SGTCid condition conc unit YLR118C|YLR118C.score YLR118C|YLR118C.strain.pval YLR118C|YLR118C.strain.significant YLR118C|YLR118C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1284 0929-0043 16 µM 4.0303521753592 4.45993296743983e-06 yes 1 2.78466728100144e-05 22 1239883
SGTC_279 1273-0055 2.93 µM 4.01333345778051 4.86621434422413e-06 yes 2 2.99336231349861e-05 39 2847562
SGTC_1523 st012844 44.7 µM 3.870913962675 9.96037050985644e-06 yes 3 5.42140295846239e-05 23 4274103
SGTC_1169 aniline yellow 25.8 µM 3.86958060285233 1.00262674401789e-05 yes 4 5.45113671225007e-05 10 6051 A DNA damaging agent.
SGTC_986 1493-0483 84 µM 3.63100056955953 3.15550986331419e-05 yes 5 0.00014116228071154 19 40079
SGTC_3202 9113761 49.47 µM 3.55749814448237 4.43279155385761e-05 yes 6 0.00018720187258535 61 4798415
SGTC_3212 9128307 49.47 µM 3.54358332185641 4.7240493489416e-05 yes 7 0.00019736427911556 65 27243542
SGTC_935 2996-0153 430 µM 3.43618506481568 7.66204821327804e-05 yes 8 0.000294983912122681 35 23738523
SGTC_3128 9127691 49.47 µM 3.38535053877211 9.58816770672119e-05 yes 9 0.00035543705229463 32 41316314
SGTC_1281 0884-0031 11.8 µM 3.33964117490306 0.000117003703687713 yes 10 0.000419433507951908 46 1548255
SGTC_1171 0368-0077 21.4 µM 3.21577466849224 0.000198263477864157 yes 11 0.000650464677554499 37 3239779
SGTC_503 tyrphostin 8 294 µM 3.12799349142924 0.000285046078709191 yes 12 0.000880020393648943 65 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_284 0988-0104 32.6 µM 3.12108393330297 0.00029319917878061 yes 13 0.000900933347807423 31 4666532
SGTC_559 1550-0661 158 µM 2.91736848105716 0.000657033204866134 yes 14 0.00176499240396432 50 5830875
SGTC_415 dibenzyl ketone 100 µM 2.89675679780202 0.000711041865628605 yes 15 0.00188520960359984 46 7593
SGTC_1115 galangin 695.678 nM 2.88011436501601 0.000757604887546774 yes 16 0.00198765470480019 68 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2395 5646831 180.19 µM 2.86132799904058 0.000813531654425258 yes 17 0.00210935173091137 79 6808628
SGTC_2612 dictamnine 15.46 µM 2.81819657035889 0.000956599227692338 yes 18 0.00241471167435303 111 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2504 purpurogallin 52.29 µM 2.78676583447537 0.00107503060965594 no 19 0.00266184665187724 74 5281571 An antioxidant.
SGTC_3133 9127736 49.47 µM 2.74597036942444 0.00124878666801309 no 20 0.00301661061788209 87 27243420
SGTC_1024 4507-0395 26 µM 2.71317180109171 0.0014067159281061 no 21 0.00333212729988608 99 4201836
SGTC_2608 thymoquinone 42.66 µM 2.70691339257093 0.00143884755357727 no 22 0.00339559858395064 83 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1270 0831-1170 17.3 µM 2.70330664597693 0.00145766807190953 no 23 0.00343266888756394 81 6764716
SGTC_290 2043-6722 48.1 µM 2.69544171510466 0.0014994899166629 no 24 0.00351476873946629 81 773758 YLR208W SEC13
SGTC_546 peri-Naphthalide 147 µM 2.67858624081377 0.00159282898802086 no 25 0.00369668451424946 76 223824 A penicillin ester.
SGTC_739 1486-1183 203 µM 2.67440370637049 0.00161679582921803 no 26 0.00374311359278614 74 4346692
SGTC_1015 4130-4525 82 µM 2.65983771321009 0.00170284926710343 no 27 0.00390891552992516 91 1363237
SGTC_182 3448-4371 550.524 µM 2.65829964054347 0.00171217518144801 no 28 0.0039268016383773 91 3491403
SGTC_217 ketoconazole 989 nM 2.50190541189623 0.00294230029085076 no 29 0.00617634613516244 112 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2282 7944268 200 µM 2.48375819147338 0.00312750072083402 no 30 0.00650020262982277 153 2970414
SGTC_3195 9113082 49.47 µM 2.48203636247088 0.00314560668922471 no 31 0.00653169719633164 98 17018038
SGTC_2797 7859098 81.82 µM 2.4615291772829 0.00336862030432445 no 32 0.00691730722446559 140 972681
SGTC_1032 k061-1018 98.7 µM 2.44959328778183 0.00350487022785147 no 33 0.00715088285049741 145 4005393
SGTC_3315 9136395 68.55 µM 2.44870702901515 0.00351518171609349 no 34 0.00716850052006057 110 16876844
SGTC_2687 chenodiol 100 µM 2.4485699704466 0.00351677880204406 no 35 0.00717122848138235 117 5702181 A cholesterol synthesis inhibitor.
SGTC_400 oxethazaine 37.5 µM 2.3852639431683 0.0043279984230415 no 36 0.00853343574239424 124 4621 A local anesthetic.
SGTC_3343 9148379 18.9835 µM 2.37776530306557 0.00443440728050697 no 37 0.00870895406245104 111 1955036
SGTC_1031 k035-0009 16 µM 2.37592014608092 0.00446094651723689 no 38 0.0087526253607601 164 5180959
SGTC_3307 9126885 69.2785 µM 2.37184002898097 0.00452013589077754 no 39 0.00884987607384761 160 24824909
SGTC_780 0109-0199 192 µM 2.36402555395996 0.00463545964796667 no 40 0.0090387828038973 153 610414
SGTC_2412 st077135 33.4 µM 2.34873917990611 0.00486866868814017 no 41 0.00941854831543476 162 13258915
SGTC_1480 1070-0044 41.2 µM 2.34254664213374 0.00496608027391776 no 42 0.00957631994236015 135 3124987
SGTC_1521 st012942 49.4 µM 2.30676873436208 0.00556362635263746 no 43 0.0105338580586135 173 24207259
SGTC_185 k048-0037 25.491 µM 2.2998666146305 0.00568598901102094 no 44 0.0107278890137025 107 6827589
SGTC_564 3555-0129 330 µM 2.28043571089933 0.00604339120127982 no 45 0.0112909298289124 83 563260
SGTC_2859 9028643 45.46 µM 2.25896890752103 0.00646126390732884 no 46 0.0119426595143235 111 17151580
SGTC_2983 9022671 12.99 µM 2.23506218615634 0.00695653746320427 no 47 0.0127066332253925 140 6405161
SGTC_281 1672-3440 14.9 µM 2.22887834313865 0.00708998282120348 no 48 0.0129110002228048 129 6833000
SGTC_609 0986-0026 86.3 µM 2.22636227536346 0.00714492199634778 no 49 0.0129949626115876 195 2848610
SGTC_1212 0520-0165 585 µM 2.2234055521275 0.00720996271853875 no 50 0.0130942328299303 182 5403258
SGTC_418 lividomycin a 100 µM 2.20636389780283 0.00759511288397344 no 51 0.0136792653500611 146 72394 An antibiotic.
SGTC_751 0833-0568 350 µM 2.20177371328836 0.00770190253662338 no 52 0.0138406483958076 163 6954252
SGTC_2670 beta-carotene 100 µM 2.19588979057631 0.00784072218881838 no 53 0.0140499163290897 82 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2995 9067767 71.4286 µM 2.19534310894787 0.00785373114934915 no 54 0.0140694973801904 144 11673567
SGTC_783 0848-0141 92.7 µM 2.18815787684392 0.00802648561747597 no 55 0.0143290521241211 161 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1976 st070609 63.5 µM 2.15419413278147 0.00888906795686012 no 56 0.0156124753987399 150 682556
SGTC_2186 6124449 200 µM 2.14978877548685 0.00900670083675533 no 57 0.0157859632264935 173 3834182 YLR033W RSC58
SGTC_2647 atorvastatin 60.16 µM 2.13118086381261 0.00951874574830431 no 58 0.0165371224431835 176 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_623 k072-0108 16.9 µM 2.12235840213973 0.009770288957939 no 59 0.0169038262910579 193 5382803
SGTC_358 0075-0058 9.45 µM 2.11747593436035 0.00991197709442942 no 60 0.0171097378190409 285 1069125
SGTC_198 3454-2873 16.191 µM 2.11652407645416 0.00993980781509198 no 61 0.0171501298637418 179 710957
SGTC_1291 0993-0025 5.79 µM 2.11493560451517 0.00998640399079982 no 62 0.0172177180522638 158 4353356
SGTC_1019 4262-0212 3.4 µM 2.11165596867929 0.0100832122865566 no 63 0.0173579841264645 265 4677213
SGTC_2661 dactinomycin 12.96 µM 2.1064735573588 0.0102378562733142 no 64 0.0175816188385216 184 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_199 4063-0024 41.6 µM 2.07848757691448 0.0111092090275749 no 65 0.0188322369732608 147 306215
SGTC_1345 1488-0192 31.4 µM 2.06452267053729 0.0115676403037778 no 66 0.0194840933423203 199 658348
SGTC_3010 9080089 71.4286 µM 2.06158647931451 0.0116660911289878 no 67 0.019623561186205 191 17027233
SGTC_2761 levamisole 97.89 µM 2.05325160276897 0.0119495334880838 no 68 0.020024091019218 179 26879 An alkaline phosphatase inhibitor.
SGTC_2794 7785382 27.27 µM 2.04907837819153 0.0120936820037079 no 69 0.0202272256938733 266 2205081
SGTC_465 cgp-37157 41 µM 2.03621449396483 0.0125475421879433 no 70 0.0208644107340558 122 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3060 1327-0027 12.5 µM 2.03065222835691 0.0127483102661253 no 71 0.0211451427904644 195 16000455 YPR107C YTH1
SGTC_588 3970-1144 52.9 µM 2.02839252535001 0.0128306639724199 no 72 0.0212601011833691 240 1888707
SGTC_1923 st058458 19.1 µM 2.02658620271 0.0128968250222703 no 73 0.0213523743791456 260 3534982
SGTC_1254 0550-0035 264 µM 2.02488456992229 0.0129594212227571 no 74 0.0214396091889276 226 15121435
SGTC_2378 9074213 121.43 µM 2.01331034993126 0.0133922008299114 no 75 0.0220409951059607 234 657714
SGTC_1200 1643-0193 18.4 µM 2.01311025543174 0.013399791142745 no 76 0.0220515157914217 218 5403974
SGTC_542 3381-0244 89.3 µM 2.01191402974782 0.0134452458699364 no 77 0.0221145001048543 248 1112843
SGTC_327 1273-0057 3.96 µM 1.99163634512131 0.0142362646429227 no 78 0.0232054862812621 224 3108138
SGTC_1998 st075797 76.8 µM 1.99089984428227 0.0142657340944162 no 79 0.0232459496705242 232 24208315
SGTC_1556 plumbagin 1.48 µM 1.98763331373695 0.0143970712442307 no 80 0.0234261295578127 170 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3314 9135860 59.4275 µM 1.97081054347769 0.0150900721004894 no 81 0.0243727751359902 206 25252478
SGTC_1246 0422-0085 105 µM 1.96373643490421 0.0153899362923036 no 82 0.0247803324940211 272 264295
SGTC_1748 st037455 53.6035 µM 1.95919660102342 0.0155850586483912 no 83 0.0250448835237308 263 580690
SGTC_2085 5307070 144.047 µM 1.94884204029089 0.0160380558676693 no 84 0.0256571457444442 211 2840351
SGTC_3339 9145883 14.936 µM 1.94585994651155 0.0161705931351108 no 85 0.025835782688193 208 2030670
SGTC_2691 st077356 60.2 µM 1.9448120533406 0.0162173883670817 no 86 0.0258988014470342 248 2839272
SGTC_391 gliotoxin 8.33 µM 1.93729542722967 0.0165564672270029 no 87 0.0263546204611216 274 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1327 1436-0082 2.18 µM 1.93401987404066 0.0167061167607746 no 88 0.0265553421810853 226 15992205
SGTC_1889 st059080 5.18 µM 1.92942185911196 0.0169181367598158 no 89 0.026839256094929 242 176925 Isolated from Daphnopsis sellowiana.
SGTC_826 1683-5028 118 µM 1.92697275813933 0.0170320039261997 no 90 0.0269915125040624 211 722377
SGTC_2060 5238662 140 µM 1.91859502134317 0.0174264801498893 no 91 0.0275178030852187 238 790130
SGTC_893 0958-0369 48.9 µM 1.9156059929915 0.0175690981347244 no 92 0.0277076330848735 282 6819948
SGTC_3354 9151612 71.43 µM 1.91541381761722 0.0175783015465816 no 93 0.0277198751836992 237 27261949
SGTC_2116 5511452 16.8835 µM 1.9124800866873 0.0177193116850031 no 94 0.0279073221953489 249 870744
SGTC_1895 st058434 18.3 µM 1.90915333315625 0.0178803791915169 no 95 0.0281211571829802 239 5393175
SGTC_1494 4358-1428 177 µM 1.8938375005676 0.0186381100696113 no 96 0.0291232911814867 259 1564571
SGTC_3108 9121785 49.47 µM 1.89093638182402 0.0187846767001856 no 97 0.0293164185515194 241 17140271
SGTC_1606 st000094 49.2 µM 1.87068682759597 0.0198352602789475 no 98 0.0306942508305771 254 1242210
SGTC_206 4546-0025 72.014 µM 1.87014194489937 0.0198642052032684 no 99 0.0307320545329978 327 6620745 YIL048W NEO1
SGTC_552 k242-0005 476 µM 1.87013729258981 0.0198644524946502 no 100 0.0307323774739268 226 4088318
SGTC_399 oxolinic acid 75 µM 1.86389582437592 0.0201985762011303 no 101 0.0311681676199911 219 4628 A DNA gyrase inhibitor.
SGTC_2288 7946289 167.31 µM 1.84846050945976 0.0210453935061578 no 102 0.0322678760804081 312 1246052
SGTC_3166 9102297 49.47 µM 1.84822599944863 0.0210584874843997 no 103 0.0322848278691295 294 25237072
SGTC_183 3914-0051 30.55 µM 1.83717052121942 0.0216836452813753 no 104 0.0330923630149865 275 1596232
SGTC_1086 cerivastatin 2.18 µM 1.83500386546704 0.0218079839448551 no 105 0.0332525583588458 217 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1581 himbacine 57.9 µM 1.82626066498824 0.0223158684626981 no 106 0.0339055036203576 320 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.80806613049288 0.0234048121846832 no 107 0.0352981043938269 286 688751
SGTC_2921 7974240 10.71 µM 1.80645402918631 0.0235034169820554 no 108 0.0354237243314484 309 2979074 YDR527W RBA50
SGTC_2625 euphol 100 µM 1.80384858373295 0.0236635187989432 no 109 0.0356275235782396 324 6708538 A triterpene alcohol.
SGTC_3132 9126706 49.47 µM 1.79968409743137 0.0239213260561432 no 110 0.0359552667625634 276 850858
SGTC_1920 st075728 45.7 µM 1.79490080126742 0.0242203501694709 no 111 0.0363347531326002 292 3400306
SGTC_349 k015-0014 24 µM 1.79414454907669 0.0242679129072075 no 112 0.0363950500276091 275 2196908
SGTC_1096 rimcazole 32.2 µM 1.79297621844279 0.0243415465444016 no 113 0.036488363394746 247 18528119 A dopamine reuptake inhibitor.
SGTC_1755 st041960 45.185 µM 1.76075229233438 0.0264475948273535 no 114 0.0391401688893302 283 2257073
SGTC_1409 3909-8004 61.9 µM 1.75503031316526 0.0268370454570482 no 115 0.0396270614261927 330 2119279
SGTC_493 zm226600 134 µM 1.75193635195771 0.0270496143040467 no 116 0.0398923764498864 309 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1359 1582-0056 520 nM 1.75175532144334 0.0270620952933663 no 117 0.0399079448800542 336 3661189
SGTC_2004 4023728 41.89 µM 1.74545631751451 0.0274993767418205 no 118 0.0404527349381184 335 360084 YDR527W RBA50
SGTC_512 prima-1 270 µM 1.7431673377298 0.0276597317826342 no 119 0.0406521945013365 301 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2438 5259590 200 µM 1.72931109486851 0.0286471546121652 no 120 0.0418767159989078 313 1201127
SGTC_2010 4012422 159 µM 1.72444191104268 0.0290010301297201 no 121 0.0423140485125003 320 952393
SGTC_3090 9117696 49.47 µM 1.71990351072701 0.0293341290107285 no 122 0.0427249911375952 285 7923821
SGTC_1974 st069448 26.9 µM 1.71981101728632 0.029340950525164 no 123 0.0427333996510043 281 6323587 YNR016C ACC1
SGTC_876 0720-0963 56.8 µM 1.71089415620009 0.0300047930123842 no 124 0.0435503267991843 329 765861
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.71083499286878 0.0300092388551612 no 125 0.0435557889062092 324 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2663 amphotericin b 100 µM 1.71074388048088 0.0300160865858586 no 126 0.0435642017115934 302 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1968 st069590 43.6 µM 1.70890201187242 0.0301547939242033 no 127 0.0437345508980557 291 6384066
SGTC_2858 9025781 8.96 µM 1.70014172066574 0.0308218063094304 no 128 0.0445521356662099 457 4894980 YPL153C RAD53
SGTC_1573 oleylamine 1.06 µM 1.69397692155896 0.0312984814722155 no 129 0.0451348342846219 339 5356789 An amine of the fatty acid oleic acid.
SGTC_2620 irigenin 100 µM 1.67874461752414 0.0325024627661127 no 130 0.0466009131632538 364 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1049 3226-0134 66 µM 1.67635783061267 0.0326945355377659 no 131 0.0468340618043187 379 5702385
SGTC_727 3032-0951 202 µM 1.6757846112848 0.0327408035429625 no 132 0.0468901947292389 328 3652836
SGTC_1186 1319-0216 26 µM 1.6668920169593 0.0334655195943129 no 133 0.0477679392799098 361 4565136
SGTC_716 1683-5115 658 µM 1.66596030902679 0.033542209111428 no 134 0.0478606600812102 390 723597
SGTC_1688 st021091 57.6 µM 1.66520406054136 0.0336045627527723 no 135 0.0479360255735177 286 3656366
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.66266788435938 0.0338143704900951 no 136 0.0481894671340828 342 94937 An inhibitor of serotonin biosynthesis.
SGTC_2077 5212015 200 µM 1.66262390857605 0.0338180179145936 no 137 0.0481938710973672 358 780900
SGTC_2144 5628481 200 µM 1.66217548865701 0.0338552290882815 no 138 0.0482387965817785 312 2818399
SGTC_620 0109-0052 432 µM 1.64732539627644 0.0351066853184146 no 139 0.0497455902742291 333 493037
SGTC_2196 6573537 42.6665 µM 1.64619019763949 0.0352038931177236 no 140 0.0498623033831334 299 2903087
SGTC_2955 9076254 12.21 µM 1.64271853068915 0.0355025452625764 no 141 0.0502205914760015 325 16459619
SGTC_3200 9114385 49.47 µM 1.62799141748902 0.0367926346935415 no 142 0.0517633528065846 332 17018030 YLR208W SEC13
SGTC_2840 9008771 71.43 µM 1.62572706431015 0.0369943501430819 no 143 0.0520038649904028 286 2992978
SGTC_745 0469-0705 296 µM 1.62336410498213 0.0372058127305202 no 144 0.0522557966188143 406 3486736
SGTC_2681 menadione 3.18 µM 1.62089044358702 0.0374282392083105 no 145 0.0525205683634834 358 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_916 4466-0038 42 nM 1.61697182162451 0.0377828154676777 no 146 0.0529421817838214 484 5722064 YGL116W CDC20
SGTC_1795 st049545 62.3 µM 1.61147662823782 0.0382846608969895 no 147 0.0535379386388004 337 5291882
SGTC_1501 4491-0275 38.4 µM 1.61043482074246 0.0383804135377788 no 148 0.0536514820028104 327 5104718
SGTC_1059 3448-6867 171 µM 1.60983184615271 0.0384359221361436 no 149 0.053717285426668 362 3934407
SGTC_1921 5740136 50 µM 1.60936367452721 0.0384790661658214 no 150 0.0537684216928825 430 1774243
SGTC_1432 4049-0298 68.4 µM 1.60721908417045 0.0386772042006602 no 151 0.0540031585260224 326 741646
SGTC_644 1498-1197 63.3 µM 1.60718459305811 0.0386803976028426 no 152 0.0540069403796584 386 6741615
SGTC_2948 9070189 9.45 µM 1.60484928760182 0.0388971148998936 no 153 0.054263488075827 329 6473636 YDL196W YDL196W
SGTC_3031 9088762 49.47 µM 1.5968576444784 0.0396462354412429 no 154 0.0551487215126034 380 205253
SGTC_1098 clofazimine 15.1 µM 1.59378196508348 0.0399376520793188 no 155 0.0554924391618598 413 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_305 1682-2595 20.8 µM 1.59027801460053 0.0402717657150113 no 156 0.0558860760292452 364 226033
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.57400467478177 0.0418533571985401 no 157 0.057743184347417 358 756377
SGTC_1766 st045414 44.774 µM 1.57359693938518 0.0418936214269554 no 158 0.0577903306417616 416 253960
SGTC_1791 st048313 56.1 µM 1.5708690531436 0.0421638100515484 no 159 0.0581065341259637 334 1204976
SGTC_1747 st037496 66.6 µM 1.56737628999326 0.0425118141575766 no 160 0.0585133813183902 423 723305
SGTC_1211 1056-0033 32.3 µM 1.56615755175469 0.0426337893469813 no 161 0.0586558687271923 368 6741922
SGTC_1742 st038235 28.8875 µM 1.56494881985875 0.0427550423976375 no 162 0.0587974551419212 436 564103 YBR002C RER2
SGTC_539 4859-0462 2.54 µM 1.5647896411852 0.0427710310403681 no 163 0.0588161207169241 373 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1074 carmofur 3.8 µM 1.56471578091915 0.0427784515487089 no 164 0.058824783282679 442 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_671 0560-0003 407 µM 1.56459975893769 0.0427901100129517 no 165 0.0588383927294563 376 3238678
SGTC_297 0986-0032 24 µM 1.55828861134055 0.0434281645729572 no 166 0.0595824237218616 332 2847425
SGTC_339 3091-4833 71.4 µM 1.55748992890056 0.0435094557458164 no 167 0.0596771049196694 359 3240077
SGTC_522 1273-0010 11.6 µM 1.55714963967955 0.0435441282180921 no 168 0.0597174808944508 372 5705015
SGTC_1379 2144-0755 36.5 µM 1.55444697499681 0.04382029850131 no 169 0.0600389177753224 420 5392327
SGTC_725 1497-0963 19 µM 1.55403370462509 0.0438626525822375 no 170 0.0600881885939602 372 3549977
SGTC_216 k038-0035 28.382 µM 1.55134178610644 0.0441393429455515 no 171 0.0604098989733195 351 4444231 YPR107C YTH1
SGTC_473 2-arachidonoylglycerol 10 µM 1.55062309441182 0.0442134515825925 no 172 0.0604960171672162 388 5282280 An endocannabinoid.
SGTC_975 1335-0046 28.5 µM 1.55051337570065 0.0442247741606394 no 173 0.0605091728058632 415 16486740
SGTC_311 1315-0136 58 µM 1.54730896944757 0.0445564896115068 no 174 0.0608943799594623 373 6759207
SGTC_193 1273-0060 1.558 µM 1.54586918427218 0.044706185250147 no 175 0.0610680820829808 297 2847393 YHR072W ERG7
SGTC_1662 st014054 52 µM 1.54342007773295 0.0449617510786578 no 176 0.0613644426528044 325 2838777
SGTC_1350 1495-0454 146 µM 1.53456402160857 0.0458957155281306 no 177 0.0624454779681164 466 1069057
SGTC_1927 st060202 13.8 µM 1.52723289372055 0.0466805989557865 no 178 0.0633515547836445 383 688887
SGTC_1248 0469-0687 58.6 µM 1.51145310063579 0.0484065493063614 no 179 0.065336524529429 428 4017482
SGTC_1730 st033808 45.1 µM 1.50994877453393 0.0485737188179542 no 180 0.0655282478377874 480 1045166
SGTC_1794 st048918 76.9 µM 1.50713919284919 0.0488871718004656 no 181 0.0658874912889574 321 672303
SGTC_558 k064-0027 21.3 µM 1.5043971927835 0.0491946413940691 no 182 0.0662395633320913 418 5088526
SGTC_2673 kobusone 100 µM 1.50089262375258 0.049589866505016 no 183 0.0666916681648925 376 6710676 An epoxy ketone and protein crosslinker.
SGTC_2999 9069765 71.4286 µM 1.50076298925364 0.0496045343937549 no 184 0.0667084372724751 437 2097066
SGTC_2690 usnic acid 100 µM 1.49680508920211 0.0500540318412748 no 185 0.0672219908468679 503 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_605 1315-0399 119 µM 1.49381336374027 0.0503959516795025 no 186 0.067612203815625 460 24020461
SGTC_1415 3966-0071 78.1 µM 1.49148972510752 0.0506627988987823 no 187 0.0679164834226849 408 2893185
SGTC_2973 9094665 17.96 µM 1.49145485782412 0.0506668116192657 no 188 0.0679210573198826 479 25237061 YIL048W NEO1
SGTC_967 1306-0166 352 µM 1.49134261784968 0.0506797305374013 no 189 0.067935782597428 440 4437607
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.48728471548625 0.0511485631278228 no 190 0.0684698148116901 430 16623 A steroid.
SGTC_18 0111-0177 500 nM 1.48666716674651 0.051220213668667 no 191 0.0685513692504455 538 721752
SGTC_2757 clomiphene 4.22 µM 1.48639382825958 0.0512519530077566 no 192 0.0685874906659465 493 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_321 4534-3890 65.3 µM 1.47917183749312 0.0520962338411364 no 193 0.0695471971867878 409 699746
SGTC_1172 0370-0043 85 µM 1.47662551173198 0.0523965308341485 no 194 0.0698880246109262 405 376585
SGTC_1715 st032160 10.2275 µM 1.47574200365445 0.0525010465600565 no 195 0.0700065826588186 424 5289825
SGTC_2198 6589944 200 µM 1.475146513889 0.0525715840977018 no 196 0.070086578752619 337 5290268
SGTC_1989 st071868 50.2 µM 1.47416964888415 0.0526874595464128 no 197 0.0702179597861761 461 16414057
SGTC_1948 st076329 66.6 µM 1.46538076567242 0.0537391306834127 no 198 0.0714085310821228 407 24208413
SGTC_1482 3346-2049 8.48 µM 1.46369489618467 0.0539427482011762 no 199 0.0716386653240994 429 3826804
SGTC_2754 granisetron 64.02 µM 1.46029551645079 0.054355178852425 no 200 0.072104436877681 469 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1965 Pectolinarigenin 58.4 µM 1.45354448086364 0.0551816436603271 no 201 0.0730363194858314 430 5320438 An anti-inflammatory.
SGTC_1793 st048256 72.231 µM 1.45101874748967 0.0554933846660421 no 202 0.0733873199559529 406 672022
SGTC_2645 abamectin 100 µM 1.44933595158713 0.0557018559456124 no 203 0.0736218928389274 451 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_65 0798-0905 34.986 µM 1.44596910628271 0.0561208087360241 no 204 0.0740929335546349 576 3602145
SGTC_373 0844-0104 25.9 µM 1.44542012576231 0.0561893560391166 no 205 0.0741699568549827 474 5375804
SGTC_3265 9137266 49.47 µM 1.44233779990842 0.056575450852309 no 206 0.0746035507650228 378 17224265
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.43638703602937 0.0573267595405494 no 207 0.0754461199995771 327 1241132 A phosphatase inhibitor.
SGTC_1176 0848-0131 83.3 µM 1.43388882006642 0.057644500053165 no 208 0.0758019963881246 511 6769040
SGTC_1675 st018485 24.5 µM 1.43120471541957 0.0579874248481471 no 209 0.0761857762639682 457 3323024
SGTC_1631 benzylvanillin 81.9 µM 1.41449251229104 0.0601587963275262 no 210 0.0786086721669576 493 75506
SGTC_548 1436-0017 110 µM 1.41125424518742 0.0605868056721394 no 211 0.0790848302617679 572 9677137
SGTC_2048 5246248 200 µM 1.40673882193899 0.0611875920177434 no 212 0.0797524247209966 423 677046
SGTC_1941 st076221 61.8 µM 1.40245263055651 0.0617621759428493 no 213 0.0803900631917006 553 2828568
SGTC_2985 9022375 71.43 µM 1.39912293990319 0.0622114366737507 no 214 0.0808880598582977 492 4939335
SGTC_2789 5281112 71.43 µM 1.39733904035886 0.0624531769956453 no 215 0.0811558205512524 485 765948
SGTC_259 usnic acid 108.925 µM 1.39653924786467 0.0625617962278819 no 216 0.081276085151541 492 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_251 melphalan 456.522 µM 1.39590817300437 0.0626476059401017 no 217 0.0813710745842551 547 460612 A DNA alkylator.
SGTC_3096 9117468 49.47 µM 1.39552376315548 0.0626999205897046 no 218 0.0814289770076816 359 41316311
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.39435911036566 0.0628586269895382 no 219 0.0816045946247836 517 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_813 k007-0158 173 µM 1.39342663856302 0.0629859197279174 no 220 0.0817454074800008 560 6523916
SGTC_2767 sibutramine 71.45 µM 1.39310449575351 0.0630299424303261 no 221 0.0817940969096193 488 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_989 1501-0895 10.3 µM 1.39172836472595 0.0632182687050898 no 222 0.0820023347772669 448 2830112
SGTC_1006 4099-6547 255 µM 1.38810043813809 0.0637168579433273 no 223 0.0825532315974021 494 3146833
SGTC_2541 muurolladie-3-one 83.07 µM 1.38587511683443 0.0640241962474492 no 224 0.0828925200710579 484 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_130 0136-0219 337.655 µM 1.37994308163869 0.064849099676944 no 225 0.0838020852433628 492 234244
SGTC_2341 7987486 176.74 µM 1.37853819173148 0.0650456657621027 no 226 0.084018592354953 529 1258686
SGTC_2402 5553605 200 µM 1.37825832104471 0.0650848792311556 no 227 0.0840617732544699 508 6758546
SGTC_1725 st036284 20.55 µM 1.37725777188006 0.0652252190407365 no 228 0.0842162830011811 541 707914
SGTC_1653 st012112 65 µM 1.36454831826388 0.0670283803653919 no 229 0.0861975289256032 470 720429
SGTC_2493 resveratrol 26.09 µM 1.36241002042918 0.0673355058804756 no 230 0.0865342615765953 454 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1133 3473-0247 50 µM 1.3602791918627 0.0676426395740617 no 231 0.0868707952593063 535 711311
SGTC_1009 4106-0057 9.87 µM 1.35906475275989 0.0678181701617666 no 232 0.0870630353740321 529 2928005
SGTC_2311 7694451 200 µM 1.3576887780346 0.0680174733930511 no 233 0.0872812295681927 504 2163142
SGTC_2523 spermine 47.74 µM 1.35200657663235 0.0688453052045779 no 234 0.0881866057103176 488 1103 A DNA binding polyamine.
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.35195015416688 0.0688535640881521 no 235 0.0881956307790481 494 6708760
SGTC_3148 9097893 49.47 µM 1.34857773133102 0.0693485937433267 no 236 0.088736318673123 491 17174100
SGTC_2522 biochanin a 4.94 µM 1.34661328533238 0.0696382108907164 no 237 0.0890524065672832 464 5280373 A possible chelator.
SGTC_1876 myriocin 605 nM 1.34567648765703 0.0697766499324667 no 238 0.089203436160559 503 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1258 0671-0043 57.1 µM 1.34483420994055 0.0699013016695166 no 239 0.0893393899852026 526 4298767
SGTC_2255 7941087 197.44 µM 1.34149887292581 0.0703965936712994 no 240 0.0898792677042106 590 935561
SGTC_1734 st037168 69.4 µM 1.34040385929521 0.0705597883775586 no 241 0.0900570408567794 508 708907
SGTC_1106 tegaserod maleate 11.7 µM 1.33824930944123 0.0708817392234041 no 242 0.0904075899864117 548 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1309 pyrazolanthrone 13.4 µM 1.33285422324984 0.0716928683968221 no 243 0.0912898237074007 555 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_843 0310-0051 143 µM 1.33273347969498 0.071711102820291 no 244 0.0913096411136927 521 2065037
SGTC_1500 4488-1866 171 µM 1.3323508446271 0.0717689110193731 no 245 0.091372463336306 570 2900003
SGTC_1724 st037281 8.293 µM 1.33176161392343 0.0718580014145246 no 246 0.091469267729068 546 574124 YDL195W SEC31
SGTC_1693 xanthone 101.9 µM 1.33077731198661 0.072007014860153 no 247 0.0916311476777219 554 7020 An insecticide.
SGTC_2315 7733312 200 µM 1.32818478223501 0.0724006316468272 no 248 0.0920585352096222 482 726316
SGTC_807 1315-0151 48 µM 1.32452745512165 0.0729587142161057 no 249 0.0926639655283731 605 4011080
SGTC_3153 9100258 49.47 µM 1.32418977806463 0.0730104069637677 no 250 0.0927200124140033 500 25236848
SGTC_2148 5546263 113.568 µM 1.321284284341 0.0734563486795043 no 251 0.0932032960478621 505 792097
SGTC_2616 abietic acid 100 µM 1.31685753114636 0.0741397771925306 no 252 0.0939431921118711 565 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1783 st039459 87.517 µM 1.31636151786139 0.074216656282598 no 253 0.0940263660341793 588 729761
SGTC_1760 st045453 10.4495 µM 1.31300671106907 0.0747382306489817 no 254 0.0945903433935458 587 3323419 YIL048W NEO1
SGTC_1565 sinapyl alcohol 95.1 µM 1.31065205596991 0.0751059779217935 no 255 0.0949876717402416 509 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1818 st052136 56.3 µM 1.30877169557247 0.0754006400506335 no 256 0.0953058487020367 534 674169
SGTC_2067 5224629 34.075 µM 1.30252664786818 0.0763855952955562 no 257 0.0963682072849427 537 2835000
SGTC_1338 1486-1223 76 µM 1.29378168411767 0.0777812438341344 no 258 0.0978704204950769 590 3444526
SGTC_803 4488-1585 147 µM 1.29178636577035 0.0781023810041883 no 259 0.0982155691471355 545 747204
SGTC_798 1287-0182 476 µM 1.29164047145456 0.0781259014148206 no 260 0.0982408407711204 608 1649755
SGTC_2476 5806916 10.51 µM 1.29076105392289 0.0782677908835312 no 261 0.0983932732255259 523 2870194
SGTC_816 0325-0417 81.3 µM 1.29069569135026 0.0782783445937827 no 262 0.0984046096552739 511 68101
SGTC_2749 bexarotene 57.39 µM 1.28815887022898 0.0786887844585932 no 263 0.0988453329978082 546 82146 An retinoic acid receptor inhibitor.
SGTC_1757 st041620 31.8375 µM 1.28695763628465 0.0788837037345391 no 264 0.0990545271906604 571 5289815
SGTC_801 0866-0028 10.1 µM 1.2856502133939 0.0790962693223363 no 265 0.0992825819652477 595 6849771
SGTC_2052 5265182 7.135 µM 1.28480331564694 0.0792341923639706 no 266 0.0994305117201039 580 1239884
SGTC_3177 9107506 49.47 µM 1.28227783331591 0.0796465653867959 no 267 0.0998726005265027 510 8897194
SGTC_958 1222-0007 33 µM 1.28085069778972 0.0798803119273203 no 268 0.100123056368044 619 7312461
SGTC_442 cape 100 µM 1.27992160429212 0.0800327641294558 no 269 0.1002863543299 509 5281787
SGTC_2819 7996655 46.38 µM 1.27986042724849 0.0800428102033813 no 270 0.100297113656573 483 6456960
SGTC_2796 7949634 45.45 µM 1.27948126195062 0.0801050953912198 no 271 0.100363816993963 538 2971588
SGTC_3061 glucosamine 200 µM 1.2768035039808 0.0805460120852939 no 272 0.100835814086407 534 91431 and experimental redox chemotherapeutic
SGTC_1739 st037196 92.5 µM 1.27608266462581 0.0806650172997322 no 273 0.100963149455893 591 612214
SGTC_2919 7978188 46.38 µM 1.2760527192082 0.0806699639366161 no 274 0.10096844181129 582 2980291
SGTC_230 MPP+ 141.667 µM 1.27546383219796 0.0807672878202546 no 275 0.101072558910417 552 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_905 2-aminofluorene 215 µM 1.26825747920501 0.0819654544251231 no 276 0.102353008216309 605 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1879 gemcitabine 100 µM 1.26592346699718 0.082356377252137 no 277 0.102770241923619 575 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2080 5212524 12.4 µM 1.26485859654229 0.0825351976961536 no 278 0.102961010813677 543 260183
SGTC_2331 7980721 200 µM 1.25361394577682 0.0844413510972108 no 279 0.104991179907636 580 2981221
SGTC_2772 vinpocetine 57.06 µM 1.25341808274399 0.0844748433325121 no 280 0.105026797008061 555 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2330 7979373 200 µM 1.25327074026186 0.0845000452066741 no 281 0.105053596556761 575 1863007
SGTC_662 k832-1615 104 µM 1.25129841526542 0.0848379405377848 no 282 0.105412811721675 562 5878478
SGTC_1690 st023502 41.2 µM 1.24982458859764 0.0850910945956654 no 283 0.105681815911629 559 24207482
SGTC_1638 st008370 60.6 µM 1.24711125745051 0.0855586338530459 no 284 0.106178352873398 593 24207134
SGTC_740 k014-0057 261 µM 1.24710139971709 0.0855603359579541 no 285 0.10618015989621 654 4012779
SGTC_939 1165-0479 45.3 µM 1.24572234380245 0.085798703333591 no 286 0.106433173854378 590 1377347
SGTC_584 0986-0246 15.4 µM 1.24550668857752 0.0858360238579607 no 287 0.106472779222114 640 53315 YDR232W HEM1
SGTC_1602 st001878 87.6 µM 1.24261374203436 0.0863378422220638 no 288 0.107005101757383 578 595405 YLR310C CDC25
SGTC_976 1348-1067 47.6 µM 1.24218817739589 0.0864118465458786 no 289 0.107083570334005 654 5310671 YGL099W LSG1
SGTC_112 phenothiazine 287.218 µM 1.24119937928341 0.0865839784758606 no 290 0.107266052043687 603 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1979 st071809 45.3 µM 1.23989552784391 0.0868113471562346 no 291 0.10750701912255 595 4976333
SGTC_312 4092-0653 6.84 µM 1.23867832914257 0.087024007493884 no 292 0.107732323619125 687 1148278
SGTC_2432 5630864 12.22 µM 1.23722460610979 0.0872785012738264 no 293 0.108001854440581 583 5714970
SGTC_142 0335-0849 62.6745 µM 1.23682155645742 0.08734915882682 no 294 0.108076668675988 713 3889043 YPR107C YTH1
SGTC_2275 7947463 200 µM 1.23363486681114 0.087909312960171 no 295 0.10866949723565 550 1225414
SGTC_2423 st077119 87.2 µM 1.23316766966435 0.0879916612216484 no 296 0.108756607389305 598 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1710 st031758 61.5 µM 1.22765126221896 0.0889683374030522 no 297 0.109788954764985 564 5394341
SGTC_408 cantharidin 100 µM 1.2264352398947 0.0891847147498239 no 298 0.110017465764954 615 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_577 r071-0003 38.6 µM 1.22573639705923 0.0893092429462208 no 299 0.110148944369447 746 4568517 YMR134W ERG29
SGTC_1036 k216-0215 33.5 µM 1.22421990427779 0.0895799146624793 no 300 0.110434641237569 635 622330
SGTC_234 nsc-17383 10.7 µM 1.22404381142013 0.0896113841414361 no 301 0.110467850323828 666 408974
SGTC_1868 st057644 42.7 µM 1.22326223429294 0.0897511586710732 no 302 0.110615333182333 634 688665
SGTC_926 2268-1401 59.4 µM 1.22324264091285 0.089754664764144 no 303 0.11061903224688 602 2931578
SGTC_1885 st057546 99.9 µM 1.21874886095126 0.0905614862616905 no 304 0.111469763312243 636 702008
SGTC_1261 0712-0010 12.7 µM 1.21702976732191 0.0908715551256962 no 305 0.111796445177037 640 2840123
SGTC_2389 9091542 195.52 µM 1.21691005502055 0.0908931766505396 no 306 0.111819219756094 635 3626624 YOL127W RPL25
SGTC_210 3551-0445 56.827 µM 1.21656700740236 0.0909551564403632 no 307 0.111884500976705 619 2865180 YOR207C RET1
SGTC_1929 genistein trimethyl ether 50.5 µM 1.21631649817033 0.091000436752054 no 308 0.11193218955752 607 136420
SGTC_394 menadione 8.33 µM 1.21611538358352 0.0910368009291946 no 309 0.111970485566609 638 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1942 st076330 65.2 µM 1.2140111248532 0.0914179252969101 no 310 0.112371737998732 591 24208414
SGTC_2834 9001755 58.44 µM 1.21204734224523 0.0917746722836068 no 311 0.112747129459251 549 2989575
SGTC_2799 7812892 81.82 µM 1.20976915003045 0.0921898268755738 no 312 0.113183743540889 649 20205235
SGTC_2121 5257820 149.641 µM 1.20872974675835 0.0923796983182576 no 313 0.113383344750497 661 791256
SGTC_3018 9082602 49.47 µM 1.20560821903965 0.0929516580904249 no 314 0.113984294302066 654 17332089
SGTC_266 formosanin C 406 nM 1.20486732163416 0.0930877968693298 no 315 0.114127262840801 635 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1938 st074717 56.4 µM 1.2022061949984 0.0935779901288306 no 316 0.11464182486182 553 17250979
SGTC_1257 0669-0121 16 µM 1.20218269009352 0.0935823283301427 no 317 0.114646377172043 678 4307855
SGTC_2379 9035213 200 µM 1.1999465190238 0.0939957284735681 no 318 0.115080055814744 670 646551
SGTC_1371 2421-0008 32.7 µM 1.1958657718269 0.0947536055162244 no 319 0.115874472081344 615 2827552
SGTC_1882 5615643 20 µM 1.19394993952516 0.0951109636329931 no 320 0.116248775433233 574 2253075
SGTC_1799 st045822 46.1415 µM 1.1939378123416 0.0951132288605142 no 321 0.116251147496102 604 3674992
SGTC_2968 9090663 33.37 µM 1.19151147231863 0.095567242718756 no 322 0.116726427813465 626 25236811
SGTC_2602 kawain 100 µM 1.19145366008398 0.0955780798946027 no 323 0.116737769063671 698 5369129
SGTC_2636 apigenin dimethyl ether 100 µM 1.18827566361243 0.0961752023832848 no 324 0.117362411211213 648 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3325 9138760 55.175 µM 1.18444978345585 0.0968976899922989 no 325 0.118117531670683 624 43844959
SGTC_2524 avocatin b 10.57 µM 1.18405587952019 0.0969723013315009 no 326 0.118195471814597 576 6710748
SGTC_1939 st074455 53.6 µM 1.1814555354646 0.0974659040946932 no 327 0.118710903663948 637 1644229
SGTC_589 1227-0070 34.1 µM 1.17534206415945 0.0986336304550696 no 328 0.119928946031479 645 2841384
SGTC_33 0986-0033 35.816 µM 1.17529659530608 0.0986423536020074 no 329 0.119938038089191 598 2848082
SGTC_289 k017-0060 526 µM 1.17136111535347 0.0993995120406295 no 330 0.120726827620948 606 5512909
SGTC_1010 4112-3296 15.2 µM 1.16980506193791 0.0997000547375428 no 331 0.121039713072273 673 704384
SGTC_2639 lactacystin 53 µM 1.16777803065978 0.100092559121462 no 332 0.121448156030417 677 3870 A proteasome inhibitor.
SGTC_318 1488-0629 67.2 µM 1.16638944455726 0.100362088493902 no 333 0.121728512132026 606 3662576
SGTC_2278 7948257 134.34 µM 1.16602962237327 0.100432017555059 no 334 0.121801234506879 644 1247028
SGTC_887 0885-0007 9.62 µM 1.16547233646777 0.100540392547089 no 335 0.12191392580463 664 5719458
SGTC_600 1495-0418 41.6 µM 1.16407242296432 0.100813009021601 no 336 0.122197331628796 620 5377768
SGTC_922 1866-0035 480 µM 1.16326950156801 0.100969611429899 no 337 0.122360087807331 752 3156169
SGTC_2626 ethyl orsellinate 100 µM 1.16192903387931 0.10123145232749 no 338 0.122632146226049 615 75653 A natural product.
SGTC_3017 9080681 49.47 µM 1.16113549271668 0.101386692033064 no 339 0.122793401440045 638 16451914
SGTC_763 3453-1109 128 µM 1.16003757170398 0.101601763132977 no 340 0.123016754694077 685 1560353
SGTC_540 1187-0821 17.3 µM 1.15904799919165 0.101795894401565 no 341 0.123218310196425 626 847520
SGTC_3162 9099653 49.47 µM 1.15680756475174 0.102236413286759 no 342 0.123675495248265 599 25237511
SGTC_3027 9089541 49.47 µM 1.15516671081801 0.10255991993172 no 343 0.124011081983996 672 9943819
SGTC_340 k038-0059 454 µM 1.15508872134934 0.10257531464456 no 344 0.124027048204104 668 23733424
SGTC_443 clozapine 122 µM 1.15501232587886 0.102590396339134 no 345 0.124042689491066 570 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_683 panaxydol 45 µM 1.15238127167072 0.103110792887838 no 346 0.124582216742049 698 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.1516669379839 0.103252411386247 no 347 0.124728981630246 645 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2265 7929201 200 µM 1.15041035071384 0.103501875693682 no 348 0.124987449480864 643 1265108
SGTC_2065 5221596 34.26 µM 1.14919109622938 0.103744346357357 no 349 0.125238595748132 640 788581
SGTC_3150 9097574 49.47 µM 1.14882035024653 0.103818157497125 no 350 0.125315033104805 640 17217476
SGTC_1971 st069429 63.5 µM 1.1487056310076 0.103841004455792 no 351 0.125338691570428 631 1246522 YGL099W LSG1
SGTC_3101 9120531 49.47 µM 1.14801630595415 0.103978364075781 no 352 0.125480916234914 674 24824904
SGTC_1468 k284-1086 134 µM 1.14743250251111 0.104094799749015 no 353 0.125601457262552 720 15996457
SGTC_1891 st059073 26.2 µM 1.14450866557389 0.104679361774022 no 354 0.126206373102554 717 688754
SGTC_694 1315-0438 43.2 µM 1.14284237359828 0.105013564853251 no 355 0.12655202103413 568 6793154
SGTC_874 0599-0792 117 µM 1.14199134491551 0.10518455072661 no 356 0.126728808661821 744 765305
SGTC_1278 0874-0585 172 µM 1.13885139931912 0.10581716101672 no 357 0.127382569693721 687 766306
SGTC_3183 9108214 49.47 µM 1.13783350720722 0.106022826586967 no 358 0.127595005301486 552 4974831
SGTC_320 4092-0846 5.34 µM 1.13390373491082 0.106819548772251 no 359 0.128417465141495 678 1359356
SGTC_1205 4161-2785 76 µM 1.13266060619141 0.107072477899331 no 360 0.12867840341716 607 3498106
SGTC_2951 9072950 58.06 µM 1.12968314892708 0.107680032064073 no 361 0.12930488013415 730 16488155
SGTC_1007 4101-0031 70 µM 1.12781643227364 0.108062202595691 no 362 0.129698726078253 694 1146276
SGTC_25 0118-0223 35.662 µM 1.12238462448463 0.109179802352097 no 363 0.130849469513376 685 5333628
SGTC_2382 9035899 200 µM 1.1216521502795 0.109331142832517 no 364 0.131005184443911 699 6462679
SGTC_2678 equilin 100 µM 1.12012298324025 0.109647577931593 no 365 0.131330678913328 704 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_133 0724-0033 378.92 µM 1.11983209130554 0.109707847432533 no 366 0.13139266056903 649 280309
SGTC_907 3448-6986 75.5 µM 1.11792968497936 0.110102590794218 no 367 0.131798512802001 749 590582
SGTC_3305 9127027 53.8275 µM 1.11322786798623 0.111082571646708 no 368 0.132805288370047 694 41905295
SGTC_411 enrofloxacin 100 µM 1.11066053424129 0.111620299830901 no 369 0.133357247920022 693 71188 A bacterial gyrase inhibitor.
SGTC_534 k292-0788 63.4 µM 1.10890180504705 0.111989739030323 no 370 0.133736272536045 777 4146317
SGTC_769 0302-0231 76 µM 1.10838242159887 0.112099007907133 no 371 0.133848346633077 796 571869 YER009W NTF2
SGTC_3209 9113616 49.47 µM 1.10833924923773 0.112108094020127 no 372 0.133857665397974 741 16649353
SGTC_1916 st067606 49.2 µM 1.10477230635074 0.112860617091198 no 373 0.134629131640214 746 19590279
SGTC_2000 st075254 36.4 µM 1.1042420641446 0.112972790201566 no 374 0.134744073599961 667 17234175
SGTC_1561 5-methoxyflavone 52.9 µM 1.10325465246047 0.113181889854662 no 375 0.13495829676853 653 94525
SGTC_1138 3761-0006 1.03 µM 1.09870197419141 0.114149561262779 no 376 0.135949040590301 717 12061087
SGTC_2044 5102272 200 µM 1.09623388153214 0.114676610600516 no 377 0.136488217923531 651 592666
SGTC_2161 5662504 8.5105 µM 1.09527560900472 0.114881711069191 no 378 0.136697954942745 672 2859334
SGTC_1774 st048371 48.465 µM 1.09488604743523 0.114965164055545 no 379 0.136783281213162 726 4242727
SGTC_3261 9137475 49.47 µM 1.09272993276858 0.115427832793803 no 380 0.137256196682496 477 17027690
SGTC_2866 9034245 58.44 µM 1.09217675447397 0.115546749264232 no 381 0.137377708883586 693 6462273
SGTC_1388 3346-4487 254 µM 1.09193491476271 0.115598764765376 no 382 0.137430854926506 759 3345614
SGTC_944 3370-0224 231 µM 1.09109142817012 0.115780314193285 no 383 0.137616327121318 711 4580514
SGTC_1429 4049-0205 9.46 µM 1.09090299830144 0.115820898907141 no 384 0.137657783837344 776 22774478
SGTC_2078 5212016 200 µM 1.09010842508748 0.115992148107919 no 385 0.137832692734533 670 1899708
SGTC_654 1124-0271 80.9 µM 1.08798813414892 0.116450000235242 no 386 0.138300172945052 729 5403748
SGTC_2849 9019321 12.99 µM 1.08783909371581 0.116482231936325 no 387 0.138333073880272 673 16489627
SGTC_2576 guaiol 23.12 µM 1.08756111402324 0.116542365135885 no 388 0.138394452635678 759 227829
SGTC_2483 5729050 27.16 µM 1.08440808600278 0.117225976829175 no 389 0.139091950053602 811 2865180
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.08427695675414 0.11725446850767 no 390 0.139121009557396 750 23665772 A membrane-active detergent.
SGTC_1435 4092-0789 56.7 µM 1.08334731788521 0.117456600498501 no 391 0.139327144970157 727 2248285
SGTC_884 0851-0618 334 µM 1.08261773526353 0.117615406833415 no 392 0.139489065962343 741 9642473
SGTC_175 3793-3120 23.7 µM 1.08171366999743 0.117812403126589 no 393 0.139689888520602 669 5322297
SGTC_45 0kpi-0036 14.9 µM 1.0815649714979 0.117844826953456 no 394 0.139722938152211 671 2795021
SGTC_3218 9131285 49.47 µM 1.0776678228836 0.118696855457961 no 395 0.140591011513937 799 17156417
SGTC_1751 st044839 27.194 µM 1.077529786735 0.118727113721819 no 396 0.140621825462784 722 5291326
SGTC_773 4358-1457 44.6 µM 1.07545496146294 0.119182583185614 no 397 0.141085543088832 784 1186886
SGTC_454 lyso-paf C-16 6.67 µM 1.075301537475 0.119216312009314 no 398 0.141119874047391 686 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1229 0139-0193 12.2 µM 1.07434935780444 0.119425790434859 no 399 0.141333065446114 778 3090752
SGTC_3164 9100705 49.47 µM 1.07357062888096 0.119597302847146 no 400 0.14150758371732 676 17174235
SGTC_524 r073-0010 27.8 µM 1.07346909299054 0.119619678580868 no 401 0.141530349333993 714 2772106
SGTC_106 0092-0003 11.579 µM 1.07224354088802 0.119889989679907 no 402 0.141805329193062 655 1072148
SGTC_859 0439-0102 54.6 µM 1.0708753467943 0.120192270685347 no 403 0.142112741119154 797 610143
SGTC_2252 omeprazole 400 µM 1.06822876989903 0.120778513467943 no 404 0.142708665065654 641 4594 A proton pump inhibitor.
SGTC_1652 st011932 78 µM 1.0661800561944 0.121233703605365 no 405 0.143171127936983 703 1551076
SGTC_276 colchicine 750 µM 1.0633400829263 0.121866691883281 no 406 0.143813877025043 762 2833 A microtubule depolymerizer.
SGTC_1877 wortmannin 25 µM 1.06307298691612 0.121926342880864 no 407 0.143874426789605 784 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.06250731573758 0.122052742873348 no 408 0.144002719309519 770 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_255 tunicamycin 200.472 nM 1.06162241704404 0.122250659208163 no 409 0.144203566374687 738 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1055 3448-0672 86 µM 1.06155786886227 0.122265104858035 no 410 0.14421822437965 725 748378
SGTC_2237 6667747 47.222 µM 1.05912813318589 0.122809742602573 no 411 0.144770714533823 709 729940 YDL015C TSC13
SGTC_565 1418-0001 44.5 µM 1.05881168642473 0.122880800801974 no 412 0.144842775163867 797 2862145
SGTC_12 0849-0099 9.267 µM 1.05792096347445 0.1230809676283 no 413 0.145045738482952 737 6071388
SGTC_1188 1403-0014 4.57 µM 1.05726721629891 0.123228025668328 no 414 0.145194825409337 798 9614867
SGTC_3225 9130819 49.47 µM 1.05720763844337 0.123241433608649 no 415 0.145208417253673 750 4547121
SGTC_502 l-744,832 89.3 µM 1.05519975003616 0.123693904911271 no 416 0.145666989233651 756 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_968 1309-0633 340 µM 1.051851003182 0.124451119556809 no 417 0.146433957280068 740 3761976
SGTC_1644 st010134 20.9 µM 1.04907310307691 0.125081709855791 no 418 0.147072237115624 719 3818134
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.04445132446845 0.126135803657607 no 419 0.148138314159657 750 390807
SGTC_2345 9052315 157.45 µM 1.04421650458068 0.126189524077391 no 420 0.1481926162971 726 6469265
SGTC_1334 1486-0610 236 µM 1.04400042090701 0.126238972247202 no 421 0.14824259744722 773 3742339
SGTC_1995 st072814 61.1 µM 1.04389693039372 0.126262659598202 no 422 0.148266539273851 742 5769371
SGTC_2215 7188065 200 µM 1.04310578865549 0.126443841853308 no 423 0.148449650006417 726 940217
SGTC_2829 7992743 58.44 µM 1.04058032327416 0.127023419557148 no 424 0.149035183652552 765 16462845
SGTC_2506 ethyl hematommate 54.16 µM 1.04047664407455 0.127047252697574 no 425 0.149059254783029 687 3940691 An allergen.
SGTC_653 0203-0016 55.2 µM 1.03966849389665 0.127233131989197 no 426 0.14924697148082 777 295302
SGTC_2770 toltrazuril 17.5 µM 1.03367556152483 0.128617445615305 no 427 0.150643930812861 802 68591 Kills coccidiodes.
SGTC_2808 7946468 45.46 µM 1.02968450614695 0.129545121329717 no 428 0.151579065569869 797 2970879
SGTC_67 0335-0847 266 µM 1.0285138321911 0.129818108339514 no 429 0.151854093817973 882 4552207 YOR254C SEC63
SGTC_1476 4112-3294 3.34 µM 1.02765880588879 0.130017741667312 no 430 0.152055175853196 771 704369
SGTC_2183 6420625 130.508 µM 1.02652930485069 0.130281785546197 no 431 0.152321078865105 823 2897619
SGTC_902 1120-0002 2.07 µM 1.02607114912832 0.130388994468051 no 432 0.152429024154687 792 3280475
SGTC_2298 7976326 193.81 µM 1.02539546242112 0.130547217206333 no 433 0.152588314176655 701 2235818
SGTC_2970 9090938 41.86 µM 1.02438986390159 0.130782939763894 no 434 0.152825583805391 839 17217104
SGTC_38 0929-0051 58.268 µM 1.02288003184285 0.131137411989359 no 435 0.153182285884947 835 1379719
SGTC_1835 st008666 49.2 µM 1.01910707985889 0.132026109736447 no 436 0.154076066693994 671 690455
SGTC_895 0964-0006 13.7 µM 1.01892948414342 0.132068043521605 no 437 0.154118222484055 776 6738897
SGTC_222 nsc-310342 10.666 µM 1.01711337997903 0.132497388055106 no 438 0.154549747969182 702 432556
SGTC_1004 4084-0029 199 µM 1.01472254584722 0.133064069302379 no 439 0.155119051884817 825 716894 YLR208W SEC13
SGTC_2473 5854593 8.94 µM 1.01386314850202 0.133268172737138 no 440 0.155324028901674 765 2872951
SGTC_1162 k048-0130 20.1 µM 1.00848930537295 0.134549323142955 no 441 0.156609809665223 789 6797406
SGTC_2932 9016711 44.54 µM 1.00803261675982 0.134658588387561 no 442 0.156719402080789 828 7117328
SGTC_3136 9095672 49.47 µM 1.00729160341123 0.134836009415583 no 443 0.156897331801083 701 17217380
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.00428467703932 0.135557604009728 no 444 0.157620708621742 875 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3259 9138485 49.47 µM 1.00421098552195 0.135575321467361 no 445 0.157638464068162 861 17646153
SGTC_1077 5-fluorocytosine 377 nM 1.00264565896773 0.135952043617102 no 446 0.158015928751638 787 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2262 9014885 67.46 µM 0.999222371099566 0.136778411090672 no 447 0.158843490520555 737 6457424
SGTC_1988 st071872 53.4 µM 0.998034435104254 0.137065974774445 no 448 0.159131330513405 838 16414116
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.996973967916689 0.137323030810932 no 449 0.159388572952637 795 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2424 5537928 59.2 µM 0.99644453635355 0.137451487551017 no 450 0.159517101457656 831 5382802
SGTC_835 0312-0010 67.2 µM 0.99618766426354 0.137513842344758 no 451 0.159579485957068 768 1626196
SGTC_1332 1480-0653 17.5 µM 0.995337996815673 0.137720233686121 no 452 0.159785951739121 808 5749438
SGTC_396 dithiazanine 1.25 µM 0.993263076520593 0.13822513728098 no 453 0.160290883203551 762 10578 An antihelmenthic.
SGTC_2820 7989630 71.43 µM 0.992861418234053 0.138323020961738 no 454 0.16038874701634 690 2984098
SGTC_2229 7354935 190 µM 0.989780143670833 0.13907549561267 no 455 0.161140796123716 763 318112
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.988501989727588 0.139388448306847 no 456 0.161453430232262 863 676296 Flavone; oxidizing agent.
SGTC_135 0933-0004 26.348 µM 0.986118779383596 0.13997324978953 no 457 0.162037414652542 765 21230617 YGL099W LSG1
SGTC_335 4077-0256 27.6 µM 0.982665185719001 0.140823661049152 no 458 0.16288612526694 912 3121989
SGTC_2998 9066762 71.4286 µM 0.98107432825764 0.141216569895993 no 459 0.163278044502524 838 4945196
SGTC_530 4358-1714 28 µM 0.980133991849195 0.141449162679621 no 460 0.163509991038931 863 1564641
SGTC_1383 3049-0032 20.7 µM 0.979977117399025 0.141487990924226 no 461 0.163548707034106 842 712864
SGTC_3270 9137563 49.47 µM 0.979960432612596 0.141492121027136 no 462 0.163552825123756 775 17015724
SGTC_2346 9031566 143.75 µM 0.979484136609867 0.141610056390675 no 463 0.163670411491049 828 4771086
SGTC_2096 5468907 200 µM 0.977903626783628 0.142001882514459 no 464 0.164060995607911 822 759785
SGTC_2320 7373003 200 µM 0.976854423929667 0.142262396632827 no 465 0.164320613928122 798 5415828
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.975469524638838 0.142606758095274 no 466 0.16466370573325 897 688788
SGTC_39 0986-0283 58.349 µM 0.974527079905805 0.142841423279123 no 467 0.164897450060438 904 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_973 1325-0077 65.9 µM 0.973181734854456 0.143176861111339 no 468 0.165231493506452 899 2835149
SGTC_2111 5486399 200 µM 0.97122706317747 0.143665171135335 no 469 0.165717609993027 871 689674
SGTC_685 1278-0033 54.9 µM 0.968741888598073 0.144287630838247 no 470 0.166336993536809 856 3590572
SGTC_2933 9026794 32.47 µM 0.96731619637732 0.144645542233627 no 471 0.166692994733245 836 17586027
SGTC_833 3852-0053 558 µM 0.963552002191994 0.145593392278175 no 472 0.167635290324204 908 3123681
SGTC_2150 5556613 200 µM 0.961438498525984 0.146127413823267 no 473 0.168165867409403 875 743190
SGTC_2927 9011802 47.9 µM 0.960786255338256 0.146292482244373 no 474 0.168329825433526 791 43912568
SGTC_2038 4100038 30.985 µM 0.960623511813144 0.146333688566351 no 475 0.168370751207131 841 3596803
SGTC_2396 5342950 42.78 µM 0.959267228290158 0.146677399829719 no 476 0.168712070177971 840 1886677
SGTC_1035 k081-0041 55.2 µM 0.958051790899223 0.146985877572292 no 477 0.169018321695694 884 731709
SGTC_2696 st077691 74.316 µM 0.957936445554385 0.14701517478247 no 478 0.169047403588159 750 757133
SGTC_1008 4106-0037 6 µM 0.957094600001501 0.147229118430892 no 479 0.169259754477469 844 2905394
SGTC_1073 triclabendazole 3.09 µM 0.956805521946339 0.147302631816324 no 480 0.169332712299635 890 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1129 3453-1384 223 µM 0.956729559087208 0.147321953472071 no 481 0.169351887234083 880 1084452
SGTC_1803 st050068 52.4 µM 0.956292125421349 0.147433250670947 no 482 0.169462333601883 981 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1249 0481-0015 10.2 µM 0.956070502269345 0.147489660228746 no 483 0.169518308231197 799 4227577
SGTC_131 0141-0277 33.849 µM 0.952422536838438 0.148420251751441 no 484 0.170441367164455 848 1547771
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.950250758653698 0.148976130564342 no 485 0.170992426389811 680 4000243
SGTC_2939 9044578 71.43 µM 0.946433566006658 0.149956529228766 no 486 0.171963745931714 825 2653634
SGTC_2878 9043973 25.97 µM 0.944355438621318 0.1504920751816 no 487 0.172494022414868 834 6465167
SGTC_2158 5657123 3.6195 µM 0.944172780148154 0.150539208210678 no 488 0.172540681247835 864 2858827
SGTC_1727 st034309 9.9045 µM 0.942171570685136 0.151056242460586 no 489 0.173052403284461 933 870305
SGTC_2309 7664088 163.95 µM 0.941311083987243 0.15127892142037 no 490 0.173272732146234 918 704922
SGTC_3297 9117502 71.43 µM 0.940274041234353 0.1515475800036 no 491 0.173538505681125 881 7453720
SGTC_1847 st056231 15 µM 0.938732029045601 0.151947643199978 no 492 0.173934172281047 910 5393180
SGTC_2487 5918373 44.05 µM 0.937960061871308 0.152148187427288 no 493 0.174132467483546 927 2876279
SGTC_2741 miltefosine 3.04 µM 0.936057766407762 0.152643122005931 no 494 0.174621723141356 765 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1619 st003326 88.7 µM 0.93556699785807 0.152770982091603 no 495 0.174748086516911 838 2849032
SGTC_439 amiodarone 34.4 µM 0.934896057185814 0.152945897381551 no 496 0.174920934617161 867 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_184 1494-0393 24.714 µM 0.93485169955919 0.152957466162226 no 497 0.174932365875253 854 3090647
SGTC_2890 9046729 58.44 µM 0.933884946042675 0.153209746380494 no 498 0.175181622490342 808 903329
SGTC_249 wiskostatin 11.211 µM 0.93323862887393 0.153378560486871 no 499 0.175348387053396 882 2775510 A n-wasp and actin depolymerizer.
SGTC_2273 7815444 169.05 µM 0.932022641344711 0.153696502898434 no 500 0.175662412277713 854 2824616
SGTC_72 0744-0168 198.391 µM 0.928000404273427 0.154751297803846 no 501 0.176703679956419 840 677577
SGTC_1061 3448-9325 110 µM 0.927865617822192 0.154786726942746 no 502 0.176738640612369 870 723482
SGTC_1649 st011737 51.3 µM 0.927069662063762 0.154996056236216 no 503 0.176945183268022 868 1761035
SGTC_1789 tunicamycin 25 nM 0.926882229641368 0.155045376480146 no 504 0.176993842309122 879 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_808 0711-0032 135 µM 0.926512346300254 0.155142736555033 no 505 0.177089891954376 889 4252555
SGTC_1861 st057647 17.4 µM 0.926403389469062 0.155171423684279 no 506 0.177118191652452 885 688668
SGTC_1314 1222-0010 41.1 µM 0.919534935655122 0.156986879759222 no 507 0.178907920551857 895 3526027
SGTC_1729 st035615 45.989 µM 0.919187803619305 0.157079002447303 no 508 0.17899867468499 862 17385451
SGTC_2109 5483026 200 µM 0.919141751824557 0.15709122644796 no 509 0.179010716633442 889 759335
SGTC_2605 digitonin 300 nM 0.918532323408567 0.157253052211141 no 510 0.179170122283013 995 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1914 st062367 72.6 µM 0.916602364918625 0.157766250403335 no 511 0.179675522336402 853 978205
SGTC_717 1532-0246 73.2 µM 0.913707067444562 0.158538204085066 no 512 0.180435394696487 866 9561992
SGTC_2988 9073640 71.4286 µM 0.913063828722271 0.15871004224121 no 513 0.180604486349624 838 9102229
SGTC_2084 5306078 60.6385 µM 0.912885695703848 0.158757651209628 no 514 0.180651330707603 858 679340
SGTC_639 0833-0042 114 µM 0.911376468085196 0.159161392667595 no 515 0.18104852405516 926 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3230 9131665 49.47 µM 0.90933461470996 0.159708689195639 no 516 0.181586762152745 822 15943720
SGTC_2068 5226020 147 µM 0.908025592255115 0.160060205399198 no 517 0.181932350254685 952 1810509
SGTC_1513 0337-0559 19 µM 0.906801787327044 0.160389295065021 no 518 0.182255812283676 833 775073
SGTC_1844 rapamycin 4 nM 0.904403804088779 0.161035410479055 no 519 0.182890660891493 965 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.903694351374189 0.161226891414053 no 520 0.183078747575887 983 368090
SGTC_3065 9113888 49.47 µM 0.902401528083314 0.161576205569003 no 521 0.183421804834054 847 16648368
SGTC_2032 5185112 25.99 µM 0.901556443691416 0.161804809459164 no 522 0.183646268738032 862 5718189
SGTC_1811 st050069 61.5 µM 0.900731924336606 0.162028053326081 no 523 0.18386543522547 918 3877702
SGTC_789 1309-1135 70.6 µM 0.900566345916974 0.16207290891551 no 524 0.183909467459245 905 3092424
SGTC_3240 9133527 49.47 µM 0.899991234760293 0.162228770724087 no 525 0.184062457656957 883 17617455
SGTC_1151 3909-8316 15.3 µM 0.899934076142741 0.162244266703605 no 526 0.184077667233168 901 800431
SGTC_1003 4049-0218 100 µM 0.899740249272305 0.16229682128623 no 527 0.184129249262702 926 295161
SGTC_1088 bifonazole 369 nM 0.898465293955636 0.162642791233246 no 528 0.184468769979992 892 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_50 0929-0078 56.389 µM 0.897520319986414 0.162899527296197 no 529 0.184720667742341 860 1377751
SGTC_1426 4048-4480 71.7 µM 0.896858167488184 0.163079581690054 no 530 0.184897302323087 930 14224343
SGTC_3129 9127257 49.47 µM 0.895059984469433 0.163569201106339 no 531 0.185377511650368 774 837894
SGTC_1687 st020778 55.3625 µM 0.893275153935852 0.164056127768867 no 532 0.185854920079374 994 4259299
SGTC_598 3937-0236 20.2 µM 0.892881404634566 0.164163674544536 no 533 0.185960343147481 971 1379313
SGTC_2350 9023895 38.85 µM 0.891593494822287 0.164515767295541 no 534 0.186305429092513 898 2997209
SGTC_2481 5478948 45.16 µM 0.891523770173408 0.164534842790166 no 535 0.18632412261302 867 77792
SGTC_2167 5876490 200 µM 0.891335688053703 0.164586306052204 no 536 0.186374554147317 935 686534
SGTC_2025 5147754 141 µM 0.890606939312351 0.164785805679719 no 537 0.186570037560322 926 315777 YLR208W SEC13
SGTC_2563 tomatine 8.54 µM 0.890107990584801 0.164922486384329 no 538 0.186703951398842 938 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2360 9040895 200 µM 0.889831382134268 0.16499829140052 no 539 0.186778216520455 859 4914414
SGTC_748 act1.228 77.9 µM 0.889791503481859 0.165009222073473 no 540 0.186788924834125 936 4421505 YNR035C ARC35
SGTC_1684 st024538 14.6195 µM 0.888457766706119 0.165375067176986 no 541 0.18714728195387 927 6732859
SGTC_869 0564-0080 44.1 µM 0.887382938365332 0.165670275061149 no 542 0.187436383045568 891 6843321
SGTC_164 4100-3994 89.624 µM 0.886658324531457 0.165869486662458 no 543 0.187631441159015 983 4615967
SGTC_1310 1188-0297 994 nM 0.886549268411252 0.165899481885719 no 544 0.187660808726972 919 1588352
SGTC_705 1124-0212 310 µM 0.885644719398976 0.166148407717442 no 545 0.187904502889952 934 9554485
SGTC_2204 7233102 200 µM 0.883833516115097 0.166647563593483 no 546 0.188393045397885 874 2172480
SGTC_1386 3228-0095 33.8 µM 0.88317204660406 0.166830101311709 no 547 0.188571661133928 896 870181
SGTC_822 1487-0950 154 µM 0.883144272144119 0.166837768713235 no 548 0.188579163318023 941 1958375
SGTC_2918 7977171 22.06 µM 0.88221508525249 0.167094410528416 no 549 0.18883025286714 921 2236483
SGTC_1283 0922-0125 16.4 µM 0.881104289755356 0.167401546571057 no 550 0.189130687816172 982 3360884
SGTC_687 k029-0044 34.9 µM 0.88053294953348 0.167559664288202 no 551 0.189285331802203 984 5829338
SGTC_768 0384-0033 77.3 µM 0.874368663915658 0.169271738383561 no 552 0.19095875842847 928 3965305 YMR134W ERG29
SGTC_3085 9117376 49.47 µM 0.874128223130016 0.169338745390213 no 553 0.191024214558088 932 16480349
SGTC_2373 9071805 200 µM 0.873735137036195 0.169448328870322 no 554 0.191131255546531 964 10149009
SGTC_49 0717-0965 32.132 µM 0.87370047304756 0.169457994586468 no 555 0.191140696636365 1022 5889349 YGL099W LSG1
SGTC_2254 7938975 95.19 µM 0.873680502905599 0.169463563226984 no 556 0.191146135837438 1001 2969277
SGTC_3346 9158254 43.5805 µM 0.873016601312429 0.169648757910857 no 557 0.191327014521209 924 17639500
SGTC_3170 9103054 49.47 µM 0.872671705518617 0.169745017466752 no 558 0.191421022093191 886 16432970
SGTC_2358 9037157 4 µM 0.872634117619429 0.16975551027205 no 559 0.19143126906351 938 2388925
SGTC_863 0466-0191 129 µM 0.872390119881933 0.169823633284211 no 560 0.19149779432318 978 765160 YPR165W RHO1
SGTC_547 1120-0019 610 nM 0.871969748917868 0.169941039976176 no 561 0.191612440437295 916 3676939
SGTC_1645 Cervolide 78 µM 0.871357329663514 0.170112177523427 no 562 0.191779538343324 895 23173 A fragrance.
SGTC_2 0422-0095 29 µM 0.871094254013397 0.170185726620083 no 563 0.191851345626634 834 6790840
SGTC_2164 5685496 200 µM 0.866728493519396 0.171409253379258 no 564 0.193045394783523 967 759046
SGTC_673 1082-0474 110 µM 0.864222432940162 0.172114123314869 no 565 0.193732855591433 1047 3098046
SGTC_2407 paclitaxel 400 µM 0.863608656987443 0.172287039333522 no 566 0.193901453458073 958 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2807 7945238 51.95 µM 0.863204052856691 0.172401087018239 no 567 0.194012642889075 945 17148797
SGTC_2159 5658611 73.75 µM 0.863068561119965 0.172439289477415 no 568 0.194049886111474 998 793844
SGTC_2461 5755302 26.15 µM 0.86194646970961 0.172755875313083 no 569 0.194358487796443 966 2788904
SGTC_2986 9022445 71.43 µM 0.86067699868054 0.173114489066671 no 570 0.194707982384897 968 6459286
SGTC_3291 9121177 71.43 µM 0.860241236054605 0.173237697190731 no 571 0.194828039090466 864 17015612
SGTC_1525 8-methoxypsoralen 92.5 µM 0.860013548879161 0.173302095980514 no 572 0.194890786955239 1023 4114 Related to psoralen; DNA damaging agent.
SGTC_1295 1013-0063 9.78 µM 0.858295887550551 0.173788408537237 no 573 0.195364549848621 986 6826038
SGTC_352 k048-0007 5.11 µM 0.857430331411155 0.174033797553386 no 574 0.195603551183529 994 6811911
SGTC_720 r052-1644 49.9 µM 0.855882287204717 0.174473223959634 no 575 0.196031446695537 866 1422863 YOR257W CDC31
SGTC_2469 5655019 90.81 µM 0.855436356233363 0.174599936145116 no 576 0.196154811911879 1033 2788239
SGTC_212 3807-4682 38.772 µM 0.853937343054446 0.175026312011342 no 577 0.196569853582347 1102 3125501 YBL034C STU1
SGTC_1615 st002656 86.5 µM 0.851982437317181 0.175583352506133 no 578 0.197111919921711 955 1584458
SGTC_1824 st053723 68.6 µM 0.850236043570393 0.176081927591512 no 579 0.197596933160378 1006 675225
SGTC_156 3474-0145 5.642 µM 0.850169829065004 0.176100848679915 no 580 0.197615336616945 963 2265471
SGTC_3137 9097352 49.47 µM 0.849668086878976 0.176244265558852 no 581 0.197754822968818 1012 44120435
SGTC_2667 digitoxin 100 µM 0.84891193870717 0.176460540875923 no 582 0.197965147568198 942 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2050 5263056 171 µM 0.847275529362993 0.176929165120925 no 583 0.19842078147033 1014 763468 YGL055W OLE1
SGTC_1489 4065-0444 182 µM 0.846821085239202 0.177059445273766 no 584 0.198547426864986 959 2877968
SGTC_621 3584-0052 32.1 µM 0.846217403628069 0.177232602569823 no 585 0.198715737446468 1010 2273927
SGTC_21 0849-0113 22.993 µM 0.845328067216636 0.177487890551452 no 586 0.198963847218381 966 1560156
SGTC_2982 9019404 25.97 µM 0.844319022861763 0.177777822160172 no 587 0.199245579431848 914 22333232
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.843239343478181 0.178088380210321 no 588 0.199547299363006 944 17037758
SGTC_485 niflumic acid 177 µM 0.842979921334918 0.178163051104329 no 589 0.199619836681805 961 4488 A COX2 inhibitor.
SGTC_3311 9131146 2.8755 µM 0.841115578053264 0.178700255610817 no 590 0.200141594411372 962 4900406 YPR165W RHO1
SGTC_3004 9076122 71.4286 µM 0.840993973574531 0.178735330944411 no 591 0.200175655263699 983 44782551
SGTC_692 k241-0027 77.8 µM 0.840478632344259 0.178884022958747 no 592 0.200320038620514 976 3600480
SGTC_2965 9082772 38.63 µM 0.83965577353326 0.179121604733199 no 593 0.200550708971119 1021 16459634
SGTC_64 000l-0018 272.079 µM 0.839390843763317 0.179198139404534 no 594 0.200625010129696 1013 6811119
SGTC_3277 9138724 49.47 µM 0.837988985866256 0.179603459712815 no 595 0.201018444693411 873 15943418
SGTC_2418 pentamidine 31.67 µM 0.836465934693385 0.180044473181764 no 596 0.201446416568129 985 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2818 7996756 12.99 µM 0.835429153196729 0.180345071400752 no 597 0.201738060540031 956 2241621
SGTC_1571 st070080 73.4 µM 0.835398849515925 0.180353862202534 no 598 0.201746588689326 991 4315245
SGTC_2862 9027634 71.43 µM 0.833219913975922 0.180986654696714 no 599 0.202360356738419 908 5012562
SGTC_432 NS 1619 61.3 µM 0.830414408992114 0.181803457550413 no 600 0.203152260841347 921 4552 A K+/calcium channel activator.
SGTC_3149 9097855 49.47 µM 0.829362725596324 0.182110240995634 no 601 0.20344959342686 959 25236625 YMR079W SEC14
SGTC_855 0428-0020 25 µM 0.828992170188056 0.182218411671574 no 602 0.203554418902288 917 6812414
SGTC_1411 3909-8223 150 µM 0.827911132029584 0.182534212306817 no 603 0.203860415045705 1061 X1411
SGTC_1344 1488-0097 29.1 µM 0.826699688990398 0.182888513663134 no 604 0.204203648846096 978 747966
SGTC_2125 5246583 200 µM 0.826636883990632 0.182906893449486 no 605 0.204221452539373 1062 835267
SGTC_735 3076-0345 636 µM 0.823488418557471 0.183829763998739 no 606 0.205115150257147 1037 2888990
SGTC_2107 5363541 170.161 µM 0.822227520459661 0.18420016730712 no 607 0.20547370930282 1023 244052
SGTC_2321 7390090 138.78 µM 0.821948604924371 0.184282164647356 no 608 0.205553074192058 939 649046
SGTC_2056 5235370 200 µM 0.821402658872705 0.184442731024679 no 609 0.205708474777481 946 5511916
SGTC_3244 9134489 49.47 µM 0.820752880734727 0.184633948501367 no 610 0.205893521451909 998 16584271
SGTC_3063 1327-0034 4 µM 0.820251380462278 0.184781614843176 no 611 0.20603640839944 977 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_395 anisomycin 6.25 µM 0.820024336733088 0.184848491816514 no 612 0.206101116801253 954 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_794 k038-0031 316 µM 0.819822319703381 0.184908009684319 no 613 0.206158702619908 1031 6624242
SGTC_2648 atorvastatin 78.68 µM 0.818265593576539 0.185367048713103 no 614 0.206602773944491 1010 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2815 7968870 71.43 µM 0.817633657327794 0.185553592390726 no 615 0.206783201471228 1029 2977326 YHR190W ERG9
SGTC_2129 girgensonine 121.053 µM 0.815031887588225 0.186322845295637 no 616 0.20752702881013 1059 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_985 1493-0307 8.71 µM 0.814151468506113 0.18658360141907 no 617 0.207779091967033 994 3278274
SGTC_150 3970-0969 77.2 µM 0.813848840731263 0.186673283673391 no 618 0.207865775759147 1018 6615640
SGTC_3030 9087619 49.47 µM 0.812602658419815 0.187042864814657 no 619 0.208222953449849 1044 25236973
SGTC_3248 9135562 49.47 µM 0.812367135883476 0.187112764717849 no 620 0.208290499001973 1032 17650701
SGTC_1759 st043059 70 µM 0.81223162734594 0.187152989140197 no 621 0.208329367378211 1030 669426
SGTC_2831 7999036 19.48 µM 0.812097868928817 0.187192699300291 no 622 0.208367737957172 1038 2988270
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.811979115421445 0.187227959173318 no 623 0.208401807649071 1067 165521
SGTC_1719 st032227 49.2 µM 0.811285427454175 0.187434008613639 no 624 0.208600888341563 1053 3125804
SGTC_1354 1498-1681 81 µM 0.811100669078568 0.187488911901382 no 625 0.208653930830962 1050 5754243
SGTC_2277 7947813 106.88 µM 0.809689205473841 0.187908674086314 no 626 0.209059411793227 983 1246798
SGTC_938 3126-1755 342 µM 0.809542057997514 0.187952468382611 no 627 0.209101710565236 1064 1777771
SGTC_2946 9065502 71.43 µM 0.80949249244746 0.187967221589393 no 628 0.209115959731459 864 16489101
SGTC_2430 5571206 200 µM 0.80927315012628 0.188032517505451 no 629 0.209179023398892 1119 1731771
SGTC_1579 chlormadinone acetate 49.4 µM 0.805716204471851 0.18909333674351 no 630 0.210203251924031 1051 45114258 A steroidal progestin.
SGTC_959 1222-0044 107 µM 0.805118003680623 0.189272104824174 no 631 0.210375793732435 1042 6083612
SGTC_1349 flufenamic acid 69 µM 0.805107645880109 0.18927520109579 no 632 0.210378782012656 978 3371 A non-steroidal anti-inflammatory.
SGTC_1874 staurosporine 7.6 µM 0.800668391144901 0.190605103091599 no 633 0.211661823087465 1057 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_60 0986-0278 202 µM 0.800530375952923 0.19064654110312 no 634 0.211701785748576 926 3110598
SGTC_367 0335-0881 7.1 µM 0.800316416325268 0.190710791783641 no 635 0.211763747048846 1024 23828853
SGTC_422 cantharidin 155 µM 0.799874707049085 0.190843476228028 no 636 0.211891696711932 1011 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2016 5121758 140 µM 0.797792329907733 0.191469761223266 no 637 0.212495506533163 1097 2795203
SGTC_31 0508-1974 57.237 µM 0.797769676539315 0.191476581250112 no 638 0.212502080666511 1017 6810525
SGTC_1227 3909-8010 46.6 µM 0.797552010808869 0.191542119316507 no 639 0.212565254525673 996 15982272
SGTC_2715 st079500 56.4 µM 0.795732796954418 0.192090412779081 no 640 0.213093679901416 989 28246688
SGTC_1405 3909-7894 12 µM 0.794822095831031 0.192365249631257 no 641 0.213358497985166 1060 7104060
SGTC_2008 4012253 172 µM 0.794201889392749 0.192552556823546 no 642 0.213538954384792 1036 603940
SGTC_1208 2323-2347 50.3 µM 0.790847924456197 0.193567410740688 no 643 0.214516369956565 1063 5412760
SGTC_1094 duloxetine 25.4 µM 0.790331253263186 0.193724036309496 no 644 0.214667169615745 1048 60834 A selective serotonin reuptake inhibitor.
SGTC_718 1130-0073 349 µM 0.790326046544795 0.193725615086043 no 645 0.214668689602421 1070 6740020
SGTC_1557 sumaresinolic acid 42.3 µM 0.78944497195677 0.193992886710183 no 646 0.214925989978529 1008 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1698 5-fluorocytosine 1.055 µM 0.788374680743675 0.194317858767117 no 647 0.215238788144038 1073 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_815 1582-0027 36.9 µM 0.788053638608646 0.194415401240489 no 648 0.215332665861816 1063 3128206
SGTC_1458 k015-0034 6.33 µM 0.786169118370882 0.194988577241749 no 649 0.215884207756694 1040 3598957
SGTC_3282 9108498 15.4605 µM 0.785117589674927 0.195308845337016 no 650 0.216192313792113 1008 16459645
SGTC_2519 cryptotanshinone 88.04 µM 0.784966059125918 0.195355023905164 no 651 0.216236734394593 1058 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1718 roemerine 11.9335 µM 0.78395082046222 0.195664586490803 no 652 0.216534484013665 1027 235224 An aporphine alkaloid with mutagenic activity.
SGTC_722 3534-0461 190 µM 0.783479567630935 0.195808380194687 no 653 0.216672773810079 1085 658262
SGTC_7 0192-1582 4.227 µM 0.78316784556424 0.195903531397711 no 654 0.216764277145976 1104 252616
SGTC_2207 7258803 200 µM 0.782158842847944 0.196211715466417 no 655 0.217060614408937 1030 3666799
SGTC_3111 9122088 49.47 µM 0.78206592998771 0.196240109017318 no 656 0.217087914052378 975 16876704
SGTC_3040 9091894 49.47 µM 0.781155435524769 0.196518481858317 no 657 0.217355540362287 992 25236966
SGTC_933 2914-0560 114 µM 0.780528776255691 0.196710214409206 no 658 0.217539848169583 1123 463887
SGTC_1973 st070275 50.2 µM 0.780409110649392 0.196746840154737 no 659 0.217575053475921 1042 17118334
SGTC_3067 9117431 49.47 µM 0.779782016085865 0.196938840902561 no 660 0.217759596801827 1063 17150885
SGTC_1708 st033234 31.827 µM 0.777763588057807 0.197557603009068 no 661 0.218354198724954 1123 674664
SGTC_2947 9072639 7.68 µM 0.77679586203633 0.197854682005915 no 662 0.218639609248523 1127 16488146
SGTC_964 1287-0107 19.4 µM 0.776652375342966 0.197898753473153 no 663 0.21868194591752 1081 51516812 YPR165W RHO1
SGTC_2143 5623677 140.463 µM 0.776082433754288 0.19807386771296 no 664 0.218850157426163 1069 5375313
SGTC_2646 retinol 96.75 µM 0.775162480597449 0.198356720140126 no 665 0.21912182770124 1078 445354 A vitamin A analog and teratogen.
SGTC_3106 9121286 49.47 µM 0.774982551280855 0.198412070403053 no 666 0.219174985076164 1068 15943471
SGTC_1306 1185-0270 9.02 µM 0.774276593138971 0.198629328840238 no 667 0.219383621245423 1092 1548076
SGTC_102 gallobenzophenone 83.616 µM 0.774164355551965 0.198663883142423 no 668 0.219416802023417 1056 70837
SGTC_2721 ifenprodil 61.44 µM 0.774139354098889 0.198671580770233 no 669 0.21942419359123 1062 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2737 bleomycin 30.5 nM 0.773411871789608 0.198895642024232 no 670 0.219639333120281 1125 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_478 N-arachidonylglycine 10 µM 0.77046812870106 0.199803855528201 no 671 0.220511126851201 988 5283389
SGTC_1507 4075-3230 155 µM 0.77005937201172 0.199930163459547 no 672 0.220632337317905 1014 659771
SGTC_2586 curcumin 80 µM 0.769356925399155 0.200147335219324 no 673 0.22084072611325 1119 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2313 7726885 200 µM 0.767068806783304 0.20085572342719 no 674 0.221520303467673 1065 726423
SGTC_954 1189-0853 2.85 µM 0.762450776607915 0.202290013383956 no 675 0.222895505390931 1120 2828194
SGTC_2957 9076800 11.52 µM 0.76228666588267 0.202341096146361 no 676 0.222944465202362 1037 16459615
SGTC_1382 3002-2117 298 µM 0.761590849001006 0.202557768823384 no 677 0.223152119080858 1144 1497314
SGTC_1156 4092-0367 4.88 µM 0.761466427507227 0.202596527448564 no 678 0.223189262012141 1100 1357585
SGTC_2212 7123476 200 µM 0.761445871922637 0.202602931159515 no 679 0.223195398707567 1050 1085715
SGTC_2747 doxorubicin 7.63 µM 0.761159104085221 0.202692280974495 no 680 0.223281020829689 971 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2699 st077704 54.6 µM 0.761056292765887 0.202724320190063 no 681 0.223311722420142 1070 645852
SGTC_2565 isoliquiritigenin 100 µM 0.760717319589062 0.202829976245245 no 682 0.223412963851993 1009 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_541 4513-1321 94 µM 0.758707220615836 0.203457188558773 no 683 0.224013858286392 1044 747515
SGTC_317 4495-0002 170 µM 0.758538427561854 0.203509909756797 no 684 0.224064358653393 1034 15991618
SGTC_1886 st057356 49.9 µM 0.757740741944054 0.203759170885861 no 685 0.224303101781871 1062 24207747
SGTC_1980 st071811 45.7 µM 0.754291198413387 0.204839179142453 no 686 0.225337193105725 1116 4974850
SGTC_700 3453-2283 142 µM 0.753846528950691 0.204978646771734 no 687 0.225470690607366 1137 565664
SGTC_966 1300-0360 30.2 µM 0.752292722743934 0.205466430857696 no 688 0.22593752160822 1096 70588
SGTC_2765 myclobutanil 7.74 µM 0.752152488661282 0.205510488221927 no 689 0.225979680899231 1118 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_513 4245-1575 41.7 µM 0.75166085082145 0.20566499045837 no 690 0.226127519625161 1133 719745
SGTC_1871 st057448 67.3 µM 0.751528261949927 0.205706669672543 no 691 0.226167399325338 1158 691747
SGTC_2915 7971052 15.16 µM 0.749329246211072 0.206398659387466 no 692 0.226829392250694 990 5741558
SGTC_2055 5235184 200 µM 0.747536952537236 0.206963680081488 no 693 0.22736975291658 1092 2836034
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.746158615151096 0.207398822997548 no 694 0.227785802267326 1049 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3097 9117246 49.47 µM 0.745568649066683 0.207585241235803 no 695 0.227964013622177 1170 16423892
SGTC_595 3909-8003 73.7 µM 0.745053030414998 0.207748248131959 no 696 0.228119831018163 1127 699517
SGTC_1089 terbinafine 2.25 µM 0.74454058680492 0.207910326164096 no 697 0.228274748251326 1107 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3042 9091578 49.47 µM 0.743976475948785 0.208088832058548 no 698 0.228445353408757 1087 25236497
SGTC_2477 5967686 25.23 µM 0.743196991610279 0.208335639022691 no 699 0.22868121223608 1125 776118
SGTC_3215 9129942 49.47 µM 0.741440915616938 0.208892295059824 no 700 0.229213071942224 1067 17682944
SGTC_627 1391-0720 175 µM 0.740170503611973 0.209295546843296 no 701 0.229598271459581 1067 997839
SGTC_1825 st052143 62.6 µM 0.739020792264925 0.209660880691197 no 702 0.229947185911218 1111 674173
SGTC_1286 0929-0070 131 µM 0.738736984351328 0.209751121560394 no 703 0.230033361600261 1152 1420408
SGTC_1746 st038117 42 µM 0.73780066792204 0.210048998939794 no 704 0.230317793684452 1112 2898218
SGTC_2745 rifampicin 24.3 µM 0.737117438139851 0.210266516729866 no 705 0.230525467730493 1043 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2137 5261020 140 µM 0.736636036735556 0.210419858436751 no 706 0.230671856991015 1136 763655
SGTC_2545 solidagenone 89.61 µM 0.736489594065496 0.210466518118535 no 707 0.230716399014748 961 6708572 An anti ulcer agent
SGTC_1256 0570-0116 285 µM 0.735487298801632 0.210786033234275 no 708 0.231021386231585 1134 410638
SGTC_464 bw-b 70c 158 µM 0.735000981901513 0.210941165454682 no 709 0.231169448061848 1162 5353454
SGTC_1611 st001856 99.4 µM 0.733256024220793 0.21149834738287 no 710 0.231701145531437 1120 647478
SGTC_1805 st050013 60.3 µM 0.732855289269341 0.211626427516453 no 711 0.231823347652706 1085 4037144
SGTC_679 0422-0091 41.4 µM 0.730583944254593 0.212353236590922 no 712 0.232516660974399 1186 627384 YHR062C RPP1
SGTC_11 0438-0307 1.3 µM 0.730164714865934 0.212487545341639 no 713 0.232644753949705 1140 4011476
SGTC_2896 9052656 71.43 µM 0.729833891293393 0.212593566494392 no 714 0.232745862752582 1146 6469436
SGTC_779 1360-0071 233 µM 0.728710953317041 0.212953671970725 no 715 0.233089245611739 1219 7566
SGTC_2910 7948405 25.97 µM 0.728420480414213 0.213046879179106 no 716 0.233178115001181 1112 2971328
SGTC_1626 st003712 1.76 µM 0.727790556652688 0.213249091439607 no 717 0.233370903058054 1103 24207035
SGTC_1317 1273-0028 910 nM 0.726951799620916 0.213518515061556 no 718 0.233627741719037 1130 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2205 7238770 200 µM 0.726527100384355 0.213655011597918 no 719 0.233757850072161 1156 279867
SGTC_2089 5281248 129.67 µM 0.726288745430509 0.213731640136283 no 720 0.233830888681457 1153 2737878
SGTC_2295 7971645 200 µM 0.726019912195476 0.213818086318412 no 721 0.233913281860426 1119 2978226 YKL099C UTP11
SGTC_1707 st032323 6.317 µM 0.725209542748987 0.214078792383148 no 722 0.234161744710564 1100 3132057 YMR211W DML1
SGTC_585 0kpi-0023 191 µM 0.724572757401239 0.214283783994256 no 723 0.234357088395513 1104 64601
SGTC_2928 9011484 9.79 µM 0.723146441426203 0.214743352495967 no 724 0.234794959779949 1128 2994751
SGTC_525 k781-2675 26.7 µM 0.721912790236693 0.215141304613324 no 725 0.235174048554612 1204 3651118 YDL195W SEC31
SGTC_2289 7946404 165.07 µM 0.719425098859173 0.215945086709634 no 726 0.2359395184448 1210 1246120 YPR165W RHO1
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.718776429588475 0.216154959737974 no 727 0.236139341348401 1114 689007
SGTC_111 0083-0039 52.457 µM 0.7184265790391 0.216268200787691 no 728 0.236247151676822 1086 759313
SGTC_1381 2324-0066 62.1 µM 0.71782397395572 0.216463334963149 no 729 0.236432914657839 1132 10885928
SGTC_1627 st003713 25.6 µM 0.716711614816461 0.216823804000449 no 730 0.236776028840889 1206 16195070 YER133W GLC7
SGTC_3174 9107204 49.47 µM 0.716355479222703 0.21693928594447 no 731 0.23688593895001 1180 3938802
SGTC_1184 1269-1718 139 µM 0.714094465435153 0.2176732801266 no 732 0.237584384031754 1180 5403821
SGTC_1901 st060216 58.6 µM 0.713768653686269 0.217779166569404 no 733 0.237685122938288 1179 688792
SGTC_2086 5274770 176.623 µM 0.712214480358374 0.218284670298711 no 734 0.238165985738759 1161 689278
SGTC_1597 7-benzyloxygramine 47.5 µM 0.712132258694353 0.218311432178111 no 735 0.238191440042449 1178 260807
SGTC_2851 9015922 71.43 µM 0.711976421122326 0.218362160082528 no 736 0.238239688556704 1139 2996893
SGTC_2908 7930301 100 µM 0.711500289847033 0.218517191347733 no 737 0.23838713563548 1146 2223178
SGTC_1100 amiodarone 5.07 µM 0.710327347982138 0.218899378682439 no 738 0.238750582277192 1194 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_3069 9117009 49.47 µM 0.709483259085561 0.219174651476827 no 739 0.23901231831296 1055 41904981
SGTC_3105 9121040 49.47 µM 0.708937706058397 0.219352672103442 no 740 0.239181567433448 1026 41448907
SGTC_163 TUB2.036 7.546 µM 0.707812900796186 0.219719971963921 no 741 0.23953072693932 1212 15992207 YJR013W GPI14
SGTC_333 3486-0131 40.1 µM 0.705098947814718 0.220607652908282 no 742 0.240374330645913 1229 6744690
SGTC_2863 9028737 58.44 µM 0.704900163060736 0.220672752169249 no 743 0.240436184343515 1164 6460917
SGTC_110 0850-0284 111.64 µM 0.703985653718555 0.220972383064012 no 744 0.240720853948505 1058 3906265
SGTC_1514 1189-1591 158 µM 0.703318935166723 0.221190974192887 no 745 0.240928506483351 1190 767698 YMR146C TIF34
SGTC_1216 1165-0504 9.65 µM 0.703003493552754 0.221294438345511 no 746 0.241026786156715 1180 6304004
SGTC_1444 4112-3581 28 µM 0.70103297900538 0.221941388959633 no 747 0.241641217111005 1205 2877249
SGTC_2581 avocatin a 64 µM 0.700364574120171 0.222161081753842 no 748 0.241849827047385 1189 6710728 A skin care supplement.
SGTC_366 0181-0206 4.31 µM 0.700229696869543 0.222205428550952 no 749 0.24189193423855 1199 274874
SGTC_894 0960-0238 55.9 µM 0.700210282747502 0.222211812208823 no 750 0.24189799544092 1178 6741907 YDL195W SEC31
SGTC_1167 k781-0610 148 µM 0.700149673162502 0.222231742233262 no 751 0.241916918637747 1203 4525169
SGTC_1192 1488-0095 21.4 µM 0.6987599388144 0.222689003150266 no 752 0.242351034214386 1173 915875
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.696983338708283 0.223274333785348 no 753 0.242906610402117 1192 2374 Ca(2+)-ATPase inhibitor.
SGTC_2462 5162487 171.77 µM 0.696649169063051 0.223384529328983 no 754 0.243011188464653 1178 2259986
SGTC_2439 5492030 7.2 µM 0.69553406498686 0.223752469095647 no 755 0.243360335344161 1164 5722370
SGTC_987 1497-1013 404 µM 0.695393411986544 0.223798903419157 no 756 0.243404394026157 1179 1676435
SGTC_292 k038-0015 474 µM 0.694693266493181 0.224030126659601 no 757 0.243623774379283 1190 46368540
SGTC_1486 3970-0793 4.53 µM 0.694539684766871 0.224080865210613 no 758 0.243671911243263 1219 2844330
SGTC_2041 5107442 45.335 µM 0.6935200025441 0.224417901494925 no 759 0.243991638734734 1212 793005
SGTC_3322 9139058 2.11 µM 0.692711423192011 0.224685366201974 no 760 0.244245334450239 1226 4908926 YPR165W RHO1
SGTC_1908 st060353 56.5 µM 0.691906322193863 0.224951859865501 no 761 0.244498080037341 1224 4227716
SGTC_857 0438-0306 1.35 µM 0.689494398519671 0.225751293656335 no 762 0.245256098512791 1225 4686136
SGTC_2370 9071495 200 µM 0.688612389374883 0.226044037014275 no 763 0.245533611181212 1159 21791103
SGTC_2967 9089538 49.85 µM 0.687692096905937 0.226349715424519 no 764 0.245823348934225 1220 728216
SGTC_3144 9087057 49.47 µM 0.685704868711169 0.22701057608189 no 765 0.246449617975097 1151 17249618
SGTC_1005 4092-0690 4.4 µM 0.684022076603635 0.227571045034906 no 766 0.246980612695093 1200 1529343
SGTC_3199 9111318 49.47 µM 0.683786041373949 0.227649720940583 no 767 0.247055141087344 1164 8548020
SGTC_1829 berberine 14.4 µM 0.683013399910177 0.22790736697334 no 768 0.247299187636196 1222 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1664 st014217 9.02 µM 0.681772046716918 0.228321653552944 no 769 0.247691551199172 1271 3982782
SGTC_3236 9132701 49.47 µM 0.680978222720463 0.228586804408346 no 770 0.247942635108999 1193 24282524
SGTC_622 1348-1566 26.3 µM 0.680289445079968 0.228817008037906 no 771 0.248160603212815 1238 7340407
SGTC_1013 4112-3890 241 µM 0.680154121105276 0.228862251379076 no 772 0.24820343936166 1161 705171
SGTC_2157 5649910 96.377 µM 0.679959635862752 0.228927283107836 no 773 0.248265009628524 1197 2858091
SGTC_2413 inermin 26.06 µM 0.679435329353344 0.229102651703394 no 774 0.248431035492222 1276 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2337 9009472 200 µM 0.677346521390509 0.229802058024174 no 775 0.249093060329901 1255 5742383
SGTC_1123 mangostin 811.285 nM 0.676874144822678 0.229960391892653 no 776 0.249242904927471 1196 5281650 An antioxidant.
SGTC_2474 5321570 43.32 µM 0.67676731563813 0.229996207971066 no 777 0.249276799315942 1226 2841384
SGTC_483 fpl-64176 144 µM 0.675020434378534 0.230582318697279 no 778 0.249831391185045 1241 3423
SGTC_1636 st007707 68.9 µM 0.674490759476595 0.23076019911598 no 779 0.249999679274407 1253 403051
SGTC_2163 5671233 125 µM 0.674268564640457 0.230834841494969 no 780 0.250070292830492 1278 701023
SGTC_377 3970-0964 33.1 µM 0.674251002639189 0.230840741709935 no 781 0.250075874488621 1228 16481235
SGTC_2739 tacrine 100.86 µM 0.674142475253128 0.230877204964231 no 782 0.250110368764453 1237 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_346 4513-0042 7.16 µM 0.673293454797154 0.231162571572536 no 783 0.25038030797362 1232 2827372
SGTC_2711 st079103 59.1 µM 0.671951383284835 0.231614060106405 no 784 0.25080732358381 1227 54693780
SGTC_732 3970-1727 52.7 µM 0.670865779781528 0.231979629083639 no 785 0.251153018981469 1237 1275699
SGTC_430 0958-0115 16.4 µM 0.670470190036036 0.232112920839607 no 786 0.251279051677831 1222 6833180
SGTC_2980 9014342 25.29 µM 0.670105170937762 0.232235949793812 no 787 0.251395374392643 1243 2996599
SGTC_2640 pentamidine 10.38 µM 0.669000363569512 0.232608543933481 no 788 0.251747623020727 1252 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2485 5633444 17.78 µM 0.668868447364763 0.232653054615435 no 789 0.251789699620255 1222 5724239
SGTC_932 2857-0803 154 µM 0.667788069154569 0.233017769979628 no 790 0.252134441707043 1322 674898
SGTC_2898 9056270 58.44 µM 0.666985844814268 0.233288791112845 no 791 0.252390587573116 1179 19154699
SGTC_2593 nobiletin 86.24 µM 0.664529161750698 0.23411983687159 no 792 0.253175845451351 1202 72344 An anti-infammatory.
SGTC_2517 totarol 10 µM 0.663671346994772 0.234410403791058 no 793 0.253450341001405 1208 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_54 0159-0055 9 µM 0.663624977645545 0.234426116127161 no 794 0.25346518336785 1306 3319099
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.66340491681955 0.23450069207257 no 795 0.253535628871498 1252 5377381
SGTC_2505 galangin 7.89 µM 0.661552076023601 0.235129117527262 no 796 0.254129164838122 1185 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_10 0279-0212 42.575 µM 0.659457810899961 0.235840544956257 no 797 0.254800914650451 1266 39851 YBR002C RER2
SGTC_245 methotrexate 289.6 µM 0.657678012070927 0.236446078932471 no 798 0.255372527064869 1266 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_871 0574-0004 149 µM 0.657168058004335 0.236619736196461 no 799 0.255536430852241 1244 9551173
SGTC_3194 9111903 49.47 µM 0.657068360479086 0.236653694902418 no 800 0.255568480947347 1278 17087251
SGTC_278 4092-0821 23.9 µM 0.656318691017448 0.236909131177715 no 801 0.255809546922456 1253 877900
SGTC_1451 4152-0210 104 µM 0.656103475549481 0.236982489938451 no 802 0.255878774179685 1263 659563
SGTC_382 3229-0966 23.2 µM 0.655764631780038 0.237098014180401 no 803 0.25598778813089 1286 5722370
SGTC_1201 1889-3372 45.9 µM 0.654735057492802 0.237449223517254 no 804 0.256319174821992 1196 5392199
SGTC_2101 5377231 179.231 µM 0.654362624276336 0.237576338587073 no 805 0.256439104086678 1271 2844213
SGTC_608 k048-0125 159 µM 0.653884805888935 0.237739477313641 no 806 0.256593011815854 1283 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_770 0389-1121 67.2 µM 0.650454935147139 0.238912319752916 no 807 0.257699201055219 1338 6753108
SGTC_844 0330-0132 15.3 µM 0.649396753685938 0.239274801973783 no 808 0.258040980882327 1255 2828079
SGTC_1196 1588-0294 184 µM 0.648087936437164 0.239723555322131 no 809 0.258464038023381 1256 6144269
SGTC_2837 9008476 45.46 µM 0.648044807353776 0.239738350776034 no 810 0.258477985017556 1293 2992805
SGTC_75 0159-0059 199.013 µM 0.647716643624511 0.239850943827286 no 811 0.258584118694771 1378 5377270
SGTC_2744 captopril 92.04 µM 0.647630594058591 0.239880472226009 no 812 0.258611952307644 1262 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2024 5144227 134 µM 0.647087709895527 0.240066811728297 no 813 0.258787589505792 1267 3475211
SGTC_786 4544-0069 423 µM 0.646747678206808 0.240183564349885 no 814 0.258897630066104 1313 748821 YLR208W SEC13
SGTC_2536 dehydroabietamide 32.04 µM 0.646665483283457 0.240211791283142 no 815 0.258924233500132 1317 3983547
SGTC_931 2812-0076 566 µM 0.645893860856486 0.240476865784139 no 816 0.259174047862432 1296 3450959
SGTC_2748 diazoxide 86.69 µM 0.644904496826701 0.240816973726405 no 817 0.259494538715224 1245 3019 A potassium channel activatior.
SGTC_3329 9141233 27.5565 µM 0.643682881519251 0.241237282176277 no 818 0.259890546367879 1277 4909101 YNL103W MET4
SGTC_1397 3532-0190 20.1 µM 0.643419563883185 0.241327931333615 no 819 0.259975946139121 1222 5322280
SGTC_2182 6325192 200 µM 0.642858827679933 0.241521030817231 no 820 0.260157853584443 1223 736248
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.642708140460532 0.241572936941695 no 821 0.260206748942091 1268 16486 A toxic proline analog.
SGTC_1752 st044819 83.042 µM 0.642706876038233 0.241573372513623 no 822 0.260207159244969 1224 441209 YML126C ERG13
SGTC_470 aa-861 153 µM 0.642503291504354 0.241643509476755 no 823 0.260273226427237 1241 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3152 9099253 49.47 µM 0.64207955682105 0.241789525871339 no 824 0.260410764371604 1282 25236131
SGTC_604 1000-0114 314 µM 0.641089384401171 0.242130919859293 no 825 0.260732305420797 1332 1572745
SGTC_1417 3966-0327 90.4 µM 0.640662463653983 0.242278195197107 no 826 0.260871003416905 1327 651118
SGTC_1950 st077106 7.18 µM 0.640158909965936 0.242451969072884 no 827 0.261034646686428 1258 13831864
SGTC_384 k007-0144 5.16 µM 0.639737478532939 0.242597454850314 no 828 0.261171642683532 1289 6824886
SGTC_3019 9081971 49.47 µM 0.636679285617845 0.243654613347545 no 829 0.262166884496991 1331 16451803
SGTC_2520 obtusaquinone 4.71 µM 0.636421158310106 0.243743956692659 no 830 0.262250976903919 1349 5967872
SGTC_3242 9133940 49.47 µM 0.63630423233316 0.243784433076469 no 831 0.262289073456148 1327 17248444
SGTC_2825 7998094 58.44 µM 0.634284691899909 0.244484111588638 no 832 0.262947522472891 1280 2987815
SGTC_1962 st076595 64.5 µM 0.632929471993744 0.244954239280671 no 833 0.263389850374714 1316 279619
SGTC_362 0310-0100 9.03 µM 0.632716595492504 0.24502813061732 no 834 0.263459365277685 1317 790235
SGTC_127 0180-0333 59.125 µM 0.632520594280544 0.245096174991347 no 835 0.263523377828154 1258 771601
SGTC_435 c-PAF 6.7 µM 0.632246370417893 0.245191392431664 no 836 0.263612950638711 1255 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2717 st081029 62.2815 µM 0.631749822311374 0.245363857060211 no 837 0.263775183226684 1269 5292846
SGTC_2888 9058547 12.99 µM 0.630455388735098 0.24581375531007 no 838 0.26419834081592 1227 16476514
SGTC_578 3460-0051 92 µM 0.63017654518837 0.245910729169976 no 839 0.264289541574595 1352 2876744
SGTC_2456 5770359 74.46 µM 0.626835917547615 0.247074099163052 no 840 0.265383398429443 1329 3118787
SGTC_965 1291-5240 308 µM 0.625234071380774 0.247632982957948 no 841 0.265908721576774 1333 2834598
SGTC_2444 5485484 36.41 µM 0.625166145338353 0.247656697254793 no 842 0.265931009464526 1379 6790631
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.6244051100036 0.247922472328629 no 843 0.266180785011028 1276 77254
SGTC_888 0916-0002 6.97 µM 0.621084043927812 0.2490840619066 no 844 0.267272163558862 1357 2802138 YIL048W NEO1
SGTC_2874 9043904 71.43 µM 0.620679268248622 0.249225835575481 no 845 0.267405336352102 1285 4463428
SGTC_2823 7987624 58.44 µM 0.62025169865914 0.249375639458594 no 846 0.26754604477289 1340 2239440
SGTC_1251 0490-5699 265 µM 0.619411927887047 0.249670001991468 no 847 0.267822512660275 1344 3883818
SGTC_3168 9103419 49.47 µM 0.618938407988438 0.24983606494708 no 848 0.267978467496351 1264 16649256
SGTC_1375 2910-0797 186 µM 0.615105582674907 0.251182388329512 no 849 0.269242497746325 1329 742508
SGTC_1339 1486-1321 22.7 µM 0.614603319119447 0.251359098024505 no 850 0.2694083609634 1320 3469382
SGTC_1828 st055811 49 µM 0.614177020670716 0.251509132715055 no 851 0.269549178291705 1285 5877589
SGTC_88 0180-0332 8.668 µM 0.61414079626205 0.251521883987584 no 852 0.269561145844436 1352 3101745
SGTC_2855 9016525 58.44 µM 0.612908008804024 0.251956038265167 no 853 0.269968583708994 1303 43811474
SGTC_1149 3909-7961 23.3 µM 0.61211807173868 0.252234440412134 no 854 0.270229820859255 1288 735261
SGTC_2054 5233173 129 µM 0.611707465232398 0.252379216916324 no 855 0.270365660923367 1353 6889
SGTC_910 3454-3003 490 µM 0.610942405162948 0.252649087649144 no 856 0.270618855106406 1289 820824
SGTC_672 1441-0018 53.7 µM 0.609398080396292 0.253194302433687 no 857 0.271130304984934 1288 251141
SGTC_1946 st076057 65.1 µM 0.607528106364879 0.253855313062523 no 858 0.271750247979672 1236 953009
SGTC_1141 3253-0389 52.6 µM 0.606100423954702 0.254360588680275 no 859 0.272224034742616 1305 5402031
SGTC_2126 5251174 33.877 µM 0.605589007750295 0.254541713765193 no 860 0.272393851727689 1398 790722
SGTC_2768 sulfasalazine 50.2 µM 0.604240405985341 0.255019663452212 no 861 0.272841910370277 1421 5384001 An antioxidant and salicylic acid derivative.
SGTC_2201 6605497 169.863 µM 0.602900494456252 0.255494997854219 no 862 0.273287443514856 1345 670741
SGTC_1508 1080-0625 72.9 µM 0.6015340115177 0.255980234798443 no 863 0.273742182741817 1292 767111
SGTC_1779 st039427 55 µM 0.601188480175024 0.256103008803992 no 864 0.273857228177769 1465 1124498
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.600864337275749 0.256218210992094 no 865 0.27396517401106 1317 279621
SGTC_1726 st035556 14.5795 µM 0.600260863621897 0.256432760835687 no 866 0.274166198376652 1439 5919439
SGTC_593 1203-0218 61.7 µM 0.599507479460561 0.256700738902559 no 867 0.274417261956732 1383 3666956
SGTC_2074 5212007 75.395 µM 0.598678695300761 0.256995705015728 no 868 0.27469358342938 1282 758611
SGTC_1132 3456-3614 2.5 µM 0.597671581734626 0.25735437611952 no 869 0.275029545528896 1464 3125502
SGTC_3232 9132874 49.47 µM 0.594385712067769 0.258526404520327 no 870 0.276127081299724 1301 3784940
SGTC_3326 9140064 16.379 µM 0.592535077159276 0.259187717533129 no 871 0.276746169534964 1317 1868434
SGTC_3064 1327-0027 10 µM 0.590751584650764 0.259825864034995 no 872 0.277343439533195 1268 16000455 YPR107C YTH1
SGTC_2172 5754775 163.918 µM 0.590591742031597 0.259883096435165 no 873 0.277396999647776 1274 2263357
SGTC_1617 st002906 78 µM 0.590552780793003 0.259897047675252 no 874 0.277410055558215 1353 5150859
SGTC_2891 9063876 19.48 µM 0.590275779585539 0.259996247402205 no 875 0.277502887317864 1330 6472478
SGTC_1085 doxorubicin 7.67 µM 0.590045271460217 0.260078811899764 no 876 0.277580149365115 1387 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2475 5812728 15.03 µM 0.589525103234112 0.260265177888837 no 877 0.277754538715766 1342 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2308 7584454 197.62 µM 0.589453201895627 0.260290944128852 no 878 0.277778648255859 1428 893577
SGTC_729 4092-0585 94.1 µM 0.588693533186651 0.260563255865972 no 879 0.27803343838006 1322 2169061
SGTC_416 estradiol valerate 100 µM 0.587489308582381 0.260995223962504 no 880 0.278437564426112 1359 13791 A steroid.
SGTC_1014 4130-3005 69.3 µM 0.58745931770554 0.261005986704544 no 881 0.278447632723981 1337 743608
SGTC_829 1635-0120 117 µM 0.586613851105713 0.261309490802997 no 882 0.278731538990343 1404 285054
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.586434620862137 0.261373853839897 no 883 0.278791742303249 1470 6728940
SGTC_2588 indole-3-carbinol 100 µM 0.583591187647964 0.26239604194169 no 884 0.27974769523323 1405 3712 Induces cell cycle arrest.
SGTC_1568 digitonin 820 nM 0.582753427868947 0.262697598805674 no 885 0.280029650344037 1456 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_221 trifluoperazine 10.304 µM 0.58269442375268 0.262718844387281 no 886 0.280049513868108 1343 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_3213 9129884 49.47 µM 0.582172220321554 0.262906912212846 no 887 0.280225341543578 1276 17190742
SGTC_2886 9058944 51.95 µM 0.581699430399204 0.263077243468406 no 888 0.280384577636055 1257 4949929
SGTC_2899 9053889 58.44 µM 0.581445042239573 0.263168914805226 no 889 0.280470273933418 1350 6470052
SGTC_2437 5741531 144.16 µM 0.579856484990209 0.263741736326768 no 890 0.28100570129537 1477 2262990
SGTC_940 3232-1287 54.8 µM 0.579768325317141 0.263773544640608 no 891 0.281035430202931 1345 1585493 YIL048W NEO1
SGTC_2231 micatex 6.853 µM 0.579415829528015 0.263900745881934 no 892 0.281154312826727 1378 20737 An antifungal of unknown mechanism.
SGTC_615 k087-0205 167 µM 0.579312100888228 0.263938183238219 no 893 0.28118930094132 1312 9642773
SGTC_2333 9017922 200 µM 0.5775065975846 0.264590252143293 no 894 0.281798641523262 1472 3163164
SGTC_220 paclitaxel 373.376 µM 0.576806204140096 0.264843424088386 no 895 0.282035189000773 1391 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_864 0469-0573 172 µM 0.576259827579453 0.265041008855207 no 896 0.282219785933997 1333 689425
SGTC_2435 5706476 10.6 µM 0.576055661060581 0.26511486028964 no 897 0.282288779863487 1403 5725375
SGTC_424 splitomicin 100 mM 0.575090395971666 0.265464158958623 no 898 0.282615081445658 1335 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1505 k297-0037 20.6 µM 0.569911302641285 0.267342286660154 no 899 0.284368929237525 1355 4089396
SGTC_2027 5150920 200 µM 0.569131002206251 0.267625831971831 no 900 0.284633620287517 1385 786715
SGTC_759 3486-0358 89.3 µM 0.568833669119149 0.267733916642556 no 901 0.28473451162094 1430 875103
SGTC_2913 7966556 36.57 µM 0.566869041703374 0.26844863814353 no 902 0.285401579409611 1407 2976516
SGTC_176 1486-1328 72.834 µM 0.56684314514191 0.268458065583505 no 903 0.285410377271716 1360 22310231
SGTC_293 4049-0273 38.5 µM 0.566078875661456 0.268736366817065 no 904 0.285670081360342 1332 1380311
SGTC_343 4130-2827 29.8 µM 0.564888025921756 0.26917029172596 no 905 0.286074964328687 1382 1118244
SGTC_2879 9041815 71.43 µM 0.563761634597422 0.269581052345984 no 906 0.286458182496975 1355 4942971
SGTC_1801 st050089 28.441 µM 0.563602371304308 0.269639156153452 no 907 0.286512386324802 1393 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_925 2064-1272 59.6 µM 0.563593686507291 0.269642324796342 no 908 0.286515342257176 1375 6815817
SGTC_2976 9009005 19.48 µM 0.563525570666639 0.2696671774661 no 909 0.286538526469274 1479 2993148
SGTC_2208 7283366 200 µM 0.562958032406861 0.269874293442088 no 910 0.286731730920179 1440 898663
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.561561026349678 0.270384452323926 no 911 0.287207570232031 1365 140250 A respiratory chain inhibitor.
SGTC_453 enantio-paf c16 10 µM 0.560836874833261 0.270649087639867 no 912 0.287454373113693 1368 13871343 A lipid and platelet activating factor
SGTC_446 go6976 132 µM 0.560789161681943 0.270666528566285 no 913 0.287470638070671 1394 3501 A protein kinase C inhibitor.
SGTC_2217 6934799 96.0675 µM 0.560711859009718 0.270694786751273 no 914 0.287496990736075 1392 675606
SGTC_2787 5284540 71.43 µM 0.560286137288655 0.270850436781803 no 915 0.287642140751107 1420 736958
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.560246743884538 0.270864841838811 no 916 0.287655573700767 1366 688662
SGTC_1618 st003135 44.5 µM 0.558197766183907 0.271614621940189 no 917 0.288354673038664 1371 1270615
SGTC_3231 9132313 49.47 µM 0.556134692183994 0.272370602926762 no 918 0.289059390263982 1426 4905967
SGTC_479 n-linoleoylglycine 10 µM 0.554671497208501 0.272907400468411 no 919 0.289559687687928 1400 6433346 An anti-infammatory.
SGTC_304 1310-0298 97 µM 0.553978648019991 0.273161766682404 no 920 0.289796729290542 1350 1550234
SGTC_1472 k841-0093 193 µM 0.551357651982545 0.274125076321727 no 921 0.290694262316536 1467 X1472
SGTC_3298 9116858 71.43 µM 0.54809391200866 0.275326958567989 no 922 0.291813710318536 1482 2506942
SGTC_3260 9137109 49.47 µM 0.547199753240589 0.275656687271089 no 923 0.292120752847604 1396 17478346
SGTC_1892 st058411 7.36 µM 0.544902020716531 0.276504885181748 no 924 0.292910453208378 1482 3934738
SGTC_1454 4239-0054 42.6 µM 0.544296218112981 0.276728727539036 no 925 0.293118824501592 1520 1340767
SGTC_2839 9003951 25.97 µM 0.543251775173247 0.277114854627208 no 926 0.293478231449206 1424 2990634
SGTC_151 3013-0144 2.285 µM 0.542876550394056 0.277253638326379 no 927 0.293607401192357 1496 906558 YHR107C CDC12
SGTC_1445 4239-0156 97.7 µM 0.542591203931471 0.277359201649891 no 928 0.293705648272714 1556 4008346
SGTC_752 1896-0090 130 µM 0.541269826969891 0.277848298339924 no 929 0.294160807222533 1424 772567
SGTC_3048 9093155 49.47 µM 0.539864382934362 0.278368973412135 no 930 0.294645281133441 1397 25236002
SGTC_647 0140-0236 81 µM 0.539536753114561 0.278490418796121 no 931 0.294758272056088 1466 990837
SGTC_161 4065-0411 162.148 µM 0.539261643126279 0.278592416132604 no 932 0.294853165696727 1480 1906281 YLR208W SEC13
SGTC_1910 st062352 60.4 µM 0.537029977833045 0.279420480256481 no 933 0.295623453500955 1332 2245730
SGTC_2401 5128683 200 µM 0.536222041793076 0.279720561101038 no 934 0.2959025508402 1353 708373
SGTC_2174 5790901 200 µM 0.534478096123278 0.280368824016875 no 935 0.296505399978129 1425 786020
SGTC_232 clozapine 119 µM 0.534266372541733 0.280447575816747 no 936 0.296578627123185 1433 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1097 itavastatin 7.23 µM 0.53126116965147 0.28156653143558 no 937 0.297618904787744 1440 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3049 9092223 49.47 µM 0.530721343620018 0.281767757879959 no 938 0.29780594666315 1436 8623917
SGTC_872 0588-0139 234 µM 0.53060773403255 0.281810116005216 no 939 0.297845317562155 1426 2047100
SGTC_3313 9133968 57.047 µM 0.529974793826645 0.282046157180168 no 940 0.298064703619924 1403 1494643
SGTC_875 0709-0210 25.7 µM 0.529524027558223 0.282214318604982 no 941 0.29822099048464 1465 6251364
SGTC_2769 toremifene 3.73 µM 0.529476648487086 0.282231996492158 no 942 0.298237419627422 1460 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2269 7935389 174.42 µM 0.528532636808162 0.282584333354599 no 943 0.298564850521347 1403 97605
SGTC_1655 st012546 55.1 µM 0.527312047958312 0.283040211305918 no 944 0.298988454542852 1411 720985 YLR208W SEC13
SGTC_2415 st077333 57.7 µM 0.527274862736977 0.283054105160071 no 945 0.2990013639164 1653 2766255
SGTC_3089 9117425 49.47 µM 0.527246832278549 0.283064578652851 no 946 0.299011095252322 1377 9401657
SGTC_1235 benzylparaben 21.5 µM 0.526613995826134 0.283301085494246 no 947 0.299230835387373 1417 7180
SGTC_1400 3771-8998 51.5 µM 0.523459686604316 0.284481341118322 no 948 0.300327198947632 1476 670767
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.522386548843494 0.284883414513677 no 949 0.300700609787649 1487 5393153
SGTC_357 1325-0123 420 µM 0.52117738253301 0.28533677839265 no 950 0.301121604222252 1478 1098503
SGTC_2954 9074818 52.69 µM 0.521076015659033 0.285374800416826 no 951 0.301156909105831 1492 16648742
SGTC_2551 apiole 73.87 µM 0.520230220318502 0.285692146516908 no 952 0.301451562292554 1408 10659 A possible DNA adduct former.
SGTC_2014 4013930 200 µM 0.518232563973188 0.286442341722282 no 953 0.302148008579086 1427 64556
SGTC_785 1270-0111 65.3 µM 0.518150660242833 0.28647311959752 no 954 0.302176578222375 1421 6741994
SGTC_899 1083-0020 478 µM 0.517140555411723 0.28685282687161 no 955 0.302529022434288 1519 767123
SGTC_650 1328-0195 38 µM 0.516891892451063 0.2869463380325 no 956 0.302615813786248 1453 2780821
SGTC_2324 6149169 200 µM 0.515067194863751 0.28763296764642 no 957 0.30325303283176 1431 2888231
SGTC_3176 9106582 49.47 µM 0.514835401580869 0.287720246498799 no 958 0.303334022370728 1409 17018027
SGTC_2381 9035592 200 µM 0.513171062407957 0.28834729973962 no 959 0.303915833078882 1392 4749657
SGTC_360 0957-0399 1.01 µM 0.512232697808617 0.288701120007953 no 960 0.304244080744959 1555 6752301 YPR165W RHO1
SGTC_1204 4049-0315 18.3 µM 0.511938760357248 0.288811994262149 no 961 0.304346934956272 1566 588402
SGTC_1178 0988-0033 191 µM 0.511859107414577 0.288842043087514 no 962 0.30437480967636 1483 5392207
SGTC_3039 9090270 49.47 µM 0.509172279212224 0.289856501627074 no 963 0.305315735940816 1502 17173750
SGTC_269 exalamide 29 µM 0.509027654904579 0.289911154407246 no 964 0.305366419900129 1498 3316 A derivative of salicylamide.
SGTC_1949 st076024 69.1 µM 0.507793479336126 0.290377739458887 no 965 0.305799091598305 1429 2921930
SGTC_766 1391-0721 126 µM 0.506837480262093 0.290739400244421 no 966 0.306134427890286 1576 1020919 YIL115C NUP159
SGTC_979 1426-2828 121 µM 0.506228816699313 0.290969771397018 no 967 0.306348013815785 1552 747872
SGTC_1621 st003705 32.4 µM 0.505226341735145 0.291349380794727 no 968 0.306699935417683 1565 24207032
SGTC_2175 5807670 165.306 µM 0.505196675789465 0.29136061798344 no 969 0.306710352447093 1441 241186
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.504517904565134 0.291617785544933 no 970 0.306948741770843 1429 6312947
SGTC_797 k781-0471 270 µM 0.503945552763853 0.291834715945597 no 971 0.307149819285354 1531 23738129
SGTC_1140 3229-1848 2.98 µM 0.503504150981949 0.292002065540862 no 972 0.307304931315083 1520 2849525
SGTC_1509 1326-1131 80 µM 0.502576661250535 0.292353852191317 no 973 0.307630970749362 1458 768313
SGTC_1855 st056195 39.6 µM 0.500157896260877 0.293272189021297 no 974 0.308481951121835 1547 4028379
SGTC_2906 7926292 26.41 µM 0.499771023558512 0.293419197618516 no 975 0.308618158005867 1466 2966319
SGTC_152 4469-0003 551.229 µM 0.496975519417079 0.294482480476791 no 976 0.309603157379352 1499 697280
SGTC_2606 farnesol 9.78 µM 0.496667687746825 0.294599674283089 no 977 0.30971170605755 1557 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_273 hydroxyurea 18.1 mM 0.496443495251996 0.294685039572758 no 978 0.309790772043754 1510 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3283 9109332 35.8195 µM 0.496036241227678 0.294840137981675 no 979 0.309934420866097 1433 17027281
SGTC_3349 9149703 23.001 µM 0.4951205910945 0.295188991034445 no 980 0.310257499841165 1444 4910494
SGTC_655 k060-0012 42 µM 0.494051885649537 0.295596396708941 no 981 0.310634768285393 1447 5994525
SGTC_1831 st055328 12 µM 0.491252198038581 0.296664900973056 no 982 0.311624042269515 1576 1103068
SGTC_2200 6600604 21.907 µM 0.490995043474762 0.29676313296688 no 983 0.311714976597822 1448 2904777
SGTC_80 0159-0065 512.242 µM 0.490298312688491 0.29702935608214 no 984 0.311961410413167 1492 1548079
SGTC_2762 leflunomide 42.06 µM 0.489936918538916 0.297167488980132 no 985 0.312089268763599 1523 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1072 oxiconazole 14.9 nM 0.489101243369843 0.297487015062252 no 986 0.312385010618857 1522 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1958 st076513 41.9 µM 0.489054380256902 0.297504938136586 no 987 0.312401598854954 1444 732122 YGL099W LSG1
SGTC_159 3970-0959 50 µM 0.488941149395664 0.297548245982949 no 988 0.312441680993559 1562 6615653
SGTC_2369 9071472 200 µM 0.488035143922634 0.297894873002085 no 989 0.312762474121117 1549 17296037
SGTC_1913 st060213 96.1 µM 0.485004938861002 0.299055529130637 no 990 0.313836421064334 1581 688959
SGTC_2518 prenyletin 46.28 µM 0.483978027291374 0.299449331234011 no 991 0.314200731567716 1474 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2348 9022543 33.42 µM 0.483970614666376 0.299452174696775 no 992 0.314203361953503 1536 3162678 YDL140C RPO21
SGTC_1315 1237-0019 3.69 µM 0.483964291427014 0.29945460028385 no 993 0.314205605775932 1568 825140
SGTC_1279 0874-0590 65.2 µM 0.483078759404831 0.299794377244581 no 994 0.314519907531171 1530 3523074
SGTC_1559 coumarin 343 70.1 µM 0.482411321168619 0.300050587347674 no 995 0.31475689017877 1564 108770 A hepatotoxic, DNA x-linker.
SGTC_858 0438-0351 2.77 µM 0.482058457853161 0.300186081314469 no 996 0.314882209743411 1482 2799119
SGTC_514 4466-0038 2.65 nM 0.481957888960732 0.300224703253882 no 997 0.314917930735023 1544 5722064
SGTC_24 0417-1663 219 µM 0.481103296626137 0.300552986934902 no 998 0.315221542604676 1498 4329390
SGTC_3178 9107506 49.47 µM 0.480070080930817 0.300950103417765 no 999 0.315588780884778 1530 8897194
SGTC_23 0213-0011 39.996 µM 0.479089165146581 0.301327337201198 no 1000 0.315937598689903 1581 627608
SGTC_645 0845-0943 5.41 µM 0.477576988404844 0.301909296339181 no 1001 0.316475656264136 1500 1885106
SGTC_889 0919-1524 82.7 µM 0.477457976870026 0.301955119193136 no 1002 0.31651801905542 1483 3905452
SGTC_52 0329-0193 875 nM 0.475823400453575 0.302584793852366 no 1003 0.317100098641937 1587 3739292
SGTC_2742 clothiapine 36.27 µM 0.475084330547401 0.302869692842472 no 1004 0.317363433322326 1578 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_988 1497-1057 103 µM 0.473838507017364 0.30335020843984 no 1005 0.317807536384655 1581 3533044
SGTC_426 0988-0037 14.6 µM 0.473254056767338 0.303575748930572 no 1006 0.318015967806904 1533 5383008
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.472850045960738 0.303731701244391 no 1007 0.318160083149107 1607 16725076
SGTC_2659 sanguinarine 24.21 µM 0.470303168674182 0.304715643922645 no 1008 0.319069216971376 1511 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1699 st031318 29.054 µM 0.469299023132162 0.305103967604552 no 1009 0.319427956705548 1580 5340658
SGTC_229 benomyl 22.8748 µM 0.469242461250886 0.305125847779513 no 1010 0.319448168963195 1502 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2570 licareol 100 µM 0.468750592952657 0.305316149530028 no 1011 0.319623959575128 1492 443158
SGTC_1030 k029-0042 36.7 µM 0.467248377653074 0.305897675897066 no 1012 0.320161092608499 1565 6080581
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.465873905912297 0.306430180208889 no 1013 0.320652880005635 1474 88881 An O-methylated flavonoid and antioxidant.
SGTC_268 camptothecin 39.6153 µM 0.465596424563018 0.306537732998613 no 1014 0.320752201356663 1543 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_991 3996-0057 64.7 µM 0.465131002845883 0.306718169580247 no 1015 0.320918822674519 1547 715343
SGTC_2806 7952793 58.44 µM 0.465028194165022 0.306758033185879 no 1016 0.320955633123464 1566 2972490
SGTC_368 fentichlor 4.58 µM 0.464324091222806 0.307031107358037 no 1017 0.321207783101651 1492 7329 A pesticide.
SGTC_704 1310-0270 142 µM 0.464304233054007 0.307038810559233 no 1018 0.321214895810019 1489 5718033
SGTC_2374 9071832 200 µM 0.463677422167876 0.307282001127684 no 1019 0.321439437768687 1504 17381698
SGTC_405 ebelactone b 50 µM 0.463564450461589 0.307325840995805 no 1020 0.321479914476 1513 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2248 tofa 1.1 µM 0.46353791746353 0.307336137806225 no 1021 0.321489421308825 1539 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_475 α-linolenic acid 10 µM 0.463471987946844 0.307361724103643 no 1022 0.321513044509025 1595 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2491 paeonol 100 µM 0.463407571220874 0.307386724214275 no 1023 0.321536126358495 1501 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1272 0839-0021 27 µM 0.463145591899751 0.307488407524506 no 1024 0.321630006083585 1535 5027250
SGTC_495 decylubiquinone 155 µM 0.462051313516873 0.307913295024847 no 1025 0.322022261491055 1479 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_3201 9113999 49.47 µM 0.461629218846381 0.308077255256468 no 1026 0.322173618731251 1612 16649224
SGTC_2166 5933061 31.504 µM 0.459047572672645 0.309080913562702 no 1027 0.32310000200812 1692 2877375
SGTC_1154 4088-0362 150 µM 0.457994840956408 0.30949059066704 no 1028 0.323478073867242 1502 6618304
SGTC_477 mead ethanolamide 10 µM 0.457705954761415 0.309603053968638 no 1029 0.323581854647494 1493 16061185
SGTC_466 geldanamycin 89.2 µM 0.457111722036783 0.309834444623509 no 1030 0.323795372632362 1550 5288382 HSP90 inhibitor.
SGTC_196 k015-0023 18.111 µM 0.457009674243837 0.309874189006046 no 1031 0.323832045988016 1537 5211998
SGTC_3033 9090887 49.47 µM 0.456256870312743 0.310167450928014 no 1032 0.324102637212577 1493 19325384
SGTC_2854 9024559 71.43 µM 0.455955034495941 0.310285067868205 no 1033 0.32421115654764 1499 3163529
SGTC_2117 5521686 200 µM 0.454782697611273 0.310742078607334 no 1034 0.324632789600343 1494 803312
SGTC_3193 9111931 49.47 µM 0.454596324513168 0.310814759150471 no 1035 0.324699839744404 1581 17087244
SGTC_1399 3562-5772 25 µM 0.454572799100235 0.310823933959561 no 1036 0.32470830372128 1507 23847490
SGTC_2644 guaiazulene 100 µM 0.453097204197523 0.311399644443706 no 1037 0.3252393742324 1600 3515 A coloring agent.
SGTC_2351 9026858 72.31 µM 0.452954380936954 0.311455392148313 no 1038 0.325290795569631 1469 1409300
SGTC_2525 harmine 47.85 µM 0.452256798556128 0.311727739148656 no 1039 0.325541997258096 1619 5280953 A monoamine oxidase inhibitor
SGTC_2935 9038016 29.96 µM 0.451597522340567 0.311985225510836 no 1040 0.325779477627136 1553 6463195
SGTC_2997 9067075 71.4286 µM 0.450954227292231 0.312236558873169 no 1041 0.326011269524863 1596 27209819
SGTC_413 propylparaben 100 µM 0.450843079574145 0.312279992797225 no 1042 0.326051325056358 1500 7175 A pharmaceutical preservative.
SGTC_1773 st048542 73.5835 µM 0.450824783294378 0.312287142804761 no 1043 0.32605791888131 1468 3237138
SGTC_914 3820-6779 408 µM 0.449957492970747 0.312626152453277 no 1044 0.326370545364625 1492 2893481
SGTC_393 acivicin 6.25 µM 0.446840891097693 0.313845688632243 no 1045 0.327494972272643 1549 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3340 9146634 11.102 µM 0.446149271243287 0.314116598243444 no 1046 0.327744711924686 1549 4907387
SGTC_2746 daunorubicin 9.88 µM 0.446137422018802 0.314121240494257 no 1047 0.327748991278179 1596 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1677 st019204 53.9 µM 0.445186755816893 0.314493785201617 no 1048 0.328092398538898 1501 3945625
SGTC_1686 st019653 115.5 µM 0.444898211845596 0.314606896496338 no 1049 0.328196657471939 1650 97252
SGTC_84 0443-0269 128.823 µM 0.443589681320819 0.315120068060455 no 1050 0.328669633694243 1527 6150058
SGTC_948 3448-0295 75.3 µM 0.44271304276779 0.315464062630833 no 1051 0.328986653624516 1549 678569
SGTC_74 000s-0487 160.283 µM 0.441973474012775 0.315754395206284 no 1052 0.329254200536316 1456 677548
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.44159135001664 0.315904450231625 no 1053 0.329392472260535 1594 7104
SGTC_441 propafenone 146 µM 0.438214463425397 0.317231825307115 no 1054 0.330615412458975 1539 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.435953610658507 0.318121830799088 no 1055 0.331435193612231 1657 5282309
SGTC_1904 st060225 78 µM 0.435496042607242 0.318302084744236 no 1056 0.331601205436614 1532 66595
SGTC_3328 9140624 29.0385 µM 0.435259398565449 0.318395324969244 no 1057 0.331687076049657 1683 4904392
SGTC_166 k072-0058 166.424 µM 0.434810190076873 0.318572349450791 no 1058 0.331850103883112 1606 5846229
SGTC_2380 9035439 200 µM 0.432454994734311 0.319501164060691 no 1059 0.332705377654001 1640 6462575
SGTC_1859 st055998 20 µM 0.432084062489848 0.319647551482829 no 1060 0.332840158811279 1724 676301
SGTC_92 0063-0024 660.874 µM 0.430115376446474 0.320424958120292 no 1061 0.333555857653744 1581 3594437
SGTC_1560 lithocholic acid 53.1 µM 0.430013155618686 0.320465345264003 no 1062 0.333593035731554 1625 9903 A bile acid which acts as a detergent.
SGTC_862 0452-0056 10.2 µM 0.429933223622788 0.320496927638121 no 1063 0.333622108420712 1561 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2094 5332512 191.667 µM 0.429718476243809 0.320581784102432 no 1064 0.333700220810975 1680 755774
SGTC_3185 9108267 49.47 µM 0.426842484667183 0.321719121642202 no 1065 0.334747029938831 1536 4910486
SGTC_1856 st057054 55.7 µM 0.426437603234373 0.321879370315439 no 1066 0.334894502902734 1696 1266018
SGTC_1207 2099-0101 141 µM 0.424357748570887 0.32270308106451 no 1067 0.335652464730153 1696 5837381
SGTC_42 0133-0086 60.653 µM 0.423060676385464 0.323217217866482 no 1068 0.336125496001629 1499 162923 Model of phenazepam hydroxylation.
SGTC_1654 st012436 41.8 µM 0.4212654300145 0.323929379528756 no 1069 0.33678063542967 1639 4323132
SGTC_3024 9090631 49.47 µM 0.419102598147078 0.324788216297524 no 1070 0.337570575984191 1687 25236383
SGTC_556 4058-0063 51.5 µM 0.418556904758866 0.325005052600229 no 1071 0.337769995262446 1622 6615692
SGTC_1346 1488-2224 62.4 µM 0.418535798769472 0.325013440451229 no 1072 0.337777709192561 1671 3722427
SGTC_1772 st048439 82.2 µM 0.41850398737736 0.32502608296465 no 1073 0.337789335919385 1587 2927068 YDL195W SEC31
SGTC_2743 auranofin 4.32 µM 0.416874704540101 0.325673863217625 no 1074 0.338385028303902 1634 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3117 9124945 49.47 µM 0.4164728897413 0.325833700257367 no 1075 0.338532000616239 1510 17592065
SGTC_2870 9038528 12.99 µM 0.412095121563731 0.327577192526115 no 1076 0.34013485211966 1582 6463316
SGTC_2560 caryophyllene 100 µM 0.411594532104746 0.327776798230008 no 1077 0.340318320015831 1603 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_332 4112-0506 40.9 µM 0.411038621297483 0.32799852051927 no 1078 0.34052210769343 1639 2790355
SGTC_3095 9117207 49.47 µM 0.410950206464308 0.328033789930596 no 1079 0.340554523397992 1732 17015229
SGTC_1955 wogonin 32.4 µM 0.410307593145156 0.328290179780492 no 1080 0.340790161362683 1707 5281703 A flavanone.
SGTC_2627 acetyl isogambogic acid 100 µM 0.410053057965274 0.32839175659669 no 1081 0.340883513295293 1536 6857789 A caspase activator and apoptosis inducer.
SGTC_275 trichlorophene 5.69 µM 0.408219241956219 0.329123948234354 no 1082 0.341556361316382 1645 62616
SGTC_1800 st050079 29.0735 µM 0.406277356964723 0.329900003982338 no 1083 0.342269410338264 1628 3645560
SGTC_2296 7971656 126.45 µM 0.405662251044136 0.330145978140204 no 1084 0.342495391173157 1586 666570
SGTC_1924 st058459 75.1 µM 0.405492632982702 0.330213819476699 no 1085 0.342557716267744 1613 688683
SGTC_1723 st034307 2.5525 µM 0.405087561037373 0.330375856773638 no 1086 0.34270657475785 1596 867466
SGTC_1463 k081-0032 34.1 µM 0.403341568604076 0.331074654195125 no 1087 0.343348482799405 1531 977755
SGTC_2260 7964312 200 µM 0.402693410627028 0.331334216041935 no 1088 0.343586891006908 1728 231951
SGTC_1343 1487-0095 224 µM 0.401143564644369 0.331955196969068 no 1089 0.344157214075048 1727 4560101 YGL055W OLE1
SGTC_3353 9151644 39.2805 µM 0.401013905925154 0.332007168633604 no 1090 0.344204942882811 1619 4909158
SGTC_107 0358-0022 2.6945 µM 0.399779757162731 0.332502019489897 no 1091 0.344659370822436 1705 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1646 st011709 75.6 µM 0.398086119544721 0.333181584745716 no 1092 0.345283352841957 1710 5757843
SGTC_2798 7813637 45.45 µM 0.397553661015219 0.333395344924972 no 1093 0.345479612023398 1683 956368
SGTC_14 0354-0009 295 µM 0.396431692274825 0.33384594627195 no 1094 0.345893295054422 1677 1713507
SGTC_2443 5493264 126.67 µM 0.396190803281893 0.333942722585535 no 1095 0.345982137664607 1736 5340055
SGTC_1084 voriconazole 435 nM 0.396186433018508 0.333944478425646 no 1096 0.345983749545953 1716 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_488 nitrendipine 139 µM 0.395941180403362 0.33404301935998 no 1097 0.34607421037753 1677 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2128 5255449 168.493 µM 0.395667603564915 0.334152954287294 no 1098 0.346175128894966 1588 736008
SGTC_2021 4019055 173 µM 0.395640321176929 0.334163918303356 no 1099 0.346185193570314 1646 44827708 YER133W GLC7
SGTC_3332 9141069 11.198 µM 0.39535395535274 0.334279009122888 no 1100 0.346290842601052 1582 17332883
SGTC_1392 3455-1037 33.9 µM 0.395005786955497 0.334418959469125 no 1101 0.346419308585921 1694 981132
SGTC_3021 9087658 49.47 µM 0.394104886726151 0.334781193603583 no 1102 0.346751801649865 1667 25237042
SGTC_2596 sinensetin 100 µM 0.393458486951557 0.335041192932453 no 1103 0.346990439612349 1608 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_570 0987-0065 62.6 µM 0.392405620545591 0.33546485328366 no 1104 0.347379266903131 1692 3104428
SGTC_828 2074-0507 139 µM 0.392150040853209 0.335567726964123 no 1105 0.347473677638125 1736 X828
SGTC_791 1348-1292 225 µM 0.392109084239227 0.335584213604828 no 1106 0.347488807826538 1736 5437054
SGTC_2809 7964133 12.99 µM 0.391947915756093 0.335649093302864 no 1107 0.347548349031329 1659 1253665
SGTC_2226 7298446 200 µM 0.391890496442076 0.335672209103726 no 1108 0.347569562618114 1718 3283010
SGTC_3263 9137018 49.47 µM 0.391255354749605 0.335927945176057 no 1109 0.347804247781654 1543 43844957
SGTC_356 1634-0012 32.5 µM 0.3904230489768 0.336263183218318 no 1110 0.348111873452728 1782 735457
SGTC_1695 st026914 34.495 µM 0.389132092267728 0.336783415348716 no 1111 0.348589217253711 1625 3289191
SGTC_619 1652-1634 108 µM 0.388881402409412 0.336884475072443 no 1112 0.348681940099487 1627 5400454
SGTC_2136 5328288 199.296 µM 0.38703942179935 0.337627387026061 no 1113 0.349363511759626 1619 262395
SGTC_1048 3161-0300 24.5 µM 0.38687694046588 0.337692949812179 no 1114 0.34942365663691 1596 2165101
SGTC_652 0437-0092 114 µM 0.386644951246998 0.337786568238043 no 1115 0.349509537442254 1603 3091274
SGTC_153 4077-0274 519.67 µM 0.386299442899777 0.337926015509285 no 1116 0.349637456523437 1773 3121976
SGTC_1878 temozolomide 1 mM 0.385946686453149 0.338068411066552 no 1117 0.349768076715877 1781 5394 DNA alkylating agent.
SGTC_3142 9086498 49.47 µM 0.385650246695464 0.338188091446028 no 1118 0.349877857472463 1752 25236367
SGTC_520 3584-0023 682 µM 0.384299998074606 0.338733428376887 no 1119 0.350378054711013 1618 1340790
SGTC_726 3448-4391 34.2 µM 0.381808448353137 0.339740600000299 no 1120 0.351301725898942 1759 1356692
SGTC_180 1486-1293 102.781 µM 0.380021133889664 0.340463801032279 no 1121 0.3519648636822 1829 4140536
SGTC_178 4092-0806 87.505 µM 0.378820169667397 0.340950077113232 no 1122 0.352410704256565 1629 2169044
SGTC_1740 st038286 13.222 µM 0.377580753789688 0.341452199649615 no 1123 0.352871032173568 1691 716786
SGTC_802 4112-3352 742 µM 0.377536194783439 0.341470257000868 no 1124 0.35288758572323 1751 704594
SGTC_1680 diphenhydramine 100 µM 0.377077847459599 0.341656021398603 no 1125 0.353057876667467 1647 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2861 9024595 19.48 µM 0.376993072889541 0.341690384038558 no 1126 0.353089376405011 1675 16482810
SGTC_1117 retinoic acid 1.10837 µM 0.376690140634121 0.34181318573072 no 1127 0.353201945348648 1781 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_563 tetrahydrosecaminediol 614 µM 0.376433747826692 0.341917134493619 no 1128 0.353297230376037 1772 334274 A psychoactive constituent of the cannabis plant.
SGTC_1641 st009299 47.1 µM 0.376401461113103 0.341930225273537 no 1129 0.353309229962189 1718 4046054
SGTC_2436 5633522 8.09 µM 0.376182137802084 0.342019155835325 no 1130 0.353390746886022 1793 5724242
SGTC_1143 3454-2408 5.08 µM 0.375737557641926 0.342199449758452 no 1131 0.353556006711079 1659 X1143
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.374126524812483 0.342853085115022 no 1132 0.354155092685274 1659 6708630 An antioxidant.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.374031426398585 0.342891683593711 no 1133 0.354190467715755 1649 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_767 0929-0023 86 µM 0.373325035018112 0.343178444546169 no 1134 0.354453272945372 1656 1204563
SGTC_3216 9129716 49.47 µM 0.373032989448113 0.343297027414101 no 1135 0.354561945581826 1589 8056934
SGTC_148 3253-0744 288.01 µM 0.372597412019303 0.343473918959879 no 1136 0.354724049637245 1622 6893655
SGTC_1567 st069303 68.4 µM 0.372244157368098 0.343617403736918 no 1137 0.354855535853958 1664 5581319
SGTC_992 3909-8734 162 µM 0.371841055751363 0.34378116285442 no 1138 0.355005596915961 1643 4288319
SGTC_3012 9080433 71.4286 µM 0.370483144735506 0.344333026680791 no 1139 0.355511266534533 1787 17688859
SGTC_697 0508-1955 564 µM 0.370334612785059 0.344393411166965 no 1140 0.355566593487593 1790 6243113
SGTC_1558 st069300 45.6 µM 0.369947944485618 0.3445506266966 no 1141 0.355710638580603 1772 24208000
SGTC_3180 9109287 49.47 µM 0.369674936502032 0.344661645235793 no 1142 0.355812354340134 1682 18891271
SGTC_2243 6634756 200 µM 0.369486803931424 0.344738157024689 no 1143 0.355882453676906 1766 885676
SGTC_2925 9010536 32.5 µM 0.369196835318367 0.344856097033977 no 1144 0.355990507283377 1750 2994177
SGTC_1341 1486-1360 280 µM 0.368458755895215 0.345156366821903 no 1145 0.356265596622387 1642 3976547
SGTC_1057 3448-5381 134 µM 0.368075128050558 0.345312475071287 no 1146 0.356408607989777 1764 5497911
SGTC_3071 9117417 49.47 µM 0.367384011849019 0.34559377481777 no 1147 0.356666297884929 1793 45595590 YGL055W OLE1
SGTC_2650 prasterone 100 µM 0.367343836596749 0.345610129668059 no 1148 0.35668127966096 1695 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_3086 9117350 49.47 µM 0.36695293436573 0.345769276189755 no 1149 0.356827062771505 1641 2679265
SGTC_1298 1079-1278 263 µM 0.366320335241259 0.346026881574197 no 1150 0.357063028639689 1686 2840950
SGTC_2830 7992007 71.43 µM 0.365014814191313 0.346558737708478 no 1151 0.357550173985413 1631 1952075
SGTC_625 k213-0058 121 µM 0.362084271789148 0.347753711927019 no 1152 0.358644528327288 1744 3655420
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.361905473970067 0.347826668640543 no 1153 0.358711334600519 1754 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3319 9138450 16.7555 µM 0.361312146126286 0.348068810665627 no 1154 0.358933057431073 1672 2029690
SGTC_601 0986-0029 62.9 µM 0.360819019420071 0.348270106926769 no 1155 0.359117371911609 1687 24747981
SGTC_361 000s-0510 1.45 µM 0.360756028449322 0.348295823169058 no 1156 0.35914091821978 1681 660
SGTC_1124 fisetin 1.16336 µM 0.359539895905191 0.348792449316177 no 1157 0.359595618825303 1657 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1499 4480-0877 67.3 µM 0.359277767891774 0.348899527243678 no 1158 0.359693652113389 1706 2861909
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.35849405988856 0.349219739628133 no 1159 0.359986806210948 1668 688667
SGTC_390 dec-rvkr-cmk 16.7 µM 0.357125198999673 0.349779294924178 no 1160 0.360499040306412 1729 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3254 9136651 49.47 µM 0.35633643857215 0.350101868332377 no 1161 0.360794311914968 1671 16454030
SGTC_1245 0418-0076 17.2 µM 0.355220726353878 0.35055833746047 no 1162 0.361212119273852 1715 6790114
SGTC_2445 5742597 35.57 µM 0.355159571638463 0.350583363814276 no 1163 0.361235025034076 1641 1774255
SGTC_2847 9005661 71.43 µM 0.355109764871198 0.350603746724649 no 1164 0.361253680739386 1703 2991449
SGTC_587 k089-0003 57 µM 0.354680997581798 0.350779233138161 no 1165 0.361414294168609 1775 9659696
SGTC_3247 9135149 49.47 µM 0.354377994395035 0.350903265865805 no 1166 0.361527811917719 1695 8934436 YOR116C RPO31
SGTC_1122 capsaicin 818.572 nM 0.354129561921413 0.351004972220418 no 1167 0.361620894275383 1761 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2722 naftopidil 47.16 µM 0.353401278677681 0.35130318730319 no 1168 0.361893813672996 1752 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2292 7671323 168.05 µM 0.351519079538835 0.352074327920037 no 1169 0.362599480617008 1678 937504
SGTC_2130 NSC 7 2.4545 µM 0.34925338009743 0.353003396608589 no 1170 0.363449547318321 1809 21448
SGTC_2281 7943571 200 µM 0.347967966480532 0.353530881356297 no 1171 0.363932120476253 1877 1244024
SGTC_2043 5101342 149 µM 0.346809749744572 0.354006410414367 no 1172 0.364367125992893 1722 678451
SGTC_286 k060-0067 22.9 µM 0.34639988491086 0.35417474323312 no 1173 0.364521105795576 1701 5985051
SGTC_699 0375-0592 111 µM 0.346358759863691 0.354191634997368 no 1174 0.364536557039382 1816 762578
SGTC_496 calpeptin 138 µM 0.345693387099216 0.354464971066277 no 1175 0.364786577275856 1665 73364 A calpain inhibitor.
SGTC_1875 nocodazole 6 µM 0.345482348075366 0.354551681861733 no 1176 0.364865889244155 1824 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2619 obliquin 87.91 µM 0.345281647494424 0.354634151836264 no 1177 0.364941321218911 1778 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2002 4023503 131 µM 0.343496081812276 0.355368159097912 no 1178 0.365612643994149 1894 4736863 YCR052W RSC6
SGTC_431 k089-0097 107 µM 0.343295370600442 0.355450700730178 no 1179 0.365688131584069 1706 5499420
SGTC_3151 9099821 49.47 µM 0.343116887058458 0.355524107023586 no 1180 0.365755263705372 1668 17174189
SGTC_3013 9080133 71.4286 µM 0.342489653640279 0.355782116610417 no 1181 0.365991214470377 1769 17050193
SGTC_1555 citronellol 128 µM 0.341682464753004 0.356114247277172 no 1182 0.366294934921242 1840 8842 A terpine precursor.
SGTC_1440 4100-1550 40 µM 0.33860769979305 0.357380406451475 no 1183 0.367452640668392 1732 742806
SGTC_2987 9018338 71.43 µM 0.338262387712417 0.357522701126464 no 1184 0.367582732540928 1717 5055682
SGTC_2342 7990637 118.86 µM 0.338246713736592 0.357529160459224 no 1185 0.367588637869803 1743 2033102 YER133W GLC7
SGTC_2914 7968218 45.32 µM 0.338124888992633 0.357579366506116 no 1186 0.367634537641133 1816 2977111
SGTC_1607 st000305 50.6 µM 0.337763655553229 0.357728251430397 no 1187 0.367770650269436 1787 5457690
SGTC_1263 0774-1208 64.8 µM 0.337398809165401 0.35787864743258 no 1188 0.367908141113655 1865 906585
SGTC_3272 9137413 49.47 µM 0.337236868686655 0.357945409174895 no 1189 0.367969173134368 1622 17614870
SGTC_1712 st032288 53.4 µM 0.336596473343265 0.358209461740937 no 1190 0.368210557547931 1717 2883011
SGTC_3262 9137218 49.47 µM 0.335949839766488 0.358476155328432 no 1191 0.368454346140439 1723 17650664
SGTC_3187 9109394 49.47 µM 0.335481685543669 0.358669281079907 no 1192 0.368630878941289 1671 17098090
SGTC_2515 chrysin 20.77 µM 0.334137516175083 0.359223986503147 no 1193 0.369137895770613 1806 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_908 3448-7491 47.7 µM 0.334064361658046 0.359254184090045 no 1194 0.369165495987304 1671 1203031
SGTC_2034 5197015 53.07 µM 0.333989716442887 0.359284997931245 no 1195 0.36919365931964 1835 780676
SGTC_189 3970-0742 2.116 µM 0.333279400198839 0.359578265065443 no 1196 0.369461693825084 1844 2891807
SGTC_2791 5663188 71.43 µM 0.333265857519112 0.35958385721412 no 1197 0.369466804708679 1821 54690634
SGTC_2197 6588183 93.1375 µM 0.333199586558432 0.359611222768363 no 1198 0.369491815096353 1752 884136
SGTC_336 4111-0029 111 µM 0.332718657027968 0.359809836638762 no 1199 0.369673332461142 1690 3131175
SGTC_2784 7567673 72.73 µM 0.332264155442735 0.359997571119747 no 1200 0.369844901817139 1689 3471247
SGTC_3107 9121808 49.47 µM 0.331351602842744 0.360374608140053 no 1201 0.370189458608771 1839 662681
SGTC_315 k915-0449 187 µM 0.328964219856608 0.361361638692522 no 1202 0.371091366313668 1786 20970215 YNL149C PGA2
SGTC_918 glabranin 770.725 nM 0.327712592889533 0.361879476025354 no 1203 0.371564490503423 1771 124049 Also referred to as licorice root.
SGTC_3238 9133470 49.47 µM 0.327664200918035 0.361899502387428 no 1204 0.371582786925866 1834 3534688
SGTC_2708 st078559 56 µM 0.32718994572885 0.362095786480344 no 1205 0.371762112457184 1741 17250902
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.327141107488287 0.362116001645755 no 1206 0.371780580770132 1848 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2492 derrusnin 100 µM 0.326747509526055 0.362278934079535 no 1207 0.37192943167381 1711 1715307 Part of coumarin class of compounds.
SGTC_1293 1000-1278 195 µM 0.32663093947984 0.362327193798402 no 1208 0.371973519817201 1795 678847
SGTC_631 k072-0230 41.5 µM 0.325799623961012 0.36267141982617 no 1209 0.372287981629287 1784 5773147
SGTC_186 3455-3465 67.277 µM 0.325328446457345 0.362866571429399 no 1210 0.372466251829236 1737 755278
SGTC_574 1315-0397 40 µM 0.324821669178778 0.363076507453152 no 1211 0.372658021721392 1743 6794277
SGTC_810 3825-7150 143 µM 0.324286347284532 0.363298312973137 no 1212 0.372860627485367 1916 22330411 YGL099W LSG1
SGTC_1787 fluconazole 80 µM 0.322564112900919 0.364012215036454 no 1213 0.373512687890408 1740 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2362 9071156 126 µM 0.322137498098436 0.36418912883757 no 1214 0.373674265881533 1805 653133
SGTC_2591 skatole 100 µM 0.321450910322288 0.36447391214534 no 1215 0.373934353812968 1735 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3287 9117173 37.0625 µM 0.320432702459122 0.364896382759938 no 1216 0.374320169195152 1787 2789709
SGTC_892 0929-0076 29 µM 0.320312163669348 0.364946407090054 no 1217 0.374365851628177 1731 5751038
SGTC_3342 9147791 14.508 µM 0.320152714502051 0.365012582994894 no 1218 0.374426283233161 1754 1838168
SGTC_2555 cholic acid 100 µM 0.320130029257286 0.365021998338517 no 1219 0.37443488124436 1786 6708657 Influences liver metabolism.
SGTC_2871 9038510 12.99 µM 0.319463767536687 0.365298561626902 no 1220 0.374687431178794 1902 4945164
SGTC_2814 7977482 42.97 µM 0.317881883062183 0.365955477662632 no 1221 0.375287267793327 1855 6456762
SGTC_46 0329-0187a 2.197 µM 0.317510092870809 0.366109929723666 no 1222 0.375428291186369 1801 46494817
SGTC_2006 4011487 200 µM 0.317304951612308 0.366195160439693 no 1223 0.375506110255474 1849 45595294
SGTC_860 0443-0016 25.1 µM 0.316371656415131 0.366583002960053 no 1224 0.37586021392612 1771 5337942
SGTC_376 3970-0862 59.1 µM 0.315928339027029 0.366767276822844 no 1225 0.376028450642564 1862 3135186
SGTC_1656 st012921 11 µM 0.315098640109963 0.367112240496416 no 1226 0.376343380501623 1838 6732821
SGTC_306 1672-3436 11.6 µM 0.314901675728449 0.367194148090306 no 1227 0.376418154620702 1801 6797378
SGTC_211 3455-0679 143.504 µM 0.313165287873674 0.367916485718896 no 1228 0.377077544596572 1764 748649
SGTC_1125 tnp00248 1.32998 µM 0.312829845536619 0.368056083726433 no 1229 0.37720496957592 1939 24207736
SGTC_1064 honokiol 6.76 µM 0.312625398570834 0.368141175121776 no 1230 0.377282639708412 1765 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_237 nikkomycin 200 µM 0.312460514568698 0.368209805014615 no 1231 0.377345283346245 1858 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_790 1575-0012 79.1 µM 0.311936852892427 0.36842779730821 no 1232 0.377544257168028 1885 378741 YLR208W SEC13
SGTC_793 0488-0545 106 µM 0.310368579409423 0.369080898540513 no 1233 0.378140342581945 1721 292548
SGTC_929 2805-0021 398 µM 0.310151869894209 0.369171176131591 no 1234 0.378222734601216 1772 3098024
SGTC_165 k038-0023 64.381 µM 0.309452162456509 0.369462711892272 no 1235 0.378488798128668 1722 46368543
SGTC_97 0535-0701 19.132 µM 0.309348264947586 0.369506007589291 no 1236 0.378528310038547 1690 2832013 YGL099W LSG1
SGTC_1044 1222-0021 1.78 µM 0.308166691243818 0.369998503904344 no 1237 0.378977748212421 1818 4306703
SGTC_2220 6782180 200 µM 0.30676606702505 0.370582579708195 no 1238 0.37951071914779 1870 833803
SGTC_2781 5567276 71.43 µM 0.306463956796409 0.370708602189987 no 1239 0.379625709361534 1822 2853274
SGTC_2372 9071633 200 µM 0.305740712004544 0.371010353386617 no 1240 0.379901036468396 1878 21321366
SGTC_3066 9117245 49.47 µM 0.305381778235515 0.371160136706572 no 1241 0.380037699122277 1858 17176980
SGTC_2526 patulin 37.61 µM 0.305215402034914 0.371229572236699 no 1242 0.38010105130392 1800 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1679 SEC14.276 6.7 µM 0.304922291503059 0.37135190933456 no 1243 0.380212668792192 1925 1005053 YMR079W SEC14
SGTC_825 1988-2224 89.6 µM 0.304003930649323 0.371735294587693 no 1244 0.380562448287365 1773 1180859
SGTC_326 k292-0812 17.5 µM 0.302792053208072 0.372241407995133 no 1245 0.381024169965337 1883 3579357
SGTC_2603 homopterocarpin 100 µM 0.302691242095541 0.372283519450991 no 1246 0.381062586340557 1759 101795 A weak amylase inhibitor.
SGTC_1093 fluphenazine 7.97 µM 0.301842583163976 0.37263808713122 no 1247 0.381386033633226 1801 6602611 An atypical antipsychotic.
SGTC_69 0096-0274 206.684 µM 0.301037691106846 0.372974468870049 no 1248 0.381692876733224 1852 6741392
SGTC_853 0419-0306 21 µM 0.300487360993359 0.373204519460969 no 1249 0.381902717861272 1738 762713
SGTC_842 0271-0008 11.1 µM 0.299648197607363 0.373555395978475 no 1250 0.382222758034895 1848 1221709
SGTC_79 0052-0007 94.094 µM 0.297849554849889 0.374307809190079 no 1251 0.382908995367882 1889 2801472
SGTC_2882 9058044 58.44 µM 0.294904110994682 0.375540988717417 no 1252 0.384033565709454 1688 18076804
SGTC_2759 disulfiram 3.38 µM 0.294870131342609 0.375555222549581 no 1253 0.384046544858324 1748 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2063 5246145 200 µM 0.294058098391717 0.375895427671127 no 1254 0.384356754335929 1845 711240
SGTC_515 4092-1064 102 µM 0.293707435931663 0.376042369245356 no 1255 0.384490735876055 1935 717353
SGTC_138 0850-0259 40.9225 µM 0.291930713178575 0.37678716286399 no 1256 0.385169800051451 1824 6813004
SGTC_201 4262-0159 12.803 µM 0.291919246152596 0.376791971279061 no 1257 0.385174183899903 1920 1341029
SGTC_1781 st038725 66.3 µM 0.288836279784466 0.378085428392609 no 1258 0.386353333760353 1754 4270275 YIL048W NEO1
SGTC_839 0122-0028 230 µM 0.288063860633793 0.378409711321074 no 1259 0.386648927812172 1822 759448
SGTC_3206 9114350 49.47 µM 0.28778022502083 0.378528810911113 no 1260 0.386757487731644 1838 17087243
SGTC_824 1304-0008 100 µM 0.286895656396967 0.378900318445101 no 1261 0.38709610822319 1804 768245
SGTC_1975 st070967 30.8 µM 0.286427998334384 0.379096774107248 no 1262 0.387275166505109 1929 261391
SGTC_1170 0310-0127 64.8 µM 0.28453092239167 0.379894025158094 no 1263 0.388001770102024 1839 774975
SGTC_1390 3413-2614 145 µM 0.284284551470323 0.379997600714807 no 1264 0.388096162052085 1791 3421432
SGTC_702 1488-0190 94 µM 0.284250138361017 0.38001206884187 no 1265 0.388109347253309 1937 949357
SGTC_105 0111-0055 734.78 µM 0.283683120464421 0.380250481432336 no 1266 0.388326615727713 1823 5179370
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.282454857156707 0.380767082153745 no 1267 0.388797378306748 1839 6708739 YPR165W RHO1
SGTC_2693 st077581 40.7 µM 0.281248058664344 0.38127486201667 no 1268 0.389260073055529 1888 25238761
SGTC_610 4215-0184 155 µM 0.278815221621777 0.382299138059708 no 1269 0.39019331617241 1830 5605015
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.277874349952477 0.382695486404361 no 1270 0.390554407270662 1913 23847180
SGTC_3118 9124250 49.47 µM 0.277049024954797 0.383043261152339 no 1271 0.390871231200103 1801 1504786
SGTC_1854 st056233 32.9 µM 0.275542473912387 0.383678333339784 no 1272 0.391449749366262 1961 5393174
SGTC_113 0099-0221 2.5 µM 0.274999630499736 0.383907240487431 no 1273 0.391658261093043 1919 89219
SGTC_1614 st002383 48.6 µM 0.272859435810778 0.384810115474745 no 1274 0.392480634596583 1854 1947235
SGTC_272 doxorubicin 8.13 µM 0.272569228377756 0.38493259230187 no 1275 0.3925921843671 1861 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1225 1216-0074 20.6 µM 0.271329421094747 0.385455959832627 no 1276 0.393068840063352 1799 4241466
SGTC_1452 4194-0072 190 µM 0.270961369891538 0.385611367775265 no 1277 0.393210371748661 1962 1343545
SGTC_868 0527-0199 213 µM 0.269986170776179 0.386023229892721 no 1278 0.39358544639793 1833 2849450
SGTC_2532 xanthone 78.9 µM 0.267738964376585 0.386972795529957 no 1279 0.394450127572836 1896 7020 An insecticide.
SGTC_2075 5212009 200 µM 0.266401582232838 0.387538233132185 no 1280 0.394964973399533 1923 780898
SGTC_2257 7960413 200 µM 0.266042977621401 0.387689889753037 no 1281 0.395103054988009 1885 2974689 YIL048W NEO1
SGTC_3026 9090633 49.47 µM 0.265441251763786 0.387944402689957 no 1282 0.395334780601807 1804 25236842
SGTC_2327 6189656 200 µM 0.263057714037701 0.388953043476688 no 1283 0.396253047837373 1928 5349088
SGTC_1804 st050076 49.1 µM 0.262051989422291 0.389378860661421 no 1284 0.39664068023957 1889 3895976
SGTC_1297 1068-0111 14.1 µM 0.261899699669288 0.389443350735657 no 1285 0.396699385584065 1779 767057
SGTC_848 0368-0089 85.6 µM 0.261898710705096 0.389443769541838 no 1286 0.396699766822119 1943 762535
SGTC_649 1123-0311 367 µM 0.26185988538415 0.38946021137549 no 1287 0.396714733761373 1939 693629 YIL048W NEO1
SGTC_3047 9092122 49.47 µM 0.260869509101265 0.389879684960303 no 1288 0.397096569545186 1803 17173831
SGTC_3160 9100216 49.47 µM 0.260276164033306 0.390131057574537 no 1289 0.397325378748604 1961 17191039
SGTC_1474 0330-0125 5.35 µM 0.258487918660373 0.390888931201265 no 1290 0.398015185853463 1859 X1474
SGTC_208 k072-0098 12.366 µM 0.256964328706848 0.391534968842092 no 1291 0.398603155097082 1895 5948901
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.255451052873279 0.3921769293264 no 1292 0.39918737192432 1918 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1527 coumarin 137 µM 0.255383170945175 0.392205733028539 no 1293 0.399213583794295 1918 323 A hepatotoxic, DNA x-linker.
SGTC_2776 terbinafine 19.92 µM 0.255358859019008 0.392216049223895 no 1294 0.399222971691308 1909 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_140 0062-0056 502.533 µM 0.253729439068977 0.392907627678664 no 1295 0.399852294524293 1814 3758964
SGTC_1066 ketoconazole 628 nM 0.253217143102096 0.393125132614988 no 1296 0.400050209915109 1920 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1410 3909-8106 77.9 µM 0.253041757002237 0.393199603769347 no 1297 0.400117972760044 1949 1039210
SGTC_351 caspofungin 25 nM 0.252931267959168 0.393246520820059 no 1298 0.400160663273867 1890 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1378 2093-0007 380 nM 0.252254602396616 0.393533887658486 no 1299 0.400422137836816 1834 3618014
SGTC_3281 9140613 49.47 µM 0.251328288319478 0.393927369435906 no 1300 0.400780152992796 1766 16013766
SGTC_1888 azatryptophan 97.5 µM 0.250916464527541 0.394102339677651 no 1301 0.400939347346261 1853 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2993 9054257 71.4286 µM 0.250682503450337 0.394201751486836 no 1302 0.401029794526709 1846 6470217 YGL055W OLE1
SGTC_3289 9119912 71.43 µM 0.248949806749542 0.394938201397278 no 1303 0.401699803800833 1876 17014829
SGTC_1040 k898-0338 155 µM 0.247692149536042 0.39547298013704 no 1304 0.402186303199555 2039 20969351
SGTC_302 1094-0063 18.9 µM 0.246813902729205 0.395846543479457 no 1305 0.402526125237398 1857 5440289
SGTC_1423 4048-0112 5.59 µM 0.246584324013706 0.395944210853601 no 1306 0.402614968808576 1961 X1423
SGTC_3219 9131112 49.47 µM 0.246581049184435 0.3959456040787 no 1307 0.402616236155517 1948 17612988 YMR079W SEC14
SGTC_205 1486-1330 71.903 µM 0.246433862492655 0.396008223736091 no 1308 0.40267319792296 1881 4118834
SGTC_40 0327-0103 19.753 µM 0.246066392153294 0.396164573404039 no 1309 0.402815419252812 1807 409036
SGTC_3327 9140648 26.9345 µM 0.245973289837956 0.396204188821831 no 1310 0.402851454503268 1968 8029710
SGTC_1416 3966-0321 25.3 µM 0.24595248018807 0.396213043559951 no 1311 0.402859508990952 1889 582530 YLR208W SEC13
SGTC_1837 st055472 66.5 µM 0.245527157039386 0.396394035028055 no 1312 0.403024141646237 1907 676091
SGTC_2533 agelasine 13.65 µM 0.243904628514197 0.397084688494336 no 1313 0.403652342193973 2031 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3274 9138298 49.47 µM 0.243707612934836 0.397168573139871 no 1314 0.403728638426631 1984 17015756
SGTC_2322 7413319 38.22 µM 0.241568275849198 0.398079758557479 no 1315 0.40455735316138 1875 1840400
SGTC_1860 st056228 74.6 µM 0.238071372760625 0.399570353241596 no 1316 0.405912868841255 1853 688679
SGTC_1160 4092-0570 10.5 µM 0.236466528632635 0.400254928080793 no 1317 0.406535338572326 1815 4994975
SGTC_1239 0337-0584 35.4 µM 0.236435067931625 0.400268351273745 no 1318 0.406547543577853 2013 914301 YML130C ERO1
SGTC_2873 9040596 71.43 µM 0.23582370050443 0.40052922397982 no 1319 0.406784738211072 1832 6463863
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.234916951504396 0.400916218764833 no 1320 0.407136596151079 1857 229346 A bile salt which induces apoptosis.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.234524943238501 0.401083555566836 no 1321 0.407288735584457 1925 91467 include heat shock
SGTC_2467 5474540 200 µM 0.234032526627224 0.401293779451706 no 1322 0.407479863577354 1880 5413519
SGTC_1269 0831-0796 3.05 µM 0.233041037584591 0.401717155383947 no 1323 0.407864769755078 1975 927758
SGTC_898 1000-0849 28.3 µM 0.232883664018029 0.401784366124648 no 1324 0.407925871970305 2020 6751807
SGTC_2046 4110841 106 µM 0.232273600980328 0.402044937884153 no 1325 0.408162757572703 2024 44119630 YMR134W ERG29
SGTC_674 0498-0004 451 µM 0.230689896552167 0.40272157693133 no 1326 0.408777861612847 1846 4231473
SGTC_3102 9121669 49.47 µM 0.230598144538954 0.402760787008128 no 1327 0.408813504605336 1900 41905072
SGTC_1492 4158-0558 28.5 µM 0.230528727853289 0.402790452768167 no 1328 0.408840471472857 1988 3967268
SGTC_1305 1181-0477 144 µM 0.229810498809511 0.403097426353601 no 1329 0.409119513091551 2013 6252086
SGTC_1340 1486-1359 257 µM 0.226912830427323 0.404336504634054 no 1330 0.41024576251466 1917 4309068
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.226731261517256 0.404414177807434 no 1331 0.4103163584519 2036 1273210
SGTC_1252 0493-0875 34.8 µM 0.22548504514738 0.404947396918814 no 1332 0.410800979040261 1872 3960963
SGTC_831 k061-1017 217 µM 0.224881953046438 0.405205505632212 no 1333 0.41103555455751 1994 1240153
SGTC_2704 st078022 71.1 µM 0.224533014606636 0.405354861614423 no 1334 0.411171290344267 2018 54697681
SGTC_1114 scopoletin 1.73284 µM 0.223328900225403 0.405870363933118 no 1335 0.411639768041045 2021 5280460 A coumarin with genotoxic properties.
SGTC_2531 methyl deoxycholate 70.07 µM 0.223319855289184 0.40587423684661 no 1336 0.411643287578743 1874 16667744 Haematoxylin.
SGTC_612 0302-0167 22.4 µM 0.221355963900916 0.40671536483609 no 1337 0.412407638822849 1988 235821
SGTC_2266 7929956 200 µM 0.221276780203181 0.406749287999383 no 1338 0.412438464297255 1893 2967153
SGTC_1373 2887-0003 58.5 µM 0.22057516888506 0.407049896511604 no 1339 0.412711618608178 1887 776948
SGTC_3214 9129694 49.47 µM 0.21907390765469 0.407693302355041 no 1340 0.413296237879823 2019 17158655
SGTC_1275 0867-0008 21.1 µM 0.218740963647803 0.407836028259144 no 1341 0.41342591861649 1926 3422836
SGTC_53 0973-0023 39.979 µM 0.218675080525472 0.407864272380918 no 1342 0.413451581023674 2078 674768
SGTC_2802 7925815 54.55 µM 0.216764267925248 0.408683646292412 no 1343 0.414196029965519 1886 1262923
SGTC_1226 3909-7979 35.4 µM 0.215357130595185 0.4092872951497 no 1344 0.414744445312601 2010 6615510
SGTC_3015 9080845 49.47 µM 0.215180915345608 0.40936290504535 no 1345 0.414813134881087 2024 5296973
SGTC_26 0302-0163 425.158 µM 0.214780510165595 0.409534722195583 no 1346 0.414969224463934 1938 3100915
SGTC_285 1486-1325 46 µM 0.214232600432191 0.409769862912739 no 1347 0.415182837359346 2014 22310230
SGTC_381 3461-2219 42.7 µM 0.212895276756991 0.410343924317508 no 1348 0.415704323269521 2024 2883159
SGTC_551 k048-0028 34.9 µM 0.212614584127873 0.410464439262488 no 1349 0.415813797519057 1999 6836383
SGTC_2015 5119600 184 µM 0.212032805177635 0.410714252062744 no 1350 0.416040720652892 2012 2828786
SGTC_2611 pyromycin 23.93 µM 0.211534798817973 0.410928122135156 no 1351 0.416234990491808 1871 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_730 1436-0052 41.2 µM 0.211138582404303 0.411098297180068 no 1352 0.416389567193356 1987 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1807 st050092 58.9 µM 0.211040398898796 0.411140469607237 no 1353 0.416427873720867 1936 5008496
SGTC_1987 st072290 61.9 µM 0.210027152077465 0.411575745966816 no 1354 0.416823240670078 1933 54697379
SGTC_455 paf C-16 10 µM 0.209755372407638 0.411692517166258 no 1355 0.416929302899673 1931 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2595 hexamethylquercetagetin 100 µM 0.209103018914482 0.411972835298711 no 1356 0.417183909023423 1937 386331
SGTC_1232 0279-0259 161 µM 0.207866500477402 0.412504293919159 no 1357 0.417666603285712 1871 1560000
SGTC_1575 cyproterone acetate 48 µM 0.206287259854988 0.413183288580428 no 1358 0.4182832648418 1886 9880 An androgen receptor antagonist and liver toxin.
SGTC_1984 st072354 53.1 µM 0.20627207859064 0.41318981703031 no 1359 0.418289193796206 1958 5762938
SGTC_2036 5160441 105 µM 0.206029314812929 0.413294216809441 no 1360 0.418384006297611 1969 134534 YIL048W NEO1
SGTC_519 k048-0011 62.8 µM 0.205914037172065 0.413343793734228 no 1361 0.418429030167346 1942 6836379
SGTC_1367 1812-0510 76.9 µM 0.205254979984559 0.413627257935301 no 1362 0.418686457960112 1990 1142582 YDR527W RBA50
SGTC_2885 9057732 51.95 µM 0.204368234385943 0.41400872321148 no 1363 0.419032875797275 1941 6471414
SGTC_2414 st077232 92.9 µM 0.20140755670655 0.415282950234624 no 1364 0.420189953442885 1806 729801
SGTC_2177 5811945 192 µM 0.201210968312186 0.415367590360751 no 1365 0.420266807705098 2024 5343475
SGTC_3226 9131256 49.47 µM 0.201044200553689 0.415439394444005 no 1366 0.420332006272083 1989 17178073
SGTC_1862 st057513 3.81 µM 0.19932471543478 0.416179905946839 no 1367 0.42100437346912 1946 5393163
SGTC_3300 9124615 50.48 µM 0.198168948923423 0.416677814474644 no 1368 0.421456440429242 2024 24824903
SGTC_1335 1486-0900 202 µM 0.198056123990762 0.416726427052745 no 1369 0.4215005763741 2019 X1335
SGTC_1495 4469-0029 237 µM 0.198032405792146 0.416736646611801 no 1370 0.421509854813169 1929 793680
SGTC_3009 9080819 71.4286 µM 0.197676535665216 0.416889988608488 no 1371 0.42164907463253 1922 17027216
SGTC_308 4092-1169 104 µM 0.196701910008071 0.417310012791506 no 1372 0.4220304076633 1984 2268590 YDL196W YDL196W
SGTC_223 busulfan 5 mM 0.195845177943975 0.417679307574046 no 1373 0.422365673919603 2031 2478 A DNA alkylator.
SGTC_1637 st007924 17.4 µM 0.195632212683854 0.417771117636222 no 1374 0.422449022677009 1955 683336
SGTC_482 fipronil 114 µM 0.195213437587428 0.417951666100136 no 1375 0.422612929880054 2069 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_15 0266-0086 27.098 µM 0.19431603007252 0.418338627785484 no 1376 0.42296421733608 2083 1712902 YIL048W NEO1
SGTC_2828 7998861 71.43 µM 0.193729875228237 0.418591420172943 no 1377 0.423193698968668 2084 2988188
SGTC_1674 st016616 23.6 µM 0.193582789121827 0.418654859627637 no 1378 0.423251287777149 1864 625830
SGTC_48 0382-0018 55 µM 0.191823911043971 0.419413641757746 no 1379 0.423940070232264 2085 762596
SGTC_1997 st073024 93.8 µM 0.191510504295741 0.419548877355175 no 1380 0.42406282580511 2086 686268
SGTC_103 0844-0104 51.839 µM 0.191172752799587 0.419694628395113 no 1381 0.424195125009763 2046 5375804
SGTC_1197 1601-0112 267 µM 0.191071755329595 0.419738214313929 no 1382 0.424234687959806 1912 7350313
SGTC_2651 TUB2.036 5 µM 0.190970431445951 0.419781942087431 no 1383 0.424274379540508 2072 15992207 YFL037W TUB2
SGTC_2071 5230951 39.92 µM 0.190757333736595 0.419873910688014 no 1384 0.42435785876096 2061 1799272
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.190595774459931 0.419943639274905 no 1385 0.424421150499327 1921 688664
SGTC_3041 9091929 49.47 µM 0.188525489017462 0.420837391089043 no 1386 0.42523236819739 2026 25236887
SGTC_1983 st071813 46.9 µM 0.18846840219538 0.420862041538304 no 1387 0.425254741518358 1960 11838595
SGTC_3246 9135460 32.98 µM 0.18790573210988 0.421105022610471 no 1388 0.425475274603702 2030 41446951
SGTC_693 4161-2696 114 µM 0.187109967937995 0.421448713334015 no 1389 0.42578720644916 2055 805759
SGTC_2283 7944793 200 µM 0.185741253787577 0.422040001153735 no 1390 0.426323837680732 1928 2970533
SGTC_2751 anetholtrithion 17.25 µM 0.185337868122926 0.422214298330669 no 1391 0.426482019018844 2054 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1033 k072-0102 21.3 µM 0.18345263404427 0.423029082455523 no 1392 0.427221440273025 2092 5965931
SGTC_1738 st035555 74 µM 0.183407653791789 0.423048526621989 no 1393 0.427239085436426 1993 5331140
SGTC_87 0100-0052 35.5 µM 0.182662801330613 0.423370540366353 no 1394 0.427531302430673 1998 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1524 corynanthine 62.1 µM 0.180157837841129 0.424453857609595 no 1395 0.428514328657592 1998 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2685 mycophenolic acid 18.85 µM 0.179930695643742 0.424552117759604 no 1396 0.42860348841051 2049 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2664 lyso-paf C-16 73.48 µM 0.179425941475612 0.424770487714548 no 1397 0.428801631773146 2046 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2740 felodipine 17.08 µM 0.177600108949376 0.425560583323902 no 1398 0.429518519487114 2109 3333 L-type calcium channel blocker
SGTC_1228 0124-0032 52.5 µM 0.177306483284769 0.425687672447687 no 1399 0.429633829277229 2065 X1228
SGTC_1307 1187-1599 12.2 µM 0.176382198655353 0.426087778158369 no 1400 0.429996844415473 1968 1538471
SGTC_3320 9137005 35.139 µM 0.175690882629761 0.426387085838532 no 1401 0.430268399247938 1946 4908713
SGTC_2738 aclarubicin 5.55 µM 0.17454409058847 0.426883686876312 no 1402 0.430718941625596 2063 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1643 st009866 20.2 µM 0.173747911606453 0.42722852842453 no 1403 0.43103179106129 2088 3156273 YOR207C RET1
SGTC_942 3253-1115 227 µM 0.17275921742047 0.427656829663104 no 1404 0.431420347369546 2084 46497897
SGTC_2194 5927483 104.545 µM 0.171145303812267 0.428356158244295 no 1405 0.4320547570265 2079 760979
SGTC_57 miconazole 162.5 nM 0.170338000622307 0.4287060572077 no 1406 0.432372163874233 2018 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3234 9132280 49.47 µM 0.169576915115599 0.429035975967142 no 1407 0.432671439324345 2007 17612295
SGTC_2076 5212012 200 µM 0.168423837340423 0.429535911689328 no 1408 0.433124928237519 2085 604802
SGTC_1137 ixabepilone 100 µM 0.167890017990513 0.429767396120551 no 1409 0.433334901576363 1958 154225 A novel microtubule stabilizer.
SGTC_2297 7971671 152.32 µM 0.167555099031909 0.429912642088169 no 1410 0.433466648735133 2079 909016
SGTC_970 1315-0089 19.5 µM 0.165363146518195 0.430863470338468 no 1411 0.434329079554926 2094 6811083 YLR033W RSC58
SGTC_1347 1493-0251 600 nM 0.163544006408948 0.431652884163409 no 1412 0.435045063715211 2104 3986378
SGTC_2192 5915882 198.485 µM 0.162531231135562 0.432092495386512 no 1413 0.435443768170795 2091 2876149
SGTC_1780 st038448 24.544 µM 0.161865749050457 0.432381404293266 no 1414 0.435705787687376 2077 728868 YDL195W SEC31
SGTC_2571 chrysanthemic acid 100 µM 0.160498976394396 0.432974881041895 no 1415 0.436244013946738 1931 2743 An insecticide.
SGTC_3158 9100007 49.47 µM 0.160318419418818 0.433053293394958 no 1416 0.436315124970625 1979 19297233
SGTC_1819 st053448 58.6 µM 0.159828726506767 0.433265970681651 no 1417 0.436507997242723 2034 2857616
SGTC_192 3455-0609 60.9 µM 0.158463845706854 0.433858850420638 no 1418 0.437045653806313 2050 3769639
SGTC_846 0335-0850 148 µM 0.158346487354409 0.433909835751832 no 1419 0.437091889286053 2118 6819598
SGTC_2962 9082311 13.18 µM 0.156172047010941 0.434854700786646 no 1420 0.437948704806297 2021 16459453
SGTC_2843 9000894 45.46 µM 0.155929498951013 0.434960118976055 no 1421 0.438044296451077 2127 2242070
SGTC_1922 5578187 25 µM 0.155721848305255 0.435050373444327 no 1422 0.438126137400675 2124 1350412
SGTC_2239 6685329 187.64 µM 0.155652722011041 0.435080419644555 no 1423 0.438153382601353 1995 805680
SGTC_1689 st020265 53.493 µM 0.155560752070273 0.435120395567716 no 1424 0.43818963177304 2131 5758320 YPR016C TIF6
SGTC_2460 5552655 174.22 µM 0.155156510365947 0.435296112305826 no 1425 0.438348966355755 1987 5401989
SGTC_387 norethindrone acetate 66.7 µM 0.152179403168402 0.436590599629643 no 1426 0.439522719318509 2007 541197
SGTC_2775 cyproheptadine 69.59 µM 0.150230746656635 0.437438271135118 no 1427 0.440291284419103 2151 2913 A selective serotonin reuptake inhibitor.
SGTC_1562 morin hydrate 59.1 µM 0.149447860515534 0.437778910086994 no 1428 0.440600124252853 2045 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_866 0495-0101 262 µM 0.149031879171996 0.437959925106079 no 1429 0.440764238957572 1924 635694
SGTC_1277 0873-0036 22 µM 0.148862668489769 0.438033561151174 no 1430 0.440830999578479 2110 5965735
SGTC_2924 9010168 62.78 µM 0.148114336966755 0.438359241070869 no 1431 0.441126267489935 2032 2993929
SGTC_2779 methotrexate 400 µM 0.144950562936699 0.439736599855639 no 1432 0.442374952252628 2150 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3073 9114972 49.47 µM 0.144892015784048 0.439762095467576 no 1433 0.442398065197263 2170 41905075
SGTC_3350 9150499 3.57 µM 0.143478580159875 0.440377681865634 no 1434 0.442956113385634 2147 4910996 YPR165W RHO1
SGTC_228 caffeine 993.056 µM 0.143215159032459 0.440492424302524 no 1435 0.443060129028285 2175 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_128 0906-2981 13.371 µM 0.142789823474973 0.440677704869597 no 1436 0.443228087206226 2156 6740226
SGTC_2658 polymyxin b sulfate 77.05 µM 0.142555310930223 0.440779866516238 no 1437 0.44332069680697 2076 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1836 st055642 81 µM 0.141186633068905 0.441376187593577 no 1438 0.443861252781347 1970 8571
SGTC_458 nppb 133 µM 0.140691245679765 0.441592056416442 no 1439 0.444056930619747 2170 4549 A chloride channel blocker.
SGTC_2725 haloperidol 53.21 µM 0.140387723190687 0.441724327225795 no 1440 0.444176828633562 2147 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_154 3389-1638 511.116 µM 0.139782871458944 0.4419879324237 no 1441 0.444415773505286 1904 5238686
SGTC_2235 salicylic acid 500 µM 0.139040053984332 0.442311700698822 no 1442 0.444709248964295 2170 338 A COX inhibitor and kinase inhibitor.
SGTC_2211 7117706 200 µM 0.138792322637811 0.442419686747542 no 1443 0.44480713045706 2167 822771
SGTC_459 nigericin 15.3 µM 0.138543333488631 0.442528225383204 no 1444 0.444905512313268 2080 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_977 1348-1378 135 µM 0.137817559202984 0.44284462741241 no 1445 0.445192303274575 2156 X977
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.137536779361232 0.442967043457019 no 1446 0.445303261617625 2147 6710655
SGTC_2154 5570129 200 µM 0.136739513670221 0.443314669675416 no 1447 0.445618347735743 2155 673366
SGTC_345 1362-0200 395 µM 0.136462427696794 0.443435495777499 no 1448 0.445727862500975 2002 1419823
SGTC_1932 st074806 40.9 µM 0.135213892211323 0.443979997206397 no 1449 0.446221381783936 2094 17251235
SGTC_2707 st078556 66.6 µM 0.134396689120682 0.444336446692867 no 1450 0.446544449791632 2188 17250899
SGTC_2446 5162541 200 µM 0.132581979931339 0.445128151237538 no 1451 0.447261992262273 2068 1549321
SGTC_20 0481-0013 4.944 µM 0.131670080968378 0.445526068924195 no 1452 0.447622625682691 2083 182045
SGTC_865 0488-0499 301 µM 0.129797507904346 0.44634335952802 no 1453 0.44836331732009 2206 9634651
SGTC_1319 1306-0155 43.7 µM 0.12968536591362 0.446392311534801 no 1454 0.448407680546344 2116 3122360
SGTC_1792 st045773 43.6 µM 0.129233808980217 0.446589432562182 no 1455 0.448586322408099 2056 2919270
SGTC_1145 3546-0597 10.2 µM 0.128446851604426 0.446932999598924 no 1456 0.448897677991068 2086 875334
SGTC_497 capsazepine 133 µM 0.128327995202845 0.446984892970183 no 1457 0.448944705647155 2049 2733484 A calcium channel blocker.
SGTC_728 3030-5151 22.5 µM 0.127558559089562 0.447320855010746 no 1458 0.449249164098058 2116 3125388
SGTC_1936 st074407 74.3 µM 0.127499945446959 0.44734644927806 no 1459 0.449272358178436 2051 809813
SGTC_2190 6049624 200 µM 0.127340720315273 0.447415977723332 no 1460 0.449335366236151 2158 2265554
SGTC_533 1222-0222 6.71 µM 0.127238420825498 0.447460649441808 no 1461 0.44937584853586 2177 3982874
SGTC_41 0478-0632 82.643 µM 0.126843809453536 0.447632972944036 no 1462 0.449532010414073 2208 3750424
SGTC_575 k072-0246 11.9 µM 0.126469610945313 0.447796391450082 no 1463 0.449680101410743 2146 6796779
SGTC_999 SEC7.066 22.7 µM 0.126352464142437 0.447847553165301 no 1464 0.449726464305842 2093 740511 YDR170C SEC7
SGTC_344 k064-0035 6.43 µM 0.12628013233898 0.447879143185665 no 1465 0.449755091224222 2006 5088750
SGTC_2119 5528445 120.635 µM 0.126037436382321 0.447985140056669 no 1466 0.449851145451331 2145 791935
SGTC_834 0312-0008 75.7 µM 0.124677202283577 0.448579287534064 no 1467 0.450389553246975 2172 6385573 YIL048W NEO1
SGTC_2666 tannic acid 100 µM 0.124465636357186 0.44867170949816 no 1468 0.450473303492666 2165 16134267 A thiamine antagonist.
SGTC_256 clotrimazole 625 nM 0.124181461261584 0.448795854950958 no 1469 0.450585800191001 2177 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2977 9011197 71.43 µM 0.124014921755186 0.448868612152866 no 1470 0.45065173020873 2164 2704722
SGTC_2405 ticlatone 3.52 µM 0.123217707328197 0.449216920201275 no 1471 0.450967351998628 2223 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_85 0868-0259 160.055 µM 0.121425158451778 0.450000238726936 no 1472 0.451677145374458 2123 83173
SGTC_3062 9077494 49.47 µM 0.118829201128677 0.451134980007904 no 1473 0.452705336716 2151 16459633
SGTC_1045 1348-1485 165 µM 0.11854392933009 0.451259702150155 no 1474 0.452818344942633 2188 6810614
SGTC_2585 alliin 100 µM 0.117326968971313 0.451791816714541 no 1475 0.453300477234293 2143 87310 A garlic compound which reacts with lipids.
SGTC_2090 5301565 104.445 µM 0.117202503404923 0.451846244043813 no 1476 0.453349791581615 2107 2056344
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.116000227691528 0.452372031527997 no 1477 0.453826180671388 2126 2724278 An inhibitor of dopamine biosynthesis.
SGTC_433 pimozide 108 µM 0.115835473530822 0.452444089479283 no 1478 0.45389146796414 2108 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1000 4048-0884 8.67 µM 0.11466468685598 0.452956197331519 no 1479 0.454355452532328 2121 13040088
SGTC_927 2425-1185 123 µM 0.113472606772342 0.453477699423706 no 1480 0.454827939710249 2168 730375
SGTC_2434 5670830 169.91 µM 0.112851535385014 0.45374943283944 no 1481 0.455074129970962 2113 1549830
SGTC_3091 9116372 49.47 µM 0.112508197948031 0.453899660387432 no 1482 0.455210234995999 2124 17169793
SGTC_2546 rhodinyl acetate 100 µM 0.11244728162308 0.453926315059783 no 1483 0.455234383852909 2217 6708682
SGTC_648 0375-0473 33.3 µM 0.11234581026249 0.45397071553757 no 1484 0.455274610175477 2124 1713139
SGTC_409 arachidonic acid 100 µM 0.112150322494658 0.454056256075789 no 1485 0.455352108743561 2208 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2641 levomentholum 100 µM 0.111873662339426 0.454177319253721 no 1486 0.455461789945848 2196 16666
SGTC_2103 5378138 10 µM 0.111454338049267 0.454360818665026 no 1487 0.45562803644438 2194 244142
SGTC_1919 st067113 52.3 µM 0.11080176302397 0.45464640968541 no 1488 0.455886773635736 2118 1268243
SGTC_945 3381-0768 11.3 µM 0.110236365504509 0.454893867560257 no 1489 0.456110961253341 2208 1126236 YIL048W NEO1
SGTC_1996 st072960 66.8 µM 0.108842999239625 0.455503777545544 no 1490 0.456663508966057 2240 1719405
SGTC_949 1165-0505 146 µM 0.108048886305566 0.455851426924793 no 1491 0.456978456751643 2108 6244267
SGTC_425 3825-7017 13.1 µM 0.107845809246855 0.45594033610764 no 1492 0.457059002123945 2151 3397440
SGTC_428 3448-4153 16.5 µM 0.106934992372041 0.456339127990214 no 1493 0.457420276222143 2036 3834874
SGTC_1467 k284-1082 293 µM 0.106903453659282 0.456352937684226 no 1494 0.457432786635604 2240 3334705
SGTC_1223 0764-0573 147 µM 0.105713036849739 0.456874217773992 no 1495 0.457905018201888 2188 1609797
SGTC_708 3448-5400 146 µM 0.105535861532536 0.456951808701564 no 1496 0.45797530773778 2227 3462195
SGTC_2390 9097792 176.6 µM 0.105463730948486 0.456983397538688 no 1497 0.458003923981153 2047 4497149
SGTC_567 1080-0542 68.4 µM 0.104792070493822 0.457277557254156 no 1498 0.458270401117467 2220 5950415
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.102334016500611 0.458354282408743 no 1499 0.459245777882431 2178 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1230 0170-0365 3.77 µM 0.101750443702859 0.458609955635277 no 1500 0.459477380801336 2222 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_747 3448-8087 38.7 µM 0.100880049886821 0.458991321841445 no 1501 0.459822840094875 2144 5168703
SGTC_2365 9042475 200 µM 0.0999279673484624 0.459408523469239 no 1502 0.460200756370459 2124 6464479
SGTC_2391 6285546 200 µM 0.099075414377081 0.459782149292152 no 1503 0.460539196256492 2189 846083
SGTC_224 benfluorex 43.875 µM 0.0982082572995893 0.460162211705434 no 1504 0.460883462893195 2231 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1931 st074438 57.1 µM 0.0976045813928994 0.460426815641896 no 1505 0.461123143227201 2232 2787313
SGTC_1764 st044502 93.5 µM 0.0974669653677724 0.460487138117675 no 1506 0.461177783556004 2147 8407
SGTC_1407 3909-7909 12.3 µM 0.0971906569500988 0.460608257627558 no 1507 0.461287493796405 2180 4411780
SGTC_1199 1638-0010 4.46 µM 0.0952783494763375 0.461446615208908 no 1508 0.46204686951236 2129 3111136
SGTC_3127 9126946 49.47 µM 0.0936652197437703 0.462153946349429 no 1509 0.4626875496996 2076 27243249
SGTC_2649 anisomycin 9.56 µM 0.0932831657064591 0.462321488444893 no 1510 0.46283930279169 2173 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_879 0831-1030 162 µM 0.0932443185415731 0.462338524460796 no 1511 0.462854733313786 2226 1549252
SGTC_1673 st016611 27.3 µM 0.0932032482599084 0.462356535476331 no 1512 0.462871046943153 2191 5226799
SGTC_1658 st012944 20 µM 0.0931644698741698 0.462373541471645 no 1513 0.462886450260121 2209 24207260
SGTC_3249 9135183 49.47 µM 0.0931543346219813 0.462377986228374 no 1514 0.462890476133163 2193 4902779
SGTC_3336 9143619 71.43 µM 0.0927857125501591 0.462539646512344 no 1515 0.463036900887192 2247 45595730
SGTC_2905 7799065 20.05 µM 0.0925654956711473 0.462636226220668 no 1516 0.463124378241804 2243 1296806
SGTC_554 4483-2211 187 µM 0.0923286224845193 0.462740113283453 no 1517 0.463218474017649 2154 747107
SGTC_1647 st011722 22.4 µM 0.0919783299743244 0.462893748076104 no 1518 0.463357628385779 2217 2854783
SGTC_342 k048-0088 23.3 µM 0.0911758642273027 0.463245722356943 no 1519 0.463676426307902 2212 6820570
SGTC_1420 4'-methoxyflavone 42 µM 0.0901753326641823 0.463684611737865 no 1520 0.464073943066906 2244 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2786 7743617 45.45 µM 0.0885975399668785 0.464376809901238 no 1521 0.464700881610132 2140 583674
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.0885855224617722 0.464382082553364 no 1522 0.464705657123992 2208 688669
SGTC_1324 1418-0026 34.4 µM 0.0880362181098574 0.464623095209435 no 1523 0.464923944997509 2158 1372513
SGTC_1403 3909-7815 62.9 µM 0.087356046397624 0.464921545177296 no 1524 0.465194252828987 2177 6615483
SGTC_3119 9125183 49.47 µM 0.0872188423150894 0.464981750834057 no 1525 0.46524878121378 2251 22695334
SGTC_2312 7706453 155.7 µM 0.0865953253424081 0.465255362457291 no 1526 0.465496590889886 2182 976098
SGTC_2035 5154463 94.595 µM 0.0865409167602958 0.465279238804154 no 1527 0.465518215593515 2230 2769623
SGTC_3266 9136860 49.47 µM 0.0863964139396766 0.46534265219114 no 1528 0.46557564876737 2252 4871271 YPR165W RHO1
SGTC_2832 7992762 51.95 µM 0.0837994754776085 0.466482437006868 no 1529 0.466607932531343 2080 2985177
SGTC_537 1334-0398 209 µM 0.0837016926578582 0.466525358883938 no 1530 0.466646805661896 2281 5846986
SGTC_274 sirtinol 40.1 µM 0.0835987709794925 0.466570536889223 no 1531 0.466687722066797 2092 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1721 st082152 9.2685 µM 0.0827057141215888 0.466962566857036 no 1532 0.467042770614987 2263 5296051
SGTC_1255 0566-0045 221 µM 0.0816739509180177 0.467415525375789 no 1533 0.467452996646541 2177 2788469
SGTC_1620 st003704 16.5 µM 0.0810647638507508 0.467682986893242 no 1534 0.467695223901849 2245 2834414
SGTC_2567 aureobasidin a 60 nM 0.0800840479522737 0.46811359748458 no 1535 0.468085204942084 2154 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2329 6138490 200 µM 0.0796705840524635 0.468295151519359 no 1536 0.468249627793789 2132 720019
SGTC_658 3253-0951 102 µM 0.0788238647168516 0.468666970688289 no 1537 0.468586360901943 2196 1184878
SGTC_1342 1486-1464 234 µM 0.0783335242244858 0.468882306025182 no 1538 0.468781375454327 2275 3253938
SGTC_667 1498-1044 59 µM 0.0782991652553649 0.468897395270335 no 1539 0.46879504072786 2187 6739982
SGTC_2399 5884133 200 µM 0.0781321730890006 0.468970732964921 no 1540 0.468861457493787 2195 722445
SGTC_1358 1509-0022 2.48 µM 0.077223591667758 0.469369771663326 no 1541 0.469222837123393 2202 3258434
SGTC_1450 4112-4260 37.6 µM 0.0767247879711182 0.469588853721201 no 1542 0.469421242355972 2264 1633175
SGTC_941 3237-0776 460 µM 0.075990324594555 0.469911457782562 no 1543 0.469713397898079 2249 760008
SGTC_2219 9098279 200 µM 0.0758586252937937 0.469969307185243 no 1544 0.469765787100139 2280 902349
SGTC_2952 9073731 13.78 µM 0.0754453179303834 0.470150858076434 no 1545 0.469930201716637 2217 16457353
SGTC_1866 st057638 64 µM 0.0725757987997589 0.471411502492402 no 1546 0.471071842840617 2214 688802
SGTC_2123 5259487 200 µM 0.0720949466018993 0.471622780068861 no 1547 0.471263173894881 2266 2173474
SGTC_1700 st030840 7.9285 µM 0.0715772207188144 0.471850268188318 no 1548 0.471469184399994 2285 5499307
SGTC_462 ag-879 158 µM 0.0715737359325014 0.471851799430359 no 1549 0.471470571072045 2273 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2643 anethole 100 µM 0.0714331852692572 0.471913558824708 no 1550 0.471526499517267 2259 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2950 9072895 21.46 µM 0.0712187517559591 0.472007784397269 no 1551 0.471611828783812 2201 17332245
SGTC_2700 st077718 96.8 µM 0.0673911159285673 0.473689968429131 no 1552 0.473135170786867 2210 904970
SGTC_2195 6536160 144.242 µM 0.0671113034637266 0.47381296025074 no 1553 0.473246547660823 2271 3834386
SGTC_2097 5376186 200 µM 0.0662315852831174 0.474199657377714 no 1554 0.473596725277093 2279 742755
SGTC_1491 4138-0063 26.5 µM 0.0658134576779709 0.474383461992402 no 1555 0.473763170894565 2299 23883227
SGTC_499 genistein 192 µM 0.0657177873883455 0.474425518440272 no 1556 0.473801255369036 2293 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_758 0868-0029 16 µM 0.065150541899456 0.474674884142216 no 1557 0.47402706963052 2306 762687
SGTC_1529 apigenin 74 µM 0.0631964480026654 0.475533994967876 no 1558 0.474805036605525 2285 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1806 st050005 60.3 µM 0.0627036336534674 0.475750677262541 no 1559 0.475001251926449 2206 5194765
SGTC_3139 9095020 49.47 µM 0.0626130552843584 0.47579050385103 no 1560 0.475037316601845 2306 25236292
SGTC_885 0865-0106 16.8 µM 0.0623793719826719 0.475893253656164 no 1561 0.475130360868295 2264 2793380
SGTC_881 0833-0569 170 µM 0.0621788253637328 0.475981434645645 no 1562 0.475210212383904 2151 5418700
SGTC_2989 9073649 71.4286 µM 0.0620383576578774 0.476043199445754 no 1563 0.475266142911291 2308 21367202
SGTC_3269 9137823 49.47 µM 0.0620056447245056 0.476057583673031 no 1564 0.475279168406647 2214 17682936
SGTC_1448 4255-0083 152 µM 0.0610302057069935 0.47648650891281 no 1565 0.475667576604828 2304 5399660
SGTC_972 1319-0219 195 µM 0.0608062446997807 0.476584994103575 no 1566 0.475756758487633 2215 23903702
SGTC_746 1095-0025 46.6 µM 0.0602190077814635 0.476843233956557 no 1567 0.475990603583022 2287 6749286
SGTC_1691 st019933 84.6 µM 0.0598579085161833 0.477002033681004 no 1568 0.476134401943923 2308 6176082
SGTC_1881 5652484 16 µM 0.0596897003318339 0.477076007423632 no 1569 0.476201387526885 2295 2255129
SGTC_1361 1608-0041 5.61 µM 0.0585239239969973 0.477588708200847 no 1570 0.476665653278418 2277 X1361
SGTC_2557 derrustone 83.84 µM 0.0573576838306192 0.478101650085621 no 1571 0.477130135443807 2137 629853 An antioxidant.
SGTC_1181 1222-0449 220 µM 0.0568290418453643 0.478334172184176 no 1572 0.477340689633968 2280 658318
SGTC_2328 6201408 200 µM 0.056780262501105 0.478355628052066 no 1573 0.477360118405427 2242 2890418
SGTC_1887 st057648 70.8 µM 0.0550741510184302 0.47910610977142 no 1574 0.478039694689968 2307 688672
SGTC_406 estrone 100 µM 0.0537711682122301 0.479679313897572 no 1575 0.478558740354452 2320 5870 A steroid.
SGTC_2916 7875993 68.79 µM 0.0535033834673959 0.479797122170983 no 1576 0.478665417447748 2317 1299250
SGTC_1406 3909-7906 11.9 µM 0.0533528123827125 0.479863364657164 no 1577 0.478725400945156 2309 X1406
SGTC_1785 bathophenanthroline 24 µM 0.0532404277605058 0.479912807691927 no 1578 0.478770172290253 2207 72812 An iron chelator.
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.0530713427935488 0.479987196332904 no 1579 0.478837532200882 2316 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2199 6590217 200 µM 0.0530242097306419 0.480007932567362 no 1580 0.478856309134113 2275 703109
SGTC_1136 pergolide 1.05886 µM 0.0529597414724108 0.480036295524578 no 1581 0.478881992161843 2211 47811 A dopamine receptor agonist.
SGTC_510 ag-490 170 µM 0.0521432376277424 0.480395526951476 no 1582 0.47920728058046 2307 5328779
SGTC_115 0527-0192 112.043 µM 0.05167673376066 0.480600778527395 no 1583 0.479393138116369 2176 4233931
SGTC_3271 9137798 49.47 µM 0.0513503021674399 0.480744404404956 no 1584 0.47952319280613 2310 6498326
SGTC_911 3456-4043 236 µM 0.0508170404242858 0.480979038367909 no 1585 0.479735656062711 2279 914281
SGTC_2697 mebhydrolin 72.4 µM 0.0504657030220269 0.481133629637689 no 1586 0.479875639793772 2301 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_956 1185-0240 191 µM 0.0496437888293648 0.481495289504549 no 1587 0.480203125595633 2284 1416193
SGTC_2139 5578692 56.4705 µM 0.0490071085068895 0.481775452980738 no 1588 0.480456815489557 2329 650991 YMR113W FOL3
SGTC_3100 9120536 49.47 µM 0.0483341573261548 0.482071586791096 no 1589 0.480724966372987 2336 16421196
SGTC_2774 tamoxifen 10.92 µM 0.0481515343312764 0.482151952199302 no 1590 0.480797737674674 2314 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1833 st055984 71 µM 0.0462467325818542 0.482990225352822 no 1591 0.481556797541687 2227 676288
SGTC_2363 9053361 176 µM 0.0461196220414763 0.483046167410778 no 1592 0.481607453260246 2317 6469797 YMR079W SEC14
SGTC_2406 ethylparaben 405.7 µM 0.0453389539414291 0.483389751075395 no 1593 0.481918569296385 2206 8434 A possible steroid mimic.
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.044520760867102 0.483749863274635 no 1594 0.482244651801934 2328 65057 A dermal irritant. YDR527W RBA50
SGTC_2553 4-methylesculetin 85.09 µM 0.0444532749604645 0.483779566515207 no 1595 0.482271548155029 2324 5319502
SGTC_1820 st053765 18.6 µM 0.0444122554160751 0.483797620897597 no 1596 0.482287896439671 2276 3690829
SGTC_2073 5212005 126 µM 0.0442425091530023 0.483872333536622 no 1597 0.482355548902478 2327 691789
SGTC_500 h-89 112 µM 0.0440890049901357 0.483939897815673 no 1598 0.482416728505198 2323 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2115 tiliquinol 12.7705 µM 0.0434464996622748 0.484222699097633 no 1599 0.482672805651207 2283 71208 A bioactive hydroxyquinoline.
SGTC_996 3970-0799 1.8 µM 0.0429842451327442 0.484426167189352 no 1600 0.482857046404251 2283 6615648 YGL040C HEM2
SGTC_2142 5622915 118.518 µM 0.0428365378893655 0.484491183550227 no 1601 0.482915918842784 2299 5322196
SGTC_1456 k015-0012 13 µM 0.0425308788847935 0.484625726913312 no 1602 0.483037748111746 2345 2989616
SGTC_1215 3852-0577 11.2 µM 0.0418814751114788 0.484911583820577 no 1603 0.483296592079403 2320 2884876
SGTC_194 1486-1323 56.904 µM 0.0411335482032191 0.48524081859765 no 1604 0.483594714814286 2299 5178754
SGTC_86 0417-1630 471.922 µM 0.0406570875171371 0.485450560165355 no 1605 0.483784636243832 2329 3634867
SGTC_2720 fluspirilene 36.88 µM 0.0405233090371232 0.485509451181916 no 1606 0.48383796218862 2325 3396 An atypical antipsychotic.
SGTC_1999 st074831 12.5 µM 0.040432877150471 0.485549260646745 no 1607 0.483874009748059 2223 17112523
SGTC_116 0155-0182 31.788 µM 0.0395209082044029 0.485950730956591 no 1608 0.48423754210041 2236 771486
SGTC_3211 9128781 49.47 µM 0.0391211868215052 0.486126702280517 no 1609 0.484396884628433 2179 17194361
SGTC_3220 9131269 49.47 µM 0.038148746826684 0.486554815567324 no 1610 0.484784542613354 2355 17722206
SGTC_1102 cgs 12066b 26.1 µM 0.0380245034332124 0.486609514410925 no 1611 0.484834072619117 2270 6438352 A 5-HT1B full agonist.
SGTC_2403 6032726 181.2 µM 0.0380025707576197 0.486619170419285 no 1612 0.484842816171107 2301 2881040
SGTC_2307 7538926 6.34 µM 0.0373336754478666 0.486913659832093 no 1613 0.485109477538 2282 96582
SGTC_1312 1218-2183 165 µM 0.0363587473096098 0.48734289670989 no 1614 0.485498153645994 2341 6744073
SGTC_1622 st003707 19.4 µM 0.0359569999802073 0.48751978047113 no 1615 0.485658322904436 2276 10140899
SGTC_2872 9044037 25.97 µM 0.0354299761159936 0.487751825465503 no 1616 0.485868441113646 2262 6465195
SGTC_1668 st014914 51.6 µM 0.0348439517381181 0.48800985284685 no 1617 0.486102086737287 2331 2839556
SGTC_3081 9117243 49.47 µM 0.0345432573845104 0.488142250960841 no 1618 0.486221974255175 2328 45595589
SGTC_526 4469-0568 170 µM 0.0343909463481999 0.488209315220311 no 1619 0.486282701485156 2339 2901964
SGTC_507 nimesulide 162 µM 0.0333959246311808 0.488647442571882 no 1620 0.486679429762406 2342 4495 A COX2 inhibitor.
SGTC_2811 7967822 32.47 µM 0.0329224616098012 0.488855922361625 no 1621 0.48686821036438 2331 2232244
SGTC_1054 3429-0080 167 µM 0.0328390869655385 0.488892635003536 no 1622 0.48690145405959 2338 1162877
SGTC_2286 7945697 125 µM 0.0328153026033505 0.488903108070252 no 1623 0.486910937536087 2309 1245733
SGTC_2582 agaric acid 100 µM 0.0322320745604846 0.489159925666631 no 1624 0.487143488830423 2327 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_665 3914-0008 307 µM 0.031402301178244 0.48952531431828 no 1625 0.487474352991444 2342 1069549
SGTC_1174 0739-0097 51.1 µM 0.0312705258786103 0.489583342061582 no 1626 0.487526897924812 2322 728447
SGTC_806 3966-4455 5.86 µM 0.0295046848688937 0.490360957501798 no 1627 0.488231041292246 2233 714982
SGTC_1475 4092-1048 11.7 µM 0.0294764095035539 0.490373409302802 no 1628 0.488242316626871 2273 2881759
SGTC_2938 9059746 27.26 µM 0.0281761628942079 0.490946017043241 no 1629 0.488760824464737 2329 6471769
SGTC_2303 7774051 200 µM 0.0279873406730572 0.491029172898788 no 1630 0.488836123936258 2343 2953184
SGTC_2703 st077852 53.4 µM 0.0273047026936779 0.49132980464692 no 1631 0.489108353030586 2328 6281836
SGTC_1002 4049-0206 172 µM 0.0268949759751088 0.491510249458716 no 1632 0.489271750330279 2348 4662749
SGTC_1217 1183-1422 255 µM 0.0254391372901231 0.492151418754815 no 1633 0.489852347078271 2342 2849664
SGTC_2969 9091408 28.7 µM 0.0254348087154561 0.492153325143493 no 1634 0.489854073371139 2262 4286311
SGTC_2996 9066192 71.4286 µM 0.0240344459879603 0.492770081354303 no 1635 0.490412566355778 2339 6472854
SGTC_1268 0828-0275 2.46 µM 0.0236384499646805 0.49294449151354 no 1636 0.490570501037562 2348 745337
SGTC_3228 9131799 49.47 µM 0.0234704270020531 0.493018494968382 no 1637 0.490637513909017 2315 17015818
SGTC_487 nimodipine 119 µM 0.0234334494410791 0.493034781270303 no 1638 0.490652261765345 2370 4497 L-type voltage-gated calcium channels inhibitor
SGTC_450 aminopyrene 156 nM 0.0224665476180086 0.493460645064513 no 1639 0.49103789819735 2363 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2507 purpurin 79.67 µM 0.0223675436273614 0.493504250970244 no 1640 0.491077385152315 2376 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2471 5466956 24.79 µM 0.021927309228838 0.493698151356456 no 1641 0.491252970197496 2301 724419
SGTC_1026 k007-1105 30.6 µM 0.0219102016169251 0.493705686401264 no 1642 0.49125979350794 2370 7066794
SGTC_3098 9119039 49.47 µM 0.0215873151016639 0.493847902131131 no 1643 0.491388576128851 2369 17161528
SGTC_2082 5219693 150 µM 0.02154023779279 0.493868637450673 no 1644 0.491407352891735 2368 2834649
SGTC_2441 5730946 39.09 µM 0.0214117046033726 0.493925250302634 no 1645 0.491458618391761 2352 1774275
SGTC_1832 st054113 55 µM 0.0213201343475388 0.493965582787671 no 1646 0.491495141301076 2371 1251267
SGTC_1502 4534-4282 27.7 µM 0.0211227233837841 0.494052533444684 no 1647 0.491573879149251 2359 3278949
SGTC_1928 4'-methoxychalcone 40.3 µM 0.0207583905769341 0.494213006410291 no 1648 0.491719195044731 2373 641818
SGTC_2984 9022109 38.96 µM 0.020179887891526 0.494467813929616 no 1649 0.491949935878435 2374 6459207
SGTC_2958 9077254 16.72 µM 0.0199952890574576 0.494549122884356 no 1650 0.492023565301506 2337 16457351
SGTC_638 3970-0837 4.09 µM 0.0194483975633591 0.494790009664305 no 1651 0.492241701012388 2358 4118451 YLR208W SEC13
SGTC_3135 9127742 49.47 µM 0.0193486285508936 0.494833954669629 no 1652 0.492281495601615 2315 3643468
SGTC_2884 9058502 51.95 µM 0.0191508606015949 0.494921065204313 no 1653 0.492360378981593 2351 6471554
SGTC_2428 5615643 7.78 µM 0.0186201983399388 0.495154806353556 no 1654 0.492572044841818 2349 2253075
SGTC_1079 idarubicin 2.36 µM 0.0186048327152003 0.495161574485379 no 1655 0.492578173777489 2370 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_472 calcifediol 10 µM 0.0184616492940788 0.495224642880603 no 1656 0.492635285888672 2315 5283731 A vitamin D metabolite.
SGTC_1612 st002233 45.4 µM 0.0179241649321438 0.495461391147528 no 1657 0.492849675640626 2368 1035021
SGTC_2019 4016004 108 µM 0.0176343375153951 0.495589053462743 no 1658 0.492965281777686 2356 45595336
SGTC_1603 st002045 67.8 µM 0.0174766599571889 0.49565850699338 no 1659 0.493028176329602 2377 5887985
SGTC_1954 st077032 68.9 µM 0.0170610315070663 0.495841582899609 no 1660 0.49319396336833 2236 698907
SGTC_1526 st051518 75 µM 0.0161438683645081 0.496245577714004 no 1661 0.493559808086662 2310 673993
SGTC_978 1416-0512 87.4 µM 0.0152531357068916 0.496637934037251 no 1662 0.493915115208407 2358 6814003
SGTC_378 3970-0959 8.33 µM 0.013916754141578 0.497226598975647 no 1663 0.494448197576075 2366 6615653
SGTC_383 2324-0395 7.37 µM 0.0137914200673533 0.497281807920052 no 1664 0.49449819383916 2360 3146421
SGTC_1078 idebenone 36.1 µM 0.0132350512762647 0.497526885811121 no 1665 0.494720132605788 2353 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_3076 9116187 49.47 µM 0.0127705205042151 0.497731510196474 no 1666 0.494905437903969 2370 27241210
SGTC_1370 2001-0092 44.6 µM 0.012567866734711 0.497820778752719 no 1667 0.494986278572702 2359 790957
SGTC_1404 3909-7820 48.3 µM 0.0125156541375006 0.497843778309061 no 1668 0.49500710674714 2378 23741373
SGTC_590 k048-0076 22.4 µM 0.0124106864479645 0.497890016411489 no 1669 0.495048979544363 2381 6832814
SGTC_2022 5136654 200 µM 0.0123493537692663 0.497917033373314 no 1670 0.495073445868076 2371 1713771
SGTC_309 k408-0051 1.48 µM 0.0119186324648566 0.498106765786138 no 1671 0.495245266156805 2373 3640463
SGTC_1313 1220-0047 237 µM 0.0115793622617848 0.498256214360776 no 1672 0.495380606043232 2369 3528706
SGTC_2187 6125751 200 µM 0.0106285711582542 0.498675039219262 no 1673 0.495759893416552 2350 874498
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.0104659885034584 0.498746657273206 no 1674 0.495824750903899 2382 75037 A free radical scavenger.
SGTC_262 fenpropimorph 62.5 µM 0.0100290603088569 0.498939125396837 no 1675 0.495999050880825 2388 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_861 0443-0273 110 µM 0.00866057151672888 0.499541950028917 no 1676 0.496544975040569 2347 6149169
SGTC_3348 9149464 3.537 µM 0.00823894743713864 0.499727677349497 no 1677 0.496713172706475 2391 1951442
SGTC_628 1636-0253 16 µM 0.00817421374439969 0.499756192841172 no 1678 0.496738996843854 2389 4456143
SGTC_3052 9092717 49.47 µM 0.0070672691008253 0.499756192841172 no 1679 0.497180591018563 2384 25237534
SGTC_2835 9006588 71.43 µM 0.00538662465774185 0.499015862002586 no 1680 0.497851058067564 2382 2345538
SGTC_1351 1496-0003 46.5 µM 0.00412095902398284 0.498458333147069 no 1681 0.498355979862741 2396 3891978
SGTC_2949 9072542 2.23 µM 0.00407714127537748 0.498439031367617 no 1682 0.498373460468433 2393 16457352
SGTC_2630 antimycin a 100 µM 0.00244023833160597 0.497717976345211 no 1683 0.49902648672144 2399 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2344 7990960 76.95 µM 0.00232804988489423 0.497668557630275 no 1684 0.499071243308981 2397 140813
SGTC_1498 4478-3555 97.6 µM 0.00232121164920716 0.497665545406636 no 1685 0.499073971362948 2397 3437919
SGTC_1128 3448-9350 235 µM 0.00200182831648261 0.497524858095641 no 1686 0.499201386579833 2398 619386
SGTC_1790 st045711 43.5 µM 0.00199025513628481 0.497519760153379 no 1687 0.499206003601535 2401 585119
SGTC_2384 9036245 200 µM 0.00116748682935631 0.497157334902661 no 1688 0.499534240247765 2396 6462766
SGTC_1846 st056244 14.8 µM 0.00106882322964377 0.497113874240904 no 1689 0.499573601304605 2388 5393182
SGTC_2846 9008642 19.48 µM 0.000987356157052862 0.497077988561166 no 1690 0.499606101947137 2404 2992898
SGTC_2325 6158266 200 µM 0.000849241515457465 0.497017150074838 no 1691 0.499661201693936 2402 3623240
SGTC_1385 3091-4834 14.1 µM 0.000510415758547624 0.4968679001115 no 1692 0.499796373582174 2400 4072814
SGTC_2421 5690543 90.72 µM 0.000422965566391575 0.496829379090371 no 1693 0.499831261157444 2384 3397993
SGTC_2887 9044784 58.44 µM 0.000360231587711666 0.496801745356607 no 1694 0.499856288392034 2403 6465546
SGTC_2013 4024628 200 µM 0.000107419632107824 0.496690384199889 no 1695 0.499957145767089 2405 5230760
SGTC_2584 androsterone 48.74 µM 6.5908035286693e-05 0.496672098778004 no 1696 0.499973706498125 2405 2754130 A steroid.
SGTC_218 alverine citrate 93.75 µM 0 0.496643066995893 no 1697 0.5 2391 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0 0.496643066995893 no 1698 0.5 2405 5024745
SGTC_3310 9130229 44.1445 µM -0.00233353955331133 0.495615180464436 no 1699 0.499069053254092 2418 7761258
SGTC_2508 celastrol 40.54 µM -0.00251032428921889 0.495537310740486 no 1700 0.498998526555348 2411 122724 Celastrol is a natural product and antioxidant.
SGTC_19 0279-0214 38.434 µM -0.00317920861383426 0.495242683712843 no 1701 0.498731681402286 2410 3566274 YBR002C RER2
SGTC_2959 9079155 11 µM -0.00332760828799488 0.495177317667011 no 1702 0.49867247881124 2413 16189457
SGTC_2259 7964009 200 µM -0.00401302768165513 0.494875410655794 no 1703 0.498399037882454 2425 313134
SGTC_788 1182-0090 188 µM -0.00432062675410716 0.494739923287704 no 1704 0.49827632467283 2419 5715185
SGTC_104 0074-0074 590.992 µM -0.00469037026069862 0.494577064125808 no 1705 0.498128819853133 2413 3943124
SGTC_501 nsc-95397 161 µM -0.0056794763938159 0.494141401774224 no 1706 0.497734228916928 2422 262093
SGTC_2113 5491891 107.031 µM -0.00608423800148384 0.493963122190021 no 1707 0.497572755192464 2416 789979
SGTC_2634 4'-methoxyflavone 100 µM -0.007380164822036 0.493392332034812 no 1708 0.497055766943358 2424 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1029 k015-0030 64.7 µM -0.00750877645348812 0.493335685841206 no 1709 0.497004459747601 2460 2208316
SGTC_1021 4476-0760 85.3 µM -0.00760157499520764 0.493294813383753 no 1710 0.496967439542347 2421 746768
SGTC_379 3970-0972 5.9 µM -0.00857116247472792 0.492867769767751 no 1711 0.496580642763773 2428 2898042 YBL034C STU1
SGTC_200 k038-0079 37.545 µM -0.00880065989319112 0.49276669145639 no 1712 0.496489089994173 2433 3436683
SGTC_354 2783-3500 4.88 µM -0.00882304909345799 0.492756830531206 no 1713 0.496480158342335 2420 6740761
SGTC_2771 fluoxetine 41.05 µM -0.0098508545068364 0.492304156773628 no 1714 0.496070141197723 2431 3386 A selective serotonin reuptake inhibitor.
SGTC_2371 9071574 200 µM -0.010047507795616 0.492217546371039 no 1715 0.495991691769177 2428 45596039
SGTC_1634 st006576 41 µM -0.0100547059156446 0.492214376168733 no 1716 0.495988820279808 2432 3915356
SGTC_1771 st048882 4.1505 µM -0.0101693425168963 0.492163887883157 no 1717 0.495943089230841 2423 4580403
SGTC_1992 st073643 23.3 µM -0.0106571677300407 0.49194904117314 no 1718 0.495748485681091 2420 3161292
SGTC_2669 eugenol 100 µM -0.0126964440554258 0.491050934409043 no 1719 0.494934987735641 2421 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2361 9034121 116 µM -0.0136661480333282 0.49062388791 no 1720 0.494548165440519 2444 6496917
SGTC_2037 5169046 200 µM -0.0138534509460897 0.490541403080851 no 1721 0.494473449462886 2452 5718022
SGTC_2929 9013348 24.6 µM -0.0142655611996122 0.490359918577029 no 1722 0.49430905750819 2448 2995952
SGTC_2598 perillyl alcohol 100 µM -0.0146094643715303 0.490208472532933 no 1723 0.494171874291325 2445 10819 An apoptosis inducer.
SGTC_2179 6298986 200 µM -0.0164776424663078 0.48938580054252 no 1724 0.493426669197331 2449 738374
SGTC_386 1509-0011 3.07 µM -0.0177371178273337 0.488831202509528 no 1725 0.492924284777802 2441 3107280
SGTC_2788 5282734 71.43 µM -0.0181140038722451 0.488665248462496 no 1726 0.492773953155133 2459 743706
SGTC_3205 9113483 49.47 µM -0.0184647360049828 0.488510812517058 no 1727 0.492634054679056 2434 17018033
SGTC_1506 4226-2149 212 µM -0.0186756725064366 0.488417932838945 no 1728 0.492549917698977 2484 991114
SGTC_3029 9088683 49.47 µM -0.0193341100177736 0.488128013329675 no 1729 0.492287286575057 2466 25236615
SGTC_316 k060-0003 58.6 µM -0.0195127901692211 0.488049338964086 no 1730 0.492216016953298 2452 6152314
SGTC_1632 st005650 90 µM -0.0196489031254287 0.487989407602591 no 1731 0.492161726149003 2474 2759605
SGTC_3181 9108277 49.47 µM -0.0206701296442129 0.487539764107018 no 1732 0.491754398509118 2436 17097298
SGTC_1853 st056710 91.2 µM -0.0210851470163585 0.487357037484427 no 1733 0.49158886661306 2458 269167
SGTC_3126 9127922 49.47 µM -0.0215630853145166 0.48714661090655 no 1734 0.491398240165874 2497 45595682
SGTC_1756 st041558 35.5 µM -0.0218481821812508 0.487021090215547 no 1735 0.491284529761714 2442 3955792
SGTC_2347 9049783 174.81 µM -0.0224744887268615 0.486745348362671 no 1736 0.491034730952985 2459 6467988 YPL169C MEX67
SGTC_2246 7293507 91.5585 µM -0.0230827267430393 0.486477567543714 no 1737 0.490792142039132 2446 887656
SGTC_2141 5621638 7.665 µM -0.0234764395593474 0.486304236109254 no 1738 0.490635115906442 2479 2856238
SGTC_1761 st044296 37 µM -0.0240599270286359 0.486047361457189 no 1739 0.490402403830057 2444 1826700
SGTC_1393 3470-5649 58.2 µM -0.0241759908147468 0.485996266197337 no 1740 0.49035611454322 2479 4108395
SGTC_669 0108-0021 26.2 µM -0.0243510386707265 0.485919204561777 no 1741 0.490286301105709 2448 17201
SGTC_1164 k060-0068 93.7 µM -0.0249022443041156 0.485676549752926 no 1742 0.490066468547332 2446 5963676
SGTC_2679 rapamycin 1 nM -0.0255312755720358 0.48539964059534 no 1743 0.489815601157083 2457 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2635 hydroquinidine 100 µM -0.025705219681026 0.485323068982641 no 1744 0.489746230265274 2467 442912 An experimental heart treatment.
SGTC_1157 4092-0394 27.6 µM -0.0258710040793791 0.485250089844636 no 1745 0.489680113847663 2495 3659885
SGTC_2140 5586273 200 µM -0.0273864048989806 0.484583025876609 no 1746 0.489075770750952 2449 854421
SGTC_2377 9073351 62.6 µM -0.0275333529653363 0.484518343103001 no 1747 0.489017169052635 2456 7337946 YHR072W ERG7
SGTC_1594 piperine 70.1 µM -0.0275539678149447 0.484509269006956 no 1748 0.489008948036564 2457 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3163 9099914 49.47 µM -0.028572784675328 0.484060823627983 no 1749 0.488602658951152 2460 16268368
SGTC_2482 5981709 142.65 µM -0.0287455807518308 0.483984767190763 no 1750 0.48853375159473 2493 877755
SGTC_3123 9126162 49.47 µM -0.0290654172245981 0.483843992254892 no 1751 0.488406208597468 2463 25239884
SGTC_1967 st070177 51.4 µM -0.0291759126266223 0.4837953585466 no 1752 0.488362145996627 2481 5729214
SGTC_3285 9112818 20.8695 µM -0.0294267915676437 0.483684936990767 no 1753 0.488262102736305 2457 17017947 YPR165W RHO1
SGTC_2629 bisabolol 100 µM -0.0310632668882587 0.482964691791958 no 1754 0.487609542149875 2477 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_784 4579-0127 173 µM -0.0313126460697471 0.482854939897983 no 1755 0.487510102624395 2548 1948547
SGTC_2420 aureobasidin a 50 nM -0.0319506721075415 0.482574150275114 no 1756 0.487255694373673 2508 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2486 5283202 22.39 µM -0.0325067718923721 0.482329422717288 no 1757 0.487033957847959 2498 1377751
SGTC_2736 butenafine 14.65 µM -0.0331718826150382 0.482036730541455 no 1758 0.48676876010045 2497 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1191 1487-1166 10.6 µM -0.0333445055864373 0.481960766731135 no 1759 0.486699931575077 2534 3955771
SGTC_1940 st075990 51.1 µM -0.0335413659285369 0.481874137914843 no 1760 0.486621439567587 2646 1084979
SGTC_1364 1653-0028 37.6 µM -0.0345366350602239 0.481436180781975 no 1761 0.486224614604879 2508 5718652
SGTC_3235 9132602 49.47 µM -0.0351236029612196 0.481177902541713 no 1762 0.485990590290151 2534 4912240
SGTC_734 2023-0417 80 µM -0.0355324192980774 0.480998019403327 no 1763 0.485827597914151 2505 3935732
SGTC_1552 6-methylflavone 10.6 µM -0.0355595746499146 0.480986070922764 no 1764 0.485816771338112 2474 689013
SGTC_445 e6 berbamine 66 µM -0.0359089489660184 0.48083234613318 no 1765 0.485677480113927 2505 6610268 A calcium/calmodulin antagonist.
SGTC_2448 5185112 27.17 µM -0.0364889242273122 0.480577163172303 no 1766 0.485446255007901 2510 5718189
SGTC_2285 7945142 200 µM -0.0368914203291218 0.480400073830564 no 1767 0.485285790338893 2508 2970608
SGTC_2490 carminic acid 95.39 µM -0.037066083730935 0.480323227016082 no 1768 0.485216157348492 2468 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_710 3448-4187 58 µM -0.0372324350585872 0.480250037952237 no 1769 0.485149838548569 2483 3946412
SGTC_1427 4048-4900 550 nM -0.0394814069391951 0.479260631311448 no 1770 0.484253288535529 2499 24132586
SGTC_410 α-linolenic acid 100 µM -0.0400081177835819 0.479028929801635 no 1771 0.484043327210386 2573 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2147 5545932 89.7195 µM -0.0417186238085515 0.478276522905008 no 1772 0.483361503616559 2483 797404
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.0419929870682011 0.478155844812398 no 1773 0.483252144348119 2494 4330530
SGTC_1736 st036774 51 µM -0.0420197941062387 0.478144053901309 no 1774 0.483241459318458 2470 1272247
SGTC_3006 9075424 71.4286 µM -0.0429434640604356 0.477737795098751 no 1775 0.482873300689474 2492 7465181
SGTC_2223 6903751 107.57 µM -0.0430305567864318 0.477699490193266 no 1776 0.482838587806266 2526 5598863
SGTC_2336 9001819 198.65 µM -0.0434892214114124 0.477497764869828 no 1777 0.482655778233055 2513 2989602
SGTC_1259 0671-0132 43 µM -0.0437179442762593 0.477397172400504 no 1778 0.482564617713668 2511 X1259
SGTC_2705 st078069 42.8 µM -0.0442854257826137 0.477147599886196 no 1779 0.482338444409012 2527 1530061
SGTC_3292 9120825 59.784 µM -0.0442890295080556 0.477146015033446 no 1780 0.482337008139777 2478 24824900
SGTC_179 1273-0063 6.77 µM -0.0448329028504609 0.476906833610942 no 1781 0.482120249384576 2492 3108139
SGTC_550 4123-0385 25.7 µM -0.0467250604449214 0.476074777033571 no 1782 0.48136617840446 2509 5731123
SGTC_73 0327-0325 16.231 µM -0.0468720117807815 0.476010161034112 no 1783 0.481307617465844 2566 53298
SGTC_1320 1313-0481 95.3 µM -0.0471893474366013 0.475870627467682 no 1784 0.481181158789567 2489 6813365 YLR208W SEC13
SGTC_1574 spiramycin 23.7 µM -0.0476477524143208 0.475669070469764 no 1785 0.480998487149809 2476 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3253 9135987 49.47 µM -0.0481679232602368 0.47544036305769 no 1786 0.480791207015847 2503 4182430
SGTC_1142 3253-1408 9.78 µM -0.0485586970027462 0.475268553958007 no 1787 0.480635493063636 2473 256655
SGTC_1896 st058441 89 µM -0.0486326946630626 0.475236020376467 no 1788 0.480606007105015 2518 688759
SGTC_490 phenamil 164 µM -0.0496752715148727 0.474777661927059 no 1789 0.480190581298375 2515 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_3203 9113543 49.47 µM -0.0499384588248194 0.474661959520796 no 1790 0.480085714906055 2595 17018012
SGTC_1262 0737-0114 49.6 µM -0.0513644435546742 0.474035105513186 no 1791 0.479517558644037 2499 765919
SGTC_877 0771-0151 33.1 µM -0.052478621382093 0.473545364533921 no 1792 0.479073664761828 2587 6166523
SGTC_100 0086-0128 49.5915 µM -0.0525662797637592 0.473506835655376 no 1793 0.479038742329044 2494 93297
SGTC_1970 st070122 35.8 µM -0.0526270925869769 0.473480106470176 no 1794 0.479014515057163 2558 102928
SGTC_3317 9138495 8.753 µM -0.0528750852228064 0.47337110699468 no 1795 0.478915717865782 2495 17020139
SGTC_2497 7-hydroxyflavone 100 µM -0.052881649411116 0.473368221883304 no 1796 0.478913102792118 2536 5281894
SGTC_2053 5265679 138 µM -0.0531621843145258 0.473244921664026 no 1797 0.478801342765653 2498 764595
SGTC_676 falcarinol 140 µM -0.0534569165444392 0.473115384221611 no 1798 0.478683928576931 2499 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2544 sphondin 68.51 µM -0.053524538478567 0.473085664179232 no 1799 0.47865698989517 2542 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_634 1611-4317 11.2 µM -0.0536099407799579 0.473048129826354 no 1800 0.478622968153173 2492 2843522
SGTC_2213 7173844 200 µM -0.0557635080486534 0.472101715955302 no 1801 0.477765103023048 2498 892728
SGTC_2124 5246320 200 µM -0.0564348454923751 0.471806719708865 no 1802 0.477497699244149 2576 579342
SGTC_1531 st059297 52.4 µM -0.0569138633832795 0.471596241148463 no 1803 0.477306905415615 2563 7566702
SGTC_2114 5491910 81.25 µM -0.0570700074292313 0.471527633785803 no 1804 0.477244714037282 2563 2849228
SGTC_1510 1123-0200 71.5 µM -0.0580736467318928 0.471086669916811 no 1805 0.476844982908627 2546 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1214 0358-0031 63.7 µM -0.0581044847505282 0.471073121332776 no 1806 0.476832701058207 2663 4301366
SGTC_2701 st077767 14.721 µM -0.058430978501006 0.470929679413201 no 1807 0.476702669821277 2532 5721188
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.0590907824960287 0.470639812343641 no 1808 0.476439900158407 2537 551469
SGTC_1717 st033143 58.0435 µM -0.059681076884185 0.470380495622136 no 1809 0.476204821662516 2533 674616
SGTC_3147 9097027 49.47 µM -0.0604148398839504 0.470058170565713 no 1810 0.475912619864211 2549 25236841
SGTC_1436 4092-1007 8.32 µM -0.0605332661788256 0.470006150475971 no 1811 0.475865460919739 2522 2881121
SGTC_811 0416-0114 265 µM -0.0608978999701758 0.469845984176545 no 1812 0.475720260962365 2589 6612453
SGTC_2279 7948423 32.93 µM -0.0616883378646435 0.469498799151791 no 1813 0.475405513658687 2500 1247112
SGTC_1219 1469-0211 33.1 µM -0.0632337768040031 0.468820061307635 no 1814 0.474790174294099 2513 6822282
SGTC_1210 3013-0140 750 nM -0.0636488818922263 0.46863776759546 no 1815 0.474624904249283 2574 905973
SGTC_2093 5331342 194.4 µM -0.0637190576716015 0.468606950497789 no 1816 0.474596964877448 2530 33839
SGTC_1414 3917-0015 5.4 µM -0.063742801993585 0.468596523422976 no 1817 0.474587511481102 2531 6618702
SGTC_109 0132-0036 33.701 µM -0.0642349660475563 0.468380399501415 no 1818 0.47439156799684 2505 67274 A color developer.
SGTC_68 0986-0284 82.829 µM -0.0658950347438699 0.467651482897203 no 1819 0.473730696846705 2753 423278 YIL048W NEO1
SGTC_3157 9099274 49.47 µM -0.0666525896226704 0.467318885367006 no 1820 0.473429139164313 2535 17217662
SGTC_16 erodoxin 22.806 µM -0.0673340844885349 0.467019700776666 no 1821 0.473157871476447 2534 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_8 0354-0001 70 µM -0.0675952576799612 0.466905047477225 no 1822 0.473053915294909 2530 4993152
SGTC_2850 9015429 58.44 µM -0.0682368103162605 0.466623421800352 no 1823 0.472798562425936 2573 6457570
SGTC_489 paxilline 115 µM -0.0683207657064593 0.466586568702176 no 1824 0.472765147053096 2574 105008 A toxic potassium channel blocker.
SGTC_2079 5212404 121 µM -0.069111827987625 0.466239337735157 no 1825 0.472450303084587 2527 758462
SGTC_737 1950-0117 57.9 µM -0.0691835072399311 0.46620787592058 no 1826 0.472421775482747 2518 5393513
SGTC_2869 9037858 32.47 µM -0.0703297337296258 0.465704797299862 no 1827 0.471965608500326 2519 27187042
SGTC_934 2950-0684 338 µM -0.0704129657397833 0.465668268908558 no 1828 0.471932485847809 2607 1121253
SGTC_2610 ononetin 44.17 µM -0.0705892762066461 0.465590891729199 no 1829 0.471862322734694 2577 259632
SGTC_2897 9048598 12.99 µM -0.0706418167572348 0.4655678335674 no 1830 0.471841414283249 2552 6467404
SGTC_511 blebbistatin 171 µM -0.0717152366742387 0.465096773509806 no 1831 0.471414265136381 2661 3476986 A myosin inhibitor.
SGTC_1311 1190-0148 100 µM -0.0723462863857791 0.464819866168635 no 1832 0.471163164983106 2605 1961333
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0727112266625734 0.464659736564073 no 1833 0.471017957307109 2556 115019
SGTC_2127 5253358 187.912 µM -0.0727463015794457 0.46464434658644 no 1834 0.471004001398341 2532 20612
SGTC_851 0394-0702 453 µM -0.0731796743433657 0.464454198058163 no 1835 0.470831570269352 2534 762646
SGTC_3303 9125618 40.5795 µM -0.0733759226467481 0.464368093962502 no 1836 0.470753488440958 2604 22695467
SGTC_636 0kpi-0074 126 µM -0.0734193371614639 0.464349046035689 no 1837 0.470736215145629 2593 616434
SGTC_3055 9094636 49.47 µM -0.0765640111238811 0.462969554260663 no 1838 0.469485194921521 2613 25236176
SGTC_1633 st005664 67.9 µM -0.0770460563467839 0.462758131717523 no 1839 0.469293453081572 2539 2063822
SGTC_1282 0886-0010 32.4 µM -0.0780349362185742 0.46232444710917 no 1840 0.468900131314763 2563 2836211 YNL267W PIK1
SGTC_761 k216-0224 480 µM -0.0780790836723671 0.462305086777534 no 1841 0.468882572602149 2547 1340404
SGTC_334 1502-1024 68.5 µM -0.0784321928778033 0.462150238226054 no 1842 0.468742133092171 2643 3296216
SGTC_2841 9004761 38.96 µM -0.0788227614290082 0.461978969355807 no 1843 0.468586799684887 2558 2991039
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0789390213724883 0.461927989373225 no 1844 0.468540562749551 2658 165506
SGTC_1815 st051655 58.2 µM -0.0789784029389548 0.461910720699005 no 1845 0.468524900676222 2544 5984156
SGTC_1447 4239-0816 81.9 µM -0.079269224711321 0.461783198630566 no 1846 0.468409242187305 2554 1341554
SGTC_2880 9042983 58.44 µM -0.0797986933215097 0.461551042710834 no 1847 0.468198681795024 2653 6464714
SGTC_1917 st066507 28.5 µM -0.0810462291318995 0.461004088052618 no 1848 0.467702593934511 2529 3156428
SGTC_2724 maprotiline 69.64 µM -0.0851291858006897 0.459214526609529 no 1849 0.466079343803511 2549 4011 A tricyclic antidepressant.
SGTC_743 1275-0778 158 µM -0.086774029973058 0.458493822192123 no 1850 0.465425565410048 2634 2849257 YMR203W TOM40
SGTC_1944 st076371 56.9 µM -0.0881085545814336 0.457909187430919 no 1851 0.464895198626206 2564 24208455
SGTC_89 0302-0250 142.109 µM -0.0881444309871637 0.457893471779073 no 1852 0.464880941481202 2544 4203518 YLR208W SEC13
SGTC_403 arphamenine a 50 µM -0.0883369445891614 0.457809142361952 no 1853 0.464804438090196 2575 5487158 An arginine aminopeptidase inhibitor.
SGTC_3172 9105863 49.47 µM -0.0883837475020031 0.457788640916371 no 1854 0.4647858391773 2554 2348785
SGTC_144 4161-2749 112.381 µM -0.0895084734210551 0.457296002339079 no 1855 0.464338909899597 2551 797501 YMR168C CEP3
SGTC_1540 guanosine 70.6 µM -0.0905575317063254 0.456836565888863 no 1856 0.463922089005036 2549 6802 Guanosine is a purine nucleoside
SGTC_2160 5660466 132.927 µM -0.0923147026076761 0.456067140139402 no 1857 0.463224003629534 2545 2859134
SGTC_324 1315-0088 19.6 µM -0.0924988214586046 0.455986528106106 no 1858 0.463150863773921 2549 6787421
SGTC_3197 9113331 49.47 µM -0.0937095727448361 0.455456474907524 no 1859 0.462669932896347 2675 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_108 0509-0257 621.132 µM -0.094280852578784 0.455206402538846 no 1860 0.462443029792764 2613 536624
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.094326595687323 0.455186379689923 no 1861 0.462424861897901 2552 6708784 An antioxidant flavonoid
SGTC_1023 4482-3888 16 µM -0.0961235205133327 0.454399913446573 no 1862 0.461711235566129 2671 3303168
SGTC_283 0987-0079 11.7 µM -0.0970273592527486 0.454004394618967 no 1863 0.461352333704867 2592 411556
SGTC_1046 2001-0062 216 µM -0.0975503779939065 0.453775543006344 no 1864 0.46114466455433 2578 739778
SGTC_990 3985-0011 41.3 µM -0.0976556680256509 0.453729474247591 no 1865 0.461102859508718 2643 5399565 YGL099W LSG1
SGTC_670 4204-0025 119 µM -0.100205031176785 0.452614213549701 no 1866 0.460090775909949 2694 719039
SGTC_1203 3992-3522 103 µM -0.100352099489219 0.452549887423596 no 1867 0.46003239839721 2773 5322312
SGTC_659 k018-0002 107 µM -0.100865979424387 0.452325131558127 no 1868 0.45982842491107 2615 6797879 YHR007C ERG11
SGTC_1843 st055809 45.5 µM -0.10168615063922 0.451966444634359 no 1869 0.459502897674118 2700 16413835
SGTC_3114 9122766 49.47 µM -0.102679254391428 0.451532181320312 no 1870 0.45910876960068 2646 17176985
SGTC_3080 9117754 49.47 µM -0.102680725895688 0.451531537905452 no 1871 0.459108185641934 2623 9550191
SGTC_1134 3477-0009 42.5 µM -0.103359038221647 0.45123495959959 no 1872 0.458839010369071 2775 3973534
SGTC_1198 1612-1005 86.7 µM -0.10438941736647 0.450784499349545 no 1873 0.458430160258645 2746 6998509
SGTC_124 0136-0217 7.121 µM -0.104774637534834 0.45061610538118 no 1874 0.458277317786502 2608 3976905
SGTC_2960 9079389 5.97 µM -0.104942836744445 0.45054258207836 no 1875 0.458210583902051 2647 16457355
SGTC_1782 st039423 80.636 µM -0.10497442140874 0.450528775967021 no 1876 0.458198052658555 2633 2068169
SGTC_568 1193-0097 7.48 µM -0.105154064103645 0.450450252698576 no 1877 0.458126780051008 2609 3646150
SGTC_603 3794-0023 45.9 µM -0.1069559558447 0.449662739110292 no 1878 0.457411960696511 2604 3802260
SGTC_3239 9133757 49.47 µM -0.107137506259 0.449583403763907 no 1879 0.457339946350883 2589 17036923
SGTC_1966 st070145 16.1 µM -0.107588260789959 0.449386438177637 no 1880 0.457161154733655 2579 3748532
SGTC_695 3505-6186 243 µM -0.107691832846712 0.449341182198878 no 1881 0.457120074139534 2695 1819379
SGTC_1180 1193-0155 285 µM -0.108888312547958 0.448818426372215 no 1882 0.456645538378933 2689 2921347
SGTC_1733 st037357 54.9 µM -0.109057037261022 0.448744715719321 no 1883 0.456578625436106 2595 1272339 YGL099W LSG1
SGTC_2184 6075246 200 µM -0.110179123152239 0.448254555931126 no 1884 0.456133659385604 2644 2267320
SGTC_2848 9016370 25.97 µM -0.110754054504218 0.448003439733916 no 1885 0.455905690155223 2600 7894410
SGTC_287 k060-0039 29.6 µM -0.111451433944153 0.447698869129063 no 1886 0.455629187841263 2688 5861974
SGTC_2276 7947513 42.08 µM -0.112110054486286 0.447411254232364 no 1887 0.455368072679813 2688 2105100
SGTC_2066 5222451 176 µM -0.113345760172306 0.446871705091423 no 1888 0.454878219797919 2599 2281147
SGTC_3299 9121982 43.1275 µM -0.113718523619965 0.446708963750697 no 1889 0.454730464026536 2639 17594604 YPL160W CDC60
SGTC_2489 cantharidin 73.42 µM -0.114448014081791 0.446390508258256 no 1890 0.454441327137132 2622 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1080 nisoldipine 24.4 µM -0.115087213394452 0.446111497336979 no 1891 0.454187997395548 2598 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1271 0832-2808 169 µM -0.115126772114925 0.446094230804705 no 1892 0.454172319954249 2704 3663794
SGTC_417 st075190 100 µM -0.115616157315183 0.445880633135092 no 1893 0.453978378548838 2634 222757
SGTC_955 1216-0110 33 µM -0.115955920350762 0.445732348973784 no 1894 0.45384373826216 2589 3619719
SGTC_2656 pseudo-anisatin 100 µM -0.116982162457278 0.445284508136662 no 1895 0.453437094358102 2605 6708809 A neurotoxin.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.117216928282859 0.445182068688615 no 1896 0.453344076281792 2607 3256 An antibiotic and ribosome inhibitor.
SGTC_1470 k295-0292 231 µM -0.117324081934155 0.445135313692038 no 1897 0.453301621095541 2713 5045612
SGTC_3068 9116768 49.47 µM -0.117759610145857 0.444945284912042 no 1898 0.453129066619381 2691 41904888
SGTC_1177 0983-0204 23.6 µM -0.117770369784722 0.444940590448339 no 1899 0.453124803806847 2691 766818
SGTC_1081 sertraline 6 µM -0.117839712076016 0.444910336377533 no 1900 0.453097331528481 2684 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2149 5554786 194.827 µM -0.117886017079381 0.444890133663804 no 1901 0.453078986370699 2623 745063 YPR165W RHO1
SGTC_1909 st060837 51.5 µM -0.118963646086459 0.444420008372937 no 1902 0.452652078708666 2665 678937
SGTC_134 0269-0018 6.916 µM -0.119441899632094 0.444211390996261 no 1903 0.452462633882197 2705 4378915
SGTC_235 0330-0087 5 mM -0.120105544002723 0.4439219305252 no 1904 0.45219977035327 2625 46494818 YHR062C RPP1
SGTC_1366 1683-0113 21.9 µM -0.120336639901284 0.443821140891838 no 1905 0.452108240271681 2620 708623
SGTC_762 1165-0429 115 µM -0.121189146845216 0.443449361951901 no 1906 0.451770610159617 2681 5967793
SGTC_1209 2323-2347 50.3 µM -0.122154556038859 0.443028406366115 no 1907 0.451388307936749 2607 5412760
SGTC_2723 salbutamol 83.58 µM -0.123600576475302 0.442398006193118 no 1908 0.450815768013146 2707 9884233 β2-adrenoceptor agonist
SGTC_2994 9053520 71.4286 µM -0.123815191774659 0.442304455920165 no 1909 0.450730801538336 2722 4647384
SGTC_1018 4259-0013 28.1 µM -0.124241516482931 0.442118631592988 no 1910 0.4505620257353 2777 6801262
SGTC_261 5-fluorouridine 15.376 µM -0.124441639913625 0.442031407161471 no 1911 0.4504828028367 2711 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2398 5228213 48.84 µM -0.125306877759252 0.441654322901554 no 1912 0.450140303719217 2674 80771 YMR134W ERG29
SGTC_1464 k208-0027 110 µM -0.127398440829065 0.440743005870084 no 1913 0.449312525112117 2697 X1464
SGTC_2543 pimpinellin 60.67 µM -0.127696487593437 0.440613169044203 no 1914 0.449194584915583 2617 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_264 promethazine 12.5 mM -0.128351630015937 0.44032779463689 no 1915 0.448935354054472 2623 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_535 2293-4129 48.2 µM -0.128621927904166 0.440210064223326 no 1916 0.448828407236974 2708 396118 YIL048W NEO1
SGTC_29 0299-0004 12.984 µM -0.129442616330092 0.439852639227463 no 1917 0.448503714176285 2628 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1982 st072467 71.9 µM -0.129540248043893 0.439810122066256 no 1918 0.448465089945193 2609 3163533
SGTC_795 0685-0265 78 µM -0.129585960571858 0.439790215177877 no 1919 0.448447005710217 2634 302754
SGTC_3255 9139072 49.47 µM -0.130194180342362 0.439525362182723 no 1920 0.448206399402998 2707 17646060
SGTC_2753 fluvastatin 17.09 µM -0.130394163663053 0.439438284137418 no 1921 0.448127291945789 2706 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1087 pterostilbene 9.05 µM -0.130402166898623 0.4394347993772 no 1922 0.448124126146599 2741 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2451 5856223 45.7 µM -0.131383393435616 0.439007590417365 no 1923 0.447736012451664 2678 2179896
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.131617375263103 0.438905729272155 no 1924 0.447643470808365 2717 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_814 3342-0569 96 µM -0.131895942157622 0.438784463836207 no 1925 0.447533299138837 2635 4346283
SGTC_1325 1431-0015 227 µM -0.132853180729222 0.438367803654182 no 1926 0.447154747471706 2642 1103340
SGTC_787 4152-0075 138 µM -0.133021892339464 0.438294375098975 no 1927 0.447088033388021 2682 9566539
SGTC_1624 st003710 6.25 µM -0.133167103825959 0.43823117623155 no 1928 0.447030613220017 2770 24207033
SGTC_2716 st080858 38.6235 µM -0.133925979086092 0.437900924600023 no 1929 0.446730553500441 2707 5296050
SGTC_1437 4092-1038 11.6 µM -0.135482385791919 0.437223734275321 no 1930 0.446115244975268 2662 3977136
SGTC_1907 st060210 83.7 µM -0.135590841982994 0.43717655197235 no 1931 0.446072372813648 2793 688793
SGTC_594 1487-1584 10.8 µM -0.136014874628025 0.436992091262487 no 1932 0.445904760996007 2683 5013332
SGTC_137 0438-0332 85.389 µM -0.136054396333397 0.436974899411162 no 1933 0.445889139330274 2620 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_749 1000-0129 128 µM -0.13805757237816 0.436103679009754 no 1934 0.445097458472171 2793 708470
SGTC_3037 9091026 49.47 µM -0.139928073385215 0.435290441298948 no 1935 0.444358410071517 2711 25236398 YIL048W NEO1
SGTC_3345 9148410 3.559 µM -0.139929765954406 0.435289705544042 no 1936 0.444357741412459 2724 4903596
SGTC_2238 6671620 73.2395 µM -0.14086969086797 0.434881157594135 no 1937 0.443986443261327 2602 729941
SGTC_2594 a-mangostin 100 µM -0.141275097772751 0.43470496478089 no 1938 0.443826310694354 2789 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1981 st071826 47 µM -0.141360103632996 0.434668022254088 no 1939 0.443792735204487 2749 11838600
SGTC_3138 9097216 49.47 µM -0.141424981079586 0.434639827678103 no 1940 0.443767110277345 2598 25237486
SGTC_2001 4023502 57.655 µM -0.142870067611734 0.434011905378098 no 1941 0.443196399304245 2760 108941 YCR052W RSC6
SGTC_3190 9110366 49.47 µM -0.144016719383939 0.433513778006197 no 1942 0.442743633555033 2706 17123768
SGTC_2218 6965428 192.983 µM -0.144453596023412 0.433324018208275 no 1943 0.442571148527748 2664 675684
SGTC_3035 9091303 49.47 µM -0.1459253502857 0.43268486691664 no 1944 0.441990159581744 2662 25237002
SGTC_606 k015-0008 38.6 µM -0.147898175543409 0.431828387736228 no 1945 0.441211564039051 2781 1970475
SGTC_1398 3558-0053 112 µM -0.148241714907893 0.431679276745246 no 1946 0.44107600587395 2673 4532369
SGTC_2496 diffractaic acid 79.83 µM -0.14927681503545 0.431230057309205 no 1947 0.440667604599735 2908 94870 An apoptosis inducer which activates caspases.
SGTC_2795 7780010 54.55 µM -0.150060452917224 0.430890028205639 no 1948 0.440358460311557 2790 953673
SGTC_2210 7115885 190.385 µM -0.150322409572058 0.430776373740446 no 1949 0.440255126795046 2674 2927039
SGTC_2299 7976368 114.88 µM -0.150784451358609 0.430575922829464 no 1950 0.44007287601983 2784 2979718
SGTC_1195 1502-0147 41.1 µM -0.152344117015931 0.429899414249223 no 1951 0.439457765316705 2666 817940
SGTC_2902 5787006 60.46 µM -0.153461565164392 0.429414844937637 no 1952 0.439017148896104 2699 591003
SGTC_35 0133-0054 64.071 µM -0.153552835985766 0.429375271019972 no 1953 0.438981163601132 2701 99677
SGTC_2894 9048625 32.47 µM -0.155252334789163 0.428638519085744 no 1954 0.438311195611097 2790 4092861
SGTC_468 gf-109203x 121 µM -0.155817493941097 0.428393571164676 no 1955 0.438088440441236 2765 2396 A protein kinase C inhibitor.
SGTC_1731 st035964 63 µM -0.15630466134248 0.428182448097898 no 1956 0.437896441140274 2741 6739575
SGTC_59 0330-0160 1.33 µM -0.156760505397929 0.427984918200489 no 1957 0.437716800035007 2699 4293482
SGTC_1112 tnp00069 1.16933 µM -0.157869544524683 0.427504416180403 no 1958 0.437279798513798 2800 145826
SGTC_3279 9140807 49.47 µM -0.15957167888853 0.426767159229163 no 1959 0.436609245018635 2671 45595718
SGTC_202 3594-0513 34.79 µM -0.160404098689656 0.426406700587461 no 1960 0.436281380569344 2669 708429
SGTC_561 1550-0330 72.9 µM -0.160625346989872 0.426310904854057 no 1961 0.436194245051952 2707 6812934
SGTC_1884 5633444 25 µM -0.162206534569924 0.425626411686058 no 1962 0.435571607052898 2840 5724239
SGTC_2104 5389443 200 µM -0.162623404755928 0.425445986597604 no 1963 0.435407478986239 2851 2244536
SGTC_1705 st027868 56.3335 µM -0.163775466782503 0.424947445303306 no 1964 0.434953952774174 2777 292948
SGTC_1434 4073-0095 163 µM -0.164159263563706 0.424781388369928 no 1965 0.434802884480691 2709 24133745
SGTC_2940 9060638 45.86 µM -0.164678843591609 0.424556603519047 no 1966 0.434598384988997 2798 4027022
SGTC_3167 9103034 49.47 µM -0.167384930338498 0.423386272960663 no 1967 0.433533590872304 2680 5127859
SGTC_820 1582-0060 59.9 µM -0.167500569738736 0.423336276119954 no 1968 0.433488099637776 2732 3848840
SGTC_3020 9089140 49.47 µM -0.167904681627704 0.423161567533965 no 1969 0.433329133506711 2770 17217859
SGTC_1659 st012954 42.1 µM -0.168047639619315 0.423099766513054 no 1970 0.433272900477489 2835 24207262
SGTC_2652 actinonin 100 µM -0.168233681729109 0.423019342976909 no 1971 0.43319972218185 2675 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1113 artemisinin 1.17947 µM -0.169987560589875 0.422261322532804 no 1972 0.432509959742725 2755 2240 An anti-malaria and mitochondrial poison.
SGTC_2176 5809774 33.9695 µM -0.170579295315793 0.422005641609887 no 1973 0.432277289620476 2841 2870539
SGTC_3284 9108171 64.8615 µM -0.172225770892486 0.42129439409796 no 1974 0.43163001917185 2813 8687505
SGTC_456 gingerol 170 µM -0.173335677869874 0.420815079192225 no 1975 0.43119379061704 2880 442793 A herb.
SGTC_1289 0976-0073 69.1 µM -0.173403735358124 0.420785692280845 no 1976 0.431167044596365 2830 3391136
SGTC_440 fluspirilene 35.1 µM -0.174014890252961 0.42052181819812 no 1977 0.430926880019219 2958 3396 An atypical antipsychotic.
SGTC_449 xestospongin c 11.1929 µM -0.174285089180175 0.420405167670814 no 1978 0.430820708508777 2838 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1671 st016596 74.5 µM -0.174814248798226 0.420176738656662 no 1979 0.430612795911955 2747 2829167
SGTC_527 4476-4215 268 µM -0.175378143902134 0.419933344528069 no 1980 0.430391256531579 2739 4418754
SGTC_1587 estradiol valerate 56.1 µM -0.175533793125132 0.419866167019146 no 1981 0.430330109949149 2797 13791 A steroid.
SGTC_2917 7979103 53.79 µM -0.175731362064278 0.419780900511143 no 1982 0.430252497670362 2873 2980565
SGTC_1767 st044992 70.3 µM -0.177300713182197 0.419103736376167 no 1983 0.429636095315476 2765 9600693
SGTC_1139 k015-0024 46.9 µM -0.178410008939168 0.418625227337414 no 1984 0.429200494705141 2710 2766652
SGTC_77 0828-0286 12.516 µM -0.179121420126051 0.418318414254423 no 1985 0.428921181586771 2678 745345
SGTC_901 1112-0062 60.1 µM -0.179538060915607 0.418138751014026 no 1986 0.428757617265293 2732 1908457
SGTC_3355 9151058 44.0485 µM -0.179746433308948 0.418048903375995 no 1987 0.428675819278816 2703 17015728
SGTC_1175 0741-0056 27.6 µM -0.181468678292834 0.417306456491884 no 1988 0.427999858033784 2904 765927
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.182362140190644 0.416921407721932 no 1989 0.427649267659716 2872 61125 An anti-inflammatory.
SGTC_599 1935-0052 86.5 µM -0.183284374196913 0.41652404281874 no 1990 0.427287447151535 2728 9557311
SGTC_1224 0823-0416 294 µM -0.184671589973858 0.415926490996625 no 1991 0.426743315393623 2859 3598164
SGTC_2845 9003024 42.97 µM -0.185064104754298 0.415757448024354 no 1992 0.426589377752323 2969 2990173
SGTC_3161 9100388 49.47 µM -0.186550336600671 0.415117519236275 no 1993 0.426006604341655 2754 25236368
SGTC_1092 toremifene 6.32 µM -0.186941707613853 0.414949043485838 no 1994 0.425853168821422 2717 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2290 7904846 200 µM -0.188251713324305 0.414385231691082 no 1995 0.4253396678556 2825 2962154
SGTC_3083 9117465 49.47 µM -0.191155013750746 0.413136313847288 no 1996 0.424202073733519 2853 16420915
SGTC_629 3448-6466 76.7 µM -0.195940528758617 0.411079643511412 no 1997 0.422328357354334 2780 573744
SGTC_1749 st037932 54.2 µM -0.196826742214086 0.410699041916589 no 1998 0.421981561596967 2886 594497
SGTC_2680 butyl paraben 22.24 µM -0.197092527803287 0.410584911500233 no 1999 0.421877565346721 2741 7184 An antifungal and steroid mimetic.
SGTC_160 3453-0671 289.699 µM -0.198227178172638 0.410097768996396 no 2000 0.421433662136202 2793 5322268
SGTC_319 1348-1596 45.5 µM -0.198828566635282 0.409839629459253 no 2001 0.421198424580128 2961 5380505
SGTC_2583 asiatic acid 100 µM -0.199115062154877 0.409716668069117 no 2002 0.421086369619629 2911 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3210 9128157 49.47 µM -0.200605377494598 0.409077181150994 no 2003 0.420503576459424 2901 17590849
SGTC_1716 st033144 30.6155 µM -0.201108357514743 0.408861409436535 no 2004 0.420306923575508 2893 674617
SGTC_656 4090-1979 187 µM -0.201126110883309 0.408853793982635 no 2005 0.420299982805836 2863 22330961
SGTC_850 0388-0143 75.9 µM -0.202237839296173 0.408376977565233 no 2006 0.419865396386014 2775 67273
SGTC_2495 cafestol 54.53 µM -0.2032996459727 0.40792169900962 no 2007 0.419450416111289 2976 16667697 An anti-infammatory.
SGTC_2132 5317594 122.667 µM -0.204012368045845 0.407616169674842 no 2008 0.419171916933495 2762 794577
SGTC_423 5-fluorouracil 457 µM -0.206303962422014 0.406634191785692 no 2009 0.418276741772943 2719 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3286 9117135 37.221 µM -0.207553795812213 0.406098868874154 no 2010 0.417788692115583 2808 3438150
SGTC_613 3914-0030 117 µM -0.208645717071961 0.405631325766943 no 2011 0.417362409427944 2726 1145395
SGTC_2263 7948595 193.29 µM -0.208683830610773 0.405615008590366 no 2012 0.417347531771184 2771 2971371
SGTC_1 0258-0098 57.368 µM -0.210017374605368 0.405044194898159 no 2013 0.416827056231307 2835 6790032 YDR047W HEM12
SGTC_298 1391-0729 10 µM -0.211984806747617 0.404202419142141 no 2014 0.416059443712573 2791 3237558
SGTC_924 2046-0044 21.3 µM -0.212328354389404 0.404055475910144 no 2015 0.415925438050684 2763 3623589
SGTC_3059 1327-0034 3 µM -0.213089237492184 0.403730076918268 no 2016 0.415628679554494 2805 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_765 1319-0117 244 µM -0.213528717008247 0.403542159605246 no 2017 0.415457296316297 2775 3487746 YGL099W LSG1
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.213585781416029 0.403517761032888 no 2018 0.415435044164625 2866 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1867 st057372 64 µM -0.214461588999297 0.403143346150935 no 2019 0.415093558814189 2785 688837
SGTC_329 k048-0121 21.3 µM -0.215082057416171 0.402878144551535 no 2020 0.414851671327419 2866 6832902
SGTC_1753 st043925 64 µM -0.215442875291999 0.402723943736396 no 2021 0.414711022551924 2887 670181
SGTC_900 1112-0045 141 µM -0.216007784237396 0.402482552004972 no 2022 0.414490839929324 2811 56211 YIL048W NEO1
SGTC_2131 toluylene red 5.2905 µM -0.216260972043944 0.402374374163738 no 2023 0.414392164501102 2825 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_214 4373-3496 70 µM -0.217160192943186 0.401990230613995 no 2024 0.4140417529173 2828 3779166
SGTC_3084 9116877 49.47 µM -0.217328256007827 0.401918445237095 no 2025 0.413976269087893 2768 27241325
SGTC_2502 avocadyne acetate 18.59 µM -0.217459529657194 0.401862376155968 no 2026 0.413925121492281 2731 3952079
SGTC_414 piperonyl butoxide 100 µM -0.21837376065977 0.401471949507978 no 2027 0.413568954080163 2786 5794 A potent inhibitor of cytochrome P450.
SGTC_2049 5262831 67.185 µM -0.218897859291821 0.401248175044593 no 2028 0.413364807035183 2860 763417
SGTC_1830 st055982 50.3 µM -0.218965501362699 0.401219296258778 no 2029 0.413338460782123 2788 455313 An antimicrobial agent.
SGTC_2185 6113692 200 µM -0.219477019399172 0.401000928648674 no 2030 0.413139239670295 2911 874150
SGTC_2981 9013952 38.96 µM -0.219893157285547 0.400823301739249 no 2031 0.412977182795292 2850 2996344
SGTC_2057 5236571 38.335 µM -0.220769659533692 0.400449237127401 no 2032 0.412635894438567 2940 54684039 YBR257W POP4
SGTC_3316 9136639 10.545 µM -0.22196587624892 0.399938875434675 no 2033 0.412170223760959 2892 4903665
SGTC_310 1273-0058 1.06 µM -0.22254264327851 0.399692860791927 no 2034 0.411945740442513 2897 2734232
SGTC_1661 st013063 9.66 µM -0.222846062235495 0.399563456217762 no 2035 0.411827658404233 2812 721395
SGTC_764 1951-2361 146 µM -0.223183047976955 0.399419748740539 no 2036 0.411696522485139 2816 5438930
SGTC_1022 4477-0945 21.3 µM -0.223230130898966 0.399399671325868 no 2037 0.411678201241866 2816 4648966
SGTC_3011 9081274 71.4286 µM -0.223530405880126 0.399271632320394 no 2038 0.411561360625855 2822 6625322
SGTC_1168 k815-0004 80.5 µM -0.223662655209305 0.399215243870173 no 2039 0.411509903304104 2793 642433
SGTC_2165 5727197 32.143 µM -0.223741199522915 0.399181755152108 no 2040 0.411479342961946 3213 1361712
SGTC_776 4476-4378 112 µM -0.224144186800667 0.399009946274228 no 2041 0.411322555477202 2904 2892008
SGTC_55 0767-0285 6.563 µM -0.224160060772979 0.399003178993434 no 2042 0.411316379789865 2927 3116166
SGTC_1591 genipin 88.4 µM -0.225033084465954 0.39863104444056 no 2043 0.410976768288377 2948 442424 A DNA cross-linking agent.
SGTC_1839 st053978 48 µM -0.225051668042523 0.39862312401685 no 2044 0.410969539888881 2847 3788398
SGTC_314 1671-0008 2.74 µM -0.226195495659409 0.39813569882215 no 2045 0.410524686888773 2797 3913060
SGTC_1945 st075991 56.6 µM -0.226341500471841 0.39807349245576 no 2046 0.410467911534247 2854 1084980
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.226393171804829 0.398051478145348 no 2047 0.410447819096329 3004 688798
SGTC_3045 9092950 49.47 µM -0.228713953191067 0.397063056606691 no 2048 0.409545624573128 2889 44120432
SGTC_3189 9110682 49.47 µM -0.228829006604204 0.397014072461697 no 2049 0.409500910434417 2914 17122418
SGTC_607 4491-0986 66.8 µM -0.229525827331464 0.396717434846273 no 2050 0.409230124533572 2943 698981 YDR232W HEM1
SGTC_2801 7907800 81.82 µM -0.231151095673312 0.396025788226653 no 2051 0.408598710580993 2905 6620925
SGTC_3046 9092212 49.47 µM -0.231344297773097 0.395943591164286 no 2052 0.408523667639204 2790 25236637
SGTC_2877 9040724 71.43 µM -0.234122267929205 0.394762228094125 no 2053 0.407445029488875 3023 6463895
SGTC_99 0109-0120 622.8 µM -0.234129009100639 0.394759362506914 no 2054 0.407442412857456 2919 759414
SGTC_2040 5100729 123 µM -0.234366069676519 0.394658594658745 no 2055 0.407350398813911 2824 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_755 1995-0008 37.3 µM -0.234455719575782 0.394620488819712 no 2056 0.407315602922771 2851 689533
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.235005950741583 0.394386634243359 no 2057 0.40710205726495 2834 4174840
SGTC_2249 haloperidol 116.36 µM -0.235396131858278 0.394220825838941 no 2058 0.40695064403383 2796 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_83 0170-0301 39.027 µM -0.235457888508247 0.394194583958172 no 2059 0.40692668009409 2812 3089716
SGTC_1768 st044301 37.178 µM -0.23686116560005 0.393598427556946 no 2060 0.406382249052857 2875 3931349
SGTC_2513 baicalein 25.65 µM -0.239994640140557 0.392268130535868 no 2061 0.405167205874115 2875 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_374 0880-0231 82.3 µM -0.240023763191112 0.392255772403711 no 2062 0.405155917320768 2912 6833587
SGTC_1930 st074634 34.3 µM -0.241443828147076 0.391653311328632 no 2063 0.404605573671127 2808 684253 YOR116C RPO31
SGTC_2676 harmalol 100 µM -0.243143776936449 0.390932451519725 no 2064 0.403947009731236 2911 5459187 A monoamine oxidase inhibitor
SGTC_580 1123-0028 41 µM -0.243285327237849 0.39087244426427 no 2065 0.403892185079189 2825 1677248 YPR107C YTH1
SGTC_22 0964-0034 14.468 µM -0.243594445082568 0.39074140932885 no 2066 0.403772465453952 2859 138402
SGTC_114 0364-0001 490.298 µM -0.243617636316527 0.390731579073795 no 2067 0.403763483981169 2899 4003655
SGTC_2979 9012552 45.46 µM -0.243675839311017 0.390706908409481 no 2068 0.403740943419989 2941 17100905
SGTC_1937 st074714 47.2 µM -0.244064920427954 0.390541998824867 no 2069 0.403590270268893 2800 17250970
SGTC_1797 st048695 56.8 µM -0.244436648341076 0.390384462676527 no 2070 0.403446330576524 2970 592262 YIL048W NEO1
SGTC_696 1560-0013 611 µM -0.245248230818446 0.390040581264474 no 2071 0.403132116807175 3048 1650269
SGTC_2366 9070441 60.58 µM -0.245391120096999 0.389980045526747 no 2072 0.40307680199915 2855 6837235
SGTC_1194 1488-0194 225 µM -0.246024073620233 0.389711923795495 no 2073 0.402831798538396 2825 1391452
SGTC_2083 5306046 65.942 µM -0.246475314321447 0.38952080840172 no 2074 0.402657155710358 2864 539837
SGTC_576 1073-0113 22.7 µM -0.247315651458152 0.389164969004031 no 2075 0.402331973421473 2885 5439563
SGTC_2953 9074162 66.49 µM -0.247692107145074 0.389005589578064 no 2076 0.402186319600207 2959 16451992
SGTC_1814 st052110 31.539 µM -0.248352136008348 0.388726199333152 no 2077 0.40193098176056 2971 674163
SGTC_1485 3909-9022 254 µM -0.24872330213637 0.388569109966049 no 2078 0.401787411331547 2849 714516
SGTC_1158 4092-0494 91.8 µM -0.248904996150132 0.388492217894637 no 2079 0.401717135267755 2973 1148199
SGTC_2069 5228469 200 µM -0.249844879643622 0.388094533345042 no 2080 0.401353655575946 2970 2835210
SGTC_2974 9094440 9.66 µM -0.25006537410218 0.388001254458851 no 2081 0.401268396442682 3038 25236134
SGTC_3143 9086658 49.47 µM -0.251784790957957 0.387274087301441 no 2082 0.400603706867235 2906 25236626
SGTC_3028 9087778 49.47 µM -0.253206017071126 0.386673327806182 no 2083 0.40005450852165 2848 17217395
SGTC_1600 coumarin 106 71.1 µM -0.253433791265843 0.386577071700839 no 2084 0.399966509056025 3009 100336 A hepatotoxic, DNA x-linker.
SGTC_1240 0356-0016 42.1 µM -0.254148829930022 0.386274945708218 no 2085 0.399690290326758 2900 4305613
SGTC_1713 st033146 12.748 µM -0.25631154168735 0.385361553278588 no 2086 0.398855142942637 3000 674619
SGTC_1329 1447-1697 50.6 µM -0.258713804340058 0.384347734853697 no 2087 0.397928033890889 2971 2840515
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.258805664953438 0.384308982894575 no 2088 0.397892593380662 2918 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1301 naphtanilide LB 4.81 µM -0.259221147581981 0.384133723465517 no 2089 0.397732307609378 2992 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3087 9117406 49.47 µM -0.263176254311639 0.382466565973159 no 2090 0.396207366083479 2997 42546093
SGTC_2944 9067346 25.62 µM -0.263351844227875 0.382392601495198 no 2091 0.396139701781698 3037 6473075
SGTC_2539 epi(13)torulosol 80 µM -0.263585212094287 0.382294305609619 no 2092 0.396049777350313 2979 6708597
SGTC_1796 st049173 110.4 µM -0.266547144010301 0.38104738393049 no 2093 0.394908928241638 2963 94134
SGTC_2617 dihydrotanshinone i 20.83 µM -0.267946997520306 0.380458498677577 no 2094 0.3943700585582 2878 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1368 1852-0141 284 µM -0.268650632292014 0.380162600667659 no 2095 0.394099272582319 2987 2838987
SGTC_731 3966-0296 387 µM -0.270799353521135 0.379259438282943 no 2096 0.393272678560716 2886 660956
SGTC_1481 3346-2004 36 µM -0.270894098884724 0.379219629512739 no 2097 0.393236241901048 2912 2770522
SGTC_2674 ligustilide 100 µM -0.271558485707017 0.378940512832335 no 2098 0.392980761897524 2969 5319022 A signalling regulator.
SGTC_169 k015-0017 16.025 µM -0.271595283241969 0.378925055600545 no 2099 0.392966613302571 3102 1840002
SGTC_545 4218-0007 221 µM -0.27184212664154 0.378821371171762 no 2100 0.392871706055992 3009 2840508
SGTC_1991 st073000 8.92 µM -0.272050719956559 0.378733760156859 no 2101 0.392791510305129 3080 4301969 YIL048W NEO1
SGTC_2903 5923464 63.88 µM -0.273056254240174 0.378311514465411 no 2102 0.392404986664975 2968 2876576
SGTC_2568 diosmetin 100 µM -0.2731804242151 0.378259382862783 no 2103 0.392357263541702 3062 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_27 0485-0001 32.618 µM -0.273637950651716 0.378067313800991 no 2104 0.392181433152118 2861 2054479
SGTC_1610 st001799 48.1 µM -0.275342969059323 0.37735181480035 no 2105 0.391526377606554 2854 621897
SGTC_1065 prochlorperazine maleate 2.48 µM -0.2792745648813 0.37570355570861 no 2106 0.390017062160309 2921 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_32 0928-0142 34.1 µM -0.279919672241213 0.375433320282909 no 2107 0.389769567024411 2967 2244242
SGTC_2429 5902844 64.44 µM -0.282009061228948 0.374558495497095 no 2108 0.388968281163517 3064 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_960 1222-0186 7.7 µM -0.282574849609057 0.374321711388402 no 2109 0.388751380993424 3015 3126296
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.285328204460321 0.373170102299456 no 2110 0.38769635325851 2912 66535 A nucleotide analog.
SGTC_1951 sophoraflavanone G 9.2 µM -0.285706122854939 0.373012123535345 no 2111 0.387551607368691 2907 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2692 st077426 47.7 µM -0.285953962053536 0.372908532520246 no 2112 0.387456691377135 3084 25238571
SGTC_2106 5357045 167.29 µM -0.286180258791717 0.37281395377761 no 2113 0.387370031464528 3001 668842
SGTC_2907 7721985 69.9 µM -0.286486118523416 0.3726861345619 no 2114 0.387252911971743 2972 3267881
SGTC_2270 7924575 90.91 µM -0.287434689013493 0.372289814816915 no 2115 0.386889751648073 3078 1262135
SGTC_2624 nerol 100 µM -0.287891036472754 0.372099197632587 no 2116 0.386715074222777 2892 637566 A natural product oil.
SGTC_2466 5983409 37.09 µM -0.287895408010886 0.372097371784432 no 2117 0.386713401027504 2943 2879657
SGTC_1812 st052057 4.327 µM -0.288118161821857 0.372004338628239 no 2118 0.386628145352257 2882 3645418
SGTC_2156 5649887 115 µM -0.288843244206552 0.371701559654241 no 2119 0.386350668872721 3015 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_467 ro 31-8220 72.8 µM -0.289029835083032 0.37162365610409 no 2120 0.386279273168879 2961 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_158 k038-0087 26.446 µM -0.290401577944801 0.371051101374679 no 2121 0.385754518334253 2881 X158
SGTC_518 1021-0119 62.6 µM -0.291083096815705 0.370766746747393 no 2122 0.385493883627314 2963 1097762
SGTC_666 0272-0154 136 µM -0.291752839789319 0.37048737420409 no 2123 0.385237802768109 2963 6870312
SGTC_1960 st011366 51.8 µM -0.292181188791535 0.370308731080391 no 2124 0.385074046790206 2894 3972846
SGTC_350 k064-0020 19.8 µM -0.292472479420262 0.370187264180825 no 2125 0.384962699343007 3120 2790705
SGTC_299 1273-0059 1.44 µM -0.293465656468135 0.3697732111384 no 2126 0.384583123306703 3021 2848077
SGTC_2889 9059656 51.95 µM -0.294281153120586 0.36943334543442 no 2127 0.384271536500936 3017 3949838
SGTC_3251 9135047 49.47 µM -0.296058866653409 0.368692820898621 no 2128 0.383592563092019 3017 17682963
SGTC_1493 4348-0038 111 µM -0.296099350511924 0.368675962603122 no 2129 0.383577104988168 2979 800424
SGTC_3034 9090421 49.47 µM -0.29640375859302 0.368549209032949 no 2130 0.383460877643053 2927 17173761
SGTC_2472 5377652 49.4 µM -0.2971093347188 0.368255466678334 no 2131 0.383191518958116 2977 1610903
SGTC_2686 alizarin 95.37 µM -0.299301709708908 0.367343238746962 no 2132 0.382354925095264 2988 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1220 1838-0075 193 µM -0.300025811652954 0.367042110413067 no 2133 0.382078733599229 2958 5529645
SGTC_2937 9044753 11.33 µM -0.300160814678625 0.366985976479074 no 2134 0.382027246531794 2891 6465530 YGL099W LSG1
SGTC_799 1310-0557 151 µM -0.300733684682379 0.366747810155577 no 2135 0.38180879023041 3076 5354492
SGTC_635 k038-0028 24.7 µM -0.300790260773075 0.366724291859842 no 2136 0.381787217736897 2972 4035102
SGTC_1365 1672-3266 55.4 µM -0.301794335911024 0.366306987967564 no 2137 0.381404424481564 3049 6415873
SGTC_1872 amphotericin b 148 nM -0.303386783147399 0.365645474878416 no 2138 0.380797558425181 3064 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1369 1866-0067 208 µM -0.304207620992007 0.365304649274088 no 2139 0.380484859554905 3097 3531355
SGTC_2575 plumbagin 510 nM -0.304648986863962 0.365121430729495 no 2140 0.380316753117223 2897 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1418 3966-3099 2.4 µM -0.304810801113101 0.365054266569115 no 2141 0.38025512733172 3035 740335
SGTC_252 miconazole 1.30953 nM -0.305217054223518 0.364885661539212 no 2142 0.380100422173168 3043 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1362 1611-0397 101 µM -0.306198508292204 0.364478441816505 no 2143 0.379726754053754 2956 27816
SGTC_246 cycloheximide 667 µM -0.306528560698233 0.364341532552533 no 2144 0.379601118711346 2933 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2941 9056145 11.23 µM -0.306774467190771 0.364239539162005 no 2145 0.37950752200062 2949 2119517
SGTC_2081 5214970 32.255 µM -0.30750904776665 0.363934918174769 no 2146 0.379227968662595 3060 2063512
SGTC_852 0418-0143 439 µM -0.30769121166969 0.363859390474222 no 2147 0.379158653797023 3052 5369229
SGTC_1902 st060212 70.5 µM -0.307903789618833 0.363771259372524 no 2148 0.379077771048652 2974 688944
SGTC_204 PMA1.184 62.41 µM -0.308128021125377 0.363678304719995 no 2149 0.37899246003222 2961 2252213 YGL008C PMA1
SGTC_207 4185-0010 4.486 µM -0.308990264954575 0.363320938326448 no 2150 0.378664466082724 3034 3761753
SGTC_2920 7982904 15.77 µM -0.312153992476424 0.362010717715532 no 2151 0.377461747482806 3066 6456808
SGTC_1202 1988-0068 29.6 µM -0.312197614090623 0.361992663592078 no 2152 0.377445172618213 2951 2850480
SGTC_2318 6029776 164 µM -0.312531902417256 0.361854318461067 no 2153 0.377318160885536 3149 818325
SGTC_1870 st057514 26.5 µM -0.312611595921162 0.361821339990587 no 2154 0.377287883563246 2922 5393161
SGTC_523 1934-0222 13.7 µM -0.312666021659429 0.361798818322914 no 2155 0.377267206456661 2962 1361595
SGTC_1728 st035614 33.7865 µM -0.31362643066305 0.361401474644939 no 2156 0.376902391450808 3037 15945546
SGTC_3079 9117512 49.47 µM -0.315102447786596 0.360791103274243 no 2157 0.376341935028793 2984 7185044
SGTC_882 0843-0131 351 µM -0.315337983079911 0.360693736070816 no 2158 0.376252524330718 2982 5425421
SGTC_2638 epoxomicin 18 µM -0.317046969355395 0.359987534349948 no 2159 0.375603981421388 3062 9915668 A protesome inhibitor.
SGTC_3134 9127454 49.47 µM -0.317746975200497 0.359698409777134 no 2160 0.375338437643758 3067 24262820
SGTC_3258 9138477 49.47 µM -0.320282641577094 0.358651772452017 no 2161 0.374377040336975 3007 4970355
SGTC_2433 5607874 27.82 µM -0.320475065335958 0.358572389633491 no 2162 0.37430411470528 2966 2252428
SGTC_2287 7945887 168.79 µM -0.320638944375494 0.358504787518744 no 2163 0.374242010626912 3068 1245853
SGTC_1754 st042065 16.137 µM -0.321656211821152 0.35808525147065 no 2164 0.37385657704738 3030 1126236 YIL048W NEO1
SGTC_2653 dihydrofissinolide 100 µM -0.323125819989362 0.357479466071107 no 2165 0.373299978357892 3040 6857746
SGTC_147 4466-0538 29.23 µM -0.324123349806138 0.357068479913185 no 2166 0.372922324886229 3197 6742687 YHR072W ERG7
SGTC_1185 1319-0113 81.3 µM -0.325328815064068 0.356572044812062 no 2167 0.372466112356046 3077 4672763
SGTC_711 k292-0785 179 µM -0.32629585607471 0.356173973191623 no 2168 0.372100261593481 2948 4146315
SGTC_1051 3253-3903 78 µM -0.326815379014026 0.355960182057565 no 2169 0.371903763419772 2921 5509239
SGTC_2657 nystatin 74.44 µM -0.327518898866494 0.355670745749294 no 2170 0.371637725627286 3039 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3112 9123419 49.47 µM -0.32779411829238 0.355557539883218 no 2171 0.371533667385247 2963 17015854
SGTC_155 k072-0202 43.6 µM -0.328104176070521 0.355430019237638 no 2172 0.371416448288797 3012 5857737
SGTC_1590 st077108 57.8 µM -0.328197208014231 0.355391760190765 no 2173 0.371381279361586 3088 5489485
SGTC_1943 st076331 65.2 µM -0.329905760562949 0.354689383695428 no 2174 0.370735585335994 3100 24208415
SGTC_6 0844-0013 19.835 µM -0.330107735511139 0.354606385499035 no 2175 0.370659279233965 3067 1584900
SGTC_1588 farnesol 29.9 µM -0.330309533020846 0.354523467111246 no 2176 0.370583045248888 2976 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1483 3453-0561 55.9 µM -0.331160202029901 0.354174003919622 no 2177 0.370261739945175 3078 4546991
SGTC_1985 st071382 65.5 µM -0.332473784628983 0.353634612525723 no 2178 0.36976576588062 3011 6123237
SGTC_592 k241-0073 46.5 µM -0.333754697020324 0.35310891921314 no 2179 0.369282335764949 3117 4230158
SGTC_1322 1348-1070 12 µM -0.33407983103669 0.352975527020286 no 2180 0.369159659542281 3121 6758089
SGTC_3173 9105693 49.47 µM -0.334259991757327 0.352901620559025 no 2181 0.369091688888792 3153 17096658
SGTC_1353 1498-1206 8.11 µM -0.335291882450612 0.352478420032481 no 2182 0.368702458282407 3025 6756808
SGTC_2241 6772625 37.8075 µM -0.337461097251944 0.351589374226008 no 2183 0.367884666908619 2973 2285411
SGTC_3007 9078383 71.4286 µM -0.339676445535131 0.350682257865738 no 2184 0.367050100943176 3021 6496995
SGTC_3337 9144342 33.5465 µM -0.341020475601993 0.350132333501567 no 2185 0.366544083695537 3103 17682949
SGTC_581 0958-0271 211 µM -0.34120161330926 0.350058243054184 no 2186 0.366475904419456 3010 4591145
SGTC_1651 st011928 86.1 µM -0.342437193164474 0.349553008310541 no 2187 0.366010951191417 3112 720198
SGTC_469 w7 172 µM -0.342778319232829 0.349413567052489 no 2188 0.365882618821802 3032 45115570 A P450 inhibitor.
SGTC_3186 9110464 49.47 µM -0.343453320122621 0.349137708510826 no 2189 0.365628726251427 3135 17018021
SGTC_641 4092-0595 30 µM -0.343891057046446 0.348958857306313 no 2190 0.365464108805487 3085 786260
SGTC_1545 lovastatin 49.4 µM -0.344059819344176 0.348889913113877 no 2191 0.365400649863287 3092 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1672 st016598 6.51 µM -0.344512368238593 0.348705058666406 no 2192 0.365230498091608 3031 4665860 YNL267W PIK1
SGTC_1455 4262-0120 131 µM -0.345843070446899 0.348161709640359 no 2193 0.364730327296208 3176 1529587
SGTC_3179 9107801 49.47 µM -0.346638890158346 0.347836911297241 no 2194 0.364431312606278 3008 4818259
SGTC_280 3448-3607 3.04 µM -0.34729715434455 0.347568337908527 no 2195 0.364184044203835 3113 626179
SGTC_1817 st052116 64.4 µM -0.349247170381812 0.346773176007391 no 2196 0.363451878065026 3158 4361398
SGTC_125 0133-0007 11.75 µM -0.349833221859881 0.346534332285524 no 2197 0.363231932537809 3153 26541
SGTC_1135 dihydrocapsaicin 536.708 nM -0.350424595742483 0.346293381260674 no 2198 0.363010035213431 2958 107982 A Capsaicinoid.
SGTC_66 0109-0187 42.4 µM -0.352216124444759 0.345563815767916 no 2199 0.362338092620396 2987 759417
SGTC_2459 5811157 9.22 µM -0.352282961461569 0.345536608758757 no 2200 0.362313032477107 3023 2870684 YBR192W RIM2
SGTC_917 harmaline 728.087 nM -0.355985253009193 0.344030785292046 no 2201 0.360925804562985 3119 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3290 9121031 71.43 µM -0.356045262568397 0.344006398039992 no 2202 0.360903334319899 3065 17014854
SGTC_1179 1021-1431 9.29 µM -0.356068505691488 0.343996952454199 no 2203 0.360894631191721 3112 2840958
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.356226041556919 0.343932935287452 no 2204 0.360835645542841 3137 616764
SGTC_930 2810-3379 265 µM -0.356365664798895 0.34387620093534 no 2205 0.360783369626999 3238 1015764
SGTC_682 0kpi-0099 17 µM -0.357067574121958 0.343591041163718 no 2206 0.360520609302802 3117 1714895 YML126C ERG13
SGTC_2058 5236698 133 µM -0.358239018914877 0.343115324762588 no 2207 0.360082224702315 3051 766665
SGTC_1391 3442-0225 151 µM -0.358707613085774 0.342925101151536 no 2208 0.359906916253642 3012 5227075
SGTC_646 4092-0839 27.3 µM -0.360173769659734 0.342330179073597 no 2209 0.359358594495928 3188 877796
SGTC_611 3453-1652 23.7 µM -0.360766289691413 0.342089863197191 no 2210 0.359137082484851 3144 1560575
SGTC_680 0417-1641 114 µM -0.360847130623191 0.342057080469026 no 2211 0.359106863990152 3004 2835990
SGTC_1462 k081-0014 26.5 µM -0.361577512325948 0.341760949051104 no 2212 0.358833885894884 3048 3270634
SGTC_157 1348-1695 65.819 µM -0.361810836286484 0.341666368947818 no 2213 0.358746696909948 3068 5380510
SGTC_263 alizarin 107.927 µM -0.361825935201015 0.341660248800472 no 2214 0.358741054969538 3085 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1518 st038567 90.8 µM -0.366712389577062 0.339681782961012 no 2215 0.356916781960241 3113 77966
SGTC_2642 cholecalciferol 100 µM -0.367199515326917 0.339484792477007 no 2216 0.356735100410881 3144 9821465 A vitamin D precursor, similar to steriods.
SGTC_1669 st015249 58.4 µM -0.367972712213577 0.339172206738428 no 2217 0.356446790670255 3148 722793
SGTC_1935 st074532 41.6 µM -0.36955667916258 0.338532191042215 no 2218 0.355856417173058 3154 2829742
SGTC_1640 st009078 66.4 µM -0.371038448311661 0.337933891118272 no 2219 0.355304447409358 3174 690618
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.371138866266645 0.337893359742785 no 2220 0.355267051957221 3023 5355888
SGTC_291 SEC14.278 35.5 µM -0.37127751566539 0.337837400222005 no 2221 0.355215421480041 3178 1068044
SGTC_617 3770-0098 35 µM -0.371589388974366 0.337711539851961 no 2222 0.355099295329726 3074 5962639
SGTC_867 0518-0118 155 µM -0.372102906292921 0.337504343067452 no 2223 0.354908116277741 3159 6848158
SGTC_2003 4023581 200 µM -0.372906652232021 0.337180142142836 no 2224 0.354608960401902 3189 16641307
SGTC_1849 st056239 19.2 µM -0.374576021228557 0.336507167860877 no 2225 0.353987904522307 3040 5393181
SGTC_141 0443-0274 32.331 µM -0.374842886484833 0.336399634685996 no 2226 0.353888658509084 3223 1627241
SGTC_2030 5175110 200 µM -0.37492477311358 0.336366641206697 no 2227 0.353858207222732 3189 2831986
SGTC_1745 st081495 74 µM -0.375307826064008 0.336212319564587 no 2228 0.353715773245621 3099 13842402 YBL026W LSM2
SGTC_227 fluconazole 33.516 µM -0.375317901865752 0.336208260669794 no 2229 0.353712026947157 3108 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_364 0083-0097 67.7 µM -0.375502323741253 0.336133972288783 no 2230 0.353643459285171 3188 5207356
SGTC_560 2332-1943 155 µM -0.375593042925034 0.336097431351096 no 2231 0.353609731827339 3069 21177716
SGTC_1775 st081588 35.1725 µM -0.375824144259196 0.336004352641896 no 2232 0.353523818472922 3086 1426443 YGL099W LSG1
SGTC_2393 9031399 185.94 µM -0.376099192207025 0.335893587036977 no 2233 0.353421577417424 3203 1526623 YDL150W RPC53
SGTC_2088 5278280 127.392 µM -0.376604647873411 0.335690070231101 no 2234 0.353233716590585 3155 791502
SGTC_715 0868-0130 184 µM -0.377516053823378 0.335323223299198 no 2235 0.352895068126514 3221 2876258
SGTC_1810 st050138 53 µM -0.378088289232119 0.335092974951401 no 2236 0.352682503795836 3197 3444541
SGTC_1977 st070720 65.3 µM -0.378257352587878 0.335024961375894 no 2237 0.352619711797184 3173 682188
SGTC_1750 st081859 2.357 µM -0.378488880602424 0.334931827271631 no 2238 0.352533726249103 3117 5291695
SGTC_3109 9122853 49.47 µM -0.378607401056237 0.334884155343165 no 2239 0.352489712693405 3118 1234709
SGTC_2397 5161689 200 µM -0.378791260072044 0.334810207855272 no 2240 0.352421439028016 3275 2259942
SGTC_3088 9117578 49.47 µM -0.381906956773346 0.333558060901403 no 2241 0.351265189980529 3166 678341
SGTC_1413 3910-0535 34.4 µM -0.382319501174524 0.333392404672964 no 2242 0.351112195776263 3200 2876951
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.383850724537909 0.332777829845304 no 2243 0.350544544908448 3109 6708561
SGTC_2991 9074669 71.4286 µM -0.38454660969018 0.332498676313956 no 2244 0.350286678468231 3258 17333109
SGTC_173 1273-0061 2.693 µM -0.385634681452866 0.332062383745643 no 2245 0.34988362210725 3179 2847414 YPL266W DIM1
SGTC_1372 2752-0194 270 µM -0.385652614933761 0.332055194723543 no 2246 0.349876980391263 3101 823334
SGTC_1706 st031321 9.9705 µM -0.385699115399257 0.332036554298294 no 2247 0.349859759024725 3184 6103185
SGTC_2971 9092186 9.93 µM -0.386652016211939 0.331654660973247 no 2248 0.349506921927314 3035 25236400
SGTC_2689 tacrolimus 100 µM -0.387779484355235 0.331203032345471 no 2249 0.349089614485857 3148 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1453 4237-0541 195 µM -0.388124997544993 0.331064679620773 no 2250 0.348961766901107 3220 739892
SGTC_2816 7982706 58.44 µM -0.388748196294721 0.330815192494312 no 2251 0.348731212823142 3177 2981853
SGTC_1546 5-methoxyflavanone 78.7 µM -0.389500690091418 0.330514044403939 no 2252 0.348452900128172 3158 147795
SGTC_637 1181-0519 7.26 µM -0.389728817232256 0.330422769561943 no 2253 0.348368542541677 3120 6252091 YGR060W ERG25
SGTC_3103 9120822 49.47 µM -0.389732573694601 0.330421266666447 no 2254 0.348367153527726 3319 17141819
SGTC_738 1315-0003 72.4 µM -0.390078447136487 0.33028290041737 no 2255 0.348239269829625 3226 6251474
SGTC_1091 telmisartan 47.6 µM -0.390448568401771 0.33013485955668 no 2256 0.348102439819258 3204 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1336 1486-0901 104 µM -0.390629657217591 0.330062437457401 no 2257 0.348035500356343 3134 5006114
SGTC_1947 st076332 61.6 µM -0.391041247811269 0.329897855425381 no 2258 0.347883373548377 3215 24208416
SGTC_181 1447-1644 8.07 µM -0.392543840431144 0.329297295952722 no 2259 0.347328212640016 3195 534600
SGTC_2340 7987427 183.45 µM -0.392580659162658 0.32928258568113 no 2260 0.347314613376596 3219 2239331
SGTC_37 0566-0070 1.56 µM -0.393370574475637 0.328967052704358 no 2261 0.347022899843974 3159 1626686
SGTC_2017 5132927 60.65 µM -0.393447828267254 0.328936200086736 no 2262 0.346994375095906 3079 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_145 3737-0113 38.366 µM -0.393606082046321 0.328873002383658 no 2263 0.346935945083155 3230 6849351
SGTC_837 0091-0265 12.5 µM -0.394934585063065 0.328342665694308 no 2264 0.346445582593352 3100 759367
SGTC_982 1491-0518 27.5 µM -0.398276866069834 0.32700996229519 no 2265 0.345213055592803 3096 3091256
SGTC_2349 9023730 187.07 µM -0.398669468306484 0.326853560086248 no 2266 0.345068383752428 3256 4126287
SGTC_2688 kanamycin b 96.69 µM -0.399235529235066 0.326628110127681 no 2267 0.344859833167055 3278 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_657 3534-0529 86.7 µM -0.400479094549211 0.326133047031343 no 2268 0.344401839084414 3240 1049549
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.401010772926118 0.32592147938589 no 2269 0.344206096205099 3209 521171
SGTC_961 1252-1571 372 µM -0.401169494088271 0.325858331266694 no 2270 0.344147669457964 3279 6813498
SGTC_1402 3909-7673 35.9 µM -0.403471463838766 0.324943041845598 no 2271 0.343300711678292 3103 5328014
SGTC_95 0471-0001 561.058 µM -0.404205333164734 0.324651468678305 no 2272 0.343030866142748 3131 4015405
SGTC_2181 6316240 54.2555 µM -0.405095086323751 0.324298105484517 no 2273 0.342703809093594 3194 12779990
SGTC_2061 5245884 80.95 µM -0.405099487574536 0.324296357931928 no 2274 0.34270219156677 3099 573863
SGTC_778 3456-2434 196 µM -0.405232511490377 0.324243541525536 no 2275 0.342653304608787 3217 5539063
SGTC_1039 k821-0043 94 µM -0.40669637573399 0.323662556148866 no 2276 0.342115501358261 3240 15992768
SGTC_1043 0916-0009 19.3 µM -0.406860549531835 0.323597424834796 no 2277 0.34205520614511 3295 3101130
SGTC_2310 7668677 200 µM -0.407448820109782 0.323364089490469 no 2278 0.341839188305576 3331 2197143
SGTC_1165 k072-0275 30.3 µM -0.408377057994751 0.322996048662908 no 2279 0.341498436968175 3269 6153523 YGL055W OLE1
SGTC_2514 salinomycin 42.74 µM -0.408405450102131 0.322984794089168 no 2280 0.341488016406317 3274 23682228 A polyether potassium ionophore.
SGTC_2064 5220758 200 µM -0.4089273407558 0.322777946573534 no 2281 0.341296491964081 3277 788518
SGTC_3036 9090181 49.47 µM -0.409087525744081 0.322714469425766 no 2282 0.341237715162283 3118 25236586
SGTC_257 daunorubicin 18.5 µM -0.409252315261883 0.322649173013268 no 2283 0.341177252836072 3219 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3323 9138564 53.9225 µM -0.409549499918234 0.322531430004537 no 2284 0.341068224196474 3273 43912313 YNL103W MET4
SGTC_3008 9078912 71.4286 µM -0.410999296522344 0.321957283520416 no 2285 0.340536525267808 3133 16648731
SGTC_1241 0364-0022 50.8 µM -0.411242134007215 0.321861156842283 no 2286 0.340447497904395 3146 4563895
SGTC_713 1488-1073 324 µM -0.41367341900069 0.320899396100168 no 2287 0.339556648179636 3177 3312542
SGTC_1082 camptothecin 424.86 nM -0.414604941213024 0.320531224967512 no 2288 0.339215565182128 2936 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1711 st032263 62.8 µM -0.416414408318929 0.319816563097869 no 2289 0.338553393491776 3157 3958979
SGTC_2319 6033012 152.6 µM -0.417427028105309 0.319416913206603 no 2290 0.338183044386571 3117 847246
SGTC_2105 5350118 200 µM -0.419003754007065 0.318795045523715 no 2291 0.337606694402963 3179 2133313
SGTC_712 r015-0009 80.6 µM -0.42107952683073 0.317977129133448 no 2292 0.336848505446463 3243 6813872 YLR060W FRS1
SGTC_407 eburnamonine 100 µM -0.421465965746281 0.317824958505086 no 2293 0.336707429283319 3103 3195
SGTC_51 1013-0126 23.419 µM -0.423043473982405 0.317204091880633 no 2294 0.336131771318772 3404 1627850
SGTC_2457 5731572 11.68 µM -0.423360928256955 0.317079212137444 no 2295 0.336015973560929 3261 2865357
SGTC_270 tamoxifen 5.46 µM -0.423844029177515 0.31688921050752 no 2296 0.335839782759666 3342 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_369 0957-0393 4.5 µM -0.424085259816727 0.316794353547285 no 2297 0.335751817501765 3196 6997992
SGTC_2221 6807166 181.081 µM -0.425729830935132 0.316147994788094 no 2298 0.335152361203821 3201 674925
SGTC_953 1188-0045 9.7 µM -0.427406387960039 0.315489642620915 no 2299 0.334541677732592 3254 6144426
SGTC_2191 5911152 200 µM -0.428366018540894 0.315113077095329 no 2300 0.334192330440819 3213 2875902
SGTC_2923 7992654 58.14 µM -0.42836824232587 0.315112204689974 no 2301 0.334191521052959 3168 2985126
SGTC_3044 9093193 49.47 µM -0.42849615589472 0.315062025098152 no 2302 0.334144965830669 3233 25236277
SGTC_616 4092-0450 108 µM -0.430648030648413 0.314218372037126 no 2303 0.333362155887551 3208 787165
SGTC_2909 7941780 10.49 µM -0.430959736476415 0.314096246540578 no 2304 0.333248823457982 3314 1243215
SGTC_2975 9084847 53.72 µM -0.431689522807956 0.313810397869736 no 2305 0.332983541626616 3226 27211724
SGTC_686 1319-0111 510 µM -0.432050970199914 0.313668864560045 no 2306 0.332852184205755 3315 4562600
SGTC_1569 carminic acid 40.6 µM -0.43226697181569 0.313584297086306 no 2307 0.332773694563899 3319 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2271 7849410 118.62 µM -0.435114368333244 0.312470421015675 no 2308 0.33173970729035 3314 972430
SGTC_1496 4469-0713 57.4 µM -0.435780869706563 0.312209938407657 no 2309 0.33149786245665 3271 746691
SGTC_3312 9133330 71.43 µM -0.436078821623022 0.312093522942439 no 2310 0.331389771164478 3297 17617324
SGTC_2051 5263410 176 µM -0.436429478971643 0.311956538500428 no 2311 0.331262577333298 3299 227584
SGTC_3125 9127534 49.47 µM -0.437592049340862 0.31150256599598 no 2312 0.330841017852041 3219 1639235
SGTC_1519 esterone 74 µM -0.438465063415244 0.311161850677185 no 2313 0.330524595268279 3136 698 A steroid.
SGTC_2479 5617353 43.85 µM -0.438909084852485 0.310988622371868 no 2314 0.330363706840595 3323 2731746
SGTC_2225 6654152 15.4 µM -0.43893076561123 0.310980165020834 no 2315 0.330355851754048 3222 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_3256 9138902 49.47 µM -0.439045194368571 0.310935529668293 no 2316 0.330314394674438 3194 17228773
SGTC_2534 helenine 20.12 µM -0.440309512589922 0.310442540916858 no 2317 0.329856475988879 3161 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1635 st007035 42.4 µM -0.444444092852802 0.308832746172419 no 2318 0.328360770355493 3267 3716403
SGTC_3169 9102970 49.47 µM -0.445357535817028 0.308477591369691 no 2319 0.328030697300427 3284 17027839
SGTC_492 tmb-8 126 µM -0.445400253485153 0.308460986739989 no 2320 0.328015264534683 3207 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2272 7805186 180 µM -0.445828609265362 0.308294503785335 no 2321 0.32786052713843 3304 2956062 YPR165W RHO1
SGTC_1012 4112-3522 18 µM -0.446672660490056 0.307966573784028 no 2322 0.327555712205862 3321 3112398
SGTC_984 1492-0255 2.91 µM -0.448552737999061 0.307236679058507 no 2323 0.326877167023955 3270 1585198
SGTC_1898 st060199 18.6 µM -0.449157168973791 0.307002185246375 no 2324 0.326659141192688 3181 688866
SGTC_1356 1502-0781 85.8 µM -0.450360906563535 0.306535420827206 no 2325 0.32622511430907 3186 567702
SGTC_2047 4141938 200 µM -0.450575513190209 0.306452237327257 no 2326 0.326147759142451 3206 3807862
SGTC_723 4182-0001 115 µM -0.450748986347365 0.306385004826058 no 2327 0.326085236041246 3203 744821 YLR208W SEC13
SGTC_3003 9075612 71.4286 µM -0.451601912508599 0.306054533482053 no 2328 0.325777895994201 3247 6501993
SGTC_1616 st002734 56.1 µM -0.451631582466442 0.306043040517815 no 2329 0.325767206967889 3171 4026101
SGTC_3171 9103192 49.47 µM -0.451659594828836 0.306032189815503 no 2330 0.325757115245476 3311 13018434
SGTC_943 3253-1379 105 µM -0.451752361753179 0.305996257385857 no 2331 0.325723695982196 3332 668464
SGTC_2236 dapsone 200 µM -0.452666444870887 0.305642295423837 no 2332 0.325394472672758 3273 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3093 9117344 49.47 µM -0.452671126108475 0.305640483167208 no 2333 0.32539278699204 3311 24824913
SGTC_2860 9025725 38.96 µM -0.45363251884567 0.305268398266859 no 2334 0.325046671971158 3145 40546248
SGTC_1276 0871-0068 94.2 µM -0.454342268917414 0.304993834885477 no 2335 0.3247912486965 3243 3414906
SGTC_1105 epirubicin 18.1 µM -0.455633783307717 0.304494500401462 no 2336 0.324326672718401 3177 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2425 5628681 7.85 µM -0.455788564767708 0.304434682110433 no 2337 0.324271013967435 3262 5714958
SGTC_348 k064-0012 10.7 µM -0.455873933059317 0.304401692119902 no 2338 0.324240317574859 3187 5066323
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.458576822689711 0.303358002981717 no 2339 0.323269041822364 3316 5282362
SGTC_3014 9081533 49.47 µM -0.458710644489605 0.303306370833313 no 2340 0.323220984549111 3323 21367265
SGTC_121 0557-0495 61.343 µM -0.459825607585246 0.302876340050102 no 2341 0.322820700504993 3248 3104427
SGTC_562 3772-2733 112 µM -0.461680544840161 0.302161513702932 no 2342 0.322155212372725 3322 2876874 YIL048W NEO1
SGTC_2883 9059145 45.46 µM -0.462087155866322 0.302004921635724 no 2343 0.322009410285587 3161 16476510
SGTC_2803 7707263 71.43 µM -0.462225757813424 0.301951552256717 no 2344 0.321959716827029 3174 2199229
SGTC_1702 st027038 51 µM -0.462777153181345 0.30173927665618 no 2345 0.321762054578891 3273 5521182
SGTC_2777 climbazole 1.536 µM -0.464341497998072 0.301137402373823 no 2346 0.321201548476181 3290 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2926 9010726 65.15 µM -0.464687842697801 0.301004221060793 no 2347 0.321077507862146 3321 2994293
SGTC_253 dyclonine 31.25 µM -0.466781217881171 0.300199813032755 no 2348 0.32032820747046 3312 3180 An oral anasthetic.
SGTC_2335 9018011 154.17 µM -0.468005373307 0.299729865418127 no 2349 0.319890373573173 3279 6458208
SGTC_1294 1000-1494 117 µM -0.468422904843187 0.299569653228621 no 2350 0.319741095728578 3257 712797 YDL207W GLE1
SGTC_213 1246-0773 967 nM -0.468630710397736 0.299489930047022 no 2351 0.319666810985445 3266 6251622
SGTC_3275 9138069 49.47 µM -0.469481484878822 0.299163636567121 no 2352 0.319362758078958 3309 17617007
SGTC_2244 6635614 200 µM -0.472147380210981 0.298142244897869 no 2353 0.318410797751507 3084 836499
SGTC_44 0929-0055 61.211 µM -0.472247797921179 0.298103802652978 no 2354 0.318374963120478 3180 1379590
SGTC_91 0417-1751 58.384 µM -0.473896461891983 0.297472978751807 no 2355 0.317786871188208 3333 6795624
SGTC_3050 9093513 49.47 µM -0.474716599747943 0.297159398797468 no 2356 0.317494492293533 3293 25236664
SGTC_1116 jasmonic acid 1.58368 µM -0.475751374882721 0.296763967977062 no 2357 0.317125757679577 3341 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1028 k015-0029 4.8 µM -0.47653869859287 0.296463260158464 no 2358 0.316845322142467 3236 4588309
SGTC_2488 5268135 45.7 µM -0.477542975561125 0.296079892730084 no 2359 0.316487763071764 3336 1270356 YLR208W SEC13
SGTC_753 1322-0200 289 µM -0.478158486211997 0.295845043426812 no 2360 0.316268703645895 3372 5403907
SGTC_3001 9076041 71.4286 µM -0.478632070510805 0.295664404666811 no 2361 0.316100199497579 3258 16004211
SGTC_3278 9139605 49.47 µM -0.478943270758843 0.295545731491327 no 2362 0.315989493365013 3397 7958859
SGTC_1421 4029-0249 71.4 µM -0.480203797318374 0.295065266176024 no 2363 0.315541243484654 3394 2894095
SGTC_1522 st012842 45.6 µM -0.480348831358182 0.295010007740744 no 2364 0.315489686006332 3205 3491067 YOR116C RPO31
SGTC_1963 st076565 50.3 µM -0.480396388570481 0.294991889327991 no 2365 0.315472780895366 3223 4914280
SGTC_2375 9072683 200 µM -0.48078916608149 0.294842268012517 no 2366 0.315333175466981 3403 16798029
SGTC_983 1491-0821 12.2 µM -0.481053067986992 0.294741759122877 no 2367 0.315239391269808 3333 46495113
SGTC_2045 5106652 78.05 µM -0.481077531323861 0.294732442889851 no 2368 0.31523069820901 3330 673349
SGTC_484 loperamide 105 µM -0.481088700696993 0.294728189366352 no 2369 0.315226729199875 3264 3955 An opioid-receptor agonist.
SGTC_1104 tacrolimus 29.8 µM -0.483091517562203 0.293965934215383 no 2370 0.314515378324927 3343 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2426 5582046 32.21 µM -0.483656367451864 0.293751122037826 no 2371 0.314314881925966 3387 2251934
SGTC_1969 st069479 40.1 µM -0.484378487130893 0.293476606062557 no 2372 0.314058641568388 3363 3895485
SGTC_3154 9100113 49.47 µM -0.485961586341059 0.292875202297556 no 2373 0.313497200881743 3224 25237525
SGTC_1155 4088-0394 48.2 µM -0.487882884045855 0.292146089639526 no 2374 0.312816399339552 3236 2326248
SGTC_2233 sulbentine 40.3845 µM -0.487919383573995 0.292132246624413 no 2375 0.312803472095306 3303 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2821 7996764 71.43 µM -0.488358083921289 0.291965886566748 no 2376 0.312648113129337 3463 2987135
SGTC_1469 k284-2957 126 µM -0.488633824186421 0.291861345369616 no 2377 0.312550480996406 3297 23884841
SGTC_2368 9071271 200 µM -0.488675404145786 0.291845582704233 no 2378 0.312535759804146 3278 27209959
SGTC_1247 0448-0043 5.84 µM -0.49110905616938 0.290923694279345 no 2379 0.311674658308027 3340 3089013 YGL099W LSG1
SGTC_1842 st055362 61.2 µM -0.491140646788376 0.290911736432319 no 2380 0.311663487322196 3251 676032
SGTC_3120 9124077 49.47 µM -0.491805928047227 0.290659964048854 no 2381 0.311428272706992 3346 18774327 YGL155W CDC43
SGTC_3110 9122132 49.47 µM -0.493489649463529 0.29002322387655 no 2382 0.310833325777863 3437 918317
SGTC_2833 9001315 45.46 µM -0.494335879277849 0.289703448614042 no 2383 0.310534494984212 3206 2989378
SGTC_1732 st034308 51.822 µM -0.4944001881567 0.289679154194111 no 2384 0.310511790571533 3180 830119
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.495185452485142 0.289382576490041 no 2385 0.310234609254796 3359 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_800 3448-7362 155 µM -0.495275057444677 0.289348743664739 no 2386 0.310202987490273 3390 15991913
SGTC_633 0437-0093 97.7 µM -0.49600415880817 0.289073520438025 no 2387 0.309945738382488 3304 2831118
SGTC_2730 imipramine 71.33 µM -0.496865920980882 0.288748378893576 no 2388 0.309641802459382 3381 3696 A tricyclic antidepressant.
SGTC_690 glyoxal 20.3 µM -0.49714412332675 0.288643450355307 no 2389 0.309543710717727 3323 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_331 k048-0133 24.5 µM -0.49921495795318 0.287862966373865 no 2390 0.308813979033099 3281 6813582
SGTC_1047 2043-3044 82 µM -0.500284705770517 0.287460176240986 no 2391 0.308437310831247 3274 669592
SGTC_1798 st045719 60.953 µM -0.500363390249894 0.287430559848617 no 2392 0.308409613243801 3336 3980186
SGTC_2007 4011539 71.82 µM -0.5012120231467 0.287111230988436 no 2393 0.30811095677511 3291 45595301
SGTC_812 4251-0442 148 µM -0.501314369741417 0.287072730729237 no 2394 0.308074946867535 3368 5723007
SGTC_1473 k844-0725 134 µM -0.502884908766218 0.286482239592281 no 2395 0.307522595967171 3394 54682906
SGTC_2214 7179297 48.276 µM -0.503127631785747 0.286391032052882 no 2396 0.307437270346676 3336 769744
SGTC_3078 9116413 49.47 µM -0.503694189030604 0.286178191627505 no 2397 0.307238146234445 3266 17177322
SGTC_2709 st078560 56 µM -0.504077677756715 0.286034167806829 no 2398 0.307103396240036 3425 17250903
SGTC_2654 protoveratrine a 100 µM -0.505381291474574 0.285544837665888 no 2399 0.306645528228724 3309 5702278 A heart drug and vasodilator.
SGTC_757 1066-0008 322 µM -0.506220667339311 0.285229976898732 no 2400 0.306350873951621 3382 6842497
SGTC_818 4072-2707 53.5 µM -0.506300365006454 0.285200089872305 no 2401 0.306322903408462 3262 882871
SGTC_2264 7948757 110.76 µM -0.506661092930988 0.2850648337517 no 2402 0.306196317132275 3215 2971411
SGTC_225 nsc-122657 1.016 µM -0.507092051176732 0.284903284644853 no 2403 0.306045116032225 3360 275685
SGTC_2011 4012611 177 µM -0.508291979040337 0.284453709635249 no 2404 0.305624297142069 3274 2049887
SGTC_2499 avocadenofuran 51.48 µM -0.509532390359319 0.283989323316709 no 2405 0.305189550284153 3250 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1394 3474-0001 65.7 µM -0.510218662358217 0.283732552142193 no 2406 0.304949139520624 3303 5017666 YIL048W NEO1
SGTC_741 4582-0002 126 µM -0.510275166193587 0.28371141598057 no 2407 0.304929349178871 3291 2912688
SGTC_1604 st002052 72.4 µM -0.510901885048964 0.283477032367733 no 2408 0.304709880577312 3429 6254834 YHR062C RPP1
SGTC_3099 9120367 49.47 µM -0.513025448936955 0.282683541512279 no 2409 0.303966759517337 3383 24824940
SGTC_2151 5563267 85.4165 µM -0.513157869736216 0.282634096533314 no 2410 0.303920446889374 3319 5310824
SGTC_363 0455-0021 3.06 µM -0.51447354914566 0.282143057209839 no 2411 0.303460474440269 3362 4597466
SGTC_421 streptovitacin 30 mM -0.515249375520151 0.281853695055705 no 2412 0.303189384937031 3436 91467 include heat shock
SGTC_689 0833-0039 98 µM -0.51562354986768 0.281714189326826 no 2413 0.303058679535481 3358 5374726
SGTC_742 0kpi-0133 140 µM -0.515663405807626 0.28169933155295 no 2414 0.30304475867011 3413 2728852
SGTC_1001 4048-4355 44.4 µM -0.516101406033778 0.281536075682775 no 2415 0.302891792993665 3343 21824233
SGTC_819 1013-0258 27.7 µM -0.516601731063338 0.281349645342336 no 2416 0.302717103524757 3335 5753198
SGTC_2876 9059903 25.97 µM -0.517713278608402 0.280935675580936 no 2417 0.302329166121515 3393 6916095
SGTC_3182 9108849 49.47 µM -0.517841991829827 0.280887758391609 no 2418 0.302284258772056 3411 17133045
SGTC_167 3672-0051 66.205 µM -0.518639813743302 0.280590834468137 no 2419 0.302005969801234 3313 3237971
SGTC_579 4491-1009 110 µM -0.521926911320916 0.279369085827941 no 2420 0.300860610108326 3474 1271041
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.522712913035697 0.279077327980768 no 2421 0.30058702537722 3460 1377
SGTC_2934 9036370 36.88 µM -0.522949287559106 0.278989616545754 no 2422 0.300504772135974 3350 6462800
SGTC_2549 cedrol 20.94 µM -0.523481002345688 0.278792362291922 no 2423 0.300319784009015 3401 6708665 A sedative which affects the nervous system.
SGTC_1630 st005209 31.3 µM -0.524099840010761 0.278562872911999 no 2424 0.300104549916689 3444 3367314
SGTC_187 1488-2104 32.728 µM -0.524412556264636 0.278446940413893 no 2425 0.299995812557546 3372 2852859
SGTC_2694 st077685 81.9 µM -0.5248885307805 0.278270528732979 no 2426 0.299830341437519 3266 2838096
SGTC_1109 tnp00067 928.257 nM -0.525279252521424 0.278125755246826 no 2427 0.299694539081774 3358 676295
SGTC_1118 chelidonine 707.474 nM -0.525877314234976 0.277904227598718 no 2428 0.299486725977511 3423 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1352 1496-0991 99 µM -0.526140834174837 0.277806644692276 no 2429 0.29939517941435 3344 3000039
SGTC_2352 9027995 87.8 µM -0.526767000528337 0.277574838921476 no 2430 0.299177700768078 3341 2997347
SGTC_3335 9143315 29.6265 µM -0.5306634961862 0.276134490170344 no 2431 0.297825993138351 3327 4899691
SGTC_101 0490-5701 117.494 µM -0.53111914941999 0.275966296789957 no 2432 0.29766810753675 3388 4661669
SGTC_998 3996-0085 177 µM -0.531176414338765 0.275945162388648 no 2433 0.297648267723639 3331 715391
SGTC_1041 0206-0046 107 µM -0.531363217221642 0.275876225757352 no 2434 0.297583552814116 3349 50494
SGTC_980 1473-0395 201 µM -0.532445898052489 0.275476846330975 no 2435 0.29720860168401 3336 768876
SGTC_1703 st026983 48.3 µM -0.533912771989424 0.274936199809234 no 2436 0.296700942592361 3453 1104023
SGTC_2216 7189485 200 µM -0.535177937441957 0.274470317418887 no 2437 0.296263410421645 3409 731273
SGTC_553 k007-0256 45.7 µM -0.536347461380468 0.274040000693536 no 2438 0.295859217357261 3376 6287000
SGTC_1233 0325-0408 14.2 µM -0.536761589310272 0.273887705689071 no 2439 0.295716153509614 3429 12874
SGTC_969 1313-0238 134 µM -0.538073983763744 0.273405350934914 no 2440 0.295262986355096 3333 5212874
SGTC_1103 duloxetine 36.1 µM -0.538345115939877 0.273305752023169 no 2441 0.295169404815113 3476 60835 A selective serotonin reuptake inhibitor.
SGTC_190 3970-0790 3.722 µM -0.538792381694439 0.273141490694976 no 2442 0.295015060447473 3411 2832352
SGTC_1553 gossypol 38.6 µM -0.539109183121545 0.273025172865834 no 2443 0.294905759763209 3379 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1516 st013856 110 µM -0.539474305234366 0.272891143924837 no 2444 0.294779810957122 3400 5281404 A mutagen and neurotoxin.
SGTC_1667 st014849 34.6 µM -0.540083803238438 0.272667482260732 no 2445 0.294569620004375 3427 5348460
SGTC_1488 4013-0813 75.9 µM -0.540564097580754 0.272491297345694 no 2446 0.294404034847851 3342 2910057
SGTC_2752 diclazuril 33.15 µM -0.540591548461756 0.27248122933041 no 2447 0.294394572244531 3410 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2455 5377712 9.75 µM -0.540738029900901 0.272427508226157 no 2448 0.29434408094756 3394 2243908
SGTC_1900 st060200 72.8 µM -0.540998156787991 0.272332121368367 no 2449 0.294254426585373 3362 688945
SGTC_168 3970-0862 530.542 µM -0.541033763761931 0.272319065811028 no 2450 0.294242155400166 3406 3135186
SGTC_847 0342-0274 5.54 µM -0.542006132908699 0.271962659792129 no 2451 0.293907140494716 3430 18097
SGTC_2138 5575593 77.673 µM -0.542298674561194 0.271855478848313 no 2452 0.293806384277519 3373 762213
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.54233437662689 0.271842399821533 no 2453 0.293794088985708 3396 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1304 1165-0502 251 µM -0.54234050610341 0.271840154392264 no 2454 0.293791978103714 3344 767425
SGTC_1926 methyl fluorone black 53.6 µM -0.54427471306472 0.271132051906297 no 2455 0.293126222621069 3325 72721 Reacts with homocysteine.
SGTC_1972 st070201 17.4 µM -0.545522269787925 0.270675816745031 no 2456 0.292697184174345 3436 2829099
SGTC_139 0099-0334 718.624 µM -0.54554604495777 0.270667125819578 no 2457 0.29268901065598 3440 97690
SGTC_1120 ficusin 1.78878 µM -0.545587610694058 0.27065193195311 no 2458 0.292674721283669 3437 6199 A DNA cross-linker.
SGTC_3264 9137442 49.47 µM -0.545615784612356 0.270641633550553 no 2459 0.292665035903713 3514 17015726
SGTC_1056 3448-1962 115 µM -0.546449102173896 0.270337119798705 no 2460 0.292378632726764 3414 715507
SGTC_1193 1488-0126 41.5 µM -0.546522103756712 0.270310451472438 no 2461 0.292353548999171 3411 1384710
SGTC_2411 st077133 39.94 µM -0.546667158666465 0.270257465132153 no 2462 0.292303710339601 3563 1403142 YNL221C POP1
SGTC_463 ikarugamyin 104 µM -0.546988125200592 0.27014023942813 no 2463 0.292193445170682 3430 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_401 neomycin 50 µM -0.54740390494202 0.269988423185744 no 2464 0.292050636556054 3395 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1173 0443-0020 122 µM -0.549002703264559 0.26940504205313 no 2465 0.291501797336193 3371 5331295
SGTC_2228 7354201 200 µM -0.549473958987015 0.269233207513541 no 2466 0.291340115412694 3424 753451
SGTC_701 4424-0219 185 µM -0.551109238009496 0.268637360451379 no 2467 0.290779396522943 3495 2911779
SGTC_2355 9061122 103.12 µM -0.553685585853767 0.26769996223999 no 2468 0.289897020817595 3425 5302957
SGTC_904 1141-0088 396 µM -0.554816701686955 0.267288929722333 no 2469 0.289510021026912 3408 1378119
SGTC_1273 0849-0096 14.1 µM -0.555014714842509 0.267217007130537 no 2470 0.289442297799473 3415 5286025
SGTC_2684 capsaicin 100 µM -0.555418787287673 0.26707026972872 no 2471 0.289304122547215 3468 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3124 9127567 49.47 µM -0.556035625586832 0.266846345688468 no 2472 0.289093250401468 3452 17592030
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.556131180377543 0.266811665968909 no 2473 0.289060590538276 3491 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1244 0416-0015 52.5 µM -0.55631385830407 0.266745372971523 no 2474 0.288998157514768 3381 96201
SGTC_2478 5763493 32.33 µM -0.558226234707897 0.266051880301205 no 2475 0.28834495425762 3406 1365576 YLR208W SEC13
SGTC_1665 st014639 11.4 µM -0.559510109320917 0.265586816596322 no 2476 0.287906816915026 3507 981133 YIL048W NEO1
SGTC_3224 9130643 49.47 µM -0.559928301283388 0.265435422104948 no 2477 0.287764171885264 3522 17644395
SGTC_1296 1068-0102 11.9 µM -0.561125503547639 0.265002251383341 no 2478 0.287355991625925 3423 767053
SGTC_1333 1482-0047 286 µM -0.562814989247005 0.264391574742338 no 2479 0.28678043619107 3480 3811116
SGTC_688 0527-0193 473 µM -0.567159103355441 0.262824659409005 no 2480 0.285303045329539 3392 4007154
SGTC_328 k915-0120 63.5 µM -0.567228932645674 0.26279951092846 no 2481 0.285279326707202 3473 6624543
SGTC_56 0957-0365 83.25 µM -0.567671078296926 0.262640304152655 no 2482 0.285129166756732 3474 6752360
SGTC_1479 0549-0158 134 µM -0.568156275948051 0.262465652124229 no 2483 0.284964429005365 3463 5440202
SGTC_2028 5153890 36.43 µM -0.569269514374037 0.262065155008479 no 2484 0.284586626041218 3446 2830968 YPR165W RHO1
SGTC_1148 3909-7663 27.7 µM -0.569434662984214 0.262005768065005 no 2485 0.284530599456686 3523 4084526
SGTC_2120 5538279 151.968 µM -0.570913351556186 0.261474343705074 no 2486 0.284029189983034 3487 2058197
SGTC_2155 5570423 76 µM -0.571349019973744 0.261317874901238 no 2487 0.283881539557591 3380 797402
SGTC_2756 carbadox 75.1 µM -0.571431176668117 0.261288374000091 no 2488 0.283853700319291 3420 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2293 7624732 200 µM -0.572057651689387 0.261063475054882 no 2489 0.283641458873582 3444 894453
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.572404349593912 0.260939056387658 no 2490 0.283524034897397 3426 5106787 A p450 inhibitor.
SGTC_1758 st042942 75.2445 µM -0.573479444849168 0.260553433450021 no 2491 0.283160056407636 3467 669317
SGTC_1845 st056753 3.01 µM -0.574101394337979 0.260330482151557 no 2492 0.282949594933652 3373 5375839
SGTC_1020 4335-0961 93.3 µM -0.574235191618222 0.260282532460609 no 2493 0.282904329093278 3322 669075
SGTC_2621 lithochol-11-enic acid 100 µM -0.575411696916281 0.259861097598147 no 2494 0.282506447624601 3503 6708711
SGTC_832 4083-0019 164 µM -0.575887602936684 0.259690723802079 no 2495 0.282345577783224 3521 1990758
SGTC_951 1171-0579 82.7 µM -0.577316809819154 0.259179416202476 no 2496 0.281862730075251 3487 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2180 6301957 200 µM -0.580113502164657 0.25818038982531 no 2497 0.280919039504819 3478 845462
SGTC_2280 7785178 200 µM -0.580690279285184 0.257974603762821 no 2498 0.280724607172017 3427 2954328
SGTC_2224 6650123 117.647 µM -0.580787061345996 0.257940081606593 no 2499 0.280691988189006 3456 2908370
SGTC_1744 st037937 38.9 µM -0.58086955489735 0.257910658053126 no 2500 0.280664186387256 3518 1016152
SGTC_891 0929-0073 133 µM -0.581381498216569 0.257728098583395 no 2501 0.280491682126705 3492 5603632
SGTC_1401 3807-4679 7.6 µM -0.581825499549397 0.257569821624782 no 2502 0.280342113143774 3481 3291456
SGTC_2521 angolensin 13.4 µM -0.583745070868118 0.256886116947485 no 2503 0.279695919517675 3520 821428 A flavenoid.
SGTC_912 3474-0017 2.18 µM -0.585029381019932 0.256429204738697 no 2504 0.279263980587484 3530 3360550
SGTC_1101 ebselen 5.29 µM -0.585787015721719 0.256159863780228 no 2505 0.279009325147057 3557 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1183 1254-0324 198 µM -0.586450659105256 0.255924058224479 no 2506 0.278786354810837 3521 5799357
SGTC_804 1595-0054 20.9 µM -0.58656627560126 0.255882988996517 no 2507 0.278747518951857 3416 761523 Stimulates phospholipase C.
SGTC_2314 7727897 200 µM -0.58706791917638 0.255704835286985 no 2508 0.278579046176725 3426 900724
SGTC_1348 1493-0373 93.8 µM -0.589146399077391 0.254967374554368 no 2509 0.277881535080288 3459 3010129
SGTC_2026 5148700 152 µM -0.589349026353703 0.254895540411538 no 2510 0.277813581607566 3452 79838
SGTC_1642 st009582 77.7 µM -0.589906005705996 0.25469813819366 no 2511 0.277626833755129 3520 6739311
SGTC_3038 9091290 49.47 µM -0.590387684190003 0.254527488357737 no 2512 0.27746538276062 3542 25236843
SGTC_1961 st076550 68.7 µM -0.591683488732269 0.254068706118926 no 2513 0.277031277544391 3491 1579337
SGTC_1166 k206-0078 225 µM -0.591838416607414 0.254013882637386 no 2514 0.276979397685446 3504 5404595
SGTC_1377 2944-0135 198 µM -0.592153429598337 0.253902429852997 no 2515 0.276873925659945 3511 1894137
SGTC_974 1326-0144 138 µM -0.592405669724776 0.253813204851739 no 2516 0.27678948530309 3478 5411856
SGTC_34 0469-0683 81.75 µM -0.592939939692482 0.25362427169113 no 2517 0.276610673799027 3475 3690923
SGTC_2480 5767542 37.17 µM -0.595191746771754 0.252828780727497 no 2518 0.275857653235501 3497 2867358
SGTC_1303 1160-0052 261 µM -0.596253249530051 0.252454242007775 no 2519 0.275503028669701 3522 3562476
SGTC_2112 5488546 200 µM -0.599024710507947 0.251477744695331 no 2520 0.274578203258706 3456 600757
SGTC_2827 7993847 71.43 µM -0.600135954250571 0.251086770116714 no 2521 0.274207816296758 3487 2985692
SGTC_2564 betulinic acid 100 µM -0.60031524335491 0.251023720052594 no 2522 0.274148080844028 3582 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1596 piperlongumine 63 µM -0.601701670249675 0.250536442440556 no 2523 0.27368636900554 3545 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1389 3405-0187 19 µM -0.602006702992282 0.250429302050337 no 2524 0.273584837783549 3453 799890
SGTC_2727 riluzole 51.77 µM -0.602669023875587 0.250196750597847 no 2525 0.27336444614019 3513 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1776 st049249 45.9 µM -0.602890141127856 0.250119138302721 no 2526 0.273290887496087 3491 1822314
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.603570960402038 0.249880250527934 no 2527 0.273064462262983 3456 6857784
SGTC_2338 7999974 200 µM -0.604388155869286 0.249593670699727 no 2528 0.272792804211418 3570 315925
SGTC_2250 alverine citrate 130 µM -0.60570627528455 0.24913179154834 no 2529 0.272354908110942 3482 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1430 4049-0248 69.1 µM -0.605734009250011 0.249122078240091 no 2530 0.272345698285718 3562 22774488
SGTC_2110 5483698 200 µM -0.606370176512867 0.248899327745024 no 2531 0.272134483954187 3498 2848765 YHR062C RPP1
SGTC_1328 1441-0025 69.2 µM -0.607778248816487 0.248406676147674 no 2532 0.271667278665137 3487 4562601
SGTC_1121 fusaric acid 630.51 nM -0.609334547812481 0.247862768748153 no 2533 0.271151356040815 3478 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_971 1315-0384 26.7 µM -0.610853552304973 0.247332508975524 no 2534 0.270648268349455 3508 6769120
SGTC_772 k072-0172 35.3 µM -0.611014318468776 0.247276423629632 no 2535 0.270595050586012 3465 5861980
SGTC_2760 etidronate 98.04 µM -0.611314707952656 0.247171647115905 no 2536 0.270495627897173 3497 3305 A chelator and antioxidant.
SGTC_1741 st038134 10.228 µM -0.612056018697503 0.246913177925582 no 2537 0.270250347543566 3613 1272587
SGTC_2875 9039966 71.43 µM -0.612111826709162 0.246893725475706 no 2538 0.270231886633269 3517 6463691
SGTC_419 nsc-638432 893 µM -0.61310479960117 0.246547751849435 no 2539 0.269903523426633 3491 368090
SGTC_3241 9133421 49.47 µM -0.613527405415599 0.246400585505681 no 2540 0.269763833800525 3539 17018221
SGTC_3356 9151811 4.48 µM -0.617968359918157 0.244856938377153 no 2541 0.26829809771976 3498 1859254 YPR165W RHO1
SGTC_2793 7325131 81.82 µM -0.618443499405933 0.244692091728624 no 2542 0.268141515600722 3492 4176441
SGTC_2453 5731132 22.18 µM -0.62145130850124 0.243649939214795 no 2543 0.267151361032674 3594 1362040
SGTC_3321 9137793 26.8275 µM -0.621887669275283 0.243498947266598 no 2544 0.267007866870908 3554 4904192
SGTC_1243 0416-0003 5.65 µM -0.621993235005902 0.243462426428251 no 2545 0.266973158173495 3501 2141977
SGTC_3159 9100096 49.47 µM -0.622754193951987 0.243199257554092 no 2546 0.266723031785809 3526 25236875
SGTC_3288 9119690 36.221 µM -0.623121378990181 0.243072325873911 no 2547 0.266602380839833 3507 17595618 YKL019W RAM2
SGTC_602 3130-1533 38.1 µM -0.623458209000194 0.242955919095677 no 2548 0.266491728328545 3579 720941
SGTC_660 4031-1742 102 µM -0.623957877597553 0.242783291676986 no 2549 0.266327624279477 3498 6738706
SGTC_1153 4055-0057 267 µM -0.624848567222036 0.2424757375285 no 2550 0.266035225727344 3517 882706
SGTC_923 1900-2434 73.3 µM -0.625363651756003 0.242297975762714 no 2551 0.265866206299357 3545 5910570
SGTC_555 4296-0685 37 µM -0.626433764199407 0.241928893188744 no 2552 0.265515234509072 3532 2908540 YHR072W ERG7
SGTC_1052 3253-3998 198 µM -0.627732474357754 0.241481377074355 no 2553 0.265089603978878 3542 5450317
SGTC_3058 9093861 49.47 µM -0.628403699180167 0.241250259386951 no 2554 0.264869757202822 3602 17217477
SGTC_792 4534-1957 155 µM -0.629322470358401 0.240934100952705 no 2555 0.264568981697423 3506 1717904
SGTC_1899 st063254 59.6 µM -0.62992392233503 0.240727257372137 no 2556 0.264372180225105 3509 3093813
SGTC_1906 st060206 94.7 µM -0.630810043067483 0.240422690355906 no 2557 0.264082367949221 3557 5133468
SGTC_2108 5365811 200 µM -0.631525221606034 0.240177030718227 no 2558 0.263848581665708 3572 780283
SGTC_2306 7482397 179.52 µM -0.63328655936325 0.239572605302144 no 2559 0.263273264389858 3572 891448
SGTC_2726 cimetidine 79.27 µM -0.634023745819811 0.239319877122565 no 2560 0.263032662686965 3558 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_277 nystatin 15.5 µM -0.6358972838591 0.23867823168512 no 2561 0.262421686567724 3544 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_476 mead acid 10 µM -0.636132541698105 0.238597727642938 no 2562 0.262345018439742 3592 5312531 An omega 9 fatty acid.
SGTC_1925 st057770 10.1 µM -0.636221561944308 0.238567269241191 no 2563 0.262316010642181 3466 5989122
SGTC_491 tetrandrine 80.3 µM -0.636629463929275 0.238427732228105 no 2564 0.262183114271257 3572 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2844 9010103 25.97 µM -0.63740030899469 0.238164160020442 no 2565 0.261932063581517 3579 2480525
SGTC_3146 9095609 49.47 µM -0.63762688792339 0.238086717095169 no 2566 0.261858294254162 3567 17173999
SGTC_1487 3970-0795 2.82 µM -0.637879980304064 0.238000228397335 no 2567 0.261775905305731 3599 3765103
SGTC_756 0508-1999 28.3 µM -0.638243659219159 0.237875979368949 no 2568 0.261657540503763 3493 6753853
SGTC_2556 citropten 84.59 µM -0.639585224705884 0.237417948188758 no 2569 0.261221145382207 3528 2775 A potential DNA crosslinker.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.639711257871229 0.23737494341393 no 2570 0.261180167534557 3555 2333 A French combination drug.
SGTC_1253 0550-0034 176 µM -0.639792646311438 0.23734717449246 no 2571 0.261153707024441 3553 5969915
SGTC_3094 9117742 49.47 µM -0.640156771764294 0.237222960376505 no 2572 0.261035341664877 3540 17149698
SGTC_447 ml7 120 µM -0.641822044926501 0.236655341074477 no 2573 0.260494367167333 3600 4216 Selective myosin light chain kinase inhibitor.
SGTC_678 1218-2179 85.9 µM -0.641971557270132 0.236604415387124 no 2574 0.260445825397055 3559 6820081 YOR116C RPO31
SGTC_3056 9094900 49.47 µM -0.642293773513662 0.236494685193205 no 2575 0.260341228156727 3524 25236784
SGTC_3341 9147222 25.867 µM -0.643112675799555 0.236215935492227 no 2576 0.260075495035735 3567 1939759
SGTC_817 1391-0715 46 µM -0.643317717473788 0.236146168803985 no 2577 0.260008981077854 3517 1353946
SGTC_1826 st055655 41.6 µM -0.643350975368286 0.236134853671183 no 2578 0.259998193296974 3567 676168
SGTC_2813 7971799 71.43 µM -0.64344399080186 0.236103209177165 no 2579 0.25996802333666 3592 2234054
SGTC_733 4069-0007 56.1 µM -0.643947446677637 0.235931970555729 no 2580 0.259804756573843 3624 5717425 YNL287W SEC21
SGTC_3145 9085516 49.47 µM -0.644159196170965 0.235859969422769 no 2581 0.259736103695026 3571 25236195
SGTC_1130 3454-2858 15.9 µM -0.644253957945399 0.23582775152149 no 2582 0.259705383307767 3527 715628 YIL048W NEO1
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.646085590999558 0.235205494489247 no 2583 0.259111963199703 3669 688664
SGTC_2102 5377816 72.7585 µM -0.646671803815136 0.235006533272629 no 2584 0.258922187729347 3616 1379702
SGTC_2294 7971431 200 µM -0.646865061264326 0.234940961886703 no 2585 0.258859639996122 3539 5741572
SGTC_1266 0828-0227 32.9 µM -0.646918773782009 0.234922739265868 no 2586 0.258842257339408 3540 3913820
SGTC_1503 4585-0012 61.3 µM -0.647064278510789 0.234873378951926 no 2587 0.258795171559855 3606 2922052
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.647622974783374 0.234683902824626 no 2588 0.258614416914958 3595 2724 A muscle relaxant with antifungal properties.
SGTC_2353 9059630 146.67 µM -0.649261753523991 0.234128615631857 no 2589 0.258084601207028 3598 4779114
SGTC_1288 0973-0013 65.5 µM -0.649910027918994 0.233909153982982 no 2590 0.257875170150846 3617 4315430
SGTC_841 0251-0215 91.2 µM -0.650019826528196 0.233871994926897 no 2591 0.257839707426531 3600 3888614
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.650576927718163 0.233683506025248 no 2592 0.257659814042815 3569 2346 DNA damaging agent; causes G2/M arrest.
SGTC_698 k064-0052 127 µM -0.651251708799752 0.233455314285335 no 2593 0.257442007980224 3648 5088751
SGTC_3324 9138759 60.749 µM -0.651263248361959 0.233451413009388 no 2594 0.257438284068559 3597 45595710
SGTC_219 mitoxanthrone 164.414 µM -0.651677259319203 0.233311468801944 no 2595 0.257304697842542 3567 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_878 0828-0289 13.7 µM -0.652745925524706 0.232950452932019 no 2596 0.256960044857018 3609 745350 YLR208W SEC13
SGTC_397 arbidol 50 µM -0.652829689012259 0.232922169143955 no 2597 0.256933040648926 3628 131410 A RNA synthesis inhibitor.
SGTC_724 3910-0327 137 µM -0.653880479589295 0.232567518683964 no 2598 0.25659440555867 3601 2885483
SGTC_380 3970-0968 6 µM -0.656351626086843 0.231734670844255 no 2599 0.255798953729978 3569 2891601
SGTC_1520 flindersine 88 µM -0.657057560463731 0.231497056068435 no 2600 0.255571952990257 3682 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2622 2-methoxyxanthone 59.94 µM -0.657644958541149 0.23129944373224 no 2601 0.255383149098774 3616 71034 A hepatoprotective.
SGTC_448 monastrol 171 µM -0.657703574413819 0.231279729357333 no 2602 0.255364312546145 3561 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1260 0700-1617 7.75 µM -0.659082741592023 0.230816142316629 no 2603 0.254921318757618 3606 2853078
SGTC_1550 gossypolone 36.6 µM -0.660077573617743 0.230482066400655 no 2604 0.25460202474247 3625 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2234 tolnaftate 200 µM -0.661870902014169 0.229880529609523 no 2605 0.254026980758708 3592 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1050 3232-1156 69.3 µM -0.663557687427523 0.229315533584241 no 2606 0.253486723108163 3579 700529
SGTC_2070 5230947 200 µM -0.663659914700969 0.229281317157621 no 2607 0.253454000322263 3681 2835538
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.664930864467815 0.228856157454259 no 2608 0.253047356775694 3597 803109
SGTC_2702 st077768 96.8 µM -0.665578688621935 0.228639616879784 no 2609 0.252840215968373 3557 6484119
SGTC_827 3253-0474 693 µM -0.665976269012498 0.228506779346571 no 2610 0.252713134445675 3621 5402065
SGTC_1957 st077035 62.4 µM -0.666113251084471 0.228461021639175 no 2611 0.252669357658185 3682 705593
SGTC_777 1315-0167 517 µM -0.666543586813104 0.228317305108388 no 2612 0.252531856773677 3585 4221767
SGTC_1953 st076800 12.1 µM -0.667461945831318 0.228010776478619 no 2613 0.252238554565792 3595 297591
SGTC_642 0335-0876 158 µM -0.668633469382571 0.22762008313505 no 2614 0.251864658475054 3639 6812350
SGTC_1563 conessine 56.1 µM -0.668748831341554 0.227581631278594 no 2615 0.251827856106939 3703 441082 An anti-amoebic, histamine inhibitor.
SGTC_2628 lathosterol 100 µM -0.668969701547782 0.227508022160334 no 2616 0.251757402789016 3679 6710616
SGTC_2463 5473429 200 µM -0.669524813016971 0.227323080113347 no 2617 0.251580378941897 3581 5399405
SGTC_129 0088-0017 176.636 µM -0.670432571526672 0.227020832072184 no 2618 0.251291038466983 3562 182446
SGTC_640 3381-0960 37.1 µM -0.670583220552299 0.226970693777952 no 2619 0.251243037370948 3666 1745025
SGTC_1161 k007-0610 110 µM -0.670584034365066 0.226970422945606 no 2620 0.25124277808005 3669 5843850
SGTC_3308 9128332 17.569 µM -0.671553609023429 0.226647883392061 no 2621 0.250933960038134 3644 17332805 YDL196W YDL196W
SGTC_1285 0929-0069 65.5 µM -0.67217894406325 0.226439996192849 no 2622 0.250734891957313 3629 1206237
SGTC_1863 st057641 20.1 µM -0.672364306766053 0.226378394668734 no 2623 0.250675899985821 3649 3921635
SGTC_1424 4048-1941 275 µM -0.672756071561291 0.226248230753299 no 2624 0.250551244414233 3683 X1424
SGTC_2528 xanthyletin 44.79 µM -0.67320868134913 0.226097903736867 no 2625 0.250407269485069 3668 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.673222089586679 0.226093451268853 no 2626 0.25040300500081 3644 442882
SGTC_1108 betulinic acid 729.144 nM -0.674391821304911 0.225705209719978 no 2627 0.250031120535129 3647 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1959 st077091 55.8 µM -0.674557244548337 0.225650335128651 no 2628 0.249978552364279 3647 821356 YKL052C ASK1
SGTC_1287 0971-0001 34.6 µM -0.674634864368832 0.22562458949959 no 2629 0.249953888372392 3640 4665869
SGTC_596 1155-0152 116 µM -0.675020649091475 0.225496653671419 no 2630 0.249831322978735 3639 280313
SGTC_2251 lansoprazole 556 µM -0.675482936445227 0.225343401761209 no 2631 0.249684494419026 3552 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1816 st051957 91.6 µM -0.675755725544532 0.225252997694696 no 2632 0.249597874509481 3639 674121
SGTC_675 1309-0189 238 µM -0.676660198338696 0.22495339658912 no 2633 0.249310787577017 3616 4246530
SGTC_1331 1472-0049 76.2 µM -0.677256046129751 0.224756149106393 no 2634 0.249121756664597 3621 24051409
SGTC_896 0964-0007 44.5 µM -0.677732912631646 0.224598359477082 no 2635 0.248970527148292 3623 6756758
SGTC_1956 st077085 54 µM -0.677945173997172 0.224528144854249 no 2636 0.248903228042273 3647 24208685
SGTC_146 3448-8650 53.125 µM -0.67845364569834 0.22435999652001 no 2637 0.248742052547082 3646 2891488 YIL048W NEO1
SGTC_2512 diallyl trisulfide 49.23 µM -0.678751705767479 0.224261463204634 no 2638 0.248647599230357 3642 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_963 1269-2853 151 µM -0.678874046312067 0.224221026726877 no 2639 0.248608835830013 3630 3668223
SGTC_544 k015-0020 52.4 µM -0.679146477109178 0.224130996704734 no 2640 0.248522528146763 3641 3008304
SGTC_781 4335-2806 94.4 µM -0.681051250626215 0.223502101375257 no 2641 0.247919530951733 3729 845254
SGTC_486 niguldipine 82 µM -0.681475734971911 0.223362087111533 no 2642 0.247785257740035 3649 1236 A calcium channel blocker.
SGTC_1071 trifluoperazine 6.31 µM -0.682400126571762 0.2230573534322 no 2643 0.24749298787574 3704 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1762 st045503 25.4615 µM -0.68262830333112 0.222982169440614 no 2644 0.247420872359342 3668 4645554
SGTC_3257 9139206 32.98 µM -0.683451110766702 0.222711175193378 no 2645 0.247160916452982 3612 4910041
SGTC_2516 gossypol 71.55 µM -0.684261330675473 0.222444510207051 no 2646 0.246905080228905 3662 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2852 9023854 51.95 µM -0.684950255539826 0.222217909974269 no 2647 0.24668765584604 3710 19798528
SGTC_1714 st033236 13.627 µM -0.685549446762649 0.222020931958754 no 2648 0.2464986347622 3690 2916566
SGTC_2242 6630449 61.2675 µM -0.685828510159625 0.221929226742746 no 2649 0.246410627814474 3654 691249 YDR170C SEC7
SGTC_668 1682-0499 62.6 µM -0.686139283198811 0.221827126633467 no 2650 0.24631264056335 3687 682214
SGTC_750 4073-0104 132 µM -0.686160479841257 0.221820163752362 no 2651 0.246305957988092 3523 22330957
SGTC_557 1315-0110 16.2 µM -0.686334658516369 0.221762952559926 no 2652 0.24625104909932 3659 6833801
SGTC_3243 9134147 49.47 µM -0.69124847395603 0.220152424650764 no 2653 0.24470470307764 3712 24282180
SGTC_1583 clindamycin 39.6 µM -0.691447709826937 0.220087265905014 no 2654 0.244642115314773 3594 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_950 1165-0508 94.1 µM -0.691588485162516 0.220041232952876 no 2655 0.244597897485644 3649 6148369
SGTC_2354 9060492 162 µM -0.69209715351354 0.219874946552086 no 2656 0.244438159568826 3680 6471895
SGTC_1237 0330-0133 46.1 µM -0.692137471280695 0.219861769544127 no 2657 0.244425500922017 3618 X1237 YHR072W ERG7
SGTC_2178 5812956 200 µM -0.692364226785971 0.219787667754993 no 2658 0.244354312640856 3649 5403383
SGTC_2912 7964298 10.93 µM -0.693530593485205 0.21940673554793 no 2659 0.243988316718758 3703 2975850
SGTC_2734 clemastine 41.6 µM -0.694528676262888 0.219081065825045 no 2660 0.243675361817512 3649 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_389 tpck 16.7 µM -0.695583119789176 0.218737308004517 no 2661 0.243344970244577 3659 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1912 st060209 90.8 µM -0.696286632385148 0.218508129488795 no 2662 0.243124671498611 3662 688787
SGTC_247 mechlorethamine 29.705 µM -0.696396383785593 0.218472388993037 no 2663 0.243090313545249 3602 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2059 5238311 157 µM -0.697096582251467 0.218244448934407 no 2664 0.242871176471177 3669 703021
SGTC_2258 7960471 200 µM -0.697218641882442 0.21820472811699 no 2665 0.242832987116544 3616 2974708
SGTC_3175 9106517 49.47 µM -0.698137869945316 0.217905725474574 no 2666 0.242545488447712 3673 41468073
SGTC_1570 verbenone 133 µM -0.69904557516324 0.217610702916474 no 2667 0.242261774663523 3685 29025 A natural terpanoid with antifungal properties.
SGTC_2856 9022925 19.48 µM -0.699389521640838 0.217498973600408 no 2668 0.242154317216112 3662 4944862
SGTC_1280 0880-0253 10.1 µM -0.700678571541762 0.217080526827216 no 2669 0.241751815921459 3656 6836607
SGTC_3223 9129970 49.47 µM -0.704637262566574 0.215798382287806 no 2670 0.240518001553088 3722 17248386
SGTC_3104 9120930 49.47 µM -0.704708531159622 0.215775340041948 no 2671 0.240495820570955 3685 17014836
SGTC_1360 1598-0022 39.8 µM -0.704826938375566 0.215737060298419 no 2672 0.240458971059806 3722 761525
SGTC_2763 lisinopril 49.32 µM -0.705568817595209 0.215497308569016 no 2673 0.240228160823545 3646 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1625 st003711 30.1 µM -0.706273799704889 0.21526962407725 no 2674 0.240008941778517 3718 24207034 YER133W GLC7
SGTC_1190 1486-1332 13 µM -0.707318535280279 0.214932468000646 no 2675 0.239684274750708 3680 4150046
SGTC_2268 7933382 153.85 µM -0.710376935607035 0.213947228800114 no 2676 0.238735210968672 3718 935025 YOR257W CDC31
SGTC_81 0411-0046 9.971 µM -0.710585589365877 0.213880108602787 no 2677 0.238670537834675 3590 12925265
SGTC_549 1661-1316 519 µM -0.711375866908409 0.213626001580134 no 2678 0.238425674837371 3716 2857282
SGTC_2718 lomofungin 53.02 µM -0.71142342568253 0.213610715073844 no 2679 0.238410943411379 3700 5351222 A RNA synthesis inhibitor.
SGTC_2305 7443522 69.23 µM -0.711915447436909 0.21345260514002 no 2680 0.238258567937145 3656 5415886
SGTC_1720 st037298 9.481 µM -0.712668882601192 0.213210622919588 no 2681 0.238025338107842 3704 597396
SGTC_2601 securinine 100 µM -0.714140182329221 0.212738544270359 no 2682 0.237570250535605 3667 442872 A GABA receptor antagonist.
SGTC_132 0417-1715 25.805 µM -0.715599028517332 0.21227106452112 no 2683 0.237119486830288 3711 6769098
SGTC_1554 st069299 38.7 µM -0.716443931146921 0.212000594608643 no 2684 0.236858638412989 3677 24207999
SGTC_233 rapamycin 362 pM -0.716605444108825 0.211948914096883 no 2685 0.236808792173792 3703 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1663 st014140 55.4 µM -0.717846338509577 0.211552101691245 no 2686 0.236426018978039 3760 4207120
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.718542289552853 0.211329741427574 no 2687 0.236211491198482 3726 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3155 9099265 49.47 µM -0.719043261300864 0.211169762923246 no 2688 0.236057132416938 3663 25236499
SGTC_260 nsc-65238 3.989 µM -0.721205399241499 0.21048012818757 no 2689 0.235391575176049 3644 3246252
SGTC_3294 9122953 26.2835 µM -0.722075468673215 0.210202984591967 no 2690 0.235124039745357 3723 16459826
SGTC_591 4299-0174 154 µM -0.722414832151952 0.210094945123127 no 2691 0.235019735279606 3694 5509088
SGTC_2881 9058953 51.95 µM -0.722538194694326 0.210055679615018 no 2692 0.234981825738325 3693 17122249
SGTC_1838 st055369 84.5 µM -0.722655057212391 0.210018487000158 no 2693 0.234945916783256 3691 676036
SGTC_1213 1315-0166 115 µM -0.725084850672236 0.209246058969293 no 2694 0.234199988820134 3741 768401
SGTC_2698 st077697 67.5 µM -0.726373916553372 0.208836946518779 no 2695 0.233804788420613 3683 3154499
SGTC_2750 bromebric acid 70.15 µM -0.726887610308941 0.208674046305985 no 2696 0.233647403801926 3761 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2566 crystal violet carbinol 226 nM -0.729562519938714 0.207827002417702 no 2697 0.232828819547163 3691 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3352 9151559 45.5865 µM -0.730188452667931 0.207629086494648 no 2698 0.232637499962018 3714 17159339
SGTC_626 0214-0009 33 µM -0.731568152379467 0.207193227745657 no 2699 0.232216096364905 3762 3437874
SGTC_3273 9137859 49.47 µM -0.731922114513568 0.207081495416357 no 2700 0.232108053727953 3790 2377234
SGTC_2261 9010538 184.68 µM -0.73361107855769 0.206548845014053 no 2701 0.231592903482131 3669 6457250
SGTC_1090 efavirenz 20.7 µM -0.733659599852007 0.206533554803127 no 2702 0.231578113444502 3790 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_571 k831-0106 44.2 µM -0.734228877277911 0.206354212066291 no 2703 0.231404628248397 3688 4783639
SGTC_736 0958-0254 92.6 µM -0.734533612139592 0.206258247627511 no 2704 0.231311791212741 3785 6812352
SGTC_2450 5739737 12.93 µM -0.734865390206329 0.206153797062622 no 2705 0.231210739129672 3745 2262825
SGTC_3023 9089636 49.47 µM -0.735531503178207 0.205944185696129 no 2706 0.2310079305932 3808 17249241
SGTC_3005 9076496 71.4286 µM -0.736457225455749 0.205653090907502 no 2707 0.230726244904099 3746 21368410
SGTC_2447 5741742 33.78 µM -0.736753711280106 0.205559912145227 no 2708 0.2306360685661 3775 1776504
SGTC_913 3487-1245 167 µM -0.737273146353214 0.205396725931858 no 2709 0.230478129565287 3703 4016153
SGTC_58 0957-0393 9 µM -0.737847154181969 0.205216484608455 no 2710 0.230303667555659 3666 6997992
SGTC_322 k048-0136 19.3 µM -0.737993061006021 0.205170684121587 no 2711 0.230259332900694 3758 6823282
SGTC_3002 9075603 71.4286 µM -0.73823718574593 0.205094066390207 no 2712 0.230185164824191 3718 20105405
SGTC_1692 fluoroquinolonic acid 71 µM -0.738607757814307 0.204977796091192 no 2713 0.2300726060488 3757 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1650 st011916 45.8 µM -0.741775138640964 0.203985601864242 no 2714 0.229111792977291 3702 242528
SGTC_188 3229-0966 278.469 µM -0.742298289290927 0.203821998704868 no 2715 0.228953314040835 3808 5722370
SGTC_3217 9129673 49.47 µM -0.743037051757465 0.203591101232631 no 2716 0.228729624241896 3731 17248312
SGTC_1623 st003709 20.3 µM -0.743354930760304 0.203491797348123 no 2717 0.228633411467353 3733 16192618
SGTC_845 0330-0138 4.51 µM -0.743874312840763 0.203329607047059 no 2718 0.228476258458873 3690 9039800
SGTC_209 4077-0173 175.592 µM -0.744344226425536 0.203182931034898 no 2719 0.228334125780554 3681 15993494
SGTC_643 k048-0106 28.4 µM -0.744950304108806 0.202993846867824 no 2720 0.228150881550558 3771 6763920
SGTC_536 3852-0578 10.6 µM -0.747181209680178 0.202298754572107 no 2721 0.22747709242903 3752 2869208
SGTC_2782 7736369 71.43 µM -0.747220361938666 0.202286568469362 no 2722 0.227465277486241 3808 2950836 YOL077C BRX1
SGTC_265 mycophenolic acid 32.932 µM -0.747949392842671 0.202059738518058 no 2723 0.227245341615767 3833 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_372 0155-0182 15.9 µM -0.748333157412773 0.201940395568818 no 2724 0.227129614722575 3723 771486
SGTC_937 3122-0005 46.7 µM -0.749300816839384 0.201639660626924 no 2725 0.22683795779589 3772 759535
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.749328841488039 0.201630954959458 no 2726 0.226829514189268 3783 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.751213481948112 0.201046020984424 no 2727 0.226262093866901 3804 279621
SGTC_191 3914-0123 66.505 µM -0.751976655526086 0.200809445395067 no 2728 0.226032548799568 3704 3144412
SGTC_1150 3909-7983 10.9 µM -0.752050805987127 0.200786468459113 no 2729 0.226010253064061 3749 23965914
SGTC_2836 9010338 19.48 µM -0.75251569835866 0.200642448644082 no 2730 0.225870496464236 3727 2994051
SGTC_661 1304-0007 33.6 µM -0.752719594198689 0.200579302968213 no 2731 0.225809216430211 3761 3117130
SGTC_1459 k035-0031 35.7 µM -0.752887335798803 0.200527363054628 no 2732 0.225758809451167 3626 3877128 YMR208W ERG12
SGTC_2842 9000675 19.48 µM -0.754090082557877 0.20015517828807 no 2733 0.225397566036744 3760 2989072
SGTC_714 4296-0578 26.1 µM -0.755129359324501 0.199833913216363 no 2734 0.225085684362873 3796 1589775
SGTC_873 0591-4978 488 µM -0.75531251335124 0.199777328129765 no 2735 0.225030746124815 3796 3305145
SGTC_2943 9068529 45.32 µM -0.755926299364956 0.199587770396966 no 2736 0.224846692441543 3774 3270634
SGTC_2326 6164455 177.58 µM -0.75626166143043 0.199484245071737 no 2737 0.224746164757585 3765 2888790
SGTC_1428 4049-0204 61.7 µM -0.758770078568338 0.198710929313649 no 2738 0.223995053775991 3805 X1428
SGTC_294 k038-0071 157 µM -0.759698707193302 0.198425103019332 no 2739 0.223717350852726 3782 24152826
SGTC_2376 9072922 81.32 µM -0.759900675017162 0.198362971398978 no 2740 0.223656979054588 3786 17087968
SGTC_1250 0485-0349 40.2 µM -0.759948039136969 0.198348402413747 no 2741 0.223642822412372 3779 6842794 YDL195W SEC31
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.760578313870421 0.198154594281822 no 2742 0.223454488367565 3767 641818 YHR062C RPP1
SGTC_886 0866-0150 153 µM -0.762074556550259 0.197694960954063 no 2743 0.223007753705306 3783 271463
SGTC_1461 k072-0203 53.8 µM -0.762297253799393 0.197626605337631 no 2744 0.222941306281815 3707 5418714
SGTC_1696 st025591 34.7925 µM -0.762532858907769 0.197554303283571 no 2745 0.222871019747061 3765 2787147
SGTC_1384 3089-0840 101 µM -0.762958964982765 0.197423581270162 no 2746 0.222743934370352 3736 1069836
SGTC_856 0433-0016 11.3 µM -0.763444290924489 0.197274755354755 no 2747 0.222599237094071 3833 3911780
SGTC_1827 berberine 7.24 µM -0.763564003469222 0.197238055763842 no 2748 0.222563553694462 3718 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2452 5863136 48.41 µM -0.76408699353524 0.19707777413016 no 2749 0.222407701320941 3744 2184096
SGTC_2343 7990716 14.84 µM -0.764367267331265 0.196991910604712 no 2750 0.222324204640128 3764 6456862
SGTC_2511 berberine 10.47 µM -0.765188468543554 0.196740461186039 no 2751 0.22207966265246 3770 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_404 fumagillin 50 µM -0.765398499043434 0.196676181688304 no 2752 0.222017143236394 3766 12015870 A methionine aminopeptidase binder.
SGTC_460 trequinsin 123 µM -0.765912152806059 0.196519032385063 no 2753 0.22186428715288 3821 5537 A vasodilator.
SGTC_2135 5326629 150.42 µM -0.766110226754635 0.196458453175132 no 2754 0.221805359213363 3761 5020077
SGTC_4 0960-0234 25.671 µM -0.766659125996815 0.196290636217171 no 2755 0.221642105809189 3759 6821112
SGTC_13 0199-0087 65 µM -0.768573364849478 0.195706069374476 no 2756 0.221073311194502 3818 4589825
SGTC_1477 0139-0234 16 µM -0.769484819916244 0.195428102625785 no 2757 0.220802776357572 3794 620880
SGTC_1952 st077036 64.1 µM -0.769752965033032 0.195346371996692 no 2758 0.220723222586377 3774 2937007
SGTC_618 k072-0232 33.2 µM -0.771088948358005 0.194939473843274 no 2759 0.220327105403426 3811 5872756 YGL099W LSG1
SGTC_2712 st079126 47.7 µM -0.771382605009117 0.194850104477934 no 2760 0.220240091285089 3781 3152970
SGTC_1851 st056236 18.9 µM -0.774304280648113 0.193962300490231 no 2761 0.219375436435364 3764 5393171
SGTC_444 curcumin 90.4 µM -0.774840976400933 0.193799484179146 no 2762 0.219216816428298 3752 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_771 0250-0039 27.3 µM -0.774914089751697 0.193777310378706 no 2763 0.219195212938677 3767 3005115
SGTC_936 3005-4620 401 µM -0.775421787717181 0.193623378517124 no 2764 0.219045232404951 3797 777207
SGTC_1572 epiandrosterone 68.9 µM -0.776656557995104 0.19324931276895 no 2765 0.21868071173242 3721 441302 A steroid.
SGTC_957 1187-1561 14.1 µM -0.777951819932273 0.192857395824796 no 2766 0.218298708618651 3768 1538454
SGTC_2193 5925765 200 µM -0.778256643379687 0.192765233772972 no 2767 0.218208864952633 3780 877370
SGTC_1613 st002381 52.1 µM -0.780255125257784 0.192161668182695 no 2768 0.217620360410296 3772 551167
SGTC_1660 st012960 28.1 µM -0.780596924634476 0.192058556554905 no 2769 0.217519800565412 3801 24207266
SGTC_2146 5545642 200 µM -0.780762406649489 0.192008647272707 no 2770 0.217471124199416 3787 825326
SGTC_1683 st010134 710 nM -0.781193072963721 0.191878795768461 no 2771 0.217344473623205 3817 3818134
SGTC_1897 st060201 15 µM -0.782041991922384 0.191622993112333 no 2772 0.217094947852737 3846 611878
SGTC_854 0422-0053 192 µM -0.783300334047126 0.191244204476832 no 2773 0.216725383559426 3845 3596728
SGTC_2592 piperlongumine 83.33 µM -0.783701168381487 0.191123640990809 no 2774 0.216607738401079 3830 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1058 3448-5425 97.3 µM -0.784182307533558 0.190978984874856 no 2775 0.216466572519422 3705 7279705
SGTC_1933 st074711 15.9 µM -0.784617704091373 0.190848139323124 no 2776 0.216338873380229 3799 17250958
SGTC_3221 9128209 49.47 µM -0.786481239839962 0.190288730545475 no 2777 0.215792802749742 3849 16460723
SGTC_1530 rhein 70.4 µM -0.790198470438447 0.189175879533168 no 2778 0.21470593458899 3859 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_505 gw-5074 63.9 µM -0.790201486684302 0.189174978170753 no 2779 0.214705053972951 3860 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2857 9024691 58.44 µM -0.790570334434292 0.189064773173227 no 2780 0.214597381875058 3897 16478292
SGTC_1964 st076914 61 µM -0.792175811224883 0.188585546709135 no 2781 0.214129085294804 3860 24208661
SGTC_3306 9127676 59.7925 µM -0.793217817204537 0.188274914500095 no 2782 0.213825464271064 3828 41905287
SGTC_1821 st053465 65.6 µM -0.793501683854135 0.18819034581005 no 2783 0.213742794318713 3823 675086
SGTC_323 4013-0906 34.3 µM -0.794988424081161 0.187747803668989 no 2784 0.213310117935755 3851 2910086
SGTC_1316 1272-0050 65.9 µM -0.796184322272957 0.187392300259773 no 2785 0.212962454312212 3800 7340392
SGTC_1242 0402-0103 60.1 µM -0.798648328068578 0.186661140799418 no 2786 0.212247178189592 3777 432868
SGTC_821 1114-0266 29.2 µM -0.799154168126189 0.186511258596643 no 2787 0.212100511823558 3845 3123235
SGTC_1330 1469-0054 61.8 µM -0.801081990623784 0.185940721570228 no 2788 0.211542090718695 3858 7102664
SGTC_2966 9084041 48.03 µM -0.803523132773738 0.185219822791124 no 2789 0.210836215850634 3784 17741380
SGTC_830 4076-0286 57.8 µM -0.803782863552252 0.18514322344873 no 2790 0.210761194104319 3894 6866659
SGTC_1934 st074720 32.6 µM -0.805481138357193 0.184642856315051 no 2791 0.210271043210588 3785 17250992
SGTC_2332 7982454 138.89 µM -0.80551759890012 0.184632123078278 no 2792 0.210260527425074 3798 2981748
SGTC_2713 st079149 53.4 µM -0.807010605596681 0.184192945745782 no 2793 0.209830186468894 3879 3103253
SGTC_1127 asiatic acid 681.4 nM -0.811436318388938 0.182894918950389 no 2794 0.208557574791397 3827 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2118 5526350 200 µM -0.813043142819073 0.182425066033754 no 2795 0.208096661541685 3906 743594
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.813128117963992 0.18240023938971 no 2796 0.208072303400192 3905 5379071
SGTC_1318 1280-3875 124 µM -0.813368005934438 0.182330164248795 no 2797 0.208003548549787 3860 373245
SGTC_1422 4031-0024 15.5 µM -0.81357807214763 0.182268814340666 no 2798 0.207943351998957 3786 782427
SGTC_170 4197-0004 226 µM -0.813856243627787 0.182187594120872 no 2799 0.207863655040888 3889 218692
SGTC_3075 9116269 49.47 µM -0.814473894110497 0.182007334067883 no 2800 0.207686760840266 3859 17015205 YNL244C SUI1
SGTC_1608 st001473 40.5 µM -0.814692722139077 0.181943496310552 no 2801 0.207624110153269 3823 7292267
SGTC_2122 5258151 111.688 µM -0.815645041072845 0.181665843505498 no 2802 0.207351590347143 3856 2173356
SGTC_2558 carylophyllene oxide 100 µM -0.816648819970218 0.181373474486238 no 2803 0.207064573590108 3945 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2316 5844804 197.44 µM -0.816853920838224 0.181313771363422 no 2804 0.207005956753885 3916 776813
SGTC_2256 7954252 200 µM -0.817779707223241 0.181044435967003 no 2805 0.20674149369172 3878 2972920
SGTC_3184 9108758 49.47 µM -0.818081235542272 0.180956767662976 no 2806 0.206655401365902 3857 902885
SGTC_3043 9092303 49.47 µM -0.821283999873756 0.180027217742006 no 2807 0.205742259640373 3867 25236084
SGTC_136 0097-0015 404.482 µM -0.821970094013653 0.179828480751042 no 2808 0.205546958865248 3863 4861337
SGTC_3222 9128301 49.47 µM -0.822115872464091 0.179786271693657 no 2809 0.205505476344994 3885 4911358
SGTC_3 0833-0587 95.581 µM -0.822261710123722 0.179744051720754 no 2810 0.205463981950529 3797 5382644
SGTC_2170 morpholine 200 µM -0.823188889945737 0.179475779055856 no 2811 0.205200292911859 3899 121171 Reacts with secondary amines.
SGTC_300 r073-0011 5.04 µM -0.824353544758145 0.179139151603686 no 2812 0.204869351299174 3863 2735780
SGTC_706 4262-0057 46.9 µM -0.824750523170892 0.179024501274497 no 2813 0.204756620762517 3854 883298
SGTC_3295 9122362 53.5725 µM -0.825022778376031 0.178945898634365 no 2814 0.204679329388909 3924 4730473
SGTC_1107 amlodipine 47 µM -0.8255603047344 0.178790773495811 no 2815 0.204526780336984 3680 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1376 2910-0861 41.3 µM -0.825907579019937 0.178690598373335 no 2816 0.204428260481167 3829 1112859
SGTC_529 4076-0302 30.3 µM -0.825938122732211 0.178681789391622 no 2817 0.204419596745188 3831 5816522
SGTC_2810 7959871 45.46 µM -0.826037099118552 0.178653245913106 no 2818 0.20439152355599 3863 2974535
SGTC_3000 9075062 71.4286 µM -0.827155885200533 0.178330802506867 no 2819 0.204074356035223 3843 17057871
SGTC_2895 9054447 58.44 µM -0.82727703495468 0.178295908163181 no 2820 0.204040028584435 3899 2697450
SGTC_2892 9047358 58.44 µM -0.827824523435566 0.17813827061612 no 2821 0.203884942128944 3862 6466771
SGTC_677 0929-0063 136 µM -0.828989377096407 0.177803168449804 no 2822 0.203555209155168 3845 1539583
SGTC_1629 st005085 44.9 µM -0.829735738224893 0.177588666316593 no 2823 0.203344105366272 3858 24207091
SGTC_946 3434-1334 87.4 µM -0.833058044111111 0.176635827348391 no 2824 0.202405997166116 3870 4047976
SGTC_920 mycophenolic acid 780.421 nM -0.833222946895272 0.176588617511495 no 2825 0.202359501642707 3917 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3057 9095946 49.47 µM -0.833562942610168 0.176491305701116 no 2826 0.202263657574686 3893 24540043
SGTC_2706 st078239 82.5 µM -0.834532345134809 0.176214034610204 no 2827 0.201990534191405 3860 15434492
SGTC_2607 solasodine 47.35 µM -0.834533430652277 0.176213724282215 no 2828 0.201990228477114 3900 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1666 st014829 29 µM -0.835113570849939 0.176047923156368 no 2829 0.201826883217424 3885 3858230
SGTC_1387 3342-1166 1.8 µM -0.836811799301699 0.17556314603185 no 2830 0.201349181973356 3873 3418228
SGTC_2029 5175081 200 µM -0.836992523068429 0.175511606388623 no 2831 0.201298385416821 3876 1380876
SGTC_2822 7994718 71.43 µM -0.837432646393207 0.175386130094428 no 2832 0.201174710809801 3863 1018011
SGTC_2284 7945075 39.21 µM -0.839872010034666 0.174691714880124 no 2833 0.200490076383874 3946 1245402
SGTC_3267 9137951 49.47 µM -0.841739119008229 0.174161384801228 no 2834 0.199966998204379 3907 16643986
SGTC_2134 5324836 1.464 µM -0.842219687927957 0.174025050674458 no 2835 0.19983249776611 3863 699272
SGTC_1709 st033179 39.1045 µM -0.843487276195509 0.1736657701379 no 2836 0.199477989443254 3859 573381
SGTC_838 0109-0203 71.4 µM -0.845165254323103 0.17319089660333 no 2837 0.199009289462369 3901 759422
SGTC_126 0417-1624 672.48 µM -0.846171804151242 0.172906436754336 no 2838 0.198728454387655 3950 41912 YDL195W SEC31
SGTC_2729 fluphenazine 10.66 µM -0.847168195974996 0.172625141046655 no 2839 0.19845068895554 3823 3372 An atypical antipsychotic.
SGTC_840 0245-0196 390 µM -0.850288414596868 0.171746147339501 no 2840 0.197582378051667 4001 3827528
SGTC_43 0570-0105 72.5 µM -0.85133393223602 0.171452256174963 no 2841 0.197291940374153 3913 1114046 YDL195W SEC31
SGTC_2367 9070478 135.38 µM -0.852272550699973 0.171188687942021 no 2842 0.197031418676358 3860 572802
SGTC_880 0833-0487 87.2 µM -0.855301871377477 0.170339809845291 no 2843 0.196192025906991 3901 76075
SGTC_709 3807-1509 243 µM -0.857029547611255 0.16985688885255 no 2844 0.195714277552115 3975 1886677 YPL242C IQG1
SGTC_993 3909-8757 62.7 µM -0.858924578189993 0.169328199441708 no 2845 0.195191064178502 3886 4288324 YLR208W SEC13
SGTC_1704 st028805 70.8 µM -0.860377751510282 0.168923498914902 no 2846 0.194790422955091 3950 2876101
SGTC_1986 st071812 45 µM -0.860674105807686 0.168841042267006 no 2847 0.194708779250167 3857 11838594
SGTC_1374 2889-5571 141 µM -0.861310244107447 0.168664132583158 no 2848 0.19453359755526 3946 2853281
SGTC_2012 4023501 200 µM -0.861490876528123 0.168613920540112 no 2849 0.194483871942625 3948 3477460
SGTC_117 lucigenin 22.078 µM -0.861574726202921 0.168590615346338 no 2850 0.194460791913751 3957 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2893 9048488 25.97 µM -0.865166673956336 0.16759421332374 no 2851 0.193473656989849 3967 6467338
SGTC_1206 3978-0017 132 µM -0.866671167609268 0.167177998028315 no 2852 0.193061103721902 4037 3873677
SGTC_1025 k007-0731 70 µM -0.867037896824515 0.167076644189978 no 2853 0.192960622906476 3897 6256118
SGTC_3250 9135583 49.47 µM -0.868111287958759 0.166780216244452 no 2854 0.192666706081684 3955 7699353
SGTC_474 dl-dihydrosphingosine 5 µM -0.869296673116702 0.166453254522699 no 2855 0.192342441050762 3924 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.869733514004599 0.166332866254263 no 2856 0.192223026358547 4017 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2904 7225135 42.03 µM -0.870855924892132 0.1660238007722 no 2857 0.191916412479297 4021 4446116
SGTC_2387 9077560 195.08 µM -0.871182230845136 0.165934019290089 no 2858 0.191827330256392 3905 5303272
SGTC_624 k048-0052 28 µM -0.871198898258975 0.16592943417541 no 2859 0.191822780696446 3916 6835531
SGTC_775 4577-0580 57.3 µM -0.872842654890299 0.165477647942114 no 2860 0.191374423220049 4023 2006902
SGTC_438 sphingosine 6.67 µM -0.873040144414788 0.165423421573729 no 2861 0.191320598455699 3901 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_506 n9-isopropylolomoucine 153 µM -0.873330366157066 0.165343753799166 no 2862 0.191241516835967 3919 6610355
SGTC_2677 mitomycin C 100 µM -0.873619607756032 0.165264379784796 no 2863 0.191162722232468 3943 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1605 st000082 49.1 µM -0.873700353025353 0.165242225978021 no 2864 0.19114072932613 3934 1114022
SGTC_3070 9117005 49.47 µM -0.87455282796123 0.165008452575083 no 2865 0.19090863204023 3972 8779016
SGTC_919 tnp00227 403.569 nM -0.874676771680947 0.164974481444094 no 2866 0.19087490116719 3922 1269246 A methoxyflavone. YNL221C POP1
SGTC_2675 theaflavin digallate 100 µM -0.876321470178926 0.164524122842891 no 2867 0.190427648159329 3884 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_883 0850-0245 24.6 µM -0.878005517898673 0.164063815877766 no 2868 0.189970362132928 4029 6823229 YPR165W RHO1
SGTC_3131 9127911 49.47 µM -0.88450518564059 0.162295080591178 no 2869 0.188211782186007 3995 45595681
SGTC_1769 st044406 64.4 µM -0.884697313274103 0.16224298705847 no 2870 0.188159952571722 3943 670903
SGTC_2465 5809242 33.21 µM -0.885835669789208 0.161934556162707 no 2871 0.187853042762807 3961 2731748
SGTC_82 0054-0107 293.755 µM -0.88606155600857 0.161873399089027 no 2872 0.187792178851339 3916 3104697
SGTC_254 nsc-64875 3.808 µM -0.886113910287417 0.161859226691923 no 2873 0.187778073991595 3984 56993
SGTC_3022 9087993 49.47 µM -0.886412360137715 0.161778451223615 no 2874 0.187697680581679 4001 17173644
SGTC_504 lovastatin 124 µM -0.886580944230941 0.161732835541551 no 2875 0.187652278497807 3977 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2868 9035608 32.47 µM -0.8883068517637 0.161266319690003 no 2876 0.187187857528919 3921 6462614
SGTC_890 0929-0006 47.2 µM -0.889133563041077 0.161043169416362 no 2877 0.186965651464179 3927 1378169
SGTC_2317 5986382 200 µM -0.893538753059155 0.159857496691918 no 2878 0.185784364345374 3981 877883
SGTC_1548 st061468 90.8 µM -0.894039026917973 0.159723208163901 no 2879 0.185650505233772 3947 390799
SGTC_1264 0783-0040 158 µM -0.894696931606777 0.159546719181371 no 2880 0.185474559697699 3861 2855798
SGTC_3330 9141424 71.43 µM -0.895087630352379 0.159441971081352 no 2881 0.185370122891861 4044 27261020
SGTC_2171 5739187 198.077 µM -0.895145564090445 0.159426442618078 no 2882 0.18535463986294 3898 2262761
SGTC_2145 5634607 200 µM -0.89551163912729 0.159328343366772 no 2883 0.185256823375667 3930 308662
SGTC_870 0573-2213 57.6 µM -0.895515165916437 0.159327398464901 no 2884 0.18525588116161 3947 3916321
SGTC_1765 st044815 90.4 µM -0.896743157655435 0.158998616416506 no 2885 0.184927992829805 4004 645695
SGTC_632 0781-2353 4.65 µM -0.897841491806004 0.158704925735081 no 2886 0.184635030333658 4033 6811515 YHR007C ERG11
SGTC_118 0083-0097 135.343 µM -0.89817437041257 0.158615985444194 no 2887 0.18454629747903 3988 5207356
SGTC_909 3448-9333 149 µM -0.898192153977682 0.158611234855778 no 2888 0.184541557799124 3891 3344074
SGTC_3208 9114115 49.47 µM -0.899066101923752 0.158377888919384 no 2889 0.184308726274561 4002 650895
SGTC_1578 josamycin 24.2 µM -0.899119741521336 0.158363574373504 no 2890 0.184294441918138 3968 5282165 A P450 substrate.
SGTC_823 0417-1665 178 µM -0.900388328160146 0.158025280075295 no 2891 0.183956815008114 3960 3429856
SGTC_3053 9095903 49.47 µM -0.900412456081323 0.158018850477674 no 2892 0.183950397237772 4063 17174018
SGTC_162 k030-0015 37.8 µM -0.900741027143592 0.15793131010228 no 2893 0.183863014708374 4048 1809920 YMR134W ERG29
SGTC_796 1234-0020 70.7 µM -0.900887544973145 0.157892283987121 no 2894 0.18382405704889 3893 46495034
SGTC_3229 9132204 49.47 µM -0.904382796569103 0.156963175261473 no 2895 0.182896228570654 4022 17682924
SGTC_371 0195-0006 7.36 µM -0.906880329445945 0.156301488063866 no 2896 0.182235042148594 3827 3928593
SGTC_1911 st060208 74.3 µM -0.907105039283024 0.156242044489256 no 2897 0.18217562674226 4029 688783
SGTC_3252 9135871 49.47 µM -0.907313221493498 0.156186986339352 no 2898 0.182120592203177 3995 17682838
SGTC_3077 9117319 49.47 µM -0.909291237900257 0.155664496229288 no 2899 0.181598207249732 3943 17154678
SGTC_457 grayanotoxin iii 135 µM -0.910034315620838 0.155468511562685 no 2900 0.181402206414207 3865 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2766 oltipraz 83.91 µM -0.911680705858568 0.155034860937698 no 2901 0.18096841180096 3925 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3082 9117008 49.47 µM -0.912297603571649 0.154872579196899 no 2902 0.180806037757496 4056 41448529
SGTC_313 3474-0040 5.03 µM -0.915382636688098 0.154062711396269 no 2903 0.179995395219675 3984 1043375 YIL048W NEO1
SGTC_997 3996-0078 137 µM -0.915427876032082 0.154050856266982 no 2904 0.1799835248515 4025 735687
SGTC_1471 k673-0312 37 µM -0.915920459763727 0.153921812030229 no 2905 0.179854307441585 3936 24099884
SGTC_2778 tioconazole 65.09 nM -0.917469125703825 0.15351656759963 no 2906 0.179448432155683 3894 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_365 0121-0052 13.6 µM -0.917975878775295 0.15338411745711 no 2907 0.179315747140032 4039 3101739
SGTC_3296 9122258 64.045 µM -0.918917692339161 0.153138156617538 no 2908 0.179069312562715 3998 4730474
SGTC_3141 9094609 49.47 µM -0.920395090445958 0.152752851261963 no 2909 0.178683166654999 3947 25236309 YDL196W YDL196W
SGTC_62 0180-0423 3.232 µM -0.922166737794288 0.152291654276418 no 2910 0.178220805048189 3946 30102 YGL099W LSG1
SGTC_981 1488-1094 54.9 µM -0.922423742874974 0.152224827314861 no 2911 0.178153794967567 3959 3449522
SGTC_90 0870-0863 4.608 µM -0.924555033389449 0.151671395272059 no 2912 0.177598706187787 3997 1738164
SGTC_36 0335-0881 14.2 µM -0.925380576979822 0.151457386200706 no 2913 0.177383989203428 3910 23828853
SGTC_149 3970-0822 46.1 µM -0.925576656160525 0.151406585307873 no 2914 0.17733301474498 4016 3114250 YBL034C STU1
SGTC_3156 9099931 49.47 µM -0.927720143876917 0.150851981887598 no 2915 0.176776378276794 4016 18111053
SGTC_1131 3454-3128 32.3 µM -0.931146639910769 0.149968226620134 no 2916 0.175888857759875 4063 710982
SGTC_1648 st011736 69.8 µM -0.932064734362276 0.149732021095071 no 2917 0.175651535928638 4003 2855514
SGTC_2900 5328528 85.29 µM -0.933546687277482 0.14935127108775 no 2918 0.175268888412479 4018 795359
SGTC_664 1222-0054 14.9 µM -0.933826621929755 0.149279421662695 no 2919 0.175196667310594 3977 6813991
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.934152408266608 0.149195832778985 no 2920 0.175112640576004 3993 15053
SGTC_2133 5320837 200 µM -0.936532066018337 0.148586218343569 no 2921 0.174499655345709 4048 2841355
SGTC_1218 1348-1416 30.7 µM -0.937106316395834 0.148439358181331 no 2922 0.17435193633904 3954 6787668
SGTC_2529 gangaleoidin 93.61 µM -0.941278268840156 0.147375328196765 no 2923 0.173281138046258 4041 4565183
SGTC_122 0236-0016 402.397 µM -0.944761884451762 0.146490779292022 no 2924 0.172390227539924 4021 6808838
SGTC_1011 4112-3381 17.4 µM -0.946842571465632 0.145964161075705 no 2925 0.171859502573074 4101 2877139
SGTC_3165 9101544 49.47 µM -0.947629214358328 0.145765394926219 no 2926 0.171659124102038 4040 5002184
SGTC_3334 9142812 21.919 µM -0.948784316895871 0.145473857562401 no 2927 0.171365159951751 4047 45283678
SGTC_17 0960-0276 49.807 µM -0.949735253797694 0.145234144253356 no 2928 0.171123395937158 4028 6821114
SGTC_3016 9080866 49.47 µM -0.953767509613149 0.144220642486474 no 2929 0.170100669507252 4020 17066299
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.954593835126991 0.144013536838022 no 2930 0.169891567989077 4050 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1053 3366-3204 134 µM -0.956788068080453 0.14346456030772 no 2931 0.16933711797065 4062 3632071 YPR165W RHO1
SGTC_3293 9120939 62.045 µM -0.957819825480506 0.143206913246716 no 2932 0.169076810143632 4040 934087
SGTC_947 3447-0010 211 µM -0.958246671959031 0.143100413999056 no 2933 0.168969193854005 3994 748350
SGTC_2206 7254556 146.969 µM -0.95842576727166 0.143055745216223 no 2934 0.168924053552591 4040 4398905
SGTC_1419 3993-2473 62.6 µM -0.959928012278288 0.142681436011026 no 2935 0.168545723395592 4106 704026
SGTC_171 k064-0041 9.68 µM -0.961451143127296 0.142302599372601 no 2936 0.168162689880737 4069 53325
SGTC_2189 6047310 154.431 µM -0.96594086870194 0.141189866883873 no 2937 0.167036885267632 4025 711535
SGTC_2227 7312221 64.1025 µM -0.966458756453514 0.141061894237872 no 2938 0.166907337593926 4111 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3318 9139014 38.6185 µM -0.966882504755949 0.140957242450295 no 2939 0.166801386769613 4044 16643984
SGTC_2735 sertaconazole 140 nM -0.967043454378293 0.140917507031054 no 2940 0.166761155514813 4167 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2665 lovastatin 100 µM -0.969141987682721 0.140400114222615 no 2941 0.166237175444286 4073 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_355 1311-2252 105 µM -0.969377550604119 0.140342116874742 no 2942 0.166178424497022 4039 5338538
SGTC_3121 9125696 49.47 µM -0.970641534987017 0.140031192376925 no 2943 0.165863407553722 4128 1235365
SGTC_429 1112-0049 25.5 µM -0.973081252885676 0.139432376460435 no 2944 0.165256460315654 4021 2836170
SGTC_3344 9148862 3.898 µM -0.975486724448438 0.138843673860391 no 2945 0.164659441847062 4111 4905352
SGTC_2580 diallyl disulphide 81.36 µM -0.975489130477352 0.13884308587002 no 2946 0.164658845390729 4053 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1146 3579-1023 7 µM -0.975717257594109 0.138787343391251 no 2947 0.164602298870073 4103 X1146
SGTC_1737 st035557 69.7 µM -0.975724759589639 0.138785510550103 no 2948 0.164600439542729 3937 5716916
SGTC_63 0099-0242 26.702 µM -0.977808882719975 0.138276968821934 no 2949 0.164084428465984 4101 3898502 YLR359W ADE13
SGTC_1395 3486-0190 4.35 µM -0.980438191964003 0.137637211841741 no 2950 0.163434932613735 4050 6748079
SGTC_3072 9116419 49.47 µM -0.982520175433641 0.137132064137406 no 2951 0.162921824241059 4108 17170162
SGTC_2232 chlorophetanol 41.5365 µM -0.982925144920591 0.137033954484692 no 2952 0.162822140630433 4130 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2092 5303694 80.6725 µM -0.985176246695787 0.136489467230054 no 2953 0.162268753048584 4063 1963699
SGTC_1763 st044482 94.5 µM -0.985431386890052 0.136427848459108 no 2954 0.162206109366192 4064 88505
SGTC_452 diindolylmethane 8 µM -0.987707685015278 0.135878943146584 no 2955 0.161647914842976 4083 3071 Inhibits expression of several cancer promoting factors.
SGTC_1274 0865-0114 173 µM -0.98940300455847 0.135471118534004 no 2956 0.161233002551388 4070 870624
SGTC_1809 st050081 57.6 µM -0.990685945791655 0.135163053394663 no 2957 0.160919477898881 4170 5036894
SGTC_3302 9125395 16.351 µM -0.992877124871583 0.134638009929214 no 2958 0.160384919369672 4029 17599668
SGTC_754 3474-0146 171 µM -0.993338812025229 0.134527560681522 no 2959 0.160272434665074 4049 24762078
SGTC_2458 5808907 16.39 µM -0.993354499423305 0.13452380888397 no 2960 0.160268613518999 4230 2731747
SGTC_143 4032-1194 15.74 µM -0.99360987278525 0.134462743901704 no 2961 0.160206417892826 4096 1806963
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.993641790021835 0.134455113177197 no 2962 0.160198645628693 4102 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2202 7226349 200 µM -0.993727410107901 0.134434644725422 no 2963 0.160177797236536 4032 844334
SGTC_2385 9074692 200 µM -0.994736730290339 0.134193516553421 no 2964 0.159932162638431 4098 17046906
SGTC_805 3852-0218 479 µM -0.995177097155422 0.134088405358946 no 2965 0.159825069383059 4030 6615355
SGTC_1292 0kpi-0043 232 µM -0.995367661791547 0.134042937013463 no 2966 0.159778740326006 4100 3333905
SGTC_1735 st034310 56.75 µM -0.997254961987762 0.133593202877422 no 2967 0.159320384419943 4152 871153
SGTC_921 1561-0023 372 µM -0.999619547350451 0.133031199962927 no 2968 0.158747329846645 4053 24050882
SGTC_203 k066-0004 30.888 µM -1.00417064070712 0.131954104450009 no 2969 0.15764818542065 4174 6795412
SGTC_1701 st028638 40.4 µM -1.00504164552067 0.131748653659501 no 2970 0.15743839852791 4101 3490878
SGTC_3115 9123671 49.47 µM -1.0054559716248 0.13165100079352 no 2971 0.15733866995366 4206 3286988
SGTC_1433 4060-0023 7.6 µM -1.00564877114078 0.131605576748392 no 2972 0.157292277140766 4110 3840627
SGTC_569 4130-2812 160 µM -1.00701476557347 0.131284054878016 no 2973 0.156963839293541 3902 743552
SGTC_2540 epiandrosterone 100 µM -1.00838837285115 0.130961288529866 no 2974 0.156634026286166 4132 441302 A steroid.
SGTC_2339 9000433 200 µM -1.00856754020894 0.130919228750612 no 2975 0.156591040569018 4124 2988954
SGTC_2033 5192550 145 µM -1.00941608121581 0.13072015939835 no 2976 0.156387564654346 4099 182073
SGTC_2733 amorolfine 100 µM -1.00960961771538 0.130674784684259 no 2977 0.156341179962246 4204 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3268 9137683 49.47 µM -1.01268424913805 0.129955396404108 no 2978 0.15560550181316 4149 1953228
SGTC_2253 7938677 135.83 µM -1.01363171138705 0.129734267120698 no 2979 0.155379260086489 4173 2301972
SGTC_1070 indatraline 8.81 µM -1.01381317885488 0.129691943975018 no 2980 0.155335952784152 4121 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_538 2922-0838 53.3 µM -1.01543775831838 0.129313473885013 no 2981 0.154948600986153 4110 777039
SGTC_1841 st054148 70 µM -1.01586062753594 0.129215085855146 no 2982 0.154847880141243 4127 675442
SGTC_1478 0453-0656 35.7 µM -1.01751269752494 0.12883119988307 no 2983 0.154454797487296 4093 5258496
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.01819177658423 0.128673634215948 no 2984 0.154293413355511 4085 688803
SGTC_123 0083-0120 66.675 µM -1.02322799241706 0.127509261770518 no 2985 0.153100030332689 4082 16001701
SGTC_231 b-estradiol 524 µM -1.02425990366773 0.12727159126363 no 2986 0.152856265593071 4100 450 A steroid.
SGTC_2484 5809818 12.04 µM -1.02559886604899 0.126963660146071 no 2987 0.152540351095636 4083 2870548
SGTC_2719 novobiocin 32.65 µM -1.02915288864658 0.126148831488945 no 2988 0.151703918225456 4140 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2805 7950783 58.44 µM -1.0312829610655 0.125662221791853 no 2989 0.151204073125836 4147 1178958 YDL195W SEC31
SGTC_385 1494-0393 12.4 µM -1.0341094557691 0.125018540240128 no 2990 0.150542498121905 4115 3090647
SGTC_2023 5144124 124 µM -1.03413724482901 0.125012223252754 no 2991 0.150536003344812 4111 2830192
SGTC_2400 5203494 178.7 µM -1.03491091578181 0.124836442482347 no 2992 0.150355258183647 4040 6777674
SGTC_1840 st055363 71 µM -1.03620039029374 0.124543853261247 no 2993 0.150054332367675 4177 676033
SGTC_2419 paclitaxel 166.5 µM -1.03646243221764 0.124484453093629 no 2994 0.149993228535992 4053 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1865 st057639 52.2 µM -1.03887267925652 0.123939022573744 no 2995 0.149431977079437 4109 688818
SGTC_2853 9015042 58.44 µM -1.04199216868121 0.123235579263058 no 2996 0.148707654889371 4051 6457456
SGTC_1857 st056007 79.3 µM -1.04298764912634 0.123011688928054 no 2997 0.148477006518828 4111 619834
SGTC_307 1501-1223 22.3 µM -1.04422891601137 0.122732919205496 no 2998 0.148189745818399 4172 2830329
SGTC_2356 9061756 188.97 µM -1.0455102000087 0.122445627321091 no 2999 0.147893614424696 4163 20104043
SGTC_1990 st072050 59.8 µM -1.0457094534166 0.122400992786566 no 3000 0.147847598435227 4127 17233948
SGTC_691 1548-0686 185 µM -1.04975909136592 0.121496311487504 no 3001 0.146914443972835 4134 46495133
SGTC_195 4234-0266 16.654 µM -1.05021859799861 0.121393956302038 no 3002 0.146808810367077 4129 2303354
SGTC_572 0960-0087 17.7 µM -1.05058149465636 0.121313163864029 no 3003 0.146725421947724 4122 6796365
SGTC_1497 4476-2978 41.3 µM -1.05093472517303 0.121234559739858 no 3004 0.146644285195507 4182 1528379
SGTC_1722 st034304 3.6505 µM -1.05133250623842 0.121146084703751 no 3005 0.14655295127054 4131 4036148 YLR033W RSC58
SGTC_2936 9038235 15.59 µM -1.05284817175643 0.120809384453549 no 3006 0.146205291495501 4083 4749415
SGTC_1547 harmine 94.2 µM -1.05372688781419 0.120614482372349 no 3007 0.146003987541074 4116 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2440 5628896 157.78 µM -1.05511254223452 0.120307589706077 no 3008 0.145686928241685 4132 5522048
SGTC_849 0386-0493 241 µM -1.05526915912077 0.120272937064764 no 3009 0.145651120998037 4120 726119
SGTC_1778 st046819 58.9 µM -1.05873961400155 0.119506877023982 no 3010 0.144859190729672 4196 671715
SGTC_1357 1503-1303 39.5 µM -1.05881844422869 0.119489516299245 no 3011 0.144841236037789 4117 292895
SGTC_1484 3473-2379 286 µM -1.06030450901492 0.119162574191453 no 3012 0.144503044288986 4274 671917
SGTC_2695 st077686 51.995 µM -1.06058282741298 0.119101412948227 no 3013 0.144439765077952 4183 2876092
SGTC_96 0929-0093 37.281 µM -1.06106825100518 0.118994792803378 no 3014 0.144329442571677 4158 6991579
SGTC_1182 1222-0449 220 µM -1.06157189413516 0.11888424211274 no 3015 0.144215039347521 4146 658318
SGTC_2710 st078562 53.7235 µM -1.06228932002845 0.118726890958865 no 3016 0.144052180669278 4096 17250908
SGTC_703 3875-0075 71.8 µM -1.06435048095792 0.118275640647661 no 3017 0.143584978747187 4203 2850814
SGTC_586 0957-0265 8.15 µM -1.06483963991142 0.11816872726776 no 3018 0.143474251755017 4029 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1864 st057645 30.4 µM -1.06596903099941 0.117922142191606 no 3019 0.143218820789043 4196 688666
SGTC_3237 9133362 49.47 µM -1.06731977571906 0.117627706303352 no 3020 0.142913730519303 4136 43845137
SGTC_1788 fluconazole 20 µM -1.06772733076574 0.117538969569139 no 3021 0.142821763115587 4202 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3280 9140961 49.47 µM -1.06876706132801 0.117312804315225 no 3022 0.142587322499138 4192 4901226
SGTC_2449 5812982 45.77 µM -1.07152553595003 0.116714266893743 no 3023 0.141966597532892 4097 776185
SGTC_3092 9117248 49.47 µM -1.07226874964105 0.1165533743291 no 3024 0.141799669406832 4277 17141857
SGTC_2682 pyrogallin 40.03 µM -1.07409455451882 0.11615878803609 no 3025 0.141390152472385 4161 822798 An ATP competetive kinase inhibitor.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.07421738459089 0.116132276525755 no 3026 0.14136263123939 4176 4620898
SGTC_1676 st018489 23.4 µM -1.07733273355701 0.115461298267164 no 3027 0.140665821784729 4196 3696235
SGTC_1438 4092-1045 4 µM -1.07789875111226 0.11533968674046 no 3028 0.140539471420192 4178 1351342
SGTC_3116 9124943 49.47 µM -1.0787451282202 0.115158008541405 no 3029 0.140350681024296 4156 41905195 YPL160W CDC60
SGTC_1915 st067105 30.6 µM -1.07939791045347 0.1150180252924 no 3030 0.140205191020055 4111 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2409 alverine citrate 63.97 µM -1.07975307339197 0.114941914660663 no 3031 0.140126076493005 4295 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1903 st060211 78.3 µM -1.08108478222107 0.114656851397234 no 3032 0.139829701008306 4206 688960
SGTC_962 1254-0300 21.5 µM -1.08274442601769 0.114302295596679 no 3033 0.139460939484177 4147 7340576
SGTC_3054 9094397 49.47 µM -1.08293871294208 0.114260840469382 no 3034 0.139417813547597 4168 2598354
SGTC_2963 9082507 9 µM -1.08333143845944 0.114177077067235 no 3035 0.13933066783191 4216 16459611
SGTC_3113 9123498 49.47 µM -1.08361503601937 0.114116616482915 no 3036 0.139267760637847 4270 8897275
SGTC_338 4055-0136 114 µM -1.08423345607897 0.113984853686049 no 3037 0.139130650638494 4147 2900563
SGTC_1119 parthenolide 318.541 nM -1.08679819932516 0.11343955728263 no 3038 0.138563001869378 4277 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2247 cerulenin 830 nM -1.08767727218125 0.113253084222027 no 3039 0.138368802306477 4236 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_250 brefeldin a 552.239 µM -1.09106103384703 0.112537345913249 no 3040 0.137623013641899 4054 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2291 7917025 104.35 µM -1.0928208365123 0.112166389573362 no 3041 0.137236235617388 4103 2964612
SGTC_681 1642-0006 26.6 µM -1.09848390372706 0.110978581300993 no 3042 0.135996621255526 4212 4446530
SGTC_9 0092-0002 10.449 µM -1.09891782712416 0.110887940440582 no 3043 0.135901954992402 4180 759368
SGTC_2792 7535235 81.82 µM -1.09927826184538 0.110812690724849 no 3044 0.135823355591751 4187 1281891
SGTC_2978 9011784 42.97 µM -1.09948660487504 0.110769210624052 no 3045 0.135777936774222 4171 2994934
SGTC_2098 5376439 882.5 nM -1.10118672677568 0.110414860908379 no 3046 0.1354076986651 4233 2844116
SGTC_2302 7771753 200 µM -1.1033883345729 0.109957197177787 no 3047 0.134929280200037 4206 2203047
SGTC_5 0352-0601 109.883 µM -1.10596716790689 0.109422849897435 no 3048 0.134370365179933 4116 762456
SGTC_120 rhodamine 6G 52.259 µM -1.10935599865211 0.108723506394515 no 3049 0.133638318185604 4207 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2062 5245942 200 µM -1.11468777052272 0.107629720156376 no 3050 0.132492121733725 4250 1376160
SGTC_2956 9076196 2.52 µM -1.11531843817277 0.107500868099757 no 3051 0.1323569934564 4217 16423868
SGTC_2470 5664817 21.68 µM -1.11567250481789 0.107428577292956 no 3052 0.132281171982218 4242 2859561
SGTC_1076 itraconazole 331 nM -1.12372820759606 0.105793278957374 no 3053 0.130564173034118 4218 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1777 st045864 34.765 µM -1.12394185798045 0.10575015447713 no 3054 0.130518846172063 4203 4691462
SGTC_1490 4089-0339 670 nM -1.12424188027437 0.105689617625071 no 3055 0.130455213503976 4188 742542
SGTC_1511 0906-3109 28.5 µM -1.12808091172507 0.104917209416209 no 3056 0.129642874883125 4232 2882180
SGTC_375 3970-0961 9.27 µM -1.12901585377226 0.104729720661443 no 3057 0.129445572933123 4171 2898222
SGTC_1222 0366-0074 1.18 µM -1.13044331318133 0.104443933092042 no 3058 0.129144735950971 4235 286520
SGTC_1694 st024011 44.9 µM -1.13136727923775 0.104259249990993 no 3059 0.128950268769172 4252 2787533
SGTC_1697 st025554 27.742 µM -1.13508444305284 0.103518651820234 no 3060 0.128169969561728 4221 1269519
SGTC_61 0978-8327 98.565 µM -1.13551414886117 0.103433285152633 no 3061 0.128079978528806 4146 6150059 YHR072W ERG7
SGTC_2464 5717415 7.67 µM -1.13701252482821 0.103136012970989 no 3062 0.127766524904393 4210 5285744
SGTC_412 gemfibrozil 100 µM -1.13979714732368 0.102585203267267 no 3063 0.127185411241464 4153 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2009 4012297 12.05 µM -1.14350693897022 0.101854717773117 no 3064 0.126414087687091 4225 45595307
SGTC_1743 st037606 46.3785 µM -1.14426209583882 0.101706486714795 no 3065 0.126257478870788 4207 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1978 st071761 42 µM -1.14623546008484 0.101319873208498 no 3066 0.125848869653667 4268 5147680
SGTC_2728 chlorpromazine 9.18 µM -1.15130748898413 0.100331096795377 no 3067 0.124802878640455 4323 2726 A thorazine and dopamine antagonist.
SGTC_3074 9116018 49.47 µM -1.1518775074441 0.100220415176851 no 3068 0.124685706097279 4303 17027303
SGTC_1189 1431-2119 7.28 µM -1.15226027091056 0.100146143267732 no 3069 0.124607068704341 4230 3107275
SGTC_1299 1079-1439 3.74 µM -1.15409370142744 0.0997909392639901 no 3070 0.124230877693245 4207 323161
SGTC_614 0462-0418 107 µM -1.1544376835738 0.0997243997269664 no 3071 0.124160386584844 4011 5188303
SGTC_2087 5276107 200 µM -1.15672141243819 0.0992834594989993 no 3072 0.123693099249929 4206 144405
SGTC_451 chloral hydrate 100 µM -1.16482698412978 0.0977299528341178 no 3073 0.122044516900469 4273 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1504 k297-0033 30 µM -1.16649843457259 0.0974118325371989 no 3074 0.121706490571212 4132 4388117
SGTC_2804 7954240 19.48 µM -1.16675706665069 0.0973626760950391 no 3075 0.121654244859372 4280 828705
SGTC_427 1354-0053 47.3 µM -1.16902528442266 0.0969323507714663 no 3076 0.121196722239655 4328 6813657
SGTC_94 0334-0113 514.748 µM -1.1690461038059 0.0969284074044046 no 3077 0.12119252837073 4275 6795178
SGTC_2671 danthron 100 µM -1.17103223447323 0.0965527588240458 no 3078 0.120792910272967 4252 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.17209857174993 0.0963515179694685 no 3079 0.120578741644782 4355 688801
SGTC_1159 4092-0538 61.2 µM -1.17483064731924 0.0958373232772702 no 3080 0.120031238136086 4299 717301
SGTC_1850 st056238 17 µM -1.18144465600699 0.094600886283995 no 3081 0.118713063485688 4282 5393177
SGTC_3338 9144300 39.5675 µM -1.1839346609009 0.0941384591176416 no 3082 0.118219464157973 4264 4901274
SGTC_1290 0986-0249 10.2 µM -1.18515071406638 0.0939132288196986 no 3083 0.117978931328436 4125 53329
SGTC_1337 1486-1011 40.3 µM -1.18585543520785 0.0937828866202672 no 3084 0.117839697479533 4241 X1337
SGTC_1802 st050112 57.9 µM -1.18664071667026 0.0936378016969272 no 3085 0.117684684099998 4270 4662563
SGTC_2323 6148992 148.28 µM -1.18748619771823 0.0934817799284009 no 3086 0.117517948819805 4243 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_370 0180-0345 38.7 µM -1.18947628187821 0.0931152955929818 no 3087 0.117126149443179 4121 3989527
SGTC_782 0083-0095 30.5 µM -1.1911540382098 0.0928071538995362 no 3088 0.116796559564899 4251 3591729 An indicator and reagent.
SGTC_1512 0259-0544 12.2 µM -1.19124564002931 0.0927903517723524 no 3089 0.116778583627117 4247 18476
SGTC_226 1,3-diallylurea 8.28947 mM -1.19246278750352 0.0925673091305021 no 3090 0.116539916806475 4208 74537 YKL182W FAS1
SGTC_2683 piperine 63.03 µM -1.1945110184992 0.0921928658712108 no 3091 0.116139066595893 4260 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2222 6885208 172.143 µM -1.19489456612323 0.092122873189673 no 3092 0.116064113098676 4254 609514
SGTC_1412 3909-8563 178 µM -1.19740457870044 0.091665797923845 no 3093 0.115574449940197 4364 23767530
SGTC_543 3844-1095 191 µM -1.19771794272211 0.0916088522785162 no 3094 0.115513420858159 4279 4230703
SGTC_359 0081-0058 15.9 µM -1.20414304565668 0.090447031530394 no 3095 0.114267147414932 4374 3494159
SGTC_928 2764-0428 58.7 µM -1.20446718275314 0.0903887105869053 no 3096 0.114204529424229 4306 662578
SGTC_630 4356-0227 183 µM -1.20570788547532 0.0901657329481444 no 3097 0.113965071738698 4229 779312
SGTC_3233 9132340 49.47 µM -1.20580222183197 0.090148795659114 no 3098 0.113946879310034 4291 17682950
SGTC_2245 6637752 200 µM -1.20597217688036 0.090118287643266 no 3099 0.113914109309487 4338 681890
SGTC_509 pifithrin 175 µM -1.20912515223886 0.0895536987405001 no 3100 0.113307383720011 4370 4817 A p53 inhibitor.
SGTC_2404 5161160 200 µM -1.21775387929424 0.0880220466946805 no 3101 0.111658757750648 4247 2831543
SGTC_1323 1348-1351 11.2 µM -1.21789498004418 0.087997163782652 no 3102 0.111631942052436 4288 6989654
SGTC_1408 3909-7976 48.8 µM -1.22040087019199 0.087556127028879 no 3103 0.111156473824656 4354 24152374
SGTC_2334 9017922 200 µM -1.22232027918336 0.0872194281594111 no 3104 0.110793266680626 4353 3163164
SGTC_1236 0330-0013 258 µM -1.22596809832623 0.0865822012034126 no 3105 0.110105340168354 4316 4617066
SGTC_325 2810-4341 181 µM -1.22644883179266 0.0864984834693398 no 3106 0.11001490973486 4307 774970
SGTC_2911 7942208 15.64 µM -1.2264883345104 0.0864916069269655 no 3107 0.110007481276511 4337 1243384
SGTC_517 1365-0151 113 µM -1.22742979236741 0.0863278410251086 no 3108 0.109830547273387 4336 768657
SGTC_1321 1326-2144 215 µM -1.22750553695242 0.0863146753957343 no 3109 0.109816321007166 4301 3513030
SGTC_2364 9055074 200 µM -1.23036851714906 0.0858181436366563 no 3110 0.109279568600286 4314 6470630
SGTC_663 1486-0733 13.9 µM -1.23124677458676 0.0856662552193011 no 3111 0.109115291027741 4319 722445 YPR165W RHO1
SGTC_2783 7738165 71.43 µM -1.23184016807904 0.0855637459983473 no 3112 0.10900439760834 4307 17201110
SGTC_215 1287-0124 461.5 µM -1.23217576462816 0.0855058120928717 no 3113 0.108941717174031 4319 5560863
SGTC_1834 st055981 52.8 µM -1.23373657911747 0.0852367552576518 no 3114 0.108650539358281 4319 471719 YDL150W RPC53
SGTC_480 am 92016 50 µM -1.23493582120633 0.0850304584245551 no 3115 0.108427195262131 4323 2129 K+ channel blocker.
SGTC_1231 0242-0792 125 µM -1.23500935404956 0.0850178212953886 no 3116 0.10841351143035 4309 3707635
SGTC_1628 st004252 77.7 µM -1.23788622898517 0.0845245145882302 no 3117 0.107879124603924 4344 692968
SGTC_760 0568-0725 82.9 µM -1.23995695279306 0.0841707723308016 no 3118 0.107495658320467 4344 3916171
SGTC_1163 k060-0048 49.9 µM -1.24213103857002 0.0838005698037689 no 3119 0.107094109148596 4309 6809982
SGTC_2600 tangeritin 87.95 µM -1.24491794943833 0.083327806028107 no 3120 0.106580956118098 4233 68077 A bioactive flavone.
SGTC_1017 4239-0030 168 µM -1.24738391334476 0.0829111611891702 no 3121 0.106128381078792 4340 1149593
SGTC_1396 3511-0007 98.6 µM -1.24891233619164 0.0826537094670073 no 3122 0.105848569536279 4353 X1396
SGTC_1770 st043884 66.3 µM -1.25135455110733 0.0822435855510194 no 3123 0.105402575557218 4336 670149
SGTC_1564 D-Arginine 115 µM -1.25158544272178 0.08220489110218 no 3124 0.10536048088044 4337 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2800 7887935 81.82 µM -1.25216903187532 0.0821071502376604 no 3125 0.105254138871745 4327 2961002
SGTC_2152 5568786 200 µM -1.25237434802017 0.0820727842399803 no 3126 0.10521674449883 4339 5399883
SGTC_2812 7970281 58.44 µM -1.25424088934774 0.0817608578118331 no 3127 0.104877230901928 4360 2233435
SGTC_2780 5215298 71.43 µM -1.26245725853242 0.080398399740868 no 3128 0.103392148413542 4356 2834131
SGTC_353 1988-1175 58.3 µM -1.26266060645879 0.080364898966788 no 3129 0.103355588500293 4168 2788357
SGTC_952 1185-0122 232 µM -1.26505893026141 0.0799705799728899 no 3130 0.102925101894746 4300 678600
SGTC_2623 humulene 100 µM -1.26722782853427 0.0796152431430202 no 3131 0.10253691897714 4337 6187145 An anti-inflammatory.
SGTC_1302 1159-0335 255 µM -1.27337222199687 0.0786150756635201 no 3132 0.101442994805166 4361 649284
SGTC_1873 rapamycin 2 nM -1.27408655732804 0.0784994188009446 no 3133 0.101316370977455 4297 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2018 5133068 143 µM -1.27915833828082 0.0776819611809874 no 3134 0.100420651740468 4311 785362
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.27935667120644 0.0776501261474767 no 3135 0.100385742252728 4380 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1144 3486-0183 12.5 µM -1.28054763165857 0.0774591696660596 no 3136 0.10017630208296 4366 6744069
SGTC_244 nsc-207895 1.295 µM -1.28145379535431 0.077314116056365 no 3137 0.100017159580285 4122 42640
SGTC_1265 0819-1001 68.8 µM -1.29063491931465 0.0758560690846949 no 3138 0.0984151507641515 4306 3106768
SGTC_398 bronopol 33.3 µM -1.29227545403942 0.0755977567890366 no 3139 0.0981308846527395 4283 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1880 MG-132 525 µM -1.29268236124018 0.0755337905945451 no 3140 0.09806047039555 4317 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2930 9013230 14.89 µM -1.293994756983 0.0753277617593849 no 3141 0.0978336159147672 4345 2995857
SGTC_774 k060-0086 136 µM -1.29748733163235 0.0747815605684744 no 3142 0.0972317805966083 4354 5911235
SGTC_1152 3909-8331 15.9 µM -1.29882673654802 0.07457289552595 no 3143 0.097001698456295 4333 16001939
SGTC_597 k018-0003 82.8 µM -1.3007513031252 0.0742738469619483 no 3144 0.0966717976930452 4432 6786234
SGTC_2431 5490079 200 µM -1.3054520623432 0.0735472709377173 no 3145 0.0958694801871598 4404 5722345
SGTC_2173 5763948 167 µM -1.30810578532708 0.0731395034478063 no 3146 0.0954187157326925 4345 2867177
SGTC_1126 isoteolin 1.0172 µM -1.30821483752178 0.0731227837148725 no 3147 0.0954002254305699 4311 133323
SGTC_2162 5663267 200 µM -1.30921397394196 0.0729697336145954 no 3148 0.0952309400175952 4377 6456493
SGTC_3188 9110789 49.47 µM -1.31020654188945 0.0728179325893036 no 3149 0.09506298662977 4349 849217
SGTC_1187 1391-0724 117 µM -1.31175540728208 0.0725815359031107 no 3150 0.0948013376279463 4422 6997986
SGTC_2817 7995342 71.43 µM -1.31412630476874 0.0722208151230485 no 3151 0.0944018516604537 4364 18879975
SGTC_2394 5221648 200 µM -1.31713596841798 0.0717648901541801 no 3152 0.0938965261959161 4405 788586
SGTC_2427 5545055 42.75 µM -1.31760007184699 0.071694781407224 no 3153 0.0938187807747244 4297 5372858
SGTC_3333 9141820 12.094 µM -1.32056208598124 0.0712485684828618 no 3154 0.093323710828741 4366 1939433
SGTC_481 bay k-8644 50 µM -1.3217955133329 0.071063388677785 no 3155 0.0931181263903699 4339 2303 A calcium channel antagonist.
SGTC_47 0149-0135 24.25 µM -1.3223071606044 0.0709866814017173 no 3156 0.0930329446521318 4392 5239155
SGTC_2864 9034755 47.6 µM -1.32259296818887 0.070943860197826 no 3157 0.0929853869770967 4311 4930451
SGTC_1062 mesoridazine 14.2 µM -1.32449161065458 0.0706598990877475 no 3158 0.0926699137241034 4419 4078 A neuroleptic.
SGTC_2714 st079313 56.9 µM -1.32724526887376 0.0702496148863213 no 3159 0.0922137810520688 4373 2939799
SGTC_392 N-ethylmaleimide 8.33 µM -1.33211090872654 0.0695291358062909 no 3160 0.0914118731049579 4339 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_402 epigallocatechin gallate 10 µM -1.3333983260298 0.0693394568321035 no 3161 0.0912005607307189 4335 65064 An antioxidant.
SGTC_1441 4106-0040 13 µM -1.33480909095649 0.0691320626619808 no 3162 0.0909694186668891 4409 2904180
SGTC_3192 9110362 49.47 µM -1.33526858891483 0.0690646159409403 no 3163 0.0908942276610814 4386 16649480
SGTC_3025 9087895 49.47 µM -1.33621883854514 0.0689252958561485 no 3164 0.090738877669641 4355 17173641
SGTC_707 0865-0008 204 µM -1.33812292558492 0.0686467817531226 no 3165 0.0904281842831325 4431 723043
SGTC_2031 5180455 200 µM -1.33875581664183 0.0685544001289374 no 3166 0.0903250893951937 4382 29949
SGTC_3051 9093778 49.47 µM -1.3402805422879 0.0683322333207468 no 3167 0.090077077468672 4480 17217378
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.34712803853203 0.0673413332723797 no 3168 0.0889694996294665 4348 6708514
SGTC_2383 9036125 200 µM -1.34873939687052 0.0671097762368477 no 3169 0.088710343241947 4350 79580
SGTC_2597 laccaic acid a 100 µM -1.34961501480394 0.0669842057707808 no 3170 0.0885697526907962 4390 5491415 A textile dye.
SGTC_2203 7227154 166.4 µM -1.35470050937324 0.0662584957925516 no 3171 0.0877564977694467 4428 896304
SGTC_836 0330-0104 1.35 µM -1.35852040617552 0.0657174051475762 no 3172 0.087149305984374 4422 46494820
SGTC_897 1000-0139 31.4 µM -1.35913144401383 0.0656311699746289 no 3173 0.0870524702175184 4376 6151020
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.35979142091257 0.0655381266644306 no 3174 0.0869479690105251 4368 688761
SGTC_2100 5377183 190 µM -1.36870315961529 0.0642917459476301 no 3175 0.0855460411325503 4441 2844202
SGTC_2537 larixol 68.93 µM -1.36993258481448 0.0641212562777867 no 3176 0.0853539734495124 4390 6708759
SGTC_995 3931-2021 34.6 µM -1.37272247687541 0.0637356738301627 no 3177 0.084919319437395 4429 730143
SGTC_2468 5987765 72.9 µM -1.37304518252021 0.0636911903028094 no 3178 0.0848691504498903 4472 26772094
SGTC_2386 9075165 157.42 µM -1.37415137251535 0.0635388902566386 no 3179 0.0846973467833587 4398 16452277
SGTC_903 1134-0042 114 µM -1.37565731953113 0.0633320074586426 no 3180 0.0844638758011412 4421 701009
SGTC_2587 piperic acid 92.2 µM -1.37738292338472 0.0630955939442161 no 3181 0.0841969448316651 4369 5370536
SGTC_1308 1187-1617 41.4 µM -1.37893614585858 0.0628833855267574 no 3182 0.0839572211885355 4452 2882570
SGTC_1678 st019265 80.2 µM -1.38166533376645 0.0625118587118347 no 3183 0.0835372416233163 4410 5367020
SGTC_809 3998-0021 90 µM -1.38215546210426 0.0624453187273372 no 3184 0.0834619860042638 4371 715485
SGTC_2359 9039622 200 µM -1.3909796250283 0.0612567713905585 no 3185 0.0821158026694968 4391 6463596
SGTC_282 k297-0036 65.7 µM -1.39175945477707 0.061152590183088 no 3186 0.0819976257857019 4435 5061378
SGTC_2561 acetosyringone 100 µM -1.39249165008083 0.0610548987801358 no 3187 0.0818867842031524 4383 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_236 1509-0011 5.31 µM -1.39755936510159 0.0603820913207862 no 3188 0.0811227139765912 4468 3107280
SGTC_3331 9141060 1.957 µM -1.39760008514074 0.0603767087808268 no 3189 0.0811165963925357 4390 4906567 YPR165W RHO1
SGTC_906 1165-0455 526 µM -1.39846965771803 0.060261854753791 no 3190 0.0809860390487192 4420 3252859
SGTC_1670 st016595 4.04 µM -1.40134109022486 0.0598838074813981 no 3191 0.0805560496372043 4460 597879
SGTC_1905 st060207 84.5 µM -1.40726732806786 0.0591094456816874 no 3192 0.0796740668006001 4428 1948547
SGTC_1068 loratadine 26.9 µM -1.40962860461584 0.0588031024477078 no 3193 0.0793246880705072 4486 3957 A H1 histamine antagonist.
SGTC_330 1488-0319 80.1 µM -1.41839936509396 0.0576761142867978 no 3194 0.0780371004425996 4487 6846614
SGTC_1685 st024049 53.0905 µM -1.4252655951087 0.0568057562860996 no 3195 0.0770402206965602 4464 1941139
SGTC_2153 5569715 200 µM -1.42838620708004 0.0564136245179747 no 3196 0.0765903634883567 4466 2054701
SGTC_1443 4112-3303 14 µM -1.42985657039457 0.0562296016655433 no 3197 0.0763790944486852 4495 704433
SGTC_2569 tetrandrine 100 µM -1.43192582608052 0.0559714267106947 no 3198 0.0760825250968665 4465 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1300 1094-0077 113 µM -1.43271403893801 0.05587332997631 no 3199 0.0759697878934685 4427 5532636
SGTC_994 3910-0338 138 µM -1.4349544985872 0.0555952350267843 no 3200 0.0756500320687319 4520 3479481
SGTC_2300 7976697 71.57 µM -1.43592009009579 0.0554757192918644 no 3201 0.0755125405448345 4340 2236109
SGTC_1994 st072947 40.9 µM -1.43754136227318 0.0552755032440122 no 3202 0.0752821143976807 4500 5286565 YDL195W SEC31
SGTC_2589 lobaric acid 100 µM -1.44216937238185 0.0547071142743443 no 3203 0.0746272992636455 4400 73157 A novel microtubule depolymerizer.
SGTC_1786 berberine 21.6 µM -1.44562005475163 0.0542863336062253 no 3204 0.0741418992546166 4367 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1808 st050063 61.5 µM -1.44769973186048 0.0540339743911181 no 3205 0.0738505224867097 4430 4011993
SGTC_2867 9039098 71.43 µM -1.45253669532131 0.0534506226201036 no 3206 0.0731762168035822 4443 6463460
SGTC_2865 9030313 51.95 µM -1.45653408702782 0.0529723015560078 no 3207 0.0726225168380641 4458 42562754
SGTC_684 1140-0066 328 µM -1.46148115054703 0.0523850517866433 no 3208 0.0719417223690278 4494 6813534
SGTC_337 1315-0038 354 µM -1.4642453748444 0.052059177643776 no 3209 0.0715634582428149 4449 1626437
SGTC_1993 st073995 70.8 µM -1.46703819347583 0.0517315700909415 no 3210 0.0711828328969309 4489 3098394
SGTC_2764 methyldopa 94.69 µM -1.47450817904709 0.0508633641204438 no 3211 0.0701724085823605 4443 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1813 st051246 8.6015 µM -1.48326826360404 0.049860037882974 no 3212 0.0690015753796287 4441 5291959
SGTC_3347 9188721 44.724 µM -1.49680558987337 0.0483406704951222 no 3213 0.0672219256899766 4501 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2942 9052777 62.25 µM -1.49682359339388 0.0483386748035633 no 3214 0.0672195827610412 4495 6469503
SGTC_1063 disulfiram 1.84 µM -1.49985180059691 0.0480039344950564 no 3215 0.0668263978327661 4507 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_566 0958-0068 16.5 µM -1.50632932863748 0.0472941327165961 no 3216 0.065991326385339 4411 6815365
SGTC_2972 9093619 59.92 µM -1.50782747068545 0.0471311712019063 no 3217 0.0657993447114496 4457 25236256
SGTC_3207 9114163 49.47 µM -1.50928196073744 0.0469733889391931 no 3218 0.0656133713300825 4470 849233
SGTC_2552 juarezic acid 87.02 µM -1.51218227562402 0.046660028963761 no 3219 0.06524374937457 4447 1549512
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.51505495266946 0.0463513107021349 no 3220 0.0648792441449929 4419 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2301 7769476 200 µM -1.51559391881123 0.046293572683255 no 3221 0.0648110328503395 4487 977820
SGTC_1234 0326-0494 15.5 µM -1.52007822874349 0.0458154165084005 no 3222 0.0642456578167522 4565 1547813
SGTC_1460 k062-0059 9.15 µM -1.52037530831171 0.0457838800023938 no 3223 0.0642083382873116 4390 1373085
SGTC_3032 9089427 49.47 µM -1.52966937981882 0.0448060470500259 no 3224 0.063049293290156 4483 17173707
SGTC_3351 9150312 21.596 µM -1.53087561926533 0.0446803802025427 no 3225 0.0629000679534639 4432 4904905
SGTC_1784 st039334 36.3 µM -1.54958198285972 0.0427676331447378 no 3226 0.0606209400752708 4520 3496984
SGTC_271 rotenone 740 µM -1.55228220194853 0.0424970815668835 no 3227 0.0602973573150398 4555 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1681 tripelennamine 100 µM -1.55438645890596 0.0422872041376411 no 3228 0.0600461306320932 4425 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_98 0074-0023 107.663 µM -1.55544125982883 0.0421823148486754 no 3229 0.0599205070104316 4522 3563821
SGTC_3140 9094243 49.47 µM -1.55727037245621 0.0420009272393244 no 3230 0.0597031532677269 4485 19291112
SGTC_2442 5158906 48.48 µM -1.56115056448076 0.0416182305203839 no 3231 0.059244114969789 4531 1893835
SGTC_2005 4024620 188 µM -1.56246832635541 0.0414889062966174 no 3232 0.0590888509182176 4477 236743
SGTC_1016 4226-1401 38 µM -1.56384936215229 0.0413537220650597 no 3233 0.0589264743927971 4529 2901613
SGTC_583 1488-1091 88.9 µM -1.56587341873981 0.0411562402872316 no 3234 0.0586891269391388 4620 4303273
SGTC_3276 9139060 49.47 µM -1.56842240422112 0.0409086311640896 no 3235 0.0583912929400524 4613 4870619
SGTC_1425 4048-4433 7.33 µM -1.57615051587237 0.0401652982577017 no 3236 0.0574955597432263 4606 23734946
SGTC_2618 avocadyne 43.43 µM -1.57761403835294 0.040025771819778 no 3237 0.0573271526523322 4474 3015189
SGTC_1075 aripiprazole 15.2 µM -1.58122696356912 0.0396830156174496 no 3238 0.0569130761468375 4585 60795 An atypical antipschotic. YIL048W NEO1
SGTC_721 1187-1332 279 µM -1.58448796890883 0.0393756987372054 no 3239 0.0565413586800369 4546 25730
SGTC_1457 k015-0032 57.3 µM -1.58539202397614 0.0392908443358595 no 3240 0.0564386461212267 4538 4302660
SGTC_1449 4112-4002 201 µM -1.58810147665615 0.0390374266417061 no 3241 0.0561316972358411 4570 2059539
SGTC_2732 terfenadine 20 µM -1.58891328303562 0.038961757232717 no 3242 0.0560399859428181 4615 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_119 0121-0043 24.815 µM -1.59328728858805 0.0385561040348851 no 3243 0.055547878487075 4558 1092378
SGTC_3227 9130768 49.47 µM -1.59367083510981 0.0385206979787989 no 3244 0.0555048899011103 4619 17720899
SGTC_76 0433-0009 400.328 µM -1.59611714315965 0.0382954967040186 no 3245 0.0552313209539767 4587 2841569
SGTC_2838 9002687 71.43 µM -1.59655506524172 0.0382552961494908 no 3246 0.0551824610060474 4526 6457060
SGTC_3245 9134821 49.47 µM -1.59880574758013 0.0380492296251357 no 3247 0.0549318857835851 4544 17014901
SGTC_93 0109-0045 59.227 µM -1.60540850030552 0.0374499187056983 no 3248 0.0542019674798599 4646 88733
SGTC_2388 9080168 200 µM -1.60832496699949 0.037187666191052 no 3249 0.053882012658082 4566 15943073
SGTC_70 0141-0289 43.283 µM -1.6124865645678 0.0368160501758752 no 3250 0.0534280506273608 4504 352408
SGTC_1852 st056254 31.4 µM -1.61339927269572 0.0367349559247012 no 3251 0.0533288955326165 4520 442583
SGTC_528 3492-0019 172 µM -1.61717569275193 0.0364009718147307 no 3252 0.0529201808308926 4549 2869262
SGTC_1147 3809-1045 12.3 µM -1.62068609240016 0.0360927470141858 no 3253 0.0525424889053681 4573 325925
SGTC_2188 6126565 140.678 µM -1.62119508264669 0.0360482339028733 no 3254 0.0524879035219161 4471 874518
SGTC_2785 7756463 72.73 µM -1.62745759242768 0.0355042247609295 no 3255 0.0518199741575252 4521 2201551
SGTC_1609 st001574 46.4 µM -1.62854544719082 0.0354104151233466 no 3256 0.0517046404186459 4546 3960012
SGTC_2731 amoxapine 43.43 µM -1.63352405728119 0.0349836819153099 no 3257 0.0511794126399296 4710 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2168 5727979 200 µM -1.64484339331923 0.0340291589521578 no 3258 0.0500010554610984 4483 695210
SGTC_288 1315-0019 35.1 µM -1.65916489720116 0.0328522699154847 no 3259 0.0485412844649997 4601 6811474
SGTC_2072 5231554 129 µM -1.66376313450543 0.0324815960420899 no 3260 0.0480798869342521 4637 789545
SGTC_71 0417-1750 47.813 µM -1.66626742683554 0.0322811751631253 no 3261 0.0478300807240366 4525 6811472
SGTC_2020 4017018 200 µM -1.67097626294927 0.0319070863370124 no 3262 0.0473631832315012 4600 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1067 clotrimazole 1.36 µM -1.67530450081071 0.0315663988486775 no 3263 0.0469372514141189 4609 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_248 streptozotocin 5.23457 mM -1.67729471258895 0.0314107559430388 no 3264 0.0467424330003874 4614 5300 DNA alkylating agent.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.69050298186197 0.0303938183992135 no 3265 0.0454658841335806 4646 4213774
SGTC_2304 7443016 91.4 µM -1.6942679262082 0.0301089934876251 no 3266 0.0451071912074342 4539 939854
SGTC_1380 2291-0730 164 µM -1.70527430525461 0.0292890059466301 no 3267 0.0440716387105881 4597 2999191
SGTC_1060 3448-7350 82 µM -1.71217990255092 0.0287840634452127 no 3268 0.0434317599719276 4549 570178
SGTC_1515 3460-0031 42.1 µM -1.71435894080723 0.0286262407203056 no 3269 0.0432314122061031 4567 2876596
SGTC_1326 1431-2094 10.8 µM -1.71835113698224 0.0283389622763592 no 3270 0.0428662936078683 4604 616278
SGTC_2992 9074591 71.4286 µM -1.73485551001468 0.0271766511073117 no 3271 0.0413832005488569 4549 17741321
SGTC_2095 5432005 200 µM -1.73784067036074 0.0269707294240829 no 3272 0.0411194460844159 4619 783734
SGTC_1657 st012939 43.4 µM -1.74124008442583 0.0267378194474256 no 3273 0.040820751844265 4597 24207257
SGTC_2099 5377090 177.372 µM -1.74182156045625 0.0266981484867083 no 3274 0.0407698363927531 4591 2243829
SGTC_1111 tnp00062 510.699 nM -1.74784361898141 0.0262901795000884 no 3275 0.0402455549731232 4595 676306
SGTC_2408 sulbentine 18.36 µM -1.77431329368351 0.0245582616033568 no 3276 0.0380056714348418 4478 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1442 4112-3290 3 µM -1.77685937412277 0.0243968387502374 no 3277 0.0377956900240704 4634 704353
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.78105199196857 0.0241329660146478 no 3278 0.0374519787473314 4587 364106
SGTC_3304 9125678 46.087 µM -1.78748732209278 0.0237326092541475 no 3279 0.036929379689458 4576 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2662 daunorubicin 22.37 µM -1.79590299454132 0.0232174907459909 no 3280 0.0362549730626296 4512 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2267 7931562 200 µM -1.79743579833076 0.0231246892971753 no 3281 0.0361332309344446 4591 934880
SGTC_2931 9014674 55.67 µM -1.80869411337107 0.0224525970898638 no 3282 0.0352492690126897 4583 2996810
SGTC_1883 5-benzylidenerhodanine 20 µM -1.81055689792857 0.0223429975891281 no 3283 0.0351047346502737 4617 1273210
SGTC_3122 9126309 49.47 µM -1.82315177941008 0.0216137401538717 no 3284 0.0341402030358093 4701 17591206
SGTC_1893 st059353 36.1 µM -1.83456289625083 0.020970490692362 no 3285 0.0332852402627442 4634 3112488
SGTC_3198 9112019 49.47 µM -1.83660668619025 0.0208570092007918 no 3286 0.0331339897793396 4665 45595555
SGTC_2773 thioridazine 9.09 µM -1.84430374052682 0.0204342846393534 no 3287 0.0325694433410959 4630 5452 An antipsychotic.
SGTC_2240 6690706 185.951 µM -1.85702271956714 0.0197516696638519 no 3288 0.0316539608984424 4555 805876
SGTC_3309 9129340 25.759 µM -1.87541374233877 0.0187989329267192 no 3289 0.0303679130076663 4627 17158987
SGTC_651 3253-0966 34.4 µM -1.87588649320063 0.0187749670645415 no 3290 0.0303354338578704 4660 781462
SGTC_2824 7998404 51.95 µM -1.88736849128997 0.0182008269510793 no 3291 0.0295553900229478 4634 837851
SGTC_1431 4049-0260 9.09 µM -1.90789788903661 0.0172115462848128 no 3292 0.0282022075928673 4688 3854841
SGTC_295 k015-0027 31 µM -1.92871929795189 0.0162554885659032 no 3293 0.0268828595910022 4708 3887424
SGTC_2790 5423970 71.43 µM -1.93067484810827 0.0161680784870658 no 3294 0.0267616376187137 4641 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_3130 9127414 49.47 µM -1.93865557858199 0.0158155152225891 no 3295 0.0262716455393096 4689 1494646
SGTC_2357 9067248 200 µM -1.94411138906736 0.0155783070010374 no 3296 0.0259410100759954 4625 9150235
SGTC_2922 7999257 32.47 µM -1.94825691704662 0.0154001146988957 no 3297 0.0256921147275039 4653 2988377
SGTC_1267 0828-0272 9.49 µM -1.94903935345746 0.0153666793304505 no 3298 0.0256453626162302 4702 745334
SGTC_1466 k213-0079 57.5 µM -1.97479319509881 0.0143004189120145 no 3299 0.0241458108026602 4680 3657981
SGTC_341 1486-1430 230 µM -1.97567183792765 0.0142651943908967 no 3300 0.0240959782573918 4652 2054753 YPL210C SRP72
SGTC_532 1548-0774 215 µM -1.97802830446002 0.014171093136796 no 3301 0.0239627568339768 4708 5932993
SGTC_420 mitomycin C 81.9 mM -1.98102816855959 0.0140520731336368 no 3302 0.0237940573706944 4664 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_258 haloperidol 50.781 µM -1.98854070573458 0.0137577860653718 no 3303 0.0233759608673013 4673 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2990 9074105 71.4286 µM -1.99594688426817 0.0134728847536535 no 3304 0.022969852332543 4610 6502001
SGTC_744 1594-0068 283 µM -2.00022699978652 0.0133105706917369 no 3305 0.0227378787920864 4680 668392
SGTC_3301 9125354 19.7965 µM -2.024224267545 0.0124314614278944 no 3306 0.0214735408693389 4671 41905162
SGTC_2945 9067681 61.76 µM -2.03568236786438 0.0120297521435171 no 3307 0.0208911303770988 4715 16456930
SGTC_2755 lomerizine 42.69 µM -2.04318551943234 0.0117728404206661 no 3308 0.0205170383261572 4637 3949 A calcium channel blocker.
SGTC_1238 0333-0287 48.8 µM -2.04527788284534 0.0117020513574857 no 3309 0.020413734961388 4717 7226
SGTC_516 3992-2719 87.3 µM -2.05071013873081 0.0115199889649447 no 3310 0.0201475915150431 4604 5350887 YDR037W KRS1
SGTC_582 0987-0078 156 µM -2.0523073596669 0.0114669281791405 no 3311 0.0200699006085521 4714 1625765
SGTC_1221 2958-7315 257 µM -2.05352781736649 0.0114265269364332 no 3312 0.0200107073544367 4715 4562705
SGTC_1549 4'-methoxyflavonol 74.6 µM -2.06885965387184 0.0109294311780391 no 3313 0.01927962929511 4702 97141
SGTC_197 4544-0043 41.561 µM -2.07063869523998 0.0108729870152948 no 3314 0.0191962865955122 4716 896523
SGTC_78 0336-0123 156.75 µM -2.07284914512272 0.0108032089990111 no 3315 0.0190931605438779 4593 6765896
SGTC_2274 7947094 46.08 µM -2.0969090002938 0.0100685629805341 no 3316 0.0180008158269262 4687 2971028
SGTC_1034 k072-0165 12.7 µM -2.09901863865223 0.0100062762929628 no 3317 0.0179076288647284 4699 5835461
SGTC_3196 9111891 49.47 µM -2.11906496759371 0.00943099823528605 no 3318 0.0170424884213023 4681 18891510
SGTC_2091 4-phenylthiadiazole 200 µM -2.13638910310571 0.00895735553088512 no 3319 0.016323855756053 4723 270010
SGTC_1446 4239-0190 62 µM -2.19006450362468 0.00761960866424396 no 3320 0.0142597795538891 4726 1340085
SGTC_2655 perillic acid 100 µM -2.1938863217802 0.00753144199157746 no 3321 0.0141217914851902 4748 5702197 An apoptosis inducer.
SGTC_1439 4092-1168 46 µM -2.20377806841201 0.00730740586436104 no 3322 0.0137699778447073 4737 2886240
SGTC_531 3788-1495 174 µM -2.21319080371209 0.00709969534627369 no 3323 0.0134422469269481 4719 2896655
SGTC_2614 arthonioic acid 13.39 µM -2.2287420982907 0.00676792432788416 no 3324 0.0129155347353454 4625 6710684
SGTC_508 roscovitine 141 µM -2.23086442230405 0.00672372570885671 no 3325 0.012845055514796 4765 160355 A CDKinase inhibitor.
SGTC_1465 k213-0056 144 µM -2.23389839439222 0.00666098448342954 no 3326 0.0127448796210171 4678 24048857 YMR208W ERG12
SGTC_521 r062-0005 13.8 µM -2.23601856780679 0.00661744794468014 no 3327 0.0126752774560589 4680 2832033
SGTC_1534 6-azauridine 81.6 µM -2.25380231334502 0.00626206399408124 no 3328 0.0121043036118281 4750 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_471 1-acyl-paf 4 µM -2.26713906386817 0.00600674325924017 no 3329 0.0116908659448682 4725 16759367
SGTC_1037 k284-1091 78.7 µM -2.27467070756253 0.00586667104097391 no 3330 0.0114628454818023 4713 3334711
SGTC_2826 7992541 19.48 µM -2.28849404451212 0.00561710881680465 no 3331 0.0110543832690364 4717 2985066
SGTC_1822 st052468 42 µM -2.29109661531013 0.00557119181080739 no 3332 0.0109789131848462 4754 2873678
SGTC_1042 0350-0096 82 µM -2.36785010537102 0.00435858775601236 no 3333 0.00894589151960806 4732 3122515
SGTC_1355 1499-0035 1.68 µM -2.38485456932756 0.0041242228600403 no 3334 0.00854293711664602 4764 1548538
SGTC_2572 astragaloside iv 100 µM -2.3876865886379 0.00408630506242725 no 3335 0.0084773968526754 4725 45006101 An anti-inflammatory agent.
SGTC_3204 9114183 49.47 µM -2.39897752378303 0.00393821407483326 no 3336 0.00822046191324967 4698 17027248
SGTC_1848 st056003 16.4 µM -2.41962418813245 0.00367979739386171 no 3337 0.00776827729238825 4741 146492
SGTC_303 1348-1668 34.2 µM -2.46354713160146 0.00318001554382606 no 3338 0.00687849035979468 4774 5380509
SGTC_1682 st012968 530 nM -2.50947749959239 0.00272352788233389 no 3339 0.00604549591188292 4735 24207270
SGTC_2416 tofa 880 nM -2.62795094340855 0.00180627798555644 no 3340 0.00429504513156908 4746 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1363 1636-0063 10.4 µM -2.67008478636704 0.00155488769109624 no 3341 0.00379160478774445 4774 6072185
SGTC_296 1222-0039 74.9 µM -2.68613531749384 0.00146783029882163 no 3342 0.00361419039219469 4791 5984176
SGTC_2417 cerulenin 830 nM -2.71701498513053 0.00131273577940015 no 3343 0.00329368125602426 4768 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_347 4534-1311 26.2 µM -2.79441626952376 0.000987528151182748 yes 3344 0.0025996751575747 4782 2862016
SGTC_719 2810-4230 27.3 µM -2.81344633909721 0.00091981693070721 yes 3345 0.00245067829597937 4792 721079
SGTC_2961 9083290 32.55 µM -2.92956768007015 0.000590997996210533 yes 3346 0.0016971694272857 4770 17741490
SGTC_1038 k292-0204 154 µM -3.26099963301999 0.000153600684978676 yes 3347 0.000555100919864058 4762 4454212
SGTC_2964 9083345 53.42 µM -3.3468803885326 0.000106122153606337 yes 3348 0.000408632329680311 4785 17741579
SGTC_1539 benzyladenosine 56 µM -3.42465718718846 7.53666690889178e-05 yes 3349 0.000307787815300294 4806 92208 A nucleotide analog.
SGTC_3191 9110352 49.47 µM -3.7562241375826 1.61956386333135e-05 yes 3350 8.62481085766391e-05 4801 17122424
SGTC_301 4119-0100 24.5 µM -3.89287346167798 8.27964347036507e-06 yes 3351 4.95319151420625e-05 4809 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1027 k015-0025 8.67 µM -4.04947641259224 3.73613995290029e-06 yes 3352 2.56661755528489e-05 4805 3598955
SGTC_177 1327-0068 8.361 µM -4.17643563089873 1.9190879617913e-06 yes 3353 1.48056242342594e-05 4808 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_573 3702-0553 84.7 µM -4.32686410940146 8.50442773902885e-07 yes 3354 7.56236032092453e-06 4809 1222756
SGTC_172 1112-0046 2.638 µM -4.48095243679816 3.59426235310944e-07 yes 3355 3.71553360819499e-06 4807 2802135 YIL048W NEO1
SGTC_174 3553-0389 74.3 µM -5.14063884479776 6.5554403033232e-09 yes 3356 1.36902951651197e-07 4809 738071