol valerate 100 µM -2.52923895794521 0.0749278252084239 no 3180 0.00571550856891247 1086 13791 A steroid. SGTC_3238 9133470 49.47 µM -2.53321630290718 0.0746044398041172 no 3181 0.00565105931500709 1082 3534688 SGTC_2193 5925765 200 µM -2.53820746481377 0.0742001326131812 no 3182 0.00557109553897272 1082 877370 SGTC_2998 9066762 71.4286 µM -2.5461776528312 0.073557983294176 no 3183 0.00544548730804723 1081 4945196 SGTC_286 k060-0067 22.9 µM -2.54978397026147 0.0732688263290334 no 3184 0.0053894843919105 1087 5985051 SGTC_122 0236-0016 402.397 µM -2.55918217552727 0.0725193580830801 no 3185 0.00524593718667151 1071 6808838 SGTC_680 0417-1641 114 µM -2.56389664209403 0.0721456173969547 no 3186 0.0051752180932426 1082 2835990 SGTC_2318 6029776 164 µM -2.5750821799293 0.0712647890839186 no 3187 0.00501081361640775 1080 818325 SGTC_5 0352-0601 109.883 µM -2.57783534299832 0.0710492568930835 no 3188 0.00497106801775231 1073 762456 SGTC_1506 4226-2149 212 µM -2.58321784035615 0.0706293329797282 no 3189 0.00489417482965469 1085 991114 SGTC_961 1252-1571 372 µM -2.59193224835109 0.0699535124204391 no 3190 0.00477192824266868 1084 6813498 SGTC_2528 xanthyletin 44.79 µM -2.59240950378363 0.0699166444790252 no 3191 0.0047653125901084 1083 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1107 amlodipine 47 µM -2.59826571768545 0.0694654689863291 no 3192 0.00468479790527423 996 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_826 1683-5028 118 µM -2.60010620427632 0.0693241379250903 no 3193 0.00465974565345457 1089 722377 SGTC_1351 1496-0003 46.5 µM -2.60223920196334 0.0691606221395582 no 3194 0.00463086140303929 1087 3891978 SGTC_14 0354-0009 295 µM -2.61529066814605 0.0681665606624509 no 3195 0.00445757752099348 1092 1713507 SGTC_1528 arabinosylhypoxanthine 74.6 µM -2.63381964324776 0.0667742946317515 no 3196 0.00422151614915166 1078 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2062 5245942 200 µM -2.63461192059245 0.0667152571698545 no 3197 0.00421167643419843 1090 1376160 SGTC_981 1488-1094 54.9 µM -2.63813280971585 0.0664533825465113 no 3198 0.00416819631754965 1087 3449522 SGTC_2749 bexarotene 57.39 µM -2.64316392694455 0.0660805630242734 no 3199 0.00410676294494418 1080 82146 An retinoic acid receptor inhibitor. SGTC_278 4092-0821 23.9 µM -2.65024333184179 0.0655587066016677 no 3200 0.0040216908489695 1088 877900 SGTC_1643 st009866 20.2 µM -2.65149748239331 0.0654665913568979 no 3201 0.00400678552183061 1072 3156273 YOR207C RET1 SGTC_413 propylparaben 100 µM -2.6526142710897 0.0653846496277151 no 3202 0.00399355436777954 1081 7175 A pharmaceutical preservative. SGTC_1949 st076024 69.1 µM -2.67958882008857 0.0634295273004955 no 3203 0.00368563222077404 1084 2921930 SGTC_1764 st044502 93.5 µM -2.67974232398253 0.0634185329685838 no 3204 0.00368394263462212 1085 8407 SGTC_1134 3477-0009 42.5 µM -2.68218586071785 0.063243720438779 no 3205 0.00365714052706988 1077 3973534 SGTC_3310 9130229 44.1445 µM -2.68679031247928 0.0629153341935939 no 3206 0.00360711128406378 1086 7761258 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -2.68789096827361 0.0628370332646807 no 3207 0.00359524354898395 1086 229346 A bile salt which induces apoptosis. SGTC_2902 5787006 60.46 µM -2.69376518839182 0.0624204230852301 no 3208 0.00353249589754562 1077 591003 SGTC_3149 9097855 49.47 µM -2.69775175936079 0.0621389173525119 no 3209 0.00349047380570383 1084 25236625 YMR079W SEC14 SGTC_1909 st060837 51.5 µM -2.69797785626707 0.0621229815852637 no 3210 0.00348810404752483 1074 678937 SGTC_297 0986-0032 24 µM -2.69943872213925 0.0620200936450523 no 3211 0.00347282727693698 1086 2847425 SGTC_2926 9010726 65.15 µM -2.70095421860442 0.0619134986702041 no 3212 0.0034570427532965 1079 2994293 SGTC_259 usnic acid 108.925 µM -2.70112745429021 0.061901322960769 no 3213 0.00345524254264342 1091 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2713 st079149 53.4 µM -2.70710158506535 0.0614825790834557 no 3214 0.00339367424587967 1088 3103253 SGTC_2642 cholecalciferol 100 µM -2.70807452101573 0.0614145932144844 no 3215 0.00338374123704066 1085 9821465 A vitamin D precursor, similar to steriods. SGTC_2390 9097792 176.6 µM -2.7398911748982 0.0592235357467009 no 3216 0.00307297651918248 1089 4497149 SGTC_1041 0206-0046 107 µM -2.74110288253577 0.05914131913668 no 3217 0.00306166653606674 1092 50494 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -2.7480219262589 0.0586735629742111 no 3218 0.00299779997327717 1078 6708514 SGTC_2221 6807166 181.081 µM -2.7516428064714 0.0584299365753033 no 3219 0.00296485797267647 1090 674925 SGTC_1406 3909-7906 11.9 µM -2.76838711884918 0.0573136324888544 no 3220 0.00281672484269941 1070 X1406 SGTC_2794 7785382 27.27 µM -2.76951505394489 0.0572390431925294 no 3221 0.00280699049479497 1073 2205081 SGTC_2841 9004761 38.96 µM -2.77701143839792 0.0567452536539199 no 3222 0.0027430624131209 1080 2991039 SGTC_1937 st074714 47.2 µM -2.78120914914349 0.0564702180372978 no 3223 0.00270784171284546 1087 17250970 SGTC_1827 berberine 7.24 µM -2.78290279899107 0.0563595473357391 no 3224 0.00269374719800618 1057 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1569 carminic acid 40.6 µM -2.78548623518383 0.0561910633588679 no 3225 0.00267237545905858 1086 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1219 1469-0211 33.1 µM -2.79228008020649 0.0557498842742873 no 3226 0.00261690158314341 1082 6822282 SGTC_809 3998-0021 90 µM -2.79744868991991 0.0554160791569792 no 3227 0.00257539738425763 1081 715485 SGTC_2428 5615643 7.78 µM -2.81720232260335 0.0541548471871922 no 3228 0.00242219990914101 1080 2253075 SGTC_870 0573-2213 57.6 µM -2.81930624579294 0.0540218651627754 no 3229 0.0024063788294515 1085 3916321 SGTC_1304 1165-0502 251 µM -2.8196521918498 0.0540000238238611 no 3230 0.00240378635494726 1088 767425 SGTC_1780 st038448 24.544 µM -2.83569377277809 0.0529948922459625 no 3231 0.00228631333792088 1082 728868 YDL195W SEC31 SGTC_348 k064-0012 10.7 µM -2.83974455436348 0.0527434397305833 no 3232 0.00225748362976772 1082 5066323 SGTC_711 k292-0785 179 µM -2.84808979244608 0.0522283930060243 no 3233 0.00219912565881903 1078 4146315 SGTC_1759 st043059 70 µM -2.86187163022794 0.0513865667055715 no 3234 0.00210573722250828 1089 669426 SGTC_180 1486-1293 102.781 µM -2.87148283985233 0.0508059059889444 no 3235 0.00204275481583187 1085 4140536 SGTC_874 0599-0792 117 µM -2.87675439124248 0.0504896511021625 no 3236 0.0020089409501652 1086 765305 SGTC_1333 1482-0047 286 µM -2.89382994870419 0.0494759981323221 no 3237 0.00190287104786359 1090 3811116 SGTC_2455 5377712 9.75 µM -2.89773211469156 0.0492466501339201 no 3238 0.00187935743979898 1089 2243908 SGTC_1206 3978-0017 132 µM -2.90251242043096 0.0489668477881438 no 3239 0.00185091240205671 1077 3873677 SGTC_2488 5268135 45.7 µM -2.90503056276567 0.0488199666688738 no 3240 0.00183608620433101 1078 1270356 YLR208W SEC13 SGTC_77 0828-0286 12.516 µM -2.90762831254477 0.0486688113030179 no 3241 0.00182090453036584 1087 745345 SGTC_374 0880-0231 82.3 µM -2.91322608552481 0.0483443651589863 no 3242 0.00178857755295421 1070 6833587 SGTC_3010 9080089 71.4286 µM -2.91653287733346 0.0481535182838911 no 3243 0.0017697270905753 1092 17027233 SGTC_3075 9116269 49.47 µM -2.91669848203978 0.0481439765129533 no 3244 0.00176878782628004 1084 17015205 YNL244C SUI1 SGTC_2658 polymyxin b sulfate 77.05 µM -2.92772783584343 0.0475118882372123 no 3245 0.00170724395145647 1094 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -2.93066898558923 0.0473444596264177 no 3246 0.00169116488206919 1090 23665772 A membrane-active detergent. SGTC_2094 5332512 191.667 µM -2.93594663021019 0.0470452088030813 no 3247 0.00166265764102444 1093 755774 SGTC_2195 6536160 144.242 µM -2.943013062475 0.0466469077401272 no 3248 0.00162517351709414 1090 3834386 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -2.9541564196699 0.0460243122503978 no 3249 0.00156762524445952 1062 688669 SGTC_444 curcumin 90.4 µM -2.96304741416711 0.045532362378509 no 3250 0.00152304822168657 1082 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2591 skatole 100 µM -2.98891800730816 0.0441249251196642 no 3251 0.00139983625259499 1091 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1699 st031318 29.054 µM -2.99553195362271 0.0437707939177851 no 3252 0.00136983297667791 1091 5340658 SGTC_1901 st060216 58.6 µM -3.00895123167782 0.0430593303769878 no 3253 0.00131075596268119 1077 688792 SGTC_3243 9134147 49.47 µM -3.0205282508853 0.0424530728688308 no 3254 0.00126167083489865 1075 24282180 SGTC_2650 prasterone 100 µM -3.02674926205466 0.0421301578708523 no 3255 0.00123599457895001 1089 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3131 9127911 49.47 µM -3.04956428335713 0.0409628704586545 no 3256 0.00114586791121168 1084 45595681 SGTC_3340 9146634 11.102 µM -3.05546055070151 0.040665503640422 no 3257 0.00112357581325531 1087 4907387 SGTC_2261 9010538 184.68 µM -3.05777419317469 0.0405492992119409 no 3258 0.00111493767708761 1088 6457250 SGTC_2178 5812956 200 µM -3.05993510748338 0.0404410092621129 no 3259 0.00110692476774496 1089 5403383 SGTC_2307 7538926 6.34 µM -3.07389621750661 0.039747022751603 no 3260 0.00105641459379484 1082 96582 SGTC_641 4092-0595 30 µM -3.07956616410079 0.0394679567215101 no 3261 0.00103651159577078 1091 786260 SGTC_87 0100-0052 35.5 µM -3.08251366438851 0.0393235161658855 no 3262 0.0010263015328528 1093 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3026 9090633 49.47 µM -3.10759068586379 0.0381119521351777 no 3263 0.000943095530252011 1089 25236842 SGTC_1970 st070122 35.8 µM -3.1145772514522 0.0377798820770524 no 3264 0.000921043563999251 1092 102928 SGTC_457 grayanotoxin iii 135 µM -3.11544834439105 0.0377386452766399 no 3265 0.000918327569861899 1074 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2422 chlorphenesin carbamate 384.24 µM -3.11967610004632 0.0375390284636747 no 3266 0.000905250014770311 1081 2724 A muscle relaxant with antifungal properties. SGTC_2678 equilin 100 µM -3.12899450460559 0.0371020964100369 no 3267 0.000877027943713569 1088 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_765 1319-0117 244 µM -3.13909985092015 0.036632972138244 no 3268 0.000847338455561101 1086 3487746 YGL099W LSG1 SGTC_2835 9006588 71.43 µM -3.14274632063884 0.0364648866606109 no 3269 0.000836854120530977 1068 2345538 SGTC_1393 3470-5649 58.2 µM -3.16549525771658 0.0354304627777154 no 3270 0.000774095927484031 1092 4108395 SGTC_2352 9027995 87.8 µM -3.18242883300187 0.0346761952486297 no 3271 0.000730227012703577 1088 2997347 SGTC_2424 5537928 59.2 µM -3.23296816404029 0.0325031069697075 no 3272 0.000612556073221581 1084 5382802 SGTC_3044 9093193 49.47 µM -3.23371478375933 0.0324718659004965 no 3273 0.000610957088112937 1087 25236277 SGTC_1733 st037357 54.9 µM -3.23823520045061 0.0322832451478866 no 3274 0.000601358059442325 1090 1272339 YGL099W LSG1 SGTC_823 0417-1665 178 µM -3.2682499151965 0.0310536499597299 no 3275 0.000541073824673465 1093 3429856 SGTC_253 dyclonine 31.25 µM -3.26969200981874 0.0309955617667677 no 3276 0.000538323198284064 1095 3180 An oral anasthetic. SGTC_1738 st035555 74 µM -3.2925037275847 0.0300885952922129 no 3277 0.000496497907447374 1089 5331140 SGTC_3249 9135183 49.47 µM -3.30143743638486 0.0297394494992397 no 3278 0.000480953923390313 1077 4902779 SGTC_1181 1222-0449 220 µM -3.30700965784832 0.0295233839156566 no 3279 0.000471488204321754 1093 658318 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -3.31262938054111 0.0293067978344587 no 3280 0.000462116832041506 1090 521171 SGTC_3008 9078912 71.4286 µM -3.31643773941642 0.0291607737471321 no 3281 0.000455864498408158 1091 16648731 SGTC_3203 9113543 49.47 µM -3.32269445720853 0.0289221845867356 no 3282 0.000445762540258139 1089 17018012 SGTC_530 4358-1714 28 µM -3.33310408703867 0.0285288276684353 no 3283 0.000429414030061263 1090 1564641 SGTC_2976 9009005 19.48 µM -3.34622798241348 0.0280392569227743 no 3284 0.000409595058447977 1087 2993148 SGTC_3014 9081533 49.47 µM -3.34976782501765 0.0279084119880799 no 3285 0.000404396614404586 1093 21367265 SGTC_1365 1672-3266 55.4 µM -3.35204356120955 0.0278245617349357 no 3286 0.000401086978873649 1089 6415873 SGTC_1336 1486-0901 104 µM -3.36983000944508 0.0271764186274871 no 3287 0.000376072839230433 1091 5006114 SGTC_2689 tacrolimus 100 µM -3.37729070370753 0.0269083238700908 no 3288 0.000366018195843799 1078 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -3.39583157399128 0.0262516190363759 no 3289 0.000342102235935723 1092 4174840 SGTC_2793 7325131 81.82 µM -3.40969868434386 0.0257692603793598 no 3290 0.000325173439257775 1093 4176441 SGTC_3284 9108171 64.8615 µM -3.4188322395361 0.0254556247495887 no 3291 0.000314452438751583 1090 8687505 SGTC_2286 7945697 125 µM -3.43470130399684 0.0249183032390514 no 3292 0.000296603647451315 1084 1245733 SGTC_3142 9086498 49.47 µM -3.45822546557579 0.0241393039579502 no 3293 0.000271873064233231 1076 25236367 SGTC_2953 9074162 66.49 µM -3.45840004663751 0.0241336000958188 no 3294 0.000271696930708435 1090 16451992 SGTC_1173 0443-0020 122 µM -3.4610518038446 0.024047101758573 no 3295 0.000269034629836957 1094 5331295 SGTC_1750 st081859 2.357 µM -3.50181269272427 0.0227499542164333 no 3296 0.000231052181870495 1085 5291695 SGTC_601 0986-0029 62.9 µM -3.52087484444599 0.022163870542769 no 3297 0.000215062789560731 1092 24747981 SGTC_1921 5740136 50 µM -3.52691462510999 0.0219808508856042 no 3298 0.000210216154090322 1091 1774243 SGTC_178 4092-0806 87.505 µM -3.52727441026803 0.0219699889293339 no 3299 0.000209930687212078 1089 2169044 SGTC_1928 4'-methoxychalcone 40.3 µM -3.55388864403865 0.021178973496679 no 3300 0.000189789948451319 1090 641818 SGTC_415 dibenzyl ketone 100 µM -3.56403962949787 0.0208836839565777 no 3301 0.000182595391506973 1092 7593 SGTC_2232 chlorophetanol 41.5365 µM -3.57611297264035 0.0205370183201674 no 3302 0.000174370495446971 1092 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_263 alizarin 107.927 µM -3.60669414539042 0.0196806813872343 no 3303 0.000155061422143777 1087 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_649 1123-0311 367 µM -3.61886487680154 0.0193484095370687 no 3304 0.000147949039948308 1093 693629 YIL048W NEO1 SGTC_3153 9100258 49.47 µM -3.61917871551164 0.0193399048911648 no 3305 0.000147769744210911 1090 25236848 SGTC_3083 9117465 49.47 µM -3.67045902826097 0.0179922804836185 no 3306 0.000121057639121247 1094 16420915 SGTC_3085 9117376 49.47 µM -3.67434731029599 0.0178934465090305 no 3307 0.000119229096044952 1089 16480349 SGTC_1934 st074720 32.6 µM -3.67976789161309 0.0177564368636502 no 3308 0.000116723168764158 1091 17250992 SGTC_2867 9039098 71.43 µM -3.69499537694002 0.017376329280828 no 3309 0.000109945394102574 1090 6463460 SGTC_467 ro 31-8220 72.8 µM -3.73589370304706 0.0163896549784607 no 3310 9.35248377216844e-05 1090 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3004 9076122 71.4286 µM -3.75276609786034 0.0159968091690555 no 3311 8.74470132295922e-05 1093 44782551 SGTC_2498 4'-Methoxychalcone 54.63 µM -3.76224904426104 0.0157795781282526 no 3312 8.41961213052468e-05 1094 641818 YHR062C RPP1 SGTC_2454 5-benzylidenerhodanine 10.36 µM -3.78877633833723 0.01518529327518 no 3313 7.56955662686611e-05 1093 1273210 SGTC_1383 3049-0032 20.7 µM -3.80805733954802 0.0147655056060144 no 3314 7.00314000222356e-05 1091 712864 SGTC_1737 st035557 69.7 µM -3.80862863315265 0.0147532211410726 no 3315 6.98698229833629e-05 1093 5716916 SGTC_2468 5987765 72.9 µM -3.86708721677091 0.0135417923709932 no 3316 5.50715222069166e-05 1095 26772094 SGTC_1284 0929-0043 16 µM -3.9070300351523 0.0127643138393564 no 3317 4.67187713367615e-05 1094 1239883 SGTC_3207 9114163 49.47 µM -3.93238673755817 0.0122910483462886 no 3318 4.20533054766061e-05 1092 849233 SGTC_1270 0831-1170 17.3 µM -3.97563629212177 0.011518863823996 no 3319 3.50956653952736e-05 1093 6764716 SGTC_658 3253-0951 102 µM -4.04318018021957 0.0103971939972736 no 3320 2.63655333590014e-05 1094 1184878 SGTC_3108 9121785 49.47 µM -4.0434562422856 0.0103928122190881 no 3321 2.63344947639076e-05 1081 17140271 SGTC_1681 tripelennamine 100 µM -4.04856279801555 0.0103120485250107 no 3322 2.57665538673711e-05 1090 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3305 9127027 53.8275 µM -4.08541086563201 0.0097453236469022 no 3323 2.19994445544614e-05 1093 41905295 SGTC_1940 st075990 51.1 µM -4.14003444548838 0.00895530223003931 no 3324 1.73626837520449e-05 1095 1084979 SGTC_581 0958-0271 211 µM -4.21381102056782 0.00797761336232621 no 3325 1.25548703127556e-05 1095 4591145 SGTC_74 000s-0487 160.283 µM -4.27511621746295 0.00723789462458608 no 3326 9.55188080619818e-06 1092 677548 SGTC_2900 5328528 85.29 µM -4.28295209333339 0.0071478458571938 no 3327 9.22149459157046e-06 1088 795359 SGTC_1597 7-benzyloxygramine 47.5 µM -4.28806317220715 0.00708964397042808 no 3328 9.0118919399936e-06 1089 260807 SGTC_1520 flindersine 88 µM -4.329386589954 0.00663423367590957 no 3329 7.47626242544289e-06 1093 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2539 epi(13)torulosol 80 µM -4.34054050841783 0.00651582962889904 no 3330 7.10663311760664e-06 1088 6708597 SGTC_2982 9019404 25.97 µM -4.37988788998509 0.00611292958058769 no 3331 5.93701911194165e-06 1094 22333232 SGTC_159 3970-0959 50 µM -4.38350995594159 0.00607697476166812 no 3332 5.83911546341785e-06 1092 6615653 SGTC_2588 indole-3-carbinol 100 µM -4.38471690005091 0.00606503560110281 no 3333 5.80683573301615e-06 1094 3712 Induces cell cycle arrest. SGTC_700 3453-2283 142 µM -4.65150111770223 0.00388459457051218 no 3334 1.647637442505e-06 1095 565664 SGTC_1291 0993-0025 5.79 µM -4.6624986277469 0.00381213523153067 no 3335 1.56196585337206e-06 1095 4353356 SGTC_990 3985-0011 41.3 µM -4.68802909139736 0.00364857292118972 no 3336 1.37924406197505e-06 1095 5399565 YGL099W LSG1 SGTC_344 k064-0035 6.43 µM -4.92435295246722 0.00240841770540785 no 3337 4.23199736339839e-07 1092 5088750 SGTC_3211 9128781 49.47 µM -4.97873149775521 0.00218360529060677 no 3338 3.20011794246942e-07 1090 17194361 SGTC_1775 st081588 35.1725 µM -5.01593806458242 0.00204093342302436 no 3339 2.63876645573664e-07 1092 1426443 YGL099W LSG1 SGTC_1335 1486-0900 202 µM -5.04127552344338 0.00194867458993963 no 3340 2.31219544471953e-07 1094 X1335 SGTC_3302 9125395 16.351 µM -5.10958526843425 0.0017185082389186 no 3341 1.61433376525668e-07 1095 17599668 SGTC_3303 9125618 40.5795 µM -5.21598987120658 0.00140890161204897 no 3342 9.14190834391659e-08 1094 22695467 SGTC_2460 5552655 174.22 µM -5.29064740380358 0.00122305472386872 no 3343 6.09420715412745e-08 1095 5401989 SGTC_2038 4100038 30.985 µM -5.57637934639129 0.000700511440789662 yes 3344 1.22788049906605e-08 1091 3596803 SGTC_651 3253-0966 34.4 µM -5.58869893674466 0.000683491430013939 yes 3345 1.1438859392511e-08 1095 781462 SGTC_1522 st012842 45.6 µM -5.62062507108898 0.000641143443717771 yes 3346 9.51338943180741e-09 1091 3491067 YOR116C RPO31 SGTC_1283 0922-0125 16.4 µM -5.78704943368181 0.000457013802949666 yes 3347 3.58167516509405e-09 1095 3360884 SGTC_1574 spiramycin 23.7 µM -5.79088471826164 0.000453416165577718 yes 3348 3.50083119799852e-09 1095 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1269 0831-0796 3.05 µM -6.12159953380539 0.000225445907459672 yes 3349 4.63203099272129e-10 1095 927758 SGTC_3068 9116768 49.47 µM -6.22417549402323 0.00018026323329694 yes 3350 2.42047489971165e-10 1094 41904888 SGTC_2056 5235370 200 µM -6.87402843593834 4.04758531057644e-05 yes 3351 3.1206879127462e-12 1094 5511916