SGTCid condition conc unit ERG27|YLR100W.score ERG27|YLR100W.strain.pval ERG27|YLR100W.strain.significant ERG27|YLR100W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_664 1222-0054 14.9 µM 11.0400406433833 1.58046766455736e-31 yes 1 1.22461176967623e-28 1 6813991 SGTC_1820 st053765 18.6 µM 8.22171483506259 2.48132227056893e-18 yes 2 1.00306871838119e-16 1 3690829 SGTC_676 falcarinol 140 µM 4.71688726035776 3.47576039145516e-07 yes 3 1.19740151907796e-06 5 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_841 0251-0215 91.2 µM 4.39047706985278 1.92874427519394e-06 yes 4 5.65511211565943e-06 2 3888614 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 4.28991693672202 3.19584975374136e-06 yes 5 8.93699783994935e-06 3 7104 SGTC_1861 st057647 17.4 µM 4.26580056523361 3.60151462275876e-06 yes 6 9.95933272493087e-06 5 688668 SGTC_778 3456-2434 196 µM 4.04519655242204 1.04410314188285e-05 yes 7 2.61396215240469e-05 6 5539063 SGTC_2986 9022445 71.43 µM 3.72116700006716 4.53981956344304e-05 yes 8 9.91521189292519e-05 7 6459286 SGTC_2928 9011484 9.79 µM 3.62052217446564 7.00618696585905e-05 yes 9 0.000147004525331343 35 2994751 SGTC_1383 3049-0032 20.7 µM 3.56414484130746 8.8923045576498e-05 yes 10 0.000182522175390119 14 712864 SGTC_674 0498-0004 451 µM 3.53324205719245 0.00010119253723632 yes 11 0.000205248221390489 29 4231473 SGTC_1993 st073995 70.8 µM 3.50093059739949 0.000115711118706087 yes 12 0.000231818284039346 8 3098394 SGTC_1054 3429-0080 167 µM 3.49870016832476 0.000116782249593879 yes 13 0.000233766003532597 7 1162877 SGTC_1668 st014914 51.6 µM 3.41871356249412 0.000161951917156811 yes 14 0.000314589608410849 10 2839556 SGTC_194 1486-1323 56.904 µM 3.37547245701102 0.000192727289421897 yes 15 0.000368445338183613 13 5178754 SGTC_152 4469-0003 551.229 µM 3.35984622676615 0.000205134327655689 yes 16 0.000389929331498615 24 697280 SGTC_3073 9114972 49.47 µM 3.28274939375009 0.000278032789902513 yes 17 0.000514000046613805 11 41905075 SGTC_1779 st039427 55 µM 3.2806496215692 0.000280320538125688 yes 18 0.000517841579840948 7 1124498 SGTC_1364 1653-0028 37.6 µM 3.28018227844548 0.000280832098432159 yes 19 0.000518700191006647 7 5718652 SGTC_74 000s-0487 160.283 µM 3.2765645190002 0.000284821664125305 yes 20 0.000525391509154714 7 677548 SGTC_216 k038-0035 28.382 µM 3.25212461016242 0.000313187019906934 yes 21 0.000572728958767402 27 4444231 YPR107C YTH1 SGTC_670 4204-0025 119 µM 3.24354583623374 0.000323751754252119 yes 22 0.00059025907293345 6 719039 SGTC_1847 st056231 15 µM 3.18640318552329 0.00040302735817518 yes 23 0.000720268458023122 11 5393180 SGTC_1155 4088-0394 48.2 µM 3.18533213298361 0.000404672167894993 yes 24 0.000722939804540452 13 2326248 SGTC_2790 5423970 71.43 µM 3.16468755535494 0.000437618577424964 yes 25 0.000776247832561626 26 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3151 9099821 49.47 µM 3.13523713691692 0.000488938045883624 yes 26 0.000858576211883344 12 17174189 SGTC_3202 9113761 49.47 µM 3.13065868037023 0.000497399597068239 yes 27 0.000872073720061222 26 4798415 SGTC_786 4544-0069 423 µM 3.1247200588639 0.000508576900417749 yes 28 0.000889871723624231 17 748821 YLR208W SEC13 SGTC_2157 5649910 96.377 µM 3.11983723368841 0.000517940724151288 yes 29 0.000904754988901852 15 2858091 SGTC_1805 st050013 60.3 µM 3.0972373303653 0.000563394993501132 yes 30 0.000976667100938814 7 4037144 SGTC_2493 resveratrol 26.09 µM 3.05356081353941 0.000661855544161615 yes 31 0.00113071440688047 5 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_64 000l-0018 272.079 µM 3.03068188030715 0.000719551239292753 yes 32 0.00122001089525287 70 6811119 SGTC_338 4055-0136 114 µM 3.02111145540471 0.000745033328161784 yes 33 0.00125924318609276 7 2900563 SGTC_2502 avocadyne acetate 18.59 µM 3.01858548920354 0.000751896254017182 yes 34 0.00126978869580892 14 3952079 SGTC_1945 st075991 56.6 µM 2.98517083445344 0.000848332836992 yes 35 0.00141709994937959 24 1084980 SGTC_770 0389-1121 67.2 µM 2.96604144922614 0.000908538159028274 yes 36 0.00150829915497774 23 6753108 SGTC_2437 5741531 144.16 µM 2.93068226803833 0.00103026862378656 no 37 0.00169109258161012 26 2262990 SGTC_227 fluconazole 33.516 µM 2.90625675437784 0.0011229085416012 no 38 0.00182890585674236 68 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2980 9014342 25.29 µM 2.87019543335726 0.00127368714373839 no 39 0.00205109085594867 36 2996599 SGTC_1846 st056244 14.8 µM 2.86900801338532 0.00127895306814054 no 40 0.00205880683212927 15 5393182 SGTC_18 0111-0177 500 nM 2.81997892772252 0.00151456994196357 no 41 0.00240134016004058 16 721752 SGTC_3082 9117008 49.47 µM 2.81416570807299 0.00154498731651281 no 42 0.00244520060393761 10 41448529 SGTC_548 1436-0017 110 µM 2.7973010478615 0.00163640956602593 no 43 0.00257657465545354 21 9677137 SGTC_766 1391-0721 126 µM 2.79436658468961 0.00165281146780853 no 44 0.00260007465397759 17 1020919 YIL115C NUP159 SGTC_355 1311-2252 105 µM 2.76964348927596 0.00179705851078542 no 45 0.00280588399431085 19 5338538 SGTC_1388 3346-4487 254 µM 2.71549462488734 0.00215376957030418 no 46 0.00330884253263876 11 3345614 SGTC_764 1951-2361 146 µM 2.69201272056074 0.00232752487411519 no 47 0.00355111181643466 34 5438930 SGTC_403 arphamenine a 50 µM 2.68595423960629 0.00237436806635225 no 48 0.00361614965925747 21 5487158 An arginine aminopeptidase inhibitor. SGTC_1827 berberine 7.24 µM 2.6787186799313 0.00243142932153923 no 49 0.00369522282173756 23 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3194 9111903 49.47 µM 2.65366822787078 0.00263869294308771 no 50 0.00398110351365352 16 17087251 SGTC_2718 lomofungin 53.02 µM 2.62954850531615 0.00285320222408099 no 51 0.00427491669687145 23 5351222 A RNA synthesis inhibitor. SGTC_1980 st071811 45.7 µM 2.62367636280592 0.00290775170818908 no 52 0.00434931985153804 17 4974850 SGTC_1131 3454-3128 32.3 µM 2.62204422868707 0.00292307955812632 no 53 0.00437020436218179 33 710982 SGTC_2183 6420625 130.508 µM 2.61010656015825 0.00303742248980764 no 54 0.0045257011436909 45 2897619 SGTC_2863 9028737 58.44 µM 2.57043868164011 0.0034468812373138 no 55 0.00507849029918583 9 6460917 SGTC_266 formosanin C 406 nM 2.53316975737419 0.00387606556536502 no 56 0.00565180979599618 46 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2447 5741742 33.78 µM 2.53271941048778 0.00388153227269296 no 57 0.00565907557504503 37 1776504 SGTC_1132 3456-3614 2.5 µM 2.50309214763734 0.00425670982264011 no 58 0.00615567427327325 30 3125502 SGTC_3186 9110464 49.47 µM 2.47686019556037 0.00461561141240524 no 59 0.0066271904317776 13 17018021 SGTC_1092 toremifene 6.32 µM 2.44903395622309 0.00502561682049244 no 60 0.00716199718140284 26 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1453 4237-0541 195 µM 2.44369353045336 0.00510791617831915 no 61 0.00726888504368619 41 739892 SGTC_2131 toluylene red 5.2905 µM 2.43893544173187 0.00518224975260306 no 62 0.00736529980090673 42 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2860 9025725 38.96 µM 2.42879644002077 0.00534386628082313 no 63 0.00757451757043259 27 40546248 SGTC_1483 3453-0561 55.9 µM 2.42039046708469 0.00548124020312128 no 64 0.00775192463977326 32 4546991 SGTC_562 3772-2733 112 µM 2.39856164933406 0.00585273895984001 no 65 0.0082298027622332 34 2876874 YIL048W NEO1 SGTC_2006 4011487 200 µM 2.39666807156802 0.00588599456668115 no 66 0.00827245189684216 53 45595294 SGTC_1301 naphtanilide LB 4.81 µM 2.39511794044486 0.00591334310129142 no 67 0.00830750994109959 47 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3329 9141233 27.5565 µM 2.38927599105992 0.00601742633372711 no 68 0.00844080762338545 22 4909101 YNL103W MET4 SGTC_2685 mycophenolic acid 18.85 µM 2.37326558115632 0.00631104651535569 no 69 0.00881579054359535 16 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3216 9129716 49.47 µM 2.36696887888405 0.00642995484421859 no 70 0.00896722040842737 27 8056934 SGTC_24 0417-1663 219 µM 2.3568587372785 0.00662502632233828 no 71 0.00921512819949697 20 4329390 SGTC_2233 sulbentine 40.3845 µM 2.35082215339861 0.00674397847582225 no 72 0.00936599230800978 69 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1171 0368-0077 21.4 µM 2.34550577155208 0.00685029775565301 no 73 0.00950064220203182 54 3239779 SGTC_3117 9124945 49.47 µM 2.3391068536363 0.00698022726537227 no 74 0.00966495203474545 17 17592065 SGTC_16 erodoxin 22.806 µM 2.33739910284175 0.0070152687173554 no 75 0.00970922087164062 65 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3253 9135987 49.47 µM 2.33082801870996 0.00715155356025549 no 76 0.00988121503159239 34 4182430 SGTC_217 ketoconazole 989 nM 2.3168109240044 0.00745009802084862 no 77 0.0102570168534049 30 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1480 1070-0044 41.2 µM 2.31518730724046 0.00748537868495417 no 78 0.0103013417936748 30 3124987 SGTC_2113 5491891 107.031 µM 2.30727936048902 0.00765932825840981 no 79 0.0105196256849008 40 789979 SGTC_277 nystatin 15.5 µM 2.28079612868097 0.00826806038585416 no 80 0.0112802567896576 28 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2852 9023854 51.95 µM 2.28034206252397 0.00827885770092457 no 81 0.0112937044711397 40 19798528 SGTC_425 3825-7017 13.1 µM 2.2535017385868 0.00893950288987594 no 82 0.012113765616373 51 3397440 SGTC_3062 9077494 49.47 µM 2.25154120700687 0.0089895212435628 no 83 0.0121756400183756 36 16459633 SGTC_2461 5755302 26.15 µM 2.24538180124594 0.00914826239801685 no 84 0.0123718163477377 37 2788904 SGTC_943 3253-1379 105 µM 2.23411606824146 0.00944496176001263 no 85 0.0127377185098637 42 668464 SGTC_1418 3966-3099 2.4 µM 2.23350899758694 0.00946118612064659 no 86 0.0127576988240028 44 740335 SGTC_89 0302-0250 142.109 µM 2.23111176779562 0.00952549203240708 no 87 0.0128368632233268 44 4203518 YLR208W SEC13 SGTC_1399 3562-5772 25 µM 2.22691032891403 0.00963911811096003 no 88 0.0129766336958545 39 23847490 SGTC_1834 st055981 52.8 µM 2.22396444509842 0.00971949305099389 no 89 0.0130754182514353 43 471719 YDL150W RPC53 SGTC_1014 4130-3005 69.3 µM 2.22030926619498 0.00982003380059211 no 90 0.01319889067929 35 743608 SGTC_2884 9058502 51.95 µM 2.21411243866974 0.00999256230986175 no 91 0.0134105225912013 34 6471554 SGTC_2916 7875993 68.79 µM 2.19481367346631 0.0105469289655651 no 92 0.014088483121677 45 1299250 SGTC_3127 9126946 49.47 µM 2.193616431797 0.0105821863840916 no 93 0.0141314980586586 46 27243249 SGTC_2851 9015922 71.43 µM 2.1917581499212 0.0106371140551068 no 94 0.0141984872212582 42 2996893 SGTC_948 3448-0295 75.3 µM 2.1870343478032 0.010777860964603 no 95 0.0143700083252401 45 678569 SGTC_2808 7946468 45.46 µM 2.18680006965955 0.0107848833454025 no 96 0.0143785611969074 53 2970879 SGTC_2506 ethyl hematommate 54.16 µM 2.18539852861163 0.0108269771499927 no 97 0.0144298193331816 27 3940691 An allergen. SGTC_956 1185-0240 191 µM 2.18165539999308 0.0109400997735312 no 98 0.0145674874357091 29 1416193 SGTC_1125 tnp00248 1.32998 µM 2.1806499903331 0.0109706593380072 no 99 0.0146046573041366 55 24207736 SGTC_268 camptothecin 39.6153 µM 2.17938043103441 0.0110093538484676 no 100 0.0146517093180931 96 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2118 5526350 200 µM 2.17731005414566 0.0110727109328868 no 101 0.014728720765566 43 743594 SGTC_1769 st044406 64.4 µM 2.16876860189659 0.0113374584944424 no 102 0.0150501280589837 66 670903 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 2.16800920781886 0.0113612604900922 no 103 0.0150789929837913 40 689007 SGTC_2983 9022671 12.99 µM 2.16468989593767 0.0114658094177575 no 104 0.0152057206910593 35 6405161 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 2.15098040565025 0.0119065222481932 no 105 0.0157388731508118 53 4330530 SGTC_2950 9072895 21.46 µM 2.14670337840957 0.012046987903185 no 106 0.0159084518231855 39 17332245 SGTC_345 1362-0200 395 µM 2.14227216397467 0.0121940305935327 no 107 0.016085793717383 43 1419823 SGTC_459 nigericin 15.3 µM 2.13409460306894 0.0124694767771911 no 108 0.0164175187914432 55 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1978 st071761 42 µM 2.12314051407353 0.0128468768813753 no 109 0.0168710394648943 48 5147680 SGTC_2835 9006588 71.43 µM 2.12174903324998 0.01289551754762 no 110 0.0169294093237234 37 2345538 SGTC_2795 7780010 54.55 µM 2.11427278853002 0.0131595931733292 no 111 0.0172459875521021 50 953673 SGTC_2324 6149169 200 µM 2.1053187179785 0.013482006990029 no 112 0.0176317869168696 40 2888231 SGTC_1825 st052143 62.6 µM 2.10428245282533 0.0135197569869081 no 113 0.0176769078910369 45 674173 SGTC_1360 1598-0022 39.8 µM 2.09996277313254 0.0136781026748976 no 114 0.0178660579983179 61 761525 SGTC_131 0141-0277 33.849 µM 2.09186863891914 0.0139791191796912 no 115 0.0182251340870307 53 1547771 SGTC_2971 9092186 9.93 µM 2.081891544498 0.0143580052091964 no 116 0.018676188648172 52 25236400 SGTC_570 0987-0065 62.6 µM 2.0738559064498 0.0146695608822464 no 117 0.0190463475828875 42 3104428 SGTC_2705 st078069 42.8 µM 2.06737573717028 0.0149250280778741 no 118 0.019349381334395 42 1530061 SGTC_1255 0566-0045 221 µM 2.06604759968376 0.014977856819617 no 119 0.0194119926486522 63 2788469 SGTC_1467 k284-1082 293 µM 2.06439171438296 0.0150439473069358 no 120 0.0194902957173425 41 3334705 SGTC_1764 st044502 93.5 µM 2.05711976161038 0.015337164360515 no 121 0.0198373536282016 44 8407 SGTC_1944 st076371 56.9 µM 2.05200012788483 0.0155465283570081 no 122 0.0200848249933456 40 24208455 SGTC_1860 st056228 74.6 µM 2.04557430981241 0.0158127752411672 no 123 0.0203991355911711 58 688679 SGTC_2543 pimpinellin 60.67 µM 2.04434532935655 0.0158641397513646 no 124 0.0204597220576162 45 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_837 0091-0265 12.5 µM 2.04393052605635 0.0158815084726239 no 125 0.020480205481915 59 759367 SGTC_269 exalamide 29 µM 2.04025708061927 0.0160360365069665 no 126 0.0206623635853658 49 3316 A derivative of salicylamide. SGTC_372 0155-0182 15.9 µM 2.03924558841352 0.0160788117876864 no 127 0.0207127615504598 37 771486 SGTC_1914 st062367 72.6 µM 2.03551439853619 0.016237447796404 no 128 0.0208995706316991 59 978205 SGTC_3059 1327-0034 3 µM 2.03505209905612 0.0162571960519015 no 129 0.020922815524646 59 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3027 9089541 49.47 µM 2.01821820745687 0.0169904436785183 no 130 0.021784270354755 55 9943819 SGTC_2870 9038528 12.99 µM 2.01252852383375 0.0172445843357009 no 131 0.022082126494809 51 6463316 SGTC_1485 3909-9022 254 µM 2.00968890819198 0.0173726314720199 no 132 0.0222320623154991 33 714516 SGTC_322 k048-0136 19.3 µM 2.00718350704098 0.0174862812526413 no 133 0.0223650635487917 56 6823282 SGTC_333 3486-0131 40.1 µM 2.00324056363985 0.0176664261142526 no 134 0.0225757368398405 47 6744690 SGTC_10 0279-0212 42.575 µM 1.99699314342421 0.0179550998040433 no 135 0.022912963917523 40 39851 YBR002C RER2 SGTC_185 k048-0037 25.491 µM 1.97993828977461 0.0187637065650449 no 136 0.0238552316276796 28 6827589 SGTC_718 1130-0073 349 µM 1.9753535022977 0.0189862941796351 no 137 0.0241140227873684 55 6740020 SGTC_1277 0873-0036 22 µM 1.9702051196677 0.0192389167428902 no 138 0.0244074335206831 41 5965735 SGTC_2617 dihydrotanshinone i 20.83 µM 1.96912967032805 0.0192920464393575 no 139 0.0244691012411991 81 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2890 9046729 58.44 µM 1.96280912767211 0.0196068220771551 no 140 0.0248341784067169 71 903329 SGTC_2030 5175110 200 µM 1.95103352842346 0.0202049088540668 no 141 0.0255265287347871 45 2831986 SGTC_1987 st072290 61.9 µM 1.94380920852725 0.0205794366512975 no 142 0.0259592314501557 46 54697379 SGTC_1791 st048313 56.1 µM 1.94314892470576 0.0206139589567501 no 143 0.0259990835800338 38 1204976 SGTC_150 3970-0969 77.2 µM 1.94301781691994 0.0206208196354876 no 144 0.0260070028161662 100 6615640 SGTC_232 clozapine 119 µM 1.93975079610078 0.0207924036680086 no 145 0.0262049915183899 46 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1136 pergolide 1.05886 µM 1.92940698753263 0.0213436539965773 no 146 0.0268401784670104 80 47811 A dopamine receptor agonist. SGTC_1421 4029-0249 71.4 µM 1.91889619831368 0.0219164113972753 no 147 0.0274987359315175 53 2894095 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.91883277286331 0.0219199066100913 no 148 0.0275027504050614 57 16623 A steroid. SGTC_1314 1222-0010 41.1 µM 1.91654525874596 0.0220462805821051 no 149 0.0276478640855409 47 3526027 SGTC_1016 4226-1401 38 µM 1.90970386727052 0.0224279098876904 no 150 0.028085676385488 68 2901613 SGTC_2505 galangin 7.89 µM 1.90026978510642 0.0229632922957067 no 151 0.0286988621828624 68 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1509 1326-1131 80 µM 1.89890134445071 0.0230418379308666 no 152 0.0287887242739992 35 768313 SGTC_1671 st016596 74.5 µM 1.8899365893159 0.0235620116912897 no 153 0.0293832206361148 54 2829167 SGTC_2659 sanguinarine 24.21 µM 1.88083955876385 0.0240999225945759 no 154 0.0299968735657519 50 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_953 1188-0045 9.7 µM 1.87175046339187 0.0246476300379656 no 155 0.0306205672277314 68 6144426 SGTC_2684 capsaicin 100 µM 1.86663520006063 0.0249604418859346 no 156 0.0309762742510658 59 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2114 5491910 81.25 µM 1.86463257590598 0.0250838110305767 no 157 0.03111646172918 63 2849228 SGTC_2248 tofa 1.1 µM 1.86387550497594 0.0251305823768883 no 158 0.0311695946604277 85 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2946 9065502 71.43 µM 1.85711279249012 0.0255516299064311 no 159 0.0316475542854304 36 16489101 SGTC_2708 st078559 56 µM 1.85304254880518 0.0258078797642438 no 160 0.0319381301575911 37 17250902 SGTC_2784 7567673 72.73 µM 1.85039879721814 0.0259754715183809 no 161 0.0321280461239132 69 3471247 SGTC_2743 auranofin 4.32 µM 1.84964122024025 0.0260236630507803 no 162 0.0321826387959291 42 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_84 0443-0269 128.823 µM 1.8471359593044 0.0261835623978065 no 163 0.0323637190061425 57 6150058 SGTC_2467 5474540 200 µM 1.82857200554669 0.0273941921419759 no 164 0.0337318748146654 75 5413519 SGTC_1800 st050079 29.0735 µM 1.82312247526638 0.0277583164786711 no 165 0.0341424216347829 94 3645560 SGTC_2087 5276107 200 µM 1.81974628387721 0.0279859220955761 no 166 0.0343988256828997 61 144405 SGTC_683 panaxydol 45 µM 1.81772064410479 0.0281232249244471 no 167 0.0345534204088594 46 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1578 josamycin 24.2 µM 1.81332972615357 0.0284227783008344 no 168 0.0348904905515242 63 5282165 A P450 substrate. SGTC_1444 4112-3581 28 µM 1.80909422645479 0.0287142397290701 no 169 0.0352181829479572 62 2877249 SGTC_1571 st070080 73.4 µM 1.8020005448503 0.0292079488031962 no 170 0.0357726599197875 49 4315245 SGTC_2588 indole-3-carbinol 100 µM 1.8005735744259 0.0293081108036095 no 171 0.035885058691904 67 3712 Induces cell cycle arrest. SGTC_593 1203-0218 61.7 µM 1.79174671256532 0.0299340448496401 no 172 0.0365867740847757 69 3666956 SGTC_1635 st007035 42.4 µM 1.7896747255595 0.0300825702134888 no 173 0.0367531089062648 79 3716403 SGTC_1663 st014140 55.4 µM 1.78653331519644 0.0303089196315026 no 174 0.0370064740020179 51 4207120 SGTC_230 MPP+ 141.667 µM 1.78559247018698 0.0303769847642818 no 175 0.0370826334876687 72 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3060 1327-0027 12.5 µM 1.78334233806788 0.0305402836445221 no 176 0.0372652967173489 48 16000455 YPR107C YTH1 SGTC_1057 3448-5381 134 µM 1.78261960172068 0.0305928888338681 no 177 0.0373241233939296 83 5497911 SGTC_1368 1852-0141 284 µM 1.7794431024683 0.0308249844580716 no 178 0.0375835726262035 64 2838987 SGTC_612 0302-0167 22.4 µM 1.77754480414923 0.0309643809354605 no 179 0.0377393230008186 75 235821 SGTC_3106 9121286 49.47 µM 1.76909354348997 0.031591322402418 no 180 0.0384391326041483 60 15943471 SGTC_2032 5185112 25.99 µM 1.7672974440143 0.0317259056495789 no 181 0.0385892138423114 52 5718189 SGTC_120 rhodamine 6G 52.259 µM 1.76334671199115 0.0320236047702732 no 182 0.0389210157033506 129 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2894 9048625 32.47 µM 1.76112423456919 0.0321920862158414 no 183 0.0391086890205712 90 4092861 SGTC_756 0508-1999 28.3 µM 1.75713809664297 0.03249609995416 no 184 0.0394471367720775 82 6753853 SGTC_3224 9130643 49.47 µM 1.74598537370602 0.0333592966626019 no 185 0.040406746707684 71 17644395 SGTC_458 nppb 133 µM 1.74210691301748 0.0336638708531163 no 186 0.0407448690858462 49 4549 A chloride channel blocker. SGTC_1534 6-azauridine 81.6 µM 1.7395504860086 0.0338658747473813 no 187 0.0409689899777123 81 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_937 3122-0005 46.7 µM 1.7395424681787 0.0338665098658226 no 188 0.0409696944673142 61 759535 SGTC_817 1391-0715 46 µM 1.73919701474344 0.0338938836653678 no 189 0.041000057194821 98 1353946 SGTC_417 st075190 100 µM 1.73651410848374 0.0341070978016421 no 190 0.041236485971611 70 222757 SGTC_124 0136-0217 7.121 µM 1.73181973054905 0.0344828186186002 no 191 0.0416528320131802 106 3976905 SGTC_699 0375-0592 111 µM 1.72955814193878 0.0346650379182899 no 192 0.0418546250425857 48 762578 SGTC_3349 9149703 23.001 µM 1.72943129085542 0.0346752818620284 no 193 0.0418659668912621 45 4910494 SGTC_1969 st069479 40.1 µM 1.71957893096978 0.0354785433917681 no 194 0.0427545043438542 58 3895485 SGTC_1103 duloxetine 36.1 µM 1.7147319480383 0.0358792809736511 no 195 0.043197191659442 90 60835 A selective serotonin reuptake inhibitor. SGTC_2698 st077697 67.5 µM 1.71104038614971 0.0361869723547342 no 196 0.0435368288555958 65 3154499 SGTC_495 decylubiquinone 155 µM 1.70376820390558 0.036799428199682 no 197 0.044212200193824 70 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_804 1595-0054 20.9 µM 1.70283628869138 0.0368785223377994 no 198 0.0442993548417591 71 761523 Stimulates phospholipase C. SGTC_51 1013-0126 23.419 µM 1.70083305699947 0.0370490125319411 no 199 0.044487169977482 66 1627850 SGTC_2495 cafestol 54.53 µM 1.69519146262374 0.0375326193478643 no 200 0.0450195529706465 98 16667697 An anti-infammatory. SGTC_3108 9121785 49.47 µM 1.69505051000353 0.0375447677302789 no 201 0.0450329196861103 81 17140271 SGTC_907 3448-6986 75.5 µM 1.69420282251866 0.0376178957019079 no 202 0.0451133743456092 81 590582 SGTC_866 0495-0101 262 µM 1.68879283814224 0.0380873458158602 no 203 0.0456295683980454 87 635694 SGTC_13 0199-0087 65 µM 1.6862518339381 0.0383094844001712 no 204 0.0458736519967888 77 4589825 SGTC_2763 lisinopril 49.32 µM 1.68268586514741 0.0386230072477676 no 205 0.0462179597312066 63 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2221 6807166 181.081 µM 1.68110957780387 0.0387622604771302 no 206 0.0463708161836628 55 674925 SGTC_2238 6671620 73.2395 µM 1.68004804468797 0.0388562692607373 no 207 0.0464739841560689 60 729941 SGTC_493 zm226600 134 µM 1.67606183707547 0.0392109447560049 no 208 0.0468630404554257 83 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1317 1273-0028 910 nM 1.67582825291231 0.0392318095204991 no 209 0.0468859191938901 94 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2066 5222451 176 µM 1.67384723188948 0.039409126529983 no 210 0.0470803135169332 118 2281147 SGTC_1416 3966-0321 25.3 µM 1.66463592172554 0.0402421943222467 no 211 0.0479927070795404 82 582530 YLR208W SEC13 SGTC_1886 st057356 49.9 µM 1.66113364917651 0.0405626682218989 no 212 0.0483433038638913 75 24207747 SGTC_518 1021-0119 62.6 µM 1.65483247484668 0.0411444692465506 no 213 0.0489792422870573 93 1097762 SGTC_1455 4262-0120 131 µM 1.65254619688598 0.0413572318839281 no 214 0.0492116278878631 71 1529587 SGTC_3122 9126309 49.47 µM 1.65076305809421 0.0415237902610404 no 215 0.0493934830664026 92 17591206 SGTC_1053 3366-3204 134 µM 1.64539772951891 0.0420282319289035 no 216 0.0499439087397618 94 3632071 YPR165W RHO1 SGTC_738 1315-0003 72.4 µM 1.64382987920973 0.0421765722670536 no 217 0.0501056738083715 77 6251474 SGTC_3340 9146634 11.102 µM 1.64280351445003 0.0422739098375713 no 218 0.0502117964197989 61 4907387 SGTC_2994 9053520 71.4286 µM 1.64186792451758 0.042362796851179 no 219 0.0503086892471569 69 4647384 SGTC_2418 pentamidine 31.67 µM 1.63855364989311 0.0426788911720476 no 220 0.0506531260369499 93 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3081 9117243 49.47 µM 1.63768967384981 0.0427616042492876 no 221 0.0507432228930334 121 45595589 SGTC_1681 tripelennamine 100 µM 1.63550636926467 0.042971201284276 no 222 0.0509714702935929 71 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_290 2043-6722 48.1 µM 1.6354704557959 0.0429746559008683 no 223 0.0509752315862609 76 773758 YLR208W SEC13 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.63386097135418 0.043129707210868 no 224 0.0511440231889587 83 15053 SGTC_2223 6903751 107.57 µM 1.63243694631433 0.0432672685817632 no 225 0.0512937356492089 68 5598863 SGTC_1371 2421-0008 32.7 µM 1.63039288899363 0.0434653443775598 no 226 0.0515092433047797 102 2827552 SGTC_1215 3852-0577 11.2 µM 1.62796820832418 0.0437012522492088 no 227 0.0517658135157033 72 2884876 SGTC_1 0258-0098 57.368 µM 1.62754490395767 0.043742543127489 no 228 0.0518107098988947 97 6790032 YDR047W HEM12 SGTC_2181 6316240 54.2555 µM 1.62563194669436 0.0439295336711654 no 229 0.0520139874707444 67 12779990 SGTC_327 1273-0057 3.96 µM 1.62527030344345 0.0439649564600482 no 230 0.0520524880784959 76 3108138 SGTC_624 k048-0052 28 µM 1.62196057276716 0.0442902142249821 no 231 0.0524058952195955 72 6835531 SGTC_565 1418-0001 44.5 µM 1.62008759779984 0.0444751350133903 no 232 0.0526067305859387 85 2862145 SGTC_2278 7948257 134.34 µM 1.61691003663789 0.0447902814203012 no 233 0.0529488508035567 68 1247028 SGTC_2475 5812728 15.03 µM 1.6115696470706 0.045323982651335 no 234 0.0535278100699354 95 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2642 cholecalciferol 100 µM 1.59762943724775 0.0467412504425733 no 235 0.0550627355444968 57 9821465 A vitamin D precursor, similar to steriods. SGTC_511 blebbistatin 171 µM 1.59226556685257 0.0472959658311587 no 236 0.0556625231684935 73 3476986 A myosin inhibitor. SGTC_923 1900-2434 73.3 µM 1.5836304008909 0.0482000601795522 no 237 0.0566389257715569 109 5910570 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.58173876142473 0.0483999478448001 no 238 0.0568546100412402 89 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2643 anethole 100 µM 1.57331380681115 0.0492982691243085 no 239 0.0578230869582568 99 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_11 0438-0307 1.3 µM 1.56845294390159 0.0498225905410192 no 240 0.0583877317672304 106 4011476 SGTC_1749 st037932 54.2 µM 1.56839727783742 0.0498286206739425 no 241 0.0583942230067594 97 594497 SGTC_186 3455-3465 67.277 µM 1.56762534314182 0.0499123020039922 no 242 0.0584842970219501 86 755278 SGTC_198 3454-2873 16.191 µM 1.56502031432677 0.050195526919611 no 243 0.0587890730862115 97 710957 SGTC_2360 9040895 200 µM 1.56500481287775 0.0501972161003002 no 244 0.0587908904060682 73 4914414 SGTC_354 2783-3500 4.88 µM 1.56451871728602 0.0502502085467878 no 245 0.0588479004285661 123 6740761 SGTC_3343 9148379 18.9835 µM 1.56367175865434 0.0503426475450899 no 246 0.0589473366457986 70 1955036 SGTC_2991 9074669 71.4286 µM 1.55527928860237 0.0512659624818904 no 247 0.0599397839083928 131 17333109 SGTC_1687 st020778 55.3625 µM 1.55473009263221 0.0513268499993544 no 248 0.0600051822582696 89 4259299 SGTC_1855 st056195 39.6 µM 1.54503230034105 0.0524115167873928 no 249 0.0611692253399032 84 4028379 SGTC_2043 5101342 149 µM 1.54277191560333 0.0526669304708003 no 250 0.0614430629365129 89 678451 SGTC_2426 5582046 32.21 µM 1.54060297022808 0.0529129395176755 no 251 0.0617067222991742 88 2251934 SGTC_959 1222-0044 107 µM 1.53728536356846 0.0532909959029661 no 252 0.0621117220436574 86 6083612 SGTC_1310 1188-0297 994 nM 1.52357719303526 0.0548758530323801 no 253 0.0638071820114157 109 1588352 SGTC_2147 5545932 89.7195 µM 1.52319433623775 0.0549206456666682 no 254 0.0638550463343667 116 797404 SGTC_628 1636-0253 16 µM 1.5147816183418 0.0559122101706751 no 255 0.0649138584990895 104 4456143 SGTC_2344 7990960 76.95 µM 1.50796512049025 0.056725948873565 no 256 0.0657817271068716 124 140813 SGTC_1078 idebenone 36.1 µM 1.50717462755737 0.0568209167952235 no 257 0.0658829509925966 122 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2186 6124449 200 µM 1.50401003779547 0.0572023576053518 no 258 0.066289391094923 101 3834182 YLR033W RSC58 SGTC_2619 obliquin 87.91 µM 1.50361146780419 0.0572505414204371 no 259 0.0663407183143554 112 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2443 5493264 126.67 µM 1.50292195809553 0.0573339728588794 no 260 0.0664295849583959 84 5340055 SGTC_2727 riluzole 51.77 µM 1.50198336465963 0.0574476974225273 no 261 0.0665507025521605 103 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1971 st069429 63.5 µM 1.50009966519007 0.0576764710557179 no 262 0.0667942938379306 66 1246522 YGL099W LSG1 SGTC_313 3474-0040 5.03 µM 1.49573684892674 0.0582090823229609 no 263 0.0673611218684422 122 1043375 YIL048W NEO1 SGTC_788 1182-0090 188 µM 1.48610553752965 0.0593985469252118 no 264 0.0686256039109989 106 5715185 SGTC_918 glabranin 770.725 nM 1.48609199942773 0.0594002321880184 no 265 0.0686273941063826 95 124049 Also referred to as licorice root. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 1.48209403385634 0.0598995528318858 no 266 0.0691576380280358 119 6728940 SGTC_1442 4112-3290 3 µM 1.47970940460418 0.0601989395522324 no 267 0.0694754073572962 84 704353 SGTC_853 0419-0306 21 µM 1.47808158855365 0.0604039813377705 no 268 0.0696929707354869 122 762713 SGTC_208 k072-0098 12.366 µM 1.47736606985195 0.0604942817179495 no 269 0.0697887681188386 119 5948901 SGTC_487 nimodipine 119 µM 1.47729691338343 0.0605030150445148 no 270 0.0697980325169699 58 4497 L-type voltage-gated calcium channels inhibitor SGTC_806 3966-4455 5.86 µM 1.47650328860886 0.0606033074531562 no 271 0.0699044165305241 80 714982 SGTC_1522 st012842 45.6 µM 1.47499911853844 0.060793750085278 no 272 0.070106390201513 105 3491067 YOR116C RPO31 SGTC_1045 1348-1485 165 µM 1.46806867084508 0.0616772643855286 no 273 0.0710427852893625 104 6810614 SGTC_2139 5578692 56.4705 µM 1.46601039580767 0.061941581238527 no 274 0.0713227273693353 114 650991 YMR113W FOL3 SGTC_2759 disulfiram 3.38 µM 1.46586703506566 0.0619600240283859 no 275 0.071342257089848 121 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2027 5150920 200 µM 1.46014460049012 0.0626996977714431 no 276 0.0721251685643825 86 786715 SGTC_2561 acetosyringone 100 µM 1.45996598267845 0.0627228959319087 no 277 0.0721497116245792 111 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1369 1866-0067 208 µM 1.45862923706513 0.0628967194630149 no 278 0.0723335910205506 101 3531355 SGTC_1612 st002233 45.4 µM 1.45731390582882 0.0630681244801835 no 279 0.0725148750092464 98 1035021 SGTC_1954 st077032 68.9 µM 1.45647569307758 0.0631775443136748 no 280 0.072630582134867 96 698907 SGTC_2492 derrusnin 100 µM 1.45547038765358 0.063308971234145 no 281 0.0727695412071295 108 1715307 Part of coumarin class of compounds. SGTC_2504 purpurogallin 52.29 µM 1.45517781329801 0.0633472604122427 no 282 0.0728100207281939 95 5281571 An antioxidant. SGTC_1525 8-methoxypsoralen 92.5 µM 1.45324710463335 0.0636003842337703 no 283 0.0730775789248579 122 4114 Related to psoralen; DNA damaging agent. SGTC_1554 st069299 38.7 µM 1.45236982148215 0.0637156593863449 no 284 0.0731994014277355 93 24207999 SGTC_1188 1403-0014 4.57 µM 1.45200561858449 0.0637635634278907 no 285 0.0732500214912225 105 9614867 SGTC_1106 tegaserod maleate 11.7 µM 1.44957858756698 0.0640835094796829 no 286 0.0735880353377203 110 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1667 st014849 34.6 µM 1.44747032875921 0.0643624447875 no 287 0.0738826203987601 99 5348460 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.43887387585497 0.0655095832211443 no 288 0.0750931302159938 114 23847180 SGTC_1311 1190-0148 100 µM 1.43816420264733 0.0656049883251856 no 289 0.075193734774442 115 1961333 SGTC_3013 9080133 71.4286 µM 1.43596291898688 0.0659016038964998 no 290 0.0755064465101944 97 17050193 SGTC_1003 4049-0218 100 µM 1.43080789644552 0.0666002919285928 no 291 0.0762426396776936 124 295161 SGTC_291 SEC14.278 35.5 µM 1.43062516376701 0.066625163490556 no 292 0.0762688357866127 101 1068044 SGTC_2664 lyso-paf C-16 73.48 µM 1.42762153857837 0.0670350148998474 no 293 0.0767004103588537 115 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1651 st011928 86.1 µM 1.42621248836947 0.0672279536659161 no 294 0.0769035079517145 103 720198 SGTC_1041 0206-0046 107 µM 1.42169901984654 0.0678488659404888 no 295 0.0775568223983799 111 50494 SGTC_1843 st055809 45.5 µM 1.42129655107849 0.0679044474391855 no 296 0.0776152828798529 100 16413835 SGTC_1133 3473-0247 50 µM 1.41557432740275 0.0686985034546996 no 297 0.0784500861254881 149 711311 SGTC_2741 miltefosine 3.04 µM 1.41484345475989 0.0688004380766892 no 298 0.0785572000098003 71 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.41085431976654 0.069358858196472 no 299 0.0791437869137244 70 6708630 An antioxidant. SGTC_1013 4112-3890 241 µM 1.40891938376445 0.0696309750463424 no 300 0.0794295035920409 118 705171 SGTC_87 0100-0052 35.5 µM 1.40749675137403 0.0698315686087429 no 301 0.0796400699407893 126 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_697 0508-1955 564 µM 1.40445202719811 0.0702623740249378 no 302 0.0800921437430499 97 6243113 SGTC_1817 st052116 64.4 µM 1.40230036250398 0.0705680487981093 no 303 0.0804127861097279 80 4361398 SGTC_1806 st050005 60.3 µM 1.3944193903186 0.0716963871283345 no 304 0.0815954980279489 108 5194765 SGTC_229 benomyl 22.8748 µM 1.38375526479558 0.0732451656359148 no 305 0.0832167025793853 111 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1440 4100-1550 40 µM 1.38298041696858 0.0733586885794129 no 306 0.0833354352921827 109 742806 SGTC_1949 st076024 69.1 µM 1.38238326808929 0.0734462686398945 no 307 0.0834270254119321 116 2921930 SGTC_955 1216-0110 33 µM 1.381951023903 0.0735097130420224 no 308 0.083493369797497 104 3619719 SGTC_53 0973-0023 39.979 µM 1.38125288554089 0.073612273641394 no 309 0.0836006095294912 109 674768 SGTC_2257 7960413 200 µM 1.3800827277145 0.0737844219631628 no 310 0.0837805873520724 126 2974689 YIL048W NEO1 SGTC_899 1083-0020 478 µM 1.37893335869862 0.0739538113145674 no 311 0.08395765089802 117 767123 SGTC_234 nsc-17383 10.7 µM 1.37488484704863 0.074552831725329 no 312 0.0845835738843883 116 408974 SGTC_1770 st043884 66.3 µM 1.3746747068459 0.0745840250170254 no 313 0.0846161580577535 143 670149 SGTC_2874 9043904 71.43 µM 1.37418208645832 0.0746571888221085 no 314 0.0846925802890619 121 4463428 SGTC_3338 9144300 39.5675 µM 1.3735958510712 0.0747443276533428 no 315 0.084783592840389 94 4901274 SGTC_3138 9097216 49.47 µM 1.3714629819895 0.0750620151338861 no 316 0.0851153377980061 118 25237486 SGTC_1759 st043059 70 µM 1.36724785471736 0.0756928787216195 no 317 0.0857738150983347 123 669426 SGTC_3279 9140807 49.47 µM 1.36503823032834 0.0760251951756037 no 318 0.0861205172493999 110 45595718 SGTC_1929 genistein trimethyl ether 50.5 µM 1.36399693431416 0.0761821854404434 no 319 0.0862842652678378 118 136420 SGTC_1068 loratadine 26.9 µM 1.36205012146664 0.0764763570430161 no 320 0.0865910339271256 115 3957 A H1 histamine antagonist. SGTC_1407 3909-7909 12.3 µM 1.36168472193044 0.0765316666379007 no 321 0.0866487024451071 108 4411780 SGTC_1170 0310-0127 64.8 µM 1.35762991317658 0.0771474765498253 no 322 0.0872905731184401 124 774975 SGTC_264 promethazine 12.5 mM 1.35215849626153 0.0779843875733064 no 323 0.0881623087925732 151 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.34922445695131 0.0784360081690064 no 324 0.0886324407363651 113 165521 SGTC_2399 5884133 200 µM 1.34776096380818 0.0786620155425687 no 325 0.088867638490146 120 722445 SGTC_155 k072-0202 43.6 µM 1.34738346857836 0.0787203921559723 no 326 0.0889283810112399 129 5857737 SGTC_116 0155-0182 31.788 µM 1.3470829864561 0.0787668827703715 no 327 0.0889767534906163 111 771486 SGTC_1358 1509-0022 2.48 µM 1.34586500256041 0.0789555424133097 no 328 0.0891730286667287 133 3258434 SGTC_724 3910-0327 137 µM 1.34478242188435 0.0791235159117898 no 329 0.0893477542321903 133 2885483 SGTC_3137 9097352 49.47 µM 1.34161363186154 0.0796167414703244 no 330 0.0898606519430664 132 44120435 SGTC_2102 5377816 72.7585 µM 1.3414125157556 0.0796481237369309 no 331 0.0898932781280833 125 1379702 SGTC_3251 9135047 49.47 µM 1.33992935270891 0.0798798463602972 no 332 0.0901341570823484 91 17682963 SGTC_356 1634-0012 32.5 µM 1.33432091680856 0.0807606931349259 no 333 0.091049352707518 134 735457 SGTC_3071 9117417 49.47 µM 1.33423115814414 0.0807748497946788 no 334 0.0910640555340618 112 45595590 YGL055W OLE1 SGTC_2148 5546263 113.568 µM 1.33401348376537 0.080809188993295 no 335 0.0910997187772376 116 792097 SGTC_2330 7979373 200 µM 1.33168886921803 0.0811765959779233 no 336 0.0914812241868533 122 1863007 SGTC_2902 5787006 60.46 µM 1.32773521337623 0.081804366868541 no 337 0.0921327981190743 123 591003 SGTC_2017 5132927 60.65 µM 1.32680643912045 0.0819523692363197 no 338 0.0922863599484773 103 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1137 ixabepilone 100 µM 1.32303055175926 0.082556143854491 no 339 0.0929126089777886 125 154225 A novel microtubule stabilizer. SGTC_3056 9094900 49.47 µM 1.32149000067888 0.0828034416494754 no 340 0.0931690172269551 107 25236784 SGTC_2948 9070189 9.45 µM 1.3191976353859 0.0831724560127481 no 341 0.093551524310882 105 6473636 YDL196W YDL196W SGTC_2611 pyromycin 23.93 µM 1.31713361652692 0.0835057689425532 no 342 0.093896920299755 118 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1505 k297-0037 20.6 µM 1.31698557553493 0.0835297142154768 no 343 0.0939217298256001 109 4089396 SGTC_2237 6667747 47.222 µM 1.31251845292461 0.084254689679169 no 344 0.0946726320219928 105 729940 YDL015C TSC13 SGTC_1249 0481-0015 10.2 µM 1.30983541183615 0.0846923882951991 no 345 0.0951257603513768 138 4227577 SGTC_125 0133-0007 11.75 µM 1.30779029014236 0.0850271634103489 no 346 0.0954722242506035 122 26541 SGTC_1623 st003709 20.3 µM 1.30105532413597 0.0861366520734241 no 347 0.0966197592066849 117 16192618 SGTC_798 1287-0182 476 µM 1.29888509072996 0.0864964640871435 no 348 0.0969916835045516 120 1649755 SGTC_3255 9139072 49.47 µM 1.29838239850273 0.0865799675742871 no 349 0.0970779822258656 115 17646060 SGTC_141 0443-0274 32.331 µM 1.29721256057809 0.0867745255966494 no 350 0.0972790300577079 106 1627241 SGTC_2229 7354935 190 µM 1.29397806183671 0.0873141615862857 no 351 0.0978364993405309 150 318112 SGTC_443 clozapine 122 µM 1.29347300496099 0.0873986497138584 no 352 0.0979237573751534 111 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1709 st033179 39.1045 µM 1.29151192315431 0.0877272866140971 no 353 0.0982631116877811 115 573381 SGTC_1776 st049249 45.9 µM 1.29050607365328 0.0878962035273624 no 354 0.0984375022014728 142 1822314 SGTC_2925 9010536 32.5 µM 1.2902869964222 0.0879330263181997 no 355 0.0984755150484254 107 2994177 SGTC_2837 9008476 45.46 µM 1.28924368767792 0.0881085448898804 no 356 0.0986566906263607 106 2992805 SGTC_542 3381-0244 89.3 µM 1.2863364096631 0.0885990217492297 no 357 0.0991628404027512 127 1112843 SGTC_829 1635-0120 117 µM 1.28585623370328 0.0886802258969683 no 358 0.0992466202270587 157 285054 SGTC_365 0121-0052 13.6 µM 1.27972714955683 0.0897216096995304 no 359 0.10032055638259 122 3101739 SGTC_1531 st059297 52.4 µM 1.27898274749447 0.0898487065751512 no 360 0.100451565672313 128 7566702 SGTC_1659 st012954 42.1 µM 1.27895527898897 0.0898533990204693 no 361 0.100456402314381 115 24207262 SGTC_815 1582-0027 36.9 µM 1.27680403405623 0.0902214622186029 no 362 0.100835720492354 143 3128206 SGTC_1353 1498-1206 8.11 µM 1.27464041435436 0.0905927710372823 no 363 0.101218272984621 127 6756808 SGTC_2657 nystatin 74.44 µM 1.27381510747766 0.0907347042520922 no 364 0.101364474890023 118 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_687 k029-0044 34.9 µM 1.26826859757477 0.0916928561504035 no 365 0.102351023621885 92 5829338 SGTC_2933 9026794 32.47 µM 1.26639241300414 0.0920186552899536 no 366 0.102686312928442 135 17586027 SGTC_2845 9003024 42.97 µM 1.26588236337461 0.092107373334982 no 367 0.102777600765959 129 2990173 SGTC_3242 9133940 49.47 µM 1.26272366108566 0.0926582089445766 no 368 0.103344253818638 108 17248444 SGTC_275 trichlorophene 5.69 µM 1.2610182603972 0.0929566191163142 no 369 0.103651134112047 113 62616 SGTC_3032 9089427 49.47 µM 1.26060992838956 0.0930281741538263 no 370 0.103724709897403 114 17173707 SGTC_2720 fluspirilene 36.88 µM 1.25933419108434 0.0932519933350697 no 371 0.103954824229166 123 3396 An atypical antipsychotic. SGTC_2225 6654152 15.4 µM 1.25879173458654 0.0933472839988925 no 372 0.10405278328518 144 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2488 5268135 45.7 µM 1.25750772481422 0.0935731263019661 no 373 0.104284921797815 151 1270356 YLR208W SEC13 SGTC_1162 k048-0130 20.1 µM 1.25705982646752 0.0936520012320872 no 374 0.104365986410761 130 6797406 SGTC_3162 9099653 49.47 µM 1.25669534364333 0.0937162229025168 no 375 0.10443198743541 103 25237511 SGTC_2721 ifenprodil 61.44 µM 1.25457838401699 0.0940898729535373 no 376 0.104815927249955 128 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2020 4017018 200 µM 1.25407551775733 0.0941787917721056 no 377 0.104907279021206 125 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2462 5162487 171.77 µM 1.25158278618083 0.0946204818992043 no 378 0.105360965134763 131 2259986 SGTC_1306 1185-0270 9.02 µM 1.2489618521982 0.0950865331366724 no 379 0.105839513463875 140 1548076 SGTC_2935 9038016 29.96 µM 1.24703528066259 0.0954301903290087 no 380 0.10619228076569 135 6463195 SGTC_2665 lovastatin 100 µM 1.24644541041223 0.0955355925543792 no 381 0.10630045934009 137 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1351 1496-0003 46.5 µM 1.24632482843235 0.095557149546101 no 382 0.106322583127581 131 3891978 SGTC_1346 1488-2224 62.4 µM 1.24541441274564 0.0957200242737044 no 383 0.106489729051015 141 3722427 SGTC_3026 9090633 49.47 µM 1.24502777476921 0.0957892561399565 no 384 0.106560770427724 126 25236842 SGTC_292 k038-0015 474 µM 1.2442630641861 0.0959262946089536 no 385 0.106701380105584 132 46368540 SGTC_2406 ethylparaben 405.7 µM 1.24354541498555 0.0960550306318161 no 386 0.106833458213067 117 8434 A possible steroid mimic. SGTC_694 1315-0438 43.2 µM 1.24245866374889 0.0962502200608134 no 387 0.107033691368854 119 6793154 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.23968499036857 0.0967497158368932 no 388 0.107545965477764 144 390807 SGTC_908 3448-7491 47.7 µM 1.2357181160849 0.0974673930752458 no 389 0.108281680597042 127 1203031 SGTC_2068 5226020 147 µM 1.23330299432405 0.0979062390346272 no 390 0.108731370581572 137 1810509 SGTC_1271 0832-2808 169 µM 1.23059344436676 0.0984003065954285 no 391 0.109237479171189 157 3663794 SGTC_967 1306-0166 352 µM 1.22830283924186 0.0988194045832709 no 392 0.109666652780278 151 4437607 SGTC_1723 st034307 2.5525 µM 1.22714821750998 0.0990311531147783 no 393 0.109883443957422 158 867466 SGTC_884 0851-0618 334 µM 1.22696839476328 0.0990641610376387 no 394 0.109917235043741 142 9642473 SGTC_2785 7756463 72.73 µM 1.22634450310651 0.0991787438002003 no 395 0.110034530401543 175 2201551 SGTC_1245 0418-0076 17.2 µM 1.22537402207752 0.0993571730997375 no 396 0.110217165081904 129 6790114 SGTC_2296 7971656 126.45 µM 1.22218409115347 0.0999453160667658 no 397 0.11081900929508 112 666570 SGTC_3187 9109394 49.47 µM 1.21936776002374 0.100466686457493 no 398 0.111352320430515 148 17098090 SGTC_2575 plumbagin 510 nM 1.21520280099772 0.101241353299739 no 399 0.11214437619957 151 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2201 6605497 169.863 µM 1.21128398875629 0.101974203454182 no 400 0.112893291496132 143 670741 SGTC_2430 5571206 200 µM 1.21109804534494 0.102009072086015 no 401 0.112928915227063 150 1731771 SGTC_88 0180-0332 8.668 µM 1.2102728314567 0.102163923209449 no 402 0.113087109598486 151 3101745 SGTC_1496 4469-0713 57.4 µM 1.21013323189674 0.10219013592461 no 403 0.113113886612044 133 746691 SGTC_523 1934-0222 13.7 µM 1.20599958903369 0.102968531776393 no 404 0.1139088244451 151 1361595 SGTC_3150 9097574 49.47 µM 1.20217416002759 0.103692717951033 no 405 0.114648029263566 134 17217476 SGTC_2680 butyl paraben 22.24 µM 1.20123808840424 0.103870485649723 no 406 0.114829429288066 158 7184 An antifungal and steroid mimetic. SGTC_337 1315-0038 354 µM 1.20104507285186 0.103907168362316 no 407 0.114866858882521 113 1626437 SGTC_2022 5136654 200 µM 1.19833885982166 0.10442247530941 no 408 0.115392562045522 163 1713771 SGTC_1374 2889-5571 141 µM 1.19741461115487 0.104598890787719 no 409 0.115572495718747 183 2853281 SGTC_1891 st059073 26.2 µM 1.19543100769809 0.104978238729792 no 410 0.115959338424513 156 688754 SGTC_547 1120-0019 610 nM 1.19511815289566 0.105038160462569 no 411 0.11602043525559 144 3676939 SGTC_3249 9135183 49.47 µM 1.19356210172669 0.10533656198745 no 412 0.116324653066802 141 4902779 SGTC_426 0988-0037 14.6 µM 1.19239969464256 0.105559874838978 no 413 0.116552279989672 168 5383008 SGTC_1359 1582-0056 520 nM 1.19083901790125 0.105860238361503 no 414 0.116858394111324 135 3661189 SGTC_244 nsc-207895 1.295 µM 1.18215974666034 0.10754190042373 no 415 0.11857116064878 93 42640 SGTC_446 go6976 132 µM 1.18192665114325 0.107587328054372 no 416 0.118617403029991 134 3501 A protein kinase C inhibitor. SGTC_190 3970-0790 3.722 µM 1.18040668485745 0.107883891056362 no 417 0.11891925224035 139 2832352 SGTC_2676 harmalol 100 µM 1.17761115212175 0.10843086811098 no 418 0.119475830923155 140 5459187 A monoamine oxidase inhibitor SGTC_2911 7942208 15.64 µM 1.17757413704338 0.108438123882825 no 419 0.119483212775496 124 1243384 SGTC_2600 tangeritin 87.95 µM 1.17698804154811 0.108553058088401 no 420 0.119600139660881 167 68077 A bioactive flavone. SGTC_657 3534-0529 86.7 µM 1.17597567570808 0.108751790908989 no 421 0.119802298149701 152 1049549 SGTC_2469 5655019 90.81 µM 1.17333500949409 0.109271398703913 no 422 0.12033074408849 140 2788239 SGTC_839 0122-0028 230 µM 1.16561992948401 0.110799718294675 no 423 0.121884073227602 197 759448 SGTC_1637 st007924 17.4 µM 1.15743549623297 0.112437691228024 no 424 0.123547239358333 130 683336 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.15202196627762 0.113530577816888 no 425 0.124656023469638 168 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2473 5854593 8.94 µM 1.15196990497144 0.113541124626949 no 426 0.124666720178787 159 2872951 SGTC_1275 0867-0008 21.1 µM 1.15159874331911 0.113616336443697 no 427 0.124742999020221 139 3422836 SGTC_382 3229-0966 23.2 µM 1.15159028379079 0.113618051087752 no 428 0.12474473795012 154 5722370 SGTC_59 0330-0160 1.33 µM 1.15077440244454 0.113783507064707 no 429 0.124912529094475 144 4293482 SGTC_321 4534-3890 65.3 µM 1.14996773622722 0.113947263023766 no 430 0.125078580041393 160 699746 SGTC_2235 salicylic acid 500 µM 1.14886259171293 0.114171883597143 no 431 0.125306322463135 146 338 A COX inhibitor and kinase inhibitor. SGTC_1064 honokiol 6.76 µM 1.14882297005746 0.114179942548624 no 432 0.125314492859507 164 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1754 st042065 16.137 µM 1.14638852401583 0.114675880560804 no 433 0.125817214481297 165 1126236 YIL048W NEO1 SGTC_898 1000-0849 28.3 µM 1.14542553117413 0.114872481046022 no 434 0.12601646362088 176 6751807 SGTC_429 1112-0049 25.5 µM 1.14521360581017 0.114915778987226 no 435 0.126060341801252 141 2836170 SGTC_847 0342-0274 5.54 µM 1.14318126813515 0.115331590324216 no 436 0.126481668949509 172 18097 SGTC_1203 3992-3522 103 µM 1.14152022778415 0.115672228441531 no 437 0.126826749644667 161 5322312 SGTC_1378 2093-0007 380 nM 1.13958459761264 0.116070079002138 no 438 0.12722970260572 164 3618014 SGTC_1685 st024049 53.0905 µM 1.13831980339891 0.116330569682233 no 439 0.127493483850164 150 1941139 SGTC_1183 1254-0324 198 µM 1.13583144547055 0.116844269552498 no 440 0.128013556940443 133 5799357 SGTC_2690 usnic acid 100 µM 1.13498096036214 0.117020212972261 no 441 0.128191647958173 140 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_765 1319-0117 244 µM 1.13478059511384 0.11706169068146 no 442 0.128233629339569 151 3487746 YGL099W LSG1 SGTC_1609 st001574 46.4 µM 1.13091563741913 0.117863816707062 no 443 0.129045300457639 174 3960012 SGTC_2513 baicalein 25.65 µM 1.13066048110739 0.117916907877491 no 444 0.129099010338979 161 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2598 perillyl alcohol 100 µM 1.12978137721942 0.118099955326997 no 445 0.129284178590767 137 10819 An apoptosis inducer. SGTC_1590 st077108 57.8 µM 1.12800278641871 0.118470908782775 no 446 0.129659371186035 140 5489485 SGTC_3295 9122362 53.5725 µM 1.12783844552734 0.118505226210555 no 447 0.129694076814784 178 4730473 SGTC_2336 9001819 198.65 µM 1.12783548002594 0.118505845526801 no 448 0.129694703130611 204 2989602 SGTC_503 tyrphostin 8 294 µM 1.12683431436992 0.118715060035772 no 449 0.129906269710831 171 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1923 st058458 19.1 µM 1.1244346394791 0.119217584207591 no 450 0.130414341923323 189 3534982 SGTC_1080 nisoldipine 24.4 µM 1.12422503700345 0.119261548977172 no 451 0.130458785277499 167 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2212 7123476 200 µM 1.12394321490998 0.119320680070254 no 452 0.130518558328317 134 1085715 SGTC_123 0083-0120 66.675 µM 1.12273101289777 0.119575256656478 no 453 0.130775876200298 183 16001701 SGTC_1621 st003705 32.4 µM 1.12270826718933 0.1195800371802 no 454 0.130780707851434 154 24207032 SGTC_1737 st035557 69.7 µM 1.11557743011853 0.121085394874291 no 455 0.132301528778475 162 5716916 SGTC_1937 st074714 47.2 µM 1.11344803864895 0.121537494594553 no 456 0.132758026504109 136 17250970 SGTC_2327 6189656 200 µM 1.11292441364983 0.12164884906152 no 457 0.132870446909102 154 5349088 SGTC_2348 9022543 33.42 µM 1.11088305594419 0.122083650194001 no 458 0.133309344872986 187 3162678 YDL140C RPO21 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.11003682998063 0.122264212562098 no 459 0.133491578085025 160 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2896 9052656 71.43 µM 1.10991755181376 0.122289678452838 no 460 0.133517278190264 192 6469436 SGTC_1336 1486-0901 104 µM 1.10906210732245 0.122472424974351 no 461 0.133701695068891 152 5006114 SGTC_546 peri-Naphthalide 147 µM 1.10559741426149 0.123214538421274 no 462 0.134450404754228 178 223824 A penicillin ester. SGTC_1459 k035-0031 35.7 µM 1.10501939059742 0.123338653193924 no 463 0.134575593547841 150 3877128 YMR208W ERG12 SGTC_583 1488-1091 88.9 µM 1.09954638838489 0.124518172753319 no 464 0.135764905879286 195 4303273 SGTC_2091 4-phenylthiadiazole 200 µM 1.09876868345316 0.124686418410106 no 465 0.135934487612893 147 270010 SGTC_3321 9137793 26.8275 µM 1.09870029389414 0.124701221137711 no 466 0.135949407169788 175 4904192 SGTC_2848 9016370 25.97 µM 1.09676849364652 0.125119861287419 no 467 0.136371303118656 147 7894410 SGTC_3011 9081274 71.4286 µM 1.09645443294625 0.12518801398303 no 468 0.136439977031203 155 6625322 SGTC_3246 9135460 32.98 µM 1.09566861566398 0.125358653707108 no 469 0.136611910972283 162 41446951 SGTC_737 1950-0117 57.9 µM 1.09119654331727 0.126332852530743 no 470 0.137593204295578 162 5393513 SGTC_1875 nocodazole 6 µM 1.09087229065597 0.126403692480059 no 471 0.137664540676512 166 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2711 st079103 59.1 µM 1.08884379662972 0.126847488663318 no 472 0.138111387187187 149 54693780 SGTC_2379 9035213 200 µM 1.08830779889054 0.126964935811821 no 473 0.138229624387439 178 646551 SGTC_3078 9116413 49.47 µM 1.08771856412839 0.127094135505029 no 474 0.138359684898208 173 17177322 SGTC_1925 st057770 10.1 µM 1.0861765709963 0.127432676486368 no 475 0.13870044035267 152 5989122 SGTC_1212 0520-0165 585 µM 1.08582044418536 0.127510952356287 no 476 0.138779219786157 164 5403258 SGTC_2459 5811157 9.22 µM 1.08492910013826 0.12770701430665 no 477 0.138976529128631 162 2870684 YBR192W RIM2 SGTC_60 0986-0278 202 µM 1.07954813256065 0.128895074149653 no 478 0.140171724505336 159 3110598 SGTC_704 1310-0270 142 µM 1.07933579607303 0.12894211246936 no 479 0.140219030461566 169 5718033 SGTC_1192 1488-0095 21.4 µM 1.07694812021322 0.129471867427307 no 480 0.140751721820545 154 915875 SGTC_1001 4048-4355 44.4 µM 1.07472620020439 0.129966198929063 no 481 0.14124866498954 181 21824233 SGTC_1973 st070275 50.2 µM 1.07217515830724 0.130535362586885 no 482 0.141820682995319 135 17118334 SGTC_2776 terbinafine 19.92 µM 1.0645114674471 0.132255567936748 no 483 0.14354853116001 160 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_394 menadione 8.33 µM 1.06192586643928 0.1328394461626 no 484 0.144134670647416 184 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1366 1683-0113 21.9 µM 1.05976042180925 0.133329808896489 no 485 0.144626803346774 160 708623 SGTC_1027 k015-0025 8.67 µM 1.05749271245389 0.133844662780963 no 486 0.145143389406055 172 3598955 SGTC_1766 st045414 44.774 µM 1.05122914595664 0.135273817088129 no 487 0.146576680000426 165 253960 SGTC_102 gallobenzophenone 83.616 µM 1.04894380725604 0.135797856802094 no 488 0.147101990862261 168 70837 SGTC_2859 9028643 45.46 µM 1.04640452170415 0.136381756479098 no 489 0.14768715299407 144 17151580 SGTC_199 4063-0024 41.6 µM 1.04628807811326 0.136408573392774 no 490 0.14771402400741 137 306215 SGTC_2592 piperlongumine 83.33 µM 1.04605700541507 0.136461800026077 no 491 0.147767357011071 183 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1734 st037168 69.4 µM 1.04514202096344 0.136672702370232 no 492 0.147978667670754 168 708907 SGTC_63 0099-0242 26.702 µM 1.04226204891337 0.137337985176851 no 493 0.148645101195639 197 3898502 YLR359W ADE13 SGTC_2589 lobaric acid 100 µM 1.0404171341817 0.137765326659528 no 494 0.149073072328111 150 73157 A novel microtubule depolymerizer. SGTC_1433 4060-0023 7.6 µM 1.03827302514701 0.13826311003254 no 495 0.149571481695134 189 3840627 SGTC_1315 1237-0019 3.69 µM 1.03551222285297 0.138905870814414 no 496 0.150214880615328 162 825140 SGTC_2384 9036245 200 µM 1.03432780056886 0.139182246754832 no 497 0.150491472247512 144 6462766 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.03414720453645 0.139224420325194 no 498 0.150533675636807 209 2346 DNA damaging agent; causes G2/M arrest. SGTC_1951 sophoraflavanone G 9.2 µM 1.03386043045901 0.139291406920665 no 499 0.150600707913085 165 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2277 7947813 106.88 µM 1.03154277121545 0.139833585943777 no 500 0.151143180846624 165 1246798 SGTC_362 0310-0100 9.03 µM 1.03146041023266 0.139852879326019 no 501 0.151162482205778 158 790235 SGTC_1256 0570-0116 285 µM 1.03009073223213 0.140173997005863 no 502 0.151483707679738 180 410638 SGTC_1105 epirubicin 18.1 µM 1.02984918567433 0.140230678920641 no 503 0.151540403735735 176 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.02944788381903 0.140324883823652 no 504 0.151634628903078 183 688664 SGTC_750 4073-0104 132 µM 1.02872415186148 0.140494887248598 no 505 0.151804658675138 138 22330957 SGTC_2412 st077135 33.4 µM 1.02836572969404 0.140579131764353 no 506 0.151888911377969 182 13258915 SGTC_936 3005-4620 401 µM 1.02646995048987 0.141025291085712 no 507 0.152335060383163 177 777207 SGTC_250 brefeldin a 552.239 µM 1.02580400001204 0.141182245885083 no 508 0.152491990129862 157 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1479 0549-0158 134 µM 1.02502828840214 0.141365219055239 no 509 0.15267492005341 174 5440202 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.02301341879334 0.141841232780424 no 510 0.153150750641132 185 551469 SGTC_289 k017-0060 526 µM 1.02033848788292 0.142474861509882 no 511 0.153783977936537 184 5512909 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.01911303113317 0.14276578210383 no 512 0.154074654175643 207 5393153 SGTC_2476 5806916 10.51 µM 1.01842130073121 0.14293017448757 no 513 0.154238891829133 173 2870194 SGTC_151 3013-0144 2.285 µM 1.01776914759374 0.143085278293343 no 514 0.154393838644672 207 906558 YHR107C CDC12 SGTC_2540 epiandrosterone 100 µM 1.01767296681337 0.143108162914788 no 515 0.154416699199782 197 441302 A steroid. SGTC_2397 5161689 200 µM 1.01192324799351 0.144480706152823 no 516 0.155787376313305 177 2259942 SGTC_2185 6113692 200 µM 1.01180976903791 0.144507884225424 no 517 0.155814509076123 181 874150 SGTC_127 0180-0333 59.125 µM 1.00897215951187 0.145188608340211 no 518 0.156493993142306 147 771601 SGTC_341 1486-1430 230 µM 1.00720801587101 0.145612900997992 no 519 0.15691741090857 216 2054753 YPL210C SRP72 SGTC_2775 cyproheptadine 69.59 µM 1.00509368148039 0.146122515061216 no 520 0.157425871156347 178 2913 A selective serotonin reuptake inhibitor. SGTC_965 1291-5240 308 µM 1.00493453947088 0.146160921184217 no 521 0.157464185783407 189 2834598 SGTC_779 1360-0071 233 µM 1.00425180975825 0.146325762916499 no 522 0.157628627596764 190 7566 SGTC_3280 9140961 49.47 µM 1.00288311792796 0.146656602675963 no 523 0.157958629471136 194 4901226 SGTC_3126 9127922 49.47 µM 1.00196035817028 0.146879934945585 no 524 0.15818136959163 224 45595682 SGTC_3289 9119912 71.43 µM 1.00173671526329 0.146934096770951 no 525 0.158235384594349 183 17014829 SGTC_1656 st012921 11 µM 0.998674871022313 0.147676961052347 no 526 0.158976108796488 170 6732821 SGTC_505 gw-5074 63.9 µM 0.998444632866806 0.147732922912381 no 527 0.159031899927237 190 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_299 1273-0059 1.44 µM 0.998171716200482 0.147799276635431 no 528 0.159098049495119 190 2848077 SGTC_527 4476-4215 268 µM 0.997996056082921 0.147841995108057 no 529 0.159140635544599 157 4418754 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.997967528706998 0.147848933410236 no 530 0.159147552265664 169 115019 SGTC_934 2950-0684 338 µM 0.992593835106338 0.149159788330793 no 531 0.160453965157719 194 1121253 SGTC_1472 k841-0093 193 µM 0.991478828232769 0.149432751700157 no 532 0.160725912722945 189 X1472 SGTC_1696 st025591 34.7925 µM 0.990178916156851 0.149751402175874 no 533 0.161043338000953 166 2787147 SGTC_2710 st078562 53.7235 µM 0.986630160354825 0.150623623319489 no 534 0.16191198952063 191 17250908 SGTC_2566 crystal violet carbinol 226 nM 0.986326918447894 0.150698311382734 no 535 0.161986357270029 226 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2914 7968218 45.32 µM 0.986190463560673 0.150731928077105 no 536 0.162019829041047 143 2977111 SGTC_2120 5538279 151.968 µM 0.984276092972754 0.151204074148405 no 537 0.162489890443125 155 2058197 SGTC_1339 1486-1321 22.7 µM 0.983124141200507 0.151488656557061 no 538 0.162773172050188 183 3469382 SGTC_2312 7706453 155.7 µM 0.982147245353098 0.151730271381066 no 539 0.163013656409754 182 976098 SGTC_293 4049-0273 38.5 µM 0.981160408439945 0.151974604800811 no 540 0.163256822361262 186 1380311 SGTC_842 0271-0008 11.1 µM 0.978071576976425 0.152741064731994 no 541 0.164019462160845 188 1221709 SGTC_90 0870-0863 4.608 µM 0.976019663473858 0.153251639635412 no 542 0.164527360058998 216 1738164 SGTC_1689 st020265 53.493 µM 0.973895955031352 0.153781268788512 no 543 0.165054101180556 182 5758320 YPR016C TIF6 SGTC_3016 9080866 49.47 µM 0.97226635204716 0.154188494145675 no 544 0.165459029349759 187 17066299 SGTC_3119 9125183 49.47 µM 0.972129987204451 0.154222602989716 no 545 0.165492942769107 149 22695334 SGTC_3332 9141069 11.198 µM 0.971495430500727 0.154381389856621 no 546 0.165650813753667 184 17332883 SGTC_2298 7976326 193.81 µM 0.970701494527138 0.154580210808309 no 547 0.165848473712277 149 2235818 SGTC_1325 1431-0015 227 µM 0.969394861493909 0.154907791900229 no 548 0.166174107575965 167 1103340 SGTC_2923 7992654 58.14 µM 0.966343509908864 0.155674569255753 no 549 0.166936160476104 187 2985126 SGTC_236 1509-0011 5.31 µM 0.96583198429606 0.155803355634325 no 550 0.167064130539464 229 3107280 SGTC_1898 st060199 18.6 µM 0.96489914388187 0.156038396905122 no 551 0.167297665144717 175 688866 SGTC_3305 9127027 53.8275 µM 0.963190122327206 0.156469613028753 no 552 0.167726060598473 205 41905295 SGTC_1579 chlormadinone acetate 49.4 µM 0.960575709017671 0.157130792351273 no 553 0.168382773585552 192 45114258 A steroidal progestin. SGTC_1086 cerivastatin 2.18 µM 0.959204239506217 0.157478367613436 no 554 0.168727932578276 187 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2830 7992007 71.43 µM 0.957133337948061 0.158004158637291 no 555 0.16924997928747 198 1952075 SGTC_2920 7982904 15.77 µM 0.955541914344069 0.158408994981229 no 556 0.169651859824643 194 6456808 SGTC_477 mead ethanolamide 10 µM 0.9553683602438 0.158453185877858 no 557 0.169695724247353 134 16061185 SGTC_1010 4112-3296 15.2 µM 0.955253082259719 0.158482542793454 no 558 0.169724863863969 177 704384 SGTC_730 1436-0052 41.2 µM 0.955237989792238 0.158486386534658 no 559 0.169728679129358 170 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1844 rapamycin 4 nM 0.954640960994647 0.158638486546256 no 560 0.169879647766478 211 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2819 7996655 46.38 µM 0.952835777767689 0.159098959937101 no 561 0.170336641826161 169 6456960 SGTC_1097 itavastatin 7.23 µM 0.951614202149178 0.15941106060969 no 562 0.170646338095327 204 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1026 k007-1105 30.6 µM 0.951413312633385 0.159462424277757 no 563 0.170697302494607 206 7066794 SGTC_1911 st060208 74.3 µM 0.94957051642822 0.1599340980499 no 564 0.171165262758977 205 688783 SGTC_1073 triclabendazole 3.09 µM 0.949061351429033 0.160064582343818 no 565 0.171294704800089 195 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1567 st069303 68.4 µM 0.948431591793624 0.16022606782631 no 566 0.171454891457955 205 5581319 SGTC_2970 9090938 41.86 µM 0.946849358060392 0.160632260247351 no 567 0.171857773211801 205 17217104 SGTC_1108 betulinic acid 729.144 nM 0.942749729419142 0.161687846613813 no 568 0.172904465193184 178 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2844 9010103 25.97 µM 0.942014600634035 0.161877607050456 no 569 0.173092582378255 205 2480525 SGTC_117 lucigenin 22.078 µM 0.940816623087489 0.162187154439332 no 570 0.173399420346928 198 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2391 6285546 200 µM 0.940382234765437 0.162299491903947 no 571 0.173510765705362 184 846083 SGTC_614 0462-0418 107 µM 0.938860970437631 0.162693306335374 no 572 0.173901065106634 188 5188303 SGTC_1230 0170-0365 3.77 µM 0.937206785795049 0.16312223508053 no 573 0.174326099961995 202 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2341 7987486 176.74 µM 0.93708147861216 0.163154757050793 no 574 0.174358323916034 186 1258686 SGTC_3039 9090270 49.47 µM 0.936701744477011 0.163253338203994 no 575 0.174455999330445 174 17173750 SGTC_1397 3532-0190 20.1 µM 0.935491992745382 0.163567654661391 no 576 0.174767403990022 165 5322280 SGTC_725 1497-0963 19 µM 0.93021865876635 0.164942353300321 no 577 0.17612894149988 206 3549977 SGTC_100 0086-0128 49.5915 µM 0.929552065541115 0.165116657754016 no 578 0.176301527915918 214 93297 SGTC_3277 9138724 49.47 µM 0.927637454982278 0.165617963448413 no 579 0.176797831025832 159 15943418 SGTC_3240 9133527 49.47 µM 0.927184873130839 0.165736607394593 no 580 0.176915277696738 196 17617455 SGTC_1226 3909-7979 35.4 µM 0.927085601096523 0.165762638820473 no 581 0.176941045750437 218 6615510 SGTC_2053 5265679 138 µM 0.926487631341679 0.165919496246425 no 582 0.177096310997258 232 764595 SGTC_2056 5235370 200 µM 0.926423046985291 0.165936443536997 no 583 0.177113085733162 188 5511916 SGTC_2846 9008642 19.48 µM 0.923891833180851 0.166601529018015 no 584 0.177771317774212 217 2992898 SGTC_2207 7258803 200 µM 0.922317407845747 0.167016081592599 no 585 0.178181518247483 211 3666799 SGTC_2308 7584454 197.62 µM 0.919216320567249 0.167834554140784 no 586 0.17899121812764 201 893577 SGTC_462 ag-879 158 µM 0.918350812292367 0.168063448624791 no 587 0.1792176166402 227 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3112 9123419 49.47 µM 0.917638642333988 0.168251941455512 no 588 0.179404040126224 228 17015854 SGTC_418 lividomycin a 100 µM 0.916986391800575 0.168424694438788 no 589 0.179574885530465 196 72394 An antibiotic. SGTC_3 0833-0587 95.581 µM 0.916125232387228 0.168652953002568 no 590 0.179800607455136 199 5382644 SGTC_1284 0929-0043 16 µM 0.913781854439182 0.169275093986385 no 591 0.180415741480312 208 1239883 SGTC_1963 st076565 50.3 µM 0.913198025911675 0.169430322975812 no 592 0.180569201005312 220 4914280 SGTC_2142 5622915 118.518 µM 0.911737352590596 0.169819088487636 no 593 0.180953497969197 193 5322196 SGTC_464 bw-b 70c 158 µM 0.911219137737887 0.169957151321469 no 594 0.181089961185276 212 5353454 SGTC_1279 0874-0590 65.2 µM 0.908157121779937 0.170774401955426 no 595 0.181897607263467 208 3523074 SGTC_971 1315-0384 26.7 µM 0.905992567713035 0.171353635213846 no 596 0.182469893162914 202 6769120 SGTC_1261 0712-0010 12.7 µM 0.905021689349595 0.171613849135857 no 597 0.182726948420253 209 2840123 SGTC_1767 st044992 70.3 µM 0.903608292387539 0.171993117526032 no 598 0.183101571323672 220 9600693 SGTC_193 1273-0060 1.558 µM 0.903450950762499 0.172035371368931 no 599 0.183143304565406 204 2847393 YHR072W ERG7 SGTC_2585 alliin 100 µM 0.901157022479719 0.172652154576723 no 600 0.183752419037985 204 87310 A garlic compound which reacts with lipids. SGTC_450 aminopyrene 156 nM 0.900703738249311 0.172774198624821 no 601 0.183872930281887 214 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_173 1273-0061 2.693 µM 0.900642442346988 0.172790706396854 no 602 0.18388923033642 214 2847414 YPL266W DIM1 SGTC_279 1273-0055 2.93 µM 0.899222440346539 0.17317341250911 no 603 0.184267094891189 230 2847562 SGTC_2339 9000433 200 µM 0.894938826431251 0.17433116088929 no 604 0.185409895029222 213 2988954 SGTC_1166 k206-0078 225 µM 0.893337993654059 0.174765083352741 no 605 0.18583809870304 202 5404595 SGTC_343 4130-2827 29.8 µM 0.8928250044993 0.174904279357629 no 606 0.185975446845279 188 1118244 SGTC_530 4358-1714 28 µM 0.8868523213782 0.176530100324036 no 607 0.187579207041685 218 1564641 SGTC_1822 st052468 42 µM 0.886599268086015 0.176599194241938 no 608 0.187647344032966 214 2873678 SGTC_2189 6047310 154.431 µM 0.885820145332997 0.17681203404665 no 609 0.187857226197167 205 711535 SGTC_1747 st037496 66.6 µM 0.884820244474308 0.177085423214015 no 610 0.188126794463813 229 723305 SGTC_1067 clotrimazole 1.36 µM 0.884755627315193 0.177103099778671 no 611 0.188144223134965 210 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1959 st077091 55.8 µM 0.884551992370821 0.177158813112991 no 612 0.188199154482956 225 821356 YKL052C ASK1 SGTC_1837 st055472 66.5 µM 0.884094912546118 0.177283907797293 no 613 0.18832248964292 203 676091 SGTC_1406 3909-7906 11.9 µM 0.883007877011973 0.177581634252415 no 614 0.188616007799336 207 X1406 SGTC_1711 st032263 62.8 µM 0.882174763970832 0.177810027736368 no 615 0.188841153348336 226 3958979 SGTC_2861 9024595 19.48 µM 0.881219911920059 0.178072023094131 no 616 0.18909940196936 182 16482810 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.881089545920629 0.178107812206998 no 617 0.189134677534318 227 688801 SGTC_2557 derrustone 83.84 µM 0.880174430826204 0.178359164510829 no 618 0.189382411376565 223 629853 An antioxidant. SGTC_1318 1280-3875 124 µM 0.879425939764971 0.17856491669772 no 619 0.189585186285335 239 373245 SGTC_2654 protoveratrine a 100 µM 0.879409507037974 0.178569435554929 no 620 0.189589639599591 239 5702278 A heart drug and vasodilator. SGTC_978 1416-0512 87.4 µM 0.879253331467831 0.178612386075221 no 621 0.189631966821294 207 6814003 SGTC_662 k832-1615 104 µM 0.87813464205358 0.178920231871006 no 622 0.18993532766704 214 5878478 SGTC_2827 7993847 71.43 µM 0.874954472400404 0.179797187203301 no 623 0.190799339110253 190 2985692 SGTC_368 fentichlor 4.58 µM 0.872327753442767 0.180523556924755 no 624 0.191514800620506 220 7329 A pesticide. SGTC_862 0452-0056 10.2 µM 0.871625951976745 0.180717938067838 no 625 0.191706234064667 206 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_467 ro 31-8220 72.8 µM 0.87048147480705 0.181035210486137 no 626 0.192018669349493 219 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_912 3474-0017 2.18 µM 0.868949936401477 0.181460329805819 no 627 0.192437257181698 211 3360550 SGTC_813 k007-0158 173 µM 0.86814720730638 0.181683398072817 no 628 0.192656875350122 214 6523916 SGTC_1163 k060-0048 49.9 µM 0.867061502479798 0.181985374551479 no 629 0.192954156243608 205 6809982 SGTC_1089 terbinafine 2.25 µM 0.865870051611076 0.18231712405467 no 630 0.193280714069534 214 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2369 9071472 200 µM 0.863892563633488 0.182868572477674 no 631 0.193823456144825 214 17296037 SGTC_383 2324-0395 7.37 µM 0.862976953472984 0.183124254585435 no 632 0.194075069184851 210 3146421 SGTC_440 fluspirilene 35.1 µM 0.861499773028959 0.183537223786432 no 633 0.19448142305864 216 3396 An atypical antipsychotic. SGTC_3047 9092122 49.47 µM 0.8611200825217 0.183643465983077 no 634 0.19458595477547 206 17173831 SGTC_590 k048-0076 22.4 µM 0.859881479365028 0.183990309106863 no 635 0.19492718936626 221 6832814 SGTC_1265 0819-1001 68.8 µM 0.856089160731148 0.185054797134524 no 636 0.19597423185529 231 3106768 SGTC_1498 4478-3555 97.6 µM 0.855591950091793 0.185194645239488 no 637 0.196111762077912 206 3437919 SGTC_2930 9013230 14.89 µM 0.852150919879651 0.186164285717125 no 638 0.197065166618428 218 2995857 SGTC_3317 9138495 8.753 µM 0.851996405812114 0.186207899591754 no 639 0.197108043459597 230 17020139 SGTC_3193 9111931 49.47 µM 0.849040038168648 0.187043597188841 no 640 0.197929506864141 248 17087244 SGTC_2797 7859098 81.82 µM 0.848626912090999 0.187160562979542 no 641 0.198044463519764 229 972681 SGTC_502 l-744,832 89.3 µM 0.847432889246836 0.187498873392042 no 642 0.198376939467596 226 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_3086 9117350 49.47 µM 0.847220656805586 0.187559046150591 no 643 0.198436070876167 200 2679265 SGTC_1499 4480-0877 67.3 µM 0.845265759106323 0.188113865439303 no 644 0.198981237119286 210 2861909 SGTC_2291 7917025 104.35 µM 0.845254362127843 0.188117102981461 no 645 0.198984418061531 209 2964612 SGTC_19 0279-0214 38.434 µM 0.843071793918884 0.188737739367016 no 646 0.199594146270313 238 3566274 YBR002C RER2 SGTC_2871 9038510 12.99 µM 0.84267908775255 0.188849543344286 no 647 0.199703972965426 250 4945164 SGTC_796 1234-0020 70.7 µM 0.842497998983318 0.188901113307947 no 648 0.199754629644463 224 46495034 SGTC_3057 9095946 49.47 µM 0.841145904462397 0.189286433271625 no 649 0.200133100667086 252 24540043 SGTC_814 3342-0569 96 µM 0.840671534261327 0.189421733893009 no 650 0.200265985888492 226 4346283 SGTC_3303 9125618 40.5795 µM 0.839389901263841 0.18978758082641 no 651 0.200625274488882 217 22695467 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.838780374096863 0.189961724999307 no 652 0.200796282952235 224 5106787 A p450 inhibitor. SGTC_3083 9117465 49.47 µM 0.838035115198642 0.19017478165464 no 653 0.201005491033157 234 16420915 SGTC_1109 tnp00067 928.257 nM 0.837724778449824 0.190263544857577 no 654 0.201092646897276 214 676295 SGTC_2888 9058547 12.99 µM 0.834334725726638 0.191234831999905 no 655 0.202046194361038 194 16476514 SGTC_2101 5377231 179.231 µM 0.831174459804075 0.192143014912088 no 656 0.202937540369321 228 2844213 SGTC_1523 st012844 44.7 µM 0.828530963885685 0.192904713953889 no 657 0.20368493336552 189 4274103 SGTC_2519 cryptotanshinone 88.04 µM 0.82850850441189 0.19291119333596 no 658 0.203691290333382 222 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_992 3909-8734 162 µM 0.828345833017141 0.192958126725613 no 659 0.203737336654118 217 4288319 SGTC_3153 9100258 49.47 µM 0.827850267963821 0.193101148420826 no 660 0.203877651234745 223 25236848 SGTC_1618 st003135 44.5 µM 0.827761001892027 0.193126917778486 no 661 0.20390293220282 245 1270615 SGTC_526 4469-0568 170 µM 0.827532332516332 0.193192939702465 no 662 0.203967701983645 210 2901964 SGTC_2977 9011197 71.43 µM 0.826578646620906 0.193468438501304 no 663 0.204237962246326 236 2704722 SGTC_1326 1431-2094 10.8 µM 0.826569328013187 0.193471131623123 no 664 0.204240604051389 236 616278 SGTC_2724 maprotiline 69.64 µM 0.826334312986934 0.193539059641267 no 665 0.20430723702897 234 4011 A tricyclic antidepressant. SGTC_1193 1488-0126 41.5 µM 0.825416798358283 0.193804394465599 no 666 0.204567500576703 227 1384710 SGTC_3291 9121177 71.43 µM 0.824793007525664 0.19398491426221 no 667 0.204744558604451 221 17015612 SGTC_1340 1486-1359 257 µM 0.823123029778708 0.194468695786486 no 668 0.205219016842379 236 4309068 SGTC_1500 4488-1866 171 µM 0.822285770126526 0.19471152052981 no 669 0.205457136767195 246 2900003 SGTC_428 3448-4153 16.5 µM 0.820097191984408 0.195347129749637 no 670 0.206080351440456 225 3834874 SGTC_3063 1327-0034 4 µM 0.819300366794407 0.19557885723425 no 671 0.206307531685487 244 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2335 9018011 154.17 µM 0.818865196813535 0.195705480956955 no 672 0.206431664226992 218 6458208 SGTC_2768 sulfasalazine 50.2 µM 0.818350386069692 0.195855342417949 no 673 0.206578571479228 237 5384001 An antioxidant and salicylic acid derivative. SGTC_807 1315-0151 48 µM 0.815908998153535 0.196566978384781 no 674 0.207276092668468 262 4011080 SGTC_1840 st055363 71 µM 0.815123641437629 0.196796233284034 no 675 0.207500770171463 240 676033 SGTC_2140 5586273 200 µM 0.814633693262607 0.196939336920693 no 676 0.207641009080656 215 854421 SGTC_3033 9090887 49.47 µM 0.810267659179174 0.198217344229172 no 677 0.208893179286774 229 19325384 SGTC_648 0375-0473 33.3 µM 0.809790191906432 0.19835740949934 no 678 0.209030385315054 241 1713139 SGTC_3021 9087658 49.47 µM 0.809579290372576 0.198419296585489 no 679 0.209091007331605 216 25237042 SGTC_468 gf-109203x 121 µM 0.807283433653468 0.199093747743412 no 680 0.209751603100562 203 2396 A protein kinase C inhibitor. SGTC_2178 5812956 200 µM 0.803776756771626 0.200126562043973 no 681 0.210762957833124 239 5403383 SGTC_1575 cyproterone acetate 48 µM 0.803242625613222 0.20028416073182 no 682 0.210917256323319 243 9880 An androgen receptor antagonist and liver toxin. SGTC_2951 9072950 58.06 µM 0.800368675993871 0.201133416565367 no 683 0.211748612013318 248 16488155 SGTC_1160 4092-0570 10.5 µM 0.799146245254568 0.201495300100887 no 684 0.21210280857259 238 4994975 SGTC_512 prima-1 270 µM 0.799133463757253 0.201499085944373 no 685 0.212106513811783 214 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2370 9071495 200 µM 0.798325531389636 0.201738479724738 no 686 0.212340802813498 241 21791103 SGTC_3315 9136395 68.55 µM 0.796848257663166 0.202176642391254 no 687 0.212769582226504 269 16876844 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.795994744410197 0.202430055621649 no 688 0.21301754507288 225 641818 YHR062C RPP1 SGTC_1831 st055328 12 µM 0.795058605980281 0.202708219050335 no 689 0.213289705981901 234 1103068 SGTC_2415 st077333 57.7 µM 0.794931028313398 0.202746145053817 no 690 0.213326811972122 259 2766255 SGTC_2104 5389443 200 µM 0.792754872065056 0.203393720666609 no 691 0.213960326853201 232 2244536 SGTC_1872 amphotericin b 148 nM 0.792302839009201 0.203528390262653 no 692 0.214092058355793 232 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3090 9117696 49.47 µM 0.790190224185913 0.204158484805146 no 693 0.214708342156178 224 7923821 SGTC_2311 7694451 200 µM 0.789954648774492 0.204228817899094 no 694 0.214777127130117 259 2163142 SGTC_2553 4-methylesculetin 85.09 µM 0.788635527672133 0.20462291954304 no 695 0.215162529934915 230 5319502 SGTC_2738 aclarubicin 5.55 µM 0.788163239238966 0.2047641307284 no 696 0.21530061426078 202 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_491 tetrandrine 80.3 µM 0.787375062489483 0.204999919509934 no 697 0.21553117024291 240 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3308 9128332 17.569 µM 0.787030481451575 0.205103054107713 no 698 0.215632011408293 222 17332805 YDL196W YDL196W SGTC_1712 st032288 53.4 µM 0.786307876565493 0.205319432992829 no 699 0.215843569545347 248 2883011 SGTC_2954 9074818 52.69 µM 0.785345864337845 0.205607711031932 no 700 0.21612540592206 249 16648742 SGTC_1113 artemisinin 1.17947 µM 0.782306450275696 0.206520083846192 no 701 0.217017248494791 262 2240 An anti-malaria and mitochondrial poison. SGTC_2627 acetyl isogambogic acid 100 µM 0.782254617432562 0.206535663824305 no 702 0.217032476010504 243 6857789 A caspase activator and apoptosis inducer. SGTC_1017 4239-0030 168 µM 0.782000884315718 0.206611941274097 no 703 0.217107026943036 239 1149593 SGTC_3270 9137563 49.47 µM 0.781178707524847 0.206859219302576 no 704 0.217348697532248 226 17015724 SGTC_1456 k015-0012 13 µM 0.779288493643294 0.207428384234127 no 705 0.217904895584164 251 2989616 SGTC_1117 retinoic acid 1.10837 µM 0.778680394906362 0.207611686319523 no 706 0.218084003829134 243 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2682 pyrogallin 40.03 µM 0.776438616955926 0.208288262393294 no 707 0.218745025450403 239 822798 An ATP competetive kinase inhibitor. SGTC_2988 9073640 71.4286 µM 0.773619595876243 0.209140896050156 no 708 0.219577890184943 247 9102229 SGTC_2130 NSC 7 2.4545 µM 0.772819995529484 0.20938311465578 no 709 0.219814458982914 232 21448 SGTC_665 3914-0008 307 µM 0.772042971570289 0.209618652395426 no 710 0.220044488455793 246 1069549 SGTC_2351 9026858 72.31 µM 0.771696360201455 0.20972377025562 no 711 0.220147143496906 262 1409300 SGTC_589 1227-0070 34.1 µM 0.766681734399584 0.211248035527233 no 712 0.221635383099279 239 2841384 SGTC_1721 st082152 9.2685 µM 0.76660515839702 0.211271362070863 no 713 0.221658153787965 251 5296051 SGTC_3028 9087778 49.47 µM 0.765875001395453 0.211493857913619 no 714 0.221875340869554 240 17217395 SGTC_1191 1487-1166 10.6 µM 0.764416657039806 0.21193865986254 no 715 0.222309492750219 262 3955771 SGTC_3352 9151559 45.5865 µM 0.761306436140656 0.212889117875465 no 716 0.223237028613164 231 17159339 SGTC_658 3253-0951 102 µM 0.759841634706001 0.21333760949622 no 717 0.223674626302249 240 1184878 SGTC_919 tnp00227 403.569 nM 0.757082177187809 0.21418399243922 no 718 0.224500315549426 254 1269246 A methoxyflavone. YNL221C POP1 SGTC_3304 9125678 46.087 µM 0.757017776578051 0.214203768746133 no 719 0.224519606232448 244 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2286 7945697 125 µM 0.755602735952065 0.214638571161489 no 720 0.224943707535857 243 1245733 SGTC_2162 5663267 200 µM 0.755507170484327 0.214667954237215 no 721 0.224972365785909 258 6456493 SGTC_672 1441-0018 53.7 µM 0.755388117368281 0.214704562222268 no 722 0.225008070425542 242 251141 SGTC_1679 SEC14.276 6.7 µM 0.753264364624621 0.21535821039211 no 723 0.225645534111209 258 1005053 YMR079W SEC14 SGTC_3129 9127257 49.47 µM 0.753205392757107 0.215376377201146 no 724 0.225663249622216 249 837894 SGTC_1733 st037357 54.9 µM 0.752690786130322 0.215534944083716 no 725 0.225817874003085 260 1272339 YGL099W LSG1 SGTC_2757 clomiphene 4.22 µM 0.751764834846515 0.215820429960271 no 726 0.226096246389227 277 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2814 7977482 42.97 µM 0.751698391154382 0.215840924057604 no 727 0.226116229073493 252 6456762 SGTC_2822 7994718 71.43 µM 0.751616791972634 0.215866094303892 no 728 0.226140771078352 290 1018011 SGTC_2649 anisomycin 9.56 µM 0.751163337243284 0.216005998840681 no 729 0.226277180850753 248 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1821 st053465 65.6 µM 0.750640898647296 0.216167252096266 no 730 0.226434400194423 234 675086 SGTC_165 k038-0023 64.381 µM 0.749964060497636 0.216376265158879 no 731 0.226638175252183 251 46368543 SGTC_3175 9106517 49.47 µM 0.749348691404896 0.216566397561868 no 732 0.22682353367243 254 41468073 SGTC_252 miconazole 1.30953 nM 0.744458093821794 0.218080892648682 no 733 0.228299692295158 246 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3278 9139605 49.47 µM 0.744155391319148 0.218174832200813 no 734 0.228391235924799 277 7958859 SGTC_2614 arthonioic acid 13.39 µM 0.743332373922207 0.218430362177172 no 735 0.22864023802018 250 6710684 SGTC_1504 k297-0033 30 µM 0.742267575832914 0.218761215708359 no 736 0.228962616422134 209 4388117 SGTC_633 0437-0093 97.7 µM 0.741918109930164 0.218869864404413 no 737 0.229068476326985 247 2831118 SGTC_2014 4013930 200 µM 0.740118979630619 0.219429703804641 no 738 0.229613901608999 260 64556 SGTC_2640 pentamidine 10.38 µM 0.738962612997335 0.219789966919883 no 739 0.229964850043568 256 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2051 5263410 176 µM 0.738855417928016 0.219823380461658 no 740 0.229997398125902 260 227584 SGTC_1280 0880-0253 10.1 µM 0.734637295762813 0.221140514976297 no 741 0.231280208883903 260 6836607 SGTC_3283 9109332 35.8195 µM 0.732892588354774 0.221686627890736 no 742 0.231811971967865 232 17027281 SGTC_2630 antimycin a 100 µM 0.729874608267452 0.22263310637997 no 743 0.232733417205282 278 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3176 9106582 49.47 µM 0.729762872156115 0.222668192468387 no 744 0.232767571341991 216 17018027 SGTC_607 4491-0986 66.8 µM 0.728861646114796 0.222951300309479 no 745 0.233043148972602 232 698981 YDR232W HEM1 SGTC_3101 9120531 49.47 µM 0.728380800851475 0.223102435117349 no 746 0.233190256314765 272 24824904 SGTC_791 1348-1292 225 µM 0.727083575099329 0.22351045788846 no 747 0.233587379924374 262 5437054 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.726890357481452 0.22357126787142 no 748 0.23364656228582 248 4174840 SGTC_184 1494-0393 24.714 µM 0.726762604145553 0.223611479921486 no 749 0.233685697568927 271 3090647 SGTC_416 estradiol valerate 100 µM 0.726011314514739 0.223848041456978 no 750 0.233915917180425 275 13791 A steroid. SGTC_334 1502-1024 68.5 µM 0.724607706805527 0.224290381839714 no 751 0.234346364790492 251 3296216 SGTC_1968 st069590 43.6 µM 0.724602169753826 0.224292127797684 no 752 0.234348063718526 268 6384066 SGTC_2678 equilin 100 µM 0.724023061684831 0.224474776304772 no 753 0.234525788500548 229 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1919 st067113 52.3 µM 0.72308385249306 0.224771178721993 no 754 0.234814184600562 284 1268243 SGTC_1730 st033808 45.1 µM 0.722362880941464 0.224998858618678 no 755 0.235035700995315 273 1045166 SGTC_3203 9113543 49.47 µM 0.721297211403215 0.225335631996439 no 756 0.235363336161588 257 17018012 SGTC_2812 7970281 58.44 µM 0.720300396872239 0.225650903985266 no 757 0.235670030224949 270 2233435 SGTC_1881 5652484 16 µM 0.719793043027418 0.225811465393128 no 758 0.235826214490733 269 2255129 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.719268816343084 0.225977434373733 no 759 0.235987652831098 270 5282362 SGTC_298 1391-0729 10 µM 0.7192237974047 0.225991690482428 no 760 0.236001519486912 262 3237558 SGTC_941 3237-0776 460 µM 0.714927729977315 0.227354459686636 no 761 0.237326850593843 261 760008 SGTC_2241 6772625 37.8075 µM 0.713414427818097 0.227835599500011 no 762 0.237794673892475 258 2285411 SGTC_3348 9149464 3.537 µM 0.713051981820984 0.227950920696266 no 763 0.237906795734095 255 1951442 SGTC_260 nsc-65238 3.989 µM 0.712377179660613 0.228165713217907 no 764 0.238115621442468 265 3246252 SGTC_545 4218-0007 221 µM 0.71173233502695 0.228371076412768 no 765 0.238315270253707 275 2840508 SGTC_935 2996-0153 430 µM 0.711634719164416 0.228402173114152 no 766 0.238345500856578 270 23738523 SGTC_139 0099-0334 718.624 µM 0.710360653143726 0.228808260215968 no 767 0.238740258191782 279 97690 SGTC_2766 oltipraz 83.91 µM 0.710219854371339 0.228853162310877 no 768 0.238783905301665 266 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_872 0588-0139 234 µM 0.710045988808068 0.228908616550148 no 769 0.238837809019858 248 2047100 SGTC_1550 gossypolone 36.6 µM 0.709990564285152 0.228926295728643 no 770 0.23885499374022 268 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1610 st001799 48.1 µM 0.709961849526247 0.228935455393381 no 771 0.238863897196948 268 621897 SGTC_2365 9042475 200 µM 0.709861432544738 0.228967488826845 no 772 0.23889503446804 268 6464479 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.70969819307716 0.229019568260829 no 773 0.238945656455862 258 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2997 9067075 71.4286 µM 0.707720815026918 0.229650952649494 no 774 0.239559324314064 272 27209819 SGTC_2696 st077691 74.316 µM 0.706361422647433 0.230085576789162 no 775 0.239981702444084 285 757133 SGTC_2302 7771753 200 µM 0.706216120947704 0.230132059773921 no 776 0.240026873287446 264 2203047 SGTC_708 3448-5400 146 µM 0.705842223365497 0.230251696259277 no 777 0.240143130464825 281 3462195 SGTC_66 0109-0187 42.4 µM 0.70552465500275 0.230353336325129 no 778 0.240241897116824 234 759417 SGTC_1917 st066507 28.5 µM 0.704312330104546 0.230741580330189 no 779 0.240619144663311 261 3156428 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.702094886514911 0.231452655867382 no 780 0.241309995532051 254 77254 SGTC_3148 9097893 49.47 µM 0.701534898953864 0.231632422120421 no 781 0.24148463155854 239 17174100 SGTC_1104 tacrolimus 29.8 µM 0.701480681239872 0.231649831129323 no 782 0.241501543374696 267 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1223 0764-0573 147 µM 0.701121456221669 0.231765194719854 no 783 0.241613610592849 255 1609797 SGTC_1033 k072-0102 21.3 µM 0.699744846655035 0.23220758326726 no 784 0.242043331973268 274 5965931 SGTC_1967 st070177 51.4 µM 0.698265618682034 0.232683472675037 no 785 0.242505548222414 272 5729214 SGTC_1704 st028805 70.8 µM 0.697476528484489 0.232937556152795 no 786 0.242752311643666 280 2876101 SGTC_386 1509-0011 3.07 µM 0.696697713599611 0.233188482067349 no 787 0.242995994987805 260 3107280 SGTC_2023 5144124 124 µM 0.695444144151032 0.233592683811602 no 788 0.24338850199266 274 2830192 SGTC_1907 st060210 83.7 µM 0.695411034106989 0.233603365099326 no 789 0.243398873769819 271 688793 SGTC_187 1488-2104 32.728 µM 0.695391936522814 0.233609526095933 no 790 0.243404856228882 269 2852859 SGTC_2688 kanamycin b 96.69 µM 0.695203811067271 0.233670221325076 no 791 0.243463792160929 263 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2075 5212009 200 µM 0.693991228280341 0.234061648643321 no 792 0.243843854951069 281 780898 SGTC_54 0159-0055 9 µM 0.693837455629605 0.23411131309764 no 793 0.243892075156209 295 3319099 SGTC_119 0121-0043 24.815 µM 0.692469980507929 0.23455322759786 no 794 0.244321115831851 284 1092378 SGTC_1390 3413-2614 145 µM 0.691765559631387 0.23478104882319 no 795 0.244542284135294 293 3421432 SGTC_3300 9124615 50.48 µM 0.690477164776519 0.235198053076691 no 796 0.244947082665091 262 24824903 SGTC_1216 1165-0504 9.65 µM 0.690421579048461 0.235216053254681 no 797 0.244964555157429 274 6304004 SGTC_174 3553-0389 74.3 µM 0.688592120211759 0.235808906351813 no 798 0.245539990591153 260 738071 SGTC_2249 haloperidol 116.36 µM 0.68817817948947 0.235943161880061 no 799 0.245670291594771 278 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3005 9076496 71.4286 µM 0.6875701119739 0.236140455923962 no 800 0.245861767496208 272 21368410 SGTC_2054 5233173 129 µM 0.687481110851644 0.236169340917392 no 801 0.245889800000732 221 6889 SGTC_1879 gemcitabine 100 µM 0.685494427000278 0.236814618325488 no 802 0.246515988080426 299 60750 A nucleoside analog which inhibits DNA replication. SGTC_2653 dihydrofissinolide 100 µM 0.685371966500121 0.236854425346386 no 803 0.246554614661299 272 6857746 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.683782738699085 0.237371353408909 no 804 0.247056183996033 273 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1234 0326-0494 15.5 µM 0.683734148154068 0.237387168207107 no 805 0.24707152804374 285 1547813 SGTC_2144 5628481 200 µM 0.682179897172517 0.237893336434292 no 806 0.247562602270171 271 2818399 SGTC_2477 5967686 25.23 µM 0.679338579073699 0.238820187780241 no 807 0.248461678710425 267 776118 SGTC_3014 9081533 49.47 µM 0.678970063716105 0.238940543763465 no 808 0.248578415128262 302 21367265 SGTC_2751 anetholtrithion 17.25 µM 0.678919299855446 0.238957125683037 no 809 0.248594498134853 276 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_726 3448-4391 34.2 µM 0.678868484104419 0.238973725182663 no 810 0.248610598136505 279 1356692 SGTC_1720 st037298 9.481 µM 0.677920956881663 0.23928336037083 no 811 0.248910905776505 295 597396 SGTC_787 4152-0075 138 µM 0.677870778308986 0.239299763952189 no 812 0.24892681466789 270 9566539 SGTC_2387 9077560 195.08 µM 0.677750835887669 0.239338976111057 no 813 0.248964844067199 261 5303272 SGTC_1824 st053723 68.6 µM 0.676908711056069 0.239614386455255 no 814 0.249231938399126 280 675225 SGTC_167 3672-0051 66.205 µM 0.676693299905184 0.239684862762092 no 815 0.249300284204869 264 3237971 SGTC_14 0354-0009 295 µM 0.675594976249535 0.24004437836173 no 816 0.24964891600062 294 1713507 SGTC_2295 7971645 200 µM 0.67541904424648 0.240101993702499 no 817 0.249704784694187 274 2978226 YKL099C UTP11 SGTC_535 2293-4129 48.2 µM 0.675383693797058 0.240113571403888 no 818 0.24971601132905 295 396118 YIL048W NEO1 SGTC_422 cantharidin 155 µM 0.674957035166038 0.240253331284907 no 819 0.249851531187534 280 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2760 etidronate 98.04 µM 0.673387220936472 0.240767934183291 no 820 0.250350488201601 280 3305 A chelator and antioxidant. SGTC_997 3996-0078 137 µM 0.671871663914045 0.241265319467424 no 821 0.250832700539893 263 735687 SGTC_3206 9114350 49.47 µM 0.671755369052308 0.241303508919924 no 822 0.250869722958723 266 17087243 SGTC_1722 st034304 3.6505 µM 0.671520901698467 0.241380514396197 no 823 0.250944374333137 293 4036148 YLR033W RSC58 SGTC_2536 dehydroabietamide 32.04 µM 0.670924245992214 0.241576532608516 no 824 0.251134394807738 276 3983547 SGTC_2035 5154463 94.595 µM 0.670339193599326 0.241768822702977 no 825 0.251320793784147 290 2769623 SGTC_3171 9103192 49.47 µM 0.668866257009135 0.24225330270115 no 826 0.251790398297499 284 13018434 SGTC_3184 9108758 49.47 µM 0.667491285551774 0.242706034342406 no 827 0.252229187113156 291 902885 SGTC_3211 9128781 49.47 µM 0.666217853940912 0.243125740537687 no 828 0.252635931323452 276 17194361 SGTC_1448 4255-0083 152 µM 0.665808364163916 0.243260786288729 no 829 0.252766798994838 308 5399660 SGTC_2570 licareol 100 µM 0.664711914586519 0.24362258425685 no 830 0.253117385855164 284 443158 SGTC_1864 st057645 30.4 µM 0.664698403176335 0.243627044459389 no 831 0.253121707687741 284 688666 SGTC_55 0767-0285 6.563 µM 0.664421472637732 0.243718470706541 no 832 0.253210296734219 297 3116166 SGTC_419 nsc-638432 893 µM 0.663529479679953 0.244013080420519 no 833 0.253495752753584 269 368090 SGTC_1900 st060200 72.8 µM 0.662931719116956 0.244210617762044 no 834 0.253687142962364 275 688945 SGTC_2958 9077254 16.72 µM 0.662550427858655 0.244336665178168 no 835 0.253809263935768 268 16457351 SGTC_466 geldanamycin 89.2 µM 0.661918963601233 0.244545491981469 no 836 0.254011578837305 257 5288382 HSP90 inhibitor. SGTC_121 0557-0495 61.343 µM 0.661785831651186 0.244589531316942 no 837 0.254054243794568 303 3104427 SGTC_178 4092-0806 87.505 µM 0.660574113910623 0.244990557342679 no 838 0.254442737204317 270 2169044 SGTC_3236 9132701 49.47 µM 0.659790547330282 0.245250072119931 no 839 0.254694125096597 289 24282524 SGTC_342 k048-0088 23.3 µM 0.657488561583621 0.246013336651551 no 840 0.255433411726783 286 6820570 SGTC_826 1683-5028 118 µM 0.653492894634983 0.247341191583392 no 841 0.256719284323145 288 722377 SGTC_1419 3993-2473 62.6 µM 0.649502855511861 0.248670989797626 no 842 0.258006700673102 294 704026 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.649039239029666 0.248825750211714 no 843 0.258156506906047 274 688667 SGTC_603 3794-0023 45.9 µM 0.648899069971893 0.248872550317802 no 844 0.258201807957096 296 3802260 SGTC_629 3448-6466 76.7 µM 0.64881864297409 0.248899405663764 no 845 0.258227802911875 299 573744 SGTC_1380 2291-0730 164 µM 0.647843363553354 0.24922518353637 no 846 0.258543132661103 276 2999191 SGTC_1000 4048-0884 8.67 µM 0.647565051953945 0.249318191037633 no 847 0.258633153612968 298 13040088 SGTC_2433 5607874 27.82 µM 0.647039884282431 0.249493744331573 no 848 0.258803065298198 295 2252428 SGTC_825 1988-2224 89.6 µM 0.645534332712818 0.249997384664666 no 849 0.259290488381414 287 1180859 SGTC_2466 5983409 37.09 µM 0.645248796423281 0.250092963699189 no 850 0.259382984386815 286 2879657 SGTC_2692 st077426 47.7 µM 0.645231282921515 0.25009882671484 no 851 0.259388658227315 283 25238571 SGTC_3133 9127736 49.47 µM 0.643479199147078 0.25068574220718 no 852 0.259956603827881 281 27243420 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.642780656662679 0.250919944181147 no 853 0.260183218116226 293 2374 Ca(2+)-ATPase inhibitor. SGTC_2269 7935389 174.42 µM 0.641878370317714 0.251222627147429 no 854 0.260476079607207 286 97605 SGTC_3301 9125354 19.7965 µM 0.640814040453046 0.251579917651637 no 855 0.26082175480742 266 41905162 SGTC_2377 9073351 62.6 µM 0.640597281246499 0.25165271558132 no 856 0.260892183213969 318 7337946 YHR072W ERG7 SGTC_623 k072-0108 16.9 µM 0.639993675105833 0.251855493509814 no 857 0.261088355681441 297 5382803 SGTC_35 0133-0054 64.071 µM 0.63941971527056 0.252048391909779 no 858 0.261274963381242 287 99677 SGTC_2996 9066192 71.4286 µM 0.639148435856102 0.252139591550635 no 859 0.261363186472969 277 6472854 SGTC_2061 5245884 80.95 µM 0.638988194795817 0.252193470114067 no 860 0.261415305840563 309 573863 SGTC_705 1124-0212 310 µM 0.638902625569086 0.252222243921918 no 861 0.261443139931601 312 9554485 SGTC_1885 st057546 99.9 µM 0.638120799205329 0.2524852237423 no 862 0.261697524080806 275 702008 SGTC_2255 7941087 197.44 µM 0.63490118037261 0.253569714911858 no 863 0.262746433595883 288 935561 SGTC_3231 9132313 49.47 µM 0.632661846756338 0.25432544879692 no 864 0.263477245012283 293 4905967 SGTC_2667 digitoxin 100 µM 0.632457231037958 0.254394561660217 no 865 0.263544073493562 270 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1247 0448-0043 5.84 µM 0.630257676351077 0.25513812440916 no 866 0.26426300452642 303 3089013 YGL099W LSG1 SGTC_630 4356-0227 183 µM 0.629470339842311 0.255404560675174 no 867 0.264520590323744 314 779312 SGTC_2520 obtusaquinone 4.71 µM 0.627361635381783 0.256118866098149 no 868 0.265211104888778 298 5967872 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.626784714886842 0.256314474290117 no 869 0.265400182116051 285 279621 SGTC_576 1073-0113 22.7 µM 0.625994056650676 0.256582677916054 no 870 0.265659419823078 324 5439563 SGTC_1782 st039423 80.636 µM 0.625255379462227 0.256833380763048 no 871 0.265901730165777 297 2068169 SGTC_201 4262-0159 12.803 µM 0.624801717145342 0.2569874143479 no 872 0.266050601773949 293 1341029 SGTC_1332 1480-0653 17.5 µM 0.623829931567059 0.257317529830422 no 873 0.266369640183025 293 5749438 SGTC_138 0850-0259 40.9225 µM 0.623174201467999 0.257540405757086 no 874 0.266585026515805 288 6813004 SGTC_3077 9117319 49.47 µM 0.621616471435097 0.25807026392515 no 875 0.267097043788842 312 17154678 SGTC_2938 9059746 27.26 µM 0.618534203378136 0.259120353631269 no 876 0.268111629354318 304 6471769 SGTC_743 1275-0778 158 µM 0.617864481340615 0.259348811247112 no 877 0.268332337009534 305 2849257 YMR203W TOM40 SGTC_439 amiodarone 34.4 µM 0.617581613588593 0.259445335204562 no 878 0.268425583839611 300 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1402 3909-7673 35.9 µM 0.616246165506788 0.259901285311403 no 879 0.268866031757156 286 5328014 SGTC_2362 9071156 126 µM 0.615226970915895 0.260249537702786 no 880 0.269202419219326 301 653133 SGTC_731 3966-0296 387 µM 0.614789228895412 0.260399185185747 no 881 0.269346961739695 288 660956 SGTC_142 0335-0849 62.6745 µM 0.614007047231192 0.260666693902341 no 882 0.269605335168172 289 3889043 YPR107C YTH1 SGTC_2310 7668677 200 µM 0.612215384458783 0.261279981102319 no 883 0.270197632105591 324 2197143 SGTC_2796 7949634 45.45 µM 0.611417261343684 0.261553417570944 no 884 0.270461689031627 308 2971588 SGTC_890 0929-0006 47.2 µM 0.611106723305599 0.261659847386502 no 885 0.2705644645578 297 1378169 SGTC_3237 9133362 49.47 µM 0.610181131078957 0.261977204758111 no 886 0.270870913825149 314 43845137 SGTC_3183 9108214 49.47 µM 0.609730644528406 0.262131734234387 no 887 0.271020125597985 278 4974831 SGTC_393 acivicin 6.25 µM 0.608317474823624 0.262616793850585 no 888 0.271488466633898 292 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1486 3970-0793 4.53 µM 0.608234850246845 0.262645168305873 no 889 0.271515861858062 324 2844330 SGTC_727 3032-0951 202 µM 0.607835523344954 0.262782324953476 no 890 0.271648283150931 311 3652836 SGTC_360 0957-0399 1.01 µM 0.607651387555277 0.26284558233645 no 891 0.271709355480042 300 6752301 YPR165W RHO1 SGTC_1355 1499-0035 1.68 µM 0.606167957536436 0.263355478742632 no 892 0.272201613987009 310 1548538 SGTC_1634 st006576 41 µM 0.606108597776568 0.263375892857432 no 893 0.272221321032568 294 3915356 SGTC_874 0599-0792 117 µM 0.605702521728527 0.263515566082253 no 894 0.272356154594236 308 765305 SGTC_1794 st048918 76.9 µM 0.603790315895292 0.264173792884519 no 895 0.27299152935282 294 672303 SGTC_500 h-89 112 µM 0.60267235974047 0.264559007584206 no 896 0.273363336331703 317 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2012 4023501 200 µM 0.602079491041571 0.264763408541702 no 897 0.273560612779985 334 3477460 SGTC_2595 hexamethylquercetagetin 100 µM 0.599943014894543 0.265500658274653 no 898 0.274272106913828 323 386331 SGTC_101 0490-5701 117.494 µM 0.597005787930607 0.266515926439202 no 899 0.275251758160112 304 4661669 SGTC_196 k015-0023 18.111 µM 0.596425901549266 0.266716599109659 no 900 0.275445370661918 297 5211998 SGTC_722 3534-0461 190 µM 0.59629429730977 0.266762152065857 no 901 0.275489320019879 290 658262 SGTC_2439 5492030 7.2 µM 0.59055916365101 0.268751099463799 no 902 0.277407916642022 298 5722370 SGTC_932 2857-0803 154 µM 0.59042012850037 0.268799409253637 no 903 0.27745450959186 311 674898 SGTC_1674 st016616 23.6 µM 0.590218678694174 0.268869413662686 no 904 0.277522025497968 295 625830 SGTC_1437 4092-1038 11.6 µM 0.589799022522334 0.269015274829817 no 905 0.277662699050757 314 3977136 SGTC_2215 7188065 200 µM 0.588458681599815 0.269481407033584 no 906 0.278112229816587 310 940217 SGTC_3185 9108267 49.47 µM 0.588081061613555 0.269612805509178 no 907 0.278238942109269 300 4910486 SGTC_72 0744-0168 198.391 µM 0.585712104931632 0.270437850759954 no 908 0.279034499056862 345 677577 SGTC_1629 st005085 44.9 µM 0.585657982927474 0.270456714760909 no 909 0.279052687543939 307 24207091 SGTC_1694 st024011 44.9 µM 0.584963612084503 0.270698793167593 no 910 0.279286092105215 336 2787533 SGTC_3118 9124250 49.47 µM 0.584022345044509 0.271027119606882 no 911 0.279602639286994 307 1504786 SGTC_3010 9080089 71.4286 µM 0.581176956638137 0.272020835149111 no 912 0.280560598236708 297 17027233 SGTC_3098 9119039 49.47 µM 0.580350028588083 0.272309968621601 no 913 0.280839298260772 311 17161528 SGTC_2867 9039098 71.43 µM 0.580129142478877 0.272387226768961 no 914 0.280913766275661 317 6463460 SGTC_1752 st044819 83.042 µM 0.578310782330363 0.273023638255275 no 915 0.281527158054779 303 441209 YML126C ERG13 SGTC_38 0929-0051 58.268 µM 0.578119740444392 0.273090544150223 no 916 0.281591640158513 327 1379719 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.577932950801493 0.27315596869814 no 917 0.281654693894632 336 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3204 9114183 49.47 µM 0.576053593964229 0.273814660142492 no 918 0.282289478438226 295 17027248 SGTC_1066 ketoconazole 628 nM 0.574273830783288 0.274439168500062 no 919 0.282891257469642 328 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2289 7946404 165.07 µM 0.573912910118963 0.274565899101404 no 920 0.283013368172276 322 1246120 YPR165W RHO1 SGTC_940 3232-1287 54.8 µM 0.573897307085209 0.274571378468456 no 921 0.283018647735104 330 1585493 YIL048W NEO1 SGTC_2525 harmine 47.85 µM 0.573876421326725 0.274578713071204 no 922 0.283025714875407 301 5280953 A monoamine oxidase inhibitor SGTC_3087 9117406 49.47 µM 0.568514459245327 0.276464903149885 no 923 0.284842845200488 291 42546093 SGTC_465 cgp-37157 41 µM 0.568260320275382 0.276554459680411 no 924 0.284929109048158 305 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1044 1222-0021 1.78 µM 0.565872704135215 0.277396530169032 no 925 0.285740159131523 298 4306703 SGTC_977 1348-1378 135 µM 0.564678431954279 0.277818198903149 no 926 0.286146253439242 310 X977 SGTC_400 oxethazaine 37.5 µM 0.563832604119071 0.278117029520794 no 927 0.286434030226696 317 4621 A local anesthetic. SGTC_3269 9137823 49.47 µM 0.563740460740703 0.278149593205383 no 928 0.286465388547991 304 17682936 SGTC_1392 3455-1037 33.9 µM 0.563626663206029 0.278189812085488 no 929 0.286504118480278 318 981132 SGTC_2507 purpurin 79.67 µM 0.563606391159719 0.278196977028618 no 930 0.286511018143348 316 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_808 0711-0032 135 µM 0.562397174313001 0.278624524797031 no 931 0.286922721925921 317 4252555 SGTC_1928 4'-methoxychalcone 40.3 µM 0.56217814338061 0.278702002678641 no 932 0.286997325672145 337 641818 SGTC_1077 5-fluorocytosine 377 nM 0.561723187641388 0.278862967829981 no 933 0.287152316714415 345 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_845 0330-0138 4.51 µM 0.561684464612459 0.278876670280454 no 934 0.287165510426494 332 9039800 SGTC_3316 9136639 10.545 µM 0.560368010952729 0.279342702620113 no 935 0.287614223198163 305 4903665 SGTC_3229 9132204 49.47 µM 0.559844482496013 0.279528139869942 no 936 0.287792759748234 326 17682924 SGTC_183 3914-0051 30.55 µM 0.559488452182683 0.279654282302773 no 937 0.287914205061255 306 1596232 SGTC_2879 9041815 71.43 µM 0.557657094127376 0.280303573258374 no 938 0.28853928070758 302 4942971 SGTC_723 4182-0001 115 µM 0.557390824803738 0.280398037328926 no 939 0.288630216463064 321 744821 YLR208W SEC13 SGTC_1693 xanthone 101.9 µM 0.553484343048006 0.281785704517175 no 940 0.289965899413626 338 7020 An insecticide. SGTC_370 0180-0345 38.7 µM 0.552405778177431 0.282169416457475 no 941 0.290335186342175 309 3989527 SGTC_1254 0550-0035 264 µM 0.552189159726886 0.28224651129852 no 942 0.290409380301181 328 15121435 SGTC_789 1309-1135 70.6 µM 0.55159309415264 0.282458704265488 no 943 0.290613584452137 312 3092424 SGTC_2262 9014885 67.46 µM 0.551117260152486 0.282628151126191 no 944 0.290776647063979 317 6457424 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.55107316563562 0.282643855876776 no 945 0.290791759892295 306 688664 SGTC_2941 9056145 11.23 µM 0.550209548264317 0.282951527288515 no 946 0.291087827640313 322 2119517 SGTC_1895 st058434 18.3 µM 0.548996081746211 0.283384107100526 no 947 0.291504069394132 347 5393175 SGTC_1295 1013-0063 9.78 µM 0.54674206564545 0.28418846526927 no 948 0.292277974988815 327 6826038 SGTC_1995 st072814 61.1 µM 0.545978797779766 0.284461088859408 no 949 0.29254025577367 313 5769371 SGTC_134 0269-0018 6.916 µM 0.545974926641652 0.284462471868737 no 950 0.29254158628676 330 4378915 SGTC_1605 st000082 49.1 µM 0.543456646011867 0.285362837056287 no 951 0.293407716531117 333 1114022 SGTC_1927 st060202 13.8 µM 0.542578196886602 0.285677229480593 no 952 0.293710127065362 318 688887 SGTC_389 tpck 16.7 µM 0.542575202949028 0.285678301277185 no 953 0.29371115799006 311 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1248 0469-0687 58.6 µM 0.542484426010727 0.285710799327096 no 954 0.293742416680657 326 4017482 SGTC_790 1575-0012 79.1 µM 0.541258842829939 0.286149728903033 no 955 0.294164592163676 353 378741 YLR208W SEC13 SGTC_835 0312-0010 67.2 µM 0.540899716336189 0.286278406890837 no 956 0.294288353220595 321 1626196 SGTC_3142 9086498 49.47 µM 0.540361462686853 0.286471319050659 no 957 0.294473889540463 311 25236367 SGTC_161 4065-0411 162.148 µM 0.539409519483709 0.286812650059979 no 958 0.29480215698005 330 1906281 YLR208W SEC13 SGTC_3263 9137018 49.47 µM 0.539086487557507 0.28692852094006 no 959 0.29491358941249 315 43844957 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.538444158820948 0.287158988793192 no 960 0.295135223472 327 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_77 0828-0286 12.516 µM 0.537641092137187 0.287447252711151 no 961 0.295412427630241 309 745345 SGTC_3234 9132280 49.47 µM 0.537360528952814 0.287547994208959 no 962 0.295509301213159 313 17612295 SGTC_984 1492-0255 2.91 µM 0.536856318378296 0.287729082459287 no 963 0.295683433053824 340 1585198 SGTC_2965 9082772 38.63 µM 0.536548719744965 0.287839583589072 no 964 0.295789687054617 268 16459634 SGTC_2944 9067346 25.62 µM 0.535746226929464 0.288127963852964 no 965 0.29606697522547 328 6473075 SGTC_501 nsc-95397 161 µM 0.533950814501271 0.288773648530769 no 966 0.296687782036627 331 262093 SGTC_2903 5923464 63.88 µM 0.532491370538623 0.289299010201845 no 967 0.29719285850038 316 2876576 SGTC_3111 9122088 49.47 µM 0.532472662277099 0.289305747601779 no 968 0.297199335504892 322 16876704 SGTC_3164 9100705 49.47 µM 0.532112277990577 0.289435547062797 no 969 0.297324117072642 317 17174235 SGTC_1165 k072-0275 30.3 µM 0.531476853598714 0.289664474220404 no 970 0.297544188427477 320 6153523 YGL055W OLE1 SGTC_1409 3909-8004 61.9 µM 0.530644935219147 0.28996432154466 no 971 0.297832425394457 319 2119279 SGTC_1989 st071868 50.2 µM 0.529209169348321 0.290482154933875 no 972 0.298330178289092 338 16414057 SGTC_2004 4023728 41.89 µM 0.52916422319731 0.290498372512621 no 973 0.298345766381506 354 360084 YDR527W RBA50 SGTC_745 0469-0705 296 µM 0.529029106818136 0.290547128082395 no 974 0.298392629280718 359 3486736 SGTC_1793 st048256 72.231 µM 0.52860608239711 0.290699797519178 no 975 0.298539370019447 333 672022 SGTC_1389 3405-0187 19 µM 0.526917792044508 0.29130947455848 no 976 0.299125338921571 308 799890 SGTC_2831 7999036 19.48 µM 0.52648400069143 0.291466222021073 no 977 0.29927598273656 351 2988270 SGTC_310 1273-0058 1.06 µM 0.525788742458515 0.291717530731741 no 978 0.299517498572982 301 2734232 SGTC_435 c-PAF 6.7 µM 0.52421654479636 0.292286190869609 no 979 0.300063967369289 325 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1738 st035555 74 µM 0.520674425060629 0.293569252839254 no 980 0.301296796688913 362 5331140 SGTC_2739 tacrine 100.86 µM 0.519536261619025 0.293982082697889 no 981 0.301693416381947 318 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3353 9151644 39.2805 µM 0.519284011915779 0.294073613973955 no 982 0.301781350467198 347 4909158 SGTC_3205 9113483 49.47 µM 0.518964519787614 0.294189563726132 no 983 0.301892741752721 376 17018033 SGTC_1299 1079-1439 3.74 µM 0.5184507173368 0.294376076664639 no 984 0.302071918281939 336 323161 SGTC_660 4031-1742 102 µM 0.51704461881425 0.294886776618631 no 985 0.302562506063025 329 6738706 SGTC_3292 9120825 59.784 µM 0.515023707066936 0.295621493227162 no 986 0.303268226912458 344 24824900 SGTC_2044 5102272 200 µM 0.514251511189216 0.295902452466037 no 987 0.30353807893919 322 592666 SGTC_751 0833-0568 350 µM 0.51396665701671 0.296006126047236 no 988 0.303637651313826 348 6954252 SGTC_390 dec-rvkr-cmk 16.7 µM 0.511150362482119 0.29703202153269 no 989 0.304622886534362 326 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2899 9053889 58.44 µM 0.511139100517326 0.297036127206725 no 990 0.304626829204127 331 6470052 SGTC_3000 9075062 71.4286 µM 0.510915814806725 0.297117533844362 no 991 0.304705003359493 313 17057871 SGTC_1274 0865-0114 173 µM 0.510763940384246 0.297172910820407 no 992 0.304758180934619 312 870624 SGTC_415 dibenzyl ketone 100 µM 0.510673363815203 0.297205939407454 no 993 0.30478989753628 358 7593 SGTC_2681 menadione 3.18 µM 0.510647269352265 0.297215455018913 no 994 0.304799035135021 342 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2616 abietic acid 100 µM 0.509450684366356 0.297651951422481 no 995 0.305218178649043 342 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_613 3914-0030 117 µM 0.507185571591999 0.298479030848266 no 996 0.306012308886895 321 1145395 SGTC_1347 1493-0251 600 nM 0.50693868737654 0.29856924089128 no 997 0.3060989197222 319 3986378 SGTC_904 1141-0088 396 µM 0.506028606674954 0.298901886095979 no 998 0.306418283836957 337 1378119 SGTC_3334 9142812 21.919 µM 0.504540516002493 0.299446163140013 no 999 0.306940799156679 350 45283678 SGTC_1507 4075-3230 155 µM 0.503728523779885 0.299743342958672 no 1000 0.307226080653594 346 659771 SGTC_2337 9009472 200 µM 0.503592395619771 0.299793177371067 no 1001 0.307273918702863 358 5742383 SGTC_529 4076-0302 30.3 µM 0.502828016338791 0.300073074445229 no 1002 0.307542597149782 337 5816522 SGTC_525 k781-2675 26.7 µM 0.502776217429684 0.300092046220002 no 1003 0.307560808145494 337 3651118 YDL195W SEC31 SGTC_2259 7964009 200 µM 0.50118754390758 0.300674174194969 no 1004 0.308119569891739 309 313134 SGTC_1159 4092-0538 61.2 µM 0.499286248743551 0.301371523393815 no 1005 0.308788870618425 341 717301 SGTC_2199 6590217 200 µM 0.498501758431469 0.301659467555917 no 1006 0.309065215057983 336 703109 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.498497879194382 0.301660891722391 no 1007 0.309066581826134 374 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_3038 9091290 49.47 µM 0.497924661257384 0.301871367812708 no 1008 0.30926857223387 368 25236843 SGTC_671 0560-0003 407 µM 0.497000783671258 0.302210739107571 no 1009 0.309594249347066 362 3238678 SGTC_610 4215-0184 155 µM 0.496110193158397 0.302538044930785 no 1010 0.309908333987675 319 5605015 SGTC_2177 5811945 192 µM 0.495951643406513 0.302596331081503 no 1011 0.309964264304089 340 5343475 SGTC_2985 9022375 71.43 µM 0.495648090650614 0.302707937358008 no 1012 0.310071358430115 333 4939335 SGTC_1788 fluconazole 20 µM 0.495450505311661 0.302780592837578 no 1013 0.310141075660789 365 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2445 5742597 35.57 µM 0.494976673981146 0.302954860465465 no 1014 0.310308293037947 332 1774255 SGTC_359 0081-0058 15.9 µM 0.494969866335462 0.302957364536366 no 1015 0.310310695775042 406 3494159 SGTC_2282 7944268 200 µM 0.490694285077439 0.304531886698477 no 1016 0.311821344567789 339 2970414 SGTC_2421 5690543 90.72 µM 0.488999615429538 0.305156970348502 no 1017 0.312420984559509 369 3397993 SGTC_1273 0849-0096 14.1 µM 0.48879855833763 0.305231168598119 no 1018 0.312492159387326 351 5286025 SGTC_922 1866-0035 480 µM 0.486826755008058 0.30595926809306 no 1019 0.31319055417976 349 3156169 SGTC_1735 st034310 56.75 µM 0.485637526246961 0.306398768735022 no 1020 0.313612092568839 348 871153 SGTC_1338 1486-1223 76 µM 0.484200758821681 0.306930123388954 no 1021 0.314121699211482 344 3444526 SGTC_1934 st074720 32.6 µM 0.483935289610234 0.307028345387681 no 1022 0.314215897254636 337 17250992 SGTC_1272 0839-0021 27 µM 0.48301530879826 0.307368839844762 no 1023 0.314542433211404 368 5027250 SGTC_1220 1838-0075 193 µM 0.482954721586252 0.307391269633783 no 1024 0.314563942998645 327 5529645 SGTC_144 4161-2749 112.381 µM 0.482817389422851 0.307442113581275 no 1025 0.314612701254628 349 797501 YMR168C CEP3 SGTC_442 cape 100 µM 0.482791218658565 0.307451803100335 no 1026 0.314621993259968 342 5281787 SGTC_541 4513-1321 94 µM 0.482645862184871 0.307505622633815 no 1027 0.314673604631986 343 747515 SGTC_1625 st003711 30.1 µM 0.482187914542729 0.307675208931923 no 1028 0.314836230665517 341 24207034 YER133W GLC7 SGTC_939 1165-0479 45.3 µM 0.479530834833974 0.30865998383223 no 1029 0.315780518771288 370 1377347 SGTC_1096 rimcazole 32.2 µM 0.478105184962162 0.309188930893962 no 1030 0.316287670941661 366 18528119 A dopamine reuptake inhibitor. SGTC_1038 k292-0204 154 µM 0.47723314270966 0.309512672665127 no 1031 0.316598056544534 330 4454212 SGTC_2639 lactacystin 53 µM 0.476626604564193 0.309737934443664 no 1032 0.316814017585086 329 3870 A proteasome inhibitor. SGTC_780 0109-0199 192 µM 0.476147460009688 0.309915934141949 no 1033 0.316984663629055 372 610414 SGTC_2077 5212015 200 µM 0.47570339011873 0.310080943581712 no 1034 0.317142852691819 339 780900 SGTC_972 1319-0219 195 µM 0.475697311043104 0.310083202736821 no 1035 0.317145018446112 359 23903702 SGTC_1718 roemerine 11.9335 µM 0.475650773134421 0.310100497767262 no 1036 0.317161598423577 319 235224 An aporphine alkaloid with mutagenic activity. SGTC_2825 7998094 58.44 µM 0.47396604111243 0.310726882712455 no 1037 0.317762061803009 351 2987815 SGTC_451 chloral hydrate 100 µM 0.47113435231196 0.311780943561653 no 1038 0.31877239749713 358 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1797 st048695 56.8 µM 0.470901104194637 0.311867836195319 no 1039 0.318855679742285 371 592262 YIL048W NEO1 SGTC_819 1013-0258 27.7 µM 0.470476760415479 0.312025945134485 no 1040 0.319007216974518 344 5753198 SGTC_1854 st056233 32.9 µM 0.469506125296032 0.312387730420678 no 1041 0.319353953804644 354 5393174 SGTC_1573 oleylamine 1.06 µM 0.46931696904559 0.312458255795228 no 1042 0.319421543886944 351 5356789 An amine of the fatty acid oleic acid. SGTC_135 0933-0004 26.348 µM 0.468928240850032 0.312603211514609 no 1043 0.319560464664634 348 21230617 YGL099W LSG1 SGTC_2100 5377183 190 µM 0.467281067138458 0.313217759755068 no 1044 0.320149400118156 340 2844202 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.466282039285805 0.313590742632514 no 1045 0.320506816552189 356 2724278 An inhibitor of dopamine biosynthesis. SGTC_1441 4106-0040 13 µM 0.466243922023476 0.313604977331475 no 1046 0.320520456845314 347 2904180 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.46587995832692 0.313740911709707 no 1047 0.320650713754442 348 688669 SGTC_302 1094-0063 18.9 µM 0.465331778092326 0.313945695621813 no 1048 0.32084694056224 355 5440289 SGTC_933 2914-0560 114 µM 0.464342347249531 0.314315462758629 no 1049 0.321201244299086 324 463887 SGTC_1199 1638-0010 4.46 µM 0.464118119106956 0.314399286551694 no 1050 0.321281560442348 349 3111136 SGTC_2765 myclobutanil 7.74 µM 0.462498556789829 0.315005015760172 no 1051 0.321861918521023 370 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2232 chlorophetanol 41.5365 µM 0.461598138224656 0.315341994939014 no 1052 0.322184764973264 359 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_297 0986-0032 24 µM 0.460774517553997 0.315650367299619 no 1053 0.32248019295863 356 2847425 SGTC_3314 9135860 59.4275 µM 0.459625281177549 0.316080868197813 no 1054 0.322892604785568 357 25252478 SGTC_827 3253-0474 693 µM 0.458893932489403 0.316354959424412 no 1055 0.323155168061346 340 5402065 SGTC_1394 3474-0001 65.7 µM 0.45888009544417 0.316360146176638 no 1056 0.323160136582561 337 5017666 YIL048W NEO1 SGTC_3181 9108277 49.47 µM 0.458622495866853 0.316456712778982 no 1057 0.323252639616411 380 17097298 SGTC_1005 4092-0690 4.4 µM 0.458393202435761 0.316542678756849 no 1058 0.323334987213997 363 1529343 SGTC_1031 k035-0009 16 µM 0.45820594864085 0.316612890718142 no 1059 0.323402243272516 374 5180959 SGTC_2712 st079126 47.7 µM 0.457279840672875 0.316960237714576 no 1060 0.323734958843457 355 3152970 SGTC_1930 st074634 34.3 µM 0.456950648743265 0.317083743666415 no 1061 0.323853259017608 342 684253 YOR116C RPO31 SGTC_721 1187-1332 279 µM 0.454389236483978 0.318045427486583 no 1062 0.324774349017316 350 25730 SGTC_1345 1488-0192 31.4 µM 0.454183348059431 0.318122781834483 no 1063 0.324848433629016 364 658348 SGTC_538 2922-0838 53.3 µM 0.453878457050582 0.318237347020359 no 1064 0.324958154960161 332 777039 SGTC_50 0929-0078 56.389 µM 0.450482644298402 0.319514523616802 no 1065 0.326181232906661 365 1377751 SGTC_2905 7799065 20.05 µM 0.450121621958676 0.319650431669599 no 1066 0.326311373492574 371 1296806 SGTC_668 1682-0499 62.6 µM 0.449626012833302 0.319837044811051 no 1067 0.326490064088384 355 682214 SGTC_3265 9137266 49.47 µM 0.44934753747163 0.319941919962959 no 1068 0.32659048514085 342 17224265 SGTC_982 1491-0518 27.5 µM 0.447669838195004 0.320574053830048 no 1069 0.327195746284431 348 3091256 SGTC_3275 9138069 49.47 µM 0.44756421975857 0.320613866838269 no 1070 0.327233865324918 364 17617007 SGTC_1899 st063254 59.6 µM 0.446089245652665 0.321170075753351 no 1071 0.327766390430452 348 3093813 SGTC_2015 5119600 184 µM 0.445949965231936 0.321222618800039 no 1072 0.327816694402349 385 2828786 SGTC_1742 st038235 28.8875 µM 0.444772660392343 0.321666895781321 no 1073 0.328242026870818 392 564103 YBR002C RER2 SGTC_1334 1486-0610 236 µM 0.444634891652885 0.321718901959963 no 1074 0.328291814035841 348 3742339 SGTC_1217 1183-1422 255 µM 0.443338897347448 0.322208296387147 no 1075 0.328760312447926 357 2849664 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.443249642650577 0.322242012178537 no 1076 0.328792587695482 392 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_740 k014-0057 261 µM 0.439959015148209 0.323486059448433 no 1077 0.3299833958389 391 4012779 SGTC_1789 tunicamycin 25 nM 0.439098614301784 0.323811667063545 no 1078 0.330295041560074 363 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1852 st056254 31.4 µM 0.437333687782794 0.324480002697163 no 1079 0.330934683787638 376 442583 SGTC_1219 1469-0211 33.1 µM 0.436800635960472 0.324681968055166 no 1080 0.331127968878224 395 6822282 SGTC_1896 st058441 89 µM 0.436560126311527 0.324773110444749 no 1081 0.331215192640443 341 688759 SGTC_1424 4048-1941 275 µM 0.43567920400346 0.325107030116968 no 1082 0.331534748053448 389 X1424 SGTC_1205 4161-2785 76 µM 0.434391010775605 0.325595581569228 no 1083 0.332002262175302 336 3498106 SGTC_3104 9120930 49.47 µM 0.433796451805659 0.325821171138344 no 1084 0.332218129217933 377 17014836 SGTC_519 k048-0011 62.8 µM 0.431322232116838 0.326760632190989 no 1085 0.333117043620007 349 6836379 SGTC_902 1120-0002 2.07 µM 0.431105927411002 0.326842815414679 no 1086 0.333195675464429 347 3280475 SGTC_903 1134-0042 114 µM 0.431025334090004 0.326873438343527 no 1087 0.333224974906023 366 701009 SGTC_1975 st070967 30.8 µM 0.430785012086613 0.326964760073187 no 1088 0.333312349236302 388 261391 SGTC_2489 cantharidin 73.42 µM 0.430584904603818 0.327040808298267 no 1089 0.333385109598741 363 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1942 st076330 65.2 µM 0.429613208896095 0.327410190582574 no 1090 0.333738513476651 377 24208414 SGTC_2625 euphol 100 µM 0.426953416858437 0.328422152851745 no 1091 0.334706628731811 373 6708538 A triterpene alcohol. SGTC_2375 9072683 200 µM 0.426489919033319 0.328598627459474 no 1092 0.33487544609869 383 16798029 SGTC_2026 5148700 152 µM 0.424882736288445 0.329210850653478 no 1093 0.335461080104619 347 79838 SGTC_1181 1222-0449 220 µM 0.421250686913417 0.330596091228936 no 1094 0.33678601768526 363 658318 SGTC_2041 5107442 45.335 µM 0.420753516781388 0.330785889994503 no 1095 0.336967538868494 368 793005 SGTC_1545 lovastatin 49.4 µM 0.420725241893203 0.330796685472459 no 1096 0.33697786342022 345 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1129 3453-1384 223 µM 0.420708229231534 0.330803181050095 no 1097 0.336984075638555 390 1084452 SGTC_43 0570-0105 72.5 µM 0.418892084354243 0.331496893138824 no 1098 0.337647501163673 363 1114046 YDL195W SEC31 SGTC_2638 epoxomicin 18 µM 0.418520038285806 0.331639074880539 no 1099 0.337783469463035 392 9915668 A protesome inhibitor. SGTC_1570 verbenone 133 µM 0.417889754198812 0.331880000644739 no 1100 0.33801386197658 390 29025 A natural terpanoid with antifungal properties. SGTC_67 0335-0847 266 µM 0.417166091886696 0.332156705939169 no 1101 0.338278462579257 391 4552207 YOR254C SEC63 SGTC_2252 omeprazole 400 µM 0.416830193943214 0.332285173670652 no 1102 0.33840130778974 375 4594 A proton pump inhibitor. SGTC_2046 4110841 106 µM 0.416587075097123 0.332378169348233 no 1103 0.338490232390132 378 44119630 YMR134W ERG29 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.411638476023085 0.334273299800098 no 1104 0.340302212892272 367 616764 SGTC_1785 bathophenanthroline 24 µM 0.405833301479442 0.336501860400795 no 1105 0.342432544104533 358 72812 An iron chelator. SGTC_689 0833-0039 98 µM 0.405515341502003 0.336624089673648 no 1106 0.342549371915946 415 5374726 SGTC_2231 micatex 6.853 µM 0.40545975394614 0.336645460257366 no 1107 0.342569797959916 380 20737 An antifungal of unknown mechanism. SGTC_3015 9080845 49.47 µM 0.405343691186475 0.336690082177095 no 1108 0.342612447533011 387 5296973 SGTC_1705 st027868 56.3335 µM 0.405231338216534 0.336733280007556 no 1109 0.342653735781307 405 292948 SGTC_895 0964-0006 13.7 µM 0.404976188337485 0.336831388852081 no 1110 0.342747507009051 383 6738897 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.40422610142684 0.337119872475683 no 1111 0.34302323076621 373 229346 A bile salt which induces apoptosis. SGTC_645 0845-0943 5.41 µM 0.403822508021891 0.337275134262604 no 1112 0.343171621900875 364 1885106 SGTC_3192 9110362 49.47 µM 0.403004644043433 0.337589850296341 no 1113 0.343472404043509 381 16649480 SGTC_580 1123-0028 41 µM 0.402516940713288 0.337777573808724 no 1114 0.343651811699009 377 1677248 YPR107C YTH1 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.402030666098414 0.337964787576186 no 1115 0.343830728852239 417 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_320 4092-0846 5.34 µM 0.401696140221905 0.33809360196767 no 1116 0.343953832738277 371 1359356 SGTC_432 NS 1619 61.3 µM 0.400903636452067 0.338398843502136 no 1117 0.344245536247569 346 4552 A K+/calcium channel activator. SGTC_2725 haloperidol 53.21 µM 0.400903578783315 0.338398865717756 no 1118 0.344245557477565 363 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_702 1488-0190 94 µM 0.400759698448218 0.33845429420947 no 1119 0.344298526666975 361 949357 SGTC_581 0958-0271 211 µM 0.398272400506262 0.339413053781163 no 1120 0.345214701259438 349 4591145 SGTC_2583 asiatic acid 100 µM 0.398126630148903 0.339469275090079 no 1121 0.345268422718278 402 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_255 tunicamycin 200.472 nM 0.398080736193909 0.339486976398339 no 1122 0.345285336886117 350 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1423 4048-0112 5.59 µM 0.397983970719397 0.339524300023006 no 1123 0.345321000710473 385 X1423 SGTC_3327 9140648 26.9345 µM 0.397820067330047 0.339587523151699 no 1124 0.345381411977178 409 8029710 SGTC_1699 st031318 29.054 µM 0.394568999240327 0.340842501803314 no 1125 0.346580498009382 395 5340658 SGTC_1465 k213-0056 144 µM 0.391802320157881 0.34191188611828 no 1126 0.347602140308264 352 24048857 YMR208W ERG12 SGTC_2722 naftopidil 47.16 µM 0.391725037101391 0.341941776041476 no 1127 0.347630694302132 397 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2714 st079313 56.9 µM 0.39146917776072 0.342040739030749 no 1128 0.34772523355856 363 2939799 SGTC_2220 6782180 200 µM 0.39014906619383 0.342551512935779 no 1129 0.348213161167612 385 833803 SGTC_247 mechlorethamine 29.705 µM 0.390015142274237 0.342603346515694 no 1130 0.348262674962563 375 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2356 9061756 188.97 µM 0.389896557526013 0.34264924573516 no 1131 0.348306519781768 374 20104043 SGTC_1283 0922-0125 16.4 µM 0.389088785828804 0.342961962314281 no 1132 0.348605234392588 382 3360884 SGTC_3261 9137475 49.47 µM 0.388983872525295 0.343002585810749 no 1133 0.348644038308299 371 17027690 SGTC_595 3909-8003 73.7 µM 0.388304792338579 0.343265576428203 no 1134 0.348895245599038 384 699517 SGTC_315 k915-0449 187 µM 0.388222589544064 0.343297416649647 no 1135 0.348925658789701 388 20970215 YNL149C PGA2 SGTC_109 0132-0036 33.701 µM 0.385145721682464 0.344490001087895 no 1136 0.350064727450986 398 67274 A color developer. SGTC_1404 3909-7820 48.3 µM 0.382062903141163 0.345686444357444 no 1137 0.351207353636086 376 23741373 SGTC_844 0330-0132 15.3 µM 0.381754471995459 0.345806231724375 no 1138 0.351321745844509 400 2828079 SGTC_2956 9076196 2.52 µM 0.37982612857753 0.346555504269574 no 1139 0.352037242760405 396 16423868 SGTC_875 0709-0210 25.7 µM 0.37836211812075 0.347124758058223 no 1140 0.352580802735509 395 6251364 SGTC_536 3852-0578 10.6 µM 0.377998869790893 0.347266054040917 no 1141 0.352715716787496 376 2869208 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.377960652964255 0.347280920819709 no 1142 0.352729911975344 354 6857784 SGTC_1240 0356-0016 42.1 µM 0.377715285512277 0.347376377136764 no 1143 0.35282105569432 382 4305613 SGTC_3356 9151811 4.48 µM 0.377426930921196 0.347488569292164 no 1144 0.35292817812955 384 1859254 YPR165W RHO1 SGTC_488 nitrendipine 139 µM 0.37561709129055 0.348193041130019 no 1145 0.353600791350585 381 4507 Dihydropyridine L-type calcium channel blocker. SGTC_864 0469-0573 172 µM 0.375021960206651 0.348424807828123 no 1146 0.353822067346195 393 689425 SGTC_1646 st011709 75.6 µM 0.373249731246561 0.349115316200127 no 1147 0.354481292984909 371 5757843 SGTC_294 k038-0071 157 µM 0.373010438986225 0.349208589293554 no 1148 0.354570337292682 384 24152826 SGTC_475 α-linolenic acid 10 µM 0.372159603134495 0.349540308075702 no 1149 0.354887010662371 373 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_889 0919-1524 82.7 µM 0.371556566386861 0.349775486039667 no 1150 0.355111516199772 370 3905452 SGTC_3088 9117578 49.47 µM 0.3703779065311 0.350235317335335 no 1151 0.355550466602215 377 678341 SGTC_938 3126-1755 342 µM 0.368930409459538 0.350800330711248 no 1152 0.356089798139871 385 1777771 SGTC_3245 9134821 49.47 µM 0.368858597164537 0.350828370397298 no 1153 0.356116562618666 393 17014901 SGTC_2838 9002687 71.43 µM 0.36634271195876 0.351811229803038 no 1154 0.357054680964369 394 6457060 SGTC_818 4072-2707 53.5 µM 0.365515263542066 0.352134698939143 no 1155 0.357363407596304 382 882871 SGTC_2478 5763493 32.33 µM 0.365315538228732 0.352212792324654 no 1156 0.35743794046711 396 1365576 YLR208W SEC13 SGTC_865 0488-0499 301 µM 0.3645716524259 0.352503709418779 no 1157 0.357715589283621 384 9634651 SGTC_1884 5633444 25 µM 0.363765319450013 0.35281914567421 no 1158 0.358016631009362 369 5724239 SGTC_2993 9054257 71.4286 µM 0.363393086971263 0.352964796619457 no 1159 0.358155632567853 389 6470217 YGL055W OLE1 SGTC_1786 berberine 21.6 µM 0.3623043336236 0.35339093882444 no 1160 0.358562310045695 417 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1330 1469-0054 61.8 µM 0.360698743507068 0.354019708284086 no 1161 0.35916233205341 410 7102664 SGTC_92 0063-0024 660.874 µM 0.360653451764217 0.354037450889139 no 1162 0.359179262991116 414 3594437 SGTC_2451 5856223 45.7 µM 0.360507299164039 0.354094706927147 no 1163 0.359233899572384 368 2179896 SGTC_406 estrone 100 µM 0.360407009325663 0.354133997899375 no 1164 0.359271392831651 406 5870 A steroid. SGTC_3219 9131112 49.47 µM 0.360393363553108 0.354139344081181 no 1165 0.359276494395298 366 17612988 YMR079W SEC14 SGTC_1156 4092-0367 4.88 µM 0.359893089743936 0.354335362699107 no 1166 0.359463542429778 382 1357585 SGTC_1614 st002383 48.6 µM 0.359753317160075 0.354390135665734 no 1167 0.359515808206812 378 1947235 SGTC_2322 7413319 38.22 µM 0.35914059320039 0.354630280576064 no 1168 0.359744957773599 388 1840400 SGTC_270 tamoxifen 5.46 µM 0.358016841326552 0.355070862791939 no 1169 0.360165355119611 410 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1932 st074806 40.9 µM 0.357878450945967 0.355125134041676 no 1170 0.360217138887748 431 17251235 SGTC_999 SEC7.066 22.7 µM 0.356533361197128 0.355652778154274 no 1171 0.360720586363744 388 740511 YDR170C SEC7 SGTC_478 N-arachidonylglycine 10 µM 0.355999388719029 0.355862318609717 no 1172 0.360920511482446 380 5283389 SGTC_767 0929-0023 86 µM 0.355668146527644 0.355992325928024 no 1173 0.361044551276208 391 1204563 SGTC_318 1488-0629 67.2 µM 0.35492614819285 0.356283609284944 no 1174 0.361322459356961 411 3662576 SGTC_1982 st072467 71.9 µM 0.353671000047048 0.356776528706647 no 1175 0.361792729150418 393 3163533 SGTC_609 0986-0026 86.3 µM 0.352598376609099 0.357197957002803 no 1176 0.362194777401355 400 2848610 SGTC_1405 3909-7894 12 µM 0.351523544963196 0.357620427704038 no 1177 0.362597805903514 387 7104060 SGTC_2000 st075254 36.4 µM 0.351219884569034 0.357739815355019 no 1178 0.362711696735445 373 17234175 SGTC_843 0310-0051 143 µM 0.348233149551758 0.358914825392865 no 1179 0.363832547093518 417 2065037 SGTC_620 0109-0052 432 µM 0.347517271952458 0.359196657406164 no 1180 0.364101372485538 396 493037 SGTC_3155 9099265 49.47 µM 0.347369966440071 0.359254659247229 no 1181 0.364156696754779 416 25236499 SGTC_3123 9126162 49.47 µM 0.347162065216797 0.359336526290615 no 1182 0.364234784075827 355 25239884 SGTC_2898 9056270 58.44 µM 0.34608609209147 0.359760324558723 no 1183 0.364639007624146 391 19154699 SGTC_2389 9091542 195.52 µM 0.345213135618524 0.360104286539572 no 1184 0.364967072147469 382 3626624 YOL127W RPL25 SGTC_1152 3909-8331 15.9 µM 0.344949803236321 0.360208066920172 no 1185 0.365066054135933 417 16001939 SGTC_1375 2910-0797 186 µM 0.344893883063541 0.360230106617905 no 1186 0.365087074698225 419 742508 SGTC_968 1309-0633 340 µM 0.343534832179025 0.360765889100424 no 1187 0.365598070560584 403 3761976 SGTC_1672 st016598 6.51 µM 0.343006103935833 0.360974405063958 no 1188 0.365796934074816 415 4665860 YNL267W PIK1 SGTC_361 000s-0510 1.45 µM 0.342150618019215 0.361311872823679 no 1189 0.36611877297302 369 660 SGTC_2125 5246583 200 µM 0.34159727028783 0.361530212149088 no 1190 0.36632699587949 425 835267 SGTC_3061 glucosamine 200 µM 0.339894400189846 0.36220241138378 no 1191 0.366968026930523 414 91431 and experimental redox chemotherapeutic SGTC_206 4546-0025 72.014 µM 0.339506432520372 0.362355619173807 no 1192 0.367114126048974 422 6620745 YIL048W NEO1 SGTC_1871 st057448 67.3 µM 0.339501655110792 0.362357505902412 no 1193 0.367115925224357 426 691747 SGTC_575 k072-0246 11.9 µM 0.339259856257142 0.362453003193245 no 1194 0.367206990631965 399 6796779 SGTC_2005 4024620 188 µM 0.338940628731129 0.362579093673114 no 1195 0.367327228386696 411 236743 SGTC_611 3453-1652 23.7 µM 0.336700716884944 0.363464246557507 no 1196 0.368171261449534 398 1560575 SGTC_2545 solidagenone 89.61 µM 0.334577398207919 0.364303998608357 no 1197 0.368971948417386 396 6708572 An anti ulcer agent SGTC_2773 thioridazine 9.09 µM 0.333548585506583 0.364711118786374 no 1198 0.36936011053666 404 5452 An antipsychotic. SGTC_2353 9059630 146.67 µM 0.333269858994058 0.364821442305889 no 1199 0.369465294586193 402 4779114 SGTC_2192 5915882 198.485 µM 0.332227821324316 0.365233993231367 no 1200 0.369858618666665 386 2876149 SGTC_1795 st049545 62.3 µM 0.330361791944618 0.365973158532031 no 1201 0.370563303980081 380 5291882 SGTC_314 1671-0008 2.74 µM 0.330038891990036 0.366101115172343 no 1202 0.370685287733493 403 3913060 SGTC_2716 st080858 38.6235 µM 0.328100682091419 0.366869488592919 no 1203 0.371417769140946 393 5296050 SGTC_654 1124-0271 80.9 µM 0.327480559212708 0.367115439584377 no 1204 0.371652222285254 408 5403748 SGTC_2124 5246320 200 µM 0.327298531996816 0.367187644948644 no 1205 0.371721051323405 408 579342 SGTC_1501 4491-0275 38.4 µM 0.327238377010713 0.367211507867495 no 1206 0.371743798328203 428 5104718 SGTC_1408 3909-7976 48.8 µM 0.327007956801493 0.367302918148128 no 1207 0.371830933561738 400 24152374 SGTC_2558 carylophyllene oxide 100 µM 0.326713696029836 0.367419665630454 no 1208 0.37194222015735 432 6708694 An oxygenated terpenoid and antifungal agent. SGTC_3161 9100388 49.47 µM 0.326226847084993 0.367612849065288 no 1209 0.37212636523989 402 25236368 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.322725250752647 0.369003279563286 no 1210 0.373451663605938 405 17037758 SGTC_763 3453-1109 128 µM 0.322342868695209 0.369155221897861 no 1211 0.373596480133006 425 1560353 SGTC_3008 9078912 71.4286 µM 0.321534170439294 0.369476631441556 no 1212 0.373902810791123 422 16648731 SGTC_2307 7538926 6.34 µM 0.320718371935865 0.369800955360076 no 1213 0.374211911701165 388 96582 SGTC_2706 st078239 82.5 µM 0.320600393808892 0.369847865703013 no 1214 0.374256619568493 421 15434492 SGTC_2726 cimetidine 79.27 µM 0.320191187236277 0.370010589009774 no 1215 0.374411701695042 430 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1988 st071872 53.4 µM 0.320108572770549 0.370043443943643 no 1216 0.37444301359729 411 16414116 SGTC_2150 5556613 200 µM 0.319620628552802 0.370237513738431 no 1217 0.374627967360998 415 743190 SGTC_710 3448-4187 58 µM 0.318498844599276 0.370683805490054 no 1218 0.375053285467442 395 3946412 SGTC_1955 wogonin 32.4 µM 0.315737229401622 0.371783230071548 no 1219 0.37610098305355 366 5281703 A flavanone. SGTC_2072 5231554 129 µM 0.315166706384481 0.37201049128973 no 1220 0.376317541397153 425 789545 SGTC_2193 5925765 200 µM 0.314667822324573 0.372209252512538 no 1221 0.376506939040822 388 877370 SGTC_679 0422-0091 41.4 µM 0.314308699340922 0.372352352375275 no 1222 0.376643295834252 430 627384 YHR062C RPP1 SGTC_1804 st050076 49.1 µM 0.314251616605961 0.37237509977696 no 1223 0.376664971216627 394 3895976 SGTC_3333 9141820 12.094 µM 0.313941866514895 0.372498542579882 no 1224 0.376782595898836 430 1939433 SGTC_1167 k781-0610 148 µM 0.313921901299493 0.372506499644151 no 1225 0.376790177894023 392 4525169 SGTC_1648 st011736 69.8 µM 0.313430551250225 0.372702342567818 no 1226 0.376976788080222 400 2855514 SGTC_836 0330-0104 1.35 µM 0.313222907790381 0.372785115256498 no 1227 0.377055657779852 376 46494820 SGTC_2811 7967822 32.47 µM 0.313105974564623 0.372831730808015 no 1228 0.377100075057703 384 2232244 SGTC_3319 9138450 16.7555 µM 0.313098919547186 0.372834543357596 no 1229 0.377102754969688 417 2029690 SGTC_210 3551-0445 56.827 µM 0.311656792538065 0.373409603080214 no 1230 0.37765068402559 409 2865180 YOR207C RET1 SGTC_920 mycophenolic acid 780.421 nM 0.311295189067405 0.37355383964306 no 1231 0.377788112149055 392 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2376 9072922 81.32 µM 0.308726617856398 0.374578901277989 no 1232 0.3787647470737 413 17087968 SGTC_34 0469-0683 81.75 µM 0.308502292044872 0.374668467112462 no 1233 0.378850078220736 402 3690923 SGTC_1492 4158-0558 28.5 µM 0.307978807507794 0.37487750336794 no 1234 0.379049229121069 416 3967268 SGTC_3169 9102970 49.47 µM 0.305450506814628 0.375887613285497 no 1235 0.38001152981966 406 17027839 SGTC_584 0986-0246 15.4 µM 0.303770304604478 0.376559360994481 no 1236 0.380651445897119 443 53315 YDR232W HEM1 SGTC_86 0417-1630 471.922 µM 0.303642966396978 0.376610286297719 no 1237 0.380699956830543 406 3634867 SGTC_985 1493-0307 8.71 µM 0.303112610150124 0.376822410319208 no 1238 0.380902022220882 446 3278274 SGTC_2175 5807670 165.306 µM 0.302252326397395 0.377166572913565 no 1239 0.381229858842789 395 241186 SGTC_3114 9122766 49.47 µM 0.301553550020317 0.377446195188556 no 1240 0.38149621105233 384 17176985 SGTC_2081 5214970 32.255 µM 0.300200321321798 0.377987885619953 no 1241 0.382012179995887 407 2063512 SGTC_2226 7298446 200 µM 0.300124767423967 0.378018136536407 no 1242 0.382040993926447 429 3283010 SGTC_2472 5377652 49.4 µM 0.298947083786453 0.378489764175457 no 1243 0.382490210580899 425 1610903 SGTC_3044 9093193 49.47 µM 0.296141036218929 0.379614232115079 no 1244 0.383561188171623 430 25236277 SGTC_2564 betulinic acid 100 µM 0.294739893161578 0.380176094441065 no 1245 0.384096292915166 400 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2363 9053361 176 µM 0.294705066690254 0.38019006318115 no 1246 0.384109596167803 433 6469797 YMR079W SEC14 SGTC_22 0964-0034 14.468 µM 0.293815857973507 0.380546773659906 no 1247 0.384449308375699 437 138402 SGTC_799 1310-0557 151 µM 0.292328793799525 0.381143543683152 no 1248 0.385017622777953 433 5354492 SGTC_2374 9071832 200 µM 0.291937539442515 0.381300604040501 no 1249 0.385167190375084 415 17381698 SGTC_2753 fluvastatin 17.09 µM 0.291433394526117 0.381503010626174 no 1250 0.385359938639979 412 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.291038044067553 0.381661760553531 no 1251 0.385511111650678 378 2724 A muscle relaxant with antifungal properties. SGTC_876 0720-0963 56.8 µM 0.290992247130338 0.381680151247467 no 1252 0.385528624481027 432 765861 SGTC_1354 1498-1681 81 µM 0.290950710987692 0.381696831163433 no 1253 0.385544508177772 407 5754243 SGTC_1839 st053978 48 µM 0.290835742601809 0.381743000847674 no 1254 0.385588473852815 413 3788398 SGTC_1731 st035964 63 µM 0.290528644511165 0.381866335361845 no 1255 0.385705920081946 418 6739575 SGTC_762 1165-0429 115 µM 0.289246579881755 0.382381358284458 no 1256 0.386196344433242 442 5967793 SGTC_2402 5553605 200 µM 0.288859478653402 0.382536903100739 no 1257 0.386344456895453 404 6758546 SGTC_1941 st076221 61.8 µM 0.287660951360357 0.383018614795908 no 1258 0.386803141694763 389 2828568 SGTC_1050 3232-1156 69.3 µM 0.287212114709616 0.383199057690796 no 1259 0.386974955367842 425 700529 SGTC_2180 6301957 200 µM 0.287167841475057 0.383216857946743 no 1260 0.386991904264425 430 845462 SGTC_3149 9097855 49.47 µM 0.285174079616079 0.384018714025503 no 1261 0.387755388838319 449 25236625 YMR079W SEC14 SGTC_3020 9089140 49.47 µM 0.283666992126413 0.384625168073616 no 1262 0.388332796254741 392 17217859 SGTC_871 0574-0004 149 µM 0.283560522216355 0.384668022408596 no 1263 0.388373597210039 408 9551173 SGTC_2694 st077685 81.9 µM 0.283098950209956 0.384853822283208 no 1264 0.388550493151361 379 2838096 SGTC_2009 4012297 12.05 µM 0.282574159612708 0.38506510211361 no 1265 0.388751645488755 395 45595307 SGTC_2008 4012253 172 µM 0.282000367123417 0.385296149079136 no 1266 0.388971614398865 419 603940 SGTC_171 k064-0041 9.68 µM 0.281845002621683 0.385358716155254 no 1267 0.389031181012667 388 53325 SGTC_1222 0366-0074 1.18 µM 0.281196199038903 0.385620029069864 no 1268 0.38927995991293 438 286520 SGTC_3079 9117512 49.47 µM 0.280107303467692 0.386058710611996 no 1269 0.389697590777259 460 7185044 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.280031100500577 0.386089415836504 no 1270 0.38972682214844 402 5355888 SGTC_1698 5-fluorocytosine 1.055 µM 0.279778860951821 0.386191058332341 no 1271 0.38982358540019 434 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2886 9058944 51.95 µM 0.278894968568584 0.386547293375257 no 1272 0.390162714953529 417 4949929 SGTC_1974 st069448 26.9 µM 0.276885870980846 0.387357375038041 no 1273 0.390933870969016 423 6323587 YNR016C ACC1 SGTC_784 4579-0127 173 µM 0.275768417203875 0.387808152530211 no 1274 0.391362971417084 462 1948547 SGTC_2090 5301565 104.445 µM 0.275223504698545 0.388028023492652 no 1275 0.391572264940345 418 2056344 SGTC_507 nimesulide 162 µM 0.275165174422238 0.388051561755417 no 1276 0.391594670671519 440 4495 A COX2 inhibitor. SGTC_2021 4019055 173 µM 0.274631636642881 0.388266881584625 no 1277 0.391799629018195 422 44827708 YER133W GLC7 SGTC_1207 2099-0101 141 µM 0.273676955733117 0.388652247811418 no 1278 0.392166444263079 423 5837381 SGTC_684 1140-0066 328 µM 0.273213587260272 0.388839330533076 no 1279 0.39234451802825 406 6813534 SGTC_2702 st077768 96.8 µM 0.2720308592374 0.389316967894222 no 1280 0.392799145757912 389 6484119 SGTC_1417 3966-0327 90.4 µM 0.271848072974565 0.389390799932 no 1281 0.392869419866809 433 651118 SGTC_62 0180-0423 3.232 µM 0.271820705526811 0.389401854686533 no 1282 0.3928799418717 434 30102 YGL099W LSG1 SGTC_2932 9016711 44.54 µM 0.271682816153848 0.389457554817651 no 1283 0.392932957602379 414 7117328 SGTC_1135 dihydrocapsaicin 536.708 nM 0.270480932250042 0.389943149420389 no 1284 0.393395142140433 430 107982 A Capsaicinoid. SGTC_931 2812-0076 566 µM 0.269987597140683 0.390142520337095 no 1285 0.393584897726821 414 3450959 SGTC_2078 5212016 200 µM 0.269767001464141 0.39023167875256 no 1286 0.393669755457254 459 1899708 SGTC_2350 9023895 38.85 µM 0.269695356878785 0.390260636671708 no 1287 0.393697316453473 429 2997209 SGTC_1065 prochlorperazine maleate 2.48 µM 0.269559044985731 0.390315734055626 no 1288 0.393749755823399 459 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_159 3970-0959 50 µM 0.268633677432961 0.390689826602141 no 1289 0.394105796868995 417 6615653 SGTC_1748 st037455 53.6035 µM 0.26761817554381 0.391100473647794 no 1290 0.394496619532869 433 580690 SGTC_520 3584-0023 682 µM 0.267235342088536 0.391255314778589 no 1291 0.394643983129224 385 1340790 SGTC_2715 st079500 56.4 µM 0.266568820695201 0.391524937677257 no 1292 0.394900582327101 433 28246688 SGTC_2210 7115885 190.385 µM 0.2660098179095 0.391751107074424 no 1293 0.395115823882387 445 2927039 SGTC_3284 9108171 64.8615 µM 0.26422932659048 0.392471727420105 no 1294 0.39580160724322 438 8687505 SGTC_1703 st026983 48.3 µM 0.263954763466624 0.392582884561696 no 1295 0.3959073881834 422 1104023 SGTC_651 3253-0966 34.4 µM 0.263767122310069 0.39265885630353 no 1296 0.395979685106002 418 781462 SGTC_1569 carminic acid 40.6 µM 0.263238694179509 0.392872827100332 no 1297 0.39618330426331 451 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1494 4358-1428 177 µM 0.262887157900184 0.393015188893409 no 1298 0.396318777394827 433 1564571 SGTC_1382 3002-2117 298 µM 0.261994053028182 0.393376934263227 no 1299 0.396663013547434 454 1497314 SGTC_2116 5511452 16.8835 µM 0.26194105748676 0.393398402602855 no 1300 0.396683442553411 448 870744 SGTC_1744 st037937 38.9 µM 0.261287147654039 0.393663326227141 no 1301 0.396935538549633 397 1016152 SGTC_2343 7990716 14.84 µM 0.260548502486202 0.393962638549641 no 1302 0.397220353605759 427 6456862 SGTC_900 1112-0045 141 µM 0.260330231489626 0.394051097886827 no 1303 0.397304527474648 440 56211 YIL048W NEO1 SGTC_1007 4101-0031 70 µM 0.259291436548759 0.39447216824464 no 1304 0.397705193088889 442 1146276 SGTC_1282 0886-0010 32.4 µM 0.256006780423657 0.395804396619393 no 1305 0.398972800862893 454 2836211 YNL267W PIK1 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.255172780389525 0.396142854421452 no 1306 0.399294826710716 412 6708739 YPR165W RHO1 SGTC_2294 7971431 200 µM 0.252933302734374 0.397052076494534 no 1307 0.400159877071107 453 5741572 SGTC_650 1328-0195 38 µM 0.252466582008198 0.397241634547078 no 1308 0.400340220665647 445 2780821 SGTC_707 0865-0008 204 µM 0.251589017251403 0.397598122100314 no 1309 0.400679374292196 454 723043 SGTC_711 k292-0785 179 µM 0.250732674684835 0.397946071161834 no 1310 0.401010398346241 449 4146315 SGTC_1816 st051957 91.6 µM 0.250503531030263 0.398039190578003 no 1311 0.401098987184213 457 674121 SGTC_3262 9137218 49.47 µM 0.250296510166928 0.398123324726751 no 1312 0.401179027540192 430 17650664 SGTC_3041 9091929 49.47 µM 0.249964983118512 0.398258068577849 no 1313 0.40130721428796 416 25236887 SGTC_793 0488-0545 106 µM 0.248809092204492 0.398727956695938 no 1314 0.401754228839139 448 292548 SGTC_3075 9116269 49.47 µM 0.24813305586183 0.399002844363027 no 1315 0.402015730163389 448 17015205 YNL244C SUI1 SGTC_411 enrofloxacin 100 µM 0.247222037403916 0.399373358903491 no 1316 0.402368195580162 453 71188 A bacterial gyrase inhibitor. SGTC_29 0299-0004 12.984 µM 0.246850965643001 0.399524301148413 no 1317 0.402511782909141 456 16871 A napthoquinone isolated from Swertia calycina. SGTC_636 0kpi-0074 126 µM 0.246452798989405 0.399686281587725 no 1318 0.402665869316273 429 616434 SGTC_319 1348-1596 45.5 µM 0.246436783482879 0.399692797308352 no 1319 0.40267206746937 441 5380505 SGTC_2581 avocatin a 64 µM 0.246106209529925 0.399827293672569 no 1320 0.402800008189493 436 6710728 A skin care supplement. SGTC_1658 st012944 20 µM 0.245833559030476 0.399938232412456 no 1321 0.402905538859867 449 24207260 SGTC_1519 esterone 74 µM 0.245481243948833 0.400081597827862 no 1322 0.403041914559725 418 698 A steroid. SGTC_1565 sinapyl alcohol 95.1 µM 0.243937526838606 0.400709931702844 no 1323 0.403639602349436 455 5280507 A phenol propionate derived from cinnamic acid. SGTC_1757 st041620 31.8375 µM 0.241492356686387 0.401705706233009 no 1324 0.404586769849802 435 5289815 SGTC_251 melphalan 456.522 µM 0.24131867056124 0.401776462779637 no 1325 0.404654070705174 447 460612 A DNA alkylator. SGTC_2533 agelasine 13.65 µM 0.240881140391444 0.401954718825331 no 1326 0.404823619801722 458 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1148 3909-7663 27.7 µM 0.24087230032473 0.401958320605222 no 1327 0.404827045636226 437 4084526 SGTC_3218 9131285 49.47 µM 0.239573442773867 0.402487614975433 no 1328 0.4053304774289 451 17156417 SGTC_1984 st072354 53.1 µM 0.239451519455625 0.402537308853758 no 1329 0.405377742457077 447 5762938 SGTC_3055 9094636 49.47 µM 0.238843718291225 0.402785061787633 no 1330 0.405613384398774 453 25236176 SGTC_1970 st070122 35.8 µM 0.235753640826433 0.404045246182708 no 1331 0.406811921726514 461 102928 SGTC_1140 3229-1848 2.98 µM 0.233378351702305 0.405014606268543 no 1332 0.407733810967151 451 2849525 SGTC_223 busulfan 5 mM 0.233103950647982 0.405126627553381 no 1333 0.407840343614351 443 2478 A DNA alkylator. SGTC_1331 1472-0049 76.2 µM 0.230161828713113 0.406328203966704 no 1334 0.408983010947409 464 24051409 SGTC_747 3448-8087 38.7 µM 0.229895075182271 0.406437191173124 no 1335 0.409086651640821 443 5168703 SGTC_2803 7707263 71.43 µM 0.227946810501146 0.407233410894118 no 1336 0.409843795494097 441 2199229 SGTC_282 k297-0036 65.7 µM 0.227262371589343 0.407513219604427 no 1337 0.410109865357617 433 5061378 SGTC_3335 9143315 29.6265 µM 0.225921899502621 0.40806136094015 no 1338 0.410631082394359 412 4899691 SGTC_2258 7960471 200 µM 0.22580366168557 0.408109719003844 no 1339 0.410677064506917 467 2974708 SGTC_1493 4348-0038 111 µM 0.224561011888735 0.408618034641451 no 1340 0.411160399110503 461 800424 SGTC_1287 0971-0001 34.6 µM 0.222172247149497 0.409595608792228 no 1341 0.412089898900394 425 4665869 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.221969446851224 0.40967862843426 no 1342 0.412168833959448 452 5282309 SGTC_2515 chrysin 20.77 µM 0.221239528764372 0.409977465917952 no 1343 0.412452966121494 418 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2263 7948595 193.29 µM 0.221059082342572 0.41005135098123 no 1344 0.412523214825477 443 2971371 SGTC_552 k242-0005 476 µM 0.219116353319016 0.410847016867608 no 1345 0.41327970609468 468 4088318 SGTC_2910 7948405 25.97 µM 0.218991844760975 0.410898023255119 no 1346 0.413328200263968 462 2971328 SGTC_3152 9099253 49.47 µM 0.217688240584617 0.411432150265699 no 1347 0.413836013311369 457 25236131 SGTC_376 3970-0862 59.1 µM 0.217342855773488 0.411573692675882 no 1348 0.413970580570942 455 3135186 SGTC_2807 7945238 51.95 µM 0.217335926971837 0.41157653229113 no 1349 0.413973280242547 466 17148797 SGTC_1473 k844-0725 134 µM 0.215659384128036 0.412263761888565 no 1350 0.414626631474365 448 54682906 SGTC_474 dl-dihydrosphingosine 5 µM 0.214656317423913 0.412675056523346 no 1351 0.415017641134849 420 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1549 4'-methoxyflavonol 74.6 µM 0.214652679575133 0.412676548351365 no 1352 0.415019059373481 461 97141 SGTC_2126 5251174 33.877 µM 0.214640644776763 0.412681483653301 no 1353 0.415023751224553 416 790722 SGTC_156 3474-0145 5.642 µM 0.213411989791171 0.413185410329812 no 1354 0.415502814705611 456 2265471 SGTC_1178 0988-0033 191 µM 0.212637499209993 0.413503137323241 no 1355 0.415804860055311 445 5392207 SGTC_373 0844-0104 25.9 µM 0.212373739092813 0.413611355207124 no 1356 0.415907735829857 447 5375804 SGTC_1019 4262-0212 3.4 µM 0.211243195837358 0.414075278952276 no 1357 0.41634875288818 444 4677213 SGTC_777 1315-0167 517 µM 0.211178234032028 0.41410193998447 no 1358 0.416374097241853 435 4221767 SGTC_96 0929-0093 37.281 µM 0.210095559845687 0.414546339444737 no 1359 0.416796545438185 406 6991579 SGTC_1630 st005209 31.3 µM 0.210073551390331 0.414555374273718 no 1360 0.416805133906591 465 3367314 SGTC_2211 7117706 200 µM 0.209757600945484 0.414685082051914 no 1361 0.416928433186432 464 822771 SGTC_2647 atorvastatin 60.16 µM 0.208421349859764 0.415233758632351 no 1362 0.417449993783922 462 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2117 5521686 200 µM 0.207903211318466 0.415446555473388 no 1363 0.417652270845442 433 803312 SGTC_2560 caryophyllene 100 µM 0.205757027044412 0.41632824580109 no 1364 0.418490355170605 427 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3243 9134147 49.47 µM 0.204776407239702 0.416731242161849 no 1365 0.418873410346567 461 24282180 SGTC_3339 9145883 14.936 µM 0.204265750923734 0.416941136606021 no 1366 0.419072916247185 465 2030670 SGTC_2926 9010726 65.15 µM 0.203809991146529 0.417128486990968 no 1367 0.419250992456061 431 2994293 SGTC_1384 3089-0840 101 µM 0.203759171952544 0.417149378539303 no 1368 0.419270849752263 429 1069836 SGTC_2865 9030313 51.95 µM 0.203699724301299 0.417173817505544 no 1369 0.419294078827498 459 42562754 SGTC_1851 st056236 18.9 µM 0.203283524688699 0.417344926382021 no 1370 0.419456716038749 448 5393171 SGTC_1297 1068-0111 14.1 µM 0.20321774867907 0.417371969789335 no 1371 0.419482420414305 461 767057 SGTC_1449 4112-4002 201 µM 0.203192288766127 0.417382437583017 no 1372 0.419492369896417 424 2059539 SGTC_2947 9072639 7.68 µM 0.202672142935212 0.417596307337219 no 1373 0.419695649000195 430 16488146 SGTC_2435 5706476 10.6 µM 0.200659009872959 0.418424281854567 no 1374 0.420482606565474 458 5725375 SGTC_2967 9089538 49.85 µM 0.200656005121415 0.418425517939562 no 1375 0.420483781396856 451 728216 SGTC_1241 0364-0022 50.8 µM 0.200087973750406 0.418659207309474 no 1376 0.420705889371225 461 4563895 SGTC_1966 st070145 16.1 µM 0.200013702902056 0.418689764625723 no 1377 0.420734932148504 470 3748532 SGTC_2539 epi(13)torulosol 80 µM 0.199025626741247 0.419096336224745 no 1378 0.42112134917277 443 6708597 SGTC_1597 7-benzyloxygramine 47.5 µM 0.198598195076115 0.4192722417508 no 1379 0.421288532804496 469 260807 SGTC_3232 9132874 49.47 µM 0.19843803893902 0.419338156677086 no 1380 0.421351179187144 463 3784940 SGTC_2895 9054447 58.44 µM 0.197142962179347 0.419871250099965 no 1381 0.421857832062365 443 2697450 SGTC_246 cycloheximide 667 µM 0.195493143494112 0.420550579099027 no 1382 0.422503452415216 456 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3287 9117173 37.0625 µM 0.195122314604555 0.420703304177289 no 1383 0.42264859689358 461 2789709 SGTC_1081 sertraline 6 µM 0.193745340792686 0.421270512146006 no 1384 0.423187643812064 485 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2892 9047358 58.44 µM 0.193491987547272 0.42137489215516 no 1385 0.423286840250671 454 6466771 SGTC_594 1487-1584 10.8 µM 0.193177351368721 0.421504528054586 no 1386 0.423410037817138 449 5013332 SGTC_2088 5278280 127.392 µM 0.192882950891368 0.421625834178003 no 1387 0.423525318762472 437 791502 SGTC_36 0335-0881 14.2 µM 0.192741201989902 0.421684243699216 no 1388 0.423580826943198 449 23828853 SGTC_2799 7812892 81.82 µM 0.191797698925884 0.42207307053713 no 1389 0.423950336746977 460 20205235 SGTC_2268 7933382 153.85 µM 0.191479511843187 0.422204215693766 no 1390 0.42407496537076 405 935025 YOR257W CDC31 SGTC_381 3461-2219 42.7 µM 0.191326637292438 0.422267228098782 no 1391 0.424134846508081 462 2883159 SGTC_506 n9-isopropylolomoucine 153 µM 0.190472424173984 0.422619357436969 no 1392 0.424469474966824 469 6610355 SGTC_2764 methyldopa 94.69 µM 0.188509640045415 0.423428703065851 no 1393 0.425238579661744 466 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_27 0485-0001 32.618 µM 0.187832745031289 0.423707892945482 no 1394 0.425503882891559 482 2054479 SGTC_308 4092-1169 104 µM 0.186473261394544 0.424268736648306 no 1395 0.426036822704751 461 2268590 YDL196W YDL196W SGTC_1020 4335-0961 93.3 µM 0.185368419071679 0.4247246432273 no 1396 0.426470038530996 459 669075 SGTC_2593 nobiletin 86.24 µM 0.18528554667785 0.424758844093215 no 1397 0.426502536916856 424 72344 An anti-infammatory. SGTC_2663 amphotericin b 100 µM 0.184979422415563 0.42488518437552 no 1398 0.426622587784504 456 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1631 benzylvanillin 81.9 µM 0.183670929718895 0.42542529809926 no 1399 0.42713580781015 426 75506 SGTC_1594 piperine 70.1 µM 0.183393283769319 0.425539921580638 no 1400 0.427244722638547 479 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1410 3909-8106 77.9 µM 0.182660912213386 0.425842304359505 no 1401 0.427532043610823 472 1039210 SGTC_700 3453-2283 142 µM 0.182216285859952 0.426025903711315 no 1402 0.427706496339983 442 565664 SGTC_3244 9134489 49.47 µM 0.181571631410731 0.426292129041371 no 1403 0.427959456796853 472 16584271 SGTC_1243 0416-0003 5.65 µM 0.181302565689768 0.426403256049574 no 1404 0.428065046136843 461 2141977 SGTC_3035 9091303 49.47 µM 0.180846795583688 0.426591507284772 no 1405 0.428243915543441 481 25237002 SGTC_2455 5377712 9.75 µM 0.180399742259474 0.426776174389248 no 1406 0.428419378326337 449 2243908 SGTC_3100 9120536 49.47 µM 0.178681481930485 0.427486095956031 no 1407 0.429093905224399 461 16421196 SGTC_577 r071-0003 38.6 µM 0.178015530500211 0.427761305715995 no 1408 0.429355389485431 474 4568517 YMR134W ERG29 SGTC_2873 9040596 71.43 µM 0.176958012279389 0.428198405761659 no 1409 0.42977068518082 483 6463863 SGTC_1813 st051246 8.6015 µM 0.176944690947446 0.428203912380963 no 1410 0.429775917068951 471 5291959 SGTC_1792 st045773 43.6 µM 0.176132682106872 0.428539597635242 no 1411 0.430094852832323 461 2919270 SGTC_2202 7226349 200 µM 0.175312202883128 0.428878837073859 no 1412 0.430417161873333 440 844334 SGTC_608 k048-0125 159 µM 0.174670057144546 0.429144378528115 no 1413 0.430669448484573 473 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2544 sphondin 68.51 µM 0.174644782535108 0.429154830794424 no 1414 0.430679378968115 485 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3266 9136860 49.47 µM 0.173692953857624 0.429548493817218 no 1415 0.431053387679956 472 4871271 YPR165W RHO1 SGTC_1036 k216-0215 33.5 µM 0.171967586810312 0.430262259841672 no 1416 0.431731505658988 456 622330 SGTC_2524 avocatin b 10.57 µM 0.171807424491853 0.430328528888973 no 1417 0.431794464210654 480 6710748 SGTC_2071 5230951 39.92 µM 0.171413979553847 0.430491329697805 no 1418 0.431949131683088 484 1799272 SGTC_2645 abamectin 100 µM 0.168984713322482 0.431496779307205 no 1419 0.432904332738547 469 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_803 4488-1585 147 µM 0.167343615662182 0.432176265329469 no 1420 0.433549843813066 478 747204 SGTC_3290 9121031 71.43 µM 0.166594402310591 0.432486539179572 no 1421 0.433844599228027 466 17014854 SGTC_3140 9094243 49.47 µM 0.16589407870727 0.432776603834038 no 1422 0.434120153717193 483 19291112 SGTC_906 1165-0455 526 µM 0.165471942141106 0.432951464654235 no 1423 0.434286266157082 481 3252859 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.16409994784002 0.433519873727816 no 1424 0.43482623143709 478 65057 A dermal irritant. YDR527W RBA50 SGTC_1936 st074407 74.3 µM 0.163903994516397 0.433601067274811 no 1425 0.434903361230236 464 809813 SGTC_2596 sinensetin 100 µM 0.163853750085927 0.433621886579755 no 1426 0.4349231384949 455 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2184 6075246 200 µM 0.163692435228233 0.433688730321779 no 1427 0.434986636516269 484 2267320 SGTC_1463 k081-0032 34.1 µM 0.163635793987297 0.433712201098982 no 1428 0.435008932484243 468 977755 SGTC_2141 5621638 7.665 µM 0.163597862151136 0.433727919276461 no 1429 0.435023863893488 478 2856238 SGTC_423 5-fluorouracil 457 µM 0.163447965100736 0.43379003457503 no 1430 0.43508286996361 447 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2485 5633444 17.78 µM 0.16252704773409 0.434171686029394 no 1431 0.43544541520838 460 5724239 SGTC_785 1270-0111 65.3 µM 0.162521941401497 0.434173802394208 no 1432 0.435447425612618 474 6741994 SGTC_1111 tnp00062 510.699 nM 0.162111430944157 0.43434394826032 no 1433 0.435609052337614 462 676306 SGTC_1458 k015-0034 6.33 µM 0.161858293493989 0.434448873188484 no 1434 0.435708723315373 476 3598957 SGTC_433 pimozide 108 µM 0.161682582592152 0.434521707694544 no 1435 0.435777910570385 450 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1438 4092-1045 4 µM 0.161559829501333 0.434572591802301 no 1436 0.435826246525942 471 1351342 SGTC_1856 st057054 55.7 µM 0.161241988034999 0.434704349767021 no 1437 0.435951406043095 481 1266018 SGTC_3256 9138902 49.47 µM 0.161185850695244 0.434727621687315 no 1438 0.435973512454752 489 17228773 SGTC_559 1550-0661 158 µM 0.160640520892915 0.43495370172151 no 1439 0.436188269138027 475 5830875 SGTC_2697 mebhydrolin 72.4 µM 0.160286548197192 0.435100461294867 no 1440 0.436327677428372 464 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3354 9151612 71.43 µM 0.158798596758623 0.435717473998382 no 1441 0.436913777203711 483 27261949 SGTC_1102 cgs 12066b 26.1 µM 0.157657572214093 0.436190731728807 no 1442 0.437363317371785 459 6438352 A 5-HT1B full agonist. SGTC_556 4058-0063 51.5 µM 0.157485345486039 0.436262173404149 no 1443 0.437431178194188 474 6615692 SGTC_2323 6148992 148.28 µM 0.156933907215253 0.43649093047032 no 1444 0.437648468423866 438 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1649 st011737 51.3 µM 0.15534390274896 0.437150642013161 no 1445 0.438275103145287 480 1761035 SGTC_3116 9124943 49.47 µM 0.155200190372354 0.4372102786082 no 1446 0.438331749105817 478 41905195 YPL160W CDC60 SGTC_1200 1643-0193 18.4 µM 0.154593617558903 0.437462004971928 no 1447 0.438570850977564 482 5403974 SGTC_1873 rapamycin 2 nM 0.150513199911427 0.439156022172399 no 1448 0.440179868672936 465 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2582 agaric acid 100 µM 0.150383664047616 0.439209818419113 no 1449 0.440230964451586 468 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_833 3852-0053 558 µM 0.149996961027771 0.439370422865873 no 1450 0.440383506441762 460 3123681 SGTC_3128 9127691 49.47 µM 0.149569186473078 0.439548096656322 no 1451 0.440552260147626 487 41316314 SGTC_2172 5754775 163.918 µM 0.149467722372006 0.43959024099644 no 1452 0.440592288524889 493 2263357 SGTC_1556 plumbagin 1.48 µM 0.148092955808142 0.440161334184768 no 1453 0.441134704299448 492 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3195 9113082 49.47 µM 0.14745188333451 0.440427685399999 no 1454 0.441387678022017 501 17018038 SGTC_2584 androsterone 48.74 µM 0.146008271486536 0.441027572222029 no 1455 0.441957429352882 477 2754130 A steroid. SGTC_2274 7947094 46.08 µM 0.1445119648293 0.441649498976442 no 1456 0.442548104527765 477 2971028 SGTC_396 dithiazanine 1.25 µM 0.144494930178171 0.441656580111225 no 1457 0.442554829786611 483 10578 An antihelmenthic. SGTC_1868 st057644 42.7 µM 0.143467443599538 0.442083730448467 no 1458 0.442960510738042 455 688665 SGTC_1474 0330-0125 5.35 µM 0.142366722622902 0.442541400758935 no 1459 0.443395173055713 488 X1474 SGTC_1087 pterostilbene 9.05 µM 0.141864654117343 0.442750182028674 no 1460 0.44359345690725 478 5281727 Similar to reservatol, lowers cholesterol. SGTC_2929 9013348 24.6 µM 0.141396816713673 0.442944742873036 no 1461 0.443778234450524 474 2995952 SGTC_1262 0737-0114 49.6 µM 0.140374878074643 0.443369787130615 no 1462 0.444181902847768 504 765919 SGTC_2313 7726885 200 µM 0.139520211846262 0.443725309583666 no 1463 0.444519542698102 456 726423 SGTC_1047 2043-3044 82 µM 0.139484220418873 0.443740282225991 no 1464 0.444533762163301 488 669592 SGTC_3144 9087057 49.47 µM 0.139161081559753 0.443874713458475 no 1465 0.444661430808397 502 17249618 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.138107827726564 0.444312929625507 no 1466 0.445077599715979 491 6708514 SGTC_2580 diallyl disulphide 81.36 µM 0.137232458355404 0.444677187119201 no 1467 0.445423527776919 486 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_685 1278-0033 54.9 µM 0.136493920518323 0.444984542817274 no 1468 0.445715415148439 499 3590572 SGTC_1296 1068-0102 11.9 µM 0.136486286747514 0.444987719920232 no 1469 0.445718432346553 492 767053 SGTC_652 0437-0092 114 µM 0.135998452069145 0.445190759403099 no 1470 0.445911252332832 460 3091274 SGTC_8 0354-0001 70 µM 0.135845975434747 0.445254223970963 no 1471 0.445971522389576 488 4993152 SGTC_2442 5158906 48.48 µM 0.135507912755221 0.445394939068717 no 1472 0.446105154244296 503 1893835 SGTC_1798 st045719 60.953 µM 0.135315805221354 0.445474904911649 no 1473 0.446181094624922 496 3980186 SGTC_761 k216-0224 480 µM 0.134846268886421 0.445670361386125 no 1474 0.446366711307491 501 1340404 SGTC_2756 carbadox 75.1 µM 0.13411187332038 0.445976098732418 no 1475 0.446657055455368 481 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_70 0141-0289 43.283 µM 0.132971684370006 0.446450836136584 no 1476 0.447107887103395 459 352408 SGTC_331 k048-0133 24.5 µM 0.132960825352378 0.446455357846617 no 1477 0.447112181097415 474 6813582 SGTC_631 k072-0230 41.5 µM 0.131012269968817 0.447266851170553 no 1478 0.447882800518969 472 5773147 SGTC_561 1550-0330 72.9 µM 0.130989368681958 0.447276389935845 no 1479 0.44789185875102 485 6812934 SGTC_2398 5228213 48.84 µM 0.130808367082607 0.447351781172507 no 1480 0.447963451949493 486 80771 YMR134W ERG29 SGTC_471 1-acyl-paf 4 µM 0.130606805525906 0.447435738332392 no 1481 0.448043179408467 476 16759367 SGTC_377 3970-0964 33.1 µM 0.129314176419428 0.447974217608958 no 1482 0.448554527228507 480 16481235 SGTC_2403 6032726 181.2 µM 0.129072507312658 0.448074902017254 no 1483 0.44865013799823 486 2881040 SGTC_3233 9132340 49.47 µM 0.128231927026181 0.448425131370904 no 1484 0.448982717259657 498 17682950 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.128208789921532 0.448434772058708 no 1485 0.448991872064192 486 23665772 A membrane-active detergent. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.128143451826788 0.448461997071797 no 1486 0.449017724948007 485 688751 SGTC_2669 eugenol 100 µM 0.127676203561672 0.448656696686261 no 1487 0.449202611375145 491 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1564 D-Arginine 115 µM 0.127285619640405 0.448819460209055 no 1488 0.449357170795866 481 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_485 niflumic acid 177 µM 0.126448950175565 0.449168144759012 no 1489 0.449688278221674 476 4488 A COX2 inhibitor. SGTC_69 0096-0274 206.684 µM 0.125289522326518 0.449651404692537 no 1490 0.450147173397189 494 6741392 SGTC_3298 9116858 71.43 µM 0.124111532028212 0.450142478105341 no 1491 0.450613483760246 489 2506942 SGTC_2427 5545055 42.75 µM 0.124074943558981 0.45015773210971 no 1492 0.450627968491003 476 5372858 SGTC_2136 5328288 199.296 µM 0.12401700759455 0.450181886193867 no 1493 0.450650904453735 490 262395 SGTC_574 1315-0397 40 µM 0.121415751943029 0.451266564556862 no 1494 0.451680870467664 500 6794277 SGTC_1206 3978-0017 132 µM 0.121216322652869 0.451349738226948 no 1495 0.451759847921158 491 3873677 SGTC_2429 5902844 64.44 µM 0.12085324194801 0.451501169583423 no 1496 0.451903639069652 502 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_202 3594-0513 34.79 µM 0.119701028470317 0.451981773974219 no 1497 0.452359992808668 500 708429 SGTC_2762 leflunomide 42.06 µM 0.118166788649811 0.452621836035874 no 1498 0.452967752183903 485 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2122 5258151 111.688 µM 0.117666102658264 0.452830741523103 no 1499 0.453166113154283 464 2173356 SGTC_492 tmb-8 126 µM 0.117191962218204 0.453028583221004 no 1500 0.453353968125154 501 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2345 9052315 157.45 µM 0.115039759913955 0.453926765453368 no 1501 0.454206803688342 481 6469265 SGTC_147 4466-0538 29.23 µM 0.114765214439178 0.454041359027434 no 1502 0.454315610842151 456 6742687 YHR072W ERG7 SGTC_387 norethindrone acetate 66.7 µM 0.113814240438365 0.454438319180398 no 1503 0.454692524856239 489 541197 SGTC_1560 lithocholic acid 53.1 µM 0.113545149742306 0.454550652594282 no 1504 0.454799185091419 510 9903 A bile acid which acts as a detergent. SGTC_3001 9076041 71.4286 µM 0.112309643143164 0.455066468247909 no 1505 0.455288948028548 475 16004211 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.111995988495848 0.45519742903635 no 1506 0.455413293638668 443 6708561 SGTC_2805 7950783 58.44 µM 0.111769851488975 0.455291851448678 no 1507 0.455502946365095 476 1178958 YDL195W SEC31 SGTC_3135 9127742 49.47 µM 0.111764499314229 0.455294086253946 no 1508 0.455505068279048 512 3643468 SGTC_1581 himbacine 57.9 µM 0.11134975518338 0.455467267327231 no 1509 0.455669500876007 485 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1781 st038725 66.3 µM 0.111203034337524 0.455528534293557 no 1510 0.455727672752809 461 4270275 YIL048W NEO1 SGTC_885 0865-0106 16.8 µM 0.110948133228585 0.45563497715395 no 1511 0.455828738193365 509 2793380 SGTC_3084 9116877 49.47 µM 0.109796418487042 0.456115955458456 no 1512 0.456285415752945 503 27241325 SGTC_618 k072-0232 33.2 µM 0.109430450188105 0.456268804382017 no 1513 0.456430541505202 498 5872756 YGL099W LSG1 SGTC_3221 9128209 49.47 µM 0.108806788381053 0.456529295492113 no 1514 0.456677869720103 502 16460723 SGTC_263 alizarin 107.927 µM 0.106930602489819 0.457313053150065 no 1515 0.457422017547553 506 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2769 toremifene 3.73 µM 0.106572427445859 0.457462696117228 no 1516 0.457564096845083 495 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_245 methotrexate 289.6 µM 0.105414920938309 0.457946335173516 no 1517 0.458023288416603 511 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2346 9031566 143.75 µM 0.104307454602583 0.458409124330523 no 1518 0.458462681134387 501 4771086 SGTC_1608 st001473 40.5 µM 0.104112570251855 0.458490568652644 no 1519 0.458540007726738 511 7292267 SGTC_2361 9034121 116 µM 0.103330105552928 0.458817586800302 no 1520 0.458850491360846 497 6496917 SGTC_2456 5770359 74.46 µM 0.102417346076059 0.459199094694928 no 1521 0.459212707945826 512 3118787 SGTC_878 0828-0289 13.7 µM 0.101468063359628 0.459595908139681 no 1522 0.459589454215523 486 745350 YLR208W SEC13 SGTC_2569 tetrandrine 100 µM 0.101388245640104 0.459629274902199 no 1523 0.459621133505688 462 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2393 9031399 185.94 µM 0.100671085827048 0.459929086988739 no 1524 0.459905782452645 500 1526623 YDL150W RPC53 SGTC_2974 9094440 9.66 µM 0.100458886462093 0.46001780232334 no 1525 0.459990010758619 467 25236134 SGTC_653 0203-0016 55.2 µM 0.0995006492054691 0.460418442474494 no 1526 0.460370386233819 502 295302 SGTC_947 3447-0010 211 µM 0.0990144207176957 0.460621750585614 no 1527 0.460563410146434 485 748350 SGTC_1147 3809-1045 12.3 µM 0.0983610355387351 0.460894968604697 no 1528 0.460822806867487 483 325925 SGTC_748 act1.228 77.9 µM 0.0981472862737327 0.46098435351143 no 1529 0.460907669867706 489 4421505 YNR035C ARC35 SGTC_649 1123-0311 367 µM 0.0967668169857549 0.461561680522928 no 1530 0.46145578821935 504 693629 YIL048W NEO1 SGTC_849 0386-0493 241 µM 0.0959833505991759 0.461889370652612 no 1531 0.461766897900441 493 726119 SGTC_2246 7293507 91.5585 µM 0.0956638287470585 0.462023020274213 no 1532 0.461893784789037 517 887656 SGTC_2320 7373003 200 µM 0.0949790561857053 0.462309461410559 no 1533 0.462165731223463 493 5415828 SGTC_2176 5809774 33.9695 µM 0.0940447192441916 0.462700327112953 no 1534 0.462536816653798 517 2870539 SGTC_549 1661-1316 519 µM 0.0930210286976351 0.463128613877727 no 1535 0.462943427584314 504 2857282 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.0922294878836727 0.46345980427319 no 1536 0.463257854971145 517 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_398 bronopol 33.3 µM 0.0917494362327761 0.463660676130505 no 1537 0.463448559284494 512 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_349 k015-0014 24 µM 0.0908003396124962 0.464057841447403 no 1538 0.463825620097878 493 2196908 SGTC_2511 berberine 10.47 µM 0.0907437356391012 0.464081529460279 no 1539 0.46384810897573 498 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2058 5236698 133 µM 0.0898066649061155 0.464473699584469 no 1540 0.464220425882966 471 766665 SGTC_1075 aripiprazole 15.2 µM 0.0892408005775045 0.464710534181595 no 1541 0.464445270270409 491 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2408 sulbentine 18.36 µM 0.0869890999955677 0.465653074995212 no 1542 0.46534008810327 459 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2945 9067681 61.76 µM 0.0853600939177584 0.466335082153894 no 1543 0.46598755888387 513 16456930 SGTC_673 1082-0474 110 µM 0.0851499066041382 0.46642308738265 no 1544 0.466071107305221 517 3098046 SGTC_976 1348-1067 47.6 µM 0.084320620363409 0.466770324720485 no 1545 0.46640075905245 496 5310671 YGL099W LSG1 SGTC_994 3910-0338 138 µM 0.0828118713426725 0.467402130253097 no 1546 0.46700056479312 514 3479481 SGTC_2275 7947463 200 µM 0.0823174698642217 0.467609184348229 no 1547 0.467197131311666 517 1225414 SGTC_2195 6536160 144.242 µM 0.0815921870834072 0.467912946794752 no 1548 0.467485507192043 494 3834386 SGTC_2083 5306046 65.942 µM 0.0815550858148614 0.467928486026934 no 1549 0.467500259292836 504 539837 SGTC_2325 6158266 200 µM 0.0813820946996999 0.468000941043463 no 1550 0.467569044116594 506 3623240 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.0812648491376317 0.468050048382969 no 1551 0.467615663913122 513 4213774 SGTC_1367 1812-0510 76.9 µM 0.0805859867667091 0.468334393838446 no 1552 0.467885605448339 505 1142582 YDR527W RBA50 SGTC_1815 st051655 58.2 µM 0.080377282587361 0.468421814052229 no 1553 0.467968597152899 510 5984156 SGTC_917 harmaline 728.087 nM 0.0796848906418553 0.468711848124712 no 1554 0.46824393837883 491 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3110 9122132 49.47 µM 0.0794265441679712 0.468820070399004 no 1555 0.468346678069475 495 918317 SGTC_1878 temozolomide 1 mM 0.0792846550340159 0.468879509252172 no 1556 0.468403105692933 517 5394 DNA alkylating agent. SGTC_1427 4048-4900 550 nM 0.0792158879167537 0.468908316771764 no 1557 0.468430453787221 514 24132586 SGTC_2959 9079155 11 µM 0.0790652592631392 0.468971417817175 no 1558 0.468490358034632 519 16189457 SGTC_753 1322-0200 289 µM 0.0787443413383818 0.469105858690677 no 1559 0.468617987834267 505 5403907 SGTC_1662 st014054 52 µM 0.0787134745261199 0.469118789787871 no 1560 0.468630263807007 505 2838777 SGTC_1224 0823-0416 294 µM 0.0784982555870209 0.469208952805651 no 1561 0.46871585889132 502 3598164 SGTC_351 caspofungin 25 nM 0.0773928318576239 0.469672079674289 no 1562 0.469155521514924 512 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_226 1,3-diallylurea 8.28947 mM 0.0772429898627433 0.469734860450854 no 1563 0.469215121409645 502 74537 YKL182W FAS1 SGTC_2857 9024691 58.44 µM 0.076892543657574 0.469881693284297 no 1564 0.469354514642982 511 16478292 SGTC_2651 TUB2.036 5 µM 0.0768033748495252 0.469919054619325 no 1565 0.469389982964799 492 15992207 YFL037W TUB2 SGTC_2010 4012422 159 µM 0.0760234256406637 0.470245861131038 no 1566 0.469700230580339 494 952393 SGTC_840 0245-0196 390 µM 0.0749155600614623 0.470710102279034 no 1567 0.470140948104445 520 3827528 SGTC_3282 9108498 15.4605 µM 0.0739238058829051 0.471125721772832 no 1568 0.470535506658053 507 16459645 SGTC_1489 4065-0444 182 µM 0.0738185732785099 0.471169823991877 no 1569 0.47057737400316 530 2877968 SGTC_143 4032-1194 15.74 µM 0.0729612612362474 0.471529130358217 no 1570 0.470918472184846 497 1806963 SGTC_1362 1611-0397 101 µM 0.0729195066357669 0.471546630641021 no 1571 0.470935085607352 508 27816 SGTC_2458 5808907 16.39 µM 0.0728325281077895 0.471583085455213 no 1572 0.470969692999075 514 2731747 SGTC_1604 st002052 72.4 µM 0.0727105093553186 0.471634226879999 no 1573 0.471018242715843 518 6254834 YHR062C RPP1 SGTC_1940 st075990 51.1 µM 0.0724328276128699 0.471750612699548 no 1574 0.471128730369889 509 1084979 SGTC_176 1486-1328 72.834 µM 0.072252866928743 0.471826041604041 no 1575 0.471200336674778 496 22310231 SGTC_2618 avocadyne 43.43 µM 0.0712447879019527 0.472248587483011 no 1576 0.471601468182391 506 3015189 SGTC_2866 9034245 58.44 µM 0.0706954481714294 0.472478861616618 no 1577 0.471820071803928 516 6462273 SGTC_1251 0490-5699 265 µM 0.0697819255903361 0.472861815510963 no 1578 0.47218361669658 508 3883818 SGTC_3130 9127414 49.47 µM 0.069622421397508 0.472928683163838 no 1579 0.472247095273552 521 1494646 SGTC_2037 5169046 200 µM 0.0688766646774322 0.473241330814057 no 1580 0.472543896643985 500 5718022 SGTC_1707 st032323 6.317 µM 0.0687033096660237 0.473314009747764 no 1581 0.472612891849389 520 3132057 YMR211W DML1 SGTC_2074 5212007 75.395 µM 0.0679502352894548 0.473629745788048 no 1582 0.472912624575905 529 758611 SGTC_2978 9011784 42.97 µM 0.0671464995284727 0.473966740530959 no 1583 0.47323253806373 492 2994934 SGTC_2482 5981709 142.65 µM 0.0667800092457397 0.474120410787733 no 1584 0.473378419094208 508 877755 SGTC_2975 9084847 53.72 µM 0.066770408562485 0.474124436429165 no 1585 0.473382240683079 511 27211724 SGTC_490 phenamil 164 µM 0.066475599156043 0.474248053598862 no 1586 0.47349959189135 524 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2103 5378138 10 µM 0.0662603424362329 0.474338314926335 no 1587 0.473585277978823 521 244142 SGTC_1574 spiramycin 23.7 µM 0.0660664233763743 0.474419630086168 no 1588 0.473662471345032 517 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2623 humulene 100 µM 0.0656374295455144 0.474599521816652 no 1589 0.473833244442434 508 6187145 An anti-inflammatory. SGTC_2670 beta-carotene 100 µM 0.0635370327316697 0.475480363833249 no 1590 0.474669435473771 514 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2448 5185112 27.17 µM 0.0634891007951415 0.475500466432699 no 1591 0.474688519020337 497 5718189 SGTC_1024 4507-0395 26 µM 0.0633208136347773 0.475571046369121 no 1592 0.474755521067891 490 4201836 SGTC_1048 3161-0300 24.5 µM 0.0624354961146745 0.4759423626944 no 1593 0.475108014138258 508 2165101 SGTC_2704 st078022 71.1 µM 0.0617399963973263 0.476234081067694 no 1594 0.475384944094197 513 54697681 SGTC_3043 9092303 49.47 µM 0.0613319036023196 0.476405256259576 no 1595 0.4755474416094 512 25236084 SGTC_716 1683-5115 658 µM 0.0600694264428266 0.476934831804862 no 1596 0.476050170070093 528 723597 SGTC_3167 9103034 49.47 µM 0.059666472704477 0.47710386878725 no 1597 0.476210637523026 508 5127859 SGTC_2695 st077686 51.995 µM 0.0596556781690549 0.477108397095108 no 1598 0.476214936262231 515 2876092 SGTC_1960 st011366 51.8 µM 0.0594209829938996 0.477206852456254 no 1599 0.476308400287264 527 3972846 SGTC_1673 st016611 27.3 µM 0.0581755515192553 0.477729337997725 no 1600 0.476804397396776 522 5226799 SGTC_2984 9022109 38.96 µM 0.0568318147768438 0.47829310764075 no 1601 0.477339585179329 516 6459207 SGTC_408 cantharidin 100 µM 0.0565548178029952 0.478409328166843 no 1602 0.477449913535884 512 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_622 1348-1566 26.3 µM 0.0563017497420427 0.478515510365876 no 1603 0.477550712477597 520 7340407 SGTC_47 0149-0135 24.25 µM 0.054310716076653 0.479350960094677 no 1604 0.478343805980582 526 5239155 SGTC_2357 9067248 200 µM 0.0536696812466615 0.479619961657958 no 1605 0.478599169417008 519 9150235 SGTC_1977 st070720 65.3 µM 0.053300681433979 0.479774811636946 no 1606 0.478746168634742 494 682188 SGTC_330 1488-0319 80.1 µM 0.0532711813679137 0.479787191408399 no 1607 0.478757920762082 532 6846614 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.0525334308101954 0.480096796458579 no 1608 0.479051829083554 529 364106 SGTC_2380 9035439 200 µM 0.0522526100245308 0.480214649122668 no 1609 0.479163706708738 499 6462575 SGTC_228 caffeine 993.056 µM 0.0518911437763353 0.480366348986135 no 1610 0.479307715506379 505 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2065 5221596 34.26 µM 0.0515835593388645 0.480495438014934 no 1611 0.479430259822528 520 788581 SGTC_2290 7904846 200 µM 0.0501518256271701 0.481096343995117 no 1612 0.480000700394323 505 2962154 SGTC_352 k048-0007 5.11 µM 0.0497580450522016 0.481261623311277 no 1613 0.480157600220269 529 6811911 SGTC_401 neomycin 50 µM 0.0482853076648657 0.481879795450712 no 1614 0.48074443184045 484 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2658 polymyxin b sulfate 77.05 µM 0.0482226034411214 0.48190611612685 no 1615 0.480769418099961 519 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_136 0097-0015 404.482 µM 0.047676873528196 0.482135194607985 no 1616 0.480986882694618 516 4861337 SGTC_1530 rhein 70.4 µM 0.0471337289090235 0.482363193729243 no 1617 0.481203322709463 529 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2228 7354201 200 µM 0.0467442535123168 0.482526689741529 no 1618 0.481358529835675 529 753451 SGTC_1061 3448-9325 110 µM 0.0465477529365847 0.482609178894536 no 1619 0.481436836984684 524 723482 SGTC_1857 st056007 79.3 µM 0.046139738910958 0.482780461842207 no 1620 0.481599436324808 525 619834 SGTC_1343 1487-0095 224 µM 0.0460841417443108 0.482803801596876 no 1621 0.481621592816928 532 4560101 YGL055W OLE1 SGTC_2729 fluphenazine 10.66 µM 0.0447153881197133 0.483378424333005 no 1622 0.482167084010427 531 3372 An atypical antipsychotic. SGTC_2416 tofa 880 nM 0.0446214265150878 0.483417872065135 no 1623 0.48220453188934 516 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2085 5307070 144.047 µM 0.0440083698657997 0.483675254506867 no 1624 0.482448866072394 517 2840351 SGTC_1270 0831-1170 17.3 µM 0.0438717418168026 0.483732616630754 no 1625 0.482503320184351 530 6764716 SGTC_3199 9111318 49.47 µM 0.0437782156131517 0.483771883005794 no 1626 0.482540595927673 522 8548020 SGTC_1897 st060201 15 µM 0.0428723279124203 0.484152222218304 no 1627 0.482901653794286 507 611878 SGTC_2661 dactinomycin 12.96 µM 0.0421633417392235 0.484449901909588 no 1628 0.483184242806164 529 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2121 5257820 149.641 µM 0.0416161326543479 0.484679662721925 no 1629 0.483402356192406 529 791256 SGTC_2979 9012552 45.46 µM 0.0414555550195318 0.484747086635296 no 1630 0.483466362163938 530 17100905 SGTC_626 0214-0009 33 µM 0.0412599470764196 0.484829219789177 no 1631 0.483544331732129 520 3437874 SGTC_2270 7924575 90.91 µM 0.0412133466398244 0.484848786783054 no 1632 0.48356290681675 510 1262135 SGTC_1702 st027038 51 µM 0.0411199903153306 0.484887986152752 no 1633 0.483600119056666 522 5521182 SGTC_2700 st077718 96.8 µM 0.0407579358829942 0.485040010498909 no 1634 0.483744436887809 522 904970 SGTC_2528 xanthyletin 44.79 µM 0.0405457328898601 0.485129114193965 no 1635 0.483829023711862 531 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0384447774039978 0.486011341375654 no 1636 0.484666530073015 534 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2834 9001755 58.44 µM 0.0381531393266085 0.486133810707748 no 1637 0.484782791534224 526 2989575 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.0353790769993125 0.487298803134329 no 1638 0.485888734200842 530 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1201 1889-3372 45.9 µM 0.0344121815229036 0.487704885568255 no 1639 0.48627423488759 512 5392199 SGTC_3125 9127534 49.47 µM 0.0336333210742545 0.488032005238142 no 1640 0.486584775458474 535 1639235 SGTC_2801 7907800 81.82 µM 0.0326926787426233 0.48842708365567 no 1641 0.486959831144535 538 6620925 SGTC_2856 9022925 19.48 µM 0.0326422812041371 0.488448251408631 no 1642 0.486979926128278 530 4944862 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.0319898495004186 0.488722285825769 no 1643 0.487240072840625 538 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3174 9107204 49.47 µM 0.0311443317154204 0.489077428176291 no 1644 0.48757721760279 514 3938802 SGTC_966 1300-0360 30.2 µM 0.0309802606027784 0.489146343883754 no 1645 0.487642640936544 533 70588 SGTC_1516 st013856 110 µM 0.0309523886653464 0.489158051121841 no 1646 0.487653754900881 532 5281404 A mutagen and neurotoxin. SGTC_810 3825-7150 143 µM 0.030941722324461 0.4891625313795 no 1647 0.487658008118053 524 22330411 YGL099W LSG1 SGTC_1866 st057638 64 µM 0.0300292116546571 0.489545824613236 no 1648 0.488021878069884 532 688802 SGTC_2129 girgensonine 121.053 µM 0.0296929963006688 0.489687051793052 no 1649 0.488155948801486 541 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_616 4092-0450 108 µM 0.0287640282296224 0.490077271279019 no 1650 0.488526395157795 534 787165 SGTC_2093 5331342 194.4 µM 0.0279654253142919 0.490412737582418 no 1651 0.488844863478667 531 33839 SGTC_3325 9138760 55.175 µM 0.0266035353504644 0.490984837400402 no 1652 0.489387976728514 537 43844959 SGTC_1030 k029-0042 36.7 µM 0.0265121128415808 0.491023242649443 no 1653 0.489424436172657 514 6080581 SGTC_2531 methyl deoxycholate 70.07 µM 0.0244970917918101 0.491869743802046 no 1654 0.490228051717065 538 16667744 Haematoxylin. SGTC_2749 bexarotene 57.39 µM 0.0243210904831949 0.491943682942934 no 1655 0.490298245166513 536 82146 An retinoic acid receptor inhibitor. SGTC_988 1497-1057 103 µM 0.0240657808695973 0.492050940440703 no 1656 0.490400069161403 538 3533044 SGTC_2154 5570129 200 µM 0.0240051464515286 0.492076413502628 no 1657 0.490424251808206 537 673366 SGTC_509 pifithrin 175 µM 0.0216030162654145 0.493085594823262 no 1658 0.491382313731188 542 4817 A p53 inhibitor. SGTC_3072 9116419 49.47 µM 0.0214607061529816 0.493145383504296 no 1659 0.491439074092744 533 17170162 SGTC_262 fenpropimorph 62.5 µM 0.0204826559375041 0.493556295379021 no 1660 0.491829173865911 542 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1810 st050138 53 µM 0.0198933306009238 0.49380389415366 no 1661 0.492064232751582 544 3444541 SGTC_963 1269-2853 151 µM 0.0196142933450783 0.493921129528612 no 1662 0.49217553079329 539 3668223 SGTC_2786 7743617 45.45 µM 0.0187388130209757 0.494288959270932 no 1663 0.492524732685396 537 583674 SGTC_1726 st035556 14.5795 µM 0.0185345106329633 0.494374796855747 no 1664 0.492606223392704 508 5919439 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.0178658565936845 0.49465573344261 no 1665 0.492872933577875 536 88881 An O-methylated flavonoid and antioxidant. SGTC_2052 5265182 7.135 µM 0.0174224516699138 0.49484203254746 no 1666 0.493049799015178 540 1239884 SGTC_469 w7 172 µM 0.0171128153934862 0.494972128662526 no 1667 0.493173307602175 543 45115570 A P450 inhibitor. SGTC_2864 9034755 47.6 µM 0.0162130493039388 0.495350175441342 no 1668 0.493532212496637 536 4930451 SGTC_1640 st009078 66.4 µM 0.0161454453366183 0.495378580176684 no 1669 0.493559179047797 543 690618 SGTC_732 3970-1727 52.7 µM 0.0158344847173527 0.495509234851128 no 1670 0.493683218527705 542 1275699 SGTC_23 0213-0011 39.996 µM 0.0145848512407821 0.496034291437845 no 1671 0.494181692463764 539 627608 SGTC_348 k064-0012 10.7 µM 0.0138308640511776 0.49635109646336 no 1672 0.494482459467025 541 5066323 SGTC_3139 9095020 49.47 µM 0.0135120525355932 0.496485053143751 no 1673 0.494609634973868 543 25236292 SGTC_1983 st071813 46.9 µM 0.00916592389580112 0.498311221636216 no 1674 0.496343376620452 528 11838595 SGTC_951 1171-0579 82.7 µM 0.00784666581086282 0.49886555994845 no 1675 0.496869665370436 541 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1495 4469-0029 237 µM 0.00765041906244575 0.498948020972316 no 1676 0.496947954145384 542 793680 SGTC_1803 st050068 52.4 µM 0.00736370561500306 0.499068495325593 no 1677 0.497062333038524 540 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1526 st051518 75 µM 0.00598032307796189 0.499649780939492 no 1678 0.49761421049475 543 673993 SGTC_2767 sibutramine 71.45 µM 0.00431337548759955 0.499649780939492 no 1679 0.498279217482671 547 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2479 5617353 43.85 µM 0.0040550362977439 0.499541228908555 no 1680 0.498382279005719 545 2731746 SGTC_1745 st081495 74 µM 0.00156623521873563 0.498495457818501 no 1681 0.499375162805657 547 13842402 YBL026W LSM2 SGTC_3170 9103054 49.47 µM 0.000689892888171267 0.498127229004905 no 1682 0.499724772579793 546 16432970 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.000569087973802633 0.498076468308679 no 1683 0.499772966758237 546 442882 SGTC_1666 st014829 29 µM 0.000461170694744059 0.498031122860028 no 1684 0.499816019517906 545 3858230 SGTC_470 aa-861 153 µM 0.00027598740051453 0.497953311288046 no 1685 0.499889896958474 547 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_566 0958-0068 16.5 µM -0.000125264410243316 0.497784710853082 no 1686 0.499950026730655 548 6815365 SGTC_2969 9091408 28.7 µM -0.000160143909400503 0.497770054990491 no 1687 0.499936111823864 549 4286311 SGTC_1169 aniline yellow 25.8 µM -0.00209348235345733 0.496957699322556 no 1688 0.499164821985983 549 6051 A DNA damaging agent. SGTC_112 phenothiazine 287.218 µM -0.00245534287215555 0.496805653036675 no 1689 0.499020460899641 549 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_855 0428-0020 25 µM -0.00253742343146642 0.496771164551567 no 1690 0.498987715596175 551 6812414 SGTC_1210 3013-0140 750 nM -0.00257458291513604 0.496755550943914 no 1691 0.498972891155448 549 905973 SGTC_225 nsc-122657 1.016 µM -0.00449545499347178 0.495948449551353 no 1692 0.49820657897404 552 275685 SGTC_1611 st001856 99.4 µM -0.00492713529971598 0.495767070675533 no 1693 0.498034365360863 551 647478 SGTC_532 1548-0774 215 µM -0.00492733879978022 0.495766985171227 no 1694 0.498034284177069 559 5932993 SGTC_606 k015-0008 38.6 µM -0.005738460177284 0.495426179147393 no 1695 0.497710698175311 556 1970475 SGTC_2047 4141938 200 µM -0.00675714546155935 0.494998166483821 no 1696 0.497304309494339 549 3807862 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.00880032038375546 0.494139720242418 no 1697 0.496489225433596 554 165506 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.00931018815987894 0.493925501800705 no 1698 0.496285825961798 555 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_969 1313-0238 134 µM -0.00945492494115376 0.493864691669513 no 1699 0.496228086881778 552 5212874 SGTC_164 4100-3994 89.624 µM -0.0110111991519086 0.493210843406038 no 1700 0.495607255868043 555 4615967 SGTC_2591 skatole 100 µM -0.0124745896692527 0.492596035619569 no 1701 0.495023487820923 553 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3302 9125395 16.351 µM -0.0139092289725048 0.491993324017073 no 1702 0.494451199393638 561 17599668 SGTC_1363 1636-0063 10.4 µM -0.0142652905923612 0.491843740436239 no 1703 0.494309165453879 553 6072185 SGTC_1144 3486-0183 12.5 µM -0.0146020721795338 0.491702257565694 no 1704 0.494174823034715 563 6744069 SGTC_3097 9117246 49.47 µM -0.0163825755928617 0.490954280958534 no 1705 0.493464590273886 559 16423892 SGTC_632 0781-2353 4.65 µM -0.0173375854330831 0.490553101169681 no 1706 0.493083650632137 561 6811515 YHR007C ERG11 SGTC_2752 diclazuril 33.15 µM -0.0197351842972192 0.489545962721549 no 1707 0.492127311614806 564 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2733 amorolfine 100 µM -0.0197773343414221 0.489528257697397 no 1708 0.492110499461348 552 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_414 piperonyl butoxide 100 µM -0.0205089656072685 0.489220941071078 no 1709 0.491818680030606 565 5794 A potent inhibitor of cytochrome P450. SGTC_2858 9025781 8.96 µM -0.0211773525892769 0.48894019535535 no 1710 0.491552090123361 565 4894980 YPL153C RAD53 SGTC_1654 st012436 41.8 µM -0.0226722462574333 0.48831230820487 no 1711 0.490955857210791 565 4323132 SGTC_1755 st041960 45.185 µM -0.0230025885971768 0.488173561246146 no 1712 0.490824104047315 558 2257073 SGTC_213 1246-0773 967 nM -0.0232814552763536 0.488056435673215 no 1713 0.490712882125372 572 6251622 SGTC_126 0417-1624 672.48 µM -0.023307264842938 0.488045595562084 no 1714 0.490702588391232 556 41912 YDL195W SEC31 SGTC_2787 5284540 71.43 µM -0.0247395212158564 0.487444056786629 no 1715 0.490131365673297 563 736958 SGTC_508 roscovitine 141 µM -0.0253596129569022 0.487183630889449 no 1716 0.489884062465209 558 160355 A CDKinase inhibitor. SGTC_1670 st016595 4.04 µM -0.0254250235102322 0.487156160106481 no 1717 0.489857975841195 554 597879 SGTC_1176 0848-0131 83.3 µM -0.0257007514405704 0.487040362000078 no 1718 0.489748012246586 559 6769040 SGTC_265 mycophenolic acid 32.932 µM -0.0277441993217976 0.486182205099669 no 1719 0.488933085648402 554 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_646 4092-0839 27.3 µM -0.0284794947086046 0.485873429303813 no 1720 0.488639861123662 556 877796 SGTC_927 2425-1185 123 µM -0.0289459487205549 0.485677553616896 no 1721 0.488453849589774 575 730375 SGTC_2855 9016525 58.44 µM -0.0290841279517244 0.485619529368737 no 1722 0.488398747251683 563 43811474 SGTC_2038 4100038 30.985 µM -0.0292641653251301 0.485543928498769 no 1723 0.488326953291005 568 3596803 SGTC_1728 st035614 33.7865 µM -0.0297708623677178 0.485331160267371 no 1724 0.488124898462231 584 15945546 SGTC_3311 9131146 2.8755 µM -0.0298377705495851 0.48530306502143 no 1725 0.48809821781239 571 4900406 YPR165W RHO1 SGTC_1812 st052057 4.327 µM -0.0298541510392808 0.485296186742417 no 1726 0.488091685852399 566 3645418 SGTC_1841 st054148 70 µM -0.0300700507321934 0.485205529402813 no 1727 0.488005592989377 576 675442 SGTC_3065 9113888 49.47 µM -0.0302187371356225 0.485143095697374 no 1728 0.487946302640813 573 16648368 SGTC_2354 9060492 162 µM -0.0304926739851703 0.485028070044584 no 1729 0.487837067989471 563 6471895 SGTC_2512 diallyl trisulfide 49.23 µM -0.0320199420803022 0.484386795672786 no 1730 0.487228073785154 558 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1931 st074438 57.1 µM -0.0324568314920953 0.484203360459004 no 1731 0.487053870677668 566 2787313 SGTC_2602 kawain 100 µM -0.0328350949044303 0.484044543035413 no 1732 0.486903045803152 559 5369129 SGTC_1157 4092-0394 27.6 µM -0.0330730769638954 0.483944625342566 no 1733 0.486808156235565 564 3659885 SGTC_2963 9082507 9 µM -0.0331939269165837 0.483893886405703 no 1734 0.486759970536971 561 16459611 SGTC_3228 9131799 49.47 µM -0.0349569217338896 0.483153721880493 no 1735 0.486057045668858 564 17015818 SGTC_2265 7929201 200 µM -0.0350405905961716 0.483118596300599 no 1736 0.486023687059105 564 1265108 SGTC_2407 paclitaxel 400 µM -0.0353129095053396 0.483004273202185 no 1737 0.485915114727509 605 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3096 9117468 49.47 µM -0.0358129600058256 0.4827943489998 no 1738 0.485715749553269 569 41316311 SGTC_1025 k007-0731 70 µM -0.0358184630078991 0.482792038832918 no 1739 0.4857135555807 560 6256118 SGTC_1055 3448-0672 86 µM -0.0359133279144434 0.482752214522064 no 1740 0.485675734292334 576 748378 SGTC_2745 rifampicin 24.3 µM -0.0362128008378996 0.482626496846895 no 1741 0.485556339546124 560 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1228 0124-0032 52.5 µM -0.036903479159652 0.482336559134663 no 1742 0.485280982835176 577 X1228 SGTC_1552 6-methylflavone 10.6 µM -0.0382044861399744 0.48179043893978 no 1743 0.484762322043236 558 689013 SGTC_2149 5554786 194.827 µM -0.0388006665666625 0.481540193243039 no 1744 0.484524656696409 573 745063 YPR165W RHO1 SGTC_2887 9044784 58.44 µM -0.0391035374097617 0.481413066513613 no 1745 0.484403920341407 570 6465546 SGTC_539 4859-0462 2.54 µM -0.0395828513392587 0.481211883592825 no 1746 0.484212849686299 572 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2159 5658611 73.75 µM -0.0400359363831624 0.481021714147234 no 1747 0.484032238079468 588 793844 SGTC_2893 9048488 25.97 µM -0.0413972673739101 0.480450360684053 no 1748 0.483489595625619 560 6467338 SGTC_3271 9137798 49.47 µM -0.0426399505365897 0.479928838994936 no 1749 0.48299427425645 569 6498326 SGTC_1678 st019265 80.2 µM -0.0426764803664922 0.479913508894205 no 1750 0.482979714216458 566 5367020 SGTC_987 1497-1013 404 µM -0.0440277074936271 0.479346474268027 no 1751 0.482441158945287 567 1676435 SGTC_691 1548-0686 185 µM -0.0446050214493678 0.479104220492109 no 1752 0.482211070053845 563 46495133 SGTC_1269 0831-0796 3.05 µM -0.0453485567593296 0.478792227924293 no 1753 0.481914742262635 563 927758 SGTC_1527 coumarin 137 µM -0.0461182542706444 0.478469271206409 no 1754 0.48160799834187 575 323 A hepatotoxic, DNA x-linker. SGTC_981 1488-1094 54.9 µM -0.0463443794008999 0.478374394234358 no 1755 0.481517883820861 563 3449522 SGTC_739 1486-1183 203 µM -0.0463644429262599 0.478365976093633 no 1756 0.48150988822711 572 4346692 SGTC_430 0958-0115 16.4 µM -0.0469796666859505 0.478107848684634 no 1757 0.481264716633067 584 6833180 SGTC_2382 9035899 200 µM -0.0470216249009968 0.478090244747654 no 1758 0.481247996205499 570 6462679 SGTC_2541 muurolladie-3-one 83.07 µM -0.0471085375857519 0.478053779904804 no 1759 0.481213361442219 581 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1638 st008370 60.6 µM -0.0480896913111658 0.477642142609223 no 1760 0.480822380921746 569 24207134 SGTC_2161 5662504 8.5105 µM -0.048693019058567 0.477389031803572 no 1761 0.480581969631222 564 2859334 SGTC_1655 st012546 55.1 µM -0.048700537423639 0.477385877722126 no 1762 0.480578973791753 570 720985 YLR208W SEC13 SGTC_479 n-linoleoylglycine 10 µM -0.0513540471138671 0.476272775400034 no 1763 0.479521700757261 569 6433346 An anti-infammatory. SGTC_175 3793-3120 23.7 µM -0.0522284161469896 0.47590603254204 no 1764 0.479173345507954 576 5322297 SGTC_1328 1441-0025 69.2 µM -0.0530317605978478 0.475569098015795 no 1765 0.478853301006284 579 4562601 SGTC_2889 9059656 51.95 µM -0.0534057698848445 0.475412238942752 no 1766 0.478704304036139 575 3949838 SGTC_848 0368-0089 85.6 µM -0.0549099337209721 0.474781433054215 no 1767 0.478105108927799 573 762535 SGTC_106 0092-0003 11.579 µM -0.0552121621053034 0.474654694168175 no 1768 0.47798471987868 575 1072148 SGTC_3294 9122953 26.2835 µM -0.0555914540180533 0.474495642471885 no 1769 0.477833636341892 566 16459826 SGTC_3092 9117248 49.47 µM -0.0558246391098147 0.474397861004739 no 1770 0.477740753187878 565 17141857 SGTC_742 0kpi-0133 140 µM -0.056647445314364 0.474052846172485 no 1771 0.477413019650892 579 2728852 SGTC_1124 fisetin 1.16336 µM -0.057009733170695 0.473900939662026 no 1772 0.477268720901917 607 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_867 0518-0118 155 µM -0.0571405042926899 0.473846108545845 no 1773 0.477216635677073 576 6848158 SGTC_2111 5486399 200 µM -0.0582391841754252 0.473385461949856 no 1774 0.476779054608126 578 689674 SGTC_445 e6 berbamine 66 µM -0.0589405315903296 0.473091424622732 no 1775 0.476499737304685 576 6610268 A calcium/calmodulin antagonist. SGTC_2160 5660466 132.927 µM -0.0614628917706662 0.472034056708379 no 1776 0.475495283292607 590 2859134 SGTC_2576 guaiol 23.12 µM -0.06165641788145 0.471952939028057 no 1777 0.475418223695375 579 227829 SGTC_1529 apigenin 74 µM -0.0649192635694283 0.470585474668862 no 1778 0.474119141418087 579 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1395 3486-0190 4.35 µM -0.0666699321817828 0.469851908298959 no 1779 0.47342223583952 590 6748079 SGTC_3248 9135562 49.47 µM -0.0671650792628197 0.469644449880176 no 1780 0.473225142517544 578 17650701 SGTC_288 1315-0019 35.1 µM -0.0696524890509498 0.468602392226635 no 1781 0.472235129064843 581 6811474 SGTC_2908 7930301 100 µM -0.0702967089957091 0.468332542110496 no 1782 0.471978750935032 587 2223178 SGTC_212 3807-4682 38.772 µM -0.0714295136100057 0.467858069565815 no 1783 0.47152796056517 578 3125501 YBL034C STU1 SGTC_353 1988-1175 58.3 µM -0.0721523643993084 0.467555329035697 no 1784 0.47124032700791 592 2788357 SGTC_2171 5739187 198.077 µM -0.0726072776940481 0.467364814274496 no 1785 0.471059317623272 575 2262761 SGTC_2939 9044578 71.43 µM -0.073102426276983 0.46715745773156 no 1786 0.470862305468343 588 2653634 SGTC_301 4119-0100 24.5 µM -0.0736393357252705 0.466932622797117 no 1787 0.470648685354863 598 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_249 wiskostatin 11.211 µM -0.0739882882908064 0.466786501896123 no 1788 0.47050985215384 592 2775510 A n-wasp and actin depolymerizer. SGTC_1308 1187-1617 41.4 µM -0.0744987008064186 0.466572779090212 no 1789 0.47030678745116 581 2882570 SGTC_2868 9035608 32.47 µM -0.0753065048047322 0.466234550568395 no 1790 0.469985423047693 574 6462614 SGTC_3220 9131269 49.47 µM -0.0763808132418701 0.465784774132805 no 1791 0.469558066911621 572 17722206 SGTC_2299 7976368 114.88 µM -0.0768409934819235 0.465592125639463 no 1792 0.469375019521503 585 2979718 SGTC_869 0564-0080 44.1 µM -0.077722138611523 0.465223268190418 no 1793 0.469024541653789 582 6843321 SGTC_1049 3226-0134 66 µM -0.0784545368850613 0.464916700604797 no 1794 0.468733246506253 578 5702385 SGTC_1190 1486-1332 13 µM -0.0786807369575085 0.464822021881105 no 1795 0.468643283826776 582 4150046 SGTC_2843 9000894 45.46 µM -0.078929132293509 0.46471805536108 no 1796 0.468544495650023 577 2242070 SGTC_783 0848-0141 92.7 µM -0.0789465297461298 0.464710773701787 no 1797 0.468537576660955 583 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1174 0739-0097 51.1 µM -0.0791537787048231 0.464624031089891 no 1798 0.468455154217556 597 728447 SGTC_2204 7233102 200 µM -0.0794369353311089 0.464505520569523 no 1799 0.468342545652281 597 2172480 SGTC_1908 st060353 56.5 µM -0.0794662503745372 0.464493251422881 no 1800 0.468330887496515 609 4227716 SGTC_452 diindolylmethane 8 µM -0.0795164380884267 0.464472246571736 no 1801 0.468310928653914 592 3071 Inhibits expression of several cancer promoting factors. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.0796347708489653 0.464422721655132 no 1802 0.468263869943115 583 1241132 A phosphatase inhibitor. SGTC_220 paclitaxel 373.376 µM -0.0796518781433933 0.464415561913977 no 1803 0.468257066730905 609 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1910 st062352 60.4 µM -0.079964439999395 0.464284750624548 no 1804 0.468132769069972 582 2245730 SGTC_1688 st021091 57.6 µM -0.0800621373581616 0.464243863773149 no 1805 0.468093918026798 593 3656366 SGTC_669 0108-0021 26.2 µM -0.0811243552852831 0.463799344522947 no 1806 0.467671528401991 638 17201 SGTC_1168 k815-0004 80.5 µM -0.0816954538207385 0.463560368619105 no 1807 0.467444446801082 583 642433 SGTC_795 0685-0265 78 µM -0.0829497936395535 0.463035537005217 no 1808 0.466945730416366 575 302754 SGTC_1238 0333-0287 48.8 µM -0.0830708822502694 0.462984875392559 no 1809 0.466897589199695 584 7226 SGTC_1260 0700-1617 7.75 µM -0.0831275174023785 0.462961180321851 no 1810 0.466875072920158 578 2853078 SGTC_2813 7971799 71.43 µM -0.0839764828437908 0.462606005121112 no 1811 0.466537564840739 605 2234054 SGTC_1115 galangin 695.678 nM -0.0840971101074302 0.462555541624572 no 1812 0.466489611153305 597 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_307 1501-1223 22.3 µM -0.0848356056493249 0.462246610810991 no 1813 0.466196043174529 601 2830329 SGTC_2318 6029776 164 µM -0.0849658956235314 0.462192109674508 no 1814 0.466144251990898 594 818325 SGTC_3215 9129942 49.47 µM -0.0853714641872813 0.462022462277259 no 1815 0.465983039300473 580 17682944 SGTC_2208 7283366 200 µM -0.0856035467956452 0.461925386334342 no 1816 0.465890789438509 585 898663 SGTC_701 4424-0219 185 µM -0.0859000833302044 0.461801353785167 no 1817 0.465772922634593 605 2911779 SGTC_1451 4152-0210 104 µM -0.0868851086731698 0.461389373259918 no 1818 0.465381418155551 618 659563 SGTC_2411 st077133 39.94 µM -0.0871397279874885 0.461282887087616 no 1819 0.465280223552255 578 1403142 YNL221C POP1 SGTC_2955 9076254 12.21 µM -0.0879802232044171 0.460931397292142 no 1820 0.464946197388331 579 16459619 SGTC_1202 1988-0068 29.6 µM -0.0884058724219932 0.460753405100113 no 1821 0.464777047027808 586 2850480 SGTC_1286 0929-0070 131 µM -0.088663038504188 0.460645870698755 no 1822 0.46467485390341 593 1420408 SGTC_2331 7980721 200 µM -0.0888259541040822 0.460577748773256 no 1823 0.464610115411897 596 2981221 SGTC_1361 1608-0041 5.61 µM -0.0901124294457294 0.460039859642961 no 1824 0.464098936068193 581 X1361 SGTC_1758 st042942 75.2445 µM -0.0904218922396385 0.45991048080508 no 1825 0.463975980229728 590 669317 SGTC_1478 0453-0656 35.7 µM -0.0913204962198911 0.459534820529866 no 1826 0.463618966202674 591 5258496 SGTC_1142 3253-1408 9.78 µM -0.0918274030614157 0.459322924671053 no 1827 0.46341758577298 582 256655 SGTC_312 4092-0653 6.84 µM -0.0920647991521125 0.459223692953602 no 1828 0.463323277922465 596 1148278 SGTC_473 2-arachidonoylglycerol 10 µM -0.0929134838350765 0.458868963032593 no 1829 0.462986146768495 576 5282280 An endocannabinoid. SGTC_402 epigallocatechin gallate 10 µM -0.0936509325001406 0.45856075369095 no 1830 0.462693224541106 608 65064 An antioxidant. SGTC_453 enantio-paf c16 10 µM -0.0944875336092716 0.458211134740192 no 1831 0.4623609424393 612 13871343 A lipid and platelet activating factor SGTC_1227 3909-8010 46.6 µM -0.0949107650240977 0.458034276935821 no 1832 0.462192852934471 584 15982272 SGTC_306 1672-3436 11.6 µM -0.0951064528213487 0.457952506714977 no 1833 0.462115136350896 587 6797378 SGTC_2732 terfenadine 20 µM -0.0957242073826563 0.457694383114576 no 1834 0.461869807235553 587 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_3297 9117502 71.43 µM -0.0959114457371645 0.457616150645694 no 1835 0.461795452053717 587 7453720 SGTC_2833 9001315 45.46 µM -0.0961045660860637 0.457535462265386 no 1836 0.461718762441854 579 2989378 SGTC_1062 mesoridazine 14.2 µM -0.0977796437653122 0.456835665190263 no 1837 0.461053635918006 579 4078 A neuroleptic. SGTC_2260 7964312 200 µM -0.0983501105126171 0.456597371783112 no 1838 0.460827144291772 616 231951 SGTC_1511 0906-3109 28.5 µM -0.0983623841474514 0.456592245053798 no 1839 0.46082227144683 596 2882180 SGTC_945 3381-0768 11.3 µM -0.0992145634291329 0.456236305257265 no 1840 0.460483955983132 596 1126236 YIL048W NEO1 SGTC_2847 9005661 71.43 µM -0.0994719711297309 0.456128797631932 no 1841 0.460381770652329 592 2991449 SGTC_2306 7482397 179.52 µM -0.100076472289057 0.455876337313248 no 1842 0.460141806969117 608 891448 SGTC_1403 3909-7815 62.9 µM -0.101025643412958 0.455479967036175 no 1843 0.459765051906656 596 6615483 SGTC_2999 9069765 71.4286 µM -0.101115158211143 0.455442588274875 no 1844 0.45972952260311 593 2097066 SGTC_824 1304-0008 100 µM -0.103069940462481 0.454626427309155 no 1845 0.458953730985006 597 768245 SGTC_2347 9049783 174.81 µM -0.103627420015626 0.454393703313377 no 1846 0.458732513390906 615 6467988 YPL169C MEX67 SGTC_2099 5377090 177.372 µM -0.103982814561271 0.454245349376939 no 1847 0.458591493312692 614 2243829 SGTC_3024 9090631 49.47 µM -0.104423500077244 0.454061400915626 no 1848 0.458416637131349 583 25236383 SGTC_2076 5212012 200 µM -0.104562436136708 0.454003409050775 no 1849 0.458361511438673 594 604802 SGTC_1717 st033143 58.0435 µM -0.104568444196742 0.454000901310633 no 1850 0.45835912763735 605 674616 SGTC_2303 7774051 200 µM -0.105171670225246 0.453749126539564 no 1851 0.458119794956574 605 2953184 SGTC_1961 st076550 68.7 µM -0.105216721594567 0.453730323721938 no 1852 0.458101921228372 594 1579337 SGTC_316 k060-0003 58.6 µM -0.105656985333953 0.453546578972474 no 1853 0.457927254989087 614 6152314 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.106053917383087 0.453380927293366 no 1854 0.457769786734909 608 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2395 5646831 180.19 µM -0.107249011052553 0.452882227861427 no 1855 0.457295717210771 610 6808628 SGTC_259 usnic acid 108.925 µM -0.107824744400105 0.452642007146985 no 1856 0.457067357062967 646 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2070 5230947 200 µM -0.107839690313791 0.452635771299421 no 1857 0.457061429071173 632 2835538 SGTC_283 0987-0079 11.7 µM -0.108795690483432 0.45223692598954 no 1858 0.456682271012827 590 411556 SGTC_182 3448-4371 550.524 µM -0.109778621328347 0.451826895398515 no 1859 0.456292473131251 585 3491403 SGTC_2820 7989630 71.43 µM -0.110562348027061 0.451499999813277 no 1860 0.455981703148056 574 2984098 SGTC_258 haloperidol 50.781 µM -0.111004511748217 0.451315586027586 no 1861 0.455806384494091 581 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1482 3346-2049 8.48 µM -0.113340627391671 0.450341434634357 no 1862 0.454880254370318 607 3826804 SGTC_1139 k015-0024 46.9 µM -0.113708379885742 0.450188110333201 no 1863 0.454734484711548 636 2766652 SGTC_2629 bisabolol 100 µM -0.114022852046068 0.450057005699682 no 1864 0.454609839134637 604 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3346 9158254 43.5805 µM -0.114963097175996 0.449665046514002 no 1865 0.454237186121271 589 17639500 SGTC_2423 st077119 87.2 µM -0.116439351972156 0.449049740651445 no 1866 0.453652174561746 590 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_563 tetrahydrosecaminediol 614 µM -0.118457439486062 0.448208796358942 no 1867 0.452852607983838 605 334274 A psychoactive constituent of the cannabis plant. SGTC_1084 voriconazole 435 nM -0.118602797135666 0.4481482342445 no 1868 0.452795024601447 608 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1889 st059080 5.18 µM -0.118986354237782 0.447988434018599 no 1869 0.452643083357646 624 176925 Isolated from Daphnopsis sellowiana. SGTC_792 4534-1957 155 µM -0.119042322650378 0.447965116774571 no 1870 0.452620912765533 590 1717904 SGTC_1849 st056239 19.2 µM -0.119228559354953 0.447887529185275 no 1871 0.452547140466552 604 5393181 SGTC_2256 7954252 200 µM -0.119314566257019 0.447851698746201 no 1872 0.452513071865724 623 2972920 SGTC_204 PMA1.184 62.41 µM -0.119797625992718 0.447650464178675 no 1873 0.452321731291836 602 2252213 YGL008C PMA1 SGTC_2029 5175081 200 µM -0.119808761644806 0.447645825411844 no 1874 0.452317320576319 603 1380876 SGTC_2791 5663188 71.43 µM -0.121021628521433 0.447140625735934 no 1875 0.451836952011568 611 54690634 SGTC_2686 alizarin 95.37 µM -0.12107735349239 0.447117416473522 no 1876 0.451814883244918 604 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1302 1159-0335 255 µM -0.12214042921129 0.446674683796435 no 1877 0.451393901838973 618 649284 SGTC_21 0849-0113 22.993 µM -0.122918388336899 0.446350733972349 no 1878 0.451085862130287 594 1560156 SGTC_1204 4049-0315 18.3 µM -0.123275482859947 0.446202048280005 no 1879 0.450944477287908 600 588402 SGTC_1046 2001-0062 216 µM -0.124147283628559 0.445839082928418 no 1880 0.450599330394681 602 739778 SGTC_2283 7944793 200 µM -0.126324198003526 0.444932945656515 no 1881 0.449737651227235 587 2970533 SGTC_2747 doxorubicin 7.63 µM -0.126673426430745 0.444787606512111 no 1882 0.449599439506955 588 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1760 st045453 10.4495 µM -0.127933160342176 0.444263402160341 no 1883 0.449100934250579 605 3323419 YIL048W NEO1 SGTC_235 0330-0087 5 mM -0.128819779184016 0.443894517995067 no 1884 0.448750127203298 605 46494818 YHR062C RPP1 SGTC_3022 9087993 49.47 µM -0.12911463113359 0.443771853468278 no 1885 0.448633472471963 582 17173644 SGTC_2735 sertaconazole 140 nM -0.130203645316405 0.443318847760971 no 1886 0.448202655294151 604 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1829 berberine 14.4 µM -0.130291303121933 0.443282387274397 no 1887 0.448167980260905 597 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_703 3875-0075 71.8 µM -0.130939432255792 0.443012818632503 no 1888 0.447911610387532 610 2850814 SGTC_760 0568-0725 82.9 µM -0.131431955087623 0.442807987099525 no 1889 0.447716805704265 605 3916171 SGTC_207 4185-0010 4.486 µM -0.13171139858302 0.44269177828606 no 1890 0.447606284652168 593 3761753 SGTC_449 xestospongin c 11.1929 µM -0.131952248288726 0.442591622964387 no 1891 0.447511030866214 628 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_280 3448-3607 3.04 µM -0.132885503074305 0.442203571529129 no 1892 0.447141966044406 597 626179 SGTC_256 clotrimazole 625 nM -0.133009846612695 0.442151873118486 no 1893 0.447092796612394 608 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3313 9133968 57.047 µM -0.133069875031982 0.442126915408016 no 1894 0.447069059736846 595 1494643 SGTC_585 0kpi-0023 191 µM -0.13308848914535 0.442119176359464 no 1895 0.447061699246831 613 64601 SGTC_1126 isoteolin 1.0172 µM -0.134603876639229 0.441489209578228 no 1896 0.446462538195325 596 133323 SGTC_680 0417-1641 114 µM -0.134616090082112 0.441484132886269 no 1897 0.446457709681307 603 2835990 SGTC_2567 aureobasidin a 60 nM -0.134821473047851 0.441398763964171 no 1898 0.44637651390321 609 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2073 5212005 126 µM -0.134855850697596 0.441384474910133 no 1899 0.446362923316887 605 691789 SGTC_1381 2324-0066 62.1 µM -0.135446639005085 0.441138925963515 no 1900 0.446129375630058 632 10885928 SGTC_3050 9093513 49.47 µM -0.135978183356256 0.440918019875552 no 1901 0.44591926395706 599 25236664 SGTC_911 3456-4043 236 µM -0.136424946949589 0.440732362289017 no 1902 0.445742676615644 602 914281 SGTC_1729 st035615 45.989 µM -0.136700674478946 0.440617787141648 no 1903 0.445633698190445 598 17385451 SGTC_1641 st009299 47.1 µM -0.137205842215374 0.440407883872341 no 1904 0.44543404658309 607 4046054 SGTC_2973 9094665 17.96 µM -0.137509036228989 0.440281911150838 no 1905 0.445314225358177 593 25237061 YIL048W NEO1 SGTC_3105 9121040 49.47 µM -0.13755146933563 0.440264281291462 no 1906 0.445297456339525 605 41448907 SGTC_2878 9043973 25.97 µM -0.137628795477373 0.440232154582169 no 1907 0.445266898293348 613 6465167 SGTC_773 4358-1457 44.6 µM -0.137829215499282 0.440148887863226 no 1908 0.445187697041915 650 1186886 SGTC_2109 5483026 200 µM -0.138559620135129 0.43984545559156 no 1909 0.44489907694705 604 759335 SGTC_1906 st060206 94.7 µM -0.138940743868182 0.439687139232706 no 1910 0.444748487124244 597 5133468 SGTC_2792 7535235 81.82 µM -0.139090460934379 0.439624950358962 no 1911 0.444689333013521 603 1281891 SGTC_1320 1313-0481 95.3 µM -0.139247980675357 0.43955952204983 no 1912 0.444627097349017 587 6813365 YLR208W SEC13 SGTC_2434 5670830 169.91 µM -0.140240261505532 0.439147400582151 no 1913 0.444235081065295 631 1549830 SGTC_2315 7733312 200 µM -0.140559656119387 0.439014761241006 no 1914 0.444108910742704 616 726316 SGTC_2191 5911152 200 µM -0.142499968472672 0.438209129055645 no 1915 0.443342552136019 614 2875902 SGTC_2703 st077852 53.4 µM -0.142998436243379 0.438002202712822 no 1916 0.443145708099176 629 6281836 SGTC_1398 3558-0053 112 µM -0.143970391649427 0.43759876870295 no 1917 0.442761925031673 628 4532369 SGTC_1466 k213-0079 57.5 µM -0.144708157356558 0.437292584170667 no 1918 0.442470649158551 621 3657981 SGTC_734 2023-0417 80 µM -0.145147690447147 0.437110188767881 no 1919 0.442297132707594 631 3935732 SGTC_2717 st081029 62.2815 µM -0.145298736390648 0.43704751150698 no 1920 0.442237506176528 637 5292846 SGTC_2119 5528445 120.635 µM -0.145584732885595 0.436928840177111 no 1921 0.442124610478102 620 791935 SGTC_2610 ononetin 44.17 µM -0.146001061953178 0.436756098821585 no 1922 0.441960275046992 634 259632 SGTC_2198 6589944 200 µM -0.148131817918585 0.435872204767985 no 1923 0.441119369686177 612 5290268 SGTC_95 0471-0001 561.058 µM -0.148972140935844 0.435523704304774 no 1924 0.440787807973242 607 4015405 SGTC_1965 Pectolinarigenin 58.4 µM -0.149392330829959 0.435349461061227 no 1925 0.440622031467908 610 5320438 An anti-inflammatory. SGTC_3320 9137005 35.139 µM -0.149927105891409 0.435127720097846 no 1926 0.440411063006123 598 4908713 SGTC_1218 1348-1416 30.7 µM -0.151131186985686 0.434628530564973 no 1927 0.439936115695232 612 6787668 SGTC_1043 0916-0009 19.3 µM -0.151356128867079 0.434535285389697 no 1928 0.439847397392999 599 3101130 SGTC_2080 5212524 12.4 µM -0.152025673934331 0.434257760392787 no 1929 0.439583343067226 614 260183 SGTC_989 1501-0895 10.3 µM -0.153485761130195 0.433652669916901 no 1930 0.439007609117281 613 2830112 SGTC_553 k007-0256 45.7 µM -0.155344992406054 0.432882391035317 no 1931 0.438274673648676 628 6287000 SGTC_110 0850-0284 111.64 µM -0.15606085547673 0.432585877030574 no 1932 0.437992526524367 600 3906265 SGTC_137 0438-0332 85.389 µM -0.156527911497053 0.432392440581341 no 1933 0.437808460099143 646 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_409 arachidonic acid 100 µM -0.157084498981724 0.432161944843709 no 1934 0.437589126967144 619 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.157892779145976 0.431827258481961 no 1935 0.437270644049154 615 688662 SGTC_3069 9117009 49.47 µM -0.159597111885113 0.431121702274429 no 1936 0.43659922710067 608 41904981 SGTC_2989 9073649 71.4286 µM -0.160230748416226 0.430859446624813 no 1937 0.436349654286436 630 21367202 SGTC_2452 5863136 48.41 µM -0.160354937009173 0.430808049811667 no 1938 0.436300742622736 609 2184096 SGTC_1123 mangostin 811.285 nM -0.160562887854717 0.43072198969485 no 1939 0.436218843386437 615 5281650 An antioxidant. SGTC_2200 6600604 21.907 µM -0.162713248132451 0.429832260249585 no 1940 0.43537210775306 648 2904777 SGTC_2742 clothiapine 36.27 µM -0.163913996525224 0.42933559532099 no 1941 0.434899424248618 619 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_93 0109-0045 59.227 µM -0.165056899935951 0.428862960655774 no 1942 0.434449598250259 611 88733 SGTC_2420 aureobasidin a 50 nM -0.166178889808296 0.428399073743839 no 1943 0.434008085971179 649 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_986 1493-0483 84 µM -0.168445566292012 0.427462218360369 no 1944 0.433116381737126 623 40079 SGTC_1004 4084-0029 199 µM -0.169727936360055 0.426932374074042 no 1945 0.432612051394066 632 716894 YLR208W SEC13 SGTC_391 gliotoxin 8.33 µM -0.17124227932682 0.426306853987991 no 1946 0.432016632175427 635 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1606 st000094 49.2 µM -0.171557534224851 0.426176656894201 no 1947 0.431892697575014 612 1242210 SGTC_1739 st037196 92.5 µM -0.171570601821824 0.426171260281998 no 1948 0.431887560519775 642 612214 SGTC_1304 1165-0502 251 µM -0.172528697211794 0.425775627004427 no 1949 0.431510951248704 614 767425 SGTC_858 0438-0351 2.77 µM -0.172530639264663 0.42577482513419 no 1950 0.431510187927364 634 2799119 SGTC_456 gingerol 170 µM -0.173406981258583 0.425413016425826 no 1951 0.43116576899266 666 442793 A herb. SGTC_924 2046-0044 21.3 µM -0.174361535404831 0.42501898832351 no 1952 0.430790670765325 615 3623589 SGTC_771 0250-0039 27.3 µM -0.174900055490344 0.424796726936944 no 1953 0.430579083335549 638 3005115 SGTC_1445 4239-0156 97.7 µM -0.175610367860218 0.424503598934201 no 1954 0.430300028283185 663 4008346 SGTC_326 k292-0812 17.5 µM -0.176753837945636 0.424031805433367 no 1955 0.429850875007874 653 3579357 SGTC_946 3434-1334 87.4 µM -0.178132974550019 0.423462921267163 no 1956 0.429309273101122 619 4047976 SGTC_2563 tomatine 8.54 µM -0.178351679793091 0.423372721512588 no 1957 0.429223397375309 649 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_944 3370-0224 231 µM -0.179170086419868 0.423035224910694 no 1958 0.428902075603659 631 4580514 SGTC_1454 4239-0054 42.6 µM -0.180072197176287 0.422663275629435 no 1959 0.428547944618582 648 1340767 SGTC_41 0478-0632 82.643 µM -0.181289152961079 0.422161621883768 no 1960 0.428070309822785 637 3750424 SGTC_2915 7971052 15.16 µM -0.18346589027956 0.421264642198591 no 1961 0.427216240053474 618 5741558 SGTC_2746 daunorubicin 9.88 µM -0.185460533206198 0.420443057627674 no 1962 0.426433916584991 619 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2826 7992541 19.48 µM -0.185541626077114 0.420409663139273 no 1963 0.426402117065044 650 2985066 SGTC_2828 7998861 71.43 µM -0.186200947038618 0.420138172440019 no 1964 0.426143590658705 615 2988188 SGTC_2943 9068529 45.32 µM -0.186936740230986 0.419835237391929 no 1965 0.425855116194735 618 3270634 SGTC_76 0433-0009 400.328 µM -0.187343463666081 0.419667804755204 no 1966 0.42569567356249 701 2841569 SGTC_1938 st074717 56.4 µM -0.187538473982701 0.419587531548037 no 1967 0.425619230447466 625 17250979 SGTC_81 0411-0046 9.971 µM -0.18814712446639 0.419337010817921 no 1968 0.425380660349765 637 12925265 SGTC_958 1222-0007 33 µM -0.18879911244615 0.419068688632907 no 1969 0.425125133748867 660 7312461 SGTC_2285 7945142 200 µM -0.190634613036983 0.418313500650972 no 1970 0.42440593509439 650 2970608 SGTC_2236 dapsone 200 µM -0.191210024241278 0.41807681856349 no 1971 0.424180525151973 626 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1094 duloxetine 25.4 µM -0.191397099749945 0.417999875766721 no 1972 0.42410724606477 626 60834 A selective serotonin reuptake inhibitor. SGTC_540 1187-0821 17.3 µM -0.191700444163954 0.417875119086055 no 1973 0.42398842902406 640 847520 SGTC_1289 0976-0073 69.1 µM -0.193105975309621 0.417297173303515 no 1974 0.423437986557245 663 3391136 SGTC_1686 st019653 115.5 µM -0.193667712050064 0.417066240497075 no 1975 0.423218037595965 663 97252 SGTC_2736 butenafine 14.65 µM -0.195022448829325 0.416509419225996 no 1976 0.422687686706191 632 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1958 st076513 41.9 µM -0.195145581798582 0.416458817639915 no 1977 0.422639489676138 661 732122 YGL099W LSG1 SGTC_1838 st055369 84.5 µM -0.195732303120298 0.416217723101602 no 1978 0.422409849594702 620 676036 SGTC_3189 9110682 49.47 µM -0.196273950397299 0.415995178293672 no 1979 0.422197874698962 654 17122418 SGTC_2342 7990637 118.86 µM -0.196465020187262 0.415916680509746 no 1980 0.422123104474896 677 2033102 YER133W GLC7 SGTC_2468 5987765 72.9 µM -0.196505145861816 0.415900195982726 no 1981 0.422107402685731 617 26772094 SGTC_2499 avocadenofuran 51.48 µM -0.196716023683048 0.415813565077252 no 1982 0.422024885009852 672 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_166 k072-0058 166.424 µM -0.200005537964585 0.414462728997917 no 1983 0.420738124981506 624 5846229 SGTC_1736 st036774 51 µM -0.200259933307131 0.414358303695019 no 1984 0.420638648183414 691 1272247 SGTC_42 0133-0086 60.653 µM -0.200672762645433 0.414188856604072 no 1985 0.420477229361637 658 162923 Model of phenazepam hydroxylation. SGTC_271 rotenone 740 µM -0.203928661525091 0.412853024905685 no 1986 0.41920462351614 653 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1237 0330-0133 46.1 µM -0.204420627675949 0.41265126813501 no 1987 0.419012405980376 667 X1237 YHR072W ERG7 SGTC_1471 k673-0312 37 µM -0.207190961230297 0.411515578468868 no 1988 0.417930363027044 636 24099884 SGTC_3120 9124077 49.47 µM -0.207247122975936 0.41149256276615 no 1989 0.417908433643683 646 18774327 YGL155W CDC43 SGTC_3017 9080681 49.47 µM -0.208194770522837 0.411104252338592 no 1990 0.417538445825122 644 16451914 SGTC_3131 9127911 49.47 µM -0.209308313508416 0.410648075492049 no 1991 0.417103781136014 678 45595681 SGTC_1464 k208-0027 110 µM -0.209897410885135 0.410406793199378 no 1992 0.41687387151754 622 X1464 SGTC_2921 7974240 10.71 µM -0.210350875745643 0.410221086315014 no 1993 0.416696915155106 663 2979074 YDR527W RBA50 SGTC_2203 7227154 166.4 µM -0.210461082146009 0.410175956668048 no 1994 0.416653911672515 635 896304 SGTC_709 3807-1509 243 µM -0.211834858233538 0.409613493814263 no 1995 0.416117936331439 659 1886677 YPL242C IQG1 SGTC_2880 9042983 58.44 µM -0.212408307742448 0.40937876228917 no 1996 0.415894252505559 672 6464714 SGTC_2612 dictamnine 15.46 µM -0.212488834303061 0.409345802749507 no 1997 0.415862843918009 654 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2608 thymoquinone 42.66 µM -0.212972317951324 0.409147926263212 no 1998 0.415674277215588 622 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_278 4092-0821 23.9 µM -0.213071219340764 0.409107451510017 no 1999 0.4156357064116 662 877900 SGTC_846 0335-0850 148 µM -0.213174703363628 0.40906510238122 no 2000 0.415595349284932 646 6819598 SGTC_1023 4482-3888 16 µM -0.213235723079573 0.409040131566763 no 2001 0.415571552981293 667 3303168 SGTC_1916 st067606 49.2 µM -0.213666594895573 0.408863818409856 no 2002 0.415403531573946 636 19590279 SGTC_1151 3909-8316 15.3 µM -0.21485876025549 0.408376079410716 no 2003 0.414938719247276 683 800431 SGTC_2780 5215298 71.43 µM -0.214962900172156 0.408333480389613 no 2004 0.41489812186935 682 2834131 SGTC_1300 1094-0077 113 µM -0.216092638015983 0.407871424462441 no 2005 0.414457769082195 630 5532636 SGTC_2656 pseudo-anisatin 100 µM -0.218641781808877 0.40682931168606 no 2006 0.413464551485015 631 6708809 A neurotoxin. SGTC_964 1287-0107 19.4 µM -0.219258067248852 0.406577467383292 no 2007 0.413224512307469 653 51516812 YPR165W RHO1 SGTC_2326 6164455 177.58 µM -0.219893456388687 0.406317856828376 no 2008 0.412977066320672 650 2888790 SGTC_1964 st076914 61 µM -0.220018234122332 0.406266879335547 no 2009 0.412928476930253 662 24208661 SGTC_2060 5238662 140 µM -0.222123269667053 0.405407114824023 no 2010 0.412108961862657 667 790130 SGTC_1377 2944-0135 198 µM -0.222565454031299 0.405226570291214 no 2011 0.411936862868235 653 1894137 SGTC_2082 5219693 150 µM -0.223472038575027 0.404856473572827 no 2012 0.411584071434373 663 2834649 SGTC_2179 6298986 200 µM -0.223516128230626 0.404838476936602 no 2013 0.411566916053943 652 738374 SGTC_311 1315-0136 58 µM -0.223561951721202 0.404819772792181 no 2014 0.411549086213736 648 6759207 SGTC_1090 efavirenz 20.7 µM -0.22385177071925 0.404701480068665 no 2015 0.41143632237974 645 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_962 1254-0300 21.5 µM -0.22446251626078 0.404452226271532 no 2016 0.41119871523686 644 7340576 SGTC_350 k064-0020 19.8 µM -0.22451672145687 0.404430106244817 no 2017 0.411177628580406 660 2790705 SGTC_2055 5235184 200 µM -0.225044807311464 0.404214621254448 no 2018 0.410972208483881 681 2836034 SGTC_1379 2144-0755 36.5 µM -0.225114696785416 0.404186105089094 no 2019 0.410945024008023 652 5392327 SGTC_2227 7312221 64.1025 µM -0.225804064639463 0.403904857875713 no 2020 0.410676907798021 630 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2862 9027634 71.43 µM -0.226201151349954 0.403742877600417 no 2021 0.410522487585007 630 5012562 SGTC_2673 kobusone 100 µM -0.227240897659686 0.403318820813017 no 2022 0.410118213837225 633 6710676 An epoxy ketone and protein crosslinker. SGTC_728 3030-5151 22.5 µM -0.22725333038071 0.403313750859203 no 2023 0.410113380328583 640 3125388 SGTC_3159 9100096 49.47 µM -0.227753904662886 0.403109634596738 no 2024 0.409918781818663 622 25236875 SGTC_851 0394-0702 453 µM -0.227757936740543 0.403107990566993 no 2025 0.409917214436402 638 762646 SGTC_2329 6138490 200 µM -0.227813907670846 0.403085169290023 no 2026 0.409895457106501 685 720019 SGTC_1773 st048542 73.5835 µM -0.227915375605297 0.40304379815842 no 2027 0.40985601463665 650 3237138 SGTC_1503 4585-0012 61.3 µM -0.228027506398138 0.402998080762915 no 2028 0.409812428376761 659 2922052 SGTC_1426 4048-4480 71.7 µM -0.228693928309712 0.402726397997057 no 2029 0.409553407125 664 14224343 SGTC_1370 2001-0092 44.6 µM -0.229042722463107 0.402584222467197 no 2030 0.409417855435941 642 790957 SGTC_998 3996-0085 177 µM -0.229489088492594 0.402402293468645 no 2031 0.40924440023806 624 715391 SGTC_887 0885-0007 9.62 µM -0.231021289235578 0.401777963103527 no 2032 0.408649131464893 649 5719458 SGTC_454 lyso-paf C-16 6.67 µM -0.2314136081912 0.401618143972357 no 2033 0.408496747125561 673 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1768 st044301 37.178 µM -0.232422206428603 0.401207346487234 no 2034 0.408105051438067 665 3931349 SGTC_2031 5180455 200 µM -0.232552325737912 0.401154357425268 no 2035 0.408054525436051 646 29949 SGTC_2823 7987624 58.44 µM -0.233197392111287 0.400891691059021 no 2036 0.407804065413695 694 2239440 SGTC_489 paxilline 115 µM -0.234134270223985 0.400510280870365 no 2037 0.407440370719611 689 105008 A toxic potassium channel blocker. SGTC_2105 5350118 200 µM -0.235012773556464 0.400152721654065 no 2038 0.407099409491994 650 2133313 SGTC_1430 4049-0248 69.1 µM -0.237117942249742 0.39929623902104 no 2039 0.406282646670897 662 22774488 SGTC_336 4111-0029 111 µM -0.238059801648145 0.398913202497075 no 2040 0.40591735607107 667 3131175 SGTC_928 2764-0428 58.7 µM -0.239218789707616 0.398441997427915 no 2041 0.405467966749412 667 662578 SGTC_802 4112-3352 742 µM -0.239724798171547 0.398236318004371 no 2042 0.405271804624942 637 704594 SGTC_634 1611-4317 11.2 µM -0.239751236408385 0.398225572317879 no 2043 0.405261556081056 659 2843522 SGTC_2002 4023503 131 µM -0.240234433027576 0.398029193120955 no 2044 0.405074260722721 689 4736863 YCR052W RSC6 SGTC_1692 fluoroquinolonic acid 71 µM -0.240615856000719 0.397874194677142 no 2045 0.404926429939783 691 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_83 0170-0301 39.027 µM -0.241597685216243 0.397475283993241 no 2046 0.404545957946395 638 3089716 SGTC_2483 5729050 27.16 µM -0.242674590220965 0.397037867931452 no 2047 0.404128746592872 688 2865180 SGTC_1323 1348-1351 11.2 µM -0.242814972705575 0.396980857060677 no 2048 0.404074368047916 641 6989654 SGTC_2463 5473429 200 µM -0.243466409503064 0.396716330243316 no 2049 0.403822051830112 663 5399405 SGTC_296 1222-0039 74.9 µM -0.243487571046386 0.396707738040707 no 2050 0.403813856155863 661 5984176 SGTC_1213 1315-0166 115 µM -0.244576508101114 0.396265665677766 no 2051 0.403392177762506 666 768401 SGTC_979 1426-2828 121 µM -0.245628635097133 0.395838663629744 no 2052 0.402984860297863 664 747872 SGTC_1948 st076329 66.6 µM -0.245838003363724 0.395753707146372 no 2053 0.402903818602849 677 24208413 SGTC_1547 harmine 94.2 µM -0.245950504085766 0.395708059170847 no 2054 0.402860273854193 622 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_177 1327-0068 8.361 µM -0.247389508622399 0.395124299129069 no 2055 0.402303396403363 634 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1321 1326-2144 215 µM -0.249057584343542 0.394447906467722 no 2056 0.401658119280905 687 3513030 SGTC_2881 9058953 51.95 µM -0.250918791215745 0.393693576090649 no 2057 0.400938447896857 634 17122249 SGTC_1085 doxorubicin 7.67 µM -0.25111716287565 0.393613201309834 no 2058 0.400861763458789 676 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1236 0330-0013 258 µM -0.251167090683699 0.393592972638942 no 2059 0.400842463491407 673 4617066 SGTC_655 k060-0012 42 µM -0.251518714197432 0.393450517554343 no 2060 0.400706547650869 672 5994525 SGTC_3201 9113999 49.47 µM -0.25190692135123 0.393293257712692 no 2061 0.400556504805623 686 16649224 SGTC_1943 st076331 65.2 µM -0.252326730360971 0.393123215785772 no 2062 0.400394264292665 659 24208415 SGTC_2413 inermin 26.06 µM -0.253095688671687 0.392811805256579 no 2063 0.400097135193486 696 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3257 9139206 32.98 µM -0.253413657857541 0.392683055044337 no 2064 0.399974287296982 674 4910041 SGTC_97 0535-0701 19.132 µM -0.253885568786874 0.392491993296611 no 2065 0.399791982015311 647 2832013 YGL099W LSG1 SGTC_3177 9107506 49.47 µM -0.25400151401844 0.392445054717687 no 2066 0.399747194217004 659 8897194 SGTC_52 0329-0193 875 nM -0.254517233084334 0.392236293039765 no 2067 0.399547996135682 672 3739292 SGTC_3217 9129673 49.47 µM -0.255218653545725 0.391952409723625 no 2068 0.399277112287948 678 17248312 SGTC_476 mead acid 10 µM -0.255312694486624 0.391914353249367 no 2069 0.399240797994843 660 5312531 An omega 9 fatty acid. SGTC_1276 0871-0068 94.2 µM -0.255453907169384 0.39185720926383 no 2070 0.399186269778807 651 3414906 SGTC_954 1189-0853 2.85 µM -0.256270426089449 0.39152683751622 no 2071 0.398871015735344 661 2828194 SGTC_25 0118-0223 35.662 µM -0.257165864632727 0.391164624033361 no 2072 0.398525367041596 658 5333628 SGTC_1613 st002381 52.1 µM -0.257387737008259 0.391074889105597 no 2073 0.398439734264459 642 551167 SGTC_200 k038-0079 37.545 µM -0.25814898289247 0.390767051959471 no 2074 0.398145964721359 663 3436683 SGTC_17 0960-0276 49.807 µM -0.258329375781245 0.390694113632456 no 2075 0.398076358432787 662 6821114 SGTC_188 3229-0966 278.469 µM -0.258440113617824 0.390649340864688 no 2076 0.398033630806215 662 5722370 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.261112541916616 0.389569283841335 no 2077 0.397002860025309 658 688788 SGTC_1680 diphenhydramine 100 µM -0.26213823561016 0.389154977493488 no 2078 0.396607434707015 664 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.262789329778894 0.388892047704763 no 2079 0.396356480089539 648 368090 SGTC_455 paf C-16 10 µM -0.265893039520758 0.387639385401202 no 2080 0.395160792929467 659 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1411 3909-8223 150 µM -0.266347227723669 0.387456172017175 no 2081 0.394985901889361 686 X1411 SGTC_1842 st055362 61.2 µM -0.266753230420396 0.387292417228047 no 2082 0.394829583208449 645 676032 SGTC_1863 st057641 20.1 µM -0.266973920092591 0.387203413937672 no 2083 0.394744620630723 660 3921635 SGTC_3239 9133757 49.47 µM -0.267928709409657 0.386818419477693 no 2084 0.394377097214444 682 17036923 SGTC_852 0418-0143 439 µM -0.268908279398312 0.386423548560429 no 2085 0.394000132768972 673 5369229 SGTC_881 0833-0569 170 µM -0.26954965916231 0.386165067955793 no 2086 0.3937533666333 649 5418700 SGTC_363 0455-0021 3.06 µM -0.269684902303668 0.386110570453747 no 2087 0.393701338274438 671 4597466 SGTC_2292 7671323 168.05 µM -0.271192126560906 0.385503372494296 no 2088 0.393121634127478 673 937504 SGTC_2931 9014674 55.67 µM -0.274171003369095 0.384304133289866 no 2089 0.391976605285627 671 2996810 SGTC_2396 5342950 42.78 µM -0.276892290064837 0.383209561770322 no 2090 0.390931406434106 653 1886677 SGTC_925 2064-1272 59.6 µM -0.27720269611309 0.383084767509056 no 2091 0.390812234761574 692 6815817 SGTC_1514 1189-1591 158 µM -0.277485256680433 0.382971178669411 no 2092 0.390703762493298 719 767698 YMR146C TIF34 SGTC_1477 0139-0234 16 µM -0.277616970876858 0.382918233237581 no 2093 0.390653201593195 650 620880 SGTC_2112 5488546 200 µM -0.277961918256039 0.382779584384558 no 2094 0.390520796004176 692 600757 SGTC_2266 7929956 200 µM -0.279328808973932 0.382230321388459 no 2095 0.389996249721129 666 2967153 SGTC_769 0302-0231 76 µM -0.279328906340416 0.382230282271733 no 2096 0.389996212363722 679 571869 YER009W NTF2 SGTC_2781 5567276 71.43 µM -0.279994588486528 0.38196287435263 no 2097 0.389740828336394 694 2853274 SGTC_1475 4092-1048 11.7 µM -0.282020170587814 0.381149534491339 no 2098 0.388964021955467 678 2881759 SGTC_1305 1181-0477 144 µM -0.282467731405733 0.380969894309519 no 2099 0.388792443081118 667 6252086 SGTC_1291 0993-0025 5.79 µM -0.283055236402157 0.380734122831873 no 2100 0.388567247522144 677 4353356 SGTC_3268 9137683 49.47 µM -0.283124778320109 0.380706217912293 no 2101 0.388540594002869 683 1953228 SGTC_2777 climbazole 1.536 µM -0.283345678717411 0.380617581853852 no 2102 0.388455932390802 663 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_317 4495-0002 170 µM -0.284103941648781 0.38031337732613 no 2103 0.388165363189769 687 15991618 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.284258924839265 0.38025120933213 no 2104 0.388105980748275 709 6708760 SGTC_1926 methyl fluorone black 53.6 µM -0.286212347548011 0.379467903787759 no 2105 0.387357743589546 651 72721 Reacts with homocysteine. SGTC_1697 st025554 27.742 µM -0.286274603596387 0.379442947766714 no 2106 0.38733390395539 654 1269519 SGTC_3023 9089636 49.47 µM -0.287155502181073 0.379089883770681 no 2107 0.386996628091808 657 17249241 SGTC_3113 9123498 49.47 µM -0.288633936694791 0.378497554259399 no 2108 0.386430761275033 680 8897275 SGTC_163 TUB2.036 7.546 µM -0.288854655845496 0.378409148367104 no 2109 0.386346302300103 653 15992207 YJR013W GPI14 SGTC_2904 7225135 42.03 µM -0.289239754172856 0.378254917992397 no 2110 0.386198955938718 688 4446116 SGTC_1892 st058411 7.36 µM -0.290576293811832 0.377719789711079 no 2111 0.385687696452894 673 3934738 SGTC_2518 prenyletin 46.28 µM -0.291947760607563 0.377170921048203 no 2112 0.385163282839904 652 3873459 A coumarin with calcium channel inhibitory activity. SGTC_598 3937-0236 20.2 µM -0.293088187680955 0.376714704610538 no 2113 0.38472737269534 675 1379313 SGTC_82 0054-0107 293.755 µM -0.295225602676978 0.375860117153722 no 2114 0.383910772526621 683 3104697 SGTC_1836 st055642 81 µM -0.29538660319339 0.375795770054031 no 2115 0.38384928304122 701 8571 SGTC_1850 st056238 17 µM -0.295870353909485 0.375602450121869 no 2116 0.383664546061194 674 5393177 SGTC_1118 chelidonine 707.474 nM -0.296408048091394 0.375387609561174 no 2117 0.383459239926322 675 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_3179 9107801 49.47 µM -0.296553320306172 0.375329571365075 no 2118 0.383403776689945 664 4818259 SGTC_2523 spermine 47.74 µM -0.297222243408175 0.375062364054998 no 2119 0.383148420503244 669 1103 A DNA binding polyamine. SGTC_554 4483-2211 187 µM -0.297462755679729 0.374966303925503 no 2120 0.383056619218093 666 747107 SGTC_2918 7977171 22.06 µM -0.298834761195963 0.374418476091796 no 2121 0.382533063277663 667 2236483 SGTC_2064 5220758 200 µM -0.299129379345798 0.374300871079623 no 2122 0.382420665244937 672 788518 SGTC_427 1354-0053 47.3 µM -0.300555083007203 0.373731927307013 no 2123 0.381876893552242 709 6813657 SGTC_1909 st060837 51.5 µM -0.300877004851468 0.373603498637956 no 2124 0.381754142886558 712 678937 SGTC_1997 st073024 93.8 µM -0.301108132623852 0.373511300340486 no 2125 0.381666019858313 693 686268 SGTC_399 oxolinic acid 75 µM -0.301609389120802 0.373311370907185 no 2126 0.381474924827864 671 4628 A DNA gyrase inhibitor. SGTC_1876 myriocin 605 nM -0.30265192804489 0.372895656713615 no 2127 0.381077568174556 707 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1107 amlodipine 47 µM -0.303054309659987 0.372735245901145 no 2128 0.38092423665305 701 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_385 1494-0393 12.4 µM -0.304520389876676 0.372150974856477 no 2129 0.38036573051562 696 3090647 SGTC_1645 Cervolide 78 µM -0.305524477838383 0.371750989390124 no 2130 0.37998336500172 676 23173 A fragrance. SGTC_2587 piperic acid 92.2 µM -0.306230322598086 0.371469894005304 no 2131 0.379714643298863 670 5370536 SGTC_2381 9035592 200 µM -0.308088327858121 0.370730290577228 no 2132 0.379007561285301 698 4749657 SGTC_2546 rhodinyl acetate 100 µM -0.308748291989909 0.370467697939309 no 2133 0.378756502777396 686 6708682 SGTC_2128 5255449 168.493 µM -0.308772941902146 0.370457891172317 no 2134 0.378747126636616 662 736008 SGTC_412 gemfibrozil 100 µM -0.308914202563988 0.370401693391267 no 2135 0.378693396387604 668 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1701 st028638 40.4 µM -0.30893571877754 0.370393133830809 no 2136 0.378685212634004 687 3490878 SGTC_115 0527-0192 112.043 µM -0.309613450667913 0.37012355201298 no 2137 0.378427463224246 697 4233931 SGTC_2016 5121758 140 µM -0.310970020196623 0.369584140296187 no 2138 0.377911706441184 710 2795203 SGTC_2937 9044753 11.33 µM -0.311414633731253 0.369407404727038 no 2139 0.377742715253361 645 6465530 YGL099W LSG1 SGTC_231 b-estradiol 524 µM -0.314627455673604 0.368131118036279 no 2140 0.376522265242189 666 450 A steroid. SGTC_1195 1502-0147 41.1 µM -0.314679454655628 0.36811047347143 no 2141 0.376502522573631 679 817940 SGTC_1185 1319-0113 81.3 µM -0.315297554384625 0.367865105548034 no 2142 0.376267870849077 715 4672763 SGTC_1093 fluphenazine 7.97 µM -0.31554986037661 0.367764962770261 no 2143 0.376172100032338 700 6602611 An atypical antipsychotic. SGTC_3066 9117245 49.47 µM -0.316804279880737 0.367267204656792 no 2144 0.375696058246385 699 17176980 SGTC_2836 9010338 19.48 µM -0.317317581625208 0.36706358894191 no 2145 0.375501318991738 663 2994051 SGTC_2650 prasterone 100 µM -0.317407953595765 0.367027744202154 no 2146 0.375467036455996 685 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_775 4577-0580 57.3 µM -0.31741014183006 0.367026876284928 no 2147 0.375466206363235 721 2006902 SGTC_205 1486-1330 71.903 µM -0.320700570139768 0.365722568064064 no 2148 0.37421865759191 685 4118834 SGTC_146 3448-8650 53.125 µM -0.321093431230098 0.365566943364188 no 2149 0.37406979404286 716 2891488 YIL048W NEO1 SGTC_3310 9130229 44.1445 µM -0.321485070392265 0.365411824731394 no 2150 0.373921412198463 710 7761258 SGTC_3345 9148410 3.559 µM -0.321744132933917 0.365309228529351 no 2151 0.373823270435487 692 4903596 SGTC_3342 9147791 14.508 µM -0.322251295420999 0.365108405537712 no 2152 0.373631163603707 696 1838168 SGTC_1257 0669-0121 16 µM -0.322784051365332 0.364897488047775 no 2153 0.373429396100536 670 4307855 SGTC_2239 6685329 187.64 µM -0.324163541529935 0.364351539506224 no 2154 0.372907111311877 682 805680 SGTC_1307 1187-1599 12.2 µM -0.324284867479665 0.364303536560458 no 2155 0.372861187602765 680 1538471 SGTC_2334 9017922 200 µM -0.324481809887576 0.364225620286871 no 2156 0.37278664576634 675 3163164 SGTC_3166 9102297 49.47 µM -0.325856921039671 0.363681741951835 no 2157 0.372266305121704 696 25237072 SGTC_2067 5224629 34.075 µM -0.326313971733208 0.363501031876749 no 2158 0.372093409181577 687 2835000 SGTC_1266 0828-0227 32.9 µM -0.326937909340654 0.36325438658538 no 2159 0.371857423867385 694 3913820 SGTC_329 k048-0121 21.3 µM -0.327300110336739 0.363111232931669 no 2160 0.371720454496019 685 6832902 SGTC_1920 st075728 45.7 µM -0.327958472632354 0.362851075646452 no 2161 0.371471530813048 706 3400306 SGTC_3273 9137859 49.47 µM -0.32825500605608 0.362733918686073 no 2162 0.371359430470369 686 2377234 SGTC_91 0417-1751 58.384 µM -0.330492069641903 0.361850495276896 no 2163 0.370514091916262 696 6795624 SGTC_1801 st050089 28.441 µM -0.330539187136112 0.361831896325303 no 2164 0.370496293926159 683 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_801 0866-0028 10.1 µM -0.331064007164332 0.361624753255891 no 2165 0.370298069072942 671 6849771 SGTC_128 0906-2981 13.371 µM -0.331403712238871 0.361490695472448 no 2166 0.370169780610528 720 6740226 SGTC_3040 9091894 49.47 µM -0.331982724162259 0.36126223924229 no 2167 0.369951152025932 678 25236966 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.332051730637067 0.361235015191954 no 2168 0.369925098735173 680 3256 An antibiotic and ribosome inhibitor. SGTC_517 1365-0151 113 µM -0.333080475135577 0.360829244037435 no 2169 0.369536768645153 708 768657 SGTC_68 0986-0284 82.829 µM -0.338180876933097 0.358819796338114 no 2170 0.36761344289314 648 423278 YIL048W NEO1 SGTC_2155 5570423 76 µM -0.338552151376454 0.358673673923145 no 2171 0.367473566791652 709 797402 SGTC_3052 9092717 49.47 µM -0.338675338282335 0.35862519584406 no 2172 0.367427160520968 713 25237534 SGTC_1211 1056-0033 32.3 µM -0.339049567212057 0.358477938485872 no 2173 0.367286195003656 708 6741922 SGTC_1063 disulfiram 1.84 µM -0.339439988579074 0.35832433190485 no 2174 0.367139149140021 689 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2474 5321570 43.32 µM -0.340008380208153 0.358100746055248 no 2175 0.366925108508674 708 2841384 SGTC_602 3130-1533 38.1 µM -0.34136304420109 0.357568063817537 no 2176 0.366415146235493 708 720941 SGTC_261 5-fluorouridine 15.376 µM -0.341588712859071 0.357479353098814 no 2177 0.366330216320621 682 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3037 9091026 49.47 µM -0.343233408163878 0.35683305352154 no 2178 0.365711436739184 709 25236398 YIL048W NEO1 SGTC_916 4466-0038 42 nM -0.343655003533871 0.356667449439439 no 2179 0.365552877144528 709 5722064 YGL116W CDC20 SGTC_1664 st014217 9.02 µM -0.343948331784101 0.35655224504849 no 2180 0.365442571625648 701 3982782 SGTC_1312 1218-2183 165 µM -0.34453440183141 0.356322105798578 no 2181 0.365222214459602 690 6744073 SGTC_3006 9075424 71.4286 µM -0.344985722533997 0.356144915864344 no 2182 0.365052552177031 698 7465181 SGTC_287 k060-0039 29.6 µM -0.345965069267774 0.355760528111871 no 2183 0.364684483126375 690 5861974 SGTC_1647 st011722 22.4 µM -0.346861156083364 0.355408947809882 no 2184 0.364347814980207 710 2854783 SGTC_75 0159-0059 199.013 µM -0.347283408232831 0.355243319498887 no 2185 0.364189207174877 727 5377270 SGTC_1290 0986-0249 10.2 µM -0.347432570693846 0.355184817090694 no 2186 0.364133183815589 711 53329 SGTC_2305 7443522 69.23 µM -0.348606196139844 0.354724633355709 no 2187 0.363692487690433 688 5415886 SGTC_3163 9099914 49.47 µM -0.348988526839558 0.354574765525544 no 2188 0.363548961489718 693 16268368 SGTC_2400 5203494 178.7 µM -0.349863190127602 0.354231995478314 no 2189 0.363220686637307 689 6777674 SGTC_1443 4112-3303 14 µM -0.352008062336726 0.353391946015302 no 2190 0.362416108050854 698 704433 SGTC_1695 st026914 34.495 µM -0.35540427788673 0.352063262931476 no 2191 0.361143372250457 704 3289191 SGTC_1950 st077106 7.18 µM -0.355792975007865 0.351911309810305 no 2192 0.360997805215601 672 13831864 SGTC_666 0272-0154 136 µM -0.356365538436042 0.351687521029035 no 2193 0.360783416936957 695 6870312 SGTC_2245 6637752 200 µM -0.356582356327474 0.351602790269374 no 2194 0.360702243958129 685 681890 SGTC_1508 1080-0625 72.9 µM -0.357187208736788 0.351366457592501 no 2195 0.360475830552615 682 767111 SGTC_588 3970-1144 52.9 µM -0.358765404755168 0.350750083194973 no 2196 0.359885297521613 691 1888707 SGTC_1676 st018489 23.4 µM -0.35916042930481 0.350595865242641 no 2197 0.359737538577902 711 3696235 SGTC_253 dyclonine 31.25 µM -0.360377629308961 0.350120824128096 no 2198 0.359282376779209 694 3180 An oral anasthetic. SGTC_1263 0774-1208 64.8 µM -0.361117999764647 0.349831991644014 no 2199 0.359005619013712 752 906585 SGTC_189 3970-0742 2.116 µM -0.361249295016198 0.349780779954077 no 2200 0.358956547275706 724 2891807 SGTC_973 1325-0077 65.9 µM -0.361685466687652 0.349610670894615 no 2201 0.358793544368884 719 2835149 SGTC_2816 7982706 58.44 µM -0.364004589642903 0.348706709506743 no 2202 0.35792729105883 712 2981853 SGTC_834 0312-0008 75.7 µM -0.364565095022093 0.348488361010833 no 2203 0.357718037111817 717 6385573 YIL048W NEO1 SGTC_1888 azatryptophan 97.5 µM -0.364720516906668 0.348427824295783 no 2204 0.357660020897228 702 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_3307 9126885 69.2785 µM -0.364916615470473 0.348351449551066 no 2205 0.35758682549692 706 24824909 SGTC_2666 tannic acid 100 µM -0.365180003292152 0.34824887725317 no 2206 0.357488522070496 712 16134267 A thiamine antagonist. SGTC_1429 4049-0205 9.46 µM -0.365917118590504 0.347961878158052 no 2207 0.357213461069535 697 22774478 SGTC_154 3389-1638 511.116 µM -0.366019321143826 0.347922092012707 no 2208 0.357175329148321 755 5238686 SGTC_3019 9081971 49.47 µM -0.36683467856923 0.34760474379928 no 2209 0.356871169219238 712 16451803 SGTC_3136 9095672 49.47 µM -0.366868225847355 0.347591689027076 no 2210 0.356858656731008 671 17217380 SGTC_2924 9010168 62.78 µM -0.366903984470177 0.347577773919048 no 2211 0.35684531962338 704 2993929 SGTC_909 3448-9333 149 µM -0.368223290363557 0.347064523021492 no 2212 0.356353372651857 690 3344074 SGTC_2883 9059145 45.46 µM -0.368291462609463 0.347038009515726 no 2213 0.356327958853995 704 16476510 SGTC_1457 k015-0032 57.3 µM -0.369412943545265 0.346601951441854 no 2214 0.355909975836942 719 4302660 SGTC_3238 9133470 49.47 µM -0.369752752682019 0.346469865765419 no 2215 0.355783360984673 703 3534688 SGTC_7 0192-1582 4.227 µM -0.370267919291356 0.346269653281831 no 2216 0.355591437266 708 252616 SGTC_1924 st058459 75.1 µM -0.37084341584962 0.346046045178935 no 2217 0.355377081101596 701 688683 SGTC_1098 clofazimine 15.1 µM -0.37218304372028 0.345525743285725 no 2218 0.354878284945087 692 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2098 5376439 882.5 nM -0.372428977338246 0.345430256089579 no 2219 0.354786741173514 700 2844116 SGTC_1985 st071382 65.5 µM -0.372870067779553 0.345259021148367 no 2220 0.354622575263443 735 6123237 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.37342505721997 0.345043614676263 no 2221 0.354416056558045 684 6312947 SGTC_522 1273-0010 11.6 µM -0.374082145728198 0.34478864569249 no 2222 0.354171600810929 703 5705015 SGTC_1372 2752-0194 270 µM -0.374401224317326 0.344664859560644 no 2223 0.354052916101416 715 823334 SGTC_2464 5717415 7.67 µM -0.375285013177466 0.344322081656118 no 2224 0.353724255390409 708 5285744 SGTC_838 0109-0203 71.4 µM -0.375643458993264 0.344183094708322 no 2225 0.353590988705125 695 759422 SGTC_2840 9008771 71.43 µM -0.375752536403413 0.344140804245009 no 2226 0.353550438339846 685 2992978 SGTC_118 0083-0097 135.343 µM -0.379016383901438 0.342876279962089 no 2227 0.352337848683642 712 5207356 SGTC_2995 9067767 71.4286 µM -0.379255546276754 0.342783689381149 no 2228 0.352249053523943 726 11673567 SGTC_2496 diffractaic acid 79.83 µM -0.379917547407279 0.34252744803692 no 2229 0.352003310654879 698 94870 An apoptosis inducer which activates caspases. SGTC_2620 irigenin 100 µM -0.381425676054412 0.341943966096487 no 2230 0.351443705864863 698 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_438 sphingosine 6.67 µM -0.386232133539472 0.340086912263096 no 2231 0.349662378752715 700 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_480 am 92016 50 µM -0.388723296596548 0.339125931240646 no 2232 0.348740423463794 762 2129 K+ channel blocker. SGTC_3064 1327-0027 10 µM -0.389393491786237 0.338867577680923 no 2233 0.348492542850631 692 16000455 YPR107C YTH1 SGTC_942 3253-1115 227 µM -0.390170641627005 0.338568089054805 no 2234 0.34820518463007 749 46497897 SGTC_1138 3761-0006 1.03 µM -0.390388031934891 0.338484332061051 no 2235 0.348124818173964 723 12061087 SGTC_3235 9132602 49.47 µM -0.390734898235822 0.338350706591978 no 2236 0.347996600199725 722 4912240 SGTC_1808 st050063 61.5 µM -0.391571531049871 0.338028489096589 no 2237 0.347687413189544 751 4011993 SGTC_1972 st070201 17.4 µM -0.391883357283803 0.337908423892553 no 2238 0.347572200216143 710 2829099 SGTC_601 0986-0029 62.9 µM -0.393125409505694 0.337430349324794 no 2239 0.347113428894884 720 24747981 SGTC_2304 7443016 91.4 µM -0.395016877466835 0.336702814173888 no 2240 0.346415216174447 723 939854 SGTC_169 k015-0017 16.025 µM -0.395068350319562 0.336683024154983 no 2241 0.346396222867133 775 1840002 SGTC_1134 3477-0009 42.5 µM -0.396397120479808 0.336172302076803 no 2242 0.345906045005731 741 3973534 SGTC_521 r062-0005 13.8 µM -0.396761251218037 0.3360323986096 no 2243 0.345771763697997 712 2832033 SGTC_3274 9138298 49.47 µM -0.396796894248716 0.336018705342953 no 2244 0.345758620579869 719 17015756 SGTC_1677 st019204 53.9 µM -0.399609033652031 0.334939030607834 no 2245 0.344722250876778 714 3945625 SGTC_3157 9099274 49.47 µM -0.399959779019903 0.334804463090582 no 2246 0.344593070694808 721 17217662 SGTC_2187 6125751 200 µM -0.401169827607259 0.334340376856861 no 2247 0.344147546690416 721 874498 SGTC_1127 asiatic acid 681.4 nM -0.402495679885408 0.33383216735646 no 2248 0.34365963355695 710 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2450 5739737 12.93 µM -0.40260125555399 0.333791712464201 no 2249 0.343620792930762 721 2262825 SGTC_1826 st055655 41.6 µM -0.403326318019739 0.333513932445181 no 2250 0.343354091618241 701 676168 SGTC_3213 9129884 49.47 µM -0.403622908552958 0.333400331389369 no 2251 0.34324501854073 736 17190742 SGTC_2293 7624732 200 µM -0.403644575258166 0.33339203313726 no 2252 0.343237050982084 725 894453 SGTC_2671 danthron 100 µM -0.405342149935998 0.332742123295359 no 2253 0.342613013909702 720 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1772 st048439 82.2 µM -0.405403968702351 0.332718465688972 no 2254 0.342590297108561 707 2927068 YDL195W SEC31 SGTC_233 rapamycin 362 pM -0.406482969622943 0.332305646984245 no 2255 0.342193883871675 711 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_551 k048-0028 34.9 µM -0.407236268207185 0.33201756038455 no 2256 0.341917233158362 748 6836383 SGTC_1100 amiodarone 5.07 µM -0.407243777814734 0.332014688958662 no 2257 0.341914475663922 708 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1828 st055811 49 µM -0.407847989820091 0.331783690585256 no 2258 0.341692639353603 751 5877589 SGTC_2621 lithochol-11-enic acid 100 µM -0.407999187556934 0.331725895656397 no 2259 0.341637135684165 752 6708711 SGTC_564 3555-0129 330 µM -0.409125866540195 0.331295351836526 no 2260 0.341223647315487 713 563260 SGTC_254 nsc-64875 3.808 µM -0.409215340758628 0.331261170124714 no 2261 0.341190818662634 737 56993 SGTC_1994 st072947 40.9 µM -0.409275864650852 0.331238049063056 no 2262 0.341168612747855 759 5286565 YDL195W SEC31 SGTC_2508 celastrol 40.54 µM -0.410591066648234 0.330735780602724 no 2263 0.340686207643417 687 122724 Celastrol is a natural product and antioxidant. SGTC_1562 morin hydrate 59.1 µM -0.41417484183014 0.329368704393865 no 2264 0.339373032554031 744 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1172 0370-0043 85 µM -0.414209281724084 0.329355577884046 no 2265 0.339360422435687 731 376585 SGTC_272 doxorubicin 8.13 µM -0.415044441921566 0.32903732719739 no 2266 0.339054684815068 703 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2885 9057732 51.95 µM -0.415672807230063 0.328797960546993 no 2267 0.338824721048822 735 6471414 SGTC_1447 4239-0816 81.9 µM -0.416123418558558 0.328626349918076 no 2268 0.338659847137455 740 1341554 SGTC_567 1080-0542 68.4 µM -0.417316351416161 0.328172208414058 no 2269 0.338223514960622 699 5950415 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.417423618932304 0.328131384823071 no 2270 0.338184290973372 722 5379071 SGTC_3322 9139058 2.11 µM -0.418464439022458 0.327735378888622 no 2271 0.337803790639985 716 4908926 YPR165W RHO1 SGTC_3080 9117754 49.47 µM -0.419471309172895 0.327352474327433 no 2272 0.337435859305504 753 9550191 SGTC_3031 9088762 49.47 µM -0.420013345244539 0.327146417560277 no 2273 0.337237852342223 732 205253 SGTC_3210 9128157 49.47 µM -0.422377180097764 0.326248414528174 no 2274 0.336374865825121 735 17590849 SGTC_2092 5303694 80.6725 µM -0.422481214594148 0.326208915691717 no 2275 0.33633690476908 727 1963699 SGTC_483 fpl-64176 144 µM -0.42298336022823 0.326018293191708 no 2276 0.336153700757347 730 3423 SGTC_3003 9075612 71.4286 µM -0.423393047570245 0.325862803006654 no 2277 0.336004258269606 761 6501993 SGTC_3093 9117344 49.47 µM -0.423469055149232 0.325833958892456 no 2278 0.335976535679787 694 24824913 SGTC_759 3486-0358 89.3 µM -0.424383155134914 0.325487148809661 no 2279 0.335643201767917 770 875103 SGTC_1830 st055982 50.3 µM -0.424500577467468 0.325442609647299 no 2280 0.335600392135536 770 455313 An antimicrobial agent. SGTC_2839 9003951 25.97 µM -0.42485074933022 0.325309801663435 no 2281 0.335472739751041 743 2990634 SGTC_2723 salbutamol 83.58 µM -0.425208646076927 0.325174086822356 no 2282 0.335342290943784 748 9884233 β2-adrenoceptor agonist SGTC_2007 4011539 71.82 µM -0.425296484788873 0.325140781829114 no 2283 0.335310277884943 732 45595301 SGTC_746 1095-0025 46.6 µM -0.42616764890833 0.324810546241632 no 2284 0.334992844517462 747 6749286 SGTC_1962 st076595 64.5 µM -0.426444338636253 0.324705689171959 no 2285 0.334892049409069 726 279619 SGTC_344 k064-0035 6.43 µM -0.426737026792537 0.324594784298343 no 2286 0.334785439188191 734 5088750 SGTC_1502 4534-4282 27.7 µM -0.427009874692975 0.324491411264699 no 2287 0.334686067674356 750 3278949 SGTC_57 miconazole 162.5 nM -0.427134158401363 0.324444328765282 no 2288 0.334640807244589 731 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2626 ethyl orsellinate 100 µM -0.427142089966264 0.324441324139278 no 2289 0.334637918886129 727 75653 A natural product. SGTC_397 arbidol 50 µM -0.428915771800748 0.323769707439147 no 2290 0.333992261000651 713 131410 A RNA synthesis inhibitor. SGTC_1484 3473-2379 286 µM -0.429041565274042 0.323722096637 no 2291 0.333946488129689 733 671917 SGTC_1319 1306-0155 43.7 µM -0.42950774694649 0.323545679547489 no 2292 0.33377687866845 712 3122360 SGTC_1350 1495-0454 146 µM -0.429788976120364 0.323439273189163 no 2293 0.333674576332281 727 1069057 SGTC_2288 7946289 167.31 µM -0.430588798891541 0.3231367298024 no 2294 0.333383693550956 754 1246052 SGTC_3225 9130819 49.47 µM -0.432871924920505 0.322273751593999 no 2295 0.332553908588687 770 4547121 SGTC_2143 5623677 140.463 µM -0.433039585091094 0.322210416905023 no 2296 0.332493006025662 703 5375313 SGTC_823 0417-1665 178 µM -0.433244467928697 0.32213302812629 no 2297 0.332418588330654 768 3429856 SGTC_2314 7727897 200 µM -0.436412853368188 0.320937242243825 no 2298 0.331268607493836 710 900724 SGTC_1947 st076332 61.6 µM -0.437049867842607 0.320697049067672 no 2299 0.331037591558899 741 24208416 SGTC_3188 9110789 49.47 µM -0.437097858768659 0.320678956610377 no 2300 0.331020190054918 739 849217 SGTC_366 0181-0206 4.31 µM -0.437100312206837 0.320678031681857 no 2301 0.331019300448339 753 274874 SGTC_2019 4016004 108 µM -0.439068554147309 0.319936377772551 no 2302 0.330305931776309 733 45595336 SGTC_1161 k007-0610 110 µM -0.440412314862974 0.319430447706254 no 2303 0.329819253613711 758 5843850 SGTC_2891 9063876 19.48 µM -0.440531148114588 0.319385722775148 no 2304 0.32977622888414 744 6472478 SGTC_2222 6885208 172.143 µM -0.442490426465027 0.318648694009302 no 2305 0.329067178245749 713 609514 SGTC_2748 diazoxide 86.69 µM -0.445622380375198 0.317472025311766 no 2306 0.327935020687075 719 3019 A potassium channel activatior. SGTC_358 0075-0058 9.45 µM -0.445701111786657 0.3174424697666 no 2307 0.327906580690756 804 1069125 SGTC_2110 5483698 200 µM -0.446094572683091 0.317294783123428 no 2308 0.327764466526538 725 2848765 YHR062C RPP1 SGTC_3042 9091578 49.47 µM -0.446355731656305 0.317196772434354 no 2309 0.32767015227236 719 25236497 SGTC_926 2268-1401 59.4 µM -0.446642858217454 0.317089031131193 no 2310 0.327566472840585 753 2931578 SGTC_1344 1488-0097 29.1 µM -0.447411626219631 0.31680063515466 no 2311 0.327288941461172 750 747966 SGTC_2151 5563267 85.4165 µM -0.447805701311244 0.316652844782108 no 2312 0.327146714203754 750 5310824 SGTC_4 0960-0234 25.671 µM -0.448117859537637 0.31653579654225 no 2313 0.32703406971069 718 6821112 SGTC_2158 5657123 3.6195 µM -0.449196481411306 0.316131493148956 no 2314 0.326644962752679 785 2858827 SGTC_735 3076-0345 636 µM -0.449487984698094 0.316022265712472 no 2315 0.326539836869033 719 2888990 SGTC_1775 st081588 35.1725 µM -0.450873033887406 0.315503501834489 no 2316 0.326040529891855 767 1426443 YGL099W LSG1 SGTC_2853 9015042 58.44 µM -0.452469837686211 0.314905877224512 no 2317 0.32546527276163 721 6457456 SGTC_3312 9133330 71.43 µM -0.45589252423384 0.313626525343126 no 2318 0.32423363279227 759 17617324 SGTC_524 r073-0010 27.8 µM -0.456979596304993 0.31322066076211 no 2319 0.323842855553041 758 2772106 SGTC_1778 st046819 58.9 µM -0.457516084571499 0.313020443108094 no 2320 0.323650071945603 752 671715 SGTC_1232 0279-0259 161 µM -0.459284352455331 0.312360915300412 no 2321 0.323014991464061 733 1560000 SGTC_3095 9117207 49.47 µM -0.459495647892869 0.312282146554404 no 2322 0.322939138315807 737 17015229 SGTC_873 0591-4978 488 µM -0.460254824876148 0.311999204059266 no 2323 0.322666661437268 779 3305145 SGTC_94 0334-0113 514.748 µM -0.460958775684295 0.311736943231304 no 2324 0.322414090886866 738 6795178 SGTC_1979 st071809 45.3 µM -0.461048938483267 0.311703359467051 no 2325 0.322381747288906 776 4976333 SGTC_12 0849-0099 9.267 µM -0.461160373650997 0.311661854352413 no 2326 0.322341774630485 764 6071388 SGTC_2809 7964133 12.99 µM -0.461485822769326 0.311540651354249 no 2327 0.322225045270383 767 1253665 SGTC_1818 st052136 56.3 µM -0.462510340637967 0.31115923616867 no 2328 0.321857694294908 743 674169 SGTC_643 k048-0106 28.4 µM -0.462646934564748 0.31110839926355 no 2329 0.321808730337983 740 6763920 SGTC_1780 st038448 24.544 µM -0.462883410509556 0.31102039724406 no 2330 0.321723969624421 772 728868 YDL195W SEC31 SGTC_114 0364-0001 490.298 µM -0.46371410567474 0.310711348499165 no 2331 0.321426294866755 735 4003655 SGTC_1288 0973-0013 65.5 µM -0.463787805306678 0.310683936006817 no 2332 0.321399890568823 736 4315430 SGTC_2829 7992743 58.44 µM -0.464436401822928 0.31044273662468 no 2333 0.32116755743732 755 16462845 SGTC_2968 9090663 33.37 µM -0.464559375478501 0.310397014499063 no 2334 0.321123515052038 762 25236811 SGTC_1253 0550-0034 176 µM -0.465978834593591 0.309869465820472 no 2335 0.320615325300678 718 5969915 SGTC_891 0929-0073 133 µM -0.466370984973559 0.309723790216251 no 2336 0.320474988208873 770 5603632 SGTC_1835 st008666 49.2 µM -0.467556509391154 0.309283574651522 no 2337 0.320050886056093 734 690455 SGTC_2603 homopterocarpin 100 µM -0.468225405061207 0.309035317264491 no 2338 0.319811703145103 736 101795 A weak amylase inhibitor. SGTC_1953 st076800 12.1 µM -0.468251974285498 0.30902545802542 no 2339 0.319802204099831 760 297591 SGTC_2355 9061122 103.12 µM -0.469541029275063 0.308547284190818 no 2340 0.319341482428537 753 5302957 SGTC_384 k007-0144 5.16 µM -0.469772059541859 0.308461617983073 no 2341 0.319258939247969 731 6824886 SGTC_1143 3454-2408 5.08 µM -0.469803964974825 0.308449788242316 no 2342 0.319247540683927 748 X1143 SGTC_905 2-aminofluorene 215 µM -0.469899755934874 0.308414272532411 no 2343 0.319213319344858 724 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1235 benzylparaben 21.5 µM -0.470418242042495 0.308222068372535 no 2344 0.319028116821009 766 7180 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.470641734184538 0.308139235460284 no 2345 0.318948299663709 739 16725076 SGTC_3341 9147222 25.867 µM -0.471894089614905 0.30767525573183 no 2346 0.318501193488425 763 1939759 SGTC_1665 st014639 11.4 µM -0.472690659768541 0.307380297822526 no 2347 0.318216945628 747 981133 YIL048W NEO1 SGTC_2205 7238770 200 µM -0.47284204619049 0.307324255791244 no 2348 0.318162937038027 738 279867 SGTC_1393 3470-5649 58.2 µM -0.473325627532404 0.307145268024162 no 2349 0.317990440556861 753 4108395 SGTC_2240 6690706 185.951 µM -0.474418709189337 0.306740855479591 no 2350 0.317600677032823 717 805876 SGTC_2050 5263056 171 µM -0.474430644432714 0.30673644103852 no 2351 0.317596422360576 744 763468 YGL055W OLE1 SGTC_828 2074-0507 139 µM -0.475118446288853 0.306482093866775 no 2352 0.317351275658895 747 X828 SGTC_2693 st077581 40.7 µM -0.475728487796736 0.306256580229359 no 2353 0.317133911365181 756 25238761 SGTC_1114 scopoletin 1.73284 µM -0.476102765255115 0.306118257646877 no 2354 0.317000583531502 753 5280460 A coumarin with genotoxic properties. SGTC_2953 9074162 66.49 µM -0.47658167163153 0.305941307421892 no 2355 0.316830018672883 735 16451992 SGTC_1009 4106-0057 9.87 µM -0.477725143198709 0.30551899143949 no 2356 0.316422923138531 770 2928005 SGTC_2794 7785382 27.27 µM -0.479932686751736 0.30470441590262 no 2357 0.315637628952192 777 2205081 SGTC_1476 4112-3294 3.34 µM -0.482023291980242 0.303933881741266 no 2358 0.314894700087304 754 704369 SGTC_2084 5306078 60.6385 µM -0.482080445841684 0.3039128287546 no 2359 0.314874400076479 756 679340 SGTC_15 0266-0086 27.098 µM -0.482172408556201 0.303878955071714 no 2360 0.314841737768936 769 1712902 YIL048W NEO1 SGTC_2917 7979103 53.79 µM -0.482968222402761 0.303585894184055 no 2361 0.314559149858588 764 2980565 SGTC_696 1560-0013 611 µM -0.483194169425203 0.303502711507243 no 2362 0.314478937443695 746 1650269 SGTC_1267 0828-0272 9.49 µM -0.483591300737899 0.303356531797905 no 2363 0.314337974903592 751 745334 SGTC_597 k018-0003 82.8 µM -0.484191217348055 0.303135768716895 no 2364 0.314125084660446 780 6786234 SGTC_1765 st044815 90.4 µM -0.485074092967233 0.302811010415485 no 2365 0.313811894243701 748 645695 SGTC_2486 5283202 22.39 µM -0.485564610222354 0.302630645160571 no 2366 0.313637946578436 747 1377751 SGTC_2465 5809242 33.21 µM -0.487214364466669 0.302024377145912 no 2367 0.313053213406703 776 2731748 SGTC_1074 carmofur 3.8 µM -0.489160415914144 0.30130992499383 no 2368 0.312364065730208 769 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2156 5649887 115 µM -0.48943394878489 0.301209564143608 no 2369 0.312267253106277 746 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2998 9066762 71.4286 µM -0.49046992885975 0.300829593436116 no 2370 0.311900701920912 764 4945196 SGTC_133 0724-0033 378.92 µM -0.491034662219755 0.300622554941225 no 2371 0.311700965971866 745 280309 SGTC_2635 hydroquinidine 100 µM -0.491629281491368 0.300404629436137 no 2372 0.31149071977219 760 442912 An experimental heart treatment. SGTC_85 0868-0259 160.055 µM -0.492072637687732 0.30024218768638 no 2373 0.311333997342119 754 83173 SGTC_3260 9137109 49.47 µM -0.492363494063172 0.300135642083844 no 2374 0.311231200797266 763 17478346 SGTC_2919 7978188 46.38 µM -0.492367703878742 0.300134100082845 no 2375 0.311229713042129 711 2980291 SGTC_1904 st060225 78 µM -0.492942408599461 0.299923626815804 no 2376 0.311026640486136 726 66595 SGTC_3272 9137413 49.47 µM -0.493270312960956 0.299803568820941 no 2377 0.310910800882504 790 17614870 SGTC_3318 9139014 38.6185 µM -0.493643953218577 0.299666791743221 no 2378 0.310778826880617 772 16643984 SGTC_3198 9112019 49.47 µM -0.494410630124045 0.299386225776693 no 2379 0.310508104076613 813 45595555 SGTC_641 4092-0595 30 µM -0.497439937639273 0.298278815591241 no 2380 0.309439424030233 747 786260 SGTC_3293 9120939 62.045 µM -0.499029462392786 0.297698487309439 no 2381 0.308879314231947 780 934087 SGTC_2648 atorvastatin 78.68 µM -0.500475038600591 0.297171161729081 no 2382 0.308370313972473 777 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_179 1273-0063 6.77 µM -0.500605129931991 0.297123727216684 no 2383 0.308324525698512 788 3108139 SGTC_2810 7959871 45.46 µM -0.501277201416127 0.296878728512129 no 2384 0.308088024059774 748 2974535 SGTC_2301 7769476 200 µM -0.502798315911973 0.296324559131216 no 2385 0.307553038901353 760 977820 SGTC_1524 corynanthine 62.1 µM -0.503158535414821 0.296193394179787 no 2386 0.307426407389164 783 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2428 5615643 7.78 µM -0.504762391946482 0.295609713367731 no 2387 0.306862866635819 783 2253075 SGTC_1446 4239-0190 62 µM -0.505388655165467 0.295381945198705 no 2388 0.306642942736855 772 1340085 SGTC_1209 2323-2347 50.3 µM -0.505428680599726 0.295367390934244 no 2389 0.306628889431643 743 5412760 SGTC_1518 st038567 90.8 µM -0.505934998565147 0.295183309355551 no 2390 0.30645114099747 777 77966 SGTC_1420 4'-methoxyflavone 42 µM -0.506435688316872 0.295001325980616 no 2391 0.306275413179479 765 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_592 k241-0073 46.5 µM -0.506798048310925 0.294869652927822 no 2392 0.30614826294786 783 4230158 SGTC_1079 idarubicin 2.36 µM -0.508887263777275 0.294111010310406 no 2393 0.305415623899698 780 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.509507393182007 0.293886000667878 no 2394 0.305198308735633 784 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_3247 9135149 49.47 µM -0.511164711178132 0.293285045434637 no 2395 0.304617863272374 768 8934436 YOR116C RPO31 SGTC_1874 staurosporine 7.6 µM -0.511429565303903 0.293189060263857 no 2396 0.304525148456256 789 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_604 1000-0114 314 µM -0.51194880487513 0.293000926132072 no 2397 0.304343419936151 775 1572745 SGTC_3074 9116018 49.47 µM -0.513787054900847 0.292335330448925 no 2398 0.303700439735676 805 17027303 SGTC_2481 5478948 45.16 µM -0.516629440336201 0.291307542754592 no 2399 0.302707430096684 750 77792 SGTC_2949 9072542 2.23 µM -0.517110070698515 0.29113391683979 no 2400 0.302539661977202 788 16457352 SGTC_757 1066-0008 322 µM -0.521919996081976 0.289399017101142 no 2401 0.300863017603691 755 6842497 SGTC_1088 bifonazole 369 nM -0.522486090050626 0.289195151628791 no 2402 0.300665964444733 767 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1028 k015-0029 4.8 µM -0.522557559772042 0.289169418284816 no 2403 0.300641090500949 781 4588309 SGTC_1619 st003326 88.7 µM -0.523077417066148 0.28898227119092 no 2404 0.30046019007717 730 2849032 SGTC_1935 st074532 41.6 µM -0.523253490519278 0.288918898187535 no 2405 0.300398931022176 772 2829742 SGTC_1177 0983-0204 23.6 µM -0.523615895492821 0.28878848064661 no 2406 0.30027286171384 765 766818 SGTC_2789 5281112 71.43 µM -0.525694477795964 0.288041003622795 no 2407 0.299550250628738 762 765948 SGTC_1865 st057639 52.2 µM -0.530319259733396 0.286381174387265 no 2408 0.297945297715639 763 688818 SGTC_460 trequinsin 123 µM -0.530747123465464 0.286227844278567 no 2409 0.297797013102398 780 5537 A vasodilator. SGTC_1196 1588-0294 184 µM -0.531581666135999 0.285928888117719 no 2410 0.297507882784441 790 6144269 SGTC_1853 st056710 91.2 µM -0.53201327652203 0.285774331652526 no 2411 0.297358400111944 772 269167 SGTC_2842 9000675 19.48 µM -0.5329821116756 0.285427543776845 no 2412 0.297022981607569 760 2989072 SGTC_39 0986-0283 58.349 µM -0.533115170351561 0.285379931994413 no 2413 0.296976929144736 752 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_605 1315-0399 119 µM -0.534358292634323 0.284935294032947 no 2414 0.296546834436877 770 24020461 SGTC_1991 st073000 8.92 µM -0.534978258695675 0.284713669132894 no 2415 0.296332445653896 789 4301969 YIL048W NEO1 SGTC_1763 st044482 94.5 µM -0.535352131534033 0.284580057196615 no 2416 0.296203192061804 788 88505 SGTC_2174 5790901 200 µM -0.536575791666745 0.284142963998805 no 2417 0.295780334878708 787 786020 SGTC_812 4251-0442 148 µM -0.537032952619396 0.283979747853873 no 2418 0.295622426099977 783 5723007 SGTC_2025 5147754 141 µM -0.537666418232536 0.283753661384584 no 2419 0.295403683689381 763 315777 YLR208W SEC13 SGTC_3337 9144342 33.5465 µM -0.538380266555283 0.28349898933388 no 2420 0.295157273545324 739 17682949 SGTC_3230 9131665 49.47 µM -0.541927664542521 0.282235049423969 no 2421 0.293934169024637 765 15943720 SGTC_2449 5812982 45.77 µM -0.543521595587408 0.28166801527418 no 2422 0.293385363041086 783 776185 SGTC_2731 amoxapine 43.43 µM -0.545094412818736 0.281109031253228 no 2423 0.292844292588098 809 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_659 k018-0002 107 µM -0.546602637431402 0.280573507451569 no 2424 0.292325878366173 774 6797879 YHR007C ERG11 SGTC_2378 9074213 121.43 µM -0.547116039173737 0.280391327099403 no 2425 0.292149506868393 769 657714 SGTC_496 calpeptin 138 µM -0.547779539321588 0.280155969276918 no 2426 0.291921644684502 757 73364 A calpain inhibitor. SGTC_1412 3909-8563 178 µM -0.547925139792014 0.280104334458769 no 2427 0.291871652997087 788 23767530 SGTC_2460 5552655 174.22 µM -0.548862210925562 0.27977212796092 no 2428 0.291550006590735 776 5401989 SGTC_1642 st009582 77.7 µM -0.550629225930968 0.279146213836221 no 2429 0.290943934971369 780 6739311 SGTC_3109 9122853 49.47 µM -0.552617248457243 0.278442828979296 no 2430 0.290262764246121 796 1234709 SGTC_1632 st005650 90 µM -0.552996663993259 0.278308685673111 no 2431 0.290132847256805 771 2759605 SGTC_2206 7254556 146.969 µM -0.554464036089894 0.277790189332341 no 2432 0.289630655945708 764 4398905 SGTC_830 4076-0286 57.8 µM -0.555604577206472 0.277387504862858 no 2433 0.289240600857506 777 6866659 SGTC_3048 9093155 49.47 µM -0.556425787413328 0.277097741602521 no 2434 0.288959907134786 768 25236002 SGTC_1348 1493-0373 93.8 µM -0.557018786610787 0.276888594527626 no 2435 0.288757296790155 805 3010129 SGTC_897 1000-0139 31.4 µM -0.557068226314343 0.276871160947923 no 2436 0.288740407722137 779 6151020 SGTC_180 1486-1293 102.781 µM -0.557100847768668 0.276859658165146 no 2437 0.288729264181041 783 4140536 SGTC_1915 st067105 30.6 µM -0.558058502578566 0.276522079959388 no 2438 0.288402218034219 788 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2001 4023502 57.655 µM -0.559090186935603 0.276158631912449 no 2439 0.288050085778802 772 108941 YCR052W RSC6 SGTC_2849 9019321 12.99 µM -0.559677313568724 0.27595190010826 no 2440 0.287849779639487 753 16489627 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.560588580065317 0.275631186783444 no 2441 0.287539019185675 770 803109 SGTC_3331 9141060 1.957 µM -0.561307279327324 0.275378375365111 no 2442 0.287294040022231 770 4906567 YPR165W RHO1 SGTC_1324 1418-0026 34.4 µM -0.56193401961505 0.275158004836323 no 2443 0.287080487070519 790 1372513 SGTC_98 0074-0023 107.663 µM -0.56196886024264 0.275145756939415 no 2444 0.287068617821711 796 3563821 SGTC_1349 flufenamic acid 69 µM -0.564778643461431 0.274158888707441 no 2445 0.286112167487407 786 3371 A non-steroidal anti-inflammatory. SGTC_816 0325-0417 81.3 µM -0.565174608172406 0.274019956391126 no 2446 0.285977502884791 790 68101 SGTC_822 1487-0950 154 µM -0.565482308981258 0.273912017299011 no 2447 0.285872876973158 761 1958375 SGTC_3146 9095609 49.47 µM -0.565661082439391 0.273849314591128 no 2448 0.285812097920457 782 17173999 SGTC_1034 k072-0165 12.7 µM -0.567799755225773 0.273099750788503 no 2449 0.285085473029504 802 5835461 SGTC_2194 5927483 104.545 µM -0.568319823481484 0.272917630654438 no 2450 0.28490891041657 750 760979 SGTC_2875 9039966 71.43 µM -0.568699554467486 0.272784692587895 no 2451 0.284780025111621 784 6463691 SGTC_1558 st069300 45.6 µM -0.569581287785711 0.272476135060823 no 2452 0.284480861480369 784 24208000 SGTC_2097 5376186 200 µM -0.57021375846024 0.272254912368634 no 2453 0.284266362771893 759 742755 SGTC_615 k087-0205 167 µM -0.571397936188615 0.271840956252247 no 2454 0.283864963877357 794 9642773 SGTC_692 k241-0027 77.8 µM -0.571552057818511 0.271787102590796 no 2455 0.283812741466724 794 3600480 SGTC_2095 5432005 200 µM -0.572406475966168 0.271488645470507 no 2456 0.283523314782967 817 783734 SGTC_2992 9074591 71.4286 µM -0.5728067262348 0.271348890072524 no 2457 0.283387782166196 796 17741321 SGTC_3328 9140624 29.0385 µM -0.573716729027901 0.271031277845113 no 2458 0.283079752958612 799 4904392 SGTC_2214 7179297 48.276 µM -0.573938599944706 0.270953867841526 no 2459 0.283004675667723 766 769744 SGTC_286 k060-0067 22.9 µM -0.574112793985652 0.270893099867955 no 2460 0.282945738108144 771 5985051 SGTC_219 mitoxanthrone 164.414 µM -0.574583975846203 0.270728761128196 no 2461 0.28278634595108 800 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1164 k060-0068 93.7 µM -0.576237771627559 0.270152344736196 no 2462 0.282227238904065 787 5963676 SGTC_2338 7999974 200 µM -0.57682611822483 0.269947429692349 no 2463 0.282028461994027 812 315925 SGTC_882 0843-0131 351 µM -0.578561087571253 0.26934361108506 no 2464 0.281442683654238 781 5425421 SGTC_2771 fluoxetine 41.05 µM -0.578607141243401 0.269327592330957 no 2465 0.281427142537879 798 3386 A selective serotonin reuptake inhibitor. SGTC_405 ebelactone b 50 µM -0.579024950021085 0.269182288592971 no 2466 0.281286169124808 791 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_896 0964-0007 44.5 µM -0.58083902060658 0.268551855356203 no 2467 0.280674476833901 761 6756758 SGTC_444 curcumin 90.4 µM -0.58336516283468 0.26767519811939 no 2468 0.27982375221819 782 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1845 st056753 3.01 µM -0.584610175396381 0.267243667645756 no 2469 0.279404932096475 783 5375839 SGTC_6 0844-0013 19.835 µM -0.587256208180596 0.266327700786944 no 2470 0.278515823701395 813 1584900 SGTC_1481 3346-2004 36 µM -0.587496989402709 0.266244429421279 no 2471 0.278434985910931 814 2770522 SGTC_587 k089-0003 57 µM -0.587539245894723 0.266229816867941 no 2472 0.278420800263679 798 9659696 SGTC_1357 1503-1303 39.5 µM -0.58845784374144 0.265912260486826 no 2473 0.278112510933035 789 292895 SGTC_2165 5727197 32.143 µM -0.590222107595785 0.265302898790231 no 2474 0.277520876234367 793 1361712 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.590488238826951 0.265211040898175 no 2475 0.277431684231021 776 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2096 5468907 200 µM -0.590589850364805 0.265175972906512 no 2476 0.277397633538349 783 759785 SGTC_2701 st077767 14.721 µM -0.593904117997308 0.264033451261272 no 2477 0.276288122293495 782 5721188 SGTC_3036 9090181 49.47 µM -0.594728386762256 0.263749692538194 no 2478 0.276012521837871 802 25236586 SGTC_2333 9017922 200 µM -0.595145776893579 0.263606063199118 no 2479 0.275873015818828 805 3163164 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.596925596548025 0.262994052473902 no 2480 0.27527852847199 788 66535 A nucleotide analog. SGTC_1002 4049-0206 172 µM -0.601531630754951 0.261413595392808 no 2481 0.273742975340324 807 4662749 SGTC_1231 0242-0792 125 µM -0.602127044315363 0.26120964920074 no 2482 0.273544786878531 797 3707635 SGTC_2675 theaflavin digallate 100 µM -0.602540987457563 0.261067910017453 no 2483 0.273407044246914 805 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_831 k061-1017 217 µM -0.602962020030185 0.260923783896709 no 2484 0.273266977793841 800 1240153 SGTC_2444 5485484 36.41 µM -0.603479607561796 0.260746661572852 no 2485 0.273094838768251 814 6790631 SGTC_1636 st007707 68.9 µM -0.60420548952046 0.260498363603861 no 2486 0.272853515848794 817 403051 SGTC_3197 9113331 49.47 µM -0.604784652020436 0.260300340417552 no 2487 0.272661046405096 783 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2261 9010538 184.68 µM -0.605130892270186 0.260181993429792 no 2488 0.272546014743565 833 6457250 SGTC_794 k038-0031 316 µM -0.606296549817167 0.259783768653235 no 2489 0.272158924636854 803 6624242 SGTC_2145 5634607 200 µM -0.606716991920209 0.259640209807207 no 2490 0.272019371838214 809 308662 SGTC_2197 6588183 93.1375 µM -0.608624222767038 0.258989505497278 no 2491 0.271386772516718 794 884136 SGTC_1555 citronellol 128 µM -0.608895262804014 0.258897101223787 no 2492 0.271296932203166 799 8842 A terpine precursor. SGTC_1434 4073-0095 163 µM -0.608900967196243 0.258895156638221 no 2493 0.271295041555494 806 24133745 SGTC_2368 9071271 200 µM -0.609492331503833 0.25869360587728 no 2494 0.271099077072805 809 27209959 SGTC_472 calcifediol 10 µM -0.610049802214099 0.258503681247203 no 2495 0.270914408809152 793 5283731 A vitamin D metabolite. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.610102467686264 0.258485742388139 no 2496 0.270896966041784 819 279621 SGTC_3190 9110366 49.47 µM -0.61099106013587 0.258183168188692 no 2497 0.270602749373105 782 17123768 SGTC_1414 3917-0015 5.4 µM -0.611969084891167 0.25785035382868 no 2498 0.270279105911031 807 6618702 SGTC_129 0088-0017 176.636 µM -0.612001260622683 0.257839408456598 no 2499 0.270268461754813 809 182446 SGTC_33 0986-0033 35.816 µM -0.612628834385798 0.257625971919089 no 2500 0.270060894000596 770 2848082 SGTC_2490 carminic acid 95.39 µM -0.612747612550973 0.25758558603861 no 2501 0.270021617529802 789 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2167 5876490 200 µM -0.613200280428708 0.257431704135755 no 2502 0.269871959689061 819 686534 SGTC_627 1391-0720 175 µM -0.613218834273737 0.257425397879442 no 2503 0.269865826434498 827 997839 SGTC_2040 5100729 123 µM -0.614276137591191 0.257066164282801 no 2504 0.269516434136161 804 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3018 9082602 49.47 µM -0.615387509522089 0.256688841381891 no 2505 0.269149419086649 811 17332089 SGTC_1706 st031321 9.9705 µM -0.616074520539737 0.256455737950111 no 2506 0.268922668779725 800 6103185 SGTC_2607 solasodine 47.35 µM -0.616311051215537 0.256375508417909 no 2507 0.268844623232302 802 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2869 9037858 32.47 µM -0.616727174223699 0.256234394190768 no 2508 0.268707347099746 798 27187042 SGTC_2359 9039622 200 µM -0.617121174216174 0.256100819577691 no 2509 0.26857740166435 807 6463596 SGTC_2981 9013952 38.96 µM -0.61736174146535 0.256019279879887 no 2510 0.268498075530629 785 2996344 SGTC_122 0236-0016 402.397 µM -0.618943954460172 0.255483330190924 no 2511 0.267976640488863 816 6808838 SGTC_309 k408-0051 1.48 µM -0.6190767199397 0.255438384652141 no 2512 0.267932909419123 808 3640463 SGTC_1520 flindersine 88 µM -0.620267863633337 0.255035327717539 no 2513 0.267540724379833 795 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1548 st061468 90.8 µM -0.624523595664801 0.253598003657002 no 2514 0.266141889628085 798 390799 SGTC_3306 9127676 59.7925 µM -0.626046597295294 0.253084663344026 no 2515 0.265642189034881 806 41905287 SGTC_1042 0350-0096 82 µM -0.626546313144624 0.252916349159903 no 2516 0.265478334759003 800 3122515 SGTC_558 k064-0027 21.3 µM -0.628160294431572 0.252373131009359 no 2517 0.264949469034013 785 5088526 SGTC_2699 st077704 54.6 µM -0.628867117423582 0.252135429176185 no 2518 0.264718027570404 806 645852 SGTC_2242 6630449 61.2675 µM -0.629191284456335 0.25202645257165 no 2519 0.264611917016446 788 691249 YDR170C SEC7 SGTC_1468 k284-1086 134 µM -0.629391070964893 0.251959301874908 no 2520 0.264546531085523 810 15996457 SGTC_3241 9133421 49.47 µM -0.630010043370857 0.251751317611618 no 2521 0.264344006608264 835 17018221 SGTC_421 streptovitacin 30 mM -0.631440453245591 0.25127102489682 no 2522 0.263876286267936 821 91467 include heat shock SGTC_3160 9100216 49.47 µM -0.631454661295776 0.251266256651474 no 2523 0.263871642587839 799 17191039 SGTC_221 trifluoperazine 10.304 µM -0.631950931320582 0.251099737628702 no 2524 0.263709470598826 826 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2328 6201408 200 µM -0.632062341434638 0.251062362974644 no 2525 0.263673070794969 841 2890418 SGTC_1186 1319-0216 26 µM -0.635175895803715 0.250019053164956 no 2526 0.262656851071696 820 4565136 SGTC_3209 9113616 49.47 µM -0.635226922788748 0.250001973895324 no 2527 0.262640213297526 818 16649353 SGTC_695 3505-6186 243 µM -0.636055701246213 0.249724659720104 no 2528 0.262370058696993 819 1819379 SGTC_1121 fusaric acid 630.51 nM -0.637426629444509 0.249266297867095 no 2529 0.261923493650372 781 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2793 7325131 81.82 µM -0.637947688874421 0.249092202079141 no 2530 0.261753866446993 797 4176441 SGTC_224 benfluorex 43.875 µM -0.639583461055104 0.248546080274287 no 2531 0.261221718831001 826 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_99 0109-0120 622.8 µM -0.641445643056659 0.247925146204674 no 2532 0.260616593173906 821 759414 SGTC_1946 st076057 65.1 µM -0.642661412797678 0.247520201793618 no 2533 0.260221912210441 816 953009 SGTC_1682 st012968 530 nM -0.644773208658039 0.246817652954888 no 2534 0.259537083086504 791 24207270 SGTC_2300 7976697 71.57 µM -0.644968262995965 0.246752816487413 no 2535 0.259473876373831 800 2236109 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.645934698005891 0.2464317060507 no 2536 0.259160823628764 834 6710655 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.648213430039086 0.245675455435635 no 2537 0.258423458378272 821 676296 Flavone; oxidizing agent. SGTC_960 1222-0186 7.7 µM -0.648248855064372 0.245663708656851 no 2538 0.258412003929896 820 3126296 SGTC_1051 3253-3903 78 µM -0.649158192476587 0.24536227973787 no 2539 0.258118065732641 818 5509239 SGTC_1469 k284-2957 126 µM -0.649277005827605 0.24532290994749 no 2540 0.258079672795891 804 23884841 SGTC_2800 7887935 81.82 µM -0.651637838137185 0.244541333087632 no 2541 0.257317416067144 821 2961002 SGTC_1015 4130-4525 82 µM -0.651874743591692 0.24446297731511 no 2542 0.257240989569066 816 1363237 SGTC_482 fipronil 114 µM -0.652062836023841 0.244400775938807 no 2543 0.257180318721202 817 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_772 k072-0172 35.3 µM -0.653258239021134 0.244005660608938 no 2544 0.25679490506556 792 5861980 SGTC_1439 4092-1168 46 µM -0.653691697047319 0.243862475344124 no 2545 0.256655226801852 830 2886240 SGTC_1293 1000-1278 195 µM -0.654411251113251 0.243624883411728 no 2546 0.256423443832632 835 678847 SGTC_863 0466-0191 129 µM -0.655501485810572 0.243265133528136 no 2547 0.256072465045223 835 765160 YPR165W RHO1 SGTC_1072 oxiconazole 14.9 nM -0.655689659749827 0.243203069956504 no 2548 0.256011911656609 796 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1432 4049-0298 68.4 µM -0.657984593159135 0.242446843766104 no 2549 0.255274015619757 824 741646 SGTC_374 0880-0231 82.3 µM -0.660469424729113 0.241629480772858 no 2550 0.254476316603076 821 6833587 SGTC_3223 9129970 49.47 µM -0.660579198323206 0.241593406274382 no 2551 0.25444110642141 834 17248386 SGTC_203 k066-0004 30.888 µM -0.66299661363867 0.240799721608744 no 2552 0.253666361446469 827 6795412 SGTC_1620 st003704 16.5 µM -0.663087714188909 0.240769839284247 no 2553 0.253637189344072 820 2834414 SGTC_2662 daunorubicin 22.37 µM -0.66501219607778 0.240139052643159 no 2554 0.253021346214741 798 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3004 9076122 71.4286 µM -0.665060805706246 0.240123131557192 no 2555 0.253005801101614 829 44782551 SGTC_533 1222-0222 6.71 µM -0.666002808763303 0.239814711437918 no 2556 0.252704652549135 835 3982874 SGTC_325 2810-4341 181 µM -0.666824375426706 0.239545899790295 no 2557 0.252442160446634 815 774970 SGTC_1715 st032160 10.2275 µM -0.668195870059252 0.239097521786341 no 2558 0.252004285684554 802 5289825 SGTC_2516 gossypol 71.55 µM -0.670189972176851 0.238446416058724 no 2559 0.25136834776099 829 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.670734736270799 0.238268710989748 no 2560 0.251194765012612 806 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_515 4092-1064 102 µM -0.671021475670649 0.238175204157424 no 2561 0.251103424306604 859 717353 SGTC_1239 0337-0584 35.4 µM -0.671356974324781 0.23806582227351 no 2562 0.250996573671971 834 914301 YML130C ERO1 SGTC_729 4092-0585 94.1 µM -0.671518526449872 0.23801316161385 no 2563 0.250945130641731 816 2169061 SGTC_910 3454-3003 490 µM -0.67159079507721 0.237989606494291 no 2564 0.250922119955033 831 820824 SGTC_5 0352-0601 109.883 µM -0.672597666622777 0.237661561376284 no 2565 0.250601643298511 820 762456 SGTC_2571 chrysanthemic acid 100 µM -0.674116609703392 0.237167149902781 no 2566 0.25011859022688 850 2743 An insecticide. SGTC_2982 9019404 25.97 µM -0.674322583456561 0.237100149589956 no 2567 0.250053124668211 796 22333232 SGTC_2734 clemastine 41.6 µM -0.67462814667357 0.237000773412193 no 2568 0.24995602289445 859 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3180 9109287 49.47 µM -0.674881504008619 0.236918393149366 no 2569 0.249875526265116 815 18891271 SGTC_3045 9092950 49.47 µM -0.674977355873971 0.236887230594391 no 2570 0.249845075822517 823 44120432 SGTC_2960 9079389 5.97 µM -0.67725056714149 0.236148844036188 no 2571 0.249123494509712 806 16457355 SGTC_1082 camptothecin 424.86 nM -0.678321355122278 0.235801469450875 no 2572 0.248783980699765 835 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1913 st060213 96.1 µM -0.679654783761897 0.235369285688163 no 2573 0.248361536293119 840 688959 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.679844780526361 0.235307740559929 no 2574 0.248301374431375 831 5377381 SGTC_2940 9060638 45.86 µM -0.680852463719506 0.23498147307811 no 2575 0.247982424725994 819 4027022 SGTC_3132 9126706 49.47 µM -0.682443003716636 0.234466997342828 no 2576 0.247479435649921 846 850858 SGTC_1337 1486-1011 40.3 µM -0.686091851048177 0.233289100107447 no 2577 0.2463275946477 825 X1337 SGTC_2394 5221648 200 µM -0.686329642235771 0.233212452041774 no 2578 0.246252630362959 840 788586 SGTC_284 0988-0104 32.6 µM -0.68658594456208 0.233129852870953 no 2579 0.246171844093058 841 4666532 SGTC_2048 5246248 200 µM -0.686750818425568 0.233076727157665 no 2580 0.246119883508028 817 677046 SGTC_484 loperamide 105 µM -0.688154839746127 0.232624595381928 no 2581 0.245677639626789 805 3955 An opioid-receptor agonist. SGTC_1039 k821-0043 94 µM -0.688206969983416 0.232607817467734 no 2582 0.245661227670052 812 15992768 SGTC_1746 st038117 42 µM -0.688667116226478 0.232459750368068 no 2583 0.245516387184149 824 2898218 SGTC_1952 st077036 64.1 µM -0.689570509410604 0.2321692066041 no 2584 0.245232159120092 836 2937007 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.690589372133231 0.231841768884041 no 2585 0.244911814104655 833 756377 SGTC_2234 tolnaftate 200 µM -0.691531835840128 0.231539113111541 no 2586 0.244615690639437 837 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3336 9143619 71.43 µM -0.691972249969958 0.231397757343647 no 2587 0.244477378016512 832 45595730 SGTC_1333 1482-0047 286 µM -0.694078881260439 0.230722276880911 no 2588 0.243816370930962 841 3811116 SGTC_431 k089-0097 107 µM -0.695792416237692 0.230173654061183 no 2589 0.243279419642741 831 5499420 SGTC_2641 levomentholum 100 µM -0.696622443485202 0.229908166664015 no 2590 0.243019553259611 833 16666 SGTC_1258 0671-0043 57.1 µM -0.696782136362487 0.229857107954193 no 2591 0.242969573561785 848 4298767 SGTC_930 2810-3379 265 µM -0.697395292451513 0.229661122143711 no 2592 0.242777723400811 850 1015764 SGTC_713 1488-1073 324 µM -0.698036987221926 0.229456114662079 no 2593 0.24257703161902 848 3312542 SGTC_820 1582-0060 59.9 µM -0.698253205933921 0.229387060607089 no 2594 0.242509428871312 841 3848840 SGTC_2013 4024628 200 µM -0.698423253555919 0.22933276045786 no 2595 0.242456269104259 853 5230760 SGTC_328 k915-0120 63.5 µM -0.698705342605882 0.229242698775914 no 2596 0.242368097212302 817 6624543 SGTC_2405 ticlatone 3.52 µM -0.699285423217384 0.229057560603678 no 2597 0.242186837429531 829 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1716 st033144 30.6155 µM -0.700677961033966 0.228613461634244 no 2598 0.241752006464387 846 674617 SGTC_661 1304-0007 33.6 µM -0.703277849000276 0.227785618152134 no 2599 0.240941306143691 838 3117130 SGTC_46 0329-0187a 2.197 µM -0.7043236450128 0.227453097355261 no 2600 0.240615622234609 833 46494817 SGTC_1018 4259-0013 28.1 µM -0.704556163700563 0.22737920299544 no 2601 0.240543243374051 840 6801262 SGTC_1956 st077085 54 µM -0.704884683621668 0.227274822533144 no 2602 0.240441001276591 863 24208685 SGTC_1329 1447-1697 50.6 µM -0.705028918850999 0.227229003280656 no 2603 0.240396119810644 833 2840515 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.708187438470622 0.226226941469704 no 2604 0.239414432907515 842 1273210 SGTC_1714 st033236 13.627 µM -0.708230181694469 0.226213398035806 no 2605 0.239401163087516 845 2916566 SGTC_888 0916-0002 6.97 µM -0.711212920077095 0.225269432499618 no 2606 0.238476151725387 827 2802138 YIL048W NEO1 SGTC_2137 5261020 140 µM -0.711768082882165 0.22509398329674 no 2607 0.23830420004544 834 763655 SGTC_3182 9108849 49.47 µM -0.711878673760318 0.225059042292096 no 2608 0.238269954626053 824 17133045 SGTC_1119 parthenolide 318.541 nM -0.713701261638603 0.224483641552793 no 2609 0.237705963052465 866 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_781 4335-2806 94.4 µM -0.715491640271586 0.22391922312714 no 2610 0.237152652312284 874 845254 SGTC_1939 st074455 53.6 µM -0.716765362452508 0.22351817250675 no 2611 0.236759443750512 846 1644229 SGTC_2876 9059903 25.97 µM -0.716861063569297 0.223488056079716 no 2612 0.236729914513919 821 6916095 SGTC_868 0527-0199 213 µM -0.717536973110795 0.223275418127218 no 2613 0.236521415670445 842 2849450 SGTC_1615 st002656 86.5 µM -0.717618546609136 0.223249763278878 no 2614 0.236496259405218 835 1584458 SGTC_1510 1123-0200 71.5 µM -0.717818733974256 0.223186811505742 no 2615 0.236434530321292 856 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2024 5144227 134 µM -0.71811708851388 0.22309300842007 no 2616 0.236342547207559 826 3475211 SGTC_2491 paeonol 100 µM -0.718982461469145 0.222821060970804 no 2617 0.236075863020504 849 11092 Increases levels of cortical cytochrome oxidase. SGTC_2689 tacrolimus 100 µM -0.72106210278213 0.222168297062497 no 2618 0.235435653147747 830 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.721818560720034 0.221931128790318 no 2619 0.235203018238869 801 4000243 SGTC_1540 guanosine 70.6 µM -0.723226822450438 0.221489989242859 no 2620 0.234770271215819 845 6802 Guanosine is a purine nucleoside SGTC_1957 st077035 62.4 µM -0.724536459664198 0.221080194151222 no 2621 0.234368226000011 862 705593 SGTC_1807 st050092 58.9 µM -0.724590551639236 0.221063277710636 no 2622 0.234351628515158 849 5008496 SGTC_2782 7736369 71.43 µM -0.729094561291353 0.219657318239864 no 2623 0.232971910624806 850 2950836 YOL077C BRX1 SGTC_1591 genipin 88.4 µM -0.729099296890515 0.219655842695328 no 2624 0.232970462342036 868 442424 A DNA cross-linking agent. SGTC_2750 bromebric acid 70.15 µM -0.734145922499565 0.218086624746182 no 2625 0.231429903899308 850 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2522 biochanin a 4.94 µM -0.734160248070302 0.218082179513165 no 2626 0.231425538903651 834 5280373 A possible chelator. SGTC_2737 bleomycin 30.5 nM -0.734746932915255 0.217900175733668 no 2627 0.231246815709686 847 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3222 9128301 49.47 µM -0.735173471961437 0.217767908050395 no 2628 0.231116926464566 830 4911358 SGTC_1373 2887-0003 58.5 µM -0.737613004062251 0.217012311508328 no 2629 0.230374825436193 867 776948 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.740765812355506 0.216038039798946 no 2630 0.229417723746491 846 1609 A potent and irreversible inhibitor of serine proteases. SGTC_192 3455-0609 60.9 µM -0.740816030889832 0.216022541940414 no 2631 0.229402496900704 835 3769639 SGTC_2471 5466956 24.79 µM -0.743236823828508 0.215276229183029 no 2632 0.228669156363782 851 724419 SGTC_2213 7173844 200 µM -0.743297097623482 0.215257666324197 no 2633 0.228650914192612 845 892728 SGTC_2218 6965428 192.983 µM -0.743411443466307 0.215222453146257 no 2634 0.228616309086531 844 675684 SGTC_1690 st023502 41.2 µM -0.744883954430519 0.214769287392073 no 2635 0.228170937976816 847 24207482 SGTC_1313 1220-0047 237 µM -0.745859587730671 0.214469341503367 no 2636 0.227876119831598 843 3528706 SGTC_543 3844-1095 191 µM -0.746147829844531 0.214380771810678 no 2637 0.227789059486625 860 4230703 SGTC_1596 piperlongumine 63 µM -0.747569493003134 0.213944241086315 no 2638 0.227359935794858 829 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3250 9135583 49.47 µM -0.747571199176605 0.213943717505971 no 2639 0.227359421066572 847 7699353 SGTC_1727 st034309 9.9045 µM -0.747825249466173 0.213865764392888 no 2640 0.2272827850324 881 870305 SGTC_2049 5262831 67.185 µM -0.747944821750161 0.21382908040622 no 2641 0.227246720260952 858 763417 SGTC_1130 3454-2858 15.9 µM -0.748204912352343 0.213749298982653 no 2642 0.227168284221985 864 715628 YIL048W NEO1 SGTC_3309 9129340 25.759 µM -0.748293549555751 0.213722113948474 no 2643 0.227141557211483 848 17158987 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.748490328593921 0.213661769007578 no 2644 0.227082228243569 852 688803 SGTC_686 1319-0111 510 µM -0.748937111707534 0.21352479381028 no 2645 0.226947555378202 894 4562600 SGTC_1506 4226-2149 212 µM -0.74914704936122 0.213460448598195 no 2646 0.226884289885203 862 991114 SGTC_420 mitomycin C 81.9 mM -0.751106836373546 0.21286032561011 no 2647 0.226294180888068 839 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2907 7721985 69.9 µM -0.754693438741993 0.211764595549651 no 2648 0.225216472132431 841 3267881 SGTC_1771 st048882 4.1505 µM -0.756788490510054 0.211126073805024 no 2649 0.224588294658779 856 4580403 SGTC_2273 7815444 169.05 µM -0.757403836631653 0.210938745594447 no 2650 0.224403979139369 877 2824616 SGTC_2352 9027995 87.8 µM -0.757801366971075 0.210817778304716 no 2651 0.224284951959459 850 2997347 SGTC_2754 granisetron 64.02 µM -0.757908294963429 0.210785247382261 no 2652 0.224252942062548 855 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_257 daunorubicin 18.5 µM -0.758041120446177 0.210744841713663 no 2653 0.224213183121632 842 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1250 0485-0349 40.2 µM -0.758837176440969 0.210502775768043 no 2654 0.223974981845758 857 6842794 YDL195W SEC31 SGTC_504 lovastatin 124 µM -0.760583056353076 0.209972457650216 no 2655 0.223453071595992 864 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2730 imipramine 71.33 µM -0.760601688138527 0.209966802406943 no 2656 0.223447505576829 849 3696 A tricyclic antidepressant. SGTC_1264 0783-0040 158 µM -0.760867865794855 0.209886020170625 no 2657 0.223367996854388 861 2855798 SGTC_2251 lansoprazole 556 µM -0.762813845108848 0.209295990250407 no 2658 0.222787211475706 865 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_675 1309-0189 238 µM -0.763126153727224 0.209201387829091 no 2659 0.22269408190886 837 4246530 SGTC_3085 9117376 49.47 µM -0.76363747592897 0.209046555912509 no 2660 0.222541654955346 857 16480349 SGTC_1387 3342-1166 1.8 µM -0.764024027676868 0.208929550162561 no 2661 0.222426462010579 843 3418228 SGTC_2349 9023730 187.07 µM -0.765459978366301 0.2084952387224 no 2662 0.221998844693896 872 4126287 SGTC_950 1165-0508 94.1 µM -0.766064506056813 0.208312555245607 no 2663 0.221818960544179 863 6148369 SGTC_821 1114-0266 29.2 µM -0.769411868625511 0.207302719105 no 2664 0.220824422517272 855 3123235 SGTC_1751 st044839 27.194 µM -0.771033017144679 0.206814691411607 no 2665 0.220343680751727 839 5291326 SGTC_3347 9188721 44.724 µM -0.772404159092232 0.206402456626199 no 2666 0.219937545654732 857 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_340 k038-0059 454 µM -0.77352429288886 0.206066049240041 no 2667 0.219606078734387 867 23733424 SGTC_3070 9117005 49.47 µM -0.773935222066932 0.205942717324013 no 2668 0.219484549666177 866 8779016 SGTC_800 3448-7362 155 µM -0.774597724752871 0.205743973031783 no 2669 0.219288701090876 869 15991913 SGTC_1208 2323-2347 50.3 µM -0.775428818658262 0.205494814049162 no 2670 0.219043155788569 855 5412760 SGTC_1071 trifluoperazine 6.31 µM -0.77741473977179 0.204900168021021 no 2671 0.218457059474565 884 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_375 3970-0961 9.27 µM -0.778605660242629 0.204544060970359 no 2672 0.218106021888751 848 2898222 SGTC_516 3992-2719 87.3 µM -0.779316286597757 0.204331746220995 no 2673 0.217896711527837 877 5350887 YDR037W KRS1 SGTC_693 4161-2696 114 µM -0.781737839297409 0.2036092417774 no 2674 0.217184329482415 883 805759 SGTC_367 0335-0881 7.1 µM -0.782933485386242 0.203253066416528 no 2675 0.216833086276534 873 23828853 SGTC_191 3914-0123 66.505 µM -0.784378372025033 0.202823140462704 no 2676 0.216409062609252 873 3144412 SGTC_1035 k081-0041 55.2 µM -0.785968243255225 0.202350702684706 no 2677 0.215943046049462 850 731709 SGTC_1233 0325-0408 14.2 µM -0.78610345229687 0.202310555064339 no 2678 0.215903440972073 863 12874 SGTC_1214 0358-0031 63.7 µM -0.789036041944473 0.201440954021692 no 2679 0.215045470719813 908 4301366 SGTC_1563 conessine 56.1 µM -0.789462964768957 0.201314545614352 no 2680 0.214920733743282 871 441082 An anti-amoebic, histamine inhibitor. SGTC_1281 0884-0031 11.8 µM -0.791529982890719 0.200703190974655 no 2681 0.214317393439188 872 1548255 SGTC_48 0382-0018 55 µM -0.79212558489733 0.200527238921284 no 2682 0.214143726640815 856 762596 SGTC_1298 1079-1278 263 µM -0.793332115859219 0.200171090955475 no 2683 0.213792175049062 871 2840950 SGTC_3259 9138485 49.47 µM -0.793941966728374 0.199991217808194 no 2684 0.213614608398442 847 17646153 SGTC_1490 4089-0339 670 nM -0.794207595144349 0.199912902130319 no 2685 0.213537293823622 857 742542 SGTC_2028 5153890 36.43 µM -0.794643682929473 0.199784369625892 no 2686 0.213410400218424 877 2830968 YPR165W RHO1 SGTC_346 4513-0042 7.16 µM -0.794984348240688 0.199683996531946 no 2687 0.213311303402727 857 2827372 SGTC_1553 gossypol 38.6 µM -0.796989409276108 0.199093843554677 no 2688 0.212728591074661 843 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2594 a-mangostin 100 µM -0.797181551369038 0.199037345276064 no 2689 0.212672799436722 874 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.797290009418832 0.199005458075581 no 2690 0.212641310619241 899 4620898 SGTC_2644 guaiazulene 100 µM -0.797582805145707 0.198919390064585 no 2691 0.212556316315312 853 3515 A coloring agent. SGTC_2089 5281248 129.67 µM -0.797603295445279 0.198913367731604 no 2692 0.212550369024963 865 2737878 SGTC_1700 st030840 7.9285 µM -0.798318226882494 0.198703310033586 no 2693 0.212342921707234 873 5499307 SGTC_2778 tioconazole 65.09 nM -0.799651299946636 0.198311990360092 no 2694 0.211956428132205 871 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1259 0671-0132 43 µM -0.800294862765132 0.198123240973835 no 2695 0.211769989406342 868 X1259 SGTC_1887 st057648 70.8 µM -0.801244212815823 0.197845005897434 no 2696 0.211495140058842 871 688672 SGTC_2783 7738165 71.43 µM -0.8019152055258 0.197648494125842 no 2697 0.211301004879429 871 17201110 SGTC_3046 9092212 49.47 µM -0.802573012855185 0.197455958484678 no 2698 0.211110785938208 894 25236637 SGTC_1322 1348-1070 12 µM -0.803894121995525 0.19706962176541 no 2699 0.210729062531678 854 6758089 SGTC_2976 9009005 19.48 µM -0.807518168898247 0.19601217973929 no 2700 0.209684005553244 832 2993148 SGTC_2605 digitonin 300 nM -0.808426447932993 0.195747698073902 no 2701 0.209422565904622 863 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2709 st078560 56 µM -0.809480582615266 0.195441016447487 no 2702 0.209119383670085 889 17250903 SGTC_2424 5537928 59.2 µM -0.810964059599826 0.195009920029427 no 2703 0.208693155311436 873 5382802 SGTC_2934 9036370 36.88 µM -0.811047245328259 0.194985763498492 no 2704 0.208669269797054 853 6462800 SGTC_698 k064-0052 127 µM -0.811050937111787 0.194984691473553 no 2705 0.208668209795012 913 5088751 SGTC_211 3455-0679 143.504 µM -0.811643707795733 0.194812608429686 no 2706 0.20849805189285 861 748649 SGTC_2897 9048598 12.99 µM -0.814927317960491 0.193861041044261 no 2707 0.207556957535497 878 6467404 SGTC_2153 5569715 200 µM -0.815364634754872 0.193734523799334 no 2708 0.207431810685827 873 2054701 SGTC_1365 1672-3266 55.4 µM -0.815871203374403 0.193588034708983 no 2709 0.207286901830528 862 6415873 SGTC_1652 st011932 78 µM -0.816240281116638 0.193481347666303 no 2710 0.207181361275903 879 1551076 SGTC_3124 9127567 49.47 µM -0.816675441195955 0.193355604691204 no 2711 0.207056964817998 884 17592030 SGTC_1022 4477-0945 21.3 µM -0.81831054062268 0.192883575527989 no 2712 0.206589944423655 853 4648966 SGTC_797 k781-0471 270 µM -0.818335951786489 0.192876245257451 no 2713 0.206582691362582 868 23738129 SGTC_2802 7925815 54.55 µM -0.819593538394417 0.192513686219929 no 2714 0.206223929228061 881 1262923 SGTC_1880 MG-132 525 µM -0.819594157817721 0.192513507744474 no 2715 0.206223752611101 870 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2728 chlorpromazine 9.18 µM -0.821496009812253 0.191966001014867 no 2716 0.205681897997621 914 2726 A thorazine and dopamine antagonist. SGTC_1762 st045503 25.4615 µM -0.82261200957488 0.191645170224112 no 2717 0.205364333486354 878 4645554 SGTC_879 0831-1030 162 µM -0.822701684270597 0.191619404549647 no 2718 0.205338828653624 887 1549252 SGTC_305 1682-2595 20.8 µM -0.822887326630388 0.191566071824302 no 2719 0.205286035152774 876 226033 SGTC_1386 3228-0095 33.8 µM -0.823062616575225 0.19151572156563 no 2720 0.205236193103287 875 870181 SGTC_1070 indatraline 8.81 µM -0.823655132364223 0.191345587444617 no 2721 0.205067770037147 881 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3267 9137951 49.47 µM -0.823907235357553 0.191273227057364 no 2722 0.2049961344875 919 16643986 SGTC_2719 novobiocin 32.65 µM -0.824105213342284 0.191216413773519 no 2723 0.204939889092353 904 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1719 st032227 49.2 µM -0.825621405161319 0.190781658792241 no 2724 0.204509444424946 879 3125804 SGTC_2250 alverine citrate 130 µM -0.825818166789092 0.190725283583914 no 2725 0.204453623551888 861 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1252 0493-0875 34.8 µM -0.827519807064738 0.190238164315546 no 2726 0.203971250127009 865 3960963 SGTC_2079 5212404 121 µM -0.830685358094772 0.189334015082064 no 2727 0.203075699987366 854 758462 SGTC_1724 st037281 8.293 µM -0.830834118980609 0.189291590959333 no 2728 0.203033672628038 865 574124 YDL195W SEC31 SGTC_1661 st013063 9.66 µM -0.830878585557801 0.189278910969541 no 2729 0.203021111108195 896 721395 SGTC_404 fumagillin 50 µM -0.831043463377712 0.189231899343083 no 2730 0.202974538243513 877 12015870 A methionine aminopeptidase binder. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.831470435955784 0.189110190034681 no 2731 0.20285396140696 895 521171 SGTC_1179 1021-1431 9.29 µM -0.831832087114496 0.189007138435064 no 2732 0.202751864783679 902 2840958 SGTC_625 k213-0058 121 µM -0.833506119769392 0.188530577779619 no 2733 0.202279673922366 881 3655420 SGTC_1587 estradiol valerate 56.1 µM -0.835403026597101 0.18799146605545 no 2734 0.20174541315026 890 13791 A steroid. SGTC_2962 9082311 13.18 µM -0.838249193696273 0.187184356520121 no 2735 0.200945381822229 891 16459453 SGTC_2457 5731572 11.68 µM -0.838803293900874 0.187027475623759 no 2736 0.200789851007515 876 2865357 SGTC_3145 9085516 49.47 µM -0.838985171028728 0.186975998979328 no 2737 0.200738815529555 892 25236195 SGTC_3350 9150499 3.57 µM -0.839728440986353 0.186765722566006 no 2738 0.200530331831906 889 4910996 YPR165W RHO1 SGTC_3299 9121982 43.1275 µM -0.840135631864009 0.186650587425311 no 2739 0.200416171872883 885 17594604 YPL160W CDC60 SGTC_681 1642-0006 26.6 µM -0.841685455859373 0.186212769443162 no 2740 0.199982020691265 916 4446530 SGTC_617 3770-0098 35 µM -0.842453460713355 0.185996047711633 no 2741 0.199767089695481 889 5962639 SGTC_2755 lomerizine 42.69 µM -0.844140234885403 0.185520609516374 no 2742 0.199295523325452 875 3949 A calcium channel blocker. SGTC_2806 7952793 58.44 µM -0.845063903603975 0.185260581933148 no 2743 0.199037580331563 892 2972490 SGTC_111 0083-0039 52.457 µM -0.850533189511319 0.18372553170469 no 2744 0.197514358086211 861 759313 SGTC_107 0358-0022 2.6945 µM -0.850844383583477 0.183638428595046 no 2745 0.197427901490554 909 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_448 monastrol 171 µM -0.853698705659554 0.182840705692581 no 2746 0.196635975751615 899 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_809 3998-0021 90 µM -0.853798265112977 0.182812920016288 no 2747 0.196608387963475 892 715485 SGTC_2309 7664088 163.95 µM -0.856645815381533 0.182019323879738 no 2748 0.195820328651738 886 704922 SGTC_733 4069-0007 56.1 µM -0.858440706677057 0.181520206346702 no 2749 0.195324579057709 903 5717425 YNL287W SEC21 SGTC_2319 6033012 152.6 µM -0.859155001587408 0.181321816060202 no 2750 0.195127502848865 902 847246 SGTC_1021 4476-0760 85.3 µM -0.859671197625542 0.181178530860073 no 2751 0.194985157998358 910 746768 SGTC_961 1252-1571 372 µM -0.859868749256536 0.18112371343828 no 2752 0.194930698393276 903 6813498 SGTC_1990 st072050 59.8 µM -0.860224147287546 0.18102512232405 no 2753 0.194832748123919 879 17233948 SGTC_980 1473-0395 201 µM -0.862045104601667 0.18052049748134 no 2754 0.194331348895114 892 768876 SGTC_197 4544-0043 41.561 µM -0.863041755350796 0.180244678976812 no 2755 0.19405725484976 899 896523 SGTC_3227 9130768 49.47 µM -0.865544557511417 0.179553206813384 no 2756 0.193369985475225 914 17720899 SGTC_1513 0337-0559 19 µM -0.865616281256324 0.179533415640274 no 2757 0.193350312053013 893 775073 SGTC_2565 isoliquiritigenin 100 µM -0.86843628421154 0.178756361889017 no 2758 0.192577769332454 870 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_621 3584-0052 32.1 µM -0.869138138611698 0.17856329497812 no 2759 0.192385789211928 887 2273927 SGTC_1761 st044296 37 µM -0.872210367530493 0.177719729183856 no 2760 0.19154681232855 901 1826700 SGTC_1901 st060216 58.6 µM -0.872785546138807 0.177562077794352 no 2761 0.191389989649088 883 688792 SGTC_1180 1193-0155 285 µM -0.87297885152598 0.177509114312758 no 2762 0.191337302527411 909 2921347 SGTC_3191 9110352 49.47 µM -0.873062371442048 0.177486233889139 no 2763 0.191314541173546 882 17122424 SGTC_2817 7995342 71.43 µM -0.873601194552735 0.177338667127276 no 2764 0.191167737726253 917 18879975 SGTC_555 4296-0685 37 µM -0.874252631424075 0.177160362465672 no 2765 0.190990344686834 899 2908540 YHR072W ERG7 SGTC_1626 st003712 1.76 µM -0.874331964171768 0.177138656052013 no 2766 0.190968748452595 912 24207035 SGTC_1400 3771-8998 51.5 µM -0.876171867357691 0.176635707315011 no 2767 0.190468303950017 875 670767 SGTC_215 1287-0124 461.5 µM -0.877388447550194 0.176303644151382 no 2768 0.19013784289658 902 5560863 SGTC_2740 felodipine 17.08 µM -0.880536891258687 0.175446118024091 no 2769 0.189284264633477 862 3333 L-type calcium channel blocker SGTC_1796 st049173 110.4 µM -0.881743709824945 0.175118124919436 no 2770 0.188957709031749 896 94134 SGTC_2961 9083290 32.55 µM -0.884818600303135 0.174284180513412 no 2771 0.18812723792064 895 17741490 SGTC_274 sirtinol 40.1 µM -0.885045767067748 0.174222670629841 no 2772 0.188065973860579 886 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1583 clindamycin 39.6 µM -0.885475484525232 0.174106353885887 no 2773 0.187950118074473 915 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2188 6126565 140.678 µM -0.885536147029454 0.174089937620093 no 2774 0.187933766454454 885 874518 SGTC_1189 1431-2119 7.28 µM -0.8903059264728 0.172802238243147 no 2775 0.186650819874427 893 3107275 SGTC_2936 9038235 15.59 µM -0.890680947097916 0.17270125182595 no 2776 0.186550179530548 881 4749415 SGTC_1783 st039459 87.517 µM -0.890748890726674 0.172682959835525 no 2777 0.186531949809151 903 729761 SGTC_113 0099-0221 2.5 µM -0.894786826739522 0.171598072794874 no 2778 0.185450526797078 887 89219 SGTC_2127 5253358 187.912 µM -0.895242061901316 0.171476036837044 no 2779 0.185328852210027 899 20612 SGTC_2364 9055074 200 µM -0.896922569521391 0.171026019655629 no 2780 0.184880117948712 913 6470630 SGTC_2440 5628896 157.78 µM -0.898588119828015 0.170580753945178 no 2781 0.184436044498472 916 5522048 SGTC_2281 7943571 200 µM -0.89882862619506 0.170516518715195 no 2782 0.184371974919781 904 1244024 SGTC_2115 tiliquinol 12.7705 µM -0.899606780067299 0.170308792969655 no 2783 0.184164773884479 902 71208 A bioactive hydroxyquinoline. SGTC_929 2805-0021 398 µM -0.901203354307287 0.169883100208945 no 2784 0.183740103918348 951 3098024 SGTC_3029 9088683 49.47 µM -0.903142750850445 0.169366919632584 no 2785 0.183225068602553 888 25236615 SGTC_2744 captopril 92.04 µM -0.903973933197547 0.169146004569157 no 2786 0.183004611787743 872 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.906886814831336 0.168373268098057 no 2787 0.182233327181653 901 1377 SGTC_1037 k284-1091 78.7 µM -0.907715828348328 0.168153761008122 no 2788 0.182014189530195 898 3334711 SGTC_1521 st012942 49.4 µM -0.908312487551133 0.167995890941695 no 2789 0.181856573370312 885 24207259 SGTC_463 ikarugamyin 104 µM -0.909822708658946 0.167596727968578 no 2790 0.181458008269538 934 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1342 1486-1464 234 µM -0.912068475961576 0.167004285163346 no 2791 0.180866335919053 897 3253938 SGTC_983 1491-0821 12.2 µM -0.9149688112142 0.166241165543199 no 2792 0.180104001853122 901 46495113 SGTC_861 0443-0273 110 µM -0.915166704567867 0.166189179182947 no 2793 0.180052060501247 916 6149169 SGTC_1784 st039334 36.3 µM -0.915362379092652 0.166137786032951 no 2794 0.180000710776971 923 3496984 SGTC_2436 5633522 8.09 µM -0.915744550761041 0.166037439748714 no 2795 0.179900446216867 916 5724242 SGTC_1116 jasmonic acid  1.58368 µM -0.916684177214223 0.165790889883085 no 2796 0.179654079908558 898 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2927 9011802 47.9 µM -0.917378709819858 0.165608802728925 no 2797 0.179472112565205 904 43912568 SGTC_2906 7926292 26.41 µM -0.919321821342418 0.165100060224828 no 2798 0.178963633684629 922 2966319 SGTC_635 k038-0028 24.7 µM -0.921142979389898 0.164624166853844 no 2799 0.178487891785793 921 4035102 SGTC_332 4112-0506 40.9 µM -0.922340389676928 0.164311752085253 no 2800 0.17817552627818 907 2790355 SGTC_44 0929-0055 61.211 µM -0.924174382456711 0.163833993198688 no 2801 0.177697765538972 910 1379590 SGTC_3103 9120822 49.47 µM -0.924264536386639 0.163810531186198 no 2802 0.177674301025753 910 17141819 SGTC_2371 9071574 200 µM -0.92530158551826 0.163540802278059 no 2803 0.177404527128357 930 45596039 SGTC_513 4245-1575 41.7 µM -0.925336432746458 0.163531743779686 no 2804 0.177395466600042 887 719745 SGTC_1122 capsaicin 818.572 nM -0.927334118169139 0.163012992433646 no 2805 0.176876542607495 904 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1229 0139-0193 12.2 µM -0.928716978475509 0.162654523769045 no 2806 0.176517889708561 906 3090752 SGTC_80 0159-0065 512.242 µM -0.92909706067545 0.162556087775992 no 2807 0.176419393812257 897 1548079 SGTC_2152 5568786 200 µM -0.930452569048133 0.162205345680314 no 2808 0.176068405579152 912 5399883 SGTC_1470 k295-0292 231 µM -0.930840833221531 0.162104971943328 no 2809 0.175967951992948 931 5045612 SGTC_335 4077-0256 27.6 µM -0.931318555485945 0.161981527088413 no 2810 0.175844403183802 899 3121989 SGTC_1986 st071812 45 µM -0.933501783960937 0.161418153949472 no 2811 0.175280474897966 924 11838594 SGTC_3326 9140064 16.379 µM -0.938188452426426 0.160213099304356 no 2812 0.174073785841548 921 1868434 SGTC_2264 7948757 110.76 µM -0.93825311776511 0.160196513532993 no 2813 0.174057173304065 898 2971411 SGTC_619 1652-1634 108 µM -0.939158486569524 0.159964416738013 no 2814 0.173824689735289 932 5400454 SGTC_2972 9093619 59.92 µM -0.939992231746312 0.159750875701581 no 2815 0.173610772679977 897 25236256 SGTC_560 2332-1943 155 µM -0.940380971353017 0.159651374460053 no 2816 0.173511089618147 900 21177716 SGTC_2284 7945075 39.21 µM -0.941724363783212 0.159307833938233 no 2817 0.173166888974199 903 1245402 SGTC_1912 st060209 90.8 µM -0.943323097884515 0.158899627194246 no 2818 0.172757832440088 920 688787 SGTC_975 1335-0046 28.5 µM -0.943803111658916 0.1587771986124 no 2819 0.172635135109049 926 16486740 SGTC_2358 9037157 4 µM -0.944676756911361 0.158554532173431 no 2820 0.172411963429167 909 2388925 SGTC_1600 coumarin 106 71.1 µM -0.945419115107125 0.158365487951937 no 2821 0.172222473565356 921 100336 A hepatotoxic, DNA x-linker. SGTC_957 1187-1561 14.1 µM -0.946865477926321 0.157997591274635 no 2822 0.171853665589269 910 1538454 SGTC_2409 alverine citrate 63.97 µM -0.947471602331926 0.157843584515505 no 2823 0.171699260036837 901 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2033 5192550 145 µM -0.948688128709813 0.157534781730783 no 2824 0.171389626768977 876 182073 SGTC_3076 9116187 49.47 µM -0.9497265654251 0.157271499467785 no 2825 0.171125603861174 909 27241210 SGTC_970 1315-0089 19.5 µM -0.9534280507405 0.156335390211295 no 2826 0.170186617287198 900 6811083 YLR033W RSC58 SGTC_774 k060-0086 136 µM -0.955664113046011 0.155771669682829 no 2827 0.169620979435368 925 5911235 SGTC_195 4234-0266 16.654 µM -0.956327963016978 0.155604568716338 no 2828 0.169453283332566 916 2303354 SGTC_990 3985-0011 41.3 µM -0.956362134124248 0.155595970538438 no 2829 0.169444654199785 920 5399565 YGL099W LSG1 SGTC_677 0929-0063 136 µM -0.959408934089884 0.154830590490345 no 2830 0.168676388056465 946 1539583 SGTC_870 0573-2213 57.6 µM -0.959787673907648 0.154735622170451 no 2831 0.168581043571881 895 3916321 SGTC_528 3492-0019 172 µM -0.961357197120056 0.154342477382867 no 2832 0.168186298991901 912 2869262 SGTC_2568 diosmetin 100 µM -0.961987143024681 0.154184870179532 no 2833 0.168028031160361 919 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_157 1348-1695 65.819 µM -0.962520430617952 0.154051529309711 no 2834 0.167894122738944 896 5380510 SGTC_3168 9103419 49.47 µM -0.962881704238586 0.153961241413103 no 2835 0.167803446040427 913 16649256 SGTC_2069 5228469 200 µM -0.963710221389636 0.153754314346319 no 2836 0.1675956141681 938 2835210 SGTC_2094 5332512 191.667 µM -0.965631728116956 0.153275115581023 no 2837 0.167114246518499 925 755774 SGTC_880 0833-0487 87.2 µM -0.966102877846758 0.153157768201917 no 2838 0.166996352321829 918 76075 SGTC_995 3931-2021 34.6 µM -0.966701302351077 0.153008806865522 no 2839 0.166846687938697 940 730143 SGTC_811 0416-0114 265 µM -0.966834132438646 0.152975755494989 no 2840 0.16681347922403 893 6612453 SGTC_1877 wortmannin 25 µM -0.972842927926649 0.151485570236917 no 2841 0.165315686809233 923 312145 A covalent inhibitor of PI 3-kinase. SGTC_2913 7966556 36.57 µM -0.973240883855079 0.151387218835648 no 2842 0.165216797863749 877 2976516 SGTC_3099 9120367 49.47 µM -0.974562122233629 0.151060990663232 no 2843 0.164888755048035 920 24824940 SGTC_407 eburnamonine 100 µM -0.975326926334544 0.150872366104774 no 2844 0.164699059050714 901 3195 SGTC_2841 9004761 38.96 µM -0.976450189292845 0.150595618749845 no 2845 0.164420710165408 914 2991039 SGTC_58 0957-0393 9 µM -0.976758660817613 0.150519677343082 no 2846 0.164344323136584 923 6997992 SGTC_2224 6650123 117.647 µM -0.976817975494013 0.15050507781784 no 2847 0.164329637637838 937 2908370 SGTC_639 0833-0042 114 µM -0.977469500351142 0.150344775654773 no 2848 0.164168385038859 944 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_667 1498-1044 59 µM -0.979001639298112 0.149968254362502 no 2849 0.163789584762759 938 6739982 SGTC_1862 st057513 3.81 µM -0.979160875411772 0.149929158382225 no 2850 0.163750248393995 926 5393163 SGTC_104 0074-0074 590.992 µM -0.979979023846885 0.14972839206614 no 2851 0.163548236494569 914 3943124 SGTC_690 glyoxal 20.3 µM -0.981925079178111 0.149251568440453 no 2852 0.163068379710522 920 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1198 1612-1005 86.7 µM -0.984328547210926 0.14866407018982 no 2853 0.162476998828464 940 6998509 SGTC_1059 3448-6867 171 µM -0.985995374063002 0.14825754384745 no 2854 0.162067691442612 910 3934407 SGTC_2321 7390090 138.78 µM -0.987611608613867 0.147864067411234 no 2855 0.161671449389365 947 649046 SGTC_952 1185-0122 232 µM -0.989190066636736 0.147480463196297 no 2856 0.161285078766724 925 678600 SGTC_2497 7-hydroxyflavone 100 µM -0.989251598822259 0.147465522873208 no 2857 0.161270029294558 927 5281894 SGTC_2779 methotrexate 400 µM -0.989995243187454 0.147285042479134 no 2858 0.161088222032655 916 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_49 0717-0965 32.132 µM -0.990296906094884 0.147211871967604 no 2859 0.161014509190317 933 5889349 YGL099W LSG1 SGTC_1684 st024538 14.6195 µM -0.993386847680487 0.146463787571873 no 2860 0.160260734298599 940 6732859 SGTC_3165 9101544 49.47 µM -0.996648107446588 0.14567699922204 no 2861 0.159467673091338 933 5002184 SGTC_2254 7938975 95.19 µM -0.998023919668779 0.145345934320567 no 2862 0.159133879955555 947 2969277 SGTC_3212 9128307 49.47 µM -1.00004670927426 0.144860105519379 no 2863 0.158643951918484 943 27243542 SGTC_573 3702-0553 84.7 µM -1.00583860261251 0.143475075784629 no 2864 0.15724660730767 924 1222756 SGTC_682 0kpi-0099 17 µM -1.00682434556859 0.143240245848536 no 2865 0.157009596539263 931 1714895 YML126C ERG13 SGTC_285 1486-1325 46 µM -1.00864936490143 0.142806163722208 no 2866 0.156571411824994 922 22310230 SGTC_1428 4049-0204 61.7 µM -1.01004223218773 0.142475468148761 no 2867 0.156237528470087 938 X1428 SGTC_1356 1502-0781 85.8 µM -1.01044703244069 0.142379457392301 no 2868 0.156140582084359 936 567702 SGTC_3034 9090421 49.47 µM -1.01242903765492 0.14190999613789 no 2869 0.155666480141985 910 17173761 SGTC_893 0958-0369 48.9 µM -1.01247823637565 0.141898356188607 no 2870 0.155654723740436 945 6819948 SGTC_2646 retinol 96.75 µM -1.01308550488257 0.141754735472391 no 2871 0.155509660621242 905 445354 A vitamin A analog and teratogen. SGTC_1559 coumarin 343 70.1 µM -1.01572007725503 0.141132792018539 no 2872 0.154881352224066 933 108770 A hepatotoxic, DNA x-linker. SGTC_2850 9015429 58.44 µM -1.01688649912351 0.140858026653078 no 2873 0.154603713312087 940 6457570 SGTC_1732 st034308 51.822 µM -1.01733407582761 0.140752690730744 no 2874 0.154497265724628 903 830119 SGTC_1032 k061-1018 98.7 µM -1.01762008987505 0.140685406125771 no 2875 0.154429268112663 946 4005393 SGTC_717 1532-0246 73.2 µM -1.01820698436675 0.140547407966367 no 2876 0.154289800480772 933 9561992 SGTC_1848 st056003 16.4 µM -1.0182661023946 0.140533512473318 no 2877 0.154275756490645 899 146492 SGTC_3351 9150312 21.596 µM -1.02068564880239 0.139965606330587 no 2878 0.153701697987656 930 4904905 SGTC_2798 7813637 45.45 µM -1.02082048152716 0.139934004880094 no 2879 0.153669749399484 920 956368 SGTC_2521 angolensin 13.4 µM -1.02304626521912 0.139413036995896 no 2880 0.153142985773787 930 821428 A flavenoid. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.02535535537493 0.138873966415194 no 2881 0.152597772698678 925 2333 A French combination drug. SGTC_2438 5259590 200 µM -1.0253697822414 0.138870602846851 no 2882 0.152594370338153 943 1201127 SGTC_2532 xanthone 78.9 µM -1.02586845626555 0.138754373017324 no 2883 0.152476796469844 938 7020 An insecticide. SGTC_1588 farnesol 29.9 µM -1.02728270136758 0.138425104406577 no 2884 0.152143682750007 932 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2045 5106652 78.05 µM -1.02804139992996 0.138248681667494 no 2885 0.1519651769006 918 673349 SGTC_2417 cerulenin 830 nM -1.02840739990426 0.138163629291238 no 2886 0.151879114551595 929 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1316 1272-0050 65.9 µM -1.02882881684778 0.138065743121098 no 2887 0.151780061402162 937 7340392 SGTC_61 0978-8327 98.565 µM -1.03007010445778 0.137777693346584 no 2888 0.151488548901262 931 6150059 YHR072W ERG7 SGTC_2168 5727979 200 µM -1.03204216746645 0.137320905617414 no 2889 0.151026182068848 935 695210 SGTC_2059 5238311 157 µM -1.03418598898132 0.136825508068196 no 2890 0.150524611456168 940 703021 SGTC_2942 9052777 62.25 µM -1.03696542806885 0.136185051666768 no 2891 0.14987598473885 948 6469503 SGTC_105 0111-0055 734.78 µM -1.03769395129855 0.136017520514113 no 2892 0.149706280943325 954 5179370 SGTC_499 genistein 192 µM -1.03905327710775 0.135705307386801 no 2893 0.149389979491992 962 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_218 alverine citrate 93.75 µM -1.04132233953317 0.135185238159105 no 2894 0.148862986029777 925 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1870 st057514 26.5 µM -1.04262784630985 0.134886636014908 no 2895 0.148560343601258 933 5393161 SGTC_3330 9141424 71.43 µM -1.04532464409079 0.134271244276372 no 2896 0.147936475708998 917 27261020 SGTC_656 4090-1979 187 µM -1.04743077043899 0.133791982870297 no 2897 0.147450473088189 938 22330961 SGTC_45 0kpi-0036 14.9 µM -1.04786671927553 0.133692927227157 no 2898 0.147350008791219 950 2795021 SGTC_160 3453-0671 289.699 µM -1.04842919179402 0.133565197573689 no 2899 0.14722045493451 965 5322268 SGTC_2244 6635614 200 µM -1.04916911732468 0.133397298664912 no 2900 0.147050144785179 958 836499 SGTC_949 1165-0505 146 µM -1.05216444585035 0.132719102743581 no 2901 0.146362054293024 941 6244267 SGTC_3264 9137442 49.47 µM -1.05405812364946 0.132291567563353 no 2902 0.145928153492955 937 17015726 SGTC_1187 1391-0724 117 µM -1.05408902616282 0.132284598591704 no 2903 0.145921079936166 950 6997986 SGTC_596 1155-0152 116 µM -1.0545008351666 0.132191753754645 no 2904 0.145826839228792 934 280313 SGTC_1101 ebselen 5.29 µM -1.05506301638797 0.132065079131337 no 2905 0.145698252543748 945 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_715 0868-0130 184 µM -1.05539511619188 0.131990287411924 no 2906 0.145622327786471 975 2876258 SGTC_2636 apigenin dimethyl ether 100 µM -1.05889722297985 0.131203361135205 no 2907 0.144823294567374 950 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_514 4466-0038 2.65 nM -1.0611347966986 0.130702276371752 no 2908 0.14431432312045 905 5722064 SGTC_3134 9127454 49.47 µM -1.06134825872731 0.130654542664026 no 2909 0.144265830887375 960 24262820 SGTC_1832 st054113 55 µM -1.06137691503856 0.130648135547517 no 2910 0.144259321860891 932 1251267 SGTC_1867 st057372 64 µM -1.06540939093211 0.129748700448779 no 2911 0.143345354474572 932 688837 SGTC_3154 9100113 49.47 µM -1.0656843281429 0.129687532824866 no 2912 0.143283182199657 947 25237525 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.06731250797207 0.129325707141753 no 2913 0.142915370896037 970 91467 include heat shock SGTC_3068 9116768 49.47 µM -1.06732939528265 0.129321957993183 no 2914 0.142911559342165 944 41904888 SGTC_2514 salinomycin 42.74 µM -1.06993721820492 0.128743899510018 no 2915 0.14232378449727 956 23682228 A polyether potassium ionophore. SGTC_3025 9087895 49.47 µM -1.07474533458746 0.127682821882514 no 2916 0.141244380420987 953 17173641 SGTC_663 1486-0733 13.9 µM -1.07890513645243 0.126769734754896 no 2917 0.140315009422682 944 722445 YPR165W RHO1 SGTC_276 colchicine 750 µM -1.07903402136142 0.126741516989603 no 2918 0.140286280808998 937 2833 A microtubule depolymerizer. SGTC_2824 7998404 51.95 µM -1.07988155788209 0.126556068238078 no 2919 0.140097463327422 959 837851 SGTC_856 0433-0016 11.3 µM -1.08095764157018 0.126320883723492 no 2920 0.139857978100043 950 3911780 SGTC_3254 9136651 49.47 µM -1.08347468890728 0.125771957880712 no 2921 0.139298889812106 962 16454030 SGTC_2404 5161160 200 µM -1.08503167495588 0.125433239446976 no 2922 0.13895381328345 934 2831543 SGTC_572 0960-0087 17.7 µM -1.08683050759078 0.125042701246013 no 2923 0.13855586123339 963 6796365 SGTC_1268 0828-0275 2.46 µM -1.08688955595938 0.125029895876384 no 2924 0.138542811261008 948 745337 SGTC_531 3788-1495 174 µM -1.08763897694661 0.124867454240358 no 2925 0.138377258396 928 2896655 SGTC_805 3852-0218 479 µM -1.09092703822647 0.124156489606037 no 2926 0.137652494305893 946 6615355 SGTC_2854 9024559 71.43 µM -1.09101641575436 0.124137203469653 no 2927 0.1376328296856 962 3163529 SGTC_3252 9135871 49.47 µM -1.09299988374516 0.123709744413228 no 2928 0.13719692539561 965 17682838 SGTC_3121 9125696 49.47 µM -1.09339047110443 0.123625690162404 no 2929 0.137111197757186 981 1235365 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.09536211314413 0.123202004036177 no 2930 0.136679012746665 935 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1058 3448-5425 97.3 µM -1.09618938681799 0.123024534615195 no 2931 0.136497951602129 948 7279705 SGTC_706 4262-0057 46.9 µM -1.09796572430222 0.122644074689298 no 2932 0.136109728242743 973 883298 SGTC_776 4476-4378 112 µM -1.09881366488098 0.122462752220567 no 2933 0.135924675279204 981 2892008 SGTC_424 splitomicin 100 mM -1.10095786046489 0.122005079879477 no 2934 0.135457498885352 972 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2990 9074105 71.4286 µM -1.10140373707536 0.121910059873562 no 2935 0.135360489847454 959 6502001 SGTC_2063 5246145 200 µM -1.10246517590219 0.121684067654285 no 2936 0.135129745043708 962 711240 SGTC_3141 9094609 49.47 µM -1.10468719685741 0.121211928111934 no 2937 0.13464757650756 951 25236309 YDL196W YDL196W SGTC_79 0052-0007 94.094 µM -1.10585719412588 0.120963843179019 no 2938 0.13439416748848 917 2801472 SGTC_3258 9138477 49.47 µM -1.10602526639002 0.120928234689968 no 2939 0.134357791732972 981 4970355 SGTC_1999 st074831 12.5 µM -1.10647351701801 0.120833302517975 no 2940 0.134260810244109 950 17112523 SGTC_2555 cholic acid 100 µM -1.11165966605501 0.119738773474919 no 2941 0.133142253987247 945 6708657 Influences liver metabolism. SGTC_2123 5259487 200 µM -1.11249133350383 0.119563903849267 no 2942 0.132963477173912 961 2173474 SGTC_2401 5128683 200 µM -1.11639478655519 0.118745555867113 no 2943 0.132126592068481 974 708373 SGTC_2182 6325192 200 µM -1.11874317700576 0.118255132924449 no 2944 0.131624859739989 924 736248 SGTC_1774 st048371 48.465 µM -1.11886467440991 0.118229799198974 no 2945 0.131598937708276 974 4242727 SGTC_3196 9111891 49.47 µM -1.12295077408553 0.117380030250338 no 2946 0.130729200808767 981 18891510 SGTC_20 0481-0013 4.944 µM -1.12403193083224 0.117155912039172 no 2947 0.130499740084502 951 182045 SGTC_3276 9139060 49.47 µM -1.12579561500508 0.116790960363056 no 2948 0.130126020335187 970 4870619 SGTC_1691 st019933 84.6 µM -1.12623023924373 0.116701149321535 no 2949 0.130034038533339 986 6176082 SGTC_2601 securinine 100 µM -1.12877046601922 0.116177214605042 no 2950 0.129497337258318 959 442872 A GABA receptor antagonist. SGTC_410 α-linolenic acid 100 µM -1.12993762872373 0.115937041897048 no 2951 0.129251253429849 959 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1091 telmisartan 47.6 µM -1.1300503118649 0.115913873216054 no 2952 0.129227512558319 979 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2480 5767542 37.17 µM -1.13020208658995 0.115882672145227 no 2953 0.1291955403766 942 2867358 SGTC_1008 4106-0037 6 µM -1.13035275049119 0.115851705330486 no 2954 0.129163807619891 955 2905394 SGTC_2135 5326629 150.42 µM -1.13151860211031 0.115612279819989 no 2955 0.128918439200634 964 5020077 SGTC_2815 7968870 71.43 µM -1.13154651108311 0.115606552595707 no 2956 0.128912569364331 970 2977326 YHR190W ERG9 SGTC_1819 st053448 58.6 µM -1.13538758220901 0.114820244938588 no 2957 0.128106480157648 975 2857616 SGTC_1998 st075797 76.8 µM -1.13587028116951 0.11472170113788 no 2958 0.12800542887636 933 24208315 SGTC_2987 9018338 71.43 µM -1.13849997816041 0.114185901003802 no 2959 0.127455883994767 948 5055682 SGTC_3172 9105863 49.47 µM -1.13960887489503 0.113960498611379 no 2960 0.12722464313368 990 2348785 SGTC_2170 morpholine 200 µM -1.13991977223822 0.113897360301447 no 2961 0.1271598633948 964 121171 Reacts with secondary amines. SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.1422608248443 0.113422730153863 no 2962 0.126672809911059 967 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2247 cerulenin 830 nM -1.14308422355915 0.113256128271658 no 2963 0.126501811925649 939 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3288 9119690 36.221 µM -1.14309779923571 0.113253382908985 no 2964 0.126498993967281 991 17595618 YKL019W RAM2 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.14545140251349 0.112778139129866 no 2965 0.126011107807447 971 140250 A respiratory chain inhibitor. SGTC_9 0092-0002 10.449 µM -1.14770047709688 0.112325334022107 no 2966 0.125546117084582 962 759368 SGTC_1225 1216-0074 20.6 µM -1.1523512183691 0.111393126487241 no 2967 0.12458838897089 967 4241466 SGTC_1713 st033146 12.748 µM -1.15357223442766 0.111149302987167 no 2968 0.12433779355695 981 674619 SGTC_1710 st031758 61.5 µM -1.15478311076369 0.110907881921761 no 2969 0.124089627511995 968 5394341 SGTC_2597 laccaic acid a 100 µM -1.15672043277019 0.110522405881652 no 2970 0.123693299441259 984 5491415 A textile dye. SGTC_1515 3460-0031 42.1 µM -1.15708433117823 0.11045010695868 no 2971 0.123618953830385 955 2876596 SGTC_642 0335-0876 158 µM -1.15948700641931 0.109973597105775 no 2972 0.123128864940286 964 6812350 SGTC_3281 9140613 49.47 µM -1.16005253085358 0.109861654422289 no 2973 0.123013709598367 940 16013766 SGTC_303 1348-1668 34.2 µM -1.16385906903558 0.10911029693483 no 2974 0.122240564700996 968 5380509 SGTC_1488 4013-0813 75.9 µM -1.16524673737239 0.108837311170929 no 2975 0.12195956603407 941 2910057 SGTC_1153 4055-0057 267 µM -1.16569950999881 0.10874834689086 no 2976 0.12186797918064 950 882706 SGTC_1725 st036284 20.55 µM -1.16584968010046 0.108718851855005 no 2977 0.121837613442848 959 707914 SGTC_2872 9044037 25.97 µM -1.16622361437949 0.108645432108059 no 2978 0.121762023685063 966 6465195 SGTC_2534 helenine 20.12 µM -1.16736211332442 0.108422114276287 no 2979 0.121532082248805 959 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3094 9117742 49.47 µM -1.16759457736175 0.108376556829617 no 2980 0.121485169279929 975 17149698 SGTC_2804 7954240 19.48 µM -1.16957321028424 0.107989349130538 no 2981 0.12108638173349 957 828705 SGTC_3058 9093861 49.47 µM -1.17352770500683 0.107218463084697 no 2982 0.12029212671826 956 17217477 SGTC_108 0509-0257 621.132 µM -1.17594911386995 0.106748398606651 no 2983 0.119807605502708 961 536624 SGTC_2332 7982454 138.89 µM -1.17602541739672 0.106733610126142 no 2984 0.119792359648634 978 2981748 SGTC_2217 6934799 96.0675 µM -1.17634563666992 0.106671564156252 no 2985 0.119728393036533 970 675606 SGTC_40 0327-0103 19.753 µM -1.17677375783107 0.106588651694394 no 2986 0.1196429097095 946 409036 SGTC_2487 5918373 44.05 µM -1.17753914991262 0.106440537308029 no 2987 0.119490190493597 976 2876279 SGTC_1154 4088-0362 150 µM -1.17850405908388 0.106254025331098 no 2988 0.119297857539635 966 6618304 SGTC_901 1112-0062 60.1 µM -1.17890998432998 0.106175632650392 no 2989 0.119217010791222 951 1908457 SGTC_2628 lathosterol 100 µM -1.18082177630593 0.105806987247145 no 2990 0.118836765682688 973 6710616 SGTC_1376 2910-0861 41.3 µM -1.1808700032193 0.105797699767686 no 2991 0.11882718469972 985 1112859 SGTC_2882 9058044 58.44 µM -1.1817897916105 0.105620680836905 no 2992 0.118644559684849 959 18076804 SGTC_1790 st045711 43.5 µM -1.1824665967534 0.105490562367265 no 2993 0.118510305977569 909 585119 SGTC_1650 st011916 45.8 µM -1.18275978081978 0.105434232571947 no 2994 0.118452182183544 985 242528 SGTC_877 0771-0151 33.1 µM -1.18321659273663 0.105346508131363 no 2995 0.118361659298612 980 6166523 SGTC_3143 9086658 49.47 µM -1.18418565936988 0.105160587066661 no 2996 0.118169788795969 951 25236626 SGTC_883 0850-0245 24.6 µM -1.1852268050288 0.104961101946861 no 2997 0.117963892209018 957 6823229 YPR165W RHO1 SGTC_510 ag-490 170 µM -1.18730568497534 0.104563605200632 no 2998 0.117553533253255 991 5328779 SGTC_281 1672-3440 14.9 µM -1.18957840994161 0.104130292937472 no 2999 0.11710606789559 974 6833000 SGTC_1753 st043925 64 µM -1.19092841761142 0.103873520823836 no 3000 0.116840843708676 986 670181 SGTC_2537 larixol 68.93 µM -1.19096258540949 0.103867028055945 no 3001 0.116834136589698 963 6708759 SGTC_2196 6573537 42.6665 µM -1.19200745960216 0.103668616975234 no 3002 0.116629160164433 988 2903087 SGTC_2219 9098279 200 µM -1.19289924394992 0.103499493744202 no 3003 0.116454417688597 957 902349 SGTC_2674 ligustilide 100 µM -1.19596658979086 0.102919313245046 no 3004 0.115854798626351 988 5319022 A signalling regulator. SGTC_886 0866-0150 153 µM -1.19856099572802 0.102430435519778 no 3005 0.115349346091275 976 271463 SGTC_2287 7945887 168.79 µM -1.19961776027489 0.102231788478714 no 3006 0.11514391286997 962 1245853 SGTC_3107 9121808 49.47 µM -1.20312870713699 0.101573824785593 no 3007 0.114463258998046 910 662681 SGTC_461 N-acetylfarnesylcysteine 136 µM -1.20407479278916 0.101397053641458 no 3008 0.114280335869202 1015 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2062 5245942 200 µM -1.20659288434078 0.100927653659076 no 3009 0.113794484220341 997 1376160 SGTC_56 0957-0365 83.25 µM -1.20952930302704 0.100382276137479 no 3010 0.113229780156737 969 6752360 SGTC_379 3970-0972 5.9 µM -1.20994008774224 0.10030615338134 no 3011 0.113150941635675 983 2898042 YBL034C STU1 SGTC_1627 st003713 25.6 µM -1.21125341812245 0.100063062045633 no 3012 0.112899147780882 984 16195070 YER133W GLC7 SGTC_1740 st038286 13.222 µM -1.21159303832729 0.100000269986163 no 3013 0.112834100376728 957 716786 SGTC_1149 3909-7961 23.3 µM -1.2130499405177 0.0997312311757502 no 3014 0.112555363711297 972 735261 SGTC_357 1325-0123 420 µM -1.21309817653526 0.0997223327253021 no 3015 0.112546143544524 996 1098503 SGTC_324 1315-0088 19.6 µM -1.21399126389508 0.0995576831570972 no 3016 0.112375530091008 983 6787421 SGTC_913 3487-1245 167 µM -1.2160326408904 0.0991820811532207 no 3017 0.11198624405515 962 4016153 SGTC_1112 tnp00069 1.16933 µM -1.21642442291737 0.099110114119657 no 3018 0.111911642512911 977 145826 SGTC_2216 7189485 200 µM -1.21701431361676 0.0990018282586894 no 3019 0.11179938496934 965 731273 SGTC_132 0417-1715 25.805 µM -1.21842540056789 0.0987431471057972 no 3020 0.111531178724351 982 6769098 SGTC_1401 3807-4679 7.6 µM -1.22035867330437 0.0983895421901915 no 3021 0.111164468250572 969 3291456 SGTC_1675 st018485 24.5 µM -1.22530035890058 0.0974899002572658 no 3022 0.110231036616805 992 3323024 SGTC_2297 7971671 152.32 µM -1.22738407420015 0.0971123702304235 no 3023 0.109839134650341 987 909016 SGTC_3051 9093778 49.47 µM -1.22965911776795 0.0967014016404922 no 3024 0.109412391034076 1010 17217378 SGTC_974 1326-0144 138 µM -1.23219434830255 0.096244938779938 no 3025 0.108938246999346 992 5411856 SGTC_1644 st010134 20.9 µM -1.23375307404799 0.0959650808639153 no 3026 0.108647465137667 977 3818134 SGTC_996 3970-0799 1.8 µM -1.23779382885822 0.0952423799523155 no 3027 0.107896258622042 976 6615648 YGL040C HEM2 SGTC_1040 k898-0338 155 µM -1.23833122587451 0.0951465676438815 no 3028 0.107796635009878 980 20969351 SGTC_1539 benzyladenosine 56 µM -1.23837308586267 0.0951391074235975 no 3029 0.107788877713489 962 92208 A nucleotide analog. SGTC_2316 5844804 197.44 µM -1.23843133829474 0.0951287264849882 no 3030 0.107778083315538 973 776813 SGTC_2164 5685496 200 µM -1.23884069868004 0.0950557994962117 no 3031 0.107702249236502 996 759046 SGTC_1602 st001878 87.6 µM -1.23888927436507 0.095047148538687 no 3032 0.107693253134819 978 595405 YLR310C CDC25 SGTC_2134 5324836 1.464 µM -1.24006931960297 0.0948371696459699 no 3033 0.107474877846662 999 699272 SGTC_1814 st052110 31.539 µM -1.24317459406725 0.0942862463440451 no 3034 0.106901751308217 976 674163 SGTC_2385 9074692 200 µM -1.24500798963317 0.0939620840648201 no 3035 0.106564406694899 986 17046906 SGTC_78 0336-0123 156.75 µM -1.24510551338055 0.0939448639785394 no 3036 0.106546483884581 962 6765896 SGTC_2818 7996756 12.99 µM -1.24551738725277 0.0938721637532166 no 3037 0.106470814145422 1002 2241621 SGTC_1497 4476-2978 41.3 µM -1.24842491771365 0.0933601338318256 no 3038 0.105937744279716 955 1528379 SGTC_378 3970-0959 8.33 µM -1.2499016924664 0.0931008582391937 no 3039 0.105667730551214 1004 6615653 SGTC_3091 9116372 49.47 µM -1.25616295086629 0.0920074864920002 no 3040 0.1045284481567 993 17169793 SGTC_2146 5545642 200 µM -1.2599035585742 0.091358836361573 no 3041 0.103852077430374 984 825326 SGTC_3296 9122258 64.045 µM -1.26013668077637 0.0913185236855261 no 3042 0.103810029973496 979 4730474 SGTC_644 1498-1197 63.3 µM -1.26274285862501 0.0908687476458778 no 3043 0.10334080305367 991 6741615 SGTC_1657 st012939 43.4 µM -1.2677102024634 0.0900160353633504 no 3044 0.102450730006392 973 24207257 SGTC_688 0527-0193 473 µM -1.26949005492485 0.0897119507921479 no 3045 0.10213316766275 1013 4007154 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.27258333705553 0.0891852871819433 no 3046 0.101582967273854 1003 75037 A free radical scavenger. SGTC_2367 9070478 135.38 µM -1.27633784834673 0.0885491376030582 no 3047 0.100918058174119 981 572802 SGTC_273 hydroxyurea 18.1 mM -1.27662039717434 0.0885014007601444 no 3048 0.100868148574059 1006 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1882 5615643 20 µM -1.28510114639617 0.0870774813387891 no 3049 0.0993784705196774 940 2253075 SGTC_3089 9117425 49.47 µM -1.28887242428769 0.0864498073717624 no 3050 0.0987212211206773 1008 9401657 SGTC_1396 3511-0007 98.6 µM -1.30071987290579 0.0844999793711722 no 3051 0.0966771786959123 983 X1396 SGTC_3355 9151058 44.0485 µM -1.30217354334494 0.0842630280779166 no 3052 0.0964285335569736 996 17015728 SGTC_1352 1496-0991 99 µM -1.30531277087518 0.0837530292732575 no 3053 0.0958931835865152 1007 3000039 SGTC_894 0960-0238 55.9 µM -1.31409415460976 0.0823387233619972 no 3054 0.0944072605078244 1000 6741907 YDL195W SEC31 SGTC_1391 3442-0225 151 µM -1.31501721045958 0.0821911093801777 no 3055 0.0942520592188307 998 5227075 SGTC_3102 9121669 49.47 µM -1.31618029196186 0.0820053947124091 no 3056 0.0940567684245815 1022 41905072 SGTC_37 0566-0070 1.56 µM -1.32098794331119 0.0812410880878081 no 3057 0.0932526921774531 983 1626686 SGTC_2912 7964298 10.93 µM -1.32452910758053 0.0806815701012713 no 3058 0.0926636913185554 974 2975850 SGTC_2606 farnesol 9.78 µM -1.32578001311282 0.0804846191984797 no 3059 0.0924562876040406 982 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1616 st002734 56.1 µM -1.32947675359715 0.0799047024618253 no 3060 0.0918453651106464 995 4026101 SGTC_991 3996-0057 64.7 µM -1.33380459364132 0.0792298051015199 no 3061 0.0911339525682625 985 715343 SGTC_2677 mitomycin C 100 µM -1.33431903958464 0.0791498685972272 no 3062 0.0910496601862409 1031 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2107 5363541 170.161 µM -1.33547914976313 0.0789698305614618 no 3063 0.0908597874620136 990 244052 SGTC_1327 1436-0082 2.18 µM -1.33599514788958 0.0788898523118286 no 3064 0.0907754296225224 1007 15992205 SGTC_2687 chenodiol 100 µM -1.33697513810008 0.0787381255595173 no 3065 0.0906153761741381 980 5702181 A cholesterol synthesis inhibitor. SGTC_1341 1486-1360 280 µM -1.34348878393298 0.0777352659868987 no 3066 0.0895568777160102 1010 3976547 SGTC_2011 4012611 177 µM -1.34406935969316 0.0776463516514525 no 3067 0.0894629795661893 1007 2049887 SGTC_3323 9138564 53.9225 µM -1.34554812213351 0.077420230131064 no 3068 0.0892241459617685 996 43912313 YNL103W MET4 SGTC_2086 5274770 176.623 µM -1.3456988651397 0.0773972077340205 no 3069 0.0891998262643499 993 689278 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.35125729268018 0.0765519167143272 no 3070 0.0883065137439772 1002 16486 A toxic proline analog. SGTC_1006 4099-6547 255 µM -1.35533164909072 0.0759367874970289 no 3071 0.0876559578905704 1014 3146833 SGTC_1436 4092-1007 8.32 µM -1.36461385587979 0.0745494616269634 no 3072 0.0861872237633245 984 2881121 SGTC_857 0438-0306 1.35 µM -1.36800398337738 0.0740476223066591 no 3073 0.0856554146265381 984 4686136 SGTC_1242 0402-0103 60.1 µM -1.36870699609314 0.0739438794265397 no 3074 0.0855454412735237 985 432868 SGTC_1624 st003710 6.25 µM -1.36989827161835 0.0737683376950022 no 3075 0.0853593296632517 1004 24207033 SGTC_2691 st077356 60.2 µM -1.37063071788683 0.0736605654962084 no 3076 0.085245051091646 1011 2839272 SGTC_1905 st060207 84.5 µM -1.37255181718817 0.0733784667020697 no 3077 0.0849458597959718 995 1948547 SGTC_914 3820-6779 408 µM -1.37491008916584 0.0730333031038521 no 3078 0.0845796604949591 992 2893481 SGTC_1883 5-benzylidenerhodanine 20 µM -1.37569857698571 0.072918175323406 no 3079 0.0844574863499978 981 1273210 SGTC_1012 4112-3522 18 µM -1.37801482314675 0.0725807816641964 no 3080 0.0840993557941834 994 3112398 SGTC_1976 st070609 63.5 µM -1.37828661971522 0.0725412692067291 no 3081 0.0840574063308216 1002 682556 SGTC_2900 5328528 85.29 µM -1.38001622061485 0.072290214208959 no 3082 0.0837908253070962 1005 795359 SGTC_2551 apiole 73.87 µM -1.38291018203554 0.0718716397620547 no 3083 0.0833462039345381 997 10659 A possible DNA adduct former. SGTC_1120 ficusin 1.78878 µM -1.38673864007793 0.0713207612817414 no 3084 0.0827607367680392 1006 6199 A DNA cross-linker. SGTC_1491 4138-0063 26.5 µM -1.3870334169618 0.0712784804656154 no 3085 0.0827157866320438 1015 23883227 SGTC_1561 5-methoxyflavone 52.9 µM -1.38860589859533 0.0710532592972808 no 3086 0.082476311358469 980 94525 SGTC_145 3737-0113 38.366 µM -1.38870555744183 0.0710390039385003 no 3087 0.0824611517899176 993 6849351 SGTC_3115 9123671 49.47 µM -1.39646720268318 0.0699354990810982 no 3088 0.081286925165469 1041 3286988 SGTC_2713 st079149 53.4 µM -1.39886327818881 0.0695975173091324 no 3089 0.0809269931726889 1006 3103253 SGTC_1244 0416-0015 52.5 µM -1.40021178927018 0.0694078550386821 no 3090 0.0807249532640562 1013 96201 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.40480383758957 0.0687649881936323 no 3091 0.0800398088129631 1028 61125 An anti-inflammatory. SGTC_600 1495-0418 41.6 µM -1.40481884886631 0.068762894234617 no 3092 0.0800375763270747 1011 5377768 SGTC_2964 9083345 53.42 µM -1.4053616546353 0.0686872099823972 no 3093 0.0799568815601539 979 17741579 SGTC_214 4373-3496 70 µM -1.41057282980023 0.0679638730237581 no 3094 0.0791853038679059 1017 3779166 SGTC_2707 st078556 66.6 µM -1.41357677130739 0.0675495916454839 no 3095 0.0787431027659648 983 17250899 SGTC_2280 7785178 200 µM -1.41633826253821 0.067170471173564 no 3096 0.0783382451208876 996 2954328 SGTC_32 0928-0142 34.1 µM -1.41913433758588 0.0667882811847711 no 3097 0.0779299273866901 1004 2244242 SGTC_832 4083-0019 164 µM -1.41932946580516 0.0667616724303964 no 3098 0.0779014927287746 1025 1990758 SGTC_140 0062-0056 502.533 µM -1.42084861437522 0.0665547934451822 no 3099 0.0776803871257152 1014 3758964 SGTC_3030 9087619 49.47 µM -1.42171773091439 0.0664366597502875 no 3100 0.0775541053413317 992 25236973 SGTC_2552 juarezic acid 87.02 µM -1.42831148361736 0.0655456924611702 no 3101 0.0766011119795432 1011 1549512 SGTC_2138 5575593 77.673 µM -1.43009499765701 0.0653062979189129 no 3102 0.0763448778666175 1008 762213 SGTC_2431 5490079 200 µM -1.43059434654338 0.0652393938374494 no 3103 0.0762732543431762 1034 5722345 SGTC_2484 5809818 12.04 µM -1.4334716277027 0.0648549236258938 no 3104 0.0758615507417335 1001 2870548 SGTC_3173 9105693 49.47 µM -1.43501753724745 0.0646490826724921 no 3105 0.0756410501167909 1009 17096658 SGTC_2770 toltrazuril 17.5 µM -1.43526185172798 0.0646165981930648 no 3106 0.0756062470764824 987 68591 Kills coccidiodes. SGTC_1221 2958-7315 257 µM -1.43693129333327 0.0643949655168412 no 3107 0.0753687585319524 1020 4562705 SGTC_1628 st004252 77.7 µM -1.44224413956921 0.0636935693951836 no 3108 0.0746167562816953 1005 692968 SGTC_300 r073-0011 5.04 µM -1.44383271893713 0.0634850052864447 no 3109 0.0743930179866854 1021 2735780 SGTC_1683 st010134 710 nM -1.44687763526345 0.0630867253263191 no 3110 0.0739655989877486 1026 3818134 SGTC_1512 0259-0544 12.2 µM -1.45054697974437 0.0626093577934424 no 3111 0.0734530241538116 996 18476 SGTC_413 propylparaben 100 µM -1.45105321750736 0.0625437198275815 no 3112 0.0733825209987291 1011 7175 A pharmaceutical preservative. SGTC_2340 7987427 183.45 µM -1.45357597088082 0.0622174231736125 no 3113 0.073031951450258 1011 2239331 SGTC_1557 sumaresinolic acid 42.3 µM -1.45483699351233 0.0620548191674038 no 3114 0.0728571970471692 1013 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3344 9148862 3.898 µM -1.45829474128309 0.0616106568415873 no 3115 0.0723796595498323 1037 4905352 SGTC_544 k015-0020 52.4 µM -1.46303473187966 0.0610058237552917 no 3116 0.0717289377406394 1018 3008304 SGTC_1799 st045822 46.1415 µM -1.46944166534578 0.060195674104157 no 3117 0.0708565166207801 978 3674992 SGTC_1741 st038134 10.228 µM -1.47328956773664 0.0597131742594905 no 3118 0.0703364862360927 1024 1272587 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.4745996214492 0.0595495959767873 no 3119 0.0701601083745942 1035 6708784 An antioxidant flavonoid SGTC_2526 patulin 37.61 µM -1.47702476856569 0.0592477099362791 no 3120 0.0698344990062941 1022 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1461 k072-0203 53.8 µM -1.47977533289438 0.0589067693438155 no 3121 0.0694666068411979 1003 5418714 SGTC_1425 4048-4433 7.33 µM -1.48104651998795 0.058749722961331 no 3122 0.0692970887330773 1050 23734946 SGTC_1415 3966-0071 78.1 µM -1.48180090632839 0.0586566792300132 no 3123 0.069196638942059 1014 2893185 SGTC_1669 st015249 58.4 µM -1.48483940164668 0.0582830911633364 no 3124 0.0687931858212068 1042 722793 SGTC_2243 6634756 200 µM -1.48881655747229 0.0577969205673727 no 3125 0.0682678405160765 1011 885676 SGTC_26 0302-0163 425.158 µM -1.48994391660465 0.0576596928777097 no 3126 0.068119491470727 1048 3100915 SGTC_2966 9084041 48.03 µM -1.49176516684498 0.0574385428244881 no 3127 0.0678803592812804 1017 17741380 SGTC_3156 9099931 49.47 µM -1.49354768877567 0.0572227421534628 no 3128 0.0676469404312916 1027 18111053 SGTC_1076 itraconazole 331 nM -1.49425118312361 0.0571377495608875 no 3129 0.0675549896385783 1023 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_586 0957-0265 8.15 µM -1.50198178956639 0.0562103094788442 no 3130 0.0665509059482751 988 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2383 9036125 200 µM -1.50775492520986 0.0555254804262248 no 3131 0.0658086311761681 1031 79580 SGTC_1921 5740136 50 µM -1.51032881575047 0.0552222874154445 no 3132 0.0654797712189624 1000 1774243 SGTC_1294 1000-1494 117 µM -1.51124944099814 0.055114159853433 no 3133 0.0653624550401289 1030 712797 YDL207W GLE1 SGTC_1750 st081859 2.357 µM -1.51758825670469 0.0543741990952305 no 3134 0.0645591145550813 1002 5291695 SGTC_364 0083-0097 67.7 µM -1.52207601225047 0.0538550896548836 no 3135 0.0639950178583986 1044 5207356 SGTC_153 4077-0274 519.67 µM -1.52659611713753 0.0533362128780885 no 3136 0.0634307365774976 1004 3121976 SGTC_1150 3909-7983 10.9 µM -1.53245286384556 0.0526698008629883 no 3137 0.0627053604210498 1027 23965914 SGTC_1422 4031-0024 15.5 µM -1.53524508971341 0.0523544209224652 no 3138 0.0623618182326699 1038 782427 SGTC_2529 gangaleoidin 93.61 µM -1.53581280812911 0.0522904813218848 no 3139 0.0622921487448611 1044 4565183 SGTC_1996 st072960 66.8 µM -1.53826287666607 0.0520152519505294 no 3140 0.061992176359833 1023 1719405 SGTC_2679 rapamycin 1 nM -1.53873826679511 0.0519619823827971 no 3141 0.0619341031027748 967 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2057 5236571 38.335 µM -1.54158728047781 0.0516436455180595 no 3142 0.0615869592055785 1010 54684039 YBR257W POP4 SGTC_1933 st074711 15.9 µM -1.55023005566166 0.05068741638262 no 3143 0.0605431541741076 1029 17250958 SGTC_2655 perillic acid 100 µM -1.55257732223871 0.0504301664767331 no 3144 0.0602620734624578 1048 5702197 An apoptosis inducer. SGTC_1158 4092-0494 91.8 µM -1.55548485893988 0.0501129570573147 no 3145 0.0599153189206924 1033 1148199 SGTC_1011 4112-3381 17.4 µM -1.55554608635646 0.0501062943471976 no 3146 0.0599080337392427 1017 2877139 SGTC_579 4491-1009 110 µM -1.55942990415133 0.0496851022242354 no 3147 0.0594473315371568 1041 1271041 SGTC_2108 5365811 200 µM -1.56135345019876 0.0494775461358159 no 3148 0.0592201893364451 1010 780283 SGTC_1303 1160-0052 261 µM -1.56197967531236 0.0494101241928759 no 3149 0.0591463884918041 1015 3562476 SGTC_1462 k081-0014 26.5 µM -1.56525552310456 0.0490586275801008 no 3150 0.0587615036809273 939 3270634 SGTC_2517 totarol 10 µM -1.56669640179291 0.0489046559484295 no 3151 0.058592836126896 1018 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1460 k062-0059 9.15 µM -1.56860588988198 0.048701204124027 no 3152 0.0583698995996799 1017 1373085 SGTC_1833 st055984 71 µM -1.57026788002487 0.0485246738829197 no 3153 0.0581764017089494 1037 676288 SGTC_3214 9129694 49.47 µM -1.57482803916086 0.0480429381686317 no 3154 0.0576480712270774 1044 17158655 SGTC_1902 st060212 70.5 µM -1.57553388347149 0.0479687159424653 no 3155 0.0575666318701012 1007 688944 SGTC_921 1561-0023 372 µM -1.58224592559236 0.0472674963204448 no 3156 0.056796719943374 1019 24050882 SGTC_323 4013-0906 34.3 µM -1.58292988284096 0.0471965056585617 no 3157 0.056718723387328 1016 2910086 SGTC_768 0384-0033 77.3 µM -1.58807834343619 0.046664865499929 no 3158 0.0561343123725205 1007 3965305 YMR134W ERG29 SGTC_1182 1222-0449 220 µM -1.59028946540701 0.046438020619106 no 3159 0.0558847860573355 1030 658318 SGTC_2317 5986382 200 µM -1.59050376883181 0.0464160817955855 no 3160 0.0558606483882335 1048 877883 SGTC_2957 9076800 11.52 µM -1.59168951573087 0.0462948440007228 no 3161 0.0557272426105437 1038 16459615 SGTC_2173 5763948 167 µM -1.59347002077332 0.0461132722988531 no 3162 0.0555273942572593 1037 2867177 SGTC_744 1594-0068 283 µM -1.59383658206524 0.0460759623380186 no 3163 0.0554863208126551 1044 668392 SGTC_441 propafenone 146 µM -1.59472507913566 0.0459856284421084 no 3164 0.0553868636341778 1027 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2386 9075165 157.42 µM -1.59967974787118 0.045484491012914 no 3165 0.0548348234349009 1034 16452277 SGTC_2373 9071805 200 µM -1.60694123304632 0.0447579764567492 no 3166 0.0540336300802247 1042 10149009 SGTC_892 0929-0076 29 µM -1.60876729361457 0.0445767564868662 no 3167 0.0538336175028399 1022 5751038 SGTC_2166 5933061 31.504 µM -1.61017834786147 0.0444371273441267 no 3168 0.0536794634238409 1044 2877375 SGTC_1335 1486-0900 202 µM -1.61761203426307 0.0437073443913311 no 3169 0.0528731169783734 1025 X1335 SGTC_758 0868-0029 16 µM -1.62109750184176 0.0433685134996507 no 3170 0.0524983648416497 1014 762687 SGTC_181 1447-1644 8.07 µM -1.62629103291806 0.0428675750991142 no 3171 0.0519438792205051 1044 534600 SGTC_2133 5320837 200 µM -1.62737042856818 0.0427640519448504 no 3172 0.0518292240606291 1048 2841355 SGTC_2432 5630864 12.22 µM -1.62755817112044 0.0427460664972732 no 3173 0.0518093022913579 1033 5714970 SGTC_3285 9112818 20.8695 µM -1.6279486209395 0.0427086815867479 no 3174 0.0517678903045712 1031 17017947 YPR165W RHO1 SGTC_168 3970-0862 530.542 µM -1.63026697106298 0.0424872475504905 no 3175 0.0515225425060451 1016 3135186 SGTC_638 3970-0837 4.09 µM -1.63097099007488 0.0424201882324073 no 3176 0.0514482204519622 1033 4118451 YLR208W SEC13 SGTC_1435 4092-0789 56.7 µM -1.63446269837396 0.042088859744057 no 3177 0.0510808662370933 1030 2248285 SGTC_486 niguldipine 82 µM -1.63478450891654 0.04205842882333 no 3178 0.0510471146545461 1035 1236 A calcium channel blocker. SGTC_1246 0422-0085 105 µM -1.63521432615973 0.042017812395521 no 3179 0.0510020629853921 1018 264295 SGTC_640 3381-0960 37.1 µM -1.65091006227645 0.0405562324239092 no 3180 0.0493784704366388 1048 1745025 SGTC_1175 0741-0056 27.6 µM -1.65242232627778 0.040417618001134 no 3181 0.0492242436486583 1044 765927 SGTC_3178 9107506 49.47 µM -1.65304441566693 0.0403607089446924 no 3182 0.0491609122337681 1041 8897194 SGTC_2 0422-0095 29 µM -1.65609156421095 0.0400828935138529 no 3183 0.0488516387175655 1012 6790840 SGTC_2018 5133068 143 µM -1.65722638051517 0.0399798276392389 no 3184 0.0487368574661488 1032 785362 SGTC_2788 5282734 71.43 µM -1.6575594972719 0.0399496143519506 no 3185 0.0487032052522025 1030 743706 SGTC_1173 0443-0020 122 µM -1.65780483355439 0.0399273745155299 no 3186 0.0486784327008131 1050 5331295 SGTC_537 1334-0398 209 µM -1.65964356472473 0.0397610129073403 no 3187 0.0484930894046324 1027 5846986 SGTC_2652 actinonin 100 µM -1.66319928595881 0.0394409030805236 no 3188 0.0481362752688021 1055 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_481 bay k-8644 50 µM -1.6638059597279 0.0393864961924661 no 3189 0.0480756063085278 1039 2303 A calcium channel antagonist. SGTC_1128 3448-9350 235 µM -1.66514977276994 0.0392661996038802 no 3190 0.0479414393850676 1033 619386 SGTC_2163 5671233 125 µM -1.6667479214442 0.0391235246063004 no 3191 0.0477822698273348 1017 701023 SGTC_2190 6049624 200 µM -1.67576212209642 0.0383266639836192 no 3192 0.0468923980991269 1032 2265554 SGTC_534 k292-0788 63.4 µM -1.67576471424896 0.0383264367534361 no 3193 0.0468921441297094 1049 4146317 SGTC_2372 9071633 200 µM -1.69087230453231 0.0370206317405327 no 3194 0.0454305969498386 1053 21321366 SGTC_347 4534-1311 26.2 µM -1.69237049342573 0.0368931438387469 no 3195 0.045287677323973 1041 2862016 SGTC_395 anisomycin 6.25 µM -1.69402879307287 0.0367524501448283 no 3196 0.0451299059141452 1051 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_209 4077-0173 175.592 µM -1.69696641278715 0.0365042935161045 no 3197 0.0448515053397869 1052 15993494 SGTC_2036 5160441 105 µM -1.69971010904669 0.0362737585361558 no 3198 0.0445927334540063 1023 134534 YIL048W NEO1 SGTC_1194 1488-0194 225 µM -1.70076078318292 0.0361857933918151 no 3199 0.0444939580586098 1050 1391452 SGTC_1197 1601-0112 267 µM -1.70080147856277 0.0361823897863916 no 3200 0.0444901357759152 1049 7350313 SGTC_1413 3910-0535 34.4 µM -1.7011529240778 0.0361530071371183 no 3201 0.0444571375285787 1045 2876951 SGTC_754 3474-0146 171 µM -1.70323682225358 0.0359791836937293 no 3202 0.0442618791580354 1029 24762078 SGTC_1278 0874-0585 172 µM -1.70487928378306 0.035842664558552 no 3203 0.0441084703839205 1058 766306 SGTC_571 k831-0106 44.2 µM -1.70688597147842 0.035676447778788 no 3204 0.0439216243842048 1029 4783639 SGTC_1922 5578187 25 µM -1.70911709389424 0.0354923829990412 no 3205 0.04371463090115 1010 1350412 SGTC_647 0140-0236 81 µM -1.70962778855444 0.0354503610275811 no 3206 0.0436673618253071 1062 990837 SGTC_712 r015-0009 80.6 µM -1.71435415262353 0.0350633898516432 no 3207 0.0432318516274389 1054 6813872 YLR060W FRS1 SGTC_1029 k015-0030 64.7 µM -1.71481700266428 0.0350256810620342 no 3208 0.0431893916150463 1024 2208316 SGTC_2390 9097792 176.6 µM -1.72755340665768 0.0340010253329669 no 3209 0.0420341611905197 1042 4497149 SGTC_2446 5162541 200 µM -1.73006146726167 0.0338021832540766 no 3210 0.0418096468737977 1059 1549321 SGTC_1756 st041558 35.5 µM -1.73320866645512 0.0335540239706572 no 3211 0.0415292936054563 1046 3955792 SGTC_1487 3970-0795 2.82 µM -1.74506507388793 0.0326325675127289 no 3212 0.0404867711319779 1037 3765103 SGTC_2832 7992762 51.95 µM -1.7453584727521 0.032610032422606 no 3213 0.0404612447526301 1019 2985177 SGTC_65 0798-0905 34.986 µM -1.74594534814128 0.0325649947890912 no 3214 0.0404102244464915 1061 3602145 SGTC_158 k038-0087 26.446 µM -1.74657967769669 0.032516373164179 no 3215 0.0403551374471327 1031 X158 SGTC_859 0439-0102 54.6 µM -1.75529080746277 0.0318546985221866 no 3216 0.0396047890283522 1039 610143 SGTC_497 capsazepine 133 µM -1.75970766909395 0.0315234780953451 no 3217 0.039228692414128 1048 2733484 A calcium channel blocker. SGTC_148 3253-0744 288.01 µM -1.77124137693084 0.0306719680923573 no 3218 0.0382602856617931 1027 6893655 SGTC_1568 digitonin 820 nM -1.78109955326179 0.0299593387141557 no 3219 0.0374480943599786 1033 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2276 7947513 42.08 µM -1.7814873054193 0.0299315918776435 no 3220 0.0374164384548883 1056 2105100 SGTC_3286 9117135 37.221 µM -1.78490470433066 0.0296879695363484 no 3221 0.037138387741294 1051 3438150 SGTC_1777 st045864 34.765 µM -1.78666242903233 0.0295633056186005 no 3222 0.0369960324842286 1070 4691462 SGTC_2821 7996764 71.43 µM -1.78829757001094 0.0294477261681783 no 3223 0.036864005854573 1019 2987135 SGTC_1285 0929-0069 65.5 µM -1.80000796797117 0.0286308988582639 no 3224 0.0359296900448521 1058 1206237 SGTC_1903 st060211 78.3 µM -1.80361794568425 0.0283829272260077 no 3225 0.0356456104113239 1039 688960 SGTC_371 0195-0006 7.36 µM -1.81567986640052 0.0275673137259696 no 3226 0.0347097471324445 1016 3928593 SGTC_741 4582-0002 126 µM -1.81748217663809 0.0274471378751358 no 3227 0.034571657489547 1047 2912688 SGTC_2586 curcumin 80 µM -1.8188175300163 0.0273583801344969 no 3228 0.0344696365142703 1067 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1660 st012960 28.1 µM -1.82465511163906 0.0269731758447043 no 3229 0.0340265455738156 1048 24207266 SGTC_599 1935-0052 86.5 µM -1.82525582654411 0.0269337946573204 no 3230 0.0339812164051984 1060 9557311 SGTC_854 0422-0053 192 µM -1.83593084159817 0.0262419375426234 no 3231 0.0331839428102208 1056 3596728 SGTC_993 3909-8757 62.7 µM -1.8400225444228 0.0259807193904946 no 3232 0.0328824637792685 1050 4288324 YLR208W SEC13 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.84012168184247 0.0259744174521041 no 3233 0.032875187382851 1060 688798 SGTC_1146 3579-1023 7 µM -1.84303660555813 0.025789693209791 no 3234 0.0326618330387015 1063 X1146 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.85291198548038 0.0251720243973744 no 3235 0.0319474874637809 1054 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.85445797884794 0.0250764596638917 no 3236 0.0318368333059815 1066 94937 An inhibitor of serotonin biosynthesis. SGTC_1643 st009866 20.2 µM -1.86408037892959 0.0244884695114024 no 3237 0.0311552087466653 1042 3156273 YOR207C RET1 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.86506698313103 0.0244288411682249 no 3238 0.0310860079061627 1058 688761 SGTC_678 1218-2179 85.9 µM -1.8659726984586 0.0243742089344883 no 3239 0.0310225926502484 1071 6820081 YOR116C RPO31 SGTC_2441 5730946 39.09 µM -1.87029253240646 0.0241150484029783 no 3240 0.0307216029905831 1049 1774275 SGTC_130 0136-0219 337.655 µM -1.87079752579278 0.0240849039263258 no 3241 0.030686575350265 1049 234244 SGTC_369 0957-0393 4.5 µM -1.87538652844653 0.02381242161543 no 3242 0.030369783545909 1058 6997992 SGTC_3009 9080819 71.4286 µM -1.87539777500296 0.0238117570226271 no 3243 0.0303690105058492 1062 17027216 SGTC_1309 pyrazolanthrone 13.4 µM -1.88215205649551 0.0234154331130733 no 3244 0.0299076865310405 1052 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_149 3970-0822 46.1 µM -1.88238043555769 0.0234021300135283 no 3245 0.0298921901709463 1038 3114250 YBL034C STU1 SGTC_557 1315-0110 16.2 µM -1.88431097224424 0.0232899299878093 no 3246 0.0297614620621097 1054 6833801 SGTC_1633 st005664 67.9 µM -1.89142103054853 0.0228806004439487 no 3247 0.0292840817032978 1070 2063822 SGTC_295 k015-0027 31 µM -1.8919184776549 0.0228521904476818 no 3248 0.0292509217309565 1067 3887424 SGTC_755 1995-0008 37.3 µM -1.90239301414141 0.0222608399552 no 3249 0.028559896814864 1059 689533 SGTC_1431 4049-0260 9.09 µM -1.9099958154128 0.0218397480094241 no 3250 0.028066876054799 1066 3854841 SGTC_170 4197-0004 226 µM -1.91037493753544 0.0218189270903004 no 3251 0.028042477698313 1054 218692 SGTC_2253 7938677 135.83 µM -1.91103425687072 0.0217827580153035 no 3252 0.0280000893517775 1073 2301972 SGTC_1603 st002045 67.8 µM -1.91118913177001 0.0217742692056837 no 3253 0.0279901400218488 1065 5887985 SGTC_2366 9070441 60.58 µM -1.91277725202536 0.021687384264274 no 3254 0.0278882872609996 1058 6837235 SGTC_1607 st000305 50.6 µM -1.92040356188817 0.0212742241135699 no 3255 0.0274034719951792 1060 5457690 SGTC_2271 7849410 118.62 µM -1.92352439864612 0.0211070804968512 no 3256 0.0272071126791721 1062 972430 SGTC_2279 7948423 32.93 µM -1.92928654172111 0.0208013943680179 no 3257 0.026847649788982 1051 1247112 SGTC_3012 9080433 71.4286 µM -1.93011171362507 0.0207579266978499 no 3258 0.0267964986931798 1050 17688859 SGTC_3324 9138759 60.749 µM -1.93716703152503 0.0203894035016506 no 3259 0.0263624644382176 1056 45595710 SGTC_2761 levamisole 97.89 µM -1.94161423507035 0.0201599719339773 no 3260 0.0260919091449287 1059 26879 An alkaline phosphatase inhibitor. SGTC_637 1181-0519 7.26 µM -1.96093700637245 0.0191883663454577 no 3261 0.0249431858720359 1043 6252091 YGR060W ERG25 SGTC_162 k030-0015 37.8 µM -1.96568726561799 0.0189556994082196 no 3262 0.0246673733539582 1066 1809920 YMR134W ERG29 SGTC_1450 4112-4260 37.6 µM -1.97287448050008 0.0186082347163091 no 3263 0.0242549323814534 1053 1633175 SGTC_304 1310-0298 97 µM -1.97721842328909 0.0184008678468252 no 3264 0.0240084730008406 1070 1550234 SGTC_1893 st059353 36.1 µM -1.98019854999306 0.0182597466116757 no 3265 0.0238406113715685 1066 3112488 SGTC_720 r052-1644 49.9 µM -1.98392372926142 0.0180846418468915 no 3266 0.0236321715789976 1067 1422863 YOR257W CDC31 SGTC_339 3091-4833 71.4 µM -1.98807202368718 0.0178913347757112 no 3267 0.0234018624738345 1039 3240077 SGTC_2556 citropten 84.59 µM -1.99935228570685 0.0173745732588329 no 3268 0.0227851253272628 1051 2775 A potential DNA crosslinker. SGTC_2549 cedrol 20.94 µM -2.00089689485398 0.0173048149936894 no 3269 0.0227017511401122 1060 6708665 A sedative which affects the nervous system. SGTC_2034 5197015 53.07 µM -2.00536049298058 0.0171045712910149 no 3270 0.0224622610209096 1066 780676 SGTC_1743 st037606 46.3785 µM -2.00691142584611 0.0170354592634362 no 3271 0.0223795475147581 1047 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_103 0844-0104 51.839 µM -2.0275620153693 0.0161377480519762 no 3272 0.0213024845334523 1036 5375804 SGTC_447 ml7 120 µM -2.03463506683678 0.0158397375766958 no 3273 0.0209438031032869 1085 4216 Selective myosin light chain kinase inhibitor. SGTC_2425 5628681 7.85 µM -2.03586703007301 0.0157883165203919 no 3274 0.0208818546554099 1064 5714958 SGTC_860 0443-0016 25.1 µM -2.03730992787027 0.0157282733427893 no 3275 0.020809496790528 1069 5337942 SGTC_2572 astragaloside iv 100 µM -2.03795174706878 0.0157016283836976 no 3276 0.0207773793741995 1054 45006101 An anti-inflammatory agent. SGTC_582 0987-0078 156 µM -2.06009812190075 0.0148056533113754 no 3277 0.0196945806982261 1076 1625765 SGTC_2414 st077232 92.9 µM -2.06968855998638 0.0144315108124614 no 3278 0.0192407593709706 1057 729801 SGTC_2683 piperine 63.03 µM -2.07863300993769 0.0140899342881059 no 3279 0.0188255472622098 1077 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2922 7999257 32.47 µM -2.08019849580931 0.0140308725029682 no 3280 0.0187536650825199 1064 2988377 SGTC_1292 0kpi-0043 232 µM -2.08091771201519 0.0140038099274523 no 3281 0.0187207193235113 1078 3333905 SGTC_2622 2-methoxyxanthone 59.94 µM -2.08754967713218 0.0137563764395022 no 3282 0.01841923772375 1073 71034 A hepatoprotective. SGTC_3067 9117431 49.47 µM -2.0892275929253 0.0136943757511658 no 3283 0.0183436203537622 1075 17150885 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -2.09548381170263 0.0134653227766124 no 3284 0.0180640030109659 1062 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1708 st033234 31.827 µM -2.10805237763495 0.0130151429847296 no 3285 0.0175132295368893 1074 674664 SGTC_3200 9114385 49.47 µM -2.12128587612139 0.0125552671072563 no 3286 0.0169488761093078 1057 17018030 YLR208W SEC13 SGTC_591 4299-0174 154 µM -2.13085493049958 0.0122315595572493 no 3287 0.0165505476714411 1076 5509088 SGTC_3207 9114163 49.47 µM -2.14740340468473 0.0116888005905547 no 3288 0.0158805899200219 1065 849233 SGTC_2634 4'-methoxyflavone 100 µM -2.17294211771629 0.0108922125276311 no 3289 0.014892336999988 1070 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_31 0508-1974 57.237 µM -2.17432054166971 0.0108505947700509 no 3290 0.0148405353891663 1068 6810525 SGTC_3002 9075603 71.4286 µM -2.17476437475106 0.0108372239279647 no 3291 0.0148238890121694 1067 20105405 SGTC_1617 st002906 78 µM -2.17842210766899 0.0107275767256568 no 3292 0.0146873127310421 1076 5150859 SGTC_392 N-ethylmaleimide 8.33 µM -2.19376188964055 0.010278192602344 no 3293 0.0141262659639656 1067 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2267 7931562 200 µM -2.20281278903962 0.0100208176193127 no 3294 0.0138039731966541 1073 934880 SGTC_736 0958-0254 92.6 µM -2.20404371449938 0.0099862527180369 no 3295 0.0137606349624856 1084 6812352 SGTC_380 3970-0968 6 µM -2.20417783044683 0.00998249298082808 no 3296 0.013755920126988 1077 2891601 SGTC_2419 paclitaxel 166.5 µM -2.22486615836797 0.00941712270227754 no 3297 0.0130451122284911 1063 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -2.23872940250352 0.00905412432480353 no 3298 0.0125867641057794 1075 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1787 fluconazole 80 µM -2.25211176935491 0.0087154009230059 no 3299 0.0121576048670394 1053 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1546 5-methoxyflavanone 78.7 µM -2.25928726742285 0.00853839753410315 no 3300 0.011932760708402 1090 147795 SGTC_2453 5731132 22.18 µM -2.28322123525719 0.00797060118124974 no 3301 0.0112086699368631 1078 1362040 SGTC_172 1112-0046 2.638 µM -2.29576604993043 0.00768647019959939 no 3302 0.0108446307942441 1081 2802135 YIL048W NEO1 SGTC_1992 st073643 23.3 µM -2.29717280194679 0.00765517101269893 no 3303 0.0108044570080293 1086 3161292 SGTC_1060 3448-7350 82 µM -2.31654133319142 0.00723550454734545 no 3304 0.010264365180194 1075 570178 SGTC_3054 9094397 49.47 µM -2.33056655804686 0.00694440992473013 no 3305 0.00988811329982067 1081 2598354 SGTC_3226 9131256 49.47 µM -2.33919980662923 0.00677041177839909 no 3306 0.0096625475485743 1078 17178073 SGTC_578 3460-0051 92 µM -2.34760329192025 0.00660475533882573 no 3307 0.0094473167171829 1080 2876744 SGTC_222 nsc-310342 10.666 µM -2.35345750181692 0.00649148013971819 no 3308 0.00929986693220544 1086 432556 SGTC_2877 9040724 71.43 µM -2.37522566074491 0.00608521130195242 no 3309 0.00876911214818351 1082 6463895 SGTC_71 0417-1750 47.813 µM -2.40139435717006 0.00562675600429229 no 3310 0.00816636215076182 1054 6811472 SGTC_719 2810-4230 27.3 µM -2.4116684120429 0.00545531970676718 no 3311 0.00793985807498104 1090 721079 SGTC_2106 5357045 167.29 µM -2.42500971985664 0.00523963756284908 no 3312 0.00765398844842401 1087 668842 SGTC_568 1193-0097 7.48 µM -2.42629010098266 0.00521934268771027 no 3313 0.00762703567711088 1037 3646150 SGTC_2952 9073731 13.78 µM -2.46798587184105 0.00459552156244008 no 3314 0.00679378411714783 1083 16457353 SGTC_1145 3546-0597 10.2 µM -2.47195145659669 0.00453980562945089 no 3315 0.00671888809273888 1091 875334 SGTC_1184 1269-1718 139 µM -2.4743909765159 0.00450583106357798 no 3316 0.00667317744116058 1084 5403821 SGTC_1859 st055998 20 µM -2.47524986951527 0.00449392363084225 no 3317 0.00665714942964444 1076 676301 SGTC_1385 3091-4834 14.1 µM -2.51712065586551 0.00394645170666601 no 3318 0.00591591516661027 1085 4072814 SGTC_2003 4023581 200 µM -2.51828570660716 0.0039321118958404 no 3319 0.00589638096155254 1070 16641307 SGTC_1452 4194-0072 190 µM -2.52942924586276 0.00379729412245645 no 3320 0.00571241032876455 1077 1343545 SGTC_1811 st050069 61.5 µM -2.53533000388423 0.00372759624429662 no 3321 0.00561707197930916 1090 3877702 SGTC_2388 9080168 200 µM -2.56664911408435 0.00337651737814685 no 3322 0.00513432318954306 1083 15943073 SGTC_3053 9095903 49.47 µM -2.57596911003455 0.0032779403940797 no 3323 0.00499797879810774 1093 17174018 SGTC_2774 tamoxifen 10.92 µM -2.58236462728682 0.00321180090994105 no 3324 0.00490629251112544 1081 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_248 streptozotocin 5.23457 mM -2.59956341424824 0.00303985416869446 no 3325 0.00466712152135187 1087 5300 DNA alkylating agent. SGTC_1622 st003707 19.4 µM -2.60464770490226 0.0029906359549217 no 3326 0.00459843851475171 1082 10140899 SGTC_1802 st050112 57.9 µM -2.6364816100293 0.00269845784355294 no 3327 0.00418853703919629 1090 4662563 SGTC_2470 5664817 21.68 µM -2.63660111539396 0.00269741134859364 no 3328 0.0041870619070822 1092 2859561 SGTC_2272 7805186 180 µM -2.64455150636796 0.0026286083406972 no 3329 0.00408996282173173 1081 2956062 YPR165W RHO1 SGTC_782 0083-0095 30.5 µM -2.64560047070431 0.00261964993640023 no 3330 0.00407730333517935 1089 3591729 An indicator and reagent. SGTC_752 1896-0090 130 µM -2.67071754569078 0.00241321678080189 no 3331 0.00378446537510268 1092 772567 SGTC_3007 9078383 71.4286 µM -2.69756519395546 0.00220893525016172 no 3332 0.0034924303165846 1090 6496995 SGTC_550 4123-0385 25.7 µM -2.71089303894663 0.00211346189743565 no 3333 0.0033551134203088 1088 5731123 SGTC_2909 7941780 10.49 µM -2.73365230646422 0.00195904360338059 no 3334 0.00313180736558864 1083 1243215 SGTC_1809 st050081 57.6 µM -2.78529548959918 0.00164595973014879 no 3335 0.00267394817004231 1085 5036894 SGTC_237 nikkomycin 200 µM -2.79600255172815 0.00158705138399975 no 3336 0.00258694959619765 1093 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_850 0388-0143 75.9 µM -2.81947188164977 0.00146459328600052 no 3337 0.00240513726048703 1093 67273 SGTC_3158 9100007 49.47 µM -2.84505342126766 0.00134098451679139 no 3338 0.0022201987647904 1089 19297233 SGTC_73 0327-0325 16.231 µM -2.8636703610537 0.00125710525124328 no 3339 0.00209381778885192 1044 53298 SGTC_569 4130-2812 160 µM -2.8649387428701 0.00125156896256819 no 3340 0.00208544958830282 1090 743552 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -2.89404875067598 0.00113048226031764 no 3341 0.00190154555271856 1084 5024745 SGTC_1572 epiandrosterone 68.9 µM -2.9167826841355 0.00104348858876435 no 3342 0.00176831042912993 1084 441302 A steroid. SGTC_3147 9097027 49.47 µM -2.91964861665559 0.00103296885704554 no 3343 0.00175213130445399 1088 25236841 SGTC_714 4296-0578 26.1 µM -3.16656059956216 0.000417913003659596 yes 3344 0.000771266013039824 1094 1589775 SGTC_1981 st071826 47 µM -3.22929716420704 0.00032873308985502 yes 3345 0.000620474376568892 1092 11838600 SGTC_2772 vinpocetine 57.06 µM -3.27667911000787 0.000273483858568104 yes 3346 0.000525178345366801 1089 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1141 3253-0389 52.6 µM -3.2857257283676 0.000263972311357465 yes 3347 0.000508600015428942 1091 5402031 SGTC_749 1000-0129 128 µM -3.30336693620841 0.000246304873823865 yes 3348 0.000477656474872725 1095 708470 SGTC_1653 st012112 65 µM -3.41543790760716 0.000157413820186959 yes 3349 0.00031839772999115 1095 720429 SGTC_2132 5317594 122.667 µM -3.62683828211522 6.52682288482476e-05 yes 3350 0.000143456430288347 1091 794577 SGTC_2624 nerol 100 µM -3.62736976948355 6.51200664653985e-05 yes 3351 0.000143161554410923 1091 637566 A natural product oil. SGTC_1052 3253-3998 198 µM -3.93379169316267 1.67149507551742e-05 yes 3352 4.18081277086658e-05 1091 5450317 SGTC_457 grayanotoxin iii 135 µM -3.93515942842525 1.66100953106502e-05 yes 3353 4.15707433810671e-05 1082 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3049 9092223 49.47 µM -4.07254714591975 8.73884099177543e-06 yes 3354 2.32508917309404e-05 1092 8623917 SGTC_3208 9114115 49.47 µM -4.11389056006842 7.17489565583646e-06 yes 3355 1.94522966845092e-05 1092 650895 SGTC_1056 3448-1962 115 µM -4.75300227632626 2.69905221478968e-07 yes 3356 1.00209045327616e-06 1093 715507