SGTCid condition conc unit ACF2|YLR144C.score ACF2|YLR144C.strain.pval ACF2|YLR144C.strain.significant ACF2|YLR144C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2756 carbadox 75.1 µM 5.31757561326889 3.82567728630604e-08 yes 1 5.25794945276817e-08 28 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_165 k038-0023 64.381 µM 4.9493935881004 2.81500805335586e-07 yes 2 3.72225330388803e-07 44 46368543 SGTC_137 0438-0332 85.389 µM 4.72469520650657 8.91113290350554e-07 yes 3 1.15230373503403e-06 87 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_617 3770-0098 35 µM 4.65583674142408 1.25596651787244e-06 yes 4 1.61333774856678e-06 8 5962639 SGTC_1829 berberine 14.4 µM 4.58516649704506 1.77763129868299e-06 yes 5 2.26812403695897e-06 10 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 4.0274360769651 2.32247986381158e-05 yes 6 2.81941955279476e-05 69 6708739 YPR165W RHO1 SGTC_2484 5809818 12.04 µM 3.81804530478859 5.63614156061445e-05 yes 7 6.72566137569935e-05 19 2870548 SGTC_2878 9043973 25.97 µM 3.77332561125253 6.77360080445636e-05 yes 8 8.05429146185532e-05 25 6465167 SGTC_1213 1315-0166 115 µM 3.51220025557605 0.000190653373700045 yes 9 0.000222206498807503 43 768401 SGTC_3335 9143315 29.6265 µM 3.5071947513925 0.000194348235336743 yes 10 0.000226428792130684 22 4899691 SGTC_129 0088-0017 176.636 µM 3.47584331354053 0.000219055832960104 yes 11 0.000254624860413886 81 182446 SGTC_174 3553-0389 74.3 µM 3.38603197613548 0.000307024410177851 yes 12 0.000354555601976382 39 738071 SGTC_228 caffeine 993.056 µM 3.36971274691358 0.000326176953810824 yes 13 0.000376232899825259 21 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1634 st006576 41 µM 3.36570721417881 0.000331044823866743 yes 14 0.000381738495617113 38 3915356 SGTC_86 0417-1630 471.922 µM 3.33654119657324 0.000368579142754751 yes 15 0.000424139278566887 191 3634867 SGTC_105 0111-0055 734.78 µM 3.3091533862156 0.000407388450667871 yes 16 0.000467892774617366 19 5179370 SGTC_2159 5658611 73.75 µM 3.21409937278885 0.00057344095009153 yes 17 0.000654271890850783 20 793844 SGTC_2018 5133068 143 µM 3.16110042646107 0.000691272026484025 yes 18 0.000785871491177012 60 785362 SGTC_810 3825-7150 143 µM 3.11809436792999 0.000802882477555383 yes 19 0.000910122556062502 31 22330411 YGL099W LSG1 SGTC_1993 st073995 70.8 µM 3.08797708627114 0.000890673495709426 yes 20 0.00100762004387342 48 3098394 SGTC_1732 st034308 51.822 µM 3.08624681924124 0.000895975766322573 yes 21 0.00101350243571265 68 830119 SGTC_2658 polymyxin b sulfate 77.05 µM 3.02590497966238 0.00110006917738939 no 22 0.00123945095554868 82 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2276 7947513 42.08 µM 3.00816611745221 0.00116770832775111 no 23 0.0013141471436936 63 2105100 SGTC_2254 7938975 95.19 µM 2.99072662658497 0.00123789854611902 no 24 0.00139157263210021 100 2969277 SGTC_809 3998-0021 90 µM 2.97664986868056 0.00129734717720039 no 25 0.00145708305592151 32 715485 SGTC_2881 9058953 51.95 µM 2.93143749425263 0.00150637775266915 no 26 0.00168698627922848 73 17122249 SGTC_1842 st055362 61.2 µM 2.90599288739892 0.00163710420277721 no 27 0.00183044885255487 64 676032 SGTC_1272 0839-0021 27 µM 2.85417888345913 0.00193576857946544 no 28 0.00215741139767432 75 5027250 SGTC_1310 1188-0297 994 nM 2.84756070382172 0.00197728812467432 no 29 0.00220278456109369 86 1588352 SGTC_600 1495-0418 41.6 µM 2.840829831578 0.00202034256539348 no 30 0.00224981577507678 56 5377768 SGTC_158 k038-0087 26.446 µM 2.82862988629678 0.00210055519518658 no 31 0.00233738636041029 225 X158 SGTC_598 3937-0236 20.2 µM 2.79110035343711 0.00236574565454945 no 32 0.0026264591469886 103 1379313 SGTC_2838 9002687 71.43 µM 2.77903233880446 0.00245724874150198 no 33 0.00272605484820715 90 6457060 SGTC_3268 9137683 49.47 µM 2.76494047804602 0.00256814071748591 no 34 0.00284665916811572 46 1953228 SGTC_3017 9080681 49.47 µM 2.76142670951848 0.00259648667164289 no 35 0.0028774715768183 77 16451914 SGTC_216 k038-0035 28.382 µM 2.75170763820653 0.00267636983942649 no 36 0.00296427113179901 103 4444231 YPR107C YTH1 SGTC_2452 5863136 48.41 µM 2.6983785568047 0.00315551464371573 no 37 0.00348390779004816 84 2184096 SGTC_3175 9106517 49.47 µM 2.69788197638763 0.00316031780983784 no 38 0.00348910880350336 67 41468073 SGTC_48 0382-0018 55 µM 2.689287000786 0.0032445017533338 no 39 0.00358024135911905 66 762596 SGTC_2271 7849410 118.62 µM 2.6758650890993 0.00338000269392312 no 40 0.00372683211169282 75 972430 SGTC_2163 5671233 125 µM 2.67169639902054 0.00342311099661549 no 41 0.00377344473175444 109 701023 SGTC_3210 9128157 49.47 µM 2.63628066491093 0.00380974102657134 no 42 0.00419101848296008 155 17590849 SGTC_2788 5282734 71.43 µM 2.6331312571384 0.00384594970749739 no 43 0.00423008227008205 151 743706 SGTC_2217 6934799 96.0675 µM 2.62617864795287 0.00392697784143762 no 44 0.00431747421247935 47 675606 SGTC_2394 5221648 200 µM 2.59345905242312 0.0043292029273521 no 45 0.00475079264646933 120 788586 SGTC_990 3985-0011 41.3 µM 2.57600596397881 0.00455848140234429 no 46 0.00499744611670646 87 5399565 YGL099W LSG1 SGTC_64 000l-0018 272.079 µM 2.54373219952766 0.00501117124214811 no 47 0.00548375671597086 277 6811119 SGTC_2302 7771753 200 µM 2.5421318998045 0.0050346254632971 no 48 0.00550892932759465 166 2203047 SGTC_3304 9125678 46.087 µM 2.5298331997862 0.0052181636819518 no 49 0.00570583815090958 148 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1425 4048-4433 7.33 µM 2.4624886236779 0.00633264444366358 no 50 0.00689882749929923 151 23734946 SGTC_2664 lyso-paf C-16 73.48 µM 2.43851979687553 0.00677742057074282 no 51 0.00737377544361979 118 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3050 9093513 49.47 µM 2.4355410590472 0.00683458000915054 no 52 0.00743476847278335 105 25236664 SGTC_3301 9125354 19.7965 µM 2.43183219337521 0.00690634485324543 no 53 0.00751133272993973 95 41905162 SGTC_3273 9137859 49.47 µM 2.4233296448381 0.00707338176477572 no 54 0.00768948219191383 66 2377234 SGTC_2709 st078560 56 µM 2.4226020678396 0.00708783961497561 no 55 0.00770489809488478 92 17250903 SGTC_1124 fisetin 1.16336 µM 2.41050158467858 0.00733214324071856 no 56 0.00796530105817124 151 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2816 7982706 58.44 µM 2.40095439618973 0.00753010515545724 no 57 0.0081761871330352 165 2981853 SGTC_609 0986-0026 86.3 µM 2.40001713077255 0.00754979092258743 no 58 0.00819715229687761 164 2848610 SGTC_1297 1068-0111 14.1 µM 2.39252465175454 0.00770879468171068 no 59 0.00836645198812144 114 767057 SGTC_2164 5685496 200 µM 2.38145418725409 0.00794912405929165 no 60 0.00862221779169091 112 759046 SGTC_2161 5662504 8.5105 µM 2.37476155978042 0.00809758893266684 no 61 0.008780144878173 137 2859334 SGTC_142 0335-0849 62.6745 µM 2.34121725367085 0.00887901407960435 no 62 0.00961048934490502 290 3889043 YPR107C YTH1 SGTC_3199 9111318 49.47 µM 2.33507773576003 0.00902897922145049 no 63 0.00976968008886829 147 8548020 SGTC_3318 9139014 38.6185 µM 2.32616127129322 0.00925072393938138 no 64 0.0100049744425682 115 16643984 SGTC_1944 st076371 56.9 µM 2.3195800552463 0.00941743614050345 no 65 0.0101818029109197 167 24208455 SGTC_763 3453-1109 128 µM 2.29624097604538 0.010030016672849 no 66 0.0108310534208584 146 1560353 SGTC_924 2046-0044 21.3 µM 2.28925465924744 0.0102200243106419 no 67 0.0110322802183695 125 3623589 SGTC_1462 k081-0014 26.5 µM 2.28686544986537 0.010285720482504 no 68 0.0111018389082702 87 3270634 SGTC_145 3737-0113 38.366 µM 2.28149988741588 0.0104346011023868 no 69 0.0112594416825243 248 6849351 SGTC_461 N-acetylfarnesylcysteine 136 µM 2.28018052679541 0.0104714964181862 no 70 0.0112984918930014 63 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1467 k284-1082 293 µM 2.26149624980508 0.0110063278803865 no 71 0.0118642723295532 155 3334705 SGTC_521 r062-0005 13.8 µM 2.23293907549609 0.0118696659621864 no 72 0.0127764811513093 146 2832033 SGTC_1111 tnp00062 510.699 nM 2.22601969998854 0.0120874876600509 no 73 0.0130064309497559 133 676306 SGTC_661 1304-0007 33.6 µM 2.21959146621905 0.0122929449564618 no 74 0.013223256044909 151 3117130 SGTC_2218 6965428 192.983 µM 2.21894039722827 0.0123139220026896 no 75 0.0132453898595076 128 675684 SGTC_812 4251-0442 148 µM 2.21484759130541 0.0124465012593235 no 76 0.0133852636845662 124 5723007 SGTC_1526 st051518 75 µM 2.2147990488687 0.012448081095015 no 77 0.0133869302730227 155 673993 SGTC_927 2425-1185 123 µM 2.20456704885228 0.0127849861364869 no 78 0.0137422450742551 170 730375 SGTC_508 roscovitine 141 µM 2.19439302444785 0.0131277748936727 no 79 0.0141035834783749 116 160355 A CDKinase inhibitor. SGTC_77 0828-0286 12.516 µM 2.18434840042994 0.0134739669141851 no 80 0.0144683283772938 210 745345 SGTC_3058 9093861 49.47 µM 2.18250150701479 0.0135384714397825 no 81 0.0145362700789917 183 17217477 SGTC_3070 9117005 49.47 µM 2.16873561519712 0.0140277097637753 no 82 0.0150513809116029 101 8779016 SGTC_1036 k216-0215 33.5 µM 2.16224311582035 0.0142636922246299 no 83 0.0152997208924966 246 622330 SGTC_1619 st003326 88.7 µM 2.136057682981 0.0152504786246673 no 84 0.0163373562074283 145 2849032 SGTC_588 3970-1144 52.9 µM 2.13404021701851 0.0153288821496624 no 85 0.0164197444376579 206 1888707 SGTC_2593 nobiletin 86.24 µM 2.13392064049845 0.0153335400240553 no 86 0.0164246387889148 187 72344 An anti-infammatory. SGTC_264 promethazine 12.5 mM 2.11200560596136 0.0162079781050973 no 87 0.0173429842325689 286 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3067 9117431 49.47 µM 2.10894932161301 0.0163332590461568 no 88 0.0174744781296425 154 17150885 SGTC_2047 4141938 200 µM 2.09777974851802 0.016798191925794 no 89 0.0179623031394585 150 3807862 SGTC_2165 5727197 32.143 µM 2.09695549235006 0.016832945634358 no 90 0.0179987577325203 228 1361712 SGTC_2162 5663267 200 µM 2.09666111731433 0.0168453724757087 no 91 0.0180117924129608 157 6456493 SGTC_2665 lovastatin 100 µM 2.09283119302758 0.0170077665206615 no 92 0.0181821131117966 178 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2413 inermin 26.06 µM 2.09191245977571 0.0170469204950467 no 93 0.0182231736482552 248 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1218 1348-1416 30.7 µM 2.09128342415325 0.0170737727378362 no 94 0.018251332406548 190 6787668 SGTC_513 4245-1575 41.7 µM 2.07901516274593 0.0176047530246539 no 95 0.0188079784157474 361 719745 SGTC_2656 pseudo-anisatin 100 µM 2.07491696871202 0.0177852383814341 no 96 0.0189971153821961 105 6708809 A neurotoxin. SGTC_2521 angolensin 13.4 µM 2.062778185731 0.0183291223608755 no 97 0.0195668537588893 161 821428 A flavenoid. SGTC_3258 9138477 49.47 µM 2.06153465998823 0.0183856309446095 no 98 0.0196260301749454 178 4970355 SGTC_1715 st032160 10.2275 µM 2.05110167142949 0.0188656009445712 no 99 0.0201285232963763 206 5289825 SGTC_566 0958-0068 16.5 µM 2.03204220794708 0.019769978152086 no 100 0.0210746915884036 183 6815365 SGTC_300 r073-0011 5.04 µM 2.02823626885951 0.0199549120986849 no 101 0.0212680699573377 230 2735780 SGTC_1303 1160-0052 261 µM 2.02630820963343 0.0200491569597051 no 102 0.0213666052491081 204 3562476 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.02220010706183 0.0202512236379043 no 103 0.021577841617467 284 368090 SGTC_3350 9150499 3.57 µM 2.01653304116876 0.0205328033351247 no 104 0.0218721333870243 273 4910996 YPR165W RHO1 SGTC_1518 st038567 90.8 µM 2.01188763502273 0.0207660871856353 no 105 0.0221158915643181 181 77966 SGTC_2023 5144124 124 µM 2.01077609148416 0.0208222384399642 no 106 0.0221745562884919 211 2830192 SGTC_626 0214-0009 33 µM 2.00090867762663 0.0213263643025799 no 107 0.0227011161246897 215 3437874 SGTC_113 0099-0221 2.5 µM 1.992809521822 0.0217478265045958 no 108 0.0231411543564416 218 89219 SGTC_2939 9044578 71.43 µM 1.99085390458041 0.02185064053922 no 109 0.0232484755664198 234 2653634 SGTC_603 3794-0023 45.9 µM 1.98009026239918 0.0224239001391828 no 110 0.0238466935694702 184 3802260 SGTC_460 trequinsin 123 µM 1.97576314667767 0.0226579058697175 no 111 0.0240908046081751 154 5537 A vasodilator. SGTC_1327 1436-0082 2.18 µM 1.97503605192631 0.0226974276664801 no 112 0.0241320284404874 219 15992205 SGTC_1005 4092-0690 4.4 µM 1.97008324917722 0.0229681898571351 no 113 0.0244144151781101 229 1529343 SGTC_624 k048-0052 28 µM 1.96508193124971 0.0232443599285464 no 114 0.0247023777684132 211 6835531 SGTC_966 1300-0360 30.2 µM 1.9622812284467 0.023400230497977 no 115 0.0248648757194142 244 70588 SGTC_1395 3486-0190 4.35 µM 1.95564485564338 0.0237730859404184 no 116 0.0252535024814637 224 6748079 SGTC_3104 9120930 49.47 µM 1.95458225024379 0.0238332484123345 no 117 0.0253161990170699 190 17014836 SGTC_2846 9008642 19.48 µM 1.95439492006607 0.0238438679104034 no 118 0.025327265504293 207 2992898 SGTC_2406 ethylparaben 405.7 µM 1.95173559828074 0.0239950508283616 no 119 0.0254848019360366 230 8434 A possible steroid mimic. SGTC_2366 9070441 60.58 µM 1.95165114954696 0.0239998649195493 no 120 0.0254898180353584 253 6837235 SGTC_2790 5423970 71.43 µM 1.9508550234198 0.0240452888517982 no 121 0.0255371471132726 301 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1301 naphtanilide LB 4.81 µM 1.94013337425934 0.0246640948341632 no 122 0.026181741479488 222 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1322 1348-1070 12 µM 1.92416772615741 0.025610284939127 no 123 0.0271667815494342 175 6758089 SGTC_99 0109-0120 622.8 µM 1.92125553351739 0.025786109856066 no 124 0.0273497500436002 198 759414 SGTC_964 1287-0107 19.4 µM 1.9176133101656 0.0260074314423837 no 125 0.0275800305792064 276 51516812 YPR165W RHO1 SGTC_2138 5575593 77.673 µM 1.91676795662765 0.0260590263627596 no 126 0.0276337087551572 196 762213 SGTC_322 k048-0136 19.3 µM 1.91515411696498 0.0261577624455917 no 127 0.0277364259891237 218 6823282 SGTC_1914 st062367 72.6 µM 1.90978832085588 0.026488298228998 no 128 0.0280802368237571 226 978205 SGTC_407 eburnamonine 100 µM 1.89744254400823 0.0272620738154712 no 129 0.0288847775595145 215 3195 SGTC_2160 5660466 132.927 µM 1.88485293800932 0.0280704576118521 no 130 0.0297248477296641 232 2859134 SGTC_2865 9030313 51.95 µM 1.88429888339913 0.028106487405825 no 131 0.0297622791914147 207 42562754 SGTC_3016 9080866 49.47 µM 1.8823374548701 0.0282343473487419 no 132 0.0298951060599729 269 17066299 SGTC_729 4092-0585 94.1 µM 1.8787091483488 0.0284721425234743 no 133 0.0301421089925779 248 2169061 SGTC_9 0092-0002 10.449 µM 1.87690766868961 0.0285908271252446 no 134 0.0302653748219751 261 759368 SGTC_876 0720-0963 56.8 µM 1.87277236103446 0.0288648253982988 no 135 0.0305499130818271 246 765861 SGTC_2856 9022925 19.48 µM 1.86962720921291 0.0290746760269142 no 136 0.0307678020519694 277 4944862 SGTC_1515 3460-0031 42.1 µM 1.86505457023808 0.0293820312879819 no 137 0.0310868777612068 195 2876596 SGTC_1797 st048695 56.8 µM 1.86302798533676 0.0295191108226609 no 138 0.031229164497084 283 592262 YIL048W NEO1 SGTC_210 3551-0445 56.827 µM 1.84549649409978 0.0307272525281711 no 139 0.0324826740102635 292 2865180 YOR207C RET1 SGTC_2874 9043904 71.43 µM 1.83894838366153 0.0311888770228451 no 140 0.0329613891825142 206 4463428 SGTC_3339 9145883 14.936 µM 1.83419366667229 0.0315276548600436 no 141 0.033312625614285 242 2030670 SGTC_2651 TUB2.036 5 µM 1.83059656463045 0.031785967798449 no 142 0.0335803908525096 505 15992207 YFL037W TUB2 SGTC_3102 9121669 49.47 µM 1.82952107922881 0.0318635385843112 no 143 0.0336607922300167 212 41905072 SGTC_2453 5731132 22.18 µM 1.82067895148369 0.0325072339183306 no 144 0.0343278367891971 274 1362040 SGTC_2131 toluylene red 5.2905 µM 1.80984960149116 0.0333101716822889 no 145 0.0351595567547388 303 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2216 7189485 200 µM 1.80571035621075 0.0336213577760496 no 146 0.0354817970773749 199 731273 SGTC_2358 9037157 4 µM 1.78719896401607 0.0350424436760684 no 147 0.0369526683541578 295 2388925 SGTC_2278 7948257 134.34 µM 1.78325535224318 0.0353514699605661 no 148 0.0372723728622424 276 1247028 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.7757017562545 0.0359496190477706 no 149 0.0378910438899011 282 688669 SGTC_2043 5101342 149 µM 1.77434145211854 0.0360582138681612 no 150 0.0380033439467614 308 678451 SGTC_842 0271-0008 11.1 µM 1.77119402062707 0.0363105074850587 no 151 0.0382642216238568 307 1221709 SGTC_1689 st020265 53.493 µM 1.76571133613338 0.0367534414793634 no 152 0.0387221449796331 272 5758320 YPR016C TIF6 SGTC_2273 7815444 169.05 µM 1.76273580251696 0.0369956721296744 no 153 0.0389725296742407 291 2824616 SGTC_2312 7706453 155.7 µM 1.7616869336418 0.037081368351568 no 154 0.039061103350975 315 976098 SGTC_2926 9010726 65.15 µM 1.76157350853178 0.0370906452892106 no 155 0.0390706915564381 318 2994293 SGTC_1624 st003710 6.25 µM 1.76122418929989 0.0371192277117119 no 156 0.0391002327220076 355 24207033 SGTC_116 0155-0182 31.788 µM 1.75888308510316 0.037311249268461 no 157 0.0392986843770306 451 771486 SGTC_2826 7992541 19.48 µM 1.74773280319196 0.0382369818472355 no 158 0.040255152917237 304 2985066 SGTC_299 1273-0059 1.44 µM 1.74617513450645 0.0383677829698529 no 159 0.0403902620901254 274 2848077 SGTC_950 1165-0508 94.1 µM 1.74352999227918 0.0385907373131265 no 160 0.0406205400139329 317 6148369 SGTC_2799 7812892 81.82 µM 1.73615497718147 0.0392179441476582 no 161 0.0412682178156792 320 20205235 SGTC_1792 st045773 43.6 µM 1.73407160210505 0.039396619576255 no 162 0.0414526897357229 313 2919270 SGTC_963 1269-2853 151 µM 1.73127724208658 0.0396373101377084 no 163 0.0417011642239926 307 3668223 SGTC_341 1486-1430 230 µM 1.72479727685228 0.0402000613664886 no 164 0.0422820063435883 318 2054753 YPL210C SRP72 SGTC_941 3237-0776 460 µM 1.7243752717506 0.0402369342721175 no 165 0.0423200593455338 279 760008 SGTC_1506 4226-2149 212 µM 1.72296555708101 0.0403603079978067 no 166 0.0424473768984316 371 991114 SGTC_824 1304-0008 100 µM 1.71970184535573 0.0406471166750992 no 167 0.0427433261153884 360 768245 SGTC_1852 st056254 31.4 µM 1.70979774688813 0.0415276089535702 no 168 0.0436516399054766 292 442583 SGTC_796 1234-0020 70.7 µM 1.70214901798905 0.0422181180084472 no 169 0.0443637184984577 325 46495034 SGTC_1463 k081-0032 34.1 µM 1.69996212836166 0.0424172440965025 no 170 0.0445690246658468 232 977755 SGTC_778 3456-2434 196 µM 1.69815613230122 0.0425822602451061 no 171 0.0447391487898177 416 5539063 SGTC_3074 9116018 49.47 µM 1.6946493042537 0.0429041660101173 no 172 0.0450709840214367 283 17027303 SGTC_1419 3993-2473 62.6 µM 1.69454742106827 0.0429135475902305 no 173 0.0450806542948004 306 704026 SGTC_674 0498-0004 451 µM 1.693765602554 0.0429855939723939 no 174 0.0451549164154809 350 4231473 SGTC_2477 5967686 25.23 µM 1.68955285875447 0.0433754917861496 no 175 0.0455567655839439 344 776118 SGTC_441 propafenone 146 µM 1.67900432157994 0.0443643140158063 no 176 0.0465756007614511 272 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2911 7942208 15.64 µM 1.67237080434189 0.0449953905747039 no 177 0.0472256127607939 294 1243384 SGTC_1288 0973-0013 65.5 µM 1.67165080797835 0.0450643196250442 no 178 0.0472965998202305 338 4315430 SGTC_2860 9025725 38.96 µM 1.66629260360574 0.0455799620627026 no 179 0.0478275745966842 301 40546248 SGTC_2585 alliin 100 µM 1.65844470042756 0.0463437495685168 no 180 0.0486138702639324 378 87310 A garlic compound which reacts with lipids. SGTC_430 0958-0115 16.4 µM 1.65704220852762 0.0464813215291207 no 181 0.0487554709167537 355 6833180 SGTC_1531 st059297 52.4 µM 1.65527663676507 0.0466549742410877 no 182 0.0489341979232392 349 7566702 SGTC_3353 9151644 39.2805 µM 1.65469202494858 0.0467125882897003 no 183 0.048993492804879 344 4909158 SGTC_1107 amlodipine 47 µM 1.65106679101159 0.0470711341143552 no 184 0.0493624687107345 370 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_531 3788-1495 174 µM 1.65095322574468 0.0470824015824196 no 185 0.049374063109939 345 2896655 SGTC_37 0566-0070 1.56 µM 1.65023793924071 0.0471534190107945 no 186 0.0494471399712836 384 1626686 SGTC_1293 1000-1278 195 µM 1.64764181872498 0.0474118973050347 no 187 0.0497130968239642 371 678847 SGTC_3331 9141060 1.957 µM 1.6422331683776 0.0479540464495689 no 188 0.050270845653183 333 4906567 YPR165W RHO1 SGTC_1437 4092-1038 11.6 µM 1.64194459134617 0.0479831115382078 no 189 0.0503007437726698 354 3977136 SGTC_571 k831-0106 44.2 µM 1.64189651775862 0.047987954814824 no 190 0.0503057258295012 313 4783639 SGTC_1856 st057054 55.7 µM 1.63478156465593 0.0487090912524674 no 191 0.0510474233689767 365 1266018 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.63304950925644 0.048885948411535 no 192 0.0512292922073541 412 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3059 1327-0034 3 µM 1.62567369006191 0.0496448327510771 no 193 0.0520095449208964 389 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1182 1222-0449 220 µM 1.622502002035 0.0499740387873747 no 194 0.0523479523946767 323 658318 SGTC_2246 7293507 91.5585 µM 1.62238939928766 0.0499857583366123 no 195 0.052359998754879 372 887656 SGTC_2947 9072639 7.68 µM 1.6209255106489 0.0501383175262952 no 196 0.0525168074855859 413 16488146 SGTC_272 doxorubicin 8.13 µM 1.62057414132977 0.0501749906741488 no 197 0.0525545008601306 408 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_363 0455-0021 3.06 µM 1.61724829910701 0.0505231757966263 no 198 0.0529123471962179 408 4597466 SGTC_1831 st055328 12 µM 1.61712880578585 0.050535721380853 no 199 0.0529252400416595 367 1103068 SGTC_1949 st076024 69.1 µM 1.61308925404734 0.0509612951921383 no 200 0.0533625590741559 386 2921930 SGTC_1205 4161-2785 76 µM 1.60692431818327 0.0516162756650343 no 201 0.0540354855496062 343 3498106 SGTC_642 0335-0876 158 µM 1.60624192134221 0.0516891850358656 no 202 0.0541103828767424 398 6812350 SGTC_3196 9111891 49.47 µM 1.60010381349578 0.0523486852534819 no 203 0.0547877775762594 319 18891510 SGTC_2265 7929201 200 µM 1.5993453327625 0.0524306408703606 no 204 0.0548719459756472 375 1265108 SGTC_1372 2752-0194 270 µM 1.59841788131182 0.0525309925571132 no 205 0.0549750038559143 344 823334 SGTC_3302 9125395 16.351 µM 1.59214622939283 0.0532136018173018 no 206 0.0556759258785918 355 17599668 SGTC_1895 st058434 18.3 µM 1.58984870711518 0.0534654178726798 no 207 0.0559344559150114 372 5393175 SGTC_2356 9061756 188.97 µM 1.58967358808425 0.0534846501611563 no 208 0.0559542000628415 323 20104043 SGTC_1986 st071812 45 µM 1.58948664136893 0.0535051874633421 no 209 0.0559752838134383 321 11838594 SGTC_1600 coumarin 106 71.1 µM 1.5886497622274 0.0535972006359194 no 210 0.0560697434202101 385 100336 A hepatotoxic, DNA x-linker. SGTC_819 1013-0258 27.7 µM 1.58550631285329 0.0539439367140479 no 211 0.0564256718768812 393 5753198 SGTC_173 1273-0061 2.693 µM 1.58393573036651 0.0541178428285645 no 212 0.0566041726806629 474 2847414 YPL266W DIM1 SGTC_781 4335-2806 94.4 µM 1.5835320332831 0.0541626146615133 no 213 0.0566501257101176 424 845254 SGTC_2079 5212404 121 µM 1.5797846245154 0.054579619515 no 214 0.0570780989609606 350 758462 SGTC_1901 st060216 58.6 µM 1.57633194324506 0.0549660709866803 no 215 0.0574746618430246 388 688792 SGTC_2250 alverine citrate 130 µM 1.57279331582601 0.05536438264816 no 216 0.0578833419427035 562 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1184 1269-1718 139 µM 1.57125617813966 0.0555381130312492 no 217 0.0580615778562586 384 5403821 SGTC_1955 wogonin 32.4 µM 1.57040896349972 0.0556340507289125 no 218 0.058159999240742 361 5281703 A flavanone. SGTC_738 1315-0003 72.4 µM 1.56737291445589 0.0559789243542496 no 219 0.0585137755898705 399 6251474 SGTC_2374 9071832 200 µM 1.56627240377116 0.0561043501636673 no 220 0.0586424293193374 339 17381698 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.56601784667527 0.0561333937124866 no 221 0.0586722195750415 374 6710655 SGTC_1521 st012942 49.4 µM 1.56562695976753 0.0561780148136632 no 222 0.0587179873324487 423 24207259 SGTC_304 1310-0298 97 µM 1.55911203046827 0.0569258417688664 no 223 0.0594849333618704 447 1550234 SGTC_309 k408-0051 1.48 µM 1.5564110806646 0.0572381640541511 no 224 0.0598051859869477 480 3640463 SGTC_36 0335-0881 14.2 µM 1.55302089771287 0.0576320921302832 no 225 0.0602090710777952 491 23828853 SGTC_3244 9134489 49.47 µM 1.54682644979162 0.0583573703219356 no 226 0.0609525501997623 384 16584271 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.54601767561348 0.0584525925917152 no 227 0.0610501495316292 388 7104 SGTC_2587 piperic acid 92.2 µM 1.54594089755077 0.0584616385123689 no 228 0.0610594211175634 372 5370536 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.5456931812025 0.0584908317196755 no 229 0.0610893424188801 391 803109 SGTC_420 mitomycin C 81.9 mM 1.54510571561653 0.0585601099118959 no 230 0.0611603473570575 420 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2513 baicalein 25.65 µM 1.54505516418763 0.0585660743112107 no 231 0.0611664603463296 387 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1246 0422-0085 105 µM 1.54283579001848 0.0588284015117885 no 232 0.0614353116526039 444 264295 SGTC_204 PMA1.184 62.41 µM 1.54266704446712 0.0588483846805566 no 233 0.0614557909085317 445 2252213 YGL008C PMA1 SGTC_2824 7998404 51.95 µM 1.54176394668707 0.0589554217871777 no 234 0.0615654830828198 375 837851 SGTC_2306 7482397 179.52 µM 1.53993044327595 0.0591732023902652 no 235 0.0617886545680712 393 891448 SGTC_3208 9114115 49.47 µM 1.53872471383705 0.059316760538282 no 236 0.0619357581325475 402 650895 SGTC_549 1661-1316 519 µM 1.53817639883565 0.0593821350046264 no 237 0.0620027449850375 399 2857282 SGTC_3355 9151058 44.0485 µM 1.53616236981798 0.0596227484236017 no 238 0.0622492813037575 391 17015728 SGTC_112 phenothiazine 287.218 µM 1.53513681457849 0.0597455633931995 no 239 0.0623751124794775 397 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_945 3381-0768 11.3 µM 1.5291408507507 0.060467578918882 no 240 0.063114765074995 426 1126236 YIL048W NEO1 SGTC_2690 usnic acid 100 µM 1.52307684970725 0.061204713166347 no 241 0.0638697399654943 481 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_89 0302-0250 142.109 µM 1.52005690905072 0.0615744242531404 no 242 0.0642483366730483 441 4203518 YLR208W SEC13 SGTC_2762 leflunomide 42.06 µM 1.51310866886538 0.0624316720662222 no 243 0.065126028993353 463 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1252 0493-0875 34.8 µM 1.5119435642289 0.0625763250125194 no 244 0.0652741100926198 408 3960963 SGTC_625 k213-0058 121 µM 1.51052045646168 0.0627533645002892 no 245 0.0654553368061152 600 3655420 SGTC_2068 5226020 147 µM 1.51002587289617 0.0628149837087113 no 246 0.0655184112129631 464 1810509 SGTC_655 k060-0012 42 µM 1.50734165441461 0.0631502279159904 no 247 0.0658615528839362 408 5994525 SGTC_200 k038-0079 37.545 µM 1.50513397606731 0.063426997721728 no 248 0.0661448177173497 400 3436683 SGTC_195 4234-0266 16.654 µM 1.4974675321197 0.0643954528237248 no 249 0.067135823843298 477 2303354 SGTC_1391 3442-0225 151 µM 1.49500218075247 0.064709315238525 no 250 0.0674569365030441 355 5227075 SGTC_2817 7995342 71.43 µM 1.48980770168484 0.0653745086665826 no 251 0.0681374027463125 362 18879975 SGTC_288 1315-0019 35.1 µM 1.48351981330378 0.0661868038858203 no 252 0.0689681781444796 438 6811474 SGTC_131 0141-0277 33.849 µM 1.482260606404 0.0663504089901087 no 253 0.0691354829306518 453 1547771 SGTC_362 0310-0100 9.03 µM 1.47665310275672 0.0670827805746999 no 254 0.0698843246577137 462 790235 SGTC_2913 7966556 36.57 µM 1.46906697538428 0.068083501941107 no 255 0.0709073120441455 396 2976516 SGTC_17 0960-0276 49.807 µM 1.46817344693002 0.0682021261274555 no 256 0.0710285574965177 485 6821114 SGTC_1651 st011928 86.1 µM 1.46437386738259 0.0687083377071916 no 257 0.0715459121557029 435 720198 SGTC_1879 gemcitabine 100 µM 1.45855176441042 0.0694896214661599 no 258 0.0723442589647365 432 60750 A nucleoside analog which inhibits DNA replication. SGTC_2456 5770359 74.46 µM 1.45809389986037 0.0695513525436792 no 259 0.0724073312928642 426 3118787 SGTC_1746 st038117 42 µM 1.45232413357494 0.0703328780341629 no 260 0.0732057500590321 462 2898218 SGTC_2922 7999257 32.47 µM 1.44859722723702 0.0708412727820038 no 261 0.0737250479977022 392 2988377 SGTC_615 k087-0205 167 µM 1.44780063693896 0.0709503025770502 no 262 0.0738364072980591 430 9642773 SGTC_705 1124-0212 310 µM 1.44467142816384 0.0713798472519762 no 263 0.0742750995055627 469 9554485 SGTC_1325 1431-0015 227 µM 1.44177164596218 0.071779677928977 no 264 0.0746834021005755 420 1103340 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.43958646809873 0.0720821101026388 no 265 0.0749922151619206 497 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1387 3342-1166 1.8 µM 1.43868169317335 0.0722076180129674 no 266 0.0751203642406565 356 3418228 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.43718423735474 0.0724157089055068 no 267 0.0753328253137989 503 5379071 SGTC_1295 1013-0063 9.78 µM 1.43121825181864 0.0732493237682628 no 268 0.0761838370929028 477 6826038 SGTC_509 pifithrin 175 µM 1.42531861609686 0.0740808675459549 no 269 0.0770325606312342 421 4817 A p53 inhibitor. SGTC_3322 9139058 2.11 µM 1.42114558965241 0.0746733895643049 no 270 0.0776372193630485 461 4908926 YPR165W RHO1 SGTC_2830 7992007 71.43 µM 1.42102384580486 0.0746907299352502 no 271 0.077654913614449 445 1952075 SGTC_3224 9130643 49.47 µM 1.42080726594817 0.0747215857019268 no 272 0.0776863988994168 456 17644395 SGTC_2467 5474540 200 µM 1.41983992838034 0.0748595194059842 no 273 0.0778271438608499 471 5413519 SGTC_880 0833-0487 87.2 µM 1.4192955991489 0.0749372212560831 no 274 0.077906427312776 460 76075 SGTC_2617 dihydrotanshinone i 20.83 µM 1.41701317906625 0.0752637018429121 no 275 0.078239537174076 499 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1103 duloxetine 36.1 µM 1.41584653649096 0.0754309982774069 no 276 0.078410220520014 526 60835 A selective serotonin reuptake inhibitor. SGTC_551 k048-0028 34.9 µM 1.40985536372133 0.0762945996994108 no 277 0.0792911975147069 500 6836383 SGTC_2768 sulfasalazine 50.2 µM 1.40642016469739 0.0767931511513292 no 278 0.0797996979703536 467 5384001 An antioxidant and salicylic acid derivative. SGTC_2723 salbutamol 83.58 µM 1.40590450768485 0.0768682019375585 no 279 0.0798762413060274 363 9884233 β2-adrenoceptor agonist SGTC_1739 st037196 92.5 µM 1.40125386995449 0.0775475955650355 no 280 0.0805690851960028 498 612214 SGTC_2942 9052777 62.25 µM 1.39636267083072 0.078267041182667 no 281 0.0813026551064116 535 6469503 SGTC_1693 xanthone 101.9 µM 1.39549875181327 0.0783946391899332 no 282 0.0814327454624537 503 7020 An insecticide. SGTC_1790 st045711 43.5 µM 1.395246377143 0.0784319438531891 no 283 0.0814707780721856 475 585119 SGTC_2135 5326629 150.42 µM 1.39202985923617 0.0789085717298031 no 284 0.0819566781146232 460 5020077 SGTC_2663 amphotericin b 100 µM 1.39015413174971 0.079187530544326 no 285 0.0822410392375058 459 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_85 0868-0259 160.055 µM 1.39005032137024 0.0792029910368502 no 286 0.082256798610951 468 83173 SGTC_2464 5717415 7.67 µM 1.38532390444647 0.0799093201928063 no 287 0.0829767237548235 513 5285744 SGTC_3036 9090181 49.47 µM 1.38477346660819 0.0799918878879262 no 288 0.0830608733053147 453 25236586 SGTC_3245 9134821 49.47 µM 1.38420025910026 0.0800779396646818 no 289 0.0831485720281849 503 17014901 SGTC_3280 9140961 49.47 µM 1.3841880100532 0.0800797792949143 no 290 0.0831504468486608 457 4901226 SGTC_3141 9094609 49.47 µM 1.3833487564681 0.0802058991819602 no 291 0.0832789774388593 472 25236309 YDL196W YDL196W SGTC_782 0083-0095 30.5 µM 1.38318379220301 0.0802307070395689 no 292 0.0833042590563484 542 3591729 An indicator and reagent. SGTC_1588 farnesol 29.9 µM 1.38306555193222 0.0802484919601308 no 293 0.0833223835322669 488 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_317 4495-0002 170 µM 1.38069277447697 0.0806060196005969 no 294 0.0836867219443791 440 15991618 SGTC_1016 4226-1401 38 µM 1.37979316336808 0.0807418861585051 no 295 0.0838251691047679 499 2901613 SGTC_741 4582-0002 126 µM 1.37530932417544 0.0814216519057272 no 296 0.0845177835063202 501 2912688 SGTC_1453 4237-0541 195 µM 1.37371344182884 0.081664631975177 no 297 0.0847653310966741 484 739892 SGTC_888 0916-0002 6.97 µM 1.37021037253865 0.0821999060111335 no 298 0.085310620671644 502 2802138 YIL048W NEO1 SGTC_3146 9095609 49.47 µM 1.36949027580067 0.0823102645395089 no 299 0.0854230362012547 480 17173999 SGTC_1622 st003707 19.4 µM 1.36808576412508 0.0825258341646847 no 300 0.0856426161014546 534 10140899 SGTC_1757 st041620 31.8375 µM 1.36539656156617 0.0829397683620499 no 301 0.0860642220081738 496 5289815 SGTC_703 3875-0075 71.8 µM 1.36392072550719 0.0831675984663162 no 302 0.086296258549784 504 2850814 SGTC_1832 st054113 55 µM 1.36000282886387 0.0837747007737642 no 303 0.0869145143515536 456 1251267 SGTC_1326 1431-2094 10.8 µM 1.35939449381198 0.083869263859042 no 304 0.087010807489327 529 616278 SGTC_1018 4259-0013 28.1 µM 1.35809280789028 0.0840718746277944 no 305 0.0872171185304247 494 6801262 SGTC_2654 protoveratrine a 100 µM 1.35468206944898 0.0846045075289227 no 306 0.0877594365224205 487 5702278 A heart drug and vasodilator. SGTC_1999 st074831 12.5 µM 1.35335431777034 0.0848125369483927 no 307 0.0879712320289423 527 17112523 SGTC_87 0100-0052 35.5 µM 1.35174047877903 0.0850659060500249 no 308 0.0882291754882177 747 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2953 9074162 66.49 µM 1.34280680599761 0.0864787431032163 no 309 0.0896672695084576 483 16451992 SGTC_3276 9139060 49.47 µM 1.33875373758553 0.087125480353077 no 310 0.0903254279204354 443 4870619 SGTC_1435 4092-0789 56.7 µM 1.33633746545765 0.0875127530986514 no 311 0.0907194979876604 528 2248285 SGTC_327 1273-0057 3.96 µM 1.33586016425134 0.0875894052019736 no 312 0.0907974917773465 498 3108138 SGTC_568 1193-0097 7.48 µM 1.33379516827635 0.0879216101709656 no 313 0.0911354974615852 560 3646150 SGTC_2725 haloperidol 53.21 µM 1.3309192448444 0.0883858369404753 no 314 0.0916077920724286 519 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_262 fenpropimorph 62.5 µM 1.33088952393063 0.0883906439577823 no 315 0.0916126823995244 467 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2198 6589944 200 µM 1.32946941896828 0.0886205567645529 no 316 0.0918465742622217 414 5290268 SGTC_203 k066-0004 30.888 µM 1.32793882052771 0.0888688567547513 no 317 0.0920991593815455 620 6795412 SGTC_653 0203-0016 55.2 µM 1.31921097057822 0.0902946297633931 no 318 0.0935492958346463 529 295302 SGTC_658 3253-0951 102 µM 1.3180873946292 0.09047940338974 no 319 0.093737196859749 652 1184878 SGTC_2691 st077356 60.2 µM 1.31580878916018 0.0908549849129728 no 320 0.0941191142715333 549 2839272 SGTC_1889 st059080 5.18 µM 1.3154052768727 0.0909216160518667 no 321 0.0941868665085962 575 176925 Isolated from Daphnopsis sellowiana. SGTC_3283 9109332 35.8195 µM 1.31297246591275 0.0913241093691319 no 322 0.0945961131840404 443 17027281 SGTC_1884 5633444 25 µM 1.31223498813174 0.091446380963563 no 323 0.0947204299871643 566 5724239 SGTC_854 0422-0053 192 µM 1.3107687558431 0.0916898382272453 no 324 0.0949679507012334 521 3596728 SGTC_2242 6630449 61.2675 µM 1.30967693665501 0.0918714385975763 no 325 0.0951525744775521 462 691249 YDR170C SEC7 SGTC_1474 0330-0125 5.35 µM 1.30841708815891 0.0920813178782947 no 326 0.0953659398852937 533 X1474 SGTC_2062 5245942 200 µM 1.30674200462225 0.0923609210277694 no 327 0.0956501738533991 569 1376160 SGTC_2044 5102272 200 µM 1.3052883669684 0.0926040694354906 no 328 0.0958973368728656 490 592666 SGTC_2444 5485484 36.41 µM 1.30227398140941 0.0931097908906498 no 329 0.096411371355668 564 6790631 SGTC_1241 0364-0022 50.8 µM 1.30092916484603 0.0933360671652066 no 330 0.0966413510662458 577 4563895 SGTC_640 3381-0960 37.1 µM 1.29994670294126 0.0935016309582628 no 331 0.0968096183439412 569 1745025 SGTC_1509 1326-1131 80 µM 1.29802014050407 0.0938269234366371 no 332 0.0971402071023902 502 768313 SGTC_510 ag-490 170 µM 1.2976677786792 0.093886508596971 no 333 0.0972007601958379 568 5328779 SGTC_1612 st002233 45.4 µM 1.29646127293825 0.094090742903959 no 334 0.0974083070172406 531 1035021 SGTC_774 k060-0086 136 µM 1.29521944764368 0.094301298148134 no 335 0.0976222689208725 616 5911235 SGTC_1204 4049-0315 18.3 µM 1.29499137872003 0.0943400056681894 no 336 0.0976616017820829 537 588402 SGTC_2855 9016525 58.44 µM 1.29151701644813 0.0949311188622761 no 337 0.0982622292073004 550 43811474 SGTC_3232 9132874 49.47 µM 1.29146813689581 0.0949394544410782 no 338 0.0982706984753245 518 3784940 SGTC_1568 digitonin 820 nM 1.28838579284023 0.0954661856469231 no 339 0.0988058508858371 610 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1173 0443-0020 122 µM 1.28524974685947 0.0960042980794949 no 340 0.0993525123923312 551 5331295 SGTC_1643 st009866 20.2 µM 1.2836004283524 0.0962881971577415 no 341 0.0996408999013486 522 3156273 YOR207C RET1 SGTC_24 0417-1663 219 µM 1.28214140826274 0.0965398538897562 no 342 0.0998965227077529 539 4329390 SGTC_1289 0976-0073 69.1 µM 1.27692638960814 0.0974433081411588 no 343 0.100814118182455 590 3391136 SGTC_1552 6-methylflavone 10.6 µM 1.27609945640115 0.0975871345528917 no 344 0.100960181876882 495 689013 SGTC_447 ml7 120 µM 1.27503244102524 0.0977729478025916 no 345 0.101148879888186 563 4216 Selective myosin light chain kinase inhibitor. SGTC_1548 st061468 90.8 µM 1.27168870755276 0.0983569152799278 no 346 0.101741872208321 575 390799 SGTC_1374 2889-5571 141 µM 1.26975464643542 0.0986958538997943 no 347 0.102086020295061 604 2853281 SGTC_1185 1319-0113 81.3 µM 1.26893155435601 0.0988403574342347 no 348 0.102232738475647 501 4672763 SGTC_2371 9071574 200 µM 1.26770140862728 0.0990566125333285 no 349 0.102452300788255 499 45596039 SGTC_2323 6148992 148.28 µM 1.26698015561801 0.0991835669952169 no 350 0.102581192826488 499 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1581 himbacine 57.9 µM 1.26672987306505 0.0992276493559816 no 351 0.102625947288351 588 5281825 An alkaloid muscarinic receptor antagonist. SGTC_811 0416-0114 265 µM 1.26651757274469 0.0992650531205548 no 352 0.102663921053023 541 6612453 SGTC_3026 9090633 49.47 µM 1.26141527364835 0.100167096286127 no 353 0.103579634125445 572 25236842 SGTC_73 0327-0325 16.231 µM 1.26100295328817 0.100240251507225 no 354 0.103653891558227 658 53298 SGTC_3136 9095672 49.47 µM 1.26010841554123 0.100399097374928 no 355 0.103815127419638 504 17217380 SGTC_701 4424-0219 185 µM 1.25974120357011 0.100464357504637 no 356 0.103881368145399 643 2911779 SGTC_234 nsc-17383 10.7 µM 1.25818506964275 0.100741253813454 no 357 0.104162416633159 629 408974 SGTC_2029 5175081 200 µM 1.25632181702869 0.101073530067025 no 358 0.104499657494492 622 1380876 SGTC_1836 st055642 81 µM 1.2546818102927 0.101366654951268 no 359 0.104797145753132 581 8571 SGTC_2378 9074213 121.43 µM 1.24908999458286 0.102370757177884 no 360 0.105816079870331 601 657714 SGTC_922 1866-0035 480 µM 1.24592012413138 0.10294316180412 no 361 0.106396860587286 681 3156169 SGTC_1431 4049-0260 9.09 µM 1.24308575111091 0.103456949368144 no 362 0.106918117953335 584 3854841 SGTC_1690 st023502 41.2 µM 1.24279564573902 0.103509641662613 no 363 0.106971573739594 566 24207482 SGTC_1466 k213-0079 57.5 µM 1.24226064687873 0.103606865420652 no 364 0.107070204974223 592 3657981 SGTC_2653 dihydrofissinolide 100 µM 1.24002281981836 0.104014257395717 no 365 0.107483476899137 559 6857746 SGTC_1469 k284-2957 126 µM 1.23997303886014 0.104023333108687 no 366 0.107492683277831 566 23884841 SGTC_1004 4084-0029 199 µM 1.23949548811919 0.104110425966146 no 367 0.107581029317114 636 716894 YLR208W SEC13 SGTC_2818 7996756 12.99 µM 1.23759147463426 0.104458194164828 no 368 0.107933788586392 493 2241621 SGTC_983 1491-0821 12.2 µM 1.23637154883135 0.104681455653238 no 369 0.108160243345985 570 46495113 SGTC_2889 9059656 51.95 µM 1.23500451749737 0.104932049673337 no 370 0.108414411433073 632 3949838 SGTC_3115 9123671 49.47 µM 1.23434425937585 0.105053238696761 no 371 0.108537325062062 596 3286988 SGTC_1375 2910-0797 186 µM 1.23335983008993 0.105234116746072 no 372 0.108720772488466 594 742508 SGTC_962 1254-0300 21.5 µM 1.23327502439453 0.105249709395406 no 373 0.108736586371576 586 7340576 SGTC_2170 morpholine 200 µM 1.23268387347007 0.1053584467567 no 374 0.108846865388281 594 121171 Reacts with secondary amines. SGTC_890 0929-0006 47.2 µM 1.23177480858491 0.105525820322176 no 375 0.109016608024042 568 1378169 SGTC_3031 9088762 49.47 µM 1.2306591143029 0.105731500418525 no 376 0.109225192903692 613 205253 SGTC_1480 1070-0044 41.2 µM 1.22934888536527 0.105973413135982 no 377 0.109470512968799 601 3124987 SGTC_1233 0325-0408 14.2 µM 1.22899152357205 0.106039463616676 no 378 0.109537492057969 585 12874 SGTC_364 0083-0097 67.7 µM 1.2286582125984 0.106101095636572 no 379 0.109599989904457 598 5207356 SGTC_202 3594-0513 34.79 µM 1.22808238054442 0.106207632825313 no 380 0.109708022255212 564 708429 SGTC_192 3455-0609 60.9 µM 1.22173933224917 0.10738630433477 no 381 0.110903108625539 587 3769639 SGTC_3192 9110362 49.47 µM 1.22024783290252 0.107664820251363 no 382 0.111185469518172 620 16649480 SGTC_2706 st078239 82.5 µM 1.21962135037802 0.10778196187633 no 383 0.111304224471103 611 15434492 SGTC_2379 9035213 200 µM 1.21913610183142 0.107872758213286 no 384 0.11139626973543 654 646551 SGTC_1471 k673-0312 37 µM 1.21881439557368 0.107932984012434 no 385 0.111457323204757 578 24099884 SGTC_2091 4-phenylthiadiazole 200 µM 1.21786450506115 0.108110951857278 no 386 0.111637733324986 624 270010 SGTC_32 0928-0142 34.1 µM 1.21745152341114 0.108188392370019 no 387 0.111716234933202 566 2244242 SGTC_896 0964-0007 44.5 µM 1.21695460813252 0.108281624665737 no 388 0.111810743394318 628 6756758 SGTC_1965 Pectolinarigenin 58.4 µM 1.21649209860159 0.108368453625655 no 389 0.111898759584413 614 5320438 An anti-inflammatory. SGTC_2959 9079155 11 µM 1.21154697508703 0.109299956452258 no 390 0.112842921293146 532 16189457 SGTC_3113 9123498 49.47 µM 1.21002173192872 0.109588420729171 no 391 0.11313527700759 609 8897275 SGTC_525 k781-2675 26.7 µM 1.2098863058793 0.10961405981591 no 392 0.113161261316017 638 3651118 YDL195W SEC31 SGTC_931 2812-0076 566 µM 1.20623191568214 0.110307541952039 no 393 0.113864040566918 648 3450959 SGTC_1113 artemisinin 1.17947 µM 1.20577421013692 0.110394620512352 no 394 0.113952281049145 641 2240 An anti-malaria and mitochondrial poison. SGTC_2003 4023581 200 µM 1.20282087254526 0.110957678712944 no 395 0.1145228229105 599 16641307 SGTC_79 0052-0007 94.094 µM 1.20144077313856 0.111221500791871 no 396 0.114790133985171 628 2801472 SGTC_1824 st053723 68.6 µM 1.20106030281299 0.111294311036156 no 397 0.114863905171651 614 675225 SGTC_219 mitoxanthrone 164.414 µM 1.20068252532964 0.111366639707885 no 398 0.114937187591864 620 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2040 5100729 123 µM 1.19822698028783 0.111837594609985 no 399 0.115414332270085 636 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2009 4012297 12.05 µM 1.19629256965431 0.112209601619815 no 400 0.115791203674496 600 45595307 SGTC_229 benomyl 22.8748 µM 1.19446371441835 0.112562121783664 no 401 0.116148313215163 645 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.19411898313039 0.112628658817231 no 402 0.116215714278485 639 688664 SGTC_1909 st060837 51.5 µM 1.19323889482439 0.112798653185742 no 403 0.116387912975625 603 678937 SGTC_1208 2323-2347 50.3 µM 1.1901446385854 0.1133977814875 no 404 0.116994774022317 650 5412760 SGTC_1813 st051246 8.6015 µM 1.18920585761433 0.113580001788932 no 405 0.117179335030859 586 5291959 SGTC_835 0312-0010 67.2 µM 1.18788589215147 0.113836564168734 no 406 0.117439184292285 596 1626196 SGTC_1545 lovastatin 49.4 µM 1.18748093760181 0.11391535812438 no 407 0.117518985637397 662 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2905 7799065 20.05 µM 1.18300021421261 0.114789788739505 no 408 0.118404531259521 603 1296806 SGTC_2764 methyldopa 94.69 µM 1.18275176878985 0.114838413182055 no 409 0.118453770302086 669 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2167 5876490 200 µM 1.18114280873064 0.115153665177135 no 410 0.118772998160097 640 686534 SGTC_627 1391-0720 175 µM 1.18065331815448 0.115249695593452 no 411 0.118870236644426 625 997839 SGTC_825 1988-2224 89.6 µM 1.18064907795649 0.115250527702792 no 412 0.118871079215555 668 1180859 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.17988327954348 0.115400880354318 no 413 0.119023320447756 668 442882 SGTC_1354 1498-1681 81 µM 1.17934639288927 0.115506372816457 no 414 0.119130135931039 674 5754243 SGTC_1221 2958-7315 257 µM 1.17818469466426 0.115734868532229 no 415 0.119361491453508 626 4562705 SGTC_524 r073-0010 27.8 µM 1.17775438848074 0.115819587362681 no 416 0.119447268578232 633 2772106 SGTC_1079 idarubicin 2.36 µM 1.1772201737692 0.115924825002679 no 417 0.119553819303194 620 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2963 9082507 9 µM 1.17642588936146 0.116081420565359 no 418 0.119712365632069 600 16459611 SGTC_2404 5161160 200 µM 1.17240465730917 0.116876522884577 no 419 0.120517315275346 674 2831543 SGTC_1255 0566-0045 221 µM 1.1706703357814 0.117220632186694 no 420 0.120865656672852 650 2788469 SGTC_2197 6588183 93.1375 µM 1.17050247330208 0.117253976082677 no 421 0.12089940970554 591 884136 SGTC_2721 ifenprodil 61.44 µM 1.16973046723033 0.117407412455241 no 422 0.12105472661611 639 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1117 retinoic acid 1.10837 µM 1.1690915827432 0.117534498360813 no 423 0.121183367421611 703 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2698 st077697 67.5 µM 1.16868734190091 0.117614959606823 no 424 0.121264811858058 606 3154499 SGTC_982 1491-0518 27.5 µM 1.16786620037163 0.11777852197576 no 425 0.121430369868737 596 3091256 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.1673624988642 0.117878933398211 no 426 0.121532004433475 727 65057 A dermal irritant. YDR527W RBA50 SGTC_1708 st033234 31.827 µM 1.16715816498616 0.117919684023275 no 427 0.12157325102333 684 674664 SGTC_55 0767-0285 6.563 µM 1.16654111012546 0.118042804730122 no 428 0.121697868688256 685 3116166 SGTC_1136 pergolide 1.05886 µM 1.16081931319487 0.119188804480331 no 429 0.122857693578639 747 47811 A dopamine receptor agonist. SGTC_3097 9117246 49.47 µM 1.16075354150879 0.119202023170905 no 430 0.122871070599115 637 16423892 SGTC_2962 9082311 13.18 µM 1.160730208446 0.119206712862021 no 431 0.122875816455868 610 16459453 SGTC_1062 mesoridazine 14.2 µM 1.16035955816618 0.119281226991679 no 432 0.122951222560253 666 4078 A neuroleptic. SGTC_1239 0337-0584 35.4 µM 1.15996085259729 0.11936141794281 no 433 0.123032372523408 704 914301 YML130C ERO1 SGTC_2064 5220758 200 µM 1.15962594944399 0.119428805818338 no 434 0.123100565562756 698 788518 SGTC_1366 1683-0113 21.9 µM 1.15933030719061 0.119488316076241 no 435 0.12316078630346 609 708623 SGTC_1299 1079-1439 3.74 µM 1.15549746385107 0.120261728860429 no 436 0.123943385291358 626 323161 SGTC_3041 9091929 49.47 µM 1.15414706150067 0.120535059047961 no 437 0.124219940958168 683 25236887 SGTC_1478 0453-0656 35.7 µM 1.15144644265205 0.121082993308069 no 438 0.124774308344887 658 5258496 SGTC_2516 gossypol 71.55 µM 1.15024937302042 0.121326428936017 no 439 0.125020588051394 704 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2434 5670830 169.91 µM 1.1486685214636 0.121648437355325 no 440 0.125346345312245 655 1549830 SGTC_1415 3966-0071 78.1 µM 1.14769489851562 0.121847056154986 no 441 0.125547268959485 649 2893185 SGTC_3147 9097027 49.47 µM 1.1467053258522 0.122049162025917 no 442 0.125751714294196 700 25236841 SGTC_792 4534-1957 155 µM 1.14513828343849 0.122369689083106 no 443 0.12607593952026 669 1717904 SGTC_1159 4092-0538 61.2 µM 1.14413485261045 0.122575243531299 no 444 0.126283857833662 708 717301 SGTC_3189 9110682 49.47 µM 1.14221452060552 0.122969301837447 no 445 0.126682430846733 659 17122418 SGTC_350 k064-0020 19.8 µM 1.14208479050269 0.122995954862678 no 446 0.126709388431856 721 2790705 SGTC_1143 3454-2408 5.08 µM 1.14129208684997 0.123158903659542 no 447 0.126874197011491 622 X1143 SGTC_816 0325-0417 81.3 µM 1.13874146313785 0.123684238308454 no 448 0.127405501682786 646 68101 SGTC_759 3486-0358 89.3 µM 1.13614101197882 0.124221448794169 no 449 0.127948776606388 729 875103 SGTC_2781 5567276 71.43 µM 1.13516560718213 0.124423371711186 no 450 0.128152968420929 641 2853274 SGTC_2620 irigenin 100 µM 1.13472708208089 0.124514227504705 no 451 0.128244843233741 686 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1674 st016616 23.6 µM 1.13440085875407 0.124581846142906 no 452 0.128313219512657 662 625830 SGTC_1227 3909-8010 46.6 µM 1.13437058159271 0.124588123207856 no 453 0.128319566877005 663 15982272 SGTC_4 0960-0234 25.671 µM 1.13355819701 0.124756629438237 no 454 0.128489958202882 626 6821112 SGTC_1686 st019653 115.5 µM 1.13348727381117 0.124771348007706 no 455 0.128504841240596 667 97252 SGTC_2496 diffractaic acid 79.83 µM 1.13309471896305 0.124852836185865 no 456 0.128587239432623 704 94870 An apoptosis inducer which activates caspases. SGTC_455 paf C-16 10 µM 1.13290286437622 0.124892675688861 no 457 0.128627523500837 653 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1312 1218-2183 165 µM 1.13104089058277 0.125279784671061 no 458 0.129018940593688 707 6744073 SGTC_2708 st078559 56 µM 1.12920658517109 0.125661959685355 no 459 0.1294053482207 563 17250902 SGTC_399 oxolinic acid 75 µM 1.12907747276275 0.12568889068692 no 460 0.129432576715109 661 4628 A DNA gyrase inhibitor. SGTC_488 nitrendipine 139 µM 1.12535888197771 0.126466264035858 no 461 0.130218493776728 711 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2457 5731572 11.68 µM 1.12239186872102 0.127088917545299 no 462 0.130847930117655 690 2865357 SGTC_62 0180-0423 3.232 µM 1.12160951563067 0.12725345596131 no 463 0.131014251982788 662 30102 YGL099W LSG1 SGTC_2327 6189656 200 µM 1.12100958126356 0.127379729841234 no 464 0.131141892031113 677 5349088 SGTC_804 1595-0054 20.9 µM 1.1169902126927 0.128227972291545 no 465 0.131999254987948 638 761523 Stimulates phospholipase C. SGTC_1283 0922-0125 16.4 µM 1.11686951418555 0.128253504873275 no 466 0.132025060576185 733 3360884 SGTC_2966 9084041 48.03 µM 1.11532091724333 0.12858140856674 no 467 0.132356462472622 644 17741380 SGTC_1905 st060207 84.5 µM 1.11347877087527 0.128972226246086 no 468 0.132751430441405 695 1948547 SGTC_1120 ficusin 1.78878 µM 1.11249493223962 0.129181288120472 no 469 0.132962703942111 707 6199 A DNA cross-linker. SGTC_408 cantharidin 100 µM 1.11131108795412 0.129433161685308 no 470 0.133217234174396 724 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3235 9132602 49.47 µM 1.11099304824958 0.129500885455092 no 471 0.133285670806653 723 4912240 SGTC_2992 9074591 71.4286 µM 1.11037409231726 0.129632757073566 no 472 0.133418928733831 673 17741321 SGTC_2432 5630864 12.22 µM 1.10898651742316 0.12992872466354 no 473 0.133717999169889 679 5714970 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.10619192482182 0.130526225960435 no 474 0.134321728648412 505 4000243 SGTC_1142 3253-1408 9.78 µM 1.10580111618764 0.130609934478096 no 475 0.134406305899439 687 256655 SGTC_1172 0370-0043 85 µM 1.1051626067805 0.130746778643853 no 476 0.134544568227143 686 376585 SGTC_2098 5376439 882.5 nM 1.10278455734249 0.131257309604059 no 477 0.135060367946924 735 2844116 SGTC_1412 3909-8563 178 µM 1.10254261659166 0.131309327646883 no 478 0.135112920876241 774 23767530 SGTC_1816 st051957 91.6 µM 1.09986209585679 0.131886600882846 no 479 0.135696105942882 714 674121 SGTC_298 1391-0729 10 µM 1.09781585925813 0.13232845217912 no 480 0.136142452432577 684 3237558 SGTC_993 3909-8757 62.7 µM 1.09676922829978 0.132554848965237 no 481 0.136371142503827 659 4288324 YLR208W SEC13 SGTC_3255 9139072 49.47 µM 1.0938036462894 0.133197782866284 no 482 0.137020552294351 702 17646060 SGTC_1583 clindamycin 39.6 µM 1.09308127724555 0.13335471591215 no 483 0.13717905781318 642 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1452 4194-0072 190 µM 1.08942509943155 0.134150963158454 no 484 0.137983233997712 782 1343545 SGTC_2997 9067075 71.4286 µM 1.08755091745562 0.134560388629387 no 485 0.138396704421454 742 27209819 SGTC_1699 st031318 29.054 µM 1.08570624849339 0.134964203583022 no 486 0.138804487666 729 5340658 SGTC_894 0960-0238 55.9 µM 1.08518684894831 0.135078054723926 no 487 0.138919453821735 738 6741907 YDL195W SEC31 SGTC_3163 9099914 49.47 µM 1.08247989949879 0.135672477532188 no 488 0.139519671114371 685 16268368 SGTC_1943 st076331 65.2 µM 1.08156373108946 0.135874065478612 no 489 0.139723213866937 751 24208415 SGTC_1873 rapamycin 2 nM 1.0797287911181 0.136278430666882 no 490 0.140131484538981 763 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2376 9072922 81.32 µM 1.07836071349745 0.136580448833303 no 491 0.14043640608815 737 17087968 SGTC_3038 9091290 49.47 µM 1.07771510823312 0.136723132139366 no 492 0.140580457011592 710 25236843 SGTC_1190 1486-1332 13 µM 1.07585305008763 0.137135230775864 no 493 0.140996491099109 721 4150046 SGTC_714 4296-0578 26.1 µM 1.0754681874261 0.137220511791844 no 494 0.141082583842934 690 1589775 SGTC_2734 clemastine 41.6 µM 1.07373169191702 0.137605749070941 no 495 0.141471476460087 606 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.07288153172908 0.137794623952032 no 496 0.141662136647112 554 6708630 An antioxidant. SGTC_463 ikarugamyin 104 µM 1.07211460877418 0.137965158217869 no 497 0.141834278998957 683 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3186 9110464 49.47 µM 1.07113726950925 0.138182689549044 no 498 0.142053856278082 723 17018021 SGTC_530 4358-1714 28 µM 1.07009325087114 0.138415320248043 no 499 0.142288668367937 782 1564641 SGTC_526 4469-0568 170 µM 1.06903718031793 0.138650907787673 no 500 0.142526458116079 710 2901964 SGTC_144 4161-2749 112.381 µM 1.06726913703465 0.139045932906762 no 501 0.14292516025709 656 797501 YMR168C CEP3 SGTC_411 enrofloxacin 100 µM 1.06683432877186 0.139143197212632 no 502 0.143023326944552 744 71188 A bacterial gyrase inhibitor. SGTC_1056 3448-1962 115 µM 1.06678037368521 0.139155269908617 no 503 0.143035511564255 699 715507 SGTC_1925 st057770 10.1 µM 1.06606978728389 0.139314333368124 no 504 0.143196047977403 662 5989122 SGTC_499 genistein 192 µM 1.06181879876083 0.140268492586859 no 505 0.144158976962218 718 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2630 antimycin a 100 µM 1.06006169319524 0.140664178637114 no 506 0.144558266794316 784 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2924 9010168 62.78 µM 1.05877834854795 0.140953655785385 no 507 0.144850368205201 737 2993929 SGTC_2146 5545642 200 µM 1.05864058562725 0.140984754225743 no 508 0.144881747957097 747 825326 SGTC_3091 9116372 49.47 µM 1.05853718639539 0.141008098504273 no 509 0.144905303326281 691 17169793 SGTC_1087 pterostilbene 9.05 µM 1.05750460559046 0.141241366426843 no 510 0.145140676904656 769 5281727 Similar to reservatol, lowers cholesterol. SGTC_996 3970-0799 1.8 µM 1.05669439398237 0.141424582512806 no 511 0.145325542167705 931 6615648 YGL040C HEM2 SGTC_1857 st056007 79.3 µM 1.05570301279391 0.141648986160325 no 512 0.145551960141264 721 619834 SGTC_279 1273-0055 2.93 µM 1.05458469917177 0.14190241090746 no 513 0.145807652328999 806 2847562 SGTC_3187 9109394 49.47 µM 1.05219943022006 0.142443969779758 no 514 0.146354030434383 752 17098090 SGTC_2724 maprotiline 69.64 µM 1.05212514306047 0.142460858585215 no 515 0.146371068957506 770 4011 A tricyclic antidepressant. SGTC_3256 9138902 49.47 µM 1.04922600349833 0.143121021054843 no 516 0.1470370566511 788 17228773 SGTC_857 0438-0306 1.35 µM 1.0489190306892 0.143191042571229 no 517 0.147107692943438 745 4686136 SGTC_2124 5246320 200 µM 1.04713932906353 0.143597454338695 no 518 0.147517661269025 731 579342 SGTC_1195 1502-0147 41.1 µM 1.04544529809245 0.143985024960403 no 519 0.147908605075911 783 817940 SGTC_756 0508-1999 28.3 µM 1.0450759989713 0.144069609018462 no 520 0.147993922909161 730 6753853 SGTC_570 0987-0065 62.6 µM 1.04502712155186 0.144080806384804 no 521 0.148005217349561 659 3104428 SGTC_711 k292-0785 179 µM 1.04468621552898 0.144158921133469 no 522 0.148084008885953 754 4146315 SGTC_2395 5646831 180.19 µM 1.04365753828509 0.144394803906342 no 523 0.14832193092267 762 6808628 SGTC_103 0844-0104 51.839 µM 1.04167897225369 0.144849233653179 no 524 0.148780270603527 862 5375804 SGTC_2353 9059630 146.67 µM 1.0412977702361 0.144936897246732 no 525 0.148868685628246 760 4779114 SGTC_1153 4055-0057 267 µM 1.03956962322243 0.145334760648093 no 526 0.149269947941625 775 882706 SGTC_1939 st074455 53.6 µM 1.03783117082745 0.145735737264383 no 527 0.149674331078679 784 1644229 SGTC_648 0375-0473 33.3 µM 1.03781760585514 0.145738868966515 no 528 0.149677489311512 792 1713139 SGTC_2451 5856223 45.7 µM 1.03781388134627 0.14573972883998 no 529 0.149678356469325 745 2179896 SGTC_1655 st012546 55.1 µM 1.03651329147441 0.146040203195836 no 530 0.149981370923455 741 720985 YLR208W SEC13 SGTC_801 0866-0028 10.1 µM 1.0359223237347 0.146176871478526 no 531 0.150119191025375 795 6849771 SGTC_981 1488-1094 54.9 µM 1.03175396837184 0.147143292377415 no 532 0.151093694125417 709 3449522 SGTC_1459 k035-0031 35.7 µM 1.03108396149758 0.147299030179615 no 533 0.151250724130111 683 3877128 YMR208W ERG12 SGTC_1621 st003705 32.4 µM 1.02588979466734 0.14851012044954 no 534 0.152471766792542 821 24207032 SGTC_181 1447-1644 8.07 µM 1.02453938195894 0.14882607494712 no 535 0.15279028974265 783 534600 SGTC_448 monastrol 171 µM 1.02292935066625 0.149203358748009 no 536 0.153170625463969 783 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_422 cantharidin 155 µM 1.02168557039299 0.149495254691244 no 537 0.153464871368074 770 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1685 st024049 53.0905 µM 1.0212887384782 0.149588465134075 no 538 0.153558830156614 752 1941139 SGTC_2517 totarol 10 µM 1.02021939517353 0.149839832415046 no 539 0.15381221058818 714 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3112 9123419 49.47 µM 1.01986208993312 0.14992388583096 no 540 0.15389693555623 812 17015854 SGTC_844 0330-0132 15.3 µM 1.01913597233924 0.150094796486532 no 541 0.154069209224535 836 2828079 SGTC_1140 3229-1848 2.98 µM 1.01635223296094 0.150751225023029 no 542 0.15473084178159 801 2849525 SGTC_519 k048-0011 62.8 µM 1.01433492339457 0.151228115871602 no 543 0.155211482568313 778 6836379 SGTC_2515 chrysin 20.77 µM 1.01206965854282 0.151764818093753 no 544 0.155752374225434 798 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.01197257370489 0.151787848356411 no 545 0.155775583531253 857 1377 SGTC_583 1488-1091 88.9 µM 1.00979431427694 0.152305181081118 no 546 0.156296922379978 935 4303273 SGTC_1485 3909-9022 254 µM 1.00915773488089 0.152456588304282 no 547 0.156449496375321 812 714516 SGTC_1348 1493-0373 93.8 µM 1.00814308256669 0.152698124700544 no 548 0.156692888768869 789 3010129 SGTC_2139 5578692 56.4705 µM 1.00812333223491 0.152702828753268 no 549 0.156697628903201 743 650991 YMR113W FOL3 SGTC_1892 st058411 7.36 µM 1.00757574080239 0.152833290105106 no 550 0.156829089948024 855 3934738 SGTC_1457 k015-0032 57.3 µM 1.00696142436576 0.152979736356138 no 551 0.156976656110266 790 4302660 SGTC_126 0417-1624 672.48 µM 1.00537632447999 0.153358036236838 no 552 0.157357837850509 952 41912 YDL195W SEC31 SGTC_2890 9046729 58.44 µM 1.00296591665337 0.153934490870361 no 553 0.157938653195708 731 903329 SGTC_1392 3455-1037 33.9 µM 1.00288959366298 0.153952767080367 no 554 0.157957067055568 788 981132 SGTC_1752 st044819 83.042 µM 1.001806379357 0.154212307049052 no 555 0.158218557785483 755 441209 YML126C ERG13 SGTC_329 k048-0121 21.3 µM 0.994332108508889 0.156011038337589 no 556 0.160030604375255 783 6832902 SGTC_1728 st035614 33.7865 µM 0.9941046881368 0.15606598441147 no 557 0.160085951600084 867 15945546 SGTC_827 3253-0474 693 µM 0.992561371753771 0.156439195437068 no 558 0.160461878641856 848 5402065 SGTC_1524 corynanthine 62.1 µM 0.989782936209843 0.157112568266917 no 559 0.161140113506526 796 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1138 3761-0006 1.03 µM 0.989604614610763 0.15715585072445 no 560 0.161183706796496 819 12061087 SGTC_1091 telmisartan 47.6 µM 0.988691015817267 0.157377723632121 no 561 0.161407169893014 837 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.98713032646296 0.157757222408563 no 562 0.161789376230668 790 279621 SGTC_433 pimozide 108 µM 0.985984241381955 0.158036288052023 no 563 0.162070422963449 680 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3064 1327-0027 10 µM 0.985075108538594 0.158257887437495 no 564 0.162293589506267 665 16000455 YPR107C YTH1 SGTC_193 1273-0060 1.558 µM 0.984689753341671 0.158351878527095 no 565 0.16238824370749 710 2847393 YHR072W ERG7 SGTC_2626 ethyl orsellinate 100 µM 0.982338687013135 0.158926114813889 no 566 0.162966510655409 779 75653 A natural product. SGTC_166 k072-0058 166.424 µM 0.982193688445496 0.158961574615445 no 567 0.16300221819641 824 5846229 SGTC_1671 st016596 74.5 µM 0.979844722795985 0.159536742916647 no 568 0.163581386131211 871 2829167 SGTC_2718 lomofungin 53.02 µM 0.979667127859611 0.15958028417501 no 569 0.163625228731273 793 5351222 A RNA synthesis inhibitor. SGTC_2399 5884133 200 µM 0.979323436176737 0.159664569748613 no 570 0.163710097057113 780 722445 SGTC_1608 st001473 40.5 µM 0.977989287775899 0.159992026937119 no 571 0.164039811116303 783 7292267 SGTC_1219 1469-0211 33.1 µM 0.975995510132905 0.160482203408539 no 572 0.164533344654637 814 6822282 SGTC_3294 9122953 26.2835 µM 0.97287089160804 0.161252372258147 no 573 0.165308736801596 835 16459826 SGTC_2797 7859098 81.82 µM 0.969933438467632 0.161978602940746 no 574 0.166039835573518 819 972681 SGTC_1493 4348-0038 111 µM 0.969056307997401 0.162195869578968 no 575 0.166258547850078 888 800424 SGTC_3180 9109287 49.47 µM 0.967320343679403 0.162626429888671 no 576 0.16669195842237 787 18891271 SGTC_1009 4106-0057 9.87 µM 0.967221166989412 0.162651050492284 no 577 0.166716741426886 898 2928005 SGTC_484 loperamide 105 µM 0.964417791400461 0.163347991086923 no 578 0.167418252966366 755 3955 An opioid-receptor agonist. SGTC_2280 7785178 200 µM 0.962915604544237 0.163722243326955 no 579 0.167794938961872 818 2954328 SGTC_1209 2323-2347 50.3 µM 0.962456162433423 0.163836819007935 no 580 0.167910256827217 846 5412760 SGTC_2981 9013952 38.96 µM 0.960549510176406 0.164312855902575 no 581 0.168389362814819 752 2996344 SGTC_296 1222-0039 74.9 µM 0.957371933608298 0.165108197140179 no 582 0.169189779700984 792 5984176 SGTC_1649 st011737 51.3 µM 0.95648590938743 0.165330410876517 no 583 0.169413399944389 831 1761035 SGTC_2251 lansoprazole 556 µM 0.955329335220717 0.165620769228021 no 584 0.169705588514162 683 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3263 9137018 49.47 µM 0.953953556877126 0.165966588040884 no 585 0.170053575900359 791 43844957 SGTC_2405 ticlatone 3.52 µM 0.951580489451989 0.166564183523958 no 586 0.170654890113084 866 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3094 9117742 49.47 µM 0.943641868967804 0.168573399674416 no 587 0.172676344494207 930 17149698 SGTC_354 2783-3500 4.88 µM 0.942727161714679 0.168805903423948 no 588 0.172910238260039 826 6740761 SGTC_2795 7780010 54.55 µM 0.942591437775201 0.168840419795437 no 589 0.172944960526122 810 953673 SGTC_2143 5623677 140.463 µM 0.941684070078084 0.16907129174213 no 590 0.173177206596199 845 5375313 SGTC_560 2332-1943 155 µM 0.941601685140945 0.16909226391951 no 591 0.173198303334186 854 21177716 SGTC_1697 st025554 27.742 µM 0.941575424967062 0.169098949145836 no 592 0.173205028257039 834 1269519 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.932488589402611 0.171422433022097 no 593 0.175542040468393 934 676296 Flavone; oxidizing agent. SGTC_1089 terbinafine 2.25 µM 0.932471067910868 0.171426932849148 no 594 0.175546565978848 875 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_719 2810-4230 27.3 µM 0.932196620977679 0.17149742549778 no 595 0.175617460715047 851 721079 SGTC_3220 9131269 49.47 µM 0.930565606574157 0.171916739310671 no 596 0.176039156217845 857 17722206 SGTC_2810 7959871 45.46 µM 0.930200610397549 0.17201066491712 no 597 0.176133612960522 910 2974535 SGTC_1724 st037281 8.293 µM 0.929328005538437 0.172235347800185 no 598 0.176359562897634 845 574124 YDL195W SEC31 SGTC_1093 fluphenazine 7.97 µM 0.927672466121891 0.17266213921471 no 599 0.176788747559364 900 6602611 An atypical antipsychotic. SGTC_543 3844-1095 191 µM 0.926906111803354 0.172859930374932 no 600 0.176987641828028 901 4230703 SGTC_3249 9135183 49.47 µM 0.926665446504481 0.172922074333826 no 601 0.177050131587389 916 4902779 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.926501606545133 0.172964388799554 no 602 0.177092681297605 955 5024745 SGTC_2893 9048488 25.97 µM 0.925207747919269 0.173298781605157 no 603 0.177428927027174 859 6467338 SGTC_1659 st012954 42.1 µM 0.924144968924379 0.173573760463936 no 604 0.177705421470921 866 24207262 SGTC_2961 9083290 32.55 µM 0.92388123727599 0.173642040229532 no 605 0.177774076436529 841 17741490 SGTC_845 0330-0138 4.51 µM 0.922353250773358 0.174037970124079 no 606 0.178172173106686 908 9039800 SGTC_1555 citronellol 128 µM 0.921798996376463 0.174181729548198 no 607 0.17831671553089 849 8842 A terpine precursor. SGTC_1433 4060-0023 7.6 µM 0.918803894864892 0.174959887637437 no 608 0.179099077443895 900 3840627 SGTC_2903 5923464 63.88 µM 0.916702312684592 0.175507215093736 no 609 0.179649326946933 878 2876576 SGTC_2675 theaflavin digallate 100 µM 0.916598239438375 0.175534347675698 no 610 0.179676603638377 905 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.915107320193893 0.175923331954474 no 611 0.180067646215138 949 6708561 SGTC_1847 st056231 15 µM 0.914200114517582 0.176160290939053 no 612 0.180305851999382 944 5393180 SGTC_2233 sulbentine 40.3845 µM 0.912743459288633 0.176541186632931 no 613 0.180688740661249 933 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1956 st077085 54 µM 0.912387952186693 0.176634225961415 no 614 0.180782264709955 911 24208685 SGTC_2350 9023895 38.85 µM 0.907939587687081 0.177801022148921 no 615 0.181955070256788 883 2997209 SGTC_3012 9080433 71.4286 µM 0.906651665066419 0.178139746973013 no 616 0.18229551560408 961 17688859 SGTC_1163 k060-0048 49.9 µM 0.905971146958677 0.178318887995325 no 617 0.18247556220515 925 6809982 SGTC_2316 5844804 197.44 µM 0.905412994005932 0.178465902059274 no 618 0.182623317196021 1036 776813 SGTC_3154 9100113 49.47 µM 0.905342260624707 0.178484538247488 no 619 0.182642047163073 895 25237525 SGTC_315 k915-0449 187 µM 0.904490515555119 0.178709044542308 no 620 0.182867680638942 985 20970215 YNL149C PGA2 SGTC_2804 7954240 19.48 µM 0.901970736307485 0.179374258273583 no 621 0.183536206588103 921 828705 SGTC_438 sphingosine 6.67 µM 0.900751753851545 0.179696623798798 no 622 0.183860162407084 828 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_550 4123-0385 25.7 µM 0.899743679885894 0.179963488410857 no 623 0.184128336215044 898 5731123 SGTC_2808 7946468 45.46 µM 0.899464836715168 0.180037349705549 no 624 0.184202558694884 911 2970879 SGTC_2117 5521686 200 µM 0.897959337259327 0.180436462226773 no 625 0.18460361415708 881 803312 SGTC_2229 7354935 190 µM 0.897183172853581 0.180642442465058 no 626 0.18481059137809 879 318112 SGTC_3078 9116413 49.47 µM 0.8967736973425 0.180751169377866 no 627 0.18491984297036 910 17177322 SGTC_664 1222-0054 14.9 µM 0.896472203548314 0.180831250419963 no 628 0.185000309759436 913 6813991 SGTC_1011 4112-3381 17.4 µM 0.895804813927824 0.181008597687527 no 629 0.185178509197879 900 2877139 SGTC_1819 st053448 58.6 µM 0.89514601036386 0.181183770208658 no 630 0.185354520597657 909 2857616 SGTC_1130 3454-2858 15.9 µM 0.894899699814542 0.181249290194347 no 631 0.185420353624895 862 715628 YIL048W NEO1 SGTC_302 1094-0063 18.9 µM 0.894881288382693 0.181254188334305 no 632 0.185425275151345 847 5440289 SGTC_757 1066-0008 322 µM 0.894696199394792 0.181303433638457 no 633 0.185474755457923 932 6842497 SGTC_2982 9019404 25.97 µM 0.894480007247015 0.181360964945433 no 634 0.18553256102657 832 22333232 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.892018516888289 0.182016802608752 no 635 0.186191503723436 982 16623 A steroid. SGTC_319 1348-1596 45.5 µM 0.891801380686057 0.182074727306413 no 636 0.18624970076986 950 5380505 SGTC_3123 9126162 49.47 µM 0.890987231384654 0.182292017788707 no 637 0.186468010169905 906 25239884 SGTC_1560 lithocholic acid 53.1 µM 0.890641525449201 0.182384333162216 no 638 0.186560757123307 868 9903 A bile acid which acts as a detergent. SGTC_1578 josamycin 24.2 µM 0.88947040612478 0.182697279311843 no 639 0.186875160531813 844 5282165 A P450 substrate. SGTC_1782 st039423 80.636 µM 0.8892871919256 0.182746268064668 no 640 0.186924376596986 848 2068169 SGTC_2053 5265679 138 µM 0.885550217349613 0.183747268388608 no 641 0.187929973915404 930 764595 SGTC_1747 st037496 66.6 µM 0.883973470398334 0.184170644573151 no 642 0.188355267108041 934 723305 SGTC_1080 nisoldipine 24.4 µM 0.883014277193527 0.184428496675596 no 643 0.188614278816044 935 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1613 st002381 52.1 µM 0.881517442518412 0.184831326974079 no 644 0.189018908732665 990 551167 SGTC_1844 rapamycin 4 nM 0.880934504239221 0.184988356009587 no 645 0.189176635334914 982 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_893 0958-0369 48.9 µM 0.880839768604877 0.185013883254881 no 646 0.189202275770212 958 6819948 SGTC_1947 st076332 61.6 µM 0.880169120036325 0.18519465725031 no 647 0.189383849660753 925 24208416 SGTC_1633 st005664 67.9 µM 0.879816343733198 0.185289792470623 no 648 0.189479404662422 961 2063822 SGTC_635 k038-0028 24.7 µM 0.878233039299203 0.18571714493147 no 649 0.189908632812053 936 4035102 SGTC_3054 9094397 49.47 µM 0.878098440765928 0.185753502834713 no 650 0.189945149539922 981 2598354 SGTC_730 1436-0052 41.2 µM 0.877018049757594 0.186045499170652 no 651 0.190238417144399 913 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2172 5754775 163.918 µM 0.875802340615072 0.186374407857065 no 652 0.190568748705053 850 2263357 SGTC_311 1315-0136 58 µM 0.875718608065957 0.186397074852127 no 653 0.190591513403964 933 6759207 SGTC_3033 9090887 49.47 µM 0.872911403319765 0.187157993187673 no 654 0.191355685132778 965 19325384 SGTC_870 0573-2213 57.6 µM 0.8726049834879 0.187241167199534 no 655 0.191439211653509 962 3916321 SGTC_3171 9103192 49.47 µM 0.867134275918486 0.188729970011557 no 656 0.192934221121075 1000 13018434 SGTC_2219 9098279 200 µM 0.864178062044346 0.189537504548953 no 657 0.193745040816866 962 902349 SGTC_1810 st050138 53 µM 0.864005886182263 0.189584602414784 no 658 0.193792328525645 942 3444541 SGTC_995 3931-2021 34.6 µM 0.86157372107854 0.190250678302385 no 659 0.194461068569228 914 730143 SGTC_1780 st038448 24.544 µM 0.861072100768711 0.190388231308273 no 660 0.194599166953996 955 728868 YDL195W SEC31 SGTC_1281 0884-0031 11.8 µM 0.859915499260583 0.190705624237336 no 661 0.19491781204373 959 1548255 SGTC_1926 methyl fluorone black 53.6 µM 0.85903378621676 0.19094780067128 no 662 0.19516093803304 878 72721 Reacts with homocysteine. SGTC_639 0833-0042 114 µM 0.858668929163609 0.191048069590279 no 663 0.195261598614691 980 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3321 9137793 26.8275 µM 0.857746168297576 0.191301804024748 no 664 0.195516320289223 960 4904192 SGTC_2987 9018338 71.43 µM 0.855664230160016 0.191875039314019 no 665 0.196091765519847 969 5055682 SGTC_1249 0481-0015 10.2 µM 0.851449355657864 0.193038766490646 no 666 0.197259892370379 947 4227577 SGTC_2884 9058502 51.95 µM 0.851431122752378 0.193043809940894 no 667 0.19726495463624 960 6471554 SGTC_1682 st012968 530 nM 0.851243132642577 0.1930958150534 no 668 0.19731715363782 873 24207270 SGTC_2952 9073731 13.78 µM 0.850503311802819 0.193300560289521 no 669 0.197522659978593 1021 16457353 SGTC_1468 k284-1086 134 µM 0.850492329787604 0.193303600557115 no 670 0.197525711520938 1018 15996457 SGTC_673 1082-0474 110 µM 0.850386300301899 0.193332955323628 no 671 0.197555175108318 1069 3098046 SGTC_375 3970-0961 9.27 µM 0.850075874062783 0.193418913940784 no 672 0.197641451960133 963 2898222 SGTC_1808 st050063 61.5 µM 0.845674135686114 0.194640285832073 no 673 0.198867277805596 968 4011993 SGTC_2174 5790901 200 µM 0.845607501554691 0.194658811115288 no 674 0.198885869672089 940 786020 SGTC_688 0527-0193 473 µM 0.843384606889351 0.195277423686095 no 675 0.199506689025771 939 4007154 SGTC_1346 1488-2224 62.4 µM 0.841519817450818 0.195797298874155 no 676 0.200028393864001 1002 3722427 SGTC_912 3474-0017 2.18 µM 0.840828661338554 0.195990195941023 no 677 0.2002219640434 995 3360550 SGTC_1238 0333-0287 48.8 µM 0.840371395338863 0.196117879180518 no 678 0.200350091117544 975 7226 SGTC_607 4491-0986 66.8 µM 0.840008180315923 0.196219336332291 no 679 0.200451899967389 1012 698981 YDR232W HEM1 SGTC_2912 7964298 10.93 µM 0.83939492994811 0.196390708273814 no 680 0.200623864008946 993 2975850 SGTC_2783 7738165 71.43 µM 0.838617464112428 0.19660810035443 no 681 0.200842003660654 893 17201110 SGTC_1665 st014639 11.4 µM 0.837168692820928 0.197013589094647 no 682 0.201248876265516 1045 981133 YIL048W NEO1 SGTC_1078 idebenone 36.1 µM 0.835783307485857 0.197401810148104 no 683 0.201638409424379 1012 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1761 st044296 37 µM 0.835593446155578 0.197455050259922 no 684 0.201691828499801 1023 1826700 SGTC_470 aa-861 153 µM 0.835434154767645 0.19749972477516 no 685 0.201736653004269 984 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3205 9113483 49.47 µM 0.834510084294989 0.197759008101393 no 686 0.201996803572939 988 17018033 SGTC_2231 micatex 6.853 µM 0.832704772587114 0.198266150461653 no 687 0.202505626107255 1012 20737 An antifungal of unknown mechanism. SGTC_2332 7982454 138.89 µM 0.832154545611469 0.1984208744017 no 688 0.202660858417451 994 2981748 SGTC_3247 9135149 49.47 µM 0.828479772652609 0.199456088170221 no 689 0.203699422792107 947 8934436 YOR116C RPO31 SGTC_365 0121-0052 13.6 µM 0.827870767731162 0.199627963382796 no 690 0.203871845776887 1015 3101739 SGTC_2998 9066762 71.4286 µM 0.827826360582409 0.199640499588034 no 691 0.203884421840684 997 4945196 SGTC_1888 azatryptophan 97.5 µM 0.827140205134003 0.199834262510574 no 692 0.204078799190537 905 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_486 niguldipine 82 µM 0.826011311234358 0.200153296036977 no 693 0.204398837687131 955 1236 A calcium channel blocker. SGTC_1519 esterone 74 µM 0.825184173317092 0.200387245358329 no 694 0.204633518674412 977 698 A steroid. SGTC_2345 9052315 157.45 µM 0.82332202592109 0.200914539644331 no 695 0.205162445686571 982 6469265 SGTC_3035 9091303 49.47 µM 0.823307442171341 0.200918672529263 no 696 0.205166591279267 1009 25237002 SGTC_393 acivicin 6.25 µM 0.822548137062691 0.201133922258081 no 697 0.2053825009372 926 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_266 formosanin C 406 nM 0.821690348115097 0.201377256723287 no 698 0.20562657690487 1013 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1352 1496-0991 99 µM 0.820531440578685 0.201706291506971 no 699 0.205956606706895 1033 3000039 SGTC_2907 7721985 69.9 µM 0.820068707801154 0.201837759600712 no 700 0.206088469916069 1028 3267881 SGTC_3173 9105693 49.47 µM 0.818716917695557 0.202222113611544 no 701 0.206473971055297 1059 17096658 SGTC_325 2810-4341 181 µM 0.81675696969382 0.202780161934257 no 702 0.207033663698355 1038 774970 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.815682618424929 0.203086447782231 no 703 0.207340841384453 1052 6728940 SGTC_2583 asiatic acid 100 µM 0.815606428794 0.203108179099901 no 704 0.207362635692755 1014 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2687 chenodiol 100 µM 0.815167809613984 0.203233312004568 no 705 0.207488130571653 975 5702181 A cholesterol synthesis inhibitor. SGTC_1522 st012842 45.6 µM 0.81453266169263 0.203414593788001 no 706 0.20766993452492 903 3491067 YOR116C RPO31 SGTC_344 k064-0035 6.43 µM 0.812579093111811 0.203972779137282 no 707 0.208229711166989 983 5088750 SGTC_3352 9151559 45.5865 µM 0.810490522854773 0.204570546288087 no 708 0.20882915486538 1007 17159339 SGTC_2821 7996764 71.43 µM 0.809962470121645 0.204721844547158 no 709 0.208980872955274 1086 2987135 SGTC_1941 st076221 61.8 µM 0.808994489104093 0.204999364326392 no 710 0.209259158082608 1049 2828568 SGTC_1234 0326-0494 15.5 µM 0.807552314691357 0.205413249712294 no 711 0.209674173534554 1039 1547813 SGTC_3279 9140807 49.47 µM 0.806482368869989 0.20572063072618 no 712 0.209982385038101 1065 45595718 SGTC_2601 securinine 100 µM 0.802666706529085 0.206819039496274 no 713 0.211083700592857 1002 442872 A GABA receptor antagonist. SGTC_948 3448-0295 75.3 µM 0.800862577785053 0.207339597758594 no 714 0.211605603313501 1044 678569 SGTC_1964 st076914 61 µM 0.800740114606448 0.207374960996411 no 715 0.211641057114567 1078 24208661 SGTC_851 0394-0702 453 µM 0.799397717295516 0.207762833806538 no 716 0.212029916825061 1088 762646 SGTC_2792 7535235 81.82 µM 0.798894765214827 0.207908267260987 no 717 0.212175717289362 987 1281891 SGTC_220 paclitaxel 373.376 µM 0.79788597747479 0.208200149118754 no 718 0.212468330749818 965 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3098 9119039 49.47 µM 0.797455228988952 0.208324855179121 no 719 0.212593347362332 1081 17161528 SGTC_2719 novobiocin 32.65 µM 0.795604286611982 0.208861223040536 no 720 0.213131037137849 1012 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_552 k242-0005 476 µM 0.792464182838037 0.209773024010468 no 721 0.214045034110645 1027 4088318 SGTC_392 N-ethylmaleimide 8.33 µM 0.7919997841839 0.209908071149164 no 722 0.214180401036042 1004 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_866 0495-0101 262 µM 0.791711781756718 0.209991847925535 no 723 0.214264375485782 980 635694 SGTC_2336 9001819 198.65 µM 0.791212332585665 0.210137178833378 no 724 0.214410048022318 1068 2989602 SGTC_2967 9089538 49.85 µM 0.790923206423753 0.210221336445699 no 725 0.214494402719713 1079 728216 SGTC_3295 9122362 53.5725 µM 0.789779628881376 0.210554398053888 no 726 0.214828238964357 1029 4730473 SGTC_177 1327-0068 8.361 µM 0.789357589347638 0.210677393280095 no 727 0.21495151809773 1038 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_942 3253-1115 227 µM 0.78922287118338 0.210716663146035 no 728 0.214990878364772 1058 46497897 SGTC_2458 5808907 16.39 µM 0.788471488662093 0.210935767228883 no 729 0.215210484663644 1128 2731747 SGTC_1039 k821-0043 94 µM 0.787835349214717 0.211121370662103 no 730 0.215396510645379 1073 15992768 SGTC_650 1328-0195 38 µM 0.787068830520584 0.211345141336793 no 731 0.215620787253459 1068 2780821 SGTC_1449 4112-4002 201 µM 0.786245337861633 0.211585699217674 no 732 0.215861884751315 1004 2059539 SGTC_516 3992-2719 87.3 µM 0.784841244333059 0.211996231113432 no 733 0.216273327343782 1062 5350887 YDR037W KRS1 SGTC_1268 0828-0275 2.46 µM 0.78182108479902 0.212880848935067 no 734 0.217159863932656 1096 745337 SGTC_178 4092-0806 87.505 µM 0.781466322709477 0.212984901498012 no 735 0.217264138284002 1047 2169044 SGTC_1237 0330-0133 46.1 µM 0.781155723073808 0.213076025468176 no 736 0.21735545581146 1015 X1237 YHR072W ERG7 SGTC_1680 diphenhydramine 100 µM 0.780537572787703 0.213257446553031 no 737 0.217537260382758 1010 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2173 5763948 167 µM 0.778890594252638 0.213741258178191 no 738 0.218022082518774 1115 2867177 SGTC_584 0986-0246 15.4 µM 0.777652378577406 0.214105413431663 no 739 0.218386986713534 1192 53315 YDR232W HEM1 SGTC_2125 5246583 200 µM 0.777268172216878 0.214218480641891 no 740 0.218500284431907 1124 835267 SGTC_2020 4017018 200 µM 0.777178343573987 0.214244921117119 no 741 0.218526778672095 1089 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.777131160195656 0.214258809997308 no 742 0.218540695773337 1108 94937 An inhibitor of serotonin biosynthesis. SGTC_620 0109-0052 432 µM 0.776812830076587 0.214352527208976 no 743 0.21863460303142 1090 493037 SGTC_2051 5263410 176 µM 0.774165954504087 0.215132696991727 no 744 0.219416329305239 1148 227584 SGTC_1684 st024538 14.6195 µM 0.771958337414881 0.215784653748268 no 745 0.220069551812186 1068 6732859 SGTC_2929 9013348 24.6 µM 0.771525284191127 0.215912677891046 no 746 0.220197820782708 1054 2995952 SGTC_20 0481-0013 4.944 µM 0.771443548473962 0.215936846474264 no 747 0.220222035447803 1084 182045 SGTC_2733 amorolfine 100 µM 0.770954144425858 0.21608159203735 no 748 0.220367056084582 1069 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2308 7584454 197.62 µM 0.770708226367053 0.216154345680564 no 749 0.220439947399409 1100 893577 SGTC_1679 SEC14.276 6.7 µM 0.770675606883789 0.216163997059089 no 750 0.220449617011632 1120 1005053 YMR079W SEC14 SGTC_523 1934-0222 13.7 µM 0.769573672165022 0.216490181577135 no 751 0.220776413695318 1088 1361595 SGTC_2002 4023503 131 µM 0.768877659677224 0.216696355427392 no 752 0.220982970405115 1159 4736863 YCR052W RSC6 SGTC_1331 1472-0049 76.2 µM 0.768245326682487 0.216883764454751 no 753 0.221170724710408 1074 24051409 SGTC_2090 5301565 104.445 µM 0.767706494702441 0.217043535834676 no 754 0.221330788394099 1104 2056344 SGTC_276 colchicine 750 µM 0.766204738044685 0.21748918690524 no 755 0.221777244807152 1125 2833 A microtubule depolymerizer. SGTC_1929 genistein trimethyl ether 50.5 µM 0.763664116204929 0.218244325961923 no 756 0.222533715025799 1131 136420 SGTC_1356 1502-0781 85.8 µM 0.763663156485354 0.218244611500756 no 757 0.222534001060039 1031 567702 SGTC_1266 0828-0227 32.9 µM 0.761324727091578 0.218940987468456 no 758 0.223231567420449 1055 3913820 SGTC_400 oxethazaine 37.5 µM 0.760574675133645 0.219164620717287 no 759 0.223455575409022 1041 4621 A local anesthetic. SGTC_2492 derrusnin 100 µM 0.758139695718092 0.219891531439143 no 760 0.22418367895865 1025 1715307 Part of coumarin class of compounds. SGTC_2445 5742597 35.57 µM 0.755693452883619 0.220623195908877 no 761 0.224916505183277 1053 1774255 SGTC_1029 k015-0030 64.7 µM 0.75343232217975 0.221300732499908 no 762 0.225595082942991 1069 2208316 SGTC_2972 9093619 59.92 µM 0.753430698070396 0.221301219583512 no 763 0.225595570763146 1095 25236256 SGTC_744 1594-0068 283 µM 0.752228686436862 0.221661880765884 no 764 0.225956772619693 1137 668392 SGTC_2676 harmalol 100 µM 0.752125794299989 0.221692768943329 no 765 0.22598770666573 1107 5459187 A monoamine oxidase inhibitor SGTC_2983 9022671 12.99 µM 0.751836025365909 0.221779770673428 no 766 0.22607483722258 1069 6405161 SGTC_693 4161-2696 114 µM 0.750595372770918 0.22215249110534 no 767 0.226448103383017 1092 805759 SGTC_2581 avocatin a 64 µM 0.749520626858949 0.222475658159926 no 768 0.226771735521549 1103 6710728 A skin care supplement. SGTC_2428 5615643 7.78 µM 0.749499714766427 0.222481948908095 no 769 0.226778035248554 1087 2253075 SGTC_2621 lithochol-11-enic acid 100 µM 0.74681848512537 0.223289352731535 no 770 0.227586567933681 1120 6708711 SGTC_469 w7 172 µM 0.746483193137052 0.223390437028658 no 771 0.227687790273941 1172 45115570 A P450 inhibitor. SGTC_2904 7225135 42.03 µM 0.746273431402026 0.223453689527579 no 772 0.227751128780644 1166 4446116 SGTC_989 1501-0895 10.3 µM 0.745781035091471 0.223602208954215 no 773 0.227899849034067 1125 2830112 SGTC_3307 9126885 69.2785 µM 0.744854724560316 0.223881760186579 no 774 0.228179774004679 1118 24824909 SGTC_1129 3453-1384 223 µM 0.744686442216247 0.223932567421923 no 775 0.228230648567144 1131 1084452 SGTC_359 0081-0058 15.9 µM 0.742862330765523 0.224483717213654 no 776 0.22878251690916 1112 3494159 SGTC_385 1494-0393 12.4 µM 0.742003589812807 0.224743449465564 no 777 0.229042580299634 1100 3090647 SGTC_2765 myclobutanil 7.74 µM 0.741672808905544 0.224843541928369 no 778 0.22914279909528 1126 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1116 jasmonic acid  1.58368 µM 0.741206079868676 0.224984814517783 no 779 0.2292842487853 1140 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1859 st055998 20 µM 0.740869121656286 0.225086838489868 no 780 0.229386399776604 1148 676301 SGTC_125 0133-0007 11.75 µM 0.740098934291764 0.225320133689482 no 781 0.229619982659637 1205 26541 SGTC_429 1112-0049 25.5 µM 0.739379429191639 0.225538200526063 no 782 0.22983831492233 1056 2836170 SGTC_2431 5490079 200 µM 0.737934699806747 0.225976428076132 no 783 0.230277065724869 1177 5722345 SGTC_1394 3474-0001 65.7 µM 0.736879863249633 0.226296693846874 no 784 0.230597705343149 1049 5017666 YIL048W NEO1 SGTC_743 1275-0778 158 µM 0.736508244546419 0.226409584460444 no 785 0.230710726014794 1130 2849257 YMR203W TOM40 SGTC_3260 9137109 49.47 µM 0.73213928062025 0.227739174158305 no 786 0.232041780267376 996 17478346 SGTC_382 3229-0966 23.2 µM 0.731485956316777 0.227938374829403 no 787 0.232241189716963 1147 5722370 SGTC_1128 3448-9350 235 µM 0.730410768233116 0.228266416416066 no 788 0.232569569093903 1080 619386 SGTC_27 0485-0001 32.618 µM 0.729878623514505 0.22842887273504 no 789 0.232732189925197 1084 2054479 SGTC_227 fluconazole 33.516 µM 0.729491228314914 0.228547179905343 no 790 0.232850615745773 1148 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2381 9035592 200 µM 0.729075700538825 0.228674116771834 no 791 0.23297767883638 1085 4749657 SGTC_3004 9076122 71.4286 µM 0.727395748161689 0.229187717822535 no 792 0.233491779197508 1126 44782551 SGTC_1645 Cervolide 78 µM 0.726493034741646 0.229463965577674 no 793 0.23376828796116 1096 23173 A fragrance. SGTC_1995 st072814 61.1 µM 0.725273135984414 0.229837574465849 no 794 0.234142241461507 1114 5769371 SGTC_1921 5740136 50 µM 0.72354954080718 0.230366026595746 no 795 0.234671164598194 1154 1774243 SGTC_3103 9120822 49.47 µM 0.723512018416277 0.230377538464677 no 796 0.234682686513697 1202 17141819 SGTC_292 k038-0015 474 µM 0.723498883214953 0.230381568420236 no 797 0.234686719984103 1158 46368540 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.722972061971303 0.230543232705391 no 798 0.234848524349063 1093 1241132 A phosphatase inhibitor. SGTC_2225 6654152 15.4 µM 0.722382586140846 0.230724198777783 no 799 0.23502964509647 1120 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2529 gangaleoidin 93.61 µM 0.722111540735378 0.230807434958332 no 800 0.235112951665812 1173 4565183 SGTC_713 1488-1073 324 µM 0.721563270744662 0.230975856164018 no 801 0.235281513843713 1142 3312542 SGTC_1429 4049-0205 9.46 µM 0.721261867414274 0.231068472451789 no 802 0.235374206824814 1197 22774478 SGTC_1373 2887-0003 58.5 µM 0.720090324305979 0.231428665175084 no 803 0.235734692231998 1132 776948 SGTC_2954 9074818 52.69 µM 0.719929799244645 0.231478043227769 no 804 0.235784109716434 1129 16648742 SGTC_2297 7971671 152.32 µM 0.719610185012616 0.23157637513659 no 805 0.235882519653717 1157 909016 SGTC_3334 9142812 21.919 µM 0.718703763291811 0.23185536973272 no 806 0.23616173204374 1141 45283678 SGTC_1815 st051655 58.2 µM 0.717573046021357 0.232203664292792 no 807 0.236510291046169 1140 5984156 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.717482442491753 0.232231585470189 no 808 0.236538233064943 1183 115019 SGTC_2608 thymoquinone 42.66 µM 0.71250868263707 0.233767206027702 no 809 0.238074918373779 1108 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2694 st077685 81.9 µM 0.711985178719708 0.233929161656393 no 810 0.238236976995028 1164 2838096 SGTC_2033 5192550 145 µM 0.711496643991834 0.234080354976611 no 811 0.238388264867071 1165 182073 SGTC_1349 flufenamic acid 69 µM 0.709929020555902 0.234565873441919 no 812 0.23887407655118 1148 3371 A non-steroidal anti-inflammatory. SGTC_2735 sertaconazole 140 nM 0.708434224888308 0.235029354288873 no 813 0.23933782252533 1218 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1290 0986-0249 10.2 µM 0.708170456534531 0.235111191581882 no 814 0.239419705135033 1148 53329 SGTC_313 3474-0040 5.03 µM 0.707098451894665 0.235443955785939 no 815 0.239752648983436 1166 1043375 YIL048W NEO1 SGTC_1427 4048-4900 550 nM 0.706694871359604 0.235569299752289 no 816 0.239878058695931 1168 24132586 SGTC_2073 5212005 126 µM 0.704983013314177 0.236101377326551 no 817 0.240410403674499 1064 691789 SGTC_2486 5283202 22.39 µM 0.704314025295051 0.236309491132608 no 818 0.240618616934072 1140 1377751 SGTC_2277 7947813 106.88 µM 0.702937305632191 0.236738089037754 no 819 0.241047410575523 1201 1246798 SGTC_1 0258-0098 57.368 µM 0.701732764587636 0.2371134350101 no 820 0.241422917939778 1114 6790032 YDR047W HEM12 SGTC_1428 4049-0204 61.7 µM 0.701035515404498 0.237330853542057 no 821 0.241640425684006 1220 X1428 SGTC_374 0880-0231 82.3 µM 0.697828595462579 0.238332254173008 no 822 0.242642196855366 1172 6833587 SGTC_67 0335-0847 266 µM 0.697657030078242 0.238385892734271 no 823 0.242695853397011 1242 4552207 YOR254C SEC63 SGTC_405 ebelactone b 50 µM 0.696779563515252 0.23866032905761 no 824 0.242970378751667 1183 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1145 3546-0597 10.2 µM 0.696688648479996 0.2386887735129 no 825 0.24299883215138 1162 875334 SGTC_379 3970-0972 5.9 µM 0.695732207139362 0.238988126307258 no 826 0.24329827585355 1192 2898042 YBL034C STU1 SGTC_2054 5233173 129 µM 0.695510468731934 0.239057556633916 no 827 0.24336772642414 1193 6889 SGTC_2949 9072542 2.23 µM 0.692488276108582 0.240004958498445 no 828 0.244315372965646 1227 16457352 SGTC_702 1488-0190 94 µM 0.692230690428072 0.240085801451911 no 829 0.2443962340798 1200 949357 SGTC_1843 st055809 45.5 µM 0.691959110588724 0.240171052529432 no 830 0.244481503846204 1190 16413835 SGTC_2369 9071472 200 µM 0.690915437324719 0.240498823371021 no 831 0.244809342128542 1228 17296037 SGTC_2854 9024559 71.43 µM 0.6909005666309 0.240503495346727 no 832 0.244814015014932 1186 3163529 SGTC_171 k064-0041 9.68 µM 0.690656863510196 0.240580067414009 no 833 0.244890601805499 1164 53325 SGTC_2580 diallyl disulphide 81.36 µM 0.68993571566938 0.240806731413152 no 834 0.245117307151186 1207 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_237 nikkomycin 200 µM 0.687350822128781 0.241620143229409 no 835 0.245930839871167 1242 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3110 9122132 49.47 µM 0.687140786772835 0.241686302420452 no 836 0.245997007009914 1277 918317 SGTC_2147 5545932 89.7195 µM 0.686706434171146 0.241823150654925 no 837 0.246133870785159 1211 797404 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.685651724057735 0.242155625241097 no 838 0.24646637808428 1224 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_60 0986-0278 202 µM 0.685136994764686 0.242317972473641 no 839 0.246628738696851 1054 3110598 SGTC_547 1120-0019 610 nM 0.684961092153151 0.242373466228081 no 840 0.246684236634938 1172 3676939 SGTC_53 0973-0023 39.979 µM 0.68493264139544 0.242382442519789 no 841 0.246693213584704 1192 674768 SGTC_1179 1021-1431 9.29 µM 0.682749540385545 0.243071753724099 no 842 0.247382559823816 1202 2840958 SGTC_2541 muurolladie-3-one 83.07 µM 0.681883377868274 0.243345536845043 no 843 0.247656348383946 1235 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1360 1598-0022 39.8 µM 0.679744629225867 0.244022281683862 no 844 0.248333086048789 1239 761525 SGTC_2880 9042983 58.44 µM 0.679191634863978 0.24419742571109 no 845 0.248508223446329 1227 6464714 SGTC_1187 1391-0724 117 µM 0.678210853677484 0.244508224744019 no 846 0.248819005892965 1258 6997986 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.676850614724933 0.2449396223426 no 847 0.249250370263792 1204 15053 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.674681148303447 0.245628511768724 no 848 0.249939182091555 1242 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1499 4480-0877 67.3 µM 0.674490759476595 0.245689017205758 no 849 0.249999679274407 1168 2861909 SGTC_1874 staurosporine 7.6 µM 0.674336100220256 0.245738173700782 no 850 0.250048828892674 1239 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2222 6885208 172.143 µM 0.673996347446323 0.245846178376145 no 851 0.250156817921079 1197 609514 SGTC_347 4534-1311 26.2 µM 0.673497354403731 0.246004850432106 no 852 0.250315465650257 1246 2862016 SGTC_2326 6164455 177.58 µM 0.672945288097009 0.246180462964617 no 853 0.250491049401844 1221 2888790 SGTC_2465 5809242 33.21 µM 0.671248444863194 0.246720650138721 no 854 0.25103113583308 1236 2731748 SGTC_735 3076-0345 636 µM 0.669697483489644 0.247214950720253 no 855 0.251525328113176 1265 2888990 SGTC_2006 4011487 200 µM 0.666703873730878 0.24817052746182 no 856 0.252480651971882 1265 45595294 SGTC_909 3448-9333 149 µM 0.666341358986145 0.24828637774064 no 857 0.252596467704166 1205 3344074 SGTC_3254 9136651 49.47 µM 0.665410292720361 0.248584054370145 no 858 0.252894051719828 1230 16454030 SGTC_1073 triclabendazole 3.09 µM 0.664439876315787 0.248894514094358 no 859 0.253204408960528 1291 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2334 9017922 200 µM 0.664385101192802 0.248912044134798 no 860 0.253221933035003 1257 3163164 SGTC_1642 st009582 77.7 µM 0.664336432466323 0.248927620456591 no 861 0.25323750403967 1255 6739311 SGTC_1260 0700-1617 7.75 µM 0.663463067242221 0.249207227289179 no 862 0.253517012855537 1253 2853078 SGTC_481 bay k-8644 50 µM 0.663176886116599 0.249298884152466 no 863 0.253608636529337 1191 2303 A calcium channel antagonist. SGTC_2243 6634756 200 µM 0.662279831499061 0.249586305059952 no 864 0.25389594997315 1299 885676 SGTC_3278 9139605 49.47 µM 0.661713822171984 0.249767747894432 no 865 0.254077322326132 1279 7958859 SGTC_2705 st078069 42.8 µM 0.661525446072165 0.249828150227036 no 866 0.254137700742201 1228 1530061 SGTC_3288 9119690 36.221 µM 0.66082575788299 0.25005257140039 no 867 0.254362031073477 1228 17595618 YKL019W RAM2 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.659958381770373 0.250330925973065 no 868 0.254640268638199 1283 23847180 SGTC_248 streptozotocin 5.23457 mM 0.65916342488173 0.25058618428005 no 869 0.254895415432738 1285 5300 DNA alkylating agent. SGTC_706 4262-0057 46.9 µM 0.658565423237307 0.250778291678141 no 870 0.255087436251564 1228 883298 SGTC_592 k241-0073 46.5 µM 0.65849816256453 0.250799903975993 no 871 0.255109038666574 1268 4230158 SGTC_3217 9129673 49.47 µM 0.657966649916575 0.250970725078739 no 872 0.255279780642464 1245 17248312 SGTC_2643 anethole 100 µM 0.657206926490567 0.251214996951616 no 873 0.255523936239552 1245 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2671 danthron 100 µM 0.656590544830193 0.251413272870447 no 874 0.255722115075231 1220 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1313 1220-0047 237 µM 0.656056513697315 0.251585125354533 no 875 0.255893881457514 1279 3528706 SGTC_151 3013-0144 2.285 µM 0.655647223850121 0.251716877791791 no 876 0.256025566654618 1233 906558 YHR107C CDC12 SGTC_1978 st071761 42 µM 0.654058980261109 0.25222848613381 no 877 0.256536903794584 1218 5147680 SGTC_2715 st079500 56.4 µM 0.653604359742993 0.252375030320733 no 878 0.256683367342873 1222 28246688 SGTC_1309 pyrazolanthrone 13.4 µM 0.653305072100051 0.252471528382466 no 879 0.2567798115869 1284 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1854 st056233 32.9 µM 0.653256935053678 0.252487050823724 no 880 0.256795325317973 1223 5393174 SGTC_1389 3405-0187 19 µM 0.653070395725657 0.252547207701434 no 881 0.256855448300308 1222 799890 SGTC_1570 verbenone 133 µM 0.65176223556601 0.252969287007856 no 882 0.25727728356598 1282 29025 A natural terpanoid with antifungal properties. SGTC_686 1319-0111 510 µM 0.650001703130534 0.253537910139225 no 883 0.257845560742082 1337 4562600 SGTC_16 erodoxin 22.806 µM 0.649459225641993 0.253713256718445 no 884 0.258020796667338 1292 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2461 5755302 26.15 µM 0.649234117857105 0.253786037654472 no 885 0.258093531125299 1296 2788904 SGTC_2523 spermine 47.74 µM 0.648876273231601 0.253901757085422 no 886 0.258209175994811 1244 1103 A DNA binding polyamine. SGTC_1638 st008370 60.6 µM 0.648692194496185 0.253961295064579 no 887 0.258268675294995 1263 24207134 SGTC_2108 5365811 200 µM 0.648479770737072 0.25403000999338 no 888 0.258337345315459 1297 780283 SGTC_710 3448-4187 58 µM 0.647946848902018 0.254202442700357 no 889 0.258509664068123 1299 3946412 SGTC_2426 5582046 32.21 µM 0.646373493869975 0.254711876851522 no 890 0.25901875102698 1287 2251934 SGTC_2382 9035899 200 µM 0.645295710702983 0.255061158848909 no 891 0.25936778590676 1292 6462679 SGTC_2262 9014885 67.46 µM 0.644245132860877 0.255401865281787 no 892 0.259708244192456 1224 6457424 SGTC_936 3005-4620 401 µM 0.644107822875305 0.255446413005532 no 893 0.259752758953244 1317 777207 SGTC_3134 9127454 49.47 µM 0.643939259449279 0.255501105889718 no 894 0.259807411204064 1351 24262820 SGTC_1084 voriconazole 435 nM 0.643021865183786 0.255798875180138 no 895 0.260104956110777 1290 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2681 menadione 3.18 µM 0.642207738945334 0.256063277200842 no 896 0.260369154421131 1292 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2000 st075254 36.4 µM 0.640392736267545 0.256653244453021 no 897 0.2609586519987 1266 17234175 SGTC_1753 st043925 64 µM 0.63929083715371 0.257011762132395 no 898 0.26131687407473 1286 670181 SGTC_775 4577-0580 57.3 µM 0.639062654375457 0.257086037010822 no 899 0.2613910867511 1345 2006902 SGTC_1887 st057648 70.8 µM 0.638210921028028 0.257363379953389 no 900 0.261668194518063 1287 688672 SGTC_829 1635-0120 117 µM 0.634247494327273 0.258656000223711 no 901 0.262959658254369 1295 285054 SGTC_1742 st038235 28.8875 µM 0.633811517457411 0.258798393349551 no 902 0.263101917909638 1280 564103 YBR002C RER2 SGTC_1513 0337-0559 19 µM 0.633545614431076 0.258885259067807 no 903 0.263188701615384 1231 775073 SGTC_1085 doxorubicin 7.67 µM 0.631337338993692 0.259607245176901 no 904 0.26390998880481 1307 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1282 0886-0010 32.4 µM 0.630456933406522 0.259895379541024 no 905 0.264197835648208 1345 2836211 YNL267W PIK1 SGTC_1141 3253-0389 52.6 µM 0.629770707170425 0.26012007828658 no 906 0.264422306778939 1278 5402031 SGTC_1051 3253-3903 78 µM 0.629123758504484 0.260332007611814 no 907 0.264634018701869 1261 5509239 SGTC_406 estrone 100 µM 0.628832706385392 0.260427380314747 no 908 0.264729292707585 1360 5870 A steroid. SGTC_2563 tomatine 8.54 µM 0.628693993043802 0.260472840588493 no 909 0.264774705748303 1314 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1500 4488-1866 171 µM 0.627861659511246 0.260745705561357 no 910 0.265047284665562 1350 2900003 SGTC_2786 7743617 45.45 µM 0.627540758658485 0.260850946172295 no 911 0.26515241378102 1224 583674 SGTC_2726 cimetidine 79.27 µM 0.625769797787671 0.26143213205094 no 912 0.26573297224645 1293 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_504 lovastatin 124 µM 0.625356984015303 0.261567702899618 no 913 0.265868393898761 1258 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_794 k038-0031 316 µM 0.624483346393861 0.26185473038369 no 914 0.266155101965748 1316 6624242 SGTC_1520 flindersine 88 µM 0.624188806339177 0.261951535841496 no 915 0.266251798610022 1431 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1443 4112-3303 14 µM 0.622725568303362 0.262432725072838 no 916 0.266732438861207 1303 704433 SGTC_1928 4'-methoxychalcone 40.3 µM 0.622091790646323 0.262641284702318 no 917 0.266940756363388 1364 641818 SGTC_3285 9112818 20.8695 µM 0.620814743439419 0.263061784954832 no 918 0.267360760754358 1332 17017947 YPR165W RHO1 SGTC_602 3130-1533 38.1 µM 0.620708395900816 0.263096818097411 no 919 0.267395752122284 1350 720941 SGTC_2611 pyromycin 23.93 µM 0.619877219969677 0.263370707244777 no 920 0.267669312223958 1295 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1245 0418-0076 17.2 µM 0.619650625420269 0.263445399940817 no 921 0.267743914431616 1329 6790114 SGTC_1438 4092-1045 4 µM 0.619079506258358 0.263633706754679 no 922 0.267931991683701 1291 1351342 SGTC_3161 9100388 49.47 µM 0.618885341722282 0.26369774144041 no 923 0.267995947838603 1346 25236368 SGTC_1186 1319-0216 26 µM 0.618822370347108 0.263718510851132 no 924 0.268016691727244 1367 4565136 SGTC_766 1391-0721 126 µM 0.617772527303614 0.264064896145244 no 925 0.268362647699936 1360 1020919 YIL115C NUP159 SGTC_979 1426-2828 121 µM 0.617501049810902 0.264154505157538 no 926 0.268452144520459 1380 747872 SGTC_1361 1608-0041 5.61 µM 0.616860415669764 0.264366026403876 no 927 0.268663399103125 1296 X1361 SGTC_2661 dactinomycin 12.96 µM 0.61439476821267 0.265180924780991 no 928 0.269477246077024 1321 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2805 7950783 58.44 µM 0.614366184493447 0.265190379196167 no 929 0.269486688070014 1339 1178958 YDL195W SEC31 SGTC_2560 caryophyllene 100 µM 0.609774818550609 0.26671124829487 no 930 0.271005492306768 1350 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2932 9016711 44.54 µM 0.608138410844864 0.267254364633805 no 931 0.271547839303688 1334 7117328 SGTC_613 3914-0030 117 µM 0.606127766637963 0.267922451684349 no 932 0.272214957020533 1172 1145395 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.605452679263407 0.268146954883518 no 933 0.272439128811964 1313 2374 Ca(2+)-ATPase inhibitor. SGTC_633 0437-0093 97.7 µM 0.604166235717133 0.268575029137064 no 934 0.272866563257246 1336 2831118 SGTC_1033 k072-0102 21.3 µM 0.603858256008333 0.268677562752553 no 935 0.272968942088787 1315 5965931 SGTC_665 3914-0008 307 µM 0.602450942192209 0.269146340421243 no 936 0.273437004549703 1286 1069549 SGTC_1328 1441-0025 69.2 µM 0.602251262023809 0.269212887317665 no 937 0.273503448913919 1255 4562601 SGTC_2031 5180455 200 µM 0.602194352061742 0.269231855065708 no 938 0.273522387391779 1294 29949 SGTC_1191 1487-1166 10.6 µM 0.602021915613909 0.269289331188926 no 939 0.273579774696906 1418 3955771 SGTC_2598 perillyl alcohol 100 µM 0.601857187470607 0.269344243744186 no 940 0.27363460222213 1385 10819 An apoptosis inducer. SGTC_2344 7990960 76.95 µM 0.601851437903385 0.269346160478784 no 941 0.273636515985675 1346 140813 SGTC_2226 7298446 200 µM 0.601264541561033 0.269541850226628 no 942 0.273831901316751 1335 3283010 SGTC_2936 9038235 15.59 µM 0.599702298233264 0.27006309841339 no 943 0.27435232816188 1331 4749415 SGTC_914 3820-6779 408 µM 0.599413373789567 0.27015955433898 no 944 0.274448630430719 1315 2893481 SGTC_776 4476-4378 112 µM 0.597616021646997 0.270759977754094 no 945 0.275048085657653 1334 2892008 SGTC_2355 9061122 103.12 µM 0.597452414289188 0.27081466548717 no 946 0.275102684205861 1338 5302957 SGTC_2652 actinonin 100 µM 0.596878148676096 0.271006664326032 no 947 0.275294368611905 1316 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2227 7312221 64.1025 µM 0.59577994396488 0.271374024932349 no 948 0.275661121874684 1348 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1411 3909-8223 150 µM 0.594850001684324 0.271685293949323 no 949 0.275971870406396 1355 X1411 SGTC_1644 st010134 20.9 µM 0.593353364745753 0.272186619136787 no 950 0.276472345998434 1326 3818134 SGTC_95 0471-0001 561.058 µM 0.592506553940996 0.272470477022692 no 951 0.276755716654029 1260 4015405 SGTC_2564 betulinic acid 100 µM 0.591596390421659 0.27277573507884 no 952 0.277060445772698 1453 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_146 3448-8650 53.125 µM 0.589480043699095 0.273486187964722 no 953 0.277769647698356 1386 2891488 YIL048W NEO1 SGTC_3284 9108171 64.8615 µM 0.586722283409629 0.274413334284531 no 954 0.278695119728466 1361 8687505 SGTC_1809 st050081 57.6 µM 0.585308100774314 0.274889376977697 no 955 0.279170284442204 1411 5036894 SGTC_1307 1187-1599 12.2 µM 0.582706303559258 0.275766256718665 no 956 0.28004551451893 1346 1538471 SGTC_1176 0848-0131 83.3 µM 0.581895937550118 0.276039653628306 no 957 0.280318388521597 1419 6769040 SGTC_3165 9101544 49.47 µM 0.581891223893168 0.27604124428569 no 958 0.280319976124747 1380 5002184 SGTC_2948 9070189 9.45 µM 0.58173738672217 0.27609316021393 no 959 0.280371792293315 1325 6473636 YDL196W YDL196W SGTC_1090 efavirenz 20.7 µM 0.581556018104112 0.276154373425255 no 960 0.280432887691475 1384 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_49 0717-0965 32.132 µM 0.578876697627728 0.277059438640276 no 961 0.281336187258814 1440 5889349 YGL099W LSG1 SGTC_308 4092-1169 104 µM 0.576789626259096 0.277765448568374 no 962 0.282040789091989 1366 2268590 YDL196W YDL196W SGTC_1562 morin hydrate 59.1 µM 0.576125788988638 0.277990193999634 no 963 0.282265080639067 1394 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1987 st072290 61.9 µM 0.574853507396078 0.278421179146061 no 964 0.282695187783735 1406 54697379 SGTC_2837 9008476 45.46 µM 0.574297510145353 0.278609625290219 no 965 0.282883246888417 1400 2992805 SGTC_1565 sinapyl alcohol 95.1 µM 0.572838230272271 0.279104519509961 no 966 0.283377115598002 1335 5280507 A phenol propionate derived from cinnamic acid. SGTC_2745 rifampicin 24.3 µM 0.571026233081992 0.279719627092124 no 967 0.283990930286241 1381 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3057 9095946 49.47 µM 0.569321406667686 0.280298954006543 no 968 0.284569021038613 1413 24540043 SGTC_590 k048-0076 22.4 µM 0.569158557815297 0.280354323007641 no 969 0.284624270957485 1444 6832814 SGTC_2684 capsaicin 100 µM 0.566887448760762 0.281127057024647 no 970 0.285395326041983 1372 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1203 3992-3522 103 µM 0.566087534339909 0.281399468863649 no 971 0.285667138451552 1617 5322312 SGTC_2314 7727897 200 µM 0.565653986027512 0.281547167487082 no 972 0.285814510427638 1360 900724 SGTC_1694 st024011 44.9 µM 0.564462982816026 0.281953103625651 no 973 0.286219542861281 1433 2787533 SGTC_2720 fluspirilene 36.88 µM 0.562566714244145 0.282600000414994 no 974 0.286864981533059 1398 3396 An atypical antipsychotic. SGTC_883 0850-0245 24.6 µM 0.562430516286235 0.282646490701461 no 975 0.28691136618004 1480 6823229 YPR165W RHO1 SGTC_2304 7443016 91.4 µM 0.561554790004777 0.282945501934114 no 976 0.287209695253876 1373 939854 SGTC_3029 9088683 49.47 µM 0.560833721630873 0.28319182015375 no 977 0.2874554479968 1403 25236615 SGTC_3182 9108849 49.47 µM 0.560284510303491 0.283379500695567 no 978 0.287642695538871 1390 17133045 SGTC_307 1501-1223 22.3 µM 0.56024431068076 0.283393240348752 no 979 0.287656403420553 1378 2830329 SGTC_1786 berberine 21.6 µM 0.559407797747506 0.283679220889915 no 980 0.287941720414819 1357 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3084 9116877 49.47 µM 0.559380151910238 0.28368867459304 no 981 0.287951152109791 1336 27241325 SGTC_1262 0737-0114 49.6 µM 0.558956220309341 0.283833660104281 no 982 0.288095799509532 1413 765919 SGTC_1112 tnp00069 1.16933 µM 0.557810297526096 0.284225745575745 no 983 0.288486965114665 1470 145826 SGTC_736 0958-0254 92.6 µM 0.55758861532141 0.284301625570105 no 984 0.288562666160011 1447 6812352 SGTC_2470 5664817 21.68 µM 0.557432555628342 0.284355049325641 no 985 0.288615963745063 1428 2859561 SGTC_874 0599-0792 117 µM 0.557163417160088 0.284447194492621 no 986 0.28870789094336 1431 765305 SGTC_1006 4099-6547 255 µM 0.556864053727544 0.28454970456161 no 987 0.28881015800492 1431 3146833 SGTC_2111 5486399 200 µM 0.556162909417461 0.284789864208065 no 988 0.289049746190019 1391 689674 SGTC_913 3487-1245 167 µM 0.55501517976057 0.285183199250395 no 989 0.289442138799847 1340 4016153 SGTC_1672 st016598 6.51 µM 0.552387921529445 0.286084552498491 no 990 0.290341302084782 1362 4665860 YNL267W PIK1 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.552201668146231 0.286148503193584 no 991 0.29040509580253 1379 4620898 SGTC_2295 7971645 200 µM 0.552000007372255 0.286217751721156 no 992 0.290474174109662 1470 2978226 YKL099C UTP11 SGTC_2132 5317594 122.667 µM 0.548116884263305 0.287552731462312 no 993 0.291805823925523 1450 794577 SGTC_1701 st028638 40.4 µM 0.547731228590097 0.287685476646969 no 994 0.291938232977516 1484 3490878 SGTC_1791 st048313 56.1 µM 0.547176880319333 0.287876337631451 no 995 0.292128609084086 1425 1204976 SGTC_1875 nocodazole 6 µM 0.542325641479908 0.289549155351565 no 996 0.293797097226091 1423 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3190 9110366 49.47 µM 0.541497677250043 0.289835111633139 no 997 0.294082299104884 1431 17123768 SGTC_1714 st033236 13.627 µM 0.539770354188421 0.290432108039444 no 998 0.294677707134871 1522 2916566 SGTC_1139 k015-0024 46.9 µM 0.539008923945248 0.290695455805227 no 999 0.294940348487141 1420 2766652 SGTC_2606 farnesol 9.78 µM 0.538742530672883 0.290787616772525 no 1000 0.295032261408735 1493 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_965 1291-5240 308 µM 0.537802312604447 0.291113002176235 no 1001 0.295356767619919 1496 2834598 SGTC_2883 9059145 45.46 µM 0.536438087116606 0.291585427819779 no 1002 0.295827907245699 1406 16476510 SGTC_3005 9076496 71.4286 µM 0.535950670115466 0.29175430494277 no 1003 0.295996321926437 1450 21368410 SGTC_3060 1327-0027 12.5 µM 0.535726128021842 0.29183211818177 no 1004 0.296073921603016 1387 16000455 YPR107C YTH1 SGTC_807 1315-0151 48 µM 0.535195765204752 0.292015949485404 no 1005 0.296257247161181 1506 4011080 SGTC_2205 7238770 200 µM 0.532313262861563 0.293016007313142 no 1006 0.297254523940554 1463 279867 SGTC_2256 7954252 200 µM 0.532000329655149 0.293124672171045 no 1007 0.297362883592554 1385 2972920 SGTC_2285 7945142 200 µM 0.531033546971055 0.293460501755741 no 1008 0.297697766201424 1438 2970608 SGTC_1553 gossypol 38.6 µM 0.5306395391139 0.293597418664891 no 1009 0.297834295412945 1378 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1988 st071872 53.4 µM 0.528751657568402 0.294253863555139 no 1010 0.298488868501875 1472 16414116 SGTC_2702 st077768 96.8 µM 0.528662371068555 0.294284926601328 no 1011 0.298519842442067 1395 6484119 SGTC_40 0327-0103 19.753 µM 0.52854601040551 0.294325411104539 no 1012 0.298560210741239 1405 409036 SGTC_432 NS 1619 61.3 µM 0.527884445486055 0.294555633349215 no 1013 0.298789770620811 1443 4552 A K+/calcium channel activator. SGTC_2802 7925815 54.55 µM 0.527255076456236 0.294774728633294 no 1014 0.299008233105734 1419 1262923 SGTC_2190 6049624 200 µM 0.526075834064207 0.295185447410808 no 1015 0.299417759208653 1443 2265554 SGTC_1511 0906-3109 28.5 µM 0.525522584643709 0.295378229616945 no 1016 0.299609978715681 1449 2882180 SGTC_1152 3909-8331 15.9 µM 0.525443350381379 0.295405843887226 no 1017 0.299637512233781 1421 16001939 SGTC_897 1000-0139 31.4 µM 0.524556751949699 0.295714917043771 no 1018 0.299945678995191 1513 6151020 SGTC_2391 6285546 200 µM 0.523398910431207 0.296118770644691 no 1019 0.300348341129255 1412 846083 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.519681956669778 0.297416946319708 no 1020 0.301642632430064 1447 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.518707911095868 0.297757568836031 no 1021 0.301982222033983 1514 688751 SGTC_2414 st077232 92.9 µM 0.51775496605492 0.298090984630885 no 1022 0.302314621268349 1403 729801 SGTC_132 0417-1715 25.805 µM 0.516722421567186 0.298452442515501 no 1023 0.302674970955205 1561 6769098 SGTC_2565 isoliquiritigenin 100 µM 0.515929530555099 0.298730141359747 no 1024 0.302951814067888 1379 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3138 9097216 49.47 µM 0.515836228703798 0.29876282673379 no 1025 0.302984398474328 1429 25237486 SGTC_1180 1193-0155 285 µM 0.515476371350561 0.298888906680265 no 1026 0.303110088462631 1430 2921347 SGTC_1713 st033146 12.748 µM 0.515357540427775 0.298930545697708 no 1027 0.30315159852286 1552 674619 SGTC_2011 4012611 177 µM 0.51481015805937 0.299122385544497 no 1028 0.303342843146022 1427 2049887 SGTC_1561 5-methoxyflavone 52.9 µM 0.514077082419009 0.299379392386093 no 1029 0.303599049764031 1437 94525 SGTC_2755 lomerizine 42.69 µM 0.513837518677154 0.299463402041405 no 1030 0.303682797148384 1440 3949 A calcium channel blocker. SGTC_2930 9013230 14.89 µM 0.513655720859389 0.299527161608634 no 1031 0.303746357434889 1541 2995857 SGTC_754 3474-0146 171 µM 0.510515086148753 0.300629605133261 no 1032 0.304845324107737 1377 24762078 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.508963851254428 0.301174803407233 no 1033 0.305388781239112 1410 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2877 9040724 71.43 µM 0.508356517724522 0.301388378614215 no 1034 0.305601670467641 1554 6463895 SGTC_82 0054-0107 293.755 µM 0.508246774408345 0.301426978274503 no 1035 0.305640145916057 1534 3104697 SGTC_2707 st078556 66.6 µM 0.507994530197428 0.301515707745574 no 1036 0.305728589588106 1520 17250899 SGTC_320 4092-0846 5.34 µM 0.507359089639898 0.301739282511263 no 1037 0.305951442537093 1514 1359356 SGTC_2275 7947463 200 µM 0.506139225746123 0.302168690769129 no 1038 0.306379457705573 1453 1225414 SGTC_1975 st070967 30.8 µM 0.506066911530608 0.302194154941683 no 1039 0.306404838989189 1543 261391 SGTC_2069 5228469 200 µM 0.504464220049531 0.302758761437542 no 1040 0.306967599643243 1423 2835210 SGTC_1430 4049-0248 69.1 µM 0.502271497717011 0.303531992199587 no 1041 0.307738277793284 1563 22774488 SGTC_2739 tacrine 100.86 µM 0.501893192058073 0.303665485193431 no 1042 0.307871327209832 1465 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2892 9047358 58.44 µM 0.501112084618143 0.303941198026192 no 1043 0.308146121204638 1448 6466771 SGTC_1795 st049545 62.3 µM 0.500311791515231 0.304223798667106 no 1044 0.308427776302044 1510 5291882 SGTC_3211 9128781 49.47 µM 0.499035324571907 0.304674788533797 no 1045 0.308877249364157 1476 17194361 SGTC_800 3448-7362 155 µM 0.498987463941843 0.304691704004117 no 1046 0.308894107755377 1541 15991913 SGTC_2059 5238311 157 µM 0.498262552351718 0.304947961882249 no 1047 0.309149499266056 1452 703021 SGTC_1347 1493-0251 600 nM 0.498077571610701 0.305013368319819 no 1048 0.309214684076781 1566 3986378 SGTC_578 3460-0051 92 µM 0.497900437384222 0.30507600618546 no 1049 0.309277109507028 1516 2876744 SGTC_2007 4011539 71.82 µM 0.497835493225212 0.305098973045304 no 1050 0.309299998428609 1479 45595301 SGTC_476 mead acid 10 µM 0.49764720249484 0.305165564539399 no 1051 0.309366363802802 1507 5312531 An omega 9 fatty acid. SGTC_1396 3511-0007 98.6 µM 0.49763389929048 0.305170269636639 no 1052 0.309371052915355 1453 X1396 SGTC_2836 9010338 19.48 µM 0.497629233252959 0.305171919935405 no 1053 0.309372697607291 1357 2994051 SGTC_2537 larixol 68.93 µM 0.495908394699338 0.305780821392988 no 1054 0.309979521565012 1537 6708759 SGTC_2528 xanthyletin 44.79 µM 0.495292307284697 0.305998948455712 no 1055 0.310196900149248 1520 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2324 6149169 200 µM 0.4946614794354 0.306222365709413 no 1056 0.310419548448947 1489 2888231 SGTC_2594 a-mangostin 100 µM 0.4925629369382 0.306966114764541 no 1057 0.311160720774062 1596 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_585 0kpi-0023 191 µM 0.492103166581636 0.307129169274632 no 1058 0.31132320691038 1552 64601 SGTC_1061 3448-9325 110 µM 0.491751215170312 0.3072540122885 no 1059 0.311447613905847 1474 723482 SGTC_1767 st044992 70.3 µM 0.491569928586773 0.30731832637042 no 1060 0.311511703083889 1433 9600693 SGTC_480 am 92016 50 µM 0.491219757883173 0.307442571354548 no 1061 0.311635513039894 1436 2129 K+ channel blocker. SGTC_252 miconazole 1.30953 nM 0.491042599890556 0.307505437664425 no 1062 0.311698158956194 1482 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2261 9010538 184.68 µM 0.490401576827529 0.307732958433549 no 1063 0.311924880550016 1429 6457250 SGTC_770 0389-1121 67.2 µM 0.48788885068438 0.308625522459428 no 1064 0.312814286085711 1596 6753108 SGTC_2109 5483026 200 µM 0.487797409378979 0.308658025377417 no 1065 0.312846673286332 1536 759335 SGTC_1267 0828-0272 9.49 µM 0.486850599579361 0.308994658103163 no 1066 0.313182104639008 1609 745334 SGTC_2900 5328528 85.29 µM 0.486203143143192 0.309224949893036 no 1067 0.313411571533025 1447 795359 SGTC_1224 0823-0416 294 µM 0.486183780209891 0.309231838190294 no 1068 0.313418435118777 1573 3598164 SGTC_514 4466-0038 2.65 nM 0.485374694349345 0.30951972763273 no 1069 0.313705289801455 1535 5722064 SGTC_3308 9128332 17.569 µM 0.484427215590082 0.30985700876071 no 1070 0.314041353758151 1609 17332805 YDL196W YDL196W SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.484263569660506 0.309915279254141 no 1071 0.31409941343334 1519 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_404 fumagillin 50 µM 0.483964012933347 0.31002195677927 no 1072 0.31420570460049 1518 12015870 A methionine aminopeptidase binder. SGTC_1021 4476-0760 85.3 µM 0.481315467727585 0.31096584628974 no 1073 0.315146152708575 1467 746768 SGTC_274 sirtinol 40.1 µM 0.480811464192407 0.311145604438449 no 1074 0.315325250810616 1461 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1137 ixabepilone 100 µM 0.479251372519687 0.311702312940847 no 1075 0.315879905739449 1477 154225 A novel microtubule stabilizer. SGTC_214 4373-3496 70 µM 0.479247333226739 0.311703754895529 no 1076 0.315881342356615 1564 3779166 SGTC_1440 4100-1550 40 µM 0.479204821788933 0.311718930886665 no 1077 0.315896462166767 1530 742806 SGTC_3227 9130768 49.47 µM 0.478850661609737 0.311845373563802 no 1078 0.316022436347169 1542 17720899 SGTC_1716 st033144 30.6155 µM 0.477782874133998 0.312226730484334 no 1079 0.31640237582528 1606 674617 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.476142910807553 0.312812830061917 no 1080 0.316986284001797 1503 3256 An antibiotic and ribosome inhibitor. SGTC_3079 9117512 49.47 µM 0.475552086172063 0.313024098493235 no 1081 0.317196758665401 1577 7185044 SGTC_324 1315-0088 19.6 µM 0.475122368826186 0.313177796388098 no 1082 0.317349877815678 1534 6787421 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.475079737559204 0.313193046172262 no 1083 0.317365070118588 1520 6857784 SGTC_1891 st059073 26.2 µM 0.47242348194267 0.314143854195666 no 1084 0.31831227336552 1660 688754 SGTC_1042 0350-0096 82 µM 0.472247526604347 0.314206881172273 no 1085 0.318375059939143 1480 3122515 SGTC_940 3232-1287 54.8 µM 0.470471719128635 0.314843276150944 no 1086 0.319009017448291 1507 1585493 YIL048W NEO1 SGTC_3222 9128301 49.47 µM 0.469285703475596 0.315268614410608 no 1087 0.319432716405767 1521 4911358 SGTC_1963 st076565 50.3 µM 0.466883073119415 0.316131014985326 no 1088 0.32029176816863 1521 4914280 SGTC_2835 9006588 71.43 µM 0.465521749970735 0.31662009330676 no 1089 0.320778932484928 1515 2345538 SGTC_3056 9094900 49.47 µM 0.465423778647263 0.316655303541867 no 1090 0.3208140045111 1450 25236784 SGTC_471 1-acyl-paf 4 µM 0.465011945467321 0.316803331785222 no 1091 0.320961451099251 1455 16759367 SGTC_1959 st077091 55.8 µM 0.464338967628778 0.317045288311863 no 1092 0.321202454781348 1514 821356 YKL052C ASK1 SGTC_1320 1313-0481 95.3 µM 0.462288604066919 0.317782939989232 no 1093 0.321937185380905 1604 6813365 YLR208W SEC13 SGTC_3099 9120367 49.47 µM 0.459133735787595 0.318919368236066 no 1094 0.323069065977706 1541 24824940 SGTC_275 trichlorophene 5.69 µM 0.458516720061481 0.319141825650895 no 1095 0.32329062647352 1576 62616 SGTC_1503 4585-0012 61.3 µM 0.457508297826606 0.31950554006992 no 1096 0.32365286972402 1612 2922052 SGTC_718 1130-0073 349 µM 0.457326343885682 0.319571185128463 no 1097 0.323718248635118 1612 6740020 SGTC_483 fpl-64176 144 µM 0.455162471736633 0.320352296499184 no 1098 0.324496178513774 1549 3423 SGTC_1302 1159-0335 255 µM 0.455085325811476 0.320380159247248 no 1099 0.324523927279067 1521 649284 SGTC_1119 parthenolide 318.541 nM 0.453756135774456 0.320860380926838 no 1100 0.325002179068087 1650 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_684 1140-0066 328 µM 0.453599079322716 0.320917143513271 no 1101 0.325058708141875 1531 6813534 SGTC_863 0466-0191 129 µM 0.452577692379798 0.321286390345703 no 1102 0.325426432496138 1608 765160 YPR165W RHO1 SGTC_1656 st012921 11 µM 0.452327655693105 0.321376809330479 no 1103 0.325516477753856 1592 6732821 SGTC_2281 7943571 200 µM 0.451854923847057 0.321547788903986 no 1104 0.325686749641457 1640 1244024 SGTC_1923 st058458 19.1 µM 0.450588175482318 0.322006137927067 no 1105 0.326143195240634 1675 3534982 SGTC_889 0919-1524 82.7 µM 0.449969374875272 0.32223013779737 no 1106 0.326366261547193 1523 3905452 SGTC_3140 9094243 49.47 µM 0.449567344896232 0.32237570339699 no 1107 0.326511219299013 1538 19291112 SGTC_1740 st038286 13.222 µM 0.449317102612878 0.322466323998116 no 1108 0.326601461022856 1589 716786 SGTC_2674 ligustilide 100 µM 0.448482828853523 0.322768516951363 no 1109 0.326902387944835 1559 5319022 A signalling regulator. SGTC_59 0330-0160 1.33 µM 0.447741604400811 0.323037103556773 no 1110 0.327169845974005 1567 4293482 SGTC_194 1486-1323 56.904 µM 0.447520985495743 0.323117063816139 no 1111 0.32724946964147 1520 5178754 SGTC_1647 st011722 22.4 µM 0.445992830775808 0.323671146513207 no 1112 0.327801212301806 1577 2854783 SGTC_2416 tofa 880 nM 0.44528790572556 0.323926872143665 no 1113 0.328055853443558 1466 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_715 0868-0130 184 µM 0.445264858048976 0.323935234552275 no 1114 0.328064180340777 1715 2876258 SGTC_94 0334-0113 514.748 µM 0.443971256919074 0.324404735333244 no 1115 0.328531682507795 1501 6795178 SGTC_1985 st071382 65.5 µM 0.440202209670415 0.325774266864312 no 1116 0.329895329743371 1557 6123237 SGTC_1413 3910-0535 34.4 µM 0.439657109363323 0.32597253135175 no 1117 0.330092735686106 1646 2876951 SGTC_3106 9121286 49.47 µM 0.438649007243493 0.326339329009776 no 1118 0.330457940555147 1619 15943471 SGTC_211 3455-0679 143.504 µM 0.438458955752017 0.326408498022367 no 1119 0.330526808560831 1581 748649 SGTC_2722 naftopidil 47.16 µM 0.437586286503207 0.326726181559385 no 1120 0.33084310698542 1613 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1481 3346-2004 36 µM 0.435830426080406 0.327365759613406 no 1121 0.331479883372828 1568 2770522 SGTC_1023 4482-3888 16 µM 0.434408691084479 0.327884003016745 no 1122 0.331995843823354 1669 3303168 SGTC_999 SEC7.066 22.7 µM 0.433415302303134 0.328246304774453 no 1123 0.332356542793373 1629 740511 YDR170C SEC7 SGTC_2065 5221596 34.26 µM 0.432738648489873 0.328493181744184 no 1124 0.332602324410399 1604 788581 SGTC_1339 1486-1321 22.7 µM 0.432480739175582 0.328587299610292 no 1125 0.332696024010285 1572 3469382 SGTC_2060 5238662 140 µM 0.431421874355765 0.328973821055364 no 1126 0.333080823792046 1566 790130 SGTC_396 dithiazanine 1.25 µM 0.431043214197531 0.329112089242985 no 1127 0.333218474562809 1539 10578 An antihelmenthic. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.430097120334174 0.329457658651673 no 1128 0.333562497346687 1556 688803 SGTC_1054 3429-0080 167 µM 0.428738764845138 0.329954065101036 no 1129 0.33405667326671 1655 1162877 SGTC_2811 7967822 32.47 µM 0.428307050525268 0.33011189642906 no 1130 0.334213793227044 1670 2232244 SGTC_2798 7813637 45.45 µM 0.42818141033529 0.330157835167122 no 1131 0.334259524715803 1635 956368 SGTC_690 glyoxal 20.3 µM 0.427226597330251 0.33050703403303 no 1132 0.334607145294327 1530 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_148 3253-0744 288.01 µM 0.427124000351 0.330544565088514 no 1133 0.334644506414225 1548 6893655 SGTC_1648 st011736 69.8 µM 0.424294761911536 0.33158020062546 no 1134 0.335675429424975 1657 2855514 SGTC_1572 epiandrosterone 68.9 µM 0.423922657808687 0.331716504453518 no 1135 0.335811109676339 1640 441302 A steroid. SGTC_1737 st035557 69.7 µM 0.423634241035669 0.331822168471319 no 1136 0.335916289757463 1538 5716916 SGTC_1625 st003711 30.1 µM 0.423363036570837 0.331921538814723 no 1137 0.336015204563534 1671 24207034 YER133W GLC7 SGTC_1653 st012112 65 µM 0.422924278701416 0.332082326396413 no 1138 0.336175254183723 1653 720429 SGTC_2989 9073649 71.4286 µM 0.42266415983176 0.332177664380472 no 1139 0.336270154088867 1673 21367202 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.421721165123172 0.332523378993593 no 1140 0.336614276962912 1648 5377381 SGTC_877 0771-0151 33.1 µM 0.420825279908212 0.33285195464409 no 1141 0.336941335174371 1621 6166523 SGTC_3088 9117578 49.47 µM 0.419649759435204 0.333283284321164 no 1142 0.337370666060157 1617 678341 SGTC_2943 9068529 45.32 µM 0.419254786789948 0.333428259808085 no 1143 0.337514967993925 1591 3270634 SGTC_1547 harmine 94.2 µM 0.419125089445171 0.333475870902002 no 1144 0.337562357697606 1603 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_271 rotenone 740 µM 0.419120985645956 0.333477377425124 no 1145 0.337563857213905 1645 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_771 0250-0039 27.3 µM 0.419074293298254 0.333494518584778 no 1146 0.337580918643583 1603 3005115 SGTC_230 MPP+ 141.667 µM 0.417503584685576 0.334071341484426 no 1147 0.338155051430647 1538 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2321 7390090 138.78 µM 0.417308623801122 0.334142965794087 no 1148 0.338226340747573 1519 649046 SGTC_2869 9037858 32.47 µM 0.416279063667092 0.33452130350029 no 1149 0.338602905422516 1540 27187042 SGTC_554 4483-2211 187 µM 0.415190339700998 0.334921565322821 no 1150 0.339001285042998 1611 747107 SGTC_561 1550-0330 72.9 µM 0.414546631793084 0.335158308350506 no 1151 0.339236911699009 1570 6812934 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.4129536267441 0.335744465519146 no 1152 0.339820294906886 1559 4174840 SGTC_306 1672-3436 11.6 µM 0.412689684540519 0.335841623520424 no 1153 0.339916991750223 1649 6797378 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.412663547217929 0.335851245352808 no 1154 0.339926567891768 1707 688664 SGTC_2080 5212524 12.4 µM 0.40786521945952 0.337619452631477 no 1155 0.341686314296358 1727 260183 SGTC_41 0478-0632 82.643 µM 0.406795335355384 0.338014201117936 no 1156 0.34207915651708 1718 3750424 SGTC_2386 9075165 157.42 µM 0.4040177380129 0.339039864856961 no 1157 0.343099837726639 1635 16452277 SGTC_88 0180-0332 8.668 µM 0.403597370575738 0.339195195195557 no 1158 0.343254409782623 1655 3101745 SGTC_3023 9089636 49.47 µM 0.401642269756623 0.339917985037122 no 1159 0.343973658352819 1696 17249241 SGTC_2857 9024691 58.44 µM 0.400792941010244 0.340232160757781 no 1160 0.34428628822865 1618 16478292 SGTC_1183 1254-0324 198 µM 0.400586253309443 0.340308633525715 no 1161 0.34436238412591 1701 5799357 SGTC_1275 0867-0008 21.1 µM 0.399391488545527 0.340750815398499 no 1162 0.344802382249841 1648 3422836 SGTC_3229 9132204 49.47 µM 0.399258920241 0.340799892368638 no 1163 0.344851216366243 1672 17682924 SGTC_2649 anisomycin 9.56 µM 0.398295672006051 0.341156569077493 no 1164 0.345206125189093 1633 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1970 st070122 35.8 µM 0.396849156753021 0.341692459101136 no 1165 0.345739349483249 1679 102928 SGTC_2122 5258151 111.688 µM 0.391644533504604 0.34362324806002 no 1166 0.347660439117547 1608 2173356 SGTC_108 0509-0257 621.132 µM 0.391073719615287 0.343835255751233 no 1167 0.347871372780553 1666 536624 SGTC_444 curcumin 90.4 µM 0.390484505895611 0.344054148895467 no 1168 0.348089155151693 1671 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_852 0418-0143 439 µM 0.389533566778628 0.344407533402261 no 1169 0.348440742418843 1726 5369229 SGTC_1556 plumbagin 1.48 µM 0.388542798585949 0.344775863570534 no 1170 0.348807194099517 1629 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_683 panaxydol 45 µM 0.38699961714931 0.345349853151078 no 1171 0.349378245691922 1735 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1226 3909-7979 35.4 µM 0.386759504955021 0.345439195412763 no 1172 0.349467129488277 1755 6615510 SGTC_2597 laccaic acid a 100 µM 0.385409632485642 0.34594162353286 no 1173 0.349966973540856 1653 5491415 A textile dye. SGTC_1811 st050069 61.5 µM 0.383165934232199 0.346777337374 no 1174 0.350798367305724 1717 3877702 SGTC_907 3448-6986 75.5 µM 0.381989053897691 0.347215990428903 no 1175 0.351234741919444 1740 590582 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.381735172108203 0.347310645460458 no 1176 0.351328904313761 1678 364106 SGTC_3316 9136639 10.545 µM 0.380716555673336 0.347690513076749 no 1177 0.351706791385615 1720 4903665 SGTC_777 1315-0167 517 µM 0.379695442553864 0.348071465308402 no 1178 0.352085751792992 1603 4221767 SGTC_2468 5987765 72.9 µM 0.37952793762754 0.348133971936954 no 1179 0.352147931065817 1694 26772094 SGTC_1332 1480-0653 17.5 µM 0.378947347518053 0.348350658567082 no 1180 0.352363481707136 1762 5749438 SGTC_472 calcifediol 10 µM 0.378627964965804 0.348469878968593 no 1181 0.352482076315699 1683 5283731 A vitamin D metabolite. SGTC_2022 5136654 200 µM 0.376546891114849 0.349247076676951 no 1182 0.353255181021423 1673 1713771 SGTC_748 act1.228 77.9 µM 0.375487092252286 0.349643112421048 no 1183 0.353649122140593 1594 4421505 YNR035C ARC35 SGTC_875 0709-0210 25.7 µM 0.375368286104958 0.349687519246266 no 1184 0.353693293722638 1731 6251364 SGTC_2885 9057732 51.95 µM 0.374165262081739 0.350137295892103 no 1185 0.354140683425231 1674 6471414 SGTC_2193 5925765 200 µM 0.373345975731999 0.350443724298582 no 1186 0.354445481183044 1726 877370 SGTC_3153 9100258 49.47 µM 0.372471267436351 0.350770989009902 no 1187 0.354771000392032 1621 25236848 SGTC_1960 st011366 51.8 µM 0.371539251533742 0.351119816759532 no 1188 0.355117963118096 1653 3972846 SGTC_1161 k007-0610 110 µM 0.370597474840018 0.351472425169993 no 1189 0.355468681566692 1708 5843850 SGTC_980 1473-0395 201 µM 0.367894258534569 0.352485239331183 no 1190 0.35647604075047 1640 768876 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.365803790496541 0.353269193288841 no 1191 0.357255745613499 1710 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1540 guanosine 70.6 µM 0.365128033951358 0.353522744603259 no 1192 0.357507917679154 1755 6802 Guanosine is a purine nucleoside SGTC_1460 k062-0059 9.15 µM 0.365124441832298 0.353524092579778 no 1193 0.35750925831656 1619 1373085 SGTC_402 epigallocatechin gallate 10 µM 0.364621102542295 0.353712993546444 no 1194 0.357697130125558 1645 65064 An antioxidant. SGTC_2363 9053361 176 µM 0.361347873276624 0.354942298773904 no 1195 0.358919705077162 1797 6469797 YMR079W SEC14 SGTC_1798 st045719 60.953 µM 0.357534276220968 0.356376452598612 no 1196 0.360345935433054 1773 3980186 SGTC_183 3914-0051 30.55 µM 0.357261157896764 0.356479240644129 no 1197 0.360448152639414 1832 1596232 SGTC_1677 st019204 53.9 µM 0.35705819575323 0.356555632173431 no 1198 0.360524119668969 1621 3945625 SGTC_1253 0550-0034 176 µM 0.3555521539879 0.35712266050732 no 1199 0.361087990293506 1678 5969915 SGTC_720 r052-1644 49.9 µM 0.353586219343878 0.357863314519892 no 1200 0.361824501704238 1692 1422863 YOR257W CDC31 SGTC_198 3454-2873 16.191 µM 0.353565862377607 0.357870986689574 no 1201 0.361832130855748 1721 710957 SGTC_3209 9113616 49.47 µM 0.352040401293412 0.358446068329633 no 1202 0.362403981788662 1888 16649353 SGTC_2483 5729050 27.16 µM 0.35013589925955 0.359164494845951 no 1203 0.363118355151999 1832 2865180 SGTC_2137 5261020 140 µM 0.349015831188686 0.359587245839224 no 1204 0.363538712222578 1698 763655 SGTC_2627 acetyl isogambogic acid 100 µM 0.348451536527516 0.359800294586234 no 1205 0.363750552043619 1616 6857789 A caspase activator and apoptosis inducer. SGTC_2689 tacrolimus 100 µM 0.348348327767874 0.359839265640172 no 1206 0.363789301779498 1685 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1265 0819-1001 68.8 µM 0.34810688303082 0.359930439522014 no 1207 0.363879957663754 1677 3106768 SGTC_1498 4478-3555 97.6 µM 0.347098203496016 0.360311421229101 no 1208 0.364258771553598 1804 3437919 SGTC_2102 5377816 72.7585 µM 0.347078078841844 0.360319023792728 no 1209 0.364266330803886 1829 1379702 SGTC_2045 5106652 78.05 µM 0.346978603181045 0.360356603885235 no 1210 0.364303696763935 1781 673349 SGTC_68 0986-0284 82.829 µM 0.346922289767926 0.360377878664932 no 1211 0.364324850296396 1593 423278 YIL048W NEO1 SGTC_268 camptothecin 39.6153 µM 0.345257400551445 0.361007056227746 no 1212 0.364950434624684 1698 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1603 st002045 67.8 µM 0.343408468948007 0.361706226111496 no 1213 0.365645594597548 1822 5887985 SGTC_208 k072-0098 12.366 µM 0.342612482514346 0.362007369210501 no 1214 0.365945005082973 1726 5948901 SGTC_2767 sibutramine 71.45 µM 0.341720856672466 0.3623447967356 no 1215 0.366280487319071 1837 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2244 6635614 200 µM 0.339413385740656 0.36321853378995 no 1216 0.367149168048408 1719 836499 SGTC_1934 st074720 32.6 µM 0.33922328128943 0.363290549744946 no 1217 0.367220766014293 1633 17250992 SGTC_2539 epi(13)torulosol 80 µM 0.337576783281082 0.363914483142481 no 1218 0.367841070192683 1663 6708597 SGTC_2657 nystatin 74.44 µM 0.337388454939047 0.363985872400653 no 1219 0.367912043307874 1773 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_140 0062-0056 502.533 µM 0.337247054718703 0.364039475810024 no 1220 0.367965334131086 1636 3758964 SGTC_349 k015-0014 24 µM 0.336363649798059 0.364374425970431 no 1221 0.368298328701431 1676 2196908 SGTC_1950 st077106 7.18 µM 0.332757271462647 0.365742885911405 no 1222 0.369658757131451 1682 13831864 SGTC_1758 st042942 75.2445 µM 0.332505446427107 0.365838506375156 no 1223 0.369753813892407 1797 669317 SGTC_1863 st057641 20.1 µM 0.331635544595219 0.366168880823335 no 1224 0.370082238202309 1850 3921635 SGTC_474 dl-dihydrosphingosine 5 µM 0.331250219734233 0.366315252613788 no 1225 0.370227744743535 1789 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3169 9102970 49.47 µM 0.331012473292524 0.366405574094029 no 1226 0.37031753192459 1768 17027839 SGTC_1390 3413-2614 145 µM 0.329451228266409 0.366998885288667 no 1227 0.370907326155131 1727 3421432 SGTC_3269 9137823 49.47 µM 0.329290712425381 0.36705990326452 no 1228 0.370967981725973 1703 17682936 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.327594090669728 0.367705056669521 no 1229 0.371609295282207 1726 61125 An anti-inflammatory. SGTC_520 3584-0023 682 µM 0.326144307124899 0.36825664397198 no 1230 0.372157587942939 1696 1340790 SGTC_2732 terfenadine 20 µM 0.325930068891227 0.368338176508246 no 1231 0.372238632571951 1769 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2636 apigenin dimethyl ether 100 µM 0.324388378227764 0.368925071597807 no 1232 0.372822008645523 1777 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2546 rhodinyl acetate 100 µM 0.323559192938947 0.369240854701269 no 1233 0.373135893299145 1870 6708682 SGTC_456 gingerol 170 µM 0.323252341482448 0.369357736980468 no 1234 0.37325207200735 1774 442793 A herb. SGTC_2771 fluoxetine 41.05 µM 0.320318850585519 0.370475736298992 no 1235 0.374363317338829 1827 3386 A selective serotonin reuptake inhibitor. SGTC_277 nystatin 15.5 µM 0.317960432703315 0.371375360770861 no 1236 0.375257475333628 1699 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2776 terbinafine 19.92 µM 0.317648603580697 0.371494361515286 no 1237 0.375375750870552 1761 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_923 1900-2434 73.3 µM 0.31724655536559 0.371647809945546 no 1238 0.375528263437274 1710 5910570 SGTC_1607 st000305 50.6 µM 0.316378777062555 0.371979081552147 no 1239 0.375857511868729 1824 5457690 SGTC_1475 4092-1048 11.7 µM 0.316284291673522 0.372015156775546 no 1240 0.375893366539885 1745 2881759 SGTC_224 benfluorex 43.875 µM 0.315922321521569 0.372153370062531 no 1241 0.376030734417752 1851 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_820 1582-0060 59.9 µM 0.31460852980411 0.372655161501843 no 1242 0.376529450985509 1724 3848840 SGTC_2699 st077704 54.6 µM 0.313307635083546 0.373152240090828 no 1243 0.37702347499478 1761 645852 SGTC_2575 plumbagin 510 nM 0.312479990333851 0.373468597411934 no 1244 0.377337883838201 1681 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_143 4032-1194 15.74 µM 0.312018288836849 0.373645114372315 no 1245 0.377513312112878 1740 1806963 SGTC_527 4476-4215 268 µM 0.311728070095187 0.373756083898081 no 1246 0.377623596673898 1780 4418754 SGTC_643 k048-0106 28.4 µM 0.311417833926468 0.373874718963665 no 1247 0.377741498990116 1832 6763920 SGTC_138 0850-0259 40.9225 µM 0.311054956744953 0.374013499242669 no 1248 0.377879421478507 1772 6813004 SGTC_3092 9117248 49.47 µM 0.310334223880733 0.374289187773592 no 1249 0.378153404035656 1862 17141857 SGTC_2490 carminic acid 95.39 µM 0.309814029181698 0.374488208129467 no 1250 0.378351191222224 1775 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1990 st072050 59.8 µM 0.308033931445718 0.375169505267139 no 1251 0.379028256631219 1718 17233948 SGTC_2393 9031399 185.94 µM 0.305703631164441 0.3760619701506 no 1252 0.379915154161497 1851 1526623 YDL150W RPC53 SGTC_1015 4130-4525 82 µM 0.304966918366007 0.376344256679778 no 1253 0.380195674086823 1727 1363237 SGTC_1416 3966-0321 25.3 µM 0.304202273041914 0.376637316090727 no 1254 0.380486896608544 1790 582530 YLR208W SEC13 SGTC_1893 st059353 36.1 µM 0.303619307415477 0.376860792380547 no 1255 0.38070897019435 1743 3112488 SGTC_3345 9148410 3.559 µM 0.303365151787064 0.37695823429915 no 1256 0.380805799964253 1871 4903596 SGTC_878 0828-0289 13.7 µM 0.303305100069533 0.376981258953708 no 1257 0.380828679926515 1752 745350 YLR208W SEC13 SGTC_2094 5332512 191.667 µM 0.301668985148216 0.377608735985861 no 1258 0.381452206834158 1870 755774 SGTC_3338 9144300 39.5675 µM 0.301605154342633 0.377633222711829 no 1259 0.381476539139994 1838 4901274 SGTC_3121 9125696 49.47 µM 0.301451210362827 0.3776922806096 no 1260 0.38153522451879 1883 1235365 SGTC_328 k915-0120 63.5 µM 0.300634174240644 0.378005769962564 no 1261 0.381846734505347 1896 6624543 SGTC_885 0865-0106 16.8 µM 0.300510705694206 0.37805315071782 no 1262 0.381893815810748 1713 2793380 SGTC_351 caspofungin 25 nM 0.300209149339691 0.378168879946951 no 1263 0.382008813304289 1827 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2979 9012552 45.46 µM 0.300027336365543 0.378238660166031 no 1264 0.382078152097062 1844 17100905 SGTC_659 k018-0002 107 µM 0.29856286196606 0.378800873315982 no 1265 0.382636802730374 1910 6797879 YHR007C ERG11 SGTC_672 1441-0018 53.7 µM 0.298267928241576 0.378914129735522 no 1266 0.382749340203181 1738 251141 SGTC_205 1486-1330 71.903 µM 0.297930491334134 0.379043720398998 no 1267 0.382878107702193 1807 4118834 SGTC_1957 st077035 62.4 µM 0.296738690275172 0.379501533322012 no 1268 0.383333008068695 1825 705593 SGTC_1765 st044815 90.4 µM 0.295262196790308 0.380068940991861 no 1269 0.383896796207919 1720 645695 SGTC_3002 9075603 71.4286 µM 0.294753323265381 0.380264557962008 no 1270 0.384091162829157 1827 20105405 SGTC_2933 9026794 32.47 µM 0.29394885868601 0.380573866077169 no 1271 0.384398491295055 1833 17586027 SGTC_2245 6637752 200 µM 0.29380532640291 0.380629060753739 no 1272 0.384453332376389 1914 681890 SGTC_1487 3970-0795 2.82 µM 0.290149406154039 0.382035744261889 no 1273 0.385850970008543 1831 3765103 SGTC_479 n-linoleoylglycine 10 µM 0.289299117451003 0.38236313280112 no 1274 0.386176243814564 1790 6433346 An anti-infammatory. SGTC_3228 9131799 49.47 µM 0.289250678297157 0.382381785970015 no 1275 0.386194776388441 1819 17015818 SGTC_1623 st003709 20.3 µM 0.288091906676758 0.382828092264512 no 1276 0.386638193830305 1745 16192618 SGTC_2531 methyl deoxycholate 70.07 µM 0.28789714468405 0.382903121047094 no 1277 0.386712736320784 1758 16667744 Haematoxylin. SGTC_1501 4491-0275 38.4 µM 0.287887308393525 0.382906910429195 no 1278 0.386716501137431 1908 5104718 SGTC_2518 prenyletin 46.28 µM 0.286977899426497 0.383257304091665 no 1279 0.387064621255125 1910 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1059 3448-6867 171 µM 0.285524660629649 0.383817432610045 no 1280 0.387621106961692 1969 3934407 SGTC_1710 st031758 61.5 µM 0.28223164891242 0.385087570149489 no 1281 0.388882945998167 1912 5394341 SGTC_2234 tolnaftate 200 µM 0.282069657520969 0.38515008330886 no 1282 0.388945049362584 1878 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2095 5432005 200 µM 0.280496784838569 0.385757216453773 no 1283 0.38954819591561 1792 783734 SGTC_3243 9134147 49.47 µM 0.279570221556468 0.386115003553894 no 1284 0.389903628074498 1929 24282180 SGTC_1775 st081588 35.1725 µM 0.279444511021587 0.38616355342648 no 1285 0.389951858073051 1776 1426443 YGL099W LSG1 SGTC_636 0kpi-0074 126 µM 0.279401285570031 0.386180247667315 no 1286 0.389968442305091 1808 616434 SGTC_348 k064-0012 10.7 µM 0.279025351689536 0.386325447184844 no 1287 0.390112684630547 1771 5066323 SGTC_2433 5607874 27.82 µM 0.277346722017712 0.386973989806682 no 1288 0.390756943547939 1767 2252428 SGTC_3 0833-0587 95.581 µM 0.276899054216541 0.387147000737699 no 1289 0.390928809419079 1840 5382644 SGTC_360 0957-0399 1.01 µM 0.276092706221395 0.387458687953197 no 1290 0.391238431314537 1907 6752301 YPR165W RHO1 SGTC_2105 5350118 200 µM 0.275415727311374 0.387720424644472 no 1291 0.391498431248085 1797 2133313 SGTC_38 0929-0051 58.268 µM 0.27541350139325 0.387721285323377 no 1292 0.391499286212298 1966 1379719 SGTC_3071 9117417 49.47 µM 0.273354304381588 0.388517735234311 no 1293 0.39229043767023 1960 45595590 YGL055W OLE1 SGTC_1880 MG-132 525 µM 0.273143856534251 0.388599158074563 no 1294 0.392371317688565 1912 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_428 3448-4153 16.5 µM 0.271727125955006 0.389147422184355 no 1295 0.392915921145523 1725 3834874 SGTC_133 0724-0033 378.92 µM 0.270552584831764 0.389602128243627 no 1296 0.393367583916669 1885 280309 SGTC_2179 6298986 200 µM 0.270068988962939 0.3897893891324 no 1297 0.393553589571053 1963 738374 SGTC_2984 9022109 38.96 µM 0.267201034016688 0.390900460242741 no 1298 0.394657190028217 1978 6459207 SGTC_843 0310-0051 143 µM 0.266127331590997 0.391316651820812 no 1299 0.395070573098743 1851 2065037 SGTC_1476 4112-3294 3.34 µM 0.265530840547204 0.391547919181716 no 1300 0.395300277467368 1913 704369 SGTC_709 3807-1509 243 µM 0.264747945000177 0.391851516169942 no 1301 0.39560182006153 1867 1886677 YPL242C IQG1 SGTC_901 1112-0062 60.1 µM 0.264033008230341 0.392128817148734 no 1302 0.395877242040323 1835 1908457 SGTC_1259 0671-0132 43 µM 0.262033531873157 0.392904640215131 no 1303 0.396647795214561 1812 X1259 SGTC_3312 9133330 71.43 µM 0.261931793681676 0.392944127373858 no 1304 0.396687013643877 1914 17617324 SGTC_2236 dapsone 200 µM 0.261597324305065 0.393073951139075 no 1305 0.396815953549239 1964 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_968 1309-0633 340 µM 0.261563534230498 0.393087067365331 no 1306 0.396828980448763 1954 3761976 SGTC_1933 st074711 15.9 µM 0.2596171566247 0.393842793300693 no 1307 0.397579550466536 1963 17250958 SGTC_3296 9122258 64.045 µM 0.259369236472431 0.393939082786655 no 1308 0.397675181734042 1855 4730474 SGTC_976 1348-1067 47.6 µM 0.258506804120112 0.39427409259128 no 1309 0.398007899207711 1834 5310671 YGL099W LSG1 SGTC_1456 k015-0012 13 µM 0.258423502313102 0.394306455127742 no 1310 0.398040040115043 2020 2989616 SGTC_892 0929-0076 29 µM 0.258157952118226 0.394409625560596 no 1311 0.398142503784856 1820 5751038 SGTC_1488 4013-0813 75.9 µM 0.257306936294875 0.3947403084869 no 1312 0.398470919146742 1833 2910057 SGTC_2557 derrustone 83.84 µM 0.25607049878902 0.395220891499047 no 1313 0.398948200617814 1776 629853 An antioxidant. SGTC_629 3448-6466 76.7 µM 0.255820622019419 0.395318033895274 no 1314 0.399044674784924 1861 573744 SGTC_2730 imipramine 71.33 µM 0.255500118711986 0.395442642672771 no 1315 0.399168425966095 1957 3696 A tricyclic antidepressant. SGTC_104 0074-0074 590.992 µM 0.254635119922867 0.395778999679316 no 1316 0.399502465649832 1945 3943124 SGTC_2752 diclazuril 33.15 µM 0.253803478638443 0.396102458735406 no 1317 0.399823692930836 1973 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_747 3448-8087 38.7 µM 0.252226501563218 0.39671600542734 no 1318 0.400432997421303 1822 5168703 SGTC_2360 9040895 200 µM 0.250705789429435 0.397307903695645 no 1319 0.401020792145571 1821 4914414 SGTC_2290 7904846 200 µM 0.250243837964766 0.397487753386681 no 1320 0.401199392825074 1812 2962154 SGTC_3126 9127922 49.47 µM 0.249612091180296 0.397733744077696 no 1321 0.401443673559257 1901 45595682 SGTC_1477 0139-0234 16 µM 0.248733355001248 0.398075975545786 no 1322 0.401783522976378 1908 620880 SGTC_3172 9105863 49.47 µM 0.248232275815003 0.398271160334415 no 1323 0.40197734759979 1917 2348785 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.248229666376351 0.398272176852667 no 1324 0.401978357031271 1832 2724 A muscle relaxant with antifungal properties. SGTC_681 1642-0006 26.6 µM 0.247900080401065 0.398400574060419 no 1325 0.402105858848626 1921 4446530 SGTC_1917 st066507 28.5 µM 0.247830322118054 0.398427751290195 no 1326 0.402132846490533 1822 3156428 SGTC_157 1348-1695 65.819 µM 0.246513503686807 0.398940864759644 no 1327 0.40264237624409 1837 5380510 SGTC_721 1187-1332 279 µM 0.243247940274446 0.400214081168047 no 1328 0.403906665453122 1842 25730 SGTC_2443 5493264 126.67 µM 0.243207187241642 0.400229977174344 no 1329 0.403922449692026 1954 5340055 SGTC_2628 lathosterol 100 µM 0.242710445633498 0.400423748001242 no 1330 0.404114857467724 1880 6710616 SGTC_2373 9071805 200 µM 0.242546860972844 0.400487565085695 no 1331 0.404178225391072 2043 10149009 SGTC_2727 riluzole 51.77 µM 0.241789420732007 0.400783089666686 no 1332 0.404471668382793 1988 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_614 0462-0418 107 µM 0.240320695246535 0.401356292583756 no 1333 0.405040826282016 1914 5188303 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.239702835259231 0.401597489768007 no 1334 0.405280318399064 1872 390807 SGTC_387 norethindrone acetate 66.7 µM 0.238741525034941 0.40197283590642 no 1335 0.405653007653974 1845 541197 SGTC_2300 7976697 71.57 µM 0.237905878007921 0.402299189998468 no 1336 0.405977048201109 1824 2236109 SGTC_1731 st035964 63 µM 0.236664179505689 0.402784249417753 no 1337 0.406458663083231 1829 6739575 SGTC_3167 9103034 49.47 µM 0.234623076506062 0.403581914613255 no 1338 0.407250648493248 1918 5127859 SGTC_2592 piperlongumine 83.33 µM 0.234236941437341 0.403732861836368 no 1339 0.407400518751315 1814 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1744 st037937 38.9 µM 0.234150469039827 0.403766667435622 no 1340 0.407434083063993 1947 1016152 SGTC_3329 9141233 27.5565 µM 0.232698280849714 0.404334494450691 no 1341 0.407997852129208 1980 4909101 YNL103W MET4 SGTC_281 1672-3440 14.9 µM 0.23190867066562 0.40464332836844 no 1342 0.408304474943911 1989 6833000 SGTC_680 0417-1641 114 µM 0.231898468893888 0.40464731889504 no 1343 0.408308436881669 1855 2835990 SGTC_2114 5491910 81.25 µM 0.231878469792843 0.404655141775258 no 1344 0.408316203716009 1961 2849228 SGTC_3343 9148379 18.9835 µM 0.231030549654398 0.404986850591254 no 1345 0.408645534378237 2005 1955036 SGTC_310 1273-0058 1.06 µM 0.230853597363515 0.405056083459473 no 1346 0.40871427047575 1958 2734232 SGTC_2 0422-0095 29 µM 0.230546015621984 0.405176432380843 no 1347 0.408833755511627 1920 6790840 SGTC_169 k015-0017 16.025 µM 0.230090079978234 0.405354844910371 no 1348 0.409010886574088 1987 1840002 SGTC_2679 rapamycin 1 nM 0.228796221554853 0.405861252636461 no 1349 0.409513651833466 1914 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_251 melphalan 456.522 µM 0.228651382974228 0.405917951332047 no 1350 0.409569942236665 1956 460612 A DNA alkylator. SGTC_2667 digitoxin 100 µM 0.228606103779518 0.405935676788352 no 1351 0.409587540030865 2028 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_45 0kpi-0036 14.9 µM 0.228121438140433 0.406125421024687 no 1352 0.409775917111265 1920 2795021 SGTC_1743 st037606 46.3785 µM 0.228058105726183 0.406150216986233 no 1353 0.409800534332942 1890 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2194 5927483 104.545 µM 0.227696595600611 0.406291762947134 no 1354 0.409941059622474 1966 760979 SGTC_1264 0783-0040 158 µM 0.227288093733125 0.406451722830061 no 1355 0.410099865341569 1835 2855798 SGTC_762 1165-0429 115 µM 0.226320273483338 0.406830761121352 no 1356 0.410476165733294 2013 5967793 SGTC_2728 chlorpromazine 9.18 µM 0.225091804641138 0.407312005823423 no 1357 0.410953928176516 1955 2726 A thorazine and dopamine antagonist. SGTC_2288 7946289 167.31 µM 0.224099438168543 0.407700861172652 no 1358 0.4113399648208 1996 1246052 SGTC_2476 5806916 10.51 µM 0.222688721113647 0.408253802203791 no 1359 0.411888890103015 1950 2870194 SGTC_689 0833-0039 98 µM 0.221583029009151 0.408687314239507 no 1360 0.412319247492435 2008 5374726 SGTC_1157 4092-0394 27.6 µM 0.220864083930384 0.408969253190171 no 1361 0.412599131843116 1993 3659885 SGTC_1236 0330-0013 258 µM 0.220484070087704 0.409118297109045 no 1362 0.412747088684224 1895 4617066 SGTC_3282 9108498 15.4605 µM 0.218794209292641 0.409781230430861 no 1363 0.413405178955594 1898 16459645 SGTC_2195 6536160 144.242 µM 0.218274775007579 0.409985056715207 no 1364 0.413607513623846 1877 3834386 SGTC_2100 5377183 190 µM 0.217944082102967 0.410114833459433 no 1365 0.413736340024299 1977 2844202 SGTC_2309 7664088 163.95 µM 0.217765255573189 0.410185016040102 no 1366 0.413806008460691 2070 704922 SGTC_2347 9049783 174.81 µM 0.217037817277043 0.41047053740951 no 1367 0.414089436684108 1981 6467988 YPL169C MEX67 SGTC_969 1313-0238 134 µM 0.216715507126836 0.410597060138884 no 1368 0.414215031126016 1904 5212874 SGTC_343 4130-2827 29.8 µM 0.215761745114076 0.410971513515284 no 1369 0.414586734456262 1866 1118244 SGTC_3009 9080819 71.4286 µM 0.215375417848808 0.411123211304969 no 1370 0.414737317000712 1894 17027216 SGTC_813 k007-0158 173 µM 0.213080927619712 0.412024453986653 no 1371 0.415631920299045 2002 6523916 SGTC_3158 9100007 49.47 µM 0.212446275844238 0.412273818213986 no 1372 0.415879443356488 1872 19297233 SGTC_3159 9100096 49.47 µM 0.209150513460671 0.413569340207416 no 1373 0.417165371270487 1986 25236875 SGTC_2920 7982904 15.77 µM 0.209051917266969 0.413608111682014 no 1374 0.417203854881578 1914 6456808 SGTC_2862 9027634 71.43 µM 0.20508839235888 0.415167401969566 no 1375 0.418751532618842 1847 5012562 SGTC_445 e6 berbamine 66 µM 0.202028700751992 0.41637203113587 no 1376 0.419947143414375 1944 6610268 A calcium/calmodulin antagonist. SGTC_3324 9138759 60.749 µM 0.20188680575416 0.4164279156776 no 1377 0.420002608588532 1982 45595710 SGTC_2196 6573537 42.6665 µM 0.201108815214936 0.416734352842623 no 1378 0.42030674463498 2056 2903087 SGTC_902 1120-0002 2.07 µM 0.200891131991018 0.416820103609111 no 1379 0.420391851004046 1965 3280475 SGTC_1034 k072-0165 12.7 µM 0.198229529191241 0.417868893142647 no 1380 0.421432742463188 2061 5835461 SGTC_529 4076-0302 30.3 µM 0.196948471622772 0.418373895427553 no 1381 0.421933930791712 1926 5816522 SGTC_29 0299-0004 12.984 µM 0.196716929750256 0.418465185315609 no 1382 0.422024530468048 2041 16871 A napthoquinone isolated from Swertia calycina. SGTC_564 3555-0129 330 µM 0.195908316217657 0.418784031352402 no 1383 0.422340964000201 2076 563260 SGTC_1916 st067606 49.2 µM 0.195092460934617 0.419105786976771 no 1384 0.422660282242157 2023 19590279 SGTC_733 4069-0007 56.1 µM 0.194632303463011 0.419287286980843 no 1385 0.422840406069631 2005 5717425 YNL287W SEC21 SGTC_1783 st039459 87.517 µM 0.194542083341881 0.419322874536477 no 1386 0.422875723684814 2067 729761 SGTC_2397 5161689 200 µM 0.19299676245927 0.419932532507066 no 1387 0.423480751804144 2012 2259942 SGTC_2489 cantharidin 73.42 µM 0.192006722401772 0.420323222918073 no 1388 0.423868469843004 1999 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2365 9042475 200 µM 0.190489424302673 0.420922132569997 no 1389 0.424462814824265 1945 6464479 SGTC_3170 9103054 49.47 µM 0.189303067885869 0.421390540136269 no 1390 0.424927645486771 1958 16432970 SGTC_1904 st060225 78 µM 0.18913610576294 0.421456470521616 no 1391 0.424993071924116 2028 66595 SGTC_3333 9141820 12.094 µM 0.186225477495402 0.422606178301418 no 1392 0.426133972630589 1944 1939433 SGTC_2296 7971656 126.45 µM 0.185485385039663 0.422898622840829 no 1393 0.426424171209259 1957 666570 SGTC_2136 5328288 199.296 µM 0.18535765265431 0.422949100080461 no 1394 0.426474260550318 1954 262395 SGTC_454 lyso-paf C-16 6.67 µM 0.184168135563778 0.423419233666216 no 1395 0.426940778008714 1899 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.183469150999295 0.423695544684714 no 1396 0.427214960924638 2094 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2789 5281112 71.43 µM 0.182431972825765 0.424105613916555 no 1397 0.427621868055301 1913 765948 SGTC_2919 7978188 46.38 µM 0.182109906505436 0.424232966050467 no 1398 0.427748237232789 2086 2980291 SGTC_2480 5767542 37.17 µM 0.182068528183469 0.42424932852636 no 1399 0.42776447338453 2020 2867358 SGTC_2177 5811945 192 µM 0.180560144115129 0.424845886716475 no 1400 0.428356420994463 2053 5343475 SGTC_1358 1509-0022 2.48 µM 0.179556942948878 0.42524274306493 no 1401 0.428750204869815 2000 3258434 SGTC_2441 5730946 39.09 µM 0.179376847850888 0.425313994917413 no 1402 0.428820904639536 2034 1774275 SGTC_1448 4255-0083 152 µM 0.17924670832781 0.425365484134296 no 1403 0.428871994816065 2069 5399660 SGTC_1028 k015-0029 4.8 µM 0.179149251121525 0.425404043548062 no 1404 0.428910255348502 2047 4588309 SGTC_828 2074-0507 139 µM 0.178246871394125 0.425761108282086 no 1405 0.429264550508379 2082 X828 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.177820873119724 0.42592969370421 no 1406 0.429431827107623 2076 5357218 A potent inhibitor of glutathione S-transferases. SGTC_760 0568-0725 82.9 µM 0.177375436579502 0.426105986144523 no 1407 0.429606750076131 2111 3916171 SGTC_1376 2910-0861 41.3 µM 0.176740545883403 0.426357285233483 no 1408 0.429856095588957 2043 1112859 SGTC_2749 bexarotene 57.39 µM 0.176472307487624 0.426463466933105 no 1409 0.429961451333877 1956 82146 An retinoic acid receptor inhibitor. SGTC_2778 tioconazole 65.09 nM 0.176193394510542 0.426573879799618 no 1410 0.430071005013012 2029 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_849 0386-0493 241 µM 0.174642212025797 0.427188048871188 no 1411 0.430680388932781 1988 726119 SGTC_2372 9071633 200 µM 0.174574103555542 0.427215019526525 no 1412 0.430707149222113 2139 21321366 SGTC_700 3453-2283 142 µM 0.173984643165295 0.427448457455088 no 1413 0.430938765569637 2063 565664 SGTC_910 3454-3003 490 µM 0.173141107370458 0.427782558417788 no 1414 0.431270256927461 2129 820824 SGTC_2990 9074105 71.4286 µM 0.172037716984998 0.428219658664105 no 1415 0.431703938582938 2065 6502001 SGTC_1065 prochlorperazine maleate 2.48 µM 0.17136816674717 0.428484939201123 no 1416 0.431967141872759 2081 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_34 0469-0683 81.75 µM 0.171145021781651 0.428573357999751 no 1417 0.43205486790464 2056 3690923 SGTC_3003 9075612 71.4286 µM 0.170072417159265 0.428998416032992 no 1418 0.432476592696259 2011 6501993 SGTC_2342 7990637 118.86 µM 0.170056269885586 0.429004815599491 no 1419 0.432482942041838 2003 2033102 YER133W GLC7 SGTC_3328 9140624 29.0385 µM 0.169210576894604 0.429340010828154 no 1420 0.432815505298504 2108 4904392 SGTC_397 arbidol 50 µM 0.169109037021884 0.429380260165413 no 1421 0.432855438396441 2089 131410 A RNA synthesis inhibitor. SGTC_818 4072-2707 53.5 µM 0.167993854768528 0.429822354897399 no 1422 0.433294056779416 2055 882871 SGTC_106 0092-0003 11.579 µM 0.16730913910063 0.430093842234863 no 1423 0.43356340676735 2115 1072148 SGTC_66 0109-0187 42.4 µM 0.166857855958939 0.430272792481975 no 1424 0.43374094712713 2037 759417 SGTC_78 0336-0123 156.75 µM 0.16579625087339 0.430693814080328 no 1425 0.434158648329584 1907 6765896 SGTC_1877 wortmannin 25 µM 0.164974667125336 0.431019699804864 no 1426 0.434481960763054 2120 312145 A covalent inhibitor of PI 3-kinase. SGTC_1008 4106-0037 6 µM 0.163137706302649 0.431748510042767 no 1427 0.435205006060291 2026 2905394 SGTC_1244 0416-0015 52.5 µM 0.161717127549536 0.432312281065146 no 1428 0.43576430812433 2006 96201 SGTC_2113 5491891 107.031 µM 0.160602189869669 0.432754851951818 no 1429 0.436203365011576 1984 789979 SGTC_1794 st048918 76.9 µM 0.160418010320081 0.432827969559598 no 1430 0.436275901579082 2126 672303 SGTC_557 1315-0110 16.2 µM 0.160110308077721 0.432950129683716 no 1431 0.436397090630217 2073 6833801 SGTC_377 3970-0964 33.1 µM 0.160053326071097 0.432972752676087 no 1432 0.436419533745928 2046 16481235 SGTC_637 1181-0519 7.26 µM 0.158419691931505 0.433621431133007 no 1433 0.437063048896703 2089 6252091 YGR060W ERG25 SGTC_303 1348-1668 34.2 µM 0.155834605940304 0.434648273923385 no 1434 0.438081696122287 2053 5380509 SGTC_1407 3909-7909 12.3 µM 0.155723333781547 0.434692483181288 no 1435 0.438125551923359 2028 4411780 SGTC_670 4204-0025 119 µM 0.155574193097157 0.434751739167268 no 1436 0.43818433407399 2083 719039 SGTC_2315 7733312 200 µM 0.15533641567342 0.434846214982017 no 1437 0.438278054234884 2010 726316 SGTC_1558 st069300 45.6 µM 0.154161351030601 0.435313156505875 no 1438 0.438741257623743 2137 24208000 SGTC_861 0443-0273 110 µM 0.153165451216893 0.43570897303006 no 1439 0.439133901043016 2076 6149169 SGTC_3191 9110352 49.47 µM 0.150714306544892 0.43668344454168 no 1440 0.440100543581039 2102 17122424 SGTC_1723 st034307 2.5525 µM 0.149617653594385 0.43711955220303 no 1441 0.440533139705561 2042 867466 SGTC_2412 st077135 33.4 µM 0.149388703768337 0.437210608691567 no 1442 0.440623462399298 2097 13258915 SGTC_1132 3456-3614 2.5 µM 0.149171414067746 0.437297030864533 no 1443 0.440709187929721 2164 3125502 SGTC_998 3996-0085 177 µM 0.148887307607969 0.437410032438481 no 1444 0.440821278321427 2107 715391 SGTC_3132 9126706 49.47 µM 0.147503537773296 0.437960491094662 no 1445 0.441367293767596 2073 850858 SGTC_1057 3448-5381 134 µM 0.147408540202569 0.437998285202636 no 1446 0.44140478252722 2125 5497911 SGTC_3233 9132340 49.47 µM 0.147132273448148 0.438108199179063 no 1447 0.441513808275579 2012 17682950 SGTC_2635 hydroquinidine 100 µM 0.145751045285834 0.438657798489779 no 1448 0.442058961643585 2043 442912 An experimental heart treatment. SGTC_1207 2099-0101 141 µM 0.14498979324241 0.438960756069726 no 1449 0.442359465223495 2143 5837381 SGTC_1454 4239-0054 42.6 µM 0.144342767082562 0.439218282982069 no 1450 0.44261490431955 2146 1340767 SGTC_218 alverine citrate 93.75 µM 0.144307494184824 0.43923232290832 no 1451 0.442628830373836 2134 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_971 1315-0384 26.7 µM 0.143012076387431 0.439748000224545 no 1452 0.443140321827531 2008 6769120 SGTC_496 calpeptin 138 µM 0.14174886430806 0.440250955624616 no 1453 0.443639188229261 2044 73364 A calpain inhibitor. SGTC_2346 9031566 143.75 µM 0.140760779098983 0.440644434876664 no 1454 0.444029464120568 2119 4771086 SGTC_3075 9116269 49.47 µM 0.139903321575185 0.44098594256513 no 1455 0.44436818843253 2070 17015205 YNL244C SUI1 SGTC_867 0518-0118 155 µM 0.139334179817792 0.441212644266571 no 1456 0.44459304085641 2191 6848158 SGTC_1897 st060201 15 µM 0.139181290799993 0.441273546616369 no 1457 0.444653446189168 1976 611878 SGTC_589 1227-0070 34.1 µM 0.137564218016874 0.441917781826221 no 1458 0.445292418243585 2077 2841384 SGTC_2558 carylophyllene oxide 100 µM 0.136435995814526 0.442367352066185 no 1459 0.445738309588317 2179 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2996 9066192 71.4286 µM 0.135575142111508 0.442710432153706 no 1460 0.446078578851217 2026 6472854 SGTC_944 3370-0224 231 µM 0.13515649351002 0.442877293699527 no 1461 0.446244072267859 2047 4580514 SGTC_1014 4130-3005 69.3 µM 0.134867741541228 0.442992388010687 no 1462 0.44635822250011 2003 743608 SGTC_1196 1588-0294 184 µM 0.134305578057061 0.443216475837077 no 1463 0.446580471277663 2026 6144269 SGTC_2475 5812728 15.03 µM 0.134202063526394 0.443257740453422 no 1464 0.446621397108231 2179 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2228 7354201 200 µM 0.13369946946362 0.443458101269353 no 1465 0.446820112352085 2123 753451 SGTC_2493 resveratrol 26.09 µM 0.132881906003806 0.443784056558385 no 1466 0.447143388453802 2098 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1557 sumaresinolic acid 42.3 µM 0.132098044599194 0.444096610856328 no 1467 0.447453371271684 2089 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2352 9027995 87.8 µM 0.129612601248921 0.445087877306781 no 1468 0.448436466498606 2094 2997347 SGTC_826 1683-5028 118 µM 0.128888182839091 0.445376861167172 no 1469 0.448723063700706 2074 722377 SGTC_3108 9121785 49.47 µM 0.12857377050087 0.445502295088105 no 1470 0.448847461057701 2195 17140271 SGTC_2571 chrysanthemic acid 100 µM 0.12712681883748 0.44607962253203 no 1471 0.449420012652581 2012 2743 An insecticide. SGTC_668 1682-0499 62.6 µM 0.126724856720043 0.446240024019849 no 1472 0.449579085813025 2058 682214 SGTC_2497 7-hydroxyflavone 100 µM 0.125351080081664 0.446788290734168 no 1473 0.450122807494605 2184 5281894 SGTC_3156 9099931 49.47 µM 0.124720741454686 0.447039889528148 no 1474 0.450372318154455 2102 18111053 SGTC_1098 clofazimine 15.1 µM 0.124262087155139 0.447222974163425 no 1475 0.450553882328699 2164 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_769 0302-0231 76 µM 0.124240759665261 0.447231487898852 no 1476 0.450562325340589 2160 571869 YER009W NTF2 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.123844227309585 0.447389784348707 no 1477 0.450719306505779 2047 688667 SGTC_3347 9188721 44.724 µM 0.123548014636762 0.447508038465477 no 1478 0.450836577656808 2101 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2221 6807166 181.081 µM 0.12247046901573 0.44793825585293 no 1479 0.451263216111032 2175 674925 SGTC_2572 astragaloside iv 100 µM 0.121652929467432 0.448264704944646 no 1480 0.451586946549308 2073 45006101 An anti-inflammatory agent. SGTC_537 1334-0398 209 µM 0.120000008733659 0.448924834221488 no 1481 0.452241570520187 2221 5846986 SGTC_2096 5468907 200 µM 0.119532440214503 0.449111593456732 no 1482 0.452426770346908 2174 759785 SGTC_1876 myriocin 605 nM 0.118882501769905 0.449371214785144 no 1483 0.452684222501817 2214 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2103 5378138 10 µM 0.117943888028626 0.449746187205269 no 1484 0.453056059146889 2182 244142 SGTC_2448 5185112 27.17 µM 0.117785962463233 0.449809282253955 no 1485 0.453118626223836 2082 5718189 SGTC_2825 7998094 58.44 µM 0.116949724165249 0.450143400607722 no 1486 0.45344994714322 2126 2987815 SGTC_3193 9111931 49.47 µM 0.116108049338544 0.45047972680934 no 1487 0.453783454757008 2115 17087244 SGTC_2677 mitomycin C 100 µM 0.11570189021992 0.450642037323202 no 1488 0.453944404068445 2167 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1167 k781-0610 148 µM 0.11479358109654 0.451005048346214 no 1489 0.454304368482783 2116 4525169 SGTC_3332 9141069 11.198 µM 0.114713797537727 0.451036936271844 no 1490 0.454335988637199 2149 17332883 SGTC_2144 5628481 200 µM 0.114707932614462 0.45103928037926 no 1491 0.454338313059589 2101 2818399 SGTC_1627 st003713 25.6 µM 0.114402124435557 0.451161508932136 no 1492 0.454459514998938 2095 16195070 YER133W GLC7 SGTC_162 k030-0015 37.8 µM 0.114283565348197 0.451208897091822 no 1493 0.454506505044698 2176 1809920 YMR134W ERG29 SGTC_831 k061-1017 217 µM 0.112614792327356 0.451875980437518 no 1494 0.455167978537551 2172 1240153 SGTC_3020 9089140 49.47 µM 0.111533648763203 0.452308234621571 no 1495 0.455596592096884 2121 17217859 SGTC_795 0685-0265 78 µM 0.110806297833037 0.452599070102978 no 1496 0.455884975580456 2246 302754 SGTC_332 4112-0506 40.9 µM 0.110241185131619 0.452825051253668 no 1497 0.4561090501481 2130 2790355 SGTC_226 1,3-diallylurea 8.28947 mM 0.10932295248208 0.453192272989423 no 1498 0.456473171126316 2159 74537 YKL182W FAS1 SGTC_278 4092-0821 23.9 µM 0.107807357401895 0.45379848071684 no 1499 0.457074253273164 2161 877900 SGTC_482 fipronil 114 µM 0.107473605958884 0.453931989133924 no 1500 0.457206631708998 2225 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1785 bathophenanthroline 24 µM 0.106052836788969 0.454500388244419 no 1501 0.457770215412065 2050 72812 An iron chelator. SGTC_2864 9034755 47.6 µM 0.106017552228885 0.454514505530043 no 1502 0.457784213002631 2246 4930451 SGTC_848 0368-0089 85.6 µM 0.106007284190292 0.454518613763619 no 1503 0.457788286403202 2212 762535 SGTC_3240 9133527 49.47 µM 0.105519608690965 0.45471373791445 no 1504 0.457981755680841 2142 17617455 SGTC_2014 4013930 200 µM 0.105410584666268 0.454757361081811 no 1505 0.458025008754192 2243 64556 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.103719526910285 0.455434064018206 no 1506 0.458695964999555 2128 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1102 cgs 12066b 26.1 µM 0.101311888538653 0.456397740446113 no 1507 0.459651439532203 2140 6438352 A 5-HT1B full agonist. SGTC_1160 4092-0570 10.5 µM 0.101128768102538 0.45647104642717 no 1508 0.459724120731555 2117 4994975 SGTC_2863 9028737 58.44 µM 0.100368069415777 0.456775581867866 no 1509 0.460026059322855 2244 6460917 SGTC_1269 0831-0796 3.05 µM 0.100361916150546 0.456778045348211 no 1510 0.460028501787851 2220 927758 SGTC_1168 k815-0004 80.5 µM 0.0989356486155641 0.457349100952989 no 1511 0.460594682121717 2193 642433 SGTC_431 k089-0097 107 µM 0.0980066952795484 0.457721087031274 no 1512 0.460963488450699 2234 5499420 SGTC_960 1222-0186 7.7 µM 0.097125480672756 0.458073991056403 no 1513 0.461313372934877 2166 3126296 SGTC_1436 4092-1007 8.32 µM 0.0949656665515818 0.458939080872606 no 1514 0.462171048878517 2226 2881121 SGTC_3253 9135987 49.47 µM 0.0946542071881522 0.459063848640324 no 1515 0.462294745983546 2206 4182430 SGTC_1100 amiodarone 5.07 µM 0.0927402063088987 0.459830667929494 no 1516 0.463054977309794 2272 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_791 1348-1292 225 µM 0.092000180839198 0.460127189621787 no 1517 0.463348947956719 2216 5437054 SGTC_1223 0764-0573 147 µM 0.091816466854465 0.460200805641 no 1518 0.463421930334579 2227 1609797 SGTC_2731 amoxapine 43.43 µM 0.0912945591088736 0.460409946695376 no 1519 0.463629270569153 2271 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_717 1532-0246 73.2 µM 0.0909329691121351 0.460554850977362 no 1520 0.463772926571149 2150 9561992 SGTC_1951 sophoraflavanone G 9.2 µM 0.0908409873941095 0.460591712747319 no 1521 0.463809470719927 2178 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2582 agaric acid 100 µM 0.089703318196682 0.461047662770345 no 1522 0.464261489517843 2205 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1404 3909-7820 48.3 µM 0.0894577091346872 0.461146103624379 no 1523 0.464359081000627 2245 23741373 SGTC_1012 4112-3522 18 µM 0.0893882291150869 0.461173951858415 no 1524 0.46438668891423 2237 3112398 SGTC_2894 9048625 32.47 µM 0.0889454588506874 0.461351422739683 no 1525 0.464562627878446 2245 4092861 SGTC_1052 3253-3998 198 µM 0.0888530760274279 0.461388452532784 no 1526 0.46459933794434 2238 5450317 SGTC_2058 5236698 133 µM 0.0885222498278287 0.461521060291962 no 1527 0.464730800474889 2197 766665 SGTC_1461 k072-0203 53.8 µM 0.0881649244829146 0.46166429472477 no 1528 0.464872797465413 2243 5418714 SGTC_2822 7994718 71.43 µM 0.0863979666631986 0.462372655309683 no 1529 0.465575031627922 2259 1018011 SGTC_312 4092-0653 6.84 µM 0.085338584667146 0.46279741125016 no 1530 0.465996108636202 2219 1148278 SGTC_160 3453-0671 289.699 µM 0.0842763995328563 0.463223333691235 no 1531 0.466418338040093 2235 5322268 SGTC_3051 9093778 49.47 µM 0.0822519387176973 0.464035232532972 no 1532 0.467223186101691 2277 17217378 SGTC_3215 9129942 49.47 µM 0.0818925983880725 0.464179359740276 no 1533 0.467366060150649 2267 17682944 SGTC_2845 9003024 42.97 µM 0.0815086383675435 0.464333366812234 no 1534 0.467518727657547 2238 2990173 SGTC_76 0433-0009 400.328 µM 0.0809109131626248 0.464573126120013 no 1535 0.467756400487278 2098 2841569 SGTC_2182 6325192 200 µM 0.0805324750988842 0.464724931708851 no 1536 0.467906884355164 2265 736248 SGTC_2927 9011802 47.9 µM 0.0789822438736695 0.465346840496857 no 1537 0.468523373136719 2151 43912568 SGTC_2807 7945238 51.95 µM 0.0775720015313843 0.465912663284722 no 1538 0.469084257396133 2216 17148797 SGTC_367 0335-0881 7.1 µM 0.0769240891749296 0.466172644313289 no 1539 0.469341966966339 2220 23828853 SGTC_1827 berberine 7.24 µM 0.0760473735797939 0.466524457791312 no 1540 0.469690704312229 2198 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2655 perillic acid 100 µM 0.0752582160290392 0.466841157851334 no 1541 0.470004632969304 2191 5702197 An apoptosis inducer. SGTC_1105 epirubicin 18.1 µM 0.075073547109683 0.466915271132969 no 1542 0.470078097381944 2226 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2099 5377090 177.372 µM 0.0746843292012017 0.467071479929439 no 1543 0.470232938166976 2191 2243829 SGTC_676 falcarinol 140 µM 0.0741648888748605 0.467279960114922 no 1544 0.470439591750297 2271 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1399 3562-5772 25 µM 0.0740935854595326 0.46730857882839 no 1545 0.47046795964739 2260 23847490 SGTC_1751 st044839 27.194 µM 0.0734969750363859 0.467548044131332 no 1546 0.470705325568934 2293 5291326 SGTC_414 piperonyl butoxide 100 µM 0.0732595120204681 0.467643359437982 no 1547 0.470799804907402 2229 5794 A potent inhibitor of cytochrome P450. SGTC_221 trifluoperazine 10.304 µM 0.0708858181168714 0.468596237761948 no 1548 0.471744315241848 2265 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_21 0849-0113 22.993 µM 0.0679782000032657 0.469763695358485 no 1549 0.472901494005718 2262 1560156 SGTC_207 4185-0010 4.486 µM 0.0666098051329976 0.47031321950484 no 1550 0.473446169858469 2283 3761753 SGTC_2076 5212012 200 µM 0.0652348434891793 0.470865437703435 no 1551 0.473993509554538 2302 604802 SGTC_1385 3091-4834 14.1 µM 0.0646029250529668 0.471119250446651 no 1552 0.474245077860929 2240 4072814 SGTC_507 nimesulide 162 µM 0.0644678527617735 0.47117350433554 no 1553 0.474298851812763 2282 4495 A COX2 inhibitor. SGTC_634 1611-4317 11.2 µM 0.0636828097039407 0.471488839662013 no 1554 0.474611396414392 2304 2843522 SGTC_899 1083-0020 478 µM 0.0626795608095834 0.471891849686708 no 1555 0.475010836747858 2279 767123 SGTC_2479 5617353 43.85 µM 0.0625014869453702 0.471963385854971 no 1556 0.475081738922877 2276 2731746 SGTC_1060 3448-7350 82 µM 0.0622331082580076 0.472071201154997 no 1557 0.475188598501109 2286 570178 SGTC_3292 9120825 59.784 µM 0.0618307879456812 0.472232828420478 no 1558 0.475348792575793 2307 24824900 SGTC_2333 9017922 200 µM 0.0602130077849447 0.472882797707524 no 1559 0.475992992899594 2288 3163164 SGTC_1864 st057645 30.4 µM 0.0601271735477196 0.472917285029981 no 1560 0.476027173874799 2302 688666 SGTC_793 0488-0545 106 µM 0.0599015380154415 0.473007944056793 no 1561 0.476117027468732 2157 292548 SGTC_1388 3346-4487 254 µM 0.059494099571527 0.473171653960596 no 1562 0.476279282507148 2245 3345614 SGTC_2097 5376186 200 µM 0.0588411857949074 0.473434005975868 no 1563 0.476539301875721 2298 742755 SGTC_856 0433-0016 11.3 µM 0.0572087833070908 0.474089983619785 no 1564 0.477189440776962 2210 3911780 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.0569091721710116 0.474210389433293 no 1565 0.47730877391013 2293 5106787 A p450 inhibitor. SGTC_1276 0871-0068 94.2 µM 0.0551427057880931 0.474920333209182 no 1566 0.478012386791539 2294 3414906 SGTC_3006 9075424 71.4286 µM 0.0549596044504915 0.474993926327746 no 1567 0.478085323051428 2255 7465181 SGTC_1318 1280-3875 124 µM 0.0535805850298717 0.475548216798047 no 1568 0.478634662595125 2269 373245 SGTC_3346 9158254 43.5805 µM 0.0531478257101086 0.475722172209119 no 1569 0.478807062933295 2256 17639500 SGTC_2110 5483698 200 µM 0.0527751554017212 0.475871977468257 no 1570 0.47895552851203 2254 2848765 YHR062C RPP1 SGTC_1121 fusaric acid 630.51 nM 0.0525602466557421 0.475958367604476 no 1571 0.479041145868255 2219 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1872 amphotericin b 148 nM 0.0514008081883469 0.476424464107197 no 1572 0.479503070392538 2291 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1380 2291-0730 164 µM 0.0510905352480726 0.476549199925902 no 1573 0.479626688961241 2245 2999191 SGTC_2301 7769476 200 µM 0.0507967286982186 0.476667318050501 no 1574 0.47974374881721 2257 977820 SGTC_768 0384-0033 77.3 µM 0.0507398820001846 0.476690172187023 no 1575 0.479766398161292 2216 3965305 YMR134W ERG29 SGTC_595 3909-8003 73.7 µM 0.0499677542001053 0.477000599083344 no 1576 0.480074042314706 2266 699517 SGTC_2253 7938677 135.83 µM 0.0491911754475128 0.477312829522018 no 1577 0.480383471863607 2322 2301972 SGTC_2248 tofa 1.1 µM 0.0487144201145177 0.47750452018298 no 1578 0.480573441965193 2284 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1660 st012960 28.1 µM 0.0480488445468639 0.477772139142315 no 1579 0.480838657607277 2259 24207266 SGTC_1442 4112-3290 3 µM 0.0468916667016118 0.478237448540087 no 1580 0.481299784899264 2325 704353 SGTC_97 0535-0701 19.132 µM 0.0465234745687897 0.478385507452887 no 1581 0.481446512170309 2318 2832013 YGL099W LSG1 SGTC_1212 0520-0165 585 µM 0.0458959669320264 0.478637850230346 no 1582 0.48169658435685 2322 5403258 SGTC_3299 9121982 43.1275 µM 0.0455867015484614 0.478762219818948 no 1583 0.48181983439011 2276 17594604 YPL160W CDC60 SGTC_253 dyclonine 31.25 µM 0.0448735406854929 0.479049021897288 no 1584 0.482104053533695 2327 3180 An oral anasthetic. SGTC_3250 9135583 49.47 µM 0.0439262510016777 0.479429997087817 no 1585 0.482481595109359 2344 7699353 SGTC_805 3852-0218 479 µM 0.0437236417328318 0.479511483699935 no 1586 0.482562346928699 2328 6615355 SGTC_3198 9112019 49.47 µM 0.0435936246085887 0.479563775218806 no 1587 0.482614166846801 2306 45595555 SGTC_3239 9133757 49.47 µM 0.0435538732770391 0.479579762856201 no 1588 0.482630010285772 2318 17036923 SGTC_2322 7413319 38.22 µM 0.0434651310569147 0.4796154543184 no 1589 0.482665379814958 2280 1840400 SGTC_1727 st034309 9.9045 µM 0.0433918628120176 0.479644922385817 no 1590 0.48269458206444 2338 870305 SGTC_3213 9129884 49.47 µM 0.0426493978632442 0.479943543773508 no 1591 0.482990508743889 2297 17190742 SGTC_2761 levamisole 97.89 µM 0.0425253218863244 0.479993448565516 no 1592 0.483039963029488 2332 26879 An alkaline phosphatase inhibitor. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.0420072678369672 0.480201819271126 no 1593 0.48324645216841 2285 75037 A free radical scavenger. SGTC_2005 4024620 188 µM 0.0411763059364948 0.480536058446769 no 1594 0.483577671386248 2340 236743 SGTC_1908 st060353 56.5 µM 0.0406532860495335 0.480746440630651 no 1595 0.483786151557181 2340 4227716 SGTC_2945 9067681 61.76 µM 0.040279132540094 0.480896945338282 no 1596 0.4839352950483 2345 16456930 SGTC_1860 st056228 74.6 µM 0.0396300845884283 0.48115803385337 no 1597 0.484194021119884 2240 688679 SGTC_2545 solidagenone 89.61 µM 0.0387337104066109 0.481518626030839 no 1598 0.484551348274725 2345 6708572 An anti ulcer agent SGTC_1409 3909-8004 61.9 µM 0.0379647394125519 0.481827978689799 no 1599 0.484857897810675 2287 2119279 SGTC_1575 cyproterone acetate 48 µM 0.0377237435554629 0.481924932213726 no 1600 0.48495397242421 2299 9880 An androgen receptor antagonist and liver toxin. SGTC_2969 9091408 28.7 µM 0.0374826232141639 0.482021936887961 no 1601 0.48505009753833 2176 4286311 SGTC_301 4119-0100 24.5 µM 0.0371923188519095 0.48213873010551 no 1602 0.485165831522483 2323 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3241 9133421 49.47 µM 0.0365613254719175 0.482392592215676 no 1603 0.485417390350653 2337 17018221 SGTC_1817 st052116 64.4 µM 0.0363764046106033 0.482466991184018 no 1604 0.485491114058891 2332 4361398 SGTC_2203 7227154 166.4 µM 0.0360281407187248 0.482607109395945 no 1605 0.485629960233365 2334 896304 SGTC_2439 5492030 7.2 µM 0.0351946795150247 0.482942447404744 no 1606 0.485962252368289 2339 5722370 SGTC_1692 fluoroquinolonic acid 71 µM 0.0341110602761408 0.483378452974486 no 1607 0.486394294396866 2299 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_921 1561-0023 372 µM 0.0334035903006343 0.483663121699254 no 1608 0.486676373308034 2361 24050882 SGTC_3201 9113999 49.47 µM 0.0330936208726511 0.483787848496222 no 1609 0.486799964885734 2332 16649224 SGTC_1784 st039334 36.3 µM 0.0330762517364135 0.483794837609077 no 1610 0.486806890377149 2340 3496984 SGTC_2077 5212015 200 µM 0.032995452050842 0.483827350409352 no 1611 0.486839107202962 2347 780900 SGTC_1097 itavastatin 7.23 µM 0.0324398925036973 0.484050903642261 no 1612 0.487060624799696 2345 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_951 1171-0579 82.7 µM 0.0322873061171749 0.484112304205696 no 1613 0.487121466089628 2342 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_745 0469-0705 296 µM 0.0316149573198463 0.48438286095486 no 1614 0.487389557568162 2349 3486736 SGTC_2141 5621638 7.665 µM 0.0306825678610516 0.484758071329033 no 1615 0.487761346724497 2342 2856238 SGTC_100 0086-0128 49.5915 µM 0.0306309888074086 0.484778828069675 no 1616 0.487781914122493 2337 93297 SGTC_1982 st072467 71.9 µM 0.0305455539803292 0.484813209336896 no 1617 0.48781598174594 2303 3163533 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.0301608448659209 0.48496802800409 no 1618 0.487969387792331 2338 6708514 SGTC_2832 7992762 51.95 µM 0.0294476137947401 0.485255059891827 no 1619 0.488253799467918 2325 2985177 SGTC_2037 5169046 200 µM 0.0286272114841401 0.485585231088237 no 1620 0.488580954674361 2326 5718022 SGTC_314 1671-0008 2.74 µM 0.0285963338994183 0.485597657977378 no 1621 0.488593268007338 2341 3913060 SGTC_1546 5-methoxyflavanone 78.7 µM 0.028090512173285 0.485801231274509 no 1622 0.48879498063893 2363 147795 SGTC_1135 dihydrocapsaicin 536.708 nM 0.0280530271826042 0.48581631765292 no 1623 0.488809929095558 2344 107982 A Capsaicinoid. SGTC_1323 1348-1351 11.2 µM 0.0269945831726934 0.486242312101385 no 1624 0.48923202723027 2249 6989654 SGTC_1286 0929-0070 131 µM 0.0266757516077751 0.486370636089759 no 1625 0.489359176831181 2323 1420408 SGTC_1248 0469-0687 58.6 µM 0.0266645822135236 0.486375131596347 no 1626 0.489363631190324 2321 4017482 SGTC_2834 9001755 58.44 µM 0.0257039493910785 0.486761777708561 no 1627 0.489746736870251 2273 2989575 SGTC_2853 9015042 58.44 µM 0.0256280653773025 0.486792320879941 no 1628 0.489777000242198 2351 6457456 SGTC_154 3389-1638 511.116 µM 0.0253277260879404 0.486913207631708 no 1629 0.489896779400717 2241 5238686 SGTC_708 3448-5400 146 µM 0.0236718652366013 0.487579713950749 no 1630 0.490557174001985 2362 3462195 SGTC_3135 9127742 49.47 µM 0.0229564313304992 0.48786769658579 no 1631 0.49084251327133 2300 3643468 SGTC_2971 9092186 9.93 µM 0.022608180649342 0.488007879756201 no 1632 0.49098140914104 2346 25236400 SGTC_2267 7931562 200 µM 0.0221368364969393 0.488197614742664 no 1633 0.491169401196675 2366 934880 SGTC_2520 obtusaquinone 4.71 µM 0.0221209393492881 0.488204014031041 no 1634 0.49117574168839 2353 5967872 SGTC_63 0099-0242 26.702 µM 0.0208103759921202 0.488731582664573 no 1635 0.491698460343733 2375 3898502 YLR359W ADE13 SGTC_518 1021-0119 62.6 µM 0.0199870281595149 0.489063032328441 no 1636 0.492026860264494 2303 1097762 SGTC_764 1951-2361 146 µM 0.0188077742660093 0.489537769828611 no 1637 0.49249722597666 2367 5438930 SGTC_3116 9124943 49.47 µM 0.0181847986618326 0.489788569922719 no 1638 0.492745714771596 2370 41905195 YPL160W CDC60 SGTC_2686 alizarin 95.37 µM 0.0180854186196124 0.48982857912694 no 1639 0.492785355153206 2357 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_135 0933-0004 26.348 µM 0.0175935706813763 0.490026592662943 no 1640 0.492981542868704 2354 21230617 YGL099W LSG1 SGTC_574 1315-0397 40 µM 0.0173538618150452 0.49012309818066 no 1641 0.493077158271966 2375 6794277 SGTC_3063 1327-0034 4 µM 0.017099695340521 0.490225424886173 no 1642 0.493178540980262 2359 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2264 7948757 110.76 µM 0.0155039302908904 0.490867889821147 no 1643 0.493815074475896 2384 2971411 SGTC_1594 piperine 70.1 µM 0.0143517782522234 0.491331768223189 no 1644 0.494274665401489 2385 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_582 0987-0078 156 µM 0.0142982460942185 0.491353321581637 no 1645 0.494296019451574 2379 1625765 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.0141478883705375 0.491413859420064 no 1646 0.494355997437729 2377 2346 DNA damaging agent; causes G2/M arrest. SGTC_2840 9008771 71.43 µM 0.0137943720028005 0.491556194865198 no 1647 0.494497016299317 2376 2992978 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.0134271839190542 0.491704036058575 no 1648 0.494643489582004 2352 689007 SGTC_1367 1812-0510 76.9 µM 0.0127926100926064 0.491959537634382 no 1649 0.494896626153013 2377 1142582 YDR527W RBA50 SGTC_908 3448-7491 47.7 µM 0.0117222959258465 0.492390490903289 no 1650 0.495323587631417 2377 1203031 SGTC_175 3793-3120 23.7 µM 0.0104059614297734 0.492920514377268 no 1651 0.495848696937545 2385 5322297 SGTC_667 1498-1044 59 µM 0.00929570668153795 0.493367569378203 no 1652 0.4962916029858 2369 6739982 SGTC_1206 3978-0017 132 µM 0.00838146464137768 0.493735704212091 no 1653 0.496656318531262 2356 3873677 SGTC_1378 2093-0007 380 nM 0.00814980912476174 0.493828985036253 no 1654 0.49674873255417 2375 3618014 SGTC_2859 9028643 45.46 µM 0.00582944542189307 0.494763344634567 no 1655 0.497674400921508 2389 17151580 SGTC_2188 6126565 140.678 µM 0.00525728957560722 0.494993743864882 no 1656 0.497902654569435 2385 874518 SGTC_2591 skatole 100 µM 0.00477017575088313 0.495189899170712 no 1657 0.49809698242509 2389 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3129 9127257 49.47 µM 0.00460307450683567 0.49525718924879 no 1658 0.498163645444258 2392 837894 SGTC_3093 9117344 49.47 µM 0.00430920536342421 0.495375527877686 no 1659 0.498280881106057 2395 24824913 SGTC_947 3447-0010 211 µM 0.00427051059985997 0.495391109963605 no 1660 0.498296317941231 2397 748350 SGTC_3089 9117425 49.47 µM 0.00290948030430539 0.495939190775674 no 1661 0.498839286930205 2396 9401657 SGTC_1479 0549-0158 134 µM 0.00185817026861139 0.496362553925335 no 1662 0.49925869774226 2402 5440202 SGTC_2474 5321570 43.32 µM 0.00142891660035099 0.496535415826686 no 1663 0.499429944946942 2397 2841384 SGTC_3234 9132280 49.47 µM 0.000595372438604802 0.496871088703579 no 1664 0.499762480775687 2403 17612295 SGTC_2769 toremifene 3.73 µM 0.000427160437292528 0.496938828889772 no 1665 0.499829587646232 2403 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3303 9125618 40.5795 µM 0.000197654522417157 0.497031252719034 no 1666 0.499921147254609 2405 22695467 SGTC_2473 5854593 8.94 µM 0.000113630881377998 0.497065089737409 no 1667 0.499954667837157 2404 2872951 SGTC_1729 st035615 45.989 µM -0.00164735687281495 0.497774258623371 no 1668 0.499342799989774 2417 17385451 SGTC_1720 st037298 9.481 µM -0.00209638314284157 0.497955087591361 no 1669 0.49916366474099 2412 597396 SGTC_556 4058-0063 51.5 µM -0.00240531504857328 0.498079498905302 no 1670 0.499040419054721 2411 6615692 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.00250564091796484 0.498119901614102 no 1671 0.49900039494428 2409 17037758 SGTC_3066 9117245 49.47 µM -0.00359871497364854 0.498560099835321 no 1672 0.498564323540746 2413 17176980 SGTC_1629 st005085 44.9 µM -0.00392970224572754 0.498693394018362 no 1673 0.498432279659728 2412 24207091 SGTC_911 3456-4043 236 µM -0.0048514816204449 0.499064610914204 no 1674 0.498064546451438 2422 914281 SGTC_723 4182-0001 115 µM -0.00568580072093974 0.49940060671413 no 1675 0.49773170591618 2419 744821 YLR208W SEC13 SGTC_2873 9040596 71.43 µM -0.00569259740586084 0.499403343867472 no 1676 0.497728994475079 2447 6463863 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.00659552754673281 0.499766971082157 no 1677 0.497368784276815 2421 688788 SGTC_1902 st060212 70.5 µM -0.00702571862929462 0.499940217334861 no 1678 0.497197166846901 2413 688944 SGTC_1855 st056195 39.6 µM -0.00732261356578236 0.499940217334861 no 1679 0.49707872595237 2422 4028379 SGTC_1669 st015249 58.4 µM -0.00749508612428357 0.499870759303218 no 1680 0.497009921245068 2418 722793 SGTC_3275 9138069 49.47 µM -0.00768074638577688 0.499795990333219 no 1681 0.496935855649322 2451 17617007 SGTC_1837 st055472 66.5 µM -0.0078625852749526 0.499722760310522 no 1682 0.496863314619037 2455 676091 SGTC_1849 st056239 19.2 µM -0.00790317303738868 0.499706414838099 no 1683 0.496847122947617 2420 5393181 SGTC_1154 4088-0362 150 µM -0.00824059744012601 0.499570527564224 no 1684 0.496712514472866 2418 6618304 SGTC_632 0781-2353 4.65 µM -0.00881758178525118 0.499338165034367 no 1685 0.496482339397896 2441 6811515 YHR007C ERG11 SGTC_2180 6301957 200 µM -0.00986859204918836 0.498914903916491 no 1686 0.496063065286076 2422 845462 SGTC_381 3461-2219 42.7 µM -0.0100690715833386 0.498834167253684 no 1687 0.495983089497683 2434 2883159 SGTC_401 neomycin 50 µM -0.0109279674246532 0.498488275252037 no 1688 0.495640458525379 2441 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.0118975366016953 0.498097814589748 no 1689 0.495253681591876 2427 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3039 9090270 49.47 µM -0.0127080698171758 0.497771401577636 no 1690 0.494930350101887 2427 17173750 SGTC_5 0352-0601 109.883 µM -0.0135048263632857 0.497450538075031 no 1691 0.494612517536513 2371 762456 SGTC_1911 st060208 74.3 µM -0.0136215709459697 0.497403523752437 no 1692 0.494565947470219 2439 688783 SGTC_1334 1486-0610 236 µM -0.0143241692474715 0.497120580502823 no 1693 0.494285678668705 2495 3742339 SGTC_2844 9010103 25.97 µM -0.0152440475407154 0.496750138674248 no 1694 0.493918740440653 2472 2480525 SGTC_3120 9124077 49.47 µM -0.0155096932160981 0.496643161692897 no 1695 0.493812775677775 2424 18774327 YGL155W CDC43 SGTC_384 k007-0144 5.16 µM -0.0156306244941781 0.496594462078479 no 1696 0.493764536925566 2456 6824886 SGTC_2760 etidronate 98.04 µM -0.0160932378504512 0.496408165902461 no 1697 0.493580004115683 2453 3305 A chelator and antioxidant. SGTC_2092 5303694 80.6725 µM -0.0169597667534515 0.496059213523395 no 1698 0.493234356315698 2437 1963699 SGTC_2289 7946404 165.07 µM -0.0183362914091225 0.495504891461505 no 1699 0.492685287985006 2447 1246120 YPR165W RHO1 SGTC_1165 k072-0275 30.3 µM -0.0183974848456224 0.49548024925456 no 1700 0.492660879453273 2443 6153523 YGL055W OLE1 SGTC_1278 0874-0585 172 µM -0.0200469152552307 0.494816040942841 no 1701 0.492002973555898 2454 766306 SGTC_2407 paclitaxel 400 µM -0.0208908137773374 0.494476217307845 no 1702 0.491666377285046 2606 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2956 9076196 2.52 µM -0.0221040087796493 0.493987691324429 no 1703 0.491182494357351 2442 16423868 SGTC_3152 9099253 49.47 µM -0.0230046491486851 0.49362502976081 no 1704 0.490823282223667 2468 25236131 SGTC_2013 4024628 200 µM -0.0234415423590553 0.493449107508593 no 1705 0.490649034044834 2485 5230760 SGTC_972 1319-0219 195 µM -0.0248291155766267 0.492890386895555 no 1706 0.490095633670811 2468 23903702 SGTC_52 0329-0193 875 nM -0.0250684312074619 0.492794025377534 no 1707 0.490000190256122 2527 3739292 SGTC_887 0885-0007 9.62 µM -0.0253575939380917 0.492677593261511 no 1708 0.489884867678236 2541 5719458 SGTC_2872 9044037 25.97 µM -0.0277339349559445 0.49172077798141 no 1709 0.488937178962807 2464 6465195 SGTC_1969 st069479 40.1 µM -0.0286036842042818 0.491370591809469 no 1710 0.488590336858981 2465 3895485 SGTC_464 bw-b 70c 158 µM -0.0291302121450929 0.491158599665294 no 1711 0.488380370104952 2542 5353454 SGTC_342 k048-0088 23.3 µM -0.0291604071487069 0.49114644254409 no 1712 0.488368329156526 2448 6820570 SGTC_424 splitomicin 100 mM -0.0296979314129616 0.490930025754225 no 1713 0.488153980844418 2510 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_457 grayanotoxin iii 135 µM -0.0299704106528715 0.490820321801641 no 1714 0.488045325721938 2491 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1628 st004252 77.7 µM -0.0302771848232801 0.490696811061828 no 1715 0.487922996051513 2482 692968 SGTC_2848 9016370 25.97 µM -0.0304611205925793 0.490622756874277 no 1716 0.487849650127103 2458 7894410 SGTC_2511 berberine 10.47 µM -0.0306501407739586 0.490546655993681 no 1717 0.487774277179075 2468 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1802 st050112 57.9 µM -0.0314759616106481 0.490214178674785 no 1718 0.487444981249953 2445 4662563 SGTC_562 3772-2733 112 µM -0.0328340652338986 0.489667418006936 no 1719 0.486903456360889 2473 2876874 YIL048W NEO1 SGTC_3062 9077494 49.47 µM -0.0328366891715118 0.489666361651012 no 1720 0.486902410125392 2468 16459633 SGTC_2017 5132927 60.65 µM -0.0329634374673493 0.489615334871379 no 1721 0.486851872230117 2485 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_376 3970-0862 59.1 µM -0.033393942926691 0.48944202172679 no 1722 0.486680219907398 2483 3135186 SGTC_282 k297-0036 65.7 µM -0.0335279019694086 0.489388092820614 no 1723 0.486626807890764 2472 5061378 SGTC_3065 9113888 49.47 µM -0.0335745642482271 0.489369307679209 no 1724 0.486608202809526 2525 16648368 SGTC_2287 7945887 168.79 µM -0.0343973497009338 0.48903807742356 no 1725 0.48628014842754 2467 1245853 SGTC_1384 3089-0840 101 µM -0.0347117470453847 0.488911511889292 no 1726 0.486154796892772 2450 1069836 SGTC_1903 st060211 78.3 µM -0.0351824044307286 0.488722043539445 no 1727 0.485967146387503 2461 688960 SGTC_2118 5526350 200 µM -0.0357779924184678 0.488482286643749 no 1728 0.48572969066796 2531 743594 SGTC_696 1560-0013 611 µM -0.0357904677708987 0.488477264673013 no 1729 0.485724716907909 2509 1650269 SGTC_934 2950-0684 338 µM -0.0359764756838331 0.488402387142149 no 1730 0.485650558246649 2476 1121253 SGTC_1681 tripelennamine 100 µM -0.0368162776007724 0.488064329802621 no 1731 0.485315747599311 2465 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1936 st074407 74.3 µM -0.0371850965745042 0.487915866582115 no 1732 0.48516871080259 2463 809813 SGTC_644 1498-1197 63.3 µM -0.0376635276314066 0.48772328295915 no 1733 0.484977978042494 2506 6741615 SGTC_1825 st052143 62.6 µM -0.0379321820395394 0.487615142320256 no 1734 0.484870876974388 2486 674173 SGTC_2004 4023728 41.89 µM -0.0384518089512016 0.487405981076498 no 1735 0.484663726964182 2481 360084 YDR527W RBA50 SGTC_217 ketoconazole 989 nM -0.0390140550852847 0.487179668563416 no 1736 0.484439591403897 2464 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3356 9151811 4.48 µM -0.0392661298294255 0.487078206029142 no 1737 0.484339105130204 2476 1859254 YPR165W RHO1 SGTC_742 0kpi-0133 140 µM -0.0395081117931195 0.486980806723839 no 1738 0.484242643145976 2505 2728852 SGTC_1086 cerivastatin 2.18 µM -0.0399698927433402 0.486794939064879 no 1739 0.484058564607019 2478 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1151 3909-8316 15.3 µM -0.0401286238605305 0.486731050166518 no 1740 0.483995290817355 2557 800431 SGTC_1122 capsaicin 818.572 nM -0.0414278955200222 0.486208109353661 no 1741 0.48347738723636 2564 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2343 7990716 14.84 µM -0.0420003249478948 0.485977721044259 no 1742 0.48324921953807 2487 6456862 SGTC_2478 5763493 32.33 µM -0.0432853045477639 0.485460566545085 no 1743 0.482737052757698 2496 1365576 YLR208W SEC13 SGTC_1821 st053465 65.6 µM -0.0435767337910264 0.485343280937499 no 1744 0.482620898910696 2514 675086 SGTC_2087 5276107 200 µM -0.0435959471503768 0.485335548571492 no 1745 0.482613241166732 2481 144405 SGTC_3047 9092122 49.47 µM -0.0436135852339611 0.485328450175935 no 1746 0.482606211275854 2497 17173831 SGTC_1853 st056710 91.2 µM -0.0438888741731067 0.48521766154514 no 1747 0.482496491940052 2536 269167 SGTC_1114 scopoletin 1.73284 µM -0.0439099368981473 0.485209185005658 no 1748 0.482488097221366 2476 5280460 A coumarin with genotoxic properties. SGTC_1170 0310-0127 64.8 µM -0.0446933345792603 0.484893917124503 no 1749 0.482175873313134 2527 774975 SGTC_270 tamoxifen 5.46 µM -0.0449036325382286 0.484809287133224 no 1750 0.482092060710113 2487 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1945 st075991 56.6 µM -0.0451559244702003 0.48470775845379 no 1751 0.481991512782963 2522 1084980 SGTC_1848 st056003 16.4 µM -0.0453330166167723 0.484636492669213 no 1752 0.48192093551327 2473 146492 SGTC_1158 4092-0494 91.8 µM -0.0460888460403681 0.484332335788289 no 1753 0.481619718066341 2591 1148199 SGTC_3034 9090421 49.47 µM -0.0464318902914466 0.48419429273136 no 1754 0.481483009569068 2478 17173761 SGTC_75 0159-0059 199.013 µM -0.0482626844534604 0.483457602656123 no 1755 0.480753446685874 2488 5377270 SGTC_1676 st018489 23.4 µM -0.0503600957287281 0.482613698538284 no 1756 0.479917717504762 2546 3696235 SGTC_2502 avocadyne acetate 18.59 µM -0.0509162720648156 0.482389931064992 no 1757 0.479696119547586 2479 3952079 SGTC_2704 st078022 71.1 µM -0.0510750600377768 0.482326046615523 no 1758 0.47963285462717 2514 54697681 SGTC_802 4112-3352 742 µM -0.0527487830246928 0.4816526931085 no 1759 0.478966034934056 2636 704594 SGTC_1667 st014849 34.6 µM -0.0531711029240859 0.481482798285005 no 1760 0.478797789780365 2492 5348460 SGTC_2067 5224629 34.075 µM -0.0538409417812024 0.481213336115411 no 1761 0.478530944991934 2553 2835000 SGTC_1617 st002906 78 µM -0.05388165899286 0.481196956707824 no 1762 0.478514724719564 2509 5150859 SGTC_1178 0988-0033 191 µM -0.0541590608193455 0.481085366475094 no 1763 0.478404218759568 2580 5392207 SGTC_1707 st032323 6.317 µM -0.0563545721229771 0.480202232720135 no 1764 0.477529672800976 2525 3132057 YMR211W DML1 SGTC_528 3492-0019 172 µM -0.0567320911357178 0.480050387201438 no 1765 0.477379305072228 2503 2869262 SGTC_1031 k035-0009 16 µM -0.0569463727185638 0.479964200251068 no 1766 0.47729395706732 2517 5180959 SGTC_2586 curcumin 80 µM -0.0571449776465999 0.479884319499577 no 1767 0.477214853978323 2568 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_533 1222-0222 6.71 µM -0.0580184271897706 0.47953301959175 no 1768 0.476866975237612 2677 3982874 SGTC_1760 st045453 10.4495 µM -0.060471827913522 0.478546351949119 no 1769 0.475889926421699 2496 3323419 YIL048W NEO1 SGTC_316 k060-0003 58.6 µM -0.0610161213098238 0.478327474746143 no 1770 0.475673185014254 2616 6152314 SGTC_1940 st075990 51.1 µM -0.0614440954160208 0.478155377713039 no 1771 0.475502767807087 2738 1084979 SGTC_779 1360-0071 233 µM -0.0615434203978765 0.478115437712661 no 1772 0.475463217722052 2617 7566 SGTC_1235 benzylparaben 21.5 µM -0.062090597940255 0.477895413722961 no 1773 0.475245342154769 2559 7180 SGTC_2359 9039622 200 µM -0.0624134617134066 0.477765591054802 no 1774 0.475116787481832 2539 6463596 SGTC_440 fluspirilene 35.1 µM -0.0626477838749582 0.477671372210954 no 1775 0.475023489045104 2762 3396 An atypical antipsychotic. SGTC_3045 9092950 49.47 µM -0.0630780287453809 0.477498377852806 no 1776 0.474852184986276 2514 44120432 SGTC_2534 helenine 20.12 µM -0.0636838909983328 0.477254777841751 no 1777 0.474610965914189 2526 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_704 1310-0270 142 µM -0.0646114482663411 0.476881849894957 no 1778 0.474241684679863 2581 5718033 SGTC_3118 9124250 49.47 µM -0.0646974184421594 0.476847286277199 no 1779 0.4742074591514 2591 1504786 SGTC_2252 omeprazole 400 µM -0.065251918849341 0.476624358044232 no 1780 0.473986711954492 2596 4594 A proton pump inhibitor. SGTC_2024 5144227 134 µM -0.0655762709704426 0.47649396072381 no 1781 0.47385759073105 2573 3475211 SGTC_895 0964-0006 13.7 µM -0.066064828004526 0.476297553851385 no 1782 0.473663106418859 2505 6738897 SGTC_611 3453-1652 23.7 µM -0.0661042160772463 0.476281719536459 no 1783 0.473647427125738 2517 1560575 SGTC_904 1141-0088 396 µM -0.0672504057431239 0.475820958783674 no 1784 0.473191178968254 2548 1378119 SGTC_1523 st012844 44.7 µM -0.0673995560572813 0.475761003696528 no 1785 0.473131811300954 2646 4274103 SGTC_657 3534-0529 86.7 µM -0.0679282784248587 0.475548473571834 no 1786 0.472921363904998 2588 1049549 SGTC_2955 9076254 12.21 µM -0.06817010426569 0.475451269338942 no 1787 0.472825112466428 2528 16459619 SGTC_2274 7947094 46.08 µM -0.0683688324701276 0.475371389710778 no 1788 0.472746015921873 2528 2971028 SGTC_1030 k029-0042 36.7 µM -0.0685735227961157 0.475289114617989 no 1789 0.472664547494901 2581 6080581 SGTC_419 nsc-638432 893 µM -0.0701173826047816 0.474668595744352 no 1790 0.472050115717811 2581 368090 SGTC_2279 7948423 32.93 µM -0.0703886422533471 0.474559575483164 no 1791 0.471942165497714 2518 1247112 SGTC_3306 9127676 59.7925 µM -0.0716328594181011 0.474059544512045 no 1792 0.471447044601733 2580 41905287 SGTC_2968 9090663 33.37 µM -0.0724022171722791 0.473750372336653 no 1793 0.471140910189654 2643 25236811 SGTC_1883 5-benzylidenerhodanine 20 µM -0.0731452382969024 0.4734517987387 no 1794 0.470845271545422 2568 1273210 SGTC_2207 7258803 200 µM -0.0736195984402851 0.47326119093164 no 1795 0.470656538077492 2538 3666799 SGTC_3028 9087778 49.47 µM -0.0737637103628563 0.473203284963518 no 1796 0.470599201631701 2551 17217395 SGTC_3267 9137951 49.47 µM -0.0742075906314433 0.473024931898125 no 1797 0.470422603028082 2528 16643986 SGTC_201 4262-0159 12.803 µM -0.0742575250462034 0.473004868365998 no 1798 0.470402736890168 2586 1341029 SGTC_2928 9011484 9.79 µM -0.0743303692544916 0.472975599854767 no 1799 0.47037375634644 2606 2994751 SGTC_3266 9136860 49.47 µM -0.0746815022300103 0.472834518080637 no 1800 0.470234062824522 2542 4871271 YPR165W RHO1 SGTC_2784 7567673 72.73 µM -0.0747481640824111 0.472807734388704 no 1801 0.470207542718192 2532 3471247 SGTC_31 0508-1974 57.237 µM -0.0750071187384337 0.472703691616829 no 1802 0.470104523958299 2544 6810525 SGTC_2255 7941087 197.44 µM -0.075374029819952 0.472556277315195 no 1803 0.469958560809553 2530 935561 SGTC_2809 7964133 12.99 µM -0.0759489272011196 0.472325307677218 no 1804 0.469729865479618 2571 1253665 SGTC_2713 st079149 53.4 µM -0.0767667465121278 0.471996758257278 no 1805 0.469404552543156 2596 3103253 SGTC_1994 st072947 40.9 µM -0.0769186429418659 0.471935737720428 no 1806 0.469344133280558 2668 5286565 YDL195W SEC31 SGTC_2459 5811157 9.22 µM -0.0770465151903205 0.471884368799527 no 1807 0.46929327057199 2526 2870684 YBR192W RIM2 SGTC_1222 0366-0074 1.18 µM -0.0809402597629973 0.47032039920788 no 1808 0.467744731161153 2598 286520 SGTC_247 mechlorethamine 29.705 µM -0.0812269243257049 0.470205274715101 no 1809 0.467630743871249 2537 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2974 9094440 9.66 µM -0.0815225301049286 0.470086562037828 no 1810 0.467513204038322 2769 25236134 SGTC_1149 3909-7961 23.3 µM -0.0819743132928832 0.469905135029057 no 1811 0.467333569858566 2569 735261 SGTC_2813 7971799 71.43 µM -0.0821035566951339 0.469853234635205 no 1812 0.467282182420944 2624 2234054 SGTC_563 tetrahydrosecaminediol 614 µM -0.0821763270585112 0.469824012397679 no 1813 0.467253249017464 2595 334274 A psychoactive constituent of the cannabis plant. SGTC_453 enantio-paf c16 10 µM -0.0832836371991685 0.469379372402085 no 1814 0.466813005356854 2568 13871343 A lipid and platelet activating factor SGTC_1657 st012939 43.4 µM -0.0833415609335964 0.469356114193151 no 1815 0.46678997718813 2626 24207257 SGTC_121 0557-0495 61.343 µM -0.0835509747681245 0.469272028797069 no 1816 0.466706723520051 2563 3104427 SGTC_1317 1273-0028 910 nM -0.0842237527241526 0.469001899294655 no 1817 0.466439266669555 2574 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_628 1636-0253 16 µM -0.0842729619820529 0.468982141666623 no 1818 0.466419704563148 2605 4456143 SGTC_1225 1216-0074 20.6 µM -0.0846256956921355 0.468840520525546 no 1819 0.466279485066651 2584 4241466 SGTC_410 α-linolenic acid 100 µM -0.0852241613341773 0.468600248048152 no 1820 0.466041591244953 2669 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_651 3253-0966 34.4 µM -0.085434805385276 0.468515681218133 no 1821 0.465957861804626 2584 781462 SGTC_1340 1486-1359 257 µM -0.0869523946742842 0.467906460013917 no 1822 0.465354676132111 2616 4309068 SGTC_1351 1496-0003 46.5 µM -0.08695511644984 0.467905367451144 no 1823 0.465353594397976 2618 3891978 SGTC_170 4197-0004 226 µM -0.0873706607812154 0.467738564375252 no 1824 0.465188444740515 2662 218692 SGTC_3081 9117243 49.47 µM -0.0878020203793984 0.467565418907236 no 1825 0.465017015969264 2718 45595589 SGTC_753 1322-0200 289 µM -0.0878136839866881 0.467560737281833 no 1826 0.465012380766875 2673 5403907 SGTC_512 prima-1 270 µM -0.0897517556187613 0.466782882492962 no 1827 0.464242243413861 2711 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1357 1503-1303 39.5 µM -0.0899378167408566 0.466708212553138 no 1828 0.464168314747832 2566 292895 SGTC_1502 4534-4282 27.7 µM -0.0902130780957406 0.466597746978223 no 1829 0.464058945943355 2586 3278949 SGTC_2339 9000433 200 µM -0.09155720461144 0.466058370529858 no 1830 0.463524927173418 2626 2988954 SGTC_3203 9113543 49.47 µM -0.092209191546502 0.465796761003902 no 1831 0.463265917680903 2713 17018012 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.0924499851200346 0.465700146399314 no 1832 0.463170263527961 2569 165521 SGTC_1258 0671-0043 57.1 µM -0.0935655644527212 0.465252564343237 no 1833 0.46272713257903 2634 4298767 SGTC_1217 1183-1422 255 µM -0.0939736506867438 0.465088846843265 no 1834 0.462565043897835 2664 2849664 SGTC_1274 0865-0114 173 µM -0.0959319710625218 0.464303283552788 no 1835 0.461787301217815 2632 870624 SGTC_371 0195-0006 7.36 µM -0.0959928056684444 0.464278882488874 no 1836 0.461763143210763 2551 3928593 SGTC_1529 apigenin 74 µM -0.0979126404281462 0.463508896689757 no 1837 0.461000831304245 2651 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1214 0358-0031 63.7 µM -0.0981184470001598 0.463426362157858 no 1838 0.46091911980852 2854 4301366 SGTC_1338 1486-1223 76 µM -0.0983595349088774 0.463329680767162 no 1839 0.460823402643214 2657 3444526 SGTC_65 0798-0905 34.986 µM -0.0990562381259739 0.463050300118467 no 1840 0.46054680902603 2791 3602145 SGTC_593 1203-0218 61.7 µM -0.0997010519534997 0.462791743548641 no 1841 0.460290832683624 2654 3666956 SGTC_991 3996-0057 64.7 µM -0.0999456804819941 0.462693656841752 no 1842 0.460193725052573 2655 715343 SGTC_1175 0741-0056 27.6 µM -0.101457182591001 0.462087652697189 no 1843 0.459593772728047 2692 765927 SGTC_2178 5812956 200 µM -0.101663183634012 0.462005067808216 no 1844 0.459512012945927 2551 5403383 SGTC_2566 crystal violet carbinol 226 nM -0.103381916548182 0.461316099720112 no 1845 0.458829931871058 2747 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_544 k015-0020 52.4 µM -0.103823663637062 0.461139040471022 no 1846 0.458654643542323 2630 3008304 SGTC_1820 st053765 18.6 µM -0.105994148020227 0.460269188426427 no 1847 0.457793497617452 2664 3690829 SGTC_124 0136-0217 7.121 µM -0.107750763282422 0.459565339225734 no 1848 0.457096700304867 2621 3976905 SGTC_815 1582-0027 36.9 µM -0.108270581852622 0.459357079973616 no 1849 0.456890528845379 2671 3128206 SGTC_1311 1190-0148 100 µM -0.108715673807027 0.459178767929827 no 1850 0.4567140048216 2689 1961333 SGTC_1081 sertraline 6 µM -0.110958160071281 0.45828051222707 no 1851 0.455824762608263 2664 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2185 6113692 200 µM -0.111358895296539 0.458120015061549 no 1852 0.455665877035634 2700 874150 SGTC_2202 7226349 200 µM -0.111677615347112 0.457992370401387 no 1853 0.455539514324031 2593 844334 SGTC_974 1326-0144 138 µM -0.112489837485043 0.457667101985325 no 1854 0.455217513556101 2617 5411856 SGTC_212 3807-4682 38.772 µM -0.113226880369479 0.457371964933633 no 1855 0.454925342623039 2679 3125501 YBL034C STU1 SGTC_751 0833-0568 350 µM -0.114494308698514 0.456864498560516 no 1856 0.454422978866471 2667 6954252 SGTC_1181 1222-0449 220 µM -0.114737535100213 0.456767121017269 no 1857 0.454326580836694 2729 658318 SGTC_2703 st077852 53.4 µM -0.114886807790508 0.456707359843443 no 1858 0.454267420855615 2733 6281836 SGTC_2148 5546263 113.568 µM -0.115892491173171 0.456304761083499 no 1859 0.453868873386043 2613 792097 SGTC_2268 7933382 153.85 µM -0.116516899496533 0.45605481825926 no 1860 0.453621446728758 2585 935025 YOR257W CDC31 SGTC_2240 6690706 185.951 µM -0.118591408059493 0.455224543887855 no 1861 0.452799536344188 2593 805876 SGTC_305 1682-2595 20.8 µM -0.119175078304948 0.454990978378439 no 1862 0.452568325274435 2660 226033 SGTC_785 1270-0111 65.3 µM -0.120639088739463 0.454405198502364 no 1863 0.451988453299484 2611 6741994 SGTC_3206 9114350 49.47 µM -0.120794611940654 0.454342976360563 no 1864 0.451926858951606 2667 17087243 SGTC_2338 7999974 200 µM -0.121129869605379 0.45420884938267 no 1865 0.451794085418942 2723 315925 SGTC_3286 9117135 37.221 µM -0.121451934624853 0.454080005321119 no 1866 0.451666541703753 2657 3438150 SGTC_677 0929-0063 136 µM -0.121455638838311 0.454078523456174 no 1867 0.451665074795583 2626 1539583 SGTC_604 1000-0114 314 µM -0.12188425031498 0.453907062410105 no 1868 0.451495344525345 2688 1572745 SGTC_265 mycophenolic acid 32.932 µM -0.122702092322051 0.453579918068762 no 1869 0.451171503477602 2857 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_459 nigericin 15.3 µM -0.123062986359386 0.453435567130072 no 1870 0.451028610521379 2729 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1434 4073-0095 163 µM -0.124813009123047 0.452735677987624 no 1871 0.450335794070719 2645 24133745 SGTC_1458 k015-0034 6.33 µM -0.125562310308523 0.452436053639503 no 1872 0.450039199392128 2663 3598957 SGTC_586 0957-0265 8.15 µM -0.126046590903812 0.45224241792684 no 1873 0.449847522220649 2617 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2958 9077254 16.72 µM -0.128514887972963 0.451255666590137 no 1874 0.448870758510929 2790 16457351 SGTC_1192 1488-0095 21.4 µM -0.129806350280629 0.450739498198158 no 1875 0.448359819314946 2711 915875 SGTC_1370 2001-0092 44.6 µM -0.13175635827816 0.449960282045226 no 1876 0.447588503287427 2730 790957 SGTC_1210 3013-0140 750 nM -0.133539699957767 0.44924783393102 no 1877 0.446883284692722 2793 905973 SGTC_2682 pyrogallin 40.03 µM -0.133878182172051 0.449112628097563 no 1878 0.446749451530004 2665 822798 An ATP competetive kinase inhibitor. SGTC_1216 1165-0504 9.65 µM -0.134163889998027 0.448998507453278 no 1879 0.446636489658038 2663 6304004 SGTC_2421 5690543 90.72 µM -0.134314144340214 0.4489384928605 no 1880 0.446577084510485 2726 3397993 SGTC_2917 7979103 53.79 µM -0.134702417403003 0.44878341423837 no 1881 0.44642358090059 2770 2980565 SGTC_1211 1056-0033 32.3 µM -0.135298051218537 0.448545529687782 no 1882 0.446188112907111 2663 6741922 SGTC_1725 st036284 20.55 µM -0.1365817756645 0.448032898143239 no 1883 0.445680691201357 2889 707914 SGTC_1609 st001574 46.4 µM -0.137083007042405 0.44783276419827 no 1884 0.445482592037778 2664 3960012 SGTC_1997 st073024 93.8 µM -0.137861423482672 0.447521980883661 no 1885 0.445174969412767 2636 686268 SGTC_865 0488-0499 301 µM -0.137896891477422 0.44750782102761 no 1886 0.445160953590278 2635 9634651 SGTC_2988 9073640 71.4286 µM -0.139814517525982 0.446742348942162 no 1887 0.444403271319325 2809 9102229 SGTC_1359 1582-0056 520 nM -0.140537153118105 0.446453940795043 no 1888 0.444117799908691 2752 3661189 SGTC_859 0439-0102 54.6 µM -0.141731169314342 0.445977463987035 no 1889 0.443646176954073 2641 610143 SGTC_2318 6029776 164 µM -0.142007716911449 0.445867117693057 no 1890 0.443536955125159 2792 818325 SGTC_1007 4101-0031 70 µM -0.142040530880233 0.445854024746396 no 1891 0.443523995609178 2772 1146276 SGTC_1885 st057546 99.9 µM -0.142318880058351 0.445742964331987 no 1892 0.44341406709414 2812 702008 SGTC_44 0929-0055 61.211 µM -0.143924569730495 0.445102382768242 no 1893 0.442780016918281 2665 1379590 SGTC_2081 5214970 32.255 µM -0.144277904773781 0.444961440766992 no 1894 0.442640512591612 2686 2063512 SGTC_2050 5263056 171 µM -0.144691061311802 0.444796645363576 no 1895 0.442477398464075 2748 763468 YGL055W OLE1 SGTC_1304 1165-0502 251 µM -0.145117425455318 0.444626591857141 no 1896 0.442309080199768 2695 767425 SGTC_163 TUB2.036 7.546 µM -0.146532924420893 0.444062099431405 no 1897 0.441750350246183 2682 15992207 YJR013W GPI14 SGTC_2129 girgensonine 121.053 µM -0.147334127426968 0.443742634731912 no 1898 0.441434148304368 2726 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_119 0121-0043 24.815 µM -0.148463059484765 0.443292556298351 no 1899 0.440988668550008 2654 1092378 SGTC_3219 9131112 49.47 µM -0.150016451176721 0.442673375568888 no 1900 0.440375817988579 2697 17612988 YMR079W SEC14 SGTC_879 0831-1030 162 µM -0.150064821887393 0.442654097280615 no 1901 0.440356736859325 2686 1549252 SGTC_2156 5649887 115 µM -0.150418414929862 0.442513175865925 no 1902 0.440217256772535 2777 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_957 1187-1561 14.1 µM -0.152614950570203 0.441637929407975 no 1903 0.439350967135015 2661 1538454 SGTC_1247 0448-0043 5.84 µM -0.153355127525367 0.441343057453179 no 1904 0.439059114640277 2779 3089013 YGL099W LSG1 SGTC_536 3852-0578 10.6 µM -0.156185635377703 0.440215740012469 no 1905 0.437943349544489 2857 2869208 SGTC_323 4013-0906 34.3 µM -0.157351332656578 0.439751613512612 no 1906 0.43748398323927 2800 2910086 SGTC_1569 carminic acid 40.6 µM -0.158987501199134 0.439100307007013 no 1907 0.436839360588006 2777 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2200 6600604 21.907 µM -0.159385417472984 0.438941934083979 no 1908 0.436682613608177 2676 2904777 SGTC_2603 homopterocarpin 100 µM -0.159658026942949 0.438833439616685 no 1909 0.436575233158583 2803 101795 A weak amylase inhibitor. SGTC_3317 9138495 8.753 µM -0.159852138756533 0.438756188836275 no 1910 0.436498775662954 2697 17020139 SGTC_2385 9074692 200 µM -0.159898844857997 0.438737601532641 no 1911 0.436480379240962 2725 17046906 SGTC_1038 k292-0204 154 µM -0.160510038546189 0.438494381481825 no 1912 0.436239657267381 2676 4454212 SGTC_1365 1672-3266 55.4 µM -0.160982672407506 0.438306316219534 no 1913 0.436053524025116 2773 6415873 SGTC_2152 5568786 200 µM -0.16115202914279 0.438238931040178 no 1914 0.435986831193859 2660 5399883 SGTC_33 0986-0033 35.816 µM -0.161548468340115 0.438081199255784 no 1915 0.435830720209911 2687 2848082 SGTC_789 1309-1135 70.6 µM -0.162507939545751 0.437699493946604 no 1916 0.435452938264474 2689 3092424 SGTC_475 α-linolenic acid 10 µM -0.16366492430147 0.437239289178383 no 1917 0.434997465750758 2931 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_139 0099-0334 718.624 µM -0.166554063111541 0.436090471096315 no 1918 0.433860470515486 2688 97690 SGTC_2415 st077333 57.7 µM -0.166645270518447 0.43605421271055 no 1919 0.433824585498587 2850 2766255 SGTC_1077 5-fluorocytosine 377 nM -0.167057346091753 0.435890403824595 no 1920 0.433662463595044 2781 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1393 3470-5649 58.2 µM -0.167299271898106 0.435794238245122 no 1921 0.433567288503439 2786 4108395 SGTC_697 0508-1955 564 µM -0.167351722903987 0.435773389455328 no 1922 0.433546654464904 2776 6243113 SGTC_2224 6650123 117.647 µM -0.167693610754076 0.435637496572669 no 1923 0.433412161445188 2692 2908370 SGTC_1974 st069448 26.9 µM -0.167718893824895 0.435627447411026 no 1924 0.43340221580973 2825 6323587 YNR016C ACC1 SGTC_1946 st076057 65.1 µM -0.168743754462335 0.435220135190184 no 1925 0.432999100578797 2700 953009 SGTC_285 1486-1325 46 µM -0.168908260030568 0.435154761833786 no 1926 0.432934400994628 2793 22310230 SGTC_1763 st044482 94.5 µM -0.169386085003474 0.434964887605561 no 1927 0.432746483957317 2838 88505 SGTC_569 4130-2812 160 µM -0.169636124131511 0.434865535050664 no 1928 0.432648155657826 2677 743552 SGTC_532 1548-0774 215 µM -0.170855089250625 0.434381240671725 no 1929 0.432168855450797 2921 5932993 SGTC_2910 7948405 25.97 µM -0.171267536726973 0.434217397702907 no 1930 0.43200670261179 2804 2971328 SGTC_1717 st033143 58.0435 µM -0.173874736435117 0.433181961543852 no 1931 0.430981953790655 2842 674616 SGTC_1698 5-fluorocytosine 1.055 µM -0.176843884937812 0.432003338022248 no 1932 0.429815508537132 2801 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2540 epiandrosterone 100 µM -0.177250610504421 0.431841932441741 no 1933 0.429655771767495 2745 441302 A steroid. SGTC_91 0417-1751 58.384 µM -0.177594926509287 0.43170530245621 no 1934 0.42952055463204 2689 6795624 SGTC_361 000s-0510 1.45 µM -0.17896527031821 0.431161609677852 no 1935 0.428982485829874 2810 660 SGTC_2223 6903751 107.57 µM -0.179343068049571 0.43101173887221 no 1936 0.428834165800027 2830 5598863 SGTC_1144 3486-0183 12.5 µM -0.179522780050319 0.430940451346054 no 1937 0.428763615992363 2747 6744069 SGTC_2693 st077581 40.7 µM -0.183463811534335 0.429377706476768 no 1938 0.427217055512784 2777 25238761 SGTC_2450 5739737 12.93 µM -0.183891339603693 0.429208244011222 no 1939 0.427049349473754 2813 2262825 SGTC_2046 4110841 106 µM -0.184176343988304 0.429095281959113 no 1940 0.426937558390556 2832 44119630 YMR134W ERG29 SGTC_2442 5158906 48.48 µM -0.18520992273999 0.428685669755081 no 1941 0.426532193258214 2884 1893835 SGTC_3231 9132313 49.47 µM -0.186237020262752 0.428278702172459 no 1942 0.426129446897987 2791 4905967 SGTC_579 4491-1009 110 µM -0.186363535680038 0.428228578145641 no 1943 0.426079842884581 2764 1271041 SGTC_2311 7694451 200 µM -0.187878974534431 0.427628268049023 no 1944 0.425485762557342 2820 2163142 SGTC_1861 st057647 17.4 µM -0.188778278650598 0.427272106227473 no 1945 0.425133298427245 2924 688668 SGTC_1321 1326-2144 215 µM -0.188947402717364 0.427205132677753 no 1946 0.425067020332419 2863 3513030 SGTC_631 k072-0230 41.5 µM -0.188950976223934 0.427203717582919 no 1947 0.425065619932413 2850 5773147 SGTC_1383 3049-0032 20.7 µM -0.189069525210163 0.427156773172202 no 1948 0.425019163018996 2891 712864 SGTC_2282 7944268 200 µM -0.19076251120214 0.426486477693388 no 1949 0.424355830492503 2910 2970414 SGTC_1749 st037932 54.2 µM -0.19094178866133 0.426415509661392 no 1950 0.424285599910936 2875 594497 SGTC_451 chloral hydrate 100 µM -0.191596899562023 0.426156200452043 no 1951 0.424028985655967 2858 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2389 9091542 195.52 µM -0.192081455848661 0.425964421538773 no 1952 0.423839200263282 2805 3626624 YOL127W RPL25 SGTC_623 k072-0108 16.9 µM -0.192901367909004 0.425639954571255 no 1953 0.423518106859274 2838 5382803 SGTC_23 0213-0011 39.996 µM -0.194222841388497 0.425117108820212 no 1954 0.423000699280248 2888 627608 SGTC_2887 9044784 58.44 µM -0.195391278253979 0.424654922216853 no 1955 0.422543321986244 2760 6465546 SGTC_1833 st055984 71 µM -0.195582340087618 0.42457935567993 no 1956 0.422468541944256 2802 676288 SGTC_2303 7774051 200 µM -0.195689810675162 0.424536851390781 no 1957 0.4224264800614 2916 2953184 SGTC_1254 0550-0035 264 µM -0.196033231202604 0.424401035505567 no 1958 0.422292077925764 2891 15121435 SGTC_858 0438-0351 2.77 µM -0.197348556137697 0.423880934212579 no 1959 0.421777392054069 2777 2799119 SGTC_3133 9127736 49.47 µM -0.197844114833377 0.423685016417173 no 1960 0.421583514827635 2737 27243420 SGTC_1470 k295-0292 231 µM -0.198137421690438 0.423569067224599 no 1961 0.421468773456859 2864 5045612 SGTC_1924 st058459 75.1 µM -0.198622863492505 0.423377178363153 no 1962 0.421278883728757 2740 688683 SGTC_2850 9015429 58.44 µM -0.198983463092791 0.423234649768765 no 1963 0.421137840234175 2819 6457570 SGTC_3218 9131285 49.47 µM -0.199127994927143 0.423177525738002 no 1964 0.421081311466863 2866 17156417 SGTC_2951 9072950 58.06 µM -0.199150840046278 0.423168496696505 no 1965 0.42107237651552 2765 16488155 SGTC_1450 4112-4260 37.6 µM -0.199754849483156 0.422929789622034 no 1966 0.42083615722863 2852 1633175 SGTC_1314 1222-0010 41.1 µM -0.2008140993244 0.422511237989262 no 1967 0.42042196891833 2810 3526027 SGTC_814 3342-0569 96 µM -0.202030765703325 0.422030592805938 no 1968 0.419946336259635 2754 4346283 SGTC_1683 st010134 710 nM -0.202317006034958 0.421917530141897 no 1969 0.419834452988946 2746 3818134 SGTC_938 3126-1755 342 µM -0.202617417694861 0.421798876836774 no 1970 0.419717037514186 2900 1777771 SGTC_394 menadione 8.33 µM -0.202621240433366 0.421797367019133 no 1971 0.419715543448246 2777 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2622 2-methoxyxanthone 59.94 µM -0.202745521551271 0.421748281937898 no 1972 0.419666970475045 2833 71034 A hepatoprotective. SGTC_111 0083-0039 52.457 µM -0.203750487965949 0.421351413127375 no 1973 0.419274242988675 2743 759313 SGTC_345 1362-0200 395 µM -0.203834614178315 0.421318194670253 no 1974 0.419241371227576 2785 1419823 SGTC_1712 st032288 53.4 µM -0.204666397920354 0.420989782954924 no 1975 0.418916387605919 2821 2883011 SGTC_2140 5586273 200 µM -0.205938401256919 0.420487666493568 no 1976 0.41841951422267 2747 854421 SGTC_233 rapamycin 362 pM -0.206554628217646 0.42024446068331 no 1977 0.41817884872867 2807 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2401 5128683 200 µM -0.206830608053282 0.420135549804674 no 1978 0.418071075600954 2811 708373 SGTC_621 3584-0052 32.1 µM -0.207103788430963 0.420027749708187 no 1979 0.417964401750341 2808 2273927 SGTC_1650 st011916 45.8 µM -0.2102335564033 0.418793137593968 no 1980 0.416742695264158 2855 242528 SGTC_287 k060-0039 29.6 µM -0.210636825510473 0.418634116293736 no 1981 0.41658533716816 2915 5861974 SGTC_2785 7756463 72.73 µM -0.210686994383879 0.41861433410723 no 1982 0.41656576189827 2789 2201551 SGTC_1125 tnp00248 1.32998 µM -0.211707413694045 0.41821201530992 no 1983 0.416167651955182 2959 24207736 SGTC_3238 9133470 49.47 µM -0.211888457746314 0.418140644337431 no 1984 0.416097027768948 2924 3534688 SGTC_501 nsc-95397 161 µM -0.212335898555886 0.41796426631746 no 1985 0.415922495450478 2955 262093 SGTC_2914 7968218 45.32 µM -0.212574561253183 0.417870193905725 no 1986 0.415829407560641 2880 2977111 SGTC_263 alizarin 107.927 µM -0.213134287789488 0.417649587903456 no 1987 0.415611110611539 2762 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1870 st057514 26.5 µM -0.214854190761641 0.416971881969158 no 1988 0.414940500616433 2731 5393161 SGTC_12 0849-0099 9.267 µM -0.214931755147774 0.416941324504806 no 1989 0.414910263192753 2792 6071388 SGTC_120 rhodamine 6G 52.259 µM -0.216094740170999 0.41648321221059 no 1990 0.414456949797595 2778 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1826 st055655 41.6 µM -0.217439649375054 0.415953579477094 no 1991 0.413932867268557 2853 676168 SGTC_1989 st071868 50.2 µM -0.218510375587436 0.415532030593996 no 1992 0.413515737541839 2932 16414057 SGTC_2685 mycophenolic acid 18.85 µM -0.219396781504349 0.415183122810961 no 1993 0.4131704884741 2850 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1464 k208-0027 110 µM -0.220840635470023 0.414614935204404 no 1994 0.412608261046341 2992 X1464 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.223340476284218 0.41363161699795 no 1995 0.411635263611097 2803 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2931 9014674 55.67 µM -0.224489014262854 0.413180018037876 no 1996 0.411188407073723 2824 2996810 SGTC_1108 betulinic acid 729.144 nM -0.224498403777139 0.413176326603821 no 1997 0.411184754411349 2839 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2867 9039098 71.43 µM -0.225204781795005 0.412898640142509 no 1998 0.410909984830688 2780 6463460 SGTC_1076 itraconazole 331 nM -0.225423684998281 0.412812595261297 no 1999 0.410824843903462 2783 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1597 7-benzyloxygramine 47.5 µM -0.225508554475148 0.412779236510394 no 2000 0.41079183562175 2800 260807 SGTC_1240 0356-0016 42.1 µM -0.225565917706846 0.41275668970615 no 2001 0.410769525700479 2865 4305613 SGTC_497 capsazepine 133 µM -0.229446816236652 0.411231962124223 no 2002 0.409260826225474 2817 2733484 A calcium channel blocker. SGTC_761 k216-0224 480 µM -0.230537023673205 0.410803881451979 no 2003 0.40883724870515 2989 1340404 SGTC_3137 9097352 49.47 µM -0.231015957926243 0.410615856756988 no 2004 0.408651202344662 3117 44120435 SGTC_2249 haloperidol 116.36 µM -0.236708267117403 0.408382698691999 no 2005 0.406441560489844 2801 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1280 0880-0253 10.1 µM -0.237019283934182 0.408260768209815 no 2006 0.406320915022483 2854 6836607 SGTC_3046 9092212 49.47 µM -0.237134372784067 0.408215651231672 no 2007 0.406276273554933 2808 25236637 SGTC_1796 st049173 110.4 µM -0.240116166614117 0.407047158181077 no 2008 0.405120100820237 2875 94134 SGTC_286 k060-0067 22.9 µM -0.240483445059276 0.406903287608422 no 2009 0.404977747842817 2858 5985051 SGTC_2348 9022543 33.42 µM -0.241488136785745 0.406509793292257 no 2010 0.404588404966669 2968 3162678 YDL140C RPO21 SGTC_587 k089-0003 57 µM -0.24153183641959 0.406492680174005 no 2011 0.404571472419241 2815 9659696 SGTC_123 0083-0120 66.675 µM -0.241873509720516 0.406358884397751 no 2012 0.404439088472073 2834 16001701 SGTC_3083 9117465 49.47 µM -0.242897635421424 0.405957912786065 no 2013 0.404042348693722 2944 16420915 SGTC_2269 7935389 174.42 µM -0.244437939844398 0.405355029747968 no 2014 0.40344583050614 2806 97605 SGTC_2888 9058547 12.99 µM -0.244808118703241 0.405210173252293 no 2015 0.403302503677226 2846 16476514 SGTC_3025 9087895 49.47 µM -0.247589831928404 0.404122064187327 no 2016 0.402225889385279 2971 17173641 SGTC_93 0109-0045 59.227 µM -0.24824062678016 0.403867602672564 no 2017 0.401974117128882 2795 88733 SGTC_1072 oxiconazole 14.9 nM -0.249256537656096 0.403470461733707 no 2018 0.401581174192362 2845 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2201 6605497 169.863 µM -0.250923735147318 0.402818934998031 no 2019 0.400936536677192 2884 670741 SGTC_2116 5511452 16.8835 µM -0.251590622933463 0.402558396302453 no 2020 0.400678753673639 2977 870744 SGTC_284 0988-0104 32.6 µM -0.252712029551163 0.402120384504716 no 2021 0.400245375660365 2938 4666532 SGTC_2800 7887935 81.82 µM -0.252847976184661 0.4020672932577 no 2022 0.400192846155502 3041 2961002 SGTC_953 1188-0045 9.7 µM -0.252882420553614 0.402053841983066 no 2023 0.400179537207503 2966 6144426 SGTC_2466 5983409 37.09 µM -0.253008450626536 0.402004625489547 no 2024 0.400130841478702 2883 2879657 SGTC_1983 st071813 46.9 µM -0.254320885799438 0.40149219381257 no 2025 0.399623832801184 2917 11838595 SGTC_2902 5787006 60.46 µM -0.254793711953439 0.401307623403373 no 2026 0.399441216081099 2852 591003 SGTC_929 2805-0021 398 µM -0.255983662249871 0.400843216987973 no 2027 0.398981726375333 2935 3098024 SGTC_413 propylparaben 100 µM -0.256426483773744 0.40067043108557 no 2028 0.39881077011305 2852 7175 A pharmaceutical preservative. SGTC_1867 st057372 64 µM -0.256656815531088 0.40058056490424 no 2029 0.398721855602846 2856 688837 SGTC_1296 1068-0102 11.9 µM -0.256840559095207 0.400508879333863 no 2030 0.398650929208955 2956 767053 SGTC_1134 3477-0009 42.5 µM -0.257515205061786 0.400245702241689 no 2031 0.398390539529299 3131 3973534 SGTC_2553 4-methylesculetin 85.09 µM -0.257745307339842 0.400155950479402 no 2032 0.398301738460357 2912 5319502 SGTC_2980 9014342 25.29 µM -0.259106149752211 0.399625259677269 no 2033 0.397776669989889 3041 2996599 SGTC_2662 daunorubicin 22.37 µM -0.25986171753359 0.399330689168913 no 2034 0.397485221004383 2843 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3179 9107801 49.47 µM -0.261667234343943 0.398627011168573 no 2035 0.396789001886344 2870 4818259 SGTC_289 k017-0060 526 µM -0.262081794719959 0.398465487775258 no 2036 0.396629191032367 2871 5512909 SGTC_612 0302-0167 22.4 µM -0.263005280868428 0.398105736366465 no 2037 0.396273254412946 2941 235821 SGTC_2960 9079389 5.97 µM -0.263634555776596 0.397860646890087 no 2038 0.396030764290134 3034 16457355 SGTC_1401 3807-4679 7.6 µM -0.263648303409403 0.397855292922834 no 2039 0.396025467109544 2861 3291456 SGTC_3024 9090631 49.47 µM -0.263677275133564 0.397844010049726 no 2040 0.396014303908374 2972 25236383 SGTC_223 busulfan 5 mM -0.264020183214382 0.397710472941873 no 2041 0.395882183219886 2962 2478 A DNA alkylator. SGTC_409 arachidonic acid 100 µM -0.264523723192063 0.397514403421966 no 2042 0.395688193584282 2889 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1700 st030840 7.9285 µM -0.265017519831872 0.397322152927314 no 2043 0.395497982678214 2971 5499307 SGTC_1611 st001856 99.4 µM -0.265513777075239 0.397128969571282 no 2044 0.395306849022161 2901 647478 SGTC_1048 3161-0300 24.5 µM -0.267075805094688 0.396521067187026 no 2045 0.394705397953716 2866 2165101 SGTC_2208 7283366 200 µM -0.26783927590571 0.396224034763768 no 2046 0.39441151852709 2970 898663 SGTC_663 1486-0733 13.9 µM -0.270041425107621 0.395367614773372 no 2047 0.393564192198936 2877 722445 YPR165W RHO1 SGTC_2673 kobusone 100 µM -0.271668325120489 0.394735234441542 no 2048 0.392938529232812 2890 6710676 An epoxy ketone and protein crosslinker. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.271671889858981 0.394733849122088 no 2049 0.392937158631113 2933 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3168 9103419 49.47 µM -0.272058414539576 0.394583646800469 no 2050 0.392788552134046 2935 16649256 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.272793931619282 0.394297870386147 no 2051 0.392505812289477 2879 66535 A nucleotide analog. SGTC_1414 3917-0015 5.4 µM -0.276398119225058 0.392898331280786 no 2052 0.391121150560184 2985 6618702 SGTC_1804 st050076 49.1 µM -0.278028014524207 0.39226588114213 no 2053 0.390495426872316 3023 3895976 SGTC_716 1683-5115 658 µM -0.279274615413285 0.391782353065702 no 2054 0.390017042771989 2870 723597 SGTC_3162 9099653 49.47 µM -0.281244447671307 0.39101864095062 no 2055 0.389261457770822 3000 25237511 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.281950323750781 0.390745071956316 no 2056 0.388990800699218 2874 16486 A toxic proline analog. SGTC_2133 5320837 200 µM -0.283392389958671 0.390186353657425 no 2057 0.388438030661633 3061 2841355 SGTC_2993 9054257 71.4286 µM -0.284709580949152 0.389676215484014 no 2058 0.387933324889649 2898 6470217 YGL055W OLE1 SGTC_2669 eugenol 100 µM -0.285305295896936 0.389445561908009 no 2059 0.387705127930867 2985 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_961 1252-1571 372 µM -0.285637818194455 0.389316830251737 no 2060 0.387577767465546 3088 6813498 SGTC_2819 7996655 46.38 µM -0.286240220279431 0.389083649110055 no 2061 0.387347070265312 2976 6456960 SGTC_1641 st009299 47.1 µM -0.286325706855139 0.389050561726431 no 2062 0.387314335363145 2935 4046054 SGTC_946 3434-1334 87.4 µM -0.286551673588159 0.388963105694074 no 2063 0.387227811029116 3066 4047976 SGTC_3144 9087057 49.47 µM -0.287650820178826 0.388537782684102 no 2064 0.386807019643977 3019 17249618 SGTC_1778 st046819 58.9 µM -0.28915048156007 0.387957693052341 no 2065 0.386233111974427 2927 671715 SGTC_1705 st027868 56.3335 µM -0.292832213088061 0.386534611133646 no 2066 0.384825202258958 3001 292948 SGTC_318 1488-0629 67.2 µM -0.292870973759864 0.386519637235084 no 2067 0.38481038805336 2992 3662576 SGTC_3242 9133940 49.47 µM -0.293370605675997 0.386326636168181 no 2068 0.384619445384837 3073 17248444 SGTC_1131 3454-3128 32.3 µM -0.293709169423176 0.386195869542558 no 2069 0.384490073507552 3074 710982 SGTC_2066 5222451 176 µM -0.29381339772787 0.386155615076458 no 2070 0.384450248408177 2906 2281147 SGTC_3061 glucosamine 200 µM -0.294968632367431 0.385709529049193 no 2071 0.384008920950378 3021 91431 and experimental redox chemotherapeutic SGTC_334 1502-1024 68.5 µM -0.295739748851385 0.385411851704856 no 2072 0.383714419526191 3006 3296216 SGTC_2145 5634607 200 µM -0.297838448815842 0.384602024003601 no 2073 0.382913233804633 2930 308662 SGTC_352 k048-0007 5.11 µM -0.297911984820422 0.384573657689529 no 2074 0.382885170248812 3019 6811911 SGTC_836 0330-0104 1.35 µM -0.299128640944898 0.384104425697622 no 2075 0.382420946935532 2939 46494820 SGTC_378 3970-0959 8.33 µM -0.300706771496683 0.38349603569316 no 2076 0.381819052371282 3061 6615653 SGTC_42 0133-0086 60.653 µM -0.301280066047131 0.383275094155714 no 2077 0.381600470078518 2879 162923 Model of phenazepam hydroxylation. SGTC_992 3909-8734 162 µM -0.302010081611262 0.382993808980064 no 2078 0.381322188791494 2979 4288319 SGTC_2330 7979373 200 µM -0.303347813945961 0.382478522251192 no 2079 0.380812405713373 2925 1863007 SGTC_2944 9067346 25.62 µM -0.305001842231494 0.381841687834431 no 2080 0.380182374617273 3117 6473075 SGTC_2153 5569715 200 µM -0.305571125021849 0.381622576269594 no 2081 0.379965604192747 2959 2054701 SGTC_2411 st077133 39.94 µM -0.305901290578538 0.381495516039791 no 2082 0.37983990164751 3232 1403142 YNL221C POP1 SGTC_2897 9048598 12.99 µM -0.309114202213639 0.380259734473986 no 2083 0.378617328044205 2960 6467404 SGTC_750 4073-0104 132 µM -0.311518431497445 0.379335794314486 no 2084 0.377703266587978 3025 22330957 SGTC_1525 8-methoxypsoralen 92.5 µM -0.312828731354913 0.378832538508583 no 2085 0.37720539284407 3194 4114 Related to psoralen; DNA damaging agent. SGTC_3087 9117406 49.47 µM -0.313389347846224 0.378617281385747 no 2086 0.376992438057151 3071 42546093 SGTC_1801 st050089 28.441 µM -0.314138110920522 0.378329841295106 no 2087 0.376708072604066 2949 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3281 9140613 49.47 µM -0.318251859251458 0.376751833368985 no 2088 0.375146949011856 2993 16013766 SGTC_92 0063-0024 660.874 µM -0.321399617839366 0.375545760523374 no 2089 0.373953786345111 2936 3594437 SGTC_2712 st079126 47.7 µM -0.321700544213745 0.375430523166318 no 2090 0.373839782763271 2959 3152970 SGTC_450 aminopyrene 156 nM -0.322626265899681 0.37507609514764 no 2091 0.373489149641627 3099 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_423 5-fluorouracil 457 µM -0.322682896135371 0.375054416735484 no 2092 0.373467703354858 2892 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3105 9121040 49.47 µM -0.322691536324382 0.375051109251222 no 2093 0.373464431286188 3000 41448907 SGTC_2839 9003951 25.97 µM -0.323300184573126 0.374818140433356 no 2094 0.373233957114531 3082 2990634 SGTC_1620 st003704 16.5 µM -0.323873879876535 0.374598592168278 no 2095 0.373016759936412 3080 2834414 SGTC_3319 9138450 16.7555 µM -0.324773670710673 0.374254331834749 no 2096 0.372676186487678 2972 2029690 SGTC_2619 obliquin 87.91 µM -0.325198579853677 0.374091796255062 no 2097 0.372515391717225 2949 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2499 avocadenofuran 51.48 µM -0.327457434421938 0.373228119117093 no 2098 0.371660966118941 2959 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_231 b-estradiol 524 µM -0.327711933083159 0.37313085091437 no 2099 0.371564739966327 2978 450 A steroid. SGTC_1473 k844-0725 134 µM -0.328001340253018 0.373020250667629 no 2100 0.371455324630065 3022 54682906 SGTC_421 streptovitacin 30 mM -0.329840070969868 0.372317803569131 no 2101 0.370760403949313 3154 91467 include heat shock SGTC_1664 st014217 9.02 µM -0.330331017353568 0.372130319899264 no 2102 0.370574929311692 3037 3982782 SGTC_269 exalamide 29 µM -0.331923038969035 0.371522563937395 no 2103 0.369973686562227 3001 3316 A derivative of salicylamide. SGTC_2742 clothiapine 36.27 µM -0.33284426638565 0.371171030499516 no 2104 0.369625920882658 3043 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2934 9036370 36.88 µM -0.333098839723864 0.371073906171273 no 2105 0.369529837594802 3089 6462800 SGTC_293 4049-0273 38.5 µM -0.333858121826313 0.370784275122146 no 2106 0.369243311136583 3034 1380311 SGTC_2729 fluphenazine 10.66 µM -0.334706677957027 0.370460676776934 no 2107 0.368923181728575 2982 3372 An atypical antipsychotic. SGTC_2447 5741742 33.78 µM -0.335232783623504 0.37026009147896 no 2108 0.368724746810906 3085 1776504 SGTC_1822 st052468 42 µM -0.33651459677043 0.369771529685605 no 2109 0.368241423063399 3058 2873678 SGTC_101 0490-5701 117.494 µM -0.336660701393365 0.369715855382083 no 2110 0.368186345700021 3055 4661669 SGTC_1777 st045864 34.765 µM -0.33688234635531 0.369631401059037 no 2111 0.36810279691053 3066 4691462 SGTC_2841 9004761 38.96 µM -0.337224792179887 0.369500929834992 no 2112 0.367973724653836 3012 2991039 SGTC_694 1315-0438 43.2 µM -0.337887954136484 0.369248309096708 no 2113 0.367723812733579 3031 6793154 SGTC_1368 1852-0141 284 µM -0.338262447557626 0.369105676865969 no 2114 0.3675827099937 3113 2838987 SGTC_2773 thioridazine 9.09 µM -0.343274596097048 0.36719845602096 no 2115 0.36569594518257 3036 5452 An antipsychotic. SGTC_3184 9108758 49.47 µM -0.344470939357206 0.366743705903368 no 2116 0.365246073643097 2954 902885 SGTC_2400 5203494 178.7 µM -0.345930437584765 0.366189179394862 no 2117 0.364697496668272 3008 6777674 SGTC_3274 9138298 49.47 µM -0.346969587327491 0.365794531625552 no 2118 0.364307083445285 2973 17015756 SGTC_1646 st011709 75.6 µM -0.347058965280704 0.36576059433659 no 2119 0.364273510314907 3126 5757843 SGTC_780 0109-0199 192 µM -0.347769778982032 0.365490731976318 no 2120 0.364006543744171 3191 610414 SGTC_3076 9116187 49.47 µM -0.348536858374072 0.365199582877747 no 2121 0.36371851900267 3117 27241210 SGTC_2610 ononetin 44.17 µM -0.349014298882012 0.365018406981895 no 2122 0.363539287403834 3064 259632 SGTC_2639 lactacystin 53 µM -0.350114080690059 0.364601183914907 no 2123 0.363126542001366 3168 3870 A proteasome inhibitor. SGTC_2026 5148700 152 µM -0.350370953040162 0.364503757601202 no 2124 0.363030161315893 2996 79838 SGTC_412 gemfibrozil 100 µM -0.350645629504944 0.364399588241882 no 2125 0.362927109972223 3086 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1927 st060202 13.8 µM -0.351646766992632 0.364019997828236 no 2126 0.362551593730397 3114 688887 SGTC_666 0272-0154 136 µM -0.35169684854679 0.364001012450041 no 2127 0.362532812129849 3062 6870312 SGTC_2505 galangin 7.89 µM -0.352721268274156 0.363612739264976 no 2128 0.362148706562529 2964 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2403 6032726 181.2 µM -0.353488520289668 0.36332202888346 no 2129 0.361861116741455 3096 2881040 SGTC_2388 9080168 200 µM -0.353567422924803 0.363292137280156 no 2130 0.361831546009735 3002 15943073 SGTC_767 0929-0023 86 µM -0.354556019038426 0.36291768652686 no 2131 0.361461114914481 3081 1204563 SGTC_213 1246-0773 967 nM -0.355836523554746 0.362432864374246 no 2132 0.360981497542574 3075 6251622 SGTC_1695 st026914 34.495 µM -0.356521670602661 0.362173545837394 no 2133 0.360724963042487 2998 3289191 SGTC_1968 st069590 43.6 µM -0.356955604888309 0.362009340507764 no 2134 0.360562520664936 3156 6384066 SGTC_256 clotrimazole 625 nM -0.357447872683296 0.361823091907856 no 2135 0.360378271723819 3102 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2965 9082772 38.63 µM -0.359570721917792 0.361020291200232 no 2136 0.359584090808051 3227 16459634 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.359972043760643 0.360868591447057 no 2137 0.359434019968991 3430 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2701 st077767 14.721 µM -0.360055225687271 0.360837151396272 no 2138 0.359402917517127 3072 5721188 SGTC_2747 doxorubicin 7.63 µM -0.360614404569307 0.360625824465925 no 2139 0.359193859816886 3058 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1055 3448-0672 86 µM -0.361519985321909 0.360283674364253 no 2140 0.35885538383648 3180 748378 SGTC_2367 9070478 135.38 µM -0.36312096543602 0.359679059575146 no 2141 0.358257261922573 2996 572802 SGTC_2463 5473429 200 µM -0.363358590272748 0.359589349747118 no 2142 0.358168515509598 3086 5399405 SGTC_3085 9117376 49.47 µM -0.364138531231815 0.359294955254581 no 2143 0.357877282647551 3131 16480349 SGTC_1109 tnp00067 928.257 nM -0.364811640753876 0.359040952209022 no 2144 0.357626007521197 3066 676295 SGTC_2780 5215298 71.43 µM -0.364834926721785 0.359032166184611 no 2145 0.357617315857278 3187 2834131 SGTC_2950 9072895 21.46 µM -0.364892284257892 0.359010524940911 no 2146 0.357595907037381 3179 17332245 SGTC_596 1155-0152 116 µM -0.365252807765838 0.358874508242116 no 2147 0.357461351148418 3078 280313 SGTC_3265 9137266 49.47 µM -0.365672586062369 0.358716158707203 no 2148 0.357304702298518 3122 17224265 SGTC_2544 sphondin 68.51 µM -0.366103244033067 0.358553730355609 no 2149 0.357144018462878 3235 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1155 4088-0394 48.2 µM -0.366340479311821 0.358464264857818 no 2150 0.357055513854313 3018 2326248 SGTC_678 1218-2179 85.9 µM -0.368152432902283 0.357781202600352 no 2151 0.356379788142038 3120 6820081 YOR116C RPO31 SGTC_2438 5259590 200 µM -0.368738412600957 0.357560399859549 no 2152 0.356161357052581 3147 1201127 SGTC_1789 tunicamycin 25 nM -0.369723794498845 0.357189206066181 no 2153 0.355794150351554 3162 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1484 3473-2379 286 µM -0.37078656606753 0.356789010999594 no 2154 0.355398253999754 3120 671917 SGTC_2568 diosmetin 100 µM -0.371464460722329 0.356533826666901 no 2155 0.355145810798873 3222 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_987 1497-1013 404 µM -0.372649833382016 0.356087763422432 no 2156 0.354704539162686 3101 1676435 SGTC_1071 trifluoperazine 6.31 µM -0.372651281999656 0.356087218418768 no 2157 0.354704000013521 3207 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2168 5727979 200 µM -0.373066861235232 0.355930879985979 no 2158 0.354549340995109 3076 695210 SGTC_808 0711-0032 135 µM -0.373523946366314 0.355758955255961 no 2159 0.35437926312595 3165 4252555 SGTC_2214 7179297 48.276 µM -0.373569753909432 0.35574172715121 no 2160 0.354362220090938 3083 769744 SGTC_1605 st000082 49.1 µM -0.373773572199191 0.355665075164366 no 2161 0.354286391525846 3172 1114022 SGTC_1881 5652484 16 µM -0.374761601212661 0.355293579960503 no 2162 0.353918887092625 3190 2255129 SGTC_1319 1306-0155 43.7 µM -0.375665401823089 0.354953874697635 no 2163 0.35358283115603 3083 3122360 SGTC_1527 coumarin 137 µM -0.376554557393615 0.354619786445591 no 2164 0.353252331937327 3239 323 A hepatotoxic, DNA x-linker. SGTC_1630 st005209 31.3 µM -0.377437659229239 0.35428808345905 no 2165 0.352924192402439 3187 3367314 SGTC_1871 st057448 67.3 µM -0.377865082093598 0.354127578293406 no 2166 0.352765411541382 3281 691747 SGTC_1070 indatraline 8.81 µM -0.379311791219876 0.353584504780623 no 2167 0.352228172317254 3089 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2508 celastrol 40.54 µM -0.379595538179359 0.353478025216681 no 2168 0.352122836682316 3107 122724 Celastrol is a natural product and antioxidant. SGTC_259 usnic acid 108.925 µM -0.381355284862108 0.35281791479988 no 2169 0.351469818002853 3275 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_273 hydroxyurea 18.1 mM -0.381497882270538 0.352764443496315 no 2170 0.351416921158668 3056 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2491 paeonol 100 µM -0.38169646139085 0.352689984965845 no 2171 0.35134326256075 3021 11092 Increases levels of cortical cytochrome oxidase. SGTC_2034 5197015 53.07 µM -0.382926154202203 0.352229029423179 no 2172 0.350887259229313 3225 780676 SGTC_2154 5570129 200 µM -0.38340231830056 0.352050595546433 no 2173 0.350710742336456 3140 673366 SGTC_1709 st033179 39.1045 µM -0.383639566678166 0.351961703166319 no 2174 0.350622804961996 3068 573381 SGTC_295 k015-0027 31 µM -0.384628000195157 0.351591443353081 no 2175 0.350256522996549 3149 3887424 SGTC_1865 st057639 52.2 µM -0.384747927059271 0.351546529213178 no 2176 0.350212091387002 3064 688818 SGTC_333 3486-0131 40.1 µM -0.386617309371976 0.35084668997766 no 2177 0.34951977078704 3216 6744690 SGTC_2801 7907800 81.82 µM -0.387292315807168 0.350594112481683 no 2178 0.349269906814085 3176 6620925 SGTC_2569 tetrandrine 100 µM -0.387502091585909 0.350515630910192 no 2179 0.349192268394024 3120 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2155 5570423 76 µM -0.38827801443368 0.350225397172715 no 2180 0.348905152716785 3082 797402 SGTC_1403 3909-7815 62.9 µM -0.389569978575899 0.349742332415917 no 2181 0.348427277617158 3052 6615483 SGTC_1402 3909-7673 35.9 µM -0.391282112168751 0.349102541222814 no 2182 0.347794359724883 3075 5328014 SGTC_838 0109-0203 71.4 µM -0.391636814293547 0.348970049444843 no 2183 0.347663291294147 3101 759422 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.391916120089248 0.348865733390506 no 2184 0.347560095893213 3188 616764 SGTC_3101 9120531 49.47 µM -0.392353750488753 0.348702308710985 no 2185 0.347398426854647 3292 24824904 SGTC_2149 5554786 194.827 µM -0.394799345817412 0.347789565519029 no 2186 0.346495488876316 3106 745063 YPR165W RHO1 SGTC_2525 harmine 47.85 µM -0.395240917711531 0.347624856189901 no 2187 0.346332548905616 3107 5280953 A monoamine oxidase inhibitor SGTC_943 3253-1379 105 µM -0.395433909545401 0.347552877948933 no 2188 0.346261343872437 3268 668464 SGTC_1781 st038725 66.3 µM -0.396410796260501 0.347188622609826 no 2189 0.345901001407039 3081 4270275 YIL048W NEO1 SGTC_185 k048-0037 25.491 µM -0.399774150180231 0.345935597613826 no 2190 0.344661435890851 3229 6827589 SGTC_2882 9058044 58.44 µM -0.401507731452601 0.34529040532257 no 2191 0.344023173527032 3188 18076804 SGTC_2030 5175110 200 µM -0.402716768434795 0.344840700140358 no 2192 0.343578298357823 3239 2831986 SGTC_616 4092-0450 108 µM -0.4034185872795 0.344579756838669 no 2193 0.343320157605478 3160 787165 SGTC_1350 1495-0454 146 µM -0.403578484752731 0.344520315688247 no 2194 0.343261354848032 3262 1069057 SGTC_1230 0170-0365 3.77 µM -0.403718661049406 0.344468208952594 no 2195 0.343209807731513 3242 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2294 7971431 200 µM -0.406358651035705 0.343487416485705 no 2196 0.342239548319644 3212 5741572 SGTC_955 1216-0110 33 µM -0.406852577451345 0.34330403277784 no 2197 0.342058133914504 3119 3619719 SGTC_3300 9124615 50.48 µM -0.408114310014221 0.342835747567808 no 2198 0.341594877302404 3301 24824903 SGTC_1942 st076330 65.2 µM -0.40826457830592 0.342779992375458 no 2199 0.341539720809934 3256 24208414 SGTC_2085 5307070 144.047 µM -0.409777702893819 0.342218757220459 no 2200 0.340984511989525 3099 2840351 SGTC_11 0438-0307 1.3 µM -0.410829291603562 0.341828916058449 no 2201 0.340598856558493 3225 4011476 SGTC_2082 5219693 150 µM -0.412758843078663 0.341114038463437 no 2202 0.339891654077442 3121 2834649 SGTC_2272 7805186 180 µM -0.412761422439839 0.3411130832194 no 2203 0.339890709088672 3255 2956062 YPR165W RHO1 SGTC_2424 5537928 59.2 µM -0.41661492616616 0.33968711174844 no 2204 0.338480044959993 3134 5382802 SGTC_822 1487-0950 154 µM -0.417918170023908 0.339205369798936 no 2205 0.33800347361794 3292 1958375 SGTC_1640 st009078 66.4 µM -0.419008888775523 0.338802389318614 no 2206 0.337604818081729 3237 690618 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.419582235627863 0.338590632659054 no 2207 0.337395333962814 3245 140250 A respiratory chain inhibitor. SGTC_2815 7968870 71.43 µM -0.420649590940375 0.338196557664649 no 2208 0.33700548790615 3141 2977326 YHR190W ERG9 SGTC_1614 st002383 48.6 µM -0.420776158292572 0.338149839862812 no 2209 0.336959271428217 3221 1947235 SGTC_1439 4092-1168 46 µM -0.421899636831764 0.337735257337353 no 2210 0.336549137565321 3214 2886240 SGTC_2744 captopril 92.04 µM -0.421942356094428 0.337719497090079 no 2211 0.336533546426355 3208 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2899 9053889 58.44 µM -0.423137536120408 0.337278679524891 no 2212 0.336097458662102 3247 6470052 SGTC_975 1335-0046 28.5 µM -0.42472534066969 0.336693395900019 no 2213 0.335518454304961 3166 16486740 SGTC_2803 7707263 71.43 µM -0.425046401364932 0.336575097117758 no 2214 0.335401424616681 3111 2199229 SGTC_749 1000-0129 128 µM -0.426474493607366 0.33604909496873 no 2215 0.334881064994191 3313 708470 SGTC_1025 k007-0731 70 µM -0.426764969219184 0.335942144764315 no 2216 0.334775261992897 3117 6256118 SGTC_1696 st025591 34.7925 µM -0.42855759691236 0.335282411448425 no 2217 0.334122604761202 3156 2787147 SGTC_1504 k297-0033 30 µM -0.429096016390579 0.335084358218445 no 2218 0.333926675594892 3095 4388117 SGTC_3022 9087993 49.47 µM -0.429184131080151 0.335051950309682 no 2219 0.33389461524305 3241 17173644 SGTC_473 2-arachidonoylglycerol 10 µM -0.430923311988102 0.334412544463403 no 2220 0.333262066171426 3110 5282280 An endocannabinoid. SGTC_117 lucigenin 22.078 µM -0.430982559833017 0.334390770575551 no 2221 0.333240525762483 3241 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2697 mebhydrolin 72.4 µM -0.431191042432029 0.334314156577592 no 2222 0.333164733278636 3326 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1003 4049-0218 100 µM -0.431709572175431 0.334123635180312 no 2223 0.332976254736763 3308 295161 SGTC_2398 5228213 48.84 µM -0.432653035580629 0.333777091677927 no 2224 0.332633426801527 3349 80771 YMR134W ERG29 SGTC_1516 st013856 110 µM -0.433025716032268 0.333640241472789 no 2225 0.332498043794049 3244 5281404 A mutagen and neurotoxin. SGTC_3160 9100216 49.47 µM -0.434430067900789 0.333124755093736 no 2226 0.331988083621445 3231 17191039 SGTC_3188 9110789 49.47 µM -0.435042536599232 0.332900038784774 no 2227 0.331765776142385 3322 849217 SGTC_1146 3579-1023 7 µM -0.435922896248352 0.332577137734774 no 2228 0.331446336175644 3280 X1146 SGTC_2331 7980721 200 µM -0.436425314277886 0.332392914928702 no 2229 0.331264087877184 3198 2981221 SGTC_933 2914-0560 114 µM -0.436479452225723 0.33237306645482 no 2230 0.331244452134654 3310 463887 SGTC_575 k072-0246 11.9 µM -0.436496807122991 0.33236670376742 no 2231 0.331238157640843 3231 6796779 SGTC_2220 6782180 200 µM -0.437363038784595 0.332049185585056 no 2232 0.330924042395132 3220 833803 SGTC_1371 2421-0008 32.7 µM -0.437543197728892 0.331983163259549 no 2233 0.330858727616122 3162 2827552 SGTC_330 1488-0319 80.1 µM -0.438017972769644 0.331809198818891 no 2234 0.330686627456239 3229 6846614 SGTC_1919 st067113 52.3 µM -0.438030554044953 0.33180458935068 no 2235 0.330682067384019 3285 1268243 SGTC_1336 1486-0901 104 µM -0.44088403004161 0.330759805232461 no 2236 0.329648477841616 3233 5006114 SGTC_1489 4065-0444 182 µM -0.442903228117497 0.3300212824209 no 2237 0.328917866191776 3289 2877968 SGTC_2151 5563267 85.4165 µM -0.443553561762296 0.329783563319212 no 2238 0.328682693223532 3204 5310824 SGTC_2696 st077691 74.316 µM -0.444392903727651 0.329476856854273 no 2239 0.328379271538493 3316 757133 SGTC_522 1273-0010 11.6 µM -0.446140407862152 0.328838664245323 no 2240 0.327747912937192 3372 5705015 SGTC_1632 st005650 90 µM -0.446996990814767 0.328526020169908 no 2241 0.32743861630088 3259 2759605 SGTC_2036 5160441 105 µM -0.447876996080026 0.328204952161936 no 2242 0.32712098559676 3229 134534 YIL048W NEO1 SGTC_1193 1488-0126 41.5 µM -0.448295732942683 0.328052221459585 no 2243 0.326969889886952 3196 1384710 SGTC_3018 9082602 49.47 µM -0.448532889044418 0.327965733541447 no 2244 0.326884327793703 3305 17332089 SGTC_1807 st050092 58.9 µM -0.448875720008952 0.327840723605354 no 2245 0.326760656004234 3190 5008496 SGTC_3297 9117502 71.43 µM -0.450516559638659 0.327242674883276 no 2246 0.326169008262248 3285 7453720 SGTC_2796 7949634 45.45 µM -0.4505239050449 0.327239998645183 no 2247 0.326166360665493 3175 2971588 SGTC_850 0388-0143 75.9 µM -0.451069829839964 0.327041120322138 no 2248 0.325969610687129 3195 67273 SGTC_2823 7987624 58.44 µM -0.452635263568815 0.326471111236084 no 2249 0.325405700931375 3404 2239440 SGTC_2973 9094665 17.96 µM -0.453476789373511 0.326164860320935 no 2250 0.325102726553622 3369 25237061 YIL048W NEO1 SGTC_2994 9053520 71.4286 µM -0.453912207534097 0.326006447464482 no 2251 0.324946008403539 3308 4647384 SGTC_1652 st011932 78 µM -0.45414002002591 0.325923577745205 no 2252 0.324864025191477 3276 1551076 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.454321192888998 0.3258576799276 no 2253 0.324798832304732 3206 91467 include heat shock SGTC_2325 6158266 200 µM -0.455842529558539 0.325304540513986 no 2254 0.32425160938255 3243 3623240 SGTC_1261 0712-0010 12.7 µM -0.456165095256928 0.325187308953736 no 2255 0.324135631610055 3366 2840123 SGTC_1554 st069299 38.7 µM -0.456281860353539 0.32514487673283 no 2256 0.324093653187783 3287 24207999 SGTC_1691 st019933 84.6 µM -0.456753386733173 0.324973547986484 no 2257 0.323924156677553 3278 6176082 SGTC_2189 6047310 154.431 µM -0.457023063657712 0.324875577716855 no 2258 0.32382723407909 3193 711535 SGTC_1573 oleylamine 1.06 µM -0.45763433443389 0.324653555498455 no 2259 0.323607585980275 3233 5356789 An amine of the fatty acid oleic acid. SGTC_1735 st034310 56.75 µM -0.458522012926041 0.324331249000199 no 2260 0.323288725623688 3349 871153 SGTC_548 1436-0017 110 µM -0.459098357438835 0.324122054943527 no 2261 0.323081768082489 3362 9677137 SGTC_1088 bifonazole 369 nM -0.459613410771286 0.323935154537765 no 2262 0.322896865704843 3274 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1092 toremifene 6.32 µM -0.460734546412235 0.323528474996182 no 2263 0.322494533231093 3246 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2142 5622915 118.518 µM -0.460843368391521 0.323489012238417 no 2264 0.322455492262782 3243 5322196 SGTC_1604 st002052 72.4 µM -0.461662450670332 0.323192047321688 no 2265 0.322161701194428 3340 6254834 YHR062C RPP1 SGTC_2191 5911152 200 µM -0.462179064725447 0.323004802622459 no 2266 0.321976457513581 3258 2875902 SGTC_2916 7875993 68.79 µM -0.463110267508199 0.322667405194611 no 2267 0.321642665374829 3362 1299250 SGTC_1027 k015-0025 8.67 µM -0.46358255258751 0.322496340582739 no 2268 0.321473428510708 3197 3598955 SGTC_2506 ethyl hematommate 54.16 µM -0.464172082025622 0.322282862053251 no 2269 0.321262230733154 3262 3940691 An allergen. SGTC_493 zm226600 134 µM -0.465829467789751 0.321683008927505 no 2270 0.320668785272227 3364 5240098 A potassium channel opener. YCR052W RSC6 SGTC_731 3966-0296 387 µM -0.466453534139951 0.321457262593271 no 2271 0.32044544997934 3213 660956 SGTC_1840 st055363 71 µM -0.466911231041457 0.321291739731011 no 2272 0.320281694814539 3257 676033 SGTC_2650 prasterone 100 µM -0.4677651255867 0.320983029665305 no 2273 0.319976281295204 3279 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1101 ebselen 5.29 µM -0.468248826949935 0.320808211092408 no 2274 0.31980332933099 3365 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1441 4106-0040 13 µM -0.468706193129979 0.320642947079022 no 2275 0.31963982978548 3282 2904180 SGTC_939 1165-0479 45.3 µM -0.468938265518509 0.320559103980404 no 2276 0.319556881805323 3336 1377347 SGTC_871 0574-0004 149 µM -0.469220816910949 0.320457036189606 no 2277 0.31945590366001 3200 9551173 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.469560079000695 0.3203345003817 no 2278 0.319334675947144 3171 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2524 avocatin b 10.57 µM -0.469709148336133 0.320280665217336 no 2279 0.319281415463183 3270 6710748 SGTC_2408 sulbentine 18.36 µM -0.470111546407301 0.320135361352341 no 2280 0.319137662625525 3190 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3197 9113331 49.47 µM -0.471000435828017 0.319814485753134 no 2281 0.318820211836093 3401 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_331 k048-0133 24.5 µM -0.471988471706766 0.319457977966374 no 2282 0.318467508626662 3238 6813582 SGTC_8 0354-0001 70 µM -0.472269758944043 0.319356513064324 no 2283 0.318367126431006 3272 4993152 SGTC_1074 carmofur 3.8 µM -0.472869209820839 0.319140326474259 no 2284 0.318153246555672 3282 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2238 6671620 73.2395 µM -0.473278887724399 0.318992615175597 no 2285 0.318007111214969 3228 729941 SGTC_1243 0416-0003 5.65 µM -0.473804375618636 0.318803190116239 no 2286 0.3178197070166 3227 2141977 SGTC_1931 st074438 57.1 µM -0.475163535755419 0.318313466964576 no 2287 0.317335207643927 3295 2787313 SGTC_209 4077-0173 175.592 µM -0.475279129683437 0.31827183159373 no 2288 0.31729401633697 3272 15993494 SGTC_2695 st077686 51.995 µM -0.475387259762371 0.318232886678586 no 2289 0.317255486783079 3267 2876092 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.47811871483168 0.317249773341665 no 2290 0.316282856280136 3266 2333 A French combination drug. SGTC_610 4215-0184 155 µM -0.478213541039825 0.31721566631163 no 2291 0.316249112845408 3307 5605015 SGTC_862 0452-0056 10.2 µM -0.479318113764533 0.316818488722456 no 2292 0.31585616891398 3315 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_215 1287-0124 461.5 µM -0.479331820820883 0.31681356132187 no 2293 0.315851294031405 3277 5560863 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.479670276786008 0.316691903778065 no 2294 0.315730933119182 3492 5282309 SGTC_2263 7948595 193.29 µM -0.479885939975674 0.316614394272723 no 2295 0.315654249675093 3286 2971371 SGTC_2607 solasodine 47.35 µM -0.480662565993999 0.316335341048936 no 2296 0.315378170224704 3240 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.481103219578221 0.316177054173712 no 2297 0.315221569983197 3360 756377 SGTC_1279 0874-0590 65.2 µM -0.481488399485532 0.316038721547876 no 2298 0.315084711263483 3294 3523074 SGTC_1188 1403-0014 4.57 µM -0.482803565183175 0.315566590132729 no 2299 0.314617609576167 3267 9614867 SGTC_3040 9091894 49.47 µM -0.483584612422847 0.315286344285072 no 2300 0.31434034871011 3236 25236966 SGTC_2711 st079103 59.1 µM -0.485272166653957 0.314681199592177 no 2301 0.313741648192271 3267 54693780 SGTC_1273 0849-0096 14.1 µM -0.486014722871213 0.314415081806679 no 2302 0.313478363677462 3301 5286025 SGTC_2759 disulfiram 3.38 µM -0.486107432352739 0.314381863288931 no 2303 0.313445498800101 3230 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3069 9117009 49.47 µM -0.486576486239556 0.314213820729514 no 2304 0.313279245111191 3246 41904981 SGTC_1420 4'-methoxyflavone 42 µM -0.487138906050478 0.314012379793085 no 2305 0.313079948382289 3341 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_539 4859-0462 2.54 µM -0.487289697904739 0.313958380350549 no 2306 0.313026523691399 3356 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_50 0929-0078 56.389 µM -0.488497096419143 0.313526147631249 no 2307 0.312598890938629 3220 1377751 SGTC_25 0118-0223 35.662 µM -0.488797151583177 0.313418771525547 no 2308 0.312492657407366 3394 5333628 SGTC_3032 9089427 49.47 µM -0.489184854739334 0.313280053601945 no 2309 0.312355415468314 3326 17173707 SGTC_2206 7254556 146.969 µM -0.489410616073941 0.313199289683342 no 2310 0.312275510843953 3284 4398905 SGTC_2075 5212009 200 µM -0.490681697778123 0.312744739903538 no 2311 0.311825796607838 3351 780898 SGTC_3142 9086498 49.47 µM -0.49070893885298 0.312735001373044 no 2312 0.311816161664141 3301 25236367 SGTC_3207 9114163 49.47 µM -0.491752766234163 0.312361937496785 no 2313 0.311447065592027 3469 849233 SGTC_2070 5230947 200 µM -0.492163634605947 0.312215145862385 no 2314 0.311301834977229 3390 2835538 SGTC_2595 hexamethylquercetagetin 100 µM -0.492302552840052 0.312165521052321 no 2315 0.311252737862343 3258 386331 SGTC_2737 bleomycin 30.5 nM -0.492658768355523 0.31203828819628 no 2316 0.311126857897806 3352 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_110 0850-0284 111.64 µM -0.494306539321232 0.311450030215137 no 2317 0.31054485377004 3215 3906265 SGTC_2134 5324836 1.464 µM -0.49464767859745 0.311328302772686 no 2318 0.310424420179394 3235 699272 SGTC_368 fentichlor 4.58 µM -0.495066699574782 0.311178813324571 no 2319 0.310276519549832 3302 7329 A pesticide. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.496421061937453 0.310695845632374 no 2320 0.309798684087106 3297 688761 SGTC_601 0986-0029 62.9 µM -0.496511364571016 0.310663655160198 no 2321 0.309766835636294 3324 24747981 SGTC_647 0140-0236 81 µM -0.498178647184813 0.310069574178625 no 2322 0.309179065612771 3308 990837 SGTC_1759 st043059 70 µM -0.498676572424251 0.309892251004295 no 2323 0.309003625742955 3246 669426 SGTC_69 0096-0274 206.684 µM -0.500716025169907 0.30916641456009 no 2324 0.308285496231995 3523 6741392 SGTC_1998 st075797 76.8 µM -0.501634871213956 0.308839642417173 no 2325 0.307962192700379 3392 24208315 SGTC_2519 cryptotanshinone 88.04 µM -0.503071391111489 0.308329071434343 no 2326 0.307457039981067 3401 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_765 1319-0117 244 µM -0.503546070810191 0.308160441158771 no 2327 0.307290198878387 3325 3487746 YGL099W LSG1 SGTC_891 0929-0073 133 µM -0.50378454542375 0.308075738171576 no 2328 0.307206394524964 3382 5603632 SGTC_1505 k297-0037 20.6 µM -0.504621366895563 0.307778591287674 no 2329 0.306912399781752 3265 4089396 SGTC_1704 st028805 70.8 µM -0.50475623113954 0.307730714139142 no 2330 0.306865030462469 3344 2876101 SGTC_1799 st045822 46.1415 µM -0.505682836429593 0.307401855466449 no 2331 0.306539659571849 3384 3674992 SGTC_2469 5655019 90.81 µM -0.50710528789773 0.306897318746952 no 2332 0.306040472469977 3402 2788239 SGTC_555 4296-0685 37 µM -0.507345398393079 0.306812188737526 no 2333 0.305956244933416 3346 2908540 YHR072W ERG7 SGTC_2774 tamoxifen 10.92 µM -0.508010641633846 0.306576384405252 no 2334 0.305722940141981 3388 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_872 0588-0139 234 µM -0.508106650889865 0.306542359252921 no 2335 0.305689275628296 3326 2047100 SGTC_1298 1079-1278 263 µM -0.510180753483531 0.305807716218962 no 2336 0.304962417338858 3371 2840950 SGTC_2748 diazoxide 86.69 µM -0.510515783857837 0.305689122290719 no 2337 0.304845079770182 3327 3019 A potassium channel activatior. SGTC_2307 7538926 6.34 µM -0.511021379068722 0.305510190467983 no 2338 0.304668043335392 3297 96582 SGTC_1922 5578187 25 µM -0.511410132124425 0.305372641053505 no 2339 0.304531950806819 3463 1350412 SGTC_1406 3909-7906 11.9 µM -0.511586376644299 0.305310290901001 no 2340 0.304470261008002 3370 X1406 SGTC_2870 9038528 12.99 µM -0.511886410602826 0.305204160661111 no 2341 0.304365254738378 3398 6463316 SGTC_2001 4023502 57.655 µM -0.512025635231739 0.305154918653542 no 2342 0.304316534201373 3353 108941 YCR052W RSC6 SGTC_2176 5809774 33.9695 µM -0.512531489059769 0.304976034181883 no 2343 0.304139543969046 3355 2870539 SGTC_54 0159-0055 9 µM -0.512755015945896 0.30489700348321 no 2344 0.304061350070893 3492 3319099 SGTC_2158 5657123 3.6195 µM -0.5132321248255 0.304728346177853 no 2345 0.303894478416204 3355 2858827 SGTC_1285 0929-0069 65.5 µM -0.513659257197772 0.304577390694846 no 2346 0.303745121001056 3312 1206237 SGTC_1539 benzyladenosine 56 µM -0.514672143064495 0.304219553510019 no 2347 0.303391071378129 3302 92208 A nucleotide analog. SGTC_2512 diallyl trisulfide 49.23 µM -0.516162862509348 0.303693245911137 no 2348 0.302870332913203 3390 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_10 0279-0212 42.575 µM -0.516826408022031 0.303459107896035 no 2349 0.302638671809113 3357 39851 YBR002C RER2 SGTC_2472 5377652 49.4 µM -0.517417904899387 0.303250460897909 no 2350 0.302432231729697 3353 1610903 SGTC_1602 st001878 87.6 µM -0.518674744873537 0.302807331159247 no 2351 0.301993788072365 3434 595405 YLR310C CDC25 SGTC_1115 galangin 695.678 nM -0.518867683904899 0.30273933145563 no 2352 0.301926507338815 3455 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1878 temozolomide 1 mM -0.520962364975675 0.302001519794718 no 2353 0.301196494512472 3422 5394 DNA alkylating agent. SGTC_1118 chelidonine 707.474 nM -0.521075910157898 0.301961548743914 no 2354 0.3011569458516 3412 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1898 st060199 18.6 µM -0.521512407775866 0.301807911618967 no 2355 0.301004932162133 3366 688866 SGTC_3122 9126309 49.47 µM -0.522136417062259 0.301588335737825 no 2356 0.300787676169765 3421 17591206 SGTC_3277 9138724 49.47 µM -0.522316473544547 0.301524990970709 no 2357 0.300725000594165 3301 15943418 SGTC_2384 9036245 200 µM -0.52324176324427 0.301199563916217 no 2358 0.300403010972257 3321 6462766 SGTC_1806 st050005 60.3 µM -0.524058944670259 0.300912290494965 no 2359 0.300118771318424 3328 5194765 SGTC_1980 st071811 45.7 µM -0.524236489493494 0.300849892412302 no 2360 0.30005703211274 3460 4974850 SGTC_1229 0139-0193 12.2 µM -0.524476796855722 0.300765445748387 no 2361 0.299973477095804 3442 3090752 SGTC_1835 st008666 49.2 µM -0.524705125036724 0.300685218611336 no 2362 0.299894097003398 3281 690455 SGTC_1755 st041960 45.185 µM -0.524745553152992 0.300671014485551 no 2363 0.299880042840885 3410 2257073 SGTC_1779 st039427 55 µM -0.524793269834509 0.300654249964855 no 2364 0.299863455313457 3468 1124498 SGTC_2827 7993847 71.43 µM -0.525944149058975 0.30025003416673 no 2365 0.299463506425569 3397 2985692 SGTC_535 2293-4129 48.2 µM -0.5267993553824 0.299949824831198 no 2366 0.299166465303379 3442 396118 YIL048W NEO1 SGTC_3068 9116768 49.47 µM -0.527092119036544 0.299847085082837 no 2367 0.299064809645228 3400 41904888 SGTC_462 ag-879 158 µM -0.527355633456114 0.299754623414247 no 2368 0.298973323545375 3412 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_61 0978-8327 98.565 µM -0.528760389576761 0.2992619420699 no 2369 0.298485839402327 3432 6150059 YHR072W ERG7 SGTC_1242 0402-0103 60.1 µM -0.529810986027085 0.298893713240663 no 2370 0.298121493719951 3352 432868 SGTC_2710 st078562 53.7235 µM -0.530428994588322 0.298677200514844 no 2371 0.297907263728615 3347 17250908 SGTC_534 k292-0788 63.4 µM -0.530941739825377 0.298497619816972 no 2372 0.297729576104603 3463 4146317 SGTC_1981 st071826 47 µM -0.531827850565171 0.298187389769509 no 2373 0.297422615788934 3373 11838600 SGTC_928 2764-0428 58.7 µM -0.533290465774174 0.297675645277503 no 2374 0.296916263259164 3409 662578 SGTC_1408 3909-7976 48.8 µM -0.534739682463125 0.297168984329948 no 2375 0.296414938642119 3394 24152374 SGTC_2048 5246248 200 µM -0.536143886044434 0.296678436809959 no 2376 0.295929555758116 3450 677046 SGTC_2383 9036125 200 µM -0.537485399552929 0.296210136241414 no 2377 0.295466183764903 3348 79580 SGTC_3248 9135562 49.47 µM -0.538395084659049 0.295892773005602 no 2378 0.295152159552453 3397 17650701 SGTC_2357 9067248 200 µM -0.538545980936034 0.295840144693429 no 2379 0.295100084869327 3419 9150235 SGTC_57 miconazole 162.5 nM -0.538629061193524 0.295811170507602 no 2380 0.295071415470642 3380 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1497 4476-2978 41.3 µM -0.538633700969046 0.295809552427337 no 2381 0.295069814411186 3424 1528379 SGTC_1838 st055369 84.5 µM -0.538743487968861 0.295771266378271 no 2382 0.295031931091976 3387 676036 SGTC_2074 5212007 75.395 µM -0.540898754179531 0.295020121325591 no 2383 0.294288684828334 3411 758611 SGTC_1199 1638-0010 4.46 µM -0.541854902812501 0.294687169737194 no 2384 0.293959232923423 3318 3111136 SGTC_153 4077-0274 519.67 µM -0.543387247360951 0.29415393603521 no 2385 0.293431602117306 3563 3121976 SGTC_1220 1838-0075 193 µM -0.545879323960298 0.293287682981052 no 2386 0.29257444589271 3407 5529645 SGTC_1198 1612-1005 86.7 µM -0.545938885389818 0.293266993730297 no 2387 0.29255397382717 3520 6998509 SGTC_2858 9025781 8.96 µM -0.545976463389108 0.293253940989193 no 2388 0.292541058105163 3473 4894980 YPL153C RAD53 SGTC_1342 1486-1464 234 µM -0.546921873576112 0.292925640832706 no 2389 0.292216203735863 3421 3253938 SGTC_2875 9039966 71.43 µM -0.548377839860669 0.292420380458489 no 2390 0.291716244636173 3392 6463691 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.549257600253734 0.292115275897328 no 2391 0.291414340182387 3499 5393153 SGTC_1232 0279-0259 161 µM -0.549354428898918 0.292081704373204 no 2392 0.291381120724356 3393 1560000 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.549771357813425 0.291937171189267 no 2393 0.291238103150998 3423 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2025 5147754 141 µM -0.551143702745938 0.291461667498721 no 2394 0.290767584381448 3419 315777 YLR208W SEC13 SGTC_2328 6201408 200 µM -0.551647081404478 0.291287342471871 no 2395 0.290595086370199 3435 2890418 SGTC_1013 4112-3890 241 µM -0.551901810187586 0.291199145913447 no 2396 0.290507814051604 3293 705171 SGTC_1455 4262-0120 131 µM -0.554277224640842 0.29037729015229 no 2397 0.289694567354208 3527 1529587 SGTC_2985 9022375 71.43 µM -0.554472628247383 0.290309731972839 no 2398 0.289627716580129 3525 4939335 SGTC_847 0342-0274 5.54 µM -0.555191615920219 0.290061215010424 no 2399 0.289381801487918 3449 18097 SGTC_2232 chlorophetanol 41.5365 µM -0.555815175691841 0.289845763329359 no 2400 0.289168605031887 3474 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1063 disulfiram 1.84 µM -0.556366090337367 0.28965547439357 no 2401 0.28898030757106 3425 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3027 9089541 49.47 µM -0.557052328427725 0.289418526046061 no 2402 0.288745838539086 3464 9943819 SGTC_1563 conessine 56.1 µM -0.557678403105764 0.289202430741248 no 2403 0.288532003892246 3492 441082 An anti-amoebic, histamine inhibitor. SGTC_128 0906-2981 13.371 µM -0.557822844531477 0.289152586255051 no 2404 0.288482680786187 3454 6740226 SGTC_2171 5739187 198.077 µM -0.557955819699913 0.289106702167039 no 2405 0.288437276631211 3325 2262761 SGTC_2425 5628681 7.85 µM -0.558374135456575 0.288962381483029 no 2406 0.288294465365726 3441 5714958 SGTC_1486 3970-0793 4.53 µM -0.559292034479424 0.288645821334605 no 2407 0.287981215356916 3467 2844330 SGTC_2787 5284540 71.43 µM -0.561008541755233 0.288054280147186 no 2408 0.28739585710189 3396 736958 SGTC_898 1000-0849 28.3 µM -0.561379075471454 0.287926662276791 no 2409 0.287269572682478 3434 6751807 SGTC_2317 5986382 200 µM -0.562977072178583 0.287376592138768 no 2410 0.286725248296779 3489 877883 SGTC_3287 9117173 37.0625 µM -0.563055835081622 0.287349492852242 no 2411 0.286698431999356 3388 2789709 SGTC_2741 miltefosine 3.04 µM -0.563600642520409 0.28716207867146 no 2412 0.286512974727532 3365 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_7 0192-1582 4.227 µM -0.563946021365972 0.287043298058708 no 2413 0.286395434199194 3478 252616 SGTC_797 k781-0471 270 µM -0.564418767298602 0.286880751856315 no 2414 0.286234584774459 3379 23738129 SGTC_130 0136-0219 337.655 µM -0.564583380095817 0.286824162592479 no 2415 0.286178586170143 3433 234244 SGTC_2714 st079313 56.9 µM -0.564647938994814 0.286801970497645 no 2416 0.286156625700229 3443 2939799 SGTC_2666 tannic acid 100 µM -0.565548281421272 0.28649256301096 no 2417 0.285850447075823 3481 16134267 A thiamine antagonist. SGTC_1000 4048-0884 8.67 µM -0.565549548095344 0.286492127823233 no 2418 0.285850016428887 3474 13040088 SGTC_691 1548-0686 185 µM -0.565779201971402 0.286413231456759 no 2419 0.285771943243463 3403 46495133 SGTC_1040 k898-0338 155 µM -0.566873934587942 0.28603728369908 no 2420 0.285399917160045 3527 20969351 SGTC_2740 felodipine 17.08 µM -0.568570470457781 0.285455131320355 no 2421 0.284823834669415 3424 3333 L-type calcium channel blocker SGTC_2938 9059746 27.26 µM -0.568827480853224 0.285366989537346 no 2422 0.284736611610265 3438 6471769 SGTC_3143 9086658 49.47 µM -0.570710690200111 0.284721538183009 no 2423 0.284097885550255 3464 25236626 SGTC_250 brefeldin a 552.239 µM -0.571634016799954 0.28440533191501 no 2424 0.283784972445295 3400 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_159 3970-0959 50 µM -0.572466914496983 0.284120238332125 no 2425 0.283502847116191 3571 6615653 SGTC_1774 st048371 48.465 µM -0.572962559056834 0.283950648437107 no 2426 0.283335022508588 3389 4242727 SGTC_1803 st050068 52.4 µM -0.57320974113097 0.283866090649255 no 2427 0.283251344784287 3545 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1465 k213-0056 144 µM -0.573408979645226 0.283797942506942 no 2428 0.283183905862525 3383 24048857 YMR208W ERG12 SGTC_2377 9073351 62.6 µM -0.575328161467769 0.28314190121778 no 2429 0.282534689540781 3399 7337946 YHR072W ERG7 SGTC_2514 salinomycin 42.74 µM -0.575973472012578 0.282921475823533 no 2430 0.282316556274433 3512 23682228 A polyether potassium ionophore. SGTC_2166 5933061 31.504 µM -0.577458994951145 0.282414363794514 no 2431 0.281814715576328 3734 2877375 SGTC_1661 st013063 9.66 µM -0.578169181938871 0.282172082271192 no 2432 0.281574951556061 3485 721395 SGTC_1953 st076800 12.1 µM -0.578662087069649 0.282003985670136 no 2433 0.281408601247065 3412 297591 SGTC_2072 5231554 129 µM -0.580660187467832 0.281323063242944 no 2434 0.280734749554094 3554 789545 SGTC_172 1112-0046 2.638 µM -0.581456092174102 0.281052052146983 no 2435 0.280466551254349 3382 2802135 YIL048W NEO1 SGTC_366 0181-0206 4.31 µM -0.583439633925056 0.280377191783519 no 2436 0.27979869170848 3553 274874 SGTC_1793 st048256 72.231 µM -0.583830242277604 0.280244387642736 no 2437 0.279667264651989 3459 672022 SGTC_1166 k206-0078 225 µM -0.583912944073172 0.280216273513031 no 2438 0.279639442020786 3491 5404595 SGTC_622 1348-1566 26.3 µM -0.585381820316151 0.279717162957433 no 2439 0.279145504983718 3480 7340407 SGTC_417 st075190 100 µM -0.585420047419305 0.279704179503067 no 2440 0.279132656072075 3540 222757 SGTC_799 1310-0557 151 µM -0.586501236000587 0.279337085739971 no 2441 0.278769365586065 3532 5354492 SGTC_141 0443-0274 32.331 µM -0.588245915652762 0.278745212275292 no 2442 0.278183621042351 3597 1627241 SGTC_2895 9054447 58.44 µM -0.588253250931744 0.278742725109457 no 2443 0.278181159623073 3478 2697450 SGTC_1718 roemerine 11.9335 µM -0.588858530045902 0.278537530947288 no 2444 0.277978089341034 3492 235224 An aporphine alkaloid with mutagenic activity. SGTC_47 0149-0135 24.25 µM -0.588909197124824 0.27852035776522 no 2445 0.277961093889812 3410 5239155 SGTC_2526 patulin 37.61 µM -0.589231524871982 0.278411119554127 no 2446 0.277852986141961 3530 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_559 1550-0661 158 µM -0.590545452673514 0.277966040112097 no 2447 0.277412511244506 3499 5830875 SGTC_2354 9060492 162 µM -0.590677258424996 0.277921411448357 no 2448 0.277368344159049 3517 6471895 SGTC_2449 5812982 45.77 µM -0.590734702285665 0.277901962384254 no 2449 0.277349096242498 3495 776185 SGTC_1590 st077108 57.8 µM -0.591437703451496 0.277663997483725 no 2450 0.277113592088123 3496 5489485 SGTC_1834 st055981 52.8 µM -0.591651690434873 0.277591582957667 no 2451 0.27704192625639 3553 471719 YDL150W RPC53 SGTC_641 4092-0595 30 µM -0.592934621124166 0.27715762483394 no 2452 0.276612453558648 3523 786260 SGTC_2488 5268135 45.7 µM -0.593110741564842 0.277098077080123 no 2453 0.276553521124799 3486 1270356 YLR208W SEC13 SGTC_186 3455-3465 67.277 µM -0.596246673089162 0.27603884260436 no 2454 0.275505225022486 3478 755278 SGTC_1257 0669-0121 16 µM -0.596336930869721 0.276008385380385 no 2455 0.275475082125244 3524 4307855 SGTC_3181 9108277 49.47 µM -0.596435976356585 0.27597496466986 no 2456 0.2754420063128 3441 17097298 SGTC_1706 st031321 9.9705 µM -0.596736278194187 0.275873646601651 no 2457 0.27534173375514 3515 6103185 SGTC_1830 st055982 50.3 µM -0.59683814444582 0.275839282359059 no 2458 0.275307724092721 3499 455313 An antimicrobial agent. SGTC_2387 9077560 195.08 µM -0.597636478617902 0.275570039824888 no 2459 0.275041259195184 3423 5303272 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.599276543065323 0.275017324973987 no 2460 0.274494243708297 3575 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1954 st077032 68.9 µM -0.600043919531654 0.274758900634305 no 2461 0.274238482874412 3463 698907 SGTC_1952 st077036 64.1 µM -0.600053504217192 0.274755673619794 no 2462 0.274235289114729 3541 2937007 SGTC_2283 7944793 200 µM -0.600702244155334 0.274537296421513 no 2463 0.274019162031183 3491 2970533 SGTC_182 3448-4371 550.524 µM -0.600945351678659 0.274455484244902 no 2464 0.273938192682199 3539 3491403 SGTC_1616 st002734 56.1 µM -0.601393773648819 0.27430460984283 no 2465 0.273788872372711 3463 4026101 SGTC_1741 st038134 10.228 µM -0.601828572852504 0.274158358020102 no 2466 0.273644126763315 3599 1272587 SGTC_1067 clotrimazole 1.36 µM -0.601879420869124 0.274141256974155 no 2467 0.273627201820041 3497 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3351 9150312 21.596 µM -0.602044532406248 0.274085730812141 no 2468 0.273572247429214 3497 4904905 SGTC_722 3534-0461 190 µM -0.602230103453258 0.274023330854918 no 2469 0.273510489980046 3497 658262 SGTC_19 0279-0214 38.434 µM -0.602433078619273 0.273955086643829 no 2470 0.273442948398605 3554 3566274 YBR002C RER2 SGTC_2106 5357045 167.29 µM -0.602766170150132 0.273843112980047 no 2471 0.273332127471434 3500 668842 SGTC_1841 st054148 70 µM -0.603209533097521 0.273694105058272 no 2472 0.273184653305251 3468 675442 SGTC_500 h-89 112 µM -0.60435679833513 0.27330871195911 no 2473 0.272803225836513 3571 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2964 9083345 53.42 µM -0.611954748975039 0.27076318814443 no 2474 0.270283848488599 3466 17741579 SGTC_3109 9122853 49.47 µM -0.612507406896053 0.27057849525023 no 2475 0.270101049480129 3532 1234709 SGTC_1920 st075728 45.7 µM -0.614879266147382 0.269786558284374 no 2476 0.269317228238808 3567 3400306 SGTC_1591 genipin 88.4 µM -0.615331079718388 0.269635834555373 no 2477 0.269168048196244 3547 442424 A DNA cross-linking agent. SGTC_1768 st044301 37.178 µM -0.615479420030591 0.269586357847356 no 2478 0.269119078155566 3495 3931349 SGTC_817 1391-0715 46 µM -0.619051855972866 0.268396200527532 no 2479 0.267941098984351 3478 1353946 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.624548249852844 0.266570251162603 no 2480 0.266133796739741 3535 6708784 An antioxidant flavonoid SGTC_2638 epoxomicin 18 µM -0.625046896387553 0.266404907827565 no 2481 0.265970139710279 3533 9915668 A protesome inhibitor. SGTC_662 k832-1615 104 µM -0.625106927892195 0.266385005826301 no 2482 0.26595044066059 3533 5878478 SGTC_734 2023-0417 80 µM -0.626734231869045 0.265845799086123 no 2483 0.265416730438705 3534 3935732 SGTC_107 0358-0022 2.6945 µM -0.626923685641912 0.265783059595278 no 2484 0.265354630236427 3520 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1937 st074714 47.2 µM -0.628305845760438 0.265325570825683 no 2485 0.264901801436426 3479 17250970 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.629022921987436 0.265088379407295 no 2486 0.264667024900963 3498 279621 SGTC_1150 3909-7983 10.9 µM -0.629263338712953 0.265008879503546 no 2487 0.26458833422285 3526 23965914 SGTC_3221 9128209 49.47 µM -0.629470373791687 0.26494042779887 no 2488 0.264520579214078 3557 16460723 SGTC_1020 4335-0961 93.3 µM -0.629909607068246 0.264795234502389 no 2489 0.264376863466503 3487 669075 SGTC_2150 5556613 200 µM -0.630317130968143 0.26466055926968 no 2490 0.26424355848265 3554 743190 SGTC_882 0843-0131 351 µM -0.631773332880797 0.264179610151751 no 2491 0.26376750068682 3585 5425421 SGTC_3212 9128307 49.47 µM -0.632672025782628 0.263883015399005 no 2492 0.263473920719024 3435 27243542 SGTC_1445 4239-0156 97.7 µM -0.63358895408367 0.263580577488829 no 2493 0.263174555703138 3623 4008346 SGTC_1364 1653-0028 37.6 µM -0.634503160589912 0.263279213509613 no 2494 0.262876252411146 3535 5718652 SGTC_1315 1237-0019 3.69 µM -0.635188824199507 0.263053303188006 no 2495 0.262652635609384 3568 825140 SGTC_458 nppb 133 µM -0.637519672029099 0.262286084147316 no 2496 0.261893200163194 3626 4549 A chloride channel blocker. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.637830379932218 0.262183898557512 no 2497 0.261792050625045 3549 688662 SGTC_618 k072-0232 33.2 µM -0.638619967024318 0.261924311034645 no 2498 0.26153509435731 3544 5872756 YGL099W LSG1 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.639416653135813 0.261662523250531 no 2499 0.261275959136239 3561 97141 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.640016517176228 0.261465499039181 no 2500 0.261080930610539 3589 688798 SGTC_3305 9127027 53.8275 µM -0.6401465673683 0.261422794348852 no 2501 0.261038658406937 3524 41905295 SGTC_3272 9137413 49.47 µM -0.641690223162992 0.260916176524696 no 2502 0.260537169248734 3542 17614870 SGTC_338 4055-0136 114 µM -0.64199204854433 0.260817178439811 no 2503 0.260439172913207 3547 2900563 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.642934454142759 0.260508195813075 no 2504 0.260133315909713 3555 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1017 4239-0030 168 µM -0.644062693413934 0.260138532720926 no 2505 0.259767390410766 3534 1149593 SGTC_959 1222-0044 107 µM -0.645311947541099 0.259729535276793 no 2506 0.259362525882866 3574 6083612 SGTC_2999 9069765 71.4286 µM -0.645877279472982 0.2595445585164 no 2507 0.259179417486888 3584 2097066 SGTC_1839 st053978 48 µM -0.64590674429851 0.259534919483024 no 2508 0.2591698757988 3629 3788398 SGTC_1133 3473-0247 50 µM -0.648821591757723 0.258582279646205 no 2509 0.258226849806251 3543 711311 SGTC_2370 9071495 200 µM -0.649116646680074 0.258485949864627 no 2510 0.258131491396937 3540 21791103 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.649449447347978 0.258377319130816 no 2511 0.258023955905883 3604 229346 A bile salt which induces apoptosis. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.65018124578425 0.258138533235306 no 2512 0.257787576875568 3576 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_373 0844-0104 25.9 µM -0.651727363805882 0.257634411290302 no 2513 0.257288533397596 3603 5375804 SGTC_3151 9099821 49.47 µM -0.654188420271199 0.256833023408252 no 2514 0.256495210509361 3574 17174189 SGTC_737 1950-0117 57.9 µM -0.655133603216268 0.256525590935888 no 2515 0.256190869313513 3587 5393513 SGTC_1772 st048439 82.2 µM -0.655594804317302 0.256375649179166 no 2516 0.256042434704537 3575 2927068 YDL195W SEC31 SGTC_540 1187-0821 17.3 µM -0.658536413003828 0.2554203742879 no 2517 0.255096753482337 3608 847520 SGTC_2683 piperine 63.03 µM -0.658670176803792 0.255376979320282 no 2518 0.255053793979643 3567 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_567 1080-0542 68.4 µM -0.659400631433694 0.255140076955642 no 2519 0.254819268381311 3563 5950415 SGTC_1292 0kpi-0043 232 µM -0.660966084849633 0.254632753644598 no 2520 0.254317031863545 3590 3333905 SGTC_1530 rhein 70.4 µM -0.661014758837715 0.254616988126549 no 2521 0.254301424355871 3642 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_380 3970-0968 6 µM -0.661764397244446 0.254374244628344 no 2522 0.254061113256201 3578 2891601 SGTC_606 k015-0008 38.6 µM -0.661935911511996 0.254318722943139 no 2523 0.254006147789573 3661 1970475 SGTC_3223 9129970 49.47 µM -0.662239297305935 0.254220528069043 no 2524 0.253908936513898 3657 17248386 SGTC_2083 5306046 65.942 µM -0.663661849805178 0.253760365197153 no 2525 0.253453380919925 3641 539837 SGTC_390 dec-rvkr-cmk 16.7 µM -0.666430473307991 0.252866034855489 no 2526 0.252567994984261 3665 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2396 5342950 42.78 µM -0.666526367865342 0.25283508841867 no 2527 0.25253735781508 3619 1886677 SGTC_1550 gossypolone 36.6 µM -0.667315766305917 0.252580414921603 no 2528 0.252285228834243 3633 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1750 st081859 2.357 µM -0.667599800468279 0.252488813692779 no 2529 0.252194542557707 3638 5291695 SGTC_1426 4048-4480 71.7 µM -0.667992834661142 0.252362088749438 no 2530 0.252069083168382 3610 14224343 SGTC_868 0527-0199 213 µM -0.668120967661926 0.252320782423288 no 2531 0.252028189295362 3568 2849450 SGTC_2995 9067767 71.4286 µM -0.668182776811083 0.252300858238582 no 2532 0.252008464048089 3604 11673567 SGTC_1398 3558-0053 112 µM -0.669138334564346 0.251992939678098 no 2533 0.251703619130241 3544 4532369 SGTC_2028 5153890 36.43 µM -0.670047681276319 0.251700096396199 no 2534 0.251413697544498 3610 2830968 YPR165W RHO1 SGTC_383 2324-0395 7.37 µM -0.671034714507875 0.251382438709121 no 2535 0.251099207505373 3634 3146421 SGTC_1722 st034304 3.6505 µM -0.671670218669827 0.251178026099093 no 2536 0.250896832380292 3645 4036148 YLR033W RSC58 SGTC_786 4544-0069 423 µM -0.671983205106797 0.25107738500307 no 2537 0.25079719416722 3639 748821 YLR208W SEC13 SGTC_707 0865-0008 204 µM -0.672214198959624 0.25100312238747 no 2538 0.250723671465023 3640 723043 SGTC_656 4090-1979 187 µM -0.672953949005138 0.25076537709122 no 2539 0.250488294310896 3647 22330961 SGTC_191 3914-0123 66.505 µM -0.673209703888329 0.250683208803245 no 2540 0.250406944265555 3552 3144412 SGTC_435 c-PAF 6.7 µM -0.674371146236605 0.250310243002038 no 2541 0.25003769106723 3605 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.674490759476595 0.250271849160726 no 2542 0.249999679274407 3616 6708760 SGTC_1966 st070145 16.1 µM -0.674527981567813 0.250259902131603 no 2543 0.249987851122365 3590 3748532 SGTC_1335 1486-0900 202 µM -0.674832622311775 0.250162134149551 no 2544 0.249891055874239 3651 X1335 SGTC_1066 ketoconazole 628 nM -0.675503838442796 0.249946793085707 no 2545 0.249677856752065 3656 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_798 1287-0182 476 µM -0.67591753247073 0.249814119858026 no 2546 0.24954650279585 3670 1649755 SGTC_2128 5255449 168.493 µM -0.677737719167986 0.249230823576625 no 2547 0.24896900309166 3650 736008 SGTC_1896 st058441 89 µM -0.678032565592306 0.249136405420148 no 2548 0.248875522675926 3605 688759 SGTC_2210 7115885 190.385 µM -0.680137309303701 0.248462960040741 no 2549 0.248208761331387 3659 2927039 SGTC_3320 9137005 35.139 µM -0.680388745146385 0.248382574161695 no 2550 0.248129172766081 3629 4908713 SGTC_906 1165-0455 526 µM -0.682348621325513 0.247756462847931 no 2551 0.247509267719199 3633 3252859 SGTC_1197 1601-0112 267 µM -0.683603578530441 0.247355991287412 no 2552 0.247112762181841 3651 7350313 SGTC_1663 st014140 55.4 µM -0.683937792417937 0.247249398091074 no 2553 0.247007224141603 3712 4207120 SGTC_1362 1611-0397 101 µM -0.686458900455916 0.246446115324086 no 2554 0.246211886508042 3647 27816 SGTC_3340 9146634 11.102 µM -0.686577565160906 0.246408340523292 no 2555 0.24617448504825 3664 4907387 SGTC_2305 7443522 69.23 µM -0.688728425281308 0.245724190585524 no 2556 0.245497092363449 3620 5415886 SGTC_1734 st037168 69.4 µM -0.689531406467242 0.245469038410479 no 2557 0.245244458132252 3664 708907 SGTC_339 3091-4833 71.4 µM -0.689991768380393 0.245322819829098 no 2558 0.245099681963453 3626 3240077 SGTC_1418 3966-3099 2.4 µM -0.69080474326439 0.24506471989876 no 2559 0.244844127182726 3657 740335 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.69219640604635 0.244623239743101 no 2560 0.244406997695993 3620 641818 YHR062C RPP1 SGTC_2237 6667747 47.222 µM -0.69230254661841 0.244589586130954 no 2561 0.244373675585185 3606 729940 YDL015C TSC13 SGTC_127 0180-0333 59.125 µM -0.692686217281893 0.244467957844546 no 2562 0.244253245212426 3638 771601 SGTC_2680 butyl paraben 22.24 µM -0.694263272392751 0.243968354551036 no 2563 0.243758559649094 3696 7184 An antifungal and steroid mimetic. SGTC_489 paxilline 115 µM -0.694696725063387 0.243831135446389 no 2564 0.243622690424524 3649 105008 A toxic potassium channel blocker. SGTC_2623 humulene 100 µM -0.695729343341754 0.243504404996906 no 2565 0.243299172753815 3615 6187145 An anti-inflammatory. SGTC_2640 pentamidine 10.38 µM -0.695975739573978 0.243426477799762 no 2566 0.243222011531748 3686 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1973 st070275 50.2 µM -0.696173840099173 0.243363834752906 no 2567 0.243159984144687 3599 17118334 SGTC_1851 st056236 18.9 µM -0.696222922257568 0.243348315414065 no 2568 0.243144617319614 3675 5393171 SGTC_3155 9099265 49.47 µM -0.697296908424637 0.243008864533398 no 2569 0.242808501215775 3624 25236499 SGTC_515 4092-1064 102 µM -0.69928079259151 0.242382499626046 no 2570 0.242188284086088 3703 717353 SGTC_2320 7373003 200 µM -0.700621975007924 0.241959548809397 no 2571 0.241769480365496 3688 5415828 SGTC_3148 9097893 49.47 µM -0.701467982896974 0.241692960631489 no 2572 0.241505504387899 3636 17174100 SGTC_2181 6316240 54.2555 µM -0.702597563729812 0.241337263602611 no 2573 0.24115329060433 3669 12779990 SGTC_712 r015-0009 80.6 µM -0.704757442424348 0.240657925654387 no 2574 0.240480598522884 3678 6813872 YLR060W FRS1 SGTC_1123 mangostin 811.285 nM -0.704854861185433 0.240627309475903 no 2575 0.240450281649895 3666 5281650 An antioxidant. SGTC_984 1492-0255 2.91 µM -0.70561803285993 0.240387537884719 no 2576 0.240212853455871 3632 1585198 SGTC_2757 clomiphene 4.22 µM -0.705625356000501 0.240385237747156 no 2577 0.240210575793241 3730 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1932 st074806 40.9 µM -0.706221231828886 0.240198118285355 no 2578 0.240025284357358 3778 17251235 SGTC_2260 7964312 200 µM -0.706502199311262 0.240109915228834 no 2579 0.239937942748362 3708 231951 SGTC_2364 9055074 200 µM -0.707043737290236 0.239939962085456 no 2580 0.239769649051801 3690 6470630 SGTC_3015 9080845 49.47 µM -0.707328123350024 0.239850738290355 no 2581 0.239681296226602 3733 5296973 SGTC_558 k064-0027 21.3 µM -0.708849839871832 0.239373619872248 no 2582 0.239208832637869 3718 5088526 SGTC_823 0417-1665 178 µM -0.709908171469874 0.239042096865234 no 2583 0.238880541398348 3720 3429856 SGTC_3130 9127414 49.47 µM -0.710870669667043 0.238740811796963 no 2584 0.238582191463279 3700 1494646 SGTC_2019 4016004 108 µM -0.711239209090082 0.238625505127876 no 2585 0.238468007645215 3690 45595336 SGTC_1174 0739-0097 51.1 µM -0.71507137867924 0.237428324140189 no 2586 0.23728246921287 3710 728447 SGTC_152 4469-0003 551.229 µM -0.716779719400263 0.236895698016689 no 2587 0.236755013686568 3670 697280 SGTC_2923 7992654 58.14 µM -0.717325071007531 0.236725806825861 no 2588 0.236586770557571 3734 2985126 SGTC_605 1315-0399 119 µM -0.71781205642983 0.23657415487365 no 2589 0.236436589242819 3756 24020461 SGTC_2335 9018011 154.17 µM -0.718612582953993 0.236324979404415 no 2590 0.236189829132313 3746 6458208 SGTC_2120 5538279 151.968 µM -0.719677335133816 0.235993783908872 no 2591 0.235861842102617 3715 2058197 SGTC_46 0329-0187a 2.197 µM -0.720227564544252 0.235822733106132 no 2592 0.235692447486973 3741 46494817 SGTC_244 nsc-207895 1.295 µM -0.720566116055373 0.235717520967078 no 2593 0.235588253760994 3584 42640 SGTC_967 1306-0166 352 µM -0.720730657108817 0.235666395656955 no 2594 0.235537623242752 3682 4437607 SGTC_258 haloperidol 50.781 µM -0.720968093736653 0.235592631407889 no 2595 0.235464572791729 3733 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3310 9130229 44.1445 µM -0.722814963099406 0.235019301019612 no 2596 0.234896786581396 3772 7761258 SGTC_3262 9137218 49.47 µM -0.723200079321577 0.234899845187371 no 2597 0.23477848505301 3564 17650664 SGTC_6 0844-0013 19.835 µM -0.723261326397192 0.234880850585736 no 2598 0.234759673969488 3804 1584900 SGTC_932 2857-0803 154 µM -0.725821041248449 0.23408776382981 no 2599 0.233974243042594 3806 674898 SGTC_3177 9107506 49.47 µM -0.727318500453944 0.233624488462133 no 2600 0.233515433724568 3642 8897194 SGTC_2915 7971052 15.16 µM -0.730299030305269 0.232703903911745 no 2601 0.232603710418875 3586 5741558 SGTC_442 cape 100 µM -0.730839309972249 0.232537245972338 no 2602 0.232438654765163 3676 5281787 SGTC_2750 bromebric acid 70.15 µM -0.730860148729446 0.232530819252548 no 2603 0.232432289821487 3772 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3354 9151612 71.43 µM -0.730913327760339 0.232514419166911 no 2604 0.232416047375844 3730 27261949 SGTC_337 1315-0038 354 µM -0.731498858336835 0.232333887677011 no 2605 0.232237250803996 3721 1626437 SGTC_1177 0983-0204 23.6 µM -0.731517352563642 0.232328186785491 no 2606 0.232231604687113 3755 766818 SGTC_2751 anetholtrithion 17.25 µM -0.733641171604995 0.231674032114853 no 2607 0.23158373059594 3727 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3226 9131256 49.47 µM -0.734287396992253 0.231475192952694 no 2608 0.231386798690154 3621 17178073 SGTC_1675 st018485 24.5 µM -0.7345509997743 0.231394111497526 no 2609 0.231306494721497 3781 3323024 SGTC_2126 5251174 33.877 µM -0.734847414809888 0.231302956257989 no 2610 0.231216213397075 3740 790722 SGTC_134 0269-0018 6.916 µM -0.736347289566379 0.230842013464499 no 2611 0.230759686974363 3667 4378915 SGTC_395 anisomycin 6.25 µM -0.736682706449781 0.230739003090398 no 2612 0.230657662933552 3726 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1703 st026983 48.3 µM -0.736744273146074 0.230720098040897 no 2613 0.23063893887663 3739 1104023 SGTC_502 l-744,832 89.3 µM -0.738604564472747 0.230149273746002 no 2614 0.230073575873269 3695 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_3216 9129716 49.47 µM -0.742529474273783 0.228947523901422 no 2615 0.228883300374139 3727 8056934 SGTC_783 0848-0141 92.7 µM -0.742706892446768 0.228893284367194 no 2616 0.2288295779719 3728 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_630 4356-0227 183 µM -0.743360762637233 0.228693448212746 no 2617 0.228631646539321 3737 779312 SGTC_389 tpck 16.7 µM -0.743521697087235 0.228644278367963 no 2618 0.228582945217375 3754 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.744015281230972 0.228493512040073 no 2619 0.228433615156773 3758 521171 SGTC_2112 5488546 200 µM -0.744884864380069 0.228228031935616 no 2620 0.228170662907194 3734 600757 SGTC_246 cycloheximide 667 µM -0.745377535307516 0.228077698542882 no 2621 0.228021760266977 3634 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2616 abietic acid 100 µM -0.74555268859144 0.228024265767449 no 2622 0.227968835900416 3735 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.745655943604247 0.227992769788851 no 2623 0.227937639573858 3870 16725076 SGTC_1343 1487-0095 224 µM -0.746255559345205 0.227809916780977 no 2624 0.227756525787639 3712 4560101 YGL055W OLE1 SGTC_2925 9010536 32.5 µM -0.746413760202903 0.227761687142896 no 2625 0.227708754765176 3735 2994177 SGTC_2770 toltrazuril 17.5 µM -0.747892899375835 0.22731103002141 no 2626 0.227262380421734 3711 68591 Kills coccidiodes. SGTC_1913 st060213 96.1 µM -0.748566133716609 0.227106078670514 no 2627 0.22705937529653 3765 688959 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.749082621682918 0.22694891594022 no 2628 0.226903704347671 3735 77254 SGTC_2184 6075246 200 µM -0.750624391900156 0.226480133888989 no 2629 0.226439368634871 3810 2267320 SGTC_884 0851-0618 334 µM -0.753489247797225 0.225610515322048 no 2630 0.225577985048128 3792 9642473 SGTC_1702 st027038 51 µM -0.753702955474933 0.225545720804693 no 2631 0.225513803419394 3768 5521182 SGTC_2937 9044753 11.33 µM -0.75427817973712 0.2253713695859 no 2632 0.22534110090251 3761 6465530 YGL099W LSG1 SGTC_1377 2944-0135 198 µM -0.754372059580005 0.225342921729213 no 2633 0.225312921988419 3828 1894137 SGTC_3315 9136395 68.55 µM -0.756378322958975 0.224735461773604 no 2634 0.224711200430168 3785 16876844 SGTC_1355 1499-0035 1.68 µM -0.757494980632644 0.224397760878128 no 2635 0.224376685945901 3766 1548538 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.758568227693594 0.224073459882582 no 2636 0.224055442427903 3765 4330530 SGTC_490 phenamil 164 µM -0.758617303135343 0.22405863721877 no 2637 0.224040759452063 3736 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_51 1013-0126 23.419 µM -0.758668140799494 0.224043282883642 no 2638 0.224025549809937 3814 1627850 SGTC_1496 4469-0713 57.4 µM -0.758908597580838 0.223970666600713 no 2639 0.223953617758657 3734 746691 SGTC_937 3122-0005 46.7 µM -0.758935692941009 0.223962484827984 no 2640 0.223945513071486 3791 759535 SGTC_958 1222-0007 33 µM -0.758970896957516 0.223951854801762 no 2641 0.223934983195002 3829 7312461 SGTC_2618 avocadyne 43.43 µM -0.759207252769293 0.22388049342399 no 2642 0.223864294072932 3705 3015189 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.759706192964009 0.223729894086612 no 2643 0.223715113056532 3797 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_114 0364-0001 490.298 µM -0.759757832249732 0.223714310653946 no 2644 0.223699676355851 3823 4003655 SGTC_1353 1498-1206 8.11 µM -0.76070676269858 0.223428057287681 no 2645 0.22341611730749 3815 6756808 SGTC_645 0845-0943 5.41 µM -0.760996977681779 0.223340552969257 no 2646 0.223329436226222 3785 1885106 SGTC_2833 9001315 45.46 µM -0.762792548681114 0.222799594254737 no 2647 0.222793562819775 3774 2989378 SGTC_2183 6420625 130.508 µM -0.763047780901825 0.222722760096298 no 2648 0.2227174503831 3780 2897619 SGTC_2700 st077718 96.8 µM -0.765265538778829 0.222055770537175 no 2649 0.222056720121489 3783 904970 SGTC_545 4218-0007 221 µM -0.76809209230021 0.221207341065676 no 2650 0.22121623728001 3732 2840508 SGTC_2199 6590217 200 µM -0.769208374050464 0.220872785000377 no 2651 0.220884809996203 3715 703109 SGTC_869 0564-0080 44.1 µM -0.769257583132432 0.220858043425007 no 2652 0.22087020622235 3800 6843321 SGTC_881 0833-0569 170 µM -0.769446907404087 0.220801332764919 no 2653 0.22081402563393 3795 5418700 SGTC_1626 st003712 1.76 µM -0.769475488104918 0.220792772355647 no 2654 0.220805545231599 3750 24207035 SGTC_2570 licareol 100 µM -0.77059462623188 0.220457720776219 no 2655 0.220473623700301 3813 443158 SGTC_1866 st057638 64 µM -0.771975412125729 0.220044737970826 no 2656 0.220064495216285 3775 688802 SGTC_3013 9080133 71.4286 µM -0.772017450641593 0.220032171528773 no 2657 0.220052045990137 3833 17050193 SGTC_2551 apiole 73.87 µM -0.772691400768321 0.219830765942409 no 2658 0.219852518525955 3632 10659 A possible DNA adduct former. SGTC_2921 7974240 10.71 µM -0.774373352170182 0.219328587604088 no 2659 0.219355018704469 3854 2979074 YDR527W RBA50 SGTC_903 1134-0042 114 µM -0.774399000532304 0.219320934908182 no 2660 0.219347437256499 3789 701009 SGTC_546 peri-Naphthalide 147 µM -0.775157607442002 0.219094658938737 no 2661 0.219123267303091 3741 223824 A penicillin ester. SGTC_511 blebbistatin 171 µM -0.775204122769674 0.219080788795703 no 2662 0.219109526212383 3844 3476986 A myosin inhibitor. SGTC_3019 9081971 49.47 µM -0.777878269113993 0.218284249500348 no 2663 0.218320390178678 3802 16451803 SGTC_1148 3909-7663 27.7 µM -0.778689657944696 0.218042894087695 no 2664 0.218081274875122 3864 4084526 SGTC_280 3448-3607 3.04 µM -0.779183018699475 0.217896214426889 no 2665 0.217935955891423 3785 626179 SGTC_2427 5545055 42.75 µM -0.779697552404046 0.217743300533268 no 2666 0.217784459933292 3778 5372858 SGTC_1423 4048-0112 5.59 µM -0.780020238798333 0.217647433195797 no 2667 0.217689481252601 3828 X1423 SGTC_1571 st070080 73.4 µM -0.781080333066493 0.217332659843644 no 2668 0.217377624115374 3869 4315245 SGTC_3021 9087658 49.47 µM -0.781845920388369 0.217105497890778 no 2669 0.217152565151767 3746 25237042 SGTC_1850 st056238 17 µM -0.782447699892517 0.216927036663513 no 2670 0.216975755144522 3801 5393177 SGTC_732 3970-1727 52.7 µM -0.783490090301573 0.216618110433035 no 2671 0.216669685360329 3824 1275699 SGTC_1305 1181-0477 144 µM -0.783494567277277 0.216616784170961 no 2672 0.216668371356145 3823 6252086 SGTC_1024 4507-0395 26 µM -0.785346088093431 0.216068691279427 no 2673 0.216125340344626 3882 4201836 SGTC_1231 0242-0792 125 µM -0.785420981684002 0.216046537964481 no 2674 0.216103391464214 3817 3707635 SGTC_2187 6125751 200 µM -0.785875156920791 0.215912222382616 no 2675 0.215970315100489 3820 874498 SGTC_1171 0368-0077 21.4 µM -0.786707833062055 0.215666096492328 no 2676 0.215726458809899 3787 3239779 SGTC_1567 st069303 68.4 µM -0.788165670021813 0.215235574891381 no 2677 0.215299903434188 3891 5581319 SGTC_3048 9093155 49.47 µM -0.789193622959487 0.214932304715597 no 2678 0.214999424297696 3736 25236002 SGTC_3330 9141424 71.43 µM -0.789260699697421 0.214912524137403 no 2679 0.214979825680414 3891 27261020 SGTC_1410 3909-8106 77.9 µM -0.791193887933123 0.214342891590113 no 2680 0.214415428810035 3843 1039210 SGTC_3145 9085516 49.47 µM -0.793124677313883 0.213774843366744 no 2681 0.213852593283274 3880 25236195 SGTC_2127 5253358 187.912 µM -0.793485913204193 0.213668663346039 no 2682 0.213747386687087 3764 20612 SGTC_832 4083-0019 164 µM -0.794090875443028 0.213490912345907 no 2683 0.21357126458883 3896 1990758 SGTC_3010 9080089 71.4286 µM -0.794486217944585 0.213374798736874 no 2684 0.213456214590907 3814 17027233 SGTC_905 2-aminofluorene 215 µM -0.796247805738293 0.212857861333064 no 2685 0.212944008065123 3837 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1886 st057356 49.9 µM -0.796606577101758 0.212752669652036 no 2686 0.21283977820599 3806 24207747 SGTC_14 0354-0009 295 µM -0.797341093609101 0.212537404277542 no 2687 0.212626480199138 3888 1713507 SGTC_1294 1000-1494 117 µM -0.799158987363992 0.212005180021276 no 2688 0.212099114789258 3820 712797 YDL207W GLE1 SGTC_115 0527-0192 112.043 µM -0.799372185031976 0.211942813306042 no 2689 0.212037316944985 3864 4233931 SGTC_1766 st045414 44.774 µM -0.799739964355984 0.211835252045666 no 2690 0.211930736547987 3864 253960 SGTC_495 decylubiquinone 155 µM -0.800287126316595 0.211675287403488 no 2691 0.21177223006836 3856 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2812 7970281 58.44 µM -0.802575432157926 0.2110070600578 no 2692 0.21111008653079 3868 2233435 SGTC_930 2810-3379 265 µM -0.8078386839226 0.20947479527865 no 2693 0.209591726387001 3855 1015764 SGTC_1596 piperlongumine 63 µM -0.808395840803244 0.20931297696747 no 2694 0.209431372757528 3864 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1906 st060206 94.7 µM -0.808505684432525 0.209281083128023 no 2695 0.209399767516845 3846 5133468 SGTC_1189 1431-2119 7.28 µM -0.808701419530505 0.20922425721118 no 2696 0.209343455732972 3862 3107275 SGTC_3323 9138564 53.9225 µM -0.811319512648283 0.20846504471073 no 2697 0.208591103653538 3848 43912313 YNL103W MET4 SGTC_935 2996-0153 430 µM -0.813348810088472 0.207877694429908 no 2698 0.208009049822218 3818 23738523 SGTC_43 0570-0105 72.5 µM -0.813897703733215 0.207718993310713 no 2699 0.207851778141893 3866 1114046 YDL195W SEC31 SGTC_619 1652-1634 108 µM -0.813942871353725 0.20770593722564 no 2700 0.207838839623048 3816 5400454 SGTC_1019 4262-0212 3.4 µM -0.816135144217361 0.207072825083215 no 2701 0.207211422724672 3896 4677213 SGTC_467 ro 31-8220 72.8 µM -0.816230262478725 0.207045381502392 no 2702 0.207184225760985 3789 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3128 9127691 49.47 µM -0.817722597255446 0.206615093932038 no 2703 0.206757802113729 3893 41316314 SGTC_1397 3532-0190 20.1 µM -0.818329712262427 0.206440195034218 no 2704 0.206584472284323 3770 5322280 SGTC_39 0986-0283 58.349 µM -0.819971120543612 0.205967774254864 no 2705 0.206116285378365 3940 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2975 9084847 53.72 µM -0.820311396642618 0.205869918232117 no 2706 0.206019305553366 3943 27211724 SGTC_2423 st077119 87.2 µM -0.820999250622915 0.205672190604052 no 2707 0.205823347532366 3798 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2828 7998861 71.43 µM -0.821890512829414 0.205416159810205 no 2708 0.205569606477813 3770 2988188 SGTC_1726 st035556 14.5795 µM -0.822512309437253 0.20523764990788 no 2709 0.205392691914382 4001 5919439 SGTC_739 1486-1183 203 µM -0.824316690217672 0.204720157172339 no 2710 0.204879818808395 3825 4346692 SGTC_1534 6-azauridine 81.6 µM -0.825796000831218 0.204296473468826 no 2711 0.204459911535694 3898 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.826020026330154 0.204232356730318 no 2712 0.204396365836298 3904 5282362 SGTC_3164 9100705 49.47 µM -0.826080099655601 0.204215165610429 no 2713 0.204379327804322 3884 17174235 SGTC_1930 st074634 34.3 µM -0.826408747778144 0.204121131979484 no 2714 0.204286131396007 3798 684253 YOR116C RPO31 SGTC_2123 5259487 200 µM -0.826485852849396 0.204099074217564 no 2715 0.204264269986707 3873 2173474 SGTC_90 0870-0863 4.608 µM -0.826578184132657 0.204072662499337 no 2716 0.204238093360261 3858 1738164 SGTC_1910 st062352 60.4 µM -0.828466814676994 0.203532859374335 no 2717 0.203703090580797 3816 2245730 SGTC_466 geldanamycin 89.2 µM -0.82855156606928 0.203508655950109 no 2718 0.203679102192275 3756 5288382 HSP90 inhibitor. SGTC_572 0960-0087 17.7 µM -0.82885525355199 0.203421942541537 no 2719 0.20359315904924 3882 6796365 SGTC_336 4111-0029 111 µM -0.831850118220962 0.202567984990325 no 2720 0.202746775281307 3868 3131175 SGTC_758 0868-0029 16 µM -0.831878853521753 0.202559801781764 no 2721 0.202738664545721 3947 762687 SGTC_2634 4'-methoxyflavone 100 µM -0.833129084225276 0.202203953773227 no 2722 0.202385966112922 3894 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3326 9140064 16.379 µM -0.833366600935396 0.202136392670298 no 2723 0.202319002561556 3844 1868434 SGTC_2258 7960471 200 µM -0.835455793262294 0.201542708655266 no 2724 0.201730563594233 3916 2974708 SGTC_1472 k841-0093 193 µM -0.836000407969058 0.201388117792951 no 2725 0.2015773367725 3997 X1472 SGTC_3150 9097574 49.47 µM -0.836113514040802 0.201356021138662 no 2726 0.201545523234832 3881 17217476 SGTC_1035 k081-0041 55.2 µM -0.837522975636128 0.200956308672801 no 2727 0.201149333938649 3858 731709 SGTC_1330 1469-0054 61.8 µM -0.838075815455587 0.200799657621141 no 2728 0.200994062337096 3911 7102664 SGTC_3348 9149464 3.537 µM -0.84083768169059 0.200018161637733 no 2729 0.200219437013609 3863 1951442 SGTC_682 0kpi-0099 17 µM -0.841307506270747 0.199885402587082 no 2730 0.2000878432931 3936 1714895 YML126C ERG13 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.844626865850538 0.198948956759626 no 2731 0.19915960206675 3991 688801 SGTC_1400 3771-8998 51.5 µM -0.845453926670072 0.198716041438363 no 2732 0.198928723229771 3811 670767 SGTC_3311 9131146 2.8755 µM -0.845687195204081 0.198650378528548 no 2733 0.198863634137886 3880 4900406 YPR165W RHO1 SGTC_1215 3852-0577 11.2 µM -0.847260659054953 0.198207805077951 no 2734 0.198424924785905 3968 2884876 SGTC_1483 3453-0561 55.9 µM -0.848153444424615 0.197956953235238 no 2735 0.198176260424966 3917 4546991 SGTC_449 xestospongin c 11.1929 µM -0.848260503315749 0.197926885067963 no 2736 0.198146454327102 3915 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1064 honokiol 6.76 µM -0.848436183692309 0.197877550100349 no 2737 0.198097549294263 3899 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1814 st052110 31.539 µM -0.849231870045729 0.197654196661182 no 2738 0.197876141342231 3822 674163 SGTC_772 k072-0172 35.3 µM -0.849824548268392 0.197487927759351 no 2739 0.197711319689106 3944 5861980 SGTC_1812 st052057 4.327 µM -0.849967283329948 0.197447897756618 no 2740 0.197671637988949 3915 3645418 SGTC_699 0375-0592 111 µM -0.850259000041222 0.197366101159576 no 2741 0.19759055295114 3945 762578 SGTC_687 k029-0044 34.9 µM -0.854938383386046 0.196056817205494 no 2742 0.196292629956424 3969 5829338 SGTC_2871 9038510 12.99 µM -0.855188701042485 0.195986927493703 no 2743 0.196223345168437 3858 4945164 SGTC_1748 st037455 53.6035 µM -0.855358552522089 0.195939512875454 no 2744 0.196176340854473 3943 580690 SGTC_149 3970-0822 46.1 µM -0.856507375346899 0.195618997840659 no 2745 0.195858597530605 3927 3114250 YBL034C STU1 SGTC_326 k292-0812 17.5 µM -0.858818204491151 0.194975254512224 no 2746 0.19522041116271 3880 3579357 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.859923447892731 0.194667815254377 no 2747 0.194915621103954 3935 551469 SGTC_426 0988-0037 14.6 µM -0.861787030035011 0.194150101629532 no 2748 0.194402361711536 3909 5383008 SGTC_1082 camptothecin 424.86 nM -0.862538179475034 0.193941665446382 no 2749 0.194195716389771 3840 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2779 methotrexate 400 µM -0.863811160395436 0.19358873796195 no 2750 0.193845817997437 3948 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_355 1311-2252 105 µM -0.865203895555683 0.193203058239316 no 2751 0.193463443821536 3928 5338538 SGTC_3117 9124945 49.47 µM -0.865237164893932 0.193193850949809 no 2752 0.193454315385474 3840 17592065 SGTC_3073 9114972 49.47 µM -0.865655085402848 0.193078214262338 no 2753 0.193339668801732 3888 41905075 SGTC_787 4152-0075 138 µM -0.865688499610554 0.193068970529192 no 2754 0.193330504196283 3952 9566539 SGTC_2035 5154463 94.595 µM -0.866161509001432 0.192938145820705 no 2755 0.193200799065411 3955 2769623 SGTC_2471 5466956 24.79 µM -0.867765722402985 0.192494856587501 no 2756 0.192761299245386 3884 724419 SGTC_1147 3809-1045 12.3 µM -0.869688810300067 0.191964274718515 no 2757 0.19223524446623 3897 325925 SGTC_837 0091-0265 12.5 µM -0.870059877137357 0.191862000122391 no 2758 0.192133841435529 3892 759367 SGTC_2743 auranofin 4.32 µM -0.872224939767344 0.191265924200444 no 2759 0.191542838230638 3871 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1058 3448-5425 97.3 µM -0.872432757885183 0.19120876836333 no 2760 0.191486168176822 3803 7279705 SGTC_517 1365-0151 113 µM -0.87254077435227 0.191179064927843 no 2761 0.191456717155873 4007 768657 SGTC_485 niflumic acid 177 µM -0.873108800779539 0.191022909967804 no 2762 0.191301888686764 3984 4488 A COX2 inhibitor. SGTC_492 tmb-8 126 µM -0.873560843581267 0.190898695738593 no 2763 0.191178729037112 3869 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_71 0417-1750 47.813 µM -0.874174528655512 0.19073014408109 no 2764 0.191011607555155 3909 6811472 SGTC_2625 euphol 100 µM -0.875008631113081 0.190501200172556 no 2765 0.190784604723922 3970 6708538 A triterpene alcohol. SGTC_752 1896-0090 130 µM -0.875213130868989 0.190445094977185 no 2766 0.190728974941037 3910 772567 SGTC_386 1509-0011 3.07 µM -0.87686390534665 0.189992571085961 no 2767 0.190280281661626 3966 3107280 SGTC_491 tetrandrine 80.3 µM -0.877475857024407 0.189824985913787 no 2768 0.190114113335991 3949 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_918 glabranin 770.725 nM -0.879748319662271 0.189203459701806 no 2769 0.189497833461678 3971 124049 Also referred to as licorice root. SGTC_1194 1488-0194 225 µM -0.880336286956943 0.189042852928696 no 2770 0.189338580234231 3901 1391452 SGTC_2766 oltipraz 83.91 µM -0.881483473937266 0.188729733809784 no 2771 0.189028097446292 3886 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2645 abamectin 100 µM -0.884751445489483 0.187839510613616 no 2772 0.188145351099803 3893 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2089 5281248 129.67 µM -0.884901772689221 0.18779862269127 no 2773 0.188104805930156 3936 2737878 SGTC_1862 st057513 3.81 µM -0.890557054300024 0.186264421761357 no 2774 0.186583423621082 3933 5393163 SGTC_3336 9143619 71.43 µM -0.894258640841938 0.18526444944593 no 2775 0.185591761674859 3980 45595730 SGTC_184 1494-0393 24.714 µM -0.894553152643175 0.185185031404989 no 2776 0.185513002121219 3951 3090647 SGTC_1345 1488-0192 31.4 µM -0.895351130678416 0.184969954957764 no 2777 0.185299707828962 3984 658348 SGTC_994 3910-0338 138 µM -0.895723960391658 0.18486952058799 no 2778 0.185200105106273 4056 3479481 SGTC_13 0199-0087 65 µM -0.895996246777833 0.184796192403444 no 2779 0.185127383887733 4007 4589825 SGTC_1818 st052136 56.3 µM -0.898047627710316 0.184244325863035 no 2780 0.18458007916594 3775 674169 SGTC_2772 vinpocetine 57.06 µM -0.898308498124142 0.184174219570062 no 2781 0.184510551597983 3968 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_340 k038-0059 454 µM -0.898544741882149 0.184110745770786 no 2782 0.184447601619702 3954 23733424 SGTC_1043 0916-0009 19.3 µM -0.899401708979014 0.18388061079199 no 2783 0.184219364621387 4003 3101130 SGTC_728 3030-5151 22.5 µM -0.900053965180611 0.183705570207928 no 2784 0.184045766356899 4005 3125388 SGTC_1494 4358-1428 177 µM -0.900059672750478 0.183704038973092 no 2785 0.184044247734407 3987 1564571 SGTC_1379 2144-0755 36.5 µM -0.902492400952131 0.183052107377454 no 2786 0.183397678168373 4054 5392327 SGTC_2430 5571206 200 µM -0.904588706847391 0.182491490823849 no 2787 0.18284166018157 4004 1731771 SGTC_1202 1988-0068 29.6 µM -0.906915913080485 0.181870382057314 no 2788 0.182225632692098 3939 2850480 SGTC_2157 5649910 96.377 µM -0.90810261392754 0.181554172728086 no 2789 0.181912004788373 3970 2858091 SGTC_1369 1866-0067 208 µM -0.908382566003666 0.181479626648125 no 2790 0.181838066737152 3956 3531355 SGTC_692 k241-0027 77.8 µM -0.909634698479552 0.181146441383879 no 2791 0.181507596544633 4031 3600480 SGTC_1719 st032227 49.2 µM -0.910321949478829 0.180963730817177 no 2792 0.181326373100219 3985 3125804 SGTC_1041 0206-0046 107 µM -0.911475838841769 0.180657220951575 no 2793 0.181022355185562 4003 50494 SGTC_1559 coumarin 343 70.1 µM -0.912061176869838 0.180501861005429 no 2794 0.180868256985098 4013 108770 A hepatotoxic, DNA x-linker. SGTC_321 4534-3890 65.3 µM -0.912987062727334 0.180256284312313 no 2795 0.180624672878656 4001 699746 SGTC_1010 4112-3296 15.2 µM -0.913041713186117 0.18024179569229 no 2796 0.180610301747119 4062 704384 SGTC_2362 9071156 126 µM -0.914056420527854 0.179972915009831 no 2797 0.180343599987862 4038 653133 SGTC_3349 9149703 23.001 µM -0.916553993135952 0.179312173187413 no 2798 0.179688200997208 3986 4910494 SGTC_1721 st082152 9.2685 µM -0.917340290219409 0.179104471576017 no 2799 0.179482175461228 3936 5296051 SGTC_225 nsc-122657 1.016 µM -0.918411938642985 0.178821637775552 no 2800 0.179201621381694 3996 275685 SGTC_2814 7977482 42.97 µM -0.91914321943462 0.17862879665615 no 2801 0.179010332864537 4064 6456762 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.919242736382918 0.178602563840707 no 2802 0.17898431114475 3971 2724278 An inhibitor of dopamine biosynthesis. SGTC_2429 5902844 64.44 µM -0.920164903284566 0.178359594688516 no 2803 0.178743295913498 4027 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2119 5528445 120.635 µM -0.92033950232672 0.178313615432691 no 2804 0.178697686160934 4014 791935 SGTC_2642 cholecalciferol 100 µM -0.920786694493883 0.178195885033186 no 2805 0.178580901508327 3993 9821465 A vitamin D precursor, similar to steriods. SGTC_1271 0832-2808 169 µM -0.921384733831613 0.178038518323093 no 2806 0.17842479811709 4036 3663794 SGTC_2435 5706476 10.6 µM -0.923930980400096 0.177369485936876 no 2807 0.177761125961581 3992 5725375 SGTC_841 0251-0215 91.2 µM -0.925301751688957 0.177009970658942 no 2808 0.177404483922095 4029 3888614 SGTC_3127 9126946 49.47 µM -0.927150995376746 0.17652569546575 no 2809 0.176924071082802 4010 27243249 SGTC_576 1073-0113 22.7 µM -0.928397195407546 0.176199816896318 no 2810 0.176600786403031 4156 5439563 SGTC_3195 9113082 49.47 µM -0.929227281755894 0.175982962555165 no 2811 0.176385655841852 3936 17018038 SGTC_1490 4089-0339 670 nM -0.93083720561948 0.175562862981641 no 2812 0.175968890375725 3942 742542 SGTC_1032 k061-1018 98.7 µM -0.934704425323368 0.174556335631282 no 2813 0.174970322833964 4129 4005393 SGTC_2021 4019055 173 µM -0.938281555731346 0.173628579705204 no 2814 0.174049867904356 3907 44827708 YER133W GLC7 SGTC_487 nimodipine 119 µM -0.940318791512779 0.17310161199249 no 2815 0.173527031717247 3956 4497 L-type voltage-gated calcium channels inhibitor SGTC_806 3966-4455 5.86 µM -0.941263036438254 0.172857711920946 no 2816 0.173285040053542 3996 714982 SGTC_3246 9135460 32.98 µM -0.941763931200716 0.172728418896648 no 2817 0.173156757706673 3959 41446951 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.942246592605127 0.172603890678773 no 2818 0.173033202275506 4026 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2940 9060638 45.86 µM -0.942579489687305 0.172518035509665 no 2819 0.172948017419136 4018 4027022 SGTC_3037 9091026 49.47 µM -0.948464810922651 0.171004691791136 no 2820 0.171446439396617 3986 25236398 YIL048W NEO1 SGTC_1127 asiatic acid 681.4 nM -0.949741909419625 0.170677425068907 no 2821 0.1711217045962 3991 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1711 st032263 62.8 µM -0.949863277762574 0.170646344333251 no 2822 0.171090864086941 4026 3958979 SGTC_2409 alverine citrate 63.97 µM -0.951137782915702 0.17032018020424 no 2823 0.170767218484265 4202 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3042 9091578 49.47 µM -0.951512648715813 0.170224322728773 no 2824 0.170672100341343 4008 25236497 SGTC_187 1488-2104 32.728 µM -0.955280381516565 0.169262790561847 no 2825 0.169717962951241 4042 2852859 SGTC_646 4092-0839 27.3 µM -0.957925523467558 0.168589832928857 no 2826 0.169050157528217 4084 877796 SGTC_1308 1187-1617 41.4 µM -0.95842634348307 0.16846261188613 no 2827 0.168923908333171 4049 2882570 SGTC_594 1487-1584 10.8 µM -0.958647428383331 0.168406470334425 no 2828 0.168868195429848 4001 5013332 SGTC_26 0302-0163 425.158 µM -0.962251942618885 0.167492849704273 no 2829 0.16796153143945 4091 3100915 SGTC_199 4063-0024 41.6 µM -0.962484857447098 0.167433923830776 no 2830 0.167903053016921 4069 306215 SGTC_1846 st056244 14.8 µM -0.962722605710976 0.167373788908818 no 2831 0.167843374572293 4075 5393182 SGTC_3178 9107506 49.47 µM -0.964691437851641 0.166876336764295 no 2832 0.16734969253176 4074 8897194 SGTC_2495 cafestol 54.53 µM -0.965003714341865 0.166797523592893 no 2833 0.167271475687355 4068 16667697 An anti-infammatory. SGTC_1126 isoteolin 1.0172 µM -0.968434362069634 0.165933269034796 no 2834 0.166413742612491 3992 133323 SGTC_2235 salicylic acid 500 µM -0.968518024434845 0.165912228884376 no 2835 0.166392860819393 4077 338 A COX inhibitor and kinase inhibitor. SGTC_1615 st002656 86.5 µM -0.971937537615888 0.165053735181499 no 2836 0.16554081190207 4052 1584458 SGTC_925 2064-1272 59.6 µM -0.973703317986388 0.164611551169002 no 2837 0.165101934689747 4034 6815817 SGTC_176 1486-1328 72.834 µM -0.976329909956771 0.163955225566344 no 2838 0.164450501260919 4131 22310231 SGTC_2071 5230951 39.92 µM -0.976587749374093 0.163890889003865 no 2839 0.164386643219218 4087 1799272 SGTC_2876 9059903 25.97 µM -0.976647352217805 0.163876019124974 no 2840 0.164371883912722 4017 6916095 SGTC_35 0133-0054 64.071 µM -0.978476035792857 0.163420219728802 no 2841 0.163919469022791 4082 99677 SGTC_1306 1185-0270 9.02 µM -0.978973248568248 0.163296431960545 no 2842 0.16379659881737 4091 1548076 SGTC_3166 9102297 49.47 µM -0.984478155363998 0.161929984118743 no 2843 0.162440233470176 4079 25237072 SGTC_1670 st016595 4.04 µM -0.986254326474384 0.161490690565427 no 2844 0.162004163194347 4080 597879 SGTC_254 nsc-64875 3.808 µM -0.988067705351617 0.161042996951195 no 2845 0.161559745357172 4082 56993 SGTC_1654 st012436 41.8 µM -0.991251314188428 0.160258977082267 no 2846 0.160781439817089 4016 4323132 SGTC_1658 st012944 20 µM -0.994747156741106 0.159400942814423 no 2847 0.159929626477178 3951 24207260 SGTC_446 go6976 132 µM -0.995030285711251 0.159331582358693 no 2848 0.159860767389996 4107 3501 A protein kinase C inhibitor. SGTC_1386 3228-0095 33.8 µM -0.996998664080318 0.158849918741783 no 2849 0.159382579195067 4103 870181 SGTC_2130 NSC 7 2.4545 µM -0.997125227826957 0.158818981189762 no 2850 0.159351864496768 4151 21448 SGTC_1382 3002-2117 298 µM -0.998123705125902 0.158575049446634 no 2851 0.159109688288149 4158 1497314 SGTC_2908 7930301 100 µM -0.998317843618692 0.158527649230841 no 2852 0.159062628875876 4071 2223178 SGTC_222 nsc-310342 10.666 µM -0.999669956483246 0.158197779558412 no 2853 0.15873512797911 4084 432556 SGTC_1156 4092-0367 4.88 µM -1.00150566003242 0.157750651622065 no 2854 0.158291202557713 4100 1357585 SGTC_538 2922-0838 53.3 µM -1.00248846849276 0.157511607463142 no 2855 0.158053866605432 4091 777039 SGTC_649 1123-0311 367 µM -1.00286047875816 0.157421187186368 no 2856 0.15796409175574 3996 693629 YIL048W NEO1 SGTC_790 1575-0012 79.1 µM -1.00381641127216 0.15718899611199 no 2857 0.157733556277792 4150 378741 YLR208W SEC13 SGTC_2782 7736369 71.43 µM -1.00470819310492 0.156972590046882 no 2858 0.157518690917268 4134 2950836 YOL077C BRX1 SGTC_2440 5628896 157.78 µM -1.00484264331252 0.156939980421888 no 2859 0.157486313260692 4079 5522048 SGTC_2794 7785382 27.27 µM -1.00532796545946 0.156822307211259 no 2860 0.157369476690391 4061 2205081 SGTC_860 0443-0016 25.1 µM -1.00626171574617 0.156596069616148 no 2861 0.157144845729904 4126 5337942 SGTC_2552 juarezic acid 87.02 µM -1.00630056200136 0.156586662246359 no 2862 0.157135505113165 4080 1549512 SGTC_370 0180-0345 38.7 µM -1.00641182497978 0.156559719829521 no 2863 0.157108753851241 3959 3989527 SGTC_1992 st073643 23.3 µM -1.00766039685461 0.156257586484058 no 2864 0.156808761709423 4066 3161292 SGTC_180 1486-1293 102.781 µM -1.01047070265247 0.15557894599913 no 2865 0.156134914487031 3982 4140536 SGTC_2055 5235184 200 µM -1.01354569476859 0.154838619108465 no 2866 0.155399790778808 4166 2836034 SGTC_1284 0929-0043 16 µM -1.01617754436721 0.154206833284256 no 2867 0.154772423858432 4075 1239883 SGTC_156 3474-0145 5.642 µM -1.0165383627931 0.154120350489848 no 2868 0.154686544407591 3923 2265471 SGTC_784 4579-0127 173 µM -1.01666859326385 0.154089144070008 no 2869 0.154655555606508 4164 1948547 SGTC_2646 retinol 96.75 µM -1.01804365014994 0.153759901752898 no 2870 0.154328606307062 4114 445354 A vitamin A analog and teratogen. SGTC_580 1123-0028 41 µM -1.020799896896 0.153101351892005 no 2871 0.153674626639466 4160 1677248 YPR107C YTH1 SGTC_920 mycophenolic acid 780.421 nM -1.02129549326936 0.152983137671952 no 2872 0.15355723049082 4120 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1971 st069429 63.5 µM -1.02386095088198 0.152372168650802 no 2873 0.152950478262372 4094 1246522 YGL099W LSG1 SGTC_679 0422-0091 41.4 µM -1.02570006894901 0.151935176908378 no 2874 0.152516490927473 4123 627384 YHR062C RPP1 SGTC_3043 9092303 49.47 µM -1.02647935376112 0.151750262883146 no 2875 0.152332845291037 4116 25236084 SGTC_1329 1447-1697 50.6 µM -1.02737195498025 0.151538644198117 no 2876 0.152122676024574 4126 2840515 SGTC_3114 9122766 49.47 µM -1.02815315991354 0.151353596509419 no 2877 0.151938893882623 4121 17176985 SGTC_2829 7992743 58.44 µM -1.02826160200472 0.151327921204235 no 2878 0.151913394032712 4141 16462845 SGTC_2843 9000894 45.46 µM -1.02977793468245 0.150969209958719 no 2879 0.15155713053572 4039 2242070 SGTC_2589 lobaric acid 100 µM -1.03269092770587 0.150281686787976 no 2880 0.150874280256408 4127 73157 A novel microtubule depolymerizer. SGTC_541 4513-1321 94 µM -1.0344660690658 0.149863743579384 no 2881 0.150459165685031 4103 747515 SGTC_468 gf-109203x 121 µM -1.03448843219915 0.149858483303179 no 2882 0.150453940952294 4105 2396 A protein kinase C inhibitor. SGTC_2086 5274770 176.623 µM -1.03589617370382 0.149527600947798 no 2883 0.150125291446784 4160 689278 SGTC_1915 st067105 30.6 µM -1.03653779809917 0.149376952333711 no 2884 0.149975657534592 4073 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2121 5257820 149.641 µM -1.03669384972266 0.14934032790211 no 2885 0.149939279608815 4177 791256 SGTC_206 4546-0025 72.014 µM -1.03688889989847 0.149294559161459 no 2886 0.149893818821969 4181 6620745 YIL048W NEO1 SGTC_2115 tiliquinol 12.7705 µM -1.03787135580547 0.149064167192749 no 2887 0.149664975366461 4102 71208 A bioactive hydroxyquinoline. SGTC_3053 9095903 49.47 µM -1.03809841509914 0.14901095419275 no 2888 0.149612119624927 4225 17174018 SGTC_74 000s-0487 160.283 µM -1.03952955666002 0.14867584782764 no 2889 0.149279259643944 4018 677548 SGTC_2337 9009472 200 µM -1.04028097671409 0.148500102266697 no 2890 0.149104689818294 4111 5742383 SGTC_80 0159-0065 512.242 µM -1.04059450607553 0.148426813675445 no 2891 0.14903189104295 4012 1548079 SGTC_257 daunorubicin 18.5 µM -1.04185068531803 0.14813342000647 no 2892 0.14874045537996 4148 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1507 4075-3230 155 µM -1.0456019849256 0.147259576350862 no 2893 0.147872416237344 4050 659771 SGTC_1277 0873-0036 22 µM -1.04583046426975 0.147206465262647 no 2894 0.147819656620558 4216 5965735 SGTC_2738 aclarubicin 5.55 µM -1.04833386697865 0.146625378787143 no 2895 0.147242405649666 4101 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1769 st044406 64.4 µM -1.04864352946422 0.146553607475447 no 2896 0.147171106803807 4109 670903 SGTC_591 4299-0174 154 µM -1.0490471914576 0.146460085051174 no 2897 0.14707819961267 4149 5509088 SGTC_3149 9097855 49.47 µM -1.05172488588005 0.145840717929716 no 2898 0.146462894972115 4144 25236625 YMR079W SEC14 SGTC_1948 st076329 66.6 µM -1.05207890414045 0.145758963285464 no 2899 0.146381675001226 4001 24208413 SGTC_22 0964-0034 14.468 µM -1.0521555358256 0.145741270525765 no 2900 0.14636409790366 4149 138402 SGTC_2032 5185112 25.99 µM -1.05288362458509 0.14557324106856 no 2901 0.1461971660447 4023 5718189 SGTC_1094 duloxetine 25.4 µM -1.0552758720259 0.145022071924132 no 2902 0.145649586362009 4155 60834 A selective serotonin reuptake inhibitor. SGTC_1001 4048-4355 44.4 µM -1.05615913422519 0.144818925565677 no 2903 0.145447758766524 4128 21824233 SGTC_3337 9144342 33.5465 µM -1.05732719010837 0.144550572327604 no 2904 0.145181144098393 4154 17682949 SGTC_2793 7325131 81.82 µM -1.05761834960575 0.144483732524671 no 2905 0.145114736707714 4116 4176441 SGTC_1564 D-Arginine 115 µM -1.05981097605382 0.143981052919767 no 2906 0.144615301179081 4159 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1882 5615643 20 µM -1.06083504603774 0.143746680123775 no 2907 0.144382436111833 4111 2253075 SGTC_1845 st056753 3.01 µM -1.06157333513688 0.143577872075548 no 2908 0.144214712109746 4128 5375839 SGTC_3055 9094636 49.47 µM -1.06181341453846 0.143523007332536 no 2909 0.144160199351824 4183 25236176 SGTC_1075 aripiprazole 15.2 µM -1.06201443382812 0.143477079786036 no 2910 0.144114566324047 4196 60795 An atypical antipschotic. YIL048W NEO1 SGTC_917 harmaline 728.087 nM -1.06487949118086 0.142823569034519 no 2911 0.14346523348267 4123 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_465 cgp-37157 41 µM -1.06787852147562 0.142141657942543 no 2912 0.142787656139467 4107 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_949 1165-0505 146 µM -1.07066890345897 0.141509170675788 no 2913 0.142159164859076 4175 6244267 SGTC_1976 st070609 63.5 µM -1.07146033028233 0.141330128079136 no 2914 0.141981249275928 4070 682556 SGTC_189 3970-0742 2.116 µM -1.07351257940935 0.140866568245819 no 2915 0.141520598831152 4095 2891807 SGTC_952 1185-0122 232 µM -1.07479386186351 0.140577677147674 no 2916 0.141233514594769 4115 678600 SGTC_1512 0259-0544 12.2 µM -1.07681882052132 0.140121929702537 no 2917 0.140780607771925 4141 18476 SGTC_1405 3909-7894 12 µM -1.08023464199541 0.139355424552468 no 2918 0.140018852847103 4169 7104060 SGTC_577 r071-0003 38.6 µM -1.08290090709307 0.138759104632547 no 2919 0.139426204614161 4174 4568517 YMR134W ERG29 SGTC_1417 3966-0327 90.4 µM -1.08317918864487 0.138696966261164 no 2920 0.139364447636225 4269 651118 SGTC_505 gw-5074 63.9 µM -1.08330079091091 0.138669819256959 no 2921 0.139337467183417 4202 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1200 1643-0193 18.4 µM -1.0837650956226 0.138566199205347 no 2922 0.139234482456828 4207 5403974 SGTC_1422 4031-0024 15.5 µM -1.08433905871883 0.138438179349317 no 2923 0.139107246649152 4098 782427 SGTC_2777 climbazole 1.536 µM -1.08488885510455 0.138315625376357 no 2924 0.138985442337615 4029 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_726 3448-4391 34.2 µM -1.0853933992569 0.138203223577947 no 2925 0.138873727314891 4298 1356692 SGTC_2624 nerol 100 µM -1.08843206812528 0.137527589369832 no 2926 0.138202205355444 4092 637566 A natural product oil. SGTC_755 1995-0008 37.3 µM -1.09097606003399 0.136963681155229 no 2927 0.137641708412899 4157 689533 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.09344113529208 0.136418775124289 no 2928 0.137100080465448 4248 1273210 SGTC_2891 9063876 19.48 µM -1.0941114019555 0.136270869152914 no 2929 0.136953061169094 4181 6472478 SGTC_2286 7945697 125 µM -1.09984145113131 0.135010913108 no 2930 0.135700604174596 4224 1245733 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.10031126883161 0.134907962463251 no 2931 0.135598261962571 4112 5355888 SGTC_3237 9133362 49.47 µM -1.10141694907404 0.134665888488963 no 2932 0.135357616049448 4169 43845137 SGTC_1961 st076550 68.7 µM -1.10326290192369 0.134262406310234 no 2933 0.134956506045196 4223 1579337 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.10380788211947 0.13414344527511 no 2934 0.134838242479086 4222 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_232 clozapine 119 µM -1.10643969130503 0.133569979915587 no 2935 0.134268126945604 4154 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_335 4077-0256 27.6 µM -1.10742359326259 0.133356023447138 no 2936 0.134055414996038 4168 3121989 SGTC_2016 5121758 140 µM -1.10768864488541 0.133298426424036 no 2937 0.133998152505206 4110 2795203 SGTC_478 N-arachidonylglycine 10 µM -1.10772010293095 0.133291591572203 no 2938 0.133991357337368 4181 5283389 SGTC_2015 5119600 184 µM -1.1079676107953 0.133237824247067 no 2939 0.133937902089338 4240 2828786 SGTC_18 0111-0177 500 nM -1.10827477673756 0.133171117866171 no 2940 0.133871582633364 4272 721752 SGTC_886 0866-0150 153 µM -1.11072550505057 0.132639723158335 no 2941 0.133343260196469 4269 271463 SGTC_740 k014-0057 261 µM -1.11109565030448 0.132559591209388 no 2942 0.13326358998011 4199 4012779 SGTC_439 amiodarone 34.4 µM -1.11346445477265 0.13204756357391 no 2943 0.132754503080743 4065 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2692 st077426 47.7 µM -1.11406775641814 0.131917375441104 no 2944 0.13262505999213 4231 25238571 SGTC_2678 equilin 100 µM -1.11456801323507 0.131809490801983 no 2945 0.132517791936391 4200 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1912 st060209 90.8 µM -1.11690018971982 0.131307340554984 no 2946 0.132018501754352 4206 688787 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.11714816402238 0.131254026018152 no 2947 0.131965489925017 4283 4213774 SGTC_919 tnp00227 403.569 nM -1.11847012469097 0.130970056440833 no 2948 0.131683129569425 4181 1269246 A methoxyflavone. YNL221C POP1 SGTC_197 4544-0043 41.561 µM -1.11880442910704 0.130898312010435 no 2949 0.131611790881166 4206 896523 SGTC_369 0957-0393 4.5 µM -1.11912859424781 0.13082876949117 no 2950 0.131542641333244 4241 6997992 SGTC_2879 9041815 71.43 µM -1.11987003047738 0.130669806620584 no 2951 0.131384575553584 4221 4942971 SGTC_2293 7624732 200 µM -1.12268075141181 0.130068404916697 no 2952 0.130786552927183 4106 894453 SGTC_2270 7924575 90.91 µM -1.12567737712022 0.129429338637646 no 2953 0.130151051426537 4212 1262135 SGTC_1972 st070201 17.4 µM -1.12754335515929 0.129032497479333 no 2954 0.129756410359928 4229 2829099 SGTC_2504 purpurogallin 52.29 µM -1.12859136004563 0.128809986629811 no 2955 0.129535128554913 4116 5281571 An antioxidant. SGTC_2204 7233102 200 µM -1.12930055679896 0.128659562117806 no 2956 0.129385533055601 4139 2172480 SGTC_1984 st072354 53.1 µM -1.12937571278193 0.128643628268697 no 2957 0.129369686932322 4102 5762938 SGTC_190 3970-0790 3.722 µM -1.13011937716435 0.128486037502784 no 2958 0.129212962892655 4180 2832352 SGTC_2061 5245884 80.95 µM -1.13510957061795 0.127432026411707 no 2959 0.128164706019042 4202 573863 SGTC_2052 5265182 7.135 µM -1.13556646589261 0.127335823952952 no 2960 0.128069025045245 4226 1239884 SGTC_372 0155-0182 15.9 µM -1.13718440720373 0.126995561455065 no 2961 0.127730601989632 4125 771486 SGTC_2898 9056270 58.44 µM -1.13914767326514 0.12658352565689 no 2962 0.127320783124416 4214 19154699 SGTC_1991 st073000 8.92 µM -1.13931067726432 0.126549357492371 no 2963 0.127286798280926 4296 4301969 YIL048W NEO1 SGTC_2533 agelasine 13.65 µM -1.14551226079998 0.12525417894066 no 2964 0.125998509718361 4314 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2215 7188065 200 µM -1.14629103100074 0.125092192013476 no 2965 0.125837376382803 4270 940217 SGTC_3139 9095020 49.47 µM -1.14940286078105 0.124446381137422 no 2966 0.125194950485433 4035 25236292 SGTC_2175 5807670 165.306 µM -1.15815841697655 0.122641824614696 no 2967 0.123399697167799 4218 241186 SGTC_2941 9056145 11.23 µM -1.15874535626614 0.122521513914603 no 2968 0.12327999850102 4171 2119517 SGTC_1958 st076513 41.9 µM -1.16239061371785 0.121776163997078 no 2969 0.12253841711929 4200 732122 YGL099W LSG1 SGTC_3008 9078912 71.4286 µM -1.16378304507958 0.121492294587485 no 2970 0.122255972445018 4251 16648731 SGTC_235 0330-0087 5 mM -1.16389712643992 0.12146905791069 no 2971 0.122232852134475 4295 46494818 YHR062C RPP1 SGTC_2946 9065502 71.43 µM -1.16866448788935 0.120500809348649 no 2972 0.121269417520132 4081 16489101 SGTC_2436 5633522 8.09 µM -1.1753163666108 0.119158918537161 no 2973 0.119934084513394 4257 5724242 SGTC_3124 9127567 49.47 µM -1.17603718408978 0.119014143212598 no 2974 0.119790008721971 4250 17592030 SGTC_255 tunicamycin 200.472 nM -1.1796715221597 0.118286082633953 no 2975 0.119065442243187 4190 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3044 9093193 49.47 µM -1.18004543270426 0.11821135682942 no 2976 0.118991072808091 4294 25236277 SGTC_1773 st048542 73.5835 µM -1.18502829007636 0.117218721073927 no 2977 0.118003130859388 4236 3237138 SGTC_2380 9035439 200 µM -1.18521630530841 0.117181382478686 no 2978 0.117965967362308 4367 6462575 SGTC_2986 9022445 71.43 µM -1.185670076046 0.117091301287616 no 2979 0.117876308165696 4272 6459286 SGTC_1868 st057644 42.7 µM -1.18948719589486 0.116335480205129 no 2980 0.11712400329228 4299 688665 SGTC_3183 9108214 49.47 µM -1.18955022300514 0.116323029436327 no 2981 0.117111610078556 4210 4974831 SGTC_599 1935-0052 86.5 µM -1.190593816792 0.11611700882269 no 2982 0.116906540079617 4272 9557311 SGTC_1788 fluconazole 20 µM -1.19224280921633 0.115792001848838 no 2983 0.11658302606188 4303 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3157 9099274 49.47 µM -1.19275596121079 0.115690994452218 no 2984 0.11648248098367 4307 17217662 SGTC_2647 atorvastatin 60.16 µM -1.19481498538511 0.115286331337767 no 2985 0.116079662071491 4241 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_669 0108-0021 26.2 µM -1.19529966513061 0.115191222965045 no 2986 0.115984985287215 4262 17201 SGTC_1800 st050079 29.0735 µM -1.19656565232237 0.114943062345134 no 2987 0.115737947448274 4128 3645560 SGTC_727 3032-0951 202 µM -1.19675432717177 0.11490611061379 no 2988 0.115701162488425 4325 3652836 SGTC_1026 k007-1105 30.6 µM -1.19780871139937 0.11469976634008 no 2989 0.115495747519117 4257 7066794 SGTC_830 4076-0286 57.8 µM -1.20089048760086 0.114098170945541 no 2990 0.114896842327436 4356 6866659 SGTC_3125 9127534 49.47 µM -1.20096171952797 0.114084292344259 no 2991 0.114883025450019 4168 1639235 SGTC_1162 k048-0130 20.1 µM -1.20116938775988 0.114043837792397 no 2992 0.11484275072897 4243 6797406 SGTC_102 gallobenzophenone 83.616 µM -1.20321116547437 0.113646635927249 no 2993 0.114447307612661 4275 70837 SGTC_1996 st072960 66.8 µM -1.20485346459653 0.113327863952868 no 2994 0.114129938004084 4313 1719405 SGTC_2420 aureobasidin a 50 nM -1.20493919703704 0.113311240730275 no 2995 0.114113387688459 4385 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1900 st060200 72.8 µM -1.2051295772843 0.113274332881034 no 2996 0.114076641632321 4283 688945 SGTC_565 1418-0001 44.5 µM -1.20607384190009 0.113091400851122 no 2997 0.113894509908461 4348 2862145 SGTC_1967 st070177 51.4 µM -1.20721480007811 0.112870644831881 no 2998 0.113674716087774 4327 5729214 SGTC_70 0141-0289 43.283 µM -1.21103475692069 0.112133787636881 no 2999 0.112941042089088 4248 352408 SGTC_2596 sinensetin 100 µM -1.2111033602532 0.112120585783734 no 3000 0.112927896865768 4309 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_297 0986-0032 24 µM -1.2138980647102 0.111583724093779 no 3001 0.112393326018147 4251 2847425 SGTC_2746 daunorubicin 9.88 µM -1.21390373831708 0.111582636070048 no 3002 0.112392242613191 4272 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2614 arthonioic acid 13.39 µM -1.21428692026257 0.111509171096814 no 3003 0.112319089282026 4147 6710684 SGTC_1770 st043884 66.3 µM -1.21893583592182 0.110620621146709 no 3004 0.11143427342133 4305 670149 SGTC_1587 estradiol valerate 56.1 µM -1.2212201127262 0.110185890131842 no 3005 0.111001345523012 4351 13791 A steroid. SGTC_477 mead ethanolamide 10 µM -1.22185152119961 0.110065940409464 no 3006 0.11088189053931 4235 16061185 SGTC_2104 5389443 200 µM -1.22196142487436 0.110045071400689 no 3007 0.110861107483073 4323 2244536 SGTC_2078 5212016 200 µM -1.22771688533657 0.108956162578828 no 3008 0.109776632775727 4196 1899708 SGTC_1049 3226-0134 66 µM -1.22806307653093 0.108890912500028 no 3009 0.109711645221769 4340 5702385 SGTC_1337 1486-1011 40.3 µM -1.23166590976421 0.108213517881792 no 3010 0.109036954610295 4285 X1337 SGTC_1495 4469-0029 237 µM -1.23417255237641 0.10774401861101 no 3011 0.108569306449588 4325 793680 SGTC_746 1095-0025 46.6 µM -1.23496498460599 0.107595900158588 no 3012 0.108421768054763 4330 6749286 SGTC_1291 0993-0025 5.79 µM -1.23605665033669 0.107392090478117 no 3013 0.108218753432983 4313 4353356 SGTC_1381 2324-0066 62.1 µM -1.24507434802482 0.105719158848394 no 3014 0.106552211183827 4351 10885928 SGTC_1574 spiramycin 23.7 µM -1.24907083595882 0.104983800327157 no 3015 0.105819583198706 4283 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3185 9108267 49.47 µM -1.25014437940127 0.104786899454051 no 3016 0.105623405280836 4332 4910486 SGTC_84 0443-0269 128.823 µM -1.25079223759625 0.104668203873417 no 3017 0.105505143834687 4250 6150058 SGTC_698 k064-0052 127 µM -1.25196529089888 0.104453533947063 no 3018 0.105291255862745 4413 5088751 SGTC_109 0132-0036 33.701 µM -1.25492573171424 0.103913189164354 no 3019 0.104752860960046 4173 67274 A color developer. SGTC_873 0591-4978 488 µM -1.25678360269401 0.103575124305537 no 3020 0.104416002597167 4383 3305145 SGTC_2257 7960413 200 µM -1.25687524335563 0.103558469721724 no 3021 0.104399407182289 4357 2974689 YIL048W NEO1 SGTC_3111 9122088 49.47 µM -1.25740744772887 0.103461786418002 no 3022 0.104303066867554 4212 16876704 SGTC_15 0266-0086 27.098 µM -1.25776305658926 0.10339722099358 no 3023 0.104238730017892 4396 1712902 YIL048W NEO1 SGTC_2460 5552655 174.22 µM -1.26259372420414 0.102523046006739 no 3024 0.103367612221522 4356 5401989 SGTC_839 0122-0028 230 µM -1.26308432793401 0.10243456605996 no 3025 0.10327943779217 4354 759448 SGTC_916 4466-0038 42 nM -1.2668059998503 0.101765173506253 no 3026 0.102612333118628 4397 5722064 YGL116W CDC20 SGTC_3000 9075062 71.4286 µM -1.26848003365 0.101465116646968 no 3027 0.102313288266119 4310 17057871 SGTC_685 1278-0033 54.9 µM -1.26881384444595 0.101405360932394 no 3028 0.102253733085095 4417 3590572 SGTC_155 k072-0202 43.6 µM -1.26986806216551 0.101216812974668 no 3029 0.102065815678431 4337 5857737 SGTC_2991 9074669 71.4286 µM -1.27049758652281 0.101104343765496 no 3030 0.101953721004282 4323 17333109 SGTC_290 2043-6722 48.1 µM -1.27134125597079 0.10095375880975 no 3031 0.101803635649227 4356 773758 YLR208W SEC13 SGTC_3080 9117754 49.47 µM -1.27171905623363 0.100886378987837 no 3032 0.101736478683441 4336 9550191 SGTC_1688 st021091 57.6 µM -1.27225832419508 0.100790258580003 no 3033 0.101640675448392 4364 3656366 SGTC_2602 kawain 100 µM -1.27233261692837 0.100777021701663 no 3034 0.101627482179997 4330 5369129 SGTC_2918 7977171 22.06 µM -1.27543762922245 0.100224928892503 no 3035 0.101077193497726 4343 2236483 SGTC_147 4466-0538 29.23 µM -1.27715603234747 0.0999203355042085 no 3036 0.100773583047211 4439 6742687 YHR072W ERG7 SGTC_1899 st063254 59.6 µM -1.2781372156209 0.0997467206003822 no 3037 0.100600524439596 4291 3093813 SGTC_2266 7929956 200 µM -1.27871461063561 0.0996446568328278 no 3038 0.100498786356189 4291 2967153 SGTC_2688 kanamycin b 96.69 µM -1.27905137483777 0.09958516363909 no 3039 0.100439482543205 4361 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3176 9106582 49.47 µM -1.28009300685645 0.0994013119144836 no 3040 0.100256213911242 4337 17018027 SGTC_2437 5741531 144.16 µM -1.2819102182409 0.0990811619257359 no 3041 0.0999370715144833 4370 2262990 SGTC_1164 k060-0068 93.7 µM -1.28327878657457 0.0988405506516279 no 3042 0.0996972109798287 4362 5963676 SGTC_1363 1636-0063 10.4 µM -1.28512280073361 0.0985170266390965 no 3043 0.0993746875442418 4360 6072185 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.28528147804939 0.0984892236855826 no 3044 0.0993469701025913 4352 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2567 aureobasidin a 60 nM -1.28536088083105 0.0984753131300963 no 3045 0.0993331023026619 4455 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_96 0929-0093 37.281 µM -1.28709800902133 0.0981713459352819 no 3046 0.0990300646633603 4361 6991579 SGTC_150 3970-0969 77.2 µM -1.28823280013239 0.0979731487586957 no 3047 0.0988324687161782 4421 6615640 SGTC_1754 st042065 16.137 µM -1.28916579371281 0.0978104163490122 no 3048 0.0986702270691647 4120 1126236 YIL048W NEO1 SGTC_346 4513-0042 7.16 µM -1.2895142569382 0.0977496883649933 no 3049 0.0986096815586725 4314 2827372 SGTC_1446 4239-0190 62 µM -1.29348099284981 0.0970603378947565 no 3050 0.0979223768739957 4381 1340085 SGTC_1907 st060210 83.7 µM -1.29919959382508 0.0960728333398252 no 3051 0.0969377204367166 4371 688793 SGTC_1762 st045503 25.4615 µM -1.30580492594333 0.0949414230078605 no 3052 0.0958094522442817 4425 4645554 SGTC_2351 9026858 72.31 µM -1.30684835432404 0.0947635983494847 no 3053 0.0956321095575655 4265 1409300 SGTC_2008 4012253 172 µM -1.3070024476573 0.0947373580469921 no 3054 0.0956059401011631 4362 603940 SGTC_1610 st001799 48.1 µM -1.3119841539809 0.0938919139589975 no 3055 0.0947627405883033 4323 621897 SGTC_2935 9038016 29.96 µM -1.31260410483956 0.0937870931003151 no 3056 0.0946581928542834 4339 6463195 SGTC_1771 st048882 4.1505 µM -1.31642674873016 0.0931426710488543 no 3057 0.0940154247025121 4408 4580403 SGTC_1316 1272-0050 65.9 µM -1.31672931294761 0.0930918048119623 no 3058 0.0939646871580758 4350 7340392 SGTC_3007 9078383 71.4286 µM -1.31848777397291 0.0927965836872244 no 3059 0.0936702075633601 4375 6496995 SGTC_1432 4049-0298 68.4 µM -1.32017483715213 0.092514000532844 no 3060 0.0933883255643364 4398 741646 SGTC_2063 5246145 200 µM -1.32023877888981 0.0925033028248493 no 3061 0.0933776542335584 4427 711240 SGTC_2390 9097792 176.6 µM -1.32103048305761 0.0923709233665083 no 3062 0.0932456001756327 4421 4497149 SGTC_542 3381-0244 89.3 µM -1.32385871240803 0.091899165041301 no 3063 0.0927749862896019 4403 1112843 SGTC_2056 5235370 200 µM -1.32840968154388 0.0911437974301039 no 3064 0.0920214014140735 4298 5511916 SGTC_638 3970-0837 4.09 µM -1.33021662798322 0.0908451617743636 no 3065 0.0917234535587857 4369 4118451 YLR208W SEC13 SGTC_3236 9132701 49.47 µM -1.3305814443122 0.0907849564404163 no 3066 0.0916633857126677 4383 24282524 SGTC_1979 st071809 45.3 µM -1.33111724511306 0.0906965873642375 no 3067 0.0915752177256031 4433 4976333 SGTC_391 gliotoxin 8.33 µM -1.33465600460457 0.0901145460378579 no 3068 0.0909944795486359 4459 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_954 1189-0853 2.85 µM -1.33609692257785 0.0898783461360238 no 3069 0.0907587978745979 4311 2828194 SGTC_3259 9138485 49.47 µM -1.33661438775737 0.0897936339726486 no 3070 0.0906742700729415 4397 17646153 SGTC_425 3825-7017 13.1 µM -1.34009979896759 0.0892245968069027 no 3071 0.0901064507224868 4415 3397440 SGTC_2349 9023730 187.07 µM -1.3422838301717 0.0888693963155216 no 3072 0.0897519921390653 4433 4126287 SGTC_3174 9107204 49.47 µM -1.34321872273793 0.0887176720108872 no 3073 0.0896005804384087 4418 3938802 SGTC_553 k007-0256 45.7 µM -1.34354734816392 0.0886643850320218 no 3074 0.0895474026360814 4456 6287000 SGTC_2736 butenafine 14.65 µM -1.34786109607945 0.0879671147464215 no 3075 0.0888515314539771 4340 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3314 9135860 59.4275 µM -1.34852883279799 0.0878595488627152 no 3076 0.0887441765062611 4385 25252478 SGTC_2419 paclitaxel 166.5 µM -1.35263929711032 0.0871995528895341 no 3077 0.0880854458987117 4351 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2847 9005661 71.43 µM -1.35273379612042 0.0871844233251468 no 3078 0.0880703447565671 4443 2991449 SGTC_956 1185-0240 191 µM -1.35732584986763 0.0864515820829526 no 3079 0.0873388486241305 4384 1416193 SGTC_1668 st014914 51.6 µM -1.35981579248596 0.0860561453078034 no 3080 0.0869441117934039 4415 2839556 SGTC_581 0958-0271 211 µM -1.36050248306192 0.0859473279364442 no 3081 0.0868354838331418 4417 4591145 SGTC_671 0560-0003 407 µM -1.36157864336251 0.0857769998858906 no 3082 0.0866654494775344 4334 3238678 SGTC_3341 9147222 25.867 µM -1.3619589583775 0.0857168664229975 no 3083 0.0866054188894002 4410 1939759 SGTC_2612 dictamnine 15.46 µM -1.36341998773028 0.0854861494215986 no 3084 0.0863750926478384 4336 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_356 1634-0012 32.5 µM -1.36372993300421 0.085437264573242 no 3085 0.086326289789672 4409 735457 SGTC_398 bronopol 33.3 µM -1.36479375052045 0.0852696375708745 no 3086 0.0861589417909633 4337 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2462 5162487 171.77 µM -1.36522747484655 0.0852013658609673 no 3087 0.0860907827626703 4368 2259986 SGTC_3230 9131665 49.47 µM -1.36528008818055 0.0851930868838698 no 3088 0.0860825174124141 4417 15943720 SGTC_2192 5915882 198.485 µM -1.36591161383632 0.0850937601296267 no 3089 0.085983353512619 4378 2876149 SGTC_1451 4152-0210 104 µM -1.36987703335959 0.0844720589744016 no 3090 0.0853626450344428 4448 659563 SGTC_1579 chlormadinone acetate 49.4 µM -1.37050393938945 0.0843740849780234 no 3091 0.0852648232640454 4452 45114258 A steroidal progestin. SGTC_1022 4477-0945 21.3 µM -1.37273929373204 0.0840254338295992 no 3092 0.0849167044790216 4363 4648966 SGTC_2775 cyproheptadine 69.59 µM -1.37306065026525 0.0839754004907333 no 3093 0.0848667463364544 4421 2913 A selective serotonin reuptake inhibitor. SGTC_3077 9117319 49.47 µM -1.37508106767554 0.0836613456298464 no 3094 0.0845531565676635 4383 17154678 SGTC_2644 guaiazulene 100 µM -1.37762627593472 0.0832669739795033 no 3095 0.0841593520060925 4449 3515 A coloring agent. SGTC_1447 4239-0816 81.9 µM -1.37953588531487 0.0829720051787159 no 3096 0.0838647949589478 4427 1341554 SGTC_357 1325-0123 420 µM -1.38114725802221 0.0827237156773495 no 3097 0.0836168437855131 4439 1098503 SGTC_1805 st050013 60.3 µM -1.38641225083619 0.0819163532181698 no 3098 0.082810528871187 4367 4037144 SGTC_573 3702-0553 84.7 µM -1.38719189487797 0.0817973048708953 no 3099 0.0826916281398693 4370 1222756 SGTC_2247 cerulenin 830 nM -1.38732321842416 0.081777265160092 no 3100 0.0826716131036981 4452 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2605 digitonin 300 nM -1.38799187223157 0.0816752873121135 no 3101 0.0825697600422147 4430 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3214 9129694 49.47 µM -1.38852668212679 0.0815937913204625 no 3102 0.0824883628388908 4448 17158655 SGTC_3225 9130819 49.47 µM -1.39208519133093 0.0810530951899404 no 3103 0.0819483010086502 4386 4547121 SGTC_353 1988-1175 58.3 µM -1.40075805271059 0.0797466327869802 no 3104 0.0806432181401403 4251 2788357 SGTC_1606 st000094 49.2 µM -1.40718945739239 0.0787881508553597 no 3105 0.079685608482969 4457 1242210 SGTC_427 1354-0053 47.3 µM -1.40733704992396 0.0787662578249727 no 3106 0.0796637339770171 4472 6813657 SGTC_3072 9116419 49.47 µM -1.40766330829146 0.0787178788856838 no 3107 0.0796153957498743 4457 17170162 SGTC_2313 7726885 200 µM -1.40792871298482 0.0786785401925582 no 3108 0.079576089934896 4452 726423 SGTC_1096 rimcazole 32.2 µM -1.40916517540173 0.0784954661877221 no 3109 0.0793931662626571 4378 18528119 A dopamine reuptake inhibitor. SGTC_2241 6772625 37.8075 µM -1.41097651874877 0.0782278570394694 no 3110 0.079125768917922 4240 2285411 SGTC_978 1416-0512 87.4 µM -1.41307570844843 0.0779185875427865 no 3111 0.0788167323945681 4485 6814003 SGTC_2057 5236571 38.335 µM -1.41539401252485 0.077578115464754 no 3112 0.0784765020860635 4386 54684039 YBR257W POP4 SGTC_98 0074-0023 107.663 µM -1.42412782497802 0.0763055842076429 no 3113 0.0772047365213135 4445 3563821 SGTC_443 clozapine 122 µM -1.42414329550419 0.0763033443047733 no 3114 0.0772024977726082 4438 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.4246883624502 0.076224458622982 no 3115 0.0771236523013827 4459 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1270 0831-1170 17.3 µM -1.42556936262385 0.0760970857320235 no 3116 0.076996342539619 4456 6764716 SGTC_1044 1222-0021 1.78 µM -1.43661176962012 0.0745143144653879 no 3117 0.0754141687317565 4380 4306703 SGTC_1333 1482-0047 286 µM -1.44069832976639 0.0739349782029681 no 3118 0.0748349634904344 4483 3811116 SGTC_188 3229-0966 278.469 µM -1.44177047099678 0.0737835562014564 no 3119 0.0746835678875299 4514 5722370 SGTC_1169 aniline yellow 25.8 µM -1.44178316653418 0.0737817645903824 no 3120 0.0746817765692549 4396 6051 A DNA damaging agent. SGTC_1324 1418-0026 34.4 µM -1.44224926419848 0.0737160112870499 no 3121 0.0746160336951799 4498 1372513 SGTC_416 estradiol valerate 100 µM -1.44994312086692 0.0726370857269129 no 3122 0.0735371906264377 4464 13791 A steroid. SGTC_1444 4112-3581 28 µM -1.45784275220374 0.0715419300714392 no 3123 0.072441945585872 4551 2877249 SGTC_245 methotrexate 289.6 µM -1.46119248734606 0.0710813870608659 no 3124 0.0719813120869258 4428 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2291 7917025 104.35 µM -1.47143577510244 0.0696871953971927 no 3125 0.0705866522137014 4376 2964612 SGTC_249 wiskostatin 11.211 µM -1.47255069431675 0.0695367254249474 no 3126 0.070436114037657 4438 2775510 A n-wasp and actin depolymerizer. SGTC_3131 9127911 49.47 µM -1.47514098509428 0.069188104588614 no 3127 0.0700873218016582 4474 45595681 SGTC_261 5-fluorouridine 15.376 µM -1.47544112005879 0.0691477973785822 no 3128 0.0700469935651454 4500 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3014 9081533 49.47 µM -1.47605519259481 0.0690653856945099 no 3129 0.0699645381081051 4501 21367265 SGTC_654 1124-0271 80.9 µM -1.47934876511997 0.0686246625171561 no 3130 0.0695235629420165 4473 5403748 SGTC_2866 9034245 58.44 µM -1.48034905395943 0.0684912410726546 no 3131 0.0693900592416423 4485 6462273 SGTC_2629 bisabolol 100 µM -1.48054015447101 0.0684657743109156 no 3132 0.069364576462818 4501 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3082 9117008 49.47 µM -1.48379143900695 0.0680336146691189 no 3133 0.0689321294918022 4506 41448529 SGTC_2716 st080858 38.6235 µM -1.48596749321933 0.0677455527938064 no 3134 0.0686438597309046 4478 5296050 SGTC_3261 9137475 49.47 µM -1.48717197466832 0.0675865114268349 no 3135 0.0684846979502202 4503 17027690 SGTC_846 0335-0850 148 µM -1.48918740243027 0.0673210370300332 no 3136 0.0682190135815391 4468 6819598 SGTC_3011 9081274 71.4286 µM -1.48984140090555 0.0672350650646757 no 3137 0.0681329712044092 4489 6625322 SGTC_834 0312-0008 75.7 µM -1.49051831126315 0.0671461706182134 no 3138 0.0680440027073656 4513 6385573 YIL048W NEO1 SGTC_1228 0124-0032 52.5 µM -1.49216791507613 0.0669299189768449 no 3139 0.06782756562562 4512 X1228 SGTC_2340 7987427 183.45 µM -1.49556485275739 0.0664863013671761 no 3140 0.0673835439877308 4488 2239331 SGTC_2049 5262831 67.185 µM -1.49771687171083 0.0662064419206248 no 3141 0.06710341322626 4440 763417 SGTC_2084 5306078 60.6385 µM -1.50547400634459 0.0652052319706021 no 3142 0.0661011274184458 4441 679340 SGTC_2284 7945075 39.21 µM -1.51307370087767 0.0642357747714066 no 3143 0.0651304695156598 4463 1245402 SGTC_506 n9-isopropylolomoucine 153 µM -1.51492867346085 0.0640008541238249 no 3144 0.0648952340369127 4500 6610355 SGTC_853 0419-0306 21 µM -1.52015155922107 0.0633429962548692 no 3145 0.0642364443781444 4516 762713 SGTC_2717 st081029 62.2815 µM -1.52078913743436 0.0632630507913013 no 3146 0.0641563806110401 4489 5292846 SGTC_2375 9072683 200 µM -1.52087282597406 0.0632525629819352 no 3147 0.0641458771998816 4553 16798029 SGTC_283 0987-0079 11.7 µM -1.52181575942031 0.0631344885288692 no 3148 0.0640276257852265 4506 411556 SGTC_1201 1889-3372 45.9 µM -1.52378940426853 0.0628879037289786 no 3149 0.063780663627266 4414 5392199 SGTC_970 1315-0089 19.5 µM -1.52655257143374 0.0625439383785342 no 3150 0.0634361542045208 4477 6811083 YLR033W RSC58 SGTC_1492 4158-0558 28.5 µM -1.52728824346404 0.0624526079138029 no 3151 0.0633446757989365 4514 3967268 SGTC_1733 st037357 54.9 µM -1.53014144197772 0.0620993792008059 no 3152 0.0629908611043053 4438 1272339 YGL099W LSG1 SGTC_1935 st074532 41.6 µM -1.53021306311619 0.0620905325311132 no 3153 0.0629819994761239 4470 2829742 SGTC_3271 9137798 49.47 µM -1.5388279902958 0.0610335678412444 no 3154 0.061923147319873 4516 6498326 SGTC_1666 st014829 29 µM -1.5427500918948 0.0605570486466619 no 3155 0.0614457114608619 4535 3858230 SGTC_2402 5553605 200 µM -1.54414711166477 0.0603880212411137 no 3156 0.0612763489763169 4552 6758546 SGTC_1250 0485-0349 40.2 µM -1.54616827647236 0.0601441313962145 no 3157 0.0610319664289026 4505 6842794 YDL195W SEC31 SGTC_2417 cerulenin 830 nM -1.54754583510657 0.0599783465904691 no 3158 0.0608658404670096 4519 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1787 fluconazole 80 µM -1.54819160234529 0.059900753860772 no 3159 0.0607880863242194 4182 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2213 7173844 200 µM -1.55308249330445 0.0593156346542074 no 3160 0.0602017139693205 4533 892728 SGTC_1424 4048-1941 275 µM -1.55568728730679 0.059005845535174 no 3161 0.0598912355031695 4591 X1424 SGTC_2319 6033012 152.6 µM -1.55797092319885 0.0587352973348728 no 3162 0.0596200705047243 4476 847246 SGTC_2485 5633444 17.78 µM -1.5597846342852 0.0585211168412189 no 3163 0.0594053919001101 4496 5724239 SGTC_81 0411-0046 9.971 µM -1.56425823879637 0.0579954520894306 no 3164 0.058878467584599 4523 12925265 SGTC_773 4358-1457 44.6 µM -1.56794503582283 0.0575650354790087 no 3165 0.0584469801171663 4519 1186886 SGTC_3204 9114183 49.47 µM -1.57153901294505 0.057147877456455 no 3166 0.0580287499396103 4484 17027248 SGTC_1251 0490-5699 265 µM -1.57328281548475 0.0569463310095019 no 3167 0.0578266733085384 4535 3883818 SGTC_2556 citropten 84.59 µM -1.57393355824635 0.0568712625612139 no 3168 0.0577514053482114 4522 2775 A potential DNA crosslinker. SGTC_2670 beta-carotene 100 µM -1.57566789990272 0.056671572802732 no 3169 0.0575511794629101 4511 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2852 9023854 51.95 µM -1.57754583595303 0.056455973081845 no 3170 0.0573349920499074 4535 19798528 SGTC_3030 9087619 49.47 µM -1.58015741501583 0.0561572213546617 no 3171 0.0570354107042199 4541 25236973 SGTC_2849 9019321 12.99 µM -1.58074199442323 0.0560905194157716 no 3172 0.0569685211054672 4533 16489627 SGTC_2329 6138490 200 µM -1.59535836199778 0.0544429801776142 no 3173 0.0553160607576117 4556 720019 SGTC_1287 0971-0001 34.6 µM -1.60880347548389 0.0529614853420134 no 3174 0.0538296603515078 4541 4665869 SGTC_1977 st070720 65.3 µM -1.60936556014836 0.0529002534251753 no 3175 0.053768215657729 4571 682188 SGTC_2259 7964009 200 µM -1.61053750700154 0.0527727654445984 no 3176 0.0536402820794344 4564 313134 SGTC_503 tyrphostin 8 294 µM -1.61719813853604 0.0520528247381221 no 3177 0.0529177590152773 4565 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2211 7117706 200 µM -1.61882613940728 0.0518780478230673 no 3178 0.0527423381403258 4533 822771 SGTC_2868 9035608 32.47 µM -1.62191270709837 0.0515479643774375 no 3179 0.052411020169527 4551 6462614 SGTC_2543 pimpinellin 60.67 µM -1.62272742247313 0.0514611163186633 no 3180 0.0523238432915935 4428 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_403 arphamenine a 50 µM -1.624063086222 0.0513189873574279 no 3181 0.05218117259554 4553 5487158 An arginine aminopeptidase inhibitor. SGTC_1756 st041558 35.5 µM -1.62573225817565 0.0511418086948384 no 3182 0.0520033123008274 4626 3955792 SGTC_3344 9148862 3.898 µM -1.62695685794494 0.0510121301480388 no 3183 0.0518731304130308 4584 4905352 SGTC_2896 9052656 71.43 µM -1.62933044951058 0.0507615248912802 no 3184 0.0516215417432098 4244 6469436 SGTC_3257 9139206 32.98 µM -1.63036130735685 0.0506529920786636 no 3185 0.0515125786379078 4544 4910041 SGTC_1068 loratadine 26.9 µM -1.63082916707659 0.050603794962062 no 3186 0.0514631855953708 4593 3957 A H1 histamine antagonist. SGTC_675 1309-0189 238 µM -1.63324098877601 0.0503507868505197 no 3187 0.05120916121325 4566 4246530 SGTC_1636 st007707 68.9 µM -1.63354923786755 0.0503185232767241 no 3188 0.0511767669978387 4569 403051 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.63656566595104 0.0500036709292472 no 3189 0.0508606272606147 4582 23665772 A membrane-active detergent. SGTC_2041 5107442 45.335 µM -1.63837728014143 0.0498153324467193 no 3190 0.0506715078100657 4582 793005 SGTC_926 2268-1401 59.4 µM -1.64503650686384 0.0491278863713764 no 3191 0.0499811413998076 4542 2931578 SGTC_1618 st003135 44.5 µM -1.64536811911374 0.0490938523868214 no 3192 0.0499469599698249 4547 1270615 SGTC_3200 9114385 49.47 µM -1.64551326198771 0.0490789620291326 no 3193 0.0499320050171099 4529 17018030 YLR208W SEC13 SGTC_1938 st074717 56.4 µM -1.64694234246045 0.0489325437332036 no 3194 0.0497849487748114 4440 17250979 SGTC_2310 7668677 200 µM -1.64949416707103 0.0486719614239555 no 3195 0.0495232185908974 4536 2197143 SGTC_985 1493-0307 8.71 µM -1.6515677102242 0.0484610372623017 no 3196 0.049311353506614 4601 3278274 SGTC_2107 5363541 170.161 µM -1.65465602397282 0.0481482447773066 no 3197 0.0489971461179468 4513 244052 SGTC_1635 st007035 42.4 µM -1.65567678546965 0.0480452153235554 no 3198 0.0488936454752919 4524 3716403 SGTC_2482 5981709 142.65 µM -1.65600817865548 0.0480118044772898 no 3199 0.0488600812809201 4506 877755 SGTC_2906 7926292 26.41 µM -1.65978681795249 0.04763215791835 no 3200 0.0484786732691655 4561 2966319 SGTC_2886 9058944 51.95 µM -1.67076716504318 0.0465425742648211 no 3201 0.0473838382418156 4546 4949929 SGTC_3289 9119912 71.43 µM -1.67466471201501 0.0461606639447928 no 3202 0.0470000173746588 4567 17014829 SGTC_418 lividomycin a 100 µM -1.69200400389028 0.0444920362215379 no 3203 0.0453226051075389 4604 72394 An antibiotic. SGTC_3298 9116858 71.43 µM -1.69636426035948 0.0440801700713596 no 3204 0.0449084588587501 4634 2506942 SGTC_725 1497-0963 19 µM -1.69685521153648 0.0440339884197846 no 3205 0.0448620187325358 4635 3549977 SGTC_2522 biochanin a 4.94 µM -1.69869076682981 0.0438616711892609 no 3206 0.0446887320241674 4587 5280373 A possible chelator. SGTC_2446 5162541 200 µM -1.70447435742747 0.0433222768738563 no 3207 0.0441462513397254 4557 1549321 SGTC_1662 st014054 52 µM -1.71189151096549 0.0426383844306396 no 3208 0.0434583316940212 4670 2838777 SGTC_2861 9024595 19.48 µM -1.71845006361116 0.0420409545784222 no 3209 0.0428572777085522 4550 16482810 SGTC_122 0236-0016 402.397 µM -1.72943821968265 0.0410552246562411 no 3210 0.0418653473154765 4581 6808838 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.73270240815169 0.0407660376287231 no 3211 0.0415742881415011 4593 6312947 SGTC_3194 9111903 49.47 µM -1.74398923200986 0.0397788097819161 no 3212 0.0405804837503632 4585 17087251 SGTC_452 diindolylmethane 8 µM -1.74738293905258 0.0394858014243683 no 3213 0.0402854674469704 4591 3071 Inhibits expression of several cancer promoting factors. SGTC_167 3672-0051 66.205 µM -1.74742890021319 0.0394818452782369 no 3214 0.040281484012226 4528 3237971 SGTC_3325 9138760 55.175 µM -1.74795754950709 0.0394363645176946 no 3215 0.0402356891943403 4551 43844959 SGTC_2368 9071271 200 µM -1.75562561126837 0.0387814458959876 no 3216 0.0395761780809915 4604 27209959 SGTC_1738 st035555 74 µM -1.75951672093517 0.038452515691066 no 3217 0.0392448913556631 4601 5331140 SGTC_168 3970-0862 530.542 µM -1.76037998131156 0.0383798501032597 no 3218 0.0391717006245394 4529 3135186 SGTC_136 0097-0015 404.482 µM -1.77885611269264 0.0368512632152139 no 3219 0.0376316774393021 4613 4861337 SGTC_1745 st081495 74 µM -1.77997247376044 0.036760521274581 no 3220 0.0375402328146626 4479 13842402 YBL026W LSM2 SGTC_597 k018-0003 82.8 µM -1.78718202000734 0.0361788943870419 no 3221 0.0369540371766068 4660 6786234 SGTC_3251 9135047 49.47 µM -1.78747534027491 0.036155391340725 no 3222 0.0369303471380746 4657 17682963 SGTC_864 0469-0573 172 µM -1.78816679554969 0.0361000361657824 no 3223 0.0368745508192919 4613 689425 SGTC_3313 9133968 57.047 µM -1.79166008768011 0.0358214370810742 no 3224 0.0365937157942266 4609 1494643 SGTC_3107 9121808 49.47 µM -1.79777036218134 0.0353383638012203 no 3225 0.0361067029337499 4578 662681 SGTC_3252 9135871 49.47 µM -1.80174335523565 0.0350271382779989 no 3226 0.0357928967419411 4648 17682838 SGTC_2012 4023501 200 µM -1.80626804511237 0.0346754387906434 no 3227 0.0354382403449268 4604 3477460 SGTC_179 1273-0063 6.77 µM -1.81007528436772 0.0343817575390261 no 3228 0.0351420565905685 4591 3108139 SGTC_2455 5377712 9.75 µM -1.81048955020665 0.0343499257375487 no 3229 0.035109951706871 4616 2243908 SGTC_3264 9137442 49.47 µM -1.81421859417727 0.0340644783301749 no 3230 0.0348220392914769 4590 17015726 SGTC_2186 6124449 200 µM -1.81446203414064 0.0340459117375525 no 3231 0.0348033113530996 4634 3834182 YLR033W RSC58 SGTC_294 k038-0071 157 µM -1.82041595483739 0.0335944046847635 no 3232 0.0343478422692616 4656 24152826 SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.82532390939996 0.0332259330605744 no 3233 0.0339760820957861 4660 165506 SGTC_1491 4138-0063 26.5 µM -1.82881894905488 0.0329655725610699 no 3234 0.0337133676581294 4658 23883227 SGTC_821 1114-0266 29.2 µM -1.8338410585601 0.0325944000201535 no 3235 0.0333387954885586 4655 3123235 SGTC_1482 3346-2049 8.48 µM -1.83536803842795 0.032482230186603 no 3236 0.033225588047995 4661 3826804 SGTC_803 4488-1585 147 µM -1.83956687932315 0.0321754299469125 no 3237 0.0329159253388774 4645 747204 SGTC_695 3505-6186 243 µM -1.84082573078863 0.0320839158465995 no 3238 0.0328235504244685 4625 1819379 SGTC_260 nsc-65238 3.989 µM -1.8414126478877 0.0320413225373029 no 3239 0.0327805553677903 4635 3246252 SGTC_236 1509-0011 5.31 µM -1.84424573366136 0.0318363780869237 no 3240 0.0325736680408225 4641 3107280 SGTC_196 k015-0023 18.111 µM -1.84622045181231 0.0316941690458581 no 3241 0.0324301012694023 4607 5211998 SGTC_1673 st016611 27.3 µM -1.84867472558693 0.0315181568602398 no 3242 0.0322523976758433 4628 5226799 SGTC_2088 5278280 127.392 µM -1.86216316449465 0.030565177858996 no 3243 0.0312900474229788 4664 791502 SGTC_724 3910-0327 137 µM -1.86939479003812 0.0300641591954878 no 3244 0.0307839544465969 4658 2885483 SGTC_2909 7941780 10.49 µM -1.87421315433493 0.0297341299380561 no 3245 0.0304505258879304 4615 1243215 SGTC_3342 9147791 14.508 µM -1.87529419469406 0.0296604994548444 no 3246 0.0303761307885498 4604 1838168 SGTC_2820 7989630 71.43 µM -1.88166076616225 0.0292299308163681 no 3247 0.0299410449734156 4673 2984098 SGTC_1104 tacrolimus 29.8 µM -1.88929073011255 0.0287207715910755 no 3248 0.0294264414917698 4702 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_83 0170-0301 39.027 µM -1.89272082329349 0.0284942908914258 no 3249 0.0291975028535987 4676 3089716 SGTC_1263 0774-1208 64.8 µM -1.90237538254308 0.0278647877840724 no 3250 0.0285610484943498 4634 906585 SGTC_988 1497-1057 103 µM -1.91005985335215 0.0273720586602645 no 3251 0.0280627536610027 4652 3533044 SGTC_2212 7123476 200 µM -1.91758050932264 0.0268968901527186 no 3252 0.0275821117419062 4708 1085715 SGTC_1256 0570-0116 285 µM -1.91822637837201 0.0268564060557243 no 3253 0.0275411564317243 4655 410638 SGTC_1344 1488-0097 29.1 µM -1.92216340219153 0.0266107259665091 no 3254 0.0272926001427124 4684 747966 SGTC_3291 9121177 71.43 µM -1.92712431921346 0.0263038284468739 no 3255 0.0269820693304874 4644 17015612 SGTC_2842 9000675 19.48 µM -1.94445594412379 0.0252547721229754 no 3256 0.0259202465916083 4637 2989072 SGTC_1764 st044502 93.5 µM -1.9555488012122 0.0246019140408171 no 3257 0.0252591645937181 4679 8407 SGTC_1514 1189-1591 158 µM -1.95931715978881 0.0243833791734677 no 3258 0.0250378276881217 4671 767698 YMR146C TIF34 SGTC_2298 7976326 193.81 µM -1.97737406913405 0.0233587099723382 no 3259 0.0239996814208086 4651 2235818 SGTC_2576 guaiol 23.12 µM -1.98342616477221 0.0230234853722018 no 3260 0.0236599234572896 4608 227829 SGTC_2010 4012422 159 µM -1.99615766844976 0.0223315018839639 no 3261 0.0229583817708415 4651 952393 SGTC_788 1182-0090 188 µM -2.01379469576608 0.021401944909371 no 3262 0.0220155464278294 4673 5715185 SGTC_855 0428-0020 25 µM -2.01420697054179 0.0213806133442871 no 3263 0.0219939040816043 4696 6812414 SGTC_2977 9011197 71.43 µM -2.02748031977189 0.0207033790523094 no 3264 0.0213066575557224 4707 2704722 SGTC_2970 9090938 41.86 µM -2.05619080787463 0.0193004587449322 no 3265 0.0198820639791798 4691 17217104 SGTC_2487 5918373 44.05 µM -2.05998135657641 0.0191214166348423 no 3266 0.0197001615742116 4709 2876279 SGTC_3119 9125183 49.47 µM -2.07315617636942 0.0185100631937664 no 3267 0.0190788736731128 4673 22695334 SGTC_1637 st007924 17.4 µM -2.08956556528662 0.0177719612905402 no 3268 0.0183284212483551 4653 683336 SGTC_1962 st076595 64.5 µM -2.09323449034936 0.0176104104938765 no 3269 0.0181641136418037 4676 279619 SGTC_2361 9034121 116 µM -2.11645985808929 0.0166165551974554 no 3270 0.0171528578987441 4718 6496917 SGTC_3090 9117696 49.47 µM -2.14842580778133 0.0153274310618002 no 3271 0.0158399722108207 4710 7923821 SGTC_1421 4029-0249 71.4 µM -2.16005484377789 0.0148802479774681 no 3272 0.0153842120794383 4760 2894095 SGTC_2763 lisinopril 49.32 µM -2.16024402629076 0.0148730668792336 no 3273 0.0153768917823932 4648 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3270 9137563 49.47 µM -2.16099514586849 0.0148445848465365 no 3274 0.0153478571912002 4716 17015724 SGTC_415 dibenzyl ketone 100 µM -2.16441672796562 0.0147154330863923 no 3275 0.0152161905740204 4703 7593 SGTC_1736 st036774 51 µM -2.17638376655287 0.0142712969109331 no 3276 0.0147632883067851 4723 1272247 SGTC_1300 1094-0077 113 µM -2.18864910095938 0.0138281195387652 no 3277 0.0143111770531251 4729 5532636 SGTC_72 0744-0168 198.391 µM -2.19134739692721 0.0137322319366844 no 3278 0.0142133313105741 4643 677577 SGTC_3049 9092223 49.47 µM -2.19426678272021 0.0136291341597151 no 3279 0.0141081179934517 4699 8623917 SGTC_2549 cedrol 20.94 µM -2.19776309753984 0.0135065417775121 no 3280 0.013982996227694 4706 6708665 A sedative which affects the nervous system. SGTC_56 0957-0365 83.25 µM -2.21597703795699 0.0128831820463003 no 3281 0.0133465373861258 4672 6752360 SGTC_1341 1486-1360 280 µM -2.24035252990841 0.0120879795360542 no 3282 0.0125340227386844 4737 3976547 SGTC_2481 5478948 45.16 µM -2.24310823984962 0.0120008150120122 no 3283 0.0124449177287135 4714 77792 SGTC_1053 3366-3204 134 µM -2.24893785562758 0.0118182157477308 no 3284 0.0122582250563815 4729 3632071 YPR165W RHO1 SGTC_660 4031-1742 102 µM -2.25343481229702 0.0116790106997718 no 3285 0.0121158733087621 4643 6738706 SGTC_833 3852-0053 558 µM -2.25693007288071 0.0115717987600525 no 3286 0.0120062222826557 4739 3123681 SGTC_2341 7987486 176.74 µM -2.25969955105992 0.0114874569884153 no 3287 0.0119199520956661 4728 1258686 SGTC_1046 2001-0062 216 µM -2.27115321890667 0.0111442921617463 no 3288 0.0115688521269453 4714 739778 SGTC_2641 levomentholum 100 µM -2.28632428010191 0.010703495392531 no 3289 0.011117647230194 4740 16666 SGTC_1776 st049249 45.9 µM -2.31886408705344 0.0098089612338461 no 3290 0.0102012034682738 4754 1822314 SGTC_840 0245-0196 390 µM -2.32062996820658 0.00976234163899536 no 3291 0.0101534116728149 4774 3827528 SGTC_973 1325-0077 65.9 µM -2.33290224954715 0.00944366518656945 no 3292 0.00982663814648113 4752 2835149 SGTC_986 1493-0483 84 µM -2.33953637612891 0.00927521337919269 no 3293 0.00965384562049774 4727 40079 SGTC_652 0437-0092 114 µM -2.35119714882647 0.00898549241276871 no 3294 0.00935655800656818 4732 3091274 SGTC_1631 benzylvanillin 81.9 µM -2.35605454447236 0.00886716505610622 no 3295 0.00923510270405768 4742 75506 SGTC_2588 indole-3-carbinol 100 µM -2.35917355119643 0.00879190720762973 no 3296 0.00915784387605085 4723 3712 Induces cell cycle arrest. SGTC_3327 9140648 26.9345 µM -2.37784258881077 0.00835304476449037 no 3297 0.00870712903469605 4754 8029710 SGTC_2239 6685329 187.64 µM -2.38095105873863 0.00828187120961761 no 3298 0.00863400298790332 4721 805680 SGTC_2507 purpurin 79.67 µM -2.41739931415644 0.00748623331338202 no 3299 0.00781592900041619 4732 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_977 1348-1378 135 µM -2.45311173036017 0.00677276480572718 no 3300 0.00708131704056554 4744 X977 SGTC_2093 5331342 194.4 µM -2.45785386639563 0.0066826932004917 no 3301 0.00698850176382368 4758 33839 SGTC_1678 st019265 80.2 µM -2.46000538166729 0.006642177875456 no 3302 0.00694674662027252 4739 5367020 SGTC_2038 4100038 30.985 µM -2.46362135990397 0.00657457414221418 no 3303 0.00687706619816169 4737 3596803 SGTC_2957 9076800 11.52 µM -2.46402033165847 0.00656715242930385 no 3304 0.0068694158929498 4721 16459615 SGTC_2536 dehydroabietamide 32.04 µM -2.47459936809445 0.00637304398112094 no 3305 0.00666928546438833 4755 3983547 SGTC_2648 atorvastatin 78.68 µM -2.48941174111586 0.00610979655540711 no 3306 0.00639773418924325 4768 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_118 0083-0097 135.343 µM -2.50029622066177 0.00592254357845371 no 3307 0.00620447500316833 4722 5207356 SGTC_2976 9009005 19.48 µM -2.53065171040958 0.00542692999112736 no 3308 0.00569254186750892 4740 2993148 SGTC_3202 9113761 49.47 µM -2.58103867752624 0.0046852443132715 no 3309 0.00492517725611726 4711 4798415 SGTC_2600 tangeritin 87.95 µM -2.58934927947657 0.00457200832580268 no 3310 0.00480787532829899 4735 68077 A bioactive flavone. SGTC_58 0957-0393 9 µM -2.60209613488586 0.00440306999952525 no 3311 0.00463279375284453 4353 6997992 SGTC_1828 st055811 49 µM -2.60600506463599 0.0043523929208192 no 3312 0.00458025535558699 4777 5877589 SGTC_2561 acetosyringone 100 µM -2.62166588892892 0.00415454711370434 no 3313 0.00437505830899601 4761 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2978 9011784 42.97 µM -2.63350990582001 0.00401030456537426 no 3314 0.00422536852996216 4758 2994934 SGTC_2550 chrysin dimethyl ether 71.87 µM -2.63760729741055 0.00396145837986856 no 3315 0.00417466036674614 4743 88881 An O-methylated flavonoid and antioxidant. SGTC_900 1112-0045 141 µM -2.64165349297598 0.00391374611924499 no 3316 0.00412512070589435 4746 56211 YIL048W NEO1 SGTC_1687 st020778 55.3625 µM -2.64380932708915 0.00388853556993919 no 3317 0.00409894109336948 4796 4259299 SGTC_2659 sanguinarine 24.21 µM -2.65286173680042 0.00378425668664799 no 3318 0.00399062781836951 4763 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_997 3996-0078 137 µM -2.68533922951791 0.00343045524994655 no 3319 0.0036228112016274 4784 735687 SGTC_2754 granisetron 64.02 µM -2.72118698003098 0.0030746878315826 no 3320 0.0032523978503069 4756 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1730 st033808 45.1 µM -2.722451017336 0.0030627727790293 no 3321 0.00323998194110566 4741 1045166 SGTC_3001 9076041 71.4286 µM -2.73815461509754 0.00291817667253856 no 3322 0.00308925103411524 4774 16004211 SGTC_2851 9015922 71.43 µM -2.74445151876037 0.00286194566069755 no 3323 0.00303060533230404 4763 2996893 SGTC_291 SEC14.278 35.5 µM -2.74467230573012 0.00285999189771034 no 3324 0.00302856737143528 4787 1068044 SGTC_2831 7999036 19.48 µM -2.78848063738293 0.0024953072160128 no 3325 0.00264779564476323 4746 2988270 SGTC_3086 9117350 49.47 µM -2.79612769293011 0.00243614309578601 no 3326 0.00258594808094825 4785 2679265 SGTC_1045 1348-1485 165 µM -2.81441970723863 0.00229973563778494 no 3327 0.00244326915446072 4764 6810614 SGTC_3290 9121031 71.43 µM -2.89957552843014 0.00175136107406439 no 3328 0.00186834153685827 4787 17014854 SGTC_3100 9120536 49.47 µM -2.90827404194418 0.00170264478807984 no 3329 0.00181714853960544 4756 16421196 SGTC_2791 5663188 71.43 µM -2.90876759855462 0.0016999179527317 no 3330 0.00181428243901676 4768 54690634 SGTC_1037 k284-1091 78.7 µM -2.91319745967487 0.00167562095774051 no 3331 0.00178874152984101 4752 3334711 SGTC_2101 5377231 179.231 µM -2.94135458794283 0.00152843616354181 no 3332 0.00163390113976817 4788 2844213 SGTC_1050 3232-1156 69.3 µM -2.94875862688539 0.00149174252726543 no 3333 0.0015952652853315 4778 700529 SGTC_2806 7952793 58.44 µM -2.98202838316805 0.00133657807689449 no 3334 0.00143172725227585 4775 2972490 SGTC_1002 4049-0206 172 µM -2.98913668593229 0.00130540116035488 no 3335 0.00139883472901003 4789 4662749 SGTC_3293 9120939 62.045 µM -2.9963288200127 0.00127453453771954 no 3336 0.00136625803357747 4778 934087 SGTC_2418 pentamidine 31.67 µM -3.00548032382751 0.00123622414377899 no 3337 0.0013258087564185 4769 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3052 9092717 49.47 µM -3.0869845823833 0.000938706971094335 yes 3338 0.00101099041813691 4784 25237534 SGTC_1106 tegaserod maleate 11.7 µM -3.178726581495 0.00068338149952075 yes 3339 0.00073961776893766 4801 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_608 k048-0125 159 µM -3.22059220023498 0.000589646532089232 yes 3340 0.000639630180713061 4801 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2753 fluvastatin 17.09 µM -3.23189005885741 0.000566470080752185 yes 3341 0.00061487179926276 4775 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_3095 9117207 49.47 µM -3.23267229371121 0.00056489699380013 yes 3342 0.000613190787374743 4800 17015229 SGTC_2292 7671323 168.05 µM -3.32629625151242 0.000403261443168934 yes 3343 0.000440041677431334 4794 937504 SGTC_2532 xanthone 78.9 µM -3.45452902075516 0.000250713198560775 yes 3344 0.000275627442334885 4798 7020 An insecticide. SGTC_3096 9117468 49.47 µM -3.54455171292474 0.000177899915968268 yes 3345 0.000196640673933147 4804 41316311 SGTC_2584 androsterone 48.74 µM -3.63087167480199 0.000127092812986173 yes 3346 0.00014123280551224 4774 2754130 A steroid. SGTC_3309 9129340 25.759 µM -3.70758159613716 9.36930125585062e-05 yes 3347 0.000104624002555936 4802 17158987 SGTC_2027 5150920 200 µM -3.78147650859513 6.94732290214235e-05 yes 3348 7.79504678787389e-05 4802 786715 SGTC_2299 7976368 114.88 µM -3.95370458714552 3.38974391133311e-05 yes 3349 3.84752039050623e-05 4803 2979718 SGTC_1508 1080-0625 72.9 µM -4.01366748329893 2.62257964195448e-05 yes 3350 2.98912742879942e-05 4779 767111 SGTC_164 4100-3994 89.624 µM -4.42441845954739 4.11589230216124e-06 yes 3351 4.83512095234941e-06 4802 4615967 SGTC_161 4065-0411 162.148 µM -4.52003365175905 2.61199014681925e-06 yes 3352 3.091490118417e-06 4806 1906281 YLR208W SEC13 SGTC_1510 1123-0200 71.5 µM -4.91955403051505 3.54487956576183e-07 yes 3353 4.33708110983908e-07 4810 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1047 2043-3044 82 µM -4.96188715078479 2.84249049527167e-07 yes 3354 3.49057770337804e-07 4807 669592 SGTC_2555 cholic acid 100 µM -5.3060304387932 4.42148895254526e-08 yes 3355 5.60191283844718e-08 4803 6708657 Influences liver metabolism. SGTC_358 0075-0058 9.45 µM -5.53681549561501 1.18888203823703e-08 yes 3356 1.54010366592485e-08 4807 1069125