SGTCid condition conc unit AHP1|YLR109W.score AHP1|YLR109W.strain.pval AHP1|YLR109W.strain.significant AHP1|YLR109W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2835 9006588 71.43 µM 5.54011261827472 4.86395946696879e-09 yes 1 1.51138596286753e-08 11 2345538
SGTC_699 0375-0592 111 µM 4.79175905591 3.54762106234267e-07 yes 2 8.26626872276942e-07 10 762578
SGTC_3137 9097352 49.47 µM 4.62333874532001 8.59434458118881e-07 yes 3 1.8880615581445e-06 22 44120435
SGTC_1764 st044502 93.5 µM 4.52609283689385 1.41338902494547e-06 yes 4 3.00420966302765e-06 22 8407
SGTC_3186 9110464 49.47 µM 4.22022364171138 6.33931926501126e-06 yes 5 1.22030040044367e-05 10 17018021
SGTC_3101 9120531 49.47 µM 4.07669008882318 1.23998399411459e-05 yes 6 2.28406563371526e-05 28 24824904
SGTC_247 mechlorethamine 29.705 µM 3.95371399483013 2.16631329253935e-05 yes 7 3.84736903896485e-05 14 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3142 9086498 49.47 µM 3.91050691187215 2.62572766649414e-05 yes 8 4.60513122310987e-05 38 25236367
SGTC_1528 arabinosylhypoxanthine 74.6 µM 3.86102604893182 3.26500031025604e-05 yes 9 5.64559317604114e-05 25 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1708 st033234 31.827 µM 3.85316202622656 3.37926948371392e-05 yes 10 5.83010872804169e-05 19 674664
SGTC_1610 st001799 48.1 µM 3.75916383176648 5.07296499773637e-05 yes 11 8.52410890689093e-05 13 621897
SGTC_2709 st078560 56 µM 3.66656886834603 7.50279240931214e-05 yes 12 0.000122913368050781 18 17250903
SGTC_3106 9121286 49.47 µM 3.58981900456169 0.000103089271440029 yes 13 0.000165453823432401 22 15943471
SGTC_2044 5102272 200 µM 3.50887803327023 0.00014318915210519 yes 14 0.000225000607995082 21 592666
SGTC_1088 bifonazole 369 nM 3.49553877836831 0.000151059641562496 yes 15 0.000236552850694484 27 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_458 nppb 133 µM 3.47829519289741 0.000161834788788306 yes 16 0.000252306943169948 24 4549 A chloride channel blocker.
SGTC_964 1287-0107 19.4 µM 3.42572763716483 0.000199288949959542 yes 17 0.000306577446839046 70 51516812 YPR165W RHO1
SGTC_457 grayanotoxin iii 135 µM 3.42288130434463 0.000201531904111355 yes 18 0.000309805635675543 100 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1149 3909-7961 23.3 µM 3.40023026695752 0.000220240281807454 yes 19 0.000336645637362341 42 735261
SGTC_3202 9113761 49.47 µM 3.3234062292845 0.000296461836071049 yes 20 0.000444626569443022 76 4798415
SGTC_431 k089-0097 107 µM 3.2642640992078 0.000371161078896806 yes 21 0.000548744063736909 73 5499420
SGTC_115 0527-0192 112.043 µM 3.23178815582222 0.000419274489266109 yes 22 0.000615091100537404 120 4233931
SGTC_2581 avocatin a 64 µM 3.22514675625205 0.000429800471346677 yes 23 0.000629540541501881 81 6710728 A skin care supplement.
SGTC_2515 chrysin 20.77 µM 3.21252848878634 0.000450477327512814 yes 24 0.000657860493941448 23 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3039 9090270 49.47 µM 3.19605634123399 0.000478857427061123 yes 25 0.000696599519432821 30 17173750
SGTC_418 lividomycin a 100 µM 3.18058224813997 0.000507018005685528 yes 26 0.000734897050672177 37 72394 An antibiotic.
SGTC_429 1112-0049 25.5 µM 3.16754933534158 0.00053191705516091 yes 27 0.000768648118489933 68 2836170
SGTC_1700 st030840 7.9285 µM 3.09836178478536 0.000684111602786416 yes 28 0.000972968575880494 50 5499307
SGTC_1770 st043884 66.3 µM 3.09683208740159 0.000687890732904302 yes 29 0.00097800317609637 49 670149
SGTC_1272 0839-0021 27 µM 3.09649595456314 0.000688723727963087 yes 30 0.00097911266993731 52 5027250
SGTC_113 0099-0221 2.5 µM 3.08914623014212 0.000707171786012308 yes 31 0.00100366305867967 67 89219
SGTC_3153 9100258 49.47 µM 3.04575437824791 0.000825694339566443 yes 32 0.00116048676927386 72 25236848
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 3.0248276382642 0.000889159239048627 yes 33 0.00124387428563781 47 4213774
SGTC_159 3970-0959 50 µM 3.02227473109375 0.000897201043518407 yes 34 0.00125441368811131 162 6615653
SGTC_1926 methyl fluorone black 53.6 µM 2.97656149985607 0.00105299488452891 no 35 0.00145750305196532 109 72721 Reacts with homocysteine.
SGTC_2295 7971645 200 µM 2.96141993641955 0.00110983371832479 no 36 0.00153112049266401 66 2978226 YKL099C UTP11
SGTC_935 2996-0153 430 µM 2.95037762045353 0.00115304277248812 no 37 0.00158692876226791 66 23738523
SGTC_1135 dihydrocapsaicin 536.708 nM 2.9299954906284 0.00123686848298462 no 38 0.00169483461398191 89 107982 A Capsaicinoid.
SGTC_3193 9111931 49.47 µM 2.92127959242051 0.00127438754691296 no 39 0.00174298416912173 71 17087244
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 2.91482689411406 0.0013028316890054 no 40 0.00177942940706341 104 688788
SGTC_1705 st027868 56.3335 µM 2.90896712643061 0.00132916378303717 no 41 0.00181312494102881 51 292948
SGTC_3291 9121177 71.43 µM 2.89946931475358 0.00137287907258774 no 42 0.0018689746533867 58 17015612
SGTC_2229 7354935 190 µM 2.89909033018955 0.00137465035858879 no 43 0.00187123528724606 30 318112
SGTC_1791 st048313 56.1 µM 2.87019425173001 0.00151601520431002 no 44 0.00205109852122104 49 1204976
SGTC_184 1494-0393 24.714 µM 2.85946356506627 0.00157180249525798 no 45 0.00212179081276974 135 3090647
SGTC_75 0159-0059 199.013 µM 2.79164001505961 0.0019698781308093 no 46 0.00262208316865198 86 5377270
SGTC_2307 7538926 6.34 µM 2.78635089137393 0.00200447753683086 no 47 0.00266525677762303 115 96582
SGTC_2213 7173844 200 µM 2.77855582031637 0.00205647623027842 no 48 0.00273005655026146 64 892728
SGTC_258 haloperidol 50.781 µM 2.77549990347805 0.00207719320760962 no 49 0.00275584578490315 109 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2148 5546263 113.568 µM 2.75905498372998 0.00219196470893926 no 50 0.00289843903032295 76 792097
SGTC_1200 1643-0193 18.4 µM 2.74181147186712 0.00231845598150078 no 51 0.00305507000435781 64 5403974
SGTC_982 1491-0518 27.5 µM 2.71850169155754 0.0024999517379458 no 52 0.00327891602203359 70 3091256
SGTC_65 0798-0905 34.986 µM 2.6990098737243 0.00266147815316783 no 53 0.00347730564684803 195 3602145
SGTC_2236 dapsone 200 µM 2.68270394062538 0.00280377995252763 no 54 0.00365148046020623 61 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1403 3909-7815 62.9 µM 2.67123431847256 0.00290794985119478 no 55 0.00377864358027169 71 6615483
SGTC_859 0439-0102 54.6 µM 2.64277758270495 0.00318162832364278 no 56 0.00411145158738851 94 610143
SGTC_2298 7976326 193.81 µM 2.63585105037481 0.00325165699266334 no 57 0.00419632814553842 58 2235818
SGTC_2053 5265679 138 µM 2.62754230944248 0.00333748715493945 no 58 0.00430020729183658 119 764595
SGTC_2806 7952793 58.44 µM 2.60827503883083 0.00354440705805132 no 59 0.00454999020729055 102 2972490
SGTC_1189 1431-2119 7.28 µM 2.60668197035931 0.00356202078573016 no 60 0.00457121154764291 130 3107275
SGTC_1296 1068-0102 11.9 µM 2.60508768338958 0.00357972661617299 no 61 0.00459253752852078 70 767053
SGTC_2205 7238770 200 µM 2.58559966397791 0.00380263087235272 no 62 0.00486048822699984 57 279867
SGTC_1816 st051957 91.6 µM 2.5700756526451 0.00398901371775408 no 63 0.00508381540856508 79 674121
SGTC_473 2-arachidonoylglycerol 10 µM 2.55167718594422 0.00422047091098002 no 64 0.00536028986871734 98 5282280 An endocannabinoid.
SGTC_1040 k898-0338 155 µM 2.54383923569339 0.00432267043169524 no 65 0.00548207669654608 107 20969351
SGTC_2215 7188065 200 µM 2.53036712391442 0.00450351226643478 no 66 0.00569716170607642 65 940217
SGTC_1683 st010134 710 nM 2.52279872835321 0.00460804312346867 no 67 0.0058212508303311 136 3818134
SGTC_1103 duloxetine 36.1 µM 2.51530055343814 0.00471373404100287 no 68 0.00594654738539372 144 60835 A selective serotonin reuptake inhibitor.
SGTC_2275 7947463 200 µM 2.49823012715972 0.0049624554940529 no 69 0.00624075690699788 99 1225414
SGTC_2226 7298446 200 µM 2.49789416007101 0.00496746580743816 no 70 0.00624667442710114 63 3283010
SGTC_2908 7930301 100 µM 2.49379322835845 0.00502898766091831 no 71 0.00631930723592786 146 2223178
SGTC_2705 st078069 42.8 µM 2.48522901754952 0.00515965993257197 no 72 0.00647340570391184 85 1530061
SGTC_3283 9109332 35.8195 µM 2.48273022728937 0.00519835159393604 no 73 0.00651898927768678 85 17027281
SGTC_244 nsc-207895 1.295 µM 2.48081033275818 0.00522825470834081 no 74 0.00655420511586292 64 42640
SGTC_959 1222-0044 107 µM 2.47296573324774 0.0053520336847845 no 75 0.00669984952290996 109 6083612
SGTC_1399 3562-5772 25 µM 2.46393269611977 0.00549778699004961 no 76 0.00687109566474239 87 23847490
SGTC_973 1325-0077 65.9 µM 2.46188094245296 0.00553138072931299 no 77 0.00691052686977771 94 2835149
SGTC_1004 4084-0029 199 µM 2.45965353460948 0.0055680568234596 no 78 0.00695355992717659 126 716894 YLR208W SEC13
SGTC_937 3122-0005 46.7 µM 2.44229789637575 0.00586130846948168 no 79 0.00729704925216752 141 759535
SGTC_919 tnp00227 403.569 nM 2.44154179410906 0.00587438985838601 no 80 0.00731234770896102 155 1269246 A methoxyflavone. YNL221C POP1
SGTC_3175 9106517 49.47 µM 2.4412852074194 0.00587883496772171 no 81 0.00731754573070041 92 41468073
SGTC_2825 7998094 58.44 µM 2.43232425189527 0.00603595793604916 no 82 0.0075011350837443 131 2987815
SGTC_2933 9026794 32.47 µM 2.42985913014438 0.00607982956283477 no 83 0.007552346156944 145 17586027
SGTC_2916 7875993 68.79 µM 2.42865555709312 0.00610135196607814 no 84 0.00757746117751442 142 1299250
SGTC_205 1486-1330 71.903 µM 2.42645312777399 0.00614091086422691 no 85 0.00762360987232532 76 4118834
SGTC_3011 9081274 71.4286 µM 2.42069494017653 0.00624541209378336 no 86 0.00774543549523061 131 6625322
SGTC_10 0279-0212 42.575 µM 2.41980779592531 0.00626165147185559 no 87 0.00776435627697348 283 39851 YBR002C RER2
SGTC_526 4469-0568 170 µM 2.41419371019266 0.00636528828073275 no 88 0.00788503786018211 142 2901964
SGTC_125 0133-0007 11.75 µM 2.40722256174777 0.00649608767658215 no 89 0.00803718523327107 112 26541
SGTC_1438 4092-1045 4 µM 2.40198327839523 0.00659595139870469 no 90 0.00815322690178292 89 1351342
SGTC_131 0141-0277 33.849 µM 2.39556558095631 0.00672012432691887 no 91 0.00829737264899613 165 1547771
SGTC_1699 st031318 29.054 µM 2.39343015391782 0.00676189732083051 no 92 0.0083458295261362 112 5340658
SGTC_1862 st057513 3.81 µM 2.37584835960152 0.00711464186249165 no 93 0.00875432828110215 99 5393163
SGTC_2476 5806916 10.51 µM 2.37274168268959 0.00717863166145809 no 94 0.00882830377129739 113 2870194
SGTC_1421 4029-0249 71.4 µM 2.37254596492276 0.00718267990445505 no 95 0.00883298245014784 133 2894095
SGTC_422 cantharidin 155 µM 2.34231706321565 0.00783262651908067 no 96 0.0095822132347699 209 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3231 9132313 49.47 µM 2.33479254210679 0.0080022411202321 no 97 0.00977713049738215 110 4905967
SGTC_2151 5563267 85.4165 µM 2.33081688367384 0.00809315599274143 no 98 0.00988150872801019 154 5310824
SGTC_2278 7948257 134.34 µM 2.32294962763718 0.0082757425195614 no 99 0.0100909293191785 127 1247028
SGTC_2566 crystal violet carbinol 226 nM 2.315188932635 0.00845939060893858 no 100 0.0103012973368133 158 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1137 ixabepilone 100 µM 2.31117514170859 0.00855576839196014 no 101 0.0104115914176636 195 154225 A novel microtubule stabilizer.
SGTC_256 clotrimazole 625 nM 2.30658142418368 0.00866725218316001 no 102 0.0105390830464148 176 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_916 4466-0038 42 nM 2.30179644202894 0.00878473036743041 no 103 0.0106733271528626 247 5722064 YGL116W CDC20
SGTC_1661 st013063 9.66 µM 2.28523657611433 0.00920214147361355 no 104 0.0111494797980606 175 721395
SGTC_1709 st033179 39.1045 µM 2.28498435992927 0.00920863085497789 no 105 0.0111568724250403 150 573381
SGTC_3308 9128332 17.569 µM 2.28092863101577 0.00931353391841707 no 106 0.011276335207679 255 17332805 YDL196W YDL196W
SGTC_1668 st014914 51.6 µM 2.2778629574541 0.00939352123605588 no 107 0.0113673719420755 107 2839556
SGTC_651 3253-0966 34.4 µM 2.27624937643488 0.00943586248457956 no 108 0.0114155440775 164 781462
SGTC_1956 st077085 54 µM 2.26709846501421 0.00967915893908188 no 109 0.0116921056673626 161 24208685
SGTC_2186 6124449 200 µM 2.25235372936307 0.0100827166458129 no 110 0.012149963643381 161 3834182 YLR033W RSC58
SGTC_2765 myclobutanil 7.74 µM 2.2494958017927 0.0101626136229344 no 111 0.0122404848106678 189 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1392 3455-1037 33.9 µM 2.24812873737431 0.0102010265337278 no 112 0.0122839910530281 141 981132
SGTC_1285 0929-0069 65.5 µM 2.24239828830764 0.010363426819428 no 113 0.0124678211698361 164 1206237
SGTC_377 3970-0964 33.1 µM 2.23802486615909 0.0104888811835455 no 114 0.0126097168010585 248 16481235
SGTC_609 0986-0026 86.3 µM 2.21032752407084 0.0113145480041031 no 115 0.0135412198661385 201 2848610
SGTC_1488 4013-0813 75.9 µM 2.20923784590188 0.0113481554389691 no 116 0.013579050892731 112 2910057
SGTC_2221 6807166 181.081 µM 2.19532932284975 0.0117847958403573 no 117 0.0140699914747412 81 674925
SGTC_1965 Pectolinarigenin 58.4 µM 2.18190952331521 0.0122198390160493 no 118 0.0145581054279089 145 5320438 An anti-inflammatory.
SGTC_1888 azatryptophan 97.5 µM 2.17687654090339 0.01238655061588 no 119 0.0147448900953744 138 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3338 9144300 39.5675 µM 2.16912743361571 0.0126470816731641 no 120 0.0150365052262234 178 4901274
SGTC_1795 st049545 62.3 µM 2.15936323026234 0.0129821041188776 no 121 0.0154109990949316 133 5291882
SGTC_643 k048-0106 28.4 µM 2.15512557895986 0.0131298744727134 no 122 0.0155760042880194 146 6763920
SGTC_896 0964-0007 44.5 µM 2.1535523737714 0.013185102236576 no 123 0.0156376463195761 132 6756758
SGTC_145 3737-0113 38.366 µM 2.12851831308006 0.0140913148012884 no 124 0.0166470666186216 282 6849351
SGTC_444 curcumin 90.4 µM 2.1182061782342 0.0144799310731426 no 125 0.0170788050927572 192 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1223 0764-0573 147 µM 2.11794719255355 0.0144898086316829 no 126 0.0170897701086036 220 1609797
SGTC_2665 lovastatin 100 µM 2.11200969874456 0.0147178570577926 no 127 0.0173428087124255 173 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_683 panaxydol 45 µM 2.11030052572018 0.0147840729247081 no 128 0.0174162391738032 192 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_3129 9127257 49.47 µM 2.10730864687135 0.0149005995832729 no 129 0.0175454171620764 184 837894
SGTC_2678 equilin 100 µM 2.10631930247274 0.0149393055649117 no 130 0.0175883128602504 193 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_857 0438-0306 1.35 µM 2.08794512097771 0.0156740222593181 no 131 0.0184013926822738 164 4686136
SGTC_2115 tiliquinol 12.7705 µM 2.0734621995672 0.016274788901008 no 132 0.0190646427555053 154 71208 A bioactive hydroxyquinoline.
SGTC_1459 k035-0031 35.7 µM 2.06023571356578 0.01684056172333 no 133 0.0196880061362606 164 3877128 YMR208W ERG12
SGTC_558 k064-0027 21.3 µM 2.05793410999862 0.0169407135150289 no 134 0.0197982294251179 210 5088526
SGTC_2207 7258803 200 µM 2.04789610769978 0.0173834812665228 no 135 0.0202850901709846 142 3666799
SGTC_1233 0325-0408 14.2 µM 2.03328375804723 0.0180456628636413 no 136 0.0210119315697314 209 12874
SGTC_2231 micatex 6.853 µM 2.01987717976553 0.0186720010604 no 137 0.0216980644545203 161 20737 An antifungal of unknown mechanism.
SGTC_3166 9102297 49.47 µM 2.01780052084227 0.0187706561827461 no 138 0.0218060203169143 244 25237072
SGTC_1919 st067113 52.3 µM 2.01254804568725 0.0190221653959341 no 139 0.0220810986740184 249 1268243
SGTC_3182 9108849 49.47 µM 2.01212845457784 0.019042380110911 no 140 0.0221031989381642 231 17133045
SGTC_918 glabranin 770.725 nM 2.00803224297981 0.0192406854746553 no 141 0.0223199327470121 233 124049 Also referred to as licorice root.
SGTC_1100 amiodarone 5.07 µM 1.99556417103923 0.0198551236109552 no 142 0.0229906913565091 238 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2954 9074818 52.69 µM 1.98300804305773 0.0204906499349202 no 143 0.0236832655671761 251 16648742
SGTC_3112 9123419 49.47 µM 1.97502994762925 0.0209033497111908 no 144 0.0241323747843244 226 17015854
SGTC_126 0417-1624 672.48 µM 1.9735957358381 0.0209782814216454 no 145 0.0242138644996101 306 41912 YDL195W SEC31
SGTC_61 0978-8327 98.565 µM 1.96572134326999 0.0213937483038622 no 146 0.0246654039980016 243 6150059 YHR072W ERG7
SGTC_219 mitoxanthrone 164.414 µM 1.96151252872668 0.0216186514015216 no 147 0.0249096324692632 251 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3004 9076122 71.4286 µM 1.96048642779367 0.0216737842549315 no 148 0.0249694813966951 244 44782551
SGTC_1021 4476-0760 85.3 µM 1.95347450212568 0.0220537264745713 no 149 0.025381697872927 248 746768
SGTC_1707 st032323 6.317 µM 1.94998373091354 0.0222449610222373 no 150 0.0255890290884435 300 3132057 YMR211W DML1
SGTC_1655 st012546 55.1 µM 1.94771311347067 0.0223701015552593 no 151 0.0257246500647791 221 720985 YLR208W SEC13
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.94667420354555 0.0224275566969534 no 152 0.0257869031013239 240 688801
SGTC_2456 5770359 74.46 µM 1.94074273405442 0.0227579752960053 no 153 0.0261447450843819 225 3118787
SGTC_2330 7979373 200 µM 1.93307176079174 0.0231913695553021 no 154 0.0266136791385536 292 1863007
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.92815716821013 0.023472669633486 no 155 0.0269177899792454 117 1241132 A phosphatase inhibitor.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.92390084616565 0.0237186061874402 no 156 0.0271835065827158 320 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2150 5556613 200 µM 1.9174577101437 0.0240950202872095 no 157 0.0275899043221478 252 743190
SGTC_3203 9113543 49.47 µM 1.9117816779541 0.024430765211566 no 158 0.0279521013966182 260 17018012
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.91077958063348 0.0244904466283563 no 159 0.0280164564306003 249 390807
SGTC_2320 7373003 200 µM 1.91057727110094 0.0245025103122754 no 160 0.0280294637770798 226 5415828
SGTC_66 0109-0187 42.4 µM 1.90786961986812 0.024664447754762 no 161 0.0282040348628032 265 759417
SGTC_497 capsazepine 133 µM 1.89982382362572 0.0251509526728323 no 162 0.0287281217072618 225 2733484 A calcium channel blocker.
SGTC_2147 5545932 89.7195 µM 1.89380800171147 0.025519943983503 no 163 0.0291252495870383 217 797404
SGTC_1802 st050112 57.9 µM 1.89158185852386 0.0256576327445459 no 164 0.0292733574490352 232 4662563
SGTC_2211 7117706 200 µM 1.89079715193244 0.0257063154902238 no 165 0.0293257137629446 208 822771
SGTC_2840 9008771 71.43 µM 1.88361537961424 0.0261554708152506 no 166 0.029808510002084 179 2992978
SGTC_3281 9140613 49.47 µM 1.88174399930913 0.0262735807445917 no 167 0.0299353913016309 221 16013766
SGTC_1950 st077106 7.18 µM 1.87897668854054 0.0264490531719023 no 168 0.0301238381603167 276 13831864
SGTC_2185 6113692 200 µM 1.86879513203473 0.0271031070304301 no 169 0.030825661197832 235 874150
SGTC_662 k832-1615 104 µM 1.86461045098096 0.0273758133241154 no 170 0.0311180134423242 254 5878478
SGTC_608 k048-0125 159 µM 1.86325815068021 0.0274644274422589 no 171 0.0312129774985315 261 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.85996253357353 0.0276813861162278 no 172 0.0314454134628536 247 165521
SGTC_2913 7966556 36.57 µM 1.85522572881471 0.0279957220782135 no 173 0.0317819995224721 227 2976516
SGTC_1270 0831-1170 17.3 µM 1.85466907575809 0.0280328562017075 no 174 0.0318217486834313 266 6764716
SGTC_1140 3229-1848 2.98 µM 1.84755305350486 0.0285111878072736 no 175 0.0323335132436171 208 2849525
SGTC_1260 0700-1617 7.75 µM 1.8432024385079 0.0288069622578884 no 176 0.0326497295027385 309 2853078
SGTC_253 dyclonine 31.25 µM 1.82753142235087 0.0298935682880525 no 177 0.0338099530731952 313 3180 An oral anasthetic.
SGTC_2362 9071156 126 µM 1.82222370177127 0.0302692190426768 no 178 0.0342105248211658 274 653133
SGTC_91 0417-1751 58.384 µM 1.82200731410422 0.030284616376374 no 179 0.0342269379337485 364 6795624
SGTC_2181 6316240 54.2555 µM 1.82073392260202 0.0303753576792558 no 180 0.0343236564874674 258 12779990
SGTC_2569 tetrandrine 100 µM 1.81647815979446 0.0306802574340397 no 181 0.0346485276041518 240 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1952 st077036 64.1 µM 1.81598151329419 0.0307160037232121 no 182 0.0346866040010745 300 2937007
SGTC_2935 9038016 29.96 µM 1.79611078798617 0.0321747449511241 no 183 0.0362384495293067 297 6463195
SGTC_2838 9002687 71.43 µM 1.79370563982675 0.0323551283234618 no 184 0.0364300823290474 272 6457060
SGTC_1534 6-azauridine 81.6 µM 1.79240463516478 0.0324530494605653 no 185 0.0365340864290887 338 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1481 3346-2004 36 µM 1.78905188135928 0.0327065244442726 no 186 0.0368032302727595 288 2770522
SGTC_1524 corynanthine 62.1 µM 1.78045041106478 0.0333642866748628 no 187 0.0375011389844676 282 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_87 0100-0052 35.5 µM 1.78018773270079 0.0333845440945209 no 188 0.0375226211656078 537 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1815 st051655 58.2 µM 1.77395565431075 0.0338681320641774 no 189 0.0380352429050551 236 5984156
SGTC_3259 9138485 49.47 µM 1.77194000137956 0.0340257676370839 no 190 0.0382022586830093 323 17646153
SGTC_144 4161-2749 112.381 µM 1.76385317092208 0.0346642813867626 no 191 0.0388783514100067 247 797501 YMR168C CEP3
SGTC_1174 0739-0097 51.1 µM 1.76119684661992 0.0348761522237689 no 192 0.0391025457999329 316 728447
SGTC_2888 9058547 12.99 µM 1.75620358615155 0.0352772963472895 no 193 0.0395268262992285 227 16476514
SGTC_1947 st076332 61.6 µM 1.75545641284842 0.0353376463520056 no 194 0.0395906349758776 241 24208416
SGTC_1961 st076550 68.7 µM 1.75041836118755 0.035746789111016 no 195 0.0400230749932662 265 1579337
SGTC_1812 st052057 4.327 µM 1.74418416517052 0.0362584368243117 no 196 0.040563490792789 311 3645418
SGTC_1400 3771-8998 51.5 µM 1.74282902791203 0.0363704440336181 no 197 0.0406817420929991 255 670767
SGTC_2461 5755302 26.15 µM 1.73961521264802 0.0366372104584988 no 198 0.0409633031073268 336 2788904
SGTC_1331 1472-0049 76.2 µM 1.73916149670728 0.0366750002814339 no 199 0.0410031799942531 320 24051409
SGTC_529 4076-0302 30.3 µM 1.73634117381447 0.0369106195233924 no 200 0.0412517635285033 316 5816522
SGTC_2808 7946468 45.46 µM 1.73289143769229 0.0372005032604813 no 201 0.0415574832133783 361 2970879
SGTC_2700 st077718 96.8 µM 1.71649166865899 0.0386041328712484 no 202 0.0430360457674269 273 904970
SGTC_2787 5284540 71.43 µM 1.71009418016864 0.0391632552656547 no 203 0.04362422940842 318 736958
SGTC_1416 3966-0321 25.3 µM 1.71008195111185 0.039164330329064 no 204 0.0436253599261487 327 582530 YLR208W SEC13
SGTC_2998 9066762 71.4286 µM 1.70909012513861 0.0392516023295836 no 205 0.0437171282329701 383 4945196
SGTC_1805 st050013 60.3 µM 1.70874530862255 0.0392819802138937 no 206 0.0437490687085619 267 4037144
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.69469853032587 0.0405358368789463 no 207 0.0450663123121019 403 368090
SGTC_816 0325-0417 81.3 µM 1.69405993544782 0.0405936030610976 no 208 0.0451269472503585 287 68101
SGTC_1108 betulinic acid 729.144 nM 1.68895178668027 0.0410580859691621 no 209 0.0456143348955401 313 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1855 st056195 39.6 µM 1.68656013555513 0.0412770349096355 no 210 0.0458439813723178 329 4028379
SGTC_2038 4100038 30.985 µM 1.68211592310143 0.0416864030486237 no 211 0.0462731816408981 358 3596803
SGTC_1158 4092-0494 91.8 µM 1.67875973324617 0.0419977249320223 no 212 0.0465994395867679 339 1148199
SGTC_3173 9105693 49.47 µM 1.67624974510745 0.0422317806686515 no 213 0.0468446420315319 356 17096658
SGTC_202 3594-0513 34.79 µM 1.67581684994907 0.0422722545407626 no 214 0.0468870363029028 271 708429
SGTC_634 1611-4317 11.2 µM 1.67550065557354 0.0423018372102979 no 215 0.046918021280191 362 2843522
SGTC_2743 auranofin 4.32 µM 1.67511842820446 0.0423376201855051 no 216 0.0469554989800539 304 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1471 k673-0312 37 µM 1.67388171723328 0.0424535651567642 no 217 0.0470769240090498 307 24099884
SGTC_3301 9125354 19.7965 µM 1.67287400004568 0.0425482311160436 no 218 0.047176051583908 285 41905162
SGTC_3081 9117243 49.47 µM 1.66363933174061 0.043423717140368 no 219 0.0480922634435486 311 45595589
SGTC_397 arbidol 50 µM 1.66270536475073 0.0435130651870831 no 220 0.0481857139072456 353 131410 A RNA synthesis inhibitor.
SGTC_1664 st014217 9.02 µM 1.66009854816834 0.043763231850434 no 221 0.0484473144751269 347 3982782
SGTC_2311 7694451 200 µM 1.65754054604683 0.0440098406656678 no 222 0.0487051192497404 359 2163142
SGTC_593 1203-0218 61.7 µM 1.65713962786407 0.0440485932934244 no 223 0.0487456244663118 331 3666956
SGTC_1995 st072814 61.1 µM 1.65688452458888 0.0440732658179455 no 224 0.0487714118514718 322 5769371
SGTC_2021 4019055 173 µM 1.65258910716641 0.0444903764959982 no 225 0.049207258237581 547 44827708 YER133W GLC7
SGTC_3189 9110682 49.47 µM 1.6493887729221 0.0448032109262181 no 226 0.0495340066513369 343 17122418
SGTC_730 1436-0052 41.2 µM 1.64920908153413 0.0448208282410279 no 227 0.0495524040423465 294 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_339 3091-4833 71.4 µM 1.64350108581701 0.0453833605257407 no 228 0.0501396504382954 306 3240077
SGTC_1153 4055-0057 267 µM 1.63988819221549 0.045742342191433 no 229 0.0505142081995739 362 882706
SGTC_2699 st077704 54.6 µM 1.63908575346309 0.0458223824596094 no 230 0.0505977008221955 360 645852
SGTC_3018 9082602 49.47 µM 1.63788200019342 0.0459426633775929 no 231 0.0507231557484284 369 17332089
SGTC_486 niguldipine 82 µM 1.63787147086896 0.0459437166023263 no 232 0.0507242542044051 292 1236 A calcium channel blocker.
SGTC_2592 piperlongumine 83.33 µM 1.63722788167177 0.0460081302283172 no 233 0.0507914316563508 333 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_737 1950-0117 57.9 µM 1.63546446843034 0.0461849932281197 no 234 0.0509758586770596 349 5393513
SGTC_251 melphalan 456.522 µM 1.62878676825073 0.0468596928952286 no 235 0.0516790833721438 405 460612 A DNA alkylator.
SGTC_2285 7945142 200 µM 1.62714589737841 0.0470266869927824 no 236 0.0518530575458334 354 2970608
SGTC_1001 4048-4355 44.4 µM 1.62692987669807 0.0470487072707742 no 237 0.0518759958795505 349 21824233
SGTC_1531 st059297 52.4 µM 1.6266784483625 0.0470743472727501 no 238 0.0519027041582346 358 7566702
SGTC_11 0438-0307 1.3 µM 1.6250621719959 0.0472394384878005 no 239 0.0520746560530373 324 4011476
SGTC_1454 4239-0054 42.6 µM 1.62468724686214 0.0472778006746176 no 240 0.0521146080608253 411 1340767
SGTC_720 r052-1644 49.9 µM 1.62432867238444 0.0473145132234402 no 241 0.0521528405175264 314 1422863 YOR257W CDC31
SGTC_2149 5554786 194.827 µM 1.62124915263966 0.0476307504706044 no 242 0.0524821075669015 402 745063 YPR165W RHO1
SGTC_358 0075-0058 9.45 µM 1.6175616013207 0.0480116515433343 no 243 0.0528785549845949 483 1069125
SGTC_3028 9087778 49.47 µM 1.61548535254817 0.0482271855286545 no 244 0.0531028149077865 330 17217395
SGTC_1955 wogonin 32.4 µM 1.60934909339227 0.0488687138182756 no 245 0.0537700149430285 345 5281703 A flavanone.
SGTC_1366 1683-0113 21.9 µM 1.60700412973888 0.0491156666831843 no 246 0.0540267310942024 343 708623
SGTC_2087 5276107 200 µM 1.60139828358722 0.0497100700127116 no 247 0.0546443663357531 333 144405
SGTC_679 0422-0091 41.4 µM 1.60081349727797 0.0497724057009466 no 248 0.054709116610908 403 627384 YHR062C RPP1
SGTC_1207 2099-0101 141 µM 1.59521586840626 0.0503722488646526 no 249 0.0553319857226337 404 5837381
SGTC_2075 5212009 200 µM 1.59464187798669 0.050434082073724 no 250 0.0553961710820523 312 780898
SGTC_1329 1447-1697 50.6 µM 1.59446042456558 0.0504536417486078 no 251 0.0554164739827967 387 2840515
SGTC_335 4077-0256 27.6 µM 1.59242930209143 0.0506729982295419 no 252 0.0556441383173406 416 3121989
SGTC_2784 7567673 72.73 µM 1.58612571116874 0.051358610929599 no 253 0.0563553977405466 422 3471247
SGTC_1871 st057448 67.3 µM 1.58434553668238 0.0515535626938444 no 254 0.0565575542788563 394 691747
SGTC_2657 nystatin 74.44 µM 1.58044767227259 0.0519824831448804 no 255 0.0570021907399258 372 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1251 0490-5699 265 µM 1.5750740779021 0.0525784358865816 no 256 0.0576196733310073 439 3883818
SGTC_2346 9031566 143.75 µM 1.56760724776474 0.0534155243859547 no 257 0.0584864098081228 353 4771086
SGTC_227 fluconazole 33.516 µM 1.56572131817226 0.0536286133583701 no 258 0.0587069366292832 464 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1900 st060200 72.8 µM 1.56547747557182 0.05365621394041 no 259 0.0587354973871087 378 688945
SGTC_2783 7738165 71.43 µM 1.5616498763293 0.054090936657538 no 260 0.0591852464190282 304 17201110
SGTC_1432 4049-0298 68.4 µM 1.55287659401558 0.0550978870968721 no 261 0.060226309774274 358 741646
SGTC_650 1328-0195 38 µM 1.55112272865015 0.0553009515102634 no 262 0.0604361376561104 402 2780821
SGTC_1419 3993-2473 62.6 µM 1.55094010460537 0.0553221298497866 no 263 0.0604580191637616 380 704026
SGTC_3045 9092950 49.47 µM 1.54916772323353 0.055528000248631 no 264 0.0606707031457778 421 44120432
SGTC_1740 st038286 13.222 µM 1.5481176565172 0.0556502554212559 no 265 0.0607969858933312 412 716786
SGTC_50 0929-0078 56.389 µM 1.54744222237448 0.0557290057899811 no 266 0.0608783232808041 391 1377751
SGTC_2649 anisomycin 9.56 µM 1.54624293751917 0.0558690497480717 no 267 0.0610229536443792 342 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_264 promethazine 12.5 mM 1.54325009061631 0.0562197441813012 no 268 0.0613850540158345 518 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_972 1319-0219 195 µM 1.54214231515204 0.0563499898305696 no 269 0.0615195070496837 405 23903702
SGTC_2010 4012422 159 µM 1.53816947250292 0.0568190500108647 no 270 0.0620035915265509 405 952393
SGTC_1273 0849-0096 14.1 µM 1.53669042977162 0.0569944591060956 no 271 0.0621845679052059 419 5286025
SGTC_359 0081-0058 15.9 µM 1.53555796144353 0.0571290537169634 no 272 0.0623234156064422 391 3494159
SGTC_207 4185-0010 4.486 µM 1.53324411678741 0.0574048334283745 no 273 0.0626078590006306 491 3761753
SGTC_2858 9025781 8.96 µM 1.53131138142602 0.0576359918489966 no 274 0.0628462269988612 541 4894980 YPL153C RAD53
SGTC_3224 9130643 49.47 µM 1.53020128148993 0.0577690922841745 no 275 0.0629834571409091 405 17644395
SGTC_1388 3346-4487 254 µM 1.51915190932898 0.0591071165524268 no 276 0.0643621315346161 451 3345614
SGTC_792 4534-1957 155 µM 1.51560708871703 0.0595414890982427 no 277 0.0648093667706322 385 1717904
SGTC_842 0271-0008 11.1 µM 1.51482369101245 0.0596378212116055 no 278 0.0649085295912858 446 1221709
SGTC_1993 st073995 70.8 µM 1.51465443733801 0.0596586498734586 no 279 0.0649299692597738 402 3098394
SGTC_2949 9072542 2.23 µM 1.51442418937985 0.0596869937527401 no 280 0.0649591440098264 472 16457352
SGTC_417 st075190 100 µM 1.51214473237364 0.0599681680443634 no 281 0.0652485236195749 423 222757
SGTC_1373 2887-0003 58.5 µM 1.51138269748864 0.0600623971537048 no 282 0.0653454875510112 409 776948
SGTC_649 1123-0311 367 µM 1.51131170629397 0.0600711814407679 no 283 0.0653545264026506 478 693629 YIL048W NEO1
SGTC_1178 0988-0033 191 µM 1.51021699005595 0.06020676650512 no 284 0.0654940323924938 448 5392207
SGTC_412 gemfibrozil 100 µM 1.50316038168576 0.0610865133878541 no 285 0.0663988455967037 342 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2335 9018011 154.17 µM 1.50163445514565 0.0612780653166177 no 286 0.0665957699495267 473 6458208
SGTC_1478 0453-0656 35.7 µM 1.5007398519908 0.0613905842734049 no 287 0.0667114305785324 424 5258496
SGTC_293 4049-0273 38.5 µM 1.49972284199479 0.0615186949452127 no 288 0.0668431055697084 366 1380311
SGTC_3351 9150312 21.596 µM 1.49765118919381 0.0617803025708691 no 289 0.0671119498495165 439 4904905
SGTC_2761 levamisole 97.89 µM 1.495221668539 0.0620882071465191 no 290 0.0674283001148279 399 26879 An alkaline phosphatase inhibitor.
SGTC_1879 gemcitabine 100 µM 1.49445467995915 0.0621856594645219 no 291 0.0675284094384778 412 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2488 5268135 45.7 µM 1.49095858929198 0.0626313792797847 no 292 0.0679861837141423 525 1270356 YLR208W SEC13
SGTC_2398 5228213 48.84 µM 1.48947118192083 0.0628217636405659 no 293 0.0681816682431284 520 80771 YMR134W ERG29
SGTC_1315 1237-0019 3.69 µM 1.48763078906877 0.0630579530474924 no 294 0.0684241445384942 433 825140
SGTC_606 k015-0008 38.6 µM 1.48700434273803 0.0631385065077789 no 295 0.068506831987168 458 1970475
SGTC_1994 st072947 40.9 µM 1.48424623874829 0.0634941189458346 no 296 0.0688718035204578 432 5286565 YDL195W SEC31
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.48409393945365 0.0635138007723906 no 297 0.0688920004112181 445 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2282 7944268 200 µM 1.48225689158183 0.0637515789449522 no 298 0.0691359769635233 470 2970414
SGTC_3303 9125618 40.5795 µM 1.48103613737593 0.0639099697728343 no 299 0.0692984720058185 523 22695467
SGTC_3354 9151612 71.43 µM 1.48009658112128 0.0640320839160737 no 300 0.0694237369230923 456 27261949
SGTC_2263 7948595 193.29 µM 1.479373323642 0.0641262092198169 no 301 0.0695202828684836 358 2971371
SGTC_1626 st003712 1.76 µM 1.47567953293284 0.0646086004470387 no 302 0.0700149714658752 408 24207035
SGTC_1335 1486-0900 202 µM 1.47496954999314 0.0647016429104186 no 303 0.0701103650364073 475 X1335
SGTC_1658 st012944 20 µM 1.47222476293881 0.0650623231841663 no 304 0.07048009626034 464 24207260
SGTC_1828 st055811 49 µM 1.46509312436956 0.0660067549120412 no 305 0.0714477561506611 376 5877589
SGTC_471 1-acyl-paf 4 µM 1.46314256526621 0.0662669055105247 no 306 0.0717141863908558 432 16759367
SGTC_554 4483-2211 187 µM 1.45734959939863 0.0670442090210215 no 307 0.0725099509949913 448 747107
SGTC_817 1391-0715 46 µM 1.45373453732006 0.0675328417685426 no 308 0.073009959459083 419 1353946
SGTC_1381 2324-0066 62.1 µM 1.45283862628252 0.0676543627743195 no 309 0.0731342822926824 471 10885928
SGTC_1934 st074720 32.6 µM 1.45054390760117 0.0679663879665384 no 310 0.0734534521657681 516 17250992
SGTC_2522 biochanin a 4.94 µM 1.4503704356408 0.0679900209792318 no 311 0.0734776234285568 399 5280373 A possible chelator.
SGTC_1636 st007707 68.9 µM 1.44735770596715 0.0684014739640283 no 312 0.0738983823976576 508 403051
SGTC_1231 0242-0792 125 µM 1.444624219684 0.0687764501490699 no 313 0.0742817329973705 455 3707635
SGTC_1354 1498-1681 81 µM 1.44045295042929 0.0693517117443118 no 314 0.0748696460762028 498 5754243
SGTC_2650 prasterone 100 µM 1.43807934032832 0.0696807079201057 no 315 0.0752057718861426 351 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2453 5731132 22.18 µM 1.43507607091618 0.0700986988093514 no 316 0.0756327107780582 483 1362040
SGTC_183 3914-0051 30.55 µM 1.42669468648411 0.0712754119674485 no 317 0.0768339589465682 465 1596232
SGTC_942 3253-1115 227 µM 1.42421793688776 0.0716260245128765 no 318 0.0771916970682957 468 46497897
SGTC_1606 st000094 49.2 µM 1.42105408318255 0.0720758275095827 no 319 0.0776505186280847 480 1242210
SGTC_3210 9128157 49.47 µM 1.41877304837707 0.0724014618408124 no 320 0.0779825963026171 472 17590849
SGTC_807 1315-0151 48 µM 1.41445466491918 0.0730210278992839 no 321 0.078614224705634 539 4011080
SGTC_890 0929-0006 47.2 µM 1.41098589909452 0.0735216300431132 no 322 0.079124385933065 434 1378169
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.40997798632187 0.0736675800116991 no 323 0.0792730915703399 515 5106787 A p450 inhibitor.
SGTC_413 propylparaben 100 µM 1.40571794339294 0.0742868993794535 no 324 0.0799039482973517 456 7175 A pharmaceutical preservative.
SGTC_9 0092-0002 10.449 µM 1.40571279634474 0.0742876500478908 no 325 0.0799047127975462 482 759368
SGTC_331 k048-0133 24.5 µM 1.40439031467225 0.0744807186865071 no 326 0.0801013266973943 420 6813582
SGTC_1837 st055472 66.5 µM 1.39872790359951 0.0753117055086291 no 327 0.080947296658507 486 676091
SGTC_332 4112-0506 40.9 µM 1.39688671369776 0.07558342636846 no 328 0.0812238202924807 480 2790355
SGTC_1714 st033236 13.627 µM 1.39319377902698 0.0761306764953976 no 329 0.081780600234458 513 2916566
SGTC_1009 4106-0057 9.87 µM 1.39049098966894 0.076533106283194 no 330 0.0821899167588145 507 2928005
SGTC_246 cycloheximide 667 µM 1.38586125726785 0.0772262037344511 no 331 0.0828946364823606 410 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2588 indole-3-carbinol 100 µM 1.38423723541023 0.0774704556104853 no 332 0.0831429126833417 544 3712 Induces cell cycle arrest.
SGTC_2327 6189656 200 µM 1.38250064109283 0.0777322869243327 no 333 0.083409016882256 457 5349088
SGTC_2851 9015922 71.43 µM 1.38132206438375 0.0779103665971401 no 334 0.0835899784791189 500 2996893
SGTC_3356 9151811 4.48 µM 1.3802750887102 0.0780688212298308 no 335 0.0837509810172861 488 1859254 YPR165W RHO1
SGTC_2915 7971052 15.16 µM 1.37927556893706 0.0782203216423383 no 336 0.0839049030914124 338 5741558
SGTC_107 0358-0022 2.6945 µM 1.36815059595856 0.07992165260965 no 337 0.0856324710653727 350 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1173 0443-0020 122 µM 1.36640404496775 0.080191273256404 no 338 0.0859060899487601 508 5331295
SGTC_2354 9060492 162 µM 1.36406620990863 0.080553247600483 no 339 0.0862733641746773 562 6471895
SGTC_926 2268-1401 59.4 µM 1.36249808758893 0.0807967355857175 no 340 0.0865203736392731 514 2931578
SGTC_1408 3909-7976 48.8 µM 1.36119083620101 0.0810001415912863 no 341 0.0867266946774064 553 24152374
SGTC_3061 glucosamine 200 µM 1.3605491830575 0.0811001229925953 no 342 0.0868281000194501 472 91431 and experimental redox chemotherapeutic
SGTC_1637 st007924 17.4 µM 1.35999003438932 0.081187324588832 no 343 0.0869165387644308 506 683336
SGTC_2687 chenodiol 100 µM 1.35926308954064 0.0813008004626554 no 344 0.0870316178859068 480 5702181 A cholesterol synthesis inhibitor.
SGTC_2929 9013348 24.6 µM 1.35270108415045 0.0823305478908659 no 345 0.0880755719802652 512 2995952
SGTC_2369 9071472 200 µM 1.348582440746 0.0829818673914379 no 346 0.0887355619130095 515 17296037
SGTC_1689 st020265 53.493 µM 1.34354787047399 0.0837832861815451 no 347 0.0895473181351296 510 5758320 YPR016C TIF6
SGTC_316 k060-0003 58.6 µM 1.33895279374555 0.0845198069842692 no 348 0.0902930205969519 502 6152314
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.33501598524182 0.0851546716349503 no 349 0.0909355573357173 505 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1733 st037357 54.9 µM 1.32792780966303 0.0863067361943419 no 350 0.0921009782971571 551 1272339 YGL099W LSG1
SGTC_72 0744-0168 198.391 µM 1.32684728663111 0.0864833762384657 no 351 0.0922796023161191 514 677577
SGTC_2288 7946289 167.31 µM 1.32422194346619 0.0869136839033548 no 352 0.0927146725922374 585 1246052
SGTC_234 nsc-17383 10.7 µM 1.32403257034912 0.086944784900627 no 353 0.0927461139516534 583 408974
SGTC_1487 3970-0795 2.82 µM 1.32375664116796 0.0869901159956788 no 354 0.0927919402097805 552 3765103
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.32135928703927 0.0873847091889041 no 355 0.0931907971567916 577 676296 Flavone; oxidizing agent.
SGTC_3305 9127027 53.8275 µM 1.3190117354489 0.0877723983573229 no 356 0.0935825945816502 526 41905295
SGTC_1713 st033146 12.748 µM 1.31484443753526 0.0884637697424498 no 357 0.0942810946859802 546 674619
SGTC_2505 galangin 7.89 µM 1.31242788419499 0.0888665398253832 no 358 0.0946879018302712 448 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2091 4-phenylthiadiazole 200 µM 1.31238165079316 0.0888742588949649 no 359 0.0946956974410149 550 270010
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.30995625975097 0.089279899406268 no 360 0.0951053165286524 519 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1458 k015-0034 6.33 µM 1.30985468333032 0.089296917808346 no 361 0.0951224999788513 498 3598957
SGTC_900 1112-0045 141 µM 1.30905515736607 0.0894309569307579 no 362 0.0952578337896467 414 56211 YIL048W NEO1
SGTC_1550 gossypolone 36.6 µM 1.3062299134836 0.0899058028932828 no 363 0.0957371915326926 567 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3021 9087658 49.47 µM 1.30552107601141 0.0900252325276346 no 364 0.0958577376435733 485 25237042
SGTC_2156 5649887 115 µM 1.29919484373621 0.0910963431102377 no 365 0.0969385353024577 643 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_605 1315-0399 119 µM 1.2974775464972 0.0913887276919531 no 366 0.0972334629531936 598 24020461
SGTC_886 0866-0150 153 µM 1.29425070079825 0.0919400065028369 no 367 0.0977894195474353 575 271463
SGTC_1998 st075797 76.8 µM 1.29184674017957 0.0923523004843899 no 368 0.0982051125635276 601 24208315
SGTC_1230 0170-0365 3.77 µM 1.28789176675224 0.0930335773104796 no 369 0.0988918209410976 715 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1238 0333-0287 48.8 µM 1.28546970700138 0.0934526271421351 no 370 0.0993140979684437 548 7226
SGTC_1379 2144-0755 36.5 µM 1.28281083275698 0.0939142526429998 no 371 0.0997791789933033 598 5392327
SGTC_637 1181-0519 7.26 µM 1.28082923265656 0.0942593848483921 no 372 0.100126826899131 667 6252091 YGR060W ERG25
SGTC_1383 3049-0032 20.7 µM 1.27902396318712 0.0945746193635745 no 373 0.100444308750482 571 712864
SGTC_1246 0422-0085 105 µM 1.27653411693228 0.0950106682211829 no 374 0.100883387260383 614 264295
SGTC_203 k066-0004 30.888 µM 1.2742745237953 0.0954076728998562 no 375 0.101283070989873 659 6795412
SGTC_2389 9091542 195.52 µM 1.27150959849168 0.0958951227726918 no 376 0.101773707458268 598 3626624 YOL127W RPL25
SGTC_2741 miltefosine 3.04 µM 1.26847401340929 0.0964323960161205 no 377 0.102314362568745 452 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2627 acetyl isogambogic acid 100 µM 1.26421206935202 0.0971904526469934 no 378 0.103076959986303 539 6857789 A caspase activator and apoptosis inducer.
SGTC_2928 9011484 9.79 µM 1.25859858278049 0.0981955639363291 no 379 0.104087679597381 530 2994751
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.25446336882693 0.0989408421035298 no 380 0.104836816075635 658 65057 A dermal irritant. YDR527W RBA50
SGTC_1304 1165-0502 251 µM 1.25386841062348 0.0990484093950432 no 381 0.104944919304403 633 767425
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.25340955060728 0.0991314288062593 no 382 0.105028348750095 557 803109
SGTC_539 4859-0462 2.54 µM 1.25186820352823 0.0994106701401479 no 383 0.105308946313656 578 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_143 4032-1194 15.74 µM 1.25122483248984 0.0995273977227611 no 384 0.105426230359355 674 1806963
SGTC_2084 5306078 60.6385 µM 1.25114111711747 0.099542593665604 no 385 0.105441498291181 564 679340
SGTC_1377 2944-0135 198 µM 1.24506978842748 0.100649181202378 no 386 0.106553049125784 600 1894137
SGTC_1854 st056233 32.9 µM 1.24501825459538 0.100658612239184 no 387 0.106562520108613 568 5393174
SGTC_3162 9099653 49.47 µM 1.24368113370088 0.100903539703345 no 388 0.106808471131513 524 25237511
SGTC_943 3253-1379 105 µM 1.23548844235481 0.102413730070017 no 389 0.108324387624029 591 668464
SGTC_805 3852-0218 479 µM 1.22915746816674 0.103591951453697 no 390 0.109506385975592 583 6615355
SGTC_1465 k213-0056 144 µM 1.22888907393672 0.103642117208008 no 391 0.109556699266508 580 24048857 YMR208W ERG12
SGTC_1817 st052116 64.4 µM 1.2287740959482 0.103663613216983 no 392 0.109578258164707 562 4361398
SGTC_2651 TUB2.036 5 µM 1.22695896949131 0.104003393630806 no 393 0.109919006383378 782 15992207 YFL037W TUB2
SGTC_1429 4049-0205 9.46 µM 1.22543326703683 0.104289619770332 no 394 0.110206009554322 637 22774478
SGTC_958 1222-0007 33 µM 1.22435916843395 0.104491465893385 no 395 0.110408382689771 659 7312461
SGTC_1493 4348-0038 111 µM 1.21868966720047 0.105561577366885 no 396 0.111481000618063 657 800424
SGTC_941 3237-0776 460 µM 1.21811020921373 0.1056713941355 no 397 0.111591047385049 567 760008
SGTC_2951 9072950 58.06 µM 1.21529367668743 0.106206349675019 no 398 0.112127051384837 646 16488155
SGTC_1825 st052143 62.6 µM 1.21358486734966 0.106531862773053 no 399 0.112453144270174 566 674173
SGTC_2102 5377816 72.7585 µM 1.21279821286925 0.106681955367132 no 400 0.112603489433681 636 1379702
SGTC_2106 5357045 167.29 µM 1.20927347480426 0.107356344541513 no 401 0.113278898955225 618 668842
SGTC_2996 9066192 71.4286 µM 1.20732982306629 0.107729535938312 no 402 0.113652574884914 603 6472854
SGTC_2129 girgensonine 121.053 µM 1.20629504024087 0.107928600504085 no 403 0.113851874683724 664 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_711 k292-0785 179 µM 1.20322043697155 0.108521634503858 no 404 0.114445514160742 610 4146315
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.202046035143 0.108748772434949 no 405 0.114672846354662 442 6708630 An antioxidant.
SGTC_3056 9094900 49.47 µM 1.19785270023475 0.109562583352144 no 406 0.115487183255715 599 25236784
SGTC_1633 st005664 67.9 µM 1.19290698227782 0.110528020331022 no 407 0.116452902199568 639 2063822
SGTC_259 usnic acid 108.925 µM 1.19175555432166 0.110753659225471 no 408 0.116678553912084 647 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1455 4262-0120 131 µM 1.19089773313498 0.110921976063765 no 409 0.116846867286247 645 1529587
SGTC_2212 7123476 200 µM 1.19061678761205 0.110977141424261 no 410 0.116902029093905 524 1085715
SGTC_745 0469-0705 296 µM 1.19030051411179 0.111039267158048 no 411 0.116964149399347 712 3486736
SGTC_996 3970-0799 1.8 µM 1.19005948686909 0.111086628959719 no 412 0.117011506047695 816 6615648 YGL040C HEM2
SGTC_1789 tunicamycin 25 nM 1.18958786614524 0.111179344176005 no 413 0.11710420863581 627 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2993 9054257 71.4286 µM 1.18116474812651 0.112844571969366 no 414 0.118768641162212 643 6470217 YGL055W OLE1
SGTC_360 0957-0399 1.01 µM 1.1796377826959 0.113148345599716 no 415 0.119072154512565 668 6752301 YPR165W RHO1
SGTC_3103 9120822 49.47 µM 1.17454345310639 0.114166027899134 no 416 0.12008870884006 674 17141819
SGTC_2907 7721985 69.9 µM 1.17360832020468 0.114353543188134 no 417 0.120275973525611 620 3267881
SGTC_465 cgp-37157 41 µM 1.17315726809034 0.11444406768729 no 418 0.120366372304991 514 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3095 9117207 49.47 µM 1.17304312208497 0.11446698445674 no 419 0.120389256758888 590 17015229
SGTC_3187 9109394 49.47 µM 1.17225090947664 0.114626124746396 no 420 0.120548167197674 652 17098090
SGTC_3343 9148379 18.9835 µM 1.17209357379983 0.114657749191785 no 421 0.120579744834571 646 1955036
SGTC_345 1362-0200 395 µM 1.17183168716947 0.114710402129112 no 422 0.120632319006217 601 1419823
SGTC_2351 9026858 72.31 µM 1.17136418766004 0.114804436794754 no 423 0.120726210416628 592 1409300
SGTC_3298 9116858 71.43 µM 1.16625559510078 0.115835574077907 no 424 0.12175556040253 680 2506942
SGTC_910 3454-3003 490 µM 1.1656668673157 0.115954826373646 no 425 0.121874580526514 666 820824
SGTC_1396 3511-0007 98.6 µM 1.16264609503933 0.116568082931566 no 426 0.122486560307196 579 X1396
SGTC_2862 9027634 71.43 µM 1.15910852383058 0.117289176279866 no 427 0.123205975935937 615 5012562
SGTC_665 3914-0008 307 µM 1.15778911222633 0.117558930479666 no 428 0.123475053807064 643 1069549
SGTC_1505 k297-0037 20.6 µM 1.1566230619148 0.117797695254528 no 429 0.123713197927115 666 4089396
SGTC_303 1348-1668 34.2 µM 1.15315046712855 0.118510788665422 no 430 0.124424315149231 638 5380509
SGTC_2606 farnesol 9.78 µM 1.150838819249 0.118987171101387 no 431 0.124899275642075 668 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_594 1487-1584 10.8 µM 1.14963690346354 0.11923539449225 no 432 0.125146725995093 652 5013332
SGTC_1470 k295-0292 231 µM 1.14918255476441 0.119329323129846 no 433 0.125240356390673 698 5045612
SGTC_3088 9117578 49.47 µM 1.14914637571429 0.119336804758824 no 434 0.125247814129098 640 678341
SGTC_1212 0520-0165 585 µM 1.14699471143062 0.119782352511494 no 435 0.125691903331578 654 5403258
SGTC_3133 9127736 49.47 µM 1.1460001840143 0.119988686403684 no 436 0.12589753796025 683 27243420
SGTC_2373 9071805 200 µM 1.14393235028374 0.12041850005553 no 437 0.12632584678008 668 10149009
SGTC_1152 3909-8331 15.9 µM 1.14158702195258 0.120907303994957 no 438 0.12681286053709 627 16001939
SGTC_2397 5161689 200 µM 1.14092302650777 0.121045944522785 no 439 0.126950978102592 693 2259942
SGTC_2227 7312221 64.1025 µM 1.13951165709488 0.121341006222696 no 440 0.127244904511244 657 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_921 1561-0023 372 µM 1.13892409861184 0.121463990510168 no 441 0.127367406660053 681 24050882
SGTC_2008 4012253 172 µM 1.1379041011779 0.121677698426622 no 442 0.127580264290109 689 603940
SGTC_818 4072-2707 53.5 µM 1.13781797226703 0.121695756081967 no 443 0.12759824937388 646 882871
SGTC_2462 5162487 171.77 µM 1.13605564251726 0.122065656968728 no 444 0.127966638868156 693 2259986
SGTC_1449 4112-4002 201 µM 1.13564129769678 0.12215273961347 no 445 0.128053358832126 640 2059539
SGTC_2617 dihydrotanshinone i 20.83 µM 1.1335091647142 0.122601538659348 no 446 0.128500247367298 706 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_340 k038-0059 454 µM 1.13216629717581 0.122884795900124 no 447 0.128782263248673 692 23733424
SGTC_3315 9136395 68.55 µM 1.13178513777717 0.122965279154124 no 448 0.128862388785315 730 16876844
SGTC_1736 st036774 51 µM 1.12901875592671 0.123550518708764 no 449 0.129444960812059 708 1272247
SGTC_2691 st077356 60.2 µM 1.1245058083379 0.124509433259542 no 450 0.130399253916608 709 2839272
SGTC_1128 3448-9350 235 µM 1.12218554684981 0.125004464361757 no 451 0.130891778285098 613 619386
SGTC_1710 st031758 61.5 µM 1.12215997941219 0.125009926858305 no 452 0.130897212663722 658 5394341
SGTC_3151 9099821 49.47 µM 1.12160740152022 0.125128026161589 no 453 0.13101470162317 660 17174189
SGTC_1772 st048439 82.2 µM 1.12034281212522 0.125398592732206 no 454 0.131283852377696 693 2927068 YDL195W SEC31
SGTC_2003 4023581 200 µM 1.11961730237223 0.125554004167256 no 455 0.131438439575378 662 16641307
SGTC_2638 epoxomicin 18 µM 1.116909363773 0.126135258497083 no 456 0.132016540268018 733 9915668 A protesome inhibitor.
SGTC_1297 1068-0111 14.1 µM 1.11446270655143 0.126662039990855 no 457 0.132540367455923 677 767057
SGTC_871 0574-0004 149 µM 1.11319766981564 0.126935010838188 no 458 0.132811771617135 743 9551173
SGTC_2406 ethylparaben 405.7 µM 1.11300576647376 0.126976455670491 no 459 0.132852976450628 587 8434 A possible steroid mimic.
SGTC_3148 9097893 49.47 µM 1.11045652790946 0.127527901326669 no 460 0.133401175500226 649 17174100
SGTC_1340 1486-1359 257 µM 1.10850212111933 0.127951800451117 no 461 0.133822511793844 708 4309068
SGTC_2837 9008476 45.46 µM 1.10739284834658 0.128192830103039 no 462 0.13406205830137 700 2992805
SGTC_1398 3558-0053 112 µM 1.10580814785995 0.12853771034294 no 463 0.134404783809905 626 4532369
SGTC_865 0488-0499 301 µM 1.10516367189153 0.128678152442974 no 464 0.13454433750757 757 9634651
SGTC_2083 5306046 65.942 µM 1.10436534992634 0.128852267745835 no 465 0.134717342619293 700 539837
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.10425724757207 0.128875857599882 no 466 0.134740781313322 828 688664
SGTC_2056 5235370 200 µM 1.10046617941725 0.129705031087035 no 467 0.135564528784061 673 5511916
SGTC_179 1273-0063 6.77 µM 1.10008022247883 0.129789653432971 no 468 0.135648585075829 640 3108139
SGTC_232 clozapine 119 µM 1.09928337647435 0.129964485502148 no 469 0.135822240477165 694 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2235 salicylic acid 500 µM 1.09744787714256 0.130367823460268 no 470 0.136222827011763 705 338 A COX inhibitor and kinase inhibitor.
SGTC_2796 7949634 45.45 µM 1.09706991518256 0.130450985310375 no 471 0.136305415184333 658 2971588
SGTC_2525 harmine 47.85 µM 1.09255249141905 0.131447780947399 no 472 0.137295165788832 673 5280953 A monoamine oxidase inhibitor
SGTC_1819 st053448 58.6 µM 1.08928682112796 0.132171636492529 no 473 0.138013711281427 710 2857616
SGTC_1911 st060208 74.3 µM 1.08871090282547 0.132299576786166 no 474 0.138140696161312 747 688783
SGTC_1255 0566-0045 221 µM 1.08768228274607 0.132528297143794 no 475 0.138367695934177 715 2788469
SGTC_1904 st060225 78 µM 1.0871868078724 0.132638566366128 no 476 0.138477129883744 708 66595
SGTC_1884 5633444 25 µM 1.08565414651465 0.132980064193772 no 477 0.138816017219965 728 5724239
SGTC_478 N-arachidonylglycine 10 µM 1.0854773491664 0.133019495954067 no 478 0.138855145251223 600 5283389
SGTC_530 4358-1714 28 µM 1.08341688229198 0.133479642970809 no 479 0.139311712771956 773 1564641
SGTC_3352 9151559 45.5865 µM 1.08092327702779 0.134037981864679 no 480 0.139865621714721 688 17159339
SGTC_2950 9072895 21.46 µM 1.08091299193153 0.134040288101063 no 481 0.139867909456808 720 17332245
SGTC_1026 k007-1105 30.6 µM 1.0793346155735 0.13439453201843 no 482 0.140219293492639 779 7066794
SGTC_986 1493-0483 84 µM 1.07887374458919 0.134498089038151 no 483 0.140322007314824 718 40079
SGTC_2747 doxorubicin 7.63 µM 1.07804010509957 0.134685545711899 no 484 0.140507929428885 540 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1431 4049-0260 9.09 µM 1.07623300150276 0.135092516148276 no 485 0.140911531948434 743 3854841
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.07460364241234 0.135460179710557 no 486 0.141276110203857 693 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_42 0133-0086 60.653 µM 1.07075504991081 0.136331332231105 no 487 0.142139791513642 650 162923 Model of phenazepam hydroxylation.
SGTC_742 0kpi-0133 140 µM 1.0670906040487 0.13716435709771 no 488 0.14296546214879 774 2728852
SGTC_57 miconazole 162.5 nM 1.06649449149579 0.137300197277297 no 489 0.143100083737406 696 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2541 muurolladie-3-one 83.07 µM 1.06450037692508 0.137755277165681 no 490 0.143551041870834 708 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_3215 9129942 49.47 µM 1.06338763349649 0.13800966493799 no 491 0.143803099274225 695 17682944
SGTC_2401 5128683 200 µM 1.05973203607197 0.138847636858195 no 492 0.144633261976911 672 708373
SGTC_621 3584-0052 32.1 µM 1.05929718717358 0.138947547296288 no 493 0.144732227790416 785 2273927
SGTC_811 0416-0114 265 µM 1.0551620405326 0.139900080194096 no 494 0.145675610829944 723 6612453
SGTC_2269 7935389 174.42 µM 1.05334643407596 0.140319704797203 no 495 0.146091122337854 715 97605
SGTC_139 0099-0334 718.624 µM 1.04294190639888 0.142740884240123 no 496 0.148487599657744 882 97690
SGTC_2259 7964009 200 µM 1.03934232127245 0.143585060684765 no 497 0.149322779378957 716 313134
SGTC_2415 st077333 57.7 µM 1.03921192352403 0.143615704743656 no 498 0.14935309315854 853 2766255
SGTC_592 k241-0073 46.5 µM 1.03684935596244 0.144171683273174 no 499 0.149903034673841 809 4230158
SGTC_435 c-PAF 6.7 µM 1.03644312287111 0.144267427348383 no 500 0.149997730589113 775 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1045 1348-1485 165 µM 1.03512036503226 0.144579481825713 no 501 0.150306351491165 854 6810614
SGTC_2077 5212015 200 µM 1.03406549958004 0.144828662949368 no 502 0.15055277181383 716 780900
SGTC_2426 5582046 32.21 µM 1.03328658978331 0.145012843115698 no 503 0.150734900523177 789 2251934
SGTC_2969 9091408 28.7 µM 1.03327296468418 0.145016066294354 no 504 0.150738087719179 730 4286311
SGTC_824 1304-0008 100 µM 1.03314020132177 0.14504747556525 no 505 0.150769146198551 771 768245
SGTC_301 4119-0100 24.5 µM 1.03066726435307 0.145633362149064 no 506 0.151348440479554 795 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1671 st016596 74.5 µM 1.0286388870107 0.146115110175193 no 507 0.151824698688366 816 2829167
SGTC_687 k029-0044 34.9 µM 1.02796234317546 0.146276029938327 no 508 0.151983770800207 836 5829338
SGTC_507 nimesulide 162 µM 1.02711728505839 0.14647719888223 no 509 0.152182620216504 784 4495 A COX2 inhibitor.
SGTC_285 1486-1325 46 µM 1.02560282922443 0.146838184666901 no 510 0.15253941666838 819 22310230
SGTC_1076 itraconazole 331 nM 1.02558205276836 0.146843141090342 no 511 0.152544315329689 805 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1653 st012112 65 µM 1.02471604672082 0.147049834994566 no 512 0.152748594608857 741 720429
SGTC_3269 9137823 49.47 µM 1.02271603806874 0.147527932069754 no 513 0.153221063068505 699 17682936
SGTC_214 4373-3496 70 µM 1.0196210106816 0.148269841173637 no 514 0.153954118220264 949 3779166
SGTC_3225 9130819 49.47 µM 1.01825167655053 0.148598879377314 no 515 0.154279183394573 783 4547121
SGTC_1310 1188-0297 994 nM 1.01686518353118 0.148932537736244 no 516 0.154608784028277 791 1588352
SGTC_1970 st070122 35.8 µM 1.01536001145636 0.149295322352155 no 517 0.154967123782517 763 102928
SGTC_1356 1502-0781 85.8 µM 1.01489055601942 0.149408593621531 no 518 0.155079000236653 767 567702
SGTC_2238 6671620 73.2395 µM 1.0107571055882 0.150408397734464 no 519 0.156066348889122 764 729941
SGTC_1190 1486-1332 13 µM 1.01066344295341 0.150431104496283 no 520 0.156088769780439 790 4150046
SGTC_2130 NSC 7 2.4545 µM 1.01045371384069 0.150481957696611 no 521 0.156138982275698 823 21448
SGTC_2443 5493264 126.67 µM 1.00962651638038 0.150682640630654 no 522 0.156337130306927 800 5340055
SGTC_365 0121-0052 13.6 µM 1.00859520666476 0.150933091884862 no 523 0.156584403543018 848 3101739
SGTC_772 k072-0172 35.3 µM 1.00518726885941 0.151762671465637 no 524 0.157403342157561 723 5861980
SGTC_561 1550-0330 72.9 µM 0.999510778649648 0.153151189633351 no 525 0.158773660132388 762 6812934
SGTC_934 2950-0684 338 µM 0.998960929524306 0.153286133304592 no 526 0.158906809191222 852 1121253
SGTC_74 000s-0487 160.283 µM 0.998062887672374 0.15350669960255 no 527 0.159124432390542 843 677548
SGTC_1767 st044992 70.3 µM 0.997421599405718 0.153664333735888 no 528 0.159279955719255 774 9600693
SGTC_290 2043-6722 48.1 µM 0.996172217970037 0.153971750056045 no 529 0.159583237785493 809 773758 YLR208W SEC13
SGTC_840 0245-0196 390 µM 0.995631805198145 0.15410484721528 no 530 0.159714537722075 856 3827528
SGTC_2310 7668677 200 µM 0.995569443164271 0.154120211130126 no 531 0.159729693893807 783 2197143
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.99520819564196 0.154209230345614 no 532 0.159817508285052 773 4330530
SGTC_2020 4017018 200 µM 0.994589095062226 0.154361869205414 no 533 0.159968076698651 788 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.994121758535155 0.154477156876239 no 534 0.160081796748161 833 3256 An antibiotic and ribosome inhibitor.
SGTC_1407 3909-7909 12.3 µM 0.993890002277091 0.154534350144132 no 535 0.160138211113419 837 4411780
SGTC_2591 skatole 100 µM 0.99324147781389 0.154694468666602 no 536 0.160296144723042 789 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_7 0192-1582 4.227 µM 0.992831669182433 0.154795705551349 no 537 0.160395996908471 908 252616
SGTC_610 4215-0184 155 µM 0.992712459916531 0.154825162572855 no 538 0.160425050548173 844 5605015
SGTC_3265 9137266 49.47 µM 0.988281034604349 0.155922810403472 no 539 0.161507515519542 791 17224265
SGTC_2938 9059746 27.26 µM 0.985926202595257 0.156508175839923 no 540 0.162084663878173 771 6471769
SGTC_746 1095-0025 46.6 µM 0.985723870078068 0.156558539185929 no 541 0.162134316362912 865 6749286
SGTC_230 MPP+ 141.667 µM 0.984871885786384 0.156770726839753 no 542 0.162343502319633 775 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3177 9107506 49.47 µM 0.982042032815469 0.157476862604096 no 543 0.163039570555797 792 8897194
SGTC_2596 sinensetin 100 µM 0.981302359301525 0.15766177805672 no 544 0.163221829820947 755 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.980536106619039 0.157853488565078 no 545 0.163410777884847 893 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.979581440564754 0.158092552735175 no 546 0.163646384955691 764 77254
SGTC_1417 3966-0327 90.4 µM 0.979384070909086 0.158142006991497 no 547 0.163695122352036 872 651118
SGTC_768 0384-0033 77.3 µM 0.977164114253541 0.158698953433467 no 548 0.164243955408132 826 3965305 YMR134W ERG29
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.977046121319459 0.158728591646734 no 549 0.164273159797043 838 94937 An inhibitor of serotonin biosynthesis.
SGTC_1932 st074806 40.9 µM 0.972848997654355 0.15978521188637 no 550 0.165314178241653 876 17251235
SGTC_2593 nobiletin 86.24 µM 0.971696401927202 0.160076179820373 no 551 0.165600803658139 762 72344 An anti-infammatory.
SGTC_653 0203-0016 55.2 µM 0.971445399453093 0.160139590246046 no 552 0.165663265088699 853 295302
SGTC_112 phenothiazine 287.218 µM 0.970273309139262 0.160435911236933 no 553 0.165955138897537 886 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2180 6301957 200 µM 0.969958935099808 0.160515450328851 no 554 0.166033480776039 869 845462
SGTC_2268 7933382 153.85 µM 0.965994948570775 0.161520579792709 no 555 0.167023354360676 946 935025 YOR257W CDC31
SGTC_3243 9134147 49.47 µM 0.963524943838037 0.162148957975158 no 556 0.167642076272613 893 24282180
SGTC_2412 st077135 33.4 µM 0.963500252741657 0.162155247505247 no 557 0.167648268692291 821 13258915
SGTC_2124 5246320 200 µM 0.961958307177415 0.162548339968623 no 558 0.168035273794813 817 579342
SGTC_1091 telmisartan 47.6 µM 0.961841876609399 0.16257804709216 no 559 0.168064519440173 869 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_54 0159-0055 9 µM 0.960707466659057 0.162867675327061 no 560 0.168349637942862 847 3319099
SGTC_55 0767-0285 6.563 µM 0.958361113779895 0.1634677908278 no 561 0.168940348328946 892 3116166
SGTC_140 0062-0056 502.533 µM 0.957587836272487 0.163665882577072 no 562 0.169135317588346 918 3758964
SGTC_2318 6029776 164 µM 0.955996642951041 0.164073991211691 no 563 0.169536965271119 837 818325
SGTC_2759 disulfiram 3.38 µM 0.955044624351072 0.164318479926254 no 564 0.169777565365359 799 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_85 0868-0259 160.055 µM 0.953632427288095 0.164681582311703 no 565 0.170134867743109 804 83173
SGTC_2814 7977482 42.97 µM 0.951749776652882 0.165166454985732 no 566 0.170611949207142 899 6456762
SGTC_2532 xanthone 78.9 µM 0.9463981965687 0.16654978416744 no 567 0.171972762448279 779 7020 An insecticide.
SGTC_3272 9137413 49.47 µM 0.946358974943929 0.166559950087103 no 568 0.171982761332412 825 17614870
SGTC_2228 7354201 200 µM 0.945570476450873 0.166764407312788 no 569 0.172183854300351 880 753451
SGTC_1506 4226-2149 212 µM 0.945342020739513 0.166823675995843 no 570 0.172242146021312 920 991114
SGTC_1979 st071809 45.3 µM 0.944093968198167 0.167147700412349 no 571 0.172560815696008 880 4976333
SGTC_1874 staurosporine 7.6 µM 0.943758162673819 0.167234952819804 no 572 0.17264662225542 892 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_84 0443-0269 128.823 µM 0.942468593946535 0.167570294484354 no 573 0.172976391502463 873 6150058
SGTC_722 3534-0461 190 µM 0.941281565807089 0.167879353905962 no 574 0.173280293486294 879 658262
SGTC_893 0958-0369 48.9 µM 0.939914622311777 0.168235711108113 no 575 0.173630678143504 887 6819948
SGTC_33 0986-0033 35.816 µM 0.938570247923275 0.168586658896645 no 576 0.173975717099686 828 2848082
SGTC_2262 9014885 67.46 µM 0.9372483530216 0.168932196974594 no 577 0.174315411383491 819 6457424
SGTC_2241 6772625 37.8075 µM 0.936474282681449 0.169134746943773 no 578 0.174514523814974 813 2285411
SGTC_727 3032-0951 202 µM 0.93527736501485 0.169448249676796 no 579 0.174822688582866 838 3652836
SGTC_2519 cryptotanshinone 88.04 µM 0.932628472495884 0.170143385906877 no 580 0.175505913639008 882 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2836 9010338 19.48 µM 0.932023347487591 0.170302442031474 no 581 0.175662229815037 817 2994051
SGTC_1138 3761-0006 1.03 µM 0.931356204323931 0.170477909886903 no 582 0.175834668755614 880 12061087
SGTC_1856 st057054 55.7 µM 0.928408208203626 0.171254659019308 no 583 0.176597931169734 920 1266018
SGTC_1940 st075990 51.1 µM 0.927083845357932 0.171604342578347 no 584 0.176941501509054 926 1084979
SGTC_3126 9127922 49.47 µM 0.924413673371977 0.172310758377454 no 585 0.177635489186924 864 45595682
SGTC_1346 1488-2224 62.4 µM 0.921321315721141 0.173131181830241 no 586 0.178441347771887 904 3722427
SGTC_2629 bisabolol 100 µM 0.917796653964245 0.17406932723915 no 587 0.179362667177065 901 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3009 9080819 71.4286 µM 0.91532772480762 0.174728393362593 no 588 0.180009804228742 892 17027216
SGTC_2027 5150920 200 µM 0.915118979672449 0.174784189187739 no 589 0.180064586062222 885 786715
SGTC_1728 st035614 33.7865 µM 0.915006446118891 0.174814273154875 no 590 0.180094123041508 941 15945546
SGTC_2981 9013952 38.96 µM 0.914467303424635 0.174958449543563 no 591 0.180235675441223 821 2996344
SGTC_1902 st060212 70.5 µM 0.913575179997849 0.175197184953441 no 592 0.18047005656864 933 688944
SGTC_2062 5245942 200 µM 0.91232783919865 0.175531323997811 no 593 0.180798081767154 981 1376160
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.911224442717375 0.175827239514934 no 594 0.181088563881093 768 88881 An O-methylated flavonoid and antioxidant.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.908551583323509 0.176545371929865 no 595 0.181793436729609 892 616764
SGTC_2965 9082772 38.63 µM 0.908301152835432 0.176612751435418 no 596 0.181859566803731 940 16459634
SGTC_2179 6298986 200 µM 0.907993877480812 0.176695447535208 no 597 0.181940728204782 869 738374
SGTC_120 rhodamine 6G 52.259 µM 0.907987074069817 0.176697278793903 no 598 0.181942525462869 1037 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2803 7707263 71.43 µM 0.906135663088264 0.177196064787286 no 599 0.18243202552965 849 2199229
SGTC_733 4069-0007 56.1 µM 0.905026543934487 0.177495296517908 no 600 0.1827256625307 938 5717425 YNL287W SEC21
SGTC_635 k038-0028 24.7 µM 0.903341561435323 0.177950501666331 no 601 0.183172322451344 911 4035102
SGTC_1773 st048542 73.5835 µM 0.901727913842299 0.178387124837082 no 602 0.183600710504685 877 3237138
SGTC_2504 purpurogallin 52.29 µM 0.90137144738568 0.178483669007737 no 603 0.183695428660122 868 5281571 An antioxidant.
SGTC_3050 9093513 49.47 µM 0.901367018633964 0.178484868682848 no 604 0.183696605633235 930 25236664
SGTC_1964 st076914 61 µM 0.900738196245872 0.178655257757915 no 605 0.183863767467054 948 24208661
SGTC_1604 st002052 72.4 µM 0.90003818351366 0.178845057381233 no 606 0.184049965451562 897 6254834 YHR062C RPP1
SGTC_286 k060-0067 22.9 µM 0.899859362139711 0.178893562886191 no 607 0.184097549375242 886 5985051
SGTC_2603 homopterocarpin 100 µM 0.898081119583375 0.179376363701028 no 608 0.184571151950983 896 101795 A weak amylase inhibitor.
SGTC_809 3998-0021 90 µM 0.896122034990413 0.1799092114275 no 609 0.185093794837938 910 715485
SGTC_1127 asiatic acid 681.4 nM 0.895760369760679 0.180007688661374 no 610 0.18519038000225 857 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1436 4092-1007 8.32 µM 0.893510167315558 0.180621152763804 no 611 0.185792014888209 914 2881121
SGTC_263 alizarin 107.927 µM 0.893428083460361 0.180643555728925 no 612 0.185813984479361 970 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2424 5537928 59.2 µM 0.892007748092848 0.181031480612179 no 613 0.186194389720357 937 5382802
SGTC_3128 9127691 49.47 µM 0.89157043426592 0.181151025670702 no 614 0.186311611612224 811 41316314
SGTC_3149 9097855 49.47 µM 0.889546624062638 0.181704902548309 no 615 0.186854688787535 895 25236625 YMR079W SEC14
SGTC_2513 baicalein 25.65 µM 0.888915307723044 0.181877897950425 no 616 0.187024298955717 910 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_4 0960-0234 25.671 µM 0.888705331513216 0.181935459150815 no 617 0.18708073250415 885 6821112
SGTC_3334 9142812 21.919 µM 0.888680024581989 0.181942397359913 no 618 0.187087534747407 881 45283678
SGTC_936 3005-4620 401 µM 0.886973171897569 0.182410734074058 no 619 0.187546672291279 969 777207
SGTC_671 0560-0003 407 µM 0.886299051796583 0.182595910566991 no 620 0.187728199935477 899 3238678
SGTC_3155 9099265 49.47 µM 0.88599119973669 0.182680514597783 no 621 0.187811134690661 851 25236499
SGTC_2614 arthonioic acid 13.39 µM 0.88489775296685 0.182981213906999 no 622 0.188105890030547 887 6710684
SGTC_2860 9025725 38.96 µM 0.884317678950329 0.183140860338996 no 623 0.188262373717569 863 40546248
SGTC_1923 st058458 19.1 µM 0.88336400365541 0.183403517098779 no 624 0.18851981647494 993 3534982
SGTC_2012 4023501 200 µM 0.881372206599608 0.183952845440394 no 625 0.189058197883623 856 3477460
SGTC_1117 retinoic acid 1.10837 µM 0.880881210875237 0.184088417022449 no 626 0.18919105905328 983 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3232 9132874 49.47 µM 0.880454201654225 0.184206371487356 no 627 0.189306652500367 914 3784940
SGTC_2756 carbadox 75.1 µM 0.880401382368666 0.18422096523821 no 628 0.189320953955636 893 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_867 0518-0118 155 µM 0.878598363652175 0.184719563314575 no 629 0.189809541676236 979 6848158
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.878083280612809 0.184862155813032 no 630 0.189949262776336 971 6708739 YPR165W RHO1
SGTC_3033 9090887 49.47 µM 0.877354385110389 0.185064055734942 no 631 0.19014709051889 957 19325384
SGTC_2973 9094665 17.96 µM 0.876179679231439 0.185389730759859 no 632 0.190466180877531 976 25237061 YIL048W NEO1
SGTC_3069 9117009 49.47 µM 0.87448398374692 0.185860471788322 no 633 0.190927369344811 823 41904981
SGTC_1343 1487-0095 224 µM 0.872663266309609 0.186366744580771 no 634 0.191423322706586 950 4560101 YGL055W OLE1
SGTC_1047 2043-3044 82 µM 0.868951535357618 0.187401479802515 no 635 0.192436819877062 987 669592
SGTC_1275 0867-0008 21.1 µM 0.868934081749482 0.187406353793371 no 636 0.192441593364046 951 3422836
SGTC_1882 5615643 20 µM 0.867547212228721 0.187793893181033 no 637 0.192821127627835 914 2253075
SGTC_185 k048-0037 25.491 µM 0.867272377171901 0.187870750336205 no 638 0.192896393944613 987 6827589
SGTC_2208 7283366 200 µM 0.864711994264094 0.188587690077616 no 639 0.193598442286878 965 898663
SGTC_1685 st024049 53.0905 µM 0.858118235538477 0.190441778020847 no 640 0.195413589463317 941 1941139
SGTC_1899 st063254 59.6 µM 0.856752374163667 0.190827237183258 no 641 0.195790875775367 874 3093813
SGTC_3001 9076041 71.4286 µM 0.856629897336773 0.190861824688024 no 642 0.195824728634462 940 16004211
SGTC_92 0063-0024 660.874 µM 0.855521220630958 0.191175090390982 no 643 0.196131330851657 1054 3594437
SGTC_3348 9149464 3.537 µM 0.855298534782036 0.191238050102335 no 644 0.196192949247873 987 1951442
SGTC_1721 st082152 9.2685 µM 0.854642514052697 0.191423599946334 no 645 0.196374541999461 937 5296051
SGTC_2052 5265182 7.135 µM 0.853840258606261 0.191650660914076 no 646 0.196596752327157 972 1239884
SGTC_2067 5224629 34.075 µM 0.853681425901663 0.191695634613526 no 647 0.196640764187665 955 2835000
SGTC_1188 1403-0014 4.57 µM 0.852525544196803 0.192023118739106 no 648 0.196961233776779 1005 9614867
SGTC_2302 7771753 200 µM 0.8524261851656 0.192051285086826 no 649 0.196988795935869 971 2203047
SGTC_2772 vinpocetine 57.06 µM 0.851837676175924 0.19221816773842 no 650 0.197152095976921 932 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2859 9028643 45.46 µM 0.851719585133049 0.192251665328973 no 651 0.197184873857837 932 17151580
SGTC_1284 0929-0043 16 µM 0.847354469167436 0.193492374009558 no 652 0.198398787337997 967 1239883
SGTC_2571 chrysanthemic acid 100 µM 0.847064740770877 0.193574896782424 no 653 0.198479518393594 911 2743 An insecticide.
SGTC_3289 9119912 71.43 µM 0.846454296884232 0.193748838565446 no 654 0.198649679725221 957 17014829
SGTC_2321 7390090 138.78 µM 0.844889508351984 0.194195149286683 no 655 0.199086266400768 902 649046
SGTC_18 0111-0177 500 nM 0.844345059999083 0.194350584170485 no 656 0.199238306663236 1067 721752
SGTC_1611 st001856 99.4 µM 0.843265380580397 0.194659046455012 no 657 0.199540019975515 938 647478
SGTC_598 3937-0236 20.2 µM 0.842233590372376 0.194954105064543 no 658 0.199828607594419 1029 1379313
SGTC_2331 7980721 200 µM 0.842184752806729 0.194968077765073 no 659 0.199842273486877 987 2981221
SGTC_1917 st066507 28.5 µM 0.841136292694055 0.195268194898697 no 660 0.200135792683501 980 3156428
SGTC_1243 0416-0003 5.65 µM 0.838407064634647 0.196050739876719 no 661 0.200901061545164 965 2141977
SGTC_288 1315-0019 35.1 µM 0.83735326545454 0.19635340150711 no 662 0.201197013476576 1003 6811474
SGTC_2161 5662504 8.5105 µM 0.835516659723499 0.196881569473108 no 663 0.201713435412641 938 2859334
SGTC_3090 9117696 49.47 µM 0.834794208327936 0.197089566328656 no 664 0.201916793683769 963 7923821
SGTC_166 k072-0058 166.424 µM 0.833960629193931 0.197329722501106 no 665 0.202151585036498 1061 5846229
SGTC_276 colchicine 750 µM 0.833916656034476 0.197342396187975 no 666 0.202163975338529 1011 2833 A microtubule depolymerizer.
SGTC_836 0330-0104 1.35 µM 0.833696303817774 0.197405912229696 no 667 0.202226070749844 1005 46494820
SGTC_1314 1222-0010 41.1 µM 0.833675831753263 0.197411813884835 no 668 0.202231840371382 987 3526027
SGTC_2738 aclarubicin 5.55 µM 0.828058545128042 0.199035185172751 no 669 0.203818672501259 909 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2182 6325192 200 µM 0.827082975719638 0.19931793803019 no 670 0.204095016394935 959 736248
SGTC_2420 aureobasidin a 50 nM 0.825454974223547 0.199790325936575 no 671 0.20455666762273 1020 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1474 0330-0125 5.35 µM 0.825359612000031 0.199818017512422 no 672 0.204583728671712 1041 X1474
SGTC_250 brefeldin a 552.239 µM 0.82488355127287 0.199956292016478 no 673 0.204718852833905 902 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3105 9121040 49.47 µM 0.824615115262319 0.200034286120722 no 674 0.204795068596389 809 41448907
SGTC_2520 obtusaquinone 4.71 µM 0.824517882197902 0.200062541706976 no 675 0.2048226796817 1024 5967872
SGTC_41 0478-0632 82.643 µM 0.824209871579572 0.20015206434568 no 676 0.204910159474061 1061 3750424
SGTC_2365 9042475 200 µM 0.823083021249086 0.200479786138378 no 677 0.205230391693123 1019 6464479
SGTC_564 3555-0129 330 µM 0.822980395799106 0.200509648693275 no 678 0.205259570913427 922 563260
SGTC_2870 9038528 12.99 µM 0.82297247022284 0.20051195503502 no 679 0.205261824473891 926 6463316
SGTC_1896 st058441 89 µM 0.822524099576279 0.200642456782853 no 680 0.205389338238995 914 688759
SGTC_1557 sumaresinolic acid 42.3 µM 0.820439696620963 0.201249807645215 no 681 0.205982746657313 973 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_834 0312-0008 75.7 µM 0.818893439647994 0.201701065475637 no 682 0.206423606596128 1008 6385573 YIL048W NEO1
SGTC_1105 epirubicin 18.1 µM 0.818554386225467 0.201800095382644 no 683 0.206520350248959 992 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_664 1222-0054 14.9 µM 0.816121371610484 0.202511578100183 no 684 0.207215360872075 1031 6813991
SGTC_2853 9015042 58.44 µM 0.815932305357225 0.202566929178198 no 685 0.207269427063644 1001 6457456
SGTC_1423 4048-0112 5.59 µM 0.815052266496303 0.202824688538421 no 686 0.207521196488623 1041 X1423
SGTC_1665 st014639 11.4 µM 0.813454523417034 0.203293160686868 no 687 0.207978754863678 1076 981133 YIL048W NEO1
SGTC_508 roscovitine 141 µM 0.812493324905884 0.203575303265021 no 688 0.208254307621297 1045 160355 A CDKinase inhibitor.
SGTC_670 4204-0025 119 µM 0.811056747210854 0.203997419940485 no 689 0.208666541578796 1053 719039
SGTC_2165 5727197 32.143 µM 0.810788394018656 0.204076329243136 no 690 0.208743600300613 996 1361712
SGTC_1824 st053723 68.6 µM 0.808958657555207 0.204614848047457 no 691 0.209269463489287 1054 675225
SGTC_1291 0993-0025 5.79 µM 0.808640764564225 0.20470849484066 no 692 0.209360904840721 1036 4353356
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.80851516944372 0.20474550041742 no 693 0.209397038531981 1045 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3318 9139014 38.6185 µM 0.808367321028332 0.204789067844314 no 694 0.209439579193983 994 16643984
SGTC_2445 5742597 35.57 µM 0.807625797385356 0.205007660460866 no 695 0.209653015677092 985 1774255
SGTC_2903 5923464 63.88 µM 0.805746056411536 0.20556240749408 no 696 0.210194643769474 1064 2876576
SGTC_658 3253-0951 102 µM 0.802524249372009 0.206515293652609 no 697 0.2111248834886 1081 1184878
SGTC_3219 9131112 49.47 µM 0.799974378622634 0.20727129861337 no 698 0.211862820956057 998 17612988 YMR079W SEC14
SGTC_2489 cantharidin 73.42 µM 0.799585661310064 0.207386692053323 no 699 0.211975448893915 1045 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1642 st009582 77.7 µM 0.798646103980881 0.207665762980551 no 700 0.212247823186076 1035 6739311
SGTC_2776 terbinafine 19.92 µM 0.797511270754383 0.208003131162286 no 701 0.212577079867676 1073 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3320 9137005 35.139 µM 0.796974555779602 0.208162800769009 no 702 0.212732904389096 977 4908713
SGTC_226 1,3-diallylurea 8.28947 mM 0.79497135471319 0.208759379957961 no 703 0.213315082623801 1018 74537 YKL182W FAS1
SGTC_1205 4161-2785 76 µM 0.794851928529155 0.208794978416795 no 704 0.213349820050373 932 3498106
SGTC_1209 2323-2347 50.3 µM 0.794397988810509 0.208930321029375 no 705 0.213481887326724 1067 5412760
SGTC_2237 6667747 47.222 µM 0.794306489322716 0.208957607956495 no 706 0.213508513564207 973 729940 YDL015C TSC13
SGTC_1752 st044819 83.042 µM 0.793501627576391 0.209197723816656 no 707 0.21374281070653 1029 441209 YML126C ERG13
SGTC_2711 st079103 59.1 µM 0.793412520851918 0.209224317170405 no 708 0.213768759087182 1039 54693780
SGTC_1614 st002383 48.6 µM 0.793144973275067 0.209304177055876 no 709 0.21384668147383 1077 1947235
SGTC_1980 st071811 45.7 µM 0.788722333252836 0.210626881819869 no 710 0.215137155931751 1050 4974850
SGTC_3296 9122258 64.045 µM 0.788293613606946 0.210755361744762 no 711 0.215262491194771 1045 4730474
SGTC_2991 9074669 71.4286 µM 0.787729401289614 0.210924516538536 no 712 0.215427502010836 1066 17333109
SGTC_2655 perillic acid 100 µM 0.784719999950584 0.21182809977334 no 713 0.21630887695972 1053 5702197 An apoptosis inducer.
SGTC_2034 5197015 53.07 µM 0.78150893096366 0.212794727460208 no 714 0.217251613016478 1045 780676
SGTC_348 k064-0012 10.7 µM 0.78143580115379 0.212816771664469 no 715 0.217273110760848 1023 5066323
SGTC_47 0149-0135 24.25 µM 0.780436828133734 0.213118034920263 no 716 0.217566898772408 1056 5239155
SGTC_976 1348-1067 47.6 µM 0.778075601423646 0.213831105157072 no 717 0.21826222269093 1151 5310671 YGL099W LSG1
SGTC_2597 laccaic acid a 100 µM 0.775881251971469 0.214495023711507 no 718 0.218909551618375 1034 5491415 A textile dye.
SGTC_2887 9044784 58.44 µM 0.774149497713321 0.215019825376758 no 719 0.219421194659731 1136 6465546
SGTC_1571 st070080 73.4 µM 0.772699974458724 0.215459670663312 no 720 0.219849980896366 1077 4315245
SGTC_951 1171-0579 82.7 µM 0.771038123260339 0.215964586643428 no 721 0.220342167512537 1120 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_788 1182-0090 188 µM 0.770857667672777 0.216019455232035 no 722 0.22039565061877 1146 5715185
SGTC_3220 9131269 49.47 µM 0.770033812804048 0.2162700557461 no 723 0.220639917772871 1104 17722206
SGTC_1702 st027038 51 µM 0.769613466518479 0.21639798167002 no 724 0.220764607205498 1096 5521182
SGTC_493 zm226600 134 µM 0.766641136214707 0.217303813542331 no 725 0.221647455234791 1105 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1765 st044815 90.4 µM 0.766581165536496 0.217322112401245 no 726 0.221665288595221 1081 645695
SGTC_1758 st042942 75.2445 µM 0.765915879023995 0.217525171022823 no 727 0.221863178502848 1088 669317
SGTC_1951 sophoraflavanone G 9.2 µM 0.765632854555524 0.217611588889859 no 728 0.221947394898915 1119 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1031 k035-0009 16 µM 0.765007564729532 0.217802583286364 no 729 0.222133520033155 1140 5180959
SGTC_1234 0326-0494 15.5 µM 0.764504565044746 0.217956294385179 no 730 0.222283308651091 1096 1547813
SGTC_738 1315-0003 72.4 µM 0.762800884288191 0.218477384714578 no 731 0.222791076836166 1101 6251474
SGTC_495 decylubiquinone 155 µM 0.762537197302552 0.218558100472964 no 732 0.222869725620437 1073 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2045 5106652 78.05 µM 0.761870422735867 0.218762279712777 no 733 0.223068672159923 1096 673349
SGTC_492 tmb-8 126 µM 0.761328290126143 0.21892837205792 no 734 0.2232305036017 975 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2157 5649910 96.377 µM 0.760222208197102 0.219267465582134 no 735 0.223560886147141 1086 2858091
SGTC_2714 st079313 56.9 µM 0.75914614519834 0.219597645658969 no 736 0.223882568864604 1072 2939799
SGTC_2214 7179297 48.276 µM 0.758110581475183 0.219915668358827 no 737 0.224192392794634 1094 769744
SGTC_851 0394-0702 453 µM 0.753810199937897 0.221239144289478 no 738 0.225481599186299 1137 762646
SGTC_2832 7992762 51.95 µM 0.75304575356195 0.221474884629239 no 739 0.225711210164659 1006 2985177
SGTC_15 0266-0086 27.098 µM 0.751809147483966 0.221856533675576 no 740 0.226082920089139 1207 1712902 YIL048W NEO1
SGTC_2313 7726885 200 µM 0.751585916096148 0.221925468734463 no 741 0.226150057788407 1093 726423
SGTC_3285 9112818 20.8695 µM 0.751413384037584 0.221978755945526 no 742 0.226201955187245 1167 17017947 YPR165W RHO1
SGTC_383 2324-0395 7.37 µM 0.75102441302012 0.222098917985553 no 743 0.2263189818017 1110 3146421
SGTC_3270 9137563 49.47 µM 0.750872794255209 0.222145766543489 no 744 0.226364607394668 1054 17015724
SGTC_1090 efavirenz 20.7 µM 0.749382454889364 0.222606565370523 no 745 0.226813361386436 1102 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2890 9046729 58.44 µM 0.749294075079084 0.222633908676182 no 746 0.226839989061797 1039 903329
SGTC_3228 9131799 49.47 µM 0.749059931630531 0.222706358184435 no 747 0.226910541929844 1052 17015818
SGTC_135 0933-0004 26.348 µM 0.748135166611218 0.222992633611006 no 748 0.227189316086013 1054 21230617 YGL099W LSG1
SGTC_262 fenpropimorph 62.5 µM 0.745632431554417 0.22376844452124 no 749 0.227944743033138 1041 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2112 5488546 200 µM 0.742273766115251 0.224811988383744 no 750 0.2289607415147 1125 600757
SGTC_1739 st037196 92.5 µM 0.73874088743751 0.22591263223777 no 751 0.230032176341128 1155 612214
SGTC_3216 9129716 49.47 µM 0.73831623612776 0.226045134230226 no 752 0.230161151217633 1098 8056934
SGTC_881 0833-0569 170 µM 0.736680892767793 0.226555813006387 no 753 0.23065821453498 1114 5418700
SGTC_148 3253-0744 288.01 µM 0.736493950739241 0.226614232002416 no 754 0.23071507381889 1140 6893655
SGTC_1591 genipin 88.4 µM 0.735981172829359 0.22677451767564 no 755 0.230871077782599 1084 442424 A DNA cross-linking agent.
SGTC_513 4245-1575 41.7 µM 0.73584553070291 0.226816927798419 no 756 0.230912354443549 1157 719745
SGTC_2360 9040895 200 µM 0.735831583366522 0.226821288852574 no 757 0.230916598929961 1088 4914414
SGTC_414 piperonyl butoxide 100 µM 0.735229944260629 0.227009454437801 no 758 0.231099732628883 1146 5794 A potent inhibitor of cytochrome P450.
SGTC_1750 st081859 2.357 µM 0.734050875028788 0.22737846929006 no 759 0.231458865988232 1176 5291695
SGTC_1729 st035615 45.989 µM 0.732769627582317 0.227779845845973 no 760 0.231849474412889 1069 17385451
SGTC_822 1487-0950 154 µM 0.732170631505222 0.227967630127552 no 761 0.232032213661092 1138 1958375
SGTC_552 k242-0005 476 µM 0.732054727259368 0.228003975970503 no 762 0.232067582506602 1146 4088318
SGTC_1426 4048-4480 71.7 µM 0.731417594593572 0.228203829467211 no 763 0.232262060780555 1134 14224343
SGTC_374 0880-0231 82.3 µM 0.729094402608596 0.228933393675031 no 764 0.232971959154656 1128 6833587
SGTC_45 0kpi-0036 14.9 µM 0.726890238338182 0.22962678730193 no 765 0.233646598781848 1130 2795021
SGTC_611 3453-1652 23.7 µM 0.726290919300401 0.229815526386764 no 766 0.233830222489918 1163 1560575
SGTC_708 3448-5400 146 µM 0.725114015643354 0.230186412535561 no 767 0.234191043368169 1156 3462195
SGTC_995 3931-2021 34.6 µM 0.724086187453628 0.230510593157314 no 768 0.234506411961951 1119 730143
SGTC_567 1080-0542 68.4 µM 0.723762435368467 0.230612758525037 no 769 0.234605797470525 1098 5950415
SGTC_2766 oltipraz 83.91 µM 0.719769204790625 0.231874967608731 no 770 0.235833554278393 1124 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_925 2064-1272 59.6 µM 0.719001366308333 0.232118111841107 no 771 0.236070038919161 1108 6815817
SGTC_1667 st014849 34.6 µM 0.717900838757453 0.232466852950543 no 772 0.236409215339008 1196 5348460
SGTC_1192 1488-0095 21.4 µM 0.717285100087535 0.232662098593618 no 773 0.236599099510137 1140 915875
SGTC_960 1222-0186 7.7 µM 0.716903959018624 0.23278300093499 no 774 0.236716679486025 1148 3126296
SGTC_2770 toltrazuril 17.5 µM 0.716614872639307 0.232874725744128 no 775 0.236805882512565 1159 68591 Kills coccidiodes.
SGTC_563 tetrahydrosecaminediol 614 µM 0.71562051742131 0.233190380006569 no 776 0.237112850563988 1209 334274 A psychoactive constituent of the cannabis plant.
SGTC_1762 st045503 25.4615 µM 0.71560167325998 0.233196364305759 no 777 0.237118670067606 1203 4645554
SGTC_3197 9113331 49.47 µM 0.714899273701665 0.233419484597933 no 778 0.23733564292191 1174 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2639 lactacystin 53 µM 0.714090419493886 0.233676567323526 no 779 0.237585634867195 1177 3870 A proteasome inhibitor.
SGTC_1002 4049-0206 172 µM 0.713982527432531 0.233710871131808 no 780 0.237618991903017 1202 4662749
SGTC_1242 0402-0103 60.1 µM 0.712521567561391 0.234175651649311 no 781 0.238070930410932 1147 432868
SGTC_419 nsc-638432 893 µM 0.712072451325024 0.23431863341938 no 782 0.238209956232199 1136 368090
SGTC_1776 st049249 45.9 µM 0.71196667298693 0.234352316305044 no 783 0.238242706832531 1188 1822314
SGTC_1349 flufenamic acid 69 µM 0.711718032073172 0.234431501322427 no 784 0.238319699596291 1144 3371 A non-steroidal anti-inflammatory.
SGTC_688 0527-0193 473 µM 0.71103949388959 0.234647671628872 no 785 0.238529881284638 1150 4007154
SGTC_3297 9117502 71.43 µM 0.710977793943346 0.234667333610223 no 786 0.238548998282515 1175 7453720
SGTC_2521 angolensin 13.4 µM 0.705925550254423 0.236280424927421 no 787 0.240117218709763 1196 821428 A flavenoid.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.705881613321154 0.236294479936073 no 788 0.240130881373041 1126 6857784
SGTC_969 1313-0238 134 µM 0.704535105269529 0.23672543826908 no 789 0.240549797994385 1202 5212874
SGTC_346 4513-0042 7.16 µM 0.704171058352944 0.236842027960158 no 790 0.240663126143311 1172 2827372
SGTC_336 4111-0029 111 µM 0.703432172350976 0.237078760685749 no 791 0.24089323137828 1138 3131175
SGTC_2455 5377712 9.75 µM 0.702460541588968 0.237390260644463 no 792 0.241196000492062 1144 2243908
SGTC_2463 5473429 200 µM 0.702136019799551 0.23749435074551 no 793 0.241297170536413 1135 5399405
SGTC_2752 diclazuril 33.15 µM 0.701467464513905 0.237708868258385 no 794 0.241505666088659 1252 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1461 k072-0203 53.8 µM 0.695431522927476 0.239650408302885 no 795 0.243392455584067 1153 5418714
SGTC_565 1418-0001 44.5 µM 0.694541868051778 0.239937307576678 no 796 0.243671226903939 1219 2862145
SGTC_2460 5552655 174.22 µM 0.694459007918403 0.239964038158452 no 797 0.243697199710359 1195 5401989
SGTC_298 1391-0729 10 µM 0.694078333394849 0.240086864179008 no 798 0.243816542711701 1168 3237558
SGTC_532 1548-0774 215 µM 0.69193795275435 0.240778103458012 no 799 0.244488147588065 1279 5932993
SGTC_2939 9044578 71.43 µM 0.690955287955797 0.241095818947893 no 800 0.244796819918506 1188 2653634
SGTC_1615 st002656 86.5 µM 0.689490818415559 0.241569734359628 no 801 0.245257224604891 1206 1584458
SGTC_2065 5221596 34.26 µM 0.688571112833533 0.241867617683795 no 802 0.245546602437 1190 788581
SGTC_3346 9158254 43.5805 µM 0.687871323293272 0.242094405873618 no 803 0.245766908299882 1170 17639500
SGTC_1742 st038235 28.8875 µM 0.686793053510654 0.242444077750582 no 804 0.246106573917117 1184 564103 YBR002C RER2
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.685679271560821 0.242805552932862 no 805 0.246457690414282 1194 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1115 galangin 695.678 nM 0.684002090647376 0.243350427710961 no 806 0.246986922817286 1258 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3198 9112019 49.47 µM 0.682359371440135 0.243884746623525 no 807 0.247505869762108 1250 45595555
SGTC_218 alverine citrate 93.75 µM 0.68197538343501 0.244009735672012 no 808 0.247627258318865 1219 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.681969473503939 0.244011659639208 no 809 0.247629126849637 1227 91467 include heat shock
SGTC_2116 5511452 16.8835 µM 0.681906568377824 0.244032138794478 no 810 0.247649015900872 1209 870744
SGTC_899 1083-0020 478 µM 0.681413816669308 0.244192589249582 no 811 0.247804841365697 1248 767123
SGTC_2875 9039966 71.43 µM 0.68070303864762 0.24442413388168 no 812 0.24802970661703 1254 6463691
SGTC_1522 st012842 45.6 µM 0.678486952131819 0.245146809956479 no 813 0.248731497004666 1151 3491067 YOR116C RPO31
SGTC_96 0929-0093 37.281 µM 0.678386346841042 0.245179645052222 no 814 0.248763381765263 1191 6991579
SGTC_2184 6075246 200 µM 0.677137343654684 0.24558748587194 no 815 0.249159408584167 1240 2267320
SGTC_2483 5729050 27.16 µM 0.676734146621122 0.245719220790221 no 816 0.249287323563734 1263 2865180
SGTC_1494 4358-1428 177 µM 0.674100376302488 0.246580674425039 no 817 0.250123750147731 1263 1564571
SGTC_2545 solidagenone 89.61 µM 0.673946718394343 0.246630982753512 no 818 0.250172594382423 1076 6708572 An anti ulcer agent
SGTC_17 0960-0276 49.807 µM 0.673866564524761 0.246657227692489 no 819 0.250198075419795 1239 6821114
SGTC_3143 9086658 49.47 µM 0.673759927990826 0.246692146220791 no 820 0.250231977470116 1282 25236626
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.672262186535592 0.247182866785354 no 821 0.250708399000291 1248 229346 A bile salt which induces apoptosis.
SGTC_1941 st076221 61.8 µM 0.672146471255929 0.247220801494379 no 822 0.25074522723597 1230 2828568
SGTC_3194 9111903 49.47 µM 0.671838829560401 0.247321670195347 no 823 0.250843153049099 1249 17087251
SGTC_2040 5100729 123 µM 0.67155636384516 0.247414303636613 no 824 0.250933082889526 1239 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1692 fluoroquinolonic acid 71 µM 0.671109107750882 0.247561017305538 no 825 0.251075512652893 1243 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2411 st077133 39.94 µM 0.670289191024652 0.247830095706724 no 826 0.251336728106258 1332 1403142 YNL221C POP1
SGTC_408 cantharidin 100 µM 0.669616880874971 0.248050849361753 no 827 0.251551025060018 1212 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2246 7293507 91.5585 µM 0.669220747654329 0.248180969168363 no 828 0.251677336582871 1264 887656
SGTC_3073 9114972 49.47 µM 0.668951402706103 0.248269463000191 no 829 0.251763239369654 1173 41905075
SGTC_2469 5655019 90.81 µM 0.667116634813294 0.24887272711696 no 830 0.252348817682316 1284 2788239
SGTC_1229 0139-0193 12.2 µM 0.665362679355303 0.249450149105667 no 831 0.252909274688425 1279 3090752
SGTC_2363 9053361 176 µM 0.664612775712852 0.249697242975209 no 832 0.253149097852735 1287 6469797 YMR079W SEC14
SGTC_1216 1165-0504 9.65 µM 0.663311498168163 0.250126323294587 no 833 0.253565537003892 1240 6304004
SGTC_2889 9059656 51.95 µM 0.662782850611926 0.250300750000918 no 834 0.253734819288914 1302 3949838
SGTC_1428 4049-0204 61.7 µM 0.662767848934379 0.250305700729511 no 835 0.253739623956773 1290 X1428
SGTC_1472 k841-0093 193 µM 0.65879020809848 0.251620198335339 no 836 0.255015248022129 1305 X1472
SGTC_2473 5854593 8.94 µM 0.658283888712119 0.251787783784557 no 837 0.255177864349627 1216 2872951
SGTC_355 1311-2252 105 µM 0.657810525392485 0.251944514469879 no 838 0.255329945096528 1222 5338538
SGTC_763 3453-1109 128 µM 0.657759578263533 0.251961386142405 no 839 0.255346316060683 1268 1560353
SGTC_2620 irigenin 100 µM 0.657122381155405 0.252172450955045 no 840 0.255551114480195 1292 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3277 9138724 49.47 µM 0.656463211264108 0.252390892108964 no 841 0.255763065322289 1202 15943418
SGTC_903 1134-0042 114 µM 0.655388828997984 0.252747143409074 no 842 0.256108720992478 1250 701009
SGTC_1420 4'-methoxyflavone 42 µM 0.654806351146076 0.252940396181039 no 843 0.256296220495472 1253 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_128 0906-2981 13.371 µM 0.654105314359017 0.253173087159454 no 844 0.256521978940466 1260 6740226
SGTC_1834 st055981 52.8 µM 0.651761125448005 0.253951996760559 no 845 0.257277641692532 1315 471719 YDL150W RPC53
SGTC_452 diindolylmethane 8 µM 0.65142192454088 0.254064807962738 no 846 0.257387080798483 1250 3071 Inhibits expression of several cancer promoting factors.
SGTC_2828 7998861 71.43 µM 0.651186233342435 0.254143209454728 no 847 0.257463137978869 1198 2988188
SGTC_578 3460-0051 92 µM 0.650972469963834 0.25421432773935 no 848 0.257532129181642 1322 2876744
SGTC_568 1193-0097 7.48 µM 0.650533017989191 0.254360564556556 no 849 0.25767399055456 1179 3646150
SGTC_3327 9140648 26.9345 µM 0.649803142043593 0.254603543409424 no 850 0.257909694552081 1253 8029710
SGTC_462 ag-879 158 µM 0.647043457790637 0.255523351917537 no 851 0.258801908937425 1271 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2291 7917025 104.35 µM 0.646078743976185 0.255845302052583 no 852 0.25911418022069 1235 2964612
SGTC_3002 9075603 71.4286 µM 0.645147271179754 0.256156359577208 no 853 0.259415876361169 1257 20105405
SGTC_2000 st075254 36.4 µM 0.644973167094135 0.256214522043494 no 854 0.259472287319511 1258 17234175
SGTC_2257 7960413 200 µM 0.644484772582663 0.256377715376964 no 855 0.259630564411396 1259 2974689 YIL048W NEO1
SGTC_1308 1187-1617 41.4 µM 0.643971891107496 0.256549149136956 no 856 0.259796830785332 1271 2882570
SGTC_705 1124-0212 310 µM 0.642701016976689 0.256974203711264 no 857 0.26020906050479 1274 9554485
SGTC_990 3985-0011 41.3 µM 0.642251646521434 0.257124587079488 no 858 0.260354902113122 1270 5399565 YGL099W LSG1
SGTC_965 1291-5240 308 µM 0.642110932635725 0.257171686872356 no 859 0.260400578967982 1291 2834598
SGTC_1131 3454-3128 32.3 µM 0.640125316196192 0.257836790943932 no 860 0.261045565760008 1369 710982
SGTC_1908 st060353 56.5 µM 0.63990790821524 0.257909668319958 no 861 0.261116236139076 1322 4227716
SGTC_726 3448-4391 34.2 µM 0.639308621571741 0.258110610643293 no 862 0.261311090441468 1369 1356692
SGTC_2686 alizarin 95.37 µM 0.638474512081765 0.258390424725558 no 863 0.261582420201883 1251 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_141 0443-0274 32.331 µM 0.638411385240352 0.25841160793231 no 864 0.261602960789765 1357 1627241
SGTC_525 k781-2675 26.7 µM 0.637372243936132 0.25876043743595 no 865 0.261941201715169 1324 3651118 YDL195W SEC31
SGTC_1027 k015-0025 8.67 µM 0.636909716381603 0.258915781724095 no 866 0.262091826711478 1260 3598955
SGTC_2405 ticlatone 3.52 µM 0.635970906337535 0.259231238304373 no 867 0.262397692520371 1187 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_105 0111-0055 734.78 µM 0.635953543500508 0.259237074391368 no 868 0.262403351081318 1261 5179370
SGTC_612 0302-0167 22.4 µM 0.635561974653999 0.259368708578403 no 869 0.262530980238835 1325 235821
SGTC_1022 4477-0945 21.3 µM 0.633616643404077 0.260023184566515 no 870 0.263165518208379 1279 4648966
SGTC_2727 riluzole 51.77 µM 0.633360601122973 0.260109389324113 no 871 0.263249093685342 1285 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2486 5283202 22.39 µM 0.632104167253166 0.260532621083647 no 872 0.263659406166049 1260 1377751
SGTC_3065 9113888 49.47 µM 0.631509042352602 0.260733213536021 no 873 0.26385386937059 1358 16648368
SGTC_2769 toremifene 3.73 µM 0.630927797801448 0.260929204171163 no 874 0.264043867588729 1312 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2035 5154463 94.595 µM 0.630137540830388 0.261195793465667 no 875 0.264302299923844 1305 2769623
SGTC_3183 9108214 49.47 µM 0.629910824859671 0.261272300810045 no 876 0.264376465064236 1224 4974831
SGTC_1972 st070201 17.4 µM 0.629869083159567 0.261286388177267 no 877 0.264390121097499 1300 2829099
SGTC_1055 3448-0672 86 µM 0.629677365328845 0.261351095859794 no 878 0.26445284728151 1291 748378
SGTC_1886 st057356 49.9 µM 0.629112090405774 0.26154193264124 no 879 0.264637837841987 1243 24207747
SGTC_2595 hexamethylquercetagetin 100 µM 0.62906046017851 0.261559366567533 no 880 0.264654737510321 1267 386331
SGTC_3058 9093861 49.47 µM 0.62824893884188 0.261833470506859 no 881 0.264920437752443 1317 17217477
SGTC_2194 5927483 104.545 µM 0.626707874591578 0.262354394139956 no 882 0.265425370556782 1314 760979
SGTC_2844 9010103 25.97 µM 0.625850018703406 0.262644603664505 no 883 0.265706660204017 1310 2480525
SGTC_402 epigallocatechin gallate 10 µM 0.625035976395981 0.262920143024371 no 884 0.265973723132483 1283 65064 An antioxidant.
SGTC_3245 9134821 49.47 µM 0.624759570411251 0.26301373530834 no 885 0.266064434583012 1253 17014901
SGTC_1278 0874-0585 172 µM 0.624731496916329 0.263023242069882 no 886 0.266073648673303 1290 766306
SGTC_2999 9069765 71.4286 µM 0.62356632326075 0.263417969389443 no 887 0.266456216482598 1323 2097066
SGTC_2434 5670830 169.91 µM 0.6229183896492 0.263637601425901 no 888 0.26666907637741 1300 1549830
SGTC_502 l-744,832 89.3 µM 0.622366025047723 0.26382491188561 no 889 0.266850607686007 1269 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2167 5876490 200 µM 0.622355278328676 0.263828556841358 no 890 0.266854140149778 1430 686534
SGTC_781 4335-2806 94.4 µM 0.621453386292121 0.264134542281346 no 891 0.267150677673575 1418 845254
SGTC_22 0964-0034 14.468 µM 0.621221784509473 0.264213147116007 no 892 0.26722685399795 1275 138402
SGTC_602 3130-1533 38.1 µM 0.620978445084714 0.26429574849786 no 893 0.267306902767427 1348 720941
SGTC_1581 himbacine 57.9 µM 0.620553148950348 0.264440146511209 no 894 0.267446836936038 1300 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_791 1348-1292 225 µM 0.618022512338322 0.265300186456277 no 895 0.268280249478878 1312 5437054
SGTC_2914 7968218 45.32 µM 0.617267564414343 0.265557031132934 no 896 0.268529128651306 1317 2977111
SGTC_1245 0418-0076 17.2 µM 0.616357667206416 0.265866759422808 no 897 0.268829243184382 1335 6790114
SGTC_1197 1601-0112 267 µM 0.615352149109279 0.266209249794416 no 898 0.269161092505518 1303 7350313
SGTC_3204 9114183 49.47 µM 0.615183729968749 0.266266637011159 no 899 0.269216695658269 1337 17027248
SGTC_3229 9132204 49.47 µM 0.615174384413881 0.266269821603257 no 900 0.269219781238267 1325 17682924
SGTC_2963 9082507 9 µM 0.614977460038829 0.266336930053244 no 901 0.269284803002148 1332 16459611
SGTC_3246 9135460 32.98 µM 0.614109084740787 0.266632959514711 no 902 0.269571622681298 1273 41446951
SGTC_826 1683-5028 118 µM 0.613859165508365 0.26671818789168 no 903 0.269654198014595 1341 722377
SGTC_780 0109-0199 192 µM 0.612591245208107 0.267150790778801 no 904 0.270073324239409 1389 610414
SGTC_319 1348-1596 45.5 µM 0.612014410081533 0.267347718842024 no 905 0.270264111800783 1400 5380505
SGTC_2312 7706453 155.7 µM 0.611817631719053 0.267414914547157 no 906 0.270329211432323 1338 976098
SGTC_2972 9093619 59.92 µM 0.610180158419894 0.267974407697375 no 907 0.270871235948607 1290 25236256
SGTC_2146 5545642 200 µM 0.609546614661838 0.268191035455294 no 908 0.271081092425151 1333 825326
SGTC_527 4476-4215 268 µM 0.607134524303029 0.269016607652653 no 909 0.271880820056742 1350 4418754
SGTC_1263 0774-1208 64.8 µM 0.606739431133213 0.269151955383067 no 910 0.272011924833391 1380 906585
SGTC_3064 1327-0027 10 µM 0.603342828965393 0.270316942656965 no 911 0.27314032330657 1248 16000455 YPR107C YTH1
SGTC_476 mead acid 10 µM 0.603066327968003 0.270411889491957 no 912 0.273232282783437 1364 5312531 An omega 9 fatty acid.
SGTC_875 0709-0210 25.7 µM 0.600898348811851 0.27115692243333 no 913 0.273953846526475 1359 6251364
SGTC_3251 9135047 49.47 µM 0.600583203351135 0.271265308319074 no 914 0.274058814053555 1393 17682963
SGTC_49 0717-0965 32.132 µM 0.599300201166402 0.271706785537507 no 915 0.274486356882184 1412 5889349 YGL099W LSG1
SGTC_669 0108-0021 26.2 µM 0.599246903854922 0.271725132717351 no 916 0.274504124595648 1526 17201
SGTC_2099 5377090 177.372 µM 0.599176434620611 0.271749392143078 no 917 0.27452761778058 1318 2243829
SGTC_1977 st070720 65.3 µM 0.59811543688552 0.272114776756918 no 918 0.274881455349305 1336 682188
SGTC_1053 3366-3204 134 µM 0.597440928096556 0.272347189879211 no 919 0.27510651754353 1290 3632071 YPR165W RHO1
SGTC_1863 st057641 20.1 µM 0.596190231131644 0.27277839891966 no 920 0.275524075458699 1332 3921635
SGTC_2948 9070189 9.45 µM 0.593688697468633 0.273641880138507 no 921 0.276360172014032 1298 6473636 YDL196W YDL196W
SGTC_560 2332-1943 155 µM 0.59244334261337 0.274072256284153 no 922 0.276776874942195 1345 21177716
SGTC_2896 9052656 71.43 µM 0.592104052106666 0.274189567989932 no 923 0.276890456833917 1318 6469436
SGTC_3339 9145883 14.936 µM 0.591314122194486 0.274462786994054 no 924 0.277154984501921 1304 2030670
SGTC_1410 3909-8106 77.9 µM 0.590691546023243 0.274678216731029 no 925 0.277363556702202 1389 1039210
SGTC_559 1550-0661 158 µM 0.588753834402259 0.275349255361284 no 926 0.278013209405888 1399 5830875
SGTC_3078 9116413 49.47 µM 0.584424984767252 0.276851264320498 no 927 0.279467210629203 1286 17177322
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.584236430454665 0.276916779319057 no 928 0.279530627274666 1333 4174840
SGTC_2744 captopril 92.04 µM 0.583460757106299 0.277186374262966 no 929 0.279791583676027 1411 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_622 1348-1566 26.3 µM 0.580463622298937 0.27822927083506 no 930 0.280801005779423 1428 7340407
SGTC_198 3454-2873 16.191 µM 0.579190415809862 0.278672879798881 no 931 0.281230348519557 1341 710957
SGTC_1025 k007-0731 70 µM 0.577974247341372 0.279096936973125 no 932 0.281640753022012 1337 6256118
SGTC_354 2783-3500 4.88 µM 0.57706864275645 0.279412909494575 no 933 0.28194654305648 1326 6740761
SGTC_1324 1418-0026 34.4 µM 0.577036095180226 0.279424268832265 no 934 0.281957536176795 1390 1372513
SGTC_2322 7413319 38.22 µM 0.576300094389263 0.279681198257911 no 935 0.28220617954146 1415 1840400
SGTC_304 1310-0298 97 µM 0.576143944914261 0.279735722985624 no 936 0.282258945131778 1318 1550234
SGTC_2315 7733312 200 µM 0.57493596498496 0.280157703127881 no 937 0.282667302653653 1347 726316
SGTC_2536 dehydroabietamide 32.04 µM 0.574311768529138 0.280375872677443 no 938 0.28287842341822 1465 3983547
SGTC_588 3970-1144 52.9 µM 0.574047762872605 0.280468172854508 no 939 0.282967740324709 1356 1888707
SGTC_566 0958-0068 16.5 µM 0.573396852354978 0.280695803355525 no 940 0.283188010528298 1364 6815365
SGTC_2955 9076254 12.21 µM 0.572463752020101 0.281022274500499 no 941 0.283503918079713 1335 16459619
SGTC_1071 trifluoperazine 6.31 µM 0.571641494858637 0.281310116062707 no 942 0.283782438823474 1453 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3116 9124943 49.47 µM 0.569890958217384 0.281923387245587 no 943 0.284375828915099 1295 41905195 YPL160W CDC60
SGTC_1613 st002381 52.1 µM 0.569068293827279 0.28221181623352 no 944 0.284654897131335 1371 551167
SGTC_2037 5169046 200 µM 0.568660891203945 0.28235470556927 no 945 0.284793146620141 1402 5718022
SGTC_624 k048-0052 28 µM 0.56797656185597 0.282594800406983 no 946 0.285025441516791 1361 6835531
SGTC_761 k216-0224 480 µM 0.567715744829247 0.282686333077399 no 947 0.285113999361619 1470 1340404
SGTC_2852 9023854 51.95 µM 0.566936587262285 0.28295986006523 no 948 0.285378632703924 1459 19798528
SGTC_872 0588-0139 234 µM 0.565813374682969 0.283354392688216 no 949 0.285760326747369 1376 2047100
SGTC_2923 7992654 58.14 µM 0.565054079125651 0.283621247429038 no 950 0.286018490712253 1402 2985126
SGTC_2647 atorvastatin 60.16 µM 0.564641077452036 0.283766447575196 no 951 0.286158959696807 1424 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1826 st055655 41.6 µM 0.564306399763757 0.283884137242669 no 952 0.286272813375868 1424 676168
SGTC_2350 9023895 38.85 µM 0.563268328722781 0.284249324265179 no 953 0.286626090513643 1451 2997209
SGTC_1649 st011737 51.3 µM 0.560021619710661 0.285392943925321 no 954 0.287732345582389 1374 1761035
SGTC_2289 7946404 165.07 µM 0.558536052751388 0.285916949197302 no 955 0.288239196425067 1412 1246120 YPR165W RHO1
SGTC_1119 parthenolide 318.541 nM 0.556867307678253 0.28650611193178 no 956 0.288809046314637 1507 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2866 9034245 58.44 µM 0.556604697124576 0.28659888095038 no 957 0.288898771914884 1407 6462273
SGTC_2673 kobusone 100 µM 0.556057784425478 0.286792127413191 no 958 0.289085676533095 1455 6710676 An epoxy ketone and protein crosslinker.
SGTC_1169 aniline yellow 25.8 µM 0.555095156893781 0.287132412748968 no 959 0.289414787635348 1414 6051 A DNA damaging agent.
SGTC_2347 9049783 174.81 µM 0.554678007101781 0.287279933028705 no 960 0.289557460917072 1456 6467988 YPL169C MEX67
SGTC_1473 k844-0725 134 µM 0.554311557095254 0.287409553490241 no 961 0.289682821134869 1439 54682906
SGTC_1034 k072-0165 12.7 µM 0.553918323543474 0.287548678572635 no 962 0.289817372159647 1480 5835461
SGTC_1463 k081-0032 34.1 µM 0.552750619907456 0.287961996846208 no 963 0.290217092959683 1302 977755
SGTC_2060 5238662 140 µM 0.551944877371506 0.288247359465104 no 964 0.290493060068443 1393 790130
SGTC_2183 6420625 130.508 µM 0.550255785462722 0.28884600249968 no 965 0.291071972906686 1390 2897619
SGTC_1063 disulfiram 1.84 µM 0.550211991190173 0.288861531718308 no 966 0.291086989951035 1389 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1821 st053465 65.6 µM 0.546942894117904 0.290021844240571 no 967 0.292208982731218 1372 675086
SGTC_1367 1812-0510 76.9 µM 0.544834100858569 0.290771483336707 no 968 0.292933811436768 1430 1142582 YDR527W RBA50
SGTC_178 4092-0806 87.505 µM 0.544718648121357 0.290812550909805 no 969 0.292973518618123 1411 2169044
SGTC_702 1488-0190 94 µM 0.543301977430465 0.291316694008042 no 970 0.293460951504306 1469 949357
SGTC_1935 st074532 41.6 µM 0.542617001375062 0.2915605990059 no 971 0.293696765379982 1515 2829742
SGTC_2924 9010168 62.78 µM 0.541632605724907 0.291911287435755 no 972 0.294035812700675 1424 2993929
SGTC_2635 hydroquinidine 100 µM 0.541030058520961 0.292126040212733 no 973 0.294243432321532 1450 442912 An experimental heart treatment.
SGTC_2986 9022445 71.43 µM 0.540678947720185 0.292251212883852 no 974 0.294364445749184 1477 6459286
SGTC_2079 5212404 121 µM 0.539553471430046 0.292652618609238 no 975 0.294752505864322 1490 758462
SGTC_1579 chlormadinone acetate 49.4 µM 0.538866937662157 0.292897599379269 no 976 0.294989335972985 1510 45114258 A steroidal progestin.
SGTC_2126 5251174 33.877 µM 0.537421599944663 0.293413660480446 no 977 0.295488213219094 1546 790722
SGTC_2586 curcumin 80 µM 0.537132330552361 0.29351699534054 no 978 0.295588104919466 1498 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3332 9141069 11.198 µM 0.535248903920479 0.294190218077273 no 979 0.296238876851348 1385 17332883
SGTC_2043 5101342 149 µM 0.534308051740753 0.294526788627586 no 980 0.296564211216409 1399 678451
SGTC_269 exalamide 29 µM 0.533919395120724 0.294665874397271 no 981 0.29669865134461 1472 3316 A derivative of salicylamide.
SGTC_1839 st053978 48 µM 0.532026502892815 0.295343702894564 no 982 0.297353819871439 1454 3788398
SGTC_776 4476-4378 112 µM 0.531741111258633 0.295445961403315 no 983 0.297452657033104 1429 2892008
SGTC_2074 5212007 75.395 µM 0.531105827511666 0.295673648002791 no 984 0.297672723087277 1430 758611
SGTC_2376 9072922 81.32 µM 0.529436766995903 0.296272225586694 no 985 0.298251249232644 1469 17087968
SGTC_2707 st078556 66.6 µM 0.529171788455548 0.296367306318888 no 986 0.298343142594858 1469 17250899
SGTC_537 1334-0398 209 µM 0.527796932145085 0.296860862575753 no 987 0.298820143340296 1522 5846986
SGTC_2076 5212012 200 µM 0.526086014646257 0.297475585367031 no 988 0.299414222618311 1397 604802
SGTC_2022 5136654 200 µM 0.525917184311533 0.297536276629218 no 989 0.299472874338166 1464 1713771
SGTC_372 0155-0182 15.9 µM 0.525312090212168 0.297753842757049 no 990 0.299683127022135 1455 771486
SGTC_2518 prenyletin 46.28 µM 0.525160052589821 0.297808520432259 no 991 0.299735966204535 1400 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1711 st032263 62.8 µM 0.524832772250889 0.29792623662566 no 992 0.29984972358697 1484 3958979
SGTC_3017 9080681 49.47 µM 0.5247892613641 0.297941888218993 no 993 0.299864848743348 1415 16451914
SGTC_2697 mebhydrolin 72.4 µM 0.524200355025076 0.298153764533069 no 994 0.300069597000061 1551 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2435 5706476 10.6 µM 0.523060433177898 0.298564079702787 no 995 0.300466099369371 1494 5725375
SGTC_955 1216-0110 33 µM 0.521496918399184 0.299127284591713 no 996 0.301010325866004 1387 3619719
SGTC_2015 5119600 184 µM 0.520725750604055 0.299405249952971 no 997 0.301278916636041 1539 2828786
SGTC_1299 1079-1439 3.74 µM 0.520416527879726 0.299516741343212 no 998 0.301386646422675 1400 323161
SGTC_815 1582-0027 36.9 µM 0.520138900965631 0.299616856777132 no 999 0.301483383348687 1506 3128206
SGTC_685 1278-0033 54.9 µM 0.519750677790905 0.299756879905223 no 1000 0.301618680101782 1524 3590572
SGTC_1846 st056244 14.8 µM 0.518933735575558 0.300051628835014 no 1001 0.301903475678199 1483 5393182
SGTC_2605 digitonin 300 nM 0.518387261448167 0.300248867299884 no 1002 0.302094050344233 1505 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1799 st045822 46.1415 µM 0.517532037150531 0.300557660291731 no 1003 0.302392405363216 1505 3674992
SGTC_3152 9099253 49.47 µM 0.51592480052743 0.301138367496885 no 1004 0.302953465928174 1477 25236131
SGTC_2561 acetosyringone 100 µM 0.5148603367348 0.301523244681314 no 1005 0.303325309460022 1421 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_660 4031-1742 102 µM 0.513103996984495 0.302158766175855 no 1006 0.303939287875416 1447 6738706
SGTC_192 3455-0609 60.9 µM 0.512750938771981 0.302286590819112 no 1007 0.304062776262585 1477 3769639
SGTC_3012 9080433 71.4286 µM 0.512604168362897 0.302339736149821 no 1008 0.304114118402306 1536 17688859
SGTC_505 gw-5074 63.9 µM 0.510165893938326 0.30322324387197 no 1009 0.304967622056693 1527 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3209 9113616 49.47 µM 0.510135131466824 0.303234398011409 no 1010 0.304978397073365 1594 16649353
SGTC_2612 dictamnine 15.46 µM 0.506122882762461 0.304690765138253 no 1011 0.30638519378423 1482 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_569 4130-2812 160 µM 0.505931398946502 0.304760347686279 no 1012 0.306452404522141 1451 743552
SGTC_1495 4469-0029 237 µM 0.504378547236117 0.305324893055329 no 1013 0.30699769516994 1455 793680
SGTC_2432 5630864 12.22 µM 0.503621006533607 0.305600468217331 no 1014 0.307263864006152 1450 5714970
SGTC_798 1287-0182 476 µM 0.500568676249211 0.306711947741723 no 1015 0.308337356008414 1584 1649755
SGTC_410 α-linolenic acid 100 µM 0.499975095264278 0.306928302109794 no 1016 0.308546306874498 1521 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.499334851666578 0.307161739935465 no 1017 0.308771753318774 1579 5282309
SGTC_2495 cafestol 54.53 µM 0.498671060014278 0.307403846106614 no 1018 0.309005567756973 1515 16667697 An anti-infammatory.
SGTC_314 1671-0008 2.74 µM 0.498625530727856 0.30742045517951 no 1019 0.30902160786251 1424 3913060
SGTC_3312 9133330 71.43 µM 0.49668732219309 0.30812787907433 no 1020 0.309704781994931 1563 17617324
SGTC_39 0986-0283 58.349 µM 0.496292478072465 0.308272080205032 no 1021 0.309844036246063 1615 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1097 itavastatin 7.23 µM 0.496137424543449 0.308328715440667 no 1022 0.309898728234383 1489 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2760 etidronate 98.04 µM 0.496000058375373 0.308378893958584 no 1023 0.309947184879745 1443 3305 A chelator and antioxidant.
SGTC_862 0452-0056 10.2 µM 0.495856359025902 0.308431389757281 no 1024 0.309997879121948 1460 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_977 1348-1378 135 µM 0.495346796764838 0.308617573020986 no 1025 0.310177671556143 1449 X977
SGTC_2811 7967822 32.47 µM 0.494697742119021 0.308854795111798 no 1026 0.310406747789086 1557 2232244
SGTC_1612 st002233 45.4 µM 0.491885675722384 0.309883493812146 no 1027 0.311400082548997 1504 1035021
SGTC_1339 1486-1321 22.7 µM 0.491589053765411 0.309992089880933 no 1028 0.311504941602618 1489 3469382
SGTC_837 0091-0265 12.5 µM 0.489270604621946 0.310841466364517 no 1029 0.312325064625167 1453 759367
SGTC_334 1502-1024 68.5 µM 0.486620057443262 0.311813744846198 no 1030 0.313263803452078 1510 3296216
SGTC_547 1120-0019 610 nM 0.486576856178538 0.311829602904494 no 1031 0.31327911400323 1513 3676939
SGTC_2652 actinonin 100 µM 0.485468337945089 0.312236630314212 no 1032 0.313672083472667 1508 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3111 9122088 49.47 µM 0.485364605137107 0.312274730822875 no 1033 0.313708867559558 1508 16876704
SGTC_615 k087-0205 167 µM 0.484685802865626 0.312524100821967 no 1034 0.313949619378877 1449 9642773
SGTC_3163 9099914 49.47 µM 0.48326927097197 0.313044765281664 no 1035 0.314452277927334 1559 16268368
SGTC_1575 cyproterone acetate 48 µM 0.482069902616585 0.31348590020857 no 1036 0.314878144795974 1441 9880 An androgen receptor antagonist and liver toxin.
SGTC_1165 k072-0275 30.3 µM 0.481607799601419 0.313655935755627 no 1037 0.315042292222052 1506 6153523 YGL055W OLE1
SGTC_3044 9093193 49.47 µM 0.480245229534936 0.314157537795617 no 1038 0.315526514571678 1451 25236277
SGTC_3248 9135562 49.47 µM 0.479414420928161 0.314463551457761 no 1039 0.315821918174263 1518 17650701
SGTC_2968 9090663 33.37 µM 0.479111649414581 0.314575103708258 no 1040 0.315929601351943 1521 25236811
SGTC_645 0845-0943 5.41 µM 0.479047134746911 0.31459887549186 no 1041 0.315952548543078 1496 1885106
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.477864036295508 0.31503494914669 no 1042 0.316373489942614 1545 7104
SGTC_1060 3448-7350 82 µM 0.476269501629542 0.315623080500995 no 1043 0.316941195137629 1620 570178
SGTC_1769 st044406 64.4 µM 0.473788627653397 0.316539059750495 no 1044 0.317825322519063 1525 670903
SGTC_2807 7945238 51.95 µM 0.472929245595766 0.316856620620844 no 1045 0.318131829550082 1562 17148797
SGTC_136 0097-0015 404.482 µM 0.471659388843449 0.317326108108486 no 1046 0.318584964431752 1538 4861337
SGTC_38 0929-0051 58.268 µM 0.469904829849867 0.31797528199485 no 1047 0.319211506730695 1638 1379719
SGTC_1628 st004252 77.7 µM 0.469634990238296 0.318075170370947 no 1048 0.319307910695699 1635 692968
SGTC_373 0844-0104 25.9 µM 0.46897366117971 0.318320035028982 no 1049 0.319544231379625 1622 5375804
SGTC_2423 st077119 87.2 µM 0.468155278949197 0.318623160344199 no 1050 0.319836775242987 1463 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3307 9126885 69.2785 µM 0.465699980888506 0.319533320329541 no 1051 0.320715133024879 1476 24824909
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.463928368620213 0.320190719538702 no 1052 0.321349533584694 1491 4000243
SGTC_1873 rapamycin 2 nM 0.463143482832367 0.320482150911509 no 1053 0.321630761909567 1519 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3117 9124945 49.47 µM 0.461575021693334 0.321064858664266 no 1054 0.322193055208832 1424 17592065
SGTC_1024 4507-0395 26 µM 0.45969257344448 0.321764799638359 no 1055 0.322868450456355 1563 4201836
SGTC_3144 9087057 49.47 µM 0.459195313126675 0.321949799157977 no 1056 0.323046957981393 1665 17249618
SGTC_1644 st010134 20.9 µM 0.458644553400083 0.322154753982718 no 1057 0.323244718411746 1539 3818134
SGTC_577 r071-0003 38.6 µM 0.458243925180697 0.322303874192523 no 1058 0.323388602749213 1523 4568517 YMR134W ERG29
SGTC_2745 rifampicin 24.3 µM 0.458045440247634 0.322377764045519 no 1059 0.323459897762395 1650 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_589 1227-0070 34.1 µM 0.456810458181806 0.322837667576723 no 1060 0.323903644052107 1551 2841384
SGTC_2827 7993847 71.43 µM 0.455644687448351 0.323272045767895 no 1061 0.324322751507528 1572 2985692
SGTC_2123 5259487 200 µM 0.455339026451609 0.323385978115675 no 1062 0.324432676877626 1645 2173474
SGTC_1718 roemerine 11.9335 µM 0.455212705012544 0.32343306811717 no 1063 0.324478110534508 1513 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2791 5663188 71.43 µM 0.454808877425251 0.323583625600768 no 1064 0.324623371527205 1623 54690634
SGTC_2611 pyromycin 23.93 µM 0.45365271084209 0.324014834386405 no 1065 0.325039404183276 1520 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2395 5646831 180.19 µM 0.452625795082989 0.324398035373894 no 1066 0.325409110525542 1609 6808628
SGTC_2864 9034755 47.6 µM 0.45241055685823 0.324478376658103 no 1067 0.325486621579067 1532 4930451
SGTC_439 amiodarone 34.4 µM 0.452082926275223 0.324600685960709 no 1068 0.325604621577119 1615 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1141 3253-0389 52.6 µM 0.450516246238832 0.325185811937721 no 1069 0.326169121225067 1603 5402031
SGTC_384 k007-0144 5.16 µM 0.450152822969171 0.32532160548178 no 1070 0.326300125381734 1576 6824886
SGTC_1222 0366-0074 1.18 µM 0.448280196695273 0.326021681926635 no 1071 0.326975495431767 1675 286520
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.447935762974348 0.326150514466491 no 1072 0.327099778622993 1547 442882
SGTC_850 0388-0143 75.9 µM 0.447452007596717 0.326331494139025 no 1073 0.327274366099203 1532 67273
SGTC_2628 lathosterol 100 µM 0.445202971272101 0.327173426663443 no 1074 0.328086539842939 1583 6710616
SGTC_1885 st057546 99.9 µM 0.44325610204822 0.327902953153705 no 1075 0.328790251880213 1620 702008
SGTC_297 0986-0032 24 µM 0.440415389296057 0.328968597259846 no 1076 0.329818140457063 1547 2847425
SGTC_1406 3909-7906 11.9 µM 0.439614721263974 0.329269205756404 no 1077 0.33010808835372 1605 X1406
SGTC_2570 licareol 100 µM 0.439076186658849 0.329471459133553 no 1078 0.330303166650454 1532 443158
SGTC_1067 clotrimazole 1.36 µM 0.438591003894169 0.329653718293332 no 1079 0.330478958329298 1571 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2342 7990637 118.86 µM 0.438469512165165 0.329699363061395 no 1080 0.330522983135797 1607 2033102 YER133W GLC7
SGTC_2366 9070441 60.58 µM 0.438333320813709 0.32975053353258 no 1081 0.33057233741424 1517 6837235
SGTC_1266 0828-0227 32.9 µM 0.438226705082705 0.329790593932975 no 1082 0.330610975862621 1616 3913820
SGTC_3030 9087619 49.47 µM 0.437323526026873 0.330130037855842 no 1083 0.330938368028753 1539 25236973
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.434806040757132 0.331076927913194 no 1084 0.331851609912768 1663 688798
SGTC_1175 0741-0056 27.6 µM 0.434535273944521 0.331178834692465 no 1085 0.331949892822575 1681 765927
SGTC_2985 9022375 71.43 µM 0.430964236124944 0.33252401100799 no 1086 0.333247187552211 1576 4939335
SGTC_2059 5238311 157 µM 0.430935184320525 0.332534963427967 no 1087 0.333257749769598 1553 703021
SGTC_1107 amlodipine 47 µM 0.430455164047626 0.332715949938594 no 1088 0.333432287446298 1531 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2131 toluylene red 5.2905 µM 0.429171200971868 0.333200246027359 no 1089 0.333899319760937 1516 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1306 1185-0270 9.02 µM 0.426143650484585 0.334343303682217 no 1090 0.335001587446806 1670 1548076
SGTC_2082 5219693 150 µM 0.426057263190636 0.334375941988618 no 1091 0.335033060170968 1550 2834649
SGTC_2902 5787006 60.46 µM 0.425090177855233 0.334741405526462 no 1092 0.335385468905013 1558 591003
SGTC_1570 verbenone 133 µM 0.424094110580152 0.335117985113828 no 1093 0.335748590223453 1707 29025 A natural terpanoid with antifungal properties.
SGTC_1872 amphotericin b 148 nM 0.423366393747247 0.335393215247688 no 1094 0.336013980050928 1665 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2523 spermine 47.74 µM 0.42267647460715 0.335654231506311 no 1095 0.336265661019086 1701 1103 A DNA binding polyamine.
SGTC_3280 9140961 49.47 µM 0.422242968205876 0.335818280035112 no 1096 0.336423840748562 1577 4901226
SGTC_950 1165-0508 94.1 µM 0.422054720886912 0.335889526781056 no 1097 0.336492538280048 1549 6148369
SGTC_3109 9122853 49.47 µM 0.421572955222786 0.336071889492853 no 1098 0.336668374997677 1649 1234709
SGTC_150 3970-0969 77.2 µM 0.420731345993926 0.336390556328979 no 1099 0.336975634502561 1628 6615640
SGTC_1219 1469-0211 33.1 µM 0.419855072627593 0.336722473325647 no 1100 0.337295665018589 1683 6822282
SGTC_425 3825-7017 13.1 µM 0.419715905297204 0.336775199185678 no 1101 0.337346502228379 1662 3397440
SGTC_2381 9035592 200 µM 0.419455908808858 0.336873711778936 no 1102 0.337441485750228 1521 4749657
SGTC_970 1315-0089 19.5 µM 0.419047241894206 0.337028578172165 no 1103 0.337590803405914 1518 6811083 YLR033W RSC58
SGTC_1476 4112-3294 3.34 µM 0.418690498565584 0.337163790446286 no 1104 0.337721170262897 1689 704369
SGTC_361 000s-0510 1.45 µM 0.417068718992797 0.3377787396801 no 1105 0.33831407220106 1606 660
SGTC_3097 9117246 49.47 µM 0.417016875321905 0.337798405010111 no 1106 0.338333032210237 1586 16423892
SGTC_404 fumagillin 50 µM 0.415331452993102 0.338437959962891 no 1107 0.338949639509374 1619 12015870 A methionine aminopeptidase binder.
SGTC_2976 9009005 19.48 µM 0.414813281752974 0.3386346804411 no 1108 0.33913929793407 1751 2993148
SGTC_1811 st050069 61.5 µM 0.41377763401936 0.339027989550445 no 1109 0.33951848262824 1643 3877702
SGTC_2645 abamectin 100 µM 0.413725912578353 0.339047636465511 no 1110 0.33953742381258 1668 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3304 9125678 46.087 µM 0.41301621513303 0.339317266445265 no 1111 0.339797366812797 1584 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1075 aripiprazole 15.2 µM 0.412457276591419 0.339529677671689 no 1112 0.340002144547291 1593 60795 An atypical antipschotic. YIL048W NEO1
SGTC_283 0987-0079 11.7 µM 0.412130318709761 0.339653953835592 no 1113 0.340121953658422 1683 411556
SGTC_628 1636-0253 16 µM 0.410806450653238 0.340157332044105 no 1114 0.340607231388644 1683 4456143
SGTC_3067 9117431 49.47 µM 0.410658945717547 0.340213435939586 no 1115 0.340661317229445 1616 17150885
SGTC_14 0354-0009 295 µM 0.40998570075653 0.340469551360087 no 1116 0.340908218487988 1656 1713507
SGTC_1295 1013-0063 9.78 µM 0.409430842052133 0.340680685679655 no 1117 0.341111754818437 1722 6826038
SGTC_3199 9111318 49.47 µM 0.409426884542018 0.340682191767128 no 1118 0.341113206700281 1680 8548020
SGTC_1832 st054113 55 µM 0.409310031431422 0.340726663045984 no 1119 0.34115607736904 1654 1251267
SGTC_1150 3909-7983 10.9 µM 0.408408231441296 0.341069939282424 no 1120 0.341486995596839 1574 23965914
SGTC_1833 st055984 71 µM 0.405022499448772 0.34235991346478 no 1121 0.34273048629375 1625 676288
SGTC_1362 1611-0397 101 µM 0.402241408515191 0.343420895913469 no 1122 0.343753185172808 1609 27816
SGTC_3344 9148862 3.898 µM 0.401476310261423 0.343712996844133 no 1123 0.344034738096744 1698 4905352
SGTC_828 2074-0507 139 µM 0.400253811272588 0.34417991890715 no 1124 0.344484792022357 1724 X828
SGTC_731 3966-0296 387 µM 0.40000557170733 0.344274760739267 no 1125 0.344576206498522 1630 660956
SGTC_199 4063-0024 41.6 µM 0.399011931226256 0.344654486726813 no 1126 0.344942206472808 1708 306215
SGTC_2677 mitomycin C 100 µM 0.398536836710273 0.344836102451956 no 1127 0.345117255260081 1625 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_627 1391-0720 175 µM 0.398314552441876 0.344921087970355 no 1128 0.345199167382848 1629 997839
SGTC_2739 tacrine 100.86 µM 0.396397406589832 0.345654391023996 no 1129 0.345905939488685 1632 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2721 ifenprodil 61.44 µM 0.3936011144662 0.346725003647025 no 1130 0.346937779143717 1719 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1726 st035556 14.5795 µM 0.391533309334316 0.347517489989913 no 1131 0.347701536245582 1738 5919439
SGTC_426 0988-0037 14.6 µM 0.390386014210397 0.347957478767518 no 1132 0.348125564069919 1753 5383008
SGTC_1163 k060-0048 49.9 µM 0.390031757733077 0.34809337787324 no 1133 0.34825653182363 1645 6809982
SGTC_2024 5144227 134 µM 0.389668150039494 0.348232884562819 no 1134 0.348390975519106 1707 3475211
SGTC_468 gf-109203x 121 µM 0.389070656763963 0.348462171581702 no 1135 0.348611939613038 1715 2396 A protein kinase C inhibitor.
SGTC_21 0849-0113 22.993 µM 0.388932253045322 0.348515291674165 no 1136 0.348663131205651 1609 1560156
SGTC_3031 9088762 49.47 µM 0.388525554598125 0.348671401915267 no 1137 0.348813573318123 1581 205253
SGTC_759 3486-0358 89.3 µM 0.386921328698219 0.349287429943719 no 1138 0.349407225298444 1810 875103
SGTC_644 1498-1197 63.3 µM 0.386901529736654 0.349295035295101 no 1139 0.349414554310529 1708 6741615
SGTC_2771 fluoxetine 41.05 µM 0.385939619360071 0.349664605611485 no 1140 0.349770693731624 1703 3386 A selective serotonin reuptake inhibitor.
SGTC_1515 3460-0031 42.1 µM 0.384144035978127 0.350354857958439 no 1141 0.350435847337215 1637 2876596
SGTC_485 niflumic acid 177 µM 0.383500924161126 0.350602201319353 no 1142 0.350674192577504 1690 4488 A COX2 inhibitor.
SGTC_1860 st056228 74.6 µM 0.383074748169222 0.350766145206498 no 1143 0.35083217109604 1611 688679
SGTC_1287 0971-0001 34.6 µM 0.382814449708681 0.350866292022709 no 1144 0.350928673418912 1686 4665869
SGTC_12 0849-0099 9.267 µM 0.382809228378671 0.350868300974953 no 1145 0.350930609258592 1726 6071388
SGTC_2659 sanguinarine 24.21 µM 0.380364483763771 0.351809394905785 no 1146 0.351837437383881 1660 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1554 st069299 38.7 µM 0.380041698290994 0.351933717818448 no 1147 0.351957231215991 1700 24207999
SGTC_620 0109-0052 432 µM 0.380011353642257 0.35194540607048 no 1148 0.351968493636559 1750 493037
SGTC_1044 1222-0021 1.78 µM 0.379880910188098 0.351995652304245 no 1149 0.352016909221558 1696 4306703
SGTC_1157 4092-0394 27.6 µM 0.379367506402992 0.352193438237338 no 1150 0.352207488225732 1736 3659885
SGTC_466 geldanamycin 89.2 µM 0.378603308729553 0.352487915156812 no 1151 0.352491232380019 1732 5288382 HSP90 inhibitor.
SGTC_725 1497-0963 19 µM 0.378414587231157 0.352560650966113 no 1152 0.352561316716837 1797 3549977
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.378226038968573 0.352633325391757 no 1153 0.352631341718502 1633 6312947
SGTC_2670 beta-carotene 100 µM 0.376680873677563 0.353229099488541 no 1154 0.35320538913137 1682 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3242 9133940 49.47 µM 0.376614544051449 0.35325468247128 no 1155 0.353230038871674 1706 17248444
SGTC_3205 9113483 49.47 µM 0.372977616803574 0.354658438084546 no 1156 0.354582551548527 1773 17018033
SGTC_1735 st034310 56.75 µM 0.372516988133619 0.354836369678729 no 1157 0.354753982987459 1755 871153
SGTC_3240 9133527 49.47 µM 0.372232632031784 0.35494622653625 no 1158 0.354859826033251 1654 17617455
SGTC_1757 st041620 31.8375 µM 0.371566804951182 0.355203506346119 no 1159 0.355107704047881 1640 5289815
SGTC_2225 6654152 15.4 µM 0.3698195808137 0.355878958511388 no 1160 0.35575846230724 1728 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1695 st026914 34.495 µM 0.369562413771131 0.355978413923196 no 1161 0.355854280406292 1649 3289191
SGTC_1847 st056231 15 µM 0.368584497026344 0.356356697683178 no 1162 0.356218726395611 1629 5393180
SGTC_1922 5578187 25 µM 0.368318713484269 0.356459534155603 no 1163 0.356317800232316 1772 1350412
SGTC_2063 5246145 200 µM 0.368296015355319 0.356468316957173 no 1164 0.356326261667523 1715 711240
SGTC_2920 7982904 15.77 µM 0.367901519467484 0.356620975134276 no 1165 0.356473333603342 1630 6456808
SGTC_2543 pimpinellin 60.67 µM 0.367006869201319 0.356967263266823 no 1166 0.356806947065322 1625 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2254 7938975 95.19 µM 0.366193748582936 0.357282096363345 no 1167 0.357110253312048 1775 2969277
SGTC_116 0155-0182 31.788 µM 0.366121999895522 0.357309881488053 no 1168 0.357137020993203 1662 771486
SGTC_124 0136-0217 7.121 µM 0.364587117912989 0.357904455053583 no 1169 0.357709816159913 1772 3976905
SGTC_2477 5967686 25.23 µM 0.364166994575191 0.358067260144938 no 1170 0.357866655892191 1629 776118
SGTC_3239 9133757 49.47 µM 0.363798014194031 0.358210267745291 no 1171 0.358004422816801 1739 17036923
SGTC_575 k072-0246 11.9 µM 0.36359757575561 0.358287961028755 no 1172 0.358079268660552 1690 6796779
SGTC_2249 haloperidol 116.36 µM 0.361894135127418 0.358948479576886 no 1173 0.358715571407718 1737 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1066 ketoconazole 628 nM 0.360604810116969 0.359448703178976 no 1174 0.359197446496487 1759 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1046 2001-0062 216 µM 0.359469249857634 0.359889469782727 no 1175 0.359622038840154 1651 739778
SGTC_2512 diallyl trisulfide 49.23 µM 0.359148750996996 0.360013904853073 no 1176 0.359741906548664 1687 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1485 3909-9022 254 µM 0.358818925917374 0.360141976358078 no 1177 0.359865276702483 1696 714516
SGTC_149 3970-0822 46.1 µM 0.358803931273919 0.360147799170704 no 1178 0.359870885754254 1686 3114250 YBL034C STU1
SGTC_2292 7671323 168.05 µM 0.35871051209173 0.360184077015653 no 1179 0.359905831781596 1662 937504
SGTC_988 1497-1057 103 µM 0.35844211528635 0.360288311625545 no 1180 0.360006239540117 1824 3533044
SGTC_2450 5739737 12.93 µM 0.35780002123089 0.360537717466929 no 1181 0.360246487342078 1693 2262825
SGTC_613 3914-0030 117 µM 0.357278926296457 0.36074016776633 no 1182 0.360441502338481 1700 1145395
SGTC_1568 digitonin 820 nM 0.356976748089588 0.360857584735282 no 1183 0.360554606395068 1849 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1521 st012942 49.4 µM 0.356539436558983 0.361027533496371 no 1184 0.360718311900889 1863 24207259
SGTC_2341 7987486 176.74 µM 0.356107315066576 0.361195492248716 no 1185 0.360880099614657 1840 1258686
SGTC_2918 7977171 22.06 µM 0.355665611696292 0.361367202983441 no 1186 0.361045500547272 1677 2236483
SGTC_944 3370-0224 231 µM 0.355626206505963 0.361382522979274 no 1187 0.361060257539241 1638 4580514
SGTC_3052 9092717 49.47 µM 0.354734865976084 0.361729118724099 no 1188 0.361394114077348 1681 25237534
SGTC_3007 9078383 71.4286 µM 0.35387725322731 0.362062706609806 no 1189 0.361715437352452 1676 6496995
SGTC_1464 k208-0027 110 µM 0.353675723197578 0.362141111492648 no 1190 0.361790959122879 1800 X1464
SGTC_1372 2752-0194 270 µM 0.353434690795147 0.362234892296468 no 1191 0.361881291161261 1654 823334
SGTC_2391 6285546 200 µM 0.350306932349002 0.36345258752342 no 1192 0.363054181611176 1656 846083
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.349131575982983 0.363910533536031 no 1193 0.363495266041335 1717 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_379 3970-0972 5.9 µM 0.347568482738461 0.36451985195428 no 1194 0.364082139657457 1735 2898042 YBL034C STU1
SGTC_3222 9128301 49.47 µM 0.346537578867672 0.364921902076701 no 1195 0.364469373891405 1680 4911358
SGTC_3146 9095609 49.47 µM 0.346236774914996 0.365039242940594 no 1196 0.36458238975084 1770 17173999
SGTC_3290 9121031 71.43 µM 0.345541568765552 0.365310484831037 no 1197 0.364843632541923 1672 17014854
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.344907402738806 0.365557970061106 no 1198 0.365081992574189 1670 6708760
SGTC_1264 0783-0040 158 µM 0.344728397127104 0.365627837683142 no 1199 0.365149283737778 1637 2855798
SGTC_344 k064-0035 6.43 µM 0.344394363769786 0.365758226054002 no 1200 0.36527486349224 1655 5088750
SGTC_1247 0448-0043 5.84 µM 0.344090852398943 0.365876713758476 no 1201 0.365388981041649 1718 3089013 YGL099W LSG1
SGTC_2329 6138490 200 µM 0.343670032608161 0.366041018624633 no 1202 0.365547225219982 1719 720019
SGTC_767 0929-0023 86 µM 0.34365680328226 0.366046184280703 no 1203 0.365552200318729 1701 1204563
SGTC_631 k072-0230 41.5 µM 0.342834288959971 0.366367399170662 no 1204 0.365861564321182 1756 5773147
SGTC_2879 9041815 71.43 µM 0.34235571672338 0.366554338148881 no 1205 0.366041605024442 1719 4942971
SGTC_3094 9117742 49.47 µM 0.341519790619443 0.366880941947596 no 1206 0.366356154363301 1656 17149698
SGTC_2479 5617353 43.85 µM 0.34115525957915 0.367023397676495 no 1207 0.36649335131749 1768 2731746
SGTC_2568 diosmetin 100 µM 0.339290634613348 0.367752363763259 no 1208 0.367195398583996 1817 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3274 9138298 49.47 µM 0.338890614564085 0.367908811846975 no 1209 0.367346067512623 1700 17015756
SGTC_1743 st037606 46.3785 µM 0.336978852543001 0.368656805365063 no 1210 0.368066420973717 1714 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3323 9138564 53.9225 µM 0.336962136450457 0.368663347881485 no 1211 0.368072721661445 1858 43912313 YNL103W MET4
SGTC_2970 9090938 41.86 µM 0.334468781556979 0.369639648147163 no 1212 0.369012922237823 1883 17217104
SGTC_1307 1187-1599 12.2 µM 0.333771538387079 0.369912812053714 no 1213 0.369275981026646 1711 1538471
SGTC_1609 st001574 46.4 µM 0.33303948924569 0.370199682788388 no 1214 0.369552237441397 1694 3960012
SGTC_1931 st074438 57.1 µM 0.332621519064522 0.370363506668121 no 1215 0.369709998796605 1693 2787313
SGTC_271 rotenone 740 µM 0.332059142142652 0.370583968033083 no 1216 0.369922300567887 1798 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_750 4073-0104 132 µM 0.331189007955368 0.370925159243937 no 1217 0.370250861272158 1720 22330957
SGTC_255 tunicamycin 200.472 nM 0.330884400420527 0.371044623918038 no 1218 0.370365902778803 1855 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_196 k015-0023 18.111 µM 0.329944837754394 0.371413191238549 no 1219 0.37072082158273 1722 5211998
SGTC_2127 5253358 187.912 µM 0.329423450776486 0.371617769427327 no 1220 0.370917822456706 1685 20612
SGTC_245 methotrexate 289.6 µM 0.328513207429434 0.37197501125854 no 1221 0.371261829913318 1788 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_97 0535-0701 19.132 µM 0.328497208081838 0.37198129148509 no 1222 0.371267877453314 1660 2832013 YGL099W LSG1
SGTC_1775 st081588 35.1725 µM 0.327713481889213 0.372288969323697 no 1223 0.37156415438605 1720 1426443 YGL099W LSG1
SGTC_841 0251-0215 91.2 µM 0.327057340308193 0.372546622290808 no 1224 0.371812258243232 1784 3888614
SGTC_2210 7115885 190.385 µM 0.325738535666139 0.373064661530994 no 1225 0.372311092867328 1763 2927039
SGTC_1042 0350-0096 82 µM 0.322763900133012 0.374233968839895 no 1226 0.373437027226392 1685 3122515
SGTC_1333 1482-0047 286 µM 0.32244693638839 0.37435863340414 no 1227 0.373557065631261 1849 3811116
SGTC_728 3030-5151 22.5 µM 0.321867949829605 0.374586387700111 no 1228 0.373776367243681 1764 3125388
SGTC_217 ketoconazole 989 nM 0.319772936953822 0.375410862071562 no 1229 0.374570232228585 1771 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3256 9138902 49.47 µM 0.319550242397086 0.375498535151388 no 1230 0.374654649399757 1827 17228773
SGTC_2979 9012552 45.46 µM 0.319244676834761 0.375618844352363 no 1231 0.374770490387676 1795 17100905
SGTC_1430 4049-0248 69.1 µM 0.316712946791779 0.376616117331274 no 1232 0.375730712019053 1857 22774488
SGTC_2704 st078022 71.1 µM 0.316409063171416 0.376735875550928 no 1233 0.375846019329474 1872 54697681
SGTC_1277 0873-0036 22 µM 0.316381800907012 0.376746619981646 no 1234 0.375856364418551 1834 5965735
SGTC_2143 5623677 140.463 µM 0.316202609199505 0.376817244256387 no 1235 0.375924363711717 1822 5375313
SGTC_73 0327-0325 16.231 µM 0.316155391516908 0.376835854702247 no 1236 0.375942282420319 1909 53298
SGTC_1201 1889-3372 45.9 µM 0.31401981389205 0.377677872924654 no 1237 0.376752995038399 1757 5392199
SGTC_2725 haloperidol 53.21 µM 0.313954194303511 0.377703754728732 no 1238 0.376777914318483 1749 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2101 5377231 179.231 µM 0.313228097777129 0.37799017974324 no 1239 0.377053686392562 1843 2844213
SGTC_905 2-aminofluorene 215 µM 0.307353540817899 0.380309984267227 no 1240 0.379287143409756 1736 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2746 daunorubicin 9.88 µM 0.307137905897628 0.380395218909758 no 1241 0.379369203213185 1881 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2114 5491910 81.25 µM 0.307010469862202 0.380445593652811 no 1242 0.379417701513076 1828 2849228
SGTC_2880 9042983 58.44 µM 0.305986092322253 0.380850597876912 no 1243 0.379807617484503 1759 6464714
SGTC_748 act1.228 77.9 µM 0.305548845822298 0.381023510142304 no 1244 0.379974086915707 1692 4421505 YNR035C ARC35
SGTC_330 1488-0319 80.1 µM 0.304649630276701 0.381379186023717 no 1245 0.380316508072122 1796 6846614
SGTC_1413 3910-0535 34.4 µM 0.304560329098094 0.381414513702984 no 1246 0.38035051907396 1850 2876951
SGTC_1942 st076330 65.2 µM 0.304241744908843 0.381540554130874 no 1247 0.380471861708926 1821 24208414
SGTC_175 3793-3120 23.7 µM 0.302275403127129 0.382318769120938 no 1248 0.381221063657163 1756 5322297
SGTC_992 3909-8734 162 µM 0.302011570975038 0.382423221676548 no 1249 0.381321621110001 1734 4288319
SGTC_2820 7989630 71.43 µM 0.301737349406745 0.382531796524747 no 1250 0.381426146895495 1931 2984098
SGTC_77 0828-0286 12.516 µM 0.299509139618466 0.383414372003218 no 1251 0.382275799756776 1808 745345
SGTC_1787 fluconazole 80 µM 0.299423922609414 0.383448137803011 no 1252 0.382308305682918 1785 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3284 9108171 64.8615 µM 0.298926453938599 0.383645269017566 no 1253 0.382498081059099 1787 8687505
SGTC_920 mycophenolic acid 780.421 nM 0.298103040524722 0.38397162806455 no 1254 0.38281226050736 1740 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1350 1495-0454 146 µM 0.297710982139363 0.384127048932818 no 1255 0.382961880386431 1866 1069057
SGTC_1788 fluconazole 20 µM 0.297671490999948 0.384142705152876 no 1256 0.382976952221256 1742 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_265 mycophenolic acid 32.932 µM 0.297415216756503 0.38424430939611 no 1257 0.383074763859961 1888 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2255 7941087 197.44 µM 0.296999174834329 0.384409273164994 no 1258 0.383233569558193 1908 935561
SGTC_1864 st057645 30.4 µM 0.296985245094014 0.384414796774778 no 1259 0.383238886963318 1881 688666
SGTC_1759 st043059 70 µM 0.295391898692365 0.385046766740709 no 1260 0.383847260628384 1705 669426
SGTC_2726 cimetidine 79.27 µM 0.293597449370012 0.385758865962261 no 1261 0.384532762519266 1849 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1731 st035964 63 µM 0.291139093291708 0.386735051125985 no 1262 0.385472471073174 1742 6739575
SGTC_282 k297-0036 65.7 µM 0.290953418544758 0.386808809651745 no 1263 0.385543472784123 1837 5061378
SGTC_76 0433-0009 400.328 µM 0.289347557104594 0.387446901797071 no 1264 0.386157711309194 1779 2841569
SGTC_790 1575-0012 79.1 µM 0.288167067480726 0.387916165724817 no 1265 0.386609428178286 1918 378741 YLR208W SEC13
SGTC_353 1988-1175 58.3 µM 0.287933769179784 0.388008925011992 no 1266 0.38669871847649 1741 2788357
SGTC_1868 st057644 42.7 µM 0.286402267046152 0.388618007922253 no 1267 0.387285019272263 1782 688665
SGTC_3262 9137218 49.47 µM 0.286113245100671 0.388732983573457 no 1268 0.387395693647468 1829 17650664
SGTC_2845 9003024 42.97 µM 0.285535639357081 0.388962789772611 no 1269 0.3876169020333 1882 2990173
SGTC_266 formosanin C 406 nM 0.285499577144667 0.38897713877251 no 1270 0.387630714159051 1863 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1588 farnesol 29.9 µM 0.285171567301697 0.389107659435167 no 1271 0.387756351170188 1782 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_556 4058-0063 51.5 µM 0.284282621102856 0.389461449034987 no 1272 0.388096901658778 1808 6615692
SGTC_2883 9059145 45.46 µM 0.284214705443819 0.389488482399452 no 1273 0.388122923323313 1766 16476510
SGTC_803 4488-1585 147 µM 0.283334234657819 0.389838996147042 no 1274 0.388460318276038 1895 747204
SGTC_2046 4110841 106 µM 0.283256854682467 0.389869805255916 no 1275 0.388489974182582 1929 44119630 YMR134W ERG29
SGTC_839 0122-0028 230 µM 0.280943306835143 0.390791271253457 no 1276 0.389376941844353 1837 759448
SGTC_1368 1852-0141 284 µM 0.280238943182109 0.391071935251009 no 1277 0.3896470954031 1810 2838987
SGTC_2069 5228469 200 µM 0.279706507681701 0.391284129625523 no 1278 0.389851342568729 1789 2835210
SGTC_2556 citropten 84.59 µM 0.279635979060411 0.391312240203684 no 1279 0.389878400280763 1715 2775 A potential DNA crosslinker.
SGTC_523 1934-0222 13.7 µM 0.278332656759009 0.391831807137269 no 1280 0.390378504830773 1772 1361595
SGTC_2642 cholecalciferol 100 µM 0.277578497998506 0.392132539278319 no 1281 0.390667969919167 1888 9821465 A vitamin D precursor, similar to steriods.
SGTC_2718 lomofungin 53.02 µM 0.27756446731663 0.392138134834774 no 1282 0.390673355822233 1924 5351222 A RNA synthesis inhibitor.
SGTC_456 gingerol 170 µM 0.277331845273641 0.392230909753448 no 1283 0.390762654593519 1847 442793 A herb.
SGTC_917 harmaline 728.087 nM 0.277108423465376 0.392320021178636 no 1284 0.390848427009703 1865 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3075 9116269 49.47 µM 0.27515886549562 0.393097838338002 no 1285 0.391597094067737 1834 17015205 YNL244C SUI1
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.274900670146341 0.393200882888429 no 1286 0.391696276136925 1917 16725076
SGTC_2810 7959871 45.46 µM 0.274341220996969 0.393424182077659 no 1287 0.391911204711283 1880 2974535
SGTC_1081 sertraline 6 µM 0.27381303221809 0.393635036144323 no 1288 0.392114153987292 1929 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_197 4544-0043 41.561 µM 0.273747887319889 0.393661044286211 no 1289 0.392139187053232 1835 896523
SGTC_1360 1598-0022 39.8 µM 0.272952874659092 0.393978479579443 no 1290 0.392444720503794 1896 761525
SGTC_2582 agaric acid 100 µM 0.272930573630401 0.393987385024981 no 1291 0.392453292028951 1759 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1170 0310-0127 64.8 µM 0.271811205972622 0.39443445202115 no 1292 0.392883594198266 1858 774975
SGTC_164 4100-3994 89.624 µM 0.271528971046661 0.394547196500275 no 1293 0.392992110340703 1969 4615967
SGTC_1404 3909-7820 48.3 µM 0.271423078117295 0.394589499863236 no 1294 0.393032827122381 1925 23741373
SGTC_1516 st013856 110 µM 0.271020304282031 0.394750416082602 no 1295 0.393187707964266 1843 5281404 A mutagen and neurotoxin.
SGTC_1991 st073000 8.92 µM 0.269820257811748 0.395229965056424 no 1296 0.393649268587794 1906 4301969 YIL048W NEO1
SGTC_432 NS 1619 61.3 µM 0.269765898097865 0.395251691432396 no 1297 0.393670179907815 1846 4552 A K+/calcium channel activator.
SGTC_163 TUB2.036 7.546 µM 0.269410034469529 0.395393930298388 no 1298 0.393807082575312 1925 15992207 YJR013W GPI14
SGTC_2475 5812728 15.03 µM 0.267814522236409 0.396031828381071 no 1299 0.394421045905346 1810 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1332 1480-0653 17.5 µM 0.267411087262112 0.396193168974184 no 1300 0.394576331889265 1969 5749438
SGTC_1893 st059353 36.1 µM 0.266627395557095 0.396506631578908 no 1301 0.394878030190348 1797 3112488
SGTC_1039 k821-0043 94 µM 0.265579044415634 0.396926057784438 no 1302 0.395281713155355 1939 15992768
SGTC_2154 5570129 200 µM 0.264707060112403 0.397275013704624 no 1303 0.395617569136699 1920 673366
SGTC_1513 0337-0559 19 µM 0.264397541535331 0.397398898501289 no 1304 0.395736802858581 1764 775073
SGTC_1928 4'-methoxychalcone 40.3 µM 0.264288957489167 0.397442361714054 no 1305 0.395778634259753 2017 641818
SGTC_1452 4194-0072 190 µM 0.263851211672801 0.397617592255944 no 1306 0.395947285576419 1971 1343545
SGTC_20 0481-0013 4.944 µM 0.262414662281382 0.39819279088016 no 1307 0.396500884896705 1789 182045
SGTC_2868 9035608 32.47 µM 0.262320923977753 0.398230331678975 no 1308 0.396537015850103 1793 6462614
SGTC_1120 ficusin 1.78878 µM 0.261973468745485 0.398369490555148 no 1309 0.396670948453612 1926 6199 A DNA cross-linker.
SGTC_1510 1123-0200 71.5 µM 0.261322250267157 0.398630344085248 no 1310 0.39692200465883 1934 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2496 diffractaic acid 79.83 µM 0.260045457231059 0.39914191051465 no 1311 0.397414354803821 1964 94870 An apoptosis inducer which activates caspases.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.258462523703143 0.399776377240114 no 1312 0.398024984138429 1848 16623 A steroid.
SGTC_914 3820-6779 408 µM 0.257958845008691 0.39997831583654 no 1313 0.398219334716551 1821 2893481
SGTC_3169 9102970 49.47 µM 0.257422015095629 0.400193575114196 no 1314 0.398426504897481 1894 17027839
SGTC_1687 st020778 55.3625 µM 0.254364149193904 0.401420301609245 no 1315 0.399607122534656 1878 4259299
SGTC_3329 9141233 27.5565 µM 0.254178407403648 0.401494847234035 no 1316 0.399678865658045 1940 4909101 YNL103W MET4
SGTC_1132 3456-3614 2.5 µM 0.252985540687776 0.401973677789724 no 1317 0.400139693347057 2014 3125502
SGTC_2675 theaflavin digallate 100 µM 0.252633009799519 0.402115215989318 no 1318 0.400275909562371 1886 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1220 1838-0075 193 µM 0.249959224218997 0.403189135136003 no 1319 0.401309441091886 1894 5529645
SGTC_311 1315-0136 58 µM 0.246495838931523 0.404581280035992 no 1320 0.402649212571219 1965 6759207
SGTC_1865 st057639 52.2 µM 0.245991553438314 0.404784084241529 no 1321 0.402844385511812 1946 688818
SGTC_997 3996-0078 137 µM 0.245857048139907 0.404838181416228 no 1322 0.40289644700998 1877 735687
SGTC_3326 9140064 16.379 µM 0.245476769102476 0.404991137060974 no 1323 0.403043646779188 1809 1868434
SGTC_957 1187-1561 14.1 µM 0.245361772923696 0.405037393626146 no 1324 0.403088162618115 1956 1538454
SGTC_2544 sphondin 68.51 µM 0.244831603253172 0.405250668538986 no 1325 0.403293411305048 1948 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1607 st000305 50.6 µM 0.244674971974309 0.405313683042708 no 1326 0.403354054284942 1966 5457690
SGTC_3140 9094243 49.47 µM 0.243929326007784 0.405613698328177 no 1327 0.403642778103731 2062 19291112
SGTC_168 3970-0862 530.542 µM 0.243816394177795 0.405659141991194 no 1328 0.403686511360739 1888 3135186
SGTC_770 0389-1121 67.2 µM 0.24363698795695 0.405731337501297 no 1329 0.403755989540321 1982 6753108
SGTC_62 0180-0423 3.232 µM 0.240928665191268 0.406821591752439 no 1330 0.404805202407486 1931 30102 YGL099W LSG1
SGTC_2945 9067681 61.76 µM 0.238787470332106 0.407684056593873 no 1331 0.405635193225439 1927 16456930
SGTC_2107 5363541 170.161 µM 0.238573428903709 0.40777029631408 no 1332 0.405718185445849 1943 244052
SGTC_2447 5741742 33.78 µM 0.238412142893653 0.407835283230491 no 1333 0.405780725130536 1921 1776504
SGTC_2199 6590217 200 µM 0.238093513181162 0.407963676042534 no 1334 0.405904282911714 1957 703109
SGTC_3026 9090633 49.47 µM 0.237377648844428 0.408252171783183 no 1335 0.406181913946339 1852 25236842
SGTC_1986 st071812 45 µM 0.236357251569841 0.408663481267411 no 1336 0.406577732396405 1905 11838594
SGTC_2695 st077686 51.995 µM 0.236182785068637 0.408733816635132 no 1337 0.406645418605826 1842 2876092
SGTC_874 0599-0792 117 µM 0.235213452350078 0.409124652137485 no 1338 0.407021532701762 2034 765305
SGTC_884 0851-0618 334 µM 0.23518274000151 0.409137036852724 no 1339 0.407033450908415 1997 9642473
SGTC_1176 0848-0131 83.3 µM 0.234909249215372 0.409247325660731 no 1340 0.407139585294739 2027 6769040
SGTC_1164 k060-0068 93.7 µM 0.234374003475901 0.409463191425664 no 1341 0.407347319432162 1916 5963676
SGTC_2036 5160441 105 µM 0.232598492692904 0.410179454992557 no 1342 0.40803659893563 1922 134534 YIL048W NEO1
SGTC_1508 1080-0625 72.9 µM 0.231936072323714 0.410446760679262 no 1343 0.408293833342305 1964 767111
SGTC_524 r073-0010 27.8 µM 0.231930169412193 0.410449142861191 no 1344 0.408296125768402 1835 2772106
SGTC_844 0330-0132 15.3 µM 0.231503084717123 0.410621506136264 no 1345 0.408461994633129 1983 2828079
SGTC_706 4262-0057 46.9 µM 0.230374682264959 0.411076990918513 no 1346 0.408900316363465 1863 883298
SGTC_2823 7987624 58.44 µM 0.22916026158876 0.411567331305949 no 1347 0.409372178705758 1907 2239440
SGTC_2128 5255449 168.493 µM 0.228995363743853 0.411633921929775 no 1348 0.409436259795205 1883 736008
SGTC_1256 0570-0116 285 µM 0.228887561680039 0.411677456965586 no 1349 0.409478154153577 1832 410638
SGTC_3184 9108758 49.47 µM 0.228555240505933 0.411811669160394 no 1350 0.409607308298896 1909 902885
SGTC_2171 5739187 198.077 µM 0.228365696188369 0.41188822370076 no 1351 0.409680977678216 1859 2262761
SGTC_717 1532-0246 73.2 µM 0.224266637989477 0.413544596942907 no 1352 0.411274917040715 1898 9561992
SGTC_1269 0831-0796 3.05 µM 0.224199008942268 0.413571937905426 no 1353 0.411301227297902 1994 927758
SGTC_2399 5884133 200 µM 0.224052001672968 0.413631371213299 no 1354 0.411358420061591 1854 722445
SGTC_1962 st076595 64.5 µM 0.222624153495796 0.414208736162346 no 1355 0.411914018197831 1898 279619
SGTC_146 3448-8650 53.125 µM 0.221599291148751 0.414623264090501 no 1356 0.412312917178511 1926 2891488 YIL048W NEO1
SGTC_1239 0337-0584 35.4 µM 0.221191880928485 0.414788076481274 no 1357 0.412471515392416 2031 914301 YML130C ERO1
SGTC_2380 9035439 200 µM 0.21961074766681 0.415427844749317 no 1358 0.41308716015998 1988 6462575
SGTC_1719 st032227 49.2 µM 0.219489622978301 0.415476864266534 no 1359 0.413134331231956 1841 3125804
SGTC_138 0850-0259 40.9225 µM 0.219245940732045 0.415575487172088 no 1360 0.413229235194505 2013 6813004
SGTC_3300 9124615 50.48 µM 0.217295369879505 0.416365111983617 no 1361 0.41398908259929 1989 24824903
SGTC_1193 1488-0126 41.5 µM 0.215949472992706 0.416910151386265 no 1362 0.414513566460897 1899 1384710
SGTC_3083 9117465 49.47 µM 0.215107886140501 0.417251044766196 no 1363 0.414841602786906 1852 16420915
SGTC_535 2293-4129 48.2 µM 0.214709233999066 0.417412544632111 no 1364 0.414997011394533 2031 396118 YIL048W NEO1
SGTC_103 0844-0104 51.839 µM 0.214551746196997 0.417476349105889 no 1365 0.415058409338594 2008 5375804
SGTC_1690 st023502 41.2 µM 0.21437260274262 0.417548929773676 no 1366 0.415128252442899 2028 24207482
SGTC_80 0159-0065 512.242 µM 0.214154114717088 0.417637454849683 no 1367 0.415213438543448 2040 1548079
SGTC_1959 st077091 55.8 µM 0.21370756846627 0.417818395550888 no 1368 0.415387554455141 1901 821356 YKL052C ASK1
SGTC_922 1866-0035 480 µM 0.212514017065826 0.418302108307806 no 1369 0.41585302174107 1907 3156169
SGTC_2927 9011802 47.9 µM 0.211139203186086 0.418859434765547 no 1370 0.416389324996397 1846 43912568
SGTC_1142 3253-1408 9.78 µM 0.210814642787799 0.41899102990726 no 1371 0.416515956013136 2055 256655
SGTC_880 0833-0487 87.2 µM 0.21038402249332 0.419165641717782 no 1372 0.416683980905032 1884 76075
SGTC_1084 voriconazole 435 nM 0.209825038737167 0.419392327249576 no 1373 0.416902114983251 2061 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_700 3453-2283 142 µM 0.209300077906647 0.419605239777324 no 1374 0.417106995481576 1999 565664
SGTC_2089 5281248 129.67 µM 0.208547969180825 0.419910319481986 no 1375 0.417400565952601 1904 2737878
SGTC_2802 7925815 54.55 µM 0.207973097419058 0.420143538589823 no 1376 0.417624986609128 1903 1262923
SGTC_1669 st015249 58.4 µM 0.207907907835172 0.420169987053915 no 1377 0.417650437265673 2084 722793
SGTC_1761 st044296 37 µM 0.207132969596846 0.420484419559185 no 1378 0.417953007191436 1935 1826700
SGTC_878 0828-0289 13.7 µM 0.206709680390566 0.420656191315249 no 1379 0.41811829841187 1894 745350 YLR208W SEC13
SGTC_883 0850-0245 24.6 µM 0.205548811243808 0.42112735218935 no 1380 0.418571683137061 2027 6823229 YPR165W RHO1
SGTC_2348 9022543 33.42 µM 0.205353710956432 0.421206548467959 no 1381 0.418647891413809 1946 3162678 YDL140C RPO21
SGTC_793 0488-0545 106 µM 0.205292633464806 0.421231342065024 no 1382 0.418671749568547 1884 292548
SGTC_2 0422-0095 29 µM 0.205049074150402 0.421330214841365 no 1383 0.418766891941143 1965 6790840
SGTC_2797 7859098 81.82 µM 0.204971477984249 0.421361716006762 no 1384 0.418797204583974 1927 972681
SGTC_516 3992-2719 87.3 µM 0.203798489298131 0.421837967108544 no 1385 0.419255486716548 1829 5350887 YDR037W KRS1
SGTC_1878 temozolomide 1 mM 0.203525556821481 0.421948798234087 no 1386 0.41936213611242 2086 5394 DNA alkylating agent.
SGTC_1745 st081495 74 µM 0.203284851655825 0.422046547776447 no 1387 0.419456197481468 1944 13842402 YBL026W LSM2
SGTC_1183 1254-0324 198 µM 0.201873933446408 0.422619613207741 no 1388 0.420007640308879 2008 5799357
SGTC_765 1319-0117 244 µM 0.201533798350717 0.422757788690984 no 1389 0.420140602141781 1975 3487746 YGL099W LSG1
SGTC_2166 5933061 31.504 µM 0.200099047323594 0.42334074214122 no 1390 0.420701559212336 2023 2877375
SGTC_453 enantio-paf c16 10 µM 0.199901023996411 0.423421214177304 no 1391 0.420778994786994 2015 13871343 A lipid and platelet activating factor
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.199660719224358 0.423518872690992 no 1392 0.420872968328323 2036 6728940
SGTC_580 1123-0028 41 µM 0.198860041694531 0.423844297429528 no 1393 0.421186113651177 2038 1677248 YPR107C YTH1
SGTC_1290 0986-0249 10.2 µM 0.19846796026985 0.424003672671756 no 1394 0.421339475062633 2058 53329
SGTC_2580 diallyl disulphide 81.36 µM 0.197568488493455 0.42436934143831 no 1395 0.421691345665217 1916 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2290 7904846 200 µM 0.195493108059278 0.425213308781466 no 1396 0.422503466284103 1918 2962154
SGTC_2891 9063876 19.48 µM 0.195426105981464 0.425240561358354 no 1397 0.422529690489876 2116 6472478
SGTC_204 PMA1.184 62.41 µM 0.19537163786874 0.425262716105139 no 1398 0.42255100923098 2009 2252213 YGL008C PMA1
SGTC_2619 obliquin 87.91 µM 0.193989826610967 0.425824842579986 no 1399 0.423091923890014 2018 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2153 5569715 200 µM 0.192223108897177 0.4265437700549 no 1400 0.423783722572964 1998 2054701
SGTC_2178 5812956 200 µM 0.191233261633006 0.426946673804782 no 1401 0.424171422722962 2070 5403383
SGTC_885 0865-0106 16.8 µM 0.190709739689497 0.427159797076052 no 1402 0.424376503789012 1925 2793380
SGTC_321 4534-3890 65.3 µM 0.189888796163572 0.427494042036157 no 1403 0.424698136052542 2074 699746
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.188277397548127 0.428150269803728 no 1404 0.425329601319759 1934 75037 A free radical scavenger.
SGTC_2742 clothiapine 36.27 µM 0.187744004964019 0.428367533066769 no 1405 0.425538666307981 2087 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3258 9138477 49.47 µM 0.18727959283341 0.428556716664777 no 1406 0.425720711231889 1997 4970355
SGTC_1154 4088-0362 150 µM 0.186891980301981 0.428714627638778 no 1407 0.425872663603231 2058 6618304
SGTC_1693 xanthone 101.9 µM 0.186063350444017 0.429052244618474 no 1408 0.426197541055918 2029 7020 An insecticide.
SGTC_3176 9106582 49.47 µM 0.185807542593827 0.429156481476578 no 1409 0.426297844702041 2082 17018027
SGTC_2661 dactinomycin 12.96 µM 0.184026587240672 0.429882323619621 no 1410 0.426996298752431 2047 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_449 xestospongin c 11.1929 µM 0.182239364546427 0.430610958380415 no 1411 0.427697440883477 2038 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_948 3448-0295 75.3 µM 0.182155373573777 0.430645206583835 no 1412 0.427730396867396 1996 678569
SGTC_1123 mangostin 811.285 nM 0.182129774707917 0.430655644894647 no 1413 0.427740441330585 1932 5281650 An antioxidant.
SGTC_268 camptothecin 39.6153 µM 0.181729552556969 0.43081884760785 no 1414 0.427897486274193 2078 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_19 0279-0214 38.434 µM 0.181473644135747 0.430923208217977 no 1415 0.42799790930232 2032 3566274 YBR002C RER2
SGTC_482 fipronil 114 µM 0.18113614338019 0.43106084992507 no 1416 0.428130357747794 2096 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1227 3909-8010 46.6 µM 0.180606956407897 0.431276683176851 no 1417 0.428338047628906 1999 15982272
SGTC_987 1497-1013 404 µM 0.180448082661736 0.43134148514719 no 1418 0.428400404646076 2058 1676435
SGTC_751 0833-0568 350 µM 0.176359212045205 0.433009898754192 no 1419 0.430005873220571 1986 6954252
SGTC_2446 5162541 200 µM 0.175039349029141 0.433548709224504 no 1420 0.430524357398617 1955 1549321
SGTC_3036 9090181 49.47 µM 0.174523531023255 0.433759316325235 no 1421 0.430727019725904 2005 25236586
SGTC_1072 oxiconazole 14.9 nM 0.173422916691137 0.434208756994631 no 1422 0.431159506550772 2071 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2219 9098279 200 µM 0.168987652790354 0.436020772570192 no 1423 0.432903176685253 2096 902349
SGTC_819 1013-0258 27.7 µM 0.16792229817067 0.436456222026473 no 1424 0.433322203904583 2003 5753198
SGTC_104 0074-0074 590.992 µM 0.165061576790685 0.437625883287253 no 1425 0.434447757699211 2119 3943124
SGTC_501 nsc-95397 161 µM 0.164414794279009 0.437890408766686 no 1426 0.434702308952546 2093 262093
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.163856849636615 0.43811862303969 no 1427 0.434921918441841 2038 1377
SGTC_1387 3342-1166 1.8 µM 0.163411874559383 0.438300644497183 no 1428 0.435097077003605 2026 3418228
SGTC_1937 st074714 47.2 µM 0.161582485048593 0.439049111106869 no 1429 0.435817325476578 1935 17250970
SGTC_2789 5281112 71.43 µM 0.161556291310163 0.439059829461746 no 1430 0.435827639758448 1964 765948
SGTC_2767 sibutramine 71.45 µM 0.160636979015996 0.439436035988048 no 1431 0.436189664028437 2129 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2995 9067767 71.4286 µM 0.160587252273606 0.439456387028321 no 1432 0.436209247897208 2018 11673567
SGTC_2971 9092186 9.93 µM 0.159881532733368 0.439745225238726 no 1433 0.436487198058888 1859 25236400
SGTC_672 1441-0018 53.7 µM 0.159797051173673 0.439779804161855 no 1434 0.436520473527559 2004 251141
SGTC_43 0570-0105 72.5 µM 0.159641486831391 0.439843478991843 no 1435 0.436581748149906 2046 1114046 YDL195W SEC31
SGTC_3043 9092303 49.47 µM 0.159426062976993 0.43993165779148 no 1436 0.436666603110705 1982 25236084
SGTC_317 4495-0002 170 µM 0.157923230677716 0.440546890287638 no 1437 0.437258646165236 1992 15991618
SGTC_2407 paclitaxel 400 µM 0.157129770005676 0.440871776803815 no 1438 0.437571287962701 2040 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.1554675924594 0.441552492636777 no 1439 0.438226350371825 2102 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2943 9068529 45.32 µM 0.15491187952481 0.441780113794889 no 1440 0.438445394100322 2117 3270634
SGTC_1682 st012968 530 nM 0.151592253203159 0.443140237475028 no 1441 0.439754271919304 1960 24207270
SGTC_1933 st074711 15.9 µM 0.151124634646473 0.44333188527531 no 1442 0.439938700018706 2149 17250958
SGTC_747 3448-8087 38.7 µM 0.150258207132052 0.443687015099023 no 1443 0.440280452226699 2021 5168703
SGTC_639 0833-0042 114 µM 0.149574888474147 0.443967124494276 no 1444 0.440550010681867 1992 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_904 1141-0088 396 µM 0.148550912589884 0.444386930164472 no 1445 0.440954004592322 1959 1378119
SGTC_2400 5203494 178.7 µM 0.148113477006269 0.444566287361214 no 1446 0.441126606821957 2132 6777674
SGTC_1792 st045773 43.6 µM 0.147653224977178 0.444755012003683 no 1447 0.441308223979976 2019 2919270
SGTC_1074 carmofur 3.8 µM 0.145300797292157 0.445719810968379 no 1448 0.442236692629082 2148 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1323 1348-1351 11.2 µM 0.145242089974635 0.44574389268131 no 1449 0.442259867625323 1996 6989654
SGTC_194 1486-1323 56.904 µM 0.145021740694636 0.445834281633056 no 1450 0.442346853326611 2006 5178754
SGTC_161 4065-0411 162.148 µM 0.14466154651743 0.445982042086164 no 1451 0.442489050576552 2057 1906281 YLR208W SEC13
SGTC_3060 1327-0027 12.5 µM 0.144342187523448 0.446113057224644 no 1452 0.442615133134079 2159 16000455 YPR107C YTH1
SGTC_2567 aureobasidin a 60 nM 0.143974804595727 0.44626378117422 no 1453 0.442760182672618 2042 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_93 0109-0045 59.227 µM 0.143847530929821 0.446315998775654 no 1454 0.442810434447723 2173 88733
SGTC_2493 resveratrol 26.09 µM 0.142535294256554 0.446854434902439 no 1455 0.443328601585824 2064 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2464 5717415 7.67 µM 0.142476102926859 0.446878724568595 no 1456 0.443351976948787 1981 5285744
SGTC_1145 3546-0597 10.2 µM 0.141717137082478 0.447190190293173 no 1457 0.443651719065535 2062 875334
SGTC_2382 9035899 200 µM 0.140465008171434 0.447704112244008 no 1458 0.444146298892571 2014 6462679
SGTC_614 0462-0418 107 µM 0.140090209839302 0.447857961034419 no 1459 0.444294357865124 2129 5188303
SGTC_26 0302-0163 425.158 µM 0.13986864331919 0.447948914279082 no 1460 0.444381888356523 2064 3100915
SGTC_2467 5474540 200 µM 0.139401650553683 0.448140624162654 no 1461 0.444566384071266 2145 5413519
SGTC_2252 omeprazole 400 µM 0.138469118847334 0.448523483305644 no 1462 0.44493483703578 2109 4594 A proton pump inhibitor.
SGTC_1638 st008370 60.6 µM 0.138376778146998 0.448561397211947 no 1463 0.444971324399875 2154 24207134
SGTC_1085 doxorubicin 7.67 µM 0.138273417679017 0.448603836250621 no 1464 0.445012166651218 2169 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1186 1319-0216 26 µM 0.138200671597039 0.448633705602978 no 1465 0.44504091216679 2188 4565136
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.137785585974847 0.448804144247098 no 1466 0.445204938211667 2140 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_806 3966-4455 5.86 µM 0.137195913553132 0.449046286356696 no 1467 0.445437970440395 1997 714982
SGTC_3010 9080089 71.4286 µM 0.136289451030178 0.449418551611617 no 1468 0.445796231464875 2167 17027233
SGTC_2854 9024559 71.43 µM 0.135724304551706 0.449650668038994 no 1469 0.446019616627849 2041 3163529
SGTC_424 splitomicin 100 mM 0.13521819758424 0.449858550439503 no 1470 0.446219679818817 1962 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2094 5332512 191.667 µM 0.134371256284264 0.450206460597295 no 1471 0.446554504822089 2161 755774
SGTC_1807 st050092 58.9 µM 0.134151513843262 0.450296733597552 no 1472 0.446641382796651 2074 5008496
SGTC_3066 9117245 49.47 µM 0.132646618302736 0.45091503276906 no 1473 0.447236431040991 2114 17176980
SGTC_1048 3161-0300 24.5 µM 0.132439654877028 0.451000074809789 no 1474 0.447318275427088 2140 2165101
SGTC_3132 9126706 49.47 µM 0.13220338647073 0.451097161125275 no 1475 0.447411711308961 2101 850858
SGTC_572 0960-0087 17.7 µM 0.130946127166472 0.451613837341538 no 1476 0.447908962304223 2108 6796365
SGTC_405 ebelactone b 50 µM 0.13085211175751 0.451652476690452 no 1477 0.447946149067448 2042 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_927 2425-1185 123 µM 0.13032616602535 0.451868643318721 no 1478 0.448154189558751 2056 730375
SGTC_1629 st005085 44.9 µM 0.130265889182197 0.451893418350005 no 1479 0.448178033280459 2047 24207091
SGTC_848 0368-0089 85.6 µM 0.129771881184479 0.452096472922351 no 1480 0.448373455160369 2171 762535
SGTC_1386 3228-0095 33.8 µM 0.129315995497774 0.45228386901017 no 1481 0.448553807563727 2143 870181
SGTC_1440 4100-1550 40 µM 0.129198056043064 0.452332350861794 no 1482 0.448600467186127 2152 742806
SGTC_766 1391-0721 126 µM 0.128788978495772 0.452500517537521 no 1483 0.448762313391772 2173 1020919 YIL115C NUP159
SGTC_1441 4106-0040 13 µM 0.126783103371628 0.453325230540297 no 1484 0.449556034683115 2183 2904180
SGTC_517 1365-0151 113 µM 0.125735448000001 0.45375605298088 no 1485 0.449970670541916 2083 768657
SGTC_596 1155-0152 116 µM 0.125528446957619 0.45384118351072 no 1486 0.450052602866851 2118 280313
SGTC_2340 7987427 183.45 µM 0.122561748375533 0.45506148878314 no 1487 0.451227073191712 2119 2239331
SGTC_956 1185-0240 191 µM 0.122236028508684 0.455195494629546 no 1488 0.451356046881226 2098 1416193
SGTC_2317 5986382 200 µM 0.120270734328827 0.456004152619442 no 1489 0.452134343212297 2154 877883
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.119656686018219 0.456256852107062 no 1490 0.452377556652427 2071 688803
SGTC_3096 9117468 49.47 µM 0.118777253732955 0.456618795933857 no 1491 0.452725914991852 2205 41316311
SGTC_2206 7254556 146.969 µM 0.118114009405534 0.456891788121392 no 1492 0.452988661627472 2194 4398905
SGTC_1475 4092-1048 11.7 µM 0.117742153193038 0.457044853508871 no 1493 0.453135982821854 2100 2881759
SGTC_771 0250-0039 27.3 µM 0.117559674306122 0.457119968749409 no 1494 0.453208279275315 2078 3005115
SGTC_1345 1488-0192 31.4 µM 0.117506281719695 0.457141947455698 no 1495 0.453229433219441 2181 658348
SGTC_636 0kpi-0074 126 µM 0.114837070474831 0.458240876372104 no 1496 0.454287132712046 2092 616434
SGTC_2702 st077768 96.8 µM 0.114481476735126 0.458387300548983 no 1497 0.454428064638923 2079 6484119
SGTC_1976 st070609 63.5 µM 0.114063693994061 0.458559339738903 no 1498 0.454593651167078 2191 682556
SGTC_421 streptovitacin 30 mM 0.113645327170366 0.458731627227842 no 1499 0.454759477101626 2078 91467 include heat shock
SGTC_1565 sinapyl alcohol 95.1 µM 0.113245075907112 0.458896461810971 no 1500 0.454918130043553 2086 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1351 1496-0003 46.5 µM 0.11242216073973 0.459235383296485 no 1501 0.455244342489659 2197 3891978
SGTC_2795 7780010 54.55 µM 0.112176434747953 0.459336592458834 no 1502 0.455341756783972 2118 953673
SGTC_2821 7996764 71.43 µM 0.111237710348081 0.459723256718972 no 1503 0.45571392432343 2142 2987135
SGTC_2754 granisetron 64.02 µM 0.110442009564884 0.460051038838739 no 1504 0.45602941903448 2189 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1259 0671-0132 43 µM 0.110191648252281 0.460154178662372 no 1505 0.456128692834325 2106 X1259
SGTC_1583 clindamycin 39.6 µM 0.109848866356707 0.460295396777235 no 1506 0.456264617880862 2034 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_3206 9114350 49.47 µM 0.109332056163101 0.460508319938269 no 1507 0.456469560923131 2219 17087243
SGTC_208 k072-0098 12.366 µM 0.109310449502121 0.460517222019308 no 1508 0.456478129379058 2236 5948901
SGTC_2336 9001819 198.65 µM 0.108587869372835 0.460814940973743 no 1509 0.456764691346797 2172 2989602
SGTC_2068 5226020 147 µM 0.107173656537458 0.461397691274039 no 1510 0.457325607037413 2142 1810509
SGTC_655 k060-0012 42 µM 0.107019599334391 0.461461178177635 no 1511 0.457386715514875 2126 5994525
SGTC_1007 4101-0031 70 µM 0.105143541975228 0.462234378886522 no 1512 0.458130954631362 2224 1146276
SGTC_3135 9127742 49.47 µM 0.103129549086803 0.463064587310944 no 1513 0.45893007663679 2073 3643468
SGTC_1781 st038725 66.3 µM 0.102082116169701 0.463496424081453 no 1514 0.459345748039964 2036 4270275 YIL048W NEO1
SGTC_378 3970-0959 8.33 µM 0.102047386863738 0.463510743056665 no 1515 0.459359531050908 2148 6615653
SGTC_2109 5483026 200 µM 0.0999958603066838 0.464356675560722 no 1516 0.460173805985119 2136 759335
SGTC_454 lyso-paf C-16 6.67 µM 0.0986592359981222 0.464907910103034 no 1517 0.460704417930253 2116 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2293 7624732 200 µM 0.0973514298292029 0.465447325012669 no 1518 0.461223657411889 2227 894453
SGTC_1298 1079-1278 263 µM 0.0970780108024497 0.465560106892089 no 1519 0.461332221603714 2166 2840950
SGTC_2990 9074105 71.4286 µM 0.0967372463420994 0.465700671779567 no 1520 0.461467530112876 2247 6502001
SGTC_1466 k213-0079 57.5 µM 0.0963492193986368 0.465860737588395 no 1521 0.461621610728234 2164 3657981
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.0959703299874554 0.466017039384196 no 1522 0.461772068503403 2145 2724 A muscle relaxant with antifungal properties.
SGTC_69 0096-0274 206.684 µM 0.095322379935086 0.466284347868592 no 1523 0.462029383486745 2182 6741392
SGTC_1393 3470-5649 58.2 µM 0.0946928556403202 0.466544069469427 no 1524 0.462279396425915 2162 4108395
SGTC_369 0957-0393 4.5 µM 0.0939652380223408 0.466844278983034 no 1525 0.46256838528011 2141 6997992
SGTC_1901 st060216 58.6 µM 0.0934147224408916 0.467071430083133 no 1526 0.462787047422117 2238 688792
SGTC_2830 7992007 71.43 µM 0.0929308137981164 0.467271107006668 no 1527 0.462979262897248 2181 1952075
SGTC_2006 4011487 200 µM 0.0928150923980034 0.467318858756809 no 1528 0.46302523038473 2220 45595294
SGTC_1861 st057647 17.4 µM 0.0927175365925989 0.467359114947329 no 1529 0.463063982418904 2231 688668
SGTC_786 4544-0069 423 µM 0.0925466980931696 0.467429611885825 no 1530 0.463131845337903 2163 748821 YLR208W SEC13
SGTC_599 1935-0052 86.5 µM 0.092089932021355 0.467618102570777 no 1531 0.463313293772149 2244 9557311
SGTC_938 3126-1755 342 µM 0.0920856073088209 0.467619887256544 no 1532 0.463315011782864 2242 1777771
SGTC_1453 4237-0541 195 µM 0.0920005736922243 0.467654978341947 no 1533 0.463348791892904 2252 739892
SGTC_2066 5222451 176 µM 0.0918048301600238 0.46773575738526 no 1534 0.46342655317945 2240 2281147
SGTC_294 k038-0071 157 µM 0.0912076695368128 0.467982200613808 no 1535 0.463663790473985 2152 24152826
SGTC_1827 berberine 7.24 µM 0.0911012707952251 0.468026111781318 no 1536 0.463706061447588 2105 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2997 9067075 71.4286 µM 0.0904995568985286 0.468274448713031 no 1537 0.463945123026702 2181 27209819
SGTC_3282 9108498 15.4605 µM 0.0886968254285674 0.469018538291833 no 1538 0.464661427767122 2157 16459645
SGTC_2258 7960471 200 µM 0.0871504323036147 0.469656908825873 no 1539 0.465275969332514 2094 2974708
SGTC_287 k060-0039 29.6 µM 0.0869896468352111 0.469723287594621 no 1540 0.465339870769672 2253 5861974
SGTC_693 4161-2696 114 µM 0.086944631437075 0.469741871929303 no 1541 0.465357761530721 2209 805759
SGTC_551 k048-0028 34.9 µM 0.0865335177817304 0.469911600758637 no 1542 0.465521156327135 2236 6836383
SGTC_2029 5175081 200 µM 0.0861490040522258 0.470070352721076 no 1543 0.465673984394949 2245 1380876
SGTC_1567 st069303 68.4 µM 0.0848741281844539 0.470596737252885 no 1544 0.466180730135485 2148 5581319
SGTC_2982 9019404 25.97 µM 0.0834606632919346 0.47118040394324 no 1545 0.4667426271857 2100 22333232
SGTC_60 0986-0278 202 µM 0.0833063218492004 0.471244140432617 no 1546 0.466803986830677 2025 3110598
SGTC_2072 5231554 129 µM 0.083161969520471 0.471303752506917 no 1547 0.466861375939464 2270 789545
SGTC_2377 9073351 62.6 µM 0.0830547725282774 0.471348021242881 no 1548 0.466903993916312 2150 7337946 YHR072W ERG7
SGTC_1559 coumarin 343 70.1 µM 0.0826504609556329 0.471514991443256 no 1549 0.467064738228917 2226 108770 A hepatotoxic, DNA x-linker.
SGTC_393 acivicin 6.25 µM 0.0824772005677596 0.471586545027043 no 1550 0.467133623932934 2195 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1680 diphenhydramine 100 µM 0.0824434271783276 0.471600492967477 no 1551 0.467147051835359 2102 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1414 3917-0015 5.4 µM 0.0823262309320764 0.471648893658362 no 1552 0.467193647974389 2244 6618702
SGTC_820 1582-0060 59.9 µM 0.0817948852132033 0.47186833852177 no 1553 0.467404911727631 2175 3848840
SGTC_1237 0330-0133 46.1 µM 0.0816331117609102 0.471935152376942 no 1554 0.467469234890062 2222 X1237 YHR072W ERG7
SGTC_3212 9128307 49.47 µM 0.0813513361460563 0.472051530062916 no 1555 0.467581274451318 1991 27243542
SGTC_302 1094-0063 18.9 µM 0.0799096855895411 0.472646991157862 no 1556 0.468154543240092 2213 5440289
SGTC_1077 5-fluorocytosine 377 nM 0.0791506908383417 0.472960511921124 no 1557 0.468456382245176 2203 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3082 9117008 49.47 µM 0.0789853676340475 0.473028804815857 no 1558 0.468522130817747 2146 41448529
SGTC_2481 5478948 45.16 µM 0.0785727344113319 0.473199261760843 no 1559 0.46868623762968 2164 77792
SGTC_1160 4092-0570 10.5 µM 0.0783924703106253 0.473273729599457 no 1560 0.468757931460886 2211 4994975
SGTC_810 3825-7150 143 µM 0.0771511758865464 0.473786538634124 no 1561 0.469251640907429 2277 22330411 YGL099W LSG1
SGTC_3350 9150499 3.57 µM 0.0768541091769185 0.473909270619308 no 1562 0.46936980254355 2280 4910996 YPR165W RHO1
SGTC_1236 0330-0013 258 µM 0.0768469518600156 0.473912227668259 no 1563 0.469372649480441 2192 4617066
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.0752640583999236 0.474566235886874 no 1564 0.470002308792217 2226 5393153
SGTC_1909 st060837 51.5 µM 0.0750643042077903 0.474648773754618 no 1565 0.470081774391087 2191 678937
SGTC_519 k048-0011 62.8 µM 0.0749682253789749 0.474688473642949 no 1566 0.4701199966001 2166 6836379
SGTC_838 0109-0203 71.4 µM 0.0748388928012473 0.474741914417368 no 1567 0.470171448294935 2281 759422
SGTC_2822 7994718 71.43 µM 0.0743611070613429 0.474939341462165 no 1568 0.47036152757839 2276 1018011
SGTC_2684 capsaicin 100 µM 0.0728977569591015 0.475544054110924 no 1569 0.470943739441907 2221 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3319 9138450 16.7555 µM 0.0727941245607377 0.47558688116358 no 1570 0.470984973237738 2151 2029690
SGTC_2358 9037157 4 µM 0.0723739429732972 0.475760527998301 no 1571 0.471152160448554 2213 2388925
SGTC_1401 3807-4679 7.6 µM 0.0721438973429712 0.475855600026895 no 1572 0.47124369609461 2274 3291456
SGTC_2274 7947094 46.08 µM 0.0713891192609939 0.476167540303386 no 1573 0.471544034543645 2284 2971028
SGTC_3314 9135860 59.4275 µM 0.0712204768976893 0.476237240071587 no 1574 0.471611142295061 2264 25252478
SGTC_2271 7849410 118.62 µM 0.0699663465751433 0.476755593902186 no 1575 0.472110222756422 2307 972430
SGTC_2529 gangaleoidin 93.61 µM 0.0692159891517094 0.47706574851269 no 1576 0.472408848064026 2250 4565183
SGTC_697 0508-1955 564 µM 0.0692068188607863 0.477069539069946 no 1577 0.472412497728976 2268 6243113
SGTC_715 0868-0130 184 µM 0.0690002463269139 0.477154926770209 no 1578 0.472494711713882 2279 2876258
SGTC_2195 6536160 144.242 µM 0.0684228260838544 0.477393611615752 no 1579 0.472724525910342 2268 3834386
SGTC_2674 ligustilide 100 µM 0.0680965843931836 0.477528471835719 no 1580 0.472854374653361 2242 5319022 A signalling regulator.
SGTC_308 4092-1169 104 µM 0.0669465591644596 0.478003884150957 no 1581 0.473312123649148 2249 2268590 YDL196W YDL196W
SGTC_1096 rimcazole 32.2 µM 0.0669373438334293 0.478007693831106 no 1582 0.473315791806191 2245 18528119 A dopamine reuptake inhibitor.
SGTC_1530 rhein 70.4 µM 0.0669133692916924 0.478017605078154 no 1583 0.473325334868889 2277 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_487 nimodipine 119 µM 0.0667916854560692 0.47806791025572 no 1584 0.47337377133711 2298 4497 L-type voltage-gated calcium channels inhibitor
SGTC_989 1501-0895 10.3 µM 0.0645543273009914 0.47899291542553 no 1585 0.474264425173825 2307 2830112
SGTC_3059 1327-0034 3 µM 0.0643174532122239 0.47909085449334 no 1586 0.474358728286888 2239 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1282 0886-0010 32.4 µM 0.0642673342541252 0.479111577074015 no 1587 0.474378681577096 2286 2836211 YNL267W PIK1
SGTC_830 4076-0286 57.8 µM 0.0642038902197565 0.479137809227048 no 1588 0.474403939920385 2250 6866659
SGTC_2234 tolnaftate 200 µM 0.064002512906201 0.479221073138362 no 1589 0.474484112951274 2294 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2952 9073731 13.78 µM 0.0630226721337953 0.479626222885235 no 1590 0.474874225226768 2254 16457353
SGTC_3321 9137793 26.8275 µM 0.0627869235196729 0.479723704626962 no 1591 0.474968089421487 2312 4904192
SGTC_366 0181-0206 4.31 µM 0.0626607748193064 0.479775867447032 no 1592 0.475018316570538 2299 274874
SGTC_2610 ononetin 44.17 µM 0.0625260389193996 0.479831581479241 no 1593 0.475071963222618 2229 259632
SGTC_1741 st038134 10.228 µM 0.0625165703517101 0.479835496798647 no 1594 0.475075733259026 2259 1272587
SGTC_1268 0828-0275 2.46 µM 0.0590055570024137 0.481287456448896 no 1595 0.476473840989045 2264 745337
SGTC_2396 5342950 42.78 µM 0.0586107063302741 0.48145076059076 no 1596 0.476631091463119 2231 1886677
SGTC_1015 4130-4525 82 µM 0.0571114146542432 0.482070872596912 no 1597 0.477228221843334 2226 1363237
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.054510571636505 0.483146691915749 no 1598 0.478264193082896 2295 6710655
SGTC_515 4092-1064 102 µM 0.0542560175931949 0.483251993017117 no 1599 0.47836559539139 2303 717353
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0518671858982688 0.484240234416008 no 1600 0.479317260463365 2307 66535 A nucleotide analog.
SGTC_676 falcarinol 140 µM 0.05154683921232 0.484372766884815 no 1601 0.479444889570583 2317 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2626 ethyl orsellinate 100 µM 0.0511360544600213 0.484542717530243 no 1602 0.479608553129061 2289 75653 A natural product.
SGTC_3141 9094609 49.47 µM 0.0511329252851703 0.484544012149202 no 1603 0.479609799858212 2242 25236309 YDL196W YDL196W
SGTC_1385 3091-4834 14.1 µM 0.0507933524062429 0.484684503022542 no 1604 0.479745094026299 2270 4072814
SGTC_1168 k815-0004 80.5 µM 0.0507149081966407 0.484716957874542 no 1605 0.479776348456797 2298 642433
SGTC_784 4579-0127 173 µM 0.0497095294543472 0.48513292376628 no 1606 0.480176931221592 2317 1948547
SGTC_2846 9008642 19.48 µM 0.0496517050703432 0.485156848551487 no 1607 0.480199971362235 2211 2992898
SGTC_1982 st072467 71.9 µM 0.049097057448491 0.485386336191955 no 1608 0.480420974198622 2195 3163533
SGTC_1866 st057638 64 µM 0.0487668762597544 0.485522952263813 no 1609 0.480552539833828 2272 688802
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0486550327771368 0.485569229111964 no 1610 0.480597106024061 2262 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2009 4012297 12.05 µM 0.0480367164065139 0.485825069885862 no 1611 0.480843490454657 2245 45595307
SGTC_1143 3454-2408 5.08 µM 0.0479111696672348 0.485877018078089 no 1612 0.480893518753907 2319 X1143
SGTC_2508 celastrol 40.54 µM 0.0475232769374138 0.486037520181283 no 1613 0.481048089489282 2319 122724 Celastrol is a natural product and antioxidant.
SGTC_3159 9100096 49.47 µM 0.047390999566808 0.486092254378838 no 1614 0.48110080113363 2326 25236875
SGTC_1327 1436-0082 2.18 µM 0.0468484542451244 0.486316753428082 no 1615 0.481317005249948 2176 15992205
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.046410160903065 0.486498117370474 no 1616 0.481491669005632 2271 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1897 st060201 15 µM 0.0452048019438905 0.486996904128399 no 1617 0.48197203338361 2193 611878
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0450223841710665 0.487072391789621 no 1618 0.482044733527146 2264 2374 Ca(2+)-ATPase inhibitor.
SGTC_3049 9092223 49.47 µM 0.0442387090458049 0.487396695482665 no 1619 0.48235706344303 2268 8623917
SGTC_1938 st074717 56.4 µM 0.0421916649559763 0.488243850538897 no 1620 0.483172953523441 2337 17250979
SGTC_866 0495-0101 262 µM 0.042145629939348 0.488262902436718 no 1621 0.483191302516654 2292 635694
SGTC_2466 5983409 37.09 µM 0.0419822404517039 0.48833052247885 no 1622 0.483256427850326 2211 2879657
SGTC_2703 st077852 53.4 µM 0.0404762686806167 0.488953796447607 no 1623 0.483856713191401 2290 6281836
SGTC_1650 st011916 45.8 µM 0.0403035812455865 0.489025268054609 no 1624 0.483925549339749 2329 242528
SGTC_2910 7948405 25.97 µM 0.0402201562185511 0.489059796001427 no 1625 0.48395880414602 2315 2971328
SGTC_3122 9126309 49.47 µM 0.0392796759394905 0.489449047552257 no 1626 0.484333705180107 2346 17591206
SGTC_1556 plumbagin 1.48 µM 0.0385380873518926 0.489755987736053 no 1627 0.48462933235573 2335 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3330 9141424 71.43 µM 0.0384586219566834 0.489788878469104 no 1628 0.484661010977187 2326 27261020
SGTC_206 4546-0025 72.014 µM 0.0382443003740787 0.489877586533806 no 1629 0.484746450061438 2289 6620745 YIL048W NEO1
SGTC_1697 st025554 27.742 µM 0.0376199378563288 0.490136014071546 no 1630 0.48499535553132 2330 1269519
SGTC_1924 st058459 75.1 µM 0.0372326988546947 0.490296296795429 no 1631 0.485149733382068 2344 688683
SGTC_978 1416-0512 87.4 µM 0.0366838766995814 0.490523463342743 no 1632 0.485368532260042 2300 6814003
SGTC_2778 tioconazole 65.09 nM 0.0353684863212894 0.491067937501355 no 1633 0.485892956627486 2321 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3214 9129694 49.47 µM 0.0352955567272105 0.491098125446219 no 1634 0.485922033171508 2324 17158655
SGTC_416 estradiol valerate 100 µM 0.0350448329819482 0.491201908594646 no 1635 0.486021995630897 2268 13791 A steroid.
SGTC_2374 9071832 200 µM 0.0341905651604241 0.491555523744423 no 1636 0.486362595027565 2349 17381698
SGTC_2303 7774051 200 µM 0.0340757981488655 0.491603030849547 no 1637 0.486408353776914 2331 2953184
SGTC_216 k038-0035 28.382 µM 0.033391114366733 0.491886453980951 no 1638 0.486681347710598 2334 4444231 YPR107C YTH1
SGTC_1953 st076800 12.1 µM 0.03308492635525 0.492013201073072 no 1639 0.486803431597962 2193 297591
SGTC_1966 st070145 16.1 µM 0.0326981051594895 0.492173327571845 no 1640 0.486957667474195 2349 3748532
SGTC_2379 9035213 200 µM 0.0316842097142295 0.492593040398417 no 1641 0.487361943693848 2369 646551
SGTC_1915 st067105 30.6 µM 0.0315594988171657 0.492644666379279 no 1642 0.487411671274925 2352 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1292 0kpi-0043 232 µM 0.0314838992609471 0.492675962030432 no 1643 0.487441816154313 2318 3333905
SGTC_318 1488-0629 67.2 µM 0.031396002392867 0.492712348408108 no 1644 0.487476864604832 2278 3662576
SGTC_2636 apigenin dimethyl ether 100 µM 0.0309317549110152 0.492904532411551 no 1645 0.487661982638278 2325 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2404 5161160 200 µM 0.0291149424173863 0.493656651636847 no 1646 0.488386459262215 2345 2831543
SGTC_182 3448-4371 550.524 µM 0.0284333872539115 0.493938805998877 no 1647 0.488658247890754 2344 3491403
SGTC_2785 7756463 72.73 µM 0.0281156496184497 0.494070346007405 no 1648 0.488784956208578 2343 2201551
SGTC_313 3474-0040 5.03 µM 0.02795716084634 0.494135958918719 no 1649 0.488848159235739 2355 1043375 YIL048W NEO1
SGTC_736 0958-0254 92.6 µM 0.0279492267050627 0.494139243585288 no 1650 0.488851323263756 2320 6812352
SGTC_2506 ethyl hematommate 54.16 µM 0.027927154523228 0.494148381281707 no 1651 0.488860125354437 2223 3940691 An allergen.
SGTC_2940 9060638 45.86 µM 0.0261471507742859 0.494885297453469 no 1652 0.489569984511834 2316 4027022
SGTC_2440 5628896 157.78 µM 0.025996984532784 0.494947466657001 no 1653 0.489629871816863 2341 5522048
SGTC_2926 9010726 65.15 µM 0.0255677177861368 0.495125184846714 no 1654 0.489801067561458 2342 2994293
SGTC_1712 st032288 53.4 µM 0.0254678854076055 0.495166515999909 no 1655 0.489840881953347 2342 2883011
SGTC_1701 st028638 40.4 µM 0.0248760903119448 0.495411523471288 no 1656 0.490076899249353 2363 3490878
SGTC_1113 artemisinin 1.17947 µM 0.02479081877009 0.495446826654293 no 1657 0.490110907184731 2366 2240 An anti-malaria and mitochondrial poison.
SGTC_490 phenamil 164 µM 0.024776352434983 0.4954528158503 no 1658 0.490116676645299 2358 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1146 3579-1023 7 µM 0.0246613707204694 0.495500419375731 no 1659 0.490162533700689 2351 X1146
SGTC_1641 st009299 47.1 µM 0.0245341801332677 0.495553077565398 no 1660 0.490213260055232 2369 4046054
SGTC_511 blebbistatin 171 µM 0.0240501203368213 0.495753483918247 no 1661 0.4904063150023 2362 3476986 A myosin inhibitor.
SGTC_2884 9058502 51.95 µM 0.0240152761871748 0.495767909841051 no 1662 0.49042021179305 2329 6471554
SGTC_1309 pyrazolanthrone 13.4 µM 0.0237094411345118 0.495894529692773 no 1663 0.490542187593714 2369 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2444 5485484 36.41 µM 0.0233929688086028 0.49602555395488 no 1664 0.490668406775397 2337 6790631
SGTC_3288 9119690 36.221 µM 0.0213599245824387 0.496867274195397 no 1665 0.491479270908104 2351 17595618 YKL019W RAM2
SGTC_1322 1348-1070 12 µM 0.0208075487991784 0.497095971185376 no 1666 0.491699587986364 2356 6758089
SGTC_674 0498-0004 451 µM 0.0190288786198051 0.497832389945171 no 1667 0.492409033885252 2356 4231473
SGTC_583 1488-1091 88.9 µM 0.0189692862974351 0.497857062960434 no 1668 0.492432803491843 2381 4303273
SGTC_2223 6903751 107.57 µM 0.018851473438975 0.497905841054177 no 1669 0.492479795619229 2366 5598863
SGTC_3114 9122766 49.47 µM 0.0182330492932617 0.49816188788852 no 1670 0.492726468745583 2289 17176985
SGTC_675 1309-0189 238 µM 0.0171822770750889 0.498596941954284 no 1671 0.4931456004743 2358 4246530
SGTC_2816 7982706 58.44 µM 0.0166958343637336 0.498798345743178 no 1672 0.493339635197596 2357 2981853
SGTC_2946 9065502 71.43 µM 0.0161286352930766 0.499033185788282 no 1673 0.493565884411792 2378 16489101
SGTC_777 1315-0167 517 µM 0.0156998748579743 0.499210707673864 no 1674 0.493736913417133 2302 4221767
SGTC_2683 piperine 63.03 µM 0.0149501000808076 0.49952114113114 no 1675 0.494035995147001 2379 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2283 7944793 200 µM 0.01407762598885 0.49988237682617 no 1676 0.494384025281209 2372 2970533
SGTC_1949 st076024 69.1 µM 0.0137935368401417 0.5 no 1677 0.494497349449316 2381 2921930
SGTC_2122 5258151 111.688 µM 0.0128448344815088 0.499607202997593 no 1678 0.494875793347904 2366 2173356
SGTC_59 0330-0160 1.33 µM 0.0127488741812296 0.49956747198621 no 1679 0.494914072834468 2338 4293482
SGTC_3331 9141060 1.957 µM 0.012118983825548 0.499306674876808 no 1680 0.49516534330093 2376 4906567 YPR165W RHO1
SGTC_2459 5811157 9.22 µM 0.0118891136102282 0.49921150046372 no 1681 0.495257041641649 2383 2870684 YBR192W RIM2
SGTC_2093 5331342 194.4 µM 0.0115886683048622 0.499087105531481 no 1682 0.495376893718271 2388 33839
SGTC_1801 st050089 28.441 µM 0.0110672539982617 0.498871221872237 no 1683 0.495584894582379 2373 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2773 thioridazine 9.09 µM 0.0109350145315571 0.498816470183393 no 1684 0.495637647304453 2393 5452 An antipsychotic.
SGTC_3071 9117417 49.47 µM 0.010327207675315 0.498564817536238 no 1685 0.495880113451781 2386 45595590 YGL055W OLE1
SGTC_2201 6605497 169.863 µM 0.00993776920955804 0.498403577100745 no 1686 0.496035468945233 2380 670741
SGTC_350 k064-0020 19.8 µM 0.0095772086639056 0.498254293313451 no 1687 0.496179304943385 2387 2790705
SGTC_3275 9138069 49.47 µM 0.0091944901759607 0.498095835685627 no 1688 0.496331980803711 2310 17617007
SGTC_744 1594-0068 283 µM 0.00896927022262298 0.498002587599776 no 1689 0.496421826859946 2381 668392
SGTC_2276 7947513 42.08 µM 0.00852009300979369 0.497816614553608 no 1690 0.496601015788659 2369 2105100
SGTC_2873 9040596 71.43 µM 0.00838283844935975 0.497759787078169 no 1691 0.496655770480427 2327 6463863
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.00831545969178736 0.497731890282567 no 1692 0.496682649778747 2325 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1261 0712-0010 12.7 µM 0.00821580572962085 0.497690630619419 no 1693 0.496722404599587 2382 2840123
SGTC_673 1082-0474 110 µM 0.0081739902762267 0.497673317802615 no 1694 0.496739085991778 2375 3098046
SGTC_2959 9079155 11 µM 0.00757907859481599 0.497427007512509 no 1695 0.496976414049092 2383 16189457
SGTC_2937 9044753 11.33 µM 0.00721397637728907 0.497275845330707 no 1696 0.497122064775293 2393 6465530 YGL099W LSG1
SGTC_231 b-estradiol 524 µM 0.0070234547590289 0.497196964387467 no 1697 0.497198069978184 2393 450 A steroid.
SGTC_2239 6685329 187.64 µM 0.00692701483896664 0.497157035774602 no 1698 0.497236543003858 2316 805680
SGTC_1405 3909-7894 12 µM 0.0063508747497207 0.496918499533423 no 1699 0.497466384576457 2393 7104060
SGTC_469 w7 172 µM 0.00586279057580634 0.496716421476849 no 1700 0.497661098357089 2399 45115570 A P450 inhibitor.
SGTC_799 1310-0557 151 µM 0.0056756294993454 0.496638932713802 no 1701 0.497735763581045 2375 5354492
SGTC_979 1426-2828 121 µM 0.00565708224189983 0.496631253752017 no 1702 0.49774316274744 2393 747872
SGTC_2164 5685496 200 µM 0.00564797953251942 0.496627485035849 no 1703 0.497746794145064 2392 759046
SGTC_1564 D-Arginine 115 µM 0.00543099801083647 0.496537650139795 no 1704 0.497833355919835 2390 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2780 5215298 71.43 µM 0.00490159282984753 0.496318466049016 no 1705 0.498044555208991 2397 2834131
SGTC_2256 7954252 200 µM 0.00432329594132247 0.496079041108221 no 1706 0.498275259831141 2368 2972920
SGTC_1018 4259-0013 28.1 µM 0.00413620380320304 0.496001582016658 no 1707 0.498349898127587 2368 6801262
SGTC_714 4296-0578 26.1 µM 0.00408044281292206 0.495978496117569 no 1708 0.498372143356472 2394 1589775
SGTC_3208 9114115 49.47 µM 0.00388298755666402 0.495896746743492 no 1709 0.498450915982118 2387 650895
SGTC_368 fentichlor 4.58 µM 0.00263996698732842 0.49538212208012 no 1710 0.498946806773249 2400 7329 A pesticide.
SGTC_1527 coumarin 137 µM 0.00195466233674253 0.495098401386434 no 1711 0.499220203046528 2397 323 A hepatotoxic, DNA x-linker.
SGTC_3322 9139058 2.11 µM 0.00164775545432313 0.494971340686472 no 1712 0.499342640978974 2395 4908926 YPR165W RHO1
SGTC_3345 9148410 3.559 µM 0.000355524917407668 0.494436357725718 no 1713 0.499858166081698 2405 4903596
SGTC_390 dec-rvkr-cmk 16.7 µM 0 0.494289172256792 no 1714 0.5 2405 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2108 5365811 200 µM 0 0.494289172256792 no 1715 0.5 2405 780283
SGTC_3013 9080133 71.4286 µM 0 0.494289172256792 no 1716 0.5 2405 17050193
SGTC_1444 4112-3581 28 µM -4.72961160568203e-05 0.494269591968593 no 1717 0.499981131579613 2406 2877249
SGTC_2540 epiandrosterone 100 µM -0.00118331021144203 0.493799293688292 no 1718 0.499527927635993 2406 441302 A steroid.
SGTC_785 1270-0111 65.3 µM -0.00186664231166459 0.493516405258888 no 1719 0.499255317891947 2412 6741994
SGTC_1098 clofazimine 15.1 µM -0.00216495052168689 0.493392911502238 no 1720 0.499136310376609 2413 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_911 3456-4043 236 µM -0.00311705813065531 0.492998761892586 no 1721 0.498756475734904 2413 914281
SGTC_2555 cholic acid 100 µM -0.00356920671061972 0.492811585644925 no 1722 0.498576095558884 2431 6708657 Influences liver metabolism.
SGTC_1334 1486-0610 236 µM -0.0044245763980223 0.492457492050636 no 1723 0.498234855161302 2433 3742339
SGTC_1206 3978-0017 132 µM -0.00698384485276112 0.491398079643464 no 1724 0.497213871656967 2430 3873677
SGTC_233 rapamycin 362 pM -0.0071423819073802 0.491332454948503 no 1725 0.497150626100538 2421 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3093 9117344 49.47 µM -0.00719769777776762 0.491309557598789 no 1726 0.497128558828307 2458 24824913
SGTC_2956 9076196 2.52 µM -0.00871227261465142 0.490682628658928 no 1727 0.496524350064799 2418 16423868
SGTC_1008 4106-0037 6 µM -0.00875821775820645 0.490663610907887 no 1728 0.496506021303754 2416 2905394
SGTC_1678 st019265 80.2 µM -0.00931882034659479 0.4904315663326 no 1729 0.496282382366931 2426 5367020
SGTC_1621 st003705 32.4 µM -0.0103320207284943 0.490012190786466 no 1730 0.495878193423807 2416 24207032
SGTC_3179 9107801 49.47 µM -0.0103719876416518 0.489995648234703 no 1731 0.495862249786647 2423 4818259
SGTC_2861 9024595 19.48 µM -0.0120612477148007 0.489296469168595 no 1732 0.495188374993266 2423 16482810
SGTC_533 1222-0222 6.71 µM -0.0121329565428487 0.489266789838272 no 1733 0.495159769403032 2493 3982874
SGTC_225 nsc-122657 1.016 µM -0.0127039482988649 0.489030466078042 no 1734 0.49493199421708 2446 275685
SGTC_1032 k061-1018 98.7 µM -0.0130499424617227 0.488887266857051 no 1735 0.494793973960871 2434 4005393
SGTC_3035 9091303 49.47 µM -0.0144714636806568 0.488298946352796 no 1736 0.494226922781972 2434 25237002
SGTC_2277 7947813 106.88 µM -0.0148950003193629 0.488123663444799 no 1737 0.494057974324153 2486 1246798
SGTC_1804 st050076 49.1 µM -0.0154088325788651 0.487911014293126 no 1738 0.493853008442501 2439 3895976
SGTC_3164 9100705 49.47 µM -0.0159917380586028 0.487669783397623 no 1739 0.49362049146381 2465 17174235
SGTC_666 0272-0154 136 µM -0.0163183637594681 0.487534613860185 no 1740 0.493490203665181 2444 6870312
SGTC_470 aa-861 153 µM -0.0166355797150517 0.487403339786438 no 1741 0.493363669986529 2443 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_35 0133-0054 64.071 µM -0.01976578086666 0.486108038208586 no 1742 0.492115107730109 2465 99677
SGTC_1657 st012939 43.4 µM -0.0210619261894532 0.485571725319625 no 1743 0.491598128325934 2459 24207257
SGTC_1181 1222-0449 220 µM -0.0212164417446522 0.485507792325072 no 1744 0.491536499309514 2450 658318
SGTC_1347 1493-0251 600 nM -0.0212960428678037 0.485474856380739 no 1745 0.491504750229299 2445 3986378
SGTC_1112 tnp00069 1.16933 µM -0.0215024503460312 0.485389453208572 no 1746 0.491422424411186 2523 145826
SGTC_3294 9122953 26.2835 µM -0.0222117702861252 0.485095970075021 no 1747 0.491139514288541 2447 16459826
SGTC_3252 9135871 49.47 µM -0.0230684867093256 0.48474151200775 no 1748 0.490797821478349 2482 17682838
SGTC_2936 9038235 15.59 µM -0.0248731043246933 0.483994908848375 no 1749 0.490078090117437 2441 4749415
SGTC_1673 st016611 27.3 µM -0.0275292533865591 0.482896114449525 no 1750 0.489018803928229 2499 5226799
SGTC_740 k014-0057 261 µM -0.0277338510754977 0.482811481862899 no 1751 0.488937212413397 2495 4012779
SGTC_291 SEC14.278 35.5 µM -0.0280626539410985 0.482675472972182 no 1752 0.488806090085985 2453 1068044
SGTC_3087 9117406 49.47 µM -0.028695758520498 0.482413595753393 no 1753 0.488553619593295 2540 42546093
SGTC_382 3229-0966 23.2 µM -0.0303440733830882 0.48173182308485 no 1754 0.487896323632182 2471 5722370
SGTC_342 k048-0088 23.3 µM -0.0313360529669113 0.481321548112737 no 1755 0.487500769203632 2453 6820570
SGTC_713 1488-1073 324 µM -0.0316854066118074 0.481177062874501 no 1756 0.487361466440423 2453 3312542
SGTC_1501 4491-0275 38.4 µM -0.0333769588054257 0.480477508173025 no 1757 0.486686991816469 2459 5104718
SGTC_2172 5754775 163.918 µM -0.0337204604724312 0.480335457633464 no 1758 0.486550031575942 2478 2263357
SGTC_923 1900-2434 73.3 µM -0.0348962506949764 0.47984924425939 no 1759 0.486081235153003 2464 5910570
SGTC_2361 9034121 116 µM -0.0354320454510439 0.47962769203805 no 1760 0.485867616086416 2489 6496917
SGTC_460 trequinsin 123 µM -0.0358574874532184 0.479451775384445 no 1761 0.485697997074068 2463 5537 A vasodilator.
SGTC_2717 st081029 62.2815 µM -0.0361928533990843 0.479313107234238 no 1762 0.485564292209587 2465 5292846
SGTC_3063 1327-0034 4 µM -0.0362687647785604 0.479281719508806 no 1763 0.485534027820878 2456 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_6 0844-0013 19.835 µM -0.0371678943149835 0.478909958578321 no 1764 0.485175568770423 2481 1584900
SGTC_1663 st014140 55.4 µM -0.0382451063731435 0.478464590481288 no 1765 0.484746128749403 2471 4207120
SGTC_151 3013-0144 2.285 µM -0.0387858443621856 0.478241035086532 no 1766 0.484530565452697 2567 906558 YHR107C CDC12
SGTC_553 k007-0256 45.7 µM -0.0409447365688391 0.477348560842125 no 1767 0.483669976353303 2502 6287000
SGTC_1374 2889-5571 141 µM -0.0414701503209506 0.477131374683401 no 1768 0.483460544484042 2531 2853281
SGTC_441 propafenone 146 µM -0.0427533160907272 0.476600991201094 no 1769 0.482949089148846 2467 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2375 9072683 200 µM -0.0450888855519231 0.475635714428946 no 1770 0.482018230229262 2478 16798029
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.0468898007075314 0.474891504387897 no 1771 0.48130052850525 2473 5355888
SGTC_1562 morin hydrate 59.1 µM -0.0471122977190144 0.474799565767084 no 1772 0.481211863029786 2569 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1217 1183-1422 255 µM -0.048148157059145 0.474371553138089 no 1773 0.480799083450387 2536 2849664
SGTC_1916 st067606 49.2 µM -0.049404872861445 0.473852323325791 no 1774 0.48029832246212 2557 19590279
SGTC_1344 1488-0097 29.1 µM -0.0494308011867656 0.473841611138067 no 1775 0.480287991179724 2549 747966
SGTC_1445 4239-0156 97.7 µM -0.0498242297099092 0.473679069984725 no 1776 0.480131229071383 2585 4008346
SGTC_656 4090-1979 187 µM -0.0500601298960113 0.473581612225544 no 1777 0.480037235806537 2490 22330961
SGTC_1394 3474-0001 65.7 µM -0.0502065894239657 0.473521106000222 no 1778 0.479978880288648 2549 5017666 YIL048W NEO1
SGTC_584 0986-0246 15.4 µM -0.0516430702056015 0.472927691169151 no 1779 0.479406550023361 2491 53315 YDR232W HEM1
SGTC_1036 k216-0215 33.5 µM -0.0518114069270946 0.472858154635467 no 1780 0.479339483173566 2499 622330
SGTC_2104 5389443 200 µM -0.0540763447177364 0.471922635409733 no 1781 0.478437169422687 2577 2244536
SGTC_2390 9097792 176.6 µM -0.0545101913091559 0.471743455145434 no 1782 0.478264344586302 2523 4497149
SGTC_954 1189-0853 2.85 µM -0.0547751374593844 0.47163403420522 no 1783 0.478158804045496 2473 2828194
SGTC_2667 digitoxin 100 µM -0.0552137949933408 0.47145287636765 no 1784 0.477984069442777 2506 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2531 methyl deoxycholate 70.07 µM -0.0555779710490219 0.471302482554798 no 1785 0.477839006965191 2517 16667744 Haematoxylin.
SGTC_3180 9109287 49.47 µM -0.0559950942367071 0.471130228190246 no 1786 0.477672857631711 2570 18891271
SGTC_1963 st076565 50.3 µM -0.0567435794367407 0.47082114878824 no 1787 0.477374729274313 2514 4914280
SGTC_1835 st008666 49.2 µM -0.0569321852810674 0.470743268675262 no 1788 0.477299607868381 2516 690455
SGTC_2877 9040724 71.43 µM -0.0579130647243985 0.470338256907511 no 1789 0.476908938222149 2514 6463895
SGTC_2429 5902844 64.44 µM -0.0610580689479764 0.46903987232467 no 1790 0.47565648147158 2586 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2248 tofa 1.1 µM -0.0611299747072682 0.469010190523965 no 1791 0.475627848709492 2509 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_491 tetrandrine 80.3 µM -0.0637246567781308 0.467939254650367 no 1792 0.474594735687503 2572 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_121 0557-0495 61.343 µM -0.0639907973323779 0.467829420088361 no 1793 0.474488777227785 2533 3104427
SGTC_540 1187-0821 17.3 µM -0.0640676179861519 0.467797717134403 no 1794 0.47445819297902 2525 847520
SGTC_2755 lomerizine 42.69 µM -0.0648904080850477 0.467458174469345 no 1795 0.474130628869092 2540 3949 A calcium channel blocker.
SGTC_1968 st069590 43.6 µM -0.0654405131478474 0.467231174550802 no 1796 0.473911634182175 2562 6384066
SGTC_2517 totarol 10 µM -0.0661414659022792 0.466941943039559 no 1797 0.47363259904694 2577 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2474 5321570 43.32 µM -0.0678374967549937 0.466242188686388 no 1798 0.472957497202718 2659 2841384
SGTC_1214 0358-0031 63.7 µM -0.0679848844292028 0.466181383860008 no 1799 0.472898833460541 2719 4301366
SGTC_13 0199-0087 65 µM -0.0706832384664768 0.465068318103318 no 1800 0.471824930616584 2531 4589825
SGTC_2584 androsterone 48.74 µM -0.0710901619672471 0.464900486454067 no 1801 0.471662998986962 2538 2754130 A steroid.
SGTC_2192 5915882 198.485 µM -0.0733978457076603 0.463948823672976 no 1802 0.470744765924841 2529 2876149
SGTC_215 1287-0124 461.5 µM -0.0740105934165164 0.463696167845887 no 1803 0.470500978026411 2617 5560863
SGTC_1391 3442-0225 151 µM -0.0767226611722465 0.462578071224073 no 1804 0.469422088332363 2559 5227075
SGTC_2005 4024620 188 µM -0.0771726197681409 0.462392596400459 no 1805 0.469243111466208 2548 236743
SGTC_607 4491-0986 66.8 µM -0.0772002667043978 0.462381200483413 no 1806 0.469232114741104 2581 698981 YDR232W HEM1
SGTC_947 3447-0010 211 µM -0.0781821533865761 0.46197649221516 no 1807 0.468841579046877 2526 748350
SGTC_3 0833-0587 95.581 µM -0.0784084020369403 0.461883243944507 no 1808 0.468751595125164 2502 5382644
SGTC_295 k015-0027 31 µM -0.0792390817416702 0.461540897716976 no 1809 0.4684212297848 2608 3887424
SGTC_2839 9003951 25.97 µM -0.0797812162824479 0.461317484334348 no 1810 0.468205631965681 2524 2990634
SGTC_3200 9114385 49.47 µM -0.0811785826178227 0.460741686794503 no 1811 0.467649965943754 2608 17018030 YLR208W SEC13
SGTC_2886 9058944 51.95 µM -0.0829546286626186 0.460009969760664 no 1812 0.466943808146266 2536 4949929
SGTC_642 0335-0876 158 µM -0.0831657664654717 0.459922991600408 no 1813 0.46685986640674 2561 6812350
SGTC_106 0092-0003 11.579 µM -0.0832406537587772 0.45989214226091 no 1814 0.466830093931804 2671 1072148
SGTC_443 clozapine 122 µM -0.0832986402391029 0.459868255268625 no 1815 0.466807040735338 2537 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_825 1988-2224 89.6 µM -0.0833455785998722 0.459848919552712 no 1816 0.466788379928232 2551 1180859
SGTC_2740 felodipine 17.08 µM -0.0836229187097835 0.459734674435397 no 1817 0.466678122130412 2599 3333 L-type calcium channel blocker
SGTC_2279 7948423 32.93 µM -0.0843600691032247 0.45943103518179 no 1818 0.4663850771565 2539 1247112
SGTC_1997 st073024 93.8 µM -0.0853198964943802 0.459035708646765 no 1819 0.466003537045756 2542 686268
SGTC_1848 st056003 16.4 µM -0.086362516338178 0.458606328084762 no 1820 0.465589121596771 2536 146492
SGTC_891 0929-0073 133 µM -0.0876198129309324 0.458088601796628 no 1821 0.465089427150736 2718 5603632
SGTC_1228 0124-0032 52.5 µM -0.088900902223096 0.457561151348143 no 1822 0.464580333261329 2603 X1228
SGTC_1625 st003711 30.1 µM -0.0890738126296533 0.457489966330322 no 1823 0.464511624572248 2647 24207034 YER133W GLC7
SGTC_3068 9116768 49.47 µM -0.0914381186646861 0.456516749344127 no 1824 0.463572237142173 2638 41904888
SGTC_1118 chelidonine 707.474 nM -0.0915579041921309 0.456467449036115 no 1825 0.463524649248439 2569 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_590 k048-0076 22.4 µM -0.0925266434758666 0.456068768254793 no 1826 0.46313981179103 2632 6832814
SGTC_582 0987-0078 156 µM -0.0927681393471241 0.455969388465212 no 1827 0.463043881473243 2574 1625765
SGTC_2533 agelasine 13.65 µM -0.0930309182262465 0.455861253474002 no 1828 0.46293949926754 2626 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2070 5230947 200 µM -0.0933020644921191 0.455749678683315 no 1829 0.462831796005927 2567 2835538
SGTC_769 0302-0231 76 µM -0.0935577277670505 0.455644478231391 no 1830 0.462730245310338 2619 571869 YER009W NTF2
SGTC_2054 5233173 129 µM -0.0940542096801018 0.455440194496112 no 1831 0.462533047225439 2657 6889
SGTC_3271 9137798 49.47 µM -0.0966874815258502 0.454356899871099 no 1832 0.461487290772219 2578 6498326
SGTC_1648 st011736 69.8 µM -0.0981017980325289 0.453775207597891 no 1833 0.460925729895939 2684 2855514
SGTC_1254 0550-0035 264 µM -0.0986449640319906 0.453551835890202 no 1834 0.460710083982096 2670 15121435
SGTC_2964 9083345 53.42 µM -0.0992742522288254 0.453293065647835 no 1835 0.460460260578467 2624 17741579
SGTC_2855 9016525 58.44 µM -0.100779204456263 0.452674293332344 no 1836 0.459862867610714 2585 43811474
SGTC_689 0833-0039 98 µM -0.10119145489704 0.452504813480357 no 1837 0.459699239952148 2649 5374726
SGTC_797 k781-0471 270 µM -0.102285917518931 0.45205491214682 no 1838 0.459264866434896 2638 23738129
SGTC_510 ag-490 170 µM -0.102290553035731 0.452053006752972 no 1839 0.459263026780515 2586 5328779
SGTC_3263 9137018 49.47 µM -0.102611420289427 0.451921119400389 no 1840 0.459135689303944 2588 43844957
SGTC_1969 st069479 40.1 µM -0.103223581859137 0.45166951490765 no 1841 0.458892762131682 2676 3895485
SGTC_2323 6148992 148.28 µM -0.103383969828537 0.451603597062486 no 1842 0.458829117096534 2652 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2904 7225135 42.03 µM -0.103681404314725 0.451481358007914 no 1843 0.458711092158579 2668 4446116
SGTC_3213 9129884 49.47 µM -0.104135934010532 0.451294565156066 no 1844 0.458530737326224 2667 17190742
SGTC_3221 9128209 49.47 µM -0.104228542722424 0.451256508137861 no 1845 0.458493991754717 2632 16460723
SGTC_40 0327-0103 19.753 µM -0.106816012575486 0.450193384652126 no 1846 0.457467471978532 2638 409036
SGTC_406 estrone 100 µM -0.10695255217784 0.450137293969721 no 1847 0.457413310818835 2632 5870 A steroid.
SGTC_2242 6630449 61.2675 µM -0.107321058390064 0.449985916015645 no 1848 0.457267139422115 2775 691249 YDR170C SEC7
SGTC_3024 9090631 49.47 µM -0.108297377681904 0.449584890939637 no 1849 0.456879901345092 2591 25236383
SGTC_3279 9140807 49.47 µM -0.110161591404199 0.448819304821898 no 1850 0.456140611223874 2602 45595718
SGTC_695 3505-6186 243 µM -0.110560035966977 0.448655698186593 no 1851 0.455982619906296 2702 1819379
SGTC_2539 epi(13)torulosol 80 µM -0.111052715698364 0.448453409413908 no 1852 0.455787272066912 2678 6708597
SGTC_79 0052-0007 94.094 µM -0.111111076545078 0.448429447991476 no 1853 0.45576413265968 2655 2801472
SGTC_858 0438-0351 2.77 µM -0.111208298339834 0.448389531707835 no 1854 0.4557255856649 2615 2799119
SGTC_3086 9117350 49.47 µM -0.111970482886746 0.448076620272464 no 1855 0.455423405303963 2603 2679265
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.112509804922252 0.447855223543922 no 1856 0.455209597950772 2603 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_522 1273-0010 11.6 µM -0.113148695355745 0.447592974082594 no 1857 0.454956334765949 2843 5705015
SGTC_2960 9079389 5.97 µM -0.114878003510237 0.446883249095406 no 1858 0.454270910153305 2662 16457355
SGTC_1914 st062367 72.6 µM -0.116123441237109 0.446372214489359 no 1859 0.453777355534304 2646 978205
SGTC_2261 9010538 184.68 µM -0.117265281016564 0.445903766972664 no 1860 0.453324918452189 2731 6457250
SGTC_1371 2421-0008 32.7 µM -0.117881538928122 0.445650974312407 no 1861 0.45308076052431 2674 2827552
SGTC_2961 9083290 32.55 µM -0.117964004502725 0.445617148117119 no 1862 0.453048089469719 2600 17741490
SGTC_3136 9095672 49.47 µM -0.118987164572893 0.445197495541401 no 1863 0.452642762361081 2567 17217380
SGTC_1797 st048695 56.8 µM -0.119002630215952 0.445191152725325 no 1864 0.452636635990126 2666 592262 YIL048W NEO1
SGTC_2648 atorvastatin 78.68 µM -0.119225489051983 0.445099754747423 no 1865 0.452548356665244 2644 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3057 9095946 49.47 µM -0.119551612508466 0.444966011556086 no 1866 0.45241917616411 2596 24540043
SGTC_2774 tamoxifen 10.92 µM -0.119743318241851 0.444887395979807 no 1867 0.452343242109204 2603 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1424 4048-1941 275 µM -0.119951003393351 0.444802229935969 no 1868 0.452260980622799 2719 X1424
SGTC_2232 chlorophetanol 41.5365 µM -0.119984749586841 0.444788391778467 no 1869 0.452247614371817 2635 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_261 5-fluorouridine 15.376 µM -0.120637299048153 0.444520816857508 no 1870 0.451989162106368 2683 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_813 k007-0158 173 µM -0.121233830870299 0.444276233828948 no 1871 0.451752914287277 2691 6523916
SGTC_2393 9031399 185.94 µM -0.122026785176064 0.443951148806618 no 1872 0.451438902641696 2720 1526623 YDL150W RPC53
SGTC_2016 5121758 140 µM -0.12216455868781 0.443894670065453 no 1873 0.451384347121239 2605 2795203
SGTC_2921 7974240 10.71 µM -0.122197839778359 0.44388102701797 no 1874 0.451371168621047 2734 2979074 YDR527W RBA50
SGTC_477 mead ethanolamide 10 µM -0.122659553776659 0.443691761663308 no 1875 0.451188346673818 2603 16061185
SGTC_2144 5628481 200 µM -0.122678095321091 0.443684161399334 no 1876 0.451181005112704 2630 2818399
SGTC_67 0335-0847 266 µM -0.124070373703021 0.443113519485569 no 1877 0.450629777621136 3012 4552207 YOR254C SEC63
SGTC_1280 0880-0253 10.1 µM -0.124431609410949 0.442965481945619 no 1878 0.450486773566665 2651 6836607
SGTC_2967 9089538 49.85 µM -0.124608131244995 0.442893144654821 no 1879 0.450416895386626 2766 728216
SGTC_2352 9027995 87.8 µM -0.12532137061996 0.44260088404925 no 1880 0.450134567124295 2687 2997347
SGTC_600 1495-0418 41.6 µM -0.127380685611004 0.441757224457166 no 1881 0.449319551177533 2638 5377768
SGTC_2710 st078562 53.7235 µM -0.127499648946721 0.441708495624943 no 1882 0.44927247550737 2609 17250908
SGTC_1943 st076331 65.2 µM -0.127725987581325 0.441615786998204 no 1883 0.449182911708307 2625 24208415
SGTC_169 k015-0017 16.025 µM -0.128330806731445 0.441368067920533 no 1884 0.448943593207411 2701 1840002
SGTC_2919 7978188 46.38 µM -0.12906421416777 0.441067713013198 no 1885 0.44865341904137 2689 2980291
SGTC_604 1000-0114 314 µM -0.129261788464008 0.440986805510123 no 1886 0.448575253052983 2707 1572745
SGTC_854 0422-0053 192 µM -0.129793624850155 0.440769028527038 no 1887 0.448364853440508 2644 3596728
SGTC_1359 1582-0056 520 nM -0.130341264129053 0.440544799275949 no 1888 0.44814821722848 2738 3661189
SGTC_3171 9103192 49.47 µM -0.131117810334147 0.440226877471854 no 1889 0.447841056092966 2646 13018434
SGTC_1793 st048256 72.231 µM -0.132547113410818 0.43964181469766 no 1890 0.447275780306533 2628 672022
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.132874995718202 0.439507619762101 no 1891 0.447146121027999 2667 115019
SGTC_1560 lithocholic acid 53.1 µM -0.13300462490568 0.439454567335305 no 1892 0.447094861426843 2642 9903 A bile acid which acts as a detergent.
SGTC_176 1486-1328 72.834 µM -0.134026205689553 0.439036510272242 no 1893 0.446690926119124 2710 22310231
SGTC_1851 st056236 18.9 µM -0.134746059279388 0.438741968525442 no 1894 0.446406327602592 2644 5393171
SGTC_2117 5521686 200 µM -0.135577887993518 0.43840165228927 no 1895 0.446077493424378 2652 803312
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.136232167756651 0.438134006539904 no 1896 0.445818873013047 2708 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3195 9113082 49.47 µM -0.136799736331146 0.437901854588746 no 1897 0.445594546030897 2629 17018038
SGTC_2975 9084847 53.72 µM -0.13746792231143 0.437628574606691 no 1898 0.445330473143582 2755 27211724
SGTC_1364 1653-0028 37.6 µM -0.137647233873392 0.437555243404655 no 1899 0.445259611784132 2722 5718652
SGTC_1328 1441-0025 69.2 µM -0.13889730586422 0.437044074076494 no 1900 0.44476564997047 2638 4562601
SGTC_1376 2910-0861 41.3 µM -0.139145321238857 0.436942670100991 no 1901 0.444667657686534 2660 1112859
SGTC_2663 amphotericin b 100 µM -0.140508510346124 0.436385388491103 no 1902 0.444129114455862 2660 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2856 9022925 19.48 µM -0.140620352904082 0.436339672029887 no 1903 0.444084934356971 2797 4944862
SGTC_1746 st038117 42 µM -0.140990073070666 0.436188552270782 no 1904 0.443938892273931 2761 2898218
SGTC_1089 terbinafine 2.25 µM -0.141241910718479 0.436085621252123 no 1905 0.443839418977775 2772 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_932 2857-0803 154 µM -0.141299830482774 0.436061948912946 no 1906 0.443816541763262 2890 674898
SGTC_2953 9074162 66.49 µM -0.141607715604305 0.435936117285198 no 1907 0.44369493609173 2725 16451992
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.142900764078339 0.435407723613496 no 1908 0.443184277559825 2773 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1944 st076371 56.9 µM -0.143157541084662 0.435302807484738 no 1909 0.443082880831719 2664 24208455
SGTC_1451 4152-0210 104 µM -0.143778289564946 0.435049195628266 no 1910 0.442837773572886 2686 659563
SGTC_3311 9131146 2.8755 µM -0.144128646497778 0.434906066233545 no 1911 0.442699442124654 2729 4900406 YPR165W RHO1
SGTC_1330 1469-0054 61.8 µM -0.144318172056106 0.434828643951318 no 1912 0.442624614647639 2812 7102664
SGTC_2894 9048625 32.47 µM -0.144588647590963 0.434718157465945 no 1913 0.442517830474917 2765 4092861
SGTC_1213 1315-0166 115 µM -0.144854795438219 0.434609443772766 no 1914 0.442412758956436 2802 768401
SGTC_2558 carylophyllene oxide 100 µM -0.146162019134141 0.434075552655805 no 1915 0.441896743922814 2649 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1267 0828-0272 9.49 µM -0.146255083120055 0.434037548404882 no 1916 0.441860011483363 2765 745334
SGTC_2309 7664088 163.95 µM -0.146515563021534 0.433931180278994 no 1917 0.441757202489595 2713 704922
SGTC_101 0490-5701 117.494 µM -0.147150038627455 0.433672109377869 no 1918 0.441506797302323 2646 4661669
SGTC_2216 7189485 200 µM -0.147226010745708 0.433641090132408 no 1919 0.44147681534683 2750 731273
SGTC_1210 3013-0140 750 nM -0.147975577559158 0.433335065622838 no 1920 0.441181021158059 2828 905973
SGTC_409 arachidonic acid 100 µM -0.148432296167874 0.433148621390217 no 1921 0.441000806854104 2666 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1988 st071872 53.4 µM -0.14935764993409 0.432770913938069 no 1922 0.440635713644497 2660 16414116
SGTC_668 1682-0499 62.6 µM -0.149842729011344 0.432572940681878 no 1923 0.440444348515668 2703 682214
SGTC_2790 5423970 71.43 µM -0.151149465585634 0.432039712200341 no 1924 0.43992890640329 2806 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2096 5468907 200 µM -0.15129050125329 0.431982168401595 no 1925 0.439873280969174 2815 759785
SGTC_2240 6690706 185.951 µM -0.151324906875644 0.43196813082254 no 1926 0.439859711335915 2647 805876
SGTC_2669 eugenol 100 µM -0.151755261874264 0.431792552180553 no 1927 0.43968998460017 2668 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1881 5652484 16 µM -0.152940645907223 0.431309002332726 no 1928 0.43922254107503 2752 2255129
SGTC_3185 9108267 49.47 µM -0.153202269039142 0.43120229310122 no 1929 0.439119384181348 2744 4910486
SGTC_863 0466-0191 129 µM -0.154365136315265 0.430728050828378 no 1930 0.438660920662514 2692 765160 YPR165W RHO1
SGTC_1469 k284-2957 126 µM -0.154857149813473 0.430527427177084 no 1931 0.438466967770352 2707 23884841
SGTC_1317 1273-0028 910 nM -0.156310907234966 0.429934747329574 no 1932 0.437893979643892 2714 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1723 st034307 2.5525 µM -0.156969732914345 0.429666203725241 no 1933 0.437634350996503 2759 867466
SGTC_221 trifluoperazine 10.304 µM -0.156975096008319 0.429664017810554 no 1934 0.437632237629651 2698 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_3038 9091290 49.47 µM -0.157344228418129 0.429513570298305 no 1935 0.437486782551837 2785 25236843
SGTC_933 2914-0560 114 µM -0.157814423483203 0.429321947447492 no 1936 0.437301516395049 2874 463887
SGTC_1462 k081-0014 26.5 µM -0.158323738694431 0.429114400400072 no 1937 0.43710085163816 2710 3270634
SGTC_542 3381-0244 89.3 µM -0.158576404610551 0.429011445762582 no 1938 0.437001309965412 2854 1112843
SGTC_3150 9097574 49.47 µM -0.160292193786406 0.428312435431251 no 1939 0.436325453912441 2776 17217476
SGTC_3172 9105863 49.47 µM -0.161488686620273 0.427825118713012 no 1940 0.435854260590447 2730 2348785
SGTC_1301 naphtanilide LB 4.81 µM -0.162192182183119 0.427538645017297 no 1941 0.435577258001398 2792 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_873 0591-4978 488 µM -0.162696898726291 0.427333140574531 no 1942 0.435378544456833 2898 3305145
SGTC_1283 0922-0125 16.4 µM -0.162893780417316 0.427252981985975 no 1943 0.435301033965511 2809 3360884
SGTC_2055 5235184 200 µM -0.163064237742503 0.427183584263125 no 1944 0.435233928508974 2834 2836034
SGTC_1177 0983-0204 23.6 µM -0.163965062117368 0.426816872107778 no 1945 0.43487932395729 2807 766818
SGTC_2685 mycophenolic acid 18.85 µM -0.165671897705158 0.42612221851231 no 1946 0.434207581388659 2757 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1252 0493-0875 34.8 µM -0.166370591569169 0.425837927753323 no 1947 0.433932657963838 2686 3960963
SGTC_442 cape 100 µM -0.167213697044122 0.425494928845691 no 1948 0.433600953734274 2791 5281787
SGTC_1603 st002045 67.8 µM -0.167578837985815 0.425346396769619 no 1949 0.433457310292975 2736 5887985
SGTC_307 1501-1223 22.3 µM -0.167618448185673 0.425330284764396 no 1950 0.433441728494456 2771 2830329
SGTC_1211 1056-0033 32.3 µM -0.170168041828581 0.424293465244527 no 1951 0.43243899202683 2711 6741922
SGTC_2798 7813637 45.45 µM -0.170261654374433 0.424255406625401 no 1952 0.432402183139095 2840 956368
SGTC_2324 6149169 200 µM -0.170372173942151 0.424210475286505 no 1953 0.432358727087059 2787 2888231
SGTC_2983 9022671 12.99 µM -0.171038285701511 0.423939690789145 no 1954 0.432096830747636 2918 6405161
SGTC_1561 5-methoxyflavone 52.9 µM -0.171421472232529 0.423783935934035 no 1955 0.431946186132323 2699 94525
SGTC_423 5-fluorouracil 457 µM -0.173946356681509 0.422757938186874 no 1956 0.430953810279108 2681 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_998 3996-0085 177 µM -0.173987938412197 0.422741045635099 no 1957 0.43093747070398 2783 715391
SGTC_1681 tripelennamine 100 µM -0.174015282235805 0.422729937301492 no 1958 0.430926725990524 2695 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_3147 9097027 49.47 µM -0.174078924575258 0.422704083059527 no 1959 0.430901718029052 2747 25236841
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.174420315124759 0.42256540129412 no 1960 0.430767574931082 2825 688662
SGTC_2163 5671233 125 µM -0.178331290671887 0.420977349725284 no 1961 0.429231403125909 2837 701023
SGTC_3005 9076496 71.4286 µM -0.179538969586463 0.420487230158478 no 1962 0.428757260553782 2799 21368410
SGTC_1921 5740136 50 µM -0.180195958528655 0.420220652113237 no 1963 0.428499365564272 2825 1774243
SGTC_1043 0916-0009 19.3 µM -0.180341971697251 0.420161411173049 no 1964 0.428442053575525 2781 3101130
SGTC_1696 st025591 34.7925 µM -0.180840963849767 0.419958972105775 no 1965 0.428246204334101 2743 2787147
SGTC_2867 9039098 71.43 µM -0.181353463444857 0.419751075168474 no 1966 0.428045071958422 2703 6463460
SGTC_2308 7584454 197.62 µM -0.181928031040624 0.419518026797257 no 1967 0.427819602993078 2854 893577
SGTC_2176 5809774 33.9695 µM -0.182053293770181 0.419467223160544 no 1968 0.427770451140729 2855 2870539
SGTC_1830 st055982 50.3 µM -0.183623099153743 0.418830660865508 no 1969 0.427154570367005 2711 455313 An antimicrobial agent.
SGTC_68 0986-0284 82.829 µM -0.184035041085562 0.418663651905934 no 1970 0.426992982785877 2942 423278 YIL048W NEO1
SGTC_2656 pseudo-anisatin 100 µM -0.184645237784805 0.41841629370519 no 1971 0.426753650675321 2742 6708809 A neurotoxin.
SGTC_2716 st080858 38.6235 µM -0.186219293616261 0.417778360729162 no 1972 0.426136397233701 2868 5296050
SGTC_109 0132-0036 33.701 µM -0.186604941190837 0.417622098495874 no 1973 0.425985196146344 2703 67274 A color developer.
SGTC_2448 5185112 27.17 µM -0.188013755890268 0.417051365413592 no 1974 0.425432933919499 2876 5718189
SGTC_1300 1094-0077 113 µM -0.190462157084545 0.416059895857843 no 1975 0.424473497316192 2750 5532636
SGTC_428 3448-4153 16.5 µM -0.190470934913378 0.416056342270592 no 1976 0.424470058415666 2692 3834874
SGTC_3249 9135183 49.47 µM -0.191142293298564 0.415784572114141 no 1977 0.424207056591754 2917 4902779
SGTC_229 benomyl 22.8748 µM -0.191403974021481 0.415678652989132 no 1978 0.424104553403394 2815 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3053 9095903 49.47 µM -0.192135869749881 0.415382439968592 no 1979 0.423817889159188 2758 17174018
SGTC_2526 patulin 37.61 µM -0.19290360065023 0.415071775403396 no 1980 0.423517232543908 2895 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1732 st034308 51.822 µM -0.194418628568829 0.414458870853658 no 1981 0.422924052358405 2689 830119
SGTC_2777 climbazole 1.536 µM -0.195347279023842 0.414083288143244 no 1982 0.422560543321312 2792 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2233 sulbentine 40.3845 µM -0.197451778620131 0.413232437133035 no 1983 0.421737006799369 2764 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1312 1218-2183 165 µM -0.203555130374957 0.41076716417801 no 1984 0.4193505798484 2751 6744073
SGTC_320 4092-0846 5.34 µM -0.203559352384892 0.410765460026325 no 1985 0.419348930046873 2859 1359356
SGTC_2696 st077691 74.316 µM -0.203909709794354 0.410624049327414 no 1986 0.419212028588421 2907 757133
SGTC_1418 3966-3099 2.4 µM -0.204068704543497 0.410559879951415 no 1987 0.419149904932762 2843 740335
SGTC_1651 st011928 86.1 µM -0.204528963287112 0.410374135643816 no 1988 0.418970080451866 2886 720198
SGTC_3158 9100007 49.47 µM -0.204699531490477 0.410305305394552 no 1989 0.418903443236751 2783 19297233
SGTC_3260 9137109 49.47 µM -0.206863414432796 0.409432343323342 no 1990 0.41805826476185 2883 17478346
SGTC_928 2764-0428 58.7 µM -0.209861033917743 0.408223774458649 no 1991 0.416888067693549 2898 662578
SGTC_509 pifithrin 175 µM -0.210636681869446 0.407911193288771 no 1992 0.416585393215397 2793 4817 A p53 inhibitor.
SGTC_274 sirtinol 40.1 µM -0.210694244497041 0.407887998251124 no 1993 0.416562933011475 2810 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3157 9099274 49.47 µM -0.211132414942788 0.407711446711266 no 1994 0.416391973419721 2843 17217662
SGTC_1059 3448-6867 171 µM -0.211956305888499 0.407379528006731 no 1995 0.416070561318148 2738 3934407
SGTC_710 3448-4187 58 µM -0.212853408570363 0.407018190309416 no 1996 0.415720652062556 2807 3946412
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.213011280966512 0.406954610173256 no 1997 0.415659081833357 2801 6708561
SGTC_1271 0832-2808 169 µM -0.213119927727217 0.406910856159571 no 1998 0.41561671080299 2937 3663794
SGTC_2133 5320837 200 µM -0.213850871818272 0.406616521994551 no 1999 0.415331676249969 2940 2841355
SGTC_2334 9017922 200 µM -0.216268231656548 0.405643484033495 no 2000 0.414389335276322 2948 3163164
SGTC_1813 st051246 8.6015 µM -0.216400728049119 0.405590168252202 no 2001 0.414337699406545 2852 5291959
SGTC_2524 avocatin b 10.57 µM -0.216889405449127 0.405393542445576 no 2002 0.414147267159468 2888 6710748
SGTC_2265 7929201 200 µM -0.217027343036898 0.405338045753445 no 2003 0.414093518038204 2756 1265108
SGTC_1483 3453-0561 55.9 µM -0.217536873347789 0.405133061961715 no 2004 0.413894987081417 2883 4546991
SGTC_1161 k007-0610 110 µM -0.218244060060357 0.404848604231626 no 2005 0.413619478702516 2872 5843850
SGTC_1844 rapamycin 4 nM -0.219829018531787 0.404211255708768 no 2006 0.413002159430139 2766 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.224322482405254 0.402405716779651 no 2007 0.41125319175166 2828 756377
SGTC_801 0866-0028 10.1 µM -0.224452437833843 0.402353529568857 no 2008 0.411202635928511 2784 6849771
SGTC_1319 1306-0155 43.7 µM -0.22449363138061 0.402336987519558 no 2009 0.411186610944464 2801 3122360
SGTC_1106 tegaserod maleate 11.7 µM -0.224808065455364 0.402210726323048 no 2010 0.411064295673954 2851 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2296 7971656 126.45 µM -0.225004832415617 0.402131719618074 no 2011 0.410987757463781 2874 666570
SGTC_484 loperamide 105 µM -0.225430720833146 0.401960728790387 no 2012 0.410822107432524 2766 3955 An opioid-receptor agonist.
SGTC_1411 3909-8223 150 µM -0.225657064441122 0.401869861257667 no 2013 0.4107340771676 2910 X1411
SGTC_2416 tofa 880 nM -0.225861775465507 0.401787682874444 no 2014 0.41065446418681 2823 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1079 idarubicin 2.36 µM -0.226409735566383 0.401567733318798 no 2015 0.410441378314544 2827 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2190 6049624 200 µM -0.226410367021316 0.401567479872639 no 2016 0.410441132775178 2812 2265554
SGTC_760 0568-0725 82.9 µM -0.226417746064284 0.401564518159829 no 2017 0.410438263458944 2957 3916171
SGTC_2326 6164455 177.58 µM -0.227124463321921 0.401280890590636 no 2018 0.410163481049105 2885 2888790
SGTC_2640 pentamidine 10.38 µM -0.227398689091211 0.401170849276568 no 2019 0.410056869772073 2917 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2418 pentamidine 31.67 µM -0.227887680707523 0.4009746461832 no 2020 0.409866780067076 2770 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_503 tyrphostin 8 294 µM -0.228231624104593 0.400836657223792 no 2021 0.409733088827358 2931 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3102 9121669 49.47 µM -0.229733928532937 0.400234082881079 no 2022 0.409149264390663 2836 41905072
SGTC_581 0958-0271 211 µM -0.230000008135908 0.400127383054061 no 2023 0.409045881696961 2809 4591145
SGTC_2339 9000433 200 µM -0.230650792158092 0.399866445428617 no 2024 0.408793052442052 2864 2988954
SGTC_2748 diazoxide 86.69 µM -0.231989205031888 0.399329937559419 no 2025 0.408273199122657 2896 3019 A potassium channel activatior.
SGTC_833 3852-0053 558 µM -0.232197086601757 0.39924662447319 no 2026 0.408192470241613 2977 3123681
SGTC_3342 9147791 14.508 µM -0.232917147112076 0.398958079971235 no 2027 0.407912871561241 2805 1838168
SGTC_939 1165-0479 45.3 µM -0.233517335903944 0.39871761295183 no 2028 0.407679854757373 2901 1377347
SGTC_2050 5263056 171 µM -0.2338387845145 0.398588839629293 no 2029 0.4075550692362 2972 763468 YGL055W OLE1
SGTC_500 h-89 112 µM -0.234879618429046 0.398171954113251 no 2030 0.407151084612042 3014 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2189 6047310 154.431 µM -0.236362037756635 0.397578400986096 no 2031 0.40657587558161 2791 711535
SGTC_3076 9116187 49.47 µM -0.236370518117119 0.397575006173692 no 2032 0.406572585606771 2934 27241210
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.237297626843152 0.397203917817594 no 2033 0.406212951519319 2845 279621
SGTC_1920 st075728 45.7 µM -0.237659079681762 0.397059266404638 no 2034 0.406072762023307 3030 3400306
SGTC_1499 4480-0877 67.3 µM -0.237854005381811 0.396981264101095 no 2035 0.405997165080818 2817 2861909
SGTC_3273 9137859 49.47 µM -0.238001616525348 0.396922198135138 no 2036 0.405939920209648 2817 2377234
SGTC_2585 alliin 100 µM -0.238344101867228 0.39678516320441 no 2037 0.405807109196211 3031 87310 A garlic compound which reacts with lipids.
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.239657645906287 0.39625970745225 no 2038 0.405297835886475 3012 1273210
SGTC_616 4092-0450 108 µM -0.240057011287224 0.396099987008754 no 2039 0.405143029931222 2888 787165
SGTC_718 1130-0073 349 µM -0.240288607817714 0.396007371293043 no 2040 0.405053262992625 2993 6740020
SGTC_1250 0485-0349 40.2 µM -0.242965133852829 0.394937452676247 no 2041 0.404016203692956 2873 6842794 YDL195W SEC31
SGTC_1437 4092-1038 11.6 µM -0.243974413938029 0.39453420664423 no 2042 0.40362531797719 2855 3977136
SGTC_1480 1070-0044 41.2 µM -0.244223796220967 0.394434586266435 no 2043 0.403528749122907 2915 3124987
SGTC_1012 4112-3522 18 µM -0.244301040876421 0.394403730856434 no 2044 0.403498838696457 2996 3112398
SGTC_3016 9080866 49.47 µM -0.244485981666577 0.394329858872812 no 2045 0.40342722881369 2872 17066299
SGTC_2001 4023502 57.655 µM -0.245531385580233 0.393912358594853 no 2046 0.40302250479219 2967 108941 YCR052W RSC6
SGTC_2734 clemastine 41.6 µM -0.245755128266381 0.393823018872828 no 2047 0.402935897169891 2837 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_846 0335-0850 148 µM -0.2471403058621 0.393270046550878 no 2048 0.402399820714561 2870 6819598
SGTC_902 1120-0002 2.07 µM -0.247488810761622 0.393130954870134 no 2049 0.402264974968193 2825 3280475
SGTC_882 0843-0131 351 µM -0.248798623717417 0.392608317951042 no 2050 0.401758277877052 2832 5425421
SGTC_1139 k015-0024 46.9 µM -0.249481299398618 0.392335995807181 no 2051 0.401494252297512 2960 2766652
SGTC_177 1327-0068 8.361 µM -0.250395870372037 0.391971252311216 no 2052 0.401140611444078 2869 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1716 st033144 30.6155 µM -0.250592177058464 0.391892974864038 no 2053 0.401064715290902 3011 674617
SGTC_2140 5586273 200 µM -0.251095352727079 0.39169235315607 no 2054 0.400870194410679 2832 854421
SGTC_2753 fluvastatin 17.09 µM -0.251428168890394 0.391559671489452 no 2055 0.40074154570194 2931 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1005 4092-0690 4.4 µM -0.251716205715519 0.391444851893938 no 2056 0.400630214950006 2910 1529343
SGTC_985 1493-0307 8.71 µM -0.254661075308481 0.390271488203202 no 2057 0.399492441293487 2984 3278274
SGTC_2125 5246583 200 µM -0.254703669699998 0.390254524054146 no 2058 0.399475990848934 2963 835267
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.255228354872639 0.39004557384637 no 2059 0.399273366040645 2875 6708514
SGTC_3261 9137475 49.47 µM -0.255719238336736 0.38985011356471 no 2060 0.399083819463755 2838 17027690
SGTC_2849 9019321 12.99 µM -0.256606039875313 0.389497077015205 no 2061 0.398741455976785 2982 16489627
SGTC_3079 9117512 49.47 µM -0.257055835753718 0.389318047672661 no 2062 0.398567835062333 2826 7185044
SGTC_2511 berberine 10.47 µM -0.257169825352184 0.389272680859968 no 2063 0.398523838338836 2867 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2436 5633522 8.09 µM -0.257403424618632 0.389179715214833 no 2064 0.398433679736126 3014 5724242
SGTC_1558 st069300 45.6 µM -0.258203283109506 0.38886144311085 no 2065 0.398125012132063 2948 24208000
SGTC_270 tamoxifen 5.46 µM -0.258798603851747 0.388624607123313 no 2066 0.397895317576504 3058 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2900 5328528 85.29 µM -0.260693093608516 0.387871199599311 no 2067 0.397164596225726 2865 795359
SGTC_1540 guanosine 70.6 µM -0.263372349407966 0.386806424307677 no 2068 0.396131800229576 2835 6802 Guanosine is a purine nucleoside
SGTC_3127 9126946 49.47 µM -0.264018518354378 0.386549754485459 no 2069 0.395882824652847 2952 27243249
SGTC_1829 berberine 14.4 µM -0.266858944785761 0.385422076405304 no 2070 0.394788883964635 3048 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_739 1486-1183 203 µM -0.267431811068488 0.385194759679695 no 2071 0.39456835468939 3004 4346692
SGTC_2421 5690543 90.72 µM -0.270042339981465 0.384159386876708 no 2072 0.393563840285108 2978 3397993
SGTC_289 k017-0060 526 µM -0.270391625292511 0.384020917866779 no 2073 0.393429491142721 2886 5512909
SGTC_1553 gossypol 38.6 µM -0.272211518845504 0.383299687793452 no 2074 0.392729692697319 2860 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1662 st014054 52 µM -0.278498599816005 0.380811221112462 no 2075 0.390314819864016 2904 2838777
SGTC_1996 st072960 66.8 µM -0.278820824288545 0.380683814354836 no 2076 0.390191166244278 3024 1719405
SGTC_3196 9111891 49.47 µM -0.279281647903633 0.380501628326211 no 2077 0.390014344519821 2863 18891510
SGTC_2987 9018338 71.43 µM -0.279462781133301 0.380430024788078 no 2078 0.389944848472045 2924 5055682
SGTC_2078 5212016 200 µM -0.279824360974515 0.380287101391215 no 2079 0.389806130335953 2880 1899708
SGTC_3118 9124250 49.47 µM -0.280884696907688 0.379868071625048 no 2080 0.389399419218756 2953 1504786
SGTC_712 r015-0009 80.6 µM -0.281450455477558 0.37964454949682 no 2081 0.389182461761727 3005 6813872 YLR060W FRS1
SGTC_667 1498-1044 59 µM -0.282872761854794 0.379082796852313 no 2082 0.388637187530416 2937 6739982
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.283674142084426 0.378766396905236 no 2083 0.388330056321773 2994 5379071
SGTC_1547 harmine 94.2 µM -0.284639452848415 0.378385381979994 no 2084 0.387960190989318 2934 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2608 thymoquinone 42.66 µM -0.284693402075453 0.37836409132649 no 2085 0.387939522974168 2967 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.286078099677917 0.377817757458601 no 2086 0.387409152411427 2861 688667
SGTC_2490 carminic acid 95.39 µM -0.28615810925601 0.377786197052755 no 2087 0.387378513340096 2867 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_814 3342-0569 96 µM -0.286700860726925 0.377572126024031 no 2088 0.387170689239967 2921 4346283
SGTC_3235 9132602 49.47 µM -0.286855211453709 0.377511254161227 no 2089 0.387111592952507 3019 4912240
SGTC_1660 st012960 28.1 µM -0.2869210479447 0.37748529090812 no 2090 0.387086386920629 3000 24207266
SGTC_56 0957-0365 83.25 µM -0.288080195844859 0.377028260575548 no 2091 0.386642675872982 3042 6752360
SGTC_1666 st014829 29 µM -0.288421655055743 0.376893662408107 no 2092 0.386511996682093 2864 3858230
SGTC_279 1273-0055 2.93 µM -0.289081073293388 0.376633771852357 no 2093 0.386259668446232 2979 2847562
SGTC_2158 5657123 3.6195 µM -0.289109927401886 0.376622401118872 no 2094 0.386248628438354 2886 2858827
SGTC_512 prima-1 270 µM -0.289503664730987 0.37646724908961 no 2095 0.386097987929949 3059 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1104 tacrolimus 29.8 µM -0.290214599681607 0.376187156031935 no 2096 0.385826033850939 2946 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_278 4092-0821 23.9 µM -0.290264535580178 0.376167484812385 no 2097 0.385806933969689 2986 877900
SGTC_1809 st050081 57.6 µM -0.290694246922942 0.375998222172701 no 2098 0.385642585989762 3094 5036894
SGTC_352 k048-0007 5.11 µM -0.291014024159278 0.375872277887163 no 2099 0.385520296877273 3007 6811911
SGTC_3119 9125183 49.47 µM -0.291970088014697 0.3754958109819 no 2100 0.385154747148139 2964 22695334
SGTC_322 k048-0136 19.3 µM -0.293631607916438 0.374841840546426 no 2101 0.384519710151737 3006 6823282
SGTC_652 0437-0092 114 µM -0.294473908504284 0.374510450245169 no 2102 0.384197899005631 2933 3091274
SGTC_280 3448-3607 3.04 µM -0.294583723977886 0.374467251847919 no 2103 0.384155948549795 3030 626179
SGTC_2829 7992743 58.44 µM -0.295869316333356 0.37396165238235 no 2104 0.383664942267327 3099 16462845
SGTC_371 0195-0006 7.36 µM -0.296014471456746 0.373904579186275 no 2105 0.383609514889806 2846 3928593
SGTC_2155 5570423 76 µM -0.296166909427092 0.373844645440971 no 2106 0.383551309126314 2945 797402
SGTC_455 paf C-16 10 µM -0.296337854804977 0.373777438801764 no 2107 0.383486039759822 2911 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_974 1326-0144 138 µM -0.298128962696397 0.373073501464291 no 2108 0.382802368535121 2958 5411856
SGTC_44 0929-0055 61.211 µM -0.2982569660192 0.373023210063754 no 2109 0.382753523234818 2902 1379590
SGTC_967 1306-0166 352 µM -0.298609581902959 0.37288468151907 no 2110 0.382618976774529 3094 4437607
SGTC_3299 9121982 43.1275 µM -0.298716078955471 0.372842846357496 no 2111 0.382578343835978 2956 17594604 YPL160W CDC60
SGTC_1467 k284-1082 293 µM -0.300279031881132 0.372229045414764 no 2112 0.381982162906874 3033 3334705
SGTC_1447 4239-0816 81.9 µM -0.302575864922153 0.371327625118528 no 2113 0.381106554884273 2942 1341554
SGTC_2402 5553605 200 µM -0.303752145712453 0.370866252081362 no 2114 0.380658363618155 3135 6758546
SGTC_3110 9122132 49.47 µM -0.303753695448816 0.370865644349989 no 2115 0.380657773236822 3097 918317
SGTC_773 4358-1457 44.6 µM -0.304357588305367 0.370628851420416 no 2116 0.380427737809543 3119 1186886
SGTC_356 1634-0012 32.5 µM -0.30471863179577 0.370487305755767 no 2117 0.380290228976585 3065 735457
SGTC_2698 st077697 67.5 µM -0.305232822962942 0.370285749420764 no 2118 0.380094417669506 2980 3154499
SGTC_1248 0469-0687 58.6 µM -0.305435186088456 0.370206435436075 no 2119 0.380017363338331 3048 4017482
SGTC_2646 retinol 96.75 µM -0.305666272240245 0.370115870528762 no 2120 0.379929377890681 3012 445354 A vitamin A analog and teratogen.
SGTC_2457 5731572 11.68 µM -0.305821450960888 0.370055058522053 no 2121 0.379870297486403 3075 2865357
SGTC_3125 9127534 49.47 µM -0.307198822714943 0.369515431569449 no 2122 0.379346020785887 3016 1639235
SGTC_2598 perillyl alcohol 100 µM -0.308221464512764 0.369114946915345 no 2123 0.378956910343473 3105 10819 An apoptosis inducer.
SGTC_2173 5763948 167 µM -0.30884201498841 0.368871997563774 no 2124 0.378720853536605 2928 2867177
SGTC_1876 myriocin 605 nM -0.309562474345331 0.368589998989016 no 2125 0.378446848239834 3125 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_694 1315-0438 43.2 µM -0.309927195082739 0.36844726879962 no 2126 0.378308160838646 2989 6793154
SGTC_2876 9059903 25.97 µM -0.310167735693409 0.368353145320362 no 2127 0.378216702305138 2920 6916095
SGTC_475 α-linolenic acid 10 µM -0.310830463973762 0.368093860796108 no 2128 0.37796475456707 3178 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2449 5812982 45.77 µM -0.314011488281403 0.366850161163424 no 2129 0.376756156691223 3044 776185
SGTC_847 0342-0274 5.54 µM -0.315325240296608 0.366336924191494 no 2130 0.376257361402578 3083 18097
SGTC_1774 st048371 48.465 µM -0.315899450361571 0.366112675398206 no 2131 0.376039414563771 2948 4242727
SGTC_1202 1988-0068 29.6 µM -0.315967691225254 0.366086028030614 no 2132 0.376013515728027 2957 2850480
SGTC_546 peri-Naphthalide 147 µM -0.316377396715467 0.365926055760936 no 2133 0.375858035665716 3009 223824 A penicillin ester.
SGTC_2733 amorolfine 100 µM -0.317967453698667 0.365305428276859 no 2134 0.375254812433165 3008 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_147 4466-0538 29.23 µM -0.318642705167355 0.365041972192766 no 2135 0.374998733032401 3187 6742687 YHR072W ERG7
SGTC_2934 9036370 36.88 µM -0.319535442586089 0.364693759585353 no 2136 0.374660259800007 3066 6462800
SGTC_945 3381-0768 11.3 µM -0.320184945386573 0.364440490855293 no 2137 0.374414067404202 3120 1126236 YIL048W NEO1
SGTC_1679 SEC14.276 6.7 µM -0.321946790193367 0.36375377095565 no 2138 0.37374650262717 3094 1005053 YMR079W SEC14
SGTC_2353 9059630 146.67 µM -0.322188668578565 0.363659527342478 no 2139 0.373654884173306 3078 4779114
SGTC_2848 9016370 25.97 µM -0.322820666069653 0.363413319702981 no 2140 0.373415530504003 3089 7894410
SGTC_2136 5328288 199.296 µM -0.323248000464399 0.363246874748792 no 2141 0.37325371566663 2993 262395
SGTC_2812 7970281 58.44 µM -0.324192092937788 0.362879246262243 no 2142 0.372896304009141 3121 2233435
SGTC_1443 4112-3303 14 µM -0.324198985719882 0.362876562685244 no 2143 0.372893694962498 2980 704433
SGTC_1895 st058434 18.3 µM -0.324653271493184 0.362699709789567 no 2144 0.372721752180396 3141 5393175
SGTC_1218 1348-1416 30.7 µM -0.324666207613953 0.362694674202253 no 2145 0.372716856354659 2951 6787668
SGTC_2641 levomentholum 100 µM -0.325859255393467 0.362230363889001 no 2146 0.372265422002575 3037 16666
SGTC_154 3389-1638 511.116 µM -0.326000510225348 0.362175403738471 no 2147 0.372211984547861 3052 5238686
SGTC_2779 methotrexate 400 µM -0.327034034125478 0.361773361501072 no 2148 0.37182107188484 3069 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2452 5863136 48.41 µM -0.329173598350043 0.360941553154666 no 2149 0.3710122387026 2945 2184096
SGTC_3047 9092122 49.47 µM -0.329193696746958 0.360933742517382 no 2150 0.371004643471327 3049 17173831
SGTC_2834 9001755 58.44 µM -0.329623744168501 0.360766631426397 no 2151 0.370842139589015 3015 2989575
SGTC_2775 cyproheptadine 69.59 µM -0.330220506843983 0.360534780897604 no 2152 0.370616676456145 3083 2913 A selective serotonin reuptake inhibitor.
SGTC_1293 1000-1278 195 µM -0.331155549774675 0.36017160693941 no 2153 0.370263496897711 3114 678847
SGTC_1907 st060210 83.7 µM -0.331638338755574 0.359984139367121 no 2154 0.370081183138141 3139 688793
SGTC_430 0958-0115 16.4 µM -0.331762972895724 0.359935749239353 no 2155 0.370034122762262 3010 6833180
SGTC_1619 st003326 88.7 µM -0.333966608140784 0.35908054289066 no 2156 0.369202378129213 3146 2849032
SGTC_2516 gossypol 71.55 µM -0.334163968078682 0.359003984062247 no 2157 0.369127915988747 3132 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2202 7226349 200 µM -0.335784449574346 0.35837558979041 no 2158 0.368516708730627 2980 844334
SGTC_1289 0976-0073 69.1 µM -0.337615316653418 0.357666072944798 no 2159 0.367826549124108 3109 3391136
SGTC_2701 st077767 14.721 µM -0.337671674468647 0.357644240358566 no 2160 0.367805311362114 3032 5721188
SGTC_2720 fluspirilene 36.88 µM -0.337891348304751 0.357559144842772 no 2161 0.367722533788602 3083 3396 An atypical antipsychotic.
SGTC_3337 9144342 33.5465 µM -0.339883363304653 0.356787817500566 no 2162 0.366972182884933 3101 17682949
SGTC_1905 st060207 84.5 µM -0.340205076178754 0.356663301988353 no 2163 0.366851047854218 2973 1948547
SGTC_3241 9133421 49.47 µM -0.340323664920253 0.356617407341716 no 2164 0.366806398801157 3056 17018221
SGTC_1311 1190-0148 100 µM -0.341941019767442 0.355991687523648 no 2165 0.366197639461671 3133 1961333
SGTC_305 1682-2595 20.8 µM -0.343252373161252 0.355484637587989 no 2166 0.36570430361964 3071 226033
SGTC_2284 7945075 39.21 µM -0.343283599149484 0.35547256681199 no 2167 0.365692558994326 3142 1245402
SGTC_2345 9052315 157.45 µM -0.344273870195048 0.355089841051917 no 2168 0.365320166566925 3100 6469265
SGTC_193 1273-0060 1.558 µM -0.344435111199752 0.355027537509003 no 2169 0.365259543732515 3043 2847393 YHR072W ERG7
SGTC_2712 st079126 47.7 µM -0.345036666008449 0.354795130878587 no 2170 0.365033402960959 2998 3152970
SGTC_1519 esterone 74 µM -0.345367102603709 0.354667491920609 no 2171 0.364909202846842 2991 698 A steroid.
SGTC_272 doxorubicin 8.13 µM -0.345961042307539 0.354438109675086 no 2172 0.364685996328557 3021 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_448 monastrol 171 µM -0.346381197816003 0.354275875558586 no 2173 0.364528126765921 3060 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3250 9135583 49.47 µM -0.34706666012286 0.354011255632387 no 2174 0.3642706199423 3153 7699353
SGTC_1670 st016595 4.04 µM -0.347227965389009 0.353948994634526 no 2175 0.364210031480826 3072 597879
SGTC_2414 st077232 92.9 µM -0.34728814550556 0.353925767167353 no 2176 0.36418742787607 2965 729801
SGTC_3123 9126162 49.47 µM -0.347350316405449 0.353901771896801 no 2177 0.364164077030755 2990 25239884
SGTC_1573 oleylamine 1.06 µM -0.347352847893936 0.353900794864348 no 2178 0.364163126236542 3003 5356789 An amine of the fatty acid oleic acid.
SGTC_1973 st070275 50.2 µM -0.347515048660835 0.353838195197901 no 2179 0.364102207477264 3063 17118334
SGTC_53 0973-0023 39.979 µM -0.349163557475668 0.353202195117034 no 2180 0.36348326171831 3170 674768
SGTC_601 0986-0029 62.9 µM -0.349303034066379 0.35314840337143 no 2181 0.36343091044305 3033 24747981
SGTC_3131 9127911 49.47 µM -0.3493923848689 0.353113945111709 no 2182 0.36339737476868 3248 45595681
SGTC_930 2810-3379 265 µM -0.350741273351362 0.352593890896305 no 2183 0.362891229260347 3227 1015764
SGTC_2364 9055074 200 µM -0.350742763641655 0.352593316477764 no 2184 0.362890670188667 3099 6470630
SGTC_1734 st037168 69.4 µM -0.351694775639031 0.352226441042823 no 2185 0.362533589505822 3104 708907
SGTC_2253 7938677 135.83 µM -0.352026862152422 0.352098497686115 no 2186 0.362409058595308 3203 2301972
SGTC_603 3794-0023 45.9 µM -0.353794218273186 0.351417868273882 no 2187 0.361746553386661 3130 3802260
SGTC_2485 5633444 17.78 µM -0.354618752664404 0.351100493236552 no 2188 0.361437612739649 3103 5724239
SGTC_1818 st052136 56.3 µM -0.354674589401473 0.35107900463204 no 2189 0.361416694816483 3125 674169
SGTC_723 4182-0001 115 µM -0.35472891387869 0.351058098473315 no 2190 0.361396343823555 3051 744821 YLR208W SEC13
SGTC_2468 5987765 72.9 µM -0.355377337356085 0.350808594874095 no 2191 0.361153462222077 3075 26772094
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.355674877582555 0.350694127394929 no 2192 0.36104203056211 3084 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2175 5807670 165.306 µM -0.357854155827599 0.349856145318992 no 2193 0.360226230050006 3164 241186
SGTC_570 0987-0065 62.6 µM -0.358416325735684 0.349640096610408 no 2194 0.360015887969179 2992 3104428
SGTC_191 3914-0123 66.505 µM -0.359667056252048 0.349159600464461 no 2195 0.3595480654391 3006 3144412
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.362199758894236 0.348187346943259 no 2196 0.358601379858714 3009 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2882 9058044 58.44 µM -0.362806337539826 0.347954641350673 no 2197 0.358374778665415 3120 18076804
SGTC_3029 9088683 49.47 µM -0.363482397715993 0.3476953475862 no 2198 0.358122279833033 3181 25236615
SGTC_2984 9022109 38.96 µM -0.364820822097679 0.347182223148876 no 2199 0.357622580506254 3171 6459207
SGTC_357 1325-0123 420 µM -0.364885302346649 0.347157509807645 no 2200 0.357598513026354 3163 1098503
SGTC_1446 4239-0190 62 µM -0.365193574841776 0.347039367209763 no 2201 0.357483457058867 3058 1340085
SGTC_2565 isoliquiritigenin 100 µM -0.366392162880682 0.346580160729621 no 2202 0.357036233450376 3168 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_488 nitrendipine 139 µM -0.367738870412505 0.346064475137042 no 2203 0.356533976982258 3060 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_483 fpl-64176 144 µM -0.369474514940481 0.345400277471745 no 2204 0.355887032799032 3097 3423
SGTC_576 1073-0113 22.7 µM -0.369938450967882 0.345222818608777 no 2205 0.355714175449008 3161 5439563
SGTC_1545 lovastatin 49.4 µM -0.370067731872741 0.345173373794333 no 2206 0.355666012120298 3137 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_3355 9151058 44.0485 µM -0.370368907394386 0.345058196363434 no 2207 0.355553818752072 3123 17015728
SGTC_3278 9139605 49.47 µM -0.371406457899422 0.344661519745664 no 2208 0.355167408156964 3231 7958859
SGTC_506 n9-isopropylolomoucine 153 µM -0.37236955308339 0.344293461686948 no 2209 0.354808859871958 3183 6610355
SGTC_1529 apigenin 74 µM -0.37431066788267 0.343552090298359 no 2210 0.354086598099832 3299 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2809 7964133 12.99 µM -0.374438957291127 0.343503113788094 no 2211 0.354038881853622 3097 1253665
SGTC_309 k408-0051 1.48 µM -0.375365076069064 0.343149631288354 no 2212 0.353694487226632 3120 3640463
SGTC_2142 5622915 118.518 µM -0.376165988221973 0.342844048469456 no 2213 0.353396749542118 3104 5322196
SGTC_629 3448-6466 76.7 µM -0.376245315080449 0.342813787414245 no 2214 0.353367264800795 3102 573744
SGTC_3234 9132280 49.47 µM -0.377441551422652 0.342357577904824 no 2215 0.352922746398284 3137 17612295
SGTC_2750 bromebric acid 70.15 µM -0.3775178041573 0.342328505133578 no 2216 0.352894417872022 3226 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1744 st037937 38.9 µM -0.377711526349595 0.342254649152508 no 2217 0.352822452131331 3264 1016152
SGTC_3347 9188721 44.724 µM -0.377827316011417 0.342210507585948 no 2218 0.352779440013607 3134 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1199 1638-0010 4.46 µM -0.378773297477909 0.341849959441809 no 2219 0.352428108995277 3062 3111136
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.378816562414812 0.341833473037426 no 2220 0.352412043702725 3106 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1477 0139-0234 16 µM -0.379266272987861 0.341662125570665 no 2221 0.352245071146279 3119 620880
SGTC_796 1234-0020 70.7 µM -0.380924870235108 0.341030453729045 no 2222 0.351629498763126 3060 46495034
SGTC_2187 6125751 200 µM -0.381661863428549 0.340749914850163 no 2223 0.351356095519483 3112 874498
SGTC_2297 7971671 152.32 µM -0.381854520401114 0.340676593852885 no 2224 0.351284638004986 3252 909016
SGTC_3070 9117005 49.47 µM -0.382852378482704 0.340296927446528 no 2225 0.350914611212698 3162 8779016
SGTC_2788 5282734 71.43 µM -0.383207106654253 0.340161998957604 no 2226 0.350783104571638 3230 743706
SGTC_861 0443-0273 110 µM -0.383320320895233 0.340118939793611 no 2227 0.35074113697169 3168 6149169
SGTC_173 1273-0061 2.693 µM -0.383727339978249 0.339964154043989 no 2228 0.350590273348957 3176 2847414 YPL266W DIM1
SGTC_648 0375-0473 33.3 µM -0.386646630302081 0.338854765694574 no 2229 0.349508915839986 3084 1713139
SGTC_1910 st062352 60.4 µM -0.387434513874844 0.338555593147511 no 2230 0.349217278346246 3006 2245730
SGTC_1122 capsaicin 818.572 nM -0.387586244616685 0.338497990142142 no 2231 0.34916112496858 3192 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1600 coumarin 106 71.1 µM -0.388468597975904 0.338163088736423 no 2232 0.348834644081169 3240 100336 A hepatotoxic, DNA x-linker.
SGTC_1520 flindersine 88 µM -0.389842389828414 0.337641914412604 no 2233 0.348326548098503 3332 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_906 1165-0455 526 µM -0.391242030197743 0.337111253987106 no 2234 0.347809171834966 3091 3252859
SGTC_1724 st037281 8.293 µM -0.391488304824863 0.337017914775342 no 2235 0.347718165838357 3051 574124 YDL195W SEC31
SGTC_2118 5526350 200 µM -0.392768452715399 0.336532894610602 no 2236 0.347245253535058 3178 743594
SGTC_1806 st050005 60.3 µM -0.393909866961576 0.336100666811013 no 2237 0.346823792675636 3104 5194765
SGTC_1051 3253-3903 78 µM -0.396140644736629 0.335256547416342 no 2238 0.346000637775389 3047 5509239
SGTC_1992 st073643 23.3 µM -0.396330187915447 0.335184863117965 no 2239 0.345930729986778 3085 3161292
SGTC_1630 st005209 31.3 µM -0.398196108344459 0.334479501904961 no 2240 0.345242817191986 3228 3367314
SGTC_735 3076-0345 636 µM -0.398875083755438 0.33422297820212 no 2241 0.344992624583969 3262 2888990
SGTC_716 1683-5115 658 µM -0.398922401994961 0.334205103781852 no 2242 0.344975191021986 3156 723597
SGTC_778 3456-2434 196 µM -0.40005660070962 0.333776773883451 no 2243 0.344557414274373 3208 5539063
SGTC_753 1322-0200 289 µM -0.403417761848088 0.332508705426536 no 2244 0.343320461170105 3237 5403907
SGTC_3233 9132340 49.47 µM -0.403470306041035 0.332488897189809 no 2245 0.343301137466501 3112 17682950
SGTC_2372 9071633 200 µM -0.404578700944337 0.332071160885231 no 2246 0.342893608611912 3243 21321366
SGTC_908 3448-7491 47.7 µM -0.405328756312087 0.331788595331021 no 2247 0.342617935795839 3090 1203031
SGTC_2909 7941780 10.49 µM -0.405477149064864 0.331732703214811 no 2248 0.342563405949948 3272 1243215
SGTC_2737 bleomycin 30.5 nM -0.405891418424731 0.331576688526484 no 2249 0.342411191865269 3175 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1370 2001-0092 44.6 µM -0.406767134780919 0.331246988131958 no 2250 0.342089513576212 3333 790957
SGTC_1037 k284-1091 78.7 µM -0.40943499922139 0.330243364845888 no 2251 0.341110229690676 3133 3334711
SGTC_2200 6600604 21.907 µM -0.409634913242161 0.330168208289565 no 2252 0.341036890919804 3123 2904777
SGTC_661 1304-0007 33.6 µM -0.409814491157174 0.330100702820272 no 2253 0.340971017601328 3161 3117130
SGTC_1050 3232-1156 69.3 µM -0.411594632334339 0.329431826093149 no 2254 0.340318283277528 3164 700529
SGTC_1402 3909-7673 35.9 µM -0.41212795374068 0.329231540046807 no 2255 0.340122820326863 3122 5328014
SGTC_376 3970-0862 59.1 µM -0.413077219813851 0.328875169421999 no 2256 0.339775019451144 3232 3135186
SGTC_2594 a-mangostin 100 µM -0.415254658722972 0.328058309738911 no 2257 0.338977744785892 3264 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3130 9127414 49.47 µM -0.415369843357155 0.328015121418398 no 2258 0.338935589685244 3213 1494646
SGTC_1930 st074634 34.3 µM -0.415998648734636 0.327779392258839 no 2259 0.338705496000718 3090 684253 YOR116C RPO31
SGTC_892 0929-0076 29 µM -0.419211681598052 0.326575949891953 no 2260 0.337530717778161 3161 5751038
SGTC_2367 9070478 135.38 µM -0.420202435193238 0.326205225861673 no 2261 0.337168787972329 3131 572802
SGTC_1094 duloxetine 25.4 µM -0.421771529021646 0.325618447563872 no 2262 0.336595894426712 3124 60834 A selective serotonin reuptake inhibitor.
SGTC_5 0352-0601 109.883 µM -0.42178172517261 0.32561463602214 no 2263 0.336592172937188 3181 762456
SGTC_2299 7976368 114.88 µM -0.422017562930589 0.325526479856854 no 2264 0.336506099064482 3255 2979718
SGTC_684 1140-0066 328 µM -0.424229352382292 0.324700188353119 no 2265 0.335699278138486 3225 6813534
SGTC_2941 9056145 11.23 µM -0.424269124643997 0.324685337907538 no 2266 0.335684776850301 3201 2119517
SGTC_2031 5180455 200 µM -0.42466676484793 0.324536879548451 no 2267 0.335539807472935 3141 29949
SGTC_480 am 92016 50 µM -0.425825711135218 0.324104347831499 no 2268 0.335117425211104 3212 2129 K+ channel blocker.
SGTC_1722 st034304 3.6505 µM -0.425986276227593 0.324044441847483 no 2269 0.335058923094871 3161 4036148 YLR033W RSC58
SGTC_549 1661-1316 519 µM -0.426476394556944 0.323861609484521 no 2270 0.334880372548623 3298 2857282
SGTC_1342 1486-1464 234 µM -0.427497376467109 0.323480881753208 no 2271 0.334508547802264 3164 3253938
SGTC_2843 9000894 45.46 µM -0.427596600183662 0.323443890724429 no 2272 0.334472420809182 3194 2242070
SGTC_835 0312-0010 67.2 µM -0.428408795854329 0.323141166308277 no 2273 0.334176760978011 3125 1626196
SGTC_2514 salinomycin 42.74 µM -0.429593834372926 0.3226996846907 no 2274 0.333745561455152 3311 23682228 A polyether potassium ionophore.
SGTC_2011 4012611 177 µM -0.430273749800747 0.322446497505218 no 2275 0.333498259930948 3132 2049887
SGTC_2905 7799065 20.05 µM -0.430804109150092 0.322249059222299 no 2276 0.333305405749505 3307 1296806
SGTC_2032 5185112 25.99 µM -0.43096630561777 0.322188687921942 no 2277 0.333246435162232 3184 5718189
SGTC_1620 st003704 16.5 µM -0.431404284189746 0.322025690942462 no 2278 0.333087217682011 3291 2834414
SGTC_499 genistein 192 µM -0.431804346062169 0.321876834856245 no 2279 0.332941810270776 3232 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_756 0508-1999 28.3 µM -0.433823859992522 0.32112584542139 no 2280 0.332208176878918 3150 6753853
SGTC_3223 9129970 49.47 µM -0.434047056617331 0.321042890893112 no 2281 0.332127135118487 3127 17248386
SGTC_415 dibenzyl ketone 100 µM -0.434127272948429 0.321013079416231 no 2282 0.332098010821988 3227 7593
SGTC_2693 st077581 40.7 µM -0.434131335458497 0.32101156966178 no 2283 0.332096535865682 3281 25238761
SGTC_2413 inermin 26.06 µM -0.437357125392685 0.319813702088809 no 2284 0.330926186322016 3392 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1195 1502-0147 41.1 µM -0.438640181560695 0.319337771881952 no 2285 0.330461138546458 3186 817940
SGTC_2328 6201408 200 µM -0.43888460962154 0.319247138717675 no 2286 0.330372574473274 3269 2890418
SGTC_1320 1313-0481 95.3 µM -0.438907206878827 0.319238760270352 no 2287 0.330364387246759 3337 6813365 YLR208W SEC13
SGTC_401 neomycin 50 µM -0.439272352130336 0.319103387160563 no 2288 0.330232102500372 3202 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1747 st037496 66.6 µM -0.440359592645035 0.318700449005922 no 2289 0.329838342924466 3159 723305
SGTC_2417 cerulenin 830 nM -0.440524715061329 0.318639272332501 no 2290 0.329778557975713 3316 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2137 5261020 140 µM -0.441550648550086 0.318259282136519 no 2291 0.329407201478211 3165 763655
SGTC_2430 5571206 200 µM -0.441732741017974 0.318191857814643 no 2292 0.32934130714838 3335 1731771
SGTC_2073 5212005 126 µM -0.442946450114821 0.317742605427213 no 2293 0.32890223419603 3196 691789
SGTC_1166 k206-0078 225 µM -0.443812051532214 0.317422368305962 no 2294 0.328589237258187 3186 5404595
SGTC_1617 st002906 78 µM -0.445299632593578 0.316872343358681 no 2295 0.328051616675123 3188 5150859
SGTC_1397 3532-0190 20.1 µM -0.4462072735052 0.31653694670824 no 2296 0.3277237647045 3093 5322280
SGTC_3341 9147222 25.867 µM -0.447105021996465 0.316205353900359 no 2297 0.327399616596343 3313 1939759
SGTC_597 k018-0003 82.8 µM -0.447565253078561 0.316035420002744 no 2298 0.327233492377827 3306 6786234
SGTC_2368 9071271 200 µM -0.448546984020074 0.315673059462264 no 2299 0.326879242840498 3215 27209959
SGTC_95 0471-0001 561.058 µM -0.44895422675184 0.315522796612334 no 2300 0.32673233840032 3208 4015405
SGTC_2689 tacrolimus 100 µM -0.449386928853891 0.315363173279568 no 2301 0.326576279443873 3252 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2600 tangeritin 87.95 µM -0.450715423913959 0.31487330829046 no 2302 0.326097332213918 3195 68077 A bioactive flavone.
SGTC_137 0438-0332 85.389 µM -0.452392203211594 0.314255482861055 no 2303 0.325493231397891 3311 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2491 paeonol 100 µM -0.452922864388669 0.31406006390551 no 2304 0.325302143070354 3219 11092 Increases levels of cortical cytochrome oxidase.
SGTC_528 3492-0019 172 µM -0.453453645149523 0.313864653053924 no 2305 0.325111057619136 3296 2869262
SGTC_1382 3002-2117 298 µM -0.454810372924698 0.313365401033016 no 2306 0.324622833531231 3348 1497314
SGTC_3333 9141820 12.094 µM -0.455085972426683 0.313264026989908 no 2307 0.324523694692758 3177 1939433
SGTC_1546 5-methoxyflavanone 78.7 µM -0.456175888231475 0.312863260447665 no 2308 0.324131751315273 3278 147795
SGTC_167 3672-0051 66.205 µM -0.457595194518511 0.312341707076052 no 2309 0.323621648296766 3173 3237971
SGTC_1456 k015-0012 13 µM -0.458352429328961 0.312063599168847 no 2310 0.323349631223799 3384 2989616
SGTC_3247 9135149 49.47 µM -0.458425292696371 0.31203684445078 no 2311 0.323323461915092 3233 8934436 YOR116C RPO31
SGTC_2762 leflunomide 42.06 µM -0.459666352701424 0.311581291683534 no 2312 0.322877862213611 3229 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3168 9103419 49.47 µM -0.459771097608972 0.311542856416029 no 2313 0.322840265420557 3263 16649256
SGTC_3008 9078912 71.4286 µM -0.45977840658621 0.31154017452462 no 2314 0.322837642027849 3225 16648731
SGTC_306 1672-3436 11.6 µM -0.460367198576248 0.311324161259553 no 2315 0.322626337378692 3305 6797378
SGTC_1652 st011932 78 µM -0.462154482561961 0.310668848877453 no 2316 0.321985271003754 3284 1551076
SGTC_1981 st071826 47 µM -0.463159382017678 0.310300663312815 no 2317 0.32162506414047 3275 11838600
SGTC_1357 1503-1303 39.5 µM -0.463491870558026 0.310178884509493 no 2318 0.321505920296073 3240 292895
SGTC_1390 3413-2614 145 µM -0.463921859392759 0.31002142565885 no 2319 0.321351865451123 3264 3421432
SGTC_1857 st056007 79.3 µM -0.464954001260941 0.309643604860324 no 2320 0.32098219884231 3316 619834
SGTC_2546 rhodinyl acetate 100 µM -0.466378885341502 0.309122349172372 no 2321 0.320472161203413 3332 6708682
SGTC_315 k915-0449 187 µM -0.466871776231609 0.308942127583311 no 2322 0.320295809610288 3282 20970215 YNL149C PGA2
SGTC_678 1218-2179 85.9 µM -0.467079102681735 0.308866334071622 no 2323 0.320221642333472 3279 6820081 YOR116C RPO31
SGTC_1457 k015-0032 57.3 µM -0.468124635254857 0.308484236833798 no 2324 0.319847731501724 3295 4302660
SGTC_981 1488-1094 54.9 µM -0.468617661339415 0.308304128889107 no 2325 0.319671475450356 3246 3449522
SGTC_2387 9077560 195.08 µM -0.468658897558523 0.308289066927089 no 2326 0.319656735411498 3212 5303272
SGTC_236 1509-0011 5.31 µM -0.468856698018624 0.308216822719612 no 2327 0.319586034867006 3386 3107280
SGTC_1014 4130-3005 69.3 µM -0.469073813061815 0.308137532648017 no 2328 0.319508438188321 3196 743608
SGTC_968 1309-0633 340 µM -0.469970218799775 0.307810261508328 no 2329 0.319188147455946 3324 3761976
SGTC_755 1995-0008 37.3 µM -0.470442502039168 0.307637895829751 no 2330 0.319019452289404 3328 689533
SGTC_1232 0279-0259 161 µM -0.470669270427933 0.307555148952345 no 2331 0.318938466052385 3255 1560000
SGTC_88 0180-0332 8.668 µM -0.471443773814697 0.307272609612642 no 2332 0.318661931339626 3216 3101745
SGTC_626 0214-0009 33 µM -0.47319779032264 0.306633166176408 no 2333 0.318036037049579 3349 3437874
SGTC_1460 k062-0059 9.15 µM -0.474961358587198 0.305990833420333 no 2334 0.317407257886165 3188 1373085
SGTC_3098 9119039 49.47 µM -0.475986746745799 0.30561763703892 no 2335 0.317041909947289 3329 17161528
SGTC_3019 9081971 49.47 µM -0.476112806716502 0.305571770655189 no 2336 0.316997006816382 3399 16451803
SGTC_3134 9127454 49.47 µM -0.476167270924972 0.305551955028565 no 2337 0.316977607253013 3370 24262820
SGTC_2724 maprotiline 69.64 µM -0.476325615376611 0.305494348052892 no 2338 0.316921209525664 3357 4011 A tricyclic antidepressant.
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.476968139102576 0.305260642215747 no 2339 0.316692404763174 3289 16486 A toxic proline analog.
SGTC_1948 st076329 66.6 µM -0.478686230280556 0.30463610912763 no 2340 0.316080931558001 3276 24208413
SGTC_228 caffeine 993.056 µM -0.480999364634311 0.303796174301831 no 2341 0.315258475145795 3336 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_248 streptozotocin 5.23457 mM -0.481347710673108 0.30366977403741 no 2342 0.315134696627432 3330 5300 DNA alkylating agent.
SGTC_1704 st028805 70.8 µM -0.481481861992737 0.303621102374386 no 2343 0.315087033895955 3307 2876101
SGTC_1054 3429-0080 167 µM -0.482427735296935 0.3032780274066 no 2344 0.314751061212848 3372 1162877
SGTC_1337 1486-1011 40.3 µM -0.483902491993061 0.302743468701957 no 2345 0.31422753587123 3352 X1337
SGTC_2482 5981709 142.65 µM -0.485078540044808 0.302317486372257 no 2346 0.31381031703111 3263 877755
SGTC_1887 st057648 70.8 µM -0.488902328411749 0.300934314918428 no 2347 0.312455423588872 3356 688672
SGTC_2431 5490079 200 µM -0.489323292850635 0.300782214800075 no 2348 0.31230641645959 3296 5722345
SGTC_212 3807-4682 38.772 µM -0.490502691372232 0.300356267066283 no 2349 0.311889112901978 3339 3125501 YBL034C STU1
SGTC_3161 9100388 49.47 µM -0.491439718325559 0.300018047894181 no 2350 0.311557739075107 3295 25236368
SGTC_394 menadione 8.33 µM -0.492324287624787 0.29969892148016 no 2351 0.311245056559489 3348 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_367 0335-0881 7.1 µM -0.493356448328291 0.299326742967633 no 2352 0.31088037473 3387 23828853
SGTC_211 3455-0679 143.504 µM -0.494640897921078 0.298863886636235 no 2353 0.310426813787362 3366 748649
SGTC_333 3486-0131 40.1 µM -0.495547622061861 0.298537341053543 no 2354 0.310106807534121 3409 6744690
SGTC_1945 st075991 56.6 µM -0.496375413425992 0.298239363943426 no 2355 0.30981478420928 3277 1084980
SGTC_1782 st039423 80.636 µM -0.497776984265055 0.297735154519771 no 2356 0.309320619962176 3263 2068169
SGTC_3295 9122362 53.5725 µM -0.498273760760606 0.297556534583442 no 2357 0.309145549761354 3348 4730473
SGTC_1080 nisoldipine 24.4 µM -0.498622795741106 0.297431065549603 no 2358 0.309022571418222 3223 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_403 arphamenine a 50 µM -0.502259818797803 0.296125090197959 no 2359 0.307742384869986 3326 5487158 An arginine aminopeptidase inhibitor.
SGTC_1831 st055328 12 µM -0.503202901752084 0.295786879844267 no 2360 0.307410812440455 3389 1103068
SGTC_387 norethindrone acetate 66.7 µM -0.504466074479996 0.29533415647572 no 2361 0.306966948225047 3320 541197
SGTC_1109 tnp00067 928.257 nM -0.504705277164635 0.295248461724674 no 2362 0.306882927007372 3330 676295
SGTC_1803 st050068 52.4 µM -0.504905142704795 0.295176868347651 no 2363 0.306812730949287 3428 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2100 5377183 190 µM -0.505180407845928 0.295078279339129 no 2364 0.306716064909942 3335 2844202
SGTC_912 3474-0017 2.18 µM -0.50734204140794 0.294304596030445 no 2365 0.305957422448001 3419 3360550
SGTC_1019 4262-0212 3.4 µM -0.507950609255931 0.294086948966413 no 2366 0.305743990621868 3386 4677213
SGTC_2831 7999036 19.48 µM -0.509686155301057 0.293466660500933 no 2367 0.305135676943684 3426 2988270
SGTC_949 1165-0505 146 µM -0.511115736100358 0.292956180403017 no 2368 0.304635008859919 3280 6244267
SGTC_2220 6782180 200 µM -0.513883466744647 0.291969041612087 no 2369 0.303666733691154 3337 833803
SGTC_94 0334-0113 514.748 µM -0.514145359180462 0.291875715324912 no 2370 0.303575183265048 3341 6795178
SGTC_1427 4048-4900 550 nM -0.51466938242303 0.291689019535005 no 2371 0.30339203609708 3399 24132586
SGTC_3181 9108277 49.47 µM -0.516013019532631 0.29121057124404 no 2372 0.302922658004261 3288 17097298
SGTC_1102 cgs 12066b 26.1 µM -0.516588591788209 0.291005731061513 no 2373 0.302721690551439 3349 6438352 A 5-HT1B full agonist.
SGTC_1688 st021091 57.6 µM -0.517651971853456 0.29062746232717 no 2374 0.302350556770179 3408 3656366
SGTC_399 oxolinic acid 75 µM -0.517922085361771 0.290531413390976 no 2375 0.302256316081 3302 4628 A DNA gyrase inhibitor.
SGTC_1853 st056710 91.2 µM -0.518001935977983 0.290503022370057 no 2376 0.302228459291186 3449 269167
SGTC_64 000l-0018 272.079 µM -0.521481558245206 0.289267099877995 no 2377 0.301015674615028 3354 6811119
SGTC_3084 9116877 49.47 µM -0.521545641440621 0.28924436144617 no 2378 0.300993359697176 3349 27241325
SGTC_3237 9133362 49.47 µM -0.521806728589107 0.289151729427893 no 2379 0.300902452179765 3385 43845137
SGTC_3316 9136639 10.545 µM -0.52239066839465 0.288944601893591 no 2380 0.300699175941064 3402 4903665
SGTC_2267 7931562 200 µM -0.52257255976084 0.288880098016357 no 2381 0.300635870102134 3236 934880
SGTC_783 0848-0141 92.7 µM -0.523662644683921 0.288493664830636 no 2382 0.30025660088012 3374 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3108 9121785 49.47 µM -0.523684344242423 0.288485974848902 no 2383 0.300249053228908 3388 17140271
SGTC_2869 9037858 32.47 µM -0.523759925311669 0.288459190862707 no 2384 0.300222764905218 3360 27187042
SGTC_1800 st050079 29.0735 µM -0.523936239863053 0.288396714078842 no 2385 0.30016144388554 3370 3645560
SGTC_82 0054-0107 293.755 µM -0.524110932348653 0.288334818363433 no 2386 0.300100692595967 3366 3104697
SGTC_1194 1488-0194 225 µM -0.524589029303866 0.288165454715707 no 2387 0.29993445741213 3305 1391452
SGTC_2885 9057732 51.95 µM -0.525387111319145 0.287882842443539 no 2388 0.299657055728054 3439 6471414
SGTC_1960 st011366 51.8 µM -0.526447761643297 0.287507453666596 no 2389 0.299288569119619 3392 3972846
SGTC_2932 9016711 44.54 µM -0.529443560259351 0.286448422971908 no 2390 0.298248893528988 3424 7117328
SGTC_396 dithiazanine 1.25 µM -0.532094217522304 0.28551294788943 no 2391 0.297330371064831 3330 10578 An antihelmenthic.
SGTC_1086 cerivastatin 2.18 µM -0.532601660925243 0.285334025979132 no 2392 0.297154676075177 3395 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.53320043162037 0.285122971255996 no 2393 0.296947421388883 3368 2724278 An inhibitor of dopamine biosynthesis.
SGTC_327 1273-0057 3.96 µM -0.533242499354609 0.285108146017137 no 2394 0.296932862817184 3368 3108138
SGTC_2800 7887935 81.82 µM -0.533874384630463 0.284885505318981 no 2395 0.296714222716635 3420 2961002
SGTC_1518 st038567 90.8 µM -0.536666004480256 0.283902889983017 no 2396 0.295749171241343 3421 77966
SGTC_3006 9075424 71.4286 µM -0.537702656975711 0.283538414716946 no 2397 0.295391172318068 3338 7465181
SGTC_1129 3453-1384 223 µM -0.537982455672889 0.283440079107083 no 2398 0.295294580449367 3475 1084452
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.538583725977201 0.283228817219089 no 2399 0.295087059622687 3376 4620898
SGTC_2911 7942208 15.64 µM -0.538832248318237 0.283141518661195 no 2400 0.295001304908342 3400 1243384
SGTC_843 0310-0051 143 µM -0.539388143304736 0.282946295923165 no 2401 0.294809530263238 3380 2065037
SGTC_1843 st055809 45.5 µM -0.540167398329281 0.28267274103099 no 2402 0.294540796867433 3417 16413835
SGTC_2572 astragaloside iv 100 µM -0.541004091429185 0.282379164263533 no 2403 0.294252381321266 3443 45006101 An anti-inflammatory agent.
SGTC_2160 5660466 132.927 µM -0.541305944418313 0.282273286860122 no 2404 0.294148361944662 3417 2859134
SGTC_2723 salbutamol 83.58 µM -0.54406798344678 0.281305367264266 no 2405 0.293197345707184 3405 9884233 β2-adrenoceptor agonist
SGTC_479 n-linoleoylglycine 10 µM -0.545591459240244 0.280772172048724 no 2406 0.292673398255787 3388 6433346 An anti-infammatory.
SGTC_2863 9028737 58.44 µM -0.545909682971882 0.280660859929563 no 2407 0.292564011008358 3364 6460917
SGTC_632 0781-2353 4.65 µM -0.545943401364488 0.280649066756148 no 2408 0.292552421653001 3439 6811515 YHR007C ERG11
SGTC_2872 9044037 25.97 µM -0.546465401319081 0.280466525298266 no 2409 0.29237303216803 3407 6465195
SGTC_2680 butyl paraben 22.24 µM -0.546592612190648 0.280422048837147 no 2410 0.292329322880699 3439 7184 An antifungal and steroid mimetic.
SGTC_2244 6635614 200 µM -0.547619355667285 0.280063195799119 no 2411 0.291976648091021 3203 836499
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.548047549780453 0.279913605171706 no 2412 0.291829626810214 3397 688669
SGTC_1156 4092-0367 4.88 µM -0.549694970417497 0.27933843645203 no 2413 0.291264303582982 3390 1357585
SGTC_3287 9117173 37.0625 µM -0.55088356581927 0.278923815613423 no 2414 0.290856746974004 3368 2789709
SGTC_1030 k029-0042 36.7 µM -0.551014367749925 0.278878205927862 no 2415 0.290811912682429 3400 6080581
SGTC_481 bay k-8644 50 µM -0.551286437957265 0.278783348643559 no 2416 0.29071866695588 3384 2303 A calcium channel antagonist.
SGTC_1434 4073-0095 163 µM -0.554397491816979 0.277699797511328 no 2417 0.289653421126602 3462 24133745
SGTC_966 1300-0360 30.2 µM -0.554903415653044 0.27752378359 no 2418 0.289480362739918 3374 70588
SGTC_2878 9043973 25.97 µM -0.555669383963104 0.277257402446609 no 2419 0.28921844492915 3489 6465167
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.555696281092218 0.277248050693276 no 2420 0.289209249658261 3397 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2764 methyldopa 94.69 µM -0.559109458972176 0.276062590434415 no 2421 0.288043509820454 3515 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1352 1496-0991 99 µM -0.559395555070994 0.275963337090454 no 2422 0.287945897126557 3402 3000039
SGTC_2266 7929956 200 µM -0.559627603652217 0.275882846953347 no 2423 0.287866736295977 3465 2967153
SGTC_931 2812-0076 566 µM -0.560807468061212 0.275473768699421 no 2424 0.287464397549594 3379 3450959
SGTC_3302 9125395 16.351 µM -0.561538300062717 0.275220527054813 no 2425 0.28721531420396 3359 17599668
SGTC_1064 honokiol 6.76 µM -0.562892983056588 0.274751417238823 no 2426 0.286753879317095 3427 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2625 euphol 100 µM -0.563485053926959 0.274546514359302 no 2427 0.286552317350077 3481 6708538 A triterpene alcohol.
SGTC_3310 9130229 44.1445 µM -0.56447535909293 0.274203959828939 no 2428 0.286215332576743 3460 7761258
SGTC_2272 7805186 180 µM -0.564975197688001 0.274031141832224 no 2429 0.286045317116397 3465 2956062 YPR165W RHO1
SGTC_2439 5492030 7.2 µM -0.56533224105699 0.27390772790698 no 2430 0.285923901518231 3431 5722370
SGTC_999 SEC7.066 22.7 µM -0.565739340400354 0.273767045403312 no 2431 0.285785493865031 3433 740511 YDR170C SEC7
SGTC_2385 9074692 200 µM -0.565750290225484 0.273763261933989 no 2432 0.285781771529303 3418 17046906
SGTC_2095 5432005 200 µM -0.566539732663242 0.273490555763016 no 2433 0.285513465485503 3399 783734
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.566943999616579 0.273350957265505 no 2434 0.285376114618335 3493 364106
SGTC_2092 5303694 80.6725 µM -0.567558767937863 0.273138737635133 no 2435 0.285167305636112 3410 1963699
SGTC_2732 terfenadine 20 µM -0.568482710810309 0.272819943783191 no 2436 0.28485362107269 3446 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1820 st053765 18.6 µM -0.568508768715537 0.272810955536172 no 2437 0.284844776633252 3454 3690829
SGTC_1121 fusaric acid 630.51 nM -0.569549214519082 0.272452190895011 no 2438 0.284491740999543 3371 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_181 1447-1644 8.07 µM -0.569962858492042 0.272309624048507 no 2439 0.284351444768028 3450 534600
SGTC_52 0329-0193 875 nM -0.570259635950878 0.27220735934506 no 2440 0.284250806698753 3548 3739292
SGTC_640 3381-0960 37.1 µM -0.571978000659016 0.271615614181616 no 2441 0.283668439369792 3487 1745025
SGTC_3178 9107506 49.47 µM -0.573034461876075 0.271252123824752 no 2442 0.283310680264163 3498 8897194
SGTC_1587 estradiol valerate 56.1 µM -0.573488867935056 0.271095853634025 no 2443 0.283156867169525 3508 13791 A steroid.
SGTC_1602 st001878 87.6 µM -0.573567728486935 0.271068738072296 no 2444 0.283130177535831 3510 595405 YLR310C CDC25
SGTC_1753 st043925 64 µM -0.573845960527051 0.270973081046747 no 2445 0.283036022086269 3460 670181
SGTC_1198 1612-1005 86.7 µM -0.5756717119356 0.270345800283579 no 2446 0.282418549652482 3560 6998509
SGTC_2988 9073640 71.4286 µM -0.57568307773369 0.270341897565194 no 2447 0.28241470774911 3540 9102229
SGTC_2499 avocadenofuran 51.48 µM -0.576213452552853 0.27015981202311 no 2448 0.282235456720215 3353 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3062 9077494 49.47 µM -0.577761490599705 0.269628698653338 no 2449 0.281712578932675 3455 16459633
SGTC_1221 2958-7315 257 µM -0.581729264751934 0.268269795687518 no 2450 0.280374528102897 3491 4562705
SGTC_3266 9136860 49.47 µM -0.582625676111225 0.267963266105738 no 2451 0.280072658376401 3444 4871271 YPR165W RHO1
SGTC_804 1595-0054 20.9 µM -0.584525036990107 0.267314359294298 no 2452 0.279433562810679 3409 761523 Stimulates phospholipase C.
SGTC_2218 6965428 192.983 µM -0.585644317648565 0.266932334474643 no 2453 0.279057280050935 3486 675684
SGTC_1276 0871-0068 94.2 µM -0.587248644405338 0.266385238577033 no 2454 0.278518363282629 3442 3414906
SGTC_1288 0973-0013 65.5 µM -0.587511260719335 0.266295737129522 no 2455 0.278430194942298 3507 4315430
SGTC_1978 st071761 42 µM -0.587616529719724 0.266259865003064 no 2456 0.278394856733402 3419 5147680
SGTC_2729 fluphenazine 10.66 µM -0.587619482498033 0.266258858831029 no 2457 0.278393865533916 3424 3372 An atypical antipsychotic.
SGTC_254 nsc-64875 3.808 µM -0.58787462256319 0.266171926013813 no 2458 0.278308225673346 3518 56993
SGTC_1171 0368-0077 21.4 µM -0.588056912589627 0.266109823891084 no 2459 0.278247046393686 3460 3239779
SGTC_2174 5790901 200 µM -0.590099137083953 0.265414585749604 no 2460 0.277562093666287 3487 786020
SGTC_370 0180-0345 38.7 µM -0.590313229768685 0.265341755208613 no 2461 0.277490335703825 3432 3989527
SGTC_2528 xanthyletin 44.79 µM -0.590345298869222 0.26533084674195 no 2462 0.277479587806766 3463 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_543 3844-1095 191 µM -0.590494806538983 0.26527999395682 no 2463 0.277429483285887 3479 4230703
SGTC_2664 lyso-paf C-16 73.48 µM -0.590503007438454 0.265277204687366 no 2464 0.277426735045556 3476 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_692 k241-0027 77.8 µM -0.591832125791157 0.264825345103107 no 2465 0.276981504164388 3567 3600480
SGTC_3353 9151644 39.2805 µM -0.594538126212363 0.263906598511647 no 2466 0.27607612489638 3509 4909158
SGTC_754 3474-0146 171 µM -0.594693763432942 0.263853805711301 no 2467 0.276024095691399 3373 24762078
SGTC_3192 9110362 49.47 µM -0.596211988355879 0.263339100023678 no 2468 0.275516808924611 3577 16649480
SGTC_1507 4075-3230 155 µM -0.598506003926758 0.262562361048216 no 2469 0.274751177009286 3461 659771
SGTC_909 3448-9333 149 µM -0.598629278368914 0.262520654334662 no 2470 0.274710063656141 3477 3344074
SGTC_1798 st045719 60.953 µM -0.600622710205011 0.261846699426603 no 2471 0.274045654162023 3477 3980186
SGTC_2576 guaiol 23.12 µM -0.600967001010675 0.2617303888518 no 2472 0.27393098273301 3490 227829
SGTC_2906 7926292 26.41 µM -0.601716851416932 0.261477161242508 no 2473 0.273681315459854 3524 2966319
SGTC_347 4534-1311 26.2 µM -0.60196365852783 0.261393840976677 no 2474 0.27359916415543 3523 2862016
SGTC_823 0417-1665 178 µM -0.602322673018109 0.261272664672774 no 2475 0.273479685705726 3510 3429856
SGTC_36 0335-0881 14.2 µM -0.602844718793069 0.261096512771244 no 2476 0.273305997255253 3476 23828853
SGTC_312 4092-0653 6.84 µM -0.604432988426926 0.260560964693237 no 2477 0.272777904527407 3509 1148278
SGTC_249 wiskostatin 11.211 µM -0.605182003889519 0.260308600817107 no 2478 0.272529035932496 3533 2775510 A n-wasp and actin depolymerizer.
SGTC_392 N-ethylmaleimide 8.33 µM -0.60702859159826 0.25968697309077 no 2479 0.271915968892279 3462 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2170 morpholine 200 µM -0.608178370039482 0.259300303819406 no 2480 0.271534589377898 3526 121171 Reacts with secondary amines.
SGTC_991 3996-0057 64.7 µM -0.609483741360148 0.258861669728917 no 2481 0.271101923142808 3512 715343
SGTC_277 nystatin 15.5 µM -0.609624379605145 0.258814435038372 no 2482 0.271055329023172 3481 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2030 5175110 200 µM -0.610651796789732 0.258469502571694 no 2483 0.270715062044783 3583 2831986
SGTC_220 paclitaxel 373.376 µM -0.610748391394177 0.258437085332401 no 2484 0.270683082161774 3517 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1999 st074831 12.5 µM -0.611830011073342 0.258074236649029 no 2485 0.270325115774353 3457 17112523
SGTC_1159 4092-0538 61.2 µM -0.612826604442168 0.257740145570495 no 2486 0.269995498800609 3569 717301
SGTC_1258 0671-0043 57.1 µM -0.613703222711673 0.257446459816144 no 2487 0.269705729193555 3502 4298767
SGTC_2865 9030313 51.95 µM -0.614704431850692 0.257111246275512 no 2488 0.269374966242902 3478 42562754
SGTC_2644 guaiazulene 100 µM -0.614992160992252 0.25701495405773 no 2489 0.269279948674243 3528 3515 A coloring agent.
SGTC_257 daunorubicin 18.5 µM -0.616129064067452 0.256634658562637 no 2490 0.268904670614621 3544 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2552 juarezic acid 87.02 µM -0.61723130963131 0.256266236011174 no 2491 0.268541083468998 3601 1549512
SGTC_1433 4060-0023 7.6 µM -0.617593971640899 0.256145077541392 no 2492 0.268421509690225 3550 3840627
SGTC_2319 6033012 152.6 µM -0.619585677705723 0.255480219365392 no 2493 0.267765299238141 3465 847246
SGTC_832 4083-0019 164 µM -0.620209605722154 0.255272129455447 no 2494 0.267559899110866 3618 1990758
SGTC_2013 4024628 200 µM -0.62054328229498 0.255160879391187 no 2495 0.267450083776476 3578 5230760
SGTC_2384 9036245 200 µM -0.621069194041468 0.254985588285156 no 2496 0.267277048638535 3490 6462766
SGTC_1967 st070177 51.4 µM -0.622709533282746 0.254439253497011 no 2497 0.266737708427235 3590 5729214
SGTC_870 0573-2213 57.6 µM -0.624221942866912 0.253936071289923 no 2498 0.26624091909655 3563 3916321
SGTC_749 1000-0129 128 µM -0.627814920612124 0.252742776365438 no 2499 0.265062595302064 3609 708470
SGTC_2325 6158266 200 µM -0.628564973120999 0.25249404299662 no 2500 0.264816948838114 3527 3623240
SGTC_1101 ebselen 5.29 µM -0.629327458608077 0.252241318861267 no 2501 0.264567349182713 3617 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1358 1509-0022 2.48 µM -0.630742465987365 0.251772671466602 no 2502 0.264104463825538 3567 3258434
SGTC_2563 tomatine 8.54 µM -0.630956706404301 0.251701755596926 no 2503 0.264034416247774 3591 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3167 9103034 49.47 µM -0.632107086259933 0.251321148025946 no 2504 0.263658452530672 3561 5127859
SGTC_2534 helenine 20.12 µM -0.632562539610974 0.251170543667072 no 2505 0.263509678125017 3574 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1778 st046819 58.9 µM -0.63333612317734 0.25091485289927 no 2506 0.263257084309921 3567 671715
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.635286620295466 0.2502707717402 no 2507 0.262620749111948 3553 15053
SGTC_1526 st051518 75 µM -0.636071293863192 0.250011909150547 no 2508 0.262364977379322 3479 673993
SGTC_704 1310-0270 142 µM -0.636108376162254 0.249999679274407 no 2509 0.262352893212494 3562 5718033
SGTC_2874 9043904 71.43 µM -0.636566621309807 0.249848574573821 no 2510 0.262203586441812 3491 4463428
SGTC_2602 kawain 100 µM -0.636772940350914 0.249780557438996 no 2511 0.262136377185903 3568 5369129
SGTC_1627 st003713 25.6 µM -0.640047161407047 0.248702463308508 no 2512 0.261070969530474 3595 16195070 YER133W GLC7
SGTC_496 calpeptin 138 µM -0.640088863368524 0.248688748213676 no 2513 0.261057414386531 3545 73364 A calpain inhibitor.
SGTC_1302 1159-0335 255 µM -0.641048416377264 0.248373278180034 no 2514 0.260745613464697 3581 649284
SGTC_201 4262-0159 12.803 µM -0.641576365456809 0.248199796589551 no 2515 0.260574141375632 3531 1341029
SGTC_2041 5107442 45.335 µM -0.642886260417056 0.247769650461542 no 2516 0.26014895265237 3610 793005
SGTC_1672 st016598 6.51 µM -0.643275783494382 0.247641814856102 no 2517 0.260022583427892 3526 4665860 YNL267W PIK1
SGTC_1187 1391-0724 117 µM -0.643936985615043 0.247424898959114 no 2518 0.259808148475476 3600 6997986
SGTC_1316 1272-0050 65.9 µM -0.644015767488869 0.247399060319605 no 2519 0.259782604752186 3601 7340392
SGTC_1706 st031321 9.9705 µM -0.644510886994646 0.247236705547314 no 2520 0.259622100087976 3592 6103185
SGTC_223 busulfan 5 mM -0.645874820163655 0.24678975264344 no 2521 0.259180213901053 3570 2478 A DNA alkylator.
SGTC_2551 apiole 73.87 µM -0.645896115376281 0.246782777758385 no 2522 0.259173317775526 3484 10659 A possible DNA adduct former.
SGTC_3156 9099931 49.47 µM -0.646250741668231 0.246666641456182 no 2523 0.259058491474289 3587 18111053
SGTC_2048 5246248 200 µM -0.647356456555427 0.246304719691614 no 2524 0.258700635230979 3591 677046
SGTC_1500 4488-1866 171 µM -0.64893245751245 0.245789356681531 no 2525 0.258191017108468 3658 2900003
SGTC_102 gallobenzophenone 83.616 µM -0.649586511424426 0.245575646709584 no 2526 0.257979674130949 3639 70837
SGTC_2804 7954240 19.48 µM -0.650205679020256 0.245373427731093 no 2527 0.257779686608097 3599 828705
SGTC_2589 lobaric acid 100 µM -0.650680205982217 0.24521850871014 no 2528 0.257626471650202 3567 73157 A novel microtubule depolymerizer.
SGTC_1225 1216-0074 20.6 µM -0.651778641296549 0.244860103916028 no 2529 0.257271991070809 3580 4241466
SGTC_2653 dihydrofissinolide 100 µM -0.6520405669456 0.244774682717142 no 2530 0.257187501417534 3611 6857746
SGTC_1771 st048882 4.1505 µM -0.652539561683193 0.24461199113315 no 2531 0.257026580049782 3542 4580403
SGTC_2942 9052777 62.25 µM -0.652930318539459 0.244484629954588 no 2532 0.256900601011824 3676 6469503
SGTC_1763 st044482 94.5 µM -0.652933509553075 0.244483590039934 no 2533 0.256899572369255 3585 88505
SGTC_2086 5274770 176.623 µM -0.653426960038451 0.244322808879828 no 2534 0.256740531410438 3584 689278
SGTC_1133 3473-0247 50 µM -0.653974755208885 0.244144387341231 no 2535 0.256564035007802 3560 711311
SGTC_133 0724-0033 378.92 µM -0.655664454222525 0.243594480913976 no 2536 0.256020022230047 3513 280309
SGTC_2026 5148700 152 µM -0.655730088284009 0.243573134050549 no 2537 0.255998902940865 3594 79838
SGTC_2120 5538279 151.968 µM -0.659209452900951 0.242442951030228 no 2538 0.2548806387801 3620 2058197
SGTC_1755 st041960 45.185 µM -0.662358047409664 0.241422663862573 no 2539 0.253870891766989 3623 2257073
SGTC_855 0428-0020 25 µM -0.663700676062692 0.240988301793042 no 2540 0.253440953294951 3599 6812414
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.664862351046821 0.240612824375846 no 2541 0.253069269059198 3601 521171
SGTC_1439 4092-1168 46 µM -0.664976073333573 0.240576084099763 no 2542 0.253032898410958 3612 2886240
SGTC_869 0564-0080 44.1 µM -0.665095959543919 0.240537355751363 no 2543 0.252994559395399 3589 6843321
SGTC_2557 derrustone 83.84 µM -0.665269847077748 0.240481188710415 no 2544 0.252938956456843 3621 629853 An antioxidant.
SGTC_1597 7-benzyloxygramine 47.5 µM -0.666925792076311 0.239946663498337 no 2545 0.252409767602029 3602 260807
SGTC_1814 st052110 31.539 µM -0.667677672734214 0.239704176760674 no 2546 0.252169682545094 3616 674163
SGTC_544 k015-0020 52.4 µM -0.668418543406981 0.239465371684225 no 2547 0.251933230978116 3621 3008304
SGTC_691 1548-0686 185 µM -0.668925490486667 0.239302042161894 no 2548 0.251771504428032 3601 46495133
SGTC_1318 1280-3875 124 µM -0.669022678730328 0.239270736755338 no 2549 0.251740505641555 3611 373245
SGTC_2931 9014674 55.67 µM -0.670077673440974 0.2389310553186 no 2550 0.251404138329215 3629 2996810
SGTC_3138 9097216 49.47 µM -0.670256768900732 0.238873417333779 no 2551 0.251347060350969 3636 25237486
SGTC_794 k038-0031 316 µM -0.67166765149612 0.238419621430707 no 2552 0.250897649718307 3665 6624242
SGTC_682 0kpi-0099 17 µM -0.671957909651269 0.238326321456314 no 2553 0.250805246114884 3643 1714895 YML126C ERG13
SGTC_520 3584-0023 682 µM -0.672284996280187 0.238221207382677 no 2554 0.250701139772814 3597 1340790
SGTC_1363 1636-0063 10.4 µM -0.673685182045165 0.237771524414488 no 2555 0.250255742267833 3665 6072185
SGTC_2437 5741531 144.16 µM -0.673755093062627 0.237749084037226 no 2556 0.250233514655626 3689 2262990
SGTC_2989 9073649 71.4286 µM -0.674604062368868 0.23747667048717 no 2557 0.249963675669959 3629 21367202
SGTC_654 1124-0271 80.9 µM -0.674686614274745 0.237450190736805 no 2558 0.249937445361384 3641 5403748
SGTC_1442 4112-3290 3 µM -0.678404715664089 0.236259236540349 no 2559 0.248757559985325 3630 704353
SGTC_213 1246-0773 967 nM -0.679064896667146 0.23604811675823 no 2560 0.248548371637286 3609 6251622
SGTC_1185 1319-0113 81.3 µM -0.68032318092244 0.235646017104949 no 2561 0.248149924909299 3661 4672763
SGTC_2152 5568786 200 µM -0.680827155329652 0.235485072133394 no 2562 0.247990432605532 3621 5399883
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.681055919049723 0.235412036121647 no 2563 0.247918054021288 3613 17037758
SGTC_1640 st009078 66.4 µM -0.682727995313587 0.234878582246032 no 2564 0.247389368123878 3651 690618
SGTC_2994 9053520 71.4286 µM -0.683135821989905 0.234748571944343 no 2565 0.247260510804826 3633 4647384
SGTC_1041 0206-0046 107 µM -0.683286151509087 0.234700658716205 no 2566 0.247213021595208 3643 50494
SGTC_1989 st071868 50.2 µM -0.68348404362438 0.234637594517839 no 2567 0.247150514762126 3641 16414057
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.683761083748614 0.234549323201127 no 2568 0.247063022189208 3667 5282362
SGTC_1676 st018489 23.4 µM -0.68484222482939 0.234205022712378 no 2569 0.246721743510719 3669 3696235
SGTC_2492 derrusnin 100 µM -0.686151635929062 0.233788402221958 no 2570 0.246308746158837 3594 1715307 Part of coumarin class of compounds.
SGTC_2198 6589944 200 µM -0.686935649587799 0.233539146235958 no 2571 0.246061640303582 3618 5290268
SGTC_2280 7785178 200 µM -0.687577651431639 0.233335148877927 no 2572 0.245859392887174 3653 2954328
SGTC_3032 9089427 49.47 µM -0.688506109012395 0.23304030461598 no 2573 0.245567062294838 3629 17173707
SGTC_1929 genistein trimethyl ether 50.5 µM -0.690251398096551 0.232486624856467 no 2574 0.24501805301065 3674 136420
SGTC_591 4299-0174 154 µM -0.691719566677501 0.232021426571009 no 2575 0.244556728376293 3646 5509088
SGTC_2801 7907800 81.82 µM -0.69219532160434 0.231870791938103 no 2576 0.244407338161822 3702 6620925
SGTC_1768 st044301 37.178 µM -0.692528350192584 0.231765380069006 no 2577 0.244302794233964 3677 3931349
SGTC_1167 k781-0610 148 µM -0.692647688070201 0.231727613147772 no 2578 0.244265337700166 3695 4525169
SGTC_887 0885-0007 9.62 µM -0.692749462109073 0.231695407373213 no 2579 0.244233396367713 3691 5719458
SGTC_296 1222-0039 74.9 µM -0.692916843099996 0.231642446102878 no 2580 0.244180869480584 3618 5984176
SGTC_1737 st035557 69.7 µM -0.694640187142414 0.231097552730282 no 2581 0.243640410370838 3575 5716916
SGTC_2204 7233102 200 µM -0.696760115911714 0.230428248002377 no 2582 0.242976465056958 3598 2172480
SGTC_625 k213-0058 121 µM -0.697950190009861 0.230052992782727 no 2583 0.242604172427517 3738 3655420
SGTC_831 k061-1017 217 µM -0.69902096268034 0.229715648252007 no 2584 0.242269465207048 3722 1240153
SGTC_574 1315-0397 40 µM -0.69935591730538 0.229610178462008 no 2585 0.242164814908459 3703 6794277
SGTC_2113 5491891 107.031 µM -0.700640290947716 0.22920600919894 no 2586 0.241763763668546 3684 789979
SGTC_1925 st057770 10.1 µM -0.703221106170182 0.228395080621315 no 2587 0.240958983965686 3651 5989122
SGTC_3020 9089140 49.47 µM -0.703764080125643 0.228224676044954 no 2588 0.240789853246726 3689 17217859
SGTC_114 0364-0001 490.298 µM -0.703921953593941 0.228175143139755 no 2589 0.240740689433531 3693 4003655
SGTC_2957 9076800 11.52 µM -0.704562527263259 0.227974224756007 no 2590 0.240541262678792 3644 16459615
SGTC_1321 1326-2144 215 µM -0.704864592216127 0.227879515467279 no 2591 0.240447253452057 3678 3513030
SGTC_2357 9067248 200 µM -0.706241475970693 0.227448088605471 no 2592 0.24001899067983 3685 9150235
SGTC_2623 humulene 100 µM -0.706263083234967 0.227441321946348 no 2593 0.24001227332203 3632 6187145 An anti-inflammatory.
SGTC_1780 st038448 24.544 µM -0.706691264661454 0.22730725349981 no 2594 0.239879179612409 3728 728868 YDL195W SEC31
SGTC_3100 9120536 49.47 µM -0.707018760454247 0.227204740925263 no 2595 0.239777409683289 3570 16421196
SGTC_2197 6588183 93.1375 µM -0.707495417377222 0.227055584577675 no 2596 0.239629329758521 3652 884136
SGTC_2850 9015429 58.44 µM -0.70758693824844 0.227026952020095 no 2597 0.239600903274275 3709 6457570
SGTC_3145 9085516 49.47 µM -0.708632972771789 0.22669984187744 no 2598 0.239276134573605 3706 25236195
SGTC_2085 5307070 144.047 µM -0.709124298242404 0.226546289139852 no 2599 0.2391236728178 3659 2840351
SGTC_868 0527-0199 213 µM -0.709621123940096 0.2263910771538 no 2600 0.23896955830807 3659 2849450
SGTC_1563 conessine 56.1 µM -0.709624581813056 0.226389997099457 no 2601 0.238968485871939 3762 441082 An anti-amoebic, histamine inhibitor.
SGTC_2058 5236698 133 µM -0.711382447213601 0.225841310985163 no 2602 0.238423636544886 3709 766665
SGTC_657 3534-0529 86.7 µM -0.712832308749092 0.225389329255248 no 2603 0.237974765203077 3714 1049549
SGTC_2624 nerol 100 µM -0.713253900512158 0.225257997864309 no 2604 0.237844329072206 3642 637566 A natural product oil.
SGTC_349 k015-0014 24 µM -0.714842965715795 0.224763372847533 no 2605 0.237353041308512 3693 2196908
SGTC_1029 k015-0030 64.7 µM -0.715884101318634 0.224439634970409 no 2606 0.237031458115815 3761 2208316
SGTC_37 0566-0070 1.56 µM -0.716038460330425 0.224391660051517 no 2607 0.236983800505833 3717 1626686
SGTC_1502 4534-4282 27.7 µM -0.716554145178699 0.224231426950323 no 2608 0.236824623459058 3684 3278949
SGTC_2630 antimycin a 100 µM -0.71700452443532 0.224091538703529 no 2609 0.236685652473328 3720 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_924 2046-0044 21.3 µM -0.717628134819394 0.223897926556692 no 2610 0.236493302615625 3705 3623589
SGTC_2847 9005661 71.43 µM -0.71770856472363 0.223872962428847 no 2611 0.236468500633192 3636 2991449
SGTC_1715 st032160 10.2275 µM -0.722192135349223 0.222483839550083 no 2612 0.235088178980447 3626 5289825
SGTC_2061 5245884 80.95 µM -0.7226015487475 0.222357238369946 no 2613 0.234962358231825 3696 573863
SGTC_1631 benzylvanillin 81.9 µM -0.723014896236052 0.222229462367232 no 2614 0.234835366216124 3737 75506
SGTC_1011 4112-3381 17.4 µM -0.724326488459844 0.221824294064012 no 2615 0.234432659351854 3757 2877139
SGTC_641 4092-0595 30 µM -0.725898323190453 0.221339289673935 no 2616 0.233950552269614 3743 786260
SGTC_1013 4112-3890 241 µM -0.726278186517838 0.221222170323189 no 2617 0.233834124519458 3687 705171
SGTC_2465 5809242 33.21 µM -0.727877672078867 0.220729406477104 no 2618 0.233344236128756 3713 2731748
SGTC_3207 9114163 49.47 µM -0.729472289372967 0.220238768789087 no 2619 0.232856406194977 3739 849233
SGTC_579 4491-1009 110 µM -0.730089323676867 0.220049085352192 no 2620 0.232667793426957 3853 1271041
SGTC_2306 7482397 179.52 µM -0.730188294921891 0.220018669178202 no 2621 0.232637548166902 3716 891448
SGTC_281 1672-3440 14.9 µM -0.730960835667982 0.219781332284146 no 2622 0.232401537592549 3754 6833000
SGTC_3317 9138495 8.753 µM -0.732919850742216 0.219180150777296 no 2623 0.23180365752833 3708 17020139
SGTC_617 3770-0098 35 µM -0.733484075455258 0.21900717730936 no 2624 0.231631618475765 3685 5962639
SGTC_2119 5528445 120.635 µM -0.734261335226827 0.218769022643308 no 2625 0.231394738992541 3740 791935
SGTC_427 1354-0053 47.3 µM -0.735054842442955 0.218526043521353 no 2626 0.23115304731963 3802 6813657
SGTC_1020 4335-0961 93.3 µM -0.736556693763062 0.218066588625196 no 2627 0.230695989364656 3690 669075
SGTC_1435 4092-0789 56.7 µM -0.736858185293179 0.217974421780987 no 2628 0.230604297426257 3738 2248285
SGTC_3340 9146634 11.102 µM -0.737342945776648 0.217826276180004 no 2629 0.230456911018689 3754 4907387
SGTC_2359 9039622 200 µM -0.737534769904434 0.217767669660417 no 2630 0.230398603422325 3689 6463596
SGTC_1215 3852-0577 11.2 µM -0.738827610434268 0.2173729155575 no 2631 0.230005841851383 3812 2884876
SGTC_1987 st072290 61.9 µM -0.73956367845446 0.217148350299153 no 2632 0.229782393814608 3742 54697379
SGTC_573 3702-0553 84.7 µM -0.739859444841438 0.217058153390287 no 2633 0.229692642311274 3700 1222756
SGTC_273 hydroxyurea 18.1 mM -0.740263278366539 0.216935035296306 no 2634 0.229570129111099 3790 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1448 4255-0083 152 µM -0.741495926635178 0.216559483386964 no 2635 0.229196400332541 3775 5399660
SGTC_1725 st036284 20.55 µM -0.742018909752956 0.216400259428557 no 2636 0.2290379393158 3771 707914
SGTC_1325 1431-0015 227 µM -0.744101318084173 0.215766935642593 no 2637 0.22840759098421 3699 1103340
SGTC_2730 imipramine 71.33 µM -0.744410995110391 0.215672845279515 no 2638 0.228313934585236 3750 3696 A tricyclic antidepressant.
SGTC_1172 0370-0043 85 µM -0.744621280489486 0.215608967026598 no 2639 0.228250349757613 3774 376585
SGTC_681 1642-0006 26.6 µM -0.744835495336669 0.215543906403234 no 2640 0.228185586997389 3756 4446530
SGTC_1913 st060213 96.1 µM -0.745136209556822 0.215452593689971 no 2641 0.228094690643969 3758 688959
SGTC_2601 securinine 100 µM -0.74594420176561 0.215207355774243 no 2642 0.227850561156355 3718 442872 A GABA receptor antagonist.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.746601124317545 0.215008089260939 no 2643 0.227652184774403 3749 689007
SGTC_1498 4478-3555 97.6 µM -0.746603931736971 0.215007237907004 no 2644 0.227651337203255 3720 3437919
SGTC_180 1486-1293 102.781 µM -0.748820280175182 0.214335738107602 no 2645 0.22698276730373 3732 4140536
SGTC_2314 7727897 200 µM -0.751810124684159 0.213431823149926 no 2646 0.226082626217186 3766 900724
SGTC_1656 st012921 11 µM -0.752246801735242 0.213299989481158 no 2647 0.22595132658671 3700 6732821
SGTC_1479 0549-0158 134 µM -0.75241174686519 0.213250204575839 no 2648 0.225901742265921 3800 5440202
SGTC_1380 2291-0730 164 µM -0.752865412344539 0.213113311005447 no 2649 0.22576539716968 3789 2999191
SGTC_2168 5727979 200 µM -0.755301979022493 0.212378954436588 no 2650 0.225033905759066 3701 695210
SGTC_2132 5317594 122.667 µM -0.756574412062799 0.211996044429059 no 2651 0.224652438018916 3739 794577
SGTC_2332 7982454 138.89 µM -0.756880646125805 0.211903950515242 no 2652 0.224560685686336 3736 2981748
SGTC_362 0310-0100 9.03 µM -0.758475014413322 0.21142485364658 no 2653 0.224083332593679 3837 790235
SGTC_1983 st071813 46.9 µM -0.759564663330204 0.211097786770308 no 2654 0.223757424077535 3827 11838595
SGTC_174 3553-0389 74.3 µM -0.759564820988492 0.211097739469372 no 2655 0.223757376942238 3752 738071
SGTC_23 0213-0011 39.996 µM -0.760790881451713 0.210730082404645 no 2656 0.223390990844083 3794 627608
SGTC_595 3909-8003 73.7 µM -0.761100358192672 0.210637339446204 no 2657 0.223298563276383 3848 699517
SGTC_1378 2093-0007 380 nM -0.76371180969112 0.209855702520031 no 2658 0.222519500752167 3831 3618014
SGTC_1880 MG-132 525 µM -0.76589571053036 0.209203347337327 no 2659 0.22186917920981 3712 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.766437747860869 0.209041619944122 no 2660 0.221707939746807 3826 279621
SGTC_618 k072-0232 33.2 µM -0.766553419140154 0.20900711670072 no 2661 0.221673539762925 3797 5872756 YGL099W LSG1
SGTC_703 3875-0075 71.8 µM -0.767326528120482 0.208776594452028 no 2662 0.221443699854275 3815 2850814
SGTC_3276 9139060 49.47 µM -0.768829777836255 0.208328791171885 no 2663 0.220997184438966 3855 4870619
SGTC_222 nsc-310342 10.666 µM -0.769014780567703 0.2082737198634 no 2664 0.220942268077892 3731 432556
SGTC_707 0865-0008 204 µM -0.769801123430493 0.208039738470604 no 2665 0.220708936606288 3781 723043
SGTC_562 3772-2733 112 µM -0.769876671784531 0.208017266743273 no 2666 0.22068652658126 3813 2876874 YIL048W NEO1
SGTC_3190 9110366 49.47 µM -0.772186163144706 0.207331004215109 no 2667 0.220002087774565 3724 17123768
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.773049536423515 0.207074798053335 no 2668 0.219746532323113 3811 23847180
SGTC_3226 9131256 49.47 µM -0.773053006322643 0.207073768738252 no 2669 0.219745505589147 3668 17178073
SGTC_1184 1269-1718 139 µM -0.773114570412166 0.20705550679542 no 2670 0.219727289395978 3835 5403821
SGTC_463 ikarugamyin 104 µM -0.774054671312427 0.206776760198932 no 2671 0.219449230741325 3825 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_351 caspofungin 25 nM -0.774646336487986 0.206601441237224 no 2672 0.219274334480552 3812 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1779 st039427 55 µM -0.775275150080768 0.206415211198253 no 2673 0.219088544993763 3795 1124498
SGTC_1482 3346-2049 8.48 µM -0.776839979424909 0.205952201792059 no 2674 0.21862659307854 3813 3826804
SGTC_2300 7976697 71.57 µM -0.779282063355875 0.205230858115752 no 2675 0.217906789104922 3726 2236109
SGTC_1578 josamycin 24.2 µM -0.779508894502831 0.205163932919666 no 2676 0.217840000084349 3802 5282165 A P450 substrate.
SGTC_646 4092-0839 27.3 µM -0.779568128961779 0.205146458276567 no 2677 0.217822560810675 3831 877796
SGTC_1353 1498-1206 8.11 µM -0.781760943733475 0.204500182857612 no 2678 0.217177539013168 3846 6756808
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.78200935154561 0.204427047564895 no 2679 0.217104538894033 3745 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2333 9017922 200 µM -0.783064187781789 0.204116660114184 no 2680 0.216794709947945 3842 3163164
SGTC_1134 3477-0009 42.5 µM -0.784510262920189 0.203691606416627 no 2681 0.216370381163317 3851 3973534
SGTC_2286 7945697 125 µM -0.78584179305237 0.203300688713656 no 2682 0.215980089319696 3834 1245733
SGTC_1892 st058411 7.36 µM -0.787811897071157 0.202723117063474 no 2683 0.21540337052804 3803 3934738
SGTC_407 eburnamonine 100 µM -0.789342511588776 0.202275067251771 no 2684 0.214955923120598 3699 3195
SGTC_3174 9107204 49.47 µM -0.789918150041911 0.202106716620666 no 2685 0.214787785433464 3839 3938802
SGTC_1790 st045711 43.5 µM -0.789986147814846 0.202086835600276 no 2686 0.214767929076189 3791 585119
SGTC_1450 4112-4260 37.6 µM -0.790407016231026 0.201963809175987 no 2687 0.214645052994808 3782 1633175
SGTC_1727 st034309 9.9045 µM -0.790519375937293 0.201930972259023 no 2688 0.214612255543038 3933 870305
SGTC_2786 7743617 45.45 µM -0.790754142942353 0.201862372350766 no 2689 0.214543737180353 3782 583674
SGTC_789 1309-1135 70.6 µM -0.792965086070438 0.201217010166858 no 2690 0.213899082351456 3811 3092424
SGTC_901 1112-0062 60.1 µM -0.793390375841414 0.201093012433832 no 2691 0.213775208123744 3817 1908457
SGTC_1257 0669-0121 16 µM -0.795607695729787 0.200447272041617 no 2692 0.213130046077084 3849 4307855
SGTC_764 1951-2361 146 µM -0.797438085268539 0.199915155263396 no 2693 0.212598323892183 3801 5438930
SGTC_1509 1326-1131 80 µM -0.798586281039434 0.199581794602174 no 2694 0.212265172566215 3743 768313
SGTC_2966 9084041 48.03 µM -0.798727388028301 0.199540849492668 no 2695 0.212224251152623 3781 17741380
SGTC_1087 pterostilbene 9.05 µM -0.801113894075279 0.19884912151702 no 2696 0.211532856678182 3888 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1496 4469-0713 57.4 µM -0.802465345137239 0.198458045732856 no 2697 0.211141913471706 3788 746691
SGTC_32 0928-0142 34.1 µM -0.80277011860552 0.1983699161586 no 2698 0.211053808177228 3784 2244242
SGTC_3054 9094397 49.47 µM -0.806785034850791 0.19721115219141 no 2699 0.209895171259943 3862 2598354
SGTC_2763 lisinopril 49.32 µM -0.806888394610624 0.197181375213828 no 2700 0.209865392825922 3759 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_433 pimozide 108 µM -0.807846178988087 0.196905575933808 no 2701 0.209589568775899 3765 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2618 avocadyne 43.43 µM -0.808985120885105 0.19657791550883 no 2702 0.209261852419753 3777 3015189
SGTC_16 erodoxin 22.806 µM -0.813181958788114 0.195373387885508 no 2703 0.208056870788687 3879 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_894 0960-0238 55.9 µM -0.814748122623463 0.194925036990799 no 2704 0.207608250709876 3801 6741907 YDL195W SEC31
SGTC_2243 6634756 200 µM -0.814928396880255 0.194873469466753 no 2705 0.207556648726374 3874 885676
SGTC_195 4234-0266 16.654 µM -0.815847902664705 0.194610573568433 no 2706 0.207293565910337 3853 2303354
SGTC_111 0083-0039 52.457 µM -0.815871815616248 0.194603739496951 no 2707 0.20728672672905 3747 759313
SGTC_1838 st055369 84.5 µM -0.81639204717016 0.194455098908828 no 2708 0.207137971855574 3853 676036
SGTC_1369 1866-0067 208 µM -0.818795655122835 0.193769237636343 no 2709 0.206451505143036 3839 3531355
SGTC_2690 usnic acid 100 µM -0.820533797570141 0.193274184689149 no 2710 0.205955935172084 3856 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_8 0354-0001 70 µM -0.822415134842027 0.192739218167075 no 2711 0.205420334222196 3866 4993152
SGTC_467 ro 31-8220 72.8 µM -0.823829126086302 0.192337739696045 no 2712 0.205018327796275 3802 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_472 calcifediol 10 µM -0.824350586876085 0.19218980905744 no 2713 0.204870191391732 3904 5283731 A vitamin D metabolite.
SGTC_1836 st055642 81 µM -0.824675678448647 0.192097620664656 no 2714 0.204777871704324 3876 8571
SGTC_2177 5811945 192 µM -0.828303787485687 0.191070610410877 no 2715 0.203749239215087 3894 5343475
SGTC_821 1114-0266 29.2 µM -0.828512365686977 0.191011670628194 no 2716 0.203690197423059 3892 3123235
SGTC_1125 tnp00248 1.32998 µM -0.829350735661515 0.190774877534723 no 2717 0.203452984724746 3974 24207736
SGTC_2193 5925765 200 µM -0.830808348785482 0.190363611615667 no 2718 0.203040952753545 3845 877370
SGTC_1422 4031-0024 15.5 µM -0.832210883582256 0.189968400543626 no 2719 0.202644960848903 3824 782427
SGTC_3309 9129340 25.759 µM -0.832307525291148 0.189941187097712 no 2720 0.202617692021617 3913 17158987
SGTC_1647 st011722 22.4 µM -0.83319276452869 0.189692023131525 no 2721 0.20236801129997 3838 2854783
SGTC_46 0329-0187a 2.197 µM -0.834071215203155 0.189444968743346 no 2722 0.202120427262844 3949 46494817
SGTC_3080 9117754 49.47 µM -0.835350894550803 0.189085427822204 no 2723 0.201760084755146 3889 9550191
SGTC_2349 9023730 187.07 µM -0.837052399983668 0.188608021302238 no 2724 0.201281557331958 3886 4126287
SGTC_3091 9116372 49.47 µM -0.839530770518849 0.187913973748482 no 2725 0.200585764764459 3972 17169793
SGTC_1114 scopoletin 1.73284 µM -0.840975510654277 0.187510114535644 no 2726 0.200180826946912 3879 5280460 A coumarin with genotoxic properties.
SGTC_2654 protoveratrine a 100 µM -0.844400659924914 0.186554801814331 no 2727 0.199222776866157 3887 5702278 A heart drug and vasodilator.
SGTC_2245 6637752 200 µM -0.845686071342511 0.186197065254867 no 2728 0.198863947699034 3970 681890
SGTC_153 4077-0274 519.67 µM -0.846445544558385 0.185985899916399 no 2729 0.19865212007702 3911 3121976
SGTC_1409 3909-8004 61.9 µM -0.848488302000993 0.185418665025806 no 2730 0.198083042259624 3904 2119279
SGTC_961 1252-1571 372 µM -0.848763418529825 0.185342352538651 no 2731 0.198006474714836 3886 6813498
SGTC_953 1188-0045 9.7 µM -0.850633155156978 0.184824237213444 no 2732 0.197486582923778 3949 6144426
SGTC_1490 4089-0339 670 nM -0.850696976702581 0.184806567780572 no 2733 0.197468851529113 3836 742542
SGTC_849 0386-0493 241 µM -0.852295388828746 0.184364378913775 no 2734 0.197025082351417 3853 726119
SGTC_2097 5376186 200 µM -0.852297902280699 0.184363684104692 no 2735 0.197024385014241 3849 742755
SGTC_1717 st033143 58.0435 µM -0.854108172957784 0.183863682961649 no 2736 0.196522527935036 3919 674616
SGTC_762 1165-0429 115 µM -0.855172905565208 0.183569996070151 no 2737 0.196227716720085 3868 5967793
SGTC_1760 st045453 10.4495 µM -0.855475505576763 0.183486582806577 no 2738 0.196143979500508 3974 3323419 YIL048W NEO1
SGTC_1484 3473-2379 286 µM -0.856950809966778 0.183080245958377 no 2739 0.195736035231129 4019 671917
SGTC_3154 9100113 49.47 µM -0.85720709297817 0.183009716285297 no 2740 0.195665221590341 3949 25237525
SGTC_1975 st070967 30.8 µM -0.857613347380741 0.182897948883309 no 2741 0.195553001179335 3869 261391
SGTC_1842 st055362 61.2 µM -0.858777580881752 0.18257788475103 no 2742 0.195231619343803 3880 676032
SGTC_24 0417-1663 219 µM -0.861351334924592 0.181871565954822 no 2743 0.194522285140526 3893 4329390
SGTC_550 4123-0385 25.7 µM -0.861632715861819 0.181794449973496 no 2744 0.19444483095471 3927 5731123
SGTC_1489 4065-0444 182 µM -0.864977079038256 0.180879452105472 no 2745 0.193525684705857 3873 2877968
SGTC_3238 9133470 49.47 µM -0.865647642511676 0.18069633791678 no 2746 0.193341710219798 3910 3534688
SGTC_1810 st050138 53 µM -0.865877881542986 0.180633492184645 no 2747 0.19327856690872 3874 3444541
SGTC_1294 1000-1494 117 µM -0.865910372219082 0.180624624677707 no 2748 0.193269657317994 3916 712797 YDL207W GLE1
SGTC_2025 5147754 141 µM -0.865921165396247 0.180621679013834 no 2749 0.193266697669238 3900 315777 YLR208W SEC13
SGTC_1936 st074407 74.3 µM -0.867521831086231 0.18018516037416 no 2750 0.192828077754401 3964 809813
SGTC_1028 k015-0029 4.8 µM -0.867774801080541 0.180116233397169 no 2751 0.192758813736575 3880 4588309
SGTC_1654 st012436 41.8 µM -0.868678386582007 0.179870167766112 no 2752 0.192511533194872 3870 4323132
SGTC_1875 nocodazole 6 µM -0.870261232162288 0.179439634268996 no 2753 0.192078829981747 3904 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1073 triclabendazole 3.09 µM -0.871603162998555 0.179075137388483 no 2754 0.191712452277284 3999 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2662 daunorubicin 22.37 µM -0.871803369483581 0.179020797020016 no 2755 0.191657828054052 3817 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1182 1222-0449 220 µM -0.87188462202385 0.178998746284075 no 2756 0.19163566187689 3934 658318
SGTC_420 mitomycin C 81.9 mM -0.872785990406696 0.178754242907525 no 2757 0.191389868549687 3912 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1590 st077108 57.8 µM -0.873030439566648 0.178687970379486 no 2758 0.191323243245853 3935 5489485
SGTC_2958 9077254 16.72 µM -0.873990957721219 0.178427714481548 no 2759 0.191061589023378 4000 16457351
SGTC_1574 spiramycin 23.7 µM -0.874334910326329 0.178334577364596 no 2760 0.190967946469084 3909 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1224 0823-0416 294 µM -0.876914529061464 0.177637032713377 no 2761 0.190266531999436 4023 3598164
SGTC_447 ml7 120 µM -0.876935360897314 0.17763140667489 no 2762 0.190260874142578 3959 4216 Selective myosin light chain kinase inhibitor.
SGTC_3014 9081533 49.47 µM -0.879695498123409 0.176886973023697 no 2763 0.189512144414687 3992 21367265
SGTC_83 0170-0301 39.027 µM -0.881093602957262 0.176510645115306 no 2764 0.189133579685001 3870 3089716
SGTC_555 4296-0685 37 µM -0.881287537390346 0.176458483802845 no 2765 0.189081104878193 3887 2908540 YHR072W ERG7
SGTC_2018 5133068 143 µM -0.881552405435091 0.176387259681757 no 2766 0.189009451332399 3924 785362
SGTC_300 r073-0011 5.04 µM -0.881968605221588 0.176275378574417 no 2767 0.188896892496378 3934 2735780
SGTC_2978 9011784 42.97 µM -0.886277508049161 0.175119717388159 no 2768 0.187734003043505 3954 2994934
SGTC_758 0868-0029 16 µM -0.887268475413914 0.1748546181136 no 2769 0.187467186881142 4020 762687
SGTC_802 4112-3352 742 µM -0.887633848612856 0.174756939366805 no 2770 0.187368869976998 4032 704594
SGTC_1946 st076057 65.1 µM -0.888458597090295 0.174536578758753 no 2771 0.187147058708618 3827 953009
SGTC_2728 chlorpromazine 9.18 µM -0.888764480568144 0.17445489609341 no 2772 0.187064834442184 3957 2726 A thorazine and dopamine antagonist.
SGTC_541 4513-1321 94 µM -0.890465624006854 0.17400106843095 no 2773 0.186607959416845 3956 747515
SGTC_1906 st060206 94.7 µM -0.890563967345343 0.173974855561353 no 2774 0.186581568550569 3978 5133468
SGTC_2028 5153890 36.43 µM -0.890797840146576 0.173912528153663 no 2775 0.186518817042339 3924 2830968 YPR165W RHO1
SGTC_2409 alverine citrate 63.97 µM -0.89265675418292 0.173417630190204 no 2776 0.186020508027744 4148 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1754 st042065 16.137 µM -0.89273081079541 0.173397932713089 no 2777 0.186000673183398 3815 1126236 YIL048W NEO1
SGTC_845 0330-0138 4.51 µM -0.893647599498965 0.173154204458029 no 2778 0.185755235027205 3915 9039800
SGTC_659 k018-0002 107 µM -0.894004967278834 0.173059257373205 no 2779 0.185659616729485 3971 6797879 YHR007C ERG11
SGTC_808 0711-0032 135 µM -0.894706947797603 0.172872848597967 no 2780 0.185471881836134 3893 4252555
SGTC_829 1635-0120 117 µM -0.895668711413668 0.172617663045009 no 2781 0.185214862959245 3977 285054
SGTC_3055 9094636 49.47 µM -0.896318370601372 0.172445424406533 no 2782 0.185041375181898 3970 25236176
SGTC_2749 bexarotene 57.39 µM -0.896777928144709 0.172323652025802 no 2783 0.184918713950743 4007 82146 An retinoic acid receptor inhibitor.
SGTC_2881 9058953 51.95 µM -0.898319113060842 0.171915673398606 no 2784 0.184507722834308 3929 17122249
SGTC_2917 7979103 53.79 µM -0.898381464307839 0.171899180922578 no 2785 0.184491107458535 4032 2980565
SGTC_337 1315-0038 354 µM -0.90011694039046 0.171440537039458 no 2786 0.184029010871183 3941 1626437
SGTC_385 1494-0393 12.4 µM -0.901420617240976 0.171096522043035 no 2787 0.183682361727629 3962 3090647
SGTC_812 4251-0442 148 µM -0.902569285820303 0.170793776861871 no 2788 0.183377266849586 3976 5723007
SGTC_2497 7-hydroxyflavone 100 µM -0.905801225158025 0.169943801644919 no 2789 0.182520536221592 4014 5281894
SGTC_536 3852-0578 10.6 µM -0.906143169757181 0.169854031743153 no 2790 0.182430039159436 4042 2869208
SGTC_2736 butenafine 14.65 µM -0.907396053869127 0.169525374909529 no 2791 0.182098697729916 3924 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2394 5221648 200 µM -0.908591013578376 0.169212293246656 no 2792 0.181783025927033 4051 788586
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.909668721201446 0.168930250429373 no 2793 0.181498622316376 4009 551469
SGTC_729 4092-0585 94.1 µM -0.911034809185847 0.168573170954245 no 2794 0.181138516568078 3997 2169061
SGTC_3160 9100216 49.47 µM -0.912238182574486 0.168259025448724 no 2795 0.180821674020433 3882 17191039
SGTC_2438 5259590 200 µM -0.913804696730429 0.167850645149005 no 2796 0.1804097390401 4008 1201127
SGTC_3218 9131285 49.47 µM -0.915864259318789 0.167314702090849 no 2797 0.179869047321407 3942 17156417
SGTC_2403 6032726 181.2 µM -0.917218025788572 0.166963023955012 no 2798 0.179514201430227 4043 2881040
SGTC_852 0418-0143 439 µM -0.917556041981684 0.166875289368773 no 2799 0.179425670163672 4010 5369229
SGTC_2134 5324836 1.464 µM -0.921893219385007 0.165752182751649 no 2800 0.17829213816958 3963 699272
SGTC_224 benfluorex 43.875 µM -0.922247698602718 0.165660607327937 no 2801 0.178199694061922 4000 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1415 3966-0071 78.1 µM -0.9244252550072 0.165098779873758 no 2802 0.177632475372681 3936 2893185
SGTC_1023 4482-3888 16 µM -0.924895506003345 0.164977613390216 no 2803 0.177510132242142 4028 3303168
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.929703464398155 0.163742083395026 no 2804 0.176262320129207 4037 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2419 paclitaxel 166.5 µM -0.932233193863981 0.163094421377929 no 2805 0.175608012212159 3945 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_757 1066-0008 322 µM -0.932397029289499 0.163052533674881 no 2806 0.175565689742017 4053 6842497
SGTC_1808 st050063 61.5 µM -0.932705265411901 0.162973746089661 no 2807 0.175486082762967 3972 4011993
SGTC_518 1021-0119 62.6 µM -0.933343618152298 0.162810656810301 no 2808 0.175321290581251 3987 1097762
SGTC_3092 9117248 49.47 µM -0.935000079817505 0.162387951621941 no 2809 0.174894129146141 4095 17141857
SGTC_1144 3486-0183 12.5 µM -0.93567282776741 0.162216480169827 no 2810 0.174720832461497 3996 6744069
SGTC_2441 5730946 39.09 µM -0.936222153375229 0.162076554333787 no 2811 0.174579409663507 4074 1774275
SGTC_459 nigericin 15.3 µM -0.937022750895897 0.161872764584413 no 2812 0.174373427618608 4077 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2719 novobiocin 32.65 µM -0.937280514529771 0.161807187151878 no 2813 0.17430714167304 4015 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_440 fluspirilene 35.1 µM -0.9386602107609 0.161456474133928 no 2814 0.173952614183251 4117 3396 An atypical antipsychotic.
SGTC_2587 piperic acid 92.2 µM -0.938948149265247 0.161383343933585 no 2815 0.173878683218208 4024 5370536
SGTC_3264 9137442 49.47 µM -0.939504022710319 0.161242225125018 no 2816 0.173736013927931 4022 17015726
SGTC_856 0433-0016 11.3 µM -0.939806345545179 0.16116550865897 no 2817 0.173658451667841 4071 3911780
SGTC_2337 9009472 200 µM -0.941637214401269 0.160701422194231 no 2818 0.173189204971578 3969 5742383
SGTC_877 0771-0151 33.1 µM -0.942052957679532 0.160596161786307 no 2819 0.173082763706316 4050 6166523
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.942345140040946 0.160522212234402 no 2820 0.173007982240184 4064 6708784 An antioxidant flavonoid
SGTC_1010 4112-3296 15.2 µM -0.943309974514343 0.160278176622571 no 2821 0.17276118771278 4103 704384
SGTC_827 3253-0474 693 µM -0.945793884099473 0.159651037567756 no 2822 0.172126862796765 4060 5402065
SGTC_2139 5578692 56.4705 µM -0.946076048522967 0.159579898222164 no 2823 0.172054899591583 3984 650991 YMR113W FOL3
SGTC_2064 5220758 200 µM -0.946735502225271 0.159413717552708 no 2824 0.171886787446399 4096 788518
SGTC_3230 9131665 49.47 µM -0.94813320940167 0.159061873558253 no 2825 0.171530821891209 3985 15943720
SGTC_2371 9071574 200 µM -0.949810903019559 0.15864022110444 no 2826 0.171104172424051 4045 45596039
SGTC_260 nsc-65238 3.989 µM -0.950458354357338 0.158477694216989 no 2827 0.170939702586422 4023 3246252
SGTC_2135 5326629 150.42 µM -0.950896369268749 0.158367803200381 no 2828 0.170828492542919 4000 5020077
SGTC_2694 st077685 81.9 µM -0.951180956685464 0.158296431514707 no 2829 0.170756261878694 3985 2838096
SGTC_2451 5856223 45.7 µM -0.951235468207647 0.158282762977448 no 2830 0.170742428629855 4009 2179896
SGTC_1180 1193-0155 285 µM -0.95224201809159 0.158030513959972 no 2831 0.170487127959281 4107 2921347
SGTC_1738 st035555 74 µM -0.960067505630461 0.156078393923088 no 2832 0.168510620607379 4112 5331140
SGTC_1336 1486-0901 104 µM -0.960245368415065 0.156034210353939 no 2833 0.168465869165949 4063 5006114
SGTC_1000 4048-0884 8.67 µM -0.961993716787294 0.155600335299195 no 2834 0.168026380071415 4100 13040088
SGTC_2049 5262831 67.185 µM -0.962943567799224 0.155364951524831 no 2835 0.167787921959606 4059 763417
SGTC_3268 9137683 49.47 µM -0.963622673439899 0.15519680563213 no 2836 0.167617567558684 4079 1953228
SGTC_2912 7964298 10.93 µM -0.965755571856887 0.154669483479778 no 2837 0.167083252322441 4065 2975850
SGTC_2033 5192550 145 µM -0.969662309851084 0.153706684117435 no 2838 0.166107421570499 4042 182073
SGTC_1093 fluphenazine 7.97 µM -0.973202557412187 0.152837638959613 no 2839 0.165226320019627 4052 6602611 An atypical antipsychotic.
SGTC_1126 isoteolin 1.0172 µM -0.973812307113154 0.152688289729015 no 2840 0.165074870608031 3998 133323
SGTC_1859 st055998 20 µM -0.975306290476406 0.152322769762384 no 2841 0.164704175550002 3979 676301
SGTC_913 3487-1245 167 µM -0.979666353679633 0.151259354493317 no 2842 0.163625419868643 3989 4016153
SGTC_1341 1486-1360 280 µM -0.980316720881893 0.151101154820162 no 2843 0.163464901739643 4047 3976547
SGTC_386 1509-0011 3.07 µM -0.981100270906988 0.150910705132339 no 2844 0.163271648433226 4068 3107280
SGTC_1111 tnp00062 510.699 nM -0.981185509297654 0.150889996727361 no 2845 0.163250634352823 4113 676306
SGTC_3349 9149703 23.001 µM -0.981389591300782 0.150840423318327 no 2846 0.16320032853526 4082 4910494
SGTC_538 2922-0838 53.3 µM -0.981656884166446 0.150775511806573 no 2847 0.163134456601068 4051 777039
SGTC_2014 4013930 200 µM -0.982164712708058 0.150652237949696 no 2848 0.163009354409924 3994 64556
SGTC_2378 9074213 121.43 µM -0.983219284160224 0.150396458359133 no 2849 0.162749762858367 4038 657714
SGTC_1179 1021-1431 9.29 µM -0.98647071771975 0.149609666059011 no 2850 0.161951088829279 4109 2840958
SGTC_734 2023-0417 80 µM -0.986471214109811 0.149609546151026 no 2851 0.161950967092518 4072 3935732
SGTC_48 0382-0018 55 µM -0.988835416079234 0.149039176959647 no 2852 0.161371836653195 4108 762596
SGTC_3015 9080845 49.47 µM -0.989827207122929 0.148800338130516 no 2853 0.161129292034632 4128 5296973
SGTC_2294 7971431 200 µM -0.991856404055329 0.148312473161405 no 2854 0.160633789179548 4065 5741572
SGTC_2974 9094440 9.66 µM -0.992072790214475 0.148260512225903 no 2855 0.16058100934633 4127 25236134
SGTC_2781 5567276 71.43 µM -0.992440091816697 0.148172339761024 no 2856 0.160491444906947 4131 2853274
SGTC_1912 st060209 90.8 µM -0.993737899127495 0.147861076109291 no 2857 0.160175243294328 4099 688787
SGTC_1608 st001473 40.5 µM -0.995609239529189 0.147413028596993 no 2858 0.159720021866149 4056 7292267
SGTC_2819 7996655 46.38 µM -0.99572420214576 0.147385533252207 no 2859 0.159692083737908 4042 6456960
SGTC_2980 9014342 25.29 µM -0.997641599872306 0.146927460288971 no 2860 0.159226590645212 4152 2996599
SGTC_946 3434-1334 87.4 µM -0.999665830948326 0.14644490168004 no 2861 0.158736126569311 4085 4047976
SGTC_1845 st056753 3.01 µM -1.00386680579681 0.145446825498006 no 2862 0.157721409122493 4050 5375839
SGTC_3124 9127567 49.47 µM -1.00477979514876 0.145230522248557 no 2863 0.157501447510766 4094 17592030
SGTC_325 2810-4341 181 µM -1.00505432516343 0.145165523604005 no 2864 0.157435345913169 4090 774970
SGTC_2616 abietic acid 100 µM -1.00520133872585 0.14513072423105 no 2865 0.157399955345611 4123 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2007 4011539 71.82 µM -1.00542157777894 0.145078602261457 no 2866 0.157346946994773 4062 45595301
SGTC_31 0508-1974 57.237 µM -1.00832787322958 0.144391975915189 no 2867 0.156648543070564 4021 6810525
SGTC_690 glyoxal 20.3 µM -1.01658538805831 0.142453064934851 no 2868 0.154675354106171 3914 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.01777535011485 0.142175113731677 no 2869 0.154392364486446 4169 165506
SGTC_1635 st007035 42.4 µM -1.01805505265942 0.142109834152517 no 2870 0.154325897027686 4077 3716403
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.01893905950711 0.141903649815423 no 2871 0.154115949391054 4114 688751
SGTC_514 4466-0038 2.65 nM -1.0228063209247 0.141004038024335 no 2872 0.153199714411424 3943 5722064
SGTC_2287 7945887 168.79 µM -1.02384945476643 0.140762045533869 no 2873 0.152953193639718 4133 1245853
SGTC_2622 2-methoxyxanthone 59.94 µM -1.02488901264469 0.140521163132442 no 2874 0.152707779760004 4121 71034 A hepatoprotective.
SGTC_284 0988-0104 32.6 µM -1.02581470585474 0.140306900687344 no 2875 0.152489466473741 4106 4666532
SGTC_2768 sulfasalazine 50.2 µM -1.02702766417624 0.140026483387982 no 2876 0.152203718905069 4046 5384001 An antioxidant and salicylic acid derivative.
SGTC_741 4582-0002 126 µM -1.02744692535946 0.139929645277137 no 2877 0.152105032488652 4103 2912688
SGTC_1056 3448-1962 115 µM -1.0296611519396 0.139418973208059 no 2878 0.151584548971005 4130 715507
SGTC_1017 4239-0030 168 µM -1.03033826208707 0.139263063207512 no 2879 0.151425621851574 4142 1149593
SGTC_1305 1181-0477 144 µM -1.03170561072877 0.138948582102845 no 2880 0.15110502410842 4192 6252086
SGTC_2343 7990716 14.84 µM -1.03456205886363 0.138293179080304 no 2881 0.150436740297126 4116 6456862
SGTC_89 0302-0250 142.109 µM -1.03507139582695 0.138176535071355 no 2882 0.15031778491937 4217 4203518 YLR208W SEC13
SGTC_1355 1499-0035 1.68 µM -1.0367087264589 0.137802022086599 no 2883 0.149935811930303 4122 1548538
SGTC_2057 5236571 38.335 µM -1.03970700983452 0.137118009886951 no 2884 0.149238021438307 4122 54684039 YBR257W POP4
SGTC_1784 st039334 36.3 µM -1.04131871571654 0.136751284143175 no 2885 0.148863826675499 4196 3496984
SGTC_521 r062-0005 13.8 µM -1.04133180775317 0.136748307943987 no 2886 0.148860789626041 4047 2832033
SGTC_779 1360-0071 233 µM -1.04135161628577 0.136743804974882 no 2887 0.148856194583699 4187 7566
SGTC_663 1486-0733 13.9 µM -1.04291680436973 0.136388319463469 no 2888 0.14849341302132 4138 722445 YPR165W RHO1
SGTC_853 0419-0306 21 µM -1.0435646070616 0.136241375658001 no 2889 0.14834343750662 4166 762713
SGTC_27 0485-0001 32.618 µM -1.04374117679132 0.136201342399908 no 2890 0.148302576686727 4070 2054479
SGTC_1395 3486-0190 4.35 µM -1.04421897436725 0.136093052797232 no 2891 0.148192045089258 4129 6748079
SGTC_1286 0929-0070 131 µM -1.05021345367402 0.134739451608814 no 2892 0.146809992687187 4213 1420408
SGTC_187 1488-2104 32.728 µM -1.05157754961851 0.134432722653443 no 2893 0.146496706229065 4153 2852859
SGTC_743 1275-0778 158 µM -1.0516749347696 0.13441084309617 no 2894 0.146474357346195 4132 2849257 YMR203W TOM40
SGTC_633 0437-0093 97.7 µM -1.05406151429196 0.133875413490238 no 2895 0.145927377366763 4070 2831118
SGTC_2090 5301565 104.445 µM -1.05428196531201 0.133826029320422 no 2896 0.145876921553041 4146 2056344
SGTC_545 4218-0007 221 µM -1.05566952349974 0.13351548395772 no 2897 0.14555961278006 4150 2840508
SGTC_391 gliotoxin 8.33 µM -1.05567689343707 0.133513835837755 no 2898 0.145557928652422 4236 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1877 wortmannin 25 µM -1.05898370336905 0.132775753745811 no 2899 0.144803600810248 4152 312145 A covalent inhibitor of PI 3-kinase.
SGTC_680 0417-1641 114 µM -1.05934345771584 0.132695626155079 no 2900 0.144721695063951 4127 2835990
SGTC_3267 9137951 49.47 µM -1.06211445753176 0.132079561460658 no 2901 0.144091863752143 4197 16643986
SGTC_800 3448-7362 155 µM -1.06253082354491 0.131987163280196 no 2902 0.143997386273567 4224 15991913
SGTC_732 3970-1727 52.7 µM -1.06253948405357 0.131985241850228 no 2903 0.143995421563968 4224 1275699
SGTC_2471 5466956 24.79 µM -1.06261765897695 0.131967898748818 no 2904 0.143977687739908 4130 724419
SGTC_3244 9134489 49.47 µM -1.06323787520209 0.131830359523307 no 2905 0.143837045140382 4161 16584271
SGTC_2815 7968870 71.43 µM -1.06541918496754 0.131347417676652 no 2906 0.14334313941071 4133 2977326 YHR190W ERG9
SGTC_1491 4138-0063 26.5 µM -1.06802697888504 0.130771657258193 no 2907 0.14275417112396 4131 23883227
SGTC_2217 6934799 96.0675 µM -1.06875935395362 0.130610274448325 no 2908 0.142589059416055 4136 675606
SGTC_1889 st059080 5.18 µM -1.0714862600933 0.130010597077231 no 2909 0.141975422713071 4131 176925 Isolated from Daphnopsis sellowiana.
SGTC_375 3970-0961 9.27 µM -1.0742458580334 0.129405673369977 no 2910 0.141356252015198 4110 2898222
SGTC_2713 st079149 53.4 µM -1.0748625161907 0.129270764512108 no 2911 0.141218143053785 4176 3103253
SGTC_2081 5214970 32.255 µM -1.07815176566481 0.128552808721067 no 2912 0.140483016680745 4135 2063512
SGTC_2681 menadione 3.18 µM -1.07911084694956 0.12834398884689 no 2913 0.140269158186002 4203 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1867 st057372 64 µM -1.08501381239237 0.127063927463011 no 2914 0.13895776887986 4130 688837
SGTC_587 k089-0003 57 µM -1.08734946182831 0.126559902036284 no 2915 0.138441198524069 4050 9659696
SGTC_1552 6-methylflavone 10.6 µM -1.08853962699614 0.126303604650374 no 2916 0.13817847632812 4100 689013
SGTC_189 3970-0742 2.116 µM -1.08867442261775 0.126274599762347 no 2917 0.138148742405879 4109 2891807
SGTC_2658 polymyxin b sulfate 77.05 µM -1.08892967587555 0.126219687906426 no 2918 0.138092449262743 4216 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1548 st061468 90.8 µM -1.09106100347143 0.125761831530549 no 2919 0.137623020324411 4180 390799
SGTC_1361 1608-0041 5.61 µM -1.09137260908762 0.125694988938956 no 2920 0.137554479965979 4147 X1361
SGTC_142 0335-0849 62.6745 µM -1.09188052961812 0.125586087924371 no 2921 0.137442808392399 4195 3889043 YPR107C YTH1
SGTC_3077 9117319 49.47 µM -1.09232133773042 0.125491629566015 no 2922 0.137345942360934 4160 17154678
SGTC_864 0469-0573 172 µM -1.09282625779704 0.125383493945988 no 2923 0.137235045249227 4173 689425
SGTC_2273 7815444 169.05 µM -1.09517042604052 0.124882309910839 no 2924 0.136720989742096 4148 2824616
SGTC_446 go6976 132 µM -1.09555836677364 0.124799503212172 no 2925 0.136636044871414 4207 3501 A protein kinase C inhibitor.
SGTC_70 0141-0289 43.283 µM -1.09784075391681 0.124313100174417 no 2926 0.136137016118668 4159 352408
SGTC_2316 5844804 197.44 µM -1.10048034159999 0.123752228822903 no 2927 0.135561445127795 4205 776813
SGTC_860 0443-0016 25.1 µM -1.10230098276613 0.123366404767633 no 2928 0.135165421130767 4217 5337942
SGTC_3313 9133968 57.047 µM -1.10347459371036 0.123118144301406 no 2929 0.134910559367172 4191 1494643
SGTC_235 0330-0087 5 mM -1.1043153896973 0.122940501472115 no 2930 0.134728174621396 4226 46494818 YHR062C RPP1
SGTC_1971 st069429 63.5 µM -1.10696441433358 0.122381992587607 no 2931 0.134154657078768 4182 1246522 YGL099W LSG1
SGTC_895 0964-0006 13.7 µM -1.10841081613198 0.122077792210545 no 2932 0.133842217909118 4176 6738897
SGTC_1016 4226-1401 38 µM -1.11018155129649 0.121706103007673 no 2933 0.133460400475527 4162 2901613
SGTC_2121 5257820 149.641 µM -1.1132030745379 0.121073702590375 no 2934 0.13281061126097 4259 791256
SGTC_2782 7736369 71.43 µM -1.11680300631004 0.120323264418321 no 2935 0.132039281582936 4238 2950836 YOL077C BRX1
SGTC_1511 0906-3109 28.5 µM -1.11731226560112 0.120217369859293 no 2936 0.131930416440809 4222 2882180
SGTC_2051 5263410 176 µM -1.1183029519466 0.120011556287774 no 2937 0.131718813302106 4196 227584
SGTC_1618 st003135 44.5 µM -1.11838886649211 0.119993719382317 no 2938 0.131700473643978 4184 1270615
SGTC_1645 Cervolide 78 µM -1.11948666773308 0.11976596695453 no 2939 0.131466287753755 4210 23173 A fragrance.
SGTC_2442 5158906 48.48 µM -1.120249281682 0.119607932803287 no 2940 0.131303774221927 4222 1893835
SGTC_1730 st033808 45.1 µM -1.12253137500823 0.119135900425592 no 2941 0.130818287559904 4149 1045166
SGTC_3336 9143619 71.43 µM -1.12330247383573 0.118976702573058 no 2942 0.130654526762619 4255 45595730
SGTC_2947 9072639 7.68 µM -1.1246309844511 0.118702776273496 no 2943 0.130372719143139 4213 16488146
SGTC_3165 9101544 49.47 µM -1.12925911215818 0.117751981045373 no 2944 0.12939427194905 4233 5002184
SGTC_299 1273-0059 1.44 µM -1.13085465000035 0.117425448976513 no 2945 0.129058136775114 4051 2848077
SGTC_2553 4-methylesculetin 85.09 µM -1.13128143045308 0.117338215746678 no 2946 0.128968328804419 4247 5319502
SGTC_1155 4088-0394 48.2 µM -1.13362874689842 0.116859248468505 no 2947 0.128475154690381 4190 2326248
SGTC_1249 0481-0015 10.2 µM -1.1339436679202 0.11679509477531 no 2948 0.128409089118062 4162 4227577
SGTC_209 4077-0173 175.592 µM -1.13705875813739 0.116161853240721 no 2949 0.127756861587451 4206 15993494
SGTC_571 k831-0106 44.2 µM -1.13840975816871 0.115887978252895 no 2950 0.127474710632421 4097 4783639
SGTC_724 3910-0327 137 µM -1.13878411925066 0.115812168893653 no 2951 0.127396603547751 4275 2885483
SGTC_1852 st056254 31.4 µM -1.13969371259561 0.115628119984026 no 2952 0.127206963754231 4173 442583
SGTC_1038 k292-0204 154 µM -1.14143164717858 0.115277040850586 no 2953 0.126845170634088 4183 4454212
SGTC_2260 7964312 200 µM -1.14316061610278 0.114928525395634 no 2954 0.126485955384143 4291 231951
SGTC_2676 harmalol 100 µM -1.14373738211146 0.114812431144656 no 2955 0.126366282707927 4191 5459187 A monoamine oxidase inhibitor
SGTC_3072 9116419 49.47 µM -1.14997113046335 0.113562993551983 no 2956 0.1250778810205 4284 17170162
SGTC_158 k038-0087 26.446 µM -1.15115817332682 0.113326176111892 no 2957 0.12483358456205 4159 X158
SGTC_110 0850-0284 111.64 µM -1.15505290754302 0.112551643344017 no 2958 0.12403438058768 4051 3906265
SGTC_3085 9117376 49.47 µM -1.15572055941881 0.112419250198265 no 2959 0.123897737938931 4337 16480349
SGTC_1525 8-methoxypsoralen 92.5 µM -1.15579648544485 0.11240420136872 no 2960 0.123882205477645 4304 4114 Related to psoralen; DNA damaging agent.
SGTC_1785 bathophenanthroline 24 µM -1.15650443513697 0.112263952297669 no 2961 0.123737443253165 4166 72812 An iron chelator.
SGTC_1061 3448-9325 110 µM -1.15752568294868 0.112061857380026 no 2962 0.123528826247621 4196 723482
SGTC_2799 7812892 81.82 µM -1.15870096802323 0.111829602046078 no 2963 0.123289048063562 4277 20205235
SGTC_1840 st055363 71 µM -1.15915938471028 0.111739104889306 no 2964 0.123195611713125 4277 676033
SGTC_2388 9080168 200 µM -1.15920059122221 0.11173097277802 no 2965 0.123187215266084 4251 15943073
SGTC_2105 5350118 200 µM -1.16311461493405 0.110960468524997 no 2966 0.122391501599593 4225 2133313
SGTC_1849 st056239 19.2 µM -1.16378237263912 0.110829396498594 no 2967 0.122256108734331 4246 5393181
SGTC_3048 9093155 49.47 µM -1.16679930935915 0.110238594390268 no 2968 0.121645712997978 4236 25236002
SGTC_1486 3970-0793 4.53 µM -1.17155584991025 0.10931172208195 no 2969 0.120687711238679 4288 2844330
SGTC_1748 st037455 53.6035 µM -1.17169952306885 0.109283812913144 no 2970 0.120658857293341 4306 580690
SGTC_2478 5763493 32.33 µM -1.17197087951549 0.109231114646962 no 2971 0.120604373904881 4199 1365576 YLR208W SEC13
SGTC_438 sphingosine 6.67 µM -1.17226505839318 0.109174004822536 no 2972 0.120545327762562 4197 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2666 tannic acid 100 µM -1.17509462599583 0.108625787844177 no 2973 0.119978430215079 4253 16134267 A thiamine antagonist.
SGTC_1646 st011709 75.6 µM -1.17751152060845 0.108159094775503 no 2974 0.119495700994152 4221 5757843
SGTC_329 k048-0121 21.3 µM -1.1788946271613 0.107892672423956 no 2975 0.119220068722161 4281 6832902
SGTC_2537 larixol 68.93 µM -1.18256033277566 0.107188849112004 no 2976 0.118491720602636 4247 6708759
SGTC_1794 st048918 76.9 µM -1.18393542677293 0.10692568387867 no 2977 0.118219312561007 4193 672303
SGTC_1492 4158-0558 28.5 µM -1.18530032154336 0.106664931830053 no 2978 0.117949363208634 4284 3967268
SGTC_2671 danthron 100 µM -1.18728717125814 0.106286181113261 no 2979 0.117557183289109 4267 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1703 st026983 48.3 µM -1.18907865448119 0.10594550646499 no 2980 0.117204358573734 4303 1104023
SGTC_1162 k048-0130 20.1 µM -1.18934323180688 0.105895260476752 no 2981 0.117152314876892 4234 6797406
SGTC_1065 prochlorperazine maleate 2.48 µM -1.18952753396979 0.105860269755985 no 2982 0.11711607138603 4317 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2224 6650123 117.647 µM -1.1908924906866 0.105601385750312 no 2983 0.116847896437587 4282 2908370
SGTC_2925 9010536 32.5 µM -1.19467146000632 0.104887037891351 no 2984 0.116107708678384 4196 2994177
SGTC_3107 9121808 49.47 µM -1.19576090694512 0.104681748247822 no 2985 0.115894937762164 4224 662681
SGTC_889 0919-1524 82.7 µM -1.19700052603714 0.104448515085872 no 2986 0.115653174857633 4295 3905452
SGTC_1136 pergolide 1.05886 µM -1.19884940423553 0.104101350338386 no 2987 0.115293254142083 4238 47811 A dopamine receptor agonist.
SGTC_1151 3909-8316 15.3 µM -1.20121423717454 0.103658524891112 no 2988 0.114834054050923 4327 800431
SGTC_1279 0874-0590 65.2 µM -1.2016115564637 0.103584259398206 no 2989 0.114757030963957 4338 3523074
SGTC_210 3551-0445 56.827 µM -1.20530235973502 0.102896232287174 no 2990 0.114043299494574 4326 2865180 YOR207C RET1
SGTC_795 0685-0265 78 µM -1.20546721239166 0.102865578660458 no 2991 0.114011494055635 4296 302754
SGTC_2141 5621638 7.665 µM -1.20687337457328 0.102604378627899 no 2992 0.11374045646253 4307 2856238
SGTC_3306 9127676 59.7925 µM -1.20769391208017 0.102452183557323 no 2993 0.113582510304399 4257 41905287
SGTC_1070 indatraline 8.81 µM -1.21039085376283 0.101953105497941 no 2994 0.113064474912134 4326 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1623 st003709 20.3 µM -1.21092292566823 0.101854853128656 no 2995 0.112962472642872 4271 16192618
SGTC_1594 piperine 70.1 µM -1.21299388987697 0.101473085169629 no 2996 0.112566078297013 4277 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_117 lucigenin 22.078 µM -1.21632865966616 0.100860535452031 no 2997 0.111929874079765 4286 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.2182473229957 0.100509328481911 no 2998 0.111565000639732 4336 688664
SGTC_324 1315-0088 19.6 µM -1.221449606204 0.0999251465397849 no 2999 0.110957917424692 4265 6787421
SGTC_156 3474-0145 5.642 µM -1.22290797703953 0.0996599241256795 no 3000 0.110682227647802 4203 2265471
SGTC_1698 5-fluorocytosine 1.055 µM -1.22782708067481 0.0987691193788441 no 3001 0.10975594373681 4325 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3023 9089636 49.47 µM -1.23376406218976 0.097701763803945 no 3002 0.108645417272159 4379 17249241
SGTC_152 4469-0003 551.229 µM -1.23467186530342 0.0975393064352532 no 3003 0.108476325429726 4290 697280
SGTC_2502 avocadyne acetate 18.59 µM -1.23943764559347 0.0966896877145688 no 3004 0.107591733633128 4260 3952079
SGTC_1208 2323-2347 50.3 µM -1.2402903289258 0.096538250730592 no 3005 0.107434014096946 4319 5412760
SGTC_474 dl-dihydrosphingosine 5 µM -1.24538310222506 0.0956373986436984 no 3006 0.106495480815049 4336 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2977 9011197 71.43 µM -1.24562982509313 0.0955939138730485 no 3007 0.106450163734848 4384 2704722
SGTC_3115 9123671 49.47 µM -1.24602509330704 0.0955242783956565 no 3008 0.106377591457197 4461 3286988
SGTC_2634 4'-methoxyflavone 100 µM -1.24619959095964 0.0954935485503249 no 3009 0.106345564602112 4329 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2138 5575593 77.673 µM -1.24674491316801 0.0953975616808197 no 3010 0.106245522435417 4324 762213
SGTC_3099 9120367 49.47 µM -1.24872587595949 0.0950494729338838 no 3011 0.105882676612331 4361 24824940
SGTC_1954 st077032 68.9 µM -1.24885592360218 0.0950266541253948 no 3012 0.105858887619752 4276 698907
SGTC_1092 toremifene 6.32 µM -1.24889199378662 0.0950203257856769 no 3013 0.105852290157994 4317 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3217 9129673 49.47 µM -1.2520307214059 0.0944708393148115 no 3014 0.105279334874305 4335 17248312
SGTC_721 1187-1332 279 µM -1.25276950605443 0.0943418440813293 no 3015 0.105144801147237 4286 25730
SGTC_1338 1486-1223 76 µM -1.25399215691285 0.0941286490061703 no 3016 0.104922428100279 4339 3444526
SGTC_2281 7943571 200 µM -1.25457229857951 0.0940276134460446 no 3017 0.104817032399258 4424 1244024
SGTC_190 3970-0790 3.722 µM -1.25482883704391 0.0939829610785305 no 3018 0.104770450905948 4298 2832352
SGTC_1990 st072050 59.8 µM -1.25514428815597 0.0939280759934492 no 3019 0.104713192781212 4322 17233948
SGTC_2338 7999974 200 µM -1.25718731204493 0.09357318451648 no 3020 0.104342908293292 4326 315925
SGTC_1504 k297-0033 30 µM -1.25722796955378 0.0935661320073046 no 3021 0.104335549032593 4210 4388117
SGTC_2722 naftopidil 47.16 µM -1.25733816964196 0.0935470185174858 no 3022 0.104315604026208 4268 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_752 1896-0090 130 µM -1.26080939770207 0.092946431566299 no 3023 0.103688763551216 4328 772567
SGTC_172 1112-0046 2.638 µM -1.26320674768173 0.092533312781108 no 3024 0.103257444250782 4310 2802135 YIL048W NEO1
SGTC_1497 4476-2978 41.3 µM -1.26406292250084 0.0923861037611398 no 3025 0.1031037216676 4382 1528379
SGTC_1033 k072-0102 21.3 µM -1.26656522140395 0.0919568568842113 no 3026 0.102655397336955 4302 5965931
SGTC_1365 1672-3266 55.4 µM -1.26745808727288 0.0918040518387878 no 3027 0.10249577053745 4357 6415873
SGTC_1281 0884-0031 11.8 µM -1.27060582283901 0.0912668487933567 no 3028 0.101934457205966 4359 1548255
SGTC_411 enrofloxacin 100 µM -1.27338340896744 0.0907947554847536 no 3029 0.101441010903001 4402 71188 A bacterial gyrase inhibitor.
SGTC_1375 2910-0797 186 µM -1.27378693782837 0.090726320599876 no 3030 0.101369467815851 4336 742508
SGTC_364 0083-0097 67.7 µM -1.27392577498225 0.0907027839138732 no 3031 0.101344861377004 4369 5207356
SGTC_548 1436-0017 110 µM -1.27854499823502 0.0899222808806193 no 3032 0.100528664589026 4396 9677137
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.28637006628761 0.0886114984738917 no 3033 0.099156970024662 4357 2346 DNA damaging agent; causes G2/M arrest.
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.28739262555277 0.0884412657601413 no 3034 0.0989787366930886 4357 140250 A respiratory chain inhibitor.
SGTC_2898 9056270 58.44 µM -1.28939761053502 0.0881081891403956 no 3035 0.0986299458507936 4359 19154699
SGTC_2222 6885208 172.143 µM -1.28950918072131 0.088089682132051 no 3036 0.0986105633564808 4346 609514
SGTC_907 3448-6986 75.5 µM -1.28998503873031 0.0880107804300308 no 3037 0.0985279263848482 4382 590582
SGTC_2826 7992541 19.48 µM -1.29024299758397 0.0879680304748864 no 3038 0.0984831507346638 4362 2985066
SGTC_1196 1588-0294 184 µM -1.29074650415384 0.0878846319994537 no 3039 0.0983957966425079 4368 6144269
SGTC_2110 5483698 200 µM -1.29092177580557 0.0878556146626175 no 3040 0.0983654018241508 4331 2848765 YHR062C RPP1
SGTC_2893 9048488 25.97 µM -1.291361011207 0.0877829278410666 no 3041 0.0982892618117026 4386 6467338
SGTC_1124 fisetin 1.16336 µM -1.29184605589394 0.0877027124057152 no 3042 0.0982052310742376 4362 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_940 3232-1287 54.8 µM -1.29326634855487 0.0874681425947573 no 3043 0.0979594775784691 4358 1585493 YIL048W NEO1
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.29639153967384 0.0869536478508935 no 3044 0.0974203126772813 4355 641818 YHR062C RPP1
SGTC_1003 4049-0218 100 µM -1.30056041322552 0.0862708571704503 no 3045 0.0967044823400636 4368 295161
SGTC_963 1269-2853 151 µM -1.30087650009091 0.0862192515152141 no 3046 0.0966503655611398 4342 3668223
SGTC_504 lovastatin 124 µM -1.30193039627003 0.086047354877401 no 3047 0.0964700902382516 4390 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1898 st060199 18.6 µM -1.3077756151327 0.0850986178143598 no 3048 0.0954747136945358 4345 688866
SGTC_2692 st077426 47.7 µM -1.31187678244849 0.0844376522068943 no 3049 0.0947808562305203 4374 25238571
SGTC_1572 epiandrosterone 68.9 µM -1.31407309454541 0.0840852705248216 no 3050 0.0944108037144477 4311 441302 A steroid.
SGTC_2805 7950783 58.44 µM -1.31433183226189 0.0840438308124876 no 3051 0.0943672797243601 4375 1178958 YDL195W SEC31
SGTC_157 1348-1695 65.819 µM -1.31558461630423 0.0838434004040311 no 3052 0.0941567498558464 4308 5380510
SGTC_1241 0364-0022 50.8 µM -1.31910039056467 0.0832828363245478 no 3053 0.0935677763134615 4367 4563895
SGTC_709 3807-1509 243 µM -1.32090178469228 0.0829967113474323 no 3054 0.0932670573083343 4450 1886677 YPL242C IQG1
SGTC_1927 st060202 13.8 µM -1.32178732410537 0.082856327791053 no 3055 0.0931194902447097 4305 688887
SGTC_1503 4585-0012 61.3 µM -1.32332651151073 0.0826127473851216 no 3056 0.0928634094401165 4405 2922052
SGTC_1226 3909-7979 35.4 µM -1.32360739460447 0.0825683551169129 no 3057 0.0928167340229251 4373 6615510
SGTC_2607 solasodine 47.35 µM -1.32610593805442 0.0821742618839256 no 3058 0.0924023047651745 4350 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1082 camptothecin 424.86 nM -1.32739058493727 0.0819721878941699 no 3059 0.0921897562636885 4261 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1539 benzyladenosine 56 µM -1.33291224674545 0.0811078964089253 no 3060 0.0912803015576914 4390 92208 A nucleotide analog.
SGTC_531 3788-1495 174 µM -1.3339400689588 0.0809477760146598 no 3061 0.0911117492170236 4380 2896655
SGTC_2794 7785382 27.27 µM -1.33620544729481 0.080595704290294 no 3062 0.0907410655463941 4384 2205081
SGTC_2564 betulinic acid 100 µM -1.3378771069363 0.0803366473491847 no 3063 0.0904682505001313 4423 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_586 0957-0265 8.15 µM -1.33912391693221 0.0801438393486656 no 3064 0.0902651678026264 4266 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1147 3809-1045 12.3 µM -1.34103857972589 0.0798484351965041 no 3065 0.0899539635331674 4392 325925
SGTC_3191 9110352 49.47 µM -1.34280058608737 0.0795773119692605 no 3066 0.0896682767909068 4354 17122424
SGTC_2408 sulbentine 18.36 µM -1.3433822039966 0.0794879704121569 no 3067 0.0895741231477883 4282 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2103 5378138 10 µM -1.34408967515599 0.0793793990501734 no 3068 0.0894596952157262 4470 244142
SGTC_1303 1160-0052 261 µM -1.3444838649445 0.0793189538183753 no 3069 0.0893959852816108 4336 3562476
SGTC_186 3455-3465 67.277 µM -1.34986023582007 0.0784980135801076 no 3070 0.0885304093964117 4397 755278
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.35216813950661 0.0781475926230964 no 3071 0.0881607666907192 4419 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_557 1315-0110 16.2 µM -1.35411595473061 0.0778527701587533 no 3072 0.0878496934068667 4387 6833801
SGTC_2002 4023503 131 µM -1.35412818117332 0.0778509222267573 no 3073 0.087847743387663 4388 4736863 YCR052W RSC6
SGTC_127 0180-0333 59.125 µM -1.35940253283446 0.0770568454816863 no 3074 0.0870095344759844 4316 771601
SGTC_1389 3405-0187 19 µM -1.36339292304457 0.0764601762953544 no 3075 0.0863793551342437 4392 799890
SGTC_200 k038-0079 37.545 µM -1.36636735098699 0.076017711690198 no 3076 0.0859118455255349 4401 3436683
SGTC_2962 9082311 13.18 µM -1.3691079553505 0.0756117578648722 no 3077 0.085482765972081 4382 16459453
SGTC_3046 9092212 49.47 µM -1.37158882422133 0.0752457037525871 no 3078 0.0850957374208245 4488 25236637
SGTC_3074 9116018 49.47 µM -1.37276431619253 0.075072731448489 no 3079 0.0849128136916393 4465 17027303
SGTC_1694 st024011 44.9 µM -1.37440650509103 0.0748315931520663 no 3080 0.0846577588846626 4453 2787533
SGTC_2480 5767542 37.17 µM -1.37499396576467 0.0747454743402595 no 3081 0.0845666577357049 4346 2867358
SGTC_2682 pyrogallin 40.03 µM -1.3760727722268 0.0745875236612273 no 3082 0.084399552115837 4425 822798 An ATP competetive kinase inhibitor.
SGTC_1313 1220-0047 237 µM -1.37818463404676 0.0742790584957386 no 3083 0.0840731451000122 4400 3528706
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.38072779052719 0.0739088911479147 no 3084 0.0836813365660794 4426 61125 An anti-inflammatory.
SGTC_445 e6 berbamine 66 µM -1.38145096206067 0.0738038882682163 no 3085 0.0835701728537785 4424 6610268 A calcium/calmodulin antagonist.
SGTC_2817 7995342 71.43 µM -1.38403221464504 0.073430025841048 no 3086 0.0831742954298463 4416 18879975
SGTC_929 2805-0021 398 µM -1.38698092835547 0.0730047155380749 no 3087 0.0827237892052617 4469 3098024
SGTC_2899 9053889 58.44 µM -1.3870246817771 0.0729984189508318 no 3088 0.0827171183845687 4405 6470052
SGTC_99 0109-0120 622.8 µM -1.39049838049928 0.0724998416940095 no 3089 0.0821887953746076 4438 759414
SGTC_2621 lithochol-11-enic acid 100 µM -1.39308821054975 0.0721298259378622 no 3090 0.081796558874328 4390 6708711
SGTC_2751 anetholtrithion 17.25 µM -1.39332182805565 0.0720965197054157 no 3091 0.0817612463907509 4395 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_898 1000-0849 28.3 µM -1.39345020852398 0.0720782218603624 no 3092 0.0817418459180208 4448 6751807
SGTC_1870 st057514 26.5 µM -1.39357935509052 0.0720598184168585 no 3093 0.0817223331762172 4444 5393161
SGTC_1468 k284-1086 134 µM -1.40258874530341 0.0707848466590609 no 3094 0.0803697549340388 4436 15996457
SGTC_2344 7990960 76.95 µM -1.40735083110485 0.0701179748895347 no 3095 0.0796616917172137 4420 140813
SGTC_275 trichlorophene 5.69 µM -1.40807689377539 0.0700167247088469 no 3096 0.0795541510943542 4473 62616
SGTC_310 1273-0058 1.06 µM -1.41373094212339 0.0692321065924941 no 3097 0.0787204583329885 4191 2734232
SGTC_1569 carminic acid 40.6 µM -1.41416189350288 0.0691725819857659 no 3098 0.0786571868631924 4526 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3000 9075062 71.4286 µM -1.41514907707576 0.0690363771528794 no 3099 0.0785123957001579 4423 17057871
SGTC_2191 5911152 200 µM -1.4164923946814 0.0688513675002142 no 3100 0.0783156946582154 4466 2875902
SGTC_1425 4048-4433 7.33 µM -1.41795318115043 0.0686506134326331 no 3101 0.0781022171267153 4506 23734946
SGTC_3253 9135987 49.47 µM -1.41921404453264 0.0684776977963139 no 3102 0.0779183113046805 4449 4182430
SGTC_252 miconazole 1.30953 nM -1.42188222164749 0.0681128902450496 no 3103 0.0775302225513159 4354 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1006 4099-6547 255 µM -1.42220948785085 0.0680682481335095 no 3104 0.077482722623939 4453 3146833
SGTC_2301 7769476 200 µM -1.42523468498481 0.0676566523102261 no 3105 0.0770446866210709 4430 977820
SGTC_363 0455-0021 3.06 µM -1.42932043660749 0.0671038171885112 no 3106 0.07645607736778 4405 4597466
SGTC_2470 5664817 21.68 µM -1.42940285249377 0.0670927017066899 no 3107 0.0764442395142349 4501 2859561
SGTC_326 k292-0812 17.5 µM -1.43030250847861 0.066971457133631 no 3108 0.0763151075823834 4431 3579357
SGTC_782 0083-0095 30.5 µM -1.43302627895336 0.0666054139926693 no 3109 0.0759251637432627 4412 3591729 An indicator and reagent.
SGTC_2270 7924575 90.91 µM -1.43369411061582 0.0665159019837044 no 3110 0.0758297867964232 4424 1262135
SGTC_81 0411-0046 9.971 µM -1.4353864301523 0.0662894909692084 no 3111 0.0755885053515808 4447 12925265
SGTC_3227 9130768 49.47 µM -1.43924200705498 0.0657758925246983 no 3112 0.0750409837199209 4545 17720899
SGTC_3188 9110789 49.47 µM -1.44084520612985 0.0655632417176181 no 3113 0.0748142094490734 4433 849217
SGTC_51 1013-0126 23.419 µM -1.4444695595717 0.0650844669773866 no 3114 0.0743034682066912 4455 1627850
SGTC_2196 6573537 42.6665 µM -1.44483671680632 0.0650361174963259 no 3115 0.0742518775638082 4486 2903087
SGTC_1035 k081-0041 55.2 µM -1.45108036330807 0.0642181775531163 no 3116 0.0733787418967249 4478 731709
SGTC_2145 5634607 200 µM -1.45239142901354 0.0640474433951532 no 3117 0.0731963990677056 4457 308662
SGTC_1691 st019933 84.6 µM -1.4560696188352 0.0635703331196003 no 3118 0.0726866875568357 4449 6176082
SGTC_1749 st037932 54.2 µM -1.45707837769085 0.0634399680933271 no 3119 0.0725473731070904 4478 594497
SGTC_952 1185-0122 232 µM -1.45958479064578 0.0631169574018926 no 3120 0.0722021108943107 4419 678600
SGTC_2264 7948757 110.76 µM -1.4631453654709 0.062660296897812 no 3121 0.0717138033605419 4453 2971411
SGTC_3089 9117425 49.47 µM -1.46368512497872 0.0625912955435712 no 3122 0.0716400008259453 4453 9401657
SGTC_100 0086-0128 49.5915 µM -1.46713692897198 0.0621514261785186 no 3123 0.0711694050184462 4479 93297
SGTC_2305 7443522 69.23 µM -1.4683736349914 0.0619944186711826 no 3124 0.0710013795703792 4369 5415886
SGTC_2159 5658611 73.75 µM -1.4709781405782 0.0616647729343021 no 3125 0.0706485142945117 4463 793844
SGTC_2428 5615643 7.78 µM -1.47230384392744 0.0614975084136712 no 3126 0.0704694228794194 4458 2253075
SGTC_1062 mesoridazine 14.2 µM -1.47470894214055 0.0611949610282722 no 3127 0.070145405477919 4526 4078 A neuroleptic.
SGTC_2472 5377652 49.4 µM -1.47572314105197 0.0610677298740281 no 3128 0.0700091155196099 4526 1610903
SGTC_380 3970-0968 6 µM -1.47814557745286 0.0607646721923874 no 3129 0.0696844085009223 4378 2891601
SGTC_3022 9087993 49.47 µM -1.4817866340336 0.0603113737124709 no 3130 0.0691985383178638 4558 17173644
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.48339701201396 0.0601117334939821 no 3131 0.0689844804176364 4462 2333 A French combination drug.
SGTC_2458 5808907 16.39 µM -1.48370352282874 0.0600737937110084 no 3132 0.0689437956479577 4596 2731747
SGTC_1634 st006576 41 µM -1.48388359362422 0.060051513366588 no 3133 0.0689199025437963 4468 3915356
SGTC_1822 st052468 42 µM -1.49267369296199 0.0589717517931756 no 3134 0.0677613114054243 4514 2873678
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.49332929101628 0.0588918335496806 no 3135 0.0676755059454708 4512 23665772 A membrane-active detergent.
SGTC_623 k072-0108 16.9 µM -1.50012195132444 0.0580687929021824 no 3136 0.0667914078711304 4463 5382803
SGTC_1 0258-0098 57.368 µM -1.50016768643363 0.0580632821472902 no 3137 0.0667854856564255 4402 6790032 YDR047W HEM12
SGTC_3025 9087895 49.47 µM -1.50095040156755 0.0579690342361316 no 3138 0.0666841952610954 4466 17173641
SGTC_3051 9093778 49.47 µM -1.50231589350578 0.0578049011886318 no 3139 0.0665077729622278 4590 17217378
SGTC_1786 berberine 21.6 µM -1.5052302956022 0.057455810304502 no 3140 0.0661324394043594 4402 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1191 1487-1166 10.6 µM -1.50564755370678 0.0574059665922363 no 3141 0.066078837034322 4517 3955771
SGTC_188 3229-0966 278.469 µM -1.50756061548132 0.057177876543124 no 3142 0.0658335095503016 4550 5722370
SGTC_2370 9071495 200 µM -1.50833022947109 0.0570863186447146 no 3143 0.0657350150337785 4506 21791103
SGTC_2549 cedrol 20.94 µM -1.5101475089418 0.0568705821855511 no 3144 0.0655028945587262 4439 6708665 A sedative which affects the nervous system.
SGTC_897 1000-0139 31.4 µM -1.51084205918637 0.0567882991554922 no 3145 0.065414347977757 4465 6151020
SGTC_534 k292-0788 63.4 µM -1.51465787038359 0.0563379133455535 no 3146 0.0649295343350767 4556 4146317
SGTC_1751 st044839 27.194 µM -1.51745230130281 0.0560098722076856 no 3147 0.0645762638056467 4552 5291326
SGTC_2162 5663267 200 µM -1.51811496395037 0.0559323029734499 no 3148 0.0644927097373852 4509 6456493
SGTC_2992 9074591 71.4286 µM -1.5195698836214 0.0557622918816076 no 3149 0.0643095559080707 4446 17741321
SGTC_686 1319-0111 510 µM -1.51991415036071 0.055722123150931 no 3150 0.0642662767865812 4515 4562600
SGTC_980 1473-0395 201 µM -1.52649185616327 0.0549590200357916 no 3151 0.0634437085402834 4423 768876
SGTC_98 0074-0023 107.663 µM -1.52761657725556 0.0548293678141194 no 3152 0.0633038817264837 4499 3563821
SGTC_1903 st060211 78.3 µM -1.53034157482814 0.0545162461101289 no 3153 0.0629661012557783 4539 688960
SGTC_2247 cerulenin 830 nM -1.53182137071903 0.0543468004596102 no 3154 0.062783260461605 4531 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1235 benzylparaben 21.5 µM -1.54203373759281 0.0531887553977644 no 3155 0.0615326977027294 4545 7180
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.54434579584722 0.0529293117685899 no 3156 0.0612522918935407 4539 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1049 3226-0134 66 µM -1.5493935738713 0.0523663721879588 no 3157 0.0606435688055778 4545 5702385
SGTC_2484 5809818 12.04 µM -1.55163759221878 0.0521176454270917 no 3158 0.0603744814906843 4498 2870548
SGTC_1777 st045864 34.765 µM -1.55366739140592 0.05189347185952 no 3159 0.0601318875612249 4535 4691462
SGTC_323 4013-0906 34.3 µM -1.55387779805507 0.0518702781822834 no 3160 0.0601067842712024 4544 2910086
SGTC_677 0929-0063 136 µM -1.56272686229652 0.0509022596004375 no 3161 0.0590584266504632 4558 1539583
SGTC_155 k072-0202 43.6 µM -1.56601150649168 0.0505466263475745 no 3162 0.0586729617043427 4509 5857737
SGTC_879 0831-1030 162 µM -1.5674442912961 0.0503921179342777 no 3163 0.0585054390349424 4530 1549252
SGTC_3170 9103054 49.47 µM -1.56797798632042 0.0503346617088328 no 3164 0.0584431349534585 4500 16432970
SGTC_1643 st009866 20.2 µM -1.57072418932064 0.0500398376225814 no 3165 0.0581233639845305 4503 3156273 YOR207C RET1
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.57106954114961 0.0500028593571153 no 3166 0.0580832483284132 4502 97141
SGTC_292 k038-0015 474 µM -1.57270408268712 0.0498281376918148 no 3167 0.0578936770307729 4510 46368540
SGTC_2251 lansoprazole 556 µM -1.57668979237663 0.0494041330095854 no 3168 0.0574334601357605 4508 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1240 0356-0016 42.1 µM -1.58793444194271 0.0482234248512671 no 3169 0.0561505821347795 4507 4305613
SGTC_3255 9139072 49.47 µM -1.58836565013134 0.0481786006423363 no 3170 0.0561018400800647 4537 17646060
SGTC_638 3970-0837 4.09 µM -1.58936978202802 0.0480743500539061 no 3171 0.0559884663299462 4521 4118451 YLR208W SEC13
SGTC_2304 7443016 91.4 µM -1.58967006904222 0.0480432088629909 no 3172 0.0559545968806621 4482 939854
SGTC_2922 7999257 32.47 µM -1.59372043681839 0.047624741978992 no 3173 0.0554993323705975 4503 2988377
SGTC_2356 9061756 188.97 µM -1.59570170255532 0.0474211119204018 no 3174 0.0552777041708801 4577 20104043
SGTC_1384 3089-0840 101 µM -1.61152121378482 0.0458201332420962 no 3175 0.0535330836498346 4536 1069836
SGTC_1348 1493-0373 93.8 µM -1.61220728448067 0.0457516959818902 no 3176 0.053458420325642 4568 3010129
SGTC_2792 7535235 81.82 µM -1.62172562448795 0.0448106687715065 no 3177 0.0524310548150725 4520 1281891
SGTC_1068 loratadine 26.9 µM -1.62648904463228 0.0443456203675693 no 3178 0.0519228310134277 4587 3957 A H1 histamine antagonist.
SGTC_464 bw-b 70c 158 µM -1.62955361451453 0.0440484907659047 no 3179 0.0515979373646203 4553 5353454
SGTC_398 bronopol 33.3 µM -1.62995591070368 0.0440096050608935 no 3180 0.0515554077864384 4483 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_86 0417-1630 471.922 µM -1.6302553027456 0.043980683978388 no 3181 0.0515237750287299 4561 3634867
SGTC_3325 9138760 55.175 µM -1.63335511138211 0.0436821444138659 no 3182 0.0511971660492314 4505 43844959
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.63628835086398 0.0434011547661644 no 3183 0.050889626487004 4549 5377381
SGTC_2715 st079500 56.4 µM -1.63887696663503 0.0431543921622198 no 3184 0.050619442809515 4559 28246688
SGTC_1326 1431-2094 10.8 µM -1.64123033292373 0.042931039558359 no 3185 0.0503748057028813 4575 616278
SGTC_381 3461-2219 42.7 µM -1.64716676675046 0.042371774608648 no 3186 0.0497618863299832 4549 2883159
SGTC_774 k060-0086 136 µM -1.64873510638404 0.0422250113688611 no 3187 0.0496009573292517 4576 5911235
SGTC_2355 9061122 103.12 µM -1.66228299100832 0.0409742708320343 no 3188 0.0482280232783984 4571 5302957
SGTC_2583 asiatic acid 100 µM -1.66265088296067 0.0409407307301578 no 3189 0.0481911697042482 4569 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2731 amoxapine 43.43 µM -1.66319754432611 0.0408909336510537 no 3190 0.0481364495247645 4716 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_338 4055-0136 114 µM -1.66828457172056 0.04042989283026 no 3191 0.0476296245765663 4557 2900563
SGTC_719 2810-4230 27.3 µM -1.67549514556533 0.0397836339282378 no 3192 0.046918561370439 4599 721079
SGTC_2706 st078239 82.5 µM -1.67575183801929 0.0397607831816534 no 3193 0.0468934057054377 4555 15434492
SGTC_1632 st005650 90 µM -1.67674144244091 0.0396727885034195 no 3194 0.0467965264483959 4596 2759605
SGTC_993 3909-8757 62.7 µM -1.67909135692532 0.0394644707337137 no 3195 0.0465671202144809 4543 4288324 YLR208W SEC13
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.68096506136547 0.0392990069130719 no 3196 0.0463848505841745 4598 5024745
SGTC_3027 9089541 49.47 µM -1.68504083135094 0.0389410315727851 no 3197 0.045990346995201 4575 9943819
SGTC_108 0509-0257 621.132 µM -1.68507288234143 0.0389382270886296 no 3198 0.0459872554184102 4555 536624
SGTC_2735 sertaconazole 140 nM -1.69078367908134 0.0384411476775852 no 3199 0.0454390627191407 4700 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_389 tpck 16.7 µM -1.69157413942235 0.0383727537147107 no 3200 0.045363600362108 4610 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1974 st069448 26.9 µM -1.69275348350175 0.0382708963325748 no 3201 0.0452512001201212 4575 6323587 YNR016C ACC1
SGTC_3324 9138759 60.749 µM -1.69660576672344 0.0379397182227418 no 3202 0.0448856094190711 4592 45595710
SGTC_888 0916-0002 6.97 µM -1.697034965153 0.0379029655438692 no 3203 0.0448450251246099 4583 2802138 YIL048W NEO1
SGTC_160 3453-0671 289.699 µM -1.69831340189686 0.0377936638745375 no 3204 0.0447243132994346 4575 5322268
SGTC_876 0720-0963 56.8 µM -1.69951853287298 0.0376908652570811 no 3205 0.0446107628322698 4594 765861
SGTC_1555 citronellol 128 µM -1.70077601382954 0.0375838446014244 no 3206 0.0444925275006965 4570 8842 A terpine precursor.
SGTC_2871 9038510 12.99 µM -1.70402158949171 0.0373087690643101 no 3207 0.0441885269620982 4542 4945164
SGTC_2688 kanamycin b 96.69 µM -1.70868551102575 0.0369163650667303 no 3208 0.0437546096962286 4545 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1274 0865-0114 173 µM -1.71215034106927 0.0366270377400076 no 3209 0.0434344830938369 4589 870624
SGTC_90 0870-0863 4.608 µM -1.71594562471958 0.0363122477162941 no 3210 0.0430859975262908 4617 1738164
SGTC_1058 3448-5425 97.3 µM -1.72025284175452 0.0359576830880299 no 3211 0.0426932457644776 4544 7279705
SGTC_585 0kpi-0023 191 µM -1.72036171965356 0.0359487572787449 no 3212 0.04268335541027 4534 64601
SGTC_2088 5278280 127.392 µM -1.72074299482117 0.0359175146488907 no 3213 0.0426487353735353 4619 791502
SGTC_1616 st002734 56.1 µM -1.73514105670741 0.0347538862436719 no 3214 0.0413579118524154 4589 4026101
SGTC_1659 st012954 42.1 µM -1.73624938919376 0.0346656107248552 no 3215 0.0412598739153618 4597 24207262
SGTC_29 0299-0004 12.984 µM -1.73654948082331 0.0346417409885283 no 3216 0.0412333616403099 4536 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3003 9075612 71.4286 µM -1.74175081355337 0.0342301595289081 no 3217 0.0407760284084213 4614 6501993
SGTC_171 k064-0041 9.68 µM -1.75164383334644 0.0334584189184816 no 3218 0.0399175351937023 4586 53325
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.75241432867113 0.0333989197920026 no 3219 0.0398512946873339 4578 688761
SGTC_775 4577-0580 57.3 µM -1.75311033125862 0.0333452480574435 no 3220 0.0397915352578537 4606 2006902
SGTC_2895 9054447 58.44 µM -1.76833882650344 0.0321885818078467 no 3221 0.0385021383466132 4675 2697450
SGTC_698 k064-0052 127 µM -1.77224483684476 0.0318973013444888 no 3222 0.0381769618837356 4687 5088751
SGTC_619 1652-1634 108 µM -1.78164587408907 0.0312051610342636 no 3223 0.0374034992808172 4614 5400454
SGTC_962 1254-0300 21.5 µM -1.78191638795923 0.0311854301099506 no 3224 0.0373814338350063 4607 7340576
SGTC_489 paxilline 115 µM -1.78341714867188 0.0310761539584549 no 3225 0.0372592118833093 4582 105008 A toxic potassium channel blocker.
SGTC_2560 caryophyllene 100 µM -1.78415534272719 0.0310225195668333 no 3226 0.0371992132629002 4647 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3236 9132701 49.47 µM -1.78952990437144 0.0306343289450093 no 3227 0.0367647579377416 4637 24282524
SGTC_343 4130-2827 29.8 µM -1.79919297855757 0.0299465099429765 no 3228 0.0359940798760998 4619 1118244
SGTC_787 4152-0075 138 µM -1.80020112718069 0.0298754934420924 no 3229 0.0359144429642646 4662 9566539
SGTC_630 4356-0227 183 µM -1.80064090885383 0.0298445579147471 no 3230 0.0358797484366057 4582 779312
SGTC_2433 5607874 27.82 µM -1.80198915145238 0.0297498841537085 no 3231 0.0357735562044691 4586 2252428
SGTC_2427 5545055 42.75 µM -1.81116561632943 0.0291121105550804 no 3232 0.0350576094441137 4574 5372858
SGTC_1622 st003707 19.4 µM -1.81245412651491 0.0290234740092472 no 3233 0.0349580279789455 4634 10140899
SGTC_1766 st045414 44.774 µM -1.81704196766359 0.028709695522706 no 3234 0.0346053437590831 4632 253960
SGTC_3293 9120939 62.045 µM -1.82172432571809 0.0283923665016997 no 3235 0.0342484125113863 4624 934087
SGTC_1674 st016616 23.6 µM -1.82293957580166 0.0283104862647962 no 3236 0.0341562715212981 4606 625830
SGTC_1675 st018485 24.5 µM -1.8249647117972 0.028174474786835 no 3237 0.0340031773411488 4620 3323024
SGTC_123 0083-0120 66.675 µM -1.84220295423831 0.0270386064993132 no 3238 0.0327227342425846 4618 16001701
SGTC_132 0417-1715 25.805 µM -1.8528133741965 0.0263586520786582 no 3239 0.0319545563088409 4617 6769098
SGTC_1985 st071382 65.5 µM -1.85699831412947 0.0260944248251976 no 3240 0.0316556969675079 4648 6123237
SGTC_25 0118-0223 35.662 µM -1.86293600676656 0.0257233369355923 no 3241 0.0312356350795242 4635 5333628
SGTC_2250 alverine citrate 130 µM -1.87230518287415 0.0251467810741702 no 3242 0.0305821970720257 4517 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2004 4023728 41.89 µM -1.87359616082104 0.0250681930224802 no 3243 0.0304930538029924 4597 360084 YDR527W RBA50
SGTC_1883 5-benzylidenerhodanine 20 µM -1.89429509511085 0.0238360037054982 no 3244 0.0290929258533915 4644 1273210
SGTC_3037 9091026 49.47 µM -1.90609462350091 0.023156656971516 no 3245 0.0283189650713535 4541 25236398 YIL048W NEO1
SGTC_2071 5230951 39.92 µM -1.91355582069383 0.0227355556308987 no 3246 0.0278384673048546 4689 1799272
SGTC_328 k915-0120 63.5 µM -1.91395507984064 0.0227132050092763 no 3247 0.0278129478213461 4680 6624543
SGTC_2487 5918373 44.05 µM -1.91481068652173 0.0226653703037086 no 3248 0.0277583255651565 4683 2876279
SGTC_1957 st077035 62.4 µM -1.91751467314425 0.0225147554459138 no 3249 0.0275862893405561 4675 705593
SGTC_2708 st078559 56 µM -1.9328186526805 0.021678125412715 no 3250 0.0266292708522931 4644 17250902
SGTC_1984 st072354 53.1 µM -1.93971730979503 0.021309670109081 no 3251 0.0262070273694451 4590 5762938
SGTC_2930 9013230 14.89 µM -1.94034357410397 0.0212764852752578 no 3252 0.026168974558567 4617 2995857
SGTC_2023 5144124 124 µM -1.95779193068303 0.0203693410136217 no 3253 0.0251272163365825 4648 2830192
SGTC_1244 0416-0015 52.5 µM -1.95899254135773 0.0203081449495969 no 3254 0.0250568301406133 4643 96201
SGTC_2386 9075165 157.42 µM -1.95965027788875 0.0202746857319101 no 3255 0.025018340244539 4670 16452277
SGTC_134 0269-0018 6.916 µM -1.96180979407101 0.0201651590464063 no 3256 0.0248923164961577 4635 4378915
SGTC_2757 clomiphene 4.22 µM -1.96292873835458 0.0201086058646702 no 3257 0.0248272274702061 4658 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2575 plumbagin 510 nM -1.96702232932672 0.0199028542941641 no 3258 0.0245903182827659 4618 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_341 1486-1430 230 µM -1.9676883697389 0.019869547400891 no 3259 0.0245519524100976 4649 2054753 YPL210C SRP72
SGTC_1939 st074455 53.6 µM -1.97469044823749 0.0195222456456592 no 3260 0.0241516437775515 4623 1644229
SGTC_1596 piperlongumine 63 µM -1.98295204975422 0.0191191153235964 no 3261 0.023686392925425 4688 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1148 3909-7663 27.7 µM -1.98395325250446 0.0190707452220569 no 3262 0.0236305257678658 4687 4084526
SGTC_2944 9067346 25.62 µM -1.98480621341929 0.0190296191025687 no 3263 0.0235830179720902 4593 6473075
SGTC_3211 9128781 49.47 µM -1.98721369224131 0.0189139474312669 no 3264 0.023449360578925 4582 17194361
SGTC_1958 st076513 41.9 µM -1.990201082008 0.0187712449357391 no 3265 0.0232843945896274 4625 732122 YGL099W LSG1
SGTC_162 k030-0015 37.8 µM -1.99362534733953 0.0186088016068711 no 3266 0.0230965065943905 4703 1809920 YMR134W ERG29
SGTC_2019 4016004 108 µM -1.99554779903263 0.0185181282912195 no 3267 0.0229915831796704 4666 45595336
SGTC_2857 9024691 58.44 µM -1.99824174946394 0.0183917000358551 no 3268 0.022845228650872 4674 16478292
SGTC_1116 jasmonic acid 1.58368 µM -2.01130061744146 0.0177892124018213 no 3269 0.0221468566659526 4721 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_975 1335-0046 28.5 µM -2.03608796382634 0.0166918471579326 no 3270 0.0208707615676828 4692 16486740
SGTC_2017 5132927 60.65 µM -2.04056491050059 0.0164999506760802 no 3271 0.020647046479093 4652 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2824 7998404 51.95 µM -2.0451860309853 0.016303858236747 no 3272 0.0204182605681147 4668 837851
SGTC_1891 st059073 26.2 µM -2.04771128555471 0.0161975475174873 no 3273 0.0202941486884009 4722 688754
SGTC_994 3910-0338 138 µM -2.05008371432186 0.0160982122244907 no 3274 0.020178131165429 4704 3479481
SGTC_2111 5486399 200 µM -2.0543878261807 0.0159193283458653 no 3275 0.0199690851894539 4657 689674
SGTC_3139 9095020 49.47 µM -2.07004848626647 0.0152827628520925 no 3276 0.0192239020866723 4622 25236292
SGTC_395 anisomycin 6.25 µM -2.0726563613091 0.0151789113096277 no 3277 0.0191021358667495 4704 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1052 3253-3998 198 µM -2.07560886351359 0.01506206823554 no 3278 0.0189650705037903 4669 5450317
SGTC_1684 st024538 14.6195 µM -2.09729638663851 0.0142272572604302 no 3279 0.0179836732690498 4711 6732859
SGTC_2897 9048598 12.99 µM -2.10891409266833 0.0137966820517717 no 3280 0.0174759987722762 4688 6467404
SGTC_3335 9143315 29.6265 µM -2.11504156663328 0.013574146981468 no 3281 0.0172132023768734 4704 4899691
SGTC_2188 6126565 140.678 µM -2.12033527627644 0.0133843932990716 no 3282 0.0169888903756668 4670 874518
SGTC_1204 4049-0315 18.3 µM -2.12686463735563 0.0131535062517527 no 3283 0.0167156659071127 4688 588402
SGTC_3113 9123498 49.47 µM -2.13030520740018 0.0130332335627849 no 3284 0.0165732119599452 4761 8897275
SGTC_3120 9124077 49.47 µM -2.13135776537738 0.0129966295057527 no 3285 0.0165298397519244 4773 18774327 YGL155W CDC43
SGTC_1624 st003710 6.25 µM -2.13509064367583 0.0128675294945713 no 3286 0.0163768033748562 4723 24207033
SGTC_2080 5212524 12.4 µM -2.14591368585734 0.0124994700283387 no 3287 0.0159399328518028 4680 260183
SGTC_1057 3448-5381 134 µM -2.14707366159226 0.012460568892995 no 3288 0.0158937088820626 4702 5497911
SGTC_122 0236-0016 402.397 µM -2.16592709790825 0.0118428421011121 no 3289 0.0151583791151735 4698 6808838
SGTC_400 oxethazaine 37.5 µM -2.16846835875075 0.0117616449933386 no 3290 0.0150615347607471 4736 4621 A local anesthetic.
SGTC_1514 1189-1591 158 µM -2.17721383820627 0.0114858948997676 no 3291 0.0147323081440597 4718 767698 YMR146C TIF34
SGTC_2425 5628681 7.85 µM -2.19117417806412 0.0110573511012821 no 3292 0.0142195952259664 4728 5714958
SGTC_1265 0819-1001 68.8 µM -2.19224307499397 0.0110251196656681 no 3293 0.0141809798404683 4677 3106768
SGTC_2643 anethole 100 µM -2.21944299605184 0.0102319895395688 no 3294 0.0132283006387565 4730 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_130 0136-0219 337.655 µM -2.22410408106118 0.0101011907881113 no 3295 0.013070721194924 4670 234244
SGTC_1850 st056238 17 µM -2.24052902091523 0.00965183488193158 no 3296 0.0125282994478528 4736 5393177
SGTC_1078 idebenone 36.1 µM -2.25605258839679 0.00924329682856852 no 3297 0.0120336689378169 4753 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_450 aminopyrene 156 nM -2.25678167873641 0.00922448691423308 no 3298 0.012010860054846 4715 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2507 purpurin 79.67 µM -2.26557401162428 0.00900027666018114 no 3299 0.0117387388838194 4709 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2793 7325131 81.82 µM -2.26892334049409 0.00891613052850487 no 3300 0.0116364940376003 4708 4176441
SGTC_1412 3909-8563 178 µM -2.27436586789544 0.00878086610923328 no 3301 0.011471998930536 4768 23767530
SGTC_701 4424-0219 185 µM -2.27528102721218 0.00875829898303633 no 3302 0.0114445384219682 4745 2911779
SGTC_63 0099-0242 26.702 µM -2.27644529689225 0.0087296624887472 no 3303 0.0114096855890769 4725 3898502 YLR359W ADE13
SGTC_2047 4141938 200 µM -2.28962469492884 0.00841118105540404 no 3304 0.0110215410901901 4747 3807862
SGTC_3286 9117135 37.221 µM -2.32271047569679 0.00765619761941303 no 3305 0.0100973555670721 4698 3438150
SGTC_3201 9113999 49.47 µM -2.32648940605255 0.0075738822081744 no 3306 0.00999622848963412 4709 16649224
SGTC_165 k038-0023 64.381 µM -2.3280360781922 0.00754041688468638 no 3307 0.0099550940027477 4714 46368543
SGTC_1130 3454-2858 15.9 µM -2.3568250768058 0.00694084746480835 no 3308 0.00921596349795072 4710 715628 YIL048W NEO1
SGTC_118 0083-0097 135.343 µM -2.3578997235346 0.00691930534544819 no 3309 0.00918932838967856 4708 5207356
SGTC_129 0088-0017 176.636 µM -2.3777704038175 0.00653148288226771 no 3310 0.00870883360281462 4647 182446
SGTC_1686 st019653 115.5 µM -2.38651129351527 0.00636706135882074 no 3311 0.00850454247038969 4768 97252
SGTC_971 1315-0384 26.7 µM -2.46812604109526 0.00500010169857275 no 3312 0.00679112428765604 4764 6769120
SGTC_1796 st049173 110.4 µM -2.49659644948135 0.00458875669483796 no 3313 0.00626957820072702 4758 94134
SGTC_1523 st012844 44.7 µM -2.50570250244807 0.00446371891317247 no 3314 0.00611041980477383 4764 4274103
SGTC_78 0336-0123 156.75 µM -2.53324677689657 0.00410381754413705 no 3315 0.00565056801289324 4710 6765896
SGTC_2203 7227154 166.4 µM -2.53631183262001 0.00406541913288261 no 3316 0.00560134646183376 4777 896304
SGTC_647 0140-0236 81 µM -2.53723217770821 0.00405395218028091 no 3317 0.00558664121656559 4775 990837
SGTC_3254 9136651 49.47 µM -2.56062292059309 0.00377206933101018 no 3318 0.00522423469484047 4746 16454030
SGTC_1841 st054148 70 µM -2.56509691483341 0.00372020003576461 no 3319 0.0051573495102458 4764 675442
SGTC_451 chloral hydrate 100 µM -2.56847570425145 0.00368145296079776 no 3320 0.00510734361468937 4756 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1262 0737-0114 49.6 µM -2.56977698475988 0.00366662704531187 no 3321 0.00508820016048767 4770 765919
SGTC_1512 0259-0544 12.2 µM -2.57379304739782 0.00362120790982837 no 3322 0.00502952107235395 4748 18476
SGTC_2833 9001315 45.46 µM -2.59156945995606 0.00342617289916673 no 3323 0.00477696264584234 4723 2989378
SGTC_237 nikkomycin 200 µM -2.59788559029452 0.00335918122328016 no 3324 0.00468998705256574 4780 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2098 5376439 882.5 nM -2.60530075433201 0.00328203692023918 no 3325 0.00458968225343126 4783 2844116
SGTC_1783 st039459 87.517 µM -2.6200807590142 0.00313300737421774 no 3326 0.00439544730286759 4778 729761
SGTC_1253 0550-0034 176 µM -2.6660543330405 0.00270759171293442 no 3327 0.00383736441297193 4755 5969915
SGTC_3292 9120825 59.784 µM -2.66720494226255 0.00269764801541845 no 3328 0.00382425078711897 4764 24824900
SGTC_2383 9036125 200 µM -2.67616579883708 0.00262132862169342 no 3329 0.0037234897500527 4771 79580
SGTC_3121 9125696 49.47 µM -2.69276420166295 0.00248509455253517 no 3330 0.0035431183072281 4792 1235365
SGTC_34 0469-0683 81.75 µM -2.69329114103727 0.00248087643648663 no 3331 0.00353752288937379 4780 3690923
SGTC_2892 9047358 58.44 µM -2.69567992255842 0.00246183548694715 no 3332 0.00351225648795874 4778 6466771
SGTC_1605 st000082 49.1 µM -2.75536671470166 0.00202699010427968 no 3333 0.00293131927147264 4776 1114022
SGTC_1203 3992-3522 103 µM -2.77142596493579 0.00192255144651379 no 3334 0.00279056812484814 4751 5322312
SGTC_2818 7996756 12.99 µM -2.85667494101998 0.00144561508994653 no 3335 0.00214052008091443 4780 2241621
SGTC_3034 9090421 49.47 µM -2.86956161054724 0.001383757951678 no 3336 0.00205520622970779 4764 17173761
SGTC_2841 9004761 38.96 µM -2.91052042768971 0.00120285981527041 no 3337 0.00180413689403383 4749 2991039
SGTC_1756 st041558 35.5 µM -2.9835361128685 0.000933118848737063 yes 3338 0.00142469204232409 4798 3955792
SGTC_3257 9139206 32.98 µM -3.0252687813129 0.000805123089192661 yes 3339 0.00124206130474372 4796 4910041
SGTC_71 0417-1750 47.813 µM -3.03760820786844 0.000770497253796295 yes 3340 0.00119231886060812 4764 6811472
SGTC_1677 st019204 53.9 µM -3.12735293194421 0.000557079108276082 yes 3341 0.000881940218094453 4786 3945625
SGTC_2679 rapamycin 1 nM -3.13015572066677 0.000551392812293486 yes 3342 0.000873568302695541 4699 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_119 0121-0043 24.815 µM -3.34730803778617 0.000243080389336168 yes 3343 0.000408002404943895 4800 1092378
SGTC_983 1491-0821 12.2 µM -3.36875162078016 0.000223613266758466 yes 3344 0.000377547200559965 4797 46495113
SGTC_1720 st037298 9.481 µM -3.49841996008578 0.000133645454827785 yes 3345 0.000234011771669492 4790 597396
SGTC_3328 9140624 29.0385 µM -3.60278249627823 8.7223246727274e-05 yes 3346 0.000157414476627729 4801 4904392
SGTC_696 1560-0013 611 µM -3.60801900144106 8.53505404274311e-05 yes 3347 0.00015427194886137 4807 1650269
SGTC_984 1492-0255 2.91 µM -3.67150640231391 6.54571629192397e-05 yes 3348 0.000120562518368991 4802 1585198
SGTC_2813 7971799 71.43 µM -3.71637517762975 5.41285533060398e-05 yes 3349 0.000101050707249028 4790 2234054
SGTC_170 4197-0004 226 µM -3.85700415198377 2.94408523094741e-05 yes 3350 5.73926066793885e-05 4795 218692
SGTC_3104 9120930 49.47 µM -4.05625294644494 1.19983119672048e-05 yes 3351 2.49331275230017e-05 4806 17014836
SGTC_58 0957-0393 9 µM -4.43569129301244 1.93887072306533e-06 yes 3352 4.58886455699179e-06 4659 6997992
SGTC_2842 9000675 19.48 µM -7.8286497331651 1.99015190717663e-16 yes 3353 2.46568699262158e-15 4810 2989072