SGTCid condition conc unit RKM5|YLR137W.score RKM5|YLR137W.strain.pval RKM5|YLR137W.strain.significant RKM5|YLR137W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_669 0108-0021 26.2 µM 4.67604251073772 1.27631115076016e-07 yes 1 1.46232002391152e-06 50 17201
SGTC_749 1000-0129 128 µM 4.36917787336832 7.33492394874867e-07 yes 2 6.23575778055328e-06 11 708470
SGTC_307 1501-1223 22.3 µM 4.34207963774087 8.51439215345603e-07 yes 3 7.05701757751676e-06 7 2830329
SGTC_1467 k284-1082 293 µM 4.16432556748582 2.21659208844689e-06 yes 4 1.56137129181469e-05 14 3334705
SGTC_753 1322-0200 289 µM 4.13832149170676 2.54173137922807e-06 yes 5 1.7492795815707e-05 13 5403907
SGTC_909 3448-9333 149 µM 4.05750992501536 3.86965112894739e-06 yes 6 2.47993550449424e-05 16 3344074
SGTC_1217 1183-1422 255 µM 3.75124601190984 1.77619266315429e-05 yes 7 8.79789717119045e-05 17 2849664
SGTC_521 r062-0005 13.8 µM 3.71532968835474 2.10863651974316e-05 yes 8 0.00010146945886316 17 2832033
SGTC_1307 1187-1599 12.2 µM 3.59628649715033 3.68405316807546e-05 yes 9 0.000161396141098116 17 1538471
SGTC_2714 st079313 56.9 µM 3.54199022274605 4.72592117885939e-05 yes 10 0.000198560096739404 13 2939799
SGTC_1818 st052136 56.3 µM 3.50312591718632 5.63634427494093e-05 yes 11 0.000229916018100523 74 674169
SGTC_1313 1220-0047 237 µM 3.46829028585163 6.59073555687341e-05 yes 12 0.000261890581845776 57 3528706
SGTC_1499 4480-0877 67.3 µM 3.34825961828115 0.00011178021357345 yes 13 0.000406603964211372 17 2861909
SGTC_907 3448-6986 75.5 µM 3.34332533644861 0.000114193758466432 yes 14 0.000413903936657914 46 590582
SGTC_2343 7990716 14.84 µM 3.25675061781564 0.000165364815734428 yes 15 0.000563476980230277 40 6456862
SGTC_736 0958-0254 92.6 µM 3.25480783614445 0.000166728054914854 yes 16 0.000567345569324204 57 6812352
SGTC_748 act1.228 77.9 µM 3.24493883171733 0.000173816960114556 yes 17 0.000587379275927284 110 4421505 YNR035C ARC35
SGTC_2514 salinomycin 42.74 µM 3.23556492916776 0.000180810433040798 yes 18 0.000607011354764815 90 23682228 A polyether potassium ionophore.
SGTC_3217 9129673 49.47 µM 3.15423099645796 0.000253530257789527 yes 19 0.000804608284448994 80 17248312
SGTC_1852 st056254 31.4 µM 3.14538968176079 0.000262899633245713 yes 20 0.000829328684192309 37 442583
SGTC_2384 9036245 200 µM 3.09535437042448 0.000322291939385116 yes 21 0.000982889397079514 65 6462766
SGTC_2272 7805186 180 µM 3.08932014661455 0.000330243006823423 yes 22 0.0010030756557238 35 2956062 YPR165W RHO1
SGTC_3299 9121982 43.1275 µM 3.07460350108387 0.000350405791499215 yes 23 0.0010539128519452 69 17594604 YPL160W CDC60
SGTC_3250 9135583 49.47 µM 3.06984100925345 0.000357171913900513 yes 24 0.00107086375234129 26 7699353
SGTC_2537 larixol 68.93 µM 3.05234647736502 0.000383082346645564 yes 25 0.00113529923145996 68 6708759
SGTC_6 0844-0013 19.835 µM 3.01823968385721 0.000438684209800346 yes 26 0.00127123864754413 209 1584900
SGTC_3060 1327-0027 12.5 µM 3.01370595832939 0.000446614395473574 yes 27 0.00129038901042137 63 16000455 YPR107C YTH1
SGTC_2123 5259487 200 µM 2.88811291020941 0.000726832823480901 yes 28 0.0019378036233386 64 2173474
SGTC_2103 5378138 10 µM 2.88809691229584 0.000726877082909101 yes 29 0.0019379021867457 67 244142
SGTC_36 0335-0881 14.2 µM 2.8630865319157 0.000799188990372149 yes 30 0.00209767985330631 197 23828853
SGTC_915 methyl methanesulfonate (MMS) 110 mM 2.86230492168941 0.000801552045364594 yes 31 0.00210286036804764 97 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_280 3448-3607 3.04 µM 2.82809986649854 0.000911487347717441 yes 32 0.00234125983516143 42 626179
SGTC_827 3253-0474 693 µM 2.79636669486894 0.00102570158708453 no 33 0.00258403630244472 78 5402065
SGTC_367 0335-0881 7.1 µM 2.72572480483612 0.00132855356694917 no 34 0.00320802339237468 171 23828853
SGTC_1043 0916-0009 19.3 µM 2.7027308528928 0.00144352292097541 no 35 0.0034386204557245 105 3101130
SGTC_2359 9039622 200 µM 2.66500097668843 0.00165198840035741 no 36 0.00384940495888563 106 6463596
SGTC_833 3852-0053 558 µM 2.63193641741907 0.001856838295285 no 37 0.00424498749693041 90 3123681
SGTC_1785 bathophenanthroline 24 µM 2.61859380829021 0.00194584836772875 no 38 0.00441465057930043 148 72812 An iron chelator.
SGTC_3037 9091026 49.47 µM 2.61464940107452 0.00197289447292011 no 39 0.00446595438352051 259 25236398 YIL048W NEO1
SGTC_2021 4019055 173 µM 2.59332305328073 0.00212512744903245 no 40 0.00475267189405151 273 44827708 YER133W GLC7
SGTC_1744 st037937 38.9 µM 2.55051385013348 0.00246328654480342 no 41 0.00537821250413428 127 1016152
SGTC_532 1548-0774 215 µM 2.54320672878742 0.00252564399876309 no 42 0.0054920110432464 105 5932993
SGTC_821 1114-0266 29.2 µM 2.53859419115157 0.00256573762136193 no 43 0.00556494192575498 106 3123235
SGTC_1686 st019653 115.5 µM 2.50894053286535 0.00283752499569143 no 44 0.00605469342117818 84 97252
SGTC_2344 7990960 76.95 µM 2.49576354804431 0.00296642524789196 no 45 0.00628431753376311 112 140813
SGTC_2978 9011784 42.97 µM 2.48194315992862 0.00310726718941379 no 46 0.00653340584000117 172 2994934
SGTC_1810 st050138 53 µM 2.47548714240785 0.0031750999345307 no 47 0.0066527276255327 81 3444541
SGTC_3160 9100216 49.47 µM 2.46592667310971 0.0032780000851595 no 48 0.00683296535323525 60 17191039
SGTC_1489 4065-0444 182 µM 2.44115525885238 0.00355870943563253 no 49 0.00732017951600506 107 2877968
SGTC_771 0250-0039 27.3 µM 2.43319193449235 0.00365342886037438 no 50 0.00748318254341758 102 3005115
SGTC_2487 5918373 44.05 µM 2.42263147312625 0.00378252697157187 no 51 0.00770427452851052 121 2876279
SGTC_479 n-linoleoylglycine 10 µM 2.42121579703435 0.00380014050768931 no 52 0.00773434571114038 88 6433346 An anti-infammatory.
SGTC_1796 st049173 110.4 µM 2.41855102985532 0.00383349453920979 no 53 0.00779122987610356 73 94134
SGTC_2087 5276107 200 µM 2.39596243050155 0.00412693691716861 no 54 0.00828839465795992 114 144405
SGTC_1475 4092-1048 11.7 µM 2.39515431037854 0.00413779773213443 no 55 0.00830668589979805 173 2881759
SGTC_1266 0828-0227 32.9 µM 2.38492555525006 0.00427749538042099 no 56 0.00854128890187379 134 3913820
SGTC_2338 7999974 200 µM 2.34608546395932 0.00484713734247948 no 57 0.00948587836687035 142 315925
SGTC_857 0438-0306 1.35 µM 2.34195578560431 0.0049115155081277 no 58 0.00959149365329248 106 4686136
SGTC_1924 st058459 75.1 µM 2.3295296780493 0.00510984767470532 no 59 0.00991551132753998 108 688683
SGTC_2815 7968870 71.43 µM 2.29617982965426 0.00567782814318859 no 60 0.0108328006675048 177 2977326 YHR190W ERG9
SGTC_2350 9023895 38.85 µM 2.2854975411929 0.00587125611156037 no 61 0.0111418352189613 157 2997209
SGTC_1811 st050069 61.5 µM 2.26605084277302 0.00623843563434123 no 62 0.0117241352415124 84 3877702
SGTC_3226 9131256 49.47 µM 2.26146659874781 0.00632789938550125 no 63 0.0118651893826862 35 17178073
SGTC_2991 9074669 71.4286 µM 2.25988615543861 0.00635900472681628 no 64 0.0119141586897674 213 17333109
SGTC_2096 5468907 200 µM 2.25985621348598 0.00635959533037609 no 65 0.0119150881169425 135 759785
SGTC_1853 st056710 91.2 µM 2.24955445215331 0.0065657017688862 no 66 0.0122386212787967 161 269167
SGTC_2709 st078560 56 µM 2.24807449758321 0.00659579126626923 no 67 0.0122857199710956 136 17250903
SGTC_99 0109-0120 622.8 µM 2.24152640918885 0.00673039088013408 no 68 0.0124959984165117 133 759414
SGTC_746 1095-0025 46.6 µM 2.23906660651938 0.00678157723268519 no 69 0.012575791327717 153 6749286
SGTC_496 calpeptin 138 µM 2.23875724327891 0.00678803909883446 no 70 0.0125858578400161 146 73364 A calpain inhibitor.
SGTC_3230 9131665 49.47 µM 2.23665042155234 0.0068321904664896 no 71 0.0126545983566581 40 15943720
SGTC_32 0928-0142 34.1 µM 2.23027269069754 0.00696739467255315 no 72 0.0128646725169465 101 2244242
SGTC_1787 fluconazole 80 µM 2.22630015522289 0.0070527990350987 no 73 0.0129970415479288 234 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_534 k292-0788 63.4 µM 2.22163378643068 0.00715429881150273 no 74 0.0131540323143435 166 4146317
SGTC_2713 st079149 53.4 µM 2.20806543812673 0.00745678568239592 no 75 0.0136198559281798 188 3103253
SGTC_1101 ebselen 5.29 µM 2.20663513187857 0.00748931965605514 no 76 0.0136697802360795 167 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2270 7924575 90.91 µM 2.19676751863872 0.00771719675506647 no 77 0.0140185269800828 160 1262135
SGTC_654 1124-0271 80.9 µM 2.19513321390305 0.00775552183028427 no 78 0.0140770216502231 195 5403748
SGTC_1380 2291-0730 164 µM 2.18195142028748 0.00807081231612542 no 79 0.0145565591282826 168 2999191
SGTC_1376 2910-0861 41.3 µM 2.18086808578084 0.008097218335415 no 80 0.014596587418717 194 1112859
SGTC_153 4077-0274 519.67 µM 2.17839302786903 0.00815783235542552 no 81 0.0146883942597117 147 3121976
SGTC_873 0591-4978 488 µM 2.14907496132796 0.00890673406335964 no 82 0.0158142291089929 176 3305145
SGTC_1800 st050079 29.0735 µM 2.14298625732292 0.00906960993461289 no 83 0.0160571009446596 387 3645560
SGTC_1897 st060201 15 µM 2.13673183870406 0.00923962864008648 no 84 0.016309904417449 169 611878
SGTC_2372 9071633 200 µM 2.12963003514071 0.00943605840396563 no 85 0.0166010846778536 154 21321366
SGTC_2404 5161160 200 µM 2.12562427871059 0.00954845734900556 no 86 0.0167672781955163 206 2831543
SGTC_1431 4049-0260 9.09 µM 2.11669517601542 0.00980322289819773 no 87 0.0171428632606461 166 3854841
SGTC_2524 avocatin b 10.57 µM 2.11498443283903 0.00985270594109317 no 88 0.0172156370615636 153 6710748
SGTC_1470 k295-0292 231 µM 2.11193954496472 0.00994131873623454 no 89 0.0173458174866254 188 5045612
SGTC_553 k007-0256 45.7 µM 2.10356133189484 0.0101887431910083 no 90 0.0177083649914431 195 6287000
SGTC_1141 3253-0389 52.6 µM 2.09556813143058 0.0104297873529175 no 91 0.0180602593545788 137 5402031
SGTC_847 0342-0274 5.54 µM 2.09494428541602 0.0104488075537113 no 92 0.0180879727475935 180 18097
SGTC_129 0088-0017 176.636 µM 2.09137126399797 0.0105583274678665 no 93 0.018247398033084 243 182446
SGTC_3014 9081533 49.47 µM 2.08938690946151 0.010619582611853 no 94 0.0183364543217049 158 21367265
SGTC_876 0720-0963 56.8 µM 2.0718924092894 0.011173149074557 no 95 0.0191377380145918 184 765861
SGTC_1032 k061-1018 98.7 µM 2.06446612577473 0.0114156167694622 no 96 0.0194867712224616 240 4005393
SGTC_2381 9035592 200 µM 2.06345148779403 0.0114490970544545 no 97 0.0195348762063636 189 4749657
SGTC_1054 3429-0080 167 µM 2.06015399523615 0.0115584950662402 no 98 0.0196919106700116 228 1162877
SGTC_2749 bexarotene 57.39 µM 2.05422010928642 0.0117576460752893 no 99 0.0199771964758944 244 82146 An retinoic acid receptor inhibitor.
SGTC_1935 st074532 41.6 µM 2.05112838240007 0.0118625845975767 no 100 0.0201272229906585 251 2829742
SGTC_464 bw-b 70c 158 µM 2.05000246596743 0.0119010014659687 no 101 0.0201820950864798 244 5353454
SGTC_555 4296-0685 37 µM 2.04618844413419 0.0120319410187597 no 102 0.0203689169230875 196 2908540 YHR072W ERG7
SGTC_2006 4011487 200 µM 2.04584329335478 0.0120438518293481 no 103 0.0203858955001799 299 45595294
SGTC_1439 4092-1168 46 µM 2.04275103106272 0.0121510196054468 no 104 0.0205385451652524 175 2886240
SGTC_543 3844-1095 191 µM 2.03372005122561 0.0124687491402074 no 105 0.0209899146565619 257 4230703
SGTC_1282 0886-0010 32.4 µM 2.02307790226511 0.0128523747460847 no 106 0.0215325582134921 237 2836211 YNL267W PIK1
SGTC_2427 5545055 42.75 µM 2.02294660538086 0.0128571707559861 no 107 0.0215393264003468 222 5372858
SGTC_3062 9077494 49.47 µM 2.02270782193208 0.0128658970004351 no 108 0.0215516399908962 219 16459633
SGTC_2478 5763493 32.33 µM 2.01658417277054 0.0130914399800326 no 109 0.0218694630361016 194 1365576 YLR208W SEC13
SGTC_894 0960-0238 55.9 µM 2.01388007159642 0.0131921186920117 no 110 0.0220110631519271 164 6741907 YDL195W SEC31
SGTC_2297 7971671 152.32 µM 1.99215370275294 0.0140255894042708 no 111 0.0231770980977224 216 909016
SGTC_3209 9113616 49.47 µM 1.99057677643274 0.0140878126626799 no 112 0.0232637177637097 231 16649353
SGTC_313 3474-0040 5.03 µM 1.98844561794056 0.0141722830335391 no 113 0.0233812139209404 311 1043375 YIL048W NEO1
SGTC_1046 2001-0062 216 µM 1.98643435223849 0.0142524012218034 no 114 0.02349255771096 227 739778
SGTC_3194 9111903 49.47 µM 1.97956634736904 0.0145289337205502 no 115 0.0238761387708847 223 17087251
SGTC_1344 1488-0097 29.1 µM 1.97782113952967 0.0145999340120107 no 116 0.0239744439099087 216 747966
SGTC_762 1165-0429 115 µM 1.97739040419212 0.0146175034872985 no 117 0.0239987588998543 228 5967793
SGTC_2305 7443522 69.23 µM 1.96205609743202 0.015254944795555 no 118 0.0248779767521526 224 5415886
SGTC_1369 1866-0067 208 µM 1.95328449626771 0.0156302029157663 no 119 0.0253929467762357 283 3531355
SGTC_647 0140-0236 81 µM 1.95227864994776 0.015673736073191 no 120 0.025452565413131 249 990837
SGTC_65 0798-0905 34.986 µM 1.95133123612887 0.0157148353580845 no 121 0.0255088278029647 373 3602145
SGTC_493 zm226600 134 µM 1.950861272266 0.0157352569063222 no 122 0.0255367753379027 233 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2001 4023502 57.655 µM 1.93018190031682 0.016656664783779 no 123 0.0267921516893377 260 108941 YCR052W RSC6
SGTC_221 trifluoperazine 10.304 µM 1.90407904798209 0.0178853101051894 no 124 0.0284499449923867 466 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2107 5363541 170.161 µM 1.90293716511989 0.0179407776801862 no 125 0.0285243723709746 232 244052
SGTC_2989 9073649 71.4286 µM 1.90188729451934 0.0179919050836568 no 126 0.0285929452864747 339 21367202
SGTC_510 ag-490 170 µM 1.89793611814676 0.0181854375484812 no 127 0.0288522488791739 181 5328779
SGTC_1754 st042065 16.137 µM 1.88242267524393 0.0189625494828402 no 128 0.0298893247826542 459 1126236 YIL048W NEO1
SGTC_312 4092-0653 6.84 µM 1.88087131460132 0.0190417925399353 no 129 0.0299947130878552 376 1148278
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.88063399510534 0.0190539395511325 no 130 0.0300108620133713 250 7104
SGTC_1286 0929-0070 131 µM 1.87621842314871 0.0192811517628312 no 131 0.0303126466570151 282 1420408
SGTC_2849 9019321 12.99 µM 1.87092803030015 0.0195564079241091 no 132 0.030677528601264 277 16489627
SGTC_222 nsc-310342 10.666 µM 1.86895805082005 0.019659754095362 no 133 0.0308143254252614 135 432556
SGTC_1015 4130-4525 82 µM 1.85494366675711 0.0204084219078648 no 134 0.0318021357179577 268 1363237
SGTC_2826 7992541 19.48 µM 1.83820405616029 0.0213342087106593 no 135 0.0330161711670935 269 2985066
SGTC_1875 nocodazole 6 µM 1.83501892074313 0.0215143260763157 no 136 0.0332514430218907 265 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1215 3852-0577 11.2 µM 1.8272888872096 0.0219568059462603 no 137 0.0338281726041483 289 2884876
SGTC_2810 7959871 45.46 µM 1.82687119798867 0.0219809323877818 no 138 0.0338595688525512 341 2974535
SGTC_1861 st057647 17.4 µM 1.82483175163368 0.0220990559656688 no 139 0.0340132113905704 263 688668
SGTC_1851 st056236 18.9 µM 1.82330980277192 0.0221875550919282 no 140 0.0341282412256015 270 5393171
SGTC_111 0083-0039 52.457 µM 1.81970195686409 0.0223985415446267 no 141 0.0344022025817818 137 759313
SGTC_219 mitoxanthrone 164.414 µM 1.8128344305409 0.0228048314962375 no 142 0.0349286809051328 299 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1289 0976-0073 69.1 µM 1.81185196492893 0.0228634598382015 no 143 0.035004536613992 273 3391136
SGTC_1234 0326-0494 15.5 µM 1.81079494813364 0.02292667875689 no 144 0.0350862993112795 245 1547813
SGTC_2170 morpholine 200 µM 1.81018512023352 0.0229632187778678 no 145 0.0351335421559326 235 121171 Reacts with secondary amines.
SGTC_64 000l-0018 272.079 µM 1.80729909870304 0.0231368111463735 no 146 0.0353578282506483 464 6811119
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.80383020495263 0.0233469238099137 no 147 0.0356289645820224 553 16725076
SGTC_1753 st043925 64 µM 1.79817347679623 0.0236929982107281 no 148 0.036074760641871 298 670181
SGTC_3155 9099265 49.47 µM 1.79039774023202 0.0241757437090863 no 149 0.0366949966743867 263 25236499
SGTC_3207 9114163 49.47 µM 1.78741433967413 0.0243631441567353 no 150 0.0369352728344083 351 849233
SGTC_1967 st070177 51.4 µM 1.7852383338915 0.024500596513724 no 151 0.0371113332618313 256 5729214
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.7840784358235 0.0245741296715049 no 152 0.0372054603830243 318 688667
SGTC_2900 5328528 85.29 µM 1.77709572287498 0.0250207311660806 no 153 0.0377762458917239 347 795359
SGTC_3246 9135460 32.98 µM 1.77324722512724 0.0252697691854383 no 154 0.0380938749025328 203 41446951
SGTC_656 4090-1979 187 µM 1.77084401603121 0.025426332802815 no 155 0.0382933220722126 327 22330961
SGTC_501 nsc-95397 161 µM 1.76964876724961 0.0255045025776367 no 156 0.0383928347527259 242 262093
SGTC_2468 5987765 72.9 µM 1.76768829321445 0.025633154131401 no 157 0.0385565140813366 297 26772094
SGTC_2425 5628681 7.85 µM 1.75357063405775 0.0265757253528136 no 158 0.0397520532688652 347 5714958
SGTC_747 3448-8087 38.7 µM 1.73825251417856 0.0276310235065086 no 159 0.0410831647757044 331 5168703
SGTC_1222 0366-0074 1.18 µM 1.73722971413513 0.0277027131208884 no 160 0.0411733160198863 305 286520
SGTC_713 1488-1073 324 µM 1.73525616016933 0.0278414806561015 no 161 0.0413477215578374 266 3312542
SGTC_1078 idebenone 36.1 µM 1.73424236361029 0.0279129891124805 no 162 0.0414375446042498 384 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_3257 9139206 32.98 µM 1.73323941895661 0.0279838826006769 no 163 0.0415265616981403 214 4910041
SGTC_692 k241-0027 77.8 µM 1.72525967727292 0.0285532931190353 no 164 0.0422403426085078 298 3600480
SGTC_2767 sibutramine 71.45 µM 1.72197352497709 0.0287905686431034 no 165 0.0425371572686666 309 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2606 farnesol 9.78 µM 1.71072973238822 0.0296148555289478 no 166 0.0435655081845117 332 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3302 9125395 16.351 µM 1.70728761777772 0.02987108002056 no 167 0.0438843032164318 305 17599668
SGTC_2457 5731572 11.68 µM 1.70621255539983 0.0299514814701616 no 168 0.0439842559684693 261 2865357
SGTC_3006 9075424 71.4286 µM 1.70018551840118 0.0304055599176161 no 169 0.0445480176752465 320 7465181
SGTC_2934 9036370 36.88 µM 1.69823984258559 0.0305533598685487 no 170 0.0447312517727103 371 6462800
SGTC_2917 7979103 53.79 µM 1.6936244050951 0.0309063449423682 no 171 0.04516833874113 382 2980565
SGTC_1264 0783-0040 158 µM 1.68995713115884 0.0311892157152395 no 172 0.045518078166097 304 2855798
SGTC_539 4859-0462 2.54 µM 1.68899974093563 0.0312634143546936 no 173 0.0456097398004732 304 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_37 0566-0070 1.56 µM 1.68831138709034 0.0313168525896357 no 174 0.0456757352446588 368 1626686
SGTC_1034 k072-0165 12.7 µM 1.68569293493309 0.0315208186758468 no 175 0.0459274791925158 365 5835461
SGTC_2523 spermine 47.74 µM 1.68318952092141 0.0317168493476381 no 176 0.0461692043832314 312 1103 A DNA binding polyamine.
SGTC_1784 st039334 36.3 µM 1.66949937634195 0.0328067544718016 no 177 0.0475092269399218 341 3496984
SGTC_2458 5808907 16.39 µM 1.66532800618149 0.0331449201046023 no 178 0.0479236670119103 295 2731747
SGTC_112 phenothiazine 287.218 µM 1.66169798090134 0.0334415318478443 no 179 0.0482866730938325 324 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2876 9059903 25.97 µM 1.64991257711396 0.0344196245811777 no 180 0.0494804089733226 351 6916095
SGTC_1750 st081859 2.357 µM 1.64760777063669 0.0346136264434219 no 181 0.0497165924120338 578 5291695
SGTC_2785 7756463 72.73 µM 1.6396726842304 0.0352884243314881 no 182 0.0505366207141637 345 2201551
SGTC_2217 6934799 96.0675 µM 1.63768546923067 0.0354590956499641 no 183 0.0507436616695328 314 675606
SGTC_3215 9129942 49.47 µM 1.6362412069908 0.0355835598761751 no 184 0.0508945576965945 301 17682944
SGTC_689 0833-0039 98 µM 1.63231537683606 0.0359236924220466 no 185 0.0513065327857523 352 5374726
SGTC_1381 2324-0066 62.1 µM 1.63205852316921 0.0359460386465661 no 186 0.0513335791039365 375 10885928
SGTC_1477 0139-0234 16 µM 1.62787383292755 0.036311712618325 no 187 0.0517758204517077 330 620880
SGTC_360 0957-0399 1.01 µM 1.62761379885511 0.0363345354953682 no 188 0.0518034006807401 385 6752301 YPR165W RHO1
SGTC_2299 7976368 114.88 µM 1.61853234004283 0.0371389984368869 no 189 0.0527739615396835 335 2979718
SGTC_1641 st009299 47.1 µM 1.61422598364481 0.0375255245944396 no 190 0.053239208963244 276 4046054
SGTC_1587 estradiol valerate 56.1 µM 1.61298965906615 0.037637098462539 no 191 0.053373377222185 367 13791 A steroid.
SGTC_3334 9142812 21.919 µM 1.61174134576887 0.0377500289073701 no 192 0.0535091182510449 360 45283678
SGTC_162 k030-0015 37.8 µM 1.61144029492774 0.0377773052545836 no 193 0.0535418952869249 350 1809920 YMR134W ERG29
SGTC_842 0271-0008 11.1 µM 1.61047366084734 0.0378649947272865 no 194 0.0536472455200814 382 1221709
SGTC_158 k038-0087 26.446 µM 1.60710763484458 0.0381716452605235 no 195 0.0540153793874764 504 X158
SGTC_2757 clomiphene 4.22 µM 1.60051822713262 0.0387778140771598 no 196 0.0547418333405032 425 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1906 st060206 94.7 µM 1.59471468590801 0.0393181627875835 no 197 0.0553880262239994 386 5133468
SGTC_3021 9087658 49.47 µM 1.59022703301717 0.0397401807045665 no 198 0.0558918195614007 290 25237042
SGTC_1624 st003710 6.25 µM 1.58822051347722 0.0399300611678168 no 199 0.0561182420222219 439 24207033
SGTC_916 4466-0038 42 nM 1.58772657950522 0.0399769159284411 no 200 0.0561740900012095 502 5722064 YGL116W CDC20
SGTC_997 3996-0078 137 µM 1.58336631880496 0.0403924728296974 no 201 0.0566689975737883 396 735687
SGTC_172 1112-0046 2.638 µM 1.58126036953809 0.040594433942083 no 202 0.0569092585149865 335 2802135 YIL048W NEO1
SGTC_2680 butyl paraben 22.24 µM 1.57685240024556 0.0410198128105724 no 203 0.0574147456191189 315 7184 An antifungal and steroid mimetic.
SGTC_1318 1280-3875 124 µM 1.57327587795538 0.0413676055721339 no 204 0.0578274761509997 418 373245
SGTC_1174 0739-0097 51.1 µM 1.57290180553583 0.0414041192489695 no 205 0.0578707784893589 405 728447
SGTC_3331 9141060 1.957 µM 1.57250305178039 0.0414430708586981 no 206 0.0579169659840642 357 4906567 YPR165W RHO1
SGTC_1155 4088-0394 48.2 µM 1.57155903793784 0.0415354036824506 no 207 0.0580264262426611 392 2326248
SGTC_2761 levamisole 97.89 µM 1.56603358387653 0.0420791894054152 no 208 0.0586703775406417 361 26879 An alkaline phosphatase inhibitor.
SGTC_3165 9101544 49.47 µM 1.56573994373479 0.0421082483934292 no 209 0.0587047555055259 400 5002184
SGTC_2116 5511452 16.8835 µM 1.5564371156075 0.0430373063092244 no 210 0.0598020925799448 405 870744
SGTC_3170 9103054 49.47 µM 1.55082837253178 0.0436053981965758 no 211 0.0604714096478522 354 16432970
SGTC_455 paf C-16 10 µM 1.5507465585478 0.0436137294424528 no 212 0.0604812160825089 374 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1793 st048256 72.231 µM 1.54605797761142 0.0440933251593296 no 213 0.0610452831725717 344 672022
SGTC_1934 st074720 32.6 µM 1.53727521426805 0.0450031533151894 no 214 0.0621129642025426 466 17250992
SGTC_2683 piperine 63.03 µM 1.53486493891494 0.0452554647307495 no 215 0.0624085036819974 353 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_677 0929-0063 136 µM 1.53383798617904 0.0453633129299799 no 216 0.0625347576513829 324 1539583
SGTC_1267 0828-0272 9.49 µM 1.53211498474086 0.0455447228472801 no 217 0.0627470313031523 447 745334
SGTC_774 k060-0086 136 µM 1.52925058658269 0.045847597701098 no 218 0.0631011671440522 464 5911235
SGTC_3313 9133968 57.047 µM 1.52658368519276 0.0461310427103785 no 219 0.0634322832292811 414 1494643
SGTC_896 0964-0007 44.5 µM 1.52543535246358 0.046253523109989 no 220 0.0635752733272218 389 6756758
SGTC_783 0848-0141 92.7 µM 1.51927078738321 0.0469155016311697 no 221 0.0643471748531569 378 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_83 0170-0301 39.027 µM 1.51867343239767 0.046980050066115 no 222 0.0644223585870717 261 3089716
SGTC_557 1315-0110 16.2 µM 1.51272760916005 0.0476264277583419 no 223 0.0651744317562469 420 6833801
SGTC_231 b-estradiol 524 µM 1.51056261426248 0.0478635485378697 no 224 0.0654499625866826 336 450 A steroid.
SGTC_2480 5767542 37.17 µM 1.50025592244502 0.0490053757842659 no 225 0.0667740611708415 391 2867358
SGTC_2909 7941780 10.49 µM 1.49944537830611 0.0490960871555298 no 226 0.0668790644219747 425 1243215
SGTC_1619 st003326 88.7 µM 1.49627692821799 0.0494519691498686 no 227 0.0672907524240147 380 2849032
SGTC_1204 4049-0315 18.3 µM 1.48968209162986 0.0501993071403458 no 228 0.0681539227806305 426 588402
SGTC_1546 5-methoxyflavanone 78.7 µM 1.48701514056104 0.0505040754556356 no 229 0.0685054060817089 437 147795
SGTC_1129 3453-1384 223 µM 1.48421331495039 0.0508258426191516 no 230 0.0688761692625674 473 1084452
SGTC_2930 9013230 14.89 µM 1.48319103113031 0.0509436493248345 no 231 0.0690118317230689 467 2995857
SGTC_1131 3454-3128 32.3 µM 1.48310207337127 0.0509539109773701 no 232 0.0690236466208504 490 710982
SGTC_2702 st077768 96.8 µM 1.48198667195884 0.0510827169371013 no 233 0.069171920670851 404 6484119
SGTC_1184 1269-1718 139 µM 1.47993687315852 0.0513201021723773 no 234 0.0694450470761065 442 5403821
SGTC_2696 st077691 74.316 µM 1.47661714572642 0.0517064172043003 no 235 0.0698891465210839 404 757133
SGTC_1569 carminic acid 40.6 µM 1.4765609297088 0.0517129788836527 no 236 0.069896685642114 436 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1849 st056239 19.2 µM 1.46809073177741 0.0527092292489346 no 237 0.0710397894011925 461 5393181
SGTC_2419 paclitaxel 166.5 µM 1.45876275308873 0.0538239265285058 no 238 0.0723152087625165 522 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_79 0052-0007 94.094 µM 1.45499113250071 0.054279902716048 no 239 0.0728358582107221 446 2801472
SGTC_315 k915-0449 187 µM 1.45417525967337 0.0543789399267554 no 240 0.0729488611528095 523 20970215 YNL149C PGA2
SGTC_3168 9103419 49.47 µM 1.45092283192012 0.0547751672351333 no 241 0.073400674699873 310 16649256
SGTC_1143 3454-2408 5.08 µM 1.44726548354713 0.0552234463903797 no 242 0.0739112911984312 369 X1143
SGTC_1679 SEC14.276 6.7 µM 1.44603863704979 0.0553744676650394 no 243 0.0740831825802683 530 1005053 YMR079W SEC14
SGTC_1972 st070201 17.4 µM 1.44585029783795 0.0553976805282777 no 244 0.0741095974849543 444 2829099
SGTC_2368 9071271 200 µM 1.44351416059358 0.0556862492920593 no 245 0.0744378431925242 456 27209959
SGTC_1895 st058434 18.3 µM 1.44322195925114 0.055722426456916 no 246 0.0744789777624759 453 5393175
SGTC_1330 1469-0054 61.8 µM 1.44278359305566 0.0557767349316387 no 247 0.0745407211937225 449 7102664
SGTC_1995 st072814 61.1 µM 1.43689742335619 0.0565100154157059 no 248 0.0753735710912459 421 5769371
SGTC_811 0416-0114 265 µM 1.43200007571223 0.0571258831530613 no 249 0.0760718998246145 451 6612453
SGTC_215 1287-0124 461.5 µM 1.42812440179687 0.0576170049615837 no 250 0.0766280275322286 359 5560863
SGTC_1429 4049-0205 9.46 µM 1.42440949262056 0.0580908658092428 no 251 0.0771639839610089 475 22774478
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.42345211187583 0.0582134809153172 no 252 0.0773025674851086 393 6857784
SGTC_2551 apiole 73.87 µM 1.42204368364796 0.0583942327203687 no 253 0.0775067849418958 306 10659 A possible DNA adduct former.
SGTC_1572 epiandrosterone 68.9 µM 1.4205903673586 0.0585812070365607 no 254 0.0777179402316488 500 441302 A steroid.
SGTC_3057 9095946 49.47 µM 1.41957203153389 0.0587124993899096 no 255 0.0778661563153054 454 24540043
SGTC_1146 3579-1023 7 µM 1.41320647790631 0.0595384409048668 no 256 0.078797511200994 531 X1146
SGTC_993 3909-8757 62.7 µM 1.41000855821592 0.0599567990202515 no 257 0.0792685779388193 427 4288324 YLR208W SEC13
SGTC_1023 4482-3888 16 µM 1.40820514915641 0.0601937377503618 no 258 0.0795351659966558 448 3303168
SGTC_1312 1218-2183 165 µM 1.40810375677097 0.060207080800168 no 259 0.0795501743956834 482 6744073
SGTC_2706 st078239 82.5 µM 1.40759322229219 0.0602743013742367 no 260 0.0796257777738766 461 15434492
SGTC_2408 sulbentine 18.36 µM 1.40676280913411 0.0603837649020461 no 261 0.0797488670444022 492 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_881 0833-0569 170 µM 1.40539000215553 0.0605650668860364 no 262 0.0799526690428066 490 5418700
SGTC_2367 9070478 135.38 µM 1.40288706670642 0.0608967168566559 no 263 0.0803252590766338 501 572802
SGTC_413 propylparaben 100 µM 1.40235040006286 0.0609680120765882 no 264 0.0804053184838291 458 7175 A pharmaceutical preservative.
SGTC_1903 st060211 78.3 µM 1.39778920031514 0.0615765963503595 no 265 0.0810881891955259 493 688960
SGTC_1292 0kpi-0043 232 µM 1.39716278137058 0.0616605463638253 no 266 0.0811823130294691 473 3333905
SGTC_417 st075190 100 µM 1.39633132106562 0.0617721131480653 no 267 0.0813073730629749 498 222757
SGTC_71 0417-1750 47.813 µM 1.39602835897939 0.0618128042744001 no 268 0.0813529777304107 513 6811472
SGTC_2354 9060492 162 µM 1.39459073382846 0.0620061783509023 no 269 0.0815696454672764 539 6471895
SGTC_1765 st044815 90.4 µM 1.39323760945217 0.0621886172201659 no 270 0.0817739751395548 472 645695
SGTC_82 0054-0107 293.755 µM 1.39320820962565 0.0621925857787224 no 271 0.0817784189632692 441 3104697
SGTC_1596 piperlongumine 63 µM 1.39162652971111 0.0624063814258658 no 272 0.0820177604381028 525 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_316 k060-0003 58.6 µM 1.38804312247971 0.0628928702581998 no 273 0.082561957218834 463 6152314
SGTC_174 3553-0389 74.3 µM 1.3839786564347 0.0634482390221558 no 274 0.0831824951091998 442 738071
SGTC_1734 st037168 69.4 µM 1.38310876952179 0.0635675948048314 no 275 0.0833157585744923 487 708907
SGTC_1035 k081-0041 55.2 µM 1.37865011037937 0.0641821050431805 no 276 0.0840013292286391 526 731709
SGTC_3088 9117578 49.47 µM 1.37631034545449 0.064506423004917 no 277 0.0843627856649514 463 678341
SGTC_132 0417-1715 25.805 µM 1.37595783793158 0.0645553947074729 no 278 0.0844173434772667 518 6769098
SGTC_311 1315-0136 58 µM 1.37429353220441 0.064786996622082 no 279 0.0846752867221194 501 6759207
SGTC_2102 5377816 72.7585 µM 1.36971985621385 0.0654267846085145 no 280 0.0853871839700391 518 1379702
SGTC_2868 9035608 32.47 µM 1.36212679749214 0.0664997454737901 no 281 0.0865789363152695 522 6462614
SGTC_967 1306-0166 352 µM 1.35965881194327 0.0668514097596306 no 282 0.0869689588815357 515 4437607
SGTC_2316 5844804 197.44 µM 1.35668033794 0.0672777277043912 no 283 0.0874414012891005 622 776813
SGTC_1712 st032288 53.4 µM 1.35611187351244 0.0673593320567148 no 284 0.0875317877980595 685 2883011
SGTC_701 4424-0219 185 µM 1.35291263290174 0.0678200179598488 no 285 0.0880417715428197 567 2911779
SGTC_1799 st045822 46.1415 µM 1.35206692525598 0.0679422043483359 no 286 0.0881769533939973 488 3674992
SGTC_1854 st056233 32.9 µM 1.35078504964897 0.0681277315367108 no 287 0.0883821492721145 491 5393174
SGTC_548 1436-0017 110 µM 1.3493030513227 0.0683427098329834 no 288 0.0886198229780221 606 9677137
SGTC_1172 0370-0043 85 µM 1.34103269417985 0.0695520297064138 no 289 0.0899549189311388 490 376585
SGTC_2644 guaiazulene 100 µM 1.33783582750291 0.0700238775945597 no 290 0.0904749799668311 485 3515 A coloring agent.
SGTC_2440 5628896 157.78 µM 1.33709386125095 0.0701337409019524 no 291 0.0905960003684155 498 5522048
SGTC_1091 telmisartan 47.6 µM 1.33279595469352 0.0707727442758942 no 292 0.0912993868147721 529 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_637 1181-0519 7.26 µM 1.33060188781285 0.0711006734205808 no 293 0.0916600205059556 645 6252091 YGR060W ERG25
SGTC_1050 3232-1156 69.3 µM 1.32970332588997 0.0712353103846232 no 294 0.0918080193015457 530 700529
SGTC_3080 9117754 49.47 µM 1.32928050911556 0.0712987312589214 no 295 0.0918777210930803 561 9550191
SGTC_2281 7943571 200 µM 1.32853621723542 0.0714104774445262 no 296 0.0920005136049427 540 1244024
SGTC_1308 1187-1617 41.4 µM 1.32588832590026 0.0718091153990246 no 297 0.0924383452051342 562 2882570
SGTC_1247 0448-0043 5.84 µM 1.3233358215115 0.0721950064172147 no 298 0.0928618620836755 570 3089013 YGL099W LSG1
SGTC_3329 9141233 27.5565 µM 1.32062543662995 0.0726065038172968 no 299 0.0933131435462275 504 4909101 YNL103W MET4
SGTC_1424 4048-1941 275 µM 1.31942100054825 0.0727899397995616 no 300 0.0935142023893875 564 X1424
SGTC_3042 9091578 49.47 µM 1.31573663285229 0.0733532732462075 no 301 0.0941312271262538 474 25236497
SGTC_3309 9129340 25.759 µM 1.31430468066227 0.0735731139581657 no 302 0.0943718463802738 564 17158987
SGTC_1991 st073000 8.92 µM 1.31224506681915 0.0738901994583253 no 303 0.0947187302093262 597 4301969 YIL048W NEO1
SGTC_1643 st009866 20.2 µM 1.31064406932988 0.0741373997715283 no 304 0.0949890215078614 497 3156273 YOR207C RET1
SGTC_1714 st033236 13.627 µM 1.30699649196036 0.0747029586927287 no 305 0.0956069514509777 565 2916566
SGTC_2075 5212009 200 µM 1.30504151856383 0.0750074304936524 no 306 0.0959393552933954 474 780898
SGTC_2386 9075165 157.42 µM 1.30215164895795 0.0754592374438036 no 307 0.0964322750250025 515 16452277
SGTC_2751 anetholtrithion 17.25 µM 1.2999542250997 0.0758041721552272 no 308 0.0968083291992278 550 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1973 st070275 50.2 µM 1.29772254403266 0.0761557121076164 no 309 0.0971913469967858 494 17118334
SGTC_2808 7946468 45.46 µM 1.29537417213852 0.0765269719749553 no 310 0.0975955916843425 602 2970879
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.29186363322822 0.0770845268051895 no 311 0.0982021869074082 607 23847180
SGTC_2492 derrusnin 100 µM 1.28713034057041 0.077841163420519 no 312 0.0990244309233456 492 1715307 Part of coumarin class of compounds.
SGTC_2871 9038510 12.99 µM 1.285557202958 0.0780938800476794 no 313 0.0992988204612651 588 4945164
SGTC_3076 9116187 49.47 µM 1.28460536356949 0.0782470901874644 no 314 0.0994651117247404 512 27241210
SGTC_2857 9024691 58.44 µM 1.28325227742319 0.0784652780925019 no 315 0.0997018530771011 522 16478292
SGTC_681 1642-0006 26.6 µM 1.28321671010349 0.0784710196105941 no 316 0.099708081625564 500 4446530
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.28283723173959 0.078532297411535 no 317 0.0997745535686212 634 5024745
SGTC_568 1193-0097 7.48 µM 1.28023157869135 0.0789540357592801 no 318 0.100231851471924 587 3646150
SGTC_1740 st038286 13.222 µM 1.2801712139665 0.0789638263930011 no 319 0.1002424637174 565 716786
SGTC_1971 st069429 63.5 µM 1.27860664124887 0.0792179074101162 no 320 0.100517805056075 521 1246522 YGL099W LSG1
SGTC_621 3584-0052 32.1 µM 1.2783674619248 0.0792568037621405 no 321 0.100559945606846 585 2273927
SGTC_445 e6 berbamine 66 µM 1.27627505039515 0.0795976973137127 no 322 0.100929153288274 690 6610268 A calcium/calmodulin antagonist.
SGTC_1735 st034310 56.75 µM 1.27553925579028 0.0797178355008688 no 323 0.101059219411276 566 871153
SGTC_651 3253-0966 34.4 µM 1.27341684670767 0.0800651441252431 no 324 0.10143508120827 587 781462
SGTC_2453 5731132 22.18 µM 1.27026698361512 0.0805826911217269 no 325 0.101994772329157 603 1362040
SGTC_1226 3909-7979 35.4 µM 1.26888513153155 0.08081053599878 no 326 0.102241018024828 624 6615510
SGTC_1195 1502-0147 41.1 µM 1.26641895617695 0.0812183762721886 no 327 0.102681563889081 596 817940
SGTC_1524 corynanthine 62.1 µM 1.2661508170259 0.0812628128442869 no 328 0.102729546027611 531 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3322 9139058 2.11 µM 1.26515774726405 0.0814275461762584 no 329 0.102907392742286 576 4908926 YPR165W RHO1
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.26208846465241 0.0819382800195383 no 330 0.103458477796362 661 551469
SGTC_1412 3909-8563 178 µM 1.26117119947527 0.0820913820427235 no 331 0.103623586353632 630 23767530
SGTC_961 1252-1571 372 µM 1.2610934078668 0.0821043762567334 no 332 0.103637597703254 584 6813498
SGTC_2334 9017922 200 µM 1.26063856211589 0.082180384146094 no 333 0.103719549260574 565 3163164
SGTC_2463 5473429 200 µM 1.2594196688189 0.0823843310078638 no 334 0.103939394405032 555 5399405
SGTC_324 1315-0088 19.6 µM 1.25844203171701 0.0825481857947035 no 335 0.10411596955894 495 6787421
SGTC_1432 4049-0298 68.4 µM 1.25605274390626 0.0829496695338198 no 336 0.104548423887123 553 741646
SGTC_1938 st074717 56.4 µM 1.25590140413402 0.0829751492767677 no 337 0.104575859714244 514 17250979
SGTC_760 0568-0725 82.9 µM 1.25357743249859 0.083367155540267 no 338 0.104997819073763 605 3916171
SGTC_1994 st072947 40.9 µM 1.25273845060601 0.083509016023897 no 339 0.105150453882058 591 5286565 YDL195W SEC31
SGTC_3139 9095020 49.47 µM 1.24836552295345 0.084251357076002 no 340 0.105948614447801 445 25236292
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.24738446084026 0.0844185787304089 no 341 0.106128280752073 474 1241132 A phosphatase inhibitor.
SGTC_409 arachidonic acid 100 µM 1.24629064780853 0.0846053122015074 no 342 0.106328855024866 598 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1084 voriconazole 435 nM 1.24602278935951 0.0846510876245341 no 343 0.106378014364446 582 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_898 1000-0849 28.3 µM 1.24505607705197 0.0848164475311033 no 344 0.106555568968365 595 6751807
SGTC_2893 9048488 25.97 µM 1.24339219761893 0.085101627586832 no 345 0.106861672027775 561 6467338
SGTC_964 1287-0107 19.4 µM 1.24169051538683 0.0853940294929086 no 346 0.107175385358729 638 51516812 YPR165W RHO1
SGTC_2253 7938677 135.83 µM 1.23957703225695 0.0857582385343724 no 347 0.107565940093245 576 2301972
SGTC_921 1561-0023 372 µM 1.23843437002097 0.0859556331143095 no 348 0.107777521546416 594 24050882
SGTC_2181 6316240 54.2555 µM 1.23760284797801 0.0860994919078507 no 349 0.107931678960879 537 12779990
SGTC_1632 st005650 90 µM 1.23665616641131 0.0862634932420506 no 350 0.108107379235755 584 2759605
SGTC_1311 1190-0148 100 µM 1.23665062847557 0.0862644533105141 no 351 0.108108407659694 701 1961333
SGTC_200 k038-0079 37.545 µM 1.23589325010182 0.0863958293510941 no 352 0.108249123183019 559 3436683
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.23506088864967 0.0865403845680396 no 353 0.108403922023651 595 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_282 k297-0036 65.7 µM 1.23495826323498 0.086558219914092 no 354 0.108423018861226 540 5061378
SGTC_2432 5630864 12.22 µM 1.23412170258602 0.0867037089045595 no 355 0.108578778807854 587 5714970
SGTC_484 loperamide 105 µM 1.23329406479589 0.0868478258567163 no 356 0.108733035726879 487 3955 An opioid-receptor agonist.
SGTC_2356 9061756 188.97 µM 1.22669284396756 0.0880037120231047 no 357 0.109969029171139 558 20104043
SGTC_1375 2910-0797 186 µM 1.22318485964077 0.0886226154217629 no 358 0.110629941378896 607 742508
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.22288284914392 0.0886760494405088 no 359 0.110686973654072 536 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_820 1582-0060 59.9 µM 1.22151875004651 0.0889176953126104 no 360 0.110944835405889 620 3848840
SGTC_998 3996-0085 177 µM 1.22109260789466 0.0889932854609743 no 361 0.111025479104596 670 715391
SGTC_3312 9133330 71.43 µM 1.21726173360188 0.0896749643837642 no 362 0.111752324365191 645 17617324
SGTC_1486 3970-0793 4.53 µM 1.21495051691764 0.0900881035406036 no 363 0.112192482424203 626 2844330
SGTC_398 bronopol 33.3 µM 1.21464746683373 0.0901423796432436 no 364 0.112250288348018 611 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1178 0988-0033 191 µM 1.21454562407634 0.0901606250773736 no 365 0.112269719336039 627 5392207
SGTC_2722 naftopidil 47.16 µM 1.21454411069352 0.0901608962251118 no 366 0.112270008098541 644 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_709 3807-1509 243 µM 1.21334408075893 0.0903760923047143 no 367 0.112499148092109 587 1886677 YPL242C IQG1
SGTC_399 oxolinic acid 75 µM 1.21268287496715 0.0904948262814664 no 368 0.112625544839921 585 4628 A DNA gyrase inhibitor.
SGTC_888 0916-0002 6.97 µM 1.21019852567959 0.0909419806962589 no 369 0.113101361851075 628 2802138 YIL048W NEO1
SGTC_740 k014-0057 261 µM 1.208282935478 0.0912878826219856 no 370 0.113469225010132 689 4012779
SGTC_2413 inermin 26.06 µM 1.20645797802534 0.09161832520763 no 371 0.113820476257732 634 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2159 5658611 73.75 µM 1.20409702340317 0.0920471340098038 no 372 0.114276040144047 601 793844
SGTC_2959 9079155 11 µM 1.20336046370942 0.0921812154425932 no 373 0.114418430221552 543 16189457
SGTC_1177 0983-0204 23.6 µM 1.19437312401858 0.0938289083113601 no 374 0.116166022552461 677 766818
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.19424465956454 0.0938526169010674 no 375 0.116191139098818 625 5377381
SGTC_2333 9017922 200 µM 1.19181824438391 0.094301251615766 no 376 0.116666260218693 636 3163164
SGTC_2764 methyldopa 94.69 µM 1.19072136785168 0.0945045781420852 no 377 0.116881493294804 663 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2314 7727897 200 µM 1.18668960614176 0.0952547179303319 no 378 0.117675038166466 605 900724
SGTC_1098 clofazimine 15.1 µM 1.18583588831237 0.0954141195268582 no 379 0.117843557849305 687 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_63 0099-0242 26.702 µM 1.18512298530889 0.095547379310276 no 380 0.117984412160039 692 3898502 YLR359W ADE13
SGTC_2271 7849410 118.62 µM 1.18383793283517 0.0957879343289683 no 381 0.118238611648813 631 972430
SGTC_768 0384-0033 77.3 µM 1.18128897859988 0.0962664028042123 no 382 0.118743972060633 671 3965305 YMR134W ERG29
SGTC_2222 6885208 172.143 µM 1.17661883089184 0.0971475976782104 no 383 0.119673839135503 602 609514
SGTC_1609 st001574 46.4 µM 1.17140854829239 0.0981376788133409 no 384 0.12071729893182 655 3960012
SGTC_2569 tetrandrine 100 µM 1.1707346308458 0.0982662775986683 no 385 0.120852730267005 565 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_252 miconazole 1.30953 nM 1.17035438588957 0.0983388914358847 no 386 0.120929191963245 629 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_299 1273-0059 1.44 µM 1.17012602226563 0.098382519993878 no 387 0.120975128903885 611 2848077
SGTC_1435 4092-0789 56.7 µM 1.16834195178121 0.0987238522345974 no 388 0.121334429832577 660 2248285
SGTC_2109 5483026 200 µM 1.1664382476784 0.0990890279970223 no 389 0.121718651057854 663 759335
SGTC_258 haloperidol 50.781 µM 1.16257176574789 0.0998337503425133 no 390 0.122501645849327 635 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2207 7258803 200 µM 1.16231244251376 0.0998838444470546 no 391 0.122554287146911 604 3666799
SGTC_2915 7971052 15.16 µM 1.16135379643349 0.10006918783649 no 392 0.12274902519988 482 5741558
SGTC_1186 1319-0216 26 µM 1.15957371753308 0.100414011804533 no 393 0.123111203421396 693 4565136
SGTC_2896 9052656 71.43 µM 1.15932496821623 0.10046226668023 no 394 0.12316187401366 747 6469436
SGTC_1998 st075797 76.8 µM 1.15866933189894 0.10058953462414 no 395 0.123295498097999 726 24208315
SGTC_2576 guaiol 23.12 µM 1.15839421851519 0.100642972896533 no 396 0.123351598717093 682 227829
SGTC_1390 3413-2614 145 µM 1.15577132415205 0.101153486371881 no 397 0.123887352663158 676 3421432
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.1505909684183 0.102167317023857 no 398 0.124950275158983 738 688761
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.14938171988388 0.102405035657478 no 399 0.12519930720581 721 4174840
SGTC_3143 9086658 49.47 µM 1.14907906268474 0.102464596031095 no 400 0.125261690469604 732 25236626
SGTC_2848 9016370 25.97 µM 1.14528168457475 0.103214029390015 no 401 0.126046245242323 732 7894410
SGTC_617 3770-0098 35 µM 1.14454430695727 0.103360015218163 no 402 0.12619898701297 628 5962639
SGTC_1857 st056007 79.3 µM 1.14078770098836 0.104106074454953 no 403 0.126979139977721 635 619834
SGTC_218 alverine citrate 93.75 µM 1.13677654055451 0.104906989685609 no 404 0.127815856366011 643 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_535 2293-4129 48.2 µM 1.13569227747486 0.105124250239994 no 405 0.128042686858836 753 396118 YIL048W NEO1
SGTC_2275 7947463 200 µM 1.13547663752212 0.105167498154606 no 406 0.12808783258283 636 1225414
SGTC_2754 granisetron 64.02 µM 1.13450458291764 0.105362609499183 no 407 0.128291476225329 677 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_666 0272-0154 136 µM 1.13389254131003 0.105485593099492 no 408 0.128419813088261 704 6870312
SGTC_1976 st070609 63.5 µM 1.13378833969247 0.105506541704234 no 409 0.128441671636035 706 682556
SGTC_1449 4112-4002 201 µM 1.13203964390767 0.105858547043349 no 410 0.128808883868038 645 2059539
SGTC_1568 digitonin 820 nM 1.13144511029639 0.105978417376622 no 411 0.128933896941367 719 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1936 st074407 74.3 µM 1.12607215820101 0.107066166929093 no 412 0.130067488842737 713 809813
SGTC_346 4513-0042 7.16 µM 1.12348128034996 0.107593556061386 no 413 0.1306165732861 697 2827372
SGTC_3264 9137442 49.47 µM 1.12046406570095 0.108210084887287 no 414 0.131258028654996 650 17015726
SGTC_1274 0865-0114 173 µM 1.11735243044278 0.108848566591525 no 415 0.131921832975569 688 870624
SGTC_1988 st071872 53.4 µM 1.11642744250037 0.109038887655855 no 416 0.132119606114872 704 16414116
SGTC_2206 7254556 146.969 µM 1.1155450352571 0.109220670324274 no 417 0.132308465455515 643 4398905
SGTC_1395 3486-0190 4.35 µM 1.11376104295942 0.109588851340252 no 418 0.132690856895457 729 6748079
SGTC_1980 st071811 45.7 µM 1.10955891226811 0.110459608421072 no 419 0.133594572460505 691 4974850
SGTC_843 0310-0051 143 µM 1.1095136382081 0.11046901695255 no 420 0.133604332147557 697 2065037
SGTC_3218 9131285 49.47 µM 1.10881462035901 0.110614354764219 no 421 0.133755080998865 773 17156417
SGTC_1299 1079-1439 3.74 µM 1.10779963752702 0.110825631011967 no 422 0.133974178339227 658 323161
SGTC_1262 0737-0114 49.6 µM 1.10670879946809 0.111053019264621 no 423 0.134209924837304 779 765919
SGTC_947 3447-0010 211 µM 1.10568417789148 0.111266908648699 no 424 0.134431620326648 695 748350
SGTC_261 5-fluorouridine 15.376 µM 1.10535489143432 0.111335709656753 no 425 0.134502920788816 708 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2077 5212015 200 µM 1.10263958781753 0.111904205440883 no 426 0.135091855680419 655 780900
SGTC_1130 3454-2858 15.9 µM 1.10004857411825 0.112448611588181 no 427 0.13565547925168 687 715628 YIL048W NEO1
SGTC_3337 9144342 33.5465 µM 1.09557154486818 0.113393748783743 no 428 0.136633159983273 723 17682949
SGTC_1701 st028638 40.4 µM 1.09387040777821 0.113754353879508 no 429 0.13700590950316 727 3490878
SGTC_3081 9117243 49.47 µM 1.09344382246436 0.113844908989119 no 430 0.137099490833832 692 45595589
SGTC_960 1222-0186 7.7 µM 1.09280915239691 0.113979731178334 no 431 0.137238801158512 738 3126296
SGTC_351 caspofungin 25 nM 1.09152920386647 0.114251975036616 no 432 0.137520044384722 839 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3064 1327-0027 10 µM 1.09097246414806 0.114370537458132 no 433 0.137642499568546 544 16000455 YPR107C YTH1
SGTC_1211 1056-0033 32.3 µM 1.09077294995662 0.114413047002263 no 434 0.13768640092439 745 6741922
SGTC_2301 7769476 200 µM 1.08668863770044 0.115285745205254 no 435 0.138587218582311 662 977820
SGTC_634 1611-4317 11.2 µM 1.08341219219957 0.115989238318329 no 436 0.13931275318753 785 2843522
SGTC_1512 0259-0544 12.2 µM 1.08248191337313 0.116189534954419 no 437 0.139519223919395 784 18476
SGTC_1699 st031318 29.054 µM 1.07488885403643 0.117833564232721 no 438 0.141212246373652 737 5340658
SGTC_2781 5567276 71.43 µM 1.07385890006029 0.118057828696862 no 439 0.141442963236465 696 2853274
SGTC_846 0335-0850 148 µM 1.07373117819547 0.118085660165055 no 440 0.141471591616722 712 6819598
SGTC_2114 5491910 81.25 µM 1.07092426086067 0.118698478588821 no 441 0.14210174312086 736 2849228
SGTC_2100 5377183 190 µM 1.07070552578434 0.118746327978317 no 442 0.142150928701281 791 2844202
SGTC_379 3970-0972 5.9 µM 1.07030998236629 0.118832889671281 no 443 0.142239901314283 724 2898042 YBL034C STU1
SGTC_1012 4112-3522 18 µM 1.0699336164985 0.118915295873499 no 444 0.142324595153098 738 3112398
SGTC_2793 7325131 81.82 µM 1.06970544627683 0.118965273931705 no 445 0.142375957044697 703 4176441
SGTC_426 0988-0037 14.6 µM 1.0679704965315 0.119345779900447 no 446 0.142766910263115 801 5383008
SGTC_117 lucigenin 22.078 µM 1.06766994241701 0.119411784052618 no 447 0.142834710743212 765 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2441 5730946 39.09 µM 1.06746843572573 0.119456050997762 no 448 0.142880179802023 745 1774275
SGTC_1448 4255-0083 152 µM 1.06660999690412 0.119644762366082 no 449 0.143073992175165 759 5399660
SGTC_1742 st038235 28.8875 µM 1.06539203731301 0.119912868143304 no 450 0.143349279305226 735 564103 YBR002C RER2
SGTC_2950 9072895 21.46 µM 1.06453704667765 0.120101327489049 no 451 0.143542740558144 733 17332245
SGTC_319 1348-1596 45.5 µM 1.06380669499752 0.120262478806695 no 452 0.143708138899778 781 5380505
SGTC_2953 9074162 66.49 µM 1.05824362294042 0.121494964975462 no 453 0.144972194040708 678 16451992
SGTC_1111 tnp00062 510.699 nM 1.05786364642286 0.121579470693719 no 454 0.145058805503836 775 676306
SGTC_1949 st076024 69.1 µM 1.05699645351831 0.121772486685022 no 455 0.145256603000623 712 2921930
SGTC_2093 5331342 194.4 µM 1.05622026845845 0.121945429052915 no 456 0.145433796406822 771 33839
SGTC_1736 st036774 51 µM 1.05416196184563 0.122404876966117 no 457 0.145904385939335 777 1272247
SGTC_2616 abietic acid 100 µM 1.05148385459927 0.12300449132979 no 458 0.146518210425292 798 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_699 0375-0592 111 µM 1.05110606598122 0.123089241691549 no 459 0.146604939202725 792 762578
SGTC_1618 st003135 44.5 µM 1.05048517213002 0.123228617416335 no 460 0.146747552376615 736 1270615
SGTC_2393 9031399 185.94 µM 1.04895678423511 0.123572174779698 no 461 0.147099004398341 761 1526623 YDL150W RPC53
SGTC_515 4092-1064 102 µM 1.04827914674236 0.123724711379214 no 462 0.147255007224488 817 717353
SGTC_640 3381-0960 37.1 µM 1.04740897010532 0.123920781921936 no 463 0.147455498174097 797 1745025
SGTC_970 1315-0089 19.5 µM 1.04619847408955 0.124193895660799 no 464 0.147734703638217 716 6811083 YLR033W RSC58
SGTC_2097 5376186 200 µM 1.04019637486486 0.125554316443484 no 465 0.14912433769625 765 742755
SGTC_1342 1486-1464 234 µM 1.03933702738363 0.125749941765233 no 466 0.149324009978014 786 3253938
SGTC_474 dl-dihydrosphingosine 5 µM 1.03906846285942 0.125811122460042 no 467 0.149386448441845 752 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2967 9089538 49.85 µM 1.03736582881628 0.126199476292875 no 468 0.149782698639217 782 728216
SGTC_2250 alverine citrate 130 µM 1.03322535908028 0.127147360231518 no 469 0.150749224019089 820 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_985 1493-0307 8.71 µM 1.03250597807401 0.127312553005921 no 470 0.150917574306411 730 3278274
SGTC_1817 st052116 64.4 µM 1.03232218562371 0.127354781534588 no 471 0.150960605667698 758 4361398
SGTC_248 streptozotocin 5.23457 mM 1.03153711622421 0.127535270363887 no 472 0.151144506045706 811 5300 DNA alkylating agent.
SGTC_2260 7964312 200 µM 1.02968573911601 0.127961609233751 no 473 0.151578776081203 719 231951
SGTC_2885 9057732 51.95 µM 1.02942951102552 0.128020691870951 no 474 0.151638943743785 739 6471414
SGTC_2014 4013930 200 µM 1.02585776129946 0.128846261414135 no 475 0.152479317423032 837 64556
SGTC_850 0388-0143 75.9 µM 1.02571626704302 0.128879042082556 no 476 0.15251267220313 736 67273
SGTC_2716 st080858 38.6235 µM 1.02443959429075 0.129175076694263 no 477 0.152813844238801 806 5296050
SGTC_2062 5245942 200 µM 1.02221044342237 0.129693101161223 no 478 0.15334065449834 816 1376160
SGTC_1563 conessine 56.1 µM 1.0200239827701 0.130202600989921 no 479 0.153858543361206 889 441082 An anti-amoebic, histamine inhibitor.
SGTC_2244 6635614 200 µM 1.01273315062851 0.131911547816683 no 480 0.155593819454617 653 836499
SGTC_2669 eugenol 100 µM 1.01235224778856 0.13200125348982 no 481 0.155684830824041 734 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2471 5466956 24.79 µM 1.00653855312084 0.133375647944115 no 482 0.157078287906796 782 724419
SGTC_796 1234-0020 70.7 µM 1.00514914879726 0.133705564228829 no 483 0.157412518425799 753 46495034
SGTC_2557 derrustone 83.84 µM 1.00425556027361 0.13391804447291 no 484 0.157627723942105 810 629853 An antioxidant.
SGTC_1642 st009582 77.7 µM 1.00394640322366 0.133991610794251 no 485 0.157702224117235 758 6739311
SGTC_322 k048-0136 19.3 µM 1.00389110122114 0.134004773262702 no 486 0.157715553144471 751 6823282
SGTC_2905 7799065 20.05 µM 1.00320279315068 0.134168672295591 no 487 0.157881512803989 767 1296806
SGTC_1350 1495-0454 146 µM 1.0029209127252 0.134235833026818 no 488 0.157949510776201 833 1069057
SGTC_790 1575-0012 79.1 µM 1.00239735683509 0.134360636533212 no 489 0.158075859102042 834 378741 YLR208W SEC13
SGTC_3032 9089427 49.47 µM 1.00114195194802 0.134660220270518 no 490 0.158379092762671 762 17173707
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.996752179504178 0.135711376682665 no 491 0.159442407602185 853 676296 Flavone; oxidizing agent.
SGTC_1154 4088-0362 150 µM 0.994732481220842 0.136196887983344 no 492 0.159933196202423 867 6618304
SGTC_3236 9132701 49.47 µM 0.992520157450749 0.136730066741022 no 493 0.160471925683616 802 24282524
SGTC_855 0428-0020 25 µM 0.990724944024682 0.137163767728589 no 494 0.160909953763287 736 6812414
SGTC_1114 scopoletin 1.73284 µM 0.99031304706164 0.137263409254842 no 495 0.161010565684801 810 5280460 A coumarin with genotoxic properties.
SGTC_2490 carminic acid 95.39 µM 0.989111368218517 0.137554388473492 no 496 0.161304328071648 740 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_722 3534-0461 190 µM 0.988335872021481 0.137742393548121 no 497 0.161494091341365 809 658262
SGTC_2231 micatex 6.853 µM 0.987767576464189 0.137880277842203 no 498 0.161633245168647 815 20737 An antifungal of unknown mechanism.
SGTC_3016 9080866 49.47 µM 0.987093098683001 0.138044047053338 no 499 0.161798500355225 827 17066299
SGTC_3280 9140961 49.47 µM 0.987063252598548 0.138051297012205 no 500 0.161805815548541 776 4901226
SGTC_1079 idarubicin 2.36 µM 0.985713627087625 0.138379408030378 no 501 0.162136830260452 793 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1654 st012436 41.8 µM 0.985221048351051 0.138499292434414 no 502 0.162257751914502 771 4323132
SGTC_725 1497-0963 19 µM 0.984418754296321 0.138694707198421 no 503 0.162454830298795 853 3549977
SGTC_2306 7482397 179.52 µM 0.981439764089466 0.139421942700671 no 504 0.163187962583086 809 891448
SGTC_1296 1068-0102 11.9 µM 0.980101062118161 0.139749591863228 no 505 0.163518117472988 830 767053
SGTC_1722 st034304 3.6505 µM 0.979718909355053 0.13984322024895 no 506 0.163612444721979 813 4036148 YLR033W RSC58
SGTC_3336 9143619 71.43 µM 0.979466772046981 0.139905017862862 no 507 0.16367469943305 876 45595730
SGTC_810 3825-7150 143 µM 0.977187578832361 0.140464479066495 no 508 0.164238148099989 886 22330411 YGL099W LSG1
SGTC_1239 0337-0584 35.4 µM 0.975163408493422 0.140962613018446 no 509 0.164739604842746 890 914301 YML130C ERO1
SGTC_1656 st012921 11 µM 0.974795863582013 0.141053191594639 no 510 0.164830764672815 766 6732821
SGTC_971 1315-0384 26.7 µM 0.973077628481035 0.141477160750949 no 511 0.165257360919056 795 6769120
SGTC_940 3232-1287 54.8 µM 0.971957402420423 0.141754037602612 no 512 0.16553587039641 837 1585493 YIL048W NEO1
SGTC_383 2324-0395 7.37 µM 0.968925492458073 0.142505249100504 no 513 0.166291182611402 835 3146421
SGTC_2180 6301957 200 µM 0.968554716208001 0.14259730016592 no 514 0.166383703232707 872 845462
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.965127441377041 0.143450078769522 no 515 0.167240491918196 763 521171
SGTC_228 caffeine 993.056 µM 0.960335149714308 0.144648264809415 no 516 0.168443282505631 797 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2394 5221648 200 µM 0.960128111458214 0.14470018073278 no 517 0.168495370925815 938 788586
SGTC_189 3970-0742 2.116 µM 0.957981187746945 0.145239272868781 no 518 0.169036122407813 857 2891807
SGTC_564 3555-0129 330 µM 0.954871135539436 0.146022600281053 no 519 0.169821434118869 767 563260
SGTC_186 3455-3465 67.277 µM 0.951837905765639 0.146789307747752 no 520 0.170589597367276 795 755278
SGTC_3340 9146634 11.102 µM 0.951716727403162 0.146819993921733 no 521 0.170620331841604 845 4907387
SGTC_851 0394-0702 453 µM 0.950367233926624 0.14716201893496 no 522 0.170962843478518 901 762646
SGTC_430 0958-0115 16.4 µM 0.949107544426373 0.147481765048682 no 523 0.171282958843797 809 6833180
SGTC_1726 st035556 14.5795 µM 0.9483988684848 0.147661852210533 no 524 0.171463217626356 898 5919439
SGTC_281 1672-3440 14.9 µM 0.948166642233444 0.147720897057142 no 525 0.171522313050297 909 6833000
SGTC_877 0771-0151 33.1 µM 0.948089313600266 0.147740561811006 no 526 0.171541994025409 872 6166523
SGTC_1333 1482-0047 286 µM 0.948025595006724 0.147756766834601 no 527 0.171558212182307 901 3811116
SGTC_1768 st044301 37.178 µM 0.943528935800623 0.14890337122386 no 528 0.17270521097142 876 3931349
SGTC_579 4491-1009 110 µM 0.941357035592107 0.149459308344121 no 529 0.173260961658781 1069 1271041
SGTC_1360 1598-0022 39.8 µM 0.938647298384006 0.150154854685183 no 530 0.173955930027716 937 761525
SGTC_784 4579-0127 173 µM 0.937823261009218 0.150366799099946 no 531 0.17416762250231 930 1948547
SGTC_1278 0874-0585 172 µM 0.937332192070163 0.150493197968036 no 532 0.17429385431404 863 766306
SGTC_1763 st044482 94.5 µM 0.933270890011375 0.151541271026011 no 533 0.175340060558603 890 88505
SGTC_1881 5652484 16 µM 0.930732370709541 0.152198828322659 no 534 0.175996010285395 839 2255129
SGTC_3040 9091894 49.47 µM 0.930623909794803 0.152226965288518 no 535 0.1760240709972 794 25236966
SGTC_2224 6650123 117.647 µM 0.927457399422378 0.153049944652877 no 536 0.176844550207426 856 2908370
SGTC_1630 st005209 31.3 µM 0.927269640807478 0.15309883576469 no 537 0.176893276418088 946 3367314
SGTC_1648 st011736 69.8 µM 0.925796656594519 0.153482750321627 no 538 0.177275832520305 860 2855514
SGTC_2624 nerol 100 µM 0.925011237626455 0.153687720180377 no 539 0.177480031012782 867 637566 A natural product oil.
SGTC_571 k831-0106 44.2 µM 0.924090324125371 0.153928280599672 no 540 0.177719645301894 840 4783639
SGTC_743 1275-0778 158 µM 0.922336700518673 0.154387049650651 no 541 0.178176488130444 918 2849257 YMR203W TOM40
SGTC_489 paxilline 115 µM 0.920949242639711 0.154750665269835 no 542 0.17853846382188 836 105008 A toxic potassium channel blocker.
SGTC_1647 st011722 22.4 µM 0.920538543985526 0.154858406851731 no 543 0.17864570030853 842 2854783
SGTC_497 capsazepine 133 µM 0.919965871341829 0.155008722952109 no 544 0.178795297105227 892 2733484 A calcium channel blocker.
SGTC_374 0880-0231 82.3 µM 0.916273099186238 0.155980321293309 no 545 0.179761836830116 901 6833587
SGTC_2736 butenafine 14.65 µM 0.916231157899249 0.155991379390591 no 546 0.179772833287849 913 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1455 4262-0120 131 µM 0.91551496659327 0.156180287701762 no 547 0.179960674511073 920 1529587
SGTC_1452 4194-0072 190 µM 0.915315470674721 0.15623293516001 no 548 0.180013019841435 966 1343545
SGTC_2695 st077686 51.995 µM 0.912893019856657 0.156873158681682 no 549 0.180649404495433 853 2876092
SGTC_3178 9107506 49.47 µM 0.91190173070906 0.15713564105672 no 550 0.180910225206385 875 8897194
SGTC_1212 0520-0165 585 µM 0.911642304904018 0.157204381790389 no 551 0.180978522361078 861 5403258
SGTC_2598 perillyl alcohol 100 µM 0.91120205222024 0.157321081938545 no 552 0.181094461468242 909 10819 An apoptosis inducer.
SGTC_387 norethindrone acetate 66.7 µM 0.908717100517428 0.157980849130922 no 553 0.181749737592194 844 541197
SGTC_2623 humulene 100 µM 0.906330684839714 0.158616162035427 no 554 0.18238042441459 768 6187145 An anti-inflammatory.
SGTC_3306 9127676 59.7925 µM 0.905939134133874 0.158720560648725 no 555 0.182484034663479 874 41905287
SGTC_1253 0550-0034 176 µM 0.902780283517664 0.159564447864255 no 556 0.183321258666676 839 5969915
SGTC_2455 5377712 9.75 µM 0.902148903407963 0.159733472616001 no 557 0.183488886855707 812 2243908
SGTC_3266 9136860 49.47 µM 0.896999922257228 0.161116261430492 no 558 0.184859479254485 881 4871271 YPR165W RHO1
SGTC_2735 sertaconazole 140 nM 0.89635483636778 0.161290051957745 no 559 0.185031640200507 901 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2436 5633522 8.09 µM 0.896288882227632 0.161307827339282 no 560 0.185049247695853 950 5724242
SGTC_2164 5685496 200 µM 0.895203539016671 0.161600523040203 no 561 0.185339146630086 927 759046
SGTC_2058 5236698 133 µM 0.893224994923295 0.162134987713778 no 562 0.185868347673186 887 766665
SGTC_352 k048-0007 5.11 µM 0.890143982404711 0.162969551699526 no 563 0.186694289492054 960 6811911
SGTC_2035 5154463 94.595 µM 0.889652833057969 0.163102848566733 no 564 0.186826163914772 908 2769623
SGTC_1298 1079-1278 263 µM 0.88890938823352 0.16330475265138 no 565 0.187025889743097 946 2840950
SGTC_1228 0124-0032 52.5 µM 0.886221277998798 0.164036141620682 no 566 0.187749149911709 964 X1228
SGTC_2319 6033012 152.6 µM 0.884625574080984 0.164471309034178 no 567 0.188179304377879 848 847246
SGTC_171 k064-0041 9.68 µM 0.882494509373567 0.165053641567312 no 568 0.188754723824977 840 53325
SGTC_2994 9053520 71.4286 µM 0.881916114160755 0.16521192327938 no 569 0.188911086125195 938 4647384
SGTC_453 enantio-paf c16 10 µM 0.879856739929025 0.165776282084183 no 570 0.189468461214494 994 13871343 A lipid and platelet activating factor
SGTC_1966 st070145 16.1 µM 0.878347066393535 0.166190789564202 no 571 0.189877700515067 927 3748532
SGTC_1301 naphtanilide LB 4.81 µM 0.875963367030682 0.166846638091056 no 572 0.190524974509402 1011 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_477 mead ethanolamide 10 µM 0.875926104687799 0.166856903649136 no 573 0.190535103534952 812 16061185
SGTC_2491 paeonol 100 µM 0.873413650944368 0.167550009825124 no 574 0.191218826524151 922 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3182 9108849 49.47 µM 0.873241401926308 0.167597595696587 no 575 0.191265756292397 975 17133045
SGTC_2163 5671233 125 µM 0.873164009238491 0.167618979195338 no 576 0.19128684446383 988 701023
SGTC_949 1165-0505 146 µM 0.872405724618577 0.167828585198334 no 577 0.191493539314089 969 6244267
SGTC_456 gingerol 170 µM 0.872313035541613 0.16785421800092 no 578 0.191518814083869 1000 442793 A herb.
SGTC_1782 st039423 80.636 µM 0.87196849939008 0.167949520224538 no 579 0.191612781278733 876 2068169
SGTC_1505 k297-0037 20.6 µM 0.870196138229061 0.16844032372893 no 580 0.192096612997627 930 4089396
SGTC_382 3229-0966 23.2 µM 0.869670297911069 0.168586117031975 no 581 0.192240304283585 983 5722370
SGTC_1525 8-methoxypsoralen 92.5 µM 0.868714144815141 0.168851425679355 no 582 0.192501751376387 1012 4114 Related to psoralen; DNA damaging agent.
SGTC_2214 7179297 48.276 µM 0.866775534879288 0.169390164442372 no 583 0.193032504688972 966 769744
SGTC_3019 9081971 49.47 µM 0.866623738011739 0.169432395240696 no 584 0.193074101377692 1011 16451803
SGTC_2877 9040724 71.43 µM 0.866537623198635 0.169456355901338 no 585 0.193097701735439 956 6463895
SGTC_1389 3405-0187 19 µM 0.865970900389073 0.169614095587446 no 586 0.193253059956273 872 799890
SGTC_195 4234-0266 16.654 µM 0.865915343117138 0.169629564276328 no 587 0.193268294220816 970 2303354
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.864475007448057 0.170030909592092 no 588 0.193663501967783 954 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1778 st046819 58.9 µM 0.864350677447733 0.170065582296594 no 589 0.193697639451475 1051 671715
SGTC_650 1328-0195 38 µM 0.863824779828406 0.170212292856554 no 590 0.193842076565565 968 2780821
SGTC_1912 st060209 90.8 µM 0.863587096496911 0.170278626382113 no 591 0.193907377525736 914 688787
SGTC_2227 7312221 64.1025 µM 0.86269107018706 0.170528841524289 no 592 0.194153671710848 972 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3342 9147791 14.508 µM 0.861295234408472 0.170919097132209 no 593 0.194537729866419 973 1838168
SGTC_3265 9137266 49.47 µM 0.860479550550686 0.171147414917964 no 594 0.194762375625863 942 17224265
SGTC_19 0279-0214 38.434 µM 0.859634650044442 0.17138411627635 no 595 0.194995234185138 1065 3566274 YBR002C RER2
SGTC_2549 cedrol 20.94 µM 0.859335908458628 0.17146785965924 no 596 0.195077609262454 943 6708665 A sedative which affects the nervous system.
SGTC_2846 9008642 19.48 µM 0.859160684993089 0.171516990549806 no 597 0.195125935264189 905 2992898
SGTC_2807 7945238 51.95 µM 0.855373636458913 0.172581038426847 no 598 0.196172166890072 955 17148797
SGTC_592 k241-0073 46.5 µM 0.853213996481835 0.173189713447404 no 599 0.196770321497489 1009 4230158
SGTC_1268 0828-0275 2.46 µM 0.852624704589471 0.173356037175473 no 600 0.196933729047534 1008 745337
SGTC_2318 6029776 164 µM 0.850914938285514 0.17383918267497 no 601 0.197408303016822 964 818325
SGTC_1539 benzyladenosine 56 µM 0.846959382839698 0.174960221722878 no 602 0.198508880653462 978 92208 A nucleotide analog.
SGTC_2074 5212007 75.395 µM 0.846729804083614 0.175025426893146 no 603 0.198572871158772 925 758611
SGTC_823 0417-1665 178 µM 0.846715701080504 0.175029432943691 no 604 0.198576802495562 979 3429856
SGTC_327 1273-0057 3.96 µM 0.846653818650884 0.1750470117414 no 605 0.198594053324795 946 3108138
SGTC_3124 9127567 49.47 µM 0.846230867656042 0.175167188433067 no 606 0.198711982645206 944 17592030
SGTC_3333 9141820 12.094 µM 0.844821509365034 0.175568019086104 no 607 0.199105251679184 932 1939433
SGTC_525 k781-2675 26.7 µM 0.841857372715306 0.176412933906113 no 608 0.19993389660173 1025 3651118 YDL195W SEC31
SGTC_2464 5717415 7.67 µM 0.841140699039193 0.176617604282439 no 609 0.200134558573503 968 5285744
SGTC_180 1486-1293 102.781 µM 0.840551053214413 0.176786110111057 no 610 0.200299744658868 999 4140536
SGTC_1456 k015-0012 13 µM 0.839968793818862 0.176952604775903 no 611 0.200462941834854 1069 2989616
SGTC_3253 9135987 49.47 µM 0.837746158446975 0.177589068804284 no 612 0.201086641750596 932 4182430
SGTC_78 0336-0123 156.75 µM 0.837078908418539 0.177780421178048 no 613 0.20127410754831 894 6765896
SGTC_1709 st033179 39.1045 µM 0.836683974160181 0.177893740735802 no 614 0.201385114797586 1013 573381
SGTC_303 1348-1668 34.2 µM 0.836426758851496 0.177967568712784 no 615 0.201457432036491 971 5380509
SGTC_24 0417-1663 219 µM 0.836232554861327 0.178023323480659 no 616 0.201512043669629 1004 4329390
SGTC_2442 5158906 48.48 µM 0.834754909133618 0.178447907082663 no 617 0.201927859283831 996 1893835
SGTC_614 0462-0418 107 µM 0.833748752450617 0.178737378775227 no 618 0.202211289653233 915 5188303
SGTC_2919 7978188 46.38 µM 0.832949593865729 0.178967507562651 no 619 0.202436578972983 1003 2980291
SGTC_2465 5809242 33.21 µM 0.832706348367581 0.179037590470675 no 620 0.202505181643658 1007 2731748
SGTC_425 3825-7017 13.1 µM 0.832387821913128 0.179129389129514 no 621 0.202595036860397 1003 3397440
SGTC_1022 4477-0945 21.3 µM 0.830568273970001 0.179654346544518 no 622 0.203108781801333 984 4648966
SGTC_1196 1588-0294 184 µM 0.829189841296101 0.180052680780199 no 623 0.203498496218088 940 6144269
SGTC_765 1319-0117 244 µM 0.827943830156528 0.18041322512223 no 624 0.203851155571127 1009 3487746 YGL099W LSG1
SGTC_928 2764-0428 58.7 µM 0.827914806338958 0.180421628815097 no 625 0.203859374540141 1017 662578
SGTC_1638 st008370 60.6 µM 0.827587762517596 0.180516339597403 no 626 0.203952000508961 995 24207134
SGTC_788 1182-0090 188 µM 0.826279731016979 0.180895452791743 no 627 0.20432271431338 1088 5715185
SGTC_1157 4092-0394 27.6 µM 0.825108525594064 0.181235332124941 no 628 0.204654989940037 1069 3659885
SGTC_804 1595-0054 20.9 µM 0.824481612361517 0.181417424171654 no 629 0.204832979723901 952 761523 Stimulates phospholipase C.
SGTC_1540 guanosine 70.6 µM 0.823905016845856 0.181585002107696 no 630 0.204996764816974 957 6802 Guanosine is a purine nucleoside
SGTC_2125 5246583 200 µM 0.823330413814974 0.181752097301012 no 631 0.205160061357205 1066 835267
SGTC_2073 5212005 126 µM 0.822902808899951 0.181876507688649 no 632 0.20528163262535 884 691789
SGTC_2050 5263056 171 µM 0.822726471128914 0.181927828150166 no 633 0.205331779230084 1045 763468 YGL055W OLE1
SGTC_3292 9120825 59.784 µM 0.822438183197553 0.182011749528753 no 634 0.2054137776818 1037 24824900
SGTC_935 2996-0153 430 µM 0.821987248826149 0.182143066248777 no 635 0.20554207705675 1015 23738523
SGTC_2719 novobiocin 32.65 µM 0.821967497991964 0.182148819247978 no 636 0.205547697630747 974 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_618 k072-0232 33.2 µM 0.821290759453903 0.182346007450392 no 637 0.205740334948735 985 5872756 YGL099W LSG1
SGTC_1170 0310-0127 64.8 µM 0.821098119717571 0.18240216323198 no 638 0.205795190484432 1016 774975
SGTC_799 1310-0557 151 µM 0.820201842863933 0.182663576026447 no 639 0.206050525792158 998 5354492
SGTC_1150 3909-7983 10.9 µM 0.819406072564319 0.182895870504221 no 640 0.206277385720095 997 23965914
SGTC_2831 7999036 19.48 µM 0.817267653776099 0.1835210123356 no 641 0.206887743765066 1031 2988270
SGTC_2023 5144124 124 µM 0.813705262342426 0.184565389157606 no 642 0.207906909390641 1000 2830192
SGTC_2721 ifenprodil 61.44 µM 0.813644492122142 0.18458323700485 no 643 0.207924320838883 1013 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2119 5528445 120.635 µM 0.813331685343645 0.184675123449501 no 644 0.208013957617284 1013 791935
SGTC_2539 epi(13)torulosol 80 µM 0.81162547096579 0.185176821421027 no 645 0.20850328564938 1014 6708597
SGTC_2065 5221596 34.26 µM 0.810715256521141 0.185444808223542 no 646 0.208764604941392 991 788581
SGTC_2790 5423970 71.43 µM 0.810505481848894 0.185506604537801 no 647 0.20882485784996 1040 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_944 3370-0224 231 µM 0.809437122044272 0.18582152476423 no 648 0.209131878360198 1035 4580514
SGTC_3133 9127736 49.47 µM 0.809218288952172 0.185886071046895 no 649 0.209194798424577 1032 27243420
SGTC_2438 5259590 200 µM 0.804954503754298 0.187146476321183 no 650 0.210422967233708 1057 1201127
SGTC_2867 9039098 71.43 µM 0.803586702223154 0.1875519253506 no 651 0.210817852732315 1002 6463460
SGTC_675 1309-0189 238 µM 0.80250996575999 0.187871477260274 no 652 0.211129012993333 1023 4246530
SGTC_190 3970-0790 3.722 µM 0.802460649703714 0.187886121238125 no 653 0.211143271017466 1015 2832352
SGTC_2291 7917025 104.35 µM 0.801805375458397 0.188080766173488 no 654 0.211332774351578 996 2964612
SGTC_624 k048-0052 28 µM 0.801724359412184 0.188104840103271 no 655 0.211356210866007 992 6835531
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.800428822729131 0.18849006734409 no 656 0.211731193570933 1006 17037758
SGTC_2963 9082507 9 µM 0.800342451028447 0.188515767217 no 657 0.211756207003084 983 16459611
SGTC_1387 3342-1166 1.8 µM 0.800107661412705 0.188585639714498 no 658 0.211824211324723 976 3418228
SGTC_1208 2323-2347 50.3 µM 0.800078390036156 0.188594351884225 no 659 0.211832690364172 1049 5412760
SGTC_1065 prochlorperazine maleate 2.48 µM 0.799760703184797 0.188688922392469 no 660 0.211924727484564 1087 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_752 1896-0090 130 µM 0.798416532561274 0.189089384802099 no 661 0.212314406200777 1033 772567
SGTC_3068 9116768 49.47 µM 0.795581755521268 0.189935650932796 no 662 0.213137587193225 1032 41904888
SGTC_350 k064-0020 19.8 µM 0.793190645285722 0.190651276416546 no 663 0.213833378474386 1071 2790705
SGTC_9 0092-0002 10.449 µM 0.792380177588804 0.190894212997777 no 664 0.214069516995562 1046 759368
SGTC_201 4262-0159 12.803 µM 0.791703338495397 0.191097240040796 no 665 0.214266837622809 1009 1341029
SGTC_2601 securinine 100 µM 0.791402836159664 0.1911874222099 no 666 0.21435447773958 1019 442872 A GABA receptor antagonist.
SGTC_3061 glucosamine 200 µM 0.789797387043961 0.191669666997621 no 667 0.21482305264743 1033 91431 and experimental redox chemotherapeutic
SGTC_2449 5812982 45.77 µM 0.788816209274188 0.191964759604633 no 668 0.215109717134363 1001 776185
SGTC_393 acivicin 6.25 µM 0.786735950869787 0.192591323600637 no 669 0.215718227057651 971 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1352 1496-0991 99 µM 0.785668149373628 0.192913425275013 no 670 0.216030963798809 1086 3000039
SGTC_2988 9073640 71.4286 µM 0.785230278835838 0.193045603727474 no 671 0.216159282820567 1028 9102229
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.784838162425364 0.193164017462051 no 672 0.216274230936614 1041 803109
SGTC_816 0325-0417 81.3 µM 0.784164209363318 0.19336764553709 no 673 0.216471881545782 1067 68101
SGTC_531 3788-1495 174 µM 0.7835837779681 0.193543121924342 no 674 0.216642188743948 994 2896655
SGTC_247 mechlorethamine 29.705 µM 0.782969793179119 0.193728847867538 no 675 0.216822425329763 1013 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_80 0159-0065 512.242 µM 0.781933693642394 0.194042506752327 no 676 0.217126771137447 1007 1548079
SGTC_2565 isoliquiritigenin 100 µM 0.781600964819392 0.194143299498689 no 677 0.217224559854161 955 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2470 5664817 21.68 µM 0.780653406956094 0.194430515620543 no 678 0.217503185641215 1094 2859561
SGTC_2892 9047358 58.44 µM 0.779532756663521 0.194770531779669 no 679 0.217832974705956 1024 6466771
SGTC_856 0433-0016 11.3 µM 0.779187356039422 0.194875402552526 no 680 0.217934678579342 1072 3911780
SGTC_626 0214-0009 33 µM 0.778092776040317 0.195207966452227 no 681 0.218257160565284 1091 3437874
SGTC_1565 sinapyl alcohol 95.1 µM 0.777010497162134 0.195537131801687 no 682 0.218576288586639 1082 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.77691068089908 0.195567506984101 no 683 0.218605734605403 1063 442882
SGTC_3237 9133362 49.47 µM 0.776879341105426 0.195577044617653 no 684 0.218614980385026 1042 43845137
SGTC_3141 9094609 49.47 µM 0.775576204535011 0.195973877919275 no 685 0.218999627390554 999 25236309 YDL196W YDL196W
SGTC_2133 5320837 200 µM 0.773895587325644 0.196486382871628 no 686 0.219496269645019 1029 2841355
SGTC_2795 7780010 54.55 µM 0.771820594810267 0.197120271975736 no 687 0.220110346078993 1027 953673
SGTC_2139 5578692 56.4705 µM 0.771700946077563 0.197156861142543 no 688 0.220145785129923 1048 650991 YMR113W FOL3
SGTC_3149 9097855 49.47 µM 0.77144419091977 0.197235391993653 no 689 0.220221845113672 1058 25236625 YMR079W SEC14
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.769425148232031 0.197853593435359 no 690 0.220820482092372 1077 6708514
SGTC_2196 6573537 42.6665 µM 0.767310267247306 0.19850239287398 no 691 0.221448532695348 1095 2903087
SGTC_1620 st003704 16.5 µM 0.764731692898073 0.199295177406068 no 692 0.22221566495854 1086 2834414
SGTC_2484 5809818 12.04 µM 0.763630445198521 0.199634337022409 no 693 0.222543750437473 1048 2870548
SGTC_364 0083-0097 67.7 µM 0.762728051460712 0.199912512805519 no 694 0.22281279878965 1098 5207356
SGTC_1682 st012968 530 nM 0.761114367422152 0.200410534735575 no 695 0.223294379829086 1037 24207270
SGTC_1944 st076371 56.9 µM 0.760863778436125 0.200487939354777 no 696 0.223369217649089 1077 24208455
SGTC_1832 st054113 55 µM 0.759750998036226 0.200831883763255 no 697 0.223701719294889 1080 1251267
SGTC_1628 st004252 77.7 µM 0.759110469637246 0.201030022345757 no 698 0.223893238367384 1092 692968
SGTC_2981 9013952 38.96 µM 0.758220663061359 0.201305466183896 no 699 0.224159446602326 1060 2996344
SGTC_3150 9097574 49.47 µM 0.757630007405564 0.201488431309954 no 700 0.224336255461007 1080 17217476
SGTC_2607 solasodine 47.35 µM 0.757243871302915 0.201608097049991 no 701 0.224451885527183 1100 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2417 cerulenin 830 nM 0.756573494648278 0.201815951622112 no 702 0.224652712922052 1094 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2362 9071156 126 µM 0.754581933735402 0.202434204218673 no 703 0.225249933512494 1089 653133
SGTC_570 0987-0065 62.6 µM 0.754285967623781 0.202526179371364 no 704 0.225338763219487 1006 3104428
SGTC_2256 7954252 200 µM 0.752485908348828 0.203086108000002 no 705 0.225879450513252 1023 2972920
SGTC_1379 2144-0755 36.5 µM 0.752393237773687 0.203114959216316 no 706 0.22590730599597 1159 5392327
SGTC_775 4577-0580 57.3 µM 0.750786257146973 0.203615651011546 no 707 0.226390650740499 1133 2006902
SGTC_2213 7173844 200 µM 0.749153140682178 0.204125239348498 no 708 0.22688245439149 1123 892728
SGTC_1508 1080-0625 72.9 µM 0.74891833225456 0.204198570041422 no 709 0.22695321512098 1064 767111
SGTC_1384 3089-0840 101 µM 0.748556516271951 0.204311595912806 no 710 0.227062274592793 1083 1069836
SGTC_2750 bromebric acid 70.15 µM 0.745210923431792 0.205358472234939 no 711 0.228072110171967 1132 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1037 k284-1091 78.7 µM 0.744611860816049 0.205546261908637 no 712 0.228253197808807 1102 3334711
SGTC_2018 5133068 143 µM 0.744246525162513 0.205660834629931 no 713 0.228363672955889 1088 785362
SGTC_85 0868-0259 160.055 µM 0.743086576041197 0.206024856812433 no 714 0.228714633179746 1055 83173
SGTC_192 3455-0609 60.9 µM 0.742907581472627 0.206081063972905 no 715 0.228768817663988 1159 3769639
SGTC_1840 st055363 71 µM 0.739948728164859 0.207011508083311 no 716 0.229665552785221 1090 676033
SGTC_1206 3978-0017 132 µM 0.739299825282623 0.207215894609245 no 717 0.229862477694881 1116 3873677
SGTC_1288 0973-0013 65.5 µM 0.738455589031551 0.207481984327926 no 718 0.230118822566848 1151 4315430
SGTC_1444 4112-3581 28 µM 0.738292721172147 0.207533340892715 no 719 0.230168294349686 1137 2877249
SGTC_2184 6075246 200 µM 0.735615026126539 0.208378765885703 no 720 0.230982507730454 1120 2267320
SGTC_2661 dactinomycin 12.96 µM 0.735328742298619 0.208469273932004 no 721 0.23106965380627 1140 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1555 citronellol 128 µM 0.734074766825233 0.208865988781174 no 722 0.231451585685035 1114 8842 A terpine precursor.
SGTC_406 estrone 100 µM 0.733728733017639 0.208975540268299 no 723 0.231557041500593 1132 5870 A steroid.
SGTC_209 4077-0173 175.592 µM 0.731031144923199 0.209830734384078 no 724 0.232380064785609 1070 15993494
SGTC_2323 6148992 148.28 µM 0.730652079431836 0.209951071030312 no 725 0.232495846393213 1090 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2076 5212012 200 µM 0.730429802236067 0.210021653137728 no 726 0.232563753565918 1058 604802
SGTC_2345 9052315 157.45 µM 0.730084574025653 0.210131304863647 no 727 0.232669244958415 1118 6469265
SGTC_923 1900-2434 73.3 µM 0.72999015902631 0.210161298904393 no 728 0.232698099983002 1133 5910570
SGTC_2240 6690706 185.951 µM 0.729390928707446 0.210351722814828 no 729 0.232881282560133 1057 805876
SGTC_349 k015-0014 24 µM 0.728533594951774 0.21062434312641 no 730 0.233143505682168 1120 2196908
SGTC_2228 7354201 200 µM 0.724887113095724 0.21178618782195 no 731 0.234260643688955 1181 753451
SGTC_1888 azatryptophan 97.5 µM 0.723411762543728 0.212257328636785 no 732 0.234713473391586 1103 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2215 7188065 200 µM 0.721665684912237 0.212815714653776 no 733 0.23525002218218 1161 940217
SGTC_1406 3909-7906 11.9 µM 0.720995202253385 0.213030358957282 no 734 0.235456233301028 1176 X1406
SGTC_3211 9128781 49.47 µM 0.720448840047549 0.213205361442236 no 735 0.235624344133905 1084 17194361
SGTC_3164 9100705 49.47 µM 0.716701625715021 0.214407869895056 no 736 0.23677911128221 1151 17174235
SGTC_471 1-acyl-paf 4 µM 0.714289198682059 0.215184117860702 no 737 0.237524184947709 1135 16759367
SGTC_1248 0469-0687 58.6 µM 0.712169829155974 0.215867412637606 no 738 0.238179808738746 1163 4017482
SGTC_2284 7945075 39.21 µM 0.711196602020205 0.2161816064664 no 739 0.23848120697707 1249 1245402
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.707845865433333 0.217265371799657 no 740 0.239520490174499 1167 61125 An anti-inflammatory.
SGTC_2769 toremifene 3.73 µM 0.706438096151564 0.217721636488363 no 741 0.239957868343395 1192 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2614 arthonioic acid 13.39 µM 0.706282570489823 0.217772076978106 no 742 0.24000621512965 1143 6710684
SGTC_2865 9030313 51.95 µM 0.706076260551453 0.21783899835835 no 743 0.240070356937234 1132 42562754
SGTC_566 0958-0068 16.5 µM 0.706067553169433 0.217841823059096 no 744 0.24007306426984 1159 6815365
SGTC_293 4049-0273 38.5 µM 0.705494964963888 0.21802761874878 no 745 0.240251132120563 1115 1380311
SGTC_1523 st012844 44.7 µM 0.705077223679726 0.218163226713564 no 746 0.240381089887663 1184 4274103
SGTC_2720 fluspirilene 36.88 µM 0.704719865589813 0.218279271539233 no 747 0.240492293049705 1150 3396 An atypical antipsychotic.
SGTC_2622 2-methoxyxanthone 59.94 µM 0.704557348188766 0.218332057546529 no 748 0.240542874694656 1208 71034 A hepatoprotective.
SGTC_3009 9080819 71.4286 µM 0.703438094281888 0.218695793323184 no 749 0.240891386684047 1199 17027216
SGTC_1717 st033143 58.0435 µM 0.70157720207426 0.219301318495254 no 750 0.241471436638998 1193 674616
SGTC_1472 k841-0093 193 µM 0.701100578345624 0.219456564373653 no 751 0.241620124719655 1261 X1472
SGTC_1153 4055-0057 267 µM 0.698023921934291 0.22046021089006 no 752 0.24258111692702 1200 882706
SGTC_639 0833-0042 114 µM 0.697600955112831 0.220598393712071 no 753 0.242713392061175 1192 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1354 1498-1681 81 µM 0.697144675864466 0.220747515290972 no 754 0.242856128814698 1223 5754243
SGTC_3197 9113331 49.47 µM 0.696818718786282 0.220854080208031 no 755 0.242958125001878 1218 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2409 alverine citrate 63.97 µM 0.695421212825699 0.221311299555157 no 756 0.243395685243586 1222 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_720 r052-1644 49.9 µM 0.694158853025529 0.22172476834031 no 757 0.243791296852001 1172 1422863 YOR257W CDC31
SGTC_1651 st011928 86.1 µM 0.690861541546928 0.22280683730296 no 758 0.244826278274551 1203 720198
SGTC_2665 lovastatin 100 µM 0.690410657392788 0.222955036132477 no 759 0.244967988285556 1202 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_884 0851-0618 334 µM 0.690287899514157 0.22299539452032 no 760 0.245006577945069 1207 9642473
SGTC_2522 biochanin a 4.94 µM 0.689855452087196 0.223137600866734 no 761 0.245142546380539 1170 5280373 A possible chelator.
SGTC_3063 1327-0034 4 µM 0.689105531389311 0.22338432773054 no 762 0.24537842969324 1139 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_321 4534-3890 65.3 µM 0.688612052729233 0.223546768799934 no 763 0.245533717134569 1231 699746
SGTC_1210 3013-0140 750 nM 0.688299266685603 0.223649765071482 no 764 0.245632171707874 1223 905973
SGTC_1008 4106-0037 6 µM 0.687302017090866 0.223978326161414 no 765 0.245946214000859 1185 2905394
SGTC_1109 tnp00067 928.257 nM 0.686993342160722 0.224080079997289 no 766 0.246043461981245 1198 676295
SGTC_2528 xanthyletin 44.79 µM 0.686542087438103 0.224228882108615 no 767 0.246185666812306 1254 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1469 k284-2957 126 µM 0.686203950520921 0.224340420169935 no 768 0.24629225347597 1230 23884841
SGTC_3311 9131146 2.8755 µM 0.68571390164363 0.224502123891943 no 769 0.246446769340338 1189 4900406 YPR165W RHO1
SGTC_2832 7992762 51.95 µM 0.684724331483705 0.22482885852506 no 770 0.246758946077674 1119 2985177
SGTC_597 k018-0003 82.8 µM 0.684702421254045 0.224836095857791 no 771 0.246765860427234 1288 6786234
SGTC_160 3453-0671 289.699 µM 0.682057610017047 0.225710693097933 no 772 0.247601261690588 1192 5322268
SGTC_2689 tacrolimus 100 µM 0.681934701561556 0.225751383725243 no 773 0.247640120775765 1218 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1606 st000094 49.2 µM 0.680919066172688 0.226087783327643 no 774 0.247961351566566 1251 1242210
SGTC_68 0986-0284 82.829 µM 0.680718525457092 0.226154240069364 no 775 0.248024805973436 1184 423278 YIL048W NEO1
SGTC_1720 st037298 9.481 µM 0.679943542154723 0.226411163793826 no 776 0.248270104950071 1213 597396
SGTC_3055 9094636 49.47 µM 0.678649568550362 0.226840511179954 no 777 0.248679963705149 1254 25236176
SGTC_2005 4024620 188 µM 0.675736981918982 0.227808601516141 no 778 0.249603825743662 1233 236743
SGTC_2152 5568786 200 µM 0.67274412968503 0.228805788152143 no 779 0.25055504371239 1211 5399883
SGTC_882 0843-0131 351 µM 0.672581552461184 0.22886002723524 no 780 0.250606770559328 1260 5425421
SGTC_2099 5377090 177.372 µM 0.672452718960022 0.22890301384781 no 781 0.250647765255617 1218 2243829
SGTC_897 1000-0139 31.4 µM 0.671753261969071 0.229136473876248 no 782 0.250870393774436 1221 6151020
SGTC_1920 st075728 45.7 µM 0.671547641201564 0.229205129978383 no 783 0.250935860227143 1255 3400306
SGTC_1959 st077091 55.8 µM 0.670243543036337 0.229640832584533 no 784 0.251351275218518 1247 821356 YKL052C ASK1
SGTC_3103 9120822 49.47 µM 0.670017245481753 0.229716486399674 no 785 0.251423398351561 1302 17141819
SGTC_1956 st077085 54 µM 0.669320100909939 0.229949637377467 no 786 0.251645653535527 1241 24208685
SGTC_157 1348-1695 65.819 µM 0.666543952036249 0.230879397115089 no 787 0.252531740094313 1258 5380510
SGTC_2889 9059656 51.95 µM 0.665575644549031 0.231204185982327 no 788 0.252841189097374 1299 3949838
SGTC_932 2857-0803 154 µM 0.665549326424477 0.231213017142051 no 789 0.252849602555689 1329 674898
SGTC_2280 7785178 200 µM 0.665547676861396 0.231213570666295 no 790 0.252850129897953 1244 2954328
SGTC_2448 5185112 27.17 µM 0.664675935945582 0.231506193798327 no 791 0.253128894263349 1231 5718189
SGTC_2971 9092186 9.93 µM 0.663988369433935 0.231737139437622 no 792 0.253348877516259 1201 25236400
SGTC_707 0865-0008 204 µM 0.663905763980561 0.231764894288782 no 793 0.253375313452684 1256 723043
SGTC_2723 salbutamol 83.58 µM 0.663528246825328 0.231891760966248 no 794 0.253496147409302 1235 9884233 β2-adrenoceptor agonist
SGTC_2771 fluoxetine 41.05 µM 0.663070267926082 0.232045719155058 no 795 0.253642775827763 1256 3386 A selective serotonin reuptake inhibitor.
SGTC_1985 st071382 65.5 µM 0.662921249632994 0.232095826714592 no 796 0.253690495744338 1280 6123237
SGTC_177 1327-0068 8.361 µM 0.662409119101799 0.232268077060854 no 797 0.253854530515342 1256 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1017 4239-0030 168 µM 0.661104942959492 0.232707045629216 no 798 0.254272507786039 1230 1149593
SGTC_1124 fisetin 1.16336 µM 0.660167642452445 0.233022813229551 no 799 0.254573127252306 1252 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1575 cyproterone acetate 48 µM 0.658766227155803 0.233495380206419 no 800 0.255022948840125 1208 9880 An androgen receptor antagonist and liver toxin.
SGTC_3300 9124615 50.48 µM 0.658327218963106 0.2336435260856 no 801 0.255163945703435 1292 24824903
SGTC_2216 7189485 200 µM 0.657962278409721 0.233766717063922 no 802 0.255281185183544 1261 731273
SGTC_40 0327-0103 19.753 µM 0.65572913184152 0.234521331735836 no 803 0.255999210692005 1206 409036
SGTC_1125 tnp00248 1.32998 µM 0.65304857243827 0.235428910886607 no 804 0.256862482583195 1342 24207736
SGTC_76 0433-0009 400.328 µM 0.652271994635167 0.235692204912279 no 805 0.257112861531708 1262 2841569
SGTC_2120 5538279 151.968 µM 0.651877334099672 0.235826074399208 no 806 0.257240153927687 1298 2058197
SGTC_371 0195-0006 7.36 µM 0.651772917976757 0.235861499526813 no 807 0.257273837409614 1182 3928593
SGTC_1634 st006576 41 µM 0.651337305597776 0.236009320837152 no 808 0.257414385855411 1261 3915356
SGTC_781 4335-2806 94.4 µM 0.650594854531494 0.236261382827046 no 809 0.257654026383135 1362 845254
SGTC_824 1304-0008 100 µM 0.650212354777566 0.236391299255997 no 810 0.257777530815961 1266 768245
SGTC_1510 1123-0200 71.5 µM 0.649968923515907 0.236474001404827 no 811 0.257856147752632 1346 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2267 7931562 200 µM 0.649114851871502 0.236764285442527 no 812 0.258132071403541 1202 934880
SGTC_1090 efavirenz 20.7 µM 0.64836315979428 0.237019934509432 no 813 0.258375046042782 1288 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2880 9042983 58.44 µM 0.648324481470194 0.237033093037626 no 814 0.258387551510347 1288 6464714
SGTC_1814 st052110 31.539 µM 0.647816527112041 0.237205938493896 no 815 0.258551812303785 1255 674163
SGTC_1507 4075-3230 155 µM 0.647699354974536 0.237245819365162 no 816 0.258589710761042 1206 659771
SGTC_1334 1486-0610 236 µM 0.64730309262708 0.237380719051545 no 817 0.258717900183258 1276 3742339
SGTC_3109 9122853 49.47 µM 0.647146890197826 0.237433906652896 no 818 0.258768440135698 1336 1234709
SGTC_1911 st060208 74.3 µM 0.645698533422587 0.237927389831093 no 819 0.259237305280366 1306 688783
SGTC_3003 9075612 71.4286 µM 0.644665391415109 0.23827974465184 no 820 0.259572024318948 1271 6501993
SGTC_586 0957-0265 8.15 µM 0.642837324346092 0.238903909727122 no 821 0.260164830749122 1189 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2805 7950783 58.44 µM 0.642168159426634 0.239132609033481 no 822 0.260382002195116 1279 1178958 YDL195W SEC31
SGTC_338 4055-0136 114 µM 0.641796450680333 0.239259698945976 no 823 0.260502677249351 1240 2900563
SGTC_1185 1319-0113 81.3 µM 0.641497479565598 0.239361946106649 no 824 0.260599758961111 1302 4672763
SGTC_101 0490-5701 117.494 µM 0.64100122923454 0.239531714797697 no 825 0.260760942158908 1185 4661669
SGTC_686 1319-0111 510 µM 0.640394731106965 0.239739288818926 no 826 0.260958003715114 1357 4562600
SGTC_1689 st020265 53.493 µM 0.638708445952748 0.240316935499613 no 827 0.261506308623543 1303 5758320 YPR016C TIF6
SGTC_3161 9100388 49.47 µM 0.638465746616874 0.240400135931319 no 828 0.261585272311595 1316 25236368
SGTC_1235 benzylparaben 21.5 µM 0.637826046683404 0.240619508397178 no 829 0.261793461156591 1271 7180
SGTC_1697 st025554 27.742 µM 0.636405085264193 0.241107188713278 no 830 0.26225621361863 1254 1269519
SGTC_1413 3910-0535 34.4 µM 0.636013363738413 0.241241723720739 no 831 0.262383855886408 1316 2876951
SGTC_147 4466-0538 29.23 µM 0.635020215230405 0.241582998905138 no 832 0.262707615353702 1350 6742687 YHR072W ERG7
SGTC_2258 7960471 200 µM 0.634579056412147 0.241734678158752 no 833 0.262851495569095 1239 2974708
SGTC_607 4491-0986 66.8 µM 0.633765221225942 0.242014626601615 no 834 0.263117026722128 1335 698981 YDR232W HEM1
SGTC_2572 astragaloside iv 100 µM 0.633311249250285 0.242170863266747 no 835 0.263265204326287 1320 45006101 An anti-inflammatory agent.
SGTC_649 1123-0311 367 µM 0.631578807328911 0.242767593753794 no 836 0.263831069161331 1289 693629 YIL048W NEO1
SGTC_1437 4092-1038 11.6 µM 0.631363906487602 0.242841670660002 no 837 0.263901305101404 1276 3977136
SGTC_1703 st026983 48.3 µM 0.631015289373148 0.242961865941697 no 838 0.264015263736918 1315 1104023
SGTC_2658 polymyxin b sulfate 77.05 µM 0.629547313378844 0.243468343695351 no 839 0.264495401951562 1269 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2279 7948423 32.93 µM 0.624987131775261 0.245045318654324 no 840 0.265989751914776 1363 1247112
SGTC_279 1273-0055 2.93 µM 0.624957613219081 0.245055544453941 no 841 0.265999438920024 1338 2847562
SGTC_2692 st077426 47.7 µM 0.624319563606006 0.245276633291188 no 842 0.266208869184428 1287 25238571
SGTC_2313 7726885 200 µM 0.623480289321637 0.245567611154637 no 843 0.266484475501763 1304 726423
SGTC_2649 anisomycin 9.56 µM 0.621190919252214 0.246362281625202 no 844 0.267237006741726 1275 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_431 k089-0097 107 µM 0.621080517185512 0.246400638441905 no 845 0.267273323726431 1263 5499420
SGTC_1889 st059080 5.18 µM 0.620785140317365 0.246503276497952 no 846 0.267370500792303 1307 176925 Isolated from Daphnopsis sellowiana.
SGTC_562 3772-2733 112 µM 0.619852654786102 0.246827448404453 no 847 0.26767739936549 1314 2876874 YIL048W NEO1
SGTC_3054 9094397 49.47 µM 0.619745871768098 0.246864585312234 no 848 0.267712554996665 1289 2598354
SGTC_2872 9044037 25.97 µM 0.619428772840044 0.24697488333449 no 849 0.267816965579693 1322 6465195
SGTC_2652 actinonin 100 µM 0.618971543222863 0.247133970091093 no 850 0.267967552845121 1290 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1285 0929-0069 65.5 µM 0.618207135003109 0.247400057782238 no 851 0.268219403691303 1313 1206237
SGTC_3144 9087057 49.47 µM 0.617857158081164 0.247521934544096 no 852 0.268334750902975 1269 17249618
SGTC_2811 7967822 32.47 µM 0.615616568182562 0.248302962187159 no 853 0.269073806843572 1356 2232244
SGTC_1876 myriocin 605 nM 0.614473954181589 0.248701761291238 no 854 0.269451089627455 1398 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2699 st077704 54.6 µM 0.614325878075841 0.248753468283001 no 855 0.269500002676249 1333 645852
SGTC_368 fentichlor 4.58 µM 0.613052211128946 0.249198458864286 no 856 0.269920908739755 1291 7329 A pesticide.
SGTC_1287 0971-0001 34.6 µM 0.612664965058789 0.249333837806212 no 857 0.270048946339599 1334 4665869
SGTC_2941 9056145 11.23 µM 0.612251989998274 0.24947825452109 no 858 0.270185524352435 1227 2119517
SGTC_193 1273-0060 1.558 µM 0.61207750399827 0.249539285350112 no 859 0.270243240277696 1209 2847393 YHR072W ERG7
SGTC_2595 hexamethylquercetagetin 100 µM 0.610251854532374 0.250178327193605 no 860 0.270847492272965 1312 386331
SGTC_2593 nobiletin 86.24 µM 0.60921612388897 0.250541255037736 no 861 0.271190597114947 1276 72344 An anti-infammatory.
SGTC_2690 usnic acid 100 µM 0.608965259864367 0.250629201633643 no 862 0.271273733029011 1416 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1945 st075991 56.6 µM 0.607313197551914 0.251208781190538 no 863 0.271821540780615 1247 1084980
SGTC_146 3448-8650 53.125 µM 0.605657726306958 0.251790266890373 no 864 0.272371030505299 1347 2891488 YIL048W NEO1
SGTC_340 k038-0059 454 µM 0.604974837495043 0.252030339045429 no 865 0.27259785795763 1340 23733424
SGTC_1006 4099-6547 255 µM 0.60414922597117 0.252320747104168 no 866 0.272872217152068 1358 3146833
SGTC_109 0132-0036 33.701 µM 0.603920505146604 0.252401230628418 no 867 0.272948247650819 1231 67274 A color developer.
SGTC_2962 9082311 13.18 µM 0.603820380603825 0.252436467253245 no 868 0.272981533972409 1302 16459453
SGTC_2483 5729050 27.16 µM 0.601868003660485 0.253124081089495 no 869 0.273631002033471 1411 2865180
SGTC_3347 9188721 44.724 µM 0.60081840592948 0.25349414902107 no 870 0.273980471735671 1328 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2061 5245884 80.95 µM 0.600638002209195 0.253557784514527 no 871 0.274040560417902 1331 573863
SGTC_1478 0453-0656 35.7 µM 0.599881223688759 0.253824821503948 no 872 0.274292698349481 1348 5258496
SGTC_2007 4011539 71.82 µM 0.599156480015347 0.25408069299596 no 873 0.274534270470034 1361 45595301
SGTC_1018 4259-0013 28.1 µM 0.598387890641267 0.254352192015242 no 874 0.274790571906773 1356 6801262
SGTC_620 0109-0052 432 µM 0.598359258464498 0.254362309075978 no 875 0.274800122155002 1349 493037
SGTC_1144 3486-0183 12.5 µM 0.597923991832204 0.254516134704556 no 876 0.274945325269369 1341 6744069
SGTC_3344 9148862 3.898 µM 0.597479240522606 0.254673362598562 no 877 0.275093731471266 1398 4905352
SGTC_698 k064-0052 127 µM 0.596237127005116 0.25511274217349 no 878 0.275508413170817 1404 5088751
SGTC_2946 9065502 71.43 µM 0.595184236557313 0.255485497086663 no 879 0.275860163030594 1216 16489101
SGTC_1067 clotrimazole 1.36 µM 0.59395372620961 0.25592149513761 no 880 0.276271531597183 1350 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2512 diallyl trisulfide 49.23 µM 0.59331311089959 0.256148633426366 no 881 0.276485813033568 1321 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3286 9117135 37.221 µM 0.593209821657956 0.256185265776843 no 882 0.276520370205389 1311 3438150
SGTC_396 dithiazanine 1.25 µM 0.591668828792006 0.256732115360476 no 883 0.277036186885553 1314 10578 An antihelmenthic.
SGTC_2898 9056270 58.44 µM 0.590559556790129 0.257126136714774 no 884 0.277407784900105 1288 19154699
SGTC_128 0906-2981 13.371 µM 0.589930079424071 0.257349871355958 no 885 0.277618763536871 1385 6740226
SGTC_1341 1486-1360 280 µM 0.589683554946603 0.257437520916858 no 886 0.277701411213505 1345 3976547
SGTC_51 1013-0126 23.419 µM 0.588317309110337 0.25792355834569 no 887 0.278159664772627 1470 1627850
SGTC_3225 9130819 49.47 µM 0.587227844503545 0.25831147266876 no 888 0.278525347027966 1390 4547121
SGTC_3185 9108267 49.47 µM 0.587102544645197 0.258356106263307 no 889 0.278567419334193 1315 4910486
SGTC_1872 amphotericin b 148 nM 0.587031421100811 0.258381443260874 no 890 0.278591302075383 1351 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3127 9126946 49.47 µM 0.586970063576999 0.25840330225303 no 891 0.278611906262889 1310 27243249
SGTC_627 1391-0720 175 µM 0.586907134581954 0.258425722086567 no 892 0.278633038929737 1332 997839
SGTC_2564 betulinic acid 100 µM 0.586303858511861 0.258640703533002 no 893 0.278835669277516 1472 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_308 4092-1169 104 µM 0.585721107913622 0.258848458476177 no 894 0.279031473529684 1347 2268590 YDL196W YDL196W
SGTC_715 0868-0130 184 µM 0.58552955905111 0.258916765927951 no 895 0.279095848563416 1462 2876258
SGTC_3038 9091290 49.47 µM 0.58536326137483 0.258976076219286 no 896 0.279151743127367 1402 25236843
SGTC_3104 9120930 49.47 µM 0.584518236683465 0.259277563960169 no 897 0.279435849708877 1352 17014836
SGTC_1290 0986-0249 10.2 µM 0.584230100364683 0.259380406629738 no 898 0.279532756400872 1318 53329
SGTC_3145 9085516 49.47 µM 0.583709539860627 0.259566260405622 no 899 0.279707873906169 1352 25236195
SGTC_1914 st062367 72.6 µM 0.582058014126661 0.260156353275951 no 900 0.280263802284447 1373 978205
SGTC_2774 tamoxifen 10.92 µM 0.579018754878452 0.261244089921343 no 901 0.281288259187063 1387 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1772 st048439 82.2 µM 0.578814662603492 0.26131721722764 no 902 0.281357118219567 1346 2927068 YDL195W SEC31
SGTC_2485 5633444 17.78 µM 0.577967361204227 0.261620922057688 no 903 0.281643077618854 1328 5724239
SGTC_1922 5578187 25 µM 0.575219710840255 0.262607028458975 no 904 0.282571356880727 1453 1350412
SGTC_1769 st044406 64.4 µM 0.574903799879874 0.262720527785574 no 905 0.282678179944454 1378 670903
SGTC_732 3970-1727 52.7 µM 0.574717292358211 0.26278754730021 no 906 0.282741255257196 1448 1275699
SGTC_695 3505-6186 243 µM 0.574667635139755 0.262805392572822 no 907 0.282758050060636 1406 1819379
SGTC_2545 solidagenone 89.61 µM 0.573496795415278 0.263226335763972 no 908 0.283154184131657 1282 6708572 An anti ulcer agent
SGTC_1961 st076550 68.7 µM 0.5733113638015 0.263293034173053 no 909 0.28321694623879 1377 1579337
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.572914981600376 0.263435638919719 no 910 0.283351130106725 1386 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2045 5106652 78.05 µM 0.572655459997883 0.263529027261363 no 911 0.283439000239107 1383 673349
SGTC_616 4092-0450 108 µM 0.571903454547232 0.263799730328841 no 912 0.283693691771106 1411 787165
SGTC_1057 3448-5381 134 µM 0.57134253320561 0.264001740205353 no 913 0.283883737689569 1427 5497911
SGTC_2407 paclitaxel 400 µM 0.568425012066353 0.265053724376791 no 914 0.284873205348216 1529 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1180 1193-0155 285 µM 0.568068415257137 0.265182450042201 no 915 0.284994256725001 1359 2921347
SGTC_2071 5230951 39.92 µM 0.566740962873634 0.265661917716829 no 916 0.285445093005687 1392 1799272
SGTC_837 0091-0265 12.5 µM 0.565529823053422 0.266099757182877 no 917 0.285856722631698 1357 759367
SGTC_3131 9127911 49.47 µM 0.5650879226129 0.266259599664692 no 918 0.286006981411965 1427 45595681
SGTC_633 0437-0093 97.7 µM 0.56393905111002 0.266675392223023 no 919 0.28639780611461 1391 2831118
SGTC_194 1486-1323 56.904 µM 0.563925423208492 0.266680326319094 no 920 0.286402443593875 1359 5178754
SGTC_1093 fluphenazine 7.97 µM 0.563236417767863 0.266929846653407 no 921 0.286636953749314 1438 6602611 An atypical antipsychotic.
SGTC_260 nsc-65238 3.989 µM 0.563235618882932 0.266930136034557 no 922 0.286637225710941 1404 3246252
SGTC_2798 7813637 45.45 µM 0.562538046250517 0.267182879162879 no 923 0.286874744635006 1428 956368
SGTC_2580 diallyl disulphide 81.36 µM 0.562021150088824 0.267370237834724 no 924 0.287050804537545 1416 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_269 exalamide 29 µM 0.561343965451751 0.26761579631186 no 925 0.287281537669537 1443 3316 A derivative of salicylamide.
SGTC_1984 st072354 53.1 µM 0.560522033827371 0.26791399512121 no 926 0.287561707439867 1372 5762938
SGTC_301 4119-0100 24.5 µM 0.559629242695117 0.268238091429626 no 927 0.287866177191009 1402 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_187 1488-2104 32.728 µM 0.558553820053326 0.268628747397156 no 928 0.288233132028507 1451 2852859
SGTC_418 lividomycin a 100 µM 0.558257485977839 0.268736443369115 no 929 0.288334285661405 1378 72394 An antibiotic.
SGTC_1880 MG-132 525 µM 0.557957164149121 0.268845610726029 no 930 0.288436817588416 1395 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1251 0490-5699 265 µM 0.557576844855713 0.268983889212059 no 931 0.288566685853701 1446 3883818
SGTC_483 fpl-64176 144 µM 0.556989003656332 0.269197689817386 no 932 0.288767471152177 1412 3423
SGTC_169 k015-0017 16.025 µM 0.555080095532095 0.269892556046902 no 933 0.289419938337091 1478 1840002
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.554987764520323 0.269926188430427 no 934 0.289451514743489 1302 6708630 An antioxidant.
SGTC_330 1488-0319 80.1 µM 0.554484902620831 0.270109397118641 no 935 0.289623517557691 1412 6846614
SGTC_2429 5902844 64.44 µM 0.55407178040344 0.270259957298119 no 936 0.289764861001021 1450 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2245 6637752 200 µM 0.553852768090086 0.270339792178913 no 937 0.28983980583668 1461 681890
SGTC_3025 9087895 49.47 µM 0.552944321124615 0.270671067207262 no 938 0.290150768539561 1423 17173641
SGTC_1081 sertraline 6 µM 0.552054505846817 0.270995744395543 no 939 0.290455505058546 1444 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_216 k038-0035 28.382 µM 0.549089634885772 0.272078971424631 no 940 0.29147196904043 1375 4444231 YPR107C YTH1
SGTC_3260 9137109 49.47 µM 0.54691483116757 0.272874910745564 no 941 0.292218622972035 1400 17478346
SGTC_1859 st055998 20 µM 0.546623272022064 0.272981703906573 no 942 0.292318788705839 1529 676301
SGTC_1657 st012939 43.4 µM 0.545069194125091 0.273551285586584 no 943 0.292852964505425 1457 24207257
SGTC_2899 9053889 58.44 µM 0.542978125086304 0.27431860567821 no 944 0.293572431881943 1415 6470052
SGTC_1797 st048695 56.8 µM 0.542332522556115 0.274555724746232 no 945 0.293794727495876 1454 592262 YIL048W NEO1
SGTC_2185 6113692 200 µM 0.541824276317122 0.27474246624274 no 946 0.29396978298707 1417 874150
SGTC_604 1000-0114 314 µM 0.541453562357071 0.274878714665736 no 947 0.294097498581253 1501 1572745
SGTC_343 4130-2827 29.8 µM 0.541226857604488 0.27496205182086 no 948 0.294175613837114 1405 1118244
SGTC_664 1222-0054 14.9 µM 0.539344630839462 0.275654442785033 no 949 0.294824539276009 1404 6813991
SGTC_899 1083-0020 478 µM 0.538733204959007 0.275879544599043 no 950 0.295035479272587 1482 767123
SGTC_358 0075-0058 9.45 µM 0.538601345804503 0.275928101541238 no 951 0.29508097937565 1522 1069125
SGTC_2019 4016004 108 µM 0.538240090881303 0.276061154643979 no 952 0.295205652698047 1380 45595336
SGTC_1831 st055328 12 µM 0.537321271614618 0.276399705076889 no 953 0.295522857253537 1488 1103068
SGTC_2002 4023503 131 µM 0.537206687055808 0.276441939465027 no 954 0.295562426342432 1503 4736863 YCR052W RSC6
SGTC_2670 beta-carotene 100 µM 0.537070649738467 0.276492085171484 no 955 0.29560940680062 1375 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2768 sulfasalazine 50.2 µM 0.536633322120481 0.276653321899628 no 956 0.295760461050927 1555 5384001 An antioxidant and salicylic acid derivative.
SGTC_1219 1469-0211 33.1 µM 0.534722551449539 0.277358336985922 no 957 0.296420862472502 1436 6822282
SGTC_2040 5100729 123 µM 0.533432401180752 0.277834858704573 no 958 0.29686714669529 1462 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2828 7998861 71.43 µM 0.532478447455824 0.27818746184503 no 959 0.297197332605928 1442 2988188
SGTC_1113 artemisinin 1.17947 µM 0.532134600913763 0.278314608883273 no 960 0.297316387157495 1459 2240 An anti-malaria and mitochondrial poison.
SGTC_225 nsc-122657 1.016 µM 0.530957319100159 0.278750156728879 no 961 0.297724177992636 1435 275685
SGTC_2303 7774051 200 µM 0.529673981566143 0.279225318658072 no 962 0.298168995225371 1506 2953184
SGTC_1089 terbinafine 2.25 µM 0.529025553958351 0.279465551727132 no 963 0.298393861577045 1483 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2294 7971431 200 µM 0.528763306489945 0.279562739127762 no 964 0.298484827539668 1450 5741572
SGTC_891 0929-0073 133 µM 0.527419183873575 0.280061120638593 no 965 0.298951262215556 1498 5603632
SGTC_2932 9016711 44.54 µM 0.52699012950148 0.280220298509774 no 966 0.299100221459599 1527 7117328
SGTC_2925 9010536 32.5 µM 0.526330844216529 0.280464976736126 no 967 0.299329177990964 1527 2994177
SGTC_2845 9003024 42.97 µM 0.526202752489032 0.280512526963596 no 968 0.29937367089529 1522 2990173
SGTC_1465 k213-0056 144 µM 0.526181525203642 0.280520407336057 no 969 0.299381044522797 1413 24048857 YMR208W ERG12
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.524915042881249 0.280990767341627 no 970 0.299821125799879 1420 688803
SGTC_2203 7227154 166.4 µM 0.523994440711138 0.281332909636856 no 971 0.300141203263962 1441 896304
SGTC_2729 fluphenazine 10.66 µM 0.522639195315575 0.281836952940131 no 972 0.300612679634764 1375 3372 An atypical antipsychotic.
SGTC_1332 1480-0653 17.5 µM 0.521542231655671 0.282245254434346 no 973 0.300994547026658 1427 5749438
SGTC_995 3931-2021 34.6 µM 0.520964113128069 0.282460550757208 no 974 0.301195885599805 1493 730143
SGTC_1626 st003712 1.76 µM 0.519744354532808 0.282915058303977 no 975 0.301620883999149 1478 24207035
SGTC_20 0481-0013 4.944 µM 0.517728543517128 0.283666960473436 no 976 0.302323840120688 1437 182045
SGTC_3108 9121785 49.47 µM 0.515542833277007 0.284483315455734 no 977 0.303086873067527 1532 17140271
SGTC_779 1360-0071 233 µM 0.514744597540304 0.284781733175323 no 978 0.303365752315942 1620 7566
SGTC_575 k072-0246 11.9 µM 0.510849160165454 0.286240168407973 no 979 0.304728341423811 1471 6796779
SGTC_513 4245-1575 41.7 µM 0.510719757441099 0.286288677046012 no 980 0.304773652002039 1516 719745
SGTC_2036 5160441 105 µM 0.509445973170211 0.286766383217888 no 981 0.305219829406919 1510 134534 YIL048W NEO1
SGTC_2190 6049624 200 µM 0.508575420403378 0.287093083056091 no 982 0.305524930713062 1482 2265554
SGTC_2282 7944268 200 µM 0.508567546011587 0.287096038951048 no 983 0.305527691056038 1544 2970414
SGTC_2337 9009472 200 µM 0.504735179003496 0.288536342921605 no 984 0.306872424540274 1570 5742383
SGTC_1047 2043-3044 82 µM 0.504176315762086 0.288746662493945 no 985 0.30706874109885 1417 669592
SGTC_2674 ligustilide 100 µM 0.504115392899208 0.288769594237633 no 986 0.307090145326718 1467 5319022 A signalling regulator.
SGTC_696 1560-0013 611 µM 0.502796147897851 0.289266376430556 no 987 0.307553801114179 1531 1650269
SGTC_1548 st061468 90.8 µM 0.502721601053838 0.28929446018873 no 988 0.30758001019456 1486 390799
SGTC_1233 0325-0408 14.2 µM 0.502340384486517 0.289438094530215 no 989 0.307714053161147 1548 12874
SGTC_560 2332-1943 155 µM 0.502329455302917 0.289442212909404 no 990 0.307717896447751 1494 21177716
SGTC_2226 7298446 200 µM 0.500178611346705 0.290253237846745 no 991 0.308474658671994 1530 3283010
SGTC_3136 9095672 49.47 µM 0.499959925626631 0.290335757884412 no 992 0.308551647664689 1439 17217380
SGTC_1913 st060213 96.1 µM 0.499591274790618 0.290474891424864 no 993 0.308681451401062 1552 688959
SGTC_2287 7945887 168.79 µM 0.498821111293487 0.290765661636847 no 994 0.308952706814735 1505 1245853
SGTC_2141 5621638 7.665 µM 0.494809452386739 0.292282433621456 no 995 0.310367315715738 1573 2856238
SGTC_3183 9108214 49.47 µM 0.493814066580091 0.292659349080314 no 996 0.31071874896307 1449 4974831
SGTC_1457 k015-0032 57.3 µM 0.493415165833283 0.292810461251814 no 997 0.310859634307313 1486 4302660
SGTC_569 4130-2812 160 µM 0.493318595480063 0.29284704962167 no 998 0.310893745576987 1476 743552
SGTC_1316 1272-0050 65.9 µM 0.492989787873797 0.292971643460024 no 999 0.311009901532396 1493 7340392
SGTC_2508 celastrol 40.54 µM 0.491173464857962 0.293660338754529 no 1000 0.311651882472294 1450 122724 Celastrol is a natural product and antioxidant.
SGTC_2618 avocadyne 43.43 µM 0.489790434153899 0.294185244601485 no 1001 0.312141100212738 1519 3015189
SGTC_1559 coumarin 343 70.1 µM 0.488432507580433 0.294701043967644 no 1002 0.312621760438872 1552 108770 A hepatotoxic, DNA x-linker.
SGTC_2875 9039966 71.43 µM 0.488353220929997 0.294731173356728 no 1003 0.312649835100373 1610 6463691
SGTC_885 0865-0106 16.8 µM 0.488316550383535 0.294745108858419 no 1004 0.31266282016563 1443 2793380
SGTC_1256 0570-0116 285 µM 0.486519570399646 0.295428367176334 no 1005 0.313299416610014 1466 410638
SGTC_3351 9150312 21.596 µM 0.486377802184521 0.295482302115721 no 1006 0.313349663001848 1487 4904905
SGTC_1950 st077106 7.18 µM 0.486195296758004 0.295551741970258 no 1007 0.313414352836145 1466 13831864
SGTC_1553 gossypol 38.6 µM 0.485991497789731 0.295629292479973 no 1008 0.313486597042027 1472 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_844 0330-0132 15.3 µM 0.484934338137128 0.296031717694545 no 1009 0.313861461804099 1551 2828079
SGTC_2553 4-methylesculetin 85.09 µM 0.484439776301486 0.296220067085122 no 1010 0.314036897553803 1466 5319502
SGTC_2671 danthron 100 µM 0.483844478931747 0.296446853565698 no 1011 0.314248122934295 1490 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1708 st033234 31.827 µM 0.483409467993082 0.296612627096312 no 1012 0.314402513435214 1567 674664
SGTC_1788 fluconazole 20 µM 0.482673247257671 0.296893282052839 no 1013 0.314663880803476 1476 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_41 0478-0632 82.643 µM 0.482300379030462 0.297035469617447 no 1014 0.314796289030457 1546 3750424
SGTC_1320 1313-0481 95.3 µM 0.482273278048748 0.297045805374058 no 1015 0.314805913715214 1559 6813365 YLR208W SEC13
SGTC_676 falcarinol 140 µM 0.480263012942722 0.297812937257555 no 1016 0.315520192763117 1619 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3208 9114115 49.47 µM 0.479275910405438 0.298189953285913 no 1017 0.315871178641183 1439 650895
SGTC_1118 chelidonine 707.474 nM 0.474580054389999 0.299986467757416 no 1018 0.317543162779126 1638 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3045 9092950 49.47 µM 0.473078587109885 0.300561922364234 no 1019 0.318078556486063 1634 44120432
SGTC_465 cgp-37157 41 µM 0.472551229972346 0.300764156265553 no 1020 0.318266691993662 1549 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2383 9036125 200 µM 0.471387365856219 0.301210698590777 no 1021 0.318682068268832 1552 79580
SGTC_73 0327-0325 16.231 µM 0.471096012164158 0.301322529628525 no 1022 0.318786086383666 1597 53298
SGTC_2823 7987624 58.44 µM 0.470721363501143 0.301466359459163 no 1023 0.318919863172262 1528 2239440
SGTC_2856 9022925 19.48 µM 0.469948103330805 0.301763316246191 no 1024 0.319196047813175 1540 4944862
SGTC_460 trequinsin 123 µM 0.469036417485151 0.302113601758389 no 1025 0.319521802763227 1540 5537 A vasodilator.
SGTC_3214 9129694 49.47 µM 0.468952552955559 0.302145833131776 no 1026 0.319551775443434 1630 17158655
SGTC_2752 diclazuril 33.15 µM 0.468570157214312 0.302292817566151 no 1027 0.319688456328439 1564 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3084 9116877 49.47 µM 0.467918469799678 0.302543385635537 no 1028 0.319921447393621 1518 27241325
SGTC_812 4251-0442 148 µM 0.466811565021136 0.302969193978949 no 1029 0.320317350424035 1532 5723007
SGTC_2243 6634756 200 µM 0.46607559015758 0.303252459953079 no 1030 0.320580697438464 1624 885676
SGTC_2684 capsaicin 100 µM 0.465917881630596 0.30331317506234 no 1031 0.320637140566652 1517 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_547 1120-0019 610 nM 0.465004003947534 0.303665109386087 no 1032 0.320964294639733 1550 3676939
SGTC_3297 9117502 71.43 µM 0.46387671804324 0.304099478126581 no 1033 0.321368037087373 1533 7453720
SGTC_135 0933-0004 26.348 µM 0.463646487180192 0.304188225321989 no 1034 0.321450521275089 1479 21230617 YGL099W LSG1
SGTC_110 0850-0284 111.64 µM 0.463603761175228 0.304204696203773 no 1035 0.321465829573929 1428 3906265
SGTC_3111 9122088 49.47 µM 0.463469819468917 0.304256333327845 no 1036 0.321513821508451 1580 16876704
SGTC_95 0471-0001 561.058 µM 0.462679223218257 0.304561202998396 no 1037 0.32179715648167 1451 4015405
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.461905228823207 0.304859802241767 no 1038 0.322074642078375 1630 1377
SGTC_1996 st072960 66.8 µM 0.461436804175587 0.305040578920333 no 1039 0.322242625727341 1551 1719405
SGTC_2918 7977171 22.06 µM 0.460727956986853 0.305314231096045 no 1040 0.322496897315899 1515 2236483
SGTC_2546 rhodinyl acetate 100 µM 0.46011222910932 0.305552022680192 no 1041 0.32271783335239 1622 6708682
SGTC_3151 9099821 49.47 µM 0.45831366591888 0.306247089989034 no 1042 0.323363553687622 1499 17174189
SGTC_59 0330-0160 1.33 µM 0.457038904367809 0.306740153322603 no 1043 0.323821541257441 1543 4293482
SGTC_1385 3091-4834 14.1 µM 0.456987086076055 0.306760203457547 no 1044 0.323840163826537 1596 4072814
SGTC_130 0136-0219 337.655 µM 0.456748784127271 0.306852417456455 no 1045 0.323925810969902 1592 234244
SGTC_1260 0700-1617 7.75 µM 0.45619566554054 0.307066500899117 no 1046 0.324124641018316 1569 2853078
SGTC_625 k213-0058 121 µM 0.455576142764279 0.307306364062321 no 1047 0.324347401014429 1614 3655420
SGTC_1488 4013-0813 75.9 µM 0.455107344605962 0.307487925368369 no 1048 0.324516007197433 1520 2910057
SGTC_3224 9130643 49.47 µM 0.454275189372146 0.307810327774797 no 1049 0.324815385611563 1603 17644395
SGTC_2724 maprotiline 69.64 µM 0.454239446024829 0.307824179168092 no 1050 0.324828247271322 1599 4011 A tricyclic antidepressant.
SGTC_1554 st069299 38.7 µM 0.454040082804808 0.307901442159021 no 1051 0.324899988700242 1553 24207999
SGTC_1492 4158-0558 28.5 µM 0.449724320004211 0.309576094324676 no 1052 0.326454616523376 1651 3967268
SGTC_262 fenpropimorph 62.5 µM 0.44905133835114 0.309837590331518 no 1053 0.326697311353038 1519 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2794 7785382 27.27 µM 0.448039958221851 0.31023075657412 no 1054 0.327062179473747 1613 2205081
SGTC_2839 9003951 25.97 µM 0.447939569802579 0.310269793645536 no 1055 0.327098404887389 1575 2990634
SGTC_2819 7996655 46.38 µM 0.442218159551093 0.312498144775313 no 1056 0.329165673236385 1628 6456960
SGTC_1520 flindersine 88 µM 0.440945698521002 0.312994674792212 no 1057 0.329626154531272 1730 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2584 androsterone 48.74 µM 0.440691584849298 0.313093873769288 no 1058 0.329718144783786 1577 2754130 A steroid.
SGTC_714 4296-0578 26.1 µM 0.439667019267594 0.313493973138553 no 1059 0.33008914643064 1647 1589775
SGTC_1238 0333-0287 48.8 µM 0.439015381864512 0.313748555939279 no 1060 0.330325195424421 1547 7226
SGTC_838 0109-0203 71.4 µM 0.438406542682952 0.313986498427329 no 1061 0.330545802231458 1570 759422
SGTC_1921 5740136 50 µM 0.438270322435987 0.314039745713885 no 1062 0.330595168344314 1703 1774243
SGTC_1100 amiodarone 5.07 µM 0.438019890850331 0.31413764730117 no 1063 0.33068593224795 1684 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_719 2810-4230 27.3 µM 0.437747850440343 0.314244011279499 no 1064 0.330784539118835 1600 721079
SGTC_1494 4358-1428 177 µM 0.436630345560001 0.31468110176118 no 1065 0.331189725825373 1700 1564571
SGTC_2048 5246248 200 µM 0.434893825055817 0.315360823650481 no 1066 0.331819748460424 1634 677046
SGTC_2797 7859098 81.82 µM 0.433000683435132 0.316102563935042 no 1067 0.332507136659705 1561 972681
SGTC_1603 st002045 67.8 µM 0.429809129157108 0.317354703490301 no 1068 0.333667245765489 1642 5887985
SGTC_989 1501-0895 10.3 µM 0.429361432813411 0.31753051551284 no 1069 0.333830108039923 1675 2830112
SGTC_1760 st045453 10.4495 µM 0.427591210747822 0.318226091195789 no 1070 0.33447438304374 1639 3323419 YIL048W NEO1
SGTC_2128 5255449 168.493 µM 0.427439878640892 0.318285584116185 no 1071 0.334529483252279 1540 736008
SGTC_2317 5986382 200 µM 0.426834028181211 0.318523807957384 no 1072 0.33475010984686 1718 877883
SGTC_1420 4'-methoxyflavone 42 µM 0.426395960513998 0.31869610540555 no 1073 0.334909672183843 1674 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2667 digitoxin 100 µM 0.426370291586598 0.318706202529349 no 1074 0.334919022792063 1625 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1503 4585-0012 61.3 µM 0.424554954966232 0.319420623942795 no 1075 0.335580568003265 1646 2922052
SGTC_2685 mycophenolic acid 18.85 µM 0.421956972578687 0.320444220423869 no 1076 0.33652821195037 1639 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1059 3448-6867 171 µM 0.42182634869262 0.320495721970181 no 1077 0.336575886002745 1652 3934407
SGTC_104 0074-0074 590.992 µM 0.421244791979213 0.320725056354905 no 1078 0.336788169754918 1607 3943124
SGTC_2516 gossypol 71.55 µM 0.419499102256106 0.321413872357316 no 1079 0.337425705335806 1723 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1220 1838-0075 193 µM 0.41938094562872 0.321460516951525 no 1080 0.337468873686094 1625 5529645
SGTC_1640 st009078 66.4 µM 0.416174175304512 0.32272752407723 no 1081 0.338641277718407 1670 690618
SGTC_2976 9009005 19.48 µM 0.414904794127658 0.323229631586803 no 1082 0.339105800070545 1749 2993148
SGTC_1948 st076329 66.6 µM 0.413042439714597 0.323966874382714 no 1083 0.33978776010049 1552 24208413
SGTC_1120 ficusin 1.78878 µM 0.412470099843206 0.324193583231714 no 1084 0.339997445976438 1701 6199 A DNA cross-linker.
SGTC_1122 capsaicin 818.572 nM 0.411417155625427 0.324610833952352 no 1085 0.340383338227583 1685 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_476 mead acid 10 µM 0.410233426137153 0.325080173968818 no 1086 0.340817361443276 1629 5312531 An omega 9 fatty acid.
SGTC_1893 st059353 36.1 µM 0.40811539300911 0.325920651097387 no 1087 0.341594479773308 1573 3112488
SGTC_965 1291-5240 308 µM 0.408001960377859 0.325965688406245 no 1088 0.341636117832272 1704 2834598
SGTC_2239 6685329 187.64 µM 0.407420496190482 0.326196592890895 no 1089 0.341849587898038 1593 805680
SGTC_2234 tolnaftate 200 µM 0.406610076060435 0.326518528931049 no 1090 0.342147197782005 1646 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3314 9135860 59.4275 µM 0.404486429016521 0.327362751545179 no 1091 0.34292752770667 1738 25252478
SGTC_2098 5376439 882.5 nM 0.402911874121234 0.327989262006435 no 1092 0.343506527883508 1737 2844116
SGTC_362 0310-0100 9.03 µM 0.402604125386396 0.328111770900943 no 1093 0.343619737160469 1613 790235
SGTC_2274 7947094 46.08 µM 0.402553955566834 0.328131744301475 no 1094 0.343638194095213 1572 2971028
SGTC_3287 9117173 37.0625 µM 0.402472160793315 0.328164309151237 no 1095 0.343668286308205 1623 2789709
SGTC_984 1492-0255 2.91 µM 0.401552627404591 0.328530491636765 no 1096 0.34400664982464 1659 1585198
SGTC_600 1495-0418 41.6 µM 0.400707096901372 0.328867349626089 no 1097 0.344317892558808 1630 5377768
SGTC_3238 9133470 49.47 µM 0.398989164806089 0.329552199081921 no 1098 0.344950594013877 1712 3534688
SGTC_2198 6589944 200 µM 0.39883709879442 0.329612847419559 no 1099 0.34500661970393 1671 5290268
SGTC_2266 7929956 200 µM 0.397588789754584 0.330110878546944 no 1100 0.345466662621418 1602 2967153
SGTC_2395 5646831 180.19 µM 0.397302285138695 0.330225226278271 no 1101 0.345572281236363 1686 6808628
SGTC_3343 9148379 18.9835 µM 0.397208348790192 0.330262720953508 no 1102 0.345606913058779 1773 1955036
SGTC_2935 9038016 29.96 µM 0.396478350700352 0.330554157614089 no 1103 0.345876087875135 1679 6463195
SGTC_115 0527-0192 112.043 µM 0.395706997033711 0.330862216312529 no 1104 0.346160596543744 1633 4233931
SGTC_2430 5571206 200 µM 0.394928151271873 0.331173383411643 no 1105 0.346447956744705 1778 1731771
SGTC_2158 5657123 3.6195 µM 0.394613820140854 0.33129899909435 no 1106 0.346563956303241 1653 2858827
SGTC_427 1354-0053 47.3 µM 0.392554359342482 0.332122487460155 no 1107 0.347324327384367 1725 6813657
SGTC_1883 5-benzylidenerhodanine 20 µM 0.389849324778273 0.333205344968749 no 1108 0.348323983901438 1744 1273210
SGTC_1042 0350-0096 82 µM 0.389447563829187 0.333366293587016 no 1109 0.348472546404205 1593 3122515
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.388778006817074 0.333634591598231 no 1110 0.348720185738105 1715 140250 A respiratory chain inhibitor.
SGTC_392 N-ethylmaleimide 8.33 µM 0.387805329618133 0.334024504407382 no 1111 0.349080050569327 1628 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1378 2093-0007 380 nM 0.387241135668649 0.334250752502093 no 1112 0.349288849639343 1651 3618014
SGTC_2446 5162541 200 µM 0.386878987213367 0.334396009835097 no 1113 0.349422898979431 1606 1549321
SGTC_3070 9117005 49.47 µM 0.385579406133319 0.334917474361115 no 1114 0.349904093769045 1714 8779016
SGTC_256 clotrimazole 625 nM 0.385312451514244 0.335024630924279 no 1115 0.350002968713092 1649 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_537 1334-0398 209 µM 0.383316935439977 0.335826063306454 no 1116 0.350742391906054 1770 5846986
SGTC_724 3910-0327 137 µM 0.383047573335723 0.335934300913368 no 1117 0.350842245368032 1603 2885483
SGTC_860 0443-0016 25.1 µM 0.380886668283894 0.336803107864744 no 1118 0.351643672680308 1670 5337942
SGTC_2969 9091408 28.7 µM 0.379921042897584 0.33719162634144 no 1119 0.352002013250309 1578 4286311
SGTC_1652 st011932 78 µM 0.379901318574305 0.337199564216221 no 1120 0.352009334256472 1741 1551076
SGTC_1365 1672-3266 55.4 µM 0.379225691262924 0.33747150803148 no 1121 0.35226013752294 1745 6415873
SGTC_289 k017-0060 526 µM 0.377911492686316 0.338000723506185 no 1122 0.35274817228015 1650 5512909
SGTC_165 k038-0023 64.381 µM 0.376687333018732 0.338493969366146 no 1123 0.353202988712296 1620 46368543
SGTC_1731 st035964 63 µM 0.376099562743457 0.338730895896977 no 1124 0.35342143968844 1634 6739575
SGTC_98 0074-0023 107.663 µM 0.375741183622919 0.338875387613736 no 1125 0.353554658745739 1596 3563821
SGTC_223 busulfan 5 mM 0.375536884540925 0.338957767770996 no 1126 0.353630610181412 1715 2478 A DNA alkylator.
SGTC_831 k061-1017 217 µM 0.375443520883665 0.338995417654613 no 1127 0.353665321547326 1751 1240153
SGTC_678 1218-2179 85.9 µM 0.374939618620933 0.339198649333429 no 1128 0.353852686704849 1699 6820081 YOR116C RPO31
SGTC_2115 tiliquinol 12.7705 µM 0.374712967027007 0.339290076733399 no 1129 0.353936973743452 1681 71208 A bioactive hydroxyquinoline.
SGTC_326 k292-0812 17.5 µM 0.374078793975248 0.339545941624209 no 1130 0.354172847606661 1777 3579357
SGTC_2992 9074591 71.4286 µM 0.372679629265521 0.340110713279784 no 1131 0.354693449734794 1673 17741321
SGTC_2251 lansoprazole 556 µM 0.371874400203024 0.340435906128639 no 1132 0.354993183053689 1613 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2747 doxorubicin 7.63 µM 0.371068583310221 0.340761455187185 no 1133 0.35529322504786 1735 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_658 3253-0951 102 µM 0.370076823152439 0.341162287947432 no 1134 0.35566262526991 1683 1184878
SGTC_2055 5235184 200 µM 0.369535817268464 0.341381018122356 no 1135 0.355864190540796 1690 2836034
SGTC_2568 diosmetin 100 µM 0.368065392016178 0.341975784207729 no 1136 0.356412237716982 1753 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1044 1222-0021 1.78 µM 0.367204554124743 0.342324163072386 no 1137 0.356733221278207 1721 4306703
SGTC_3319 9138450 16.7555 µM 0.365837220581142 0.342877795234614 no 1138 0.357243272126187 1668 2029690
SGTC_1516 st013856 110 µM 0.36443680772018 0.343445171120926 no 1139 0.357765926947792 1672 5281404 A mutagen and neurotoxin.
SGTC_1128 3448-9350 235 µM 0.364385047269881 0.34346614858783 no 1140 0.357785249832981 1660 619386
SGTC_1257 0669-0121 16 µM 0.363575290143408 0.343794389564988 no 1141 0.358087590682078 1787 4307855
SGTC_84 0443-0269 128.823 µM 0.363054652996857 0.344005495870163 no 1142 0.358282029181763 1691 6150058
SGTC_741 4582-0002 126 µM 0.360612209827433 0.344996498313557 no 1143 0.359194680272826 1646 2912688
SGTC_2782 7736369 71.43 µM 0.359716214266007 0.345360308747272 no 1144 0.359529682696639 1665 2950836 YOL077C BRX1
SGTC_259 usnic acid 108.925 µM 0.359675681956027 0.345376769885793 no 1145 0.359544839815487 1745 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_93 0109-0045 59.227 µM 0.358973593315384 0.345661951226633 no 1146 0.359807421973528 1738 88733
SGTC_1795 st049545 62.3 µM 0.357075016754133 0.346433572298589 no 1147 0.360517823500017 1822 5291882
SGTC_630 4356-0227 183 µM 0.357074504114053 0.346433780732458 no 1148 0.360518015382722 1692 779312
SGTC_1756 st041558 35.5 µM 0.356943591036304 0.346487010085234 no 1149 0.360567017686383 1852 3955792
SGTC_2433 5607874 27.82 µM 0.35577962986038 0.346960410741687 no 1150 0.361002802638478 1636 2252428
SGTC_511 blebbistatin 171 µM 0.355359280225549 0.347131432084801 no 1151 0.361160225169469 1787 3476986 A myosin inhibitor.
SGTC_1198 1612-1005 86.7 µM 0.353308891590712 0.347966088725808 no 1152 0.36192844015537 1793 6998509
SGTC_868 0527-0199 213 µM 0.353098057720251 0.348051955241958 no 1153 0.362007464470968 1693 2849450
SGTC_3177 9107506 49.47 µM 0.352556585431501 0.348272516880926 no 1154 0.362210444944888 1795 8897194
SGTC_1105 epirubicin 18.1 µM 0.351287263852609 0.34878975945137 no 1155 0.362686424420257 1654 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_661 1304-0007 33.6 µM 0.351153731603572 0.348844189575758 no 1156 0.362736509670661 1674 3117130
SGTC_1653 st012112 65 µM 0.35112299013256 0.348856720787753 no 1157 0.362748040508329 1767 720429
SGTC_1241 0364-0022 50.8 µM 0.350957928202301 0.348924008156503 no 1158 0.362809955819485 1736 4563895
SGTC_974 1326-0144 138 µM 0.350900057828147 0.348947600094939 no 1159 0.36283166404986 1672 5411856
SGTC_3105 9121040 49.47 µM 0.349775114237211 0.349406320254225 no 1160 0.363253738356422 1739 41448907
SGTC_1033 k072-0102 21.3 µM 0.349394081236629 0.349561744648676 no 1161 0.363396738087985 1806 5965931
SGTC_106 0092-0003 11.579 µM 0.34862906086411 0.349873874667748 no 1162 0.363683903779416 1827 1072148
SGTC_373 0844-0104 25.9 µM 0.346737681368209 0.350645996938015 no 1163 0.364394199368682 1822 5375804
SGTC_1401 3807-4679 7.6 µM 0.34624559428824 0.35084698413395 no 1164 0.364579076032931 1694 3291456
SGTC_3069 9117009 49.47 µM 0.345286455699412 0.351238852976681 no 1165 0.364939514026006 1753 41904981
SGTC_978 1416-0512 87.4 µM 0.344532800946302 0.351546879688463 no 1166 0.365222816317708 1732 6814003
SGTC_3288 9119690 36.221 µM 0.34398550840979 0.351770625093245 no 1167 0.365428592222148 1657 17595618 YKL019W RAM2
SGTC_1813 st051246 8.6015 µM 0.341117849615298 0.352943825851832 no 1168 0.366507432107734 1832 5291959
SGTC_1660 st012960 28.1 µM 0.340101380150517 0.353360014776319 no 1169 0.366890091227792 1727 24207266
SGTC_700 3453-2283 142 µM 0.340087642023615 0.353365640994098 no 1170 0.366895263976859 1784 565664
SGTC_1207 2099-0101 141 µM 0.339917186674258 0.353435450767653 no 1171 0.36695944669757 1839 5837381
SGTC_3107 9121808 49.47 µM 0.338720107677724 0.353925851752143 no 1172 0.367410295728545 1823 662681
SGTC_227 fluconazole 33.516 µM 0.338709243527716 0.353930303521994 no 1173 0.367414388269468 1681 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1343 1487-0095 224 µM 0.338238182350232 0.354123348031425 no 1174 0.367591852169036 1839 4560101 YGL055W OLE1
SGTC_439 amiodarone 34.4 µM 0.337884856041812 0.354268168495944 no 1175 0.367724980117355 1784 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1428 4049-0204 61.7 µM 0.337348028035952 0.354488242491262 no 1176 0.367927279113379 1810 X1428
SGTC_875 0709-0210 25.7 µM 0.33730021710355 0.354507845061078 no 1177 0.36794529802784 1828 6251364
SGTC_1725 st036284 20.55 µM 0.335819710245136 0.355115046082803 no 1178 0.368503412931247 1870 707914
SGTC_447 ml7 120 µM 0.335636235390083 0.355190320383557 no 1179 0.368572597819305 1791 4216 Selective myosin light chain kinase inhibitor.
SGTC_3249 9135183 49.47 µM 0.334447100431243 0.355678324135853 no 1180 0.369021101259222 1770 4902779
SGTC_1833 st055984 71 µM 0.334362750598543 0.355712949082101 no 1181 0.36905292208471 1735 676288
SGTC_1087 pterostilbene 9.05 µM 0.333066273636122 0.35624529234928 no 1182 0.369542128517103 1838 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.333021274303092 0.356263774455455 no 1183 0.36955911214911 1740 4213774
SGTC_841 0251-0215 91.2 µM 0.332765003304947 0.356369036402482 no 1184 0.369655838707742 1769 3888614
SGTC_2150 5556613 200 µM 0.330062497871442 0.357479740934899 no 1185 0.370676369564735 1763 743190
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.326038834819713 0.359135665493437 no 1186 0.372197486574174 1827 77254
SGTC_2064 5220758 200 µM 0.325994986723731 0.359153725676993 no 1187 0.372214074071698 1745 788518
SGTC_81 0411-0046 9.971 µM 0.325331333202991 0.359427110152017 no 1188 0.372465159544608 1723 12925265
SGTC_2540 epiandrosterone 100 µM 0.325220724352921 0.359472681203367 no 1189 0.372507012370689 1736 441302 A steroid.
SGTC_1496 4469-0713 57.4 µM 0.325159140956995 0.359498054542934 no 1190 0.372530315310111 1846 746691
SGTC_2642 cholecalciferol 100 µM 0.323489918797535 0.360186036268156 no 1191 0.373162120553018 1802 9821465 A vitamin D precursor, similar to steriods.
SGTC_1675 st018485 24.5 µM 0.322943575980989 0.360411313844773 no 1192 0.373368987035007 1731 3323024
SGTC_118 0083-0097 135.343 µM 0.321915664201665 0.360835291637835 no 1193 0.373758293017554 1742 5207356
SGTC_1139 k015-0024 46.9 µM 0.321736745618128 0.360909106814884 no 1194 0.373826068890429 1871 2766652
SGTC_2987 9018338 71.43 µM 0.321629999039765 0.360953148965078 no 1195 0.373866507255675 1744 5055682
SGTC_3232 9132874 49.47 µM 0.321402277613552 0.361047109812352 no 1196 0.373952778662339 1698 3784940
SGTC_1209 2323-2347 50.3 µM 0.319694521025385 0.361752019464108 no 1197 0.374599956790764 1880 5412760
SGTC_3223 9129970 49.47 µM 0.318349427019787 0.362307563681353 no 1198 0.375109947787119 1760 17248386
SGTC_3121 9125696 49.47 µM 0.317713710545246 0.362570225257287 no 1199 0.375351055091668 1829 1235365
SGTC_3261 9137475 49.47 µM 0.316886613618615 0.362912057103247 no 1200 0.375664819883804 1772 17027690
SGTC_3188 9110789 49.47 µM 0.316622807360094 0.363021108891937 no 1201 0.375764913874886 1842 849217
SGTC_3091 9116372 49.47 µM 0.316187832701715 0.363200942239081 no 1202 0.375929971238083 1790 17169793
SGTC_1422 4031-0024 15.5 µM 0.315816446837953 0.363354509682841 no 1203 0.376070916890415 1845 782427
SGTC_2746 daunorubicin 9.88 µM 0.315196466110898 0.363610919622323 no 1204 0.376306244277813 1870 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_122 0236-0016 402.397 µM 0.314223545937913 0.364013420444357 no 1205 0.376675630317054 1762 6808838
SGTC_2379 9035213 200 µM 0.313857068450616 0.364165072526256 no 1206 0.376814799160596 1898 646551
SGTC_3189 9110682 49.47 µM 0.313517585279022 0.36430557306794 no 1207 0.376943731268501 1749 17122418
SGTC_1655 st012546 55.1 µM 0.313099302857214 0.364478711015342 no 1208 0.377102609365765 1777 720985 YLR208W SEC13
SGTC_505 gw-5074 63.9 µM 0.312612395372326 0.364680289484679 no 1209 0.377287579837913 1838 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3026 9090633 49.47 µM 0.310665357483134 0.365486731733942 no 1210 0.378027517835028 1729 25236842
SGTC_58 0957-0393 9 µM 0.308288316943539 0.36647208287331 no 1211 0.378931477571124 1751 6997992
SGTC_1842 st055362 61.2 µM 0.308009209658158 0.366587838717999 no 1212 0.379037662254813 1822 676032
SGTC_492 tmb-8 126 µM 0.307735585240517 0.366701332401123 no 1213 0.379141769876183 1875 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2188 6126565 140.678 µM 0.306803376269078 0.367088080616001 no 1214 0.379496519116628 1852 874518
SGTC_3099 9120367 49.47 µM 0.306338737606823 0.367280896998354 no 1215 0.379673373833211 1760 24824940
SGTC_1702 st027038 51 µM 0.306251738098203 0.36731700389437 no 1216 0.379706491124808 1789 5521182
SGTC_2041 5107442 45.335 µM 0.305737313351965 0.367530526550137 no 1217 0.379902330422009 1872 793005
SGTC_1885 st057546 99.9 µM 0.30563578890404 0.36757267121844 no 1218 0.379940983985446 1867 702008
SGTC_2049 5262831 67.185 µM 0.303800754218059 0.368334702394717 no 1219 0.380639846049676 1758 763417
SGTC_3005 9076496 71.4286 µM 0.300761160155989 0.369598087467795 no 1220 0.381798313771843 1868 21368410
SGTC_755 1995-0008 37.3 µM 0.299792801216279 0.370000875429345 no 1221 0.382167603358046 1814 689533
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.299649961112472 0.370060301714137 no 1222 0.382222085384765 1841 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1345 1488-0192 31.4 µM 0.299172747632308 0.370258861052333 no 1223 0.382404120901854 1882 658348
SGTC_865 0488-0499 301 µM 0.298429689468696 0.370568102063995 no 1224 0.382687615958321 1923 9634651
SGTC_2916 7875993 68.79 µM 0.298209319762363 0.370659830156182 no 1225 0.382771704542841 1947 1299250
SGTC_524 r073-0010 27.8 µM 0.297614383830686 0.370907506789531 no 1226 0.382998747545719 1740 2772106
SGTC_3219 9131112 49.47 µM 0.297435091351302 0.370982158191044 no 1227 0.383067178099408 1821 17612988 YMR079W SEC14
SGTC_983 1491-0821 12.2 µM 0.295149686854542 0.371934148856637 no 1228 0.383939767390906 1891 46495113
SGTC_3030 9087619 49.47 µM 0.294292652472878 0.372291350873843 no 1229 0.384267143336536 1745 25236973
SGTC_500 h-89 112 µM 0.293694189540708 0.372540848490577 no 1230 0.384495797343842 1914 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3310 9130229 44.1445 µM 0.289456298632428 0.374309139098458 no 1231 0.386116108882882 1883 7761258
SGTC_878 0828-0289 13.7 µM 0.288927842891852 0.374529827473926 no 1232 0.386318298202776 1765 745350 YLR208W SEC13
SGTC_2374 9071832 200 µM 0.288727886823767 0.374613341841298 no 1233 0.38639481026315 1847 17381698
SGTC_1108 betulinic acid 729.144 nM 0.288477708926799 0.37471784032055 no 1234 0.38649054564339 1776 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_684 1140-0066 328 µM 0.288345082249527 0.374773241776553 no 1235 0.386541300593036 1778 6813534
SGTC_397 arbidol 50 µM 0.288157609996686 0.374851557999803 no 1236 0.386613047726046 1897 131410 A RNA synthesis inhibitor.
SGTC_590 k048-0076 22.4 µM 0.287458345822083 0.375143719955943 no 1237 0.386880695900204 1903 6832814
SGTC_1491 4138-0063 26.5 µM 0.287215604807821 0.375245157170652 no 1238 0.38697361928051 1916 23883227
SGTC_1578 josamycin 24.2 µM 0.287054403084782 0.375312525312585 no 1239 0.387035332288148 1739 5282165 A P450 substrate.
SGTC_2851 9015922 71.43 µM 0.286614503160275 0.375496384133824 no 1240 0.387203754116321 1890 2996893
SGTC_3278 9139605 49.47 µM 0.285577476315874 0.37592992759775 no 1241 0.387600878310111 1894 7958859
SGTC_1434 4073-0095 163 µM 0.285347212957969 0.376026213662824 no 1242 0.387689072472778 1885 24133745
SGTC_3273 9137859 49.47 µM 0.284890411335766 0.376217250960147 no 1243 0.387864051181112 1893 2377234
SGTC_1776 st049249 45.9 µM 0.283905083750283 0.37662942434307 no 1244 0.388241560234236 1748 1822314
SGTC_2552 juarezic acid 87.02 µM 0.283711746954655 0.376710315779233 no 1245 0.388315645863777 1849 1549512
SGTC_2717 st081029 62.2815 µM 0.282928070400133 0.377038258704846 no 1246 0.388615988137029 1936 5292846
SGTC_3159 9100096 49.47 µM 0.282825557717102 0.377081163465907 no 1247 0.388655280821204 1793 25236875
SGTC_3110 9122132 49.47 µM 0.282098811536312 0.377385372939479 no 1248 0.388933872247855 1917 918317
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.279814206258952 0.378342183153268 no 1249 0.389810025945789 1819 65057 A dermal irritant. YDR527W RBA50
SGTC_1608 st001473 40.5 µM 0.279482808909867 0.378481037035333 no 1250 0.389937164557809 1752 7292267
SGTC_3039 9090270 49.47 µM 0.279299463377881 0.378557864667402 no 1251 0.390007509035826 1947 17173750
SGTC_1487 3970-0795 2.82 µM 0.278931019450205 0.378712268950096 no 1252 0.390148881406911 1857 3765103
SGTC_2608 thymoquinone 42.66 µM 0.278312719850861 0.378971424075724 no 1253 0.390386156336092 1870 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2741 miltefosine 3.04 µM 0.278060664097582 0.379077086764306 no 1254 0.390482895454347 1840 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2136 5328288 199.296 µM 0.277768111750333 0.379199737102127 no 1255 0.390595185686229 1777 262395
SGTC_2165 5727197 32.143 µM 0.27703693891478 0.379506328884758 no 1256 0.390875871301083 1854 1361712
SGTC_152 4469-0003 551.229 µM 0.276158012203876 0.379874976379578 no 1257 0.391213352523582 1961 697280
SGTC_2322 7413319 38.22 µM 0.275618464524116 0.38010133252113 no 1258 0.391420563079374 1822 1840400
SGTC_2529 gangaleoidin 93.61 µM 0.273568397270694 0.380961770033853 no 1259 0.392208161551522 1824 4565183
SGTC_3046 9092212 49.47 µM 0.272048079116845 0.381600246176757 no 1260 0.392792525573486 1822 25236637
SGTC_1808 st050063 61.5 µM 0.270790189549631 0.382128755968755 no 1261 0.393276202840919 1914 4011993
SGTC_245 methotrexate 289.6 µM 0.270598878306957 0.382209155799364 no 1262 0.393349779316149 1878 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2521 angolensin 13.4 µM 0.268469959897933 0.383104190018923 no 1263 0.394168797454596 1861 821428 A flavenoid.
SGTC_2617 dihydrotanshinone i 20.83 µM 0.267175290890056 0.383648796969987 no 1264 0.394667099929375 1795 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1410 3909-8106 77.9 µM 0.266225703574535 0.384048390358647 no 1265 0.395032694262693 1925 1039210
SGTC_3252 9135871 49.47 µM 0.265223531880226 0.384470245367291 no 1266 0.395418634009236 1902 17682838
SGTC_1347 1493-0251 600 nM 0.264510764300581 0.384770361674505 no 1267 0.39569318569562 1930 3986378
SGTC_1739 st037196 92.5 µM 0.263568251791902 0.385167319875313 no 1268 0.396056312534814 1970 612214
SGTC_2788 5282734 71.43 µM 0.261514446091624 0.386032738058743 no 1269 0.39684790533106 1942 743706
SGTC_2013 4024628 200 µM 0.260061341649113 0.386645380007365 no 1270 0.397408228533014 1892 5230760
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.259919070517154 0.386705378014891 no 1271 0.397463100282207 1945 165506
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.259705204702631 0.386795573737554 no 1272 0.397545588797494 1843 16623 A steroid.
SGTC_764 1951-2361 146 µM 0.259134320386995 0.387036368299719 no 1273 0.397765802563239 1773 5438930
SGTC_1928 4'-methoxychalcone 40.3 µM 0.258856352351242 0.387153628800069 no 1274 0.397873038164996 2026 641818
SGTC_1941 st076221 61.8 µM 0.256978363176473 0.387946125727506 no 1275 0.398597737996361 1985 2828568
SGTC_508 roscovitine 141 µM 0.256896021038724 0.387980884182683 no 1276 0.398629521140306 1889 160355 A CDKinase inhibitor.
SGTC_1607 st000305 50.6 µM 0.256594336926842 0.388108239449025 no 1277 0.398745973574866 1941 5457690
SGTC_120 rhodamine 6G 52.259 µM 0.254928435466546 0.388811712338283 no 1278 0.39938918667764 1910 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_3125 9127534 49.47 µM 0.25411838367002 0.389153911020746 no 1279 0.399702050664764 1971 1639235
SGTC_18 0111-0177 500 nM 0.252639524129878 0.389778862810743 no 1280 0.400273392346831 1863 721752
SGTC_845 0330-0138 4.51 µM 0.25088117761849 0.39052229398075 no 1281 0.400952988597814 1969 9039800
SGTC_2437 5741531 144.16 µM 0.250873409800013 0.390525579114771 no 1282 0.40095599150572 1981 2262990
SGTC_475 α-linolenic acid 10 µM 0.250330946745772 0.390755014688131 no 1283 0.401165713058081 1954 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3101 9120531 49.47 µM 0.249822820256454 0.390969962063288 no 1284 0.40136218559183 1965 24824904
SGTC_2927 9011802 47.9 µM 0.248204177125072 0.391654901327014 no 1285 0.401988217290817 1780 43912568
SGTC_3301 9125354 19.7965 µM 0.246986360887677 0.39217044973362 no 1286 0.402459389788762 1828 41905162
SGTC_1013 4112-3890 241 µM 0.245936698794532 0.392614964001538 no 1287 0.402865617292272 1841 705171
SGTC_1121 fusaric acid 630.51 nM 0.245657751634264 0.392733117028384 no 1288 0.402973589698862 1820 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_939 1165-0479 45.3 µM 0.245380343680677 0.392850627900712 no 1289 0.403080973660912 2001 1377347
SGTC_2031 5180455 200 µM 0.244970936147805 0.393024072045609 no 1290 0.403239467700244 1865 29949
SGTC_2044 5102272 200 µM 0.243242011833487 0.393756758952511 no 1291 0.403908961614308 1875 592666
SGTC_872 0588-0139 234 µM 0.242726068600409 0.393975479396254 no 1292 0.404108805717883 1851 2047100
SGTC_291 SEC14.278 35.5 µM 0.242311865338008 0.394151094085893 no 1293 0.40426926024154 1964 1068044
SGTC_3093 9117344 49.47 µM 0.241851487156689 0.394346311359412 no 1294 0.404447620954046 1895 24824913
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.241849801634691 0.394347026131496 no 1295 0.404448273999141 1865 115019
SGTC_1716 st033144 30.6155 µM 0.240201989349708 0.395045976651372 no 1296 0.405086835772437 1993 674617
SGTC_1383 3049-0032 20.7 µM 0.23895991093054 0.395573050985886 no 1297 0.405568334356376 1992 712864
SGTC_423 5-fluorouracil 457 µM 0.237491438009981 0.396196441929351 no 1298 0.406137780355206 1750 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2411 st077133 39.94 µM 0.235845566635499 0.396895456963196 no 1299 0.406776254131695 2029 1403142 YNL221C POP1
SGTC_305 1682-2595 20.8 µM 0.235577742688494 0.39700923539479 no 1300 0.406880173087307 1919 226033
SGTC_182 3448-4371 550.524 µM 0.234799790382857 0.397339779025494 no 1301 0.407182065221948 2080 3491403
SGTC_52 0329-0193 875 nM 0.234399978947799 0.397509683338876 no 1302 0.407337237493819 1972 3739292
SGTC_766 1391-0721 126 µM 0.233858089225222 0.397739996434194 no 1303 0.407547575495745 1984 1020919 YIL115C NUP159
SGTC_934 2950-0684 338 µM 0.233803047846173 0.39776339202783 no 1304 0.407568941655445 2005 1121253
SGTC_2101 5377231 179.231 µM 0.233503788159891 0.397890600178603 no 1305 0.407685114162457 1964 2844213
SGTC_1927 st060202 13.8 µM 0.233185330875735 0.398025980693141 no 1306 0.407808748086212 2018 688887
SGTC_1806 st050005 60.3 µM 0.233097289735713 0.398063410344051 no 1307 0.407842929711818 1844 5194765
SGTC_2973 9094665 17.96 µM 0.232977864291434 0.398114184160548 no 1308 0.407889297290954 1996 25237061 YIL048W NEO1
SGTC_1490 4089-0339 670 nM 0.231755557895945 0.398633947685109 no 1309 0.408363938469417 1997 742542
SGTC_769 0302-0231 76 µM 0.231396762058066 0.398786553263111 no 1310 0.408503290208357 1914 571869 YER009W NTF2
SGTC_1138 3761-0006 1.03 µM 0.231215292475771 0.398863743080706 no 1311 0.408573775092349 1981 12061087
SGTC_275 trichlorophene 5.69 µM 0.2301019987142 0.39933737966634 no 1312 0.409006255906774 1909 62616
SGTC_1415 3966-0071 78.1 µM 0.229662522656763 0.399524389970775 no 1313 0.409177009539118 1928 2893185
SGTC_3345 9148410 3.559 µM 0.227608828891425 0.400398603484768 no 1314 0.409975177818511 1997 4903596
SGTC_2534 helenine 20.12 µM 0.226295283240141 0.400958013833828 no 1315 0.410485883339743 1868 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1804 st050076 49.1 µM 0.226137890225198 0.401025057725844 no 1316 0.410547087823511 1954 3895976
SGTC_3196 9111891 49.47 µM 0.225761296602667 0.401185485199271 no 1317 0.410693540380591 1983 18891510
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.22488942393364 0.40155696358913 no 1318 0.411032648525904 1949 88881 An O-methylated flavonoid and antioxidant.
SGTC_402 epigallocatechin gallate 10 µM 0.224672024874919 0.401649604579605 no 1319 0.411117214579035 1873 65064 An antioxidant.
SGTC_2995 9067767 71.4286 µM 0.223777071997943 0.402031032012197 no 1320 0.411465385731572 1918 11673567
SGTC_1458 k015-0034 6.33 µM 0.220076126462067 0.403609355952882 no 1321 0.412905933669573 1827 3598957
SGTC_908 3448-7491 47.7 µM 0.219337087012389 0.403924719457333 no 1322 0.413193736966686 1893 1203031
SGTC_1080 nisoldipine 24.4 µM 0.218235125055962 0.404395065485565 no 1323 0.413622959369186 1904 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2261 9010538 184.68 µM 0.218045515642528 0.404476009670882 no 1324 0.413696824073758 1862 6457250
SGTC_188 3229-0966 278.469 µM 0.217599638767904 0.404666370443028 no 1325 0.413870532984124 2030 5722370
SGTC_2563 tomatine 8.54 µM 0.217531207062045 0.404695588382425 no 1326 0.413897194745033 2144 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_541 4513-1321 94 µM 0.217362630923634 0.4047675667504 no 1327 0.413962875594082 1857 747515
SGTC_3262 9137218 49.47 µM 0.216307943106192 0.405217968712236 no 1328 0.414373858961974 1960 17650664
SGTC_608 k048-0125 159 µM 0.215796973742406 0.40543622217018 no 1329 0.414573003674483 2020 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2304 7443016 91.4 µM 0.21527045119539 0.405661149716557 no 1330 0.414778233042116 1914 939854
SGTC_3242 9133940 49.47 µM 0.214204606385807 0.40611656806452 no 1331 0.415193752037687 1988 17248444
SGTC_2777 climbazole 1.536 µM 0.213536227673549 0.406402220403176 no 1332 0.415454367531889 1999 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1236 0330-0013 258 µM 0.213505330455567 0.406415426491908 no 1333 0.415466415934071 1905 4617066
SGTC_814 3342-0569 96 µM 0.211300794284641 0.407357963220523 no 1334 0.416326281583467 1968 4346283
SGTC_756 0508-1999 28.3 µM 0.210932434717863 0.407515505701309 no 1335 0.416469997118366 1827 6753853
SGTC_2091 4-phenylthiadiazole 200 µM 0.210702229729887 0.40761396890599 no 1336 0.416559817296866 1912 270010
SGTC_3048 9093155 49.47 µM 0.209417198140606 0.408163709266869 no 1337 0.417061284114732 2055 25236002
SGTC_959 1222-0044 107 µM 0.209153746552001 0.408276437015443 no 1338 0.417164109358643 2088 6083612
SGTC_2078 5212016 200 µM 0.20839694641068 0.408600304837534 no 1339 0.417459520201705 2085 1899708
SGTC_2975 9084847 53.72 µM 0.208181187025215 0.408692649144353 no 1340 0.417543748683519 1880 27211724
SGTC_3227 9130768 49.47 µM 0.205886763588385 0.409674967431935 no 1341 0.41843968253926 1984 17720899
SGTC_2641 levomentholum 100 µM 0.205302781375499 0.409925080273507 no 1342 0.418667785560154 2010 16666
SGTC_2820 7989630 71.43 µM 0.205298459887641 0.409926931253625 no 1343 0.418669473632153 2081 2984098
SGTC_1690 st023502 41.2 µM 0.203863452730183 0.410541684415729 no 1344 0.419230102883885 2046 24207482
SGTC_142 0335-0849 62.6745 µM 0.20328519243393 0.41078947178523 no 1345 0.419456064310921 1966 3889043 YPR107C YTH1
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.202516280338739 0.41111900951903 no 1346 0.419756566110084 2050 688662
SGTC_1407 3909-7909 12.3 µM 0.202483681213805 0.411132982129008 no 1347 0.41976930734772 1951 4411780
SGTC_3191 9110352 49.47 µM 0.200562574532389 0.411956603790597 no 1348 0.420520312287443 1983 17122424
SGTC_1056 3448-1962 115 µM 0.20008569873687 0.412161111425093 no 1349 0.420706778983193 1965 715507
SGTC_90 0870-0863 4.608 µM 0.199595493993171 0.412371360028319 no 1350 0.420898476073836 1905 1738164
SGTC_2566 crystal violet carbinol 226 nM 0.199445284305214 0.412435789935328 no 1351 0.420957220102651 1790 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2000 st075254 36.4 µM 0.198188341697649 0.41297502655187 no 1352 0.421448854276231 1939 17234175
SGTC_1147 3809-1045 12.3 µM 0.197622451545327 0.413217850814319 no 1353 0.421670233718622 1926 325925
SGTC_1476 4112-3294 3.34 µM 0.195905376032269 0.413954853181639 no 1354 0.422342114670173 2036 704369
SGTC_2842 9000675 19.48 µM 0.195576149230824 0.414096198474125 no 1355 0.422470964951276 1843 2989072
SGTC_1564 D-Arginine 115 µM 0.195363887110195 0.414187333807629 no 1356 0.422554042885184 1861 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_682 0kpi-0099 17 µM 0.195039714290898 0.414326527227592 no 1357 0.422680928544117 1925 1714895 YML126C ERG13
SGTC_758 0868-0029 16 µM 0.194362442111446 0.414617369260345 no 1358 0.422946047979284 2081 762687
SGTC_2621 lithochol-11-enic acid 100 µM 0.192387849101107 0.415465588425217 no 1359 0.423719204816593 2094 6708711
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.191973910796582 0.415643452583818 no 1360 0.423881320739762 1875 23665772 A membrane-active detergent.
SGTC_2499 avocadenofuran 51.48 µM 0.191656403406859 0.415779893288912 no 1361 0.424005678929478 1862 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1830 st055982 50.3 µM 0.191543611898902 0.415828365008453 no 1362 0.424049857826714 2098 455313 An antimicrobial agent.
SGTC_1367 1812-0510 76.9 µM 0.191516572298303 0.415839985363808 no 1363 0.424060449011795 2018 1142582 YDR527W RBA50
SGTC_1045 1348-1485 165 µM 0.191009360315364 0.41605797497106 no 1364 0.424259129852929 2070 6810614
SGTC_3065 9113888 49.47 µM 0.19073908905608 0.416174142726872 no 1365 0.424365006117586 2022 16648368
SGTC_1597 7-benzyloxygramine 47.5 µM 0.1906339587124 0.41621933173801 no 1366 0.424406191431723 1917 260807
SGTC_1000 4048-0884 8.67 µM 0.189991109949252 0.416495676600828 no 1367 0.424658048443114 1987 13040088
SGTC_3295 9122362 53.5725 µM 0.189050586081262 0.416900059003463 no 1368 0.425026584804845 1918 4730473
SGTC_1293 1000-1278 195 µM 0.188839783672332 0.416990706511863 no 1369 0.425109194955951 2032 678847
SGTC_1346 1488-2224 62.4 µM 0.187789514498266 0.417442400250218 no 1370 0.425520827877664 2088 3722427
SGTC_2926 9010726 65.15 µM 0.186952452295449 0.417802477218496 no 1371 0.425848956568003 1906 2994293
SGTC_2740 felodipine 17.08 µM 0.185118013178248 0.418591833966688 no 1372 0.426568236655332 2095 3333 L-type calcium channel blocker
SGTC_3290 9121031 71.43 µM 0.183964028327743 0.419088560365995 no 1373 0.427020837245975 1951 17014854
SGTC_2513 baicalein 25.65 µM 0.183715186612939 0.419195689841192 no 1374 0.427118447248639 1914 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3353 9151644 39.2805 µM 0.183239388170752 0.419400543702479 no 1375 0.427305095124312 1981 4909158
SGTC_2533 agelasine 13.65 µM 0.182922851392136 0.419536839948014 no 1376 0.427429276295037 2099 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_585 0kpi-0023 191 µM 0.182254789055254 0.419824529780633 no 1377 0.427691388741865 2074 64601
SGTC_1061 3448-9325 110 µM 0.181936634036359 0.419961552972374 no 1378 0.42781622722707 2126 723482
SGTC_3132 9126706 49.47 µM 0.181809831036266 0.420016167268596 no 1379 0.427865984529311 2003 850858
SGTC_1112 tnp00069 1.16933 µM 0.180476375804904 0.420590582071171 no 1380 0.428389299621804 2077 145826
SGTC_320 4092-0846 5.34 µM 0.179887365363315 0.420844365039478 no 1381 0.428620497188186 2056 1359356
SGTC_3251 9135047 49.47 µM 0.179100489773827 0.421183452148817 no 1382 0.428929398720592 2079 17682963
SGTC_3277 9138724 49.47 µM 0.17843661324704 0.421469580943093 no 1383 0.429190048725505 2010 15943418
SGTC_86 0417-1630 471.922 µM 0.178372555729729 0.421497191737419 no 1384 0.429215200507696 2098 3634867
SGTC_573 3702-0553 84.7 µM 0.177901149969008 0.421700394234269 no 1385 0.429400303854327 1997 1222756
SGTC_2462 5162487 171.77 µM 0.177451954358371 0.421894042304144 no 1386 0.429576700553524 2109 2259986
SGTC_482 fipronil 114 µM 0.176789797161169 0.422179532467307 no 1387 0.429836751752961 2107 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.176682783615874 0.422225675375621 no 1388 0.429878782399267 2026 97141
SGTC_150 3970-0969 77.2 µM 0.174915648253446 0.422987796042267 no 1389 0.430572957151871 1994 6615640
SGTC_2904 7225135 42.03 µM 0.174547148357386 0.423146757124549 no 1390 0.43071774019391 2116 4446116
SGTC_3024 9090631 49.47 µM 0.174108653601426 0.423335928433763 no 1391 0.430890036241335 2136 25236383
SGTC_478 N-arachidonylglycine 10 µM 0.173994964970519 0.423384977807279 no 1392 0.430934709623808 2096 5283389
SGTC_94 0334-0113 514.748 µM 0.173882606512175 0.423433454462991 no 1393 0.43097886118984 1922 6795178
SGTC_2450 5739737 12.93 µM 0.173772662262763 0.423480890638802 no 1394 0.431022064920823 1993 2262825
SGTC_3247 9135149 49.47 µM 0.173761734309151 0.423485605637495 no 1395 0.431026359218432 2085 8934436 YOR116C RPO31
SGTC_2656 pseudo-anisatin 100 µM 0.173585697949833 0.423561560178248 no 1396 0.431095536378162 2019 6708809 A neurotoxin.
SGTC_1009 4106-0057 9.87 µM 0.173251564623596 0.423705736746451 no 1397 0.431226846851568 2134 2928005
SGTC_2587 piperic acid 92.2 µM 0.173075307017533 0.423781794984817 no 1398 0.431296117084419 1969 5370536
SGTC_1870 st057514 26.5 µM 0.172634240530844 0.423972135321686 no 1399 0.431469467956014 1988 5393161
SGTC_217 ketoconazole 989 nM 0.171759453721473 0.424349698224533 no 1400 0.431813321481612 2058 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2265 7929201 200 µM 0.171742393398596 0.424357062247134 no 1401 0.431820027918164 2085 1265108
SGTC_2225 6654152 15.4 µM 0.170516533197635 0.424886269039753 no 1402 0.432301966576373 2080 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2415 st077333 57.7 µM 0.169286640929279 0.425417352560615 no 1403 0.432785591661372 2173 2766255
SGTC_550 4123-0385 25.7 µM 0.167733392639852 0.426088258729382 no 1404 0.433396512410483 1993 5731123
SGTC_1884 5633444 25 µM 0.165499799748475 0.42705340587462 no 1405 0.434275303718401 2033 5724239
SGTC_2597 laccaic acid a 100 µM 0.165413179815229 0.427090843635845 no 1406 0.434309390289817 1998 5491415 A textile dye.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.164420430861677 0.427519963719843 no 1407 0.434700090471245 2105 5355888
SGTC_173 1273-0061 2.693 µM 0.164332365163783 0.427558034652245 no 1408 0.434734752151775 1946 2847414 YPL266W DIM1
SGTC_2302 7771753 200 µM 0.16373445073434 0.427816531770104 no 1409 0.434970097881183 1959 2203047
SGTC_2964 9083345 53.42 µM 0.163602881126718 0.427873417591682 no 1410 0.435021888229039 1979 17741579
SGTC_1704 st028805 70.8 µM 0.161714250416828 0.428690156157679 no 1411 0.435765441023173 2011 2876101
SGTC_294 k038-0071 157 µM 0.160743147260231 0.429110228968657 no 1412 0.436147852342692 2012 24152826
SGTC_2980 9014342 25.29 µM 0.159057159328009 0.42983973195185 no 1413 0.436811920175944 2017 2996599
SGTC_2353 9059630 146.67 µM 0.158826549638869 0.429939532165503 no 1414 0.436902765364408 2089 4779114
SGTC_2583 asiatic acid 100 µM 0.158815367885151 0.429944371370949 no 1415 0.436907170331267 2052 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1899 st063254 59.6 µM 0.158202335394637 0.430209693797394 no 1416 0.437148681775599 1956 3093813
SGTC_363 0455-0021 3.06 µM 0.157844633538171 0.430364522874213 no 1417 0.43728961350536 2048 4597466
SGTC_797 k781-0471 270 µM 0.157417701134994 0.43054933198633 no 1418 0.437457831943397 2070 23738129
SGTC_1504 k297-0033 30 µM 0.15741443946051 0.430550743947992 no 1419 0.437459117140721 1954 4388117
SGTC_1856 st057054 55.7 µM 0.157189047038512 0.43064831728699 no 1420 0.437547930095483 2135 1266018
SGTC_3275 9138069 49.47 µM 0.157128006006684 0.43067474293837 no 1421 0.43757198306247 2045 17617007
SGTC_2153 5569715 200 µM 0.156780639297014 0.430825129519628 no 1422 0.437708865871925 2107 2054701
SGTC_1777 st045864 34.765 µM 0.155960713482382 0.431180142372398 no 1423 0.438031994156893 2131 4691462
SGTC_1038 k292-0204 154 µM 0.155932781163649 0.431192237535637 no 1424 0.438043002860189 2052 4454212
SGTC_2914 7968218 45.32 µM 0.155698203426443 0.43129381618178 no 1425 0.438135456679174 2092 2977111
SGTC_1579 chlormadinone acetate 49.4 µM 0.153763928298111 0.432131583413956 no 1426 0.438897938287424 2132 45114258 A steroidal progestin.
SGTC_235 0330-0087 5 mM 0.152500878106066 0.432678796778081 no 1427 0.439395948954848 2020 46494818 YHR062C RPP1
SGTC_903 1134-0042 114 µM 0.151667064873945 0.433040115125223 no 1428 0.439724767513863 2002 701009
SGTC_2938 9059746 27.26 µM 0.151148340285406 0.433264923599298 no 1429 0.439929350234183 2076 6471769
SGTC_880 0833-0487 87.2 µM 0.149937487389476 0.433789775378333 no 1430 0.440406967678131 2046 76075
SGTC_712 r015-0009 80.6 µM 0.149866440574213 0.433820574701334 no 1431 0.440434994590283 2095 6813872 YLR060W FRS1
SGTC_1368 1852-0141 284 µM 0.149602661603009 0.433934928361751 no 1432 0.44053905408168 2031 2838987
SGTC_1710 st031758 61.5 µM 0.14952401024287 0.433969026429868 no 1433 0.440570082446916 2135 5394341
SGTC_2352 9027995 87.8 µM 0.148954495108565 0.434215945461513 no 1434 0.440794769966161 2065 2997347
SGTC_1509 1326-1131 80 µM 0.148384113590718 0.434463265849266 no 1435 0.441019818399651 2138 768313
SGTC_737 1950-0117 57.9 µM 0.147882108692328 0.434680959006034 no 1436 0.441217904071776 2164 5393513
SGTC_2634 4'-methoxyflavone 100 µM 0.147686361327829 0.434765849726973 no 1437 0.441295147840314 2008 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1694 st024011 44.9 µM 0.147634728672455 0.434788242015634 no 1438 0.441315522948662 2134 2787533
SGTC_2254 7938975 95.19 µM 0.145998243320986 0.435498068552772 no 1439 0.441961387597625 2128 2969277
SGTC_999 SEC7.066 22.7 µM 0.145772886987529 0.435595833337422 no 1440 0.4420503401421 2051 740511 YDR170C SEC7
SGTC_2929 9013348 24.6 µM 0.14531715412527 0.435793552806354 no 1441 0.442230235725669 2058 2995952
SGTC_2756 carbadox 75.1 µM 0.145079946130328 0.435896471727377 no 1442 0.442323875714849 2021 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_976 1348-1067 47.6 µM 0.144280161117536 0.436243511422858 no 1443 0.442639621761069 2107 5310671 YGL099W LSG1
SGTC_2210 7115885 190.385 µM 0.143924669248722 0.436397780887684 no 1444 0.44277997762533 2092 2927039
SGTC_1552 6-methylflavone 10.6 µM 0.143855689348051 0.436427716568343 no 1445 0.442807213211746 2159 689013
SGTC_2890 9046729 58.44 µM 0.142815599993986 0.436879135320352 no 1446 0.443217908182337 2012 903329
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.142735780107314 0.436913782087668 no 1447 0.443249428794857 2062 390807
SGTC_1329 1447-1697 50.6 µM 0.142303948060087 0.437101232286743 no 1448 0.443419964081729 2059 2840515
SGTC_284 0988-0104 32.6 µM 0.140678706969256 0.437806845232035 no 1449 0.444061883583004 2138 4666532
SGTC_3258 9138477 49.47 µM 0.139943798231746 0.438125977510627 no 1450 0.444352197887817 2162 4970355
SGTC_1930 st074634 34.3 µM 0.139553553921188 0.43829545649694 no 1451 0.444506370000729 2123 684253 YOR116C RPO31
SGTC_499 genistein 192 µM 0.137734492663967 0.439085604440672 no 1452 0.445225128993161 2185 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2837 9008476 45.46 µM 0.137092700881905 0.439364438453708 no 1453 0.445478760924218 2083 2992805
SGTC_444 curcumin 90.4 µM 0.136416126646174 0.43965841668894 no 1454 0.445746162816124 2120 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_428 3448-4153 16.5 µM 0.135829942892256 0.439913146271985 no 1455 0.44597785971013 1932 3834874
SGTC_2496 diffractaic acid 79.83 µM 0.135760140631878 0.439943480912495 no 1456 0.446005451208985 2151 94870 An apoptosis inducer which activates caspases.
SGTC_2486 5283202 22.39 µM 0.135535730747234 0.440041007265045 no 1457 0.446094157916386 2015 1377751
SGTC_1269 0831-0796 3.05 µM 0.135534297891727 0.440041629981803 no 1458 0.446094724316751 2148 927758
SGTC_1755 st041960 45.185 µM 0.135509124455365 0.44005257034199 no 1459 0.446104675263781 2068 2257073
SGTC_1650 st011916 45.8 µM 0.134619227100524 0.440439348541572 no 1460 0.446456469480499 2165 242528
SGTC_401 neomycin 50 µM 0.133785960026528 0.440801564920914 no 1461 0.446785914828957 2074 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2332 7982454 138.89 µM 0.133474883917981 0.440936800620583 no 1462 0.446908913127495 2166 2981748
SGTC_2348 9022543 33.42 µM 0.132049680999016 0.441556474170307 no 1463 0.447472498008365 2091 3162678 YDL140C RPO21
SGTC_2954 9074818 52.69 µM 0.131384183151136 0.441845879547033 no 1464 0.44773570010821 2101 16648742
SGTC_927 2425-1185 123 µM 0.129757085425054 0.442553586774289 no 1465 0.44837930832613 2063 730375
SGTC_2117 5521686 200 µM 0.129515303196819 0.442658765815441 no 1466 0.448474958367716 2076 803312
SGTC_920 mycophenolic acid 780.421 nM 0.1287613587146 0.442986769344183 no 1467 0.448773241106194 2061 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2710 st078562 53.7235 µM 0.128517747157861 0.443092760909742 no 1468 0.448869627242136 2158 17250908
SGTC_2326 6164455 177.58 µM 0.127932902976934 0.443347234044572 no 1469 0.449101036087659 2077 2888790
SGTC_2947 9072639 7.68 µM 0.12730238429644 0.443621606907016 no 1470 0.44935053663328 2079 16488146
SGTC_1003 4049-0218 100 µM 0.127258122022855 0.443640868838843 no 1471 0.449368052270501 2133 295161
SGTC_1190 1486-1332 13 µM 0.127188598525907 0.443671124147677 no 1472 0.449395564575413 2162 4150046
SGTC_794 k038-0031 316 µM 0.126985223104617 0.443759631162785 no 1473 0.449476047058607 2177 6624242
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.126621255206228 0.443918033469642 no 1474 0.449620086563739 2114 364106
SGTC_29 0299-0004 12.984 µM 0.126542022190839 0.443952517623392 no 1475 0.449651443737965 2161 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2765 myclobutanil 7.74 µM 0.125794627213531 0.444277823113983 no 1476 0.449947247425829 2080 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_151 3013-0144 2.285 µM 0.125253938021292 0.444513182822627 no 1477 0.450161258527313 2185 906558 YHR107C CDC12
SGTC_1216 1165-0504 9.65 µM 0.125167468248772 0.444550824564198 no 1478 0.450195485619806 2194 6304004
SGTC_937 3122-0005 46.7 µM 0.124875669922591 0.444677852956617 no 1479 0.450310990082449 2185 759535
SGTC_2131 toluylene red 5.2905 µM 0.124810957201904 0.444706025077202 no 1480 0.450336606317513 2063 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_3118 9124250 49.47 µM 0.123884334303754 0.445109452869528 no 1481 0.450703428402243 2083 1504786
SGTC_3327 9140648 26.9345 µM 0.123367561436956 0.445334467215637 no 1482 0.45090802152035 2167 8029710
SGTC_2734 clemastine 41.6 µM 0.122372002209053 0.445768005328019 no 1483 0.451302205420419 2201 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_822 1487-0950 154 µM 0.121912427398456 0.445968159174449 no 1484 0.451484186702312 2209 1958375
SGTC_1358 1509-0022 2.48 µM 0.120953249842687 0.446385944119419 no 1485 0.45186403223092 2100 3258434
SGTC_1328 1441-0025 69.2 µM 0.120800509505333 0.446452478093325 no 1486 0.451924523267234 2172 4562601
SGTC_906 1165-0455 526 µM 0.12075567604196 0.446472007919299 no 1487 0.451942279251552 2180 3252859
SGTC_470 aa-861 153 µM 0.120651597436085 0.446517345917881 no 1488 0.451983499236972 2053 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_168 3970-0862 530.542 µM 0.120463319188081 0.446599364154992 no 1489 0.452058067525209 2114 3135186
SGTC_23 0213-0011 39.996 µM 0.119273323910469 0.447117805553221 no 1490 0.452529408523098 2195 627608
SGTC_2691 st077356 60.2 µM 0.119073128475282 0.447205032957123 no 1491 0.452608709813553 2163 2839272
SGTC_1819 st053448 58.6 µM 0.11860184320757 0.447410387326705 no 1492 0.452795402496496 2117 2857616
SGTC_131 0141-0277 33.849 µM 0.11827391233977 0.44755328582785 no 1493 0.452925313615181 2174 1547771
SGTC_35 0133-0054 64.071 µM 0.116848337267789 0.448174570465263 no 1494 0.453490119239857 2101 99677
SGTC_43 0570-0105 72.5 µM 0.116442087685636 0.448351642798815 no 1495 0.453651090543735 2146 1114046 YDL195W SEC31
SGTC_438 sphingosine 6.67 µM 0.114730162609251 0.449097933604653 no 1496 0.454329502739865 2023 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2157 5649910 96.377 µM 0.114086775276033 0.449378456403816 no 1497 0.454584502786551 2096 2858091
SGTC_1828 st055811 49 µM 0.113883467286825 0.449467105826157 no 1498 0.454665085743802 2210 5877589
SGTC_3034 9090421 49.47 µM 0.112659414477679 0.450000888984811 no 1499 0.455150289443614 2199 17173761
SGTC_2388 9080168 200 µM 0.112311874959311 0.450152460041584 no 1500 0.455288063260461 2119 15943073
SGTC_859 0439-0102 54.6 µM 0.112184786258191 0.450207888558746 no 1501 0.45533844591193 2229 610143
SGTC_1673 st016611 27.3 µM 0.112140170488171 0.450227347529003 no 1502 0.455356133420154 2162 5226799
SGTC_2054 5233173 129 µM 0.111415177613232 0.450543566693859 no 1503 0.455643562499163 2135 6889
SGTC_901 1112-0062 60.1 µM 0.109473823525321 0.451390478544741 no 1504 0.456413341383078 2206 1908457
SGTC_1878 temozolomide 1 mM 0.109363122222194 0.451438778473514 no 1505 0.456457241231906 2229 5394 DNA alkylating agent.
SGTC_2134 5324836 1.464 µM 0.107724267062046 0.452153908769209 no 1506 0.457107209597476 2154 699272
SGTC_2739 tacrine 100.86 µM 0.107171642624369 0.452395086905646 no 1507 0.457326405871599 2142 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_355 1311-2252 105 µM 0.106658224746862 0.45261917013185 no 1508 0.457530062655281 2086 5338538
SGTC_1145 3546-0597 10.2 µM 0.104057770187478 0.453754378948562 no 1509 0.458561751685787 2128 875334
SGTC_1214 0358-0031 63.7 µM 0.103693872205481 0.453913266223536 no 1510 0.458706144855955 2217 4301366
SGTC_1602 st001878 87.6 µM 0.101434427785105 0.454899962224921 no 1511 0.459602803990935 2178 595405 YLR310C CDC25
SGTC_2766 oltipraz 83.91 µM 0.101233014659892 0.454987932636124 no 1512 0.459682744710266 2212 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.101179087834247 0.455011486416517 no 1513 0.459704148503949 2156 641818 YHR062C RPP1
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.100693835667028 0.455223438557096 no 1514 0.459896752464095 2249 4000243
SGTC_2675 theaflavin digallate 100 µM 0.100528671914284 0.455295582950635 no 1515 0.459962310616787 2202 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2838 9002687 71.43 µM 0.0991370325442102 0.455903516640933 no 1516 0.460514734591624 2094 6457060
SGTC_773 4358-1457 44.6 µM 0.0987527893833552 0.456071390421105 no 1517 0.460667276901073 2242 1186886
SGTC_1663 st014140 55.4 µM 0.0980552997135946 0.456376139941538 no 1518 0.460944191034896 2254 4207120
SGTC_1669 st015249 58.4 µM 0.0979936825794509 0.456403063142242 no 1519 0.460968654897912 2256 722793
SGTC_3083 9117465 49.47 µM 0.0965658221365832 0.457027013158834 no 1520 0.461535599795477 2080 16420915
SGTC_2145 5634607 200 µM 0.096117243121521 0.45722305627959 no 1521 0.461713728340961 2154 308662
SGTC_693 4161-2696 114 µM 0.0961157943895659 0.457223689437853 no 1522 0.461714303637837 2190 805759
SGTC_2355 9061122 103.12 µM 0.0953452244664862 0.457560477031815 no 1523 0.462020311158191 2221 5302957
SGTC_963 1269-2853 151 µM 0.093443408440694 0.458391820364038 no 1524 0.462775653202637 2159 3668223
SGTC_1202 1988-0068 29.6 µM 0.0933633671143888 0.458426812951245 no 1525 0.462807446085335 2105 2850480
SGTC_1745 st081495 74 µM 0.0932137514300003 0.458492223024547 no 1526 0.46286687494673 2184 13842402 YBL026W LSM2
SGTC_2121 5257820 149.641 µM 0.0922787271826465 0.458901029118261 no 1527 0.46323829474706 2256 791256
SGTC_1066 ketoconazole 628 nM 0.0902258461712158 0.459798730206006 no 1528 0.464053872906401 2217 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2330 7979373 200 µM 0.0890132292431181 0.460329090139077 no 1529 0.464535698220248 2141 1863007
SGTC_266 formosanin C 406 nM 0.0882623062009313 0.460657555355158 no 1530 0.464834098644259 2245 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1749 st037932 54.2 µM 0.0873079465077659 0.461075045583481 no 1531 0.4652133688717 2148 594497
SGTC_3181 9108277 49.47 µM 0.0864608460415068 0.46144565059324 no 1532 0.465550039904508 2214 17097298
SGTC_3175 9106517 49.47 µM 0.08424469456235 0.462415370655159 no 1533 0.466430941671934 2163 41468073
SGTC_2182 6325192 200 µM 0.0834300092168094 0.46277190849995 no 1534 0.466754813889622 2261 736248
SGTC_1732 st034308 51.822 µM 0.0823222468040788 0.463256756146339 no 1535 0.467195232034582 2094 830119
SGTC_526 4469-0568 170 µM 0.0817543580685441 0.463505332022015 no 1536 0.467421025751014 2243 2901964
SGTC_2907 7721985 69.9 µM 0.0815923575967691 0.463576245376015 no 1537 0.467485439393109 2191 3267881
SGTC_1514 1189-1591 158 µM 0.0814994906171911 0.463616897069753 no 1538 0.467522364980638 2250 767698 YMR146C TIF34
SGTC_1715 st032160 10.2275 µM 0.0807765721431524 0.463933361153481 no 1539 0.467809819947288 2228 5289825
SGTC_2168 5727979 200 µM 0.0805081470087384 0.464050872498271 no 1540 0.46791655844695 2247 695210
SGTC_1325 1431-0015 227 µM 0.0798893192456185 0.464321795285414 no 1541 0.468162642342423 2138 1103340
SGTC_3328 9140624 29.0385 µM 0.0793479635825172 0.464558814358702 no 1542 0.468377928556567 2244 4904392
SGTC_2825 7998094 58.44 µM 0.0789318920967303 0.464740989432132 no 1543 0.468543398072133 2208 2987815
SGTC_2003 4023581 200 µM 0.0771059260364159 0.46554056754207 no 1544 0.469269639371379 2190 16641307
SGTC_2202 7226349 200 µM 0.0768908508703725 0.465634756715252 no 1545 0.469355187973945 2257 844334
SGTC_3146 9095609 49.47 µM 0.0755963173981096 0.466201720098211 no 1546 0.469870133186421 2216 17173999
SGTC_504 lovastatin 124 µM 0.0755051041786994 0.466241671109834 no 1547 0.469906418292193 2115 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2186 6124449 200 µM 0.0738980946876055 0.466945590025967 no 1548 0.470545735962277 2240 3834182 YLR033W RSC58
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.0731299496228099 0.467282097529758 no 1549 0.470851354552822 2301 229346 A bile salt which induces apoptosis.
SGTC_170 4197-0004 226 µM 0.0728958574447951 0.46738465283841 no 1550 0.470944495227704 2219 218692
SGTC_3092 9117248 49.47 µM 0.0728044477723962 0.467424699818734 no 1551 0.470980865770817 2298 17141857
SGTC_1611 st001856 99.4 µM 0.0721365140767313 0.467717334495644 no 1552 0.471246633937152 2167 647478
SGTC_3018 9082602 49.47 µM 0.071414210085489 0.468033809481692 no 1553 0.471534050236357 2194 17332089
SGTC_1051 3253-3903 78 µM 0.0712233673099451 0.468117429963702 no 1554 0.471609992108304 2281 5509239
SGTC_2488 5268135 45.7 µM 0.0710047243954504 0.468213233201649 no 1555 0.471696997729907 2235 1270356 YLR208W SEC13
SGTC_1152 3909-8331 15.9 µM 0.069537984897056 0.468855964940724 no 1556 0.472280699120136 2225 16001939
SGTC_950 1165-0508 94.1 µM 0.0691680547884523 0.469018082836006 no 1557 0.472427925386827 2211 6148369
SGTC_808 0711-0032 135 µM 0.0691185159981495 0.469039793069182 no 1558 0.472447641319518 2280 4252555
SGTC_1053 3366-3204 134 µM 0.0686807979807537 0.469231625731502 no 1559 0.472621851548879 2206 3632071 YPR165W RHO1
SGTC_2910 7948405 25.97 µM 0.0679297030713239 0.469560814398714 no 1560 0.472920796863063 2267 2971328
SGTC_2038 4100038 30.985 µM 0.067880858027011 0.469582222849058 no 1561 0.472940238341151 2227 3596803
SGTC_2700 st077718 96.8 µM 0.0671258624601577 0.469913143411879 no 1562 0.473240752529554 2212 904970
SGTC_191 3914-0123 66.505 µM 0.0671073932216178 0.469921238887385 no 1563 0.473248104112909 2216 3144412
SGTC_254 nsc-64875 3.808 µM 0.0669987228453641 0.469968871767087 no 1564 0.473291359969617 2267 56993
SGTC_1758 st042942 75.2445 µM 0.0665419332087172 0.470169098511743 no 1565 0.473473186897878 2280 669317
SGTC_642 0335-0876 158 µM 0.0651830995427355 0.47076476684392 no 1566 0.474014108560288 2241 6812350
SGTC_2581 avocatin a 64 µM 0.0626340342007444 0.471882369318699 no 1567 0.475028963620149 2243 6710728 A skin care supplement.
SGTC_3241 9133421 49.47 µM 0.0625312435046036 0.471927441182724 no 1568 0.475069890948611 2286 17018221
SGTC_394 menadione 8.33 µM 0.0622104899657133 0.472068088125864 no 1569 0.475197604443841 2314 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2955 9076254 12.21 µM 0.0613280176226674 0.472455060585375 no 1570 0.475548988978137 2293 16459619
SGTC_1411 3909-8223 150 µM 0.0609870767693391 0.472604573353789 no 1571 0.47568475057059 2320 X1411
SGTC_1781 st038725 66.3 µM 0.060928708237874 0.47263017008935 no 1572 0.47570799302259 2223 4270275 YIL048W NEO1
SGTC_2802 7925815 54.55 µM 0.060845975821199 0.472666451473173 no 1573 0.475740937358172 2258 1262923
SGTC_3156 9099931 49.47 µM 0.0607630090127612 0.47270283587465 no 1574 0.475773975195913 2240 18111053
SGTC_2473 5854593 8.94 µM 0.0593996684518039 0.473300749899778 no 1575 0.476316888566009 2257 2872951
SGTC_2349 9023730 187.07 µM 0.0582589938288667 0.473801056623644 no 1576 0.476771165095554 2277 4126287
SGTC_1086 cerivastatin 2.18 µM 0.0578405461454835 0.473984600687037 no 1577 0.476937820534957 2323 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_332 4112-0506 40.9 µM 0.0568019851709626 0.474440169350661 no 1578 0.477351466277793 2290 2790355
SGTC_1007 4101-0031 70 µM 0.0567770818146412 0.474451093713963 no 1579 0.477361385272018 2304 1146276
SGTC_1688 st021091 57.6 µM 0.0563374161205831 0.474643965160905 no 1580 0.477536506199499 2315 3656366
SGTC_813 k007-0158 173 µM 0.0557549927946409 0.474899470311481 no 1581 0.47776849484106 2278 6523916
SGTC_386 1509-0011 3.07 µM 0.0556264695482029 0.474955853979349 no 1582 0.477819688748592 2300 3107280
SGTC_1243 0416-0003 5.65 µM 0.0536288654860557 0.475832274739181 no 1583 0.478615429133054 2250 2141977
SGTC_1398 3558-0053 112 µM 0.0522153686673801 0.476452497537524 no 1584 0.479178543606453 2261 4532369
SGTC_220 paclitaxel 373.376 µM 0.0517241373927192 0.476668056442509 no 1585 0.479374252060772 2299 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2869 9037858 32.47 µM 0.0514710440858663 0.476779119866226 no 1586 0.479475087364627 2327 27187042
SGTC_835 0312-0010 67.2 µM 0.0510717541195268 0.476954341560855 no 1587 0.479634171778725 2313 1626196
SGTC_2414 st077232 92.9 µM 0.0503214789460208 0.477283599243471 no 1588 0.479933103863743 2178 729801
SGTC_1672 st016598 6.51 µM 0.0480741527115197 0.478269928533687 no 1589 0.480828572764613 2191 4665860 YNL267W PIK1
SGTC_1064 honokiol 6.76 µM 0.0480088657161683 0.478298584369983 no 1590 0.480854588468138 2243 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2403 6032726 181.2 µM 0.0464818650600769 0.478968848779193 no 1591 0.481463094023788 2280 2881040
SGTC_1394 3474-0001 65.7 µM 0.0458226807107257 0.479258210832426 no 1592 0.48172579060144 2270 5017666 YIL048W NEO1
SGTC_653 0203-0016 55.2 µM 0.0456470277253282 0.479335319047587 no 1593 0.481795792754664 2284 295302
SGTC_1905 st060207 84.5 µM 0.0447331990866079 0.479736484307874 no 1594 0.482159985565605 2243 1948547
SGTC_3086 9117350 49.47 µM 0.0436216797991478 0.480224462198472 no 1595 0.482602985081933 2341 2679265
SGTC_750 4073-0104 132 µM 0.0435015930629914 0.480277184323154 no 1596 0.482650847324639 2325 22330957
SGTC_1134 3477-0009 42.5 µM 0.0410787534266082 0.481340965030439 no 1597 0.483616556306665 2340 3973534
SGTC_1232 0279-0259 161 µM 0.0410511690870715 0.481353077089419 no 1598 0.483627551591229 2310 1560000
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0406837005734838 0.481514431160529 no 1599 0.483774027947565 2291 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_395 anisomycin 6.25 µM 0.0400295208039549 0.481801686565614 no 1600 0.48403479547518 2239 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1040 k898-0338 155 µM 0.0380489569750318 0.482671424479629 no 1601 0.484824324121959 2341 20969351
SGTC_1999 st074831 12.5 µM 0.0377426324564276 0.482805950231972 no 1602 0.484946442205632 2244 17112523
SGTC_405 ebelactone b 50 µM 0.0373817972483829 0.482964417457844 no 1603 0.485090293108738 2266 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2375 9072683 200 µM 0.0365655269189686 0.483322907042279 no 1604 0.48541571533581 2357 16798029
SGTC_519 k048-0011 62.8 µM 0.0357960448177769 0.483660860524376 no 1605 0.485722493412889 2255 6836379
SGTC_3339 9145883 14.936 µM 0.035795527506222 0.483661087729532 no 1606 0.485722699658163 2331 2030670
SGTC_825 1988-2224 89.6 µM 0.0346575389019013 0.484160909261986 no 1607 0.486176409808803 2328 1180859
SGTC_2308 7584454 197.62 µM 0.0345120670583967 0.484224804471463 no 1608 0.486234409980108 2331 893577
SGTC_941 3237-0776 460 µM 0.0344857140627623 0.484236379470771 no 1609 0.486244917049802 2327 760008
SGTC_3075 9116269 49.47 µM 0.0336566340588563 0.484600542165071 no 1610 0.486575480185776 2307 17015205 YNL244C SUI1
SGTC_1321 1326-2144 215 µM 0.0335639638531546 0.4846412471609 no 1611 0.48661242937319 2337 3513030
SGTC_2679 rapamycin 1 nM 0.0333898773586252 0.484717714349589 no 1612 0.486681840930406 2328 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1179 1021-1431 9.29 µM 0.0318965227001435 0.48537369057243 no 1613 0.487277285856822 2306 2840958
SGTC_798 1287-0182 476 µM 0.031287377390174 0.485641277351566 no 1614 0.487520178432249 2347 1649755
SGTC_635 k038-0028 24.7 µM 0.0303017547590861 0.486074257612494 no 1615 0.487913198560688 2317 4035102
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.0301148754010476 0.486156354868446 no 1616 0.48798771862872 2356 756377
SGTC_2037 5169046 200 µM 0.0289086327996884 0.486686278655556 no 1617 0.488468730261051 2325 5718022
SGTC_2174 5790901 200 µM 0.0288785082093896 0.48669951322761 no 1618 0.488480743218315 2323 786020
SGTC_378 3970-0959 8.33 µM 0.0286924119583056 0.486781270821184 no 1619 0.488554954128939 2330 6615653
SGTC_446 go6976 132 µM 0.0276895405055761 0.487221871424165 no 1620 0.48895488298695 2339 3501 A protein kinase C inhibitor.
SGTC_2592 piperlongumine 83.33 µM 0.027682041064514 0.487225166280988 no 1621 0.48895787368466 2335 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_154 3389-1638 511.116 µM 0.0276291073533624 0.487248422572196 no 1622 0.488978983105983 2208 5238686
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0261722638212234 0.487888499813909 no 1623 0.489559969283069 2256 688788
SGTC_2733 amorolfine 100 µM 0.0261647482685787 0.487891801921518 no 1624 0.489562966528361 2360 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1826 st055655 41.6 µM 0.0253071676598573 0.488268602422417 no 1625 0.489904978398808 2268 676168
SGTC_335 4077-0256 27.6 µM 0.0247552415316861 0.488511111181555 no 1626 0.490125096094793 2356 3121989
SGTC_1135 dihydrocapsaicin 536.708 nM 0.0238069235050528 0.488927798965088 no 1627 0.490503308728687 2355 107982 A Capsaicinoid.
SGTC_2456 5770359 74.46 µM 0.0234745596940502 0.489073841400495 no 1628 0.490635865657568 2365 3118787
SGTC_4 0960-0234 25.671 µM 0.0232562706800532 0.489169759558498 no 1629 0.490722926606041 2281 6821112
SGTC_1829 berberine 14.4 µM 0.0231203073770661 0.489229503374834 no 1630 0.490777153535362 2366 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_442 cape 100 µM 0.0223879929238334 0.489551294768126 no 1631 0.491069229105733 2361 5281787
SGTC_2833 9001315 45.46 µM 0.0209108311868053 0.490200405173279 no 1632 0.491658393238149 2315 2989378
SGTC_1280 0880-0253 10.1 µM 0.0201155114262152 0.490549904052821 no 1633 0.49197561316019 2351 6836607
SGTC_2824 7998404 51.95 µM 0.0200957337982568 0.490558595315848 no 1634 0.491983501697612 2350 837851
SGTC_3267 9137951 49.47 µM 0.0196732326652517 0.490744264169994 no 1635 0.492152021942704 2363 16643986
SGTC_2977 9011197 71.43 µM 0.0195198595017009 0.490811664770439 no 1636 0.492213197234726 2359 2704722
SGTC_233 rapamycin 362 pM 0.0182210852084714 0.491382427926429 no 1637 0.492731240932064 2376 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1969 st069479 40.1 µM 0.0175703160535394 0.491668423554637 no 1638 0.492990818689159 2376 3895485
SGTC_1423 4048-0112 5.59 µM 0.0173522394610856 0.491764263346444 no 1639 0.493077805400112 2375 X1423
SGTC_2339 9000433 200 µM 0.0169830052241516 0.491926534628074 no 1640 0.493225086842233 2359 2988954
SGTC_25 0118-0223 35.662 µM 0.0155447671908185 0.492558624824065 no 1641 0.493798784872975 2373 5333628
SGTC_544 k015-0020 52.4 µM 0.0150785138148583 0.492763542271371 no 1642 0.49398477125315 2355 3008304
SGTC_1213 1315-0166 115 µM 0.0147623504006393 0.49290249656371 no 1643 0.494110888167263 2341 768401
SGTC_1254 0550-0035 264 µM 0.013339197870821 0.49352798464415 no 1644 0.494678587793361 2375 15121435
SGTC_1396 3511-0007 98.6 µM 0.0129024008033151 0.493719964067955 no 1645 0.494852829611181 2374 X1396
SGTC_792 4534-1957 155 µM 0.0125421272668658 0.493878311250361 no 1646 0.494996546325426 2322 1717904
SGTC_3015 9080845 49.47 µM 0.0114631609378703 0.494352543476469 no 1647 0.495426960587713 2378 5296973
SGTC_422 cantharidin 155 µM 0.0109648481512511 0.494571566931218 no 1648 0.495625746125683 2390 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_591 4299-0174 154 µM 0.0105494478709437 0.494754149099583 no 1649 0.495791457271584 2373 5509088
SGTC_1310 1188-0297 994 nM 0.0103738152188907 0.494831345794414 no 1650 0.495861520728039 2377 1588352
SGTC_2300 7976697 71.57 µM 0.0100347878971017 0.494980360707602 no 1651 0.495996766018686 2378 2236109
SGTC_1907 st060210 83.7 µM 0.00931150904398382 0.495298270543683 no 1652 0.496285299028122 2383 688793
SGTC_2591 skatole 100 µM 0.0089882218881244 0.495440369090316 no 1653 0.496414266544048 2377 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1919 st067113 52.3 µM 0.00857507596704585 0.495621965251251 no 1654 0.496579081563597 2375 1268243
SGTC_2460 5552655 174.22 µM 0.00764876236876576 0.496029124861365 no 1655 0.496948615051202 2343 5401989
SGTC_1506 4226-2149 212 µM 0.00719292329661289 0.496229489716612 no 1656 0.497130463521401 2354 991114
SGTC_3240 9133527 49.47 µM 0.00677317907973704 0.496413989857924 no 1657 0.497297913152514 2391 17617455
SGTC_809 3998-0021 90 µM 0.00663932951310169 0.496472824099014 no 1658 0.497351310203069 2394 715485
SGTC_1693 xanthone 101.9 µM 0.00635586007713186 0.496597424747694 no 1659 0.497464395758711 2386 7020 An insecticide.
SGTC_27 0485-0001 32.618 µM 0.0060823728866844 0.496717637956706 no 1660 0.497573499251848 2396 2054479
SGTC_1848 st056003 16.4 µM 0.00600364000875851 0.496752245600074 no 1661 0.497604908552196 2396 146492
SGTC_1860 st056228 74.6 µM 0.00590882359119165 0.49679392291968 no 1662 0.497642734159055 2366 688679
SGTC_1761 st044296 37 µM 0.0051148192042667 0.497142935269193 no 1663 0.497959491259899 2393 1826700
SGTC_3184 9108758 49.47 µM 0.00493328717156795 0.497222729756236 no 1664 0.498031911148905 2389 902885
SGTC_2873 9040596 71.43 µM 0.00407894850002598 0.497598265557101 no 1665 0.498372739496106 2368 6463863
SGTC_3324 9138759 60.749 µM 0.00325859342556999 0.497958865427946 no 1666 0.498700011608542 2390 45595710
SGTC_345 1362-0200 395 µM 0.00321717859008658 0.497977070011664 no 1667 0.498716533650843 2396 1419823
SGTC_298 1391-0729 10 µM 0.00301964118881361 0.498063900938078 no 1668 0.49879533928887 2399 3237558
SGTC_3087 9117406 49.47 µM 0.00255713120618132 0.498267205423509 no 1669 0.498979853357097 2378 42546093
SGTC_2783 7738165 71.43 µM 0.00178546145308069 0.498606407557909 no 1670 0.49928770431479 2396 17201110
SGTC_1612 st002233 45.4 µM 0.00138090648141377 0.498784237817474 no 1671 0.49944909819437 2401 1035021
SGTC_612 0302-0167 22.4 µM 0.000155889524525528 0.499322719941644 no 1672 0.499937809077847 2401 235821
SGTC_1845 st056753 3.01 µM 0 0.499391244589671 no 1673 0.5 2400 5375839
SGTC_1887 st057648 70.8 µM -5.96375575584084e-05 0.499417459586547 no 1674 0.499976208056804 2406 688672
SGTC_3304 9125678 46.087 µM -0.000107379056083473 0.499438445411493 no 1675 0.499957161954581 2406 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2879 9041815 71.43 µM -0.000743138273709908 0.499717907473806 no 1676 0.49970353074972 2407 4942971
SGTC_2575 plumbagin 510 nM -0.000853888313927405 0.499766590127926 no 1677 0.49965934789023 2408 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1545 lovastatin 49.4 µM -0.00127282591858645 0.499950743535672 no 1678 0.499492216062594 2408 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1104 tacrolimus 29.8 µM -0.0014969367184514 0.499950743535672 no 1679 0.499402808874957 2410 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2738 aclarubicin 5.55 µM -0.00213080618712453 0.499672112029756 no 1680 0.499149931963881 2411 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_276 colchicine 750 µM -0.00232309164404374 0.499587588680726 no 1681 0.499073221355543 2419 2833 A microtubule depolymerizer.
SGTC_1230 0170-0365 3.77 µM -0.00245344643528001 0.499530288343436 no 1682 0.499021217466214 2412 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1024 4507-0395 26 µM -0.00291922471558875 0.499325545265636 no 1683 0.498835399489055 2435 4201836
SGTC_1987 st072290 61.9 µM -0.00293652209803069 0.499317941824191 no 1684 0.498828498861437 2426 54697379
SGTC_522 1273-0010 11.6 µM -0.0034565682855769 0.499089344316345 no 1685 0.498621031511744 2443 5705015
SGTC_1738 st035555 74 µM -0.00389590898480366 0.498896222874933 no 1686 0.498445761117101 2420 5331140
SGTC_212 3807-4682 38.772 µM -0.00512591465366114 0.498355549542678 no 1687 0.497955064874041 2419 3125501 YBL034C STU1
SGTC_2124 5246320 200 µM -0.00562528901008064 0.498136040468181 no 1688 0.497755846210028 2424 579342
SGTC_533 1222-0222 6.71 µM -0.00618296348940977 0.4978909051851 no 1689 0.497533370162054 2440 3982874
SGTC_1102 cgs 12066b 26.1 µM -0.0064779692023565 0.497761230732863 no 1690 0.497415682268809 2438 6438352 A 5-HT1B full agonist.
SGTC_1659 st012954 42.1 µM -0.00694991445995359 0.497553780187719 no 1691 0.497227407596744 2427 24207262
SGTC_1029 k015-0030 64.7 µM -0.00734465475993802 0.49738026673365 no 1692 0.497069933024566 2458 2208316
SGTC_802 4112-3352 742 µM -0.00740870913649253 0.497352110809316 no 1693 0.497044379720774 2455 704594
SGTC_1646 st011709 75.6 µM -0.0075230128532181 0.49730186717465 no 1694 0.49699878040624 2418 5757843
SGTC_2371 9071574 200 µM -0.0076750162581413 0.497235052234856 no 1695 0.49693814157213 2425 45596039
SGTC_966 1300-0360 30.2 µM -0.00768045932675984 0.49723265966947 no 1696 0.496935970165924 2421 70588
SGTC_389 tpck 16.7 µM -0.00791002888805386 0.497131749736992 no 1697 0.496844387944408 2421 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1898 st060199 18.6 µM -0.0106326182411834 0.495935020150838 no 1698 0.495758278955286 2418 688866
SGTC_668 1682-0499 62.6 µM -0.0111183897508543 0.495721500065246 no 1699 0.495564495623724 2436 682214
SGTC_210 3551-0445 56.827 µM -0.0111448821250755 0.495709855419468 no 1700 0.495553927350334 2417 2865180 YOR207C RET1
SGTC_3128 9127691 49.47 µM -0.0111827900247059 0.495693193119169 no 1701 0.495538805228785 2453 41316314
SGTC_1175 0741-0056 27.6 µM -0.0111878487314333 0.495690969580805 no 1702 0.495536787223029 2426 765927
SGTC_1931 st074438 57.1 µM -0.012645874222824 0.495050104994403 no 1703 0.494955160560454 2425 2787313
SGTC_2814 7977482 42.97 µM -0.0128068142130937 0.494979365735526 no 1704 0.494890959992965 2430 6456762
SGTC_1436 4092-1007 8.32 µM -0.0128441167038407 0.494962969891763 no 1705 0.494876079676143 2427 2881121
SGTC_659 k018-0002 107 µM -0.0139400618122417 0.494481264825941 no 1706 0.494438900062695 2424 6797879 YHR007C ERG11
SGTC_1071 trifluoperazine 6.31 µM -0.0141008171355593 0.49441060806608 no 1707 0.494374774270493 2456 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2708 st078559 56 µM -0.0144061774086073 0.494276393602034 no 1708 0.494252965521387 2430 17250902
SGTC_3036 9090181 49.47 µM -0.0145031935451082 0.494233752404992 no 1709 0.494214265725809 2428 25236586
SGTC_1843 st055809 45.5 µM -0.0147717072429029 0.494115733769783 no 1710 0.494107155734252 2481 16413835
SGTC_251 melphalan 456.522 µM -0.0154947448725114 0.493797942835441 no 1711 0.493818738487523 2441 460612 A DNA alkylator.
SGTC_2957 9076800 11.52 µM -0.0157767464593732 0.493673997993994 no 1712 0.493706249883009 2449 16459615
SGTC_488 nitrendipine 139 µM -0.0162870793040663 0.493449698960546 no 1713 0.493502682698719 2421 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_789 1309-1135 70.6 µM -0.0165157768692044 0.493349183576181 no 1714 0.49341145784164 2431 3092424
SGTC_2329 6138490 200 µM -0.0170111852116307 0.493131446991208 no 1715 0.493213846277591 2523 720019
SGTC_2094 5332512 191.667 µM -0.0172597741128623 0.493022190618629 no 1716 0.493114688213402 2449 755774
SGTC_2942 9052777 62.25 µM -0.0175560053888605 0.492891995809419 no 1717 0.492996526937896 2446 6469503
SGTC_3051 9093778 49.47 µM -0.0186062804797818 0.492430401978267 no 1718 0.492577596302945 2438 17217378
SGTC_1300 1094-0077 113 µM -0.0188587038941959 0.492319463872921 no 1719 0.492476911597636 2452 5532636
SGTC_3202 9113761 49.47 µM -0.019201649122008 0.492168743096006 no 1720 0.492340121018504 2457 4798415
SGTC_3203 9113543 49.47 µM -0.0198498458385549 0.491883870610395 no 1721 0.49208157723701 2494 17018012
SGTC_2800 7887935 81.82 µM -0.0199070809761197 0.491858716844664 no 1722 0.492058748231638 2462 2961002
SGTC_2277 7947813 106.88 µM -0.0210278265532357 0.491366176905609 no 1723 0.491611729100432 2568 1246798
SGTC_3298 9116858 71.43 µM -0.0214841641247567 0.491165631567523 no 1724 0.491429717873154 2465 2506942
SGTC_606 k015-0008 38.6 µM -0.0218060057895596 0.491024194092141 no 1725 0.491301351699945 2456 1970475
SGTC_185 k048-0037 25.491 µM -0.0220338248509175 0.490924076745039 no 1726 0.491210486876394 2443 6827589
SGTC_134 0269-0018 6.916 µM -0.0224637018136412 0.490735164610678 no 1727 0.491039033222584 2470 4378915
SGTC_2307 7538926 6.34 µM -0.022775698372462 0.490598057060144 no 1728 0.490914596442599 2460 96582
SGTC_1259 0671-0132 43 µM -0.023086983931703 0.490461263066985 no 1729 0.490790444119058 2467 X1259
SGTC_2693 st077581 40.7 µM -0.0234207531315482 0.490314589917008 no 1730 0.490657325470277 2437 25238761
SGTC_2380 9035439 200 µM -0.0242767879269942 0.489938415884359 no 1731 0.490315914112327 2530 6462575
SGTC_2211 7117706 200 µM -0.0243200221047487 0.489919417387742 no 1732 0.490298671261812 2440 822771
SGTC_2560 caryophyllene 100 µM -0.024713792681883 0.489746382913194 no 1733 0.490141626735986 2460 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1192 1488-0095 21.4 µM -0.025030438496175 0.489607240745988 no 1734 0.490015342400465 2489 915875
SGTC_2012 4023501 200 µM -0.0261016539955324 0.489136531080387 no 1735 0.489588128907809 2451 3477460
SGTC_2897 9048598 12.99 µM -0.026894410364256 0.488788190630905 no 1736 0.48927197589477 2468 6467404
SGTC_3162 9099653 49.47 µM -0.0284760179348107 0.488093251493297 no 1737 0.488641247593412 2467 25237511
SGTC_2 0422-0095 29 µM -0.0285725685675458 0.48805082946849 no 1738 0.488602745130498 2391 6790840
SGTC_2482 5981709 142.65 µM -0.0289941701047276 0.48786558948809 no 1739 0.48843462011181 2496 877755
SGTC_285 1486-1325 46 µM -0.0295457098590732 0.487623262230304 no 1740 0.488214681821246 2475 22310230
SGTC_12 0849-0099 9.267 µM -0.0300130716599656 0.487417923391041 no 1741 0.488028314095223 2457 6071388
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.0300214417483919 0.487414245961466 no 1742 0.488024976417082 2453 2724 A muscle relaxant with antifungal properties.
SGTC_1163 k060-0048 49.9 µM -0.0309887192062804 0.486989276289838 no 1743 0.487639268061408 2449 6809982
SGTC_936 3005-4620 401 µM -0.0312455218896566 0.486876453469738 no 1744 0.487536868201195 2461 777207
SGTC_1939 st074455 53.6 µM -0.0316997921639092 0.486676878485909 no 1745 0.487355730316928 2462 1644229
SGTC_323 4013-0906 34.3 µM -0.0327795093996508 0.486202538786566 no 1746 0.486925209280486 2509 2910086
SGTC_778 3456-2434 196 µM -0.032787747192757 0.486198919846272 no 1747 0.486921924642103 2514 5539063
SGTC_1372 2752-0194 270 µM -0.0338014003858503 0.485753621194482 no 1748 0.486517759619353 2472 823334
SGTC_1483 3453-0561 55.9 µM -0.0338090311734112 0.485750269050124 no 1749 0.486514717114535 2503 4546991
SGTC_3152 9099253 49.47 µM -0.0344036341227977 0.485489067812726 no 1750 0.486277642788968 2497 25236131
SGTC_977 1348-1378 135 µM -0.035034629238009 0.485211886788194 no 1751 0.486026063837569 2454 X977
SGTC_176 1486-1328 72.834 µM -0.0355649831455461 0.48497892055412 no 1752 0.485814615024481 2509 22310231
SGTC_1291 0993-0025 5.79 µM -0.0355682092339585 0.484977503460025 no 1753 0.485813328815186 2492 4353356
SGTC_1792 st045773 43.6 µM -0.0356019453407767 0.484962684522984 no 1754 0.485799878574502 2478 2919270
SGTC_1474 0330-0125 5.35 µM -0.036204800945335 0.484697877427217 no 1755 0.485559528950044 2483 X1474
SGTC_3289 9119912 71.43 µM -0.0371436262127122 0.484285507593494 no 1756 0.48518524366184 2501 17014829
SGTC_1633 st005664 67.9 µM -0.0375652676814284 0.484100311137291 no 1757 0.485017150369846 2472 2063822
SGTC_1676 st018489 23.4 µM -0.0396522695519391 0.483183694157806 no 1758 0.484185177551175 2523 3696235
SGTC_2791 5663188 71.43 µM -0.0399175249784845 0.483067199507306 no 1759 0.484079439662829 2515 54690634
SGTC_46 0329-0187a 2.197 µM -0.0405669117881859 0.482782008487434 no 1760 0.483820581499663 2482 46494817
SGTC_1189 1431-2119 7.28 µM -0.0406335559414211 0.482752740889657 no 1761 0.48379401623304 2471 3107275
SGTC_2638 epoxomicin 18 µM -0.0410378344395348 0.482575199023451 no 1762 0.483632866866847 2519 9915668 A protesome inhibitor.
SGTC_2678 equilin 100 µM -0.0412767159012698 0.482470294100105 no 1763 0.483537647633089 2463 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0413029120957693 0.482458790100811 no 1764 0.483527205768213 2530 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3335 9143315 29.6265 µM -0.0415409733358936 0.482354246718724 no 1765 0.483432314515485 2503 4899691
SGTC_2648 atorvastatin 78.68 µM -0.0417598029248563 0.482258149888453 no 1766 0.483345089829962 2479 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3204 9114183 49.47 µM -0.0420361879655135 0.482136779629718 no 1767 0.483234924888456 2475 17027248
SGTC_1882 5615643 20 µM -0.0421459653066587 0.482088573049954 no 1768 0.483191168843227 2470 2253075
SGTC_1942 st076330 65.2 µM -0.0425173102109877 0.481925506118258 no 1769 0.483043156337361 2575 24208414
SGTC_2843 9000894 45.46 µM -0.0450857319102245 0.480797731501073 no 1770 0.482019487072127 2474 2242070
SGTC_2166 5933061 31.504 µM -0.0452873490306326 0.480709209330252 no 1771 0.481939135552176 2625 2877375
SGTC_1658 st012944 20 µM -0.0456546989690798 0.480547922827209 no 1772 0.481792735558449 2523 24207260
SGTC_576 1073-0113 22.7 µM -0.0458256030719961 0.480472887760877 no 1773 0.481724625971388 2491 5439563
SGTC_1348 1493-0373 93.8 µM -0.0458470847469694 0.480463456328145 no 1774 0.481716065020864 2514 3010129
SGTC_690 glyoxal 20.3 µM -0.0463006825899149 0.480264308798158 no 1775 0.481535297633177 2497 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2418 pentamidine 31.67 µM -0.0469962476776237 0.479958937590047 no 1776 0.481258109072776 2469 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3066 9117245 49.47 µM -0.0475859257731712 0.479700062737302 no 1777 0.481023124464304 2508 17176980
SGTC_1471 k673-0312 37 µM -0.0478322982462703 0.479591905174004 no 1778 0.480924947864704 2502 24099884
SGTC_1824 st053723 68.6 µM -0.0481657168784831 0.479445536724264 no 1779 0.480792086214334 2513 675225
SGTC_133 0724-0033 378.92 µM -0.0499981660519238 0.478641154344772 no 1780 0.480061924887111 2488 280309
SGTC_1246 0422-0085 105 µM -0.0505663939508839 0.478391739290245 no 1781 0.479835521146495 2508 264295
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.0512669148366063 0.478084267884239 no 1782 0.479556415778291 2500 3256 An antibiotic and ribosome inhibitor.
SGTC_1989 st071868 50.2 µM -0.0513491113402255 0.478048191189677 no 1783 0.479523667251535 2490 16414057
SGTC_1324 1418-0026 34.4 µM -0.0515821144910564 0.477945925245344 no 1784 0.479430835467063 2585 1372513
SGTC_2472 5377652 49.4 µM -0.0520749903913734 0.477729604983464 no 1785 0.479234470348491 2523 1610903
SGTC_1957 st077035 62.4 µM -0.0521560946144418 0.477694009455788 no 1786 0.479202158354775 2514 705593
SGTC_2983 9022671 12.99 µM -0.0522627580305739 0.477647196620868 no 1787 0.479159663764205 2625 6405161
SGTC_1706 st031321 9.9705 µM -0.0545970435526959 0.476622795105903 no 1788 0.478229747075318 2513 6103185
SGTC_3271 9137798 49.47 µM -0.054849586290928 0.476511975830889 no 1789 0.478129147841826 2503 6498326
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.0549585766079552 0.476464149920672 no 1790 0.478085732482462 2488 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2636 apigenin dimethyl ether 100 µM -0.0556359558104433 0.476166917593949 no 1791 0.477815910129124 2580 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1305 1181-0477 144 µM -0.0556806715686239 0.4761472968941 no 1792 0.477798098732463 2544 6252086
SGTC_2246 7293507 91.5585 µM -0.05636501771963 0.475847021844404 no 1793 0.47752551222396 2558 887656
SGTC_636 0kpi-0074 126 µM -0.0564749548833037 0.475798785268225 no 1794 0.477481723391329 2561 616434
SGTC_2507 purpurin 79.67 µM -0.056579781307055 0.475752791436007 no 1795 0.477439970459604 2498 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1392 3455-1037 33.9 µM -0.0568694404217554 0.475625701758013 no 1796 0.477324598956016 2582 981132
SGTC_372 0155-0182 15.9 µM -0.0571785321654477 0.4754900886324 no 1797 0.47720148951387 2512 771486
SGTC_490 phenamil 164 µM -0.0573244323667749 0.475426076318474 no 1798 0.477143379068214 2557 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_34 0469-0683 81.75 µM -0.0573700012738893 0.475406083527464 no 1799 0.477125229573199 2571 3690923
SGTC_2860 9025725 38.96 µM -0.0581812915638129 0.475050150419314 no 1800 0.476802111322457 2531 40546248
SGTC_159 3970-0959 50 µM -0.0590612846184689 0.474664098230386 no 1801 0.476451647591911 2564 6615653
SGTC_2056 5235370 200 µM -0.0593714678949159 0.474528026747878 no 1802 0.476328119139884 2549 5511916
SGTC_249 wiskostatin 11.211 µM -0.0597342447746615 0.4743688872264 no 1803 0.476183648517885 2496 2775510 A n-wasp and actin depolymerizer.
SGTC_1408 3909-7976 48.8 µM -0.0602204928422807 0.474155590954009 no 1804 0.475990012202742 2536 24152374
SGTC_329 k048-0121 21.3 µM -0.0607195280176146 0.473936693226843 no 1805 0.475791289632967 2569 6832902
SGTC_2143 5623677 140.463 µM -0.0607462498465444 0.473924972134954 no 1806 0.47578064880796 2496 5375313
SGTC_2497 7-hydroxyflavone 100 µM -0.064230961673173 0.472396657602474 no 1807 0.474393162218914 2608 5281894
SGTC_3002 9075603 71.4286 µM -0.0650112193367226 0.472054509397159 no 1808 0.474082533707269 2518 20105405
SGTC_849 0386-0493 241 µM -0.0652658194447659 0.471942869996515 no 1809 0.473981178215132 2526 726119
SGTC_2806 7952793 58.44 µM -0.0654663732687101 0.47185493086006 no 1810 0.473901339562087 2595 2972490
SGTC_1281 0884-0031 11.8 µM -0.0658376252647155 0.471692147361447 no 1811 0.473753550288046 2530 1548255
SGTC_830 4076-0286 57.8 µM -0.0672224441873423 0.471084985371823 no 1812 0.473202308829041 2554 6866659
SGTC_113 0099-0221 2.5 µM -0.0673108255098389 0.471046237604811 no 1813 0.473167129462612 2522 89219
SGTC_953 1188-0045 9.7 µM -0.0678126332466632 0.470826242378155 no 1814 0.472967393518521 2595 6144426
SGTC_2426 5582046 32.21 µM -0.0693119587308809 0.470168983277899 no 1815 0.472370653470496 2592 2251934
SGTC_2232 chlorophetanol 41.5365 µM -0.0710572036442875 0.469404022983481 no 1816 0.471676114287849 2547 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2187 6125751 200 µM -0.0721567838641457 0.468922122524861 no 1817 0.471238568480189 2568 874498
SGTC_561 1550-0330 72.9 µM -0.0752135655133439 0.467582703149858 no 1818 0.470022395604489 2564 6812934
SGTC_2144 5628481 200 µM -0.0757227385226973 0.467359629165309 no 1819 0.46981984260172 2548 2818399
SGTC_1323 1348-1351 11.2 µM -0.076826923571806 0.466875909536833 no 1820 0.469380616059664 2545 6989654
SGTC_2022 5136654 200 µM -0.0772803254351403 0.466677298097277 no 1821 0.469200271061032 2637 1713771
SGTC_2435 5706476 10.6 µM -0.0775821789569793 0.466545076589721 no 1822 0.469080209389968 2564 5725375
SGTC_638 3970-0837 4.09 µM -0.0780423629236862 0.466343508387547 no 1823 0.46889717749622 2571 4118451 YLR208W SEC13
SGTC_787 4152-0075 138 µM -0.0784798826487357 0.46615187550325 no 1824 0.468723166090391 2580 9566539
SGTC_1527 coumarin 137 µM -0.0791358297575184 0.465864586517675 no 1825 0.468462292419984 2772 323 A hepatotoxic, DNA x-linker.
SGTC_1473 k844-0725 134 µM -0.0791468752259613 0.46585974902123 no 1826 0.468457899693778 2551 54682906
SGTC_1453 4237-0541 195 µM -0.079510413798413 0.465700535727659 no 1827 0.468313324412472 2549 739892
SGTC_968 1309-0633 340 µM -0.0801161681879471 0.465435255174473 no 1828 0.468072431864023 2545 3761976
SGTC_2336 9001819 198.65 µM -0.0801946575433987 0.465400883124318 no 1829 0.468041219570584 2617 2989602
SGTC_3100 9120536 49.47 µM -0.0806258130900703 0.465212076143662 no 1830 0.46786976857628 2517 16421196
SGTC_2172 5754775 163.918 µM -0.0812007410511899 0.464960322091082 no 1831 0.467641155095229 2571 2263357
SGTC_503 tyrphostin 8 294 µM -0.0816908742148299 0.46474570973342 no 1832 0.46744626771318 2542 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_274 sirtinol 40.1 µM -0.0820430539127694 0.464591508754494 no 1833 0.467306238381509 2586 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_88 0180-0332 8.668 µM -0.0821531939812128 0.464543285298073 no 1834 0.467262446680683 2526 3101745
SGTC_628 1636-0253 16 µM -0.0823187401934189 0.464470803931997 no 1835 0.4671966262378 2599 4456143
SGTC_3047 9092122 49.47 µM -0.0834623167288331 0.463970142297498 no 1836 0.466741969853235 2601 17173831
SGTC_2162 5663267 200 µM -0.0834679188142709 0.46396768982552 no 1837 0.466739742715616 2550 6456493
SGTC_1798 st045719 60.953 µM -0.0838664470165253 0.463793226307036 no 1838 0.466581308473938 2553 3980186
SGTC_685 1278-0033 54.9 µM -0.0842127863287895 0.46364161514952 no 1839 0.466443626140636 2560 3590572
SGTC_2328 6201408 200 µM -0.0846767099557974 0.463438539354003 no 1840 0.46625920610804 2609 2890418
SGTC_214 4373-3496 70 µM -0.0854329109785904 0.463107543838752 no 1841 0.465958614810455 2589 3779166
SGTC_588 3970-1144 52.9 µM -0.0873198534651669 0.462281725192835 no 1842 0.465208636755543 2656 1888707
SGTC_2034 5197015 53.07 µM -0.0874302061633578 0.462233434432882 no 1843 0.465164780127853 2650 780676
SGTC_593 1203-0218 61.7 µM -0.0877523348249853 0.462092472893687 no 1844 0.465036761423221 2625 3666956
SGTC_1729 st035615 45.989 µM -0.0880804263994598 0.461948906914465 no 1845 0.464906376688548 2705 17385451
SGTC_1096 rimcazole 32.2 µM -0.0884219348166676 0.461799475272953 no 1846 0.464770664056169 2556 18528119 A dopamine reuptake inhibitor.
SGTC_96 0929-0093 37.281 µM -0.088626796843296 0.461709837699904 no 1847 0.464689255539486 2548 6991579
SGTC_1762 st045503 25.4615 µM -0.0889318138467231 0.461576380827343 no 1848 0.464568049960427 2619 4645554
SGTC_919 tnp00227 403.569 nM -0.0895864537122914 0.461289964900763 no 1849 0.464307924744848 2609 1269246 A methoxyflavone. YNL221C POP1
SGTC_2605 digitonin 300 nM -0.0900194964204578 0.461100512473125 no 1850 0.464135860912168 2559 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2536 dehydroabietamide 32.04 µM -0.0903468421505112 0.460957307412945 no 1851 0.464005798835257 2638 3983547
SGTC_2705 st078069 42.8 µM -0.0908989243234665 0.460715797609211 no 1852 0.463786452460567 2637 1530061
SGTC_400 oxethazaine 37.5 µM -0.0915848902970093 0.460415740179955 no 1853 0.463513928393484 2632 4621 A local anesthetic.
SGTC_2385 9074692 200 µM -0.092126007889431 0.460179058686855 no 1854 0.463298962504558 2591 17046906
SGTC_1741 st038134 10.228 µM -0.0922871937299191 0.460108559719165 no 1855 0.463234931435144 2670 1272587
SGTC_1561 5-methoxyflavone 52.9 µM -0.0922957986618242 0.460104796155727 no 1856 0.463231513153016 2554 94525
SGTC_791 1348-1292 225 µM -0.0923610791508494 0.460076244359804 no 1857 0.46320558077257 2658 5437054
SGTC_577 r071-0003 38.6 µM -0.0936169867287054 0.459526986997186 no 1858 0.462706707709218 2572 4568517 YMR134W ERG29
SGTC_2940 9060638 45.86 µM -0.0936866504027568 0.459496522607079 no 1859 0.462679037533585 2645 4027022
SGTC_1443 4112-3303 14 µM -0.0940301548443509 0.459346309300593 no 1860 0.462542601374797 2569 704433
SGTC_75 0159-0059 199.013 µM -0.0966574145792759 0.458197611191809 no 1861 0.461499229829302 2670 5377270
SGTC_2886 9058944 51.95 µM -0.0976378973337106 0.457769010604796 no 1862 0.461109915270801 2557 4949929
SGTC_2965 9082772 38.63 µM -0.0979112822768284 0.457649513975651 no 1863 0.461001370537277 2627 16459634
SGTC_2046 4110841 106 µM -0.0983182333476589 0.45747164265169 no 1864 0.460839800104116 2611 44119630 YMR134W ERG29
SGTC_2526 patulin 37.61 µM -0.0986590428191347 0.457322687237476 no 1865 0.460704494623358 2670 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3142 9086498 49.47 µM -0.0997910298588474 0.45682798004879 no 1866 0.460255114818967 2610 25236367
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0998917563971494 0.456783963214302 no 1867 0.460215130529336 2770 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3220 9131269 49.47 µM -0.10014988309264 0.45667116596851 no 1868 0.46011266669362 2557 17722206
SGTC_1664 st014217 9.02 µM -0.100330981547136 0.456592030917885 no 1869 0.460040780931326 2598 3982782
SGTC_2745 rifampicin 24.3 µM -0.101924303110064 0.455895867707838 no 1870 0.459408379662573 2661 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2944 9067346 25.62 µM -0.10240567910021 0.455685568676822 no 1871 0.459217338051453 2671 6473075
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.102959914783675 0.455443454765836 no 1872 0.458997392594333 2565 6708784 An antioxidant flavonoid
SGTC_1923 st058458 19.1 µM -0.103999645491315 0.454989300519871 no 1873 0.458584814951369 2689 3534982
SGTC_1692 fluoroquinolonic acid 71 µM -0.104329095270189 0.454845409141059 no 1874 0.458454094605046 2700 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3031 9088762 49.47 µM -0.104546555809435 0.454750433731054 no 1875 0.458367812239308 2580 205253
SGTC_1802 st050112 57.9 µM -0.104562546682611 0.454743449854562 no 1876 0.458361467577668 2559 4662563
SGTC_48 0382-0018 55 µM -0.105913470261723 0.454153496313105 no 1877 0.457825503230394 2684 762596
SGTC_2763 lisinopril 49.32 µM -0.107476948265959 0.453470845769739 no 1878 0.457205306000133 2580 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2998 9066762 71.4286 µM -0.10762627820226 0.453405652036539 no 1879 0.45714607553717 2688 4945196
SGTC_2396 5342950 42.78 µM -0.108540380882178 0.453006604993635 no 1880 0.456783525196403 2646 1886677
SGTC_359 0081-0058 15.9 µM -0.108960665771114 0.452823147586061 no 1881 0.456616844345811 2858 3494159
SGTC_1908 st060353 56.5 µM -0.109334906341233 0.452659797332455 no 1882 0.456468430642377 2698 4227716
SGTC_3315 9136395 68.55 µM -0.1105184632829 0.452143245792781 no 1883 0.455999103990517 2610 16876844
SGTC_1123 mangostin 811.285 nM -0.111696626823736 0.451629128591419 no 1884 0.455531976999443 2697 5281650 An antioxidant.
SGTC_3163 9099914 49.47 µM -0.112128875083403 0.451440527986622 no 1885 0.455360611392652 2612 16268368
SGTC_1158 4092-0494 91.8 µM -0.112490029324 0.451282955863213 no 1886 0.455217437506123 2734 1148199
SGTC_657 3534-0529 86.7 µM -0.112804202478679 0.4511458878986 no 1887 0.455092893258132 2727 1049549
SGTC_1203 3992-3522 103 µM -0.11302836188044 0.451048094837327 no 1888 0.455004034880913 2835 5322312
SGTC_1770 st043884 66.3 µM -0.113743911083385 0.450735945162947 no 1889 0.454720401185259 2607 670149
SGTC_2829 7992743 58.44 µM -0.113894183107561 0.45067039467686 no 1890 0.454660838384889 2697 16462845
SGTC_2397 5161689 200 µM -0.114851743388814 0.450252726904301 no 1891 0.45428131754184 2729 2259942
SGTC_1405 3909-7894 12 µM -0.115226907334493 0.450089103230653 no 1892 0.454132635874934 2698 7104060
SGTC_3072 9116419 49.47 µM -0.115419997707915 0.450004892270076 no 1893 0.4540561145047 2672 17170162
SGTC_2948 9070189 9.45 µM -0.115663225359109 0.449898818543729 no 1894 0.45395972624823 2679 6473636 YDL196W YDL196W
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.116549949350562 0.449512140749132 no 1895 0.453608350967669 2624 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2928 9011484 9.79 µM -0.116773099265612 0.449414838278571 no 1896 0.453519930779236 2694 2994751
SGTC_2082 5219693 150 µM -0.117091045503401 0.449276205998084 no 1897 0.453393952788777 2605 2834649
SGTC_1187 1391-0724 117 µM -0.11828189493921 0.448757021886743 no 1898 0.452922151216745 2645 6997986
SGTC_1315 1237-0019 3.69 µM -0.119371205146332 0.448282183454567 no 1899 0.452490636558257 2677 825140
SGTC_982 1491-0518 27.5 µM -0.121803714978869 0.447222102738222 no 1900 0.451527235866458 2675 3091256
SGTC_2066 5222451 176 µM -0.122265791015244 0.447020773716296 no 1901 0.451344261754888 2622 2281147
SGTC_1244 0416-0015 52.5 µM -0.122615969181783 0.446868208290614 no 1902 0.451205604145934 2649 96201
SGTC_777 1315-0167 517 µM -0.125170633996995 0.445755432707231 no 1903 0.45019423252385 2721 4221767
SGTC_283 0987-0079 11.7 µM -0.125201999182655 0.445741773116004 no 1904 0.450181817290672 2679 411556
SGTC_197 4544-0043 41.561 µM -0.127770788843046 0.44462328098312 no 1905 0.449165183838904 2640 896523
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.127790820064191 0.444614560789365 no 1906 0.449157257512991 2739 616764
SGTC_2659 sanguinarine 24.21 µM -0.127971452162566 0.444535927408922 no 1907 0.449085782563608 2633 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2220 6782180 200 µM -0.128435317955784 0.44433400577925 no 1908 0.448902241453509 2641 833803
SGTC_3044 9093193 49.47 µM -0.129732088684838 0.443769595916098 no 1909 0.44838919700014 2737 25236277
SGTC_2602 kawain 100 µM -0.130014688147782 0.443646611685666 no 1910 0.448277402933865 2581 5369129
SGTC_21 0849-0113 22.993 µM -0.130147305046075 0.443588900115935 no 1911 0.448224942174945 2626 1560156
SGTC_2784 7567673 72.73 µM -0.130396652302636 0.443480393643372 no 1912 0.448126307526932 2612 3471247
SGTC_2085 5307070 144.047 µM -0.132241357443449 0.442677780078685 no 1913 0.447396694921819 2634 2840351
SGTC_2179 6298986 200 µM -0.13389944147067 0.441956564179982 no 1914 0.446741045975468 2731 738374
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.134544229371614 0.441676152958402 no 1915 0.446486119511697 2699 279621
SGTC_486 niguldipine 82 µM -0.135045606603098 0.441458129664781 no 1916 0.446287907862255 2619 1236 A calcium channel blocker.
SGTC_3222 9128301 49.47 µM -0.135962784632853 0.441059341836812 no 1917 0.445925350632882 2684 4911358
SGTC_1414 3917-0015 5.4 µM -0.13627330271452 0.440924342494268 no 1918 0.445802614162994 2655 6618702
SGTC_3119 9125183 49.47 µM -0.136622577129997 0.440772501839243 no 1919 0.445664564935067 2673 22695334
SGTC_2517 totarol 10 µM -0.137305414477855 0.440475675980277 no 1920 0.445394695419318 2702 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2459 5811157 9.22 µM -0.13734465737796 0.440458618309512 no 1921 0.44537918669193 2625 2870684 YBR192W RIM2
SGTC_2887 9044784 58.44 µM -0.138934948395418 0.439767461469462 no 1922 0.444750776975036 2670 6465546
SGTC_408 cantharidin 100 µM -0.13899333161392 0.439742091001781 no 1923 0.444727709250261 2699 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_674 0498-0004 451 µM -0.139602385732397 0.439477440891424 no 1924 0.44448707777059 2692 4231473
SGTC_2956 9076196 2.52 µM -0.13968659341252 0.439440852554589 no 1925 0.44445380972632 2723 16423868
SGTC_3176 9106582 49.47 µM -0.140937841430754 0.438897244928403 no 1926 0.443959523680137 2651 17018027
SGTC_1896 st058441 89 µM -0.141316802224019 0.438732627214135 no 1927 0.443809838281027 2694 688759
SGTC_1019 4262-0212 3.4 µM -0.141810809379754 0.43851805014289 no 1928 0.443614722856588 2650 4677213
SGTC_2130 NSC 7 2.4545 µM -0.142143279826384 0.438373648366635 no 1929 0.443483416433996 2747 21448
SGTC_2812 7970281 58.44 µM -0.142661617237003 0.438148535427781 no 1930 0.443278715791943 2779 2233435
SGTC_2247 cerulenin 830 nM -0.143388209344635 0.43783301158016 no 1931 0.442991797166644 2885 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_3201 9113999 49.47 µM -0.144398917171899 0.437394175769088 no 1932 0.442592735910296 2859 16649224
SGTC_1678 st019265 80.2 µM -0.144643030862881 0.437288196396826 no 1933 0.442496360376383 2783 5367020
SGTC_757 1066-0008 322 µM -0.145407639091705 0.436956278988537 no 1934 0.442194516821633 2820 6842497
SGTC_994 3910-0338 138 µM -0.146057126854317 0.436674370366642 no 1935 0.441938145599506 2802 3479481
SGTC_3195 9113082 49.47 µM -0.146071128412008 0.436668293377346 no 1936 0.441932619055374 2647 17018038
SGTC_852 0418-0143 439 µM -0.14646538552624 0.436497183109961 no 1937 0.441777006775269 2705 5369229
SGTC_2996 9066192 71.4286 µM -0.146656662353635 0.436414171945505 no 1938 0.441701513533801 2708 6472854
SGTC_1751 st044839 27.194 µM -0.14684306570237 0.43633327848911 no 1939 0.44162794579696 2634 5291326
SGTC_263 alizarin 107.927 µM -0.147777592106342 0.435927762296412 no 1940 0.441259147030904 2646 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2081 5214970 32.255 µM -0.14924849590685 0.435289634080985 no 1941 0.440678777143233 2698 2063512
SGTC_1373 2887-0003 58.5 µM -0.149303086614574 0.435265954003173 no 1942 0.440657239903535 2766 776948
SGTC_472 calcifediol 10 µM -0.152060390524614 0.434070208594174 no 1943 0.439569652314742 2746 5283731 A vitamin D metabolite.
SGTC_2068 5226020 147 µM -0.152232591087048 0.433995551179867 no 1944 0.439501744776619 2703 1810509
SGTC_2997 9067075 71.4286 µM -0.152269202452572 0.433979678655418 no 1945 0.439487307261657 2764 27209819
SGTC_1161 k007-0610 110 µM -0.153816968957821 0.433308756259032 no 1946 0.4388770268867 2746 5843850
SGTC_3243 9134147 49.47 µM -0.15567352385924 0.432504234590964 no 1947 0.438145183801359 2693 24282180
SGTC_925 2064-1272 59.6 µM -0.159535442154805 0.430831606330195 no 1948 0.436623518539679 2724 6815817
SGTC_2285 7945142 200 µM -0.15958508602975 0.430810113171921 no 1949 0.436603964014121 2806 2970608
SGTC_2475 5812728 15.03 µM -0.160869712242619 0.4302540097695 no 1950 0.436098008848348 2668 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_643 k048-0106 28.4 µM -0.161337194830774 0.430051674929697 no 1951 0.435913914866154 2803 6763920
SGTC_2029 5175081 200 µM -0.161427486326547 0.430012597267379 no 1952 0.435878359801383 2689 1380876
SGTC_116 0155-0182 31.788 µM -0.162253400959778 0.429655177824503 no 1953 0.435553154495564 2703 771486
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.162650555960607 0.429483327156874 no 1954 0.435396789533931 2826 5282362
SGTC_17 0960-0276 49.807 µM -0.163455449054147 0.42913508748736 no 1955 0.435079923916174 2690 6821114
SGTC_2008 4012253 172 µM -0.163507807904605 0.42911243616437 no 1956 0.435059313031232 2693 603940
SGTC_2155 5570423 76 µM -0.163698138438224 0.429030097928197 no 1957 0.434984391545353 2706 797402
SGTC_297 0986-0032 24 µM -0.164193486535484 0.428815821580916 no 1958 0.434789414256504 2682 2847425
SGTC_2920 7982904 15.77 µM -0.164539251632088 0.428666263874672 no 1959 0.434653324731229 2800 6456808
SGTC_2276 7947513 42.08 µM -0.16532754014271 0.428325334816073 no 1960 0.434343091590357 2790 2105100
SGTC_2346 9031566 143.75 µM -0.16631202041935 0.427899629383347 no 1961 0.43395570342882 2816 4771086
SGTC_1877 wortmannin 25 µM -0.166698234816562 0.427732646826761 no 1962 0.433803747257839 2798 312145 A covalent inhibitor of PI 3-kinase.
SGTC_610 4215-0184 155 µM -0.167480739283365 0.427394365132466 no 1963 0.433495900652461 2768 5605015
SGTC_2870 9038528 12.99 µM -0.167484937293823 0.427392550449372 no 1964 0.433494249213627 2849 6463316
SGTC_333 3486-0131 40.1 µM -0.168196963403432 0.427084783634856 no 1965 0.433214164883878 2846 6744690
SGTC_735 3076-0345 636 µM -0.170081877622293 0.426270261313093 no 1966 0.432472872711108 2842 2888990
SGTC_491 tetrandrine 80.3 µM -0.171137496067494 0.425814237200873 no 1967 0.432057826582538 2800 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_54 0159-0055 9 µM -0.173192744026203 0.42492666115303 no 1968 0.431249963442887 2926 3319099
SGTC_3234 9132280 49.47 µM -0.173495925266741 0.424795761886886 no 1969 0.431130815240771 2780 17612295
SGTC_1841 st054148 70 µM -0.173557047883402 0.424769373046751 no 1970 0.431106795219513 2792 675442
SGTC_1866 st057638 64 µM -0.173633000833089 0.424736581886268 no 1971 0.431076947515607 2736 688802
SGTC_528 3492-0019 172 µM -0.17452240184526 0.42435263967974 no 1972 0.430727463394351 2712 2869262
SGTC_702 1488-0190 94 µM -0.176451828530577 0.423519979876856 no 1973 0.429969495039774 2818 949357
SGTC_2654 protoveratrine a 100 µM -0.176675251896767 0.423423581689246 no 1974 0.429881740587644 2717 5702278 A heart drug and vasodilator.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.176953349338322 0.423303600242923 no 1975 0.429772516526773 2740 279621
SGTC_1055 3448-0672 86 µM -0.176982073675991 0.423291207914113 no 1976 0.429761235215949 2866 748378
SGTC_206 4546-0025 72.014 µM -0.178873910886795 0.42247519421682 no 1977 0.429018354236826 2748 6620745 YIL048W NEO1
SGTC_39 0986-0283 58.349 µM -0.179821592819532 0.422066551602099 no 1978 0.428646315658342 2843 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_67 0335-0847 266 µM -0.180241661193352 0.421885443966406 no 1979 0.428481426536504 3114 4552207 YOR254C SEC63
SGTC_419 nsc-638432 893 µM -0.180694825866256 0.421690085766573 no 1980 0.428303560148217 2804 368090
SGTC_376 3970-0862 59.1 µM -0.180842207369152 0.421626554106085 no 1981 0.428245716287703 2839 3135186
SGTC_1166 k206-0078 225 µM -0.180853241792933 0.421621797585377 no 1982 0.428241385591401 2722 5404595
SGTC_3307 9126885 69.2785 µM -0.181084609764198 0.42152206628134 no 1983 0.428150582259406 2732 24824909
SGTC_1319 1306-0155 43.7 µM -0.18173179723721 0.421243122483896 no 1984 0.427896605442289 2727 3122360
SGTC_3029 9088683 49.47 µM -0.181789011825975 0.421218464365547 no 1985 0.427874154065066 2861 25236615
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.182654708124625 0.42084540774299 no 1986 0.427534477737606 2740 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_271 rotenone 740 µM -0.182817443161747 0.420775287860964 no 1987 0.427470630803249 2854 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1480 1070-0044 41.2 µM -0.184140739881586 0.42020519432489 no 1988 0.426951523545171 2822 3124987
SGTC_2844 9010103 25.97 µM -0.184367274109581 0.42010761716155 no 1989 0.426862670596096 2921 2480525
SGTC_2753 fluvastatin 17.09 µM -0.184733336730482 0.41994995003641 no 1990 0.426719098622458 2816 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2646 retinol 96.75 µM -0.185683001923553 0.419540978935419 no 1991 0.426346679500627 2807 445354 A vitamin A analog and teratogen.
SGTC_208 k072-0098 12.366 µM -0.186059482295541 0.419378872568628 no 1992 0.426199057742392 2736 5948901
SGTC_895 0964-0006 13.7 µM -0.186388136591613 0.419237370522497 no 1993 0.426070197524407 2717 6738897
SGTC_1450 4112-4260 37.6 µM -0.187242811939644 0.418869439154058 no 1994 0.425735129652627 2791 1633175
SGTC_583 1488-1091 88.9 µM -0.187336009471197 0.418829322595729 no 1995 0.425698595626806 2780 4303273
SGTC_2370 9071495 200 µM -0.188848388776724 0.418178442371936 no 1996 0.425105822686372 2808 21791103
SGTC_356 1634-0012 32.5 µM -0.188972154190759 0.41812518754389 no 1997 0.425057320645718 2763 735457
SGTC_538 2922-0838 53.3 µM -0.189400099220093 0.417941059315175 no 1998 0.424889623354631 2791 777039
SGTC_1594 piperine 70.1 µM -0.19321926028184 0.416298622780757 no 1999 0.423393627713806 2751 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2364 9055074 200 µM -0.193319816483438 0.416255398028102 no 2000 0.423354253871293 2837 6470630
SGTC_1661 st013063 9.66 µM -0.19453410811872 0.415733506794568 no 2001 0.422878845699613 2754 721395
SGTC_2921 7974240 10.71 µM -0.194709702069575 0.415658050425799 no 2002 0.422810108065373 2883 2979074 YDR527W RBA50
SGTC_5 0352-0601 109.883 µM -0.196246066981636 0.414997975437665 no 2003 0.422208786387554 2799 762456
SGTC_2357 9067248 200 µM -0.196279706007787 0.414983525636774 no 2004 0.422195622348577 2850 9150235
SGTC_183 3914-0051 30.55 µM -0.196811744450328 0.41475500134445 no 2005 0.42198743006529 2869 1596232
SGTC_1560 lithocholic acid 53.1 µM -0.196876213951628 0.414727311981635 no 2006 0.421962203945572 2747 9903 A bile acid which acts as a detergent.
SGTC_468 gf-109203x 121 µM -0.19846627766435 0.4140445211386 no 2007 0.421340133234196 2847 2396 A protein kinase C inhibitor.
SGTC_1133 3473-0247 50 µM -0.199205184283923 0.413727314779133 no 2008 0.421051122111726 2838 711311
SGTC_1529 apigenin 74 µM -0.199311114311992 0.413681844522772 no 2009 0.421009692813179 2994 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_211 3455-0679 143.504 µM -0.20087716534777 0.413009755547081 no 2010 0.420397311590034 2816 748649
SGTC_2945 9067681 61.76 µM -0.201486317284499 0.412748399669085 no 2011 0.420159163638023 2701 16456930
SGTC_2571 chrysanthemic acid 100 µM -0.202003766952282 0.412526418909719 no 2012 0.419956889643838 2820 2743 An insecticide.
SGTC_1974 st069448 26.9 µM -0.204161329246765 0.411601148435053 no 2013 0.419113714822787 2908 6323587 YNR016C ACC1
SGTC_589 1227-0070 34.1 µM -0.204743624713773 0.411351515043658 no 2014 0.41888621737046 2894 2841384
SGTC_694 1315-0438 43.2 µM -0.205720835324447 0.410932659969826 no 2015 0.418504491210755 2819 6793154
SGTC_987 1497-1013 404 µM -0.205925648027392 0.410844885361451 no 2016 0.4184244952791 2760 1676435
SGTC_2984 9022109 38.96 µM -0.207210488663532 0.410294355591054 no 2017 0.417922738153743 2825 6459207
SGTC_87 0100-0052 35.5 µM -0.208258458892708 0.409845451094362 no 2018 0.417513582737608 2810 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1245 0418-0076 17.2 µM -0.209733919837411 0.409213628704434 no 2019 0.416937675039622 2955 6790114
SGTC_969 1313-0238 134 µM -0.210138871538532 0.409040261314699 no 2020 0.416779643818009 2781 5212874
SGTC_2847 9005661 71.43 µM -0.210662942604244 0.408815923116168 no 2021 0.416575146577465 2779 2991449
SGTC_403 arphamenine a 50 µM -0.21144638210616 0.408480613241431 no 2022 0.416269483558245 2777 5487158 An arginine aminopeptidase inhibitor.
SGTC_520 3584-0023 682 µM -0.212038982348551 0.40822702651202 no 2023 0.416038311097507 2837 1340790
SGTC_2663 amphotericin b 100 µM -0.213350315150666 0.407666015004625 no 2024 0.415526865512394 2793 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2698 st077697 67.5 µM -0.213519520440738 0.407593639734973 no 2025 0.415460882524774 2834 3154499
SGTC_663 1486-0733 13.9 µM -0.214261770119538 0.407276189788722 no 2026 0.415171464376646 2785 722445 YPR165W RHO1
SGTC_2650 prasterone 100 µM -0.214840703634676 0.407028630170341 no 2027 0.414945758441344 2778 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2610 ononetin 44.17 µM -0.214866080304913 0.40701777961988 no 2028 0.414935865606578 2854 259632
SGTC_2913 7966556 36.57 µM -0.214869700018814 0.40701623190931 no 2029 0.414934454502614 2834 2976516
SGTC_1263 0774-1208 64.8 µM -0.21569575606993 0.40666306641413 no 2030 0.414612454761067 2916 906585
SGTC_986 1493-0483 84 µM -0.216620711853077 0.406267708191312 no 2031 0.414251971625078 2822 40079
SGTC_137 0438-0332 85.389 µM -0.216695641214669 0.406235684958433 no 2032 0.414222772553657 2781 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2363 9053361 176 µM -0.217410990028547 0.405929991531393 no 2033 0.413944033611979 2941 6469797 YMR079W SEC14
SGTC_416 estradiol valerate 100 µM -0.217458016998539 0.405909897278537 no 2034 0.413925710854748 2845 13791 A steroid.
SGTC_366 0181-0206 4.31 µM -0.219554734587671 0.405014239074506 no 2035 0.413108973863978 2950 274874
SGTC_1982 st072467 71.9 µM -0.21992618192669 0.404855619043356 no 2036 0.412964322620387 2749 3163533
SGTC_2861 9024595 19.48 µM -0.220034851130205 0.404809216732118 no 2037 0.412922006242713 2839 16482810
SGTC_1025 k007-0731 70 µM -0.221257447594162 0.404287254117447 no 2038 0.412445990383529 2794 6256118
SGTC_2911 7942208 15.64 µM -0.223492709323014 0.403333395720989 no 2039 0.411576028380539 2900 1243384
SGTC_213 1246-0773 967 nM -0.224113080896741 0.403068764790526 no 2040 0.411334657132957 2830 6251622
SGTC_204 PMA1.184 62.41 µM -0.225436349323676 0.402504448717773 no 2041 0.41081991832788 2780 2252213 YGL008C PMA1
SGTC_1719 st032227 49.2 µM -0.22761914155385 0.401574027690999 no 2042 0.409971168866331 2833 3125804
SGTC_890 0929-0006 47.2 µM -0.228803547180901 0.401069404688537 no 2043 0.409510804834651 2819 1378169
SGTC_687 k029-0044 34.9 µM -0.229814575235731 0.400638780723812 no 2044 0.409117929215177 2954 5829338
SGTC_1891 st059073 26.2 µM -0.229866276336536 0.40061676307867 no 2045 0.409097841122619 3009 688754
SGTC_1567 st069303 68.4 µM -0.230962603260973 0.400149951195276 no 2046 0.408671927430924 2924 5581319
SGTC_2205 7238770 200 µM -0.231225865374635 0.400037876388787 no 2047 0.408569668375024 2947 279867
SGTC_3354 9151612 71.43 µM -0.231268189517051 0.400019859106191 no 2048 0.408553228964401 2957 27261949
SGTC_1526 st051518 75 µM -0.232364894747245 0.399553068718663 no 2049 0.408127306345689 2871 673993
SGTC_703 3875-0075 71.8 µM -0.23243899738641 0.39952153359965 no 2050 0.408098531336261 2843 2850814
SGTC_1992 st073643 23.3 µM -0.232713038351684 0.399404918422896 no 2051 0.407992122005806 2775 3161292
SGTC_2292 7671323 168.05 µM -0.232911111320024 0.39932063619493 no 2052 0.407915215057777 2968 937504
SGTC_729 4092-0585 94.1 µM -0.233262617777022 0.399171077883711 no 2053 0.407778742329798 2793 2169061
SGTC_2320 7373003 200 µM -0.234620759463251 0.398593357534168 no 2054 0.407251547764527 2861 5415828
SGTC_224 benfluorex 43.875 µM -0.234930155914295 0.398461778852357 no 2055 0.407131471728836 2924 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3012 9080433 71.4286 µM -0.235281207585463 0.398312499211226 no 2056 0.406995239969917 2915 17688859
SGTC_3279 9140807 49.47 µM -0.235451199881978 0.398240217794191 no 2057 0.406929275519812 2789 45595718
SGTC_2727 riluzole 51.77 µM -0.236278534977117 0.397888481433617 no 2058 0.406608271024021 2815 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2801 7907800 81.82 µM -0.236630607886153 0.397738824983114 no 2059 0.406471686402307 2916 6620925
SGTC_2197 6588183 93.1375 µM -0.240156659187138 0.396240831643944 no 2060 0.405104405740143 2848 884136
SGTC_1573 oleylamine 1.06 µM -0.24056080237305 0.396069234450464 no 2061 0.404947766623964 2808 5356789 An amine of the fatty acid oleic acid.
SGTC_1200 1643-0193 18.4 µM -0.240747797176384 0.395989844195851 no 2062 0.404875295728004 2841 5403974
SGTC_2398 5228213 48.84 µM -0.241032634836996 0.39586892220483 no 2063 0.40476491154854 3028 80771 YMR134W ERG29
SGTC_3244 9134489 49.47 µM -0.241715418916442 0.395579101038941 no 2064 0.404500340610482 2901 16584271
SGTC_2715 st079500 56.4 µM -0.241785302279685 0.395549440921722 no 2065 0.404473264076146 2801 28246688
SGTC_1229 0139-0193 12.2 µM -0.242591481860372 0.395207323428371 no 2066 0.404160940312054 2965 3090752
SGTC_2891 9063876 19.48 µM -0.242852643379024 0.395096511923843 no 2067 0.404059776255072 2946 6472478
SGTC_2083 5306046 65.942 µM -0.242907293377207 0.395073324862039 no 2068 0.404038607732191 2860 539837
SGTC_1718 roemerine 11.9335 µM -0.243644471656285 0.394760589037349 no 2069 0.40375309128687 2970 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3259 9138485 49.47 µM -0.243984940848503 0.394616173428823 no 2070 0.403621241499492 3132 17646153
SGTC_1182 1222-0449 220 µM -0.24410103489001 0.394566933541204 no 2071 0.403576285530603 2900 658318
SGTC_1997 st073024 93.8 µM -0.2452087820359 0.394097180773548 no 2072 0.403147388426239 2962 686268
SGTC_1759 st043059 70 µM -0.245509101059622 0.393969853587907 no 2073 0.403031131074852 2838 669426
SGTC_178 4092-0806 87.505 µM -0.245877959638383 0.393813482983912 no 2074 0.402888352911397 2904 2169044
SGTC_980 1473-0395 201 µM -0.246029074220686 0.393749425762768 no 2075 0.402829863059233 2827 768876
SGTC_2017 5132927 60.65 µM -0.247054165133896 0.393314967406592 no 2076 0.402433152627279 2855 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_57 miconazole 162.5 nM -0.247060963252486 0.393312086642024 no 2077 0.402430522088609 2793 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2882 9058044 58.44 µM -0.247152816539208 0.393273163549266 no 2078 0.402394979802218 2940 18076804
SGTC_1014 4130-3005 69.3 µM -0.24910080135152 0.392447951206096 no 2079 0.401641404801641 2829 743608
SGTC_2586 curcumin 80 µM -0.249793324887167 0.392154698159305 no 2080 0.401373591057759 2959 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_733 4069-0007 56.1 µM -0.250961950676465 0.391659975841968 no 2081 0.400921763439694 2865 5717425 YNL287W SEC21
SGTC_893 0958-0369 48.9 µM -0.251228839109741 0.391547016683372 no 2082 0.400818594510551 2990 6819948
SGTC_1181 1222-0449 220 µM -0.251982170740757 0.391228222301955 no 2083 0.400527422462327 3035 658318
SGTC_1955 wogonin 32.4 µM -0.252409710320694 0.391047328869056 no 2084 0.400362197668719 3082 5281703 A flavanone.
SGTC_574 1315-0397 40 µM -0.252715134900269 0.390918117133176 no 2085 0.400244175739592 2843 6794277
SGTC_832 4083-0019 164 µM -0.253092703527451 0.390758401061842 no 2086 0.400098288555534 2981 1990758
SGTC_2544 sphondin 68.51 µM -0.253548669684866 0.390565546458044 no 2087 0.399922128257621 3070 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1590 st077108 57.8 µM -0.253926653931504 0.39040569534404 no 2088 0.399776111326742 2948 5489485
SGTC_1276 0871-0068 94.2 µM -0.254572326290661 0.390132680672699 no 2089 0.399526717759472 2950 3414906
SGTC_3338 9144300 39.5675 µM -0.255440385068641 0.389765718028238 no 2090 0.39919149115123 2929 4901274
SGTC_1366 1683-0113 21.9 µM -0.256325583101412 0.389391611114877 no 2091 0.398849722253392 2854 708623
SGTC_795 0685-0265 78 µM -0.256604163936548 0.389273897045657 no 2092 0.398742180129908 2851 302754
SGTC_123 0083-0120 66.675 µM -0.258387892965424 0.388520425267057 no 2093 0.398053779724919 2865 16001701
SGTC_2855 9016525 58.44 µM -0.258712593173328 0.388383312439225 no 2094 0.397928501173679 2827 43811474
SGTC_2854 9024559 71.43 µM -0.258834983060114 0.388331633840197 no 2095 0.397881282413649 2953 3163529
SGTC_2461 5755302 26.15 µM -0.259741879177874 0.38794876254044 no 2096 0.397531443046113 3007 2788904
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.259840400132978 0.387907175743331 no 2097 0.397493443089574 3059 94937 An inhibitor of serotonin biosynthesis.
SGTC_611 3453-1652 23.7 µM -0.259905716226797 0.387879605798218 no 2098 0.397468250927204 2969 1560575
SGTC_3079 9117512 49.47 µM -0.260029512354496 0.387827352962051 no 2099 0.397420504417596 2834 7185044
SGTC_1700 st030840 7.9285 µM -0.261435645842096 0.387233983939979 no 2100 0.396878285590294 2965 5499307
SGTC_776 4476-4378 112 µM -0.263034090238929 0.38655978228142 no 2101 0.396262151888743 2960 2892008
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.264487957479317 0.385946858421981 no 2102 0.395701971534264 2908 6708561
SGTC_924 2046-0044 21.3 µM -0.264609567220964 0.385895602854631 no 2103 0.395655124602264 2835 3623589
SGTC_2051 5263410 176 µM -0.264879562962079 0.385781813295991 no 2104 0.395551121283812 2899 227584
SGTC_2092 5303694 80.6725 µM -0.266693009666403 0.385017792301749 no 2105 0.394852768263654 2889 1963699
SGTC_1176 0848-0131 83.3 µM -0.266727761391431 0.385003155443158 no 2106 0.394839388766611 2975 6769040
SGTC_912 3474-0017 2.18 µM -0.267496862502421 0.3846792646028 no 2107 0.394543314774953 3055 3360550
SGTC_2681 menadione 3.18 µM -0.267608769899298 0.384632143845272 no 2108 0.394500239854863 2961 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2718 lomofungin 53.02 µM -0.267634155358836 0.384621455047391 no 2109 0.394490468771036 3052 5351222 A RNA synthesis inhibitor.
SGTC_869 0564-0080 44.1 µM -0.267972064225113 0.384479183546651 no 2110 0.394360411039281 2920 6843321
SGTC_1322 1348-1070 12 µM -0.270799781558605 0.383289226841863 no 2111 0.393272513946278 2922 6758089
SGTC_507 nimesulide 162 µM -0.27142237892033 0.383027373551944 no 2112 0.393033095973779 3079 4495 A COX2 inhibitor.
SGTC_3316 9136639 10.545 µM -0.272037856069923 0.382768567424295 no 2113 0.392796455821188 2981 4903665
SGTC_1074 carmofur 3.8 µM -0.274134731279724 0.38188723179288 no 2114 0.391990542048045 2891 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1461 k072-0203 53.8 µM -0.274574108818269 0.381702634815117 no 2115 0.391821730106124 2874 5418714
SGTC_1511 0906-3109 28.5 µM -0.274838764811875 0.381591457092372 no 2116 0.391720057236759 2873 2882180
SGTC_384 k007-0144 5.16 µM -0.27488101479748 0.381573709457452 no 2117 0.391703826747924 2946 6824886
SGTC_2943 9068529 45.32 µM -0.276150906862796 0.381040391773348 no 2118 0.391216081093385 2869 3270634
SGTC_1351 1496-0003 46.5 µM -0.276982151639083 0.380691415432967 no 2119 0.390896905555978 3024 3891978
SGTC_334 1502-1024 68.5 µM -0.277823981101082 0.380338094298812 no 2120 0.390573740674013 2977 3296216
SGTC_688 0527-0193 473 µM -0.278043809105484 0.380245847522548 no 2121 0.390489364650273 2918 4007154
SGTC_1727 st034309 9.9045 µM -0.278296045965358 0.380140009357926 no 2122 0.390392555571752 3160 870305
SGTC_930 2810-3379 265 µM -0.278720872350213 0.379961773207547 no 2123 0.390229521605961 3100 1015764
SGTC_3028 9087778 49.47 µM -0.279499307086287 0.379635246652048 no 2124 0.389930834852402 2884 17217395
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.279631662680187 0.379579736569536 no 2125 0.389880056241042 3094 688751
SGTC_2493 resveratrol 26.09 µM -0.281760718856058 0.378687149850075 no 2126 0.389063496425963 2872 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1148 3909-7663 27.7 µM -0.281877739367802 0.378638108811269 no 2127 0.389018629555948 3035 4084526
SGTC_2309 7664088 163.95 µM -0.282343499702665 0.37844293701626 no 2128 0.388840066917274 3083 704922
SGTC_1803 st050068 52.4 µM -0.283051775383277 0.378146201246002 no 2129 0.388568574049932 2937 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2697 mebhydrolin 72.4 µM -0.284245610442103 0.377646200585397 no 2130 0.388111082111148 3056 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1119 parthenolide 318.541 nM -0.286978274561893 0.376502481983319 no 2131 0.387064477635219 3119 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2688 kanamycin b 96.69 µM -0.289511499562797 0.375443203106964 no 2132 0.38609499056499 3058 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2113 5491891 107.031 µM -0.28953604092597 0.375432945607723 no 2133 0.386085601840501 2928 789979
SGTC_910 3454-3003 490 µM -0.289749816904086 0.375343597860761 no 2134 0.386003820951347 3040 820824
SGTC_385 1494-0393 12.4 µM -0.289884412298187 0.375287347097409 no 2135 0.385952333522201 2952 3090647
SGTC_514 4466-0038 2.65 nM -0.28993292978033 0.375267071084877 no 2136 0.385933774386889 2951 5722064
SGTC_2821 7996764 71.43 µM -0.29039497465059 0.375073994507003 no 2137 0.385757043898583 3147 2987135
SGTC_1028 k015-0029 4.8 µM -0.290439955663935 0.375055199778273 no 2138 0.385739840089979 2904 4588309
SGTC_1847 st056231 15 µM -0.290677158112566 0.37495609274258 no 2139 0.385649121407467 2913 5393180
SGTC_1960 st011366 51.8 µM -0.291515167202141 0.374606025083595 no 2140 0.385328672804217 2890 3972846
SGTC_3221 9128209 49.47 µM -0.292759807299304 0.37408628324216 no 2141 0.384852875971758 2956 16460723
SGTC_3097 9117246 49.47 µM -0.293557844505016 0.373753155960115 no 2142 0.384547896150685 2909 16423892
SGTC_100 0086-0128 49.5915 µM -0.294155791530808 0.373503614754146 no 2143 0.38431943008213 2960 93297
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.295606113653721 0.37289857238247 no 2144 0.383765452088567 2976 688664
SGTC_708 3448-5400 146 µM -0.297549887076272 0.372088164699726 no 2145 0.383023363599094 3022 3462195
SGTC_763 3453-1109 128 µM -0.29998267962522 0.371074670913558 no 2146 0.38209518360811 3093 1560353
SGTC_268 camptothecin 39.6153 µM -0.300108343997894 0.371022343738979 no 2147 0.38204725740198 3014 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_886 0866-0150 153 µM -0.300264770373492 0.370957210468632 no 2148 0.381987601628261 3110 271463
SGTC_2376 9072922 81.32 µM -0.30031360366292 0.370936877878315 no 2149 0.381968978823177 3056 17087968
SGTC_2760 etidronate 98.04 µM -0.300392379505834 0.370904078944029 no 2150 0.381938937859846 2960 3305 A chelator and antioxidant.
SGTC_53 0973-0023 39.979 µM -0.300617356205665 0.370810413312025 no 2151 0.381853147493691 2937 674768
SGTC_1644 st010134 20.9 µM -0.301136265589742 0.370594402470294 no 2152 0.38165529390627 3024 3818134
SGTC_3020 9089140 49.47 µM -0.301366492558475 0.370498576982403 no 2153 0.381567521171806 3025 17217859
SGTC_89 0302-0250 142.109 µM -0.301867579454031 0.370290041463695 no 2154 0.381376505673188 2920 4203518 YLR208W SEC13
SGTC_2273 7815444 169.05 µM -0.302154549025457 0.370170631538018 no 2155 0.381267125208155 3124 2824616
SGTC_706 4262-0057 46.9 µM -0.303174654062485 0.369746260488753 no 2156 0.380878381851115 2954 883298
SGTC_1427 4048-4900 550 nM -0.304810425471939 0.369066099018904 no 2157 0.380255270388418 3064 24132586
SGTC_2373 9071805 200 µM -0.305223138226969 0.368894555760327 no 2158 0.380098105470861 3090 10149009
SGTC_2249 haloperidol 116.36 µM -0.306426760196892 0.368394421861586 no 2159 0.379639867992978 2914 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_759 3486-0358 89.3 µM -0.309013182179542 0.367320456357232 no 2160 0.378655749657138 3132 875103
SGTC_1627 st003713 25.6 µM -0.310081125640509 0.366877313947901 no 2161 0.378249632459317 3030 16195070 YER133W GLC7
SGTC_595 3909-8003 73.7 µM -0.310813840089689 0.366573377124114 no 2162 0.377971073793008 3080 699517
SGTC_2444 5485484 36.41 µM -0.312218288511382 0.365991032731495 no 2163 0.37743731705643 3083 6790631
SGTC_1446 4239-0190 62 µM -0.312724566355613 0.365781183879522 no 2164 0.377244964892608 2979 1340085
SGTC_1681 tripelennamine 100 µM -0.313119051127464 0.365617700354358 no 2165 0.377095107823058 2986 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1159 4092-0538 61.2 µM -0.313246929292713 0.365564709950418 no 2166 0.377046533374144 2972 717301
SGTC_2640 pentamidine 10.38 µM -0.313658316019585 0.365394256122175 no 2167 0.376890281559778 3057 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1085 doxorubicin 7.67 µM -0.314014038271863 0.365246887721872 no 2168 0.3767551883308 3057 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_353 1988-1175 58.3 µM -0.314673611923729 0.364973692607258 no 2169 0.376504740891705 2874 2788357
SGTC_107 0358-0022 2.6945 µM -0.315994874365656 0.364426632549876 no 2170 0.376003199312942 3038 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_181 1447-1644 8.07 µM -0.316453439328912 0.364236831199988 no 2171 0.37582918029907 3060 534600
SGTC_3130 9127414 49.47 µM -0.316653666677263 0.364153966966445 no 2172 0.37575320472825 2997 1494646
SGTC_911 3456-4043 236 µM -0.318297883843935 0.363473747003815 no 2173 0.375129494679463 3053 914281
SGTC_1946 st076057 65.1 µM -0.318484234027633 0.363396680207142 no 2174 0.375058825987603 2938 953009
SGTC_848 0368-0089 85.6 µM -0.318617350608956 0.363341632031181 no 2175 0.375008347388917 3084 762535
SGTC_3071 9117417 49.47 µM -0.319234173102468 0.363086592071973 no 2176 0.374774472590789 3017 45595590 YGL055W OLE1
SGTC_2519 cryptotanshinone 88.04 µM -0.319539370099532 0.36296042354057 no 2177 0.374658770932299 3128 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_70 0141-0289 43.283 µM -0.32041997567435 0.36259646433798 no 2178 0.374324992376578 3040 352408
SGTC_2290 7904846 200 µM -0.320944852840699 0.362379588691984 no 2179 0.374126091395683 3021 2962154
SGTC_45 0kpi-0036 14.9 µM -0.324085077349963 0.361082994058625 no 2180 0.372936812153923 3118 2795021
SGTC_207 4185-0010 4.486 µM -0.325084673762417 0.360670595845445 no 2181 0.372558494056692 3058 3761753
SGTC_1283 0922-0125 16.4 µM -0.325329696622767 0.360569532758531 no 2182 0.372465778792466 3067 3360884
SGTC_390 dec-rvkr-cmk 16.7 µM -0.325815409576074 0.360369222487469 no 2183 0.372282009608956 3036 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1026 k007-1105 30.6 µM -0.3263228614196 0.360159987927167 no 2184 0.372090046592 2970 7066794
SGTC_1954 st077032 68.9 µM -0.326615266261949 0.36003944141682 no 2185 0.371979447738016 3058 698907
SGTC_2086 5274770 176.623 µM -0.327807818278245 0.359547945427154 no 2186 0.371528487776456 3057 689278
SGTC_13 0199-0087 65 µM -0.331320869490124 0.358101436028216 no 2187 0.370201064560951 2990 4589825
SGTC_2731 amoxapine 43.43 µM -0.331428649594685 0.358057089310241 no 2188 0.370160363672016 3050 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2895 9054447 58.44 µM -0.333018263696732 0.357403256534777 no 2189 0.369560248420158 3005 2697450
SGTC_1194 1488-0194 225 µM -0.333037262795443 0.357395444439067 no 2190 0.369553077748955 2957 1391452
SGTC_1460 k062-0059 9.15 µM -0.333272242622297 0.357298829802462 no 2191 0.369464395026201 2886 1373085
SGTC_2160 5660466 132.927 µM -0.334663735884139 0.35672688912684 no 2192 0.368939380030839 3069 2859134
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.336275781968432 0.356064697972305 no 2193 0.368331455405953 2973 91467 include heat shock
SGTC_3206 9114350 49.47 µM -0.337015741512159 0.355760884925584 no 2194 0.368052516780775 3105 17087243
SGTC_3192 9110362 49.47 µM -0.338039387814164 0.355340746624137 no 2195 0.367666752952876 2984 16649480
SGTC_1338 1486-1223 76 µM -0.338641327245012 0.355093772797658 no 2196 0.367439972772097 3068 3444526
SGTC_3089 9117425 49.47 µM -0.33931127122027 0.354818968493015 no 2197 0.367187626289426 3061 9401657
SGTC_156 3474-0145 5.642 µM -0.339800964952044 0.354618148799995 no 2198 0.367003210591402 3063 2265471
SGTC_377 3970-0964 33.1 µM -0.340799213509851 0.354208899795278 no 2199 0.366627371292333 2994 16481235
SGTC_2110 5483698 200 µM -0.342049504057855 0.353696559349896 no 2200 0.366156818877815 3048 2848765 YHR062C RPP1
SGTC_862 0452-0056 10.2 µM -0.342434632257195 0.353538795950188 no 2201 0.366011914667023 3081 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2447 5741742 33.78 µM -0.342832588678547 0.353375804041543 no 2202 0.365862203921286 3102 1776504
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.343988190027829 0.352902654281491 no 2203 0.365427583869106 3077 368090
SGTC_2242 6630449 61.2675 µM -0.345230331169088 0.352394325210611 no 2204 0.364960608956807 3150 691249 YDR170C SEC7
SGTC_175 3793-3120 23.7 µM -0.346121512756771 0.352029783784663 no 2205 0.364625698325183 3007 5322297
SGTC_354 2783-3500 4.88 µM -0.346638553328081 0.351818348547653 no 2206 0.36443143914665 3032 6740761
SGTC_805 3852-0218 479 µM -0.346981134073113 0.351678281019585 no 2207 0.364302746071054 2993 6615355
SGTC_3137 9097352 49.47 µM -0.347814451843752 0.351337654879253 no 2208 0.36398976776611 3311 44120435
SGTC_2894 9048625 32.47 µM -0.348555952679737 0.351034660089571 no 2209 0.363711350410206 3194 4092861
SGTC_572 0960-0087 17.7 µM -0.349031900254874 0.350840226526606 no 2210 0.363532680403079 3046 6796365
SGTC_603 3794-0023 45.9 µM -0.349320586214036 0.350722311891611 no 2211 0.36342432258403 3120 3802260
SGTC_1556 plumbagin 1.48 µM -0.351279184365927 0.349922696883219 no 2212 0.362689454805809 3061 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_902 1120-0002 2.07 µM -0.352314729736644 0.349500194878199 no 2213 0.362301121357541 3017 3280475
SGTC_1058 3448-5425 97.3 µM -0.352690003433241 0.349347129374889 no 2214 0.362160427244917 3026 7279705
SGTC_2177 5811945 192 µM -0.35294162113884 0.34924451402182 no 2215 0.362066103509401 3166 5343475
SGTC_369 0957-0393 4.5 µM -0.354197862859967 0.348732355408878 no 2216 0.36159530255166 3069 6997992
SGTC_1978 st071761 42 µM -0.354198057808389 0.348732275951494 no 2217 0.361595229507193 3034 5147680
SGTC_1466 k213-0079 57.5 µM -0.355014851026944 0.348399424377787 no 2218 0.361289232739716 3032 3657981
SGTC_2229 7354935 190 µM -0.355416063420051 0.348235968959263 no 2219 0.361138958273613 3099 318112
SGTC_578 3460-0051 92 µM -0.356326637833838 0.347865102177667 no 2220 0.36079798133311 3156 2876744
SGTC_3129 9127257 49.47 µM -0.357134746864007 0.347536090248809 no 2221 0.360495466582883 3033 837894
SGTC_300 r073-0011 5.04 µM -0.358548456014892 0.346960791719637 no 2222 0.359966456114229 3149 2735780
SGTC_1142 3253-1408 9.78 µM -0.359254915958295 0.346673435084059 no 2223 0.359702198948436 3157 256655
SGTC_2057 5236571 38.335 µM -0.359446212624541 0.346595639234193 no 2224 0.359630654386395 3214 54684039 YBR257W POP4
SGTC_1724 st037281 8.293 µM -0.360471714113787 0.346178702291935 no 2225 0.359247202853928 3006 574124 YDL195W SEC31
SGTC_3073 9114972 49.47 µM -0.361234299243634 0.345868779737754 no 2226 0.358962151843715 3147 41905075
SGTC_141 0443-0274 32.331 µM -0.361743454653323 0.34566191112916 no 2227 0.358771875463707 3187 1627241
SGTC_871 0574-0004 149 µM -0.363579139612343 0.34491645969463 no 2228 0.358086153186422 3028 9551173
SGTC_2011 4012611 177 µM -0.364420102904695 0.344575154507335 no 2229 0.357772163044428 3022 2049887
SGTC_2778 tioconazole 65.09 nM -0.365189401804027 0.344263045101536 no 2230 0.357485014467493 3044 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_103 0844-0104 51.839 µM -0.365991353209993 0.343937801249336 no 2231 0.357185763883343 3165 5375804
SGTC_33 0986-0033 35.816 µM -0.36655107758419 0.343710864722245 no 2232 0.356976953073174 3099 2848082
SGTC_2479 5617353 43.85 µM -0.367659696679035 0.343261548754395 no 2233 0.356563498065101 3214 2731746
SGTC_1779 st039427 55 µM -0.368286867653697 0.343007458557334 no 2234 0.356329671778491 3263 1124498
SGTC_3276 9139060 49.47 µM -0.368927355477479 0.342748046463381 no 2235 0.356090936346098 3013 4870619
SGTC_2079 5212404 121 µM -0.369044984829231 0.342700411962331 no 2236 0.356047097309655 3192 758462
SGTC_3294 9122953 26.2835 µM -0.369124897894665 0.34266805225681 no 2237 0.356017315762422 3044 16459826
SGTC_3134 9127454 49.47 µM -0.369556115441306 0.342493456523285 no 2238 0.355856627220924 3174 24262820
SGTC_2804 7954240 19.48 µM -0.373245417460697 0.341001073364359 no 2239 0.354482898140191 3186 828705
SGTC_3180 9109287 49.47 µM -0.37391577494789 0.340730168807993 no 2240 0.35423348983015 3175 18891271
SGTC_954 1189-0853 2.85 µM -0.374798436871648 0.340373593154163 no 2241 0.353905188435532 3077 2828194
SGTC_2852 9023854 51.95 µM -0.375378183560773 0.340139466076046 no 2242 0.35368961381862 3222 19798528
SGTC_205 1486-1330 71.903 µM -0.376222433475324 0.339798631251934 no 2243 0.353375769499681 3082 4118834
SGTC_2694 st077685 81.9 µM -0.376284939451383 0.339773401967509 no 2244 0.353352537277144 3013 2838096
SGTC_3210 9128157 49.47 µM -0.376687843667224 0.339610794984829 no 2245 0.353202798945455 3132 17590849
SGTC_1805 st050013 60.3 µM -0.377936948095323 0.339106862264323 no 2246 0.35273871697133 3096 4037144
SGTC_734 2023-0417 80 µM -0.378556618288809 0.338856972192533 no 2247 0.352508571054422 3154 3935732
SGTC_587 k089-0003 57 µM -0.378828131589638 0.338747503251508 no 2248 0.352407747839581 3135 9659696
SGTC_942 3253-1115 227 µM -0.379747481714237 0.338376940140032 no 2249 0.352066435213048 3265 46497897
SGTC_2712 st079126 47.7 µM -0.381187555774135 0.337796803063654 no 2250 0.351532041184404 3054 3152970
SGTC_2585 alliin 100 µM -0.382663864237885 0.337202468639761 no 2251 0.35098450544618 3272 87310 A garlic compound which reacts with lipids.
SGTC_3022 9087993 49.47 µM -0.38389052020417 0.336708948460331 no 2252 0.350529796411765 3168 17173644
SGTC_3126 9127922 49.47 µM -0.383914233428909 0.336699410691416 no 2253 0.350521008265064 3281 45595682
SGTC_2906 7926292 26.41 µM -0.385393328542097 0.33610470712271 no 2254 0.349973012316781 3198 2966319
SGTC_551 k048-0028 34.9 µM -0.386206876282754 0.335777776564939 no 2255 0.349671730771408 3219 6836383
SGTC_1273 0849-0096 14.1 µM -0.386699079716873 0.335580041050807 no 2256 0.349489498767665 3133 5286025
SGTC_336 4111-0029 111 µM -0.388093249012419 0.335020201224386 no 2257 0.348973513851045 3103 3131175
SGTC_3320 9137005 35.139 µM -0.389176926788998 0.33458529472603 no 2258 0.348572635229043 3141 4908713
SGTC_432 NS 1619 61.3 µM -0.389329652942333 0.334524019794081 no 2259 0.348516151711293 3238 4552 A K+/calcium channel activator.
SGTC_1295 1013-0063 9.78 µM -0.390980198893515 0.333862089298888 no 2260 0.347905936116309 3225 6826038
SGTC_929 2805-0021 398 µM -0.391402237352307 0.333692918991431 no 2261 0.347749969401106 3168 3098024
SGTC_1183 1254-0324 198 µM -0.391734195428491 0.333559880341584 no 2262 0.34762731050344 3214 5799357
SGTC_1479 0549-0158 134 µM -0.393351105522046 0.332912171689803 no 2263 0.347030088585784 3132 5440202
SGTC_1442 4112-3290 3 µM -0.394999900760823 0.332252203378286 no 2264 0.346421480605827 3087 704353
SGTC_3147 9097027 49.47 µM -0.39576832445928 0.33194480154357 no 2265 0.346137973150717 3107 25236841
SGTC_1910 st062352 60.4 µM -0.396915777540821 0.331485982553574 no 2266 0.345714784541894 3021 2245730
SGTC_1039 k821-0043 94 µM -0.39699453872503 0.331454498478966 no 2267 0.345685743935906 3230 15992768
SGTC_2431 5490079 200 µM -0.397052310060883 0.331431405664514 no 2268 0.345664443226021 3155 5722345
SGTC_3355 9151058 44.0485 µM -0.397883588352857 0.331099191533616 no 2269 0.345357999025794 3196 17015728
SGTC_2728 chlorpromazine 9.18 µM -0.399384658148907 0.330499637099019 no 2270 0.34480489829627 3106 2726 A thorazine and dopamine antagonist.
SGTC_2707 st078556 66.6 µM -0.400540921479932 0.330038100927864 no 2271 0.344379074719404 3158 17250899
SGTC_2936 9038235 15.59 µM -0.400827781918381 0.329923637198014 no 2272 0.344273461525117 3071 4749415
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.401492559447006 0.329658437317689 no 2273 0.344028757565621 3140 688664
SGTC_819 1013-0258 27.7 µM -0.402723880295159 0.329167452418801 no 2274 0.343575682130045 3127 5753198
SGTC_2742 clothiapine 36.27 µM -0.402808838581215 0.329133586450186 no 2275 0.343544429251663 3168 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1468 k284-1086 134 µM -0.403552241217949 0.328837312036468 no 2276 0.343271005723471 3148 15996457
SGTC_1571 st070080 73.4 µM -0.403984605994271 0.328665047560341 no 2277 0.343112019649721 3269 4315245
SGTC_673 1082-0474 110 µM -0.404083828697417 0.328625519994584 no 2278 0.343075538105588 3142 3098046
SGTC_1451 4152-0210 104 µM -0.404317659678453 0.328532375818554 no 2279 0.342989570469987 3263 659563
SGTC_337 1315-0038 354 µM -0.404828253090843 0.328329023201055 no 2280 0.34280187976492 3137 1626437
SGTC_155 k072-0202 43.6 µM -0.405144291423821 0.328203180968355 no 2281 0.342685725632594 3205 5857737
SGTC_1816 st051957 91.6 µM -0.406430705267948 0.327691149493733 no 2282 0.342213081226043 3150 674121
SGTC_3270 9137563 49.47 µM -0.40714866998372 0.327405518640509 no 2283 0.341949399458687 3186 17015724
SGTC_1049 3226-0134 66 µM -0.407423013601191 0.32729640205573 no 2284 0.341848663584464 3196 5702385
SGTC_2439 5492030 7.2 µM -0.407740264740898 0.327170237963877 no 2285 0.341732186591753 3202 5722370
SGTC_1940 st075990 51.1 µM -0.410777265844551 0.325963487621319 no 2286 0.340617932363173 3368 1084979
SGTC_2902 5787006 60.46 µM -0.411154951440014 0.325813541540344 no 2287 0.340479459138661 3088 591003
SGTC_839 0122-0028 230 µM -0.411686306973843 0.325602634201263 no 2288 0.340284681354107 3127 759448
SGTC_1728 st035614 33.7865 µM -0.412471089579019 0.325291237891805 no 2289 0.339997083328128 3170 15945546
SGTC_2146 5545642 200 µM -0.413795724540386 0.324765908616366 no 2290 0.339511857697883 3217 825326
SGTC_2541 muurolladie-3-one 83.07 µM -0.414203370942601 0.324604312545784 no 2291 0.339362586647161 3296 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1665 st014639 11.4 µM -0.414416732184662 0.324519746672461 no 2292 0.339284468549274 3196 981133 YIL048W NEO1
SGTC_952 1185-0122 232 µM -0.415825742856526 0.323961511659956 no 2293 0.338768760059601 3115 678600
SGTC_2286 7945697 125 µM -0.415857965666708 0.323948749949118 no 2294 0.338756969798793 3182 1245733
SGTC_2759 disulfiram 3.38 µM -0.415898304585916 0.323932774178499 no 2295 0.338742210092868 3090 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_996 3970-0799 1.8 µM -0.415899063159759 0.323932473757054 no 2296 0.338741932538799 3174 6615648 YGL040C HEM2
SGTC_2979 9012552 45.46 µM -0.415985923641398 0.323898074764386 no 2297 0.338710151795183 3240 17100905
SGTC_310 1273-0058 1.06 µM -0.416692513534626 0.323618302829231 no 2298 0.338451665491541 3239 2734232
SGTC_1915 st067105 30.6 µM -0.417261507184495 0.323393084102301 no 2299 0.338243570260603 3203 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2789 5281112 71.43 µM -0.417303970405093 0.323376278928912 no 2300 0.338228042377336 3160 765948
SGTC_962 1254-0300 21.5 µM -0.418243049771169 0.32300472259622 no 2301 0.337884711691576 3108 7340576
SGTC_3138 9097216 49.47 µM -0.419102067114454 0.322664998220357 no 2302 0.337570770023651 3209 25237486
SGTC_244 nsc-207895 1.295 µM -0.419275283289009 0.322596512566458 no 2303 0.337507479078559 3106 42640
SGTC_1060 3448-7350 82 µM -0.419927189020631 0.322338818138657 no 2304 0.337269322387798 3250 570178
SGTC_306 1672-3436 11.6 µM -0.42002245444943 0.32230116743073 no 2305 0.337234525114714 3233 6797378
SGTC_1116 jasmonic acid 1.58368 µM -0.420056438136362 0.322287736872935 no 2306 0.337222112348059 3274 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1623 st003709 20.3 µM -0.421571486525023 0.321689216558665 no 2307 0.336668911103359 3131 16192618
SGTC_278 4092-0821 23.9 µM -0.422287173564994 0.321406644910025 no 2308 0.336407709575735 3222 877900
SGTC_2221 6807166 181.081 µM -0.42270411758149 0.32124207231136 no 2309 0.336255575511241 3195 674925
SGTC_1815 st051655 58.2 µM -0.423080155245794 0.321093676018471 no 2310 0.336118390303822 3239 5984156
SGTC_60 0986-0278 202 µM -0.423326394425277 0.320996517767527 no 2311 0.336028569708399 3113 3110598
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.424344600541593 0.320594895761967 no 2312 0.335657258400601 3183 165521
SGTC_2026 5148700 152 µM -0.425930483513797 0.319969777129896 no 2313 0.335079250794704 3124 79838
SGTC_1610 st001799 48.1 µM -0.42613785890703 0.319888072243869 no 2314 0.335003697405165 3076 621897
SGTC_3095 9117207 49.47 µM -0.426418347092949 0.319777575177789 no 2315 0.334901517344286 3219 17015229
SGTC_2183 6420625 130.508 µM -0.427379976058899 0.319398867196316 no 2316 0.334551294841691 3234 2897619
SGTC_1635 st007035 42.4 µM -0.431753840827239 0.317678736053609 no 2317 0.332960165635124 3243 3716403
SGTC_2149 5554786 194.827 µM -0.434455017874408 0.316618390257078 no 2318 0.331979026384777 3175 745063 YPR165W RHO1
SGTC_1261 0712-0010 12.7 µM -0.434485933704775 0.316606262958647 no 2319 0.331967803583558 3332 2840123
SGTC_1737 st035557 69.7 µM -0.434862578627168 0.316458532951149 no 2320 0.331831089262526 3189 5716916
SGTC_3174 9107204 49.47 µM -0.435092015148947 0.316368556284726 no 2321 0.331747819520825 3276 3938802
SGTC_2135 5326629 150.42 µM -0.435780496502336 0.316098624178764 no 2322 0.331497997856854 3175 5020077
SGTC_1668 st014914 51.6 µM -0.436705430556545 0.315736140605325 no 2323 0.331162495185548 3261 2839556
SGTC_1224 0823-0416 294 µM -0.43756692408569 0.315398678840673 no 2324 0.330850126252232 3297 3598164
SGTC_2178 5812956 200 µM -0.437792186871903 0.315310464925981 no 2325 0.330768467628847 3160 5403383
SGTC_3041 9091929 49.47 µM -0.437850320222779 0.315287701354585 no 2326 0.330747395373427 3348 25236887
SGTC_3293 9120939 62.045 µM -0.442298313303762 0.313548062857486 no 2327 0.329136675667606 3292 934087
SGTC_3284 9108171 64.8615 µM -0.442903708116646 0.313311608232584 no 2328 0.328917692589996 3226 8687505
SGTC_331 k048-0133 24.5 µM -0.445015868328946 0.312487243660458 no 2329 0.328154143307415 3174 6813582
SGTC_126 0417-1624 672.48 µM -0.446274672984675 0.311996384623805 no 2330 0.327699424408257 3326 41912 YDL195W SEC31
SGTC_2651 TUB2.036 5 µM -0.447641019784751 0.31146396816011 no 2331 0.327206147037386 3351 15992207 YFL037W TUB2
SGTC_2518 prenyletin 46.28 µM -0.447703219622712 0.311439740477479 no 2332 0.327183698876332 3262 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1698 5-fluorocytosine 1.055 µM -0.448765775703834 0.31102598662659 no 2333 0.326800314902967 3310 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_552 k242-0005 476 µM -0.453043059997043 0.309362853203309 no 2334 0.325258867634629 3309 4088318
SGTC_2866 9034245 58.44 µM -0.453706011831563 0.309105426149278 no 2335 0.325020219659888 3226 6462273
SGTC_2296 7971656 126.45 µM -0.454260462433232 0.308890202539995 no 2336 0.32482068483471 3265 666570
SGTC_3349 9149703 23.001 µM -0.454973627661672 0.308613466417147 no 2337 0.324564105926495 3243 4910494
SGTC_2347 9049783 174.81 µM -0.455892308868157 0.308257142182821 no 2338 0.324233710230451 3322 6467988 YPL169C MEX67
SGTC_1302 1159-0335 255 µM -0.456352500850437 0.30807871771531 no 2339 0.32406825818605 3207 649284
SGTC_914 3820-6779 408 µM -0.456798015903192 0.307906026951089 no 2340 0.323908116011476 3162 2893481
SGTC_1309 pyrazolanthrone 13.4 µM -0.459271225985847 0.30694813433314 no 2341 0.323019703990607 3305 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1743 st037606 46.3785 µM -0.459963968138944 0.306680065868667 no 2342 0.322771041842614 3199 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1440 4100-1550 40 µM -0.460340270989177 0.306534492341542 no 2343 0.322635999855261 3249 742806
SGTC_2218 6965428 192.983 µM -0.460501705291223 0.306472050505645 no 2344 0.322578073875516 3292 675684
SGTC_2200 6600604 21.907 µM -0.461918300245747 0.305924361061123 no 2345 0.32206995500399 3214 2904777
SGTC_554 4483-2211 187 µM -0.463079603792355 0.30547569677288 no 2346 0.321653654575884 3267 747107
SGTC_2922 7999257 32.47 µM -0.463943642552101 0.305142068761337 no 2347 0.321344061877137 3300 2988377
SGTC_836 0330-0104 1.35 µM -0.464881502593172 0.304780119602033 no 2348 0.321008158803444 3266 46494820
SGTC_1855 st056195 39.6 µM -0.465243243726767 0.304640563543243 no 2349 0.320878637054505 3347 4028379
SGTC_2863 9028737 58.44 µM -0.465908142746927 0.304384126403968 no 2350 0.320640626202559 3255 6460917
SGTC_2986 9022445 71.43 µM -0.466910844194384 0.303997588036735 no 2351 0.320281833206224 3331 6459286
SGTC_246 cycloheximide 667 µM -0.4679522312993 0.303596368297827 no 2352 0.319909375247694 3187 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2105 5350118 200 µM -0.46903300665118 0.30318022347933 no 2353 0.319523021751846 3263 2133313
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.469319637198774 0.303069901247221 no 2354 0.319420590449847 3202 15053
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.473396757165914 0.30150259313484 no 2355 0.317965071502633 3337 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_121 0557-0495 61.343 µM -0.473863021062916 0.301323586692159 no 2356 0.317798795246241 3274 3104427
SGTC_1223 0764-0573 147 µM -0.475878257453853 0.300550455027482 no 2357 0.317080556480326 3272 1609797
SGTC_1791 st048313 56.1 µM -0.477785988528473 0.29981939350695 no 2358 0.316401267381282 3312 1204976
SGTC_2687 chenodiol 100 µM -0.480014405992619 0.298966462814996 no 2359 0.31560857473495 3340 5702181 A cholesterol synthesis inhibitor.
SGTC_2366 9070441 60.58 µM -0.481368900760272 0.298448566666969 no 2360 0.315127167779423 3243 6837235
SGTC_582 0987-0078 156 µM -0.481497326993336 0.298399483610866 no 2361 0.315081539521201 3383 1625765
SGTC_1622 st003707 19.4 µM -0.484630031248491 0.297203339021821 no 2362 0.313969403504994 3344 10140899
SGTC_149 3970-0822 46.1 µM -0.484978351109532 0.297070477311814 no 2363 0.313845851135634 3386 3114250 YBL034C STU1
SGTC_1865 st057639 52.2 µM -0.485470454168536 0.29688281783172 no 2364 0.313671333070275 3285 688818
SGTC_1867 st057372 64 µM -0.486380596610494 0.29653588547263 no 2365 0.313348672550158 3335 688837
SGTC_2676 harmalol 100 µM -0.487053917999714 0.296279345276253 no 2366 0.313110060891585 3355 5459187 A monoamine oxidase inhibitor
SGTC_1386 3228-0095 33.8 µM -0.488673152833379 0.295662822477657 no 2367 0.31253655686323 3358 870181
SGTC_1497 4476-2978 41.3 µM -0.489904174992943 0.295194506355357 no 2368 0.312100854286221 3344 1528379
SGTC_3239 9133757 49.47 µM -0.491718358748297 0.294504962043371 no 2369 0.311459229019339 3329 17036923
SGTC_1493 4348-0038 111 µM -0.49251544692649 0.294202235891382 no 2370 0.311177502380774 3364 800424
SGTC_1990 st072050 59.8 µM -0.49323646163937 0.293928525585697 no 2371 0.310922758757487 3249 17233948
SGTC_3008 9078912 71.4286 µM -0.494037570458501 0.293624548283333 no 2372 0.310639823107467 3282 16648731
SGTC_1425 4048-4433 7.33 µM -0.494349389516102 0.293506269241465 no 2373 0.310529725100461 3382 23734946
SGTC_2361 9034121 116 µM -0.494632015653513 0.293399082710993 no 2374 0.31042994927822 3275 6496917
SGTC_2111 5486399 200 µM -0.494697414018003 0.293374282833894 no 2375 0.310406863607106 3311 689674
SGTC_435 c-PAF 6.7 µM -0.495315682765339 0.293139875609673 no 2376 0.310188651197923 3340 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2406 ethylparaben 405.7 µM -0.495779433816798 0.29296410845447 no 2377 0.310025018274067 3113 8434 A possible steroid mimic.
SGTC_1926 methyl fluorone black 53.6 µM -0.495817260378394 0.29294977389583 no 2378 0.310011672964099 3256 72721 Reacts with homocysteine.
SGTC_119 0121-0043 24.815 µM -0.497574344888078 0.292284277210328 no 2379 0.309392045027529 3395 1092378
SGTC_2786 7743617 45.45 µM -0.497905976722942 0.292158750404835 no 2380 0.309275157256559 3264 583674
SGTC_1201 1889-3372 45.9 µM -0.497979903397796 0.292130771651652 no 2381 0.309249103509407 3247 5392199
SGTC_609 0986-0026 86.3 µM -0.498541060850066 0.291918433148918 no 2382 0.30905136782085 3304 2848610
SGTC_1126 isoteolin 1.0172 µM -0.501252798074567 0.290893342944016 no 2383 0.308096610190875 3293 133323
SGTC_2878 9043973 25.97 µM -0.501423646533822 0.290828815230767 no 2384 0.308036500659571 3401 6465167
SGTC_3000 9075062 71.4286 µM -0.50286608198263 0.290284289060732 no 2385 0.307529214674608 3265 17057871
SGTC_2288 7946289 167.31 µM -0.503328598285069 0.290109788140591 no 2386 0.307366631486409 3436 1246052
SGTC_1962 st076595 64.5 µM -0.503618953657607 0.290000266251149 no 2387 0.307264585440905 3297 279619
SGTC_2365 9042475 200 µM -0.504127379047999 0.28980853517229 no 2388 0.307085934142072 3381 6464479
SGTC_631 k072-0230 41.5 µM -0.504422075721818 0.289697430048136 no 2389 0.306982404127475 3356 5773147
SGTC_1874 staurosporine 7.6 µM -0.505237321089995 0.289390174345374 no 2390 0.306696080118772 3382 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2236 dapsone 200 µM -0.506388048108293 0.288956740593247 no 2391 0.306292131616092 3364 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.506584676428085 0.288882708980433 no 2392 0.306223131202883 3391 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_991 3996-0057 64.7 µM -0.50690200877382 0.288763250488625 no 2393 0.30611178807338 3332 715343
SGTC_1306 1185-0270 9.02 µM -0.50768596623831 0.288468232583463 no 2394 0.305836795905369 3370 1548076
SGTC_2725 haloperidol 53.21 µM -0.50867121811287 0.28809766538955 no 2395 0.305491350016275 3305 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3229 9132204 49.47 µM -0.508874396246863 0.288021275161614 no 2396 0.305420133861722 3306 17682924
SGTC_2293 7624732 200 µM -0.508880765884718 0.288018880481279 no 2397 0.30541790135312 3332 894453
SGTC_253 dyclonine 31.25 µM -0.510558862545995 0.287388323722685 no 2398 0.304829993792409 3382 3180 An oral anasthetic.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.511765577669131 0.286935295937856 no 2399 0.304407542064423 3413 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_420 mitomycin C 81.9 mM -0.512380120216362 0.286704713050407 no 2400 0.304192500717854 3284 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.513362530509664 0.28633628486911 no 2401 0.303848875364768 3352 6312947
SGTC_1616 st002734 56.1 µM -0.513601173238296 0.286246821879144 no 2402 0.303765429571954 3266 4026101
SGTC_127 0180-0333 59.125 µM -0.513651523372928 0.286227948189085 no 2403 0.303747825033299 3398 771601
SGTC_3305 9127027 53.8275 µM -0.515684817700288 0.285466264415557 no 2404 0.303037280051692 3287 41905295
SGTC_2990 9074105 71.4286 µM -0.516205440748941 0.285271391319438 no 2405 0.302855465351948 3375 6502001
SGTC_1733 st037357 54.9 µM -0.517963353609044 0.284613860124291 no 2406 0.302241919042734 3251 1272339 YGL099W LSG1
SGTC_567 1080-0542 68.4 µM -0.518150691084028 0.284543830948895 no 2407 0.302176567464127 3385 5950415
SGTC_317 4495-0002 170 µM -0.518276528389936 0.284496795954339 no 2408 0.302132673419934 3355 15991618
SGTC_2033 5192550 145 µM -0.518915934777946 0.284257858436932 no 2409 0.301909682588528 3309 182073
SGTC_2625 euphol 100 µM -0.519329144483656 0.284103498606147 no 2410 0.30176561643665 3421 6708538 A triterpene alcohol.
SGTC_1252 0493-0875 34.8 µM -0.519660388283148 0.283979787158094 no 2411 0.301650150136255 3309 3960963
SGTC_2161 5662504 8.5105 µM -0.520657487337594 0.283607550731522 no 2412 0.301302697313541 3328 2859334
SGTC_3285 9112818 20.8695 µM -0.520772992087693 0.283564445678958 no 2413 0.30126245975138 3387 17017947 YPR165W RHO1
SGTC_1326 1431-2094 10.8 µM -0.522697860314972 0.282846569306664 no 2414 0.300592263743966 3280 616278
SGTC_2799 7812892 81.82 µM -0.522919177153378 0.282764085546728 no 2415 0.300515249343421 3434 20205235
SGTC_2080 5212524 12.4 µM -0.523024363335458 0.282724887195914 no 2416 0.300478649510593 3407 260183
SGTC_1485 3909-9022 254 µM -0.523312968803685 0.282617349804113 no 2417 0.300378238754765 3405 714516
SGTC_2630 antimycin a 100 µM -0.525029281873788 0.28197824018535 no 2418 0.299781417657653 3326 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2072 5231554 129 µM -0.525649320900367 0.2817475253366 no 2419 0.299565940870706 3453 789545
SGTC_3326 9140064 16.379 µM -0.527261712725266 0.281147985035971 no 2420 0.29900592918884 3303 1868434
SGTC_1687 st020778 55.3625 µM -0.528961711504683 0.280516537663725 no 2421 0.298416005491626 3389 4259299
SGTC_3268 9137683 49.47 µM -0.529016743930942 0.280496107899969 no 2422 0.298396917312585 3314 1953228
SGTC_1063 disulfiram 1.84 µM -0.530736121816668 0.279858183867661 no 2423 0.297800825519065 3378 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_458 nppb 133 µM -0.531314295661899 0.279643827865182 no 2424 0.297600500295359 3493 4549 A chloride channel blocker.
SGTC_800 3448-7362 155 µM -0.532274306084829 0.279288083347411 no 2425 0.297268012553889 3453 15991913
SGTC_2219 9098279 200 µM -0.533507956532491 0.278831261023359 no 2426 0.296841002380113 3410 902349
SGTC_2212 7123476 200 µM -0.534166288393198 0.278587628790646 no 2427 0.296613245312273 3376 1085715
SGTC_1275 0867-0008 21.1 µM -0.534497347284373 0.278465151326323 no 2428 0.296498742143639 3298 3422836
SGTC_2104 5389443 200 µM -0.534986836555994 0.278284109561733 no 2429 0.296329479865773 3479 2244536
SGTC_718 1130-0073 349 µM -0.535293970048172 0.278170542936057 no 2430 0.296223297683515 3501 6740020
SGTC_1605 st000082 49.1 µM -0.535759174552116 0.2779985705428 no 2431 0.296062500441029 3426 1114022
SGTC_2070 5230947 200 µM -0.535779329309565 0.277991121095679 no 2432 0.29605553488467 3461 2835538
SGTC_807 1315-0151 48 µM -0.537430180373046 0.277381277137631 no 2433 0.295485250427253 3507 4011080
SGTC_1574 spiramycin 23.7 µM -0.538671028799203 0.276923324027653 no 2434 0.295056933744935 3383 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1925 st057770 10.1 µM -0.53923055643796 0.276716943410431 no 2435 0.294863889308177 3319 5989122
SGTC_1304 1165-0502 251 µM -0.53928244675453 0.27669780759323 no 2436 0.294845989412699 3337 767425
SGTC_286 k060-0067 22.9 µM -0.540038717642078 0.276418987910727 no 2437 0.294585165815302 3360 5985051
SGTC_1382 3002-2117 298 µM -0.540750604012131 0.276156657739598 no 2438 0.294339746911192 3484 1497314
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.541442129594614 0.275901947583121 no 2439 0.294101437718455 3356 4330530
SGTC_1958 st076513 41.9 µM -0.542445048811744 0.275532746747726 no 2440 0.293755976546839 3330 732122 YGL099W LSG1
SGTC_2259 7964009 200 µM -0.54316075708229 0.275269424439847 no 2441 0.293509561672474 3458 313134
SGTC_1249 0481-0015 10.2 µM -0.545188891833006 0.274523909696664 no 2442 0.292811805279948 3332 4227577
SGTC_250 brefeldin a 552.239 µM -0.545430165075772 0.274435287284582 no 2443 0.292728849283592 3363 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2176 5809774 33.9695 µM -0.545441251513328 0.274431215449032 no 2444 0.292725037741216 3406 2870539
SGTC_1834 st055981 52.8 µM -0.545527229266464 0.274399638484192 no 2445 0.292695479177189 3488 471719 YDL150W RPC53
SGTC_1076 itraconazole 331 nM -0.546251259331599 0.274133795836472 no 2446 0.292446617597782 3435 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2342 7990637 118.86 µM -0.546947941885934 0.273878114565721 no 2447 0.292207248727551 3448 2033102 YER133W GLC7
SGTC_1821 st053465 65.6 µM -0.54717370098578 0.273795286673779 no 2448 0.292129701107882 3395 675086
SGTC_2391 6285546 200 µM -0.548285999064591 0.273387380848451 no 2449 0.291747769738263 3337 846083
SGTC_992 3909-8734 162 µM -0.549303840899889 0.27301437820379 no 2450 0.291398475966339 3378 4288319
SGTC_344 k064-0035 6.43 µM -0.549368737405857 0.272990604512887 no 2451 0.291376211987528 3327 5088750
SGTC_1752 st044819 83.042 µM -0.549527481007743 0.272932455919018 no 2452 0.291321755325805 3345 441209 YML126C ERG13
SGTC_1993 st073995 70.8 µM -0.549558686512177 0.272921025905414 no 2453 0.291311050901208 3384 3098394
SGTC_3228 9131799 49.47 µM -0.550830735597104 0.272455299415505 no 2454 0.290874856228087 3393 17015818
SGTC_1092 toremifene 6.32 µM -0.550843086312908 0.272450779469127 no 2455 0.290870622576683 3435 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1604 st002052 72.4 µM -0.552142698670771 0.271975373304574 no 2456 0.290425294827846 3489 6254834 YHR062C RPP1
SGTC_721 1187-1332 279 µM -0.55215376599382 0.27197132658237 no 2457 0.290421503847968 3365 25730
SGTC_1902 st060212 70.5 µM -0.553224155519251 0.271580084521582 no 2458 0.290054964164018 3490 688944
SGTC_745 0469-0705 296 µM -0.553711290508476 0.27140212284306 no 2459 0.289888223537628 3554 3486736
SGTC_1645 Cervolide 78 µM -0.556302846421195 0.270456345408934 no 2460 0.289001920817381 3420 23173 A fragrance.
SGTC_2582 agaric acid 100 µM -0.556494947224029 0.270386304649401 no 2461 0.288936273820943 3434 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2325 6158266 200 µM -0.556506216072682 0.27038219626138 no 2462 0.288932423112354 3412 3623240
SGTC_1221 2958-7315 257 µM -0.556622915234909 0.270339652006906 no 2463 0.288892546947674 3450 4562705
SGTC_2858 9025781 8.96 µM -0.556890843698889 0.27024198773241 no 2464 0.288801005452126 3495 4894980 YPL153C RAD53
SGTC_433 pimozide 108 µM -0.558029168967376 0.269827246504006 no 2465 0.28841223308464 3296 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3023 9089636 49.47 µM -0.55901198754468 0.269469419639901 no 2466 0.288076769515473 3527 17249241
SGTC_3179 9107801 49.47 µM -0.559416552871449 0.269322193694222 no 2467 0.28793873353412 3418 4818259
SGTC_3283 9109332 35.8195 µM -0.559448050857672 0.269310732909777 no 2468 0.287927987864677 3350 17027281
SGTC_1916 st067606 49.2 µM -0.560241379465306 0.269022154875575 no 2469 0.287657402963269 3410 19590279
SGTC_2726 cimetidine 79.27 µM -0.560265382070027 0.269013426203862 no 2470 0.28764921813773 3420 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_645 0845-0943 5.41 µM -0.560758664892911 0.268834072832562 no 2471 0.287481034362382 3399 1885106
SGTC_1277 0873-0036 22 µM -0.561638259779272 0.268514408817314 no 2472 0.287181253714733 3465 5965735
SGTC_270 tamoxifen 5.46 µM -0.562348796782958 0.268256323728093 no 2473 0.28693919892198 3560 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.562805799932726 0.268090394548211 no 2474 0.286783565227209 3399 5106787 A p450 inhibitor.
SGTC_1197 1601-0112 267 µM -0.563940893642663 0.267678487178414 no 2475 0.286397179116415 3394 7350313
SGTC_2118 5526350 200 µM -0.564253453190934 0.267565120345587 no 2476 0.286290827189619 3431 743594
SGTC_2154 5570129 200 µM -0.564351460575832 0.267529577587329 no 2477 0.286257482928837 3488 673366
SGTC_655 k060-0012 42 µM -0.565352739738605 0.267166596267498 no 2478 0.285916931513012 3390 5994525
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.565704401224936 0.267039171802016 no 2479 0.285797371408973 3505 1273210
SGTC_1713 st033146 12.748 µM -0.569629206565494 0.265619105225058 no 2480 0.284464607401448 3503 674619
SGTC_1522 st012842 45.6 µM -0.571304163179205 0.265014243274183 no 2481 0.283896740075517 3418 3491067 YOR116C RPO31
SGTC_2864 9034755 47.6 µM -0.572522759056864 0.264574622949186 no 2482 0.283483935839158 3483 4930451
SGTC_1227 3909-8010 46.6 µM -0.574130893367758 0.263995041240455 no 2483 0.282939614623498 3420 15982272
SGTC_114 0364-0001 490.298 µM -0.574383170946922 0.263904177565445 no 2484 0.282854269280733 3471 4003655
SGTC_558 k064-0027 21.3 µM -0.574949090674889 0.263700406338722 no 2485 0.282662863989855 3457 5088526
SGTC_3341 9147222 25.867 µM -0.575984535569824 0.263327780627832 no 2486 0.282312817184919 3482 1939759
SGTC_3166 9102297 49.47 µM -0.576859536739198 0.26301310356617 no 2487 0.28201717334498 3435 25237072
SGTC_3049 9092223 49.47 µM -0.577578238655787 0.262754780319186 no 2488 0.281774451207602 3463 8623917
SGTC_641 4092-0595 30 µM -0.577889575334685 0.262642916782842 no 2489 0.281669336929007 3499 786260
SGTC_2949 9072542 2.23 µM -0.578823230741782 0.262307599766786 no 2490 0.281354227237518 3485 16457352
SGTC_2132 5317594 122.667 µM -0.578985979710546 0.262249171852639 no 2491 0.281299316707165 3429 794577
SGTC_948 3448-0295 75.3 µM -0.579341567723799 0.262121536696788 no 2492 0.281179361437625 3496 678569
SGTC_415 dibenzyl ketone 100 µM -0.579877703857792 0.261929155599768 no 2493 0.28099854616732 3449 7593
SGTC_450 aminopyrene 156 nM -0.580304809930798 0.261775949459603 no 2494 0.280854542189131 3476 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1371 2421-0008 32.7 µM -0.580403745172288 0.261740467207969 no 2495 0.280821190065997 3423 2827552
SGTC_1377 2944-0135 198 µM -0.581354644339021 0.261399561482131 no 2496 0.280500729525363 3482 1894137
SGTC_3011 9081274 71.4286 µM -0.582904794461896 0.260844308288042 no 2497 0.279978696447104 3435 6625322
SGTC_1370 2001-0092 44.6 µM -0.58509072081518 0.260062356671793 no 2498 0.279243358913542 3596 790957
SGTC_1625 st003711 30.1 µM -0.585807217071019 0.259806314215257 no 2499 0.279002536635306 3568 24207034 YER133W GLC7
SGTC_1077 5-fluorocytosine 377 nM -0.585955842610173 0.259753218649678 no 2500 0.278952594608677 3482 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1547 harmine 94.2 µM -0.585964601174857 0.259750089880699 no 2501 0.278949651640021 3528 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3058 9093861 49.47 µM -0.586225409044211 0.259656931979049 no 2502 0.278862024410325 3534 17217477
SGTC_1168 k815-0004 80.5 µM -0.586823996497956 0.259443187901289 no 2503 0.278660959361964 3447 642433
SGTC_1783 st039459 87.517 µM -0.58828771204143 0.258920906295999 no 2504 0.278169596027856 3548 729761
SGTC_1513 0337-0559 19 µM -0.58913677028615 0.258618195579206 no 2505 0.277884764412148 3393 775073
SGTC_2138 5575593 77.673 µM -0.589296852898261 0.258561142621427 no 2506 0.277831077822224 3470 762213
SGTC_196 k015-0023 18.111 µM -0.589328208199896 0.258549968450357 no 2507 0.277820562849644 3476 5211998
SGTC_1879 gemcitabine 100 µM -0.591122993929163 0.257910773057178 no 2508 0.277219007126053 3485 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2619 obliquin 87.91 µM -0.591443905385503 0.257796570044198 no 2509 0.277111514886666 3502 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3059 1327-0034 3 µM -0.59184841544841 0.257652654129932 no 2510 0.27697604959108 3451 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_536 3852-0578 10.6 µM -0.592403087095985 0.257455381816828 no 2511 0.27679034980461 3545 2869208
SGTC_853 0419-0306 21 µM -0.596185486327666 0.256112243689442 no 2512 0.275525660153138 3425 762713
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.596657226991335 0.255944984245097 no 2513 0.275368127676688 3532 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_874 0599-0792 117 µM -0.598901256923603 0.255150126494065 no 2514 0.274619366612463 3562 765305
SGTC_50 0929-0078 56.389 µM -0.599678544551731 0.254875104806446 no 2515 0.274360244942979 3391 1377751
SGTC_3325 9138760 55.175 µM -0.600674936231902 0.25452278627237 no 2516 0.274028257942177 3444 43844959
SGTC_1218 1348-1416 30.7 µM -0.600681562917491 0.25452044396776 no 2517 0.274026050666444 3508 6787668
SGTC_3323 9138564 53.9225 µM -0.601670697967575 0.254170945561681 no 2518 0.27369667928098 3548 43912313 YNL103W MET4
SGTC_563 tetrahydrosecaminediol 614 µM -0.602324598260738 0.253940036398573 no 2519 0.273479045063043 3561 334274 A psychoactive constituent of the cannabis plant.
SGTC_3318 9139014 38.6185 µM -0.60238383305628 0.253919124494256 no 2520 0.273459334487961 3517 16643984
SGTC_803 4488-1585 147 µM -0.60314802401484 0.253649420067805 no 2521 0.273205110486804 3500 747204
SGTC_292 k038-0015 474 µM -0.603224950885232 0.253622278754929 no 2522 0.27317952565335 3510 46368540
SGTC_754 3474-0146 171 µM -0.603919936557319 0.253377143301546 no 2523 0.272948436672176 3409 24762078
SGTC_1417 3966-0327 90.4 µM -0.605322879899567 0.252882676608107 no 2524 0.272482240932982 3531 651118
SGTC_1340 1486-1359 257 µM -0.605592866658283 0.252787578217646 no 2525 0.272392570170985 3456 4309068
SGTC_2237 6667747 47.222 µM -0.605715901970673 0.252744247300761 no 2526 0.27235171128779 3379 729940 YDL015C TSC13
SGTC_2908 7930301 100 µM -0.606606821799519 0.252430597422377 no 2527 0.27205593597368 3447 2223178
SGTC_3269 9137823 49.47 µM -0.607676851359836 0.252054162967057 no 2528 0.271700909491157 3437 17682936
SGTC_2666 tannic acid 100 µM -0.607685264325235 0.252051204474987 no 2529 0.271698119056573 3550 16134267 A thiamine antagonist.
SGTC_2095 5432005 200 µM -0.608574743712913 0.251738514746569 no 2530 0.271403174696381 3502 783734
SGTC_1933 st074711 15.9 µM -0.609363858320156 0.251461279065741 no 2531 0.271141644117711 3525 17250958
SGTC_1001 4048-4355 44.4 µM -0.609999119145637 0.251238213346977 no 2532 0.27093119553498 3525 21824233
SGTC_1917 st066507 28.5 µM -0.61006037019539 0.251216711163158 no 2533 0.270910908656229 3453 3156428
SGTC_1631 benzylvanillin 81.9 µM -0.6102676982301 0.251143935869878 no 2534 0.270842245439364 3537 75506
SGTC_449 xestospongin c 11.1929 µM -0.610580568999261 0.251034134586402 no 2535 0.270738644864366 3511 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1314 1222-0010 41.1 µM -0.610729516296372 0.25098187079759 no 2536 0.270689331052154 3514 3526027
SGTC_62 0180-0423 3.232 µM -0.612503995948622 0.250359670719572 no 2537 0.270102177506962 3503 30102 YGL099W LSG1
SGTC_2481 5478948 45.16 µM -0.614041860333241 0.249821099070338 no 2538 0.26959383292283 3551 77792
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.614432822423747 0.249684279338362 no 2539 0.269464675975979 3570 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_404 fumagillin 50 µM -0.6146147019942 0.249620642963012 no 2540 0.269404601413058 3486 12015870 A methionine aminopeptidase binder.
SGTC_1621 st003705 32.4 µM -0.615016589650361 0.249480060289919 no 2541 0.269271882306947 3569 24207032
SGTC_3035 9091303 49.47 µM -0.615805468540427 0.249204228196101 no 2542 0.269011458874051 3571 25237002
SGTC_325 2810-4341 181 µM -0.616866393814589 0.248833530755984 no 2543 0.268661427372737 3555 774970
SGTC_1294 1000-1494 117 µM -0.617583577910196 0.248583106164593 no 2544 0.268424936248458 3507 712797 YDL207W GLE1
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.61808475264636 0.248408186919621 no 2545 0.268259736267225 3503 4620898
SGTC_1968 st069590 43.6 µM -0.618371011250904 0.248308306820377 no 2546 0.268165401083745 3515 6384066
SGTC_3172 9105863 49.47 µM -0.618628577834891 0.248218456117633 no 2547 0.26808053549191 3517 2348785
SGTC_2257 7960413 200 µM -0.618986475493787 0.248093634254132 no 2548 0.267962634271055 3535 2974689 YIL048W NEO1
SGTC_943 3253-1379 105 µM -0.620218324375734 0.247664265645073 no 2549 0.267557029450723 3554 668464
SGTC_2594 a-mangostin 100 µM -0.62105508941873 0.247372832482976 no 2550 0.267281688594947 3564 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2840 9008771 71.43 µM -0.621722755121684 0.247140425722085 no 2551 0.267062093150944 3502 2992978
SGTC_3332 9141069 11.198 µM -0.622797579849846 0.246766537040615 no 2552 0.266708774457836 3527 17332883
SGTC_2122 5258151 111.688 µM -0.626728719914657 0.245401633421086 no 2553 0.265418537287904 3519 2173356
SGTC_2626 ethyl orsellinate 100 µM -0.62830369422455 0.244855938122119 no 2554 0.264902506025851 3540 75653 A natural product.
SGTC_2173 5763948 167 µM -0.629098600358334 0.244580768144643 no 2555 0.264642253367632 3562 2867177
SGTC_1871 st057448 67.3 µM -0.62914591150778 0.244564395856676 no 2556 0.264626767775594 3652 691747
SGTC_14 0354-0009 295 µM -0.629819457176367 0.244331375647167 no 2557 0.264406356985745 3582 1713507
SGTC_69 0096-0274 206.684 µM -0.630030111532103 0.244258522129399 no 2558 0.264337441733972 3701 6741392
SGTC_1441 4106-0040 13 µM -0.631052560672351 0.243905080779002 no 2559 0.264003079011753 3573 2904180
SGTC_2612 dictamnine 15.46 µM -0.631489982262875 0.243753956727692 no 2560 0.263860098659929 3504 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1270 0831-1170 17.3 µM -0.63222956695762 0.243498553876176 no 2561 0.263618439846125 3570 6764716
SGTC_1073 triclabendazole 3.09 µM -0.632609236575597 0.243367497679527 no 2562 0.263494426925161 3589 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_793 0488-0545 106 µM -0.633560053541869 0.243039457400284 no 2563 0.263183988696568 3515 292548
SGTC_1433 4060-0023 7.6 µM -0.6338164654241 0.24295103398922 no 2564 0.263100303162939 3580 3840627
SGTC_3317 9138495 8.753 µM -0.637404400396884 0.241715565330745 no 2565 0.261930731412662 3584 17020139
SGTC_565 1418-0001 44.5 µM -0.638640018115062 0.241290883786354 no 2566 0.261528570793087 3609 2862145
SGTC_55 0767-0285 6.563 µM -0.638776080529254 0.241244143958587 no 2567 0.261484305488034 3556 3116166
SGTC_644 1498-1197 63.3 µM -0.639427088295732 0.241020579471331 no 2568 0.261272565804787 3611 6741615
SGTC_1199 1638-0010 4.46 µM -0.641184819863603 0.240417514882117 no 2569 0.260701305541597 3539 3111136
SGTC_1393 3470-5649 58.2 µM -0.641327174389575 0.240368710108451 no 2570 0.260655068675504 3513 4108395
SGTC_1011 4112-3381 17.4 µM -0.641448530898779 0.240327108549123 no 2571 0.260615655315378 3636 2877139
SGTC_742 0kpi-0133 140 µM -0.642156902030651 0.240084354019567 no 2572 0.260385656480082 3589 2728852
SGTC_2340 7987427 183.45 µM -0.64326580117831 0.239704609516509 no 2573 0.260025821499421 3547 2239331
SGTC_1258 0671-0043 57.1 µM -0.643484811922495 0.239629647674404 no 2574 0.259954783398776 3558 4298767
SGTC_1374 2889-5571 141 µM -0.643799162856656 0.239522075661573 no 2575 0.259852838348334 3561 2853281
SGTC_1862 st057513 3.81 µM -0.643905551326485 0.239485675119376 no 2576 0.259818340886807 3569 5393163
SGTC_124 0136-0217 7.121 µM -0.645146642953024 0.239061262028208 no 2577 0.259416079899695 3692 3976905
SGTC_2255 7941087 197.44 µM -0.648083627423755 0.238058548325225 no 2578 0.258465431445736 3626 935561
SGTC_2737 bleomycin 30.5 nM -0.649491516294701 0.237578700609643 no 2579 0.258010364123489 3612 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2818 7996756 12.99 µM -0.651091526806866 0.237034017489708 no 2580 0.257493702917548 3584 2241621
SGTC_2112 5488546 200 µM -0.65147042748782 0.23690513090995 no 2581 0.257371430422137 3565 600757
SGTC_710 3448-4187 58 µM -0.652398044874613 0.236589755938131 no 2582 0.257072212641655 3620 3946412
SGTC_1901 st060216 58.6 µM -0.653793814186661 0.236115652448896 no 2583 0.256622326157244 3607 688792
SGTC_667 1498-1044 59 µM -0.654488940012738 0.23587973317678 no 2584 0.256398425186646 3617 6739982
SGTC_1327 1436-0082 2.18 µM -0.65498327559482 0.235712039345684 no 2585 0.256239260985961 3576 15992205
SGTC_1132 3456-3614 2.5 µM -0.655385275145207 0.235575717222201 no 2586 0.256109864760023 3654 3125502
SGTC_2223 6903751 107.57 µM -0.657459262350069 0.234873098632404 no 2587 0.255442828446959 3576 5598863
SGTC_3082 9117008 49.47 µM -0.657724051438313 0.234783477700831 no 2588 0.255357732306018 3598 41448529
SGTC_1820 st053765 18.6 µM -0.659454511547156 0.234198249158413 no 2589 0.254801973673236 3593 3690829
SGTC_2466 5983409 37.09 µM -0.659898231710808 0.234048316551239 no 2590 0.254659569528306 3566 2879657
SGTC_863 0466-0191 129 µM -0.660092679167663 0.233982629703688 no 2591 0.254597178190585 3614 765160 YPR165W RHO1
SGTC_1863 st057641 20.1 µM -0.660567557917981 0.233822252498023 no 2592 0.254444839992333 3631 3921635
SGTC_2912 7964298 10.93 µM -0.661506879948532 0.233505201880328 no 2593 0.254143651974219 3631 2975850
SGTC_1041 0206-0046 107 µM -0.662278953535355 0.233244781492365 no 2594 0.253896231255713 3588 50494
SGTC_1864 st057645 30.4 µM -0.662547343585777 0.233154291311427 no 2595 0.253810251900664 3650 688666
SGTC_3245 9134821 49.47 µM -0.664151079283453 0.232613983390212 no 2596 0.253296810288917 3571 17014901
SGTC_2682 pyrogallin 40.03 µM -0.664843559469879 0.232380898112749 no 2597 0.253075279243868 3648 822798 An ATP competetive kinase inhibitor.
SGTC_1149 3909-7961 23.3 µM -0.66527804802776 0.232234717848843 no 2598 0.252936334248723 3586 735261
SGTC_3205 9113483 49.47 µM -0.665844749365518 0.232044132551114 no 2599 0.252755169307205 3612 17018033
SGTC_16 erodoxin 22.806 µM -0.667075542648326 0.23163050894793 no 2600 0.252361940733824 3649 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2779 methotrexate 400 µM -0.667494066436429 0.231489952427668 no 2601 0.252228299254457 3679 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_711 k292-0785 179 µM -0.668521540971605 0.231145088378635 no 2602 0.251900368198082 3646 4146315
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.67020323306653 0.230581260270256 no 2603 0.251364121579767 3605 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2686 alizarin 95.37 µM -0.670505899325543 0.230479865729274 no 2604 0.251267673523582 3596 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1156 4092-0367 4.88 µM -0.670979500631556 0.230321257209549 no 2605 0.251116794338456 3624 1357585
SGTC_826 1683-5028 118 µM -0.671450877066978 0.230163454419999 no 2606 0.250966671550203 3647 722377
SGTC_1983 st071813 46.9 µM -0.671780821965053 0.230053034689957 no 2607 0.250861619787728 3629 11838595
SGTC_2283 7944793 200 µM -0.671785673217232 0.230051411385609 no 2608 0.250860075362295 3613 2970533
SGTC_1531 st059297 52.4 µM -0.671938365820376 0.230000321344199 no 2609 0.25081146732225 3643 7566702
SGTC_2827 7993847 71.43 µM -0.672827535146773 0.229702936732901 no 2610 0.250528508970894 3584 2985692
SGTC_1794 st048918 76.9 µM -0.672882492988192 0.229684563032821 no 2611 0.250511025412772 3571 672303
SGTC_1162 k048-0130 20.1 µM -0.674291901315693 0.229213645991455 no 2612 0.25006287593392 3622 6797406
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.674490759476595 0.229147246334498 no 2613 0.249999679274407 3576 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2024 5144227 134 µM -0.675633292274066 0.228765958485106 no 2614 0.249636749303909 3633 3475211
SGTC_892 0929-0076 29 µM -0.676455177044367 0.228491898208891 no 2615 0.249375847592692 3640 5751038
SGTC_3213 9129884 49.47 µM -0.676495617190138 0.22847841806728 no 2616 0.249363013886783 3576 17190742
SGTC_2883 9059145 45.46 µM -0.67672436252513 0.228402177507789 no 2617 0.249290428019534 3633 16476510
SGTC_2822 7994718 71.43 µM -0.677114392952307 0.228272213784982 no 2618 0.24916668879838 3605 1018011
SGTC_2137 5261020 140 µM -0.678312904859911 0.227873112686235 no 2619 0.248786659052334 3627 763655
SGTC_273 hydroxyurea 18.1 mM -0.678919341125477 0.227671320796619 no 2620 0.248594485059457 3687 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3199 9111318 49.47 µM -0.680929387400328 0.227003196956799 no 2621 0.247958085993466 3604 8548020
SGTC_74 000s-0487 160.283 µM -0.681470839569012 0.22682341164958 no 2622 0.247786806036276 3602 677548
SGTC_780 0109-0199 192 µM -0.682106478183341 0.226612454950676 no 2623 0.247585812297847 3671 610414
SGTC_2399 5884133 200 µM -0.68222776580119 0.226572214419255 no 2624 0.247547470132738 3657 722445
SGTC_581 0958-0271 211 µM -0.682256227114549 0.226562772173484 no 2625 0.247538473232185 3656 4591145
SGTC_549 1661-1316 519 µM -0.682430117856944 0.226505087491709 no 2626 0.247483508455931 3670 2857282
SGTC_2238 6671620 73.2395 µM -0.683015171536972 0.226311068846615 no 2627 0.247298627902736 3621 729941
SGTC_1205 4161-2785 76 µM -0.683491789907877 0.226153079516406 no 2628 0.247148068168305 3633 3498106
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.687325892205999 0.224884421949498 no 2629 0.245938693009648 3676 66535 A nucleotide analog.
SGTC_2474 5321570 43.32 µM -0.687388942549623 0.224863593135423 no 2630 0.245918831873407 3670 2841384
SGTC_2208 7283366 200 µM -0.687637288672155 0.224781562108503 no 2631 0.245840610122623 3663 898663
SGTC_979 1426-2828 121 µM -0.687804820723003 0.224726234304538 no 2632 0.24578784998043 3729 747872
SGTC_2974 9094440 9.66 µM -0.688959954422475 0.224344959302019 no 2633 0.245424234238807 3710 25236134
SGTC_2958 9077254 16.72 µM -0.690145559887582 0.223954008624093 no 2634 0.245051327336162 3675 16457351
SGTC_3056 9094900 49.47 µM -0.690540268057967 0.223823940451671 no 2635 0.244927247961798 3611 25236784
SGTC_481 bay k-8644 50 µM -0.690665344221542 0.223782733067311 no 2636 0.244887936418085 3626 2303 A calcium channel antagonist.
SGTC_2903 5923464 63.88 µM -0.691510328967598 0.223504458806036 no 2637 0.244622445979414 3696 2876576
SGTC_381 3461-2219 42.7 µM -0.691641820138247 0.223461173234543 no 2638 0.244581145981932 3646 2883159
SGTC_917 harmaline 728.087 nM -0.692322296154564 0.223237243586437 no 2639 0.244367475622785 3668 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_304 1310-0298 97 µM -0.693162374632458 0.222960968551085 no 2640 0.244103828700237 3612 1550234
SGTC_424 splitomicin 100 mM -0.693222708004387 0.222941134326609 no 2641 0.244084899818321 3675 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2321 7390090 138.78 µM -0.694914250544731 0.22238545938516 no 2642 0.243554520728103 3617 649046
SGTC_236 1509-0011 5.31 µM -0.694979762454526 0.222363954500813 no 2643 0.243533992154482 3741 3107280
SGTC_1600 coumarin 106 71.1 µM -0.69570190717172 0.222126982505197 no 2644 0.24330776545865 3721 100336 A hepatotoxic, DNA x-linker.
SGTC_2673 kobusone 100 µM -0.69615547830229 0.221978216737111 no 2645 0.243165733059451 3724 6710676 An epoxy ketone and protein crosslinker.
SGTC_1807 st050092 58.9 µM -0.696424771035386 0.221889918944397 no 2646 0.24308142727236 3645 5008496
SGTC_3187 9109394 49.47 µM -0.697459766558686 0.221550743330089 no 2647 0.242757554888509 3627 17098090
SGTC_1518 st038567 90.8 µM -0.698027531308504 0.221364808601616 no 2648 0.242579988329287 3664 77966
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.698244211982048 0.221293872352951 no 2649 0.242512240708784 3649 2333 A French combination drug.
SGTC_546 peri-Naphthalide 147 µM -0.698676151101204 0.221152504256938 no 2650 0.242377220724307 3625 223824 A penicillin ester.
SGTC_2194 5927483 104.545 µM -0.698703168230403 0.221143663616744 no 2651 0.242368776785136 3692 760979
SGTC_697 0508-1955 564 µM -0.699920515724138 0.220745528748547 no 2652 0.241988472191298 3652 6243113
SGTC_1255 0566-0045 221 µM -0.700539622717223 0.2205432066841 no 2653 0.241795184735375 3708 2788469
SGTC_728 3030-5151 22.5 µM -0.700557112322549 0.220537492684051 no 2654 0.241789725634058 3704 3125388
SGTC_1764 st044502 93.5 µM -0.700797687913977 0.220458903239195 no 2655 0.241714640588966 3683 8407
SGTC_2434 5670830 169.91 µM -0.702430477477463 0.219925939997765 no 2656 0.241205372044567 3677 1549830
SGTC_1801 st050089 28.441 µM -0.703488962835398 0.219580832322128 no 2657 0.240875541336578 3708 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_887 0885-0007 9.62 µM -0.703650494898549 0.219528193911742 no 2658 0.240825228515293 3717 5719458
SGTC_1169 aniline yellow 25.8 µM -0.704448407245847 0.219268284781703 no 2659 0.240576784534783 3645 6051 A DNA damaging agent.
SGTC_257 daunorubicin 18.5 µM -0.705520145170368 0.218919459162871 no 2660 0.240243299875142 3726 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_861 0443-0273 110 µM -0.70860635420954 0.217916755402601 no 2661 0.239284396017305 3709 6149169
SGTC_1975 st070967 30.8 µM -0.709122043998902 0.217749467332059 no 2662 0.23912437220418 3684 261391
SGTC_2627 acetyl isogambogic acid 100 µM -0.710566393388568 0.217281319668162 no 2663 0.238676487310321 3671 6857789 A caspase activator and apoptosis inducer.
SGTC_1615 st002656 86.5 µM -0.710737721044187 0.217225826930062 no 2664 0.238623390007597 3704 1584458
SGTC_2428 5615643 7.78 µM -0.712425838022487 0.216679486574388 no 2665 0.238100560162893 3708 2253075
SGTC_2360 9040895 200 µM -0.714511418090067 0.216005610382469 no 2666 0.237455499126997 3682 4914414
SGTC_2555 cholic acid 100 µM -0.715133563350914 0.215804823063621 no 2667 0.237263258189887 3733 6708657 Influences liver metabolism.
SGTC_3114 9122766 49.47 µM -0.715470531660417 0.21569611717 no 2668 0.237159171735734 3677 17176985
SGTC_1240 0356-0016 42.1 µM -0.716518438107528 0.215358265739867 no 2669 0.236835643307816 3701 4305613
SGTC_1005 4092-0690 4.4 µM -0.719831002539318 0.214292296264933 no 2670 0.235814527025638 3720 1529343
SGTC_1117 retinoic acid 1.10837 µM -0.721316780971739 0.213815177707542 no 2671 0.23535731731702 3713 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_466 geldanamycin 89.2 µM -0.722207020180813 0.213529597487593 no 2672 0.235083603928596 3600 5288382 HSP90 inhibitor.
SGTC_3017 9080681 49.47 µM -0.722257189368161 0.213513510311187 no 2673 0.235068184120845 3720 16451914
SGTC_3157 9099274 49.47 µM -0.722517120997003 0.213430172335197 no 2674 0.234988301485852 3671 17217662
SGTC_1617 st002906 78 µM -0.722739628795034 0.213358848064439 no 2675 0.234919931923548 3733 5150859
SGTC_2067 5224629 34.075 µM -0.723228639611594 0.213202145809696 no 2676 0.234769713101927 3688 2835000
SGTC_840 0245-0196 390 µM -0.726654113419399 0.212106344901807 no 2677 0.233718934898974 3795 3827528
SGTC_739 1486-1183 203 µM -0.727118681792814 0.211957984599397 no 2678 0.23357662767205 3691 4346692
SGTC_1454 4239-0054 42.6 µM -0.72809966553425 0.211644906093329 no 2679 0.233276289290025 3825 1340767
SGTC_2443 5493264 126.67 µM -0.729887593324994 0.211074990192006 no 2680 0.23272944827133 3756 5340055
SGTC_540 1187-0821 17.3 µM -0.729899777654577 0.211071109430513 no 2681 0.232725724117238 3701 847520
SGTC_1036 k216-0215 33.5 µM -0.732662832242403 0.210192145185919 no 2682 0.231882049220651 3727 622330
SGTC_2850 9015429 58.44 µM -0.734269536140031 0.209682021450581 no 2683 0.231392240383693 3783 6457570
SGTC_2655 perillic acid 100 µM -0.735682155378111 0.209234121021268 no 2684 0.230962075942296 3742 5702197 An apoptosis inducer.
SGTC_3190 9110366 49.47 µM -0.73646459761116 0.208986273932823 no 2685 0.230724002419941 3676 17123768
SGTC_2167 5876490 200 µM -0.737146173906745 0.208770518214334 no 2686 0.230516731119143 3874 686534
SGTC_47 0149-0135 24.25 µM -0.73775810984549 0.208576919306515 no 2687 0.230330726551491 3734 5239155
SGTC_602 3130-1533 38.1 µM -0.73801361660282 0.208496115660159 no 2688 0.230253087344156 3752 720941
SGTC_1242 0402-0103 60.1 µM -0.73819412502478 0.208439041258428 no 2689 0.230198246226222 3698 432868
SGTC_2451 5856223 45.7 µM -0.738732192018935 0.208268966190846 no 2690 0.230034816903504 3716 2179896
SGTC_1786 berberine 21.6 µM -0.739090425509548 0.208155779264351 no 2691 0.229926045171396 3707 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1361 1608-0041 5.61 µM -0.739832148000755 0.20792154114169 no 2692 0.229700924825188 3705 X1361
SGTC_2834 9001755 58.44 µM -0.74011294032548 0.207832906735938 no 2693 0.229615733712227 3693 2989575
SGTC_1349 flufenamic acid 69 µM -0.740126756008305 0.207828546278119 no 2694 0.229611542553861 3703 3371 A non-steroidal anti-inflammatory.
SGTC_1558 st069300 45.6 µM -0.740565998481216 0.207689942262094 no 2695 0.229478315256173 3679 24208000
SGTC_1649 st011737 51.3 µM -0.741291119408929 0.207461248140671 no 2696 0.229258472547521 3751 1761035
SGTC_2628 lathosterol 100 µM -0.743011336083333 0.206919308966562 no 2697 0.228737408625967 3787 6710616
SGTC_2639 lactacystin 53 µM -0.745358958407731 0.206181064649612 no 2698 0.228027373873668 3763 3870 A proteasome inhibitor.
SGTC_1421 4029-0249 71.4 µM -0.747906152021518 0.205381831059181 no 2699 0.227258383270871 3821 2894095
SGTC_2412 st077135 33.4 µM -0.750530619619282 0.204560278890594 no 2700 0.226467594745823 3822 13258915
SGTC_2059 5238311 157 µM -0.751003185833354 0.204412556805208 no 2701 0.226325369240396 3763 703021
SGTC_2841 9004761 38.96 µM -0.751158872406556 0.204363903787933 no 2702 0.22627852420897 3724 2991039
SGTC_1909 st060837 51.5 µM -0.75167486100833 0.204202703451323 no 2703 0.226123305913523 3782 678937
SGTC_2047 4141938 200 µM -0.753961507490168 0.203489242606657 no 2704 0.225436167760601 3746 3807862
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.755115764565359 0.20312966613744 no 2705 0.225089762501993 3765 688798
SGTC_457 grayanotoxin iii 135 µM -0.756400954876982 0.202729747720261 no 2706 0.224704417833386 3705 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2662 daunorubicin 22.37 µM -0.756671506805589 0.202645618851724 no 2707 0.22462334467121 3661 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1964 st076914 61 µM -0.757211922778146 0.20247763748994 no 2708 0.224461454160914 3811 24208661
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.759345746704602 0.201815179524445 no 2709 0.223822879302074 3775 75037 A free radical scavenger.
SGTC_1873 rapamycin 2 nM -0.759427362745125 0.201789867148876 no 2710 0.223798475149272 3740 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2924 9010168 62.78 µM -0.759674788926892 0.201713142081872 no 2711 0.223724501064258 3860 2993929
SGTC_1445 4239-0156 97.7 µM -0.75988534572231 0.201647863707284 no 2712 0.223661560930339 3854 4008346
SGTC_1825 st052143 62.6 µM -0.760994574405915 0.201304181407103 no 2713 0.22333015395533 3774 674173
SGTC_1900 st060200 72.8 µM -0.76201791030307 0.200987423665367 no 2714 0.223024657362077 3762 688945
SGTC_2647 atorvastatin 60.16 µM -0.762066549934417 0.200972375470002 no 2715 0.22301014289408 3759 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_237 nikkomycin 200 µM -0.762240624796487 0.200918525490654 no 2716 0.222958201924707 3782 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_309 k408-0051 1.48 µM -0.762916952015563 0.200709386147799 no 2717 0.222756462827341 3752 3640463
SGTC_918 glabranin 770.725 nM -0.76335680628201 0.200573441030693 no 2718 0.222625316201999 3807 124049 Also referred to as licorice root.
SGTC_1530 rhein 70.4 µM -0.764204290427139 0.200311666283119 no 2719 0.222372755096208 3828 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_302 1094-0063 18.9 µM -0.764268408108042 0.200291869678939 no 2720 0.222353653860552 3728 5440289
SGTC_3263 9137018 49.47 µM -0.76460621296729 0.20018759041808 no 2721 0.222253034201841 3766 43844957
SGTC_166 k072-0058 166.424 µM -0.767158900905672 0.199400639358465 no 2722 0.221493522685098 3764 5846229
SGTC_1502 4534-4282 27.7 µM -0.768190344700761 0.199083191507429 no 2723 0.22118705444529 3751 3278949
SGTC_102 gallobenzophenone 83.616 µM -0.768220207729818 0.199074005089254 no 2724 0.221178184993206 3796 70837
SGTC_3330 9141424 71.43 µM -0.768687896007218 0.198930168877134 no 2725 0.221039306049066 3850 27261020
SGTC_1746 st038117 42 µM -0.769505818425499 0.198678769745235 no 2726 0.220796545889942 3845 2898218
SGTC_1979 st071809 45.3 µM -0.769808787319113 0.198585696948505 no 2727 0.220706663195759 3897 4976333
SGTC_726 3448-4391 34.2 µM -0.771036420182441 0.198208834332796 no 2728 0.220342672232957 3841 1356692
SGTC_347 4534-1311 26.2 µM -0.771939525695508 0.197931871966087 no 2729 0.220075122892218 3784 2862016
SGTC_731 3966-0296 387 µM -0.771982070999663 0.197918830036271 no 2730 0.220062523239923 3810 660956
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.77207120079111 0.197891509679541 no 2731 0.220036129086044 3847 688801
SGTC_1836 st055642 81 µM -0.772099027241792 0.197882980691058 no 2732 0.220027889164794 3815 8571
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.772300854245526 0.197821126045677 no 2733 0.219968129794401 3766 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1614 st002383 48.6 µM -0.773259545185954 0.197527472162072 no 2734 0.219684396247387 3779 1947235
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.776295963456701 0.196599136226811 no 2735 0.218787127944844 3847 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_646 4092-0839 27.3 µM -0.777790049703374 0.196143315362389 no 2736 0.21834639743246 3826 877796
SGTC_2657 nystatin 74.44 µM -0.779003262224798 0.195773656322818 no 2737 0.217988896538625 3828 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_518 1021-0119 62.6 µM -0.781051707354779 0.195150467098532 no 2738 0.217386041799346 3802 1097762
SGTC_1231 0242-0792 125 µM -0.78181726622183 0.194917874415153 no 2739 0.217160986163742 3813 3707635
SGTC_3053 9095903 49.47 µM -0.781992768348819 0.194864576985751 no 2740 0.217109411790801 3875 17174018
SGTC_2620 irigenin 100 µM -0.78299436143097 0.194560577472045 no 2741 0.21681521160063 3826 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2241 6772625 37.8075 µM -0.783670598097177 0.194355492140065 no 2742 0.216616709499479 3730 2285411
SGTC_145 3737-0113 38.366 µM -0.783790286167609 0.194319207515359 no 2743 0.216581587288949 3807 6849351
SGTC_1671 st016596 74.5 µM -0.784768939725894 0.194022673763919 no 2744 0.216294527102502 3856 2829167
SGTC_2402 5553605 200 µM -0.784974699801128 0.193960363194725 no 2745 0.216234201271546 3845 6758546
SGTC_2084 5306078 60.6385 µM -0.785533626815114 0.193791164221956 no 2746 0.216070381263923 3755 679340
SGTC_3350 9150499 3.57 µM -0.786641325920976 0.193456106348517 no 2747 0.215745930124691 3788 4910996 YPR165W RHO1
SGTC_1416 3966-0321 25.3 µM -0.78922032059313 0.19267737999689 no 2748 0.214991623604676 3834 582530 YLR208W SEC13
SGTC_452 diindolylmethane 8 µM -0.789952003624773 0.192456797916748 no 2749 0.214777899552312 3818 3071 Inhibits expression of several cancer promoting factors.
SGTC_375 3970-0961 9.27 µM -0.791655987623791 0.191943692928216 no 2750 0.214280645901942 3790 2898222
SGTC_2171 5739187 198.077 µM -0.792555438947009 0.191673187402408 no 2751 0.214018439847951 3754 2262761
SGTC_1775 st081588 35.1725 µM -0.792692989783183 0.191631840262556 no 2752 0.213978357803677 3846 1426443 YGL099W LSG1
SGTC_1068 loratadine 26.9 µM -0.793277728310885 0.191456131570313 no 2753 0.213808014921826 3864 3957 A H1 histamine antagonist.
SGTC_421 streptovitacin 30 mM -0.793422868313464 0.19141253359598 no 2754 0.213765745753878 3921 91467 include heat shock
SGTC_2204 7233102 200 µM -0.793617622265704 0.191354041862571 no 2755 0.213709035147486 3727 2172480
SGTC_1790 st045711 43.5 µM -0.794178325305444 0.191185703413765 no 2756 0.213545812388071 3800 585119
SGTC_3033 9090887 49.47 µM -0.79588114525863 0.190675026916115 no 2757 0.21305056063066 3863 19325384
SGTC_487 nimodipine 119 µM -0.795976961057604 0.190646316615385 no 2758 0.213022713288563 3697 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2703 st077852 53.4 µM -0.797845635837145 0.190086916470188 no 2759 0.212480037325076 3832 6281836
SGTC_1 0258-0098 57.368 µM -0.798461803231065 0.189902684057609 no 2760 0.212301275300254 3767 6790032 YDR047W HEM12
SGTC_1191 1487-1166 10.6 µM -0.799352958390589 0.189636425310493 no 2761 0.212042889580451 3889 3955771
SGTC_938 3126-1755 342 µM -0.799479669304126 0.189598585364445 no 2762 0.212006165361087 3865 1777771
SGTC_1892 st058411 7.36 µM -0.800478003954024 0.189300613094045 no 2763 0.211716951354019 3826 3934738
SGTC_290 2043-6722 48.1 µM -0.801500289746721 0.188995791062594 no 2764 0.21142103819879 3844 773758 YLR208W SEC13
SGTC_782 0083-0095 30.5 µM -0.802658087823719 0.188650927765561 no 2765 0.21108619203792 3821 3591729 An indicator and reagent.
SGTC_2195 6536160 144.242 µM -0.805365321207153 0.187846062886247 no 2766 0.210304448719764 3764 3834386
SGTC_955 1216-0110 33 µM -0.805519025593681 0.187800430027891 no 2767 0.210260115950824 3799 3619719
SGTC_3090 9117696 49.47 µM -0.805626225838649 0.187768607704893 no 2768 0.210229199563645 3788 7923821
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.806077351854484 0.187634727741912 no 2769 0.210099124769346 3839 6708739 YPR165W RHO1
SGTC_1636 st007707 68.9 µM -0.806105204898821 0.187626463770918 no 2770 0.210091095350403 3843 403051
SGTC_1137 ixabepilone 100 µM -0.806406631996315 0.18753704503158 no 2771 0.210004212092877 3823 154225 A novel microtubule stabilizer.
SGTC_3308 9128332 17.569 µM -0.806923810499257 0.187383684723521 no 2772 0.20985518991271 3857 17332805 YDL196W YDL196W
SGTC_230 MPP+ 141.667 µM -0.806978343778799 0.187367518345444 no 2773 0.209839480067561 3833 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_705 1124-0212 310 µM -0.80854100023699 0.18690463559438 no 2774 0.209389606718142 3795 9554485
SGTC_1463 k081-0032 34.1 µM -0.809566913207207 0.186601129594158 no 2775 0.209094565373755 3627 977755
SGTC_1670 st016595 4.04 µM -0.810817575550969 0.186231546796188 no 2776 0.208735219891103 3849 597879
SGTC_1780 st038448 24.544 µM -0.813437311460164 0.18545886103724 no 2777 0.207983687228957 3922 728868 YDL195W SEC31
SGTC_1685 st024049 53.0905 µM -0.816632859805428 0.184519039034763 no 2778 0.207069135339795 3880 1941139
SGTC_683 panaxydol 45 µM -0.819638232534133 0.183637856431141 no 2779 0.206211185760943 3830 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1279 0874-0590 65.2 µM -0.821457497848976 0.183105719670435 no 2780 0.205692862010638 3905 3523074
SGTC_2635 hydroquinidine 100 µM -0.823889810507095 0.18239577048285 no 2781 0.205001085313608 3811 442912 An experimental heart treatment.
SGTC_1591 genipin 88.4 µM -0.824744785516063 0.182146627394541 no 2782 0.20475824982988 3910 442424 A DNA cross-linking agent.
SGTC_2982 9019404 25.97 µM -0.825228555555144 0.182005749181396 no 2783 0.204620922186469 3830 22333232
SGTC_1165 k072-0275 30.3 µM -0.825553266439742 0.181911228655728 no 2784 0.204528777355584 3844 6153523 YGL055W OLE1
SGTC_1331 1472-0049 76.2 µM -0.825766479423744 0.181849180903063 no 2785 0.20446828627388 3816 24051409
SGTC_1981 st071826 47 µM -0.826731557201823 0.181568496305446 no 2786 0.204194615335051 3904 11838600
SGTC_1459 k035-0031 35.7 µM -0.830337101274246 0.180522255318321 no 2787 0.203174108490228 3720 3877128 YMR208W ERG12
SGTC_601 0986-0029 62.9 µM -0.833681230102501 0.179555257954971 no 2788 0.202230318950437 3847 24747981
SGTC_981 1488-1094 54.9 µM -0.835173218295821 0.179124882825827 no 2789 0.201810093266449 3853 3449522
SGTC_3010 9080089 71.4286 µM -0.835787901509965 0.178947761770879 no 2790 0.201637116962244 3887 17027233
SGTC_652 0437-0092 114 µM -0.837380519420355 0.178489361638624 no 2791 0.201189356104488 3845 3091274
SGTC_1951 sophoraflavanone G 9.2 µM -0.837701349377418 0.178397107361801 no 2792 0.201099227705313 3873 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_818 4072-2707 53.5 µM -0.839217785631469 0.177961464577394 no 2793 0.200673554253834 3801 882871
SGTC_613 3914-0030 117 µM -0.841314171940263 0.17736031915626 no 2794 0.200085976671989 3636 1145395
SGTC_341 1486-1430 230 µM -0.844073861815955 0.176570926643233 no 2795 0.199314066365254 3870 2054753 YPL210C SRP72
SGTC_1447 4239-0816 81.9 µM -0.844532653561117 0.176439907783093 no 2796 0.199185912211993 3893 1341554
SGTC_506 n9-isopropylolomoucine 153 µM -0.845710294597404 0.176103886081801 no 2797 0.198857189395675 3878 6610355
SGTC_3193 9111931 49.47 µM -0.846541672063242 0.1758669094591 no 2798 0.198625318486379 3925 17087244
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.850060638535956 0.174866097958643 no 2799 0.1976456869606 3934 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_184 1494-0393 24.714 µM -0.850195312704093 0.174827867909434 no 2800 0.19760825364981 3892 3090647
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.851760865474238 0.1743838426914 no 2801 0.197173415525877 3964 5393153
SGTC_1550 gossypolone 36.6 µM -0.852548271538682 0.174160788027344 no 2802 0.196954929548492 3906 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1193 1488-0126 41.5 µM -0.853815795111291 0.17380210781334 no 2803 0.196603530667753 3901 1384710
SGTC_2970 9090938 41.86 µM -0.85407702292051 0.173728244746117 no 2804 0.1965311570317 3968 17217104
SGTC_1557 sumaresinolic acid 42.3 µM -0.854100856573517 0.173721506692442 no 2805 0.196524554678822 3874 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1846 st056244 14.8 µM -0.856079059316196 0.173162825148291 no 2806 0.195977025359992 3942 5393182
SGTC_2032 5185112 25.99 µM -0.858490087276718 0.172483454706862 no 2807 0.195310950905405 3810 5718189
SGTC_1339 1486-1321 22.7 µM -0.858801086462601 0.172395946461201 no 2808 0.195225134032742 3928 3469382
SGTC_2770 toltrazuril 17.5 µM -0.858971855886384 0.172347907794692 no 2809 0.195178021797968 3830 68591 Kills coccidiodes.
SGTC_527 4476-4215 268 µM -0.860934958174586 0.171796286452365 no 2810 0.194636933328573 3902 4418754
SGTC_2859 9028643 45.46 µM -0.861283310929768 0.171698519100383 no 2811 0.194541012550213 3824 17151580
SGTC_179 1273-0063 6.77 µM -0.861518444157022 0.171632547603469 no 2812 0.194476283635356 3911 3108139
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.862290030309419 0.171416176908014 no 2813 0.194263968780441 3953 6710655
SGTC_1391 3442-0225 151 µM -0.864722030626016 0.170735328864792 no 2814 0.193595687311787 3874 5227075
SGTC_1827 berberine 7.24 µM -0.86688570387791 0.170131057041409 no 2815 0.193002318655692 3871 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1404 3909-7820 48.3 µM -0.867685557499387 0.169908020889373 no 2816 0.192783247187498 3868 23741373
SGTC_1986 st071812 45 µM -0.868139211838787 0.169781604446099 no 2817 0.192659063595402 3863 11838594
SGTC_2233 sulbentine 40.3845 µM -0.869019860046311 0.169536373076799 no 2818 0.192418134064098 3898 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_956 1185-0240 191 µM -0.870980120393275 0.168991321876573 no 2819 0.191882503857521 3930 1416193
SGTC_2369 9071472 200 µM -0.871426314238789 0.168867414921497 no 2820 0.191760711521499 4017 17296037
SGTC_2010 4012422 159 µM -0.875426209689358 0.167759261516687 no 2821 0.190671021998266 3946 952393
SGTC_229 benomyl 22.8748 µM -0.876060831359331 0.167583873751298 no 2822 0.190498482336723 3948 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1519 esterone 74 µM -0.876474202387844 0.167469695656844 no 2823 0.190386147429961 3916 698 A steroid.
SGTC_3027 9089541 49.47 µM -0.877216332877346 0.167264836005181 no 2824 0.190184573192154 3957 9943819
SGTC_2315 7733312 200 µM -0.878464979422477 0.166920521002965 no 2825 0.189845717332945 3880 726316
SGTC_1929 genistein trimethyl ether 50.5 µM -0.879311083611323 0.166687467320408 no 2826 0.189616313966239 3879 136420
SGTC_598 3937-0236 20.2 µM -0.880180482317577 0.166448216154885 no 2827 0.189380772501552 4012 1379313
SGTC_599 1935-0052 86.5 µM -0.883056613816651 0.165658309900289 no 2828 0.18860284199377 3950 9557311
SGTC_2142 5622915 118.518 µM -0.883402074303854 0.165563595299788 no 2829 0.188509535220568 3960 5322196
SGTC_632 0781-2353 4.65 µM -0.884117598993968 0.16536753193955 no 2830 0.188316366917874 4010 6811515 YHR007C ERG11
SGTC_443 clozapine 122 µM -0.88449763146332 0.165263459054733 no 2831 0.188213820230543 3826 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_203 k066-0004 30.888 µM -0.885080016400006 0.165104053685908 no 2832 0.188056738308676 4014 6795412
SGTC_410 α-linolenic acid 100 µM -0.885466345835141 0.16499836586522 no 2833 0.187952581490844 4022 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_509 pifithrin 175 µM -0.887515311683365 0.164438564444145 no 2834 0.187400763141322 3989 4817 A p53 inhibitor.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.887702915450003 0.164387370496157 no 2835 0.187350288623485 3975 2374 Ca(2+)-ATPase inhibitor.
SGTC_2015 5119600 184 µM -0.887938578765794 0.164323076539805 no 2836 0.187286895665326 3997 2828786
SGTC_288 1315-0019 35.1 µM -0.888514023848169 0.164166151424071 no 2837 0.187132157833022 4022 6811474
SGTC_429 1112-0049 25.5 µM -0.891716626470862 0.163294571176487 no 2838 0.186272419731454 3932 2836170
SGTC_2732 terfenadine 20 µM -0.891866367734084 0.16325389317159 no 2839 0.186232281699111 3959 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2792 7535235 81.82 µM -0.891954001320451 0.163230090099468 no 2840 0.186208794068899 3965 1281891
SGTC_1173 0443-0020 122 µM -0.892893895109457 0.162974937554393 no 2841 0.185956998358407 3955 5331295
SGTC_660 4031-1742 102 µM -0.893355370946907 0.162849755874811 no 2842 0.185833447194126 3889 6738706
SGTC_972 1319-0219 195 µM -0.893647374984148 0.162770578063743 no 2843 0.185755295108602 3931 23903702
SGTC_3116 9124943 49.47 µM -0.895126105380693 0.162370000177677 no 2844 0.185359840193316 3951 41905195 YPL160W CDC60
SGTC_1757 st041620 31.8375 µM -0.895976667294005 0.162139879746926 no 2845 0.18513261251032 4049 5289815
SGTC_958 1222-0007 33 µM -0.89653171894874 0.161989824504097 no 2846 0.18498442375189 4050 7312461
SGTC_858 0438-0351 2.77 µM -0.898956605878364 0.161335330509704 no 2847 0.184337887478479 3954 2799119
SGTC_622 1348-1566 26.3 µM -0.899077279225653 0.161302805040202 no 2848 0.184305749674827 4006 7340407
SGTC_105 0111-0055 734.78 µM -0.900395498129892 0.16094777989855 no 2849 0.183954907857881 3984 5179370
SGTC_1115 galangin 695.678 nM -0.900830544719422 0.160830724375439 no 2850 0.183839212248422 3990 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2567 aureobasidin a 60 nM -0.90253826368012 0.16037177554579 no 2851 0.183385502406241 4136 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_559 1550-0661 158 µM -0.903932926482951 0.159997595940776 no 2852 0.183015484230375 4025 5830875
SGTC_3067 9117431 49.47 µM -0.904799902481492 0.1597652795157 no 2853 0.18278570167546 4025 17150885
SGTC_3169 9102970 49.47 µM -0.90536235294287 0.159614682382431 no 2854 0.182636726661241 4027 17027839
SGTC_2191 5911152 200 µM -0.906122153684346 0.159411391917075 no 2855 0.182435600342042 3981 2875902
SGTC_412 gemfibrozil 100 µM -0.906825725101614 0.159223297262945 no 2856 0.182249481882509 3914 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_3077 9117319 49.47 µM -0.908304421407576 0.158828452637819 no 2857 0.181858703589409 3941 17154678
SGTC_990 3985-0011 41.3 µM -0.908417039081185 0.158798407550654 no 2858 0.181828963363974 3973 5399565 YGL099W LSG1
SGTC_2645 abamectin 100 µM -0.908443551406401 0.158791334912054 no 2859 0.181821962396196 3932 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1336 1486-0901 104 µM -0.910054351115147 0.158362012567109 no 2860 0.181396923507079 4005 5006114
SGTC_1426 4048-4480 71.7 µM -0.911927670220157 0.157863680283919 no 2861 0.180903397187385 3971 14224343
SGTC_1562 morin hydrate 59.1 µM -0.91381467083969 0.157362750737585 no 2862 0.180407118107891 4066 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_454 lyso-paf C-16 6.67 µM -0.914880886014038 0.157080172152755 no 2863 0.180127082724193 3940 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_328 k915-0120 63.5 µM -0.916663766890249 0.156608402016746 no 2864 0.179659429160521 3979 6624543
SGTC_879 0831-1030 162 µM -0.91797801623338 0.156261234837597 no 2865 0.179315187612229 4026 1549252
SGTC_1225 1216-0074 20.6 µM -0.919221126371437 0.155933326433167 no 2866 0.17898996153434 4010 4241466
SGTC_738 1315-0003 72.4 µM -0.919896481664264 0.155755371058591 no 2867 0.1788134288254 4057 6251474
SGTC_2147 5545932 89.7195 µM -0.921093406293682 0.155440311853126 no 2868 0.178500831230507 4025 797404
SGTC_2289 7946404 165.07 µM -0.921420400754003 0.155354312267667 no 2869 0.178415490865502 4034 1246120 YPR165W RHO1
SGTC_1082 camptothecin 424.86 nM -0.922420507627862 0.155091478942599 no 2870 0.178154638409255 3912 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2748 diazoxide 86.69 µM -0.924753917014008 0.154479388994348 no 2871 0.177546963228537 4012 3019 A potassium channel activatior.
SGTC_2543 pimpinellin 60.67 µM -0.925716877815415 0.154227255361074 no 2872 0.177296567170304 3839 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_619 1652-1634 108 µM -0.927968434681849 0.153638789186131 no 2873 0.176711971773322 3973 5400454
SGTC_441 propafenone 146 µM -0.928331763835807 0.153543969087903 no 2874 0.176617751125746 3999 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_829 1635-0120 117 µM -0.929263330998381 0.15330102975106 no 2875 0.176376316844489 4016 285054
SGTC_772 k072-0172 35.3 µM -0.933502130536268 0.152198829051666 no 2876 0.175280385468636 4051 5861980
SGTC_61 0978-8327 98.565 µM -0.934398302891436 0.151966475871476 no 2877 0.175049236424764 3947 6150059 YHR072W ERG7
SGTC_2558 carylophyllene oxide 100 µM -0.934440839896082 0.151955453040705 no 2878 0.175038269697511 4121 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_502 l-744,832 89.3 µM -0.934595577023596 0.151915359700561 no 2879 0.174998379642246 4021 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_91 0417-1751 58.384 µM -0.934972597651826 0.151817700764465 no 2880 0.17490121074007 4125 6795624
SGTC_391 gliotoxin 8.33 µM -0.935970137123558 0.151559511249941 no 2881 0.174644281725034 4112 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1932 st074806 40.9 µM -0.936525885438441 0.151415795619661 no 2882 0.174501245657843 4119 17251235
SGTC_2796 7949634 45.45 µM -0.937710417530456 0.151109780012611 no 2883 0.174196624359215 3965 2971588
SGTC_3321 9137793 26.8275 µM -0.937973931944889 0.151041758894499 no 2884 0.174128903410651 3978 4904192
SGTC_77 0828-0286 12.516 µM -0.938007071576856 0.151033205985964 no 2885 0.174120387993674 3934 745345
SGTC_2060 5238662 140 µM -0.938888883976522 0.150805740045789 no 2886 0.173893898514558 4003 790130
SGTC_2743 auranofin 4.32 µM -0.939702735355748 0.150596007322691 no 2887 0.173685030838395 3976 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1438 4092-1045 4 µM -0.94099743748938 0.150262757981301 no 2888 0.173353086184053 4004 1351342
SGTC_3346 9158254 43.5805 µM -0.941130724650743 0.150228478508498 no 2889 0.173318936047895 4032 17639500
SGTC_3123 9126162 49.47 µM -0.942505801867964 0.149875133393774 no 2890 0.172966871052736 4088 25239884
SGTC_1495 4469-0029 237 µM -0.943404469699971 0.149644507993827 no 2891 0.172737028907296 4026 793680
SGTC_108 0509-0257 621.132 µM -0.944672580918287 0.149319475241566 no 2892 0.172413029743916 3985 536624
SGTC_2324 6149169 200 µM -0.947355114323128 0.148633462599591 no 2893 0.171728927584286 3933 2888231
SGTC_905 2-aminofluorene 215 µM -0.947834303282025 0.148511140271184 no 2894 0.17160690714015 4025 1539 An established DNA mutagen. YPR165W RHO1
SGTC_411 enrofloxacin 100 µM -0.948049518593597 0.148456224276829 no 2895 0.171552122848204 4118 71188 A bacterial gyrase inhibitor.
SGTC_3233 9132340 49.47 µM -0.948350724092739 0.148379389170519 no 2896 0.171475468028359 4031 17682950
SGTC_72 0744-0168 198.391 µM -0.949597893728185 0.14806152931252 no 2897 0.171158304560599 3927 677577
SGTC_1107 amlodipine 47 µM -0.950887229058406 0.147733402315659 no 2898 0.170830812728695 3784 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1683 st010134 710 nM -0.952576799371209 0.147304155974066 no 2899 0.170402268450822 4025 3818134
SGTC_2881 9058953 51.95 µM -0.95297356570924 0.147203476219567 no 2900 0.170301732163503 3984 17122249
SGTC_1534 6-azauridine 81.6 µM -0.953865450715012 0.146977328157716 no 2901 0.170075876917097 4057 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3296 9122258 64.045 µM -0.95459196933779 0.146793283002291 no 2902 0.169892039940975 4040 4730474
SGTC_2199 6590217 200 µM -0.955038872320264 0.146680148247724 no 2903 0.169779019719733 3941 703109
SGTC_2445 5742597 35.57 µM -0.95577315050283 0.146494390718558 no 2904 0.169593428020823 3997 1774255
SGTC_1430 4049-0248 69.1 µM -0.957995129348281 0.145933237276282 no 2905 0.169032607307431 4052 22774488
SGTC_3212 9128307 49.47 µM -0.959087439528335 0.145657908188589 no 2906 0.168757348732212 4005 27243542
SGTC_2268 7933382 153.85 µM -0.960204277538242 0.145376757900312 no 2907 0.168476207220808 4056 935025 YOR257W CDC31
SGTC_2424 5537928 59.2 µM -0.961246931976294 0.145114612108456 no 2908 0.168214011905525 4078 5382802
SGTC_2248 tofa 1.1 µM -0.961526878784242 0.145044281658524 no 2909 0.168143658675994 3991 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2803 7707263 71.43 µM -0.961818208785904 0.144971115798161 no 2910 0.168070464849728 4018 2199229
SGTC_2937 9044753 11.33 µM -0.962225867856743 0.144868776273795 no 2911 0.167968078901427 4008 6465530 YGL099W LSG1
SGTC_2311 7694451 200 µM -0.965247562297373 0.144111721007077 no 2912 0.167210414733081 4031 2163142
SGTC_679 0422-0091 41.4 µM -0.967247119913623 0.143612221147558 no 2913 0.166710255888644 4031 627384 YHR062C RPP1
SGTC_3102 9121669 49.47 µM -0.969750771967442 0.142988445201213 no 2914 0.166085368089108 4081 41905072
SGTC_3254 9136651 49.47 µM -0.969829364830222 0.142968893753026 no 2915 0.166065776585764 4035 16454030
SGTC_2817 7995342 71.43 µM -0.972009508568632 0.142427262180611 no 2916 0.165522909089891 4056 18879975
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.974379319102772 0.141840086382163 no 2917 0.16493411704395 4136 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_864 0469-0573 172 µM -0.976476174278484 0.141321910390966 no 2918 0.164414274596858 4043 689425
SGTC_1297 1068-0111 14.1 µM -0.977012990965051 0.141189458520933 no 2919 0.164281360484638 4025 767057
SGTC_125 0133-0007 11.75 µM -0.979203439794299 0.140649869068806 no 2920 0.163739734680727 4139 26541
SGTC_2052 5265182 7.135 µM -0.979429337828302 0.140594301653636 no 2921 0.163683943550933 4071 1239884
SGTC_2653 dihydrofissinolide 100 µM -0.98039350908657 0.140357298011301 no 2922 0.163445956277569 4104 6857746
SGTC_2452 5863136 48.41 µM -0.981980973797638 0.139967673516099 no 2923 0.163054610792737 4029 2184096
SGTC_2189 6047310 154.431 µM -0.982717377180051 0.139787181782393 no 2924 0.162873277894776 4048 711535
SGTC_1010 4112-3296 15.2 µM -0.983027473533076 0.139711224837294 no 2925 0.162796958627242 4149 704384
SGTC_3282 9108498 15.4605 µM -0.985022678789543 0.139223177913625 no 2926 0.162306465633124 4066 16459645
SGTC_2310 7668677 200 µM -0.985170722390956 0.139187011278327 no 2927 0.162270109586069 4089 2197143
SGTC_2264 7948757 110.76 µM -0.985249598452676 0.139167744689392 no 2928 0.162250741634516 4033 2971411
SGTC_2874 9043904 71.43 µM -0.986306957263907 0.138909645155282 no 2929 0.161991253377535 4022 4463428
SGTC_1904 st060225 78 µM -0.988234616780452 0.138439945845136 no 2930 0.161518879153161 4017 66595
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.988813452396434 0.138299116567209 no 2931 0.161377210612263 4119 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_202 3594-0513 34.79 µM -0.989697451771861 0.138084230212692 no 2932 0.161161010451786 4083 708429
SGTC_529 4076-0302 30.3 µM -0.990239123419149 0.137952670911774 no 2933 0.161028626971776 4030 5816522
SGTC_357 1325-0123 420 µM -0.991360615082295 0.13768055880168 no 2934 0.160754762269903 4107 1098503
SGTC_2416 tofa 880 nM -0.991771580614344 0.137580936324955 no 2935 0.160654481981343 4102 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2966 9084041 48.03 µM -0.992001103278488 0.137525318975184 no 2936 0.160598493611479 3973 17741380
SGTC_3007 9078383 71.4286 µM -0.994174500825839 0.136999427584517 no 2937 0.160068959976628 4070 6496995
SGTC_1070 indatraline 8.81 µM -0.994827519119427 0.136841687254418 no 2938 0.159910079773189 4105 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1970 st070122 35.8 µM -0.995523922575235 0.136673603826673 no 2939 0.159740757595121 4117 102928
SGTC_467 ro 31-8220 72.8 µM -0.996824954898314 0.136359965958911 no 2940 0.15942474153576 4025 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1498 4478-3555 97.6 µM -0.997593638760071 0.136174892097661 no 2941 0.159238223478204 4043 3437919
SGTC_3186 9110464 49.47 µM -0.998895742387662 0.135861780646253 no 2942 0.158922599473661 4098 17018021
SGTC_2561 acetosyringone 100 µM -1.00191541836336 0.135137550203317 no 2943 0.15819222263647 4078 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2025 5147754 141 µM -1.00338505985826 0.134786034996695 no 2944 0.157837554868899 4065 315777 YLR208W SEC13
SGTC_2511 berberine 10.47 µM -1.00392114687689 0.13465796768623 no 2945 0.157708311373419 4072 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3352 9151559 45.5865 µM -1.00430092693634 0.134567291529915 no 2946 0.157616793501579 4104 17159339
SGTC_2148 5546263 113.568 µM -1.00482111804981 0.134443158912173 no 2947 0.157491496577532 4076 792097
SGTC_1484 3473-2379 286 µM -1.00531908529708 0.134324403222561 no 2948 0.157371613990954 4207 671917
SGTC_2506 ethyl hematommate 54.16 µM -1.00931425057483 0.133374239914514 no 2949 0.156411973937045 4179 3940691 An allergen.
SGTC_167 3672-0051 66.205 µM -1.01006780831392 0.133195542140224 no 2950 0.156231402021451 4015 3237971
SGTC_2420 aureobasidin a 50 nM -1.01498055298513 0.132034578562375 no 2951 0.155057548827621 4232 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2331 7980721 200 µM -1.01750428404628 0.131440899928072 no 2952 0.154456797662392 4080 2981221
SGTC_2589 lobaric acid 100 µM -1.01879916492766 0.131137010550039 no 2953 0.154149161132386 4108 73157 A novel microtubule depolymerizer.
SGTC_2744 captopril 92.04 µM -1.01959921868926 0.13094949252082 no 2954 0.153959287853019 4142 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1570 verbenone 133 µM -1.01966561872722 0.130933937892408 no 2955 0.153943536378826 4136 29025 A natural terpanoid with antifungal properties.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.02064674748388 0.130704251084783 no 2956 0.153710916464915 4139 6728940
SGTC_459 nigericin 15.3 µM -1.02072946033659 0.130684900359791 no 2957 0.153691316370805 4184 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.02346650942945 0.130045682907007 no 2958 0.153043663421376 4139 5379071
SGTC_2027 5150920 200 µM -1.02363972047425 0.130005303690061 no 2959 0.153002738396118 4058 786715
SGTC_255 tunicamycin 200.472 nM -1.02471452838118 0.129754936878324 no 2960 0.152748952924195 4039 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2405 ticlatone 3.52 µM -1.02491500769411 0.129708274003587 no 2961 0.152701646321554 3961 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1581 himbacine 57.9 µM -1.02511844947351 0.129660933477521 no 2962 0.152653650608881 4108 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1481 3346-2004 36 µM -1.02563316894761 0.129541212653339 no 2963 0.152532263372758 4172 2770522
SGTC_3274 9138298 49.47 µM -1.02907562867297 0.12874248495541 no 2964 0.151722068748965 4075 17015756
SGTC_2780 5215298 71.43 µM -1.03760829155256 0.12677746746755 no 2965 0.149726228058873 4175 2834131
SGTC_2853 9015042 58.44 µM -1.03830094808195 0.126618874510689 no 2966 0.14956498372445 4047 6457456
SGTC_92 0063-0024 660.874 µM -1.03999483518349 0.126231618745123 no 2967 0.14917115010561 4208 3594437
SGTC_2968 9090663 33.37 µM -1.04038980836292 0.126141438948964 no 2968 0.149079417370447 4090 25236811
SGTC_727 3032-0951 202 µM -1.04362159898281 0.125405247388205 no 2969 0.1483302479189 4164 3652836
SGTC_2030 5175110 200 µM -1.04383909671501 0.125355810033877 no 2970 0.148279919828865 4151 2831986
SGTC_198 3454-2873 16.191 µM -1.04412986397609 0.125289739729286 no 2971 0.148212655314205 4114 710957
SGTC_1963 st076565 50.3 µM -1.04425415262262 0.125261505354995 no 2972 0.148183909284892 4155 4914280
SGTC_1666 st014829 29 µM -1.04572074851508 0.124928677502387 no 2973 0.147844990209219 4118 3858230
SGTC_1337 1486-1011 40.3 µM -1.04617586786716 0.124825518880458 no 2974 0.147739921213893 4102 X1337
SGTC_3074 9116018 49.47 µM -1.04883649846081 0.124223644012078 no 2975 0.147126687986403 4197 17027303
SGTC_2588 indole-3-carbinol 100 µM -1.04908251900117 0.124168093154642 no 2976 0.147070070466773 4195 3712 Induces cell cycle arrest.
SGTC_1004 4084-0029 199 µM -1.04936356383813 0.124104655162176 no 2977 0.147005410569048 4163 716894 YLR208W SEC13
SGTC_3096 9117468 49.47 µM -1.04944979922545 0.124085194488493 no 2978 0.146985574243224 4031 41316311
SGTC_226 1,3-diallylurea 8.28947 mM -1.05058091647892 0.123830133787917 no 2979 0.146725554779283 4089 74537 YKL182W FAS1
SGTC_1160 4092-0570 10.5 µM -1.05100427902788 0.123734762322814 no 2980 0.146628312282316 4138 4994975
SGTC_785 1270-0111 65.3 µM -1.05303037466717 0.12327905297555 no 2981 0.146163535549071 4073 6741994
SGTC_3235 9132602 49.47 µM -1.06251626352422 0.121161133752795 no 2982 0.144000689378089 4170 4912240
SGTC_1419 3993-2473 62.6 µM -1.06431189403325 0.120763120607123 no 2983 0.143593715813825 4224 704026
SGTC_1021 4476-0760 85.3 µM -1.06436782707912 0.120750737482263 no 2984 0.143581051258615 4148 746768
SGTC_2993 9054257 71.4286 µM -1.06457052254223 0.120705869831419 no 2985 0.143535162561988 4086 6470217 YGL055W OLE1
SGTC_451 chloral hydrate 100 µM -1.06602491039358 0.120384278034896 no 2986 0.143206190694918 4178 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_584 0986-0246 15.4 µM -1.07202413070937 0.119064121058271 no 2987 0.141854596904498 4255 53315 YDR232W HEM1
SGTC_1809 st050081 57.6 µM -1.07204222758173 0.119060154279767 no 2988 0.141850532882904 4251 5036894
SGTC_870 0573-2213 57.6 µM -1.07259882831676 0.118938194684932 no 2989 0.14172557534522 4160 3916321
SGTC_287 k060-0039 29.6 µM -1.07534131862519 0.118338562122089 no 2990 0.141110971864044 4215 5861974
SGTC_1707 st032323 6.317 µM -1.07842566877993 0.117666740567413 no 2991 0.140421918466569 4045 3132057 YMR211W DML1
SGTC_1774 st048371 48.465 µM -1.07896332211129 0.117549907792578 no 2992 0.140302039269038 4161 4242727
SGTC_339 3091-4833 71.4 µM -1.08038551445686 0.117241259533599 no 2993 0.139985271814956 4042 3240077
SGTC_1789 tunicamycin 25 nM -1.08065528323668 0.11718277837032 no 2994 0.139925240609244 4078 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_163 TUB2.036 7.546 µM -1.08136855056372 0.117028254022435 no 2995 0.139766602689509 4155 15992207 YJR013W GPI14
SGTC_2596 sinensetin 100 µM -1.08208080437343 0.11687409338377 no 2996 0.139608312236803 4195 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_596 1155-0152 116 µM -1.08312880103996 0.116647526158841 no 2997 0.139375628406791 4171 280313
SGTC_1844 rapamycin 4 nM -1.08365081388982 0.116534788064676 no 2998 0.139259825816279 4070 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2816 7982706 58.44 µM -1.08903762829443 0.115375920013367 no 2999 0.138068646317235 4209 2981853
SGTC_1684 st024538 14.6195 µM -1.09147191157272 0.114854927128424 no 3000 0.137532642419833 4140 6732859
SGTC_2933 9026794 32.47 µM -1.09174634053163 0.114796298124684 no 3001 0.137472305230568 4138 17586027
SGTC_3052 9092717 49.47 µM -1.09343091655672 0.114436871771315 no 3002 0.137102322722859 4195 25237534
SGTC_480 am 92016 50 µM -1.09407232516324 0.114300229655502 no 3003 0.136961629489313 4169 2129 K+ channel blocker.
SGTC_2126 5251174 33.877 µM -1.09737418736283 0.11359865767945 no 3004 0.136238926220043 4211 790722
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.09795933200864 0.11347464844704 no 3005 0.136111123939485 4139 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2515 chrysin 20.77 µM -1.09845845559621 0.113368945904934 no 3006 0.13600217451083 4220 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1016 4226-1401 38 µM -1.09880134555241 0.113296370648215 no 3007 0.135927362592602 4149 2901613
SGTC_2389 9091542 195.52 µM -1.10013327251333 0.113014772632904 no 3008 0.135637029367364 4172 3626624 YOL127W RPL25
SGTC_473 2-arachidonoylglycerol 10 µM -1.10235215931945 0.112546762116137 no 3009 0.13515430073347 4028 5282280 An endocannabinoid.
SGTC_2985 9022375 71.43 µM -1.10513449311097 0.111961867068532 no 3010 0.134550658182349 4269 4939335
SGTC_1167 k781-0610 148 µM -1.10537357409738 0.111911709670061 no 3011 0.13449887473351 4236 4525169
SGTC_904 1141-0088 396 µM -1.10673120586677 0.111627193376596 no 3012 0.134205079613398 4204 1378119
SGTC_3135 9127742 49.47 µM -1.11127251168219 0.110679242358352 no 3013 0.133225533830703 4293 3643468
SGTC_2809 7964133 12.99 µM -1.11172331165012 0.110585458204986 no 3014 0.133128566766554 4207 1253665
SGTC_662 k832-1615 104 µM -1.11201420896527 0.110524970348239 no 3015 0.133066020550923 4230 5878478
SGTC_3200 9114385 49.47 µM -1.11652406321675 0.109590244523515 no 3016 0.132098937929342 4225 17018030 YLR208W SEC13
SGTC_314 1671-0008 2.74 µM -1.11660051721909 0.109574447517886 no 3017 0.132082585195738 4086 3913060
SGTC_1521 st012942 49.4 µM -1.11800748498444 0.109284030237316 no 3018 0.131781898297404 4180 24207259
SGTC_414 piperonyl butoxide 100 µM -1.11897060034998 0.109085549217841 no 3019 0.131576340795398 4203 5794 A potent inhibitor of cytochrome P450.
SGTC_3158 9100007 49.47 µM -1.11987058597894 0.108900312393342 no 3020 0.131384457176148 4239 19297233
SGTC_3078 9116413 49.47 µM -1.12029298582294 0.108813451236524 no 3021 0.131294465045595 4134 17177322
SGTC_817 1391-0715 46 µM -1.12314811142195 0.108227637101554 no 3022 0.130687297865323 4203 1353946
SGTC_3348 9149464 3.537 µM -1.12315202462588 0.10822683575191 no 3023 0.13068646702289 4166 1951442
SGTC_265 mycophenolic acid 32.932 µM -1.12623602595883 0.107596618316515 no 3024 0.130032814164201 4290 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2421 5690543 90.72 µM -1.12635366482275 0.107572631215486 no 3025 0.130007925538898 4234 3397993
SGTC_1629 st005085 44.9 µM -1.12901799716279 0.107030393288683 no 3026 0.129445120849997 4177 24207091
SGTC_1303 1160-0052 261 µM -1.12962490148892 0.106907153874657 no 3027 0.129317156825715 4161 3562476
SGTC_1127 asiatic acid 681.4 nM -1.12977665247494 0.106876354969479 no 3028 0.129285174274746 4166 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_144 4161-2749 112.381 µM -1.13535714440264 0.105748198463975 no 3029 0.128112854058951 4182 797501 YMR168C CEP3
SGTC_3173 9105693 49.47 µM -1.13766740807371 0.105283682259005 no 3030 0.127629693801319 4237 17096658
SGTC_2629 bisabolol 100 µM -1.13991744245087 0.104832696930054 no 3031 0.127160348752687 4274 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_512 prima-1 270 µM -1.14022229069221 0.104771702473273 no 3032 0.127096851546933 4241 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1265 0819-1001 68.8 µM -1.14171619491291 0.104473171586199 no 3033 0.126786003454936 4182 3106768
SGTC_883 0850-0245 24.6 µM -1.142585966564 0.104299646902113 no 3034 0.126605267412468 4301 6823229 YPR165W RHO1
SGTC_1662 st014054 52 µM -1.14260164083937 0.104296521707005 no 3035 0.126602011990109 4271 2838777
SGTC_2252 omeprazole 400 µM -1.14310343757316 0.10419650747733 no 3036 0.126497823607509 4209 4594 A proton pump inhibitor.
SGTC_761 k216-0224 480 µM -1.14720744901258 0.103381136330965 no 3037 0.125647946835476 4281 1340404
SGTC_1695 st026914 34.495 µM -1.14731858151557 0.103359121493614 no 3038 0.125624988559882 4212 3289191
SGTC_42 0133-0086 60.653 µM -1.14866227428878 0.103093211435209 no 3039 0.125347633807025 4122 162923 Model of phenazepam hydroxylation.
SGTC_680 0417-1641 114 µM -1.15037535525712 0.102754922282279 no 3040 0.124994653058913 4237 2835990
SGTC_3140 9094243 49.47 µM -1.15403783535764 0.10203438475885 no 3041 0.12424232878166 4219 19291112
SGTC_2730 imipramine 71.33 µM -1.15437391698442 0.101968450407312 no 3042 0.124173451945021 4216 3696 A tricyclic antidepressant.
SGTC_138 0850-0259 40.9225 µM -1.15598452565758 0.101652902611467 no 3043 0.123843743280203 4190 6813004
SGTC_348 k064-0012 10.7 µM -1.15624602146919 0.101601737945623 no 3044 0.12379027019369 4172 5066323
SGTC_717 1532-0246 73.2 µM -1.15665657656902 0.101521445952108 no 3045 0.123706348695906 4227 9561992
SGTC_1284 0929-0043 16 µM -1.15946347733363 0.100973739920795 no 3046 0.123133657704826 4256 1239883
SGTC_2923 7992654 58.14 µM -1.16078154598547 0.100717291844854 no 3047 0.122865374764146 4242 2985126
SGTC_704 1310-0270 142 µM -1.16150770167406 0.100576211536662 no 3048 0.122717746483863 4270 5718033
SGTC_295 k015-0027 31 µM -1.16203054111998 0.100474721591487 no 3049 0.122611529698008 4293 3887424
SGTC_1886 st057356 49.9 µM -1.16464785458274 0.0999677901335927 no 3050 0.122080782300147 4225 24207747
SGTC_975 1335-0046 28.5 µM -1.17033475862942 0.0988727717106959 no 3051 0.120933139641734 4272 16486740
SGTC_370 0180-0345 38.7 µM -1.17449334633186 0.098077605196844 no 3052 0.120098737740314 4110 3989527
SGTC_3122 9126309 49.47 µM -1.17544251455481 0.0978967726537804 no 3053 0.119908861459098 4319 17591206
SGTC_3231 9132313 49.47 µM -1.18160885217213 0.0967279289570058 no 3054 0.118680469734982 4205 4905967
SGTC_277 nystatin 15.5 µM -1.18492975421783 0.0961027063129712 no 3055 0.118022610977344 4279 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1613 st002381 52.1 µM -1.1906015456896 0.095041763576092 no 3056 0.116905022272986 4260 551167
SGTC_1237 0330-0133 46.1 µM -1.19217957982985 0.0947481225988121 no 3057 0.116595419248678 4218 X1237 YHR072W ERG7
SGTC_2423 st077119 87.2 µM -1.19404757707257 0.0944013900303768 no 3058 0.116229678894966 4205 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1399 3562-5772 25 µM -1.19606713016069 0.0940275796819171 no 3059 0.115835181702823 4265 23847490
SGTC_2088 5278280 127.392 µM -1.19650918944961 0.0939459023645456 no 3060 0.115748957337286 4332 791502
SGTC_1171 0368-0077 21.4 µM -1.19689835694379 0.093874040975212 no 3061 0.11567308733827 4238 3239779
SGTC_3001 9076041 71.4286 µM -1.19711660710418 0.0938337579399773 no 3062 0.115630553925867 4265 16004211
SGTC_1388 3346-4487 254 µM -1.19988099831122 0.0933246304821378 no 3063 0.11509278034018 4349 3345614
SGTC_3272 9137413 49.47 µM -1.20173340022555 0.0929846110584915 no 3064 0.114733418075644 4188 17614870
SGTC_2192 5915882 198.485 µM -1.20634565157383 0.0921419850374692 no 3065 0.113842121121241 4257 2876149
SGTC_3043 9092303 49.47 µM -1.2086693258808 0.0917196134987235 no 3066 0.113394955355238 4301 25236084
SGTC_3115 9123671 49.47 µM -1.21160120066527 0.0911887389135825 no 3067 0.112832537374742 4419 3286988
SGTC_2787 5284540 71.43 µM -1.21430536697386 0.0907011185861241 no 3068 0.112315568475784 4325 736958
SGTC_2156 5649887 115 µM -1.2145528483512 0.0906565891233161 no 3069 0.11226834090847 4324 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1723 st034307 2.5525 µM -1.21719017830888 0.0901830602965132 no 3070 0.111765933107901 4320 867466
SGTC_3154 9100113 49.47 µM -1.21863251091363 0.0899248699579015 no 3071 0.111491851902259 4301 25237525
SGTC_1250 0485-0349 40.2 µM -1.22051468731963 0.0895887703737514 no 3072 0.111134912614179 4328 6842794 YDL195W SEC31
SGTC_3303 9125618 40.5795 µM -1.22097900167737 0.0895060017443761 no 3073 0.111046985180239 4311 22695467
SGTC_1730 st033808 45.1 µM -1.22319538625601 0.0891116927889737 no 3074 0.110627953891426 4239 1045166
SGTC_199 4063-0024 41.6 µM -1.22436045641529 0.0889049384730759 no 3075 0.11040813985909 4334 306215
SGTC_3098 9119039 49.47 µM -1.22576005741439 0.0886570365839541 no 3076 0.110144491124741 4305 17161528
SGTC_2378 9074213 121.43 µM -1.22837211145638 0.0881957587058015 no 3077 0.109653656036193 4269 657714
SGTC_31 0508-1974 57.237 µM -1.2308423028208 0.0877611812972841 no 3078 0.109190925191023 4237 6810525
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.23125828149468 0.0876881561529745 no 3079 0.1091131398454 4324 16486 A toxic proline analog.
SGTC_1747 st037496 66.6 µM -1.23258485435474 0.0874555788125438 no 3080 0.10886534523266 4276 723305
SGTC_2611 pyromycin 23.93 µM -1.23274492803506 0.087427545542112 no 3081 0.108835471956357 4283 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1691 st019933 84.6 µM -1.23578087580462 0.086897137386733 no 3082 0.108270012754926 4303 6176082
SGTC_1822 st052468 42 µM -1.23611164109923 0.0868394951726118 no 3083 0.108208534167858 4313 2873678
SGTC_1766 st045414 44.774 µM -1.24122605283164 0.0859518432145895 no 3084 0.107261126526238 4326 253960
SGTC_716 1683-5115 658 µM -1.24426196529861 0.085428154684818 no 3085 0.106701582257694 4306 723597
SGTC_2762 leflunomide 42.06 µM -1.24803723936615 0.0847802661178273 no 3086 0.106008710007419 4300 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_957 1187-1561 14.1 µM -1.24850636779814 0.0847000153318807 no 3087 0.105922838953568 4279 1538454
SGTC_2972 9093619 59.92 µM -1.24881530858337 0.084647197936713 no 3088 0.105866316715797 4278 25236256
SGTC_232 clozapine 119 µM -1.25066879964121 0.0843308383966529 no 3089 0.105527669079986 4327 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2570 licareol 100 µM -1.25391244909215 0.083779338685706 no 3090 0.104936914800255 4312 443158
SGTC_1272 0839-0021 27 µM -1.26042378371713 0.082680437102432 no 3091 0.10375826316574 4349 5027250
SGTC_1501 4491-0275 38.4 µM -1.26070983610573 0.0826324106941332 no 3092 0.10370670440726 4318 5104718
SGTC_2377 9073351 62.6 µM -1.26189067900099 0.0824343767724573 no 3093 0.103494063234168 4318 7337946 YHR072W ERG7
SGTC_49 0717-0965 32.132 µM -1.26357146151081 0.0821531167655039 no 3094 0.103191941085168 4406 5889349 YGL099W LSG1
SGTC_648 0375-0473 33.3 µM -1.26502203490037 0.0819109613186888 no 3095 0.102931714538797 4312 1713139
SGTC_580 1123-0028 41 µM -1.26537741944519 0.0818517163412102 no 3096 0.102868032871527 4386 1677248 YPR107C YTH1
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.26895357702113 0.0812573434646567 no 3097 0.102228810885652 4372 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2961 9083290 32.55 µM -1.27129400504654 0.0808701207586759 no 3098 0.101812037142182 4285 17741490
SGTC_3281 9140613 49.47 µM -1.273133008328 0.0805668371716293 no 3099 0.101485423823457 4348 16013766
SGTC_2931 9014674 55.67 µM -1.276377994196 0.080033779276226 no 3100 0.100910965689281 4311 2996810
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.27835706185473 0.0797099869405003 no 3101 0.100561778267781 4425 5282309
SGTC_2295 7971645 200 µM -1.29306918935232 0.0773339509473555 no 3102 0.0979935651063363 4407 2978226 YKL099C UTP11
SGTC_786 4544-0069 423 µM -1.29536482161604 0.0769681056095442 no 3103 0.0975972037278316 4346 748821 YLR208W SEC13
SGTC_806 3966-4455 5.86 µM -1.29742632489175 0.0766406948704523 no 3104 0.0972422698234565 4337 714982
SGTC_2600 tangeritin 87.95 µM -1.29943069300949 0.0763233750655633 no 3105 0.0968980820291804 4277 68077 A bioactive flavone.
SGTC_2556 citropten 84.59 µM -1.29966147871678 0.0762869027032401 no 3106 0.0968585092669319 4381 2775 A potential DNA crosslinker.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.30021030364571 0.0762002220909781 no 3107 0.0967644500722565 4367 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1317 1273-0028 910 nM -1.30671608863343 0.075178411292066 no 3108 0.0956545762592377 4382 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3356 9151811 4.48 µM -1.30690413050072 0.0751490331971002 no 3109 0.0956226365585091 4371 1859254 YPR165W RHO1
SGTC_1353 1498-1206 8.11 µM -1.31004172693247 0.0746601319516255 no 3110 0.0950908600126712 4410 6756808
SGTC_2772 vinpocetine 57.06 µM -1.31240250581869 0.074293877756231 no 3111 0.0946921809277989 4383 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_318 1488-0629 67.2 µM -1.31334698031798 0.074147735652276 no 3112 0.0945330272701911 4415 3662576
SGTC_1677 st019204 53.9 µM -1.31509672372775 0.0738775716148289 no 3113 0.094238698780769 4385 3945625
SGTC_272 doxorubicin 8.13 µM -1.31835390686744 0.0733766601568305 no 3114 0.0936926015455098 4409 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2063 5246145 200 µM -1.31899408759627 0.0732785150451072 no 3115 0.0935855445405513 4425 711240
SGTC_1748 st037455 53.6035 µM -1.32145410302024 0.0729023081210761 no 3116 0.0931749982363534 4408 580690
SGTC_1937 st074714 47.2 µM -1.32438962893788 0.0724553188839651 no 3117 0.092686838583962 4323 17250970
SGTC_2677 mitomycin C 100 µM -1.32490991069117 0.0723763156705165 no 3118 0.0926005166722884 4454 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2151 5563267 85.4165 µM -1.32608386806533 0.0721982962888133 no 3119 0.0924059594737127 4446 5310824
SGTC_2643 anethole 100 µM -1.32785151786665 0.0719308824871106 no 3120 0.0921135818834758 4371 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2009 4012297 12.05 µM -1.34268782756627 0.0697162668479695 no 3121 0.0896865389117513 4369 45595307
SGTC_1402 3909-7673 35.9 µM -1.3455073122452 0.0693014011156639 no 3122 0.0892307307584628 4408 5328014
SGTC_1188 1403-0014 4.57 µM -1.34627752980084 0.0691884008366939 no 3123 0.089106514843995 4414 9614867
SGTC_889 0919-1524 82.7 µM -1.34817169884981 0.0689111071063593 no 3124 0.0888015824683955 4414 3905452
SGTC_2262 9014885 67.46 µM -1.34886017101461 0.0688105319195915 no 3125 0.0886909416860781 4422 6457424
SGTC_2884 9058502 51.95 µM -1.35038954474217 0.06858751893153 no 3126 0.0884455313819387 4409 6471554
SGTC_2401 5128683 200 µM -1.35497577029191 0.0679220982916417 no 3127 0.0877126384283562 4405 708373
SGTC_2755 lomerizine 42.69 µM -1.35499194112484 0.0679197608987478 no 3128 0.0877100623196022 4335 3949 A calcium channel blocker.
SGTC_2201 6605497 169.863 µM -1.35593134708986 0.0677840822189532 no 3129 0.0875605062923799 4342 670741
SGTC_2504 purpurogallin 52.29 µM -1.35857533251743 0.0674033343431516 no 3130 0.0871405981044007 4317 5281571 An antioxidant.
SGTC_38 0929-0051 58.268 µM -1.35947856763332 0.067273643204547 no 3131 0.0869974947307767 4377 1379719
SGTC_3256 9138902 49.47 µM -1.36235146724174 0.0668624199495256 no 3132 0.0865434961678249 4512 17228773
SGTC_3013 9080133 71.4286 µM -1.36323224477539 0.0667367368320327 no 3133 0.086404664003673 4473 17050193
SGTC_1588 farnesol 29.9 µM -1.36589516057091 0.0663578621044971 no 3134 0.0859859359647821 4421 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2387 9077560 195.08 µM -1.36807837087189 0.0660484832784323 no 3135 0.0856437730720672 4427 5303272
SGTC_623 k072-0108 16.9 µM -1.36829252904995 0.0660181955932011 no 3136 0.0856102641863979 4386 5382803
SGTC_3 0833-0587 95.581 µM -1.36848144155162 0.0659914872548415 no 3137 0.0855807135892689 4285 5382644
SGTC_1075 aripiprazole 15.2 µM -1.37268595684416 0.065399219603825 no 3138 0.0849249983736988 4469 60795 An atypical antipschotic. YIL048W NEO1
SGTC_594 1487-1584 10.8 µM -1.37448661491995 0.0651468349706543 no 3139 0.0846453314270462 4372 5013332
SGTC_136 0097-0015 404.482 µM -1.37599551333838 0.0649359266732396 no 3140 0.0844115111675304 4408 4861337
SGTC_1356 1502-0781 85.8 µM -1.38033394860696 0.0643324685202301 no 3141 0.0837419234445556 4426 567702
SGTC_469 w7 172 µM -1.38092874752562 0.064250075294571 no 3142 0.0836504349321314 4521 45115570 A P450 inhibitor.
SGTC_1364 1653-0028 37.6 µM -1.38102902324582 0.0642361929011904 no 3143 0.0836350185037302 4416 5718652
SGTC_1965 Pectolinarigenin 58.4 µM -1.38272248596847 0.0640020981473147 no 3144 0.0833749872228391 4402 5320438 An anti-inflammatory.
SGTC_1583 clindamycin 39.6 µM -1.38382601130284 0.06384991034283 no 3145 0.0832058681781649 4376 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1140 3229-1848 2.98 µM -1.38667207689942 0.0634587068214695 no 3146 0.0827708894422596 4419 2849525
SGTC_834 0312-0008 75.7 µM -1.38726784574271 0.0633770525417291 no 3147 0.0826800520155911 4443 6385573 YIL048W NEO1
SGTC_815 1582-0027 36.9 µM -1.39010383999413 0.0629894805368887 no 3148 0.082248673706038 4448 3128206
SGTC_751 0833-0568 350 µM -1.39391656656569 0.0624713390947545 no 3149 0.0816714004820746 4442 6954252
SGTC_1048 3161-0300 24.5 µM -1.39458006593769 0.0623815113670002 no 3150 0.0815712548739982 4435 2165101
SGTC_1500 4488-1866 171 µM -1.39475798278157 0.0623574412646871 no 3151 0.0815444166565418 4478 2900003
SGTC_1106 tegaserod maleate 11.7 µM -1.39619693040804 0.06216303428508 no 3152 0.0813276004125246 4463 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2127 5253358 187.912 µM -1.39646204834264 0.062127267538635 no 3153 0.0812877007362144 4355 20612
SGTC_988 1497-1057 103 µM -1.39751309964062 0.0619856294239137 no 3154 0.0811296651008181 4419 3533044
SGTC_2701 st077767 14.721 µM -1.39953451221919 0.0617139353123019 no 3155 0.0808263782518368 4405 5721188
SGTC_1052 3253-3998 198 µM -1.4055628838982 0.0609091926350063 no 3156 0.0799269819858554 4395 5450317
SGTC_973 1325-0077 65.9 µM -1.40641666524007 0.0607958854952464 no 3157 0.0798002172373906 4443 2835149
SGTC_2235 salicylic acid 500 µM -1.40995965873757 0.060327447672619 no 3158 0.0792757975464206 4487 338 A COX inhibitor and kinase inhibitor.
SGTC_2888 9058547 12.99 µM -1.41755034707991 0.0593333551907394 no 3159 0.0781610426707408 4373 16476514
SGTC_3148 9097893 49.47 µM -1.41791527500117 0.0592858889831476 no 3160 0.0781077511001317 4413 17174100
SGTC_945 3381-0768 11.3 µM -1.41857165303184 0.0592005887789648 no 3161 0.0780119675353586 4455 1126236 YIL048W NEO1
SGTC_1020 4335-0961 93.3 µM -1.41943405687326 0.0590886606435713 no 3162 0.0778862546522196 4405 669075
SGTC_1027 k015-0025 8.67 µM -1.41983450095609 0.0590367449830898 no 3163 0.0778279340817707 4411 3598955
SGTC_1355 1499-0035 1.68 µM -1.42092116178748 0.0588960448901907 no 3164 0.0776698400900091 4443 1548538
SGTC_1850 st056238 17 µM -1.42182894916473 0.0587787070377482 no 3165 0.0775379566947649 4458 5393177
SGTC_1953 st076800 12.1 µM -1.42260396061623 0.058678676647711 no 3166 0.0774254976087678 4434 297591
SGTC_2960 9079389 5.97 µM -1.42842486033 0.0579316406936036 no 3167 0.0765848039162781 4430 16457355
SGTC_665 3914-0008 307 µM -1.42862821408963 0.0579056786815157 no 3168 0.0765555602048855 4413 1069549
SGTC_1335 1486-0900 202 µM -1.42984117742404 0.057751010543489 no 3169 0.0763813038874083 4444 X1335
SGTC_730 1436-0052 41.2 µM -1.43780668685435 0.0567433640013083 no 3170 0.0752444557700863 4491 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_448 monastrol 171 µM -1.43962436044925 0.0565153781895852 no 3171 0.0749868518651717 4373 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1403 3909-7815 62.9 µM -1.44062879589014 0.0563897046100127 no 3172 0.0748447903536335 4442 6615483
SGTC_866 0495-0101 262 µM -1.44330826096701 0.0560555310523266 no 3173 0.0744668268549725 4468 635694
SGTC_1409 3909-8004 61.9 µM -1.44486464701642 0.0558621422727283 no 3174 0.0742479541049654 4507 2119279
SGTC_2939 9044578 71.43 µM -1.44515988485732 0.0558255169539172 no 3175 0.0742064906465917 4395 2653634
SGTC_407 eburnamonine 100 µM -1.44815856617266 0.0554545923170546 no 3176 0.0737863547054391 4317 3195
SGTC_671 0560-0003 407 µM -1.45303465912982 0.0548555971310191 no 3177 0.0731070655790017 4411 3238678
SGTC_723 4182-0001 115 µM -1.45574658034043 0.0545246755990626 no 3178 0.0727313440075337 4476 744821 YLR208W SEC13
SGTC_605 1315-0399 119 µM -1.46099669134791 0.0538885204251226 no 3179 0.0720081747158276 4551 24020461
SGTC_1943 st076331 65.2 µM -1.4643694279446 0.0534829563663528 no 3180 0.0715465183207929 4466 24208415
SGTC_1359 1582-0056 520 nM -1.46566183008223 0.0533281903082963 no 3181 0.0713702188587737 4514 3661189
SGTC_1072 oxiconazole 14.9 nM -1.46691464829615 0.053178503478637 no 3182 0.0711996375946657 4463 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1773 st048542 73.5835 µM -1.46725829998975 0.053137502213654 no 3183 0.0711529014081258 4461 3237138
SGTC_2776 terbinafine 19.92 µM -1.47008584396026 0.0528010972531144 no 3184 0.0707692529024439 4488 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3171 9103192 49.47 µM -1.48187652135882 0.0514164862299558 no 3185 0.0691865766642759 4566 13018434
SGTC_2335 9018011 154.17 µM -1.48250061538689 0.0513440096512065 no 3186 0.0691035699870435 4457 6458208
SGTC_1667 st014849 34.6 µM -1.48342818150433 0.0512364407708831 no 3187 0.0689803422845351 4565 5348460
SGTC_8 0354-0001 70 µM -1.48915526659361 0.0505762424247351 no 3188 0.0682232436477653 4485 4993152
SGTC_2106 5357045 167.29 µM -1.49483327403715 0.0499284088284167 no 3189 0.0674789800200341 4523 668842
SGTC_2175 5807670 165.306 µM -1.49622971680427 0.0497700996195082 no 3190 0.0672969015511577 4451 241186
SGTC_1418 3966-3099 2.4 µM -1.50382185760899 0.0489164032036716 no 3191 0.0663136208111313 4506 740335
SGTC_2327 6189656 200 µM -1.50535839194976 0.0487450598486159 no 3192 0.0661159801378364 4554 5349088
SGTC_1482 3346-2049 8.48 µM -1.50582583161642 0.0486930295813047 no 3193 0.0660559451237614 4536 3826804
SGTC_2298 7976326 193.81 µM -1.50676905916441 0.0485881749884482 no 3194 0.0659349315072302 4449 2235818
SGTC_1721 st082152 9.2685 µM -1.50701901811223 0.0485604183953418 no 3195 0.0659028912438061 4437 5296051
SGTC_2312 7706453 155.7 µM -1.50912827816371 0.0483267010027792 no 3196 0.0656330021482611 4502 976098
SGTC_2193 5925765 200 µM -1.50940950729465 0.0482956073931432 no 3197 0.0655970824829626 4513 877370
SGTC_2140 5586273 200 µM -1.51265613489624 0.0479378072640991 no 3198 0.0651835136302135 4474 854421
SGTC_2390 9097792 176.6 µM -1.51567508483181 0.0476070056212056 no 3199 0.0648007653439474 4524 4497149
SGTC_66 0109-0187 42.4 µM -1.52412386637419 0.0466909409655197 no 3200 0.0637388859087971 4370 759417
SGTC_1711 st032263 62.8 µM -1.52618982419272 0.0464691038383612 no 3201 0.0634812984691861 4503 3958979
SGTC_913 3487-1245 167 µM -1.53001478821241 0.046060622884549 no 3202 0.0630065342542644 4447 4016153
SGTC_770 0389-1121 67.2 µM -1.53214490108679 0.0458343942984355 no 3203 0.0627433408273132 4537 6753108
SGTC_2028 5153890 36.43 µM -1.53860134107073 0.045154139037757 no 3204 0.0619508254788303 4497 2830968 YPR165W RHO1
SGTC_161 4065-0411 162.148 µM -1.53931968084248 0.0450789590743106 no 3205 0.0618631357788955 4499 1906281 YLR208W SEC13
SGTC_10 0279-0212 42.575 µM -1.54193447151893 0.0448061507830905 no 3206 0.0615447590733859 4533 39851 YBR002C RER2
SGTC_2004 4023728 41.89 µM -1.54252892516449 0.0447443156350369 no 3207 0.0614725572772829 4465 360084 YDR527W RBA50
SGTC_463 ikarugamyin 104 µM -1.54395258321509 0.0445965058739859 no 3208 0.0612999100263556 4669 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_3198 9112019 49.47 µM -1.54726517800234 0.0442541013891094 no 3209 0.0608996574531602 4562 45595555
SGTC_97 0535-0701 19.132 µM -1.54926796390729 0.0440481144933229 no 3210 0.0606586587733067 4411 2832013 YGL099W LSG1
SGTC_380 3970-0968 6 µM -1.55820726637541 0.0431381136686277 no 3211 0.0595920615143561 4426 2891601
SGTC_148 3253-0744 288.01 µM -1.55823338977517 0.0431354767902538 no 3212 0.0595889662676116 4411 6893655
SGTC_2341 7987486 176.74 µM -1.56333099353739 0.0426234143329991 no 3213 0.058987380957384 4533 1258686
SGTC_2502 avocadyne acetate 18.59 µM -1.56362276780473 0.0425942544868882 no 3214 0.0589530923915858 4470 3952079
SGTC_1271 0832-2808 169 µM -1.5655079788246 0.0424062355756182 no 3215 0.058731924010228 4561 3663794
SGTC_946 3434-1334 87.4 µM -1.56729732205719 0.0422283994349256 no 3216 0.0585226055236268 4504 4047976
SGTC_2532 xanthone 78.9 µM -1.56973829856025 0.041986773504303 no 3217 0.0582380036659116 4549 7020 An insecticide.
SGTC_2043 5101342 149 µM -1.57469272271519 0.0414997891867412 no 3218 0.0576636941994134 4559 678451
SGTC_1838 st055369 84.5 µM -1.58097930493387 0.0408884621101992 no 3219 0.0569413848485166 4513 676036
SGTC_234 nsc-17383 10.7 µM -1.58399344078011 0.0405979599082999 no 3220 0.0565976058770715 4539 408974
SGTC_545 4218-0007 221 µM -1.5879130568504 0.0402226957518759 no 3221 0.0561530002891884 4545 2840508
SGTC_854 0422-0053 192 µM -1.59415155942918 0.0396312366256876 no 3222 0.0554510465462842 4563 3596728
SGTC_495 decylubiquinone 155 µM -1.60161662529797 0.0389328055341099 no 3223 0.0546202060615461 4541 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2711 st079103 59.1 µM -1.60234373010994 0.0388653166866107 no 3224 0.0545398102649164 4478 54693780
SGTC_56 0957-0365 83.25 µM -1.61280097006304 0.0379051878451808 no 3225 0.0533938776549179 4505 6752360
SGTC_440 fluspirilene 35.1 µM -1.61682355191857 0.0375410483110656 no 3226 0.0529581870108202 4568 3396 An atypical antipsychotic.
SGTC_1977 st070720 65.3 µM -1.62010999735237 0.0372456712846669 no 3227 0.0526043251229584 4576 682188
SGTC_2495 cafestol 54.53 µM -1.62926035669723 0.0364332527565 no 3228 0.0516289572993926 4558 16667697 An anti-infammatory.
SGTC_485 niflumic acid 177 µM -1.6328110239054 0.036121936240022 no 3229 0.0512543739132141 4600 4488 A COX2 inhibitor.
SGTC_1088 bifonazole 369 nM -1.6344430877684 0.0359795721505523 no 3230 0.0510829235770334 4560 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1868 st057644 42.7 µM -1.63608818244113 0.0358365368251484 no 3231 0.050910566557542 4588 688665
SGTC_629 3448-6466 76.7 µM -1.63770089605111 0.0356967694883468 no 3232 0.0507420518057509 4584 573744
SGTC_3248 9135562 49.47 µM -1.64460914588698 0.0351031065274201 no 3233 0.0500252197814401 4559 17650701
SGTC_2089 5281248 129.67 µM -1.64658221770226 0.0349350450791033 no 3234 0.0498219739834212 4547 2737878
SGTC_2525 harmine 47.85 µM -1.64855328766771 0.0347678141576681 no 3235 0.0496195926314877 4585 5280953 A monoamine oxidase inhibitor
SGTC_2952 9073731 13.78 µM -1.65424942916008 0.0342882293228429 no 3236 0.0490384217255279 4551 16457353
SGTC_1357 1503-1303 39.5 µM -1.66003467936287 0.0338067209289835 no 3237 0.0484537380959571 4551 292895
SGTC_2951 9072950 58.06 µM -1.66023648027162 0.0337900258926496 no 3238 0.0484334442434258 4497 16488155
SGTC_951 1171-0579 82.7 µM -1.66146475501778 0.033688556666786 no 3239 0.0483100709076378 4508 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_801 0866-0028 10.1 µM -1.66176176068026 0.0336640583616511 no 3240 0.0482802761229375 4617 6849771
SGTC_2053 5265679 138 µM -1.66863837286704 0.0331009329764657 no 3241 0.047594534630379 4497 764595
SGTC_164 4100-3994 89.624 µM -1.66893262550601 0.0330770108527286 no 3242 0.04756536647145 4545 4615967
SGTC_2813 7971799 71.43 µM -1.69084264532042 0.0313353857570446 no 3243 0.045433429945619 4570 2234054
SGTC_2999 9069765 71.4286 µM -1.69987792310585 0.0306395995548044 no 3244 0.0445769451692138 4545 2097066
SGTC_2129 girgensonine 121.053 µM -1.70124800346764 0.0305352184231089 no 3245 0.0444482136364954 4566 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_530 4358-1714 28 µM -1.70248371090782 0.0304413274413595 no 3246 0.044332364731301 4578 1564641
SGTC_2382 9035899 200 µM -1.70263763548811 0.0304296487813019 no 3247 0.0443179511949441 4583 6462679
SGTC_15 0266-0086 27.098 µM -1.70840461640349 0.0299947605332409 no 3248 0.0437806456376284 4656 1712902 YIL048W NEO1
SGTC_3004 9076122 71.4286 µM -1.71790034141274 0.0292899243265964 no 3249 0.0429073972777691 4585 44782551
SGTC_1637 st007924 17.4 µM -1.72143254078066 0.0290312754580186 no 3250 0.0425861818038437 4519 683336
SGTC_2108 5365811 200 µM -1.72251878473479 0.0289521167700408 no 3251 0.042487791468361 4599 780283
SGTC_1362 1611-0397 101 µM -1.72463362976556 0.0287985146307052 no 3252 0.0422967594250034 4601 27816
SGTC_2016 5121758 140 µM -1.72776427173697 0.0285723789733095 no 3253 0.0420152476625342 4521 2795203
SGTC_867 0518-0118 155 µM -1.73686606262546 0.0279233043533419 no 3254 0.0412054074754433 4580 6848158
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.74006171913418 0.0276983460338069 no 3255 0.0409240905722982 4594 689007
SGTC_1151 3909-8316 15.3 µM -1.75621512478142 0.0265842170759736 no 3256 0.0395258415553154 4639 800431
SGTC_1835 st008666 49.2 µM -1.75848456710353 0.0264307308922887 no 3257 0.0393325476063966 4581 690455
SGTC_900 1112-0045 141 µM -1.76594264563122 0.0259315352271548 no 3258 0.0387027358098831 4537 56211 YIL048W NEO1
SGTC_516 3992-2719 87.3 µM -1.76676853720007 0.0258767436822709 no 3259 0.0386334999467528 4507 5350887 YDR037W KRS1
SGTC_2603 homopterocarpin 100 µM -1.76917770258867 0.0257174672635177 no 3260 0.0384321119943465 4595 101795 A weak amylase inhibitor.
SGTC_556 4058-0063 51.5 µM -1.79206539788469 0.0242448302388809 no 3261 0.0365612454187907 4636 6615692
SGTC_744 1594-0068 283 µM -1.80083003531071 0.0236999677458045 no 3262 0.035864836630948 4623 668392
SGTC_1705 st027868 56.3335 µM -1.80231185355429 0.0236088742759002 no 3263 0.0357481773107593 4557 292948
SGTC_1839 st053978 48 µM -1.81544154764714 0.0228145285606949 no 3264 0.0347280405300709 4649 3788398
SGTC_22 0964-0034 14.468 µM -1.81681729926137 0.0227326145815209 no 3265 0.0346225465283089 4638 138402
SGTC_365 0121-0052 13.6 µM -1.81757638123923 0.0226875240934985 no 3266 0.034564452137048 4605 3101739
SGTC_143 4032-1194 15.74 µM -1.82856196599767 0.0220433605663493 no 3267 0.0337326274044693 4644 1806963
SGTC_1464 k208-0027 110 µM -1.82987154466316 0.0219676106946864 no 3268 0.0336345746739478 4625 X1464
SGTC_2664 lyso-paf C-16 73.48 µM -1.83518034930503 0.0216627813710041 no 3269 0.0332394858789223 4639 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1515 3460-0031 42.1 µM -1.8375810966489 0.0215261094534151 no 3270 0.0330620782065779 4623 2876596
SGTC_3085 9117376 49.47 µM -1.84930966471751 0.0208688474876731 no 3271 0.03220655549825 4677 16480349
SGTC_2400 5203494 178.7 µM -1.85088565477602 0.0207818383097883 no 3272 0.0320930024623329 4551 6777674
SGTC_3120 9124077 49.47 µM -1.85800997491283 0.0203923332847873 no 3273 0.0315837989028536 4719 18774327 YGL155W CDC43
SGTC_1771 st048882 4.1505 µM -1.86020073116566 0.0202738098712946 no 3274 0.0314285658296991 4657 4580403
SGTC_462 ag-879 158 µM -1.86958412472805 0.0197727396128953 no 3275 0.0307707957569496 4639 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2836 9010338 19.48 µM -1.87847394293176 0.0193077622648907 no 3276 0.0301581792086017 4594 2994051
SGTC_1397 3532-0190 20.1 µM -1.87927164141889 0.019266497126715 no 3277 0.0301037059049908 4655 5322280
SGTC_342 k048-0088 23.3 µM -1.88403630286022 0.0190215778434282 no 3278 0.0297800325650974 4655 6820570
SGTC_3112 9123419 49.47 µM -1.89543140240604 0.0184465493331976 no 3279 0.029017635854477 4689 17015854
SGTC_3255 9139072 49.47 µM -1.90557918039774 0.0179469921909547 no 3280 0.0283524127127501 4671 17646060
SGTC_264 promethazine 12.5 mM -1.91075239082676 0.0176967949225792 no 3281 0.028018204287294 4537 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1837 st055472 66.5 µM -1.91520524583469 0.0174838263706662 no 3282 0.027733166879086 4680 676091
SGTC_1696 st025591 34.7925 µM -1.92924272694611 0.0168267151762665 no 3283 0.0268503680750009 4650 2787147
SGTC_2467 5474540 200 µM -1.93143414278087 0.0167260627478102 no 3284 0.0267146931333952 4654 5413519
SGTC_3106 9121286 49.47 µM -1.93291005295341 0.0166585643672783 no 3285 0.0266236396237676 4613 15943471
SGTC_3291 9121177 71.43 µM -1.95548000556697 0.0156550439486969 no 3286 0.0252632205383822 4651 17015612
SGTC_1164 k060-0068 93.7 µM -1.95612301919684 0.0156272307537509 no 3287 0.0252253320375147 4670 5963676
SGTC_517 1365-0151 113 µM -1.9606152278023 0.0154341030506156 no 3288 0.0249619623258291 4651 768657
SGTC_2278 7948257 134.34 µM -1.96846372808402 0.0151015983093054 no 3289 0.0245073527974078 4679 1247028
SGTC_2069 5228469 200 µM -1.97951929353764 0.0146436780530721 no 3290 0.0238787847968356 4659 2835210
SGTC_2351 9026858 72.31 µM -1.98566584147237 0.0143942943739518 no 3291 0.0235352201385857 4603 1409300
SGTC_11 0438-0307 1.3 µM -1.98581601044632 0.014388247618314 no 3292 0.0235268786715026 4672 4011476
SGTC_3167 9103034 49.47 µM -1.98582055624478 0.0143880646097382 no 3293 0.0235266262038811 4740 5127859
SGTC_2775 cyproheptadine 69.59 µM -1.98709653203038 0.0143367744783745 no 3294 0.0234558502449594 4675 2913 A selective serotonin reuptake inhibitor.
SGTC_2020 4017018 200 µM -2.01300295687759 0.0133289577791147 no 3295 0.0220571591432972 4678 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2469 5655019 90.81 µM -2.01372321871603 0.0133018351860361 no 3296 0.0220193004405185 4724 2788239
SGTC_2489 cantharidin 73.42 µM -2.0147313171057 0.0132639537166532 no 3297 0.0219664044836882 4648 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_7 0192-1582 4.227 µM -2.03648163823604 0.012469040005246 no 3298 0.0208510075324118 4714 252616
SGTC_1400 3771-8998 51.5 µM -2.06495728891244 0.0114909236252947 no 3299 0.0194635208625726 4691 670767
SGTC_615 k087-0205 167 µM -2.07639874478028 0.0111171003448653 no 3300 0.0189285436286723 4714 9642773
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.10658035757838 0.010181305160801 no 3301 0.0175769854264756 4691 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2476 5806916 10.51 µM -2.13188377861886 0.00945047233595116 no 3302 0.0165082010311957 4669 2870194
SGTC_139 0099-0334 718.624 µM -2.14918138761862 0.00897766160776824 no 3303 0.0158100120492057 4702 97690
SGTC_140 0062-0056 502.533 µM -2.15048042410146 0.00894300527821044 no 3304 0.0157586164083218 4640 3758964
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -2.15273498733712 0.00888313511969594 no 3305 0.0156697560684824 4707 688669
SGTC_44 0929-0055 61.211 µM -2.15678809605766 0.00877638725791833 no 3306 0.0155110895295423 4560 1379590
SGTC_3153 9100258 49.47 µM -2.16195345406984 0.00864197665235246 no 3307 0.0153108820631362 4652 25236848
SGTC_1767 st044992 70.3 µM -2.18314076792672 0.00810935994508192 no 3308 0.0145127225672648 4715 9600693
SGTC_26 0302-0163 425.158 µM -2.18749527063349 0.00800353936203422 no 3309 0.014353194046337 4748 3100915
SGTC_2263 7948595 193.29 µM -2.21691431031359 0.00731989450202662 no 3310 0.0133144738382225 4739 2971371
SGTC_2505 galangin 7.89 µM -2.21989064816362 0.00725368391744324 no 3311 0.0132130957425696 4693 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3113 9123498 49.47 µM -2.22903908659737 0.00705346546425991 no 3312 0.0129056521158141 4779 8897275
SGTC_542 3381-0244 89.3 µM -2.23084711138661 0.00701447813332824 no 3313 0.0128456290362748 4723 1112843
SGTC_931 2812-0076 566 µM -2.23115037903303 0.00700795728432882 no 3314 0.0128355847944395 4690 3450959
SGTC_670 4204-0025 119 µM -2.24174405525434 0.00678350488255879 no 3315 0.0124889594074061 4719 719039
SGTC_3050 9093513 49.47 µM -2.25282837229102 0.00655547931199176 no 3316 0.0121349862632059 4703 25236664
SGTC_1103 duloxetine 36.1 µM -2.2734788115643 0.00614867760295684 no 3317 0.011498670780153 4750 60835 A selective serotonin reuptake inhibitor.
SGTC_2830 7992007 71.43 µM -2.2822460053324 0.00598284256257752 no 3318 0.0112374101847724 4672 1952075
SGTC_1097 itavastatin 7.23 µM -2.28262240340128 0.00597581246839087 no 3319 0.0112263100658695 4750 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1680 diphenhydramine 100 µM -2.32550796883342 0.00522123219231023 no 3320 0.0100224071540639 4702 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1952 st077036 64.1 µM -2.33459767666295 0.00507263699413469 no 3321 0.00978222402243565 4743 2937007
SGTC_1002 4049-0206 172 µM -2.35532237702682 0.00474783058001628 no 3322 0.00925332118918355 4735 4662749
SGTC_1947 st076332 61.6 µM -2.37799518582323 0.00441385333876384 no 3323 0.00870352658928732 4678 24208416
SGTC_2090 5301565 104.445 µM -2.40200644281536 0.00408319288253588 no 3324 0.00815271062419759 4752 2056344
SGTC_926 2268-1401 59.4 µM -2.41703552310908 0.00388768238131585 no 3325 0.00782374498643628 4728 2931578
SGTC_2704 st078022 71.1 µM -2.44255605239808 0.00357483398744551 no 3326 0.00729183236519876 4759 54697681
SGTC_2862 9027634 71.43 µM -2.51561318217865 0.00280032801403732 no 3327 0.00594127587873316 4746 5012562
SGTC_1812 st052057 4.327 µM -2.5213357165359 0.00274658381245764 no 3328 0.00584551262521411 4772 3645418
SGTC_691 1548-0686 185 µM -2.54789131106733 0.00250916681411007 no 3329 0.00541881154249816 4764 46495133
SGTC_2358 9037157 4 µM -2.54868063806459 0.00250240292556319 no 3330 0.00540656355563832 4746 2388925
SGTC_296 1222-0039 74.9 µM -2.56281563773114 0.00238403607130741 no 3331 0.00519135824784497 4783 5984176
SGTC_828 2074-0507 139 µM -2.6205888804797 0.00195113355558929 no 3332 0.00438890228080388 4779 X828
SGTC_2477 5967686 25.23 µM -2.65718308448205 0.00171522602459035 no 3333 0.00393983186115837 4758 776118
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -2.68227465088742 0.00156880563486249 no 3334 0.00365616992835192 4732 6708760
SGTC_672 1441-0018 53.7 µM -2.68976845200958 0.00152734008422798 no 3335 0.00357508058414701 4789 251141
SGTC_1462 k081-0014 26.5 µM -2.75323071451644 0.00121426672787344 no 3336 0.00295051470283795 4348 3270634
SGTC_2520 obtusaquinone 4.71 µM -2.78328246192824 0.00108755311536101 no 3337 0.00269059675504958 4784 5967872
SGTC_2269 7935389 174.42 µM -2.78515394623049 0.00108007791425142 no 3338 0.00267511574541836 4780 97605
SGTC_922 1866-0035 480 µM -2.82004662712293 0.000949057880254926 yes 3339 0.00240083359230975 4747 3156169
SGTC_3117 9124945 49.47 µM -2.84151444739279 0.000875873088377576 yes 3340 0.00224499087575598 4774 17592065
SGTC_1363 1636-0063 10.4 µM -2.86939008439026 0.000788585055538876 yes 3341 0.0020563212263906 4787 6072185
SGTC_1062 mesoridazine 14.2 µM -2.90901441545223 0.000678236593798299 yes 3342 0.00181285070716459 4803 4078 A neuroleptic.
SGTC_1031 k035-0009 16 µM -2.91481304940133 0.000663339380812924 yes 3343 0.0017795083426704 4792 5180959
SGTC_1094 duloxetine 25.4 µM -2.98591937915003 0.000503625614654011 yes 3344 0.0014136358496654 4791 60834 A selective serotonin reuptake inhibitor.
SGTC_3216 9129716 49.47 µM -3.00451610590067 0.000468175656836115 yes 3345 0.00133001837470983 4751 8056934
SGTC_523 1934-0222 13.7 µM -3.00561294787583 0.000466158779594366 yes 3346 0.00132523069513914 4788 1361595
SGTC_3094 9117742 49.47 µM -3.01938671575423 0.000441507493234549 yes 3347 0.00126643498686026 4782 17149698
SGTC_933 2914-0560 114 µM -3.05838137282143 0.000378117787299237 yes 3348 0.00111268083520865 4782 463887
SGTC_2835 9006588 71.43 µM -3.09952330512511 0.00032047391039948 yes 3349 0.000969161640263039 4753 2345538
SGTC_767 0929-0023 86 µM -3.28251736991 0.00015000094000353 yes 3350 0.000514423234363531 4803 1204563
SGTC_2531 methyl deoxycholate 70.07 µM -3.29358015253078 0.000143096118027172 yes 3351 0.000494600667963172 4772 16667744 Haematoxylin.
SGTC_1136 pergolide 1.05886 µM -3.33773660728342 0.000118394152094929 yes 3352 0.000422318873317482 4785 47811 A dopamine receptor agonist.
SGTC_1674 st016616 23.6 µM -3.67751410895192 2.5551595008297e-05 yes 3353 0.000117759026258961 4801 625830
SGTC_2773 thioridazine 9.09 µM -3.76267553736404 1.70383437985696e-05 yes 3354 8.4052618900016e-05 4803 5452 An antipsychotic.
SGTC_361 000s-0510 1.45 µM -3.9511340654581 6.74475126850352e-06 yes 3355 3.88908672453142e-05 4794 660
SGTC_1030 k029-0042 36.7 µM -3.9769846215229 5.92054310556849e-06 yes 3356 3.48973384182659e-05 4804 6080581