SGTCid condition conc unit EMG1|YLR186W.score EMG1|YLR186W.strain.pval EMG1|YLR186W.strain.significant EMG1|YLR186W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_227 fluconazole 33.516 µM 6.48938106923026 2.7920279041388e-10 yes 1 4.30948564115116e-11 25 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_112 phenothiazine 287.218 µM 4.29403432605934 2.11383477211839e-05 yes 2 8.77276646987237e-06 4 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2894 9048625 32.47 µM 3.98973012766414 7.15917286243755e-05 yes 3 3.30742570359895e-05 7 4092861 SGTC_2068 5226020 147 µM 3.62853016291258 0.000274201800770899 yes 4 0.000142519725779341 10 1810509 SGTC_7 0192-1582 4.227 µM 3.51332601386851 0.000410886202823505 yes 5 0.000221267065292904 7 252616 SGTC_103 0844-0104 51.839 µM 3.44643601936181 0.00051691481813341 yes 6 0.000284016526527437 60 5375804 SGTC_2079 5212404 121 µM 3.43237678345928 0.000542200955494817 yes 7 0.000299157844199199 4 758462 SGTC_1766 st045414 44.774 µM 3.39274471611084 0.000619768924435949 yes 8 0.000345980465003265 17 253960 SGTC_2962 9082311 13.18 µM 3.37278607486725 0.000662598935256431 yes 9 0.000372058708986855 20 16459453 SGTC_856 0433-0016 11.3 µM 3.2738290325441 0.000918203152682694 yes 10 0.000530503925210524 9 3911780 SGTC_1466 k213-0079 57.5 µM 3.26287657431619 0.000951471554356845 yes 11 0.000551437703510819 21 3657981 SGTC_384 k007-0144 5.16 µM 3.24931949289852 0.000994183870009293 yes 12 0.00057840735192404 23 6824886 SGTC_1204 4049-0315 18.3 µM 3.20765517740908 0.00113670417873528 no 13 0.000669109219347843 16 588402 SGTC_1298 1079-1278 263 µM 3.13252192056533 0.0014418862963627 no 14 0.000866557426782607 11 2840950 SGTC_1747 st037496 66.6 µM 3.11510353390335 0.001522565100879 no 15 0.000919401778646748 20 723305 SGTC_2257 7960413 200 µM 3.03599056892971 0.00194335390096737 no 16 0.00119873431623301 31 2974689 YIL048W NEO1 SGTC_1198 1612-1005 86.7 µM 2.99477903654904 0.00220210611984325 no 17 0.00137321860168323 11 6998509 SGTC_2049 5262831 67.185 µM 2.9835011234236 0.00227816248298644 no 18 0.00142485494802568 23 763417 SGTC_352 k048-0007 5.11 µM 2.93571087420938 0.00262755218546868 no 19 0.00166392168189386 27 6811911 SGTC_1038 k292-0204 154 µM 2.91502112782573 0.00279329589767852 no 20 0.00177832231964754 17 4454212 SGTC_2358 9037157 4 µM 2.90194555371 0.00290284966677204 no 21 0.00185426494530216 27 2388925 SGTC_1473 k844-0725 134 µM 2.86759814580048 0.0032093169327954 no 22 0.00206800249416186 22 54682906 SGTC_674 0498-0004 451 µM 2.79155755744876 0.00399362042013786 no 23 0.00262275136977423 48 4231473 SGTC_1428 4049-0204 61.7 µM 2.77440488346405 0.00419268572626008 no 24 0.00276514015943643 14 X1428 SGTC_531 3788-1495 174 µM 2.7742123828296 0.00419496927836493 no 25 0.00276677699808915 20 2896655 SGTC_3143 9086658 49.47 µM 2.77252236555601 0.00421506502990619 no 26 0.00278118484519318 35 25236626 SGTC_850 0388-0143 75.9 µM 2.77173736832693 0.0042244285683938 no 27 0.00278790015406882 11 67273 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 2.7383574601951 0.00464020742939974 no 28 0.00308734603596874 26 1377 SGTC_1337 1486-1011 40.3 µM 2.7339950460036 0.00469716036556247 no 29 0.0031285492911743 13 X1337 SGTC_2489 cantharidin 73.42 µM 2.72618108077576 0.00480073515293195 no 30 0.00320359184172472 28 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2844 9010103 25.97 µM 2.71703193258897 0.00492459209595834 no 31 0.00329351260588529 23 2480525 SGTC_2152 5568786 200 µM 2.70378705100641 0.00510894004756568 no 32 0.00342771036262095 20 5399883 SGTC_3286 9117135 37.221 µM 2.70300170575709 0.00512006129274751 no 33 0.00343581968633519 26 3438150 SGTC_1029 k015-0030 64.7 µM 2.7010346368731 0.00514801152407288 no 34 0.00345620696723675 21 2208316 SGTC_268 camptothecin 39.6153 µM 2.66534530282047 0.00567925473434337 no 35 0.00384546536820003 72 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1161 k007-0610 110 µM 2.65972879477443 0.00576714940379385 no 36 0.00391017972712503 57 5843850 SGTC_1067 clotrimazole 1.36 µM 2.6537113968357 0.0058626552634942 no 37 0.00398059428162288 43 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1879 gemcitabine 100 µM 2.62108320584538 0.00640534626092854 no 38 0.00438254332183806 14 60750 A nucleoside analog which inhibits DNA replication. SGTC_2464 5717415 7.67 µM 2.61879488395891 0.00644502422264477 no 39 0.00441204940567939 18 5285744 SGTC_2783 7738165 71.43 µM 2.60585500900623 0.00667351081235389 no 40 0.00458226233715163 29 17201110 SGTC_2895 9054447 58.44 µM 2.59381647380569 0.00689248083534268 no 41 0.00474585692674427 7 2697450 SGTC_678 1218-2179 85.9 µM 2.543665797784 0.00787442204368456 no 42 0.00548479917511738 10 6820081 YOR116C RPO31 SGTC_453 enantio-paf c16 10 µM 2.5373680249274 0.00800604251763617 no 43 0.00558447356048875 48 13871343 A lipid and platelet activating factor SGTC_805 3852-0218 479 µM 2.53639927121549 0.00802645973029326 no 44 0.00559994789432237 33 6615355 SGTC_181 1447-1644 8.07 µM 2.48790301330744 0.00910883810984792 no 45 0.00642493852198244 36 534600 SGTC_2051 5263410 176 µM 2.47367474455992 0.00944973975359083 no 46 0.0066865692917115 27 227584 SGTC_454 lyso-paf C-16 6.67 µM 2.4720552135728 0.00948924136550851 no 47 0.00671693832039075 31 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1986 st071812 45 µM 2.46802494243592 0.00958817011946099 no 48 0.00679304262725107 12 11838594 SGTC_472 calcifediol 10 µM 2.45359078268791 0.00994991086061125 no 49 0.00707189166899963 16 5283731 A vitamin D metabolite. SGTC_1469 k284-2957 126 µM 2.42883852499585 0.0105980145055501 no 50 0.00757363844256626 34 23884841 SGTC_3137 9097352 49.47 µM 2.39450224226761 0.0115577969892745 no 51 0.00832147084334798 43 44120435 SGTC_584 0986-0246 15.4 µM 2.37028518064413 0.0122793162140582 no 52 0.00888718476408232 75 53315 YDR232W HEM1 SGTC_614 0462-0418 107 µM 2.3534234005182 0.0128044530201737 no 53 0.0093007199762974 20 5188303 SGTC_625 k213-0058 121 µM 2.35044913019887 0.0128990707640356 no 54 0.00937538524617772 59 3655420 SGTC_288 1315-0019 35.1 µM 2.34702667157626 0.013008693938699 no 55 0.00946195004690692 53 6811474 SGTC_2849 9019321 12.99 µM 2.33852473332856 0.0132845071512843 no 56 0.00968002207995625 32 16489627 SGTC_2088 5278280 127.392 µM 2.33820375968279 0.0132950181388463 no 57 0.00968834028782035 27 791502 SGTC_479 n-linoleoylglycine 10 µM 2.33256365403707 0.0134808913620148 no 58 0.00983552920566025 26 6433346 An anti-infammatory. SGTC_1030 k029-0042 36.7 µM 2.33156276808877 0.0135141095102414 no 59 0.0098618522055338 33 6080581 SGTC_2040 5100729 123 µM 2.31859314590817 0.013950985912781 no 60 0.0102085535534586 35 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2567 aureobasidin a 60 nM 2.31853812622963 0.0139528648629221 no 61 0.0102100466901599 101 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2786 7743617 45.45 µM 2.30360924299656 0.0144708216270317 no 62 0.0106222942647674 27 583674 SGTC_753 1322-0200 289 µM 2.2967070872459 0.0147158333686184 no 63 0.0108177424409741 19 5403907 SGTC_3273 9137859 49.47 µM 2.2939107675227 0.0148161077968886 no 64 0.01089781240225 30 2377234 SGTC_2081 5214970 32.255 µM 2.26559955623422 0.0158648571274892 no 65 0.0117379561432271 27 2063512 SGTC_24 0417-1663 219 µM 2.25332355303042 0.0163390237947671 no 66 0.0121193778716841 28 4329390 SGTC_3126 9127922 49.47 µM 2.24494498406062 0.0166695744611047 no 67 0.0123858323113271 83 45595682 SGTC_134 0269-0018 6.916 µM 2.23846037967584 0.0169293171129432 no 68 0.0125955241782073 59 4378915 SGTC_691 1548-0686 185 µM 2.23501393231464 0.0170687684710704 no 69 0.0127082170449154 65 46495133 SGTC_1940 st075990 51.1 µM 2.2177809202965 0.0177808746765362 no 70 0.013284886828784 36 1084979 SGTC_1554 st069299 38.7 µM 2.21496198210643 0.0178997388854037 no 71 0.0133813370585899 38 24207999 SGTC_2087 5276107 200 µM 2.21487282972931 0.0179035091404612 no 72 0.013384397254445 34 144405 SGTC_455 paf C-16 10 µM 2.21239732760364 0.0180084689791364 no 73 0.0134696116912366 44 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.20281874721074 0.0184195515710145 no 74 0.0138037631390779 44 368090 SGTC_880 0833-0487 87.2 µM 2.19876327583949 0.0185959930378553 no 75 0.0139473795262229 27 76075 SGTC_1474 0330-0125 5.35 µM 2.19648316082172 0.0186958244780903 no 76 0.0140286895708077 26 X1474 SGTC_122 0236-0016 402.397 µM 2.19016285402796 0.0189749373539913 no 77 0.014256214072237 64 6808838 SGTC_474 dl-dihydrosphingosine 5 µM 2.17913962256884 0.0194702197262965 no 78 0.0146606487872811 33 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2138 5575593 77.673 µM 2.13938135286586 0.0213487968867888 no 79 0.0162023979428051 20 762213 SGTC_1118 chelidonine 707.474 nM 2.13019445380147 0.02180403601806 no 80 0.0165777813841417 30 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2517 totarol 10 µM 2.12644885113595 0.021991981112265 no 81 0.0167329519303811 35 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2793 7325131 81.82 µM 2.10003639800747 0.0233564965277173 no 82 0.0178628197087437 43 4176441 SGTC_2142 5622915 118.518 µM 2.09933946971022 0.0233934448762149 no 83 0.0178934932169772 24 5322196 SGTC_401 neomycin 50 µM 2.09874947738719 0.0234247623386009 no 84 0.0179194953140192 34 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_480 am 92016 50 µM 2.08722996404917 0.0240433349064055 no 85 0.0184336760660473 48 2129 K+ channel blocker. SGTC_2254 7938975 95.19 µM 2.08530067576205 0.0241482635615978 no 86 0.0185210080657986 55 2969277 SGTC_1014 4130-3005 69.3 µM 2.08499960088258 0.0241646728389292 no 87 0.0185346683810538 40 743608 SGTC_2475 5812728 15.03 µM 2.07922135495057 0.024481419896378 no 88 0.0187985048641691 61 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2037 5169046 200 µM 2.07900646299102 0.0244932665611295 no 89 0.0188083782174257 43 5718022 SGTC_3304 9125678 46.087 µM 2.07569790092384 0.0246762706966437 no 90 0.0189609501064209 65 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1193 1488-0126 41.5 µM 2.07487054952016 0.0247222122756943 no 91 0.0189992669190502 40 1384710 SGTC_3259 9138485 49.47 µM 2.06794593730164 0.0251095462066517 no 92 0.0193225535455077 38 17646153 SGTC_1107 amlodipine 47 µM 2.06276664780185 0.0254025679787259 no 93 0.0195674021241062 41 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_229 benomyl 22.8748 µM 2.05523499613623 0.0258337830745178 no 94 0.0199281562276166 57 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2996 9066192 71.4286 µM 2.04535146020713 0.0264089298687742 no 95 0.0204101103654788 49 6472854 SGTC_2604 4'-hydroxychalcone 11.32 µM 2.04532663452183 0.0264103878998428 no 96 0.0204113332768338 64 5282362 SGTC_2307 7538926 6.34 µM 2.02910307379073 0.02737770282911 no 97 0.0212238964509977 75 96582 SGTC_1754 st042065 16.137 µM 2.02299194962943 0.0277496532406388 no 98 0.021536988758967 80 1126236 YIL048W NEO1 SGTC_1708 st033234 31.827 µM 2.01795207383095 0.0280595622832591 no 99 0.0217981264634186 49 674664 SGTC_3174 9107204 49.47 µM 2.00491260311398 0.0288747747166474 no 100 0.0224861955601595 39 3938802 SGTC_800 3448-7362 155 µM 1.99724428000256 0.0293633163660623 no 101 0.022899326506478 122 15991913 SGTC_1608 st001473 40.5 µM 1.99017697482892 0.0298196266389354 no 102 0.0232857218871876 71 7292267 SGTC_1459 k035-0031 35.7 µM 1.98425578873016 0.0302064509175832 no 103 0.0236136660515205 43 3877128 YMR208W ERG12 SGTC_281 1672-3440 14.9 µM 1.98247877354379 0.0303233494720615 no 104 0.0237128403944534 40 6833000 SGTC_1366 1683-0113 21.9 µM 1.97896779581939 0.0305554165919342 no 105 0.0239098161070138 41 708623 SGTC_1282 0886-0010 32.4 µM 1.97798858573486 0.0306204017265895 no 106 0.0239649971691947 75 2836211 YNL267W PIK1 SGTC_924 2046-0044 21.3 µM 1.97422953614831 0.0308709344728711 no 107 0.0241778244826005 62 3623589 SGTC_3006 9075424 71.4286 µM 1.96500617045326 0.0314928479406202 no 108 0.0247067616887066 55 7465181 SGTC_2694 st077685 81.9 µM 1.9623770035635 0.0316720125799959 no 109 0.0248593040395587 42 2838096 SGTC_3341 9147222 25.867 µM 1.93923153271903 0.033285885001123 no 110 0.0262365758051706 47 1939759 SGTC_1978 st071761 42 µM 1.93392051387043 0.0336656075317028 no 111 0.0265614507495008 60 5147680 SGTC_1510 1123-0200 71.5 µM 1.92487627645296 0.0343204447471867 no 112 0.0271224192453373 78 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1929 genistein trimethyl ether 50.5 µM 1.92446242686536 0.0343506577560368 no 113 0.0271483230024988 48 136420 SGTC_3169 9102970 49.47 µM 1.92268421294396 0.0344807247438239 no 114 0.0272598603386924 38 17027839 SGTC_3203 9113543 49.47 µM 1.91915430579711 0.0347401177369472 no 115 0.0274824042215323 70 17018012 SGTC_105 0111-0055 734.78 µM 1.90843879642144 0.0355373705610271 no 116 0.0281672632581574 38 5179370 SGTC_1669 st015249 58.4 µM 1.89345250106475 0.0366774754807258 no 117 0.0291488595972674 41 722793 SGTC_2762 leflunomide 42.06 µM 1.89309569806496 0.0367049802392206 no 118 0.0291725720864866 69 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1821 st053465 65.6 µM 1.89223556559873 0.0367713543531119 no 119 0.0292298008343592 43 675086 SGTC_6 0844-0013 19.835 µM 1.88862018789126 0.0370514175517179 no 120 0.0294713699686411 89 1584900 SGTC_1203 3992-3522 103 µM 1.88769176537706 0.0371236179373319 no 121 0.0295336712496496 74 5322312 SGTC_984 1492-0255 2.91 µM 1.88539080341179 0.0373030519191058 no 122 0.0296885473713755 42 1585198 SGTC_3175 9106517 49.47 µM 1.88359185630779 0.0374438306743251 no 123 0.0298101021306875 57 41468073 SGTC_2801 7907800 81.82 µM 1.87520537268071 0.0381058622853358 no 124 0.030382237663083 60 6620925 SGTC_796 1234-0020 70.7 µM 1.87435144983041 0.0381738034769882 no 125 0.0304410002483876 56 46495034 SGTC_113 0099-0221 2.5 µM 1.87376302274115 0.0382206783335521 no 126 0.030481547551357 56 89219 SGTC_2482 5981709 142.65 µM 1.86913522120241 0.0385909733173996 no 127 0.0308020019538594 70 877755 SGTC_3200 9114385 49.47 µM 1.86360269402918 0.0390374911981208 no 128 0.0311887595284336 61 17018030 YLR208W SEC13 SGTC_2098 5376439 882.5 nM 1.86092102131907 0.039255431650877 no 129 0.0313776653547472 50 2844116 SGTC_3063 1327-0034 4 µM 1.859273351662 0.0393898287186242 no 130 0.0314942011187491 59 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_750 4073-0104 132 µM 1.85764165738586 0.0395232914024487 no 131 0.0316099593471495 30 22330957 SGTC_1042 0350-0096 82 µM 1.85336848456029 0.0398745545883528 no 132 0.0319147806376237 63 3122515 SGTC_720 r052-1644 49.9 µM 1.85159500855024 0.0400210809650325 no 133 0.0320420001733715 66 1422863 YOR257W CDC31 SGTC_2140 5586273 200 µM 1.85052129622814 0.0401100045926005 no 134 0.0321192257591604 59 854421 SGTC_2706 st078239 82.5 µM 1.8467152344965 0.0404265121188269 no 135 0.0323942112807917 67 15434492 SGTC_100 0086-0128 49.5915 µM 1.83864526384646 0.0411043102513099 no 136 0.0329836895409794 66 93297 SGTC_1068 loratadine 26.9 µM 1.83743641046957 0.0412066310986687 no 137 0.0330727479218032 57 3957 A H1 histamine antagonist. SGTC_2116 5511452 16.8835 µM 1.8277257012667 0.0420360857514599 no 138 0.0337953644319722 65 870744 SGTC_1934 st074720 32.6 µM 1.82730944392496 0.0420719408844706 no 139 0.0338266280457923 75 17250992 SGTC_459 nigericin 15.3 µM 1.82590210605543 0.0421933480163611 no 140 0.0339325044582825 80 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1955 wogonin 32.4 µM 1.82556569351317 0.0422224113366998 no 141 0.0339578536679454 48 5281703 A flavanone. SGTC_2981 9013952 38.96 µM 1.8194774760811 0.0427511888136676 no 142 0.0344193080502851 61 2996344 SGTC_2607 solasodine 47.35 µM 1.81910509567113 0.0427837039592217 no 143 0.0344476989036285 90 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2814 7977482 42.97 µM 1.81522133341157 0.043124015216882 no 144 0.0347449512582245 91 6456762 SGTC_129 0088-0017 176.636 µM 1.81458308840809 0.0431801494992505 no 145 0.0347940016766108 51 182446 SGTC_1094 duloxetine 25.4 µM 1.80586831494709 0.0439525426626175 no 146 0.035469455698612 57 60834 A selective serotonin reuptake inhibitor. SGTC_2580 diallyl disulphide 81.36 µM 1.80476009514821 0.0440515581961849 no 147 0.0355561156725006 86 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2597 laccaic acid a 100 µM 1.7971259554858 0.0447385379845236 no 148 0.0361578130069583 71 5491415 A textile dye. SGTC_2448 5185112 27.17 µM 1.79219140012406 0.0451871602913178 no 149 0.0365511558807586 62 5718189 SGTC_832 4083-0019 164 µM 1.78751667750735 0.0456154919698928 no 150 0.0369270095310789 112 1990758 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.7828310128857 0.0460480958551231 no 151 0.0373069078688619 81 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2091 4-phenylthiadiazole 200 µM 1.78271922351837 0.0460584569190142 no 152 0.0373160102346706 64 270010 SGTC_1889 st059080 5.18 µM 1.78050723211259 0.0462638581012464 no 153 0.0374964934061531 56 176925 Isolated from Daphnopsis sellowiana. SGTC_972 1319-0219 195 µM 1.77681541485315 0.0466083106487369 no 154 0.0377993074019419 88 23903702 SGTC_2546 rhodinyl acetate 100 µM 1.7714020680445 0.0471171026624611 no 155 0.0382469324742935 77 6708682 SGTC_689 0833-0039 98 µM 1.76909486343338 0.0473353021778244 no 156 0.0384390224854939 57 5374726 SGTC_1716 st033144 30.6155 µM 1.76755930702998 0.0474809728088738 no 157 0.038567303002834 70 674617 SGTC_868 0527-0199 213 µM 1.76543018567626 0.0476835459875408 no 158 0.0387457469778466 62 2849450 SGTC_3224 9130643 49.47 µM 1.76399717404461 0.0478202777564617 no 159 0.0388662274889829 69 17644395 SGTC_755 1995-0008 37.3 µM 1.75901526599521 0.0482980741197821 no 160 0.0392874578243672 42 689533 SGTC_812 4251-0442 148 µM 1.75697350131711 0.0484949921774929 no 161 0.0394611629974708 76 5723007 SGTC_830 4076-0286 57.8 µM 1.74847947315379 0.0493210993131362 no 162 0.0401905184867333 71 6866659 SGTC_893 0958-0369 48.9 µM 1.74752692146411 0.0494144385338228 no 163 0.0402729896196865 66 6819948 SGTC_2428 5615643 7.78 µM 1.74701967465058 0.0494642004544775 no 164 0.0403169626806944 95 2253075 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.74054305528331 0.0501030918584252 no 165 0.0408818533799708 112 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1302 1159-0335 255 µM 1.73095343414741 0.0510611313013416 no 166 0.0417300350579034 63 649284 SGTC_1122 capsaicin 818.572 nM 1.7213763853365 0.0520324090491509 no 167 0.0425912732832519 66 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3274 9138298 49.47 µM 1.72111911452321 0.0520587017921237 no 168 0.0426146057040084 83 17015756 SGTC_1575 cyproterone acetate 48 µM 1.71880314579166 0.0522958662229401 no 169 0.0428251112705941 75 9880 An androgen receptor antagonist and liver toxin. SGTC_1775 st081588 35.1725 µM 1.71519318411069 0.0526672507153804 no 170 0.0431549070497819 80 1426443 YGL099W LSG1 SGTC_1208 2323-2347 50.3 µM 1.71515456768916 0.0526712347675711 no 171 0.0431584459937507 60 5412760 SGTC_757 1066-0008 322 µM 1.71151655986088 0.0530476414076856 no 172 0.043492898427363 75 6842497 SGTC_568 1193-0097 7.48 µM 1.70861817515843 0.0533490469521156 no 173 0.0437608498757299 104 3646150 SGTC_752 1896-0090 130 µM 1.70365146153144 0.0538686938553803 no 174 0.0442231106045662 77 772567 SGTC_1750 st081859 2.357 µM 1.70303968277603 0.0539329780546866 no 175 0.04428032120101 107 5291695 SGTC_878 0828-0289 13.7 µM 1.70292516336037 0.0539450182176226 no 176 0.0442910371295042 88 745350 YLR208W SEC13 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.70284356475793 0.0539535985018991 no 177 0.0442986738329473 80 1609 A potent and irreversible inhibitor of serine proteases. SGTC_302 1094-0063 18.9 µM 1.69545242365416 0.0547352856978011 no 178 0.0449948141347067 106 5440289 SGTC_1502 4534-4282 27.7 µM 1.68890485734896 0.0554352105721518 no 179 0.0456188321401913 66 3278949 SGTC_3077 9117319 49.47 µM 1.68835006346079 0.0554948404832824 no 180 0.0456720251403974 77 17154678 SGTC_1433 4060-0023 7.6 µM 1.68647645371631 0.0556965926386382 no 181 0.045852033299488 81 3840627 SGTC_36 0335-0881 14.2 µM 1.68605036837148 0.0557425546198643 no 182 0.0458930491668722 121 23828853 SGTC_40 0327-0103 19.753 µM 1.68160130517231 0.056224266490098 no 183 0.0463230886785599 69 409036 SGTC_904 1141-0088 396 µM 1.681302674755 0.0562567171779416 no 184 0.0463520693128161 68 1378119 SGTC_879 0831-1030 162 µM 1.67555874360432 0.0568837595412051 no 185 0.0469123278027447 108 1549252 SGTC_2812 7970281 58.44 µM 1.67331688330007 0.0571299827944658 no 186 0.0471324652567344 90 2233435 SGTC_1545 lovastatin 49.4 µM 1.67181716260708 0.0572951647266501 no 187 0.0472801907205848 98 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1184 1269-1718 139 µM 1.66835108450429 0.0576783627829361 no 188 0.0476230262672958 78 5403821 SGTC_1819 st053448 58.6 µM 1.66621051330169 0.0579160220326189 no 189 0.0478357463562059 89 2857616 SGTC_1295 1013-0063 9.78 µM 1.66591374338566 0.057949031904315 no 190 0.0478652979332364 79 6826038 SGTC_3179 9107801 49.47 µM 1.65826227769719 0.0588052246635405 no 191 0.0486322696998965 52 4818259 SGTC_1319 1306-0155 43.7 µM 1.65802378429462 0.0588320705697088 no 192 0.048656332906166 93 3122360 SGTC_709 3807-1509 243 µM 1.65358732537966 0.0593332141230698 no 193 0.049105694849537 97 1886677 YPL242C IQG1 SGTC_2255 7941087 197.44 µM 1.6491579549295 0.0598368897694588 no 194 0.0495576395474669 81 935561 SGTC_108 0509-0257 621.132 µM 1.64859254749948 0.0599014241131366 no 195 0.0496155682668747 94 536624 SGTC_1374 2889-5571 141 µM 1.64708099431274 0.0600742171125706 no 196 0.049770699530398 126 2853281 SGTC_2892 9047358 58.44 µM 1.6455664595881 0.0602477421409746 no 197 0.0499265246393094 72 6466771 SGTC_2047 4141938 200 µM 1.64410398996277 0.0604156740119115 no 198 0.050077361969156 74 3807862 SGTC_3108 9121785 49.47 µM 1.64063515148513 0.0608154571269893 no 199 0.0504365868130754 85 17140271 SGTC_1425 4048-4433 7.33 µM 1.63348735018565 0.061645760744835 no 200 0.0511832695297019 85 23734946 SGTC_1327 1436-0082 2.18 µM 1.63212801974655 0.0618046605028832 no 201 0.0513262600963132 83 15992205 SGTC_2961 9083290 32.55 µM 1.62498869822964 0.0626444707452661 no 202 0.0520824834973176 68 17741490 SGTC_1476 4112-3294 3.34 µM 1.61477681369081 0.0638611389691788 no 203 0.0531795180131575 73 704369 SGTC_2931 9014674 55.67 µM 1.60495723304179 0.0650483237632489 no 204 0.054251608386721 74 2996810 SGTC_251 melphalan 456.522 µM 1.60468627554326 0.0650813236673274 no 205 0.0542814318969602 103 460612 A DNA alkylator. SGTC_624 k048-0052 28 µM 1.60160467178506 0.0654575468257504 no 206 0.0546215285409809 75 6835531 SGTC_322 k048-0136 19.3 µM 1.60025901379069 0.0656223620796989 no 207 0.0547705676263779 99 6823282 SGTC_573 3702-0553 84.7 µM 1.59944800749375 0.0657218488500317 no 208 0.0548605462116214 91 1222756 SGTC_2465 5809242 33.21 µM 1.59907110013415 0.0657681241451063 no 209 0.054902402637998 85 2731748 SGTC_1055 3448-0672 86 µM 1.59861249617068 0.0658244639043888 no 210 0.0549533656923434 78 748378 SGTC_2364 9055074 200 µM 1.59290629523637 0.066528606112449 no 211 0.0555906069256449 70 6470630 SGTC_1975 st070967 30.8 µM 1.59156530640973 0.0666949265618577 no 212 0.0557412053285225 120 261391 SGTC_1080 nisoldipine 24.4 µM 1.58968872227027 0.066928215933422 no 213 0.0559524935115609 92 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2452 5863136 48.41 µM 1.58690840627952 0.0672750133849105 no 214 0.0562666953756338 81 2184096 SGTC_2622 2-methoxyxanthone 59.94 µM 1.58323850813824 0.0677348962497756 no 215 0.0566835562657979 83 71034 A hepatoprotective. SGTC_550 4123-0385 25.7 µM 1.57690510636747 0.068534255268132 no 216 0.0574086807086538 81 5731123 SGTC_1564 D-Arginine 115 µM 1.57061670379807 0.0693351147569163 no 217 0.0581358538156952 109 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_342 k048-0088 23.3 µM 1.56673914783988 0.0698325220545502 no 218 0.0585878381365712 102 6820570 SGTC_2203 7227154 166.4 µM 1.56576373492837 0.0699580778994333 no 219 0.0587019695593644 59 896304 SGTC_667 1498-1044 59 µM 1.55958405130272 0.0707575710701336 no 220 0.0594291039151518 86 6739982 SGTC_3156 9099931 49.47 µM 1.55408373895636 0.0714750595593013 no 221 0.060082221729301 78 18111053 SGTC_2234 tolnaftate 200 µM 1.55251148829686 0.071681174525937 no 222 0.0602699430050538 60 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_948 3448-0295 75.3 µM 1.55235446949205 0.0717017839995654 no 223 0.0602887156915082 92 678569 SGTC_2290 7904846 200 µM 1.53638033146494 0.0738223121289535 no 224 0.0622225638846419 100 2962154 SGTC_1518 st038567 90.8 µM 1.53452263090666 0.0740719964351978 no 225 0.0624505650589457 87 77966 SGTC_1108 betulinic acid 729.144 nM 1.5317151100426 0.0744505649183416 no 226 0.0627963760277889 83 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_600 1495-0418 41.6 µM 1.53079165875012 0.0745754061594317 no 227 0.0629104458922594 108 5377768 SGTC_324 1315-0088 19.6 µM 1.5278176741145 0.0749785446852894 no 228 0.0632789064014648 102 6787421 SGTC_1199 1638-0010 4.46 µM 1.52688732023612 0.0751049995434405 no 229 0.0633945165471349 99 3111136 SGTC_2283 7944793 200 µM 1.52576117449917 0.0752582841721427 no 230 0.0635346765870875 90 2970533 SGTC_3023 9089636 49.47 µM 1.52564982240065 0.0752734537418244 no 231 0.0635485485545325 83 17249241 SGTC_2945 9067681 61.76 µM 1.5208756879685 0.0759260319209168 no 232 0.06414551802614 118 16456930 SGTC_213 1246-0773 967 nM 1.52086403542296 0.0759276299651373 no 233 0.0641469804036693 75 6251622 SGTC_353 1988-1175 58.3 µM 1.51958751019811 0.0761028493138299 no 234 0.0643073394519862 108 2788357 SGTC_3276 9139060 49.47 µM 1.51926911258168 0.0761466013685347 no 235 0.0643473855501023 119 4870619 SGTC_1690 st023502 41.2 µM 1.51641318886273 0.0765398996260013 no 236 0.0647074530971497 94 24207482 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.51620781743471 0.0765682414157982 no 237 0.0647334059848248 86 6710655 SGTC_2293 7624732 200 µM 1.50935384049008 0.0775186932901068 no 238 0.0656041912509451 100 894453 SGTC_1711 st032263 62.8 µM 1.5092497647189 0.0775331943836914 no 239 0.0656174835480794 85 3958979 SGTC_371 0195-0006 7.36 µM 1.50698918282363 0.0778486744573883 no 240 0.0659067149595639 99 3928593 SGTC_2871 9038510 12.99 µM 1.50689502491911 0.0778618359570572 no 241 0.0659187834435248 120 4945164 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.50621790110416 0.077956534841559 no 242 0.0660056227576459 111 688803 SGTC_2818 7996756 12.99 µM 1.50243017089222 0.0784878788065095 no 243 0.0664930246623912 96 2241621 SGTC_380 3970-0968 6 µM 1.49739002512791 0.079199163456053 no 244 0.0671459011208554 91 2891601 SGTC_3059 1327-0034 3 µM 1.4955704372415 0.0794571461916108 no 245 0.067382815881097 95 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_533 1222-0222 6.71 µM 1.49243601188826 0.0799030383427427 no 246 0.067792440136597 108 3982874 SGTC_1534 6-azauridine 81.6 µM 1.48601228359311 0.0808227639834335 no 247 0.0686379359687989 116 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1782 st039423 80.636 µM 1.48478975159322 0.0809987033618469 no 248 0.0687997637753126 88 2068169 SGTC_706 4262-0057 46.9 µM 1.47524586056085 0.0823821520137151 no 249 0.070073227969535 85 883298 SGTC_2695 st077686 51.995 µM 1.47349505365916 0.0826378628121495 no 250 0.0703087983069751 89 2876092 SGTC_1780 st038448 24.544 µM 1.46723858436726 0.0835565221149607 no 251 0.071155582070216 100 728868 YDL195W SEC31 SGTC_3245 9134821 49.47 µM 1.46554397932347 0.0838066627827363 no 252 0.0713862813143664 115 17014901 SGTC_2698 st077697 67.5 µM 1.45818336041969 0.0848996940519247 no 253 0.0723950044998765 103 3154499 SGTC_2423 st077119 87.2 µM 1.4540290665002 0.0855212946903309 no 254 0.0729691238935601 100 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3189 9110682 49.47 µM 1.45333482354039 0.085625504729765 no 255 0.0730654065184786 101 17122418 SGTC_163 TUB2.036 7.546 µM 1.45285933317975 0.0856969335300437 no 256 0.073131407032317 138 15992207 YJR013W GPI14 SGTC_2357 9067248 200 µM 1.45124352041996 0.085939996461216 no 257 0.0733560311192497 99 9150235 SGTC_1001 4048-4355 44.4 µM 1.45067948318879 0.086024964624634 no 258 0.0734345655473854 123 21824233 SGTC_952 1185-0122 232 µM 1.449373683682 0.0862219151335647 no 259 0.0736166269086099 94 678600 SGTC_2569 tetrandrine 100 µM 1.44926823821967 0.0862378339166955 no 260 0.0736313437088979 92 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1178 0988-0033 191 µM 1.44894407220202 0.0862867860484428 no 261 0.0736766009613186 93 5392207 SGTC_1461 k072-0203 53.8 µM 1.44841873772285 0.0863661606420675 no 262 0.0737499887632647 88 5418714 SGTC_1555 citronellol 128 µM 1.44148497245482 0.0874189286645989 no 263 0.0747238598960098 89 8842 A terpine precursor. SGTC_549 1661-1316 519 µM 1.43860878260518 0.0878584263722906 no 264 0.0751306982982526 117 2857282 SGTC_2553 4-methylesculetin 85.09 µM 1.43500394770935 0.0884115895559026 no 265 0.075642986329378 90 5319502 SGTC_422 cantharidin 155 µM 1.43441285397291 0.0885025402048747 no 266 0.0757272408306878 107 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1756 st041558 35.5 µM 1.42912829555975 0.0893187660966971 no 267 0.0764836810740839 112 3955792 SGTC_2416 tofa 880 nM 1.42824807412587 0.0894552629534819 no 268 0.0766102339283107 93 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1150 3909-7983 10.9 µM 1.42760247352145 0.0895554754978883 no 269 0.0767031556321344 132 23965914 SGTC_2218 6965428 192.983 µM 1.42693055933624 0.0896598611675383 no 270 0.0767999556582069 86 675684 SGTC_1707 st032323 6.317 µM 1.42104126588001 0.0905786703058919 no 271 0.0776523815929629 127 3132057 YMR211W DML1 SGTC_2459 5811157 9.22 µM 1.42068457031918 0.0906345432817414 no 272 0.0777042400695063 99 2870684 YBR192W RIM2 SGTC_2085 5307070 144.047 µM 1.41983543108079 0.0907676558182098 no 273 0.0778277986572474 125 2840351 SGTC_306 1672-3436 11.6 µM 1.41980931275346 0.0907717524709684 no 274 0.0778316015078624 108 6797378 SGTC_2988 9073640 71.4286 µM 1.417509675577 0.0911329880504652 no 275 0.0781669837658203 109 9102229 SGTC_688 0527-0193 473 µM 1.41571581429421 0.0914155138232121 no 276 0.0784293631490572 99 4007154 SGTC_2023 5144124 124 µM 1.41477417930072 0.0915640770564132 no 277 0.0785673585036857 109 2830192 SGTC_1870 st057514 26.5 µM 1.40684505015794 0.0928221708996399 no 278 0.0797366703243218 105 5393161 SGTC_331 k048-0133 24.5 µM 1.40568503097574 0.0930072947136924 no 279 0.0799088369324339 114 6813582 SGTC_3150 9097574 49.47 µM 1.40347703912116 0.0933604150670717 no 280 0.0802373170925606 97 17217476 SGTC_2095 5432005 200 µM 1.40294619719082 0.0934454591982722 no 281 0.080316441734046 109 783734 SGTC_693 4161-2696 114 µM 1.40003057372089 0.0939135803769992 no 282 0.0807520816059974 114 805759 SGTC_1170 0310-0127 64.8 µM 1.39935992011089 0.094021502336671 no 283 0.0808525397202301 116 774975 SGTC_3074 9116018 49.47 µM 1.39663708753743 0.0944606021531137 no 284 0.0812613658103124 108 17027303 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.39650965145837 0.09448119021365 no 285 0.0812805381342473 101 61125 An anti-inflammatory. SGTC_1072 oxiconazole 14.9 nM 1.39065022776622 0.0954313918084125 no 286 0.082165758683442 131 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2362 9071156 126 µM 1.38878800691981 0.0957348495639573 no 287 0.0824486116038595 111 653133 SGTC_1289 0976-0073 69.1 µM 1.38857510695725 0.0957695877956974 no 288 0.0824809956413499 108 3391136 SGTC_2681 menadione 3.18 µM 1.38770063471118 0.0959123700083634 no 289 0.0826141113419194 117 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_836 0330-0104 1.35 µM 1.38765095019128 0.0959204871027746 no 290 0.0826216793721636 105 46494820 SGTC_885 0865-0106 16.8 µM 1.38554349436524 0.0962652532243093 no 291 0.082943171300925 110 2793380 SGTC_1063 disulfiram 1.84 µM 1.38384879179975 0.0965431556189925 no 292 0.0832023797081073 113 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1816 st051957 91.6 µM 1.38316203620777 0.0966559395113143 no 293 0.083307593704508 100 674121 SGTC_789 1309-1135 70.6 µM 1.38269591502026 0.0967325443658322 no 294 0.083379062495059 96 3092424 SGTC_2889 9059656 51.95 µM 1.37648379639754 0.0977577374424477 no 295 0.084335950267138 119 3949838 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.37387238300483 0.098191071871161 no 296 0.0847406523563831 155 16725076 SGTC_2942 9052777 62.25 µM 1.36832782703991 0.0991157902056904 no 297 0.0856047421256421 135 6469503 SGTC_733 4069-0007 56.1 µM 1.36140999237779 0.100278453536479 no 298 0.0866920800388872 124 5717425 YNL287W SEC21 SGTC_2719 novobiocin 32.65 µM 1.36130453725018 0.10029625382108 no 299 0.0867087348677757 106 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1588 farnesol 29.9 µM 1.35989085521609 0.100535098805654 no 300 0.0869322326393767 117 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_655 k060-0012 42 µM 1.35759697388077 0.100923538075235 no 301 0.0872958018602751 129 5994525 SGTC_1278 0874-0585 172 µM 1.35565905743782 0.101252550998714 no 302 0.087603835959404 116 766306 SGTC_1013 4112-3890 241 µM 1.35522006618771 0.101327189903255 no 303 0.0876737266705126 123 705171 SGTC_2270 7924575 90.91 µM 1.35518692758478 0.101332825876969 no 304 0.0876790042737498 114 1262135 SGTC_2682 pyrogallin 40.03 µM 1.35017637291439 0.10218761458306 no 305 0.0884797075300668 113 822798 An ATP competetive kinase inhibitor. SGTC_1416 3966-0321 25.3 µM 1.34989995916443 0.102234922312778 no 306 0.0885240374029742 122 582530 YLR208W SEC13 SGTC_1483 3453-0561 55.9 µM 1.34366287197796 0.103306627436295 no 307 0.0895287142771644 131 4546991 SGTC_1706 st031321 9.9705 µM 1.34334472045201 0.103361512540391 no 308 0.0895801888529124 120 6103185 SGTC_1623 st003709 20.3 µM 1.34197553950977 0.103597954897555 no 309 0.0898019634205452 108 16192618 SGTC_1408 3909-7976 48.8 µM 1.3417492359683 0.103637072774459 no 310 0.0898386584510261 111 24152374 SGTC_1550 gossypolone 36.6 µM 1.34166520158525 0.103651601332411 no 311 0.0898522874305599 123 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_264 promethazine 12.5 mM 1.3407994875518 0.103801359159678 no 312 0.089992781324635 153 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3210 9128157 49.47 µM 1.33943900085068 0.104037023582724 no 313 0.0902138999927111 121 17590849 SGTC_407 eburnamonine 100 µM 1.33931381187013 0.104058728378185 no 314 0.0902342671023749 112 3195 SGTC_2513 baicalein 25.65 µM 1.33841643338355 0.104214408614572 no 315 0.0903803624252831 121 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1076 itraconazole 331 nM 1.33700664525984 0.104459324237277 no 316 0.0906102338560962 124 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1065 prochlorperazine maleate 2.48 µM 1.33408754364135 0.104967770730998 no 317 0.0910875838240523 133 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_647 0140-0236 81 µM 1.32837899799266 0.105967252659688 no 318 0.0920264670132395 110 990837 SGTC_1676 st018489 23.4 µM 1.32804938994625 0.106025171447678 no 319 0.0920808955836901 109 3696235 SGTC_1091 telmisartan 47.6 µM 1.32720694790795 0.106173309457817 no 320 0.0922201173460502 128 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2371 9071574 200 µM 1.32587318752295 0.106408148279707 no 321 0.0924408527763459 122 45596039 SGTC_2549 cedrol 20.94 µM 1.32562598982906 0.106451714217834 no 322 0.0924818065467485 136 6708665 A sedative which affects the nervous system. SGTC_2651 TUB2.036 5 µM 1.32505523116807 0.106552353493532 no 323 0.0925764166310913 146 15992207 YFL037W TUB2 SGTC_1724 st037281 8.293 µM 1.32362656206129 0.106804565300365 no 324 0.0928135495257687 118 574124 YDL195W SEC31 SGTC_1774 st048371 48.465 µM 1.32322857362162 0.106874901318268 no 325 0.0928796882333629 159 4242727 SGTC_782 0083-0095 30.5 µM 1.31887870724827 0.107645827449704 no 326 0.0936048328445538 113 3591729 An indicator and reagent. SGTC_55 0767-0285 6.563 µM 1.3161559244727 0.108130420165387 no 327 0.0940608568587579 114 3116166 SGTC_2135 5326629 150.42 µM 1.31461583260042 0.10840521547841 no 328 0.0943195231771754 109 5020077 SGTC_1485 3909-9022 254 µM 1.30863671538008 0.109476818327558 no 329 0.0953287189342869 116 714516 SGTC_3275 9138069 49.47 µM 1.30741031008948 0.109697556957166 no 330 0.0955366988254433 127 17617007 SGTC_175 3793-3120 23.7 µM 1.30519130696295 0.110097763327482 no 331 0.095913856766859 113 5322297 SGTC_284 0988-0104 32.6 µM 1.3017101427425 0.11072771436904 no 332 0.0965077455016235 122 4666532 SGTC_760 0568-0725 82.9 µM 1.29699981249373 0.111584201031495 no 333 0.0973156256572365 129 3916171 SGTC_1527 coumarin 137 µM 1.29038435943886 0.112795087225788 no 334 0.0984586199284913 138 323 A hepatotoxic, DNA x-linker. SGTC_1699 st031318 29.054 µM 1.28764047868246 0.113300067326369 no 335 0.0989355708987364 135 5340658 SGTC_130 0136-0219 337.655 µM 1.28469139000356 0.113844609462606 no 336 0.0994500741002051 135 234244 SGTC_3123 9126162 49.47 µM 1.28305487284435 0.114147591851026 no 337 0.0997364261535425 113 25239884 SGTC_566 0958-0068 16.5 µM 1.28269542091224 0.114214217111971 no 338 0.0997994023996668 132 6815365 SGTC_2528 xanthyletin 44.79 µM 1.2826603492896 0.114220719202303 no 339 0.0998055485290796 131 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2072 5231554 129 µM 1.28165799774866 0.114406661231115 no 340 0.0999813225995717 134 789545 SGTC_2496 diffractaic acid 79.83 µM 1.28020856482183 0.11467592040957 no 341 0.100235897261814 126 94870 An apoptosis inducer which activates caspases. SGTC_3352 9151559 45.5865 µM 1.2766775410925 0.11533376044684 no 342 0.100858056825281 107 17159339 SGTC_502 l-744,832 89.3 µM 1.27519744084806 0.115610303715927 no 343 0.10111968344739 116 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.27478604803032 0.11568725231523 no 344 0.101192490149724 132 676296 Flavone; oxidizing agent. SGTC_2470 5664817 21.68 µM 1.26540906360783 0.117451034794276 no 345 0.102862363914609 122 2859561 SGTC_2561 acetosyringone 100 µM 1.25783410458862 0.118889701073529 no 346 0.104225879443268 139 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2687 chenodiol 100 µM 1.25610836105124 0.119219194528908 no 347 0.104538342571156 125 5702181 A cholesterol synthesis inhibitor. SGTC_1462 k081-0014 26.5 µM 1.25592347300317 0.119254533096926 no 348 0.104571858605855 107 3270634 SGTC_3191 9110352 49.47 µM 1.25287742567829 0.119837803686938 no 349 0.105125159250465 123 17122424 SGTC_2337 9009472 200 µM 1.25055725646568 0.120283427385805 no 350 0.105548026729414 130 5742383 SGTC_810 3825-7150 143 µM 1.24816587526648 0.120743948786608 no 351 0.105985158998667 95 22330411 YGL099W LSG1 SGTC_495 decylubiquinone 155 µM 1.24666325547025 0.121033950683225 no 352 0.106260498631646 129 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_17 0960-0276 49.807 µM 1.24558727112602 0.121241913852338 no 353 0.106457978885367 150 6821114 SGTC_1336 1486-0901 104 µM 1.24225078347734 0.121888377965306 no 354 0.107072023985164 127 5006114 SGTC_1659 st012954 42.1 µM 1.24170722122848 0.121993925292587 no 355 0.107172302331797 123 24207262 SGTC_160 3453-0671 289.699 µM 1.23810861495125 0.122694311414583 no 356 0.107837894976188 136 5322268 SGTC_2236 dapsone 200 µM 1.23302084974103 0.123689333365635 no 357 0.108783992721947 109 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_174 3553-0389 74.3 µM 1.23114410643179 0.124057793486908 no 358 0.109134485884217 128 738071 SGTC_2728 chlorpromazine 9.18 µM 1.22923310056979 0.124433768832717 no 359 0.109492210892003 133 2726 A thorazine and dopamine antagonist. SGTC_1881 5652484 16 µM 1.22907408617179 0.124465089531083 no 360 0.109522015021 117 2255129 SGTC_1728 st035614 33.7865 µM 1.22391362323263 0.125484527253225 no 361 0.11049240692038 154 15945546 SGTC_963 1269-2853 151 µM 1.22385206835329 0.125496722346733 no 362 0.110504019000903 125 3668223 SGTC_2195 6536160 144.242 µM 1.22374920066963 0.125517104072249 no 363 0.110523426528441 116 3834386 SGTC_1134 3477-0009 42.5 µM 1.22257214308703 0.125750485251614 no 364 0.110745670002319 148 3973534 SGTC_3012 9080433 71.4286 µM 1.22089085232197 0.126084368022017 no 365 0.111063674233568 158 17688859 SGTC_3255 9139072 49.47 µM 1.21464643479299 0.127329837277771 no 366 0.112250485243152 126 17646060 SGTC_999 SEC7.066 22.7 µM 1.21404808945091 0.127449626915214 no 367 0.112364680517943 157 740511 YDR170C SEC7 SGTC_2776 terbinafine 19.92 µM 1.21387486453549 0.127484321427977 no 368 0.112397756290677 128 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2256 7954252 200 µM 1.21233933515651 0.127792153501136 no 369 0.112691256269803 134 2972920 SGTC_617 3770-0098 35 µM 1.21150948476758 0.127958730901928 no 370 0.112850100894734 133 5962639 SGTC_3250 9135583 49.47 µM 1.21028248486373 0.12820530519232 no 371 0.113085258116533 134 7699353 SGTC_2775 cyproheptadine 69.59 µM 1.20870269810725 0.128523260141122 no 372 0.113388542372172 134 2913 A selective serotonin reuptake inhibitor. SGTC_1061 3448-9325 110 µM 1.20642959258234 0.128981715148697 no 373 0.113825945743524 147 723482 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.20586697497266 0.129095362475545 no 374 0.113934393096333 161 442882 SGTC_1365 1672-3266 55.4 µM 1.20217907705084 0.129842027538495 no 375 0.114647076939149 165 6415873 SGTC_1848 st056003 16.4 µM 1.20169147670125 0.12994097221559 no 376 0.114741542315624 139 146492 SGTC_1745 st081495 74 µM 1.20156071094698 0.12996751629468 no 377 0.114766885666929 152 13842402 YBL026W LSM2 SGTC_417 st075190 100 µM 1.20057348056689 0.130168034865903 no 378 0.114958346608468 157 222757 SGTC_2219 9098279 200 µM 1.19892852369271 0.130502621061214 no 379 0.115277869758843 104 902349 SGTC_490 phenamil 164 µM 1.19807036604034 0.13067740722839 no 380 0.115444812159579 143 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2119 5528445 120.635 µM 1.19058056846623 0.132209770419437 no 381 0.116909141828126 132 791935 SGTC_99 0109-0120 622.8 µM 1.19030865550358 0.132265634085144 no 382 0.116962550028851 132 759414 SGTC_3294 9122953 26.2835 µM 1.18779132547381 0.13278358427291 no 383 0.117457816400787 135 16459826 SGTC_180 1486-1293 102.781 µM 1.18742844330323 0.132858363688259 no 384 0.117529333103938 148 4140536 SGTC_1353 1498-1206 8.11 µM 1.18714459729209 0.132916876268476 no 385 0.117585294869759 141 6756808 SGTC_3241 9133421 49.47 µM 1.18605529619182 0.133141591642801 no 386 0.117800231522719 139 17018221 SGTC_2656 pseudo-anisatin 100 µM 1.18370643731525 0.1336270345386 no 387 0.118264644934969 149 6708809 A neurotoxin. SGTC_2070 5230947 200 µM 1.18276647307006 0.133821639186729 no 388 0.118450855678971 158 2835538 SGTC_698 k064-0052 127 µM 1.1814550696391 0.134093469750685 no 389 0.118710996140419 147 5088751 SGTC_2356 9061756 188.97 µM 1.18101276040154 0.134185238064385 no 390 0.118798827091713 137 20104043 SGTC_1628 st004252 77.7 µM 1.17828657036077 0.134751807890192 no 391 0.119341189943407 141 692968 SGTC_308 4092-1169 104 µM 1.17769996039528 0.134873934265522 no 392 0.119458121356576 163 2268590 YDL196W YDL196W SGTC_3120 9124077 49.47 µM 1.17700524744579 0.135018664792873 no 393 0.119596705910293 149 18774327 YGL155W CDC43 SGTC_311 1315-0136 58 µM 1.17541344667035 0.135350688417089 no 394 0.119914673198668 129 6759207 SGTC_489 paxilline 115 µM 1.1752959768667 0.135375212852207 no 395 0.119938161757119 137 105008 A toxic potassium channel blocker. SGTC_3317 9138495 8.753 µM 1.17511395959213 0.135413219023324 no 396 0.119974563247067 158 17020139 SGTC_962 1254-0300 21.5 µM 1.17507258789033 0.13542185867368 no 397 0.119982838226879 137 7340576 SGTC_2620 irigenin 100 µM 1.17451230682433 0.135538899340406 no 398 0.120094942717234 163 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2606 farnesol 9.78 µM 1.17309808777425 0.13583463272563 no 399 0.120378236632153 168 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2420 aureobasidin a 50 nM 1.17163202453136 0.136141673626533 no 400 0.1206724124502 124 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3279 9140807 49.47 µM 1.17113421232332 0.136246039496663 no 401 0.120772416949621 140 45595718 SGTC_2867 9039098 71.43 µM 1.16920740604134 0.136650508612847 no 402 0.121160039011527 152 6463460 SGTC_2939 9044578 71.43 µM 1.16908267582248 0.136676719853146 no 403 0.121185161529127 141 2653634 SGTC_930 2810-3379 265 µM 1.16801197048205 0.136901862990274 no 404 0.12140096820072 151 1015764 SGTC_1883 5-benzylidenerhodanine 20 µM 1.16771854053703 0.136963608354464 no 405 0.121460157795535 147 1273210 SGTC_8 0354-0001 70 µM 1.16585555660386 0.137356073037162 no 406 0.12183642526938 162 4993152 SGTC_2614 arthonioic acid 13.39 µM 1.16533234947658 0.137466432221821 no 407 0.121942244711102 130 6710684 SGTC_3099 9120367 49.47 µM 1.16484320949539 0.137569660420315 no 408 0.122041232392493 155 24824940 SGTC_73 0327-0325 16.231 µM 1.15697923535513 0.139236540065518 no 409 0.123640422029476 108 53298 SGTC_3141 9094609 49.47 µM 1.1553270811677 0.139588477078631 no 410 0.123978255041431 184 25236309 YDL196W YDL196W SGTC_3353 9151644 39.2805 µM 1.15421807252041 0.139825053865026 no 411 0.12420538751164 152 4909158 SGTC_578 3460-0051 92 µM 1.15236504934806 0.140220953722643 no 412 0.124585548392299 189 2876744 SGTC_373 0844-0104 25.9 µM 1.15097613646347 0.14051819481113 no 413 0.124871026555056 164 5375804 SGTC_2044 5102272 200 µM 1.15060028054875 0.140598705177375 no 414 0.12494835876704 153 592666 SGTC_785 1270-0111 65.3 µM 1.14889140567023 0.14096515015108 no 415 0.125300380959812 151 6741994 SGTC_2164 5685496 200 µM 1.14477775022124 0.14184992237141 no 416 0.126150617191349 120 759046 SGTC_2062 5245942 200 µM 1.14369299219287 0.142083859240312 no 417 0.126375490330088 140 1376160 SGTC_2055 5235184 200 µM 1.14280995968384 0.142274485071321 no 418 0.126558751359118 143 2836034 SGTC_3104 9120930 49.47 µM 1.14240758338979 0.142361405961951 no 419 0.12664232028676 152 17014836 SGTC_1960 st011366 51.8 µM 1.14172883539413 0.142508109764701 no 420 0.126783375513605 167 3972846 SGTC_1966 st070145 16.1 µM 1.14131674931807 0.142597227435402 no 421 0.12686906726543 167 3748532 SGTC_977 1348-1378 135 µM 1.14086121987246 0.142695784007831 no 422 0.126963839813805 175 X977 SGTC_970 1315-0089 19.5 µM 1.14077034228972 0.142715451435815 no 423 0.126982752718931 145 6811083 YLR033W RSC58 SGTC_2596 sinensetin 100 µM 1.14012783702368 0.14285455259427 no 424 0.127116523055299 148 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2487 5918373 44.05 µM 1.13970054106188 0.142947112070137 no 425 0.127205540840366 179 2876279 SGTC_170 4197-0004 226 µM 1.13965885636155 0.142956143844912 no 426 0.127214227258934 167 218692 SGTC_3109 9122853 49.47 µM 1.13784299596958 0.143349958474417 no 427 0.127593023845913 183 1234709 SGTC_3080 9117754 49.47 µM 1.13775218682083 0.14336967191897 no 428 0.127611987606591 170 9550191 SGTC_1331 1472-0049 76.2 µM 1.13766449199061 0.143388711024241 no 429 0.127630302860934 174 24051409 SGTC_228 caffeine 993.056 µM 1.13656956697717 0.143626569929299 no 430 0.127859134165566 115 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1237 0330-0133 46.1 µM 1.13432202735514 0.144115654016765 no 431 0.128329746339109 181 X1237 YHR072W ERG7 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.13274190768611 0.14446017326466 no 432 0.128661326634537 146 5379071 SGTC_1670 st016595 4.04 µM 1.12829025024815 0.145433766576704 no 433 0.129598679833473 167 597879 SGTC_2484 5809818 12.04 µM 1.12739088317185 0.145630995988585 no 434 0.129788625975958 150 2870548 SGTC_1389 3405-0187 19 µM 1.12394448600938 0.146388448395912 no 435 0.130518288692007 148 799890 SGTC_2582 agaric acid 100 µM 1.1231888972913 0.146554865277167 no 436 0.130678638482917 184 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1696 st025591 34.7925 µM 1.12184075305171 0.146852106588629 no 437 0.130965077600225 142 2787147 SGTC_2455 5377712 9.75 µM 1.12004241517101 0.147249236517345 no 438 0.131347843893092 148 2243908 SGTC_2826 7992541 19.48 µM 1.1199266438734 0.147274827124082 no 439 0.131372511612108 166 2985066 SGTC_339 3091-4833 71.4 µM 1.11886852255262 0.14750885712929 no 440 0.131598116746843 177 3240077 SGTC_90 0870-0863 4.608 µM 1.11863360026507 0.147560849851219 no 441 0.131648241465203 176 1738164 SGTC_197 4544-0043 41.561 µM 1.11810565027473 0.147677739907681 no 442 0.131760936766077 171 896523 SGTC_2445 5742597 35.57 µM 1.11316441115776 0.148774754209141 no 443 0.132818912172623 175 1774255 SGTC_144 4161-2749 112.381 µM 1.11184352830055 0.149068926237403 no 444 0.133102716373248 178 797501 YMR168C CEP3 SGTC_1123 mangostin 811.285 nM 1.11179849576695 0.149078962216013 no 445 0.133112399391766 98 5281650 An antioxidant. SGTC_1829 berberine 14.4 µM 1.11167703760898 0.149106032707187 no 446 0.133138518074207 176 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1258 0671-0043 57.1 µM 1.11094915953191 0.149268330346901 no 447 0.133295116797064 176 4298767 SGTC_1822 st052468 42 µM 1.1101672977204 0.149442796292629 no 448 0.133463470930251 163 2873678 SGTC_2677 mitomycin C 100 µM 1.10924280373786 0.149649264973874 no 449 0.133662725921423 161 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2278 7948257 134.34 µM 1.1091224010909 0.149676168685908 no 450 0.133688691193648 148 1247028 SGTC_2353 9059630 146.67 µM 1.10886391664796 0.149733937377512 no 451 0.133744446024815 156 4779114 SGTC_318 1488-0629 67.2 µM 1.10742757923971 0.150055215383722 no 452 0.134054553729941 146 3662576 SGTC_2750 bromebric acid 70.15 µM 1.1072287414424 0.150099727341747 no 453 0.134097522047504 149 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2317 5986382 200 µM 1.10593638969541 0.150389248553433 no 454 0.134377026407709 174 877883 SGTC_1949 st076024 69.1 µM 1.10530744291341 0.15053028389843 no 455 0.134513196966039 186 2921930 SGTC_649 1123-0311 367 µM 1.10461939681522 0.150684672579613 no 456 0.13466227132433 173 693629 YIL048W NEO1 SGTC_2904 7225135 42.03 µM 1.10398029280304 0.150828173713852 no 457 0.134800843264087 197 4446116 SGTC_429 1112-0049 25.5 µM 1.10019406754582 0.151680178820693 no 458 0.135623787421616 145 2836170 SGTC_1571 st070080 73.4 µM 1.09888801601981 0.151974817010489 no 459 0.135908457244571 148 4315245 SGTC_1153 4055-0057 267 µM 1.09835349678166 0.152095511233238 no 460 0.136025080116127 177 882706 SGTC_3094 9117742 49.47 µM 1.09721379905973 0.152353067010866 no 461 0.136273971193156 194 17149698 SGTC_1308 1187-1617 41.4 µM 1.09469763377538 0.15292270977513 no 462 0.136824562807543 161 2882570 SGTC_845 0330-0138 4.51 µM 1.09394751367557 0.153092804785657 no 463 0.136988999204456 178 9039800 SGTC_2956 9076196 2.52 µM 1.0939096490396 0.153101394181813 no 464 0.13699730321989 173 16423868 SGTC_3015 9080845 49.47 µM 1.09220865755925 0.153487584751488 no 465 0.137370698995503 160 5296973 SGTC_1182 1222-0449 220 µM 1.09207071885018 0.153518930407386 no 466 0.13740100925847 151 658318 SGTC_1219 1469-0211 33.1 µM 1.08797364978154 0.154451895176989 no 467 0.138303370160352 176 6822282 SGTC_2232 chlorophetanol 41.5365 µM 1.08490704765614 0.155152654593602 no 468 0.138981413121111 164 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1657 st012939 43.4 µM 1.08385225264811 0.155394173690237 no 469 0.139215156439648 135 24207257 SGTC_2301 7769476 200 µM 1.08358496628547 0.155455414305325 no 470 0.13927442974595 163 977820 SGTC_2877 9040724 71.43 µM 1.08167411195559 0.155893692787337 no 471 0.139698680146246 141 6463895 SGTC_1660 st012960 28.1 µM 1.07825594306825 0.156679722724952 no 472 0.14045977621577 160 24207266 SGTC_960 1222-0186 7.7 µM 1.07775801217467 0.156794442445241 no 473 0.14057088094311 167 3126296 SGTC_305 1682-2595 20.8 µM 1.0775846295536 0.156834401533861 no 474 0.140609582296236 171 226033 SGTC_1166 k206-0078 225 µM 1.0766583151208 0.157048000588143 no 475 0.140816470770562 171 5404595 SGTC_917 harmaline 728.087 nM 1.0759664629935 0.157207659694256 no 476 0.14097112773543 162 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3228 9131799 49.47 µM 1.07584333406542 0.157236085409997 no 477 0.140998664108662 173 17015818 SGTC_3092 9117248 49.47 µM 1.07574138633429 0.157259623762408 no 478 0.141021466310606 180 17141857 SGTC_2873 9040596 71.43 µM 1.07466664390046 0.157507908197555 no 479 0.141262001393243 182 6463863 SGTC_771 0250-0039 27.3 µM 1.07212342879695 0.158096461161235 no 480 0.141832298465318 180 3005115 SGTC_2913 7966556 36.57 µM 1.07138011847603 0.158268750919931 no 481 0.141999274309271 165 2976516 SGTC_2512 diallyl trisulfide 49.23 µM 1.07112290818347 0.158328397634228 no 482 0.142057084529124 189 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1873 rapamycin 2 nM 1.06966388913784 0.158667021226524 no 483 0.14238531304748 158 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1034 k072-0165 12.7 µM 1.06862346607654 0.15890878274334 no 484 0.142619685158584 191 5835461 SGTC_209 4077-0173 175.592 µM 1.06826744445204 0.158991566353838 no 485 0.142699944655296 156 15993494 SGTC_210 3551-0445 56.827 µM 1.06568089400419 0.159593849953711 no 486 0.143283958658149 156 2865180 YOR207C RET1 SGTC_3079 9117512 49.47 µM 1.05557704589019 0.161960841651206 no 487 0.145580746244225 206 7185044 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.05513298988211 0.162065390997577 no 488 0.145682252969956 171 4620898 SGTC_2832 7992762 51.95 µM 1.05481384240114 0.162140558796763 no 489 0.145755236246877 162 2985177 SGTC_2241 6772625 37.8075 µM 1.0537492915144 0.16239145324319 no 490 0.145998857541279 174 2285411 SGTC_1017 4239-0030 168 µM 1.05315824103126 0.162530861663071 no 491 0.146134236843275 160 1149593 SGTC_256 clotrimazole 625 nM 1.04976748313327 0.163332128800027 no 492 0.146912514375908 155 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3272 9137413 49.47 µM 1.04901232331621 0.163510928796819 no 493 0.147086223341932 180 17614870 SGTC_594 1487-1584 10.8 µM 1.04536550500496 0.164376178238888 no 494 0.147927036593611 183 5013332 SGTC_1633 st005664 67.9 µM 1.04438314321589 0.164609761402113 no 495 0.148154079713532 158 2063822 SGTC_2376 9072922 81.32 µM 1.0441613240663 0.164662534674529 no 496 0.148205378732389 168 17087968 SGTC_2171 5739187 198.077 µM 1.04299161123736 0.164941003818453 no 497 0.148476088993641 150 2262761 SGTC_2732 terfenadine 20 µM 1.04094638317796 0.165428635916264 no 498 0.148950216539179 201 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2197 6588183 93.1375 µM 1.04021741248749 0.165602665474525 no 499 0.149119451771045 161 884136 SGTC_2653 dihydrofissinolide 100 µM 1.03991254135187 0.165675483458406 no 500 0.149190267636941 168 6857746 SGTC_1721 st082152 9.2685 µM 1.03689481106124 0.166397380030739 no 501 0.149892441237383 168 5296051 SGTC_2784 7567673 72.73 µM 1.03647006751934 0.166499149301609 no 502 0.14999144835903 174 3471247 SGTC_2565 isoliquiritigenin 100 µM 1.03348537944062 0.1672154185242 no 503 0.150688404562689 177 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1300 1094-0077 113 µM 1.03018754603673 0.168009143045281 no 504 0.151460987403832 180 5532636 SGTC_3227 9130768 49.47 µM 1.02932676610748 0.168216714474356 no 505 0.151663074836989 165 17720899 SGTC_1411 3909-8223 150 µM 1.029227856662 0.168240576401153 no 506 0.151686307526427 186 X1411 SGTC_1516 st013856 110 µM 1.02697309035175 0.16878512983409 no 507 0.152216567711757 168 5281404 A mutagen and neurotoxin. SGTC_1344 1488-0097 29.1 µM 1.02584318530317 0.169058441134452 no 508 0.152482753233893 188 747966 SGTC_2700 st077718 96.8 µM 1.02534459835907 0.169179134029916 no 509 0.152600309612622 173 904970 SGTC_1857 st056007 79.3 µM 1.02315776306224 0.169709154320862 no 510 0.153116629723853 161 619834 SGTC_1471 k673-0312 37 µM 1.02100593460588 0.170231728461956 no 511 0.153625813511379 187 24099884 SGTC_892 0929-0076 29 µM 1.02020441000363 0.170426642931976 no 512 0.153815763282726 175 5751038 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.02010480803133 0.170450874084961 no 513 0.153839378368139 174 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2401 5128683 200 µM 1.02001498906251 0.170472727122141 no 514 0.153860676014253 166 708373 SGTC_523 1934-0222 13.7 µM 1.01699516142273 0.171208498026802 no 515 0.154577865601251 188 1361595 SGTC_2865 9030313 51.95 µM 1.01548808551972 0.171576450454217 no 516 0.154936611564801 158 42562754 SGTC_2467 5474540 200 µM 1.01342465662371 0.172081055247364 no 517 0.155428683540666 186 5413519 SGTC_2782 7736369 71.43 µM 1.01178048979322 0.172483808262627 no 518 0.155821510234847 190 2950836 YOL077C BRX1 SGTC_1195 1502-0147 41.1 µM 1.00951577392068 0.173039553679291 no 519 0.156363670275396 165 817940 SGTC_68 0986-0284 82.829 µM 1.00756114973791 0.173520120817129 no 520 0.156832593837743 155 423278 YIL048W NEO1 SGTC_2166 5933061 31.504 µM 1.00707392489198 0.173640042848301 no 521 0.15694962530727 171 2877375 SGTC_2244 6635614 200 µM 1.00664854001557 0.17374478713998 no 522 0.15705184977372 162 836499 SGTC_44 0929-0055 61.211 µM 1.00585216751092 0.173940989294936 no 523 0.157243344185511 198 1379590 SGTC_346 4513-0042 7.16 µM 1.00551376563521 0.174024403941303 no 524 0.157324762197239 187 2827372 SGTC_1884 5633444 25 µM 1.00476260301514 0.174209653245712 no 525 0.157505587655788 195 5724239 SGTC_2319 6033012 152.6 µM 1.00180326381139 0.174940694787589 no 526 0.15821931029571 190 847246 SGTC_1323 1348-1351 11.2 µM 1.00161896640367 0.174986285824366 no 527 0.158263828566602 183 6989654 SGTC_2294 7971431 200 µM 1.00028340239945 0.175316899578192 no 528 0.158586688564704 182 5741572 SGTC_664 1222-0054 14.9 µM 0.995197076051992 0.176579623496274 no 529 0.159820211808054 183 6813991 SGTC_1156 4092-0367 4.88 µM 0.99465386190934 0.17671482015547 no 530 0.159952320728071 213 1357585 SGTC_1125 tnp00248 1.32998 µM 0.993831938366909 0.176919507179136 no 531 0.160152347130682 203 24207736 SGTC_897 1000-0139 31.4 µM 0.990941920428531 0.177640409311614 no 532 0.160856970576586 183 6151020 SGTC_607 4491-0986 66.8 µM 0.990616205456554 0.17772177353139 no 533 0.160936510777901 167 698981 YDR232W HEM1 SGTC_717 1532-0246 73.2 µM 0.990522740284632 0.177745125649997 no 534 0.16095933988618 173 9561992 SGTC_330 1488-0319 80.1 µM 0.990241179218352 0.177815484915437 no 535 0.161028124673737 199 6846614 SGTC_3180 9109287 49.47 µM 0.989170999983873 0.178083072151789 no 536 0.161289742252965 201 18891271 SGTC_995 3931-2021 34.6 µM 0.988023020626414 0.178370394565096 no 537 0.16157068700459 180 730143 SGTC_2006 4011487 200 µM 0.987711677349296 0.178448369546904 no 538 0.161646936942829 189 45595294 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.987381035743606 0.178531201243997 no 539 0.161727938841114 217 5393153 SGTC_81 0411-0046 9.971 µM 0.985916371245997 0.178898417339088 no 540 0.162087076266488 205 12925265 SGTC_3102 9121669 49.47 µM 0.985239225396077 0.179068349800498 no 541 0.162253288644011 200 41905072 SGTC_2472 5377652 49.4 µM 0.981460316172746 0.18001854596365 no 542 0.163182897342237 201 1610903 SGTC_2365 9042475 200 µM 0.981445478773107 0.180022283014967 no 543 0.163186554139018 197 6464479 SGTC_1088 bifonazole 369 nM 0.981189558293202 0.180086748603919 no 544 0.163249636185326 183 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_3153 9100258 49.47 µM 0.980976055236721 0.180140540460479 no 545 0.163302274847839 183 25236848 SGTC_2326 6164455 177.58 µM 0.980738384992761 0.180200433074912 no 546 0.163360884840597 201 2888790 SGTC_1218 1348-1416 30.7 µM 0.980495167396013 0.180261736553358 no 547 0.163420876967681 192 6787668 SGTC_76 0433-0009 400.328 µM 0.979869394593266 0.180419523980162 no 548 0.1635752960445 181 2841569 SGTC_2842 9000675 19.48 µM 0.978219788252456 0.180835884206164 no 549 0.163982815739662 201 2989072 SGTC_2165 5727197 32.143 µM 0.977931967776456 0.180908591683396 no 550 0.164053986509178 197 1361712 SGTC_2136 5328288 199.296 µM 0.977796948082666 0.180942705858504 no 551 0.164087380389705 159 262395 SGTC_3350 9150499 3.57 µM 0.976617928438281 0.181240769106776 no 552 0.164379169943949 198 4910996 YPR165W RHO1 SGTC_1607 st000305 50.6 µM 0.976579253438062 0.181250551585167 no 553 0.16438874711705 180 5457690 SGTC_3356 9151811 4.48 µM 0.975451570851403 0.181535933690324 no 554 0.164668156609195 216 1859254 YPR165W RHO1 SGTC_404 fumagillin 50 µM 0.975206066908246 0.181598100517127 no 555 0.164729026662794 201 12015870 A methionine aminopeptidase binder. SGTC_2851 9015922 71.43 µM 0.975129041758883 0.181617607670697 no 556 0.164748127221207 210 2996893 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.974683336647841 0.181730511328679 no 557 0.164858680545224 210 279621 SGTC_49 0717-0965 32.132 µM 0.972438192198317 0.182299906912043 no 558 0.165416299758363 194 5889349 YGL099W LSG1 SGTC_1702 st027038 51 µM 0.971677565294949 0.182493063571764 no 559 0.165605490585251 166 5521182 SGTC_369 0957-0393 4.5 µM 0.970795082025984 0.182717325060711 no 560 0.165825166049935 187 6997992 SGTC_872 0588-0139 234 µM 0.969687030541153 0.182999152716753 no 561 0.166101258546714 163 2047100 SGTC_1684 st024538 14.6195 µM 0.968506367481279 0.183299747088391 no 562 0.16639577024712 192 6732859 SGTC_585 0kpi-0023 191 µM 0.967884328072462 0.183458240800856 no 563 0.166551071034316 155 64601 SGTC_1731 st035964 63 µM 0.966537559510854 0.183801685849098 no 564 0.16688763098778 194 6739575 SGTC_2979 9012552 45.46 µM 0.965769808469642 0.183997652344605 no 565 0.167079689583233 210 17100905 SGTC_204 PMA1.184 62.41 µM 0.964596065634167 0.184297498575318 no 566 0.167373585399596 203 2252213 YGL008C PMA1 SGTC_2321 7390090 138.78 µM 0.964440024350037 0.184337384017694 no 567 0.167412681962242 168 649046 SGTC_1498 4478-3555 97.6 µM 0.963550586641854 0.184564834191213 no 568 0.167635645324791 168 3437919 SGTC_1423 4048-0112 5.59 µM 0.961801663837875 0.185012583682418 no 569 0.168074621057604 194 X1423 SGTC_2991 9074669 71.4286 µM 0.961302864651363 0.185140407059492 no 570 0.168199953991848 221 17333109 SGTC_2124 5246320 200 µM 0.960672899365516 0.185301921714888 no 571 0.168358330842984 214 579342 SGTC_2937 9044753 11.33 µM 0.959866260868573 0.185508860704211 no 572 0.168561264322893 181 6465530 YGL099W LSG1 SGTC_1443 4112-3303 14 µM 0.959392755824809 0.185630402789677 no 573 0.168680461566954 208 704433 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.959202558278776 0.185679237731321 no 574 0.168728355973175 214 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1164 k060-0068 93.7 µM 0.959145584862002 0.185693867723076 no 575 0.168742704378426 199 5963676 SGTC_1761 st044296 37 µM 0.958259231840118 0.185921563116201 no 576 0.168966027930499 201 1826700 SGTC_3057 9095946 49.47 µM 0.958071169531603 0.185969896732281 no 577 0.16901343609814 218 24540043 SGTC_292 k038-0015 474 µM 0.956470674269444 0.186381552878215 no 578 0.169417246735265 196 46368540 SGTC_1562 morin hydrate 59.1 µM 0.956172258340099 0.18645836948026 no 579 0.169492606562856 183 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_967 1306-0166 352 µM 0.956017932466662 0.186498102897085 no 580 0.169531587353569 220 4437607 SGTC_2592 piperlongumine 83.33 µM 0.955522449880285 0.186625707460293 no 581 0.16965677895139 208 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2673 kobusone 100 µM 0.95482231989031 0.186806108215442 no 582 0.169833779058966 234 6710676 An epoxy ketone and protein crosslinker. SGTC_2433 5607874 27.82 µM 0.95401910570521 0.187013203305111 no 583 0.170036985705686 211 2252428 SGTC_2228 7354201 200 µM 0.95355591145027 0.1871326945952 no 584 0.170154240897174 224 753451 SGTC_2417 cerulenin 830 nM 0.95187449561517 0.187566850006148 no 585 0.170580317778619 186 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2485 5633444 17.78 µM 0.94867019860889 0.188395947386519 no 586 0.171394187789081 197 5724239 SGTC_2502 avocadyne acetate 18.59 µM 0.945464605022815 0.18922763830084 no 587 0.172210866407323 183 3952079 SGTC_1751 st044839 27.194 µM 0.942809534126039 0.189918204923692 no 588 0.172889167085832 184 5291326 SGTC_450 aminopyrene 156 nM 0.941665822157843 0.190216153784 no 589 0.173181879294637 206 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_985 1493-0307 8.71 µM 0.941391906946614 0.190287554147715 no 590 0.173252029713359 202 3278274 SGTC_1818 st052136 56.3 µM 0.940382489825275 0.190550816898252 no 591 0.173510700313347 205 674169 SGTC_3140 9094243 49.47 µM 0.939219284822606 0.190854465714167 no 592 0.173809084840374 229 19291112 SGTC_261 5-fluorouridine 15.376 µM 0.935558627378738 0.191811997544233 no 593 0.174750242256215 184 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3028 9087778 49.47 µM 0.935432699473484 0.191844989221751 no 594 0.174782675857472 196 17217395 SGTC_2907 7721985 69.9 µM 0.93510794396369 0.191930087498625 no 595 0.174866336512914 179 3267881 SGTC_1910 st062352 60.4 µM 0.934351542432058 0.192128382986224 no 596 0.175061292529871 189 2245730 SGTC_14 0354-0009 295 µM 0.93277539313681 0.192541983111693 no 597 0.175467974335664 219 1713507 SGTC_299 1273-0059 1.44 µM 0.931745043135044 0.192812653034782 no 598 0.175734151131735 195 2848077 SGTC_2911 7942208 15.64 µM 0.928788482447667 0.193590622419576 no 599 0.176499357251096 181 1243384 SGTC_2715 st079500 56.4 µM 0.928060808627989 0.193782390754426 no 600 0.176688013807555 218 28246688 SGTC_2621 lithochol-11-enic acid 100 µM 0.926849642445031 0.194101833462613 no 601 0.177002303083436 206 6708711 SGTC_2434 5670830 169.91 µM 0.923423316803024 0.195007256035265 no 602 0.177893322632577 209 1549830 SGTC_3206 9114350 49.47 µM 0.923314247500264 0.195036120215615 no 603 0.177921732598549 189 17087243 SGTC_1303 1160-0052 261 µM 0.920704148570875 0.195727633260838 no 604 0.178602454835162 193 3562476 SGTC_1914 st062367 72.6 µM 0.920676087658191 0.1957350757253 no 605 0.178609782111872 207 978205 SGTC_1523 st012844 44.7 µM 0.918184372859602 0.196396626237087 no 606 0.17926117428623 170 4274103 SGTC_3158 9100007 49.47 µM 0.917786753801821 0.196502319377684 no 607 0.179365259208288 191 19297233 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.915971582593409 0.196985256918179 no 608 0.179840899943994 196 6708514 SGTC_1744 st037937 38.9 µM 0.915920588958183 0.196998834457539 no 609 0.179854273558194 204 1016152 SGTC_361 000s-0510 1.45 µM 0.914662012466342 0.197334121889109 no 610 0.180184546353827 204 660 SGTC_1149 3909-7961 23.3 µM 0.913513632581045 0.197640353658317 no 611 0.180486233522988 192 735261 SGTC_79 0052-0007 94.094 µM 0.904557472270118 0.200038482034354 no 612 0.182849937019118 204 2801472 SGTC_1947 st076332 61.6 µM 0.903750410920061 0.200255439068359 no 613 0.183063880949802 224 24208416 SGTC_71 0417-1750 47.813 µM 0.903049521653723 0.200443969222298 no 614 0.183249806369282 198 6811472 SGTC_1245 0418-0076 17.2 µM 0.902081747264663 0.200704463182337 no 615 0.183506722087971 204 6790114 SGTC_1995 st072814 61.1 µM 0.901843264705048 0.200768686266834 no 616 0.183570066675631 194 5769371 SGTC_171 k064-0041 9.68 µM 0.901814376428563 0.200776466684597 no 617 0.183577740765564 202 53325 SGTC_3348 9149464 3.537 µM 0.901638084981585 0.200823950804941 no 618 0.183624576428589 182 1951442 SGTC_1815 st051655 58.2 µM 0.899356238086641 0.201439174481211 no 619 0.184231470517197 212 5984156 SGTC_925 2064-1272 59.6 µM 0.898503027967526 0.201669503863632 no 620 0.184458715820458 212 6815817 SGTC_2343 7990716 14.84 µM 0.897759224062515 0.201870427003878 no 621 0.184656963892213 218 6456862 SGTC_1481 3346-2004 36 µM 0.897518713937655 0.201935421440434 no 622 0.184721096041996 238 2770522 SGTC_855 0428-0020 25 µM 0.896854469692297 0.202114989049268 no 623 0.184898289034939 203 6812414 SGTC_574 1315-0397 40 µM 0.895088022986602 0.202592983809762 no 624 0.185370017956054 245 6794277 SGTC_1604 st002052 72.4 µM 0.894837130738397 0.202660929198133 no 625 0.185437079181598 200 6254834 YHR062C RPP1 SGTC_2202 7226349 200 µM 0.894651841984115 0.202711116916702 no 626 0.18548661485381 183 844334 SGTC_1859 st055998 20 µM 0.892966935797936 0.203167835043712 no 627 0.185937439745142 207 676301 SGTC_1120 ficusin 1.78878 µM 0.892303901546337 0.203347728329918 no 628 0.186115031804392 209 6199 A DNA cross-linker. SGTC_2699 st077704 54.6 µM 0.891281350033644 0.203625351454167 no 629 0.186389125685636 196 645852 SGTC_12 0849-0099 9.267 µM 0.890409938154022 0.203862118395936 no 630 0.186622903984583 208 6071388 SGTC_1880 MG-132 525 µM 0.889932668228055 0.203991864522118 no 631 0.186751020637996 216 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_215 1287-0124 461.5 µM 0.889464687326259 0.204119133182478 no 632 0.186876696627522 211 5560863 SGTC_3192 9110362 49.47 µM 0.889278239641247 0.204169851302292 no 633 0.186926781617245 217 16649480 SGTC_1612 st002233 45.4 µM 0.889257659064998 0.204175450159069 no 634 0.186932310636525 215 1035021 SGTC_2686 alizarin 95.37 µM 0.889111555022996 0.204215199760646 no 635 0.18697156473342 190 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_567 1080-0542 68.4 µM 0.888754300594307 0.204312415120335 no 636 0.187067570552394 179 5950415 SGTC_1925 st057770 10.1 µM 0.887826837092326 0.204564923214748 no 637 0.187316952297328 199 5989122 SGTC_248 streptozotocin 5.23457 mM 0.887356630526746 0.204693010978793 no 638 0.187443462634457 226 5300 DNA alkylating agent. SGTC_1370 2001-0092 44.6 µM 0.887276037981611 0.204714969775684 no 639 0.187465151575067 218 790957 SGTC_1388 3346-4487 254 µM 0.886374530530096 0.204960696160368 no 640 0.187707869562893 221 3345614 SGTC_2132 5317594 122.667 µM 0.886368246589895 0.204962409606534 no 641 0.187709562104911 235 794577 SGTC_1290 0986-0249 10.2 µM 0.886270101182697 0.204989172085313 no 642 0.187735998211608 219 53329 SGTC_1513 0337-0559 19 µM 0.886212449809756 0.20500489354125 no 643 0.187751528057737 204 775073 SGTC_1904 st060225 78 µM 0.885890027524026 0.20509283090006 no 644 0.187838395230298 195 66595 SGTC_1565 sinapyl alcohol 95.1 µM 0.884957667563994 0.205347248595033 no 645 0.188089731742531 219 5280507 A phenol propionate derived from cinnamic acid. SGTC_612 0302-0167 22.4 µM 0.883455197421744 0.205757629309493 no 646 0.188495189515656 228 235821 SGTC_1621 st003705 32.4 µM 0.882671226207429 0.205971954215496 no 647 0.18870696643351 209 24207032 SGTC_2585 alliin 100 µM 0.88224448590862 0.206088673667149 no 648 0.188822304919309 210 87310 A garlic compound which reacts with lipids. SGTC_428 3448-4153 16.5 µM 0.882096440871699 0.20612917522075 no 649 0.188862328373392 201 3834874 SGTC_1395 3486-0190 4.35 µM 0.879353293745166 0.206880487657369 no 650 0.189604874043316 213 6748079 SGTC_1253 0550-0034 176 µM 0.879140599963532 0.2069388093572 no 651 0.189662523300171 204 5969915 SGTC_835 0312-0010 67.2 µM 0.879022048136878 0.206971321084337 no 652 0.189694660675722 232 1626196 SGTC_2372 9071633 200 µM 0.878858834095539 0.207016085950004 no 653 0.189738910694397 201 21321366 SGTC_3002 9075603 71.4286 µM 0.878737083591596 0.207049482303321 no 654 0.189771923397884 237 20105405 SGTC_2378 9074213 121.43 µM 0.877156515514165 0.207483323815853 no 655 0.190200815662343 232 657714 SGTC_3310 9130229 44.1445 µM 0.876475875548442 0.207670314354259 no 656 0.19038569282587 203 7761258 SGTC_1242 0402-0103 60.1 µM 0.875957850198465 0.207812696881195 no 657 0.19052647412948 210 432868 SGTC_1959 st077091 55.8 µM 0.875663187510271 0.207893712493543 no 658 0.190606581727461 228 821356 YKL052C ASK1 SGTC_3078 9116413 49.47 µM 0.875485536630732 0.207942565471364 no 659 0.190654888245864 240 17177322 SGTC_648 0375-0473 33.3 µM 0.873880346439882 0.208384290836906 no 660 0.191091709396473 226 1713139 SGTC_2714 st079313 56.9 µM 0.870756955628394 0.20924538777427 no 661 0.191943436303995 194 2939799 SGTC_949 1165-0505 146 µM 0.870349922316169 0.209357758062583 no 662 0.192054602334089 220 6244267 SGTC_497 capsazepine 133 µM 0.869677504438206 0.209543471232574 no 663 0.192238334581547 218 2733484 A calcium channel blocker. SGTC_1438 4092-1045 4 µM 0.868621643582016 0.209835281889641 no 664 0.19252705611024 232 1351342 SGTC_1992 st073643 23.3 µM 0.868269948433604 0.20993253368522 no 665 0.192623284763084 218 3161292 SGTC_3038 9091290 49.47 µM 0.867473511104934 0.210152864811013 no 666 0.19284130965371 212 25236843 SGTC_2966 9084041 48.03 µM 0.867111867015985 0.210252956993137 no 667 0.192940359548375 197 17741380 SGTC_1591 genipin 88.4 µM 0.866438097427076 0.210439510753262 no 668 0.193124979652662 215 442424 A DNA cross-linking agent. SGTC_3220 9131269 49.47 µM 0.864780218718941 0.210898958757785 no 669 0.193579715187706 236 17722206 SGTC_778 3456-2434 196 µM 0.86390396401557 0.211142032673621 no 670 0.193820324531746 202 5539063 SGTC_2016 5121758 140 µM 0.863306322922545 0.211307913035226 no 671 0.193984534341177 246 2795203 SGTC_1480 1070-0044 41.2 µM 0.863120381611816 0.211359538192274 no 672 0.194035641465712 217 3124987 SGTC_3258 9138477 49.47 µM 0.861638470000869 0.211771243398207 no 673 0.194443247240348 227 4970355 SGTC_1463 k081-0032 34.1 µM 0.86057714558858 0.212066389102144 no 674 0.194735488875905 206 977755 SGTC_1286 0929-0070 131 µM 0.859115610065874 0.212473223711713 no 675 0.195138367943607 219 1420408 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.857810622797997 0.212836866396841 no 676 0.195498521523138 244 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3053 9095903 49.47 µM 0.857662284548011 0.212878224738722 no 677 0.195539485812397 264 17174018 SGTC_931 2812-0076 566 µM 0.855747323045292 0.213412558129272 no 678 0.196068779082522 219 3450959 SGTC_3239 9133757 49.47 µM 0.855594881232962 0.213455127670225 no 679 0.196110951142409 241 17036923 SGTC_2878 9043973 25.97 µM 0.853687930577702 0.21398806374521 no 680 0.196638961652659 218 6465167 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.85186594962618 0.214497976110659 no 681 0.197144248760114 218 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1853 st056710 91.2 µM 0.850636391632233 0.214842487704432 no 682 0.197485683718058 222 269167 SGTC_539 4859-0462 2.54 µM 0.850611290658337 0.214849524128226 no 683 0.197492657709026 219 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3135 9127742 49.47 µM 0.85043289945258 0.214899535451722 no 684 0.197542225759038 242 3643468 SGTC_2106 5357045 167.29 µM 0.849184293216756 0.215249766896265 no 685 0.197889375883045 211 668842 SGTC_2643 anethole 100 µM 0.847983264126671 0.215586965407757 no 686 0.198223645625308 239 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_208 k072-0098 12.366 µM 0.847906783114339 0.215608448432147 no 687 0.19824494331476 231 5948901 SGTC_1349 flufenamic acid 69 µM 0.846806294897009 0.215917705903394 no 688 0.198551549486155 230 3371 A non-steroidal anti-inflammatory. SGTC_462 ag-879 158 µM 0.845661673624472 0.216239638104266 no 689 0.198870754817667 245 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2984 9022109 38.96 µM 0.845456705800575 0.216297315966679 no 690 0.198927947691362 262 6459207 SGTC_555 4296-0685 37 µM 0.844916489524099 0.216449375270223 no 691 0.199078733575134 241 2908540 YHR072W ERG7 SGTC_2419 paclitaxel 166.5 µM 0.843105522938563 0.216959574615664 no 692 0.199584715094205 231 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1159 4092-0538 61.2 µM 0.841804504113902 0.217326536241445 no 693 0.19994869518452 239 717301 SGTC_858 0438-0351 2.77 µM 0.838046549709742 0.218388504668923 no 694 0.201002280165109 239 2799119 SGTC_2952 9073731 13.78 µM 0.837267274904133 0.218609095199659 no 695 0.20122117483587 242 16457353 SGTC_2009 4012297 12.05 µM 0.837160079486413 0.218639449205994 no 696 0.201251296709262 202 45595307 SGTC_1131 3454-3128 32.3 µM 0.836352891885293 0.218868094507335 no 697 0.20147820294167 211 710982 SGTC_2822 7994718 71.43 µM 0.832449549395959 0.219975700992078 no 698 0.202577621888482 262 1018011 SGTC_2987 9018338 71.43 µM 0.831604610418301 0.220215882327787 no 699 0.202816079445323 245 5055682 SGTC_2314 7727897 200 µM 0.830142198795098 0.220631940875105 no 700 0.203229195385614 206 900724 SGTC_983 1491-0821 12.2 µM 0.828298607768885 0.221157086705909 no 701 0.203750705556426 214 46495113 SGTC_1999 st074831 12.5 µM 0.826243360837123 0.221743364703338 no 702 0.204333027843115 234 17112523 SGTC_2414 st077232 92.9 µM 0.825639611707097 0.221915758248523 no 703 0.204504278884227 205 729801 SGTC_1842 st055362 61.2 µM 0.822656044265677 0.222768804077215 no 704 0.205351809122619 206 676032 SGTC_1026 k007-1105 30.6 µM 0.821814031758459 0.223009885509503 no 705 0.205591373240516 233 7066794 SGTC_125 0133-0007 11.75 µM 0.819809827242731 0.223584318169311 no 706 0.20616226396242 235 26541 SGTC_1632 st005650 90 µM 0.818641015411441 0.223919703857655 no 707 0.206495629395722 222 2759605 SGTC_3022 9087993 49.47 µM 0.815421285412548 0.224845068924098 no 708 0.207415602243724 234 17173644 SGTC_2529 gangaleoidin 93.61 µM 0.815293430901785 0.224881859594195 no 709 0.207452184036029 245 4565183 SGTC_262 fenpropimorph 62.5 µM 0.814793642169508 0.225025708631149 no 710 0.207595220408915 240 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1047 2043-3044 82 µM 0.814237117235225 0.22518594880565 no 711 0.207754562879001 268 669592 SGTC_177 1327-0068 8.361 µM 0.810516753684564 0.226258811616808 no 712 0.208821620016158 243 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3242 9133940 49.47 µM 0.810447301622617 0.226278867329838 no 713 0.208841570585205 226 17248444 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.809683567693643 0.226499477460732 no 714 0.209061032327432 203 6857784 SGTC_3184 9108758 49.47 µM 0.806327070713696 0.227470464475019 no 715 0.210027142762342 251 902885 SGTC_2276 7947513 42.08 µM 0.804779201975793 0.227919029646818 no 716 0.210473552738985 236 2105100 SGTC_1180 1193-0155 285 µM 0.803296405568436 0.228349203472561 no 717 0.210901717504585 244 2921347 SGTC_1993 st073995 70.8 µM 0.802153003010503 0.228681227146299 no 718 0.211232229108197 233 3098394 SGTC_2944 9067346 25.62 µM 0.801884678669404 0.228759182994594 no 719 0.211309834804616 240 6473075 SGTC_3035 9091303 49.47 µM 0.798204762144617 0.229829807475452 no 720 0.212375837180819 242 25237002 SGTC_1215 3852-0577 11.2 µM 0.797809626429754 0.229944933694276 no 721 0.212490487066385 232 2884876 SGTC_736 0958-0254 92.6 µM 0.796419343125566 0.230350261278138 no 722 0.212894169497732 254 6812352 SGTC_1054 3429-0080 167 µM 0.796376908201891 0.230362639169464 no 723 0.212906497930159 242 1162877 SGTC_1920 st075728 45.7 µM 0.795820552691417 0.230524957539668 no 724 0.213068171995305 228 3400306 SGTC_2868 9035608 32.47 µM 0.795775973292125 0.230537966477231 no 725 0.213081129639277 234 6462614 SGTC_2214 7179297 48.276 µM 0.794346029531741 0.230955463103554 no 726 0.213497007174961 236 769744 SGTC_2830 7992007 71.43 µM 0.79406905877595 0.23103637823951 no 727 0.213577614584889 241 1952075 SGTC_2544 sphondin 68.51 µM 0.79240165434365 0.231523833403607 no 728 0.214063257554053 239 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3131 9127911 49.47 µM 0.790870881981587 0.231971849380426 no 729 0.214509670824635 235 45595681 SGTC_2403 6032726 181.2 µM 0.790678215427772 0.232028271891784 no 730 0.214565895755433 235 2881040 SGTC_1697 st025554 27.742 µM 0.790391765765872 0.232112172963277 no 731 0.214649504783072 235 1269519 SGTC_1899 st063254 59.6 µM 0.789015768260349 0.232515437774417 no 732 0.215051395266786 225 3093813 SGTC_482 fipronil 114 µM 0.787697520993504 0.232902142795658 no 733 0.215436827984369 237 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2332 7982454 138.89 µM 0.787258717205373 0.233030944160538 no 734 0.215565215471084 272 2981748 SGTC_2526 patulin 37.61 µM 0.785842306871633 0.233446970581804 no 735 0.21597993879018 250 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1152 3909-8331 15.9 µM 0.785541243175202 0.233535451729967 no 736 0.216068149425808 226 16001939 SGTC_2134 5324836 1.464 µM 0.785038102426236 0.233683363841413 no 737 0.216215614516962 257 699272 SGTC_50 0929-0078 56.389 µM 0.784695827571884 0.233784014657938 no 738 0.21631596485768 217 1377751 SGTC_2227 7312221 64.1025 µM 0.782982449034715 0.234288219134551 no 739 0.216818709300616 266 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2282 7944268 200 µM 0.780979995396636 0.234878253209468 no 740 0.21740713026207 243 2970414 SGTC_2286 7945697 125 µM 0.780710463733907 0.234957734870815 no 741 0.217486402477926 234 1245733 SGTC_1 0258-0098 57.368 µM 0.780297901557415 0.235079423297545 no 742 0.217607773845609 223 6790032 YDR047W HEM12 SGTC_1839 st053978 48 µM 0.779365051742778 0.235354702923911 no 743 0.217882352320773 235 3788398 SGTC_2887 9044784 58.44 µM 0.779149284488682 0.235418400161905 no 744 0.217945890495267 246 6465546 SGTC_1594 piperine 70.1 µM 0.777665639661684 0.235856648519241 no 745 0.218383076787521 237 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_699 0375-0592 111 µM 0.777491082533131 0.235908239856921 no 746 0.218434546806622 210 762578 SGTC_46 0329-0187a 2.197 µM 0.777032148973333 0.236043909913019 no 747 0.21856990155577 249 46494817 SGTC_723 4182-0001 115 µM 0.776459261067405 0.236213327492653 no 748 0.218738932971098 229 744821 YLR208W SEC13 SGTC_2173 5763948 167 µM 0.776116445222218 0.236314738909137 no 749 0.218840117256061 250 2867177 SGTC_1887 st057648 70.8 µM 0.775345498292188 0.236542887153893 no 750 0.219067765517602 263 688672 SGTC_627 1391-0720 175 µM 0.774610433822381 0.236760529439991 no 751 0.219284945026877 274 997839 SGTC_2922 7999257 32.47 µM 0.774586724846028 0.236767551168469 no 752 0.219291952055349 266 2988377 SGTC_2273 7815444 169.05 µM 0.773796754060891 0.237001576985334 no 753 0.219525496171983 255 2824616 SGTC_1789 tunicamycin 25 nM 0.770352284376699 0.238023472100123 no 754 0.220545474816475 265 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_420 mitomycin C 81.9 mM 0.770255655631808 0.238052174416918 no 755 0.220574127686876 232 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1378 2093-0007 380 nM 0.769849500472208 0.238172838287103 no 756 0.220694586299546 272 3618014 SGTC_590 k048-0076 22.4 µM 0.769643202007363 0.238234139940367 no 757 0.22075578529175 255 6832814 SGTC_788 1182-0090 188 µM 0.768805693476311 0.238483094614028 no 758 0.221004334234619 237 5715185 SGTC_1638 st008370 60.6 µM 0.766281968371639 0.239234148288488 no 759 0.221754272504802 246 24207134 SGTC_2349 9023730 187.07 µM 0.766106497047036 0.239286416082711 no 760 0.221806468736476 252 4126287 SGTC_560 2332-1943 155 µM 0.761835669884069 0.24056049284998 no 761 0.223079044193132 259 21177716 SGTC_3072 9116419 49.47 µM 0.761770359423073 0.240580004953211 no 762 0.223098536926974 245 17170162 SGTC_432 NS 1619 61.3 µM 0.760584428206822 0.240934462687405 no 763 0.22345266176869 243 4552 A K+/calcium channel activator. SGTC_3121 9125696 49.47 µM 0.760520141277528 0.240953685236359 no 764 0.223471867292027 280 1235365 SGTC_1833 st055984 71 µM 0.759889615866702 0.241142263963629 no 765 0.223660284592879 240 676288 SGTC_551 k048-0028 34.9 µM 0.759885650323462 0.241143450239602 no 766 0.223661469885538 255 6836383 SGTC_1843 st055809 45.5 µM 0.759369787749983 0.241297795455473 no 767 0.223815690590553 254 16413835 SGTC_3188 9110789 49.47 µM 0.758999456769482 0.241408630955933 no 768 0.223926440873828 253 849217 SGTC_1316 1272-0050 65.9 µM 0.758242392824911 0.24163529690035 no 769 0.224152943451156 262 7340392 SGTC_2726 cimetidine 79.27 µM 0.758201239243944 0.241647621647079 no 770 0.224165259734688 266 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2322 7413319 38.22 µM 0.757353421291491 0.241901603577226 no 771 0.224419076890032 244 1840400 SGTC_701 4424-0219 185 µM 0.757229005946431 0.241938887026208 no 772 0.22445633769618 245 2911779 SGTC_1957 st077035 62.4 µM 0.756149443476274 0.24226252950074 no 773 0.224779800223628 259 705593 SGTC_3036 9090181 49.47 µM 0.754656599670486 0.242710456067172 no 774 0.225227526805957 259 25236586 SGTC_3110 9122132 49.47 µM 0.754516089097478 0.242752639222609 no 775 0.225269694059168 230 918317 SGTC_681 1642-0006 26.6 µM 0.753294330638753 0.243119594681566 no 776 0.225636532438143 286 4446530 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.753061314425599 0.243189615202965 no 777 0.225706534947205 252 2374 Ca(2+)-ATPase inhibitor. SGTC_2336 9001819 198.65 µM 0.752504193515698 0.243357072189775 no 778 0.225873954476491 272 2989602 SGTC_3050 9093513 49.47 µM 0.752221304921487 0.243442125463515 no 779 0.225958991758504 262 25236664 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.751265120509186 0.243729730678529 no 780 0.226246558022068 241 688667 SGTC_303 1348-1668 34.2 µM 0.751081023439543 0.243785125228673 no 781 0.226301947749163 263 5380509 SGTC_2394 5221648 200 µM 0.749099755923127 0.244381715731162 no 782 0.226898541070569 257 788586 SGTC_744 1594-0068 283 µM 0.747558202963113 0.244846445009433 no 783 0.22736334185601 262 668392 SGTC_580 1123-0028 41 µM 0.747341843312485 0.244911708618292 no 784 0.227428620358437 272 1677248 YPR107C YTH1 SGTC_1994 st072947 40.9 µM 0.744267061108326 0.245840209484605 no 785 0.228357462221272 269 5286565 YDL195W SEC31 SGTC_2511 berberine 10.47 µM 0.743914858961027 0.245946685463059 no 786 0.228463992694621 267 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.743153151185268 0.24617704572503 no 787 0.228694481670289 234 6708561 SGTC_909 3448-9333 149 µM 0.742616294668327 0.24633947459968 no 788 0.228857010186486 251 3344074 SGTC_919 tnp00227 403.569 nM 0.742493089869298 0.246376758988237 no 789 0.228894318483221 264 1269246 A methoxyflavone. YNL221C POP1 SGTC_1183 1254-0324 198 µM 0.741774872442932 0.246594167027469 no 790 0.229111873632783 236 5799357 SGTC_725 1497-0963 19 µM 0.740846900850414 0.246875220803614 no 791 0.229393137049457 252 3549977 SGTC_475 α-linolenic acid 10 µM 0.739829638294317 0.247183514923806 no 792 0.229701686338506 251 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_348 k064-0012 10.7 µM 0.736774905984455 0.248110525768913 no 793 0.230629622938567 254 5066323 SGTC_2198 6589944 200 µM 0.736624401460142 0.248156246831454 no 794 0.230675395802367 240 5290268 SGTC_2817 7995342 71.43 µM 0.735118579224955 0.248613940786406 no 795 0.231133640062949 265 18879975 SGTC_207 4185-0010 4.486 µM 0.734796159421948 0.248711998547971 no 796 0.231231823224521 258 3761753 SGTC_1465 k213-0056 144 µM 0.732640481140318 0.249368135350916 no 797 0.231888867095871 265 24048857 YMR208W ERG12 SGTC_1539 benzyladenosine 56 µM 0.731480210832021 0.249721674357974 no 798 0.232242943792577 237 92208 A nucleotide analog. SGTC_652 0437-0092 114 µM 0.73141608388096 0.249741221855761 no 799 0.232262522017973 246 3091274 SGTC_2765 myclobutanil 7.74 µM 0.730176120806918 0.25011935329303 no 800 0.232641268415199 280 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1512 0259-0544 12.2 µM 0.729785982320834 0.250238390281883 no 801 0.23276050707922 247 18476 SGTC_2001 4023502 57.655 µM 0.729257683101128 0.250399630012934 no 802 0.232922026152474 250 108941 YCR052W RSC6 SGTC_2797 7859098 81.82 µM 0.728898922534457 0.250509157032917 no 803 0.233031746968044 257 972681 SGTC_2926 9010726 65.15 µM 0.727068211817036 0.251068454891321 no 804 0.233592085378016 266 2994293 SGTC_1931 st074438 57.1 µM 0.725146924604701 0.251656134352506 no 805 0.234180949790276 289 2787313 SGTC_1472 k841-0093 193 µM 0.724787414154436 0.251766181324987 no 806 0.234291229065228 268 X1472 SGTC_3288 9119690 36.221 µM 0.72456037195348 0.251835692551084 no 807 0.234360888715724 276 17595618 YKL019W RAM2 SGTC_362 0310-0100 9.03 µM 0.723861318833175 0.252049778214946 no 808 0.234575439725279 243 790235 SGTC_255 tunicamycin 200.472 nM 0.723630841516071 0.252120383147788 no 809 0.234646200847004 247 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1897 st060201 15 µM 0.723282263267665 0.252227187200027 no 810 0.234753243727547 270 611878 SGTC_553 k007-0256 45.7 µM 0.722873178507689 0.252352560815206 no 811 0.234878901628157 258 6287000 SGTC_2406 ethylparaben 405.7 µM 0.722687615117119 0.252409441895055 no 812 0.234935913086256 253 8434 A possible steroid mimic. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.720832122467274 0.252978580798238 no 813 0.23550640458238 277 6708784 An antioxidant flavonoid SGTC_2383 9036125 200 µM 0.720586172537734 0.253054072159019 no 814 0.235582081909406 261 79580 SGTC_741 4582-0002 126 µM 0.720361654374816 0.253122995643978 no 815 0.235651176520701 268 2912688 SGTC_994 3910-0338 138 µM 0.719226896480849 0.253471499182477 no 816 0.236000564900427 269 3479481 SGTC_955 1216-0110 33 µM 0.717001760381854 0.254155607757915 no 817 0.236686505224881 265 3619719 SGTC_397 arbidol 50 µM 0.716007075060128 0.254461732397189 no 818 0.236993490132029 263 131410 A RNA synthesis inhibitor. SGTC_1460 k062-0059 9.15 µM 0.715589502194646 0.254590302298141 no 819 0.237122428809824 249 1373085 SGTC_2007 4011539 71.82 µM 0.715261413746343 0.254691343980768 no 820 0.23722376340886 259 45595301 SGTC_1160 4092-0570 10.5 µM 0.714519707620675 0.254919845230705 no 821 0.237452937126063 271 4994975 SGTC_3041 9091929 49.47 µM 0.713587945560799 0.255207049963729 no 822 0.237741006835343 262 25236887 SGTC_2178 5812956 200 µM 0.710057559240532 0.256296783257651 no 823 0.238834221620151 265 5403383 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.709951114976658 0.256329677305234 no 824 0.238867225657288 250 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2824 7998404 51.95 µM 0.709035425914417 0.256612739911635 no 825 0.239151246593468 282 837851 SGTC_2972 9093619 59.92 µM 0.707806373378732 0.25699292680399 no 826 0.239532753977294 242 25236256 SGTC_193 1273-0060 1.558 µM 0.707622819277549 0.257049731340113 no 827 0.239589759089096 265 2847393 YHR072W ERG7 SGTC_2558 carylophyllene oxide 100 µM 0.707486217312515 0.257092009824399 no 828 0.239632187410656 284 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1479 0549-0158 134 µM 0.707239480395007 0.257168384382838 no 829 0.239708833840223 252 5440202 SGTC_2154 5570129 200 µM 0.707158167575754 0.257193556409579 no 830 0.239734095809163 293 673366 SGTC_2857 9024691 58.44 µM 0.705805669253105 0.257612437383815 no 831 0.240154497999296 280 16478292 SGTC_982 1491-0518 27.5 µM 0.705767317832197 0.257624320329073 no 832 0.240166424772925 263 3091256 SGTC_1912 st060209 90.8 µM 0.70527126996628 0.257778043268435 no 833 0.240320718044231 279 688787 SGTC_1288 0973-0013 65.5 µM 0.705152778460331 0.257814770281232 no 834 0.240357582238878 256 4315430 SGTC_1102 cgs 12066b 26.1 µM 0.704916065217996 0.257888148821112 no 835 0.240431235922599 259 6438352 A 5-HT1B full agonist. SGTC_3161 9100388 49.47 µM 0.703571784041644 0.258305066834233 no 836 0.240849744080927 281 25236368 SGTC_779 1360-0071 233 µM 0.702590390932001 0.258609658466488 no 837 0.241155526267954 267 7566 SGTC_3132 9126706 49.47 µM 0.702567982666249 0.258616615414511 no 838 0.241162510692517 281 850858 SGTC_1369 1866-0067 208 µM 0.702249682649202 0.25871544640655 no 839 0.24126173338752 266 3531355 SGTC_145 3737-0113 38.366 µM 0.701239346653496 0.259029281503411 no 840 0.241576829271728 263 6849351 SGTC_726 3448-4391 34.2 µM 0.701158087681684 0.259054531080802 no 841 0.24160218140511 276 1356692 SGTC_78 0336-0123 156.75 µM 0.701135392123529 0.25906158349256 no 842 0.241609262491357 259 6765896 SGTC_3331 9141060 1.957 µM 0.700563016390282 0.259239476195789 no 843 0.241787882788595 257 4906567 YPR165W RHO1 SGTC_2623 humulene 100 µM 0.700015047213954 0.259409842546455 no 844 0.241958953696075 262 6187145 An anti-inflammatory. SGTC_1794 st048918 76.9 µM 0.697501637675225 0.260192014486511 no 845 0.242744457432045 234 672303 SGTC_708 3448-5400 146 µM 0.695740174992501 0.260740904429931 no 846 0.243295780445827 284 3462195 SGTC_3267 9137951 49.47 µM 0.695479552671884 0.260822167604103 no 847 0.243377410478025 293 16643986 SGTC_471 1-acyl-paf 4 µM 0.695245195174166 0.260895252416239 no 848 0.243450826688883 258 16759367 SGTC_2253 7938677 135.83 µM 0.695063580142126 0.260951896637632 no 849 0.243507728711822 249 2301972 SGTC_1985 st071382 65.5 µM 0.695026948801433 0.260963322415212 no 850 0.243519206591583 278 6123237 SGTC_2835 9006588 71.43 µM 0.692826821852655 0.261650041206512 no 851 0.24420911886036 240 2345538 SGTC_2720 fluspirilene 36.88 µM 0.690990664619345 0.262223864366728 no 852 0.244785703846153 274 3396 An atypical antipsychotic. SGTC_914 3820-6779 408 µM 0.687906398694922 0.263189186766895 no 853 0.245755863430604 261 2893481 SGTC_1261 0712-0010 12.7 µM 0.686532718492037 0.263619708713159 no 854 0.246188619734558 277 2840123 SGTC_1648 st011736 69.8 µM 0.686360656359528 0.263673659619415 no 855 0.246242853982292 273 2855514 SGTC_526 4469-0568 170 µM 0.685220470756434 0.264031312546793 no 856 0.246602404046253 268 2901964 SGTC_2018 5133068 143 µM 0.68517093064825 0.264046857868447 no 857 0.246618032567037 289 785362 SGTC_1390 3413-2614 145 µM 0.685025206053137 0.264092587878221 no 858 0.246664007682881 298 3421432 SGTC_1484 3473-2379 286 µM 0.681423973589085 0.265223975457505 no 859 0.247801628861244 278 671917 SGTC_2450 5739737 12.93 µM 0.68092109934179 0.265382157433601 no 860 0.247960708282521 278 2262825 SGTC_3229 9132204 49.47 µM 0.680239263214843 0.265596709336854 no 861 0.248176487579209 273 17682924 SGTC_2635 hydroquinidine 100 µM 0.6801404500442 0.265627809961036 no 862 0.248207767089129 269 442912 An experimental heart treatment. SGTC_441 propafenone 146 µM 0.67814331265476 0.266256787979786 no 863 0.248840415388623 290 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2177 5811945 192 µM 0.67750942578299 0.266456581667389 no 864 0.249041395844153 270 5343475 SGTC_821 1114-0266 29.2 µM 0.677284093984335 0.266527621867274 no 865 0.249112860446651 269 3123235 SGTC_2993 9054257 71.4286 µM 0.676958251222867 0.26663036702709 no 866 0.249216221668518 281 6470217 YGL055W OLE1 SGTC_1197 1601-0112 267 µM 0.676714266537536 0.266707313701846 no 867 0.24929363145888 283 7350313 SGTC_2969 9091408 28.7 µM 0.676041589111107 0.266919517476259 no 868 0.24950712013964 272 4286311 SGTC_1259 0671-0132 43 µM 0.675725321175083 0.267019317275991 no 869 0.249607528150668 265 X1259 SGTC_887 0885-0007 9.62 µM 0.675164493724091 0.267196335276375 no 870 0.24978563111465 276 5719458 SGTC_3204 9114183 49.47 µM 0.674970668082816 0.267257527626831 no 871 0.249847200351572 266 17027248 SGTC_2447 5741742 33.78 µM 0.673590174814022 0.267693565172892 no 872 0.250285950685363 271 1776504 SGTC_756 0508-1999 28.3 µM 0.673320689704695 0.267778725557825 no 873 0.250371646457524 296 6753853 SGTC_613 3914-0030 117 µM 0.671358358679209 0.268399255960278 no 874 0.250996132828399 260 1145395 SGTC_3134 9127454 49.47 µM 0.670955576863029 0.268526713442225 no 875 0.251124414786844 290 24262820 SGTC_1519 esterone 74 µM 0.670756880176181 0.268589600820767 no 876 0.251187710455522 288 698 A steroid. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.67063117206629 0.26862939118235 no 877 0.251227759661976 270 688669 SGTC_1233 0325-0408 14.2 µM 0.669733415171205 0.268913644075111 no 878 0.251513873168614 283 12874 SGTC_2735 sertaconazole 140 nM 0.669651240082173 0.268939670361467 no 879 0.251540070819942 305 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1982 st072467 71.9 µM 0.669436594452698 0.269007658347518 no 880 0.251608507255777 288 3163533 SGTC_1232 0279-0259 161 µM 0.668317364681321 0.269362308789366 no 881 0.251965515635687 278 1560000 SGTC_659 k018-0002 107 µM 0.66799743987329 0.269463726458845 no 882 0.252067613346164 281 6797879 YHR007C ERG11 SGTC_831 k061-1017 217 µM 0.667726408807626 0.269549659554997 no 883 0.252154124654523 291 1240153 SGTC_492 tmb-8 126 µM 0.666347256100028 0.269987146263322 no 884 0.252594583478107 269 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.663752180436369 0.270811303088859 no 885 0.253424468114699 280 15053 SGTC_1911 st060208 74.3 µM 0.663101489229495 0.271018149526024 no 886 0.253632778471453 297 688783 SGTC_1328 1441-0025 69.2 µM 0.663065120677172 0.271029712950204 no 887 0.253644424045366 283 4562601 SGTC_2449 5812982 45.77 µM 0.662638375230778 0.271165415552636 no 888 0.25378109318064 282 776185 SGTC_2160 5660466 132.927 µM 0.66255448759588 0.271192095322856 no 889 0.253807963509856 284 2859134 SGTC_1437 4092-1038 11.6 µM 0.662345812634401 0.271258468349318 no 890 0.253874811363649 292 3977136 SGTC_1490 4089-0339 670 nM 0.661472138694798 0.271536444794596 no 891 0.254154788219513 284 742542 SGTC_1964 st076914 61 µM 0.6613591110333 0.271572417116436 no 892 0.254191020800194 309 24208661 SGTC_128 0906-2981 13.371 µM 0.66059515647762 0.271815616437806 no 893 0.254435988012124 297 6740226 SGTC_1399 3562-5772 25 µM 0.659666110442384 0.272111517379099 no 894 0.254734059548011 287 23847490 SGTC_1429 4049-0205 9.46 µM 0.658669964701834 0.272428967367038 no 895 0.255053862095187 271 22774478 SGTC_1241 0364-0022 50.8 µM 0.658420184371816 0.272508595759876 no 896 0.255134084473669 292 4563895 SGTC_1800 st050079 29.0735 µM 0.658314975305404 0.272542139204926 no 897 0.255167878600015 287 3645560 SGTC_1951 sophoraflavanone G 9.2 µM 0.657763289832276 0.272718064738359 no 898 0.255345123394795 279 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1392 3455-1037 33.9 µM 0.65775751856323 0.272719905420985 no 899 0.255346977920701 269 981132 SGTC_507 nimesulide 162 µM 0.657098513052872 0.272930128494061 no 900 0.255558787477657 285 4495 A COX2 inhibitor. SGTC_1430 4049-0248 69.1 µM 0.656569213473538 0.273099033481633 no 901 0.255728974962658 292 22774488 SGTC_1836 st055642 81 µM 0.656220197601789 0.273210436402977 no 902 0.255841227581651 294 8571 SGTC_2100 5377183 190 µM 0.655956238756096 0.27329470478944 no 903 0.25592614071672 272 2844202 SGTC_1637 st007924 17.4 µM 0.655676279725745 0.273384095271831 no 904 0.256016217031613 272 683336 SGTC_18 0111-0177 500 nM 0.65544211256118 0.273458875600549 no 905 0.25609157259637 283 721752 SGTC_2481 5478948 45.16 µM 0.654779604383672 0.273670499721504 no 906 0.256304831990822 270 77792 SGTC_964 1287-0107 19.4 µM 0.654367628682617 0.27380213742499 no 907 0.256437492396565 272 51516812 YPR165W RHO1 SGTC_2725 haloperidol 53.21 µM 0.653405211521342 0.274109778459622 no 908 0.256747539959879 278 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2710 st078562 53.7235 µM 0.653241463340983 0.274162138306686 no 909 0.25680031168492 296 17250908 SGTC_571 k831-0106 44.2 µM 0.653002252793744 0.274238636754325 no 910 0.25687741308962 302 4783639 SGTC_2722 naftopidil 47.16 µM 0.651081315688488 0.274853325650025 no 911 0.257496998496525 299 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1007 4101-0031 70 µM 0.65029678641676 0.275104565695424 no 912 0.257750266242974 305 1146276 SGTC_513 4245-1575 41.7 µM 0.649180472982625 0.275462252164749 no 913 0.25811086586111 278 719745 SGTC_2181 6316240 54.2555 µM 0.647777609999001 0.275912078306949 no 914 0.258564399435801 289 12779990 SGTC_3113 9123498 49.47 µM 0.647290778526786 0.276068264462293 no 915 0.258721884276631 308 8897275 SGTC_626 0214-0009 33 µM 0.646565518543335 0.276301024159723 no 916 0.258956590267413 295 3437874 SGTC_360 0957-0399 1.01 µM 0.645213880688052 0.276735065799359 no 917 0.259394296083785 289 6752301 YPR165W RHO1 SGTC_783 0848-0141 92.7 µM 0.644857084078709 0.276849697005896 no 918 0.259509902559692 302 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_220 paclitaxel 373.376 µM 0.644582471657483 0.276937940004948 no 919 0.259598898468051 277 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_408 cantharidin 100 µM 0.644540562711892 0.276951408090668 no 920 0.259612481630829 276 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2869 9037858 32.47 µM 0.643965728101868 0.277136172412048 no 921 0.259798829048002 283 27187042 SGTC_2306 7482397 179.52 µM 0.643920999733629 0.277150551609227 no 922 0.259813331792037 310 891448 SGTC_53 0973-0023 39.979 µM 0.641574204176878 0.277905506916954 no 923 0.260574843217367 310 674768 SGTC_2729 fluphenazine 10.66 µM 0.641556197269469 0.277911303549689 no 924 0.260580690715748 289 3372 An atypical antipsychotic. SGTC_481 bay k-8644 50 µM 0.640029998496428 0.278402819020752 no 925 0.261076548407303 300 2303 A calcium channel antagonist. SGTC_355 1311-2252 105 µM 0.639966208350575 0.278423371988698 no 926 0.261097284201707 305 5338538 SGTC_2238 6671620 73.2395 µM 0.638937853516561 0.278754806412533 no 927 0.261431680745815 263 729941 SGTC_3217 9129673 49.47 µM 0.638180198842498 0.278999118124563 no 928 0.261678192664602 295 17248312 SGTC_115 0527-0192 112.043 µM 0.637392491428999 0.2792532309524 no 929 0.261934609006427 314 4233931 SGTC_1802 st050112 57.9 µM 0.633547522887377 0.280495222022902 no 930 0.263188078693693 290 4662563 SGTC_3031 9088762 49.47 µM 0.632332511927989 0.280888246674944 no 931 0.263584811599495 289 205253 SGTC_677 0929-0063 136 µM 0.631147705555067 0.281271757103367 no 932 0.263971975566633 312 1539583 SGTC_64 000l-0018 272.079 µM 0.630190370078775 0.28158182193303 no 933 0.264285019519798 287 6811119 SGTC_2145 5634607 200 µM 0.628069485066173 0.282269327422225 no 934 0.264979211020463 306 308662 SGTC_2557 derrustone 83.84 µM 0.62805584234208 0.282273752457256 no 935 0.264983679447521 317 629853 An antioxidant. SGTC_621 3584-0052 32.1 µM 0.627492525684557 0.282456494075284 no 936 0.265168217033819 308 2273927 SGTC_3296 9122258 64.045 µM 0.626697918895594 0.28271436359712 no 937 0.265428634147559 290 4730474 SGTC_2629 bisabolol 100 µM 0.62632433527784 0.282835639786541 no 938 0.26555111383786 319 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1930 st074634 34.3 µM 0.626310939202041 0.282839989009321 no 939 0.265555506284481 294 684253 YOR116C RPO31 SGTC_2159 5658611 73.75 µM 0.625087320260006 0.28323738936566 no 940 0.265956874729553 314 793844 SGTC_2947 9072639 7.68 µM 0.624574541381605 0.283404006522682 no 941 0.26612516652157 306 16488146 SGTC_1304 1165-0502 251 µM 0.623656294451165 0.283702489704718 no 942 0.266426665841266 286 767425 SGTC_406 estrone 100 µM 0.623270021726362 0.283828095578739 no 943 0.26655354713688 299 5870 A steroid. SGTC_431 k089-0097 107 µM 0.623099540218944 0.28388354021089 no 944 0.26660955592787 292 5499420 SGTC_2727 riluzole 51.77 µM 0.623010305915002 0.283912563391036 no 945 0.266638874708477 310 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_321 4534-3890 65.3 µM 0.622983210375728 0.283921376412072 no 946 0.266647777528636 309 699746 SGTC_932 2857-0803 154 µM 0.622338522879342 0.284131104311824 no 947 0.266859647739955 298 674898 SGTC_257 daunorubicin 18.5 µM 0.620164892632701 0.284838769012675 no 948 0.267574616233816 292 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1681 tripelennamine 100 µM 0.619112540438933 0.285181683191781 no 949 0.267921111269353 276 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3097 9117246 49.47 µM 0.618894887797295 0.285252630930062 no 950 0.267992803262627 277 16423892 SGTC_277 nystatin 15.5 µM 0.618613967699125 0.285344214247611 no 951 0.268085349022598 317 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1738 st035555 74 µM 0.618006907069752 0.285542171105323 no 952 0.268285392799787 311 5331140 SGTC_816 0325-0417 81.3 µM 0.617772606434836 0.285618591855732 no 953 0.268362621615273 296 68101 SGTC_2029 5175081 200 µM 0.617494792056875 0.285709217891855 no 954 0.268454207664319 281 1380876 SGTC_1651 st011928 86.1 µM 0.617078499227173 0.285845042689024 no 955 0.26859147480938 297 720198 SGTC_1963 st076565 50.3 µM 0.616835281477225 0.285924412097971 no 956 0.268671689020517 317 4914280 SGTC_673 1082-0474 110 µM 0.616617567888836 0.285995467602122 no 957 0.268743502062902 309 3098046 SGTC_387 norethindrone acetate 66.7 µM 0.614566475126793 0.286665297389609 no 958 0.269420530024467 304 541197 SGTC_395 anisomycin 6.25 µM 0.61425329694506 0.286767638093542 no 959 0.269523979569837 317 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1391 3442-0225 151 µM 0.614191654048163 0.286787783865645 no 960 0.269544343899988 303 5227075 SGTC_1826 st055655 41.6 µM 0.613293252387375 0.287081470364482 no 961 0.269841227100867 300 676168 SGTC_2992 9074591 71.4286 µM 0.613235775417912 0.287100264367603 no 962 0.269860226343581 310 17741321 SGTC_2291 7917025 104.35 µM 0.611444092159464 0.287686406602211 no 963 0.270452810032852 294 2964612 SGTC_298 1391-0729 10 µM 0.610714493109596 0.287925254021185 no 964 0.270694304759844 301 3237558 SGTC_2495 cafestol 54.53 µM 0.609925787808722 0.288183556206586 no 965 0.270955484506557 308 16667697 An anti-infammatory. SGTC_823 0417-1665 178 µM 0.609188173633238 0.288425224851767 no 966 0.271199859153652 314 3429856 SGTC_1497 4476-2978 41.3 µM 0.609031211755531 0.288476663471246 no 967 0.271251875452871 296 1528379 SGTC_2339 9000433 200 µM 0.608800732728902 0.288552202530738 no 968 0.271328263940727 293 2988954 SGTC_1307 1187-1599 12.2 µM 0.608327399255326 0.288707365886894 no 969 0.271485176155583 308 1538471 SGTC_1075 aripiprazole 15.2 µM 0.607464335719174 0.288990387673284 no 970 0.271771401971428 286 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2242 6630449 61.2675 µM 0.60743811438039 0.288998988399418 no 971 0.271780100348877 304 691249 YDR170C SEC7 SGTC_2734 clemastine 41.6 µM 0.607187145940824 0.289081313354491 no 972 0.271863360856801 332 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2925 9010536 32.5 µM 0.607095536802303 0.289111366566641 no 973 0.271893755980612 269 2994177 SGTC_2308 7584454 197.62 µM 0.60681026914654 0.289204960628951 no 974 0.271988416161369 315 893577 SGTC_926 2268-1401 59.4 µM 0.606402947111336 0.289338624452092 no 975 0.27212360597094 300 2931578 SGTC_2912 7964298 10.93 µM 0.606075287520986 0.289446167892554 no 976 0.272232380126506 300 2975850 SGTC_3089 9117425 49.47 µM 0.605753079874261 0.289551940218938 no 977 0.272339365450741 327 9401657 SGTC_2017 5132927 60.65 µM 0.604497450050772 0.289964303659358 no 978 0.272756482013223 307 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_524 r073-0010 27.8 µM 0.604146038131324 0.290079760718515 no 979 0.272873276769373 321 2772106 SGTC_1558 st069300 45.6 µM 0.60303061473727 0.290446377877738 no 980 0.273244161508215 299 24208000 SGTC_157 1348-1695 65.819 µM 0.602184184389942 0.290724727113469 no 981 0.27352577105449 301 5380510 SGTC_2796 7949634 45.45 µM 0.601024636674768 0.291106247602629 no 982 0.273911788593013 314 2971588 SGTC_776 4476-4378 112 µM 0.600886864014877 0.291151593825575 no 983 0.273957671492799 326 2892008 SGTC_1145 3546-0597 10.2 µM 0.598863794894977 0.291817842335705 no 984 0.27463185824692 303 875334 SGTC_146 3448-8650 53.125 µM 0.597720905314239 0.292194538865306 no 985 0.275013087008144 328 2891488 YIL048W NEO1 SGTC_3098 9119039 49.47 µM 0.597131578914767 0.292388869278593 no 986 0.275209767902336 305 17161528 SGTC_1235 benzylparaben 21.5 µM 0.59707135533012 0.292408731392757 no 987 0.275229870728952 333 7180 SGTC_2552 juarezic acid 87.02 µM 0.596831251340487 0.292487925422658 no 988 0.275310025399953 297 1549512 SGTC_1097 itavastatin 7.23 µM 0.596623600729624 0.292556423320771 no 989 0.275379355320505 305 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3355 9151058 44.0485 µM 0.595400124437202 0.292960163838493 no 990 0.275788021183908 305 17015728 SGTC_1406 3909-7906 11.9 µM 0.59482939134811 0.293148591044822 no 991 0.275978759482905 316 X1406 SGTC_3334 9142812 21.919 µM 0.591609510225398 0.294212684356675 no 992 0.277056052004291 309 45283678 SGTC_770 0389-1121 67.2 µM 0.589523052723803 0.294903159783972 no 993 0.277755226266843 303 6753108 SGTC_1804 st050076 49.1 µM 0.587758269617545 0.295487765188291 no 994 0.278347278903286 299 3895976 SGTC_2092 5303694 80.6725 µM 0.586064481698732 0.296049353318377 no 995 0.278916091815406 306 1963699 SGTC_883 0850-0245 24.6 µM 0.58545659093632 0.296251023464413 no 996 0.27912037331701 295 6823229 YPR165W RHO1 SGTC_1743 st037606 46.3785 µM 0.585184917160056 0.296341172673234 no 997 0.279211692718416 278 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2505 galangin 7.89 µM 0.584794856562682 0.296470628038762 no 998 0.279342831607516 329 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_448 monastrol 171 µM 0.584528814504624 0.296558938342213 no 999 0.279432292461431 316 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2731 amoxapine 43.43 µM 0.582777084693726 0.297140710208448 no 1000 0.280021686550652 331 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1680 diphenhydramine 100 µM 0.581893178785362 0.297434464593196 no 1001 0.280319317698491 306 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_980 1473-0395 201 µM 0.578723199009718 0.298489054346291 no 1002 0.281387979913607 321 768876 SGTC_3256 9138902 49.47 µM 0.578557802165823 0.298544125281794 no 1003 0.281443792351861 338 17228773 SGTC_2779 methotrexate 400 µM 0.578346051357855 0.298614637091353 no 1004 0.281515254527592 319 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3243 9134147 49.47 µM 0.578030134971442 0.298719849519349 no 1005 0.28162188702373 313 24282180 SGTC_1603 st002045 67.8 µM 0.578024530046789 0.298721716329105 no 1006 0.281623779051753 327 5887985 SGTC_3167 9103034 49.47 µM 0.57785741078138 0.298777380508302 no 1007 0.281680195531224 310 5127859 SGTC_3172 9105863 49.47 µM 0.573741125874931 0.300149920344162 no 1008 0.283071497018709 306 2348785 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.57166103050643 0.300844593037989 no 1009 0.283775820052017 313 5106787 A p450 inhibitor. SGTC_3300 9124615 50.48 µM 0.57134722541518 0.300949454921782 no 1010 0.283882147668009 314 24824903 SGTC_1509 1326-1131 80 µM 0.568792612031447 0.301803723281578 no 1011 0.284748444490338 287 768313 SGTC_1283 0922-0125 16.4 µM 0.567303420180101 0.30230221466073 no 1012 0.285254026874138 308 3360884 SGTC_2117 5521686 200 µM 0.56655590547594 0.302552576549895 no 1013 0.285507970121353 310 803312 SGTC_642 0335-0876 158 µM 0.563547123339332 0.303561233522881 no 1014 0.286531190608977 321 6812350 SGTC_1610 st001799 48.1 µM 0.563108009892383 0.303708566353569 no 1015 0.286680668767996 310 621897 SGTC_2893 9048488 25.97 µM 0.561612273631863 0.304210660164592 no 1016 0.287190108106676 325 6467338 SGTC_521 r062-0005 13.8 µM 0.560218620981141 0.304678818683699 no 1017 0.287665163648602 307 2832033 SGTC_1393 3470-5649 58.2 µM 0.559414333089799 0.304949142353188 no 1018 0.287939490829036 301 4108395 SGTC_875 0709-0210 25.7 µM 0.558496503171475 0.305257757947908 no 1019 0.288252695839685 317 6251364 SGTC_991 3996-0057 64.7 µM 0.557052897488164 0.305743443113842 no 1020 0.288745644143671 297 715343 SGTC_2235 salicylic acid 500 µM 0.556519907608878 0.305922848130792 no 1021 0.28892774457318 305 338 A COX inhibitor and kinase inhibitor. SGTC_1645 Cervolide 78 µM 0.556145222069485 0.30604899560433 no 1022 0.28905579134653 340 23173 A fragrance. SGTC_2404 5161160 200 µM 0.555926724411475 0.306122569051817 no 1023 0.289130474067991 327 2831543 SGTC_82 0054-0107 293.755 µM 0.554715153916438 0.306530676003554 no 1024 0.289544754649984 303 3104697 SGTC_2225 6654152 15.4 µM 0.554699524189321 0.306535942310101 no 1025 0.289550100850026 329 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3115 9123671 49.47 µM 0.553682266408582 0.306878784733426 no 1026 0.289898156889003 324 3286988 SGTC_285 1486-1325 46 µM 0.553251951998655 0.307023862796945 no 1027 0.290045448543939 320 22310230 SGTC_1547 harmine 94.2 µM 0.553146074149724 0.307059563546729 no 1028 0.290081694686136 322 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2067 5224629 34.075 µM 0.552650270368769 0.30722676701224 no 1029 0.290251456016366 317 2835000 SGTC_3051 9093778 49.47 µM 0.552366005925417 0.307322649630745 no 1030 0.290348808066069 345 17217378 SGTC_22 0964-0034 14.468 µM 0.552359274230655 0.307324920396309 no 1031 0.290351113655028 330 138402 SGTC_1781 st038725 66.3 µM 0.551685385303274 0.307552277009692 no 1032 0.29058196233447 316 4270275 YIL048W NEO1 SGTC_961 1252-1571 372 µM 0.54608080418569 0.309446008609337 no 1033 0.292505197108389 348 6813498 SGTC_2982 9019404 25.97 µM 0.545442209104792 0.309662106240752 no 1034 0.29272470852018 286 22333232 SGTC_2180 6301957 200 µM 0.545375769303133 0.309684592944157 no 1035 0.292747551007559 327 845462 SGTC_219 mitoxanthrone 164.414 µM 0.545320583162862 0.309703271361583 no 1036 0.292766525033531 328 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1458 k015-0034 6.33 µM 0.543812708324207 0.310213819872896 no 1037 0.293285181386685 330 3598957 SGTC_1082 camptothecin 424.86 nM 0.543675570577426 0.310260271257461 no 1038 0.293332373108565 320 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_111 0083-0039 52.457 µM 0.543365158281328 0.310365425487481 no 1039 0.293439204912509 332 759313 SGTC_1909 st060837 51.5 µM 0.541341969264055 0.311051173721496 no 1040 0.294135948818012 346 678937 SGTC_2388 9080168 200 µM 0.541176164056568 0.311107401576873 no 1041 0.29419308253473 350 15943073 SGTC_1442 4112-3290 3 µM 0.538191948762605 0.312120161301175 no 1042 0.295222268940323 328 704353 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.536746261501652 0.312611299044873 no 1043 0.295721448058685 308 6312947 SGTC_705 1124-0212 310 µM 0.533534370289081 0.313703653097726 no 1044 0.296831862712595 364 9554485 SGTC_838 0109-0203 71.4 µM 0.532970813740923 0.313895485803191 no 1045 0.297026892045807 302 759422 SGTC_1356 1502-0781 85.8 µM 0.532561834050634 0.314034732587774 no 1046 0.297168463841956 320 567702 SGTC_2924 9010168 62.78 µM 0.531047551306383 0.314550536293861 no 1047 0.297692914029702 330 2993929 SGTC_1381 2324-0066 62.1 µM 0.530536696182326 0.314724628457707 no 1048 0.297869936620333 337 10885928 SGTC_2723 salbutamol 83.58 µM 0.53011130358784 0.314869627638875 no 1049 0.298017381171853 334 9884233 β2-adrenoceptor agonist SGTC_1329 1447-1697 50.6 µM 0.529588581859129 0.315047841481673 no 1050 0.298198606331243 324 2840515 SGTC_2104 5389443 200 µM 0.528892072810533 0.315285372323022 no 1051 0.298440160699439 341 2244536 SGTC_2109 5483026 200 µM 0.528116002153404 0.315550126060628 no 1052 0.298709412434194 354 759335 SGTC_1662 st014054 52 µM 0.526002702052508 0.316271550626461 no 1053 0.299443164792803 325 2838777 SGTC_2712 st079126 47.7 µM 0.525517863865684 0.316437160319646 no 1054 0.299611619130807 332 3152970 SGTC_205 1486-1330 71.903 µM 0.525088875642825 0.316583723636497 no 1055 0.299760704503375 335 4118834 SGTC_628 1636-0253 16 µM 0.524679907269821 0.316723474015006 no 1056 0.299902863691805 321 4456143 SGTC_1084 voriconazole 435 nM 0.524497876960889 0.316785684805919 no 1057 0.299966148032663 343 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1888 azatryptophan 97.5 µM 0.52111311387977 0.317943405897226 no 1058 0.301143988017849 307 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1685 st024049 53.0905 µM 0.520309416090583 0.318218564074957 no 1059 0.301423967031988 350 1941139 SGTC_1367 1812-0510 76.9 µM 0.519552613059473 0.318477758855346 no 1060 0.301687716677912 312 1142582 YDR527W RBA50 SGTC_3008 9078912 71.4286 µM 0.519539061101307 0.318482401027609 no 1061 0.301692440548859 343 16648731 SGTC_2374 9071832 200 µM 0.517193194389821 0.319286397718184 no 1062 0.302510651173088 333 17381698 SGTC_2603 homopterocarpin 100 µM 0.516334645481855 0.319580860191321 no 1063 0.302810351365884 330 101795 A weak amylase inhibitor. SGTC_185 k048-0037 25.491 µM 0.516081817087141 0.319667596195089 no 1064 0.302898633430888 314 6827589 SGTC_2855 9016525 58.44 µM 0.513560628731793 0.320533060966483 no 1065 0.303779605978793 342 43811474 SGTC_385 1494-0393 12.4 µM 0.513152501660055 0.320673253383476 no 1066 0.30392232425012 341 3090647 SGTC_1840 st055363 71 µM 0.512362684456526 0.320944629723657 no 1067 0.304198600923603 330 676033 SGTC_3316 9136639 10.545 µM 0.511385942535118 0.321280364573442 no 1068 0.30454041817584 321 4903665 SGTC_2664 lyso-paf C-16 73.48 µM 0.509555027373534 0.321910097281939 no 1069 0.305181618877253 341 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2954 9074818 52.69 µM 0.509131058092355 0.322055992114854 no 1070 0.305330181607687 352 16648742 SGTC_1713 st033146 12.748 µM 0.508574322969127 0.322247615520437 no 1071 0.305525315414482 352 674619 SGTC_1732 st034308 51.822 µM 0.508072203267171 0.322420481299285 no 1072 0.305701354092167 316 830119 SGTC_2521 angolensin 13.4 µM 0.507325461059848 0.32267763478745 no 1073 0.305963238291571 343 821428 A flavenoid. SGTC_544 k015-0020 52.4 µM 0.505980945076749 0.323140855745274 no 1074 0.306435013226987 327 3008304 SGTC_1876 myriocin 605 nM 0.505959716534266 0.323148171736139 no 1075 0.306442464650567 369 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2268 7933382 153.85 µM 0.503124679559425 0.324125823940612 no 1076 0.307438308094773 321 935025 YOR257W CDC31 SGTC_794 k038-0031 316 µM 0.502554503037739 0.324322594098497 no 1077 0.307638761861334 335 6624242 SGTC_517 1365-0151 113 µM 0.501497790741183 0.324687399374152 no 1078 0.308010416140862 335 768657 SGTC_1229 0139-0193 12.2 µM 0.501278230904662 0.324763218407852 no 1079 0.30808766184433 347 3090752 SGTC_2649 anisomycin 9.56 µM 0.49983149007639 0.325262992532856 no 1080 0.308596867726371 335 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_561 1550-0330 72.9 µM 0.499483503798189 0.325383250741371 no 1081 0.308719402603954 340 6812934 SGTC_3232 9132874 49.47 µM 0.499118704941139 0.325509338617607 no 1082 0.308847880489336 324 3784940 SGTC_2318 6029776 164 µM 0.498256725970103 0.325807349517713 no 1083 0.309151552315643 358 818325 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.497968378115226 0.32590706451811 no 1084 0.309253165265645 357 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_732 3970-1727 52.7 µM 0.495605094971692 0.326724791928284 no 1085 0.310086528709763 353 1275699 SGTC_660 4031-1742 102 µM 0.495112398123371 0.326895376663128 no 1086 0.310260391319491 340 6738706 SGTC_1274 0865-0114 173 µM 0.494002330264298 0.327279844190472 no 1087 0.310652266887757 319 870624 SGTC_332 4112-0506 40.9 µM 0.491800696610999 0.32804291315128 no 1088 0.311430122016021 354 2790355 SGTC_1567 st069303 68.4 µM 0.487089502603243 0.329678185973327 no 1089 0.313097452594445 360 5581319 SGTC_1035 k081-0041 55.2 µM 0.48650575347171 0.329881035178454 no 1090 0.313304313541022 351 731709 SGTC_1831 st055328 12 µM 0.485949923480875 0.330074229163678 no 1091 0.313501335497578 333 1103068 SGTC_1441 4106-0040 13 µM 0.485626585989994 0.330186634847147 no 1092 0.313615971623599 337 2904180 SGTC_1768 st044301 37.178 µM 0.484210460865338 0.330679119849886 no 1093 0.314118256806052 370 3931349 SGTC_300 r073-0011 5.04 µM 0.484181501864194 0.330689193967454 no 1094 0.314128531866759 334 2735780 SGTC_1864 st057645 30.4 µM 0.482331361741417 0.331333065732708 no 1095 0.314785285936466 331 688666 SGTC_1905 st060207 84.5 µM 0.482223137139782 0.33137074470279 no 1096 0.314823721167207 336 1948547 SGTC_386 1509-0011 3.07 µM 0.481829864261553 0.331507679114204 no 1097 0.314963406239587 340 3107280 SGTC_2271 7849410 118.62 µM 0.480095100615645 0.33211197828435 no 1098 0.315579885925634 359 972430 SGTC_1273 0849-0096 14.1 µM 0.479997700565318 0.332145920236353 no 1099 0.3156145140405 359 5286025 SGTC_1333 1482-0047 286 µM 0.479597773660355 0.33228530112537 no 1100 0.315756714865667 362 3811116 SGTC_1787 fluconazole 80 µM 0.479427080083875 0.332344797617716 no 1101 0.315817416181819 321 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1350 1495-0454 146 µM 0.479427071127931 0.332344800739486 no 1102 0.315817419366824 358 1069057 SGTC_1252 0493-0875 34.8 µM 0.47914302619853 0.332443816038519 no 1103 0.315918441215102 322 3960963 SGTC_2718 lomofungin 53.02 µM 0.47736033054842 0.33306551316046 no 1104 0.316552778582809 345 5351222 A RNA synthesis inhibitor. SGTC_1507 4075-3230 155 µM 0.476966250297829 0.33320300668951 no 1105 0.3166930772699 361 659771 SGTC_1440 4100-1550 40 µM 0.475764302104592 0.333622501556247 no 1106 0.317121152304958 353 742806 SGTC_2679 rapamycin 1 nM 0.474878197129333 0.333931896504371 no 1107 0.317436896293417 328 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2905 7799065 20.05 µM 0.474855262920066 0.333939905778478 no 1108 0.317445070158762 360 1296806 SGTC_1046 2001-0062 216 µM 0.474695060910946 0.333995854957649 no 1109 0.317502169427773 335 739778 SGTC_869 0564-0080 44.1 µM 0.473739848157603 0.334329531383284 no 1110 0.317842716865684 326 6843321 SGTC_981 1488-1094 54.9 µM 0.472235785696105 0.334855198203466 no 1111 0.318379249661843 337 3449522 SGTC_2043 5101342 149 µM 0.471831505136079 0.334996548698856 no 1112 0.318523530645362 351 678451 SGTC_1238 0333-0287 48.8 µM 0.470375661472749 0.335505755627935 no 1113 0.319043324840101 341 7226 SGTC_1335 1486-0900 202 µM 0.466649934296414 0.336810269111429 no 1114 0.32037517748945 341 X1335 SGTC_1898 st060199 18.6 µM 0.464529831413619 0.33755347340949 no 1115 0.321134095878047 337 688866 SGTC_237 nikkomycin 200 µM 0.464489227615342 0.33756771331074 no 1116 0.321148637841937 350 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_898 1000-0849 28.3 µM 0.460663025785328 0.338910617474092 no 1117 0.322520193033973 362 6751807 SGTC_3295 9122362 53.5725 µM 0.460004815343918 0.339141840508588 no 1118 0.322756382072081 363 4730473 SGTC_3052 9092717 49.47 µM 0.459453936658684 0.339335405509807 no 1119 0.322954111687781 358 25237534 SGTC_3257 9139206 32.98 µM 0.459332384006743 0.339378121785585 no 1120 0.32299774792555 348 4910041 SGTC_907 3448-6986 75.5 µM 0.45836259117527 0.339719002205534 no 1121 0.323345981484237 365 590582 SGTC_1262 0737-0114 49.6 µM 0.458057468040429 0.339826279565916 no 1122 0.323455577241651 361 765919 SGTC_707 0865-0008 204 µM 0.457779609816173 0.339923982222169 no 1123 0.323555393169575 348 723043 SGTC_329 k048-0121 21.3 µM 0.457734646108691 0.339939793719489 no 1124 0.323571546824523 340 6832902 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.457648819499998 0.339969975446367 no 1125 0.323602381802322 358 364106 SGTC_468 gf-109203x 121 µM 0.456427232590536 0.340399668982218 no 1126 0.324041393288405 336 2396 A protein kinase C inhibitor. SGTC_2587 piperic acid 92.2 µM 0.454731289176645 0.340996561120144 no 1127 0.32465128388528 343 5370536 SGTC_1294 1000-1494 117 µM 0.453338673881679 0.341486993884058 no 1128 0.325152444323554 359 712797 YDL207W GLE1 SGTC_3264 9137442 49.47 µM 0.449400277094319 0.342875413322539 no 1129 0.326571465730802 335 17015726 SGTC_216 k038-0035 28.382 µM 0.449165534575187 0.342958235356254 no 1130 0.326656124030451 359 4444231 YPR107C YTH1 SGTC_525 k781-2675 26.7 µM 0.44878926985982 0.343091005099681 no 1131 0.3267918399717 355 3651118 YDL195W SEC31 SGTC_1677 st019204 53.9 µM 0.448315659273204 0.343258152099399 no 1132 0.326962700438437 340 3945625 SGTC_2970 9090938 41.86 µM 0.446713162431687 0.343823933733603 no 1133 0.327541088497053 358 17217104 SGTC_2058 5236698 133 µM 0.44646570487461 0.34391133295408 no 1134 0.327630440127059 344 766665 SGTC_1893 st059353 36.1 µM 0.444768387305789 0.344511030990941 no 1135 0.328243571042239 384 3112488 SGTC_719 2810-4230 27.3 µM 0.444642271022124 0.344555606155074 no 1136 0.328289147186113 360 721079 SGTC_1583 clindamycin 39.6 µM 0.444488046397686 0.344610119004279 no 1137 0.32834488464965 369 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_107 0358-0022 2.6945 µM 0.440974326460112 0.34585296475349 no 1138 0.329615791738912 384 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3263 9137018 49.47 µM 0.440726127852679 0.345940818668766 no 1139 0.32970563946144 361 43844957 SGTC_1600 coumarin 106 71.1 µM 0.440618275898597 0.345978997199422 no 1140 0.329744684857192 388 100336 A hepatotoxic, DNA x-linker. SGTC_2575 plumbagin 510 nM 0.4404875639958 0.34602527002583 no 1141 0.329792008674913 345 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.440153165609744 0.346143659598069 no 1142 0.329913088919721 361 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_47 0149-0135 24.25 µM 0.440119048127533 0.346155739312158 no 1143 0.329925443310125 336 5239155 SGTC_2189 6047310 154.431 µM 0.439222110346263 0.346473367280061 no 1144 0.330250302825064 358 711535 SGTC_435 c-PAF 6.7 µM 0.438685744289519 0.346663359444852 no 1145 0.330444628998112 364 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2277 7947813 106.88 µM 0.43479626218613 0.348042247409815 no 1146 0.331855159136119 383 1246798 SGTC_1006 4099-6547 255 µM 0.434481657649079 0.348153868279416 no 1147 0.331969355831865 361 3146833 SGTC_2761 levamisole 97.89 µM 0.434021580366407 0.348317126184844 no 1148 0.332136385041734 376 26879 An alkaline phosphatase inhibitor. SGTC_2858 9025781 8.96 µM 0.433364016347876 0.348550510825405 no 1149 0.332375168917278 357 4894980 YPL153C RAD53 SGTC_508 roscovitine 141 µM 0.43323096643064 0.348597740287846 no 1150 0.33242349215144 374 160355 A CDKinase inhibitor. SGTC_1625 st003711 30.1 µM 0.433221273209029 0.348601181235871 no 1151 0.332427012802278 354 24207034 YER133W GLC7 SGTC_426 0988-0037 14.6 µM 0.431560330604601 0.349190974622633 no 1152 0.333030497705432 384 5383008 SGTC_1605 st000082 49.1 µM 0.431297024016965 0.349284507130157 no 1153 0.3331262069792 381 1114022 SGTC_663 1486-0733 13.9 µM 0.431197186917155 0.349319973939666 no 1154 0.333162499594644 366 722445 YPR165W RHO1 SGTC_1664 st014217 9.02 µM 0.429780058688072 0.349823545958258 no 1155 0.333677820024149 379 3982782 SGTC_443 clozapine 122 µM 0.428505678473008 0.350276618663927 no 1156 0.334141500110024 390 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1650 st011916 45.8 µM 0.42545691757407 0.351361390142416 no 1157 0.335251810804522 388 242528 SGTC_781 4335-2806 94.4 µM 0.425109606835816 0.351485042904219 no 1158 0.335378387500232 381 845254 SGTC_889 0919-1524 82.7 µM 0.42508333284245 0.351494397852543 no 1159 0.335387963764521 356 3905452 SGTC_620 0109-0052 432 µM 0.424545795705076 0.35168580959059 no 1160 0.335583907117163 365 493037 SGTC_2772 vinpocetine 57.06 µM 0.423573554389167 0.352032110743843 no 1161 0.335938422653665 407 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2287 7945887 168.79 µM 0.421765431872522 0.352676469414448 no 1162 0.336598119830654 376 1245853 SGTC_650 1328-0195 38 µM 0.418564130577067 0.353818349979582 no 1163 0.337767354347344 386 2780821 SGTC_829 1635-0120 117 µM 0.418075039165229 0.353992921446919 no 1164 0.337946127058569 367 285054 SGTC_2910 7948405 25.97 µM 0.417753586311274 0.35410767438003 no 1165 0.338063644430135 382 2971328 SGTC_1015 4130-4525 82 µM 0.417014647082834 0.354371512725279 no 1166 0.338333847119923 363 1363237 SGTC_1260 0700-1617 7.75 µM 0.41600873387208 0.354730786498356 no 1167 0.338701806117789 354 2853078 SGTC_1045 1348-1485 165 µM 0.415892301363997 0.354772380094614 no 1168 0.338744406610753 349 6810614 SGTC_1221 2958-7315 257 µM 0.415629696101332 0.354866197855755 no 1169 0.338840496573314 362 4562705 SGTC_3171 9103192 49.47 µM 0.415245624755897 0.355003426163454 no 1170 0.33898105110897 377 13018434 SGTC_2300 7976697 71.57 µM 0.414856895143161 0.35514233802057 no 1171 0.339123333208939 350 2236109 SGTC_2671 danthron 100 µM 0.414724149910464 0.355189778711623 no 1172 0.339171925632502 365 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2351 9026858 72.31 µM 0.410422927800659 0.356728166830885 no 1173 0.340747865063475 382 1409300 SGTC_3087 9117406 49.47 µM 0.407138037363646 0.357904623751329 no 1174 0.3419533038631 326 42546093 SGTC_1695 st026914 34.495 µM 0.407052055501494 0.357935435649447 no 1175 0.341984877883618 359 3289191 SGTC_1222 0366-0074 1.18 µM 0.406832556374145 0.358014098118813 no 1176 0.342065486754321 390 286520 SGTC_1559 coumarin 343 70.1 µM 0.40654704136194 0.358116427892045 no 1177 0.342170350073238 369 108770 A hepatotoxic, DNA x-linker. SGTC_1357 1503-1303 39.5 µM 0.404814066866023 0.358737751656303 no 1178 0.342807094002038 349 292895 SGTC_250 brefeldin a 552.239 µM 0.403875250793394 0.35907450191017 no 1179 0.343152228337275 389 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1177 0983-0204 23.6 µM 0.40304336071917 0.359372989700178 no 1180 0.343458163149318 371 766818 SGTC_1341 1486-1360 280 µM 0.402230455417394 0.359664748551829 no 1181 0.343757215255579 363 3976547 SGTC_1163 k060-0048 49.9 µM 0.402081119116897 0.359718355561492 no 1182 0.343812163824672 361 6809982 SGTC_2943 9068529 45.32 µM 0.401772901706304 0.359829004591543 no 1183 0.343925583424589 386 3270634 SGTC_1368 1852-0141 284 µM 0.400938867591412 0.360128478964912 no 1184 0.344232566456705 376 2838987 SGTC_1795 st049545 62.3 µM 0.400216471489335 0.360387937177572 no 1185 0.344498541855871 349 5291882 SGTC_2120 5538279 151.968 µM 0.399983380541709 0.360471668633402 no 1186 0.344584378860256 355 2058197 SGTC_1292 0kpi-0043 232 µM 0.399269801016191 0.36072804386257 no 1187 0.344847208123446 385 3333905 SGTC_929 2805-0021 398 µM 0.398565426328445 0.360981173374142 no 1188 0.345106720464793 390 3098024 SGTC_493 zm226600 134 µM 0.397980760045804 0.361191329811409 no 1189 0.345322184057921 397 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3285 9112818 20.8695 µM 0.397784145843828 0.361262011579187 no 1190 0.345394652391287 385 17017947 YPR165W RHO1 SGTC_317 4495-0002 170 µM 0.397772684689262 0.361266131949873 no 1191 0.345398876934276 370 15991618 SGTC_1251 0490-5699 265 µM 0.397448812573214 0.361382573046557 no 1192 0.345518263065907 388 3883818 SGTC_2516 gossypol 71.55 µM 0.396234437608257 0.361819289124906 no 1193 0.345966044197998 375 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2810 7959871 45.46 µM 0.396077457971088 0.361875755622876 no 1194 0.346023943642812 371 2974535 SGTC_1285 0929-0069 65.5 µM 0.395930150971143 0.361928745551301 no 1195 0.346078278763271 355 1206237 SGTC_1767 st044992 70.3 µM 0.395191443777311 0.362194516486336 no 1196 0.346350803366852 377 9600693 SGTC_1037 k284-1091 78.7 µM 0.395103139131553 0.362226291044349 no 1197 0.346383386132749 345 3334711 SGTC_442 cape 100 µM 0.393724726806571 0.362722406492061 no 1198 0.34689214178734 387 5281787 SGTC_3254 9136651 49.47 µM 0.393705070466198 0.362729482832509 no 1199 0.346899398708873 390 16454030 SGTC_2883 9059145 45.46 µM 0.392992337849663 0.362986100326487 no 1200 0.347162570281157 392 16476510 SGTC_2005 4024620 188 µM 0.38932489007576 0.364307525839679 no 1201 0.348517913136596 386 236743 SGTC_1464 k208-0027 110 µM 0.388508443317485 0.364601921695492 no 1202 0.348819903485452 416 X1464 SGTC_1847 st056231 15 µM 0.388176697260557 0.364721566121736 no 1203 0.348942638327714 366 5393180 SGTC_3148 9097893 49.47 µM 0.387287932445231 0.36504216462496 no 1204 0.349271529172078 330 17174100 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.385669419097826 0.365626242954006 no 1205 0.349870756962684 367 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3142 9086498 49.47 µM 0.380577711111381 0.3674657316434 no 1206 0.351758311401707 396 25236367 SGTC_245 methotrexate 289.6 µM 0.378544028008569 0.368201296751221 no 1207 0.352513246555783 378 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3312 9133330 71.43 µM 0.377000898669748 0.368759755656564 no 1208 0.353086468533013 399 17617324 SGTC_1734 st037168 69.4 µM 0.376803690142973 0.368831145477531 no 1209 0.353159749101355 362 708907 SGTC_158 k038-0087 26.446 µM 0.37465518003571 0.36960920256086 no 1210 0.353958464675382 373 X158 SGTC_3067 9117431 49.47 µM 0.373078214011894 0.370180621992561 no 1211 0.354545116362666 399 17150885 SGTC_2721 ifenprodil 61.44 µM 0.372801667804499 0.370280859103832 no 1212 0.354648030733016 382 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3306 9127676 59.7925 µM 0.372221292490376 0.370491250940592 no 1213 0.354864047070402 346 41905287 SGTC_278 4092-0821 23.9 µM 0.370585854878505 0.371084321595691 no 1214 0.355473009615484 382 877900 SGTC_2111 5486399 200 µM 0.369684515447473 0.371411311903845 no 1215 0.35580878529738 381 689674 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.366724462867275 0.372485819476896 no 1216 0.356912278635943 370 5355888 SGTC_1764 st044502 93.5 µM 0.36614651823639 0.372695731196501 no 1217 0.357127873720558 366 8407 SGTC_3163 9099914 49.47 µM 0.36401533634324 0.373470111046105 no 1218 0.357923278582448 420 16268368 SGTC_1901 st060216 58.6 µM 0.363875952301655 0.373520775057223 no 1219 0.357975321372331 376 688792 SGTC_950 1165-0508 94.1 µM 0.362218967127159 0.374123231592906 no 1220 0.358594203424439 389 6148369 SGTC_587 k089-0003 57 µM 0.360711403154852 0.374671627948457 no 1221 0.359157599679373 400 9659696 SGTC_2295 7971645 200 µM 0.360085456149894 0.374899399021755 no 1222 0.359391614312807 409 2978226 YKL099C UTP11 SGTC_837 0091-0265 12.5 µM 0.359998771432771 0.374930945503324 no 1223 0.359424026156427 393 759367 SGTC_349 k015-0014 24 µM 0.35928574626973 0.375190462827809 no 1224 0.359690668142569 374 2196908 SGTC_1119 parthenolide 318.541 nM 0.358994842669379 0.375296358250377 no 1225 0.359799473712811 408 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_253 dyclonine 31.25 µM 0.357620882114468 0.375796637547013 no 1226 0.360313524413603 372 3180 An oral anasthetic. SGTC_1649 st011737 51.3 µM 0.356901714413908 0.376058580438002 no 1227 0.360582693081764 389 1761035 SGTC_2425 5628681 7.85 µM 0.356835236096594 0.376082796761596 no 1228 0.360607577945869 391 5714958 SGTC_1786 berberine 21.6 µM 0.356009628402497 0.376383584821905 no 1229 0.360916677275693 420 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_94 0334-0113 514.748 µM 0.355645231669045 0.37651636691047 no 1230 0.361053132711422 393 6795178 SGTC_2208 7283366 200 µM 0.355456681747569 0.376585078127805 no 1231 0.361123745836252 400 898663 SGTC_2031 5180455 200 µM 0.355405534050449 0.376603718006572 no 1232 0.361142901784862 388 29949 SGTC_1360 1598-0022 39.8 µM 0.353931611325187 0.377140986666909 no 1233 0.3616950680112 418 761525 SGTC_2457 5731572 11.68 µM 0.35357476526521 0.377271098639258 no 1234 0.361828794326374 409 2865357 SGTC_2146 5545642 200 µM 0.353106024092666 0.377442030589483 no 1235 0.362004478424756 394 825326 SGTC_1436 4092-1007 8.32 µM 0.352734407047365 0.377577562155938 no 1236 0.362143781087864 368 2881121 SGTC_2568 diosmetin 100 µM 0.350268502786472 0.37847727740034 no 1237 0.363068600480884 414 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2964 9083345 53.42 µM 0.350103552899594 0.378537484953364 no 1238 0.363130492302635 383 17741579 SGTC_1394 3474-0001 65.7 µM 0.349473812470412 0.378767370537856 no 1239 0.363366813788987 389 5017666 YIL048W NEO1 SGTC_2059 5238311 157 µM 0.349395779299923 0.378795859391925 no 1240 0.363396100771289 380 703021 SGTC_2787 5284540 71.43 µM 0.349230874167078 0.378856066189519 no 1241 0.363457994689424 402 736958 SGTC_313 3474-0040 5.03 µM 0.348969697443453 0.378951427720546 no 1242 0.36355602956021 374 1043375 YIL048W NEO1 SGTC_638 3970-0837 4.09 µM 0.348936081271986 0.378963702280686 no 1243 0.363568648320923 375 4118451 YLR208W SEC13 SGTC_162 k030-0015 37.8 µM 0.345151889707359 0.38034623399904 no 1244 0.364990092600289 410 1809920 YMR134W ERG29 SGTC_3054 9094397 49.47 µM 0.343787787909059 0.380844976506308 no 1245 0.36550294246007 398 2598354 SGTC_2645 abamectin 100 µM 0.343520100677293 0.380942871506728 no 1246 0.365603610835274 393 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1117 retinoic acid 1.10837 µM 0.343487963047807 0.380954624964041 no 1247 0.365615697364659 398 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1396 3511-0007 98.6 µM 0.342783377736295 0.381212335318329 no 1248 0.365880715914656 412 X1396 SGTC_3324 9138759 60.749 µM 0.34218881398275 0.381429844990141 no 1249 0.366104401413032 399 45595710 SGTC_1179 1021-1431 9.29 µM 0.341968514982362 0.381510446640128 no 1250 0.366187293389762 415 2840958 SGTC_2951 9072950 58.06 µM 0.340389303849609 0.382088388998627 no 1251 0.366781686302018 414 16488155 SGTC_2792 7535235 81.82 µM 0.339680814497772 0.382347759645046 no 1252 0.367048455686708 376 1281891 SGTC_3112 9123419 49.47 µM 0.339158851824958 0.382538878580516 no 1253 0.367245032767388 425 17015854 SGTC_1127 asiatic acid 681.4 nM 0.338493798376201 0.382782432283007 no 1254 0.367495549877665 389 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2373 9071805 200 µM 0.338370225524198 0.382827691839493 no 1255 0.367542104403758 401 10149009 SGTC_2342 7990637 118.86 µM 0.334934611358775 0.384086651862881 no 1256 0.368837206215716 411 2033102 YER133W GLC7 SGTC_3283 9109332 35.8195 µM 0.334322415185036 0.384311116320596 no 1257 0.369068138865459 377 17027281 SGTC_804 1595-0054 20.9 µM 0.33431256689267 0.384314727558235 no 1258 0.369071854224986 401 761523 Stimulates phospholipase C. SGTC_975 1335-0046 28.5 µM 0.334164614386369 0.384368980980087 no 1259 0.369127672150699 402 16486740 SGTC_1412 3909-8563 178 µM 0.333213821387583 0.384717685885565 no 1260 0.369486442883871 422 23767530 SGTC_1777 st045864 34.765 µM 0.333176510748693 0.384731371528008 no 1261 0.369500523941566 426 4691462 SGTC_2572 astragaloside iv 100 µM 0.333045728646885 0.384779343887839 no 1262 0.369549882567939 372 45006101 An anti-inflammatory agent. SGTC_3332 9141069 11.198 µM 0.332376818679236 0.385024735229617 no 1263 0.369802370266251 389 17332883 SGTC_2990 9074105 71.4286 µM 0.331359663801355 0.385397969345575 no 1264 0.370186414538049 431 6502001 SGTC_1364 1653-0028 37.6 µM 0.33061962179723 0.385669586593743 no 1265 0.370465911471666 405 5718652 SGTC_1733 st037357 54.9 µM 0.329214582269596 0.38618543174461 no 1266 0.370996750836642 422 1272339 YGL099W LSG1 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.329206131781089 0.386188534860341 no 1267 0.370999944267964 403 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_993 3909-8757 62.7 µM 0.32851825115291 0.386441156870256 no 1268 0.371259923459705 373 4288324 YLR208W SEC13 SGTC_3311 9131146 2.8755 µM 0.328363085206853 0.386498147736664 no 1269 0.37131857536108 398 4900406 YPR165W RHO1 SGTC_2155 5570423 76 µM 0.327733456159535 0.386729429163647 no 1270 0.371556602441456 410 797402 SGTC_2413 inermin 26.06 µM 0.327098319815851 0.386962774348852 no 1271 0.371796761286856 439 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.326193214743173 0.387295374972898 no 1272 0.372139087371621 383 2333 A French combination drug. SGTC_636 0kpi-0074 126 µM 0.324367798386622 0.387966415586512 no 1273 0.372829798038286 398 616434 SGTC_704 1310-0270 142 µM 0.324226789476555 0.388018265768928 no 1274 0.372883170780967 410 5718033 SGTC_947 3447-0010 211 µM 0.324003608598168 0.388100335367084 no 1275 0.372967651107938 415 748350 SGTC_2112 5488546 200 µM 0.32271452239308 0.388574464648597 no 1276 0.373455726428995 412 600757 SGTC_1683 st010134 710 nM 0.322623595486804 0.388607914080437 no 1277 0.3734901609563 395 3818134 SGTC_644 1498-1197 63.3 µM 0.320731358874381 0.389304201402695 no 1278 0.374206990397982 407 6741615 SGTC_3268 9137683 49.47 µM 0.320699124990313 0.38931606560872 no 1279 0.374219205224877 446 1953228 SGTC_2379 9035213 200 µM 0.320471230954064 0.389399948663329 no 1280 0.374305567832873 433 646551 SGTC_1447 4239-0816 81.9 µM 0.319857046492637 0.389626042839599 no 1281 0.374538350258947 385 1341554 SGTC_1852 st056254 31.4 µM 0.317462067816395 0.390508040920427 no 1282 0.375446508739787 422 442583 SGTC_3009 9080819 71.4286 µM 0.315019358675846 0.391408197417186 no 1283 0.376373477768287 396 17027216 SGTC_669 0108-0021 26.2 µM 0.314297618673256 0.39167427555553 no 1284 0.376647503340647 425 17201 SGTC_2680 butyl paraben 22.24 µM 0.313712038138444 0.391890194116369 no 1285 0.376869878454983 414 7184 An antifungal and steroid mimetic. SGTC_223 busulfan 5 mM 0.313467657631708 0.391980313328991 no 1286 0.376962694417293 413 2478 A DNA alkylator. SGTC_1760 st045453 10.4495 µM 0.312719164534341 0.392256368144157 no 1287 0.377247017067499 452 3323419 YIL048W NEO1 SGTC_905 2-aminofluorene 215 µM 0.312453826726825 0.392354241498672 no 1288 0.377347824296067 386 1539 An established DNA mutagen. YPR165W RHO1 SGTC_768 0384-0033 77.3 µM 0.311325513231727 0.392770510806797 no 1289 0.377776586795144 405 3965305 YMR134W ERG29 SGTC_2870 9038528 12.99 µM 0.31024365961847 0.393169754860228 no 1290 0.378187835869255 410 6463316 SGTC_2396 5342950 42.78 µM 0.309770115994336 0.393344545383882 no 1291 0.378367889249296 424 1886677 SGTC_392 N-ethylmaleimide 8.33 µM 0.308828568117205 0.393692145622679 no 1292 0.378725968234336 386 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2440 5628896 157.78 µM 0.306532466978113 0.394540173985804 no 1293 0.379599631851407 405 5522048 SGTC_2507 purpurin 79.67 µM 0.304975416779088 0.395115530436579 no 1294 0.380192437765762 390 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1010 4112-3296 15.2 µM 0.303860961302979 0.39552748117225 no 1295 0.380616910343757 391 704384 SGTC_1263 0774-1208 64.8 µM 0.303618385399105 0.39561716316059 no 1296 0.380709321456302 437 906585 SGTC_2821 7996764 71.43 µM 0.303193874221807 0.395774121174469 no 1297 0.380871058552838 360 2987135 SGTC_273 hydroxyurea 18.1 mM 0.302348947393242 0.39608657320875 no 1298 0.381193034294538 413 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_3149 9097855 49.47 µM 0.30174479219921 0.396310029388481 no 1299 0.381423309791705 441 25236625 YMR079W SEC14 SGTC_1956 st077085 54 µM 0.301541673898858 0.396385163501771 no 1300 0.381500738352486 444 24208685 SGTC_1609 st001574 46.4 µM 0.301134091365447 0.396535941198959 no 1301 0.381656122846044 455 3960012 SGTC_2811 7967822 32.47 µM 0.301131276055156 0.396536982725299 no 1302 0.381657196205602 387 2232244 SGTC_3076 9116187 49.47 µM 0.300622062226492 0.39672537893272 no 1303 0.381851353008682 430 27241210 SGTC_2674 ligustilide 100 µM 0.298638446860055 0.397459495834977 no 1304 0.382607963496726 415 5319022 A signalling regulator. SGTC_2815 7968870 71.43 µM 0.297531824076075 0.397869204314735 no 1305 0.383030257670629 416 2977326 YHR190W ERG9 SGTC_2929 9013348 24.6 µM 0.295968248936824 0.398448283672085 no 1306 0.383627164666785 405 2995952 SGTC_2843 9000894 45.46 µM 0.294889704662206 0.398847859409662 no 1307 0.384039068455446 379 2242070 SGTC_394 menadione 8.33 µM 0.294747413940056 0.398900582761408 no 1308 0.384093420094924 433 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_183 3914-0051 30.55 µM 0.293699899884591 0.399288777590309 no 1309 0.384493615409631 411 1596232 SGTC_315 k915-0449 187 µM 0.292223363247149 0.399836131577351 no 1310 0.385057924785315 425 20970215 YNL149C PGA2 SGTC_1970 st070122 35.8 µM 0.291245704494686 0.400198659308921 no 1311 0.385431704862865 436 102928 SGTC_3305 9127027 53.8275 µM 0.291239874999026 0.400200821214943 no 1312 0.385433933924654 403 41905295 SGTC_2233 sulbentine 40.3845 µM 0.290528611785579 0.400464620690753 no 1313 0.385705932598038 413 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2755 lomerizine 42.69 µM 0.289553561567437 0.400826329555582 no 1314 0.386078899055787 400 3949 A calcium channel blocker. SGTC_1943 st076331 65.2 µM 0.289033696415745 0.401019215768951 no 1315 0.38627779573876 415 24208415 SGTC_491 tetrandrine 80.3 µM 0.287202036638858 0.401699010757781 no 1316 0.386978813485325 432 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2539 epi(13)torulosol 80 µM 0.286914386100152 0.401805795331516 no 1317 0.387088937439925 403 6708597 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.285305962795868 0.402403025570541 no 1318 0.387704872487603 420 688751 SGTC_923 1900-2434 73.3 µM 0.285147650190924 0.40246182161276 no 1319 0.387765512557314 459 5910570 SGTC_1211 1056-0033 32.3 µM 0.284202241443101 0.402812984791063 no 1320 0.388127698919325 416 6741922 SGTC_2168 5727979 200 µM 0.284175274573604 0.402823002532436 no 1321 0.388138031363851 398 695210 SGTC_534 k292-0788 63.4 µM 0.283273119906009 0.403158174643205 no 1322 0.388483740475183 431 4146317 SGTC_2556 citropten 84.59 µM 0.278999971934164 0.404746714499482 no 1323 0.390122423151543 368 2775 A potential DNA crosslinker. SGTC_2773 thioridazine 9.09 µM 0.278698088649709 0.404858999130274 no 1324 0.390238264728271 434 5452 An antipsychotic. SGTC_1207 2099-0101 141 µM 0.277654001114711 0.405247404871592 no 1325 0.390638987192938 420 5837381 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.277087661637242 0.40545812503692 no 1326 0.39085639781811 402 688664 SGTC_258 haloperidol 50.781 µM 0.276595466882752 0.405641280142579 no 1327 0.391045372927919 415 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3058 9093861 49.47 µM 0.276389326451419 0.405717995090417 no 1328 0.391124526909118 435 17217477 SGTC_2385 9074692 200 µM 0.274569179687669 0.406395517647144 no 1329 0.391823623799893 400 17046906 SGTC_1614 st002383 48.6 µM 0.273600280810361 0.40675629031067 no 1330 0.392195909086412 426 1947235 SGTC_1730 st033808 45.1 µM 0.273401420335558 0.406830346457828 no 1331 0.392272330547026 423 1045166 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.273119489432081 0.406935343953573 no 1332 0.392380682834907 410 5377381 SGTC_3260 9137109 49.47 µM 0.271760131170639 0.407441693713246 no 1333 0.392903231266285 432 17478346 SGTC_1059 3448-6867 171 µM 0.270969849935738 0.407736138129258 no 1334 0.393207110644141 433 3934407 SGTC_3116 9124943 49.47 µM 0.270904576899253 0.407760460008219 no 1335 0.393232212380296 388 41905195 YPL160W CDC60 SGTC_871 0574-0004 149 µM 0.270500384107482 0.407911077249286 no 1336 0.39338766072927 416 9551173 SGTC_2665 lovastatin 100 µM 0.26990662440601 0.408132358835205 no 1337 0.39361604535917 425 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2442 5158906 48.48 µM 0.269022119848808 0.408462049150178 no 1338 0.393956330385282 437 1893835 SGTC_2598 perillyl alcohol 100 µM 0.268083701414918 0.408811906170025 no 1339 0.394317445592486 412 10819 An apoptosis inducer. SGTC_1642 st009582 77.7 µM 0.267761656296721 0.408931986372843 no 1340 0.394441393556963 442 6739311 SGTC_98 0074-0023 107.663 µM 0.267707039218432 0.408952352161933 no 1341 0.39446241550947 433 3563821 SGTC_1718 roemerine 11.9335 µM 0.266778422332414 0.409298655341615 no 1342 0.394819884405651 408 235224 An aporphine alkaloid with mutagenic activity. SGTC_1765 st044815 90.4 µM 0.265969769459753 0.409600278783549 no 1343 0.395131245590682 421 645695 SGTC_2900 5328528 85.29 µM 0.265685369188673 0.409706371378671 no 1344 0.395240766114788 447 795359 SGTC_1892 st058411 7.36 µM 0.265349664144796 0.409831611199207 no 1345 0.395370054391643 418 3934738 SGTC_1239 0337-0584 35.4 µM 0.264702130192548 0.410073209465044 no 1346 0.395619468179436 432 914301 YML130C ERO1 SGTC_3320 9137005 35.139 µM 0.263366300639879 0.410571722141576 no 1347 0.39613413108281 446 4908713 SGTC_2785 7756463 72.73 µM 0.261374753688269 0.411315207367307 no 1348 0.396901762079401 438 2201551 SGTC_1384 3089-0840 101 µM 0.261194143316564 0.411382648711845 no 1349 0.396971397179536 400 1069836 SGTC_1981 st071826 47 µM 0.261044318717038 0.41143859639226 no 1350 0.397029165186686 413 11838600 SGTC_1488 4013-0813 75.9 µM 0.260436577043868 0.411665558469181 no 1351 0.397263515854474 420 2910057 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.260264127353222 0.411729965462445 no 1352 0.397330020769706 428 229346 A bile salt which induces apoptosis. SGTC_3278 9139605 49.47 µM 0.259532510330591 0.412003238264823 no 1353 0.397612200740548 424 7958859 SGTC_389 tpck 16.7 µM 0.258573550948475 0.412361492353165 no 1354 0.397982146320747 397 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3037 9091026 49.47 µM 0.258370707116428 0.412437281398134 no 1355 0.398060410805987 426 25236398 YIL048W NEO1 SGTC_1078 idebenone 36.1 µM 0.257910077672228 0.412609399643585 no 1356 0.398238153530803 432 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3032 9089427 49.47 µM 0.256726388282952 0.413051772603439 no 1357 0.398694999605205 448 17173707 SGTC_3043 9092303 49.47 µM 0.255110858838219 0.413655712598001 no 1358 0.399318738726259 399 25236084 SGTC_3014 9081533 49.47 µM 0.254215471957856 0.413990526837627 no 1359 0.399664549132173 454 21367265 SGTC_2777 climbazole 1.536 µM 0.254192743570222 0.413999026534798 no 1360 0.399673328165501 452 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_200 k038-0079 37.545 µM 0.253958329323566 0.414086692388875 no 1361 0.399763875623465 431 3436683 SGTC_954 1189-0853 2.85 µM 0.253909034153172 0.414105128260484 no 1362 0.399782917611204 407 2828194 SGTC_2211 7117706 200 µM 0.2527221311033 0.414549074481928 no 1363 0.400241472378924 450 822771 SGTC_1776 st049249 45.9 µM 0.251360172053322 0.415058632696873 no 1364 0.400767828722973 403 1822314 SGTC_1790 st045711 43.5 µM 0.251109932070104 0.415152272106943 no 1365 0.40086455860078 423 585119 SGTC_1962 st076595 64.5 µM 0.250096300387499 0.4155316207471 no 1366 0.401256438475882 419 279619 SGTC_195 4234-0266 16.654 µM 0.2498224009424 0.415634140326961 no 1367 0.401362347734394 442 2303354 SGTC_45 0kpi-0036 14.9 µM 0.249302652982351 0.415828695906601 no 1368 0.401563339658901 454 2795021 SGTC_2534 helenine 20.12 µM 0.24928391995087 0.415835708567433 no 1369 0.401570584402973 428 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1031 k035-0009 16 µM 0.247911966316806 0.41634936849981 no 1370 0.402101260547492 447 5180959 SGTC_3325 9138760 55.175 µM 0.246044041587907 0.417048949749228 no 1371 0.402824069963686 401 43844959 SGTC_1806 st050005 60.3 µM 0.245942805849997 0.417086872412516 no 1372 0.402863253509932 433 5194765 SGTC_2094 5332512 191.667 µM 0.244542014863955 0.417611684372491 no 1373 0.403405533153606 452 755774 SGTC_3122 9126309 49.47 µM 0.244170783074812 0.417750792493574 no 1374 0.403549277028974 476 17591206 SGTC_714 4296-0578 26.1 µM 0.244059152168726 0.417792624883943 no 1375 0.403592503944917 432 1589775 SGTC_2251 lansoprazole 556 µM 0.243561396263811 0.417979164464664 no 1376 0.403785264647817 444 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2789 5281112 71.43 µM 0.240061115721896 0.41929145252012 no 1377 0.405141439006702 431 765948 SGTC_2030 5175110 200 µM 0.240029047266546 0.419303479460005 no 1378 0.405153869138314 450 2831986 SGTC_1452 4194-0072 190 µM 0.239426835440217 0.419529346717907 no 1379 0.405387311677978 442 1343545 SGTC_2899 9053889 58.44 µM 0.238722981234025 0.419793369853858 no 1380 0.405660197720852 458 6470052 SGTC_616 4092-0450 108 µM 0.237752543500518 0.420157450468122 no 1381 0.406036514036759 430 787165 SGTC_430 0958-0115 16.4 µM 0.237408982836347 0.420286361043922 no 1382 0.406169760811042 423 6833180 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.235382651922957 0.421046852920546 no 1383 0.406955874810088 453 97141 SGTC_558 k064-0027 21.3 µM 0.2353285723402 0.42106715330163 no 1384 0.406976860107117 422 5088526 SGTC_2856 9022925 19.48 µM 0.234997287881735 0.421191515362338 no 1385 0.407105419121919 423 4944862 SGTC_2733 amorolfine 100 µM 0.234744319715642 0.421286483284458 no 1386 0.407203593274836 465 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1009 4106-0057 9.87 µM 0.233599779884268 0.421716217306649 no 1387 0.407647849323309 456 2928005 SGTC_540 1187-0821 17.3 µM 0.232326288806461 0.422194477512938 no 1388 0.40814229772616 476 847520 SGTC_3091 9116372 49.47 µM 0.230830882562276 0.422756224511433 no 1389 0.408723094112772 414 17169793 SGTC_3197 9113331 49.47 µM 0.230727474433951 0.422795075432738 no 1390 0.40876326391485 399 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_203 k066-0004 30.888 µM 0.229990982007605 0.423071800807942 no 1391 0.409049388609455 456 6795412 SGTC_1363 1636-0063 10.4 µM 0.22998693598014 0.423073321143701 no 1392 0.409050960610774 462 6072185 SGTC_1387 3342-1166 1.8 µM 0.226833005549245 0.424258789173709 no 1393 0.410276798924222 431 3418228 SGTC_1723 st034307 2.5525 µM 0.225141212438638 0.424894966758562 no 1394 0.410934710490506 430 867466 SGTC_825 1988-2224 89.6 µM 0.222520795593551 0.425880727315367 no 1395 0.411954243248695 437 1180859 SGTC_548 1436-0017 110 µM 0.221693924514813 0.426191879981189 no 1396 0.412276079986853 455 9677137 SGTC_1856 st057054 55.7 µM 0.221209865146259 0.426374053490209 no 1397 0.412464514125388 456 1266018 SGTC_254 nsc-64875 3.808 µM 0.220023889298021 0.426820456347942 no 1398 0.412926274793787 458 56993 SGTC_900 1112-0045 141 µM 0.219967124727341 0.42684182496183 no 1399 0.412948379152824 474 56211 YIL048W NEO1 SGTC_1249 0481-0015 10.2 µM 0.219468210708875 0.427029646781174 no 1400 0.413142670204934 466 4227577 SGTC_2897 9048598 12.99 µM 0.218637442637481 0.427342435498561 no 1401 0.413466241678878 425 6467404 SGTC_2724 maprotiline 69.64 µM 0.217200106797173 0.427883708069826 no 1402 0.41402620072925 458 4011 A tricyclic antidepressant. SGTC_3085 9117376 49.47 µM 0.216909175194604 0.427993283773076 no 1403 0.414139563529989 472 16480349 SGTC_296 1222-0039 74.9 µM 0.216521141487881 0.428139440395062 no 1404 0.414290773732703 424 5984176 SGTC_2194 5927483 104.545 µM 0.213582911709211 0.429246471427629 no 1405 0.415436163194582 388 760979 SGTC_2601 securinine 100 µM 0.212790847678189 0.429544991456391 no 1406 0.41574505138089 477 442872 A GABA receptor antagonist. SGTC_2133 5320837 200 µM 0.212540463463227 0.429639366841704 no 1407 0.415842706758076 442 2841355 SGTC_1468 k284-1086 134 µM 0.212132105996132 0.429793294487438 no 1408 0.416001986341903 437 15996457 SGTC_3062 9077494 49.47 µM 0.212126818795825 0.429795287532653 no 1409 0.416004048701733 425 16459633 SGTC_1629 st005085 44.9 µM 0.211745605192236 0.429938993240153 no 1410 0.416152753458118 480 24207091 SGTC_2927 9011802 47.9 µM 0.211690053460175 0.429959935295849 no 1411 0.41617442421934 430 43912568 SGTC_1104 tacrolimus 29.8 µM 0.211609158804199 0.42999043155409 no 1412 0.416205981724854 439 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1784 st039334 36.3 µM 0.211026908559544 0.430209944815282 no 1413 0.416433137070748 453 3496984 SGTC_1574 spiramycin 23.7 µM 0.209454309076992 0.430802935730459 no 1414 0.417046800159417 452 6419898 An antibiotic and protein synthesis inhibitor. SGTC_643 k048-0106 28.4 µM 0.208990623053954 0.430977810860609 no 1415 0.417227779355659 464 6763920 SGTC_390 dec-rvkr-cmk 16.7 µM 0.208400090424247 0.431200544668337 no 1416 0.417458292864823 432 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_97 0535-0701 19.132 µM 0.207082845973271 0.431697454330508 no 1417 0.417972579329926 438 2832013 YGL099W LSG1 SGTC_2296 7971656 126.45 µM 0.206893802529539 0.431768776871944 no 1418 0.418046398335891 443 666570 SGTC_2333 9017922 200 µM 0.206683601613706 0.431848084341761 no 1419 0.418128482449462 449 3163164 SGTC_712 r015-0009 80.6 µM 0.205825633717465 0.432171818630305 no 1420 0.418463558537865 446 6813872 YLR060W FRS1 SGTC_1409 3909-8004 61.9 µM 0.205795789377708 0.432183080520787 no 1421 0.41847521519729 428 2119279 SGTC_1557 sumaresinolic acid 42.3 µM 0.205398890360267 0.4323328573148 no 1422 0.418630243579569 424 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.2047553720346 0.432575720880003 no 1423 0.418881628079725 428 165521 SGTC_528 3492-0019 172 µM 0.204707645621747 0.432593733825443 no 1424 0.418900273283533 437 2869262 SGTC_3070 9117005 49.47 µM 0.204701857266178 0.432595918481307 no 1425 0.418902534623828 463 8779016 SGTC_2222 6885208 172.143 µM 0.2046243499456 0.432625171689631 no 1426 0.418932814712729 435 609514 SGTC_2655 perillic acid 100 µM 0.204620917549199 0.432626467170731 no 1427 0.418934155671598 453 5702197 An apoptosis inducer. SGTC_9 0092-0002 10.449 µM 0.204255936018502 0.432764225400141 no 1428 0.419076750990088 450 759368 SGTC_840 0245-0196 390 µM 0.203448786810573 0.433068903910102 no 1429 0.419392135351968 431 3827528 SGTC_3127 9126946 49.47 µM 0.202907537286001 0.433273234280133 no 1430 0.419603651463545 465 27243249 SGTC_3029 9088683 49.47 µM 0.202406256073037 0.433462491884286 no 1431 0.419799568991473 426 25236615 SGTC_2833 9001315 45.46 µM 0.201855481232726 0.43367045328822 no 1432 0.420014853209191 420 2989378 SGTC_1644 st010134 20.9 µM 0.201394350650222 0.433844580965513 no 1433 0.420195116122922 479 3818134 SGTC_859 0439-0102 54.6 µM 0.201369728479365 0.433853878913267 no 1434 0.420204741772777 442 610143 SGTC_1217 1183-1422 255 µM 0.200285571940491 0.434263319762176 no 1435 0.420628622930426 445 2849664 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.199767008909268 0.434459184420941 no 1436 0.420831402146667 430 16486 A toxic proline analog. SGTC_363 0455-0021 3.06 µM 0.196879794704197 0.435549997012506 no 1437 0.421960802850696 461 4597466 SGTC_1570 verbenone 133 µM 0.196006859358905 0.435879895919783 no 1438 0.422302398572767 470 29025 A natural terpanoid with antifungal properties. SGTC_2387 9077560 195.08 µM 0.19127162679057 0.437670202279054 no 1439 0.424156394613514 431 5303272 SGTC_1965 Pectolinarigenin 58.4 µM 0.190301688850614 0.438037077134473 no 1440 0.424536365161587 434 5320438 An anti-inflammatory. SGTC_512 prima-1 270 µM 0.18840527383434 0.438754541559379 no 1441 0.425279482904061 440 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1025 k007-0731 70 µM 0.188249203318065 0.438813596198675 no 1442 0.425340651616488 439 6256118 SGTC_927 2425-1185 123 µM 0.187287952173838 0.439177348559599 no 1443 0.425717434313751 473 730375 SGTC_405 ebelactone b 50 µM 0.186206357619594 0.439586702138501 no 1444 0.426141469246411 458 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_501 nsc-95397 161 µM 0.186205896358291 0.439586876726939 no 1445 0.426141650100363 469 262093 SGTC_2840 9008771 71.43 µM 0.183266392885121 0.440699722577069 no 1446 0.427294501184594 464 2992978 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.181783638558956 0.441261246377339 no 1447 0.427876262560102 434 2724 A muscle relaxant with antifungal properties. SGTC_1354 1498-1681 81 µM 0.181558610365524 0.441346475622335 no 1448 0.427964566521056 448 5754243 SGTC_1011 4112-3381 17.4 µM 0.181482381380648 0.441375347904384 no 1449 0.427994480574675 466 2877139 SGTC_748 act1.228 77.9 µM 0.179654589297091 0.442067730386811 no 1450 0.428711872886902 420 4421505 YNR035C ARC35 SGTC_1380 2291-0730 164 µM 0.179535760738664 0.442112749760811 no 1451 0.428758520232328 431 2999191 SGTC_3159 9100096 49.47 µM 0.179451996157867 0.442144485249588 no 1452 0.428791403458827 443 25236875 SGTC_440 fluspirilene 35.1 µM 0.178840013514654 0.442376355459934 no 1453 0.429031662751796 464 3396 An atypical antipsychotic. SGTC_319 1348-1596 45.5 µM 0.17860127806254 0.442466813773724 no 1454 0.429125395438612 463 5380505 SGTC_1635 st007035 42.4 µM 0.177182112244166 0.443004606084962 no 1455 0.429682672862559 444 3716403 SGTC_2360 9040895 200 µM 0.176150705675946 0.443395523141112 no 1456 0.430087773151586 433 4914414 SGTC_2069 5228469 200 µM 0.174518126171937 0.444014405358958 no 1457 0.430729143361767 463 2835210 SGTC_403 arphamenine a 50 µM 0.174475241380984 0.444030664077189 no 1458 0.4307459934208 484 5487158 An arginine aminopeptidase inhibitor. SGTC_1653 st012112 65 µM 0.17366923851658 0.444336257816483 no 1459 0.431062707106017 470 720429 SGTC_2683 piperine 63.03 µM 0.173404677874736 0.444436572469427 no 1460 0.431166674197476 494 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1692 fluoroquinolonic acid 71 µM 0.173062621198158 0.444566276918704 no 1461 0.431301102764495 471 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2618 avocadyne 43.43 µM 0.171439661809446 0.445181767453435 no 1462 0.431939035391377 469 3015189 SGTC_2591 skatole 100 µM 0.170128313151204 0.445679179457992 no 1463 0.432454613704511 477 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2053 5265679 138 µM 0.169866753859992 0.44577840263371 no 1464 0.432557463834109 464 764595 SGTC_2304 7443016 91.4 µM 0.169470440249955 0.445928751668758 no 1465 0.432713310651713 490 939854 SGTC_276 colchicine 750 µM 0.169038896784117 0.446092474655503 no 1466 0.432883023202004 478 2833 A microtubule depolymerizer. SGTC_1489 4065-0444 182 µM 0.167990019213842 0.446490445879864 no 1467 0.433295565504356 501 2877968 SGTC_787 4152-0075 138 µM 0.167963649478127 0.446500451934541 no 1468 0.433305938131557 458 9566539 SGTC_2224 6650123 117.647 µM 0.167136913813722 0.44681417585809 no 1469 0.433631160741879 483 2908370 SGTC_109 0132-0036 33.701 µM 0.165397675526939 0.447474278400914 no 1470 0.434315491570142 496 67274 A color developer. SGTC_1256 0570-0116 285 µM 0.164567018878851 0.447789593482103 no 1471 0.434642396168981 449 410638 SGTC_3117 9124945 49.47 µM 0.164489179643684 0.447819142745166 no 1472 0.43467303206307 457 17592065 SGTC_2652 actinonin 100 µM 0.163411856912345 0.44822814473575 no 1473 0.435097083950381 477 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1093 fluphenazine 7.97 µM 0.162955104235103 0.44840156600957 no 1474 0.435276891856159 492 6602611 An atypical antipsychotic. SGTC_1352 1496-0991 99 µM 0.161780000694593 0.448847778208328 no 1475 0.43573955134674 500 3000039 SGTC_1942 st076330 65.2 µM 0.160729259387234 0.449246822197765 no 1476 0.436153321690706 482 24208414 SGTC_2102 5377816 72.7585 µM 0.160618507273079 0.449288885943696 no 1477 0.436196938731421 490 1379702 SGTC_2110 5483698 200 µM 0.155545207354036 0.451216333009742 no 1478 0.438195758642275 462 2848765 YHR062C RPP1 SGTC_2885 9057732 51.95 µM 0.155510213106524 0.451229632065451 no 1479 0.438209551497539 464 6471414 SGTC_2756 carbadox 75.1 µM 0.153156683477795 0.452124181729522 no 1480 0.439137358078012 474 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2274 7947094 46.08 µM 0.151485653209715 0.452759469051327 no 1481 0.439796313657416 453 2971028 SGTC_2019 4016004 108 µM 0.151356971760397 0.452808395818426 no 1482 0.439847064956964 459 45595336 SGTC_2038 4100038 30.985 µM 0.150762774179399 0.453034328624936 no 1483 0.440081426224183 478 3596803 SGTC_3030 9087619 49.47 µM 0.150498768488421 0.45313471686276 no 1484 0.440185561138238 499 25236973 SGTC_2172 5754775 163.918 µM 0.150110656433166 0.453282302016627 no 1485 0.440338656316404 492 2263357 SGTC_1404 3909-7820 48.3 µM 0.14909945477116 0.45366685615294 no 1486 0.440737578055806 482 23741373 SGTC_1622 st003707 19.4 µM 0.148791934139774 0.453783813100166 no 1487 0.440858907707087 480 10140899 SGTC_570 0987-0065 62.6 µM 0.148299621128496 0.453971059046779 no 1488 0.441053157174772 492 3104428 SGTC_2162 5663267 200 µM 0.147069257146503 0.454439059369397 no 1489 0.441538677612564 480 6456493 SGTC_1763 st044482 94.5 µM 0.14671903753003 0.454572285927237 no 1490 0.441676895723277 502 88505 SGTC_2080 5212524 12.4 µM 0.145943979482273 0.454867142831117 no 1491 0.441982806326821 479 260183 SGTC_1321 1326-2144 215 µM 0.145682726775284 0.454966537340014 no 1492 0.442085928956756 500 3513030 SGTC_1172 0370-0043 85 µM 0.145655326658704 0.454976961973954 no 1493 0.442096744659136 466 376585 SGTC_3247 9135149 49.47 µM 0.145622544661932 0.454989434235938 no 1494 0.442109684818476 491 8934436 YOR116C RPO31 SGTC_48 0382-0018 55 µM 0.145201645229735 0.455149573873253 no 1495 0.442275833498061 426 762596 SGTC_556 4058-0063 51.5 µM 0.142211048815856 0.456287614665784 no 1496 0.443456652399187 478 6615692 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.141529681544403 0.456546952498014 no 1497 0.443725756775487 476 2346 DNA damaging agent; causes G2/M arrest. SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.141138700719621 0.456695773586935 no 1498 0.443880185444589 499 1241132 A phosphatase inhibitor. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.141038059422095 0.456734082197466 no 1499 0.443919937883143 473 23665772 A membrane-active detergent. SGTC_522 1273-0010 11.6 µM 0.140036401024578 0.457115380355743 no 1500 0.444315614942611 490 5705015 SGTC_913 3487-1245 167 µM 0.138719396620849 0.457616780318242 no 1501 0.444835945003181 484 4016153 SGTC_2642 cholecalciferol 100 µM 0.138022533591149 0.457882112087421 no 1502 0.445111304378082 474 9821465 A vitamin D precursor, similar to steriods. SGTC_631 k072-0230 41.5 µM 0.136836489782076 0.458333743358676 no 1503 0.445580020120295 467 5773147 SGTC_1998 st075797 76.8 µM 0.134620089431762 0.45917786580426 no 1504 0.446456128563274 497 24208315 SGTC_3194 9111903 49.47 µM 0.13457247266557 0.459196002820022 no 1505 0.44647495361116 495 17087251 SGTC_1863 st057641 20.1 µM 0.133118155715144 0.459749986448738 no 1506 0.447049968374409 506 3921635 SGTC_402 epigallocatechin gallate 10 µM 0.132791914802258 0.459874270077866 no 1507 0.447178974391419 488 65064 An antioxidant. SGTC_1749 st037932 54.2 µM 0.132353094726013 0.460041447664015 no 1508 0.447352506596871 474 594497 SGTC_818 4072-2707 53.5 µM 0.132207649471775 0.460096859602743 no 1509 0.447410025415444 462 882871 SGTC_3 0833-0587 95.581 µM 0.131497956398112 0.460367250571045 no 1510 0.44769070154796 473 5382644 SGTC_3299 9121982 43.1275 µM 0.131285198988433 0.46044831409324 no 1511 0.447774849971501 470 17594604 YPL160W CDC60 SGTC_505 gw-5074 63.9 µM 0.130962942766328 0.460571101310269 no 1512 0.447902311126501 493 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2836 9010338 19.48 µM 0.130871208435954 0.460606054940512 no 1513 0.447938595548834 491 2994051 SGTC_3323 9138564 53.9225 µM 0.129243706505329 0.461226234101818 no 1514 0.448582406705112 453 43912313 YNL103W MET4 SGTC_1647 st011722 22.4 µM 0.129037932918092 0.461304653346134 no 1515 0.448663816798496 466 2854783 SGTC_1674 st016616 23.6 µM 0.128964616118019 0.461332594361187 no 1516 0.448692823607071 481 625830 SGTC_1990 st072050 59.8 µM 0.127813642530335 0.461771255051446 no 1517 0.449148226720103 507 17233948 SGTC_202 3594-0513 34.79 µM 0.127658013547681 0.461830572171879 no 1518 0.449209809242512 491 708429 SGTC_3223 9129970 49.47 µM 0.124860890641127 0.462896823492017 no 1519 0.450316840375312 478 17248386 SGTC_3235 9132602 49.47 µM 0.124046993688935 0.463207127957935 no 1520 0.450639033396745 483 4912240 SGTC_1020 4335-0961 93.3 µM 0.123592057176685 0.463380585764921 no 1521 0.450819140861033 485 669075 SGTC_2473 5854593 8.94 µM 0.122409614287182 0.463831459067939 no 1522 0.451287312336518 474 2872951 SGTC_2974 9094440 9.66 µM 0.122385647564548 0.463840598220271 no 1523 0.451296802322999 447 25236134 SGTC_3289 9119912 71.43 µM 0.121378435155707 0.464224692441099 no 1524 0.451695648416515 486 17014829 SGTC_252 miconazole 1.30953 nM 0.12076947485777 0.464456931879974 no 1525 0.451936814315366 488 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1493 4348-0038 111 µM 0.120520277687191 0.464551971803401 no 1526 0.452035508724915 499 800424 SGTC_1128 3448-9350 235 µM 0.120133216299385 0.464699595002531 no 1527 0.452188810061239 450 619386 SGTC_92 0063-0024 660.874 µM 0.118515685902017 0.465316565029877 no 1528 0.452829533567273 500 3594437 SGTC_1928 4'-methoxychalcone 40.3 µM 0.118349550401065 0.465379938369323 no 1529 0.452895348848531 493 641818 SGTC_398 bronopol 33.3 µM 0.118180125511275 0.465444567369276 no 1530 0.452962468567838 499 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1446 4239-0190 62 µM 0.116624845949701 0.466037888347442 no 1531 0.45357867392894 503 1340085 SGTC_675 1309-0189 238 µM 0.115838811386749 0.466337780148981 no 1532 0.453890145256328 461 4246530 SGTC_860 0443-0016 25.1 µM 0.115167538569828 0.466593902618536 no 1533 0.454156163952717 468 5337942 SGTC_2560 caryophyllene 100 µM 0.114829288034909 0.466722966515226 no 1534 0.45429021705311 504 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2397 5161689 200 µM 0.113940255806315 0.467062204989852 no 1535 0.454642576913407 499 2259942 SGTC_2760 etidronate 98.04 µM 0.113843961500167 0.467098950580376 no 1536 0.454680744435656 501 3305 A chelator and antioxidant. SGTC_2634 4'-methoxyflavone 100 µM 0.113370343282657 0.467279685809715 no 1537 0.454868475365589 485 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_604 1000-0114 314 µM 0.112983439181557 0.467427335479427 no 1538 0.455021842377229 491 1572745 SGTC_1206 3978-0017 132 µM 0.112655198160296 0.467552601761459 no 1539 0.455151960870562 496 3873677 SGTC_2108 5365811 200 µM 0.112107475947646 0.467761635572476 no 1540 0.455369094923699 485 780283 SGTC_1950 st077106 7.18 µM 0.111838447220219 0.467864311498354 no 1541 0.455475751132418 446 13831864 SGTC_1838 st055369 84.5 µM 0.111684520047907 0.467923059401941 no 1542 0.455536776871949 462 676036 SGTC_2325 6158266 200 µM 0.111428806048686 0.468020656848598 no 1543 0.455638159185056 484 3623240 SGTC_1111 tnp00062 510.699 nM 0.111311917087801 0.468065270080349 no 1544 0.455684502832176 477 676306 SGTC_1865 st057639 52.2 µM 0.110362431567836 0.468427676834599 no 1545 0.456060973173734 502 688818 SGTC_852 0418-0143 439 µM 0.109085649852181 0.468915049650419 no 1546 0.456567278360453 495 5369229 SGTC_2872 9044037 25.97 µM 0.107501683801646 0.469519745463802 no 1547 0.45719549479227 479 6465195 SGTC_1871 st057448 67.3 µM 0.107243716133496 0.469618234047459 no 1548 0.457297817464725 502 691747 SGTC_672 1441-0018 53.7 µM 0.106816779781516 0.469781236681552 no 1549 0.457467167648733 484 251141 SGTC_169 k015-0017 16.025 µM 0.104720146670808 0.47058179601419 no 1550 0.458298937563848 498 1840002 SGTC_1631 benzylvanillin 81.9 µM 0.104223431171508 0.470771474889254 no 1551 0.458496019922474 470 75506 SGTC_1810 st050138 53 µM 0.103399701695952 0.471086043954751 no 1552 0.458822874445373 516 3444541 SGTC_870 0573-2213 57.6 µM 0.102450494876228 0.471448553164614 no 1553 0.459199552686404 512 3916321 SGTC_1926 methyl fluorone black 53.6 µM 0.101063585752349 0.471978266622798 no 1554 0.459749992179839 497 72721 Reacts with homocysteine. SGTC_1470 k295-0292 231 µM 0.100614636360771 0.472149748173171 no 1555 0.459928188766993 523 5045612 SGTC_3147 9097027 49.47 µM 0.10033787536595 0.472255462895326 no 1556 0.460038044504054 502 25236841 SGTC_2446 5162541 200 µM 0.0998660165739786 0.472435703854954 no 1557 0.460225348141388 493 1549321 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.0998307320929957 0.472449182073577 no 1558 0.460239354618212 495 521171 SGTC_2462 5162487 171.77 µM 0.0997225296402229 0.47249051421767 no 1559 0.4602823068158 505 2259986 SGTC_1165 k072-0275 30.3 µM 0.0997009045227449 0.472498774809675 no 1560 0.460290891208385 511 6153523 YGL055W OLE1 SGTC_2265 7929201 200 µM 0.0991838079156904 0.472696304377545 no 1561 0.460496165436338 506 1265108 SGTC_2490 carminic acid 95.39 µM 0.097538534532007 0.473324838996665 no 1562 0.461149366987089 504 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_279 1273-0055 2.93 µM 0.0970222594715318 0.473522082444354 no 1563 0.461354358669429 502 2847562 SGTC_1361 1608-0041 5.61 µM 0.0969271121715519 0.473558434283546 no 1564 0.461392138887661 510 X1361 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0941647647393279 0.474613907492845 no 1565 0.462489137016676 489 4330530 SGTC_1098 clofazimine 15.1 µM 0.0936920206746128 0.474794557683974 no 1566 0.462676904487269 514 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_29 0299-0004 12.984 µM 0.0932934199506743 0.474946879429977 no 1567 0.462835229702185 522 16871 A napthoquinone isolated from Swertia calycina. SGTC_2213 7173844 200 µM 0.0931361058278617 0.475006996641596 no 1568 0.462897716891106 499 892728 SGTC_1250 0485-0349 40.2 µM 0.0929942485128959 0.475061207559428 no 1569 0.462954065222614 491 6842794 YDL195W SEC31 SGTC_131 0141-0277 33.849 µM 0.0927006241432658 0.475173417877983 no 1570 0.463070700576688 492 1547771 SGTC_194 1486-1323 56.904 µM 0.0926367878491942 0.475197813562547 no 1571 0.463096058459057 513 5178754 SGTC_765 1319-0117 244 µM 0.0925595320715386 0.47522733776266 no 1572 0.463126747203645 475 3487746 YGL099W LSG1 SGTC_634 1611-4317 11.2 µM 0.0918341710411461 0.475504549586865 no 1573 0.463414897100291 497 2843522 SGTC_484 loperamide 105 µM 0.0909857380487191 0.475828810961079 no 1574 0.463751961718337 495 3955 An opioid-receptor agonist. SGTC_1529 apigenin 74 µM 0.0909520327970756 0.475841693054327 no 1575 0.463765352646273 512 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_847 0342-0274 5.54 µM 0.0906827769088918 0.475944603129428 no 1576 0.463872328136821 502 18097 SGTC_2805 7950783 58.44 µM 0.0895967604119899 0.476359696766795 no 1577 0.464303829435412 485 1178958 YDL195W SEC31 SGTC_599 1935-0052 86.5 µM 0.0894716691336497 0.476407510398122 no 1578 0.464353534010148 503 9557311 SGTC_88 0180-0332 8.668 µM 0.0890492796143634 0.476568962823059 no 1579 0.464521373090122 507 3101745 SGTC_2803 7707263 71.43 µM 0.0889309274520694 0.476614201955684 no 1580 0.464568402185139 496 2199229 SGTC_226 1,3-diallylurea 8.28947 mM 0.0888604050842745 0.476641158689328 no 1581 0.464596425593674 488 74537 YKL182W FAS1 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.087709888169953 0.477080951586579 no 1582 0.465053630146345 514 91467 include heat shock SGTC_792 4534-1957 155 µM 0.0876724056967988 0.47709527998873 no 1583 0.465068526106405 500 1717904 SGTC_2971 9092186 9.93 µM 0.0875342433103821 0.477148095495512 no 1584 0.465123433828787 496 25236400 SGTC_2938 9059746 27.26 µM 0.0869173593388893 0.477383917380397 no 1585 0.465368600491289 499 6471769 SGTC_2334 9017922 200 µM 0.0866584963559008 0.477482877667159 no 1586 0.465471483683688 511 3163164 SGTC_1524 corynanthine 62.1 µM 0.0855094410162027 0.477922164742992 no 1587 0.465928195058954 498 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2838 9002687 71.43 µM 0.0846714125324919 0.47824256232714 no 1588 0.46626131191164 497 6457060 SGTC_2266 7929956 200 µM 0.0834380192975069 0.478714142477667 no 1589 0.46675162943295 514 2967153 SGTC_2330 7979373 200 µM 0.0833007745751766 0.47876661898918 no 1590 0.46680619220745 503 1863007 SGTC_1682 st012968 530 nM 0.0830675731373356 0.478855786087993 no 1591 0.466898904797775 478 24207270 SGTC_1154 4088-0362 150 µM 0.0827198001729281 0.478988762817049 no 1592 0.467037170283401 512 6618304 SGTC_857 0438-0306 1.35 µM 0.0815746347847682 0.479426652141958 no 1593 0.467492486281502 506 4686136 SGTC_1945 st075991 56.6 µM 0.0814879350169653 0.47945980549144 no 1594 0.467526959715449 460 1084980 SGTC_147 4466-0538 29.23 µM 0.08038859579764 0.479880196919249 no 1595 0.467964098392677 471 6742687 YHR072W ERG7 SGTC_3196 9111891 49.47 µM 0.0791463169158357 0.480355275918844 no 1596 0.468458121730762 519 18891510 SGTC_2366 9070441 60.58 µM 0.0786442837665151 0.480547274102529 no 1597 0.468657781621799 490 6837235 SGTC_1704 st028805 70.8 µM 0.0781879194501006 0.480721810557737 no 1598 0.468839285740445 512 2876101 SGTC_2128 5255449 168.493 µM 0.077945288417298 0.480814606261872 no 1599 0.468935787010836 505 736008 SGTC_438 sphingosine 6.67 µM 0.0779269923545738 0.480821603743797 no 1600 0.468943063950011 501 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2036 5160441 105 µM 0.0778805706089295 0.480839358154461 no 1601 0.468961527434547 495 134534 YIL048W NEO1 SGTC_3107 9121808 49.47 µM 0.0775871334081595 0.480951586707117 no 1602 0.469078238789744 502 662681 SGTC_3233 9132340 49.47 µM 0.0767588263265393 0.481268390733444 no 1603 0.469407702944459 517 17682950 SGTC_2436 5633522 8.09 µM 0.0762579261216956 0.481459976644494 no 1604 0.469606949210993 504 5724242 SGTC_2261 9010538 184.68 µM 0.0750015171434811 0.481940550708581 no 1605 0.470106752394341 501 6457250 SGTC_1613 st002381 52.1 µM 0.074703779227772 0.482054438772108 no 1606 0.470225200344593 521 551167 SGTC_802 4112-3352 742 µM 0.0723964877467096 0.482937052360144 no 1607 0.471143189917134 469 704594 SGTC_3282 9108498 15.4605 µM 0.0721421412438973 0.483034353316576 no 1608 0.471244394856019 508 16459645 SGTC_671 0560-0003 407 µM 0.0718038007490512 0.483163787971493 no 1609 0.471379024035101 511 3238678 SGTC_366 0181-0206 4.31 µM 0.0712961241087156 0.483358006743843 no 1610 0.471581039947324 488 274874 SGTC_2399 5884133 200 µM 0.0711508680651256 0.483413577195796 no 1611 0.471638841929904 500 722445 SGTC_3349 9149703 23.001 µM 0.0709668044639049 0.483483994676971 no 1612 0.471712087527351 516 4910494 SGTC_1830 st055982 50.3 µM 0.0707155897729327 0.483580103079718 no 1613 0.471812056527821 508 455313 An antimicrobial agent. SGTC_2310 7668677 200 µM 0.0702773276327326 0.483747773398144 no 1614 0.471986463904569 523 2197143 SGTC_740 k014-0057 261 µM 0.0701900650845539 0.483781158645642 no 1615 0.472021190868712 524 4012779 SGTC_2389 9091542 195.52 µM 0.0673106351800768 0.484882844598361 no 1616 0.473167205221386 516 3626624 YOL127W RPL25 SGTC_1689 st020265 53.493 µM 0.0663776259627795 0.485239844294133 no 1617 0.473538591402916 524 5758320 YPR016C TIF6 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.066355506521439 0.485248308057068 no 1618 0.473547396371084 495 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1268 0828-0275 2.46 µM 0.0651598694754867 0.485705815318023 no 1619 0.474023356356236 502 745337 SGTC_2259 7964009 200 µM 0.0641858398809028 0.486078539026331 no 1620 0.474411126141325 489 313134 SGTC_1358 1509-0022 2.48 µM 0.0641416053052194 0.486095466190328 no 1621 0.474428736894893 496 3258434 SGTC_1770 st043884 66.3 µM 0.0637969767263981 0.486227345432459 no 1622 0.474565942789879 525 670149 SGTC_2709 st078560 56 µM 0.0634722911509396 0.486351594450831 no 1623 0.474695211599659 520 17250903 SGTC_1051 3253-3903 78 µM 0.0630754735519379 0.486503448381636 no 1624 0.474853202335109 522 5509239 SGTC_2749 bexarotene 57.39 µM 0.0628891943293629 0.486574734283823 no 1625 0.474927369744181 518 82146 An retinoic acid receptor inhibitor. SGTC_2958 9077254 16.72 µM 0.0627354009562745 0.486633588725236 no 1626 0.474988603508487 514 16457351 SGTC_2056 5235370 200 µM 0.0622146992827494 0.486832855681768 no 1627 0.4751959284159 495 5511916 SGTC_1915 st067105 30.6 µM 0.06197753585435 0.486923616679731 no 1628 0.475290360696985 520 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1778 st046819 58.9 µM 0.0617919972483579 0.486994621645372 no 1629 0.475364238290518 536 671715 SGTC_3249 9135183 49.47 µM 0.061241694600283 0.487205222930734 no 1630 0.475583362270697 517 4902779 SGTC_1200 1643-0193 18.4 µM 0.0592601313971876 0.487963597967103 no 1631 0.476372457907545 524 5403974 SGTC_2825 7998094 58.44 µM 0.0582637198329215 0.488344956776649 no 1632 0.476769282889898 528 2987815 SGTC_2122 5258151 111.688 µM 0.0579849258071717 0.488451662155885 no 1633 0.476880317893051 499 2173356 SGTC_2065 5221596 34.26 µM 0.0575675870408053 0.48861139556935 no 1634 0.477046534316184 512 788581 SGTC_3326 9140064 16.379 µM 0.0565433742054879 0.489003413361327 no 1635 0.477454471577088 519 1868434 SGTC_2903 5923464 63.88 µM 0.0559484873766592 0.489231111387876 no 1636 0.477691421976378 514 2876576 SGTC_1515 3460-0031 42.1 µM 0.0559372984349422 0.489235394084967 no 1637 0.477695878738884 513 2876596 SGTC_633 0437-0093 97.7 µM 0.0555586520390716 0.489380326108966 no 1638 0.477846702245014 524 2831118 SGTC_1752 st044819 83.042 µM 0.0552000813755011 0.489517575168203 no 1639 0.477989532053915 514 441209 YML126C ERG13 SGTC_2888 9058547 12.99 µM 0.053282682372182 0.490251513122977 no 1640 0.478753339032291 513 16476514 SGTC_3138 9097216 49.47 µM 0.0531168393577455 0.490314995749517 no 1641 0.478819407262767 530 25237486 SGTC_52 0329-0193 875 nM 0.0516466486980844 0.490877776843711 no 1642 0.479405124313998 529 3739292 SGTC_2060 5238662 140 µM 0.0507187466485385 0.491232982187169 no 1643 0.479774819104207 522 790130 SGTC_1330 1469-0054 61.8 µM 0.0495241176602372 0.491690302076472 no 1644 0.480250808832422 536 7102664 SGTC_1116 jasmonic acid  1.58368 µM 0.0488196765420686 0.491959976677802 no 1645 0.48053150062861 529 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1121 fusaric acid 630.51 nM 0.0484413935920446 0.492104792724102 no 1646 0.480682235346562 506 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2627 acetyl isogambogic acid 100 µM 0.0482951662368005 0.492160772443347 no 1647 0.480740503422383 515 6857789 A caspase activator and apoptosis inducer. SGTC_1141 3253-0389 52.6 µM 0.0472961528229861 0.492543225411542 no 1648 0.481138597127901 525 5402031 SGTC_2950 9072895 21.46 µM 0.0470290008694214 0.492645500547405 no 1649 0.481245056871625 518 17332245 SGTC_1798 st045719 60.953 µM 0.0469741472448992 0.492666500498434 no 1650 0.481266916143155 532 3980186 SGTC_415 dibenzyl ketone 100 µM 0.0462975874226906 0.492925513716684 no 1651 0.481536531103499 530 7593 SGTC_1700 st030840 7.9285 µM 0.0455669866569397 0.49320521924071 no 1652 0.481827691329244 508 5499307 SGTC_2816 7982706 58.44 µM 0.0443390716228203 0.493675325598621 no 1653 0.482317063816699 527 2981853 SGTC_2704 st078022 71.1 µM 0.043289847302551 0.494077027334246 no 1654 0.482735242157902 522 54697681 SGTC_77 0828-0286 12.516 µM 0.0427040986454849 0.494301287310003 no 1655 0.48296870615271 486 745345 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0423376438708378 0.494441589258585 no 1656 0.483114768353635 532 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_572 0960-0087 17.7 µM 0.0417242988693958 0.494676417852428 no 1657 0.483359241564456 526 6796365 SGTC_2463 5473429 200 µM 0.039792717175878 0.495415965367889 no 1658 0.484129191243017 520 5399405 SGTC_888 0916-0002 6.97 µM 0.039639153577858 0.495474761197356 no 1659 0.484190405957211 500 2802138 YIL048W NEO1 SGTC_102 gallobenzophenone 83.616 µM 0.0392610227987353 0.495619538846703 no 1660 0.484341140970814 527 70837 SGTC_2077 5212015 200 µM 0.0389270500977999 0.495747409855692 no 1661 0.484474275024921 523 780900 SGTC_2862 9027634 71.43 µM 0.0373109677366538 0.496366179185411 no 1662 0.485118530296851 532 5012562 SGTC_3344 9148862 3.898 µM 0.0372764493307318 0.496379395772683 no 1663 0.485132291575361 523 4905352 SGTC_2468 5987765 72.9 µM 0.0371565096310705 0.496425318941173 no 1664 0.485180107467066 515 26772094 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.0355076387807946 0.497056652174407 no 1665 0.485837477675747 530 689007 SGTC_2486 5283202 22.39 µM 0.035168294080949 0.497186584230817 no 1666 0.48597277212117 527 1377751 SGTC_2097 5376186 200 µM 0.0340123007252636 0.497629205924733 no 1667 0.486433670908385 522 742755 SGTC_465 cgp-37157 41 µM 0.0324644819378879 0.49822185928345 no 1668 0.487050820198936 532 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_149 3970-0822 46.1 µM 0.0294686065731204 0.499368977456518 no 1669 0.48824542819404 522 3114250 YBL034C STU1 SGTC_890 0929-0006 47.2 µM 0.0294655832908577 0.499370135073 no 1670 0.488246633785634 512 1378169 SGTC_1820 st053765 18.6 µM 0.029030210198036 0.499536839726056 no 1671 0.488420248244526 524 3690829 SGTC_477 mead ethanolamide 10 µM 0.0289336535867664 0.499573811330096 no 1672 0.488458752584896 534 16061185 SGTC_1560 lithocholic acid 53.1 µM 0.0289124844452698 0.499581917011885 no 1673 0.4884671943188 542 9903 A bile acid which acts as a detergent. SGTC_1052 3253-3998 198 µM 0.0285711093984922 0.499712629821169 no 1674 0.488603327017167 527 5450317 SGTC_2778 tioconazole 65.09 nM 0.0284663938322584 0.499752725511525 no 1675 0.488645085498995 532 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_516 3992-2719 87.3 µM 0.0284028251035816 0.499777066039713 no 1676 0.488670435502418 524 5350887 YDR037W KRS1 SGTC_546 peri-Naphthalide 147 µM 0.0282061642921143 0.499852367661016 no 1677 0.488748860393759 531 223824 A penicillin ester. SGTC_867 0518-0118 155 µM 0.0278805574474413 0.49997704285761 no 1678 0.488878707662375 534 6848158 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.0277606458258314 0.49997704285761 no 1679 0.488926526968802 506 4174840 SGTC_1376 2910-0861 41.3 µM 0.0274826345342889 0.499870592046781 no 1680 0.489037395125295 530 1112859 SGTC_140 0062-0056 502.533 µM 0.0254989743494542 0.49911104722936 no 1681 0.489828483286524 537 3758964 SGTC_2355 9061122 103.12 µM 0.0236112282116491 0.498388230916128 no 1682 0.490581357915579 529 5302957 SGTC_1740 st038286 13.222 µM 0.0231796229444742 0.498222970301564 no 1683 0.490753496387669 539 716786 SGTC_2352 9027995 87.8 µM 0.0226059824221521 0.498003325207588 no 1684 0.490982285882737 533 2997347 SGTC_1792 st045773 43.6 µM 0.0224606638395506 0.497947683287463 no 1685 0.491040244893183 537 2919270 SGTC_2564 betulinic acid 100 µM 0.0219953225623342 0.497769506196123 no 1686 0.491225843345559 525 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2965 9082772 38.63 µM 0.0217098346061495 0.497660194354009 no 1687 0.491339709370677 533 16459634 SGTC_1478 0453-0656 35.7 µM 0.0212771636232684 0.49749452723995 no 1688 0.491512280251973 535 5258496 SGTC_1325 1431-0015 227 µM 0.0207170613390197 0.497280068093768 no 1689 0.491735679480177 517 1103340 SGTC_2345 9052315 157.45 µM 0.0203328579796909 0.497132959834713 no 1690 0.491888922161567 539 6469265 SGTC_3207 9114163 49.47 µM 0.0178120587303451 0.496167777435018 no 1691 0.492894392405478 537 849233 SGTC_1036 k216-0215 33.5 µM 0.0163351645293052 0.495602303237557 no 1692 0.493483502021016 541 622330 SGTC_1033 k072-0102 21.3 µM 0.0151956904776056 0.49516602666239 no 1693 0.493938029883406 542 5965931 SGTC_589 1227-0070 34.1 µM 0.015068174170264 0.495117204156219 no 1694 0.493988895705967 544 2841384 SGTC_1977 st070720 65.3 µM 0.014239188317428 0.494799809964034 no 1695 0.494319577697411 528 682188 SGTC_2930 9013230 14.89 µM 0.014048131060943 0.494726660244422 no 1696 0.494395790891541 538 2995857 SGTC_1919 st067113 52.3 µM 0.0137151781793369 0.494599183648432 no 1697 0.494528607075303 543 1268243 SGTC_286 k060-0067 22.9 µM 0.0132250376115334 0.494411526117213 no 1698 0.494724127130427 540 5985051 SGTC_806 3966-4455 5.86 µM 0.0131338809304073 0.494376625575169 no 1699 0.494760490226418 520 714982 SGTC_532 1548-0774 215 µM 0.0124427879713342 0.494112032906737 no 1700 0.495036173878214 534 5932993 SGTC_569 4130-2812 160 µM 0.0124294434333793 0.494106923826255 no 1701 0.495041497166959 540 743552 SGTC_10 0279-0212 42.575 µM 0.012077073317328 0.493972016002059 no 1702 0.495182061951116 535 39851 YBR002C RER2 SGTC_3248 9135562 49.47 µM 0.0117435245092908 0.493844314706808 no 1703 0.495315119234833 538 17650701 SGTC_1299 1079-1439 3.74 µM 0.0114730681609803 0.493740769225962 no 1704 0.495423008437431 535 323161 SGTC_414 piperonyl butoxide 100 µM 0.0108698869941223 0.493509840017932 no 1705 0.495663627888633 538 5794 A potent inhibitor of cytochrome P450. SGTC_87 0100-0052 35.5 µM 0.0106020551569838 0.493407300715312 no 1706 0.495770471174572 540 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1287 0971-0001 34.6 µM 0.0105465028885777 0.493386032607783 no 1707 0.495792632084209 542 4665869 SGTC_1191 1487-1166 10.6 µM 0.0104553480810235 0.493351134159169 no 1708 0.495828995586045 546 3955771 SGTC_424 splitomicin 100 mM 0.00972354099558441 0.493070965043816 no 1709 0.496120929507649 538 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1526 st051518 75 µM 0.00951838823075765 0.492992423819997 no 1710 0.496202769831557 539 673993 SGTC_3026 9090633 49.47 µM 0.00855583677433783 0.492623921767423 no 1711 0.496586756609456 544 25236842 SGTC_2985 9022375 71.43 µM 0.00829353250587318 0.492523502592047 no 1712 0.496691397158663 534 4939335 SGTC_2193 5925765 200 µM 0.00783733374511602 0.492348855009657 no 1713 0.496873388211552 542 877370 SGTC_2884 9058502 51.95 µM 0.00768805073826958 0.492291704982245 no 1714 0.496932941720317 539 6471554 SGTC_37 0566-0070 1.56 µM 0.00758660776971464 0.492252869651367 no 1715 0.496973410429243 546 1626686 SGTC_2678 equilin 100 µM 0.00575077195021699 0.491550071138019 no 1716 0.497705786569585 543 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1148 3909-7663 27.7 µM 0.00510932986419379 0.49130451900735 no 1717 0.49796168116113 543 4084526 SGTC_354 2783-3500 4.88 µM 0.00446039030079317 0.491056100101315 no 1718 0.498220567622248 546 6740761 SGTC_1431 4049-0260 9.09 µM 0.00420232031383308 0.490957309943809 no 1719 0.498323521685317 545 3854841 SGTC_2506 ethyl hematommate 54.16 µM 0.00411784364875791 0.490924972080254 no 1720 0.498357222707092 540 3940691 An allergen. SGTC_1187 1391-0724 117 µM 0.00401024297900773 0.490883782380416 no 1721 0.498400148809139 544 6997986 SGTC_159 3970-0959 50 µM 0.00400578613996592 0.490882076297754 no 1722 0.498401926816389 541 6615653 SGTC_2137 5261020 140 µM 0.00228689196372657 0.490224094540125 no 1723 0.499087662900194 545 763655 SGTC_411 enrofloxacin 100 µM 0.00214075795112218 0.490168156571367 no 1724 0.499145961793513 547 71188 A bacterial gyrase inhibitor. SGTC_2957 9076800 11.52 µM 0.00129673740425249 0.489845081633537 no 1725 0.499482676767848 547 16459615 SGTC_1032 k061-1018 98.7 µM 0.000617060403357787 0.489584919097756 no 1726 0.499753828531161 547 4005393 SGTC_357 1325-0123 420 µM 0.000336578351725177 0.489477559207538 no 1727 0.499865724667364 548 1098503 SGTC_609 0986-0026 86.3 µM -0.000243193839774406 0.489255642695701 no 1728 0.499902979695937 548 2848610 SGTC_895 0964-0006 13.7 µM -0.000365787824382057 0.489208718430998 no 1729 0.499854071774452 546 6738897 SGTC_123 0083-0120 66.675 µM -0.000408937664194512 0.489192202366536 no 1730 0.499836857480251 548 16001701 SGTC_583 1488-1091 88.9 µM -0.0005840289669518 0.489125184481027 no 1731 0.499767006165349 549 4303273 SGTC_1175 0741-0056 27.6 µM -0.000782900508641923 0.48904906485215 no 1732 0.499687667917661 548 765927 SGTC_1318 1280-3875 124 µM -0.000853120748970748 0.489022187604321 no 1733 0.499659654104233 549 373245 SGTC_1073 triclabendazole 3.09 µM -0.00091210778081671 0.488999609977682 no 1734 0.499636121692403 550 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3193 9111931 49.47 µM -0.00156889456618123 0.488748223445503 no 1735 0.499374101880826 549 17087244 SGTC_1908 st060353 56.5 µM -0.00193096681975535 0.488609641429083 no 1736 0.499229656172269 549 4227716 SGTC_59 0330-0160 1.33 µM -0.00200282963929752 0.488582136323922 no 1737 0.499200987110627 549 4293482 SGTC_1627 st003713 25.6 µM -0.00412682388956227 0.487769214105989 no 1738 0.498353640139788 551 16195070 YER133W GLC7 SGTC_333 3486-0131 40.1 µM -0.00534061617167379 0.48730467861479 no 1739 0.497869412533895 551 6744690 SGTC_645 0845-0943 5.41 µM -0.00538339854463148 0.487288305505501 no 1740 0.497852345081824 551 1885106 SGTC_1895 st058434 18.3 µM -0.0054206554374677 0.487274047053028 no 1741 0.497837481948905 554 5393175 SGTC_2245 6637752 200 µM -0.0063454323064271 0.486920134257799 no 1742 0.497468555753447 559 681890 SGTC_2143 5623677 140.463 µM -0.0072874401138195 0.486559637761969 no 1743 0.497092757755107 553 5375313 SGTC_1735 st034310 56.75 µM -0.00757664985869106 0.486448962419488 no 1744 0.496977382946801 552 871153 SGTC_2923 7992654 58.14 µM -0.00763495060971281 0.486426651901873 no 1745 0.496954124984968 553 2985126 SGTC_2141 5621638 7.665 µM -0.00777437169035789 0.486373298448106 no 1746 0.49689850567202 553 2856238 SGTC_1173 0443-0020 122 µM -0.00791795988670995 0.486318350583603 no 1747 0.4968412240328 551 5331295 SGTC_1927 st060202 13.8 µM -0.0083047565272849 0.486170333797015 no 1748 0.496686919576167 553 688887 SGTC_2210 7115885 190.385 µM -0.00885604737034277 0.485959372752182 no 1749 0.496466994448813 553 2927039 SGTC_3005 9076496 71.4286 µM -0.00988752101547729 0.485564671992825 no 1750 0.496055514089516 551 21368410 SGTC_3130 9127414 49.47 µM -0.0123533499963461 0.484621162956026 no 1751 0.495071851725734 557 1494646 SGTC_364 0083-0097 67.7 µM -0.0126670634556309 0.484501131707091 no 1752 0.494946707956621 555 5207356 SGTC_511 blebbistatin 171 µM -0.0137330212183856 0.484093291604975 no 1753 0.494521489402958 559 3476986 A myosin inhibitor. SGTC_2280 7785178 200 µM -0.0141767534633295 0.483923522588382 no 1754 0.494344483086569 554 2954328 SGTC_1021 4476-0760 85.3 µM -0.0143470927789137 0.483858352667417 no 1755 0.494276534442462 562 746768 SGTC_2781 5567276 71.43 µM -0.0146702820577737 0.48373470524314 no 1756 0.494147614144818 558 2853274 SGTC_347 4534-1311 26.2 µM -0.0160282738883056 0.483215174944663 no 1757 0.493605917644495 555 2862016 SGTC_1953 st076800 12.1 µM -0.0171758827840606 0.482776153548395 no 1758 0.493148151050953 551 297591 SGTC_801 0866-0028 10.1 µM -0.0201473707291578 0.481639499829806 no 1759 0.491962905712489 555 6849771 SGTC_2916 7875993 68.79 µM -0.0203201004098158 0.481573431764225 no 1760 0.491894010644283 557 1299250 SGTC_2082 5219693 150 µM -0.0207835312854556 0.481396174742697 no 1761 0.491709167516479 556 2834649 SGTC_3218 9131285 49.47 µM -0.0215924391698436 0.481086785541302 no 1762 0.491386532397777 564 17156417 SGTC_2675 theaflavin digallate 100 µM -0.0222636848240372 0.480830057709396 no 1763 0.491118808504712 556 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1944 st076371 56.9 µM -0.022417615816739 0.480771185640573 no 1764 0.491057414246511 551 24208455 SGTC_1868 st057644 42.7 µM -0.0226605842069504 0.480678261401652 no 1765 0.490960508500813 556 688665 SGTC_272 doxorubicin 8.13 µM -0.0228081905352815 0.480621809279531 no 1766 0.490901637311464 565 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1511 0906-3109 28.5 µM -0.0236590191181641 0.480296417027483 no 1767 0.490562297426873 560 2882180 SGTC_3240 9133527 49.47 µM -0.0254282136075003 0.479619845723513 no 1768 0.489856703587847 579 17617455 SGTC_1000 4048-0884 8.67 µM -0.0259652967661313 0.4794144671402 no 1769 0.489642509140811 567 13040088 SGTC_2188 6126565 140.678 µM -0.026555202064932 0.479188895868844 no 1770 0.489407252109789 554 874518 SGTC_172 1112-0046 2.638 µM -0.0272196926638486 0.478934812241608 no 1771 0.489142254525131 567 2802135 YIL048W NEO1 SGTC_2320 7373003 200 µM -0.0273001313392244 0.478904055198792 no 1772 0.489110176057567 561 5415828 SGTC_582 0987-0078 156 µM -0.0274192291894838 0.478858516419079 no 1773 0.489062680669335 559 1625765 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.0275738772093658 0.478799384931536 no 1774 0.489001008354091 570 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1467 k284-1082 293 µM -0.0276052136619342 0.478787403127503 no 1775 0.48898851167528 569 3334705 SGTC_1573 oleylamine 1.06 µM -0.0276646234973773 0.478764687239195 no 1776 0.488964819628455 563 5356789 An amine of the fatty acid oleic acid. SGTC_127 0180-0333 59.125 µM -0.0280877402753123 0.478602906708852 no 1777 0.488796086030066 555 771601 SGTC_2813 7971799 71.43 µM -0.0297381994070205 0.477971880462773 no 1778 0.488137923331312 567 2234054 SGTC_623 k072-0108 16.9 µM -0.0298376811517722 0.477933846981932 no 1779 0.488098253461085 573 5382803 SGTC_2369 9071472 200 µM -0.0303981817561451 0.477719562296696 no 1780 0.487874747467729 563 17296037 SGTC_1694 st024011 44.9 µM -0.0309413174040775 0.477511922543127 no 1781 0.487658169580606 577 2787533 SGTC_3151 9099821 49.47 µM -0.0317179287817984 0.477215036068882 no 1782 0.487348498489769 578 17174189 SGTC_3298 9116858 71.43 µM -0.0319862130440317 0.477112478090488 no 1783 0.487241522834797 574 2506942 SGTC_1225 1216-0074 20.6 µM -0.032358161599938 0.47697029450322 no 1784 0.487093213604138 558 4241466 SGTC_1306 1185-0270 9.02 µM -0.0327249347398502 0.476830092176448 no 1785 0.486946969745273 571 1548076 SGTC_703 3875-0075 71.8 µM -0.0327871139312966 0.476806323905926 no 1786 0.486922177141117 565 2850814 SGTC_2411 st077133 39.94 µM -0.0333583962157316 0.476587952602271 no 1787 0.486694393096885 558 1403142 YNL221C POP1 SGTC_713 1488-1073 324 µM -0.0334017975309698 0.476571362838582 no 1788 0.486677088120768 562 3312542 SGTC_2684 capsaicin 100 µM -0.0334248669969703 0.47656254475853 no 1789 0.486667889871524 563 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_15 0266-0086 27.098 µM -0.0337205125503389 0.476449538125326 no 1790 0.486550010811672 564 1712902 YIL048W NEO1 SGTC_1202 1988-0068 29.6 µM -0.0354364210981469 0.475793692283928 no 1791 0.485865871551332 562 2850480 SGTC_729 4092-0585 94.1 µM -0.0354924652795644 0.475772272458061 no 1792 0.485843527213752 566 2169061 SGTC_793 0488-0545 106 µM -0.0355280230990246 0.475758682460894 no 1793 0.485829350637161 567 292548 SGTC_60 0986-0278 202 µM -0.0355530980204236 0.475749098984935 no 1794 0.485819353506677 562 3110598 SGTC_3212 9128307 49.47 µM -0.0357558783033615 0.47567159816257 no 1795 0.485738507282234 588 27243542 SGTC_1937 st074714 47.2 µM -0.0361418038327095 0.475524103399493 no 1796 0.485584644724339 584 17250970 SGTC_3165 9101544 49.47 µM -0.0369979705715131 0.475196901728558 no 1797 0.485243311941736 569 5002184 SGTC_156 3474-0145 5.642 µM -0.0384191918659885 0.474653789911226 no 1798 0.484676729690605 561 2265471 SGTC_67 0335-0847 266 µM -0.0403400522061107 0.473919818842532 no 1799 0.483911011354678 595 4552207 YOR254C SEC63 SGTC_2285 7945142 200 µM -0.0410646990894705 0.473642950232241 no 1800 0.48362215844889 565 2970608 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0427467136308675 0.473000345791976 no 1801 0.482951720743436 573 165506 SGTC_1980 st071811 45.7 µM -0.0441653124742703 0.472458432424817 no 1802 0.482386315847749 566 4974850 SGTC_554 4483-2211 187 µM -0.0443824437748603 0.472375491423752 no 1803 0.482299777848158 577 747107 SGTC_5 0352-0601 109.883 µM -0.0451396439463166 0.472086261358728 no 1804 0.481998001156218 562 762456 SGTC_58 0957-0393 9 µM -0.0456910776549145 0.471875637792897 no 1805 0.48177823769182 562 6997992 SGTC_2541 muurolladie-3-one 83.07 µM -0.045734396046107 0.471859092393939 no 1806 0.481760974200846 580 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_819 1013-0258 27.7 µM -0.0460293832465859 0.47174642373794 no 1807 0.481643415139569 585 5753198 SGTC_1958 st076513 41.9 µM -0.0464003075110949 0.471604754569404 no 1808 0.481495595710045 580 732122 YGL099W LSG1 SGTC_1855 st056195 39.6 µM -0.047910809464372 0.471027877447222 no 1809 0.480893662289224 560 4028379 SGTC_3010 9080089 71.4286 µM -0.0482550140027101 0.470896430451621 no 1810 0.480756503191741 575 17027233 SGTC_1845 st056753 3.01 µM -0.0492760994102085 0.470506510638822 no 1811 0.480349633140845 580 5375839 SGTC_1209 2323-2347 50.3 µM -0.0499715174382519 0.470240968931049 no 1812 0.480072542873093 562 5412760 SGTC_976 1348-1067 47.6 µM -0.0502716479266606 0.470126369767414 no 1813 0.479952958434856 565 5310671 YGL099W LSG1 SGTC_3333 9141820 12.094 µM -0.0518084108844389 0.469539624803012 no 1814 0.479340676818549 575 1939433 SGTC_3185 9108267 49.47 µM -0.0525517017040701 0.469255855731931 no 1815 0.479044550106038 585 4910486 SGTC_2798 7813637 45.45 µM -0.0534615840353028 0.468908507634522 no 1816 0.478682069176364 570 956368 SGTC_117 lucigenin 22.078 µM -0.0544324804993985 0.468537893460878 no 1817 0.478295300754435 602 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2594 a-mangostin 100 µM -0.0548332115261055 0.468384932868126 no 1818 0.478135670611594 573 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1587 estradiol valerate 56.1 µM -0.0566541832171912 0.467689920008867 no 1819 0.477410335926489 573 13791 A steroid. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0580058989367112 0.467174072310284 no 1820 0.476871964884283 575 6708760 SGTC_686 1319-0111 510 µM -0.0588571848400444 0.4668492290757 no 1821 0.476532930222967 574 4562600 SGTC_1646 st011709 75.6 µM -0.0594045609029299 0.466640366820351 no 1822 0.476314940200945 574 5757843 SGTC_374 0880-0231 82.3 µM -0.0606062579682758 0.46618186763522 no 1823 0.475836394775168 578 6833587 SGTC_1212 0520-0165 585 µM -0.061130569976915 0.465981834049694 no 1824 0.475627611674565 595 5403258 SGTC_161 4065-0411 162.148 µM -0.062167612030362 0.465586210944145 no 1825 0.475214677218915 583 1906281 YLR208W SEC13 SGTC_1505 k297-0037 20.6 µM -0.0626614413667378 0.465397830999845 no 1826 0.475018051178118 579 4089396 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.0627238508502034 0.465374024348341 no 1827 0.474993202277144 576 7104 SGTC_992 3909-8734 162 µM -0.0628613635530498 0.465321569344557 no 1828 0.474938450692726 589 4288319 SGTC_1089 terbinafine 2.25 µM -0.064057027917348 0.464865501857235 no 1829 0.474462409144803 582 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2028 5153890 36.43 µM -0.0653445838505773 0.464374435391378 no 1830 0.473949822696836 594 2830968 YPR165W RHO1 SGTC_2989 9073649 71.4286 µM -0.0661427652154576 0.46407004078356 no 1831 0.473632081828574 576 21367202 SGTC_2476 5806916 10.51 µM -0.0671973736741766 0.463667887365349 no 1832 0.473212287952554 582 2870194 SGTC_2054 5233173 129 µM -0.0672720213559589 0.46363942339692 no 1833 0.473182575070728 579 6889 SGTC_3066 9117245 49.47 µM -0.068148477145582 0.463305235285788 no 1834 0.472833720420863 594 17176980 SGTC_3211 9128781 49.47 µM -0.0684138652104625 0.463204049270114 no 1835 0.472728092424281 600 17194361 SGTC_1189 1431-2119 7.28 µM -0.0688290762079126 0.463045744191785 no 1836 0.472562836748439 573 3107275 SGTC_891 0929-0073 133 µM -0.0699674381431426 0.462611757658123 no 1837 0.472109788348391 616 5603632 SGTC_3198 9112019 49.47 µM -0.0709223903863395 0.462247728124063 no 1838 0.471729761646601 585 45595555 SGTC_496 calpeptin 138 µM -0.0720393990010278 0.461821962551764 no 1839 0.471285276709406 576 73364 A calpain inhibitor. SGTC_1257 0669-0121 16 µM -0.074987637944922 0.460698405845105 no 1840 0.470112273844778 581 4307855 SGTC_2275 7947463 200 µM -0.0771976714018666 0.459856380162478 no 1841 0.469233147036352 576 1225414 SGTC_515 4092-1064 102 µM -0.0778174461150206 0.459620277331118 no 1842 0.468986634269121 627 717353 SGTC_2790 5423970 71.43 µM -0.0779819811614473 0.459557600185437 no 1843 0.468921193144435 590 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_749 1000-0129 128 µM -0.0782467313825517 0.459456749690135 no 1844 0.468815894835744 592 708470 SGTC_1849 st056239 19.2 µM -0.0787543027341162 0.459263409381923 no 1845 0.468614026115612 582 5393181 SGTC_597 k018-0003 82.8 µM -0.0794856846049179 0.458984833788316 no 1846 0.468323158807772 585 6786234 SGTC_2841 9004761 38.96 µM -0.0814641802380058 0.458231347112081 no 1847 0.467536405098182 581 2991039 SGTC_2701 st077767 14.721 µM -0.0817167337898042 0.45813517582127 no 1848 0.467435985611852 608 5721188 SGTC_2311 7694451 200 µM -0.0832014052274441 0.457569869149745 no 1849 0.466845697702902 579 2163142 SGTC_2347 9049783 174.81 µM -0.0832383876609387 0.457555788730204 no 1850 0.46683099484749 596 6467988 YPL169C MEX67 SGTC_1439 4092-1168 46 µM -0.0836157010747013 0.457412136245569 no 1851 0.466680991501063 589 2886240 SGTC_2323 6148992 148.28 µM -0.0845867180187143 0.457042471873038 no 1852 0.466294979353529 587 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1112 tnp00069 1.16933 µM -0.0847514565673226 0.456979759888234 no 1853 0.466229493332413 577 145826 SGTC_576 1073-0113 22.7 µM -0.0850820168103349 0.456853926824403 no 1854 0.466098093483362 597 5439563 SGTC_198 3454-2873 16.191 µM -0.0854072607557756 0.456730121716813 no 1855 0.465968810503999 597 710957 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0861657069093489 0.456441433194194 no 1856 0.46566734560499 602 23847180 SGTC_344 k064-0035 6.43 µM -0.0863904697629644 0.456355885773752 no 1857 0.465578011317478 598 5088750 SGTC_2163 5671233 125 µM -0.0864436568410993 0.456335642433864 no 1858 0.465556871824696 574 701023 SGTC_452 diindolylmethane 8 µM -0.0866407265467375 0.456260637440031 no 1859 0.465478546248632 604 3071 Inhibits expression of several cancer promoting factors. SGTC_3346 9158254 43.5805 µM -0.087006818096729 0.456121306644788 no 1860 0.46533304630252 574 17639500 SGTC_711 k292-0785 179 µM -0.0871941807132936 0.456050000386508 no 1861 0.465258582429488 593 4146315 SGTC_135 0933-0004 26.348 µM -0.0874987925406028 0.455934074575122 no 1862 0.465137522582407 581 21230617 YGL099W LSG1 SGTC_1092 toremifene 6.32 µM -0.0877610776815667 0.455834259992668 no 1863 0.465033286932812 624 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.087824797099249 0.455810011509784 no 1864 0.465007964339513 590 3256 An antibiotic and ribosome inhibitor. SGTC_31 0508-1974 57.237 µM -0.0878488236836849 0.455800868213754 no 1865 0.464998416024349 563 6810525 SGTC_2471 5466956 24.79 µM -0.0893145002714199 0.455243150699245 no 1866 0.464415985287287 581 724419 SGTC_2073 5212005 126 µM -0.0896515972764343 0.455114891382888 no 1867 0.464282040377861 586 691789 SGTC_191 3914-0123 66.505 µM -0.0899537513002741 0.454999931215123 no 1868 0.464161983441138 610 3144412 SGTC_894 0960-0238 55.9 µM -0.0905079970486737 0.45478906782394 no 1869 0.463941769655737 577 6741907 YDL195W SEC31 SGTC_2328 6201408 200 µM -0.0907510221405188 0.454696612680343 no 1870 0.46384521402689 609 2890418 SGTC_710 3448-4187 58 µM -0.0908572803041463 0.454656189173564 no 1871 0.463802997557772 582 3946412 SGTC_813 k007-0158 173 µM -0.0912757680141833 0.454496989592589 no 1872 0.463636735961943 582 6523916 SGTC_118 0083-0097 135.343 µM -0.0919040807479257 0.454257982867933 no 1873 0.463387124609117 592 5207356 SGTC_1902 st060212 70.5 µM -0.0923317467230788 0.454095310539683 no 1874 0.463217232928143 586 688944 SGTC_1568 digitonin 820 nM -0.0940884755512502 0.4534271804714 no 1875 0.462519437473276 607 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_735 3076-0345 636 µM -0.0954256615939523 0.452918701775984 no 1876 0.461988367038101 582 2888990 SGTC_3075 9116269 49.47 µM -0.0956646585271464 0.452827828850221 no 1877 0.461893455265971 594 17015205 YNL244C SUI1 SGTC_877 0771-0151 33.1 µM -0.0962991339607454 0.452586596584976 no 1878 0.461641499445476 616 6166523 SGTC_906 1165-0455 526 µM -0.0965198584670253 0.452502679589121 no 1879 0.461553851390942 619 3252859 SGTC_11 0438-0307 1.3 µM -0.0966178791738275 0.452465413889547 no 1880 0.461514928698125 598 4011476 SGTC_2853 9015042 58.44 µM -0.0966553426319874 0.452451171071037 no 1881 0.461500052564505 574 6457456 SGTC_668 1682-0499 62.6 µM -0.097550508368548 0.452110866132044 no 1882 0.46114461278926 585 682214 SGTC_769 0302-0231 76 µM -0.0977786656141518 0.452024135812783 no 1883 0.461054024282884 587 571869 YER009W NTF2 SGTC_201 4262-0159 12.803 µM -0.0991718629882702 0.451494583991399 no 1884 0.460500907393955 579 1341029 SGTC_1231 0242-0792 125 µM -0.0997613838295156 0.451270534108642 no 1885 0.460266883148902 607 3707635 SGTC_2757 clomiphene 4.22 µM -0.101395191290323 0.450649680032139 no 1886 0.459618376798492 592 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_697 0508-1955 564 µM -0.101878204829668 0.450466155800939 no 1887 0.4594266749806 584 6243113 SGTC_953 1188-0045 9.7 µM -0.103875462299392 0.449707397309522 no 1888 0.458634089997449 599 6144426 SGTC_137 0438-0332 85.389 µM -0.104262258499193 0.449560474522303 no 1889 0.458480613992449 616 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2229 7354935 190 µM -0.105967415571967 0.448912861019013 no 1890 0.457804102596601 595 318112 SGTC_2768 sulfasalazine 50.2 µM -0.106472505200035 0.448721055552754 no 1891 0.457603734529414 623 5384001 An antioxidant and salicylic acid derivative. SGTC_795 0685-0265 78 µM -0.107342900816615 0.448390554961208 no 1892 0.457258475602925 595 302754 SGTC_1270 0831-1170 17.3 µM -0.107429702607774 0.448357597146902 no 1893 0.45722404579101 591 6764716 SGTC_3301 9125354 19.7965 µM -0.107764462848363 0.448230495208311 no 1894 0.457091266607785 594 41905162 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.108042842074388 0.448124804088549 no 1895 0.456980854017364 595 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_381 3461-2219 42.7 µM -0.108490076632638 0.447955012058002 no 1896 0.456803475876776 624 2883159 SGTC_1640 st009078 66.4 µM -0.109900074002883 0.44741977091384 no 1897 0.45624431192719 601 690618 SGTC_3166 9102297 49.47 µM -0.110089967076042 0.447347693969798 no 1898 0.456169012452848 609 25237072 SGTC_2083 5306046 65.942 µM -0.110105959767605 0.447341623768043 no 1899 0.456162670843817 599 539837 SGTC_738 1315-0003 72.4 µM -0.110615656730912 0.447148169155305 no 1900 0.45596056570289 626 6251474 SGTC_864 0469-0573 172 µM -0.110725350238423 0.447106536814404 no 1901 0.455917071499769 625 689425 SGTC_2626 ethyl orsellinate 100 µM -0.111361687657167 0.446865037074243 no 1902 0.45566476993091 596 75653 A natural product. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.114800127571276 0.445560439880406 no 1903 0.454301773969332 600 6708739 YPR165W RHO1 SGTC_3340 9146634 11.102 µM -0.114962492565529 0.445498850553647 no 1904 0.45423742573727 591 4907387 SGTC_3162 9099653 49.47 µM -0.116690585083492 0.444843421250534 no 1905 0.453552625659149 592 25237511 SGTC_1375 2910-0797 186 µM -0.119296321904644 0.443855405467837 no 1906 0.452520298693241 591 742508 SGTC_2064 5220758 200 µM -0.119432419496553 0.443803810952878 no 1907 0.452466389029312 598 788518 SGTC_126 0417-1624 672.48 µM -0.119549646490604 0.443759371033704 no 1908 0.452419954906795 614 41912 YDL195W SEC31 SGTC_3281 9140613 49.47 µM -0.120013834829196 0.443583407488115 no 1909 0.452236094281887 609 16013766 SGTC_754 3474-0146 171 µM -0.120339697019706 0.443459886972821 no 1910 0.452107029456774 599 24762078 SGTC_1486 3970-0793 4.53 µM -0.121375183506964 0.443067414549225 no 1911 0.45169693611625 620 2844330 SGTC_1062 mesoridazine 14.2 µM -0.121431646210331 0.44304601553037 no 1912 0.451674576144723 593 4078 A neuroleptic. SGTC_2313 7726885 200 µM -0.122904590580877 0.442487837507259 no 1913 0.451091325216232 601 726423 SGTC_912 3474-0017 2.18 µM -0.123791213199169 0.442151903365536 no 1914 0.450740294575445 612 3360550 SGTC_1791 st048313 56.1 µM -0.124315239357745 0.441953373633177 no 1915 0.450532840818222 587 1204976 SGTC_1860 st056228 74.6 µM -0.124470054376788 0.441894724035334 no 1916 0.45047155455792 597 688679 SGTC_446 go6976 132 µM -0.124832192342989 0.441757537890802 no 1917 0.450328200461043 596 3501 A protein kinase C inhibitor. SGTC_458 nppb 133 µM -0.125778438798648 0.441399111107282 no 1918 0.449953654778569 605 4549 A chloride channel blocker. SGTC_57 miconazole 162.5 nM -0.12619446896288 0.441241539051545 no 1919 0.449788994746896 623 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1271 0832-2808 169 µM -0.126647979441596 0.441069781865784 no 1920 0.449609510279602 633 3663794 SGTC_1064 honokiol 6.76 µM -0.126900276400659 0.440974234700712 no 1921 0.449509663937311 620 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_761 k216-0224 480 µM -0.126934327018762 0.440961339683341 no 1922 0.449496188674082 618 1340404 SGTC_942 3253-1115 227 µM -0.127680277716315 0.440678862825849 no 1923 0.449200999216787 604 46497897 SGTC_2105 5350118 200 µM -0.129334727245374 0.440052463241299 no 1924 0.448546396909248 608 2133313 SGTC_3093 9117344 49.47 µM -0.129462820398222 0.440003971475768 no 1925 0.448495721174034 599 24824913 SGTC_1817 st052116 64.4 µM -0.129520509329172 0.439982132677937 no 1926 0.448472898768822 604 4361398 SGTC_552 k242-0005 476 µM -0.129544245338817 0.439973147195821 no 1927 0.448463508579663 611 4088318 SGTC_444 curcumin 90.4 µM -0.130984976248491 0.439427803482286 no 1928 0.447893596109841 612 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2593 nobiletin 86.24 µM -0.131002689106731 0.439421099545787 no 1929 0.447886590070046 601 72344 An anti-infammatory. SGTC_990 3985-0011 41.3 µM -0.131341106178524 0.439293019289946 no 1930 0.447752737696357 635 5399565 YGL099W LSG1 SGTC_2540 epiandrosterone 100 µM -0.131453664509228 0.439250420897001 no 1931 0.447708219393167 599 441302 A steroid. SGTC_291 SEC14.278 35.5 µM -0.132318988866548 0.438922957098283 no 1932 0.447365994244203 605 1068044 SGTC_2011 4012611 177 µM -0.133762359428564 0.438376836991838 no 1933 0.44679524623545 621 2049887 SGTC_1709 st033179 39.1045 µM -0.136428485481633 0.437368378935141 no 1934 0.445741278021839 613 573381 SGTC_2395 5646831 180.19 µM -0.139108077727737 0.436355237139741 no 1935 0.444682372593791 630 6808628 SGTC_1844 rapamycin 4 nM -0.139420803515621 0.436237023996425 no 1936 0.444558817037911 626 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2381 9035592 200 µM -0.14080583665267 0.435713537701265 no 1937 0.444011666012911 639 4749657 SGTC_3303 9125618 40.5795 µM -0.14193721946916 0.435286004456395 no 1938 0.443564797518663 626 22695467 SGTC_592 k241-0073 46.5 µM -0.142095833056839 0.435226072703653 no 1939 0.443502154759599 604 4230158 SGTC_596 1155-0152 116 µM -0.142995653713375 0.434886105892328 no 1940 0.443146806876432 599 280313 SGTC_1185 1319-0113 81.3 µM -0.143079964151691 0.434854254506248 no 1941 0.443113514206857 624 4672763 SGTC_2933 9026794 32.47 µM -0.143592530415556 0.434660622749501 no 1942 0.442911119696525 628 17586027 SGTC_470 aa-861 153 µM -0.144697017753018 0.434243434758587 no 1943 0.44247504693338 608 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2279 7948423 32.93 µM -0.145276180890727 0.434024701951795 no 1944 0.442246410048001 597 1247112 SGTC_2190 6049624 200 µM -0.147174344875723 0.433307963428635 no 1945 0.441497204946056 614 2265554 SGTC_989 1501-0895 10.3 µM -0.147563189158371 0.433161164492733 no 1946 0.441343753892677 611 2830112 SGTC_1060 3448-7350 82 µM -0.148036062622097 0.432982654761238 no 1947 0.441157153960093 636 570178 SGTC_2612 dictamnine 15.46 µM -0.148290762163245 0.432886511348884 no 1948 0.441056652742154 625 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_460 trequinsin 123 µM -0.148490007959782 0.432811303260965 no 1949 0.440978035516368 600 5537 A vasodilator. SGTC_1085 doxorubicin 7.67 µM -0.149006747802776 0.432616263991468 no 1950 0.440774154216976 609 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1656 st012921 11 µM -0.149019630456359 0.432611401747733 no 1951 0.440769071526592 604 6732821 SGTC_378 3970-0959 8.33 µM -0.149701940754723 0.432353894948768 no 1952 0.440499888468099 641 6615653 SGTC_1210 3013-0140 750 nM -0.150520308317729 0.432045077466902 no 1953 0.440177064771296 622 905973 SGTC_2090 5301565 104.445 µM -0.150706931719695 0.431974659454687 no 1954 0.440103452486329 631 2056344 SGTC_2402 5553605 200 µM -0.151293526423339 0.431753335631623 no 1955 0.439872087834368 638 6758546 SGTC_1269 0831-0796 3.05 µM -0.152751314932893 0.431203400857608 no 1956 0.439297196051733 609 927758 SGTC_557 1315-0110 16.2 µM -0.153063308687813 0.431085721911935 no 1957 0.439174175145395 607 6833801 SGTC_940 3232-1287 54.8 µM -0.153311028899392 0.43099229025298 no 1958 0.439076501845004 629 1585493 YIL048W NEO1 SGTC_86 0417-1630 471.922 µM -0.153491356420187 0.430924279258961 no 1959 0.439005403059156 611 3634867 SGTC_1548 st061468 90.8 µM -0.15365427324849 0.43086283651418 no 1960 0.438941170580826 606 390799 SGTC_2520 obtusaquinone 4.71 µM -0.154046746981694 0.430714825140869 no 1961 0.438786438349371 606 5967872 SGTC_593 1203-0218 61.7 µM -0.154735703668057 0.430455026396587 no 1962 0.438514840758148 629 3666956 SGTC_1230 0170-0365 3.77 µM -0.155233849591538 0.430267199244502 no 1963 0.438318481806676 628 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3088 9117578 49.47 µM -0.156069886454264 0.429952004958588 no 1964 0.437988967295602 604 678341 SGTC_2398 5228213 48.84 µM -0.156537719987935 0.429775646486992 no 1965 0.437804594724411 625 80771 YMR134W ERG29 SGTC_2658 polymyxin b sulfate 77.05 µM -0.158140349293684 0.429171612260625 no 1966 0.437173103243112 615 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1012 4112-3522 18 µM -0.158188124071907 0.429153608388316 no 1967 0.437154280773433 633 3112398 SGTC_2666 tannic acid 100 µM -0.158261722618136 0.429125873146033 no 1968 0.437125284446149 618 16134267 A thiamine antagonist. SGTC_1874 staurosporine 7.6 µM -0.158634964771692 0.428985224105773 no 1969 0.436978239846965 609 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.160983833887743 0.428100306124771 no 1970 0.436053066626983 612 16623 A steroid. SGTC_1835 st008666 49.2 µM -0.161419672146237 0.427936147111374 no 1971 0.435881436855712 623 690455 SGTC_2703 st077852 53.4 µM -0.162364311967731 0.427580390214731 no 1972 0.435509486409754 644 6281836 SGTC_2661 dactinomycin 12.96 µM -0.162612028830841 0.427487108323267 no 1973 0.435411957711624 612 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_665 3914-0008 307 µM -0.164270094971712 0.426862840648535 no 1974 0.434759261310493 645 1069549 SGTC_1701 st028638 40.4 µM -0.164478172861673 0.426784511500277 no 1975 0.434677364133799 627 3490878 SGTC_2936 9038235 15.59 µM -0.164832129104977 0.42665127432369 no 1976 0.434538057277206 606 4749415 SGTC_3187 9109394 49.47 µM -0.167837575122342 0.425520294846482 no 1977 0.433355530552403 622 17098090 SGTC_1139 k015-0024 46.9 µM -0.168518264205543 0.425264229461522 no 1978 0.433087788189837 656 2766652 SGTC_1715 st032160 10.2275 µM -0.17135130461615 0.424198820470375 no 1979 0.431973770844676 634 5289825 SGTC_2260 7964312 200 µM -0.171566242337755 0.424118012291308 no 1980 0.431889274292689 646 231951 SGTC_230 MPP+ 141.667 µM -0.171775398560795 0.424039380792183 no 1981 0.431807053560955 646 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2696 st077691 74.316 µM -0.174187917785275 0.423132622590878 no 1982 0.430858890297381 651 757133 SGTC_2460 5552655 174.22 µM -0.174411399365732 0.423048646373795 no 1983 0.43077107811207 618 5401989 SGTC_2408 sulbentine 18.36 µM -0.174842659871797 0.422886604310155 no 1984 0.430601633434168 614 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3201 9113999 49.47 µM -0.175220622438806 0.422744599170208 no 1985 0.43045314032044 655 16649224 SGTC_221 trifluoperazine 10.304 µM -0.175622645915693 0.422593565071339 no 1986 0.430295205001956 623 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2153 5569715 200 µM -0.175777310067156 0.422535463134363 no 1987 0.430234448006567 632 2054701 SGTC_1254 0550-0035 264 µM -0.176924935096444 0.42210439309845 no 1988 0.429783676105756 650 15121435 SGTC_884 0851-0618 334 µM -0.177854796733599 0.421755187579892 no 1989 0.429418505868803 664 9642473 SGTC_370 0180-0345 38.7 µM -0.177879188824882 0.4217460280623 no 1990 0.42940892755001 628 3989527 SGTC_3018 9082602 49.47 µM -0.178146090129736 0.421645806245587 no 1991 0.429304123107711 629 17332089 SGTC_1626 st003712 1.76 µM -0.178999502357551 0.421325382838469 no 1992 0.428969046222146 658 24207035 SGTC_3019 9081971 49.47 µM -0.183663413772651 0.419575189531052 no 1993 0.427138756089064 644 16451803 SGTC_2908 7930301 100 µM -0.18403065644634 0.419437444020305 no 1994 0.426994702631906 642 2223178 SGTC_928 2764-0428 58.7 µM -0.184476648935932 0.41927017427673 no 1995 0.426819772111835 633 662578 SGTC_1414 3917-0015 5.4 µM -0.185794208988301 0.418776107932966 no 1996 0.426303073011903 630 6618702 SGTC_1933 st074711 15.9 µM -0.186726677663988 0.41842652275136 no 1997 0.425937469109078 621 17250958 SGTC_1619 st003326 88.7 µM -0.187196635995356 0.418250358423328 no 1998 0.425753231153035 607 2849032 SGTC_2689 tacrolimus 100 µM -0.189233528646968 0.417487017267223 no 1999 0.424954895156581 625 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_328 k915-0120 63.5 µM -0.190319166943437 0.417080292787783 no 2000 0.424529517544678 628 6624543 SGTC_2297 7971671 152.32 µM -0.192033641868043 0.416438161260048 no 2001 0.423857926704499 643 909016 SGTC_2170 morpholine 200 µM -0.193888075737192 0.415743861175956 no 2002 0.423131760355846 644 121171 Reacts with secondary amines. SGTC_2409 alverine citrate 63.97 µM -0.193956184935949 0.415718366082935 no 2003 0.423105094849007 627 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1385 3091-4834 14.1 µM -0.195065928029663 0.415303009644986 no 2004 0.422670667831236 630 4072814 SGTC_485 niflumic acid 177 µM -0.19524285454736 0.415236798036594 no 2005 0.422601415740244 643 4488 A COX2 inhibitor. SGTC_2424 5537928 59.2 µM -0.196259520907251 0.414856375412724 no 2006 0.422203521420869 646 5382802 SGTC_1312 1218-2183 165 µM -0.196276396633804 0.414850061419618 no 2007 0.422196917409803 624 6744073 SGTC_2071 5230951 39.92 µM -0.197703265750676 0.414316283126644 no 2008 0.421638617225378 616 1799272 SGTC_876 0720-0963 56.8 µM -0.200271861646477 0.413355794984894 no 2009 0.420633983941675 703 765861 SGTC_259 usnic acid 108.925 µM -0.202419195202686 0.4125532291036 no 2010 0.419794511695047 693 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_737 1950-0117 57.9 µM -0.203155161661399 0.412278245576229 no 2011 0.419506878893913 637 5393513 SGTC_2008 4012253 172 µM -0.204715287595389 0.411695468982219 no 2012 0.418897287793274 635 603940 SGTC_3060 1327-0027 12.5 µM -0.206789848358411 0.410920829885894 no 2013 0.418086992318165 626 16000455 YPR107C YTH1 SGTC_2421 5690543 90.72 µM -0.206829105470466 0.410906174654465 no 2014 0.41807166235924 666 3397993 SGTC_2563 tomatine 8.54 µM -0.207246262784061 0.410750451654833 no 2015 0.417908769519448 684 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_586 0957-0265 8.15 µM -0.207380604448366 0.410700305492658 no 2016 0.417856314379628 643 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_762 1165-0429 115 µM -0.208020010012753 0.410461652459453 no 2017 0.417606671683322 620 5967793 SGTC_75 0159-0059 199.013 µM -0.209185523495066 0.410026719183022 no 2018 0.417151706506414 615 5377270 SGTC_2920 7982904 15.77 µM -0.210802148999153 0.409423628279559 no 2019 0.416520830783455 664 6456808 SGTC_235 0330-0087 5 mM -0.210997030726115 0.40935094104063 no 2020 0.416444794169038 638 46494818 YHR062C RPP1 SGTC_476 mead acid 10 µM -0.211049720117842 0.409331289418129 no 2021 0.416424236991045 638 5312531 An omega 9 fatty acid. SGTC_1005 4092-0690 4.4 µM -0.213753929657935 0.408323004302861 no 2022 0.415369476671289 660 1529343 SGTC_80 0159-0065 512.242 µM -0.215800371306142 0.407560375824667 no 2023 0.414571679438655 641 1548079 SGTC_2126 5251174 33.877 µM -0.216814018439111 0.407182758831056 no 2024 0.414176643338628 651 790722 SGTC_3237 9133362 49.47 µM -0.216971390631071 0.407124140224662 no 2025 0.414115320405108 689 43845137 SGTC_2497 7-hydroxyflavone 100 µM -0.217784466413599 0.406821315759238 no 2026 0.41379852404279 658 5281894 SGTC_2663 amphotericin b 100 µM -0.217932237130985 0.406766285551657 no 2027 0.413740954583821 659 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2272 7805186 180 µM -0.219734510124413 0.406095262763253 no 2028 0.413038963125294 699 2956062 YPR165W RHO1 SGTC_641 4092-0595 30 µM -0.219979904155651 0.406003918874033 no 2029 0.41294340276641 637 786260 SGTC_632 0781-2353 4.65 µM -0.22062150780715 0.405765116664848 no 2030 0.412693576436094 653 6811515 YHR007C ERG11 SGTC_2654 protoveratrine a 100 µM -0.220654737046232 0.405752749834605 no 2031 0.412680638664549 659 5702278 A heart drug and vasodilator. SGTC_938 3126-1755 342 µM -0.221133152052346 0.40557470993095 no 2032 0.41249437877394 634 1777771 SGTC_1667 st014849 34.6 µM -0.22117638893483 0.405558620489546 no 2033 0.412477546457392 635 5348460 SGTC_425 3825-7017 13.1 µM -0.223260416738111 0.404783295357066 no 2034 0.41166641630135 667 3397440 SGTC_1687 st020778 55.3625 µM -0.224379356662872 0.404367167818872 no 2035 0.411231066100455 641 4259299 SGTC_1827 berberine 7.24 µM -0.224438240673321 0.404345272174525 no 2036 0.411208158897594 666 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1717 st033143 58.0435 µM -0.224546096574676 0.404305167421396 no 2037 0.411166201314192 665 674616 SGTC_724 3910-0327 137 µM -0.224818895534958 0.404203735319523 no 2038 0.41106008291264 670 2885483 SGTC_637 1181-0519 7.26 µM -0.224871632922866 0.404184127247988 no 2039 0.41103956889536 664 6252091 YGR060W ERG25 SGTC_882 0843-0131 351 µM -0.224996436236112 0.404137725599762 no 2040 0.410991023331874 649 5425421 SGTC_51 1013-0126 23.419 µM -0.225670420419505 0.403887162812328 no 2041 0.410728882859094 661 1627850 SGTC_419 nsc-638432 893 µM -0.225859189598163 0.403816992366999 no 2042 0.410655469818578 658 368090 SGTC_1382 3002-2117 298 µM -0.226169103073409 0.403701796128848 no 2043 0.410534950096018 660 1497314 SGTC_2941 9056145 11.23 µM -0.22845980576194 0.402850591268645 no 2044 0.409644400113969 663 2119517 SGTC_1351 1496-0003 46.5 µM -0.228826790869652 0.402714265517614 no 2045 0.409501771542145 636 3891978 SGTC_54 0159-0055 9 µM -0.229363426214132 0.402514940261582 no 2046 0.40929323006047 716 3319099 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.229449946566826 0.402482805927975 no 2047 0.40925960984859 641 688761 SGTC_2514 salinomycin 42.74 µM -0.231387412208771 0.401763389054492 no 2048 0.408506921725631 679 23682228 A polyether potassium ionophore. SGTC_2705 st078069 42.8 µM -0.232898902193743 0.401202375764844 no 2049 0.407919955463954 675 1530061 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.233686242229959 0.400910222711772 no 2050 0.407614284588806 628 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1027 k015-0025 8.67 µM -0.234438289817493 0.400631217129321 no 2051 0.407322367892316 636 3598955 SGTC_3011 9081274 71.4286 µM -0.234585663109429 0.40057654837148 no 2052 0.407265169127658 635 6625322 SGTC_2846 9008642 19.48 µM -0.234987827018356 0.400427373847639 no 2053 0.407109090673552 716 2992898 SGTC_866 0495-0101 262 µM -0.235200422635488 0.400348521693395 no 2054 0.407026588990696 647 635694 SGTC_2533 agelasine 13.65 µM -0.241107987696666 0.398159029104232 no 2055 0.404735711046704 657 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_260 nsc-65238 3.989 µM -0.241113850948007 0.398156857615139 no 2056 0.404733438960334 649 3246252 SGTC_1968 st069590 43.6 µM -0.241140042362454 0.398147157511619 no 2057 0.404723289484839 657 6384066 SGTC_1426 4048-4480 71.7 µM -0.242368086249415 0.397692416917257 no 2058 0.404247480376706 667 14224343 SGTC_1491 4138-0063 26.5 µM -0.243044313033388 0.397442071668238 no 2059 0.403985534789905 671 23883227 SGTC_2874 9043904 71.43 µM -0.245295860258587 0.396608833588536 no 2060 0.403113678446034 658 4463428 SGTC_1133 3473-0247 50 µM -0.247015655939615 0.395972700369959 no 2061 0.402448053881249 663 711311 SGTC_575 k072-0246 11.9 µM -0.247175953284524 0.395913422255633 no 2062 0.402386027252197 649 6796779 SGTC_1419 3993-2473 62.6 µM -0.247954232096982 0.39562564823116 no 2063 0.40208490930586 650 704026 SGTC_2375 9072683 200 µM -0.248621019202239 0.395379144288895 no 2064 0.401826973977216 665 16798029 SGTC_323 4013-0906 34.3 µM -0.249306284036086 0.395125852941387 no 2065 0.401561935402376 656 2910086 SGTC_814 3342-0569 96 µM -0.254519134753057 0.393200508280173 no 2066 0.399547261658618 654 4346283 SGTC_786 4544-0069 423 µM -0.254836527841416 0.393083364267102 no 2067 0.399424680651254 647 748821 YLR208W SEC13 SGTC_2022 5136654 200 µM -0.255738086094424 0.392750668360062 no 2068 0.3990765421861 689 1713771 SGTC_1504 k297-0033 30 µM -0.256525772783149 0.392460057816659 no 2069 0.398772441129969 648 4388117 SGTC_3003 9075612 71.4286 µM -0.259296986345009 0.391438118833917 no 2070 0.397703052232484 698 6501993 SGTC_1941 st076221 61.8 µM -0.259553415584449 0.391343593303319 no 2071 0.397604136974491 634 2828568 SGTC_2041 5107442 45.335 µM -0.259573058518975 0.39133635274455 no 2072 0.397596560161683 654 793005 SGTC_2223 6903751 107.57 µM -0.259784961865258 0.391258245698301 no 2073 0.397514825748446 674 5598863 SGTC_1757 st041620 31.8375 µM -0.262849664229901 0.390129095840452 no 2074 0.396333227239891 671 5289815 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.267812030380447 0.388302744355081 no 2075 0.394422004993093 651 688664 SGTC_1234 0326-0494 15.5 µM -0.269065268135141 0.387841890780244 no 2076 0.393939728572144 701 1547813 SGTC_409 arachidonic acid 100 µM -0.272600144407174 0.38654286240014 no 2077 0.392580300460931 663 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_445 e6 berbamine 66 µM -0.274207260313066 0.385952684066661 no 2078 0.391962674481011 678 6610268 A calcium/calmodulin antagonist. SGTC_1597 7-benzyloxygramine 47.5 µM -0.274870243670404 0.385709294656742 no 2079 0.391707964498481 677 260807 SGTC_2998 9066762 71.4286 µM -0.276177011800838 0.385229695692631 no 2080 0.391206056386904 689 4945196 SGTC_3339 9145883 14.936 µM -0.276206830159432 0.38521875405649 no 2081 0.391194605756997 694 2030670 SGTC_2837 9008476 45.46 µM -0.276460474827927 0.385125684631672 no 2082 0.391097206784117 718 2992805 SGTC_34 0469-0683 81.75 µM -0.2777363239567 0.384657639841481 no 2083 0.390607387330117 662 3690923 SGTC_2118 5526350 200 µM -0.278132336303418 0.384512397002744 no 2084 0.390455386937449 685 743594 SGTC_1410 3909-8106 77.9 µM -0.278596504310839 0.384342177797849 no 2085 0.390277247846511 674 1039210 SGTC_2432 5630864 12.22 µM -0.280070661078978 0.383801724602764 no 2086 0.389711646677865 696 5714970 SGTC_834 0312-0008 75.7 µM -0.280346656842371 0.383700564519109 no 2087 0.389605779154473 675 6385573 YIL048W NEO1 SGTC_182 3448-4371 550.524 µM -0.280634909466955 0.383594920418213 no 2088 0.389495218841786 635 3491403 SGTC_2864 9034755 47.6 µM -0.280664460101699 0.383584090649263 no 2089 0.389483885096682 658 4930451 SGTC_1058 3448-5425 97.3 µM -0.281042716156249 0.383445474735778 no 2090 0.389338818423527 666 7279705 SGTC_3084 9116877 49.47 µM -0.281422321731671 0.38330637927357 no 2091 0.389193249692879 677 27241325 SGTC_1124 fisetin 1.16336 µM -0.282234132564556 0.383008965218964 no 2092 0.388881993851433 694 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_309 k408-0051 1.48 µM -0.283593123102202 0.382511241470282 no 2093 0.38836110390354 674 3640463 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.283627640016723 0.382498602339403 no 2094 0.388347876462712 720 688798 SGTC_499 genistein 192 µM -0.285293316894087 0.381888826943444 no 2095 0.387709716273947 675 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3244 9134489 49.47 µM -0.286475675745943 0.381456163549112 no 2096 0.387256910540168 708 16584271 SGTC_2823 7987624 58.44 µM -0.286510841903096 0.381443297378584 no 2097 0.387243445368859 729 2239440 SGTC_3182 9108849 49.47 µM -0.288681108629757 0.380649520354788 no 2098 0.386412710312639 669 17133045 SGTC_3219 9131112 49.47 µM -0.289108748289067 0.380493169880134 no 2099 0.386249079582521 672 17612988 YMR079W SEC14 SGTC_986 1493-0483 84 µM -0.289498172160284 0.380350808561706 no 2100 0.386100089222117 700 40079 SGTC_1039 k821-0043 94 µM -0.289694363111799 0.380279093357298 no 2101 0.386025034543691 697 15992768 SGTC_231 b-estradiol 524 µM -0.290186448718286 0.380099235588902 no 2102 0.385836801378199 659 450 A steroid. SGTC_487 nimodipine 119 µM -0.290663288177717 0.379924975034889 no 2103 0.385654425827357 685 4497 L-type voltage-gated calcium channels inhibitor SGTC_1522 st012842 45.6 µM -0.29305365958553 0.379051784002202 no 2104 0.384740568375777 689 3491067 YOR116C RPO31 SGTC_2139 5578692 56.4705 µM -0.294294136689977 0.378598886572724 no 2105 0.384266576313533 688 650991 YMR113W FOL3 SGTC_2492 derrusnin 100 µM -0.295410170788162 0.378191565625212 no 2106 0.383840282326128 712 1715307 Part of coumarin class of compounds. SGTC_91 0417-1751 58.384 µM -0.29571980373799 0.378078582301555 no 2107 0.38372203603107 681 6795624 SGTC_2515 chrysin 20.77 µM -0.298119818231753 0.377203184796074 no 2108 0.382805858079335 676 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_715 0868-0130 184 µM -0.298524516394269 0.377055634471042 no 2109 0.382651433639472 673 2876258 SGTC_2576 guaiol 23.12 µM -0.30007681679167 0.376489842465813 no 2110 0.382059281160283 669 227829 SGTC_1932 st074806 40.9 µM -0.300349071004831 0.376390636880385 no 2111 0.381955453356383 669 17251235 SGTC_325 2810-4341 181 µM -0.301141071789646 0.376102089439203 no 2112 0.381653461507432 661 774970 SGTC_1877 wortmannin 25 µM -0.304347939167336 0.374934449757713 no 2113 0.380431413036003 697 312145 A covalent inhibitor of PI 3-kinase. SGTC_536 3852-0578 10.6 µM -0.304676708335643 0.374814807482521 no 2114 0.380306195379704 682 2869208 SGTC_2426 5582046 32.21 µM -0.305075633061536 0.374669651101383 no 2115 0.38015427455983 697 2251934 SGTC_62 0180-0423 3.232 µM -0.306315171475216 0.374218734763984 no 2116 0.379682344445605 703 30102 YGL099W LSG1 SGTC_579 4491-1009 110 µM -0.306785299429668 0.374047757694447 no 2117 0.379503399205795 688 1271041 SGTC_2469 5655019 90.81 µM -0.307352394907246 0.373841548252784 no 2118 0.379287579471336 691 2788239 SGTC_23 0213-0011 39.996 µM -0.307508346697844 0.373784846789147 no 2119 0.379228235432552 697 627608 SGTC_1563 conessine 56.1 µM -0.308993432771611 0.373245031338603 no 2120 0.378663261219319 689 441082 An anti-amoebic, histamine inhibitor. SGTC_509 pifithrin 175 µM -0.309032299889276 0.37323090682545 no 2121 0.378648478401031 690 4817 A p53 inhibitor. SGTC_1796 st049173 110.4 µM -0.310200280749173 0.372806536049146 no 2122 0.378204328523282 707 94134 SGTC_469 w7 172 µM -0.310836770935096 0.372575340480477 no 2123 0.377962357114619 671 45115570 A P450 inhibitor. SGTC_13 0199-0087 65 µM -0.311388974096329 0.372374798101369 no 2124 0.377752467474387 678 4589825 SGTC_615 k087-0205 167 µM -0.313511299791887 0.37160436034734 no 2125 0.376946118559287 672 9642773 SGTC_843 0310-0051 143 µM -0.314393908330333 0.371284110657255 no 2126 0.37661094111041 685 2065037 SGTC_630 4356-0227 183 µM -0.314431147251693 0.371270600675305 no 2127 0.376596801383665 706 779312 SGTC_1850 st056238 17 µM -0.315712983485303 0.370805657576634 no 2128 0.376110185492013 680 5393177 SGTC_2831 7999036 19.48 µM -0.315719446494668 0.370803313814016 no 2129 0.376107732476333 732 2988270 SGTC_774 k060-0086 136 µM -0.316227680992759 0.37061902134344 no 2130 0.375914849288342 736 5911235 SGTC_2377 9073351 62.6 µM -0.316604477104715 0.370482409308014 no 2131 0.375771869094224 719 7337946 YHR072W ERG7 SGTC_335 4077-0256 27.6 µM -0.316715934073956 0.370442002350793 no 2132 0.375729578562963 709 3121989 SGTC_920 mycophenolic acid 780.421 nM -0.317792656282104 0.370051727446427 no 2133 0.375321110801376 679 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2605 digitonin 300 nM -0.31913947233177 0.369563741129403 no 2134 0.374810376403411 692 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1398 3558-0053 112 µM -0.319493723800976 0.369435421507987 no 2135 0.374676074947645 669 4532369 SGTC_2182 6325192 200 µM -0.320232897588449 0.369167719287286 no 2136 0.374395893271363 650 736248 SGTC_1130 3454-2858 15.9 µM -0.320897687324325 0.368927010480386 no 2137 0.374143963289057 730 715628 YIL048W NEO1 SGTC_1989 st071868 50.2 µM -0.321395610218023 0.368746754917669 no 2138 0.373955304675249 703 16414057 SGTC_978 1416-0512 87.4 µM -0.322009694964729 0.368524486784062 no 2139 0.373722674933843 713 6814003 SGTC_2149 5554786 194.827 µM -0.322581698859957 0.368317489388375 no 2140 0.373506027782887 688 745063 YPR165W RHO1 SGTC_2243 6634756 200 µM -0.322736382648431 0.368261518811984 no 2141 0.373447447978838 666 885676 SGTC_1886 st057356 49.9 µM -0.323578023080024 0.367957029776058 no 2142 0.373128764291963 663 24207747 SGTC_2800 7887935 81.82 µM -0.324278365685165 0.3677037227473 no 2143 0.372863648584621 723 2961002 SGTC_1313 1220-0047 237 µM -0.324523150483144 0.367615200058486 no 2144 0.37277099913729 687 3528706 SGTC_2799 7812892 81.82 µM -0.324661129879897 0.367565305013262 no 2145 0.372718778079866 701 20205235 SGTC_1475 4092-1048 11.7 µM -0.325770872176696 0.367164089918636 no 2146 0.372298859094976 701 2881759 SGTC_1056 3448-1962 115 µM -0.326552211536416 0.366881692248468 no 2147 0.372003296588202 687 715507 SGTC_2151 5563267 85.4165 µM -0.330825799619094 0.365338377187053 no 2148 0.370388035946647 704 5310824 SGTC_2691 st077356 60.2 µM -0.331460976475515 0.365109181948171 no 2149 0.370148156388993 701 2839272 SGTC_766 1391-0721 126 µM -0.332130031486604 0.364867814323152 no 2150 0.369895537090215 714 1020919 YIL115C NUP159 SGTC_1427 4048-4900 550 nM -0.332464430715834 0.36474719684971 no 2151 0.369769296906292 719 24132586 SGTC_2611 pyromycin 23.93 µM -0.335448099226008 0.363671584378346 no 2152 0.368643544822902 682 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_33 0986-0033 35.816 µM -0.335823240138781 0.363536421888859 no 2153 0.368502081917088 684 2848082 SGTC_1797 st048695 56.8 µM -0.337244493372023 0.36302450150494 no 2154 0.367966299473196 732 592262 YIL048W NEO1 SGTC_773 4358-1457 44.6 µM -0.338360914913527 0.362622549778279 no 2155 0.36754561213872 734 1186886 SGTC_747 3448-8087 38.7 µM -0.339315618841995 0.362278942215825 no 2156 0.36718598886649 728 5168703 SGTC_3225 9130819 49.47 µM -0.342777822807947 0.36103379254208 no 2157 0.365882805567025 730 4547121 SGTC_2298 7976326 193.81 µM -0.342807512246381 0.361023121353303 no 2158 0.365871637043361 697 2235818 SGTC_2020 4017018 200 µM -0.343018338155279 0.360947347919825 no 2159 0.365792332172924 720 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1501 4491-0275 38.4 µM -0.345124145850574 0.36019079456719 no 2160 0.365000520822237 706 5104718 SGTC_764 1951-2361 146 µM -0.345734266429836 0.359971698706003 no 2161 0.364771214813673 709 5438930 SGTC_3251 9135047 49.47 µM -0.34841654216122 0.359009033095172 no 2162 0.363763690524715 696 17682963 SGTC_702 1488-0190 94 µM -0.349084501757858 0.358769442081274 no 2163 0.363512935698239 699 949357 SGTC_89 0302-0250 142.109 µM -0.34910405386455 0.358762429755497 no 2164 0.363505596635816 688 4203518 YLR208W SEC13 SGTC_1643 st009866 20.2 µM -0.349577919340386 0.358592493369818 no 2165 0.363327742212118 704 3156273 YOR207C RET1 SGTC_178 4092-0806 87.505 µM -0.349734187787289 0.358536458928471 no 2166 0.363269096930043 674 2169044 SGTC_3335 9143315 29.6265 µM -0.35057670008315 0.358234404976771 no 2167 0.362952969535384 680 4899691 SGTC_83 0170-0301 39.027 µM -0.350851639392325 0.358135854082641 no 2168 0.362849827024886 679 3089716 SGTC_1500 4488-1866 171 µM -0.352209835218293 0.3576491530109 no 2169 0.362340450758951 728 2900003 SGTC_2581 avocatin a 64 µM -0.352642288797816 0.35749423447292 no 2170 0.362178314937919 744 6710728 A skin care supplement. SGTC_3103 9120822 49.47 µM -0.352839252862558 0.357423683501371 no 2171 0.362104477215914 733 17141819 SGTC_486 niguldipine 82 µM -0.352981725175458 0.35737265408164 no 2172 0.362051070513855 682 1236 A calcium channel blocker. SGTC_2807 7945238 51.95 µM -0.353852102987106 0.357060965590974 no 2173 0.361724861910199 731 17148797 SGTC_2711 st079103 59.1 µM -0.355225569063387 0.356569311671297 no 2174 0.361210305437553 699 54693780 SGTC_547 1120-0019 610 nM -0.355936611657211 0.356314876260352 no 2175 0.360944018396834 707 3676939 SGTC_510 ag-490 170 µM -0.357234099981826 0.355850755351135 no 2176 0.360458279872081 711 5328779 SGTC_3000 9075062 71.4286 µM -0.357812605833283 0.355643888444177 no 2177 0.360241778119569 675 17057871 SGTC_1074 carmofur 3.8 µM -0.35856028927887 0.355376588595568 no 2178 0.35996202923269 707 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_176 1486-1328 72.834 µM -0.359150964791373 0.355165470000867 no 2179 0.359741078534392 681 22310231 SGTC_2730 imipramine 71.33 µM -0.359330980372802 0.355101137863627 no 2180 0.359673750423948 705 3696 A tricyclic antidepressant. SGTC_3145 9085516 49.47 µM -0.359355634484425 0.355092327549529 no 2181 0.359664529812553 687 25236195 SGTC_233 rapamycin 362 pM -0.360351025129068 0.354736682700295 no 2182 0.35929232305894 692 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3033 9090887 49.47 µM -0.36149270167345 0.354328926956093 no 2183 0.358865579939737 693 19325384 SGTC_2624 nerol 100 µM -0.364162058624781 0.35337620429131 no 2184 0.357868498715506 734 637566 A natural product oil. SGTC_1371 2421-0008 32.7 µM -0.364521481557581 0.353247992316287 no 2185 0.357734317830162 716 2827552 SGTC_918 glabranin 770.725 nM -0.365556835716042 0.352878757867684 no 2186 0.357347894505839 716 124049 Also referred to as licorice root. SGTC_2074 5212007 75.395 µM -0.365928888871305 0.352746107766838 no 2187 0.357209069487991 682 758611 SGTC_1332 1480-0653 17.5 µM -0.366442655767126 0.352562961137116 no 2188 0.357017397579604 725 5749438 SGTC_2852 9023854 51.95 µM -0.366568403754565 0.352518139941597 no 2189 0.356970490054201 748 19798528 SGTC_340 k038-0059 454 µM -0.367565854203038 0.352162684596615 no 2190 0.356598489715726 692 23733424 SGTC_676 falcarinol 140 µM -0.367643027535626 0.352135188183502 no 2191 0.356569713508185 748 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1066 ketoconazole 628 nM -0.367898874313172 0.35204403698306 no 2192 0.35647431981488 731 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1954 st077032 68.9 µM -0.370491689384497 0.351120768391482 no 2193 0.355508083814327 752 698907 SGTC_132 0417-1715 25.805 µM -0.374206889114247 0.349799364352735 no 2194 0.354125199480964 730 6769098 SGTC_2766 oltipraz 83.91 µM -0.374712279708988 0.349619749573092 no 2195 0.353937229353693 718 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2161 5662504 8.5105 µM -0.376855502491538 0.348858427039195 no 2196 0.353140495662155 671 2859334 SGTC_1317 1273-0028 910 nM -0.377167228329347 0.348747745362535 no 2197 0.353024666454883 715 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_106 0092-0003 11.579 µM -0.378644472985404 0.348223408616735 no 2198 0.352475946129818 718 1072148 SGTC_1762 st045503 25.4615 µM -0.380314521944557 0.347630986678772 no 2199 0.351855978513667 723 4645554 SGTC_356 1634-0012 32.5 µM -0.38231496298196 0.346921853276561 no 2200 0.351113878657006 753 735457 SGTC_2437 5741531 144.16 µM -0.384468600955613 0.346159012255089 no 2201 0.350315581867772 711 2262990 SGTC_2084 5306078 60.6385 µM -0.385907529959897 0.345649676010312 no 2202 0.3497825768495 726 679340 SGTC_1455 4262-0120 131 µM -0.390729677137397 0.343944826096914 no 2203 0.347998530032612 701 1529587 SGTC_687 k029-0044 34.9 µM -0.391596056637741 0.343638855969603 no 2204 0.347678351011364 730 5829338 SGTC_2026 5148700 152 µM -0.392640094307508 0.343270280246944 no 2205 0.347292660992944 698 79838 SGTC_2774 tamoxifen 10.92 µM -0.395530366726567 0.342250708088223 no 2206 0.34622575768401 713 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1169 aniline yellow 25.8 µM -0.396405739207031 0.341942138110539 no 2207 0.345902866434365 721 6051 A DNA damaging agent. SGTC_290 2043-6722 48.1 µM -0.397071719118683 0.341707449977498 no 2208 0.345657287075504 725 773758 YLR208W SEC13 SGTC_447 ml7 120 µM -0.399040156842862 0.341014139837023 no 2209 0.344931807775591 720 4216 Selective myosin light chain kinase inhibitor. SGTC_751 0833-0568 350 µM -0.399090643686553 0.340996364741218 no 2210 0.344913208034677 740 6954252 SGTC_3046 9092212 49.47 µM -0.399373092029635 0.340896928585847 no 2211 0.344809158810209 692 25236637 SGTC_820 1582-0060 59.9 µM -0.399963560053281 0.340689089575757 no 2212 0.344591678231767 726 3848840 SGTC_2096 5468907 200 µM -0.400668816648574 0.340440909478488 no 2213 0.344331986150693 706 759785 SGTC_2690 usnic acid 100 µM -0.400891996454461 0.3403623867939 no 2214 0.344249821370215 757 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3234 9132280 49.47 µM -0.402214459894362 0.339897238685877 no 2215 0.343763100680173 712 17612295 SGTC_2329 6138490 200 µM -0.402455730412919 0.339812403223 no 2216 0.343674331147732 749 720019 SGTC_1214 0358-0031 63.7 µM -0.402988118460064 0.339625233814055 no 2217 0.343478482605251 752 4301366 SGTC_601 0986-0029 62.9 µM -0.404055611099465 0.339250059122648 no 2218 0.343085912815668 729 24747981 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.404269238665014 0.339174997952702 no 2219 0.343007371721271 713 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1320 1313-0481 95.3 µM -0.404290363847771 0.339167575657469 no 2220 0.342999605325342 739 6813365 YLR208W SEC13 SGTC_1453 4237-0541 195 µM -0.40576176767454 0.33865075426383 no 2221 0.342458826406427 728 739892 SGTC_211 3455-0679 143.504 µM -0.40684469908053 0.33827057530987 no 2222 0.342061027278081 716 748649 SGTC_457 grayanotoxin iii 135 µM -0.407541021772881 0.338026208054245 no 2223 0.341805335780942 728 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_956 1185-0240 191 µM -0.409655068232418 0.337284723707169 no 2224 0.341029497363355 728 1416193 SGTC_2891 9063876 19.48 µM -0.410168374400617 0.337104780983547 no 2225 0.340841219261634 730 6472478 SGTC_861 0443-0273 110 µM -0.413017684930461 0.3361066156584 no 2226 0.339796828386923 724 6149169 SGTC_979 1426-2828 121 µM -0.415439170577608 0.335259232276857 no 2227 0.338910218384708 730 747872 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.415674691629585 0.335176857821725 no 2228 0.338824031502672 740 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_700 3453-2283 142 µM -0.416081959600018 0.335034432881164 no 2229 0.33867501524036 710 565664 SGTC_133 0724-0033 378.92 µM -0.416273975287713 0.33496729165062 no 2230 0.338604766913523 715 280309 SGTC_74 000s-0487 160.283 µM -0.418253638814367 0.334275379752666 no 2231 0.337880841068738 719 677548 SGTC_104 0074-0074 590.992 µM -0.41841437318526 0.33421922617514 no 2232 0.337822089789454 724 3943124 SGTC_828 2074-0507 139 µM -0.419485514673529 0.333845110862446 no 2233 0.337430669430276 716 X828 SGTC_908 3448-7491 47.7 µM -0.420363857425771 0.33353845713006 no 2234 0.337109833470041 700 1203031 SGTC_423 5-fluorouracil 457 µM -0.42061150794141 0.333452015575974 no 2235 0.337019394517982 718 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_957 1187-1561 14.1 µM -0.425156277380618 0.331867253808836 no 2236 0.335361377427353 733 1538454 SGTC_2676 harmalol 100 µM -0.42524191229284 0.331837421646707 no 2237 0.335330166839719 717 5459187 A monoamine oxidase inhibitor SGTC_96 0929-0093 37.281 µM -0.425307081030533 0.331814719887356 no 2238 0.335306416136516 720 6991579 SGTC_1546 5-methoxyflavanone 78.7 µM -0.425749415503774 0.331660647440043 no 2239 0.335145225033268 715 147795 SGTC_1348 1493-0373 93.8 µM -0.42594240672775 0.331593434309915 no 2240 0.335074906611345 748 3010129 SGTC_136 0097-0015 404.482 µM -0.426342221732799 0.331454207832981 no 2241 0.334929248120475 728 4861337 SGTC_2248 tofa 1.1 µM -0.427376702451486 0.331094081579306 no 2242 0.334552486836132 733 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1556 plumbagin 1.48 µM -0.427988496665186 0.330881175584812 no 2243 0.334329747715297 740 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1813 st051246 8.6015 µM -0.428679490710779 0.330640773606599 no 2244 0.334078244027631 717 5291959 SGTC_721 1187-1332 279 µM -0.429502935589223 0.330354382215394 no 2245 0.333778628996571 736 25730 SGTC_173 1273-0061 2.693 µM -0.431528837502923 0.329650203388495 no 2246 0.333041944555973 733 2847414 YPL266W DIM1 SGTC_2101 5377231 179.231 µM -0.433341174243247 0.329020768497055 no 2247 0.332383464886476 745 2844213 SGTC_2089 5281248 129.67 µM -0.433468583646669 0.328976536691368 no 2248 0.332337192419321 712 2737878 SGTC_463 ikarugamyin 104 µM -0.433956014793038 0.328807340837842 no 2249 0.332160191076031 748 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1710 st031758 61.5 µM -0.435055572618484 0.328425794000469 no 2250 0.331761045108 743 5394341 SGTC_1837 st055472 66.5 µM -0.435388520371976 0.328310296308748 no 2251 0.331640220746958 727 676091 SGTC_2167 5876490 200 µM -0.435401760316318 0.328305703786117 no 2252 0.331635416427745 765 686534 SGTC_2583 asiatic acid 100 µM -0.43553761239547 0.32825858244754 no 2253 0.331586121993313 758 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3265 9137266 49.47 µM -0.43601173362728 0.328094151263838 no 2254 0.331414108189435 707 17224265 SGTC_1496 4469-0713 57.4 µM -0.436532509314047 0.327913578116808 no 2255 0.331225208868235 762 746691 SGTC_383 2324-0395 7.37 µM -0.436738567852121 0.327842140726328 no 2256 0.331150477758899 744 3146421 SGTC_1310 1188-0297 994 nM -0.43783564701218 0.327461906014822 no 2257 0.33075271408799 729 1588352 SGTC_2713 st079149 53.4 µM -0.438652189759147 0.327179018027752 no 2258 0.33045678737178 713 3103253 SGTC_2086 5274770 176.623 µM -0.439538986656732 0.32687190319167 no 2259 0.330135519601138 731 689278 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.442134241813745 0.325973790598892 no 2260 0.329196033619516 734 140250 A respiratory chain inhibitor. SGTC_2400 5203494 178.7 µM -0.443763473860487 0.3254104944381 no 2261 0.328606799507507 737 6777674 SGTC_2589 lobaric acid 100 µM -0.443857779668207 0.325377901023111 no 2262 0.328572705545352 729 73157 A novel microtubule depolymerizer. SGTC_1553 gossypol 38.6 µM -0.444306214309006 0.325222933975243 no 2263 0.328410604481364 725 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1135 dihydrocapsaicin 536.708 nM -0.444966383278985 0.324994852192137 no 2264 0.32817202403602 749 107982 A Capsaicinoid. SGTC_2915 7971052 15.16 µM -0.445318329009515 0.324873285249865 no 2265 0.328044861943321 745 5741558 SGTC_283 0987-0079 11.7 µM -0.445435442616694 0.324832836718008 no 2266 0.328002551851017 730 411556 SGTC_2480 5767542 37.17 µM -0.451558007869278 0.322721119498911 no 2267 0.325793713530712 715 2867358 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.456128380490522 0.321148478392934 no 2268 0.324148831461456 743 616764 SGTC_1725 st036284 20.55 µM -0.456915436053586 0.320877979152892 no 2269 0.323865914292098 717 707914 SGTC_2875 9039966 71.43 µM -0.458141344700168 0.320456842032822 no 2270 0.323425448447921 744 6463691 SGTC_1077 5-fluorocytosine 377 nM -0.458311413753481 0.320398436350854 no 2271 0.323364362594422 770 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_746 1095-0025 46.6 µM -0.459075714899359 0.320136012430493 no 2272 0.323089897680102 759 6749286 SGTC_2335 9018011 154.17 µM -0.460012886010676 0.319814356128143 no 2273 0.322753485599933 726 6458208 SGTC_1090 efavirenz 20.7 µM -0.46271941129849 0.318886182363584 no 2274 0.321782751320201 727 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1081 sertraline 6 µM -0.463808244451868 0.318513098469538 no 2275 0.321392568015316 751 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_514 4466-0038 2.65 nM -0.464221782380346 0.318371449692672 no 2276 0.321244428317818 748 5722064 SGTC_2451 5856223 45.7 µM -0.466209099293139 0.317691106466593 no 2277 0.320532918399396 744 2179896 SGTC_2363 9053361 176 µM -0.466244129985142 0.31767911947927 no 2278 0.320520382425406 764 6469797 YMR079W SEC14 SGTC_1194 1488-0194 225 µM -0.467944347255929 0.317097560084876 no 2279 0.319912194338874 732 1391452 SGTC_1811 st050069 61.5 µM -0.468429963839525 0.316931537734449 no 2280 0.319738572213797 759 3877702 SGTC_2608 thymoquinone 42.66 µM -0.46923266131923 0.316657192744017 no 2281 0.319451671000668 757 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3082 9117008 49.47 µM -0.469331943736196 0.316623267120856 no 2282 0.31941619285073 736 41448529 SGTC_1057 3448-5381 134 µM -0.469707540269685 0.316494936636407 no 2283 0.319281989983967 742 5497911 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.471795212357707 0.315782042364237 no 2284 0.318536484278792 757 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_809 3998-0021 90 µM -0.473401015025824 0.31523416166882 no 2285 0.31796355292386 768 715485 SGTC_2246 7293507 91.5585 µM -0.474291471717969 0.314930523434599 no 2286 0.317646036108608 767 887656 SGTC_2131 toluylene red 5.2905 µM -0.474435702932256 0.314881353566982 no 2287 0.317594619115333 720 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2289 7946404 165.07 µM -0.475208003255516 0.314618124480558 no 2288 0.317319361609163 732 1246120 YPR165W RHO1 SGTC_3100 9120536 49.47 µM -0.477149458089473 0.313956819666255 no 2289 0.316627849170418 765 16421196 SGTC_375 3970-0961 9.27 µM -0.479175951930485 0.313267185372765 no 2290 0.315906730326753 742 2898222 SGTC_1226 3909-7979 35.4 µM -0.479535189061433 0.313145001728116 no 2291 0.315778970354913 753 6615510 SGTC_1305 1181-0477 144 µM -0.479833869686798 0.313043430164215 no 2292 0.315672763601314 741 6252086 SGTC_1900 st060200 72.8 µM -0.481414470959224 0.312506155422064 no 2293 0.315110976926308 729 688945 SGTC_2881 9058953 51.95 µM -0.482577789718085 0.312110976847382 no 2294 0.314697776203339 722 17122249 SGTC_1105 epirubicin 18.1 µM -0.483323146499373 0.311857893223401 no 2295 0.314433153810658 740 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1049 3226-0134 66 µM -0.483970009384295 0.311638324877943 no 2296 0.314203576739557 749 5702385 SGTC_1279 0874-0590 65.2 µM -0.485208011134044 0.311218289646752 no 2297 0.313764399955093 746 3523074 SGTC_2340 7987427 183.45 µM -0.485379098287519 0.311160261680589 no 2298 0.313703728116588 753 2239331 SGTC_1174 0739-0097 51.1 µM -0.487622819141559 0.310399689283688 no 2299 0.312908514659915 755 728447 SGTC_168 3970-0862 530.542 µM -0.489546726809475 0.309748171413037 no 2300 0.312227340885044 764 3135186 SGTC_1383 3049-0032 20.7 µM -0.491146652380489 0.309206822498833 no 2301 0.311661363661212 772 712864 SGTC_946 3434-1334 87.4 µM -0.491987591807095 0.308922449125443 no 2302 0.311364057647181 737 4047976 SGTC_152 4469-0003 551.229 µM -0.493876510345948 0.30828410713332 no 2303 0.310696697338239 755 697280 SGTC_527 4476-4215 268 µM -0.494287440616231 0.308145313826145 no 2304 0.310551596853058 732 4418754 SGTC_921 1561-0023 372 µM -0.495557339847356 0.307716573815532 no 2305 0.310103378656104 767 24050882 SGTC_874 0599-0792 117 µM -0.497469266423069 0.307071569355417 no 2306 0.309429085266068 789 765305 SGTC_1530 rhein 70.4 µM -0.498376250966155 0.306765799006517 no 2307 0.309109436332048 745 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_606 k015-0008 38.6 µM -0.498997236046372 0.306556524732015 no 2308 0.308890665604144 785 1970475 SGTC_1086 cerivastatin 2.18 µM -0.500037134657938 0.30620621628773 no 2309 0.308524465021881 745 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_842 0271-0008 11.1 µM -0.500118541618061 0.306178800368392 no 2310 0.308495805569378 758 1221709 SGTC_959 1222-0044 107 µM -0.505378040852501 0.304409832629622 no 2311 0.306646669569338 764 6083612 SGTC_189 3970-0742 2.116 µM -0.505957992709181 0.304215051744434 no 2312 0.306443069733346 776 2891807 SGTC_777 1315-0167 517 µM -0.50654113658571 0.304019254794535 no 2313 0.306238409524152 743 4221767 SGTC_537 1334-0398 209 µM -0.506948489049197 0.303882515074934 no 2314 0.306095480935807 763 5846986 SGTC_1228 0124-0032 52.5 µM -0.507162688243456 0.303810623882182 no 2315 0.306020336266716 742 X1228 SGTC_166 k072-0058 166.424 µM -0.508342717057552 0.303414709589555 no 2316 0.305606508793297 782 5846229 SGTC_165 k038-0023 64.381 µM -0.508439710636685 0.30338217729643 no 2317 0.305572504886115 756 46368543 SGTC_2033 5192550 145 µM -0.508512907838439 0.30335762749895 no 2318 0.305546844598163 728 182073 SGTC_657 3534-0529 86.7 µM -0.510393019526825 0.302727356531482 no 2319 0.304888073149207 774 1049549 SGTC_504 lovastatin 124 µM -0.510677534708988 0.302632029456745 no 2320 0.304788437009601 786 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1267 0828-0272 9.49 µM -0.511174544652987 0.302465538095939 no 2321 0.304614420742468 760 745334 SGTC_1071 trifluoperazine 6.31 µM -0.512071021855438 0.302165334702639 no 2322 0.304300652268739 790 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2619 obliquin 87.91 µM -0.512604281947185 0.301986825317417 no 2323 0.304114078667596 770 6708593 A bioactive alkalod. YER133W GLC7 SGTC_56 0957-0365 83.25 µM -0.512941967390194 0.301873809255947 no 2324 0.303995957830369 754 6752360 SGTC_2216 7189485 200 µM -0.513206891894907 0.30178515802355 no 2325 0.303903302760028 751 731273 SGTC_997 3996-0078 137 µM -0.515478257205849 0.301025575735294 no 2326 0.303109429715485 764 735687 SGTC_2250 alverine citrate 130 µM -0.516123274909626 0.300810028319512 no 2327 0.302884156489529 765 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.516976907852254 0.300524874451249 no 2328 0.302586139428123 806 65057 A dermal irritant. YDR527W RBA50 SGTC_2997 9067075 71.4286 µM -0.517616543296033 0.300311285930995 no 2329 0.302362918520531 770 27209819 SGTC_478 N-arachidonylglycine 10 µM -0.517773382341813 0.300258924356121 no 2330 0.302308195880291 737 5283389 SGTC_451 chloral hydrate 100 µM -0.517957611133753 0.300197423835942 no 2331 0.302243922371718 796 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1581 himbacine 57.9 µM -0.518207894362623 0.300113881696248 no 2332 0.302156613700235 782 5281825 An alkaloid muscarinic receptor antagonist. SGTC_421 streptovitacin 30 mM -0.518716414549434 0.299944174932979 no 2333 0.301979256661368 768 91467 include heat shock SGTC_577 r071-0003 38.6 µM -0.519043719647956 0.299834967460871 no 2334 0.301865126911214 770 4568517 YMR134W ERG29 SGTC_2240 6690706 185.951 µM -0.520026403534084 0.299507196810818 no 2335 0.301522586176195 734 805876 SGTC_1297 1068-0111 14.1 µM -0.52124351243905 0.299101459858302 no 2336 0.301098572963204 769 767057 SGTC_827 3253-0474 693 µM -0.521764071242766 0.298928001935384 no 2337 0.300917304126816 781 5402065 SGTC_439 amiodarone 34.4 µM -0.521857237135881 0.298896962497833 no 2338 0.30088486711898 756 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1205 4161-2785 76 µM -0.523330998461953 0.298406154511001 no 2339 0.30037196643289 778 3498106 SGTC_730 1436-0052 41.2 µM -0.524092241674626 0.298152780778768 no 2340 0.300107192223772 742 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_263 alizarin 107.927 µM -0.524211820293862 0.298112988896776 no 2341 0.300065610204401 783 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_3280 9140961 49.47 µM -0.524808909208942 0.297914333304972 no 2342 0.299858018761049 780 4901226 SGTC_1243 0416-0003 5.65 µM -0.525979452232195 0.297525060826993 no 2343 0.29945124183357 776 2141977 SGTC_3338 9144300 39.5675 µM -0.526039003600317 0.297505262801579 no 2344 0.299430553749564 768 4901274 SGTC_2237 6667747 47.222 µM -0.527174810764706 0.297127775608155 no 2345 0.299036099625064 758 729940 YDL015C TSC13 SGTC_2000 st075254 36.4 µM -0.529309351774703 0.296418950897522 no 2346 0.298295434647764 732 17234175 SGTC_3013 9080133 71.4286 µM -0.529491438879627 0.296358520473903 no 2347 0.298232290874124 760 17050193 SGTC_1324 1418-0026 34.4 µM -0.529738486325578 0.2962765402739 no 2348 0.298146630026469 782 1372513 SGTC_294 k038-0071 157 µM -0.530172701974317 0.296132475405847 no 2349 0.297996097935205 768 24152826 SGTC_1688 st021091 57.6 µM -0.531654769063114 0.295640994713679 no 2350 0.29748256211818 792 3656366 SGTC_758 0868-0029 16 µM -0.531798464350376 0.295593362659607 no 2351 0.29743279323935 739 762687 SGTC_2114 5491910 81.25 µM -0.534925048040075 0.29455783869766 no 2352 0.296350843498203 778 2849228 SGTC_2488 5268135 45.7 µM -0.538058225932911 0.293521813089391 no 2353 0.295268425605933 787 1270356 YLR208W SEC13 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.538179999569687 0.293481581158956 no 2354 0.29522639326847 777 75037 A free radical scavenger. SGTC_2367 9070478 135.38 µM -0.53879057438265 0.293279896185854 no 2355 0.295015684047487 764 572802 SGTC_153 4077-0274 519.67 µM -0.538873098087196 0.29325264189809 no 2356 0.294987210452315 752 3121976 SGTC_2617 dihydrotanshinone i 20.83 µM -0.539180752270926 0.293151046342102 no 2357 0.294881070044137 776 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_246 cycloheximide 667 µM -0.541308434395719 0.292448876552212 no 2358 0.294147503962212 770 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2759 disulfiram 3.38 µM -0.541420859299812 0.292411796257902 no 2359 0.294108766424153 757 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_413 propylparaben 100 µM -0.54222993976458 0.292145007581784 no 2360 0.29383005624992 776 7175 A pharmaceutical preservative. SGTC_2003 4023581 200 µM -0.543557094994477 0.291707632803388 no 2361 0.293373145655921 756 16641307 SGTC_2247 cerulenin 830 nM -0.545695658144399 0.291003494773011 no 2362 0.292637578498081 744 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1345 1488-0192 31.4 µM -0.546684475683074 0.290678187839356 no 2363 0.292297760740262 790 658348 SGTC_817 1391-0715 46 µM -0.546744401991261 0.290658478402331 no 2364 0.292277172321157 796 1353946 SGTC_196 k015-0023 18.111 µM -0.547577786542301 0.290384447571457 no 2365 0.291990922767232 766 5211998 SGTC_1028 k015-0029 4.8 µM -0.548640885620435 0.290035058423807 no 2366 0.291625960820781 790 4588309 SGTC_2427 5545055 42.75 µM -0.551200421790246 0.28919467230376 no 2367 0.290748145482122 768 5372858 SGTC_598 3937-0236 20.2 µM -0.551275311255832 0.289170100694399 no 2368 0.290722480099399 795 1379313 SGTC_247 mechlorethamine 29.705 µM -0.552291194250027 0.288836881397891 no 2369 0.290374431363314 760 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2595 hexamethylquercetagetin 100 µM -0.553031720948177 0.288594095540852 no 2370 0.290120844658635 800 386331 SGTC_1024 4507-0395 26 µM -0.556546055127552 0.287443214018725 no 2371 0.288918809795335 745 4201836 SGTC_3292 9120825 59.784 µM -0.557431424321179 0.287153614137682 no 2372 0.288616350126585 799 24824900 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.557663816576927 0.287077622673736 no 2373 0.288536985045064 777 94937 An inhibitor of serotonin biosynthesis. SGTC_1885 st057546 99.9 µM -0.559368663471378 0.286520435023144 no 2374 0.287955071565584 768 702008 SGTC_1862 st057513 3.81 µM -0.561213461953387 0.285918086202031 no 2375 0.287326013442044 790 5393163 SGTC_2890 9046729 58.44 µM -0.561993266107167 0.28566365193771 no 2376 0.287060303549663 780 903329 SGTC_138 0850-0259 40.9225 µM -0.563757666772868 0.285088361789208 no 2377 0.286459532851229 774 6813004 SGTC_289 k017-0060 526 µM -0.563757735824615 0.285088339285412 no 2378 0.286459509351091 788 5512909 SGTC_2968 9090663 33.37 µM -0.56559021350353 0.284491437684961 no 2379 0.285836191068275 796 25236811 SGTC_3016 9080866 49.47 µM -0.566084346866956 0.284330583545147 no 2380 0.285668221807135 795 17066299 SGTC_2185 6113692 200 µM -0.566709694798393 0.284127077752142 no 2381 0.285455716524341 791 874150 SGTC_3045 9092950 49.47 µM -0.572147655772148 0.282360355549329 no 2382 0.283610972928005 783 44120432 SGTC_2127 5253358 187.912 µM -0.572724410706387 0.282173285856801 no 2383 0.283415653286519 780 20612 SGTC_739 1486-1183 203 µM -0.575032720821407 0.281425186331558 no 2384 0.282634583893305 778 4346692 SGTC_2959 9079155 11 µM -0.578060005460094 0.280445527592557 no 2385 0.281611803886912 812 16189457 SGTC_1457 k015-0032 57.3 µM -0.57928024473497 0.280051113669259 no 2386 0.281200046580312 809 4302660 SGTC_1155 4088-0394 48.2 µM -0.579810451745768 0.279879820438401 no 2387 0.281021224281195 788 2326248 SGTC_971 1315-0384 26.7 µM -0.58243178368527 0.2790336978497 no 2388 0.280137938989671 810 6769120 SGTC_350 k064-0020 19.8 µM -0.583376307125375 0.278729126475122 no 2389 0.279820001947276 797 2790705 SGTC_996 3970-0799 1.8 µM -0.584522014425313 0.278359898631617 no 2390 0.279434579278129 778 6615648 YGL040C HEM2 SGTC_1617 st002906 78 µM -0.58734434959457 0.277451361044451 no 2391 0.278486230544179 782 5150859 SGTC_916 4466-0038 42 nM -0.58948203247355 0.276764185898821 no 2392 0.277768980830842 798 5722064 YGL116W CDC20 SGTC_941 3237-0776 460 µM -0.590108590737741 0.276562931887362 no 2393 0.27755892487096 796 760008 SGTC_236 1509-0011 5.31 µM -0.590141371888101 0.276552404374102 no 2394 0.277547937007015 822 3107280 SGTC_1151 3909-8316 15.3 µM -0.590911299750294 0.276305202145848 no 2395 0.277289927199181 792 800431 SGTC_1246 0422-0085 105 µM -0.591607816449769 0.276081663618568 no 2396 0.277056619240878 809 264295 SGTC_234 nsc-17383 10.7 µM -0.592564953452062 0.275774627101146 no 2397 0.276736169696003 785 408974 SGTC_1805 st050013 60.3 µM -0.593744916133363 0.275396342244491 no 2398 0.276341368186189 794 4037144 SGTC_1936 st074407 74.3 µM -0.595358881913651 0.274879333904117 no 2399 0.275801802212952 784 809813 SGTC_1655 st012546 55.1 µM -0.595654461225009 0.274784701609173 no 2400 0.275703043012904 791 720985 YLR208W SEC13 SGTC_25 0118-0223 35.662 µM -0.596076413228542 0.274649637829578 no 2401 0.275562090192935 806 5333628 SGTC_722 3534-0461 190 µM -0.596987659857064 0.274358066138993 no 2402 0.275257809747911 786 658262 SGTC_881 0833-0569 170 µM -0.598736005122515 0.273799076084435 no 2403 0.274674471585535 765 5418700 SGTC_2493 resveratrol 26.09 µM -0.599879928571147 0.273433639982831 no 2404 0.274293129945455 776 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_314 1671-0008 2.74 µM -0.599957693785106 0.273408805990719 no 2405 0.274267215400652 815 3913060 SGTC_2264 7948757 110.76 µM -0.600983785921973 0.273081232428497 no 2406 0.27392539286262 799 2971411 SGTC_3155 9099265 49.47 µM -0.601916260123903 0.272783714620542 no 2407 0.273614940066568 809 25236499 SGTC_282 k297-0036 65.7 µM -0.602057878465248 0.272738543549093 no 2408 0.273567805673297 801 5061378 SGTC_338 4055-0136 114 µM -0.602238856959714 0.272680823430837 no 2409 0.273507577011617 791 2900563 SGTC_2066 5222451 176 µM -0.602907789891589 0.272467530886452 no 2410 0.273285016738872 801 2281147 SGTC_2034 5197015 53.07 µM -0.603846373806891 0.272168398550991 no 2411 0.27297289236009 816 780676 SGTC_2739 tacrine 100.86 µM -0.603862523033532 0.272163253124228 no 2412 0.272967523511169 788 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1264 0783-0040 158 µM -0.6049080980539 0.27183021753511 no 2413 0.272620031071692 794 2855798 SGTC_1449 4112-4002 201 µM -0.605931414848999 0.271504468081717 no 2414 0.272280148803015 791 2059539 SGTC_3101 9120531 49.47 µM -0.606156075103851 0.271432978675248 no 2415 0.272205558818852 833 24824904 SGTC_1413 3910-0535 34.4 µM -0.60733087305732 0.271059297630308 no 2416 0.271815676843473 795 2876951 SGTC_320 4092-0846 5.34 µM -0.607484575140887 0.271010426888134 no 2417 0.271764688063855 803 1359356 SGTC_345 1362-0200 395 µM -0.609442616029465 0.270388237874861 no 2418 0.271115548915274 803 1419823 SGTC_372 0155-0182 15.9 µM -0.611886793711951 0.269612576702642 no 2419 0.270306329871597 783 771486 SGTC_3157 9099274 49.47 µM -0.612425339400924 0.269441818925323 no 2420 0.270128190492554 802 17217662 SGTC_336 4111-0029 111 µM -0.61386542583487 0.268985474254083 no 2421 0.269652129397428 818 3131175 SGTC_1578 josamycin 24.2 µM -0.614363373950795 0.268827771287899 no 2422 0.269487616478936 804 5282165 A P450 substrate. SGTC_799 1310-0557 151 µM -0.617032550075566 0.26798322056599 no 2423 0.268606628105769 820 5354492 SGTC_1422 4031-0024 15.5 µM -0.618757280623166 0.267438212128147 no 2424 0.268038134287179 820 782427 SGTC_1525 8-methoxypsoralen 92.5 µM -0.618900994468917 0.267392824331761 no 2425 0.267990791671493 829 4114 Related to psoralen; DNA damaging agent. SGTC_2702 st077768 96.8 µM -0.619648926182388 0.267156674819547 no 2426 0.26774447391491 783 6484119 SGTC_110 0850-0284 111.64 µM -0.621880930700043 0.266452575450394 no 2427 0.267010082507892 790 3906265 SGTC_1451 4152-0210 104 µM -0.625460593073685 0.265325312644515 no 2428 0.265834402138422 826 659563 SGTC_2769 toremifene 3.73 µM -0.62723118032351 0.264768637464925 no 2429 0.265253853634757 800 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2483 5729050 27.16 µM -0.628637427288576 0.264326934900219 no 2430 0.26479322581721 821 2865180 SGTC_1693 xanthone 101.9 µM -0.629581833054064 0.264030507502211 no 2431 0.264484106330336 828 7020 An insecticide. SGTC_1572 epiandrosterone 68.9 µM -0.631274126078824 0.263499759434099 no 2432 0.263930650812409 805 441302 A steroid. SGTC_791 1348-1292 225 µM -0.631971672249083 0.263281149004919 no 2433 0.26370269394873 815 5437054 SGTC_2975 9084847 53.72 µM -0.633840155289124 0.262696024578131 no 2434 0.263092572152089 774 27211724 SGTC_2525 harmine 47.85 µM -0.633912615023781 0.262673346872058 no 2435 0.263068926178408 799 5280953 A monoamine oxidase inhibitor SGTC_2368 9071271 200 µM -0.635824478345702 0.262075353541499 no 2436 0.262445415465538 821 27209959 SGTC_3345 9148410 3.559 µM -0.636433775742577 0.261884923997472 no 2437 0.262246866090613 815 4903596 SGTC_2196 6573537 42.6665 µM -0.637063484856059 0.261688189577319 no 2438 0.262041746118864 829 2903087 SGTC_3315 9136395 68.55 µM -0.638021498937256 0.261389031272034 no 2439 0.261729842662246 841 16876844 SGTC_2753 fluvastatin 17.09 µM -0.639267401168665 0.261000237272876 no 2440 0.26132449574266 829 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1079 idarubicin 2.36 µM -0.639354344546628 0.26097311698252 no 2441 0.261296221270626 838 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1748 st037455 53.6035 µM -0.639382008225926 0.260964488141419 no 2442 0.261287225217223 820 580690 SGTC_2438 5259590 200 µM -0.640348804947497 0.26066301757383 no 2443 0.260972929023834 811 1201127 SGTC_2361 9034121 116 µM -0.641325870663153 0.260358527099422 no 2444 0.260655492107758 842 6496917 SGTC_2331 7980721 200 µM -0.64276393922979 0.259910704310742 no 2445 0.26018864266876 808 2981221 SGTC_488 nitrendipine 139 µM -0.643088750257992 0.259809611329044 no 2446 0.260083256870742 810 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2013 4024628 200 µM -0.643209199223288 0.259772128396412 no 2447 0.260044182479253 835 5230760 SGTC_911 3456-4043 236 µM -0.643259635529924 0.259756433775578 no 2448 0.260027821527675 809 914281 SGTC_2795 7780010 54.55 µM -0.64520160643688 0.259152509363481 no 2449 0.259398272649727 811 953673 SGTC_1115 galangin 695.678 nM -0.645803454836213 0.258965490803348 no 2450 0.25920332515106 836 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2443 5493264 126.67 µM -0.646173304666133 0.258850598191903 no 2451 0.259083562960851 825 5340055 SGTC_1277 0873-0036 22 µM -0.646336451659731 0.258799925508973 no 2452 0.259030742935965 816 5965735 SGTC_1771 st048882 4.1505 µM -0.646878533569881 0.258631594309242 no 2453 0.258855279978741 797 4580403 SGTC_188 3229-0966 278.469 µM -0.64774564984418 0.258362448995017 no 2454 0.258574736685708 818 5722370 SGTC_3321 9137793 26.8275 µM -0.648011477874402 0.258279967372257 no 2455 0.258488763302986 816 4904192 SGTC_2405 ticlatone 3.52 µM -0.648107146905222 0.258250286344803 no 2456 0.258457825907268 796 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1132 3456-3614 2.5 µM -0.650126500864953 0.257624200633174 no 2457 0.257805256202789 814 3125502 SGTC_2078 5212016 200 µM -0.650818733211408 0.257409760672935 no 2458 0.257581752986936 820 1899708 SGTC_217 ketoconazole 989 nM -0.651147452122173 0.257307962509207 no 2459 0.257475653736411 794 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2217 6934799 96.0675 µM -0.651967366368924 0.257054141451679 no 2460 0.2572111123579 798 675606 SGTC_1492 4158-0558 28.5 µM -0.652672207811961 0.256836047651658 no 2461 0.256983811665598 790 3967268 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.654980919049201 0.256122355363814 no 2462 0.256240019614916 814 66535 A nucleotide analog. SGTC_588 3970-1144 52.9 µM -0.658718672814823 0.254969099405614 no 2463 0.255038219964307 790 1888707 SGTC_1714 st033236 13.627 µM -0.658759861916636 0.254956405969516 no 2464 0.255024992881469 823 2916566 SGTC_1477 0139-0234 16 µM -0.658870344417722 0.254922359699023 no 2465 0.25498951533709 820 620880 SGTC_661 1304-0007 33.6 µM -0.660263019452484 0.254493397279433 no 2466 0.254542528574942 811 3117130 SGTC_1974 st069448 26.9 µM -0.662121491828463 0.253921552732184 no 2467 0.253946681581107 805 6323587 YNR016C ACC1 SGTC_3090 9117696 49.47 µM -0.662219707338283 0.253891350982367 no 2468 0.253915212967391 804 7923821 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.663019505975651 0.253645479195437 no 2469 0.25365903072566 817 115019 SGTC_114 0364-0001 490.298 µM -0.664204847603149 0.253281315039205 no 2470 0.253279605638443 822 4003655 SGTC_1769 st044406 64.4 µM -0.66510888430416 0.253003759099799 no 2471 0.252990426303705 844 670903 SGTC_449 xestospongin c 11.1929 µM -0.666104200392739 0.252698363899689 no 2472 0.252672249958779 833 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_886 0866-0150 153 µM -0.667514814704163 0.252265874524387 no 2473 0.252221674964842 813 271463 SGTC_167 3672-0051 66.205 µM -0.671504199414622 0.251044859083875 no 2474 0.250949692572923 811 3237971 SGTC_2630 antimycin a 100 µM -0.672992774729267 0.250590058985435 no 2475 0.250475943794028 835 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1023 4482-3888 16 µM -0.673941715310398 0.250300359899393 no 2476 0.250174184830163 829 3303168 SGTC_1727 st034309 9.9045 µM -0.673944012542117 0.250299658800258 no 2477 0.250173454554524 840 870305 SGTC_902 1120-0002 2.07 µM -0.675319568773983 0.249880035646706 no 2478 0.249736376908972 816 3280475 SGTC_1147 3809-1045 12.3 µM -0.677035926643733 0.249356972658222 no 2479 0.249191580025656 816 325925 SGTC_1266 0828-0227 32.9 µM -0.677469055825582 0.249225067832878 no 2480 0.249054198485577 840 3913820 SGTC_3214 9129694 49.47 µM -0.677757162427425 0.249137348625204 no 2481 0.248962838073257 837 17158655 SGTC_784 4579-0127 173 µM -0.678207089304084 0.249000393195973 no 2482 0.248820199117316 831 1948547 SGTC_1772 st048439 82.2 µM -0.680241019896086 0.248381775390337 no 2483 0.248175931517213 811 2927068 YDL195W SEC31 SGTC_1113 artemisinin 1.17947 µM -0.683593448159629 0.247363928504747 no 2484 0.24711596152628 832 2240 An anti-malaria and mitochondrial poison. SGTC_2012 4023501 200 µM -0.683872237210388 0.247279384546335 no 2485 0.247027923259445 850 3477460 SGTC_3270 9137563 49.47 µM -0.686058585045799 0.246616901302242 no 2486 0.246338082815968 810 17015724 SGTC_1415 3966-0071 78.1 µM -0.686228006692991 0.246565604721885 no 2487 0.246284669732944 833 2893185 SGTC_2386 9075165 157.42 µM -0.688205461718399 0.24596730437941 no 2488 0.2456617025029 827 16452277 SGTC_295 k015-0027 31 µM -0.688245936849226 0.245955066332933 no 2489 0.245648960270123 835 3887424 SGTC_3133 9127736 49.47 µM -0.68827554069366 0.245946115531713 no 2490 0.245639640720751 819 27243420 SGTC_154 3389-1638 511.116 µM -0.688295158875684 0.245940184018421 no 2491 0.245633464849931 860 5238686 SGTC_1741 st038134 10.228 µM -0.689620932010808 0.245539517424695 no 2492 0.245216300236393 829 1272587 SGTC_718 1130-0073 349 µM -0.689898043383149 0.245455814943638 no 2493 0.245129153189917 838 6740020 SGTC_2344 7990960 76.95 µM -0.692108052852096 0.244788822736107 no 2494 0.244434737447722 837 140813 SGTC_1807 st050092 58.9 µM -0.692796000904604 0.244581395781339 no 2495 0.244218791122648 832 5008496 SGTC_535 2293-4129 48.2 µM -0.69280099240471 0.244579891113037 no 2496 0.244217224670827 855 396118 YIL048W NEO1 SGTC_1482 3346-2049 8.48 µM -0.697424167561894 0.243188396173457 no 2497 0.242768690701113 816 3826804 SGTC_1162 k048-0130 20.1 µM -0.697935574178787 0.243034735063319 no 2498 0.242608742845188 837 6797406 SGTC_358 0075-0058 9.45 µM -0.700628737366861 0.242226393976892 no 2499 0.241767369716869 879 1069125 SGTC_2156 5649887 115 µM -0.700888414719817 0.242148530067521 no 2500 0.241686327510549 844 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_190 3970-0790 3.722 µM -0.702173035323459 0.241763537973471 no 2501 0.241285629738912 830 2832352 SGTC_3025 9087895 49.47 µM -0.703041814467738 0.241503359166709 no 2502 0.241014845646114 842 17173641 SGTC_2288 7946289 167.31 µM -0.704083655732361 0.241191552974001 no 2503 0.240690338987242 844 1246052 SGTC_2176 5809774 33.9695 µM -0.708153884734093 0.239975499480913 no 2504 0.239424850092584 815 2870539 SGTC_2650 prasterone 100 µM -0.7105167133339 0.239271099047972 no 2505 0.238691885198292 818 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_391 gliotoxin 8.33 µM -0.710520273857719 0.239270038446769 no 2506 0.238690781627743 852 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2429 5902844 64.44 µM -0.71195793083666 0.238842002230157 no 2507 0.23824541364706 841 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_95 0471-0001 561.058 µM -0.713455789952027 0.238396487782299 no 2508 0.237781880453462 830 4015405 SGTC_1018 4259-0013 28.1 µM -0.713657923659342 0.238336401183997 no 2509 0.237719365288429 843 6801262 SGTC_2327 6189656 200 µM -0.71396768232355 0.238244337910915 no 2510 0.237623581772971 852 5349088 SGTC_2693 st077581 40.7 µM -0.714407194662357 0.23811374402805 no 2511 0.237487712199691 837 25238761 SGTC_849 0386-0493 241 µM -0.714459683490348 0.238098150456365 no 2512 0.237471488806187 850 726119 SGTC_2806 7952793 58.44 µM -0.714590241799018 0.238059366147147 no 2513 0.237431138118322 851 2972490 SGTC_987 1497-1013 404 µM -0.716282928275596 0.237556841766973 no 2514 0.236908332968682 837 1676435 SGTC_266 formosanin C 406 nM -0.716352497520066 0.237536200528155 no 2515 0.236886859277634 831 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3208 9114115 49.47 µM -0.717171326882499 0.237293327329435 no 2516 0.236634194569047 838 650895 SGTC_2780 5215298 71.43 µM -0.718604962236196 0.236868424979082 no 2517 0.236192177528795 863 2834131 SGTC_2200 6600604 21.907 µM -0.719745705343233 0.236530629413941 no 2518 0.235840789876139 867 2904777 SGTC_3065 9113888 49.47 µM -0.724978565633798 0.23498448303112 no 2519 0.234232590066007 836 16648368 SGTC_2977 9011197 71.43 µM -0.725971593645811 0.23469170602536 no 2520 0.233928092444837 847 2704722 SGTC_1520 flindersine 88 µM -0.726676845767193 0.234483897280503 no 2521 0.233711970376597 854 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2754 granisetron 64.02 µM -0.728735792561771 0.233877793301531 no 2522 0.233081646985743 847 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1996 st072960 66.8 µM -0.729266878502724 0.23372159544349 no 2523 0.232919214272576 831 1719405 SGTC_1531 st059297 52.4 µM -0.732307964567415 0.232828295151044 no 2524 0.231990309574341 857 7566702 SGTC_2477 5967686 25.23 µM -0.733081788638546 0.23260129223674 no 2525 0.231754273390741 851 776118 SGTC_1720 st037298 9.481 µM -0.735012910387568 0.232035330645777 no 2526 0.231165815735947 862 597396 SGTC_1590 st077108 57.8 µM -0.735049356347518 0.23202465665867 no 2527 0.231154717827111 835 5489485 SGTC_3302 9125395 16.351 µM -0.735803266962689 0.231803918967077 no 2528 0.230925216378974 840 17599668 SGTC_270 tamoxifen 5.46 µM -0.736031472788302 0.231737125594197 no 2529 0.230855772269848 871 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_734 2023-0417 80 µM -0.736474608720284 0.23160745514162 no 2530 0.230720957230486 859 3935732 SGTC_910 3454-3003 490 µM -0.736551660781705 0.231584912292534 no 2531 0.230697520206735 854 820824 SGTC_2834 9001755 58.44 µM -0.73675598566128 0.231525139607093 no 2532 0.230635376887847 858 2989575 SGTC_2616 abietic acid 100 µM -0.737036710375338 0.231443031133669 no 2533 0.230550012596836 857 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3354 9151612 71.43 µM -0.738542542377245 0.231002871324222 no 2534 0.230092412566221 831 27261949 SGTC_1611 st001856 99.4 µM -0.739740483006881 0.230653043203311 no 2535 0.22972873939926 862 647478 SGTC_1991 st073000 8.92 µM -0.740880111665552 0.23032051852412 no 2536 0.229383067684122 862 4301969 YIL048W NEO1 SGTC_595 3909-8003 73.7 µM -0.741129630064347 0.230247748995541 no 2537 0.229307422784938 860 699517 SGTC_2061 5245884 80.95 µM -0.741460209232544 0.230151358716529 no 2538 0.229207224752001 860 573863 SGTC_1192 1488-0095 21.4 µM -0.741953544354067 0.230007554044775 no 2539 0.229057741311699 872 915875 SGTC_1979 st071809 45.3 µM -0.742698057951654 0.22979062736473 no 2540 0.228832252898502 863 4976333 SGTC_2610 ononetin 44.17 µM -0.743075566251001 0.229680677696137 no 2541 0.228717965809214 868 259632 SGTC_1487 3970-0795 2.82 µM -0.743153741783158 0.229657912677749 no 2542 0.228694302907747 845 3765103 SGTC_368 fentichlor 4.58 µM -0.744278509989959 0.229330515751399 no 2543 0.22835399975016 868 7329 A pesticide. SGTC_3252 9135871 49.47 µM -0.744294120223556 0.22932597377459 no 2544 0.22834927881406 860 17682838 SGTC_1514 1189-1591 158 µM -0.744422154189403 0.229288722724355 no 2545 0.228310560119956 871 767698 YMR146C TIF34 SGTC_2144 5628481 200 µM -0.745590586120919 0.228948928189015 no 2546 0.227957385681395 846 2818399 SGTC_3221 9128209 49.47 µM -0.745697198194668 0.228917938145917 no 2547 0.22792517604009 868 16460723 SGTC_1003 4049-0218 100 µM -0.746396303137427 0.228714780362894 no 2548 0.227714025900106 853 295161 SGTC_542 3381-0244 89.3 µM -0.749109883049259 0.227927182031722 no 2549 0.226895489366851 866 1112843 SGTC_731 3966-0296 387 µM -0.75020007867107 0.227611190240323 no 2550 0.226567105720425 837 660956 SGTC_2231 micatex 6.853 µM -0.751721169821326 0.227170716377348 no 2551 0.226109378364789 855 20737 An antifungal of unknown mechanism. SGTC_1596 piperlongumine 63 µM -0.751973258582497 0.227097763569165 no 2552 0.226033570230361 832 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.752061062866853 0.227072356695861 no 2553 0.226007169099157 854 4213774 SGTC_2625 euphol 100 µM -0.753127711841742 0.226763841279461 no 2554 0.225686586647017 847 6708538 A triterpene alcohol. SGTC_186 3455-3465 67.277 µM -0.753214551323186 0.226738734417124 no 2555 0.225660498281129 846 755278 SGTC_3238 9133470 49.47 µM -0.753703016080015 0.226597539663954 no 2556 0.225513785219675 829 3534688 SGTC_899 1083-0020 478 µM -0.754016855549327 0.226506847979854 no 2557 0.225419550312771 864 767123 SGTC_2657 nystatin 74.44 µM -0.754145807877013 0.226469589953474 no 2558 0.225380836946491 853 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_683 panaxydol 45 µM -0.755434604459695 0.22609740982986 no 2559 0.224994128326447 824 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_379 3970-0972 5.9 µM -0.75648039394317 0.225795659799642 no 2560 0.22468061152784 863 2898042 YBL034C STU1 SGTC_214 4373-3496 70 µM -0.758389421514263 0.225245420594386 no 2561 0.224108944416578 864 3779166 SGTC_2827 7993847 71.43 µM -0.759460525049597 0.224937029206871 no 2562 0.223788559663661 825 2985692 SGTC_1157 4092-0394 27.6 µM -0.760976232482669 0.224501037005642 no 2563 0.223335631743507 862 3659885 SGTC_2350 9023895 38.85 µM -0.761131745491271 0.224456330935388 no 2564 0.223289190438191 849 2997209 SGTC_3129 9127257 49.47 µM -0.761164677693961 0.224446864405428 no 2565 0.223279356503272 859 837894 SGTC_1691 st019933 84.6 µM -0.761649933203232 0.224307401498803 no 2566 0.223134482199529 878 6176082 SGTC_1144 3486-0183 12.5 µM -0.761918463806769 0.22423024669073 no 2567 0.223054334692873 888 6744069 SGTC_1615 st002656 86.5 µM -0.762337554418609 0.224109862763777 no 2568 0.22292928276594 850 1584458 SGTC_3081 9117243 49.47 µM -0.762816755450807 0.223972257092958 no 2569 0.222786343517347 851 45595589 SGTC_3124 9127567 49.47 µM -0.764690345791084 0.223434704536905 no 2570 0.222227978165837 858 17592030 SGTC_341 1486-1430 230 µM -0.764947680442798 0.223360929923333 no 2571 0.222151349993913 871 2054753 YPL210C SRP72 SGTC_2205 7238770 200 µM -0.766260654071813 0.222984732722976 no 2572 0.221760612346544 845 279867 SGTC_1244 0416-0015 52.5 µM -0.767644539688661 0.222588608537419 no 2573 0.221349196795428 860 96201 SGTC_187 1488-2104 32.728 µM -0.76786206723746 0.222526379839028 no 2574 0.221284567719444 845 2852859 SGTC_2692 st077426 47.7 µM -0.7679403323154 0.222503992761888 no 2575 0.221261317214715 860 25238571 SGTC_1661 st013063 9.66 µM -0.768928294471134 0.222221504826243 no 2576 0.220967939708675 878 721395 SGTC_1921 5740136 50 µM -0.769453428870392 0.222071436530961 no 2577 0.220812090582451 850 1774243 SGTC_1785 bathophenanthroline 24 µM -0.769538642448243 0.222047090399844 no 2578 0.220786806875915 839 72812 An iron chelator. SGTC_815 1582-0027 36.9 µM -0.769639559458954 0.222018259656106 no 2579 0.220756865950802 882 3128206 SGTC_2346 9031566 143.75 µM -0.770159701528881 0.221869695389488 no 2580 0.220602582619243 864 4771086 SGTC_148 3253-0744 288.01 µM -0.770211360840113 0.221854943429186 no 2581 0.220587262927461 862 6893655 SGTC_2281 7943571 200 µM -0.770621899101079 0.221737729028973 no 2582 0.220465538499529 856 1244024 SGTC_142 0335-0849 62.6745 µM -0.772065966967648 0.221325708728525 no 2583 0.220037678936726 838 3889043 YPR107C YTH1 SGTC_466 geldanamycin 89.2 µM -0.772667157006271 0.221154306828752 no 2584 0.219859694253683 827 5288382 HSP90 inhibitor. SGTC_1759 st043059 70 µM -0.77272506522505 0.221137800954075 no 2585 0.219842554660996 881 669426 SGTC_1506 4226-2149 212 µM -0.773176776215566 0.221009071664159 no 2586 0.219708884206747 871 991114 SGTC_2688 kanamycin b 96.69 µM -0.773624782002004 0.220881440661815 no 2587 0.219576356301438 843 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1407 3909-7909 12.3 µM -0.773699492573344 0.220860160700963 no 2588 0.219554260082287 839 4411780 SGTC_1753 st043925 64 µM -0.773734701490948 0.220850132481776 no 2589 0.219543847220157 871 670181 SGTC_608 k048-0125 159 µM -0.774089922585039 0.220748972840013 no 2590 0.219438808218327 849 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2537 larixol 68.93 µM -0.77489531876201 0.220519710936539 no 2591 0.219200759262825 857 6708759 SGTC_1421 4029-0249 71.4 µM -0.775774264689728 0.220269668326474 no 2592 0.218941140874808 872 2894095 SGTC_2499 avocadenofuran 51.48 µM -0.778279360111262 0.219557911157882 no 2593 0.218202170276174 882 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_3199 9111318 49.47 µM -0.779701287607584 0.219154496157064 no 2594 0.217783360386392 837 8548020 SGTC_280 3448-3607 3.04 µM -0.781142146531579 0.218746145166262 no 2595 0.21735944787432 840 626179 SGTC_1146 3579-1023 7 µM -0.782781953415892 0.218281943915537 no 2596 0.216877583419768 884 X1146 SGTC_3190 9110366 49.47 µM -0.783362433784543 0.218117755975999 no 2597 0.216707154824361 850 17123768 SGTC_3173 9105693 49.47 µM -0.786159256195686 0.217327677620944 no 2598 0.215887096267723 883 17096658 SGTC_1737 st035557 69.7 µM -0.786613113033264 0.217199622988271 no 2599 0.215754190327664 862 5716916 SGTC_301 4119-0100 24.5 µM -0.786824118452334 0.217140103153947 no 2600 0.215692416350651 879 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2315 7733312 200 µM -0.786934948749504 0.217108844220312 no 2601 0.215659973764617 870 726316 SGTC_965 1291-5240 308 µM -0.787027800942661 0.217082657890651 no 2602 0.215632795962746 879 2834598 SGTC_467 ro 31-8220 72.8 µM -0.789540288770744 0.216374775011913 no 2603 0.21489814595392 863 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3231 9132313 49.47 µM -0.790248328186058 0.21617552945553 no 2604 0.214691378507776 873 4905967 SGTC_464 bw-b 70c 158 µM -0.790538063909238 0.216094027130228 no 2605 0.214606800864194 876 5353454 SGTC_2021 4019055 173 µM -0.790750212291766 0.216034361322719 no 2606 0.214544884263033 876 44827708 YER133W GLC7 SGTC_1824 st053723 68.6 µM -0.792964500667962 0.215412172232913 no 2607 0.213899252890537 862 675225 SGTC_901 1112-0062 60.1 µM -0.793040765540819 0.215390761232471 no 2608 0.213877036122317 866 1908457 SGTC_934 2950-0684 338 µM -0.793077394585254 0.215380478241325 no 2609 0.213866366169919 873 1121253 SGTC_2312 7706453 155.7 µM -0.793931318011734 0.215140834261541 no 2610 0.213617708184676 875 976098 SGTC_2566 crystal violet carbinol 226 nM -0.794212563813292 0.215061939697415 no 2611 0.213535847783851 897 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1236 0330-0013 258 µM -0.794854571793984 0.214881907731031 no 2612 0.213349051169742 886 4617066 SGTC_3213 9129884 49.47 µM -0.795705691819539 0.214643371543314 no 2613 0.213101558894368 879 17190742 SGTC_39 0986-0283 58.349 µM -0.796710254756806 0.214362029326507 no 2614 0.212809663435482 835 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_808 0711-0032 135 µM -0.79826235317838 0.213927763906592 no 2615 0.212359129977679 844 4252555 SGTC_2412 st077135 33.4 µM -0.79883111278861 0.213768757584222 no 2616 0.212194173628782 891 13258915 SGTC_66 0109-0187 42.4 µM -0.800459394930747 0.213313924683855 no 2617 0.211722340209293 860 759417 SGTC_1137 ixabepilone 100 µM -0.800950797700825 0.213176770599018 no 2618 0.211580065290355 859 154225 A novel microtubule stabilizer. SGTC_41 0478-0632 82.643 µM -0.802837611851053 0.212650625153983 no 2619 0.211034299839102 870 3750424 SGTC_3307 9126885 69.2785 µM -0.803500531545853 0.212465947597201 no 2620 0.210842744826335 879 24824909 SGTC_1405 3909-7894 12 µM -0.803524954232562 0.212459145664027 no 2621 0.210835689678172 850 7104060 SGTC_839 0122-0028 230 µM -0.80352510370128 0.212459104036066 no 2622 0.21083564650055 874 759448 SGTC_2983 9022671 12.99 µM -0.804972237646931 0.212056291694387 no 2623 0.210417850296291 861 6405161 SGTC_1866 st057638 64 µM -0.805375061108883 0.211944244568197 no 2624 0.210301639288902 854 688802 SGTC_206 4546-0025 72.014 µM -0.805517102752285 0.211904743317287 no 2625 0.210260670519725 873 6620745 YIL048W NEO1 SGTC_998 3996-0085 177 µM -0.806431709407717 0.211650497783956 no 2626 0.20999698473866 873 715391 SGTC_3004 9076122 71.4286 µM -0.807959829368489 0.211226104310292 no 2627 0.209556853741756 886 44782551 SGTC_745 0469-0705 296 µM -0.810105635007581 0.210631007975859 no 2628 0.208939732954714 888 3486736 SGTC_1223 0764-0573 147 µM -0.811159368276609 0.21033913661067 no 2629 0.208637077950696 868 1609797 SGTC_937 3122-0005 46.7 µM -0.811537893670205 0.210234347657663 no 2630 0.208528420386408 856 759535 SGTC_1679 SEC14.276 6.7 µM -0.813234230729773 0.20976511945607 no 2631 0.208041888518674 868 1005053 YMR079W SEC14 SGTC_518 1021-0119 62.6 µM -0.813340392999094 0.209735774122168 no 2632 0.208011462074421 891 1097762 SGTC_1272 0839-0021 27 µM -0.813915170289733 0.20957693632013 no 2633 0.20784677469217 892 5027250 SGTC_2860 9025725 38.96 µM -0.813928496873978 0.20957325440213 no 2634 0.20784295722199 888 40546248 SGTC_143 4032-1194 15.74 µM -0.817454561016591 0.208600397831736 no 2635 0.206834353184847 882 1806963 SGTC_1402 3909-7673 35.9 µM -0.817797916897969 0.208505806895462 no 2636 0.206736293865387 864 5328014 SGTC_1668 st014914 51.6 µM -0.819583272084279 0.208014368128861 no 2637 0.206226856487276 877 2839556 SGTC_2636 apigenin dimethyl ether 100 µM -0.820134767275131 0.207862701319214 no 2638 0.20606964213503 878 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3186 9110464 49.47 µM -0.822963591023767 0.207085773076497 no 2639 0.205264349205177 869 17018021 SGTC_1281 0884-0031 11.8 µM -0.823998390344238 0.206801998162212 no 2640 0.204970236285227 884 1548255 SGTC_658 3253-0951 102 µM -0.825061222828574 0.206510775438987 no 2641 0.204668416672811 893 1184878 SGTC_2555 cholic acid 100 µM -0.825325185804682 0.206438485617242 no 2642 0.204593498356442 867 6708657 Influences liver metabolism. SGTC_3056 9094900 49.47 µM -0.825852378678299 0.206294151620185 no 2643 0.204443918634161 883 25236784 SGTC_2802 7925815 54.55 µM -0.826468531061195 0.20612553825692 no 2644 0.204269181068957 884 1262923 SGTC_1454 4239-0054 42.6 µM -0.827339448386225 0.205887346545395 no 2645 0.204022345252369 867 1340767 SGTC_1854 st056233 32.9 µM -0.827506474513536 0.205841684368302 no 2646 0.203975026941668 891 5393174 SGTC_2348 9022543 33.42 µM -0.828859497357038 0.205472011857343 no 2647 0.203591958211445 865 3162678 YDL140C RPO21 SGTC_2050 5263056 171 µM -0.828861617664649 0.205471432857059 no 2648 0.20359135824543 864 763468 YGL055W OLE1 SGTC_222 nsc-310342 10.666 µM -0.829163412952998 0.205389030378889 no 2649 0.203505972469842 881 432556 SGTC_2963 9082507 9 µM -0.833908724403448 0.20409594831862 no 2650 0.202166210279847 877 16459611 SGTC_1373 2887-0003 58.5 µM -0.834707869785177 0.203878661873296 no 2651 0.201941104781192 893 776948 SGTC_2179 6298986 200 µM -0.835831686328694 0.203573331192005 no 2652 0.201624798986799 854 738374 SGTC_3055 9094636 49.47 µM -0.836555821770768 0.203376734766939 no 2653 0.201421143472177 888 25236176 SGTC_3170 9103054 49.47 µM -0.837336495940677 0.203164915516454 no 2654 0.201201725186245 894 16432970 SGTC_3266 9136860 49.47 µM -0.841225595604106 0.202111655184935 no 2655 0.200110782005568 866 4871271 YPR165W RHO1 SGTC_1255 0566-0045 221 µM -0.84221024955152 0.201845506816719 no 2656 0.199835138831567 884 2788469 SGTC_2767 sibutramine 71.45 µM -0.843853993752125 0.2014016765852 no 2657 0.199375499636607 874 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2751 anetholtrithion 17.25 µM -0.844767671084354 0.201155226102365 no 2658 0.199120284070107 900 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2444 5485484 36.41 µM -0.844833286419 0.20113753433246 no 2659 0.199101963454334 912 6790631 SGTC_3146 9095609 49.47 µM -0.847167305508405 0.200508823194371 no 2660 0.198450937087438 892 17173999 SGTC_680 0417-1641 114 µM -0.848329186971685 0.200196289449531 no 2661 0.198127333643492 887 2835990 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.848780324113041 0.200075017310025 no 2662 0.198001770313348 888 641818 YHR062C RPP1 SGTC_1386 3228-0095 33.8 µM -0.849015743446086 0.200011750753 no 2663 0.197936266009361 886 870181 SGTC_1322 1348-1070 12 µM -0.849020561424128 0.200010456095899 no 2664 0.197934925566702 870 6758089 SGTC_543 3844-1095 191 µM -0.849062016348156 0.199999316794658 no 2665 0.197923392335009 897 4230703 SGTC_1140 3229-1848 2.98 µM -0.849981497900949 0.199752339946615 no 2666 0.197667686467034 886 2849525 SGTC_1224 0823-0416 294 µM -0.851437326880301 0.199361673215375 no 2667 0.197263232085446 884 3598164 SGTC_811 0416-0114 265 µM -0.851491685801129 0.199347095099607 no 2668 0.197248139942092 865 6612453 SGTC_841 0251-0215 91.2 µM -0.851582966234274 0.199322616721245 no 2669 0.197222798527225 888 3888614 SGTC_2716 st080858 38.6235 µM -0.853636050061767 0.198772526172499 no 2670 0.196653338734128 869 5296050 SGTC_562 3772-2733 112 µM -0.854229632825473 0.198613656014665 no 2671 0.196488883653221 880 2876874 YIL048W NEO1 SGTC_2917 7979103 53.79 µM -0.854929106713748 0.198426542827682 no 2672 0.196295197907942 887 2980565 SGTC_2458 5808907 16.39 µM -0.856496116456197 0.19800774515507 no 2673 0.195861710017177 882 2731747 SGTC_896 0964-0007 44.5 µM -0.858022636402788 0.197600282487619 no 2674 0.195439982040657 874 6756758 SGTC_2456 5770359 74.46 µM -0.86119515666704 0.196755088006661 no 2675 0.194565283574511 897 3118787 SGTC_3230 9131665 49.47 µM -0.8617425388192 0.196609481130236 no 2676 0.194414605686388 877 15943720 SGTC_1939 st074455 53.6 µM -0.861886769081594 0.196571125900092 no 2677 0.19437491524909 884 1644229 SGTC_1808 st050063 61.5 µM -0.862886004685536 0.196305523166836 no 2678 0.194100073106304 889 4011993 SGTC_538 2922-0838 53.3 µM -0.866949720693914 0.195227606806263 no 2679 0.192984779530586 907 777039 SGTC_2522 biochanin a 4.94 µM -0.869114986178517 0.194654733467056 no 2680 0.192392120292045 891 5280373 A possible chelator. SGTC_1739 st037196 92.5 µM -0.870683659833648 0.194240342535851 no 2681 0.191963451419761 889 612214 SGTC_1658 st012944 20 µM -0.870785573917421 0.194213438854063 no 2682 0.191935621763542 889 24207260 SGTC_2004 4023728 41.89 µM -0.871598252433925 0.193998985987361 no 2683 0.191713792192715 907 360084 YDR527W RBA50 SGTC_212 3807-4682 38.772 µM -0.872413232562274 0.193784070726788 no 2684 0.191491492112183 888 3125501 YBL034C STU1 SGTC_1136 pergolide 1.05886 µM -0.872449887883967 0.193774407905554 no 2685 0.19148149744495 891 47811 A dopamine receptor agonist. SGTC_1967 st070177 51.4 µM -0.874149723940724 0.193326631637628 no 2686 0.191018360748646 904 5729214 SGTC_2921 7974240 10.71 µM -0.875058389184901 0.193087527318048 no 2687 0.190771068188698 879 2979074 YDR527W RBA50 SGTC_2737 bleomycin 30.5 nM -0.875137744998424 0.193066654367064 no 2688 0.19074948089554 898 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1540 guanosine 70.6 µM -0.875800418654652 0.192892405180447 no 2689 0.190569271217306 873 6802 Guanosine is a purine nucleoside SGTC_2646 retinol 96.75 µM -0.87601493106069 0.192836020005556 no 2690 0.190510958400435 877 445354 A vitamin A analog and teratogen. SGTC_2600 tangeritin 87.95 µM -0.877759410454622 0.192377852784328 no 2691 0.190037147958152 906 68077 A bioactive flavone. SGTC_727 3032-0951 202 µM -0.878503557793218 0.192182613849987 no 2692 0.189835253906954 902 3652836 SGTC_742 0kpi-0133 140 µM -0.87900006276945 0.192052415286916 no 2693 0.18970062090151 898 2728852 SGTC_646 4092-0839 27.3 µM -0.879766418994023 0.19185155957904 no 2694 0.189492929958077 891 877796 SGTC_1624 st003710 6.25 µM -0.879839391844663 0.191832440698825 no 2695 0.189473160813777 909 24207033 SGTC_939 1165-0479 45.3 µM -0.882039428817596 0.191256579043682 no 2696 0.188877742775387 881 1377347 SGTC_2303 7774051 200 µM -0.882102210725688 0.19124016138923 no 2697 0.188860768415807 892 2953184 SGTC_2764 methyldopa 94.69 µM -0.882297884512267 0.19118899765857 no 2698 0.188807870077685 892 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_399 oxolinic acid 75 µM -0.882483666054351 0.191140428265996 no 2699 0.188757654454112 872 4628 A DNA gyrase inhibitor. SGTC_3114 9122766 49.47 µM -0.882724058018652 0.191077593145788 no 2700 0.188692690182364 861 17176985 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.882776990881303 0.191063758932661 no 2701 0.188678387292709 898 688788 SGTC_2570 licareol 100 µM -0.88409870201095 0.190718523677298 no 2702 0.188321466915818 902 443158 SGTC_1355 1499-0035 1.68 µM -0.884865963342941 0.190518288257067 no 2703 0.188114463679805 921 1548538 SGTC_3139 9095020 49.47 µM -0.88496742262584 0.190491819666892 no 2704 0.188087100993975 834 25236292 SGTC_2015 5119600 184 µM -0.885548174677721 0.190340357142296 no 2705 0.187930524497877 908 2828786 SGTC_2536 dehydroabietamide 32.04 µM -0.885821084693013 0.190269206642188 no 2706 0.187856973062609 897 3983547 SGTC_694 1315-0438 43.2 µM -0.887595291029516 0.189807050945082 no 2707 0.187379243787919 887 6793154 SGTC_3253 9135987 49.47 µM -0.887831105884593 0.189745676518884 no 2708 0.187315804009174 893 4182430 SGTC_622 1348-1566 26.3 µM -0.888581994722142 0.189550327525171 no 2709 0.187113885611191 901 7340407 SGTC_2466 5983409 37.09 µM -0.891879346221324 0.188693964069184 no 2710 0.186228803077838 910 2879657 SGTC_3287 9117173 37.0625 µM -0.892221295505777 0.188605292248525 no 2711 0.186137164987987 871 2789709 SGTC_1342 1486-1464 234 µM -0.893114869838217 0.188373698310219 no 2712 0.185897830326273 888 3253938 SGTC_2418 pentamidine 31.67 µM -0.894128992278495 0.188111073683861 no 2713 0.185626439401854 862 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1181 1222-0449 220 µM -0.894625785520309 0.187982502948251 no 2714 0.185493581528566 924 658318 SGTC_3215 9129942 49.47 µM -0.894675744775223 0.187969576431081 no 2715 0.185480224145876 917 17682944 SGTC_1418 3966-3099 2.4 µM -0.896334840253467 0.187540611853132 no 2716 0.185036978367864 880 740335 SGTC_2130 NSC 7 2.4545 µM -0.896958634089093 0.187379484514744 no 2717 0.184870495284952 898 21448 SGTC_1636 st007707 68.9 µM -0.898440504194792 0.186997057405624 no 2718 0.184475375352668 924 403051 SGTC_2309 7664088 163.95 µM -0.899072547846792 0.18683409252357 no 2719 0.184307009673024 893 704922 SGTC_343 4130-2827 29.8 µM -0.89938882488043 0.186752577286471 no 2720 0.184222794755728 895 1118244 SGTC_2697 mebhydrolin 72.4 µM -0.899645393004921 0.186686467220255 no 2721 0.184154496093919 912 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3136 9095672 49.47 µM -0.901306200420163 0.18625887647131 no 2722 0.183712768993006 856 17217380 SGTC_2441 5730946 39.09 µM -0.903643264883248 0.185658205651656 no 2723 0.183092296036142 871 1774275 SGTC_1779 st039427 55 µM -0.903674778119888 0.18565011436071 no 2724 0.183083938452714 898 1124498 SGTC_1400 3771-8998 51.5 µM -0.904238288882924 0.185505465128265 no 2725 0.182934530695953 885 670767 SGTC_1109 tnp00067 928.257 nM -0.904505535528834 0.185436889261765 no 2726 0.182863700232147 908 676295 SGTC_2586 curcumin 80 µM -0.905707088514873 0.185128763531634 no 2727 0.182545454797549 926 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_101 0490-5701 117.494 µM -0.9060562985826 0.185039271930671 no 2728 0.182453027321072 881 4661669 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.907437034353582 0.184685695885314 no 2729 0.182087866268006 910 390807 SGTC_2973 9094665 17.96 µM -0.908042707021876 0.184530729076828 no 2730 0.181927829223516 885 25237061 YIL048W NEO1 SGTC_2829 7992743 58.44 µM -0.908479587720209 0.184418999434691 no 2731 0.181812446750094 912 16462845 SGTC_3020 9089140 49.47 µM -0.908799127438593 0.184337305703816 no 2732 0.181728083632963 917 17217859 SGTC_2882 9058044 58.44 µM -0.910302235253797 0.183953322335391 no 2733 0.181331570029208 887 18076804 SGTC_1841 st054148 70 µM -0.913016379990614 0.183261230680691 no 2734 0.180616963389499 928 675442 SGTC_1450 4112-4260 37.6 µM -0.914182358724413 0.182964411942188 no 2735 0.180310516125533 893 1633175 SGTC_65 0798-0905 34.986 µM -0.91483345315059 0.182798795933463 no 2736 0.180139534894836 929 3602145 SGTC_1961 st076550 68.7 µM -0.914924916931867 0.182775538194567 no 2737 0.180115524122763 910 1579337 SGTC_662 k832-1615 104 µM -0.916997912066984 0.182248905018342 no 2738 0.179571867115209 903 5878478 SGTC_656 4090-1979 187 µM -0.917936277179464 0.182010830548033 no 2739 0.179326113948432 895 22330961 SGTC_184 1494-0393 24.714 µM -0.918435456546114 0.181884262036952 no 2740 0.179195467565621 910 3090647 SGTC_1755 st041960 45.185 µM -0.91887268254349 0.181773447234057 no 2741 0.179081084958276 911 2257073 SGTC_1143 3454-2408 5.08 µM -0.919277194397047 0.181670961444048 no 2742 0.178975301608263 868 X1143 SGTC_559 1550-0661 158 µM -0.920204881146557 0.181436062357467 no 2743 0.17873285202265 907 5830875 SGTC_2906 7926292 26.41 µM -0.920477300740966 0.181367119263187 no 2744 0.178661694851499 923 2966319 SGTC_873 0591-4978 488 µM -0.927875729530861 0.179501023466841 no 2745 0.1767360177047 905 3305145 SGTC_1129 3453-1384 223 µM -0.931507353128016 0.178589456017538 no 2746 0.175795591378991 934 1084452 SGTC_265 mycophenolic acid 32.932 µM -0.933740183025283 0.178030447194031 no 2747 0.175218965904057 922 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1022 4477-0945 21.3 µM -0.934000658007967 0.177965306898857 no 2748 0.175151776785641 891 4648966 SGTC_2524 avocatin b 10.57 µM -0.934178182088394 0.177920919805403 no 2749 0.1751059940894 884 6710748 SGTC_3007 9078383 71.4286 µM -0.939682439760321 0.176548132549332 no 2750 0.173690237580143 912 6496995 SGTC_936 3005-4620 401 µM -0.940271277411364 0.176401671414281 no 2751 0.173539214340705 902 777207 SGTC_618 k072-0232 33.2 µM -0.940847494827037 0.176258423736967 no 2752 0.173391508824968 899 5872756 YGL099W LSG1 SGTC_1686 st019653 115.5 µM -0.949301264194621 0.174165284246684 no 2753 0.171233705385358 941 97252 SGTC_3347 9188721 44.724 µM -0.951285856829569 0.173676201435653 no 2754 0.170729642276771 915 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1579 chlormadinone acetate 49.4 µM -0.952623286141722 0.173347098819149 no 2755 0.170390487241721 936 45114258 A steroidal progestin. SGTC_1722 st034304 3.6505 µM -0.953540144520221 0.173121716062749 no 2756 0.170158233124322 939 4036148 YLR033W RSC58 SGTC_1126 isoteolin 1.0172 µM -0.953606969798236 0.173105296327834 no 2757 0.170141313204345 900 133323 SGTC_1347 1493-0251 600 nM -0.95392024802262 0.173028333511986 no 2758 0.170062006660362 865 3986378 SGTC_2057 5236571 38.335 µM -0.954474086171746 0.172892325870459 no 2759 0.169921860224939 927 54684039 YBR257W POP4 SGTC_2999 9069765 71.4286 µM -0.954954880133264 0.172774311158145 no 2760 0.169800257373611 895 2097066 SGTC_2252 omeprazole 400 µM -0.956238312980734 0.172459533866184 no 2761 0.169475923742303 902 4594 A proton pump inhibitor. SGTC_743 1275-0778 158 µM -0.957629823009727 0.172118662896156 no 2762 0.169124727612064 919 2849257 YMR203W TOM40 SGTC_684 1140-0066 328 µM -0.959179977343191 0.171739436364282 no 2763 0.168734042749376 909 6813534 SGTC_316 k060-0003 58.6 µM -0.959181329136701 0.171739105897406 no 2764 0.168733702310628 917 6152314 SGTC_3328 9140624 29.0385 µM -0.960336310370651 0.171456901266796 no 2765 0.168442990527167 924 4904392 SGTC_1896 st058441 89 µM -0.962065106269236 0.171035046637163 no 2766 0.168008450314695 904 688759 SGTC_3246 9135460 32.98 µM -0.962321822107722 0.170972460412445 no 2767 0.167943985270806 908 41446951 SGTC_1168 k815-0004 80.5 µM -0.96397176209398 0.170570561840967 no 2768 0.167530041650677 931 642433 SGTC_3195 9113082 49.47 µM -0.965273007460519 0.170254026600985 no 2769 0.167204043943406 906 17018038 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.96664333412496 0.169921094055286 no 2770 0.166861181852393 920 6728940 SGTC_2267 7931562 200 µM -0.969399628196235 0.169252693966897 no 2771 0.16617291888736 925 934880 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.969892622892511 0.169133321159811 no 2772 0.166050008801631 907 5024745 SGTC_3047 9092122 49.47 µM -0.970124954899348 0.169077083472382 no 2773 0.165992105734619 930 17173831 SGTC_1448 4255-0083 152 µM -0.970232064113269 0.169051160936566 no 2774 0.165965415778979 947 5399660 SGTC_351 caspofungin 25 nM -0.972161839601711 0.168584554645075 no 2775 0.165485020796235 892 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1675 st018485 24.5 µM -0.972728903255463 0.168447600133578 no 2776 0.165344028108726 930 3323024 SGTC_3040 9091894 49.47 µM -0.974314246620122 0.168065095268263 no 2777 0.164950266516771 874 25236966 SGTC_2174 5790901 200 µM -0.980943504085263 0.166471677444189 no 2778 0.163310301224214 932 786020 SGTC_1719 st032227 49.2 µM -0.981937882858167 0.16623351106009 no 2779 0.163065225622538 914 3125804 SGTC_2788 5282734 71.43 µM -0.98419194191087 0.165694450503795 no 2780 0.162510573538245 933 743706 SGTC_2659 sanguinarine 24.21 µM -0.985153409623785 0.165464858776352 no 2781 0.162274360923125 905 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2129 girgensonine 121.053 µM -0.985743787085807 0.165323982819698 no 2782 0.162129428281372 927 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2876 9059903 25.97 µM -0.986820051067333 0.165067364318645 no 2783 0.161865431608541 889 6916095 SGTC_854 0422-0053 192 µM -0.98957187071155 0.164412408757412 no 2784 0.161191712351554 926 3596728 SGTC_85 0868-0259 160.055 µM -0.989682527064406 0.164386106922477 no 2785 0.161164659025716 903 83173 SGTC_2206 7254556 146.969 µM -0.990367298590062 0.164223404706936 no 2786 0.160997311599844 912 4398905 SGTC_16 erodoxin 22.806 µM -0.990701575644008 0.164144018179666 no 2787 0.160915660737314 928 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1783 st039459 87.517 µM -0.991628543120799 0.163924005489904 no 2788 0.160689380128891 935 729761 SGTC_685 1278-0033 54.9 µM -0.991988358699262 0.163838656020719 no 2789 0.160601602112789 927 3590572 SGTC_1606 st000094 49.2 µM -0.993322672567636 0.16352240409474 no 2790 0.160276365986228 912 1242210 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.994169205196342 0.163321969138944 no 2791 0.160070248831963 930 5357218 A potent inhibitor of glutathione S-transferases. SGTC_84 0443-0269 128.823 µM -0.995067465101112 0.163109461240186 no 2792 0.159851726524538 889 6150058 SGTC_2123 5259487 200 µM -0.996177076444286 0.162847200616271 no 2793 0.159582057679863 923 2173474 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.996839558975793 0.162690751294408 no 2794 0.159421196582548 907 77254 SGTC_1372 2752-0194 270 µM -1.00067882706563 0.16178601033133 no 2795 0.158491053405363 916 823334 SGTC_1019 4262-0212 3.4 µM -1.00349045807518 0.161125520474617 no 2796 0.157812139259781 930 4677213 SGTC_3027 9089541 49.47 µM -1.00533986675543 0.160692030180137 no 2797 0.157366612285462 941 9943819 SGTC_2859 9028643 45.46 µM -1.00731077040638 0.160230901304894 no 2798 0.156892727810603 887 17151580 SGTC_2370 9071495 200 µM -1.0087037223666 0.159905516977861 no 2799 0.15655837302875 959 21791103 SGTC_1227 3909-8010 46.6 µM -1.00889440076763 0.159861009423019 no 2800 0.15651264040375 929 15982272 SGTC_2909 7941780 10.49 µM -1.01072189732564 0.159434851951199 no 2801 0.156074776767656 916 1243215 SGTC_2183 6420625 130.508 µM -1.01140993997581 0.159274598846736 no 2802 0.155910132836541 932 2897619 SGTC_1742 st038235 28.8875 µM -1.01167988850277 0.159211753529413 no 2803 0.155845567272127 924 564103 YBR002C RER2 SGTC_179 1273-0063 6.77 µM -1.01265015747608 0.158986004352923 no 2804 0.155613646508788 956 3108139 SGTC_2531 methyl deoxycholate 70.07 µM -1.01337722709875 0.158816977080906 no 2805 0.155440006309693 961 16667744 Haematoxylin. SGTC_2955 9076254 12.21 µM -1.01480255205947 0.15848596312506 no 2806 0.155099978493553 921 16459619 SGTC_121 0557-0495 61.343 µM -1.01523405538194 0.158385841154948 no 2807 0.154997135283197 953 3104427 SGTC_611 3453-1652 23.7 µM -1.01675526782356 0.158033204401298 no 2808 0.154634933362412 933 1560575 SGTC_337 1315-0038 354 µM -1.0212791225088 0.156987564092893 no 2809 0.153561107424045 925 1626437 SGTC_275 trichlorophene 5.69 µM -1.02168148468896 0.156894783310022 no 2810 0.153465838555393 906 62616 SGTC_1878 temozolomide 1 mM -1.02507876654332 0.156112841914512 no 2811 0.152663011767006 906 5394 DNA alkylating agent. SGTC_2125 5246583 200 µM -1.02890888575009 0.155234360563034 no 2812 0.15176124623228 936 835267 SGTC_1377 2944-0135 198 µM -1.02968649898026 0.155056405398828 no 2813 0.151578597672945 916 1894137 SGTC_2249 haloperidol 116.36 µM -1.03248958540134 0.154416043290711 no 2814 0.150921411994322 922 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_304 1310-0298 97 µM -1.03298577589594 0.154302871502279 no 2815 0.150805277631191 937 1550234 SGTC_2316 5844804 197.44 µM -1.03324866380188 0.15424293391199 no 2816 0.150743772315801 923 776813 SGTC_563 tetrahydrosecaminediol 614 µM -1.03382016440061 0.154112686756188 no 2817 0.150610121532147 947 334274 A psychoactive constituent of the cannabis plant. SGTC_3329 9141233 27.5565 µM -1.03385739844203 0.154104203502048 no 2818 0.150601416740932 932 4909101 YNL103W MET4 SGTC_3017 9080681 49.47 µM -1.03429686134327 0.154004101382897 no 2819 0.150498701858889 954 16451914 SGTC_2324 6149169 200 µM -1.03512217745487 0.153816224807303 no 2820 0.150305928334223 934 2888231 SGTC_1726 st035556 14.5795 µM -1.03967688436752 0.152782112217588 no 2821 0.149245021736086 925 5919439 SGTC_3049 9092223 49.47 µM -1.04291291940776 0.152050202528006 no 2822 0.148494312750886 942 8623917 SGTC_218 alverine citrate 93.75 µM -1.04484615665634 0.15161406587441 no 2823 0.148047039170782 926 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_728 3030-5151 22.5 µM -1.04880588377076 0.150723353176527 no 2824 0.147133734468381 947 3125388 SGTC_846 0335-0850 148 µM -1.05038066415972 0.15037008778026 no 2825 0.146771565972098 920 6819598 SGTC_1872 amphotericin b 148 nM -1.05116660368825 0.1501939870459 no 2826 0.146591039268653 930 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1397 3532-0190 20.1 µM -1.05119197908696 0.15018830362488 no 2827 0.146585213140438 907 5322280 SGTC_1972 st070201 17.4 µM -1.05183070345567 0.15004529340306 no 2828 0.146438614805485 940 2829099 SGTC_807 1315-0151 48 µM -1.05397374232822 0.149566131075803 no 2829 0.145947469473063 960 4011080 SGTC_2207 7258803 200 µM -1.05403113566641 0.149553312547747 no 2830 0.145934331205849 943 3666799 SGTC_1834 st055981 52.8 µM -1.05745459313564 0.148790025746434 no 2831 0.145152083617021 947 471719 YDL150W RPC53 SGTC_3181 9108277 49.47 µM -1.05907207841666 0.148430301890952 no 2832 0.144783477455007 961 17097298 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.05943092092509 0.14835057529545 no 2833 0.1447017869159 931 756377 SGTC_1983 st071813 46.9 µM -1.05976875298467 0.148275542923146 no 2834 0.144624907784462 947 11838595 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.06090419668473 0.148023547389111 no 2835 0.14436672093843 965 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3064 1327-0027 10 µM -1.06395313812548 0.14734829730999 no 2836 0.14367496450368 907 16000455 YPR107C YTH1 SGTC_1616 st002734 56.1 µM -1.06534159484139 0.147041480490541 no 2837 0.143360688182395 943 4026101 SGTC_1220 1838-0075 193 µM -1.06588323158279 0.146921907536768 no 2838 0.143238214996083 917 5529645 SGTC_70 0141-0289 43.283 µM -1.06918406486914 0.146194618124619 no 2839 0.142493368827652 915 352408 SGTC_2662 daunorubicin 22.37 µM -1.07042165915246 0.145922556987378 no 2840 0.142214777181913 906 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2093 5331342 194.4 µM -1.0711981346804 0.145752037677656 no 2841 0.142040175080478 936 33839 SGTC_772 k072-0172 35.3 µM -1.0717264315319 0.145636096692479 no 2842 0.141921462640147 914 5861980 SGTC_141 0443-0274 32.331 µM -1.07400629061427 0.145136466031673 no 2843 0.141409931072556 858 1627241 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.07402216953192 0.145132990220037 no 2844 0.141406372710014 960 803109 SGTC_520 3584-0023 682 µM -1.07947467819472 0.143942776368761 no 2845 0.140188088007407 940 1340790 SGTC_3154 9100113 49.47 µM -1.08062868433192 0.143691717953528 no 2846 0.139931158842446 953 25237525 SGTC_605 1315-0399 119 µM -1.08156804395038 0.143487574991356 no 2847 0.139722255217142 947 24020461 SGTC_1087 pterostilbene 9.05 µM -1.08195291208852 0.143403991472559 no 2848 0.139636725885331 958 5281727 Similar to reservatol, lowers cholesterol. SGTC_3061 glucosamine 200 µM -1.08712864314426 0.142283148683784 no 2849 0.1384899804083 915 91431 and experimental redox chemotherapeutic SGTC_1801 st050089 28.441 µM -1.08792631926973 0.142110934627822 no 2850 0.13831381803986 944 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_365 0121-0052 13.6 µM -1.09164347688283 0.141310280973704 no 2851 0.137494919178776 920 3101739 SGTC_3343 9148379 18.9835 µM -1.09558937492906 0.140463709785171 no 2852 0.136629256774249 922 1955036 SGTC_2192 5915882 198.485 µM -1.09838468463875 0.139866078907498 no 2853 0.136018273582623 940 2876149 SGTC_271 rotenone 740 µM -1.1012634924612 0.139252405257662 no 2854 0.135390997627771 961 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_3216 9129716 49.47 µM -1.10221591351248 0.139049782218142 no 2855 0.135183907622656 938 8056934 SGTC_602 3130-1533 38.1 µM -1.10231644098859 0.139028407192481 no 2856 0.135162062073772 975 720941 SGTC_93 0109-0045 59.227 µM -1.1032049539786 0.138839581093711 no 2857 0.134969085237267 961 88733 SGTC_1070 indatraline 8.81 µM -1.10491614216674 0.138476412953605 no 2858 0.134597963589037 952 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_427 1354-0053 47.3 µM -1.10494035128304 0.138471279663333 no 2859 0.134592718157466 975 6813657 SGTC_1997 st073024 93.8 µM -1.10574602295589 0.138300519364899 no 2860 0.134418231897715 949 686268 SGTC_2571 chrysanthemic acid 100 µM -1.10634573168391 0.138173505679141 no 2861 0.134288452403385 985 2743 An insecticide. SGTC_1758 st042942 75.2445 µM -1.107549778466 0.137918738056215 no 2862 0.134028151496798 936 669317 SGTC_2641 levomentholum 100 µM -1.10812044164903 0.137798101836808 no 2863 0.133904901927565 949 16666 SGTC_581 0958-0271 211 µM -1.10858576246239 0.137699787932726 no 2864 0.133804461453081 953 4591145 SGTC_3128 9127691 49.47 µM -1.11078159100025 0.137236494934919 no 2865 0.133331186127718 954 41316314 SGTC_629 3448-6466 76.7 µM -1.11134965016932 0.137116814932204 no 2866 0.133208937897987 957 573744 SGTC_1851 st056236 18.9 µM -1.11514004977229 0.136320070244702 no 2867 0.132395205721198 921 5393171 SGTC_1799 st045822 46.1415 µM -1.11552029675894 0.136240317235818 no 2868 0.132313762852488 916 3674992 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.11842044244971 0.135633091078036 no 2869 0.131693733758206 945 2724278 An inhibitor of dopamine biosynthesis. SGTC_151 3013-0144 2.285 µM -1.11922564054894 0.135464829807511 no 2870 0.131521944701846 951 906558 YHR107C CDC12 SGTC_2147 5545932 89.7195 µM -1.11962784726834 0.135380834750697 no 2871 0.131436191833565 979 797404 SGTC_2226 7298446 200 µM -1.11997081172154 0.135309239786123 no 2872 0.131363100265973 960 3283010 SGTC_824 1304-0008 100 µM -1.12250289527702 0.134781462128804 no 2873 0.130824338609574 957 768245 SGTC_519 k048-0011 62.8 µM -1.12367304611167 0.1345380382692 no 2874 0.130575877551644 937 6836379 SGTC_1503 4585-0012 61.3 µM -1.12975304715766 0.133278088275578 no 2875 0.129290148895582 970 2922052 SGTC_1043 0916-0009 19.3 µM -1.13144610434555 0.132928688227029 no 2876 0.128933687851624 963 3101130 SGTC_2532 xanthone 78.9 µM -1.132134835912 0.132786733745544 no 2877 0.128788875578638 971 7020 An insecticide. SGTC_3106 9121286 49.47 µM -1.13237709347585 0.132736826860451 no 2878 0.128737965487592 928 15943471 SGTC_635 k038-0028 24.7 µM -1.13278347567398 0.132653138077488 no 2879 0.128652596191149 977 4035102 SGTC_1142 3253-1408 9.78 µM -1.13325500574462 0.132556078554965 no 2880 0.12855359042958 974 256655 SGTC_670 4204-0025 119 µM -1.13337612954212 0.132531154391161 no 2881 0.128528166965726 960 719039 SGTC_1867 st057372 64 µM -1.13577535491338 0.132038120842985 no 2882 0.128025296969176 953 688837 SGTC_1216 1165-0504 9.65 µM -1.13671377594801 0.131845622714506 no 2883 0.127828979255743 978 6304004 SGTC_3318 9139014 38.6185 µM -1.13702002417703 0.131782843994587 no 2884 0.127764957415897 956 16643984 SGTC_2879 9041815 71.43 µM -1.13774954230618 0.13163338102887 no 2885 0.127612539892454 954 4942971 SGTC_1703 st026983 48.3 µM -1.13867761839415 0.131443406840655 no 2886 0.127418820608559 946 1104023 SGTC_2407 paclitaxel 400 µM -1.14006294749584 0.131160186715233 no 2887 0.127130038579525 991 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_651 3253-0966 34.4 µM -1.14430323057579 0.130295913557232 no 2888 0.126248951995225 961 781462 SGTC_2670 beta-carotene 100 µM -1.14450547281061 0.130254790326572 no 2889 0.126207034764853 920 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_530 4358-1714 28 µM -1.14556002305356 0.13004050725118 no 2890 0.125988623214369 939 1564641 SGTC_3336 9143619 71.43 µM -1.14911367430048 0.129320207527896 no 2891 0.125254555274641 981 45595730 SGTC_1846 st056244 14.8 µM -1.15035250358872 0.129069756899901 no 2892 0.124999357076792 959 5393182 SGTC_2239 6685329 187.64 µM -1.1560669812853 0.127918831796114 no 2893 0.123826880244355 939 805680 SGTC_3222 9128301 49.47 µM -1.16316473901578 0.126499262123103 no 2894 0.122381334915808 949 4911358 SGTC_1158 4092-0494 91.8 µM -1.16348026440373 0.126436412022376 no 2895 0.122317350407623 972 1148199 SGTC_1167 k781-0610 148 µM -1.16377301747296 0.12637811744315 no 2896 0.122258004837709 955 4525169 SGTC_1276 0871-0068 94.2 µM -1.16588276268104 0.125958567307208 no 2897 0.121830924563685 963 3414906 SGTC_3095 9117207 49.47 µM -1.1670022311425 0.125736341352106 no 2898 0.121604734259246 968 17015229 SGTC_1620 st003704 16.5 µM -1.16717838080481 0.125701398759377 no 2899 0.121569169844085 968 2834414 SGTC_3284 9108171 64.8615 µM -1.16724683804707 0.125687820808248 no 2900 0.121555350378073 948 8687505 SGTC_199 4063-0024 41.6 µM -1.16921018891737 0.125298841166179 no 2901 0.121159478540766 976 306215 SGTC_2052 5265182 7.135 µM -1.17031786060352 0.125079760136883 no 2902 0.120936538455356 955 1239884 SGTC_3125 9127534 49.47 µM -1.17182028634017 0.1247830303643 no 2903 0.120634608107971 954 1639235 SGTC_1138 3761-0006 1.03 µM -1.17208040279903 0.124731707240598 no 2904 0.120582388549284 969 12061087 SGTC_903 1134-0042 114 µM -1.1723435983237 0.124679791609051 no 2905 0.120529567056062 952 701009 SGTC_116 0155-0182 31.788 µM -1.1725525413631 0.124638588100237 no 2906 0.12048764525911 864 771486 SGTC_619 1652-1634 108 µM -1.1751429498884 0.124128550628181 no 2907 0.119968764979446 979 5400454 SGTC_1444 4112-3581 28 µM -1.17602689011361 0.123954842182759 no 2908 0.119792065405354 962 2877249 SGTC_1552 6-methylflavone 10.6 µM -1.17664947334577 0.123832596738313 no 2909 0.119667721265889 971 689013 SGTC_2354 9060492 162 µM -1.17745898186879 0.123673774382331 no 2910 0.119506180028207 986 6471895 SGTC_3269 9137823 49.47 µM -1.17889287264832 0.123392800897764 no 2911 0.119220418085624 921 17682936 SGTC_249 wiskostatin 11.211 µM -1.17930727166313 0.123311682023955 no 2912 0.11913792188056 935 2775510 A n-wasp and actin depolymerizer. SGTC_400 oxethazaine 37.5 µM -1.18071611861619 0.123036178804268 no 2913 0.118857758038024 972 4621 A local anesthetic. SGTC_69 0096-0274 206.684 µM -1.18140325578346 0.122901964234421 no 2914 0.118721282632956 978 6741392 SGTC_1420 4'-methoxyflavone 42 µM -1.18278024071422 0.122633314718552 no 2915 0.118448126758025 963 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_456 gingerol 170 µM -1.18358217293576 0.122477047838906 no 2916 0.11828925033507 973 442793 A herb. SGTC_307 1501-1223 22.3 µM -1.18371242756703 0.122451679233867 no 2917 0.118263458905792 980 2830329 SGTC_327 1273-0057 3.96 µM -1.18455120420483 0.122288406049087 no 2918 0.118097469851764 950 3108138 SGTC_1403 3909-7815 62.9 µM -1.18564365223682 0.122075983337812 no 2919 0.117881527844319 951 6615483 SGTC_1712 st032288 53.4 µM -1.18651749583392 0.121906254124393 no 2920 0.117708998156556 970 2883011 SGTC_2669 eugenol 100 µM -1.1887850137739 0.121466600802799 no 2921 0.11726213835741 952 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_922 1866-0035 480 µM -1.18878718872447 0.12146617963333 no 2922 0.117261710317481 952 3156169 SGTC_1976 st070609 63.5 µM -1.19028055230225 0.121177238756752 no 2923 0.116968070947902 957 682556 SGTC_2976 9009005 19.48 µM -1.19339452611875 0.120576292796422 no 2924 0.116357448880122 948 2993148 SGTC_1973 st070275 50.2 µM -1.19444739497464 0.120373581843088 no 2925 0.116151503329291 981 17118334 SGTC_2302 7771753 200 µM -1.19733454095712 0.119818945859123 no 2926 0.115588093243797 964 2203047 SGTC_1891 st059073 26.2 µM -1.19907582634424 0.119485308115701 no 2927 0.115249231381499 975 688754 SGTC_1040 k898-0338 155 µM -1.201031786353 0.119111320029474 no 2928 0.114869435720887 976 20969351 SGTC_767 0929-0023 86 µM -1.20396660707856 0.118551721012573 no 2929 0.114301242739704 976 1204563 SGTC_833 3852-0053 558 µM -1.20487349481313 0.1183791759127 no 2930 0.114126071095287 1010 3123681 SGTC_958 1222-0007 33 µM -1.20589035422126 0.118185918731265 no 2931 0.113929885163904 967 7312461 SGTC_1171 0368-0077 21.4 µM -1.20845508618077 0.117699475026904 no 2932 0.113436130946947 977 3239779 SGTC_692 k241-0027 77.8 µM -1.2117271000355 0.117080943077056 no 2933 0.11280843092571 961 3600480 SGTC_416 estradiol valerate 100 µM -1.21175601098754 0.117075488119415 no 2934 0.112802895750865 986 13791 A steroid. SGTC_3105 9121040 49.47 µM -1.21694732542634 0.116098901517663 no 2935 0.11181212891936 922 41448907 SGTC_2863 9028737 58.44 µM -1.21826932672492 0.115851133874277 no 2936 0.11156082111833 977 6460917 SGTC_2886 9058944 51.95 µM -1.22034617343467 0.115462652826238 no 2937 0.111166836496743 958 4949929 SGTC_2099 5377090 177.372 µM -1.22083025230015 0.11537223745198 no 2938 0.111075148495977 976 2243829 SGTC_334 1502-1024 68.5 µM -1.22190252703742 0.11517213912401 no 2939 0.110872244862375 983 3296216 SGTC_326 k292-0812 17.5 µM -1.22306534507905 0.11495542341677 no 2940 0.110652508232576 954 3579357 SGTC_1494 4358-1428 177 µM -1.22405121609692 0.114771912842064 no 2941 0.110466453742827 966 1564571 SGTC_297 0986-0032 24 µM -1.22710541458633 0.114204725946374 no 2942 0.109891486520036 977 2847425 SGTC_2263 7948595 193.29 µM -1.22854729147498 0.113937653693141 no 2943 0.109620793970591 960 2971371 SGTC_1746 st038117 42 µM -1.22881684725054 0.113887774524971 no 2944 0.109570241744449 973 2898218 SGTC_3337 9144342 33.5465 µM -1.22923369575796 0.113810670639449 no 2945 0.109492099346601 975 17682949 SGTC_2453 5731132 22.18 µM -1.22937631816888 0.113784298515312 no 2946 0.109465372548877 997 1362040 SGTC_3001 9076041 71.4286 µM -1.23035273745648 0.113603867070563 no 2947 0.109282521807185 976 16004211 SGTC_192 3455-0609 60.9 µM -1.23490827324006 0.112764750644103 no 2948 0.108432322022478 985 3769639 SGTC_2014 4013930 200 µM -1.23583403463633 0.112594770519198 no 2949 0.108260130549677 989 64556 SGTC_935 2996-0153 430 µM -1.23652026085462 0.112468889883156 no 2950 0.108132619650524 986 23738523 SGTC_2738 aclarubicin 5.55 µM -1.23710909364858 0.112360955171174 no 2951 0.108023292095969 985 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_483 fpl-64176 144 µM -1.23788821501354 0.112218253809998 no 2952 0.107878756350553 992 3423 SGTC_3319 9138450 16.7555 µM -1.23881143354125 0.112049327812027 no 2953 0.107707669332143 950 2029690 SGTC_2491 paeonol 100 µM -1.23909743544338 0.111997033487983 no 2954 0.107654708327312 1012 11092 Increases levels of cortical cytochrome oxidase. SGTC_412 gemfibrozil 100 µM -1.24398033259535 0.111106905892288 no 2955 0.106753400720121 977 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_951 1171-0579 82.7 µM -1.24406181698365 0.111092094798505 no 2956 0.106738406291647 961 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_139 0099-0334 718.624 µM -1.24691332756099 0.110574677252467 no 2957 0.106214639690625 988 97690 SGTC_225 nsc-122657 1.016 µM -1.25468772673762 0.109172763474326 no 2958 0.104796071441321 988 275685 SGTC_2742 clothiapine 36.27 µM -1.25559293705936 0.109010365834193 no 2959 0.104631796716696 978 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_653 0203-0016 55.2 µM -1.25769109385256 0.108634617591251 no 2960 0.104251747213316 1001 295302 SGTC_2741 miltefosine 3.04 µM -1.26004363195808 0.108214422328764 no 2961 0.103826811390596 957 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1190 1486-1332 13 µM -1.26120711431157 0.108007041471381 no 2962 0.10361711805637 977 4150046 SGTC_396 dithiazanine 1.25 µM -1.2653536052765 0.10727029213458 no 2963 0.102872299258187 974 10578 An antihelmenthic. SGTC_2504 purpurogallin 52.29 µM -1.26538678162206 0.107264412002485 no 2964 0.102866355641948 978 5281571 An antioxidant. SGTC_1569 carminic acid 40.6 µM -1.26715344893152 0.106951625802061 no 2965 0.102550213566762 987 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2928 9011484 9.79 µM -1.26768020133994 0.106858492421229 no 2966 0.102456088970721 951 2994751 SGTC_2880 9042983 58.44 µM -1.26945314383062 0.106545454167191 no 2967 0.10213974608251 995 6464714 SGTC_2191 5911152 200 µM -1.26961635650185 0.10651666995615 no 2968 0.102110660101426 980 2875902 SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.26988798367588 0.106468778194183 no 2969 0.102062267031299 979 5282309 SGTC_1618 st003135 44.5 µM -1.27285990709146 0.105945800856054 no 2970 0.101533879235429 1005 1270615 SGTC_2953 9074162 66.49 µM -1.27618647557268 0.105362620511115 no 2971 0.100944804160259 970 16451992 SGTC_2745 rifampicin 24.3 µM -1.2777844731821 0.105083302899935 no 2972 0.100662715276091 966 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1907 st060210 83.7 µM -1.28487057226142 0.103851164514712 no 2973 0.0994187579523289 996 688793 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.28511267092528 0.103809254056467 no 2974 0.0993764571911965 996 1273210 SGTC_2736 butenafine 14.65 µM -1.28679562821974 0.103518251089322 no 2975 0.0990827655651838 983 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_164 4100-3994 89.624 µM -1.28943748610867 0.103062637875714 no 2976 0.0986230181595283 1008 4615967 SGTC_1186 1319-0216 26 µM -1.29090739363226 0.102809770022954 no 2977 0.0983678956567143 985 4565136 SGTC_1016 4226-1401 38 µM -1.2912088465049 0.102757966911471 no 2978 0.0983156341741388 988 2901613 SGTC_2382 9035899 200 µM -1.29220330014659 0.102587209722375 no 2979 0.0981433745662759 1006 6462679 SGTC_1101 ebselen 5.29 µM -1.29530213949211 0.102056432433739 no 2980 0.0976080107200919 992 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3351 9150312 21.596 µM -1.29596283675254 0.101943525373771 no 2981 0.0974941443647013 986 4904905 SGTC_473 2-arachidonoylglycerol 10 µM -1.30008326412124 0.101241433187755 no 2982 0.0967862165026288 957 5282280 An endocannabinoid. SGTC_2771 fluoxetine 41.05 µM -1.30417131680126 0.100548345840036 no 2983 0.0960875886301871 980 3386 A selective serotonin reuptake inhibitor. SGTC_150 3970-0969 77.2 µM -1.30548317788573 0.100326668580063 no 2984 0.0958641858061717 991 6615640 SGTC_2518 prenyletin 46.28 µM -1.30740287702644 0.100002922510007 no 2985 0.0955379603784312 981 3873459 A coumarin with calcium channel inhibitory activity. SGTC_966 1300-0360 30.2 µM -1.30785557909062 0.0999266882311341 no 2986 0.0954611493224445 945 70588 SGTC_2024 5144227 134 µM -1.30860587218246 0.099800433594616 no 2987 0.0953339453873072 988 3475211 SGTC_393 acivicin 6.25 µM -1.3092143688529 0.0996981251804909 no 2988 0.0952308731509089 961 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1401 3807-4679 7.6 µM -1.30971785246567 0.0996135308832835 no 2989 0.0951456509569954 981 3291456 SGTC_2479 5617353 43.85 µM -1.31162245588624 0.0992939977645329 no 2990 0.0948237761935528 990 2731746 SGTC_2967 9089538 49.85 µM -1.31361185713228 0.0989610390806659 no 2991 0.0944884282342363 992 728216 SGTC_3042 9091578 49.47 µM -1.3139267956997 0.0989084039596514 no 2992 0.0944354201654066 972 25236497 SGTC_1561 5-methoxyflavone 52.9 µM -1.31600707859526 0.0985612443905326 no 2993 0.0940858334141153 970 94525 SGTC_2743 auranofin 4.32 µM -1.31715385293052 0.0983702514352387 no 2994 0.0938935293474467 976 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2740 felodipine 17.08 µM -1.3226370772939 0.0974607769232324 no 2995 0.0929780489322161 997 3333 L-type calcium channel blocker SGTC_1602 st001878 87.6 µM -1.32604148611202 0.0968992170859614 no 2996 0.092412978068303 993 595405 YLR310C CDC25 SGTC_2717 st081029 62.2815 µM -1.32872411541621 0.0964583916230022 no 2997 0.0919695028948067 981 5292846 SGTC_1663 st014140 55.4 µM -1.32967324979462 0.0963027777008175 no 2998 0.0918129760832351 992 4207120 SGTC_2752 diclazuril 33.15 µM -1.33307122428754 0.0957471805539224 no 2999 0.0912542157622117 968 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3183 9108214 49.47 µM -1.3349603267276 0.0954393183150898 no 3000 0.090944665761 991 4974831 SGTC_2746 daunorubicin 9.88 µM -1.33525362922235 0.095391584969964 no 3001 0.0908966748984127 984 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1495 4469-0029 237 µM -1.33972925518025 0.0946653806525709 no 3002 0.0901666913875486 996 793680 SGTC_1705 st027868 56.3335 µM -1.34213042438577 0.0942774562103032 no 3003 0.0897768553213833 969 292948 SGTC_1814 st052110 31.539 µM -1.34309166457893 0.0941224906988836 no 3004 0.0896211471423928 998 674163 SGTC_500 h-89 112 µM -1.34416329893282 0.0939499497138042 no 3005 0.0894477933938331 1010 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1773 st048542 73.5835 µM -1.34753680918938 0.0934083139354377 no 3006 0.0889037033429343 999 3237138 SGTC_2647 atorvastatin 60.16 µM -1.34937073176951 0.0931148370247514 no 3007 0.0886089584436111 982 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_72 0744-0168 198.391 µM -1.34984584981766 0.0930389166268208 no 3008 0.0885327171291116 1016 677577 SGTC_3330 9141424 71.43 µM -1.35033471804204 0.0929608468209733 no 3009 0.0884543203721685 996 27261020 SGTC_3209 9113616 49.47 µM -1.35203601118251 0.092689536348887 no 3010 0.0881818977731801 1004 16649353 SGTC_2918 7977171 22.06 µM -1.35490448906045 0.0922334181909648 no 3011 0.0877239946203895 981 2236483 SGTC_2292 7671323 168.05 µM -1.35692397750512 0.0919132962793902 no 3012 0.087402683647081 1005 937504 SGTC_2919 7978188 46.38 µM -1.36241182642912 0.0910475399178892 no 3013 0.086533976758872 980 2980291 SGTC_155 k072-0202 43.6 µM -1.36249985956004 0.0910337013808841 no 3014 0.0865200942216362 1002 5857737 SGTC_591 4299-0174 154 µM -1.36293704658025 0.0909650000400152 no 3015 0.0864511759213055 1031 5509088 SGTC_367 0335-0881 7.1 µM -1.3648363430078 0.0906669833636386 no 3016 0.0861522466683362 1023 23828853 SGTC_26 0302-0163 425.158 µM -1.36675832443438 0.0903661455221817 no 3017 0.0858505348410638 1031 3100915 SGTC_2628 lathosterol 100 µM -1.36720164304974 0.0902968604717334 no 3018 0.0857810552490417 999 6710616 SGTC_1832 st054113 55 µM -1.36879233824151 0.0900485798341032 no 3019 0.0855320982709853 995 1251267 SGTC_1903 st060211 78.3 µM -1.36993994036032 0.0898697737609982 no 3020 0.0853528252979059 986 688960 SGTC_1004 4084-0029 199 µM -1.37126626222946 0.0896634505326075 no 3021 0.0851459843813515 1008 716894 YLR208W SEC13 SGTC_1673 st016611 27.3 µM -1.37264366823263 0.089449553639727 no 3022 0.0849315746912233 1025 5226799 SGTC_1906 st060206 94.7 µM -1.37305974797229 0.0893850154611089 no 3023 0.0848668865762194 986 5133468 SGTC_2948 9070189 9.45 µM -1.37331594474542 0.0893452939825759 no 3024 0.084827073920972 958 6473636 YDL196W YDL196W SGTC_2551 apiole 73.87 µM -1.3743842768542 0.0891797982662169 no 3025 0.0846612073990697 995 10659 A possible DNA adduct former. SGTC_1825 st052143 62.6 µM -1.37527154513275 0.0890425247002174 no 3026 0.0845236373828687 1007 674173 SGTC_3290 9121031 71.43 µM -1.38312445980553 0.0878344117552933 no 3027 0.0833133534604227 986 17014854 SGTC_3226 9131256 49.47 µM -1.38356015477754 0.0877677430429841 no 3028 0.0832465879993197 971 17178073 SGTC_1671 st016596 74.5 µM -1.3869101644555 0.0872563952582934 no 3029 0.0827345790077697 1023 2829167 SGTC_2978 9011784 42.97 µM -1.39202830075018 0.0864794593862935 no 3030 0.0819569140738682 974 2994934 SGTC_639 0833-0042 114 µM -1.39642928684843 0.0858155329708947 no 3031 0.0812926304704758 1011 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2850 9015429 58.44 µM -1.39776292224085 0.0856150978173255 no 3032 0.0810921360045967 1013 6457570 SGTC_21 0849-0113 22.993 µM -1.40045946210577 0.0852108998205793 no 3033 0.0806878872605907 1015 1560156 SGTC_2299 7976368 114.88 µM -1.40150096778436 0.0850551666276853 no 3034 0.0805321591755174 1005 2979718 SGTC_2946 9065502 71.43 µM -1.40230574726535 0.0849349765613299 no 3035 0.0804119824605616 953 16489101 SGTC_1456 k015-0012 13 µM -1.40397224496717 0.0846864977558369 no 3036 0.0801635573146686 1009 2989616 SGTC_1917 st066507 28.5 µM -1.40496251972453 0.0845391038665573 no 3037 0.0800162118941431 993 3156428 SGTC_640 3381-0960 37.1 µM -1.40516963338838 0.0845083011248819 no 3038 0.0799854208500324 1015 1745025 SGTC_695 3505-6186 243 µM -1.40582663785868 0.0844106446070378 no 3039 0.0798878050074014 1005 1819379 SGTC_2847 9005661 71.43 µM -1.40748410136588 0.0841646570951365 no 3040 0.0796419441834743 997 2991449 SGTC_1213 1315-0166 115 µM -1.40791384476441 0.0841009659398965 no 3041 0.0795782914952924 989 768401 SGTC_1339 1486-1321 22.7 µM -1.4080310940597 0.0840835950101379 no 3042 0.0795609314619983 1006 3469382 SGTC_3152 9099253 49.47 µM -1.41167855233667 0.0835445545223438 no 3043 0.0790223156462052 979 25236131 SGTC_2478 5763493 32.33 µM -1.41171401309529 0.0835393267214269 no 3044 0.0790170927871499 991 1365576 YLR208W SEC13 SGTC_2744 captopril 92.04 µM -1.41483767462244 0.0830797849940448 no 3045 0.0785580475661244 1027 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2046 4110841 106 µM -1.41879540670479 0.0825002714341719 no 3046 0.0779793361109692 994 44119630 YMR134W ERG29 SGTC_679 0422-0091 41.4 µM -1.41980907199759 0.0823523354933144 no 3047 0.0778316365627776 1020 627384 YHR062C RPP1 SGTC_274 sirtinol 40.1 µM -1.42103035430941 0.0821743650090934 no 3048 0.0776539675909101 1004 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1788 fluconazole 20 µM -1.42511682315742 0.0815809735604031 no 3049 0.0770617172169911 1015 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1424 4048-1941 275 µM -1.42751827775142 0.0812337715733954 no 3050 0.076715280297489 1002 X1424 SGTC_1296 1068-0102 11.9 µM -1.42919734220682 0.0809916757079581 no 3051 0.0764737607002414 1009 767053 SGTC_2391 6285546 200 µM -1.4303879355671 0.0808203402967356 no 3052 0.0763028544576361 1016 846083 SGTC_2338 7999974 200 µM -1.43414661401503 0.0802812335752652 no 3053 0.075765214017167 1002 315925 SGTC_780 0109-0199 192 µM -1.43571741737101 0.0800567403670415 no 3054 0.0755413835124582 994 610414 SGTC_2994 9053520 71.4286 µM -1.43822317818683 0.0796996094757827 no 3055 0.0751853703820518 1010 4647384 SGTC_287 k060-0039 29.6 µM -1.4418412537684 0.0791860753262571 no 3056 0.0746735809796112 1010 5861974 SGTC_244 nsc-207895 1.295 µM -1.44271045898566 0.0790630781216854 no 3057 0.0745510258546326 989 42640 SGTC_1188 1403-0014 4.57 µM -1.4437757665422 0.078912528780924 no 3058 0.0744010303988782 995 9614867 SGTC_1828 st055811 49 µM -1.44418681955549 0.078854496836763 no 3059 0.0743432157213802 1016 5877589 SGTC_1521 st012942 49.4 µM -1.44478188186832 0.0787705439818738 no 3060 0.0742595808888317 1003 24207259 SGTC_1002 4049-0206 172 µM -1.44585608419955 0.0786191643770675 no 3061 0.074108785830483 1003 4662749 SGTC_2359 9039622 200 µM -1.44598264051402 0.078601344234899 no 3062 0.0740910354411653 1036 6463596 SGTC_1499 4480-0877 67.3 µM -1.45280765031836 0.0776448559220698 no 3063 0.0731385836278798 995 2861909 SGTC_2341 7987486 176.74 µM -1.45592130342343 0.077211440637441 no 3064 0.0727071878921549 1010 1258686 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.45808508173033 0.0769113305611101 no 3065 0.0724085464322839 974 4000243 SGTC_1875 nocodazole 6 µM -1.45988735840909 0.0766620373344795 no 3066 0.0721605170563311 1018 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_826 1683-5028 118 µM -1.46066253592341 0.0765550029705088 no 3067 0.0720540375978593 1011 722377 SGTC_1672 st016598 6.51 µM -1.46219414541399 0.0763438567980996 no 3068 0.0718440077619357 1004 4665860 YNL267W PIK1 SGTC_862 0452-0056 10.2 µM -1.46637318427567 0.0757699927861136 no 3069 0.0712733238223897 1040 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1987 st072290 61.9 µM -1.47207489850324 0.074992342621878 no 3070 0.070500326530963 1025 54697379 SGTC_27 0485-0001 32.618 µM -1.47267883269057 0.0749103305895781 no 3071 0.0704188284154049 989 2054479 SGTC_1665 st014639 11.4 µM -1.4730212821416 0.0748638576245893 no 3072 0.0703726486425476 1016 981133 YIL048W NEO1 SGTC_541 4513-1321 94 µM -1.47367034768978 0.0747758349053742 no 3073 0.0702851851697459 998 747515 SGTC_20 0481-0013 4.944 µM -1.4753345006136 0.0745505123845979 no 3074 0.0700613176557809 1000 182045 SGTC_2212 7123476 200 µM -1.4763539522249 0.0744127371616085 no 3075 0.0699244487530661 1027 1085715 SGTC_2523 spermine 47.74 µM -1.47783517520472 0.0742129017330518 no 3076 0.0697259504079789 1007 1103 A DNA binding polyamine. SGTC_269 exalamide 29 µM -1.4787575622925 0.0740886674745933 no 3077 0.0696025608606552 1030 3316 A derivative of salicylamide. SGTC_1346 1488-2224 62.4 µM -1.48326579932897 0.0734837478707041 no 3078 0.0690019026130945 1001 3722427 SGTC_38 0929-0051 58.268 µM -1.48698170111677 0.0729879902102518 no 3079 0.0685098219985807 1015 1379719 SGTC_654 1124-0271 80.9 µM -1.48723187608537 0.0729547052750557 no 3080 0.0684767899348783 1028 5403748 SGTC_2284 7945075 39.21 µM -1.48968838771975 0.0726284915726391 no 3081 0.0681530946553251 1000 1245402 SGTC_1729 st035615 45.989 µM -1.4915259880691 0.0723851977848772 no 3082 0.0679117266924736 1002 17385451 SGTC_1114 scopoletin 1.73284 µM -1.49486644297335 0.0719445297040524 no 3083 0.0674746508008522 1027 5280460 A coumarin with genotoxic properties. SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.4960477667685 0.0717891844672904 no 3084 0.0673206039917588 1042 688801 SGTC_1362 1611-0397 101 µM -1.50141562123247 0.0710865450611075 no 3085 0.0666240479972249 1023 27816 SGTC_943 3253-1379 105 µM -1.50359050654724 0.0708033657380869 no 3086 0.0663434185237644 1005 668464 SGTC_988 1497-1057 103 µM -1.50386912123056 0.070767151635743 no 3087 0.0663075345939353 1025 3533044 SGTC_382 3229-0966 23.2 µM -1.50459066964017 0.0706734315360586 no 3088 0.0662146732758549 1034 5722370 SGTC_3144 9087057 49.47 µM -1.50562032958272 0.0705398568201269 no 3089 0.0660823333095381 1001 17249618 SGTC_545 4218-0007 221 µM -1.50911402829859 0.0700880757343831 no 3090 0.0656348226016422 1026 2840508 SGTC_3119 9125183 49.47 µM -1.51182342053094 0.069739250787374 no 3091 0.0652893948201567 1008 22695334 SGTC_1100 amiodarone 5.07 µM -1.51395967326889 0.0694651590186003 no 3092 0.0650180338815167 1013 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_603 3794-0023 45.9 µM -1.51454448562257 0.0693902695376263 no 3093 0.0649438999874144 1037 3802260 SGTC_2519 cryptotanshinone 88.04 µM -1.51542378156288 0.0692777863489331 no 3094 0.0648325593213028 1004 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2804 7954240 19.48 µM -1.51550353559603 0.0692675908339668 no 3095 0.064822467818837 1015 828705 SGTC_2980 9014342 25.29 µM -1.51641578984645 0.0691510532178055 no 3096 0.0647071244613912 986 2996599 SGTC_775 4577-0580 57.3 µM -1.51701326315088 0.0690748097930319 no 3097 0.0646316677137842 1031 2006902 SGTC_564 3555-0129 330 µM -1.5209960111896 0.068568226490522 no 3098 0.0641304191521729 996 563260 SGTC_410 α-linolenic acid 100 µM -1.52114718139998 0.0685490550844567 no 3099 0.0641114533306784 1030 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_63 0099-0242 26.702 µM -1.52925052993152 0.067527427361096 no 3100 0.0631011741634007 1022 3898502 YLR359W ADE13 SGTC_529 4076-0302 30.3 µM -1.53077400386075 0.0673366764623886 no 3101 0.0629126282944484 1028 5816522 SGTC_3118 9124250 49.47 µM -1.5324580929269 0.0671263002792671 no 3102 0.0627047156840641 1003 1504786 SGTC_853 0419-0306 21 µM -1.53902677298409 0.0663105961366256 no 3103 0.0618988801370756 1027 762713 SGTC_2508 celastrol 40.54 µM -1.53950402442028 0.066251631085334 no 3104 0.0618406480825667 988 122724 Celastrol is a natural product and antioxidant. SGTC_3178 9107506 49.47 µM -1.54409771222009 0.065686149501085 no 3105 0.0612823315068125 1020 8897194 SGTC_1293 1000-1278 195 µM -1.54492429835124 0.0655847953957241 no 3106 0.0611822876650767 1029 678847 SGTC_2157 5649910 96.377 µM -1.5479106509177 0.0652196258896072 no 3107 0.0608219049640552 1030 2858091 SGTC_1315 1237-0019 3.69 µM -1.55037056576059 0.0649200154754708 no 3108 0.0605262995456338 1004 825140 SGTC_2845 9003024 42.97 µM -1.55095262539465 0.064849278881833 no 3109 0.0604565187595326 1012 2990173 SGTC_312 4092-0653 6.84 µM -1.55112864784558 0.0648278989989252 no 3110 0.0604354285381939 999 1148278 SGTC_1201 1889-3372 45.9 µM -1.55200791509165 0.0647211841573925 no 3111 0.0603301648696228 1014 5392199 SGTC_503 tyrphostin 8 294 µM -1.55220009360442 0.0646978780267215 no 3112 0.0603071768603759 1046 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.55262509395572 0.0646463599587068 no 3113 0.060256363514089 1008 6708630 An antioxidant. SGTC_2221 6807166 181.081 µM -1.5575555369804 0.0640510235484783 no 3114 0.0596693228541653 1030 674925 SGTC_610 4215-0184 155 µM -1.56042318488107 0.0637067293063518 no 3115 0.0593299547167918 983 5605015 SGTC_1326 1431-2094 10.8 µM -1.56084060187896 0.0636567338419484 no 3116 0.0592806824570005 1024 616278 SGTC_3202 9113761 49.47 µM -1.56560602375918 0.0630881242828836 no 3117 0.0587204394563101 1025 4798415 SGTC_1050 3232-1156 69.3 µM -1.56943843011254 0.0626337182483063 no 3118 0.0582729076690729 1032 700529 SGTC_1971 st069429 63.5 µM -1.57210323360265 0.0623192607008439 no 3119 0.0579633058570684 1025 1246522 YGL099W LSG1 SGTC_2896 9052656 71.43 µM -1.57385150432802 0.0621136274869272 no 3120 0.0577608918430286 988 6469436 SGTC_1176 0848-0131 83.3 µM -1.57403594724949 0.06209196404655 no 3121 0.0577395695725298 1033 6769040 SGTC_3068 9116768 49.47 µM -1.57599641423078 0.0618620647861057 no 3122 0.0575133147949513 1031 41904888 SGTC_2854 9024559 71.43 µM -1.57613761943578 0.0618455316746966 no 3123 0.0574970454601689 1020 3163529 SGTC_1678 st019265 80.2 µM -1.5781718920352 0.0616077299910954 no 3124 0.0572630628609053 1030 5367020 SGTC_3168 9103419 49.47 µM -1.57852861474107 0.061566103623291 no 3125 0.0572221098448707 1039 16649256 SGTC_1861 st057647 17.4 µM -1.58258461689553 0.061094347470656 no 3126 0.0567580859899951 1032 688668 SGTC_3177 9107506 49.47 µM -1.58352151545626 0.0609857789343741 no 3127 0.0566513233520365 1039 8897194 SGTC_2390 9097792 176.6 µM -1.58375257197791 0.0609590271224716 no 3128 0.0566250180454528 1025 4497149 SGTC_43 0570-0105 72.5 µM -1.58435650176114 0.0608891472290135 no 3129 0.0565563073383512 1021 1114046 YDL195W SEC31 SGTC_933 2914-0560 114 µM -1.5851042466083 0.0608027134891161 no 3130 0.0564713254522628 1019 463887 SGTC_763 3453-1109 128 µM -1.58820769390096 0.0604450031851178 no 3131 0.0561196909485883 1031 1560353 SGTC_2474 5321570 43.32 µM -1.59749823643294 0.0593839928495474 no 3132 0.0550773452409435 1044 2841384 SGTC_1952 st077036 64.1 µM -1.59817014419034 0.0593078285507713 no 3133 0.0550025581333708 1015 2937007 SGTC_1106 tegaserod maleate 11.7 µM -1.59989255788778 0.0591129336706296 no 3134 0.0548112102927205 1013 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_3160 9100216 49.47 µM -1.6065798080893 0.0583610143168445 no 3135 0.054073287427034 1033 17191039 SGTC_1434 4073-0095 163 µM -1.6077241839491 0.0582330959099637 no 3136 0.0539477997640564 1032 24133745 SGTC_232 clozapine 119 µM -1.60897957128396 0.0580930220919405 no 3137 0.0538104043328893 1043 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.60904584316158 0.05808563496089 no 3138 0.0538031589374174 1041 688662 SGTC_2435 5706476 10.6 µM -1.61092544205424 0.0578764287953975 no 3139 0.0535979869696717 1019 5725375 SGTC_716 1683-5115 658 µM -1.61174122805096 0.0577858133872764 no 3140 0.053509131064523 1026 723597 SGTC_1445 4239-0156 97.7 µM -1.61849831379823 0.0570395357643725 no 3141 0.0527776249616061 1054 4008346 SGTC_1809 st050081 57.6 µM -1.61851979827194 0.0570371750984766 no 3142 0.0527753118209193 1039 5036894 SGTC_2215 7188065 200 µM -1.61908871041126 0.0569746922865903 no 3143 0.0527140887624164 1042 940217 SGTC_2707 st078556 66.6 µM -1.61927928749996 0.0569537735306078 no 3144 0.052693592555597 1015 17250899 SGTC_1284 0929-0043 16 µM -1.6196490266578 0.0569132062404295 no 3145 0.05265384584139 1034 1239883 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.62560468157295 0.0562628899266315 no 3146 0.0520168893318643 1038 551469 SGTC_2305 7443522 69.23 µM -1.63228607053704 0.0555403164106123 no 3147 0.0513096181234539 1022 5415886 SGTC_973 1325-0077 65.9 µM -1.63271292819349 0.0554944030649151 no 3148 0.0512646935574523 1051 2835149 SGTC_2199 6590217 200 µM -1.63745046673905 0.0549868369197511 no 3149 0.0507681903524113 999 703109 SGTC_2269 7935389 174.42 µM -1.64062813137013 0.0546484515401464 no 3150 0.050437315876152 1023 97605 SGTC_19 0279-0214 38.434 µM -1.64456422118388 0.0542315877297837 no 3151 0.0500298551541648 1050 3566274 YBR002C RER2 SGTC_798 1287-0182 476 µM -1.65807084533319 0.0528202307076755 no 3152 0.0486515838472754 1059 1649755 SGTC_1048 3161-0300 24.5 µM -1.65959381876505 0.0526629345706334 no 3153 0.048498096337942 1026 2165101 SGTC_1247 0448-0043 5.84 µM -1.65997779859386 0.0526233349968164 no 3154 0.0484594594666917 1045 3089013 YGL099W LSG1 SGTC_2035 5154463 94.595 µM -1.66162527459392 0.052453700068516 no 3155 0.0482939662027971 1042 2769623 SGTC_224 benfluorex 43.875 µM -1.66184629266444 0.0524309756608952 no 3156 0.0482717987964317 1057 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_944 3370-0224 231 µM -1.66694542465609 0.0519088653426833 no 3157 0.0477626286666161 1030 4580514 SGTC_32 0928-0142 34.1 µM -1.67103773274153 0.0514928411988834 no 3158 0.0473571125240628 1033 2244242 SGTC_2045 5106652 78.05 µM -1.67511042553269 0.0510814479664681 no 3159 0.0469562839049438 1020 673349 SGTC_3293 9120939 62.045 µM -1.6753352298913 0.0510588162935575 no 3160 0.0469342384552821 1041 934087 SGTC_1053 3366-3204 134 µM -1.68672805360667 0.0499222822625001 no 3161 0.0458278276034319 1041 3632071 YPR165W RHO1 SGTC_2819 7996655 46.38 µM -1.68942902682048 0.0496558172080908 no 3162 0.0455686211435225 1031 6456960 SGTC_124 0136-0217 7.121 µM -1.69912421016547 0.0487086733145769 no 3163 0.0446478913202786 1030 3976905 SGTC_2262 9014885 67.46 µM -1.70227556505765 0.048403939119919 no 3164 0.0443518615691535 1065 6457424 SGTC_945 3381-0768 11.3 µM -1.70308513094812 0.0483259012383519 no 3165 0.0442760690571737 1051 1126236 YIL048W NEO1 SGTC_3083 9117465 49.47 µM -1.70385026465126 0.0482522389213205 no 3166 0.0442045323282987 1043 16420915 SGTC_2220 6782180 200 µM -1.70444102315428 0.0481954258387761 no 3167 0.0441493626985462 1036 833803 SGTC_418 lividomycin a 100 µM -1.70726351321604 0.047924726061067 no 3168 0.0438865423021983 1043 72394 An antibiotic. SGTC_2828 7998861 71.43 µM -1.70743088546831 0.0479087120035567 no 3169 0.0438709969045012 1023 2988188 SGTC_844 0330-0132 15.3 µM -1.70861356288406 0.0477956763159112 no 3170 0.0437612773327486 1043 2828079 SGTC_1922 5578187 25 µM -1.71600995330045 0.0470935938915021 no 3171 0.0430801103551185 1012 1350412 SGTC_433 pimozide 108 µM -1.7209816706528 0.0466263313429177 no 3172 0.0426270750069583 1051 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3236 9132701 49.47 µM -1.72102927897647 0.0466218749646343 no 3173 0.0426227555091058 1055 24282524 SGTC_1240 0356-0016 42.1 µM -1.72569423536566 0.0461868664935372 no 3174 0.0422012178391067 988 4305613 SGTC_2848 9016370 25.97 µM -1.72636438178211 0.0461246437904438 no 3175 0.0421409397220091 1042 7894410 SGTC_2010 4012422 159 µM -1.7290995084486 0.0458713867230416 no 3176 0.0418956435672675 1038 952393 SGTC_682 0kpi-0099 17 µM -1.73205807342283 0.0455986998764254 no 3177 0.0416316115581905 1046 1714895 YML126C ERG13 SGTC_2258 7960471 200 µM -1.74275982546908 0.0446232004497441 no 3178 0.0406877883017639 1063 2974708 SGTC_1096 rimcazole 32.2 µM -1.74499204972756 0.0444218599798925 no 3179 0.0404931264343071 1041 18528119 A dopamine reuptake inhibitor. SGTC_3277 9138724 49.47 µM -1.74952452390112 0.0440152955561309 no 3180 0.0401001967371743 1055 15943418 SGTC_2820 7989630 71.43 µM -1.75058349424159 0.0439207393044164 no 3181 0.0400088402418566 1034 2984098 SGTC_2461 5755302 26.15 µM -1.75284174672549 0.0437196454521081 no 3182 0.0398145875377521 1058 2788904 SGTC_2184 6075246 200 µM -1.75465512133179 0.0435587056127736 no 3183 0.039659158422377 1046 2267320 SGTC_1812 st052057 4.327 µM -1.75483232994145 0.0435430037509675 no 3184 0.0396439959064843 1054 3645418 SGTC_2995 9067767 71.4286 µM -1.76011304845319 0.0430771896916658 no 3185 0.0391943204043524 1041 11673567 SGTC_851 0394-0702 453 µM -1.76512987416299 0.0426383905973467 no 3186 0.0387709704500141 1055 762646 SGTC_2588 indole-3-carbinol 100 µM -1.77427478281709 0.0418478286035883 no 3187 0.0380088548107694 1039 3712 Induces cell cycle arrest. SGTC_3086 9117350 49.47 µM -1.77625323334466 0.0416783662117273 no 3188 0.037845593847209 1038 2679265 SGTC_1008 4106-0037 6 µM -1.78194535744649 0.0411939107264071 no 3189 0.0373790714640386 1043 2905394 SGTC_2708 st078559 56 µM -1.78902876018704 0.0405974302808454 no 3190 0.0368050919495413 1030 17250902 SGTC_42 0133-0086 60.653 µM -1.80523650364055 0.0392589599366412 no 3191 0.0355188404913254 1041 162923 Model of phenazepam hydroxylation. SGTC_1913 st060213 96.1 µM -1.8089886201289 0.0389542773962185 no 3192 0.0352263856556481 1052 688959 SGTC_2543 pimpinellin 60.67 µM -1.81362590240209 0.038580380217814 no 3193 0.0348676699136824 1049 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_968 1309-0633 340 µM -1.81498480420336 0.0384713697266805 no 3194 0.0347631223796537 1045 3761976 SGTC_865 0488-0499 301 µM -1.81826589563393 0.0382091967042764 no 3195 0.0345117513466396 1042 9634651 SGTC_2158 5657123 3.6195 µM -1.82196344259504 0.0379154951567291 no 3196 0.0342302663987038 1064 2858827 SGTC_969 1313-0238 134 µM -1.82993542002487 0.0372885350332748 no 3197 0.0336297981083164 1036 5212874 SGTC_3262 9137218 49.47 µM -1.83110968390667 0.0371969042233887 no 3198 0.033542086702844 1044 17650664 SGTC_61 0978-8327 98.565 µM -1.83724221006696 0.0367213525667381 no 3199 0.0330870734656823 1035 6150059 YHR072W ERG7 SGTC_3024 9090631 49.47 µM -1.84409406154914 0.0361959140268701 no 3200 0.0325847166129221 1040 25236383 SGTC_1923 st058458 19.1 µM -1.84419031350976 0.0361885769601706 no 3201 0.0325777047697108 1049 3534982 SGTC_3044 9093193 49.47 µM -1.84484395612588 0.0361387834864838 no 3202 0.0325301205816327 1049 25236277 SGTC_2393 9031399 185.94 µM -1.8458242691137 0.0360642099505863 no 3203 0.0324588627689017 1057 1526623 YDL150W RPC53 SGTC_696 1560-0013 611 µM -1.85433699680042 0.0354219218527173 no 3204 0.0318454811376371 1057 1650269 SGTC_1196 1588-0294 184 µM -1.86984144114532 0.034276216416548 no 3205 0.030752919828088 1064 6144269 SGTC_2186 6124449 200 µM -1.87102926394933 0.0341897126794176 no 3206 0.0306705124688906 1049 3834182 YLR033W RSC58 SGTC_2748 diazoxide 86.69 µM -1.87216294583651 0.0341073192411336 no 3207 0.0305920318631944 1059 3019 A potassium channel activatior. SGTC_3291 9121177 71.43 µM -1.875225185476 0.033885578353277 no 3208 0.0303808753647134 1058 17015612 SGTC_2415 st077333 57.7 µM -1.87969233804323 0.0335642337474305 no 3209 0.030075010208104 1039 2766255 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.87984664573372 0.0335531785983037 no 3210 0.0300644905742992 1043 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1652 st011932 78 µM -1.89252449716022 0.0326550795263136 no 3211 0.0292105664364709 1043 1551076 SGTC_848 0368-0089 85.6 µM -1.89373244098446 0.0325705530168029 no 3212 0.0291302665025547 1055 762535 SGTC_2794 7785382 27.27 µM -1.90049229891869 0.0321008528888681 no 3213 0.0286842723253399 1030 2205081 SGTC_1275 0867-0008 21.1 µM -1.90966162192835 0.0314726850990223 no 3214 0.0280883976903061 1065 3422836 SGTC_2667 digitoxin 100 µM -1.91489331801595 0.0311188506591786 no 3215 0.0277530550755324 1055 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2866 9034245 58.44 µM -1.91764329530334 0.0309341854401934 no 3216 0.0275781281831703 1059 6462273 SGTC_1803 st050068 52.4 µM -1.91788156434412 0.030918228090302 no 3217 0.0275630151792015 1045 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3164 9100705 49.47 µM -1.9189942813453 0.0308437973997874 no 3218 0.0274925287903371 1051 17174235 SGTC_1417 3966-0327 90.4 µM -1.92068581366058 0.0307309333720585 no 3219 0.0273856645790062 1062 651118 SGTC_1265 0819-1001 68.8 µM -1.93069229032749 0.0300702458455267 no 3220 0.0267605584558617 1067 3106768 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.93531511140623 0.0297690206482026 no 3221 0.0264758195414787 1037 279621 SGTC_2960 9079389 5.97 µM -1.93966297345291 0.0294880006465361 no 3222 0.026210331111663 1052 16457355 SGTC_2902 5787006 60.46 µM -1.94728126369138 0.0290009106130537 no 3223 0.0257505118559054 1048 591003 SGTC_2747 doxorubicin 7.63 µM -1.95123015435467 0.0287510734407224 no 3224 0.0255148367115181 1046 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2898 9056270 58.44 µM -1.95273635444993 0.0286562523073719 no 3225 0.0254254217802538 1036 19154699 SGTC_2861 9024595 19.48 µM -1.95609152677855 0.0284459658725003 no 3226 0.0252271865659718 1067 16482810 SGTC_3176 9106582 49.47 µM -1.95900743675483 0.0282642546042252 no 3227 0.0250559579321031 1068 17018027 SGTC_2148 5546263 113.568 µM -1.9591593298745 0.0282548155898912 no 3228 0.0250470651963886 1066 792097 SGTC_2150 5556613 200 µM -1.96361687320029 0.0279789789830804 no 3229 0.0247872695748528 1067 743190 SGTC_3342 9147791 14.508 µM -1.96559086515504 0.0278575451381261 no 3230 0.0246729450750767 1060 1838168 SGTC_2545 solidagenone 89.61 µM -1.96622222088701 0.0278187988927166 no 3231 0.0246364733717291 1065 6708572 An anti ulcer agent SGTC_1630 st005209 31.3 µM -1.9680070301039 0.0277095081133657 no 3232 0.0245336144168214 1034 3367314 SGTC_1882 5615643 20 µM -1.98374987054117 0.0267609238631912 no 3233 0.0236418655123568 1041 2253075 SGTC_3034 9090421 49.47 µM -1.98516355537809 0.0266770854379019 no 3234 0.0235631388074964 1062 17173761 SGTC_666 0272-0154 136 µM -1.98561828452705 0.0266501644518208 no 3235 0.0235378623127037 1082 6870312 SGTC_1948 st076329 66.6 µM -1.99401698606007 0.0261570085652685 no 3236 0.0230750991260938 1060 24208413 SGTC_2638 epoxomicin 18 µM -1.99440902014159 0.0261341767274748 no 3237 0.023053686783475 1065 9915668 A protesome inhibitor. SGTC_2115 tiliquinol 12.7705 µM -1.99813306597209 0.025918120402976 no 3238 0.0228511178788972 1062 71208 A bioactive hydroxyquinoline. SGTC_1916 st067606 49.2 µM -1.99845088591938 0.025899750995337 no 3239 0.0228338997800739 1042 19590279 SGTC_2113 5491891 107.031 µM -2.00190063947482 0.0257010614880642 no 3240 0.02264770943926 1055 789979 SGTC_2048 5246248 200 µM -2.00345806831559 0.0256117798582192 no 3241 0.0225640720186134 1059 677046 SGTC_2791 5663188 71.43 µM -2.00352942563216 0.0256076954363449 no 3242 0.022560246218009 1057 54690634 SGTC_2644 guaiazulene 100 µM -2.00386096885563 0.025588725384256 no 3243 0.0225424778029268 1065 3515 A coloring agent. SGTC_2648 atorvastatin 78.68 µM -2.00859751825732 0.0253189945148049 no 3244 0.0222899173643203 1068 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2 0422-0095 29 µM -2.01082022193992 0.0251932423958146 no 3245 0.0221722246831822 1049 6790840 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.0161122071469 0.024895947257094 no 3246 0.0218941219298195 1045 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_565 1418-0001 44.5 µM -2.02016217126716 0.0246704190563835 no 3247 0.0216832843632103 1073 2862145 SGTC_1435 4092-0789 56.7 µM -2.02480643769889 0.0244139086205597 no 3248 0.0214436218890973 1062 2248285 SGTC_3039 9090270 49.47 µM -2.03115937249676 0.0240666549457472 no 3249 0.0211194151073063 1055 17173750 SGTC_1103 duloxetine 36.1 µM -2.04055899172477 0.0235604869536008 no 3250 0.0206473408968932 1077 60835 A selective serotonin reuptake inhibitor. SGTC_3021 9087658 49.47 µM -2.04493591237928 0.0233278636861787 no 3251 0.0204305884006717 1069 25237042 SGTC_1969 st069479 40.1 µM -2.0474407825753 0.0231956073911718 no 3252 0.0203074127836785 1063 3895485 SGTC_974 1326-0144 138 µM -2.04746476666582 0.0231943440967107 no 3253 0.0203062364285896 1069 5411856 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -2.05589368159337 0.0227539475260506 no 3254 0.0198963826431705 1052 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2550 chrysin dimethyl ether 71.87 µM -2.06029916095963 0.0225265865853114 no 3255 0.0196849750482635 1055 88881 An O-methylated flavonoid and antioxidant. SGTC_3271 9137798 49.47 µM -2.06618247901404 0.0222259461346695 no 3256 0.0194056262985669 1055 6498326 SGTC_2430 5571206 200 µM -2.07617137955221 0.0217232629257893 no 3257 0.0189390516542192 1062 1731771 SGTC_2602 kawain 100 µM -2.0825495362192 0.0214073383730904 no 3258 0.0186461515661096 1053 5369129 SGTC_1793 st048256 72.231 µM -2.10530584979493 0.0203116369599827 no 3259 0.0176323466189903 1063 672022 SGTC_790 1575-0012 79.1 µM -2.10877851958203 0.0201486846080351 no 3260 0.017481851781787 1046 378741 YLR208W SEC13 SGTC_2986 9022445 71.43 µM -2.12715997827902 0.0193044987486646 no 3261 0.0167033965953956 1047 6459286 SGTC_2103 5378138 10 µM -2.13029383106429 0.0191636150605652 no 3262 0.0165736812702235 1074 244142 SGTC_1736 st036774 51 µM -2.13282556296792 0.0190504391521488 no 3263 0.0164695192121941 1064 1272247 SGTC_3111 9122088 49.47 µM -2.14943238483315 0.0183220683915584 no 3264 0.0158000702971101 1078 16876704 SGTC_2075 5212009 200 µM -2.15596290065388 0.0180422119947928 no 3265 0.0155432810840815 1074 780898 SGTC_1359 1582-0056 520 nM -2.15773424715551 0.0179669346161289 no 3266 0.0154742498320113 1083 3661189 SGTC_310 1273-0058 1.06 µM -2.15816446249981 0.0179486921166682 no 3267 0.01545752366015 1018 2734232 SGTC_1634 st006576 41 µM -2.15874346990653 0.017924165295835 no 3268 0.0154350371624792 1069 3915356 SGTC_3313 9133968 57.047 µM -2.16118933581799 0.0178208732758007 no 3269 0.015340358425475 1054 1494643 SGTC_2175 5807670 165.306 µM -2.17275763673765 0.0173391827361918 no 3270 0.0148992816358207 1064 241186 SGTC_3073 9114972 49.47 µM -2.1809949163454 0.0170030091285429 no 3271 0.0145918962468255 1076 41905075 SGTC_2763 lisinopril 49.32 µM -2.18758031562713 0.016738273454677 no 3272 0.0143500934913513 1059 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2770 toltrazuril 17.5 µM -2.19046396450801 0.0166234643986794 no 3273 0.0142453027356077 1054 68591 Kills coccidiodes. SGTC_2032 5185112 25.99 µM -2.19917846155516 0.0162805938319257 no 3274 0.0139326176049029 1075 5718189 SGTC_2187 6125751 200 µM -2.21254110077454 0.0157666137421852 no 3275 0.0134646497933109 1083 874498 SGTC_690 glyoxal 20.3 µM -2.21883181746661 0.0155295063287085 no 3276 0.0132490842615905 1063 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_293 4049-0273 38.5 µM -2.21921261160126 0.0155152523340594 no 3277 0.0132361317385792 1068 1380311 SGTC_3322 9139058 2.11 µM -2.22613071013391 0.015258240654826 no 3278 0.0130027137238852 1076 4908926 YPR165W RHO1 SGTC_2934 9036370 36.88 µM -2.24409820923329 0.0146077562410521 no 3279 0.0124130415834078 1066 6462800 SGTC_1666 st014829 29 µM -2.24591065325471 0.0145434843967449 no 3280 0.0123548656896033 1084 3858230 SGTC_1988 st071872 53.4 µM -2.2604144162495 0.0140378710391573 no 3281 0.0118977713023501 1081 16414116 SGTC_1654 st012436 41.8 µM -2.26499365461572 0.013881414480423 no 3282 0.0117565344537969 1084 4323132 SGTC_359 0081-0058 15.9 µM -2.27748679638501 0.0134621925353237 no 3283 0.0113785861046595 1067 3494159 SGTC_1698 5-fluorocytosine 1.055 µM -2.28169319613735 0.0133235233373922 no 3284 0.0112537300288746 1071 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2439 5492030 7.2 µM -2.29776954534348 0.0128048542286064 no 3285 0.0107874544835277 1065 5722370 SGTC_506 n9-isopropylolomoucine 153 µM -2.30569123894454 0.0125557655174946 no 3286 0.0105639455004256 1082 6610355 SGTC_759 3486-0358 89.3 µM -2.30619963668561 0.0125399237537374 no 3287 0.0105497399405531 1081 875103 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -2.31109277455146 0.0123883353877955 no 3288 0.0104138655035438 1060 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3048 9093155 49.47 µM -2.31300500484245 0.0123295276781259 no 3289 0.0103611819870748 1074 25236002 SGTC_1301 naphtanilide LB 4.81 µM -2.32355403471804 0.0120094366135162 no 3290 0.0100747042107715 1067 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1338 1486-1223 76 µM -2.35224647581424 0.0111750163686391 no 3291 0.00933020273783297 1072 3444526 SGTC_1311 1190-0148 100 µM -2.36361946941629 0.0108584943872527 no 3292 0.0090486952826007 1082 1961333 SGTC_1340 1486-1359 257 µM -2.3883589370272 0.0101968037132321 no 3293 0.00846190193869009 1076 4309068 SGTC_2002 4023503 131 µM -2.41313686608114 0.0095696153432964 no 3294 0.00790793962841026 1076 4736863 YCR052W RSC6 SGTC_3309 9129340 25.759 µM -2.42035368727869 0.00939340019743572 no 3295 0.0077527088406396 1077 17158987 SGTC_3205 9113483 49.47 µM -2.42837666548119 0.00920083846673021 no 3296 0.00758329130839677 1072 17018033 SGTC_3096 9117468 49.47 µM -2.45183268307079 0.00865754399128642 no 3297 0.00710653666959044 1081 41316311 SGTC_2027 5150920 200 µM -2.47865512439345 0.0080709384404319 no 3298 0.00659393755447619 1082 786715 SGTC_1984 st072354 53.1 µM -2.49433801834128 0.00774438869851549 no 3299 0.00630961543529601 1074 5762938 SGTC_2949 9072542 2.23 µM -2.50383891404078 0.00755226661754269 no 3300 0.00614269771940613 1077 16457352 SGTC_1938 st074717 56.4 µM -2.5113149240348 0.00740405437293693 no 3301 0.00601411694722793 1068 17250979 SGTC_863 0466-0191 129 µM -2.51547152375343 0.00732276331413521 no 3302 0.00594366399172302 1087 765160 YPR165W RHO1 SGTC_1508 1080-0625 72.9 µM -2.51956248617524 0.00724352520273848 no 3303 0.0058750391367677 1057 767111 SGTC_822 1487-0950 154 µM -2.53217413672903 0.00700398731134007 no 3304 0.00566788397830243 1073 1958375 SGTC_1280 0880-0253 10.1 µM -2.53817134526748 0.0068925532549581 no 3305 0.00557167058390764 1082 6836607 SGTC_2063 5246145 200 µM -2.54689190468324 0.00673331035780858 no 3306 0.00543435471041962 1088 711240 SGTC_1432 4049-0298 68.4 µM -2.54908341447778 0.00669380676671539 no 3307 0.00540032316168435 1086 741646 SGTC_2025 5147754 141 µM -2.54951766498523 0.00668600343936351 no 3308 0.00539360229939794 1073 315777 YLR208W SEC13 SGTC_2201 6605497 169.863 µM -2.55021240498925 0.00667353592873749 no 3309 0.00538286532420787 1089 670741 SGTC_803 4488-1585 147 µM -2.56560741236869 0.00640248656131626 no 3310 0.00514976633905331 1075 747204 SGTC_2584 androsterone 48.74 µM -2.56940712546845 0.00633710526809543 no 3311 0.00509363474175424 1050 2754130 A steroid. SGTC_3261 9137475 49.47 µM -2.58158954324163 0.00613145092584834 no 3312 0.00491732374004437 1087 17027690 SGTC_2640 pentamidine 10.38 µM -2.58304533478151 0.00610727521157709 no 3313 0.00489662267118256 1036 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3297 9117502 71.43 µM -2.58493024014406 0.00607609888120152 no 3314 0.00486993507867263 1087 7453720 SGTC_3327 9140648 26.9345 µM -2.60442787884486 0.00576178997513997 no 3315 0.0046013893536707 1077 8029710 SGTC_1314 1222-0010 41.1 µM -2.61497012176174 0.00559792729685565 no 3316 0.00446176305791014 1086 3526027 SGTC_119 0121-0043 24.815 µM -2.64719034827209 0.00512247367869644 no 3317 0.00405818266308752 1080 1092378 SGTC_1309 pyrazolanthrone 13.4 µM -2.65143611728562 0.00506258008394011 no 3318 0.00400751368127873 1091 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1041 0206-0046 107 µM -2.65173600539172 0.0050583733383307 no 3319 0.00400395632875722 1089 50494 SGTC_2076 5212012 200 µM -2.65391095249169 0.00502795682834021 no 3320 0.00397824103062318 1083 604802 SGTC_35 0133-0054 64.071 µM -2.67043198719001 0.00480217938910195 no 3321 0.00378768583318347 1076 99677 SGTC_2685 mycophenolic acid 18.85 µM -2.68782298098363 0.00457432073124117 no 3322 0.00359597559982354 1085 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_4 0960-0234 25.671 µM -2.72623297235556 0.00410493484931005 no 3323 0.00320308819710042 1072 6821112 SGTC_2914 7968218 45.32 µM -2.7298888593952 0.00406258676831749 no 3324 0.00316778403339528 1083 2977111 SGTC_2384 9036245 200 µM -2.74504786682349 0.00389113432586238 no 3325 0.00302510361312893 1081 6462766 SGTC_1924 st058459 75.1 µM -2.75176652698831 0.00381723996127934 no 3326 0.00296373817579794 1085 688683 SGTC_3071 9117417 49.47 µM -2.78160133747411 0.00350407537133572 no 3327 0.00270457201981551 1084 45595590 YGL055W OLE1 SGTC_797 k781-0471 270 µM -2.78468038916446 0.00347310671196381 no 3328 0.00267902541216531 1084 23738129 SGTC_2107 5363541 170.161 µM -2.79446997966815 0.00337627116224576 no 3329 0.00259924335760385 1092 244052 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -2.80986306006905 0.0032289087265945 no 3330 0.00247812916089279 1090 17037758 SGTC_1343 1487-0095 224 µM -2.82241691113271 0.00311303893739644 no 3331 0.00238315854637445 1089 4560101 YGL055W OLE1 SGTC_1946 st076057 65.1 µM -2.83326690935365 0.00301592600714484 no 3332 0.0023037448345647 1089 953009 SGTC_2431 5490079 200 µM -2.87270847910216 0.00268547555492031 no 3333 0.0020348473053213 1090 5722345 SGTC_1291 0993-0025 5.79 µM -2.91067159343369 0.0023986610500962 no 3334 0.00180326435354232 1083 4353356 SGTC_2639 lactacystin 53 µM -3.0111788100421 0.00176819526828262 no 3335 0.00130117778112261 1085 3870 A proteasome inhibitor. SGTC_3308 9128332 17.569 µM -3.06092097078678 0.00151565424810483 no 3336 0.00110328663844227 1088 17332805 YDL196W YDL196W SGTC_2380 9035439 200 µM -3.08468906708103 0.00140700245849168 no 3337 0.0010188252664338 1089 6462575 SGTC_2121 5257820 149.641 µM -3.10253140457325 0.00133016593168898 no 3338 0.00095936594399024 1092 791256 SGTC_1334 1486-0610 236 µM -3.10686091875362 0.00131210888571978 no 3339 0.000945426678651934 1090 3742339 SGTC_1641 st009299 47.1 µM -3.12633525962792 0.00123362601771305 no 3340 0.000884998208902007 1093 4046054 SGTC_2940 9060638 45.86 µM -3.24927855759905 0.000829501042805181 yes 3341 0.000578490601033125 1087 4027022 SGTC_3314 9135860 59.4275 µM -3.25251694175466 0.000820730327109502 yes 3342 0.000571938882901913 1084 25252478 SGTC_376 3970-0862 59.1 µM -3.32433345732955 0.000646867496876563 yes 3343 0.000443150760909795 1089 3135186 SGTC_3069 9117009 49.47 µM -3.33861771672754 0.000616626201767494 yes 3344 0.000420981736990411 1090 41904981 SGTC_2808 7946468 45.46 µM -3.43079022566643 0.000450826070422479 yes 3345 0.000300912902297535 1092 2970879 SGTC_2204 7233102 200 µM -3.47633509538439 0.000385145014190596 yes 3346 0.000254158362293944 1094 2172480 SGTC_1935 st074532 41.6 µM -3.59576745382473 0.00025269271699177 yes 3347 0.000161718317502155 1092 2829742 SGTC_1248 0469-0687 58.6 µM -3.62727614409637 0.000225636430118316 yes 3348 0.000143213457712952 1093 4017482 SGTC_377 3970-0964 33.1 µM -3.99844906981935 5.56868455070047e-05 yes 3349 3.18794482454652e-05 1094 16481235 SGTC_2839 9003951 25.97 µM -4.00397606190326 5.44890489842872e-05 yes 3350 3.1143335074894e-05 1095 2990634 SGTC_120 rhodamine 6G 52.259 µM -4.19982615428753 2.47839043657917e-05 yes 3351 1.33559997573085e-05 1093 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2932 9016711 44.54 µM -4.25498837453092 1.9731641958957e-05 yes 3352 1.04529938556645e-05 1094 7117328 SGTC_1379 2144-0755 36.5 µM -4.27779514289288 1.79427644989003e-05 yes 3353 9.43768022834475e-06 1093 5392327 SGTC_2809 7964133 12.99 µM -5.79103052815009 1.16931838019305e-08 yes 3354 3.49779295132771e-09 1095 1253665 SGTC_1044 1222-0021 1.78 µM -6.57571671425241 1.16373679803092e-10 yes 3355 2.42096819291223e-11 1094 4306703 SGTC_2935 9038016 29.96 µM -9.54443463801017 2.01299560199115e-20 yes 3356 6.84259958436484e-22 1095 6463195