SGTCid condition conc unit RGR1|YLR071C.score RGR1|YLR071C.strain.pval RGR1|YLR071C.strain.significant RGR1|YLR071C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2052 5265182 7.135 µM 5.3064253759426 1.2384231516768e-08 yes 1 5.58979490519217e-08 2 1239884
SGTC_2948 9070189 9.45 µM 4.87498751587593 1.51348308325419e-07 yes 2 5.4407668215123e-07 6 6473636 YDL196W YDL196W
SGTC_453 enantio-paf c16 10 µM 4.6749752294978 4.5147100317256e-07 yes 3 1.46994550897392e-06 16 13871343 A lipid and platelet activating factor
SGTC_2944 9067346 25.62 µM 4.52526780947665 9.94905833314219e-07 yes 4 3.01595366597953e-06 8 6473075
SGTC_1260 0700-1617 7.75 µM 4.18626514160588 5.45238477131399e-06 yes 5 1.41791034087667e-05 6 2853078
SGTC_1256 0570-0116 285 µM 4.11889888746045 7.53527158406172e-06 yes 6 1.90343566627264e-05 5 410638
SGTC_2785 7756463 72.73 µM 3.95386692582995 1.63124692390171e-05 yes 7 3.84490946290171e-05 19 2201551
SGTC_568 1193-0097 7.48 µM 3.47982520314437 0.00012786718285996 yes 8 0.00025087051106967 30 3646150
SGTC_444 curcumin 90.4 µM 3.33750634394644 0.000226617472077292 yes 9 0.000422668960357144 25 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_969 1313-0238 134 µM 3.23693576827907 0.000335274788504912 yes 10 0.000604103015060297 34 5212874
SGTC_1834 st055981 52.8 µM 3.1878249558797 0.000404399853053598 yes 11 0.00071673642973353 21 471719 YDL150W RPC53
SGTC_127 0180-0333 59.125 µM 3.17923011368115 0.000417779242990572 yes 12 0.000738334054819958 3 771601
SGTC_2935 9038016 29.96 µM 3.17711200714718 0.000421138927663536 yes 13 0.000743747877007758 14 6463195
SGTC_1371 2421-0008 32.7 µM 3.17673513738779 0.000421739328189033 yes 14 0.000744714970109263 36 2827552
SGTC_227 fluconazole 33.516 µM 3.16156497475343 0.000446576873216654 yes 15 0.000784619024629721 59 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1369 1866-0067 208 µM 3.15451567086462 0.000458573916131035 yes 16 0.000803823721110457 14 3531355
SGTC_1079 idarubicin 2.36 µM 3.09194749331953 0.000578920329766883 yes 17 0.000994240091372553 13 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_431 k089-0097 107 µM 3.02979586979791 0.000726800438718464 yes 18 0.00122359538712382 26 5499420
SGTC_2896 9052656 71.43 µM 3.01247383339997 0.000773823471391359 yes 19 0.00129563887436219 32 6469436
SGTC_1088 bifonazole 369 nM 2.96924613950076 0.000903652326476159 yes 20 0.00149265682516705 9 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1910 st062352 60.4 µM 2.96638214260105 0.000912924099039991 yes 21 0.00150662913068253 11 2245730
SGTC_761 k216-0224 480 µM 2.93883285914706 0.00100668166904022 no 22 0.00164725342990498 20 1340404
SGTC_772 k072-0172 35.3 µM 2.92922299681006 0.00104141210351241 no 23 0.00169905269589381 9 5861980
SGTC_1027 k015-0025 8.67 µM 2.88287854409358 0.00122485043092684 no 24 0.00197029673327011 14 3598955
SGTC_65 0798-0905 34.986 µM 2.88199108966051 0.00122863523832773 no 25 0.00197585454049722 22 3602145
SGTC_1086 cerivastatin 2.18 µM 2.78819693564358 0.00169457046488335 no 26 0.00265011564750642 11 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2046 4110841 106 µM 2.7874437253055 0.00169888955183189 no 27 0.0026562840201595 30 44119630 YMR134W ERG29
SGTC_955 1216-0110 33 µM 2.76041640268599 0.00186066154306702 no 28 0.00288638650492717 21 3619719
SGTC_1510 1123-0200 71.5 µM 2.68895774199856 0.00235802542045114 no 29 0.00358377460146266 38 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1010 4112-3296 15.2 µM 2.68891677174829 0.0023583421874553 no 30 0.00358421446791378 24 704384
SGTC_124 0136-0217 7.121 µM 2.6542477300337 0.00264061921951074 no 31 0.0039742724221602 52 3976905
SGTC_3137 9097352 49.47 µM 2.65084139027247 0.00266993836705257 no 32 0.00401457686363473 29 44120435
SGTC_314 1671-0008 2.74 µM 2.55855673864812 0.00358485403350306 no 33 0.00525538332032126 37 3913060
SGTC_1073 triclabendazole 3.09 µM 2.54663971849659 0.00372154375260293 no 34 0.0054382830666737 19 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2369 9071472 200 µM 2.53405028424585 0.00387100668776548 no 35 0.00563762753129638 21 17296037
SGTC_1982 st072467 71.9 µM 2.50924623020285 0.00418131164301346 no 36 0.00604945572255335 33 3163533
SGTC_134 0269-0018 6.916 µM 2.49752974414375 0.00433548120909883 no 37 0.00625309864483917 47 4378915
SGTC_295 k015-0027 31 µM 2.47205117576605 0.00468839646835724 no 38 0.00671701418838458 15 3887424
SGTC_908 3448-7491 47.7 µM 2.43576352118334 0.00523526741647619 no 39 0.00743019799681427 30 1203031
SGTC_1143 3454-2408 5.08 µM 2.38724185770721 0.00605490036272536 no 40 0.00848765978136397 24 X1143
SGTC_2096 5468907 200 µM 2.37580522172632 0.00626391768384964 no 41 0.00875535173837951 31 759785
SGTC_1749 st037932 54.2 µM 2.36481752909352 0.0064707220298705 no 42 0.00901947813520053 37 594497
SGTC_1557 sumaresinolic acid 42.3 µM 2.36284274765994 0.00650852401032556 no 43 0.00906768149651158 22 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_120 rhodamine 6G 52.259 µM 2.35953455322645 0.00657228850043779 no 44 0.00914893837393141 73 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_194 1486-1323 56.904 µM 2.35853576246843 0.00659164816483843 no 45 0.00917359593335604 43 5178754
SGTC_2483 5729050 27.16 µM 2.34985438124905 0.00676205527903523 no 46 0.00939037840891131 38 2865180
SGTC_1255 0566-0045 221 µM 2.31862110184128 0.00740776051220546 no 47 0.0102077949518867 45 2788469
SGTC_637 1181-0519 7.26 µM 2.31108364101728 0.00757149947157148 no 48 0.0104141176991771 43 6252091 YGR060W ERG25
SGTC_513 4245-1575 41.7 µM 2.31107452788141 0.00757169935330673 no 49 0.0104143693368768 81 719745
SGTC_1917 st066507 28.5 µM 2.30419872025517 0.00772383980471507 no 50 0.0106057455094314 47 3156428
SGTC_3073 9114972 49.47 µM 2.29409908395583 0.00795219156901516 no 51 0.0108924039883189 28 41905075
SGTC_116 0155-0182 31.788 µM 2.28933196586737 0.00806202301270136 no 52 0.0110300358836833 29 771486
SGTC_1785 bathophenanthroline 24 µM 2.27711025930659 0.00834971623946538 no 53 0.0113898211026111 68 72812 An iron chelator.
SGTC_2543 pimpinellin 60.67 µM 2.27176317321431 0.00847839299381875 no 54 0.0115504091358498 28 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1860 st056228 74.6 µM 2.25971231950931 0.00877479317345482 no 55 0.011919555602611 46 688679
SGTC_2015 5119600 184 µM 2.25419184527904 0.00891358079727037 no 56 0.0120920507941513 54 2828786
SGTC_2418 pentamidine 31.67 µM 2.2482295015855 0.00906563415696932 no 57 0.0122807797074366 56 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1161 k007-0610 110 µM 2.23982688855133 0.00928377437983197 no 58 0.0125510817691553 74 5843850
SGTC_42 0133-0086 60.653 µM 2.21459501335523 0.00996665614924292 no 59 0.0133939373039847 58 162923 Model of phenazepam hydroxylation.
SGTC_2840 9008771 71.43 µM 2.21310812197926 0.0100082318940706 no 60 0.0134450961458532 16 2992978
SGTC_63 0099-0242 26.702 µM 2.21268080262099 0.010020208362521 no 61 0.0134598299166361 61 3898502 YLR359W ADE13
SGTC_1314 1222-0010 41.1 µM 2.20871959313007 0.0101318258058427 no 62 0.0135970753778561 34 3526027
SGTC_3075 9116269 49.47 µM 2.19821135118727 0.0104331941084657 no 63 0.0139670240737245 45 17015205 YNL244C SUI1
SGTC_70 0141-0289 43.283 µM 2.18712144792203 0.0107596887074045 no 64 0.0143668296489456 59 352408
SGTC_3297 9117502 71.43 µM 2.18042484465133 0.0109611193651696 no 65 0.0146129920866893 13 7453720
SGTC_3260 9137109 49.47 µM 2.15648904430495 0.0117081558840061 no 66 0.0155227491678861 27 17478346
SGTC_1778 st046819 58.9 µM 2.15642809142183 0.011710113281614 no 67 0.0155251265640684 50 671715
SGTC_103 0844-0104 51.839 µM 2.14259164342264 0.0121618624678406 no 68 0.0160729513815876 107 5375804
SGTC_404 fumagillin 50 µM 2.13108056163704 0.0125491253726807 no 69 0.0165412529073775 37 12015870 A methionine aminopeptidase binder.
SGTC_34 0469-0683 81.75 µM 2.13001832629977 0.0125853939678395 no 70 0.0165850501973207 40 3690923
SGTC_1920 st075728 45.7 µM 2.12933747879502 0.012608688276218 no 71 0.0166131745516604 43 3400306
SGTC_97 0535-0701 19.132 µM 2.11464562519654 0.0131205201667394 no 72 0.017230080969073 47 2832013 YGL099W LSG1
SGTC_14 0354-0009 295 µM 2.09767081690857 0.0137341529901979 no 73 0.0179671172727955 35 1713507
SGTC_3008 9078912 71.4286 µM 2.09002575878554 0.0140185074976274 no 74 0.0183077429328133 37 16648731
SGTC_2322 7413319 38.22 µM 2.08142159855785 0.0143445911279681 no 75 0.0186976667119249 78 1840400
SGTC_1099 5-nonyloxytryptamine 2.85 µM 2.06850138604762 0.0148465070812893 no 76 0.0192964502051306 49 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_661 1304-0007 33.6 µM 2.06701982516106 0.0149050156532211 no 77 0.019366142953338 41 3117130
SGTC_3157 9099274 49.47 µM 2.06012648621159 0.0151798556900318 no 78 0.0196932252098584 41 17217662
SGTC_1105 epirubicin 18.1 µM 2.05258872034175 0.0154853617548084 no 79 0.0200562412159783 63 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_262 fenpropimorph 62.5 µM 2.0392175578366 0.016040288748519 no 80 0.0207141596651924 69 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2069 5228469 200 µM 2.0199835172671 0.0168683790174896 no 81 0.0216925486353598 51 2835210
SGTC_3142 9086498 49.47 µM 2.01417057308545 0.0171257313262552 no 82 0.0219958140413268 99 25236367
SGTC_3040 9091894 49.47 µM 2.00256235438343 0.0176497056194191 no 83 0.0226121419908313 38 25236966
SGTC_3175 9106517 49.47 µM 1.99782424538612 0.0178674743771661 no 84 0.0228678589091034 48 41468073
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.98755270563286 0.0183474455503424 no 85 0.0234305906680762 62 65057 A dermal irritant. YDR527W RBA50
SGTC_1959 st077091 55.8 µM 1.98227114315033 0.0185984907156718 no 86 0.0237244509631616 83 821356 YKL052C ASK1
SGTC_2928 9011484 9.79 µM 1.98132399537035 0.0186438187468929 no 87 0.0237774755604217 80 2994751
SGTC_3151 9099821 49.47 µM 1.96565832575259 0.0194072855092609 no 88 0.0246690458995414 64 17174189
SGTC_293 4049-0273 38.5 µM 1.96111804569728 0.019633460106572 no 89 0.0249326270548441 52 1380311
SGTC_2187 6125751 200 µM 1.95835010773887 0.0197724404163357 no 90 0.0250944724373456 61 874498
SGTC_1031 k035-0009 16 µM 1.94104593672039 0.0206603567891127 no 91 0.026126352868718 43 5180959
SGTC_2837 9008476 45.46 µM 1.9350255417334 0.0209770936370781 no 92 0.0264935807239173 56 2992805
SGTC_2174 5790901 200 µM 1.93307886341841 0.0210803848697433 no 93 0.0266132417196464 66 786020
SGTC_1397 3532-0190 20.1 µM 1.93014590323444 0.0212368208820088 no 94 0.0267943810905016 37 5322280
SGTC_2378 9074213 121.43 µM 1.9208979804923 0.0217365229324384 no 95 0.0273722852136251 78 657714
SGTC_1635 st007035 42.4 µM 1.91972124964915 0.0218008130795153 no 96 0.0274465593291886 73 3716403
SGTC_11 0438-0307 1.3 µM 1.91917408584027 0.0218307617815387 no 97 0.0274811529761388 67 4011476
SGTC_2327 6189656 200 µM 1.9158071899502 0.0220158126522167 no 98 0.0276948211144747 47 5349088
SGTC_1329 1447-1697 50.6 µM 1.90612723544293 0.0225552324971299 no 99 0.028316849953423 49 2840515
SGTC_632 0781-2353 4.65 µM 1.89916474406951 0.0229500742746286 no 100 0.0287714093192435 99 6811515 YHR007C ERG11
SGTC_1355 1499-0035 1.68 µM 1.89378117380666 0.0232593528484087 no 101 0.0291270307652578 51 1548538
SGTC_1947 st076332 61.6 µM 1.88671362118032 0.0236706931618882 no 102 0.0295994272985783 55 24208416
SGTC_1190 1486-1332 13 µM 1.88659391025063 0.0236777128356819 no 103 0.0296074832423037 56 4150046
SGTC_1300 1094-0077 113 µM 1.88458797316447 0.0237955987223475 no 104 0.029742743654653 59 5532636
SGTC_913 3487-1245 167 µM 1.86178908689872 0.0251704750673191 no 105 0.031316412681713 74 4016153
SGTC_2053 5265679 138 µM 1.86022225052295 0.0252673586624379 no 106 0.0314270441406407 65 764595
SGTC_339 3091-4833 71.4 µM 1.85580116670642 0.0255424175411733 no 107 0.0317409521130981 94 3240077
SGTC_845 0330-0138 4.51 µM 1.84746221138196 0.0260680538074584 no 108 0.0323400900043102 62 9039800
SGTC_953 1188-0045 9.7 µM 1.83189103808051 0.0270737897441082 no 109 0.0334838280123002 71 6144426
SGTC_1465 k213-0056 144 µM 1.82642249776682 0.0274345969923198 no 110 0.033893322792184 77 24048857 YMR208W ERG12
SGTC_2078 5212016 200 µM 1.82604607303688 0.0274595798130582 no 111 0.0339216610782472 53 1899708
SGTC_766 1391-0721 126 µM 1.820468370815 0.0278319929713739 no 112 0.0343438543560323 72 1020919 YIL115C NUP159
SGTC_1183 1254-0324 198 µM 1.81633964867418 0.0281103625034862 no 113 0.0346591433826104 48 5799357
SGTC_412 gemfibrozil 100 µM 1.80531009656567 0.0288653917937965 no 114 0.0355130852871567 64 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.80453064002802 0.0289193813522141 no 115 0.0355740801525193 67 551469
SGTC_3345 9148410 3.559 µM 1.80031405051471 0.0292129032137943 no 116 0.0359055317821692 51 4903596
SGTC_1140 3229-1848 2.98 µM 1.79587568480653 0.0295245321452307 no 117 0.0362571451647791 50 2849525
SGTC_1974 st069448 26.9 µM 1.79206886093336 0.0297940127201505 no 118 0.036560968087228 54 6323587 YNR016C ACC1
SGTC_2402 5553605 200 µM 1.79190671666372 0.029805535881115 no 119 0.0365739549441994 69 6758546
SGTC_598 3937-0236 20.2 µM 1.78428708563861 0.0303512264633317 no 120 0.0371885138252874 68 1379313
SGTC_859 0439-0102 54.6 µM 1.78129086096318 0.0305680610322309 no 121 0.037432473355946 92 610143
SGTC_1656 st012921 11 µM 1.77950355608832 0.0306980168332907 no 122 0.0375786212019554 59 6732821
SGTC_1681 tripelennamine 100 µM 1.77719723574466 0.0308663862042727 no 123 0.0377678970547164 57 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3016 9080866 49.47 µM 1.76856581787912 0.0315033066104697 no 124 0.0384831796701499 59 17066299
SGTC_1018 4259-0013 28.1 µM 1.76376997266886 0.0318618667113428 no 125 0.0388853574468921 66 6801262
SGTC_1513 0337-0559 19 µM 1.75546488703501 0.0324907647097523 no 126 0.0395899108100786 63 775073
SGTC_2080 5212524 12.4 µM 1.75404708920581 0.0325991432347935 no 127 0.039711219381243 71 260183
SGTC_481 bay k-8644 50 µM 1.75093961559437 0.0328377261246753 no 128 0.0399781559757677 65 2303 A calcium channel antagonist.
SGTC_90 0870-0863 4.608 µM 1.74882698469511 0.0330007483645965 no 129 0.0401604654023773 80 1738164
SGTC_199 4063-0024 41.6 µM 1.74644826002142 0.0331851014968181 no 130 0.0403665451242329 29 306215
SGTC_2344 7990960 76.95 µM 1.74614508384583 0.0332086587375157 no 131 0.0403928722423628 105 140813
SGTC_649 1123-0311 367 µM 1.73812960573179 0.0338364863992592 no 132 0.0410939896550789 77 693629 YIL048W NEO1
SGTC_1611 st001856 99.4 µM 1.73556399065586 0.0340394941269177 no 133 0.0413204788284819 82 647478
SGTC_1992 st073643 23.3 µM 1.73344948449446 0.0342075591970132 no 134 0.0415079043598382 68 3161292
SGTC_2504 purpurogallin 52.29 µM 1.73261545399172 0.034274036882355 no 135 0.0415820203077661 59 5281571 An antioxidant.
SGTC_2859 9028643 45.46 µM 1.72986258036052 0.0344942129551309 no 136 0.0418274151298153 50 17151580
SGTC_3299 9121982 43.1275 µM 1.71818122295657 0.0354414566254669 no 137 0.0428817826794231 63 17594604 YPL160W CDC60
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.71677521133113 0.0355568950572808 no 138 0.043010125921676 73 7104
SGTC_1284 0929-0043 16 µM 1.71625195230993 0.0355999350656371 no 139 0.0430579691051968 72 1239883
SGTC_2075 5212009 200 µM 1.71511578468434 0.035693536139614 no 140 0.0431620004399183 59 780898
SGTC_2302 7771753 200 µM 1.71304370719214 0.0358647597351895 no 141 0.0433522495136767 76 2203047
SGTC_1977 st070720 65.3 µM 1.71212563677549 0.0359408382000882 no 142 0.0434367588907586 44 682188
SGTC_372 0155-0182 15.9 µM 1.71194929425129 0.0359554664393841 no 143 0.0434530066270119 62 771486
SGTC_1500 4488-1866 171 µM 1.7083369653566 0.0362561967005797 no 144 0.0437869180367541 63 2900003
SGTC_966 1300-0360 30.2 µM 1.70557049080103 0.0364878984106258 no 145 0.0440440387374388 93 70588
SGTC_1138 3761-0006 1.03 µM 1.70328086324559 0.0366805776695752 no 146 0.0442577600486926 42 12061087
SGTC_1876 myriocin 605 nM 1.70079527646294 0.0368906888144083 no 147 0.0444907182863517 84 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_950 1165-0508 94.1 µM 1.70006298752409 0.0369527778461829 no 148 0.044559539157172 72 6148369
SGTC_1171 0368-0077 21.4 µM 1.699227435278 0.0370237266488976 no 149 0.0446381694852344 88 3239779
SGTC_480 am 92016 50 µM 1.69891514953464 0.037050272169975 no 150 0.0446675860651735 86 2129 K+ channel blocker.
SGTC_173 1273-0061 2.693 µM 1.69012178317007 0.0378041516718882 no 151 0.0455023291324218 109 2847414 YPL266W DIM1
SGTC_530 4358-1714 28 µM 1.68757897018719 0.0380244727088623 no 152 0.0457460394724818 101 1564641
SGTC_2939 9044578 71.43 µM 1.6766050297128 0.0389873504424538 no 153 0.0468098712905347 70 2653634
SGTC_192 3455-0609 60.9 µM 1.67191958106075 0.0394044658006665 no 154 0.0472700905082269 68 3769639
SGTC_851 0394-0702 453 µM 1.66745489743013 0.0398052989330319 no 155 0.0477119928222512 109 762646
SGTC_1773 st048542 73.5835 µM 1.66149719278793 0.0403453294892294 no 156 0.0483068161251718 132 3237138
SGTC_1402 3909-7673 35.9 µM 1.65072630515142 0.0413367394824084 no 157 0.0493972369869129 63 5328014
SGTC_2476 5806916 10.51 µM 1.64894922405227 0.0415021935572315 no 158 0.0495790187446041 67 2870194
SGTC_335 4077-0256 27.6 µM 1.64453020344707 0.0419159507692525 no 159 0.0500333653637955 94 3121989
SGTC_1406 3909-7906 11.9 µM 1.64062300287101 0.0422845618072938 no 160 0.050437848493725 73 X1406
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.63537036287031 0.0427842316353754 no 161 0.0509857156935636 42 88881 An O-methylated flavonoid and antioxidant.
SGTC_2139 5578692 56.4705 µM 1.63533894594807 0.0427872345403329 no 162 0.0509890067733598 96 650991 YMR113W FOL3
SGTC_2862 9027634 71.43 µM 1.62838004756853 0.0434565922791114 no 163 0.0517221628264513 82 5012562
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.61945868562458 0.0443270513333194 no 164 0.0526743044038633 87 390807
SGTC_270 tamoxifen 5.46 µM 1.61745423727497 0.0445245463247871 no 165 0.0528901331483525 89 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1689 st020265 53.493 µM 1.61241510165349 0.0450241761589809 no 166 0.0534358204027513 85 5758320 YPR016C TIF6
SGTC_2699 st077704 54.6 µM 1.60906711039496 0.0453586171020964 no 167 0.0538008339894872 75 645852
SGTC_2328 6201408 200 µM 1.60897606853824 0.0453677393793705 no 168 0.0538107873038195 103 2890418
SGTC_2662 daunorubicin 22.37 µM 1.60885968227629 0.0453794032824908 no 169 0.0538235135642186 96 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1925 st057770 10.1 µM 1.6083592162966 0.0454295860595715 no 170 0.0538782641970393 80 5989122
SGTC_779 1360-0071 233 µM 1.60448517157999 0.0458195562171637 no 171 0.0543035752154325 86 7566
SGTC_2382 9035899 200 µM 1.60127301704173 0.0461449351060858 no 172 0.0546582313314165 99 6462679
SGTC_1494 4358-1428 177 µM 1.59953078585998 0.0463221911500383 no 173 0.0548513568630261 88 1564571
SGTC_2043 5101342 149 µM 1.59815678110318 0.0464623687642057 no 174 0.0550040447375677 82 678451
SGTC_2716 st080858 38.6235 µM 1.59368509163962 0.0469209345387355 no 175 0.0555032925099476 64 5296050
SGTC_3003 9075612 71.4286 µM 1.59242821323686 0.0470504771613248 no 176 0.0556442605624799 80 6501993
SGTC_1671 st016596 74.5 µM 1.59108169297026 0.0471895769050653 no 177 0.0557955959723297 89 2829167
SGTC_1907 st060210 83.7 µM 1.5892763339562 0.0473765931795629 no 178 0.0559990096604087 93 688793
SGTC_1381 2324-0066 62.1 µM 1.58919011759915 0.0473855391276834 no 179 0.0560087384575122 95 10885928
SGTC_1464 k208-0027 110 µM 1.58782194311759 0.0475276843704888 no 180 0.0561633040443317 105 X1464
SGTC_1188 1403-0014 4.57 µM 1.58546837951778 0.0477730047379815 no 181 0.0564299778652375 90 9614867
SGTC_1495 4469-0029 237 µM 1.57653867036881 0.0487130147364491 no 182 0.0574508570484754 73 793680
SGTC_1798 st045719 60.953 µM 1.57596661497338 0.048773734066358 no 183 0.0575167486586616 81 3980186
SGTC_496 calpeptin 138 µM 1.57509342210977 0.0488665334669926 no 184 0.0576174410809146 74 73364 A calpain inhibitor.
SGTC_272 doxorubicin 8.13 µM 1.57294262508304 0.0490957132878763 no 185 0.057866052011038 88 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.56904015718687 0.0495137351528775 no 186 0.0583192911327414 79 2374 Ca(2+)-ATPase inhibitor.
SGTC_3027 9089541 49.47 µM 1.56888981591829 0.0495298959574966 no 187 0.0583368076405117 91 9943819
SGTC_327 1273-0057 3.96 µM 1.55921295198368 0.0505789884038762 no 188 0.0594729931629241 84 3108138
SGTC_2357 9067248 200 µM 1.55680706029702 0.0508425455082943 no 189 0.0597581502180059 85 9150235
SGTC_862 0452-0056 10.2 µM 1.55666243131739 0.0508584238885367 no 190 0.0597753263652921 62 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1403 3909-7815 62.9 µM 1.55136563098983 0.0514426685349213 no 191 0.0604070433733618 84 6615483
SGTC_23 0213-0011 39.996 µM 1.5498213726176 0.0516140037070774 no 192 0.0605921978635199 95 627608
SGTC_978 1416-0512 87.4 µM 1.54867608646851 0.0517413657629364 no 193 0.0607298026247636 93 6814003
SGTC_1332 1480-0653 17.5 µM 1.54342167341591 0.0523288902727151 no 194 0.0613642491978718 94 5749438
SGTC_2286 7945697 125 µM 1.54303893128675 0.0523718928986375 no 195 0.061410665143807 87 1245733
SGTC_289 k017-0060 526 µM 1.5426840391547 0.0524117915295708 no 196 0.0614537281620194 82 5512909
SGTC_602 3130-1533 38.1 µM 1.53764954035121 0.0529803965777675 no 197 0.0620671637719985 116 720941
SGTC_2054 5233173 129 µM 1.53524733688166 0.053253424252536 no 198 0.0623615423440732 43 6889
SGTC_2729 fluphenazine 10.66 µM 1.53330617205537 0.0534748653512408 no 199 0.0626002172972082 99 3372 An atypical antipsychotic.
SGTC_3249 9135183 49.47 µM 1.53298335871977 0.0535117613903286 no 200 0.0626399776114272 86 4902779
SGTC_1742 st038235 28.8875 µM 1.53144015596326 0.0536884209362727 no 201 0.0628303230299185 103 564103 YBR002C RER2
SGTC_1664 st014217 9.02 µM 1.52678389968265 0.0542242508285874 no 202 0.0634073782187518 92 3982782
SGTC_839 0122-0028 230 µM 1.51932687659098 0.0550911910381146 no 203 0.0643401189089201 155 759448
SGTC_2101 5377231 179.231 µM 1.51930500111186 0.0550937502570126 no 204 0.0643428707422103 105 2844213
SGTC_196 k015-0023 18.111 µM 1.51573614194293 0.0555125312945492 no 205 0.0647930424482206 66 5211998
SGTC_2308 7584454 197.62 µM 1.51424298268174 0.0556884871828881 no 206 0.0649821118899132 108 893577
SGTC_3272 9137413 49.47 µM 1.51379902632637 0.0557408883974802 no 207 0.0650384098293768 97 17614870
SGTC_38 0929-0051 58.268 µM 1.51013093432085 0.0561753320996184 no 208 0.0655050087532486 91 1379719
SGTC_1061 3448-9325 110 µM 1.51003770673796 0.0561864085368707 no 209 0.0655169014889844 108 723482
SGTC_1655 st012546 55.1 µM 1.50369206535628 0.0569443948897123 no 210 0.0663303366061872 81 720985 YLR208W SEC13
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.50262574402616 0.0570725534401672 no 211 0.0664677904493663 94 94937 An inhibitor of serotonin biosynthesis.
SGTC_3337 9144342 33.5465 µM 1.50261267761738 0.0570741252669127 no 212 0.066469476137624 105 17682949
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.50223876772203 0.0571191192889296 no 213 0.0665177280178247 107 1377
SGTC_3251 9135047 49.47 µM 1.50205259705829 0.0571415323335787 no 214 0.0665417628577934 73 17682963
SGTC_3028 9087778 49.47 µM 1.50106212318103 0.0572608916702805 no 215 0.0666697471779602 89 17217395
SGTC_2847 9005661 71.43 µM 1.49547860967503 0.0579374203440927 no 216 0.0673947891575947 56 2991449
SGTC_3233 9132340 49.47 µM 1.49284790140811 0.0582583409678243 no 217 0.0677385026010553 128 17682950
SGTC_1081 sertraline 6 µM 1.48789059263587 0.0588668774157481 no 218 0.0683898745031279 97 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_456 gingerol 170 µM 1.48156615496089 0.059650464209902 no 219 0.0692278850671203 91 442793 A herb.
SGTC_2854 9024559 71.43 µM 1.48095226144205 0.0597269576856167 no 220 0.069309647555047 87 3163529
SGTC_2248 tofa 1.1 µM 1.47751717258198 0.0601564019557489 no 221 0.0697685292585565 118 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_10 0279-0212 42.575 µM 1.47214510604814 0.0608328430301943 no 222 0.0704908486257762 92 39851 YBR002C RER2
SGTC_2119 5528445 120.635 µM 1.47187771186331 0.0608666675950037 no 223 0.070526951648491 98 791935
SGTC_1374 2889-5571 141 µM 1.47156760462775 0.0609059136476192 no 224 0.0705688394997542 148 2853281
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.46736044407861 0.061440313822563 no 225 0.0711390144862779 113 616764
SGTC_1654 st012436 41.8 µM 1.46557996406089 0.0616675732346616 no 226 0.0713813764844918 64 4323132
SGTC_1283 0922-0125 16.4 µM 1.46498171787221 0.0617440801631367 no 227 0.0714629528733963 95 3360884
SGTC_575 k072-0246 11.9 µM 1.46364241923683 0.0619156254708158 no 228 0.0716458379547315 104 6796779
SGTC_1400 3771-8998 51.5 µM 1.46243531070428 0.0620705575875353 no 229 0.0718109795587701 71 670767
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.45908084318177 0.0625026912040307 no 230 0.0722714290853037 120 5393153
SGTC_256 clotrimazole 625 nM 1.45893651726153 0.0625213362434041 no 231 0.072291290569333 104 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2113 5491891 107.031 µM 1.4554465070152 0.0629735218232637 no 232 0.0727728445992034 102 789979
SGTC_151 3013-0144 2.285 µM 1.45462941265834 0.063079756376716 no 233 0.0728859418805981 124 906558 YHR107C CDC12
SGTC_2347 9049783 174.81 µM 1.45341912103907 0.0632373689121292 no 234 0.0730537103495257 104 6467988 YPL169C MEX67
SGTC_968 1309-0633 340 µM 1.45100975264243 0.0635520461389737 no 235 0.0733885722688692 105 3761976
SGTC_801 0866-0028 10.1 µM 1.449892681852 0.063698354770428 no 236 0.0735442242040844 105 6849771
SGTC_365 0121-0052 13.6 µM 1.44965421961096 0.0637296213372633 no 237 0.0735774840526104 95 3101739
SGTC_1353 1498-1206 8.11 µM 1.44891014289553 0.0638272595499648 no 238 0.0736813391063929 97 6756808
SGTC_2441 5730946 39.09 µM 1.44692982751117 0.0640876846950011 no 239 0.0739582890830569 100 1774275
SGTC_475 α-linolenic acid 10 µM 1.44381973046662 0.0644983504527895 no 240 0.0743948452263769 119 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1783 st039459 87.517 µM 1.43595259888471 0.0655462742754502 no 241 0.0755079149019882 111 729761
SGTC_2451 5856223 45.7 µM 1.43555588566761 0.0655994652082138 no 242 0.0755643775880462 128 2179896
SGTC_203 k066-0004 30.888 µM 1.43522281650312 0.0656441486467333 no 243 0.0756118068958958 136 6795412
SGTC_552 k242-0005 476 µM 1.4317626334772 0.0661097522230167 no 244 0.0761058822583216 113 4088318
SGTC_3069 9117009 49.47 µM 1.43137909057411 0.0661615190168054 no 245 0.0761607988431084 78 41904981
SGTC_1763 st044482 94.5 µM 1.42790053838546 0.0666324541037397 no 246 0.0766602443226065 117 88505
SGTC_2481 5478948 45.16 µM 1.42717402448325 0.066731138093149 no 247 0.0767648698702742 101 77792
SGTC_2941 9056145 11.23 µM 1.4269080536893 0.0667672937615731 no 248 0.0768031995648783 99 2119517
SGTC_1821 st053465 65.6 µM 1.42627847284141 0.066852938437763 no 249 0.0768939879710072 81 675086
SGTC_24 0417-1663 219 µM 1.42085617539111 0.0675940797690936 no 250 0.0776792878447911 84 4329390
SGTC_2445 5742597 35.57 µM 1.41975143818896 0.0677458552261075 no 251 0.0778400285960125 131 1774255
SGTC_114 0364-0001 490.298 µM 1.41448110318295 0.0684735516988792 no 252 0.0786103459510624 110 4003655
SGTC_2275 7947463 200 µM 1.41332306647989 0.0686342516570228 no 253 0.0787803773845328 109 1225414
SGTC_1317 1273-0028 910 nM 1.41188052887148 0.0688348382630146 no 254 0.0789925709077057 125 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_302 1094-0063 18.9 µM 1.41006379902852 0.069088099415637 no 255 0.0792604226839142 133 5440289
SGTC_2366 9070441 60.58 µM 1.40996263359988 0.0691022234569237 no 256 0.0792753583181385 99 6837235
SGTC_1347 1493-0251 600 nM 1.40826369378916 0.0693397506710013 no 257 0.0795265010238014 103 3986378
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.40744144998757 0.0694549334308696 no 258 0.0796482637165474 71 6708630 An antioxidant.
SGTC_2330 7979373 200 µM 1.40468495544859 0.069842147922602 no 259 0.0800574906975887 113 1863007
SGTC_21 0849-0113 22.993 µM 1.40268173577088 0.0701245880908971 no 260 0.0803558830280117 100 1560156
SGTC_1076 itraconazole 331 nM 1.40265101551552 0.0701289262652143 no 261 0.0803604655394967 116 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3277 9138724 49.47 µM 1.40003749314246 0.0704987523700808 no 262 0.080751045627904 89 15943418
SGTC_1900 st060200 72.8 µM 1.4000257958151 0.0705004109622324 no 263 0.0807527969614944 122 688945
SGTC_3007 9078383 71.4286 µM 1.39649069382388 0.0710030372702591 no 264 0.0812833905373322 118 6496995
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.39568853393419 0.0711174718079433 no 265 0.0814041543092231 89 364106
SGTC_2348 9022543 33.42 µM 1.3941433286635 0.0713383068227324 no 266 0.081637163611099 155 3162678 YDL140C RPO21
SGTC_2665 lovastatin 100 µM 1.39410964167184 0.0713431270989661 no 267 0.0816422490375842 109 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_229 benomyl 22.8748 µM 1.38723202209342 0.0723324922876895 no 268 0.0826855119596684 108 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.38670610609847 0.0724085773673055 no 269 0.0827656989574743 87 688667
SGTC_1797 st048695 56.8 µM 1.38224388791183 0.0730566026256427 no 270 0.0834484142958247 114 592262 YIL048W NEO1
SGTC_454 lyso-paf C-16 6.67 µM 1.38062967948355 0.073292115984203 no 271 0.0836964264490615 103 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2266 7929956 200 µM 1.3764999711458 0.0738972847203689 no 272 0.0843334481235735 120 2967153
SGTC_383 2324-0395 7.37 µM 1.37609151103881 0.0739573474981445 no 273 0.0843966516907203 90 3146421
SGTC_2681 menadione 3.18 µM 1.37534781927863 0.0740668008152234 no 274 0.0845118189887826 121 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_96 0929-0093 37.281 µM 1.3721702051278 0.0745358626228283 no 275 0.0850052291782429 127 6991579
SGTC_2083 5306046 65.942 µM 1.36883329536839 0.0750308760543747 no 276 0.0855256952939955 111 539837
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.36695773880363 0.0753102037589752 no 277 0.0858192761970535 123 5282362
SGTC_2068 5226020 147 µM 1.36578344083518 0.0754854957227687 no 278 0.0860034726738531 118 1810509
SGTC_459 nigericin 15.3 µM 1.36470472631835 0.0756467934142071 no 279 0.0861729367821284 117 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1388 3346-4487 254 µM 1.36452667837147 0.0756734417407543 no 280 0.0862009317937776 118 3345614
SGTC_1340 1486-1359 257 µM 1.36173348407458 0.0760924340823384 no 281 0.0866410049889639 123 4309068
SGTC_20 0481-0013 4.944 µM 1.35896481943377 0.0765094873822441 no 282 0.0870788684963912 141 182045
SGTC_1008 4106-0037 6 µM 1.35833075025202 0.0766052436183346 no 283 0.0871793785388327 136 2905394
SGTC_2184 6075246 200 µM 1.35669233964683 0.076853096130436 no 284 0.0874394937548667 101 2267320
SGTC_2430 5571206 200 µM 1.35283893210479 0.0774384275005219 no 285 0.0880535460718076 131 1731771
SGTC_492 tmb-8 126 µM 1.3512496804188 0.0776808180963639 no 286 0.0883077325585955 97 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3094 9117742 49.47 µM 1.34980635209694 0.0779014513308999 no 287 0.088539053392238 139 17149698
SGTC_3153 9100258 49.47 µM 1.34851311696811 0.0780995443330068 no 288 0.0887467020983715 111 25236848
SGTC_2617 dihydrotanshinone i 20.83 µM 1.34842493231498 0.0781130660379743 no 289 0.0887608746917915 139 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_658 3253-0951 102 µM 1.34809970898004 0.0781629491825764 no 290 0.0888131575186357 128 1184878
SGTC_269 exalamide 29 µM 1.34600397771518 0.0784849746507318 no 291 0.08915061688443 129 3316 A derivative of salicylamide.
SGTC_87 0100-0052 35.5 µM 1.34539132257459 0.0785793036242015 no 292 0.0892494480106427 139 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2737 bleomycin 30.5 nM 1.34196051098077 0.0791091256816874 no 293 0.0898043999452058 129 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2144 5628481 200 µM 1.3418628102573 0.0791242531748415 no 294 0.0898202410317449 82 2818399
SGTC_746 1095-0025 46.6 µM 1.34110968235202 0.0792409372792545 no 295 0.0899424220725122 119 6749286
SGTC_706 4262-0057 46.9 µM 1.34018584631654 0.0793842475065901 no 296 0.0900924659677567 107 883298
SGTC_315 k915-0449 187 µM 1.33786094523192 0.0797457661626497 no 297 0.0904708851735049 108 20970215 YNL149C PGA2
SGTC_1899 st063254 59.6 µM 1.33761615859907 0.0797839024668752 no 298 0.0905107971402332 119 3093813
SGTC_217 ketoconazole 989 nM 1.33423278986809 0.0803124251322135 no 299 0.0910637882354687 125 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1640 st009078 66.4 µM 1.33135198624141 0.0807645229521603 no 300 0.0915366100157744 123 690618
SGTC_1914 st062367 72.6 µM 1.32940450331529 0.081071237357527 no 301 0.0918572764579758 132 978205
SGTC_855 0428-0020 25 µM 1.32010132025232 0.0825485606366286 no 302 0.093400596021329 114 6812414
SGTC_2035 5154463 94.595 µM 1.32002403583067 0.0825609175274202 no 303 0.0934134965866557 146 2769623
SGTC_202 3594-0513 34.79 µM 1.31835462709182 0.0828281767858333 no 304 0.0936924810520731 120 708429
SGTC_594 1487-1584 10.8 µM 1.31803399978035 0.0828795811372499 no 305 0.0937461332679748 135 5013332
SGTC_2808 7946468 45.46 µM 1.31463034117598 0.0834267509056977 no 306 0.0943170839422647 141 2970879
SGTC_2717 st081029 62.2815 µM 1.313701778829 0.08357649629365 no 307 0.0944732910597559 112 5292846
SGTC_2205 7238770 200 µM 1.31357764583063 0.0835965300007996 no 308 0.0944941877415102 109 279867
SGTC_1407 3909-7909 12.3 µM 1.31186259960421 0.083873689115734 no 309 0.094783249339883 116 4411780
SGTC_865 0488-0499 301 µM 1.30636014073562 0.0847675701058804 no 310 0.0957150569959964 112 9634651
SGTC_1987 st072290 61.9 µM 1.30082294119852 0.0856742869793423 no 311 0.0966595337367085 120 54697379
SGTC_3116 9124943 49.47 µM 1.2964976473489 0.0863875905799367 no 312 0.0974020450305675 113 41905195 YPL160W CDC60
SGTC_1607 st000305 50.6 µM 1.29574216655409 0.0865126345549241 no 313 0.097532164423643 120 5457690
SGTC_3001 9076041 71.4286 µM 1.29115492615579 0.0872748016854865 no 314 0.0983249806006237 106 16004211
SGTC_2940 9060638 45.86 µM 1.29063559570149 0.0873614030338721 no 315 0.0984150334380867 119 4027022
SGTC_3248 9135562 49.47 µM 1.28975281160739 0.0875087595457968 no 316 0.0985682483522445 125 17650701
SGTC_485 niflumic acid 177 µM 1.2897262492868 0.0875131962671699 no 317 0.0985728611803044 104 4488 A COX2 inhibitor.
SGTC_768 0384-0033 77.3 µM 1.28916804688967 0.0876064720061903 no 318 0.0986698354921437 130 3965305 YMR134W ERG29
SGTC_1240 0356-0016 42.1 µM 1.28865690192393 0.0876919494856527 no 319 0.0987586959305269 118 4305613
SGTC_2455 5377712 9.75 µM 1.28702551407031 0.0879651785509238 no 320 0.0990426976881007 121 2243908
SGTC_562 3772-2733 112 µM 1.28400216130788 0.0884732150988809 no 321 0.0995705995942727 121 2876874 YIL048W NEO1
SGTC_2586 curcumin 80 µM 1.28178577722796 0.0888470370948098 no 322 0.0999589024087457 133 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3148 9097893 49.47 µM 1.27958633045823 0.089219163721643 no 323 0.100345329940207 119 17174100
SGTC_3201 9113999 49.47 µM 1.27494933309223 0.0900074997557624 no 324 0.101163588023253 119 16649224
SGTC_2834 9001755 58.44 µM 1.27481240862037 0.090030856712978 no 325 0.101187823809791 131 2989575
SGTC_1230 0170-0365 3.77 µM 1.27466814168698 0.0900554710397301 no 326 0.101213363797528 147 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_529 4076-0302 30.3 µM 1.27414170829409 0.0901453317018514 no 327 0.101306599650096 122 5816522
SGTC_1561 5-methoxyflavone 52.9 µM 1.27315923055998 0.0903132159531131 no 328 0.101480772189503 120 94525
SGTC_2520 obtusaquinone 4.71 µM 1.26944347079486 0.0909502591254047 no 329 0.102141470094558 140 5967872
SGTC_484 loperamide 105 µM 1.26650649811623 0.0914561382992059 no 330 0.102665902231518 77 3955 An opioid-receptor agonist.
SGTC_2994 9053520 71.4286 µM 1.26562832417456 0.0916078037389506 no 331 0.102823090276384 107 4647384
SGTC_1729 st035615 45.989 µM 1.26504651675516 0.0917083876492615 no 332 0.102927326695502 135 17385451
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.26471691985787 0.0917654052453135 no 333 0.102986411216217 149 165506
SGTC_2158 5657123 3.6195 µM 1.26303838764042 0.0920561851913561 no 334 0.1032876921564 138 2858827
SGTC_2412 st077135 33.4 µM 1.2607288407149 0.0924573931164616 no 335 0.103703279630194 126 13258915
SGTC_1130 3454-2858 15.9 µM 1.257666770446 0.0929913200916629 no 336 0.104256147292065 160 715628 YIL048W NEO1
SGTC_1443 4112-3303 14 µM 1.25312080321971 0.0937881897869041 no 337 0.105080873100607 145 704433
SGTC_1877 wortmannin 25 µM 1.24963170388221 0.0944032102857115 no 338 0.105717058101085 137 312145 A covalent inhibitor of PI 3-kinase.
SGTC_429 1112-0049 25.5 µM 1.2494088283498 0.0944425971763746 no 339 0.105757790527183 130 2836170
SGTC_765 1319-0117 244 µM 1.24733260670546 0.0948100924457372 no 340 0.106137783152925 127 3487746 YGL099W LSG1
SGTC_109 0132-0036 33.701 µM 1.24591652114218 0.0950613460947515 no 341 0.106397522030639 123 67274 A color developer.
SGTC_3139 9095020 49.47 µM 1.24551835463905 0.0951320803546577 no 342 0.106470636462262 96 25236292
SGTC_1176 0848-0131 83.3 µM 1.24427889777183 0.0953525179367164 no 343 0.106698467378767 133 6769040
SGTC_2283 7944793 200 µM 1.24224041706862 0.0957158794431206 no 344 0.107073935784862 132 2970533
SGTC_3213 9129884 49.47 µM 1.23928385429281 0.0962446988726351 no 345 0.107620197926166 132 17190742
SGTC_1483 3453-0561 55.9 µM 1.23743809611362 0.0965759235773217 no 346 0.107962241452645 147 4546991
SGTC_1787 fluconazole 80 µM 1.23421686816848 0.0971559834974594 no 347 0.108561051736926 130 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2246 7293507 91.5585 µM 1.23304266195829 0.0973680623148726 no 348 0.108779923922219 148 887656
SGTC_1903 st060211 78.3 µM 1.23138932922681 0.0976672538577424 no 349 0.109088643010178 134 688960
SGTC_3132 9126706 49.47 µM 1.23080635656473 0.0977729107446377 no 350 0.109197648780347 155 850858
SGTC_2087 5276107 200 µM 1.23073047406052 0.0977866697101611 no 351 0.109211843246308 126 144405
SGTC_1475 4092-1048 11.7 µM 1.23063430121092 0.0978041097470374 no 352 0.109229835098269 142 2881759
SGTC_2249 haloperidol 116.36 µM 1.22903490022659 0.0980944803267128 no 353 0.109529360552249 170 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2870 9038528 12.99 µM 1.22808481751668 0.0982672662107567 no 354 0.109707564891714 124 6463316
SGTC_384 k007-0144 5.16 µM 1.22770273515573 0.0983368160691071 no 355 0.109779289657532 153 6824886
SGTC_3032 9089427 49.47 µM 1.22747111177099 0.0983789956612801 no 356 0.109822786543631 117 17173707
SGTC_790 1575-0012 79.1 µM 1.2268835360637 0.0984860550996484 no 357 0.109933183711824 145 378741 YLR208W SEC13
SGTC_1458 k015-0034 6.33 µM 1.22194523474865 0.0993892128513466 no 358 0.110864168900529 120 3598957
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.21907321157924 0.0999172490772073 no 359 0.111408203175669 137 6708739 YPR165W RHO1
SGTC_1723 st034307 2.5525 µM 1.21865789736005 0.0999937759784725 no 360 0.111487032119645 160 867466
SGTC_784 4579-0127 173 µM 1.21865490866849 0.0999943268377868 no 361 0.111487599534508 142 1948547
SGTC_2057 5236571 38.335 µM 1.21854144448528 0.100015241575759 no 362 0.111509142685136 131 54684039 YBR257W POP4
SGTC_2971 9092186 9.93 µM 1.21844199144441 0.100033576280913 no 363 0.111528028026186 128 25236400
SGTC_1054 3429-0080 167 µM 1.2154398590396 0.100588191357037 no 364 0.112099186755833 147 1162877
SGTC_2661 dactinomycin 12.96 µM 1.21522171212947 0.100628579145905 no 365 0.112140770766902 122 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_349 k015-0014 24 µM 1.2135057369067 0.10094668789344 no 366 0.112468261165803 145 2196908
SGTC_660 4031-1742 102 µM 1.2124276279593 0.101146923153798 no 367 0.112674365231397 148 6738706
SGTC_2707 st078556 66.6 µM 1.21117138738592 0.101380607443551 no 368 0.112914863127671 125 17250899
SGTC_3168 9103419 49.47 µM 1.20920420137537 0.101747330656154 no 369 0.113292202008711 126 16649256
SGTC_616 4092-0450 108 µM 1.20653491734378 0.102246482042677 no 370 0.113805652047561 144 787165
SGTC_1750 st081859 2.357 µM 1.20058492488424 0.103365525152821 no 371 0.114956125826079 175 5291695
SGTC_1139 k015-0024 46.9 µM 1.19874158150384 0.10371400873441 no 372 0.115314222083151 134 2766652
SGTC_386 1509-0011 3.07 µM 1.1980510292076 0.103844776687516 no 373 0.115448575844307 134 3107280
SGTC_1606 st000094 49.2 µM 1.1958093717231 0.104270097228851 no 374 0.115885478941366 143 1242210
SGTC_2860 9025725 38.96 µM 1.19232110322233 0.104934452033076 no 375 0.116567681450171 147 40546248
SGTC_1525 8-methoxypsoralen 92.5 µM 1.191983138868 0.104998981171956 no 376 0.116633928342684 152 4114 Related to psoralen; DNA damaging agent.
SGTC_3071 9117417 49.47 µM 1.18880146426406 0.105607881909828 no 377 0.117258900855369 141 45595590 YGL055W OLE1
SGTC_3238 9133470 49.47 µM 1.18702844939763 0.105948302802741 no 378 0.117608199488714 118 3534688
SGTC_2424 5537928 59.2 µM 1.18569710696946 0.106204442864006 no 379 0.117870968728777 145 5382802
SGTC_331 k048-0133 24.5 µM 1.18171752007648 0.106972750976931 no 380 0.11865890209577 142 6813582
SGTC_1287 0971-0001 34.6 µM 1.18158394564492 0.106998608526137 no 381 0.118685413396961 150 4665869
SGTC_935 2996-0153 430 µM 1.17787718657061 0.107717968189698 no 382 0.11942278560482 151 23738523
SGTC_1889 st059080 5.18 µM 1.17358536847876 0.108555213134446 no 383 0.120280572299983 124 176925 Isolated from Daphnopsis sellowiana.
SGTC_1615 st002656 86.5 µM 1.17064352106618 0.109131804390702 no 384 0.120871048010125 134 1584458
SGTC_786 4544-0069 423 µM 1.16846230738495 0.109560732781043 no 385 0.121310167369565 157 748821 YLR208W SEC13
SGTC_2913 7966556 36.57 µM 1.16838943867219 0.109575083037015 no 386 0.121324856551838 144 2976516
SGTC_2044 5102272 200 µM 1.16815949423527 0.109620375539494 no 387 0.121371217921138 148 592666
SGTC_2591 skatole 100 µM 1.16618958043147 0.110008943350405 no 388 0.121768902188126 152 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1891 st059073 26.2 µM 1.16386336027277 0.110469064336102 no 389 0.122239695038357 168 688754
SGTC_578 3460-0051 92 µM 1.1606639000803 0.111104161610568 no 390 0.12288930402842 186 2876744
SGTC_2866 9034245 58.44 µM 1.16063589121097 0.111109732930991 no 391 0.12289500153478 118 6462273
SGTC_338 4055-0136 114 µM 1.15829435499652 0.11157620196149 no 392 0.123371967126948 130 2900563
SGTC_2129 girgensonine 121.053 µM 1.15446813005777 0.112341455845904 no 393 0.124154148637179 180 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2268 7933382 153.85 µM 1.15259103961988 0.11271824648784 no 394 0.124539141378871 145 935025 YOR257W CDC31
SGTC_1734 st037168 69.4 µM 1.14874743745381 0.113492591164514 no 395 0.125330069496205 141 708907
SGTC_478 N-arachidonylglycine 10 µM 1.14859688888143 0.113522998182027 no 396 0.125361120258855 97 5283389
SGTC_2109 5483026 200 µM 1.14725270939061 0.11379474605938 no 397 0.125638596380224 205 759335
SGTC_1809 st050081 57.6 µM 1.14546244705337 0.114157396359997 no 398 0.126008821445556 156 5036894
SGTC_1419 3993-2473 62.6 µM 1.14211183042979 0.114838335298095 no 399 0.126703769274328 151 704026
SGTC_2651 TUB2.036 5 µM 1.1377672526771 0.115725570396857 no 400 0.127608841253961 167 15992207 YFL037W TUB2
SGTC_3261 9137475 49.47 µM 1.13738895589821 0.115803054687425 no 401 0.127687861058688 90 17027690
SGTC_522 1273-0010 11.6 µM 1.13640281739392 0.116005212782141 no 402 0.127894008606874 168 5705015
SGTC_2532 xanthone 78.9 µM 1.1348907401667 0.116315674528462 no 403 0.128210550096845 127 7020 An insecticide.
SGTC_2620 irigenin 100 µM 1.13427104152603 0.116443082053248 no 404 0.128340436191173 168 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_207 4185-0010 4.486 µM 1.12883820993216 0.117564289574846 no 405 0.129483045308057 161 3761753
SGTC_2946 9065502 71.43 µM 1.12847291282394 0.117639951515268 no 406 0.12956012507329 110 16489101
SGTC_2289 7946404 165.07 µM 1.12828317635376 0.117679264163567 no 407 0.129600173086791 172 1246120 YPR165W RHO1
SGTC_1460 k062-0059 9.15 µM 1.12752923483494 0.117835569754321 no 408 0.129759393592955 145 1373085
SGTC_322 k048-0136 19.3 µM 1.12703187235132 0.117938762297646 no 409 0.129864502797176 160 6823282
SGTC_93 0109-0045 59.227 µM 1.12470611162257 0.118422158525928 no 410 0.130356795514363 157 88733
SGTC_3236 9132701 49.47 µM 1.12281460414461 0.118816329029349 no 411 0.1307581207791 159 24282524
SGTC_387 norethindrone acetate 66.7 µM 1.12256969304651 0.118867433642571 no 412 0.130810146483769 149 541197
SGTC_2886 9058944 51.95 µM 1.12064740227827 0.119269089488949 no 413 0.131218989599246 97 4949929
SGTC_502 l-744,832 89.3 µM 1.11710099888475 0.120012609595604 no 414 0.131975571735033 147 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_246 cycloheximide 667 µM 1.11671792397314 0.120093118123255 no 415 0.132057475802834 162 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2999 9069765 71.4286 µM 1.1158743298012 0.120270545364826 no 416 0.132237965643658 143 2097066
SGTC_135 0933-0004 26.348 µM 1.10875194713975 0.121775909711746 no 417 0.133768602694953 164 21230617 YGL099W LSG1
SGTC_2186 6124449 200 µM 1.10734505214903 0.122074825608099 no 418 0.134072386465631 160 3834182 YLR033W RSC58
SGTC_48 0382-0018 55 µM 1.1044844368203 0.122684194121029 no 419 0.134691525502271 124 762596
SGTC_3195 9113082 49.47 µM 1.100767378621 0.123479185250048 no 420 0.135498956397367 150 17018038
SGTC_3061 glucosamine 200 µM 1.09999525773263 0.12364477531603 no 421 0.135667094062347 144 91431 and experimental redox chemotherapeutic
SGTC_2461 5755302 26.15 µM 1.09828099382496 0.124012974310133 no 422 0.136040904284645 170 2788904
SGTC_2502 avocadyne acetate 18.59 µM 1.09700206981033 0.12428816788379 no 423 0.136320243649572 143 3952079
SGTC_1698 5-fluorocytosine 1.055 µM 1.0959207518174 0.124521174410844 no 424 0.1365567283712 164 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2968 9090663 33.37 µM 1.0956571322449 0.12457802643513 no 425 0.136614424600151 200 25236811
SGTC_662 k832-1615 104 µM 1.09516684348153 0.1246838100386 no 426 0.136721774360056 157 5878478
SGTC_473 2-arachidonoylglycerol 10 µM 1.09114504196935 0.125553914810014 no 427 0.137604533032613 173 5282280 An endocannabinoid.
SGTC_646 4092-0839 27.3 µM 1.09093677383448 0.125599088107722 no 428 0.137650352208697 173 877796
SGTC_2919 7978188 46.38 µM 1.08903694387136 0.126011684269087 no 429 0.138068797220141 152 2980291
SGTC_547 1120-0019 610 nM 1.08811061930035 0.126213201450002 no 430 0.138273138128057 163 3676939
SGTC_3084 9116877 49.47 µM 1.08487727970875 0.126918357824271 no 431 0.138988006053249 133 27241325
SGTC_1445 4239-0156 97.7 µM 1.08393882883922 0.127123536320672 no 432 0.139195961022821 171 4008346
SGTC_3045 9092950 49.47 µM 1.08389306779523 0.127133547199027 no 433 0.139206106801616 150 44120432
SGTC_2320 7373003 200 µM 1.08353929699552 0.127210958099141 no 434 0.13928455906505 162 5415828
SGTC_2915 7971052 15.16 µM 1.08223180214823 0.127497344130818 no 435 0.139574770335752 128 5741558
SGTC_482 fipronil 114 µM 1.07885355612445 0.128239370002974 no 436 0.140326507864177 139 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_232 clozapine 119 µM 1.0782771395761 0.128366277790466 no 437 0.140455047902466 159 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_142 0335-0849 62.6745 µM 1.07632967064897 0.128795690614449 no 438 0.140889921757756 182 3889043 YPR107C YTH1
SGTC_2002 4023503 131 µM 1.07503647855655 0.129081386737 no 439 0.141179198371215 190 4736863 YCR052W RSC6
SGTC_318 1488-0629 67.2 µM 1.07501943083144 0.12908515590695 no 440 0.141183014496883 155 3662576
SGTC_3346 9158254 43.5805 µM 1.07128888278201 0.129911798152891 no 441 0.142019778491226 193 17639500
SGTC_2311 7694451 200 µM 1.07128530003415 0.129912593802 no 442 0.142020583713852 203 2163142
SGTC_665 3914-0008 307 µM 1.0687146565845 0.130484346677095 no 443 0.14259913259878 167 1069549
SGTC_47 0149-0135 24.25 µM 1.06805446614987 0.130631464186912 no 444 0.142747971871123 175 5239155
SGTC_163 TUB2.036 7.546 µM 1.06774800258007 0.130699795801106 no 445 0.142817099454642 204 15992207 YJR013W GPI14
SGTC_769 0302-0231 76 µM 1.06648035343728 0.130982703651287 no 446 0.143103277609815 196 571869 YER009W NTF2
SGTC_2032 5185112 25.99 µM 1.06497145989854 0.131320002476492 no 447 0.143444422583946 154 5718189
SGTC_3287 9117173 37.0625 µM 1.06068404475795 0.132281684908977 no 448 0.14441675666432 132 2789709
SGTC_3062 9077494 49.47 µM 1.06008962902928 0.132415396664242 no 449 0.144551912750051 154 16459633
SGTC_3034 9090421 49.47 µM 1.05343183440836 0.133919409448519 no 450 0.146071560177113 147 17173761
SGTC_3269 9137823 49.47 µM 1.04908832794906 0.134906923153573 no 451 0.147068733810973 133 17682936
SGTC_828 2074-0507 139 µM 1.04705414167285 0.135371116872487 no 452 0.1475373040346 170 X828
SGTC_2625 euphol 100 µM 1.04453118516749 0.135948365417798 no 453 0.148119849394481 185 6708538 A triterpene alcohol.
SGTC_2863 9028737 58.44 µM 1.04449775838004 0.135956024710178 no 454 0.148127577886978 168 6460917
SGTC_791 1348-1292 225 µM 1.04346212572423 0.136193472186405 no 455 0.148367156641503 173 5437054
SGTC_2698 st077697 67.5 µM 1.04252314805531 0.136409003999395 no 456 0.148584599554453 166 3154499
SGTC_1309 pyrazolanthrone 13.4 µM 1.04194442306563 0.136541960003957 no 457 0.148718723350722 189 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2796 7949634 45.45 µM 1.04028064017223 0.136924690236724 no 458 0.149104767973129 181 2971588
SGTC_2593 nobiletin 86.24 µM 1.03626289929024 0.137851936651616 no 459 0.150039754799127 158 72344 An anti-infammatory.
SGTC_2179 6298986 200 µM 1.03594894214051 0.137924574230402 no 460 0.150112981508636 177 738374
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.03542096923702 0.138046785665357 no 461 0.150236178516891 171 23847180
SGTC_1926 methyl fluorone black 53.6 µM 1.03211522193371 0.13881365529371 no 462 0.151009071890001 171 72721 Reacts with homocysteine.
SGTC_2676 harmalol 100 µM 1.03111670580029 0.139045861208585 no 463 0.151243047301647 177 5459187 A monoamine oxidase inhibitor
SGTC_3095 9117207 49.47 µM 1.03028965671043 0.139238392390053 no 464 0.151437026513295 131 17015229
SGTC_1769 st044406 64.4 µM 1.02643427632448 0.140138290947141 no 465 0.152343464202325 223 670903
SGTC_1757 st041620 31.8375 µM 1.02641751253314 0.14014221245322 no 466 0.152347413381254 161 5289815
SGTC_1835 st008666 49.2 µM 1.02506407307505 0.140459064686332 no 467 0.152666478036071 146 690455
SGTC_213 1246-0773 967 nM 1.02435925284899 0.140624261827391 no 468 0.15283281027767 156 6251622
SGTC_2536 dehydroabietamide 32.04 µM 1.02064799468189 0.141496288583706 no 469 0.153710620909703 151 3983547
SGTC_1216 1165-0504 9.65 µM 1.01993662211095 0.141663855941048 no 470 0.153879259781057 179 6304004
SGTC_1097 itavastatin 7.23 µM 1.01852581772194 0.141996575467089 no 471 0.154214068921535 192 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_364 0083-0097 67.7 µM 1.01624474074493 0.142535655625414 no 472 0.154756427865218 167 5207356
SGTC_817 1391-0715 46 µM 1.01414358017238 0.143033439803523 no 473 0.155257122801178 196 1353946
SGTC_380 3970-0968 6 µM 1.01094142181153 0.143794317062304 no 474 0.156022233607811 179 2891601
SGTC_1004 4084-0029 199 µM 1.00942951617924 0.14415451418984 no 475 0.156384344417879 155 716894 YLR208W SEC13
SGTC_409 arachidonic acid 100 µM 1.00916945790143 0.144216531865287 no 476 0.156446685740534 176 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_164 4100-3994 89.624 µM 1.00546640771101 0.145101572296487 no 477 0.157336158516928 202 4615967
SGTC_1313 1220-0047 237 µM 1.00475779424399 0.145271348904444 no 478 0.157506745698788 192 3528706
SGTC_1239 0337-0584 35.4 µM 1.00369476175929 0.14552629126664 no 479 0.157762881351057 198 914301 YML130C ERO1
SGTC_298 1391-0729 10 µM 0.999622473875116 0.146505712714877 no 480 0.158746621444976 184 3237558
SGTC_287 k060-0039 29.6 µM 0.997429591064304 0.147034949169542 no 481 0.159278016993599 182 5861974
SGTC_1958 st076513 41.9 µM 0.997307325704513 0.147064494716734 no 482 0.159307679484317 189 732122 YGL099W LSG1
SGTC_564 3555-0129 330 µM 0.996407724337763 0.147282006688407 no 483 0.159526040721645 186 563260
SGTC_1530 rhein 70.4 µM 0.995640964404418 0.147467569449263 no 484 0.159712311791454 199 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2055 5235184 200 µM 0.995052875441035 0.147609998337717 no 485 0.159855274233951 183 2836034
SGTC_3024 9090631 49.47 µM 0.993231877005481 0.148051609015738 no 486 0.160298483549342 166 25236383
SGTC_1562 morin hydrate 59.1 µM 0.990819994202916 0.148637875000904 no 487 0.160886742181522 175 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_136 0097-0015 404.482 µM 0.990568080111316 0.14869919815822 no 488 0.160948265253105 191 4861337
SGTC_527 4476-4215 268 µM 0.989003195926783 0.149080514898309 no 489 0.161330789008463 159 4418754
SGTC_936 3005-4620 401 µM 0.988809990047393 0.149127638806516 no 490 0.161378057772372 184 777207
SGTC_119 0121-0043 24.815 µM 0.987601677477481 0.149422578113595 no 491 0.161673882213887 202 1092378
SGTC_3319 9138450 16.7555 µM 0.98636178360742 0.149725630668248 no 492 0.161977805725497 176 2029690
SGTC_1186 1319-0216 26 µM 0.985314218572379 0.149981993918099 no 493 0.162234875339325 191 4565136
SGTC_2368 9071271 200 µM 0.985030045313509 0.150051588087176 no 494 0.162304656461727 184 27209959
SGTC_2666 tannic acid 100 µM 0.983896971810991 0.15032929237746 no 495 0.162583086382985 207 16134267 A thiamine antagonist.
SGTC_1227 3909-8010 46.6 µM 0.983389348744647 0.150453816418286 no 496 0.162707925233519 162 15982272
SGTC_700 3453-2283 142 µM 0.983245634217281 0.150489083231104 no 497 0.162743280017156 183 565664
SGTC_663 1486-0733 13.9 µM 0.976857341836917 0.15206230090072 no 498 0.164319891542064 190 722445 YPR165W RHO1
SGTC_1279 0874-0590 65.2 µM 0.969860554656098 0.153797859255767 no 499 0.166058002049656 184 3523074
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.968326946143726 0.154180017080472 no 500 0.166440555680424 175 6708514
SGTC_2263 7948595 193.29 µM 0.966176954654124 0.154716827131198 no 501 0.16697782121463 178 2971371
SGTC_1215 3852-0577 11.2 µM 0.963505737168905 0.15538549521432 no 502 0.167646893209043 184 2884876
SGTC_2474 5321570 43.32 µM 0.963074206885266 0.155493695969902 no 503 0.167755142343539 190 2841384
SGTC_19 0279-0214 38.434 µM 0.962282453831549 0.155692347261863 no 504 0.16795387017815 203 3566274 YBR002C RER2
SGTC_2012 4023501 200 µM 0.961820624072914 0.155808297863614 no 505 0.168069858118094 216 3477460
SGTC_3202 9113761 49.47 µM 0.959772155822462 0.156323288558525 no 506 0.168584949435259 195 4798415
SGTC_410 α-linolenic acid 100 µM 0.958896576912215 0.156543753213934 no 507 0.168805424704355 200 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2207 7258803 200 µM 0.956215581580216 0.157220081573125 no 508 0.169481664686728 201 3666799
SGTC_3222 9128301 49.47 µM 0.952674959072635 0.15811620581096 no 509 0.170377392308796 199 4911358
SGTC_4 0960-0234 25.671 µM 0.948675469600544 0.159132492932815 no 510 0.171392846957629 195 6821112
SGTC_2204 7233102 200 µM 0.947010878311366 0.159556730877739 no 511 0.171816617872529 178 2172480
SGTC_505 gw-5074 63.9 µM 0.945673674484401 0.159898066506726 no 512 0.172157526887506 203 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.942762001269142 0.160642953342396 no 513 0.172901325970622 197 688751
SGTC_2477 5967686 25.23 µM 0.942722029020688 0.160653195098213 no 514 0.172911551276722 191 776118
SGTC_1591 genipin 88.4 µM 0.942571226243493 0.160691837875221 no 515 0.172950131623895 192 442424 A DNA cross-linking agent.
SGTC_2416 tofa 880 nM 0.941622244178477 0.160935151070367 no 516 0.173193038521606 165 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_614 0462-0418 107 µM 0.940448145239784 0.161236515495706 no 517 0.173493868158186 186 5188303
SGTC_416 estradiol valerate 100 µM 0.93875202924322 0.161672519421675 no 518 0.173929036739382 220 13791 A steroid.
SGTC_899 1083-0020 478 µM 0.937541266659231 0.161984227939052 no 519 0.174240103504421 221 767123
SGTC_2588 indole-3-carbinol 100 µM 0.93661821001027 0.162222129926883 no 520 0.174477490772937 199 3712 Induces cell cycle arrest.
SGTC_3334 9142812 21.919 µM 0.933514546948266 0.163023713242446 no 521 0.17527718159143 182 45283678
SGTC_175 3793-3120 23.7 µM 0.932955250006365 0.163168436242696 no 522 0.175421536990974 215 5322297
SGTC_41 0478-0632 82.643 µM 0.932450250913903 0.163299180901831 no 523 0.175551942759702 207 3750424
SGTC_1676 st018489 23.4 µM 0.93190911473908 0.16343935700292 no 524 0.175691748367403 197 3696235
SGTC_506 n9-isopropylolomoucine 153 µM 0.930022417330406 0.163928698816696 no 525 0.176179738895001 179 6610355
SGTC_343 4130-2827 29.8 µM 0.928392346446426 0.164352245592194 no 526 0.17660204357851 177 1118244
SGTC_417 st075190 100 µM 0.928330668129174 0.164368285594174 no 527 0.176618035223051 212 222757
SGTC_43 0570-0105 72.5 µM 0.927828520249748 0.164498911437498 no 528 0.176748263678223 190 1114046 YDL195W SEC31
SGTC_49 0717-0965 32.132 µM 0.927542934510058 0.164573232065341 no 529 0.176822355366728 208 5889349 YGL099W LSG1
SGTC_2910 7948405 25.97 µM 0.927100763933929 0.164688345138887 no 530 0.176937109777478 181 2971328
SGTC_3262 9137218 49.47 µM 0.926333602181444 0.164888188968291 no 531 0.177136319223455 155 17650664
SGTC_2086 5274770 176.623 µM 0.925982941559768 0.164979587512759 no 532 0.177227422681261 200 689278
SGTC_1412 3909-8563 178 µM 0.925922155376421 0.164995434568285 no 533 0.177243218257585 217 23767530
SGTC_1695 st026914 34.495 µM 0.923959977170236 0.165507506947886 no 534 0.177753577013005 198 3289191
SGTC_2269 7935389 174.42 µM 0.922959366899099 0.165769032948376 no 535 0.178014190376135 208 97605
SGTC_1846 st056244 14.8 µM 0.922291072059795 0.16594385155185 no 536 0.178188384837388 197 5393182
SGTC_1802 st050112 57.9 µM 0.922214934288252 0.165963775915866 no 537 0.178208237351377 199 4662563
SGTC_3117 9124945 49.47 µM 0.920616512703382 0.166382421032192 no 538 0.178625338975408 173 17592065
SGTC_1364 1653-0028 37.6 µM 0.920499044670778 0.166413214143784 no 539 0.178656016012228 190 5718652
SGTC_275 trichlorophene 5.69 µM 0.917936408796173 0.167085900049109 no 540 0.179326079493509 198 62616
SGTC_89 0302-0250 142.109 µM 0.915714693704744 0.167670511960139 no 541 0.179908278094648 220 4203518 YLR208W SEC13
SGTC_507 nimesulide 162 µM 0.915333778283473 0.167770876430251 no 542 0.180008215746647 193 4495 A COX2 inhibitor.
SGTC_2640 pentamidine 10.38 µM 0.914571681978561 0.167971791406013 no 543 0.180208265308631 210 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2749 bexarotene 57.39 µM 0.914145434341372 0.168084232546315 no 544 0.180320215736438 214 82146 An retinoic acid receptor inhibitor.
SGTC_2131 toluylene red 5.2905 µM 0.912380213553037 0.168550400910842 no 545 0.180784300867044 175 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1767 st044992 70.3 µM 0.910465684842903 0.169056937933241 no 546 0.181288485386819 217 9600693
SGTC_2377 9073351 62.6 µM 0.910190926651969 0.169129712303909 no 547 0.181360914190363 212 7337946 YHR072W ERG7
SGTC_1712 st032288 53.4 µM 0.910125674290068 0.169146998455149 no 548 0.181378117979257 216 2883011
SGTC_2777 climbazole 1.536 µM 0.910084164104521 0.169157995602952 no 549 0.18138906267374 219 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_926 2268-1401 59.4 µM 0.909188717015246 0.169395335020817 no 550 0.181625259476773 231 2931578
SGTC_3318 9139014 38.6185 µM 0.907623505109179 0.16981070948782 no 551 0.182038585678001 235 16643984
SGTC_1206 3978-0017 132 µM 0.907059014344311 0.169960673634148 no 552 0.182187795185252 199 3873677
SGTC_1181 1222-0449 220 µM 0.905806409853008 0.17029374705113 no 553 0.182519163861157 203 658318
SGTC_2721 ifenprodil 61.44 µM 0.90563244110103 0.170340039207681 no 554 0.182565215959325 207 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_3091 9116372 49.47 µM 0.904877454876353 0.170541030400244 no 555 0.182765156036134 201 17169793
SGTC_1779 st039427 55 µM 0.904448839959907 0.170655203106123 no 556 0.182878725270506 203 1124498
SGTC_3289 9119912 71.43 µM 0.904408386032769 0.170665981585882 no 557 0.182889446540667 214 17014829
SGTC_1324 1418-0026 34.4 µM 0.904037565786526 0.170764802644944 no 558 0.182987741161566 198 1372513
SGTC_2462 5162487 171.77 µM 0.903979720205705 0.170780221397835 no 559 0.183003077463813 201 2259986
SGTC_1939 st074455 53.6 µM 0.903963175006136 0.170784631688453 no 560 0.183007464155238 196 1644229
SGTC_1238 0333-0287 48.8 µM 0.902208218549399 0.171252846990507 no 561 0.183473134924117 209 7226
SGTC_115 0527-0192 112.043 µM 0.900429019390238 0.17172836712577 no 562 0.183945991654521 245 4233931
SGTC_588 3970-1144 52.9 µM 0.900394333252019 0.171737645938298 no 563 0.18395521770453 176 1888707
SGTC_2711 st079103 59.1 µM 0.899854259364305 0.171882161225189 no 564 0.184098907323485 195 54693780
SGTC_633 0437-0093 97.7 µM 0.899027779072023 0.172103464660923 no 565 0.184318932165895 204 2831118
SGTC_620 0109-0052 432 µM 0.898992193916181 0.172112997242639 no 566 0.184328409286809 226 493037
SGTC_2036 5160441 105 µM 0.896491151774721 0.172783822608061 no 567 0.184995251956931 229 134534 YIL048W NEO1
SGTC_218 alverine citrate 93.75 µM 0.893049788965083 0.173709579359515 no 568 0.185915255120401 208 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1722 st034304 3.6505 µM 0.892896942850841 0.173750769357837 no 569 0.185956182217992 196 4036148 YLR033W RSC58
SGTC_3263 9137018 49.47 µM 0.891164331578446 0.174218119405839 no 570 0.186420508299777 221 43844957
SGTC_251 melphalan 456.522 µM 0.891047168072391 0.174249751595645 no 571 0.186451933093327 227 460612 A DNA alkylator.
SGTC_368 fentichlor 4.58 µM 0.890506948072129 0.174395649178519 no 572 0.186596869641114 214 7329 A pesticide.
SGTC_1521 st012942 49.4 µM 0.89033533564312 0.174442012901176 no 573 0.186642926430004 203 24207259
SGTC_2225 6654152 15.4 µM 0.889689058840718 0.174616684718833 no 574 0.186816435262571 213 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2265 7929201 200 µM 0.889385078312771 0.174698881143052 no 575 0.18689808078786 237 1265108
SGTC_3203 9113543 49.47 µM 0.887681052673252 0.175160104876234 no 576 0.187356170338782 208 17018012
SGTC_2505 galangin 7.89 µM 0.887345506402551 0.17525101715701 no 577 0.187446456249221 222 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1667 st014849 34.6 µM 0.887342730530764 0.175251769371308 no 578 0.187447203269109 215 5348460
SGTC_462 ag-879 158 µM 0.887200837456538 0.175290222721404 no 579 0.187485390822415 234 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1045 1348-1485 165 µM 0.887194548811849 0.17529192708241 no 580 0.187487083390868 215 6810614
SGTC_1293 1000-1278 195 µM 0.886586933125222 0.175456653851273 no 581 0.187650665728565 216 678847
SGTC_686 1319-0111 510 µM 0.884677143012007 0.175975043356995 no 582 0.188165393420463 232 4562600
SGTC_2298 7976326 193.81 µM 0.883055221819962 0.176416055052317 no 583 0.188603218021184 179 2235818
SGTC_1038 k292-0204 154 µM 0.882702611994972 0.176512024572545 no 584 0.188698485262487 203 4454212
SGTC_866 0495-0101 262 µM 0.882030451623074 0.176695057345234 no 585 0.188880170018443 199 635694
SGTC_3200 9114385 49.47 µM 0.881521826411775 0.176833638369168 no 586 0.189017722882141 199 17018030 YLR208W SEC13
SGTC_3353 9151644 39.2805 µM 0.879750278086577 0.177316854064879 no 587 0.189497302878066 199 4909158
SGTC_1247 0448-0043 5.84 µM 0.879706646817864 0.177328765641894 no 588 0.189509123840685 215 3089013 YGL099W LSG1
SGTC_1430 4049-0248 69.1 µM 0.87936831862442 0.177421148253261 no 589 0.189600802055867 232 22774488
SGTC_556 4058-0063 51.5 µM 0.879111600213057 0.177491267077917 no 590 0.189670384327823 208 6615692
SGTC_1520 flindersine 88 µM 0.878436119793212 0.177675848081025 no 591 0.189853545023279 221 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1514 1189-1591 158 µM 0.878134244353079 0.177758377361698 no 592 0.189935435566582 232 767698 YMR146C TIF34
SGTC_308 4092-1169 104 µM 0.878126238491706 0.177760566401449 no 593 0.189937607633153 219 2268590 YDL196W YDL196W
SGTC_1990 st072050 59.8 µM 0.877129292811818 0.178033293803977 no 594 0.190208207843934 224 17233948
SGTC_987 1497-1013 404 µM 0.87572310982143 0.178418421601475 no 595 0.190590289451458 209 1676435
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.874442156429678 0.178769707773193 no 596 0.190938754021315 235 5282309
SGTC_1799 st045822 46.1415 µM 0.873893501731884 0.17892030286874 no 597 0.19108812694835 226 3674992
SGTC_1726 st035556 14.5795 µM 0.872406315419211 0.179328908086882 no 598 0.191493378219137 179 5919439
SGTC_2142 5622915 118.518 µM 0.870546208843722 0.179840798533607 no 599 0.192000989042434 209 5322196
SGTC_1922 5578187 25 µM 0.870536061565785 0.17984359351982 no 600 0.192003760424173 205 1350412
SGTC_624 k048-0052 28 µM 0.869683275363606 0.180078584124703 no 601 0.192236757269873 193 6835531
SGTC_3205 9113483 49.47 µM 0.869564096898136 0.180111439846503 no 602 0.192269332782783 210 17018033
SGTC_1504 k297-0033 30 µM 0.86880428728111 0.180320996468592 no 603 0.19247709386556 155 4388117
SGTC_1017 4239-0030 168 µM 0.868613859151698 0.180373540797351 no 604 0.192529185719876 223 1149593
SGTC_1700 st030840 7.9285 µM 0.864499600057687 0.181511122453971 no 605 0.193656749970912 237 5499307
SGTC_1985 st071382 65.5 µM 0.86362497885212 0.181753530442338 no 606 0.193896968854676 221 6123237
SGTC_606 k015-0008 38.6 µM 0.863383940548186 0.181820371643522 no 607 0.193963203081349 237 1970475
SGTC_1278 0874-0585 172 µM 0.862425949552385 0.182086179600824 no 608 0.194226582951667 219 766306
SGTC_112 phenothiazine 287.218 µM 0.861157644104163 0.182438462134991 no 609 0.19457561225932 217 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_734 2023-0417 80 µM 0.857503132312272 0.183455912399556 no 610 0.195583442229263 235 3935732
SGTC_1398 3558-0053 112 µM 0.854743630859637 0.184226522454806 no 611 0.196346545270078 200 4532369
SGTC_991 3996-0057 64.7 µM 0.854068840184365 0.184415268561724 no 612 0.196533423828576 208 715343
SGTC_1744 st037937 38.9 µM 0.853613630808687 0.184542663374005 no 613 0.196659551734214 224 1016152
SGTC_1169 aniline yellow 25.8 µM 0.852754282520823 0.184783309574211 no 614 0.196897790722814 235 6051 A DNA damaging agent.
SGTC_8 0354-0001 70 µM 0.852087021596855 0.184970299370706 no 615 0.197082897371335 221 4993152
SGTC_1954 st077032 68.9 µM 0.850962235351498 0.18528576975802 no 616 0.197395165638278 244 698907
SGTC_3302 9125395 16.351 µM 0.85071257969264 0.185355836313713 no 617 0.197464516732363 210 17599668
SGTC_3323 9138564 53.9225 µM 0.85058869008408 0.185390612383441 no 618 0.19749893712269 222 43912313 YNL103W MET4
SGTC_1007 4101-0031 70 µM 0.849640903607541 0.18565679201546 no 619 0.197762381726505 240 1146276
SGTC_292 k038-0015 474 µM 0.849472389795047 0.185704142832769 no 620 0.197809243671474 229 46368540
SGTC_1144 3486-0183 12.5 µM 0.849197033498428 0.185781531518094 no 621 0.197885831841219 236 6744069
SGTC_3348 9149464 3.537 µM 0.848560006091232 0.185960644261641 no 622 0.198063084607412 199 1951442
SGTC_421 streptovitacin 30 mM 0.84807239333067 0.18609781846859 no 623 0.198198827533022 216 91467 include heat shock
SGTC_2004 4023728 41.89 µM 0.847315448264779 0.186310884897611 no 624 0.198409659120471 256 360084 YDR527W RBA50
SGTC_565 1418-0001 44.5 µM 0.846600642822147 0.186512228475114 no 625 0.198608877756031 225 2862145
SGTC_931 2812-0076 566 µM 0.846364778425062 0.186578695385815 no 626 0.198674640404697 225 3450959
SGTC_1694 st024011 44.9 µM 0.845942125695495 0.186697836189244 no 627 0.198792515376771 236 2787533
SGTC_972 1319-0219 195 µM 0.845889800507044 0.186712589316319 no 628 0.198807111448434 239 23903702
SGTC_1499 4480-0877 67.3 µM 0.845120122151185 0.18692968409648 no 629 0.199021887281619 211 2861909
SGTC_263 alizarin 107.927 µM 0.844405109923099 0.18713149967808 no 630 0.199221533954125 240 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1426 4048-4480 71.7 µM 0.843895545257899 0.187275408922891 no 631 0.199363888868947 212 14224343
SGTC_1357 1503-1303 39.5 µM 0.841696113783289 0.187897348439208 no 632 0.19997903705308 211 292895
SGTC_1872 amphotericin b 148 nM 0.840800784228303 0.188150888161292 no 633 0.200229773869512 217 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3283 9109332 35.8195 µM 0.840639683882312 0.18819653101344 no 634 0.200274910027222 195 17027281
SGTC_1638 st008370 60.6 µM 0.839747760450043 0.188449353827566 no 635 0.200524914548371 225 24207134
SGTC_3349 9149703 23.001 µM 0.839340213846422 0.188564945854965 no 636 0.200639211477358 202 4910494
SGTC_2006 4011487 200 µM 0.838912825781747 0.188686212446179 no 637 0.200759114973867 224 45595294
SGTC_2954 9074818 52.69 µM 0.834458019716515 0.189953074189818 no 638 0.202011467118091 234 16648742
SGTC_428 3448-4153 16.5 µM 0.831556765406204 0.19078094021127 no 639 0.202829587215906 220 3834874
SGTC_2771 fluoxetine 41.05 µM 0.831060891818141 0.190922657783048 no 640 0.202969615623138 230 3386 A selective serotonin reuptake inhibitor.
SGTC_1829 berberine 14.4 µM 0.830854307878598 0.190981717232543 no 641 0.203027969337692 232 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_858 0438-0351 2.77 µM 0.830080403910141 0.191203065119612 no 642 0.203246662844781 240 2799119
SGTC_2409 alverine citrate 63.97 µM 0.827557072984489 0.191925866515496 no 643 0.203960693743368 187 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.827195933650703 0.192029450553358 no 644 0.204063008035987 241 165521
SGTC_290 2043-6722 48.1 µM 0.825725218702106 0.192451642626373 no 645 0.204479991604665 226 773758 YLR208W SEC13
SGTC_3031 9088762 49.47 µM 0.822965877951958 0.193245284914997 no 646 0.205263698933146 234 205253
SGTC_1479 0549-0158 134 µM 0.822602300831788 0.193350005796007 no 647 0.205367094911849 220 5440202
SGTC_165 k038-0023 64.381 µM 0.822303633993238 0.193436056511976 no 648 0.205452054501163 216 46368543
SGTC_1342 1486-1464 234 µM 0.821270027537798 0.193734035438725 no 649 0.205746238092663 241 3253938
SGTC_1827 berberine 7.24 µM 0.819327626456139 0.194294767824985 no 650 0.206299757320574 209 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1805 st050013 60.3 µM 0.817623940678468 0.19478740051246 no 651 0.206785976452171 232 4037144
SGTC_72 0744-0168 198.391 µM 0.817131053868046 0.194930063764401 no 652 0.206926769072671 243 677577
SGTC_1678 st019265 80.2 µM 0.815919376234208 0.195281046869122 no 653 0.207273124635478 229 5367020
SGTC_921 1561-0023 372 µM 0.815302514008432 0.195459878948385 no 654 0.207449585047477 235 24050882
SGTC_2612 dictamnine 15.46 µM 0.814049968323885 0.195823305398716 no 655 0.207808162994852 228 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1211 1056-0033 32.3 µM 0.81235348183906 0.196316194738536 no 656 0.208294415244296 227 6741922
SGTC_2148 5546263 113.568 µM 0.811473468217785 0.196572165802734 no 657 0.208546911670863 223 792097
SGTC_834 0312-0008 75.7 µM 0.811272468108437 0.19663065940269 no 658 0.208604608595423 224 6385573 YIL048W NEO1
SGTC_822 1487-0950 154 µM 0.811248799250373 0.196637548036656 no 659 0.208611403341904 215 1958375
SGTC_2127 5253358 187.912 µM 0.811155741837948 0.196664633077917 no 660 0.208638119099017 212 20612
SGTC_2466 5983409 37.09 µM 0.809350408649417 0.197190535599983 no 661 0.209156809327598 220 2879657
SGTC_3210 9128157 49.47 µM 0.80903614728189 0.197282168368244 no 662 0.209247177271816 210 17590849
SGTC_608 k048-0125 159 µM 0.807900811954665 0.197613425586109 no 663 0.20957384193037 235 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2196 6573537 42.6665 µM 0.804439449690317 0.198625421675934 no 664 0.210571612800293 247 2903087
SGTC_1456 k015-0012 13 µM 0.804435375429474 0.198626614703437 no 665 0.210572788885185 244 2989616
SGTC_2561 acetosyringone 100 µM 0.80420872934224 0.198692988153445 no 666 0.210638219102998 264 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2914 7968218 45.32 µM 0.803736115144866 0.198831436535325 no 667 0.210774695958152 197 2977111
SGTC_2747 doxorubicin 7.63 µM 0.802156557829433 0.199294576460902 no 668 0.211231201083235 190 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1133 3473-0247 50 µM 0.801687553213208 0.19943221767293 no 669 0.211366858753639 233 711311
SGTC_3100 9120536 49.47 µM 0.801206078210785 0.199573578147281 no 670 0.211506176501198 221 16421196
SGTC_2873 9040596 71.43 µM 0.800449576244208 0.199795807971328 no 671 0.211725183565549 254 6463863
SGTC_2450 5739737 12.93 µM 0.800251983196586 0.199853877361897 no 672 0.211782408537834 242 2262825
SGTC_407 eburnamonine 100 µM 0.799576856018865 0.200052362864028 no 673 0.211978000566821 222 3195
SGTC_1420 4'-methoxyflavone 42 µM 0.798970747915471 0.200230657865237 no 674 0.21215368695401 235 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2598 perillyl alcohol 100 µM 0.798605511456431 0.200338143265482 no 675 0.212259595421151 218 10819 An apoptosis inducer.
SGTC_310 1273-0058 1.06 µM 0.793538947924946 0.201832754617301 no 676 0.213731943355686 205 2734232
SGTC_2689 tacrolimus 100 µM 0.793462223947154 0.201855439009837 no 677 0.213754285039303 232 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1303 1160-0052 261 µM 0.790554231351724 0.202716347882493 no 678 0.214602081947035 236 3562476
SGTC_872 0588-0139 234 µM 0.788561059467234 0.203307690102067 no 679 0.215184299003431 219 2047100
SGTC_990 3985-0011 41.3 µM 0.787800759141439 0.203533529999244 no 680 0.21540662847893 235 5399565 YGL099W LSG1
SGTC_2545 solidagenone 89.61 µM 0.786714106662983 0.203856569291651 no 681 0.215724622138534 197 6708572 An anti ulcer agent
SGTC_2095 5432005 200 µM 0.785745151269609 0.204144877241632 no 682 0.216008402769721 256 783734
SGTC_2128 5255449 168.493 µM 0.78501441059604 0.204362466116081 no 683 0.216222559771501 231 736008
SGTC_2183 6420625 130.508 µM 0.784391465017404 0.204548066373984 no 684 0.21640522246946 248 2897619
SGTC_1020 4335-0961 93.3 µM 0.78264921923507 0.20506768294932 no 685 0.216916564956223 248 669075
SGTC_61 0978-8327 98.565 µM 0.782178949461804 0.205208073035813 no 686 0.217054706947606 232 6150059 YHR072W ERG7
SGTC_1319 1306-0155 43.7 µM 0.78192231348166 0.205284710900579 no 687 0.217130115336833 256 3122360
SGTC_2738 aclarubicin 5.55 µM 0.781595752249878 0.20538225475791 no 688 0.217226092026247 205 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_154 3389-1638 511.116 µM 0.781507373073786 0.205408658354942 no 689 0.217252070971745 241 5238686
SGTC_943 3253-1379 105 µM 0.781024517649488 0.205552948741118 no 690 0.217394037385191 241 668464
SGTC_3354 9151612 71.43 µM 0.780837911960006 0.205608727734357 no 691 0.217448916478574 227 27261949
SGTC_2576 guaiol 23.12 µM 0.780470160681977 0.205718679920438 no 692 0.217557092306226 231 227829
SGTC_3253 9135987 49.47 µM 0.779567288374206 0.205988773329038 no 693 0.217822808283233 242 4182430
SGTC_2522 biochanin a 4.94 µM 0.778555364886113 0.206291739118705 no 694 0.218120840448268 227 5280373 A possible chelator.
SGTC_1751 st044839 27.194 µM 0.776042163610852 0.207045322935576 no 695 0.218862045497132 236 5291326
SGTC_716 1683-5115 658 µM 0.775660200736243 0.207159996978131 no 696 0.218974822489843 260 723597
SGTC_546 peri-Naphthalide 147 µM 0.773447057336607 0.207825172635798 no 697 0.21962892485426 237 223824 A penicillin ester.
SGTC_2013 4024628 200 µM 0.773399316153566 0.207839535465582 no 698 0.219643047282026 259 5230760
SGTC_425 3825-7017 13.1 µM 0.773218784447178 0.207893853331245 no 699 0.219696455490111 245 3397440
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.772147835366542 0.208216249756857 no 700 0.220013436613487 223 4174840
SGTC_563 tetrahydrosecaminediol 614 µM 0.769511960391864 0.209011003915226 no 701 0.220794723526147 237 334274 A psychoactive constituent of the cannabis plant.
SGTC_3327 9140648 26.9345 µM 0.769027308442372 0.209157327649903 no 702 0.220938549575819 265 8029710
SGTC_2969 9091408 28.7 µM 0.768884937662104 0.209200322994249 no 703 0.220980809934095 230 4286311
SGTC_3344 9148862 3.898 µM 0.767299276164204 0.209679537317182 no 704 0.221451799353457 255 4905352
SGTC_1885 st057546 99.9 µM 0.767159062056098 0.209721943486689 no 705 0.221493474784247 227 702008
SGTC_2136 5328288 199.296 µM 0.765490209940983 0.210227055986477 no 706 0.221989846964066 240 262395
SGTC_745 0469-0705 296 µM 0.763927076157425 0.210700818038433 no 707 0.222455350499215 271 3486736
SGTC_683 panaxydol 45 µM 0.763177696784896 0.21092816544851 no 708 0.222678714045013 219 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2906 7926292 26.41 µM 0.762241430041164 0.211212412936526 no 709 0.222957961669445 259 2966319
SGTC_2959 9079155 11 µM 0.761898831512337 0.211316480781789 no 710 0.223060193728133 251 16189457
SGTC_3295 9122362 53.5725 µM 0.761798361423926 0.211347005304895 no 711 0.223090179256577 264 4730473
SGTC_1558 st069300 45.6 µM 0.761793018889135 0.211348628530224 no 712 0.223091773812613 244 24208000
SGTC_1461 k072-0203 53.8 µM 0.759613059283168 0.212011576074029 no 713 0.223742955343594 252 5418714
SGTC_1707 st032323 6.317 µM 0.758654773000631 0.212303384913243 no 714 0.224029549138984 247 3132057 YMR211W DML1
SGTC_2506 ethyl hematommate 54.16 µM 0.756474836096893 0.212968073632281 no 715 0.224682277057103 240 3940691 An allergen.
SGTC_1067 clotrimazole 1.36 µM 0.754622129026189 0.213533939463584 no 716 0.225237871039859 240 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2303 7774051 200 µM 0.749454232360992 0.215116974896176 no 717 0.226791737075221 270 2953184
SGTC_1574 spiramycin 23.7 µM 0.748505963319222 0.21540818765555 no 718 0.227077514741594 270 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2670 beta-carotene 100 µM 0.748285405413861 0.215475953603077 no 719 0.227144012862185 220 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_497 capsazepine 133 µM 0.747061331427806 0.215852272421495 no 720 0.227513270133638 250 2733484 A calcium channel blocker.
SGTC_2813 7971799 71.43 µM 0.745659020452565 0.216283854637522 no 721 0.227936710005818 240 2234054
SGTC_1810 st050138 53 µM 0.745171437146928 0.216434032672826 no 722 0.228084043795372 277 3444541
SGTC_1570 verbenone 133 µM 0.74479846967713 0.216548949196299 no 723 0.228196780085685 252 29025 A natural terpanoid with antifungal properties.
SGTC_13 0199-0087 65 µM 0.743750811849066 0.216871936092451 no 724 0.22851362150291 249 4589825
SGTC_2684 capsaicin 100 µM 0.743302811867489 0.217010136879778 no 725 0.228649184789959 266 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_336 4111-0029 111 µM 0.743193985698608 0.217043715683878 no 726 0.228682122038891 255 3131175
SGTC_1645 Cervolide 78 µM 0.742760039886592 0.217177641469422 no 727 0.228813486251149 261 23173 A fragrance.
SGTC_2864 9034755 47.6 µM 0.741256788820073 0.217641948724213 no 728 0.229268878257474 248 4930451
SGTC_355 1311-2252 105 µM 0.740843427673199 0.217769723395277 no 729 0.229394190115012 263 5338538
SGTC_2202 7226349 200 µM 0.740829961027662 0.217773886817566 no 730 0.229398273220672 229 844334
SGTC_105 0111-0055 734.78 µM 0.740675174936345 0.217821744634747 no 731 0.229445207503737 241 5179370
SGTC_1107 amlodipine 47 µM 0.737754267074713 0.218725987460485 no 732 0.230331894341443 232 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_92 0063-0024 660.874 µM 0.735550900522633 0.219409523931281 no 733 0.231002026255947 255 3594437
SGTC_1437 4092-1038 11.6 µM 0.735055679770091 0.219563321888213 no 734 0.231152792355419 270 3977136
SGTC_3328 9140624 29.0385 µM 0.73497846500059 0.219587307628713 no 735 0.231176304737321 254 4904392
SGTC_728 3030-5151 22.5 µM 0.734973800218521 0.219588756729381 no 736 0.23117772523548 258 3125388
SGTC_2874 9043904 71.43 µM 0.734278811460868 0.219804714274756 no 737 0.231389414448405 259 4463428
SGTC_1637 st007924 17.4 µM 0.734132253836731 0.219850270463377 no 738 0.231434068778188 246 683336
SGTC_3250 9135583 49.47 µM 0.732078601246184 0.220489200629279 no 739 0.232060296977145 250 7699353
SGTC_1326 1431-2094 10.8 µM 0.731765260571491 0.220586780318674 no 740 0.232155928033504 268 616278
SGTC_301 4119-0100 24.5 µM 0.72891574260473 0.221475304181031 no 741 0.233026602194521 275 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1961 st076550 68.7 µM 0.727855112018724 0.221806547023897 no 742 0.233351141833309 276 1579337
SGTC_3127 9126946 49.47 µM 0.726775745980496 0.222143931431938 no 743 0.233681671600846 239 27243249
SGTC_3254 9136651 49.47 µM 0.726246345600019 0.222309516526406 no 744 0.233843882497526 278 16454030
SGTC_938 3126-1755 342 µM 0.723960242580654 0.223025368617104 no 745 0.234545071787204 253 1777771
SGTC_346 4513-0042 7.16 µM 0.722715758086602 0.223415607751953 no 746 0.234927266105847 247 2827372
SGTC_1937 st074714 47.2 µM 0.721741536705487 0.22372137006457 no 747 0.235226699770724 238 17250970
SGTC_2995 9067767 71.4286 µM 0.720644622839633 0.224065924343435 no 748 0.235564095884828 240 11673567
SGTC_626 0214-0009 33 µM 0.719566309092053 0.224404929707692 no 749 0.235896030915005 270 3437874
SGTC_1200 1643-0193 18.4 µM 0.719095800385434 0.224552941628914 no 750 0.236040947361183 277 5403974
SGTC_2828 7998861 71.43 µM 0.717146833324632 0.22516663431348 no 751 0.236641750350552 210 2988188
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.716476504392145 0.22537792753875 no 752 0.236848585171711 275 91467 include heat shock
SGTC_2983 9022671 12.99 µM 0.71528361384885 0.22575421401044 no 753 0.237216905853693 259 6405161
SGTC_797 k781-0471 270 µM 0.71471359661392 0.225934146165849 no 754 0.237393017219382 263 23738129
SGTC_2323 6148992 148.28 µM 0.714011069788445 0.226156017927744 no 755 0.23761016720036 270 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_871 0574-0004 149 µM 0.713214511654266 0.22640773550317 no 756 0.237856513916788 273 9551173
SGTC_2753 fluvastatin 17.09 µM 0.71148336747266 0.226955333591519 no 757 0.238392377031241 278 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2185 6113692 200 µM 0.711322431678997 0.227006278959308 no 758 0.238442227101799 280 874150
SGTC_3124 9127567 49.47 µM 0.710813570782511 0.227167404910638 no 759 0.238599884971195 240 17592030
SGTC_813 k007-0158 173 µM 0.710656070931786 0.227217288797612 no 760 0.238648693935169 266 6523916
SGTC_2725 haloperidol 53.21 µM 0.709285287216294 0.227651708664829 no 761 0.239073728355967 266 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_687 k029-0044 34.9 µM 0.707440598410748 0.228237052787537 no 762 0.239646357471861 255 5829338
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.707003735438318 0.228375798984753 no 763 0.239782078219396 261 803109
SGTC_40 0327-0103 19.753 µM 0.705899842318033 0.228726602807776 no 764 0.24012521281842 258 409036
SGTC_1053 3366-3204 134 µM 0.705739496464586 0.228777583925029 no 765 0.24017507704432 283 3632071 YPR165W RHO1
SGTC_2511 berberine 10.47 µM 0.704900521299969 0.229044435631038 no 766 0.240436072866299 277 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2861 9024595 19.48 µM 0.704874692419102 0.229052653758292 no 767 0.240444110393525 239 16482810
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.704390517090696 0.229206737286461 no 768 0.240594804952192 249 6312947
SGTC_479 n-linoleoylglycine 10 µM 0.704333685532896 0.229224827122072 no 769 0.240612496557459 274 6433346 An anti-infammatory.
SGTC_1225 1216-0074 20.6 µM 0.702307176210119 0.229870400557799 no 770 0.241243809453282 270 4241466
SGTC_277 nystatin 15.5 µM 0.699617316652706 0.230728863649832 no 771 0.24208316260699 288 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2786 7743617 45.45 µM 0.698599592709898 0.231054134513507 no 772 0.242401149165592 259 583674
SGTC_2841 9004761 38.96 µM 0.697835436637173 0.231298531653136 no 773 0.242640057432409 241 2991039
SGTC_519 k048-0011 62.8 µM 0.696970909890018 0.231575203729242 no 774 0.242910499552567 263 6836379
SGTC_2600 tangeritin 87.95 µM 0.696287765023099 0.231793959081299 no 775 0.243124316910028 277 68077 A bioactive flavone.
SGTC_408 cantharidin 100 µM 0.696184716140318 0.231826967188264 no 776 0.243156578987906 251 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2760 etidronate 98.04 µM 0.696174618872375 0.231830201635887 no 777 0.243159740319371 274 3305 A chelator and antioxidant.
SGTC_925 2064-1272 59.6 µM 0.695640249205842 0.232001411593014 no 778 0.243327076649696 271 6815817
SGTC_830 4076-0286 57.8 µM 0.695396048805013 0.23207967588035 no 779 0.243403568019449 270 6866659
SGTC_1886 st057356 49.9 µM 0.694814945265873 0.232265974032029 no 780 0.243585640450915 264 24207747
SGTC_2763 lisinopril 49.32 µM 0.692710240319519 0.232941425234683 no 781 0.244245705686393 279 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1191 1487-1166 10.6 µM 0.691370340853857 0.233371999436944 no 782 0.244666418904921 286 3955771
SGTC_2757 clomiphene 4.22 µM 0.691161003463438 0.233439309479671 no 783 0.244732183696299 295 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1119 parthenolide 318.541 nM 0.690335678553938 0.233704788162165 no 784 0.244991557934819 295 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3160 9100216 49.47 µM 0.689279447266426 0.234044785517498 no 785 0.245323714575874 262 17191039
SGTC_2843 9000894 45.46 µM 0.689256292172526 0.234052242133081 no 786 0.245330998947382 216 2242070
SGTC_1596 piperlongumine 63 µM 0.688506569887807 0.234293745662435 no 787 0.245566917231752 251 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1103 duloxetine 36.1 µM 0.688242700119363 0.234378777247737 no 788 0.245649979232533 274 60835 A selective serotonin reuptake inhibitor.
SGTC_2951 9072950 58.06 µM 0.687887899291249 0.234493138127159 no 789 0.245761688661985 277 16488155
SGTC_2608 thymoquinone 42.66 µM 0.685060881090404 0.235405456443867 no 790 0.246652752027656 271 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_455 paf C-16 10 µM 0.684724221391399 0.23551423162207 no 791 0.246758980819939 264 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_740 k014-0057 261 µM 0.6828767544263 0.236111643944104 no 792 0.247342361889972 278 4012779
SGTC_3166 9102297 49.47 µM 0.682803457380989 0.236135363093263 no 793 0.247365522348716 274 25237072
SGTC_3296 9122258 64.045 µM 0.681954271825969 0.236410257820673 no 794 0.247633933167546 268 4730474
SGTC_798 1287-0182 476 µM 0.6808422529273 0.236770502062459 no 795 0.247985655527092 296 1649755
SGTC_3308 9128332 17.569 µM 0.678393773593844 0.237564762617127 no 796 0.248761027935579 254 17332805 YDL196W YDL196W
SGTC_2231 micatex 6.853 µM 0.67554629546495 0.23849029022845 no 797 0.249664374330516 281 20737 An antifungal of unknown mechanism.
SGTC_3187 9109394 49.47 µM 0.673033704044635 0.239308604912532 no 798 0.250462924471269 270 17098090
SGTC_2092 5303694 80.6725 µM 0.672652573019506 0.239432867617927 no 799 0.250584173404651 276 1963699
SGTC_1152 3909-8331 15.9 µM 0.67251503448976 0.239477718878427 no 800 0.250627936070412 281 16001939
SGTC_1789 tunicamycin 25 nM 0.672450696650081 0.239498700997483 no 801 0.250648408781012 293 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2125 5246583 200 µM 0.672235679206443 0.239568830646653 no 802 0.250716835128154 280 835267
SGTC_1070 indatraline 8.81 µM 0.671298339669145 0.239874682305445 no 803 0.251015246080791 290 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1246 0422-0085 105 µM 0.670345445127359 0.240185827716643 no 804 0.251318801647064 291 264295
SGTC_3329 9141233 27.5565 µM 0.668383091223886 0.24082728078857 no 805 0.251944543004867 286 4909101 YNL103W MET4
SGTC_1478 0453-0656 35.7 µM 0.668146274415589 0.240904754303657 no 806 0.252020113014297 294 5258496
SGTC_1301 naphtanilide LB 4.81 µM 0.665162510796869 0.241882039181195 no 807 0.252973277954176 286 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_788 1182-0090 188 µM 0.663490787988975 0.242430524448295 no 808 0.253508138712573 273 5715185
SGTC_3274 9138298 49.47 µM 0.662119027306161 0.242881096195489 no 809 0.253947471249517 287 17015756
SGTC_621 3584-0052 32.1 µM 0.661279740078519 0.243156993721617 no 810 0.254216465876728 296 2273927
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.660879122187197 0.243288747912317 no 811 0.254344918036747 269 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_299 1273-0059 1.44 µM 0.659401528752819 0.243775028509471 no 812 0.254818980350302 277 2848077
SGTC_961 1252-1571 372 µM 0.657994365660627 0.244238617559449 no 813 0.25527087582052 300 6813498
SGTC_1334 1486-0610 236 µM 0.657379489754459 0.24444133717818 no 814 0.255468468132836 268 3742339
SGTC_655 k060-0012 42 µM 0.657280254978457 0.244474062576464 no 815 0.255500365028913 298 5994525
SGTC_1249 0481-0015 10.2 µM 0.655824346138238 0.244954459824294 no 816 0.255968574869112 315 4227577
SGTC_2194 5927483 104.545 µM 0.655528141378579 0.245052258822563 no 817 0.256063886968836 252 760979
SGTC_2354 9060492 162 µM 0.655285454831594 0.24513240317024 no 818 0.256141991893478 293 6471895
SGTC_340 k038-0059 454 µM 0.65482014114205 0.245286106901719 no 819 0.256291780671752 290 23733424
SGTC_2741 miltefosine 3.04 µM 0.653773892431434 0.245631895855447 no 820 0.256628744482149 270 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_907 3448-6986 75.5 µM 0.652612499163277 0.246016046898337 no 821 0.257003062748714 297 590582
SGTC_2654 protoveratrine a 100 µM 0.651896999201882 0.246252871324557 no 822 0.257233810440599 310 5702278 A heart drug and vasodilator.
SGTC_2703 st077852 53.4 µM 0.650325083733442 0.246773590982536 no 823 0.257741128839202 297 6281836
SGTC_373 0844-0104 25.9 µM 0.649450983074 0.247063404276354 no 824 0.25802345973162 281 5375804
SGTC_749 1000-0129 128 µM 0.647711773475086 0.247640590749139 no 825 0.258585693953038 290 708470
SGTC_770 0389-1121 67.2 µM 0.646899049335884 0.247910553868246 no 826 0.258848640572245 291 6753108
SGTC_2541 muurolladie-3-one 83.07 µM 0.646020105984334 0.248202689764119 no 827 0.25913316721716 299 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_3136 9095672 49.47 µM 0.645601863300476 0.248341766232234 no 828 0.259268615162063 279 17217380
SGTC_1808 st050063 61.5 µM 0.644550971213976 0.248691398173735 no 829 0.259609108083454 304 4011993
SGTC_3093 9117344 49.47 µM 0.642745343099478 0.249292742524005 no 830 0.260194676898497 271 24824913
SGTC_2137 5261020 140 µM 0.642368791545455 0.249418246180813 no 831 0.260316879048228 286 763655
SGTC_3181 9108277 49.47 µM 0.642277882751521 0.249448550877743 no 832 0.260346386079151 308 17097298
SGTC_2739 tacrine 100.86 µM 0.640891745400567 0.249910865868347 no 833 0.260796509654304 277 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3085 9117376 49.47 µM 0.640584785650062 0.250013306872254 no 834 0.260896243523979 291 16480349
SGTC_710 3448-4187 58 µM 0.639180721620886 0.250482165983419 no 835 0.26135268598004 274 3946412
SGTC_2989 9073649 71.4286 µM 0.63832097529809 0.250769490917052 no 836 0.261632380357397 315 21367202
SGTC_2628 lathosterol 100 µM 0.636309623141644 0.251442360567453 no 837 0.262287316973025 277 6710616
SGTC_2235 salicylic acid 500 µM 0.635201927307903 0.251813331702873 no 838 0.262648363215203 284 338 A COX inhibitor and kinase inhibitor.
SGTC_2525 harmine 47.85 µM 0.633106017131927 0.252516049061041 no 839 0.263332206596489 274 5280953 A monoamine oxidase inhibitor
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.632175028016621 0.252828522450987 no 840 0.26363625655209 307 23665772 A membrane-active detergent.
SGTC_2842 9000675 19.48 µM 0.629620370718786 0.253687001729755 no 841 0.264471496221756 285 2989072
SGTC_1219 1469-0211 33.1 µM 0.628438019896243 0.254084842141992 no 842 0.264858518603542 300 6822282
SGTC_2415 st077333 57.7 µM 0.62809519723088 0.254200257158669 no 843 0.264970789570922 303 2766255
SGTC_268 camptothecin 39.6153 µM 0.626348563380566 0.254788707204962 no 844 0.265543169765607 303 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2324 6149169 200 µM 0.624767928751831 0.255321845291566 no 845 0.266061691296914 297 2888231
SGTC_2221 6807166 181.081 µM 0.623205714151796 0.255849342825639 no 846 0.266574673594516 278 674925
SGTC_169 k015-0017 16.025 µM 0.622410760719933 0.256117985079203 no 847 0.266835903252752 336 1840002
SGTC_1265 0819-1001 68.8 µM 0.621438747859601 0.256446661630814 no 848 0.267155492087379 311 3106768
SGTC_2748 diazoxide 86.69 µM 0.621306345630568 0.256491449137702 no 849 0.26719903966263 252 3019 A potassium channel activatior.
SGTC_583 1488-1091 88.9 µM 0.621249345753409 0.256510731656835 no 850 0.267217788232926 308 4303273
SGTC_1441 4106-0040 13 µM 0.621082389530659 0.256567215712377 no 851 0.267272707793922 285 2904180
SGTC_994 3910-0338 138 µM 0.619082053721832 0.257244465896424 no 852 0.26793115262188 295 3479481
SGTC_1023 4482-3888 16 µM 0.614856415794143 0.258678181843299 no 853 0.269324774081782 318 3303168
SGTC_2458 5808907 16.39 µM 0.613844759022944 0.259022039377397 no 854 0.269658958419995 312 2731747
SGTC_2387 9077560 195.08 µM 0.611711378972517 0.259747939632469 no 855 0.270364365988074 282 5303272
SGTC_2175 5807670 165.306 µM 0.611493976339261 0.259821971580434 no 856 0.270436302477254 273 241186
SGTC_1132 3456-3614 2.5 µM 0.61095937638883 0.260004064771023 no 857 0.27061323724934 302 3125502
SGTC_1833 st055984 71 µM 0.610854485806497 0.260039799881988 no 858 0.270647959321189 297 676288
SGTC_2790 5423970 71.43 µM 0.610473443919119 0.260169638126025 no 859 0.270774114854077 309 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2041 5107442 45.335 µM 0.61044275187285 0.260180097751419 no 860 0.270784277669009 300 793005
SGTC_3126 9127922 49.47 µM 0.610239097291702 0.260249507236465 no 861 0.270851717025563 332 45595682
SGTC_535 2293-4129 48.2 µM 0.610203107020145 0.260261774420614 no 862 0.270863635923918 320 396118 YIL048W NEO1
SGTC_958 1222-0007 33 µM 0.609503962076238 0.260500135133139 no 863 0.27109522367751 314 7312461
SGTC_3182 9108849 49.47 µM 0.609162617623852 0.260616551121443 no 864 0.271208327935048 284 17133045
SGTC_3294 9122953 26.2835 µM 0.608863749569571 0.260718502460986 no 865 0.27130737697906 302 16459826
SGTC_1534 6-azauridine 81.6 µM 0.608406532489189 0.260874510304092 no 866 0.271458939979614 301 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_258 haloperidol 50.781 µM 0.607510475817391 0.261180394577796 no 867 0.271756096301029 314 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_726 3448-4391 34.2 µM 0.604135501699716 0.262334151939101 no 868 0.272876779025471 312 1356692
SGTC_623 k072-0108 16.9 µM 0.603256200288994 0.262635175030963 no 869 0.273169132864695 311 5382803
SGTC_1338 1486-1223 76 µM 0.602019976264192 0.263058686970397 no 870 0.273580420151493 294 3444526
SGTC_1781 st038725 66.3 µM 0.60130864159589 0.263302537726906 no 871 0.27381721745197 299 4270275 YIL048W NEO1
SGTC_2920 7982904 15.77 µM 0.598290562729377 0.264338439708762 no 872 0.274823036250265 297 6456808
SGTC_236 1509-0011 5.31 µM 0.597751575082745 0.264523655764288 no 873 0.275002853222235 328 3107280
SGTC_3216 9129716 49.47 µM 0.597113656312942 0.264742953499593 no 874 0.275215750449023 282 8056934
SGTC_1507 4075-3230 155 µM 0.595239449145712 0.265387785214951 no 875 0.275841712117199 308 659771
SGTC_1275 0867-0008 21.1 µM 0.595187470069404 0.265405680267032 no 876 0.27585908244053 301 3422836
SGTC_2223 6903751 107.57 µM 0.591869450763883 0.266549254197602 no 877 0.276969006017283 301 5598863
SGTC_2524 avocatin b 10.57 µM 0.590562856286724 0.267000262163123 no 878 0.27740667923163 293 6710748
SGTC_66 0109-0187 42.4 µM 0.590246174230755 0.267109631909653 no 879 0.277512809895265 293 759417
SGTC_1096 rimcazole 32.2 µM 0.587213647542323 0.268158093465798 no 880 0.278530113828383 324 18528119 A dopamine reuptake inhibitor.
SGTC_731 3966-0296 387 µM 0.585692149440546 0.268684913235159 no 881 0.279041205322933 301 660956
SGTC_3186 9110464 49.47 µM 0.585439464087867 0.26877245603929 no 882 0.279126129842548 318 17018021
SGTC_1057 3448-5381 134 µM 0.584722932598457 0.269020776162471 no 883 0.27936701580668 290 5497911
SGTC_288 1315-0019 35.1 µM 0.584546794077956 0.269081836103051 no 884 0.279426246106842 317 6811474
SGTC_3270 9137563 49.47 µM 0.583782018825062 0.269347032683296 no 885 0.279683488660268 302 17015724
SGTC_1142 3253-1408 9.78 µM 0.583143016862336 0.269568716058327 no 886 0.279898513751912 314 256655
SGTC_1691 st019933 84.6 µM 0.582663113661074 0.269735264780669 no 887 0.280060054575482 338 6176082
SGTC_106 0092-0003 11.579 µM 0.58210435660271 0.269929244367202 no 888 0.280248195415049 303 1072148
SGTC_2237 6667747 47.222 µM 0.580244804009078 0.270575314032331 no 889 0.280874771757072 332 729940 YDL015C TSC13
SGTC_1071 trifluoperazine 6.31 µM 0.580032516886218 0.270649118648164 no 890 0.280946344960087 339 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2117 5521686 200 µM 0.578274598798255 0.271260669766308 no 891 0.281539370485566 308 803312
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.577447844681564 0.271548522039224 no 892 0.281818480768554 336 368090
SGTC_2389 9091542 195.52 µM 0.577203708803349 0.271633552293394 no 893 0.281900925973246 307 3626624 YOL127W RPL25
SGTC_2018 5133068 143 µM 0.577047128989861 0.271688094561897 no 894 0.281953809424642 315 785362
SGTC_1825 st052143 62.6 µM 0.576998615137431 0.271704994753011 no 895 0.281970195520203 317 674173
SGTC_1179 1021-1431 9.29 µM 0.57667447889988 0.271817923647541 no 896 0.282079687924156 329 2840958
SGTC_3026 9090633 49.47 µM 0.5756441585052 0.272177041770787 no 897 0.282427863455365 304 25236842
SGTC_2111 5486399 200 µM 0.574110133717594 0.272712162609519 no 898 0.282946638150343 297 689674
SGTC_420 mitomycin C 81.9 mM 0.571691531546097 0.273556913620941 no 899 0.283765486300833 303 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_671 0560-0003 407 µM 0.571666947510662 0.27356550679025 no 900 0.283773815357101 308 3238678
SGTC_2894 9048625 32.47 µM 0.570725751629159 0.273894595331631 no 901 0.284092779945381 340 4092861
SGTC_725 1497-0963 19 µM 0.570300323769901 0.274043410110577 no 902 0.284237010672475 316 3549977
SGTC_2697 mebhydrolin 72.4 µM 0.570195517373393 0.274080077549034 no 903 0.284272548046298 316 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1112 tnp00069 1.16933 µM 0.569628185159921 0.27427860577345 no 904 0.284464953858205 313 145826
SGTC_2198 6589944 200 µM 0.56959358232722 0.274290716741233 no 905 0.284476691122184 291 5290268
SGTC_1492 4158-0558 28.5 µM 0.569093913488881 0.274465629922666 no 906 0.284646204333015 288 3967268
SGTC_2797 7859098 81.82 µM 0.568620623402389 0.27463135975108 no 907 0.284806812982236 304 972681
SGTC_957 1187-1561 14.1 µM 0.567423333686176 0.27505082946122 no 908 0.28521330026908 303 1538454
SGTC_3150 9097574 49.47 µM 0.565599709580392 0.275690340833887 no 909 0.285832962653007 321 17217476
SGTC_763 3453-1109 128 µM 0.564938777704491 0.275922297789428 no 910 0.286057703414739 311 1560353
SGTC_2799 7812892 81.82 µM 0.564621406733317 0.276033714589639 no 911 0.286165650864604 319 20205235
SGTC_902 1120-0002 2.07 µM 0.559803954510422 0.277727645184711 no 912 0.287806583007489 309 3280475
SGTC_1967 st070177 51.4 µM 0.558668713369996 0.278127560802362 no 913 0.288193917699753 334 5729214
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.558227616558113 0.278283023350377 no 914 0.288344482515994 333 6710655
SGTC_2555 cholic acid 100 µM 0.556422822422815 0.278919555676696 no 915 0.288960920352676 310 6708657 Influences liver metabolism.
SGTC_1192 1488-0095 21.4 µM 0.553035474933676 0.280116147192013 no 916 0.290119559404509 323 915875
SGTC_1203 3992-3522 103 µM 0.552947504096795 0.280147256289812 no 917 0.290149678730744 357 5322312
SGTC_995 3931-2021 34.6 µM 0.552693245085447 0.280237179230247 no 918 0.290236739794857 319 730143
SGTC_558 k064-0027 21.3 µM 0.55251340681746 0.280300790474772 no 919 0.290298325770947 321 5088526
SGTC_2963 9082507 9 µM 0.551753597983134 0.280569622369116 no 920 0.290558591362523 328 16459611
SGTC_1509 1326-1131 80 µM 0.551575982994327 0.280632483234097 no 921 0.290619447499515 294 768313
SGTC_1892 st058411 7.36 µM 0.551291649024723 0.280733127883619 no 922 0.290716881120362 319 3934738
SGTC_2295 7971645 200 µM 0.548143460134792 0.281848645862937 no 923 0.291796700531914 335 2978226 YKL099C UTP11
SGTC_64 000l-0018 272.079 µM 0.547006612750455 0.282251996571833 no 924 0.292187094528549 315 6811119
SGTC_1991 st073000 8.92 µM 0.546831312040359 0.282314217551665 no 925 0.292247314505051 344 4301969 YIL048W NEO1
SGTC_320 4092-0846 5.34 µM 0.546379113104423 0.282474750847895 no 926 0.292402682278501 320 1359356
SGTC_526 4469-0568 170 µM 0.545848834722207 0.282663058711923 no 927 0.29258492571207 327 2901964
SGTC_2104 5389443 200 µM 0.545475052273615 0.282795829335647 no 928 0.292713417105427 332 2244536
SGTC_1115 galangin 695.678 nM 0.545422339323658 0.282814555822431 no 929 0.292731539808794 340 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1945 st075991 56.6 µM 0.544843080674194 0.283020379007046 no 930 0.292930723150682 294 1084980
SGTC_1649 st011737 51.3 µM 0.544332194663957 0.283201967559119 no 931 0.293106448121144 309 1761035
SGTC_2685 mycophenolic acid 18.85 µM 0.544149576691999 0.283266890572896 no 932 0.293169273479087 313 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1629 st005085 44.9 µM 0.542954959868503 0.283691768051838 no 933 0.293580406845305 323 24207091
SGTC_329 k048-0121 21.3 µM 0.542118930079661 0.283989291880073 no 934 0.293868289377598 317 6832902
SGTC_2434 5670830 169.91 µM 0.542005985442032 0.284029497730742 no 935 0.293907191288721 336 1549830
SGTC_1154 4088-0362 150 µM 0.539481513770555 0.28492886500363 no 936 0.294777324623548 321 6618304
SGTC_610 4215-0184 155 µM 0.537605918899051 0.285597941965721 no 937 0.295424571536034 307 5605015
SGTC_2958 9077254 16.72 µM 0.534685808888702 0.286641112370012 no 938 0.296433568074083 308 16457351
SGTC_2831 7999036 19.48 µM 0.534593372356802 0.286674163573715 no 939 0.296465533791187 345 2988270
SGTC_1497 4476-2978 41.3 µM 0.531173019880884 0.28789839856592 no 940 0.29764944373939 335 1528379
SGTC_1487 3970-0795 2.82 µM 0.530201457547929 0.288246596219649 no 941 0.297986130294563 317 3765103
SGTC_439 amiodarone 34.4 µM 0.528747559166363 0.288768028709894 no 942 0.298490290226335 352 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1579 chlormadinone acetate 49.4 µM 0.52868714739575 0.288789704658751 no 943 0.298511247261775 360 45114258 A steroidal progestin.
SGTC_1469 k284-2957 126 µM 0.528238027710168 0.288950874340324 no 944 0.298667069291368 326 23884841
SGTC_567 1080-0542 68.4 µM 0.52792953699086 0.289061602865166 no 945 0.298774121536007 311 5950415
SGTC_2997 9067075 71.4286 µM 0.527646552382112 0.289163193867775 no 946 0.298872338000528 345 27209819
SGTC_2000 st075254 36.4 µM 0.527282970391541 0.289293743830729 no 947 0.298998549208299 314 17234175
SGTC_3090 9117696 49.47 µM 0.526483663286188 0.289580845250117 no 948 0.299276099921522 327 7923821
SGTC_1552 6-methylflavone 10.6 µM 0.526191285004908 0.289685897389207 no 949 0.299377654293906 336 689013
SGTC_1502 4534-4282 27.7 µM 0.525830731747623 0.289815469565484 no 950 0.299502910006687 351 3278949
SGTC_3170 9103054 49.47 µM 0.525593465336442 0.289900750925907 no 951 0.299585348993622 335 16432970
SGTC_1003 4049-0218 100 µM 0.525348435348059 0.289988835122817 no 952 0.299670496252063 330 295161
SGTC_1553 gossypol 38.6 µM 0.524348085069327 0.29034857449635 no 953 0.300018228953336 332 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2276 7947513 42.08 µM 0.523754301896065 0.290562205673206 no 954 0.300224720784686 319 2105100
SGTC_730 1436-0052 41.2 µM 0.520234714551037 0.291829989496909 no 955 0.301449996275523 308 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_835 0312-0010 67.2 µM 0.520015728127937 0.29190895526166 no 956 0.301526306434555 331 1626196
SGTC_2938 9059746 27.26 µM 0.519639216331427 0.29204474740301 no 957 0.301657529746183 339 6471769
SGTC_157 1348-1695 65.819 µM 0.518842616496875 0.292332144703994 no 958 0.301935248339261 341 5380510
SGTC_1855 st056195 39.6 µM 0.518759010984572 0.292362315526923 no 959 0.301964402387491 323 4028379
SGTC_2306 7482397 179.52 µM 0.518748550998498 0.292366090336728 no 960 0.301968049974485 362 891448
SGTC_1736 st036774 51 µM 0.517949058851939 0.292654678870035 no 961 0.302246905945281 338 1272247
SGTC_2423 st077119 87.2 µM 0.516226159793937 0.293277034215941 no 962 0.302848230749457 316 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1949 st076024 69.1 µM 0.515398874088937 0.293576088880011 no 963 0.303137159545273 321 2921930
SGTC_3078 9116413 49.47 µM 0.515247229126105 0.293630922172123 no 964 0.303190134781331 321 17177322
SGTC_1896 st058441 89 µM 0.513801007460439 0.29415409942333 no 965 0.303695561750366 325 688759
SGTC_1282 0886-0010 32.4 µM 0.512626418160343 0.294579329151737 no 966 0.304106334894181 352 2836211 YNL267W PIK1
SGTC_2435 5706476 10.6 µM 0.51217179245728 0.294743990746985 no 967 0.304265391394761 311 5725375
SGTC_2312 7706453 155.7 µM 0.511407904526376 0.295020760038945 no 968 0.304532730555022 343 976098
SGTC_427 1354-0053 47.3 µM 0.511017227679866 0.295162355009751 no 969 0.304669496776677 350 6813657
SGTC_85 0868-0259 160.055 µM 0.510847373141486 0.295223926000628 no 970 0.304728967132818 339 83173
SGTC_739 1486-1183 203 µM 0.510797882925323 0.295241866943486 no 971 0.304746295876111 333 4346692
SGTC_2285 7945142 200 µM 0.5099427979103 0.295551927250402 no 972 0.305045768617248 350 2970608
SGTC_2390 9097792 176.6 µM 0.509814036233888 0.295598630177235 no 973 0.305090875583287 317 4497149
SGTC_2879 9041815 71.43 µM 0.508796923726539 0.295967664498412 no 974 0.305447287957685 317 4942971
SGTC_342 k048-0088 23.3 µM 0.508384250447254 0.296117453170054 no 975 0.30559194785585 313 6820570
SGTC_775 4577-0580 57.3 µM 0.508349235924558 0.296130164047439 no 976 0.305604223363185 346 2006902
SGTC_1733 st037357 54.9 µM 0.508171744631038 0.296194600307734 no 977 0.305666452209537 351 1272339 YGL099W LSG1
SGTC_2641 levomentholum 100 µM 0.50815687670243 0.296199998237498 no 978 0.305671665193524 341 16666
SGTC_16 erodoxin 22.806 µM 0.505543430444057 0.297149532719067 no 979 0.306588601261438 339 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1158 4092-0494 91.8 µM 0.504238376538447 0.29762421386641 no 980 0.307046937760105 345 1148199
SGTC_1404 3909-7820 48.3 µM 0.502839818363713 0.298133288686762 no 981 0.307538447966095 335 23741373
SGTC_3320 9137005 35.139 µM 0.50159518611157 0.298586667813865 no 982 0.307976153152878 349 4908713
SGTC_138 0850-0259 40.9225 µM 0.500958451880026 0.298818730603193 no 983 0.308200181944832 333 6813004
SGTC_733 4069-0007 56.1 µM 0.498958504836726 0.299548159433025 no 984 0.308904308483614 339 5717425 YNL287W SEC21
SGTC_1157 4092-0394 27.6 µM 0.497664020579149 0.300020718779579 no 985 0.309360435810038 316 3659885
SGTC_44 0929-0055 61.211 µM 0.497383519198185 0.300123161959239 no 986 0.309459312662539 322 1379590
SGTC_1035 k081-0041 55.2 µM 0.496986064659852 0.300268345213794 no 987 0.309599439173146 341 731709
SGTC_2350 9023895 38.85 µM 0.496797861467352 0.300337103651902 no 988 0.30966580172004 339 2997209
SGTC_2752 diclazuril 33.15 µM 0.49667426205385 0.30038226351848 no 989 0.309709387628981 352 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_611 3453-1652 23.7 µM 0.496357237894521 0.300498109555223 no 990 0.309821194777847 343 1560575
SGTC_2744 captopril 92.04 µM 0.495982343669086 0.30063512833476 no 991 0.309953434076831 310 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2471 5466956 24.79 µM 0.494887304506143 0.301035511773501 no 992 0.310339836357044 325 724419
SGTC_2659 sanguinarine 24.21 µM 0.494858033866583 0.301046217409095 no 993 0.310350167851439 342 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3083 9117465 49.47 µM 0.492640173333656 0.301857890824981 no 994 0.311133428487734 365 16420915
SGTC_1121 fusaric acid 630.51 nM 0.490531564988663 0.302630491736119 no 995 0.311878899648963 315 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1261 0712-0010 12.7 µM 0.48694474143804 0.303946746732038 no 996 0.313148745573148 354 2840123
SGTC_613 3914-0030 117 µM 0.486495822751116 0.304111665809395 no 997 0.313307833160924 336 1145395
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.485844553819012 0.304350993075044 no 998 0.313538691296547 328 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_488 nitrendipine 139 µM 0.485644713840317 0.304424446760449 no 999 0.313609544096205 342 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1001 4048-4355 44.4 µM 0.485427135887885 0.304504429231141 no 1000 0.313686693672469 369 21824233
SGTC_1997 st073024 93.8 µM 0.484233444582127 0.30494340089487 no 1001 0.314110101962785 341 686268
SGTC_918 glabranin 770.725 nM 0.484207379421305 0.304952989311816 no 1002 0.314119350138863 345 124049 Also referred to as licorice root.
SGTC_2566 crystal violet carbinol 226 nM 0.483280305061839 0.305294113029092 no 1003 0.314448361132144 364 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2157 5649910 96.377 µM 0.482904872754294 0.305432304205444 no 1004 0.314581640897738 338 2858091
SGTC_2908 7930301 100 µM 0.482304973695565 0.305653175878672 no 1005 0.314794657286425 327 2223178
SGTC_1764 st044502 93.5 µM 0.481409315243452 0.305983072280732 no 1006 0.315112808707311 325 8407
SGTC_1019 4262-0212 3.4 µM 0.481209705086958 0.306056615824815 no 1007 0.315183731956149 335 4677213
SGTC_2244 6635614 200 µM 0.480356547340071 0.306371037843659 no 1008 0.315486943188325 345 836499
SGTC_1109 tnp00067 928.257 nM 0.479835936675286 0.306562973337077 no 1009 0.315672028661441 338 676295
SGTC_1104 tacrolimus 29.8 µM 0.479441132675738 0.306708562599267 no 1010 0.315812418671818 358 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_727 3032-0951 202 µM 0.479353070368326 0.306741040915694 no 1011 0.315843736742805 356 3652836
SGTC_2147 5545932 89.7195 µM 0.47894111845286 0.306892993315429 no 1012 0.315990258968007 366 797404
SGTC_1878 temozolomide 1 mM 0.478201026099482 0.307166066795478 no 1013 0.316253566137069 352 5394 DNA alkylating agent.
SGTC_986 1493-0483 84 µM 0.477433403490284 0.30744941119458 no 1014 0.316526766381002 364 40079
SGTC_449 xestospongin c 11.1929 µM 0.477175544616923 0.307544617706979 no 1015 0.316618561958124 376 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2331 7980721 200 µM 0.476112658559315 0.307937192729828 no 1016 0.316997059589059 352 2981221
SGTC_2355 9061122 103.12 µM 0.476068795799077 0.30795339808795 no 1017 0.317012683397773 378 5302957
SGTC_1078 idebenone 36.1 µM 0.475793648527104 0.308055061429216 no 1018 0.317110697629419 355 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_22 0964-0034 14.468 µM 0.475234586042489 0.308261673118493 no 1019 0.317309888968368 359 138402
SGTC_2396 5342950 42.78 µM 0.475158292179674 0.308289873613417 no 1020 0.31733707621906 341 1886677
SGTC_276 colchicine 750 µM 0.474328961830699 0.30859649189819 no 1021 0.317632670917969 360 2833 A microtubule depolymerizer.
SGTC_2923 7992654 58.14 µM 0.474310347235984 0.308603375580026 no 1022 0.317639306974124 315 2985126
SGTC_2161 5662504 8.5105 µM 0.474174743874672 0.308653523767048 no 1023 0.31768765099901 315 2859334
SGTC_1335 1486-0900 202 µM 0.473553166046194 0.308883438369841 no 1024 0.317909289805782 338 X1335
SGTC_819 1013-0258 27.7 µM 0.473163118220955 0.30902775090339 no 1025 0.31804840423927 342 5753198
SGTC_2199 6590217 200 µM 0.472032951956808 0.309446063860744 no 1026 0.318451634195972 347 703109
SGTC_3164 9100705 49.47 µM 0.47166299246212 0.30958305214368 no 1027 0.318583678134357 353 17174235
SGTC_1786 berberine 21.6 µM 0.471005839085983 0.309826447560017 no 1028 0.318818282566296 375 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_831 k061-1017 217 µM 0.469572395996299 0.310357653151971 no 1029 0.319330275107697 370 1240153
SGTC_483 fpl-64176 144 µM 0.468702918034856 0.310680057399911 no 1030 0.319641000443968 370 3423
SGTC_1969 st069479 40.1 µM 0.468270444578047 0.310840473641914 no 1031 0.319795600659206 362 3895485
SGTC_1450 4112-4260 37.6 µM 0.466710863748615 0.311419263340368 no 1032 0.32035337808081 355 1633175
SGTC_1739 st037196 92.5 µM 0.46508186121923 0.312024314795043 no 1033 0.320936417519127 368 612214
SGTC_1721 st082152 9.2685 µM 0.463014163075391 0.312793039401173 no 1034 0.32167710761079 350 5296051
SGTC_3156 9099931 49.47 µM 0.461825762284556 0.31323522963302 no 1035 0.322103137334857 348 18111053
SGTC_2252 omeprazole 400 µM 0.460184995503507 0.313846181516082 no 1036 0.32269171998551 344 4594 A proton pump inhibitor.
SGTC_2040 5100729 123 µM 0.458664646080045 0.314412751073824 no 1037 0.32323750288632 340 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_3128 9127691 49.47 µM 0.458485892932783 0.314479393531332 no 1038 0.323301697648111 376 41316314
SGTC_704 1310-0270 142 µM 0.457960543943415 0.314675288274241 no 1039 0.323490394162813 370 5718033
SGTC_2657 nystatin 74.44 µM 0.457774065179935 0.314744835951916 no 1040 0.323557385116804 346 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2507 purpurin 79.67 µM 0.457714167143483 0.314767176454998 no 1041 0.323578904204754 348 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1960 st011366 51.8 µM 0.457584022837762 0.314815719435737 no 1042 0.323625662140878 347 3972846
SGTC_702 1488-0190 94 µM 0.45743278223611 0.314872135217813 no 1043 0.323680003002173 340 949357
SGTC_1665 st014639 11.4 µM 0.456257251410434 0.315310779034312 no 1044 0.324102500205584 343 981133 YIL048W NEO1
SGTC_659 k018-0002 107 µM 0.454993376684632 0.315782678539463 no 1045 0.324557001908826 362 6797879 YHR007C ERG11
SGTC_2953 9074162 66.49 µM 0.45423922133218 0.316064404641152 no 1046 0.324828328123963 367 16451992
SGTC_656 4090-1979 187 µM 0.453496058313824 0.316342128915213 no 1047 0.325095790513751 367 22330961
SGTC_2905 7799065 20.05 µM 0.453003013088822 0.316526439926871 no 1048 0.325273285931319 370 1296806
SGTC_183 3914-0051 30.55 µM 0.452687545094852 0.316644392624215 no 1049 0.325386874658808 341 1596232
SGTC_1375 2910-0797 186 µM 0.452672123445504 0.31665015921865 no 1050 0.325392427858455 369 742508
SGTC_2945 9067681 61.76 µM 0.45235324064497 0.316769408575933 no 1051 0.325507263423799 384 16456930
SGTC_2858 9025781 8.96 µM 0.451509838172679 0.317084898977911 no 1052 0.325811068001352 343 4894980 YPL153C RAD53
SGTC_959 1222-0044 107 µM 0.450511407132088 0.317458552625714 no 1053 0.326170865449943 376 6083612
SGTC_2164 5685496 200 µM 0.450468217968386 0.317474719974888 no 1054 0.326186432874392 337 759046
SGTC_2692 st077426 47.7 µM 0.44965812354508 0.317778033662749 no 1055 0.326478485446933 362 25238571
SGTC_2980 9014342 25.29 µM 0.449279916570427 0.31791968294457 no 1056 0.326614871823216 376 2996599
SGTC_344 k064-0035 6.43 µM 0.449170561581016 0.317960644468916 no 1057 0.326654310981297 368 5088750
SGTC_708 3448-5400 146 µM 0.448130601191018 0.318350297729339 no 1058 0.327029472130017 365 3462195
SGTC_814 3342-0569 96 µM 0.444761291323708 0.3196140928047 no 1059 0.328246135333953 373 4346283
SGTC_1575 cyproterone acetate 48 µM 0.444632463314415 0.319662456652898 no 1060 0.328292691621404 379 9880 An androgen receptor antagonist and liver toxin.
SGTC_2572 astragaloside iv 100 µM 0.443328181327182 0.320152275053049 no 1061 0.328764187383344 342 45006101 An anti-inflammatory agent.
SGTC_2888 9058547 12.99 µM 0.443139781909849 0.320223053715854 no 1062 0.328832316014559 351 16476514
SGTC_2603 homopterocarpin 100 µM 0.442358902158749 0.320516487535813 no 1063 0.329114756858464 359 101795 A weak amylase inhibitor.
SGTC_2241 6772625 37.8075 µM 0.442320633073484 0.320530870925242 no 1064 0.329128601131235 348 2285411
SGTC_440 fluspirilene 35.1 µM 0.439014775014082 0.321774389015941 no 1065 0.330325415281282 363 3396 An atypical antipsychotic.
SGTC_1444 4112-3581 28 µM 0.438667363859264 0.321905186090519 no 1066 0.330451289064367 353 2877249
SGTC_1831 st055328 12 µM 0.438177144559593 0.322089786643711 no 1067 0.330628937632706 350 1103068
SGTC_2181 6316240 54.2555 µM 0.43798685827173 0.322161454065867 no 1068 0.330697904986687 357 12779990
SGTC_803 4488-1585 147 µM 0.43793766770345 0.32217998175888 no 1069 0.330715734549259 370 747204
SGTC_1505 k297-0037 20.6 µM 0.437404141264289 0.32238096358049 no 1070 0.330909140659118 346 4089396
SGTC_1663 st014140 55.4 µM 0.436401197851827 0.322758917425162 no 1071 0.331272835013681 368 4207120
SGTC_3060 1327-0027 12.5 µM 0.435260762037046 0.323188907096692 no 1072 0.331686581263744 336 16000455 YPR107C YTH1
SGTC_316 k060-0003 58.6 µM 0.435195431804036 0.323213546356021 no 1073 0.331710289076216 371 6152314
SGTC_946 3434-1334 87.4 µM 0.433460167244901 0.323868283968647 no 1074 0.33234024900401 353 4047976
SGTC_597 k018-0003 82.8 µM 0.432113851106282 0.324376642191457 no 1075 0.332829334084495 385 6786234
SGTC_1653 st012112 65 µM 0.431942143829716 0.324441501054635 no 1076 0.332891731790817 365 720429
SGTC_3209 9113616 49.47 µM 0.431849487561376 0.324476502251165 no 1077 0.332925404613898 392 16649353
SGTC_399 oxolinic acid 75 µM 0.431545187060556 0.324591463628496 no 1078 0.333036001935393 354 4628 A DNA gyrase inhibitor.
SGTC_2978 9011784 42.97 µM 0.430669757965051 0.324922284277736 no 1079 0.333354255607366 364 2994934
SGTC_1033 k072-0102 21.3 µM 0.430061525909781 0.325152213717593 no 1080 0.333575443081322 355 5965931
SGTC_2058 5236698 133 µM 0.429744199864464 0.325272198649885 no 1081 0.333690863699715 349 766665
SGTC_2616 abietic acid 100 µM 0.429647333478629 0.325308828647199 no 1082 0.333726099929335 370 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_912 3474-0017 2.18 µM 0.429395986390548 0.325403883350894 no 1083 0.333817537078457 382 3360550
SGTC_1612 st002233 45.4 µM 0.428720254419534 0.325659488674955 no 1084 0.334063409433854 359 1035021
SGTC_794 k038-0031 316 µM 0.427838193516591 0.325993264238599 no 1085 0.334384463968338 363 6624242
SGTC_679 0422-0091 41.4 µM 0.427246634188842 0.326217190938112 no 1086 0.334599848979439 371 627384 YHR062C RPP1
SGTC_2891 9063876 19.48 µM 0.425252758473425 0.326972406532339 no 1087 0.335326213910744 369 6472478
SGTC_2804 7954240 19.48 µM 0.425211102664124 0.326988191978237 no 1088 0.335341395617607 348 828705
SGTC_518 1021-0119 62.6 µM 0.424385919958815 0.327300958283336 no 1089 0.33564219374864 363 1097762
SGTC_2742 clothiapine 36.27 µM 0.423383248708693 0.327681160705315 no 1090 0.336007832317851 375 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2226 7298446 200 µM 0.422931542537788 0.327852501368769 no 1091 0.336172604247499 391 3283010
SGTC_1137 ixabepilone 100 µM 0.421239836932924 0.328494519001742 no 1092 0.336789978702867 349 154225 A novel microtubule stabilizer.
SGTC_1862 st057513 3.81 µM 0.420753065421205 0.328679347166913 no 1093 0.336967703681322 361 5393163
SGTC_2459 5811157 9.22 µM 0.41865765650653 0.329475456449525 no 1094 0.337733172912881 371 2870684 YBR192W RIM2
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.41837293368909 0.329583691041241 no 1095 0.337837236286421 391 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_432 NS 1619 61.3 µM 0.417903107734188 0.329762321990561 no 1096 0.338008980128148 340 4552 A K+/calcium channel activator.
SGTC_1675 st018485 24.5 µM 0.417898141440464 0.32976421041593 no 1097 0.338010795726045 350 3323024
SGTC_1271 0832-2808 169 µM 0.417578819722275 0.329885641104535 no 1098 0.338127542569541 384 3663794
SGTC_3183 9108214 49.47 µM 0.417251992375884 0.330009944577248 no 1099 0.338247049658481 360 4974831
SGTC_3138 9097216 49.47 µM 0.416609009679568 0.330254547380741 no 1100 0.338482209096614 391 25237486
SGTC_1087 pterostilbene 9.05 µM 0.415558697200533 0.330654262184678 no 1101 0.338866477601687 375 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2845 9003024 42.97 µM 0.415095209345637 0.330830712073241 no 1102 0.339036103158704 347 2990173
SGTC_2960 9079389 5.97 µM 0.414959700884516 0.330882307266284 no 1103 0.339085702207397 354 16457355
SGTC_1618 st003135 44.5 µM 0.414325664973955 0.331123760727687 no 1104 0.339317810204886 393 1270615
SGTC_937 3122-0005 46.7 µM 0.413909718165141 0.331282199692002 no 1105 0.339470113229342 358 759535
SGTC_1874 staurosporine 7.6 µM 0.412446109709508 0.331839945115885 no 1106 0.340006236227492 377 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1106 tegaserod maleate 11.7 µM 0.411328193153566 0.332266207074087 no 1107 0.340415949641402 379 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1988 st071872 53.4 µM 0.40949316122531 0.332966375801899 no 1108 0.341088892249354 358 16414116
SGTC_561 1550-0330 72.9 µM 0.407733208294295 0.333638445223084 no 1109 0.341734777163115 385 6812934
SGTC_2203 7227154 166.4 µM 0.407035275379652 0.333905111402959 no 1110 0.34199103996222 364 896304
SGTC_3106 9121286 49.47 µM 0.402001199160948 0.335831008929044 no 1111 0.343841571876334 336 15943471
SGTC_3019 9081971 49.47 µM 0.401914085981475 0.335864374168679 no 1112 0.343873627886165 379 16451803
SGTC_2301 7769476 200 µM 0.40190636595564 0.335867331080021 no 1113 0.343876468764458 371 977820
SGTC_3232 9132874 49.47 µM 0.401532965124604 0.336010362566853 no 1114 0.344013886379441 367 3784940
SGTC_2644 guaiazulene 100 µM 0.401223879642531 0.336128775975281 no 1115 0.344127650481482 376 3515 A coloring agent.
SGTC_3356 9151811 4.48 µM 0.401133012766596 0.336163590980776 no 1116 0.344161098245113 371 1859254 YPR165W RHO1
SGTC_1735 st034310 56.75 µM 0.400767571342587 0.336303621484918 no 1117 0.34429562820139 416 871153
SGTC_1484 3473-2379 286 µM 0.400090912625056 0.336562964745082 no 1118 0.344544778593288 377 671917
SGTC_3257 9139206 32.98 µM 0.39742036938143 0.337587262997337 no 1119 0.345528748563985 376 4910041
SGTC_1262 0737-0114 49.6 µM 0.397019341539442 0.337741183130969 no 1120 0.34567659889877 398 765919
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.396971294506721 0.337759626080017 no 1121 0.345694314385349 371 688801
SGTC_1316 1272-0050 65.9 µM 0.396800191039184 0.337825307649933 no 1122 0.345757404920847 373 7340392
SGTC_1272 0839-0021 27 µM 0.396713083245791 0.337858747657522 no 1123 0.345789525595988 406 5027250
SGTC_3259 9138485 49.47 µM 0.395985095690442 0.338138266463816 no 1124 0.346058011684725 352 17646153
SGTC_247 mechlorethamine 29.705 µM 0.395291923983804 0.338404500296482 no 1125 0.346313729429337 373 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_198 3454-2873 16.191 µM 0.394076396192566 0.338871555999237 no 1126 0.34676231850927 377 710957
SGTC_560 2332-1943 155 µM 0.392404483101317 0.339514378442377 no 1127 0.34737968705228 365 21177716
SGTC_3033 9090887 49.47 µM 0.387290472753531 0.341483522744866 no 1128 0.349270588959746 367 19325384
SGTC_1005 4092-0690 4.4 µM 0.38719335070185 0.341520961481445 no 1129 0.349306536180398 386 1529343
SGTC_2551 apiole 73.87 µM 0.386616385682986 0.341743402854529 no 1130 0.349520112749375 381 10659 A possible DNA adduct former.
SGTC_2647 atorvastatin 60.16 µM 0.38656733621819 0.341762315774821 no 1131 0.349538271709465 382 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1026 k007-1105 30.6 µM 0.384657618259985 0.342498989846529 no 1132 0.350245549632406 360 7066794
SGTC_3086 9117350 49.47 µM 0.384552437937716 0.342539580620931 no 1133 0.350284519050407 366 2679265
SGTC_895 0964-0006 13.7 µM 0.383999204287542 0.34275311229361 no 1134 0.350489518630077 395 6738897
SGTC_2853 9015042 58.44 µM 0.38333456637875 0.343009709126598 no 1135 0.350735856415599 351 6457456
SGTC_102 gallobenzophenone 83.616 µM 0.381767426414981 0.343615021541548 no 1136 0.351316940985203 400 70837
SGTC_1931 st074438 57.1 µM 0.378218963904519 0.344987106395708 no 1137 0.352633969426108 415 2787313
SGTC_1049 3226-0134 66 µM 0.378095529688938 0.34503487156466 no 1138 0.352679814527879 365 5702385
SGTC_1387 3342-1166 1.8 µM 0.377531387450697 0.34525320833478 no 1139 0.352889371650915 371 3418228
SGTC_881 0833-0569 170 µM 0.377157776725374 0.345397833133937 no 1140 0.353028178224764 356 5418700
SGTC_3068 9116768 49.47 µM 0.376486261855255 0.345657833438496 no 1141 0.353277713476294 405 41904888
SGTC_186 3455-3465 67.277 µM 0.375922221021367 0.345876277714012 no 1142 0.353487360083252 398 755278
SGTC_2014 4013930 200 µM 0.374144273439871 0.346565184759471 no 1143 0.35414849063003 404 64556
SGTC_193 1273-0060 1.558 µM 0.371835354491684 0.347460586637204 no 1144 0.355007719462973 381 2847393 YHR072W ERG7
SGTC_140 0062-0056 502.533 µM 0.37139799002193 0.347630293281269 no 1145 0.35517056121109 351 3758964
SGTC_3125 9127534 49.47 µM 0.370749612081633 0.347881933792263 no 1146 0.355412017229063 376 1639235
SGTC_1555 citronellol 128 µM 0.370590934844491 0.347943527871115 no 1147 0.355471117494992 397 8842 A terpine precursor.
SGTC_1880 MG-132 525 µM 0.37027609997232 0.348065749866848 no 1148 0.355588389873885 418 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1066 ketoconazole 628 nM 0.369040196722332 0.34854569216891 no 1149 0.356048881742023 408 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2217 6934799 96.0675 µM 0.368759849865428 0.34865459394506 no 1150 0.356153366944841 383 675606
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.368537550961255 0.348740955645335 no 1151 0.356236225369495 386 521171
SGTC_1292 0kpi-0043 232 µM 0.368422400188304 0.348785694064974 no 1152 0.356279148680521 404 3333905
SGTC_511 blebbistatin 171 µM 0.366645710040703 0.349476240521416 no 1153 0.356941653714898 391 3476986 A myosin inhibitor.
SGTC_2852 9023854 51.95 µM 0.366572486805254 0.349504710918733 no 1154 0.35696896699804 430 19798528
SGTC_760 0568-0725 82.9 µM 0.366168259152655 0.349661896506697 no 1155 0.357119762714781 400 3916171
SGTC_2446 5162541 200 µM 0.365318835676954 0.349992282289717 no 1156 0.357436709891486 382 1549321
SGTC_2256 7954252 200 µM 0.365102595607521 0.35007640765617 no 1157 0.357517411721741 401 2972920
SGTC_1330 1469-0054 61.8 µM 0.360586427971588 0.351835039526695 no 1158 0.359204318300746 411 7102664
SGTC_1616 st002734 56.1 µM 0.359121271312138 0.352406267187416 no 1159 0.359752184690495 402 4026101
SGTC_3171 9103192 49.47 µM 0.358149892813027 0.352785166884429 no 1160 0.360115571510929 399 13018434
SGTC_622 1348-1566 26.3 µM 0.357800924886791 0.352921322361539 no 1161 0.360246149188717 392 7340407
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.356727494603723 0.353340256556842 no 1162 0.360647910130183 368 2333 A French combination drug.
SGTC_2523 spermine 47.74 µM 0.356703346477403 0.353349683039985 no 1163 0.360656950004878 375 1103 A DNA binding polyamine.
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.356383816642947 0.353474423447079 no 1164 0.36077657364099 413 688669
SGTC_2123 5259487 200 µM 0.355979412768126 0.353632320170625 no 1165 0.36092799143415 404 2173474
SGTC_2893 9048488 25.97 µM 0.353896040861733 0.354446157038046 no 1166 0.361708397110784 382 6467338
SGTC_690 glyoxal 20.3 µM 0.352940934741942 0.354819476959133 no 1167 0.362066360807086 385 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.352326264862115 0.355059805203303 no 1168 0.362296796438725 400 756377
SGTC_3300 9124615 50.48 µM 0.352163176808092 0.355123580280114 no 1169 0.362357945441725 380 24824903
SGTC_3177 9107506 49.47 µM 0.350995692352732 0.355580239873152 no 1170 0.362795790037215 417 8897194
SGTC_1522 st012842 45.6 µM 0.350506699067921 0.355771570437949 no 1171 0.36297923175711 406 3491067 YOR116C RPO31
SGTC_1998 st075797 76.8 µM 0.348731531792885 0.356466453082956 no 1172 0.363645434821486 416 24208315
SGTC_2048 5246248 200 µM 0.348128783625103 0.356702505160187 no 1173 0.363871734276273 387 677046
SGTC_1315 1237-0019 3.69 µM 0.34767247917943 0.356881242525417 no 1174 0.364043083593778 399 825140
SGTC_2653 dihydrofissinolide 100 µM 0.347451052694039 0.356967988019916 no 1175 0.364126242433824 388 6857746
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.347276084280559 0.357036538445526 no 1176 0.364191958024907 373 688664
SGTC_1455 4262-0120 131 µM 0.346424631246243 0.357370192890286 no 1177 0.364511808364318 370 1529587
SGTC_253 dyclonine 31.25 µM 0.346191658183857 0.357461505840001 no 1178 0.364599341694226 376 3180 An oral anasthetic.
SGTC_1202 1988-0068 29.6 µM 0.344599169240294 0.35808589443497 no 1179 0.365197865214202 375 2850480
SGTC_2710 st078562 53.7235 µM 0.344129925376343 0.358269949713012 no 1180 0.365374289284478 412 17250908
SGTC_1226 3909-7979 35.4 µM 0.34367572338039 0.358448136370613 no 1181 0.36554508512139 395 6615510
SGTC_2296 7971656 126.45 µM 0.342463617053284 0.358923805060461 no 1182 0.366001009931081 392 666570
SGTC_197 4544-0043 41.561 µM 0.340825589068828 0.359566966422116 no 1183 0.366617442660321 396 896523
SGTC_1796 st049173 110.4 µM 0.340642476789571 0.359638889069521 no 1184 0.366686374014162 413 94134
SGTC_2381 9035592 200 µM 0.339450026050832 0.360107380114854 no 1185 0.367135368946229 393 4749657
SGTC_1581 himbacine 57.9 µM 0.339242070240725 0.360189103511174 no 1186 0.36721368943201 404 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2706 st078239 82.5 µM 0.33908443231108 0.360251057021396 no 1187 0.367273062838812 407 15434492
SGTC_2687 chenodiol 100 µM 0.338317863780306 0.360552379515297 no 1188 0.367561831622945 378 5702181 A cholesterol synthesis inhibitor.
SGTC_166 k072-0058 166.424 µM 0.336052264078794 0.361443446308458 no 1189 0.368415727416992 419 5846229
SGTC_1853 st056710 91.2 µM 0.335584959979681 0.361627332055618 no 1190 0.368591933565899 410 269167
SGTC_2358 9037157 4 µM 0.335227909398989 0.361767854211621 no 1191 0.368726585095392 382 2388925
SGTC_3133 9127736 49.47 µM 0.333129030832214 0.362594272987001 no 1192 0.369518443143884 405 27243420
SGTC_361 000s-0510 1.45 µM 0.331802229006369 0.363117022664271 no 1193 0.370019300522538 374 660
SGTC_2626 ethyl orsellinate 100 µM 0.331770561339967 0.363129502601202 no 1194 0.370031257518387 389 75653 A natural product.
SGTC_764 1951-2361 146 µM 0.331395726112959 0.363277232763766 no 1195 0.370172796378017 404 5438930
SGTC_1244 0416-0015 52.5 µM 0.331185437522356 0.363360120668643 no 1196 0.370252209654838 406 96201
SGTC_3271 9137798 49.47 µM 0.330693175179413 0.363554177103916 no 1197 0.370438128978767 388 6498326
SGTC_1828 st055811 49 µM 0.330474929931715 0.363640223521603 no 1198 0.370520566276512 423 5877589
SGTC_1852 st056254 31.4 µM 0.328171089721049 0.364548965403365 no 1199 0.37139115276883 418 442583
SGTC_1936 st074407 74.3 µM 0.327877560957141 0.364664801633007 no 1200 0.371502120241809 384 809813
SGTC_2787 5284540 71.43 µM 0.327447145560466 0.364834680230971 no 1201 0.371664856514604 413 736958
SGTC_1870 st057514 26.5 µM 0.326757002168132 0.365107125012899 no 1202 0.371925841520419 388 5393161
SGTC_471 1-acyl-paf 4 µM 0.325849212318194 0.365465592793681 no 1203 0.372269221445075 378 16759367
SGTC_3076 9116187 49.47 µM 0.325374146049763 0.365653233691244 no 1204 0.372448960172545 420 27241210
SGTC_3279 9140807 49.47 µM 0.323512309426228 0.366388928411177 no 1205 0.37315364337604 425 45595718
SGTC_2820 7989630 71.43 µM 0.322451343056364 0.366808383497989 no 1206 0.373555396683098 381 2984098
SGTC_515 4092-1064 102 µM 0.32229800229808 0.366869020230101 no 1207 0.373613473198626 433 717353
SGTC_2370 9071495 200 µM 0.321718216514004 0.367098319459009 no 1208 0.373833088094789 418 21791103
SGTC_1672 st016598 6.51 µM 0.321357701656349 0.367240923237079 no 1209 0.373969666835355 422 4665860 YNL267W PIK1
SGTC_884 0851-0618 334 µM 0.320141775285154 0.367722025034377 no 1210 0.374430429334891 430 9642473
SGTC_2798 7813637 45.45 µM 0.319889263548392 0.367821961627652 no 1211 0.374526138515782 439 956368
SGTC_1622 st003707 19.4 µM 0.319822239507658 0.367848489241557 no 1212 0.374551543845608 404 10140899
SGTC_2638 epoxomicin 18 µM 0.319661744284877 0.367912014611804 no 1213 0.374612381454964 422 9915668 A protesome inhibitor.
SGTC_2881 9058953 51.95 µM 0.318571517793194 0.368343631048056 no 1214 0.375025727223392 377 17122249
SGTC_1297 1068-0111 14.1 µM 0.317257631933525 0.368864014168964 no 1215 0.375524061402401 398 767057
SGTC_3158 9100007 49.47 µM 0.31486677616609 0.369811562922306 no 1216 0.376431404119407 380 19297233
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.313224310561796 0.370462966925772 no 1217 0.3770551249447 422 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_903 1134-0042 114 µM 0.311996760443122 0.370950057670624 no 1218 0.377521492666444 398 701009
SGTC_1136 pergolide 1.05886 µM 0.311580187965422 0.371115400289895 no 1219 0.377679796454547 430 47811 A dopamine receptor agonist.
SGTC_1927 st060202 13.8 µM 0.311216060836765 0.371259946210841 no 1220 0.377818187055277 417 688887
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.311045543416032 0.371327641995176 no 1221 0.377882999507159 413 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2351 9026858 72.31 µM 0.310772723073154 0.371435960539474 no 1222 0.377986703717262 412 1409300
SGTC_641 4092-0595 30 µM 0.308988101519837 0.372144764097891 no 1223 0.378665288935011 415 786260
SGTC_3214 9129694 49.47 µM 0.308931672909745 0.372167183101744 no 1224 0.378686751487283 438 17158655
SGTC_1621 st003705 32.4 µM 0.30780150395262 0.372616288720497 no 1225 0.379116688562947 394 24207032
SGTC_3099 9120367 49.47 µM 0.306679076263795 0.373062489595737 no 1226 0.379543828772574 443 24824940
SGTC_2764 methyldopa 94.69 µM 0.306452349232042 0.373152641532243 no 1227 0.379630127684273 428 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2802 7925815 54.55 µM 0.302627590687797 0.374674497587117 no 1228 0.381086842765956 390 1262923
SGTC_1037 k284-1091 78.7 µM 0.301695814865147 0.375045544354744 no 1229 0.38144197948476 414 3334711
SGTC_684 1140-0066 328 µM 0.300655324880469 0.375460019387585 no 1230 0.381838669470834 398 6813534
SGTC_2404 5161160 200 µM 0.300502889503882 0.375520753498965 no 1231 0.381896796356923 441 2831543
SGTC_2262 9014885 67.46 µM 0.300084333389379 0.375687532707296 no 1232 0.382056414490808 422 6457424
SGTC_676 falcarinol 140 µM 0.297813128782452 0.376592928442682 no 1233 0.382922896834815 427 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_581 0958-0271 211 µM 0.297042614653983 0.376900241687036 no 1234 0.383216987400414 394 4591145
SGTC_954 1189-0853 2.85 µM 0.296835318435985 0.376982933408693 no 1235 0.383296119916455 386 2828194
SGTC_3314 9135860 59.4275 µM 0.295792605970938 0.377398963255415 no 1236 0.383694235024507 430 25252478
SGTC_1758 st042942 75.2445 µM 0.295599086615509 0.377476190843229 no 1237 0.383768135627252 414 669317
SGTC_873 0591-4978 488 µM 0.295296832874374 0.377596820761215 no 1238 0.383883567854642 447 3305145
SGTC_1229 0139-0193 12.2 µM 0.294456820149027 0.377932133761849 no 1239 0.384204427026364 412 3090752
SGTC_2696 st077691 74.316 µM 0.294100227435093 0.378074504877273 no 1240 0.384340658548957 448 757133
SGTC_3194 9111903 49.47 µM 0.293992681588106 0.378117446252382 no 1241 0.384381747820233 432 17087251
SGTC_178 4092-0806 87.505 µM 0.293432597163086 0.378341103534348 no 1242 0.384595756254973 409 2169044
SGTC_2356 9061756 188.97 µM 0.292646966332105 0.378654896450514 no 1243 0.384896005302249 401 20104043
SGTC_520 3584-0023 682 µM 0.291827440824182 0.378982312687539 no 1244 0.385209281641338 375 1340790
SGTC_2575 plumbagin 510 nM 0.290694220292521 0.379435199173817 no 1245 0.385642596174233 411 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2215 7188065 200 µM 0.290524876319988 0.379502890957623 no 1246 0.385707361249605 434 940217
SGTC_1836 st055642 81 µM 0.290184451559748 0.37963897995549 no 1247 0.385837565279342 442 8571
SGTC_1634 st006576 41 µM 0.290064441442982 0.37968695903591 no 1248 0.385883469240571 447 3915356
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.290024069500814 0.379703099830435 no 1249 0.385898911898487 427 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_261 5-fluorouridine 15.376 µM 0.289645383145539 0.379854509699045 no 1250 0.3860437718872 392 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3000 9075062 71.4286 µM 0.289113847610411 0.380067064203477 no 1251 0.386247128515806 400 17057871
SGTC_1800 st050079 29.0735 µM 0.288650350447398 0.38025244057535 no 1252 0.386424480308468 417 3645560
SGTC_642 0335-0876 158 µM 0.288069401301425 0.380484830884737 no 1253 0.386646807241411 430 6812350
SGTC_732 3970-1727 52.7 µM 0.28798358778965 0.380519161521353 no 1254 0.386679650887679 441 1275699
SGTC_1350 1495-0454 146 µM 0.287589047047991 0.380677013977444 no 1255 0.386830665014527 435 1069057
SGTC_1168 k815-0004 80.5 µM 0.287052691581713 0.380891637177345 no 1256 0.387035987519805 419 642433
SGTC_2495 cafestol 54.53 µM 0.285811167588693 0.381388574812269 no 1257 0.387511377136405 422 16667697 An anti-infammatory.
SGTC_3119 9125183 49.47 µM 0.284342320558059 0.381976754294777 no 1258 0.388074028421006 418 22695334
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.280561067767786 0.383492155495915 no 1259 0.389523540234699 415 688662
SGTC_113 0099-0221 2.5 µM 0.280081596160688 0.38368443980708 no 1260 0.389707452001143 450 89219
SGTC_450 aminopyrene 156 nM 0.279466963326225 0.383930970227613 no 1261 0.389943243916352 446 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_394 menadione 8.33 µM 0.278387259219448 0.384364155329332 no 1262 0.390357549390779 435 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2976 9009005 19.48 µM 0.278199853215601 0.38443935870226 no 1263 0.390429473765838 429 2993148
SGTC_1752 st044819 83.042 µM 0.277652170142609 0.384659161076604 no 1264 0.390639690025128 399 441209 YML126C ERG13
SGTC_1165 k072-0275 30.3 µM 0.27756292079798 0.38469498315005 no 1265 0.390673949479592 406 6153523 YGL055W OLE1
SGTC_3101 9120531 49.47 µM 0.277439226005561 0.384744632245189 no 1266 0.390721432644413 453 24824904
SGTC_983 1491-0821 12.2 µM 0.277394019209672 0.384762777995796 no 1267 0.39073878674637 392 46495113
SGTC_2020 4017018 200 µM 0.277167993332325 0.384853507282214 no 1268 0.390825557409388 426 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1801 st050089 28.441 µM 0.276159800741449 0.385258283663952 no 1269 0.391212665696086 398 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_977 1348-1378 135 µM 0.274225974185633 0.386035039798428 no 1270 0.391955484207672 446 X977
SGTC_2021 4019055 173 µM 0.273606557895291 0.386283936266008 no 1271 0.392193496889918 423 44827708 YER133W GLC7
SGTC_1028 k015-0029 4.8 µM 0.271797606009931 0.387011084520108 no 1272 0.392888823039534 411 4588309
SGTC_1515 3460-0031 42.1 µM 0.27155535880504 0.387108491323674 no 1273 0.392981964192989 430 2876596
SGTC_940 3232-1287 54.8 µM 0.271182222961032 0.387258541925511 no 1274 0.393125442448974 439 1585493 YIL048W NEO1
SGTC_2743 auranofin 4.32 µM 0.270813443458671 0.387406857247287 no 1275 0.393267259869535 440 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3049 9092223 49.47 µM 0.270787562393549 0.387417266682115 no 1276 0.393277213194231 429 8623917
SGTC_1605 st000082 49.1 µM 0.270567435850707 0.387505805447882 no 1277 0.393361872148795 442 1114022
SGTC_2982 9019404 25.97 µM 0.269930604861996 0.387761983001277 no 1278 0.393606820770482 368 22333232
SGTC_216 k038-0035 28.382 µM 0.269185457517182 0.388061794929845 no 1279 0.393893485303145 421 4444231 YPR107C YTH1
SGTC_534 k292-0788 63.4 µM 0.269059224877632 0.388112591567895 no 1280 0.393942053775289 441 4146317
SGTC_559 1550-0661 158 µM 0.268712193564251 0.388252248546332 no 1281 0.39407558384797 434 5830875
SGTC_2513 baicalein 25.65 µM 0.268258643095716 0.388434794168756 no 1282 0.394250118936008 418 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_442 cape 100 µM 0.268191128495995 0.388461969646906 no 1283 0.394276101690745 436 5281787
SGTC_685 1278-0033 54.9 µM 0.266783919622647 0.389028513068099 no 1284 0.394817767975759 455 3590572
SGTC_874 0599-0792 117 µM 0.26622668467931 0.389252921610526 no 1285 0.395032316486276 446 765305
SGTC_630 4356-0227 183 µM 0.266132097279213 0.389291017328846 no 1286 0.39506873801354 452 779312
SGTC_1094 duloxetine 25.4 µM 0.265893250142478 0.389387219371966 no 1287 0.395160711821952 416 60834 A selective serotonin reuptake inhibitor.
SGTC_1164 k060-0068 93.7 µM 0.265832853896803 0.389411546641961 no 1288 0.395183969767805 410 5963676
SGTC_2992 9074591 71.4286 µM 0.263019079480131 0.390545398166335 no 1289 0.396267936708319 415 17741321
SGTC_512 prima-1 270 µM 0.261794854612329 0.391039008832202 no 1290 0.396739803092994 415 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_50 0929-0078 56.389 µM 0.260768743798049 0.391452874691301 no 1291 0.397135424757787 438 1377751
SGTC_1417 3966-0327 90.4 µM 0.260472215906249 0.391572497522528 no 1292 0.397249772163194 441 651118
SGTC_209 4077-0173 175.592 µM 0.260346877101074 0.391623063751076 no 1293 0.397298108104595 431 15993494
SGTC_577 r071-0003 38.6 µM 0.259449265513352 0.391985246349518 no 1294 0.397644311128102 429 4568517 YMR134W ERG29
SGTC_1405 3909-7894 12 µM 0.259194297477748 0.392088141993463 no 1295 0.397742665378191 433 7104060
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.258638372750058 0.392312518754727 no 1296 0.39795713659108 426 15053
SGTC_2218 6965428 192.983 µM 0.258480218025907 0.392376358123257 no 1297 0.398018157027531 415 675684
SGTC_2309 7664088 163.95 µM 0.256887344476489 0.393019484899866 no 1298 0.398632870235416 448 704922
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.256368510551464 0.3932290285818 no 1299 0.398833150228187 443 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2825 7998094 58.44 µM 0.256333222007904 0.393243281841476 no 1300 0.398846773261003 442 2987815
SGTC_989 1501-0895 10.3 µM 0.255449897917801 0.393600108445145 no 1301 0.399187817894046 458 2830112
SGTC_1648 st011736 69.8 µM 0.254283813285745 0.394071295501275 no 1302 0.399638152017715 426 2855514
SGTC_3025 9087895 49.47 µM 0.254142490016897 0.394128411422448 no 1303 0.399692739208587 421 17173641
SGTC_944 3370-0224 231 µM 0.252643854583775 0.394734226091925 no 1304 0.400271719009695 403 4580514
SGTC_1472 k841-0093 193 µM 0.251621730231513 0.395147560078524 no 1305 0.400666730317677 432 X1472
SGTC_3316 9136639 10.545 µM 0.249715423216458 0.395918761160736 no 1306 0.401403714998901 452 4903665
SGTC_303 1348-1668 34.2 µM 0.24785448879438 0.396671999861555 no 1307 0.40212349698731 426 5380509
SGTC_1793 st048256 72.231 µM 0.246486422116695 0.397225989787887 no 1308 0.402652856926349 457 672022
SGTC_1217 1183-1422 255 µM 0.246449853971515 0.397240800677457 no 1309 0.402667009064325 431 2849664
SGTC_580 1123-0028 41 µM 0.245064089204389 0.397802174396221 no 1310 0.403203403936538 457 1677248 YPR107C YTH1
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.244450472278194 0.398050818481836 no 1311 0.403440977953085 411 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_824 1304-0008 100 µM 0.244252131766646 0.398131197020759 no 1312 0.403517777058724 431 768245
SGTC_1339 1486-1321 22.7 µM 0.243129691844839 0.398586153086749 no 1313 0.403952465211391 430 3469382
SGTC_793 0488-0545 106 µM 0.242984836876325 0.398644876884007 no 1314 0.404008571958455 463 292548
SGTC_853 0419-0306 21 µM 0.239888547150364 0.399900650752053 no 1315 0.405208329856226 432 762713
SGTC_1101 ebselen 5.29 µM 0.237000650103888 0.401072840098096 no 1316 0.406328142957384 454 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1573 oleylamine 1.06 µM 0.236665663119177 0.40120886825712 no 1317 0.40645808755271 465 5356789 An amine of the fatty acid oleic acid.
SGTC_2329 6138490 200 µM 0.236305273483459 0.401355225042128 no 1318 0.406597897578285 438 720019
SGTC_68 0986-0284 82.829 µM 0.235983451126649 0.401485931081097 no 1319 0.406722755827703 406 423278 YIL048W NEO1
SGTC_2745 rifampicin 24.3 µM 0.234603268067943 0.402046608212291 no 1320 0.407258336394376 464 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1072 oxiconazole 14.9 nM 0.23460275834476 0.402046815316438 no 1321 0.407258534224752 439 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1819 st053448 58.6 µM 0.234031280421071 0.40227902814054 no 1322 0.40748034731134 452 2857616
SGTC_3173 9105693 49.47 µM 0.233323930474348 0.402566498601082 no 1323 0.407754938760345 440 17096658
SGTC_1737 st035557 69.7 µM 0.232443562573507 0.402924357986534 no 1324 0.408096758631505 457 5716916
SGTC_1029 k015-0030 64.7 µM 0.232297697047379 0.402983658500867 no 1325 0.408153400506611 423 2208316
SGTC_1386 3228-0095 33.8 µM 0.229351829475384 0.404181754272765 no 1326 0.409297736389781 456 870181
SGTC_1863 st057641 20.1 µM 0.227599482422567 0.404894867937873 no 1327 0.409978811180003 468 3921635
SGTC_2045 5106652 78.05 µM 0.225054188435363 0.405931231744616 no 1328 0.410968559541368 467 673349
SGTC_692 k241-0027 77.8 µM 0.223555488364773 0.406541764368411 no 1329 0.411551601083378 447 3600480
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.223537968828273 0.406548902732587 no 1330 0.411558417892738 445 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1909 st060837 51.5 µM 0.222895635974228 0.406810643741533 no 1331 0.411808366471962 445 678937
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.222448981592213 0.406992673253572 no 1332 0.411982192521052 469 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1425 4048-4433 7.33 µM 0.22233474543962 0.407039232279562 no 1333 0.412026652979304 477 23734946
SGTC_1345 1488-0192 31.4 µM 0.221986332869966 0.407181242283056 no 1334 0.412162261353738 453 658348
SGTC_205 1486-1330 71.903 µM 0.219987863928471 0.40799603642473 no 1335 0.412940303189965 441 4118834
SGTC_2755 lomerizine 42.69 µM 0.218587632736063 0.408567160906443 no 1336 0.413485643744462 426 3949 A calcium channel blocker.
SGTC_2278 7948257 134.34 µM 0.218504405754808 0.40860111354711 no 1337 0.413518062978002 458 1247028
SGTC_1207 2099-0101 141 µM 0.218332422164267 0.408671276826289 no 1338 0.413585057257309 455 5837381
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.217153064819605 0.409152492048981 no 1339 0.414044530361059 444 77254
SGTC_1703 st026983 48.3 µM 0.216884626051591 0.409262042743653 no 1340 0.414149129540843 439 1104023
SGTC_2678 equilin 100 µM 0.216501595387845 0.409418371015249 no 1341 0.414298390855102 436 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_176 1486-1328 72.834 µM 0.216206664015566 0.409538752688013 no 1342 0.414413329630822 418 22310231
SGTC_1964 st076914 61 µM 0.21576843028133 0.409717641609454 no 1343 0.414584128823862 468 24208661
SGTC_2565 isoliquiritigenin 100 µM 0.215007788012322 0.410028183705281 no 1344 0.414880623301239 423 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2540 epiandrosterone 100 µM 0.213789069622637 0.410525858909848 no 1345 0.415355774539607 454 441302 A steroid.
SGTC_1358 1509-0022 2.48 µM 0.212958922474302 0.410864939926503 no 1346 0.415679501414164 418 3258434
SGTC_1399 3562-5772 25 µM 0.212829861868303 0.410917661873586 no 1347 0.415729835452916 435 23847490
SGTC_1214 0358-0031 63.7 µM 0.211886791772554 0.411302959831537 no 1348 0.416097677642856 456 4301366
SGTC_2779 methotrexate 400 µM 0.211525594512141 0.411450552209331 no 1349 0.416238581239152 466 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3301 9125354 19.7965 µM 0.211214764026438 0.41157757375552 no 1350 0.416359845299913 422 41905162
SGTC_673 1082-0474 110 µM 0.210667087747837 0.411801405387319 no 1351 0.416573529195092 463 3098046
SGTC_2103 5378138 10 µM 0.210354381963485 0.411929219026839 no 1352 0.416695546983477 464 244142
SGTC_2405 ticlatone 3.52 µM 0.209916115535868 0.412108369353993 no 1353 0.416866572036631 375 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2429 5902844 64.44 µM 0.208900046569373 0.412523778637401 no 1354 0.417263133902843 463 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2927 9011802 47.9 µM 0.208293251280796 0.412771907383525 no 1355 0.417500000394062 432 43912568
SGTC_1567 st069303 68.4 µM 0.206474526901075 0.413515822646119 no 1356 0.418210130314794 462 5581319
SGTC_422 cantharidin 155 µM 0.205205962575907 0.414034889219617 no 1357 0.418705605556775 461 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_15 0266-0086 27.098 µM 0.205022343241744 0.414110034382265 no 1358 0.418777334212997 468 1712902 YIL048W NEO1
SGTC_347 4534-1311 26.2 µM 0.20481119266072 0.41419645043728 no 1359 0.418859820953332 429 2862016
SGTC_1772 st048439 82.2 µM 0.203742492242004 0.414633893284429 no 1360 0.41927736729425 464 2927068 YDL195W SEC31
SGTC_9 0092-0002 10.449 µM 0.203039589760937 0.414921664661657 no 1361 0.419552044236931 453 759368
SGTC_2229 7354935 190 µM 0.202958486043616 0.414954871822311 no 1362 0.419583740093292 465 318112
SGTC_875 0709-0210 25.7 µM 0.201784890423986 0.415435457501797 no 1363 0.420042447136434 465 6251364
SGTC_1854 st056233 32.9 µM 0.200533359468625 0.415948096991536 no 1364 0.420531735371003 459 5393174
SGTC_1984 st072354 53.1 µM 0.200477150932663 0.415971123928311 no 1365 0.420553713084539 460 5762938
SGTC_391 gliotoxin 8.33 µM 0.199099121554136 0.416535750920805 no 1366 0.421092604185881 446 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1493 4348-0038 111 µM 0.198590847443301 0.416744052205899 no 1367 0.421291406847556 476 800424
SGTC_532 1548-0774 215 µM 0.198574839730762 0.416750612878937 no 1368 0.42129766831475 469 5932993
SGTC_1463 k081-0032 34.1 µM 0.198008454643854 0.416982757605955 no 1369 0.421519224425196 451 977755
SGTC_1074 carmofur 3.8 µM 0.196850446695568 0.417457481302898 no 1370 0.42197228631626 459 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_886 0866-0150 153 µM 0.196147832651068 0.417745575624617 no 1371 0.422247229155852 468 271463
SGTC_2814 7977482 42.97 µM 0.195369770436181 0.41806465763128 no 1372 0.422551740145424 469 6456762
SGTC_742 0kpi-0133 140 µM 0.194840142662154 0.418281887958664 no 1373 0.422759047589852 473 2728852
SGTC_2746 daunorubicin 9.88 µM 0.193801638657438 0.418707909534794 no 1374 0.42316560193841 467 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_167 3672-0051 66.205 µM 0.19360762264012 0.418787510579487 no 1375 0.423241564563369 464 3237971
SGTC_1415 3966-0071 78.1 µM 0.191304124658595 0.419732844773529 no 1376 0.424143664880632 466 2893185
SGTC_2533 agelasine 13.65 µM 0.191075239886982 0.41982680235803 no 1377 0.42423332296864 471 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2 0422-0095 29 µM 0.190950428901579 0.419878039403787 no 1378 0.424282215223217 423 6790840
SGTC_3048 9093155 49.47 µM 0.190849757328217 0.419919367797295 no 1379 0.4243216521858 473 25236002
SGTC_2675 theaflavin digallate 100 µM 0.190278796555314 0.420153779274361 no 1380 0.424545334004591 469 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3196 9111891 49.47 µM 0.189992651689199 0.420271268479592 no 1381 0.424657444379265 476 18891510
SGTC_2916 7875993 68.79 µM 0.188482149754054 0.420891588162832 no 1382 0.425249353588397 468 1299250
SGTC_1603 st002045 67.8 µM 0.187569412091982 0.421266518583536 no 1383 0.425607103112897 459 5887985
SGTC_2838 9002687 71.43 µM 0.187451141395765 0.421315106540407 no 1384 0.425653464059983 463 6457060
SGTC_1148 3909-7663 27.7 µM 0.187403633777678 0.421334623953199 no 1385 0.425672086867365 457 4084526
SGTC_1149 3909-7961 23.3 µM 0.184003040786457 0.422732178655347 no 1386 0.427005534725595 465 735261
SGTC_58 0957-0393 9 µM 0.183254724861357 0.423039848155085 no 1387 0.427299078539681 450 6997992
SGTC_2417 cerulenin 830 nM 0.18251517058293 0.423343961434676 no 1388 0.427589224953553 489 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3135 9127742 49.47 µM 0.182433485690661 0.423377554012133 no 1389 0.42762127446994 475 3643468
SGTC_1269 0831-0796 3.05 µM 0.182028403696536 0.423544150548581 no 1390 0.427780217669485 471 927758
SGTC_1762 st045503 25.4615 µM 0.181985880948698 0.423561639511141 no 1391 0.427796903123833 453 4645554
SGTC_981 1488-1094 54.9 µM 0.18102031469967 0.423958802759962 no 1392 0.428175815301779 456 3449522
SGTC_1498 4478-3555 97.6 µM 0.18066994337991 0.424102938986051 no 1393 0.428313326105593 474 3437919
SGTC_1459 k035-0031 35.7 µM 0.179729908376701 0.424489701962422 no 1394 0.428682306140471 454 3877128 YMR208W ERG12
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.179006878467938 0.424787231018125 no 1395 0.428966150348487 464 5024745
SGTC_2899 9053889 58.44 µM 0.178345977898087 0.425059231151284 no 1396 0.429225636210868 480 6470052
SGTC_533 1222-0222 6.71 µM 0.178115146641879 0.425154240439966 no 1397 0.42931627346744 473 3982874
SGTC_1738 st035555 74 µM 0.177748428878201 0.42530518904787 no 1398 0.429460275025116 471 5331140
SGTC_348 k064-0012 10.7 µM 0.177145603200765 0.425553348336175 no 1399 0.429697011071743 450 5066323
SGTC_2426 5582046 32.21 µM 0.176833976484095 0.425681644196762 no 1400 0.42981940011138 441 2251934
SGTC_2788 5282734 71.43 µM 0.174426711910665 0.426672972543974 no 1401 0.430765061508639 464 743706
SGTC_249 wiskostatin 11.211 µM 0.173611843679385 0.427008646256878 no 1402 0.431085261734584 482 2775510 A n-wasp and actin depolymerizer.
SGTC_717 1532-0246 73.2 µM 0.172007876966286 0.42766953240186 no 1403 0.43171566818747 447 9561992
SGTC_849 0386-0493 241 µM 0.171054459607669 0.428062467493095 no 1404 0.432090471994893 464 726119
SGTC_2167 5876490 200 µM 0.170672294156412 0.428219990673287 no 1405 0.43224072460536 477 686534
SGTC_2508 celastrol 40.54 µM 0.170530044386484 0.428278626934016 no 1406 0.432296654193341 450 122724 Celastrol is a natural product and antioxidant.
SGTC_869 0564-0080 44.1 µM 0.169178687883765 0.428835743485234 no 1407 0.432828046376769 437 6843321
SGTC_1467 k284-1082 293 µM 0.168998119001954 0.428910196422044 no 1408 0.432899060469254 460 3334705
SGTC_84 0443-0269 128.823 µM 0.168504001877634 0.429113945841175 no 1409 0.433093397821807 492 6150058
SGTC_945 3381-0768 11.3 µM 0.168215659392052 0.429232852726061 no 1410 0.433206811035436 490 1126236 YIL048W NEO1
SGTC_664 1222-0054 14.9 µM 0.168056698919295 0.429298407708604 no 1411 0.433269337015457 455 6813991
SGTC_2766 oltipraz 83.91 µM 0.167913335603728 0.429357532126944 no 1412 0.433325729396386 446 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3 0833-0587 95.581 µM 0.167400955680232 0.429568855508727 no 1413 0.433527286631214 450 5382644
SGTC_1669 st015249 58.4 µM 0.166827459932349 0.429805409127142 no 1414 0.433752905780242 480 722793
SGTC_2667 digitoxin 100 µM 0.166509641937694 0.429936512494973 no 1415 0.43387794796205 467 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3047 9092122 49.47 µM 0.1651143889234 0.430512160706277 no 1416 0.434426973866806 461 17173831
SGTC_854 0422-0053 192 µM 0.164798207224148 0.430642630326711 no 1417 0.434551407588537 475 3596728
SGTC_185 k048-0037 25.491 µM 0.164664390346722 0.430697850975017 no 1418 0.434604073349358 480 6827589
SGTC_1394 3474-0001 65.7 µM 0.160670808089554 0.432346454914002 no 1419 0.436176341223455 458 5017666 YIL048W NEO1
SGTC_2811 7967822 32.47 µM 0.160310393904973 0.432495297099244 no 1420 0.436318285807447 458 2232244
SGTC_1715 st032160 10.2275 µM 0.159042200865551 0.433019105624921 no 1421 0.436817812734286 482 5289825
SGTC_2310 7668677 200 µM 0.157890503373051 0.433494899384752 no 1422 0.437271540704539 482 2197143
SGTC_810 3825-7150 143 µM 0.15778475859828 0.43353858992069 no 1423 0.437313204540651 454 22330411 YGL099W LSG1
SGTC_1466 k213-0079 57.5 µM 0.155799974319844 0.434358792734146 no 1424 0.438095345434098 489 3657981
SGTC_1687 st020778 55.3625 µM 0.155677505228949 0.434409411806799 no 1425 0.438143614595072 487 4259299
SGTC_1883 5-benzylidenerhodanine 20 µM 0.15445196933747 0.434916010870429 no 1426 0.438626689806657 477 1273210
SGTC_400 oxethazaine 37.5 µM 0.154171516071462 0.435031956730644 no 1427 0.438737250265271 472 4621 A local anesthetic.
SGTC_2552 juarezic acid 87.02 µM 0.15408018859632 0.435069714825367 no 1428 0.43877325447081 442 1549512
SGTC_2290 7904846 200 µM 0.153084357553446 0.435481465895826 no 1429 0.439165875669753 453 2962154
SGTC_1432 4049-0298 68.4 µM 0.15293446098717 0.435543450421539 no 1430 0.439224979812802 494 741646
SGTC_1965 Pectolinarigenin 58.4 µM 0.152218549817994 0.435839512470717 no 1431 0.439507281904524 454 5320438 An anti-inflammatory.
SGTC_1501 4491-0275 38.4 µM 0.151903611961616 0.435969765093668 no 1432 0.439631479711808 490 5104718
SGTC_2467 5474540 200 µM 0.151728775384085 0.436042077350862 no 1433 0.439700430227412 477 5413519
SGTC_1919 st067113 52.3 µM 0.151417615007484 0.436170778300427 no 1434 0.439823147450061 475 1268243
SGTC_612 0302-0167 22.4 µM 0.150931547471818 0.436371837191571 no 1435 0.440014857132428 467 235821
SGTC_2911 7942208 15.64 µM 0.150079728335995 0.436724226638557 no 1436 0.440350856637219 460 1243384
SGTC_3039 9090270 49.47 µM 0.149361744129317 0.437021288867237 no 1437 0.440634098414306 485 17173750
SGTC_3058 9093861 49.47 µM 0.148775848627683 0.437263726403429 no 1438 0.440865254262052 483 17217477
SGTC_1794 st048918 76.9 µM 0.14857719307723 0.437345933380929 no 1439 0.440943635260715 479 672303
SGTC_2072 5231554 129 µM 0.14524619235383 0.438724757194349 no 1440 0.442258248184962 492 789545
SGTC_460 trequinsin 123 µM 0.143032473594772 0.439641509444124 no 1441 0.443132267320796 486 5537 A vasodilator.
SGTC_2420 aureobasidin a 50 nM 0.142994000141417 0.43965744506944 no 1442 0.443147459846152 434 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1719 st032227 49.2 µM 0.142962658147253 0.439670426931284 no 1443 0.443159836338938 484 3125804
SGTC_1713 st033146 12.748 µM 0.14252063825736 0.43985351858303 no 1444 0.443334389396562 476 674619
SGTC_3004 9076122 71.4286 µM 0.141682053725587 0.440200908923573 no 1445 0.443665575489294 487 44782551
SGTC_2037 5169046 200 µM 0.140806023652221 0.440563860542491 no 1446 0.444011592146772 455 5718022
SGTC_2780 5215298 71.43 µM 0.140583430212533 0.440656092113995 no 1447 0.444099519498834 484 2834131
SGTC_1220 1838-0075 193 µM 0.139787754144492 0.440985806708353 no 1448 0.444413844533929 481 5529645
SGTC_2515 chrysin 20.77 µM 0.139624373650685 0.4410535138691 no 1449 0.444478390935665 465 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_906 1165-0455 526 µM 0.13905136505177 0.441290990248708 no 1450 0.444704779912419 494 3252859
SGTC_2890 9046729 58.44 µM 0.137251473996868 0.442037069904265 no 1451 0.445416012742047 473 903329
SGTC_675 1309-0189 238 µM 0.135955986860089 0.442574194624017 no 1452 0.445928037602475 447 4246530
SGTC_1682 st012968 530 nM 0.135873693683148 0.442608317952339 no 1453 0.445960565992399 459 24207270
SGTC_358 0075-0058 9.45 µM 0.135640625620118 0.442704963244215 no 1454 0.446052693814948 491 1069125
SGTC_2470 5664817 21.68 µM 0.135142284291874 0.442911619646678 no 1455 0.446249689391399 488 2859561
SGTC_510 ag-490 170 µM 0.134409454343839 0.443215543974011 no 1456 0.446539402994018 487 5328779
SGTC_2257 7960413 200 µM 0.134263208766164 0.443276199960767 no 1457 0.446597222465076 485 2974689 YIL048W NEO1
SGTC_1670 st016595 4.04 µM 0.132604771029068 0.44396413686026 no 1458 0.447252979505668 495 597879
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.131990328762884 0.444219056769611 no 1459 0.447495970675021 504 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1304 1165-0502 251 µM 0.131897262868084 0.444257669978566 no 1460 0.447532776814772 477 767425
SGTC_1209 2323-2347 50.3 µM 0.129812866482595 0.445122627780304 no 1461 0.448357241536694 482 5412760
SGTC_836 0330-0104 1.35 µM 0.128585468707626 0.44563208109667 no 1462 0.448842832567757 483 46494820
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.128578118883108 0.445635132043565 no 1463 0.448845740584351 465 4330530
SGTC_1765 st044815 90.4 µM 0.128120552631111 0.445825076289234 no 1464 0.449026785720209 494 645695
SGTC_1414 3917-0015 5.4 µM 0.12641876176203 0.446531630053716 no 1465 0.449700225779599 503 6618702
SGTC_3234 9132280 49.47 µM 0.126401302960867 0.446538879525842 no 1466 0.449707135406241 451 17612295
SGTC_976 1348-1067 47.6 µM 0.126294866482239 0.446583075861212 no 1467 0.449749259838434 468 5310671 YGL099W LSG1
SGTC_816 0325-0417 81.3 µM 0.126280095031554 0.446589209562541 no 1468 0.449755105989533 507 68101
SGTC_818 4072-2707 53.5 µM 0.12595129195595 0.446725745149215 no 1469 0.449885240406827 471 882871
SGTC_601 0986-0029 62.9 µM 0.125593751090288 0.446874221279748 no 1470 0.450026754847077 489 24747981
SGTC_2061 5245884 80.95 µM 0.124814253016749 0.447197949527784 no 1471 0.450335301679251 491 573863
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.124692355874402 0.447248577019525 no 1472 0.450383554648576 473 115019
SGTC_1175 0741-0056 27.6 µM 0.123650555112106 0.447681302699404 no 1473 0.450795981204679 481 765927
SGTC_2973 9094665 17.96 µM 0.122899217261784 0.447993419462046 no 1474 0.451093452731645 512 25237061 YIL048W NEO1
SGTC_3082 9117008 49.47 µM 0.122898814648394 0.447993586722203 no 1475 0.451093612142706 486 41448529
SGTC_1547 harmine 94.2 µM 0.121296746156534 0.448659216799401 no 1476 0.451727998590684 488 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2440 5628896 157.78 µM 0.120314607572791 0.449067348958392 no 1477 0.452116966499571 502 5522048
SGTC_1999 st074831 12.5 µM 0.119520068465851 0.449397562759906 no 1478 0.452431670829767 488 17112523
SGTC_1646 st011709 75.6 µM 0.118996489495195 0.449615183558659 no 1479 0.452639068498899 504 5757843
SGTC_1145 3546-0597 10.2 µM 0.118666177670369 0.449752482440529 no 1480 0.452769916735371 478 875334
SGTC_2581 avocatin a 64 µM 0.118659746396967 0.449755155751983 no 1481 0.452772464441958 484 6710728 A skin care supplement.
SGTC_2475 5812728 15.03 µM 0.118171847299389 0.449957969233056 no 1482 0.452965748116055 479 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1379 2144-0755 36.5 µM 0.117927909847684 0.450059375849633 no 1483 0.453062389342444 501 5392327
SGTC_74 000s-0487 160.283 µM 0.117684952821307 0.450160378137391 no 1484 0.453158644915008 466 677548
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.116665841907274 0.450584078831206 no 1485 0.453562429794847 505 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3206 9114350 49.47 µM 0.116590984233995 0.45061520352682 no 1486 0.453592091267726 498 17087243
SGTC_2335 9018011 154.17 µM 0.116096932557066 0.450820630397333 no 1487 0.453787859920545 497 6458208
SGTC_1625 st003711 30.1 µM 0.11576579579256 0.450958324564339 no 1488 0.453919079604782 490 24207034 YER133W GLC7
SGTC_840 0245-0196 390 µM 0.115027247307854 0.451265450989229 no 1489 0.454211762577411 480 3827528
SGTC_2634 4'-methoxyflavone 100 µM 0.114846881643415 0.451340460743896 no 1490 0.454283244348001 481 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_233 rapamycin 362 pM 0.11440015733107 0.451526250148204 no 1491 0.454460294641525 498 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2401 5128683 200 µM 0.113852803305452 0.451753905192222 no 1492 0.4546772398517 491 708373
SGTC_376 3970-0862 59.1 µM 0.113222627495998 0.452016027050358 no 1493 0.454927028433464 492 3135186
SGTC_3265 9137266 49.47 µM 0.112772240350624 0.452203378572219 no 1494 0.45510556345559 490 17224265
SGTC_1838 st055369 84.5 µM 0.112632238360891 0.45226161860782 no 1495 0.45516106257774 460 676036
SGTC_3081 9117243 49.47 µM 0.112297675886909 0.452400798862142 no 1496 0.455293692261123 485 45595589
SGTC_1702 st027038 51 µM 0.112129055030085 0.452470948498187 no 1497 0.455360540054191 473 5521182
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.111514506532482 0.452726625458301 no 1498 0.455604181398577 480 16486 A toxic proline analog.
SGTC_3281 9140613 49.47 µM 0.111309894785015 0.452811756552188 no 1499 0.455685304631648 475 16013766
SGTC_143 4032-1194 15.74 µM 0.110511256635727 0.453144059949387 no 1500 0.456001961523097 471 1806963
SGTC_1051 3253-3903 78 µM 0.109379264724712 0.453615123862958 no 1501 0.456450839707571 504 5509239
SGTC_2064 5220758 200 µM 0.108274868919384 0.454074766917954 no 1502 0.456888828548729 488 788518
SGTC_3189 9110682 49.47 µM 0.108201021160087 0.454105504123103 no 1503 0.456918117472242 497 17122418
SGTC_3010 9080089 71.4286 µM 0.107697081847462 0.454315263056337 no 1504 0.45711799219955 478 17027233
SGTC_625 k213-0058 121 µM 0.104396210077205 0.455689525318763 no 1505 0.45842746508503 505 3655420
SGTC_3240 9133527 49.47 µM 0.103678303013392 0.455988484593209 no 1506 0.458712322766779 499 17617455
SGTC_3059 1327-0034 3 µM 0.103433051922995 0.456090620646078 no 1507 0.458809640587004 480 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2345 9052315 157.45 µM 0.103319066738096 0.456138091338972 no 1508 0.458854871765753 484 6469265
SGTC_3118 9124250 49.47 µM 0.1030207608708 0.456262327868527 no 1509 0.458973246914491 507 1504786
SGTC_2770 toltrazuril 17.5 µM 0.10236615518755 0.456534968848782 no 1510 0.459233023381777 497 68591 Kills coccidiodes.
SGTC_833 3852-0053 558 µM 0.101928048030163 0.456717450388105 no 1511 0.459406893396066 482 3123681
SGTC_941 3237-0776 460 µM 0.101896573995099 0.456730560387419 no 1512 0.459419384682668 514 760008
SGTC_501 nsc-95397 161 µM 0.101552620164056 0.456873831848981 no 1513 0.459555894283972 502 262093
SGTC_1647 st011722 22.4 µM 0.101312951036211 0.456973667592677 no 1514 0.459651017826803 482 2854783
SGTC_313 3474-0040 5.03 µM 0.10109961426757 0.457062536704523 no 1515 0.459735692124084 502 1043375 YIL048W NEO1
SGTC_2029 5175081 200 µM 0.100943475433473 0.457127580391015 no 1516 0.459797665468459 492 1380876
SGTC_852 0418-0143 439 µM 0.100386124187761 0.457359768882467 no 1517 0.460018892705888 499 5369229
SGTC_1291 0993-0025 5.79 µM 0.100001881113641 0.457519850244754 no 1518 0.460171416010189 495 4353356
SGTC_1356 1502-0781 85.8 µM 0.0994205485189649 0.457762055117159 no 1519 0.460402184115883 484 567702
SGTC_1995 st072814 61.1 µM 0.0984194957080574 0.458179167822397 no 1520 0.460799597248587 477 5769371
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.097971456184606 0.458365869202449 no 1521 0.460977479484132 493 279621
SGTC_158 k038-0087 26.446 µM 0.0965918256265166 0.458940828963275 no 1522 0.461525274172339 463 X158
SGTC_2443 5493264 126.67 µM 0.0956512967018174 0.459332842839253 no 1523 0.461898761530067 498 5340055
SGTC_2768 sulfasalazine 50.2 µM 0.0946925971637686 0.459732470949922 no 1524 0.462279499081863 503 5384001 An antioxidant and salicylic acid derivative.
SGTC_1519 esterone 74 µM 0.0940998197797012 0.459979587002866 no 1525 0.46251493177121 482 698 A steroid.
SGTC_2809 7964133 12.99 µM 0.0939770748598291 0.460030758636751 no 1526 0.462563683869152 500 1253665
SGTC_992 3909-8734 162 µM 0.0936834613874315 0.460153167047756 no 1527 0.462680304195739 494 4288319
SGTC_1085 doxorubicin 7.67 µM 0.0933014626489608 0.460312429214819 no 1528 0.462832035063815 505 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1871 st057448 67.3 µM 0.0931617346354919 0.460370685936768 no 1529 0.462887536737266 506 691747
SGTC_2519 cryptotanshinone 88.04 µM 0.0911938532185079 0.461191243407084 no 1530 0.463669279512228 506 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2719 novobiocin 32.65 µM 0.0901923537796297 0.461608907366135 no 1531 0.464067180181985 487 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_357 1325-0123 420 µM 0.0899779560223359 0.461698325032587 no 1532 0.464152366153448 510 1098503
SGTC_393 acivicin 6.25 µM 0.0891924130276099 0.46202596353853 no 1533 0.464464497437129 504 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2490 carminic acid 95.39 µM 0.0864270946239727 0.463179541000761 no 1534 0.465563454557337 508 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_841 0251-0215 91.2 µM 0.0854864592359649 0.463572006594808 no 1535 0.465937330013878 517 3888614
SGTC_441 propafenone 146 µM 0.0852372613343897 0.463675986528376 no 1536 0.466036384048635 517 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2097 5376186 200 µM 0.0849367688271424 0.463801372869725 no 1537 0.466155830048155 486 742755
SGTC_914 3820-6779 408 µM 0.0844519955198605 0.464003661532028 no 1538 0.466348534227183 510 2893481
SGTC_3017 9080681 49.47 µM 0.0844264013655065 0.464014341849545 no 1539 0.466358708481649 508 16451914
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0840863675959089 0.46415623876412 no 1540 0.466493881669316 475 16623 A steroid.
SGTC_1189 1431-2119 7.28 µM 0.0834141283783036 0.464436779215175 no 1541 0.466761127420591 523 3107275
SGTC_286 k060-0067 22.9 µM 0.0822346026994746 0.464929064289639 no 1542 0.467230078821844 493 5985051
SGTC_3351 9150312 21.596 µM 0.0819132696887803 0.465063184690928 no 1543 0.467357841108129 514 4904905
SGTC_375 3970-0961 9.27 µM 0.0810563084802803 0.465420889004925 no 1544 0.467698586042466 504 2898222
SGTC_2772 vinpocetine 57.06 µM 0.0806237542809268 0.465601452151294 no 1545 0.467870587257108 521 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.0803659170023218 0.46570908575787 no 1546 0.467973116744351 501 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1252 0493-0875 34.8 µM 0.0797572569543334 0.465963179496302 no 1547 0.46821515999236 502 3960963
SGTC_1859 st055998 20 µM 0.0788187648803158 0.466354993430331 no 1548 0.468588389132071 484 676301
SGTC_362 0310-0100 9.03 µM 0.0778424270422704 0.466762642312882 no 1549 0.468976698459734 506 790235
SGTC_2521 angolensin 13.4 µM 0.0778175406605463 0.466773033544279 no 1550 0.468986596664944 514 821428 A flavenoid.
SGTC_2130 NSC 7 2.4545 µM 0.0776787036728422 0.466831004912702 no 1551 0.469041817458396 521 21448
SGTC_448 monastrol 171 µM 0.0776224507781861 0.46685449350284 no 1552 0.469064191561104 511 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_367 0335-0881 7.1 µM 0.0770304413852643 0.467101696050338 no 1553 0.469299664091719 519 23828853
SGTC_2931 9014674 55.67 µM 0.0755907858095088 0.467702898946712 no 1554 0.469872333674782 513 2996810
SGTC_2947 9072639 7.68 µM 0.0750155687783706 0.46794313134554 no 1555 0.470101162350794 495 16488146
SGTC_374 0880-0231 82.3 µM 0.0738835599322002 0.468415935089824 no 1556 0.47055151868277 517 6833587
SGTC_2094 5332512 191.667 µM 0.0700586177928614 0.470013816292476 no 1557 0.472073501974803 515 755774
SGTC_789 1309-1135 70.6 µM 0.0693557847732054 0.470307480212496 no 1558 0.472353211383332 510 3092424
SGTC_3204 9114183 49.47 µM 0.0691039475107395 0.47041270902734 no 1559 0.472453439441593 506 17027248
SGTC_2274 7947094 46.08 µM 0.068189352195033 0.470794884972173 no 1560 0.472817451480265 529 2971028
SGTC_2765 myclobutanil 7.74 µM 0.0678476224691927 0.470937688252907 no 1561 0.472953466912818 513 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2293 7624732 200 µM 0.0664318201784956 0.471529368557179 no 1562 0.473517018654846 520 894453
SGTC_3326 9140064 16.379 µM 0.0660079866018388 0.471706505838177 no 1563 0.473685733467742 510 1868434
SGTC_2714 st079313 56.9 µM 0.0657762295594744 0.471803368896627 no 1564 0.47377799065323 515 2939799
SGTC_3307 9126885 69.2785 µM 0.0653828030254597 0.471967805676179 no 1565 0.473934607988549 497 24824909
SGTC_2201 6605497 169.863 µM 0.0651926478773849 0.472047284745433 no 1566 0.474010307410889 517 670741
SGTC_1223 0764-0573 147 µM 0.0650659924544596 0.472100223478416 no 1567 0.474060728561685 516 1609797
SGTC_451 chloral hydrate 100 µM 0.0646694393357648 0.472265975740339 no 1568 0.474218597873612 524 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1704 st028805 70.8 µM 0.0640500158779444 0.472524893502834 no 1569 0.474465200811016 515 2876101
SGTC_2341 7987486 176.74 µM 0.0603686457396545 0.474063934672195 no 1570 0.475931015085689 524 1258686
SGTC_490 phenamil 164 µM 0.0587929442504865 0.474722795340074 no 1571 0.476558514206681 529 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_463 ikarugamyin 104 µM 0.0581527861321479 0.474990489625956 no 1572 0.476813464122558 530 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_729 4092-0585 94.1 µM 0.0579237446615379 0.475086270419506 no 1573 0.476904684683994 503 2169061
SGTC_3252 9135871 49.47 µM 0.0577231965298755 0.475170137022277 no 1574 0.47698455817051 515 17682838
SGTC_433 pimozide 108 µM 0.0576664933621434 0.475193849744243 no 1575 0.477007141843171 504 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1383 3049-0032 20.7 µM 0.057107692170573 0.475427539740008 no 1576 0.477229704479676 530 712864
SGTC_3315 9136395 68.55 µM 0.0570901366661194 0.475434881568532 no 1577 0.477236696705033 531 16876844
SGTC_55 0767-0285 6.563 µM 0.0566445125091017 0.47562124733598 no 1578 0.477414187795256 521 3116166
SGTC_2155 5570423 76 µM 0.055944922810052 0.475913835510867 no 1579 0.477692841808907 511 797402
SGTC_2897 9048598 12.99 µM 0.0548919671689601 0.476354235739973 no 1580 0.478112265751156 524 6467404
SGTC_1705 st027868 56.3335 µM 0.0527216447028419 0.477262066797556 no 1581 0.478976846514087 529 292948
SGTC_3108 9121785 49.47 µM 0.0525028211054581 0.47735360584065 no 1582 0.479064023759967 525 17140271
SGTC_2957 9076800 11.52 µM 0.0515244515913692 0.477762895301324 no 1583 0.479453809086497 520 16459615
SGTC_2398 5228213 48.84 µM 0.050362771080755 0.478248901200984 no 1584 0.479916651546362 525 80771 YMR134W ERG29
SGTC_3339 9145883 14.936 µM 0.0498827971422847 0.478449714748058 no 1585 0.480107893063723 534 2030670
SGTC_1882 5615643 20 µM 0.0498520807358549 0.478462566196225 no 1586 0.480120131909939 523 2253075
SGTC_80 0159-0065 512.242 µM 0.0497110255395904 0.47852158261709 no 1587 0.480176335106922 525 1548079
SGTC_2878 9043973 25.97 µM 0.049595586696471 0.478569881701189 no 1588 0.480222331805955 510 6465167
SGTC_2518 prenyletin 46.28 µM 0.0478614437802068 0.479295476643858 no 1589 0.480913333780739 531 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_808 0711-0032 135 µM 0.0477065905308717 0.479360273254619 no 1590 0.480975040800667 534 4252555
SGTC_2690 usnic acid 100 µM 0.0469342313323716 0.479683466436589 no 1591 0.481282822744045 520 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2967 9089538 49.85 µM 0.046578207806628 0.479832448749627 no 1592 0.481424700413231 532 728216
SGTC_2663 amphotericin b 100 µM 0.0453990590289048 0.480325897697427 no 1593 0.481894615501026 522 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1565 sinapyl alcohol 95.1 µM 0.0450698039344322 0.480463689442399 no 1594 0.482025834962361 533 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2056 5235370 200 µM 0.0445009820458951 0.480701744281151 no 1595 0.482252534597334 508 5511916
SGTC_1897 st060201 15 µM 0.0428774686438817 0.48138123042211 no 1596 0.482899604823287 506 611878
SGTC_3199 9111318 49.47 µM 0.0421426903920819 0.481688773740652 no 1597 0.483192474185364 524 8548020
SGTC_53 0973-0023 39.979 µM 0.041987428915949 0.481753760229806 no 1598 0.483254359776096 529 674768
SGTC_1253 0550-0034 176 µM 0.0403223057270882 0.482450746958569 no 1599 0.483918085419797 524 5969915
SGTC_1529 apigenin 74 µM 0.0400405898142071 0.482568672878223 no 1600 0.484030383116482 531 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1830 st055982 50.3 µM 0.0395895739137589 0.482757470726345 no 1601 0.48421016986765 524 455313 An antimicrobial agent.
SGTC_2639 lactacystin 53 µM 0.039239129411073 0.482904171480898 no 1602 0.484349868443589 512 3870 A proteasome inhibitor.
SGTC_644 1498-1197 63.3 µM 0.0389634555870531 0.483019573857119 no 1603 0.484459762346122 522 6741615
SGTC_2887 9044784 58.44 µM 0.0380104490042951 0.483418531680275 no 1604 0.484839675474592 535 6465546
SGTC_2360 9040895 200 µM 0.0378914372828926 0.483468354816104 no 1605 0.484887120103155 520 4914414
SGTC_1841 st054148 70 µM 0.0377014897572893 0.483547875092468 no 1606 0.484962844094129 521 675442
SGTC_878 0828-0289 13.7 µM 0.0373187503724231 0.48370810839126 no 1607 0.485115427635213 527 745350 YLR208W SEC13
SGTC_2153 5569715 200 µM 0.0372056179476892 0.483755471624847 no 1608 0.485160529620443 531 2054701
SGTC_156 3474-0145 5.642 µM 0.0371746105475387 0.483768453007247 no 1609 0.485172891231711 524 2265471
SGTC_2282 7944268 200 µM 0.0349904777892419 0.484682892137173 no 1610 0.486043666924288 522 2970414
SGTC_542 3381-0244 89.3 µM 0.0348555227304464 0.484739396974517 no 1611 0.486097473381542 538 1112843
SGTC_3013 9080133 71.4286 µM 0.0326485296520918 0.485663493804745 no 1612 0.486977434686149 533 17050193
SGTC_1523 st012844 44.7 µM 0.0326303492838891 0.485671106488941 no 1613 0.486984683741341 520 4274103
SGTC_2926 9010726 65.15 µM 0.032597617396318 0.485684812358906 no 1614 0.486997734932271 520 2994293
SGTC_370 0180-0345 38.7 µM 0.0313681090187326 0.486199658260579 no 1615 0.487487986972928 519 3989527
SGTC_458 nppb 133 µM 0.0311939931567843 0.486272569637338 no 1616 0.487557415175657 529 4549 A chloride channel blocker.
SGTC_2488 5268135 45.7 µM 0.0309654149654119 0.486368287923268 no 1617 0.487648560648849 529 1270356 YLR208W SEC13
SGTC_2868 9035608 32.47 µM 0.030912867537682 0.48639029253843 no 1618 0.487669514008497 533 6462614
SGTC_2750 bromebric acid 70.15 µM 0.0299256222178771 0.486803716280406 no 1619 0.488063185711366 526 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1680 diphenhydramine 100 µM 0.0298637794803297 0.486829614328268 no 1620 0.488087846372111 534 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_3217 9129673 49.47 µM 0.0298132933900393 0.486850756563906 no 1621 0.488107978443926 522 17248312
SGTC_2070 5230947 200 µM 0.0292633113401945 0.48708107684146 no 1622 0.488327293835856 535 2835538
SGTC_628 1636-0253 16 µM 0.0287567364351876 0.487293222984154 no 1623 0.488529302960038 529 4456143
SGTC_1457 k015-0032 57.3 µM 0.0278556407657454 0.487670597486661 no 1624 0.48888864412096 532 4302660
SGTC_603 3794-0023 45.9 µM 0.0274381283519543 0.487845453426662 no 1625 0.489055143829999 531 3802260
SGTC_569 4130-2812 160 µM 0.0273395631900907 0.487886733269631 no 1626 0.489094450894585 533 743552
SGTC_2817 7995342 71.43 µM 0.0264415281919777 0.488262843111631 no 1627 0.489452585505344 534 18879975
SGTC_1446 4239-0190 62 µM 0.0257575193069884 0.488549322791546 no 1628 0.489725372639326 540 1340085
SGTC_2835 9006588 71.43 µM 0.0246035716942036 0.489032637638965 no 1629 0.490185585181625 533 2345538
SGTC_2009 4012297 12.05 µM 0.02347092253739 0.489507047592099 no 1630 0.490637316273463 530 45595307
SGTC_2546 rhodinyl acetate 100 µM 0.0232744457809729 0.489589343385946 no 1631 0.490715677751917 528 6708682
SGTC_3282 9108498 15.4605 µM 0.0230758048962943 0.489672546092037 no 1632 0.490794902721117 535 16459645
SGTC_2337 9009472 200 µM 0.0222161017293633 0.490032646431375 no 1633 0.491137786718993 537 5742383
SGTC_3023 9089636 49.47 µM 0.0200365265853966 0.490945631868504 no 1634 0.492007117203258 544 17249241
SGTC_718 1130-0073 349 µM 0.0184920286382614 0.491592623712492 no 1635 0.492623168352428 537 6740020
SGTC_244 nsc-207895 1.295 µM 0.0183128115046081 0.491667699426423 no 1636 0.492694653539099 539 42640
SGTC_911 3456-4043 236 µM 0.0179624494118286 0.491814470195884 no 1637 0.492834404801512 540 914281
SGTC_2669 eugenol 100 µM 0.0162175418650893 0.492545448441735 no 1638 0.493530420459657 541 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1248 0469-0687 58.6 µM 0.0151682048624694 0.492985049857877 no 1639 0.493948993793769 545 4017482
SGTC_889 0919-1524 82.7 µM 0.0139661819862422 0.493488626792418 no 1640 0.494428480635241 533 3905452
SGTC_2658 polymyxin b sulfate 77.05 µM 0.0138315011229621 0.493545050819351 no 1641 0.494482205336464 541 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2028 5153890 36.43 µM 0.0130427948964945 0.493875478799347 no 1642 0.494796825184182 538 2830968 YPR165W RHO1
SGTC_998 3996-0085 177 µM 0.0128857678659061 0.493941265684371 no 1643 0.494859464641576 543 715391
SGTC_2427 5545055 42.75 µM 0.0121170112579543 0.494263340619807 no 1644 0.495166130183766 538 5372858
SGTC_2003 4023581 200 µM 0.0119860656507344 0.4943182014022 no 1645 0.495218366129381 541 16641307
SGTC_1367 1812-0510 76.9 µM 0.0118795911912311 0.494362809867166 no 1646 0.495260840268935 539 1142582 YDR527W RBA50
SGTC_148 3253-0744 288.01 µM 0.0109936116098626 0.494734001932831 no 1647 0.495614271857507 538 6893655
SGTC_3179 9107801 49.47 µM 0.0105801312953216 0.494907236186934 no 1648 0.495779217039407 538 4818259
SGTC_1385 3091-4834 14.1 µM 0.00971910934068503 0.49526797828187 no 1649 0.496122697398622 543 4072814
SGTC_3305 9127027 53.8275 µM 0.0091333928600018 0.495513377959256 no 1650 0.496356354082834 535 41905295
SGTC_807 1315-0151 48 µM 0.00873363179655632 0.495680868227185 no 1651 0.496515829308241 545 4011080
SGTC_1213 1315-0166 115 µM 0.00836811665494173 0.495834010944833 no 1652 0.49666164342067 544 768401
SGTC_3054 9094397 49.47 µM 0.00828282594978156 0.495869745943155 no 1653 0.496695668309862 541 2598354
SGTC_1866 st057638 64 µM 0.00760747611373284 0.496152704361976 no 1654 0.496965085404735 543 688802
SGTC_974 1326-0144 138 µM 0.00743878291725413 0.496223383831171 no 1655 0.497032382348701 539 5411856
SGTC_2261 9010538 184.68 µM 0.00678242699279225 0.496498386475967 no 1656 0.497294223853732 545 6457250
SGTC_517 1365-0151 113 µM 0.00674888352039146 0.496512440700732 no 1657 0.497307605456835 539 768657
SGTC_2627 acetyl isogambogic acid 100 µM 0.00598791032996786 0.496831278476504 no 1658 0.497611183673328 542 6857789 A caspase activator and apoptosis inducer.
SGTC_1295 1013-0063 9.78 µM 0.0058069138961529 0.496907113911503 no 1659 0.497683389547628 541 6826038
SGTC_1594 piperine 70.1 µM 0.00540914579579733 0.497073774583573 no 1660 0.497842073564283 545 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3237 9133362 49.47 µM 0.00412824269162687 0.497610462905706 no 1661 0.498353074124478 540 43845137
SGTC_1167 k781-0610 148 µM 0.00344670775503276 0.497896022506055 no 1662 0.498624965270852 544 4525169
SGTC_1280 0880-0253 10.1 µM 0.00316094239306044 0.498015757038408 no 1663 0.49873896853344 545 6836607
SGTC_2150 5556613 200 µM 0.00266522046516023 0.498223462941493 no 1664 0.498936732128659 547 743190
SGTC_1898 st060199 18.6 µM 0.00257944010017708 0.498259404690652 no 1665 0.498970953425405 542 688866
SGTC_1818 st052136 56.3 µM 0.00227586023911041 0.498386603972005 no 1666 0.499092063910116 546 674169
SGTC_2650 prasterone 100 µM 0.00204552594333185 0.498483113635799 no 1667 0.499183953784627 546 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_228 caffeine 993.056 µM 0.00189300885400842 0.498547018076502 no 1668 0.499244799182003 546 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_933 2914-0560 114 µM 0.000988031416524136 0.498926203030511 no 1669 0.499605832557715 543 463887
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.000290721435884891 0.499218376135601 no 1670 0.49988401892904 548 6708760
SGTC_2307 7538926 6.34 µM 0.000121850581500958 0.499289133146655 no 1671 0.499951388651268 548 96582
SGTC_3273 9137859 49.47 µM -0.000174050117386781 0.499413115807705 no 1672 0.499930564049616 549 2377234
SGTC_2233 sulbentine 40.3845 µM -0.000298650948713822 0.499465323686625 no 1673 0.499880855511247 547 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_654 1124-0271 80.9 µM -0.000425312227121166 0.499518394904411 no 1674 0.499830324975345 548 5403748
SGTC_1971 st069429 63.5 µM -0.000567307986343102 0.499577891296955 no 1675 0.499773676870378 548 1246522 YGL099W LSG1
SGTC_748 act1.228 77.9 µM -0.000720962591865072 0.499642272770545 no 1676 0.499712377564434 548 4421505 YNR035C ARC35
SGTC_2679 rapamycin 1 nM -0.0012425768449949 0.499860829860275 no 1677 0.499504283687448 550 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1108 betulinic acid 729.144 nM -0.00141654454833291 0.499933722579858 no 1678 0.499434880676592 548 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1089 terbinafine 2.25 µM -0.00173290344634344 0.499933722579858 no 1679 0.499308671893405 550 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1376 2910-0861 41.3 µM -0.0020991739575511 0.499780254710852 no 1680 0.499162551369456 550 1112859
SGTC_2208 7283366 200 µM -0.00235891821252774 0.499671421514216 no 1681 0.499058928661778 550 898663
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.00384609108166516 0.499048294772814 no 1682 0.498465635436076 553 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1336 1486-0901 104 µM -0.00423390206943877 0.498885801947629 no 1683 0.498310922499803 548 5006114
SGTC_2827 7993847 71.43 µM -0.0045008564783958 0.498773948141397 no 1684 0.498204424115127 552 2985692
SGTC_2482 5981709 142.65 µM -0.0054526740505646 0.498375137749193 no 1685 0.497824708559156 552 877755
SGTC_1941 st076221 61.8 µM -0.00629085136628107 0.498023943816123 no 1686 0.497490329963566 558 2828568
SGTC_2010 4012422 159 µM -0.00672118964245011 0.497843633869024 no 1687 0.497318653465078 553 952393
SGTC_1816 st051957 91.6 µM -0.00738693854944456 0.497564688728242 no 1688 0.497053064690759 552 674121
SGTC_1968 st069590 43.6 µM -0.00755103712466667 0.497495932502857 no 1689 0.496987600657029 551 6384066
SGTC_2393 9031399 185.94 µM -0.0076372624128525 0.497459804703027 no 1690 0.49695320273584 556 1526623 YDL150W RPC53
SGTC_2970 9090938 41.86 µM -0.00792765322439586 0.497338133114882 no 1691 0.496837357071927 559 17217104
SGTC_1022 4477-0945 21.3 µM -0.00888285890042513 0.496937910855604 no 1692 0.496456298616575 556 4648966
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.0104273177899031 0.496290803697119 no 1693 0.495840177444756 554 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_723 4182-0001 115 µM -0.0109346652415243 0.49607823409787 no 1694 0.495637786642684 556 744821 YLR208W SEC13
SGTC_3134 9127454 49.47 µM -0.0115912544675376 0.495803136499371 no 1695 0.495375862057928 552 24262820
SGTC_1643 st009866 20.2 µM -0.0119879140010579 0.49563694514057 no 1696 0.495217628797262 554 3156273 YOR207C RET1
SGTC_1039 k821-0043 94 µM -0.0133363779836178 0.495071975114524 no 1697 0.494679712665532 549 15992768
SGTC_951 1171-0579 82.7 µM -0.0161842044373669 0.493878846526555 no 1698 0.493543718423834 555 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2740 felodipine 17.08 µM -0.0162548668079027 0.493849242392058 no 1699 0.493515531924401 551 3333 L-type calcium channel blocker
SGTC_2624 nerol 100 µM -0.0165310411160161 0.493733538966984 no 1700 0.493405369119446 557 637566 A natural product oil.
SGTC_2712 st079126 47.7 µM -0.0169037873603397 0.493577377497491 no 1701 0.493256685661464 561 3152970
SGTC_1627 st003713 25.6 µM -0.0169047666008602 0.493576967247457 no 1702 0.49325629505683 559 16195070 YER133W GLC7
SGTC_2399 5884133 200 µM -0.0170002212736929 0.493536976816143 no 1703 0.493218219623576 559 722445
SGTC_924 2046-0044 21.3 µM -0.0170050015320299 0.493534974143834 no 1704 0.493216312852047 551 3623589
SGTC_1060 3448-7350 82 µM -0.0173513784251104 0.49338986120751 no 1705 0.49307814885206 558 570178
SGTC_743 1275-0778 158 µM -0.0173787551147275 0.493378391911886 no 1706 0.493067228779648 561 2849257 YMR203W TOM40
SGTC_474 dl-dihydrosphingosine 5 µM -0.0196502218920832 0.492426794856293 no 1707 0.492161200138784 563 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1506 4226-2149 212 µM -0.0196558123602454 0.49242445286416 no 1708 0.492158970295337 575 991114
SGTC_1024 4507-0395 26 µM -0.0198420249876234 0.492346443713798 no 1709 0.492084696690739 554 4201836
SGTC_389 tpck 16.7 µM -0.0206604920667756 0.492003570791608 no 1710 0.491758242525348 567 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1421 4029-0249 71.4 µM -0.0208865515541213 0.491908870790151 no 1711 0.491668077295167 556 2894095
SGTC_1924 st058459 75.1 µM -0.0215731314658773 0.491621254099753 no 1712 0.491394233263422 567 688683
SGTC_3064 1327-0027 10 µM -0.0215831354644323 0.491617063334705 no 1713 0.491390243174458 555 16000455 YPR107C YTH1
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.0216331685202356 0.491596104051138 no 1714 0.491370287532393 589 61125 An anti-inflammatory.
SGTC_891 0929-0073 133 µM -0.0234043659305203 0.490854149380954 no 1715 0.490663861226098 560 5603632
SGTC_1422 4031-0024 15.5 µM -0.023863428680181 0.490661853035917 no 1716 0.490480772827678 559 782427
SGTC_1979 st071809 45.3 µM -0.0246507411914715 0.490332061548018 no 1717 0.490166772980457 582 4976333
SGTC_645 0845-0943 5.41 µM -0.0252079804837749 0.49009864770242 no 1718 0.489944535737288 556 1885106
SGTC_1063 disulfiram 1.84 µM -0.0257916343834779 0.489854173063954 no 1719 0.489711767212905 553 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1946 st076057 65.1 µM -0.0264301403237004 0.489586726964625 no 1720 0.48945712702028 558 953009
SGTC_2007 4011539 71.82 µM -0.0275752070188721 0.489107113443215 no 1721 0.489000478038507 560 45595301
SGTC_234 nsc-17383 10.7 µM -0.0278025769546596 0.48901188093401 no 1722 0.488909805322927 561 408974
SGTC_2962 9082311 13.18 µM -0.0288156171631664 0.488587582918149 no 1723 0.488505822678562 562 16459453
SGTC_1011 4112-3381 17.4 µM -0.0290254998197618 0.488499678041468 no 1724 0.488422126622033 590 2877139
SGTC_1888 azatryptophan 97.5 µM -0.029826101096363 0.488164368429801 no 1725 0.48810287117959 568 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1254 0550-0035 264 µM -0.0315930200553235 0.487424373434869 no 1726 0.487398304900934 564 15121435
SGTC_1626 st003712 1.76 µM -0.0331694485661092 0.486764193313309 no 1727 0.48676973061141 570 24207035
SGTC_130 0136-0219 337.655 µM -0.0344448233993301 0.486230115555713 no 1728 0.486261220378449 563 234244
SGTC_2932 9016711 44.54 µM -0.0377446155265691 0.48484840692935 no 1729 0.484945651638422 580 7117328
SGTC_3207 9114163 49.47 µM -0.0385258164299024 0.48452132384312 no 1730 0.48463422411256 583 849233
SGTC_1913 st060213 96.1 µM -0.0395809824854696 0.484079550132607 no 1731 0.484213594667271 583 688959
SGTC_1481 3346-2004 36 µM -0.0397547160096866 0.484006813769075 no 1732 0.484144339528271 573 2770522
SGTC_932 2857-0803 154 µM -0.0411515118107636 0.483422042051843 no 1733 0.483587554434508 591 674898
SGTC_2138 5575593 77.673 µM -0.041337689874655 0.48334410085061 no 1734 0.483513343281029 563 762213
SGTC_2365 9042475 200 µM -0.0420456841079589 0.483047713440568 no 1735 0.483231139822151 561 6464479
SGTC_2391 6285546 200 µM -0.0421364490581006 0.483009717211181 no 1736 0.483194961907616 561 846083
SGTC_2974 9094440 9.66 µM -0.0421405148408512 0.483008015187589 no 1737 0.483193341334399 570 25236134
SGTC_1674 st016616 23.6 µM -0.0424061243612717 0.48289682603549 no 1738 0.483087473104251 569 625830
SGTC_2794 7785382 27.27 µM -0.0424756488958646 0.48286772197405 no 1739 0.483059761796327 567 2205081
SGTC_2570 licareol 100 µM -0.042496102080914 0.482859159967126 no 1740 0.483051609516998 590 443158
SGTC_2171 5739187 198.077 µM -0.0430474019880301 0.482628380632011 no 1741 0.482831873764397 558 2262761
SGTC_326 k292-0812 17.5 µM -0.0432302061645774 0.482551858362608 no 1742 0.482759013276087 588 3579357
SGTC_844 0330-0132 15.3 µM -0.0435114328229878 0.482434137460829 no 1743 0.482646925541713 565 2828079
SGTC_304 1310-0298 97 µM -0.0435747555174401 0.482407630921826 no 1744 0.482621687378727 568 1550234
SGTC_2407 paclitaxel 400 µM -0.0445653549436545 0.481992981532703 no 1745 0.482226878979478 627 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2695 st077686 51.995 µM -0.0449459400681665 0.481833679721327 no 1746 0.482075199471214 576 2876092
SGTC_1933 st074711 15.9 µM -0.0450454575042695 0.481792025108104 no 1747 0.482035537928297 569 17250958
SGTC_1122 capsaicin 818.572 nM -0.0453298026081175 0.481673009017826 no 1748 0.481922216400464 560 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2472 5377652 49.4 µM -0.0485473587440972 0.480326378243042 no 1749 0.48064001104592 595 1610903
SGTC_2346 9031566 143.75 µM -0.0503092504473025 0.479589074964214 no 1750 0.479937976157566 578 4771086
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0514368551595642 0.479117239856124 no 1751 0.479488708729567 573 1273210
SGTC_756 0508-1999 28.3 µM -0.0517267298105357 0.478995949359563 no 1752 0.479373219218317 578 6753853
SGTC_2884 9058502 51.95 µM -0.0519645163572511 0.478896455225043 no 1753 0.479278483520235 586 6471554
SGTC_296 1222-0039 74.9 µM -0.0540035344326699 0.478043348302349 no 1754 0.478466174141448 584 5984176
SGTC_3218 9131285 49.47 µM -0.0549506791408835 0.477647105408969 no 1755 0.478088878362101 585 17156417
SGTC_2220 6782180 200 µM -0.0554161184216361 0.47745239454859 no 1756 0.477903477462844 573 833803
SGTC_3336 9143619 71.43 µM -0.0556544118590391 0.477352709468542 no 1757 0.477808558621379 579 45595730
SGTC_2260 7964312 200 µM -0.0576327705774053 0.47652515974265 no 1758 0.477020572950252 592 231951
SGTC_894 0960-0238 55.9 µM -0.0616003286486194 0.474865834323214 no 1759 0.475440557608795 564 6741907 YDL195W SEC31
SGTC_2060 5238662 140 µM -0.0619665777531679 0.474712681933109 no 1760 0.475294723960175 585 790130
SGTC_3087 9117406 49.47 µM -0.0622754216672866 0.474583537261465 no 1761 0.475171750572634 573 42546093
SGTC_3285 9112818 20.8695 µM -0.0632922056587678 0.474158382746672 no 1762 0.474766911152094 570 17017947 YPR165W RHO1
SGTC_2066 5222451 176 µM -0.0633871494929264 0.474118684757583 no 1763 0.474729109946111 577 2281147
SGTC_896 0964-0007 44.5 µM -0.0636194528284846 0.474021554992385 no 1764 0.474636621000688 571 6756758
SGTC_1923 st058458 19.1 µM -0.063977463091185 0.473871868162651 no 1765 0.474494085942388 596 3534982
SGTC_979 1426-2828 121 µM -0.0643066042750932 0.473734254969753 no 1766 0.474363047445265 581 747872
SGTC_1630 st005209 31.3 µM -0.0659094330014262 0.473064160960684 no 1767 0.473724965233024 567 3367314
SGTC_1608 st001473 40.5 µM -0.0660400557282057 0.473009554899185 no 1768 0.473672967592004 600 7292267
SGTC_191 3914-0123 66.505 µM -0.0669576579076854 0.472625971067789 no 1769 0.473307705804003 594 3144412
SGTC_1771 st048882 4.1505 µM -0.0672544579825926 0.472501905603977 no 1770 0.473189566010343 576 4580403
SGTC_643 k048-0106 28.4 µM -0.0676086501961941 0.472353853132289 no 1771 0.473048584648462 589 6763920
SGTC_3080 9117754 49.47 µM -0.0680428753620077 0.47217235207194 no 1772 0.472875751873772 564 9550191
SGTC_161 4065-0411 162.148 µM -0.0691815600633762 0.471696422674288 no 1773 0.472422550437029 588 1906281 YLR208W SEC13
SGTC_2050 5263056 171 µM -0.0718413121066601 0.470584900261876 no 1774 0.471364097716802 595 763468 YGL055W OLE1
SGTC_1044 1222-0021 1.78 µM -0.0721264322198643 0.47046576072167 no 1775 0.471250645566383 588 4306703
SGTC_2589 lobaric acid 100 µM -0.0741194817541403 0.469633024707529 no 1776 0.470457656849783 578 73157 A novel microtubule depolymerizer.
SGTC_2112 5488546 200 µM -0.075242734502805 0.469163765492892 no 1777 0.470010791742536 590 600757
SGTC_604 1000-0114 314 µM -0.0756248755910818 0.469004128852112 no 1778 0.469858772636169 580 1572745
SGTC_1306 1185-0270 9.02 µM -0.07585051932177 0.468909870174439 no 1779 0.469769011624923 590 1548076
SGTC_2162 5663267 200 µM -0.0759698273896126 0.468860032043181 no 1780 0.469721551530415 622 6456493
SGTC_1170 0310-0127 64.8 µM -0.0766500375227702 0.468575899648762 no 1781 0.469450975910707 602 774975
SGTC_585 0kpi-0023 191 µM -0.077509595942415 0.468216874111421 no 1782 0.469109078891267 581 64601
SGTC_2614 arthonioic acid 13.39 µM -0.0777981862447207 0.468096339757613 no 1783 0.468994294622463 594 6710684
SGTC_2084 5306078 60.6385 µM -0.0780600872133048 0.467986955161974 no 1784 0.46889012803308 615 679340
SGTC_571 k831-0106 44.2 µM -0.078173245573995 0.467939694604359 no 1785 0.468845121906841 581 4783639
SGTC_2549 cedrol 20.94 µM -0.0783687095236581 0.467858060205366 no 1786 0.468767381570339 581 6708665 A sedative which affects the nervous system.
SGTC_1127 asiatic acid 681.4 nM -0.0788682285726776 0.467649445084728 no 1787 0.468568717212212 597 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2895 9054447 58.44 µM -0.0802736898392777 0.467062527390036 no 1788 0.468009791568465 578 2697450
SGTC_2277 7947813 106.88 µM -0.0805921224526625 0.466929560498785 no 1789 0.467883165599586 612 1246798
SGTC_929 2805-0021 398 µM -0.0807833832971877 0.466849698090726 no 1790 0.46780711154112 633 3098024
SGTC_1560 lithocholic acid 53.1 µM -0.0812395477217517 0.466659228588346 no 1791 0.467625724453359 586 9903 A bile acid which acts as a detergent.
SGTC_846 0335-0850 148 µM -0.0813841721749051 0.466598842859154 no 1792 0.467568218063994 590 6819598
SGTC_2313 7726885 200 µM -0.081814532123249 0.466419157195981 no 1793 0.46739709992664 582 726423
SGTC_1006 4099-6547 255 µM -0.0818306288899998 0.466412436540004 no 1794 0.467390699706233 586 3146833
SGTC_2489 cantharidin 73.42 µM -0.0818787369714817 0.466392350708398 no 1795 0.467371571547104 586 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1730 st033808 45.1 µM -0.0823490592780956 0.466195988744543 no 1796 0.467184571600757 578 1045166
SGTC_2851 9015922 71.43 µM -0.0825267031683937 0.466121823651926 no 1797 0.467113942348723 579 2996893
SGTC_3144 9087057 49.47 µM -0.0836958710872046 0.465633733622505 no 1798 0.46664912001178 610 17249618
SGTC_3065 9113888 49.47 µM -0.0837015659517936 0.465631356325482 no 1799 0.466646856033542 611 16648368
SGTC_1333 1482-0047 286 µM -0.084003968584651 0.465505121395252 no 1800 0.466526638224781 597 3811116
SGTC_3333 9141820 12.094 µM -0.0841107289354679 0.465460556191526 no 1801 0.466484197208577 602 1939433
SGTC_2664 lyso-paf C-16 73.48 µM -0.0847302013890459 0.465201977034239 no 1802 0.466237942530298 590 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1351 1496-0003 46.5 µM -0.0849879792995557 0.465094380132123 no 1803 0.466135473630732 589 3891978
SGTC_3244 9134489 49.47 µM -0.0865565899784671 0.464439694886833 no 1804 0.46551198625886 610 16584271
SGTC_922 1866-0035 480 µM -0.0869514521150151 0.464274907831806 no 1805 0.465355050740038 622 3156169
SGTC_1047 2043-3044 82 µM -0.0871805600967555 0.464179297446467 no 1806 0.465263995655469 608 669592
SGTC_418 lividomycin a 100 µM -0.0876178753364536 0.463996804625443 no 1807 0.465090197177643 584 72394 An antibiotic.
SGTC_1267 0828-0272 9.49 µM -0.0876215341782635 0.463995277812853 no 1808 0.465088743103294 594 745334
SGTC_1590 st077108 57.8 µM -0.0889465664843341 0.463442384877404 no 1809 0.464562187741052 582 5489485
SGTC_1901 st060216 58.6 µM -0.0891362129581585 0.463363257315749 no 1810 0.464486829072998 588 688792
SGTC_2646 retinol 96.75 µM -0.0894132404409745 0.463247673753395 no 1811 0.464376750634116 599 445354 A vitamin A analog and teratogen.
SGTC_3211 9128781 49.47 µM -0.0899758178787198 0.463012960374324 no 1812 0.464153215703458 615 17194361
SGTC_3243 9134147 49.47 µM -0.090656956799968 0.462728799104448 no 1813 0.463882586615567 589 24282180
SGTC_695 3505-6186 243 µM -0.0909872489486158 0.462591012853291 no 1814 0.463751361446324 597 1819379
SGTC_1516 st013856 110 µM -0.0910061315001728 0.462583135853328 no 1815 0.46374385952199 617 5281404 A mutagen and neurotoxin.
SGTC_1409 3909-8004 61.9 µM -0.0935243128166204 0.461532790041468 no 1816 0.462743517753233 576 2119279
SGTC_2539 epi(13)torulosol 80 µM -0.0944251610550066 0.46115710657644 no 1817 0.462385714732253 612 6708597
SGTC_2425 5628681 7.85 µM -0.0947997322753214 0.461000908191042 no 1818 0.462236949764525 583 5714958
SGTC_159 3970-0959 50 µM -0.0950865719892763 0.46088129842244 no 1819 0.462123031873569 597 6615653
SGTC_2484 5809818 12.04 µM -0.0957453729503694 0.460606597331644 no 1820 0.461861402001708 595 2870548
SGTC_2583 asiatic acid 100 µM -0.0966124334362222 0.460245086669567 no 1821 0.461517091116978 586 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_91 0417-1751 58.384 µM -0.0973013590912058 0.459957870640106 no 1822 0.461243538362523 584 6795624
SGTC_2079 5212404 121 µM -0.0997208322247511 0.458949348545132 no 1823 0.460282980627922 597 758462
SGTC_2606 farnesol 9.78 µM -0.0998552359480444 0.458893331997623 no 1824 0.460229627597919 582 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_341 1486-1430 230 µM -0.0999503173146901 0.45885370464567 no 1825 0.460191884440454 604 2054753 YPL210C SRP72
SGTC_1208 2323-2347 50.3 µM -0.101190008764517 0.458337072211005 no 1826 0.459699813929381 601 5412760
SGTC_776 4476-4378 112 µM -0.101511331266072 0.458203174834392 no 1827 0.459572281487303 598 2892008
SGTC_2047 4141938 200 µM -0.101916053452321 0.458034530965746 no 1828 0.459411653750449 593 3807862
SGTC_1410 3909-8106 77.9 µM -0.10211112324268 0.457953249943856 no 1829 0.459334236047638 592 1039210
SGTC_3067 9117431 49.47 µM -0.103728593756538 0.457279355841414 no 1830 0.458692367256865 602 17150885
SGTC_2160 5660466 132.927 µM -0.103772457524286 0.457261082381986 no 1831 0.458674962074061 635 2859134
SGTC_2363 9053361 176 µM -0.104385017104865 0.457005902120635 no 1832 0.458431906170751 612 6469797 YMR079W SEC14
SGTC_1476 4112-3294 3.34 µM -0.104441610230127 0.456982327431768 no 1833 0.458409451516418 583 704369
SGTC_1832 st054113 55 µM -0.105214061392447 0.456660566842933 no 1834 0.458102976637439 582 1251267
SGTC_2619 obliquin 87.91 µM -0.105555390432004 0.45651839701286 no 1835 0.457967560108325 601 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1709 st033179 39.1045 µM -0.106228235525523 0.456238160958996 no 1836 0.457700634489026 603 573381
SGTC_1204 4049-0315 18.3 µM -0.106744825023407 0.456023019212445 no 1837 0.457495710255883 595 588402
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.107321751264059 0.455782764531994 no 1838 0.457266864592677 629 689007
SGTC_2258 7960471 200 µM -0.107510741407087 0.455704065146531 no 1839 0.457191902151728 614 2974708
SGTC_1908 st060353 56.5 µM -0.107996428895104 0.455501822859865 no 1840 0.456999262485823 627 4227716
SGTC_2918 7977171 22.06 µM -0.108996400158915 0.45508546704083 no 1841 0.45660267279097 595 2236483
SGTC_2810 7959871 45.46 µM -0.110069475460482 0.454638727941495 no 1842 0.456177138044137 609 2974535
SGTC_541 4513-1321 94 µM -0.110557013810273 0.454435776535824 no 1843 0.455983818226313 585 747515
SGTC_1285 0929-0069 65.5 µM -0.111457303137172 0.454061037351146 no 1844 0.455626860869901 600 1206237
SGTC_2176 5809774 33.9695 µM -0.111531403032 0.454030195600949 no 1845 0.455597482458922 611 2870539
SGTC_2733 amorolfine 100 µM -0.111985869452889 0.453841044320206 no 1846 0.455417305316529 600 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_538 2922-0838 53.3 µM -0.112032890157918 0.453821474655887 no 1847 0.455398664074241 611 777039
SGTC_2594 a-mangostin 100 µM -0.112763428543832 0.453517444497991 no 1848 0.455109056576841 605 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2325 6158266 200 µM -0.113318378642451 0.453286507594494 no 1849 0.454889073520118 589 3623240
SGTC_2107 5363541 170.161 µM -0.114387395160693 0.452841691710315 no 1850 0.454465352806956 602 244052
SGTC_2051 5263410 176 µM -0.114572333449769 0.452764745203211 no 1851 0.454392054988794 590 227584
SGTC_1058 3448-5425 97.3 µM -0.114729825733952 0.452699219439872 no 1852 0.454329636252058 595 7279705
SGTC_2156 5649887 115 µM -0.115503993052019 0.452377140489124 no 1853 0.454022827831912 605 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1128 3448-9350 235 µM -0.117356683083677 0.45160648839595 no 1854 0.453288704349228 594 619386
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.118835291620572 0.450991571371325 no 1855 0.452702924056261 610 75037 A free radical scavenger.
SGTC_2819 7996655 46.38 µM -0.119637231421669 0.450658113369419 no 1856 0.452385262559122 607 6456960
SGTC_125 0133-0007 11.75 µM -0.120170704429971 0.45043630696134 no 1857 0.452173962025469 601 26541
SGTC_2076 5212012 200 µM -0.121119313757704 0.450041934230575 no 1858 0.451798265814494 600 604802
SGTC_1428 4049-0204 61.7 µM -0.121987724128501 0.449680946476333 no 1859 0.451454370192393 598 X1428
SGTC_2098 5376439 882.5 nM -0.125466441219597 0.448235306020652 no 1860 0.450077145545602 609 2844116
SGTC_307 1501-1223 22.3 µM -0.125666094544281 0.448152357331313 no 1861 0.449998120842011 621 2830329
SGTC_1012 4112-3522 18 µM -0.127297576000661 0.447474621438447 no 1862 0.44935243938581 617 3112398
SGTC_1728 st035614 33.7865 µM -0.127437713946782 0.447416413669853 no 1863 0.449296984075629 618 15945546
SGTC_317 4495-0002 170 µM -0.127857215358772 0.447242176124143 no 1864 0.44913098513381 614 15991618
SGTC_3317 9138495 8.753 µM -0.130677499819365 0.446071052842694 no 1865 0.448015216116878 602 17020139
SGTC_3293 9120939 62.045 µM -0.1310056659322 0.445934812197141 no 1866 0.4478854126356 621 934087
SGTC_2642 cholecalciferol 100 µM -0.131133700114958 0.445881659567258 no 1867 0.447834771251162 617 9821465 A vitamin D precursor, similar to steriods.
SGTC_2823 7987624 58.44 µM -0.13154186195234 0.445712220103659 no 1868 0.447673336602324 627 2239440
SGTC_319 1348-1596 45.5 µM -0.132021716907118 0.445513031491886 no 1869 0.447483557245392 640 5380505
SGTC_465 cgp-37157 41 µM -0.132618218860746 0.445265441691598 no 1870 0.447247661563372 616 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_697 0508-1955 564 µM -0.132731585114539 0.445218389222331 no 1871 0.44720283127849 606 6243113
SGTC_910 3454-3003 490 µM -0.132961170699086 0.445123102483766 no 1872 0.447112044536468 616 820824
SGTC_774 k060-0086 136 µM -0.133830071009898 0.444762504600886 no 1873 0.446768473929672 635 5911235
SGTC_2900 5328528 85.29 µM -0.134209776728264 0.444604939202818 no 1874 0.44661834757286 593 795359
SGTC_2985 9022375 71.43 µM -0.135615956372772 0.444021497274173 no 1875 0.446062445317405 648 4939335
SGTC_1755 st041960 45.185 µM -0.13648819535413 0.44365965503359 no 1876 0.445717677981944 613 2257073
SGTC_2108 5365811 200 µM -0.136873205294549 0.443499951276301 no 1877 0.445565509276889 594 780283
SGTC_3198 9112019 49.47 µM -0.139303418736964 0.442492101240386 no 1878 0.44460519423111 629 45595555
SGTC_311 1315-0136 58 µM -0.139814632357991 0.442280139575178 no 1879 0.444403225953563 613 6759207
SGTC_2998 9066762 71.4286 µM -0.13998520711916 0.442209418782452 no 1880 0.444335839153473 616 4945196
SGTC_2984 9022109 38.96 µM -0.140295164906834 0.442080914096711 no 1881 0.444213392194723 619 6459207
SGTC_1365 1672-3266 55.4 µM -0.141227928926478 0.441694238430938 no 1882 0.44384494154996 609 6415873
SGTC_1173 0443-0020 122 µM -0.141808071255576 0.441453769460392 no 1883 0.443615804281557 621 5331295
SGTC_2754 granisetron 64.02 µM -0.142295849427652 0.441251602124696 no 1884 0.443423162422123 631 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2735 sertaconazole 140 nM -0.1426894382432 0.441088484205544 no 1885 0.443267729210409 607 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2826 7992541 19.48 µM -0.144045581796354 0.440526524326826 no 1886 0.442732237934467 625 2985066
SGTC_939 1165-0479 45.3 µM -0.145517933152634 0.439916545789135 no 1887 0.442150978921103 626 1377347
SGTC_736 0958-0254 92.6 µM -0.146838161479561 0.439369711311879 no 1888 0.441629881318879 629 6812352
SGTC_670 4204-0025 119 µM -0.147154715844864 0.439238612629584 no 1889 0.441504951455937 618 719039
SGTC_2485 5633444 17.78 µM -0.147633693075777 0.439040260376878 no 1890 0.441315931614 608 5724239
SGTC_722 3534-0461 190 µM -0.147695447293153 0.439014688065121 no 1891 0.441291562382688 603 658262
SGTC_100 0086-0128 49.5915 µM -0.147697749727294 0.439013734636153 no 1892 0.441290653808551 666 93297
SGTC_811 0416-0114 265 µM -0.148373317791426 0.438733999850621 no 1893 0.441024078149549 602 6612453
SGTC_489 paxilline 115 µM -0.148408176762637 0.438719566505881 no 1894 0.44101032370396 659 105008 A toxic potassium channel blocker.
SGTC_956 1185-0240 191 µM -0.148485508412987 0.438687547654261 no 1895 0.440979810895222 626 1416193
SGTC_1768 st044301 37.178 µM -0.151416888455042 0.437474119571741 no 1896 0.439823433998771 619 3931349
SGTC_2912 7964298 10.93 µM -0.151750950132589 0.437335873741175 no 1897 0.43969168504331 607 2975850
SGTC_1716 st033144 30.6155 µM -0.152236331060151 0.437135020610835 no 1898 0.43950026993262 625 674617
SGTC_2273 7815444 169.05 µM -0.152474462832221 0.437036486376781 no 1899 0.439406365314561 660 2824616
SGTC_735 3076-0345 636 µM -0.152828465566113 0.43689001424285 no 1900 0.439266774573563 603 2888990
SGTC_1320 1313-0481 95.3 µM -0.155132227969117 0.435937021975952 no 1901 0.438358537743996 594 6813365 YLR208W SEC13
SGTC_648 0375-0473 33.3 µM -0.155867740001865 0.435632842393434 no 1902 0.438068637110208 630 1713139
SGTC_619 1652-1634 108 µM -0.156882504770933 0.435213237125084 no 1903 0.437668724141385 621 5400454
SGTC_82 0054-0107 293.755 µM -0.157185211073796 0.435088082161544 no 1904 0.437549441634773 606 3104697
SGTC_36 0335-0881 14.2 µM -0.157260393972342 0.435056998540843 no 1905 0.437519816422822 616 23828853
SGTC_1343 1487-0095 224 µM -0.159597025825482 0.434091142378931 no 1906 0.436599260999019 651 4560101 YGL055W OLE1
SGTC_306 1672-3436 11.6 µM -0.159629098445314 0.434077887756155 no 1907 0.436586627827644 619 6797378
SGTC_2376 9072922 81.32 µM -0.159949925604686 0.433945303885607 no 1908 0.436460259907606 657 17087968
SGTC_1182 1222-0449 220 µM -0.160717011309994 0.43362833097531 no 1909 0.436158145261433 609 658318
SGTC_3111 9122088 49.47 µM -0.16232818724657 0.432962704777696 no 1910 0.435523709415009 624 16876704
SGTC_2375 9072683 200 µM -0.163296690332114 0.432562677831112 no 1911 0.43514241982988 624 16798029
SGTC_1820 st053765 18.6 µM -0.163528053865079 0.432467126501223 no 1912 0.435051343324459 624 3690829
SGTC_795 0685-0265 78 µM -0.163682011340967 0.432403545455668 no 1913 0.434990739706344 617 302754
SGTC_3332 9141069 11.198 µM -0.16371546544239 0.432389729880284 no 1914 0.434977571079836 627 17332883
SGTC_2106 5357045 167.29 µM -0.165889139447078 0.431492243380886 no 1915 0.434122097268782 627 668842
SGTC_31 0508-1974 57.237 µM -0.166537955877125 0.431224422395691 no 1916 0.433866807868616 605 6810525
SGTC_2089 5281248 129.67 µM -0.166636218027237 0.431183864114715 no 1917 0.433828147123544 615 2737878
SGTC_2708 st078559 56 µM -0.167935120847287 0.430647802681909 no 1918 0.433317160019398 609 17250902
SGTC_3247 9135149 49.47 µM -0.168302994075953 0.430496003374167 no 1919 0.433172459265445 611 8934436 YOR116C RPO31
SGTC_1569 carminic acid 40.6 µM -0.168577830409448 0.43038260153708 no 1920 0.43306435986838 605 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2121 5257820 149.641 µM -0.169109660193644 0.430163176432373 no 1921 0.432855193316447 608 791256
SGTC_2921 7974240 10.71 µM -0.170248819401834 0.42969324883954 no 1922 0.432407229875225 639 2979074 YDR527W RBA50
SGTC_1824 st053723 68.6 µM -0.171400607718826 0.429218212726312 no 1923 0.431954388479886 648 675225
SGTC_1916 st067606 49.2 µM -0.171641353168197 0.429118934159665 no 1924 0.431859747375428 625 19590279
SGTC_2629 bisabolol 100 µM -0.172638082244893 0.428707950973436 no 1925 0.431467958003084 629 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.172930664859632 0.428587324484849 no 1926 0.431352963846609 645 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_352 k048-0007 5.11 µM -0.174421373585411 0.427972836214191 no 1927 0.430767159040972 667 6811911
SGTC_45 0kpi-0036 14.9 µM -0.174712145218117 0.42785299691778 no 1928 0.430652912028729 618 2795021
SGTC_2595 hexamethylquercetagetin 100 µM -0.175233617764726 0.427638092687359 no 1929 0.430448034919726 662 386331
SGTC_694 1315-0438 43.2 µM -0.175698678343988 0.427446454519149 no 1930 0.430265336840768 649 6793154
SGTC_1065 prochlorperazine maleate 2.48 µM -0.176117558161334 0.427273860773596 no 1931 0.430100793554608 627 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2025 5147754 141 µM -0.176346167736844 0.42717967116884 no 1932 0.430010996850861 633 315777 YLR208W SEC13
SGTC_2421 5690543 90.72 µM -0.176667799095576 0.427047162618251 no 1933 0.429884667783776 650 3397993
SGTC_1451 4152-0210 104 µM -0.177434215250183 0.426731440871565 no 1934 0.429583666894693 672 659563
SGTC_2491 paeonol 100 µM -0.178818544921262 0.426161291473067 no 1935 0.429040091620852 639 11092 Increases levels of cortical cytochrome oxidase.
SGTC_923 1900-2434 73.3 µM -0.179099653298474 0.426045533112052 no 1936 0.428929727116562 634 5910570
SGTC_255 tunicamycin 200.472 nM -0.179143990428323 0.426027275989786 no 1937 0.428912320652679 650 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3129 9127257 49.47 µM -0.179534413278668 0.425866514703606 no 1938 0.428759049197005 680 837894
SGTC_1491 4138-0063 26.5 µM -0.181082863530098 0.425229043347914 no 1939 0.428151267577165 640 23883227
SGTC_971 1315-0384 26.7 µM -0.181505875799369 0.425054930111434 no 1940 0.427985260765881 653 6769120
SGTC_2321 7390090 138.78 µM -0.181663102630269 0.424990218757078 no 1941 0.427923561961802 647 649046
SGTC_1904 st060225 78 µM -0.18358320238691 0.424200108460372 no 1942 0.427170220848721 614 66595
SGTC_2517 totarol 10 µM -0.183754128059666 0.42412978821883 no 1943 0.427103171883539 627 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_590 k048-0076 22.4 µM -0.18391920041148 0.42406187837487 no 1944 0.427038420997805 642 6832814
SGTC_2996 9066192 71.4286 µM -0.184301231830317 0.423904721432854 no 1945 0.426888573809743 640 6472854
SGTC_2077 5212015 200 µM -0.185248083202351 0.423515265720906 no 1946 0.426517228371999 619 780900
SGTC_77 0828-0286 12.516 µM -0.185557743974371 0.423387913289992 no 1947 0.426395796697201 633 745345
SGTC_2385 9074692 200 µM -0.185822179175048 0.423279166858359 no 1948 0.426292105490472 612 17046906
SGTC_2326 6164455 177.58 µM -0.185949678316572 0.423226736151099 no 1949 0.426242111924913 638 2888790
SGTC_1470 k295-0292 231 µM -0.18617920471122 0.423132352815869 no 1950 0.426152115539385 615 5045612
SGTC_2414 st077232 92.9 µM -0.186450390464556 0.423020844459922 no 1951 0.426045789641622 610 729801
SGTC_1201 1889-3372 45.9 µM -0.190654657076133 0.42129289430987 no 1952 0.424398082683624 627 5392199
SGTC_1337 1486-1011 40.3 µM -0.191399690548776 0.420986843212371 no 1953 0.424106231244979 624 X1337
SGTC_476 mead acid 10 µM -0.192290854365165 0.4206208261887 no 1954 0.423757190941602 630 5312531 An omega 9 fatty acid.
SGTC_1747 st037496 66.6 µM -0.19414697084351 0.419858706372793 no 1955 0.423030401925578 618 723305
SGTC_2195 6536160 144.242 µM -0.194233373478569 0.419823236822403 no 1956 0.422996576095006 624 3834386
SGTC_2516 gossypol 71.55 µM -0.195736710056417 0.419206199577963 no 1957 0.422408124839448 660 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_487 nimodipine 119 µM -0.19574807588527 0.419201535283082 no 1958 0.422403676569212 638 4497 L-type voltage-gated calcium channels inhibitor
SGTC_179 1273-0063 6.77 µM -0.196130640012604 0.419044545713929 no 1959 0.4222539573546 671 3108139
SGTC_2288 7946289 167.31 µM -0.197892746530153 0.418321611914253 no 1960 0.421564489692169 666 1246052
SGTC_2193 5925765 200 µM -0.199444573930068 0.417685176985151 no 1961 0.420957497920459 639 877370
SGTC_540 1187-0821 17.3 µM -0.200464875346852 0.417266848652847 no 1962 0.420558512909975 651 847520
SGTC_2986 9022445 71.43 µM -0.201120952997813 0.416997903192686 no 1963 0.420301999304831 664 6459286
SGTC_1658 st012944 20 µM -0.201540809437513 0.416825812102746 no 1964 0.420137861353566 672 24207260
SGTC_2587 piperic acid 92.2 µM -0.202139984420947 0.416580249394444 no 1965 0.41990364498013 628 5370536
SGTC_406 estrone 100 µM -0.202215719569961 0.416549212816521 no 1966 0.419874042270544 650 5870 A steroid.
SGTC_265 mycophenolic acid 32.932 µM -0.202419672152068 0.416465634790571 no 1967 0.419794325278248 654 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_182 3448-4371 550.524 µM -0.203505891606968 0.416020575040703 no 1968 0.419369820598149 607 3491403
SGTC_635 k038-0028 24.7 µM -0.204604070743086 0.415570724474589 no 1969 0.418940737347578 656 4035102
SGTC_1471 k673-0312 37 µM -0.204830570652778 0.415477956348245 no 1970 0.418852250721727 635 24099884
SGTC_1811 st050069 61.5 µM -0.204977197580338 0.415417904507735 no 1971 0.418794970229375 638 3877702
SGTC_1075 aripiprazole 15.2 µM -0.206056676715225 0.414975858968581 no 1972 0.418373319744555 637 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1368 1852-0141 284 µM -0.206118797763164 0.414950423736231 no 1973 0.418349057770848 654 2838987
SGTC_2709 st078560 56 µM -0.207580494909777 0.414352040377398 no 1974 0.417778267715994 660 17250903
SGTC_1040 k898-0338 155 µM -0.20825683671566 0.414075229615039 no 1975 0.417514216009732 656 20969351
SGTC_1194 1488-0194 225 µM -0.209357639614634 0.41362478825371 no 1976 0.417084529331489 637 1391452
SGTC_781 4335-2806 94.4 µM -0.209891930766093 0.413406200728793 no 1977 0.416876010136777 676 845254
SGTC_294 k038-0071 157 µM -0.210232386691538 0.413266928459336 no 1978 0.416743151712328 644 24152826
SGTC_3042 9091578 49.47 µM -0.211213050826138 0.412865823574712 no 1979 0.416360513691514 610 25236497
SGTC_493 zm226600 134 µM -0.211629814366876 0.412695389170232 no 1980 0.416197923810763 676 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2736 butenafine 14.65 µM -0.211675650983437 0.412676645404881 no 1981 0.416180042675038 645 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2063 5246145 200 µM -0.211938503618092 0.412569162083017 no 1982 0.416077505655901 665 711240
SGTC_3324 9138759 60.749 µM -0.212594003142462 0.412301149722794 no 1983 0.41582182466295 663 45595710
SGTC_360 0957-0399 1.01 µM -0.212928510395253 0.412164396375557 no 1984 0.415691362095263 672 6752301 YPR165W RHO1
SGTC_1631 benzylvanillin 81.9 µM -0.213096744588275 0.412095622855976 no 1985 0.415625751887454 649 75506
SGTC_1540 guanosine 70.6 µM -0.213836286741571 0.411793332786808 no 1986 0.415337363323459 634 6802 Guanosine is a purine nucleoside
SGTC_2374 9071832 200 µM -0.214501988127762 0.411521270109036 no 1987 0.415077808371691 649 17381698
SGTC_3313 9133968 57.047 µM -0.216995063183147 0.410502764798097 no 1988 0.414106096146278 655 1494643
SGTC_780 0109-0199 192 µM -0.217559831737162 0.410272121345098 no 1989 0.413886042201935 639 610414
SGTC_651 3253-0966 34.4 µM -0.217696020948308 0.410216508247261 no 1990 0.413832982077909 642 781462
SGTC_544 k015-0020 52.4 µM -0.217790509726352 0.410177924653645 no 1991 0.413796169614103 613 3008304
SGTC_2846 9008642 19.48 µM -0.218477079373979 0.40989759660501 no 1992 0.413528707495075 706 2992898
SGTC_3215 9129942 49.47 µM -0.219255908826935 0.409579654405009 no 1993 0.413225352942246 668 17682944
SGTC_3005 9076496 71.4286 µM -0.221455562479415 0.408682009695982 no 1994 0.412368866793143 648 21368410
SGTC_2728 chlorpromazine 9.18 µM -0.221858808703265 0.408517502932751 no 1995 0.412211898652477 634 2726 A thorazine and dopamine antagonist.
SGTC_2486 5283202 22.39 µM -0.222191012906773 0.408381990304152 no 1996 0.41208259496779 649 1377751
SGTC_2027 5150920 200 µM -0.222540810965379 0.40823931263705 no 1997 0.411946453550961 654 786715
SGTC_413 propylparaben 100 µM -0.224100303917024 0.407603365842001 no 1998 0.411339628001859 655 7175 A pharmaceutical preservative.
SGTC_2917 7979103 53.79 µM -0.225279354320142 0.407122721483167 no 1999 0.410880979877483 680 2980565
SGTC_2436 5633522 8.09 µM -0.225913552312947 0.406864246058734 no 2000 0.410634328535578 672 5724242
SGTC_1436 4092-1007 8.32 µM -0.227513007983876 0.406212548035802 no 2001 0.410012427760349 626 2881121
SGTC_2991 9074669 71.4286 µM -0.229520085024751 0.405395132404438 no 2002 0.409232355828427 673 17333109
SGTC_75 0159-0059 199.013 µM -0.230096754208976 0.405160350372429 no 2003 0.409008293500387 624 5377270
SGTC_3288 9119690 36.221 µM -0.230190854425823 0.40512204214603 no 2004 0.40897173408587 667 17595618 YKL019W RAM2
SGTC_2848 9016370 25.97 µM -0.23028348320521 0.405084333830113 no 2005 0.40893574712138 627 7894410
SGTC_2767 sibutramine 71.45 µM -0.230485367501261 0.405002151661603 no 2006 0.408857316242355 686 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2800 7887935 81.82 µM -0.230834490886868 0.404860041942755 no 2007 0.40872169244448 681 2961002
SGTC_132 0417-1715 25.805 µM -0.231549362388058 0.404569094621135 no 2008 0.408444020766551 667 6769098
SGTC_2877 9040724 71.43 µM -0.232033272654076 0.40437217671903 no 2009 0.408256085544695 655 6463895
SGTC_3343 9148379 18.9835 µM -0.232304978985302 0.40426162171016 no 2010 0.408150572770203 652 1955036
SGTC_1290 0986-0249 10.2 µM -0.233333385223384 0.403843241208465 no 2011 0.40775126815169 660 53329
SGTC_1531 st059297 52.4 µM -0.2340902818629 0.403535387605846 no 2012 0.407457445153764 641 7566702
SGTC_1727 st034309 9.9045 µM -0.234846045181952 0.403228054584727 no 2013 0.407164114043075 689 870305
SGTC_2243 6634756 200 µM -0.235830358243355 0.402827870877167 no 2014 0.406782154997488 633 885676
SGTC_2774 tamoxifen 10.92 µM -0.235837260713043 0.402825064958226 no 2015 0.40677947683225 647 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_181 1447-1644 8.07 µM -0.237372571912355 0.402201071113039 no 2016 0.406183883082898 673 534600
SGTC_1243 0416-0003 5.65 µM -0.237738620897116 0.402052335188215 no 2017 0.406041913576136 668 2141977
SGTC_491 tetrandrine 80.3 µM -0.238011667116133 0.401941398118502 no 2018 0.405936022577204 665 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1948 st076329 66.6 µM -0.238192942583753 0.40186775132713 no 2019 0.405865725311274 670 24208413
SGTC_2718 lomofungin 53.02 µM -0.238195284821424 0.401866799768936 no 2020 0.405864817028941 665 5351222 A RNA synthesis inhibitor.
SGTC_2839 9003951 25.97 µM -0.238502630588612 0.401741942431904 no 2021 0.405745637650315 664 2990634
SGTC_1440 4100-1550 40 µM -0.238769323065527 0.401633608371594 no 2022 0.405642229464851 671 742806
SGTC_2439 5492030 7.2 µM -0.240073560227949 0.401103918773534 no 2023 0.405136615387355 664 5722370
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.241090482937453 0.40069104217502 no 2024 0.404742494388326 655 4620898
SGTC_328 k915-0120 63.5 µM -0.241440045520378 0.400549143305447 no 2025 0.404607039371245 648 6624543
SGTC_430 0958-0115 16.4 µM -0.242120501052054 0.400272961834829 no 2026 0.404343396593629 658 6833180
SGTC_1717 st033143 58.0435 µM -0.242990664537751 0.399919854876045 no 2027 0.404006314689319 679 674616
SGTC_1098 clofazimine 15.1 µM -0.243391719784723 0.39975713666543 no 2028 0.403850978819702 643 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.244382248536069 0.399355328855521 no 2029 0.403467394336915 639 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2584 androsterone 48.74 µM -0.245192804587142 0.399026606217294 no 2030 0.403153573741817 666 2754130 A steroid.
SGTC_107 0358-0022 2.6945 µM -0.245432518139044 0.398929403611502 no 2031 0.40306077649324 695 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_800 3448-7362 155 µM -0.245866965498254 0.398753253430858 no 2032 0.402892608347498 658 15991913
SGTC_210 3551-0445 56.827 µM -0.246645037802037 0.398437829308687 no 2033 0.402591472980097 685 2865180 YOR207C RET1
SGTC_466 geldanamycin 89.2 µM -0.247076186038863 0.398263073906544 no 2034 0.402424631632482 661 5288382 HSP90 inhibitor.
SGTC_2200 6600604 21.907 µM -0.24709586266862 0.398255098952066 no 2035 0.402417017794796 688 2904777
SGTC_2242 6630449 61.2675 µM -0.247373704807344 0.398142493839513 no 2036 0.402309511215256 671 691249 YDR170C SEC7
SGTC_2464 5717415 7.67 µM -0.248059218807604 0.397864701942091 no 2037 0.402044294138584 660 5285744
SGTC_1970 st070122 35.8 µM -0.248204369426209 0.397805888969813 no 2038 0.40198814290083 700 102928
SGTC_1875 nocodazole 6 µM -0.249868080666988 0.397131942950784 no 2039 0.401344684158137 647 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3241 9133421 49.47 µM -0.251850246215807 0.396329396538836 no 2040 0.400578408945228 663 17018221
SGTC_2869 9037858 32.47 µM -0.254428161563756 0.39528629808991 no 2041 0.399582398419033 643 27187042
SGTC_3152 9099253 49.47 µM -0.254662693630712 0.395191436793667 no 2042 0.399491816275542 659 25236131
SGTC_2596 sinensetin 100 µM -0.254792904538381 0.395138773007191 no 2043 0.399441527905281 658 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_405 ebelactone b 50 µM -0.257547148281457 0.394025269629012 no 2044 0.39837821168763 648 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1156 4092-0367 4.88 µM -0.257639685528422 0.393987873057398 no 2045 0.39834249937519 648 1357585
SGTC_101 0490-5701 117.494 µM -0.257739185233322 0.393947663876292 no 2046 0.39830410103547 657 4661669
SGTC_3352 9151559 45.5865 µM -0.259757029083292 0.393132470292132 no 2047 0.397525599599091 646 17159339
SGTC_111 0083-0039 52.457 µM -0.259758736518058 0.393131780699295 no 2048 0.397524941028461 641 759313
SGTC_3096 9117468 49.47 µM -0.261822398225196 0.392298561893927 no 2049 0.396729184991219 702 41316311
SGTC_1349 flufenamic acid 69 µM -0.261866666276131 0.392280693731639 no 2050 0.396712119755314 671 3371 A non-steroidal anti-inflammatory.
SGTC_573 3702-0553 84.7 µM -0.26203185822064 0.392214018383622 no 2051 0.396648440372112 671 1222756
SGTC_1435 4092-0789 56.7 µM -0.263222502370447 0.391733540157678 no 2052 0.396189543898975 665 2248285
SGTC_973 1325-0077 65.9 µM -0.263664729700008 0.391555123637096 no 2053 0.396019137824868 684 2835149
SGTC_1117 retinoic acid 1.10837 µM -0.264176838316158 0.391348542029641 no 2054 0.395821828808655 687 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2829 7992743 58.44 µM -0.264214047770976 0.391333533147619 no 2055 0.395807493512747 677 16462845
SGTC_864 0469-0573 172 µM -0.26464653034589 0.391159097963594 no 2056 0.395640885836097 679 689425
SGTC_245 methotrexate 289.6 µM -0.26615647567678 0.390550256624575 no 2057 0.395059350856613 665 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2993 9054257 71.4286 µM -0.266961411856291 0.390225799155028 no 2058 0.394749436000941 685 6470217 YGL055W OLE1
SGTC_3029 9088683 49.47 µM -0.267372230716954 0.390060233803379 no 2059 0.394591289030378 666 25236615
SGTC_815 1582-0027 36.9 µM -0.267891905517449 0.389850826661097 no 2060 0.394391262256559 657 3128206
SGTC_1759 st043059 70 µM -0.268526512756017 0.389595149927328 no 2061 0.394147034883819 698 669426
SGTC_2280 7785178 200 µM -0.27044052809509 0.388824302586878 no 2062 0.393410682175298 651 2954328
SGTC_279 1273-0055 2.93 µM -0.270533619197297 0.388786822364346 no 2063 0.393374878217323 674 2847562
SGTC_1174 0739-0097 51.1 µM -0.270866631368412 0.388652753899812 no 2064 0.393246805113718 673 728447
SGTC_2723 salbutamol 83.58 µM -0.271578108180179 0.388366362564633 no 2065 0.392973217069519 689 9884233 β2-adrenoceptor agonist
SGTC_1677 st019204 53.9 µM -0.271629753716185 0.388345576005852 no 2066 0.392953359587121 676 3945625
SGTC_52 0329-0193 875 nM -0.272805076308096 0.387872612734859 no 2067 0.392501528599737 694 3739292
SGTC_2844 9010103 25.97 µM -0.274696382115504 0.387111878989419 no 2068 0.391774755465833 725 2480525
SGTC_709 3807-1509 243 µM -0.27550695426318 0.386785977707059 no 2069 0.391463391875195 691 1886677 YPL242C IQG1
SGTC_2219 9098279 200 µM -0.275836484761356 0.38665350840698 no 2070 0.391336829797222 672 902349
SGTC_2115 tiliquinol 12.7705 µM -0.276245390042345 0.386489149278283 no 2071 0.391179798410123 694 71208 A bioactive hydroxyquinoline.
SGTC_1185 1319-0113 81.3 µM -0.27668875538727 0.386310961965066 no 2072 0.391009553410361 695 4672763
SGTC_1224 0823-0416 294 µM -0.277485880228447 0.385990660004031 no 2073 0.39070352312865 679 3598164
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.277501377070174 0.385984433807928 no 2074 0.39069757428799 723 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1431 4049-0260 9.09 µM -0.277545773611235 0.385966596686263 no 2075 0.390680531734521 671 3854841
SGTC_2531 methyl deoxycholate 70.07 µM -0.277749714947693 0.385884662625276 no 2076 0.390602247227512 695 16667744 Haematoxylin.
SGTC_3115 9123671 49.47 µM -0.277794880689779 0.38586651783746 no 2077 0.390584910597185 661 3286988
SGTC_657 3534-0529 86.7 µM -0.278511120499509 0.38557881060303 no 2078 0.390310014845262 688 1049549
SGTC_219 mitoxanthrone 164.414 µM -0.27965699231288 0.385118654934362 no 2079 0.38987033866747 678 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_537 1334-0398 209 µM -0.279866905481734 0.385034376159222 no 2080 0.389789809290058 686 5846986
SGTC_3103 9120822 49.47 µM -0.280088003078993 0.384945612781168 no 2081 0.389704994325332 691 17141819
SGTC_771 0250-0039 27.3 µM -0.280705710685775 0.384697655558646 no 2082 0.389468064151917 677 3005115
SGTC_1474 0330-0125 5.35 µM -0.281308997863852 0.384455532432286 no 2083 0.389236704781326 671 X1474
SGTC_1804 st050076 49.1 µM -0.282052068222744 0.384157370710744 no 2084 0.388951792821349 662 3895976
SGTC_2318 6029776 164 µM -0.282133678051071 0.384124628420678 no 2085 0.388920505186339 706 818325
SGTC_1559 coumarin 343 70.1 µM -0.282142087688632 0.384121254477088 no 2086 0.388917281134346 689 108770 A hepatotoxic, DNA x-linker.
SGTC_890 0929-0006 47.2 µM -0.282228492817873 0.384086589278717 no 2087 0.388884155937138 676 1378169
SGTC_2232 chlorophetanol 41.5365 µM -0.282779085617401 0.383865716676747 no 2088 0.388673093758652 676 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_721 1187-1332 279 µM -0.28303382373594 0.383763540174872 no 2089 0.38857545451838 685 25730
SGTC_2073 5212005 126 µM -0.28312047668014 0.383728785165911 no 2090 0.388542242688848 697 691789
SGTC_785 1270-0111 65.3 µM -0.283225528433969 0.383686651964434 no 2091 0.388501980164716 653 6741994
SGTC_591 4299-0174 154 µM -0.283406505915783 0.383614070388232 no 2092 0.388432620874685 684 5509088
SGTC_2849 9019321 12.99 µM -0.283742097416318 0.383479491192531 no 2093 0.388304015459677 645 16489627
SGTC_2727 riluzole 51.77 µM -0.286012733979015 0.382569288621901 no 2094 0.387434184238939 679 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2336 9001819 198.65 µM -0.286209218697755 0.382490556579184 no 2095 0.387358941727645 689 2989602
SGTC_1673 st016611 27.3 µM -0.287389932694576 0.382017543173515 no 2096 0.386906884386964 723 5226799
SGTC_1690 st023502 41.2 µM -0.287679044871952 0.381901746896397 no 2097 0.386796216003618 657 24207482
SGTC_2902 5787006 60.46 µM -0.288013607327338 0.381767759893789 no 2098 0.386668161333428 680 591003
SGTC_3267 9137951 49.47 µM -0.288351802163134 0.381632332574638 no 2099 0.386538728900252 665 16643986
SGTC_1861 st057647 17.4 µM -0.288611713843973 0.381528262940972 no 2100 0.386439265226847 694 688668
SGTC_1321 1326-2144 215 µM -0.290050442952795 0.380952345391676 no 2101 0.385888823777828 699 3513030
SGTC_3208 9114115 49.47 µM -0.290347342953678 0.380833530273436 no 2102 0.385775261754417 711 650895
SGTC_2349 9023730 187.07 µM -0.290630541580072 0.380720208719011 no 2103 0.385666949525742 691 4126287
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.292517145909351 0.379965548074402 no 2104 0.384945626170119 668 16725076
SGTC_470 aa-861 153 µM -0.293044609102664 0.379754639102807 no 2105 0.384744027241401 665 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2271 7849410 118.62 µM -0.293385169748748 0.379618483108649 no 2106 0.384613879901133 715 972430
SGTC_750 4073-0104 132 µM -0.293564727422559 0.379546702038935 no 2107 0.384545266068812 688 22330957
SGTC_1978 st071761 42 µM -0.296359126033675 0.378430132684048 no 2108 0.383477918334694 659 5147680
SGTC_806 3966-4455 5.86 µM -0.298503835844535 0.37757384956411 no 2109 0.382659324456976 717 714982
SGTC_1710 st031758 61.5 µM -0.298725373791642 0.377485433937703 no 2110 0.382574797540873 685 5394341
SGTC_548 1436-0017 110 µM -0.298903400289609 0.377414388349975 no 2111 0.382506876297326 690 9677137
SGTC_2499 avocadenofuran 51.48 µM -0.299647249004666 0.377117583233587 no 2112 0.38222311985862 710 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1258 0671-0043 57.1 µM -0.299673298864693 0.377107190321976 no 2113 0.382213183747369 713 4298767
SGTC_402 epigallocatechin gallate 10 µM -0.301225602068795 0.376488040853285 no 2114 0.381621234154284 687 65064 An antioxidant.
SGTC_1511 0906-3109 28.5 µM -0.302096257377629 0.376140911434706 no 2115 0.3812893427113 670 2882180
SGTC_3105 9121040 49.47 µM -0.30377885944216 0.375470343737316 no 2116 0.380648186902001 661 41448907
SGTC_876 0720-0963 56.8 µM -0.304412500141112 0.375217916161273 no 2117 0.380406822837845 728 765861
SGTC_997 3996-0078 137 µM -0.304582205448958 0.375150318617905 no 2118 0.380342187221443 679 735687
SGTC_3246 9135460 32.98 µM -0.307317029698466 0.374061505065003 no 2119 0.379301037322806 680 41446951
SGTC_1092 toremifene 6.32 µM -0.309635022577836 0.373139429926116 no 2120 0.378419260060647 724 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1147 3809-1045 12.3 µM -0.309990621425615 0.372998040255624 no 2121 0.378284044164315 663 325925
SGTC_2001 4023502 57.655 µM -0.311040751739289 0.372580597808857 no 2122 0.377884820838879 666 108941 YCR052W RSC6
SGTC_2287 7945887 168.79 µM -0.311118132295291 0.372549843797961 no 2123 0.377855408573076 678 1245853
SGTC_698 k064-0052 127 µM -0.312757557792604 0.371898464276613 no 2124 0.377232431380526 691 5088751
SGTC_759 3486-0358 89.3 µM -0.312860500215711 0.37185757521567 no 2125 0.37719332418202 710 875103
SGTC_1100 amiodarone 5.07 µM -0.31302289947389 0.371793072647687 no 2126 0.377131632255492 663 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_168 3970-0862 530.542 µM -0.313212346443071 0.371717831679287 no 2127 0.37705966945815 675 3135186
SGTC_381 3461-2219 42.7 µM -0.313612222475189 0.371559032560613 no 2128 0.376907787684976 730 2883159
SGTC_3066 9117245 49.47 µM -0.315249547630324 0.370909044790819 no 2129 0.376286094212517 696 17176980
SGTC_122 0236-0016 402.397 µM -0.31631034608817 0.37048812385561 no 2130 0.375883479481265 687 6808838
SGTC_1311 1190-0148 100 µM -0.317883751714305 0.369864087848405 no 2131 0.3752865590387 683 1961333
SGTC_2432 5630864 12.22 µM -0.317916018653496 0.369851293880486 no 2132 0.375274320688874 708 5714970
SGTC_1657 st012939 43.4 µM -0.318580263291306 0.369587950302349 no 2133 0.37502241090505 691 24207257
SGTC_1266 0828-0227 32.9 µM -0.319143203175358 0.369364817448625 no 2134 0.374808961911715 691 3913820
SGTC_2397 5161689 200 µM -0.320038098472181 0.369010197801117 no 2135 0.374469724880752 710 2259942
SGTC_2304 7443016 91.4 µM -0.322032261222761 0.368220373418005 no 2136 0.373714127180386 703 939854
SGTC_2074 5212007 75.395 µM -0.323514837153645 0.367633532827275 no 2137 0.373152686372707 670 758611
SGTC_3231 9132313 49.47 µM -0.325503144174203 0.366846996379914 no 2138 0.372400151687318 701 4905967
SGTC_1932 st074806 40.9 µM -0.326529513635365 0.366441202550052 no 2139 0.372011881613618 683 17251235
SGTC_3190 9110366 49.47 µM -0.326919897084043 0.366286896516563 no 2140 0.371864235778142 720 17123768
SGTC_705 1124-0212 310 µM -0.328310056742353 0.36573758678201 no 2141 0.371338620523528 701 9554485
SGTC_2791 5663188 71.43 µM -0.329586383358314 0.365233499461088 no 2142 0.370856256366983 727 54690634
SGTC_2447 5741742 33.78 µM -0.330273435647978 0.36496224332754 no 2143 0.370596681548462 684 1776504
SGTC_1307 1187-1599 12.2 µM -0.330275948375687 0.364961251397714 no 2144 0.370595732324319 681 1538471
SGTC_1788 fluconazole 20 µM -0.331660688747815 0.364414745943404 no 2145 0.3700727439025 729 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2792 7535235 81.82 µM -0.331876149721859 0.364329736262113 no 2146 0.369991390218267 677 1281891
SGTC_883 0850-0245 24.6 µM -0.332889374685707 0.363930059992367 no 2147 0.369608895121268 687 6823229 YPR165W RHO1
SGTC_1518 st038567 90.8 µM -0.333214139315369 0.363801984777475 no 2148 0.369486322898484 710 77966
SGTC_1308 1187-1617 41.4 µM -0.33328083190902 0.363775685556286 no 2149 0.369461153512091 694 2882570
SGTC_3107 9121808 49.47 µM -0.333420584265238 0.363720578398158 no 2150 0.369408413622319 671 662681
SGTC_495 decylubiquinone 155 µM -0.335115050845675 0.363052640839516 no 2151 0.368769149860454 724 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2553 4-methylesculetin 85.09 µM -0.336930922841143 0.362337308926647 no 2152 0.36808448689861 697 5319502
SGTC_557 1315-0110 16.2 µM -0.337880531318091 0.361963417945087 no 2153 0.367726609705593 674 6833801
SGTC_2177 5811945 192 µM -0.338577901204768 0.361688925146709 no 2154 0.367463866302737 692 5343475
SGTC_867 0518-0118 155 µM -0.340934615586182 0.360761822568354 no 2155 0.366576402423334 710 6848158
SGTC_504 lovastatin 124 µM -0.341698915094482 0.360461331823115 no 2156 0.366288744324795 737 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2955 9076254 12.21 µM -0.341942474842086 0.360365592364955 no 2157 0.36619709193462 687 16459619
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.341965924549335 0.360356375120397 no 2158 0.366188268129997 723 229346 A bile salt which induces apoptosis.
SGTC_3191 9110352 49.47 µM -0.342062189355436 0.360318537704888 no 2159 0.366152045739493 701 17122424
SGTC_3110 9122132 49.47 µM -0.342117347115678 0.360296858258025 no 2160 0.366131291589854 674 918317
SGTC_2898 9056270 58.44 µM -0.342662283879241 0.360082698084776 no 2161 0.365926269891173 662 19154699
SGTC_3056 9094900 49.47 µM -0.345715372884699 0.358883647777699 no 2162 0.364778314985452 706 25236784
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.34587688867853 0.358820253703452 no 2163 0.364717619038969 702 5379071
SGTC_423 5-fluorouracil 457 µM -0.346200793888687 0.358693134383112 no 2164 0.364595909067088 680 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1526 st051518 75 µM -0.347180427752408 0.358308764151556 no 2165 0.364227886913912 696 673993
SGTC_609 0986-0026 86.3 µM -0.347633445502743 0.358131066113504 no 2166 0.364057742600706 695 2848610
SGTC_3290 9121031 71.43 µM -0.348013760586316 0.357981909713908 no 2167 0.363914924626964 667 17014854
SGTC_773 4358-1457 44.6 µM -0.348076577339009 0.35795727559341 no 2168 0.363891337159121 742 1186886
SGTC_861 0443-0273 110 µM -0.349009492204079 0.357591494813479 no 2169 0.363541091686327 702 6149169
SGTC_2925 9010536 32.5 µM -0.349218542296625 0.357509547586941 no 2170 0.363462623359209 695 2994177
SGTC_1780 st038448 24.544 µM -0.349727010798637 0.357310256358317 no 2171 0.363271790279602 732 728868 YDL195W SEC31
SGTC_1850 st056238 17 µM -0.350616782056486 0.356961609419434 no 2172 0.362937932305477 705 5393177
SGTC_264 promethazine 12.5 mM -0.351333710038976 0.356680776053336 no 2173 0.362669003944229 706 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.351917242894386 0.356452253246402 no 2174 0.362450163702426 686 676296 Flavone; oxidizing agent.
SGTC_2319 6033012 152.6 µM -0.35350750875879 0.355829736008242 no 2175 0.361854000263383 681 847246
SGTC_2623 humulene 100 µM -0.35433877000606 0.355504487593862 no 2176 0.361542507916372 706 6187145 An anti-inflammatory.
SGTC_1014 4130-3005 69.3 µM -0.354738355491153 0.355348178806536 no 2177 0.361392806854121 712 743608
SGTC_1197 1601-0112 267 µM -0.354969346395161 0.355257831495132 no 2178 0.361306277892853 700 7350313
SGTC_1895 st058434 18.3 µM -0.355721657439181 0.354963637017466 no 2179 0.361024512130978 738 5393175
SGTC_812 4251-0442 148 µM -0.356015399753941 0.354848791276985 no 2180 0.360914516223382 714 5723007
SGTC_593 1203-0218 61.7 µM -0.35660779329593 0.354617220666149 no 2181 0.360692721195394 724 3666956
SGTC_2024 5144227 134 µM -0.357683486997872 0.354196862167793 no 2182 0.36029009605467 699 3475211
SGTC_1660 st012960 28.1 µM -0.359152215039974 0.353623200967528 no 2183 0.359740610910545 739 24207266
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.359568988485435 0.353460476526902 no 2184 0.359584739057108 694 442882
SGTC_3338 9144300 39.5675 µM -0.359770106794067 0.353381961753758 no 2185 0.359509529846223 707 4901274
SGTC_2255 7941087 197.44 µM -0.360567467025133 0.35307074094398 no 2186 0.359211406526148 712 935561
SGTC_1512 0259-0544 12.2 µM -0.360671264083122 0.353030234729454 no 2187 0.359172604365563 680 18476
SGTC_1725 st036284 20.55 µM -0.3616844332656 0.352634938719019 no 2188 0.358793930541484 693 707914
SGTC_144 4161-2749 112.381 µM -0.363170268036119 0.352055516257649 no 2189 0.358238848112745 692 797501 YMR168C CEP3
SGTC_1527 coumarin 137 µM -0.363449594541132 0.351946627201573 no 2190 0.358134529919639 764 323 A hepatotoxic, DNA x-linker.
SGTC_930 2810-3379 265 µM -0.365912109803822 0.350987198093105 no 2191 0.357215329891787 751 1015764
SGTC_964 1287-0107 19.4 µM -0.366864370881645 0.350616438514628 no 2192 0.356860094551096 706 51516812 YPR165W RHO1
SGTC_3012 9080433 71.4286 µM -0.368139991541987 0.350120002937019 no 2193 0.356384426322186 722 17688859
SGTC_3226 9131256 49.47 µM -0.370850924337467 0.349065835424128 no 2194 0.355374284704748 685 17178073
SGTC_2865 9030313 51.95 µM -0.370854653510627 0.349064386105517 no 2195 0.355372895846358 693 42562754
SGTC_1952 st077036 64.1 µM -0.370916335493703 0.349040414128044 no 2196 0.355349923863853 720 2937007
SGTC_3342 9147791 14.508 µM -0.371063672836845 0.348983155640251 no 2197 0.355295053713933 723 1838168
SGTC_1490 4089-0339 670 nM -0.3713781315176 0.34886096167703 no 2198 0.355177955657742 714 742542
SGTC_1743 st037606 46.3785 µM -0.372171975975822 0.348552555288519 no 2199 0.354882404884224 680 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1153 4055-0057 267 µM -0.372176843103831 0.348550664731136 no 2200 0.354880593106369 703 882706
SGTC_334 1502-1024 68.5 µM -0.372540888048144 0.348409268009549 no 2201 0.354745087470437 731 3296216
SGTC_1652 st011932 78 µM -0.372653266112927 0.348365624108762 no 2202 0.354703261563084 709 1551076
SGTC_2437 5741531 144.16 µM -0.373080478450533 0.348199727380049 no 2203 0.354544273714481 702 2262990
SGTC_1032 k061-1018 98.7 µM -0.373645174526378 0.347980487009468 no 2204 0.354334159928325 736 4005393
SGTC_2238 6671620 73.2395 µM -0.375018415877973 0.347447545196537 no 2205 0.35382338531289 688 729941
SGTC_1180 1193-0155 285 µM -0.375466459256299 0.347273729018064 no 2206 0.353656793252733 724 2921347
SGTC_62 0180-0423 3.232 µM -0.375600967083574 0.347221553648649 no 2207 0.353606785848756 735 30102 YGL099W LSG1
SGTC_3145 9085516 49.47 µM -0.375671947278368 0.347194021712543 no 2208 0.353580397805933 693 25236195
SGTC_1701 st028638 40.4 µM -0.376007376707212 0.347063925604982 no 2209 0.353455705976959 719 3490878
SGTC_3022 9087993 49.47 µM -0.376343405334092 0.346933615169851 no 2210 0.353330807171171 695 17173644
SGTC_2135 5326629 150.42 µM -0.376387325721791 0.346916584372414 no 2211 0.353314483526548 695 5020077
SGTC_3140 9094243 49.47 µM -0.376507382986537 0.346870031922645 no 2212 0.353269863892112 731 19291112
SGTC_2143 5623677 140.463 µM -0.377442402997211 0.346507555152125 no 2213 0.352922430026738 673 5375313
SGTC_2605 digitonin 300 nM -0.378004665437567 0.346289651963174 no 2214 0.352713564081053 716 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2975 9084847 53.72 µM -0.381777747882586 0.344828723893067 no 2215 0.351313112718004 692 27211724
SGTC_754 3474-0146 171 µM -0.384630248680675 0.343725775018255 no 2216 0.350255689938063 694 24762078
SGTC_2645 abamectin 100 µM -0.385624765117377 0.343341546903762 no 2217 0.349887294670207 716 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3275 9138069 49.47 µM -0.387467977311671 0.342629856229951 no 2218 0.349204893723057 722 17617007
SGTC_363 0455-0021 3.06 µM -0.387636406733972 0.342564851012936 no 2219 0.349142561412597 719 4597466
SGTC_155 k072-0202 43.6 µM -0.388067593789477 0.342398455923021 no 2220 0.348983006383521 715 5857737
SGTC_2850 9015429 58.44 µM -0.38826722284234 0.342321429425576 no 2221 0.348909145349752 714 6457570
SGTC_2270 7924575 90.91 µM -0.388367638893006 0.342282686559004 no 2222 0.348871994437954 729 1262135
SGTC_1697 st025554 27.742 µM -0.391053480593375 0.341247042949908 no 2223 0.347878852599718 698 1269519
SGTC_254 nsc-64875 3.808 µM -0.391943008704729 0.340904309471121 no 2224 0.347550161924613 730 56993
SGTC_184 1494-0393 24.714 µM -0.392229362908689 0.340794005660229 no 2225 0.347444375183077 717 3090647
SGTC_2463 5473429 200 µM -0.393417470839665 0.340336491252871 no 2226 0.347005583995401 719 5399405
SGTC_472 calcifediol 10 µM -0.393600605948641 0.3402659908023 no 2227 0.346937966891671 705 5283731 A vitamin D metabolite.
SGTC_2726 cimetidine 79.27 µM -0.395020996799851 0.339719380994503 no 2228 0.346413696140379 725 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1619 st003326 88.7 µM -0.396530230678282 0.339138950820265 no 2229 0.345856955411204 681 2849032
SGTC_589 1227-0070 34.1 µM -0.396862012850366 0.339011403165154 no 2230 0.34573460903125 696 2841384
SGTC_3330 9141424 71.43 µM -0.397727735505154 0.338678678664829 no 2231 0.345415445238094 699 27261020
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.39843708841461 0.338406145781764 no 2232 0.345154011775723 725 5355888
SGTC_1865 st057639 52.2 µM -0.399570660113035 0.337970804050961 no 2233 0.344736385022854 701 688818
SGTC_1666 st014829 29 µM -0.39994182679994 0.337828306653813 no 2234 0.344599682091468 716 3858230
SGTC_1848 st056003 16.4 µM -0.400781848978104 0.337505893259192 no 2235 0.344290371805259 695 146492
SGTC_2140 5586273 200 µM -0.40117907749282 0.337353472376593 no 2236 0.344144141836023 711 854421
SGTC_2118 5526350 200 µM -0.401215197433988 0.337339614087317 no 2237 0.344130846317904 731 743594
SGTC_1754 st042065 16.137 µM -0.401668890040224 0.337165562741402 no 2238 0.343963861400681 731 1126236 YIL048W NEO1
SGTC_827 3253-0474 693 µM -0.402357975483831 0.336901273660484 no 2239 0.34371029662278 742 5402065
SGTC_1401 3807-4679 7.6 µM -0.402486042430566 0.336852164242399 no 2240 0.343663179198346 721 3291456
SGTC_2762 leflunomide 42.06 µM -0.403324959639808 0.336530536188751 no 2241 0.343354591201228 719 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_882 0843-0131 351 µM -0.404427916926133 0.336107861148376 no 2242 0.342949037365249 705 5425421
SGTC_2936 9038235 15.59 µM -0.408030004652128 0.33472891509261 no 2243 0.341625823356372 702 4749415
SGTC_1462 k081-0014 26.5 µM -0.408405864503749 0.334585156895651 no 2244 0.341487864312208 730 3270634
SGTC_574 1315-0397 40 µM -0.409322828330277 0.33423453999666 no 2245 0.341151382386651 717 6794277
SGTC_960 1222-0186 7.7 µM -0.410287158453092 0.333865967755988 no 2246 0.340797655518904 741 3126296
SGTC_3355 9151058 44.0485 µM -0.410441329571702 0.333807057558185 no 2247 0.34074111682764 712 17015728
SGTC_1251 0490-5699 265 µM -0.411661496158962 0.333340965314787 no 2248 0.340293775250006 747 3883818
SGTC_18 0111-0177 500 nM -0.412043558725293 0.333195073827299 no 2249 0.340153748343851 751 721752
SGTC_2206 7254556 146.969 µM -0.41215276979344 0.333153375961589 no 2250 0.340113726258612 706 4398905
SGTC_1448 4255-0083 152 µM -0.414074038575517 0.332420154233734 no 2251 0.339409942556484 760 5399660
SGTC_312 4092-0653 6.84 µM -0.418290875632254 0.330813115075282 no 2252 0.337867229996099 723 1148278
SGTC_467 ro 31-8220 72.8 µM -0.418348083093903 0.330791334615343 no 2253 0.337846319521476 720 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1867 st057372 64 µM -0.418359613204811 0.330786944853176 no 2254 0.337842105095278 717 688837
SGTC_1556 plumbagin 1.48 µM -0.419181948254419 0.330473924189123 no 2255 0.337541581919486 736 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1442 4112-3290 3 µM -0.421436121560205 0.32961648480093 no 2256 0.336718323597575 751 704353
SGTC_2099 5377090 177.372 µM -0.421676988415328 0.329524917033919 no 2257 0.336630401531198 740 2243829
SGTC_1391 3442-0225 151 µM -0.422122404278456 0.329355614993946 no 2258 0.336467837794165 695 5227075
SGTC_1025 k007-0731 70 µM -0.422571732629861 0.329184861263293 no 2259 0.336303877079872 706 6256118
SGTC_2197 6588183 93.1375 µM -0.423336843486258 0.328894185884774 no 2260 0.336024758414441 709 884136
SGTC_285 1486-1325 46 µM -0.42458576689995 0.328419926267884 no 2261 0.335569335254098 719 22310230
SGTC_3280 9140961 49.47 µM -0.427463833035952 0.327328077645322 no 2262 0.334520761189745 740 4901226
SGTC_832 4083-0019 164 µM -0.427800818361908 0.327200332239869 no 2263 0.334398070539808 739 1990758
SGTC_2673 kobusone 100 µM -0.428918318260272 0.326776851942452 no 2264 0.333991334387837 737 6710676 An epoxy ketone and protein crosslinker.
SGTC_397 arbidol 50 µM -0.42915367260232 0.326687692049048 no 2265 0.333905697361591 714 131410 A RNA synthesis inhibitor.
SGTC_3162 9099653 49.47 µM -0.4294557238802 0.326573279684924 no 2266 0.333795804379846 714 25237511
SGTC_2876 9059903 25.97 µM -0.430038882743926 0.326352434254394 no 2267 0.3335836785309 739 6916095
SGTC_1299 1079-1439 3.74 µM -0.431391523383198 0.325840416310082 no 2268 0.333091856167344 753 323161
SGTC_545 4218-0007 221 µM -0.431737810161261 0.325709388381333 no 2269 0.332965991822088 756 2840508
SGTC_2395 5646831 180.19 µM -0.431759851949151 0.32570104894222 no 2270 0.332957980962726 774 6808628
SGTC_204 PMA1.184 62.41 µM -0.433260926596575 0.325133327633275 no 2271 0.332412610487789 737 2252213 YGL008C PMA1
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.434301165420765 0.324740136900527 no 2272 0.332034878832577 710 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_615 k087-0205 167 µM -0.43437683533951 0.32471154270403 no 2273 0.332007408214776 733 9642773
SGTC_3018 9082602 49.47 µM -0.435622316923229 0.324241047870713 no 2274 0.331555388115119 741 17332089
SGTC_3229 9132204 49.47 µM -0.436207783678517 0.324019978019968 no 2275 0.331342990536102 727 17682924
SGTC_1366 1683-0113 21.9 µM -0.440181869319401 0.322521022859926 no 2276 0.329902695071481 736 708623
SGTC_3098 9119039 49.47 µM -0.441091953758398 0.322178159477447 no 2277 0.329573214173212 730 17161528
SGTC_2102 5377816 72.7585 µM -0.44161474221386 0.321981273586153 no 2278 0.329384007113745 755 1379702
SGTC_1196 1588-0294 184 µM -0.443435736892855 0.321295864259266 no 2279 0.328725295899996 759 6144269
SGTC_2704 st078022 71.1 µM -0.444663561081609 0.320834063155116 no 2280 0.328281453164358 758 54697681
SGTC_2178 5812956 200 µM -0.444778174411396 0.32079096967717 no 2281 0.328240034266175 730 5403383
SGTC_2677 mitomycin C 100 µM -0.445793901105647 0.320409172066223 no 2282 0.327873063864707 736 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3340 9146634 11.102 µM -0.445967241974188 0.32034403459995 no 2283 0.327810454383848 745 4907387
SGTC_126 0417-1624 672.48 µM -0.448999577221975 0.319205450323441 no 2284 0.32671598081243 760 41912 YDL195W SEC31
SGTC_988 1497-1057 103 µM -0.451219582105911 0.318372959776027 no 2285 0.325915648796863 773 3533044
SGTC_280 3448-3607 3.04 µM -0.45184573213814 0.318138322187778 no 2286 0.325690060736557 742 626179
SGTC_3304 9125678 46.087 µM -0.452680690005029 0.31782555143936 no 2287 0.325389343111288 745 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2693 st077581 40.7 µM -0.45463473249141 0.317094085731193 no 2288 0.324686021510297 740 25238761
SGTC_1803 st050068 52.4 µM -0.455419600574218 0.316800483302255 no 2289 0.324403698387194 742 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_572 0960-0087 17.7 µM -0.456371910100773 0.316444399488615 no 2290 0.324061280774504 738 6796365
SGTC_1813 st051246 8.6015 µM -0.459534585019327 0.315263046479843 no 2291 0.322925161043571 735 5291959
SGTC_652 0437-0092 114 µM -0.459755532280569 0.315180586478492 no 2292 0.322845852273877 718 3091274
SGTC_2352 9027995 87.8 µM -0.460308398328659 0.31497429100896 no 2293 0.322647436936598 731 2997347
SGTC_693 4161-2696 114 µM -0.46099005402223 0.314720018637688 no 2294 0.322402870430873 745 805759
SGTC_2364 9055074 200 µM -0.461371659456653 0.314577709864477 no 2295 0.322265990414208 776 6470630
SGTC_2460 5552655 174.22 µM -0.462462830940832 0.31417094086539 no 2296 0.321874725519263 748 5401989
SGTC_1382 3002-2117 298 µM -0.462972313564844 0.313981092187548 no 2297 0.321692106260817 777 1497314
SGTC_1524 corynanthine 62.1 µM -0.463042985272884 0.313954761652254 no 2298 0.321666778051976 773 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_273 hydroxyurea 18.1 mM -0.463168160113215 0.313908126918936 no 2299 0.321621918364465 754 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2300 7976697 71.57 µM -0.463580619006009 0.313754483604597 no 2300 0.321474121307541 728 2236109
SGTC_3255 9139072 49.47 µM -0.465381410198875 0.313084057074499 no 2301 0.320829172172512 734 17646060
SGTC_3121 9125696 49.47 µM -0.465385688604982 0.313082464977421 no 2302 0.320827640514099 758 1235365
SGTC_1610 st001799 48.1 µM -0.466506633556732 0.312665454736298 no 2303 0.320426450233976 723 621897
SGTC_744 1594-0068 283 µM -0.467020530809988 0.312474356473293 no 2304 0.320242594630382 738 668392
SGTC_2480 5767542 37.17 µM -0.467519186897989 0.312288973996285 no 2305 0.32006423399289 723 2867358
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.46755625953975 0.3122751936124 no 2306 0.320050975411642 759 4213774
SGTC_1724 st037281 8.293 µM -0.468447781794577 0.311943882301451 no 2307 0.319732202524848 720 574124 YDL195W SEC31
SGTC_1036 k216-0215 33.5 µM -0.468900026989073 0.311775875136364 no 2308 0.319570548509397 736 622330
SGTC_1650 st011916 45.8 µM -0.469465209013247 0.311565967477849 no 2309 0.319368573668862 772 242528
SGTC_666 0272-0154 136 µM -0.472211774206367 0.31054677044837 no 2310 0.318387818192556 739 6870312
SGTC_2807 7945238 51.95 µM -0.474450815076198 0.309716980049578 no 2311 0.317589231989947 773 17148797
SGTC_1380 2291-0730 164 µM -0.476052772986719 0.309123887318051 no 2312 0.317018390765996 748 2999191
SGTC_2173 5763948 167 µM -0.476346540453187 0.309015179712765 no 2313 0.316913756934993 741 2867177
SGTC_108 0509-0257 621.132 µM -0.47791518801959 0.308434990522576 no 2314 0.316355285449751 736 536624
SGTC_2979 9012552 45.46 µM -0.480090392440355 0.307631247918478 no 2315 0.315581559760575 756 17100905
SGTC_81 0411-0046 9.971 µM -0.480386840556485 0.30752178106037 no 2316 0.315476174886619 764 12925265
SGTC_2088 5278280 127.392 µM -0.480587866774722 0.30744755958061 no 2317 0.315404720252853 757 791502
SGTC_868 0527-0199 213 µM -0.480959037270154 0.307310539350738 no 2318 0.315272806091304 761 2849450
SGTC_3074 9116018 49.47 µM -0.481261431125943 0.307198928384722 no 2319 0.315165352584294 783 17027303
SGTC_2761 levamisole 97.89 µM -0.481784734055129 0.30700582397863 no 2320 0.314979437556524 770 26879 An alkaline phosphatase inhibitor.
SGTC_500 h-89 112 µM -0.482125162458878 0.306880230969464 no 2321 0.314858517938317 784 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_395 anisomycin 6.25 µM -0.482350836628273 0.306796986311637 no 2322 0.314778369775923 762 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2008 4012253 172 µM -0.482461853506934 0.306756039059627 no 2323 0.314738945341966 727 603940
SGTC_1302 1159-0335 255 µM -0.483419146187765 0.306403053155563 no 2324 0.314399078176792 749 649284
SGTC_354 2783-3500 4.88 µM -0.483967239654179 0.306201033536682 no 2325 0.314204559586904 762 6740761
SGTC_582 0987-0078 156 µM -0.485946093533941 0.305472146220185 no 2326 0.313502693262192 770 1625765
SGTC_1091 telmisartan 47.6 µM -0.487498061694683 0.304901036002603 no 2327 0.31295270805308 777 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_3021 9087658 49.47 µM -0.488144549362534 0.304663274450148 no 2328 0.312723728946159 753 25237042
SGTC_180 1486-1293 102.781 µM -0.489875107443048 0.304027225812533 no 2329 0.312111139301047 759 4140536
SGTC_1242 0402-0103 60.1 µM -0.493228232742761 0.302796507375458 no 2330 0.310925665620011 759 432868
SGTC_250 brefeldin a 552.239 µM -0.493775316279358 0.302595919781419 no 2331 0.310732433731004 750 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1845 st056753 3.01 µM -0.494175707623695 0.302449154474021 no 2332 0.310591047130176 733 5375839
SGTC_952 1185-0122 232 µM -0.495598739946042 0.301927793882652 no 2333 0.310088770997772 751 678600
SGTC_1976 st070609 63.5 µM -0.496381701821785 0.301641110110313 no 2334 0.309812566285269 750 682556
SGTC_3311 9131146 2.8755 µM -0.496423984835892 0.30162563154628 no 2335 0.309797653200158 753 4900406 YPR165W RHO1
SGTC_554 4483-2211 187 µM -0.496795558718046 0.301489624676824 no 2336 0.309666613733584 747 747107
SGTC_3335 9143315 29.6265 µM -0.496830748521872 0.301476745613773 no 2337 0.309654204929983 734 4899691
SGTC_123 0083-0120 66.675 µM -0.497105205478167 0.301376306024663 no 2338 0.309557431998636 753 16001701
SGTC_1989 st071868 50.2 µM -0.497796979468956 0.30112321298809 no 2339 0.309313572567726 758 16414057
SGTC_1270 0831-1170 17.3 µM -0.497971386053587 0.301059419562701 no 2340 0.309252105201544 758 6764716
SGTC_1568 digitonin 820 nM -0.498114061414038 0.301007237129984 no 2341 0.309201825068407 793 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2680 butyl paraben 22.24 µM -0.50049709577751 0.300136263862135 no 2342 0.308362550293256 781 7184 An antifungal and steroid mimetic.
SGTC_1233 0325-0408 14.2 µM -0.500658495469532 0.300077315253096 no 2343 0.30830574348121 776 12874
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.501681912289819 0.299703650878854 no 2344 0.307945644918453 756 5106787 A p450 inhibitor.
SGTC_1080 nisoldipine 24.4 µM -0.502405190255216 0.299439698745663 no 2345 0.307691264413715 778 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2934 9036370 36.88 µM -0.505016149392895 0.298487736870015 no 2346 0.306773746637941 740 6462800
SGTC_1043 0916-0009 19.3 µM -0.505232085506507 0.298409067736429 no 2347 0.306697918542824 788 3101130
SGTC_2294 7971431 200 µM -0.505583832643117 0.29828094058682 no 2348 0.306574416781715 796 5741572
SGTC_2456 5770359 74.46 µM -0.507488922085041 0.297587429763612 no 2349 0.305905903649148 789 3118787
SGTC_1160 4092-0570 10.5 µM -0.507551881567097 0.29756452315505 no 2350 0.305883821614522 775 4994975
SGTC_1328 1441-0025 69.2 µM -0.507745021939777 0.297494257730986 no 2351 0.305816085110691 763 4562601
SGTC_2168 5727979 200 µM -0.508015221291233 0.297395970584005 no 2352 0.305721334301816 747 695210
SGTC_783 0848-0141 92.7 µM -0.50882036399643 0.297103181556302 no 2353 0.305439072036929 752 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1372 2752-0194 270 µM -0.508896231722114 0.297075599159413 no 2354 0.305412480727336 763 823334
SGTC_133 0724-0033 378.92 µM -0.510200188922538 0.296601716875776 no 2355 0.304955609923848 752 280309
SGTC_674 0498-0004 451 µM -0.511005879491866 0.296309087129864 no 2356 0.304673469902502 756 4231473
SGTC_2544 sphondin 68.51 µM -0.511210110246772 0.29623493081471 no 2357 0.304601969986109 751 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2478 5763493 32.33 µM -0.51135209317255 0.29618338174195 no 2358 0.304552267045772 751 1365576 YLR208W SEC13
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.512793688336356 0.295660221740346 no 2359 0.30404782265248 750 688761
SGTC_1980 st071811 45.7 µM -0.513425287519725 0.295431146036559 no 2360 0.303826930238002 793 4974850
SGTC_1129 3453-1384 223 µM -0.514265378187451 0.295126578808537 no 2361 0.303533232024373 810 1084452
SGTC_3159 9100096 49.47 µM -0.515118866945822 0.294817302372803 no 2362 0.303234979708773 747 25236875
SGTC_1693 xanthone 101.9 µM -0.515782156445875 0.294577051159157 no 2363 0.303003283195035 788 7020 An insecticide.
SGTC_3041 9091929 49.47 µM -0.51652542164451 0.294307939190496 no 2364 0.302743744191619 769 25236887
SGTC_3149 9097855 49.47 µM -0.517692135849319 0.293885739365649 no 2365 0.302336543002415 757 25236625 YMR079W SEC14
SGTC_1480 1070-0044 41.2 µM -0.518346506515788 0.293649064401588 no 2366 0.302108265180488 763 3124987
SGTC_1609 st001574 46.4 µM -0.518986848998689 0.293417548647381 no 2367 0.301884956048022 786 3960012
SGTC_887 0885-0007 9.62 µM -0.521031910684106 0.292678723710447 no 2368 0.301172270929309 771 5719458
SGTC_1002 4049-0206 172 µM -0.522088829800577 0.292297226697066 no 2369 0.300804241728824 768 4662749
SGTC_1620 st003704 16.5 µM -0.522824268303177 0.29203190527088 no 2370 0.300548274876988 766 2834414
SGTC_787 4152-0075 138 µM -0.523749616185143 0.29169823031453 no 2371 0.300226350525607 745 9566539
SGTC_618 k072-0232 33.2 µM -0.524500074036971 0.291427750227174 no 2372 0.299965384164983 782 5872756 YGL099W LSG1
SGTC_2149 5554786 194.827 µM -0.525138155992718 0.291197864747004 no 2373 0.299743576499393 762 745063 YPR165W RHO1
SGTC_3063 1327-0034 4 µM -0.52529249362226 0.291142273354311 no 2374 0.2996899373876 770 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3043 9092303 49.47 µM -0.525627526181549 0.291021613902851 no 2375 0.299573513810008 758 25236084
SGTC_1151 3909-8316 15.3 µM -0.526155716840376 0.290831437478723 no 2376 0.299390009569844 774 800431
SGTC_1113 artemisinin 1.17947 µM -0.527335761214867 0.29040676944609 no 2377 0.298980222283885 777 2240 An anti-malaria and mitochondrial poison.
SGTC_3350 9150499 3.57 µM -0.528466483822064 0.290000123634118 no 2378 0.298587801844875 784 4910996 YPR165W RHO1
SGTC_1162 k048-0130 20.1 µM -0.529869381311315 0.28949596599428 no 2379 0.298101248245318 787 6797406
SGTC_805 3852-0218 479 µM -0.530272070022011 0.289351328291242 no 2380 0.297961654301323 762 6615355
SGTC_1273 0849-0096 14.1 µM -0.530906238047868 0.289123616731697 no 2381 0.297741877394071 780 5286025
SGTC_892 0929-0076 29 µM -0.533568617060318 0.288168553451256 no 2382 0.296820012863198 745 5751038
SGTC_2299 7976368 114.88 µM -0.533861710498483 0.288063504369152 no 2383 0.296718607398116 769 2979718
SGTC_1921 5740136 50 µM -0.535746218077273 0.287388500666432 no 2384 0.296066978284856 796 1774243
SGTC_1263 0774-1208 64.8 µM -0.536151489196104 0.287243436151425 no 2385 0.295926928614575 813 906585
SGTC_1159 4092-0538 61.2 µM -0.537128424896771 0.286893890046056 no 2386 0.295589453742788 771 717301
SGTC_691 1548-0686 185 µM -0.537202063448302 0.286867550455258 no 2387 0.295564023047929 790 46495133
SGTC_825 1988-2224 89.6 µM -0.53770249349573 0.286688583234731 no 2388 0.295391228758737 761 1180859
SGTC_550 4123-0385 25.7 µM -0.540788466687107 0.285586127868462 no 2389 0.294326696607312 788 5731123
SGTC_324 1315-0088 19.6 µM -0.543515577832401 0.284613557476687 no 2390 0.29338743411963 786 6787421
SGTC_947 3447-0010 211 µM -0.543669154717448 0.284558834381328 no 2391 0.293334581014872 782 748350
SGTC_2082 5219693 150 µM -0.545657829329798 0.283850676535578 no 2392 0.292650582420229 779 2834649
SGTC_3284 9108171 64.8615 µM -0.545763461859856 0.28381308488714 no 2393 0.29261427116387 780 8687505
SGTC_2682 pyrogallin 40.03 µM -0.547719222145566 0.283117515712803 no 2394 0.291942355658003 773 822798 An ATP competetive kinase inhibitor.
SGTC_104 0074-0074 590.992 µM -0.548522273213388 0.28283214644921 no 2395 0.291666669922031 762 3943124
SGTC_508 roscovitine 141 µM -0.549073255687968 0.28263643129865 no 2396 0.291477589021823 785 160355 A CDKinase inhibitor.
SGTC_850 0388-0143 75.9 µM -0.549239502524149 0.282577391344706 no 2397 0.291420549251444 791 67273
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.550029735349519 0.282296833660259 no 2398 0.291149489316341 772 641818 YHR062C RPP1
SGTC_3112 9123419 49.47 µM -0.550303456008229 0.282199685418579 no 2399 0.291055627100717 802 17015854
SGTC_35 0133-0054 64.071 µM -0.550304203342183 0.282199420198737 no 2400 0.291055370849966 784 99677
SGTC_531 3788-1495 174 µM -0.550430806006971 0.282154492165749 no 2401 0.291011962022008 747 2896655
SGTC_1360 1598-0022 39.8 µM -0.550573101253443 0.282103999349045 no 2402 0.290963176218184 800 761525
SGTC_1163 k060-0048 49.9 µM -0.551028227853783 0.281942528976092 no 2403 0.290807162116668 762 6809982
SGTC_1473 k844-0725 134 µM -0.55112313537491 0.281908863180443 no 2404 0.290774633434813 779 54682906
SGTC_1237 0330-0133 46.1 µM -0.552834623723758 0.281302093039473 no 2405 0.290188328693616 793 X1237 YHR072W ERG7
SGTC_1488 4013-0813 75.9 µM -0.552855256520041 0.281294781988011 no 2406 0.290181263894618 768 2910057
SGTC_3292 9120825 59.784 µM -0.553030932811775 0.281232536341597 no 2407 0.290121114493677 797 24824900
SGTC_377 3970-0964 33.1 µM -0.553547835594701 0.281049425864244 no 2408 0.28994416723691 777 16481235
SGTC_415 dibenzyl ketone 100 µM -0.555111842589082 0.280495734529289 no 2409 0.289409081492412 790 7593
SGTC_829 1635-0120 117 µM -0.555208928784407 0.280461381388338 no 2410 0.289375881185005 793 285054
SGTC_67 0335-0847 266 µM -0.555246115098318 0.280448223860588 no 2411 0.289363165154345 791 4552207 YOR254C SEC63
SGTC_1791 st048313 56.1 µM -0.555746395611709 0.280271240086508 no 2412 0.289192117468432 774 1204976
SGTC_1766 st045414 44.774 µM -0.558080635361614 0.27944617409773 no 2413 0.288394661591421 797 253960
SGTC_2433 5607874 27.82 µM -0.558712513448933 0.279223032005807 no 2414 0.288178968922826 779 2252428
SGTC_3163 9099914 49.47 µM -0.560713786828273 0.278516872257042 no 2415 0.287496333524242 796 16268368
SGTC_2192 5915882 198.485 µM -0.56146081109611 0.278253504007593 no 2416 0.287241719276966 775 2876149
SGTC_1131 3454-3128 32.3 µM -0.562186207259385 0.277997877141894 no 2417 0.286994578885471 769 710982
SGTC_796 1234-0020 70.7 µM -0.563982113025618 0.2773655002144 no 2418 0.286383152681128 758 46495034
SGTC_248 streptozotocin 5.23457 mM -0.564201944763059 0.27728814109009 no 2419 0.286308352225159 810 5300 DNA alkylating agent.
SGTC_1688 st021091 57.6 µM -0.564946993187089 0.277026035923768 no 2420 0.286054909337988 805 3656366
SGTC_3221 9128209 49.47 µM -0.565143737885552 0.276956842142284 no 2421 0.285988000552947 795 16460723
SGTC_2227 7312221 64.1025 µM -0.565881193015632 0.276697559477977 no 2422 0.285737273596805 800 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3223 9129970 49.47 µM -0.565922003889525 0.276683214211655 no 2423 0.285723401384561 778 17248386
SGTC_1438 4092-1045 4 µM -0.566844265817587 0.276359130837367 no 2424 0.285409996540887 792 1351342
SGTC_1084 voriconazole 435 nM -0.566979829050182 0.276311509540561 no 2425 0.285363942982858 807 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_758 0868-0029 16 µM -0.567452442470271 0.276145519141615 no 2426 0.28520341437821 761 762687
SGTC_528 3492-0019 172 µM -0.567619662453914 0.276086800177825 no 2427 0.28514662648851 782 2869262
SGTC_3219 9131112 49.47 µM -0.567958451795754 0.275967853769905 no 2428 0.285031590185076 781 17612988 YMR079W SEC14
SGTC_3146 9095609 49.47 µM -0.569570638564601 0.275402172134578 no 2429 0.284484473762826 786 17173999
SGTC_2821 7996764 71.43 µM -0.570440238105346 0.275097285415606 no 2430 0.284189572336237 743 2987135
SGTC_3114 9122766 49.47 µM -0.571795481699634 0.274622460687756 no 2431 0.283730269345962 762 17176985
SGTC_2419 paclitaxel 166.5 µM -0.573531140146073 0.274014944339159 no 2432 0.283142560375592 794 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2361 9034121 116 µM -0.573551358097815 0.274007871553148 no 2433 0.283135717845263 811 6496917
SGTC_139 0099-0334 718.624 µM -0.573616066530828 0.273985235400695 no 2434 0.283113818563011 791 97690
SGTC_3052 9092717 49.47 µM -0.576879161379059 0.272844947103095 no 2435 0.282010544316521 813 25237534
SGTC_617 3770-0098 35 µM -0.57693297137129 0.272826162951352 no 2436 0.281992368165685 793 5962639
SGTC_2172 5754775 163.918 µM -0.577300227028053 0.272697977389075 no 2437 0.281868330174839 772 2263357
SGTC_3130 9127414 49.47 µM -0.578623551667204 0.272236337040227 no 2438 0.281421604831866 800 1494646
SGTC_414 piperonyl butoxide 100 µM -0.578812677447763 0.272170392451294 no 2439 0.281357788034515 787 5794 A potent inhibitor of cytochrome P450.
SGTC_206 4546-0025 72.014 µM -0.579380940360436 0.271972297684832 no 2440 0.281166080857744 820 6620745 YIL048W NEO1
SGTC_3230 9131665 49.47 µM -0.581070236032053 0.271383837992331 no 2441 0.280596558819304 785 15943720
SGTC_2473 5854593 8.94 µM -0.581787199203337 0.271134278519416 no 2442 0.280355013708457 802 2872951
SGTC_2038 4100038 30.985 µM -0.581926017317646 0.271085972143999 no 2443 0.280308257480926 780 3596803
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.583240327941734 0.270628826903912 no 2444 0.279865763257639 828 6728940
SGTC_1746 st038117 42 µM -0.584110634135557 0.270326327899393 no 2445 0.279572940351886 786 2898218
SGTC_1550 gossypolone 36.6 µM -0.585886896170309 0.269709463875572 no 2446 0.278975761855595 783 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2267 7931562 200 µM -0.586217157457774 0.269594847818076 no 2447 0.278864796604832 771 934880
SGTC_1839 st053978 48 µM -0.589504106923389 0.268455454962118 no 2448 0.277761578971353 794 3788398
SGTC_985 1493-0307 8.71 µM -0.589680879178377 0.268394247051474 no 2449 0.277702308334476 798 3278274
SGTC_212 3807-4682 38.772 µM -0.591843389293713 0.267646040117735 no 2450 0.276977732587686 791 3125501 YBL034C STU1
SGTC_398 bronopol 33.3 µM -0.592993924816324 0.267248395207877 no 2451 0.276592609002529 789 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_291 SEC14.278 35.5 µM -0.593597112057092 0.267040042489491 no 2452 0.276390806535135 791 1068044
SGTC_3268 9137683 49.47 µM -0.59431086696361 0.266793603529746 no 2453 0.276152105846697 845 1953228
SGTC_128 0906-2981 13.371 µM -0.596482840273395 0.266044391527949 no 2454 0.275426356991185 805 6740226
SGTC_2952 9073731 13.78 µM -0.597354081920937 0.265744160553226 no 2455 0.275135501951654 810 16457353
SGTC_3312 9133330 71.43 µM -0.598319871380335 0.26541154913285 no 2456 0.274813259964558 821 17617324
SGTC_1187 1391-0724 117 µM -0.598506147114867 0.265347421328785 no 2457 0.274751129252751 796 6997986
SGTC_3197 9113331 49.47 µM -0.59940022545759 0.26503973292424 no 2458 0.274453013337337 780 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2701 st077767 14.721 µM -0.600730734061668 0.264582187081299 no 2459 0.274009672576227 784 5721188
SGTC_86 0417-1630 471.922 µM -0.602396643054906 0.264009868180984 no 2460 0.273455072010836 799 3634867
SGTC_863 0466-0191 129 µM -0.602414423111098 0.264003763291119 no 2461 0.273449155820934 809 765160 YPR165W RHO1
SGTC_2465 5809242 33.21 µM -0.604876434403537 0.263159112067589 no 2462 0.27263055112723 835 2731748
SGTC_378 3970-0959 8.33 µM -0.606358910019284 0.262651180516021 no 2463 0.272138223842089 812 6615653
SGTC_2783 7738165 71.43 µM -0.607030429429734 0.262421267113674 no 2464 0.271915359074212 803 17201110
SGTC_934 2950-0684 338 µM -0.608077325001562 0.262063038874425 no 2465 0.271568095161358 807 1121253
SGTC_549 1661-1316 519 µM -0.608426627719766 0.261943569757168 no 2466 0.271452277720712 820 2857282
SGTC_629 3448-6466 76.7 µM -0.608822314957883 0.261808269868897 no 2467 0.271321110410487 819 573744
SGTC_1806 st050005 60.3 µM -0.60889829610019 0.261782293250356 no 2468 0.271295926855219 785 5194765
SGTC_321 4534-3890 65.3 µM -0.6089154409173 0.261776431921237 no 2469 0.271290244455677 803 699746
SGTC_1822 st052468 42 µM -0.609549361592868 0.261559759606218 no 2470 0.271080182350464 797 2873678
SGTC_3050 9093513 49.47 µM -0.609770215911374 0.261484293846748 no 2471 0.271007016979967 812 25236664
SGTC_2773 thioridazine 9.09 µM -0.610324112743182 0.261295076893198 no 2472 0.270823563497714 806 5452 An antipsychotic.
SGTC_2264 7948757 110.76 µM -0.610451947466982 0.26125141720638 no 2473 0.270781232784555 800 2971411
SGTC_88 0180-0332 8.668 µM -0.611778738972586 0.260798496491191 no 2474 0.270342079137838 779 3101745
SGTC_7 0192-1582 4.227 µM -0.611863000730344 0.260769746090811 no 2475 0.270314201434783 825 252616
SGTC_1286 0929-0070 131 µM -0.611937206414634 0.26074442820764 no 2476 0.270289651938078 803 1420408
SGTC_1411 3909-8223 150 µM -0.612155832191252 0.260669843676003 no 2477 0.270217330364075 811 X1411
SGTC_1048 3161-0300 24.5 µM -0.613488166935828 0.260215553027675 no 2478 0.269776802302041 783 2165101
SGTC_3102 9121669 49.47 µM -0.614289744765925 0.259942433063634 no 2479 0.269511939040684 811 41905072
SGTC_2671 danthron 100 µM -0.615796102019515 0.25942957535091 no 2480 0.269014550193141 801 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2332 7982454 138.89 µM -0.615965587249667 0.259371904764772 no 2481 0.268958616180852 826 2981748
SGTC_76 0433-0009 400.328 µM -0.616196861524646 0.259293219962859 no 2482 0.268882299787306 830 2841569
SGTC_2314 7727897 200 µM -0.617446525947586 0.258868269018566 no 2483 0.268470120978086 786 900724
SGTC_2937 9044753 11.33 µM -0.617643452915077 0.258801336480861 no 2484 0.268405197228668 782 6465530 YGL099W LSG1
SGTC_2824 7998404 51.95 µM -0.618755708844022 0.258423465494335 no 2485 0.268038652090321 824 837851
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.620049005689233 0.257984448451807 no 2486 0.267612761827177 782 3256 An antibiotic and ribosome inhibitor.
SGTC_2126 5251174 33.877 µM -0.621093213879756 0.257630268471875 no 2487 0.267269146996266 801 790722
SGTC_1393 3470-5649 58.2 µM -0.624404963920787 0.256508644309342 no 2488 0.266180832967527 793 4108395
SGTC_29 0299-0004 12.984 µM -0.624608484341365 0.25643979903424 no 2489 0.266114024923813 800 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1740 st038286 13.222 µM -0.626257344206339 0.255882390953387 no 2490 0.265573079945597 791 716786
SGTC_2933 9026794 32.47 µM -0.627217202674115 0.255558195817693 no 2491 0.265258434170454 802 17586027
SGTC_1963 st076565 50.3 µM -0.627328854303476 0.255520499073276 no 2492 0.265221846573132 826 4914280
SGTC_2643 anethole 100 µM -0.628127220778815 0.255251032669853 no 2493 0.264960301157896 839 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_525 k781-2675 26.7 µM -0.628586361708562 0.255096129734721 no 2494 0.26480994565154 796 3651118 YDL195W SEC31
SGTC_1 0258-0098 57.368 µM -0.629090193302101 0.254926205859886 no 2495 0.264645005161371 783 6790032 YDR047W HEM12
SGTC_1234 0326-0494 15.5 µM -0.629591114500871 0.254757322293265 no 2496 0.264481069272154 826 1547813
SGTC_390 dec-rvkr-cmk 16.7 µM -0.62975524096949 0.254702000458067 no 2497 0.264427367038726 791 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1641 st009299 47.1 µM -0.631862560813823 0.253992248969727 no 2498 0.263738344747313 801 4046054
SGTC_3264 9137442 49.47 µM -0.635645370057769 0.252720795897818 no 2499 0.262503795421 805 17015726
SGTC_3184 9108758 49.47 µM -0.63565155130681 0.252718721043175 no 2500 0.262501780545624 819 902885
SGTC_2610 ononetin 44.17 µM -0.636197017909121 0.252535660058676 no 2501 0.262324008303752 800 259632
SGTC_1433 4060-0023 7.6 µM -0.63687950165089 0.25230671395203 no 2502 0.262101667872288 809 3840627
SGTC_2388 9080168 200 µM -0.637243619207336 0.252184611797388 no 2503 0.261983084708281 830 15943073
SGTC_1056 3448-1962 115 µM -0.637442179606704 0.252118040246141 no 2504 0.261918430589449 804 715507
SGTC_3192 9110362 49.47 µM -0.637805519580424 0.251996246881193 no 2505 0.261800143061345 825 16649480
SGTC_579 4491-1009 110 µM -0.638571145718808 0.251739706865981 no 2506 0.261550978576781 840 1271041
SGTC_980 1473-0395 201 µM -0.640262511568453 0.25117346644416 no 2507 0.261000974256905 827 768876
SGTC_3176 9106582 49.47 µM -0.641105310926348 0.25089156326991 no 2508 0.260727131946201 781 17018027
SGTC_3188 9110789 49.47 µM -0.641346761439473 0.250810832730526 no 2509 0.260648707116066 821 849217
SGTC_435 c-PAF 6.7 µM -0.641542823000683 0.250745288399955 no 2510 0.260585033871436 803 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1013 4112-3890 241 µM -0.642281085149747 0.250498565184352 no 2511 0.260345346620579 816 705171
SGTC_3180 9109287 49.47 µM -0.643815894884674 0.249986052070726 no 2512 0.259847412674354 807 18891271
SGTC_2924 9010168 62.78 µM -0.644959856629384 0.249604415560487 no 2513 0.259476600265158 815 2993929
SGTC_3227 9130768 49.47 µM -0.645423179247183 0.249449934838097 no 2514 0.259326493167412 823 17720899
SGTC_332 4112-0506 40.9 µM -0.646102716039933 0.249223456070204 no 2515 0.259106418267572 827 2790355
SGTC_150 3970-0969 77.2 µM -0.646233991178963 0.2491797167672 no 2516 0.259063914610781 834 6615640
SGTC_1930 st074634 34.3 µM -0.648314754972352 0.248486976756344 no 2517 0.258390696328918 823 684253 YOR116C RPO31
SGTC_211 3455-0679 143.504 µM -0.650210299488485 0.247856795417978 no 2518 0.257778194526335 788 748649
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.650679499687316 0.247700939762381 no 2519 0.257626699663098 841 688798
SGTC_689 0833-0039 98 µM -0.652229853872557 0.247186326296161 no 2520 0.257126451900135 859 5374726
SGTC_1305 1181-0477 144 µM -0.652326313205475 0.247154327180059 no 2521 0.257095344379331 829 6252086
SGTC_3123 9126162 49.47 µM -0.655513204358498 0.246098364799345 no 2522 0.256068693859729 800 25239884
SGTC_464 bw-b 70c 158 µM -0.656625060438222 0.245730526399382 no 2523 0.255711015507195 834 5353454
SGTC_669 0108-0021 26.2 µM -0.658480947085163 0.245117196517562 no 2524 0.255114567993871 859 17201
SGTC_223 busulfan 5 mM -0.659476977825549 0.24478836999407 no 2525 0.254794762516456 815 2478 A DNA alkylator.
SGTC_1679 SEC14.276 6.7 µM -0.659949161792712 0.244632567640242 no 2526 0.254643227085562 820 1005053 YMR079W SEC14
SGTC_802 4112-3352 742 µM -0.660252346187901 0.244532556735931 no 2527 0.254545952656716 793 704594
SGTC_1696 st025591 34.7925 µM -0.660692582535693 0.244387375962319 no 2528 0.254404740804475 818 2787147
SGTC_1684 st024538 14.6195 µM -0.662063183320846 0.2439356779583 no 2529 0.253965364811404 821 6732859
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.663992697022408 0.243300547667545 no 2530 0.253347492613115 814 688664
SGTC_2607 solasodine 47.35 µM -0.666068712445931 0.242618193367732 no 2531 0.252683590896602 834 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_653 0203-0016 55.2 µM -0.666521957707279 0.242469356562565 no 2532 0.252538766765111 827 295302
SGTC_856 0433-0016 11.3 µM -0.667094293358427 0.242281483503728 no 2533 0.252355952527353 819 3911780
SGTC_949 1165-0505 146 µM -0.668677575020736 0.241762171811338 no 2534 0.251850587713625 824 6244267
SGTC_536 3852-0578 10.6 µM -0.6691713202217 0.241600348504902 no 2535 0.251693099424699 829 2869208
SGTC_3088 9117578 49.47 µM -0.670123094313224 0.241288573811808 no 2536 0.251389661984112 833 678341
SGTC_1817 st052116 64.4 µM -0.671603222101585 0.240804159839896 no 2537 0.250918163241827 817 4361398
SGTC_225 nsc-122657 1.016 µM -0.671860621249532 0.240719972683632 no 2538 0.250836215843066 828 275685
SGTC_2724 maprotiline 69.64 µM -0.6719131769899 0.240702785325246 no 2539 0.250819485570753 827 4011 A tricyclic antidepressant.
SGTC_2413 inermin 26.06 µM -0.672429420748968 0.240533993099762 no 2540 0.250655179103222 838 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_118 0083-0097 135.343 µM -0.672594622251347 0.240479992058825 no 2541 0.250602611963101 857 5207356
SGTC_2090 5301565 104.445 µM -0.67370029410102 0.240118740243006 no 2542 0.250250937429769 819 2056344
SGTC_2611 pyromycin 23.93 µM -0.673990617143612 0.240023933195393 no 2543 0.250158639486437 820 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.674387852533193 0.239894246238024 no 2544 0.250032381802792 833 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2452 5863136 48.41 µM -0.674800146338109 0.239759683531907 no 2545 0.249901373703908 820 2184096
SGTC_1706 st031321 9.9705 µM -0.674871431752129 0.239736421876965 no 2546 0.249878726157264 820 6103185
SGTC_3242 9133940 49.47 µM -0.674915285972095 0.239722112103638 no 2547 0.249864794107918 824 17248444
SGTC_1323 1348-1351 11.2 µM -0.675550097208233 0.239515023365966 no 2548 0.249663167088413 817 6989654
SGTC_345 1362-0200 395 µM -0.679212351277318 0.238322228605363 no 2549 0.248501661218889 827 1419823
SGTC_1453 4237-0541 195 µM -0.679571313770299 0.23820548998879 no 2550 0.248387969252789 815 739892
SGTC_1578 josamycin 24.2 µM -0.68024449908329 0.237986647091437 no 2551 0.248174830213067 821 5282165 A P450 substrate.
SGTC_2022 5136654 200 µM -0.680800276605154 0.237806054875566 no 2552 0.247998937508965 841 1713771
SGTC_17 0960-0276 49.807 µM -0.682891059516354 0.237127357577099 no 2553 0.24733784189142 828 6821114
SGTC_2833 9001315 45.46 µM -0.683327810641285 0.236985716567264 no 2554 0.247199862306741 822 2989378
SGTC_2411 st077133 39.94 µM -0.683714357888885 0.236860395777322 no 2555 0.24707777761085 841 1403142 YNL221C POP1
SGTC_826 1683-5028 118 µM -0.684254093746183 0.236685471354334 no 2556 0.246907364744809 829 722377
SGTC_3155 9099265 49.47 µM -0.684275373442474 0.236678576217572 no 2557 0.246900647314101 829 25236499
SGTC_3079 9117512 49.47 µM -0.685413713488248 0.236309887581638 no 2558 0.246541446431407 878 7185044
SGTC_2734 clemastine 41.6 µM -0.686527958923833 0.235949309248333 no 2559 0.246190119871599 866 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2630 antimycin a 100 µM -0.686887934964796 0.235832883091199 no 2560 0.246076675223264 844 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2487 5918373 44.05 µM -0.687714445370478 0.235565686762789 no 2561 0.245816310743131 832 2876279
SGTC_682 0kpi-0099 17 µM -0.68875456742363 0.235229671000307 no 2562 0.245488865311826 846 1714895 YML126C ERG13
SGTC_2950 9072895 21.46 µM -0.689755677431635 0.234906508348464 no 2563 0.245173922899418 809 17332245
SGTC_3009 9080819 71.4286 µM -0.690039232434128 0.234815020172067 no 2564 0.245084757922008 829 17027216
SGTC_2731 amoxapine 43.43 µM -0.691036370747173 0.234493452931787 no 2565 0.244771342446856 866 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_762 1165-0429 115 µM -0.691120441543535 0.234466352072301 no 2566 0.244744927605028 830 5967793
SGTC_2213 7173844 200 µM -0.693659171448304 0.233648789972529 no 2567 0.243947988155926 833 892728
SGTC_942 3253-1115 227 µM -0.694418714479196 0.233404497399423 no 2568 0.243709830373721 861 46497897
SGTC_1708 st033234 31.827 µM -0.695814939621863 0.232955798017914 no 2569 0.243272366000216 813 674664
SGTC_1953 st076800 12.1 µM -0.69628254327881 0.232805633234881 no 2570 0.243125951654425 826 297591
SGTC_2564 betulinic acid 100 µM -0.696416266228991 0.232762699754747 no 2571 0.243084089577015 845 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3113 9123498 49.47 µM -0.697846806774716 0.232303681642033 no 2572 0.242636501701096 854 8897275
SGTC_257 daunorubicin 18.5 µM -0.697877161140095 0.2322939472843 no 2573 0.242627009256902 827 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1485 3909-9022 254 µM -0.698167499997928 0.232200849827876 no 2574 0.242536224391226 843 714516
SGTC_1236 0330-0013 258 µM -0.698167741970201 0.232200772247876 no 2575 0.242536148737583 840 4617066
SGTC_638 3970-0837 4.09 µM -0.698544372278144 0.23208003631456 no 2576 0.242418409189738 830 4118451 YLR208W SEC13
SGTC_1416 3966-0321 25.3 µM -0.701081316690217 0.231267682205552 no 2577 0.241626134652422 833 582530 YLR208W SEC13
SGTC_555 4296-0685 37 µM -0.701398225671513 0.23116631645547 no 2578 0.241527264493457 850 2908540 YHR072W ERG7
SGTC_2700 st077718 96.8 µM -0.702090662520784 0.230944921541899 no 2579 0.241311312557164 836 904970
SGTC_1604 st002052 72.4 µM -0.70227423959067 0.230886245752695 no 2580 0.241254077537239 823 6254834 YHR062C RPP1
SGTC_870 0573-2213 57.6 µM -0.702411816321919 0.230842278271048 no 2581 0.241211189179453 819 3916321
SGTC_678 1218-2179 85.9 µM -0.702744789786611 0.230735884248221 no 2582 0.241107404731787 861 6820081 YOR116C RPO31
SGTC_2163 5671233 125 µM -0.704700314757394 0.230111594283361 no 2583 0.240498377711688 830 701023
SGTC_2778 tioconazole 65.09 nM -0.705876137220777 0.229736675220922 no 2584 0.240132584255214 845 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_12 0849-0099 9.267 µM -0.707050984687638 0.229362408951334 no 2585 0.239767397215748 838 6071388
SGTC_2159 5658611 73.75 µM -0.707430292913261 0.229241647333944 no 2586 0.239649558610277 843 793844
SGTC_2949 9072542 2.23 µM -0.708823205902426 0.228798486995604 no 2587 0.239217097593022 859 16457352
SGTC_2343 7990716 14.84 µM -0.709486465040128 0.228587637819884 no 2588 0.239011323910271 856 6456862
SGTC_2556 citropten 84.59 µM -0.709952068172256 0.228439688438026 no 2589 0.238866930099031 803 2775 A potential DNA crosslinker.
SGTC_131 0141-0277 33.849 µM -0.711344925443828 0.22799741748612 no 2590 0.238435259285903 852 1547771
SGTC_129 0088-0017 176.636 µM -0.711438991686039 0.227967566207962 no 2591 0.23840612191873 833 182446
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.711891253791281 0.227824074624754 no 2592 0.238266059281723 839 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3325 9138760 55.175 µM -0.712108120535597 0.227755286202335 no 2593 0.238198913052155 828 43844959
SGTC_751 0833-0568 350 µM -0.712406264324534 0.227660736427164 no 2594 0.238106618769712 843 6954252
SGTC_1776 st049249 45.9 µM -0.713754639698058 0.227233404758626 no 2595 0.237689456499312 842 1822314
SGTC_1837 st055472 66.5 µM -0.714396302336001 0.227030205727048 no 2596 0.237491078906555 831 676091
SGTC_1843 st055809 45.5 µM -0.715044145782186 0.226825153365759 no 2597 0.237290882677529 841 16413835
SGTC_56 0957-0365 83.25 µM -0.715275380152161 0.226751989459751 no 2598 0.237219449208942 836 6752360
SGTC_2170 morpholine 200 µM -0.715874071280106 0.226562621971824 no 2599 0.23703455502469 833 121171 Reacts with secondary amines.
SGTC_2972 9093619 59.92 µM -0.715903775749819 0.226553228699646 no 2600 0.237025383435987 822 25236256
SGTC_901 1112-0062 60.1 µM -0.717746089383182 0.225971074380708 no 2601 0.236456929731015 839 1908457
SGTC_2406 ethylparaben 405.7 µM -0.718333966132409 0.225785488830016 no 2602 0.236275695908464 840 8434 A possible steroid mimic.
SGTC_1938 st074717 56.4 µM -0.718730588639076 0.225660328638901 no 2603 0.236153466202486 813 17250979
SGTC_2580 diallyl disulphide 81.36 µM -0.718897184878634 0.225607768401924 no 2604 0.236102135558518 836 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_27 0485-0001 32.618 µM -0.720158364922953 0.225210097531592 no 2605 0.23571374771767 828 2054479
SGTC_2403 6032726 181.2 µM -0.720553625286854 0.22508554718512 no 2606 0.23559209750947 847 2881040
SGTC_1996 st072960 66.8 µM -0.721804230656362 0.224691726596533 no 2607 0.235207424010018 829 1719405
SGTC_707 0865-0008 204 µM -0.723266529469046 0.224231738927774 no 2608 0.234758075965561 857 723043
SGTC_1782 st039423 80.636 µM -0.723645749733091 0.224112536968656 no 2609 0.234641623370731 841 2068169
SGTC_2384 9036245 200 µM -0.724569675754751 0.223822265991215 no 2610 0.234358033957126 817 6462766
SGTC_3030 9087619 49.47 µM -0.725933902304003 0.223394056213238 no 2611 0.233939645942031 832 25236973
SGTC_3131 9127911 49.47 µM -0.727158803751601 0.223009975922811 no 2612 0.233564339712602 829 45595681
SGTC_3006 9075424 71.4286 µM -0.727517660003319 0.222897524171222 no 2613 0.233454450477182 844 7465181
SGTC_1178 0988-0033 191 µM -0.730683980348632 0.221906722110105 no 2614 0.232486101354253 842 5392207
SGTC_919 tnp00227 403.569 nM -0.730692463131958 0.2219040710679 no 2615 0.232483510085955 874 1269246 A methoxyflavone. YNL221C POP1
SGTC_3011 9081274 71.4286 µM -0.731329292741445 0.221705100524688 no 2616 0.232289021177041 852 6625322
SGTC_1756 st041558 35.5 µM -0.731747059666235 0.22157462914254 no 2617 0.232161483593681 871 3955792
SGTC_1731 st035964 63 µM -0.732657604516593 0.221290412054453 no 2618 0.23188364385158 885 6739575
SGTC_1124 fisetin 1.16336 µM -0.732696725638361 0.221278205477461 no 2619 0.23187171075133 849 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1296 1068-0102 11.9 µM -0.736211927818954 0.220182964704255 no 2620 0.230800867210695 839 767053
SGTC_1902 st060212 70.5 µM -0.736248470768248 0.220171595273265 no 2621 0.230789749579152 835 688944
SGTC_215 1287-0124 461.5 µM -0.736634207675456 0.220051603352192 no 2622 0.23067241328857 849 5560863
SGTC_1354 1498-1681 81 µM -0.738180862209365 0.219570859497902 no 2623 0.230202275416229 848 5754243
SGTC_1050 3232-1156 69.3 µM -0.738915843879324 0.219342618067295 no 2624 0.229979050427315 858 700529
SGTC_1000 4048-0884 8.67 µM -0.739091377521596 0.219288127973094 no 2625 0.229925756146891 854 13040088
SGTC_3278 9139605 49.47 µM -0.739776187206141 0.219075620077709 no 2626 0.229717905190806 857 7958859
SGTC_2071 5230951 39.92 µM -0.740519201566644 0.218845184301742 no 2627 0.229492507236912 861 1799272
SGTC_3291 9121177 71.43 µM -0.741147634238577 0.218650393378377 no 2628 0.229301965115458 859 17015612
SGTC_69 0096-0274 206.684 µM -0.74341200899243 0.217949349054705 no 2629 0.228616137945586 872 6741392
SGTC_1564 D-Arginine 115 µM -0.744023288809757 0.217760320869804 no 2630 0.228431192977745 858 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_823 0417-1665 178 µM -0.744500859181701 0.217612705951427 no 2631 0.228286760809992 872 3429856
SGTC_3038 9091290 49.47 µM -0.74669885183898 0.216934060925551 no 2632 0.227622681490469 848 25236843
SGTC_477 mead ethanolamide 10 µM -0.746872031521729 0.216880642573434 no 2633 0.227570404992399 807 16061185
SGTC_1662 st014054 52 µM -0.747203706350354 0.216778356636763 no 2634 0.22747030358631 851 2838777
SGTC_2444 5485484 36.41 µM -0.748699923308846 0.216317281848313 no 2635 0.227019044953297 881 6790631
SGTC_1264 0783-0040 158 µM -0.750410868285205 0.215790732787882 no 2636 0.226503643621469 856 2855798
SGTC_1370 2001-0092 44.6 µM -0.751106603211179 0.215576830671616 no 2637 0.226294251043685 848 790957
SGTC_2713 st079149 53.4 µM -0.751210901970321 0.215544774857341 no 2638 0.226262870088199 847 3103253
SGTC_3036 9090181 49.47 µM -0.753356177781265 0.214886046198304 no 2639 0.225617954441675 867 25236586
SGTC_2871 9038510 12.99 µM -0.754013926281001 0.214684312332293 no 2640 0.2254204297655 867 4945164
SGTC_3193 9111931 49.47 µM -0.754092758379126 0.214660141628144 no 2641 0.225396762722357 895 17087244
SGTC_190 3970-0790 3.722 µM -0.754515716842819 0.214530485372267 no 2642 0.22526980577881 847 2832352
SGTC_201 4262-0159 12.803 µM -0.75521592715701 0.214315938755312 no 2643 0.225059716833076 860 1341029
SGTC_2110 5483698 200 µM -0.755824295937205 0.214129634031284 no 2644 0.224877273907933 833 2848765 YHR062C RPP1
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.756400747794708 0.213953190421266 no 2645 0.224704479893687 890 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1221 2958-7315 257 µM -0.757429113180017 0.213638632857283 no 2646 0.224396409854209 857 4562705
SGTC_2856 9022925 19.48 µM -0.757552816219037 0.213600812594868 no 2647 0.224359367979097 843 4944862
SGTC_3143 9086658 49.47 µM -0.757857900643687 0.213507554496745 no 2648 0.224268027751411 866 25236626
SGTC_586 0957-0265 8.15 µM -0.758234322567862 0.213392522683139 no 2649 0.224155358655982 852 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1146 3579-1023 7 µM -0.758761045483539 0.213231620635734 no 2650 0.223997756047728 876 X1146
SGTC_1851 st056236 18.9 µM -0.758923399910584 0.213182039264831 no 2651 0.223949190107175 825 5393171
SGTC_1986 st071812 45 µM -0.759533891428751 0.212995661626408 no 2652 0.223766624099739 857 11838594
SGTC_3015 9080845 49.47 µM -0.759680117433 0.212951034243457 no 2653 0.223722908130464 855 5296973
SGTC_281 1672-3440 14.9 µM -0.761232623889393 0.212477554300625 no 2654 0.223259067765915 852 6833000
SGTC_636 0kpi-0074 126 µM -0.762481421438054 0.212097145520376 no 2655 0.222886363674467 863 616434
SGTC_1077 5-fluorocytosine 377 nM -0.763704729167691 0.211724887856489 no 2656 0.222521610955147 876 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2222 6885208 172.143 µM -0.765062885730462 0.211312043377496 no 2657 0.222117049471935 852 609514
SGTC_1760 st045453 10.4495 µM -0.765964192117626 0.211038330046023 no 2658 0.221848804344844 857 3323419 YIL048W NEO1
SGTC_699 0375-0592 111 µM -0.769893163710137 0.209847589874821 no 2659 0.220681634729194 817 762578
SGTC_3245 9134821 49.47 µM -0.770639225373343 0.209621930461548 no 2660 0.220460402113564 879 17014901
SGTC_596 1155-0152 116 µM -0.771645981671031 0.2093176457324 no 2661 0.22016206626892 852 280313
SGTC_2775 cyproheptadine 69.59 µM -0.773859331147425 0.208649591741434 no 2662 0.219506990898802 847 2913 A selective serotonin reuptake inhibitor.
SGTC_369 0957-0393 4.5 µM -0.773956283856768 0.208620357322265 no 2663 0.219478321848722 866 6997992
SGTC_688 0527-0193 473 µM -0.775229687044076 0.20823660871342 no 2664 0.219101974482296 890 4007154
SGTC_631 k072-0230 41.5 µM -0.77535030109942 0.208200282462792 no 2665 0.219066346904265 881 5773147
SGTC_2259 7964009 200 µM -0.776969465766509 0.207712988488747 no 2666 0.218588392662837 855 313134
SGTC_1993 st073995 70.8 µM -0.777835635783108 0.207452588065486 no 2667 0.21833295834469 866 3098394
SGTC_5 0352-0601 109.883 µM -0.778211715847026 0.207339585602815 no 2668 0.218222105555113 852 762456
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.779648592368167 0.20690817615483 no 2669 0.217798872792201 859 2724 A muscle relaxant with antifungal properties.
SGTC_1714 st033236 13.627 µM -0.781998477841861 0.206203789830834 no 2670 0.217107734075169 879 2916566
SGTC_1447 4239-0816 81.9 µM -0.78288015587842 0.205939870952375 no 2671 0.216848745807163 854 1341554
SGTC_469 w7 172 µM -0.784277788002725 0.205521918707972 no 2672 0.216438564950341 855 45115570 A P450 inhibitor.
SGTC_1815 st051655 58.2 µM -0.7843019521731 0.205514697011295 no 2673 0.216431477135149 867 5984156
SGTC_3072 9116419 49.47 µM -0.78554875040225 0.205142283750794 no 2674 0.216065949580246 863 17170162
SGTC_1009 4106-0057 9.87 µM -0.786172905748349 0.204956001966204 no 2675 0.215883098485902 853 2928005
SGTC_351 caspofungin 25 nM -0.787882029015847 0.204446421931204 no 2676 0.21538285692067 845 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2730 imipramine 71.33 µM -0.789213136020676 0.204050071398628 no 2677 0.214993722824907 857 3696 A tricyclic antidepressant.
SGTC_2990 9074105 71.4286 µM -0.789432774405946 0.20398471588056 no 2678 0.21492955328814 882 6502001
SGTC_2210 7115885 190.385 µM -0.7913181599657 0.20342421447226 no 2679 0.214379176924574 872 2927039
SGTC_1477 0139-0234 16 µM -0.791433374785948 0.203389992371964 no 2680 0.214345570338833 866 620880
SGTC_2720 fluspirilene 36.88 µM -0.791584418458944 0.203345133280327 no 2681 0.214301517609081 889 3396 An atypical antipsychotic.
SGTC_2602 kawain 100 µM -0.793081213166283 0.202900913182409 no 2682 0.213865253844306 853 5369129
SGTC_187 1488-2104 32.728 µM -0.794980737401066 0.202338005988672 no 2683 0.21331235362641 853 2852859
SGTC_401 neomycin 50 µM -0.795095345838896 0.202304072695395 no 2684 0.213279020884552 841 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2091 4-phenylthiadiazole 200 µM -0.795680893800985 0.202130756643229 no 2685 0.213108767397441 871 270010
SGTC_2469 5655019 90.81 µM -0.795688343786883 0.202128552098115 no 2686 0.21310660175599 868 2788239
SGTC_605 1315-0399 119 µM -0.796085798601819 0.202010961046957 no 2687 0.212991083959085 878 24020461
SGTC_2124 5246320 200 µM -0.797264438096283 0.201662489382772 no 2688 0.212648734541261 874 579342
SGTC_1912 st060209 90.8 µM -0.801226157248978 0.200493825823809 no 2689 0.211500365434051 879 688787
SGTC_782 0083-0095 30.5 µM -0.80167438966453 0.20036185880578 no 2690 0.21137066699243 870 3591729 An indicator and reagent.
SGTC_2793 7325131 81.82 µM -0.801716754433804 0.200349388618439 no 2691 0.211358410930388 852 4176441
SGTC_2818 7996756 12.99 µM -0.801870105631425 0.200304253166846 no 2692 0.211314050147339 898 2241621
SGTC_1235 benzylparaben 21.5 µM -0.80337944604218 0.199860339067967 no 2693 0.210877725666815 879 7180
SGTC_1761 st044296 37 µM -0.803538822734207 0.199813499141601 no 2694 0.210831683451099 884 1826700
SGTC_1210 3013-0140 750 nM -0.803853997961107 0.199720890331408 no 2695 0.210740650069923 856 905973
SGTC_3020 9089140 49.47 µM -0.805420560963393 0.199260966066001 no 2696 0.210288515352382 885 17217859
SGTC_2146 5545642 200 µM -0.807368057090993 0.198690094582449 no 2697 0.209727232310059 869 825326
SGTC_1427 4048-4900 550 nM -0.807662854762133 0.198603766271501 no 2698 0.209642346230232 866 24132586
SGTC_2635 hydroquinidine 100 µM -0.807734104202315 0.198582905038242 no 2699 0.209621833206019 866 442912 An experimental heart treatment.
SGTC_2120 5538279 151.968 µM -0.808062458318136 0.198486782812981 no 2700 0.209527313882411 869 2058197
SGTC_1277 0873-0036 22 µM -0.808147780604034 0.198461810203454 no 2701 0.209502757293394 874 5965735
SGTC_566 0958-0068 16.5 µM -0.810043079675076 0.197907572199882 no 2702 0.208957708328886 862 6815365
SGTC_820 1582-0060 59.9 µM -0.810055644042761 0.197903901152776 no 2703 0.208954097864768 879 3848840
SGTC_2212 7123476 200 µM -0.810934454418093 0.19764723309542 no 2704 0.208701656377055 851 1085715
SGTC_214 4373-3496 70 µM -0.811830849092738 0.197385636698656 no 2705 0.208444349009584 880 3779166
SGTC_1842 st055362 61.2 µM -0.813094291629499 0.197017279853523 no 2706 0.208081999523797 861 676032
SGTC_1408 3909-7976 48.8 µM -0.813651715374694 0.196854895250113 no 2707 0.207922251239214 885 24152374
SGTC_1994 st072947 40.9 µM -0.81493809079949 0.196480467199696 no 2708 0.207553874138626 887 5286565 YDL195W SEC31
SGTC_2943 9068529 45.32 µM -0.815465615462759 0.196327044329371 no 2709 0.207402919399424 886 3270634
SGTC_2816 7982706 58.44 µM -0.815696474226491 0.19625992526942 no 2710 0.207336878029888 883 2981853
SGTC_677 0929-0063 136 µM -0.81583917032074 0.196218445270026 no 2711 0.207296063422142 903 1539583
SGTC_1489 4065-0444 182 µM -0.815840942251165 0.196217930225062 no 2712 0.207295556636136 856 2877968
SGTC_842 0271-0008 11.1 µM -0.817850979110196 0.195634203138104 no 2713 0.20672114223574 862 1221709
SGTC_403 arphamenine a 50 µM -0.821653040095004 0.194532948335535 no 2714 0.20563719646504 876 5487158 An arginine aminopeptidase inhibitor.
SGTC_1792 st045773 43.6 µM -0.821662500205262 0.19453021295875 no 2715 0.205634503656383 827 2919270
SGTC_3014 9081533 49.47 µM -0.821998284737878 0.194433136523673 no 2716 0.205538936562882 885 21367265
SGTC_715 0868-0130 184 µM -0.825779422192396 0.193342033837132 no 2717 0.204464614597964 914 2876258
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.826055416090616 0.193262538329273 no 2718 0.204386328469245 857 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1468 k284-1086 134 µM -0.826868251148788 0.19302853045942 no 2719 0.204155870134599 874 15996457
SGTC_2338 7999974 200 µM -0.829804084941107 0.19218477240739 no 2720 0.20332478043705 884 315925
SGTC_446 go6976 132 µM -0.829897852725207 0.192157860799961 no 2721 0.2032982695231 893 3501 A protein kinase C inhibitor.
SGTC_1633 st005664 67.9 µM -0.830739141995175 0.191916511654619 no 2722 0.203060504565052 900 2063822
SGTC_162 k030-0015 37.8 µM -0.832681339140853 0.191360043014732 no 2723 0.20251223579844 906 1809920 YMR134W ERG29
SGTC_909 3448-9333 149 µM -0.836023294225196 0.190404840276018 no 2724 0.201570899273434 894 3344074
SGTC_900 1112-0045 141 µM -0.836311639987564 0.190322562295729 no 2725 0.201489803262489 864 56211 YIL048W NEO1
SGTC_2453 5731132 22.18 µM -0.838103652835565 0.189811710405078 no 2726 0.200986245781579 903 1362040
SGTC_26 0302-0163 425.158 µM -0.838387172491499 0.189730964338857 no 2727 0.200906645690764 914 3100915
SGTC_1155 4088-0394 48.2 µM -0.84032644883078 0.189179227330455 no 2728 0.200362687899547 890 2326248
SGTC_2822 7994718 71.43 µM -0.840671525785252 0.189081154285017 no 2729 0.200265988263366 922 1018011
SGTC_516 3992-2719 87.3 µM -0.842210543142348 0.18864413722438 no 2730 0.199835056678075 907 5350887 YDR037W KRS1
SGTC_3347 9188721 44.724 µM -0.84389273341085 0.188167177905754 no 2731 0.199364674572582 880 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1390 3413-2614 145 µM -0.844940714299392 0.187870415523468 no 2732 0.199071970449348 913 3421432
SGTC_2812 7970281 58.44 µM -0.845484598733735 0.187716514825901 no 2733 0.198920164048056 912 2233435
SGTC_523 1934-0222 13.7 µM -0.846638309107099 0.187390312141435 no 2734 0.198598377027966 912 1361595
SGTC_703 3875-0075 71.8 µM -0.848301810142244 0.186920587379342 no 2735 0.19813495488199 914 2850814
SGTC_3185 9108267 49.47 µM -0.848420983209024 0.186886964328955 no 2736 0.198101780441449 885 4910486
SGTC_777 1315-0167 517 µM -0.849706742810732 0.186524442902713 no 2737 0.197744074349055 865 4221767
SGTC_2449 5812982 45.77 µM -0.851885192415256 0.185911221293847 no 2738 0.197138908086075 895 776185
SGTC_3178 9107506 49.47 µM -0.852917219513153 0.185621148253213 no 2739 0.196852605927954 878 8897194
SGTC_371 0195-0006 7.36 µM -0.853031329225412 0.185589092556631 no 2740 0.196820965385601 877 3928593
SGTC_259 usnic acid 108.925 µM -0.853742349040641 0.185389430291225 no 2741 0.196623881941849 905 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2236 dapsone 200 µM -0.854257029373863 0.185244985566208 no 2742 0.196481295314678 872 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1218 1348-1416 30.7 µM -0.855832366722867 0.184803302586031 no 2743 0.196045254679337 877 6787668
SGTC_2372 9071633 200 µM -0.858261489490264 0.184123524848341 no 2744 0.195374044612623 894 21321366
SGTC_2922 7999257 32.47 µM -0.858702528209934 0.184000269553528 no 2745 0.195252327639619 913 2988377
SGTC_1413 3910-0535 34.4 µM -0.858784530225733 0.18397735844931 no 2746 0.195229701970305 875 2876951
SGTC_2618 avocadyne 43.43 µM -0.860565190997245 0.183480285623402 no 2747 0.194738782160802 889 3015189
SGTC_804 1595-0054 20.9 µM -0.86090397459376 0.183385808794109 no 2748 0.194645466215228 893 761523 Stimulates phospholipase C.
SGTC_2836 9010338 19.48 µM -0.861676874294316 0.183170383240575 no 2749 0.194432677409923 901 2994051
SGTC_1864 st057645 30.4 µM -0.86336057497947 0.182701642491933 no 2750 0.193969624372141 897 688666
SGTC_1814 st052110 31.539 µM -0.864206431776489 0.182466439613617 no 2751 0.193737249809598 898 674163
SGTC_3044 9093193 49.47 µM -0.867359564912327 0.181591332516309 no 2752 0.192872514770585 869 25236277
SGTC_1699 st031318 29.054 µM -0.867628490878704 0.181516817709304 no 2753 0.192798872098195 891 5340658
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.867907156868906 0.181439624301459 no 2754 0.192722580343755 884 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1245 0418-0076 17.2 µM -0.868277355555868 0.181337107165044 no 2755 0.192621257769089 906 6790114
SGTC_696 1560-0013 611 µM -0.869501684160112 0.180998318811272 no 2756 0.192286393645877 879 1650269
SGTC_300 r073-0011 5.04 µM -0.870370256846006 0.180758213601517 no 2757 0.192049047777809 887 2735780
SGTC_1692 fluoroquinolonic acid 71 µM -0.870522400423822 0.180716176121844 no 2758 0.192007491536296 898 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_189 3970-0742 2.116 µM -0.8738199556862 0.179806563628388 no 2759 0.191108155530434 876 2891807
SGTC_1644 st010134 20.9 µM -0.874209861407372 0.179699200738594 no 2760 0.191001988309779 891 3818134
SGTC_724 3910-0327 137 µM -0.875259596765244 0.17941035003501 no 2761 0.190716336276238 899 2885483
SGTC_809 3998-0021 90 µM -0.881156522512287 0.177793151373784 no 2762 0.189116553920004 909 715485
SGTC_1205 4161-2785 76 µM -0.881165611445574 0.177790665904009 no 2763 0.189114094571191 911 3498106
SGTC_837 0091-0265 12.5 µM -0.886122434179083 0.17643843410421 no 2764 0.18777577761666 903 759367
SGTC_1359 1582-0056 520 nM -0.886537480248215 0.176325504603115 no 2765 0.187663983314733 908 3661189
SGTC_356 1634-0012 32.5 µM -0.886938088075452 0.176216546976351 no 2766 0.187556117016782 906 735457
SGTC_2234 tolnaftate 200 µM -0.887167422261672 0.176154191670181 no 2767 0.187494384522658 916 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2034 5197015 53.07 µM -0.890661798261609 0.175205809051946 no 2768 0.186555317488249 896 780676
SGTC_1849 st056239 19.2 µM -0.891782763873157 0.174902263399416 no 2769 0.186254690989917 871 5393181
SGTC_1636 st007707 68.9 µM -0.892548084651614 0.174695214439495 no 2770 0.186049615746291 922 403051
SGTC_2011 4012611 177 µM -0.892742958914771 0.174642518257968 no 2771 0.185997419634834 916 2049887
SGTC_1052 3253-3998 198 µM -0.895251636389016 0.173965045261122 no 2772 0.18532629368729 907 5450317
SGTC_121 0557-0495 61.343 µM -0.89600066104119 0.173763094140295 no 2773 0.185126205089088 917 3104427
SGTC_3341 9147222 25.867 µM -0.896711314532841 0.173571626526004 no 2774 0.184936490763391 896 1939759
SGTC_2317 5986382 200 µM -0.896732570928243 0.173565901596398 no 2775 0.184930818069286 936 877883
SGTC_3224 9130643 49.47 µM -0.897217486471254 0.173435333194724 no 2776 0.184801438031655 894 17644395
SGTC_2100 5377183 190 µM -0.898163394691676 0.173180817845573 no 2777 0.184549222768494 879 2844202
SGTC_297 0986-0032 24 µM -0.89976596009678 0.172750159049807 no 2778 0.184122406471416 901 2847425
SGTC_2492 derrusnin 100 µM -0.900590726355419 0.172528785193975 no 2779 0.183902983562205 913 1715307 Part of coumarin class of compounds.
SGTC_1389 3405-0187 19 µM -0.902257955617159 0.172081840277802 no 2780 0.183459927228244 888 799890
SGTC_514 4466-0038 2.65 nM -0.902776374174157 0.171943015229458 no 2781 0.183322296283502 878 5722064
SGTC_499 genistein 192 µM -0.904007547573026 0.171613611311299 no 2782 0.182995699636493 925 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_984 1492-0255 2.91 µM -0.90457918130959 0.171460806241437 no 2783 0.182844184325058 910 1585198
SGTC_634 1611-4317 11.2 µM -0.905124085386944 0.171315227330919 no 2784 0.182699826805154 919 2843522
SGTC_2154 5570129 200 µM -0.905180960234635 0.171300036958231 no 2785 0.182684763462985 930 673366
SGTC_443 clozapine 122 µM -0.907846500829912 0.17058907920357 no 2786 0.181979663201025 907 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1983 st071813 46.9 µM -0.908710959936124 0.17035891539153 no 2787 0.181751358684662 907 11838595
SGTC_2468 5987765 72.9 µM -0.910727933795893 0.169822666324595 no 2788 0.181219371032165 892 26772094
SGTC_1298 1079-1278 263 µM -0.911005047463691 0.169749075294132 no 2789 0.181146357093798 906 2840950
SGTC_1378 2093-0007 380 nM -0.911266908580083 0.169679553568447 no 2790 0.18107737883575 918 3618014
SGTC_284 0988-0104 32.6 µM -0.914621063642614 0.168790671711067 no 2791 0.180195298441958 921 4666532
SGTC_1686 st019653 115.5 µM -0.914691030454588 0.168772161779529 no 2792 0.180176927234269 929 97252
SGTC_1396 3511-0007 98.6 µM -0.916462392724344 0.168303977113171 no 2793 0.179712211794061 879 X1396
SGTC_2408 sulbentine 18.36 µM -0.917656682854397 0.167988788997137 no 2794 0.179399316186153 885 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1873 rapamycin 2 nM -0.918839899835103 0.167676898109872 no 2795 0.179089659642935 888 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_147 4466-0538 29.23 µM -0.920386971261434 0.167269659721234 no 2796 0.178685287323486 910 6742687 YHR072W ERG7
SGTC_2228 7354201 200 µM -0.921997685574448 0.166846346466472 no 2797 0.178264891447286 930 753451
SGTC_1439 4092-1168 46 µM -0.922760318905584 0.166646159407525 no 2798 0.178066062020567 924 2886240
SGTC_1055 3448-0672 86 µM -0.925089898967752 0.166035617820432 no 2799 0.177459573421847 900 748378
SGTC_1177 0983-0204 23.6 µM -0.925277961281989 0.165986393153907 no 2800 0.177410669764751 887 766818
SGTC_1548 st061468 90.8 µM -0.926128313248288 0.165763934180834 no 2801 0.177189650768195 909 390799
SGTC_2769 toremifene 3.73 µM -0.927688354881065 0.165356316058864 no 2802 0.176784625396948 921 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_426 0988-0037 14.6 µM -0.929419371295605 0.164904784222996 no 2803 0.176335896304044 920 5383008
SGTC_1120 ficusin 1.78878 µM -0.932089464976681 0.164209863450064 no 2804 0.175645146022798 930 6199 A DNA cross-linker.
SGTC_792 4534-1957 155 µM -0.93245636153259 0.164114523275219 no 2805 0.1755503644493 906 1717904
SGTC_1587 estradiol valerate 56.1 µM -0.934644859382233 0.163546575559843 no 2806 0.174985676235939 925 13791 A steroid.
SGTC_1962 st076595 64.5 µM -0.935099282818865 0.16342880613961 no 2807 0.174868568068677 903 279619
SGTC_2582 agaric acid 100 µM -0.935129052935141 0.163421092770963 no 2808 0.174860897833367 898 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1856 st057054 55.7 µM -0.935400470664257 0.163350779967413 no 2809 0.174790977223825 910 1266018
SGTC_680 0417-1641 114 µM -0.935557379587626 0.163310140497113 no 2810 0.174750563614687 919 2835990
SGTC_2867 9039098 71.43 µM -0.935969990321281 0.163203305511435 no 2811 0.174644319518194 899 6463460
SGTC_2514 salinomycin 42.74 µM -0.936371849559619 0.163099298015981 no 2812 0.174540883282333 918 23682228 A polyether potassium ionophore.
SGTC_1748 st037455 53.6035 µM -0.937687877466438 0.162758990904194 no 2813 0.174202417739699 910 580690
SGTC_650 1328-0195 38 µM -0.938127597301673 0.162645388274411 no 2814 0.174089420454921 921 2780821
SGTC_996 3970-0799 1.8 µM -0.940976771299749 0.161910547905426 no 2815 0.173358381550142 923 6615648 YGL040C HEM2
SGTC_486 niguldipine 82 µM -0.940982435729094 0.161909089130466 no 2816 0.17335693012444 900 1236 A calcium channel blocker.
SGTC_3298 9116858 71.43 µM -0.943544784796176 0.161250078863619 no 2817 0.172701159675988 960 2506942
SGTC_2988 9073640 71.4286 µM -0.94442431677792 0.161024276090275 no 2818 0.172476430059678 918 9102229
SGTC_1884 5633444 25 µM -0.944926192153979 0.160895521840317 no 2819 0.172348279267879 911 5724239
SGTC_2722 naftopidil 47.16 µM -0.947512118141366 0.160233177762839 no 2820 0.171688942105288 924 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2830 7992007 71.43 µM -0.949784491489029 0.159652618529096 no 2821 0.17111088380216 913 1952075
SGTC_1508 1080-0625 72.9 µM -0.950030625209386 0.159589817573707 no 2822 0.171048345809866 891 767111
SGTC_1928 4'-methoxychalcone 40.3 µM -0.951101433789924 0.159316789238806 no 2823 0.170776443485886 908 641818
SGTC_1632 st005650 90 µM -0.952982038002115 0.158838024826043 no 2824 0.170299585790808 926 2759605
SGTC_509 pifithrin 175 µM -0.956089215621173 0.158049067545186 no 2825 0.16951358140308 939 4817 A p53 inhibitor.
SGTC_2442 5158906 48.48 µM -0.956163957518083 0.158030121237105 no 2826 0.169494703100597 903 1893835
SGTC_3286 9117135 37.221 µM -0.956247503345079 0.158008944987466 no 2827 0.169473602698966 902 3438150
SGTC_337 1315-0038 354 µM -0.959929368401734 0.157077557741633 no 2828 0.168545382111439 903 1626437
SGTC_1064 honokiol 6.76 µM -0.960247328865759 0.156997294230385 no 2829 0.168465375946299 930 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2981 9013952 38.96 µM -0.96564063739966 0.155639959148904 no 2830 0.167112016681292 911 2996344
SGTC_33 0986-0033 35.816 µM -0.966192986948677 0.155501387456805 no 2831 0.166973810738919 871 2848082
SGTC_1720 st037298 9.481 µM -0.969701227446822 0.154623152071796 no 2832 0.166097719235467 948 597396
SGTC_1310 1188-0297 994 nM -0.970148776463736 0.154511351105165 no 2833 0.165986169530245 899 1588352
SGTC_1195 1502-0147 41.1 µM -0.970552146810362 0.154410632082331 no 2834 0.165885672661384 910 817940
SGTC_2815 7968870 71.43 µM -0.97166166656258 0.154133815969725 no 2835 0.165609446571455 938 2977326 YHR190W ERG9
SGTC_719 2810-4230 27.3 µM -0.973786100398311 0.153604703646391 no 2836 0.165081377973548 931 721079
SGTC_592 k241-0073 46.5 µM -0.975135696887386 0.153269198068226 no 2837 0.16474647683775 919 4230158
SGTC_639 0833-0042 114 µM -0.976752573622598 0.152867887229363 no 2838 0.164345830290556 943 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_170 4197-0004 226 µM -0.977621869182266 0.152652415245514 no 2839 0.164130688518727 931 218692
SGTC_3266 9136860 49.47 µM -0.978674543074965 0.152391759181682 no 2840 0.163870407138141 894 4871271 YPR165W RHO1
SGTC_1975 st070967 30.8 µM -0.980916307853026 0.151837653330395 no 2841 0.163317007395363 921 261391
SGTC_174 3553-0389 74.3 µM -0.984237439259823 0.151019219763048 no 2842 0.162499390745356 917 738071
SGTC_1685 st024049 53.0905 µM -0.985428558254393 0.150726406331705 no 2843 0.162206803784916 930 1941139
SGTC_2569 tetrandrine 100 µM -0.986345201151988 0.15050132507635 no 2844 0.161981872947027 922 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_73 0327-0325 16.231 µM -0.990192420515048 0.149559085022169 no 2845 0.161040038272755 866 53298
SGTC_1212 0520-0165 585 µM -0.990924647263198 0.149380198923677 no 2846 0.160861188071126 961 5403258
SGTC_220 paclitaxel 373.376 µM -0.991529202222088 0.149232611277167 no 2847 0.160713620136931 921 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1015 4130-4525 82 µM -0.991693919989698 0.149192416255059 no 2848 0.160673428930238 931 1363237
SGTC_3002 9075603 71.4286 µM -0.992145205133006 0.149082329072965 no 2849 0.16056334879047 903 20105405
SGTC_3154 9100113 49.47 µM -0.992413837488292 0.149016824257364 no 2850 0.160497845794711 927 25237525
SGTC_1135 dihydrocapsaicin 536.708 nM -0.992754140890172 0.148933870383368 no 2851 0.160414891685228 937 107982 A Capsaicinoid.
SGTC_999 SEC7.066 22.7 µM -0.994275289911127 0.148563445570502 no 2852 0.160044431126907 939 740511 YDR170C SEC7
SGTC_3051 9093778 49.47 µM -0.99478728335769 0.148438905421885 no 2853 0.159919866203653 962 17217378
SGTC_1288 0973-0013 65.5 µM -0.995068335333592 0.148370570459466 no 2854 0.159851514915207 929 4315430
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.996214813464787 0.148092033837256 no 2855 0.159572891690046 859 4000243
SGTC_59 0330-0160 1.33 µM -0.997539632935531 0.147770605307375 no 2856 0.159251323105419 931 4293482
SGTC_3169 9102970 49.47 µM -0.999299286476989 0.147344399897162 no 2857 0.158824865494041 951 17027839
SGTC_799 1310-0557 151 µM -0.999793486503842 0.147224848108912 no 2858 0.158705229311508 946 5354492
SGTC_1123 mangostin 811.285 nM -1.00193673899526 0.146707127127051 no 2859 0.158187073604291 876 5281650 An antioxidant.
SGTC_3104 9120930 49.47 µM -1.00196524788543 0.146700248803374 no 2860 0.158180188746035 932 17014836
SGTC_821 1114-0266 29.2 µM -1.00213780316641 0.146658621107679 no 2861 0.158138521077571 921 3123235
SGTC_330 1488-0319 80.1 µM -1.00368148873959 0.146286570945951 no 2862 0.157766081188216 914 6846614
SGTC_1929 genistein trimethyl ether 50.5 µM -1.00483984150272 0.146007808054419 no 2863 0.157486987934516 901 136420
SGTC_2353 9059630 146.67 µM -1.00512259092783 0.145939817339688 no 2864 0.157418911648732 946 4779114
SGTC_524 r073-0010 27.8 µM -1.00539466485242 0.14587441377375 no 2865 0.157353423916998 935 2772106
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.00559624554747 0.145825968707148 no 2866 0.15730491533724 936 6708784 An antioxidant flavonoid
SGTC_2987 9018338 71.43 µM -1.00741792395793 0.145388662587078 no 2867 0.156866990727613 908 5055682
SGTC_600 1495-0418 41.6 µM -1.00781050855102 0.145294535679665 no 2868 0.156772720039921 941 5377768
SGTC_1454 4239-0054 42.6 µM -1.0082547095613 0.145188082560775 no 2869 0.156666099755148 916 1340767
SGTC_2966 9084041 48.03 µM -1.008846028029 0.145046454084037 no 2870 0.156524241369112 939 17741380
SGTC_2065 5221596 34.26 µM -1.01089736568276 0.144555853042805 no 2871 0.156032777501882 918 788581
SGTC_2636 apigenin dimethyl ether 100 µM -1.01143066218064 0.144428492355478 no 2872 0.155905175930437 942 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_145 3737-0113 38.366 µM -1.01183413858705 0.144332185275788 no 2873 0.155808682066146 919 6849351
SGTC_543 3844-1095 191 µM -1.01222929240706 0.14423790670416 no 2874 0.155714216775034 942 4230703
SGTC_711 k292-0785 179 µM -1.01350327838268 0.143934232921847 no 2875 0.155409915501985 908 4146315
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.01557324083728 0.143441746311996 no 2876 0.154916326456058 933 6857784
SGTC_2512 diallyl trisulfide 49.23 µM -1.0160176434463 0.143336162317454 no 2877 0.154810492416191 959 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3046 9092212 49.47 µM -1.01633716671636 0.143260280389256 no 2878 0.154734427790916 960 25236637
SGTC_6 0844-0013 19.835 µM -1.02051358421063 0.14227093950091 no 2879 0.153742475045602 953 1584900
SGTC_963 1269-2853 151 µM -1.02365613634668 0.141529563300292 no 2880 0.152998860151536 943 3668223
SGTC_1944 st076371 56.9 µM -1.02518469247988 0.141169901445821 no 2881 0.152638024807383 921 24208455
SGTC_1034 k072-0165 12.7 µM -1.02636222644683 0.140893256345232 no 2882 0.152360438043521 962 5835461
SGTC_2882 9058044 58.44 µM -1.02696385817712 0.140752053451045 no 2883 0.152218741396939 930 18076804
SGTC_714 4296-0578 26.1 µM -1.02718146277277 0.140701005333695 no 2884 0.152167512591688 929 1589775
SGTC_2247 cerulenin 830 nM -1.02839300573489 0.140417017776715 no 2885 0.151882498628604 908 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2568 diosmetin 100 µM -1.02856047832396 0.140377792579998 no 2886 0.151843128831439 939 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1046 2001-0062 216 µM -1.02891316866359 0.140295210275817 no 2887 0.151760239845956 951 739778
SGTC_424 splitomicin 100 mM -1.03009877954011 0.140017841872242 no 2888 0.151481819050137 958 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1597 7-benzyloxygramine 47.5 µM -1.03122461256588 0.139754803356935 no 2889 0.151217750636482 929 260807
SGTC_647 0140-0236 81 µM -1.03135113090315 0.139725264748429 no 2890 0.151188094431258 950 990837
SGTC_843 0310-0051 143 µM -1.03522423483349 0.13882305338136 no 2891 0.150282101680126 935 2065037
SGTC_1583 clindamycin 39.6 µM -1.03907427189571 0.137930155340749 no 2892 0.149385097716825 951 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_595 3909-8003 73.7 µM -1.03953447923042 0.137823687080964 no 2893 0.149278115589033 959 699517
SGTC_266 formosanin C 406 nM -1.03988983012525 0.137741515570705 no 2894 0.149195543929035 903 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1322 1348-1070 12 µM -1.0402354913188 0.137661616793626 no 2895 0.149115253101735 915 6758089
SGTC_3122 9126309 49.47 µM -1.04408255383772 0.13677451224402 no 2896 0.148223598393114 965 17591206
SGTC_1486 3970-0793 4.53 µM -1.04611913257762 0.136306477458603 no 2897 0.147753016411633 943 2844330
SGTC_3228 9131799 49.47 µM -1.04767280858237 0.135950158287042 no 2898 0.147394689794842 950 17015818
SGTC_2621 lithochol-11-enic acid 100 µM -1.04849590045108 0.135761649507707 no 2899 0.147205095047878 965 6708711
SGTC_3331 9141060 1.957 µM -1.05023342730466 0.135364300133702 no 2900 0.146805402183447 928 4906567 YPR165W RHO1
SGTC_3306 9127676 59.7925 µM -1.05162763285702 0.13504604074727 no 2901 0.146485212359026 932 41905287
SGTC_2305 7443522 69.23 µM -1.05452345654742 0.134386643492569 no 2902 0.145821663609268 911 5415886
SGTC_1318 1280-3875 124 µM -1.05568381158195 0.134123044790888 no 2903 0.145556347777225 951 373245
SGTC_1600 coumarin 106 71.1 µM -1.05615132528716 0.134016939813197 no 2904 0.145449542303594 944 100336 A hepatotoxic, DNA x-linker.
SGTC_2340 7987427 183.45 µM -1.05800363140317 0.133597115105208 no 2905 0.145026893417881 934 2239331
SGTC_1966 st070145 16.1 µM -1.05805883395164 0.133584617354517 no 2906 0.145014310306577 949 3748532
SGTC_1826 st055655 41.6 µM -1.05853965578053 0.133475794216523 no 2907 0.144904740745833 954 676168
SGTC_2776 terbinafine 19.92 µM -1.05934534617292 0.133293581151212 no 2908 0.144721265198781 913 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1134 3477-0009 42.5 µM -1.06591846798651 0.131813412878783 no 2909 0.14323024990084 902 3973534
SGTC_1482 3346-2049 8.48 µM -1.06627568130503 0.131733299957626 no 2910 0.143149519669789 941 3826804
SGTC_2855 9016525 58.44 µM -1.06649362955568 0.131684436788275 no 2911 0.143100278453479 939 43811474
SGTC_2803 7707263 71.43 µM -1.06894540515622 0.131135619687357 no 2912 0.142547135322744 950 2199229
SGTC_2571 chrysanthemic acid 100 µM -1.07009869451824 0.130878009074475 no 2913 0.142287443346884 978 2743 An insecticide.
SGTC_1893 st059353 36.1 µM -1.07149013930583 0.130567667403882 no 2914 0.141974551047839 987 3112488
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.07179704693059 0.13049928464151 no 2915 0.141905599898188 932 17037758
SGTC_2216 7189485 200 µM -1.07234652987425 0.130376915016709 no 2916 0.141782207409185 939 731273
SGTC_3276 9139060 49.47 µM -1.07628154772379 0.12950290766902 no 2917 0.140900679258589 961 4870619
SGTC_98 0074-0023 107.663 µM -1.07668634004922 0.129413230003388 no 2918 0.14081020849122 965 3563821
SGTC_1327 1436-0082 2.18 µM -1.07816661113711 0.129085657287825 no 2919 0.140479704712092 957 15992205
SGTC_1957 st077035 62.4 µM -1.07829091965539 0.129058174949318 no 2920 0.140451974032749 957 705593
SGTC_51 1013-0126 23.419 µM -1.0815249743298 0.128344610123514 no 2921 0.139731828803935 924 1627850
SGTC_79 0052-0007 94.094 µM -1.08182093388238 0.128279446407275 no 2922 0.139666051419616 914 2801472
SGTC_2789 5281112 71.43 µM -1.08296686826104 0.128027353824677 no 2923 0.139411564654266 935 765948
SGTC_897 1000-0139 31.4 µM -1.08304862652335 0.128009381095349 no 2924 0.139393420009753 958 6151020
SGTC_283 0987-0079 11.7 µM -1.08310445222256 0.127997110068342 no 2925 0.139381031512584 950 411556
SGTC_2457 5731572 11.68 µM -1.08410364817256 0.12777761536943 no 2926 0.139159422746818 947 2865357
SGTC_2702 st077768 96.8 µM -1.08410931940626 0.127776370309072 no 2927 0.139158165625157 919 6484119
SGTC_3053 9095903 49.47 µM -1.08429404859752 0.1277358195473 no 2928 0.139117221606183 991 17174018
SGTC_2182 6325192 200 µM -1.08439372031406 0.127713943861915 no 2929 0.139095133426974 919 736248
SGTC_681 1642-0006 26.6 µM -1.0868069852021 0.127185081538103 no 2930 0.138561060027258 978 4446530
SGTC_2031 5180455 200 µM -1.08757749903367 0.127016546293153 no 2931 0.138390834261196 981 29949
SGTC_2180 6301957 200 µM -1.0878439744359 0.126958296056191 no 2932 0.138331996368324 960 845462
SGTC_3057 9095946 49.47 µM -1.0897970540162 0.126531929839567 no 2933 0.13790127598458 977 24540043
SGTC_1588 farnesol 29.9 µM -1.09107994206459 0.126252412844659 no 2934 0.137618853951364 954 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_927 2425-1185 123 µM -1.09335708403481 0.125757327229559 no 2935 0.13711852425084 968 730375
SGTC_468 gf-109203x 121 µM -1.09363749245789 0.12569645591454 no 2936 0.137056999441219 970 2396 A protein kinase C inhibitor.
SGTC_160 3453-0671 289.699 µM -1.09567620900234 0.125254507470119 no 2937 0.136610248869096 986 5322268
SGTC_640 3381-0960 37.1 µM -1.09983846511016 0.124355594287339 no 2938 0.135701254800326 951 1745025
SGTC_32 0928-0142 34.1 µM -1.10111655876854 0.124080474850791 no 2939 0.135422965555618 938 2244242
SGTC_2067 5224629 34.075 µM -1.10129379107252 0.124042357890184 no 2940 0.135384406292005 953 2835000
SGTC_3239 9133757 49.47 µM -1.1017306027732 0.12394844874576 no 2941 0.135289404180299 979 17036923
SGTC_753 1322-0200 289 µM -1.10423959709966 0.123410009525917 no 2942 0.134744608544937 961 5403907
SGTC_171 k064-0041 9.68 µM -1.10451825387362 0.123350310031224 no 2943 0.134684194845831 932 53325
SGTC_177 1327-0068 8.361 µM -1.10832980294094 0.122535753551125 no 2944 0.133859704442944 946 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2534 helenine 20.12 µM -1.10864573070381 0.122468407205852 no 2945 0.133791520950308 945 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1341 1486-1360 280 µM -1.10946421883615 0.122294050854349 no 2946 0.133614985995305 974 3976547
SGTC_1166 k206-0078 225 µM -1.11109610305208 0.12194694307079 no 2947 0.13326349255059 948 5404595
SGTC_323 4013-0906 34.3 µM -1.11358169663596 0.121419578857442 no 2948 0.132729341112552 931 2910086
SGTC_2190 6049624 200 µM -1.11370352036994 0.1213937730026 no 2949 0.132703199282021 936 2265554
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.11485528427466 0.121149986046208 no 2950 0.132456220590599 969 5377381
SGTC_1429 4049-0205 9.46 µM -1.11502745498435 0.121113573312169 no 2951 0.132419328365716 946 22774478
SGTC_627 1391-0720 175 µM -1.11513510386858 0.121090810342337 no 2952 0.132396265282821 970 997839
SGTC_1126 isoteolin 1.0172 µM -1.11516927284597 0.121083585746704 no 2953 0.132388945377427 942 133323
SGTC_2732 terfenadine 20 µM -1.11670070777958 0.120760094617319 no 2954 0.132061157567056 974 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_848 0368-0089 85.6 µM -1.11841079993349 0.120399584490717 no 2955 0.131695791927323 944 762535
SGTC_57 miconazole 162.5 nM -1.11989642790625 0.120087010279501 no 2956 0.13137895034034 918 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_970 1315-0089 19.5 µM -1.12216556530086 0.119610691277006 no 2957 0.130896025365457 944 6811083 YLR033W RSC58
SGTC_438 sphingosine 6.67 µM -1.12483951587031 0.119051109491127 no 2958 0.130328523045462 966 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_904 1141-0088 396 µM -1.12737253505975 0.118522727833987 no 2959 0.129792503098999 987 1378119
SGTC_2857 9024691 58.44 µM -1.12829836851649 0.118330015425665 no 2960 0.129596966134261 969 16478292
SGTC_1418 3966-3099 2.4 µM -1.12831955535025 0.118325607976391 no 2961 0.129592493843063 938 740335
SGTC_713 1488-1073 324 µM -1.129208598041 0.118140767033905 no 2962 0.129404923758323 968 3312542
SGTC_967 1306-0166 352 µM -1.13027192364149 0.117919959206 no 2963 0.1291808306593 946 4437607
SGTC_2563 tomatine 8.54 µM -1.13174073926116 0.117615428678597 no 2964 0.128871724280652 970 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3055 9094636 49.47 µM -1.13272196875173 0.117412300137207 no 2965 0.128665514515909 970 25236176
SGTC_672 1441-0018 53.7 µM -1.13284400255358 0.117387054774061 no 2966 0.128639884583803 941 251141
SGTC_230 MPP+ 141.667 µM -1.13426635583312 0.117093093336007 no 2967 0.128341418639561 972 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3220 9131269 49.47 µM -1.14212082099669 0.115479182721247 no 2968 0.126701900986294 963 17722206
SGTC_2649 anisomycin 9.56 µM -1.14389222024321 0.11511739605594 no 2969 0.126334168916499 966 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2315 7733312 200 µM -1.14631144684657 0.114624601545689 no 2970 0.125833154126907 947 726316
SGTC_2272 7805186 180 µM -1.14796402873653 0.114288836129648 no 2971 0.125491706900051 972 2956062 YPR165W RHO1
SGTC_2806 7952793 58.44 µM -1.14880435912956 0.114118369804743 no 2972 0.125318330754274 952 2972490
SGTC_3258 9138477 49.47 µM -1.15032615325355 0.113810125374589 no 2973 0.125004781449031 993 4970355
SGTC_2291 7917025 104.35 µM -1.1504199517446 0.113791145613058 no 2974 0.12498547322432 957 2964612
SGTC_1184 1269-1718 139 µM -1.1548784584946 0.112891584673613 no 2975 0.124070100964872 950 5403821
SGTC_1114 scopoletin 1.73284 µM -1.15566534553446 0.112733348611321 no 2976 0.123909034098607 978 5280460 A coumarin with genotoxic properties.
SGTC_1554 st069299 38.7 µM -1.15644086882815 0.112577552718174 no 2977 0.123750436510598 964 24207999
SGTC_741 4582-0002 126 µM -1.16184860943747 0.111495458437727 no 2978 0.122648482479611 951 2912688
SGTC_2585 alliin 100 µM -1.16270110782272 0.111325554133602 no 2979 0.122475395997023 983 87310 A garlic compound which reacts with lipids.
SGTC_1016 4226-1401 38 µM -1.16309535273937 0.111247043190827 no 2980 0.122395408714457 960 2901613
SGTC_521 r062-0005 13.8 µM -1.16424353316029 0.111018617455592 no 2981 0.122162666392875 964 2832033
SGTC_1906 st060206 94.7 µM -1.16600992069056 0.110667858236249 no 2982 0.121805217224725 958 5133468
SGTC_2400 5203494 178.7 µM -1.16780476518963 0.110312262432612 no 2983 0.121442762775545 957 6777674
SGTC_396 dithiazanine 1.25 µM -1.17004179039346 0.109870209493268 no 2984 0.120992075833469 956 10578 An antihelmenthic.
SGTC_226 1,3-diallylurea 8.28947 mM -1.17041006565435 0.109797557588346 no 2985 0.120917993450475 964 74537 YKL182W FAS1
SGTC_3322 9139058 2.11 µM -1.17252041008645 0.109381901986605 no 2986 0.120494091328058 967 4908926 YPR165W RHO1
SGTC_224 benfluorex 43.875 µM -1.17294569831947 0.109298273800002 no 2987 0.120408791094223 981 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3070 9117005 49.47 µM -1.1739394242529 0.10910304775914 no 2988 0.120209644898331 1004 8779016
SGTC_452 diindolylmethane 8 µM -1.17426730607464 0.109038687561013 no 2989 0.12014398716722 970 3071 Inhibits expression of several cancer promoting factors.
SGTC_1059 3448-6867 171 µM -1.1771621321967 0.108471643439366 no 2990 0.11956539990549 965 3934407
SGTC_2903 5923464 63.88 µM -1.17838639850806 0.108232471235014 no 2991 0.119321298827161 979 2876576
SGTC_95 0471-0001 561.058 µM -1.18064338171932 0.107792543192645 no 2992 0.118872211123343 961 4015405
SGTC_1198 1612-1005 86.7 µM -1.18079787400341 0.107762476940267 no 2993 0.11884151442753 981 6998509
SGTC_195 4234-0266 16.654 µM -1.18370259639009 0.107198303536796 no 2994 0.118265405416495 973 2303354
SGTC_379 3970-0972 5.9 µM -1.18469003004379 0.107007003888748 no 2995 0.11807001292014 978 2898042 YBL034C STU1
SGTC_928 2764-0428 58.7 µM -1.18598082903819 0.106757303515866 no 2996 0.117814935237703 982 662578
SGTC_3309 9129340 25.759 µM -1.18687576495449 0.106584428413429 no 2997 0.117638313999555 966 17158987
SGTC_1973 st070275 50.2 µM -1.18781834912493 0.106402567677529 no 2998 0.117452491821237 977 17118334
SGTC_2081 5214970 32.255 µM -1.18825809715643 0.106317800063701 no 2999 0.117365870501857 976 2063512
SGTC_1857 st056007 79.3 µM -1.19207968072337 0.105583189058849 no 3000 0.116615001736349 959 619834
SGTC_1449 4112-4002 201 µM -1.19251377075485 0.105499978006449 no 3001 0.116529927207068 969 2059539
SGTC_3097 9117246 49.47 µM -1.194901194897 0.105043178501346 no 3002 0.116062817994897 963 16423892
SGTC_2085 5307070 144.047 µM -1.19635317413896 0.104766064055007 no 3003 0.115779383164541 985 2840351
SGTC_1116 jasmonic acid 1.58368 µM -1.19647473101846 0.104742888610384 no 3004 0.115755676870331 970 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2245 6637752 200 µM -1.19702241906546 0.104638515114191 no 3005 0.115648908282286 986 681890
SGTC_1344 1488-0097 29.1 µM -1.19717626621596 0.104609209855822 no 3006 0.115618929267509 989 747966
SGTC_975 1335-0046 28.5 µM -1.19740324754686 0.104565984639965 no 3007 0.11557470923732 981 16486740
SGTC_252 miconazole 1.30953 nM -1.19961770294624 0.104144953313837 no 3008 0.115143924007501 953 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1972 st070201 17.4 µM -1.2000114712776 0.104070215566629 no 3009 0.115067442674897 981 2829099
SGTC_2529 gangaleoidin 93.61 µM -1.20015830425517 0.104042356430715 no 3010 0.115038932662662 988 4565183
SGTC_1232 0279-0259 161 µM -1.20102487086981 0.103878049831313 no 3011 0.11487077695448 967 1560000
SGTC_3235 9132602 49.47 µM -1.20211446042068 0.103671723838442 no 3012 0.114659592276129 971 4912240
SGTC_2166 5933061 31.504 µM -1.20267398149522 0.103565887873863 no 3013 0.114551253109815 973 2877375
SGTC_2875 9039966 71.43 µM -1.20502142703649 0.103122712360006 no 3014 0.114097515111781 980 6463691
SGTC_2560 caryophyllene 100 µM -1.20691008329748 0.102767152990769 no 3015 0.113733387016742 984 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1281 0884-0031 11.8 µM -1.20980091827465 0.102224649728848 no 3016 0.113177646895199 987 1548255
SGTC_885 0865-0106 16.8 µM -1.21077964701859 0.102041451251608 no 3017 0.112989933795697 969 2793380
SGTC_2292 7671323 168.05 µM -1.21116849659273 0.101968732724968 no 3018 0.112915416970727 984 937504
SGTC_2114 5491910 81.25 µM -1.2138275672855 0.10147247200564 no 3019 0.112406788493059 974 2849228
SGTC_747 3448-8087 38.7 µM -1.21383088682785 0.101471853582862 no 3020 0.112406154553906 998 5168703
SGTC_3120 9124077 49.47 µM -1.21418808489825 0.101405324478632 no 3021 0.112337954701521 1012 18774327 YGL155W CDC43
SGTC_1352 1496-0991 99 µM -1.21549055551859 0.101163004978511 no 3022 0.112089524374893 993 3000039
SGTC_898 1000-0849 28.3 µM -1.21865401929297 0.100576212783202 no 3023 0.111487768386352 978 6751807
SGTC_200 k038-0079 37.545 µM -1.21937291808065 0.100443210885972 no 3024 0.111351342004988 1004 3436683
SGTC_2251 lansoprazole 556 µM -1.22097054858142 0.100148096354989 no 3025 0.111048585501702 985 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_60 0986-0278 202 µM -1.2235302004753 0.0996765974509524 no 3026 0.110564752329445 972 3110598
SGTC_2342 7990637 118.86 µM -1.22581861489637 0.0992564366837244 no 3027 0.1101334702565 1004 2033102 YER133W GLC7
SGTC_2254 7938975 95.19 µM -1.22588688975028 0.0992439211102246 no 3028 0.110120621519618 987 2969277
SGTC_551 k048-0028 34.9 µM -1.22611147002235 0.0992027610792093 no 3029 0.110078365041262 984 6836383
SGTC_738 1315-0003 72.4 µM -1.22887462860028 0.0986973634612632 no 3030 0.109559407665789 990 6251474
SGTC_1942 st076330 65.2 µM -1.23061083497926 0.0983807668755342 no 3031 0.109234225443882 988 24208414
SGTC_584 0986-0246 15.4 µM -1.2335587934708 0.0978449122461763 no 3032 0.10868367789157 1003 53315 YDR232W HEM1
SGTC_392 N-ethylmaleimide 8.33 µM -1.2338893429383 0.0977849614446964 no 3033 0.10862207059873 956 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_282 k297-0036 65.7 µM -1.23394197826016 0.0977754176143401 no 3034 0.108612262828515 995 5061378
SGTC_2904 7225135 42.03 µM -1.23467395156176 0.0976427670709288 no 3035 0.108475937051238 1006 4446116
SGTC_2567 aureobasidin a 60 nM -1.23500590733197 0.0975826524954964 no 3036 0.108414152807189 966 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1276 0871-0068 94.2 µM -1.23944366111639 0.0967816153390235 no 3037 0.107590620366968 976 3414906
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.24308404845953 0.0961281205903387 no 3038 0.106918431633344 998 140250 A respiratory chain inhibitor.
SGTC_3077 9117319 49.47 µM -1.24652881761655 0.0955127344716538 no 3039 0.106285158142599 1004 17154678
SGTC_1614 st002383 48.6 µM -1.24734979091334 0.0953665015896561 no 3040 0.106134634035442 963 1947235
SGTC_3089 9117425 49.47 µM -1.24908739776086 0.0950575403995464 no 3041 0.105816554717904 1000 9401657
SGTC_2656 pseudo-anisatin 100 µM -1.24992674669744 0.0949085614138115 no 3042 0.10566315392814 1019 6708809 A neurotoxin.
SGTC_2016 5121758 140 µM -1.25130478424224 0.094664341868449 no 3043 0.105411650325998 973 2795203
SGTC_2141 5621638 7.665 µM -1.25685401958943 0.0936855789350314 no 3044 0.104403250472083 987 2856238
SGTC_607 4491-0986 66.8 µM -1.26261720868291 0.0926770097112301 no 3045 0.103363390196357 939 698981 YDR232W HEM1
SGTC_2253 7938677 135.83 µM -1.2629159524878 0.0926249487519981 no 3046 0.103309693143588 1003 2301972
SGTC_117 lucigenin 22.078 µM -1.26450660389349 0.0923481160995494 no 3047 0.103024125956463 1013 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1062 mesoridazine 14.2 µM -1.26803753876825 0.0917357907852317 no 3048 0.102392272652727 964 4078 A neuroleptic.
SGTC_1784 st039334 36.3 µM -1.26853106241055 0.0916504453776846 no 3049 0.102304182592351 977 3496984
SGTC_1774 st048371 48.465 µM -1.27075119088435 0.0912672444430397 no 3050 0.101908588905376 992 4242727
SGTC_1651 st011928 86.1 µM -1.27163645879473 0.0911147762375255 no 3051 0.101751158271794 998 720198
SGTC_305 1682-2595 20.8 µM -1.27290993097075 0.0908957796967279 no 3052 0.101525002410541 975 226033
SGTC_2784 7567673 72.73 µM -1.28193363096019 0.0893551680825217 no 3053 0.0999329645713424 962 3471247
SGTC_39 0986-0283 58.349 µM -1.2821092278799 0.089325382391555 no 3054 0.0999021661592142 973 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_893 0958-0369 48.9 µM -1.28273229884471 0.0892197533574929 no 3055 0.099792940021548 998 6819948
SGTC_1231 0242-0792 125 µM -1.28496470042576 0.0888420580146104 no 3056 0.0994023098171971 992 3707635
SGTC_37 0566-0070 1.56 µM -1.28547278968553 0.0887562620100563 no 3057 0.0993135596774613 979 1626686
SGTC_948 3448-0295 75.3 µM -1.28558255683611 0.0887377348250933 no 3058 0.0992943937886015 966 678569
SGTC_3037 9091026 49.47 µM -1.2861558493309 0.0886410177385026 no 3059 0.0991943380195952 984 25236398 YIL048W NEO1
SGTC_278 4092-0821 23.9 µM -1.28687456486055 0.08851987805906 no 3060 0.0990690059935637 1009 877900
SGTC_737 1950-0117 57.9 µM -1.28928733931548 0.088114106325804 no 3061 0.0986491054225547 990 5393513
SGTC_1981 st071826 47 µM -1.29019255773479 0.0879622281997839 no 3062 0.098491904745976 976 11838600
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.2916568329944 0.0877169645810671 no 3063 0.098238006409325 994 688803
SGTC_755 1995-0008 37.3 µM -1.29473929737936 0.0872023250566972 no 3064 0.0977050893526258 986 689533
SGTC_2907 7721985 69.9 µM -1.2960952755288 0.0869766501563558 no 3065 0.097471331233893 991 3267881
SGTC_701 4424-0219 185 µM -1.2963130728778 0.0869404429316306 no 3066 0.0974338232476715 991 2911779
SGTC_152 4469-0003 551.229 µM -1.29880406842932 0.0865271335611897 no 3067 0.0970055890439594 984 697280
SGTC_1125 tnp00248 1.32998 µM -1.29930839257186 0.086443634502358 no 3068 0.096919057663296 983 24207736
SGTC_2380 9035439 200 µM -1.30450138073478 0.0855873521243097 no 3069 0.0960313445278504 982 6462575
SGTC_1452 4194-0072 190 µM -1.30558508865729 0.085409461072416 no 3070 0.0958468469600925 995 1343545
SGTC_2448 5185112 27.17 µM -1.30621736862601 0.0853058000910212 no 3071 0.0957393239627344 960 5718189
SGTC_235 0330-0087 5 mM -1.30658626621981 0.0852453636538885 no 3072 0.0956766317213279 1003 46494818 YHR062C RPP1
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.30800812349227 0.085012721089025 no 3073 0.0954352769857734 989 1241132 A phosphatase inhibitor.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.3090504039831 0.0848424869298555 no 3074 0.0952586388069108 1009 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2093 5331342 194.4 µM -1.31044347823854 0.0846153573912626 no 3075 0.0950229266755157 993 33839
SGTC_2211 7117706 200 µM -1.31044459355054 0.0846151757315162 no 3076 0.0950227381338275 980 822771
SGTC_1572 epiandrosterone 68.9 µM -1.31234290932688 0.0843064057069486 no 3077 0.0947022301688586 991 441302 A steroid.
SGTC_3212 9128307 49.47 µM -1.31352175309051 0.0841150872469428 no 3078 0.0945035978977739 996 27243542
SGTC_2493 resveratrol 26.09 µM -1.31657352662949 0.0836213190580666 no 3079 0.0939908087251958 966 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2872 9044037 25.97 µM -1.31687549624764 0.0835725798959209 no 3080 0.0939401806554648 1003 6465195
SGTC_2683 piperine 63.03 µM -1.31970115385753 0.083117540882305 no 3081 0.0934674073249119 997 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1915 st067105 30.6 µM -1.32029426401913 0.0830222644785803 no 3082 0.0933683949685976 978 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_25 0118-0223 35.662 µM -1.32288608266751 0.0826068818860682 no 3083 0.0929366321218051 998 5333628
SGTC_1312 1218-2183 165 µM -1.3239083269591 0.0824434808637399 no 3084 0.0927667461948803 995 6744073
SGTC_359 0081-0058 15.9 µM -1.32582806263107 0.0821372777862023 no 3085 0.0924483277122727 995 3494159
SGTC_1363 1636-0063 10.4 µM -1.32633757618639 0.0820561530239434 no 3086 0.0923639527999129 988 6072185
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.3264864950806 0.0820324535574116 no 3087 0.0923393027519334 990 688788
SGTC_2909 7941780 10.49 µM -1.3280882434954 0.0817778717450179 no 3088 0.0920744784118095 965 1243215
SGTC_1172 0370-0043 85 µM -1.3337822194927 0.0808776918454549 no 3089 0.0911376199033122 1006 376585
SGTC_752 1896-0090 130 µM -1.33404430969981 0.080836437930257 no 3090 0.0910946677012817 1002 772567
SGTC_222 nsc-310342 10.666 µM -1.33432422218794 0.0807923962722117 no 3091 0.0910488113068328 1001 432556
SGTC_2033 5192550 145 µM -1.3361829466543 0.0805004025386625 no 3092 0.0907447418131798 980 182073
SGTC_3141 9094609 49.47 µM -1.33619756088387 0.0804981098994948 no 3093 0.0907423540549367 1003 25236309 YDL196W YDL196W
SGTC_2189 6047310 154.431 µM -1.3371452115437 0.0803495504120291 no 3094 0.090587620872352 995 711535
SGTC_1847 st056231 15 µM -1.34176630625621 0.0796280864356538 no 3095 0.0898358901219643 984 5393180
SGTC_1423 4048-0112 5.59 µM -1.34484576066227 0.0791500378790618 no 3096 0.0893375245169505 990 X1423
SGTC_1496 4469-0713 57.4 µM -1.34700083598497 0.0788167829114036 no 3097 0.0889899817194123 1025 746691
SGTC_3092 9117248 49.47 µM -1.34988444976472 0.0783725330647971 no 3098 0.0885265252141 1032 17141857
SGTC_2782 7736369 71.43 µM -1.35265424343625 0.0779476085477977 no 3099 0.088083057315632 1003 2950836 YOL077C BRX1
SGTC_274 sirtinol 40.1 µM -1.35781922550166 0.0771599018764034 no 3100 0.0872605264547422 998 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1093 fluphenazine 7.97 µM -1.35960627124035 0.0768887742137758 no 3101 0.0869772762782075 1019 6602611 An atypical antipsychotic.
SGTC_1623 st003709 20.3 µM -1.36139815817737 0.0766176398511079 no 3102 0.0866939489287894 991 16192618
SGTC_353 1988-1175 58.3 µM -1.36585803154793 0.0759459643659679 no 3103 0.0859917638312935 982 2788357
SGTC_3172 9105863 49.47 µM -1.36720428505179 0.0757440965274964 no 3104 0.0857806413046044 1036 2348785
SGTC_153 4077-0274 519.67 µM -1.36751898056707 0.0756969675966031 no 3105 0.0857313460359406 978 3121976
SGTC_2889 9059656 51.95 µM -1.37217353003456 0.0750025064213494 no 3106 0.0850047117708503 1016 3949838
SGTC_447 ml7 120 µM -1.37227535565366 0.0749873684847708 no 3107 0.0849888672581262 1030 4216 Selective myosin light chain kinase inhibitor.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.37316948973652 0.0748545418284747 no 3108 0.0848498311296955 1032 279621
SGTC_3035 9091303 49.47 µM -1.37388552725637 0.0747483015080717 no 3109 0.0847386116943266 1024 25237002
SGTC_2929 9013348 24.6 µM -1.37430054270588 0.0746867772936743 no 3110 0.0846741989577777 1005 2995952
SGTC_1868 st057644 42.7 µM -1.37459229433917 0.0746435495350497 no 3111 0.0846289394456574 1018 688665
SGTC_599 1935-0052 86.5 µM -1.37469208448266 0.0746287683824595 no 3112 0.08461346313812 1006 9557311
SGTC_2497 7-hydroxyflavone 100 µM -1.37730889635021 0.0742419568770115 no 3113 0.0842083829437748 1001 5281894
SGTC_1250 0485-0349 40.2 µM -1.37943149041592 0.0739293258157728 no 3114 0.0838808778277881 1010 6842794 YDL195W SEC31
SGTC_2756 carbadox 75.1 µM -1.3909795994244 0.0722460344658293 no 3115 0.0821158065516654 982 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1628 st004252 77.7 µM -1.39203221959082 0.0720940737042165 no 3116 0.0819563207511412 994 692968
SGTC_2705 st078069 42.8 µM -1.39366801679784 0.0718584094169782 no 3117 0.081708939320621 1010 1530061
SGTC_2428 5615643 7.78 µM -1.39669065960175 0.0714245015405335 no 3118 0.0812533070944371 996 2253075
SGTC_1377 2944-0135 198 µM -1.39714708080306 0.0713591562601445 no 3119 0.081184673208261 975 1894137
SGTC_411 enrofloxacin 100 µM -1.40237669343521 0.0706137102761572 no 3120 0.0804013946601226 1002 71188 A bacterial gyrase inhibitor.
SGTC_2191 5911152 200 µM -1.40251571929487 0.0705939750608042 no 3121 0.0803806498989074 1008 2875902
SGTC_2537 larixol 68.93 µM -1.40567013361433 0.0701473331543118 no 3122 0.0799110497814775 1002 6708759
SGTC_71 0417-1750 47.813 µM -1.41182765702269 0.0692817397534724 no 3123 0.0790003564348447 967 6811472
SGTC_3109 9122853 49.47 µM -1.41337877695156 0.0690649940311329 no 3124 0.0787721911896587 1034 1234709
SGTC_2030 5175110 200 µM -1.41431192748391 0.0689348522320348 no 3125 0.0786351682036068 1025 2831986
SGTC_2880 9042983 58.44 µM -1.41579613429739 0.0687282469385187 no 3126 0.0784176008705621 1025 6464714
SGTC_94 0334-0113 514.748 µM -1.41875294954672 0.068318074408237 no 3127 0.0779855271127035 1001 6795178
SGTC_916 4466-0038 42 nM -1.42820816513787 0.0670191090374474 no 3128 0.0766159755704004 1024 5722064 YGL116W CDC20
SGTC_2655 perillic acid 100 µM -1.43054744649432 0.0667007031560198 no 3129 0.0762799792202307 1026 5702197 An apoptosis inducer.
SGTC_2023 5144124 124 µM -1.4309479195621 0.0666463112419281 no 3130 0.0762225709412922 996 2830192
SGTC_1683 st010134 710 nM -1.43397137309863 0.0662367755819951 no 3131 0.0757902161356839 1024 3818134
SGTC_2715 st079500 56.4 µM -1.43424904377522 0.0661992622084113 no 3132 0.0757506029822659 1011 28246688
SGTC_1346 1488-2224 62.4 µM -1.43469024800835 0.0661396892631638 no 3133 0.0756876921870031 993 3722427
SGTC_3174 9107204 49.47 µM -1.43755970510272 0.0657532578879299 no 3134 0.0752795104609274 1025 3938802
SGTC_350 k064-0020 19.8 µM -1.44292220382996 0.0650357814628595 no 3135 0.0745211937851825 962 2790705
SGTC_1289 0976-0073 69.1 µM -1.44440071105578 0.0648390368103692 no 3136 0.0743131454173695 1019 3391136
SGTC_221 trifluoperazine 10.304 µM -1.44469298285356 0.0648001990230423 no 3137 0.0742720709023043 1007 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_917 harmaline 728.087 nM -1.44649215683492 0.0645615181245073 no 3138 0.0740196051477235 988 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1668 st014914 51.6 µM -1.44726478863321 0.0644592295670315 no 3139 0.0739113884753028 1026 2839556
SGTC_2956 9076196 2.52 µM -1.44915312285556 0.0642097633319022 no 3140 0.0736474126849664 1033 16423868
SGTC_2281 7943571 200 µM -1.45084960062299 0.0639862836227299 no 3141 0.0734108722646735 1019 1244024
SGTC_720 r052-1644 49.9 µM -1.45365930078822 0.0636174882878303 no 3142 0.0730203935770405 1022 1422863 YOR257W CDC31
SGTC_1546 5-methoxyflavanone 78.7 µM -1.45495825052855 0.0634475509078651 no 3143 0.0728404099541909 1020 147795
SGTC_2240 6690706 185.951 µM -1.4569967684124 0.063181570816279 no 3144 0.0725586361315024 1015 805876
SGTC_1021 4476-0760 85.3 µM -1.4623800994019 0.0624833425072423 no 3145 0.0718185398597736 1030 746768
SGTC_1090 efavirenz 20.7 µM -1.46609233612178 0.0620053733213767 no 3146 0.0713115666627523 1000 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.46708674431144 0.0618778239695515 no 3147 0.0711762298134827 1024 66535 A nucleotide analog.
SGTC_1545 lovastatin 49.4 µM -1.47170796362469 0.0612877612419213 no 3148 0.0705498780873443 1024 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_188 3229-0966 278.469 µM -1.47515347270258 0.0608506875657441 no 3149 0.0700856435230837 998 5722370
SGTC_1571 st070080 73.4 µM -1.47756704310961 0.0605459729141443 no 3150 0.0697618505387308 1000 4315245
SGTC_1030 k029-0042 36.7 µM -1.490702348262 0.0589085117624718 no 3151 0.0680198296493203 1011 6080581
SGTC_231 b-estradiol 524 µM -1.49199557666182 0.0587491937578551 no 3152 0.0678501524686285 1024 450 A steroid.
SGTC_1259 0671-0132 43 µM -1.50053103555668 0.0577061430324998 no 3153 0.0667384502091535 1012 X1259
SGTC_767 0929-0023 86 µM -1.5043604398008 0.0572429393950954 no 3154 0.0662442922813784 1019 1204563
SGTC_1563 conessine 56.1 µM -1.50532727068699 0.0571264556854361 no 3155 0.0661199786575577 1039 441082 An anti-amoebic, histamine inhibitor.
SGTC_1711 st032263 62.8 µM -1.50611443570446 0.0570317559674166 no 3156 0.0660188997210469 1026 3958979
SGTC_1753 st043925 64 µM -1.50706215247663 0.0569179051297634 no 3157 0.0658973634112186 1033 670181
SGTC_1718 roemerine 11.9335 µM -1.52011666658296 0.0553677899263254 no 3158 0.0642408282550478 963 235224 An aporphine alkaloid with mutagenic activity.
SGTC_576 1073-0113 22.7 µM -1.52279585575032 0.055053819695292 no 3159 0.063904893566767 1034 5439563
SGTC_847 0342-0274 5.54 µM -1.52502857231021 0.0547932469797406 no 3160 0.0636259856068087 1023 18097
SGTC_1617 st002906 78 µM -1.52514945705474 0.0547791668026959 no 3161 0.0636109119176617 1033 5150859
SGTC_1777 st045864 34.765 µM -1.52829413834728 0.0544138907368582 no 3162 0.0632197623090353 1049 4691462
SGTC_2597 laccaic acid a 100 µM -1.5310214046114 0.0540986627106562 no 3163 0.0628820513255881 1031 5491415 A textile dye.
SGTC_3303 9125618 40.5795 µM -1.53302650472332 0.053867828738287 no 3164 0.0626346622596128 1008 22695467
SGTC_457 grayanotoxin iii 135 µM -1.53721735023766 0.0533878830897588 no 3165 0.0621200464716768 1000 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2379 9035213 200 µM -1.53722527388509 0.0533869788750238 no 3166 0.0621190766194667 1019 646551
SGTC_920 mycophenolic acid 780.421 nM -1.53822683866579 0.0532727820251267 no 3167 0.0619965804636451 1029 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1268 0828-0275 2.46 µM -1.53897077419753 0.0531880850476094 no 3168 0.0619057156593319 1026 745337
SGTC_2751 anetholtrithion 17.25 µM -1.54055536178101 0.0530080358004219 no 3169 0.0617125195255293 1031 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_888 0916-0002 6.97 µM -1.54066096120553 0.0529960542335113 no 3170 0.0616996613783073 1034 2802138 YIL048W NEO1
SGTC_1905 st060207 84.5 µM -1.54606350283395 0.0523859293413762 no 3171 0.0610446160402816 1020 1948547
SGTC_3161 9100388 49.47 µM -1.54737153124618 0.0522390516153021 no 3172 0.0608868409908205 1051 25236368
SGTC_757 1066-0008 322 µM -1.54781181263648 0.0521896863144765 no 3173 0.0608338058073455 1010 6842497
SGTC_1362 1611-0397 101 µM -1.551101314601 0.0518220317997143 no 3174 0.0604387031074508 1031 27816
SGTC_2892 9047358 58.44 µM -1.55327751714956 0.0515799397273425 no 3175 0.0601784245479645 1043 6466771
SGTC_2961 9083290 32.55 µM -1.5542108282104 0.051476389271731 no 3176 0.0600670677341197 1031 17741490
SGTC_2250 alverine citrate 130 µM -1.55453770523353 0.0514401615233589 no 3177 0.0600281049936581 994 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_110 0850-0284 111.64 µM -1.55568960717109 0.0513126579548296 no 3178 0.0598909595469678 1002 3906265
SGTC_1807 st050092 58.9 µM -1.55679480978504 0.0511905599678712 no 3179 0.0597596049397207 1036 5008496
SGTC_1624 st003710 6.25 µM -1.5569624772595 0.0511720570050143 no 3180 0.0597396971994908 1022 24207033
SGTC_2224 6650123 117.647 µM -1.55712630076402 0.0511539833843034 no 3181 0.0597202508860835 1057 2908370
SGTC_2394 5221648 200 µM -1.55803319715725 0.0510540230617206 no 3182 0.0596126894275065 1038 788586
SGTC_712 r015-0009 80.6 µM -1.558733569657 0.0509769327429921 no 3183 0.0595297264505798 1040 6813872 YLR060W FRS1
SGTC_237 nikkomycin 200 µM -1.5592381475819 0.0509214510668047 no 3184 0.0594700125212187 1044 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_333 3486-0131 40.1 µM -1.55977722962403 0.0508622285596463 no 3185 0.0594062671138743 1007 6744690
SGTC_1613 st002381 52.1 µM -1.56110839100746 0.0507162246301471 no 3186 0.0592490892977213 1017 551167
SGTC_1082 camptothecin 424.86 nM -1.56314687898975 0.0504932871120323 no 3187 0.0590090256783269 980 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1943 st076331 65.2 µM -1.56332689912697 0.0504736369392001 no 3188 0.0589878622333217 1045 24208415
SGTC_2132 5317594 122.667 µM -1.56866133319128 0.0498941148535996 no 3189 0.0583634364497249 1034 794577
SGTC_2279 7948423 32.93 µM -1.56960739664199 0.0497918926786445 no 3190 0.058253238330111 1017 1247112
SGTC_2652 actinonin 100 µM -1.57110885992588 0.0496300025924804 no 3191 0.0580786824861507 1041 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2691 st077356 60.2 µM -1.57440701744319 0.0492758648051972 no 3192 0.0576966912633907 1030 2839272
SGTC_965 1291-5240 308 µM -1.5768533262642 0.0490144994118104 no 3193 0.0574146390575047 1035 2834598
SGTC_1222 0366-0074 1.18 µM -1.57935857694481 0.0487479856698211 no 3194 0.0571269164809821 1040 286520
SGTC_2674 ligustilide 100 µM -1.57988564522628 0.0486920628009966 no 3195 0.0570665285912512 1033 5319022 A signalling regulator.
SGTC_2165 5727197 32.143 µM -1.58277000822597 0.0483869344517055 no 3196 0.0567369474773252 1032 1361712
SGTC_1434 4073-0095 163 µM -1.58339285245656 0.0483212467694855 no 3197 0.0566659755407098 1027 24133745
SGTC_2592 piperlongumine 83.33 µM -1.58850532209916 0.0477847569250446 no 3198 0.0560860592738103 1035 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1361 1608-0041 5.61 µM -1.5948693822892 0.0471236035465754 no 3199 0.0553707238275127 1034 X1361
SGTC_2688 kanamycin b 96.69 µM -1.59506233458618 0.0471036731283232 no 3200 0.0553491485863052 997 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1935 st074532 41.6 µM -1.60344183467968 0.0462446381107997 no 3201 0.0544185705423601 1014 2829742
SGTC_172 1112-0046 2.638 µM -1.60367404115404 0.0462210135126861 no 3202 0.0543929603761104 1047 2802135 YIL048W NEO1
SGTC_2758 dehydroepiandrosterone 69.35 µM -1.60836164962777 0.0457461673625131 no 3203 0.0538779978856457 1034 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2622 2-methoxyxanthone 59.94 µM -1.6115503356936 0.0454254058776976 no 3204 0.0535299127086101 1043 71034 A hepatoprotective.
SGTC_1812 st052057 4.327 µM -1.61593526567775 0.0449872665815302 no 3205 0.0530541549681117 1034 3645418
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.6288406589835 0.0437174777019529 no 3206 0.0516733774595206 1043 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1934 st074720 32.6 µM -1.63288926830626 0.0433251390791432 no 3207 0.0512461438068402 1019 17250992
SGTC_2359 9039622 200 µM -1.63351564861672 0.0432646931770228 no 3208 0.0511802961351213 1058 6463596
SGTC_668 1682-0499 62.6 µM -1.6378636197564 0.0428469873468561 no 3209 0.0507250732722734 1052 682214
SGTC_2367 9070478 135.38 µM -1.64640459350047 0.0420359545650422 no 3210 0.0498402440003013 1029 572802
SGTC_1274 0865-0114 173 µM -1.64815906405102 0.0418709020174559 no 3211 0.0496600173216134 1041 870624
SGTC_2122 5258151 111.688 µM -1.64981076506812 0.0417159974723794 no 3212 0.0494908231511071 1049 2173356
SGTC_1424 4048-1941 275 µM -1.65670506281136 0.0410744218472385 no 3213 0.0487895594678223 1034 X1424
SGTC_2759 disulfiram 3.38 µM -1.65939570189699 0.0408262148393534 no 3214 0.0485180409121969 1021 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2239 6685329 187.64 µM -1.66789111625526 0.0400505039033569 no 3215 0.0476686717635046 1013 805680
SGTC_2316 5844804 197.44 µM -1.67389539281249 0.0395095137396522 no 3216 0.0470755799129775 1031 776813
SGTC_2386 9075165 157.42 µM -1.67554322859854 0.0393620864176902 no 3217 0.0469138484462189 1044 16452277
SGTC_1294 1000-1494 117 µM -1.68256413350258 0.0387389539294403 no 3218 0.0462297499115789 1048 712797 YDL207W GLE1
SGTC_1741 st038134 10.228 µM -1.68562193132796 0.0384700862641894 no 3219 0.0459343211346459 1042 1272587
SGTC_1395 3486-0190 4.35 µM -1.68710495026502 0.0383402353730889 no 3220 0.0457915866833458 1046 6748079
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.68788773189895 0.038271840413346 no 3221 0.0457163910368745 1047 97141
SGTC_2883 9059145 45.46 µM -1.69086962262007 0.0380122106975301 no 3222 0.0454308531155381 1052 16476510
SGTC_1732 st034308 51.822 µM -1.70647286302607 0.036676989230028 no 3223 0.0439600373217745 1026 830119
SGTC_2942 9052777 62.25 µM -1.71027475588333 0.0363575284863714 no 3224 0.0436075388002896 1048 6469503
SGTC_3165 9101544 49.47 µM -1.71042942489814 0.0363445805132441 no 3225 0.0435932468454893 1051 5002184
SGTC_570 0987-0065 62.6 µM -1.71177258795374 0.0362322974952584 no 3226 0.0434692928013363 1016 3104428
SGTC_325 2810-4341 181 µM -1.71746942026466 0.0357592177177317 no 3227 0.0429467185609572 1035 774970
SGTC_993 3909-8757 62.7 µM -1.72417543968989 0.0352088311222086 no 3228 0.0423380882457203 1046 4288324 YLR208W SEC13
SGTC_385 1494-0393 12.4 µM -1.72613838592286 0.035049046467697 no 3229 0.0421612597343102 1053 3090647
SGTC_2526 patulin 37.61 µM -1.73055646830074 0.0346915890497807 no 3230 0.0417654507633258 1035 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2145 5634607 200 µM -1.73476996708312 0.0343534785517991 no 3231 0.04139077887403 1055 308662
SGTC_1141 3253-0389 52.6 µM -1.73773708192285 0.0341170122931334 no 3232 0.0411285757776927 1040 5402031
SGTC_99 0109-0120 622.8 µM -1.74000012336575 0.0339375586301097 no 3233 0.04092949814778 1045 759414
SGTC_1879 gemcitabine 100 µM -1.74075013277856 0.033878256276459 no 3234 0.0408636932363061 1050 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1042 0350-0096 82 µM -1.75066343614162 0.0331024020526282 no 3235 0.040001950591549 1047 3122515
SGTC_78 0336-0123 156.75 µM -1.75119495479925 0.0330612202361842 no 3236 0.0399561671142566 1043 6765896
SGTC_1392 3455-1037 33.9 µM -1.75520216710973 0.0327521003112761 no 3237 0.0396123666816295 1033 981132
SGTC_1770 st043884 66.3 µM -1.75842179453359 0.0325054653201049 no 3238 0.0393378837374376 1054 670149
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.76532230992486 0.0319820199199383 no 3239 0.0387548060339752 1059 6708561
SGTC_2558 carylophyllene oxide 100 µM -1.76702521641964 0.0318539207118983 no 3240 0.0386120026688402 1061 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2438 5259590 200 µM -1.7675718768319 0.0318128887774769 no 3241 0.0385662515060366 1045 1201127
SGTC_2431 5490079 200 µM -1.76815525119879 0.0317691492901401 no 3242 0.0385174764114637 1059 5722345
SGTC_419 nsc-638432 893 µM -1.77120538349259 0.03154126867142 no 3243 0.0382632771828914 1051 368090
SGTC_2686 alizarin 95.37 µM -1.77181714878458 0.0314957256936587 no 3244 0.0382124574807792 1041 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1331 1472-0049 76.2 µM -1.77275267079932 0.0314261857239884 no 3245 0.0381348495733267 1045 24051409
SGTC_1373 2887-0003 58.5 µM -1.77500425668701 0.0312593393355182 no 3246 0.0379485921703365 1047 776948
SGTC_2333 9017922 200 µM -1.77965464731854 0.0309170560967774 no 3247 0.0375662484775232 1035 3163164
SGTC_2832 7992762 51.95 µM -1.78027409512032 0.0308716978076664 no 3248 0.0375155572251374 1021 2985177
SGTC_1642 st009582 77.7 µM -1.78518800717034 0.0305138308812635 no 3249 0.0371154132929141 1054 6739311
SGTC_2801 7907800 81.82 µM -1.78550677674433 0.0304907349378868 no 3250 0.0370895765577122 1027 6620925
SGTC_208 k072-0098 12.366 µM -1.78715205291257 0.0303717592105533 no 3251 0.0369564581710856 1046 5948901
SGTC_2151 5563267 85.4165 µM -1.79034520997178 0.0301419484548492 no 3252 0.0366992162554407 1064 5310824
SGTC_1745 st081495 74 µM -1.7983439090183 0.02957260599304 no 3253 0.036061262770465 1028 13842402 YBL026W LSM2
SGTC_3147 9097027 49.47 µM -1.80307263349344 0.02924023667979 no 3254 0.035688404194356 1053 25236841
SGTC_1844 rapamycin 4 nM -1.8192711559328 0.0281251208373268 no 3255 0.0344350358385398 997 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_46 0329-0187a 2.197 µM -1.82285513691409 0.0278832413962616 no 3256 0.0341626671332986 1051 46494817
SGTC_3310 9130229 44.1445 µM -1.82736348358262 0.0275814407354489 no 3257 0.0338225679751653 1060 7761258
SGTC_2528 xanthyletin 44.79 µM -1.83240909030452 0.0272469085082935 no 3258 0.0334452473713834 1049 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3167 9103034 49.47 µM -1.83324060660795 0.027192103770405 no 3259 0.033383398801397 1070 5127859
SGTC_1325 1431-0015 227 µM -1.83424045017579 0.0271263264931275 no 3260 0.0333091547070538 1057 1103340
SGTC_1503 4585-0012 61.3 µM -1.83527131335203 0.0270586475739719 no 3261 0.03323274965929 1053 2922052
SGTC_2694 st077685 81.9 µM -1.83747110631015 0.0269146964134506 no 3262 0.0330701890585412 1044 2838096
SGTC_1118 chelidonine 707.474 nM -1.83982556279278 0.0267613331781683 no 3263 0.0328969255936517 1064 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1102 cgs 12066b 26.1 µM -1.84357818874998 0.0265184056407048 no 3264 0.0326223185620307 1062 6438352 A 5-HT1B full agonist.
SGTC_3321 9137793 26.8275 µM -1.84488109286853 0.0264344937728228 no 3265 0.0325274188053285 1058 4904192
SGTC_1193 1488-0126 41.5 µM -1.84916141044257 0.0261603857991212 no 3266 0.0322172545413307 1054 1384710
SGTC_2930 9013230 14.89 µM -1.84927901137751 0.0261528884073234 no 3267 0.0322087674125086 1036 2995857
SGTC_2062 5245942 200 µM -1.85383560392793 0.0258637732890847 no 3268 0.0318813415317392 1061 1376160
SGTC_2648 atorvastatin 78.68 µM -1.85815623966918 0.025592104560754 no 3269 0.031573415138865 1058 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2188 6126565 140.678 µM -1.86008473608472 0.0254716198809875 no 3270 0.0314367691891375 1051 874518
SGTC_1911 st060208 74.3 µM -1.86834546893883 0.0249608851822725 no 3271 0.0308569663481353 1053 688783
SGTC_1241 0364-0022 50.8 µM -1.8750762499074 0.0245511164181088 no 3272 0.0303911171930175 1056 4563895
SGTC_1539 benzyladenosine 56 µM -1.8764775476499 0.0244665194998424 no 3273 0.030294867456948 1050 92208 A nucleotide analog.
SGTC_587 k089-0003 57 µM -1.87965000898938 0.024275900423627 no 3274 0.0300778964443294 1046 9659696
SGTC_962 1254-0300 21.5 µM -1.88521760115618 0.0239443835854507 no 3275 0.0297002327167142 1056 7340576
SGTC_2977 9011197 71.43 µM -1.89144082759005 0.0235783391318365 no 3276 0.0292827614303485 1040 2704722
SGTC_271 rotenone 740 µM -1.89660964996598 0.0232779025211544 no 3277 0.0289397380168694 1065 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2805 7950783 58.44 µM -1.89750971921207 0.0232259170022821 no 3278 0.0288803486303944 1051 1178958 YDL195W SEC31
SGTC_2371 9071574 200 µM -1.8997317650606 0.0230979960747768 no 3279 0.0287341647556566 1070 45596039
SGTC_1881 5652484 16 µM -1.92413145901338 0.0217319380966073 no 3280 0.0271690538615081 1061 2255129
SGTC_2479 5617353 43.85 µM -1.92737226375876 0.0215557370635466 no 3281 0.0269666268281688 1048 2731746
SGTC_2297 7971671 152.32 µM -1.93457625014033 0.021168380908102 no 3282 0.0265211583926451 1047 909016
SGTC_1940 st075990 51.1 µM -1.94747866542652 0.020489334645103 no 3283 0.025738687540663 1067 1084979
SGTC_1795 st049545 62.3 µM -1.94897420861897 0.0204118321267594 no 3284 0.0256492524282263 1049 5291882
SGTC_2339 9000433 200 µM -1.95523524164198 0.0200900626732712 no 3285 0.0252776553668547 1052 2988954
SGTC_2373 9071805 200 µM -1.95919763378216 0.0198886568744338 no 3286 0.025044823073301 1070 10149009
SGTC_54 0159-0055 9 µM -1.96720260077114 0.019486993132186 no 3287 0.0245799291588137 1065 3319099
SGTC_905 2-aminofluorene 215 µM -1.9729539035175 0.0192026830363936 no 3288 0.0242504072144591 1056 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1111 tnp00062 510.699 nM -1.97897805885713 0.018908673269051 no 3289 0.0239092383238239 1060 676306
SGTC_553 k007-0256 45.7 µM -1.98242071735701 0.0187423797162571 no 3290 0.0237160863807573 1070 6287000
SGTC_838 0109-0203 71.4 µM -1.98595351438858 0.0185730276643998 no 3291 0.0235192428928967 1059 759422
SGTC_1348 1493-0373 93.8 µM -1.99356230114783 0.0182127049351333 no 3292 0.0230999543413365 1067 3010129
SGTC_879 0831-1030 162 µM -1.99424106118519 0.0181808528606817 no 3293 0.023062858412602 1062 1549252
SGTC_1790 st045711 43.5 µM -1.99747722696934 0.0180296417629349 no 3294 0.0228866829552475 1052 585119
SGTC_857 0438-0306 1.35 µM -2.0162244572442 0.0171746083742083 no 3295 0.0218882550468062 1066 4686136
SGTC_860 0443-0016 25.1 µM -2.02457106141574 0.0168052239275127 no 3296 0.021455714137823 1065 5337942
SGTC_1150 3909-7983 10.9 µM -2.02771796579863 0.0166677303889055 no 3297 0.021294520483167 1066 23965914
SGTC_2214 7179297 48.276 µM -2.03445738971515 0.0163765086478509 no 3298 0.0209527503000567 1082 769744
SGTC_2964 9083345 53.42 µM -2.03599729973201 0.0163105814922919 no 3299 0.0208753132098086 1055 17741579
SGTC_1384 3089-0840 101 µM -2.05231628215191 0.0156257836167955 no 3300 0.0200694673219805 1062 1069836
SGTC_1068 loratadine 26.9 µM -2.05867578577124 0.0153656779911589 no 3301 0.0197626536797677 1076 3957 A H1 histamine antagonist.
SGTC_982 1491-0518 27.5 µM -2.07001657048268 0.0149110573145111 no 3302 0.0192253963671568 1072 3091256
SGTC_2152 5568786 200 µM -2.10537184765805 0.0135672330560427 no 3303 0.0176294762000308 1070 5399883
SGTC_137 0438-0332 85.389 µM -2.10864007352993 0.0134484602469456 no 3304 0.0174878305511525 1054 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1887 st057648 70.8 µM -2.13957909556644 0.0123678599525418 no 3305 0.016194398752287 1071 688672
SGTC_2885 9057732 51.95 µM -2.14497983761489 0.0121871493560912 no 3306 0.0159772295438516 1068 6471414
SGTC_445 e6 berbamine 66 µM -2.14775529122867 0.0120951751775119 no 3307 0.0158666002141702 1060 6610268 A calcium/calmodulin antagonist.
SGTC_2362 9071156 126 µM -2.1637728007358 0.0115760508339852 no 3308 0.01524089529056 1075 653133
SGTC_2116 5511452 16.8835 µM -2.17430681913357 0.0112452886430522 no 3309 0.0148410503218653 1081 870744
SGTC_1659 st012954 42.1 µM -2.17821964474909 0.0111245374848841 no 3310 0.014694844103658 1068 24207262
SGTC_1955 wogonin 32.4 µM -2.17844370912652 0.011117657042326 no 3311 0.0146865093793683 1064 5281703 A flavanone.
SGTC_1956 st077085 54 µM -2.19319050452516 0.0106728820010262 no 3312 0.0141468281969964 1072 24208685
SGTC_2383 9036125 200 µM -2.20693792547896 0.0102722874071766 no 3313 0.0136591981828299 1076 79580
SGTC_877 0771-0151 33.1 µM -2.21258100788334 0.0101116846761391 no 3314 0.0134632727994919 1080 6166523
SGTC_2019 4016004 108 µM -2.214733184162 0.0100510131123278 no 3315 0.0133891918667002 1062 45595336
SGTC_1602 st001878 87.6 µM -2.22498145571786 0.00976644445918914 no 3316 0.0130412415379018 1069 595405 YLR310C CDC25
SGTC_309 k408-0051 1.48 µM -2.24128684833508 0.00932818560802507 no 3317 0.0125037501547727 1061 3640463
SGTC_2795 7780010 54.55 µM -2.24244840782538 0.00929763201741995 no 3318 0.0124662030890625 1059 953673
SGTC_2026 5148700 152 µM -2.24250027531929 0.00929626974269774 no 3319 0.0124645287673203 1078 79838
SGTC_2017 5132927 60.65 µM -2.24818832912397 0.00914793151584689 no 3320 0.0122820917818767 1071 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2557 derrustone 83.84 µM -2.2933818748003 0.00804117538268929 no 3321 0.0109130146061576 1068 629853 An antioxidant.
SGTC_1041 0206-0046 107 µM -2.30800268082198 0.00770924247924297 no 3322 0.0104994936926132 1080 50494
SGTC_2134 5324836 1.464 µM -2.31070109218563 0.00764931702464849 no 3323 0.0104246854399535 1075 699272
SGTC_2005 4024620 188 µM -2.31182799238792 0.00762441282512262 no 3324 0.0103935820827262 1079 236743
SGTC_83 0170-0301 39.027 µM -2.32186529424751 0.0074057223596631 no 3325 0.0101200950426043 1087 3089716
SGTC_2781 5567276 71.43 µM -2.34598039692462 0.00690275486095178 no 3326 0.00948855276614689 1069 2853274
SGTC_146 3448-8650 53.125 µM -2.34641247837382 0.00689402497762269 no 3327 0.00947755868830187 1084 2891488 YIL048W NEO1
SGTC_2334 9017922 200 µM -2.35272833556249 0.0067675260969526 no 3328 0.00931812195364449 1071 3163164
SGTC_2284 7945075 39.21 µM -2.36241540639882 0.00657748975289756 no 3329 0.00907814231101772 1071 1245402
SGTC_2496 diffractaic acid 79.83 µM -2.37294703704151 0.00637625314283075 no 3330 0.00882339706289873 1075 94870 An apoptosis inducer which activates caspases.
SGTC_141 0443-0274 32.331 µM -2.39944150822363 0.00589390343796386 no 3331 0.00821005147087277 964 1627241
SGTC_2601 securinine 100 µM -2.42304952115884 0.00549166474702512 no 3332 0.00769541423579978 1072 442872 A GABA receptor antagonist.
SGTC_260 nsc-65238 3.989 µM -2.42515289360484 0.00545703886389505 no 3333 0.00765097039906865 1083 3246252
SGTC_382 3229-0966 23.2 µM -2.48193598570589 0.00459269293707199 no 3334 0.00653353737844394 1082 5722370
SGTC_2049 5262831 67.185 µM -2.50283955516332 0.00430667800939796 no 3335 0.00616006906380575 1073 763417
SGTC_880 0833-0487 87.2 µM -2.50435275341154 0.00428660517357832 no 3336 0.0061337828173851 1086 76075
SGTC_503 tyrphostin 8 294 µM -2.50451839280063 0.0042844130252738 no 3337 0.00613091148613227 1085 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1228 0124-0032 52.5 µM -2.54006036583244 0.00383658048840416 no 3338 0.00554166686412085 1084 X1228
SGTC_539 4859-0462 2.54 µM -2.56633922908418 0.00353294084628311 no 3339 0.00513891289836328 1069 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_667 1498-1044 59 µM -2.56772030419204 0.00351759705436356 no 3340 0.00511848587828442 1091 6739982
SGTC_149 3970-0822 46.1 µM -2.59938056587293 0.00318186938280124 no 3341 0.0046696085568059 1079 3114250 YBL034C STU1
SGTC_778 3456-2434 196 µM -2.63449786764178 0.00284344556288529 no 3342 0.00421309165356027 990 5539063
SGTC_3225 9130819 49.47 µM -2.63677019450954 0.00282270869651727 no 3343 0.00418497564790003 1089 4547121
SGTC_2059 5238311 157 µM -2.67447078092909 0.0024979988662662 no 3344 0.00374236491082347 1080 703021
SGTC_1775 st081588 35.1725 µM -2.70029862505965 0.00229546046559778 no 3345 0.00346386310503363 1064 1426443 YGL099W LSG1
SGTC_2105 5350118 200 µM -2.78228769120523 0.00174718414451055 no 3346 0.0026988584323931 1087 2133313
SGTC_3256 9138902 49.47 µM -2.82961214567945 0.001487866269286 no 3347 0.00233022317839761 1094 17228773
SGTC_1661 st013063 9.66 µM -2.97641487237127 0.000890786380518035 yes 3348 0.0014582001813646 1088 721395
SGTC_1840 st055363 71 µM -3.0086022427389 0.000793668757787243 yes 3349 0.00131226237821253 1092 676033
SGTC_366 0181-0206 4.31 µM -3.18765876718682 0.000409513411029721 yes 3350 0.000717148457818856 1088 274874
SGTC_1199 1638-0010 4.46 µM -3.4832046964054 0.000127746772784178 yes 3351 0.00024772469090237 1093 3111136
SGTC_1950 st077106 7.18 µM -3.52477870594813 0.000107649504839748 yes 3352 0.000211918349166103 1086 13831864
SGTC_1951 sophoraflavanone G 9.2 µM -3.60407618948284 7.72761199795916e-05 yes 3353 0.00015663258009305 1091 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1257 0669-0121 16 µM -4.66338057581242 4.88523953880525e-07 yes 3354 1.5552836503642e-06 1095 4307855
SGTC_2965 9082772 38.63 µM -4.77215877974813 2.71509767585464e-07 yes 3355 9.11308624068881e-07 1051 16459634
SGTC_2133 5320837 200 µM -4.80419746333721 2.27826915550494e-07 yes 3356 7.76867176111839e-07 1095 2841355