SGTCid condition conc unit USB1|YLR132C.score USB1|YLR132C.strain.pval USB1|YLR132C.strain.significant USB1|YLR132C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_164 4100-3994 89.624 µM 7.41265764579963 1.31761364428392e-16 yes 1 6.18965818208769e-14 1 4615967
SGTC_1239 0337-0584 35.4 µM 5.28043787260089 2.79522378017981e-09 yes 2 6.44377596391186e-08 19 914301 YML130C ERO1
SGTC_601 0986-0029 62.9 µM 4.36945856094952 7.17390277459635e-07 yes 3 6.22774860199411e-06 14 24747981
SGTC_1744 st037937 38.9 µM 4.27513685370041 1.20442416150933e-06 yes 4 9.5509960897396e-06 5 1016152
SGTC_2064 5220758 200 µM 3.81733483237527 1.28303922970202e-05 yes 5 6.74505187710809e-05 9 788518
SGTC_46 0329-0187a 2.197 µM 3.64591522852204 2.92047691904513e-05 yes 6 0.000133220902919987 13 46494817
SGTC_1047 2043-3044 82 µM 3.64237326424902 2.9694586391175e-05 yes 7 0.00013506799208046 11 669592
SGTC_618 k072-0232 33.2 µM 3.63974327457133 3.00633087716205e-05 yes 8 0.000136454998180151 9 5872756 YGL099W LSG1
SGTC_1611 st001856 99.4 µM 3.63195384349071 3.11809824268934e-05 yes 9 0.000140641720188607 12 647478
SGTC_774 k060-0086 136 µM 3.62449550654765 3.22879237036517e-05 yes 10 0.000144763026802389 7 5911235
SGTC_1383 3049-0032 20.7 µM 3.56672061917193 4.22127986358588e-05 yes 11 0.000180738249880808 13 712864
SGTC_876 0720-0963 56.8 µM 3.45104653289486 7.13545479925513e-05 yes 12 0.000279208640722773 11 765861
SGTC_2002 4023503 131 µM 3.36471869845717 0.000104509115944508 yes 13 0.000383108669034009 18 4736863 YCR052W RSC6
SGTC_779 1360-0071 233 µM 3.33195355184629 0.000120523676265477 yes 14 0.000431193241680676 10 7566
SGTC_2448 5185112 27.17 µM 3.27859519343363 0.000151617388836835 yes 15 0.000521625855220507 10 5718189
SGTC_889 0919-1524 82.7 µM 3.1519898482834 0.000257944211512147 yes 16 0.000810809555391867 7 3905452
SGTC_1245 0418-0076 17.2 µM 3.08079688474371 0.000344955764543213 yes 17 0.00103223713458466 16 6790114
SGTC_1564 D-Arginine 115 µM 2.99258897527151 0.000490516085979965 yes 18 0.00138311010262232 17 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1059 3448-6867 171 µM 2.98145651683532 0.000512475107832019 yes 19 0.00143440392053777 17 3934407
SGTC_547 1120-0019 610 nM 2.95820327333521 0.00056130752957814 yes 20 0.00154718997934112 15 3676939
SGTC_359 0081-0058 15.9 µM 2.95751837637948 0.000562808998751945 yes 21 0.00155063131505864 32 3494159
SGTC_1641 st009299 47.1 µM 2.95210396646889 0.000574810124136632 yes 22 0.00157808321996409 21 4046054
SGTC_1832 st054113 55 µM 2.95025872108381 0.000578953884732776 yes 23 0.00158753964535785 13 1251267
SGTC_2757 clomiphene 4.22 µM 2.9353911773112 0.000613362254495763 yes 24 0.00166563718250666 34 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_253 dyclonine 31.25 µM 2.91598957980992 0.000661105608573651 yes 25 0.00177281171182366 20 3180 An oral anasthetic.
SGTC_1032 k061-1018 98.7 µM 2.9005434977204 0.000701542005253292 yes 26 0.00186258066096333 16 4005393
SGTC_672 1441-0018 53.7 µM 2.87338194264116 0.000778223241843658 yes 27 0.0020305141279807 16 251141
SGTC_566 0958-0068 16.5 µM 2.85479190485075 0.000835076744962355 yes 28 0.00215325180157547 34 6815365
SGTC_2798 7813637 45.45 µM 2.81967140363102 0.000953036515569802 yes 29 0.00240364245847258 30 956368
SGTC_905 2-aminofluorene 215 µM 2.75583410061874 0.00120738460406581 no 30 0.0029271340902129 18 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2531 methyl deoxycholate 70.07 µM 2.74683139190939 0.00124787647422931 no 31 0.00300870302526062 20 16667744 Haematoxylin.
SGTC_1451 4152-0210 104 µM 2.74006022436773 0.00127914589774077 no 32 0.00307139636970521 17 659563
SGTC_2350 9023895 38.85 µM 2.7385988962296 0.00128598766548783 no 33 0.00308507999399242 22 2997209
SGTC_1756 st041558 35.5 µM 2.68272730475907 0.00157405850499268 no 34 0.00365122539039226 13 3955792
SGTC_2401 5128683 200 µM 2.68142710438274 0.00158141314675943 no 35 0.00366544421132228 29 708373
SGTC_155 k072-0202 43.6 µM 2.6802301036575 0.00158821171301841 no 36 0.00367857835392888 21 5857737
SGTC_1129 3453-1384 223 µM 2.67936479221184 0.00159314297196094 no 37 0.00368809929764349 34 1084452
SGTC_425 3825-7017 13.1 µM 2.66539597270513 0.00167470377264019 no 38 0.00384488593628227 28 3397440
SGTC_1714 st033236 13.627 µM 2.65980810985601 0.00170838145445505 no 39 0.00390925909462687 24 2916566
SGTC_1031 k035-0009 16 µM 2.6487092233957 0.00177710854682421 no 40 0.00403999091116804 16 5180959
SGTC_888 0916-0002 6.97 µM 2.63465603853475 0.00186773527906299 no 41 0.00421112911334622 18 2802138 YIL048W NEO1
SGTC_879 0831-1030 162 µM 2.61427225607462 0.00200666352392178 no 42 0.00447088758674298 45 1549252
SGTC_1273 0849-0096 14.1 µM 2.59892682770731 0.00211737113980158 no 43 0.00467578524261238 24 5286025
SGTC_1605 st000082 49.1 µM 2.57701333559257 0.00228507699088528 no 44 0.00498290528644042 22 1114022
SGTC_2806 7952793 58.44 µM 2.57003893345706 0.00234092360869142 no 45 0.0050843543025993 30 2972490
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 2.53781974822831 0.00261529265138633 no 46 0.00557727097560879 27 688662
SGTC_1317 1273-0028 910 nM 2.52484630407763 0.00273374300575891 no 47 0.00578744497043957 44 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_290 2043-6722 48.1 µM 2.52154110879671 0.00276468413410871 no 48 0.00584210110753348 20 773758 YLR208W SEC13
SGTC_2221 6807166 181.081 µM 2.4901965399486 0.00307420357501702 no 49 0.00638362358354193 8 674925
SGTC_780 0109-0199 192 µM 2.47724898199709 0.0032109192646421 no 50 0.00661997521694032 33 610414
SGTC_2418 pentamidine 31.67 µM 2.46327392554167 0.00336460164865806 no 51 0.00688373439917078 40 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1719 st032227 49.2 µM 2.45535342582633 0.0034546086765776 no 52 0.00703730683692441 33 3125804
SGTC_1292 0kpi-0043 232 µM 2.4467406824156 0.00355493189807602 no 53 0.0072077256972551 24 3333905
SGTC_2046 4110841 106 µM 2.43581784674392 0.0036859220187976 no 54 0.00742908225645443 40 44119630 YMR134W ERG29
SGTC_336 4111-0029 111 µM 2.43034983457843 0.00375310881086675 no 55 0.00754212765904202 15 3131175
SGTC_2246 7293507 91.5585 µM 2.42193236102245 0.00385868421052847 no 56 0.00771911188117283 44 887656
SGTC_1304 1165-0502 251 µM 2.41201009619563 0.00398654542624336 no 57 0.00793242110149412 33 767425
SGTC_2078 5212016 200 µM 2.40720799935775 0.00404977856878012 no 58 0.00803750574415068 16 1899708
SGTC_1305 1181-0477 144 µM 2.3632815396672 0.00467118812163753 no 59 0.009056951366541 37 6252086
SGTC_2162 5663267 200 µM 2.36326984078748 0.00467136437040452 no 60 0.00905723730420759 37 6456493
SGTC_1011 4112-3381 17.4 µM 2.358855166646 0.00473829845340635 no 61 0.00916570435110096 30 2877139
SGTC_1228 0124-0032 52.5 µM 2.35110150784732 0.00485793020126591 no 62 0.00935896339467836 25 X1228
SGTC_609 0986-0026 86.3 µM 2.33959960746013 0.00504035436509379 no 63 0.00965221155317157 41 2848610
SGTC_2454 5-benzylidenerhodanine 10.36 µM 2.32918390912135 0.00521078827715604 no 64 0.00992466248771717 45 1273210
SGTC_3300 9124615 50.48 µM 2.27595139798068 0.00616442031819455 no 65 0.0114244593532198 20 24824903
SGTC_2803 7707263 71.43 µM 2.26975622478882 0.00628488461265999 no 66 0.0116111889670455 31 2199229
SGTC_2591 skatole 100 µM 2.26870645898038 0.00630550239364256 no 67 0.0116430912825824 39 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1054 3429-0080 167 µM 2.25613198808055 0.00655716381050383 no 68 0.0120311831748367 27 1162877
SGTC_343 4130-2827 29.8 µM 2.2549546052485 0.00658117630737219 no 69 0.0120680891415149 30 1118244
SGTC_1270 0831-1170 17.3 µM 2.22509732976494 0.00721666375702395 no 70 0.0130373524870944 33 6764716
SGTC_2413 inermin 26.06 µM 2.22434214818591 0.00723341584598706 no 71 0.0130627164865532 71 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1567 st069303 68.4 µM 2.19631706913869 0.00787983756902461 no 72 0.0140346284158785 60 5581319
SGTC_2935 9038016 29.96 µM 2.19129723742403 0.00800084303867079 no 73 0.0142151449266964 42 6463195
SGTC_2644 guaiazulene 100 µM 2.17658046093409 0.00836506366326772 no 74 0.0147559421636142 19 3515 A coloring agent.
SGTC_1891 st059073 26.2 µM 2.16067809343297 0.00877491352052662 no 75 0.0153601071332418 37 688754
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 2.15688425732726 0.0088752542647182 no 76 0.0155073419244445 37 5377381
SGTC_2364 9055074 200 µM 2.15616408190979 0.0088944148626941 no 77 0.0155354275560928 30 6470630
SGTC_686 1319-0111 510 µM 2.14286373638057 0.00925485024891246 no 78 0.0160620208026743 53 4562600
SGTC_2354 9060492 162 µM 2.14139178489686 0.00929551474684204 no 79 0.0161212284350373 32 6471895
SGTC_808 0711-0032 135 µM 2.1306889663463 0.00959592309882208 no 80 0.0165573873363716 50 4252555
SGTC_973 1325-0077 65.9 µM 2.12317951557574 0.00981173338726017 no 81 0.0168694059118793 30 2835149
SGTC_1291 0993-0025 5.79 µM 2.12287735205949 0.00982050513047976 no 82 0.0168820653740104 34 4353356
SGTC_3021 9087658 49.47 µM 2.12252612819782 0.00983070969200743 no 83 0.0168967904803137 20 25237042
SGTC_3316 9136639 10.545 µM 2.11340303649198 0.010099038769024 no 84 0.0172831431473891 42 4903665
SGTC_558 k064-0027 21.3 µM 2.10725988653743 0.0102833020812931 no 85 0.0175475292038178 58 5088526
SGTC_1234 0326-0494 15.5 µM 2.09908450952737 0.010533064658116 no 86 0.0179047258519106 50 1547813
SGTC_598 3937-0236 20.2 µM 2.09670505581731 0.0106067443536639 no 87 0.0180098463419358 42 1379313
SGTC_887 0885-0007 9.62 µM 2.09586688559274 0.0106328049787718 no 88 0.0180470004870411 64 5719458
SGTC_381 3461-2219 42.7 µM 2.07832205748526 0.0111912600032761 no 89 0.0188398530910512 40 2883159
SGTC_751 0833-0568 350 µM 2.07615821494111 0.0112618716147574 no 90 0.0189396602284317 41 6954252
SGTC_368 fentichlor 4.58 µM 2.07548369778922 0.0112839618300065 no 91 0.018970864104263 46 7329 A pesticide.
SGTC_1347 1493-0251 600 nM 2.06517497198822 0.0116262848369699 no 92 0.019453223862107 42 3986378
SGTC_3042 9091578 49.47 µM 2.04042055012027 0.0124853429292775 no 93 0.0206542284151505 30 25236497
SGTC_2143 5623677 140.463 µM 2.03244908756848 0.0127734344712987 no 94 0.0210541064851091 38 5375313
SGTC_740 k014-0057 261 µM 2.02737841291928 0.0129596681299472 no 95 0.021311863940617 56 4012779
SGTC_2667 digitoxin 100 µM 2.0265697956108 0.0129895827086345 no 96 0.0213532140598214 22 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_356 1634-0012 32.5 µM 2.02513703508555 0.013042733914352 no 97 0.0214266474692693 52 735457
SGTC_2172 5754775 163.918 µM 2.02036831238562 0.0132209959225225 no 98 0.0216725988745189 65 2263357
SGTC_512 prima-1 270 µM 2.01487167515036 0.0134290763383754 no 99 0.0219590482685377 39 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2001 4023502 57.655 µM 2.01256394098272 0.0135172770629251 no 100 0.0220802618204431 48 108941 YCR052W RSC6
SGTC_1829 berberine 14.4 µM 2.00900058713904 0.0136544491974249 no 101 0.0222685357343666 61 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1851 st056236 18.9 µM 2.00296983920595 0.0138893414265041 no 102 0.0225902629496472 50 5393171
SGTC_1041 0206-0046 107 µM 1.98635960850668 0.0145543894791564 no 103 0.0234967041103428 52 50494
SGTC_60 0986-0278 202 µM 1.98625090541258 0.0145588305095852 no 104 0.0235027354999893 42 3110598
SGTC_2099 5377090 177.372 µM 1.98126602773516 0.0147637429326878 no 105 0.0237807240214246 62 2243829
SGTC_1262 0737-0114 49.6 µM 1.97342823877878 0.0150909451621146 no 106 0.0242233964798191 53 765919
SGTC_2256 7954252 200 µM 1.97278033639522 0.0151182697105655 no 107 0.0242602972083747 61 2972920
SGTC_1223 0764-0573 147 µM 1.96134804355106 0.0156074526657831 no 108 0.0249192182184382 34 1609797
SGTC_789 1309-1135 70.6 µM 1.93875467596517 0.0166142551151206 no 109 0.0262656087293636 47 3092424
SGTC_3218 9131285 49.47 µM 1.92977405269819 0.017029615618288 no 110 0.026817419912673 62 17156417
SGTC_935 2996-0153 430 µM 1.92917422979966 0.0170576713567508 no 111 0.0268546181255535 47 23738523
SGTC_1089 terbinafine 2.25 µM 1.92337385219198 0.0173310187321666 no 112 0.0272165578624192 49 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_562 3772-2733 112 µM 1.91963071277606 0.0175093962927084 no 113 0.0274522808848459 53 2876874 YIL048W NEO1
SGTC_2894 9048625 32.47 µM 1.9065440557128 0.0181454049941123 no 114 0.0282898277518004 71 4092861
SGTC_1266 0828-0227 32.9 µM 1.90602378183764 0.0181710919633205 no 115 0.0283235601134504 64 3913820
SGTC_2133 5320837 200 µM 1.90071761497984 0.0184348425862666 no 116 0.028669505014604 41 2841355
SGTC_3319 9138450 16.7555 µM 1.8991486941314 0.0185134498792823 no 117 0.0287724641373477 51 2029690
SGTC_2307 7538926 6.34 µM 1.898334830718 0.0185543390058453 no 118 0.0288259942288419 87 96582
SGTC_287 k060-0039 29.6 µM 1.89833174958669 0.0185544939502423 no 119 0.0288261970407407 67 5861974
SGTC_3314 9135860 59.4275 µM 1.89471889766509 0.0187369372207189 no 120 0.0290648263815832 40 25252478
SGTC_653 0203-0016 55.2 µM 1.88915487430122 0.0190208967193877 no 121 0.0294355396698555 56 295302
SGTC_2815 7968870 71.43 µM 1.88543711923975 0.0192126648677075 no 122 0.0296854232523753 63 2977326 YHR190W ERG9
SGTC_2953 9074162 66.49 µM 1.88309802598081 0.0193341595993976 no 123 0.029843542351771 52 16451992
SGTC_746 1095-0025 46.6 µM 1.88266800895509 0.0193565659890737 no 124 0.0298726867306621 62 6749286
SGTC_1405 3909-7894 12 µM 1.88064424087406 0.0194623125729791 no 125 0.0300101646686886 45 7104060
SGTC_907 3448-6986 75.5 µM 1.86087901164211 0.0205211398021337 no 126 0.0313806321639325 62 590582
SGTC_1906 st060206 94.7 µM 1.86051508836169 0.020541084026891 no 127 0.0314063428781792 63 5133468
SGTC_14 0354-0009 295 µM 1.85711497778416 0.0207282162851713 no 128 0.0316473988654279 56 1713507
SGTC_27 0485-0001 32.618 µM 1.85387384902671 0.0209079406405463 no 129 0.0318786050085402 49 2054479
SGTC_2767 sibutramine 71.45 µM 1.84091292111012 0.0216398784797573 no 130 0.0328171602928701 43 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2809 7964133 12.99 µM 1.83891991417533 0.0217543273024534 no 131 0.0329634831381358 75 1253665
SGTC_943 3253-1379 105 µM 1.83474479974166 0.0219957422797398 no 132 0.0332717554998258 68 668464
SGTC_843 0310-0051 143 µM 1.82964108287362 0.0222939198401571 no 133 0.0336518131258569 56 2065037
SGTC_2852 9023854 51.95 µM 1.82956801219181 0.022298213532722 no 134 0.0336572803022458 74 19798528
SGTC_1619 st003326 88.7 µM 1.82623527071606 0.0224947909964751 no 135 0.0339074153230195 52 2849032
SGTC_1675 st018485 24.5 µM 1.82541325114816 0.0225435008096977 no 136 0.0339693455646492 75 3323024
SGTC_74 000s-0487 160.283 µM 1.82231413919108 0.0227279430307267 no 137 0.0342036670150937 52 677548
SGTC_1552 6-methylflavone 10.6 µM 1.82116064023737 0.022796916998774 no 138 0.0342912207928382 61 689013
SGTC_1612 st002233 45.4 µM 1.79751784790177 0.0242499722705781 no 139 0.0361267236411597 58 1035021
SGTC_3262 9137218 49.47 µM 1.79659312606114 0.0243083499351287 no 140 0.0362001182375347 37 17650664
SGTC_2794 7785382 27.27 µM 1.78280149486635 0.0251931119954771 no 141 0.0373093111753001 81 2205081
SGTC_2115 tiliquinol 12.7705 µM 1.7792507667868 0.025425217692862 no 142 0.0375993293297994 69 71208 A bioactive hydroxyquinoline.
SGTC_1746 st038117 42 µM 1.77656298079838 0.0256021028873155 no 143 0.0378200854960747 75 2898218
SGTC_2352 9027995 87.8 µM 1.77610809143153 0.0256321412013923 no 144 0.0378575514174533 55 2997347
SGTC_2520 obtusaquinone 4.71 µM 1.77141570640352 0.0259437252104962 no 145 0.038245799322347 68 5967872
SGTC_3105 9121040 49.47 µM 1.76936304579342 0.0260810189861386 no 146 0.0384166542225074 42 41448907
SGTC_1621 st003705 32.4 µM 1.76495688703048 0.0263777811780863 no 147 0.0387855058872468 73 24207032
SGTC_1653 st012112 65 µM 1.76320453491803 0.0264965868853238 no 148 0.0389329996057313 47 720429
SGTC_2286 7945697 125 µM 1.7583520555653 0.0268279099293438 no 149 0.0393438127543998 63 1245733
SGTC_1395 3486-0190 4.35 µM 1.75807579726856 0.0268468762177356 no 150 0.0393673066271647 66 6748079
SGTC_612 0302-0167 22.4 µM 1.7580229878536 0.0268505030793806 no 151 0.0393717990048917 76 235821
SGTC_1191 1487-1166 10.6 µM 1.75256709747574 0.027227414912842 no 152 0.0398381715705288 49 3955771
SGTC_3211 9128781 49.47 µM 1.74721313728568 0.0276015657421134 no 153 0.0403001868702288 77 17194361
SGTC_279 1273-0055 2.93 µM 1.74696305736766 0.0276191463295006 no 154 0.0403218732326065 75 2847562
SGTC_1419 3993-2473 62.6 µM 1.74589752787094 0.0276941575587133 no 155 0.0404143797698473 59 704026
SGTC_109 0132-0036 33.701 µM 1.74521039256079 0.0277426205516528 no 156 0.040474126437866 69 67274 A color developer.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.74513595023406 0.0277478751375668 no 157 0.0404806035286467 85 5393153
SGTC_3313 9133968 57.047 µM 1.73284728118419 0.0286267221528781 no 158 0.0415614082814078 49 1494643
SGTC_2489 cantharidin 73.42 µM 1.73249263502124 0.0286524251411618 no 159 0.0415929436413395 79 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1200 1643-0193 18.4 µM 1.72419224668531 0.0292594985041805 no 160 0.0423365716749736 76 5403974
SGTC_2716 st080858 38.6235 µM 1.72199205002765 0.0294221956825934 no 161 0.0425354793183365 54 5296050
SGTC_2685 mycophenolic acid 18.85 µM 1.71971408021762 0.0295914346327994 no 162 0.0427422135671026 49 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1053 3366-3204 134 µM 1.70759848428843 0.0305051776163528 no 163 0.0438554349142667 85 3632071 YPR165W RHO1
SGTC_1237 0330-0133 46.1 µM 1.70604497666346 0.0306240141220185 no 164 0.0439998529451748 92 X1237 YHR072W ERG7
SGTC_2034 5197015 53.07 µM 1.70483083619557 0.0307171572165374 no 165 0.0441129893292049 79 780676
SGTC_1854 st056233 32.9 µM 1.70219964029029 0.0309198152021066 no 166 0.0443589750947553 77 5393174
SGTC_1243 0416-0003 5.65 µM 1.6996277415245 0.0311189742708044 no 167 0.0446004844042712 77 2141977
SGTC_426 0988-0037 14.6 µM 1.69034726956075 0.0318464654928117 no 168 0.0454807683745098 90 5383008
SGTC_2022 5136654 200 µM 1.68719447628425 0.0320967858676885 no 169 0.0457829815950498 93 1713771
SGTC_3253 9135987 49.47 µM 1.686231528381 0.0321735635042748 no 170 0.0458756067238249 81 4182430
SGTC_141 0443-0274 32.331 µM 1.67829722355082 0.0328119683820923 no 171 0.0466445449012014 65 1627241
SGTC_185 k048-0037 25.491 µM 1.66945996521628 0.0335352821195402 no 172 0.0475131290928564 52 6827589
SGTC_2670 beta-carotene 100 µM 1.66549401691309 0.0338641283813871 no 173 0.0479071181557606 39 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2491 paeonol 100 µM 1.66450821038491 0.0339462792668933 no 174 0.0480054558387807 59 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2466 5983409 37.09 µM 1.66297264106519 0.0340745703659799 no 175 0.0481589560621171 82 2879657
SGTC_264 promethazine 12.5 mM 1.65631489838105 0.0346354193423164 no 176 0.0488290324754223 114 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1081 sertraline 6 µM 1.6546709334673 0.0347750682001031 no 177 0.0489956331033595 77 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_572 0960-0087 17.7 µM 1.6532342779934 0.0348974851115884 no 178 0.0491415963870727 111 6796365
SGTC_2919 7978188 46.38 µM 1.65255440217974 0.0349555402866931 no 179 0.0492107923004005 68 2980291
SGTC_2473 5854593 8.94 µM 1.64922130448676 0.0352413043655262 no 180 0.0495511524437168 79 2872951
SGTC_1997 st073024 93.8 µM 1.64862242441699 0.035292852062248 no 181 0.0496125058809129 66 686268
SGTC_2257 7960413 200 µM 1.63706746111967 0.0362995944402849 no 182 0.0508081872815915 92 2974689 YIL048W NEO1
SGTC_1988 st071872 53.4 µM 1.62710178365261 0.0371866375796044 no 183 0.0518577411430351 57 16414116
SGTC_180 1486-1293 102.781 µM 1.62681453285795 0.0372124660429457 no 184 0.0518882470620624 92 4140536
SGTC_2196 6573537 42.6665 µM 1.6264875743848 0.0372418827004715 no 185 0.0519229872725044 82 2903087
SGTC_130 0136-0219 337.655 µM 1.61592402169867 0.0382025610625113 no 186 0.053055370619375 92 234244
SGTC_2770 toltrazuril 17.5 µM 1.6144496775962 0.0383382349786015 no 187 0.0532149618641886 68 68591 Kills coccidiodes.
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.60886281414998 0.0388559251249112 no 188 0.053823171078166 52 6708630 An antioxidant.
SGTC_294 k038-0071 157 µM 1.60463363735639 0.0392515836853275 no 189 0.0542872271348192 103 24152826
SGTC_266 formosanin C 406 nM 1.60055565698076 0.039636196098173 no 190 0.0547376851563699 111 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1088 bifonazole 369 nM 1.59830974565232 0.0398493232400516 no 191 0.0549870297789513 68 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2181 6316240 54.2555 µM 1.59354893740158 0.040304183609902 no 192 0.0555185495680113 68 12779990
SGTC_1871 st057448 67.3 µM 1.59324501965432 0.0403333633266285 no 193 0.0555526176728193 86 691747
SGTC_791 1348-1292 225 µM 1.58966754246483 0.0406781348947741 no 194 0.0559548817865386 80 5437054
SGTC_2765 myclobutanil 7.74 µM 1.58783030546306 0.04085612197636 no 195 0.0561623583118014 101 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1091 telmisartan 47.6 µM 1.57450594748589 0.0421659382411098 no 196 0.0576852638195046 99 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_415 dibenzyl ketone 100 µM 1.56606656818996 0.0430129844864477 no 197 0.0586665168845368 96 7593
SGTC_556 4058-0063 51.5 µM 1.56263565107132 0.0433612470478946 no 198 0.0590691588989399 86 6615692
SGTC_561 1550-0330 72.9 µM 1.56233735762639 0.0433916332273378 no 199 0.0591042678863937 85 6812934
SGTC_452 diindolylmethane 8 µM 1.55945442228898 0.0436861952506517 no 200 0.0594444320186449 71 3071 Inhibits expression of several cancer promoting factors.
SGTC_2373 9071805 200 µM 1.55701916383109 0.0439362714163555 no 201 0.0597329677818407 79 10149009
SGTC_1636 st007707 68.9 µM 1.5543012984812 0.0442167303677483 no 202 0.0600562819734319 83 403051
SGTC_2443 5493264 126.67 µM 1.55326379475013 0.0443241711551131 no 203 0.0601800630232321 77 5340055
SGTC_3266 9136860 49.47 µM 1.55134546802827 0.0445233814405798 no 204 0.0604094580292353 106 4871271 YPR165W RHO1
SGTC_354 2783-3500 4.88 µM 1.5433702561453 0.0453593192839388 no 205 0.0613704830847477 125 6740761
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.53525036270131 0.0462233453411104 no 206 0.0623611708606496 55 4000243
SGTC_2469 5655019 90.81 µM 1.53492810813911 0.0462579067876937 no 207 0.0624007441267331 78 2788239
SGTC_1701 st028638 40.4 µM 1.53048765596876 0.0467362564942039 no 208 0.062948033313095 74 3490878
SGTC_2220 6782180 200 µM 1.53028223368218 0.0467584813854012 no 209 0.0629734419772519 53 833803
SGTC_687 k029-0044 34.9 µM 1.52811497784192 0.046993476426159 no 210 0.0632419966718111 58 5829338
SGTC_3354 9151612 71.43 µM 1.51730426109558 0.0481798585931839 no 211 0.0645949414431192 84 27261949
SGTC_147 4466-0538 29.23 µM 1.51594869436807 0.0483302963974936 no 212 0.0647661630261422 95 6742687 YHR072W ERG7
SGTC_1649 st011737 51.3 µM 1.5147620946154 0.0484622908071401 no 213 0.064916331481912 86 1761035
SGTC_900 1112-0045 141 µM 1.51446204975173 0.0484957126754598 no 214 0.0649543460180343 87 56211 YIL048W NEO1
SGTC_732 3970-1727 52.7 µM 1.51102353836377 0.0488800443181086 no 215 0.0653912269284173 93 1275699
SGTC_3244 9134489 49.47 µM 1.50516558672413 0.0495404048056835 no 216 0.0661407551389748 103 16584271
SGTC_2659 sanguinarine 24.21 µM 1.50332915954261 0.0497488829196326 no 217 0.066377092145045 91 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.50262877269407 0.0498285776035523 no 218 0.066467399727762 106 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.50200041205205 0.0499001633007201 no 219 0.06654850120635 72 77254
SGTC_880 0833-0487 87.2 µM 1.50006893824554 0.0501207192376044 no 220 0.0667982730146845 95 76075
SGTC_416 estradiol valerate 100 µM 1.49781476965756 0.0503791058976735 no 221 0.067090691187605 105 13791 A steroid.
SGTC_2669 eugenol 100 µM 1.49509217777222 0.0506926001426517 no 222 0.0674451935303987 54 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3119 9125183 49.47 µM 1.49418502143893 0.0507973995222121 no 223 0.0675636332381452 64 22695334
SGTC_375 3970-0961 9.27 µM 1.49345136065214 0.0508822819182721 no 224 0.0676595385988204 95 2898222
SGTC_1181 1222-0449 220 µM 1.49003390734018 0.0512791602943203 no 225 0.068107660334557 99 658318
SGTC_1098 clofazimine 15.1 µM 1.49003093649894 0.0512795063746825 no 226 0.0681080508875216 126 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_956 1185-0240 191 µM 1.48690101403102 0.0516451519165738 no 227 0.0685204782073065 87 1416193
SGTC_858 0438-0351 2.77 µM 1.48205276808165 0.0522156251328323 no 228 0.0691631274564735 101 2799119
SGTC_1618 st003135 44.5 µM 1.47685948280394 0.0528322372947405 no 229 0.0698566538978997 105 1270615
SGTC_739 1486-1183 203 µM 1.47504186933002 0.0530494068596468 no 230 0.0701006436125787 86 4346692
SGTC_623 k072-0108 16.9 µM 1.45256852741107 0.0557934131521755 no 231 0.0731717948489825 117 5382803
SGTC_2310 7668677 200 µM 1.45053241428029 0.0560474574398347 no 232 0.0734550534357655 136 2197143
SGTC_362 0310-0100 9.03 µM 1.44549706268991 0.0566796326294132 no 233 0.074159158733768 87 790235
SGTC_2625 euphol 100 µM 1.44126520463998 0.0572152639967097 no 234 0.0747548867162034 122 6708538 A triterpene alcohol.
SGTC_564 3555-0129 330 µM 1.43952554532176 0.0574366068982489 no 235 0.0750008388067515 93 563260
SGTC_2436 5633522 8.09 µM 1.43274022291425 0.058306370871488 no 236 0.0759660450126739 107 5724242
SGTC_1771 st048882 4.1505 µM 1.4266106452551 0.0591009427860945 no 237 0.0768460770447495 112 4580403
SGTC_942 3253-1115 227 µM 1.42506893866313 0.0593021236504461 no 238 0.0770686371656425 120 46497897
SGTC_3004 9076122 71.4286 µM 1.42190798255694 0.0597162829059983 no 239 0.0775264827711463 103 44782551
SGTC_107 0358-0022 2.6945 µM 1.42114873750236 0.0598160985457058 no 240 0.0776367618951207 91 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1708 st033234 31.827 µM 1.42056068369246 0.0598934979717703 no 241 0.0777222575781941 112 674664
SGTC_143 4032-1194 15.74 µM 1.41980492025967 0.0599930864435591 no 242 0.0778322410725375 136 1806963
SGTC_474 dl-dihydrosphingosine 5 µM 1.41852827496954 0.0601616070549957 no 243 0.078018294833449 109 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2805 7950783 58.44 µM 1.41613630006434 0.060478351620511 no 244 0.0783678009018292 111 1178958 YDL195W SEC31
SGTC_3269 9137823 49.47 µM 1.41250378147319 0.0609618621494367 no 245 0.0789008390218437 75 17682936
SGTC_1508 1080-0625 72.9 µM 1.40805644752672 0.0615579383459152 no 246 0.0795571779823235 110 767111
SGTC_317 4495-0002 170 µM 1.40640022834455 0.0617810810078578 no 247 0.0798026562606156 97 15991618
SGTC_1079 idarubicin 2.36 µM 1.40220059912878 0.0623497282950182 no 248 0.0804276764008156 118 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3090 9117696 49.47 µM 1.40163988631497 0.0624259590171872 no 249 0.0805114049619989 89 7923821
SGTC_1379 2144-0755 36.5 µM 1.39771409785087 0.0629617199724437 no 250 0.0810994695199 119 5392327
SGTC_1271 0832-2808 169 µM 1.39654712350643 0.0631216682237627 no 251 0.0812749002381234 130 3663794
SGTC_729 4092-0585 94.1 µM 1.39534770357949 0.0632863931232087 no 252 0.0814555066706093 107 2169061
SGTC_786 4544-0069 423 µM 1.38790746447521 0.0643157021086095 no 253 0.082582612288748 130 748821 YLR208W SEC13
SGTC_924 2046-0044 21.3 µM 1.3877931894111 0.0643316121686872 no 254 0.082600014644542 121 3623589
SGTC_2066 5222451 176 µM 1.38681964095577 0.0644672794730394 no 255 0.0827483832205628 143 2281147
SGTC_884 0851-0618 334 µM 1.38191201023061 0.065154561718105 no 256 0.0834993598864772 111 9642473
SGTC_2891 9063876 19.48 µM 1.3816359398618 0.0651933918722515 no 257 0.0835417564624359 84 6472478
SGTC_176 1486-1328 72.834 µM 1.37867426442225 0.0656110911171009 no 258 0.083997603887135 130 22310231
SGTC_1734 st037168 69.4 µM 1.37340647064565 0.0663591572501691 no 259 0.0848130096590574 116 708907
SGTC_2289 7946404 165.07 µM 1.37173527463816 0.0665978544822301 no 260 0.0850729315043196 140 1246120 YPR165W RHO1
SGTC_1750 st081859 2.357 µM 1.37054054382315 0.0667689050839792 no 261 0.0852591141421297 149 5291695
SGTC_333 3486-0131 40.1 µM 1.36880450251043 0.0670180611729214 no 262 0.0855301965489954 115 6744690
SGTC_59 0330-0160 1.33 µM 1.36820368172361 0.0671044580811463 no 263 0.085624164751448 106 4293482
SGTC_1615 st002656 86.5 µM 1.36797569342147 0.0671372649074165 no 264 0.0856598422819634 104 1584458
SGTC_872 0588-0139 234 µM 1.36419574744817 0.0676829968798947 no 265 0.0862529831251658 100 2047100
SGTC_2941 9056145 11.23 µM 1.36208625694277 0.0679890422543849 no 266 0.0865853324704922 108 2119517
SGTC_1185 1319-0113 81.3 µM 1.35758133473332 0.0686461937351478 no 267 0.0872982844804731 118 4672763
SGTC_1261 0712-0010 12.7 µM 1.3574058754053 0.0686718874722929 no 268 0.08732614120217 112 2840123
SGTC_1847 st056231 15 µM 1.35293692580451 0.0693288101104671 no 269 0.0880378907363767 116 5393180
SGTC_1282 0886-0010 32.4 µM 1.34821248425007 0.0700285419582275 no 270 0.0887950251962193 135 2836211 YNL267W PIK1
SGTC_116 0155-0182 31.788 µM 1.34468250700559 0.0705549000865153 no 271 0.0893638930494117 112 771486
SGTC_1659 st012954 42.1 µM 1.34448727662515 0.0705840995706578 no 272 0.089395434024653 103 24207262
SGTC_2640 pentamidine 10.38 µM 1.34394247556209 0.0706656314536735 no 273 0.0894834946380822 130 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_796 1234-0020 70.7 µM 1.34027049940638 0.0712170479519535 no 274 0.0900787093871577 113 46495034
SGTC_1398 3558-0053 112 µM 1.33687304192384 0.0717301770297479 no 275 0.0906320408911272 92 4532369
SGTC_90 0870-0863 4.608 µM 1.33612462366884 0.0718435933276644 no 276 0.0907542714277734 131 1738164
SGTC_1475 4092-1048 11.7 µM 1.33291022772199 0.0723322715001267 no 277 0.0912806328842669 122 2881759
SGTC_1553 gossypol 38.6 µM 1.33258643623457 0.0723816377368049 no 278 0.0913337793795896 104 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3207 9114163 49.47 µM 1.33153853395223 0.0725415810840695 no 279 0.0915059372468242 149 849233
SGTC_1272 0839-0021 27 µM 1.32998764577275 0.0727787927786365 no 280 0.0917611708988823 125 5027250
SGTC_995 3931-2021 34.6 µM 1.32395159509057 0.0737076765650353 no 281 0.0927595605694232 118 730143
SGTC_2104 5389443 200 µM 1.32376737019308 0.0737361686711705 no 282 0.0927901580228189 122 2244536
SGTC_1137 ixabepilone 100 µM 1.32304698533493 0.0738476637681006 no 283 0.0929098766000025 124 154225 A novel microtubule stabilizer.
SGTC_113 0099-0221 2.5 µM 1.32152989247204 0.0740828879365971 no 284 0.0931623710764549 123 89219
SGTC_2142 5622915 118.518 µM 1.32068949414265 0.0742134372213912 no 285 0.0933024592532989 93 5322196
SGTC_2324 6149169 200 µM 1.32012916341888 0.0743005777829652 no 286 0.0933959486725055 127 2888231
SGTC_938 3126-1755 342 µM 1.31861546559363 0.0745363731066373 no 287 0.0936488503312192 107 1777771
SGTC_1875 nocodazole 6 µM 1.31706821887559 0.0747779843764126 no 288 0.0939078794023566 120 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_492 tmb-8 126 µM 1.31674818071201 0.0748280346369789 no 289 0.0939615238577734 104 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1101 ebselen 5.29 µM 1.31421814244029 0.0752246033653593 no 290 0.0943864024217193 143 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1500 4488-1866 171 µM 1.31347679743291 0.0753411078842045 no 291 0.094511167177474 125 2900003
SGTC_621 3584-0052 32.1 µM 1.31342110166901 0.0753498661866425 no 292 0.0945205454116136 130 2273927
SGTC_3200 9114385 49.47 µM 1.31131530915865 0.0756815771582021 no 293 0.0948756291383779 117 17018030 YLR208W SEC13
SGTC_725 1497-0963 19 µM 1.31078680590999 0.0757650030061569 no 294 0.0949649007010167 109 3549977
SGTC_897 1000-0139 31.4 µM 1.30725047114624 0.0763250276544662 no 295 0.0955638296846438 118 6151020
SGTC_1188 1403-0014 4.57 µM 1.3055666351131 0.0765927895058553 no 296 0.0958499864293226 117 9614867
SGTC_196 k015-0023 18.111 µM 1.30534424967646 0.0766282063515485 no 297 0.0958878264234775 91 5211998
SGTC_2678 equilin 100 µM 1.30475910226766 0.0767214557486837 no 298 0.0959874446688907 105 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1974 st069448 26.9 µM 1.30011178236516 0.0774651216344987 no 299 0.096781329990896 108 6323587 YNR016C ACC1
SGTC_52 0329-0193 875 nM 1.29834717451007 0.077748924365395 no 300 0.0970840313492563 123 3739292
SGTC_219 mitoxanthrone 164.414 µM 1.29444283296897 0.0783796655698211 no 301 0.097756251790886 129 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2761 levamisole 97.89 µM 1.29306003313285 0.0786039830036191 no 302 0.0979951483675748 96 26879 An alkaline phosphatase inhibitor.
SGTC_2393 9031399 185.94 µM 1.2925516065409 0.0786865820642127 no 303 0.0980830931260917 143 1526623 YDL150W RPC53
SGTC_2860 9025725 38.96 µM 1.29087054394171 0.0789601560597448 no 304 0.0983742855113721 130 40546248
SGTC_344 k064-0035 6.43 µM 1.28825170896542 0.0793877765020209 no 305 0.0988291786536085 121 5088750
SGTC_301 4119-0100 24.5 µM 1.28379940113505 0.0801187981914123 no 306 0.0996060765987681 124 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_251 melphalan 456.522 µM 1.2799509680361 0.0807547603373238 no 307 0.100281190369866 147 460612 A DNA alkylator.
SGTC_2223 6903751 107.57 µM 1.27836784012069 0.0810174795412957 no 308 0.100559878963058 119 5598863
SGTC_2701 st077767 14.721 µM 1.27650407547867 0.0813275964164052 no 309 0.100888693530597 128 5721188
SGTC_2959 9079155 11 µM 1.27636861825183 0.0813501703711825 no 310 0.100912622085578 141 16189457
SGTC_367 0335-0881 7.1 µM 1.27547594800273 0.0814990521403918 no 311 0.101070416009402 144 23828853
SGTC_1561 5-methoxyflavone 52.9 µM 1.2750693038662 0.0815669413459193 no 312 0.101142356537671 118 94525
SGTC_2219 9098279 200 µM 1.27381271197517 0.0817769987449755 no 313 0.101364899473581 88 902349
SGTC_1903 st060211 78.3 µM 1.2733198930559 0.0818594917362138 no 314 0.101452275217315 128 688960
SGTC_749 1000-0129 128 µM 1.27062692252004 0.0823113762747634 no 315 0.101930702213019 120 708470
SGTC_2522 biochanin a 4.94 µM 1.27005038100117 0.082408364495376 no 316 0.102033342312158 120 5280373 A possible chelator.
SGTC_439 amiodarone 34.4 µM 1.26964282631392 0.0824769769407331 no 317 0.102105943508348 123 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2237 6667747 47.222 µM 1.26845428269613 0.0826773156374126 no 318 0.102317883541437 116 729940 YDL015C TSC13
SGTC_1458 k015-0034 6.33 µM 1.26805461343556 0.0827447653590112 no 319 0.102389224039028 112 3598957
SGTC_493 zm226600 134 µM 1.26632294016053 0.0830374876336315 no 320 0.102698743594903 135 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.2658719484085 0.0831138510204796 no 321 0.102779465433547 126 688751
SGTC_163 TUB2.036 7.546 µM 1.2651121596082 0.0832426203373357 no 322 0.10291556230363 175 15992207 YJR013W GPI14
SGTC_891 0929-0073 133 µM 1.25930270093918 0.084232172059541 no 323 0.103960509021725 145 5603632
SGTC_2295 7971645 200 µM 1.25777623341582 0.0844936411637793 no 324 0.104236346615723 115 2978226 YKL099C UTP11
SGTC_398 bronopol 33.3 µM 1.25186711562914 0.0855115582789759 no 325 0.105309144553737 147 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_649 1123-0311 367 µM 1.25067389440529 0.0857182149596056 no 326 0.105526739306775 151 693629 YIL048W NEO1
SGTC_500 h-89 112 µM 1.24976681203684 0.0858755645819743 no 327 0.105692371442668 146 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_821 1114-0266 29.2 µM 1.24643296713194 0.0864557369732695 no 328 0.106302742217986 131 3123235
SGTC_1527 coumarin 137 µM 1.24633131638077 0.0864734726727585 no 329 0.106321392666135 149 323 A hepatotoxic, DNA x-linker.
SGTC_3080 9117754 49.47 µM 1.24483505442442 0.0867348504869525 no 330 0.106596193894419 147 9550191
SGTC_1955 wogonin 32.4 µM 1.23532031659432 0.088410782596367 no 331 0.108355657704681 100 5281703 A flavanone.
SGTC_2595 hexamethylquercetagetin 100 µM 1.23391858167501 0.0886597106852158 no 332 0.108616622338126 155 386331
SGTC_1070 indatraline 8.81 µM 1.23302070623503 0.0888194345832956 no 333 0.108784019491579 152 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1693 xanthone 101.9 µM 1.23262322404051 0.0888902114415086 no 334 0.108858184066617 162 7020 An insecticide.
SGTC_1143 3454-2408 5.08 µM 1.23087410377519 0.0892021639724963 no 335 0.109184977210166 111 X1143
SGTC_2742 clothiapine 36.27 µM 1.23037672384514 0.0892910193941804 no 336 0.109278032720311 91 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2648 atorvastatin 78.68 µM 1.23021454129117 0.0893200070495232 no 337 0.109308387997278 135 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2251 lansoprazole 556 µM 1.22818148211482 0.0896839794931626 no 338 0.109689424279644 123 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_65 0798-0905 34.986 µM 1.2277179271541 0.0897671224993453 no 339 0.109776437162662 143 3602145
SGTC_563 tetrahydrosecaminediol 614 µM 1.22655362482332 0.089976203905745 no 340 0.109995204267981 126 334274 A psychoactive constituent of the cannabis plant.
SGTC_3165 9101544 49.47 µM 1.22514485232822 0.0902296699913404 no 341 0.110260324217656 140 5002184
SGTC_3039 9090270 49.47 µM 1.22349103940809 0.0905279000076362 no 342 0.110572143273085 114 17173750
SGTC_2277 7947813 106.88 µM 1.22275180091339 0.0906614423700251 no 343 0.110711727621823 132 1246798
SGTC_1183 1254-0324 198 µM 1.22208185272776 0.0907825937870424 no 344 0.110838337483283 114 5799357
SGTC_513 4245-1575 41.7 µM 1.22112334163847 0.0909561368925401 no 345 0.111019661606308 169 719745
SGTC_658 3253-0951 102 µM 1.22012381755839 0.0911373675993807 no 346 0.111208970449327 153 1184878
SGTC_534 k292-0788 63.4 µM 1.21973832341996 0.0912073357518847 no 347 0.111282044370618 172 4146317
SGTC_716 1683-5115 658 µM 1.21903882914478 0.0913343974139442 no 348 0.111414727637581 152 723597
SGTC_862 0452-0056 10.2 µM 1.2189647631615 0.0913478590231523 no 349 0.111428783437824 119 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1340 1486-1359 257 µM 1.21373303744023 0.0923024587365385 no 350 0.112424842104839 144 4309068
SGTC_600 1495-0418 41.6 µM 1.20976265244135 0.0930318226037938 no 351 0.113184990522474 158 5377768
SGTC_3055 9094636 49.47 µM 1.20870766200192 0.0932263399120715 no 352 0.113387588506088 170 25236176
SGTC_624 k048-0052 28 µM 1.20793179812925 0.0933695840067987 no 353 0.113536748613629 127 6835531
SGTC_72 0744-0168 198.391 µM 1.20281774910764 0.0943178367533401 no 354 0.114523427387605 143 677577
SGTC_1388 3346-4487 254 µM 1.19763609744583 0.0952858492744326 no 355 0.115529358391819 149 3345614
SGTC_705 1124-0212 310 µM 1.19661697266419 0.0954770952951876 no 356 0.115727940964278 165 9554485
SGTC_1275 0867-0008 21.1 µM 1.19567943478807 0.0956532803147274 no 357 0.115910839834465 131 3422836
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.19359503988832 0.0960458431792197 no 358 0.116318207590877 145 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2839 9003951 25.97 µM 1.19307001554028 0.0961449097366878 no 359 0.116420976703761 117 2990634
SGTC_2551 apiole 73.87 µM 1.19220572674717 0.0963081555015955 no 360 0.116590294245708 118 10659 A possible DNA adduct former.
SGTC_250 brefeldin a 552.239 µM 1.18894384773462 0.0969260903061947 no 361 0.117230882039332 122 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_532 1548-0774 215 µM 1.18859406988102 0.0969925251096025 no 362 0.117299721277128 153 5932993
SGTC_3084 9116877 49.47 µM 1.18836472513525 0.0970361036783965 no 363 0.117344873799289 112 27241325
SGTC_817 1391-0715 46 µM 1.1873253826999 0.0972337727933953 no 364 0.117549649874829 169 1353946
SGTC_1665 st014639 11.4 µM 1.18599492373233 0.0974872393867354 no 365 0.11781215210749 146 981133 YIL048W NEO1
SGTC_2898 9056270 58.44 µM 1.18597727680394 0.097490604567842 no 366 0.117815636667177 101 19154699
SGTC_670 4204-0025 119 µM 1.18560611786495 0.0975614024655333 no 367 0.117888942550718 127 719039
SGTC_2254 7938975 95.19 µM 1.18416106899605 0.0978374020950564 no 368 0.118174654849509 138 2969277
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.18388715988955 0.0978897823032064 no 369 0.118228866792769 156 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_567 1080-0542 68.4 µM 1.17962018122537 0.0987084212263549 no 370 0.119075656328425 121 5950415
SGTC_1248 0469-0687 58.6 µM 1.17620082257233 0.0993680482636829 no 371 0.119757317940298 146 4017482
SGTC_443 clozapine 122 µM 1.17412741487776 0.0997695946913204 no 372 0.12017199703032 138 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_986 1493-0483 84 µM 1.17374645343538 0.0998435023042364 no 373 0.120248298765174 148 40079
SGTC_798 1287-0182 476 µM 1.17304956327058 0.0999788044699954 no 374 0.120387965322304 144 1649755
SGTC_8 0354-0001 70 µM 1.17254507427434 0.100076835204932 no 375 0.120489143259749 160 4993152
SGTC_1034 k072-0165 12.7 µM 1.16751722219978 0.101057669105197 no 376 0.12150077871256 167 5835461
SGTC_100 0086-0128 49.5915 µM 1.16511444423321 0.101528869904917 no 377 0.121986335416137 152 93297
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.1625865533739 0.102026331265353 no 378 0.122498644514698 149 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1881 5652484 16 µM 1.16095438086997 0.102348465875558 no 379 0.122830225946974 137 2255129
SGTC_3160 9100216 49.47 µM 1.16074381049185 0.102390079021555 no 380 0.122873049835545 144 17191039
SGTC_1417 3966-0327 90.4 µM 1.15979409308445 0.102577916090173 no 381 0.123066324814054 143 651118
SGTC_390 dec-rvkr-cmk 16.7 µM 1.15851636843425 0.102831022147517 no 382 0.123326687921473 137 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2479 5617353 43.85 µM 1.15377958802519 0.103773296064001 no 383 0.124295272349517 163 2731746
SGTC_2327 6189656 200 µM 1.15304084621273 0.103920814620344 no 384 0.124446809739872 141 5349088
SGTC_1648 st011736 69.8 µM 1.15152574113057 0.104223840015635 no 385 0.124758005815074 160 2855514
SGTC_2759 disulfiram 3.38 µM 1.15142165277677 0.104244681474748 no 386 0.124779405061845 166 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3344 9148862 3.898 µM 1.15137348475609 0.104254327109541 no 387 0.1247893086647 149 4905352
SGTC_1152 3909-8331 15.9 µM 1.1476323525706 0.105005465418223 no 388 0.125560184056975 131 16001939
SGTC_1751 st044839 27.194 µM 1.1462947089031 0.105274983763968 no 389 0.125836615738643 138 5291326
SGTC_2873 9040596 71.43 µM 1.14621089326881 0.105291888206245 no 390 0.125853950837497 170 6463863
SGTC_99 0109-0120 622.8 µM 1.14528999312617 0.105477750235787 no 391 0.126044524928178 145 759414
SGTC_1361 1608-0041 5.61 µM 1.14308961096904 0.105922806193927 no 392 0.126500693633844 150 X1361
SGTC_3166 9102297 49.47 µM 1.13850116675896 0.106855241136473 no 393 0.127455635977123 153 25237072
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.13554874953543 0.107458335731136 no 394 0.128072734200935 131 521171
SGTC_1946 st076057 65.1 µM 1.13286169633783 0.108009353051546 no 395 0.128636168772338 141 953009
SGTC_1353 1498-1206 8.11 µM 1.12879954161704 0.108846211754614 no 396 0.129491203038299 152 6756808
SGTC_1310 1188-0297 994 nM 1.12590472035492 0.109445422157349 no 397 0.130102925567274 149 1588352
SGTC_2045 5106652 78.05 µM 1.12562734437408 0.109502961438455 no 398 0.130161644417601 127 673349
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.12472612066178 0.109690062561486 no 399 0.130352554712256 168 7104
SGTC_1587 estradiol valerate 56.1 µM 1.12403864460164 0.109832942225116 no 400 0.130498316049554 171 13791 A steroid.
SGTC_2592 piperlongumine 83.33 µM 1.12293312373034 0.110062985090432 no 401 0.130732949167464 171 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2939 9044578 71.43 µM 1.1154589082704 0.111627332928521 no 402 0.132326908954302 151 2653634
SGTC_64 000l-0018 272.079 µM 1.11309471954251 0.112125451815311 no 403 0.132833875655605 191 6811119
SGTC_236 1509-0011 5.31 µM 1.10805581776612 0.113192412386354 no 404 0.133918855225093 200 3107280
SGTC_2955 9076254 12.21 µM 1.1064783778428 0.113527910901931 no 405 0.134259758841502 144 16459619
SGTC_1324 1418-0026 34.4 µM 1.10618336111543 0.113590735290404 no 406 0.134323581579953 143 1372513
SGTC_1519 esterone 74 µM 1.10563643799876 0.113707269198427 no 407 0.1344419558464 157 698 A steroid.
SGTC_1689 st020265 53.493 µM 1.10080052056737 0.114741376135192 no 408 0.1354917425779 156 5758320 YPR016C TIF6
SGTC_846 0335-0850 148 µM 1.0973180287981 0.115490200928241 no 409 0.136251196209862 157 6819598
SGTC_216 k038-0035 28.382 µM 1.09681049389695 0.115599623165384 no 410 0.136362120949659 184 4444231 YPR107C YTH1
SGTC_33 0986-0033 35.816 µM 1.09407818473777 0.116189962262263 no 411 0.136960344644259 132 2848082
SGTC_2170 morpholine 200 µM 1.09359423187913 0.116294747112442 no 412 0.137066490075421 147 121171 Reacts with secondary amines.
SGTC_403 arphamenine a 50 µM 1.09255156782718 0.116520731194838 no 413 0.137295368644916 174 5487158 An arginine aminopeptidase inhibitor.
SGTC_2693 st077581 40.7 µM 1.09239232997567 0.116555271356829 no 414 0.137330346424587 174 25238761
SGTC_992 3909-8734 162 µM 1.09169057970365 0.116707573988531 no 415 0.137484563594624 151 4288319
SGTC_2543 pimpinellin 60.67 µM 1.08991468872222 0.117093630310147 no 416 0.137875362780007 158 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2492 derrusnin 100 µM 1.08877758474043 0.117341297046565 no 417 0.138125989313414 181 1715307 Part of coumarin class of compounds.
SGTC_1321 1326-2144 215 µM 1.08588916232986 0.117972076824272 no 418 0.138764016153098 171 3513030
SGTC_615 k087-0205 167 µM 1.08469370057475 0.118233844870669 no 419 0.139028669416032 179 9642773
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.0832197221575 0.118557164220205 no 420 0.139355453884883 136 88881 An O-methylated flavonoid and antioxidant.
SGTC_278 4092-0821 23.9 µM 1.08184977207422 0.118858224556518 no 421 0.139659643220927 158 877900
SGTC_2847 9005661 71.43 µM 1.08087376525679 0.119073041009617 no 422 0.139876634986817 114 2991449
SGTC_2965 9082772 38.63 µM 1.08034277169501 0.119190026315543 no 423 0.139994784897808 113 16459634
SGTC_2642 cholecalciferol 100 µM 1.07991721917721 0.119283840031053 no 424 0.140089522352513 141 9821465 A vitamin D precursor, similar to steriods.
SGTC_232 clozapine 119 µM 1.07755751629885 0.119804985865485 no 425 0.140615634996346 160 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3153 9100258 49.47 µM 1.07494400952438 0.120384056228011 no 426 0.14119989836201 163 25236848
SGTC_3057 9095946 49.47 µM 1.07293807448313 0.12082984317964 no 427 0.141649450751371 182 24540043
SGTC_466 geldanamycin 89.2 µM 1.07205684517216 0.121026049145589 no 428 0.141847250262555 129 5288382 HSP90 inhibitor.
SGTC_685 1278-0033 54.9 µM 1.07120602998753 0.121215695977098 no 429 0.142038400448499 181 3590572
SGTC_2412 st077135 33.4 µM 1.06886522636645 0.121738539675522 no 430 0.142565201493908 171 13258915
SGTC_2544 sphondin 68.51 µM 1.06760644484164 0.122020356355614 no 431 0.14284903762378 177 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1773 st048542 73.5835 µM 1.06715641548529 0.12212122026193 no 432 0.142950605034819 202 3237138
SGTC_1420 4'-methoxyflavone 42 µM 1.0669364120714 0.122170550353247 no 433 0.143000275500592 163 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1985 st071382 65.5 µM 1.06298944386878 0.123057933879838 no 434 0.143893369246901 176 6123237
SGTC_1061 3448-9325 110 µM 1.06277663530125 0.123105906950837 no 435 0.143941628824461 185 723482
SGTC_2189 6047310 154.431 µM 1.06161711215242 0.123367526560843 no 436 0.144204771004782 153 711535
SGTC_127 0180-0333 59.125 µM 1.06054866406155 0.123608941791014 no 437 0.144447531542829 137 771601
SGTC_2545 solidagenone 89.61 µM 1.05638974136998 0.124551797314957 no 438 0.145395095445687 125 6708572 An anti ulcer agent
SGTC_397 arbidol 50 µM 1.05315727402064 0.125288083454307 no 439 0.1461344584048 161 131410 A RNA synthesis inhibitor.
SGTC_2160 5660466 132.927 µM 1.05088940982788 0.125806464320612 no 440 0.146654692408264 178 2859134
SGTC_3065 9113888 49.47 µM 1.04978274606156 0.126059964231759 no 441 0.146909004872769 157 16648368
SGTC_2283 7944793 200 µM 1.04760476828884 0.126559906186238 no 442 0.147410369826484 188 2970533
SGTC_3111 9122088 49.47 µM 1.04718788119532 0.126655757418442 no 443 0.147506466755866 147 16876704
SGTC_542 3381-0244 89.3 µM 1.04626255250031 0.126868690829758 no 444 0.147719914842841 184 1112843
SGTC_2694 st077685 81.9 µM 1.04519281260983 0.127115166076147 no 445 0.147966932317843 157 2838096
SGTC_1284 0929-0043 16 µM 1.04390723142956 0.127411813181114 no 446 0.148264156083326 178 1239883
SGTC_1040 k898-0338 155 µM 1.03638865188969 0.129156361648833 no 447 0.15001043120681 192 20969351
SGTC_3139 9095020 49.47 µM 1.03629238101481 0.129178806395764 no 448 0.150032879766713 141 25236292
SGTC_1698 5-fluorocytosine 1.055 µM 1.03563642755773 0.129331808419068 no 449 0.150185895413307 180 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2054 5233173 129 µM 1.03104558427954 0.130406144117971 no 450 0.151259721912875 115 6889
SGTC_1179 1021-1431 9.29 µM 1.02688710478529 0.131384613652393 no 451 0.15223681352876 203 2840958
SGTC_1941 st076221 61.8 µM 1.02402816386384 0.132060241513474 no 452 0.152910986244241 175 2828568
SGTC_1774 st048371 48.465 µM 1.01931898210687 0.133178336054544 no 453 0.154025777564541 216 4242727
SGTC_941 3237-0776 460 µM 1.0180101478972 0.133490244317127 no 454 0.15433656675097 171 760008
SGTC_2905 7799065 20.05 µM 1.01794193980261 0.133506512749556 no 455 0.154352774461713 175 1296806
SGTC_2065 5221596 34.26 µM 1.01637377733523 0.1338809140138 no 456 0.154725713968263 177 788581
SGTC_2886 9058944 51.95 µM 1.01479475962546 0.134258635473008 no 457 0.155101836133014 126 4949929
SGTC_2445 5742597 35.57 µM 1.0143390484245 0.134367783451963 no 458 0.155210498741124 198 1774255
SGTC_699 0375-0592 111 µM 1.01406823375943 0.134432675478186 no 459 0.155275097270683 141 762578
SGTC_2496 diffractaic acid 79.83 µM 1.01346916879081 0.134576298567935 no 460 0.155418057722516 181 94870 An apoptosis inducer which activates caspases.
SGTC_2828 7998861 71.43 µM 1.01263043865364 0.13477755718567 no 461 0.155618357578104 140 2988188
SGTC_2439 5492030 7.2 µM 1.01259681262984 0.134785630266918 no 462 0.155626391465938 182 5722370
SGTC_2398 5228213 48.84 µM 1.01155167695699 0.135036716389004 no 463 0.155876230367367 204 80771 YMR134W ERG29
SGTC_283 0987-0079 11.7 µM 1.00928631761963 0.135582052876753 no 464 0.156418670036037 171 411556
SGTC_2109 5483026 200 µM 1.00914293528842 0.13561661978643 no 465 0.156453044676374 230 759335
SGTC_2375 9072683 200 µM 1.00762115633903 0.135983865506128 no 466 0.156818184217216 195 16798029
SGTC_1690 st023502 41.2 µM 1.00721463248362 0.136082085645919 no 467 0.156915821427344 183 24207482
SGTC_2766 oltipraz 83.91 µM 1.00706830855443 0.136117450820544 no 468 0.156950974687124 195 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_535 2293-4129 48.2 µM 1.00661526923125 0.1362269862277 no 469 0.157059846939772 209 396118 YIL048W NEO1
SGTC_3086 9117350 49.47 µM 1.00315407109627 0.137065822005151 no 470 0.157893264643397 146 2679265
SGTC_763 3453-1109 128 µM 1.00292107330444 0.137122416497436 no 471 0.157949472034222 183 1560353
SGTC_926 2268-1401 59.4 µM 1.00080352139646 0.137637495592715 no 472 0.158460903390773 199 2931578
SGTC_1973 st070275 50.2 µM 1.00054679729143 0.137700031499614 no 473 0.158522981167768 154 17118334
SGTC_2369 9071472 200 µM 0.998595169907302 0.138176066053191 no 474 0.158995420457105 167 17296037
SGTC_2020 4017018 200 µM 0.997945720823207 0.138334726077115 no 475 0.159152839917714 175 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_683 panaxydol 45 µM 0.994760252833886 0.139114731927131 no 476 0.159926440981439 155 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_307 1501-1223 22.3 µM 0.994678759960499 0.139134725776159 no 477 0.159946263995557 165 2830329
SGTC_293 4049-0273 38.5 µM 0.993851663890103 0.139337760114776 no 478 0.160147544738837 183 1380311
SGTC_2108 5365811 200 µM 0.993718254149565 0.139370528213327 no 479 0.160180026617127 179 780283
SGTC_655 k060-0012 42 µM 0.993274370739231 0.139479592588318 no 480 0.160288131937857 198 5994525
SGTC_3103 9120822 49.47 µM 0.992607023552841 0.139643672351412 no 481 0.160450750326553 211 17141819
SGTC_2799 7812892 81.82 µM 0.991847766236333 0.139830509482008 no 482 0.160635896308443 219 20205235
SGTC_1841 st054148 70 µM 0.991244382264542 0.139979110608047 no 483 0.160783131819541 193 675442
SGTC_3349 9149703 23.001 µM 0.990937284301426 0.14005478374676 no 484 0.16085810254736 157 4910494
SGTC_1514 1189-1591 158 µM 0.990801520424001 0.140088246681793 no 485 0.160891253370991 205 767698 YMR146C TIF34
SGTC_2358 9037157 4 µM 0.990592284595368 0.140139829540766 no 486 0.160942353308431 202 2388925
SGTC_422 cantharidin 155 µM 0.987791914990112 0.140831446018321 no 487 0.161627283993836 194 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1650 st011916 45.8 µM 0.986759328005703 0.141087050813038 no 488 0.161880318902207 200 242528
SGTC_1140 3229-1848 2.98 µM 0.985860873685587 0.141309708441437 no 489 0.162100694537421 183 2849525
SGTC_2240 6690706 185.951 µM 0.985153755312875 0.141485116041417 no 490 0.162274276034724 165 805876
SGTC_1322 1348-1070 12 µM 0.983765875141656 0.141829822061783 no 491 0.162615320786579 194 6758089
SGTC_2167 5876490 200 µM 0.983107997640085 0.141993416775018 no 492 0.162777144266081 192 686534
SGTC_2717 st081029 62.2815 µM 0.981976778564888 0.142275016142168 no 493 0.163055644207922 187 5292846
SGTC_605 1315-0399 119 µM 0.981281621032467 0.142448252110298 no 494 0.163226941741737 198 24020461
SGTC_1012 4112-3522 18 µM 0.981273488438611 0.14245027962839 no 495 0.163228946429997 184 3112398
SGTC_1279 0874-0590 65.2 µM 0.980008666336288 0.142765847095608 no 496 0.163540920402731 178 3523074
SGTC_3019 9081971 49.47 µM 0.978591194870547 0.143120061064077 no 497 0.163891005826192 172 16451803
SGTC_2920 7982904 15.77 µM 0.978154466011127 0.143229315400064 no 498 0.163998966530544 191 6456808
SGTC_1497 4476-2978 41.3 µM 0.977028279881891 0.143511307772379 no 499 0.164277576017925 178 1528379
SGTC_1799 st045822 46.1415 µM 0.976888142044417 0.143546423912082 no 500 0.164312266462807 187 3674992
SGTC_2312 7706453 155.7 µM 0.974960731267044 0.144029988484181 no 501 0.164789869547821 185 976098
SGTC_1017 4239-0030 168 µM 0.974288084152918 0.144199005988656 no 502 0.164956759719661 178 1149593
SGTC_793 0488-0545 106 µM 0.972678179314481 0.144604073097366 no 503 0.165356636762492 203 292548
SGTC_1917 st066507 28.5 µM 0.970564774005019 0.145136988220925 no 504 0.165882527320106 203 3156428
SGTC_1158 4092-0494 91.8 µM 0.969966781785907 0.145288017208404 no 505 0.166031525094428 174 1148199
SGTC_2692 st077426 47.7 µM 0.969393324512401 0.145432948930578 no 506 0.166174490859389 194 25238571
SGTC_1459 k035-0031 35.7 µM 0.969270516369897 0.145463999269899 no 507 0.166205117878637 171 3877128 YMR208W ERG12
SGTC_987 1497-1013 404 µM 0.968950057344791 0.145545043895395 no 508 0.166285054054448 182 1676435
SGTC_2074 5212007 75.395 µM 0.965225579055233 0.146489197819941 no 509 0.16721591887613 188 758611
SGTC_1157 4092-0394 27.6 µM 0.959071401094142 0.148058270555509 no 510 0.168761388280106 173 3659885
SGTC_2180 6301957 200 µM 0.95706010619922 0.148573501244675 no 511 0.169268458998947 195 845462
SGTC_2927 9011802 47.9 µM 0.957051785556945 0.148575635219211 no 512 0.169270558758571 191 43912568
SGTC_458 nppb 133 µM 0.954269858929542 0.149290257953213 no 513 0.169973530457434 170 4549 A chloride channel blocker.
SGTC_711 k292-0785 179 µM 0.952626616851584 0.149713451233737 no 514 0.17038964315516 208 4146315
SGTC_2999 9069765 71.4286 µM 0.951984772718959 0.149878966068131 no 515 0.170552352245944 185 2097066
SGTC_2462 5162487 171.77 µM 0.951485173321452 0.150007884135886 no 516 0.170679070773544 193 2259986
SGTC_3108 9121785 49.47 µM 0.947553467945576 0.151025012681802 no 517 0.171678412193422 200 17140271
SGTC_1905 st060207 84.5 µM 0.94529121487093 0.151612330765161 no 518 0.172255111127172 202 1948547
SGTC_2713 st079149 53.4 µM 0.945113655102693 0.151658492370381 no 519 0.172300427342369 196 3103253
SGTC_2557 derrustone 83.84 µM 0.944285016756126 0.151874043492659 no 520 0.172512010235919 199 629853 An antioxidant.
SGTC_1220 1838-0075 193 µM 0.94398755735215 0.151951470307539 no 521 0.172588003336975 193 5529645
SGTC_2916 7875993 68.79 µM 0.943651934667703 0.152038862262403 no 522 0.172673771782906 213 1299250
SGTC_2663 amphotericin b 100 µM 0.941026890491435 0.152723542430746 no 523 0.17334553952193 210 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1876 myriocin 605 nM 0.940734373102525 0.15279996506541 no 524 0.173420499728893 216 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1142 3253-1408 9.78 µM 0.93610097534078 0.15401386144341 no 525 0.174610600459552 206 256655
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.934226233899067 0.154506830131209 no 526 0.175093603039845 201 16623 A steroid.
SGTC_3028 9087778 49.47 µM 0.932708608435528 0.154906657214745 no 527 0.175485219498318 198 17217395
SGTC_1113 artemisinin 1.17947 µM 0.931487266943615 0.155228922444164 no 528 0.175800784059726 230 2240 An anti-malaria and mitochondrial poison.
SGTC_2384 9036245 200 µM 0.930307422916416 0.155540658028649 no 529 0.176105967809671 173 6462766
SGTC_2842 9000675 19.48 µM 0.928176180372543 0.156104815950573 no 530 0.176658094052302 214 2989072
SGTC_2881 9058953 51.95 µM 0.927466339307168 0.156293015849422 no 531 0.176842230383221 188 17122249
SGTC_183 3914-0051 30.55 µM 0.920172183587335 0.158235568075731 no 532 0.178741393965081 190 1596232
SGTC_2749 bexarotene 57.39 µM 0.919593678380885 0.158390308644019 no 533 0.178892565730219 210 82146 An retinoic acid receptor inhibitor.
SGTC_505 gw-5074 63.9 µM 0.91938689813739 0.158445643011946 no 534 0.178946619910123 211 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2094 5332512 191.667 µM 0.919039337368163 0.158538678796696 no 535 0.179037498515881 210 755774
SGTC_1176 0848-0131 83.3 µM 0.919030698286668 0.158540991780117 no 536 0.179039757793339 211 6769040
SGTC_540 1187-0821 17.3 µM 0.916304474872287 0.159272002292964 no 537 0.179753610811281 217 847520
SGTC_3024 9090631 49.47 µM 0.915972688344645 0.159361118077799 no 538 0.179840609956086 187 25236383
SGTC_959 1222-0044 107 µM 0.915686486813976 0.159438016240596 no 539 0.179915677310161 198 6083612
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.915094205024677 0.159597230831067 no 540 0.180071088468416 199 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_277 nystatin 15.5 µM 0.914591155203806 0.159732540167929 no 541 0.180203151868778 206 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3260 9137109 49.47 µM 0.913872629463983 0.159925937919804 no 542 0.180391888586515 200 17478346
SGTC_835 0312-0010 67.2 µM 0.912022366060023 0.160424657839057 no 543 0.180878471913117 222 1626196
SGTC_2432 5630864 12.22 µM 0.910870172910373 0.160735732807073 no 544 0.18118189155322 210 5714970
SGTC_1494 4358-1428 177 µM 0.909390711445357 0.161135742546174 no 545 0.181571961535902 186 1564571
SGTC_2421 5690543 90.72 µM 0.908197977685111 0.161458700711783 no 546 0.181886816186302 218 3397993
SGTC_3087 9117406 49.47 µM 0.906431294671054 0.161937842970065 no 547 0.182353807465482 187 42546093
SGTC_41 0478-0632 82.643 µM 0.906417072661763 0.161941703877058 no 548 0.182357569838128 219 3750424
SGTC_3265 9137266 49.47 µM 0.905779536919672 0.162114839905049 no 549 0.182526277049655 161 17224265
SGTC_1940 st075990 51.1 µM 0.904593878941889 0.162437150302553 no 550 0.182840289652984 218 1084979
SGTC_2363 9053361 176 µM 0.904301154928801 0.162516788824893 no 551 0.182917867277439 217 6469797 YMR079W SEC14
SGTC_497 capsazepine 133 µM 0.902935727334923 0.162888602773921 no 552 0.183280003781257 204 2733484 A calcium channel blocker.
SGTC_1766 st045414 44.774 µM 0.902034399992784 0.163134342323705 no 553 0.183519297157997 212 253960
SGTC_788 1182-0090 188 µM 0.901283428654602 0.163339272441715 no 554 0.183718821161953 199 5715185
SGTC_1299 1079-1439 3.74 µM 0.900773024994423 0.163478650249069 no 555 0.183854506353596 207 323161
SGTC_1371 2421-0008 32.7 µM 0.899366099272317 0.163863244419891 no 556 0.184228845092628 223 2827552
SGTC_637 1181-0519 7.26 µM 0.898721489523998 0.164039649526876 no 557 0.184400513831612 221 6252091 YGR060W ERG25
SGTC_410 α-linolenic acid 100 µM 0.898543950487121 0.164088256821643 no 558 0.18444781247408 217 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_80 0159-0065 512.242 µM 0.89746393760034 0.164384148011069 no 559 0.184735704116539 194 1548079
SGTC_2593 nobiletin 86.24 µM 0.894386226132145 0.165229244882609 no 560 0.185557639746333 200 72344 An anti-infammatory.
SGTC_1758 st042942 75.2445 µM 0.893812818287268 0.1653870049115 no 561 0.185711024841485 220 669317
SGTC_1691 st019933 84.6 µM 0.893546484841449 0.165460313590207 no 562 0.185782295084112 237 6176082
SGTC_3315 9136395 68.55 µM 0.891661448345877 0.165979773479059 no 563 0.18628721153755 244 16876844
SGTC_985 1493-0307 8.71 µM 0.891111393727104 0.166131550557009 no 564 0.18643470652157 213 3278274
SGTC_2570 licareol 100 µM 0.886566892797562 0.167388947957414 no 565 0.18765606248861 204 443158
SGTC_1716 st033144 30.6155 µM 0.886274998523908 0.167469919924535 no 566 0.187734679026243 206 674617
SGTC_3155 9099265 49.47 µM 0.885755259641942 0.167614158834135 no 567 0.187874711814256 205 25236499
SGTC_2140 5586273 200 µM 0.878589556471933 0.169610950790438 no 568 0.189811930175197 196 854421
SGTC_1473 k844-0725 134 µM 0.878255992292923 0.169704271869638 no 569 0.189902406070783 231 54682906
SGTC_2318 6029776 164 µM 0.877319877375443 0.169966344119346 no 570 0.190156459316326 215 818325
SGTC_577 r071-0003 38.6 µM 0.875153408800931 0.170573857330072 no 571 0.190745220022604 241 4568517 YMR134W ERG29
SGTC_3237 9133362 49.47 µM 0.875040497825486 0.170605557484773 no 572 0.190775935411873 214 43845137
SGTC_981 1488-1094 54.9 µM 0.873786580087335 0.17095785280867 no 573 0.191117245035435 213 3449522
SGTC_1164 k060-0068 93.7 µM 0.873344347001891 0.171082211646674 no 574 0.191237707745022 227 5963676
SGTC_330 1488-0319 80.1 µM 0.872139834044124 0.171421221898038 no 575 0.191566048729069 227 6846614
SGTC_9 0092-0002 10.449 µM 0.86763178089515 0.172693821122341 no 576 0.192797971266643 228 759368
SGTC_507 nimesulide 162 µM 0.867526326175408 0.172723662335722 no 577 0.192826846851507 206 4495 A COX2 inhibitor.
SGTC_1889 st059080 5.18 µM 0.866749187333415 0.172943675767631 no 578 0.193039724278552 196 176925 Isolated from Daphnopsis sellowiana.
SGTC_1899 st063254 59.6 µM 0.866664325961947 0.172967711423789 no 579 0.19306297858101 205 3093813
SGTC_2493 resveratrol 26.09 µM 0.866137459332816 0.173116985778913 no 580 0.19320739250544 183 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2954 9074818 52.69 µM 0.865335357284515 0.173344398638241 no 581 0.19342737490426 221 16648742
SGTC_249 wiskostatin 11.211 µM 0.864249561236831 0.173652547572666 no 582 0.19372540579373 199 2775510 A n-wasp and actin depolymerizer.
SGTC_106 0092-0003 11.579 µM 0.864151375233823 0.173680429934548 no 583 0.193752369827939 204 1072148
SGTC_19 0279-0214 38.434 µM 0.863425615513294 0.173886615817843 no 584 0.193951750351082 229 3566274 YBR002C RER2
SGTC_1254 0550-0035 264 µM 0.863195141277299 0.173952125320869 no 585 0.194015092321124 215 15121435
SGTC_1327 1436-0082 2.18 µM 0.85919957507838 0.175090309923695 no 586 0.195115208890279 217 15992205
SGTC_2568 diosmetin 100 µM 0.858292117509638 0.175349466866942 no 587 0.195365590464806 241 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_477 mead ethanolamide 10 µM 0.857306237672937 0.175631295578381 no 588 0.195637831060759 172 16061185
SGTC_816 0325-0417 81.3 µM 0.854288191108288 0.176495832979243 no 589 0.196472664304937 221 68101
SGTC_3271 9137798 49.47 µM 0.85299692431568 0.176866544840679 no 590 0.196830504915387 192 6498326
SGTC_766 1391-0721 126 µM 0.852948734374746 0.176880389287498 no 591 0.196843867123707 240 1020919 YIL115C NUP159
SGTC_2583 asiatic acid 100 µM 0.852797055825306 0.176923969358318 no 592 0.19688592845635 248 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1980 st071811 45.7 µM 0.852299620873259 0.177066939291989 no 593 0.197023908205316 225 4974850
SGTC_3168 9103419 49.47 µM 0.851635555647155 0.177257914879626 no 594 0.197208199467509 221 16649256
SGTC_2175 5807670 165.306 µM 0.850913164627928 0.177465811783482 no 595 0.197408795683695 193 241186
SGTC_635 k038-0028 24.7 µM 0.850648674099697 0.177541967988051 no 596 0.197482271242685 223 4035102
SGTC_904 1141-0088 396 µM 0.85005249417198 0.177713704969314 no 597 0.197647950861835 212 1378119
SGTC_769 0302-0231 76 µM 0.850017334784091 0.177723836336403 no 598 0.197657724350212 244 571869 YER009W NTF2
SGTC_417 st075190 100 µM 0.8497618709814 0.177797460550256 no 599 0.197728746090021 235 222757
SGTC_270 tamoxifen 5.46 µM 0.846381255949819 0.178773559091126 no 600 0.19867004578889 240 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_213 1246-0773 967 nM 0.845787640324394 0.178945303655375 no 601 0.198835610815984 212 6251622
SGTC_2068 5226020 147 µM 0.844787116407953 0.179235009608806 no 602 0.199114854588541 235 1810509
SGTC_1367 1812-0510 76.9 µM 0.842637385800649 0.179858470360311 no 603 0.199715637732656 216 1142582 YDR527W RBA50
SGTC_1315 1237-0019 3.69 µM 0.842142854211489 0.180002085956413 no 604 0.199853998141186 209 825140
SGTC_259 usnic acid 108.925 µM 0.841991114484784 0.180046166717381 no 605 0.199896463548217 257 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2193 5925765 200 µM 0.84161322545302 0.180155973857347 no 606 0.20000224197618 208 877370
SGTC_3073 9114972 49.47 µM 0.841302984665412 0.180246155160648 no 607 0.200089109507045 203 41905075
SGTC_874 0599-0792 117 µM 0.841010936338093 0.180331074132622 no 608 0.200170903862969 219 765305
SGTC_1210 3013-0140 750 nM 0.839717250338179 0.180707541392484 no 609 0.200533469791202 215 905973
SGTC_3083 9117465 49.47 µM 0.839271318586567 0.180837423249913 no 610 0.200658537098973 232 16420915
SGTC_1525 8-methoxypsoralen 92.5 µM 0.838605077792069 0.181031581195033 no 611 0.200845480138617 234 4114 Related to psoralen; DNA damaging agent.
SGTC_1499 4480-0877 67.3 µM 0.83808276496125 0.18118388650967 no 612 0.200992110943957 215 2861909
SGTC_1302 1159-0335 255 µM 0.83556955644211 0.181917854477596 no 613 0.201698550671095 202 649284
SGTC_2192 5915882 198.485 µM 0.834364388408778 0.182270475502023 no 614 0.202037839181611 208 2876149
SGTC_405 ebelactone b 50 µM 0.833692016160219 0.182467390905825 no 615 0.202227279127947 208 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2291 7917025 104.35 µM 0.833627376597683 0.182486328676899 no 616 0.202245496831948 212 2964612
SGTC_271 rotenone 740 µM 0.833258206054014 0.182594509917244 no 617 0.20234956089882 215 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3251 9135047 49.47 µM 0.832323367290134 0.182868632883209 no 618 0.202613222186405 204 17682963
SGTC_181 1447-1644 8.07 µM 0.831002101920758 0.18325650559791 no 619 0.202986220971257 244 534600
SGTC_2711 st079103 59.1 µM 0.830685801679399 0.183349435244632 no 620 0.203075574659805 217 54693780
SGTC_207 4185-0010 4.486 µM 0.829714112431777 0.183635103233815 no 621 0.203350220254367 229 3761753
SGTC_866 0495-0101 262 µM 0.829682566701136 0.183644382043523 no 622 0.203359140291049 212 635694
SGTC_1825 st052143 62.6 µM 0.829642782982563 0.183656084378082 no 623 0.203370390077398 223 674173
SGTC_2541 muurolladie-3-one 83.07 µM 0.829601789225508 0.183668143130101 no 624 0.203381982419148 248 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_3242 9133940 49.47 µM 0.829401962066889 0.183726931489063 no 625 0.203438495807464 219 17248444
SGTC_3338 9144300 39.5675 µM 0.828367880956623 0.184031341322452 no 626 0.203731095325523 196 4901274
SGTC_429 1112-0049 25.5 µM 0.827904576179859 0.184167829457991 no 627 0.203862271565205 225 2836170
SGTC_2879 9041815 71.43 µM 0.827761594532873 0.184209964122502 no 628 0.203902764355352 188 4942971
SGTC_2998 9066762 71.4286 µM 0.824421584441961 0.185195924109537 no 629 0.204850027351113 208 4945196
SGTC_456 gingerol 170 µM 0.82411045536558 0.185287934963169 no 630 0.204938399962207 257 442793 A herb.
SGTC_2986 9022445 71.43 µM 0.823955515638038 0.185333766199084 no 631 0.204982417250505 234 6459286
SGTC_2977 9011197 71.43 µM 0.818801467469947 0.186862345041908 no 632 0.206449846780997 238 2704722
SGTC_1028 k015-0029 4.8 µM 0.816847934308717 0.187443753777972 no 633 0.207007667535945 236 4588309
SGTC_3007 9078383 71.4286 µM 0.816221505679416 0.187630427387894 no 634 0.207186729485883 225 6496995
SGTC_1449 4112-4002 201 µM 0.815682127052022 0.187791252383257 no 635 0.207340981939039 214 2059539
SGTC_2995 9067767 71.4286 µM 0.815244748516386 0.187921726790181 no 636 0.207466114065327 197 11673567
SGTC_2638 epoxomicin 18 µM 0.814741633328374 0.188071880303972 no 637 0.207610108357128 219 9915668 A protesome inhibitor.
SGTC_2144 5628481 200 µM 0.811109194057437 0.189158169166801 no 638 0.208651483210271 222 2818399
SGTC_857 0438-0306 1.35 µM 0.806509561349198 0.190539230347454 no 639 0.209974548602946 226 4686136
SGTC_1004 4084-0029 199 µM 0.804988892939048 0.190997176370399 no 640 0.210413044644785 228 716894 YLR208W SEC13
SGTC_706 4262-0057 46.9 µM 0.804237057928988 0.191223839042012 no 641 0.210630040301181 233 883298
SGTC_131 0141-0277 33.849 µM 0.802369758988716 0.191787503932576 no 642 0.211169550387902 241 1547771
SGTC_3049 9092223 49.47 µM 0.802252954486694 0.191822796442108 no 643 0.211203325065033 229 8623917
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.802155449206269 0.191852260731776 no 644 0.211231521687798 246 756377
SGTC_1036 k216-0215 33.5 µM 0.80203558513488 0.191888485230197 no 645 0.211266187058271 207 622330
SGTC_2709 st078560 56 µM 0.800753319695974 0.192276264626327 no 646 0.211637233997257 261 17250903
SGTC_334 1502-1024 68.5 µM 0.797742672419113 0.193188618773454 no 647 0.212509917567422 217 3296216
SGTC_2372 9071633 200 µM 0.797705360743842 0.193199942350109 no 648 0.212520746115108 223 21321366
SGTC_2201 6605497 169.863 µM 0.795716612892171 0.19380408592641 no 649 0.213098384307385 234 670741
SGTC_1609 st001574 46.4 µM 0.795341107358996 0.193918286442706 no 650 0.213207553792899 252 3960012
SGTC_2871 9038510 12.99 µM 0.795246239439858 0.193947144610341 no 651 0.213235139590277 258 4945164
SGTC_1792 st045773 43.6 µM 0.794307536389317 0.194232832655991 no 652 0.213508208858179 195 2919270
SGTC_964 1287-0107 19.4 µM 0.793722845991458 0.194410908761711 no 653 0.21367839858797 214 51516812 YPR165W RHO1
SGTC_1 0258-0098 57.368 µM 0.792895696613857 0.194662999026967 no 654 0.213919297395815 221 6790032 YDR047W HEM12
SGTC_1211 1056-0033 32.3 µM 0.790772258645015 0.195311069148014 no 655 0.21453845051669 237 6741922
SGTC_1872 amphotericin b 148 nM 0.78975000009315 0.195623527824538 no 656 0.214836892289871 233 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3283 9109332 35.8195 µM 0.789433718552016 0.195720262374745 no 657 0.214929277470497 210 17027281
SGTC_1219 1469-0211 33.1 µM 0.786831932853723 0.196517118582774 no 658 0.21569012880229 253 6822282
SGTC_2896 9052656 71.43 µM 0.78590645238442 0.196801041425896 no 659 0.215961147070387 252 6469436
SGTC_1246 0422-0085 105 µM 0.785565700994308 0.196905641124972 no 660 0.216060982589603 247 264295
SGTC_2623 humulene 100 µM 0.781097123107838 0.198280463236554 no 661 0.217372686919171 230 6187145 An anti-inflammatory.
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.779480255837068 0.198779339648885 no 662 0.217848431910088 236 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1688 st021091 57.6 µM 0.77892452010407 0.198950983762386 no 663 0.218012089464507 246 3656366
SGTC_599 1935-0052 86.5 µM 0.77821302330199 0.19917086645606 no 664 0.218221720228249 222 9557311
SGTC_2665 lovastatin 100 µM 0.777954145395853 0.199250907017271 no 665 0.21829802313083 252 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_327 1273-0057 3.96 µM 0.776710846360411 0.199635583380471 no 666 0.218664693099259 238 3108138
SGTC_475 α-linolenic acid 10 µM 0.776242004091439 0.199780758998067 no 667 0.218803054629254 237 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2351 9026858 72.31 µM 0.775755471248713 0.199931479574769 no 668 0.218946690130606 260 1409300
SGTC_3061 glucosamine 200 µM 0.774546967085262 0.200306151775962 no 669 0.219303702482918 226 91431 and experimental redox chemotherapeutic
SGTC_553 k007-0256 45.7 µM 0.774437845343266 0.20034000351167 no 670 0.219335955331935 234 6287000
SGTC_2769 toremifene 3.73 µM 0.773870231850182 0.20051614394202 no 671 0.219503767438608 247 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2611 pyromycin 23.93 µM 0.773739878120032 0.200556608120307 no 672 0.219542316281791 237 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_7 0192-1582 4.227 µM 0.773063636529301 0.200766604547522 no 673 0.219742360156285 274 252616
SGTC_2823 7987624 58.44 µM 0.772640092947705 0.200898196681409 no 674 0.219867704898427 266 2239440
SGTC_1991 st073000 8.92 µM 0.772453460417102 0.200956198572792 no 675 0.219922950504641 251 4301969 YIL048W NEO1
SGTC_2948 9070189 9.45 µM 0.771234412124098 0.201335302993066 no 676 0.22028400021706 225 6473636 YDL196W YDL196W
SGTC_2041 5107442 45.335 µM 0.769777957826795 0.201788798486371 no 677 0.220715808516217 255 793005
SGTC_1501 4491-0275 38.4 µM 0.768751020249811 0.202108922941502 no 678 0.221020565275533 251 5104718
SGTC_480 am 92016 50 µM 0.768485610709704 0.202191707727807 no 679 0.221099368071303 286 2129 K+ channel blocker.
SGTC_3250 9135583 49.47 µM 0.76690889782356 0.202683923663026 no 680 0.221567841504613 233 7699353
SGTC_2141 5621638 7.665 µM 0.766368394604686 0.202852821845251 no 681 0.221728566475239 247 2856238
SGTC_2488 5268135 45.7 µM 0.765636988186642 0.203081507888014 no 682 0.221946164769627 254 1270356 YLR208W SEC13
SGTC_134 0269-0018 6.916 µM 0.765548633424791 0.203109143849567 no 683 0.221972459153766 248 4378915
SGTC_2264 7948757 110.76 µM 0.765481068686676 0.203130278537868 no 684 0.221992567625279 247 2971411
SGTC_1579 chlormadinone acetate 49.4 µM 0.764261876253585 0.203511875389089 no 685 0.222355599716111 244 45114258 A steroidal progestin.
SGTC_158 k038-0087 26.446 µM 0.76424749956441 0.203516377719686 no 686 0.222359882601507 236 X158
SGTC_1754 st042065 16.137 µM 0.760155252420495 0.204800355780995 no 687 0.223580894510712 245 1126236 YIL048W NEO1
SGTC_2218 6965428 192.983 µM 0.75966853929096 0.204953386162752 no 688 0.223726369374035 240 675684
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.757559404764335 0.205617316908319 no 689 0.224357395189822 249 115019
SGTC_1815 st051655 58.2 µM 0.756737239823991 0.205876470209149 no 690 0.224603649724811 255 5984156
SGTC_2918 7977171 22.06 µM 0.753824169724406 0.206796252720272 no 691 0.225477404417673 255 2236483
SGTC_1138 3761-0006 1.03 µM 0.753745799502858 0.206821031152986 no 692 0.225500937556559 244 12061087
SGTC_1990 st072050 59.8 µM 0.753623290464373 0.206859768543746 no 693 0.225537727556984 257 17233948
SGTC_47 0149-0135 24.25 µM 0.752310771707566 0.207275056733813 no 694 0.225932095778813 247 5239155
SGTC_2158 5657123 3.6195 µM 0.752309885558514 0.20727533728271 no 695 0.225932362168764 266 2858827
SGTC_1574 spiramycin 23.7 µM 0.751343900794753 0.207581295154117 no 696 0.226222857548844 268 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1469 k284-2957 126 µM 0.751164452907087 0.207638161344174 no 697 0.226276845175993 235 23884841
SGTC_1396 3511-0007 98.6 µM 0.750643542180304 0.207803287630372 no 698 0.226433604511191 250 X1396
SGTC_2680 butyl paraben 22.24 µM 0.7493617089043 0.20820995294103 no 699 0.226819611720705 288 7184 An antifungal and steroid mimetic.
SGTC_265 mycophenolic acid 32.932 µM 0.74918163655802 0.208267119007154 no 700 0.226873867859327 252 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1359 1582-0056 520 nM 0.747163502295705 0.20890843245573 no 701 0.227482436084461 259 3661189
SGTC_859 0439-0102 54.6 µM 0.74531369928927 0.209497274954607 no 702 0.228041050694748 267 610143
SGTC_2098 5376439 882.5 nM 0.745099597654516 0.209565492306028 no 703 0.22810575616996 240 2844116
SGTC_1924 st058459 75.1 µM 0.744974444466209 0.209605374833954 no 704 0.228143584559946 255 688683
SGTC_603 3794-0023 45.9 µM 0.743728782681678 0.210002572758838 no 705 0.228520286399175 270 3802260
SGTC_2743 auranofin 4.32 µM 0.739877939191437 0.211233265550039 no 706 0.229687030778489 217 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1343 1487-0095 224 µM 0.739142295555074 0.211468850050532 no 707 0.229910298068022 281 4560101 YGL055W OLE1
SGTC_702 1488-0190 94 µM 0.735939669991437 0.212496258874943 no 708 0.230883706891811 233 949357
SGTC_2666 tannic acid 100 µM 0.735702554463242 0.212572441781564 no 709 0.230955867376617 275 16134267 A thiamine antagonist.
SGTC_2093 5331342 194.4 µM 0.735555270083515 0.212619770847025 no 710 0.231000696221535 251 33839
SGTC_607 4491-0986 66.8 µM 0.733623893647035 0.21324097780784 no 711 0.231588997194413 230 698981 YDR232W HEM1
SGTC_638 3970-0837 4.09 µM 0.73338407809866 0.213318185760908 no 712 0.231662103710084 253 4118451 YLR208W SEC13
SGTC_1479 0549-0158 134 µM 0.732880774543324 0.213480275936068 no 713 0.231815574976873 243 5440202
SGTC_3246 9135460 32.98 µM 0.731560167835757 0.213905921759735 no 714 0.232218533872508 267 41446951
SGTC_2789 5281112 71.43 µM 0.727462385181638 0.215229822632657 no 715 0.233471374906517 250 765948
SGTC_2797 7859098 81.82 µM 0.727371569052043 0.215259217033618 no 716 0.233499183098304 258 972681
SGTC_1633 st005664 67.9 µM 0.727364701169008 0.215261440051859 no 717 0.233501286140955 258 2063822
SGTC_1010 4112-3296 15.2 µM 0.727076091101264 0.21535487032051 no 718 0.233589672110666 247 704384
SGTC_169 k015-0017 16.025 µM 0.726879921979412 0.215418388581197 no 719 0.23364975890618 306 1840002
SGTC_2902 5787006 60.46 µM 0.72538774616626 0.215901900844591 no 720 0.234107094225205 260 591003
SGTC_1052 3253-3998 198 µM 0.725008252801073 0.216024968952862 no 721 0.234223483746542 246 5450317
SGTC_312 4092-0653 6.84 µM 0.722283834512774 0.216909678679489 no 722 0.235059994799229 263 1148278
SGTC_244 nsc-207895 1.295 µM 0.721684578149898 0.217104557893509 no 723 0.235244212894091 222 42640
SGTC_1407 3909-7909 12.3 µM 0.721665677045925 0.217110706210716 no 724 0.235250024600928 247 4411780
SGTC_1784 st039334 36.3 µM 0.721191342545335 0.217265034843445 no 725 0.235395898812414 291 3496984
SGTC_3132 9126706 49.47 µM 0.720256965992328 0.217569227205107 no 726 0.235683397793074 271 850858
SGTC_1661 st013063 9.66 µM 0.719836214514161 0.217706285807832 no 727 0.2358129223204 280 721395
SGTC_1808 st050063 61.5 µM 0.718541893786464 0.218128219301523 no 728 0.236211613163493 269 4011993
SGTC_2357 9067248 200 µM 0.718185160401043 0.218244593031529 no 729 0.236321563312137 277 9150235
SGTC_1877 wortmannin 25 µM 0.717868578728251 0.218347898405614 no 730 0.236419161744384 262 312145 A covalent inhibitor of PI 3-kinase.
SGTC_963 1269-2853 151 µM 0.716763960511193 0.218708572523621 no 731 0.236759876344184 247 3668223
SGTC_220 paclitaxel 373.376 µM 0.714718386758893 0.219377387130949 no 732 0.2373915369669 252 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1971 st069429 63.5 µM 0.71400520615201 0.219610842513179 no 733 0.237611980100082 265 1246522 YGL099W LSG1
SGTC_2536 dehydroabietamide 32.04 µM 0.712925628972707 0.219964506919839 no 734 0.237945889512118 261 3983547
SGTC_770 0389-1121 67.2 µM 0.712919576302118 0.219966490667067 no 735 0.237947762306697 259 6753108
SGTC_1657 st012939 43.4 µM 0.712359481807401 0.22015010461961 no 736 0.238121099609119 260 24207257
SGTC_2641 levomentholum 100 µM 0.710563521234743 0.220739461017776 no 737 0.23867737749387 266 16666
SGTC_66 0109-0187 42.4 µM 0.710117878519956 0.220885841438474 no 738 0.238815520172036 228 759417
SGTC_1044 1222-0021 1.78 µM 0.709737567506005 0.221010806270199 no 739 0.238933445564068 266 4306703
SGTC_2614 arthonioic acid 13.39 µM 0.708410460696532 0.221447191654296 no 740 0.239345199106383 264 6710684
SGTC_3034 9090421 49.47 µM 0.707498547270412 0.221747336565697 no 741 0.239628357579821 252 17173761
SGTC_631 k072-0230 41.5 µM 0.70731754985436 0.221806937234309 no 742 0.239684580873412 264 5773147
SGTC_2279 7948423 32.93 µM 0.705925762271859 0.222265544796765 no 743 0.240117152781682 237 1247112
SGTC_23 0213-0011 39.996 µM 0.705796031175632 0.222308320004275 no 744 0.240157495280772 277 627608
SGTC_446 go6976 132 µM 0.705375024192179 0.222447167651467 no 745 0.240288441332036 274 3501 A protein kinase C inhibitor.
SGTC_1948 st076329 66.6 µM 0.704777994120292 0.222644152295647 no 746 0.240474202629257 264 24208413
SGTC_1403 3909-7815 62.9 µM 0.704267605764752 0.222812629102424 no 747 0.240633068011476 268 6615483
SGTC_2377 9073351 62.6 µM 0.704101485456236 0.222867480304232 no 748 0.240684787558986 274 7337946 YHR072W ERG7
SGTC_773 4358-1457 44.6 µM 0.703381572456646 0.223105276996575 no 749 0.240908993667684 284 1186886
SGTC_2387 9077560 195.08 µM 0.699966660912981 0.224235233013827 no 750 0.241974062605602 249 5303272
SGTC_5 0352-0601 109.883 µM 0.698895922813347 0.22459019629584 no 751 0.242308537853249 257 762456
SGTC_352 k048-0007 5.11 µM 0.696946755656346 0.22523718758262 no 752 0.242918057845269 290 6811911
SGTC_3011 9081274 71.4286 µM 0.696626400198833 0.22534362478324 no 753 0.243018314844452 277 6625322
SGTC_1594 piperine 70.1 µM 0.696525197329299 0.225377255071114 no 754 0.243049991489384 259 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2512 diallyl trisulfide 49.23 µM 0.695608469576397 0.225682018331819 no 755 0.243337030309898 299 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1406 3909-7906 11.9 µM 0.694923286803877 0.225909957369095 no 756 0.243551689103259 269 X1406
SGTC_3180 9109287 49.47 µM 0.694659927814075 0.225997603350109 no 757 0.243634223229415 262 18891271
SGTC_2052 5265182 7.135 µM 0.688253212756003 0.228135673877567 no 758 0.245646669733379 258 1239884
SGTC_1830 st055982 50.3 µM 0.687886255493713 0.228258479511646 no 759 0.245762206276904 299 455313 An antimicrobial agent.
SGTC_1660 st012960 28.1 µM 0.6869444799785 0.228573823379186 no 760 0.246058857893742 277 24207266
SGTC_2102 5377816 72.7585 µM 0.685316265951483 0.229119590921806 no 761 0.246572184841963 268 1379702
SGTC_2399 5884133 200 µM 0.684620435012147 0.229353052006808 no 762 0.246791734263685 271 722445
SGTC_2532 xanthone 78.9 µM 0.684280583705155 0.229467125360937 no 763 0.246899002588497 251 7020 An insecticide.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.684008787393194 0.229558378480517 no 764 0.246984808458788 271 94937 An inhibitor of serotonin biosynthesis.
SGTC_1426 4048-4480 71.7 µM 0.683668835154075 0.22967254294081 no 765 0.247092153554569 260 14224343
SGTC_1303 1160-0052 261 µM 0.682312101626439 0.230128484551475 no 766 0.247520811258601 269 3562476
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.681863794576037 0.230279253105272 no 767 0.247662540410587 261 279621
SGTC_2025 5147754 141 µM 0.681057190174152 0.230550658425126 no 768 0.247917651881557 261 315777 YLR208W SEC13
SGTC_1404 3909-7820 48.3 µM 0.681008448572681 0.230567064668684 no 769 0.247933072284844 270 23741373
SGTC_918 glabranin 770.725 nM 0.679561185997069 0.231054505112044 no 770 0.248391176579525 262 124049 Also referred to as licorice root.
SGTC_1408 3909-7976 48.8 µM 0.679318177100046 0.231136407271376 no 771 0.248468140779702 281 24152374
SGTC_1969 st069479 40.1 µM 0.677737719037508 0.231669469840082 no 772 0.248969003133032 283 3895485
SGTC_2602 kawain 100 µM 0.677728926066106 0.231672437480166 no 773 0.248971791212334 272 5369129
SGTC_3201 9113999 49.47 µM 0.676373508724586 0.23213014595537 no 774 0.249401766156178 276 16649224
SGTC_1812 st052057 4.327 µM 0.676208672260464 0.232185843595497 no 775 0.249454083634173 271 3645418
SGTC_916 4466-0038 42 nM 0.675607571125333 0.23238901647727 no 776 0.249644916646113 285 5722064 YGL116W CDC20
SGTC_2741 miltefosine 3.04 µM 0.674798143026408 0.232662760285873 no 777 0.249902010176569 257 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_98 0074-0023 107.663 µM 0.67418528573571 0.232870144180066 no 778 0.250096761606279 277 3563821
SGTC_1373 2887-0003 58.5 µM 0.674169732739109 0.232875408471948 no 779 0.250101705024983 287 776948
SGTC_1786 berberine 21.6 µM 0.672698957133482 0.233373527056149 no 780 0.250569415598791 287 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1681 tripelennamine 100 µM 0.672653018705421 0.233389094882088 no 781 0.25058403160076 255 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_692 k241-0027 77.8 µM 0.672590367827315 0.233410327228691 no 782 0.25060396564813 272 3600480
SGTC_3226 9131256 49.47 µM 0.67135517431491 0.233829152359935 no 783 0.250997146880403 251 17178073
SGTC_2205 7238770 200 µM 0.670178791096759 0.234228423203053 no 784 0.251371911146171 276 279867
SGTC_616 4092-0450 108 µM 0.66962099331839 0.23441787462314 no 785 0.251549713936963 305 787165
SGTC_1381 2324-0066 62.1 µM 0.669361976584055 0.234505876342392 no 786 0.251632300311685 284 10885928
SGTC_2511 berberine 10.47 µM 0.667054416867476 0.235290682877726 no 787 0.25236868753005 291 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_432 NS 1619 61.3 µM 0.666927865048624 0.235333765352835 no 788 0.252409105510025 276 4552 A K+/calcium channel activator.
SGTC_2564 betulinic acid 100 µM 0.666090014384655 0.235619107586964 no 789 0.252676783371071 296 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3230 9131665 49.47 µM 0.665661920933781 0.235764974673611 no 790 0.252813609033069 279 15943720
SGTC_2617 dihydrotanshinone i 20.83 µM 0.6645818564535 0.236133213311674 no 791 0.253158988562809 275 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1334 1486-0610 236 µM 0.6635833222164 0.23647393658451 no 792 0.253478517244917 262 3742339
SGTC_2145 5634607 200 µM 0.663553458055327 0.236484131101517 no 793 0.253488076971224 289 308662
SGTC_1072 oxiconazole 14.9 nM 0.663048890190907 0.236656408418404 no 794 0.253649621299903 261 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3297 9117502 71.43 µM 0.662853201301626 0.236723242103224 no 795 0.253712288332905 263 7453720
SGTC_3075 9116269 49.47 µM 0.66094935798769 0.237374003778657 no 796 0.254322395514217 290 17015205 YNL244C SUI1
SGTC_2997 9067075 71.4286 µM 0.660934163910216 0.237379201285992 no 797 0.254327267712233 287 27209819
SGTC_990 3985-0011 41.3 µM 0.660842681774016 0.237410496317967 no 798 0.254356603800316 276 5399565 YGL099W LSG1
SGTC_1504 k297-0033 30 µM 0.660740234999025 0.237445544920708 no 799 0.254389458085589 243 4388117
SGTC_1793 st048256 72.231 µM 0.660452799559585 0.23754389612752 no 800 0.254481649394445 284 672022
SGTC_1846 st056244 14.8 µM 0.659251745924162 0.237955100033857 no 801 0.254867061591011 292 5393182
SGTC_366 0181-0206 4.31 µM 0.658438447770149 0.238233769812146 no 802 0.255128218339453 291 274874
SGTC_1635 st007035 42.4 µM 0.657085249932224 0.238697827625538 no 803 0.255563051290939 272 3716403
SGTC_159 3970-0959 50 µM 0.653869632563887 0.239802554233961 no 804 0.256597900008891 282 6615653
SGTC_1119 parthenolide 318.541 nM 0.653652500283531 0.239877250516359 no 805 0.25666785600759 307 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_157 1348-1695 65.819 µM 0.653370488546988 0.239974285104801 no 806 0.256758729788183 274 5380510
SGTC_34 0469-0683 81.75 µM 0.65273916950815 0.240191586909694 no 807 0.256962222969133 270 3690923
SGTC_727 3032-0951 202 µM 0.652470887014049 0.240283962964675 no 808 0.257048723911772 286 3652836
SGTC_200 k038-0079 37.545 µM 0.65108380601933 0.240761876623519 no 809 0.257496194754732 304 3436683
SGTC_3064 1327-0027 10 µM 0.650315800121352 0.241026712556186 no 810 0.257744126564698 271 16000455 YPR107C YTH1
SGTC_1920 st075728 45.7 µM 0.649778569698012 0.241212062965047 no 811 0.257917631819291 281 3400306
SGTC_2968 9090663 33.37 µM 0.648856776875967 0.241530272053773 no 812 0.258215477415667 305 25236811
SGTC_3127 9126946 49.47 µM 0.648416417439786 0.241682367523091 no 813 0.258357827305296 274 27243249
SGTC_1958 st076513 41.9 µM 0.647654429643358 0.241945672782042 no 814 0.258604242288446 290 732122 YGL099W LSG1
SGTC_847 0342-0274 5.54 µM 0.647199568784709 0.242102924314648 no 815 0.258751395186516 299 18097
SGTC_538 2922-0838 53.3 µM 0.646858613005265 0.242220833654739 no 816 0.258861726847745 279 777039
SGTC_2589 lobaric acid 100 µM 0.645837667603556 0.242574083103275 no 817 0.259192245410602 291 73157 A novel microtubule depolymerizer.
SGTC_1444 4112-3581 28 µM 0.644929317907523 0.24288860855876 no 818 0.25948649576561 289 2877249
SGTC_833 3852-0053 558 µM 0.644912026673816 0.242894597966329 no 819 0.259492098752232 301 3123681
SGTC_2517 totarol 10 µM 0.644801660563003 0.2429328289096 no 820 0.259527862845601 267 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2426 5582046 32.21 µM 0.644550662855782 0.243019786913451 no 821 0.259609208026519 284 2251934
SGTC_1705 st027868 56.3335 µM 0.64437812520172 0.243079572242292 no 822 0.259665132930226 292 292948
SGTC_2107 5363541 170.161 µM 0.643848904548897 0.243262999967288 no 823 0.259836708842857 274 244052
SGTC_1984 st072354 53.1 µM 0.643101649583934 0.243522125673184 no 824 0.260079072104668 287 5762938
SGTC_1255 0566-0045 221 µM 0.64309909646389 0.24352301127447 no 825 0.260079900378536 285 2788469
SGTC_378 3970-0959 8.33 µM 0.642688311920601 0.243665522849572 no 826 0.260213183307833 302 6615653
SGTC_2361 9034121 116 µM 0.640832684899575 0.24430984769706 no 827 0.260815697396279 315 6496917
SGTC_389 tpck 16.7 µM 0.636722916923121 0.245740135659497 no 828 0.262152671707549 281 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3329 9141233 27.5565 µM 0.635706718134172 0.246094486761891 no 829 0.262483798400922 298 4909101 YNL103W MET4
SGTC_386 1509-0011 3.07 µM 0.634956114639824 0.246356399992444 no 830 0.262728518716788 285 3107280
SGTC_1394 3474-0001 65.7 µM 0.634355453047416 0.246566100538756 no 831 0.262924437299301 280 5017666 YIL048W NEO1
SGTC_1895 st058434 18.3 µM 0.634159142918531 0.246634656263706 no 832 0.262988484223465 321 5393175
SGTC_3339 9145883 14.936 µM 0.633947571164423 0.246708553105881 no 833 0.263057519238473 282 2030670
SGTC_2684 capsaicin 100 µM 0.632565505558105 0.247191566389061 no 834 0.263508709435114 305 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2910 7948405 25.97 µM 0.632171155531399 0.24732947908011 no 835 0.263637521633575 281 2971328
SGTC_193 1273-0060 1.558 µM 0.630831074851426 0.247798441349597 no 836 0.264075491317253 300 2847393 YHR072W ERG7
SGTC_2003 4023581 200 µM 0.629589289650081 0.24823342845142 no 837 0.264481666395117 302 16641307
SGTC_1855 st056195 39.6 µM 0.629344818714452 0.248319112546749 no 838 0.264561667745019 283 4028379
SGTC_1882 5615643 20 µM 0.62829115035261 0.248688590872453 no 839 0.264906613937958 283 2253075
SGTC_1161 k007-0610 110 µM 0.627858563717714 0.248840366014728 no 840 0.265048298765614 299 5843850
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.626228022102653 0.249412892475686 no 841 0.265582694837546 303 165506
SGTC_1556 plumbagin 1.48 µM 0.626074530706949 0.249466823412811 no 842 0.265633028458736 293 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2707 st078556 66.6 µM 0.625745943327464 0.249582297133819 no 843 0.265740796639916 287 17250899
SGTC_531 3788-1495 174 µM 0.625618351146481 0.249627143830301 no 844 0.265782649556387 297 2896655
SGTC_2015 5119600 184 µM 0.625531676151678 0.249657611204186 no 845 0.26581108268169 307 2828786
SGTC_2888 9058547 12.99 µM 0.625356636887422 0.249719145775056 no 846 0.265868507787175 280 16476514
SGTC_2772 vinpocetine 57.06 µM 0.625338091315138 0.249725665891727 no 847 0.265874592398642 327 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1097 itavastatin 7.23 µM 0.625276363525245 0.249747368347855 no 848 0.265894845159751 295 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_908 3448-7491 47.7 µM 0.623531505140098 0.250361245348805 no 849 0.266467652785973 255 1203031
SGTC_2474 5321570 43.32 µM 0.623073608086899 0.250522475326276 no 850 0.26661807600886 303 2841384
SGTC_1879 gemcitabine 100 µM 0.622435905962366 0.250747108036084 no 851 0.266827638293717 322 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3216 9129716 49.47 µM 0.622432380132676 0.250748350317815 no 852 0.266828797186575 271 8056934
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.622251318691991 0.250812149419117 no 853 0.266888313068626 297 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1144 3486-0183 12.5 µM 0.621734820251077 0.250994190857015 no 854 0.267058125764514 328 6744069
SGTC_1682 st012968 530 nM 0.621594876511547 0.251043526486771 no 855 0.267104145408835 285 24207270
SGTC_338 4055-0136 114 µM 0.618599005607663 0.252100917333227 no 856 0.268090278555515 290 2900563
SGTC_1087 pterostilbene 9.05 µM 0.61709881651103 0.25263128962674 no 857 0.268584774630622 309 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.616288836172642 0.252917891749134 no 858 0.268851952813095 284 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2861 9024595 19.48 µM 0.616133370700738 0.252972920966159 no 859 0.268903249546073 276 16482810
SGTC_2754 granisetron 64.02 µM 0.615224239183569 0.253294847117309 no 860 0.269203321117327 317 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2720 fluspirilene 36.88 µM 0.614013963819516 0.253723743174489 no 861 0.269603049908528 298 3396 An atypical antipsychotic.
SGTC_2331 7980721 200 µM 0.612958525023427 0.254098079470494 no 862 0.269951881978559 295 2981221
SGTC_694 1315-0438 43.2 µM 0.61278481825317 0.254159716430448 no 863 0.270009315278433 295 6793154
SGTC_813 k007-0158 173 µM 0.611932549583633 0.254462243378752 no 864 0.270291192526589 303 6523916
SGTC_2928 9011484 9.79 µM 0.611570647799575 0.254590763490763 no 865 0.270410931519447 296 2994751
SGTC_224 benfluorex 43.875 µM 0.607533097053115 0.256026898239263 no 866 0.271748592503684 316 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1967 st070177 51.4 µM 0.606818728193167 0.256281434634337 no 867 0.271985608965639 318 5729214
SGTC_315 k915-0449 187 µM 0.605225418860575 0.256849620698037 no 868 0.272514614289883 303 20970215 YNL149C PGA2
SGTC_3343 9148379 18.9835 µM 0.605060709372999 0.256908394703104 no 869 0.272569329713812 289 1955036
SGTC_588 3970-1144 52.9 µM 0.604933906108016 0.2569536472325 no 870 0.272611456651491 286 1888707
SGTC_1306 1185-0270 9.02 µM 0.604332429720748 0.257168353763581 no 871 0.272811324841953 303 1548076
SGTC_1737 st035557 69.7 µM 0.603967355091054 0.257298718417102 no 872 0.272932673116666 306 5716916
SGTC_856 0433-0016 11.3 µM 0.603170109092986 0.25758352668631 no 873 0.273197765167945 292 3911780
SGTC_2605 digitonin 300 nM 0.601765378048529 0.258085751085592 no 874 0.27366516210055 305 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1937 st074714 47.2 µM 0.601385379294498 0.258221696789929 no 875 0.273791667244211 293 17250970
SGTC_2689 tacrolimus 100 µM 0.600366597707341 0.258586352064518 no 876 0.274130971811379 290 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_459 nigericin 15.3 µM 0.600111566454559 0.25867767780974 no 877 0.274215942306908 323 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1853 st056710 91.2 µM 0.599980588991375 0.258724586842016 no 878 0.274259586013381 315 269167
SGTC_762 1165-0429 115 µM 0.599564013917924 0.258873810734042 no 879 0.274398418038379 302 5967793
SGTC_1811 st050069 61.5 µM 0.598098757773212 0.259399042608644 no 880 0.274887019545826 305 3877702
SGTC_3144 9087057 49.47 µM 0.597007021233427 0.259790741210453 no 881 0.27525134645629 324 17249618
SGTC_744 1594-0068 283 µM 0.596412283623726 0.260004252438487 no 882 0.275449918220798 314 668392
SGTC_2681 menadione 3.18 µM 0.595483342145788 0.260337924051543 no 883 0.275760215340129 316 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2752 diclazuril 33.15 µM 0.595448637468368 0.260350394089414 no 884 0.275771811176128 304 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_453 enantio-paf c16 10 µM 0.594631955110755 0.260643932086584 no 885 0.276044757510872 334 13871343 A lipid and platelet activating factor
SGTC_1976 st070609 63.5 µM 0.594513574118396 0.26068649558748 no 886 0.276084333050935 299 682556
SGTC_2097 5376186 200 µM 0.593688671151095 0.260983186044205 no 887 0.276360180816779 307 742755
SGTC_565 1418-0001 44.5 µM 0.592663389057149 0.261352188143958 no 888 0.276703223748389 312 2862145
SGTC_1712 st032288 53.4 µM 0.591919870749294 0.261619950144883 no 889 0.27695212348568 302 2883011
SGTC_1740 st038286 13.222 µM 0.589816471870238 0.262378205469912 no 890 0.277656849135612 287 716786
SGTC_2275 7947463 200 µM 0.58926705937814 0.26257644866107 no 891 0.277841069232776 308 1225414
SGTC_384 k007-0144 5.16 µM 0.587870036553597 0.263080878104142 no 892 0.278309764891823 314 6824886
SGTC_2206 7254556 146.969 µM 0.587742655144588 0.263126896916595 no 893 0.278352520019018 296 4398905
SGTC_899 1083-0020 478 µM 0.587741716441176 0.263127236055259 no 894 0.278352835103438 321 767123
SGTC_2336 9001819 198.65 µM 0.587227937397197 0.263312889787745 no 895 0.278525315837936 319 2989602
SGTC_1718 roemerine 11.9335 µM 0.586864175259769 0.263444375440235 no 896 0.278647465876387 286 235224 An aporphine alkaloid with mutagenic activity.
SGTC_86 0417-1630 471.922 µM 0.586596956125156 0.263540985957298 no 897 0.278737213732266 297 3634867
SGTC_1134 3477-0009 42.5 µM 0.585451849639897 0.263955192877454 no 898 0.279121966914049 332 3973534
SGTC_1489 4065-0444 182 µM 0.583976245344091 0.264489436020644 no 899 0.279618147043675 308 2877968
SGTC_96 0929-0093 37.281 µM 0.58381349704029 0.264548392783799 no 900 0.279672898267132 307 6991579
SGTC_467 ro 31-8220 72.8 µM 0.583583246041852 0.264631814311562 no 901 0.279750367400842 324 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_569 4130-2812 160 µM 0.583539876023659 0.264647529066244 no 902 0.279764960631919 327 743552
SGTC_2691 st077356 60.2 µM 0.582730247958518 0.264940977972015 no 903 0.280037453696277 341 2839272
SGTC_3182 9108849 49.47 µM 0.582175229712767 0.265142239282938 no 904 0.280224328118108 290 17133045
SGTC_2395 5646831 180.19 µM 0.582059195602822 0.265184325507574 no 905 0.280263404390591 331 6808628
SGTC_487 nimodipine 119 µM 0.581427422568476 0.265413532644986 no 906 0.280476209980126 300 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1213 1315-0166 115 µM 0.580655945375067 0.265693560697412 no 907 0.280736179356556 299 768401
SGTC_319 1348-1596 45.5 µM 0.578444399157785 0.266497129244764 no 908 0.281482062785161 336 5380505
SGTC_280 3448-3607 3.04 µM 0.577508293653937 0.266837634447426 no 909 0.281798068817122 302 626179
SGTC_1852 st056254 31.4 µM 0.575019270472942 0.267744076240547 no 910 0.282639132127337 319 442583
SGTC_1926 methyl fluorone black 53.6 µM 0.574442795527056 0.267954235487299 no 911 0.282834100130185 287 72721 Reacts with homocysteine.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.573672651414099 0.268235128167385 no 912 0.283094669200785 325 23665772 A membrane-active detergent.
SGTC_29 0299-0004 12.984 µM 0.570762677925572 0.269297811010787 no 913 0.28408026265493 303 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1912 st060209 90.8 µM 0.570447949142199 0.269412872091557 no 914 0.284186957998278 334 688787
SGTC_730 1436-0052 41.2 µM 0.570172467016671 0.269513605286605 no 915 0.284280364162795 287 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2122 5258151 111.688 µM 0.569409488432711 0.269792695645376 no 916 0.284539139570543 309 2173356
SGTC_465 cgp-37157 41 µM 0.569214761647609 0.269863948037177 no 917 0.284605202039381 304 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3054 9094397 49.47 µM 0.567536590443586 0.270478397086182 no 918 0.285174837061256 330 2598354
SGTC_1987 st072290 61.9 µM 0.567490441620488 0.270495303982047 no 919 0.285190509397418 320 54697379
SGTC_3219 9131112 49.47 µM 0.566673490003985 0.27079468644931 no 920 0.285468017558521 297 17612988 YMR079W SEC14
SGTC_2859 9028643 45.46 µM 0.566039910822904 0.271026983548362 no 921 0.285683324895388 291 17151580
SGTC_890 0929-0006 47.2 µM 0.565982925247363 0.271047881757492 no 922 0.285702693921135 304 1378169
SGTC_818 4072-2707 53.5 µM 0.565523541453381 0.271216380032331 no 923 0.285858858292236 318 882871
SGTC_199 4063-0024 41.6 µM 0.564219818854054 0.271694859193464 no 924 0.286302270753347 310 306215
SGTC_1919 st067113 52.3 µM 0.563717404801801 0.271879362251249 no 925 0.286473235221626 321 1268243
SGTC_3060 1327-0027 12.5 µM 0.561153001476046 0.27282206592927 no 926 0.287346619560443 293 16000455 YPR107C YTH1
SGTC_202 3594-0513 34.79 µM 0.560833399709686 0.272939668686245 no 927 0.28745555773539 309 708429
SGTC_1702 st027038 51 µM 0.55849051745556 0.27380253774443 no 928 0.288254738963496 298 5521182
SGTC_3081 9117243 49.47 µM 0.557999210668311 0.273983653952085 no 929 0.288422461584544 328 45595589
SGTC_2736 butenafine 14.65 µM 0.557966047938767 0.273995881252617 no 930 0.288433784355203 326 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_932 2857-0803 154 µM 0.556641140540373 0.274484603183032 no 931 0.288886319585115 323 674898
SGTC_1647 st011722 22.4 µM 0.556348069253029 0.274592767198019 no 932 0.288986466096001 312 2854783
SGTC_3033 9090887 49.47 µM 0.556176696952546 0.274656025427407 no 933 0.289045033947229 310 19325384
SGTC_1687 st020778 55.3625 µM 0.554569490434708 0.275249639094009 no 934 0.289594581124274 301 4259299
SGTC_832 4083-0019 164 µM 0.553325629860621 0.275709485877637 no 935 0.290020226973524 317 1990758
SGTC_2355 9061122 103.12 µM 0.553311467242359 0.275714723874688 no 936 0.290025075072844 346 5302957
SGTC_3215 9129942 49.47 µM 0.552435879639286 0.276038651982266 no 937 0.290324876996635 338 17682944
SGTC_812 4251-0442 148 µM 0.552053158167501 0.276180300415604 no 938 0.290455966714126 338 5723007
SGTC_2476 5806916 10.51 µM 0.551798163274971 0.276274695967152 no 939 0.290543322914145 311 2870194
SGTC_1198 1612-1005 86.7 µM 0.551524837681344 0.276375894863529 no 940 0.290636972498843 326 6998509
SGTC_1886 st057356 49.9 µM 0.551186790833818 0.276501081971622 no 941 0.290752817063714 321 24207747
SGTC_2346 9031566 143.75 µM 0.551184297543891 0.276502005401822 no 942 0.290753671564214 333 4771086
SGTC_1913 st060213 96.1 µM 0.550346338254858 0.276812442783138 no 943 0.29104092352619 355 688959
SGTC_3009 9080819 71.4286 µM 0.550210052865582 0.276862948340304 no 944 0.291087654610381 310 17027216
SGTC_1227 3909-8010 46.6 µM 0.549139563416941 0.27725981439466 no 945 0.29145483802392 309 15982272
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.549103130676132 0.277273326118363 no 946 0.291467338443161 308 6708514
SGTC_3225 9130819 49.47 µM 0.548239165220747 0.277593837264601 no 947 0.291763846448216 329 4547121
SGTC_435 c-PAF 6.7 µM 0.548071472408354 0.277656068379667 no 948 0.291821413946768 317 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_571 k831-0106 44.2 µM 0.547325508162907 0.277932979657722 no 949 0.292077561152891 344 4783639
SGTC_2537 larixol 68.93 µM 0.54612179935642 0.278380095481309 no 950 0.292491107994655 324 6708759
SGTC_2056 5235370 200 µM 0.545987986690857 0.278429821636735 no 951 0.292537097549256 311 5511916
SGTC_1834 st055981 52.8 µM 0.545647749827862 0.278556276625613 no 952 0.292654047365486 329 471719 YDL150W RPC53
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.545552770811428 0.278591582234353 no 953 0.292686698435651 328 689007
SGTC_2994 9053520 71.4286 µM 0.543351277321192 0.279410531710832 no 954 0.293443982618519 335 4647384
SGTC_1845 st056753 3.01 µM 0.542204888759857 0.27983744758142 no 955 0.293838683929063 308 5375839
SGTC_2212 7123476 200 µM 0.540748792913083 0.280380154398984 no 956 0.294340371157801 308 1085715
SGTC_646 4092-0839 27.3 µM 0.5399280524274 0.280686280011541 no 957 0.294623325515807 350 877796
SGTC_454 lyso-paf C-16 6.67 µM 0.538689932679229 0.281148388386716 no 958 0.295050410706206 343 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1965 Pectolinarigenin 58.4 µM 0.538575917105901 0.281190961344224 no 959 0.295089754325132 328 5320438 An anti-inflammatory.
SGTC_3257 9139206 32.98 µM 0.5382414820293 0.281315856015249 no 960 0.295205172550006 319 4910041
SGTC_1231 0242-0792 125 µM 0.535889122402138 0.28219509973604 no 961 0.296017591319619 342 3707635
SGTC_1171 0368-0077 21.4 µM 0.535687960790817 0.282270349454086 no 962 0.296087112774368 344 3239779
SGTC_1493 4348-0038 111 µM 0.534918181295116 0.28255839457812 no 963 0.296353217746994 345 800424
SGTC_2971 9092186 9.93 µM 0.534298285345811 0.282790457187907 no 964 0.296567589166131 288 25236400
SGTC_2371 9071574 200 µM 0.533935488799291 0.282926315203023 no 965 0.29669308382986 330 45596039
SGTC_2037 5169046 200 µM 0.531789778196295 0.283730469024353 no 966 0.2974358015818 309 5718022
SGTC_2620 irigenin 100 µM 0.530276327096769 0.284298326719184 no 967 0.297960178725426 336 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_713 1488-1073 324 µM 0.528207195209965 0.285075557721284 no 968 0.298677767980663 348 3312542
SGTC_2560 caryophyllene 100 µM 0.526589297020172 0.285683996005232 no 969 0.299239413052275 326 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.525981946285557 0.285912560026724 no 970 0.299450375388996 349 368090
SGTC_1366 1683-0113 21.9 µM 0.524884082182546 0.286325939179059 no 971 0.299831887788006 322 708623
SGTC_1418 3966-3099 2.4 µM 0.524279021024468 0.286553884281385 no 972 0.300042243106608 337 740335
SGTC_1464 k208-0027 110 µM 0.523951149140079 0.286677439631495 no 973 0.300156258798608 344 X1464
SGTC_2745 rifampicin 24.3 µM 0.523534957658967 0.286834313743108 no 974 0.300301015370061 312 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2934 9036370 36.88 µM 0.521522745262209 0.287593345673033 no 975 0.30100133247147 338 6462800
SGTC_3174 9107204 49.47 µM 0.519283555569252 0.288439110794828 no 976 0.301781509559746 337 3938802
SGTC_1767 st044992 70.3 µM 0.518507087908828 0.288732664173526 no 977 0.302052258037848 328 9600693
SGTC_3261 9137475 49.47 µM 0.518107152834889 0.288883919535239 no 978 0.30219175496106 307 17027690
SGTC_57 miconazole 162.5 nM 0.516693365135781 0.28941891244406 no 979 0.302685114198442 325 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1457 k015-0032 57.3 µM 0.516575733760386 0.289463446423624 no 980 0.302726179422567 335 4302660
SGTC_2225 6654152 15.4 µM 0.515674078282105 0.28980491037757 no 981 0.303041031041428 348 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2423 st077119 87.2 µM 0.514136101279784 0.290387789926739 no 982 0.303578419363543 318 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2278 7948257 134.34 µM 0.513810224758199 0.290511364654949 no 983 0.303692339289631 327 1247028
SGTC_731 3966-0296 387 µM 0.512735673063609 0.290919016683363 no 984 0.304068116219838 330 660956
SGTC_882 0843-0131 351 µM 0.512543727324191 0.290991863154884 no 985 0.304135262562712 331 5425421
SGTC_1117 retinoic acid 1.10837 µM 0.511760445491392 0.291289219425075 no 986 0.304409338206109 343 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1727 st034309 9.9045 µM 0.511450949937557 0.291406751899994 no 987 0.304517663100778 372 870305
SGTC_1944 st076371 56.9 µM 0.50957552911499 0.292119425072478 no 988 0.305174435692009 325 24208455
SGTC_2014 4013930 200 µM 0.50698843639448 0.29310386768022 no 989 0.30608146611814 346 64556
SGTC_427 1354-0053 47.3 µM 0.506779939881391 0.293183271894585 no 990 0.30615461654718 353 6813657
SGTC_211 3455-0679 143.504 µM 0.50524088917017 0.293769715243881 no 991 0.306694827225023 313 748649
SGTC_2750 bromebric acid 70.15 µM 0.504873921884184 0.293909625381916 no 992 0.306823695747144 333 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1798 st045719 60.953 µM 0.50428887776444 0.294132743311719 no 993 0.307029196053433 365 3980186
SGTC_3069 9117009 49.47 µM 0.503985182268693 0.294248594335887 no 994 0.307135894855603 317 41904981
SGTC_2460 5552655 174.22 µM 0.503118425134263 0.294579352913749 no 995 0.307440506616204 318 5401989
SGTC_3068 9116768 49.47 µM 0.5029514968622 0.294643073218089 no 996 0.307499186888375 350 41904888
SGTC_2013 4024628 200 µM 0.502217000624818 0.294923522582353 no 997 0.30775744276398 352 5230760
SGTC_263 alizarin 107.927 µM 0.501801686029899 0.295082154692308 no 998 0.307903513509707 352 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2784 7567673 72.73 µM 0.501065948963197 0.295363270676412 no 999 0.308162355117531 348 3471247
SGTC_1908 st060353 56.5 µM 0.500748846984372 0.295484469386227 no 1000 0.308273945043289 357 4227716
SGTC_2612 dictamnine 15.46 µM 0.497675981765861 0.296660123954041 no 1001 0.309356219793564 322 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2565 isoliquiritigenin 100 µM 0.497405283844627 0.296763793485461 no 1002 0.309451640121917 304 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1454 4239-0054 42.6 µM 0.495797978536656 0.2973796865796 no 1003 0.310018475617074 353 1340767
SGTC_2411 st077133 39.94 µM 0.493908897852288 0.298104296827898 no 1004 0.310685260161044 350 1403142 YNL221C POP1
SGTC_1147 3809-1045 12.3 µM 0.493600370339799 0.298222717645944 no 1005 0.310794219596949 329 325925
SGTC_3320 9137005 35.139 µM 0.493585644756769 0.298228370240187 no 1006 0.310799420492133 352 4908713
SGTC_2216 7189485 200 µM 0.493149974460688 0.298395629656223 no 1007 0.310953310993383 338 731273
SGTC_2309 7664088 163.95 µM 0.492919498438855 0.298484129621013 no 1008 0.311034734716532 361 704922
SGTC_1534 6-azauridine 81.6 µM 0.492283207078168 0.298728519669667 no 1009 0.311259574928385 336 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_490 phenamil 164 µM 0.491566405647202 0.299003941337109 no 1010 0.311512948584544 343 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1935 st074532 41.6 µM 0.490630151565924 0.299363858413063 no 1011 0.311844028430736 358 2829742
SGTC_2980 9014342 25.29 µM 0.489560646501201 0.29977524040233 no 1012 0.312222414849234 353 2996599
SGTC_3149 9097855 49.47 µM 0.489064940387644 0.299965999090265 no 1013 0.312397860829755 320 25236625 YMR079W SEC14
SGTC_3328 9140624 29.0385 µM 0.488425672968968 0.300212084409973 no 1014 0.312624180468063 340 4904392
SGTC_939 1165-0479 45.3 µM 0.488228988929219 0.300287816081292 no 1015 0.312693826676163 364 1377347
SGTC_2322 7413319 38.22 µM 0.487868983495587 0.300426455756913 no 1016 0.312821322636564 339 1840400
SGTC_2380 9035439 200 µM 0.487184932053892 0.30068996661508 no 1017 0.313063641216546 339 6462575
SGTC_1411 3909-8223 150 µM 0.487116195555884 0.300716451112025 no 1018 0.313087994920604 356 X1411
SGTC_2402 5553605 200 µM 0.485671168027562 0.301273470543667 no 1019 0.313600164430693 332 6758546
SGTC_2238 6671620 73.2395 µM 0.485648595624797 0.301282175285574 no 1020 0.313608167753048 310 729941
SGTC_394 menadione 8.33 µM 0.484822532389247 0.301600813287849 no 1021 0.313901118939418 347 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_606 k015-0008 38.6 µM 0.484715441231997 0.301642132738869 no 1022 0.31393910584042 355 1970475
SGTC_3032 9089427 49.47 µM 0.484094483801574 0.301881769630922 no 1023 0.314159407965526 331 17173707
SGTC_3012 9080433 71.4286 µM 0.48380958578115 0.301991744719259 no 1024 0.314260505725716 365 17688859
SGTC_298 1391-0729 10 µM 0.482621475955876 0.302450567552847 no 1025 0.314682263746135 355 3237558
SGTC_3292 9120825 59.784 µM 0.481552902428985 0.302863494782554 no 1026 0.315061795128298 362 24824900
SGTC_288 1315-0019 35.1 µM 0.48135069977691 0.302941660034177 no 1027 0.315133634592783 356 6811474
SGTC_1296 1068-0102 11.9 µM 0.480628244742435 0.303221012396263 no 1028 0.315390368763885 358 767053
SGTC_756 0508-1999 28.3 µM 0.480213243505872 0.30338153337652 no 1029 0.315537885393928 348 6753853
SGTC_2747 doxorubicin 7.63 µM 0.480112056305281 0.303420677977664 no 1030 0.315573857926164 325 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2012 4023501 200 µM 0.479757245586891 0.303557955495698 no 1031 0.315700008634211 370 3477460
SGTC_1736 st036774 51 µM 0.478933927220489 0.303876607068698 no 1032 0.315992816987821 361 1272247
SGTC_235 0330-0087 5 mM 0.476901897809921 0.30466370772069 no 1033 0.316715990260082 345 46494818 YHR062C RPP1
SGTC_3274 9138298 49.47 µM 0.475489468257195 0.305211341698359 no 1034 0.317219069064098 342 17015756
SGTC_2790 5423970 71.43 µM 0.473972308617352 0.305800068254317 no 1035 0.317759827081952 352 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2866 9034245 58.44 µM 0.473754242858189 0.305884728947288 no 1036 0.317837583798053 361 6462273
SGTC_2328 6201408 200 µM 0.472253103178118 0.306467804747308 no 1037 0.318373069956622 356 2890418
SGTC_530 4358-1714 28 µM 0.471446893075874 0.306781157035261 no 1038 0.318660817818381 349 1564641
SGTC_1952 st077036 64.1 µM 0.470503368782017 0.30714805905736 no 1039 0.318997713982349 348 2937007
SGTC_123 0083-0120 66.675 µM 0.469046732520438 0.307714870737865 no 1040 0.319518116312861 350 16001701
SGTC_1795 st049545 62.3 µM 0.468495734993453 0.307929396722395 no 1041 0.319715060139288 321 5291882
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.468419627733672 0.307959033569362 no 1042 0.319742267262593 332 5379071
SGTC_2819 7996655 46.38 µM 0.468201755866186 0.30804388174612 no 1043 0.319820158319136 361 6456960
SGTC_84 0443-0269 128.823 µM 0.466874041410668 0.308561169487931 no 1044 0.320294999244773 346 6150058
SGTC_325 2810-4341 181 µM 0.466771227139996 0.308601242589991 no 1045 0.320331781809329 342 774970
SGTC_1559 coumarin 343 70.1 µM 0.466300322851465 0.308784812342543 no 1046 0.320500273849476 353 108770 A hepatotoxic, DNA x-linker.
SGTC_146 3448-8650 53.125 µM 0.466046201308915 0.308883894850863 no 1047 0.320591215252482 386 2891488 YIL048W NEO1
SGTC_276 colchicine 750 µM 0.466027200752119 0.30889130376574 no 1048 0.320598015334321 363 2833 A microtubule depolymerizer.
SGTC_3062 9077494 49.47 µM 0.463706964505399 0.309796620666159 no 1049 0.321428853374747 317 16459633
SGTC_2153 5569715 200 µM 0.463009366667576 0.31006903758715 no 1050 0.321678826604016 378 2054701
SGTC_2933 9026794 32.47 µM 0.461066344679551 0.31082835090521 no 1051 0.322375503416027 380 17586027
SGTC_153 4077-0274 519.67 µM 0.460045105895359 0.311227764165751 no 1052 0.32274192235038 362 3121976
SGTC_2744 captopril 92.04 µM 0.459909712369134 0.311280734176486 no 1053 0.322790514277324 328 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1828 st055811 49 µM 0.458798017491373 0.311715810272538 no 1054 0.323189609278291 384 5877589
SGTC_1066 ketoconazole 628 nM 0.458133498859815 0.311976003798524 no 1055 0.323428266652528 375 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_3202 9113761 49.47 µM 0.457700934931214 0.312145425460248 no 1056 0.32358365811527 357 4798415
SGTC_1427 4048-4900 550 nM 0.457365296889797 0.312276911687495 no 1057 0.323704251750692 362 24132586
SGTC_1938 st074717 56.4 µM 0.456088011631053 0.312777506807745 no 1058 0.324163345303329 345 17250979
SGTC_2518 prenyletin 46.28 µM 0.455921981882103 0.31284260277209 no 1059 0.324223040894635 328 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2645 abamectin 100 µM 0.453951261195749 0.313615716642181 no 1060 0.32493195350343 333 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_844 0330-0132 15.3 µM 0.453715773354745 0.313708153408031 no 1061 0.325016706263745 370 2828079
SGTC_1723 st034307 2.5525 µM 0.453159718121224 0.313926469886776 no 1062 0.325216868094296 345 867466
SGTC_1790 st045711 43.5 µM 0.45244562824592 0.314206928930454 no 1063 0.325473991243441 336 585119
SGTC_3162 9099653 49.47 µM 0.451856161477603 0.314438523069074 no 1064 0.325686303815462 329 25237511
SGTC_3100 9120536 49.47 µM 0.451059610705058 0.314751593969724 no 1065 0.325973293193906 359 16421196
SGTC_3308 9128332 17.569 µM 0.450938653155039 0.314799145957231 no 1066 0.32601688202786 353 17332805 YDL196W YDL196W
SGTC_654 1124-0271 80.9 µM 0.450710577644193 0.314888817534796 no 1067 0.326099078863889 358 5403748
SGTC_2746 daunorubicin 9.88 µM 0.45009309211011 0.315131646725755 no 1068 0.326321658775256 345 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1162 k048-0130 20.1 µM 0.449774393966342 0.315257007593068 no 1069 0.326436561474177 371 6797406
SGTC_506 n9-isopropylolomoucine 153 µM 0.449611652426929 0.315321030670639 no 1070 0.326495242289814 370 6610355
SGTC_2207 7258803 200 µM 0.449485133985188 0.315370807289732 no 1071 0.326540864865252 373 3666799
SGTC_3183 9108214 49.47 µM 0.449213024983616 0.315477875495668 no 1072 0.326638996215882 342 4974831
SGTC_3131 9127911 49.47 µM 0.448683147796581 0.315686413604857 no 1073 0.326830121571029 332 45595681
SGTC_2118 5526350 200 µM 0.448277318743836 0.315846171111125 no 1074 0.326976533813297 358 743594
SGTC_2452 5863136 48.41 µM 0.447469220127391 0.316164387349504 no 1075 0.327268153442516 343 2184096
SGTC_2619 obliquin 87.91 µM 0.447430964768754 0.316179455073183 no 1076 0.327281961320804 363 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2233 sulbentine 40.3845 µM 0.447188224968569 0.31627507065447 no 1077 0.32736958126246 348 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2456 5770359 74.46 µM 0.446764230255386 0.316442112293686 no 1078 0.327522650227697 388 3118787
SGTC_1252 0493-0875 34.8 µM 0.446038988611398 0.316727923311463 no 1079 0.327784541428177 336 3960963
SGTC_1883 5-benzylidenerhodanine 20 µM 0.442171082777936 0.318254074060386 no 1080 0.329182704882772 353 1273210
SGTC_2973 9094665 17.96 µM 0.441925911756278 0.318350915041035 no 1081 0.329271409686282 384 25237061 YIL048W NEO1
SGTC_3029 9088683 49.47 µM 0.441274595458625 0.318608241083516 no 1082 0.329507107715635 328 25236615
SGTC_2763 lisinopril 49.32 µM 0.440787171434721 0.318800872817027 no 1083 0.329683540815801 380 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1670 st016595 4.04 µM 0.440068308470617 0.319085059406607 no 1084 0.329943817152377 387 597879
SGTC_764 1951-2361 146 µM 0.439422868140823 0.319340310611985 no 1085 0.330177579765665 358 5438930
SGTC_925 2064-1272 59.6 µM 0.43937458755545 0.319359407498424 no 1086 0.330195068472806 369 6815817
SGTC_750 4073-0104 132 µM 0.439342568482096 0.319372072576171 no 1087 0.330206666966715 339 22330957
SGTC_135 0933-0004 26.348 µM 0.43851110226571 0.319701031062521 no 1088 0.330507911918836 362 21230617 YGL099W LSG1
SGTC_559 1550-0661 158 µM 0.437763524746658 0.31999692125816 no 1089 0.330778857312055 375 5830875
SGTC_1207 2099-0101 141 µM 0.436733466407476 0.320404804610476 no 1090 0.331152327815171 360 5837381
SGTC_3114 9122766 49.47 µM 0.436412606173135 0.320531903467861 no 1091 0.331268697152617 328 17176985
SGTC_1107 amlodipine 47 µM 0.436138862579588 0.320640355165176 no 1092 0.331367991146469 341 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1979 st071809 45.3 µM 0.434583096635557 0.321257008879334 no 1093 0.331932533306054 384 4976333
SGTC_3013 9080133 71.4286 µM 0.434031285177849 0.321475847088148 no 1094 0.332132861404426 354 17050193
SGTC_1548 st061468 90.8 µM 0.431030496324549 0.322666987698346 no 1095 0.333223098161813 373 390799
SGTC_2686 alizarin 95.37 µM 0.430898474405688 0.322719434739773 no 1096 0.333271096396514 331 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2248 tofa 1.1 µM 0.430706337698308 0.322795769289586 no 1097 0.33334095499974 364 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2533 agelasine 13.65 µM 0.430614505169962 0.322832256338734 no 1098 0.333374346248129 376 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_630 4356-0227 183 µM 0.428792722206089 0.32355644223691 no 1099 0.33403703783729 382 779312
SGTC_1898 st060199 18.6 µM 0.427431011854933 0.324098179371215 no 1100 0.334532711770633 347 688866
SGTC_2288 7946289 167.31 µM 0.426322237905918 0.324539564700885 no 1101 0.334936527933453 391 1246052
SGTC_3006 9075424 71.4286 µM 0.424564676838006 0.325239726932781 no 1102 0.335577023797407 371 7465181
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.424472985647672 0.325276271055509 no 1103 0.335610451322046 411 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.42408671556456 0.325430239966273 no 1104 0.33575128668758 327 3256 An antibiotic and ribosome inhibitor.
SGTC_1008 4106-0037 6 µM 0.421125733286441 0.326611488255509 no 1105 0.33683163577745 382 2905394
SGTC_3098 9119039 49.47 µM 0.418103762651602 0.327818862092899 no 1106 0.33793562703794 354 17161528
SGTC_1086 cerivastatin 2.18 µM 0.415055851950239 0.329038425601229 no 1107 0.339050508535346 350 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3177 9107506 49.47 µM 0.41364322326768 0.329604280861403 no 1108 0.339567706747356 386 8897194
SGTC_355 1311-2252 105 µM 0.411612012792317 0.330418604735892 no 1109 0.340311912641643 368 5338538
SGTC_2740 felodipine 17.08 µM 0.411217339029471 0.330576925066874 no 1110 0.340456587656539 392 3333 L-type calcium channel blocker
SGTC_2050 5263056 171 µM 0.409722946623519 0.33117666359632 no 1111 0.341004597640746 363 763468 YGL055W OLE1
SGTC_1189 1431-2119 7.28 µM 0.408030961649876 0.331856224228973 no 1112 0.341625472064273 380 3107275
SGTC_1644 st010134 20.9 µM 0.40798423800453 0.331874997951515 no 1113 0.341642623411514 396 3818134
SGTC_1467 k284-1082 293 µM 0.407919675046715 0.331900940266289 no 1114 0.341666323763627 378 3334705
SGTC_361 000s-0510 1.45 µM 0.407767792963613 0.331961971825496 no 1115 0.341722080468006 348 660
SGTC_1206 3978-0017 132 µM 0.407011659612453 0.332265879108184 no 1116 0.341999712331319 389 3873677
SGTC_1764 st044502 93.5 µM 0.406475060476296 0.332481617515496 no 1117 0.34219678897444 350 8407
SGTC_1370 2001-0092 44.6 µM 0.406208329195075 0.332588876849855 no 1118 0.342294767310348 396 790957
SGTC_254 nsc-64875 3.808 µM 0.405714013687327 0.332787689740736 no 1119 0.342476372167984 372 56993
SGTC_671 0560-0003 407 µM 0.40467646938214 0.333205141260325 no 1120 0.34285767038562 394 3238678
SGTC_1209 2323-2347 50.3 µM 0.40378400057696 0.333564387689557 no 1121 0.343185781383221 373 5412760
SGTC_1077 5-fluorocytosine 377 nM 0.403629121989813 0.333626746689328 no 1122 0.343242733648936 393 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2515 chrysin 20.77 µM 0.403208462477751 0.333796140657759 no 1123 0.343397437375486 355 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_485 niflumic acid 177 µM 0.401943812644089 0.334305602169729 no 1124 0.343862688907871 389 4488 A COX2 inhibitor.
SGTC_873 0591-4978 488 µM 0.400369721572041 0.33494014796166 no 1125 0.344442111045139 411 3305145
SGTC_1530 rhein 70.4 µM 0.400179016881928 0.335017056675129 no 1126 0.344512334178141 374 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.399990638312979 0.335093034086828 no 1127 0.344581706025923 420 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3240 9133527 49.47 µM 0.399301837938187 0.335370900555597 no 1128 0.344835406513787 396 17617455
SGTC_3176 9106582 49.47 µM 0.39908352685346 0.335458987448682 no 1129 0.344915829907951 355 17018027
SGTC_125 0133-0007 11.75 µM 0.398881971172611 0.335540321692267 no 1130 0.344990087017406 397 26541
SGTC_3288 9119690 36.221 µM 0.398308745823982 0.335771678798167 no 1131 0.345201307228423 392 17595618 YKL019W RAM2
SGTC_2848 9016370 25.97 µM 0.396592828780373 0.336464604792871 no 1132 0.34583387080718 375 7894410
SGTC_255 tunicamycin 200.472 nM 0.396069364052915 0.336676102397197 no 1133 0.346026929053526 352 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_519 k048-0011 62.8 µM 0.395873617479089 0.336755203966417 no 1134 0.346099132341641 361 6836379
SGTC_2951 9072950 58.06 µM 0.395767643517055 0.336798031263146 no 1135 0.346138224344022 384 16488155
SGTC_3093 9117344 49.47 µM 0.394552343327357 0.337289322158805 no 1136 0.346586645154047 363 24824913
SGTC_1491 4138-0063 26.5 µM 0.394131304604664 0.33745959385253 no 1137 0.346742049985959 384 23883227
SGTC_3117 9124945 49.47 µM 0.392989580751562 0.337921484267928 no 1138 0.347163588463717 362 17592065
SGTC_2987 9018338 71.43 µM 0.392877757334051 0.337966736160321 no 1139 0.347204885223033 390 5055682
SGTC_676 falcarinol 140 µM 0.392549649551901 0.338099525959548 no 1140 0.347326066986405 392 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1096 rimcazole 32.2 µM 0.392540620613958 0.338103180381641 no 1141 0.347329401912008 395 18528119 A dopamine reuptake inhibitor.
SGTC_2840 9008771 71.43 µM 0.39247416789438 0.33813007729082 no 1142 0.347353947230675 348 2992978
SGTC_2211 7117706 200 µM 0.389955985881324 0.339149925729749 no 1143 0.348284546841849 385 822771
SGTC_2263 7948595 193.29 µM 0.389478084714821 0.339343606212063 no 1144 0.348461259625155 389 2971371
SGTC_3187 9109394 49.47 µM 0.389225199048582 0.339446111145244 no 1145 0.348554782082083 367 17098090
SGTC_3312 9133330 71.43 µM 0.388135051240905 0.339888128673826 no 1146 0.348958047066049 396 17617324
SGTC_3348 9149464 3.537 µM 0.385645369785848 0.340898434051445 no 1147 0.349879663647003 351 1951442
SGTC_2005 4024620 188 µM 0.385377440914761 0.341007226989381 no 1148 0.349978896930914 390 236743
SGTC_1663 st014140 55.4 µM 0.385365932476918 0.341011900304806 no 1149 0.349983159560699 378 4207120
SGTC_1323 1348-1351 11.2 µM 0.384847417387098 0.341222482813355 no 1150 0.350175232849518 403 6989654
SGTC_1424 4048-1941 275 µM 0.382510036361426 0.342172367395189 no 1151 0.351041542970389 407 X1424
SGTC_3190 9110366 49.47 µM 0.381952163101165 0.342399228607392 no 1152 0.351248423805841 398 17123768
SGTC_2584 androsterone 48.74 µM 0.381597758930057 0.342543377915018 no 1153 0.351379873390311 361 2754130 A steroid.
SGTC_3101 9120531 49.47 µM 0.381421800788857 0.342614955132411 no 1154 0.3514451434053 422 24824904
SGTC_1747 st037496 66.6 µM 0.379473010402609 0.343408072172224 no 1155 0.352168321386008 360 723305
SGTC_1921 5740136 50 µM 0.379140335886088 0.343543532809391 no 1156 0.352291827328323 410 1774243
SGTC_2876 9059903 25.97 µM 0.378745058812341 0.343704510498406 no 1157 0.352438594820512 371 6916095
SGTC_2453 5731132 22.18 µM 0.377710765429224 0.344125863415158 no 1158 0.352822734794882 388 1362040
SGTC_1174 0739-0097 51.1 µM 0.377021855360096 0.344406620705258 no 1159 0.353078681572378 388 728447
SGTC_3150 9097574 49.47 µM 0.375315139604348 0.345102541982657 no 1160 0.353713053986168 403 17217476
SGTC_2032 5185112 25.99 µM 0.373163670227506 0.345980560341156 no 1161 0.354513316690055 376 5718189
SGTC_3333 9141820 12.094 µM 0.372701375240579 0.346169332055143 no 1162 0.354685356398469 416 1939433
SGTC_2176 5809774 33.9695 µM 0.372002146945672 0.346454924809276 no 1163 0.354945625427558 405 2870539
SGTC_1141 3253-0389 52.6 µM 0.371601682585219 0.346618529775907 no 1164 0.355094718074466 407 5402031
SGTC_2989 9073649 71.4286 µM 0.370889457984906 0.346909571370196 no 1165 0.355359933685944 414 21367202
SGTC_1205 4161-2785 76 µM 0.370540367520589 0.347052255787209 no 1166 0.35548995232114 360 3498106
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.370171580382827 0.347203014420689 no 1167 0.355627325245504 406 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.370008061820879 0.347269867861917 no 1168 0.355688241786113 378 2374 Ca(2+)-ATPase inhibitor.
SGTC_1278 0874-0585 172 µM 0.369210265009803 0.347596109732905 no 1169 0.355985502601396 373 766306
SGTC_2130 NSC 7 2.4545 µM 0.368171456317598 0.348021077434182 no 1170 0.356372696191148 370 21448
SGTC_2662 daunorubicin 22.37 µM 0.36635506590391 0.348764605715901 no 1171 0.357050072331893 370 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_976 1348-1067 47.6 µM 0.366250972471069 0.348807233359655 no 1172 0.35708890498253 378 5310671 YGL099W LSG1
SGTC_1901 st060216 58.6 µM 0.364926733906581 0.349349693065144 no 1173 0.357583048849577 373 688792
SGTC_1676 st018489 23.4 µM 0.363090847645845 0.350102252708538 no 1174 0.358268510644885 370 3696235
SGTC_1482 3346-2049 8.48 µM 0.361249619928514 0.350857593610454 no 1175 0.358956425842274 379 3826804
SGTC_2762 leflunomide 42.06 µM 0.361106571797964 0.350916302066816 no 1176 0.35900989033833 387 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2601 securinine 100 µM 0.360192336123607 0.351291598011066 no 1177 0.359351652755768 396 442872 A GABA receptor antagonist.
SGTC_3311 9131146 2.8755 µM 0.35877222179731 0.3518748459026 no 1178 0.359882747429171 385 4900406 YPR165W RHO1
SGTC_3128 9127691 49.47 µM 0.358748677978914 0.351884518406279 no 1179 0.359891554635031 410 41316314
SGTC_2950 9072895 21.46 µM 0.358575206096059 0.351955788790801 no 1180 0.359956448805679 350 17332245
SGTC_3356 9151811 4.48 µM 0.35849840331465 0.351987344636527 no 1181 0.359985181280277 393 1859254 YPR165W RHO1
SGTC_1222 0366-0074 1.18 µM 0.357755500155867 0.352292632755394 no 1182 0.360263147526006 415 286520
SGTC_2722 naftopidil 47.16 µM 0.357695751632817 0.352317189911523 no 1183 0.360285506374012 406 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_910 3454-3003 490 µM 0.356340304354565 0.35287445562879 no 1184 0.36079286456099 413 820824
SGTC_2031 5180455 200 µM 0.355867591995627 0.353068876425476 no 1185 0.360969863463241 387 29949
SGTC_275 trichlorophene 5.69 µM 0.355665148397267 0.353152150730825 no 1186 0.361045674048594 379 62616
SGTC_1794 st048918 76.9 µM 0.35183496765142 0.354729000325325 no 1187 0.362481016373146 393 672303
SGTC_1173 0443-0020 122 µM 0.351355624769522 0.354926517331324 no 1188 0.362660784529814 399 5331295
SGTC_411 enrofloxacin 100 µM 0.351284586572537 0.354955792498522 no 1189 0.362687428590877 417 71188 A bacterial gyrase inhibitor.
SGTC_953 1188-0045 9.7 µM 0.351275540387831 0.354959520534254 no 1190 0.362690821561117 401 6144426
SGTC_3151 9099821 49.47 µM 0.350937845627077 0.355098698322867 no 1191 0.362817489108932 389 17174189
SGTC_233 rapamycin 362 pM 0.349319112814836 0.355766112335586 no 1192 0.363424875594359 367 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1942 st076330 65.2 µM 0.349246730168404 0.35579596651656 no 1193 0.363452043294354 406 24208414
SGTC_460 trequinsin 123 µM 0.348552600794965 0.356082304662547 no 1194 0.363712608807888 391 5537 A vasodilator.
SGTC_372 0155-0182 15.9 µM 0.347373822208647 0.356568753369141 no 1195 0.364155248588373 387 771486
SGTC_3234 9132280 49.47 µM 0.347058224004287 0.356699031499074 no 1196 0.36427378875703 378 17612295
SGTC_1009 4106-0057 9.87 µM 0.346712448519858 0.356841785925331 no 1197 0.364403678559758 421 2928005
SGTC_1075 aripiprazole 15.2 µM 0.345541820556371 0.357325231865807 no 1198 0.364843537913243 374 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2408 sulbentine 18.36 µM 0.343801398814761 0.35804441455993 no 1199 0.365497824092948 376 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1100 amiodarone 5.07 µM 0.34355608460419 0.358145824679062 no 1200 0.365590077923607 382 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1000 4048-0884 8.67 µM 0.342648094990084 0.358521264344279 no 1201 0.365931607695437 405 13040088
SGTC_951 1171-0579 82.7 µM 0.34197665450079 0.358798982599898 no 1202 0.366184230619382 405 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_281 1672-3440 14.9 µM 0.340346863989013 0.359473399688338 no 1203 0.36679766448582 413 6833000
SGTC_222 nsc-310342 10.666 µM 0.340191947546146 0.359537527867757 no 1204 0.366855990938542 428 432556
SGTC_1529 apigenin 74 µM 0.339301387108795 0.359906255023121 no 1205 0.367191348901681 424 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_212 3807-4682 38.772 µM 0.33874279954431 0.360137598887566 no 1206 0.367401747718368 393 3125501 YBL034C STU1
SGTC_1590 st077108 57.8 µM 0.338456877338676 0.360256035866935 no 1207 0.367509459212711 389 5489485
SGTC_2946 9065502 71.43 µM 0.336888481692665 0.360905947540402 no 1208 0.368100484291548 378 16489101
SGTC_1805 st050013 60.3 µM 0.335517854868149 0.361474236899897 no 1209 0.368617239130392 415 4037144
SGTC_3104 9120930 49.47 µM 0.335384973473776 0.361529348467468 no 1210 0.368667350834676 414 17014836
SGTC_2627 acetyl isogambogic acid 100 µM 0.335003461620763 0.361687593625587 no 1211 0.368811237479292 397 6857789 A caspase activator and apoptosis inducer.
SGTC_1933 st074711 15.9 µM 0.334767822148711 0.361785345018289 no 1212 0.368900117754732 403 17250958
SGTC_1739 st037196 92.5 µM 0.334113315052805 0.362056904468849 no 1213 0.369147026454317 406 612214
SGTC_1461 k072-0203 53.8 µM 0.333449499622433 0.362332396956095 no 1214 0.369397501821495 397 5418714
SGTC_1726 st035556 14.5795 µM 0.332741138252191 0.362626455270563 no 1215 0.369664846719032 373 5919439
SGTC_3264 9137442 49.47 µM 0.332507816744193 0.362723330548717 no 1216 0.369752919128266 382 17015726
SGTC_2010 4012422 159 µM 0.332097530987331 0.36289370283518 no 1217 0.369907807211414 412 952393
SGTC_1263 0774-1208 64.8 µM 0.332066353008295 0.362906650686578 no 1218 0.369919578157559 428 906585
SGTC_129 0088-0017 176.636 µM 0.332011210586628 0.362929551075466 no 1219 0.369940396946918 410 182446
SGTC_1927 st060202 13.8 µM 0.331950050291198 0.362954951232401 no 1220 0.369963488205018 403 688887
SGTC_2843 9000894 45.46 µM 0.331211339777529 0.363261788753259 no 1221 0.370242427641577 357 2242070
SGTC_920 mycophenolic acid 780.421 nM 0.330683776731687 0.363480975876469 no 1222 0.370441678911209 382 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_414 piperonyl butoxide 100 µM 0.330113664967833 0.363717891008709 no 1223 0.370657039163062 410 5794 A potent inhibitor of cytochrome P450.
SGTC_21 0849-0113 22.993 µM 0.328667137654081 0.364319242295218 no 1224 0.371203647965702 393 1560156
SGTC_154 3389-1638 511.116 µM 0.328565460544018 0.364361524156372 no 1225 0.371242079154376 426 5238686
SGTC_1555 citronellol 128 µM 0.327021096723673 0.365003941930113 no 1226 0.371825964419153 425 8842 A terpine precursor.
SGTC_736 0958-0254 92.6 µM 0.326284933707081 0.36531030137595 no 1227 0.372104393097536 429 6812352
SGTC_1345 1488-0192 31.4 µM 0.324948993537329 0.365866481771571 no 1228 0.372609837863724 417 658348
SGTC_2058 5236698 133 µM 0.324852130479768 0.365906818908525 no 1229 0.372646493950102 379 766665
SGTC_991 3996-0057 64.7 µM 0.323535563781505 0.366455229779557 no 1230 0.373144839253905 367 715343
SGTC_1260 0700-1617 7.75 µM 0.322202253039522 0.36701089336781 no 1231 0.373649738876417 394 2853078
SGTC_3164 9100705 49.47 µM 0.321763538284591 0.367193790827301 no 1232 0.373815919353309 420 17174235
SGTC_2827 7993847 71.43 µM 0.320636702731586 0.36766369961602 no 1233 0.374242860104809 403 2985692
SGTC_503 tyrphostin 8 294 µM 0.319748549251601 0.368034213792672 no 1234 0.374579476619669 440 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1289 0976-0073 69.1 µM 0.31929593819967 0.368223078429291 no 1235 0.374751056233362 406 3391136
SGTC_968 1309-0633 340 µM 0.318740920110045 0.368454718742576 no 1236 0.374961491015876 417 3761976
SGTC_760 0568-0725 82.9 µM 0.318723168823367 0.368462128143999 no 1237 0.374968222020519 421 3916171
SGTC_2378 9074213 121.43 µM 0.318698020727433 0.368472625063321 no 1238 0.37497775784239 403 657714
SGTC_171 k064-0041 9.68 µM 0.317199793272384 0.369098168272148 no 1239 0.375546003386168 380 53325
SGTC_2932 9016711 44.54 µM 0.316570391570728 0.369361061005256 no 1240 0.375784802592821 398 7117328
SGTC_3353 9151644 39.2805 µM 0.316425241793354 0.369421696814462 no 1241 0.375839880142635 442 4909158
SGTC_419 nsc-638432 893 µM 0.316017238801945 0.369592156023217 no 1242 0.375994711735778 381 368090
SGTC_1019 4262-0212 3.4 µM 0.314914488826434 0.370053001145503 no 1243 0.376413290208704 403 4677213
SGTC_1968 st069590 43.6 µM 0.314779161868287 0.370109567876769 no 1244 0.376464667227479 412 6384066
SGTC_2651 TUB2.036 5 µM 0.314450995114703 0.37024675339814 no 1245 0.376589265159991 402 15992207 YFL037W TUB2
SGTC_1731 st035964 63 µM 0.314404040660961 0.370266383401055 no 1246 0.376607093818608 412 6739575
SGTC_2555 cholic acid 100 µM 0.313282389287393 0.37073540665952 no 1247 0.377033064259719 399 6708657 Influences liver metabolism.
SGTC_3270 9137563 49.47 µM 0.310641903603391 0.371840294420707 no 1248 0.378036433809536 421 17015724
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.30975999233695 0.37220955813663 no 1249 0.3783717388109 426 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1215 3852-0577 11.2 µM 0.304571347008127 0.374384457670306 no 1250 0.380346322772949 378 2884876
SGTC_2027 5150920 200 µM 0.303862093779348 0.374682064485871 no 1251 0.380616478934348 422 786715
SGTC_718 1130-0073 349 µM 0.302705181145666 0.375167671955905 no 1252 0.381057274477532 418 6740020
SGTC_971 1315-0384 26.7 µM 0.302276874434515 0.375347501493085 no 1253 0.381220502902944 425 6769120
SGTC_2523 spermine 47.74 µM 0.302130564261789 0.375408937724931 no 1254 0.381276266805972 398 1103 A DNA binding polyamine.
SGTC_1346 1488-2224 62.4 µM 0.301980829539581 0.375471815210719 no 1255 0.38133333847639 413 3722427
SGTC_2539 epi(13)torulosol 80 µM 0.301332795889862 0.375743979434727 no 1256 0.381580367456504 395 6708597
SGTC_1169 aniline yellow 25.8 µM 0.298492345853506 0.376937652870679 no 1257 0.382663708569529 441 6051 A DNA damaging agent.
SGTC_3136 9095672 49.47 µM 0.298087471358716 0.377107893835374 no 1258 0.382818201780812 420 17217380
SGTC_775 4577-0580 57.3 µM 0.297374831239801 0.377407601600462 no 1259 0.383090178393332 415 2006902
SGTC_575 k072-0246 11.9 µM 0.297106550011044 0.377520449035011 no 1260 0.383192581929135 420 6796779
SGTC_3022 9087993 49.47 µM 0.294493406146041 0.378620164275913 no 1261 0.384190450639647 417 17173644
SGTC_1509 1326-1131 80 µM 0.29396868295557 0.37884110761117 no 1262 0.384390916983149 412 768313
SGTC_3277 9138724 49.47 µM 0.292829716688962 0.379320824277048 no 1263 0.384826156380525 425 15943418
SGTC_1093 fluphenazine 7.97 µM 0.290310533737864 0.380382528174725 no 1264 0.385789340471975 440 6602611 An atypical antipsychotic.
SGTC_424 splitomicin 100 mM 0.290197119445952 0.380430347640471 no 1265 0.385832719896469 420 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2292 7671323 168.05 µM 0.290144859780388 0.380452382773762 no 1266 0.385852708988488 436 937504
SGTC_1710 st031758 61.5 µM 0.289827341563037 0.380586271726012 no 1267 0.385974164822161 426 5394341
SGTC_3124 9127567 49.47 µM 0.289320544024387 0.380800004343922 no 1268 0.386168046199417 414 17592030
SGTC_2222 6885208 172.143 µM 0.289185071220477 0.380857143692869 no 1269 0.38621987773628 403 609514
SGTC_1337 1486-1011 40.3 µM 0.289050507240055 0.380913902293123 no 1270 0.38627136356992 403 X1337
SGTC_1625 st003711 30.1 µM 0.287594004043944 0.381528413813792 no 1271 0.386828767572027 415 24207034 YER133W GLC7
SGTC_1820 st053765 18.6 µM 0.287569446093217 0.381538777594725 no 1272 0.38683816790868 409 3690829
SGTC_350 k064-0020 19.8 µM 0.286788619810241 0.381868340885504 no 1273 0.38713708858486 403 2790705
SGTC_1264 0783-0040 158 µM 0.285823710406156 0.382275718400269 no 1274 0.387506573544985 427 2855798
SGTC_2857 9024691 58.44 µM 0.28562752883466 0.382358560747735 no 1275 0.387581708245992 433 16478292
SGTC_1130 3454-2858 15.9 µM 0.284975539345448 0.382633917525013 no 1276 0.387831441011657 463 715628 YIL048W NEO1
SGTC_478 N-arachidonylglycine 10 µM 0.28491863362566 0.382657953514839 no 1277 0.387853239920277 414 5283389
SGTC_2914 7968218 45.32 µM 0.28481327534999 0.382702456217587 no 1278 0.387893600511801 422 2977111
SGTC_967 1306-0166 352 µM 0.282266703835303 0.383778582569259 no 1279 0.388869507209196 443 4437607
SGTC_137 0438-0332 85.389 µM 0.281514055249971 0.384096807765865 no 1280 0.389158074639179 443 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_865 0488-0499 301 µM 0.281287283045287 0.384192704004463 no 1281 0.389245031688133 425 9634651
SGTC_2461 5755302 26.15 µM 0.280280772598074 0.3846184173432 no 1282 0.389631050543952 440 2788904
SGTC_824 1304-0008 100 µM 0.27831473320499 0.385450373746565 no 1283 0.390385383637129 427 768245
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.277977829071194 0.38559299236399 no 1284 0.390514689057529 447 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_757 1066-0008 322 µM 0.277474548696835 0.385806070359135 no 1285 0.390707873029623 405 6842497
SGTC_2171 5739187 198.077 µM 0.277057859886904 0.385982513444042 no 1286 0.390867839281968 393 2262761
SGTC_2781 5567276 71.43 µM 0.27667993174912 0.386142564075236 no 1287 0.391012941338708 413 2853274
SGTC_2083 5306046 65.942 µM 0.276336946824493 0.38628783320905 no 1288 0.391144640402284 393 539837
SGTC_56 0957-0365 83.25 µM 0.276030313749763 0.386417719239975 no 1289 0.391262391681988 428 6752360
SGTC_2253 7938677 135.83 µM 0.274738682790821 0.386964977924422 no 1290 0.391758504868675 413 2301972
SGTC_919 tnp00227 403.569 nM 0.273601437659211 0.387447010115211 no 1291 0.392195464525167 439 1269246 A methoxyflavone. YNL221C POP1
SGTC_1610 st001799 48.1 µM 0.273440003605292 0.387515449562842 no 1292 0.392257502791767 411 621897
SGTC_1796 st049173 110.4 µM 0.273092167040518 0.387662925632777 no 1293 0.392391183878477 443 94134
SGTC_1813 st051246 8.6015 µM 0.272985626358773 0.387708100093591 no 1294 0.392432132299349 422 5291959
SGTC_875 0709-0210 25.7 µM 0.269874865812982 0.389027765684083 no 1295 0.393628262064383 442 6251364
SGTC_3071 9117417 49.47 µM 0.268677910024188 0.389535887681848 no 1296 0.39408877608178 439 45595590 YGL055W OLE1
SGTC_3107 9121808 49.47 µM 0.267902589561891 0.389865121322938 no 1297 0.394387150178734 389 662681
SGTC_1350 1495-0454 146 µM 0.267229509716814 0.3901510034015 no 1298 0.394646228293321 442 1069057
SGTC_175 3793-3120 23.7 µM 0.264942185096558 0.391122958552856 no 1299 0.395527000077523 446 5322297
SGTC_1800 st050079 29.0735 µM 0.264862920866304 0.391156652613957 no 1300 0.395557531663193 429 3645560
SGTC_178 4092-0806 87.505 µM 0.263729088339065 0.391638717486315 no 1301 0.395994339784991 424 2169044
SGTC_2856 9022925 19.48 µM 0.26201956631521 0.392365859313638 no 1302 0.396653178649648 415 4944862
SGTC_1195 1502-0147 41.1 µM 0.261927760188847 0.392404919528125 no 1303 0.396688568511746 421 817940
SGTC_1755 st041960 45.185 µM 0.258673831475097 0.393790046803508 no 1304 0.397943455983537 444 2257073
SGTC_322 k048-0136 19.3 µM 0.258407244228628 0.393903587084144 no 1305 0.39804631316395 420 6823282
SGTC_3322 9139058 2.11 µM 0.257329468447864 0.394362706756223 no 1306 0.398462222839775 400 4908926 YPR165W RHO1
SGTC_2127 5253358 187.912 µM 0.256371783944153 0.394770792173721 no 1307 0.398831886551336 431 20612
SGTC_491 tetrandrine 80.3 µM 0.254168786800369 0.395709963868524 no 1308 0.399682581726831 442 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2698 st077697 67.5 µM 0.253817865160156 0.395859623263482 no 1309 0.399818135458915 437 3154499
SGTC_1313 1220-0047 237 µM 0.253266964116987 0.396094599888271 no 1310 0.400030961425831 427 3528706
SGTC_2495 cafestol 54.53 µM 0.25125449201848 0.396953302838623 no 1311 0.400808678434875 431 16667697 An anti-infammatory.
SGTC_2131 toluylene red 5.2905 µM 0.2507516195468 0.39716795202103 no 1312 0.401003074333159 390 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_3186 9110464 49.47 µM 0.249882069289348 0.397539189677392 no 1313 0.401339275034984 439 17018021
SGTC_717 1532-0246 73.2 µM 0.249206046271212 0.397827868774499 no 1314 0.40160070134761 400 9561992
SGTC_743 1275-0778 158 µM 0.249044973274735 0.397896659318178 no 1315 0.401662996733635 438 2849257 YMR203W TOM40
SGTC_3122 9126309 49.47 µM 0.248690068937981 0.398048241935036 no 1316 0.401800265694547 474 17591206
SGTC_518 1021-0119 62.6 µM 0.246731821412425 0.398884901999159 no 1317 0.402557888916415 420 1097762
SGTC_1402 3909-7673 35.9 µM 0.246156005852796 0.399131007453505 no 1318 0.402780735050799 428 5328014
SGTC_2962 9082311 13.18 µM 0.244512966416517 0.399833468024981 no 1319 0.403416780471123 426 16459453
SGTC_3059 1327-0034 3 µM 0.244244309804241 0.399948359644019 no 1320 0.403520805864293 409 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3231 9132313 49.47 µM 0.243286512907434 0.40035803411176 no 1321 0.403891725858733 438 4905967
SGTC_3346 9158254 43.5805 µM 0.242924499125856 0.40051290533484 no 1322 0.404031943192069 443 17639500
SGTC_2524 avocatin b 10.57 µM 0.241427343551019 0.401153561489112 no 1323 0.404611961166737 459 6710748
SGTC_1947 st076332 61.6 µM 0.241270736761324 0.401220591359449 no 1324 0.404672644854452 457 24208416
SGTC_2161 5662504 8.5105 µM 0.239358219370749 0.402039409220582 no 1325 0.405413912279566 402 2859334
SGTC_690 glyoxal 20.3 µM 0.239033207779225 0.402178601293949 no 1326 0.405539916451359 431 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2739 tacrine 100.86 µM 0.238303449167848 0.402491178749766 no 1327 0.40582287317628 446 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2909 7941780 10.49 µM 0.23594824374678 0.403500408107002 no 1328 0.406736415901304 434 1243215
SGTC_1478 0453-0656 35.7 µM 0.235284174685422 0.40378508491165 no 1329 0.40699408858266 442 5258496
SGTC_2004 4023728 41.89 µM 0.234903366084879 0.403948355059162 no 1330 0.407141868453709 476 360084 YDR527W RBA50
SGTC_2239 6685329 187.64 µM 0.234742930093469 0.40401714635391 no 1331 0.407204132587969 390 805680
SGTC_111 0083-0039 52.457 µM 0.233695354079777 0.404466395940616 no 1332 0.407610747402733 461 759313
SGTC_522 1273-0010 11.6 µM 0.233203835184726 0.404677225690389 no 1333 0.407801563950416 455 5705015
SGTC_2435 5706476 10.6 µM 0.233022257912185 0.404755117576115 no 1334 0.407872061075243 438 5725375
SGTC_2841 9004761 38.96 µM 0.231084505487506 0.405586596988513 no 1335 0.408624576104783 399 2991039
SGTC_2945 9067681 61.76 µM 0.230528280167533 0.405825349252105 no 1336 0.408840645390405 469 16456930
SGTC_675 1309-0189 238 µM 0.229868067068084 0.40610878234107 no 1337 0.409097145350974 400 4246530
SGTC_883 0850-0245 24.6 µM 0.22972037399409 0.406172194525757 no 1338 0.409154531046769 450 6823229 YPR165W RHO1
SGTC_785 1270-0111 65.3 µM 0.228522347413178 0.406686659382581 no 1339 0.409620092487801 418 6741994
SGTC_1118 chelidonine 707.474 nM 0.228425441850148 0.406728280293321 no 1340 0.409657756243074 453 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_81 0411-0046 9.971 µM 0.22818471132442 0.406831678541714 no 1341 0.409751323267466 420 12925265
SGTC_1393 3470-5649 58.2 µM 0.228006741611957 0.406908124026934 no 1342 0.409820499754105 466 4108395
SGTC_302 1094-0063 18.9 µM 0.226948141024942 0.40736291075492 no 1343 0.410232033713799 445 5440289
SGTC_2084 5306078 60.6385 µM 0.226920028608687 0.407374989870553 no 1344 0.410242963844561 457 679340
SGTC_1201 1889-3372 45.9 µM 0.225865500759455 0.407828154387847 no 1345 0.410653015438374 437 5392199
SGTC_1655 st012546 55.1 µM 0.225829705124397 0.407843539090834 no 1346 0.410666936234651 462 720985 YLR208W SEC13
SGTC_1983 st071813 46.9 µM 0.225703578881024 0.407897748363054 no 1347 0.410715987182733 435 11838595
SGTC_1498 4478-3555 97.6 µM 0.225590915924598 0.407946172582812 no 1348 0.410759803391027 463 3437919
SGTC_2877 9040724 71.43 µM 0.223173439328808 0.408985577734079 no 1349 0.411700261494667 430 6463895
SGTC_2308 7584454 197.62 µM 0.222852379822249 0.409123667067587 no 1350 0.411825199863756 446 893577
SGTC_2899 9053889 58.44 µM 0.222699403775754 0.409189466814795 no 1351 0.411884732714121 463 6470052
SGTC_1753 st043925 64 µM 0.221427732916411 0.409736550812328 no 1352 0.4123797002818 451 670181
SGTC_1562 morin hydrate 59.1 µM 0.219279085088036 0.410661316931285 no 1353 0.41321632656699 436 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_840 0245-0196 390 µM 0.219263277444287 0.410668122300959 no 1354 0.413222483108311 427 3827528
SGTC_2656 pseudo-anisatin 100 µM 0.217479040729095 0.411436428770005 no 1355 0.413917519600644 467 6708809 A neurotoxin.
SGTC_549 1661-1316 519 µM 0.215987457565017 0.412078977170548 no 1356 0.41449876212116 460 2857282
SGTC_3327 9140648 26.9345 µM 0.215893843340261 0.412119312451268 no 1357 0.41453524812133 468 8029710
SGTC_998 3996-0085 177 µM 0.215341768277097 0.412357202248311 no 1358 0.414750433515843 441 715391
SGTC_2298 7976326 193.81 µM 0.214676131514544 0.412644068728785 no 1359 0.415009916504228 453 2235818
SGTC_1114 scopoletin 1.73284 µM 0.21449887581196 0.412720467695523 no 1360 0.415079021768042 470 5280460 A coumarin with genotoxic properties.
SGTC_2276 7947513 42.08 µM 0.214154240326259 0.412869018471037 no 1361 0.415213389568655 446 2105100
SGTC_1445 4239-0156 97.7 µM 0.21395497901348 0.412954913238944 no 1362 0.415291082856656 466 4008346
SGTC_2155 5570423 76 µM 0.213866770617064 0.412992938206502 no 1363 0.415325476944728 456 797402
SGTC_674 0498-0004 451 µM 0.213524043595791 0.413140689073006 no 1364 0.415459118716149 432 4231473
SGTC_3026 9090633 49.47 µM 0.213437994920073 0.41317778690345 no 1365 0.415492673771279 429 25236842
SGTC_3157 9099274 49.47 µM 0.21321374112502 0.413274472210834 no 1366 0.415580125408748 471 17217662
SGTC_54 0159-0055 9 µM 0.211929413088934 0.413828301562299 no 1367 0.416081051713976 455 3319099
SGTC_228 caffeine 993.056 µM 0.211916158657253 0.413834018048608 no 1368 0.416086222050594 438 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1380 2291-0730 164 µM 0.211273099168533 0.414111384235561 no 1369 0.416337086448122 418 2999191
SGTC_3324 9138759 60.749 µM 0.210907072071245 0.414269279192863 no 1370 0.416479892769504 446 45595710
SGTC_76 0433-0009 400.328 µM 0.210625547547893 0.414390731276889 no 1371 0.416589737717247 473 2841569
SGTC_1342 1486-1464 234 µM 0.210352780958718 0.414508412921373 no 1372 0.416696171716155 453 3253938
SGTC_311 1315-0136 58 µM 0.209545329715513 0.41485682234298 no 1373 0.417011276367849 459 6759207
SGTC_2337 9009472 200 µM 0.20918754430737 0.415011225613372 no 1374 0.41715091776636 469 5742383
SGTC_148 3253-0744 288.01 µM 0.209071582635934 0.415061272007765 no 1375 0.417196179122223 456 6893655
SGTC_2113 5491891 107.031 µM 0.208474798276711 0.415318852214998 no 1376 0.417429129199707 444 789979
SGTC_3044 9093193 49.47 µM 0.207865521079505 0.415581862049203 no 1377 0.417666985658233 468 25236277
SGTC_1961 st076550 68.7 µM 0.207126636303576 0.415900870994972 no 1378 0.417955480187641 428 1579337
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.206901554686233 0.415998059618125 no 1379 0.418043371162742 457 4213774
SGTC_1511 0906-3109 28.5 µM 0.206682235675267 0.416092764931137 no 1380 0.418129015864351 430 2882180
SGTC_1456 k015-0012 13 µM 0.206575864979048 0.416138699184311 no 1381 0.418170555324051 461 2989616
SGTC_2729 fluphenazine 10.66 µM 0.206198955989461 0.416301469702272 no 1382 0.418317751662439 461 3372 An atypical antipsychotic.
SGTC_945 3381-0768 11.3 µM 0.205800487951466 0.416473566240807 no 1383 0.418473380014597 477 1126236 YIL048W NEO1
SGTC_747 3448-8087 38.7 µM 0.205081473158946 0.416784145962735 no 1384 0.418754235536216 457 5168703
SGTC_442 cape 100 µM 0.204679061320188 0.416957991159522 no 1385 0.418911440355588 463 5281787
SGTC_3236 9132701 49.47 µM 0.201381038279569 0.418383372957945 no 1386 0.420200320378609 470 24282524
SGTC_2485 5633444 17.78 µM 0.200460738102708 0.418781312253621 no 1387 0.420560130599155 432 5724239
SGTC_2778 tioconazole 65.09 nM 0.198975707787826 0.419423616893993 no 1388 0.421140873506918 461 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_946 3434-1334 87.4 µM 0.196626823316451 0.420439993199767 no 1389 0.422059789196786 436 4047976
SGTC_1885 st057546 99.9 µM 0.194617806478271 0.421309728103931 no 1390 0.422846081024948 426 702008
SGTC_2433 5607874 27.82 µM 0.194227673274012 0.421478667556224 no 1391 0.422998807654755 473 2252428
SGTC_2447 5741742 33.78 µM 0.192311957743569 0.422308439390519 no 1392 0.423748926148541 449 1776504
SGTC_3284 9108171 64.8615 µM 0.190592735640224 0.423053395987895 no 1393 0.424422340992398 473 8687505
SGTC_1080 nisoldipine 24.4 µM 0.188692273444498 0.423877205951138 no 1394 0.425167003851946 476 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2281 7943571 200 µM 0.188663551282392 0.42388965895959 no 1395 0.425178260183927 474 1244024
SGTC_1476 4112-3294 3.34 µM 0.18826015037537 0.424064568681399 no 1396 0.425336361078046 472 704369
SGTC_652 0437-0092 114 µM 0.186717864321835 0.424733422767577 no 1397 0.425940924361763 437 3091274
SGTC_2228 7354201 200 µM 0.186542465207147 0.424809503104091 no 1398 0.426009690406609 478 753451
SGTC_901 1112-0062 60.1 µM 0.18382810365076 0.425987227814485 no 1399 0.427074154152214 476 1908457
SGTC_1513 0337-0559 19 µM 0.183494344346124 0.426132087265873 no 1400 0.427205077998498 453 775073
SGTC_1116 jasmonic acid 1.58368 µM 0.181603139575527 0.426953102675031 no 1401 0.427947092399154 476 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2502 avocadyne acetate 18.59 µM 0.181456037741035 0.427016976272518 no 1402 0.428004818537127 435 3952079
SGTC_594 1487-1584 10.8 µM 0.181449376390862 0.427019868765771 no 1403 0.428007432640386 456 5013332
SGTC_2198 6589944 200 µM 0.18143723849583 0.427025139295884 no 1404 0.428012195903728 432 5290268
SGTC_737 1950-0117 57.9 µM 0.180480388879598 0.4274406645043 no 1405 0.42838772449946 445 5393513
SGTC_917 harmaline 728.087 nM 0.18031570045892 0.427512190866872 no 1406 0.428452365252741 443 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_557 1315-0110 16.2 µM 0.179097507656833 0.428041341978862 no 1407 0.428930569484783 470 6833801
SGTC_2878 9043973 25.97 µM 0.176932708456679 0.428981992949377 no 1408 0.429780623144277 452 6465167
SGTC_625 k213-0058 121 µM 0.176444138996352 0.429194342695521 no 1409 0.429972515335455 465 3655420
SGTC_659 k018-0002 107 µM 0.176076926055994 0.429353960054541 no 1410 0.430116754021946 457 6797879 YHR007C ERG11
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.175395580632659 0.429650152739481 no 1411 0.430384406453011 482 1241132 A phosphatase inhibitor.
SGTC_830 4076-0286 57.8 µM 0.173038244814526 0.430675232066203 no 1412 0.4313106830081 453 6866659
SGTC_2785 7756463 72.73 µM 0.172611329621057 0.430860924837876 no 1413 0.431478472914431 489 2201551
SGTC_1007 4101-0031 70 µM 0.17259188526821 0.430869382797082 no 1414 0.431486115397009 471 1146276
SGTC_3199 9111318 49.47 µM 0.171375583001955 0.431398516242833 no 1415 0.431964226343139 466 8548020
SGTC_1320 1313-0481 95.3 µM 0.171323070851988 0.431421363619202 no 1416 0.431984870364222 472 6813365 YLR208W SEC13
SGTC_2016 5121758 140 µM 0.16856827980805 0.432620258516383 no 1417 0.433068116253743 488 2795203
SGTC_2334 9017922 200 µM 0.168019491631926 0.432859167568522 no 1418 0.433283972480637 472 3163164
SGTC_2329 6138490 200 µM 0.16693292666751 0.433332264307326 no 1419 0.433711412455548 459 720019
SGTC_934 2950-0684 338 µM 0.165653911300674 0.433889277463416 no 1420 0.434214659134931 485 1121253
SGTC_1522 st012842 45.6 µM 0.165315053888885 0.434036872434321 no 1421 0.434348005275735 498 3491067 YOR116C RPO31
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.164256380368658 0.434498054419401 no 1422 0.434764659326299 465 688664
SGTC_3142 9086498 49.47 µM 0.164049856092963 0.434588031448245 no 1423 0.434845947968567 481 25236367
SGTC_639 0833-0042 114 µM 0.16371530107134 0.434733795190579 no 1424 0.434977635781471 485 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_982 1491-0518 27.5 µM 0.162995394252857 0.435047484604433 no 1425 0.435261030515544 444 3091256
SGTC_2163 5671233 125 µM 0.161401823072431 0.435742006291375 no 1426 0.435888465447501 464 701023
SGTC_1194 1488-0194 225 µM 0.161010103679721 0.435912758696861 no 1427 0.436042721442544 463 1391452
SGTC_1496 4469-0713 57.4 µM 0.160010970746681 0.436348339668987 no 1428 0.436436216082339 476 746691
SGTC_2139 5578692 56.4705 µM 0.159311970552134 0.436653121009602 no 1429 0.436711545035169 479 650991 YMR113W FOL3
SGTC_2166 5933061 31.504 µM 0.159121013275232 0.436736389644437 no 1430 0.43678676647102 456 2877375
SGTC_2519 cryptotanshinone 88.04 µM 0.158857938440552 0.436851110378072 no 1431 0.436890400026449 460 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_71 0417-1750 47.813 µM 0.158183975952285 0.437145033739285 no 1432 0.437155915058077 500 6811472
SGTC_2229 7354935 190 µM 0.157557071851594 0.437418465507025 no 1433 0.437402916328283 481 318112
SGTC_161 4065-0411 162.148 µM 0.156797152981509 0.43774995333318 no 1434 0.437702358345046 475 1906281 YLR208W SEC13
SGTC_1627 st003713 25.6 µM 0.154413566916641 0.438789991157682 no 1435 0.438641828549768 462 16195070 YER133W GLC7
SGTC_2820 7989630 71.43 µM 0.153350649915167 0.439253913906162 no 1436 0.439060880066909 481 2984098
SGTC_1127 asiatic acid 681.4 nM 0.151311876754881 0.440143993671096 no 1437 0.439864850428367 446 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2060 5238662 140 µM 0.151090187493681 0.440240796237945 no 1438 0.439952286443107 453 790130
SGTC_1857 st056007 79.3 µM 0.149267344712628 0.441036891497967 no 1439 0.440671340853287 462 619834
SGTC_1105 epirubicin 18.1 µM 0.147995088222816 0.44159266907053 no 1440 0.441173322293888 479 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1995 st072814 61.1 µM 0.147879187749408 0.441643305225925 no 1441 0.441219056687158 460 5769371
SGTC_988 1497-1057 103 µM 0.147778359744306 0.441687357094741 no 1442 0.441258844113394 490 3533044
SGTC_2982 9019404 25.97 µM 0.147141651076678 0.441965552464267 no 1443 0.4415101074211 411 22333232
SGTC_1048 3161-0300 24.5 µM 0.147078040644288 0.44199334717089 no 1444 0.441535211197812 457 2165101
SGTC_1975 st070967 30.8 µM 0.146930294182971 0.442057906386713 no 1445 0.441593520058072 507 261391
SGTC_262 fenpropimorph 62.5 µM 0.146805046654084 0.442112635686287 no 1446 0.441642950596508 485 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2227 7312221 64.1025 µM 0.146527699199588 0.442233831884037 no 1447 0.441752412548633 495 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_643 k048-0106 28.4 µM 0.145471302277906 0.442695509090281 no 1448 0.442169386086165 495 6763920
SGTC_2851 9015922 71.43 µM 0.145331738564598 0.442756508461341 no 1449 0.442224478492365 495 2996893
SGTC_3296 9122258 64.045 µM 0.145135926940997 0.442842094498069 no 1450 0.442301776495696 478 4730474
SGTC_3018 9082602 49.47 µM 0.144407298742131 0.443160589283898 no 1451 0.442589426828945 480 17332089
SGTC_3185 9108267 49.47 µM 0.144385861611873 0.443169960346123 no 1452 0.442597890311665 473 4910486
SGTC_1507 4075-3230 155 µM 0.144144275425633 0.443275569923587 no 1453 0.442693271516781 475 659771
SGTC_1803 st050068 52.4 µM 0.143520786030659 0.443548147368919 no 1454 0.442939448152241 482 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_568 1193-0097 7.48 µM 0.143392772796297 0.443604115576395 no 1455 0.442989995233008 456 3646150
SGTC_83 0170-0301 39.027 µM 0.143057003959656 0.44375092120855 no 1456 0.443122580732283 466 3089716
SGTC_2983 9022671 12.99 µM 0.14264739207138 0.443930023122491 no 1457 0.443284333360538 485 6405161
SGTC_38 0929-0051 58.268 µM 0.142452603152826 0.444015198176844 no 1458 0.443361257344862 486 1379719
SGTC_261 5-fluorouridine 15.376 µM 0.142325788208597 0.444070651744822 no 1459 0.443411338911868 458 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3095 9117207 49.47 µM 0.141754769423411 0.444320360070545 no 1460 0.443636855978806 497 17015229
SGTC_2347 9049783 174.81 µM 0.141424185818753 0.444464935437893 no 1461 0.44376742438355 477 6467988 YPL169C MEX67
SGTC_533 1222-0222 6.71 µM 0.138747757576257 0.445635698265399 no 1462 0.444824738980718 485 3982874
SGTC_3194 9111903 49.47 µM 0.138587153727705 0.44570596716002 no 1463 0.444888197591769 493 17087251
SGTC_923 1900-2434 73.3 µM 0.138143619348148 0.445900035313313 no 1464 0.445063456487723 516 5910570
SGTC_2697 mebhydrolin 72.4 µM 0.136811597123427 0.446482938425795 no 1465 0.445589858332263 482 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1671 st016596 74.5 µM 0.136517352891057 0.446611717592657 no 1466 0.44570615367561 489 2829167
SGTC_3331 9141060 1.957 µM 0.135858987391817 0.446899878738605 no 1467 0.44596637905187 459 4906567 YPR165W RHO1
SGTC_636 0kpi-0074 126 µM 0.135736463609139 0.446953509486189 no 1468 0.446014810342745 477 616434
SGTC_455 paf C-16 10 µM 0.135578806060013 0.44702252030918 no 1469 0.446077130519577 478 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2202 7226349 200 µM 0.13458966705032 0.447455528784847 no 1470 0.446468155884122 459 844334
SGTC_1328 1441-0025 69.2 µM 0.134126274100053 0.447658406656072 no 1471 0.446651361814854 463 4562601
SGTC_3109 9122853 49.47 µM 0.133893705874244 0.447760232416873 no 1472 0.446743313727539 502 1234709
SGTC_2837 9008476 45.46 µM 0.131824287885249 0.448666440222326 no 1473 0.447561637621787 494 2992805
SGTC_1094 duloxetine 25.4 µM 0.130614198638766 0.449196468388848 no 1474 0.448040255033453 480 60834 A selective serotonin reuptake inhibitor.
SGTC_117 lucigenin 22.078 µM 0.129842956510912 0.449534325594286 no 1475 0.448345338094061 486 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_63 0099-0242 26.702 µM 0.129753172492569 0.449573659564467 no 1476 0.448380856274403 483 3898502 YLR359W ADE13
SGTC_1706 st031321 9.9705 µM 0.127548558635759 0.450539645382215 no 1477 0.449253121378309 468 6103185
SGTC_2187 6125751 200 µM 0.127478823971038 0.450570205520793 no 1478 0.449280716227499 486 874498
SGTC_668 1682-0499 62.6 µM 0.127460882343101 0.450578068209229 no 1479 0.449287815986082 485 682214
SGTC_2885 9057732 51.95 µM 0.126929811239477 0.45081081208295 no 1480 0.449497975754725 473 6471414
SGTC_62 0180-0423 3.232 µM 0.125745894304712 0.451329728822499 no 1481 0.449966535884777 512 30102 YGL099W LSG1
SGTC_1197 1601-0112 267 µM 0.123665822872027 0.452241635505175 no 1482 0.4507899366416 507 7350313
SGTC_371 0195-0006 7.36 µM 0.12288577312821 0.452583675805263 no 1483 0.451098775816682 483 3928593
SGTC_2863 9028737 58.44 µM 0.122871698139736 0.45258984780394 no 1484 0.451104348692525 497 6460917
SGTC_299 1273-0059 1.44 µM 0.122651256431103 0.452686514807333 no 1485 0.451191632029576 490 2848077
SGTC_831 k061-1017 217 µM 0.122374646123402 0.452807816552321 no 1486 0.451301158519411 496 1240153
SGTC_1415 3966-0071 78.1 µM 0.121158447387231 0.453341207524716 no 1487 0.451782767886455 493 2893185
SGTC_462 ag-879 158 µM 0.120795894963554 0.453500229276105 no 1488 0.451926350820278 504 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2330 7979373 200 µM 0.120667644917856 0.453556483746582 no 1489 0.451977143651469 479 1863007
SGTC_1131 3454-3128 32.3 µM 0.12063953785684 0.453568812504807 no 1490 0.451988275426661 471 710982
SGTC_2043 5101342 149 µM 0.120419662780285 0.453665259089313 no 1491 0.452075358046711 480 678451
SGTC_91 0417-1751 58.384 µM 0.120228205498301 0.453749242643282 no 1492 0.452151187535708 515 6795624
SGTC_3249 9135183 49.47 µM 0.119091959144783 0.454247704390695 no 1493 0.452601250539946 489 4902779
SGTC_144 4161-2749 112.381 µM 0.119074767254974 0.454255246884016 no 1494 0.452608060653489 482 797501 YMR168C CEP3
SGTC_1662 st014054 52 µM 0.118912449981835 0.454326460167401 no 1495 0.452672359045437 490 2838777
SGTC_2404 5161160 200 µM 0.117265027549518 0.455049314725681 no 1496 0.453325018878047 498 2831543
SGTC_3143 9086658 49.47 µM 0.117030489992969 0.455152237068012 no 1497 0.453417945985664 464 25236626
SGTC_1623 st003709 20.3 µM 0.116323224662354 0.455462625194824 no 1498 0.453698189967665 495 16192618
SGTC_3014 9081533 49.47 µM 0.115753679160346 0.455712593823646 no 1499 0.453923881162454 504 21367265
SGTC_36 0335-0881 14.2 µM 0.11574240607973 0.455717541659169 no 1500 0.453928348445032 492 23828853
SGTC_1060 3448-7350 82 µM 0.114541176325574 0.456244809173007 no 1501 0.454404403589665 470 570178
SGTC_43 0570-0105 72.5 µM 0.113911834477188 0.45652108316106 no 1502 0.454653842039687 513 1114046 YDL195W SEC31
SGTC_1602 st001878 87.6 µM 0.113880975880233 0.456534630279478 no 1503 0.454666073246879 511 595405 YLR310C CDC25
SGTC_1039 k821-0043 94 µM 0.113420839451227 0.456736639054348 no 1504 0.454848459411697 484 15992768
SGTC_1369 1866-0067 208 µM 0.11305645357072 0.456896619425698 no 1505 0.454992899294237 486 3531355
SGTC_3247 9135149 49.47 µM 0.112577799304902 0.457106778924328 no 1506 0.455182643363243 505 8934436 YOR116C RPO31
SGTC_382 3229-0966 23.2 µM 0.112251469958581 0.457250065029291 no 1507 0.455312009942439 503 5722370
SGTC_656 4090-1979 187 µM 0.112068566745774 0.457330377396938 no 1508 0.455384520244686 496 22330961
SGTC_2420 aureobasidin a 50 nM 0.111091143998581 0.457759590869298 no 1509 0.455772035669182 452 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2712 st079126 47.7 µM 0.111044621322478 0.457780021500603 no 1510 0.455790481406079 484 3152970
SGTC_2921 7974240 10.71 µM 0.11069031753521 0.457935619173623 no 1511 0.455930962141509 485 2979074 YDR527W RBA50
SGTC_2923 7992654 58.14 µM 0.109640674344014 0.45839662303199 no 1512 0.456347175816705 505 2985126
SGTC_1787 fluconazole 80 µM 0.10892110204153 0.458712691949374 no 1513 0.456632534606594 492 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1172 0370-0043 85 µM 0.108052503785597 0.459094254605623 no 1514 0.456977021985815 486 376585
SGTC_2900 5328528 85.29 µM 0.107615118922652 0.459286405741175 no 1515 0.457150501738652 510 795359
SGTC_1686 st019653 115.5 µM 0.107079755677922 0.459521613505848 no 1516 0.457362853722159 516 97252
SGTC_2889 9059656 51.95 µM 0.106158717332642 0.459926297798443 no 1517 0.457728212297976 483 3949838
SGTC_1565 sinapyl alcohol 95.1 µM 0.106115160866195 0.459945436597486 no 1518 0.457745491215486 499 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2325 6158266 200 µM 0.106109891124047 0.459947752139089 no 1519 0.457747581735752 488 3623240
SGTC_842 0271-0008 11.1 µM 0.105513525952455 0.460209805665141 no 1520 0.457984168871028 492 1221709
SGTC_1642 st009582 77.7 µM 0.104794287632013 0.46052587483389 no 1521 0.458269521450665 498 6739311
SGTC_1294 1000-1494 117 µM 0.104685942525184 0.460573489240831 no 1522 0.458312508452481 483 712797 YDL207W GLE1
SGTC_310 1273-0058 1.06 µM 0.10225328266701 0.461642717448066 no 1523 0.459277817949328 487 2734232
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.102169195175747 0.461679681467902 no 1524 0.459311189231579 466 4174840
SGTC_1115 galangin 695.678 nM 0.101032561355559 0.462179366671349 no 1525 0.459762306095758 516 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2748 diazoxide 86.69 µM 0.100547049794103 0.462392824755535 no 1526 0.459955015863997 511 3019 A potassium channel activatior.
SGTC_2976 9009005 19.48 µM 0.100214879624085 0.46253887161662 no 1527 0.460086866625869 514 2993148
SGTC_3106 9121286 49.47 µM 0.100004058195239 0.462631567112361 no 1528 0.460170551812359 467 15943471
SGTC_1250 0485-0349 40.2 µM 0.0978562554710965 0.463576043378702 no 1529 0.461023218142047 489 6842794 YDL195W SEC31
SGTC_688 0527-0193 473 µM 0.0974680525849004 0.46374677405123 no 1530 0.46117735187447 517 4007154
SGTC_221 trifluoperazine 10.304 µM 0.097017115501924 0.46394510344913 no 1531 0.461356401180842 518 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1410 3909-8106 77.9 µM 0.0950722072306656 0.464800607497999 no 1532 0.462128736738513 516 1039210
SGTC_634 1611-4317 11.2 µM 0.0923062970258675 0.46601752384171 no 1533 0.463227342714606 496 2843522
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0922819331762734 0.466028244623036 no 1534 0.463237021174866 489 23847180
SGTC_3224 9130643 49.47 µM 0.0912390202724917 0.466487178741848 no 1535 0.463651335272186 481 17644395
SGTC_1964 st076914 61 µM 0.0910102198843307 0.466587868399385 no 1536 0.463742235233214 511 24208661
SGTC_1867 st057372 64 µM 0.0905798555531418 0.466777267385959 no 1537 0.463913219530147 476 688837
SGTC_871 0574-0004 149 µM 0.0880819142134336 0.467876733296526 no 1538 0.464905785434663 516 9551173
SGTC_179 1273-0063 6.77 µM 0.0880633452626357 0.467884907326258 no 1539 0.464913164698973 510 3108139
SGTC_1450 4112-4260 37.6 µM 0.0879474892382299 0.467935907314046 no 1540 0.464959205926276 514 1633175
SGTC_810 3825-7150 143 µM 0.0863945434854296 0.468619566730292 no 1541 0.465576392190946 489 22330411 YGL099W LSG1
SGTC_2048 5246248 200 µM 0.0863483743770636 0.46863989336503 no 1542 0.465594742425866 521 677046
SGTC_3214 9129694 49.47 µM 0.085357475259422 0.469076171017256 no 1543 0.46598859977844 507 17158655
SGTC_754 3474-0146 171 µM 0.0850471239548219 0.469212821588085 no 1544 0.466111963446427 511 24762078
SGTC_1824 st053723 68.6 µM 0.0847734710107689 0.469333316538169 no 1545 0.46622074233322 494 675225
SGTC_979 1426-2828 121 µM 0.0842988142653278 0.469542324199685 no 1546 0.466409427563687 509 747872
SGTC_1677 st019204 53.9 µM 0.0840281078593152 0.469661529286413 no 1547 0.466517041975833 486 3945625
SGTC_2821 7996764 71.43 µM 0.0831861245937653 0.470032312461248 no 1548 0.466851772734069 501 2987135
SGTC_1645 Cervolide 78 µM 0.0831798279890877 0.470035085387895 no 1549 0.466854276040201 501 23173 A fragrance.
SGTC_2362 9071156 126 µM 0.0830848352421228 0.470076918890639 no 1550 0.466892041937785 498 653133
SGTC_3179 9107801 49.47 µM 0.0827218668723449 0.470236768219833 no 1551 0.467036348605699 485 4818259
SGTC_2572 astragaloside iv 100 µM 0.0824794638327511 0.47034352389505 no 1552 0.467132724086729 498 45006101 An anti-inflammatory agent.
SGTC_1874 staurosporine 7.6 µM 0.0823728334649548 0.470390485190069 no 1553 0.467175119186267 518 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_784 4579-0127 173 µM 0.0822484899319368 0.470445248095911 no 1554 0.467224557322073 516 1948547
SGTC_2126 5251174 33.877 µM 0.0821534141612604 0.470487121382333 no 1555 0.467262359137473 484 790722
SGTC_192 3455-0609 60.9 µM 0.0816681795025618 0.470700833582748 no 1556 0.467455291442077 492 3769639
SGTC_645 0845-0943 5.41 µM 0.0807795710006099 0.471092225807086 no 1557 0.467808627473114 501 1885106
SGTC_303 1348-1668 34.2 µM 0.0806694745499271 0.471140720311736 no 1558 0.467852406726929 502 5380509
SGTC_848 0368-0089 85.6 µM 0.0794497192511612 0.471678017956917 no 1559 0.46833746167451 524 762535
SGTC_1238 0333-0287 48.8 µM 0.0788838097714342 0.471927316531293 no 1560 0.468562520519395 511 7226
SGTC_102 gallobenzophenone 83.616 µM 0.0772341766414242 0.472654087365903 no 1561 0.469218626904107 509 70837
SGTC_1741 st038134 10.228 µM 0.0769020176419744 0.472800436128841 no 1562 0.469350746228207 512 1272587
SGTC_3209 9113616 49.47 µM 0.0759963672104808 0.473199482963262 no 1563 0.469710994193815 513 16649353
SGTC_2272 7805186 180 µM 0.0759481140612511 0.473220744978383 no 1564 0.469730188941253 521 2956062 YPR165W RHO1
SGTC_1788 fluconazole 20 µM 0.0750032836236946 0.473637085414609 no 1565 0.470106049650074 518 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1399 3562-5772 25 µM 0.0737513199374763 0.474188808696877 no 1566 0.470604131268969 515 23847490
SGTC_2247 cerulenin 830 nM 0.0735778751783864 0.474265247359675 no 1567 0.470673138230161 524 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1229 0139-0193 12.2 µM 0.0735377753333673 0.474282919856397 no 1568 0.470689092532937 492 3090752
SGTC_834 0312-0008 75.7 µM 0.0734344032208298 0.474328477455789 no 1569 0.470730220838518 515 6385573 YIL048W NEO1
SGTC_2342 7990637 118.86 µM 0.0733742945121567 0.474354968395778 no 1570 0.470754136226527 510 2033102 YER133W GLC7
SGTC_2949 9072542 2.23 µM 0.0732401199722652 0.474414101828186 no 1571 0.470807520488431 497 16457352
SGTC_829 1635-0120 117 µM 0.0732264219689416 0.474420138846924 no 1572 0.470812970566811 510 285054
SGTC_3217 9129673 49.47 µM 0.0729584803664976 0.474538227928395 no 1573 0.470919578642527 489 17248312
SGTC_89 0302-0250 142.109 µM 0.0726216645433495 0.474686674906383 no 1574 0.471053593212727 523 4203518 YLR208W SEC13
SGTC_364 0083-0097 67.7 µM 0.0724605004752022 0.474757707014621 no 1575 0.471117719428601 505 5207356
SGTC_1281 0884-0031 11.8 µM 0.0707615645756078 0.475506551323898 no 1576 0.471793761067265 511 1548255
SGTC_345 1362-0200 395 µM 0.0707501307570584 0.475511591333344 no 1577 0.471798311097032 489 1419823
SGTC_2303 7774051 200 µM 0.070491490556948 0.475625600576838 no 1578 0.471901236627512 516 2953184
SGTC_2416 tofa 880 nM 0.0702721107200281 0.475722305319202 no 1579 0.471988540018803 476 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3048 9093155 49.47 µM 0.0694476470310002 0.476085749583604 no 1580 0.472316651797261 518 25236002
SGTC_2367 9070478 135.38 µM 0.0673876836156745 0.476993919404952 no 1581 0.473136536975916 525 572802
SGTC_2320 7373003 200 µM 0.0671776601612573 0.477086518600334 no 1582 0.473220134775434 509 5415828
SGTC_1831 st055328 12 µM 0.0666641180176705 0.477312944176308 no 1583 0.473424550206597 511 1103068
SGTC_2486 5283202 22.39 µM 0.0657205834539134 0.477728976504456 no 1584 0.473800142306525 508 1377751
SGTC_2796 7949634 45.45 µM 0.0649643436310156 0.478062442579973 no 1585 0.474101194959484 520 2971588
SGTC_18 0111-0177 500 nM 0.0639775570549766 0.478497591955179 no 1586 0.474494048532897 513 721752
SGTC_2552 juarezic acid 87.02 µM 0.0634716775051554 0.478720682758475 no 1587 0.474695455916273 504 1549512
SGTC_3152 9099253 49.47 µM 0.0629816532830778 0.478936787785019 no 1588 0.474890556935925 510 25236131
SGTC_854 0422-0053 192 µM 0.0629614915875757 0.478945679404556 no 1589 0.474898584356872 518 3596728
SGTC_186 3455-3465 67.277 µM 0.0623734698384805 0.479205010681305 no 1590 0.475132710906922 516 755278
SGTC_543 3844-1095 191 µM 0.0617183374646537 0.479493949668384 no 1591 0.475393568311278 526 4230703
SGTC_1842 st055362 61.2 µM 0.0606025784606928 0.47998606772873 no 1592 0.475837859993046 507 676032
SGTC_2382 9035899 200 µM 0.0601196860852781 0.480199062345967 no 1593 0.476030155546154 524 6462679
SGTC_101 0490-5701 117.494 µM 0.0599372894095431 0.480279515515345 no 1594 0.476102790307095 527 4661669
SGTC_2197 6588183 93.1375 µM 0.0596530371424941 0.480404897667083 no 1595 0.476215988006333 513 884136
SGTC_1696 st025591 34.7925 µM 0.0595288837949373 0.480459661652403 no 1596 0.476265430161327 510 2787147
SGTC_1827 berberine 7.24 µM 0.0590114570852715 0.480687902299201 no 1597 0.476471491290928 524 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3096 9117468 49.47 µM 0.0587104435876219 0.480820684437865 no 1598 0.476591370454322 535 41316311
SGTC_468 gf-109203x 121 µM 0.0585406443628355 0.480895586683935 no 1599 0.476658994234354 531 2396 A protein kinase C inhibitor.
SGTC_2961 9083290 32.55 µM 0.0585011271056629 0.48091301872916 no 1600 0.476674732366814 528 17741490
SGTC_1640 st009078 66.4 µM 0.0576724587851848 0.481278573296906 no 1601 0.477004765937841 519 690618
SGTC_37 0566-0070 1.56 µM 0.0576589522451196 0.48128453163516 no 1602 0.477010145316182 532 1626686
SGTC_2463 5473429 200 µM 0.0573148453667286 0.481436333959339 no 1603 0.477147197449995 510 5399405
SGTC_1809 st050081 57.6 µM 0.0561437177189814 0.481952995511851 no 1604 0.477613658568364 528 5036894
SGTC_576 1073-0113 22.7 µM 0.0557441400250592 0.482129282533471 no 1605 0.477772817746658 527 5439563
SGTC_641 4092-0595 30 µM 0.0550237211407545 0.482447128149022 no 1606 0.478059782839877 516 786260
SGTC_994 3910-0338 138 µM 0.0547429815469357 0.482570992244348 no 1607 0.478171613179688 524 3479481
SGTC_2024 5144227 134 µM 0.0544912734716729 0.48268204887963 no 1608 0.478271880511121 508 3475211
SGTC_803 4488-1585 147 µM 0.0521575286596268 0.483711788062272 no 1609 0.479201587031143 528 747204
SGTC_1945 st075991 56.6 µM 0.0516578927028389 0.483932261277084 no 1610 0.479400644584951 496 1084980
SGTC_597 k018-0003 82.8 µM 0.0514840280496992 0.484008983290198 no 1611 0.479469914371082 524 6786234
SGTC_1572 epiandrosterone 68.9 µM 0.0510055959824984 0.484220106140897 no 1612 0.479660530702614 512 441302 A steroid.
SGTC_1849 st056239 19.2 µM 0.0502109744794127 0.484570767042943 no 1613 0.479977133108269 525 5393181
SGTC_346 4513-0042 7.16 µM 0.0497111574954942 0.484791338906786 no 1614 0.480176282529138 501 2827372
SGTC_1996 st072960 66.8 µM 0.0496604436598488 0.48481371945037 no 1615 0.480196489464759 514 1719405
SGTC_3279 9140807 49.47 µM 0.0492190571027982 0.485008509945188 no 1616 0.480372362149716 531 45595718
SGTC_633 0437-0093 97.7 µM 0.0482199338319221 0.485449451142725 no 1617 0.480770481882422 533 2831118
SGTC_387 norethindrone acetate 66.7 µM 0.0467714051587143 0.486088759035387 no 1618 0.481347709730381 528 541197
SGTC_1982 st072467 71.9 µM 0.0467309901028042 0.486106596734042 no 1619 0.481363815394457 500 3163533
SGTC_167 3672-0051 66.205 µM 0.0460558092519409 0.486404600468798 no 1620 0.48163288385739 524 3237971
SGTC_2926 9010726 65.15 µM 0.0458030773407901 0.486516150400702 no 1621 0.481733603011821 511 2994293
SGTC_203 k066-0004 30.888 µM 0.0454713085540651 0.486662586954005 no 1622 0.481865821846227 526 6795412
SGTC_2073 5212005 126 µM 0.0452914505490574 0.486741973675147 no 1623 0.481937500960302 534 691789
SGTC_119 0121-0043 24.815 µM 0.0449853275284657 0.486877093153716 no 1624 0.482059502025406 518 1092378
SGTC_958 1222-0007 33 µM 0.043790247832678 0.487404603027002 no 1625 0.482535800365468 524 7312461
SGTC_3126 9127922 49.47 µM 0.043257641112524 0.48763970354301 no 1626 0.482748078544349 537 45595682
SGTC_1573 oleylamine 1.06 µM 0.0431888062512814 0.487670088588201 no 1627 0.482775514040742 527 5356789 An amine of the fatty acid oleic acid.
SGTC_723 4182-0001 115 µM 0.0429563050584757 0.48777271966023 no 1628 0.482868182595267 517 744821 YLR208W SEC13
SGTC_1251 0490-5699 265 µM 0.0426887428474265 0.487890828428254 no 1629 0.482974826648478 524 3883818
SGTC_1106 tegaserod maleate 11.7 µM 0.0426451998198964 0.487910049529302 no 1630 0.482992181998532 524 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2315 7733312 200 µM 0.0412201507608051 0.488539120979553 no 1631 0.483560194669914 516 726316
SGTC_1006 4099-6547 255 µM 0.0409596928604715 0.488654100239887 no 1632 0.483664014657442 518 3146833
SGTC_2243 6634756 200 µM 0.0406552619965913 0.4887884925798 no 1633 0.483785363919517 489 885676
SGTC_2737 bleomycin 30.5 nM 0.0403368761480451 0.488929046770502 no 1634 0.483912277388067 529 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1280 0880-0253 10.1 µM 0.040198980380571 0.488989922479235 no 1635 0.483967245256521 522 6836607
SGTC_1703 st026983 48.3 µM 0.0396688803973992 0.489223943728548 no 1636 0.484178555992383 511 1104023
SGTC_1488 4013-0813 75.9 µM 0.0393697768056701 0.489355989510583 no 1637 0.484297787917678 530 2910057
SGTC_1515 3460-0031 42.1 µM 0.039159078011867 0.4894490077742 no 1638 0.484381779804893 520 2876596
SGTC_2296 7971656 126.45 µM 0.0389355361981442 0.489547696538162 no 1639 0.484470892125308 530 666570
SGTC_807 1315-0151 48 µM 0.0387097408872431 0.489647380820873 no 1640 0.48456090356329 535 4011080
SGTC_516 3992-2719 87.3 µM 0.0371581807589487 0.490332381906126 no 1641 0.485179441243575 511 5350887 YDR037W KRS1
SGTC_342 k048-0088 23.3 µM 0.0370687074498266 0.490371884528016 no 1642 0.485215111354935 537 6820570
SGTC_797 k781-0471 270 µM 0.0370679948050362 0.490372199162312 no 1643 0.485215395463814 515 23738129
SGTC_3318 9139014 38.6185 µM 0.0369794429447806 0.490411295056649 no 1644 0.485250698340762 534 16643984
SGTC_1626 st003712 1.76 µM 0.0368488892820774 0.490468935032335 no 1645 0.485302746242871 530 24207035
SGTC_3203 9113543 49.47 µM 0.0339825363954374 0.491734489585995 no 1646 0.486445538297709 521 17018012
SGTC_1692 fluoroquinolonic acid 71 µM 0.033826808564195 0.491803249168033 no 1647 0.486507629016033 532 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2374 9071832 200 µM 0.0337934666866539 0.49181797086862 no 1648 0.486520922900231 536 17381698
SGTC_206 4546-0025 72.014 µM 0.0331383886672215 0.492107214837562 no 1649 0.486782114910129 540 6620745 YIL048W NEO1
SGTC_326 k292-0812 17.5 µM 0.0329853618351464 0.49217478310017 no 1650 0.486843130426654 532 3579357
SGTC_3299 9121982 43.1275 µM 0.0320572372979875 0.49258459677164 no 1651 0.487213202780251 526 17594604 YPL160W CDC60
SGTC_2063 5246145 200 µM 0.0319383197858186 0.492637105410035 no 1652 0.487260619723389 536 711240
SGTC_105 0111-0055 734.78 µM 0.031860876038294 0.492671301163249 no 1653 0.487291499593188 507 5179370
SGTC_2825 7998094 58.44 µM 0.0312669034923663 0.492933575090845 no 1654 0.487528342341542 540 2987815
SGTC_1139 k015-0024 46.9 µM 0.0312105208779042 0.492958471502631 no 1655 0.487550824777827 532 2766652
SGTC_2705 st078069 42.8 µM 0.0309203952635928 0.493086580338417 no 1656 0.487666512315265 525 1530061
SGTC_2044 5102272 200 µM 0.0306084587462867 0.49322432086452 no 1657 0.487790898103923 531 592666
SGTC_2483 5729050 27.16 µM 0.027760677727499 0.494481839122988 no 1658 0.488926514246782 537 2865180
SGTC_2588 indole-3-carbinol 100 µM 0.0272554299257517 0.494704951666311 no 1659 0.489128002707957 534 3712 Induces cell cycle arrest.
SGTC_205 1486-1330 71.903 µM 0.0268506664674455 0.494883692493609 no 1660 0.489289420884774 541 4118834
SGTC_1453 4237-0541 195 µM 0.0266345138577338 0.494979144458718 no 1661 0.489375622469901 531 739892
SGTC_511 blebbistatin 171 µM 0.0263727831619181 0.495094723874279 no 1662 0.489480001243714 520 3476986 A myosin inhibitor.
SGTC_274 sirtinol 40.1 µM 0.0257781956866676 0.495357293265261 no 1663 0.489717126695302 543 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3076 9116187 49.47 µM 0.0245401794909908 0.495904006627255 no 1664 0.490210867378173 537 27241210
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0240670119374862 0.496112961574421 no 1665 0.490399578178579 536 688803
SGTC_1725 st036284 20.55 µM 0.0203494406983898 0.497754706228285 no 1666 0.491882307982445 516 707914
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.0188894891966867 0.498399458352782 no 1667 0.492464632226202 537 6708784 An antioxidant flavonoid
SGTC_2764 methyldopa 94.69 µM 0.0187119607901199 0.498477859780818 no 1668 0.492535443297657 536 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1560 lithocholic acid 53.1 µM 0.0185013448334885 0.498570873657181 no 1669 0.492619452363985 544 9903 A bile acid which acts as a detergent.
SGTC_1084 voriconazole 435 nM 0.0182695541223521 0.498673238984878 no 1670 0.492711907851212 545 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_805 3852-0218 479 µM 0.018246656607138 0.498683351179457 no 1671 0.492721041115695 537 6615355
SGTC_878 0828-0289 13.7 µM 0.0181185372057101 0.498739932369936 no 1672 0.492772144913499 539 745350 YLR208W SEC13
SGTC_2159 5658611 73.75 µM 0.0178896351229616 0.498841022136119 no 1673 0.49286344883303 533 793844
SGTC_2793 7325131 81.82 µM 0.0176614456567755 0.498941797264338 no 1674 0.492954468877906 536 4176441
SGTC_648 0375-0473 33.3 µM 0.0174201797677105 0.499048347395854 no 1675 0.493050705235494 533 1713139
SGTC_2582 agaric acid 100 µM 0.0172400976004892 0.499127877036166 no 1676 0.493122536838312 533 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_269 exalamide 29 µM 0.0165554648837251 0.499430231492847 no 1677 0.493395626779089 543 3316 A derivative of salicylamide.
SGTC_3025 9087895 49.47 µM 0.0158757277038873 0.499730424256951 no 1678 0.493666767024563 533 17173641
SGTC_2569 tetrandrine 100 µM 0.014654908380598 0.499730424256951 no 1679 0.49415374669539 541 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2699 st077704 54.6 µM 0.0145331045794487 0.499676631950454 no 1680 0.49420233420707 538 645852
SGTC_149 3970-0822 46.1 µM 0.0143868526670859 0.49961204261363 no 1681 0.494260674178949 538 3114250 YBL034C STU1
SGTC_112 phenothiazine 287.218 µM 0.0143558972747909 0.499598371762802 no 1682 0.494273022318506 543 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_318 1488-0629 67.2 µM 0.0142114742560225 0.499534590133876 no 1683 0.494330632889645 536 3662576
SGTC_1474 0330-0125 5.35 µM 0.0140529889938583 0.499464598201275 no 1684 0.494393853047998 543 X1474
SGTC_3287 9117173 37.0625 µM 0.0134435947660981 0.499195471269287 no 1685 0.494636943192131 541 2789709
SGTC_399 oxolinic acid 75 µM 0.0118306706207703 0.498483157249096 no 1686 0.495280355381455 535 4628 A DNA gyrase inhibitor.
SGTC_67 0335-0847 266 µM 0.0115998703197097 0.498381229493567 no 1687 0.495372425061287 541 4552207 YOR254C SEC63
SGTC_1862 st057513 3.81 µM 0.0114023459815647 0.498293997401374 no 1688 0.495451220659518 541 5393163
SGTC_2966 9084041 48.03 µM 0.0108765861034711 0.498061808022346 no 1689 0.495660955488652 533 17741380
SGTC_1992 st073643 23.3 µM 0.00932175872600732 0.497375159533938 no 1690 0.496281210174061 542 3161292
SGTC_1355 1499-0035 1.68 µM 0.00803803561670782 0.496808242864077 no 1691 0.496793322271743 542 1548538
SGTC_794 k038-0031 316 µM 0.00791932068955709 0.496755816390519 no 1692 0.49684068116803 545 6624242
SGTC_1868 st057644 42.7 µM 0.00791066350581766 0.496751993237303 no 1693 0.496844134776471 541 688665
SGTC_1372 2752-0194 270 µM 0.00633518847879249 0.496056243147519 no 1694 0.497472642367262 541 823334
SGTC_2738 aclarubicin 5.55 µM 0.00574732482525676 0.49579663793658 no 1695 0.497707161750752 545 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_496 calpeptin 138 µM 0.00563847148352231 0.495748567637155 no 1696 0.497750587247415 545 73364 A calpain inhibitor.
SGTC_3272 9137413 49.47 µM 0.00560608740774503 0.495734266643718 no 1697 0.497763506420264 538 17614870
SGTC_1212 0520-0165 585 µM 0.00557209723460794 0.49571925639438 no 1698 0.497777066325653 542 5403258
SGTC_1720 st037298 9.481 µM 0.00467445862821564 0.495322856456221 no 1699 0.498135167606493 546 597396
SGTC_697 0508-1955 564 µM 0.00448270583175858 0.495238178423543 no 1700 0.498211665102439 547 6243113
SGTC_2090 5301565 104.445 µM 0.00431725001517671 0.495165113309166 no 1701 0.498277671784195 539 2056344
SGTC_2650 prasterone 100 µM 0.00396735171643164 0.495010599126056 no 1702 0.498417259811117 544 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1312 1218-2183 165 µM 0.00316373717353287 0.494655727895547 no 1703 0.49873785358292 547 6744073
SGTC_2071 5230951 39.92 µM 0.00299296728260565 0.494580317499296 no 1704 0.498805980589752 544 1799272
SGTC_1386 3228-0095 33.8 µM 0.00263868293841281 0.494423869447318 no 1705 0.498947319032868 545 870181
SGTC_2061 5245884 80.95 µM 0.00190620494264685 0.494100418004122 no 1706 0.499239534713808 547 573863
SGTC_2381 9035592 200 µM 0.00151754719222662 0.493928794054676 no 1707 0.499394586494889 545 4749657
SGTC_3137 9097352 49.47 µM 0.00137896715522627 0.493867599988046 no 1708 0.499449871872845 547 44120435
SGTC_548 1436-0017 110 µM 0.00112187430096151 0.4937540735056 no 1709 0.499552437001935 546 9677137
SGTC_94 0334-0113 514.748 µM 0.000673994561070846 0.493556300994418 no 1710 0.499731115093186 547 6795178
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.000451948817005453 0.493458251721763 no 1711 0.499819698514457 547 442882
SGTC_3027 9089541 49.47 µM 0.000259741809898615 0.493373378730782 no 1712 0.499896378011209 547 9943819
SGTC_489 paxilline 115 µM 0.00020762500947177 0.493350365528019 no 1713 0.499917169605848 548 105008 A toxic potassium channel blocker.
SGTC_514 4466-0038 2.65 nM -0.000130980890398295 0.493200847946403 no 1714 0.499947746185045 549 5722064
SGTC_864 0469-0573 172 µM -0.000181097823223414 0.493178717985616 no 1715 0.499927752421822 549 689425
SGTC_3302 9125395 16.351 µM -0.000840348856005093 0.492887616766002 no 1716 0.499664749350511 549 17599668
SGTC_581 0958-0271 211 µM -0.000846050734254979 0.492885099040757 no 1717 0.499662474631008 549 4591145
SGTC_768 0384-0033 77.3 µM -0.00107807383876094 0.492782647002194 no 1718 0.499569910847635 549 3965305 YMR134W ERG29
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.00239878389235812 0.492199484015122 no 1719 0.499043024601558 550 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_231 b-estradiol 524 µM -0.00243620951259087 0.49218295887141 no 1720 0.499028093982907 550 450 A steroid.
SGTC_1409 3909-8004 61.9 µM -0.00244574227194318 0.492178749719041 no 1721 0.499024290973483 549 2119279
SGTC_3170 9103054 49.47 µM -0.00274787736053905 0.492045343613625 no 1722 0.498903756919114 550 16432970
SGTC_182 3448-4371 550.524 µM -0.00354681702343554 0.491692580476451 no 1723 0.498585027695209 548 3491403
SGTC_2338 7999974 200 µM -0.00473182516231314 0.491169365040866 no 1724 0.498112281923676 552 315925
SGTC_409 arachidonic acid 100 µM -0.00473928397625207 0.491166071805525 no 1725 0.498109306320799 551 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_471 1-acyl-paf 4 µM -0.00481022393481392 0.491134750236731 no 1726 0.49808100569457 552 16759367
SGTC_2867 9039098 71.43 µM -0.0060188726276594 0.49060111352718 no 1727 0.497598831726269 555 6463460
SGTC_2834 9001755 58.44 µM -0.00605123077564993 0.490586827141561 no 1728 0.497585922928004 556 2989575
SGTC_230 MPP+ 141.667 µM -0.00655086966459795 0.490366234050795 no 1729 0.497386599809269 555 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1503 4585-0012 61.3 µM -0.00748337756344766 0.489954535041606 no 1730 0.497014592154033 561 2922052
SGTC_682 0kpi-0099 17 µM -0.0081928003033869 0.489641334502529 no 1731 0.496731582127912 555 1714895 YML126C ERG13
SGTC_927 2425-1185 123 µM -0.00823807127101736 0.48962134819773 no 1732 0.496713522234323 557 730375
SGTC_1421 4029-0249 71.4 µM -0.00857125275270558 0.489474255468021 no 1733 0.496580606749394 551 2894095
SGTC_1295 1013-0063 9.78 µM -0.00936985443268467 0.489121695217445 no 1734 0.496262023601099 559 6826038
SGTC_1487 3970-0795 2.82 µM -0.00991527755563721 0.488880911069456 no 1735 0.496044441374874 552 3765103
SGTC_2525 harmine 47.85 µM -0.0114913048019462 0.488185176379359 no 1736 0.495415733549876 554 5280953 A monoamine oxidase inhibitor
SGTC_2076 5212012 200 µM -0.0137189035669912 0.487201868308975 no 1737 0.494527121000472 553 604802
SGTC_69 0096-0274 206.684 µM -0.0147480227695337 0.48674761976431 no 1738 0.494116603442903 555 6741392
SGTC_2294 7971431 200 µM -0.0173464859056722 0.4856007477761 no 1739 0.493080100391207 562 5741572
SGTC_1020 4335-0961 93.3 µM -0.0180554844609863 0.485287840553904 no 1740 0.492797295205091 582 669075
SGTC_1492 4158-0558 28.5 µM -0.0189618816109211 0.484887827267616 no 1741 0.492435757003139 556 3967268
SGTC_870 0573-2213 57.6 µM -0.02016538624148 0.484356717390424 no 1742 0.491955720022768 555 3916321
SGTC_2305 7443522 69.23 µM -0.0206917806910747 0.484124426751882 no 1743 0.491745762838054 559 5415886
SGTC_913 3487-1245 167 µM -0.0213146051314864 0.483849589848287 no 1744 0.491497346637994 557 4016153
SGTC_2057 5236571 38.335 µM -0.0219156052791263 0.483584390734337 no 1745 0.491257638276125 560 54684039 YBR257W POP4
SGTC_12 0849-0099 9.267 µM -0.0221524644402165 0.483479875544426 no 1746 0.491163168077849 553 6071388
SGTC_1050 3232-1156 69.3 µM -0.0222875446945924 0.483420271271177 no 1747 0.491109292154856 553 700529
SGTC_1943 st076331 65.2 µM -0.0234281851928299 0.482916977619698 no 1748 0.490654361320136 558 24208415
SGTC_2677 mitomycin C 100 µM -0.0236303191245247 0.482827791314063 no 1749 0.490573743867652 558 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1558 st069300 45.6 µM -0.0245021215189195 0.482443141232276 no 1750 0.490226045748375 562 24208000
SGTC_1546 5-methoxyflavanone 78.7 µM -0.0248871877373009 0.482273250399489 no 1751 0.490072473387403 557 147795
SGTC_1422 4031-0024 15.5 µM -0.024941089601459 0.482249469206729 no 1752 0.490050976327602 560 782427
SGTC_3323 9138564 53.9225 µM -0.0249469146342104 0.482246899239528 no 1753 0.490048653198595 560 43912313 YNL103W MET4
SGTC_1434 4073-0095 163 µM -0.0250531942435493 0.482200009485136 no 1754 0.490006267016714 559 24133745
SGTC_1259 0671-0132 43 µM -0.0260752649216847 0.481749092349004 no 1755 0.489598653043094 568 X1259
SGTC_2630 antimycin a 100 µM -0.0267455774124841 0.481453376529411 no 1756 0.489331330300884 570 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1843 st055809 45.5 µM -0.0274879764600873 0.481125870839349 no 1757 0.489035264810052 563 16413835
SGTC_2600 tangeritin 87.95 µM -0.0280268520480175 0.480888156489208 no 1758 0.488820367359152 564 68077 A bioactive flavone.
SGTC_2306 7482397 179.52 µM -0.0283386972798299 0.480750595207224 no 1759 0.488696008508729 563 891448
SGTC_3243 9134147 49.47 µM -0.0295349020224439 0.480222946340168 no 1760 0.488218991643388 561 24282180
SGTC_1762 st045503 25.4615 µM -0.0296380186499957 0.480177462950111 no 1761 0.488177872061993 566 4645554
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.03044984666979 0.479819385334854 no 1762 0.487854145686189 556 551469
SGTC_2808 7946468 45.46 µM -0.030552341567401 0.479774178477575 no 1763 0.487813275153717 574 2970879
SGTC_1785 bathophenanthroline 24 µM -0.0321783123659705 0.479057055720057 no 1764 0.487164925723117 561 72812 An iron chelator.
SGTC_2688 kanamycin b 96.69 µM -0.0329518381275629 0.478715921385213 no 1765 0.486856497184674 567 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2829 7992743 58.44 µM -0.0332802930488263 0.478571073443479 no 1766 0.48672553446135 558 16462845
SGTC_1624 st003710 6.25 µM -0.0338419745168984 0.478323379645285 no 1767 0.486501582138398 559 24207033
SGTC_1807 st050092 58.9 µM -0.0341785620505799 0.478174953180336 no 1768 0.486367380778484 573 5008496
SGTC_822 1487-0950 154 µM -0.0345558823806807 0.478008568197098 no 1769 0.486216940615569 560 1958375
SGTC_1045 1348-1485 165 µM -0.0350841830576028 0.477775612642521 no 1770 0.486006306869769 563 6810614
SGTC_2114 5491910 81.25 µM -0.0355373925341056 0.477575774795866 no 1771 0.485825615132283 565 2849228
SGTC_3133 9127736 49.47 µM -0.0356141739842763 0.477541919397979 no 1772 0.48579500314342 578 27243420
SGTC_450 aminopyrene 156 nM -0.0368426554475874 0.477000264825041 no 1773 0.485305231495442 560 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3058 9093861 49.47 µM -0.0375075356979716 0.476707127527317 no 1774 0.485040165879049 565 17217477
SGTC_3212 9128307 49.47 µM -0.0391808534790604 0.475969439001167 no 1775 0.484373099312089 593 27243542
SGTC_502 l-744,832 89.3 µM -0.0393607033070802 0.475890156375372 no 1776 0.48430140491632 573 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_704 1310-0270 142 µM -0.0398190430407559 0.475688112256317 no 1777 0.484118697059803 572 5718033
SGTC_626 0214-0009 33 µM -0.0401286164100806 0.475551650469486 no 1778 0.483995293787262 584 3437874
SGTC_2087 5276107 200 µM -0.0407261384829279 0.475288267300683 no 1779 0.483757111691196 560 144405
SGTC_1135 dihydrocapsaicin 536.708 nM -0.040891857229133 0.475215221650104 no 1780 0.483691054504633 589 107982 A Capsaicinoid.
SGTC_1547 harmine 94.2 µM -0.0421104121842561 0.474678131698417 no 1781 0.483205339906082 561 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1963 st076565 50.3 µM -0.042363203846991 0.474566717044598 no 1782 0.48310458053878 563 4914280
SGTC_1297 1068-0111 14.1 µM -0.0432455276794176 0.474177859877218 no 1783 0.482752906586954 564 767057
SGTC_2791 5663188 71.43 µM -0.0437521490278377 0.473954593150677 no 1784 0.482550985036291 569 54690634
SGTC_1216 1165-0504 9.65 µM -0.0440388135775367 0.473828264439673 no 1785 0.482436732552155 575 6304004
SGTC_2250 alverine citrate 130 µM -0.0444286348295794 0.473656480362723 no 1786 0.482281368442717 570 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1136 pergolide 1.05886 µM -0.0452508446248013 0.473294170012714 no 1787 0.481953683788656 563 47811 A dopamine receptor agonist.
SGTC_383 2324-0395 7.37 µM -0.0468142032331529 0.472605330373583 no 1788 0.481330654451028 580 3146421
SGTC_783 0848-0141 92.7 µM -0.0481772133635492 0.472004834103482 no 1789 0.480787505098667 567 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1521 st012942 49.4 µM -0.0483656820404968 0.471921806140865 no 1790 0.480712404523154 563 24207259
SGTC_49 0717-0965 32.132 µM -0.0499264027487393 0.471234293700133 no 1791 0.480090518592415 611 5889349 YGL099W LSG1
SGTC_1447 4239-0816 81.9 µM -0.0504848731780595 0.470988302837402 no 1792 0.479868001744147 566 1341554
SGTC_87 0100-0052 35.5 µM -0.0519106643662851 0.470360331459604 no 1793 0.479299938399378 565 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_444 curcumin 90.4 µM -0.0523464734589501 0.470168399589094 no 1794 0.479126311793239 576 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3196 9111891 49.47 µM -0.0527255258041772 0.470001469225241 no 1795 0.478975300329188 571 18891510
SGTC_707 0865-0008 204 µM -0.0538380373315368 0.469511562289046 no 1796 0.478532102021556 570 723043
SGTC_2947 9072639 7.68 µM -0.054146119844165 0.46937590282575 no 1797 0.478409373897445 587 16488146
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.0552499310361178 0.468889885600152 no 1798 0.477969675219432 570 91467 include heat shock
SGTC_1111 tnp00062 510.699 nM -0.0554077063245323 0.4688204196014 no 1799 0.477906828255823 571 676306
SGTC_2714 st079313 56.9 µM -0.0554604131577819 0.468797213816169 no 1800 0.477885833554047 571 2939799
SGTC_124 0136-0217 7.121 µM -0.056501881999985 0.468338697348643 no 1801 0.47747099815146 579 3976905
SGTC_308 4092-1169 104 µM -0.0567402339312527 0.468233766549369 no 1802 0.47737606179106 576 2268590 YDL196W YDL196W
SGTC_2846 9008642 19.48 µM -0.0573048846170039 0.467985196524297 no 1803 0.477151164693804 587 2992898
SGTC_2726 cimetidine 79.27 µM -0.0584859214508058 0.467465322004888 no 1804 0.476680788176617 573 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_886 0866-0150 153 µM -0.0588333655276455 0.467312392910318 no 1805 0.476542416315485 585 271463
SGTC_1770 st043884 66.3 µM -0.0593492237434869 0.467085344470898 no 1806 0.476336977651474 570 670149
SGTC_1484 3473-2379 286 µM -0.0594534065948235 0.467039491010043 no 1807 0.476295487970317 574 671917
SGTC_1607 st000305 50.6 µM -0.0604952999922347 0.466580952005104 no 1808 0.475880579529425 582 5457690
SGTC_1257 0669-0121 16 µM -0.0610059477653749 0.466356231235235 no 1809 0.475677236124437 576 4307855
SGTC_1907 st060210 83.7 µM -0.0611385952977838 0.466297858786534 no 1810 0.475624416012133 592 688793
SGTC_1276 0871-0068 94.2 µM -0.0611801463240249 0.466279574123925 no 1811 0.475607870523867 581 3414906
SGTC_2069 5228469 200 µM -0.0612582199277355 0.466245217776285 no 1812 0.475576781973643 568 2835210
SGTC_2967 9089538 49.85 µM -0.0615255676913122 0.466127573100174 no 1813 0.475470326450194 577 728216
SGTC_1067 clotrimazole 1.36 µM -0.0621554808444052 0.465850395560205 no 1814 0.475219507520601 572 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2317 5986382 200 µM -0.0636265202465412 0.465203166178637 no 1815 0.474633807209529 570 877883
SGTC_1401 3807-4679 7.6 µM -0.0640337077530194 0.465024027606065 no 1816 0.474471693483507 568 3291456
SGTC_753 1322-0200 289 µM -0.0648805466822266 0.464651490987515 no 1817 0.474134554726741 584 5403907
SGTC_142 0335-0849 62.6745 µM -0.0652094744120342 0.464506799287395 no 1818 0.474003608848321 571 3889043 YPR107C YTH1
SGTC_2773 thioridazine 9.09 µM -0.0660626464095861 0.464131520207162 no 1819 0.473663974852147 575 5452 An antipsychotic.
SGTC_2434 5670830 169.91 µM -0.0676217564605491 0.463445807532174 no 1820 0.473043367944018 596 1549830
SGTC_2721 ifenprodil 61.44 µM -0.0692078962963528 0.462748318316262 no 1821 0.472412068922523 587 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1051 3253-3903 78 µM -0.0692708590630321 0.462720633414895 no 1822 0.472387010550918 569 5509239
SGTC_103 0844-0104 51.839 µM -0.069457568605818 0.462638537778561 no 1823 0.472312703196435 580 5375804
SGTC_3232 9132874 49.47 µM -0.0696116219485279 0.462570802175352 no 1824 0.472251393202705 587 3784940
SGTC_2646 retinol 96.75 µM -0.0697738733215682 0.462499463159666 no 1825 0.472186821276064 587 445354 A vitamin A analog and teratogen.
SGTC_1333 1482-0047 286 µM -0.0710432439663074 0.461941385489536 no 1826 0.471681669354544 586 3811116
SGTC_1697 st025554 27.742 µM -0.0717388939660716 0.461635575299004 no 1827 0.471404851489136 578 1269519
SGTC_2183 6420625 130.508 µM -0.072751974503185 0.461190262141766 no 1828 0.471001744210131 581 2897619
SGTC_2682 pyrogallin 40.03 µM -0.0731960098088034 0.460995095763603 no 1829 0.470825070791946 590 822798 An ATP competetive kinase inhibitor.
SGTC_3326 9140064 16.379 µM -0.0737306294604167 0.460760127410311 no 1830 0.470612363163201 584 1868434
SGTC_710 3448-4187 58 µM -0.073860428371121 0.460703082120431 no 1831 0.470560721695458 579 3946412
SGTC_85 0868-0259 160.055 µM -0.0747995079615861 0.460290390435603 no 1832 0.470187116656191 582 83173
SGTC_198 3454-2873 16.191 µM -0.0756823104170981 0.459902469522213 no 1833 0.469835924933378 589 710957
SGTC_1557 sumaresinolic acid 42.3 µM -0.0766731044579253 0.459467140436135 no 1834 0.469441800536468 581 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_286 k060-0067 22.9 µM -0.0767759940814853 0.459421936192582 no 1835 0.469400874152664 592 5985051
SGTC_2870 9038528 12.99 µM -0.077397836265847 0.459148742905107 no 1836 0.469153531015415 621 6463316
SGTC_523 1934-0222 13.7 µM -0.0782955839623961 0.458754370393642 no 1837 0.468796465084352 596 1361595
SGTC_1002 4049-0206 172 µM -0.0804042979773821 0.45782819156965 no 1838 0.467957854341416 579 4662749
SGTC_1385 3091-4834 14.1 µM -0.081799671080634 0.457215448336828 no 1839 0.467403008819409 583 4072814
SGTC_860 0443-0016 25.1 µM -0.0819370805931146 0.457155113859545 no 1840 0.4673483737562 581 5337942
SGTC_2204 7233102 200 µM -0.0823516650690324 0.456973081960351 no 1841 0.46718353555954 598 2172480
SGTC_3129 9127257 49.47 µM -0.0827556001760606 0.456795734569553 no 1842 0.467022936949319 639 837894
SGTC_449 xestospongin c 11.1929 µM -0.0828321725896583 0.45676211648077 no 1843 0.466992493497355 597 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_767 0929-0023 86 µM -0.0852262969969449 0.45571116565574 no 1844 0.466040742327372 589 1204563
SGTC_227 fluconazole 33.516 µM -0.0855035126564102 0.455589495936624 no 1845 0.465930551502164 598 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1485 3909-9022 254 µM -0.08744645293858 0.454736858616361 no 1846 0.465158323332126 585 714516
SGTC_2563 tomatine 8.54 µM -0.0882302624363535 0.454392951502966 no 1847 0.464846832577957 590 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2106 5357045 167.29 µM -0.0895292574864474 0.453823075097104 no 1848 0.464330651413749 592 668842
SGTC_1837 st055472 66.5 µM -0.0906572425175122 0.453328298813853 no 1849 0.463882473098201 601 676091
SGTC_2353 9059630 146.67 µM -0.0915746890682703 0.452925925940649 no 1850 0.463517981064669 608 4779114
SGTC_1678 st019265 80.2 µM -0.092002567046592 0.45273828410761 no 1851 0.463348000017997 612 5367020
SGTC_2912 7964298 10.93 µM -0.0927381205470802 0.452415738778515 no 1852 0.4630558058378 589 2975850
SGTC_700 3453-2283 142 µM -0.0931464888516532 0.452236679976731 no 1853 0.462893592592539 588 565664
SGTC_2831 7999036 19.48 µM -0.093188739094754 0.452218154906044 no 1854 0.462876810179885 604 2988270
SGTC_1870 st057514 26.5 µM -0.0932892918309937 0.452174066902522 no 1855 0.462836869432602 576 5393161
SGTC_2505 galangin 7.89 µM -0.0940159188834916 0.451855490090593 no 1856 0.46254825565332 614 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2260 7964312 200 µM -0.0944615169789043 0.451660140787815 no 1857 0.462371275357201 615 231951
SGTC_2506 ethyl hematommate 54.16 µM -0.0947847301948043 0.451518452089687 no 1858 0.462242907899901 597 3940691 An allergen.
SGTC_3015 9080845 49.47 µM -0.0955153416498983 0.451198192843123 no 1859 0.461952752548699 606 5296973
SGTC_2907 7721985 69.9 µM -0.0979143328672961 0.450146833596409 no 1860 0.461000159347485 599 3267881
SGTC_2626 ethyl orsellinate 100 µM -0.098387448640493 0.449939531403875 no 1861 0.460812320428612 585 75653 A natural product.
SGTC_2864 9034755 47.6 µM -0.0984371038500494 0.449917775080949 no 1862 0.46079260656176 584 4930451
SGTC_952 1185-0122 232 µM -0.0987121387808195 0.449797271847176 no 1863 0.460683415293811 578 678600
SGTC_2242 6630449 61.2675 µM -0.0990049546336915 0.449668983205027 no 1864 0.460567168102888 619 691249 YDR170C SEC7
SGTC_777 1315-0167 517 µM -0.0996624569239752 0.449380937127804 no 1865 0.460306153565709 584 4221767
SGTC_2853 9015042 58.44 µM -0.103548748689353 0.447678936015935 no 1866 0.458763730770182 577 6457456
SGTC_1658 st012944 20 µM -0.104040994627122 0.447463425009883 no 1867 0.458568408036652 620 24207260
SGTC_363 0455-0021 3.06 µM -0.104353583194844 0.44732657814104 no 1868 0.458444378371637 615 4597466
SGTC_1821 st053465 65.6 µM -0.105126391539892 0.446988280488795 no 1869 0.45813775895571 613 675086
SGTC_348 k064-0012 10.7 µM -0.105692098077272 0.446740666303445 no 1870 0.457913325027441 601 5066323
SGTC_589 1227-0070 34.1 µM -0.105802956797947 0.44669214500254 no 1871 0.457869345387403 594 2841384
SGTC_2917 7979103 53.79 µM -0.106369261260368 0.446444293980404 no 1872 0.457644690323768 618 2980565
SGTC_1957 st077035 62.4 µM -0.107048707307584 0.446146952586869 no 1873 0.457375169441158 593 705593
SGTC_3258 9138477 49.47 µM -0.107074223755779 0.446135786584561 no 1874 0.457365048024302 580 4970355
SGTC_2807 7945238 51.95 µM -0.107193041671246 0.446083792406128 no 1875 0.457317917783147 615 17148797
SGTC_321 4534-3890 65.3 µM -0.107346701137161 0.446016553098822 no 1876 0.457256968204254 605 699746
SGTC_3350 9150499 3.57 µM -0.107923698761544 0.445764080605203 no 1877 0.457028109011814 596 4910996 YPR165W RHO1
SGTC_3173 9105693 49.47 µM -0.1086219370177 0.445458587180648 no 1878 0.456751180240212 615 17096658
SGTC_3252 9135871 49.47 µM -0.108878431680072 0.445346373677293 no 1879 0.456649456977271 620 17682838
SGTC_3310 9130229 44.1445 µM -0.10953063772463 0.445061060678754 no 1880 0.45639081127887 621 7761258
SGTC_2844 9010103 25.97 µM -0.109698375154214 0.444987687129424 no 1881 0.456324294539672 632 2480525
SGTC_852 0418-0143 439 µM -0.111276666763266 0.444297386112784 no 1882 0.455698478852023 594 5369229
SGTC_537 1334-0398 209 µM -0.111981250950707 0.443989274929776 no 1883 0.455419136315598 620 5846986
SGTC_903 1134-0042 114 µM -0.112271982009745 0.443862149529479 no 1884 0.45530387822056 601 701009
SGTC_3259 9138485 49.47 µM -0.112841730127338 0.443613037570056 no 1885 0.455078016875238 595 17646153
SGTC_2960 9079389 5.97 µM -0.113330002634338 0.443399567058991 no 1886 0.454884465899868 615 16457355
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.113788859042481 0.443198972101525 no 1887 0.454702585212025 591 6708561
SGTC_590 k048-0076 22.4 µM -0.114921190170434 0.442704021430253 no 1888 0.454253794521889 612 6832814
SGTC_1717 st033143 58.0435 µM -0.11546935194073 0.442464447761271 no 1889 0.454036555783899 610 674616
SGTC_782 0083-0095 30.5 µM -0.116217925925116 0.44213731809196 no 1890 0.45373991509286 640 3591729 An indicator and reagent.
SGTC_3016 9080866 49.47 µM -0.117393438540548 0.441623694331653 no 1891 0.453274141703837 611 17066299
SGTC_412 gemfibrozil 100 µM -0.117572849986523 0.441545311626669 no 1892 0.453203059140177 584 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_661 1304-0007 33.6 µM -0.118649846318206 0.441074833093473 no 1893 0.452776386296735 603 3117130
SGTC_3195 9113082 49.47 µM -0.119134448687856 0.440863164923484 no 1894 0.452584419488355 583 17018038
SGTC_965 1291-5240 308 µM -0.119574979469565 0.440670761321553 no 1895 0.452409920489066 612 2834598
SGTC_1274 0865-0114 173 µM -0.119745752819895 0.440596179134072 no 1896 0.452342277791487 590 870624
SGTC_3233 9132340 49.47 µM -0.119832318998731 0.440558373717992 no 1897 0.452307989773799 642 17682950
SGTC_2696 st077691 74.316 µM -0.120738201481372 0.44016278683205 no 1898 0.45194919995693 618 757133
SGTC_3053 9095903 49.47 µM -0.121967687650571 0.43962598210769 no 1899 0.451462304346101 616 17174018
SGTC_617 3770-0098 35 µM -0.122362705016639 0.439453537481228 no 1900 0.451305886798077 611 5962639
SGTC_2792 7535235 81.82 µM -0.122760452061492 0.439279912822669 no 1901 0.451148396000643 596 1281891
SGTC_2085 5307070 144.047 µM -0.12341983228343 0.438992105720053 no 1902 0.450887326621215 622 2840351
SGTC_1392 3455-1037 33.9 µM -0.123726433883875 0.438858290846131 no 1903 0.450765940628618 599 981132
SGTC_328 k915-0120 63.5 µM -0.12468214010398 0.438441222121636 no 1904 0.450387598593404 602 6624543
SGTC_2100 5377183 190 µM -0.125069982991388 0.438271987554399 no 1905 0.450234073385639 602 2844202
SGTC_1043 0916-0009 19.3 µM -0.125195636770796 0.438217161166364 no 1906 0.450184335710427 588 3101130
SGTC_3099 9120367 49.47 µM -0.125261279423182 0.438188519844912 no 1907 0.450158352617441 591 24824940
SGTC_940 3232-1287 54.8 µM -0.127049361475239 0.437408465656172 no 1908 0.449450665127153 610 1585493 YIL048W NEO1
SGTC_2675 theaflavin digallate 100 µM -0.127124062934743 0.437375882274703 no 1909 0.449421103250493 603 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_35 0133-0054 64.071 µM -0.127227516703473 0.437330758374375 no 1910 0.449380163582952 614 99677
SGTC_1241 0364-0022 50.8 µM -0.127291580480309 0.437302815794421 no 1911 0.449354811951868 625 4563895
SGTC_2179 6298986 200 µM -0.127299613929309 0.43729931188178 no 1912 0.449351632930727 603 738374
SGTC_2368 9071271 200 µM -0.1277017494969 0.437123920543932 no 1913 0.449192502766089 632 27209959
SGTC_673 1082-0474 110 µM -0.127748940254785 0.437103339114893 no 1914 0.449173829317549 607 3098046
SGTC_2862 9027634 71.43 µM -0.128036011617161 0.436978141597765 no 1915 0.449060237206946 598 5012562
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.129208539349765 0.436466844654733 no 1916 0.448596319714614 604 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1180 1193-0155 285 µM -0.129341176927808 0.436409012869616 no 1917 0.448543845289868 620 2921347
SGTC_209 4077-0173 175.592 µM -0.129655421881906 0.436272003229866 no 1918 0.44841952647566 594 15993494
SGTC_3 0833-0587 95.581 µM -0.129903164954761 0.436163993554122 no 1919 0.448321520118615 598 5382644
SGTC_2009 4012297 12.05 µM -0.130184453537032 0.436041364660971 no 1920 0.448210247090612 633 45595307
SGTC_2464 5717415 7.67 µM -0.130379444006502 0.435956361385997 no 1921 0.448133114534091 601 5285744
SGTC_2895 9054447 58.44 µM -0.130676688057779 0.435826787834232 no 1922 0.448015537209589 595 2697450
SGTC_2430 5571206 200 µM -0.131314237414051 0.435548892873427 no 1923 0.447763364744132 602 1731771
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.132707073767984 0.434941894367371 no 1924 0.447212524146822 618 75037 A free radical scavenger.
SGTC_1914 st062367 72.6 µM -0.132883305134493 0.434865103579824 no 1925 0.447142835187769 626 978205
SGTC_2450 5739737 12.93 µM -0.133069151191758 0.434784125963192 no 1926 0.4470693459619 592 2262825
SGTC_1247 0448-0043 5.84 µM -0.133209604639558 0.43472292881782 no 1927 0.447013807570391 625 3089013 YGL099W LSG1
SGTC_1523 st012844 44.7 µM -0.133714947536597 0.434502758185653 no 1928 0.446813992444268 630 4274103
SGTC_2734 clemastine 41.6 µM -0.133724166779801 0.434498741682443 no 1929 0.446810347234334 616 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_324 1315-0088 19.6 µM -0.135069967729968 0.433912495813551 no 1930 0.446278277413113 632 6787421
SGTC_1196 1588-0294 184 µM -0.135478526513912 0.433734551760335 no 1931 0.446116770539166 620 6144269
SGTC_2121 5257820 149.641 µM -0.136768814066579 0.433172667126631 no 1932 0.445606767363006 591 791256
SGTC_3208 9114115 49.47 µM -0.137505677037909 0.432851844147817 no 1933 0.44531555287152 619 650895
SGTC_1003 4049-0218 100 µM -0.137723459271278 0.432757032342645 no 1934 0.445229489128966 598 295161
SGTC_2988 9073640 71.4286 µM -0.138180125262825 0.432558234728976 no 1935 0.445049031075216 626 9102229
SGTC_1622 st003707 19.4 µM -0.138558227966801 0.432393650506663 no 1936 0.44489962703597 639 10140899
SGTC_2893 9048488 25.97 µM -0.139168930904188 0.432127842578627 no 1937 0.444658329549781 591 6467338
SGTC_726 3448-4391 34.2 µM -0.140404616583443 0.431590105535849 no 1938 0.444170155240011 633 1356692
SGTC_2657 nystatin 74.44 µM -0.141124746083832 0.431276783014065 no 1939 0.443885697370834 615 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_724 3910-0327 137 µM -0.141250515168012 0.431222066332489 no 1940 0.443836020370654 619 2885483
SGTC_1570 verbenone 133 µM -0.141468193400545 0.43112736708076 no 1941 0.443750042649511 619 29025 A natural terpanoid with antifungal properties.
SGTC_526 4469-0568 170 µM -0.141707419846483 0.431023298010194 no 1942 0.443655556950779 610 2901964
SGTC_3193 9111931 49.47 µM -0.142436664989065 0.430706088984007 no 1943 0.443367551570827 621 17087244
SGTC_669 0108-0021 26.2 µM -0.142450029070655 0.430700276256115 no 1944 0.443362273888528 694 17201
SGTC_2679 rapamycin 1 nM -0.144728484418383 0.429709479092628 no 1945 0.442462624309462 629 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1432 4049-0298 68.4 µM -0.149024468044566 0.427842558803737 no 1946 0.440767162918987 617 741646
SGTC_2687 chenodiol 100 µM -0.150158279927947 0.427350101830298 no 1947 0.440319870211143 610 5702181 A cholesterol synthesis inhibitor.
SGTC_25 0118-0223 35.662 µM -0.150335094755754 0.427273314709068 no 1948 0.440250122999297 614 5333628
SGTC_2273 7815444 169.05 µM -0.15097780840358 0.426994220337704 no 1949 0.439996610772434 658 2824616
SGTC_10 0279-0212 42.575 µM -0.153303004681344 0.425984824659426 no 1950 0.439079665646061 621 39851 YBR002C RER2
SGTC_977 1348-1378 135 µM -0.154156304414071 0.425614518218904 no 1951 0.438743247150937 606 X977
SGTC_2913 7966556 36.57 µM -0.15465609698067 0.425397653707626 no 1952 0.438546221492768 624 2976516
SGTC_374 0880-0231 82.3 µM -0.155115108667955 0.425198504268271 no 1953 0.438365285677702 626 6833587
SGTC_218 alverine citrate 93.75 µM -0.155402786036387 0.425073700643568 no 1954 0.438251893954981 618 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_742 0kpi-0133 140 µM -0.157364436251978 0.424222874969917 no 1955 0.437478819983388 640 2728852
SGTC_1652 st011932 78 µM -0.157958697511982 0.423965195789768 no 1956 0.437244672328083 618 1551076
SGTC_2993 9054257 71.4286 µM -0.157977352536626 0.423957107261346 no 1957 0.437237322330047 629 6470217 YGL055W OLE1
SGTC_2391 6285546 200 µM -0.158279211305066 0.423826230451429 no 1958 0.437118394309573 603 846083
SGTC_2314 7727897 200 µM -0.158528329716398 0.423718226588663 no 1959 0.437020249511656 611 900724
SGTC_3229 9132204 49.47 µM -0.159112506400039 0.423464982615058 no 1960 0.436790117532241 607 17682924
SGTC_1288 0973-0013 65.5 µM -0.159214925782964 0.423420586473815 no 1961 0.436749772393781 618 4315430
SGTC_3228 9131799 49.47 µM -0.16012132564983 0.423027728120667 no 1962 0.436392751237583 618 17015818
SGTC_214 4373-3496 70 µM -0.160628880318856 0.422807773522973 no 1963 0.436192853525359 631 3779166
SGTC_1608 st001473 40.5 µM -0.160798124689653 0.422734434893212 no 1964 0.43612620114887 653 7292267
SGTC_1078 idebenone 36.1 µM -0.161265014462883 0.422532131531452 no 1965 0.43594233848757 612 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1779 st039427 55 µM -0.16417164723913 0.421273148987085 no 1966 0.434798010234692 620 1124498
SGTC_3089 9117425 49.47 µM -0.165352208874795 0.420762028053771 no 1967 0.434333383793484 639 9401657
SGTC_595 3909-8003 73.7 µM -0.165452359450046 0.420718674269055 no 1968 0.434293972306779 638 699517
SGTC_2854 9024559 71.43 µM -0.165889837693542 0.420529307330629 no 1969 0.434121822515388 648 3163529
SGTC_823 0417-1665 178 µM -0.166258913101756 0.420369563560244 no 1970 0.433976599282797 647 3429856
SGTC_2112 5488546 200 µM -0.166798224750173 0.420136161476073 no 1971 0.433764407781672 645 600757
SGTC_984 1492-0255 2.91 µM -0.166883065806185 0.420099446708716 no 1972 0.433731028909078 634 1585198
SGTC_358 0075-0058 9.45 µM -0.166931498283082 0.420078487980029 no 1973 0.43371197441382 710 1069125
SGTC_2316 5844804 197.44 µM -0.167074843046123 0.420016458122005 no 1974 0.433655580057094 649 776813
SGTC_2991 9074669 71.4286 µM -0.1690584721742 0.419158283069692 no 1975 0.432875324544933 635 17333109
SGTC_3056 9094900 49.47 µM -0.169766272762924 0.418852161017604 no 1976 0.432596976143884 631 25236784
SGTC_1860 st056228 74.6 µM -0.171189748883721 0.418236659951865 no 1977 0.43203728385962 652 688679
SGTC_2224 6650123 117.647 µM -0.172114969708702 0.417836708211658 no 1978 0.431673572129127 625 2908370
SGTC_2011 4012611 177 µM -0.172352609998422 0.417733995463043 no 1979 0.431580163160173 644 2049887
SGTC_1309 pyrazolanthrone 13.4 µM -0.172622212276886 0.417617474917273 no 1980 0.431474195565087 635 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_845 0330-0138 4.51 µM -0.172675948523477 0.417594251286395 no 1981 0.431453075038934 621 9039800
SGTC_464 bw-b 70c 158 µM -0.172677103032213 0.417593752336115 no 1982 0.431452621272288 655 5353454
SGTC_1733 st037357 54.9 µM -0.172746869948332 0.417563601037218 no 1983 0.431425200340167 666 1272339 YGL099W LSG1
SGTC_735 3076-0345 636 µM -0.173611954101146 0.417189776315079 no 1984 0.431085218341584 610 2888990
SGTC_50 0929-0078 56.389 µM -0.174109365730364 0.416974866049575 no 1985 0.430889756416594 629 1377751
SGTC_2390 9097792 176.6 µM -0.176168941696053 0.416085276166601 no 1986 0.43008061004269 619 4497149
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.179682427054623 0.414568695354564 no 1987 0.428700945039222 610 688664
SGTC_2017 5132927 60.65 µM -0.180149552731479 0.414367157926549 no 1988 0.428517580733962 641 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1214 0358-0031 63.7 µM -0.181057366620919 0.413975553814334 no 1989 0.428161273983382 691 4301366
SGTC_1269 0831-0796 3.05 µM -0.181202128288475 0.413913115800578 no 1990 0.428104462061765 620 927758
SGTC_292 k038-0015 474 µM -0.181856766785024 0.413630786980287 no 1991 0.427847566879916 643 46368540
SGTC_2490 carminic acid 95.39 µM -0.181934242066182 0.413597376827051 no 1992 0.427817165821869 637 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1283 0922-0125 16.4 µM -0.182079391044954 0.413534785003071 no 1993 0.427760210970081 617 3360884
SGTC_314 1671-0008 2.74 µM -0.183449320879825 0.412944145866196 no 1994 0.427222739979038 649 3913060
SGTC_701 4424-0219 185 µM -0.183908566702557 0.412746188105457 no 1995 0.427042592091803 651 2911779
SGTC_1776 st049249 45.9 µM -0.183932570278001 0.41273584198191 no 1996 0.427033176651989 619 1822314
SGTC_1966 st070145 16.1 µM -0.18397602723301 0.412717111133899 no 1997 0.427016130699535 623 3748532
SGTC_1182 1222-0449 220 µM -0.186260936606267 0.411732548789947 no 1998 0.426120069717031 619 658318
SGTC_3005 9076496 71.4286 µM -0.186992498496441 0.411417437501572 no 1999 0.425833257271136 636 21368410
SGTC_2706 st078239 82.5 µM -0.187382985788623 0.411249263276256 no 2000 0.425680180853009 612 15434492
SGTC_1430 4049-0248 69.1 µM -0.187723149497478 0.411102775592787 no 2001 0.425546841102792 630 22774488
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.18781957284179 0.411061254215583 no 2002 0.425509045953922 677 61125 An anti-inflammatory.
SGTC_428 3448-4153 16.5 µM -0.188095778275411 0.410942321418128 no 2003 0.425400785240268 622 3834874
SGTC_1348 1493-0373 93.8 µM -0.188376372039616 0.410821507408022 no 2004 0.425290810247884 662 3010129
SGTC_2868 9035608 32.47 µM -0.188534414949341 0.410753463298266 no 2005 0.425228869990816 614 6462614
SGTC_583 1488-1091 88.9 µM -0.188716870086553 0.410674912039522 no 2006 0.425157364376519 658 4303273
SGTC_1634 st006576 41 µM -0.189117686490081 0.410502363666665 no 2007 0.425000289899745 622 3915356
SGTC_247 mechlorethamine 29.705 µM -0.190401609018598 0.409949761679958 no 2008 0.424497218461173 625 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1715 st032160 10.2275 µM -0.191201022066991 0.409605783475741 no 2009 0.42418405144726 647 5289825
SGTC_2077 5212015 200 µM -0.191401462706334 0.409519547081316 no 2010 0.424105537088493 625 780900
SGTC_316 k060-0003 58.6 µM -0.19257614594166 0.409014246451831 no 2011 0.423645464000316 648 6152314
SGTC_1818 st052136 56.3 µM -0.196346779416145 0.40739329969409 no 2012 0.422169374613862 628 674169
SGTC_2168 5727979 200 µM -0.196445731929511 0.407350782499199 no 2013 0.422130652308736 624 695210
SGTC_1244 0416-0015 52.5 µM -0.196676862973876 0.407251476049437 no 2014 0.422040208556599 640 96201
SGTC_2768 sulfasalazine 50.2 µM -0.197988782563206 0.40668791727105 no 2015 0.421526920112987 693 5384001 An antioxidant and salicylic acid derivative.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.198351754326265 0.406532030258078 no 2016 0.421384930944363 621 16725076
SGTC_551 k048-0028 34.9 µM -0.198589352568169 0.406429995959183 no 2017 0.42129199157183 657 6836383
SGTC_2146 5545642 200 µM -0.199098196630939 0.406211499110678 no 2018 0.421092965935399 632 825326
SGTC_1332 1480-0653 17.5 µM -0.200501853971189 0.405608922428227 no 2019 0.420544054088629 641 5749438
SGTC_2556 citropten 84.59 µM -0.200526329494827 0.405598417299307 no 2020 0.420534484099215 623 2775 A potential DNA crosslinker.
SGTC_418 lividomycin a 100 µM -0.201853854422097 0.405028732949438 no 2021 0.420015489124582 632 72394 An antibiotic.
SGTC_709 3807-1509 243 µM -0.202900318400828 0.404579802787041 no 2022 0.419606472704936 655 1886677 YPL242C IQG1
SGTC_3289 9119912 71.43 µM -0.205566681413071 0.403436509366358 no 2023 0.418564703008925 695 17014829
SGTC_545 4218-0007 221 µM -0.205734051579834 0.40336477115027 no 2024 0.418499329091946 659 2840508
SGTC_2872 9044037 25.97 µM -0.206023991520024 0.403240504763674 no 2025 0.418386085387106 621 6465195
SGTC_2816 7982706 58.44 µM -0.206786268349405 0.402913844476442 no 2026 0.418088390323042 648 2981853
SGTC_1046 2001-0062 216 µM -0.206815414854034 0.402901355599488 no 2027 0.418077008550585 636 739778
SGTC_2906 7926292 26.41 µM -0.207654817432105 0.402541725680041 no 2028 0.417749249523703 680 2966319
SGTC_3347 9188721 44.724 µM -0.208710547388183 0.402089530523456 no 2029 0.417337102921811 665 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_166 k072-0058 166.424 µM -0.209680777936593 0.401674072384012 no 2030 0.416958414508425 631 5846229
SGTC_1298 1079-1278 263 µM -0.210133710777266 0.401480162023796 no 2031 0.416781657705516 673 2840950
SGTC_351 caspofungin 25 nM -0.213198780782473 0.400168578994265 no 2032 0.415585959601333 629 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_906 1165-0455 526 µM -0.213223644498389 0.400157944070235 no 2033 0.41557626332911 661 3252859
SGTC_2437 5741531 144.16 µM -0.214026210516791 0.399814703386439 no 2034 0.415263308847469 641 2262990
SGTC_2724 maprotiline 69.64 µM -0.216193313095784 0.398888266346158 no 2035 0.414418532839711 621 4011 A tricyclic antidepressant.
SGTC_2067 5224629 34.075 µM -0.217099347590427 0.398501104786643 no 2036 0.414065461194652 653 2835000
SGTC_790 1575-0012 79.1 µM -0.217165784048777 0.398472719459049 no 2037 0.414039574369228 669 378741 YLR208W SEC13
SGTC_2311 7694451 200 µM -0.217283173438402 0.398422565535693 no 2038 0.413993834755002 637 2163142
SGTC_451 chloral hydrate 100 µM -0.217455559041346 0.398348917846232 no 2039 0.413926668525096 675 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3336 9143619 71.43 µM -0.218433082932113 0.397931362333355 no 2040 0.413545845678439 652 45595730
SGTC_3040 9091894 49.47 µM -0.21912345944506 0.397636534033963 no 2041 0.41327693840773 632 25236966
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.219956313129519 0.397280938052135 no 2042 0.412952589265108 669 5024745
SGTC_628 1636-0253 16 µM -0.220844857990385 0.396901658232401 no 2043 0.41260661708645 666 4456143
SGTC_174 3553-0389 74.3 µM -0.221092648743793 0.396795904880825 no 2044 0.412510147043621 635 738071
SGTC_937 3122-0005 46.7 µM -0.221582168396562 0.396587007600128 no 2045 0.412319582501131 629 759535
SGTC_1351 1496-0003 46.5 µM -0.222019696189196 0.396400322405966 no 2046 0.412149275301621 632 3891978
SGTC_2215 7188065 200 µM -0.223601053936536 0.39572578400046 no 2047 0.411533871754426 652 940217
SGTC_539 4859-0462 2.54 µM -0.224097283338522 0.395514178388297 no 2048 0.411340803156445 637 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_851 0394-0702 453 µM -0.225310538854639 0.394996943310827 no 2049 0.410868850810001 637 762646
SGTC_2360 9040895 200 µM -0.225829876273385 0.394775595874013 no 2050 0.410666869675145 657 4914414
SGTC_989 1501-0895 10.3 µM -0.225978658275832 0.394712189569948 no 2051 0.410609009619532 650 2830112
SGTC_1015 4130-4525 82 µM -0.226469384633563 0.394503076897805 no 2052 0.410418184107766 646 1363237
SGTC_1569 carminic acid 40.6 µM -0.226486084347935 0.394495961201744 no 2053 0.410411690573195 622 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3017 9080681 49.47 µM -0.226948225084816 0.394299058454427 no 2054 0.410232001031355 659 16451914
SGTC_841 0251-0215 91.2 µM -0.227838401874208 0.393919859984335 no 2055 0.409885935671427 670 3888614
SGTC_738 1315-0003 72.4 µM -0.228254600841044 0.393742601573653 no 2056 0.409724158114197 698 6251474
SGTC_2431 5490079 200 µM -0.228975141357305 0.393435776698156 no 2057 0.409444118600365 685 5722345
SGTC_2458 5808907 16.39 µM -0.229438974356236 0.393238299547218 no 2058 0.409263873410129 667 2731747
SGTC_2915 7971052 15.16 µM -0.229834286598233 0.393070016822993 no 2059 0.409110270478247 637 5741558
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.230998945629712 0.392574342730993 no 2060 0.408657810573416 650 4620898
SGTC_2643 anethole 100 µM -0.231342290671217 0.392428249704615 no 2061 0.408524447214062 679 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_689 0833-0039 98 µM -0.231548405060286 0.392340555485248 no 2062 0.40844439258283 688 5374726
SGTC_115 0527-0192 112.043 µM -0.232216041500173 0.392056537876866 no 2063 0.408185109476283 667 4233931
SGTC_172 1112-0046 2.638 µM -0.234473741178975 0.391096522147451 no 2064 0.407308608270978 677 2802135 YIL048W NEO1
SGTC_2186 6124449 200 µM -0.234571773817352 0.391054851834994 no 2065 0.407270559778181 650 3834182 YLR033W RSC58
SGTC_1760 st045453 10.4495 µM -0.235374682307364 0.390713610082522 no 2066 0.406958967360629 653 3323419 YIL048W NEO1
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.235569805140281 0.390630694206468 no 2067 0.406883253052832 666 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_479 n-linoleoylglycine 10 µM -0.236528322585778 0.390223452224628 no 2068 0.406511366213175 669 6433346 An anti-infammatory.
SGTC_693 4161-2696 114 µM -0.236591464973656 0.39019662936066 no 2069 0.406486871103901 649 805759
SGTC_696 1560-0013 611 µM -0.236778441464237 0.390117204880009 no 2070 0.406414338623141 660 1650269
SGTC_3158 9100007 49.47 µM -0.237720253572881 0.389717208678388 no 2071 0.406049036918535 660 19297233
SGTC_708 3448-5400 146 µM -0.238276318518906 0.389481097620048 no 2072 0.405833393768269 644 3462195
SGTC_1030 k029-0042 36.7 µM -0.239419376205322 0.388995871430207 no 2073 0.405390203401223 652 6080581
SGTC_395 anisomycin 6.25 µM -0.239477101322427 0.388971371793713 no 2074 0.40536782522695 680 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_811 0416-0114 265 µM -0.239499205993422 0.38896199026824 no 2075 0.405359256037722 658 6612453
SGTC_1014 4130-3005 69.3 µM -0.239741478199038 0.388859170866722 no 2076 0.405265338755271 670 743608
SGTC_1133 3473-0247 50 µM -0.241548924856239 0.388092343510805 no 2077 0.404564851113419 660 711311
SGTC_391 gliotoxin 8.33 µM -0.242107913217248 0.38785527525217 no 2078 0.404348273361496 665 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_282 k297-0036 65.7 µM -0.243007689389532 0.38747376590672 no 2079 0.403999720351907 670 5061378
SGTC_579 4491-1009 110 µM -0.243286816150771 0.387355436902587 no 2080 0.403891608409892 654 1271041
SGTC_1863 st057641 20.1 µM -0.24364414707781 0.387203970418235 no 2081 0.403753216988053 651 3921635
SGTC_2795 7780010 54.55 µM -0.244082920823915 0.387018005202605 no 2082 0.403583299892795 648 953673
SGTC_165 k038-0023 64.381 µM -0.24425876857556 0.386943483031202 no 2083 0.403515207170599 657 46368543
SGTC_2581 avocatin a 64 µM -0.246069955775826 0.386176166573886 no 2084 0.40281403996914 703 6710728 A skin care supplement.
SGTC_2125 5246583 200 µM -0.246479343344962 0.386002789499687 no 2085 0.402655596452505 672 835267
SGTC_2636 apigenin dimethyl ether 100 µM -0.246950171170517 0.385803420409613 no 2086 0.402473393744279 699 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2963 9082507 9 µM -0.248150474843784 0.385295295918066 no 2087 0.402008991680375 689 16459611
SGTC_2103 5378138 10 µM -0.248195790571893 0.385276116264111 no 2088 0.401991461557893 663 244142
SGTC_1175 0741-0056 27.6 µM -0.248595995608815 0.385106743682687 no 2089 0.401836653160136 653 765927
SGTC_2958 9077254 16.72 µM -0.249055245095598 0.384912409640042 no 2090 0.401659024006496 659 16457351
SGTC_2268 7933382 153.85 µM -0.249279528122845 0.384817513499217 no 2091 0.401572282887375 639 935025 YOR257W CDC31
SGTC_610 4215-0184 155 µM -0.249452079485541 0.384744510180888 no 2092 0.401505552211158 665 5605015
SGTC_2890 9046729 58.44 µM -0.24946874571855 0.384737459219593 no 2093 0.40149910704179 667 903329
SGTC_2481 5478948 45.16 µM -0.249812647408832 0.384591973696275 no 2094 0.401366119286839 652 77792
SGTC_3263 9137018 49.47 µM -0.249985775071798 0.384518739237912 no 2095 0.401299174653056 645 43844957
SGTC_476 mead acid 10 µM -0.25007015370014 0.384483047861665 no 2096 0.401266548355853 658 5312531 An omega 9 fatty acid.
SGTC_2760 etidronate 98.04 µM -0.250203865338747 0.384426491085665 no 2097 0.401214848099767 635 3305 A chelator and antioxidant.
SGTC_48 0382-0018 55 µM -0.251151348665671 0.384025799193156 no 2098 0.400848548660015 654 762596
SGTC_1425 4048-4433 7.33 µM -0.25133746378422 0.383947105425136 no 2099 0.400776606318292 674 23734946
SGTC_3078 9116413 49.47 µM -0.252750749008188 0.383349692152336 no 2100 0.400230414356457 644 17177322
SGTC_3066 9117245 49.47 µM -0.255360407592836 0.382247286562517 no 2101 0.399222373717549 679 17176980
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.256259424468403 0.381867732712434 no 2102 0.398875262970588 665 1377
SGTC_715 0868-0130 184 µM -0.256766441725912 0.38165372631559 no 2103 0.398679538666769 657 2876258
SGTC_584 0986-0246 15.4 µM -0.25684153506933 0.381622033316538 no 2104 0.398650552484558 683 53315 YDR232W HEM1
SGTC_3213 9129884 49.47 µM -0.257391333686603 0.381390016071161 no 2105 0.39843834614834 675 17190742
SGTC_896 0964-0007 44.5 µM -0.260254757206144 0.380182330495573 no 2106 0.397333634435711 654 6756758
SGTC_3184 9108758 49.47 µM -0.261210214804807 0.379779613135285 no 2107 0.396965200615423 660 902885
SGTC_1884 5633444 25 µM -0.261773857719849 0.379542103477352 no 2108 0.396747897476216 656 5724239
SGTC_1775 st081588 35.1725 µM -0.262334963635894 0.379305708006446 no 2109 0.39653160427855 682 1426443 YGL099W LSG1
SGTC_3341 9147222 25.867 µM -0.262731508423157 0.379138669799138 no 2110 0.396378764740229 686 1939759
SGTC_1789 tunicamycin 25 nM -0.265541703984143 0.377955567698476 no 2111 0.395296093711182 684 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_393 acivicin 6.25 µM -0.269250232116533 0.376396016461733 no 2112 0.393868563678559 682 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2608 thymoquinone 42.66 µM -0.270749047979443 0.37576628833291 no 2113 0.393292025173934 648 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3171 9103192 49.47 µM -0.271736138300965 0.375351742442867 no 2114 0.392912456058188 666 13018434
SGTC_3047 9092122 49.47 µM -0.271965474414167 0.375255449303467 no 2115 0.392824283242353 693 17173831
SGTC_3125 9127534 49.47 µM -0.272120405320371 0.375190401656513 no 2116 0.392764720095799 640 1639235
SGTC_3248 9135562 49.47 µM -0.273065617771757 0.374793631722324 no 2117 0.392401387856345 664 17650701
SGTC_1356 1502-0781 85.8 µM -0.273140481830547 0.374762211843891 no 2118 0.392372614703829 667 567702
SGTC_1471 k673-0312 37 µM -0.274030910872132 0.374388569319989 no 2119 0.392030433550346 663 24099884
SGTC_2217 6934799 96.0675 µM -0.275050200279763 0.373960999094864 no 2120 0.391638835405704 676 675606
SGTC_2930 9013230 14.89 µM -0.275141320516083 0.373922783635371 no 2121 0.39160383349889 661 2995857
SGTC_2629 bisabolol 100 µM -0.276036016876291 0.373547617466896 no 2122 0.391260201512679 688 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1748 st037455 53.6035 µM -0.276293066747688 0.373439852854275 no 2123 0.391161490338325 685 580690
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.277408467383727 0.372972351271623 no 2124 0.390733240320209 688 688667
SGTC_3330 9141424 71.43 µM -0.279377088593483 0.372147693149756 no 2125 0.389977726003447 657 27261020
SGTC_2326 6164455 177.58 µM -0.279521927545626 0.372087043013592 no 2126 0.389922156313793 675 2888790
SGTC_226 1,3-diallylurea 8.28947 mM -0.279697390112148 0.372013573738137 no 2127 0.389854840417521 669 74537 YKL182W FAS1
SGTC_1397 3532-0190 20.1 µM -0.280205335571089 0.371800914281265 no 2128 0.389659986691983 654 5322280
SGTC_758 0868-0029 16 µM -0.283021400760829 0.370622634824348 no 2129 0.388580215989798 646 762687
SGTC_2271 7849410 118.62 µM -0.283699614603716 0.370339041805414 no 2130 0.388320295051524 710 972430
SGTC_3156 9099931 49.47 µM -0.285548701876987 0.369566210015646 no 2131 0.387611899015177 651 18111053
SGTC_3221 9128209 49.47 µM -0.286320252602542 0.369243893530036 no 2132 0.387316423906032 671 16460723
SGTC_678 1218-2179 85.9 µM -0.286519106481934 0.36916083690637 no 2133 0.387240280869622 671 6820081 YOR116C RPO31
SGTC_3141 9094609 49.47 µM -0.28682915892783 0.369031347424509 no 2134 0.387121567503748 687 25236309 YDL196W YDL196W
SGTC_2929 9013348 24.6 µM -0.289321801217901 0.367990868093013 no 2135 0.386167565210012 677 2995952
SGTC_2540 epiandrosterone 100 µM -0.289404465588221 0.367956378850074 no 2136 0.386135939049773 663 441302 A steroid.
SGTC_470 aa-861 153 µM -0.289852618611375 0.367769418902488 no 2137 0.385964495534291 663 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1153 4055-0057 267 µM -0.291533342056932 0.367068536059831 no 2138 0.385321723737917 660 882706
SGTC_2804 7954240 19.48 µM -0.291805043802616 0.366955274525959 no 2139 0.385217844303066 669 828705
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.293708700543452 0.366162041860243 no 2140 0.384490252666839 684 390807
SGTC_1591 genipin 88.4 µM -0.294259336445368 0.365932704415733 no 2141 0.384279871293045 673 442424 A DNA cross-linking agent.
SGTC_608 k048-0125 159 µM -0.294400341412967 0.365873984163245 no 2142 0.384226003026378 700 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2838 9002687 71.43 µM -0.294470842389585 0.365844625842781 no 2143 0.384199070307298 699 6457060
SGTC_1233 0325-0408 14.2 µM -0.295150386404082 0.36556168750007 no 2144 0.383939500205904 694 12874
SGTC_1524 corynanthine 62.1 µM -0.295403395027078 0.365456362240219 no 2145 0.38384287005493 706 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_501 nsc-95397 161 µM -0.295824762232724 0.365280973306564 no 2146 0.383681955695532 698 262093
SGTC_3222 9128301 49.47 µM -0.296079235725453 0.365175065476958 no 2147 0.383584785469525 683 4911358
SGTC_666 0272-0154 136 µM -0.296777868296054 0.364884358573899 no 2148 0.38331805158906 671 6870312
SGTC_546 peri-Naphthalide 147 µM -0.297620113842215 0.364533996352651 no 2149 0.382996560632641 661 223824 A penicillin ester.
SGTC_2904 7225135 42.03 µM -0.298003571067233 0.36437452103755 no 2150 0.382850219036183 694 4446116
SGTC_1545 lovastatin 49.4 µM -0.299377469001009 0.363803326077023 no 2151 0.382326025705584 656 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2075 5212009 200 µM -0.300238441475843 0.363445532828369 no 2152 0.381997642390777 693 780898
SGTC_2514 salinomycin 42.74 µM -0.300829227922307 0.363200089322506 no 2153 0.381772359755639 701 23682228 A polyether potassium ionophore.
SGTC_2826 7992541 19.48 µM -0.301843204720749 0.362778961438665 no 2154 0.381385796710471 718 2985066
SGTC_2080 5212524 12.4 µM -0.302018469311637 0.362706186827053 no 2155 0.381318991763753 680 260183
SGTC_667 1498-1044 59 µM -0.302115962180525 0.362665707290093 no 2156 0.38128183230306 686 6739982
SGTC_1452 4194-0072 190 µM -0.30262700800013 0.362453543576299 no 2157 0.381087064820076 699 1343545
SGTC_3239 9133757 49.47 µM -0.302795684762725 0.362383525681928 no 2158 0.381022786100434 692 17036923
SGTC_284 0988-0104 32.6 µM -0.303635037118648 0.362035178158207 no 2159 0.38070297764104 683 4666532
SGTC_1819 st053448 58.6 µM -0.303636313548584 0.362034648501935 no 2160 0.380702491360109 674 2857616
SGTC_1146 3579-1023 7 µM -0.303918308073159 0.361917640983665 no 2161 0.380595064656207 673 X1146
SGTC_962 1254-0300 21.5 µM -0.304263871212499 0.361774274644036 no 2162 0.380463433842115 672 7340576
SGTC_3345 9148410 3.559 µM -0.305225270120284 0.361375514069719 no 2163 0.380097293677113 681 4903596
SGTC_2576 guaiol 23.12 µM -0.305706781367639 0.361175853628472 no 2164 0.379913954786496 673 227829
SGTC_528 3492-0019 172 µM -0.306554750485758 0.360824332016709 no 2165 0.379591150041902 655 2869262
SGTC_82 0054-0107 293.755 µM -0.308056866583837 0.360201925534989 no 2166 0.379019530818317 691 3104697
SGTC_39 0986-0283 58.349 µM -0.308108929594246 0.360180359696004 no 2167 0.378999723357923 662 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2911 7942208 15.64 µM -0.308415371257667 0.360053432690176 no 2168 0.378883143549139 680 1243384
SGTC_1654 st012436 41.8 µM -0.308535484280535 0.360003686527299 no 2169 0.378837451875819 707 4323132
SGTC_133 0724-0033 378.92 µM -0.309157351346111 0.359746171200311 no 2170 0.37860091721696 673 280309
SGTC_2021 4019055 173 µM -0.311848981014678 0.358632302018555 no 2171 0.377577648711872 711 44827708 YER133W GLC7
SGTC_1018 4259-0013 28.1 µM -0.312028879922631 0.358557897712549 no 2172 0.377509287636574 696 6801262
SGTC_1959 st077091 55.8 µM -0.313356403865978 0.358009013841581 no 2173 0.377004951065083 685 821356 YKL052C ASK1
SGTC_960 1222-0186 7.7 µM -0.313530721569155 0.357936961447276 no 2174 0.376938741989509 705 3126296
SGTC_1791 st048313 56.1 µM -0.313680226008386 0.357875169386608 no 2175 0.37688196033125 668 1204976
SGTC_1038 k292-0204 154 µM -0.313789240034778 0.357830114869188 no 2176 0.376840558575828 677 4454212
SGTC_2810 7959871 45.46 µM -0.314240168810581 0.357643771104342 no 2177 0.376669318205509 686 2974535
SGTC_404 fumagillin 50 µM -0.316101611887203 0.35687489982296 no 2178 0.375962691657826 688 12015870 A methionine aminopeptidase binder.
SGTC_2285 7945142 200 µM -0.316282543780181 0.356800196622652 no 2179 0.375894029828627 723 2970608
SGTC_2708 st078559 56 µM -0.316623976833728 0.356659240628481 no 2180 0.375764470131995 685 17250902
SGTC_438 sphingosine 6.67 µM -0.316829421702485 0.356574434938266 no 2181 0.375686519065001 675 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_3286 9117135 37.221 µM -0.317154003000577 0.356440465313085 no 2182 0.375563374914043 670 3438150
SGTC_1630 st005209 31.3 µM -0.318300721689688 0.355967303717538 no 2183 0.375128418465308 677 3367314
SGTC_2892 9047358 58.44 µM -0.319152272563999 0.35561607835206 no 2184 0.374805523400179 714 6466771
SGTC_3298 9116858 71.43 µM -0.320062475163626 0.355240797368789 no 2185 0.374460485519259 722 2506942
SGTC_2487 5918373 44.05 µM -0.321120789640428 0.354804625609765 no 2186 0.37405942804962 687 2876279
SGTC_2521 angolensin 13.4 µM -0.32179849533769 0.354525417132016 no 2187 0.373802677133324 678 821428 A flavenoid.
SGTC_1597 7-benzyloxygramine 47.5 µM -0.322008965513757 0.354438721263893 no 2188 0.373722951239752 692 260807
SGTC_2801 7907800 81.82 µM -0.32214595585035 0.354382296911186 no 2189 0.373671062339036 721 6620925
SGTC_3321 9137793 26.8275 µM -0.322551398077657 0.354215319810422 no 2190 0.373517503237908 671 4904192
SGTC_2190 6049624 200 µM -0.323212529665993 0.353943099865191 no 2191 0.373267146221729 694 2265554
SGTC_1062 mesoridazine 14.2 µM -0.325200141061727 0.353125153856045 no 2192 0.372514800963426 689 4078 A neuroleptic.
SGTC_2504 purpurogallin 52.29 µM -0.325240264363658 0.353108649201006 no 2193 0.3724996185972 669 5281571 An antioxidant.
SGTC_632 0781-2353 4.65 µM -0.325791140199159 0.352882075274219 no 2194 0.372291191222222 691 6811515 YHR007C ERG11
SGTC_1674 st016616 23.6 µM -0.326029964349348 0.352783863670946 no 2195 0.372200842205998 667 625830
SGTC_1258 0671-0043 57.1 µM -0.326505079227307 0.352588511457929 no 2196 0.372021123509065 721 4298767
SGTC_3159 9100096 49.47 µM -0.326706536347131 0.352505690393173 no 2197 0.371944928013903 658 25236875
SGTC_1923 st058458 19.1 µM -0.326848771664983 0.352447220222428 no 2198 0.371891134521411 725 3534982
SGTC_2341 7987486 176.74 µM -0.328162211427812 0.351907455612372 no 2199 0.371394509018319 701 1258686
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.332163502959727 0.350264947515084 no 2200 0.369882900529495 701 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1429 4049-0205 9.46 µM -0.334094808824009 0.349473155807031 no 2201 0.369154008598589 684 22774478
SGTC_2471 5466956 24.79 µM -0.335486361097616 0.348903056314837 no 2202 0.36862911573422 698 724419
SGTC_2478 5763493 32.33 µM -0.335810734156282 0.348770214162867 no 2203 0.368506797544961 673 1365576 YLR208W SEC13
SGTC_2908 7930301 100 µM -0.335924447531773 0.348723648932245 no 2204 0.368463920397992 707 2223178
SGTC_3238 9133470 49.47 µM -0.337507968801221 0.348075439594842 no 2205 0.367867002983553 695 3534688
SGTC_201 4262-0159 12.803 µM -0.339047887423891 0.34744550428547 no 2206 0.367286827710644 709 1341029
SGTC_691 1548-0686 185 µM -0.339283162275321 0.347349297320694 no 2207 0.36719821287849 680 46495133
SGTC_837 0091-0265 12.5 µM -0.339777551802008 0.34714716702581 no 2208 0.367012027143973 695 759367
SGTC_258 haloperidol 50.781 µM -0.341125888164945 0.346596123172699 no 2209 0.366504406451282 692 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1730 st033808 45.1 µM -0.343269383089637 0.345720778724553 no 2210 0.365697905880634 695 1045166
SGTC_128 0906-2981 13.371 µM -0.344843965651438 0.345078287195734 no 2211 0.365105839147077 726 6740226
SGTC_246 cycloheximide 667 µM -0.34662623485935 0.344351589912712 no 2212 0.364436066958332 688 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2549 cedrol 20.94 µM -0.346694970168178 0.344323575460352 no 2213 0.364410244677848 686 6708665 A sedative which affects the nervous system.
SGTC_58 0957-0393 9 µM -0.348746603255192 0.343487785110222 no 2214 0.363639776908802 706 6997992
SGTC_2429 5902844 64.44 µM -0.349910724409189 0.343013887425427 no 2215 0.363202849151384 713 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2134 5324836 1.464 µM -0.350604771505089 0.342731467812366 no 2216 0.362942438184776 695 699272
SGTC_2415 st077333 57.7 µM -0.351566523741517 0.342340259682833 no 2217 0.362581687269779 676 2766255
SGTC_2624 nerol 100 µM -0.352624263286048 0.341910202449557 no 2218 0.362185072582725 719 637566 A natural product oil.
SGTC_1378 2093-0007 380 nM -0.353554804373873 0.341532031256378 no 2219 0.361836275071212 721 3618014
SGTC_761 k216-0224 480 µM -0.353910647301938 0.341387458973185 no 2220 0.361702923709558 753 1340404
SGTC_1035 k081-0041 55.2 µM -0.354015154158569 0.341345004224828 no 2221 0.361663763182299 724 731709
SGTC_3036 9090181 49.47 µM -0.354020343255024 0.341342896264414 no 2222 0.361661818775832 683 25236586
SGTC_1149 3909-7961 23.3 µM -0.355653137701975 0.340679854274553 no 2223 0.36105017195606 685 735261
SGTC_2616 abietic acid 100 µM -0.355868611070718 0.340592391970863 no 2224 0.360969481856298 714 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2858 9025781 8.96 µM -0.356156969352806 0.340475358528782 no 2225 0.360861507619298 700 4894980 YPL153C RAD53
SGTC_1314 1222-0010 41.1 µM -0.356452623679292 0.340355379852846 no 2226 0.360750812929908 708 3526027
SGTC_2053 5265679 138 µM -0.3580948799973 0.339689234725549 no 2227 0.360136155258595 683 764595
SGTC_2344 7990960 76.95 µM -0.358622318793026 0.339475396853042 no 2228 0.359938823997417 714 140813
SGTC_1290 0986-0249 10.2 µM -0.359317957795524 0.339193445117728 no 2229 0.359678620886899 717 53329
SGTC_1027 k015-0025 8.67 µM -0.361043196831144 0.338494571569326 no 2230 0.359033577729039 689 3598955
SGTC_385 1494-0393 12.4 µM -0.361922139600945 0.338138736018224 no 2231 0.358705107447603 713 3090647
SGTC_2756 carbadox 75.1 µM -0.362190221838788 0.338030233027559 no 2232 0.358604943039574 692 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1202 1988-0068 29.6 µM -0.364107979590586 0.337254436988736 no 2233 0.357888689188988 696 2850480
SGTC_156 3474-0145 5.642 µM -0.364362320135454 0.337151599743477 no 2234 0.357793734298759 706 2265471
SGTC_863 0466-0191 129 µM -0.364434330192164 0.337122486202728 no 2235 0.357766851834636 720 765160 YPR165W RHO1
SGTC_1184 1269-1718 139 µM -0.364679986260277 0.337023175222446 no 2236 0.35767514994696 679 5403821
SGTC_2266 7929956 200 µM -0.364875456940941 0.336944160721906 no 2237 0.357602187822063 709 2967153
SGTC_2635 hydroquinidine 100 µM -0.36613093205998 0.336436835586402 no 2238 0.357133688582696 695 442912 An experimental heart treatment.
SGTC_892 0929-0076 29 µM -0.367006597580481 0.336083163898249 no 2239 0.356807048368888 678 5751038
SGTC_2553 4-methylesculetin 85.09 µM -0.368057490678135 0.33565891123371 no 2240 0.356415183453781 709 5319502
SGTC_329 k048-0121 21.3 µM -0.368533121869377 0.335466964498806 no 2241 0.356237876312906 703 6832902
SGTC_1699 st031318 29.054 µM -0.368635287777918 0.335425739807663 no 2242 0.356199794669921 715 5340658
SGTC_2038 4100038 30.985 µM -0.369472577383277 0.335087962027303 no 2243 0.35588775477323 697 3596803
SGTC_3052 9092717 49.47 µM -0.369922389770728 0.334906554603003 no 2244 0.355720159175046 726 25237534
SGTC_1859 st055998 20 µM -0.370733917159062 0.334579366502276 no 2245 0.355417862739942 729 676301
SGTC_1797 st048695 56.8 µM -0.371846793013197 0.334130886252537 no 2246 0.355003460970091 748 592262 YIL048W NEO1
SGTC_1375 2910-0797 186 µM -0.372239030832451 0.333972873872528 no 2247 0.354857444148023 724 742508
SGTC_2 0422-0095 29 µM -0.373099201415099 0.333626458591977 no 2248 0.354537306508544 682 6790840
SGTC_3045 9092950 49.47 µM -0.373157941010863 0.333602807646594 no 2249 0.354515448594707 720 44120432
SGTC_3010 9080089 71.4286 µM -0.374326031753151 0.333132624333716 no 2250 0.354080883507089 718 17027233
SGTC_1768 st044301 37.178 µM -0.374479654409476 0.333070807182305 no 2251 0.354023745356301 750 3931349
SGTC_2036 5160441 105 µM -0.374675113943915 0.332992161592724 no 2252 0.353951051219643 696 134534 YIL048W NEO1
SGTC_867 0518-0118 155 µM -0.374891391057374 0.33290514835025 no 2253 0.353870620938207 727 6848158
SGTC_1915 st067105 30.6 µM -0.375303626871116 0.332739321350663 no 2254 0.353717334557804 724 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2468 5987765 72.9 µM -0.375306537884613 0.332738150475456 no 2255 0.353716252206492 675 26772094
SGTC_75 0159-0059 199.013 µM -0.375616708725098 0.332613402125487 no 2256 0.353600933576564 757 5377270
SGTC_2575 plumbagin 510 nM -0.376323586314812 0.332329170608236 no 2257 0.353338173283467 735 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1307 1187-1599 12.2 µM -0.376465681233268 0.332272046669917 no 2258 0.353285362242397 700 1538471
SGTC_1806 st050005 60.3 µM -0.376644398225146 0.332200205731379 no 2259 0.353218944241315 702 5194765
SGTC_1878 temozolomide 1 mM -0.37749929879902 0.33185663678272 no 2260 0.352901292691878 714 5394 DNA alkylating agent.
SGTC_3116 9124943 49.47 µM -0.378415840201885 0.331488452511945 no 2261 0.352560851392332 684 41905195 YPL160W CDC60
SGTC_1414 3917-0015 5.4 µM -0.378948625269009 0.331274501964693 no 2262 0.352363007275551 732 6618702
SGTC_677 0929-0063 136 µM -0.378970494024828 0.331265721302437 no 2263 0.352354887396685 706 1539583
SGTC_2265 7929201 200 µM -0.3795701692846 0.331024978066495 no 2264 0.352132253937865 741 1265108
SGTC_332 4112-0506 40.9 µM -0.379849301999059 0.330912942377259 no 2265 0.352028641324801 706 2790355
SGTC_1349 flufenamic acid 69 µM -0.380132982595276 0.330799096814876 no 2266 0.351923351816926 707 3371 A non-steroidal anti-inflammatory.
SGTC_2394 5221648 200 µM -0.380207118494703 0.330769347470819 no 2267 0.351895837768651 723 788586
SGTC_3037 9091026 49.47 µM -0.380739098087377 0.330555905414233 no 2268 0.351698426997104 724 25236398 YIL048W NEO1
SGTC_1814 st052110 31.539 µM -0.381185793691683 0.330376723744824 no 2269 0.351532694892833 740 674163
SGTC_1167 k781-0610 148 µM -0.381491403993137 0.33025415759849 no 2270 0.351419324228526 713 4525169
SGTC_126 0417-1624 672.48 µM -0.381828235603469 0.330119091127212 no 2271 0.351294386869162 729 41912 YDL195W SEC31
SGTC_16 erodoxin 22.806 µM -0.382093698190847 0.330012658594926 no 2272 0.351195932981688 728 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3001 9076041 71.4286 µM -0.382414151039621 0.329884197017088 no 2273 0.351077097791173 704 16004211
SGTC_1001 4048-4355 44.4 µM -0.382998042212689 0.329650181150995 no 2274 0.350860607848012 731 21824233
SGTC_2111 5486399 200 µM -0.383905018281123 0.329286809385777 no 2275 0.350524423399283 700 689674
SGTC_2195 6536160 144.242 µM -0.385014587332318 0.328842489806637 no 2276 0.350113303980128 697 3834386
SGTC_488 nitrendipine 139 µM -0.386845378144128 0.328109890564633 no 2277 0.349435340337376 712 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1873 rapamycin 2 nM -0.387534083115962 0.327834473017352 no 2278 0.349180428821615 712 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_582 0987-0078 156 µM -0.388080278312932 0.327616112600539 no 2279 0.348978313048595 730 1625765
SGTC_2732 terfenadine 20 µM -0.388655796962673 0.327386092896404 no 2280 0.3487653926836 724 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1339 1486-1321 22.7 µM -0.388700667976179 0.327368161881856 no 2281 0.348748794087992 717 3469382
SGTC_1177 0983-0204 23.6 µM -0.392991953582853 0.325655156499293 no 2282 0.347162712188904 709 766818
SGTC_3063 1327-0034 4 µM -0.393850197025977 0.325313000744091 no 2283 0.346845820778236 725 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_13 0199-0087 65 µM -0.394824740037021 0.324924658337738 no 2284 0.346486117642491 718 4589825
SGTC_1929 genistein trimethyl ether 50.5 µM -0.397575650388362 0.323829484300964 no 2285 0.345471506125464 688 136420
SGTC_22 0964-0034 14.468 µM -0.398924653730828 0.323292984211778 no 2286 0.344974361418242 737 138402
SGTC_2269 7935389 174.42 µM -0.401428182810538 0.32229830184071 no 2287 0.344052451688353 683 97605
SGTC_3181 9108277 49.47 µM -0.401892163008518 0.32211409630178 no 2288 0.343881695304212 743 17097298
SGTC_3340 9146634 11.102 µM -0.402034419349503 0.322057627627425 no 2289 0.34382934776809 732 4907387
SGTC_2824 7998404 51.95 µM -0.403739217084874 0.321381227829899 no 2290 0.34320224889307 734 837851
SGTC_2359 9039622 200 µM -0.40519768867626 0.320803030679725 no 2291 0.342666101913483 723 6463596
SGTC_210 3551-0445 56.827 µM -0.405315429108175 0.320756372540315 no 2292 0.34262283330049 750 2865180 YOR207C RET1
SGTC_2409 alverine citrate 63.97 µM -0.40550269934552 0.320682166985843 no 2293 0.342554017326088 684 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_728 3030-5151 22.5 µM -0.407183852292767 0.320016333793493 no 2294 0.34193648028349 709 3125388
SGTC_369 0957-0393 4.5 µM -0.408106928721532 0.319650988695039 no 2295 0.341597586718401 761 6997992
SGTC_1090 efavirenz 20.7 µM -0.408207497112213 0.319611195219695 no 2296 0.341560672259606 708 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2157 5649910 96.377 µM -0.410101541523517 0.318862137200059 no 2297 0.340865730978837 737 2858091
SGTC_1352 1496-0991 99 µM -0.41012812502093 0.318851629193917 no 2298 0.340855981098578 753 3000039
SGTC_1387 3342-1166 1.8 µM -0.410355118512826 0.31876190844354 no 2299 0.340772732298281 713 3418228
SGTC_1076 itraconazole 331 nM -0.410515885331308 0.318698370669885 no 2300 0.340713776510815 702 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_970 1315-0089 19.5 µM -0.410700759588788 0.31862531181583 no 2301 0.340645984946094 709 6811083 YLR033W RSC58
SGTC_413 propylparaben 100 µM -0.410961691229286 0.318522208502452 no 2302 0.340550312649405 733 7175 A pharmaceutical preservative.
SGTC_2072 5231554 129 µM -0.411627490562259 0.318259191338301 no 2303 0.340306239455703 736 789545
SGTC_2603 homopterocarpin 100 µM -0.412463177334302 0.317929191539297 no 2304 0.339999982451548 719 101795 A weak amylase inhibitor.
SGTC_1336 1486-0901 104 µM -0.412698490676803 0.317836296001743 no 2305 0.339913765398359 700 5006114
SGTC_644 1498-1197 63.3 µM -0.414367418057276 0.31717777648716 no 2306 0.339302523350952 726 6741615
SGTC_2727 riluzole 51.77 µM -0.41729473248392 0.316024125020604 no 2307 0.338231420462304 729 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_552 k242-0005 476 µM -0.417640612196773 0.315887932179295 no 2308 0.33810494947938 761 4088318
SGTC_2513 baicalein 25.65 µM -0.417675030951998 0.315874380892067 no 2309 0.338092365254139 739 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2117 5521686 200 µM -0.417925645884022 0.315775716716585 no 2310 0.338000740586846 719 803312
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.418304737384068 0.315626497760069 no 2311 0.337862163201855 716 4330530
SGTC_1311 1190-0148 100 µM -0.418777507398198 0.315440446941677 no 2312 0.337689372306557 727 1961333
SGTC_894 0960-0238 55.9 µM -0.419225426445946 0.315264218965354 no 2313 0.337525695651789 739 6741907 YDL195W SEC31
SGTC_1897 st060201 15 µM -0.421187044456791 0.314492941100647 no 2314 0.336809251984558 720 611878
SGTC_2507 purpurin 79.67 µM -0.421509696758116 0.31436615658762 no 2315 0.336691465973157 703 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_373 0844-0104 25.9 µM -0.423866092588641 0.313440887932446 no 2316 0.335831736916817 728 5375804
SGTC_1132 3456-3614 2.5 µM -0.424706213532794 0.313111287106218 no 2317 0.335525426832762 744 3125502
SGTC_1539 benzyladenosine 56 µM -0.424973182046174 0.313006579806573 no 2318 0.335428112352005 702 92208 A nucleotide analog.
SGTC_3051 9093778 49.47 µM -0.426432382758842 0.31243453564478 no 2319 0.334896404561539 747 17217378
SGTC_2671 danthron 100 µM -0.427319660329675 0.312086920780086 no 2320 0.334573257429515 728 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.428198156520347 0.311742911025232 no 2321 0.334253429167636 774 6728940
SGTC_110 0850-0284 111.64 µM -0.428541959281833 0.311608326214097 no 2322 0.334128295921997 720 3906265
SGTC_802 4112-3352 742 µM -0.428714282359958 0.311540878197126 no 2323 0.334065582749772 703 704594
SGTC_980 1473-0395 201 µM -0.429150105393855 0.311370323353055 no 2324 0.333906995276606 739 768876
SGTC_118 0083-0097 135.343 µM -0.430594864486351 0.310805221466107 no 2325 0.333381487973379 743 5207356
SGTC_2116 5511452 16.8835 µM -0.43216049670556 0.310193344828888 no 2326 0.332812384068353 753 870744
SGTC_291 SEC14.278 35.5 µM -0.432741045968909 0.309966589320256 no 2327 0.332601453444659 726 1068044
SGTC_1817 st052116 64.4 µM -0.433488716040005 0.30967466491782 no 2328 0.332329880983133 726 4361398
SGTC_3204 9114183 49.47 µM -0.433871454763646 0.309525272741672 no 2329 0.332190894758302 706 17027248
SGTC_2944 9067346 25.62 µM -0.434038331784916 0.309460146456059 no 2330 0.3321303029212 749 6473075
SGTC_1029 k015-0030 64.7 µM -0.434655481330357 0.309219346493667 no 2331 0.331906258530286 713 2208316
SGTC_2406 ethylparaben 405.7 µM -0.436641677276004 0.308444927301701 no 2332 0.331185616160509 745 8434 A possible steroid mimic.
SGTC_587 k089-0003 57 µM -0.436713460006308 0.308416955088141 no 2333 0.331159583244458 723 9659696
SGTC_1861 st057647 17.4 µM -0.437106325634796 0.308263883355088 no 2334 0.331017120008161 749 688668
SGTC_95 0471-0001 561.058 µM -0.437272387053953 0.308199191078044 no 2335 0.330956909197573 716 4015405
SGTC_3082 9117008 49.47 µM -0.437409983221157 0.308145592475976 no 2336 0.330907022674852 717 41448529
SGTC_1516 st013856 110 µM -0.438117241825356 0.307870154666859 no 2337 0.330650648157054 738 5281404 A mutagen and neurotoxin.
SGTC_787 4152-0075 138 µM -0.438579102027779 0.307690344257419 no 2338 0.330483271090158 701 9566539
SGTC_922 1866-0035 480 µM -0.440563365475862 0.30691836098087 no 2339 0.329764564664551 738 3156169
SGTC_2185 6113692 200 µM -0.441245181039563 0.306653295991699 no 2340 0.329517753791072 738 874150
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.441450990416521 0.306573304679305 no 2341 0.329443267299721 731 15053
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.442904439721597 0.306008659371102 no 2342 0.32891742798976 702 2724 A muscle relaxant with antifungal properties.
SGTC_3175 9106517 49.47 µM -0.444217627985263 0.305498899612829 no 2343 0.328442624286613 752 41468073
SGTC_1178 0988-0033 191 µM -0.444883833630632 0.305240432704254 no 2344 0.328201853069619 716 5392207
SGTC_2922 7999257 32.47 µM -0.445377616069694 0.305048923232293 no 2345 0.328023442798688 742 2988377
SGTC_1742 st038235 28.8875 µM -0.445410975350174 0.305035987033033 no 2346 0.328011391054007 763 564103 YBR002C RER2
SGTC_1721 st082152 9.2685 µM -0.447597574042173 0.304188590723047 no 2347 0.327221827143961 722 5296051
SGTC_902 1120-0002 2.07 µM -0.447844127117752 0.304093107161762 no 2348 0.327132847130932 743 3280475
SGTC_3281 9140613 49.47 µM -0.448325919460031 0.30390656014648 no 2349 0.326958998573423 710 16013766
SGTC_1442 4112-3290 3 µM -0.448659177870698 0.3037775544188 no 2350 0.326838768537107 761 704353
SGTC_3079 9117512 49.47 µM -0.448726814073131 0.303751375144315 no 2351 0.326814369537226 763 7185044
SGTC_2774 tamoxifen 10.92 µM -0.449854175426478 0.303315166887234 no 2352 0.326407795703286 741 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_722 3534-0461 190 µM -0.450915191070354 0.302904885626031 no 2353 0.326025337210831 717 658262
SGTC_2051 5263410 176 µM -0.451442656833731 0.302701013813186 no 2354 0.325835272574306 753 227584
SGTC_2280 7785178 200 µM -0.452512343916226 0.30228775584815 no 2355 0.325449965336292 718 2954328
SGTC_1922 5578187 25 µM -0.452650574648893 0.302234370899985 no 2356 0.325400187454615 694 1350412
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.453276631124081 0.301992639798327 no 2357 0.325174779019443 739 5282362
SGTC_2472 5377652 49.4 µM -0.453601345109398 0.301867296391726 no 2358 0.325057892592318 767 1610903
SGTC_999 SEC7.066 22.7 µM -0.454423686157961 0.301549967725348 no 2359 0.324761953704721 725 740511 YDR170C SEC7
SGTC_2964 9083345 53.42 µM -0.455434706834513 0.301160036333044 no 2360 0.324398265537686 728 17741579
SGTC_680 0417-1641 114 µM -0.456282711562857 0.300833152374633 no 2361 0.324093347176256 728 2835990
SGTC_3309 9129340 25.759 µM -0.456448613891068 0.300769220027896 no 2362 0.324033707212168 721 17158987
SGTC_1121 fusaric acid 630.51 nM -0.457612871719054 0.300320732620623 no 2363 0.323615297143294 719 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_839 0122-0028 230 µM -0.457927814913658 0.300199464322344 no 2364 0.323502151382287 767 759448
SGTC_4 0960-0234 25.671 µM -0.459230025171908 0.299698285853751 no 2365 0.323034495656549 723 6821112
SGTC_2802 7925815 54.55 µM -0.459680654073236 0.299524941725765 no 2366 0.322872728819474 739 1262923
SGTC_2996 9066192 71.4286 µM -0.459771309983587 0.299490074465665 no 2367 0.322840189193349 739 6472854
SGTC_1977 st070720 65.3 µM -0.461186575763984 0.298945986429443 no 2368 0.322332376027724 728 682188
SGTC_996 3970-0799 1.8 µM -0.461983741246907 0.298639720093328 no 2369 0.32204648997734 720 6615648 YGL040C HEM2
SGTC_2252 omeprazole 400 µM -0.462956083164896 0.29826634526485 no 2370 0.321697923231157 724 4594 A proton pump inhibitor.
SGTC_1058 3448-5425 97.3 µM -0.46369403334534 0.297983117740096 no 2371 0.32143348631772 759 7279705
SGTC_1694 st024011 44.9 µM -0.463843309500319 0.297925840007622 no 2372 0.321380005729266 767 2787533
SGTC_256 clotrimazole 625 nM -0.465349681415723 0.297348121450886 no 2373 0.320840531090666 723 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1123 mangostin 811.285 nM -0.465900350255641 0.297137058654188 no 2374 0.320643415218147 719 5281650 An antioxidant.
SGTC_1021 4476-0760 85.3 µM -0.465984271413188 0.297104898996091 no 2375 0.320613379475156 732 746768
SGTC_440 fluspirilene 35.1 µM -0.466108247938491 0.297057392522611 no 2376 0.320569009893189 751 3396 An atypical antipsychotic.
SGTC_1778 st046819 58.9 µM -0.467104939668698 0.296675597243626 no 2377 0.320212400123263 758 671715
SGTC_2985 9022375 71.43 µM -0.467151626880203 0.296657718632141 no 2378 0.3201956998124 774 4939335
SGTC_2258 7960471 200 µM -0.467410940878461 0.296558424742184 no 2379 0.320102948185563 773 2974708
SGTC_2931 9014674 55.67 µM -0.467729779268562 0.296436359249331 no 2380 0.319988921237955 741 2996810
SGTC_2101 5377231 179.231 µM -0.469587665743234 0.295725536318007 no 2381 0.31932481929107 761 2844213
SGTC_431 k089-0097 107 µM -0.470421151028868 0.295406901540511 no 2382 0.31902707786246 754 5499420
SGTC_1357 1503-1303 39.5 µM -0.471713814854497 0.294913039141065 no 2383 0.318565537515786 737 292895
SGTC_2690 usnic acid 100 µM -0.472629847275126 0.294563299338848 no 2384 0.318238642169299 776 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1930 st074634 34.3 µM -0.473025142636895 0.294412435297069 no 2385 0.318097620751443 772 684253 YOR116C RPO31
SGTC_2850 9015429 58.44 µM -0.473410761794797 0.294265298548991 no 2386 0.317960076720388 759 6457570
SGTC_1844 rapamycin 4 nM -0.474306504953146 0.293923650165556 no 2387 0.317640676745579 758 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2942 9052777 62.25 µM -0.474917216516311 0.293690821852511 no 2388 0.317422989795939 778 6469503
SGTC_933 2914-0560 114 µM -0.475203836684046 0.293581579921014 no 2389 0.317320846356541 733 463887
SGTC_3097 9117246 49.47 µM -0.475232235264678 0.293570757157958 no 2390 0.317310726651249 731 16423892
SGTC_17 0960-0276 49.807 µM -0.475484732533786 0.293474538004284 no 2391 0.317220756401811 755 6821114
SGTC_1026 k007-1105 30.6 µM -0.476879344055452 0.292943356623056 no 2392 0.316724020791316 741 7066794
SGTC_2396 5342950 42.78 µM -0.477486168149253 0.29271236808603 no 2393 0.316507984001458 755 1886677
SGTC_79 0052-0007 94.094 µM -0.47774123742156 0.292615300827126 no 2394 0.316417194904165 763 2801472
SGTC_2400 5203494 178.7 µM -0.479336600099234 0.29200852106715 no 2395 0.315849594299753 758 6777674
SGTC_320 4092-0846 5.34 µM -0.479620092636091 0.291900758928194 no 2396 0.315748778254739 752 1359356
SGTC_574 1315-0397 40 µM -0.47971572355047 0.291864411560898 no 2397 0.315714772935675 739 6794277
SGTC_765 1319-0117 244 µM -0.479970270861563 0.291767673576114 no 2398 0.315624266267395 721 3487746 YGL099W LSG1
SGTC_2936 9038235 15.59 µM -0.480894169940022 0.291416681194271 no 2399 0.315295858272107 736 4749415
SGTC_2397 5161689 200 µM -0.483716198195688 0.290345804776998 no 2400 0.314293647899941 770 2259942
SGTC_2580 diallyl disulphide 81.36 µM -0.485729960660168 0.289582769783434 no 2401 0.31357931919332 726 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_3273 9137859 49.47 µM -0.486929324293642 0.289128766557067 no 2402 0.313154208516897 762 2377234
SGTC_593 1203-0218 61.7 µM -0.486983935742126 0.289108102085722 no 2403 0.313134857564709 773 3666956
SGTC_2123 5259487 200 µM -0.487155725633509 0.289043102895257 no 2404 0.313073989105812 749 2173474
SGTC_1646 st011709 75.6 µM -0.487251548719081 0.289006849831345 no 2405 0.313040039358632 759 5757843
SGTC_1192 1488-0095 21.4 µM -0.487396716119642 0.28895193224535 no 2406 0.312988610131904 780 915875
SGTC_3306 9127676 59.7925 µM -0.488082229185636 0.28869266543415 no 2407 0.312745798949384 720 41905287
SGTC_1230 0170-0365 3.77 µM -0.488158225698972 0.28866392966039 no 2408 0.3127188857123 743 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2718 lomofungin 53.02 µM -0.48897539050444 0.288355028758263 no 2409 0.312429559886656 763 5351222 A RNA synthesis inhibitor.
SGTC_300 r073-0011 5.04 µM -0.490125072619934 0.287920695254388 no 2410 0.312022698533347 765 2735780
SGTC_2282 7944268 200 µM -0.490628043599572 0.287730777174382 no 2411 0.311844774025289 788 2970414
SGTC_323 4013-0906 34.3 µM -0.490762584056304 0.287679985739995 no 2412 0.311797188174341 742 2910086
SGTC_1505 k297-0037 20.6 µM -0.491983931263214 0.287219099200902 no 2413 0.311365351530744 735 4089396
SGTC_2096 5468907 200 µM -0.492863777254328 0.286887297982554 no 2414 0.311054421564375 744 759785
SGTC_529 4076-0302 30.3 µM -0.492882688814535 0.286880168184753 no 2415 0.311047739861736 750 5816522
SGTC_2467 5474540 200 µM -0.494797203069899 0.286158817049243 no 2416 0.310371639437142 732 5413519
SGTC_1232 0279-0259 161 µM -0.495224850974063 0.285997805567933 no 2417 0.310220705278566 752 1560000
SGTC_289 k017-0060 526 µM -0.500526958599609 0.284005121693988 no 2418 0.30835203932171 762 5512909
SGTC_778 3456-2434 196 µM -0.503267549849439 0.282977739783193 no 2419 0.307388088993537 750 5539063
SGTC_2981 9013952 38.96 µM -0.504630900485919 0.282467317771929 no 2420 0.306909051125694 732 2996344
SGTC_1759 st043059 70 µM -0.506802315013621 0.281655281718109 no 2421 0.306146765923195 782 669426
SGTC_679 0422-0091 41.4 µM -0.506851893258546 0.28163675427221 no 2422 0.306129371028808 781 627384 YHR062C RPP1
SGTC_168 3970-0862 530.542 µM -0.507113833980321 0.281538876486032 no 2423 0.306037474442949 773 3135186
SGTC_928 2764-0428 58.7 µM -0.50753974376209 0.281379764423008 no 2424 0.305888078701224 775 662578
SGTC_629 3448-6466 76.7 µM -0.509052673042642 0.280814913014849 no 2425 0.305357651962587 785 573744
SGTC_1193 1488-0126 41.5 µM -0.509749857672649 0.28055480413717 no 2426 0.305113359311741 732 1384710
SGTC_1480 1070-0044 41.2 µM -0.51056313362186 0.280251530778625 no 2427 0.304828498097449 759 3124987
SGTC_3050 9093513 49.47 µM -0.511380804077828 0.279946778875774 no 2428 0.304542216864516 774 25236664
SGTC_1155 4088-0394 48.2 µM -0.511661695097566 0.279842125783192 no 2429 0.304443899443542 755 2326248
SGTC_1382 3002-2117 298 µM -0.511749475379271 0.279809424899155 no 2430 0.30441317750355 796 1497314
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.512633844615413 0.279480073318811 no 2431 0.304103736963397 763 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2255 7941087 197.44 µM -0.515333555271866 0.278475829103432 no 2432 0.303159977334414 758 935561
SGTC_1578 josamycin 24.2 µM -0.515816908600192 0.278296216019081 no 2433 0.302991145954543 779 5282165 A P450 substrate.
SGTC_2082 5219693 150 µM -0.516216731453795 0.278147685375092 no 2434 0.302851522894163 767 2834649
SGTC_1481 3346-2004 36 µM -0.516944212539973 0.277877531817175 no 2435 0.30259755146961 786 2770522
SGTC_2455 5377712 9.75 µM -0.520484976539743 0.276564484098164 no 2436 0.301362798170052 733 2243908
SGTC_2449 5812982 45.77 µM -0.520791570177411 0.276450930951772 no 2437 0.301255988061323 776 776185
SGTC_3138 9097216 49.47 µM -0.521066015327615 0.276349304043719 no 2438 0.301160392204081 784 25237486
SGTC_2585 alliin 100 µM -0.524139997062145 0.275212263926692 no 2439 0.300090585552448 799 87310 A garlic compound which reacts with lipids.
SGTC_1150 3909-7983 10.9 µM -0.524264442367846 0.275166281203307 no 2440 0.300047312340126 769 23965914
SGTC_1112 tnp00069 1.16933 µM -0.524311188133467 0.275149009551641 no 2441 0.300031058222211 774 145826
SGTC_20 0481-0013 4.944 µM -0.525108698662041 0.274854427185849 no 2442 0.299753814711017 775 182045
SGTC_2128 5255449 168.493 µM -0.526045804668014 0.274508480168285 no 2443 0.299428191106876 746 736008
SGTC_1951 sophoraflavanone G 9.2 µM -0.526593388706532 0.274306430643366 no 2444 0.299237992040062 768 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_433 pimozide 108 µM -0.527656993587322 0.273914187836322 no 2445 0.298868713874051 760 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_53 0973-0023 39.979 µM -0.527722946259861 0.273889874533221 no 2446 0.298845822262937 791 674768
SGTC_2249 haloperidol 116.36 µM -0.530300645538715 0.272940448155046 no 2447 0.297951749595815 784 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3254 9136651 49.47 µM -0.530875570748604 0.272728912678068 no 2448 0.297752503733884 801 16454030
SGTC_457 grayanotoxin iii 135 µM -0.532786403038745 0.2720264343856 no 2449 0.297090723559116 784 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2055 5235184 200 µM -0.535096521798524 0.2711783698002 no 2450 0.296291557483475 816 2836034
SGTC_3291 9121177 71.43 µM -0.535294966034191 0.271105580734272 no 2451 0.296222953379647 772 17015612
SGTC_268 camptothecin 39.6153 µM -0.535698439476234 0.270957617295388 no 2452 0.296083491155605 791 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3038 9091290 49.47 µM -0.536798215573681 0.270554507587082 no 2453 0.295703502200496 790 25236843
SGTC_909 3448-9333 149 µM -0.537193787043803 0.270409588913501 no 2454 0.295566881211459 765 3344074
SGTC_406 estrone 100 µM -0.540368284093803 0.269248010116029 no 2455 0.294471537860109 781 5870 A steroid.
SGTC_2356 9061756 188.97 µM -0.541106354633486 0.26897830208098 no 2456 0.294217139234565 747 20104043
SGTC_570 0987-0065 62.6 µM -0.541769557646139 0.268736068109297 no 2457 0.293988632640018 758 3104428
SGTC_517 1365-0151 113 µM -0.542201636293 0.268578310966948 no 2458 0.293839804101931 772 768657
SGTC_1989 st071868 50.2 µM -0.543465655304779 0.268117069746885 no 2459 0.29340461578413 776 16414057
SGTC_1085 doxorubicin 7.67 µM -0.544737785933922 0.267653271464169 no 2460 0.292966936456898 788 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.545326578714793 0.267438744102658 no 2461 0.292764463623124 751 6708739 YPR165W RHO1
SGTC_3241 9133421 49.47 µM -0.545434381167472 0.267399475543353 no 2462 0.292727399778987 791 17018221
SGTC_1057 3448-5381 134 µM -0.546467442866135 0.267023315831509 no 2463 0.292372330674378 761 5497911
SGTC_1865 st057639 52.2 µM -0.546887139740384 0.266870571653067 no 2464 0.292228135731511 774 688818
SGTC_3118 9124250 49.47 µM -0.546973803610109 0.266839036766318 no 2465 0.292198364811885 784 1504786
SGTC_544 k015-0020 52.4 µM -0.548066390997974 0.266441632199943 no 2466 0.291823158433798 790 3008304
SGTC_1928 4'-methoxychalcone 40.3 µM -0.549293250331058 0.26599574632094 no 2467 0.291402109337431 786 641818
SGTC_1265 0819-1001 68.8 µM -0.550097255791531 0.265703746278843 no 2468 0.291126334404357 771 3106768
SGTC_1962 st076595 64.5 µM -0.550303369861734 0.26562891560856 no 2469 0.291055656639197 783 279619
SGTC_215 1287-0124 461.5 µM -0.550620540727552 0.265513786133578 no 2470 0.290946912484424 779 5560863
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.550853484132222 0.26542924641069 no 2471 0.290867058373019 768 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2302 7771753 200 µM -0.550994857916139 0.265377945757327 no 2472 0.290818599760782 761 2203047
SGTC_208 k072-0098 12.366 µM -0.551274637446231 0.26527643630503 no 2473 0.29072271101609 790 5948901
SGTC_3134 9127454 49.47 µM -0.554815891866485 0.263993306402838 no 2474 0.289510298011948 792 24262820
SGTC_24 0417-1663 219 µM -0.554876736333571 0.263971287831012 no 2475 0.289489487564563 799 4329390
SGTC_1013 4112-3890 241 µM -0.554999568353588 0.263926839876381 no 2476 0.289447477844527 783 705171
SGTC_1978 st071761 42 µM -0.555816167749021 0.26363144250275 no 2477 0.289168265904204 757 5147680
SGTC_1329 1447-1697 50.6 µM -0.557925733153244 0.262869107982661 no 2478 0.288447549338793 771 2840515
SGTC_1412 3909-8563 178 µM -0.558183007386039 0.262776213863448 no 2479 0.288359711559648 795 23767530
SGTC_1300 1094-0077 113 µM -0.558923947451433 0.26250877615315 no 2480 0.288106812560516 772 5532636
SGTC_2475 5812728 15.03 µM -0.559821928402071 0.262184842364114 no 2481 0.287800452445384 780 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2389 9091542 195.52 µM -0.560577474128007 0.26191244879266 no 2482 0.287542805581737 771 3626624 YOL127W RPL25
SGTC_3307 9126885 69.2785 µM -0.561001457983278 0.261759655353379 no 2483 0.287398271631982 771 24824909
SGTC_2952 9073731 13.78 µM -0.561282760190218 0.261658306140363 no 2484 0.287302396101551 795 16457353
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.561477661857722 0.261588097633153 no 2485 0.287235977128312 809 229346 A bile salt which induces apoptosis.
SGTC_2210 7115885 190.385 µM -0.56238689166846 0.261260697891662 no 2486 0.286926224074099 798 2927039
SGTC_1390 3413-2614 145 µM -0.562520236427917 0.261212700192217 no 2487 0.286880809984017 803 3421432
SGTC_2470 5664817 21.68 µM -0.564556925734833 0.260480153557066 no 2488 0.286187585163836 784 2859561
SGTC_1738 st035555 74 µM -0.564591377391816 0.260467771255543 no 2489 0.286175865752273 801 5331140
SGTC_3046 9092212 49.47 µM -0.564804234117269 0.260391274947765 no 2490 0.286103463388438 784 25236637
SGTC_2978 9011784 42.97 µM -0.564828722307424 0.260382475140646 no 2491 0.286095134386725 759 2994934
SGTC_1103 duloxetine 36.1 µM -0.565557644758303 0.260120607733764 no 2492 0.285847263712976 783 60835 A selective serotonin reuptake inhibitor.
SGTC_2702 st077768 96.8 µM -0.566030324730712 0.259950868738406 no 2493 0.285686583101943 750 6484119
SGTC_2984 9022109 38.96 µM -0.566752450877188 0.259691664169264 no 2494 0.285441189933928 812 6459207
SGTC_1186 1319-0216 26 µM -0.566913740145149 0.259633788200781 no 2495 0.285386394271653 791 4565136
SGTC_1838 st055369 84.5 µM -0.568825474158929 0.258948301828622 no 2496 0.284737292583978 748 676036
SGTC_2386 9075165 157.42 µM -0.568954252546477 0.258902159716073 no 2497 0.284693593085347 783 16452277
SGTC_1656 st012921 11 µM -0.569832730198164 0.258587509121267 no 2498 0.284395577007013 788 6732821
SGTC_1757 st041620 31.8375 µM -0.570234950358645 0.258443509177876 no 2499 0.284259177003072 791 5289815
SGTC_1604 st002052 72.4 µM -0.572147552021941 0.257759342247769 no 2500 0.283611008069097 757 6254834 YHR062C RPP1
SGTC_515 4092-1064 102 µM -0.572461173585246 0.257647244791358 no 2501 0.283504791260551 829 717353
SGTC_104 0074-0074 590.992 µM -0.57460110084966 0.256883048770392 no 2502 0.282780553689826 770 3943124
SGTC_1431 4049-0260 9.09 µM -0.575212362108569 0.256664976160723 no 2503 0.282573841582052 805 3854841
SGTC_1554 st069299 38.7 µM -0.576319811258465 0.256270130002796 no 2504 0.282199517210216 765 24207999
SGTC_2427 5545055 42.75 µM -0.576595328637223 0.256171947183269 no 2505 0.28210642779296 779 5372858
SGTC_3278 9139605 49.47 µM -0.576878272849375 0.256071138170941 no 2506 0.282010844452309 802 7958859
SGTC_349 k015-0014 24 µM -0.578425281453011 0.255520326997952 no 2507 0.281488514738265 776 2196908
SGTC_445 e6 berbamine 66 µM -0.578990871100444 0.255319103881461 no 2508 0.281297666461501 806 6610268 A calcium/calmodulin antagonist.
SGTC_3031 9088762 49.47 µM -0.580680539659983 0.254718454398261 no 2509 0.280727889872268 791 205253
SGTC_2571 chrysanthemic acid 100 µM -0.580895279646254 0.254642170879317 no 2510 0.280655516959409 825 2743 An insecticide.
SGTC_2062 5245942 200 µM -0.581448368211028 0.254445748644799 no 2511 0.280469153424325 781 1376160
SGTC_972 1319-0219 195 µM -0.585265146885608 0.253092436640828 no 2512 0.279184723089268 798 23903702
SGTC_495 decylubiquinone 155 µM -0.585283539715315 0.253085924290115 no 2513 0.279178540424707 810 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2974 9094440 9.66 µM -0.585603491499031 0.252972653041463 no 2514 0.279071000763868 768 25236134
SGTC_2597 laccaic acid a 100 µM -0.585634657231489 0.252961620988026 no 2515 0.279060526661292 791 5491415 A textile dye.
SGTC_1998 st075797 76.8 µM -0.586140774243525 0.25278250101255 no 2516 0.278890458867649 793 24208315
SGTC_1236 0330-0013 258 µM -0.586207183659079 0.252759002999632 no 2517 0.278868147409902 795 4617066
SGTC_1318 1280-3875 124 µM -0.586893955296032 0.25251606623477 no 2518 0.278637464865335 811 373245
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.587767644689333 0.252207187586015 no 2519 0.278344132112772 784 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.588087682406101 0.252094093346824 no 2520 0.27823672022649 777 17037758
SGTC_3280 9140961 49.47 µM -0.589864355267204 0.251466743335842 no 2521 0.277640796477735 814 4901226
SGTC_1400 3771-8998 51.5 µM -0.589952329298856 0.251435700819085 no 2522 0.277611304826435 775 670767
SGTC_792 4534-1957 155 µM -0.59212323309963 0.250670317765677 no 2523 0.276884035139423 775 1717904
SGTC_1954 st077032 68.9 µM -0.592172888795581 0.25065282538984 no 2524 0.276867411015153 829 698907
SGTC_2719 novobiocin 32.65 µM -0.593119352165415 0.250319535260422 no 2525 0.276550640051764 809 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1468 k284-1086 134 µM -0.593310861072961 0.250252125395515 no 2526 0.276486565728755 793 15996457
SGTC_983 1491-0821 12.2 µM -0.595175116855855 0.249596422977251 no 2527 0.27586321070592 776 46495113
SGTC_3110 9122132 49.47 µM -0.596888670020033 0.24899453214493 no 2528 0.27529085609617 773 918317
SGTC_1065 prochlorperazine maleate 2.48 µM -0.598212112254042 0.248530198118508 no 2529 0.274849205280866 831 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2297 7971671 152.32 µM -0.599279854362294 0.248155913845542 no 2530 0.274493139824999 801 909016
SGTC_1709 st033179 39.1045 µM -0.600071178288696 0.247878718759836 no 2531 0.274229399899571 797 573381
SGTC_402 epigallocatechin gallate 10 µM -0.60113404392076 0.247506664791135 no 2532 0.27387535503033 807 65064 An antioxidant.
SGTC_1880 MG-132 525 µM -0.601136082119883 0.247505951610399 no 2533 0.273874676315063 799 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2150 5556613 200 µM -0.605525927989114 0.2459724636657 no 2534 0.272414801159386 803 743190
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.605693026745204 0.245914192590682 no 2535 0.272359307707043 806 5106787 A p450 inhibitor.
SGTC_2849 9019321 12.99 µM -0.608338996361004 0.244992472000652 no 2536 0.271481331121821 786 16489627
SGTC_1994 st072947 40.9 µM -0.608451025216072 0.24495348792813 no 2537 0.271444189222485 821 5286565 YDL195W SEC31
SGTC_1344 1488-0097 29.1 µM -0.609467250867957 0.244600011773787 no 2538 0.271107386782952 822 747966
SGTC_944 3370-0224 231 µM -0.609543493320767 0.24457350326539 no 2539 0.271082126545975 779 4580514
SGTC_2855 9016525 58.44 µM -0.609578550517606 0.244561314853735 no 2540 0.271070511979162 806 43811474
SGTC_3070 9117005 49.47 µM -0.609827076377427 0.24447491871077 no 2541 0.270988181645947 800 8779016
SGTC_2177 5811945 192 µM -0.609978122866316 0.244422417787367 no 2542 0.270938149859191 798 5343475
SGTC_2618 avocadyne 43.43 µM -0.611381577091668 0.243934894046329 no 2543 0.270473498083123 805 3015189
SGTC_3227 9130768 49.47 µM -0.612581510931321 0.243518484445067 no 2544 0.270076543281337 807 17720899
SGTC_1268 0828-0275 2.46 µM -0.613563129671183 0.243178121845113 no 2545 0.269752027038087 807 745337
SGTC_949 1165-0505 146 µM -0.614178041912875 0.242965040700106 no 2546 0.269548840905118 791 6244267
SGTC_78 0336-0123 156.75 µM -0.614386132123306 0.242892955566633 no 2547 0.269480098798706 803 6765896
SGTC_2621 lithochol-11-enic acid 100 µM -0.617700904218743 0.241746237613592 no 2548 0.268386257917786 825 6708711
SGTC_2771 fluoxetine 41.05 µM -0.618081307998937 0.24161482828169 no 2549 0.268260871536313 811 3386 A selective serotonin reuptake inhibitor.
SGTC_1293 1000-1278 195 µM -0.618251030484619 0.241556210678119 no 2550 0.268204938151505 816 678847
SGTC_31 0508-1974 57.237 µM -0.620205216011414 0.240881843971381 no 2551 0.267561343947393 785 6810525
SGTC_1151 3909-8316 15.3 µM -0.621436285240728 0.240457542682037 no 2552 0.267156302018994 812 800431
SGTC_1866 st057638 64 µM -0.621477492603972 0.240443347163613 no 2553 0.267142749477495 794 688802
SGTC_1583 clindamycin 39.6 µM -0.621630355887341 0.240390691301192 no 2554 0.267092477853884 804 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2700 st077718 96.8 µM -0.622082666427347 0.240234923505178 no 2555 0.266943756019075 797 904970
SGTC_993 3909-8757 62.7 µM -0.623453397634374 0.239763203877887 no 2556 0.266493308753699 805 4288324 YLR208W SEC13
SGTC_400 oxethazaine 37.5 µM -0.62471475646586 0.239329570249372 no 2557 0.266079143186253 806 4621 A local anesthetic.
SGTC_1502 4534-4282 27.7 µM -0.625125335616283 0.239188512623439 no 2558 0.265944400402497 824 3278949
SGTC_1472 k841-0093 193 µM -0.625312410112634 0.239124256809886 no 2559 0.265883018253487 824 X1472
SGTC_2703 st077852 53.4 µM -0.625920912744197 0.238915315332176 no 2560 0.265683408427518 825 6281836
SGTC_1466 k213-0079 57.5 µM -0.62666321357838 0.238660566819115 no 2561 0.265440011105876 836 3657981
SGTC_2226 7298446 200 µM -0.627776969993155 0.238278618307761 no 2562 0.265075027421567 816 3283010
SGTC_3276 9139060 49.47 µM -0.628068074090701 0.23817884310565 no 2563 0.264979673158136 819 4870619
SGTC_2245 6637752 200 µM -0.629275033128557 0.237765405227844 no 2564 0.264584506833106 795 681890
SGTC_2883 9059145 45.46 µM -0.629900163329268 0.237551424794236 no 2565 0.264379953010062 827 16476510
SGTC_1168 k815-0004 80.5 µM -0.631808609838842 0.236898822863859 no 2566 0.263755973462668 820 642433
SGTC_2924 9010168 62.78 µM -0.632094055320292 0.236801298293718 no 2567 0.263662709733805 813 2993929
SGTC_225 nsc-122657 1.016 µM -0.632336728653438 0.236718404512128 no 2568 0.263583434200689 811 275685
SGTC_190 3970-0790 3.722 µM -0.632397935319751 0.236697499700447 no 2569 0.263563441377758 806 2832352
SGTC_2345 9052315 157.45 µM -0.63251173589124 0.236658634419253 no 2570 0.263526271100239 800 6469265
SGTC_1683 st010134 710 nM -0.63411312852539 0.236112097705369 no 2571 0.263003497747381 829 3818134
SGTC_1286 0929-0070 131 µM -0.634135980415878 0.236104303655634 no 2572 0.262996041603757 810 1420408
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.63466047687683 0.235925453635701 no 2573 0.262824937941641 800 6312947
SGTC_1190 1486-1332 13 µM -0.634934409174124 0.235832074123956 no 2574 0.262735597116327 818 4150046
SGTC_2674 ligustilide 100 µM -0.635068837979386 0.235786256765467 no 2575 0.262691759921001 792 5319022 A signalling regulator.
SGTC_596 1155-0152 116 µM -0.635095775090079 0.235777076382573 no 2576 0.262682976186894 818 280313
SGTC_550 4123-0385 25.7 µM -0.635360132527297 0.235686991711097 no 2577 0.26259678169257 815 5731123
SGTC_2301 7769476 200 µM -0.637543254240379 0.234943778862196 no 2578 0.261885522379285 823 977820
SGTC_2149 5554786 194.827 µM -0.638288767702096 0.234690276316322 no 2579 0.261642861180723 808 745063 YPR165W RHO1
SGTC_2151 5563267 85.4165 µM -0.639116245783537 0.234409079914646 no 2580 0.261373656059067 821 5310824
SGTC_853 0419-0306 21 µM -0.640646252496237 0.233889639244701 no 2581 0.260876270845013 815 762713
SGTC_651 3253-0966 34.4 µM -0.641419252597611 0.233627446705791 no 2582 0.260625163846564 809 781462
SGTC_2023 5144124 124 µM -0.641650964011338 0.233548884679457 no 2583 0.260549917262439 813 2830192
SGTC_895 0964-0006 13.7 µM -0.641840006469812 0.233484800466319 no 2584 0.260488535395191 828 6738897
SGTC_2129 girgensonine 121.053 µM -0.643549127624036 0.232905861986901 no 2585 0.259933923925166 819 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_819 1013-0258 27.7 µM -0.643810302999732 0.232817463141242 no 2586 0.259849225941448 819 5753198
SGTC_2622 2-methoxyxanthone 59.94 µM -0.645360938554815 0.232293010638073 no 2587 0.259346655275706 804 71034 A hepatoprotective.
SGTC_2156 5649887 115 µM -0.645418924896653 0.232273411384511 no 2588 0.259327871286257 813 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_370 0180-0345 38.7 µM -0.645554162956785 0.232227704798818 no 2589 0.25928406524829 795 3989527
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.645726516776388 0.2321694614054 no 2590 0.259228242291518 823 616764
SGTC_2814 7977482 42.97 µM -0.646349200453063 0.231959106148562 no 2591 0.25902661565607 814 6456762
SGTC_1416 3966-0321 25.3 µM -0.648954631527319 0.231080090417554 no 2592 0.258183850599034 816 582530 YLR208W SEC13
SGTC_1376 2910-0861 41.3 µM -0.64902634300554 0.231055922843204 no 2593 0.258160674582777 829 1112859
SGTC_2444 5485484 36.41 µM -0.649456554684329 0.230910966292966 no 2594 0.258021659616735 837 6790631
SGTC_309 k408-0051 1.48 µM -0.64972976855058 0.230818935329527 no 2595 0.257933395759274 820 3640463
SGTC_1679 SEC14.276 6.7 µM -0.650302595656523 0.230626047396922 no 2596 0.257748390384635 815 1005053 YMR079W SEC14
SGTC_580 1123-0028 41 µM -0.652547816527555 0.229870883706358 no 2597 0.257023918376291 832 1677248 YPR107C YTH1
SGTC_2887 9044784 58.44 µM -0.653149222673253 0.229668840440307 no 2598 0.256830040907981 812 6465546
SGTC_1722 st034304 3.6505 µM -0.654922647311217 0.229073635351275 no 2599 0.25625877906734 827 4036148 YLR033W RSC58
SGTC_703 3875-0075 71.8 µM -0.655969129158653 0.228722816557409 no 2600 0.255921993651152 847 2850814
SGTC_1437 4092-1038 11.6 µM -0.656364065589751 0.228590497939371 no 2601 0.255794952764173 826 3977136
SGTC_97 0535-0701 19.132 µM -0.656895703114201 0.228412447202439 no 2602 0.255623990651321 804 2832013 YGL099W LSG1
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.657237055117001 0.228298166087484 no 2603 0.255514251350334 818 140250 A respiratory chain inhibitor.
SGTC_2365 9042475 200 µM -0.658713701304145 0.227804170622455 no 2604 0.255039816493012 815 6464479
SGTC_77 0828-0286 12.516 µM -0.659525780241341 0.227532755278981 no 2605 0.254779098435598 806 745345
SGTC_331 k048-0133 24.5 µM -0.65992057390372 0.227400872027072 no 2606 0.254652400298668 810 6813582
SGTC_3120 9124077 49.47 µM -0.660004586112284 0.227372812789841 no 2607 0.254625443156131 833 18774327 YGL155W CDC43
SGTC_1953 st076800 12.1 µM -0.660980034574425 0.227047165597618 no 2608 0.254312558777531 815 297591
SGTC_2200 6600604 21.907 µM -0.66130189075061 0.226939773711806 no 2609 0.254209364586184 847 2904777
SGTC_1887 st057648 70.8 µM -0.663231579366528 0.226296506794288 no 2610 0.2535911246085 828 688672
SGTC_3245 9134821 49.47 µM -0.664234123589114 0.225962712961004 no 2611 0.253270238241102 838 17014901
SGTC_509 pifithrin 175 µM -0.664448221364053 0.225891465891441 no 2612 0.25320173920512 834 4817 A p53 inhibitor.
SGTC_1267 0828-0272 9.49 µM -0.665815622345906 0.225436724436359 no 2613 0.252764479062445 821 745334
SGTC_2482 5981709 142.65 µM -0.66623361499424 0.225297820725206 no 2614 0.252630895006659 835 877755
SGTC_3115 9123671 49.47 µM -0.666685069068131 0.225147851859919 no 2615 0.252486658972539 831 3286988
SGTC_2992 9074591 71.4286 µM -0.667361108586495 0.224923383575807 no 2616 0.252270750821805 830 17741321
SGTC_1888 azatryptophan 97.5 µM -0.668066268054049 0.224689381696162 no 2617 0.252045646343405 805 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_613 3914-0030 117 µM -0.668130879834742 0.224667947668892 no 2618 0.252025025953813 802 1145395
SGTC_2723 salbutamol 83.58 µM -0.668960276278764 0.224392910362741 no 2619 0.251760409054678 826 9884233 β2-adrenoceptor agonist
SGTC_3123 9126162 49.47 µM -0.669987316040075 0.224052597273052 no 2620 0.25143293796158 806 25239884
SGTC_297 0986-0032 24 µM -0.670096260276776 0.224016515440188 no 2621 0.251398214359567 822 2847425
SGTC_1490 4089-0339 670 nM -0.670164865859704 0.223993795278998 no 2622 0.251376349125364 827 742542
SGTC_2586 curcumin 80 µM -0.670566895450702 0.22386068116208 no 2623 0.251248238781824 821 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3112 9123419 49.47 µM -0.670638726919677 0.223836902118988 no 2624 0.251225352674301 844 17015854
SGTC_2173 5763948 167 µM -0.671576051678968 0.223526742356872 no 2625 0.250926814234934 820 2867177
SGTC_2710 st078562 53.7235 µM -0.671774680903936 0.223461047562575 no 2626 0.250863574838847 836 17250908
SGTC_2812 7970281 58.44 µM -0.672991868393099 0.223058713934881 no 2627 0.250476232097146 835 2233435
SGTC_339 3091-4833 71.4 µM -0.673241801725931 0.222976151129718 no 2628 0.250396735633186 824 3240077
SGTC_573 3702-0553 84.7 µM -0.6739781738661 0.222732999678334 no 2629 0.250162595016051 815 1222756
SGTC_1166 k206-0078 225 µM -0.674529135357128 0.222551170042395 no 2630 0.249987484484749 815 5404595
SGTC_1470 k295-0292 231 µM -0.674675735148825 0.222502803086395 no 2631 0.249940902046334 835 5045612
SGTC_483 fpl-64176 144 µM -0.67482498845725 0.222453566826954 no 2632 0.249893481179522 835 3423
SGTC_2845 9003024 42.97 µM -0.674987389681205 0.222400000341689 no 2633 0.249841888373296 802 2990173
SGTC_712 r015-0009 80.6 µM -0.675276940342468 0.222304513089567 no 2634 0.249749915836242 828 6813872 YLR060W FRS1
SGTC_1104 tacrolimus 29.8 µM -0.67605253450321 0.222048854965141 no 2635 0.249503645606203 826 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_978 1416-0512 87.4 µM -0.680891486904706 0.220457592484059 no 2636 0.247970077590341 845 6814003
SGTC_1801 st050089 28.441 µM -0.681229963666467 0.220346531384374 no 2637 0.247862995574094 812 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1338 1486-1223 76 µM -0.683139275613678 0.219720648423558 no 2638 0.247259419747707 822 3444526
SGTC_3303 9125618 40.5795 µM -0.68363500043544 0.219558314163192 no 2639 0.247102838747536 818 22695467
SGTC_2199 6590217 200 µM -0.683773862022426 0.219512853722468 no 2640 0.247058987057839 800 703109
SGTC_772 k072-0172 35.3 µM -0.684575359423848 0.219250565575092 no 2641 0.246805960176488 807 5861980
SGTC_1839 st053978 48 µM -0.685616604150967 0.218910089850462 no 2642 0.246477454105015 834 3788398
SGTC_3255 9139072 49.47 µM -0.686659235370515 0.218569465726666 no 2643 0.246148745507586 834 17646060
SGTC_401 neomycin 50 µM -0.687105201887579 0.21842386318736 no 2644 0.246008218211705 812 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1909 st060837 51.5 µM -0.68723733650375 0.218380733603547 no 2645 0.245966589899726 826 678937
SGTC_800 3448-7362 155 µM -0.688063294641121 0.218111246776715 no 2646 0.245706461835453 843 15991913
SGTC_1512 0259-0544 12.2 µM -0.690317001758355 0.217376901574051 no 2647 0.244997429188083 821 18476
SGTC_541 4513-1321 94 µM -0.690985535958271 0.217159342056853 no 2648 0.244787315359679 823 747515
SGTC_61 0978-8327 98.565 µM -0.691987358360588 0.216833556945582 no 2649 0.244472633954646 844 6150059 YHR072W ERG7
SGTC_2164 5685496 200 µM -0.693381852136297 0.216380548803094 no 2650 0.244034974027364 847 759046
SGTC_806 3966-4455 5.86 µM -0.693537355161787 0.216330066852737 no 2651 0.24398619582485 830 714982
SGTC_1368 1852-0141 284 µM -0.693580366528841 0.2163161049989 no 2652 0.243972704944185 835 2838987
SGTC_602 3130-1533 38.1 µM -0.694098936795508 0.216147813761694 no 2653 0.243810082655014 844 720941
SGTC_481 bay k-8644 50 µM -0.695244368823645 0.21577635634894 no 2654 0.243451085577483 844 2303 A calcium channel antagonist.
SGTC_755 1995-0008 37.3 µM -0.695262697638426 0.215770415422768 no 2655 0.2434453433504 811 689533
SGTC_26 0302-0163 425.158 µM -0.695914076977576 0.215559345138434 no 2656 0.243241320493719 866 3100915
SGTC_70 0141-0289 43.283 µM -0.696238313268081 0.215454325594416 no 2657 0.243139798752829 822 352408
SGTC_2267 7931562 200 µM -0.696382850539364 0.215407519801286 no 2658 0.243094550020264 822 934880
SGTC_3188 9110789 49.47 µM -0.69687978220264 0.215246642440393 no 2659 0.242939015704997 842 849217
SGTC_1413 3910-0535 34.4 µM -0.697435607202346 0.215066781511421 no 2660 0.24276511220798 828 2876951
SGTC_2715 st079500 56.4 µM -0.69949310623894 0.214401749612736 no 2661 0.242121959871129 833 28246688
SGTC_3161 9100388 49.47 µM -0.700921760100799 0.213940679521635 no 2662 0.241675921883133 845 25236368
SGTC_1428 4049-0204 61.7 µM -0.705580280785222 0.212441248843397 no 2663 0.240224595393139 848 X1428
SGTC_1362 1611-0397 101 µM -0.705720673837131 0.212396156265164 no 2664 0.240180930860134 839 27816
SGTC_861 0443-0273 110 µM -0.705898109668368 0.212339173988244 no 2665 0.240125751606273 844 6149169
SGTC_1510 1123-0200 71.5 µM -0.705978627804208 0.212313319098849 no 2666 0.240100714238359 852 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1972 st070201 17.4 µM -0.706079502806504 0.212280930085696 no 2667 0.240069348847114 832 2829099
SGTC_1783 st039459 87.517 µM -0.706762691770251 0.212061647338953 no 2668 0.239856981496237 864 729761
SGTC_2405 ticlatone 3.52 µM -0.707716166104156 0.211755832796468 no 2669 0.239560768093472 837 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3072 9116419 49.47 µM -0.707798514829819 0.211729432622065 no 2670 0.239535194400061 829 17170162
SGTC_1695 st026914 34.495 µM -0.708397779207403 0.211537372500515 no 2671 0.239349135585307 837 3289191
SGTC_140 0062-0056 502.533 µM -0.708624554648774 0.21146471913951 no 2672 0.239278747239166 829 3758964
SGTC_1341 1486-1360 280 µM -0.708924802053602 0.211368549624105 no 2673 0.239185571487727 854 3976547
SGTC_2755 lomerizine 42.69 µM -0.709060178225559 0.211325196894126 no 2674 0.239143566697984 838 3949 A calcium channel blocker.
SGTC_204 PMA1.184 62.41 µM -0.709462505660398 0.211196386704839 no 2675 0.239018755533685 837 2252213 YGL008C PMA1
SGTC_2138 5575593 77.673 µM -0.709493707867015 0.211186398848599 no 2676 0.239009077384414 842 762213
SGTC_820 1582-0060 59.9 µM -0.709810054766119 0.211085151532473 no 2677 0.238910966534418 846 3848840
SGTC_734 2023-0417 80 µM -0.710681196222785 0.210806488441928 no 2678 0.238640907279462 852 3935732
SGTC_2628 lathosterol 100 µM -0.711055881211162 0.210686699579438 no 2679 0.238524804008011 823 6710616
SGTC_3267 9137951 49.47 µM -0.713119541508028 0.210027651995605 no 2680 0.237885894101414 871 16643986
SGTC_257 daunorubicin 18.5 µM -0.715238901238829 0.209352078748616 no 2681 0.237230717576339 831 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1970 st070122 35.8 µM -0.717132611282589 0.208749517482561 no 2682 0.236646137632082 856 102928
SGTC_305 1682-2595 20.8 µM -0.717180970064862 0.20873414355426 no 2683 0.23663121987311 841 226033
SGTC_1125 tnp00248 1.32998 µM -0.721460154745195 0.207376375150007 no 2684 0.235313223665033 861 24207736
SGTC_1840 st055363 71 µM -0.721753471166769 0.207283498621667 no 2685 0.235223030357158 851 676033
SGTC_421 streptovitacin 30 mM -0.721882192450309 0.207242747723022 no 2686 0.235183455244617 867 91467 include heat shock
SGTC_975 1335-0046 28.5 µM -0.72262311240128 0.207008277610989 no 2687 0.234955732330719 855 16486740
SGTC_508 roscovitine 141 µM -0.722847050047749 0.20693744163327 no 2688 0.234886928727489 863 160355 A CDKinase inhibitor.
SGTC_2174 5790901 200 µM -0.724654762962105 0.206366151190644 no 2689 0.234331926872167 855 786020
SGTC_2313 7726885 200 µM -0.724868469638949 0.2062986754257 no 2690 0.234266362911068 855 726423
SGTC_296 1222-0039 74.9 µM -0.72487106519508 0.206297855984958 no 2691 0.234265566672015 827 5984176
SGTC_1571 st070080 73.4 µM -0.725736193783252 0.206024834493947 no 2692 0.234000254556515 848 4315245
SGTC_3282 9108498 15.4605 µM -0.727195421135161 0.20556481026725 no 2693 0.233553125395455 848 16459645
SGTC_591 4299-0174 154 µM -0.730068482712118 0.204660856364287 no 2694 0.232674162630144 858 5509088
SGTC_1477 0139-0234 16 µM -0.730285891780093 0.20459254913745 no 2695 0.232607725054922 845 620880
SGTC_877 0771-0151 33.1 µM -0.733149444069447 0.203694123221527 no 2696 0.231733643111884 844 6166523
SGTC_1148 3909-7663 27.7 µM -0.734606661992839 0.203237832546717 no 2697 0.231289539767686 866 4084526
SGTC_1440 4100-1550 40 µM -0.736293011874164 0.20271055723115 no 2698 0.230776199035672 854 742806
SGTC_2442 5158906 48.48 µM -0.737152262475687 0.202442207818011 no 2699 0.230514880019154 841 1893835
SGTC_1606 st000094 49.2 µM -0.738031081766694 0.202167966817854 no 2700 0.23024778085079 830 1242210
SGTC_2972 9093619 59.92 µM -0.738805595473758 0.201926459384237 no 2701 0.230012526801347 835 25236256
SGTC_1082 camptothecin 424.86 nM -0.738856302955965 0.201910653896765 no 2702 0.22999712939065 848 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1900 st060200 72.8 µM -0.739352596555625 0.201755998622749 no 2703 0.22984645947504 852 688945
SGTC_849 0386-0493 241 µM -0.740219797200374 0.201485931439167 no 2704 0.229583318472924 860 726119
SGTC_2188 6126565 140.678 µM -0.740522313875281 0.201391771443076 no 2705 0.229491563359755 834 874518
SGTC_3352 9151559 45.5865 µM -0.740854772788312 0.201288322183353 no 2706 0.229390750291942 834 17159339
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.741650633223872 0.20104080847474 no 2707 0.229149518682189 833 688669
SGTC_3135 9127742 49.47 µM -0.742679472549076 0.200721108694618 no 2708 0.228837880282221 857 3643468
SGTC_2730 imipramine 71.33 µM -0.743020907786712 0.200615079169549 no 2709 0.228734511161105 838 3696 A tricyclic antidepressant.
SGTC_3198 9112019 49.47 µM -0.744105337768581 0.200278542650506 no 2710 0.22840637516271 891 45595555
SGTC_2348 9022543 33.42 µM -0.744418024591733 0.200181568044839 no 2711 0.228311808892143 843 3162678 YDL140C RPO21
SGTC_2882 9058044 58.44 µM -0.74548992137861 0.199849351365288 no 2712 0.227987800864988 836 18076804
SGTC_2040 5100729 123 µM -0.746441131754431 0.199554817320513 no 2713 0.227700490104215 846 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1711 st032263 62.8 µM -0.748622032936418 0.1988805070573 no 2714 0.227042524206598 863 3958979
SGTC_396 dithiazanine 1.25 µM -0.750300446462726 0.198362496757564 no 2715 0.226536886894839 846 10578 An antihelmenthic.
SGTC_3294 9122953 26.2835 µM -0.753139100003493 0.197488255672637 no 2716 0.225683165311844 862 16459826
SGTC_855 0428-0020 25 µM -0.754322589674785 0.197124456802606 no 2717 0.225327770595076 848 6812414
SGTC_836 0330-0104 1.35 µM -0.755365621658077 0.19680417036415 no 2718 0.225014817365029 837 46494820
SGTC_3092 9117248 49.47 µM -0.755997214180064 0.196610378946096 no 2719 0.224825432986336 880 17141857
SGTC_2091 4-phenylthiadiazole 200 µM -0.757139450390014 0.196260200537895 no 2720 0.224483160613976 853 270010
SGTC_2818 7996756 12.99 µM -0.758531030039603 0.195834091582786 no 2721 0.224066572029749 884 2241621
SGTC_2874 9043904 71.43 µM -0.758833825416466 0.195741448483514 no 2722 0.223975984260598 868 4463428
SGTC_469 w7 172 µM -0.759384975812825 0.195572887118913 no 2723 0.223811149150098 846 45115570 A P450 inhibitor.
SGTC_3085 9117376 49.47 µM -0.761224810296053 0.19501083890476 no 2724 0.22326140085188 856 16480349
SGTC_1620 st003704 16.5 µM -0.761559197267283 0.194908793101778 no 2725 0.223161567582135 855 2834414
SGTC_2813 7971799 71.43 µM -0.763085235936916 0.194443500018263 no 2726 0.222706282217568 866 2234054
SGTC_1673 st016611 27.3 µM -0.764388286529011 0.194046732224733 no 2727 0.222317943508297 870 5226799
SGTC_801 0866-0028 10.1 µM -0.766308551657391 0.193462927714538 no 2728 0.221746365572216 847 6849771
SGTC_1389 3405-0187 19 µM -0.766639495903375 0.193362421449321 no 2729 0.221647942999979 845 799890
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.766733215168879 0.193333965123502 no 2730 0.221620075496525 859 6710655
SGTC_2152 5568786 200 µM -0.767275184642417 0.193169455059739 no 2731 0.221458959687296 867 5399883
SGTC_3290 9121031 71.43 µM -0.767524259967941 0.193093879104896 no 2732 0.221384937441884 850 17014854
SGTC_223 busulfan 5 mM -0.767969692968552 0.192958768124073 no 2733 0.221252595294116 846 2478 A DNA alkylator.
SGTC_748 act1.228 77.9 µM -0.770494526252407 0.192194014667795 no 2734 0.220503300378036 849 4421505 YNR035C ARC35
SGTC_2385 9074692 200 µM -0.770515535312707 0.19218765896609 no 2735 0.220497071624408 859 17046906
SGTC_3337 9144342 33.5465 µM -0.770525771337139 0.192184562390692 no 2736 0.220494036890539 840 17682949
SGTC_1033 k072-0102 21.3 µM -0.771236027254575 0.191969772165831 no 2737 0.220283521633604 858 5965931
SGTC_2634 4'-methoxyflavone 100 µM -0.772174769018582 0.191686110504103 no 2738 0.220005461535414 860 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2497 7-hydroxyflavone 100 µM -0.772840228895116 0.191485182596193 no 2739 0.219808470960071 877 5281894
SGTC_1064 honokiol 6.76 µM -0.773706254437174 0.191223889530207 no 2740 0.219552260272708 868 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2875 9039966 71.43 µM -0.773794861517144 0.191197167759237 no 2741 0.219526055848289 876 6463691
SGTC_1960 st011366 51.8 µM -0.778087968802719 0.189905213338013 no 2742 0.218258577465824 868 3972846
SGTC_1761 st044296 37 µM -0.779051615077829 0.189615955875859 no 2743 0.217974655258196 879 1826700
SGTC_1684 st024538 14.6195 µM -0.779931855045811 0.189351971469151 no 2744 0.217715493521503 864 6732859
SGTC_2424 5537928 59.2 µM -0.780309335605023 0.189238834202029 no 2745 0.217604409544879 864 5382802
SGTC_151 3013-0144 2.285 µM -0.781897769420536 0.188763210103028 no 2746 0.217137328010613 880 906558 YHR107C CDC12
SGTC_1330 1469-0054 61.8 µM -0.782193798218629 0.188674651835058 no 2747 0.217050344340445 861 7102664
SGTC_2194 5927483 104.545 µM -0.782584163892935 0.188557911452706 no 2748 0.216935671967474 832 760979
SGTC_2529 gangaleoidin 93.61 µM -0.782847920377622 0.18847905926207 no 2749 0.21685821166838 874 4565183
SGTC_997 3996-0078 137 µM -0.782898104553357 0.188464058589136 no 2750 0.216843475334414 860 735687
SGTC_966 1300-0360 30.2 µM -0.784329467489474 0.188036516480933 no 2751 0.216423406528046 852 70588
SGTC_1159 4092-0538 61.2 µM -0.784799820971353 0.187896154664174 no 2752 0.2162854725537 889 717301
SGTC_93 0109-0045 59.227 µM -0.786067487500338 0.187518182762723 no 2753 0.215913975274915 878 88733
SGTC_957 1187-1561 14.1 µM -0.78609946496701 0.187508654328791 no 2754 0.215904608870028 861 1538454
SGTC_285 1486-1325 46 µM -0.78738202112918 0.187126733428021 no 2755 0.215529134088385 871 22310230
SGTC_3130 9127414 49.47 µM -0.788940908371716 0.186663174679329 no 2756 0.21507327227588 869 1494646
SGTC_2526 patulin 37.61 µM -0.789568292687147 0.186476813259008 no 2757 0.214889965825501 876 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1204 4049-0315 18.3 µM -0.795170815447001 0.184817724872377 no 2758 0.213257072946597 885 588402
SGTC_2035 5154463 94.595 µM -0.79562671028833 0.184683124512905 no 2759 0.213124518425678 866 2769623
SGTC_2925 9010536 32.5 µM -0.797927985879502 0.184004616682985 no 2760 0.212456140902704 827 2994177
SGTC_2262 9014885 67.46 µM -0.798067443252263 0.183963549026239 no 2761 0.212415676595852 864 6457424
SGTC_1037 k284-1091 78.7 µM -0.799011016821825 0.183685833764135 no 2762 0.212142011976603 864 3334711
SGTC_1217 1183-1422 255 µM -0.799054834570289 0.183672943549467 no 2763 0.212129308526605 865 2849664
SGTC_3145 9085516 49.47 µM -0.799502114189103 0.183541395997977 no 2764 0.211999660619595 880 25236195
SGTC_3043 9092303 49.47 µM -0.800166060593701 0.183346233783561 no 2765 0.211807295427662 850 25236084
SGTC_376 3970-0862 59.1 µM -0.800527257498932 0.183240116943278 no 2766 0.211702688756127 884 3135186
SGTC_88 0180-0332 8.668 µM -0.801952794158295 0.1828216793749 no 2767 0.211290132625051 866 3101745
SGTC_3067 9117431 49.47 µM -0.802004913951202 0.182806391970143 no 2768 0.211275057874362 901 17150885
SGTC_1772 st048439 82.2 µM -0.803161434736322 0.182467374892163 no 2769 0.210940716341154 860 2927068 YDL195W SEC31
SGTC_2120 5538279 151.968 µM -0.805654510043193 0.181737903354547 no 2770 0.210221042887335 866 2058197
SGTC_1667 st014849 34.6 µM -0.806126039343313 0.181600139768179 no 2771 0.210085089357002 873 5348460
SGTC_217 ketoconazole 989 nM -0.806392960368506 0.181522184199702 no 2772 0.210008152341698 838 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_150 3970-0969 77.2 µM -0.806397041742211 0.181520992377499 no 2773 0.210006976059668 896 6615640
SGTC_2349 9023730 187.07 µM -0.806931317339589 0.18136501819528 no 2774 0.209853027315159 887 4126287
SGTC_2725 haloperidol 53.21 µM -0.807146975116908 0.181302083745165 no 2775 0.209790905441402 864 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_622 1348-1566 26.3 µM -0.807924084778818 0.181075416732281 no 2776 0.209567142740935 873 7340407
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.808234945498106 0.180984794747291 no 2777 0.209477672132147 892 65057 A dermal irritant. YDR527W RBA50
SGTC_2477 5967686 25.23 µM -0.80930859926574 0.180672022289859 no 2778 0.209168830568353 882 776118
SGTC_2081 5214970 32.255 µM -0.810828547798597 0.180229816978587 no 2779 0.208732068910868 885 2063512
SGTC_955 1216-0110 33 µM -0.811518803295508 0.180029222391123 no 2780 0.208533899572694 879 3619719
SGTC_1780 st038448 24.544 µM -0.814519199135418 0.179158909715945 no 2781 0.207673789048882 883 728868 YDL195W SEC31
SGTC_2566 crystal violet carbinol 226 nM -0.817253115686 0.178368202096857 no 2782 0.206891896953377 906 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1063 disulfiram 1.84 µM -0.820234795226024 0.177508346903061 no 2783 0.20604113485242 893 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2000 st075254 36.4 µM -0.820902394365997 0.177316184082498 no 2784 0.205850933558145 851 17234175
SGTC_2607 solasodine 47.35 µM -0.821130348874308 0.177250599381772 no 2785 0.205786012398255 888 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_187 1488-2104 32.728 µM -0.82123059048808 0.177221763757261 no 2786 0.205757467557967 861 2852859
SGTC_2610 ononetin 44.17 µM -0.822734290366292 0.176789563233202 no 2787 0.205329555455857 898 259632
SGTC_1218 1348-1416 30.7 µM -0.823716813530905 0.176507522005978 no 2788 0.205050241840524 863 6787668
SGTC_2596 sinensetin 100 µM -0.823775153958084 0.176490783870118 no 2789 0.205033663815403 892 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2664 lyso-paf C-16 73.48 µM -0.82516807710254 0.176091446019647 no 2790 0.204638087187422 882 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_961 1252-1571 372 µM -0.825336846243498 0.176043100388786 no 2791 0.204590189251845 890 6813498
SGTC_188 3229-0966 278.469 µM -0.825450180473082 0.176010639366977 no 2792 0.204558027900023 875 5722370
SGTC_936 3005-4620 401 µM -0.826752769857348 0.175637825773865 no 2793 0.204188602429247 875 777207
SGTC_2558 carylophyllene oxide 100 µM -0.8278289138214 0.175330200775505 no 2794 0.203883698753217 896 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2735 sertaconazole 140 nM -0.830157877817202 0.174665616918608 no 2795 0.203224763564568 922 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3191 9110352 49.47 µM -0.830742589890246 0.174499017326789 no 2796 0.203059530463586 870 17122424
SGTC_1377 2944-0135 198 µM -0.83151612032975 0.174278773631272 no 2797 0.202841062697764 874 1894137
SGTC_1628 st004252 77.7 µM -0.834801009902339 0.173345451311306 no 2798 0.201914878579523 869 692968
SGTC_1301 naphtanilide LB 4.81 µM -0.836154992230152 0.172961677665511 no 2799 0.201533857347699 874 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1743 st037606 46.3785 µM -0.837518772989721 0.172575674422674 no 2800 0.201150514577019 865 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3003 9075612 71.4286 µM -0.83861987824217 0.17226441972396 no 2801 0.200841326089227 903 6501993
SGTC_1950 st077106 7.18 µM -0.839944418133562 0.171890480584232 no 2802 0.200469775656451 866 13831864
SGTC_1864 st057645 30.4 µM -0.840464933948439 0.171743672482295 no 2803 0.200323877358988 890 688666
SGTC_585 0kpi-0023 191 µM -0.841124102431729 0.171557873262133 no 2804 0.200139206903031 856 64601
SGTC_3002 9075603 71.4286 µM -0.842099607013829 0.171283144451635 no 2805 0.199866100614291 877 20105405
SGTC_1931 st074438 57.1 µM -0.844366659411803 0.170645767468741 no 2806 0.199232273574044 898 2787313
SGTC_2484 5809818 12.04 µM -0.84537090798728 0.170363910998868 no 2807 0.198951891091903 876 2870548
SGTC_248 streptozotocin 5.23457 mM -0.845511233480952 0.170324550435978 no 2808 0.19891273167829 890 5300 DNA alkylating agent.
SGTC_1102 cgs 12066b 26.1 µM -0.845513741774416 0.170323846925852 no 2809 0.198912031752938 868 6438352 A 5-HT1B full agonist.
SGTC_2788 5282734 71.43 µM -0.847052280373708 0.169892678200688 no 2810 0.198482990851922 892 743706
SGTC_3094 9117742 49.47 µM -0.847433234755251 0.16978602558277 no 2811 0.198376843212004 899 17149698
SGTC_2335 9018011 154.17 µM -0.847830359809426 0.169674891514963 no 2812 0.198266226314021 877 6458208
SGTC_3192 9110362 49.47 µM -0.849511452901099 0.169204960410215 no 2813 0.197798380029154 914 16649480
SGTC_2148 5546263 113.568 µM -0.84980821402604 0.169122090956135 no 2814 0.197715861070275 905 792097
SGTC_420 mitomycin C 81.9 mM -0.851446607715316 0.168665044774706 no 2815 0.197260655316474 863 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1728 st035614 33.7865 µM -0.851952709784881 0.168524023219866 no 2816 0.197120169901277 892 15945546
SGTC_2028 5153890 36.43 µM -0.852050968620427 0.168496652920579 no 2817 0.197092901922488 900 2830968 YPR165W RHO1
SGTC_657 3534-0529 86.7 µM -0.852309126205576 0.168424755955314 no 2818 0.197021271044126 908 1049549
SGTC_1154 4088-0362 150 µM -0.852640281908424 0.168332557880505 no 2819 0.196929408481908 884 6618304
SGTC_197 4544-0043 41.561 µM -0.85333794885929 0.168138424539726 no 2820 0.196735960608729 894 896523
SGTC_2903 5923464 63.88 µM -0.85403096600846 0.167945727733126 no 2821 0.196543916010001 895 2876576
SGTC_2776 terbinafine 19.92 µM -0.855777247295392 0.167460796348454 no 2822 0.196060501374557 868 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2594 a-mangostin 100 µM -0.856064961712848 0.167380986504424 no 2823 0.195980924034521 899 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1724 st037281 8.293 µM -0.856230553093817 0.167335063799282 no 2824 0.195935132915313 875 574124 YDL195W SEC31
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.856550376453239 0.167246391628957 no 2825 0.195846710279937 911 279621
SGTC_969 1313-0238 134 µM -0.856824089895627 0.167170527654952 no 2826 0.195771055041265 898 5212874
SGTC_2086 5274770 176.623 µM -0.856889687178282 0.167152349635108 no 2827 0.195752926385547 886 689278
SGTC_3342 9147791 14.508 µM -0.85898596306643 0.166572110353779 no 2828 0.195174130187888 878 1838168
SGTC_2383 9036125 200 µM -0.860102397476268 0.166263617788683 no 2829 0.194866299881567 891 79580
SGTC_2304 7443016 91.4 µM -0.860319268481619 0.166203734935785 no 2830 0.194806537113522 902 939854
SGTC_1326 1431-2094 10.8 µM -0.860511260956486 0.166150733219474 no 2831 0.194753639383333 902 616278
SGTC_2388 9080168 200 µM -0.860523772702166 0.166147279588128 no 2832 0.194750192452829 893 15943073
SGTC_2658 polymyxin b sulfate 77.05 µM -0.863875975412171 0.165223638110046 no 2833 0.193828012879722 895 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2018 5133068 143 µM -0.86432937435793 0.165098967492389 no 2834 0.193703489042509 902 785362
SGTC_974 1326-0144 138 µM -0.866515148169472 0.164498802337017 no 2835 0.193103861461809 897 5411856
SGTC_698 k064-0052 127 µM -0.867654845397587 0.164186428266175 no 2836 0.192791656102476 934 5088751
SGTC_776 4476-4378 112 µM -0.867853490399951 0.164132022018927 no 2837 0.192737271441737 919 2892008
SGTC_1156 4092-0367 4.88 µM -0.867893525026788 0.164121058478443 no 2838 0.192726311970839 892 1357585
SGTC_1277 0873-0036 22 µM -0.869120169421681 0.163785370389968 no 2839 0.192390702912552 897 5965735
SGTC_463 ikarugamyin 104 µM -0.870198942937768 0.163490517766905 no 2840 0.192095846758305 919 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1939 st074455 53.6 µM -0.872888876202409 0.162756802071519 no 2841 0.191361825005049 887 1644229
SGTC_1713 st033146 12.748 µM -0.872977394073489 0.162732694076932 no 2842 0.191337699735933 901 674619
SGTC_3074 9116018 49.47 µM -0.874391409444049 0.162347899472374 no 2843 0.19095256703725 939 17027303
SGTC_1435 4092-0789 56.7 µM -0.874793476161855 0.162238593687101 no 2844 0.190843143771494 883 2248285
SGTC_2340 7987427 183.45 µM -0.874977993839069 0.162188446788412 no 2845 0.190792939796227 878 2239331
SGTC_2943 9068529 45.32 µM -0.875008224577842 0.162180231856092 no 2846 0.19078471532305 906 3270634
SGTC_1325 1431-0015 227 µM -0.876643588682021 0.161736240085174 no 2847 0.190340127912978 887 1103340
SGTC_714 4296-0578 26.1 µM -0.876898353726336 0.161667144250344 no 2848 0.190270925237575 895 1589775
SGTC_1460 k062-0059 9.15 µM -0.876983585601036 0.161644032472431 no 2849 0.190247776871118 875 1373085
SGTC_1729 st035615 45.989 µM -0.878204790051947 0.161313122844003 no 2850 0.189916296505549 884 17385451
SGTC_578 3460-0051 92 µM -0.878206624953439 0.16131262597364 no 2851 0.189915798712259 922 2876744
SGTC_2241 6772625 37.8075 µM -0.879077309486552 0.161076967169023 no 2852 0.189679679850855 888 2285411
SGTC_1518 st038567 90.8 µM -0.879911635792171 0.160851359941945 no 2853 0.189453590387589 913 77966
SGTC_2088 5278280 127.392 µM -0.880184744180092 0.160777554506299 no 2854 0.189379618302058 914 791502
SGTC_914 3820-6779 408 µM -0.880731506227932 0.160629862736756 no 2855 0.189231579871859 895 2893481
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.881322509064471 0.16047032030107 no 2856 0.189071643191941 902 688798
SGTC_3178 9107506 49.47 µM -0.881737663764866 0.160358310360115 no 2857 0.188959344182464 888 8897194
SGTC_1436 4092-1007 8.32 µM -0.884405198787627 0.159639820825571 no 2858 0.188238758782139 869 2881121
SGTC_2956 9076196 2.52 µM -0.886190333616478 0.159160180595149 no 2859 0.187757485820773 913 16423868
SGTC_681 1642-0006 26.6 µM -0.887851357425509 0.158714735896178 no 2860 0.187310356484454 932 4446530
SGTC_1520 flindersine 88 µM -0.889253656952341 0.158339311416123 no 2861 0.186933385825073 900 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_337 1315-0038 354 µM -0.890198772920968 0.158086613327512 no 2862 0.186679581720313 890 1626437
SGTC_2244 6635614 200 µM -0.893190131696928 0.157288551868082 no 2863 0.185877680931457 908 836499
SGTC_379 3970-0972 5.9 µM -0.893795063875794 0.157127485188228 no 2864 0.185715775355107 904 2898042 YBL034C STU1
SGTC_108 0509-0257 621.132 µM -0.894093050126887 0.15704818452067 no 2865 0.185636053734354 896 536624
SGTC_1285 0929-0069 65.5 µM -0.894196539468111 0.157020649900283 no 2866 0.185608371727399 897 1206237
SGTC_2110 5483698 200 µM -0.894754896790079 0.156872146809889 no 2867 0.185459062847685 886 2848765 YHR062C RPP1
SGTC_1826 st055655 41.6 µM -0.894883172427424 0.156838043133316 no 2868 0.185424771527041 898 676168
SGTC_868 0527-0199 213 µM -0.89591022811757 0.156565163496383 no 2869 0.185150355509488 899 2849450
SGTC_1700 st030840 7.9285 µM -0.896989090935839 0.156278855989236 no 2870 0.184862369102642 902 5499307
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.897777278201606 0.156069905822059 no 2871 0.184652150305323 895 2346 DNA damaging agent; causes G2/M arrest.
SGTC_3121 9125696 49.47 µM -0.899038341824644 0.155735978198749 no 2872 0.184316119127569 934 1235365
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.900276919429129 0.155408463790585 no 2873 0.183986450353498 895 688761
SGTC_2676 harmalol 100 µM -0.900933478758568 0.15523503566745 no 2874 0.183811844762773 879 5459187 A monoamine oxidase inhibitor
SGTC_245 methotrexate 289.6 µM -0.906453831664807 0.153781905725836 no 2875 0.182347845498051 885 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3091 9116372 49.47 µM -0.906877729955108 0.153670695865519 no 2876 0.182235729549411 920 17169793
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.907283130742956 0.153564388655474 no 2877 0.182128546277653 903 688788
SGTC_1617 st002906 78 µM -0.907612140637261 0.153478149042152 no 2878 0.182041588848012 916 5150859
SGTC_2235 salicylic acid 500 µM -0.908221539900923 0.153318498906063 no 2879 0.181880592991629 905 338 A COX inhibitor and kinase inhibitor.
SGTC_340 k038-0059 454 µM -0.908629135829444 0.153211778542122 no 2880 0.181772960832392 895 23733424
SGTC_184 1494-0393 24.714 µM -0.911400553551874 0.152487447014972 no 2881 0.181042181031491 907 3090647
SGTC_950 1165-0508 94.1 µM -0.91158567855961 0.15243914425644 no 2882 0.180993432116987 911 6148369
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.913743441722299 0.151876890368158 no 2883 0.180425835760565 934 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1835 st008666 49.2 µM -0.914683010436584 0.151632495668336 no 2884 0.180179032993246 892 690455
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.915393463842248 0.151447870654825 no 2885 0.179992554233953 902 66535 A nucleotide analog.
SGTC_555 4296-0685 37 µM -0.915486505732281 0.151423703000085 no 2886 0.179968141714182 909 2908540 YHR072W ERG7
SGTC_1160 4092-0570 10.5 µM -0.918888575727232 0.150541775642712 no 2887 0.179076928010974 912 4994975
SGTC_1208 2323-2347 50.3 µM -0.920869876649101 0.150029737521819 no 2888 0.178559183713877 911 5412760
SGTC_1816 st051957 91.6 µM -0.92241137282712 0.14963216455959 no 2889 0.178157019901442 939 674121
SGTC_1804 st050076 49.1 µM -0.927711755979407 0.148270491634001 no 2890 0.176778554352064 919 3895976
SGTC_781 4335-2806 94.4 µM -0.927977159943407 0.148202527759885 no 2891 0.17670970871496 960 845254
SGTC_3197 9113331 49.47 µM -0.929628119448367 0.147780223014823 no 2892 0.176281831533377 909 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_304 1310-0298 97 µM -0.929954714945512 0.147696777564312 no 2893 0.176197265911788 910 1550234
SGTC_2184 6075246 200 µM -0.930443283612754 0.147572006741954 no 2894 0.176070808396345 885 2267320
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.932200535048974 0.147123823130865 no 2895 0.175616449510282 916 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.932800827797368 0.146970928955711 no 2896 0.175461406873575 916 676296 Flavone; oxidizing agent.
SGTC_121 0557-0495 61.343 µM -0.932809291117502 0.146968774115579 no 2897 0.175459221601424 925 3104427
SGTC_3305 9127027 53.8275 µM -0.932949342667133 0.146933118763018 no 2898 0.17542306208641 909 41905295
SGTC_2647 atorvastatin 60.16 µM -0.933300525977573 0.146843737450521 no 2899 0.175332411832906 894 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1287 0971-0001 34.6 µM -0.933674029680504 0.146748715302012 no 2900 0.175236032659403 892 4665869
SGTC_2441 5730946 39.09 µM -0.935424298595694 0.146303983448643 no 2901 0.174784839697486 880 1774275
SGTC_2970 9090938 41.86 µM -0.935603627825212 0.146258468235835 no 2902 0.17473865300725 911 17217104
SGTC_719 2810-4230 27.3 µM -0.93796864969039 0.145659096168841 no 2903 0.174130260740455 917 721079
SGTC_2480 5767542 37.17 µM -0.938547751837096 0.145512585232705 no 2904 0.17398149451448 897 2867358
SGTC_947 3447-0010 211 µM -0.938795129885053 0.145450029621524 no 2905 0.173917969919426 920 748350
SGTC_1631 benzylvanillin 81.9 µM -0.938939606332996 0.145413503573356 no 2906 0.173880876410101 888 75506
SGTC_2270 7924575 90.91 µM -0.942845533226529 0.144428358258837 no 2907 0.172879958893678 916 1262135
SGTC_1672 st016598 6.51 µM -0.943667713903881 0.144221563792415 no 2908 0.172669738787227 919 4665860 YNL267W PIK1
SGTC_2287 7945887 168.79 µM -0.946709307822061 0.143458279391354 no 2909 0.171893463089743 884 1245853
SGTC_1319 1306-0155 43.7 µM -0.947236222115029 0.143326328533801 no 2910 0.171759210817301 919 3122360
SGTC_2284 7945075 39.21 µM -0.947715603750074 0.143206352115105 no 2911 0.171637127568887 906 1245402
SGTC_1025 k007-0731 70 µM -0.948394908819118 0.143036456400609 no 2912 0.171464225147232 905 6256118
SGTC_441 propafenone 146 µM -0.949960223301164 0.142645486388791 no 2913 0.171066232129992 918 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1765 st044815 90.4 µM -0.951278540075852 0.142316770268082 no 2914 0.170731498899879 923 645695
SGTC_1911 st060208 74.3 µM -0.951835543166208 0.142178038288394 no 2915 0.17059019655961 927 688783
SGTC_650 1328-0195 38 µM -0.951888032135904 0.142164969654449 no 2916 0.170576884849837 925 2780821
SGTC_2261 9010538 184.68 µM -0.958469975664823 0.14053264666634 no 2917 0.168912912185264 919 6457250
SGTC_2587 piperic acid 92.2 µM -0.963836094347626 0.139211298664479 no 2918 0.16756405370261 911 5370536
SGTC_741 4582-0002 126 µM -0.964959889262137 0.13893565067874 no 2919 0.167282451267059 904 2912688
SGTC_1981 st071826 47 µM -0.965020627694744 0.13892076315582 no 2920 0.167267240021075 895 11838600
SGTC_1221 2958-7315 257 µM -0.965577509299875 0.13878431722002 no 2921 0.167127816951117 932 4562705
SGTC_1833 st055984 71 µM -0.968966641048013 0.137955887735386 no 2922 0.166280916761051 909 676288
SGTC_357 1325-0123 420 µM -0.97368058549651 0.136809243687475 no 2923 0.165107579963164 948 1098503
SGTC_407 eburnamonine 100 µM -0.974706526417471 0.136560554271143 no 2924 0.164852927337414 900 3195
SGTC_1360 1598-0022 39.8 µM -0.976105737843457 0.136221882215537 no 2925 0.164506034123643 920 761525
SGTC_1331 1472-0049 76.2 µM -0.977180070539901 0.135962235806059 no 2926 0.164240006331851 922 24051409
SGTC_252 miconazole 1.30953 nM -0.978868700737358 0.13555481022783 no 2927 0.163822429499315 903 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2606 farnesol 9.78 µM -0.980560408549089 0.135147481683481 no 2928 0.163404783160558 929 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1856 st057054 55.7 µM -0.980596551780504 0.13513878830125 no 2929 0.163395867725205 931 1266018
SGTC_2779 methotrexate 400 µM -0.980771081147081 0.135096814869527 no 2930 0.163352821088172 914 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_586 0957-0265 8.15 µM -0.982213269350175 0.134750318038765 no 2931 0.162997395879641 896 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1669 st015249 58.4 µM -0.983607106961847 0.134416017760472 no 2932 0.162654364702432 948 722793
SGTC_850 0388-0143 75.9 µM -0.985358556246115 0.133996755257283 no 2933 0.162223989614223 926 67273
SGTC_473 2-arachidonoylglycerol 10 µM -0.985624589827308 0.133933150748252 no 2934 0.162158683400237 903 5282280 An endocannabinoid.
SGTC_1781 st038725 66.3 µM -0.987642811938037 0.133451300857334 no 2935 0.161663805685027 937 4270275 YIL048W NEO1
SGTC_1506 4226-2149 212 µM -0.987678391804691 0.133442816884777 no 2936 0.161655090170914 928 991114
SGTC_1637 st007924 17.4 µM -0.990126858269992 0.1328598743183 no 2937 0.161056058520538 897 683336
SGTC_1893 st059353 36.1 µM -0.990929399111337 0.13266918370952 no 2938 0.160860027831093 968 3112488
SGTC_3140 9094243 49.47 µM -0.99495772840518 0.131714866637965 no 2939 0.159878412022117 940 19291112
SGTC_1439 4092-1168 46 µM -0.997761110177972 0.131053543148526 no 2940 0.159197606177875 942 2886240
SGTC_3189 9110682 49.47 µM -1.00252455826879 0.129935103792538 no 2941 0.158045155824685 961 17122418
SGTC_2975 9084847 53.72 µM -1.00329228301123 0.129755465124946 no 2942 0.157859929199299 929 27211724
SGTC_2319 6033012 152.6 µM -1.00565001983337 0.129204857554614 no 2943 0.157291976700644 943 847246
SGTC_1769 st044406 64.4 µM -1.00659470571852 0.128984698075427 no 2944 0.157064789843436 944 670903
SGTC_1704 st028805 70.8 µM -1.00735900863691 0.128806767416354 no 2945 0.156881141184067 934 2876101
SGTC_809 3998-0021 90 µM -1.00864799920559 0.128507074698057 no 2946 0.156571739425448 940 715485
SGTC_1902 st060212 70.5 µM -1.00880420704275 0.128470788990332 no 2947 0.156534271520393 905 688944
SGTC_3205 9113483 49.47 µM -1.00913356272315 0.128394305867689 no 2948 0.156455291838847 931 17018033
SGTC_664 1222-0054 14.9 µM -1.01215303257792 0.127694596436869 no 2949 0.155732444473045 920 6813991
SGTC_2379 9035213 200 µM -1.01234967450861 0.127649120210904 no 2950 0.155685445792415 907 646551
SGTC_2884 9058502 51.95 µM -1.01278532962585 0.127548408913001 no 2951 0.155581354751596 927 6471554
SGTC_1438 4092-1045 4 µM -1.02049951916381 0.125774249723957 no 2952 0.153745808594351 928 1351342
SGTC_2733 amorolfine 100 µM -1.02103020725579 0.12565283462712 no 2953 0.153620063667432 980 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_335 4077-0256 27.6 µM -1.02136841487638 0.125575499440622 no 2954 0.15353996194002 925 3121989
SGTC_2119 5528445 120.635 µM -1.02406340153607 0.124960445470675 no 2955 0.152902664745894 947 791935
SGTC_1170 0310-0127 64.8 µM -1.02468026182456 0.124819961145879 no 2956 0.152757039690565 950 774975
SGTC_1588 farnesol 29.9 µM -1.02520407605377 0.124700753890322 no 2957 0.152633452693271 930 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2425 5628681 7.85 µM -1.02602399027062 0.124514321337008 no 2958 0.15244013805397 939 5714958
SGTC_2290 7904846 200 µM -1.02709280470832 0.124271586414972 no 2959 0.152188383226101 936 2962154
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.02735980364261 0.124211000870045 no 2960 0.152125535849475 934 5355888
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.02770984185936 0.124131603931912 no 2961 0.152043168435244 948 803109
SGTC_527 4476-4215 268 µM -1.02884534648989 0.123874289092034 no 2962 0.151776177020322 905 4418754
SGTC_2653 dihydrofissinolide 100 µM -1.03083202858586 0.12342498883486 no 2963 0.151309797906022 948 6857746
SGTC_3295 9122362 53.5725 µM -1.03262099487209 0.123021381122888 no 2964 0.150890649555333 985 4730473
SGTC_1904 st060225 78 µM -1.03521816404139 0.122437083302487 no 2965 0.15028351891697 925 66595
SGTC_1486 3970-0793 4.53 µM -1.03906528072639 0.121575162253446 no 2966 0.1493871883592 939 2844330
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.04238794769463 0.120834180368247 no 2967 0.148615925995837 942 97141
SGTC_1240 0356-0016 42.1 µM -1.04239293038023 0.120833071580673 no 2968 0.148614771410139 896 4305613
SGTC_1777 st045864 34.765 µM -1.04331073136111 0.12062895719334 no 2969 0.148402201256217 963 4691462
SGTC_642 0335-0876 158 µM -1.04653064820375 0.119914783846004 no 2970 0.14765805120559 938 6812350
SGTC_1668 st014914 51.6 µM -1.05009185475717 0.119128390168439 no 2971 0.146837941625964 942 2839556
SGTC_1068 loratadine 26.9 µM -1.05133718068152 0.118854255547565 no 2972 0.146551878205558 966 3957 A H1 histamine antagonist.
SGTC_2780 5215298 71.43 µM -1.05190993469473 0.118728324433099 no 2973 0.146420436724327 955 2834131
SGTC_486 niguldipine 82 µM -1.05362857527831 0.118351013746904 no 2974 0.146026500579606 926 1236 A calcium channel blocker.
SGTC_2969 9091408 28.7 µM -1.05372260703273 0.118330394482926 no 2975 0.146004967768292 928 4286311
SGTC_3020 9089140 49.47 µM -1.05376403223696 0.118321311578475 no 2976 0.145995482276341 956 17217859
SGTC_2323 6148992 148.28 µM -1.05534658877286 0.117974688722361 no 2977 0.145633420479738 944 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_869 0564-0080 44.1 µM -1.05540424573654 0.11796207385799 no 2978 0.14562024096299 929 6843321
SGTC_525 k781-2675 26.7 µM -1.05555039875605 0.11793010106754 no 2979 0.145586836168753 904 3651118 YDL195W SEC31
SGTC_1363 1636-0063 10.4 µM -1.05640868016585 0.117742465052588 no 2980 0.14539077099843 929 6072185
SGTC_504 lovastatin 124 µM -1.05756460144548 0.11749009355008 no 2981 0.145126993999911 954 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2546 rhodinyl acetate 100 µM -1.05787034535394 0.117423404788154 no 2982 0.145057278254727 924 6708682
SGTC_1374 2889-5571 141 µM -1.05885498445599 0.117208817802353 no 2983 0.144832913995896 923 2853281
SGTC_1949 st076024 69.1 µM -1.05948211510696 0.117072289191551 no 2984 0.144690135085306 949 2921930
SGTC_745 0469-0705 296 µM -1.06253943354755 0.116408313666933 no 2985 0.143995433021632 947 3486736
SGTC_2300 7976697 71.57 µM -1.06269700781552 0.116374164889061 no 2986 0.143959689121988 927 2236109
SGTC_1122 capsaicin 818.572 nM -1.06427168773836 0.116033297763472 no 2987 0.143602819929028 950 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1531 st059297 52.4 µM -1.06690226234503 0.115465445770165 no 2988 0.143007986575568 934 7566702
SGTC_1822 st052468 42 µM -1.06772811836253 0.115287579386614 no 2989 0.142821585428069 942 2873678
SGTC_1643 st009866 20.2 µM -1.06807251205951 0.115213464148264 no 2990 0.142743902043259 918 3156273 YOR207C RET1
SGTC_684 1140-0066 328 µM -1.0691740164612 0.114976642355707 no 2991 0.142495632308359 940 6813534
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.07416398157606 0.113908144261504 no 2992 0.14137459624101 935 5282309
SGTC_640 3381-0960 37.1 µM -1.07464246964053 0.113806058909884 no 2993 0.141267414962822 948 1745025
SGTC_2865 9030313 51.95 µM -1.07843168650694 0.112999932361941 no 2994 0.140420576324528 961 42562754
SGTC_92 0063-0024 660.874 µM -1.07974506339609 0.112721474942765 no 2995 0.14012786042995 970 3594437
SGTC_814 3342-0569 96 µM -1.08095219040702 0.112465976673399 no 2996 0.139859190568963 936 4346283
SGTC_2428 5615643 7.78 µM -1.08099528757819 0.112456862461121 no 2997 0.139849604923499 951 2253075
SGTC_2030 5175110 200 µM -1.08259867020074 0.112118153184317 no 2998 0.139493298910411 971 2831986
SGTC_912 3474-0017 2.18 µM -1.08311561112168 0.11200910673878 no 2999 0.139378555287881 962 3360550
SGTC_1049 3226-0134 66 µM -1.08416749591857 0.11178745038272 no 3000 0.139145270296477 941 5702385
SGTC_2182 6325192 200 µM -1.08474739743972 0.111665386016863 no 3001 0.139016774551542 920 736248
SGTC_2376 9072922 81.32 µM -1.09319390353293 0.109898267794667 no 3002 0.137154336599766 962 17087968
SGTC_1071 trifluoperazine 6.31 µM -1.09412829998923 0.109704019796579 no 3003 0.136949356071461 983 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_911 3456-4043 236 µM -1.09423484145222 0.109681886975564 no 3004 0.136925997148629 943 914281
SGTC_1108 betulinic acid 729.144 nM -1.09622755197467 0.109268513771763 no 3005 0.136489602550682 944 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_122 0236-0016 402.397 µM -1.09901040076654 0.108693106927504 no 3006 0.1358817646404 947 6808838
SGTC_2800 7887935 81.82 µM -1.10131295371398 0.108218660391314 no 3007 0.135380237653295 986 2961002
SGTC_2957 9076800 11.52 µM -1.10634551081041 0.107186883463585 no 3008 0.134288500185493 982 16459615
SGTC_1256 0570-0116 285 µM -1.10772972200766 0.106904339814033 no 3009 0.133989279593742 960 410638
SGTC_759 3486-0358 89.3 µM -1.10940313037437 0.106563483488414 no 3010 0.13362815627739 975 875103
SGTC_1145 3546-0597 10.2 µM -1.11086613728963 0.106266127170131 no 3011 0.133312986596691 948 875334
SGTC_660 4031-1742 102 µM -1.11112429241481 0.10621371937644 no 3012 0.133257426406096 919 6738706
SGTC_2203 7227154 166.4 µM -1.11323387572607 0.105786154651311 no 3013 0.132803998594008 960 896304
SGTC_1664 st014217 9.02 µM -1.1133849921947 0.105755574591099 no 3014 0.132771558881269 941 3982782
SGTC_1526 st051518 75 µM -1.11414324770104 0.105602229823166 no 3015 0.132608868869222 952 673993
SGTC_1916 st067606 49.2 µM -1.11617562177795 0.105192008581002 no 3016 0.132173483689031 913 19590279
SGTC_2990 9074105 71.4286 µM -1.12203817340307 0.10401515472718 no 3017 0.130923104765934 963 6502001
SGTC_2817 7995342 71.43 µM -1.12495872629934 0.103432455847426 no 3018 0.130303262273091 983 18879975
SGTC_3293 9120939 62.045 µM -1.12961986804351 0.102507395035699 no 3019 0.129318217752469 961 934087
SGTC_825 1988-2224 89.6 µM -1.13123780341483 0.102187706414195 no 3020 0.128977507310068 964 1180859
SGTC_2833 9001315 45.46 µM -1.1322931445014 0.101979572263582 no 3021 0.128755605667038 953 2989378
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.13437879476342 0.101569148362437 no 3022 0.128317845030008 959 6708760
SGTC_191 3914-0123 66.505 µM -1.13532863657304 0.101382633266451 no 3023 0.128118824008638 984 3144412
SGTC_2366 9070441 60.58 µM -1.13788949093454 0.10088101610327 no 3024 0.127583315016704 952 6837235
SGTC_893 0958-0369 48.9 µM -1.13936337670975 0.100593134797147 no 3025 0.127275812278357 972 6819948
SGTC_229 benomyl 22.8748 µM -1.13977959498519 0.100511947113973 no 3026 0.127189068412435 954 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1666 st014829 29 µM -1.14009557418974 0.100450344029547 no 3027 0.127123242799118 971 3858230
SGTC_1956 st077085 54 µM -1.14157727525278 0.100161840090723 no 3028 0.126814887189375 967 24208685
SGTC_2516 gossypol 71.55 µM -1.14216347391484 0.100047867744532 no 3029 0.126693037742478 978 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1391 3442-0225 151 µM -1.14538058376851 0.0994240630706534 no 3030 0.126025768886419 963 5227075
SGTC_234 nsc-17383 10.7 µM -1.14704028759777 0.0991033567610188 no 3031 0.125682485340311 944 408974
SGTC_1616 st002734 56.1 µM -1.14837000412303 0.0988469606626718 no 3032 0.125407925564752 954 4026101
SGTC_2822 7994718 71.43 µM -1.15343415877672 0.0978749339193067 no 3033 0.12436611384344 1002 1018011
SGTC_2459 5811157 9.22 µM -1.15344431411245 0.0978729917424604 no 3034 0.124364030759027 960 2870684 YBR192W RIM2
SGTC_2440 5628896 157.78 µM -1.15465888829888 0.097640911821957 no 3035 0.12411507062768 974 5522048
SGTC_1224 0823-0416 294 µM -1.15592286596096 0.0973998206636637 no 3036 0.123856354381679 957 3598164
SGTC_665 3914-0008 307 µM -1.15658458368929 0.0972737788760332 no 3037 0.123721061867292 965 1069549
SGTC_3154 9100113 49.47 µM -1.15790210731174 0.0970231778003063 no 3038 0.123451993736733 967 25237525
SGTC_521 r062-0005 13.8 µM -1.15966033564592 0.0966894906219347 no 3039 0.123093562618035 961 2832033
SGTC_1651 st011928 86.1 µM -1.15980856220887 0.0966613978637608 no 3040 0.123063378635468 979 720198
SGTC_3172 9105863 49.47 µM -1.16122365927888 0.0963935022318699 no 3041 0.122775477804905 995 2348785
SGTC_3008 9078912 71.4286 µM -1.16152956256935 0.0963356626887412 no 3042 0.122713304068907 981 16648731
SGTC_1495 4469-0029 237 µM -1.16307475649063 0.0960438904912799 no 3043 0.122399586523697 964 793680
SGTC_2178 5812956 200 µM -1.16331993470906 0.0959976543559804 no 3044 0.12234986028161 950 5403383
SGTC_2079 5212404 121 µM -1.1635531019278 0.0959536984625892 no 3045 0.122302583226988 968 758462
SGTC_3102 9121669 49.47 µM -1.16426969559908 0.0958187013020372 no 3046 0.122157366749752 987 41905072
SGTC_189 3970-0742 2.116 µM -1.16849539328344 0.0950254735109754 no 3047 0.121303498187531 967 2891807
SGTC_2019 4016004 108 µM -1.16935014427959 0.0948656135811615 no 3048 0.121131293906548 973 45595336
SGTC_195 4234-0266 16.654 µM -1.17293963781983 0.0941964510785371 no 3049 0.120410006352297 968 2303354
SGTC_1999 st074831 12.5 µM -1.17301788940547 0.094181902099354 no 3050 0.120394315922335 968 17112523
SGTC_536 3852-0578 10.6 µM -1.1733156836506 0.0941265496601321 no 3051 0.120334617588616 977 2869208
SGTC_2274 7947094 46.08 µM -1.17391440932431 0.0940153342999116 no 3052 0.120214655129491 972 2971028
SGTC_2869 9037858 32.47 µM -1.17402302546778 0.0939951688715634 no 3053 0.120192901508208 961 27187042
SGTC_3206 9114350 49.47 µM -1.17458039974877 0.0938917382312444 no 3054 0.120081314326004 951 17087243
SGTC_2567 aureobasidin a 60 nM -1.17980348085373 0.0929265823145441 no 3055 0.119039192396976 957 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1465 k213-0056 144 µM -1.17980994388879 0.0929253925924745 no 3056 0.119037906844512 925 24048857 YMR208W ERG12
SGTC_194 1486-1323 56.904 µM -1.18102283721119 0.0927023212589321 no 3057 0.1187968255922 964 5178754
SGTC_1165 k072-0275 30.3 µM -1.18127657496723 0.0926557047830472 no 3058 0.118746434952838 971 6153523 YGL055W OLE1
SGTC_120 rhodamine 6G 52.259 µM -1.18422840674938 0.0921146704239205 no 3059 0.118161330089913 984 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_954 1189-0853 2.85 µM -1.184704373548 0.0920276510008617 no 3060 0.118067176323667 950 2828194
SGTC_1782 st039423 80.636 µM -1.1852243948711 0.0919326468341328 no 3061 0.117964368547675 989 2068169
SGTC_2095 5432005 200 µM -1.18745809807748 0.0915253912567697 no 3062 0.117523487593974 981 783734
SGTC_2528 xanthyletin 44.79 µM -1.18938965914295 0.0911743024508967 no 3063 0.117143184074086 989 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2029 5175081 200 µM -1.1914882102665 0.0907939938484733 no 3064 0.116730991126489 960 1380876
SGTC_3275 9138069 49.47 µM -1.19408431515765 0.0903251468348302 no 3065 0.116222494015938 980 17617007
SGTC_2832 7992762 51.95 µM -1.19600197001053 0.0899799816992266 no 3066 0.115847895149574 965 2985177
SGTC_1568 digitonin 820 nM -1.20533143929914 0.0883147136386314 no 3067 0.114037688641807 985 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1810 st050138 53 µM -1.20813334494456 0.0878190989029724 no 3068 0.113497987721284 989 3444541
SGTC_1335 1486-0900 202 µM -1.2094173731699 0.0875926681623289 no 3069 0.113251268722933 970 X1335
SGTC_2214 7179297 48.276 µM -1.20986631528684 0.0875136027625478 no 3070 0.113165097288216 987 769744
SGTC_3000 9075062 71.4286 µM -1.21040967614722 0.0874179800709281 no 3071 0.113060865395429 930 17057871
SGTC_1109 tnp00067 928.257 nM -1.21097237850643 0.0873190358130192 no 3072 0.112952995491237 977 676295
SGTC_2649 anisomycin 9.56 µM -1.21124080562867 0.0872718656841744 no 3073 0.11290156396522 986 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_313 3474-0040 5.03 µM -1.21157184360054 0.0872137192850772 no 3074 0.11283815901645 977 1043375 YIL048W NEO1
SGTC_1993 st073995 70.8 µM -1.21424149719296 0.0867458549278292 no 3075 0.112327759230083 968 3098394
SGTC_2124 5246320 200 µM -1.21845029102083 0.0860120650381288 no 3076 0.111526451915146 968 579342
SGTC_380 3970-0968 6 µM -1.22169916610776 0.0854488177739008 no 3077 0.110910705879736 977 2891601
SGTC_804 1595-0054 20.9 µM -1.22226461009978 0.0853510714070864 no 3078 0.110803788877324 991 761523 Stimulates phospholipase C.
SGTC_2777 climbazole 1.536 µM -1.22569334952751 0.0847601501159846 no 3079 0.11015704691182 991 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2654 protoveratrine a 100 µM -1.22698646447578 0.0845380885047544 no 3080 0.109913839167399 986 5702278 A heart drug and vasodilator.
SGTC_3167 9103034 49.47 µM -1.22862768560076 0.0842568767933356 no 3081 0.109605715182869 987 5127859
SGTC_1005 4092-0690 4.4 µM -1.23096378347699 0.083857814499855 no 3082 0.109168204969178 991 1529343
SGTC_1550 gossypolone 36.6 µM -1.23223988016504 0.0836404265256699 no 3083 0.108929745059845 986 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1986 st071812 45 µM -1.23453236076149 0.0832509576263413 no 3084 0.108502297907697 999 11838594
SGTC_3223 9129970 49.47 µM -1.23456788267691 0.0832449335635095 no 3085 0.108495684134602 988 17248386
SGTC_2105 5350118 200 µM -1.23530067393667 0.0831207346370006 no 3086 0.108359311509603 978 2133313
SGTC_695 3505-6186 243 µM -1.24273866374282 0.081867964088503 no 3087 0.106982075697722 974 1819379
SGTC_2132 5317594 122.667 µM -1.24420201240214 0.0816231781920641 no 3088 0.106712611653352 992 794577
SGTC_3146 9095609 49.47 µM -1.24534390902227 0.0814325477503088 no 3089 0.106502680949285 990 17173999
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.24717222913966 0.0811280239508395 no 3090 0.106167176636183 964 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_771 0250-0039 27.3 µM -1.2473921218848 0.0810914567283681 no 3091 0.106126876898469 989 3005115
SGTC_173 1273-0061 2.693 µM -1.24807126528715 0.0809785966195808 no 3092 0.106002480081917 952 2847414 YPL266W DIM1
SGTC_1563 conessine 56.1 µM -1.24952059329392 0.0807381437086899 no 3093 0.105737363101626 994 441082 An anti-amoebic, histamine inhibitor.
SGTC_720 r052-1644 49.9 µM -1.25046334517566 0.0805820247216455 no 3094 0.105565168600538 988 1422863 YOR257W CDC31
SGTC_3148 9097893 49.47 µM -1.25153702479749 0.0804045020409195 no 3095 0.105369307117658 949 17174100
SGTC_2830 7992007 71.43 µM -1.25553784548617 0.0797456059510691 no 3096 0.104641789228659 973 1952075
SGTC_1680 diphenhydramine 100 µM -1.26084856846444 0.0788773013666958 no 3097 0.103681705653629 963 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_647 0140-0236 81 µM -1.2611585378601 0.0788268433889902 no 3098 0.103625866792804 1005 990837
SGTC_2897 9048598 12.99 µM -1.261328789927 0.0787991395275369 no 3099 0.103595206336286 996 6467404
SGTC_408 cantharidin 100 µM -1.26270626481476 0.078575264451983 no 3100 0.103347380877165 979 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2508 celastrol 40.54 µM -1.26359435071454 0.0784311834833484 no 3101 0.10318783115543 940 122724 Celastrol is a natural product and antioxidant.
SGTC_472 calcifediol 10 µM -1.26371738079882 0.0784112391783673 no 3102 0.103165742209334 1002 5283731 A vitamin D metabolite.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.2696148784412 0.0774597041485032 no 3103 0.102110923478222 990 2333 A French combination drug.
SGTC_3163 9099914 49.47 µM -1.27011732059968 0.077379044490647 no 3104 0.10202142138225 1019 16268368
SGTC_145 3737-0113 38.366 µM -1.27046019829474 0.0773240371810667 no 3105 0.101960375941754 972 6849351
SGTC_1443 4112-3303 14 µM -1.27644414266295 0.0763688191412317 no 3106 0.100899280168048 992 704433
SGTC_377 3970-0964 33.1 µM -1.28528698801801 0.0749737081046766 no 3107 0.0993460077336477 1002 16481235
SGTC_2135 5326629 150.42 µM -1.28542995318459 0.0749513136493786 no 3108 0.0993210398766233 989 5020077
SGTC_1423 4048-0112 5.59 µM -1.28605145220357 0.0748540196394045 no 3109 0.0992125527808968 983 X1423
SGTC_68 0986-0284 82.829 µM -1.28891035919518 0.0744077060280413 no 3110 0.0987146261147341 955 423278 YIL048W NEO1
SGTC_838 0109-0203 71.4 µM -1.29765045323039 0.0730558578177225 no 3111 0.0972037382744354 982 759422
SGTC_721 1187-1332 279 µM -1.29925540970285 0.0728096715008342 no 3112 0.0969281457406408 1009 25730
SGTC_524 r073-0010 27.8 µM -1.29999470616585 0.0726964837722334 no 3113 0.0968013917856372 1001 2772106
SGTC_614 0462-0418 107 µM -1.30109024212182 0.07252900292906 no 3114 0.0966137837034137 971 5188303
SGTC_554 4483-2211 187 µM -1.30172496246355 0.0724321049178293 no 3115 0.0965052115348471 1007 747107
SGTC_2457 5731572 11.68 µM -1.30403673875407 0.0720800216192115 no 3116 0.0961105281715122 985 2865357
SGTC_1203 3992-3522 103 µM -1.30506328104437 0.0719241006055017 no 3117 0.0959356503499486 1006 5322312
SGTC_752 1896-0090 130 µM -1.30733156064704 0.0715804899681327 no 3118 0.0955500649472619 998 772567
SGTC_392 N-ethylmaleimide 8.33 µM -1.31044704762374 0.0711105948298476 no 3119 0.0950223232776923 980 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1055 3448-0672 86 µM -1.31084457908592 0.0710508077156435 no 3120 0.0949551389952065 985 748378
SGTC_2343 7990716 14.84 µM -1.3136297153886 0.0706330166819881 no 3121 0.0944854218815206 1003 6456862
SGTC_2321 7390090 138.78 µM -1.32341897796847 0.069179525309808 no 3122 0.092848042019624 1013 649046
SGTC_2728 chlorpromazine 9.18 µM -1.32458622424826 0.0690077638399829 no 3123 0.0926542137202584 1033 2726 A thorazine and dopamine antagonist.
SGTC_1354 1498-1681 81 µM -1.32477289392411 0.0689803257201202 no 3124 0.0926232438713179 1007 5754243
SGTC_3268 9137683 49.47 µM -1.32553307845602 0.0688686748934952 no 3125 0.0924972028429969 1047 1953228
SGTC_560 2332-1943 155 µM -1.32838996162492 0.0684503202937368 no 3126 0.0920246569850101 986 21177716
SGTC_3088 9117578 49.47 µM -1.32920494818452 0.0683313359216623 no 3127 0.0918901815192478 1040 678341
SGTC_306 1672-3436 11.6 µM -1.33340254841644 0.0677210314829478 no 3128 0.0911998682787301 1001 6797378
SGTC_3169 9102970 49.47 µM -1.33468992313759 0.06753470157375 no 3129 0.0909889265000694 1035 17027839
SGTC_114 0364-0001 490.298 µM -1.33493716831315 0.0674989616021871 no 3130 0.0909484557972248 1018 4003655
SGTC_484 loperamide 105 µM -1.33739191348118 0.0671449139294977 no 3131 0.090547371325651 996 3955 An opioid-receptor agonist.
SGTC_1745 st081495 74 µM -1.3393923912416 0.0668574485920814 no 3132 0.0902214825535687 972 13842402 YBL026W LSM2
SGTC_1707 st032323 6.317 µM -1.34281917061083 0.0663672397079426 no 3133 0.0896652671479749 985 3132057 YMR211W DML1
SGTC_1462 k081-0014 26.5 µM -1.34739131947603 0.0657175226180231 no 3134 0.0889271174135643 913 3270634
SGTC_1124 fisetin 1.16336 µM -1.34944161692105 0.0654277748644907 no 3135 0.088597580531536 1000 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2786 7743617 45.45 µM -1.34969946824905 0.065391405599791 no 3136 0.0885562014980455 991 583674
SGTC_930 2810-3379 265 µM -1.35325926822581 0.0648909061511525 no 3137 0.0879864084064268 1025 1015764
SGTC_1441 4106-0040 13 µM -1.35589346780014 0.0645224623745996 no 3138 0.0875665330957914 1000 2904180
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.35651693799769 0.0644354963010716 no 3139 0.0874673749339651 975 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3235 9132602 49.47 µM -1.36026558324557 0.06391452715122 no 3140 0.0868729476823134 995 4912240
SGTC_2403 6032726 181.2 µM -1.36378485566277 0.0634284219166846 no 3141 0.0863176440183287 998 2881040
SGTC_1483 3453-0561 55.9 µM -1.3648380568266 0.0632835076341761 no 3142 0.0861519772809196 1003 4546991
SGTC_499 genistein 192 µM -1.36621838615911 0.0630939728922362 no 3143 0.0859352141336894 1025 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_604 1000-0114 314 µM -1.36638731427698 0.0630708075571714 no 3144 0.0859087141792162 1020 1572745
SGTC_2165 5727197 32.143 µM -1.36800030314294 0.062849949742883 no 3145 0.0856559906096088 1003 1361712
SGTC_1073 triclabendazole 3.09 µM -1.37018387079885 0.0625519262608399 no 3146 0.0853147559381367 1011 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1600 coumarin 106 71.1 µM -1.37311149968678 0.062154079938528 no 3147 0.0848588432961918 1001 100336 A hepatotoxic, DNA x-linker.
SGTC_2208 7283366 200 µM -1.3738728726796 0.0620509382668291 no 3148 0.0847405763330804 985 898663
SGTC_1802 st050112 57.9 µM -1.37533612124565 0.0618530899303523 no 3149 0.084513631474821 1012 4662563
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.38198864663882 0.0609597924364091 no 3150 0.0834875935762948 1032 688801
SGTC_3147 9097027 49.47 µM -1.38474339806182 0.0605928520356514 no 3151 0.0830654719570667 1015 25236841
SGTC_2880 9042983 58.44 µM -1.38477855512087 0.0605881802108878 no 3152 0.0830600950924984 1020 6464714
SGTC_2299 7976368 114.88 µM -1.38558869061213 0.0604806038818407 no 3153 0.0829362667633262 1001 2979718
SGTC_347 4534-1311 26.2 µM -1.38984659994129 0.0599176593321514 no 3154 0.0822877320145629 1008 2862016
SGTC_3256 9138902 49.47 µM -1.39013831866431 0.0598792414863055 no 3155 0.0822434396629492 1035 17228773
SGTC_447 ml7 120 µM -1.39287502102551 0.0595197708419555 no 3156 0.0818287935943385 1036 4216 Selective myosin light chain kinase inhibitor.
SGTC_3023 9089636 49.47 µM -1.39388073953755 0.0593880937583439 no 3157 0.0816768106889088 1039 17249241
SGTC_2339 9000433 200 µM -1.40136733426153 0.0584150514406198 no 3158 0.0805521276304835 993 2988954
SGTC_1235 benzylparaben 21.5 µM -1.40861731560006 0.0574847383099681 no 3159 0.0794741779656907 1027 7180
SGTC_1540 guanosine 70.6 µM -1.40863074220364 0.0574830262929101 no 3160 0.0794721918343041 1002 6802 Guanosine is a purine nucleoside
SGTC_132 0417-1715 25.805 µM -1.40984199604005 0.0573287450962469 no 3161 0.0792931715202835 1016 6769098
SGTC_2731 amoxapine 43.43 µM -1.41134260923484 0.0571380593848372 no 3162 0.0790718081993851 1047 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2259 7964009 200 µM -1.41627777469987 0.0565144578483533 no 3163 0.07834709620182 995 313134
SGTC_2370 9071495 200 µM -1.4179356473661 0.0563061787012701 no 3164 0.0781047768722131 1027 21791103
SGTC_827 3253-0474 693 µM -1.42043507271474 0.0559933193384282 no 3165 0.0777405291063345 1011 5402065
SGTC_430 0958-0115 16.4 µM -1.42199102927189 0.055799249862706 no 3166 0.0775144275898743 998 6833180
SGTC_3220 9131269 49.47 µM -1.42208899461616 0.055787048741195 no 3167 0.077500208628874 1012 17722206
SGTC_1446 4239-0190 62 µM -1.43150319006751 0.0546243442193443 no 3168 0.0761430266827453 1030 1340085
SGTC_1358 1509-0022 2.48 µM -1.43274534407358 0.0544723728467827 no 3169 0.0759653129825628 1005 3258434
SGTC_2695 st077686 51.995 µM -1.43430623603408 0.0542818798213518 no 3170 0.075742445758818 1007 2876092
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.43563967392335 0.0541195633495062 no 3171 0.0755524496447242 1016 16486 A toxic proline analog.
SGTC_3351 9150312 21.596 µM -1.43854452227031 0.053767292517418 no 3172 0.0751398072044627 1019 4904905
SGTC_1581 himbacine 57.9 µM -1.44055417684547 0.0535246463022904 no 3173 0.0748553369724451 1041 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1022 4477-0945 21.3 µM -1.45076558481127 0.0523050946276052 no 3174 0.0734225729234692 1006 4648966
SGTC_948 3448-0295 75.3 µM -1.45641693331508 0.051639698053385 no 3175 0.0726386986496234 992 678569
SGTC_1308 1187-1617 41.4 µM -1.45901312790644 0.0513362833995982 no 3176 0.072280747236142 1016 2882570
SGTC_55 0767-0285 6.563 µM -1.46608622290512 0.0505168490841244 no 3177 0.071312399269094 1003 3116166
SGTC_295 k015-0027 31 µM -1.46684307895521 0.0504297862367917 no 3178 0.071209373897403 1023 3887424
SGTC_2940 9060638 45.86 µM -1.46778905962064 0.0503211361100041 no 3179 0.0710807650744974 998 4027022
SGTC_1575 cyproterone acetate 48 µM -1.47350576907429 0.0496685110191576 no 3180 0.0703073547024815 1022 9880 An androgen receptor antagonist and liver toxin.
SGTC_1629 st005085 44.9 µM -1.47823348738541 0.049133907539271 no 3181 0.0696726467582621 991 24207091
SGTC_627 1391-0720 175 µM -1.48013923008609 0.0489197128669744 no 3182 0.0694180470385211 1026 997839
SGTC_2333 9017922 200 µM -1.48318356716821 0.0485790951978482 no 3183 0.0690128229870229 1005 3163164
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.4866211614549 0.048196759939486 no 3184 0.0685574477778077 1046 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_423 5-fluorouracil 457 µM -1.48803029301307 0.048040731234773 no 3185 0.0683714524535385 997 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1016 4226-1401 38 µM -1.48951466719759 0.0478768086298922 no 3186 0.0681759469817819 1016 2901613
SGTC_2683 piperine 63.03 µM -1.49076005183674 0.0477396238594911 no 3187 0.0680122517135484 1031 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_662 k832-1615 104 µM -1.49167899624917 0.0476385999251006 no 3188 0.0678916589463616 1028 5878478
SGTC_2836 9010338 19.48 µM -1.49396552964435 0.0473879733879663 no 3189 0.0675923145528245 1018 2994051
SGTC_2137 5261020 140 µM -1.49943702689564 0.0467925316108389 no 3190 0.0668801469834288 1018 763655
SGTC_3301 9125354 19.7965 µM -1.50434943459668 0.0462630605288136 no 3191 0.0662457083547928 1008 41905162
SGTC_1120 ficusin 1.78878 µM -1.51025671249591 0.0456327424776544 no 3192 0.065488966298731 1028 6199 A DNA cross-linker.
SGTC_260 nsc-65238 3.989 µM -1.51090372719093 0.0455641262774209 no 3193 0.0654064905582218 1025 3246252
SGTC_1042 0350-0096 82 µM -1.51566581639981 0.0450616532734042 no 3194 0.064801937737262 1022 3122515
SGTC_3077 9117319 49.47 µM -1.52299134698168 0.0442974142995387 no 3195 0.0638804351467301 1039 17154678
SGTC_51 1013-0126 23.419 µM -1.52583802003157 0.044003266944917 no 3196 0.0635251047361631 1021 1627850
SGTC_1092 toremifene 6.32 µM -1.53162923359438 0.0434097215013557 no 3197 0.062806977164804 1038 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2499 avocadenofuran 51.48 µM -1.54208639008158 0.0423543439737038 no 3198 0.0615263008868085 1020 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1735 st034310 56.75 µM -1.54437948597393 0.0421257130742709 no 3199 0.0612482133567191 1017 871153
SGTC_341 1486-1430 230 µM -1.54754196394405 0.041812040976107 no 3200 0.0608663068119342 1040 2054753 YPL210C SRP72
SGTC_510 ag-490 170 µM -1.54767465200233 0.0417989216937377 no 3201 0.0608503239554617 1043 5328779
SGTC_1433 4060-0023 7.6 µM -1.55483883735219 0.0410955107678602 no 3202 0.0599922284837014 1030 3840627
SGTC_3334 9142812 21.919 µM -1.55525319700965 0.0410551225698807 no 3203 0.0599428896361433 1021 45283678
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.55588472742336 0.0409936283671498 no 3204 0.0598677528555356 1042 364106
SGTC_1752 st044819 83.042 µM -1.55772453048994 0.0408149063996432 no 3205 0.0596492814460249 1016 441209 YML126C ERG13
SGTC_1614 st002383 48.6 µM -1.56498989512596 0.0401153033002226 no 3206 0.0587926393375276 1028 1947235
SGTC_45 0kpi-0036 14.9 µM -1.56787186851519 0.0398405024172355 no 3207 0.0584555190984605 1029 2795021
SGTC_2089 5281248 129.67 µM -1.56875519213742 0.0397565831059572 no 3208 0.0583524963846753 1019 2737878
SGTC_1932 st074806 40.9 µM -1.57207128219429 0.0394428227598395 no 3209 0.0579670103580192 1017 17251235
SGTC_73 0327-0325 16.231 µM -1.57646678832065 0.0390300385263308 no 3210 0.0574591334443674 959 53298
SGTC_2652 actinonin 100 µM -1.57913744579369 0.038780958072526 no 3211 0.0571522671545046 1044 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_921 1561-0023 372 µM -1.58045418247446 0.0386586292677779 no 3212 0.0570014458215548 1018 24050882
SGTC_1316 1272-0050 65.9 µM -1.58378715091263 0.0383503910969823 no 3213 0.056621082133326 1041 7340392
SGTC_152 4469-0003 551.229 µM -1.58468428256074 0.0382677660689169 no 3214 0.0565190423540133 1025 697280
SGTC_1732 st034308 51.822 µM -1.58495519390067 0.0382428439283571 no 3215 0.0564882573934141 1012 830119
SGTC_2007 4011539 71.82 µM -1.59176906896424 0.0376203508032188 no 3216 0.0557183012586448 1016 45595301
SGTC_2534 helenine 20.12 µM -1.59198463762184 0.0376007929666597 no 3217 0.0556940782011806 1018 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2979 9012552 45.46 µM -1.59724628039526 0.0371259899592528 no 3218 0.0551054100662445 1042 17100905
SGTC_160 3453-0671 289.699 µM -1.59872000225375 0.0369938853514815 no 3219 0.0549414155640754 1041 5322268
SGTC_795 0685-0265 78 µM -1.60175250531578 0.036723260180735 no 3220 0.0546051747265935 1027 302754
SGTC_3355 9151058 44.0485 µM -1.60329914478342 0.0365858604884053 no 3221 0.0544343126119814 1045 17015728
SGTC_138 0850-0259 40.9225 µM -1.60364788703358 0.0365549372534114 no 3222 0.0543958444503796 1019 6813004
SGTC_1365 1672-3266 55.4 µM -1.60631065138627 0.0363195322936304 no 3223 0.0541028356050008 1009 6415873
SGTC_2232 chlorophetanol 41.5365 µM -1.60900331321428 0.0360827475210623 no 3224 0.053807808577851 1053 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_815 1582-0027 36.9 µM -1.61046523549244 0.0359547208040606 no 3225 0.0536481644927897 1037 3128206
SGTC_2835 9006588 71.43 µM -1.61160258420053 0.0358553759230491 no 3226 0.0535242239990093 1000 2345538
SGTC_1448 4255-0083 152 µM -1.62683452253024 0.0345464449060145 no 3227 0.0518861237053331 1051 5399660
SGTC_1163 k060-0048 49.9 µM -1.62684808661559 0.0345452970326097 no 3228 0.051884682931046 1053 6809982
SGTC_3304 9125678 46.087 µM -1.62841226953067 0.0344131365716039 no 3229 0.0517187488671046 1046 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1613 st002381 52.1 µM -1.63128971014996 0.0341711019110817 no 3230 0.051414601781732 1026 551167
SGTC_663 1486-0733 13.9 µM -1.63764314207691 0.0336416402259456 no 3231 0.0507480789228918 1039 722445 YPR165W RHO1
SGTC_1024 4507-0395 26 µM -1.63974631907896 0.0334678669869724 no 3232 0.0505289619070543 1044 4201836
SGTC_2070 5230947 200 µM -1.63982527310668 0.0334613578951286 no 3233 0.0505207508760538 1044 2835538
SGTC_2234 tolnaftate 200 µM -1.64892601441268 0.0327180328978141 no 3234 0.0495813964395845 1066 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.65811609053282 0.0319812813756632 no 3235 0.0486470183790763 1053 165521
SGTC_2332 7982454 138.89 µM -1.66362220777145 0.0315464669255025 no 3236 0.048093975520089 1047 2981748
SGTC_448 monastrol 171 µM -1.6680788181831 0.0311981196880641 no 3237 0.0476500407095052 1051 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1896 st058441 89 µM -1.67280033357883 0.0308325435985688 no 3238 0.0471833045976725 1034 688759
SGTC_2047 4141938 200 µM -1.67839425616242 0.0304040157871118 no 3239 0.0466350790910043 1050 3807862
SGTC_1925 st057770 10.1 µM -1.69398455544942 0.029235680820788 no 3240 0.0451341089529852 1028 5989122
SGTC_2465 5809242 33.21 µM -1.69990269710972 0.0288020526365888 no 3241 0.0445746147625037 1063 2731748
SGTC_898 1000-0849 28.3 µM -1.69997560812021 0.0287967439000374 no 3242 0.0445677568398959 1046 6751807
SGTC_1199 1638-0010 4.46 µM -1.70560431184568 0.0283893600904304 no 3243 0.0440408880189877 1037 3111136
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.71064288588837 0.0280287663377988 no 3244 0.0435735285166436 1049 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2598 perillyl alcohol 100 µM -1.71421910099879 0.0277751496921796 no 3245 0.043244247074834 1050 10819 An apoptosis inducer.
SGTC_3317 9138495 8.753 µM -1.72482809030564 0.0270340117082915 no 3246 0.0422792289207476 1054 17020139
SGTC_1934 st074720 32.6 µM -1.73030561842703 0.0266578613786919 no 3247 0.0417878431343503 1026 17250992
SGTC_2191 5911152 200 µM -1.76049526113608 0.0246623080783258 no 3248 0.0391619351458089 1048 2875902
SGTC_611 3453-1652 23.7 µM -1.76725952467765 0.0242328036247317 no 3249 0.038592387504006 1060 1560575
SGTC_2787 5284540 71.43 µM -1.77189247811368 0.0239422682478085 no 3250 0.0382062036369776 1051 736958
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.78586423812528 0.0230837606656771 no 3251 0.0370606212813928 1066 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2639 lactacystin 53 µM -1.79237716854135 0.0226925131557049 no 3252 0.0365362847645566 1026 3870 A proteasome inhibitor.
SGTC_2236 dapsone 200 µM -1.79300383792753 0.0226551641256935 no 3253 0.0364861551977611 1055 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1848 st056003 16.4 µM -1.80216217448731 0.0221152197073234 no 3254 0.0357599469796603 1042 146492
SGTC_826 1683-5028 118 µM -1.80365068518843 0.0220284965119957 no 3255 0.0356430424931465 1049 722377
SGTC_11 0438-0307 1.3 µM -1.81326130720903 0.0214754486373236 no 3256 0.0348957640337333 1053 4011476
SGTC_2231 micatex 6.853 µM -1.81627917276569 0.0213042240162375 no 3257 0.0346637792188834 1063 20737 An antifungal of unknown mechanism.
SGTC_1638 st008370 60.6 µM -1.82298548389241 0.0209278577180198 no 3258 0.034152794741066 1021 24207134
SGTC_3210 9128157 49.47 µM -1.8456131290497 0.0196992330874938 no 3259 0.0324741994043027 1032 17590849
SGTC_6 0844-0013 19.835 µM -1.85002687177872 0.0194668555195352 no 3260 0.032154838332391 1075 1584900
SGTC_2213 7173844 200 µM -1.85112091959752 0.0194096168510797 no 3261 0.0320760795803863 1059 892728
SGTC_2008 4012253 172 µM -1.85618461123679 0.0191465522873221 no 3262 0.0317136243909667 1023 603940
SGTC_237 nikkomycin 200 µM -1.86137321076224 0.0188801489818916 no 3263 0.0313457454940614 1069 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2293 7624732 200 µM -1.86215486182355 0.0188402904993121 no 3264 0.0312906324019694 1047 894453
SGTC_1892 st058411 7.36 µM -1.86739769596355 0.0185747905898153 no 3265 0.0309230356640282 1064 3934738
SGTC_1128 3448-9350 235 µM -1.87138550627818 0.0183749847171176 no 3266 0.0306458331860749 1043 619386
SGTC_931 2812-0076 566 µM -1.87745039259229 0.0180746194755538 no 3267 0.0302281951683782 1060 3450959
SGTC_3035 9091303 49.47 µM -1.87975606259697 0.0179615337013795 no 3268 0.0300706655377848 1069 25237002
SGTC_177 1327-0068 8.361 µM -1.88127387391799 0.0178874196587914 no 3269 0.0299673365356492 1043 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_3332 9141069 11.198 µM -1.88886775462698 0.0175205189650886 no 3270 0.0294547755773572 1056 17332883
SGTC_2751 anetholtrithion 17.25 µM -1.89387682132586 0.0172820370885633 no 3271 0.0291206808777907 1065 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_828 2074-0507 139 µM -1.92703761561129 0.0157721482254304 no 3272 0.0269874711528468 1047 X828
SGTC_353 1988-1175 58.3 µM -1.93450163580222 0.0154483434981014 no 3273 0.026525740567273 1034 2788357
SGTC_2655 perillic acid 100 µM -1.93654432389093 0.0153607283461552 no 3274 0.0264005347086756 1078 5702197 An apoptosis inducer.
SGTC_2937 9044753 11.33 µM -1.93693213693511 0.0153441425185747 no 3275 0.0263768197177645 1041 6465530 YGL099W LSG1
SGTC_1763 st044482 94.5 µM -1.94493129933317 0.0150054518139774 no 3276 0.0258916236890651 1060 88505
SGTC_3113 9123498 49.47 µM -1.94625203573777 0.0149501534181033 no 3277 0.0258122360288602 1079 8897275
SGTC_1225 1216-0074 20.6 µM -1.94725584915796 0.0149082416457975 no 3278 0.0257520345104824 1066 4241466
SGTC_2417 cerulenin 830 nM -1.94968294596002 0.0148073213632098 no 3279 0.0256069601057342 1056 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2938 9059746 27.26 µM -1.95428632911016 0.0146175229303862 no 3280 0.0253336823453849 1057 6471769
SGTC_1455 4262-0120 131 µM -1.95662581510403 0.0145218703080789 no 3281 0.0251957388138999 1052 1529587
SGTC_1074 carmofur 3.8 µM -2.02049289483113 0.0121108774077471 no 3282 0.0216661432016007 1068 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2704 st078022 71.1 µM -2.0296332938696 0.0117959191906919 no 3283 0.0211969140172035 1070 54697681
SGTC_2092 5303694 80.6725 µM -2.03507938970117 0.0116116577682867 no 3284 0.0209214427154527 1066 1963699
SGTC_620 0109-0052 432 µM -2.05904005736256 0.010830357095077 no 3285 0.0197452006504484 1070 493037
SGTC_733 4069-0007 56.1 µM -2.06818832866187 0.0105443546660337 no 3286 0.0193111586641311 1070 5717425 YNL287W SEC21
SGTC_3041 9091929 49.47 µM -2.08454836826334 0.0100492711611766 no 3287 0.0185551576893549 1067 25236887
SGTC_272 doxorubicin 8.13 µM -2.09319325792091 0.00979594746530539 no 3288 0.0181659531796154 1079 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2498 4'-Methoxychalcone 54.63 µM -2.10006309482128 0.00959863383397984 no 3289 0.0178616456095341 1065 641818 YHR062C RPP1
SGTC_881 0833-0569 170 µM -2.10523106280312 0.00945249899838521 no 3290 0.0176355997821228 1069 5418700
SGTC_2419 paclitaxel 166.5 µM -2.17076858878548 0.00776133490879526 no 3291 0.0149743347429284 1059 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3030 9087619 49.47 µM -2.17624057756471 0.00763299110730862 no 3292 0.0147686381084494 1064 25236973
SGTC_162 k030-0015 37.8 µM -2.18752135659066 0.00737428705415728 no 3293 0.0143522429479011 1077 1809920 YMR134W ERG29
SGTC_3285 9112818 20.8695 µM -2.18764419190894 0.00737151311133833 no 3294 0.0143477650807327 1070 17017947 YPR165W RHO1
SGTC_1126 isoteolin 1.0172 µM -2.19110726062315 0.00729368548205094 no 3295 0.0142220157214797 1074 133323
SGTC_2775 cyproheptadine 69.59 µM -2.19455145633195 0.00721700142652499 no 3296 0.0140978944924509 1076 2913 A selective serotonin reuptake inhibitor.
SGTC_592 k241-0073 46.5 µM -2.20747760948543 0.00693550879156371 no 3297 0.0136403547917903 1083 4230158
SGTC_1056 3448-1962 115 µM -2.20926544562787 0.00689734820508561 no 3298 0.0135780915713176 1061 715507
SGTC_2136 5328288 199.296 µM -2.21284838531909 0.00682142963974889 no 3299 0.013454050083306 1075 262395
SGTC_1850 st056238 17 µM -2.24680163877774 0.00613784977499771 no 3300 0.0123263534968243 1065 5393177
SGTC_1632 st005650 90 µM -2.25323289839575 0.00601543297469581 no 3301 0.0121222340576313 1067 2759605
SGTC_15 0266-0086 27.098 µM -2.26842883229716 0.00573474302686151 no 3302 0.0116515410527662 1088 1712902 YIL048W NEO1
SGTC_40 0327-0103 19.753 µM -2.28631305952472 0.00541933551339623 no 3303 0.0111179752059061 1050 409036
SGTC_2753 fluvastatin 17.09 µM -2.28874076829472 0.00537773093019373 no 3304 0.0110472093931184 1078 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_136 0097-0015 404.482 µM -2.31009269908841 0.00502387386342395 no 3305 0.0104415112806359 1073 4861337
SGTC_2049 5262831 67.185 µM -2.31177160592941 0.0049969498184055 no 3306 0.0103951364698635 1066 763417
SGTC_2661 dactinomycin 12.96 µM -2.31636353602626 0.00492396594268068 no 3307 0.0102692139688429 1078 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2561 acetosyringone 100 µM -2.32982033731158 0.00471552423771572 no 3308 0.0099078244064665 1072 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2006 4011487 200 µM -2.3531482123942 0.00437276757783836 no 3309 0.00930760631388367 1073 45595294
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -2.35683705876711 0.00432065517525161 no 3310 0.00921566615306415 1060 6857784
SGTC_360 0957-0399 1.01 µM -2.36978737711986 0.00414207308693502 no 3311 0.00889915868469443 1079 6752301 YPR165W RHO1
SGTC_1836 st055642 81 µM -2.37511914560474 0.00407048899239795 no 3312 0.00877164317893863 1079 8571
SGTC_885 0865-0106 16.8 µM -2.3862524808329 0.00392457274401709 no 3313 0.00851053046633936 1079 2793380
SGTC_1936 st074407 74.3 µM -2.39716131889967 0.00378616177146005 no 3314 0.00826132381040706 1077 809813
SGTC_1384 3089-0840 101 µM -2.4010625459669 0.00373773576196583 no 3315 0.0081737710256611 1077 1069836
SGTC_1187 1391-0724 117 µM -2.40125567743295 0.00373535291159072 no 3316 0.00816945795516475 1085 6997986
SGTC_2782 7736369 71.43 µM -2.41088193729942 0.00361829695595229 no 3317 0.0079569995028564 1072 2950836 YOL077C BRX1
SGTC_2033 5192550 145 µM -2.41883907481387 0.00352403449346086 no 3318 0.00778506335289611 1073 182073
SGTC_1596 piperlongumine 63 µM -2.42809681565425 0.00341714424350335 no 3319 0.00758914544062453 1080 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2147 5545932 89.7195 µM -2.43087287605678 0.00338566443838729 no 3320 0.00753124917919341 1090 797404
SGTC_1749 st037932 54.2 µM -2.43196591031373 0.00337334139694817 no 3321 0.00750856031117934 1078 594497
SGTC_619 1652-1634 108 µM -2.44812645987125 0.00319579007790021 no 3322 0.00718006222299074 1088 5400454
SGTC_482 fipronil 114 µM -2.45075506891263 0.00316771907056958 no 3323 0.00712784601311232 1091 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2673 kobusone 100 µM -2.45938767678671 0.00307708543641842 no 3324 0.00695871201657968 1091 6710676 An epoxy ketone and protein crosslinker.
SGTC_32 0928-0142 34.1 µM -2.48290159036713 0.00284193740913345 no 3325 0.00651585418536663 1079 2244242
SGTC_1463 k081-0032 34.1 µM -2.48951250459132 0.00277881094937593 no 3326 0.00639592092878694 1040 977755
SGTC_1023 4482-3888 16 µM -2.49774798201277 0.00270194303481799 no 3327 0.00624925066942995 1079 3303168
SGTC_1226 3909-7979 35.4 µM -2.51871489270808 0.00251483438078587 no 3328 0.00588919930370313 1079 6615510
SGTC_273 hydroxyurea 18.1 mM -2.53069548989219 0.00241325709929745 no 3329 0.00569183146793997 1092 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2783 7738165 71.43 µM -2.56512405314532 0.00214168249189464 no 3330 0.00515694613498321 1083 17201110
SGTC_2407 paclitaxel 400 µM -2.58386845803058 0.00200577078356108 no 3331 0.00488495242192947 1077 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3325 9138760 55.175 µM -2.58435722357179 0.00200233401355817 no 3332 0.0048780344348353 1080 43844959
SGTC_2438 5259590 200 µM -2.59443894468142 0.00193262613023339 no 3333 0.00473727199009893 1079 1201127
SGTC_2451 5856223 45.7 µM -2.61405251620651 0.00180329301821156 no 3334 0.00447376411303339 1076 2179896
SGTC_1910 st062352 60.4 µM -2.62855443608099 0.00171278391436242 no 3335 0.00428743150695588 1079 2245730
SGTC_1364 1653-0028 37.6 µM -2.66455909692449 0.00150567160786756 no 3336 0.00385446600402838 1086 5718652
SGTC_1685 st024049 53.0905 µM -2.70629623200095 0.00129432898003291 no 3337 0.00340191616250975 1087 1941139
SGTC_2026 5148700 152 µM -2.71895088438683 0.00123582970283263 no 3338 0.00327446658550431 1092 79838
SGTC_2059 5238311 157 µM -2.72309980430088 0.00121718338680644 no 3339 0.00323362585356263 1081 703021
SGTC_3335 9143315 29.6265 µM -2.74539306236007 0.00112132737753759 no 3340 0.00302192306093113 1083 4899691
SGTC_1253 0550-0034 176 µM -2.75556659692284 0.00107992540147979 no 3341 0.00292952877752341 1084 5969915
SGTC_2154 5570129 200 µM -2.78443021719899 0.000969972667354832 yes 3342 0.00268109290340233 1094 673366
SGTC_799 1310-0557 151 µM -2.80132478542607 0.000910482387677097 yes 3343 0.00254466348345305 1089 5354492
SGTC_1603 st002045 67.8 µM -2.83882076314411 0.000790238242599804 yes 3344 0.00226402917566591 1090 5887985
SGTC_139 0099-0334 718.624 µM -2.9053710342561 0.000612150152566164 yes 3345 0.00183408990115841 1087 97690
SGTC_520 3584-0023 682 µM -2.93246600729504 0.000550902453661703 yes 3346 0.00168140866762233 1084 1340790
SGTC_44 0929-0055 61.211 µM -2.93376509872379 0.000548113367572729 yes 3347 0.00167438771453727 1066 1379590
SGTC_2446 5162541 200 µM -2.95049856932829 0.000513335847915359 yes 3348 0.00158630756902843 1091 1549321
SGTC_170 4197-0004 226 µM -2.96860916045569 0.000478004990433388 yes 3349 0.00149575413104581 1089 218692
SGTC_929 2805-0021 398 µM -2.982972491802 0.000451600746714898 yes 3350 0.00142731824935836 1094 3098024
SGTC_42 0133-0086 60.653 µM -2.99824036018802 0.000425020407215776 yes 3351 0.00135771710447662 1083 162923 Model of phenazepam hydroxylation.
SGTC_365 0121-0052 13.6 µM -3.18681216720858 0.000196519557323379 yes 3352 0.000719250806377332 1081 3101739
SGTC_1242 0402-0103 60.1 µM -3.30993123196437 0.000116157092883475 yes 3353 0.000466594475796673 1091 432868
SGTC_2414 st077232 92.9 µM -4.23329451465953 1.28073485136476e-06 yes 3354 1.15146300397717e-05 1093 729801
SGTC_2811 7967822 32.47 µM -4.42870666150185 4.33834717367942e-07 yes 3355 4.73999272521435e-06 1092 2232244
SGTC_1249 0481-0015 10.2 µM -4.75772660707179 6.32921474929772e-08 yes 3356 9.78927074102906e-07 1092 4227577