SGTCid condition conc unit UPS1|YLR193C.score UPS1|YLR193C.strain.pval UPS1|YLR193C.strain.significant UPS1|YLR193C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_871 0574-0004 149 µM 5.23751495842671 2.36999930305854e-08 yes 1 8.1376556617802e-08 18 9551173 SGTC_513 4245-1575 41.7 µM 4.5389539727722 1.05556934365519e-06 yes 2 2.82669866814456e-06 88 719745 SGTC_1119 parthenolide 318.541 nM 4.47838211148377 1.4329828973051e-06 yes 3 3.76054431103516e-06 27 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2375 9072683 200 µM 3.49418998107706 0.000122143000919012 yes 4 0.000237751256741287 28 16798029 SGTC_2391 6285546 200 µM 3.46850611769831 0.000135386583165954 yes 5 0.000261680305343729 29 846083 SGTC_1247 0448-0043 5.84 µM 3.4460618930517 0.000148050147485218 yes 6 0.000284410031751283 72 3089013 YGL099W LSG1 SGTC_149 3970-0822 46.1 µM 3.38207472930455 0.00019051076439819 yes 7 0.000359702856947308 136 3114250 YBL034C STU1 SGTC_3231 9132313 49.47 µM 3.28999136948638 0.000271894371678352 yes 8 0.000500952278674572 17 4905967 SGTC_690 glyoxal 20.3 µM 3.27362528113288 0.000289382389732884 yes 9 0.000530886556828057 125 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_3297 9117502 71.43 µM 3.21156702688173 0.000365656766440623 yes 10 0.000660065855284383 28 7453720 SGTC_1332 1480-0653 17.5 µM 3.15430279376567 0.000452221774391198 yes 11 0.000804410344459146 38 5749438 SGTC_2858 9025781 8.96 µM 3.15041288549023 0.000458742030557638 yes 12 0.000815199354031326 155 4894980 YPL153C RAD53 SGTC_704 1310-0270 142 µM 3.13364836553497 0.000487851785051663 yes 13 0.000863238064821588 66 5718033 SGTC_1834 st055981 52.8 µM 3.08468601217049 0.000582950174409607 yes 14 0.00101883573019992 69 471719 YDL150W RPC53 SGTC_540 1187-0821 17.3 µM 3.06286679427462 0.000630617480627595 yes 15 0.0010961381118273 41 847520 SGTC_2309 7664088 163.95 µM 3.0564152834536 0.000645386261604613 yes 16 0.00112000385145928 99 704922 SGTC_2027 5150920 200 µM 2.92619481376844 0.00102077345727619 no 17 0.00171567994239073 47 786715 SGTC_2035 5154463 94.595 µM 2.91581369853214 0.00105800945398293 no 18 0.00177381134139347 69 2769623 SGTC_212 3807-4682 38.772 µM 2.91471967269899 0.0010620053145873 no 19 0.00178004081298737 151 3125501 YBL034C STU1 SGTC_423 5-fluorouracil 457 µM 2.87073011422429 0.00123461145373779 no 20 0.00204762502178396 79 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2743 auranofin 4.32 µM 2.86000907247507 0.00128039803402071 no 21 0.00211814444319266 90 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_910 3454-3003 490 µM 2.8573470610523 0.00129200485672365 no 22 0.00213599225173101 76 820824 SGTC_375 3970-0961 9.27 µM 2.8148030286582 0.00149103967740104 no 23 0.00244035693123172 82 2898222 SGTC_282 k297-0036 65.7 µM 2.81424741485111 0.00149381472364004 no 24 0.00244457914215041 36 5061378 SGTC_3287 9117173 37.0625 µM 2.81136326057973 0.00150829566468268 no 25 0.00246660272699711 26 2789709 SGTC_3215 9129942 49.47 µM 2.79175433292266 0.00161019302890935 no 26 0.00262115704011428 48 17682944 SGTC_655 k060-0012 42 µM 2.77460787784759 0.00170439315801767 no 27 0.00276341503883567 68 5994525 SGTC_1618 st003135 44.5 µM 2.76899731118087 0.00173628944094885 no 28 0.00281145496326383 59 1270615 SGTC_236 1509-0011 5.31 µM 2.75241342306035 0.00183377126502133 no 29 0.0029578893108457 485 3107280 SGTC_3011 9081274 71.4286 µM 2.75170173073688 0.00183806392415286 no 30 0.00296432460042241 75 6625322 SGTC_266 formosanin C 406 nM 2.71665004813711 0.0020611334533362 no 31 0.0032973147574316 153 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_732 3970-1727 52.7 µM 2.6931014650504 0.00222450405641871 no 32 0.00353953608957726 57 1275699 SGTC_1365 1672-3266 55.4 µM 2.6607976348688 0.00246770887480194 no 33 0.00389778971238238 92 6415873 SGTC_1872 amphotericin b 148 nM 2.66074771894827 0.00246810259367203 no 34 0.0038983675547596 97 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1620 st003704 16.5 µM 2.64996911708481 0.00255446310922288 no 35 0.00402495644262149 72 2834414 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.63688522658576 0.00266295891347123 no 36 0.00418355680412687 73 756377 SGTC_2127 5253358 187.912 µM 2.63187917550027 0.00270555959828509 no 37 0.00424570274819374 97 20612 SGTC_1449 4112-4002 201 µM 2.61079769409489 0.00289179150140092 no 38 0.00451656566981118 81 2059539 SGTC_1644 st010134 20.9 µM 2.60515609078311 0.00294355146939298 no 39 0.00459162065674265 70 3818134 SGTC_1812 st052057 4.327 µM 2.59899301064218 0.00300104894490807 no 40 0.0046748838480622 113 3645418 SGTC_1756 st041558 35.5 µM 2.59518471682655 0.00303708169686662 no 41 0.00472700475774498 59 3955792 SGTC_728 3030-5151 22.5 µM 2.58623670068438 0.00312328287860161 no 42 0.00485151359062706 69 3125388 SGTC_163 TUB2.036 7.546 µM 2.57166628792605 0.00326836939166563 no 43 0.00506051986571227 260 15992207 YJR013W GPI14 SGTC_1874 staurosporine 7.6 µM 2.56659891361841 0.00332023157900519 no 44 0.00513506646123025 129 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1873 rapamycin 2 nM 2.53338294619168 0.00367889332019191 no 45 0.00564837315279992 190 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2740 felodipine 17.08 µM 2.52172201411248 0.00381282006382704 no 46 0.00583909777539432 76 3333 L-type calcium channel blocker SGTC_1079 idarubicin 2.36 µM 2.49499359546342 0.00413642286677087 no 47 0.00629797018069721 99 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1240 0356-0016 42.1 µM 2.47312236293879 0.00441927122311049 no 48 0.00669691374517743 134 4305613 SGTC_1875 nocodazole 6 µM 2.47251271029169 0.00442739726357214 no 49 0.00670834713064449 128 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2122 5258151 111.688 µM 2.4587439459459 0.00461451095366334 no 50 0.00697120091235233 126 2173356 SGTC_422 cantharidin 155 µM 2.44895186404439 0.00475184455885864 no 51 0.00716362969527191 190 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2151 5563267 85.4165 µM 2.44577731807822 0.00479714343876573 no 52 0.0072270121281738 135 5310824 SGTC_799 1310-0557 151 µM 2.44346872123616 0.00483032713957569 no 53 0.0072734152579485 130 5354492 SGTC_2077 5212015 200 µM 2.41906051326216 0.00519389007266123 no 54 0.00778032567514965 171 780900 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 2.41541429867597 0.00525024209630387 no 55 0.00785866037106145 107 688798 SGTC_1353 1498-1206 8.11 µM 2.4070834940908 0.00538103983895295 no 56 0.00804024650117006 191 6756808 SGTC_63 0099-0242 26.702 µM 2.37593414951082 0.00589613334062609 no 57 0.00875229320496136 231 3898502 YLR359W ADE13 SGTC_1004 4084-0029 199 µM 2.37301361981393 0.00594660084822558 no 58 0.00882180665659618 140 716894 YLR208W SEC13 SGTC_2057 5236571 38.335 µM 2.36822487265481 0.00603018088683157 no 59 0.00893683426567839 186 54684039 YBR257W POP4 SGTC_3202 9113761 49.47 µM 2.36632999803875 0.00606353939986985 no 60 0.00898271149392314 194 4798415 SGTC_2659 sanguinarine 24.21 µM 2.36521107848855 0.00608331424042214 no 61 0.00900989867010143 125 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1454 4239-0054 42.6 µM 2.34251071000141 0.0064970318485818 no 62 0.00957724211125774 173 1340767 SGTC_2567 aureobasidin a 60 nM 2.34233081861776 0.00650040743783867 no 63 0.00958186004424185 247 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2707 st078556 66.6 µM 2.32589649579309 0.00681541146631831 no 64 0.0100120365152807 106 17250899 SGTC_2845 9003024 42.97 µM 2.32233072122464 0.00688551244313441 no 65 0.0101075672805953 198 2990173 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 2.31923335871743 0.0069469207050489 no 66 0.0101911933081253 147 94937 An inhibitor of serotonin biosynthesis. SGTC_1877 wortmannin 25 µM 2.30346687415932 0.00726706110433677 no 67 0.0106262944425755 240 312145 A covalent inhibitor of PI 3-kinase. SGTC_1271 0832-2808 169 µM 2.29126654791656 0.00752364746452347 no 68 0.0109740010586711 146 3663794 SGTC_3152 9099253 49.47 µM 2.29100114678136 0.00752931672721381 no 69 0.0109816736677575 315 25236131 SGTC_625 k213-0058 121 µM 2.29007321604799 0.00754916794427336 no 70 0.011008536360005 320 3655420 SGTC_3240 9133527 49.47 µM 2.28296316836695 0.00770280897868421 no 71 0.0112162690024702 123 17617455 SGTC_159 3970-0959 50 µM 2.26752651511592 0.00804588567132752 no 72 0.0116790405120915 330 6615653 SGTC_645 0845-0943 5.41 µM 2.25466409917988 0.00834193642393365 no 73 0.0120772103594445 136 1885106 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 2.23985674406752 0.00869455976684323 no 74 0.0125501123077309 130 2724278 An inhibitor of dopamine biosynthesis. SGTC_549 1661-1316 519 µM 2.23628127488578 0.00878164054783366 no 75 0.0126666761170801 156 2857282 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 2.23164526584111 0.0088956886007965 no 76 0.0128192087026693 163 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1847 st056231 15 µM 2.23162721166959 0.00889613526722709 no 77 0.0128198058078988 218 5393180 SGTC_2768 sulfasalazine 50.2 µM 2.22846261724735 0.00897473268623118 no 78 0.0129248407572948 154 5384001 An antioxidant and salicylic acid derivative. SGTC_2263 7948595 193.29 µM 2.21197660587674 0.0093941032087249 no 79 0.0134841407041588 109 2971371 SGTC_32 0928-0142 34.1 µM 2.19972403566469 0.00971679183588122 no 80 0.0139132402081868 105 2244242 SGTC_1509 1326-1131 80 µM 2.19653855666404 0.0098022558922911 no 81 0.0140267092951946 132 768313 SGTC_518 1021-0119 62.6 µM 2.19272156424094 0.0099055271029075 no 82 0.014163723047168 210 1097762 SGTC_791 1348-1292 225 µM 2.1785535706071 0.0102972038339208 no 83 0.0146824242491233 243 5437054 SGTC_1641 st009299 47.1 µM 2.16858879247157 0.0105807087175685 no 84 0.0150569584052226 106 4046054 SGTC_3041 9091929 49.47 µM 2.16613575519553 0.0106515336381088 no 85 0.0151504073293541 182 25236887 SGTC_832 4083-0019 164 µM 2.15710343520986 0.0109158890069426 no 86 0.0154988030099009 361 1990758 SGTC_874 0599-0792 117 µM 2.15482939786234 0.010983337784778 no 87 0.0155875934294427 199 765305 SGTC_116 0155-0182 31.788 µM 2.15346541843582 0.0110239676347993 no 88 0.0156410595384177 321 771486 SGTC_2278 7948257 134.34 µM 2.1447424705693 0.0112869091178958 no 89 0.0159867215923576 163 1247028 SGTC_1445 4239-0156 97.7 µM 2.13715996051538 0.0115198852680261 no 90 0.016292491708028 208 4008346 SGTC_882 0843-0131 351 µM 2.13670132355516 0.0115341100939699 no 91 0.0163111461477841 185 5425421 SGTC_1317 1273-0028 910 nM 2.13387084928467 0.0116222365110268 no 92 0.0164266771467083 185 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2045 5106652 78.05 µM 2.1272926000646 0.0118293105433261 no 93 0.016697889612048 159 673349 SGTC_798 1287-0182 476 µM 2.12225765685828 0.0119899590408752 no 94 0.0169080535811506 219 1649755 SGTC_795 0685-0265 78 µM 2.10716523907337 0.0124828948918454 no 95 0.0175516294546899 204 302754 SGTC_1039 k821-0043 94 µM 2.09915862679748 0.0127514542322281 no 96 0.0179014598899128 195 15992768 SGTC_1305 1181-0477 144 µM 2.08946782725054 0.0130831792929674 no 97 0.0183328155659672 182 6252086 SGTC_2515 chrysin 20.77 µM 2.08107337632431 0.0133765321896001 no 98 0.0187135951617847 168 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2041 5107442 45.335 µM 2.07653481605737 0.0135374899883711 no 99 0.018922257262624 235 793005 SGTC_621 3584-0052 32.1 µM 2.07570630904946 0.0135670523241071 no 100 0.0189605610417009 198 2273927 SGTC_2890 9046729 58.44 µM 2.07415834856661 0.0136224351281063 no 101 0.0190323035358627 169 903329 SGTC_1740 st038286 13.222 µM 2.06106418190761 0.0140987723102412 no 102 0.0196484586916389 222 716786 SGTC_3232 9132874 49.47 µM 2.04065299568774 0.01486989982268 no 103 0.020642665275848 185 3784940 SGTC_2000 st075254 36.4 µM 2.03330672574452 0.0151561796777599 no 104 0.0210107720505047 158 17234175 SGTC_1073 triclabendazole 3.09 µM 2.03020661475999 0.0152784026390293 no 105 0.0211677708764299 254 50248 An antihelmetic and likely tubulin inhibitor. SGTC_183 3914-0051 30.55 µM 2.02675463475866 0.0154154933501652 no 106 0.0213437559970615 208 1596232 SGTC_2246 7293507 91.5585 µM 2.02630191595249 0.0154335505634354 no 107 0.0213669275246008 222 887656 SGTC_118 0083-0097 135.343 µM 2.02441414122591 0.0155090425035961 no 108 0.0214637789760651 470 5207356 SGTC_377 3970-0964 33.1 µM 2.01894577530934 0.0157295132603537 no 109 0.021746427878986 320 16481235 SGTC_314 1671-0008 2.74 µM 2.01706164798099 0.0158060967314244 no 110 0.0218445401522072 283 3913060 SGTC_1862 st057513 3.81 µM 2.00660384964647 0.0162370093844746 no 111 0.0223959305478323 177 5393163 SGTC_1204 4049-0315 18.3 µM 2.00609648062855 0.0162581689925117 no 112 0.0224229776424454 237 588402 SGTC_857 0438-0306 1.35 µM 2.00504790233215 0.0163019743613571 no 113 0.022478963113962 193 4686136 SGTC_3216 9129716 49.47 µM 1.99330286951726 0.016799581480547 no 114 0.0231141461925389 206 8056934 SGTC_2608 thymoquinone 42.66 µM 1.98028352045919 0.017366305070489 no 115 0.0238358397417493 195 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1892 st058411 7.36 µM 1.97767280979746 0.0174818918701186 no 116 0.0239828147783666 255 3934738 SGTC_130 0136-0219 337.655 µM 1.96927844351217 0.0178580061490157 no 117 0.0244605625985696 231 234244 SGTC_508 roscovitine 141 µM 1.96922793892688 0.0178602897606312 no 118 0.0244634609628353 170 160355 A CDKinase inhibitor. SGTC_1730 st033808 45.1 µM 1.96239404644762 0.018171596263487 no 119 0.0248583126862042 301 1045166 SGTC_2357 9067248 200 µM 1.9547606915099 0.0185247769202987 no 120 0.0253056614077601 193 9150235 SGTC_2738 aclarubicin 5.55 µM 1.95025870056581 0.0187358029597536 no 121 0.0255726462257006 151 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2866 9034245 58.44 µM 1.94954092108245 0.0187696364879408 no 122 0.0256154304432809 174 6462273 SGTC_3266 9136860 49.47 µM 1.94842587352628 0.0188222989083782 no 123 0.0256820132112291 251 4871271 YPR165W RHO1 SGTC_2156 5649887 115 µM 1.94799688231037 0.0188425931338942 no 124 0.0257076680998941 257 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1306 1185-0270 9.02 µM 1.93181361320338 0.0196218859677901 no 125 0.0266912576153693 255 1548076 SGTC_865 0488-0499 301 µM 1.92768414676571 0.0198250644299683 no 126 0.0269472125821681 223 9634651 SGTC_1126 isoteolin 1.0172 µM 1.91209146043543 0.0206084320302922 no 127 0.0279322319911874 262 133323 SGTC_3093 9117344 49.47 µM 1.90546228384916 0.0209493361972544 no 128 0.0283600028234895 230 24824913 SGTC_609 0986-0026 86.3 µM 1.89533557189282 0.0214793085497007 no 129 0.029023979181069 290 2848610 SGTC_1779 st039427 55 µM 1.8889561150979 0.0218189560326272 no 130 0.0294488546562634 318 1124498 SGTC_2843 9000894 45.46 µM 1.88256387115053 0.0221638229988712 no 131 0.029879748214078 141 2242070 SGTC_1273 0849-0096 14.1 µM 1.86989697800366 0.0228608128114822 no 132 0.0307490627768976 261 5286025 SGTC_1621 st003705 32.4 µM 1.86782353936164 0.0229766434326047 no 133 0.0308933356224853 287 24207032 SGTC_1510 1123-0200 71.5 µM 1.85673970598092 0.0236042471800684 no 134 0.0316740977683821 342 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_483 fpl-64176 144 µM 1.85476908544452 0.0237173264573163 no 135 0.0318146042245156 175 3423 SGTC_2296 7971656 126.45 µM 1.85265573950025 0.0238391015192972 no 136 0.0319658588672421 295 666570 SGTC_81 0411-0046 9.971 µM 1.84278277119421 0.0244149857581579 no 137 0.032680366639744 234 12925265 SGTC_1232 0279-0259 161 µM 1.84009009000473 0.0245740600837527 no 138 0.0328775059871717 268 1560000 SGTC_1286 0929-0070 131 µM 1.83092111635227 0.0251222691071341 no 139 0.0335561590136501 295 1420408 SGTC_2987 9018338 71.43 µM 1.82586382256555 0.0254290039253294 no 140 0.0339353883939047 294 5055682 SGTC_1501 4491-0275 38.4 µM 1.82134100211192 0.0257059729858146 no 141 0.0342775186882583 245 5104718 SGTC_1534 6-azauridine 81.6 µM 1.81179230757224 0.0262990161141426 no 142 0.0350091470812639 328 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_416 estradiol valerate 100 µM 1.80622328055087 0.0266501432942722 no 143 0.0354417349366731 282 13791 A steroid. SGTC_2407 paclitaxel 400 µM 1.79882315971043 0.0271227718541522 no 144 0.0360233292961625 333 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3300 9124615 50.48 µM 1.7884621530727 0.0277962390889671 no 145 0.0368507382464893 308 24824903 SGTC_1602 st001878 87.6 µM 1.78213711539332 0.0282141752767627 no 146 0.037363437278942 265 595405 YLR310C CDC25 SGTC_1912 st060209 90.8 µM 1.77845152693135 0.0284601089976937 no 147 0.0376648631873554 295 688787 SGTC_2967 9089538 49.85 µM 1.77470660477179 0.0287118262043634 no 148 0.0379731721016268 321 728216 SGTC_2806 7952793 58.44 µM 1.77399367413904 0.0287599554197741 no 149 0.0380320983379565 294 2972490 SGTC_504 lovastatin 124 µM 1.77112421399301 0.0289543485583226 no 150 0.0382700241200717 242 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2139 5578692 56.4705 µM 1.76025626143691 0.029700530162342 no 151 0.0391821832740051 254 650991 YMR113W FOL3 SGTC_315 k915-0449 187 µM 1.75730362402701 0.0299059893223464 no 152 0.0394330352105648 366 20970215 YNL149C PGA2 SGTC_620 0109-0052 432 µM 1.75228383534878 0.0302579962569374 no 153 0.0398625070824306 294 493037 SGTC_2130 NSC 7 2.4545 µM 1.74620156373881 0.0306891026895505 no 154 0.0403879666025424 325 21448 SGTC_869 0564-0080 44.1 µM 1.74415762978322 0.0308351119211783 no 155 0.0405658036291171 336 6843321 SGTC_2207 7258803 200 µM 1.73940106509812 0.0311771261516159 no 156 0.0409821205163085 247 3666799 SGTC_141 0443-0274 32.331 µM 1.7337844864901 0.0315850126760458 no 157 0.0414781646245851 455 1627241 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.72350021348814 0.0323433056286464 no 158 0.0423990533004357 336 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1276 0871-0068 94.2 µM 1.72078230448284 0.0325461966688904 no 159 0.0426451673216682 285 3414906 SGTC_1616 st002734 56.1 µM 1.71998812498784 0.0326056797239391 no 160 0.0427173000863326 353 4026101 SGTC_2639 lactacystin 53 µM 1.71013449615333 0.0333511895006117 no 161 0.0436205025561763 343 3870 A proteasome inhibitor. SGTC_3336 9143619 71.43 µM 1.69710936378738 0.0343581343600557 no 162 0.0448379931180864 348 45595730 SGTC_300 r073-0011 5.04 µM 1.68673444868653 0.0351779565019888 no 163 0.0458272124851901 373 2735780 SGTC_1491 4138-0063 26.5 µM 1.68601739935423 0.0352352054401477 no 164 0.045896224061956 271 23883227 SGTC_2628 lathosterol 100 µM 1.68488741664562 0.035325577920481 no 165 0.046005147394587 345 6710616 SGTC_2863 9028737 58.44 µM 1.68356481048424 0.0354315972128493 no 166 0.0461329021220035 259 6460917 SGTC_1766 st045414 44.774 µM 1.68043413261309 0.0356835903993679 no 167 0.0464364398568247 367 253960 SGTC_2420 aureobasidin a 50 nM 1.68030318594907 0.0356941624243084 no 168 0.0464491707573181 398 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_973 1325-0077 65.9 µM 1.67184645704043 0.0363823746615767 no 169 0.0472773016115086 357 2835149 SGTC_2015 5119600 184 µM 1.66732476960038 0.0367547843769322 no 170 0.0477249219704497 340 2828786 SGTC_309 k408-0051 1.48 µM 1.66685939414209 0.036793289375589 no 171 0.0477711833739214 431 3640463 SGTC_720 r052-1644 49.9 µM 1.66493298394681 0.0369530309165102 no 172 0.0479630633846325 297 1422863 YOR257W CDC31 SGTC_598 3937-0236 20.2 µM 1.66412148998424 0.0370204910232858 no 173 0.0480440766572855 386 1379313 SGTC_463 ikarugamyin 104 µM 1.65671030192054 0.0376412578593056 no 174 0.0487890295997515 227 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1793 st048256 72.231 µM 1.64454274547765 0.0386788306388401 no 175 0.0500320711585345 284 672022 SGTC_2218 6965428 192.983 µM 1.64387935599305 0.0387360636282953 no 176 0.05010056259922 325 675684 SGTC_2520 obtusaquinone 4.71 µM 1.64151000380255 0.0389410396033509 no 177 0.0503457960992018 337 5967872 SGTC_2252 omeprazole 400 µM 1.63848694007305 0.0392038505609049 no 178 0.050660078105567 237 4594 A proton pump inhibitor. SGTC_2107 5363541 170.161 µM 1.63560670934655 0.0394555854267589 no 179 0.0509609626378919 350 244052 SGTC_3170 9103054 49.47 µM 1.63488070836545 0.0395192456632826 no 180 0.0510370286752858 306 16432970 SGTC_470 aa-861 153 µM 1.63296080005867 0.0396879977248455 no 181 0.051238620687752 403 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1830 st055982 50.3 µM 1.63207219322208 0.0397663007326096 no 182 0.0513321393815351 378 455313 An antimicrobial agent. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.62341310692342 0.0405359229110035 no 183 0.0522505623555614 394 4174840 SGTC_3230 9131665 49.47 µM 1.62322529231845 0.0405527489661263 no 184 0.0522706264965182 183 15943720 SGTC_1933 st074711 15.9 µM 1.62240757879101 0.0406260728991456 no 185 0.0523580537435369 387 17250958 SGTC_3282 9108498 15.4605 µM 1.61845525273742 0.0409819942221085 no 186 0.0527822614026023 379 16459645 SGTC_2370 9071495 200 µM 1.61292397830819 0.0414843477609608 no 187 0.0533805125102443 361 21791103 SGTC_1371 2421-0008 32.7 µM 1.61060061827056 0.0416968394306719 no 188 0.0536333994934051 387 2827552 SGTC_2862 9027634 71.43 µM 1.60901551305965 0.0418423164821113 no 189 0.0538064747817367 352 5012562 SGTC_2439 5492030 7.2 µM 1.60873357213194 0.0418682353278628 no 190 0.0538373057731239 337 5722370 SGTC_23 0213-0011 39.996 µM 1.60833281402389 0.0419050994143407 no 191 0.0538811538115576 353 627608 SGTC_451 chloral hydrate 100 µM 1.60272108077406 0.0424240652447544 no 192 0.0544981235988311 453 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_830 4076-0286 57.8 µM 1.60093985500016 0.0425898734001881 no 193 0.0546951205580495 557 6866659 SGTC_800 3448-7362 155 µM 1.59538395385717 0.0431104216708903 no 194 0.055313201016188 665 15991913 SGTC_2803 7707263 71.43 µM 1.59374196819392 0.0432652440932797 no 195 0.055496920064704 338 2199229 SGTC_2079 5212404 121 µM 1.59364967449451 0.0432739597544169 no 196 0.0555072609362985 343 758462 SGTC_2870 9038528 12.99 µM 1.59268421794135 0.043365216670933 no 197 0.0556155248800058 344 6463316 SGTC_1739 st037196 92.5 µM 1.59072475336397 0.0435509069233655 no 198 0.0558357668195724 389 612214 SGTC_1767 st044992 70.3 µM 1.5906503175254 0.0435579735288131 no 199 0.0558441468837801 409 9600693 SGTC_683 panaxydol 45 µM 1.57801255903779 0.0447712270379521 no 200 0.0572813622974177 402 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_724 3910-0327 137 µM 1.57770132410869 0.0448014461819473 no 201 0.0573171209844967 390 2885483 SGTC_3194 9111903 49.47 µM 1.57654761883233 0.0449136077146641 no 202 0.0574498268008697 386 17087251 SGTC_1795 st049545 62.3 µM 1.5745175418996 0.045111517559005 no 203 0.0576839246612416 363 5291882 SGTC_2751 anetholtrithion 17.25 µM 1.56520858251793 0.0460280414011821 no 204 0.0587670048931113 407 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2123 5259487 200 µM 1.5613555413052 0.0464117476650779 no 205 0.0592199427787221 393 2173474 SGTC_2329 6138490 200 µM 1.56035637485636 0.046511668097907 no 206 0.0593378440094023 358 720019 SGTC_761 k216-0224 480 µM 1.55964625000123 0.0465827881807708 no 207 0.0594217502721768 405 1340404 SGTC_527 4476-4215 268 µM 1.55914125437519 0.0466334173372638 no 208 0.0594814756376685 394 4418754 SGTC_371 0195-0006 7.36 µM 1.55765142151594 0.0467830402750786 no 209 0.0596579509941871 328 3928593 SGTC_3228 9131799 49.47 µM 1.53946494817718 0.0486407111688035 no 210 0.0618454143806195 371 17015818 SGTC_2052 5265182 7.135 µM 1.53741232649915 0.0488540305663771 no 211 0.0620961848631879 415 1239884 SGTC_2382 9035899 200 µM 1.53636444627289 0.0489632197599125 no 212 0.0622245107659556 407 6462679 SGTC_441 propafenone 146 µM 1.53330975474693 0.0492826317630667 no 213 0.0625997761341998 339 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1744 st037937 38.9 µM 1.53213013721526 0.0494064221880588 no 214 0.0627451620750969 396 1016152 SGTC_628 1636-0253 16 µM 1.53045468523514 0.0495826725707275 no 215 0.062952110922037 428 4456143 SGTC_3034 9090421 49.47 µM 1.52379520990575 0.050288186898547 no 216 0.063779938262519 355 17173761 SGTC_189 3970-0742 2.116 µM 1.51832130382486 0.0508740717195819 no 217 0.0644667098292826 365 2891807 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.50687888953583 0.0521163277668518 no 218 0.0659208517329387 380 2374 Ca(2+)-ATPase inhibitor. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.49600171007608 0.0533194419182107 no 219 0.067326604772232 416 688662 SGTC_1091 telmisartan 47.6 µM 1.49566553449797 0.0533569737420568 no 220 0.0673704180070793 437 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1948 st076329 66.6 µM 1.49004245723427 0.0539878630967756 no 221 0.0681065363573527 393 24208413 SGTC_2374 9071832 200 µM 1.48900562302453 0.0541048344599361 no 222 0.068242944018265 388 17381698 SGTC_852 0418-0143 439 µM 1.48149801046384 0.054957807223379 no 223 0.0692369573435598 517 5369229 SGTC_114 0364-0001 490.298 µM 1.47929901653796 0.0552096464864772 no 224 0.069530207803461 445 4003655 SGTC_2629 bisabolol 100 µM 1.47228606538493 0.0560188960112826 no 225 0.0704718223005269 457 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1758 st042942 75.2445 µM 1.47218986288681 0.0560300618635913 no 226 0.0704848070361021 420 669317 SGTC_778 3456-2434 196 µM 1.46764932640601 0.0565590637833868 no 227 0.0710997509754353 536 5539063 SGTC_784 4579-0127 173 µM 1.46574824367532 0.0567817177180794 no 228 0.0713584428909398 462 1948547 SGTC_1665 st014639 11.4 µM 1.4655137779206 0.0568092259971811 no 229 0.0713903980576918 496 981133 YIL048W NEO1 SGTC_3284 9108171 64.8615 µM 1.46497621817483 0.0568723338595272 no 230 0.0714637031396325 388 8687505 SGTC_699 0375-0592 111 µM 1.46439638418574 0.0569404664659079 no 231 0.0715428377506443 421 762578 SGTC_406 estrone 100 µM 1.46424974679485 0.0569577070717168 no 232 0.0715628611840615 450 5870 A steroid. SGTC_803 4488-1585 147 µM 1.46314823217416 0.0570873469466108 no 233 0.0717134112357456 394 747204 SGTC_3180 9109287 49.47 µM 1.46093087849112 0.0573490169017229 no 234 0.0720172057698734 383 18891271 SGTC_2847 9005661 71.43 µM 1.45614859843078 0.0579165860431012 no 235 0.0726757727080703 292 2991449 SGTC_994 3910-0338 138 µM 1.45322907679485 0.0582652444539887 no 236 0.0730800807690556 475 3479481 SGTC_2973 9094665 17.96 µM 1.45097945206155 0.0585350247071535 no 237 0.0733927910053958 503 25237061 YIL048W NEO1 SGTC_634 1611-4317 11.2 µM 1.43971749381073 0.0599003574807861 no 238 0.0749736709793236 490 2843522 SGTC_1846 st056244 14.8 µM 1.4382095325066 0.0600850520526866 no 239 0.0751873056607178 482 5393182 SGTC_325 2810-4341 181 µM 1.42910003319767 0.061210279332897 no 240 0.0764877419909497 429 774970 SGTC_2466 5983409 37.09 µM 1.4276139016954 0.0613954021720003 no 241 0.0767015100230099 452 2879657 SGTC_2462 5162487 171.77 µM 1.42637764456159 0.0615497319193615 no 242 0.0768796815494478 454 2259986 SGTC_2380 9035439 200 µM 1.4253969889121 0.06167236867074 no 243 0.0770212389887583 522 6462575 SGTC_1179 1021-1431 9.29 µM 1.42179161199052 0.0621248829349076 no 244 0.077543377686025 544 2840958 SGTC_3195 9113082 49.47 µM 1.41990913365361 0.0623621817072714 no 245 0.0778170682605606 428 17018038 SGTC_842 0271-0008 11.1 µM 1.41659809140624 0.0627812746354595 no 246 0.0783002334349984 510 1221709 SGTC_70 0141-0289 43.283 µM 1.4150607106036 0.0629766121646894 no 247 0.0785253482563794 703 352408 SGTC_2025 5147754 141 µM 1.41249680488255 0.0633034313255118 no 248 0.0789018654072111 433 315777 YLR208W SEC13 SGTC_2421 5690543 90.72 µM 1.41149341368228 0.063431691764929 no 249 0.0790495881498466 472 3397993 SGTC_2960 9079389 5.97 µM 1.41088801372459 0.0635091759781871 no 250 0.0791388184967293 484 16457355 SGTC_1831 st055328 12 µM 1.41084828638298 0.0635142631941133 no 251 0.0791446766045538 463 1103068 SGTC_195 4234-0266 16.654 µM 1.41036439692974 0.063576252278617 no 252 0.079216056255583 532 2303354 SGTC_571 k831-0106 44.2 µM 1.40883057062203 0.0637730556039597 no 253 0.0794426366394389 444 4783639 SGTC_2747 doxorubicin 7.63 µM 1.40744433767305 0.0639513288000263 no 254 0.0796478358444533 301 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2110 5483698 200 µM 1.40335468555306 0.0644795273264894 no 255 0.080255549276461 457 2848765 YHR062C RPP1 SGTC_2142 5622915 118.518 µM 1.40254965537027 0.0645838990357145 no 256 0.0803755867372737 417 5322196 SGTC_190 3970-0790 3.722 µM 1.40099827826382 0.0647854042730093 no 257 0.0806072939841165 432 2832352 SGTC_530 4358-1714 28 µM 1.39961713520302 0.064965208616167 no 258 0.080813999974356 550 1564641 SGTC_397 arbidol 50 µM 1.39906566752706 0.0650371096477508 no 259 0.0808966459826002 507 131410 A RNA synthesis inhibitor. SGTC_3086 9117350 49.47 µM 1.38998345586353 0.0662301641803416 no 260 0.0822669506160343 365 2679265 SGTC_2705 st078069 42.8 µM 1.38700027934099 0.0666257158014259 no 261 0.0827208388271113 463 1530061 SGTC_2126 5251174 33.877 µM 1.38181433661853 0.0673176901216233 no 262 0.0835143579333376 592 790722 SGTC_2670 beta-carotene 100 µM 1.37857463809948 0.067752783049058 no 263 0.0840129703161051 401 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1031 k035-0009 16 µM 1.37489543288217 0.0682495325875199 no 264 0.0845819327024653 553 5180959 SGTC_69 0096-0274 206.684 µM 1.37462809775091 0.0682857362109697 no 265 0.0846233865026423 570 6741392 SGTC_324 1315-0088 19.6 µM 1.37294255508453 0.0685143407264105 no 266 0.0848851028721982 422 6787421 SGTC_731 3966-0296 387 µM 1.37129314227052 0.068738616148757 no 267 0.0851417963051036 484 660956 SGTC_1495 4469-0029 237 µM 1.37051362051976 0.0688448067686838 no 268 0.0852633132892331 636 793680 SGTC_455 paf C-16 10 µM 1.36624032767271 0.0694291859914539 no 269 0.0859317717967636 475 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1024 4507-0395 26 µM 1.36590723839331 0.0694748964627651 no 270 0.0859840402625616 504 4201836 SGTC_911 3456-4043 236 µM 1.36217963130573 0.0699880252194023 no 271 0.0865706011597741 523 914281 SGTC_2879 9041815 71.43 µM 1.35772945144749 0.0706044335966306 no 272 0.0872747739610362 373 4942971 SGTC_951 1171-0579 82.7 µM 1.35767631024363 0.0706118194808973 no 273 0.0872832085037803 598 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2638 epoxomicin 18 µM 1.3567567241195 0.0707397231613411 no 274 0.0874292611084769 546 9915668 A protesome inhibitor. SGTC_661 1304-0007 33.6 µM 1.35492450144544 0.0709950945375604 no 275 0.0877208062301783 495 3117130 SGTC_3292 9120825 59.784 µM 1.35366015885014 0.071171728452988 no 276 0.0879224122191941 503 24824900 SGTC_797 k781-0471 270 µM 1.35307147877479 0.0712540845465475 no 277 0.088016398124675 508 23738129 SGTC_3226 9131256 49.47 µM 1.35216830375297 0.0713805805537924 no 278 0.088160740425396 352 17178073 SGTC_3212 9128307 49.47 µM 1.35060095172029 0.0716005082196251 no 279 0.0884116478930429 457 27243542 SGTC_2362 9071156 126 µM 1.34907478755226 0.0718151557030403 no 280 0.0886564727771176 501 653133 SGTC_861 0443-0273 110 µM 1.34450806723155 0.0724603906045981 no 281 0.0893920747477567 521 6149169 SGTC_2176 5809774 33.9695 µM 1.33598591178946 0.0736763561894872 no 282 0.0907769390732846 534 2870539 SGTC_2919 7978188 46.38 µM 1.33076370913204 0.0744291463141647 no 283 0.0916333863121652 543 2980291 SGTC_1524 corynanthine 62.1 µM 1.32687640885419 0.0749933098461018 no 284 0.0922747846873628 499 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3342 9147791 14.508 µM 1.32281425138172 0.0755863292355689 no 285 0.0929485783464728 526 1838168 SGTC_1314 1222-0010 41.1 µM 1.32120918734593 0.0758216289511241 no 286 0.093215811894145 515 3526027 SGTC_1722 st034304 3.6505 µM 1.32120730482784 0.075821905252303 no 287 0.0932161256551046 552 4036148 YLR033W RSC58 SGTC_1419 3993-2473 62.6 µM 1.3199351249249 0.076008801217797 no 288 0.0934283395103144 539 704026 SGTC_2451 5856223 45.7 µM 1.31937774417302 0.0760907964480073 no 289 0.0935214292067593 518 2179896 SGTC_2469 5655019 90.81 µM 1.31009812657206 0.0774658149642407 no 290 0.0950813210701854 565 2788239 SGTC_730 1436-0052 41.2 µM 1.30944320054729 0.0775635677226461 no 291 0.0951921329707107 488 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1635 st007035 42.4 µM 1.30934791910722 0.0775777970131162 no 292 0.0952082622811332 736 3716403 SGTC_1319 1306-0155 43.7 µM 1.30800399606465 0.0777787091118539 no 293 0.0954359769513657 601 3122360 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.30609230132946 0.0780651813506981 no 294 0.0957605853623847 536 1609 A potent and irreversible inhibitor of serine proteases. SGTC_552 k242-0005 476 µM 1.30342621693495 0.0784660364329739 no 295 0.0962146454172666 530 4088318 SGTC_198 3454-2873 16.191 µM 1.30162894831914 0.0787371412958313 no 296 0.0965216294895873 535 710957 SGTC_1849 st056239 19.2 µM 1.3001877211045 0.0789550522307197 no 297 0.0967683190093856 566 5393181 SGTC_3338 9144300 39.5675 µM 1.29969599930017 0.0790295040970303 no 298 0.0968525910523018 563 4901274 SGTC_2164 5685496 200 µM 1.29765207962584 0.0793395450244095 no 299 0.0972034587097975 579 759046 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.29256811836293 0.0801147203762275 no 300 0.0980802360962204 536 7104 SGTC_447 ml7 120 µM 1.29191468971161 0.0802147654962528 no 301 0.0981933449772068 547 4216 Selective myosin light chain kinase inhibitor. SGTC_2172 5754775 163.918 µM 1.29087302912947 0.0803744472167191 no 302 0.0983738545622776 518 2263357 SGTC_283 0987-0079 11.7 µM 1.28472660841916 0.0813215583447273 no 303 0.0994439183171346 597 411556 SGTC_1521 st012942 49.4 µM 1.28218009872378 0.0817164112504267 no 304 0.0998897378966474 606 24207259 SGTC_1132 3456-3614 2.5 µM 1.27967183927398 0.0821067443667568 no 305 0.100330286295124 662 3125502 SGTC_1763 st044482 94.5 µM 1.27747891322928 0.0824491549514728 no 306 0.100716610189458 570 88505 SGTC_1885 st057546 99.9 µM 1.27664854377182 0.0825790917744107 no 307 0.10086317772751 586 702008 SGTC_2905 7799065 20.05 µM 1.27363983391302 0.0830511880922767 no 308 0.101395544140912 525 1296806 SGTC_2292 7671323 168.05 µM 1.2712904799499 0.0834212340809905 no 309 0.10181266394538 568 937504 SGTC_862 0452-0056 10.2 µM 1.27091852850414 0.0834799334884943 no 310 0.101878817026259 552 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2661 dactinomycin 12.96 µM 1.26902632390766 0.0837790319106539 no 311 0.102215837761714 598 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_593 1203-0218 61.7 µM 1.26794280202501 0.0839506649147773 no 312 0.102409188719248 583 3666956 SGTC_1507 4075-3230 155 µM 1.26678681875921 0.0841340669796914 no 313 0.102615763254419 501 659771 SGTC_1646 st011709 75.6 µM 1.26461738936911 0.0844790685709509 no 314 0.103004258190359 527 5757843 SGTC_2739 tacrine 100.86 µM 1.262523428444 0.0848130740907266 no 315 0.103380250698303 535 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1987 st072290 61.9 µM 1.26215058622028 0.0848726494695389 no 316 0.103447302766017 595 54697379 SGTC_2020 4017018 200 µM 1.26004539060739 0.0852096213946879 no 317 0.103826494198765 568 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2796 7949634 45.45 µM 1.25844716932876 0.0854661122265381 no 318 0.10411504106517 548 2971588 SGTC_2124 5246320 200 µM 1.25793393987333 0.0855486004850171 no 319 0.10420782400307 566 579342 SGTC_922 1866-0035 480 µM 1.25674499644238 0.0857399211616276 no 320 0.104422994462913 671 3156169 SGTC_193 1273-0060 1.558 µM 1.25414400209917 0.086159580716922 no 321 0.104894834618315 490 2847393 YHR072W ERG7 SGTC_2898 9056270 58.44 µM 1.25179489180224 0.0865399186694219 no 322 0.105322305989756 507 19154699 SGTC_2959 9079155 11 µM 1.24803915783883 0.0871506044718917 no 323 0.106008358740473 510 16189457 SGTC_2801 7907800 81.82 µM 1.24762710039773 0.0872178008072444 no 324 0.106083824608239 617 6620925 SGTC_2104 5389443 200 µM 1.24641289932938 0.0874160317917203 no 325 0.106306423985982 644 2244536 SGTC_1700 st030840 7.9285 µM 1.24634917853686 0.0874264441552565 no 326 0.106318115222463 635 5499307 SGTC_769 0302-0231 76 µM 1.24607855139631 0.0874706765844329 no 327 0.106367779155599 683 571869 YER009W NTF2 SGTC_2834 9001755 58.44 µM 1.24247923824675 0.0880605525513696 no 328 0.10702989801989 522 2989575 SGTC_2691 st077356 60.2 µM 1.24247877774998 0.0880606282094907 no 329 0.107029982921264 604 2839272 SGTC_2476 5806916 10.51 µM 1.23963899704794 0.0885281171689545 no 330 0.107554474922735 561 2870194 SGTC_753 1322-0200 289 µM 1.23939893649672 0.0885677208890445 no 331 0.107598897552629 590 5403907 SGTC_1920 st075728 45.7 µM 1.23831386017016 0.0887468947951438 no 332 0.107799853258653 580 3400306 SGTC_902 1120-0002 2.07 µM 1.23626622692439 0.0890857465947067 no 333 0.108179810272369 613 3280475 SGTC_2474 5321570 43.32 µM 1.2357093765877 0.0891780630825988 no 334 0.108283305454177 559 2841384 SGTC_1972 st070201 17.4 µM 1.23498568991448 0.0892981445993077 no 335 0.108417914987429 601 2829099 SGTC_1627 st003713 25.6 µM 1.23497166973329 0.0893004721588614 no 336 0.108420524003333 671 16195070 YER133W GLC7 SGTC_2716 st080858 38.6235 µM 1.23417842483157 0.0894322361956131 no 337 0.108568212560081 593 5296050 SGTC_1275 0867-0008 21.1 µM 1.23214167182479 0.0897712186828702 no 338 0.108948083612674 594 3422836 SGTC_2529 gangaleoidin 93.61 µM 1.23198534754458 0.0897972755829261 no 339 0.108977278797438 589 4565183 SGTC_2748 diazoxide 86.69 µM 1.23157825905863 0.0898651574768603 no 340 0.10905333319464 537 3019 A potassium channel activatior. SGTC_535 2293-4129 48.2 µM 1.23022898888529 0.0900904206076117 no 341 0.10930568363379 679 396118 YIL048W NEO1 SGTC_90 0870-0863 4.608 µM 1.22643739661102 0.0907256794151846 no 342 0.110017060179916 638 1738164 SGTC_654 1124-0271 80.9 µM 1.2257198435109 0.0908462743675907 no 343 0.110152060080002 625 5403748 SGTC_1836 st055642 81 µM 1.21970576531508 0.0918617046395653 no 344 0.111288217629434 607 8571 SGTC_3328 9140624 29.0385 µM 1.21615904655371 0.0924644678713237 no 345 0.111962170517801 635 4904392 SGTC_3157 9099274 49.47 µM 1.21359365638727 0.0929022751550087 no 346 0.112451465322458 562 17217662 SGTC_1254 0550-0035 264 µM 1.2112525978908 0.0933031339174511 no 347 0.112899304912116 652 15121435 SGTC_899 1083-0020 478 µM 1.21060732388355 0.0934138483280593 no 348 0.113022967999907 617 767123 SGTC_2381 9035592 200 µM 1.20826375446427 0.0938167680528117 no 349 0.113472912773534 538 4749657 SGTC_335 4077-0256 27.6 µM 1.20781424864012 0.0938941960451644 no 350 0.113559359743919 694 3121989 SGTC_1664 st014217 9.02 µM 1.20732089055463 0.0939792319275941 no 351 0.113654294227197 659 3982782 SGTC_1810 st050138 53 µM 1.20597310258872 0.0942118282034636 no 352 0.113913930836777 570 3444541 SGTC_1255 0566-0045 221 µM 1.20231423342094 0.0948454030336968 no 353 0.114620902185048 627 2788469 SGTC_1988 st071872 53.4 µM 1.2001229178611 0.0952263543693301 no 354 0.115045803047498 611 16414116 SGTC_2727 riluzole 51.77 µM 1.19933117631094 0.0953642721486602 no 355 0.115199598578204 573 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1973 st070275 50.2 µM 1.1986199377837 0.0954882919986342 no 356 0.115337881001259 575 17118334 SGTC_2097 5376186 200 µM 1.19730245496308 0.0957183372140837 no 357 0.115594343955227 628 742755 SGTC_474 dl-dihydrosphingosine 5 µM 1.196439573288 0.0958692254993634 no 358 0.115762533055093 627 3058739 A sphingolipid protein kinase C inhibitor. SGTC_12 0849-0099 9.267 µM 1.19508464778457 0.0961065082228082 no 359 0.116026979760717 605 6071388 SGTC_2791 5663188 71.43 µM 1.19506669147614 0.0961096557362555 no 360 0.116030487248452 580 54690634 SGTC_1178 0988-0033 191 µM 1.19453138176974 0.0962035235582984 no 361 0.116135086309272 647 5392207 SGTC_652 0437-0092 114 µM 1.1903153237222 0.0969451758349965 no 362 0.1169612400737 595 3091274 SGTC_2708 st078559 56 µM 1.19016804699394 0.0969711591407062 no 363 0.116990174646033 513 17250902 SGTC_3017 9080681 49.47 µM 1.18960041191813 0.0970713520176503 no 364 0.117101741943405 613 16451914 SGTC_84 0443-0269 128.823 µM 1.18773124363514 0.0974018146565105 no 365 0.11746965518149 654 6150058 SGTC_2197 6588183 93.1375 µM 1.18764580991233 0.0974169387478284 no 366 0.117486490859946 577 884136 SGTC_2196 6573537 42.6665 µM 1.18451559575236 0.0979722601572616 no 367 0.118104513208163 613 2903087 SGTC_1080 nisoldipine 24.4 µM 1.1812403681489 0.0985557877579288 no 368 0.118753624463645 654 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3168 9103419 49.47 µM 1.18066420468155 0.0986587019587251 no 369 0.118868073398391 527 16649256 SGTC_2859 9028643 45.46 µM 1.17890404459184 0.0989735885660898 no 370 0.119218193509768 589 17151580 SGTC_2221 6807166 181.081 µM 1.17779871979475 0.0991717028298074 no 371 0.119438429576438 550 674925 SGTC_780 0109-0199 192 µM 1.17481914577196 0.0997071947179084 no 372 0.120033539348845 688 610414 SGTC_1663 st014140 55.4 µM 1.17372989361498 0.0999034825241548 no 373 0.12025161626064 740 4207120 SGTC_1148 3909-7663 27.7 µM 1.17273770143515 0.100082525204835 no 374 0.120450503798501 658 4084526 SGTC_2572 astragaloside iv 100 µM 1.17030511288759 0.100522480818279 no 375 0.120939102533693 629 45006101 An anti-inflammatory agent. SGTC_589 1227-0070 34.1 µM 1.16967525949686 0.100636625117469 no 376 0.121065839021813 652 2841384 SGTC_1355 1499-0035 1.68 µM 1.16927952426735 0.100708390024619 no 377 0.121145515001751 615 1548538 SGTC_597 k018-0003 82.8 µM 1.1691333013447 0.100734916373418 no 378 0.121174964355738 712 6786234 SGTC_2891 9063876 19.48 µM 1.16869127921136 0.100815134738147 no 379 0.121264018402716 577 6472478 SGTC_1680 diphenhydramine 100 µM 1.16830803883328 0.100884723057771 no 380 0.121341266953366 631 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2103 5378138 10 µM 1.16669197220474 0.101178551685766 no 381 0.12166739296441 721 244142 SGTC_469 w7 172 µM 1.16629293409707 0.101251199566716 no 382 0.121748014521208 600 45115570 A P450 inhibitor. SGTC_836 0330-0104 1.35 µM 1.16556025808224 0.101384687677798 no 383 0.121896141914115 651 46494820 SGTC_484 loperamide 105 µM 1.15886614099807 0.102610246291315 no 384 0.123255376116436 542 3955 An opioid-receptor agonist. SGTC_2754 granisetron 64.02 µM 1.15568179515847 0.103197001371485 no 385 0.123905668609221 658 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_884 0851-0618 334 µM 1.15465314399361 0.103387062715446 no 386 0.124116247258579 691 9642473 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.15302482188354 0.103688443051997 no 387 0.124450098225785 717 16486 A toxic proline analog. SGTC_338 4055-0136 114 µM 1.15059707747607 0.104138968454488 no 388 0.124949017941773 656 2900563 SGTC_270 tamoxifen 5.46 µM 1.1483760540439 0.104552373383711 no 389 0.125406677334996 730 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_3190 9110366 49.47 µM 1.148121695543 0.104599793566962 no 390 0.125459164487276 558 17123768 SGTC_2555 cholic acid 100 µM 1.14643413909881 0.104914800170463 no 391 0.125807781894022 658 6708657 Influences liver metabolism. SGTC_2886 9058944 51.95 µM 1.1385294252424 0.106399472636519 no 392 0.127449739549744 496 4949929 SGTC_2563 tomatine 8.54 µM 1.13815179938398 0.106470776529387 no 393 0.127528550796076 733 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3183 9108214 49.47 µM 1.13749687388742 0.106594522356098 no 394 0.127665315347557 553 4974831 SGTC_2558 carylophyllene oxide 100 µM 1.13678450618276 0.106729239520281 no 395 0.127814190971058 716 6708694 An oxygenated terpenoid and antifungal agent. SGTC_570 0987-0065 62.6 µM 1.13513375757302 0.107041887773594 no 396 0.128159639650425 573 3104428 SGTC_1451 4152-0210 104 µM 1.13461713292818 0.107139870961383 no 397 0.128267885704826 692 659563 SGTC_2688 kanamycin b 96.69 µM 1.12581686160899 0.108818877577826 no 398 0.130121522758712 1107 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2438 5259590 200 µM 1.12372303647145 0.109221130393215 no 399 0.130565270245683 720 1201127 SGTC_933 2914-0560 114 µM 1.12159564195131 0.109630925421048 no 400 0.131017202730997 745 463887 SGTC_767 0929-0023 86 µM 1.11729227886521 0.110463244734877 no 401 0.131934687868531 790 1204563 SGTC_2918 7977171 22.06 µM 1.11416637237685 0.111070664530843 no 402 0.13260390943701 676 2236483 SGTC_1886 st057356 49.9 µM 1.11399214458557 0.111104590360634 no 403 0.132641278335168 653 24207747 SGTC_2255 7941087 197.44 µM 1.11095385442075 0.111697403009245 no 404 0.133294106313212 783 935561 SGTC_221 trifluoperazine 10.304 µM 1.11063576431699 0.111759597410157 no 405 0.133362580963044 831 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2526 patulin 37.61 µM 1.10970159524417 0.111942393512589 no 406 0.133563817631109 749 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3270 9137563 49.47 µM 1.10577000796058 0.112714060794903 no 407 0.134413039789077 642 17015724 SGTC_747 3448-8087 38.7 µM 1.10280529387146 0.113298463139991 no 408 0.135055864333884 720 5168703 SGTC_1142 3253-1408 9.78 µM 1.10186397105572 0.113484467319638 no 409 0.135260407041029 696 256655 SGTC_920 mycophenolic acid 780.421 nM 1.09974485579128 0.113903998416385 no 410 0.135721652467862 694 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_179 1273-0063 6.77 µM 1.09921422739996 0.11400922217615 no 411 0.135837317202332 643 3108139 SGTC_1222 0366-0074 1.18 µM 1.09819488745778 0.114211551830656 no 412 0.136059699109144 752 286520 SGTC_2215 7188065 200 µM 1.09732353604916 0.114384709734903 no 413 0.136249992906454 675 940217 SGTC_1698 5-fluorocytosine 1.055 µM 1.09689191582134 0.114470551957546 no 414 0.136344321549422 713 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1980 st071811 45.7 µM 1.09640697600559 0.114567053271183 no 415 0.136450356234379 699 4974850 SGTC_594 1487-1584 10.8 µM 1.0933290477248 0.115180900275905 no 416 0.137124676774773 700 5013332 SGTC_2496 diffractaic acid 79.83 µM 1.09158247217873 0.115530266904485 no 417 0.137508331891947 752 94870 An apoptosis inducer which activates caspases. SGTC_1974 st069448 26.9 µM 1.09021514924024 0.115804296776384 no 418 0.137809190803253 688 6323587 YNR016C ACC1 SGTC_400 oxethazaine 37.5 µM 1.0885596893623 0.116136690501335 no 419 0.138174050590239 686 4621 A local anesthetic. SGTC_1805 st050013 60.3 µM 1.08802864718666 0.116243459822243 no 420 0.13829123054353 679 4037144 SGTC_3162 9099653 49.47 µM 1.08583752211066 0.116684735654328 no 421 0.138775441252971 656 25237511 SGTC_2080 5212524 12.4 µM 1.08509960749946 0.116833613029031 no 422 0.138938770581542 694 260183 SGTC_1941 st076221 61.8 µM 1.08369264569678 0.117117846494434 no 423 0.139250548741863 759 2828568 SGTC_1201 1889-3372 45.9 µM 1.08327432974844 0.11720244880356 no 424 0.139343337940429 701 5392199 SGTC_1913 st060213 96.1 µM 1.08163487283066 0.117534438063937 no 425 0.139707401265463 756 688959 SGTC_187 1488-2104 32.728 µM 1.08130827866483 0.117600652676108 no 426 0.1397800030426 745 2852859 SGTC_919 tnp00227 403.569 nM 1.08120395822781 0.117621808455847 no 427 0.139803198845607 760 1269246 A methoxyflavone. YNL221C POP1 SGTC_2187 6125751 200 µM 1.08036580111606 0.117791881242179 no 428 0.139989659278547 732 874498 SGTC_1832 st054113 55 µM 1.07643011976744 0.118592808165793 no 429 0.14086746894395 694 1251267 SGTC_2514 salinomycin 42.74 µM 1.07598254879199 0.118684133767523 no 430 0.140967530600416 825 23682228 A polyether potassium ionophore. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.07455645837184 0.118975454863062 no 431 0.141286677416229 660 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2899 9053889 58.44 µM 1.06979722664179 0.119951321717686 no 432 0.142355295465642 717 6470052 SGTC_749 1000-0129 128 µM 1.06871986074077 0.120173013513866 no 433 0.142597959743994 776 708470 SGTC_3277 9138724 49.47 µM 1.06837621110701 0.12024378769888 no 434 0.142675421678403 638 15943418 SGTC_1293 1000-1278 195 µM 1.06722060182469 0.120481999289893 no 435 0.142936115796102 761 678847 SGTC_438 sphingosine 6.67 µM 1.06699486216928 0.12052857092207 no 436 0.142987078006185 619 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1023 4482-3888 16 µM 1.06666973982876 0.120595668155021 no 437 0.143060498083568 738 3303168 SGTC_2839 9003951 25.97 µM 1.06633304305417 0.120665181781978 no 438 0.143136558775916 708 2990634 SGTC_26 0302-0163 425.158 µM 1.06540714827135 0.120856485279496 no 439 0.143345861688244 742 3100915 SGTC_2358 9037157 4 µM 1.06241724181727 0.121475701153609 no 440 0.144023154922023 742 2388925 SGTC_186 3455-3465 67.277 µM 1.05818672604314 0.122355654914151 no 441 0.144985160845306 663 755278 SGTC_1773 st048542 73.5835 µM 1.05497602579247 0.123026464902384 no 442 0.145718144757512 727 3237138 SGTC_1219 1469-0211 33.1 µM 1.04763504339054 0.124569887030485 no 443 0.147403392726313 736 6822282 SGTC_3346 9158254 43.5805 µM 1.04722088353946 0.124657364632625 no 444 0.147498857833524 754 17639500 SGTC_1169 aniline yellow 25.8 µM 1.04721940325013 0.124657677371887 no 445 0.147499199118998 727 6051 A DNA damaging agent. SGTC_2829 7992743 58.44 µM 1.04641838709969 0.124826987705133 no 446 0.147683953575146 758 16462845 SGTC_2746 daunorubicin 9.88 µM 1.04618068738 0.124877261062523 no 447 0.147738808847284 635 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1726 st035556 14.5795 µM 1.04568664241594 0.124981796547763 no 448 0.147852865968418 804 5919439 SGTC_1414 3917-0015 5.4 µM 1.04506025997176 0.125114421318392 no 449 0.147997559764712 756 6618702 SGTC_2625 euphol 100 µM 1.04233377211946 0.125692849004578 no 450 0.14862847992315 795 6708538 A triterpene alcohol. SGTC_3090 9117696 49.47 µM 1.04101233611778 0.125973863446123 no 451 0.148934911472824 759 7923821 SGTC_3246 9135460 32.98 µM 1.03440365634472 0.127385827415895 no 452 0.150473747903047 694 41446951 SGTC_2467 5474540 200 µM 1.0320656034884 0.12788798525316 no 453 0.151020692948065 766 5413519 SGTC_956 1185-0240 191 µM 1.02812535907417 0.128737364573563 no 454 0.151945431628976 744 1416193 SGTC_3048 9093155 49.47 µM 1.02569050014286 0.129264187594069 no 455 0.152518746817324 700 25236002 SGTC_1514 1189-1591 158 µM 1.02456130297547 0.129509015054349 no 456 0.152785115693411 801 767698 YMR146C TIF34 SGTC_1705 st027868 56.3335 µM 1.02393139581728 0.129645728201299 no 457 0.152933839898179 775 292948 SGTC_2593 nobiletin 86.24 µM 1.02330979242922 0.129780737084482 no 458 0.15308069760788 717 72344 An anti-infammatory. SGTC_1115 galangin 695.678 nM 1.02301620340112 0.129844536867224 no 459 0.153150092352079 829 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_387 norethindrone acetate 66.7 µM 1.02244213660781 0.129969349963653 no 460 0.153285843001674 733 541197 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.02208383365388 0.130047293958394 no 461 0.153370611969488 750 140250 A respiratory chain inhibitor. SGTC_1399 3562-5772 25 µM 1.02062992477422 0.130363904269103 no 462 0.153714903069546 697 23847490 SGTC_967 1306-0166 352 µM 1.01465055979306 0.131671603434403 no 463 0.155136214602842 796 4437607 SGTC_2043 5101342 149 µM 1.01335013204485 0.131957203921217 no 464 0.155446474909627 763 678451 SGTC_3107 9121808 49.47 µM 1.01326677126669 0.131975526211339 no 465 0.15546637735029 748 662681 SGTC_115 0527-0192 112.043 µM 1.01318952791328 0.131992505487642 no 466 0.155484820752399 875 4233931 SGTC_1671 st016596 74.5 µM 1.01178919081075 0.132300582349845 no 467 0.155819429653891 835 2829167 SGTC_3075 9116269 49.47 µM 1.0103555736251 0.132616493973079 no 468 0.156162482263973 776 17015205 YNL244C SUI1 SGTC_2931 9014674 55.67 µM 1.00950619439073 0.132803907981114 no 469 0.156365966195727 754 2996810 SGTC_3291 9121177 71.43 µM 1.00491160725538 0.133820856659467 no 470 0.157469707390662 700 17015612 SGTC_2932 9016711 44.54 µM 1.00485615076992 0.133833163794502 no 471 0.15748306070113 832 7117328 SGTC_1377 2944-0135 198 µM 1.00108813907736 0.13467119932705 no 472 0.158392099382816 820 1894137 SGTC_2651 TUB2.036 5 µM 1.00036354164006 0.134832767480437 no 473 0.15856730348715 970 15992207 YFL037W TUB2 SGTC_2840 9008771 71.43 µM 1.00016981885883 0.13487598561619 no 474 0.158614166228178 762 2992978 SGTC_1917 st066507 28.5 µM 0.999404200854176 0.135046882384693 no 475 0.158799462829413 812 3156428 SGTC_3354 9151612 71.43 µM 0.999170456703757 0.135099086962399 no 476 0.158856062378978 823 27261949 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.999037833752555 0.135128713215212 no 477 0.158888181999321 824 3256 An antibiotic and ribosome inhibitor. SGTC_219 mitoxanthrone 164.414 µM 0.996044170356899 0.13579864428147 no 478 0.159614342141439 758 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_271 rotenone 740 µM 0.995539109976003 0.13591189208428 no 479 0.159737066267604 816 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1590 st077108 57.8 µM 0.991267501663667 0.136872285043082 no 480 0.160777488686869 805 5489485 SGTC_2032 5185112 25.99 µM 0.989540639069821 0.137261851962768 no 481 0.161199348416529 758 5718189 SGTC_918 glabranin 770.725 nM 0.989016155620405 0.137380321180862 no 482 0.16132761867921 809 124049 Also referred to as licorice root. SGTC_461 N-acetylfarnesylcysteine 136 µM 0.987923239101547 0.137627411144061 no 483 0.161595121577666 766 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1540 guanosine 70.6 µM 0.986764332822254 0.137889751438797 no 484 0.161879091852383 781 6802 Guanosine is a purine nucleoside SGTC_235 0330-0087 5 mM 0.985381662575299 0.138203190966985 no 485 0.162218316768341 846 46494818 YHR062C RPP1 SGTC_188 3229-0966 278.469 µM 0.98338737227234 0.138656134563019 no 486 0.162708411425712 942 5722370 SGTC_1686 st019653 115.5 µM 0.981364559043317 0.139116588267354 no 487 0.163206498396059 834 97252 SGTC_287 k060-0039 29.6 µM 0.981301330706893 0.13913099771102 no 488 0.16322208336397 831 5861974 SGTC_372 0155-0182 15.9 µM 0.981298933743893 0.139131543987718 no 489 0.163222674203401 882 771486 SGTC_456 gingerol 170 µM 0.976983231092158 0.140117476621668 no 490 0.164288727110282 838 442793 A herb. SGTC_946 3434-1334 87.4 µM 0.975336798178728 0.14049485596317 no 491 0.164696611440736 808 4047976 SGTC_310 1273-0058 1.06 µM 0.974532835533836 0.140679382970749 no 492 0.16489602190271 959 2734232 SGTC_510 ag-490 170 µM 0.974269954724759 0.140739755532272 no 493 0.164961259318051 900 5328779 SGTC_3030 9087619 49.47 µM 0.973391341704194 0.14094166320565 no 494 0.165179420236943 835 25236973 SGTC_2655 perillic acid 100 µM 0.97316528972321 0.140993642331783 no 495 0.16523557947004 790 5702197 An apoptosis inducer. SGTC_112 phenothiazine 287.218 µM 0.972836244115857 0.141069327381517 no 496 0.165317348011071 883 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_674 0498-0004 451 µM 0.972824729449085 0.141071976413303 no 497 0.165320209904612 792 4231473 SGTC_2245 6637752 200 µM 0.971296093269713 0.141423949671228 no 498 0.165700426839305 741 681890 SGTC_1049 3226-0134 66 µM 0.970599726935748 0.141584487340376 no 499 0.165873821003278 860 5702385 SGTC_2970 9090938 41.86 µM 0.970219286201723 0.141672244843858 no 500 0.165968599690746 892 17217104 SGTC_3274 9138298 49.47 µM 0.965516925891304 0.142759995971841 no 501 0.16714298121837 891 17015756 SGTC_997 3996-0078 137 µM 0.964115246834142 0.143085322112937 no 502 0.167494074709472 848 735687 SGTC_1340 1486-1359 257 µM 0.963850203562016 0.143146894245332 no 503 0.167560516299951 837 4309068 SGTC_509 pifithrin 175 µM 0.960718931340805 0.143875674043242 no 504 0.168346754895926 902 4817 A p53 inhibitor. SGTC_3207 9114163 49.47 µM 0.957242590584363 0.144687692985456 no 505 0.169222412270195 893 849233 SGTC_3012 9080433 71.4286 µM 0.956276993879097 0.144913788030257 no 506 0.169466154948367 893 17688859 SGTC_1397 3532-0190 20.1 µM 0.955766576503483 0.145033398614533 no 507 0.169595089047393 779 5322280 SGTC_2240 6690706 185.951 µM 0.955660972231825 0.145058154085061 no 508 0.169621773093941 726 805876 SGTC_2435 5706476 10.6 µM 0.955256217296553 0.145153061991915 no 509 0.169724071356488 896 5725375 SGTC_864 0469-0573 172 µM 0.954193729347453 0.145402395496124 no 510 0.169992794094408 799 689425 SGTC_2785 7756463 72.73 µM 0.951042292164301 0.146143635314485 no 511 0.170791453650676 857 2201551 SGTC_3330 9141424 71.43 µM 0.950181554352959 0.146346527317557 no 512 0.171010004758684 900 27261020 SGTC_132 0417-1715 25.805 µM 0.947179800581341 0.1470555761535 no 513 0.171773583233776 884 6769098 SGTC_385 1494-0393 12.4 µM 0.945340657023632 0.147491139232144 no 514 0.172242494018661 878 3090647 SGTC_46 0329-0187a 2.197 µM 0.944609443854326 0.147664551828377 no 515 0.172429151926553 928 46494817 SGTC_3084 9116877 49.47 µM 0.944517824841463 0.147686289576144 no 516 0.172452548745044 803 27241325 SGTC_516 3992-2719 87.3 µM 0.943829001775628 0.147849790022498 no 517 0.172628518861365 819 5350887 YDR037W KRS1 SGTC_43 0570-0105 72.5 µM 0.943448909273672 0.147940061419791 no 518 0.172725668152213 926 1114046 YDL195W SEC31 SGTC_2504 purpurogallin 52.29 µM 0.943008374824263 0.148044733841752 no 519 0.172838309626169 822 5281571 An antioxidant. SGTC_1188 1403-0014 4.57 µM 0.942322392793037 0.148207824070596 no 520 0.173013803456159 901 9614867 SGTC_220 paclitaxel 373.376 µM 0.941260613476604 0.14846049594951 no 521 0.17328566073652 793 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1487 3970-0795 2.82 µM 0.939401310268343 0.148903648306528 no 522 0.173762370273611 893 3765103 SGTC_1448 4255-0083 152 µM 0.938910286230216 0.14902082794946 no 523 0.173888403773406 904 5399660 SGTC_1668 st014914 51.6 µM 0.935044132493852 0.149945611632638 no 524 0.174882778048987 888 2839556 SGTC_225 nsc-122657 1.016 µM 0.934461424247726 0.150085326562872 no 525 0.175032962875494 743 275685 SGTC_1101 ebselen 5.29 µM 0.934388800257059 0.150102745569631 no 526 0.175051686417048 946 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2268 7933382 153.85 µM 0.93287286751497 0.150466652691035 no 527 0.175442806404958 995 935025 YOR257W CDC31 SGTC_2125 5246583 200 µM 0.931886588921653 0.15070372905275 no 528 0.175697569569325 951 835267 SGTC_1916 st067606 49.2 µM 0.931739056226056 0.150739213545728 no 529 0.175735698514699 914 19590279 SGTC_3117 9124945 49.47 µM 0.931120984933579 0.150887932223571 no 530 0.175895492330644 781 17592065 SGTC_218 alverine citrate 93.75 µM 0.930112393597946 0.15113082645832 no 531 0.176156447249853 851 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2884 9058502 51.95 µM 0.928156287988998 0.151602647178692 no 532 0.176663252584647 870 6471554 SGTC_2620 irigenin 100 µM 0.927646002065788 0.151725891099467 no 533 0.176795613500201 900 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1207 2099-0101 141 µM 0.926323590327276 0.152045588893816 no 534 0.177138919945043 946 5837381 SGTC_1499 4480-0877 67.3 µM 0.926185531156126 0.15207899096839 no 535 0.17717478523882 836 2861909 SGTC_1508 1080-0625 72.9 µM 0.925059214569719 0.152351674360678 no 536 0.177467553389173 834 767111 SGTC_2965 9082772 38.63 µM 0.925015678749309 0.152362220976395 no 537 0.177478875962639 912 16459634 SGTC_2745 rifampicin 24.3 µM 0.924474613114889 0.152493335348001 no 538 0.177619631592412 749 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_355 1311-2252 105 µM 0.923243646955967 0.152791909544324 no 539 0.177940123890952 848 5338538 SGTC_199 4063-0024 41.6 µM 0.923205646326292 0.152801132865505 no 540 0.17795002347086 911 306215 SGTC_3313 9133968 57.047 µM 0.922879843877488 0.152880225146369 no 541 0.178034912827665 932 1494643 SGTC_3095 9117207 49.47 µM 0.916189114617776 0.154510479006505 no 542 0.179783856911326 853 17015229 SGTC_224 benfluorex 43.875 µM 0.916156625656816 0.154518423153759 no 543 0.179792375711205 860 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1523 st012844 44.7 µM 0.914109241583889 0.155019590728238 no 544 0.180329723475462 884 4274103 SGTC_1554 st069299 38.7 µM 0.908515850739208 0.156394231393595 no 545 0.181802871555332 888 24207999 SGTC_3127 9126946 49.47 µM 0.907958053064536 0.156531755509223 no 546 0.181950192070803 785 27243249 SGTC_1694 st024011 44.9 µM 0.906585070363353 0.15687060126962 no 547 0.182313129851292 956 2787533 SGTC_433 pimozide 108 µM 0.905284222989188 0.157192089293279 no 548 0.18265741623421 788 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1096 rimcazole 32.2 µM 0.904293155302205 0.15743730973541 no 549 0.182919987624238 846 18528119 A dopamine reuptake inhibitor. SGTC_1180 1193-0155 285 µM 0.902498559612419 0.157881987065306 no 550 0.183396043121146 863 2921347 SGTC_2167 5876490 200 µM 0.902344324407085 0.157920242981752 no 551 0.183436993373867 920 686534 SGTC_1098 clofazimine 15.1 µM 0.902054514655426 0.157992142757668 no 552 0.183513954793209 933 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_169 k015-0017 16.025 µM 0.900391250020599 0.158405202657673 no 553 0.183956037816899 848 1840002 SGTC_763 3453-1109 128 µM 0.899172729059187 0.158708262848197 no 554 0.184280331883205 944 1560353 SGTC_1116 jasmonic acid  1.58368 µM 0.897512402267735 0.159121816690326 no 555 0.1847227792385 913 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2340 7987427 183.45 µM 0.896395238151403 0.159400476626042 no 556 0.18502085482285 858 2239331 SGTC_1225 1216-0074 20.6 µM 0.895644099838851 0.159588016402577 no 557 0.185221437325075 924 4241466 SGTC_73 0327-0325 16.231 µM 0.894780419219067 0.159803833489231 no 558 0.185452239743553 1001 53298 SGTC_2298 7976326 193.81 µM 0.894260895693184 0.159933744298093 no 559 0.185591158594482 849 2235818 SGTC_1379 2144-0755 36.5 µM 0.891497290434133 0.160625965460189 no 560 0.186331222265518 977 5392327 SGTC_1959 st077091 55.8 µM 0.89122819853983 0.160693471337263 no 561 0.186403379722288 957 821356 YKL052C ASK1 SGTC_1424 4048-1941 275 µM 0.890506240688582 0.160874677189186 no 562 0.186597059471978 1014 X1424 SGTC_2441 5730946 39.09 µM 0.890459140096467 0.160886503707948 no 563 0.186609699483853 933 1774275 SGTC_67 0335-0847 266 µM 0.888551751935962 0.161365907911543 no 564 0.187122015470395 1013 4552207 YOR254C SEC63 SGTC_1570 verbenone 133 µM 0.886998678809793 0.161756945765276 no 565 0.187539805898265 952 29025 A natural terpanoid with antifungal properties. SGTC_2311 7694451 200 µM 0.884960544124568 0.162271050179129 no 566 0.188088955988289 898 2163142 SGTC_1977 st070720 65.3 µM 0.884695050222062 0.162338097276674 no 567 0.18816056301626 874 682188 SGTC_488 nitrendipine 139 µM 0.878283609204343 0.163962699535036 no 568 0.189894914257493 971 4507 Dihydropyridine L-type calcium channel blocker. SGTC_3024 9090631 49.47 µM 0.876654464324582 0.164377185421925 no 569 0.190337173410205 907 25236383 SGTC_476 mead acid 10 µM 0.874283948924162 0.164981502471262 no 570 0.190981819149985 924 5312531 An omega 9 fatty acid. SGTC_2914 7968218 45.32 µM 0.874234298193774 0.164994175326661 no 571 0.190995335635102 890 2977111 SGTC_2226 7298446 200 µM 0.873838771584652 0.165095152071569 no 572 0.191103031328651 929 3283010 SGTC_938 3126-1755 342 µM 0.871557847872627 0.165678245362645 no 573 0.191724817353446 990 1777771 SGTC_1001 4048-4355 44.4 µM 0.871435368452293 0.165709593518956 no 574 0.191758240588427 922 21824233 SGTC_3160 9100216 49.47 µM 0.870968745099018 0.165829059182195 no 575 0.191885609457942 954 17191039 SGTC_359 0081-0058 15.9 µM 0.87058683896265 0.165926876826269 no 576 0.191989892561028 865 3494159 SGTC_1383 3049-0032 20.7 µM 0.870160813032288 0.166036038868615 no 577 0.192106263912111 988 712864 SGTC_1078 idebenone 36.1 µM 0.866165661454288 0.167061987183353 no 578 0.193199660645796 982 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2995 9067767 71.4286 µM 0.865513848750703 0.167229758656085 no 579 0.193378409090007 885 11673567 SGTC_33 0986-0033 35.816 µM 0.864793847131908 0.16741520761692 no 580 0.193575974423354 918 2848082 SGTC_2480 5767542 37.17 µM 0.860740424470231 0.168461709032663 no 581 0.194690511735775 982 2867358 SGTC_1413 3910-0535 34.4 µM 0.860283064578458 0.168580052458294 no 582 0.194816512985282 999 2876951 SGTC_1568 digitonin 820 nM 0.85732998400609 0.16934545825014 no 583 0.195631271048838 997 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1843 st055809 45.5 µM 0.85533052782485 0.169864959544702 no 584 0.19618409587537 907 16413835 SGTC_582 0987-0078 156 µM 0.853599892996001 0.170315439419975 no 585 0.196663358923877 1085 1625765 SGTC_697 0508-1955 564 µM 0.853130751709816 0.170437687438928 no 586 0.196793399854331 1010 6243113 SGTC_2177 5811945 192 µM 0.852833904724548 0.170515068330086 no 587 0.196875709544649 984 5343475 SGTC_623 k072-0108 16.9 µM 0.852713565897587 0.170546444184109 no 588 0.196909083014445 949 5382803 SGTC_1631 benzylvanillin 81.9 µM 0.852710804662953 0.17054716416217 no 589 0.196909848825612 947 75506 SGTC_1012 4112-3522 18 µM 0.850945693224731 0.171007806332092 no 590 0.197399760370172 1005 3112398 SGTC_3083 9117465 49.47 µM 0.850161853687534 0.17121262035008 no 591 0.19761755333881 1017 16420915 SGTC_2216 7189485 200 µM 0.849005475931689 0.171515063321366 no 592 0.197939122623135 999 731273 SGTC_2580 diallyl disulphide 81.36 µM 0.848642079319577 0.171610177766663 no 593 0.198040242366826 913 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1067 clotrimazole 1.36 µM 0.847625687101848 0.1718763844146 no 594 0.198323232068604 996 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1151 3909-8316 15.3 µM 0.846886155823191 0.172070243138632 no 595 0.19852928987447 966 800431 SGTC_1186 1319-0216 26 µM 0.845877131515713 0.17233497106429 no 596 0.198810645551112 1029 4565136 SGTC_2109 5483026 200 µM 0.845435605619156 0.172450891612631 no 597 0.198933835909945 987 759335 SGTC_1596 piperlongumine 63 µM 0.845107753442189 0.172536999827307 no 598 0.199025339864106 1026 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_252 miconazole 1.30953 nM 0.844463422220017 0.172706309056253 no 599 0.199205247400313 959 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2310 7668677 200 µM 0.838774692549066 0.17420571448734 no 600 0.200797877374232 965 2197143 SGTC_815 1582-0027 36.9 µM 0.836493634274655 0.174809260555051 no 601 0.201438628214072 992 3128206 SGTC_1666 st014829 29 µM 0.836380116765718 0.174839330823661 no 602 0.20147054733499 1016 3858230 SGTC_1281 0884-0031 11.8 µM 0.836224273203799 0.174880618417019 no 603 0.201514372731648 989 1548255 SGTC_62 0180-0423 3.232 µM 0.83511885218873 0.175173654892196 no 604 0.201825396558086 980 30102 YGL099W LSG1 SGTC_364 0083-0097 67.7 µM 0.834126904477691 0.175436875644938 no 605 0.202104737814339 974 5207356 SGTC_1183 1254-0324 198 µM 0.83267220168943 0.175823345120231 no 606 0.202514813163735 1006 5799357 SGTC_646 4092-0839 27.3 µM 0.831450819831905 0.176148244568218 no 607 0.202859500052336 1028 877796 SGTC_3306 9127676 59.7925 µM 0.829023258287663 0.176795126976614 no 608 0.203545623231291 975 41905287 SGTC_2076 5212012 200 µM 0.828410699828564 0.176958594947285 no 609 0.203718974489014 915 604802 SGTC_2115 tiliquinol 12.7705 µM 0.827098584117036 0.17730906876205 no 610 0.204090593338529 973 71208 A bioactive hydroxyquinoline. SGTC_1738 st035555 74 µM 0.827068719707153 0.177317050819607 no 611 0.204099056266839 1001 5331140 SGTC_2013 4024628 200 µM 0.823725555423959 0.178212034491432 no 612 0.205047757692049 960 5230760 SGTC_1932 st074806 40.9 µM 0.823020950879316 0.178401023686884 no 613 0.205248039701172 1128 17251235 SGTC_2986 9022445 71.43 µM 0.819630791378741 0.179312097403728 no 614 0.206213307396396 1006 6459286 SGTC_2096 5468907 200 µM 0.819029094823656 0.179474102925262 no 615 0.206384907010959 1035 759785 SGTC_3309 9129340 25.759 µM 0.817119364292893 0.179988903020419 no 616 0.206930108876579 1047 17158987 SGTC_1231 0242-0792 125 µM 0.816339171942701 0.180199483551329 no 617 0.2071530881007 1004 3707635 SGTC_411 enrofloxacin 100 µM 0.814310681436177 0.180747713661681 no 618 0.2077334960655 1065 71188 A bacterial gyrase inhibitor. SGTC_790 1575-0012 79.1 µM 0.813474439788782 0.180974024631533 no 619 0.207973047590659 1057 378741 YLR208W SEC13 SGTC_1998 st075797 76.8 µM 0.812925457046982 0.181122691607677 no 620 0.208130398970041 1073 24208315 SGTC_350 k064-0020 19.8 µM 0.812755333938607 0.181168777227623 no 621 0.208179174514738 1048 2790705 SGTC_2991 9074669 71.4286 µM 0.812173640493637 0.181326410972471 no 622 0.208346001252034 1037 17333109 SGTC_108 0509-0257 621.132 µM 0.810652398400825 0.181739059868035 no 623 0.208782658403283 1026 536624 SGTC_740 k014-0057 261 µM 0.809940570473463 0.181932350411572 no 624 0.208987166480142 1055 4012779 SGTC_2396 5342950 42.78 µM 0.808737218256716 0.182259402249297 no 625 0.209333157623722 1022 1886677 SGTC_39 0986-0283 58.349 µM 0.805920358633674 0.183026415084462 no 626 0.210144385827255 1079 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1979 st071809 45.3 µM 0.805151299444292 0.183236174457963 no 627 0.210366187897352 1045 4976333 SGTC_2316 5844804 197.44 µM 0.799836614824793 0.184689839061248 no 628 0.211902732981718 1156 776813 SGTC_2297 7971671 152.32 µM 0.798978297910186 0.1849252753088 no 629 0.212151497990418 1027 909016 SGTC_2763 lisinopril 49.32 µM 0.798342731212234 0.185099731318875 no 630 0.212335813532335 1003 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2664 lyso-paf C-16 73.48 µM 0.798296651385144 0.185112383693921 no 631 0.212349180406459 1078 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2861 9024595 19.48 µM 0.797983563462245 0.185198364079234 no 632 0.21244001422841 989 16482810 SGTC_1171 0368-0077 21.4 µM 0.797696250589323 0.185277287925285 no 633 0.212523390101703 995 3239779 SGTC_3236 9132701 49.47 µM 0.797650781929816 0.185289779921608 no 634 0.212536586490736 1015 24282524 SGTC_2513 baicalein 25.65 µM 0.796658120059025 0.185562632793787 no 635 0.212824806449897 1057 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.796655743844841 0.185563286242556 no 636 0.212825496658693 912 6708630 An antioxidant. SGTC_968 1309-0633 340 µM 0.796578483210927 0.185584533365458 no 637 0.212847938937263 1036 3761976 SGTC_2702 st077768 96.8 µM 0.796448260789842 0.185620348703821 no 638 0.21288576841415 955 6484119 SGTC_1861 st057647 17.4 µM 0.794532497311312 0.186147740592392 no 639 0.21344274903345 1051 688668 SGTC_448 monastrol 171 µM 0.794011327019497 0.186291374470011 no 640 0.213594418618386 1065 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2853 9015042 58.44 µM 0.793002056037 0.186569723476351 no 641 0.213888312444378 1030 6457456 SGTC_3176 9106582 49.47 µM 0.792568813184146 0.186689287413286 no 642 0.214014542429651 951 17018027 SGTC_2183 6420625 130.508 µM 0.792198788954762 0.186791442177308 no 643 0.214122387310786 1109 2897619 SGTC_1382 3002-2117 298 µM 0.791698328360263 0.186929662304436 no 644 0.214268298634667 1098 1497314 SGTC_1757 st041620 31.8375 µM 0.789430203671306 0.187556879220153 no 645 0.214930304289466 1071 5289815 SGTC_2989 9073649 71.4286 µM 0.788705937699291 0.187757438064904 no 646 0.215141948357228 1092 21367202 SGTC_1016 4226-1401 38 µM 0.788535505547696 0.187804652232119 no 647 0.215191769399218 1088 2901613 SGTC_343 4130-2827 29.8 µM 0.785995726183665 0.188509106135162 no 648 0.215934995481409 1057 1118244 SGTC_2405 ticlatone 3.52 µM 0.785375732347864 0.188681319800085 no 649 0.216116652421507 1047 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1280 0880-0253 10.1 µM 0.784801475755632 0.188840915663189 no 650 0.216284987368161 1040 6836607 SGTC_2073 5212005 126 µM 0.784075147057934 0.189042894105997 no 651 0.216498008717037 941 691789 SGTC_764 1951-2361 146 µM 0.77976312015552 0.190244726126972 no 652 0.217765158955648 1025 5438930 SGTC_352 k048-0007 5.11 µM 0.778649156963879 0.190555967089226 no 653 0.218093206884292 1095 6811911 SGTC_1134 3477-0009 42.5 µM 0.778494954772127 0.190599075750945 no 654 0.218138639893597 1085 3973534 SGTC_1418 3966-3099 2.4 µM 0.77802120263694 0.190731555027057 no 655 0.218278256886411 1085 740335 SGTC_1346 1488-2224 62.4 µM 0.776835962568383 0.191063241088594 no 656 0.218627778173004 1079 3722427 SGTC_373 0844-0104 25.9 µM 0.775861835932306 0.191336112315485 no 657 0.218915284238129 1122 5375804 SGTC_2471 5466956 24.79 µM 0.775679399744522 0.191387242671257 no 658 0.218969153061605 1045 724419 SGTC_945 3381-0768 11.3 µM 0.775126756084333 0.191542180068822 no 659 0.219132381374463 1108 1126236 YIL048W NEO1 SGTC_1719 st032227 49.2 µM 0.772324107014553 0.19232910406043 no 660 0.219961245432792 1118 3125804 SGTC_3244 9134489 49.47 µM 0.771304420882009 0.19261589998061 no 661 0.220263256289471 1073 16584271 SGTC_1575 cyproterone acetate 48 µM 0.767933721768066 0.193565798057005 no 662 0.221263280981156 1054 9880 An androgen receptor antagonist and liver toxin. SGTC_1970 st070122 35.8 µM 0.767579745722885 0.193665717694415 no 663 0.221368449657797 1098 102928 SGTC_2916 7875993 68.79 µM 0.767268634500427 0.193753563500831 no 664 0.221460906503072 1062 1299250 SGTC_1769 st044406 64.4 µM 0.767158808670939 0.193784579878425 no 665 0.221493550101237 1076 670903 SGTC_152 4469-0003 551.229 µM 0.767131885128374 0.193792183932029 no 666 0.221501553021975 1088 697280 SGTC_2983 9022671 12.99 µM 0.763488553192407 0.194822852311989 no 667 0.222586043207917 1049 6405161 SGTC_2274 7947094 46.08 µM 0.763150885107213 0.194918544335538 no 668 0.222686708027954 1125 2971028 SGTC_2312 7706453 155.7 µM 0.763055016852404 0.194945717723777 no 669 0.222715292776642 1074 976098 SGTC_3150 9097574 49.47 µM 0.762335252987701 0.195149804830863 no 670 0.222929969377978 1074 17217476 SGTC_1291 0993-0025 5.79 µM 0.761782319538276 0.195306675784286 no 671 0.22309496720665 1103 4353356 SGTC_896 0964-0007 44.5 µM 0.756508783796062 0.196806660188843 no 672 0.224672104001495 1118 6756758 SGTC_987 1497-1013 404 µM 0.755508572486616 0.197091941503513 no 673 0.224971945337369 1109 1676435 SGTC_1613 st002381 52.1 µM 0.754669947685984 0.197331327714542 no 674 0.225223521296169 1135 551167 SGTC_550 4123-0385 25.7 µM 0.751694215652575 0.198182171236642 no 675 0.226117484872897 1102 5731123 SGTC_3179 9107801 49.47 µM 0.748961386424457 0.198965509838746 no 676 0.226940239593287 1130 4818259 SGTC_1461 k072-0203 53.8 µM 0.748841940682879 0.198999790290819 no 677 0.2269762387977 1094 5418714 SGTC_2581 avocatin a 64 µM 0.748120715494703 0.199206854661481 no 678 0.227193673964867 1106 6710728 A skin care supplement. SGTC_3126 9127922 49.47 µM 0.748005827590749 0.199239851055721 no 679 0.227228321238593 1143 45595682 SGTC_3224 9130643 49.47 µM 0.746683256696677 0.199619937196641 no 680 0.227627389415081 1133 17644395 SGTC_445 e6 berbamine 66 µM 0.745975715701238 0.199823452410917 no 681 0.227841042409706 1163 6610268 A calcium/calmodulin antagonist. SGTC_2737 bleomycin 30.5 nM 0.745627501736642 0.199923657558229 no 682 0.227946232445223 1167 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3128 9127691 49.47 µM 0.744493929201936 0.200250073710603 no 683 0.228288856284818 1019 41316314 SGTC_989 1501-0895 10.3 µM 0.74371027772382 0.200475915982946 no 684 0.228525885134769 1127 2830112 SGTC_1054 3429-0080 167 µM 0.743144591489954 0.200639037393007 no 685 0.228697072533068 1144 1162877 SGTC_1075 aripiprazole 15.2 µM 0.74303013837104 0.200672050809876 no 686 0.228731716976427 1184 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1195 1502-0147 41.1 µM 0.741959108511703 0.200981141907254 no 687 0.229056055651197 1156 817940 SGTC_705 1124-0212 310 µM 0.741789564739123 0.201030097125879 no 688 0.229107422029477 1128 9554485 SGTC_1274 0865-0114 173 µM 0.739670728734343 0.201642507272307 no 689 0.229749906707957 1134 870624 SGTC_2223 6903751 107.57 µM 0.738851227120495 0.201879668358282 no 690 0.22999867065049 1075 5598863 SGTC_192 3455-0609 60.9 µM 0.738139525209973 0.202085767991685 no 691 0.230214833683545 1171 3769639 SGTC_2402 5553605 200 µM 0.737739959469474 0.20220153221008 no 692 0.230336242347212 1150 6758546 SGTC_817 1391-0715 46 µM 0.736787064553462 0.202477769849846 no 693 0.230625925380773 1089 1353946 SGTC_2250 alverine citrate 130 µM 0.735652477637614 0.202806972837941 no 694 0.230971108680477 1103 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1041 0206-0046 107 µM 0.735212336980936 0.202934766693037 no 695 0.231105093351804 1105 50494 SGTC_191 3914-0123 66.505 µM 0.73498472856063 0.203000871150864 no 696 0.231174397394247 1061 3144412 SGTC_3060 1327-0027 12.5 µM 0.734929750593815 0.203016840364546 no 697 0.231191139266407 1085 16000455 YPR107C YTH1 SGTC_2522 biochanin a 4.94 µM 0.732853088881691 0.203620588523308 no 698 0.23182401874902 1108 5280373 A possible chelator. SGTC_3076 9116187 49.47 µM 0.732586442889826 0.203698188041433 no 699 0.231905351131297 1093 27241210 SGTC_1032 k061-1018 98.7 µM 0.731316235818446 0.204068086648172 no 700 0.232293007875622 1216 4005393 SGTC_978 1416-0512 87.4 µM 0.729850228596142 0.204495501510629 no 701 0.232740869049396 1161 6814003 SGTC_2479 5617353 43.85 µM 0.729328528629458 0.204647731737799 no 702 0.232900362646356 1147 2731746 SGTC_1352 1496-0991 99 µM 0.728290589279031 0.204950799235937 no 703 0.233217860923467 1151 3000039 SGTC_1791 st048313 56.1 µM 0.728171502762613 0.20498558831582 no 704 0.233254303999993 1092 1204976 SGTC_3124 9127567 49.47 µM 0.726617301178575 0.205439943399318 no 705 0.233730213330217 1103 17592030 SGTC_127 0180-0333 59.125 µM 0.725955933369879 0.205633468830718 no 706 0.233932892738446 1142 771601 SGTC_1398 3558-0053 112 µM 0.724994049396616 0.205915122532725 no 707 0.234227840511582 1079 4532369 SGTC_2004 4023728 41.89 µM 0.724489486782343 0.206062957308828 no 708 0.234382639602759 1135 360084 YDR527W RBA50 SGTC_1140 3229-1848 2.98 µM 0.723866063194932 0.206245704760814 no 709 0.234573983235821 1157 2849525 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.722226835995369 0.2067266782548 no 710 0.235077513349572 1095 1241132 A phosphatase inhibitor. SGTC_2808 7946468 45.46 µM 0.722006954810381 0.206791245123268 no 711 0.235145100804832 1140 2970879 SGTC_2533 agelasine 13.65 µM 0.7215641001163 0.206921323134185 no 712 0.235281258808215 1191 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2821 7996764 71.43 µM 0.720712836255096 0.207171497565891 no 713 0.235543106563414 1230 2987135 SGTC_2617 dihydrotanshinone i 20.83 µM 0.720417269333259 0.207258402337089 no 714 0.23563406018725 1195 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2894 9048625 32.47 µM 0.719985578705001 0.207385369936803 no 715 0.235766937416143 1197 4092861 SGTC_1806 st050005 60.3 µM 0.719058253036307 0.207658267715131 no 716 0.23605251403899 1144 5194765 SGTC_52 0329-0193 875 nM 0.718895620924357 0.207706149719246 no 717 0.236102617406239 1211 3739292 SGTC_1051 3253-3903 78 µM 0.717623501913963 0.208080910869821 no 718 0.2364947312975 1164 5509239 SGTC_1109 tnp00067 928.257 nM 0.716700488214462 0.20835307667097 no 719 0.236779462294033 1153 676295 SGTC_2507 purpurin 79.67 µM 0.715721963528541 0.208641839984075 no 720 0.237081523057956 1170 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2094 5332512 191.667 µM 0.715301708695607 0.208765929857127 no 721 0.237211316482129 1186 755774 SGTC_2295 7971645 200 µM 0.715115933577937 0.208820798078522 no 722 0.237268704557444 1149 2978226 YKL099C UTP11 SGTC_2060 5238662 140 µM 0.71441309886084 0.209028455440806 no 723 0.237485887283172 1127 790130 SGTC_499 genistein 192 µM 0.712503810286622 0.209593181484826 no 724 0.238076426405569 1182 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3106 9121286 49.47 µM 0.71203614812344 0.209731642480149 no 725 0.238221195983738 1190 15943471 SGTC_528 3492-0019 172 µM 0.709525035986423 0.210476028007567 no 726 0.238999360395672 1216 2869262 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.708562387045041 0.210761803060742 no 727 0.239298042184021 1020 4000243 SGTC_2602 kawain 100 µM 0.706890049366099 0.211258799346908 no 728 0.239817404084197 1184 5369129 SGTC_2277 7947813 106.88 µM 0.706317748758106 0.211429036962253 no 729 0.239995279130489 1188 1246798 SGTC_2951 9072950 58.06 µM 0.705975964760485 0.211530742978117 no 730 0.240101542297435 1221 16488155 SGTC_934 2950-0684 338 µM 0.704712896473027 0.211906847651212 no 731 0.240494461987122 1187 1121253 SGTC_3200 9114385 49.47 µM 0.703678731986063 0.21221508255508 no 732 0.240816434021708 1176 17018030 YLR208W SEC13 SGTC_1150 3909-7983 10.9 µM 0.699371933070226 0.213501548343484 no 733 0.242159811696705 1194 23965914 SGTC_2634 4'-methoxyflavone 100 µM 0.699120398044025 0.213576823521303 no 734 0.242238395932307 1170 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1213 1315-0166 115 µM 0.69642908114806 0.214383203027657 no 735 0.24308007806095 1149 768401 SGTC_1685 st024049 53.0905 µM 0.696346285302483 0.214408038579255 no 736 0.2431059966763 1188 1941139 SGTC_1378 2093-0007 380 nM 0.695762566141012 0.214583179224505 no 737 0.2432887679603 1198 3618014 SGTC_2248 tofa 1.1 µM 0.693846048086295 0.215158800815163 no 738 0.243889380588012 1137 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1253 0550-0034 176 µM 0.693699946572046 0.215202718792573 no 739 0.243935199762644 1159 5969915 SGTC_320 4092-0846 5.34 µM 0.692995174780573 0.215414645603268 no 740 0.244156289813061 1176 1359356 SGTC_279 1273-0055 2.93 µM 0.69256009811842 0.215545534768071 no 741 0.244292829222433 1245 2847562 SGTC_297 0986-0032 24 µM 0.692312758659236 0.215619965329072 no 742 0.244370469713529 1181 2847425 SGTC_230 MPP+ 141.667 µM 0.69200196130237 0.215713513066664 no 743 0.244468048651765 1175 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1329 1447-1697 50.6 µM 0.690997706920861 0.21601594710311 no 744 0.24478349104319 1188 2840515 SGTC_394 menadione 8.33 µM 0.690227780123522 0.216247978982492 no 745 0.245025478021254 1174 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_119 0121-0043 24.815 µM 0.68824444005452 0.216846359908717 no 746 0.245649431479242 1279 1092378 SGTC_1942 st076330 65.2 µM 0.688197604532762 0.21686050191632 no 747 0.245664176114509 1246 24208414 SGTC_1824 st053723 68.6 µM 0.686745100045855 0.217299350935333 no 748 0.246121685577274 1195 675225 SGTC_2158 5657123 3.6195 µM 0.686648789977575 0.217328467470284 no 749 0.246152037442839 1187 2858827 SGTC_2518 prenyletin 46.28 µM 0.685664582952824 0.217626142829136 no 750 0.246462322747602 1140 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1864 st057645 30.4 µM 0.68553578347347 0.217665115888504 no 751 0.246502944123671 1248 688666 SGTC_2430 5571206 200 µM 0.684493122327777 0.217980759908337 no 752 0.246831915439273 1254 1731771 SGTC_2198 6589944 200 µM 0.683620807534636 0.218245037743231 no 753 0.247107321018401 1172 5290268 SGTC_587 k089-0003 57 µM 0.682066127945816 0.218716503306101 no 754 0.247598568758813 1159 9659696 SGTC_2064 5220758 200 µM 0.681891061444954 0.218769629928698 no 755 0.247653918942122 1259 788518 SGTC_3178 9107506 49.47 µM 0.681671499946256 0.218836269738746 no 756 0.247723346298776 1243 8897194 SGTC_522 1273-0010 11.6 µM 0.681594882751576 0.218859526816283 no 757 0.247747575803356 1275 5705015 SGTC_2846 9008642 19.48 µM 0.679473907008862 0.219503911349827 no 758 0.248418817551604 1214 2992898 SGTC_662 k832-1615 104 µM 0.678663410985012 0.219750439825132 no 759 0.248675577286924 1202 5878478 SGTC_2505 galangin 7.89 µM 0.678659218335138 0.219751715516048 no 760 0.248676905857805 1144 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_482 fipronil 114 µM 0.677803068826446 0.220012303828287 no 761 0.248948282513366 1244 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_25 0118-0223 35.662 µM 0.677473944919572 0.22011252723175 no 762 0.249052647974416 1254 5333628 SGTC_123 0083-0120 66.675 µM 0.67741718725615 0.220129813479519 no 763 0.249070648229061 1174 16001701 SGTC_1259 0671-0132 43 µM 0.676104748242771 0.220529750115532 no 764 0.249487071096215 1174 X1259 SGTC_2089 5281248 129.67 µM 0.675971961828802 0.22057023700589 no 765 0.249529223405279 1233 2737878 SGTC_2927 9011802 47.9 µM 0.674714678875301 0.220953796541755 no 766 0.249928528357515 1215 43912568 SGTC_2667 digitoxin 100 µM 0.674357694984629 0.221062771232269 no 767 0.250041965921301 1196 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_481 bay k-8644 50 µM 0.673912338869259 0.221198765981183 no 768 0.250183523517303 1179 2303 A calcium channel antagonist. SGTC_3069 9117009 49.47 µM 0.672117761451722 0.221747246125901 no 769 0.250754365033174 1114 41904981 SGTC_759 3486-0358 89.3 µM 0.67080871635288 0.222147821704961 no 770 0.251171197009114 1260 875103 SGTC_779 1360-0071 233 µM 0.670729008181715 0.222172226211108 no 771 0.251196589871799 1298 7566 SGTC_633 0437-0093 97.7 µM 0.669997306010712 0.222396325287569 no 772 0.251429753770522 1238 2831118 SGTC_3018 9082602 49.47 µM 0.669654035433506 0.222501503489509 no 773 0.251539179630326 1231 17332089 SGTC_1545 lovastatin 49.4 µM 0.66963987728573 0.222505842158987 no 774 0.251543693425116 1276 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_102 gallobenzophenone 83.616 µM 0.669502094887321 0.222548067170472 no 775 0.251587622413561 1288 70837 SGTC_2247 cerulenin 830 nM 0.668480246543336 0.222861366985371 no 776 0.251913543477816 1288 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.667159148379585 0.22326678932197 no 777 0.252335241075626 1201 77254 SGTC_1704 st028805 70.8 µM 0.666603973575649 0.223437288123863 no 778 0.252512565148323 1234 2876101 SGTC_2825 7998094 58.44 µM 0.665235855397212 0.223857764642441 no 779 0.252949825260037 1221 2987815 SGTC_421 streptovitacin 30 mM 0.664973716722566 0.223938381473597 no 780 0.253033652074105 1275 91467 include heat shock SGTC_2241 6772625 37.8075 µM 0.664084281607369 0.224212036859964 no 781 0.253318184895534 1191 2285411 SGTC_312 4092-0653 6.84 µM 0.662351766445581 0.224745630229822 no 782 0.25387290396556 1254 1148278 SGTC_11 0438-0307 1.3 µM 0.662151506740441 0.224807354153223 no 783 0.253937064474807 1249 4011476 SGTC_1529 apigenin 74 µM 0.661877622003943 0.224891786298288 no 784 0.25402482722661 1321 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1246 0422-0085 105 µM 0.661514497676793 0.22500375659604 no 785 0.254141210159579 1238 264295 SGTC_3118 9124250 49.47 µM 0.661507944267395 0.225005777646471 no 786 0.254143310812796 1181 1504786 SGTC_532 1548-0774 215 µM 0.660807497569907 0.225221852466913 no 787 0.254367886987999 1348 5932993 SGTC_1348 1493-0373 93.8 µM 0.657236520067726 0.226325257989584 no 788 0.255514423341001 1259 3010129 SGTC_66 0109-0187 42.4 µM 0.656762016204527 0.226472105639355 no 789 0.25566697559735 1262 759417 SGTC_2056 5235370 200 µM 0.654999405219319 0.227018062625792 no 790 0.256234068501672 1250 5511916 SGTC_323 4013-0906 34.3 µM 0.653557634592108 0.227465192710894 no 791 0.256698423093044 1282 2910086 SGTC_2212 7123476 200 µM 0.653529815826818 0.227473824899079 no 792 0.256707387057312 1223 1085715 SGTC_1991 st073000 8.92 µM 0.653383246201544 0.227519308634032 no 793 0.256754618475972 1331 4301969 YIL048W NEO1 SGTC_214 4373-3496 70 µM 0.651060967875665 0.228240645076523 no 794 0.257503565699921 1336 3779166 SGTC_2262 9014885 67.46 µM 0.650982455126548 0.228265054826322 no 795 0.25752890629993 1209 6457424 SGTC_931 2812-0076 566 µM 0.650751524710365 0.228336859997974 no 796 0.25760344839369 1291 3450959 SGTC_56 0957-0365 83.25 µM 0.650453736959205 0.228429472429679 no 797 0.257699587922497 1231 6752360 SGTC_1468 k284-1086 134 µM 0.646866462515017 0.229546777198039 no 798 0.258859186510176 1284 15996457 SGTC_1825 st052143 62.6 µM 0.646033137075613 0.229806765169592 no 799 0.259128947684374 1308 674173 SGTC_2975 9084847 53.72 µM 0.645199609308239 0.230066981120129 no 800 0.259398919674966 1306 27211724 SGTC_2828 7998861 71.43 µM 0.644840516534045 0.23017913575859 no 801 0.259515271293657 1212 2988188 SGTC_1969 st069479 40.1 µM 0.642955024021912 0.230768529017545 no 802 0.260126642036875 1273 3895485 SGTC_1409 3909-8004 61.9 µM 0.642659560387742 0.230860965452911 no 803 0.260222513332468 1274 2119279 SGTC_2361 9034121 116 µM 0.641694330905391 0.231163083634972 no 804 0.260535835423993 1281 6496917 SGTC_961 1252-1571 372 µM 0.639248861439591 0.231929505634165 no 805 0.261330525169378 1316 6813498 SGTC_180 1486-1293 102.781 µM 0.638801473839803 0.232069872045862 no 806 0.261476044685921 1334 4140536 SGTC_2531 methyl deoxycholate 70.07 µM 0.638582295943057 0.232138655657414 no 807 0.261547350760245 1262 16667744 Haematoxylin. SGTC_2458 5808907 16.39 µM 0.637902496821554 0.232352066111782 no 808 0.261768576167063 1327 2731747 SGTC_726 3448-4391 34.2 µM 0.637125290781119 0.232596189341069 no 809 0.262021618034501 1370 1356692 SGTC_2557 derrustone 83.84 µM 0.635780930033115 0.233018794360632 no 810 0.262459609331311 1269 629853 An antioxidant. SGTC_1341 1486-1360 280 µM 0.633097503974796 0.233863613372228 no 811 0.263334986080803 1282 3976547 SGTC_3303 9125618 40.5795 µM 0.631752094290967 0.234287824657506 no 812 0.263774440807793 1341 22695467 SGTC_641 4092-0595 30 µM 0.630470128911071 0.234692427739735 no 813 0.264193520224379 1311 786260 SGTC_3136 9095672 49.47 µM 0.628536022307392 0.235303584606033 no 814 0.264826428246522 1154 17217380 SGTC_766 1391-0721 126 µM 0.628021190983033 0.235466413699904 no 815 0.264995029044383 1326 1020919 YIL115C NUP159 SGTC_1323 1348-1351 11.2 µM 0.627722351020111 0.235560958296838 no 816 0.265092920392719 1300 6989654 SGTC_1017 4239-0030 168 µM 0.626661364028667 0.235896793984781 no 817 0.265440617424812 1270 1149593 SGTC_2473 5854593 8.94 µM 0.625894482438331 0.23613970030608 no 818 0.265692076899602 1287 2872951 SGTC_737 1950-0117 57.9 µM 0.624510600688401 0.236578387121198 no 819 0.266146155358891 1262 5393513 SGTC_2766 oltipraz 83.91 µM 0.6229969130565 0.237058735088582 no 820 0.2666432752004 1341 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_185 k048-0037 25.491 µM 0.62135893788483 0.23757912720396 no 821 0.267181741449785 1307 6827589 SGTC_604 1000-0114 314 µM 0.620401427705067 0.237883622625439 no 822 0.267496766353537 1368 1572745 SGTC_1837 st055472 66.5 µM 0.618402582996924 0.238519959313232 no 823 0.268154997784836 1359 676091 SGTC_2284 7945075 39.21 µM 0.618062716392015 0.238628249221506 no 824 0.26826699890373 1364 1245402 SGTC_7 0192-1582 4.227 µM 0.618040917634559 0.238635195762999 no 825 0.268274183364112 1354 252616 SGTC_1854 st056233 32.9 µM 0.617217979205678 0.238897519894967 no 826 0.268545479171678 1283 5393174 SGTC_1203 3992-3522 103 µM 0.617079854263472 0.238941564770245 no 827 0.26859102794657 1533 5322312 SGTC_3347 9188721 44.724 µM 0.616583647958255 0.239099830199779 no 828 0.268754691453667 1307 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2184 6075246 200 µM 0.616320089892857 0.239183915565643 no 829 0.268841641060358 1341 2267320 SGTC_496 calpeptin 138 µM 0.615704798736109 0.23938028047315 no 830 0.269044684789963 1272 73364 A calpain inhibitor. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.615354542943427 0.239492100927577 no 831 0.269160302228767 1308 115019 SGTC_2545 solidagenone 89.61 µM 0.61525682680509 0.239523302252923 no 832 0.269192562215182 1200 6708572 An anti ulcer agent SGTC_2415 st077333 57.7 µM 0.613895739435045 0.239958135950479 no 833 0.269642112902325 1409 2766255 SGTC_1401 3807-4679 7.6 µM 0.613587069125066 0.240056808318165 no 834 0.269744115263108 1318 3291456 SGTC_1647 st011722 22.4 µM 0.613530019547345 0.2400750477285 no 835 0.269762969828821 1328 2854783 SGTC_1446 4239-0190 62 µM 0.612475214075073 0.24041241733041 no 836 0.270111695990149 1313 1340085 SGTC_3271 9137798 49.47 µM 0.612212157629914 0.240496593670513 no 837 0.27019869943377 1270 6498326 SGTC_3293 9120939 62.045 µM 0.612090193946053 0.240535626695817 no 838 0.270239042529178 1343 934087 SGTC_1141 3253-0389 52.6 µM 0.611151969351647 0.240836009611096 no 839 0.270549488733105 1302 5402031 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.610821957533463 0.240941715019882 no 840 0.270658727651535 1342 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1661 st013063 9.66 µM 0.608395689931253 0.241719642037719 no 841 0.271462534693678 1358 721395 SGTC_3201 9113999 49.47 µM 0.60803032436615 0.241836906111755 no 842 0.271583680924226 1382 16649224 SGTC_1938 st074717 56.4 µM 0.607932905717789 0.241868177837493 no 843 0.271615987096316 1252 17250979 SGTC_328 k915-0120 63.5 µM 0.607751949550728 0.241926271220156 no 844 0.271676001229559 1343 6624543 SGTC_1696 st025591 34.7925 µM 0.607118213601719 0.242129782719769 no 845 0.271886231856269 1338 2787147 SGTC_1226 3909-7979 35.4 µM 0.606551368022238 0.242311892340711 no 846 0.272074341338704 1365 6615510 SGTC_1103 duloxetine 36.1 µM 0.605397261407913 0.242682899719263 no 847 0.272457535123288 1426 60835 A selective serotonin reuptake inhibitor. SGTC_1607 st000305 50.6 µM 0.605179072818185 0.242753074735954 no 848 0.27253000959331 1380 5457690 SGTC_1559 coumarin 343 70.1 µM 0.603935886731539 0.243153124593498 no 849 0.272943134233949 1381 108770 A hepatotoxic, DNA x-linker. SGTC_562 3772-2733 112 µM 0.603799672556182 0.243196979159508 no 850 0.272988418596913 1340 2876874 YIL048W NEO1 SGTC_14 0354-0009 295 µM 0.603362503415598 0.243337755967541 no 851 0.273133780507299 1370 1713507 SGTC_1906 st060206 94.7 µM 0.602017554023241 0.243771131361065 no 852 0.273581226323053 1324 5133468 SGTC_2463 5473429 200 µM 0.600689311889706 0.24419953182888 no 853 0.274023469580584 1346 5399405 SGTC_1440 4100-1550 40 µM 0.595837818056993 0.245767736503635 no 854 0.275641788416481 1352 742806 SGTC_1057 3448-5381 134 µM 0.595089777205716 0.246010014610561 no 855 0.275891730812426 1375 5497911 SGTC_254 nsc-64875 3.808 µM 0.594636090926085 0.246157018523544 no 856 0.276043374931115 1457 56993 SGTC_2384 9036245 200 µM 0.594004395845649 0.2463617794746 no 857 0.276254586428821 1407 6462766 SGTC_1762 st045503 25.4615 µM 0.593616870645982 0.246487439089489 no 858 0.276384197318637 1358 4645554 SGTC_2954 9074818 52.69 µM 0.592935365088279 0.246708508577923 no 859 0.276612204604606 1387 16648742 SGTC_789 1309-1135 70.6 µM 0.592142912584326 0.24696570092512 no 860 0.276877446628348 1339 3092424 SGTC_1175 0741-0056 27.6 µM 0.591577402924548 0.247149326119788 no 861 0.277066804667916 1435 765927 SGTC_959 1222-0044 107 µM 0.591185190724952 0.247276723211201 no 862 0.277198172144697 1348 6083612 SGTC_3193 9111931 49.47 µM 0.590041948469272 0.247648267678743 no 863 0.27758126324688 1393 17087244 SGTC_1610 st001799 48.1 µM 0.589329539121477 0.247879945648563 no 864 0.277820116530572 1304 621897 SGTC_143 4032-1194 15.74 µM 0.588442463896157 0.248168587192849 no 865 0.2781176711704 1371 1806963 SGTC_2443 5493264 126.67 µM 0.588391869386481 0.248185055321858 no 866 0.278134646942411 1399 5340055 SGTC_2831 7999036 19.48 µM 0.587603780331013 0.248441647554278 no 867 0.278399136514855 1473 2988270 SGTC_2337 9009472 200 µM 0.585539245953915 0.249114504638939 no 868 0.279092592851569 1443 5742383 SGTC_3272 9137413 49.47 µM 0.585413566016045 0.249155496551076 no 869 0.279134834584102 1294 17614870 SGTC_1552 6-methylflavone 10.6 µM 0.585342676642877 0.249178619492438 no 870 0.279158662271289 1335 689013 SGTC_1309 pyrazolanthrone 13.4 µM 0.584069456661386 0.249594117058407 no 871 0.279586791556985 1424 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_895 0964-0006 13.7 µM 0.581938407439999 0.250290377935196 no 872 0.280304084467214 1336 6738897 SGTC_370 0180-0345 38.7 µM 0.58111790124058 0.250558729763308 no 873 0.280580497271838 1333 3989527 SGTC_2933 9026794 32.47 µM 0.580677989016908 0.250702668631892 no 874 0.280728749558998 1414 17586027 SGTC_275 trichlorophene 5.69 µM 0.579742116023843 0.251009031019093 no 875 0.281044268705439 1408 62616 SGTC_880 0833-0487 87.2 µM 0.578790078155784 0.251320888195974 no 876 0.281365413356329 1327 76075 SGTC_2658 polymyxin b sulfate 77.05 µM 0.577548805557124 0.251727796859082 no 877 0.281784389463097 1352 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2789 5281112 71.43 µM 0.576574601193189 0.252047399865505 no 878 0.282113430487273 1342 765948 SGTC_1403 3909-7815 62.9 µM 0.576233252528437 0.25215943527111 no 879 0.282228765973427 1383 6615483 SGTC_2335 9018011 154.17 µM 0.576099853253317 0.25220322591586 no 880 0.282273845321051 1431 6458208 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.576017232490839 0.252230349636912 no 881 0.282301766925854 1391 5379071 SGTC_1087 pterostilbene 9.05 µM 0.574176964157911 0.252834893176135 no 882 0.282924027982054 1467 5281727 Similar to reservatol, lowers cholesterol. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.573762518430119 0.252971147223221 no 883 0.283064257832028 1455 1377 SGTC_695 3505-6186 243 µM 0.573690831138284 0.252994719206887 no 884 0.283088516980652 1408 1819379 SGTC_576 1073-0113 22.7 µM 0.573441822631282 0.253076606358274 no 885 0.283172789797858 1484 5439563 SGTC_3153 9100258 49.47 µM 0.572769149289722 0.253297886577605 no 886 0.283400505137904 1329 25236848 SGTC_3096 9117468 49.47 µM 0.570282953277496 0.254116618641718 no 887 0.284242900449369 1306 41316311 SGTC_365 0121-0052 13.6 µM 0.567382541850421 0.255073507780643 no 888 0.285227154218895 1411 3101739 SGTC_739 1486-1183 203 µM 0.567355744249952 0.255082357489268 no 889 0.285236255543312 1402 4346692 SGTC_1288 0973-0013 65.5 µM 0.566996090682569 0.255201145950466 no 890 0.28535841881686 1432 4315430 SGTC_22 0964-0034 14.468 µM 0.566467013795929 0.25537594508583 no 891 0.285538175270142 1345 138402 SGTC_1037 k284-1091 78.7 µM 0.566353726881367 0.255413381529721 no 892 0.285576672057027 1358 3334711 SGTC_2137 5261020 140 µM 0.564028786587951 0.256182307028482 no 893 0.286367270651145 1351 763655 SGTC_2915 7971052 15.16 µM 0.563160688567446 0.256469721511587 no 894 0.286662734522434 1274 5741558 SGTC_1866 st057638 64 µM 0.56305458870721 0.256504861132001 no 895 0.28669885634148 1395 688802 SGTC_992 3909-8734 162 µM 0.560140984880849 0.257470808019155 no 896 0.287691638447348 1383 4288319 SGTC_2093 5331342 194.4 µM 0.559936891290903 0.257538541905244 no 897 0.287761242188801 1425 33839 SGTC_3049 9092223 49.47 µM 0.559365246423959 0.257728306710913 no 898 0.287956237348185 1385 8623917 SGTC_3281 9140613 49.47 µM 0.559267349933001 0.257760811977961 no 899 0.287989637311833 1299 16013766 SGTC_3071 9117417 49.47 µM 0.558859196869293 0.257896356864891 no 900 0.288128909171841 1382 45595590 YGL055W OLE1 SGTC_2783 7738165 71.43 µM 0.556573104113052 0.258656236001617 no 901 0.288909567117211 1329 17201110 SGTC_3142 9086498 49.47 µM 0.556501628330346 0.258680012659084 no 902 0.288933990799215 1345 25236367 SGTC_3061 glucosamine 200 µM 0.555616703802262 0.25897447944701 no 903 0.289236454994734 1375 91431 and experimental redox chemotherapeutic SGTC_222 nsc-310342 10.666 µM 0.554286253626279 0.25941752505944 no 904 0.289691478230843 1411 432556 SGTC_2018 5133068 143 µM 0.553333667049298 0.259734980824047 no 905 0.290017475727326 1407 785362 SGTC_2010 4012422 159 µM 0.553068201040455 0.259823484831261 no 906 0.290108355061959 1451 952393 SGTC_228 caffeine 993.056 µM 0.552678076438166 0.25995357713473 no 907 0.290241934092235 1425 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1799 st045822 46.1415 µM 0.550699867813988 0.260613754129548 no 908 0.290919717630108 1424 3674992 SGTC_2324 6149169 200 µM 0.550634725232489 0.260635508483751 no 909 0.290942049675499 1358 2888231 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.550384921950823 0.260718938911538 no 910 0.29102769414629 1371 6708760 SGTC_2935 9038016 29.96 µM 0.550104030632228 0.260812768674471 no 911 0.291124011142988 1390 6463195 SGTC_849 0386-0493 241 µM 0.550058380210293 0.260828019516723 no 912 0.29113966597541 1370 726119 SGTC_2313 7726885 200 µM 0.54864744175555 0.261299610374622 no 913 0.29162371075933 1411 726423 SGTC_471 1-acyl-paf 4 µM 0.546849136505223 0.261901308664985 no 914 0.292241191112413 1348 16759367 SGTC_1164 k060-0068 93.7 µM 0.546210547469797 0.262115146178417 no 915 0.292460608354283 1441 5963676 SGTC_1579 chlormadinone acetate 49.4 µM 0.545090062019214 0.262490567330728 no 916 0.292845788683008 1500 45114258 A steroidal progestin. SGTC_3181 9108277 49.47 µM 0.537936722411176 0.264893780606263 no 917 0.295310367453331 1365 17097298 SGTC_2061 5245884 80.95 µM 0.537274713511885 0.265116751037192 no 918 0.295538934708119 1414 573863 SGTC_1725 st036284 20.55 µM 0.537268821073036 0.265118736090453 no 919 0.295540969515108 1575 707914 SGTC_1334 1486-0610 236 µM 0.537023516145441 0.265201381464925 no 920 0.29562568517752 1454 3742339 SGTC_2742 clothiapine 36.27 µM 0.534954668684551 0.265898914282903 no 921 0.296340601950947 1466 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1347 1493-0251 600 nM 0.534043060337324 0.266206567044732 no 922 0.296655871308881 1475 3986378 SGTC_2433 5607874 27.82 µM 0.531152351695641 0.267183323713356 no 923 0.297656604313356 1400 2252428 SGTC_5 0352-0601 109.883 µM 0.531147157825536 0.26718508032398 no 924 0.297658403762416 1400 762456 SGTC_1400 3771-8998 51.5 µM 0.530217566044149 0.267499569953 no 925 0.29798054661906 1459 670767 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.529327499237354 0.267800862738763 no 926 0.298289141236714 1438 616764 SGTC_3125 9127534 49.47 µM 0.529090059450593 0.26788126636401 no 927 0.298371488445451 1379 1639235 SGTC_2022 5136654 200 µM 0.52662251512371 0.268717563660572 no 928 0.299227876740676 1462 1713771 SGTC_2697 mebhydrolin 72.4 µM 0.525280583188791 0.269172919679764 no 929 0.299694076632049 1549 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_838 0109-0203 71.4 µM 0.523642386224069 0.26972933117828 no 930 0.300263647358455 1436 759422 SGTC_708 3448-5400 146 µM 0.522798012697391 0.270016346365106 no 931 0.300557411357459 1430 3462195 SGTC_1677 st019204 53.9 µM 0.522787900679967 0.270019784516847 no 932 0.300560930191828 1405 3945625 SGTC_1996 st072960 66.8 µM 0.521771179090697 0.270365588264892 no 933 0.300914829374651 1439 1719405 SGTC_276 colchicine 750 µM 0.516571750869877 0.272137452635895 no 934 0.30272756989708 1483 2833 A microtubule depolymerizer. SGTC_257 daunorubicin 18.5 µM 0.516165303529116 0.272276204886425 no 935 0.302869480543842 1578 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1370 2001-0092 44.6 µM 0.516058046618169 0.27231282591592 no 936 0.302906934143685 1626 790957 SGTC_2457 5731572 11.68 µM 0.515933142006908 0.272355475533519 no 937 0.302950552848842 1578 2865357 SGTC_3139 9095020 49.47 µM 0.51375112078372 0.273101077960421 no 938 0.303713002903079 1328 25236292 SGTC_1339 1486-1321 22.7 µM 0.513139732631856 0.273310172198129 no 939 0.303926789943814 1461 3469382 SGTC_3265 9137266 49.47 µM 0.5127134192875 0.273456017910596 no 940 0.304075900683769 1527 17224265 SGTC_1430 4049-0248 69.1 µM 0.510909895159071 0.274073446039381 no 941 0.304707075997972 1553 22774488 SGTC_2084 5306078 60.6385 µM 0.510464950930693 0.274225876495167 no 942 0.304862881676994 1485 679340 SGTC_2997 9067075 71.4286 µM 0.509005426338222 0.274726178950458 no 943 0.305374210289032 1516 27209819 SGTC_2657 nystatin 74.44 µM 0.507833067707833 0.27512837103643 no 944 0.305785208672333 1503 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1351 1496-0003 46.5 µM 0.506707617201221 0.275514743298761 no 945 0.306179992566667 1508 3891978 SGTC_3315 9136395 68.55 µM 0.505573447430931 0.27590437871439 no 946 0.306578062813796 1524 16876844 SGTC_1908 st060353 56.5 µM 0.505493933753991 0.275931705184962 no 947 0.306605979046983 1632 4227716 SGTC_2594 a-mangostin 100 µM 0.505124688044564 0.276058621300607 no 948 0.306735631186535 1571 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2483 5729050 27.16 µM 0.505063141682787 0.276079778632688 no 949 0.306757244127977 1595 2865180 SGTC_1256 0570-0116 285 µM 0.50403479728899 0.276433402616218 no 950 0.307118462255049 1445 410638 SGTC_3327 9140648 26.9345 µM 0.502743224982106 0.27687785908508 no 951 0.307572407581446 1531 8029710 SGTC_2155 5570423 76 µM 0.502694223184506 0.276894728494676 no 952 0.307589635916102 1479 797402 SGTC_2756 carbadox 75.1 µM 0.501656902785549 0.277251955541575 no 953 0.307954442539003 1456 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2583 asiatic acid 100 µM 0.501454306310906 0.277321750973807 no 954 0.308025714189839 1488 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_856 0433-0016 11.3 µM 0.500539756149571 0.277636924672478 no 955 0.308347534950122 1483 3911780 SGTC_1217 1183-1422 255 µM 0.500414986462589 0.277679936557018 no 956 0.308391451542201 1568 2849664 SGTC_2129 girgensonine 121.053 µM 0.500236375743364 0.277741514737765 no 957 0.308454323941021 1562 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2750 bromebric acid 70.15 µM 0.499928179472263 0.277847784765657 no 958 0.308562824697541 1535 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2220 6782180 200 µM 0.497711435570718 0.278612730822524 no 959 0.309343723369477 1479 833803 SGTC_3221 9128209 49.47 µM 0.497506525747008 0.278683492121424 no 960 0.309415951104568 1501 16460723 SGTC_1828 st055811 49 µM 0.496860219286315 0.278906737773885 no 961 0.309643812969409 1507 5877589 SGTC_2 0422-0095 29 µM 0.496627894750994 0.278987008020872 no 962 0.309725739214248 1394 6790840 SGTC_2387 9077560 195.08 µM 0.496540364920153 0.279017253290178 no 963 0.309756607929719 1434 5303272 SGTC_927 2425-1185 123 µM 0.495629936984235 0.279331939282173 no 964 0.310077763597032 1440 730375 SGTC_1210 3013-0140 750 nM 0.495498961356685 0.279377224699236 no 965 0.310123977499002 1608 905973 SGTC_1859 st055998 20 µM 0.494943775172183 0.279569222429826 no 966 0.31031990464389 1624 676301 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.49475484293839 0.279634574684669 no 967 0.310386591771553 1558 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_958 1222-0007 33 µM 0.494728698304309 0.27964361877997 no 968 0.31039582049495 1577 7312461 SGTC_2700 st077718 96.8 µM 0.494295887004069 0.279793359865766 no 969 0.310548614721844 1482 904970 SGTC_2270 7924575 90.91 µM 0.491737272908322 0.280679365425723 no 970 0.311452542628828 1622 1262135 SGTC_1061 3448-9325 110 µM 0.490833951727714 0.280992494385475 no 971 0.311771947292326 1476 723482 SGTC_563 tetrahydrosecaminediol 614 µM 0.490618286741161 0.281067277858176 no 972 0.311848225067882 1600 334274 A psychoactive constituent of the cannabis plant. SGTC_140 0062-0056 502.533 µM 0.490254383120041 0.281193486000068 no 973 0.311976951132802 1397 3758964 SGTC_851 0394-0702 453 µM 0.490102919668755 0.281246024239432 no 974 0.312030536083663 1576 762646 SGTC_2447 5741742 33.78 µM 0.489933062804872 0.281304948252737 no 975 0.312090633013455 1568 1776504 SGTC_813 k007-0158 173 µM 0.489442499474548 0.28147516005144 no 976 0.312264226934077 1600 6523916 SGTC_738 1315-0003 72.4 µM 0.488186965180339 0.28191102164114 no 977 0.312708708236128 1561 6251474 SGTC_577 r071-0003 38.6 µM 0.487157483845654 0.282268650877096 no 978 0.313073366163802 1483 4568517 YMR134W ERG29 SGTC_1735 st034310 56.75 µM 0.486020295466373 0.282663949820491 no 979 0.313476388188744 1608 871153 SGTC_1896 st058441 89 µM 0.485654690544226 0.282791094526451 no 980 0.313606006715936 1446 688759 SGTC_2067 5224629 34.075 µM 0.485423008492019 0.282871679723708 no 981 0.313688157258169 1478 2835000 SGTC_420 mitomycin C 81.9 mM 0.483465895245486 0.28355285561155 no 982 0.314382484906134 1470 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1796 st049173 110.4 µM 0.483141296453 0.283665908602215 no 983 0.314497706850063 1497 94134 SGTC_2561 acetosyringone 100 µM 0.482647972941625 0.283837767262797 no 984 0.314672855144773 1463 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2903 5923464 63.88 µM 0.480495675577675 0.284588143660711 no 985 0.31543748869488 1520 2876576 SGTC_1750 st081859 2.357 µM 0.478841859302681 0.285165372579125 no 986 0.316025567585154 1545 5291695 SGTC_2860 9025725 38.96 µM 0.478240871687327 0.285375272492814 no 987 0.316239387654422 1467 40546248 SGTC_2523 spermine 47.74 µM 0.477928688633478 0.285484334046631 no 988 0.316350480762583 1601 1103 A DNA binding polyamine. SGTC_881 0833-0569 170 µM 0.477693527904094 0.285566500853102 no 989 0.316434175740324 1457 5418700 SGTC_317 4495-0002 170 µM 0.477521869944477 0.285626486452943 no 990 0.31649527567511 1490 15991618 SGTC_801 0866-0028 10.1 µM 0.476988626894691 0.285812865618996 no 991 0.316685110147624 1526 6849771 SGTC_3173 9105693 49.47 µM 0.476666828727258 0.285925368523649 no 992 0.316799693630139 1563 17096658 SGTC_2946 9065502 71.43 µM 0.47625661377404 0.286068813074198 no 993 0.316945785383781 1418 16489101 SGTC_844 0330-0132 15.3 µM 0.476151467972384 0.286105586113012 no 994 0.316983236042397 1567 2828079 SGTC_2771 fluoxetine 41.05 µM 0.472987280105691 0.287213258789851 no 995 0.318111127048552 1556 3386 A selective serotonin reuptake inhibitor. SGTC_196 k015-0023 18.111 µM 0.472455765532231 0.287399522578877 no 996 0.318300754099892 1512 5211998 SGTC_1166 k206-0078 225 µM 0.472043040924117 0.287544197051234 no 997 0.318448033619323 1490 5404595 SGTC_822 1487-0950 154 µM 0.471929833651195 0.287583886193511 no 998 0.318488436305813 1543 1958375 SGTC_1315 1237-0019 3.69 µM 0.471436567300006 0.287756849809048 no 999 0.318664503944575 1592 825140 SGTC_3133 9127736 49.47 µM 0.470554365392383 0.28806631598879 no 1000 0.318979501231836 1596 27243420 SGTC_2582 agaric acid 100 µM 0.470527689923276 0.288075675879424 no 1001 0.318989027960775 1426 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_57 miconazole 162.5 nM 0.470184975957413 0.288195940146985 no 1002 0.319111433558675 1455 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2856 9022925 19.48 µM 0.469852131613821 0.28831276365955 no 1003 0.319230332950276 1541 4944862 SGTC_2006 4011487 200 µM 0.467185215976831 0.28924961747701 no 1004 0.320183685005363 1652 45595294 SGTC_3186 9110464 49.47 µM 0.466990411753003 0.289318105783641 no 1005 0.320253369025593 1568 17018021 SGTC_1695 st026914 34.495 µM 0.466963281039544 0.289327644870392 no 1006 0.320263074539843 1496 3289191 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.465896523291145 0.289702831155666 no 1007 0.320644784933189 1524 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_168 3970-0862 530.542 µM 0.465494557497022 0.289844264588053 no 1008 0.3207886667562 1548 3135186 SGTC_653 0203-0016 55.2 µM 0.465166078153932 0.289959865532338 no 1009 0.32090626443114 1567 295302 SGTC_1946 st076057 65.1 µM 0.462796251116246 0.290794512966522 no 1010 0.321755209322534 1470 953009 SGTC_98 0074-0023 107.663 µM 0.462715268210492 0.290823054790734 no 1011 0.32178423637133 1480 3563821 SGTC_1829 berberine 14.4 µM 0.460242237708533 0.291695286006874 no 1012 0.322671178332956 1626 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_120 rhodamine 6G 52.259 µM 0.459288839055746 0.292031872476444 no 1013 0.323013380738643 1512 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3 0833-0587 95.581 µM 0.45871921609057 0.292233057582634 no 1014 0.323217906468271 1515 5382644 SGTC_3269 9137823 49.47 µM 0.458518536774487 0.292303950856119 no 1015 0.323289974028832 1515 17682936 SGTC_1498 4478-3555 97.6 µM 0.458018755538725 0.292480541565265 no 1016 0.323469483300035 1567 3437919 SGTC_2701 st077767 14.721 µM 0.457425018071241 0.292690394818395 no 1017 0.323682792773881 1517 5721188 SGTC_3002 9075603 71.4286 µM 0.457332404663579 0.292723134823669 no 1018 0.323716070814749 1524 20105405 SGTC_80 0159-0065 512.242 µM 0.456314066961344 0.293083242132037 no 1019 0.324082074927876 1545 1548079 SGTC_2605 digitonin 300 nM 0.45619295234234 0.293126084677006 no 1020 0.324125616457885 1601 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2189 6047310 154.431 µM 0.452604415701042 0.294396793367591 no 1021 0.325416809277614 1512 711535 SGTC_2371 9071574 200 µM 0.452601098312202 0.294397969238011 no 1022 0.325418003881696 1541 45596039 SGTC_2186 6124449 200 µM 0.450989562785655 0.294969444857231 no 1023 0.325998535703159 1585 3834182 YLR033W RSC58 SGTC_2570 licareol 100 µM 0.450206819750468 0.29524720203541 no 1024 0.326280659661729 1522 443158 SGTC_2994 9053520 71.4286 µM 0.449936106224806 0.295343293021722 no 1025 0.326378256047758 1660 4647384 SGTC_2078 5212016 200 µM 0.447274531232403 0.29628879633181 no 1026 0.327338426856103 1625 1899708 SGTC_148 3253-0744 288.01 µM 0.446575306650453 0.296537420336841 no 1027 0.327590864052309 1519 6893655 SGTC_637 1181-0519 7.26 µM 0.44572244790776 0.296840801530719 no 1028 0.327898873656633 1545 6252091 YGR060W ERG25 SGTC_1721 st082152 9.2685 µM 0.445073681591484 0.297071677508464 no 1029 0.328133253794767 1499 5296051 SGTC_1124 fisetin 1.16336 µM 0.441731998128187 0.298262178524456 no 1030 0.329341575969298 1542 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_831 k061-1017 217 µM 0.441697814873339 0.298274367795317 no 1031 0.329353945562961 1644 1240153 SGTC_742 0kpi-0133 140 µM 0.441692581129435 0.298276234095257 no 1032 0.329355839468304 1670 2728852 SGTC_900 1112-0045 141 µM 0.440750015793544 0.298612429989346 no 1033 0.329696991615998 1499 56211 YIL048W NEO1 SGTC_2368 9071271 200 µM 0.440136766741031 0.298831257250579 no 1034 0.329919027143269 1527 27209959 SGTC_1940 st075990 51.1 µM 0.439328626574031 0.299119739246093 no 1035 0.33021171729302 1650 1084979 SGTC_3209 9113616 49.47 µM 0.437532314618048 0.299761421504126 no 1036 0.330862673030337 1769 16649353 SGTC_1170 0310-0127 64.8 µM 0.436345333040563 0.300185779271913 no 1037 0.33129309778629 1622 774975 SGTC_2874 9043904 71.43 µM 0.435598917005322 0.300452769492444 no 1038 0.331563878341599 1560 4463428 SGTC_503 tyrphostin 8 294 µM 0.434245085975671 0.30093730329255 no 1039 0.332055238059908 1653 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_952 1185-0122 232 µM 0.434215905493688 0.300947750815012 no 1040 0.332065832013956 1524 678600 SGTC_2237 6667747 47.222 µM 0.433244935555469 0.301295481543848 no 1041 0.332418418486469 1565 729940 YDL015C TSC13 SGTC_2648 atorvastatin 78.68 µM 0.43264760359357 0.301509492207725 no 1042 0.332635400231882 1656 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1408 3909-7976 48.8 µM 0.431927631924611 0.301767532797979 no 1043 0.332897005568572 1601 24152374 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.430526103054683 0.302270130583057 no 1044 0.333406491410571 1605 4213774 SGTC_345 1362-0200 395 µM 0.429396195936663 0.302675596209549 no 1045 0.333817460843905 1537 1419823 SGTC_2011 4012611 177 µM 0.429067514623567 0.302793588785568 no 1046 0.333937046164735 1537 2049887 SGTC_1961 st076550 68.7 µM 0.427207314365858 0.303461765769858 no 1047 0.334614167141653 1593 1579337 SGTC_906 1165-0455 526 µM 0.426674732242716 0.303653188494519 no 1048 0.334808128556356 1543 3252859 SGTC_217 ketoconazole 989 nM 0.426613995014521 0.303675022327424 no 1049 0.334830251286313 1540 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2848 9016370 25.97 µM 0.426415324196942 0.303746445453438 no 1050 0.33490261850093 1711 7894410 SGTC_45 0kpi-0036 14.9 µM 0.425695678316324 0.304005224381263 no 1051 0.335164805782251 1618 2795021 SGTC_3001 9076041 71.4286 µM 0.425494454313294 0.30407760050985 no 1052 0.335238131735539 1571 16004211 SGTC_1483 3453-0561 55.9 µM 0.424577345459836 0.304407562885385 no 1053 0.335572405346214 1632 4546991 SGTC_2330 7979373 200 µM 0.424431795137664 0.30445994441741 no 1054 0.335625468420383 1487 1863007 SGTC_1018 4259-0013 28.1 µM 0.423743779597168 0.304707605898148 no 1055 0.335876341624981 1610 6801262 SGTC_1924 st058459 75.1 µM 0.422370679373628 0.305202141412172 no 1056 0.336377237924021 1581 688683 SGTC_2461 5755302 26.15 µM 0.419826084744512 0.306119542430778 no 1057 0.337306253919079 1704 2788904 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.415778548561888 0.307581304667707 no 1058 0.338786028641297 1584 15053 SGTC_2709 st078560 56 µM 0.415024323436112 0.307854031035361 no 1059 0.339062048597838 1715 17250903 SGTC_2204 7233102 200 µM 0.414848320981679 0.307917688472898 no 1060 0.339126471766521 1633 2172480 SGTC_327 1273-0057 3.96 µM 0.413886761238992 0.308265572177212 no 1061 0.339478519897963 1600 3108138 SGTC_3314 9135860 59.4275 µM 0.413567372102457 0.308381162437977 no 1062 0.339595486289712 1704 25252478 SGTC_1746 st038117 42 µM 0.412855024705046 0.308639036823007 no 1063 0.339856417135135 1613 2898218 SGTC_486 niguldipine 82 µM 0.411254741736595 0.309218693764452 no 1064 0.340442875990433 1630 1236 A calcium channel blocker. SGTC_2118 5526350 200 µM 0.410898172033116 0.309347915776148 no 1065 0.340573601434642 1657 743594 SGTC_3249 9135183 49.47 µM 0.410625007444978 0.309446927459141 no 1066 0.340673761886919 1643 4902779 SGTC_2348 9022543 33.42 µM 0.4105081109619 0.309489302176725 no 1067 0.340716627408056 1643 3162678 YDL140C RPO21 SGTC_2773 thioridazine 9.09 µM 0.409427251687693 0.30988123121454 no 1068 0.341113072006366 1628 5452 An antipsychotic. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.408923906520049 0.310063822385997 no 1069 0.341297752133027 1681 688751 SGTC_3144 9087057 49.47 µM 0.408701435743349 0.31014453979041 no 1070 0.341379390008733 1772 17249618 SGTC_2321 7390090 138.78 µM 0.405932758097703 0.311149842751633 no 1071 0.342396003923649 1537 649046 SGTC_460 trequinsin 123 µM 0.405407854083552 0.311340593940653 no 1072 0.342588869350263 1631 5537 A vasodilator. SGTC_3054 9094397 49.47 µM 0.405078488794174 0.311460311831894 no 1073 0.342709908964925 1547 2598354 SGTC_935 2996-0153 430 µM 0.403510442235162 0.312030539569381 no 1074 0.343286377216605 1759 23738523 SGTC_1176 0848-0131 83.3 µM 0.403051379677198 0.312197565251231 no 1075 0.34345521361775 1750 6769040 SGTC_2647 atorvastatin 60.16 µM 0.401395738762691 0.312800275458264 no 1076 0.344064393104265 1679 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_157 1348-1695 65.819 µM 0.400715192626806 0.313048162974584 no 1077 0.344314911993586 1611 5380510 SGTC_543 3844-1095 191 µM 0.400569570584565 0.313101216483548 no 1078 0.344368526454261 1707 4230703 SGTC_665 3914-0008 307 µM 0.399585797780963 0.313459729205714 no 1079 0.344730809331671 1572 1069549 SGTC_1636 st007707 68.9 µM 0.398276846607554 0.313937018824013 no 1080 0.345213062765111 1748 403051 SGTC_334 1502-1024 68.5 µM 0.397431439536054 0.314245449567148 no 1081 0.34552466757031 1642 3296216 SGTC_568 1193-0097 7.48 µM 0.396879471257699 0.314446894757556 no 1082 0.345728171599899 1631 3646150 SGTC_1368 1852-0141 284 µM 0.396203531218658 0.31469365969431 no 1083 0.345977443244032 1637 2838987 SGTC_479 n-linoleoylglycine 10 µM 0.394511915371188 0.315311579290209 no 1084 0.346601565938881 1630 6433346 An anti-infammatory. SGTC_1785 bathophenanthroline 24 µM 0.390973394109207 0.316605813525447 no 1085 0.347908451073995 1582 72812 An iron chelator. SGTC_3119 9125183 49.47 µM 0.389156383480988 0.317271270325244 no 1086 0.348580233125049 1677 22695334 SGTC_1423 4048-0112 5.59 µM 0.389137069783282 0.317278346897925 no 1087 0.348587376307863 1726 X1423 SGTC_676 falcarinol 140 µM 0.388538591692134 0.317497663415399 no 1088 0.348808750388445 1763 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_101 0490-5701 117.494 µM 0.387662437939354 0.317818851692628 no 1089 0.349132928154901 1738 4661669 SGTC_1720 st037298 9.481 µM 0.387544556919966 0.317862076041691 no 1090 0.349176552660008 1620 597396 SGTC_383 2324-0395 7.37 µM 0.385340140173601 0.318670843289004 no 1091 0.34999271288427 1721 3146421 SGTC_743 1275-0778 158 µM 0.385085327575922 0.318764386001384 no 1092 0.350087099134031 1750 2849257 YMR203W TOM40 SGTC_1476 4112-3294 3.34 µM 0.384347111042966 0.31903545338633 no 1093 0.35036059741852 1745 704369 SGTC_1163 k060-0048 49.9 µM 0.384259758779896 0.319067534867512 no 1094 0.35039296527498 1653 6809982 SGTC_1895 st058434 18.3 µM 0.382347404856756 0.319770215938139 no 1095 0.351101848423742 1770 5393175 SGTC_3214 9129694 49.47 µM 0.382276165070836 0.319796405020829 no 1096 0.351128266058477 1760 17158655 SGTC_1216 1165-0504 9.65 µM 0.381056850093649 0.320244787279927 no 1097 0.351580532391334 1752 6304004 SGTC_2203 7227154 166.4 µM 0.380619182062207 0.320405796304641 no 1098 0.351742922800099 1668 896304 SGTC_1299 1079-1439 3.74 µM 0.377943106948657 0.321391003492942 no 1099 0.352736429303812 1618 323161 SGTC_3233 9132340 49.47 µM 0.377748591277883 0.321462664296214 no 1100 0.352808683503461 1600 17682950 SGTC_2644 guaiazulene 100 µM 0.377539524185077 0.321539693345029 no 1101 0.352886348849947 1728 3515 A coloring agent. SGTC_2812 7970281 58.44 µM 0.372587616381058 0.323366420319625 no 1102 0.354727695474671 1772 2233435 SGTC_539 4859-0462 2.54 µM 0.372082385939087 0.323553037150946 no 1103 0.354915755167412 1795 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_155 k072-0202 43.6 µM 0.371500548774162 0.323768005178045 no 1104 0.35513237364325 1734 5857737 SGTC_2869 9037858 32.47 µM 0.370395048183013 0.324176610085236 no 1105 0.355544081422205 1616 27187042 SGTC_2135 5326629 150.42 µM 0.368785864080953 0.324771760404149 no 1106 0.356143670998489 1632 5020077 SGTC_937 3122-0005 46.7 µM 0.367927907550118 0.32508925524671 no 1107 0.35646349520093 1791 759535 SGTC_285 1486-1325 46 µM 0.367294316850459 0.325323802984515 no 1108 0.356699746401762 1738 22310230 SGTC_153 4077-0274 519.67 µM 0.366827193101541 0.325496770966496 no 1109 0.356873961175442 1807 3121976 SGTC_1050 3232-1156 69.3 µM 0.366660899617827 0.325558355690366 no 1110 0.356935987883632 1647 700529 SGTC_1955 wogonin 32.4 µM 0.366559304804419 0.325595982409774 no 1111 0.35697388414519 1780 5281703 A flavanone. SGTC_599 1935-0052 86.5 µM 0.366504535463521 0.325616267554839 no 1112 0.356994314447523 1668 9557311 SGTC_3148 9097893 49.47 µM 0.366422244599528 0.325646746929999 no 1113 0.357025011721385 1526 17174100 SGTC_3064 1327-0027 10 µM 0.365923248441818 0.325831593026558 no 1114 0.357211173972894 1653 16000455 YPR107C YTH1 SGTC_3286 9117135 37.221 µM 0.36579265630344 0.325879976116123 no 1115 0.357259900055526 1606 3438150 SGTC_2744 captopril 92.04 µM 0.365791344003872 0.325880462324955 no 1116 0.357260389707972 1793 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1123 mangostin 811.285 nM 0.365564334113292 0.325964574263479 no 1117 0.357345096425766 1646 5281650 An antioxidant. SGTC_1258 0671-0043 57.1 µM 0.365187835729202 0.326104094357127 no 1118 0.357485598938841 1638 4298767 SGTC_2315 7733312 200 µM 0.360944689461958 0.327678168716181 no 1119 0.359070397483694 1643 726316 SGTC_3047 9092122 49.47 µM 0.360374336226115 0.32788998636996 no 1120 0.35928360793107 1640 17173831 SGTC_223 busulfan 5 mM 0.357618782915362 0.328914122196053 no 1121 0.360314309997035 1742 2478 A DNA alkylator. SGTC_948 3448-0295 75.3 µM 0.356945562607683 0.329164528676596 no 1122 0.360566279687058 1648 678569 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.356471734773803 0.329340816454694 no 1123 0.360743658026915 1638 688669 SGTC_1634 st006576 41 µM 0.356362643114354 0.329381409412222 no 1124 0.360784500939238 1833 3915356 SGTC_565 1418-0001 44.5 µM 0.356281196696871 0.329411716898798 no 1125 0.360814994762926 1763 2862145 SGTC_820 1582-0060 59.9 µM 0.355631139670973 0.329653653447229 no 1126 0.361058410089144 1657 3848840 SGTC_2544 sphondin 68.51 µM 0.355045090678637 0.329871828774651 no 1127 0.361277905704561 1777 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2540 epiandrosterone 100 µM 0.353596324417212 0.330411426292764 no 1128 0.361820714660566 1702 441302 A steroid. SGTC_1753 st043925 64 µM 0.35294222914323 0.330655161786477 no 1129 0.362065875597406 1818 670181 SGTC_2258 7960471 200 µM 0.352435411665176 0.330844066557406 no 1130 0.362255874384864 1678 2974708 SGTC_2941 9056145 11.23 µM 0.352035167032912 0.330993279155554 no 1131 0.362405944489964 1722 2119517 SGTC_2411 st077133 39.94 µM 0.351432431328178 0.331218031787573 no 1132 0.362631977696675 1842 1403142 YNL221C POP1 SGTC_1059 3448-6867 171 µM 0.350157275150952 0.331693721988443 no 1133 0.363110334466696 1832 3934407 SGTC_2205 7238770 200 µM 0.348064538820146 0.332474994319556 no 1134 0.363895857540311 1789 279867 SGTC_1002 4049-0206 172 µM 0.345818652247892 0.333314251874695 no 1135 0.364739503289875 1660 4662749 SGTC_1687 st020778 55.3625 µM 0.345397024657857 0.333471901666006 no 1136 0.364897956842599 1733 4259299 SGTC_1935 st074532 41.6 µM 0.344476174638163 0.33381631680337 no 1137 0.365244105381012 1872 2829742 SGTC_2876 9059903 25.97 µM 0.343103721592763 0.334329899791109 no 1138 0.365760215728929 1711 6916095 SGTC_1944 st076371 56.9 µM 0.342551328859453 0.334536697228625 no 1139 0.365968011424931 1650 24208455 SGTC_3208 9114115 49.47 µM 0.341859113512302 0.334795910474073 no 1140 0.366228460237486 1609 650895 SGTC_2710 st078562 53.7235 µM 0.341705002075956 0.334853631162745 no 1141 0.366286453679288 1663 17250908 SGTC_237 nikkomycin 200 µM 0.341604007103027 0.334891459799537 no 1142 0.366324460601583 1801 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3122 9126309 49.47 µM 0.339729959873893 0.335593705798361 no 1143 0.367029948773357 1838 17591206 SGTC_2121 5257820 149.641 µM 0.339101666207099 0.335829269759099 no 1144 0.367266571637847 1853 791256 SGTC_2002 4023503 131 µM 0.338589544450646 0.336021325519229 no 1145 0.367459480080768 1905 4736863 YCR052W RSC6 SGTC_1279 0874-0590 65.2 µM 0.336896270796169 0.336656641153581 no 1146 0.368097548318295 1754 3523074 SGTC_3062 9077494 49.47 µM 0.331102516100985 0.3388339752354 no 1147 0.370283525579044 1799 16459633 SGTC_3014 9081533 49.47 µM 0.330737561211978 0.338971309271229 no 1148 0.37042136386816 1850 21367265 SGTC_3100 9120536 49.47 µM 0.327492217767312 0.340193485025672 no 1149 0.37164781403426 1841 16421196 SGTC_274 sirtinol 40.1 µM 0.327296336529906 0.34026730657091 no 1150 0.371721881509329 1678 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1364 1653-0028 37.6 µM 0.327213680096035 0.34029845904666 no 1151 0.371753137348504 1734 5718652 SGTC_1870 st057514 26.5 µM 0.326677668237264 0.340500503599179 no 1152 0.371955846257591 1716 5393161 SGTC_1469 k284-2957 126 µM 0.326390822315005 0.340608646241158 no 1153 0.372064340203399 1778 23884841 SGTC_1389 3405-0187 19 µM 0.326266077542977 0.340655679861322 no 1154 0.372111525680833 1691 799890 SGTC_2665 lovastatin 100 µM 0.325774733354917 0.340840959781528 no 1155 0.372297398315936 1748 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2086 5274770 176.623 µM 0.325173267255471 0.341067817605881 no 1156 0.372524969927436 1730 689278 SGTC_991 3996-0057 64.7 µM 0.32349538927329 0.341700974360132 no 1157 0.373160049404472 1746 715343 SGTC_255 tunicamycin 200.472 nM 0.323116314066206 0.341844082308853 no 1158 0.373303577778712 1867 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3099 9120367 49.47 µM 0.322677810693637 0.342009653849355 no 1159 0.373469629233031 1735 24824940 SGTC_1930 st074634 34.3 µM 0.322155271068814 0.342206995751137 no 1160 0.373667534024054 1663 684253 YOR116C RPO31 SGTC_1480 1070-0044 41.2 µM 0.321883689384801 0.34230957810065 no 1161 0.373770405062237 1828 3124987 SGTC_2571 chrysanthemic acid 100 µM 0.321547501662682 0.342436579682557 no 1162 0.37389776034733 1667 2743 An insecticide. SGTC_135 0933-0004 26.348 µM 0.320055731722225 0.343000340150663 no 1163 0.374463041441056 1690 21230617 YGL099W LSG1 SGTC_3050 9093513 49.47 µM 0.31980577597948 0.343094836118008 no 1164 0.374557784396659 1724 25236664 SGTC_1343 1487-0095 224 µM 0.319379798359307 0.343255899906299 no 1165 0.374719263944402 1871 4560101 YGL055W OLE1 SGTC_201 4262-0159 12.803 µM 0.318848997701708 0.343456637537019 no 1166 0.374920510539639 1876 1341029 SGTC_1808 st050063 61.5 µM 0.318038803317861 0.343763121126957 no 1167 0.375227751517013 1836 4011993 SGTC_1035 k081-0041 55.2 µM 0.317485123802632 0.343972628334379 no 1168 0.375437762777271 1874 731709 SGTC_1417 3966-0327 90.4 µM 0.31586944938953 0.34458425828323 no 1169 0.376050800737134 1774 651118 SGTC_2477 5967686 25.23 µM 0.314738200404492 0.345012746148481 no 1170 0.376480218720844 1714 776118 SGTC_782 0083-0095 30.5 µM 0.31449943356662 0.345103210281311 no 1171 0.376570873301454 1742 3591729 An indicator and reagent. SGTC_2888 9058547 12.99 µM 0.314386203575789 0.345146114027884 no 1172 0.376613866648789 1693 16476514 SGTC_278 4092-0821 23.9 µM 0.308924157659234 0.347218081518145 no 1173 0.378689609931784 1827 877900 SGTC_2596 sinensetin 100 µM 0.307317478985951 0.347828431123932 no 1174 0.379300866350348 1727 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1192 1488-0095 21.4 µM 0.306912293341291 0.3479824165431 no 1175 0.379455065820946 1776 915875 SGTC_3007 9078383 71.4286 µM 0.305948504008572 0.348348792577621 no 1176 0.379821927313859 1752 6496995 SGTC_846 0335-0850 148 µM 0.304007739298292 0.349086986412278 no 1177 0.380560997471276 1806 6819598 SGTC_788 1182-0090 188 µM 0.303843346576006 0.349149541504811 no 1178 0.380623620577014 1911 5715185 SGTC_2090 5301565 104.445 µM 0.303242092814999 0.349378366852938 no 1179 0.380852686409076 1780 2056344 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.301840934075173 0.34991183265051 no 1180 0.381386662227124 1790 688788 SGTC_533 1222-0222 6.71 µM 0.300948547196423 0.350251747356772 no 1181 0.381726864989881 1895 3982874 SGTC_77 0828-0286 12.516 µM 0.298745690623012 0.351091339831734 no 1182 0.382567046015226 1815 745345 SGTC_86 0417-1630 471.922 µM 0.297289738656384 0.351646658090006 no 1183 0.383122657535475 1864 3634867 SGTC_3323 9138564 53.9225 µM 0.295847726985214 0.352196971559032 no 1184 0.383673186347482 1916 43912313 YNL103W MET4 SGTC_868 0527-0199 213 µM 0.294743393304428 0.352618626758595 no 1185 0.38409495591432 1789 2849450 SGTC_886 0866-0150 153 µM 0.293605781262008 0.353053177678874 no 1186 0.384529578796882 1927 271463 SGTC_1678 st019265 80.2 µM 0.293423230363632 0.353122927278344 no 1187 0.384599335611205 1952 5367020 SGTC_100 0086-0128 49.5915 µM 0.293417838181445 0.353124987614673 no 1188 0.384601396142425 1690 93297 SGTC_3111 9122088 49.47 µM 0.293126279324687 0.353236397771485 no 1189 0.384712815280497 1887 16876704 SGTC_1675 st018485 24.5 µM 0.293070648674356 0.353257656725125 no 1190 0.384734075600532 1773 3323024 SGTC_1333 1482-0047 286 µM 0.292838045755126 0.35334654963826 no 1191 0.384822973021391 1897 3811116 SGTC_2341 7987486 176.74 µM 0.291146292513707 0.353993320548723 no 1192 0.385469718180067 1933 1258686 SGTC_1558 st069300 45.6 µM 0.28918695269808 0.354742918708426 no 1193 0.386219157874012 1922 24208000 SGTC_2958 9077254 16.72 µM 0.287623183326276 0.355341584748864 no 1194 0.386817598360038 1791 16457351 SGTC_2820 7989630 71.43 µM 0.287516020656253 0.355382623489288 no 1195 0.386858618423058 1953 2984098 SGTC_3234 9132280 49.47 µM 0.286763301632695 0.355670930064731 no 1196 0.387146782165325 1809 17612295 SGTC_322 k048-0136 19.3 µM 0.28672501660353 0.355685596211908 no 1197 0.387161440502979 1838 6823282 SGTC_307 1501-1223 22.3 µM 0.286453162382458 0.355789743689403 no 1198 0.387265531010108 1817 2830329 SGTC_2909 7941780 10.49 µM 0.286148459078997 0.355906488459764 no 1199 0.387382208766227 1957 1243215 SGTC_2802 7925815 54.55 µM 0.284285336095225 0.356620623535319 no 1200 0.388095861428698 1768 1262923 SGTC_177 1327-0068 8.361 µM 0.284122082908207 0.356683222485176 no 1201 0.388158412157091 1812 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_687 k029-0044 34.9 µM 0.282589082361175 0.35727123510599 no 1202 0.388745925184062 1943 5829338 SGTC_1993 st073995 70.8 µM 0.282558384127466 0.357283013487225 no 1203 0.388757692697408 1832 3098394 SGTC_1692 fluoroquinolonic acid 71 µM 0.282194679405594 0.35742257104376 no 1204 0.388897118913393 1856 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1967 st070177 51.4 µM 0.280908312152911 0.357916317387543 no 1205 0.389390362539443 1874 5729214 SGTC_2192 5915882 198.485 µM 0.279107421499558 0.35860795258885 no 1206 0.390081193917789 1829 2876149 SGTC_681 1642-0006 26.6 µM 0.278003180786803 0.359032267789333 no 1207 0.390504958526112 1825 4446530 SGTC_1138 3761-0006 1.03 µM 0.274464613775751 0.360393166216611 no 1208 0.391863796967958 1855 12061087 SGTC_407 eburnamonine 100 µM 0.273973050776317 0.360582357013428 no 1209 0.392052665954683 1794 3195 SGTC_1071 trifluoperazine 6.31 µM 0.271945812892433 0.361362952391649 no 1210 0.392831842288755 1886 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1893 st059353 36.1 µM 0.271629519362595 0.361484794536882 no 1211 0.392953449694421 1791 3112488 SGTC_3248 9135562 49.47 µM 0.271476072700583 0.361543910104199 no 1212 0.393012450083194 1827 17650701 SGTC_2757 clomiphene 4.22 µM 0.271227976260125 0.361639496638652 no 1213 0.393107848601525 1957 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_656 4090-1979 187 µM 0.270745182000046 0.361825532236296 no 1214 0.393293511971494 1949 22330961 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.270417340370928 0.361951878401349 no 1215 0.393419600593241 1878 5393153 SGTC_1106 tegaserod maleate 11.7 µM 0.269997267014152 0.36211379153924 no 1216 0.393581178079958 1856 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2365 9042475 200 µM 0.269492345080504 0.362308441380312 no 1217 0.393775416069462 1820 6464479 SGTC_2398 5228213 48.84 µM 0.268877252278397 0.362545610726477 no 1218 0.394012071304705 2006 80771 YMR134W ERG29 SGTC_696 1560-0013 611 µM 0.268842433322235 0.362559037903632 no 1219 0.394025468972075 1887 1650269 SGTC_2182 6325192 200 µM 0.268749338706558 0.362594938658262 no 1220 0.394061290612831 1943 736248 SGTC_3247 9135149 49.47 µM 0.268415498835569 0.362723689691073 no 1221 0.394189755376558 1850 8934436 YOR116C RPO31 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.265733703576336 0.363758531781718 no 1222 0.395222152301498 1854 88881 An O-methylated flavonoid and antioxidant. SGTC_824 1304-0008 100 µM 0.263642025230844 0.364566352434066 no 1223 0.396027886188764 1848 768245 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.263594447639741 0.36458473424237 no 1224 0.396046218700014 1853 65057 A dermal irritant. YDR527W RBA50 SGTC_1008 4106-0037 6 µM 0.2633595670723 0.364675485928591 no 1225 0.396136725823418 1849 2905394 SGTC_839 0122-0028 230 µM 0.263228498410074 0.364726130716506 no 1226 0.39618723327681 1873 759448 SGTC_3217 9129673 49.47 µM 0.263030894189782 0.364802489233632 no 1227 0.396263383574575 1846 17248312 SGTC_3351 9150312 21.596 µM 0.262647870399066 0.364950513127643 no 1228 0.396410999867932 1917 4904905 SGTC_1482 3346-2049 8.48 µM 0.262614423403732 0.3649634400548 no 1229 0.396423890951344 1921 3826804 SGTC_1238 0333-0287 48.8 µM 0.261283832587029 0.365477824382178 no 1230 0.39693681668753 1830 7226 SGTC_1223 0764-0573 147 µM 0.25982451736079 0.366042249714923 no 1231 0.397499569077424 1850 1609797 SGTC_344 k064-0035 6.43 µM 0.259715930733249 0.366084259817499 no 1232 0.397541451634721 1765 5088750 SGTC_3329 9141233 27.5565 µM 0.259428002831434 0.366195661421764 no 1233 0.397652512986625 1931 4909101 YNL103W MET4 SGTC_2279 7948423 32.93 µM 0.259142817961047 0.366306012843486 no 1234 0.397762524457343 1997 1247112 SGTC_31 0508-1974 57.237 µM 0.258720843600648 0.366469314824999 no 1235 0.397925318061814 1932 6810525 SGTC_2101 5377231 179.231 µM 0.25642470701774 0.367358331328229 no 1236 0.398811456011054 1923 2844213 SGTC_1506 4226-2149 212 µM 0.255858677297178 0.367577595800393 no 1237 0.39902998173946 1865 991114 SGTC_3105 9121040 49.47 µM 0.255157127225625 0.367849417070138 no 1238 0.399300871399217 1979 41448907 SGTC_3149 9097855 49.47 µM 0.254771472634602 0.367998870277388 no 1239 0.399449804942889 1969 25236625 YMR079W SEC14 SGTC_2576 guaiol 23.12 µM 0.254081888101472 0.368266155635484 no 1240 0.399716147761498 2007 227829 SGTC_1235 benzylparaben 21.5 µM 0.25184691632868 0.369132876137568 no 1241 0.400579695909311 1874 7180 SGTC_3184 9108758 49.47 µM 0.25162321786714 0.369219662970075 no 1242 0.40066615533044 1866 902885 SGTC_3094 9117742 49.47 µM 0.251553072481225 0.369246878190872 no 1243 0.400693267513846 1901 17149698 SGTC_1822 st052468 42 µM 0.25131812973603 0.369338036766577 no 1244 0.400784079690513 1859 2873678 SGTC_2178 5812956 200 µM 0.250787418889316 0.369543981396842 no 1245 0.400989234535659 1896 5403383 SGTC_606 k015-0008 38.6 µM 0.250159647908997 0.369787638956883 no 1246 0.401231944792897 1970 1970475 SGTC_1571 st070080 73.4 µM 0.249839492616257 0.369911921382781 no 1247 0.401355738649829 1930 4315245 SGTC_963 1269-2853 151 µM 0.249586065894982 0.370010309800247 no 1248 0.401453737715193 1791 3668223 SGTC_1539 benzyladenosine 56 µM 0.247979292137963 0.37063430886661 no 1249 0.402075214480317 1866 92208 A nucleotide analog. SGTC_2641 levomentholum 100 µM 0.24665844107001 0.371147523415152 no 1250 0.402586286052782 1930 16666 SGTC_3312 9133330 71.43 µM 0.2447145866283 0.371903221624815 no 1251 0.403338716447678 1946 17617324 SGTC_1625 st003711 30.1 µM 0.244423897929006 0.372016273075486 no 1252 0.403451267547487 1942 24207034 YER133W GLC7 SGTC_977 1348-1378 135 µM 0.242235121060377 0.372867861798865 no 1253 0.40429899129495 1910 X977 SGTC_1322 1348-1070 12 µM 0.240612690506054 0.373499503273307 no 1254 0.404927656757001 1964 6758089 SGTC_2393 9031399 185.94 µM 0.240045792143829 0.373720287274184 no 1255 0.405147378603956 1955 1526623 YDL150W RPC53 SGTC_1158 4092-0494 91.8 µM 0.238834924843515 0.374192009878621 no 1256 0.405616793832524 1955 1148199 SGTC_647 0140-0236 81 µM 0.231016498923669 0.377242374291475 no 1257 0.408650992200929 1931 990837 SGTC_3317 9138495 8.753 µM 0.231005927925486 0.377246503812202 no 1258 0.408655098378677 1927 17020139 SGTC_596 1155-0152 116 µM 0.230152981004435 0.377579750544893 no 1259 0.408986448410653 1856 280313 SGTC_2619 obliquin 87.91 µM 0.229783677356763 0.37772406593307 no 1260 0.409129934478781 1958 6708593 A bioactive alkalod. YER133W GLC7 SGTC_390 dec-rvkr-cmk 16.7 µM 0.227975819259741 0.378430781344502 no 1261 0.409832519499533 1925 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1298 1079-1278 263 µM 0.227273978272667 0.378705249937207 no 1262 0.410105353011886 1898 2840950 SGTC_303 1348-1668 34.2 µM 0.226944901154513 0.378833963035541 no 1263 0.410233293374555 1931 5380509 SGTC_995 3931-2021 34.6 µM 0.224006898838672 0.379983708324461 no 1264 0.411375967569821 1918 730143 SGTC_1410 3909-8106 77.9 µM 0.223961723255909 0.380001395456774 no 1265 0.411393543558966 2000 1039210 SGTC_2630 antimycin a 100 µM 0.220790048165414 0.381243794245434 no 1266 0.412627956393182 1898 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1100 amiodarone 5.07 µM 0.220696421411014 0.381280488104948 no 1267 0.412664409032272 2065 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.220587925083919 0.381323010928706 no 1268 0.412706651932712 1996 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2761 levamisole 97.89 µM 0.220368480360877 0.381409021991456 no 1269 0.412792095533255 2017 26879 An alkaline phosphatase inhibitor. SGTC_3043 9092303 49.47 µM 0.220311497002924 0.381431357499749 no 1270 0.412814283406087 1837 25236084 SGTC_428 3448-4153 16.5 µM 0.219143657078038 0.381889197292703 no 1271 0.413269071877128 1805 3834874 SGTC_418 lividomycin a 100 µM 0.21910936370195 0.381902644163409 no 1272 0.413282428408032 2014 72394 An antibiotic. SGTC_2650 prasterone 100 µM 0.218646816703071 0.382084028664132 no 1273 0.413462590295247 1959 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3137 9097352 49.47 µM 0.218223706273097 0.38224997106507 no 1274 0.413627407611566 1991 44120435 SGTC_1848 st056003 16.4 µM 0.216233985759476 0.383030621905094 no 1275 0.414402681666635 2097 146492 SGTC_3026 9090633 49.47 µM 0.216193144619698 0.383046650586765 no 1276 0.414418598499423 1895 25236842 SGTC_3020 9089140 49.47 µM 0.215305232051477 0.38339517386284 no 1277 0.414764675348749 1901 17217859 SGTC_2819 7996655 46.38 µM 0.210364049127017 0.385336402813197 no 1278 0.416691774736244 2011 6456960 SGTC_520 3584-0023 682 µM 0.20856001397811 0.38604586856251 no 1279 0.417395864145666 1879 1340790 SGTC_974 1326-0144 138 µM 0.207856913754834 0.386322477383551 no 1280 0.417670346098075 1888 5411856 SGTC_692 k241-0027 77.8 µM 0.207523748414782 0.386453569170658 no 1281 0.417800423894953 2023 3600480 SGTC_3187 9109394 49.47 µM 0.204105860190422 0.387799164147787 no 1282 0.419135387482092 1899 17098090 SGTC_1783 st039459 87.517 µM 0.203765322675754 0.387933305152675 no 1283 0.419268446383006 2053 729761 SGTC_2922 7999257 32.47 µM 0.202912594658811 0.38826926156759 no 1284 0.419601674973908 1993 2988377 SGTC_3279 9140807 49.47 µM 0.201550751976177 0.388805971477516 no 1285 0.420133974602906 2049 45595718 SGTC_3039 9090270 49.47 µM 0.201535078720039 0.388812149634138 no 1286 0.420140101616929 2079 17173750 SGTC_1683 st010134 710 nM 0.200812287164881 0.38909709347963 no 1287 0.420422677434594 1861 3818134 SGTC_1623 st003709 20.3 µM 0.200739280627708 0.389125877937258 no 1288 0.420451221669796 1889 16192618 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.200006909140409 0.389414665396108 no 1289 0.420737588793885 1919 688667 SGTC_2059 5238311 157 µM 0.199954031813932 0.389435518258258 no 1290 0.420758266166838 1914 703021 SGTC_548 1436-0017 110 µM 0.199446487716837 0.389635691066673 no 1291 0.420956749465246 2053 9677137 SGTC_1654 st012436 41.8 µM 0.198503483507439 0.390007684832055 no 1292 0.421325579768404 2057 4323132 SGTC_289 k017-0060 526 µM 0.19610983007853 0.390952378542506 no 1293 0.422262101182813 1971 5512909 SGTC_1052 3253-3998 198 µM 0.194494271393707 0.391590348977622 no 1294 0.42289444042604 2047 5450317 SGTC_685 1278-0033 54.9 µM 0.194304603892558 0.391665266231508 no 1295 0.422968690475206 2033 3590572 SGTC_161 4065-0411 162.148 µM 0.192728576582979 0.392287940466322 no 1296 0.423585771064743 1971 1906281 YLR208W SEC13 SGTC_2171 5739187 198.077 µM 0.192105795592915 0.392534071781858 no 1297 0.423829667619781 1937 2262761 SGTC_3261 9137475 49.47 µM 0.191024460123175 0.392961531984974 no 1298 0.424253214804098 2081 17027690 SGTC_27 0485-0001 32.618 µM 0.190991520427608 0.392974555328156 no 1299 0.424266118295464 2074 2054479 SGTC_941 3237-0776 460 µM 0.190247385744723 0.393268795205116 no 1300 0.424557640332139 2046 760008 SGTC_1143 3454-2408 5.08 µM 0.189862061030973 0.393421181242181 no 1301 0.424708611284983 2027 X1143 SGTC_607 4491-0986 66.8 µM 0.185852658256637 0.395007761891926 no 1302 0.42628015425939 2078 698981 YDR232W HEM1 SGTC_1435 4092-0789 56.7 µM 0.185433054746351 0.395173906449674 no 1303 0.42644469201593 2075 2248285 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.185362249218305 0.395201944208666 no 1304 0.426472458020058 2005 229346 A bile salt which induces apoptosis. SGTC_346 4513-0042 7.16 µM 0.185193941555259 0.395268593296655 no 1305 0.426538460420491 1955 2827372 SGTC_983 1491-0821 12.2 µM 0.184357792378041 0.395599750045233 no 1306 0.426866389517371 2071 46495113 SGTC_51 1013-0126 23.419 µM 0.182248792566129 0.396435353463526 no 1307 0.427693741592811 2138 1627850 SGTC_2939 9044578 71.43 µM 0.18138233555714 0.396778789149948 no 1308 0.428033741546109 1978 2653634 SGTC_17 0960-0276 49.807 µM 0.181361114310183 0.396787201575368 no 1309 0.428042069489303 2063 6821114 SGTC_1770 st043884 66.3 µM 0.180402613569615 0.397167215888552 no 1310 0.428418251328185 2080 670149 SGTC_1374 2889-5571 141 µM 0.18015011620886 0.397267339129446 no 1311 0.428517359557318 1964 2853281 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.179090905697315 0.397687423510078 no 1312 0.428933161383237 2120 16623 A steroid. SGTC_580 1123-0028 41 µM 0.178551367748837 0.397901450670357 no 1313 0.429144991809376 2075 1677248 YPR107C YTH1 SGTC_2512 diallyl trisulfide 49.23 µM 0.17510646544342 0.399268717143402 no 1314 0.430497989037646 2114 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2687 chenodiol 100 µM 0.174438193665265 0.399534094982061 no 1315 0.430760550109456 2003 5702181 A cholesterol synthesis inhibitor. SGTC_1734 st037168 69.4 µM 0.173654445997537 0.399845388667704 no 1316 0.43106852014696 1919 708907 SGTC_2029 5175081 200 µM 0.173099600174735 0.400065804221014 no 1317 0.431286569611081 2064 1380876 SGTC_414 piperonyl butoxide 100 µM 0.172621295642694 0.400255838883114 no 1318 0.431474555841232 1964 5794 A potent inhibitor of cytochrome P450. SGTC_2920 7982904 15.77 µM 0.172576371815485 0.400273688734866 no 1319 0.431492212882011 1987 6456808 SGTC_3027 9089541 49.47 µM 0.172352486135837 0.400362649670398 no 1320 0.431580211845687 2000 9943819 SGTC_2978 9011784 42.97 µM 0.172171675442151 0.400434498541336 no 1321 0.431651282530741 2128 2994934 SGTC_2395 5646831 180.19 µM 0.171168280455524 0.400833279470702 no 1322 0.432045723956094 2033 6808628 SGTC_1503 4585-0012 61.3 µM 0.170907768831347 0.40093683195475 no 1323 0.432148143949727 2066 2922052 SGTC_2418 pentamidine 31.67 µM 0.169678349487572 0.401425615780026 no 1324 0.432631550878372 2132 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3341 9147222 25.867 µM 0.167767664267796 0.402185558421343 no 1325 0.43338303103438 2021 1939759 SGTC_409 arachidonic acid 100 µM 0.167759097268583 0.40218896663506 no 1326 0.433386401014051 2010 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2325 6158266 200 µM 0.167376057360686 0.402341359194843 no 1327 0.433537081437984 1995 3623240 SGTC_1742 st038235 28.8875 µM 0.16649630630984 0.402691424616288 no 1328 0.433883194870761 1999 564103 YBR002C RER2 SGTC_2493 resveratrol 26.09 µM 0.165827385033848 0.402957650118272 no 1329 0.434146397173452 2004 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2282 7944268 200 µM 0.165722786226715 0.402999283706851 no 1330 0.434187556597766 2077 2970414 SGTC_472 calcifediol 10 µM 0.165472598544373 0.403098870670256 no 1331 0.434286007850736 2025 5283731 A vitamin D metabolite. SGTC_2499 avocadenofuran 51.48 µM 0.165315109703267 0.403161562174234 no 1332 0.434347983311213 1920 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1278 0874-0585 172 µM 0.163482403772727 0.403891289125241 no 1333 0.435069313260056 2039 766306 SGTC_2294 7971431 200 µM 0.161980851029022 0.404489410610986 no 1334 0.435660466692224 2077 5741572 SGTC_197 4544-0043 41.561 µM 0.161937958512391 0.404506499501855 no 1335 0.435677355369531 2122 896523 SGTC_2855 9016525 58.44 µM 0.161929354521213 0.404509927456631 no 1336 0.435680743154812 2077 43811474 SGTC_2606 farnesol 9.78 µM 0.159211095603521 0.405593286843656 no 1337 0.436751281169787 2113 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2026 5148700 152 µM 0.156844535831333 0.406537066427436 no 1338 0.437683686338553 2031 79838 SGTC_2765 myclobutanil 7.74 µM 0.156410263210141 0.406710312676273 no 1339 0.437854823933937 2019 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1350 1495-0454 146 µM 0.155605590855028 0.407031372326351 no 1340 0.43817195888173 2106 1069057 SGTC_1292 0kpi-0043 232 µM 0.154899467198212 0.407313163092908 no 1341 0.438450286846039 2017 3333905 SGTC_887 0885-0007 9.62 µM 0.154784199332814 0.407359167272058 no 1342 0.43849572409152 2113 5719458 SGTC_2804 7954240 19.48 µM 0.154682245195576 0.407399858917879 no 1343 0.438535913896604 2113 828705 SGTC_1904 st060225 78 µM 0.153618738140253 0.407824382332952 no 1344 0.438955180709588 2125 66595 SGTC_2075 5212009 200 µM 0.153418548162084 0.407904304909171 no 1345 0.439034109359982 2126 780898 SGTC_668 1682-0499 62.6 µM 0.152223006120445 0.408381685200945 no 1346 0.439505524575143 2018 682214 SGTC_1811 st050069 61.5 µM 0.152204881685621 0.408388923341396 no 1347 0.439512671898583 2163 3877702 SGTC_1354 1498-1681 81 µM 0.151066084800956 0.408843773716898 no 1348 0.439961792914166 2024 5754243 SGTC_891 0929-0073 133 µM 0.150979919176934 0.408878194399111 no 1349 0.439995778238623 2102 5603632 SGTC_2616 abietic acid 100 µM 0.14972852962277 0.409378167528775 no 1350 0.440489399261614 2180 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1388 3346-4487 254 µM 0.148986116368293 0.409674856871016 no 1351 0.440782294112596 2079 3345614 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.148761321637853 0.409764701416435 no 1352 0.440870985913543 2155 551469 SGTC_1144 3486-0183 12.5 µM 0.148761061777916 0.409764805278365 no 1353 0.440871088441889 2044 6744069 SGTC_2157 5649910 96.377 µM 0.148519314724545 0.409861430515193 no 1354 0.440966472022929 2000 2858091 SGTC_1063 disulfiram 1.84 µM 0.147221885604097 0.410380100630568 no 1355 0.441478443301414 2142 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_947 3447-0010 211 µM 0.146688090038351 0.410593540375245 no 1356 0.441689109840723 2143 748350 SGTC_2148 5546263 113.568 µM 0.146443441150881 0.41069137281383 no 1357 0.441785667928471 2047 792097 SGTC_2285 7945142 200 µM 0.146441633725829 0.410692095604203 no 1358 0.44178638129635 2038 2970608 SGTC_3155 9099265 49.47 µM 0.146159946362182 0.410804746256987 no 1359 0.441897562053471 2090 25236499 SGTC_37 0566-0070 1.56 µM 0.14502201421781 0.411259895781259 no 1360 0.44234674534811 2120 1626686 SGTC_2759 disulfiram 3.38 µM 0.145008503214463 0.411265300624426 no 1361 0.442352079080054 2065 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1117 retinoic acid 1.10837 µM 0.14429601779561 0.411550341928575 no 1362 0.442633361369829 2151 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2386 9075165 157.42 µM 0.144173377760507 0.411599410770305 no 1363 0.442681781380067 2062 16452277 SGTC_3073 9114972 49.47 µM 0.143554392661766 0.411847090637501 no 1364 0.442926178450806 2175 41905075 SGTC_2425 5628681 7.85 µM 0.143492182065239 0.411871985446256 no 1365 0.44295074258322 2089 5714958 SGTC_2913 7966556 36.57 µM 0.143381261596461 0.411916373360125 no 1366 0.442994540570627 2142 2976516 SGTC_3081 9117243 49.47 µM 0.141671346695531 0.41260078569014 no 1367 0.443669804321427 2143 45595589 SGTC_2962 9082311 13.18 µM 0.139762536918731 0.413365121808674 no 1368 0.444423806956221 2055 16459453 SGTC_1421 4029-0249 71.4 µM 0.138694740488602 0.413792838179462 no 1369 0.444845687206286 2181 2894095 SGTC_1653 st012112 65 µM 0.138578629208113 0.41383935387121 no 1370 0.444891565882879 2150 720429 SGTC_2601 securinine 100 µM 0.138403150407831 0.41390965525884 no 1371 0.444960903657204 2047 442872 A GABA receptor antagonist. SGTC_142 0335-0849 62.6745 µM 0.138340239689366 0.413934859606715 no 1372 0.444985762279292 2135 3889043 YPR107C YTH1 SGTC_3189 9110682 49.47 µM 0.136577293635461 0.41464130444229 no 1373 0.445682462672466 2049 17122418 SGTC_1809 st050081 57.6 µM 0.13582657131333 0.414942216628211 no 1374 0.445979192424801 2132 5036894 SGTC_2346 9031566 143.75 µM 0.135823875099049 0.4149432974424 no 1375 0.445980258182384 2127 4771086 SGTC_1727 st034309 9.9045 µM 0.135498735237754 0.415073638898376 no 1376 0.446108782085026 2182 870305 SGTC_770 0389-1121 67.2 µM 0.135430252592734 0.415101093284604 no 1377 0.44613585317879 2164 6753108 SGTC_638 3970-0837 4.09 µM 0.135166054183242 0.41520701312961 no 1378 0.446240292792043 2042 4118451 YLR208W SEC13 SGTC_872 0588-0139 234 µM 0.133789808093386 0.415758863764534 no 1379 0.446784393350129 2188 2047100 SGTC_605 1315-0399 119 µM 0.133513292436685 0.415869761793714 no 1380 0.446893726270124 2113 24020461 SGTC_3251 9135047 49.47 µM 0.13333400703728 0.415941668707937 no 1381 0.44696461698588 2145 17682963 SGTC_1923 st058458 19.1 µM 0.132437642394198 0.416301220431575 no 1382 0.447319071281243 2202 3534982 SGTC_2065 5221596 34.26 µM 0.132172026606874 0.41640777827865 no 1383 0.447424113256576 2098 788581 SGTC_1833 st055984 71 µM 0.132035128997083 0.416462700285043 no 1384 0.447478253027934 2046 676288 SGTC_1074 carmofur 3.8 µM 0.131359768875285 0.416733672130103 no 1385 0.447745356308304 2168 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_985 1493-0307 8.71 µM 0.129337021508525 0.417545486612231 no 1386 0.448545489254034 2181 3278274 SGTC_1798 st045719 60.953 µM 0.127319492968155 0.418355556789313 no 1387 0.449343766350321 2174 3980186 SGTC_50 0929-0078 56.389 µM 0.126012696052323 0.418880441862067 no 1388 0.449860937346438 2126 1377751 SGTC_2532 xanthone 78.9 µM 0.125655430991877 0.419023965312675 no 1389 0.450002341528384 2152 7020 An insecticide. SGTC_1643 st009866 20.2 µM 0.125170908537104 0.419218628863021 no 1390 0.450194123852849 2185 3156273 YOR207C RET1 SGTC_1971 st069429 63.5 µM 0.123995676962227 0.41969087635321 no 1391 0.450659348966531 2193 1246522 YGL099W LSG1 SGTC_2428 5615643 7.78 µM 0.123870845710559 0.419741044547854 no 1392 0.450708768441572 2138 2253075 SGTC_234 nsc-17383 10.7 µM 0.123808576363255 0.41976607034525 no 1393 0.450733420554568 2173 408974 SGTC_2199 6590217 200 µM 0.122447626202851 0.420313111551581 no 1394 0.451272261000428 2150 703109 SGTC_725 1497-0963 19 µM 0.121798534103978 0.420574071888801 no 1395 0.451529287461684 2199 3549977 SGTC_2495 cafestol 54.53 µM 0.121736420945887 0.420599045632662 no 1396 0.451553883998652 2119 16667697 An anti-infammatory. SGTC_1995 st072814 61.1 µM 0.119004341273433 0.421697843590808 no 1397 0.452635958193406 2034 5769371 SGTC_981 1488-1094 54.9 µM 0.118917671290877 0.421732710872898 no 1398 0.4526702907202 2151 3449522 SGTC_2696 st077691 74.316 µM 0.117992368882024 0.422104997669117 no 1399 0.453036852197292 2123 757133 SGTC_600 1495-0418 41.6 µM 0.117601449199498 0.422262301494931 no 1400 0.453191728310542 2109 5377768 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.115763953935166 0.423001864726619 no 1401 0.453919809492352 2061 61125 An anti-inflammatory. SGTC_2349 9023730 187.07 µM 0.11554418458059 0.423090336694052 no 1402 0.454006900369732 2169 4126287 SGTC_2947 9072639 7.68 µM 0.115474465648214 0.423118404070745 no 1403 0.454034529265468 2110 16488146 SGTC_2549 cedrol 20.94 µM 0.111774973611415 0.424608298042852 no 1404 0.455500915658472 2226 6708665 A sedative which affects the nervous system. SGTC_1102 cgs 12066b 26.1 µM 0.11132279949877 0.424790476166971 no 1405 0.455680188193851 2121 6438352 A 5-HT1B full agonist. SGTC_949 1165-0505 146 µM 0.11063614263734 0.425067156634569 no 1406 0.455952442865054 2100 6244267 SGTC_232 clozapine 119 µM 0.109931933655302 0.425350947867668 no 1407 0.456231678312457 2201 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3097 9117246 49.47 µM 0.10976843526408 0.425416842099889 no 1408 0.456296512372605 2223 16423892 SGTC_2873 9040596 71.43 µM 0.108684762728287 0.425853643746956 no 1409 0.456726263918346 2052 6463863 SGTC_3006 9075424 71.4286 µM 0.108079903820484 0.426097487045448 no 1410 0.456966154595388 2114 7465181 SGTC_1878 temozolomide 1 mM 0.103592429549139 0.427907447428485 no 1411 0.458746397842126 2241 5394 DNA alkylating agent. SGTC_2359 9039622 200 µM 0.103583902852721 0.427910888009901 no 1412 0.458749781299943 2160 6463596 SGTC_2622 2-methoxyxanthone 59.94 µM 0.102485779252761 0.4283540342504 no 1413 0.459185549962405 2185 71034 A hepatoprotective. SGTC_2585 alliin 100 µM 0.101978643183067 0.428558718835895 no 1414 0.459386813482233 2178 87310 A garlic compound which reacts with lipids. SGTC_2305 7443522 69.23 µM 0.100634407993952 0.429101356841704 no 1415 0.459920340858499 2165 5415886 SGTC_1287 0971-0001 34.6 µM 0.10047328040945 0.429166409497771 no 1416 0.459984297311469 2161 4665869 SGTC_3116 9124943 49.47 µM 0.0998985514135666 0.42939846269177 no 1417 0.460212433201993 2069 41905195 YPL160W CDC60 SGTC_1092 toremifene 6.32 µM 0.0994823596501918 0.42956651995949 no 1418 0.460377646687621 2240 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3222 9128301 49.47 µM 0.0988156392694807 0.429835766692405 no 1419 0.460642325463733 2171 4911358 SGTC_913 3487-1245 167 µM 0.0982232188040095 0.430075035715517 no 1420 0.460877522835587 2164 4016153 SGTC_3225 9130819 49.47 µM 0.0977965290549883 0.430247384703187 no 1421 0.461046931792921 2219 4547121 SGTC_304 1310-0298 97 µM 0.0976537621374848 0.430305054240741 no 1422 0.461103616231252 2164 1550234 SGTC_2034 5197015 53.07 µM 0.0973392600780081 0.430432100037968 no 1423 0.461228489491186 2202 780676 SGTC_1615 st002656 86.5 µM 0.0952057724347175 0.431294130094278 no 1424 0.462075692538377 2248 1584458 SGTC_1463 k081-0032 34.1 µM 0.0951754977891067 0.431306364850282 no 1425 0.462087715778118 2183 977755 SGTC_2281 7943571 200 µM 0.0950410027225802 0.431360718531638 no 1426 0.462141129420822 2270 1244024 SGTC_1407 3909-7909 12.3 µM 0.0948585512810167 0.431434454968045 no 1427 0.462213589646453 2187 4411780 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.0940923644258948 0.431744129925512 no 1428 0.46251789288902 2218 5106787 A p450 inhibitor. SGTC_1267 0828-0272 9.49 µM 0.0932606852398257 0.432080322841714 no 1429 0.462848232274019 2225 745334 SGTC_2646 retinol 96.75 µM 0.093074991810881 0.432155393145791 no 1430 0.46292199241014 2212 445354 A vitamin A analog and teratogen. SGTC_2999 9069765 71.4286 µM 0.0928828101414822 0.432233089031047 no 1431 0.462998331112325 2204 2097066 SGTC_399 oxolinic acid 75 µM 0.0928436196002634 0.432248933443526 no 1432 0.463013898607543 2106 4628 A DNA gyrase inhibitor. SGTC_360 0957-0399 1.01 µM 0.0922614297369365 0.432484320820826 no 1433 0.46324516611653 2230 6752301 YPR165W RHO1 SGTC_3132 9126706 49.47 µM 0.092127858864966 0.432538328746074 no 1434 0.463298227199192 2170 850858 SGTC_40 0327-0103 19.753 µM 0.0913758298885195 0.432842426957277 no 1435 0.463596983172886 2187 409036 SGTC_2114 5491910 81.25 µM 0.0901169063308116 0.433351587243541 no 1436 0.464097157286566 2210 2849228 SGTC_1030 k029-0042 36.7 µM 0.0894647938814589 0.433615371798553 no 1437 0.464356265883299 2108 6080581 SGTC_1308 1187-1617 41.4 µM 0.0889515953602778 0.433822985389379 no 1438 0.464560189430727 2218 2882570 SGTC_2344 7990960 76.95 µM 0.0887896458408838 0.433888505585387 no 1439 0.464624543305747 2154 140813 SGTC_2269 7935389 174.42 µM 0.0876955035308513 0.43433121212886 no 1440 0.465059346759325 2251 97605 SGTC_2817 7995342 71.43 µM 0.0871617542523313 0.434547205093098 no 1441 0.465271469651175 2182 18879975 SGTC_403 arphamenine a 50 µM 0.0866581117105983 0.434751032645223 no 1442 0.465471636559859 2189 5487158 An arginine aminopeptidase inhibitor. SGTC_996 3970-0799 1.8 µM 0.0841727601055647 0.435757124232605 no 1443 0.466459537799066 2217 6615648 YGL040C HEM2 SGTC_2881 9058953 51.95 µM 0.0839242591277199 0.435857742532735 no 1444 0.466558325801919 2239 17122249 SGTC_2882 9058044 58.44 µM 0.0837010735366035 0.43594811414603 no 1445 0.466647051791845 2134 18076804 SGTC_867 0518-0118 155 µM 0.0833558162243456 0.436087921246631 no 1446 0.466784309869601 2275 6848158 SGTC_2508 celastrol 40.54 µM 0.0826924093902146 0.436356580929472 no 1447 0.467048060315411 2254 122724 Celastrol is a natural product and antioxidant. SGTC_2741 miltefosine 3.04 µM 0.0825716049511808 0.436405506233827 no 1448 0.467096090058836 2215 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2830 7992007 71.43 µM 0.0802033512822355 0.437364834873169 no 1449 0.468037762406517 2240 1952075 SGTC_2662 daunorubicin 22.37 µM 0.077953007432677 0.438276742188365 no 1450 0.468932716910493 2237 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2138 5575593 77.673 µM 0.076867167189375 0.438716875016672 no 1451 0.469364608514976 2250 762213 SGTC_3302 9125395 16.351 µM 0.0748871732351447 0.439519637486021 no 1452 0.470152241087168 2182 17599668 SGTC_3345 9148410 3.559 µM 0.0730723488931982 0.440255652702436 no 1453 0.470874272602879 2255 4903596 SGTC_2318 6029776 164 µM 0.0723683544921277 0.440541218479376 no 1454 0.471154384099067 2244 818325 SGTC_819 1013-0258 27.7 µM 0.0721366072081694 0.440635230393944 no 1455 0.471246596879627 2226 5753198 SGTC_1733 st037357 54.9 µM 0.0720486016245187 0.440670932113897 no 1456 0.471281614909137 2283 1272339 YGL099W LSG1 SGTC_495 decylubiquinone 155 µM 0.0714293428453382 0.440922163924413 no 1457 0.471528028516844 2136 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_326 k292-0812 17.5 µM 0.0702404910682468 0.44140454481566 no 1458 0.472001123341125 2279 3579357 SGTC_1199 1638-0010 4.46 µM 0.0696517056440914 0.441643478855376 no 1459 0.472235440841764 2234 3111136 SGTC_2653 dihydrofissinolide 100 µM 0.0674430012717292 0.442539978087173 no 1460 0.473114518516021 2240 6857746 SGTC_103 0844-0104 51.839 µM 0.0659764206176625 0.443135416845345 no 1461 0.473698299082198 2284 5375804 SGTC_2249 haloperidol 116.36 µM 0.0657817146845847 0.443214478072129 no 1462 0.47377580713393 2262 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1243 0416-0003 5.65 µM 0.0655404102355739 0.443312463974356 no 1463 0.473871866383773 2218 2141977 SGTC_1420 4'-methoxyflavone 42 µM 0.0653619136974176 0.443384947854041 no 1464 0.473942923836639 2291 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1901 st060216 58.6 µM 0.0644205793725549 0.443767236207861 no 1465 0.474317672045105 2301 688792 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.0630263916788004 0.444333530375745 no 1466 0.474872744287138 2237 6708739 YPR165W RHO1 SGTC_2953 9074162 66.49 µM 0.0621657867554191 0.444683149550013 no 1467 0.475215403992525 2309 16451992 SGTC_611 3453-1652 23.7 µM 0.0611100564817295 0.445112096798141 no 1468 0.475635780103485 2290 1560575 SGTC_449 xestospongin c 11.1929 µM 0.0594254022990559 0.445796711147732 no 1469 0.476306640349604 2265 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1086 cerivastatin 2.18 µM 0.0593332477319459 0.445834165852918 no 1470 0.476343339946047 2319 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_3021 9087658 49.47 µM 0.0591626101778338 0.445903519950792 no 1471 0.476411295104116 2308 25237042 SGTC_2985 9022375 71.43 µM 0.0580626445017664 0.446350630732563 no 1472 0.476849364769553 2233 4939335 SGTC_2327 6189656 200 µM 0.0555389873005419 0.447376696307672 no 1473 0.477854535246285 2290 5349088 SGTC_2111 5486399 200 µM 0.0547537293123785 0.447696037761642 no 1474 0.478167331862816 2295 689674 SGTC_1500 4488-1866 171 µM 0.0541351129467039 0.447947634828893 no 1475 0.478413758583297 2303 2900003 SGTC_2275 7947463 200 µM 0.0537736414930716 0.448094658353207 no 1476 0.478557755083624 2318 1225414 SGTC_202 3594-0513 34.79 µM 0.0537726766263635 0.448095050808973 no 1477 0.478558139453634 2315 708429 SGTC_2699 st077704 54.6 µM 0.0530169854808716 0.448402440803158 no 1478 0.478859187144638 2271 645852 SGTC_1637 st007924 17.4 µM 0.0528171819477458 0.448483719413264 no 1479 0.478938785696949 2309 683336 SGTC_1787 fluconazole 80 µM 0.0521373937035784 0.448760268453276 no 1480 0.479209608801974 2254 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_617 3770-0098 35 µM 0.0515826969279857 0.448985946679622 no 1481 0.479430603417265 2262 5962639 SGTC_2293 7624732 200 µM 0.0514297818973169 0.449048163021998 no 1482 0.479491526822999 2308 894453 SGTC_2068 5226020 147 µM 0.0511032787780344 0.449181011118897 no 1483 0.479621611660812 2282 1810509 SGTC_2553 4-methylesculetin 85.09 µM 0.050604072805707 0.449384139830555 no 1484 0.479820508677969 2306 5319502 SGTC_3318 9139014 38.6185 µM 0.0503263117214086 0.449497167565398 no 1485 0.479931178305087 2322 16643984 SGTC_3285 9112818 20.8695 µM 0.0501913612525919 0.449552083670125 no 1486 0.47998494780037 2322 17017947 YPR165W RHO1 SGTC_3262 9137218 49.47 µM 0.049629221018782 0.449780848738407 no 1487 0.480208930156214 2314 17650664 SGTC_3304 9125678 46.087 µM 0.0471310890685172 0.450797673719564 no 1488 0.481204374684344 2300 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2082 5219693 150 µM 0.0470671026338154 0.450823722653703 no 1489 0.481229873280739 2327 2834649 SGTC_912 3474-0017 2.18 µM 0.046947269041708 0.450872507584688 no 1490 0.481277627177749 2301 3360550 SGTC_459 nigericin 15.3 µM 0.0462624489264528 0.451151315932152 no 1491 0.481550534330948 2273 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2950 9072895 21.46 µM 0.0458841676941799 0.451305334550314 no 1492 0.481701286617854 2278 17332245 SGTC_680 0417-1641 114 µM 0.0455741578513996 0.451431561683758 no 1493 0.481824833405606 2293 2835990 SGTC_1411 3909-8223 150 µM 0.0448538707466075 0.451724860912638 no 1494 0.482111892810737 2338 X1411 SGTC_1504 k297-0033 30 µM 0.044283768013419 0.451957024106966 no 1495 0.482339105115054 2327 4388117 SGTC_2491 paeonol 100 µM 0.0428097518854207 0.452557364328325 no 1496 0.482926595118598 2263 11092 Increases levels of cortical cytochrome oxidase. SGTC_1765 st044815 90.4 µM 0.0424191763367327 0.452716456950545 no 1497 0.483082270800539 2251 645695 SGTC_758 0868-0029 16 µM 0.0404321720209804 0.453525937800552 no 1498 0.483874290824182 2339 762687 SGTC_1130 3454-2858 15.9 µM 0.0403808197058641 0.453546860669673 no 1499 0.483894760716612 2202 715628 YIL048W NEO1 SGTC_2663 amphotericin b 100 µM 0.0388237881567624 0.454181314978266 no 1500 0.484515439461514 2332 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_859 0439-0102 54.6 µM 0.0385159991339403 0.454306745772249 no 1501 0.484638137742281 2346 610143 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.0382079625790024 0.454432282003413 no 1502 0.484760936156592 2341 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3059 1327-0034 3 µM 0.0380892325425074 0.454480670078301 no 1503 0.484808268134062 2309 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_745 0469-0705 296 µM 0.036721947710747 0.455037951466643 no 1504 0.485353354350584 2339 3486736 SGTC_557 1315-0110 16.2 µM 0.0363159598637778 0.455203442103119 no 1505 0.485515212101467 2342 6833801 SGTC_748 act1.228 77.9 µM 0.0359479764573131 0.455353447911917 no 1506 0.485661920443429 2325 4421505 YNR035C ARC35 SGTC_1565 sinapyl alcohol 95.1 µM 0.0349471907446299 0.455761443200016 no 1507 0.48606092540135 2300 5280507 A phenol propionate derived from cinnamic acid. SGTC_401 neomycin 50 µM 0.0347135145104659 0.455856713886954 no 1508 0.486154092200915 2261 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_1239 0337-0584 35.4 µM 0.034634777085852 0.455888816005592 no 1509 0.486185485011231 2335 914301 YML130C ERO1 SGTC_2401 5128683 200 µM 0.0338344117126598 0.456215150123465 no 1510 0.486504597533924 2325 708373 SGTC_1462 k081-0014 26.5 µM 0.0331807273621905 0.456481699701533 no 1511 0.486765233498193 2338 3270634 SGTC_648 0375-0473 33.3 µM 0.0327110601404905 0.456673225638241 no 1512 0.486952501947768 2324 1713139 SGTC_1899 st063254 59.6 µM 0.0325843300431167 0.456724906722768 no 1513 0.487003033004779 2345 3093813 SGTC_1792 st045773 43.6 µM 0.0324529041338821 0.45677850355295 no 1514 0.487055436641962 2333 2919270 SGTC_2475 5812728 15.03 µM 0.0322976170533805 0.456841832226147 no 1515 0.487117354765435 2351 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_703 3875-0075 71.8 µM 0.0320956254023779 0.456924209445653 no 1516 0.487197896018916 2322 2850814 SGTC_3110 9122132 49.47 µM 0.0318909232391148 0.457007693967969 no 1517 0.48727951858271 2332 918317 SGTC_497 capsazepine 133 µM 0.0317328593964367 0.45707215909125 no 1518 0.48734254503315 2340 2733484 A calcium channel blocker. SGTC_1963 st076565 50.3 µM 0.0314652147582606 0.457181318474623 no 1519 0.487449266501174 2347 4914280 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.0312691837343598 0.457261272157046 no 1520 0.487527433101187 2353 97141 SGTC_671 0560-0003 407 µM 0.0311246951006921 0.457320204744488 no 1521 0.487585047682654 2306 3238678 SGTC_136 0097-0015 404.482 µM 0.0272958113927822 0.458882229745542 no 1522 0.489111898824847 2356 4861337 SGTC_3065 9113888 49.47 µM 0.0267413985359258 0.459108460293646 no 1523 0.489332996835357 2336 16648368 SGTC_1490 4089-0339 670 nM 0.0266345942768396 0.459152043754017 no 1524 0.489375590398697 2370 742542 SGTC_19 0279-0214 38.434 µM 0.0263132635010409 0.459283171699909 no 1525 0.489503737915431 2362 3566274 YBR002C RER2 SGTC_96 0929-0093 37.281 µM 0.0239160533411563 0.460261558704535 no 1526 0.490459784615474 2347 6991579 SGTC_827 3253-0474 693 µM 0.022947419524416 0.46065696132734 no 1527 0.490846107514967 2366 5402065 SGTC_2233 sulbentine 40.3845 µM 0.0226607655302626 0.46077398282941 no 1528 0.490960436181848 2349 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2938 9059746 27.26 µM 0.022348114442484 0.46090162106514 no 1529 0.491085134338591 2344 6471769 SGTC_714 4296-0578 26.1 µM 0.022074427609138 0.461013355646612 no 1530 0.491194292658227 2355 1589775 SGTC_2360 9040895 200 µM 0.0206791546137783 0.461583033352642 no 1531 0.491750798836585 2345 4914414 SGTC_1191 1487-1166 10.6 µM 0.0206647687022858 0.461588907406514 no 1532 0.491756536758797 2341 3955771 SGTC_2966 9084041 48.03 µM 0.0203502073265939 0.461717351166978 no 1533 0.491882002205361 2377 17741380 SGTC_2770 toltrazuril 17.5 µM 0.0198632647032036 0.461916190637117 no 1534 0.49207622493981 2363 68591 Kills coccidiodes. SGTC_380 3970-0968 6 µM 0.0197011939818837 0.461982373148379 no 1535 0.492140869152828 2363 2891601 SGTC_2088 5278280 127.392 µM 0.0185118428184043 0.462468083626742 no 1536 0.49261526499108 2357 791502 SGTC_1313 1220-0047 237 µM 0.0183750395467372 0.462523955323483 no 1537 0.492669832318588 2350 3528706 SGTC_2159 5658611 73.75 µM 0.0175738260931077 0.462851192974475 no 1538 0.492989418602144 2382 793844 SGTC_1835 st008666 49.2 µM 0.0174164970136969 0.462915453465682 no 1539 0.493052174218917 2362 690455 SGTC_2717 st081029 62.2815 µM 0.0173868456429975 0.462927564568812 no 1540 0.49306400161345 2367 5292846 SGTC_1297 1068-0111 14.1 µM 0.0156071318721876 0.463654551233266 no 1541 0.493773907982654 2373 767057 SGTC_1776 st049249 45.9 µM 0.0155805367213173 0.463665415884248 no 1542 0.493784516622872 2364 1822314 SGTC_544 k015-0020 52.4 µM 0.014800093905247 0.46398425441345 no 1543 0.494095832332288 2356 3008304 SGTC_362 0310-0100 9.03 µM 0.0126079779953576 0.464879934473051 no 1544 0.494970277762672 2372 790235 SGTC_2566 crystal violet carbinol 226 nM 0.0119080338066307 0.465165963464807 no 1545 0.495249494109645 2338 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1505 k297-0037 20.6 µM 0.0111876745672945 0.465460353766058 no 1546 0.49553685670012 2386 4089396 SGTC_71 0417-1750 47.813 µM 0.0110513932801134 0.465516050177396 no 1547 0.495591221706503 2388 6811472 SGTC_863 0466-0191 129 µM 0.0097711044357509 0.466039320613937 no 1548 0.496101955341759 2390 765160 YPR165W RHO1 SGTC_2173 5763948 167 µM 0.0083943432467945 0.466602086027015 no 1549 0.496651180891787 2386 2867177 SGTC_1429 4049-0205 9.46 µM 0.00663445368199406 0.467321556225183 no 1550 0.49735325533541 2386 22774478 SGTC_3129 9127257 49.47 µM 0.00653900340412337 0.467360580855576 no 1551 0.497391333660891 2385 837894 SGTC_146 3448-8650 53.125 µM 0.00552819113937557 0.467773868344976 no 1552 0.497794582053627 2387 2891488 YIL048W NEO1 SGTC_2805 7950783 58.44 µM 0.00456949617152564 0.46816587891232 no 1553 0.498177041121035 2394 1178958 YDL195W SEC31 SGTC_2014 4013930 200 µM 0.00429871885852475 0.468276605418084 no 1554 0.498285064577488 2401 64556 SGTC_2774 tamoxifen 10.92 µM 0.00374362856347315 0.468503601110723 no 1555 0.498506511772391 2400 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_722 3534-0461 190 µM 0.00257920459232053 0.468979807681109 no 1556 0.498971047379134 2399 658262 SGTC_337 1315-0038 354 µM 0.000995734252963505 0.469627459884964 no 1557 0.499602759572092 2400 1626437 SGTC_2238 6671620 73.2395 µM 0.000633559815272779 0.469775603520368 no 1558 0.499747246219434 2400 729941 SGTC_164 4100-3994 89.624 µM 0.000520219026605966 0.469821965235543 no 1559 0.499792462644578 2404 4615967 SGTC_619 1652-1634 108 µM 0 0.470034764532155 no 1560 0.5 2402 5400454 SGTC_2383 9036125 200 µM 0 0.470034764532155 no 1561 0.5 2405 79580 SGTC_3072 9116419 49.47 µM -0.000891946444851143 0.470399641458736 no 1562 0.499644164898477 2407 17170162 SGTC_281 1672-3440 14.9 µM -0.000949525093138545 0.470423196555549 no 1563 0.499621194350967 2397 6833000 SGTC_1068 loratadine 26.9 µM -0.00111912025281099 0.470492577569694 no 1564 0.499553535707494 2410 3957 A H1 histamine antagonist. SGTC_233 rapamycin 362 pM -0.00144635707449888 0.470626451977655 no 1565 0.499422987211605 2409 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_879 0831-1030 162 µM -0.00209879107483215 0.470893376257126 no 1566 0.499162704117224 2411 1549252 SGTC_38 0929-0051 58.268 µM -0.00330532408656226 0.47138702829622 no 1567 0.498681368872486 2416 1379719 SGTC_2867 9039098 71.43 µM -0.00341478672598325 0.471431817036294 no 1568 0.49863769984403 2413 6463460 SGTC_184 1494-0393 24.714 µM -0.00391046412357388 0.471634637472378 no 1569 0.49843995450108 2409 3090647 SGTC_853 0419-0306 21 µM -0.00432027367863169 0.471802328208035 no 1570 0.498276465528251 2414 762713 SGTC_3198 9112019 49.47 µM -0.0048331831505453 0.472012213630839 no 1571 0.498071846399162 2421 45595555 SGTC_1561 5-methoxyflavone 52.9 µM -0.0054303769339048 0.472256598454158 no 1572 0.497833603690028 2413 94525 SGTC_1673 st016611 27.3 µM -0.00591847695939726 0.472456347475061 no 1573 0.497638883089669 2425 5226799 SGTC_194 1486-1323 56.904 µM -0.00634616073670621 0.472631377574429 no 1574 0.497468265157661 2423 5178754 SGTC_2568 diosmetin 100 µM -0.00721822430293293 0.472988286974288 no 1575 0.497120370142272 2420 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_379 3970-0972 5.9 µM -0.00749180008180858 0.473100257798166 no 1576 0.497011232149541 2425 2898042 YBL034C STU1 SGTC_2807 7945238 51.95 µM -0.0078923001155254 0.473264180814266 no 1577 0.496851460480582 2427 17148797 SGTC_3052 9092717 49.47 µM -0.0096031950777183 0.473964493726534 no 1578 0.496168938340929 2444 25237534 SGTC_1784 st039334 36.3 µM -0.00971732004809045 0.474011210872181 no 1579 0.496123411189382 2431 3496984 SGTC_1522 st012842 45.6 µM -0.00994638975139799 0.474104981811892 no 1580 0.496032030016578 2423 3491067 YOR116C RPO31 SGTC_110 0850-0284 111.64 µM -0.0109805640316091 0.474528344511144 no 1581 0.495619476773961 2423 3906265 SGTC_2403 6032726 181.2 µM -0.0123562710765876 0.475091565896976 no 1582 0.495070686472258 2433 2881040 SGTC_3339 9145883 14.936 µM -0.012672302097616 0.475220957659028 no 1583 0.494944618208572 2439 2030670 SGTC_3254 9136651 49.47 µM -0.0136193813608036 0.475608733464491 no 1584 0.494566820907295 2435 16454030 SGTC_964 1287-0107 19.4 µM -0.0144069630462367 0.475931221574129 no 1585 0.494252652129843 2439 51516812 YPR165W RHO1 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.0145372108807068 0.475984555189851 no 1586 0.494200696202922 2432 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2385 9074692 200 µM -0.0148307750968294 0.476104764838335 no 1587 0.494083593651005 2433 17046906 SGTC_2981 9013952 38.96 µM -0.0149943636908651 0.47617175258249 no 1588 0.494018338500603 2458 2996344 SGTC_1600 coumarin 106 71.1 µM -0.0174397716232667 0.477173199675998 no 1589 0.49304289040314 2542 100336 A hepatotoxic, DNA x-linker. SGTC_3025 9087895 49.47 µM -0.0192991296205557 0.477934743553742 no 1590 0.492301239131177 2443 17173641 SGTC_1133 3473-0247 50 µM -0.0202085499243847 0.478307247582195 no 1591 0.491938503712979 2480 711311 SGTC_1208 2323-2347 50.3 µM -0.0215554590023555 0.478858984368276 no 1592 0.49140128191725 2441 5412760 SGTC_2174 5790901 200 µM -0.0221084519467594 0.479085519653561 no 1593 0.491180722223193 2461 786020 SGTC_517 1365-0151 113 µM -0.02241596208406 0.479211495068714 no 1594 0.491058073824653 2524 768657 SGTC_2488 5268135 45.7 µM -0.0233312516538625 0.479586467252179 no 1595 0.490693021639677 2465 1270356 YLR208W SEC13 SGTC_2800 7887935 81.82 µM -0.0252815834399137 0.480385531253242 no 1596 0.489915181761248 2474 2961002 SGTC_979 1426-2828 121 µM -0.026647114266666 0.48094504548877 no 1597 0.489370597417566 2514 747872 SGTC_1200 1643-0193 18.4 µM -0.0269101416576743 0.481052822992765 no 1598 0.489265702287317 2437 5403974 SGTC_1038 k292-0204 154 µM -0.027686545606936 0.481370968552606 no 1599 0.488956077320751 2449 4454212 SGTC_806 3966-4455 5.86 µM -0.0306742549761606 0.482595345387726 no 1600 0.487764661525498 2473 714982 SGTC_2645 abamectin 100 µM -0.0312886662596298 0.482847154645368 no 1601 0.487519664499346 2464 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3296 9122258 64.045 µM -0.0322455935851195 0.483239353675294 no 1602 0.487138098321926 2490 4730474 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.0326752804343044 0.48341546719163 no 1603 0.486966768359028 2477 6708514 SGTC_1486 3970-0793 4.53 µM -0.0328412554080798 0.483483495359983 no 1604 0.486900589442538 2494 2844330 SGTC_2486 5283202 22.39 µM -0.0331067510542765 0.483592315068725 no 1605 0.486794729569884 2500 1377751 SGTC_787 4152-0075 138 µM -0.0331529102362041 0.483611234632858 no 1606 0.486776324823751 2495 9566539 SGTC_2162 5663267 200 µM -0.0333186959628032 0.48367918661092 no 1607 0.486710222407063 2472 6456493 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0333792824149963 0.483704019803621 no 1608 0.486686065346602 2477 6728940 SGTC_124 0136-0217 7.121 µM -0.0350663318522054 0.484395533160089 no 1609 0.486013424090946 2488 3976905 SGTC_318 1488-0629 67.2 µM -0.0357227130840871 0.484664593431053 no 1610 0.485751729843173 2524 3662576 SGTC_3335 9143315 29.6265 µM -0.0381030141931525 0.48564037135847 no 1611 0.484802774039203 2493 4899691 SGTC_2797 7859098 81.82 µM -0.0381787765556169 0.485671430738058 no 1612 0.484772571206003 2492 972681 SGTC_752 1896-0090 130 µM -0.0383564257799642 0.485744259782896 no 1613 0.484701751293082 2473 772567 SGTC_707 0865-0008 204 µM -0.0384362850752709 0.485776999040653 no 1614 0.484669915519785 2483 723043 SGTC_1392 3455-1037 33.9 µM -0.0399598539205878 0.48640162212254 no 1615 0.484062566320833 2528 981132 SGTC_1359 1582-0056 520 nM -0.0400319232060558 0.486431169469071 no 1616 0.484033837823013 2515 3661189 SGTC_1752 st044819 83.042 µM -0.0405768927060494 0.486654601344574 no 1617 0.48381660296537 2503 441209 YML126C ERG13 SGTC_450 aminopyrene 156 nM -0.0406435184966313 0.486681917520488 no 1618 0.483790045029103 2466 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1729 st035615 45.989 µM -0.0408609057174073 0.486771045415559 no 1619 0.483703392059717 2601 17385451 SGTC_78 0336-0123 156.75 µM -0.0414018565424956 0.486992835958654 no 1620 0.483487766380503 2492 6765896 SGTC_3182 9108849 49.47 µM -0.0432381972621752 0.487745767647326 no 1621 0.482755828267483 2532 17133045 SGTC_3334 9142812 21.919 µM -0.0436767941880937 0.487925606591186 no 1622 0.482581018557822 2567 45283678 SGTC_2857 9024691 58.44 µM -0.0437220438285748 0.487944160549558 no 1623 0.482562983791235 2542 16478292 SGTC_2794 7785382 27.27 µM -0.0452220862359202 0.488559245694779 no 1624 0.481965144993147 2472 2205081 SGTC_1113 artemisinin 1.17947 µM -0.0455788824747069 0.488705552330245 no 1625 0.481822950510219 2486 2240 An anti-malaria and mitochondrial poison. SGTC_2301 7769476 200 µM -0.0458396500351662 0.488812482739428 no 1626 0.481719027926666 2512 977820 SGTC_1891 st059073 26.2 µM -0.0464946720575246 0.489081084758948 no 1627 0.481457990288994 2505 688754 SGTC_2921 7974240 10.71 µM -0.0471406869914731 0.489345998132189 no 1628 0.481200549918351 2515 2979074 YDR527W RBA50 SGTC_595 3909-8003 73.7 µM -0.0508842680454501 0.490881229034436 no 1629 0.479708870775171 2533 699517 SGTC_2030 5175110 200 µM -0.0508920879351289 0.490884436096093 no 1630 0.479705755127314 2555 2831986 SGTC_2339 9000433 200 µM -0.0510754842547978 0.490959650024526 no 1631 0.479632685609665 2543 2988954 SGTC_3089 9117425 49.47 µM -0.0520094482034853 0.491342689345663 no 1632 0.479260582513434 2550 9401657 SGTC_1043 0916-0009 19.3 µM -0.0520732381563283 0.491368851314794 no 1633 0.479235168441979 2490 3101130 SGTC_29 0299-0004 12.984 µM -0.052229609739386 0.491432983648357 no 1634 0.47917286998251 2504 16871 A napthoquinone isolated from Swertia calycina. SGTC_2345 9052315 157.45 µM -0.0524218799433897 0.491511839307788 no 1635 0.479096270205267 2549 6469265 SGTC_2878 9043973 25.97 µM -0.0526389836755624 0.491600880325327 no 1636 0.479009777765423 2641 6465167 SGTC_1702 st027038 51 µM -0.0537532692112743 0.492057890096806 no 1637 0.478565870710554 2540 5521182 SGTC_2334 9017922 200 µM -0.0541733068945718 0.492230165846966 no 1638 0.47839854372914 2572 3163164 SGTC_1330 1469-0054 61.8 µM -0.0546262520329989 0.492415940000982 no 1639 0.478218111941021 2518 7102664 SGTC_1324 1418-0026 34.4 µM -0.0552768894736541 0.492682799956113 no 1640 0.477958936769264 2593 1372513 SGTC_928 2764-0428 58.7 µM -0.0557276398774383 0.492867677860578 no 1641 0.477779390136714 2627 662578 SGTC_4 0960-0234 25.671 µM -0.055760458386902 0.492881138623769 no 1642 0.477766317772023 2515 6821112 SGTC_2600 tangeritin 87.95 µM -0.0558632789463108 0.492923311316683 no 1643 0.47772536214097 2522 68077 A bioactive flavone. SGTC_1662 st014054 52 µM -0.0563766509636482 0.493133876219977 no 1644 0.477520878598983 2495 2838777 SGTC_1502 4534-4282 27.7 µM -0.056386958457546 0.493138103966214 no 1645 0.477516773034656 2525 3278949 SGTC_1044 1222-0021 1.78 µM -0.0576596167353379 0.493660106289094 no 1646 0.477009880663236 2644 4306703 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.0580397391686929 0.493816022081983 no 1647 0.476858487291226 2505 2724 A muscle relaxant with antifungal properties. SGTC_341 1486-1430 230 µM -0.0580535432592057 0.493821684159094 no 1648 0.476852989525804 2509 2054753 YPL210C SRP72 SGTC_1624 st003710 6.25 µM -0.0583000986573434 0.493922814947421 no 1649 0.476754794466633 2512 24207033 SGTC_3138 9097216 49.47 µM -0.0589774389544533 0.494200644796651 no 1650 0.476485038965796 2496 25237486 SGTC_3245 9134821 49.47 µM -0.0591863464942859 0.494286334573639 no 1651 0.476401842248548 2500 17014901 SGTC_1954 st077032 68.9 µM -0.0592769334081114 0.494323491631816 no 1652 0.476365766637727 2587 698907 SGTC_2290 7904846 200 µM -0.0600299548841704 0.494632368836524 no 1653 0.476065888577952 2554 2962154 SGTC_2893 9048488 25.97 µM -0.0605533054626367 0.494847040668041 no 1654 0.47585748104065 2534 6467338 SGTC_1357 1503-1303 39.5 µM -0.061057137572063 0.495053707679327 no 1655 0.475656852344852 2511 292895 SGTC_2722 naftopidil 47.16 µM -0.0619213497665144 0.49540820214302 no 1656 0.475312732732821 2511 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1206 3978-0017 132 µM -0.0628848160149216 0.495803414263845 no 1657 0.474929112988449 2749 3873677 SGTC_2408 sulbentine 18.36 µM -0.0629016302879175 0.495810311486057 no 1658 0.474922418317716 2653 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2809 7964133 12.99 µM -0.0629637120955442 0.495835777481809 no 1659 0.474897700256513 2545 1253665 SGTC_1803 st050068 52.4 µM -0.0630214588317647 0.495859465243833 no 1660 0.474874708303955 2501 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2229 7354935 190 µM -0.0630600852610604 0.495875309847282 no 1661 0.474859329177943 2513 318112 SGTC_1715 st032160 10.2275 µM -0.063618703233438 0.496104456264107 no 1662 0.474636919441281 2548 5289825 SGTC_1492 4158-0558 28.5 µM -0.0639387155221868 0.496235726647643 no 1663 0.47450951240161 2607 3967268 SGTC_3213 9129884 49.47 µM -0.064132177696293 0.496315085841774 no 1664 0.474432490238985 2565 17190742 SGTC_1555 citronellol 128 µM -0.0674915592426949 0.497693142215303 no 1665 0.473095190726892 2528 8842 A terpine precursor. SGTC_248 streptozotocin 5.23457 mM -0.0677104134850632 0.497782919838073 no 1666 0.473008079787965 2616 5300 DNA alkylating agent. SGTC_2063 5246145 200 µM -0.0683724311849573 0.498054491091098 no 1667 0.472744583594027 2587 711240 SGTC_2684 capsaicin 100 µM -0.0687300551312128 0.498201195079248 no 1668 0.472602247114335 2594 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_622 1348-1566 26.3 µM -0.0703227002144789 0.498854530363577 no 1669 0.471968407536628 2596 7340407 SGTC_962 1254-0300 21.5 µM -0.0706307560051422 0.498980901499881 no 1670 0.471845815890327 2517 7340576 SGTC_1844 rapamycin 4 nM -0.0706832172556192 0.499002422248013 no 1671 0.47182493905738 2520 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2478 5763493 32.33 µM -0.0710966694143784 0.499172029429663 no 1672 0.47166040944357 2547 1365576 YLR208W SEC13 SGTC_2988 9073640 71.4286 µM -0.0712859739749027 0.499249686381547 no 1673 0.471585078987764 2618 9102229 SGTC_2949 9072542 2.23 µM -0.0717331701750641 0.499433136342141 no 1674 0.471407129083511 2590 16457352 SGTC_3174 9107204 49.47 µM -0.0719924977189507 0.499539518402984 no 1675 0.471303939156533 2592 3938802 SGTC_435 c-PAF 6.7 µM -0.0725020073426506 0.499748530935437 no 1676 0.471101204023384 2534 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2836 9010338 19.48 µM -0.0728704628557977 0.499899679883189 no 1677 0.470954599331007 2553 2994051 SGTC_2266 7929956 200 µM -0.0729976516906658 0.499951855680558 no 1678 0.470903993103164 2526 2967153 SGTC_1484 3473-2379 286 µM -0.0732323743057 0.499951855680558 no 1679 0.470810602286536 2525 671917 SGTC_226 1,3-diallylurea 8.28947 mM -0.0735649136393913 0.499815440370205 no 1680 0.470678295160595 2631 74537 YKL182W FAS1 SGTC_700 3453-2283 142 µM -0.0742438111282129 0.499536941034171 no 1681 0.470408192891228 2614 565664 SGTC_3068 9116768 49.47 µM -0.0745119839956869 0.499426930421859 no 1682 0.470301502913073 2604 41904888 SGTC_3044 9093193 49.47 µM -0.0746137757598372 0.499385173134965 no 1683 0.470261006603293 2613 25236277 SGTC_1572 epiandrosterone 68.9 µM -0.0748747290254233 0.49927812422757 no 1684 0.470157191709639 2560 441302 A steroid. SGTC_925 2064-1272 59.6 µM -0.0749389999270848 0.499251758863717 no 1685 0.470131623163337 2577 6815817 SGTC_1922 5578187 25 µM -0.0764190124217858 0.498644625716679 no 1686 0.469542872054237 2615 1350412 SGTC_866 0495-0101 262 µM -0.0764236659835006 0.498642716729193 no 1687 0.469541020965 2572 635694 SGTC_710 3448-4187 58 µM -0.0787790899187345 0.497676477935161 no 1688 0.468604168087689 2565 3946412 SGTC_546 peri-Naphthalide 147 µM -0.0798617163339777 0.497232368633453 no 1689 0.468173619238189 2623 223824 A penicillin ester. SGTC_251 melphalan 456.522 µM -0.0808111371895663 0.496842905018568 no 1690 0.467796075421842 2591 460612 A DNA alkylator. SGTC_1010 4112-3296 15.2 µM -0.0814431730069047 0.49658363812909 no 1691 0.467544758015294 2553 704384 SGTC_1489 4065-0444 182 µM -0.0822037358458311 0.496271650199265 no 1692 0.467242351363502 2554 2877968 SGTC_2640 pentamidine 10.38 µM -0.0842642960591772 0.495426406713101 no 1693 0.4664231495128 2596 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1181 1222-0449 220 µM -0.0845674348323262 0.495302060581664 no 1694 0.466302644766362 2652 658318 SGTC_2835 9006588 71.43 µM -0.0856700083591271 0.49484979392755 no 1695 0.465864372156287 2768 2345538 SGTC_3289 9119912 71.43 µM -0.0865428940235309 0.494491748024505 no 1696 0.465517429727999 2624 17014829 SGTC_564 3555-0129 330 µM -0.0869926902557047 0.494307249402982 no 1697 0.465338661205894 2559 563260 SGTC_2976 9009005 19.48 µM -0.0881011537095092 0.493852582179154 no 1698 0.464898139709718 2580 2993148 SGTC_2051 5263410 176 µM -0.0882550717300843 0.493789449025051 no 1699 0.4648369735615 2547 227584 SGTC_774 k060-0086 136 µM -0.0884631165895644 0.493704114702105 no 1700 0.464754299035359 2557 5911235 SGTC_1903 st060211 78.3 µM -0.0891195894348442 0.493434849366113 no 1701 0.464493434610646 2573 688960 SGTC_514 4466-0038 2.65 nM -0.0916616377899092 0.492392207225406 no 1702 0.463483438819901 2643 5722064 SGTC_1260 0700-1617 7.75 µM -0.0929000774273981 0.491884269361063 no 1703 0.462991472118347 2628 2853078 SGTC_2837 9008476 45.46 µM -0.0933190261051372 0.491712443256637 no 1704 0.462825058695688 2722 2992805 SGTC_2977 9011197 71.43 µM -0.0935569508776757 0.491614862328464 no 1705 0.462730553890898 2786 2704722 SGTC_1464 k208-0027 110 µM -0.0936824210854822 0.491563402990247 no 1706 0.462680717398949 2589 X1464 SGTC_2678 equilin 100 µM -0.0945063375956318 0.491225492051347 no 1707 0.462353474153319 2593 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1366 1683-0113 21.9 µM -0.0952132835589447 0.490935558977896 no 1708 0.462072709584058 2573 708623 SGTC_2844 9010103 25.97 µM -0.0957438935381352 0.490717948054683 no 1709 0.461861989502797 2734 2480525 SGTC_2242 6630449 61.2675 µM -0.0962474484123641 0.490511435380226 no 1710 0.461662023660452 2753 691249 YDR170C SEC7 SGTC_1048 3161-0300 24.5 µM -0.0963045242196744 0.490488028204715 no 1711 0.461639358991664 2568 2165101 SGTC_1085 doxorubicin 7.67 µM -0.0971959047976067 0.490122471288415 no 1712 0.461285410073413 2588 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1838 st055369 84.5 µM -0.0974227159510456 0.490029456903275 no 1713 0.461195352906033 2561 676036 SGTC_200 k038-0079 37.545 µM -0.0978919452585941 0.489837029488754 no 1714 0.461009048009888 2616 3436683 SGTC_2910 7948405 25.97 µM -0.0981412038982964 0.489734811352039 no 1715 0.46091008472607 2625 2971328 SGTC_2957 9076800 11.52 µM -0.098450558847187 0.48960794933996 no 1716 0.460787264741624 2630 16459615 SGTC_1040 k898-0338 155 µM -0.0985224112006211 0.489578483873949 no 1717 0.460758738482395 2577 20969351 SGTC_2388 9080168 200 µM -0.100546970589078 0.488748269411332 no 1718 0.459955047302909 2580 15943073 SGTC_2556 citropten 84.59 µM -0.10104566659735 0.488543775647776 no 1719 0.459757104479987 2579 2775 A potential DNA crosslinker. SGTC_1611 st001856 99.4 µM -0.10158024623811 0.488324570897372 no 1720 0.459544929774605 2592 647478 SGTC_1768 st044301 37.178 µM -0.1017525772719 0.488253907186659 no 1721 0.459476534025295 2620 3931349 SGTC_2492 derrusnin 100 µM -0.102188651440765 0.488075098219237 no 1722 0.459303467718591 2566 1715307 Part of coumarin class of compounds. SGTC_1125 tnp00248 1.32998 µM -0.102517896058697 0.487940095500239 no 1723 0.459172804343517 2713 24207736 SGTC_2982 9019404 25.97 µM -0.102911505979142 0.487778702392899 no 1724 0.459016602869397 2615 22333232 SGTC_2050 5263056 171 µM -0.103006348887076 0.487739813956809 no 1725 0.458978966038418 2630 763468 YGL055W OLE1 SGTC_1111 tnp00062 510.699 nM -0.103090069580183 0.487705486059149 no 1726 0.458945743178983 2711 676306 SGTC_898 1000-0849 28.3 µM -0.103386280655207 0.487584031712252 no 1727 0.458828200123716 2559 6751807 SGTC_2793 7325131 81.82 µM -0.103833610888734 0.487400616714057 no 1728 0.458650696495842 2662 4176441 SGTC_558 k064-0027 21.3 µM -0.105155665427652 0.486858561697784 no 1729 0.45812614473739 2676 5088526 SGTC_1344 1488-0097 29.1 µM -0.106413019208948 0.486343057120737 no 1730 0.457627331946882 2683 747966 SGTC_2482 5981709 142.65 µM -0.106439143554123 0.486332346595838 no 1731 0.457616968697276 2667 877755 SGTC_2902 5787006 60.46 µM -0.106957930030333 0.486119655260282 no 1732 0.457411177602442 2611 591003 SGTC_771 0250-0039 27.3 µM -0.109193005556673 0.485203368112564 no 1733 0.456524703947752 2584 3005115 SGTC_904 1141-0088 396 µM -0.109235316387226 0.485186023186233 no 1734 0.456507924736495 2633 1378119 SGTC_1630 st005209 31.3 µM -0.110217557286288 0.484783370730588 no 1735 0.456118419201935 2579 3367314 SGTC_173 1273-0061 2.693 µM -0.11029814814992 0.484750334600501 no 1736 0.456086462933455 2697 2847414 YPL266W DIM1 SGTC_3252 9135871 49.47 µM -0.110371720581684 0.484720175585549 no 1737 0.45605728989463 2727 17682838 SGTC_1754 st042065 16.137 µM -0.111432121171419 0.484285503034002 no 1738 0.455636844827837 2654 1126236 YIL048W NEO1 SGTC_2940 9060638 45.86 µM -0.111835224219893 0.484120270510136 no 1739 0.455477028907607 2684 4027022 SGTC_1840 st055363 71 µM -0.112632738137178 0.483793376460953 no 1740 0.455160864456533 2658 676033 SGTC_957 1187-1561 14.1 µM -0.113262017488285 0.483535447981458 no 1741 0.454911414536697 2589 1538454 SGTC_2592 piperlongumine 83.33 µM -0.113403740235572 0.483477359730365 no 1742 0.454855237281657 2678 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_975 1335-0046 28.5 µM -0.113772835397768 0.483326079437272 no 1743 0.45470893647605 2647 16486740 SGTC_3123 9126162 49.47 µM -0.11477926861347 0.482913586935727 no 1744 0.454310040844749 2622 25239884 SGTC_1994 st072947 40.9 µM -0.116392653136788 0.482252370256749 no 1745 0.453670678884176 2737 5286565 YDL195W SEC31 SGTC_229 benomyl 22.8748 µM -0.118543879241216 0.481370805112809 no 1746 0.452818364785291 2681 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_505 gw-5074 63.9 µM -0.11858158866145 0.481355352720394 no 1747 0.452803426269313 2732 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2827 7993847 71.43 µM -0.118946020677393 0.481206018895589 no 1748 0.45265906065623 2694 2985692 SGTC_2314 7727897 200 µM -0.119395218048748 0.481021954281631 no 1749 0.452481124820611 2641 900724 SGTC_2288 7946289 167.31 µM -0.120219521095829 0.480684195667002 no 1750 0.45215462716319 2711 1246052 SGTC_1470 k295-0292 231 µM -0.120349646015721 0.480630878172499 no 1751 0.452103089019542 2719 5045612 SGTC_2413 inermin 26.06 µM -0.120516069239452 0.480562688285445 no 1752 0.452037175503918 2887 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_174 3553-0389 74.3 µM -0.12059929777378 0.48052858662137 no 1753 0.452004212539572 2741 738071 SGTC_2369 9071472 200 µM -0.120634885158674 0.480514005258906 no 1754 0.451990118127054 2751 17296037 SGTC_2790 5423970 71.43 µM -0.121079407195085 0.480331871658712 no 1755 0.451814069919649 2735 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_649 1123-0311 367 µM -0.121931502215474 0.479982755070527 no 1756 0.451476633300988 2696 693629 YIL048W NEO1 SGTC_3343 9148379 18.9835 µM -0.123000847554723 0.479544649404236 no 1757 0.451053213406267 2721 1955036 SGTC_932 2857-0803 154 µM -0.123246990710824 0.479443809210903 no 1758 0.450955757988806 2855 674898 SGTC_382 3229-0966 23.2 µM -0.123582027620327 0.479306553044393 no 1759 0.450823111634714 2752 5722370 SGTC_2406 ethylparaben 405.7 µM -0.123605885926362 0.479296778991922 no 1760 0.450813665967393 2628 8434 A possible steroid mimic. SGTC_265 mycophenolic acid 32.932 µM -0.123942649013675 0.479158818303072 no 1761 0.450680342120765 2861 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2442 5158906 48.48 µM -0.124306298893648 0.479009845789655 no 1762 0.450536380094919 2745 1893835 SGTC_489 paxilline 115 µM -0.124823859446622 0.47879782741689 no 1763 0.450331499006325 2682 105008 A toxic potassium channel blocker. SGTC_2453 5731132 22.18 µM -0.12511459481347 0.478678730474563 no 1764 0.450216414548968 2731 1362040 SGTC_1652 st011932 78 µM -0.126447970995174 0.47813255031585 no 1765 0.449688665747597 2642 1551076 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.127536922416586 0.477686522323471 no 1766 0.449257725953738 2739 521171 SGTC_1372 2752-0194 270 µM -0.12978396523847 0.476766235977745 no 1767 0.448368674746895 2628 823334 SGTC_2323 6148992 148.28 µM -0.130337040762134 0.476539740258412 no 1768 0.448149887857104 2696 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_908 3448-7491 47.7 µM -0.132880397169654 0.475498282571955 no 1769 0.447143985100602 2657 1203031 SGTC_1428 4049-0204 61.7 µM -0.132941361580769 0.475473320792215 no 1770 0.447119877694865 2744 X1428 SGTC_2140 5586273 200 µM -0.133907792121444 0.475077630290155 no 1771 0.446737744280873 2630 854421 SGTC_3112 9123419 49.47 µM -0.134468715172724 0.474847980001211 no 1772 0.446515974029374 2633 17015854 SGTC_1248 0469-0687 58.6 µM -0.134857510779997 0.47468880616187 no 1773 0.446362267034724 2734 4017482 SGTC_2711 st079103 59.1 µM -0.135758620274332 0.474319905383644 no 1774 0.446006052180163 2740 54693780 SGTC_639 0833-0042 114 µM -0.135826667891911 0.474292048594762 no 1775 0.445979154249298 2673 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_760 0568-0725 82.9 µM -0.135857526333113 0.474279416054577 no 1776 0.445966956575481 2804 3916171 SGTC_2693 st077581 40.7 µM -0.137423698446088 0.473638305396075 no 1777 0.445347950049971 2658 25238761 SGTC_1311 1190-0148 100 µM -0.138499131335945 0.473198117679321 no 1778 0.444922978047053 2764 1961333 SGTC_1736 st036774 51 µM -0.139134487181181 0.472938074175108 no 1779 0.444671938213698 2926 1272247 SGTC_2686 alizarin 95.37 µM -0.139324098422227 0.472860470804649 no 1780 0.444597023902454 2704 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2021 4019055 173 µM -0.139640661377327 0.472730911414555 no 1781 0.444471956110288 2755 44827708 YER133W GLC7 SGTC_2163 5671233 125 µM -0.141108060083718 0.472130388574942 no 1782 0.44389228816992 2718 701023 SGTC_2996 9066192 71.4286 µM -0.142349255447334 0.471622487298286 no 1783 0.443402071197065 2699 6472854 SGTC_2506 ethyl hematommate 54.16 µM -0.142758382581782 0.471455081184423 no 1784 0.443240503115062 2724 3940691 An allergen. SGTC_97 0535-0701 19.132 µM -0.143670882415213 0.471081723890004 no 1785 0.442880182540447 2691 2832013 YGL099W LSG1 SGTC_1804 st050076 49.1 µM -0.144020519291986 0.470938673618298 no 1786 0.442742133251184 2754 3895976 SGTC_395 anisomycin 6.25 µM -0.144253412150235 0.470843390020454 no 1787 0.442650182580585 2711 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1619 st003326 88.7 µM -0.144655075571855 0.470679061143453 no 1788 0.442491605240527 2831 2849032 SGTC_1261 0712-0010 12.7 µM -0.145023185210466 0.470528464202249 no 1789 0.442346283076425 2756 2840123 SGTC_2666 tannic acid 100 µM -0.145270505884575 0.470427285471252 no 1790 0.442248650283384 2714 16134267 A thiamine antagonist. SGTC_1112 tnp00069 1.16933 µM -0.146026195840007 0.470118145045757 no 1791 0.441950354396576 2782 145826 SGTC_2764 methyldopa 94.69 µM -0.147257759905358 0.469614370964878 no 1792 0.441464285824606 2775 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2236 dapsone 200 µM -0.148218624373258 0.469221360904588 no 1793 0.441085117016793 2681 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_812 4251-0442 148 µM -0.149145031164804 0.468842473014106 no 1794 0.440719596750137 2655 5723007 SGTC_160 3453-0671 289.699 µM -0.149342144880101 0.468761859790464 no 1795 0.440641830663002 2693 5322268 SGTC_1856 st057054 55.7 µM -0.149368582352624 0.468751047804621 no 1796 0.440631400620209 2912 1266018 SGTC_3344 9148862 3.898 µM -0.149837915887676 0.468559110927198 no 1797 0.440446247238924 2802 4905352 SGTC_2436 5633522 8.09 µM -0.150977959027685 0.468092913694522 no 1798 0.439996551363081 2733 5724242 SGTC_2456 5770359 74.46 µM -0.151990329161526 0.467678962374884 no 1799 0.439597281622515 2837 3118787 SGTC_2347 9049783 174.81 µM -0.153311748772013 0.46713869545746 no 1800 0.439076218012708 2803 6467988 YPL169C MEX67 SGTC_1007 4101-0031 70 µM -0.153595846548517 0.467022548984418 no 1801 0.438964206025761 2822 1146276 SGTC_113 0099-0221 2.5 µM -0.154925449002631 0.466479010809226 no 1802 0.438440045234389 2690 89219 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.154942884705185 0.46647188355044 no 1803 0.43843317238249 2810 5282362 SGTC_538 2922-0838 53.3 µM -0.155270694907092 0.466337885324924 no 1804 0.438303958738104 2679 777039 SGTC_8 0354-0001 70 µM -0.156393403798069 0.465878987187952 no 1805 0.437861468103953 2695 4993152 SGTC_3320 9137005 35.139 µM -0.156426462423798 0.465865475427867 no 1806 0.437848439959754 2747 4908713 SGTC_2729 fluphenazine 10.66 µM -0.156803345591335 0.465711438084956 no 1807 0.437699918035425 2705 3372 An atypical antipsychotic. SGTC_1681 tripelennamine 100 µM -0.156932142884223 0.465658798033491 no 1808 0.437649163675858 2660 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2251 lansoprazole 556 µM -0.157362414638753 0.465482948331837 no 1809 0.437479616566078 2694 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1139 k015-0024 46.9 µM -0.157393338758283 0.465470310073321 no 1810 0.437467431464596 2667 2766652 SGTC_2980 9014342 25.29 µM -0.157488148489498 0.465431562868978 no 1811 0.43743007373926 2860 2996599 SGTC_424 splitomicin 100 mM -0.157644609134735 0.465367620649649 no 1812 0.437368425023753 2781 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3134 9127454 49.47 µM -0.160421944415857 0.464232731684427 no 1813 0.43627435216748 2679 24262820 SGTC_1714 st033236 13.627 µM -0.161226229687897 0.463904134436672 no 1814 0.435957611527282 2826 2916566 SGTC_1989 st071868 50.2 µM -0.163828425838172 0.462841156003543 no 1815 0.434933106713199 2828 16414057 SGTC_2299 7976368 114.88 µM -0.164634251589651 0.462512035415317 no 1816 0.434615935096792 2819 2979718 SGTC_1 0258-0098 57.368 µM -0.164656591688901 0.462502911491418 no 1817 0.434607142670998 2765 6790032 YDR047W HEM12 SGTC_2726 cimetidine 79.27 µM -0.166709053906055 0.461664749819522 no 1818 0.433799490624577 2693 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_462 ag-879 158 µM -0.167485053272823 0.461347899983343 no 1819 0.43349420358912 2814 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_83 0170-0301 39.027 µM -0.167801838537912 0.461218559805687 no 1820 0.433369588032955 2693 3089716 SGTC_3101 9120531 49.47 µM -0.168210243614077 0.461051818253117 no 1821 0.433208941265977 2919 24824904 SGTC_807 1315-0151 48 µM -0.168969470074015 0.460741863343674 no 1822 0.432910327712955 2809 4011080 SGTC_2239 6685329 187.64 µM -0.169373189053822 0.460577054395191 no 1823 0.432751555423773 2845 805680 SGTC_2752 diclazuril 33.15 µM -0.170060564656733 0.460296464777668 no 1824 0.432481253272934 2847 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2669 eugenol 100 µM -0.170651544198361 0.46005524023871 no 1825 0.432248882963549 2711 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1820 st053765 18.6 µM -0.171106656166268 0.459869483799065 no 1826 0.432069951097467 2780 3690829 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.17136666898175 0.459763362074913 no 1827 0.431967730685159 2678 2333 A French combination drug. SGTC_182 3448-4371 550.524 µM -0.17192016877813 0.459537466023958 no 1828 0.431750145135044 2684 3491403 SGTC_2723 salbutamol 83.58 µM -0.171920297649228 0.459537413430204 no 1829 0.43175009447711 2811 9884233 β2-adrenoceptor agonist SGTC_765 1319-0117 244 µM -0.173764056321301 0.458785027572598 no 1830 0.431025446749452 2719 3487746 YGL099W LSG1 SGTC_2917 7979103 53.79 µM -0.175050787806888 0.458260036080012 no 1831 0.430519863366957 2871 2980565 SGTC_1218 1348-1416 30.7 µM -0.175141890752834 0.458222868469913 no 1832 0.430484071444306 2705 6787668 SGTC_2539 epi(13)torulosol 80 µM -0.175286407540029 0.458163910164373 no 1833 0.430427295816706 2805 6708597 SGTC_3205 9113483 49.47 µM -0.17574580846488 0.457976495150716 no 1834 0.430246822703456 2896 17018033 SGTC_117 lucigenin 22.078 µM -0.176047134885463 0.457853572530329 no 1835 0.430128456195591 2756 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1386 3228-0095 33.8 µM -0.176540706224712 0.457652234538611 no 1836 0.429934585951591 2849 870181 SGTC_1251 0490-5699 265 µM -0.177079791939402 0.457432342706876 no 1837 0.429722857385301 2808 3883818 SGTC_3091 9116372 49.47 µM -0.177341461674603 0.457325612912932 no 1838 0.429620092591991 2877 17169793 SGTC_744 1594-0068 283 µM -0.177542404037576 0.457243654675004 no 1839 0.429541180319474 2763 668392 SGTC_1689 st020265 53.493 µM -0.178323450703891 0.456925106953953 no 1840 0.429234481482541 2839 5758320 YPR016C TIF6 SGTC_204 PMA1.184 62.41 µM -0.179507078754066 0.456442420346593 no 1841 0.428769779782897 2688 2252213 YGL008C PMA1 SGTC_210 3551-0445 56.827 µM -0.179774105928122 0.456333534827682 no 1842 0.428664956436145 2864 2865180 YOR207C RET1 SGTC_2584 androsterone 48.74 µM -0.180982803900551 0.455840705874858 no 1843 0.428190536809762 2819 2754130 A steroid. SGTC_1296 1068-0102 11.9 µM -0.181394733118593 0.455672763233676 no 1844 0.428028876333761 2843 767053 SGTC_1479 0549-0158 134 µM -0.1814412665797 0.455653792140704 no 1845 0.428010615165198 2769 5440202 SGTC_2472 5377652 49.4 µM -0.181870656451246 0.455478740195365 no 1846 0.427842116586808 2770 1610903 SGTC_306 1672-3436 11.6 µM -0.181942516761518 0.455449445314877 no 1847 0.42781391888262 2828 6797378 SGTC_2906 7926292 26.41 µM -0.182005682875666 0.455423694947493 no 1848 0.42778913305138 2868 2966319 SGTC_1711 st032263 62.8 µM -0.182170650299674 0.455356445029947 no 1849 0.427724402619818 2773 3958979 SGTC_2586 curcumin 80 µM -0.182213342780169 0.455339041403448 no 1850 0.427707651128154 2852 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.182990356444758 0.455022306121569 no 1851 0.427402792650481 2863 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2179 6298986 200 µM -0.183052721253204 0.454996885495061 no 1852 0.427378325921989 2845 738374 SGTC_1066 ketoconazole 628 nM -0.183096283983014 0.454979128925382 no 1853 0.427361235720381 2881 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1774 st048371 48.465 µM -0.183731008277028 0.454720419681874 no 1854 0.427112240951003 2734 4242727 SGTC_1562 morin hydrate 59.1 µM -0.184511558001795 0.454402299340753 no 1855 0.426806080423033 2910 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_686 1319-0111 510 µM -0.18603873141012 0.453779970307622 no 1856 0.426207194105181 2885 4562600 SGTC_3229 9132204 49.47 µM -0.186835621597296 0.453455279449905 no 1857 0.425894758333495 2719 17682924 SGTC_1706 st031321 9.9705 µM -0.186984102487421 0.453394784724941 no 1858 0.425836548745604 2839 6103185 SGTC_567 1080-0542 68.4 µM -0.187164387946106 0.453321333499287 no 1859 0.425765872851447 2733 5950415 SGTC_467 ro 31-8220 72.8 µM -0.18868473530746 0.452701983036781 no 1860 0.425169958072562 2818 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1456 k015-0012 13 µM -0.189304733037171 0.452449444829167 no 1861 0.424926992984412 2737 2989616 SGTC_969 1313-0238 134 µM -0.189560311909473 0.452345347734069 no 1862 0.424826844875062 2748 5212874 SGTC_735 3076-0345 636 µM -0.190557458956144 0.451939241829061 no 1863 0.424436161095394 2881 2888990 SGTC_776 4476-4378 112 µM -0.190823357790051 0.451830958264859 no 1864 0.424331994034944 2840 2892008 SGTC_376 3970-0862 59.1 µM -0.191158615994819 0.451694434179812 no 1865 0.424200662663906 2857 3135186 SGTC_2543 pimpinellin 60.67 µM -0.191558910955257 0.451531433264645 no 1866 0.424043865338778 2755 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.191906264578671 0.451389996789434 no 1867 0.423907815113914 2744 688664 SGTC_2131 toluylene red 5.2905 µM -0.193117821820406 0.45089671974253 no 1868 0.423433347789588 2788 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2780 5215298 71.43 µM -0.193990388107004 0.450541507415244 no 1869 0.423091704060985 2867 2834131 SGTC_3260 9137109 49.47 µM -0.19410521628758 0.45049476504433 no 1870 0.423046748650489 2858 17478346 SGTC_901 1112-0062 60.1 µM -0.19481227129245 0.450206963853958 no 1871 0.422769957622886 2750 1908457 SGTC_1412 3909-8563 178 µM -0.195393395741941 0.449970441304733 no 1872 0.422542493203438 2841 23767530 SGTC_986 1493-0483 84 µM -0.195454040121847 0.449945759553503 no 1873 0.422518757195472 2771 40079 SGTC_54 0159-0055 9 µM -0.197369101711292 0.449166445727214 no 1874 0.4217693536406 2981 3319099 SGTC_2378 9074213 121.43 µM -0.197943328656548 0.44893280828606 no 1875 0.421544701726222 2758 657714 SGTC_1118 chelidonine 707.474 nM -0.199083966317848 0.448468766214328 no 1876 0.421098531604723 2806 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2102 5377816 72.7585 µM -0.20038062585285 0.447941335901704 no 1877 0.420591455270724 2940 1379702 SGTC_1772 st048439 82.2 µM -0.203335574133377 0.446739723944417 no 1878 0.419436376062839 2839 2927068 YDL195W SEC31 SGTC_1404 3909-7820 48.3 µM -0.204458095798607 0.446283384775562 no 1879 0.418997767492012 2843 23741373 SGTC_1019 4262-0212 3.4 µM -0.204951426940582 0.446082853140137 no 1880 0.418805037525191 2844 4677213 SGTC_2003 4023581 200 µM -0.206627311289349 0.445401734835194 no 1881 0.418150464602301 2897 16641307 SGTC_311 1315-0136 58 µM -0.206645015901883 0.445394540126223 no 1882 0.418143550677843 2924 6759207 SGTC_1457 k015-0032 57.3 µM -0.207937989932877 0.444869156787674 no 1883 0.417638692875147 2755 4302660 SGTC_537 1334-0398 209 µM -0.208082972321631 0.444810251082739 no 1884 0.417582091144361 2921 5846986 SGTC_3288 9119690 36.221 µM -0.209175502796047 0.444366400056823 no 1885 0.417155617674524 2828 17595618 YKL019W RAM2 SGTC_3275 9138069 49.47 µM -0.209797043891162 0.444113924097304 no 1886 0.41691304017784 2850 17617007 SGTC_363 0455-0021 3.06 µM -0.210176638380094 0.443959740319779 no 1887 0.41676490610328 2766 4597466 SGTC_3013 9080133 71.4286 µM -0.210916293246767 0.443659331520582 no 1888 0.416476294971027 2978 17050193 SGTC_2564 betulinic acid 100 µM -0.211233308530871 0.443530586532014 no 1889 0.416352610323079 3055 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_953 1188-0045 9.7 µM -0.214889475633664 0.442046192634423 no 1890 0.414926745225269 2910 6144426 SGTC_2353 9059630 146.67 µM -0.215375260744577 0.441849025966973 no 1891 0.41473737823931 2902 4779114 SGTC_2235 salicylic acid 500 µM -0.215534136259932 0.441784545937406 no 1892 0.414675450260637 2787 338 A COX inhibitor and kinase inhibitor. SGTC_308 4092-1169 104 µM -0.216594170187474 0.441354368052712 no 1893 0.414262314706765 2808 2268590 YDL196W YDL196W SGTC_2730 imipramine 71.33 µM -0.217901716709607 0.440823841134621 no 1894 0.413752844772452 2799 3696 A tricyclic antidepressant. SGTC_381 3461-2219 42.7 µM -0.220385700249145 0.439816277218281 no 1895 0.412785390600777 2922 2883159 SGTC_1177 0983-0204 23.6 µM -0.221728366933111 0.439271820896623 no 1896 0.41226267304736 2928 766818 SGTC_3169 9102970 49.47 µM -0.2224177277183 0.4389923271013 no 1897 0.411994356347498 2793 17027839 SGTC_2390 9097792 176.6 µM -0.223770703423273 0.438443866443674 no 1898 0.411467863602707 2803 4497149 SGTC_61 0978-8327 98.565 µM -0.223880031358679 0.438399552930232 no 1899 0.411425327018267 2781 6150059 YHR072W ERG7 SGTC_2595 hexamethylquercetagetin 100 µM -0.224965940676785 0.437959447086742 no 1900 0.411002885263821 2903 386331 SGTC_1402 3909-7673 35.9 µM -0.225775824147085 0.437631261085033 no 1901 0.410687890568944 2773 5328014 SGTC_3085 9117376 49.47 µM -0.226326113391954 0.437408293929268 no 1902 0.410473894857608 2880 16480349 SGTC_808 0711-0032 135 µM -0.226508901261027 0.437334236015844 no 1903 0.410402818460317 2774 4252555 SGTC_354 2783-3500 4.88 µM -0.226601411932826 0.437296755441048 no 1904 0.410366847143866 2828 6740761 SGTC_249 wiskostatin 11.211 µM -0.226940728785371 0.437159286492255 no 1905 0.410234915591925 2814 2775510 A n-wasp and actin depolymerizer. SGTC_631 k072-0230 41.5 µM -0.22728253626251 0.437020816175993 no 1906 0.410102025918404 2913 5773147 SGTC_1813 st051246 8.6015 µM -0.227361059270054 0.436989006651241 no 1907 0.410071498796285 2880 5291959 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.228738164220099 0.436431210389098 no 1908 0.409536215147283 2975 23847180 SGTC_1563 conessine 56.1 µM -0.22909900302751 0.436285073507933 no 1909 0.409395984163889 2933 441082 An anti-amoebic, histamine inhibitor. SGTC_2964 9083345 53.42 µM -0.229608300017592 0.436078827034103 no 1910 0.409198078349664 2859 17741579 SGTC_1385 3091-4834 14.1 µM -0.230020433089361 0.43591194107939 no 1911 0.409037946037346 2924 4072814 SGTC_1997 st073024 93.8 µM -0.231538427226723 0.435297354999649 no 1912 0.408448267875853 2929 686268 SGTC_1145 3546-0597 10.2 µM -0.231881804518964 0.435158354405393 no 1913 0.408314908642029 2859 875334 SGTC_1569 carminic acid 40.6 µM -0.232950009815574 0.434725991647781 no 1914 0.40790011212847 2947 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_768 0384-0033 77.3 µM -0.235890250525412 0.433536315473935 no 1915 0.406758916876534 2836 3965305 YMR134W ERG29 SGTC_2389 9091542 195.52 µM -0.236305136899578 0.433368492929738 no 1916 0.406597950567072 2887 3626624 YOL127W RPL25 SGTC_1713 st033146 12.748 µM -0.236574768759998 0.433259432627538 no 1917 0.406493348105246 2947 674619 SGTC_316 k060-0003 58.6 µM -0.237896508931623 0.432724890760969 no 1918 0.4059806816325 2968 6152314 SGTC_3242 9133940 49.47 µM -0.237903289689304 0.432722148784458 no 1919 0.405978051978881 2973 17248444 SGTC_1137 ixabepilone 100 µM -0.23866516239104 0.432414086315418 no 1920 0.40568261627133 2809 154225 A novel microtubule stabilizer. SGTC_1022 4477-0945 21.3 µM -0.239595467085674 0.432037974264027 no 1921 0.405321939589001 2844 4648966 SGTC_2854 9024559 71.43 µM -0.240299734108896 0.431753287721445 no 1922 0.405048950561958 2920 3163529 SGTC_1242 0402-0103 60.1 µM -0.240828822592572 0.431539437075495 no 1923 0.404843894881634 2806 432868 SGTC_1053 3366-3204 134 µM -0.240912233131967 0.431505725455526 no 1924 0.404811570337113 2883 3632071 YPR165W RHO1 SGTC_689 0833-0039 98 µM -0.241341762510508 0.431332132622364 no 1925 0.404645122746991 2870 5374726 SGTC_1515 3460-0031 42.1 µM -0.24144010451327 0.431292389902058 no 1926 0.404607016512545 2854 2876596 SGTC_1921 5740136 50 µM -0.242480031796187 0.430872169202739 no 1927 0.404204113787198 3028 1774243 SGTC_2624 nerol 100 µM -0.242490000743239 0.430868141262545 no 1928 0.404200251973504 2805 637566 A natural product oil. SGTC_691 1548-0686 185 µM -0.242519946734006 0.430856041666859 no 1929 0.40418865142262 2857 46495133 SGTC_2069 5228469 200 µM -0.242804728898294 0.430740979457022 no 1930 0.404078336025381 2961 2835210 SGTC_581 0958-0271 211 µM -0.242982944118149 0.430668977105543 no 1931 0.404009305094495 2831 4591145 SGTC_2487 5918373 44.05 µM -0.243199073965482 0.430581659613224 no 1932 0.403925592099876 2851 2876279 SGTC_1845 st056753 3.01 µM -0.243473024566007 0.430470987137739 no 1933 0.403819489871554 2780 5375839 SGTC_1453 4237-0541 195 µM -0.247645399194106 0.428786082089112 no 1934 0.402204390555465 2974 739892 SGTC_773 4358-1457 44.6 µM -0.247791987461225 0.428726909633074 no 1935 0.402147677357987 3024 1186886 SGTC_3038 9091290 49.47 µM -0.247858546041176 0.428700042836614 no 1936 0.402121927342035 2987 25236843 SGTC_3340 9146634 11.102 µM -0.251625598595539 0.427179990188592 no 1937 0.40066523515365 2926 4907387 SGTC_1234 0326-0494 15.5 µM -0.251645865150388 0.427171815283326 no 1938 0.400657401937451 2999 1547813 SGTC_1338 1486-1223 76 µM -0.252220238107998 0.426940143903785 no 1939 0.400435417947946 2917 3444526 SGTC_3188 9110789 49.47 µM -0.253267652118674 0.426517737952229 no 1940 0.400030695616143 3010 849217 SGTC_277 nystatin 15.5 µM -0.253454384256518 0.426442440591943 no 1941 0.399958553303355 2816 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1214 0358-0031 63.7 µM -0.25348001708467 0.426432104689125 no 1942 0.399948650552967 3129 4301366 SGTC_129 0088-0017 176.636 µM -0.253574518141934 0.426393999547237 no 1943 0.39991214244211 2956 182446 SGTC_1194 1488-0194 225 µM -0.255575429786413 0.425587344782356 no 1944 0.399139346308317 2832 1391452 SGTC_1786 berberine 21.6 µM -0.255990128631762 0.425420200428312 no 1945 0.398979229815892 2854 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1871 st057448 67.3 µM -0.256291187502919 0.425298867056524 no 1946 0.398863000712124 3047 691747 SGTC_2257 7960413 200 µM -0.257260110744395 0.424908417679253 no 1947 0.39848899167601 2858 2974689 YIL048W NEO1 SGTC_751 0833-0568 350 µM -0.258164634629249 0.424543985934473 no 1948 0.398139925223425 2934 6954252 SGTC_2210 7115885 190.385 µM -0.259170143482209 0.424138943157185 no 1949 0.397751983150413 2873 2927039 SGTC_1477 0139-0234 16 µM -0.259265539994931 0.424100519337142 no 1950 0.39771518283025 2858 620880 SGTC_2190 6049624 200 µM -0.259475518520469 0.424015946701003 no 1951 0.397634184365928 2913 2265554 SGTC_1672 st016598 6.51 µM -0.259601639279196 0.423965150973857 no 1952 0.397585535855999 2912 4665860 YNL267W PIK1 SGTC_208 k072-0098 12.366 µM -0.260674711814419 0.423533017156861 no 1953 0.397171684515833 2850 5948901 SGTC_3140 9094243 49.47 µM -0.260840687772542 0.423466185675825 no 1954 0.397107682977213 2840 19291112 SGTC_828 2074-0507 139 µM -0.262851475266757 0.422656702271894 no 1955 0.39633252927342 3005 X828 SGTC_916 4466-0038 42 nM -0.264518886522534 0.42198569942581 no 1956 0.395690056796648 3055 5722064 YGL116W CDC20 SGTC_659 k018-0002 107 µM -0.265204106024773 0.421710017601828 no 1957 0.395426115987388 3004 6797879 YHR007C ERG11 SGTC_1882 5615643 20 µM -0.265330010452125 0.421659367108324 no 1958 0.39537762386954 2867 2253075 SGTC_2180 6301957 200 µM -0.266365309921769 0.421242922404366 no 1959 0.394978939542851 2994 845462 SGTC_1525 8-methoxypsoralen 92.5 µM -0.266999026278544 0.420988056192279 no 1960 0.394734955401333 3138 4114 Related to psoralen; DNA damaging agent. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.267001414199228 0.420987095887791 no 1961 0.394734036117277 2890 390807 SGTC_1127 asiatic acid 681.4 nM -0.268794462560343 0.420266152946285 no 1962 0.394043927407781 2858 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1131 3454-3128 32.3 µM -0.272233120642004 0.418884298876834 no 1963 0.392721388297661 3039 710982 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.272289112524973 0.418861806290927 no 1964 0.392699863510934 2869 442882 SGTC_1712 st032288 53.4 µM -0.272697128421052 0.418697909607016 no 1965 0.392543021132089 2972 2883011 SGTC_2048 5246248 200 µM -0.273554905316464 0.418353393619616 no 1966 0.392213346381256 3002 677046 SGTC_719 2810-4230 27.3 µM -0.274285728912312 0.418059916327755 no 1967 0.391932525400311 2865 721079 SGTC_2394 5221648 200 µM -0.274928833946134 0.417801701962543 no 1968 0.39168545707183 3020 788586 SGTC_134 0269-0018 6.916 µM -0.275292455369107 0.417655719284799 no 1969 0.391545780184446 2964 4378915 SGTC_1136 pergolide 1.05886 µM -0.275830922910799 0.417439562184352 no 1970 0.391338965829938 2891 47811 A dopamine receptor agonist. SGTC_1850 st056238 17 µM -0.27621693768106 0.417284619569561 no 1971 0.391190724361215 2850 5393177 SGTC_1155 4088-0394 48.2 µM -0.276726062671975 0.417080281341699 no 1972 0.390995228978809 2853 2326248 SGTC_2623 humulene 100 µM -0.277522711846287 0.416760589727059 no 1973 0.390689384455685 2986 6187145 An anti-inflammatory. SGTC_1797 st048695 56.8 µM -0.279149688647065 0.416107862698727 no 1974 0.390064976023454 3031 592262 YIL048W NEO1 SGTC_1982 st072467 71.9 µM -0.280660218852747 0.4155020599276 no 1975 0.389485511764408 2853 3163533 SGTC_3235 9132602 49.47 µM -0.280978116040985 0.415374591812554 no 1976 0.3893635924116 3003 4912240 SGTC_313 3474-0040 5.03 µM -0.282169681405913 0.414896885909082 no 1977 0.388906702423115 2883 1043375 YIL048W NEO1 SGTC_1289 0976-0073 69.1 µM -0.282334348385546 0.41483087978005 no 1978 0.388843575112235 3011 3391136 SGTC_366 0181-0206 4.31 µM -0.282508495047517 0.414761076372644 no 1979 0.388776816830202 3093 274874 SGTC_1474 0330-0125 5.35 µM -0.282637978448514 0.414709177136015 no 1980 0.388727182122336 2939 X1474 SGTC_841 0251-0215 91.2 µM -0.284303519043839 0.414041732060488 no 1981 0.388088894781529 2954 3888614 SGTC_2038 4100038 30.985 µM -0.285892924635453 0.413405028561747 no 1982 0.387480066502683 3007 3596803 SGTC_1452 4194-0072 190 µM -0.285928270384624 0.413390871911381 no 1983 0.387466530308246 3068 1343545 SGTC_666 0272-0154 136 µM -0.28676871293512 0.413054291760497 no 1984 0.387144710331951 2954 6870312 SGTC_2718 lomofungin 53.02 µM -0.287199645712204 0.412881736712564 no 1985 0.386979728788726 3076 5351222 A RNA synthesis inhibitor. SGTC_2782 7736369 71.43 µM -0.288110413326202 0.412517100563782 no 1986 0.386631110880752 2964 2950836 YOL077C BRX1 SGTC_940 3232-1287 54.8 µM -0.289001991357062 0.412160220298211 no 1987 0.386289926834571 2933 1585493 YIL048W NEO1 SGTC_1749 st037932 54.2 µM -0.291647406459829 0.411101743815853 no 1988 0.385278112615476 3049 594497 SGTC_1373 2887-0003 58.5 µM -0.291970187876 0.410972637497135 no 1989 0.385154708971628 2986 776948 SGTC_3082 9117008 49.47 µM -0.292415564136166 0.410794511448984 no 1990 0.384984454778458 2945 41448529 SGTC_2497 7-hydroxyflavone 100 µM -0.292427612089637 0.410789693184526 no 1991 0.384979849509455 3089 5281894 SGTC_2777 climbazole 1.536 µM -0.293286368922666 0.410446290526252 no 1992 0.384651635904609 3002 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3055 9094636 49.47 µM -0.294016731662054 0.410154284550814 no 1993 0.384372559067985 3096 25236176 SGTC_429 1112-0049 25.5 µM -0.295165733547279 0.409695003538049 no 1994 0.383933638552748 2894 2836170 SGTC_475 α-linolenic acid 10 µM -0.29607160521816 0.409332994259132 no 1995 0.383587699057985 3151 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1211 1056-0033 32.3 µM -0.296977947818176 0.408970874145497 no 1996 0.38324167256401 3072 6741922 SGTC_109 0132-0036 33.701 µM -0.30001193562991 0.407759241618829 no 1997 0.38208402571538 2884 67274 A color developer. SGTC_2106 5357045 167.29 µM -0.300230453007824 0.407672009921719 no 1998 0.38200068888078 3019 668842 SGTC_2423 st077119 87.2 µM -0.300622636132223 0.407515462690896 no 1999 0.381851134168933 2926 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_206 4546-0025 72.014 µM -0.301089438310809 0.407329149121097 no 2000 0.38167314728738 2995 6620745 YIL048W NEO1 SGTC_3131 9127911 49.47 µM -0.301488629141236 0.407169837724385 no 2001 0.381520959759855 3173 45595681 SGTC_524 r073-0010 27.8 µM -0.304726404315531 0.405878257180778 no 2002 0.380287268862039 2918 2772106 SGTC_1285 0929-0069 65.5 µM -0.305820162420162 0.405442176901808 no 2003 0.379870788054412 2966 1206237 SGTC_2426 5582046 32.21 µM -0.305973847571255 0.40538091217384 no 2004 0.379812279029562 3130 2251934 SGTC_3250 9135583 49.47 µM -0.30762131702996 0.404724314299887 no 2005 0.379185248823921 3086 7699353 SGTC_569 4130-2812 160 µM -0.307858779466009 0.404629695871783 no 2006 0.379094896300777 2947 743552 SGTC_3108 9121785 49.47 µM -0.308704366103102 0.404292811784227 no 2007 0.378773211139461 2864 17140271 SGTC_1027 k015-0025 8.67 µM -0.310207629706047 0.403694082693944 no 2008 0.378201534432922 2928 3598955 SGTC_1009 4106-0057 9.87 µM -0.310779727641607 0.403466283193433 no 2009 0.377984041037333 3110 2928005 SGTC_936 3005-4620 401 µM -0.31097078994247 0.403390212781507 no 2010 0.377911413851696 3161 777207 SGTC_167 3672-0051 66.205 µM -0.311277720185259 0.403268017834669 no 2011 0.377794751624581 2891 3237971 SGTC_1760 st045453 10.4495 µM -0.312140902281918 0.402924418784849 no 2012 0.37746672139599 3082 3323419 YIL048W NEO1 SGTC_1815 st051655 58.2 µM -0.313539812417184 0.402367726618063 no 2013 0.376935289217183 3056 5984156 SGTC_171 k064-0041 9.68 µM -0.314143929731003 0.402127381045959 no 2014 0.376705862996268 2973 53325 SGTC_1960 st011366 51.8 µM -0.315057417377309 0.401764024071358 no 2015 0.376359029614845 2941 3972846 SGTC_3305 9127027 53.8275 µM -0.318083393634559 0.400560992919984 no 2016 0.375210839968093 2988 41905295 SGTC_2784 7567673 72.73 µM -0.318161942673405 0.40052977684413 no 2017 0.375181049645994 2956 3471247 SGTC_2528 xanthyletin 44.79 µM -0.319319933021663 0.400069655161096 no 2018 0.374741959451179 2956 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2195 6536160 144.242 µM -0.319541172980863 0.399981762328592 no 2019 0.374658087484775 2944 3834386 SGTC_246 cycloheximide 667 µM -0.319816530080237 0.399872377253404 no 2020 0.374553708017931 2950 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1147 3809-1045 12.3 µM -0.320077462830557 0.39976872947282 no 2021 0.374454804863182 2987 325925 SGTC_2642 cholecalciferol 100 µM -0.320469571340095 0.399612989301995 no 2022 0.374306196782478 3063 9821465 A vitamin D precursor, similar to steriods. SGTC_2541 muurolladie-3-one 83.07 µM -0.320849872067013 0.399461954278282 no 2023 0.374162081657497 3133 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3316 9136639 10.545 µM -0.320915960090045 0.399435709198765 no 2024 0.3741370393654 3069 4903665 SGTC_2720 fluspirilene 36.88 µM -0.321939543072369 0.399029278865415 no 2025 0.373749247794557 3056 3396 An atypical antipsychotic. SGTC_3299 9121982 43.1275 µM -0.322421816571327 0.398837822202157 no 2026 0.373566579366436 2986 17594604 YPL160W CDC60 SGTC_777 1315-0167 517 µM -0.323330991452475 0.39847695715143 no 2027 0.373222292813277 3058 4221767 SGTC_1888 azatryptophan 97.5 µM -0.325281124471228 0.397703213427283 no 2028 0.372484157632684 3085 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2194 5927483 104.545 µM -0.325302188947742 0.397694857979433 no 2029 0.372476187172904 2968 760979 SGTC_2871 9038510 12.99 µM -0.325783606912858 0.397503911241828 no 2030 0.372294041236872 3183 4945164 SGTC_3238 9133470 49.47 µM -0.326036056651892 0.397403790902079 no 2031 0.372198537532997 3122 3534688 SGTC_404 fumagillin 50 µM -0.326144727863037 0.397360694508461 no 2032 0.3721574287866 3036 12015870 A methionine aminopeptidase binder. SGTC_640 3381-0960 37.1 µM -0.327489878647133 0.396827343900428 no 2033 0.371648698484646 3045 1745025 SGTC_2134 5324836 1.464 µM -0.328363116911981 0.396481209233813 no 2034 0.371318563376405 2990 699272 SGTC_1931 st074438 57.1 µM -0.328727082165758 0.396336964553449 no 2035 0.371180991168581 2963 2787313 SGTC_2117 5521686 200 µM -0.330816028684338 0.39550935989847 no 2036 0.370391726411276 2969 803312 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.331596634200978 0.395200218110143 no 2037 0.370096930718631 3126 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.332648422418403 0.394783784653034 no 2038 0.369699843560821 2968 803109 SGTC_305 1682-2595 20.8 µM -0.333124884188749 0.394595179144903 no 2039 0.3695200081252 3054 226033 SGTC_2725 haloperidol 53.21 µM -0.33372927696599 0.394355968202709 no 2040 0.369291927559637 2980 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1827 berberine 7.24 µM -0.334282641151838 0.394136988656677 no 2041 0.369083144062998 2986 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3159 9100096 49.47 µM -0.335140036694694 0.393797762683444 no 2042 0.368759726272935 2903 25236875 SGTC_172 1112-0046 2.638 µM -0.336840617577309 0.393125171585458 no 2043 0.368118526044324 3013 2802135 YIL048W NEO1 SGTC_298 1391-0729 10 µM -0.337765898176254 0.392759350755316 no 2044 0.367769805198647 2990 3237558 SGTC_840 0245-0196 390 µM -0.337766052229292 0.392759289856468 no 2045 0.367769747148022 3135 3827528 SGTC_850 0388-0143 75.9 µM -0.338390769459892 0.392512353923347 no 2046 0.36753436459806 3003 67273 SGTC_762 1165-0429 115 µM -0.339140119578927 0.392216210642619 no 2047 0.367252088191549 3126 5967793 SGTC_1028 k015-0029 4.8 µM -0.340086925211618 0.391842122183851 no 2048 0.366895533875203 2985 4588309 SGTC_2343 7990716 14.84 µM -0.340165796613621 0.391810964136468 no 2049 0.366865837137467 2974 6456862 SGTC_1968 st069590 43.6 µM -0.340576776822345 0.391648618158612 no 2050 0.366711107361664 3127 6384066 SGTC_1511 0906-3109 28.5 µM -0.342465969439059 0.390902589765321 no 2051 0.366000124915089 3007 2882180 SGTC_53 0973-0023 39.979 µM -0.342677746497645 0.390818985513884 no 2052 0.36592045294453 3137 674768 SGTC_1301 naphtanilide LB 4.81 µM -0.342950855775429 0.39071117629692 no 2053 0.365817715911978 3131 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1294 1000-1494 117 µM -0.344210176262533 0.390214171418098 no 2054 0.365344114918375 3051 712797 YDL207W GLE1 SGTC_1801 st050089 28.441 µM -0.345133478551216 0.389849893793715 no 2055 0.364997012882312 3016 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1152 3909-8331 15.9 µM -0.345747977443648 0.389607504362782 no 2056 0.36476606226004 3046 16001939 SGTC_1081 sertraline 6 µM -0.348975100205536 0.388335270840329 no 2057 0.363554001497679 3137 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_342 k048-0088 23.3 µM -0.349161606782175 0.388261780532679 no 2058 0.363483993911528 2998 6820570 SGTC_1193 1488-0126 41.5 µM -0.349162059390086 0.388261602193728 no 2059 0.363483824025008 3040 1384710 SGTC_1196 1588-0294 184 µM -0.349915121061222 0.387964909527946 no 2060 0.363201199299874 3072 6144269 SGTC_1434 4073-0095 163 µM -0.349948781013116 0.387951649641608 no 2061 0.36318856842705 3080 24133745 SGTC_854 0422-0053 192 µM -0.350291853146627 0.387816508432765 no 2062 0.363059839343162 3053 3596728 SGTC_65 0798-0905 34.986 µM -0.351249749317882 0.387439250883119 no 2063 0.362700495127495 3407 3602145 SGTC_446 go6976 132 µM -0.351577262235802 0.387310287650435 no 2064 0.362577659974713 3145 3501 A protein kinase C inhibitor. SGTC_2460 5552655 174.22 µM -0.352355725583898 0.387003805703344 no 2065 0.362285750671595 3145 5401989 SGTC_1966 st070145 16.1 µM -0.353476997236254 0.386562483556263 no 2066 0.361865435362333 2950 3748532 SGTC_2232 chlorophetanol 41.5365 µM -0.353710040935082 0.386470778104341 no 2067 0.361778098444246 3116 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_64 000l-0018 272.079 µM -0.354330463027976 0.386226665594584 no 2068 0.361545620275035 2968 6811119 SGTC_1851 st056236 18.9 µM -0.355535237507095 0.38575276133483 no 2069 0.361094325637731 3198 5393171 SGTC_3067 9117431 49.47 µM -0.356968870553966 0.385189056543344 no 2070 0.360557555087386 3057 17150885 SGTC_897 1000-0139 31.4 µM -0.357382298187992 0.385026541717329 no 2071 0.360402813468306 3184 6151020 SGTC_3070 9117005 49.47 µM -0.35758739060287 0.384945929155336 no 2072 0.360326058014745 3106 8779016 SGTC_1581 himbacine 57.9 µM -0.357623150803995 0.384931873944987 no 2073 0.360312675402422 3021 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1879 gemcitabine 100 µM -0.359325651403802 0.384262897379814 no 2074 0.359675743463394 3047 60750 A nucleoside analog which inhibits DNA replication. SGTC_2019 4016004 108 µM -0.359966035712686 0.384011355363424 no 2075 0.359436266466877 3110 45595336 SGTC_3210 9128157 49.47 µM -0.362161200803963 0.383149469097291 no 2076 0.358615785790613 3112 17590849 SGTC_1020 4335-0961 93.3 µM -0.363389326216926 0.38266752290804 no 2077 0.358157037030036 2998 669075 SGTC_536 3852-0578 10.6 µM -0.363522327193514 0.382615340987576 no 2078 0.358107368682081 3189 2869208 SGTC_642 0335-0876 158 µM -0.364731468105366 0.382141041620274 no 2079 0.357655933134286 3053 6812350 SGTC_1650 st011916 45.8 µM -0.366472392534343 0.381458454784573 no 2080 0.357006304736423 3185 242528 SGTC_1415 3966-0071 78.1 µM -0.366642075214489 0.381391944770573 no 2081 0.356943009538231 3121 2893185 SGTC_2536 dehydroabietamide 32.04 µM -0.366851062294014 0.381310033542032 no 2082 0.356865058386397 3185 3983547 SGTC_673 1082-0474 110 µM -0.370190082331695 0.380002048093883 no 2083 0.355620432836831 3088 3098046 SGTC_1755 st041960 45.185 µM -0.371545658809097 0.37947142225463 no 2084 0.355115577463172 3175 2257073 SGTC_42 0133-0086 60.653 µM -0.372135459368806 0.379240621956937 no 2085 0.354895998216733 2982 162923 Model of phenazepam hydroxylation. SGTC_2265 7929201 200 µM -0.373821136692783 0.378581221538222 no 2086 0.354268696460874 2993 1265108 SGTC_1405 3909-7894 12 µM -0.373923987313354 0.378541000023914 no 2087 0.354230434784822 3148 7104060 SGTC_1907 st060210 83.7 µM -0.374086361082091 0.378477503631304 no 2088 0.354170032772389 3206 688793 SGTC_356 1634-0012 32.5 µM -0.3744640994083 0.378329801452747 no 2089 0.35402953070757 3183 735457 SGTC_2040 5100729 123 µM -0.377383014838253 0.37718905627861 no 2090 0.352944493780319 3049 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2132 5317594 122.667 µM -0.377850278578496 0.377006543503244 no 2091 0.352770910385518 3033 794577 SGTC_284 0988-0104 32.6 µM -0.378219838282218 0.376862213289749 no 2092 0.352633644678288 3141 4666532 SGTC_2517 totarol 10 µM -0.380074047045661 0.376138318841032 no 2093 0.351945225114261 3167 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_875 0709-0210 25.7 µM -0.38060841697351 0.375929778288788 no 2094 0.35174691737196 3216 6251364 SGTC_3237 9133362 49.47 µM -0.380648091507101 0.375914296546547 no 2095 0.351732195532875 3160 43845137 SGTC_3355 9151058 44.0485 µM -0.382420680488824 0.375222803448356 no 2096 0.35107467659303 3158 17015728 SGTC_2468 5987765 72.9 µM -0.382604217014218 0.375151228074731 no 2097 0.35100662151999 3111 26772094 SGTC_1325 1431-0015 227 µM -0.383039317115772 0.374981565391411 no 2098 0.350845306140045 3073 1103340 SGTC_2712 st079126 47.7 µM -0.383425018411166 0.37483118547477 no 2099 0.350702328073447 3059 3152970 SGTC_3319 9138450 16.7555 µM -0.383872919041624 0.374656578728283 no 2100 0.350536319473344 3060 2029690 SGTC_122 0236-0016 402.397 µM -0.384926466089398 0.374245971978744 no 2101 0.350145948400206 3120 6808838 SGTC_1518 st038567 90.8 µM -0.385674069326552 0.373954689464021 no 2102 0.349869034755823 3158 77966 SGTC_2166 5933061 31.504 µM -0.385732031147191 0.373932109279239 no 2103 0.34984756892141 3523 2877375 SGTC_701 4424-0219 185 µM -0.385757006213168 0.373922379876871 no 2104 0.34983831969408 3248 2911779 SGTC_3331 9141060 1.957 µM -0.385946130203675 0.373848706466872 no 2105 0.349768282700401 3069 4906567 YPR165W RHO1 SGTC_1651 st011928 86.1 µM -0.386415262822102 0.373665975359932 no 2106 0.349594574098991 3176 720198 SGTC_1228 0124-0032 52.5 µM -0.386450877151178 0.37365210443792 no 2107 0.349581388249228 3157 X1228 SGTC_349 k015-0014 24 µM -0.387389364056853 0.373286645459841 no 2108 0.349233988285548 3020 2196908 SGTC_1898 st060199 18.6 µM -0.388255724291528 0.372949374689812 no 2109 0.348913399559374 3071 688866 SGTC_245 methotrexate 289.6 µM -0.388455447933322 0.372871636829101 no 2110 0.348839508927323 3159 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_68 0986-0284 82.829 µM -0.390214391948963 0.372187231968579 no 2111 0.348189010139606 3230 423278 YIL048W NEO1 SGTC_545 4218-0007 221 µM -0.390582219859286 0.372044161128904 no 2112 0.348053035113514 3209 2840508 SGTC_49 0717-0965 32.132 µM -0.39069958826489 0.371998513072208 no 2113 0.348009651618828 3336 5889349 YGL099W LSG1 SGTC_126 0417-1624 672.48 µM -0.390779425519904 0.371967463022052 no 2114 0.347980142095504 3220 41912 YDL195W SEC31 SGTC_2108 5365811 200 µM -0.392131102900456 0.371441899504171 no 2115 0.347480673664613 3198 780283 SGTC_1494 4358-1428 177 µM -0.393884635774738 0.370760442376771 no 2116 0.346833107105042 3232 1564571 SGTC_2143 5623677 140.463 µM -0.394719918219529 0.370435977648316 no 2117 0.346524800664766 3184 5375313 SGTC_1272 0839-0021 27 µM -0.395023807389887 0.370317955017795 no 2118 0.34641265903395 3171 5027250 SGTC_2416 tofa 880 nM -0.395155316331347 0.370266884157498 no 2119 0.346364133582598 3089 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2259 7964009 200 µM -0.395236385384659 0.37023540252276 no 2120 0.346334221189248 3244 313134 SGTC_1262 0737-0114 49.6 µM -0.395930651723102 0.369965832928866 no 2121 0.346078094052369 3266 765919 SGTC_1956 st077085 54 µM -0.396126364130202 0.369889853290417 no 2122 0.346005904996989 3125 24208685 SGTC_2071 5230951 39.92 µM -0.39647155049694 0.369755857122683 no 2123 0.345878595705038 3198 1799272 SGTC_1660 st012960 28.1 µM -0.396494719854347 0.369746863691973 no 2124 0.345870051163754 3182 24207266 SGTC_1395 3486-0190 4.35 µM -0.396845943415403 0.369610541287173 no 2125 0.345740534346812 3271 6748079 SGTC_2161 5662504 8.5105 µM -0.397186184583712 0.369478497168448 no 2126 0.345615084598075 3116 2859334 SGTC_1161 k007-0610 110 µM -0.397496619574204 0.369358033952128 no 2127 0.345500639424196 3234 5843850 SGTC_526 4469-0568 170 µM -0.397608769481848 0.369314517724389 no 2128 0.345459297635082 3102 2901964 SGTC_2864 9034755 47.6 µM -0.398456092112451 0.368985795104688 no 2129 0.345147008939739 3188 4930451 SGTC_2887 9044784 58.44 µM -0.398867405617631 0.36882625870931 no 2130 0.344995453488023 3102 6465546 SGTC_2400 5203494 178.7 µM -0.400140309452252 0.3683326801061 no 2131 0.344526588058159 3137 6777674 SGTC_332 4112-0506 40.9 µM -0.404908431495335 0.366485739498176 no 2132 0.342772410245558 3119 2790355 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.405011937863691 0.366445680212037 no 2133 0.342734367963319 3119 5355888 SGTC_1154 4088-0362 150 µM -0.405083239387338 0.366418085769522 no 2134 0.342708163037831 3085 6618304 SGTC_55 0767-0285 6.563 µM -0.40560299217953 0.366216956824713 no 2135 0.34251716498459 3217 3116166 SGTC_47 0149-0135 24.25 µM -0.405671238222134 0.366190550354703 no 2136 0.34249208901049 3098 5239155 SGTC_259 usnic acid 108.925 µM -0.405757186625206 0.366157295204463 no 2137 0.342460509560023 3316 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2963 9082507 9 µM -0.409812370014082 0.364589410578823 no 2138 0.340971795657218 3261 16459611 SGTC_2465 5809242 33.21 µM -0.410343369230646 0.364384273511341 no 2139 0.340777041102247 3141 2731748 SGTC_2083 5306046 65.942 µM -0.411005463417817 0.364128545885334 no 2140 0.340534264294167 3159 539837 SGTC_1519 esterone 74 µM -0.411347175875097 0.363996586333508 no 2141 0.340408990951015 3094 698 A steroid. SGTC_1560 lithocholic acid 53.1 µM -0.412284578383459 0.363634671202179 no 2142 0.340065425361069 3200 9903 A bile acid which acts as a detergent. SGTC_2058 5236698 133 µM -0.412999399171482 0.363358772812302 no 2143 0.339803526969832 3143 766665 SGTC_3151 9099821 49.47 µM -0.41320449860308 0.363279623946656 no 2144 0.339728396233358 3223 17174189 SGTC_715 0868-0130 184 µM -0.41396748243098 0.36298523605846 no 2145 0.339448960705463 3282 2876258 SGTC_156 3474-0145 5.642 µM -0.414368052192416 0.362830713553987 no 2146 0.339302291180167 3253 2265471 SGTC_1438 4092-1045 4 µM -0.415729693442108 0.362305618318639 no 2147 0.338803905282525 3140 1351342 SGTC_2211 7117706 200 µM -0.415732246877782 0.362304633869863 no 2148 0.338802970942521 3223 822771 SGTC_3199 9111318 49.47 µM -0.416845150740059 0.361875652915171 no 2149 0.338395837396637 3206 8548020 SGTC_2490 carminic acid 95.39 µM -0.417566976396815 0.361597510045433 no 2150 0.338131872893518 3228 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_603 3794-0023 45.9 µM -0.418040628840397 0.361415036094992 no 2151 0.337958706098739 3225 3802260 SGTC_2546 rhodinyl acetate 100 µM -0.418420432596771 0.361268739989841 no 2152 0.337819875043751 3264 6708682 SGTC_2788 5282734 71.43 µM -0.418698572418019 0.36116161654725 no 2153 0.337718219571085 3284 743706 SGTC_3130 9127414 49.47 µM -0.419070976782637 0.361018204878539 no 2154 0.337582130514344 3221 1494646 SGTC_2968 9090663 33.37 µM -0.419388858893608 0.360895804999883 no 2155 0.337465982519548 3159 25236811 SGTC_227 fluconazole 33.516 µM -0.421162387162942 0.36021317320707 no 2156 0.336818253924915 3187 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.421636759553127 0.360030662485715 no 2157 0.336645085390888 3224 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2560 caryophyllene 100 µM -0.421664159051968 0.360020121736973 no 2158 0.336635084325415 3134 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1197 1601-0112 267 µM -0.422869237186105 0.359556626464406 no 2159 0.336195334265293 3121 7350313 SGTC_2724 maprotiline 69.64 µM -0.42362192590839 0.359267233238797 no 2160 0.335920781135005 3281 4011 A tricyclic antidepressant. SGTC_104 0074-0074 590.992 µM -0.423685797495572 0.359242679649492 no 2161 0.335897487158994 3163 3943124 SGTC_378 3970-0959 8.33 µM -0.42381176421231 0.359194257082619 no 2162 0.335851548928866 3245 6615653 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.42499708740636 0.358738720675723 no 2163 0.335419398987528 3187 2346 DNA damaging agent; causes G2/M arrest. SGTC_1252 0493-0875 34.8 µM -0.425215624406917 0.358654755738752 no 2164 0.335339747628606 3123 3960963 SGTC_1284 0929-0043 16 µM -0.427674933535422 0.357710327027387 no 2165 0.334443901004338 3205 1239883 SGTC_1802 st050112 57.9 µM -0.428048766569558 0.357566843008075 no 2166 0.33430780809007 3191 4662563 SGTC_1761 st044296 37 µM -0.428820646538355 0.357270644936197 no 2167 0.334026876172221 3122 1826700 SGTC_1312 1218-2183 165 µM -0.429012162275429 0.357197166774383 no 2168 0.333957186871049 3249 6744073 SGTC_1919 st067113 52.3 µM -0.43035509921577 0.356682075824514 no 2169 0.333468676043878 3271 1268243 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.430983813735861 0.356441018588022 no 2170 0.333240069893954 3277 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2201 6605497 169.863 µM -0.43276051894264 0.355760117218883 no 2171 0.332594379258625 3204 670741 SGTC_1910 st062352 60.4 µM -0.433531526922358 0.35546478045145 no 2172 0.332314333663003 3108 2245730 SGTC_786 4544-0069 423 µM -0.434394235092426 0.355134420532745 no 2173 0.332001091671705 3242 748821 YLR208W SEC13 SGTC_3348 9149464 3.537 µM -0.436410149483121 0.354362883996105 no 2174 0.331269588205895 3207 1951442 SGTC_1703 st026983 48.3 µM -0.437316340439542 0.354016258396633 no 2175 0.330940973241564 3308 1104023 SGTC_1880 MG-132 525 µM -0.439459710948322 0.353196883084366 no 2176 0.330164234421669 3285 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_374 0880-0231 82.3 µM -0.440021482969932 0.352982239205864 no 2177 0.329960773964573 3220 6833587 SGTC_2379 9035213 200 µM -0.441092956761492 0.352572976374717 no 2178 0.329572851125573 3308 646551 SGTC_440 fluspirilene 35.1 µM -0.443276344742353 0.351739532416945 no 2179 0.328782931861098 3365 3396 An atypical antipsychotic. SGTC_253 dyclonine 31.25 µM -0.444019138457036 0.351456154943704 no 2180 0.328514373525055 3267 3180 An oral anasthetic. SGTC_1747 st037496 66.6 µM -0.44447537619589 0.351282140128252 no 2181 0.328349463886659 3168 723305 SGTC_1249 0481-0015 10.2 µM -0.444963709619195 0.351095918153327 no 2182 0.328172990136689 3129 4227577 SGTC_2470 5664817 21.68 µM -0.445992087405177 0.350703871624994 no 2183 0.327801480788561 3261 2859561 SGTC_1952 st077036 64.1 µM -0.44608486886497 0.350668508534019 no 2184 0.327767971149264 3251 2937007 SGTC_2261 9010538 184.68 µM -0.448809601502955 0.349630571308019 no 2185 0.326784505910256 3281 6457250 SGTC_511 blebbistatin 171 µM -0.448965972552782 0.349571038609654 no 2186 0.326728101742572 3337 3476986 A myosin inhibitor. SGTC_3135 9127742 49.47 µM -0.451131262148849 0.348747062705388 no 2187 0.325947473662806 3219 3643468 SGTC_2024 5144227 134 µM -0.453496398213218 0.347847852189721 no 2188 0.325095668164249 3306 3475211 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.454730441181077 0.347379015609138 no 2189 0.324651588956969 3367 16725076 SGTC_3005 9076496 71.4286 µM -0.455606432497597 0.347046351318223 no 2190 0.324336508360868 3294 21368410 SGTC_578 3460-0051 92 µM -0.455652134147064 0.347028999005275 no 2191 0.324320073629935 3349 2876744 SGTC_1748 st037455 53.6035 µM -0.456067035588962 0.346871481083601 no 2192 0.324170886938666 3345 580690 SGTC_1369 1866-0067 208 µM -0.456371356700737 0.346755961961969 no 2193 0.32406147971486 3343 3531355 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.456806310991446 0.346590879721265 no 2194 0.323905134617639 3297 17037758 SGTC_1426 4048-4480 71.7 µM -0.458430083390527 0.345974851873609 no 2195 0.323321741339618 3314 14224343 SGTC_330 1488-0319 80.1 µM -0.459695976356299 0.345494879094996 no 2196 0.322867229012635 3273 6846614 SGTC_684 1140-0066 328 µM -0.460852500772111 0.345056591243122 no 2197 0.32245221601938 3289 6813534 SGTC_2704 st078022 71.1 µM -0.461071715584493 0.344973538851469 no 2198 0.322373576799145 3353 54697681 SGTC_2694 st077685 81.9 µM -0.462006787635648 0.344619358516579 no 2199 0.322038226456562 3133 2838096 SGTC_41 0478-0632 82.643 µM -0.463333146254838 0.344117202878098 no 2200 0.321562795225958 3343 3750424 SGTC_427 1354-0053 47.3 µM -0.463974478121113 0.343874494927176 no 2201 0.321333015513142 3384 6813657 SGTC_2217 6934799 96.0675 µM -0.464115318739284 0.343821203304788 no 2202 0.321282563557212 3290 675606 SGTC_1950 st077106 7.18 µM -0.464600786465477 0.343637534609672 no 2203 0.321108684485279 3264 13831864 SGTC_1064 honokiol 6.76 µM -0.465237624880389 0.343396653280917 no 2204 0.320880648721055 3279 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1149 3909-7961 23.3 µM -0.466440004424677 0.342942031959488 no 2205 0.320450291183922 3255 735261 SGTC_1182 1222-0449 220 µM -0.467135797182418 0.342679055559724 no 2206 0.320201362154614 3287 658318 SGTC_1436 4092-1007 8.32 µM -0.46773712918602 0.342451842206721 no 2207 0.319986292869597 3223 2881121 SGTC_551 k048-0028 34.9 µM -0.469646091175316 0.341730918801276 no 2208 0.319303944490101 3351 6836383 SGTC_3171 9103192 49.47 µM -0.470166636933407 0.341534433615601 no 2209 0.319117984181095 3350 13018434 SGTC_59 0330-0160 1.33 µM -0.470400785424628 0.341446065930411 no 2210 0.319034351566355 3322 4293482 SGTC_2062 5245942 200 µM -0.470833321118615 0.341282849737103 no 2211 0.318879883697254 3325 1376160 SGTC_2714 st079313 56.9 µM -0.471282681793668 0.341113316122147 no 2212 0.318719440576752 3236 2939799 SGTC_1983 st071813 46.9 µM -0.47138891085876 0.341073242985193 no 2213 0.318681516715293 3275 11838595 SGTC_2336 9001819 198.65 µM -0.47214755087479 0.340787110873906 no 2214 0.318410736847714 3429 2989602 SGTC_3042 9091578 49.47 µM -0.472167038251298 0.340779762132249 no 2215 0.318403782534255 3314 25236497 SGTC_1557 sumaresinolic acid 42.3 µM -0.473136993269716 0.340414065910039 no 2216 0.31805772288046 3235 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2841 9004761 38.96 µM -0.473770945358341 0.340175131860188 no 2217 0.317831627826212 3235 2991039 SGTC_3058 9093861 49.47 µM -0.474643185527999 0.339846492854299 no 2218 0.317520659804856 3381 17217477 SGTC_2256 7954252 200 µM -0.477370892208147 0.338819545173327 no 2219 0.316549018831025 3296 2972920 SGTC_480 am 92016 50 µM -0.479091974626603 0.338172194325413 no 2220 0.315936599392655 3288 2129 K+ channel blocker. SGTC_1743 st037606 46.3785 µM -0.479778822915329 0.337913983404952 no 2221 0.315692336338067 3238 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_139 0099-0334 718.624 µM -0.48077519595664 0.337539546581472 no 2222 0.315338140434841 3292 97690 SGTC_1790 st045711 43.5 µM -0.483315595653951 0.336585593100197 no 2223 0.314435834093141 3407 585119 SGTC_3203 9113543 49.47 µM -0.484510891660425 0.336137106839037 no 2224 0.314011668238494 3344 17018012 SGTC_2208 7283366 200 µM -0.485388212207105 0.335808076268507 no 2225 0.313700496231162 3354 898663 SGTC_1318 1280-3875 124 µM -0.48558043478036 0.335736001849706 no 2226 0.313632335549201 3311 373245 SGTC_1384 3089-0840 101 µM -0.485626384057216 0.33571877392797 no 2227 0.313616043222504 3345 1069836 SGTC_3078 9116413 49.47 µM -0.486470728206573 0.335402262545252 no 2228 0.313316727179242 3231 17177322 SGTC_1865 st057639 52.2 µM -0.486649879598669 0.335335120752242 no 2229 0.31325323465215 3290 688818 SGTC_3040 9091894 49.47 µM -0.486873433983116 0.335251345122327 no 2230 0.313174013152258 3243 25236966 SGTC_1697 st025554 27.742 µM -0.48709449250465 0.335168512858039 no 2231 0.313095684595599 3250 1269519 SGTC_250 brefeldin a 552.239 µM -0.487187888749648 0.335133519001915 no 2232 0.313062593661926 3272 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_796 1234-0020 70.7 µM -0.487435799005192 0.335040638527131 no 2233 0.312974764651924 3313 46495034 SGTC_1617 st002906 78 µM -0.487938354655467 0.334852385187592 no 2234 0.312796753091045 3306 5150859 SGTC_507 nimesulide 162 µM -0.488498983959794 0.334642426882962 no 2235 0.31259822261247 3418 4495 A COX2 inhibitor. SGTC_3079 9117512 49.47 µM -0.489164301300689 0.334393329494533 no 2236 0.312362690468514 3342 7185044 SGTC_1884 5633444 25 µM -0.489463473882756 0.334281341874929 no 2237 0.312256803940733 3370 5724239 SGTC_34 0469-0683 81.75 µM -0.489508286332144 0.334264568748148 no 2238 0.312240944749159 3325 3690923 SGTC_1270 0831-1170 17.3 µM -0.489662090738027 0.334207002870094 no 2239 0.312186515790467 3359 6764716 SGTC_2188 6126565 140.678 µM -0.489703995373178 0.334191319488672 no 2240 0.312171687110068 3350 874518 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.490999951250827 0.333706433350669 no 2241 0.311713241015317 3344 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1645 Cervolide 78 µM -0.491009825651018 0.333702739876131 no 2242 0.311709749051991 3319 23173 A fragrance. SGTC_2308 7584454 197.62 µM -0.491789955626188 0.333410986758441 no 2243 0.311433918961515 3441 893577 SGTC_2883 9059145 45.46 µM -0.49372588449267 0.332687423315268 no 2244 0.310749891073115 3215 16476510 SGTC_2618 avocadyne 43.43 µM -0.49387434028266 0.332631962871728 no 2245 0.310697463671092 3288 3015189 SGTC_2054 5233173 129 µM -0.494489946641441 0.332402022380122 no 2246 0.310480102317892 3366 6889 SGTC_1076 itraconazole 331 nM -0.494819932097409 0.332278792594595 no 2247 0.310363616644588 3339 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_18 0111-0177 500 nM -0.495895819184535 0.331877139247733 no 2248 0.309983958011301 3346 721752 SGTC_2072 5231554 129 µM -0.497731123638028 0.331192423904108 no 2249 0.309336783999683 3404 789545 SGTC_3166 9102297 49.47 µM -0.498957008069022 0.330735385005706 no 2250 0.308904835718021 3317 25237072 SGTC_775 4577-0580 57.3 µM -0.499068103475438 0.330693978448339 no 2251 0.30886570358091 3457 2006902 SGTC_669 0108-0021 26.2 µM -0.49907266050666 0.330692280033733 no 2252 0.308864098463016 3545 17201 SGTC_1691 st019933 84.6 µM -0.500815737220247 0.330042887827283 no 2253 0.308250404527329 3345 6176082 SGTC_58 0957-0393 9 µM -0.500932813853686 0.329999288644502 no 2254 0.308209203934163 3389 6997992 SGTC_627 1391-0720 175 µM -0.502307401102051 0.329487567014061 no 2255 0.307725651950816 3316 997839 SGTC_1336 1486-0901 104 µM -0.502322277834258 0.329482030553315 no 2256 0.30772042044182 3347 5006114 SGTC_1583 clindamycin 39.6 µM -0.503644101097507 0.328990255814775 no 2257 0.307255748018886 3276 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3218 9131285 49.47 µM -0.504791933851499 0.328563452931812 no 2258 0.306852490886997 3454 17156417 SGTC_2798 7813637 45.45 µM -0.505976981356384 0.328123046893662 no 2259 0.306436404525067 3386 956368 SGTC_1900 st060200 72.8 µM -0.507473440349352 0.327567250453388 no 2260 0.305911333729212 3272 688945 SGTC_821 1114-0266 29.2 µM -0.509778318316952 0.32671194833239 no 2261 0.305103388579902 3353 3123235 SGTC_1578 josamycin 24.2 µM -0.509787489345404 0.326708546929813 no 2262 0.305100175687484 3284 5282165 A P450 substrate. SGTC_2227 7312221 64.1025 µM -0.511163681106112 0.326198300571061 no 2263 0.30461822388382 3357 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_682 0kpi-0099 17 µM -0.511862151379837 0.325939455244491 no 2264 0.304373744413227 3388 1714895 YML126C ERG13 SGTC_1174 0739-0097 51.1 µM -0.512818093555503 0.325585329637367 no 2265 0.304039285960859 3327 728447 SGTC_3321 9137793 26.8275 µM -0.514246409121793 0.325056508153242 no 2266 0.303539862267231 3381 4904192 SGTC_24 0417-1663 219 µM -0.514416589183943 0.324993523920582 no 2267 0.303480381674544 3373 4329390 SGTC_1909 st060837 51.5 µM -0.516103982108942 0.324369284819672 no 2268 0.30289089343638 3299 678937 SGTC_2521 angolensin 13.4 µM -0.516291008925412 0.324300125903071 no 2269 0.302825587460346 3416 821428 A flavenoid. SGTC_2734 clemastine 41.6 µM -0.516321457100297 0.32428886732772 no 2270 0.302814956171215 3326 26987 Clemastine is a selective histamine H1 antagonist. SGTC_302 1094-0063 18.9 µM -0.516460304488222 0.324237528888834 no 2271 0.302766478316169 3283 5440289 SGTC_2145 5634607 200 µM -0.516928657702148 0.324064381229056 no 2272 0.30260298083107 3292 308662 SGTC_1406 3909-7906 11.9 µM -0.517720797068755 0.323771618191828 no 2273 0.302326542888906 3384 X1406 SGTC_2036 5160441 105 µM -0.51820029334976 0.323594456382099 no 2274 0.302159265066914 3327 134534 YIL048W NEO1 SGTC_733 4069-0007 56.1 µM -0.518931535961392 0.323324357612502 no 2275 0.301904242652406 3423 5717425 YNL287W SEC21 SGTC_1303 1160-0052 261 µM -0.519172712734536 0.323235294659109 no 2276 0.301820152953412 3395 3562476 SGTC_2928 9011484 9.79 µM -0.52044319813442 0.322766290860037 no 2277 0.30137735411679 3390 2994751 SGTC_929 2805-0021 398 µM -0.521898638647974 0.322229356578441 no 2278 0.300870453109994 3390 3098024 SGTC_586 0957-0265 8.15 µM -0.523610440273986 0.321598321222963 no 2279 0.300274759235844 3355 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1638 st008370 60.6 µM -0.524990111147026 0.321090096177202 no 2280 0.299795032677415 3401 24207134 SGTC_1992 st073643 23.3 µM -0.525252495584324 0.320993480320763 no 2281 0.299703838046908 3364 3161292 SGTC_2936 9038235 15.59 µM -0.525719129617945 0.320821685109032 no 2282 0.299541685249085 3356 4749415 SGTC_2228 7354201 200 µM -0.526416838066083 0.320564889490274 no 2283 0.299299309547123 3368 753451 SGTC_2895 9054447 58.44 µM -0.52659830255007 0.320498114505755 no 2284 0.299236285502828 3356 2697450 SGTC_272 doxorubicin 8.13 µM -0.527001646018438 0.320349713690565 no 2285 0.299096222711263 3386 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.527029246493502 0.320339559789742 no 2286 0.299086639413073 3372 6312947 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.527860803750022 0.320033702435935 no 2287 0.298797975675082 3341 688664 SGTC_258 haloperidol 50.781 µM -0.528072648305427 0.319955802844349 no 2288 0.298724456974022 3356 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2865 9030313 51.95 µM -0.528707272836722 0.319722485898629 no 2289 0.298504265607915 3262 42562754 SGTC_3031 9088762 49.47 µM -0.53021141611377 0.319169779141094 no 2290 0.297982678359011 3310 205253 SGTC_1928 4'-methoxychalcone 40.3 µM -0.531233519062564 0.318794430223834 no 2291 0.297628484012089 3485 641818 SGTC_205 1486-1330 71.903 µM -0.534438929049659 0.317618507519488 no 2292 0.296518945756657 3395 4118834 SGTC_2448 5185112 27.17 µM -0.536203945045517 0.316971785150626 no 2293 0.295908803653615 3408 5718189 SGTC_1999 st074831 12.5 µM -0.536283326961832 0.316942711810232 no 2294 0.295881375954041 3337 17112523 SGTC_917 harmaline 728.087 nM -0.537407261501812 0.316531196198376 no 2295 0.295493164263637 3362 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_837 0091-0265 12.5 µM -0.537955624314742 0.316330501873173 no 2296 0.295303842517891 3326 759367 SGTC_2417 cerulenin 830 nM -0.538645399518769 0.316078129089072 no 2297 0.295065777579843 3475 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2972 9093619 59.92 µM -0.539977769354674 0.315590888455962 no 2298 0.2946061817884 3282 25236256 SGTC_1800 st050079 29.0735 µM -0.54091715131615 0.315247553934139 no 2299 0.294282344276567 3398 3645560 SGTC_1985 st071382 65.5 µM -0.54126803049173 0.315119352075567 no 2300 0.294161426255724 3439 6123237 SGTC_1632 st005650 90 µM -0.541644837896115 0.314981701530241 no 2301 0.29403159856429 3396 2759605 SGTC_99 0109-0120 622.8 µM -0.542409477393021 0.314702452025005 no 2302 0.293768226109919 3502 759414 SGTC_2085 5307070 144.047 µM -0.542548756816252 0.314651598005245 no 2303 0.293720264455549 3332 2840351 SGTC_2081 5214970 32.255 µM -0.542705456894251 0.314594387519043 no 2304 0.293666308232978 3407 2063512 SGTC_293 4049-0273 38.5 µM -0.543550396073919 0.314285980801034 no 2305 0.293375451121246 3359 1380311 SGTC_954 1189-0853 2.85 µM -0.544362201843477 0.31398978999802 no 2306 0.293096125464012 3433 2828194 SGTC_1556 plumbagin 1.48 µM -0.544422223893291 0.313967895450472 no 2307 0.293075478010037 3409 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1626 st003712 1.76 µM -0.546239346613087 0.313305364697592 no 2308 0.292450711407931 3450 24207035 SGTC_2929 9013348 24.6 µM -0.546755138570609 0.313117414345474 no 2309 0.292273483708724 3389 2995952 SGTC_1014 4130-3005 69.3 µM -0.547198882699462 0.312955756474635 no 2310 0.292121051853389 3349 743608 SGTC_1496 4469-0713 57.4 µM -0.547942311551005 0.312685002777075 no 2311 0.291865757364141 3457 746691 SGTC_2525 harmine 47.85 µM -0.54865567543051 0.312425293608172 no 2312 0.291620884978722 3352 5280953 A monoamine oxidase inhibitor SGTC_1331 1472-0049 76.2 µM -0.549296210393053 0.312192178087821 no 2313 0.291401093808766 3334 24051409 SGTC_677 0929-0063 136 µM -0.550215145090412 0.311857873398856 no 2314 0.291085908467394 3408 1539583 SGTC_3032 9089427 49.47 µM -0.551864410087306 0.311258266256846 no 2315 0.290520626886167 3431 17173707 SGTC_296 1222-0039 74.9 µM -0.552821258783651 0.310910623418828 no 2316 0.290192904976031 3392 5984176 SGTC_1220 1838-0075 193 µM -0.553493481908935 0.31066649177734 no 2317 0.289962771324762 3417 5529645 SGTC_261 5-fluorouridine 15.376 µM -0.553587790993131 0.310632248159873 no 2318 0.289930491727518 3519 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2307 7538926 6.34 µM -0.555472761728332 0.309948159930088 no 2319 0.289285667976484 3375 96582 SGTC_1173 0443-0020 122 µM -0.556896337816609 0.309431955319839 no 2320 0.288799128453087 3392 5331295 SGTC_1990 st072050 59.8 µM -0.55796496648971 0.309044705473114 no 2321 0.288434153598531 3366 17233948 SGTC_3019 9081971 49.47 µM -0.558613429875417 0.308809818575112 no 2322 0.288212786238844 3520 16451803 SGTC_1945 st075991 56.6 µM -0.559146615443312 0.308616746258016 no 2323 0.288030831578007 3380 1084980 SGTC_2911 7942208 15.64 µM -0.559331655251419 0.308549753684556 no 2324 0.287967697654414 3438 1243384 SGTC_1165 k072-0275 30.3 µM -0.559449613304063 0.308507050991775 no 2325 0.287927454834499 3499 6153523 YGL055W OLE1 SGTC_756 0508-1999 28.3 µM -0.559722258714684 0.308408358926084 no 2326 0.287834448710214 3351 6753853 SGTC_2679 rapamycin 1 nM -0.560792667775087 0.308021026645084 no 2327 0.287469442862233 3457 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_559 1550-0661 158 µM -0.561396635315872 0.307802572600744 no 2328 0.287263588629865 3447 5830875 SGTC_3352 9151559 45.5865 µM -0.562496850947518 0.307404801538771 no 2329 0.286888774282543 3386 17159339 SGTC_2728 chlorpromazine 9.18 µM -0.564497349581088 0.306682123215705 no 2330 0.286207851707097 3431 2726 A thorazine and dopamine antagonist. SGTC_618 k072-0232 33.2 µM -0.564779397385279 0.306580294034513 no 2331 0.286111911054987 3421 5872756 YGL099W LSG1 SGTC_785 1270-0111 65.3 µM -0.565769527190473 0.306222940578959 no 2332 0.285775232079607 3460 6741994 SGTC_1574 spiramycin 23.7 µM -0.566832539292385 0.305839487869541 no 2333 0.285413980443786 3436 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2775 cyproheptadine 69.59 µM -0.568429759880741 0.305263734032777 no 2334 0.284871593806991 3512 2913 A selective serotonin reuptake inhibitor. SGTC_88 0180-0332 8.668 µM -0.568905111528165 0.305092475819882 no 2335 0.284710268159933 3448 3101745 SGTC_2767 sibutramine 71.45 µM -0.569978589384286 0.304705883591933 no 2336 0.284346109950979 3539 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3164 9100705 49.47 µM -0.570408704105944 0.304551047259894 no 2337 0.284200263694092 3511 17174235 SGTC_3163 9099914 49.47 µM -0.571871947229727 0.304024558944799 no 2338 0.283704365158844 3483 16268368 SGTC_907 3448-6986 75.5 µM -0.572103233476242 0.303941377175648 no 2339 0.283626019334746 3538 590582 SGTC_3276 9139060 49.47 µM -0.572141403834579 0.303927650236313 no 2340 0.283613090517078 3492 4870619 SGTC_883 0850-0245 24.6 µM -0.572197045890448 0.30390764056769 no 2341 0.283594244304459 3521 6823229 YPR165W RHO1 SGTC_826 1683-5028 118 µM -0.572285261146749 0.303875918320587 no 2342 0.283564366633233 3470 722377 SGTC_615 k087-0205 167 µM -0.572885069237779 0.30366026622452 no 2343 0.283361257319219 3407 9642773 SGTC_1876 myriocin 605 nM -0.573287980431173 0.303515443854342 no 2344 0.283224861164519 3511 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1055 3448-0672 86 µM -0.573343538348779 0.303495476540779 no 2345 0.28320605580286 3468 748378 SGTC_2412 st077135 33.4 µM -0.573846500645862 0.303314740425294 no 2346 0.283035839321327 3570 13258915 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.574603317781901 0.303042873977963 no 2347 0.282779803851766 3402 6857784 SGTC_658 3253-0951 102 µM -0.574676579923191 0.303016562289017 no 2348 0.282755024767603 3449 1184878 SGTC_3016 9080866 49.47 µM -0.575153758417942 0.302845211315173 no 2349 0.282593656624421 3437 17066299 SGTC_3204 9114183 49.47 µM -0.575502305554857 0.302720078256301 no 2350 0.28247581591777 3430 17027248 SGTC_2969 9091408 28.7 µM -0.575917432262068 0.30257107247345 no 2351 0.282335496086293 3350 4286311 SGTC_718 1130-0073 349 µM -0.57592385057379 0.302568768939581 no 2352 0.282333326851912 3559 6740020 SGTC_1128 3448-9350 235 µM -0.576625512619951 0.302316989651059 no 2353 0.282096230389873 3402 619386 SGTC_2926 9010726 65.15 µM -0.576937985945489 0.302204894260824 no 2354 0.281990674351829 3475 2994293 SGTC_1310 1188-0297 994 nM -0.578201311617551 0.301751884319874 no 2355 0.281564106681806 3454 1588352 SGTC_2116 5511452 16.8835 µM -0.581749964523899 0.300481026072601 no 2356 0.280367555604148 3493 870744 SGTC_3263 9137018 49.47 µM -0.581920067458297 0.300420168867687 no 2357 0.280310261414095 3444 43844957 SGTC_2376 9072922 81.32 µM -0.582012445582272 0.300387121363028 no 2358 0.280279148925479 3526 17087968 SGTC_3177 9107506 49.47 µM -0.582092445940119 0.300358503228384 no 2359 0.280252206557926 3475 8897194 SGTC_2113 5491891 107.031 µM -0.583313633876905 0.299921806706032 no 2360 0.279841093033277 3461 789979 SGTC_984 1492-0255 2.91 µM -0.58475321975348 0.299407380511636 no 2361 0.279356831725283 3447 1585198 SGTC_966 1300-0360 30.2 µM -0.585176050037699 0.299256361044317 no 2362 0.279214673524277 3446 70588 SGTC_2502 avocadyne acetate 18.59 µM -0.585667181017316 0.299080990471832 no 2363 0.279049596351332 3473 3952079 SGTC_2948 9070189 9.45 µM -0.586521509817475 0.298776042278163 no 2364 0.278762555573831 3456 6473636 YDL196W YDL196W SGTC_1485 3909-9022 254 µM -0.586683994737443 0.298718060134417 no 2365 0.278707979516899 3518 714516 SGTC_2219 9098279 200 µM -0.586725434969188 0.298703273159419 no 2366 0.278694061245783 3491 902349 SGTC_3258 9138477 49.47 µM -0.586882379241401 0.298647274292788 no 2367 0.278641352423794 3527 4970355 SGTC_1105 epirubicin 18.1 µM -0.586891570915449 0.298643994784097 no 2368 0.278638265603946 3408 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_211 3455-0679 143.504 µM -0.587471266755698 0.298437197484362 no 2369 0.278443621262947 3519 748649 SGTC_2450 5739737 12.93 µM -0.58766944164363 0.298366516684115 no 2370 0.278377095324837 3493 2262825 SGTC_158 k038-0087 26.446 µM -0.588049372976138 0.298231032175312 no 2371 0.278249576671581 3449 X158 SGTC_3326 9140064 16.379 µM -0.588652897922281 0.298015871218454 no 2372 0.278047070512147 3453 1868434 SGTC_1168 k815-0004 80.5 µM -0.589339848246143 0.297771054645179 no 2373 0.277816659419918 3454 642433 SGTC_924 2046-0044 21.3 µM -0.589399681987203 0.297749735334432 no 2374 0.277796594904751 3508 3623589 SGTC_3057 9095946 49.47 µM -0.589500978233475 0.297713644140142 no 2375 0.277762628057241 3486 24540043 SGTC_2810 7959871 45.46 µM -0.589691847028841 0.297645644252957 no 2376 0.277698631086014 3460 2974535 SGTC_3087 9117406 49.47 µM -0.589798233464102 0.297607745557414 no 2377 0.277662963584914 3495 42546093 SGTC_889 0919-1524 82.7 µM -0.590533479233818 0.297345884656343 no 2378 0.277416523621669 3465 3905452 SGTC_635 k038-0028 24.7 µM -0.590828050436164 0.297241001414875 no 2379 0.277317819142307 3465 4035102 SGTC_2681 menadione 3.18 µM -0.591249720580809 0.297090893524252 no 2380 0.277176556433405 3528 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2889 9059656 51.95 µM -0.591527915366177 0.296991879570586 no 2381 0.277083378341112 3504 3949838 SGTC_2445 5742597 35.57 µM -0.591841104413716 0.296880428667869 no 2382 0.276978497676274 3411 1774255 SGTC_601 0986-0029 62.9 µM -0.593717155813169 0.296213221389637 no 2383 0.276350653285264 3516 24747981 SGTC_1788 fluconazole 20 µM -0.593832826482254 0.296172106278666 no 2384 0.276311965489704 3492 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1780 st038448 24.544 µM -0.594234146249427 0.296029477570037 no 2385 0.276177758661386 3542 728868 YDL195W SEC31 SGTC_1597 7-benzyloxygramine 47.5 µM -0.596967927908103 0.295058733847344 no 2386 0.275264396822415 3494 260807 SGTC_133 0724-0033 378.92 µM -0.598220941883661 0.294614289304008 no 2387 0.274846259885588 3411 280309 SGTC_579 4491-1009 110 µM -0.599356295737609 0.294211845756672 no 2388 0.274467657259806 3627 1271041 SGTC_413 propylparaben 100 µM -0.599768117018032 0.29406593219604 no 2389 0.274330392239432 3447 7175 A pharmaceutical preservative. SGTC_453 enantio-paf c16 10 µM -0.600923713232713 0.293656668364119 no 2390 0.273945399099697 3526 13871343 A lipid and platelet activating factor SGTC_1062 mesoridazine 14.2 µM -0.601252265014642 0.293540357224144 no 2391 0.273835989073214 3522 4078 A neuroleptic. SGTC_3010 9080089 71.4286 µM -0.601612842187791 0.293412733283878 no 2392 0.273715939242634 3525 17027233 SGTC_1550 gossypolone 36.6 µM -0.602884192976373 0.292962952200315 no 2393 0.273292866127687 3531 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1326 1431-2094 10.8 µM -0.603356134628609 0.292796069180303 no 2394 0.27313589845861 3482 616278 SGTC_1097 itavastatin 7.23 µM -0.604449163967124 0.292409733280619 no 2395 0.272772528836017 3533 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2224 6650123 117.647 µM -0.605185230868841 0.292149700893961 no 2396 0.272527963977193 3494 2908370 SGTC_1455 4262-0120 131 µM -0.605921548289141 0.291889687718278 no 2397 0.272283424855751 3604 1529587 SGTC_1190 1486-1332 13 µM -0.606034863604774 0.291849682652185 no 2398 0.272245801274679 3505 4150046 SGTC_329 k048-0121 21.3 µM -0.607438243846662 0.291354442307416 no 2399 0.271780057400825 3523 6832902 SGTC_2519 cryptotanshinone 88.04 µM -0.607650493485917 0.291279575459469 no 2400 0.271709652032756 3542 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2044 5102272 200 µM -0.608417208471199 0.291009206796874 no 2401 0.271455400514878 3523 592666 SGTC_712 r015-0009 80.6 µM -0.608987885763095 0.290808043549516 no 2402 0.271266234323214 3510 6813872 YLR060W FRS1 SGTC_845 0330-0138 4.51 µM -0.609731755256637 0.29054592784611 no 2403 0.271019757648175 3511 9039800 SGTC_804 1595-0054 20.9 µM -0.610220319702776 0.290373833608831 no 2404 0.270857935567093 3480 761523 Stimulates phospholipase C. SGTC_3255 9139072 49.47 µM -0.610313456561181 0.290341032061265 no 2405 0.270827092295176 3542 17646060 SGTC_1527 coumarin 137 µM -0.610510208812124 0.29027174427251 no 2406 0.270761941436016 3566 323 A hepatotoxic, DNA x-linker. SGTC_425 3825-7017 13.1 µM -0.611191310388751 0.290031949046852 no 2407 0.270536467722473 3582 3397440 SGTC_2551 apiole 73.87 µM -0.611284314602032 0.289999212288953 no 2408 0.270505686635837 3436 10659 A possible DNA adduct former. SGTC_2621 lithochol-11-enic acid 100 µM -0.611627320509298 0.289878491862837 no 2409 0.27039217900977 3550 6708711 SGTC_583 1488-1091 88.9 µM -0.612116979611345 0.289706197911912 no 2410 0.270230182120111 3593 4303273 SGTC_814 3342-0569 96 µM -0.612603033566869 0.289535220030929 no 2411 0.27006942595587 3586 4346283 SGTC_1564 D-Arginine 115 µM -0.613453921107009 0.289236019765052 no 2412 0.269788120964142 3484 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2037 5169046 200 µM -0.613967826238399 0.28905538411015 no 2413 0.269618294074699 3537 5718022 SGTC_347 4534-1311 26.2 µM -0.614022638350827 0.289036120997761 no 2414 0.269600183833446 3544 2862016 SGTC_709 3807-1509 243 µM -0.61462333941003 0.288825050817583 no 2415 0.269401748653931 3577 1886677 YPL242C IQG1 SGTC_716 1683-5115 658 µM -0.61498489426353 0.288698045163056 no 2416 0.269282348178708 3583 723597 SGTC_2008 4012253 172 µM -0.615426422739241 0.288542982349533 no 2417 0.26913657308554 3534 603940 SGTC_2907 7721985 69.9 µM -0.617555495786401 0.28779581287911 no 2418 0.268434194346295 3505 3267881 SGTC_1794 st048918 76.9 µM -0.618649651310977 0.287412189619 no 2419 0.268073592592416 3503 672303 SGTC_998 3996-0085 177 µM -0.620149501859329 0.286886718473964 no 2420 0.267579682135733 3542 715391 SGTC_2674 ligustilide 100 µM -0.620941800463868 0.286609321321684 no 2421 0.267318958404728 3528 5319022 A signalling regulator. SGTC_2636 apigenin dimethyl ether 100 µM -0.622082692474605 0.286210099346809 no 2422 0.266943747455819 3569 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1006 4099-6547 255 µM -0.622202025801438 0.286168357381266 no 2423 0.266904517071678 3559 3146833 SGTC_13 0199-0087 65 µM -0.623793632120774 0.285611901259833 no 2424 0.266381561085675 3567 4589825 SGTC_1356 1502-0781 85.8 µM -0.625172350274267 0.285130291531959 no 2425 0.265928973462155 3537 567702 SGTC_2842 9000675 19.48 µM -0.626043037392062 0.284826345248871 no 2426 0.265643356492924 3510 2989072 SGTC_2685 mycophenolic acid 18.85 µM -0.626396011819436 0.284703170224376 no 2427 0.265527612403572 3511 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.626911349070928 0.284523382251081 no 2428 0.265358673761206 3519 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1070 indatraline 8.81 µM -0.627435349529251 0.284340627527059 no 2429 0.265186951087429 3542 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3290 9121031 71.43 µM -0.6275471897426 0.284301628477308 no 2430 0.265150306709932 3506 17014854 SGTC_331 k048-0133 24.5 µM -0.627640788324047 0.28426899230982 no 2431 0.265119641168756 3551 6813582 SGTC_1000 4048-0884 8.67 µM -0.630932637855919 0.28312232332319 no 2432 0.264042285175611 3568 13040088 SGTC_1659 st012954 42.1 µM -0.632928576841131 0.282428148918403 no 2433 0.263390142667535 3573 24207262 SGTC_426 0988-0037 14.6 µM -0.635741186071103 0.281451333747025 no 2434 0.262472563573747 3600 5383008 SGTC_1775 st081588 35.1725 µM -0.635906982378147 0.281393803842282 no 2435 0.262418525692675 3609 1426443 YGL099W LSG1 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.635995238465678 0.281363182047174 no 2436 0.262389762767626 3524 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_547 1120-0019 610 nM -0.636857247073835 0.281064179618271 no 2437 0.262108916473409 3543 3676939 SGTC_1167 k781-0610 148 µM -0.637955131405029 0.280683582069052 no 2438 0.261751443992226 3593 4525169 SGTC_351 caspofungin 25 nM -0.637964872398344 0.280680206328316 no 2439 0.261748273432695 3608 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3114 9122766 49.47 µM -0.638358191572092 0.280543917997205 no 2440 0.261620269905248 3524 17176985 SGTC_1360 1598-0022 39.8 µM -0.638725986748413 0.280416502924037 no 2441 0.261500602094449 3579 761525 SGTC_2141 5621638 7.665 µM -0.640357869175691 0.279851508997446 no 2442 0.260969983251699 3591 2856238 SGTC_493 zm226600 134 µM -0.64071448998245 0.279728112512888 no 2443 0.260854099074911 3612 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1046 2001-0062 216 µM -0.642029751206228 0.279273239542172 no 2444 0.260426932987978 3530 739778 SGTC_1516 st013856 110 µM -0.645265744723761 0.278155628600577 no 2445 0.259377493715343 3572 5281404 A mutagen and neurotoxin. SGTC_2244 6635614 200 µM -0.645379322732289 0.278116441966513 no 2446 0.259340699862796 3479 836499 SGTC_2736 butenafine 14.65 µM -0.645608612863519 0.278037340593557 no 2447 0.259266429024814 3578 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_602 3130-1533 38.1 µM -0.646337834525994 0.277785843949178 no 2448 0.259030295246765 3608 720941 SGTC_339 3091-4833 71.4 µM -0.646698826549501 0.277661384813329 no 2449 0.258913441356842 3571 3240077 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.647813715833038 0.27727717675312 no 2450 0.25855272155741 3548 689007 SGTC_2320 7373003 200 µM -0.650468453140365 0.276363361358376 no 2451 0.25769483642754 3588 5415828 SGTC_3035 9091303 49.47 µM -0.650528097101556 0.276342847655233 no 2452 0.257675579317028 3631 25237002 SGTC_1295 1013-0063 9.78 µM -0.651286449747733 0.276082088053875 no 2453 0.257430796875186 3595 6826038 SGTC_213 1246-0773 967 nM -0.651351158980514 0.27605984337545 no 2454 0.257409915507419 3549 6251622 SGTC_1227 3909-8010 46.6 µM -0.651369145616301 0.276053660381193 no 2455 0.257404111460211 3581 15982272 SGTC_9 0092-0002 10.449 µM -0.652011335709717 0.275832948950922 no 2456 0.257196929855198 3580 759368 SGTC_2427 5545055 42.75 µM -0.652350691894203 0.275716352172826 no 2457 0.257087482717259 3613 5372858 SGTC_1212 0520-0165 585 µM -0.656770118550635 0.274200131292874 no 2458 0.255664370306562 3744 5403258 SGTC_2446 5162541 200 µM -0.657076917741954 0.274095027411262 no 2459 0.255565729933209 3576 1549321 SGTC_3077 9117319 49.47 µM -0.657169181980189 0.274063423237176 no 2460 0.255536069535953 3611 17154678 SGTC_292 k038-0015 474 µM -0.657469068384547 0.27396071264596 no 2461 0.255439676785183 3601 46368540 SGTC_2455 5377712 9.75 µM -0.659420448452218 0.273292833306662 no 2462 0.254812907344233 3562 2243908 SGTC_2342 7990637 118.86 µM -0.659536904003368 0.273253000744857 no 2463 0.254775528119215 3642 2033102 YER133W GLC7 SGTC_3154 9100113 49.47 µM -0.66055906948212 0.272903501796113 no 2464 0.254447562611296 3584 25237525 SGTC_1146 3579-1023 7 µM -0.665002397813607 0.271386819574683 no 2465 0.253024479710882 3640 X1146 SGTC_2643 anethole 100 µM -0.665700071194068 0.271149058350113 no 2466 0.252801414003541 3609 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2713 st079149 53.4 µM -0.666435236626497 0.270898632589864 no 2467 0.252566473114504 3635 3103253 SGTC_412 gemfibrozil 100 µM -0.66799280673093 0.27036844560559 no 2468 0.25206909208274 3606 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_529 4076-0302 30.3 µM -0.668663856853085 0.270140184371787 no 2469 0.251854964095223 3602 5816522 SGTC_1094 duloxetine 25.4 µM -0.668796511902831 0.270095072471693 no 2470 0.251812646050483 3627 60834 A selective serotonin reuptake inhibitor. SGTC_2885 9057732 51.95 µM -0.668939061870339 0.270046599815823 no 2471 0.251767175630895 3646 6471414 SGTC_2414 st077232 92.9 µM -0.669326950486189 0.269914724305643 no 2472 0.251643469331954 3591 729801 SGTC_982 1491-0518 27.5 µM -0.670762902404654 0.269426805881899 no 2473 0.25118579192523 3601 3091256 SGTC_1640 st009078 66.4 µM -0.67118203053279 0.26928447481585 no 2474 0.251052287302339 3634 690618 SGTC_3301 9125354 19.7965 µM -0.671336602925158 0.269231993338148 no 2475 0.251003060931295 3609 41905162 SGTC_2146 5545642 200 µM -0.673811037140627 0.268392555550247 no 2476 0.250215728466898 3654 825326 SGTC_1981 st071826 47 µM -0.674350166624475 0.268209833711194 no 2477 0.250044358476936 3599 11838600 SGTC_1863 st057641 20.1 µM -0.674490759476595 0.268162194254192 no 2478 0.249999679274407 3651 3921635 SGTC_2149 5554786 194.827 µM -0.675982026739749 0.267657145189389 no 2479 0.249526028222706 3672 745063 YPR165W RHO1 SGTC_1984 st072354 53.1 µM -0.676805601114881 0.267378430023252 no 2480 0.249264651952583 3579 5762938 SGTC_2626 ethyl orsellinate 100 µM -0.677081025299545 0.26728525327291 no 2481 0.249177273585188 3632 75653 A natural product. SGTC_1587 estradiol valerate 56.1 µM -0.677189827452444 0.267248449723961 no 2482 0.249142760573766 3636 13791 A steroid. SGTC_1443 4112-3303 14 µM -0.67801629996129 0.26696896964516 no 2483 0.248880679171808 3647 704433 SGTC_2833 9001315 45.46 µM -0.678733645219842 0.266726511781732 no 2484 0.248653321957859 3630 2989378 SGTC_1911 st060208 74.3 µM -0.678917689326614 0.26666432405929 no 2485 0.248595008391678 3648 688783 SGTC_2160 5660466 132.927 µM -0.679056106409636 0.266617558344403 no 2486 0.248551156347711 3595 2859134 SGTC_1690 st023502 41.2 µM -0.679621734949843 0.266426497704233 no 2487 0.248372001885987 3621 24207482 SGTC_811 0416-0114 265 µM -0.683546134076038 0.265102806188548 no 2488 0.247130904416835 3665 6612453 SGTC_1655 st012546 55.1 µM -0.684080007515882 0.264922990276118 no 2489 0.246962322782471 3612 720985 YLR208W SEC13 SGTC_2419 paclitaxel 166.5 µM -0.684571798592595 0.264757403147742 no 2490 0.246807083998054 3612 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1342 1486-1464 234 µM -0.684991726282033 0.264616054242336 no 2491 0.246674570970699 3676 3253938 SGTC_612 0302-0167 22.4 µM -0.685341728552023 0.264498271778085 no 2492 0.246564152836207 3672 235821 SGTC_876 0720-0963 56.8 µM -0.686913420855684 0.263969696300164 no 2493 0.246068644535315 3668 765861 SGTC_85 0868-0259 160.055 µM -0.687823814560502 0.263663768427975 no 2494 0.245781868717228 3609 83173 SGTC_1224 0823-0416 294 µM -0.688049806920677 0.263587854192225 no 2495 0.245710708484588 3691 3598164 SGTC_1090 efavirenz 20.7 µM -0.689871429945387 0.262976351116286 no 2496 0.245137521962752 3702 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_121 0557-0495 61.343 µM -0.690126116303109 0.262890912929419 no 2497 0.245057440441592 3775 3104427 SGTC_1693 xanthone 101.9 µM -0.69125503965676 0.262512370379288 no 2498 0.244702640397429 3714 7020 An insecticide. SGTC_3268 9137683 49.47 µM -0.691543614772858 0.262415652218847 no 2499 0.244611990902097 3674 1953228 SGTC_3264 9137442 49.47 µM -0.693348841887847 0.261811030873674 no 2500 0.244045329361754 3699 17015726 SGTC_20 0481-0013 4.944 µM -0.693438067776041 0.261781165156503 no 2501 0.244017339693563 3649 182045 SGTC_2823 7987624 58.44 µM -0.69546553303146 0.261103002716511 no 2502 0.243381802016747 3694 2239440 SGTC_286 k060-0067 22.9 µM -0.695957949818683 0.260938431698326 no 2503 0.243227582112366 3640 5985051 SGTC_15 0266-0086 27.098 µM -0.696397500140208 0.260791574298423 no 2504 0.243089964081105 3749 1712902 YIL048W NEO1 SGTC_3311 9131146 2.8755 µM -0.699622438783951 0.259715397619841 no 2505 0.242081562775841 3683 4900406 YPR165W RHO1 SGTC_1345 1488-0192 31.4 µM -0.700197727381623 0.25952366238648 no 2506 0.241901915343403 3689 658348 SGTC_2925 9010536 32.5 µM -0.701083700774485 0.25922852351155 no 2507 0.241625390777058 3671 2994177 SGTC_1250 0485-0349 40.2 µM -0.703050434195875 0.258573978203144 no 2508 0.241012159847589 3678 6842794 YDL195W SEC31 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.703648964521091 0.258374952305286 no 2509 0.240825705159199 3737 5024745 SGTC_3273 9137859 49.47 µM -0.705800123161175 0.257660295550392 no 2510 0.240156222738971 3742 2377234 SGTC_1957 st077035 62.4 µM -0.706333647394134 0.257483207392706 no 2511 0.2399903367515 3740 705593 SGTC_1546 5-methoxyflavanone 78.7 µM -0.707185626533113 0.257200548362062 no 2512 0.239725564798389 3708 147795 SGTC_1320 1313-0481 95.3 µM -0.707364291953859 0.257141293442443 no 2513 0.239670060668461 3707 6813365 YLR208W SEC13 SGTC_555 4296-0685 37 µM -0.708347453721821 0.256815351961584 no 2514 0.23936475753888 3663 2908540 YHR072W ERG7 SGTC_1277 0873-0036 22 µM -0.709553757215373 0.256415727678002 no 2515 0.238990452171422 3720 5965735 SGTC_3120 9124077 49.47 µM -0.709609811198578 0.256397165992982 no 2516 0.238973066897445 3740 18774327 YGL155W CDC43 SGTC_1114 scopoletin 1.73284 µM -0.709838654254587 0.256321394294889 no 2517 0.238902097863087 3694 5280460 A coumarin with genotoxic properties. SGTC_930 2810-3379 265 µM -0.710258807040489 0.256182308863426 no 2518 0.238771829678442 3717 1015764 SGTC_914 3820-6779 408 µM -0.711414426375131 0.255799961062622 no 2519 0.238413730926723 3668 2893481 SGTC_2200 6600604 21.907 µM -0.711741965154638 0.255691645902992 no 2520 0.238312288018566 3655 2904777 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.712319268773897 0.25550079329199 no 2521 0.238133547347292 3779 5282309 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.712394735113011 0.255475850140245 no 2522 0.238110187422584 3727 23665772 A membrane-active detergent. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.712656411530848 0.255389370645802 no 2523 0.238029197574614 3651 279621 SGTC_1667 st014849 34.6 µM -0.713205737690273 0.255207877706589 no 2524 0.237859228167202 3746 5348460 SGTC_391 gliotoxin 8.33 µM -0.714006541842479 0.254943419332675 no 2525 0.237611567135052 3751 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2875 9039966 71.43 µM -0.714213532128324 0.254875085982158 no 2526 0.237547575219407 3742 6463691 SGTC_340 k038-0059 454 µM -0.716001981916687 0.254285067569656 no 2527 0.236995062567128 3697 23733424 SGTC_3066 9117245 49.47 µM -0.71649571053129 0.254122310281346 no 2528 0.236842657596243 3767 17176980 SGTC_877 0771-0151 33.1 µM -0.716967935478183 0.253966692799411 no 2529 0.236696940846996 3736 6166523 SGTC_3167 9103034 49.47 µM -0.717164133956513 0.253902052063529 no 2530 0.236636413431667 3712 5127859 SGTC_357 1325-0123 420 µM -0.717914025498147 0.253655067862262 no 2531 0.236405149672232 3674 1098503 SGTC_468 gf-109203x 121 µM -0.719606081159921 0.253098236503337 no 2532 0.23588378338635 3646 2396 A protein kinase C inhibitor. SGTC_1841 st054148 70 µM -0.719758486214213 0.253048113761455 no 2533 0.235836854566664 3708 675442 SGTC_3308 9128332 17.569 µM -0.720758076992886 0.252719499363369 no 2534 0.235529186522042 3692 17332805 YDL196W YDL196W SGTC_584 0986-0246 15.4 µM -0.721852950444874 0.252359818930352 no 2535 0.2351924453205 3801 53315 YDR232W HEM1 SGTC_1622 st003707 19.4 µM -0.722704934292004 0.252080117753462 no 2536 0.234930591716322 3751 10140899 SGTC_111 0083-0039 52.457 µM -0.723319876116891 0.251878337714492 no 2537 0.234741692115773 3622 759313 SGTC_384 k007-0144 5.16 µM -0.724221928661864 0.251582502746407 no 2538 0.234464749017609 3717 6824886 SGTC_1526 st051518 75 µM -0.72500640005761 0.251325378714351 no 2539 0.234224052056192 3712 673993 SGTC_3353 9151644 39.2805 µM -0.725361413337511 0.251209062666632 no 2540 0.234115169393647 3741 4909158 SGTC_1381 2324-0066 62.1 µM -0.725605040268154 0.251129257559311 no 2541 0.234040465172996 3743 10885928 SGTC_3109 9122853 49.47 µM -0.725833713839504 0.251054362941201 no 2542 0.233970358169753 3768 1234709 SGTC_2610 ononetin 44.17 µM -0.725967277725589 0.251010623885944 no 2543 0.233929415384422 3734 259632 SGTC_1266 0828-0227 32.9 µM -0.727644844933677 0.250461603324861 no 2544 0.233415510695288 3733 3913820 SGTC_1393 3470-5649 58.2 µM -0.727798443137253 0.250411366773575 no 2545 0.233368488854287 3675 4108395 SGTC_1925 st057770 10.1 µM -0.728311498745079 0.250243603112512 no 2546 0.233211462496083 3699 5989122 SGTC_36 0335-0881 14.2 µM -0.728566240903364 0.250160327316875 no 2547 0.233133517627666 3665 23828853 SGTC_1021 4476-0760 85.3 µM -0.728889374712488 0.250054715284983 no 2548 0.233034667398989 3727 746768 SGTC_1065 prochlorperazine maleate 2.48 µM -0.728912069769839 0.250047298593405 no 2549 0.233027725603214 3760 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3143 9086658 49.47 µM -0.729203516778142 0.249952064767977 no 2550 0.232938590161341 3794 25236626 SGTC_1573 oleylamine 1.06 µM -0.729994083717373 0.249693834440018 no 2551 0.232696900482938 3737 5356789 An amine of the fatty acid oleic acid. SGTC_2112 5488546 200 µM -0.730276637760437 0.249601575531413 no 2552 0.232610552756217 3712 600757 SGTC_616 4092-0450 108 µM -0.731101272259614 0.249332421315024 no 2553 0.232358648636961 3765 787165 SGTC_1375 2910-0797 186 µM -0.731115237469125 0.249327864509456 no 2554 0.232354383940415 3743 742508 SGTC_2614 arthonioic acid 13.39 µM -0.731307366169944 0.249265177991022 no 2555 0.232295716086324 3682 6710684 SGTC_2367 9070478 135.38 µM -0.732561304904675 0.248856256829445 no 2556 0.231913019541209 3704 572802 SGTC_2682 pyrogallin 40.03 µM -0.732572145822549 0.2488527230623 no 2557 0.231909712472765 3761 822798 An ATP competetive kinase inhibitor. SGTC_1221 2958-7315 257 µM -0.73486064288289 0.248107349936069 no 2558 0.231212184883135 3746 4562705 SGTC_16 erodoxin 22.806 µM -0.735343280814253 0.247950304933285 no 2559 0.23106522777494 3751 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1093 fluphenazine 7.97 µM -0.735687017187117 0.24783848930216 no 2560 0.230960596217453 3756 6602611 An atypical antipsychotic. SGTC_2908 7930301 100 µM -0.735842194817091 0.247788019656924 no 2561 0.230913369624252 3740 2223178 SGTC_2719 novobiocin 32.65 µM -0.736069511924779 0.247714097427637 no 2562 0.23084419791525 3718 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1394 3474-0001 65.7 µM -0.737093625152549 0.247381207729467 no 2563 0.23053270779634 3712 5017666 YIL048W NEO1 SGTC_1307 1187-1599 12.2 µM -0.737738877705086 0.247171590170952 no 2564 0.23033657109157 3739 1538471 SGTC_1821 st053465 65.6 µM -0.73882644448388 0.246818496947562 no 2565 0.230006195895169 3716 675086 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.739064570494481 0.246741222175612 no 2566 0.229933894659197 3797 688801 SGTC_444 curcumin 90.4 µM -0.740452048598808 0.246291226491599 no 2567 0.229512873405168 3689 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3146 9095609 49.47 µM -0.740841972464326 0.246164843156702 no 2568 0.229394631334403 3804 17173999 SGTC_2437 5741531 144.16 µM -0.74174742661711 0.245871498745892 no 2569 0.229120189544525 3775 2262990 SGTC_1732 st034308 51.822 µM -0.742878537585802 0.245505310934539 no 2570 0.228777610386945 3650 830119 SGTC_3356 9151811 4.48 µM -0.743433530107445 0.245325743912291 no 2571 0.228609625224812 3722 1859254 YPR165W RHO1 SGTC_2695 st077686 51.995 µM -0.743702143071549 0.245238859938291 no 2572 0.228528346324831 3784 2876092 SGTC_93 0109-0045 59.227 µM -0.744084517859276 0.245115207774489 no 2573 0.228412672535589 3828 88733 SGTC_2799 7812892 81.82 µM -0.744335105495575 0.245034191064015 no 2574 0.228336884074811 3732 20205235 SGTC_87 0100-0052 35.5 µM -0.745051365848605 0.24480269860718 no 2575 0.228120334138823 3815 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2128 5255449 168.493 µM -0.74633035947794 0.244389625982154 no 2576 0.227733938109657 3755 736008 SGTC_1883 5-benzylidenerhodanine 20 µM -0.746530292218655 0.244325088285575 no 2577 0.227673569856067 3756 1273210 SGTC_1975 st070967 30.8 µM -0.748304376500475 0.243752821732537 no 2578 0.227138292655675 3725 261391 SGTC_950 1165-0508 94.1 µM -0.749755825328236 0.24328516641338 no 2579 0.226700889243024 3772 6148369 SGTC_2046 4110841 106 µM -0.750165413832859 0.243153285206466 no 2580 0.226577543169964 3756 44119630 YMR134W ERG29 SGTC_2721 ifenprodil 61.44 µM -0.75032339030864 0.243102429539385 no 2581 0.226529979260486 3737 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3298 9116858 71.43 µM -0.752364949707037 0.24244573005623 no 2582 0.225915809381306 3783 2506942 SGTC_561 1550-0330 72.9 µM -0.753306917412393 0.242143055727738 no 2583 0.225632751481329 3718 6812934 SGTC_2760 etidronate 98.04 µM -0.756023856060903 0.241271194133251 no 2584 0.224817446347919 3770 3305 A chelator and antioxidant. SGTC_2588 indole-3-carbinol 100 µM -0.756185493222959 0.241219378826345 no 2585 0.22476899460023 3781 3712 Induces cell cycle arrest. SGTC_1441 4106-0040 13 µM -0.756663162951567 0.241066289716016 no 2586 0.224625844729285 3750 2904180 SGTC_216 k038-0035 28.382 µM -0.756746789100233 0.241039493677163 no 2587 0.224600788649337 3681 4444231 YPR107C YTH1 SGTC_1466 k213-0079 57.5 µM -0.756851129364646 0.241006062556766 no 2588 0.224569528426109 3721 3657981 SGTC_415 dibenzyl ketone 100 µM -0.757000576374761 0.240958183411646 no 2589 0.224524758573698 3794 7593 SGTC_2074 5212007 75.395 µM -0.757191909273651 0.240896892610571 no 2590 0.224467448355107 3652 758611 SGTC_3161 9100388 49.47 µM -0.757737274326082 0.240722239138552 no 2591 0.224304139936934 3783 25236368 SGTC_588 3970-1144 52.9 µM -0.758001825894104 0.240637541175973 no 2592 0.224224944828515 3711 1888707 SGTC_1335 1486-0900 202 µM -0.759920850086967 0.24002363859125 no 2593 0.223650948874007 3772 X1335 SGTC_515 4092-1064 102 µM -0.760563221965118 0.239818332497115 no 2594 0.223458996964696 3786 717353 SGTC_260 nsc-65238 3.989 µM -0.761530472372006 0.239509373998786 no 2595 0.223170142576853 3697 3246252 SGTC_2363 9053361 176 µM -0.76177856762635 0.239430162607546 no 2596 0.223096087031514 3808 6469797 YMR079W SEC14 SGTC_834 0312-0008 75.7 µM -0.762018067050349 0.239353709250459 no 2597 0.22302461058653 3764 6385573 YIL048W NEO1 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.762876546761117 0.239079773694322 no 2598 0.222768512235927 3787 165521 SGTC_2892 9047358 58.44 µM -0.76307823875461 0.239015439898528 no 2599 0.222708368580107 3770 6466771 SGTC_1855 st056195 39.6 µM -0.764527261829892 0.238553522648442 no 2600 0.222276548518751 3713 4028379 SGTC_3278 9139605 49.47 µM -0.76643133669869 0.237947288358899 no 2601 0.221709846479365 3786 7958859 SGTC_2452 5863136 48.41 µM -0.769087686705513 0.237102951812067 no 2602 0.220920628706673 3758 2184096 SGTC_1947 st076332 61.6 µM -0.769612224626134 0.236936419182769 no 2603 0.220764975654047 3741 24208416 SGTC_613 3914-0030 117 µM -0.769768187787747 0.236886915709348 no 2604 0.220718706764859 3541 1145395 SGTC_943 3253-1379 105 µM -0.769785616620832 0.236881384065383 no 2605 0.220713536576423 3765 668464 SGTC_713 1488-1073 324 µM -0.774340733541275 0.235438097242337 no 2606 0.219364660724331 3755 3312542 SGTC_1868 st057644 42.7 µM -0.774389008267856 0.235422827448755 no 2607 0.219350390870981 3797 688665 SGTC_154 3389-1638 511.116 µM -0.774621711026836 0.23534922883551 no 2608 0.219281612170123 3739 5238686 SGTC_2565 isoliquiritigenin 100 µM -0.776045804361686 0.234899097168946 no 2609 0.218860970702861 3853 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2459 5811157 9.22 µM -0.776757649691991 0.234674273450272 no 2610 0.218650883584792 3779 2870684 YBR192W RIM2 SGTC_1361 1608-0041 5.61 µM -0.776950531907466 0.234613375519213 no 2611 0.218593978195768 3754 X1361 SGTC_1107 amlodipine 47 µM -0.777356436408628 0.234485249466582 no 2612 0.218474253415823 3626 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_336 4111-0029 111 µM -0.77757298565805 0.234416910308809 no 2613 0.218410395932377 3773 3131175 SGTC_2272 7805186 180 µM -0.778342740725444 0.234174078301181 no 2614 0.218183492479667 3782 2956062 YPR165W RHO1 SGTC_2524 avocatin b 10.57 µM -0.779060128549374 0.233947891853345 no 2615 0.217972147855995 3776 6710748 SGTC_3253 9135987 49.47 µM -0.780669409607747 0.233440939410151 no 2616 0.217498478410453 3780 4182430 SGTC_280 3448-3607 3.04 µM -0.781263063097792 0.23325408187483 no 2617 0.217323894911895 3787 626179 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.781403988191529 0.23320973668597 no 2618 0.217282463102593 3835 6710655 SGTC_608 k048-0125 159 µM -0.781559968469515 0.233160659507978 no 2619 0.217236610406416 3817 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2703 st077852 53.4 µM -0.782355417979238 0.232910470796252 no 2620 0.217002863270471 3801 6281836 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.782575202863491 0.23284136927184 no 2621 0.216938303933486 3790 4330530 SGTC_802 4112-3352 742 µM -0.783643273625939 0.232505724428419 no 2622 0.216624728269556 3905 704594 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.784194373263148 0.232332644787826 no 2623 0.216463033127429 3812 91467 include heat shock SGTC_2992 9074591 71.4286 µM -0.78530884580689 0.23198285007424 no 2624 0.216136255330571 3784 17741321 SGTC_3332 9141069 11.198 µM -0.785520711165555 0.231916385991358 no 2625 0.216074165994568 3756 17332883 SGTC_288 1315-0019 35.1 µM -0.785764953096859 0.231839778245592 no 2626 0.216002601190357 3877 6811474 SGTC_2852 9023854 51.95 µM -0.786713329455395 0.231542448760576 no 2627 0.215724849674817 3888 19798528 SGTC_502 l-744,832 89.3 µM -0.787062310060056 0.231433091898803 no 2628 0.215622695663331 3775 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_138 0850-0259 40.9225 µM -0.787686915451694 0.231237436937225 no 2629 0.21543993048558 3822 6813004 SGTC_3350 9150499 3.57 µM -0.788356085967376 0.231027924569568 no 2630 0.215244224897948 3791 4910996 YPR165W RHO1 SGTC_3092 9117248 49.47 µM -0.789831530330259 0.230566348376149 no 2631 0.214813081217476 3874 17141857 SGTC_626 0214-0009 33 µM -0.790044308078101 0.230499825793721 no 2632 0.214750946263809 3863 3437874 SGTC_2283 7944793 200 µM -0.791139389200762 0.230157630663454 no 2633 0.214431327974901 3851 2970533 SGTC_519 k048-0011 62.8 µM -0.791355637285514 0.230090090253343 no 2634 0.214368244967207 3891 6836379 SGTC_1005 4092-0690 4.4 µM -0.792398994566006 0.229764376058811 no 2635 0.214064032745584 3851 1529343 SGTC_575 k072-0246 11.9 µM -0.792660697685611 0.229682718372074 no 2636 0.21398776726513 3847 6796779 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.793280763183044 0.229489307874235 no 2637 0.213807131025245 3847 5377381 SGTC_694 1315-0438 43.2 µM -0.793425113722483 0.229444295231177 no 2638 0.213765091860945 3785 6793154 SGTC_2998 9066762 71.4286 µM -0.798024598010312 0.22801263720057 no 2639 0.212428107894046 3838 4945196 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.799294831814559 0.227618145244095 no 2640 0.212059737464955 3855 368090 SGTC_477 mead ethanolamide 10 µM -0.799892122998513 0.227432779577294 no 2641 0.211886650987951 3687 16061185 SGTC_3009 9080819 71.4286 µM -0.800591164352585 0.227215944402002 no 2642 0.211684183763763 3861 17027216 SGTC_3045 9092950 49.47 µM -0.801772845109136 0.226849664715174 no 2643 0.211342184625428 3792 44120432 SGTC_2880 9042983 58.44 µM -0.80239824742278 0.226655946751905 no 2644 0.211161313277484 3865 6464714 SGTC_1437 4092-1038 11.6 µM -0.803434665979 0.226335122431293 no 2645 0.210861772552257 3845 3977136 SGTC_490 phenamil 164 µM -0.805740167356352 0.225622373081941 no 2646 0.210196341930744 3823 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_816 0325-0417 81.3 µM -0.805836956748471 0.225592478295106 no 2647 0.210168432873571 3873 68101 SGTC_299 1273-0059 1.44 µM -0.805973457767516 0.225550321814763 no 2648 0.210129076735663 3761 2848077 SGTC_2352 9027995 87.8 µM -0.806163911400822 0.225491510255136 no 2649 0.210074172149903 3812 2997347 SGTC_810 3825-7150 143 µM -0.80642421172776 0.225411144268644 no 2650 0.209999145567937 3852 22330411 YGL099W LSG1 SGTC_464 bw-b 70c 158 µM -0.806959441693306 0.225245946556034 no 2651 0.209844925266705 3912 5353454 SGTC_291 SEC14.278 35.5 µM -0.8069890645952 0.225236805506641 no 2652 0.209836391716143 3832 1068044 SGTC_1473 k844-0725 134 µM -0.807475141153588 0.225086841780564 no 2653 0.209696395447675 3901 54682906 SGTC_1939 st074455 53.6 µM -0.808438275393426 0.224789863990622 no 2654 0.209419162745996 3823 1644229 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.80907316374283 0.224594220796591 no 2655 0.209236531748552 3853 364106 SGTC_650 1328-0195 38 µM -0.809700749414752 0.224400922922213 no 2656 0.209056093604097 3773 2780821 SGTC_125 0133-0007 11.75 µM -0.809855199252459 0.224353366488377 no 2657 0.209011701542918 3920 26541 SGTC_2175 5807670 165.306 µM -0.810067396802958 0.224288038367206 no 2658 0.208950720655336 3824 241186 SGTC_729 4092-0585 94.1 µM -0.810912969378268 0.224027823763332 no 2659 0.208707825888821 3850 2169061 SGTC_506 n9-isopropylolomoucine 153 µM -0.811679516541034 0.223792076546431 no 2660 0.208487775427882 3822 6610355 SGTC_2191 5911152 200 µM -0.811720075605471 0.223779606766311 no 2661 0.208476136067624 3851 2875902 SGTC_1867 st057372 64 µM -0.812412028333354 0.223566928535637 no 2662 0.208277623290865 3832 688837 SGTC_3063 1327-0034 4 µM -0.814397350059121 0.222957359593605 no 2663 0.207708678116293 3741 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2364 9055074 200 µM -0.815068001651574 0.222751658273091 no 2664 0.207516693247649 3874 6470630 SGTC_368 fentichlor 4.58 µM -0.81614117872709 0.222422720011026 no 2665 0.207209697227317 3890 7329 A pesticide. SGTC_2100 5377183 190 µM -0.818136796684055 0.221811782643903 no 2666 0.20663953987281 3882 2844202 SGTC_1604 st002052 72.4 µM -0.819499409479745 0.221395184399499 no 2667 0.206250769368126 3898 6254834 YHR062C RPP1 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.821836144906917 0.220681805400542 no 2668 0.205585079625605 3927 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.823808139520998 0.22008080342177 no 2669 0.20502429098514 3884 6708784 An antioxidant flavonoid SGTC_1853 st056710 91.2 µM -0.824066723328776 0.220002064894033 no 2670 0.204950823357428 3963 269167 SGTC_1431 4049-0260 9.09 µM -0.824191512982151 0.219964072343977 no 2671 0.204915374301848 3842 3854841 SGTC_1104 tacrolimus 29.8 µM -0.825802892124257 0.219473821853785 no 2672 0.204457956618493 3900 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2955 9076254 12.21 µM -0.829025934996539 0.21849512002692 no 2673 0.203544865927969 3826 16459619 SGTC_3145 9085516 49.47 µM -0.830439197636008 0.218066765785134 no 2674 0.203145255711123 3939 25236195 SGTC_2850 9015429 58.44 µM -0.83047041009826 0.218057310879813 no 2675 0.20313643545135 3940 6457570 SGTC_2990 9074105 71.4286 µM -0.83092035823601 0.217921038471613 no 2676 0.203009311020125 3814 6502001 SGTC_2289 7946404 165.07 µM -0.831577997251454 0.217721952657627 no 2677 0.20282359290102 3909 1246120 YPR165W RHO1 SGTC_2944 9067346 25.62 µM -0.83173904673512 0.217673214451761 no 2678 0.202778127792431 3803 6473075 SGTC_1045 1348-1485 165 µM -0.835348949327922 0.216582407209161 no 2679 0.201760632214688 3901 6810614 SGTC_1608 st001473 40.5 µM -0.83545928128074 0.216549117990593 no 2680 0.201729582021719 3854 7292267 SGTC_244 nsc-207895 1.295 µM -0.835827463204497 0.21643805202583 no 2681 0.201625987057952 3720 42640 SGTC_1737 st035557 69.7 µM -0.836368358261034 0.216274945125109 no 2682 0.201473853792296 3782 5716916 SGTC_2979 9012552 45.46 µM -0.837652387014517 0.215888031362762 no 2683 0.201112980775671 3925 17100905 SGTC_1159 4092-0538 61.2 µM -0.83831906571593 0.215687300725897 no 2684 0.200925765409426 3921 717301 SGTC_1771 st048882 4.1505 µM -0.841280013840472 0.214797095790289 no 2685 0.20009554224787 3905 4580403 SGTC_2001 4023502 57.655 µM -0.841703252286443 0.214670024338826 no 2686 0.199977038675981 3917 108941 YCR052W RSC6 SGTC_2306 7482397 179.52 µM -0.842252480193675 0.214505191454581 no 2687 0.19982332193162 3867 891448 SGTC_3000 9075062 71.4286 µM -0.842362254040073 0.214472255232243 no 2688 0.199792607183811 3863 17057871 SGTC_1387 3342-1166 1.8 µM -0.843306287044152 0.214189131743376 no 2689 0.199528583772156 3881 3418228 SGTC_1759 st043059 70 µM -0.845895841492823 0.213413619735302 no 2690 0.19880542628704 3903 669426 SGTC_860 0443-0016 25.1 µM -0.846428817385226 0.213254209051717 no 2691 0.198656784051832 3927 5337942 SGTC_1282 0886-0010 32.4 µM -0.847381739393177 0.212969367496219 no 2692 0.198391189675836 3969 2836211 YNL267W PIK1 SGTC_1042 0350-0096 82 µM -0.847768128758455 0.212853933664433 no 2693 0.198283557954741 3896 3122515 SGTC_921 1561-0023 372 µM -0.848389243638386 0.212668452134356 no 2694 0.198110615520348 3864 24050882 SGTC_2302 7771753 200 µM -0.848433655059466 0.212655193311616 no 2695 0.198098253150846 3922 2203047 SGTC_2534 helenine 20.12 µM -0.854257650940069 0.210920652536375 no 2696 0.196481123154365 3901 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_410 α-linolenic acid 100 µM -0.854703777517222 0.210788127124346 no 2697 0.196357579380676 3983 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.855773757204241 0.210470480336446 no 2698 0.196061466799871 3900 66535 A nucleotide analog. SGTC_333 3486-0131 40.1 µM -0.857011706591252 0.210103318895394 no 2699 0.195719207456483 3980 6744690 SGTC_534 k292-0788 63.4 µM -0.857560367284779 0.209940712904241 no 2700 0.195567633753533 3901 4146317 SGTC_2776 terbinafine 19.92 µM -0.857571209253108 0.209937500426874 no 2701 0.195564639255889 3935 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1751 st044839 27.194 µM -0.85827161824391 0.20973003032598 no 2702 0.195371248782675 3861 5291326 SGTC_3004 9076122 71.4286 µM -0.859928142460491 0.209239826654876 no 2703 0.194914327112845 3948 44782551 SGTC_1937 st074714 47.2 µM -0.860786021668818 0.208986225745972 no 2704 0.194677952565677 3872 17250970 SGTC_560 2332-1943 155 µM -0.861771866203561 0.208695020198887 no 2705 0.194406534742579 3893 21177716 SGTC_632 0781-2353 4.65 µM -0.861812254539902 0.208683095115906 no 2706 0.194395420140706 3984 6811515 YHR007C ERG11 SGTC_1202 1988-0068 29.6 µM -0.86355048221255 0.208170245741869 no 2707 0.193917438101411 3882 2850480 SGTC_2516 gossypol 71.55 µM -0.865013074252185 0.207739297085347 no 2708 0.193515806417943 3958 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3280 9140961 49.47 µM -0.866310916395435 0.207357333182058 no 2709 0.193159840717682 3966 4901226 SGTC_3295 9122362 53.5725 µM -0.866392081247356 0.207333459609436 no 2710 0.193137592513325 3981 4730473 SGTC_1060 3448-7350 82 µM -0.86831594531356 0.206768056267976 no 2711 0.192610697710497 3876 570178 SGTC_1679 SEC14.276 6.7 µM -0.868729141113889 0.206646741572277 no 2712 0.192497649164796 3941 1005053 YMR079W SEC14 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.8687400612526 0.206643535980574 no 2713 0.192494662013361 3905 4620898 SGTC_3003 9075612 71.4286 µM -0.869088289871061 0.206541329391614 no 2714 0.192399420609954 3958 6501993 SGTC_2952 9073731 13.78 µM -0.86947382527298 0.206428208037265 no 2715 0.192294009323834 3997 16457353 SGTC_1172 0370-0043 85 µM -0.87056252722711 0.206108966265778 no 2716 0.191996532285751 3977 376585 SGTC_2537 larixol 68.93 µM -0.872576725906034 0.205519112022363 no 2717 0.191446915470146 3937 6708759 SGTC_1708 st033234 31.827 µM -0.872971361736917 0.205403661207019 no 2718 0.191339343771221 4026 674664 SGTC_491 tetrandrine 80.3 µM -0.873128347632981 0.205357745652854 no 2719 0.191296562115354 3936 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_610 4215-0184 155 µM -0.873505795844893 0.205247373785125 no 2720 0.191193724264545 3947 5605015 SGTC_176 1486-1328 72.834 µM -0.87426996881456 0.205024025374385 no 2721 0.190985624914683 4000 22310231 SGTC_2923 7992654 58.14 µM -0.875090802482154 0.204784277483993 no 2722 0.190762250564747 3948 2985126 SGTC_500 h-89 112 µM -0.875455126909662 0.204677919589848 no 2723 0.190663157957546 3972 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.875615440951901 0.204631129232475 no 2724 0.190619564150267 3968 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_295 k015-0027 31 µM -0.875762467552281 0.204588222634211 no 2725 0.190579588943958 3960 3887424 SGTC_1976 st070609 63.5 µM -0.876760801661797 0.204297021582546 no 2726 0.190308287041947 3841 682556 SGTC_793 0488-0545 106 µM -0.876794149780883 0.204287298632102 no 2727 0.19029922863322 3951 292548 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.877091682557572 0.204200562413957 no 2728 0.190218421000979 3994 1273210 SGTC_2031 5180455 200 µM -0.877520359787969 0.204075633770861 no 2729 0.190102032609974 3898 29949 SGTC_2404 5161160 200 µM -0.878253065862429 0.203862207990709 no 2730 0.18990319995264 3905 2831543 SGTC_2243 6634756 200 µM -0.879216517346274 0.203581772253015 no 2731 0.189641945153375 4018 885676 SGTC_1205 4161-2785 76 µM -0.879618693404233 0.203464777329928 no 2732 0.189532954323313 4040 3498106 SGTC_1656 st012921 11 µM -0.880319518102305 0.203260999968944 no 2733 0.18934312100211 3872 6732821 SGTC_247 mechlorethamine 29.705 µM -0.882657173410286 0.202582166015071 no 2734 0.188710763902854 3840 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_772 k072-0172 35.3 µM -0.883273436105531 0.202403434871878 no 2735 0.188544276287474 3991 5861980 SGTC_79 0052-0007 94.094 µM -0.883698824453873 0.202280116950488 no 2736 0.188429407545031 3922 2801472 SGTC_150 3970-0969 77.2 µM -0.884403049616412 0.202076064464209 no 2737 0.188239338657801 4036 6615640 SGTC_264 promethazine 12.5 mM -0.885554784667962 0.201742609514068 no 2738 0.187928742842476 3883 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1943 st076331 65.2 µM -0.886583638434418 0.201445010497043 no 2739 0.18765155296574 3976 24208415 SGTC_3175 9106517 49.47 µM -0.887484280225787 0.201184713251305 no 2740 0.187409112919503 3985 41468073 SGTC_2300 7976697 71.57 µM -0.887817117554575 0.201088569975918 no 2741 0.187319566830588 3856 2236109 SGTC_2165 5727197 32.143 µM -0.888281641003838 0.200954433970309 no 2742 0.187194636321595 4131 1361712 SGTC_290 2043-6722 48.1 µM -0.888606335110443 0.200860707032626 no 2743 0.187107342591978 3969 773758 YLR208W SEC13 SGTC_988 1497-1057 103 µM -0.889258972994889 0.200672394472335 no 2744 0.186931957643205 3872 3533044 SGTC_2900 5328528 85.29 µM -0.889699620260626 0.200545309782335 no 2745 0.186813598988658 3976 795359 SGTC_408 cantharidin 100 µM -0.891112321810033 0.200138206147648 no 2746 0.186434457598875 3917 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_458 nppb 133 µM -0.891377464952919 0.20006185422844 no 2747 0.186363351537954 3960 4549 A chloride channel blocker. SGTC_521 r062-0005 13.8 µM -0.893203263522046 0.199536563928395 no 2748 0.185874165367418 3866 2832033 SGTC_1184 1269-1718 139 µM -0.894635422505658 0.199125107000154 no 2749 0.185491004884392 4029 5403821 SGTC_2303 7774051 200 µM -0.896700155485859 0.198532813028394 no 2750 0.18493946882147 3954 2953184 SGTC_2795 7780010 54.55 µM -0.897423260484971 0.198325633019674 no 2751 0.184746552592638 3970 953673 SGTC_1902 st060212 70.5 µM -0.89811686383838 0.198127028311219 no 2752 0.18456162466277 3964 688944 SGTC_955 1216-0110 33 µM -0.898228635673246 0.198095035072195 no 2753 0.184531834926099 3929 3619719 SGTC_2849 9019321 12.99 µM -0.898342141578694 0.198062548670549 no 2754 0.184501586080766 3988 16489627 SGTC_2206 7254556 146.969 µM -0.900867551147889 0.197340586286056 no 2755 0.183829372908742 3978 4398905 SGTC_465 cgp-37157 41 µM -0.901364441845161 0.197198723135073 no 2756 0.18369729043584 3919 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1826 st055655 41.6 µM -0.902989524007684 0.196735190432068 no 2757 0.183265727459614 4009 676168 SGTC_1263 0774-1208 64.8 µM -0.903038675909442 0.196721180806164 no 2758 0.183252684352898 3992 906585 SGTC_21 0849-0113 22.993 µM -0.906574526606157 0.195714953215814 no 2759 0.182315918764395 3929 1560156 SGTC_3310 9130229 44.1445 µM -0.906896458668001 0.195623493663561 no 2760 0.182230777026325 4055 7761258 SGTC_2689 tacrolimus 100 µM -0.907143698456115 0.195553271493784 no 2761 0.182165406112116 4001 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_754 3474-0146 171 µM -0.909849921388405 0.194785638862838 no 2762 0.181450831529363 3945 24762078 SGTC_1058 3448-5425 97.3 µM -0.912881904108205 0.193927783509404 no 2763 0.180652327881598 3853 7279705 SGTC_972 1319-0219 195 µM -0.913375048009727 0.193788473640593 no 2764 0.180522662041656 3957 23903702 SGTC_523 1934-0222 13.7 µM -0.913597696626085 0.19372559688345 no 2765 0.180464138587035 3960 1361595 SGTC_678 1218-2179 85.9 µM -0.915939822537974 0.193064926109555 no 2766 0.179849229277353 3965 6820081 YOR116C RPO31 SGTC_1649 st011737 51.3 µM -0.918769174798056 0.192268654979759 no 2767 0.179108159448442 3977 1761035 SGTC_2225 6654152 15.4 µM -0.91941284678502 0.192087785747601 no 2768 0.17893983614078 3864 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1047 2043-3044 82 µM -0.920022725051572 0.191916508503168 no 2769 0.178780441931771 3986 669592 SGTC_1914 st062367 72.6 µM -0.920721818651898 0.191720291201899 no 2770 0.178597840913693 3991 978205 SGTC_386 1509-0011 3.07 µM -0.923499664843512 0.190941837001605 no 2771 0.177873437481608 4023 3107280 SGTC_1088 bifonazole 369 nM -0.923581172217931 0.190919024969985 no 2772 0.177852210108902 3951 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_905 2-aminofluorene 215 µM -0.925433545492773 0.190401039317239 no 2773 0.177370218133715 3994 1539 An established DNA mutagen. YPR165W RHO1 SGTC_131 0141-0277 33.849 µM -0.927742323084183 0.189756637293609 no 2774 0.176770624398656 3990 1547771 SGTC_35 0133-0054 64.071 µM -0.931696357632862 0.188656148282624 no 2775 0.175746734689523 4020 99677 SGTC_1433 4060-0023 7.6 µM -0.933249741243561 0.188224888360692 no 2776 0.175345518958583 4029 3840627 SGTC_203 k066-0004 30.888 µM -0.933681206439156 0.188105210366103 no 2777 0.175234181092307 4074 6795412 SGTC_1450 4112-4260 37.6 µM -0.933695090233667 0.188101360117892 no 2778 0.175230599179415 3991 1633175 SGTC_2896 9052656 71.43 µM -0.934661611428242 0.187833444422618 no 2779 0.174981358230757 3886 6469436 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.935415627336217 0.187624598037594 no 2780 0.17478707319838 4061 279621 SGTC_939 1165-0479 45.3 µM -0.935556877261014 0.187585490770884 no 2781 0.174750692984934 4007 1377347 SGTC_392 N-ethylmaleimide 8.33 µM -0.936262868265466 0.187390101547273 no 2782 0.174568930589402 3959 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_3307 9126885 69.2785 µM -0.938320208925169 0.186821432247708 no 2783 0.174039938637938 4001 24824909 SGTC_1033 k072-0102 21.3 µM -0.940350510446056 0.186261285135593 no 2784 0.173518899280466 4009 5965931 SGTC_2397 5161689 200 µM -0.94056676798061 0.186201682463885 no 2785 0.173463459342962 4064 2259942 SGTC_207 4185-0010 4.486 µM -0.941130013380188 0.186046502064742 no 2786 0.173319118274531 4065 3761753 SGTC_2587 piperic acid 92.2 µM -0.942708478053551 0.185612044756042 no 2787 0.172915017838852 4029 5370536 SGTC_1648 st011736 69.8 µM -0.943437141586732 0.185411699641959 no 2788 0.172728676456247 4024 2855514 SGTC_2005 4024620 188 µM -0.944438169511001 0.185136687261845 no 2789 0.17247289203409 4007 236743 SGTC_2377 9073351 62.6 µM -0.944627661525338 0.185084656659705 no 2790 0.172424499907085 3992 7337946 YHR072W ERG7 SGTC_443 clozapine 122 µM -0.944923307540796 0.185003496500515 no 2791 0.172349015662516 3919 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2429 5902844 64.44 µM -0.945613758303373 0.184814041459948 no 2792 0.172172812118234 4048 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_170 4197-0004 226 µM -0.947668959721871 0.184250822086673 no 2793 0.171649003883436 4058 218692 SGTC_72 0744-0168 198.391 µM -0.949439366300845 0.18376650688796 no 2794 0.17119859830672 3926 677577 SGTC_2654 protoveratrine a 100 µM -0.950047725157031 0.183600266529471 no 2795 0.171044001574984 4019 5702278 A heart drug and vasodilator. SGTC_2432 5630864 12.22 µM -0.953514248719666 0.182654792460246 no 2796 0.170164790137718 4084 5714970 SGTC_1241 0364-0022 50.8 µM -0.95437643909904 0.182420108009903 no 2797 0.169946564031789 4058 4563895 SGTC_2170 morpholine 200 µM -0.954440062142178 0.182402797562307 no 2798 0.169930467728592 4065 121171 Reacts with secondary amines. SGTC_2627 acetyl isogambogic acid 100 µM -0.954651360399344 0.182345315261791 no 2799 0.169877017367902 4063 6857789 A caspase activator and apoptosis inducer. SGTC_3322 9139058 2.11 µM -0.956305776643077 0.181895633551988 no 2800 0.169458886145611 4127 4908926 YPR165W RHO1 SGTC_1245 0418-0076 17.2 µM -0.959755553946414 0.180960193619642 no 2801 0.168589128150506 4104 6790114 SGTC_301 4119-0100 24.5 µM -0.963152826122458 0.180041942788919 no 2802 0.167735417398874 4072 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2133 5320837 200 µM -0.96326526473366 0.180011601785757 no 2803 0.167707210036283 4094 2841355 SGTC_1642 st009582 77.7 µM -0.964973838814651 0.179550946643987 no 2804 0.167278957682258 4016 6739311 SGTC_439 amiodarone 34.4 µM -0.967059293192325 0.178989684429064 no 2805 0.166757196754995 3908 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1427 4048-4900 550 nM -0.969311371461859 0.178384819690989 no 2806 0.166194928656957 4037 24132586 SGTC_2993 9054257 71.4286 µM -0.970870051110088 0.177966943449524 no 2807 0.165806496770776 3994 6470217 YGL055W OLE1 SGTC_3056 9094900 49.47 µM -0.972549494004819 0.177517382507601 no 2808 0.16538862737796 4038 25236784 SGTC_556 4058-0063 51.5 µM -0.973270828216019 0.177324512715584 no 2809 0.165209358472601 4091 6615692 SGTC_3080 9117754 49.47 µM -0.973961495856324 0.177139966576018 no 2810 0.165037828850607 4083 9550191 SGTC_829 1635-0120 117 µM -0.974737619103402 0.176932731551799 no 2811 0.164845213679446 4080 285054 SGTC_1520 flindersine 88 µM -0.976072737880851 0.176576596072811 no 2812 0.164514210039934 4176 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3121 9125696 49.47 µM -0.976129753947433 0.176561397455526 no 2813 0.164500084171692 4139 1235365 SGTC_166 k072-0058 166.424 µM -0.976769564073813 0.17639090175329 no 2814 0.16434162357636 3984 5846229 SGTC_2961 9083290 32.55 µM -0.977334840189242 0.176240354465456 no 2815 0.164201705053308 4000 17741490 SGTC_2781 5567276 71.43 µM -0.978895599387545 0.175825107287004 no 2816 0.163815783384528 4114 2853274 SGTC_2772 vinpocetine 57.06 µM -0.979707923201621 0.175609230198384 no 2817 0.163615156970433 4093 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1936 st074407 74.3 µM -0.981950163974121 0.175014221207069 no 2818 0.163062200301457 4114 809813 SGTC_965 1291-5240 308 µM -0.983542463903125 0.17459246046231 no 2819 0.162670263325722 4088 2834598 SGTC_2677 mitomycin C 100 µM -0.983982334281955 0.174476063581687 no 2820 0.162562099462692 4095 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_698 k064-0052 127 µM -0.984738057169587 0.174276202085117 no 2821 0.16237637694363 4144 5088751 SGTC_2253 7938677 135.83 µM -0.984813490274124 0.174256260732808 no 2822 0.162357846480465 4150 2301972 SGTC_1444 4112-3581 28 µM -0.985299329696333 0.17412785989052 no 2823 0.162238530942501 4092 2877249 SGTC_2851 9015922 71.43 µM -0.985773765775631 0.174002530851095 no 2824 0.162122071017742 4107 2996893 SGTC_1362 1611-0397 101 µM -0.993973294181209 0.171845574883133 no 2825 0.160117934609747 4047 27816 SGTC_670 4204-0025 119 µM -0.995483628727267 0.171450138642379 no 2826 0.159750551364292 4091 719039 SGTC_48 0382-0018 55 µM -0.996588775406186 0.171161157569189 no 2827 0.159482078255697 4126 762596 SGTC_3197 9113331 49.47 µM -0.997743099879505 0.170859649946757 no 2828 0.159201973939075 4118 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_478 N-arachidonylglycine 10 µM -1.00006194356803 0.170254999625027 no 2829 0.158640265865643 4032 5283389 SGTC_1716 st033144 30.6155 µM -1.00306514887248 0.169473938649721 no 2830 0.157914714310373 4111 674617 SGTC_741 4582-0002 126 µM -1.00357138697625 0.169342505190895 no 2831 0.157792625978692 4067 2912688 SGTC_2698 st077697 67.5 µM -1.00799815693196 0.168195981424049 no 2832 0.156727673517276 4067 3154499 SGTC_487 nimodipine 119 µM -1.00836953712212 0.168100022346549 no 2833 0.156638545793338 4042 4497 L-type voltage-gated calcium channels inhibitor SGTC_2649 anisomycin 9.56 µM -1.01003286659546 0.167670675246699 no 2834 0.156239771922909 4110 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1358 1509-0022 2.48 µM -1.01355982741886 0.166762616813854 no 2835 0.155396417434564 4128 3258434 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.01569994597243 0.166213167321287 no 2836 0.154886146885061 4144 5357218 A potent inhibitor of glutathione S-transferases. SGTC_823 0417-1665 178 µM -1.01586846932579 0.166169950713948 no 2837 0.154846012757876 4096 3429856 SGTC_2444 5485484 36.41 µM -1.01614099592468 0.166100078580682 no 2838 0.154781124616958 4193 6790631 SGTC_3115 9123671 49.47 µM -1.01858125238399 0.165475275932241 no 2839 0.154200904196828 4222 3286988 SGTC_3147 9097027 49.47 µM -1.01914372800521 0.165331475698948 no 2840 0.154067368494746 4119 25236841 SGTC_1688 st021091 57.6 µM -1.01955466511215 0.16522646831963 no 2841 0.1539698574888 4133 3656366 SGTC_1215 3852-0577 11.2 µM -1.01958654320911 0.165218324265859 no 2842 0.153962294862555 4155 2884876 SGTC_442 cape 100 µM -1.02072376983415 0.16492796136325 no 2843 0.153692664770667 4090 5281787 SGTC_402 epigallocatechin gallate 10 µM -1.02164783928742 0.1646922664177 no 2844 0.153473803408631 4054 65064 An antioxidant. SGTC_566 0958-0068 16.5 µM -1.02224658656342 0.164539665344147 no 2845 0.153332103285777 4027 6815365 SGTC_2656 pseudo-anisatin 100 µM -1.02341060896879 0.164243256489005 no 2846 0.153056872717658 4144 6708809 A neurotoxin. SGTC_2322 7413319 38.22 µM -1.02447772782388 0.163971827749668 no 2847 0.152804842680362 4152 1840400 SGTC_794 k038-0031 316 µM -1.02456706429209 0.163949117637891 no 2848 0.152783755860802 4101 6624242 SGTC_2489 cantharidin 73.42 µM -1.02515433501601 0.163799879089446 no 2849 0.152645185578083 4070 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2017 5132927 60.65 µM -1.02587078297107 0.163617933168593 no 2850 0.152476248036451 4120 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3088 9117578 49.47 µM -1.02836456595582 0.162985646899182 no 2851 0.151889184983318 4160 678341 SGTC_818 4072-2707 53.5 µM -1.02950149174703 0.162697912896287 no 2852 0.151622039576372 4026 882871 SGTC_1269 0831-0796 3.05 µM -1.02972214763494 0.162642107454118 no 2853 0.151570227894789 4142 927758 SGTC_3074 9116018 49.47 µM -1.03150450196056 0.162191793962916 no 2854 0.15115214907176 4179 17027303 SGTC_1157 4092-0394 27.6 µM -1.03165528127043 0.162153736707338 no 2855 0.151116816679386 4222 3659885 SGTC_3046 9092212 49.47 µM -1.03201760127405 0.162062309575153 no 2856 0.151031936037579 4179 25236637 SGTC_2787 5284540 71.43 µM -1.03292210738605 0.16183421479841 no 2857 0.15082017604325 4176 736958 SGTC_858 0438-0351 2.77 µM -1.03426850784847 0.161495072475886 no 2858 0.150505327462157 4092 2799119 SGTC_657 3534-0529 86.7 µM -1.03456845692863 0.161419582019302 no 2859 0.15043524564359 4185 1049549 SGTC_644 1498-1197 63.3 µM -1.03501880693916 0.161306282241253 no 2860 0.150330064123675 4161 6741615 SGTC_358 0075-0058 9.45 µM -1.03883355041786 0.160348644115612 no 2861 0.149441077433553 3952 1069125 SGTC_1852 st056254 31.4 µM -1.03920035695558 0.16025675865164 no 2862 0.149355782256141 4054 442583 SGTC_2095 5432005 200 µM -1.04000630781086 0.160054987932813 no 2863 0.149168485050219 4134 783734 SGTC_2012 4023501 200 µM -1.04009450494812 0.160032917766487 no 2864 0.149147998193436 4162 3477460 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.04084664512043 0.159844785495116 no 2865 0.148973363789916 4137 75037 A free radical scavenger. SGTC_660 4031-1742 102 µM -1.04468837651962 0.158886113654494 no 2866 0.148083509340938 4030 6738706 SGTC_3241 9133421 49.47 µM -1.04541422028498 0.158705409543288 no 2867 0.147915783599649 4179 17018221 SGTC_162 k030-0015 37.8 µM -1.04596856280182 0.158567492704486 no 2868 0.147787773523341 4223 1809920 YMR134W ERG29 SGTC_734 2023-0417 80 µM -1.04814171256837 0.15802758531267 no 2869 0.147286660257771 4135 3935732 SGTC_2047 4141938 200 µM -1.04896395675234 0.1578236182287 no 2870 0.147097353764751 4124 3807862 SGTC_2749 bexarotene 57.39 µM -1.05052536111075 0.157436770107497 no 2871 0.146738318548994 4184 82146 An retinoic acid receptor inhibitor. SGTC_1670 st016595 4.04 µM -1.05164242649942 0.157160392609704 no 2872 0.14648181740279 4154 597879 SGTC_1380 2291-0730 164 µM -1.05198345747524 0.157076080416834 no 2873 0.14640356969417 4170 2999191 SGTC_1857 st056007 79.3 µM -1.05565080222468 0.156171292788445 no 2874 0.145563890896626 4120 619834 SGTC_1701 st028638 40.4 µM -1.05619940283376 0.156036240835059 no 2875 0.145438561775526 4163 3490878 SGTC_1676 st018489 23.4 µM -1.05727654774697 0.155771298285369 no 2876 0.145192696649107 4179 3696235 SGTC_2098 5376439 882.5 nM -1.0586064077622 0.155444605478725 no 2877 0.144889533728017 4191 2844116 SGTC_2635 hydroquinidine 100 µM -1.05937079523809 0.155257031146876 no 2878 0.144715472370112 4078 442912 An experimental heart treatment. SGTC_1567 st069303 68.4 µM -1.05949732459257 0.155225996312939 no 2879 0.14468667351781 4213 5581319 SGTC_990 3985-0011 41.3 µM -1.05962663873169 0.155194282664737 no 2880 0.144657244820377 4143 5399565 YGL099W LSG1 SGTC_1929 genistein trimethyl ether 50.5 µM -1.05995524804567 0.155113712113815 no 2881 0.144582479615962 4147 136420 SGTC_2816 7982706 58.44 µM -1.06161855348607 0.154706315895032 no 2882 0.144204443707342 4187 2981853 SGTC_485 niflumic acid 177 µM -1.06212281334877 0.154582946460155 no 2883 0.144089967325477 4205 4488 A COX2 inhibitor. SGTC_1789 tunicamycin 25 nM -1.06282757226156 0.154410633002818 no 2884 0.143930076622015 4058 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2786 7743617 45.45 µM -1.06356360139077 0.154230809598378 no 2885 0.143763219358495 4115 583674 SGTC_2087 5276107 200 µM -1.06394215394524 0.154138377257515 no 2886 0.143677452618311 4127 144405 SGTC_1432 4049-0298 68.4 µM -1.06662367673929 0.15348467089491 no 2887 0.143070902244685 4186 741646 SGTC_1889 st059080 5.18 µM -1.06973065389127 0.152729546118318 no 2888 0.142370282109056 4126 176925 Isolated from Daphnopsis sellowiana. SGTC_702 1488-0190 94 µM -1.07001737168221 0.152659986164727 no 2889 0.142305744722601 4191 949357 SGTC_457 grayanotoxin iii 135 µM -1.07074251107866 0.152484155542371 no 2890 0.142142611241546 4003 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_60 0986-0278 202 µM -1.07139171308165 0.152326852157631 no 2891 0.141996668697393 4110 3110598 SGTC_835 0312-0010 67.2 µM -1.07598527652218 0.151216897852991 no 2892 0.140966920626687 4153 1626196 SGTC_2597 laccaic acid a 100 µM -1.07728723916487 0.150903282373346 no 2893 0.140675980704675 4179 5491415 A textile dye. SGTC_466 geldanamycin 89.2 µM -1.08026901162383 0.150186668175374 no 2894 0.140011202410321 4110 5288382 HSP90 inhibitor. SGTC_1629 st005085 44.9 µM -1.08072020030914 0.150078431175678 no 2895 0.139910797331241 4123 24207091 SGTC_2680 butyl paraben 22.24 µM -1.08104605206601 0.150000293974484 no 2896 0.13983831449113 4252 7184 An antifungal and steroid mimetic. SGTC_2818 7996756 12.99 µM -1.08164884045144 0.149855820626376 no 2897 0.139704296839687 4190 2241621 SGTC_3349 9149703 23.001 µM -1.08456225264032 0.14915885697884 no 2898 0.139057790527187 4188 4910494 SGTC_1233 0325-0408 14.2 µM -1.08573653523964 0.148878551276481 no 2899 0.138797785865672 4215 12874 SGTC_1328 1441-0025 69.2 µM -1.08613889396683 0.148782587742511 no 2900 0.138708773512936 4151 4562601 SGTC_353 1988-1175 58.3 µM -1.08749870856297 0.148458574660571 no 2901 0.138408234500557 4026 2788357 SGTC_348 k064-0012 10.7 µM -1.08785648126086 0.148373403982328 no 2902 0.138329235274538 4106 5066323 SGTC_1471 k673-0312 37 µM -1.08910006441498 0.14807761324656 no 2903 0.138054880755405 4129 24099884 SGTC_181 1447-1644 8.07 µM -1.09059553986673 0.147722431986907 no 2904 0.137725446491469 4183 534600 SGTC_1777 st045864 34.765 µM -1.09510751647772 0.146654279739203 no 2905 0.136734768043155 4176 4691462 SGTC_2934 9036370 36.88 µM -1.09686920609228 0.146238632835155 no 2906 0.136349285894643 4178 6462800 SGTC_1488 4013-0813 75.9 µM -1.09867010175706 0.14581455429486 no 2907 0.135955994106581 4120 2910057 SGTC_1530 rhein 70.4 µM -1.09980316189902 0.145548163042514 no 2908 0.135708947197666 4265 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_231 b-estradiol 524 µM -1.10055748346205 0.14537099774877 no 2909 0.135544649197383 4171 450 A steroid. SGTC_2372 9071633 200 µM -1.10089621574739 0.14529148790694 no 2910 0.13547091462792 4229 21321366 SGTC_2331 7980721 200 µM -1.10106049184594 0.145252938297506 no 2911 0.135435165233158 4154 2981221 SGTC_1531 st059297 52.4 µM -1.1015566256618 0.145136555564684 no 2912 0.135327236958973 4204 7566702 SGTC_2652 actinonin 100 µM -1.10162604560583 0.145120276087658 no 2913 0.135312140141841 4202 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3259 9138485 49.47 µM -1.10249484896622 0.144916639373098 no 2914 0.135123298332715 4212 17646153 SGTC_82 0054-0107 293.755 µM -1.10275241791989 0.144856305399831 no 2915 0.135067348273429 4156 3104697 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.10296875165449 0.144805643598441 no 2916 0.13502036775495 4236 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_44 0929-0055 61.211 µM -1.10449175759306 0.144449318367656 no 2917 0.134689938526176 4095 1379590 SGTC_75 0159-0059 199.013 µM -1.10620541357577 0.144049095290467 no 2918 0.134318810118552 4291 5377270 SGTC_3028 9087778 49.47 µM -1.11168696699827 0.142773908062256 no 2919 0.133136382699784 4184 17217395 SGTC_1363 1636-0063 10.4 µM -1.11412009885946 0.142210335350045 no 2920 0.132613833612123 4221 6072185 SGTC_1300 1094-0077 113 µM -1.11529074782461 0.141939721585109 no 2921 0.132362924458635 4190 5532636 SGTC_2912 7964298 10.93 µM -1.11569568469022 0.141846195325337 no 2922 0.132276209181228 4210 2975850 SGTC_3156 9099931 49.47 µM -1.11637559381776 0.141689253963487 no 2923 0.132130698011616 4241 18111053 SGTC_1717 st033143 58.0435 µM -1.11642650781288 0.141677506375943 no 2924 0.132119806065227 4276 674616 SGTC_1986 st071812 45 µM -1.11886653173157 0.141115283413168 no 2925 0.131598541467475 4151 11838594 SGTC_1160 4092-0570 10.5 µM -1.11931072862744 0.141013095904757 no 2926 0.131503800196664 4208 4994975 SGTC_553 k007-0256 45.7 µM -1.12341505282353 0.140071270385271 no 2927 0.130630629854088 4277 6287000 SGTC_1603 st002045 67.8 µM -1.12346609471439 0.140059584694295 no 2928 0.130619796293363 4221 5887985 SGTC_2120 5538279 151.968 µM -1.123941629665 0.139950746060326 no 2929 0.130518894604374 4178 2058197 SGTC_1839 st053978 48 µM -1.12523636402977 0.139654703520161 no 2930 0.130244443777253 4230 3788398 SGTC_1614 st002383 48.6 µM -1.12750702278301 0.139136543568913 no 2931 0.12976408647979 4240 1947235 SGTC_3098 9119039 49.47 µM -1.12965963293333 0.138646531748751 no 2932 0.129309836454079 4218 17161528 SGTC_2070 5230947 200 µM -1.1321636584304 0.138078005912169 no 2933 0.128782817834488 4324 2835538 SGTC_1290 0986-0249 10.2 µM -1.13229060035971 0.138049226816196 no 2934 0.12875614029315 4082 53329 SGTC_2105 5350118 200 µM -1.13266289653665 0.137964846875843 no 2935 0.128677922325415 4199 2133313 SGTC_1458 k015-0034 6.33 µM -1.13311208783038 0.137863085699656 no 2936 0.128583592891156 4254 3598957 SGTC_273 hydroxyurea 18.1 mM -1.13846007332232 0.136655470458221 no 2937 0.127464210889905 4307 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1842 st055362 61.2 µM -1.1412559199714 0.136027034813541 no 2938 0.126881719913996 4197 676032 SGTC_2872 9044037 25.97 µM -1.14133713918113 0.136008808407124 no 2939 0.126864826322056 4255 6465195 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.14598469759566 0.134968633935309 no 2940 0.125900741881829 4222 688803 SGTC_1628 st004252 77.7 µM -1.14602057997048 0.134960624350914 no 2941 0.125893318411363 4259 692968 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.14665473528863 0.13481912339835 no 2942 0.125762172521691 4334 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_3008 9078912 71.4286 µM -1.14889608188884 0.134319820912573 no 2943 0.125299416731484 4235 16648731 SGTC_263 alizarin 107.927 µM -1.14906888726601 0.134281378031519 no 2944 0.125263788189204 4269 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1497 4476-2978 41.3 µM -1.14982070218676 0.134114214641786 no 2945 0.12510886336658 4273 1528379 SGTC_757 1066-0008 322 µM -1.15022815340778 0.134023679061897 no 2946 0.125024956739411 4276 6842497 SGTC_1684 st024538 14.6195 µM -1.15040304903272 0.133984830173323 no 2947 0.124988952458591 4195 6732859 SGTC_664 1222-0054 14.9 µM -1.15051541422376 0.133959875011211 no 2948 0.12496582461027 4210 6813991 SGTC_1633 st005664 67.9 µM -1.152025209832 0.133624874584384 no 2949 0.124655357058149 4237 2063822 SGTC_1391 3442-0225 151 µM -1.15224991565869 0.133575065106952 no 2950 0.124609195697637 4215 5227075 SGTC_541 4513-1321 94 µM -1.154282555702 0.133125079515356 no 2951 0.124192172954806 4210 747515 SGTC_591 4299-0174 154 µM -1.1546829930175 0.133036553910783 no 2952 0.124110133238966 4264 5509088 SGTC_2792 7535235 81.82 µM -1.15522842589859 0.132916039000702 no 2953 0.123998448521152 4243 1281891 SGTC_2356 9061756 188.97 µM -1.1613292440662 0.131573167959825 no 2954 0.12275401558298 4282 20104043 SGTC_1185 1319-0113 81.3 µM -1.16583947731703 0.130586445769892 no 2955 0.121839676368602 4321 4672763 SGTC_1230 0170-0365 3.77 µM -1.1685589707225 0.129993969841946 no 2956 0.12129068349643 4307 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.16944018860231 0.129802385190947 no 2957 0.121113162946752 4212 688761 SGTC_1268 0828-0275 2.46 µM -1.17471989979991 0.12865862401122 no 2958 0.120053397629587 4319 745337 SGTC_2511 berberine 10.47 µM -1.17587383689108 0.128409576939918 no 2959 0.119822647587576 4236 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3239 9133757 49.47 µM -1.17881582325223 0.127776141272136 no 2960 0.119235761086544 4301 17036923 SGTC_1349 flufenamic acid 69 µM -1.18057272820393 0.127398901472249 no 2961 0.118886251421617 4205 3371 A non-steroidal anti-inflammatory. SGTC_419 nsc-638432 893 µM -1.18062176504699 0.127388383483595 no 2962 0.118876506673821 4223 368090 SGTC_3102 9121669 49.47 µM -1.18459615324399 0.126537918245049 no 2963 0.118088579350336 4313 41905072 SGTC_1189 1431-2119 7.28 µM -1.18515512124903 0.126418624648922 no 2964 0.117978060226803 4260 3107275 SGTC_417 st075190 100 µM -1.18558592116395 0.126326737858329 no 2965 0.117892932433212 4265 222757 SGTC_2091 4-phenylthiadiazole 200 µM -1.18806236007095 0.125799432474331 no 2966 0.117404421094033 4291 270010 SGTC_367 0335-0881 7.1 µM -1.18817919518669 0.125774592883711 no 2967 0.117381409236003 4232 23828853 SGTC_2213 7173844 200 µM -1.1886900122026 0.125666031419494 no 2968 0.117280836168463 4261 892728 SGTC_1108 betulinic acid 729.144 nM -1.19113244728504 0.125147856206406 no 2969 0.116800796852853 4268 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2409 alverine citrate 63.97 µM -1.19255043047792 0.124847709260396 no 2970 0.116522744518613 4366 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3206 9114350 49.47 µM -1.1930852823792 0.124734626981359 no 2971 0.116417987439132 4140 17087243 SGTC_878 0828-0289 13.7 µM -1.19649402177944 0.12401560834208 no 2972 0.115751915060006 4230 745350 YLR208W SEC13 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.19653026234619 0.12400797959246 no 2973 0.115744848173981 4271 641818 YHR062C RPP1 SGTC_554 4483-2211 187 µM -1.19743048854576 0.123818584623909 no 2974 0.115569403010303 4343 747107 SGTC_736 0958-0254 92.6 µM -1.19885934593764 0.123518388989184 no 2975 0.115291320947605 4358 6812352 SGTC_1072 oxiconazole 14.9 nM -1.19973027122391 0.123335662284661 no 2976 0.115122056265574 4264 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1025 k007-0731 70 µM -1.20305086403734 0.12264071478897 no 2977 0.11447831902796 4251 6256118 SGTC_1003 4049-0218 100 µM -1.20355947707222 0.122534513209834 no 2978 0.114379944954673 4310 295161 SGTC_1818 st052136 56.3 µM -1.20573634454847 0.122080698852525 no 2979 0.113959583290351 3966 674169 SGTC_923 1900-2434 73.3 µM -1.20856401402258 0.121492975044929 no 2980 0.113415194333581 4280 5910570 SGTC_2222 6885208 172.143 µM -1.2092513426614 0.121350416551199 no 2981 0.113283149021854 4270 609514 SGTC_2326 6164455 177.58 µM -1.20966792675199 0.121264070319627 no 2982 0.1132031708692 4255 2888790 SGTC_1741 st038134 10.228 µM -1.21553594209921 0.120052383914241 no 2983 0.112080874527155 4350 1272587 SGTC_2611 pyromycin 23.93 µM -1.2191236093948 0.119315783423097 no 2984 0.111398640105417 4275 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_873 0591-4978 488 µM -1.21923967731304 0.119292006364103 no 2985 0.111376618257467 4357 3305145 SGTC_2144 5628481 200 µM -1.21927930844444 0.11928388850631 no 2986 0.111369099660349 4284 2818399 SGTC_432 NS 1619 61.3 µM -1.21973885694646 0.119189785185809 no 2987 0.111281943212068 4295 4552 A K+/calcium channel activator. SGTC_3103 9120822 49.47 µM -1.22102732318414 0.118926221015593 no 2988 0.111037837376318 4300 17141819 SGTC_151 3013-0144 2.285 µM -1.22224594725365 0.118677322495783 no 2989 0.110807316563541 4128 906558 YHR107C CDC12 SGTC_1460 k062-0059 9.15 µM -1.22227774952359 0.118670831955636 no 2990 0.110801305287037 4186 1373085 SGTC_781 4335-2806 94.4 µM -1.22450385608453 0.11821712788426 no 2991 0.110381106272622 4363 845254 SGTC_1718 roemerine 11.9335 µM -1.22501839888797 0.118112433364406 no 2992 0.110284144160195 3984 235224 An aporphine alkaloid with mutagenic activity. SGTC_1816 st051957 91.6 µM -1.22572593074497 0.117968578280116 no 2993 0.110150914332835 4293 674121 SGTC_1897 st060201 15 µM -1.23094788781226 0.116910684650423 no 2994 0.109171177702219 4318 611878 SGTC_1390 3413-2614 145 µM -1.23120226853008 0.116859323066115 no 2995 0.109123611590073 4331 3421432 SGTC_847 0342-0274 5.54 µM -1.23294753037242 0.11650737144674 no 2996 0.108797670346754 4308 18097 SGTC_890 0929-0006 47.2 µM -1.23366174643187 0.116363558775231 no 2997 0.108664486985719 4308 1378169 SGTC_590 k048-0076 22.4 µM -1.23459936944625 0.116174952721117 no 2998 0.108489821901899 4334 6832814 SGTC_750 4073-0104 132 µM -1.2346914169965 0.116156448745089 no 2999 0.108472685719848 4028 22330957 SGTC_2838 9002687 71.43 µM -1.23655582164722 0.115782104600273 no 3000 0.108126014881268 4301 6457060 SGTC_3227 9130768 49.47 µM -1.23751929838834 0.115588989238355 no 3001 0.107947177148755 4371 17720899 SGTC_2769 toremifene 3.73 µM -1.23949572707509 0.115193558332159 no 3002 0.107580985097617 4345 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3337 9144342 33.5465 µM -1.2411236014348 0.114868586915098 no 3003 0.107280046014205 4310 17682949 SGTC_2735 sertaconazole 140 nM -1.24173167335009 0.114747365399213 no 3004 0.107167789860966 4458 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3172 9105863 49.47 µM -1.24251226485633 0.114591884882829 no 3005 0.107023809060421 4400 2348785 SGTC_1612 st002233 45.4 µM -1.24450090935339 0.114196458523714 no 3006 0.106657632446358 4331 1035021 SGTC_651 3253-0966 34.4 µM -1.24472818596751 0.114151328305992 no 3007 0.106615840793722 4333 781462 SGTC_2832 7992762 51.95 µM -1.24585830060942 0.113927110563154 no 3008 0.106408210674279 4268 2985177 SGTC_848 0368-0089 85.6 µM -1.24864580502896 0.11337540437917 no 3009 0.105897325525939 4319 762535 SGTC_2671 danthron 100 µM -1.24865283648144 0.11337401511941 no 3010 0.10589603906859 4317 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1376 2910-0861 41.3 µM -1.25017235816486 0.113074075956051 no 3011 0.105618295996857 4262 1112859 SGTC_3113 9123498 49.47 µM -1.25074697683928 0.112960799368812 no 3012 0.105513402719159 4429 8897275 SGTC_3051 9093778 49.47 µM -1.25136902407331 0.112838264350695 no 3013 0.10539993658165 4408 17217378 SGTC_531 3788-1495 174 µM -1.25306030117139 0.11250558512367 no 3014 0.105091881083442 4310 2896655 SGTC_1367 1812-0510 76.9 µM -1.25345849555797 0.112427361108072 no 3015 0.105019447343995 4382 1142582 YDR527W RBA50 SGTC_1606 st000094 49.2 µM -1.25473106385238 0.112177629674349 no 3016 0.104788202503756 4352 1242210 SGTC_2607 solasodine 47.35 µM -1.25576887139162 0.111974261891948 no 3017 0.104599890367825 4301 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2319 6033012 152.6 µM -1.26011933482755 0.111124618135644 no 3018 0.103813158177849 4286 847246 SGTC_389 tpck 16.7 µM -1.2601887858144 0.111111091926891 no 3019 0.103800633654156 4376 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2904 7225135 42.03 µM -1.26120590292069 0.110913134214976 no 3020 0.103617336224282 4409 4446116 SGTC_1198 1612-1005 86.7 µM -1.26352190776974 0.110463321745408 no 3021 0.103200839241607 4407 6998509 SGTC_2603 homopterocarpin 100 µM -1.26508977859019 0.110159554525677 no 3022 0.102919573278917 4314 101795 A weak amylase inhibitor. SGTC_1447 4239-0816 81.9 µM -1.2664004165197 0.109906085083524 no 3023 0.102684880942263 4350 1341554 SGTC_452 diindolylmethane 8 µM -1.26686459780438 0.109816415673997 no 3024 0.102601854619952 4338 3071 Inhibits expression of several cancer promoting factors. SGTC_2755 lomerizine 42.69 µM -1.26784584044652 0.109627034462631 no 3025 0.102426504153622 4291 3949 A calcium channel blocker. SGTC_1129 3453-1384 223 µM -1.27327299967206 0.108583819550962 no 3026 0.101460592171818 4387 1084452 SGTC_209 4077-0173 175.592 µM -1.27692200942278 0.107886429083477 no 3027 0.100814891461586 4338 15993494 SGTC_2099 5377090 177.372 µM -1.27733233432686 0.107808210940866 no 3028 0.100742471363445 4366 2243829 SGTC_792 4534-1957 155 µM -1.27815322671362 0.107651851032546 no 3029 0.10059770224265 4308 1717904 SGTC_2552 juarezic acid 87.02 µM -1.27873325028533 0.107541469292665 no 3030 0.100495503266231 4291 1549512 SGTC_2304 7443016 91.4 µM -1.28037505808839 0.107229466294223 no 3031 0.100206630783571 4286 939854 SGTC_3283 9109332 35.8195 µM -1.28274276085644 0.106780667059816 no 3032 0.0997911067456999 4188 17027281 SGTC_1881 5652484 16 µM -1.28477759682674 0.106396047227272 no 3033 0.0994350066102837 4339 2255129 SGTC_1958 st076513 41.9 µM -1.28529820960585 0.106297803156393 no 3034 0.0993440477966218 4298 732122 YGL099W LSG1 SGTC_3324 9138759 60.749 µM -1.28621569039995 0.106124826207636 no 3035 0.0991838983101798 4388 45595710 SGTC_2271 7849410 118.62 µM -1.29024848881743 0.105366915145695 no 3036 0.0984821977463787 4291 972430 SGTC_885 0865-0106 16.8 µM -1.29087563632715 0.105249403765529 no 3037 0.0983734024572876 4317 2793380 SGTC_2234 tolnaftate 200 µM -1.29345995594057 0.104766168932444 no 3038 0.0979260125934316 4453 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_319 1348-1596 45.5 µM -1.29489813502725 0.104497944634808 no 3039 0.0976776859740441 4439 5380505 SGTC_10 0279-0212 42.575 µM -1.29498376808694 0.104481989545464 no 3040 0.0976629145153411 4350 39851 YBR002C RER2 SGTC_3165 9101544 49.47 µM -1.29610005435234 0.104274165347584 no 3041 0.09747050813483 4365 5002184 SGTC_2974 9094440 9.66 µM -1.29624565576814 0.104247080159884 no 3042 0.0974454323585446 4352 25236134 SGTC_1915 st067105 30.6 µM -1.29802025720597 0.103917373529522 no 3043 0.0971401870518505 4304 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_321 4534-3890 65.3 µM -1.29979180784511 0.103588988686036 no 3044 0.0968361670103143 4353 699746 SGTC_2023 5144124 124 µM -1.3010792133476 0.103350820681528 no 3045 0.0966156710245354 4350 2830192 SGTC_592 k241-0073 46.5 µM -1.30234654514325 0.103116754806299 no 3046 0.0963989735348204 4404 4230158 SGTC_454 lyso-paf C-16 6.67 µM -1.30829448300041 0.102023361885163 no 3047 0.0953867228393636 4384 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2181 6316240 54.2555 µM -1.30976914764849 0.101753588199971 no 3048 0.0951369716273624 4379 12779990 SGTC_675 1309-0189 238 µM -1.31000210017228 0.101711019638354 no 3049 0.0950975625583899 4368 4246530 SGTC_2328 6201408 200 µM -1.31088335185342 0.101550101478559 no 3050 0.0949485881280549 4357 2890418 SGTC_2676 harmalol 100 µM -1.31184705617703 0.101374339644621 no 3051 0.0947858720751854 4337 5459187 A monoamine oxidase inhibitor SGTC_1723 st034307 2.5525 µM -1.31219264461654 0.101311364723937 no 3052 0.0947275714969054 4381 867466 SGTC_2715 st079500 56.4 µM -1.31344002530279 0.101084297639749 no 3053 0.0945173589115697 4349 28246688 SGTC_3029 9088683 49.47 µM -1.31456957307153 0.100879000508744 no 3054 0.0943273008094145 4401 25236615 SGTC_2897 9048598 12.99 µM -1.31481510769836 0.100834414445462 no 3055 0.0942860243859262 4351 6467404 SGTC_843 0310-0051 143 µM -1.31796700746347 0.100263343932143 no 3056 0.0937573463007509 4403 2065037 SGTC_2706 st078239 82.5 µM -1.32167620923925 0.099594327801774 no 3057 0.0931379970502557 4373 15434492 SGTC_175 3793-3120 23.7 µM -1.32292116636527 0.0993705119404493 no 3058 0.0929307977824503 4380 5322297 SGTC_137 0438-0332 85.389 µM -1.32365317907115 0.0992390839629631 no 3059 0.0928091274876915 4340 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1728 st035614 33.7865 µM -1.32989797409413 0.0981230370385484 no 3060 0.091775944509354 4322 15945546 SGTC_1264 0783-0040 158 µM -1.33893708123806 0.0965239297074353 no 3061 0.0902955783566172 4311 2855798 SGTC_1236 0330-0013 258 µM -1.33932532059635 0.096455677713132 no 3062 0.0902323945946416 4401 4617066 SGTC_888 0916-0002 6.97 µM -1.34237210532786 0.0959212874808142 no 3063 0.0897376872983515 4431 2802138 YIL048W NEO1 SGTC_473 2-arachidonoylglycerol 10 µM -1.35114158353619 0.0943953244627548 no 3064 0.0883250415229046 4227 5282280 An endocannabinoid. SGTC_980 1473-0395 201 µM -1.35414838892528 0.0938762580211484 no 3065 0.0878445204846494 4300 768876 SGTC_976 1348-1067 47.6 µM -1.3553245337823 0.0936737937194201 no 3066 0.0876570908723806 4433 5310671 YGL099W LSG1 SGTC_2449 5812982 45.77 µM -1.35595717992398 0.0935650219859602 no 3067 0.0875563963238689 4330 776185 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.35906219975814 0.093032523637308 no 3068 0.087063439836847 4413 6708561 SGTC_3267 9137951 49.47 µM -1.36020386783442 0.0928372964724953 no 3069 0.0868827094733153 4452 16643986 SGTC_2350 9023895 38.85 µM -1.36279715717509 0.0923949654619762 no 3070 0.0864732236644766 4383 2997209 SGTC_1669 st015249 58.4 µM -1.36299459422044 0.0923613531045324 no 3071 0.0864421071509445 4528 722793 SGTC_721 1187-1332 279 µM -1.36432250825561 0.0921355195488833 no 3072 0.0862330424447309 4386 25730 SGTC_1951 sophoraflavanone G 9.2 µM -1.36974984116621 0.0912167615960217 no 3073 0.0853825022275998 4361 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1011 4112-3381 17.4 µM -1.37031684070385 0.0911211712508003 no 3074 0.0852940091535884 4461 2877139 SGTC_755 1995-0008 37.3 µM -1.37454771778856 0.0904102328177098 no 3075 0.0846358534437498 4373 689533 SGTC_1187 1391-0724 117 µM -1.37767019040088 0.0898881933840061 no 3076 0.0841525694914078 4475 6997986 SGTC_855 0428-0020 25 µM -1.37888219552604 0.0896861655618761 no 3077 0.0839655392569983 4442 6812414 SGTC_3053 9095903 49.47 µM -1.38233679090555 0.0891121754636997 no 3078 0.0834341572098228 4532 17174018 SGTC_2598 perillyl alcohol 100 µM -1.38272158308739 0.0890484108357114 no 3079 0.0833751256981729 4443 10819 An apoptosis inducer. SGTC_2731 amoxapine 43.43 µM -1.38325375026026 0.088960280393707 no 3080 0.0832935369217077 4578 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1089 terbinafine 2.25 µM -1.38657878352447 0.08841110239632 no 3081 0.0827851207672829 4433 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_6 0844-0013 19.835 µM -1.39260535310181 0.0874221712087438 no 3082 0.0818695816850771 4550 1584900 SGTC_2971 9092186 9.93 µM -1.39396324054834 0.0872004925266705 no 3083 0.0816643526917946 4397 25236400 SGTC_2822 7994718 71.43 µM -1.39600694905253 0.086867643403907 no 3084 0.081356201281285 4434 1018011 SGTC_1588 farnesol 29.9 µM -1.39792758666961 0.0865557043188056 no 3085 0.0810674067873743 4447 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_926 2268-1401 59.4 µM -1.39812702226578 0.0865233611693272 no 3086 0.0810374632759446 4405 2931578 SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.40061428264468 0.0861207523598536 no 3087 0.0806647237936906 4481 165506 SGTC_1082 camptothecin 424.86 nM -1.40113907607567 0.0860359842317037 no 3088 0.0805862442137473 4306 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1467 k284-1082 293 µM -1.40116143371311 0.0860323742642343 no 3089 0.0805829020499815 4397 3334705 SGTC_3141 9094609 49.47 µM -1.40298136685885 0.0857388993900961 no 3090 0.0803111976961761 4399 25236309 YDL196W YDL196W SGTC_512 prima-1 270 µM -1.4037050763233 0.0856224054906407 no 3091 0.0802033451038658 4446 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2434 5670830 169.91 µM -1.40391131242558 0.0855892298331104 no 3092 0.0801726303111707 4456 1549830 SGTC_971 1315-0384 26.7 µM -1.40469850712038 0.0854626881995233 no 3093 0.0800554749463367 4463 6769120 SGTC_2399 5884133 200 µM -1.41575867418757 0.0836995517680651 no 3094 0.0784230864639223 4400 722445 SGTC_1731 st035964 63 µM -1.41820630979267 0.0833130854902155 no 3095 0.0780652701355533 4364 6739575 SGTC_2150 5556613 200 µM -1.41838411981472 0.0832850627572996 no 3096 0.0780393246792894 4477 743190 SGTC_688 0527-0193 473 µM -1.41847628859064 0.0832705398126379 no 3097 0.0780258782880286 4485 4007154 SGTC_1316 1272-0050 65.9 µM -1.42252120445753 0.082635059979683 no 3098 0.0774375001422771 4429 7340392 SGTC_1472 k841-0093 193 µM -1.42289269799427 0.0825768796909948 no 3099 0.0773836316685148 4549 X1472 SGTC_215 1287-0124 461.5 µM -1.42424912058384 0.0823647096520317 no 3100 0.0771871850873484 4465 5560863 SGTC_999 SEC7.066 22.7 µM -1.43088478034012 0.0813326800187101 no 3101 0.0762316198378927 4410 740511 YDR170C SEC7 SGTC_1905 st060207 84.5 µM -1.4320022524698 0.0811598459159424 no 3102 0.0760715883432554 4448 1948547 SGTC_2984 9022109 38.96 µM -1.43202180808735 0.0811568238108148 no 3103 0.0760687900915618 4471 6459207 SGTC_1978 st071761 42 µM -1.43286197561147 0.0810270653588097 no 3104 0.0759486428604794 4462 5147680 SGTC_1478 0453-0656 35.7 µM -1.43365648137808 0.0809045031786494 no 3105 0.0758351584209798 4480 5258496 SGTC_2092 5303694 80.6725 µM -1.43471191994389 0.0807419054498957 no 3106 0.0756846030369257 4471 1963699 SGTC_89 0302-0250 142.109 µM -1.43720744804184 0.0803584334472923 no 3107 0.0753295286587097 4533 4203518 YLR208W SEC13 SGTC_1475 4092-1048 11.7 µM -1.44133254993936 0.0797275750378236 no 3108 0.0747453778623725 4466 2881759 SGTC_2333 9017922 200 µM -1.44678521926146 0.0788994477672017 no 3109 0.0739785438765499 4475 3163164 SGTC_1699 st031318 29.054 µM -1.45055716583749 0.0783304053405161 no 3110 0.0734516050377598 4515 5340658 SGTC_1594 piperine 70.1 µM -1.45192382728705 0.0781249982729056 no 3111 0.0732613932335901 4463 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_833 3852-0053 558 µM -1.45222285375184 0.078080109594902 no 3112 0.0732198250499505 4530 3123681 SGTC_1745 st081495 74 µM -1.45350850554197 0.0778873354843983 no 3113 0.0730413099305497 4325 13842402 YBL026W LSM2 SGTC_2612 dictamnine 15.46 µM -1.45420586706649 0.0777829224110551 no 3114 0.0729446194365974 4402 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1442 4112-3290 3 µM -1.45423494102411 0.0777785715950716 no 3115 0.0729405904059158 4465 704353 SGTC_3219 9131112 49.47 µM -1.45656528927681 0.0774304435628797 no 3116 0.0726182075050243 4335 17612988 YMR079W SEC14 SGTC_2692 st077426 47.7 µM -1.45800923112327 0.0772153293410144 no 3117 0.0724189993006036 4459 25238571 SGTC_1682 st012968 530 nM -1.45859944691369 0.0771275315674958 no 3118 0.0723376929662331 4449 24207270 SGTC_3192 9110362 49.47 µM -1.45917816280297 0.0770415181432152 no 3119 0.0722580387575134 4470 16649480 SGTC_2373 9071805 200 µM -1.4598331862984 0.0769442512424191 no 3120 0.0721679627190137 4482 10149009 SGTC_629 3448-6466 76.7 µM -1.4631741167489 0.0764495956187627 no 3121 0.0717098706634586 4485 573744 SGTC_2930 9013230 14.89 µM -1.46996283953408 0.0754519200927862 no 3122 0.0707859093273927 4461 2995857 SGTC_643 k048-0106 28.4 µM -1.47553232369176 0.0746408595239157 no 3123 0.0700347423434097 4500 6763920 SGTC_2273 7815444 169.05 µM -1.4824207599865 0.0736469497528952 no 3124 0.0691141867496065 4419 2824616 SGTC_398 bronopol 33.3 µM -1.48318069808292 0.0735379234226337 no 3125 0.0690132040236066 4417 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2945 9067681 61.76 µM -1.500149954462 0.0711354100436039 no 3126 0.0667877817116718 4529 16456930 SGTC_2690 usnic acid 100 µM -1.50040428287953 0.0710998661570949 no 3127 0.0667548553972676 4495 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2049 5262831 67.185 µM -1.50616798550834 0.0702980066720573 no 3128 0.0660120278052725 4444 763417 SGTC_1658 st012944 20 µM -1.51051703557663 0.0696975741424178 no 3129 0.0654557729109273 4348 24207260 SGTC_2185 6113692 200 µM -1.51404002103203 0.0692140892792154 no 3130 0.0650078446854332 4499 874150 SGTC_1321 1326-2144 215 µM -1.51441652959756 0.0691625714902923 no 3131 0.0649601147567464 4471 3513030 SGTC_1459 k035-0031 35.7 µM -1.51839370767511 0.0686201759503672 no 3132 0.0644575884941669 4241 3877128 YMR208W ERG12 SGTC_2287 7945887 168.79 µM -1.52521344378993 0.0676977643061692 no 3133 0.0636029342345067 4520 1245853 SGTC_128 0906-2981 13.371 µM -1.52557688909621 0.0676488762295038 no 3134 0.0635576356815379 4491 6740226 SGTC_144 4161-2749 112.381 µM -1.5256221788575 0.0676427860847481 no 3135 0.0635519926835362 4501 797501 YMR168C CEP3 SGTC_2956 9076196 2.52 µM -1.52619832699982 0.0675653480200961 no 3136 0.0634802400000583 4498 16423868 SGTC_2280 7785178 200 µM -1.53530440686769 0.0663505090122108 no 3137 0.0623545360856836 4503 2954328 SGTC_2877 9040724 71.43 µM -1.53545445220673 0.0663306341058375 no 3138 0.0623361185363086 4476 6463895 SGTC_95 0471-0001 561.058 µM -1.5376108453004 0.0660455086698327 no 3139 0.0620718970589065 4502 4015405 SGTC_2053 5265679 138 µM -1.54016416698603 0.0657091289068596 no 3140 0.0617601709729864 4430 764595 SGTC_1029 k015-0030 64.7 µM -1.5405327257615 0.065660684114585 no 3141 0.0617152760369784 4533 2208316 SGTC_1807 st050092 58.9 µM -1.54367818173157 0.0652483590974868 no 3142 0.0613331572347603 4517 5008496 SGTC_542 3381-0244 89.3 µM -1.54807016698282 0.0646759959312167 no 3143 0.0608027019172519 4535 1112843 SGTC_2464 5717415 7.67 µM -1.54841700248194 0.0646309630055741 no 3144 0.0607609651279811 4484 5285744 SGTC_1934 st074720 32.6 µM -1.55243985841991 0.0641104154279959 no 3145 0.0602785062857162 4465 17250992 SGTC_1209 2323-2347 50.3 µM -1.55458051354973 0.0638347517383452 no 3146 0.0600230038393858 4542 5412760 SGTC_3185 9108267 49.47 µM -1.5558105766732 0.0636767674789173 no 3147 0.059876571169526 4514 4910486 SGTC_91 0417-1751 58.384 µM -1.55798382727883 0.0633983877930854 no 3148 0.0596185409781566 4607 6795624 SGTC_573 3702-0553 84.7 µM -1.55970057767892 0.0631791533751216 no 3149 0.0594153277898182 4467 1222756 SGTC_492 tmb-8 126 µM -1.56258785328755 0.0628117711042241 no 3150 0.0590747835729716 4555 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2354 9060492 162 µM -1.57301625837758 0.0614986918510367 no 3151 0.0578575268100426 4540 6471895 SGTC_1337 1486-1011 40.3 µM -1.574488183994 0.0613150955094807 no 3152 0.0576873155555693 4526 X1337 SGTC_2762 leflunomide 42.06 µM -1.57552763078461 0.0611857013295973 no 3153 0.0575673528991571 4512 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2732 terfenadine 20 µM -1.57637321391646 0.0610805974977843 no 3154 0.0574699088722291 4608 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2826 7992541 19.48 µM -1.57914408640049 0.060737173733073 no 3155 0.0571515057404433 4530 2985066 SGTC_1229 0139-0193 12.2 µM -1.57956770729611 0.060684803223781 no 3156 0.0571029497344402 4596 3090752 SGTC_1814 st052110 31.539 µM -1.58516877970506 0.0599956816943747 no 3157 0.0564639959265809 4484 674163 SGTC_783 0848-0141 92.7 µM -1.58719574851096 0.0597478115020729 no 3158 0.0562341586889655 4473 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1513 0337-0559 19 µM -1.59000489336971 0.0594056193396651 no 3159 0.0559168510182644 4525 775073 SGTC_746 1095-0025 46.6 µM -1.59027651035848 0.059372614310494 no 3160 0.0558862454889229 4554 6749286 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.59085120590364 0.0593028286477546 no 3161 0.0558215329354628 4491 676296 Flavone; oxidizing agent. SGTC_1283 0922-0125 16.4 µM -1.59168617474921 0.0592015524460063 no 3162 0.0557276181435329 4547 3360884 SGTC_693 4161-2696 114 µM -1.59185500984066 0.0591810903612595 no 3163 0.0557086432424988 4578 805759 SGTC_3015 9080845 49.47 µM -1.59468120883973 0.0588393901240635 no 3164 0.0553917711107286 4580 5296973 SGTC_894 0960-0238 55.9 µM -1.59617288909662 0.0586596645047539 no 3165 0.0552250993575193 4543 6741907 YDL195W SEC31 SGTC_1764 st044502 93.5 µM -1.59926855666836 0.0582880572616427 no 3166 0.0548804714906562 4561 8407 SGTC_630 4356-0227 183 µM -1.59979175230156 0.0582254353727593 no 3167 0.0548223945566018 4494 779312 SGTC_1153 4055-0057 267 µM -1.60075293463829 0.0581105281044226 no 3168 0.0547158258544633 4578 882706 SGTC_525 k781-2675 26.7 µM -1.60352518585725 0.0577801094096457 no 3169 0.0544093766028271 4490 3651118 YDL195W SEC31 SGTC_2569 tetrandrine 100 µM -1.60806344585883 0.0572423943119249 no 3170 0.0539106420045658 4543 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_262 fenpropimorph 62.5 µM -1.60977649840986 0.0570404503234038 no 3171 0.053723328801538 4582 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_106 0092-0003 11.579 µM -1.61184609541531 0.0567972235380258 no 3172 0.0534977173185233 4480 1072148 SGTC_3104 9120930 49.47 µM -1.61482502337066 0.0564485637472931 no 3173 0.0531742962751854 4582 17014836 SGTC_2589 lobaric acid 100 µM -1.61553221708421 0.0563660406181886 no 3174 0.0530977446666483 4476 73157 A novel microtubule depolymerizer. SGTC_1964 st076914 61 µM -1.6177482190081 0.0561080689094715 no 3175 0.052858434874108 4579 24208661 SGTC_2868 9035608 32.47 µM -1.6178548900023 0.0560956745327196 no 3176 0.0528469369120236 4546 6462614 SGTC_1135 dihydrocapsaicin 536.708 nM -1.62369102036116 0.0554208441627778 no 3177 0.0522208842226054 4469 107982 A Capsaicinoid. SGTC_405 ebelactone b 50 µM -1.6242548231954 0.0553559927607473 no 3178 0.0521607173405573 4507 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_107 0358-0022 2.6945 µM -1.62552813884065 0.055209750168845 no 3179 0.0520250365584014 4577 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2066 5222451 176 µM -1.63152410169274 0.0545252008328211 no 3180 0.0513898892567101 4502 2281147 SGTC_2673 kobusone 100 µM -1.64480018893113 0.053033381031134 no 3181 0.0500055116066706 4668 6710676 An epoxy ketone and protein crosslinker. SGTC_1548 st061468 90.8 µM -1.64585058898583 0.0529167441599162 no 3182 0.0498972619600334 4618 390799 SGTC_396 dithiazanine 1.25 µM -1.64705603674599 0.0527831415570937 no 3183 0.0497732641782305 4525 10578 An antihelmenthic. SGTC_501 nsc-95397 161 µM -1.65297981062005 0.052130480403698 no 3184 0.0491674862797969 4564 262093 SGTC_1512 0259-0544 12.2 µM -1.65687213642981 0.0517051383506199 no 3185 0.0487726643992107 4539 18476 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.65951711016202 0.0514176809216752 no 3186 0.0485058178728317 4510 5711223 A potent inhibitor of glutathione S-transferases. SGTC_960 1222-0186 7.7 µM -1.6599432392805 0.0513714880521427 no 3187 0.0484629358903473 4559 3126296 SGTC_1422 4031-0024 15.5 µM -1.66155018023873 0.0511975907418692 no 3188 0.0483014997798659 4520 782427 SGTC_2440 5628896 157.78 µM -1.66528716452255 0.0507949989081027 no 3189 0.0479277390327743 4553 5522048 SGTC_1605 st000082 49.1 µM -1.66629355235308 0.0506870109361401 no 3190 0.0478274801592365 4537 1114022 SGTC_1304 1165-0502 251 µM -1.6699998855003 0.0502908877629271 no 3191 0.0474596931298853 4572 767425 SGTC_636 0kpi-0074 126 µM -1.67215385071287 0.0500618136310846 no 3192 0.0472469940128055 4593 616434 SGTC_1553 gossypol 38.6 µM -1.67401220631286 0.0498648467873368 no 3193 0.0470641002221934 4518 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3257 9139206 32.98 µM -1.67721370751917 0.049526970303346 no 3194 0.0467503497630474 4564 4910041 SGTC_672 1441-0018 53.7 µM -1.67902398327393 0.0493367296408419 no 3195 0.0465736848576312 4583 251141 SGTC_2231 micatex 6.853 µM -1.68249168262449 0.048973940940751 no 3196 0.046236768205625 4601 20737 An antifungal of unknown mechanism. SGTC_2591 skatole 100 µM -1.68533149833354 0.0486784311681899 no 3197 0.0459623159265318 4568 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1425 4048-4433 7.33 µM -1.68566292091927 0.048644036581501 no 3198 0.0459303712576572 4654 23734946 SGTC_1396 3511-0007 98.6 µM -1.69624331536671 0.0475561911560334 no 3199 0.0449199052446077 4603 X1396 SGTC_2007 4011539 71.82 µM -1.69646369461798 0.0475337413019638 no 3200 0.0448990500346473 4560 45595301 SGTC_624 k048-0052 28 µM -1.7062015532677 0.0465502003434957 no 3201 0.043985279827953 4587 6835531 SGTC_1724 st037281 8.293 µM -1.70653594205894 0.0465167187448417 no 3202 0.0439541701584977 4540 574124 YDL195W SEC31 SGTC_1257 0669-0121 16 µM -1.70706198743883 0.0464640861249675 no 3203 0.0439052657464472 4579 4307855 SGTC_1237 0330-0133 46.1 µM -1.70807314996166 0.0463630501510229 no 3204 0.0438113851233422 4538 X1237 YHR072W ERG7 SGTC_1493 4348-0038 111 µM -1.71655881877951 0.0455220916410308 no 3205 0.0430299061481777 4591 800424 SGTC_1778 st046819 58.9 µM -1.71711958157302 0.0454669530429567 no 3206 0.0429786625313368 4632 671715 SGTC_1013 4112-3890 241 µM -1.72007946574958 0.0451768033340691 no 3207 0.042708998882982 4576 705171 SGTC_2168 5727979 200 µM -1.72203614578451 0.0449858144160189 no 3208 0.0425314854560602 4519 695210 SGTC_1657 st012939 43.4 µM -1.72430970761979 0.0447647119681794 no 3209 0.0423259738736469 4583 24207257 SGTC_1162 k048-0130 20.1 µM -1.728714498127 0.0443388392067431 no 3210 0.0419301026257734 4595 6797406 SGTC_870 0573-2213 57.6 µM -1.72996288833628 0.044218735501083 no 3211 0.0418184530023045 4593 3916321 SGTC_268 camptothecin 39.6153 µM -1.73075631168969 0.0441425391250071 no 3212 0.0417476184939095 4553 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1439 4092-1168 46 µM -1.73709406745719 0.0435376860204543 no 3213 0.0411852841740175 4621 2886240 SGTC_2119 5528445 120.635 µM -1.73947941566006 0.0433117766537365 no 3214 0.040975234942756 4607 791935 SGTC_2733 amorolfine 100 µM -1.74489960413268 0.0428019647506794 no 3215 0.0405011731482805 4739 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_825 1988-2224 89.6 µM -1.74846655801692 0.0424691184328372 no 3216 0.0401916357504081 4600 1180859 SGTC_2154 5570129 200 µM -1.74875439580435 0.0424423507039093 no 3217 0.0401667414405573 4653 673366 SGTC_2937 9044753 11.33 µM -1.75450616540547 0.0419103147988921 no 3218 0.0396719071990196 4550 6465530 YGL099W LSG1 SGTC_294 k038-0071 157 µM -1.75714957143273 0.0416676186449864 no 3219 0.0394461590827552 4639 24152826 SGTC_1949 st076024 69.1 µM -1.76190941069831 0.0412334799504861 no 3220 0.0390423021819349 4578 2921930 SGTC_2351 9026858 72.31 µM -1.76818415273951 0.0406667800590531 no 3221 0.0385150613026949 4515 1409300 SGTC_706 4262-0057 46.9 µM -1.77115835950308 0.040400383027314 no 3222 0.038267185773077 4609 883298 SGTC_76 0433-0009 400.328 µM -1.77208371372454 0.0403177894935336 no 3223 0.0381903309981797 4654 2841569 SGTC_393 acivicin 6.25 µM -1.77240992443515 0.0402887059011016 no 3224 0.0381632677782862 4488 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_165 k038-0023 64.381 µM -1.77284168967719 0.0402502377088495 no 3225 0.0381274715555798 4575 46368543 SGTC_1056 3448-1962 115 µM -1.77472180597508 0.0400830761085867 no 3226 0.0379719164799625 4576 715507 SGTC_1156 4092-0367 4.88 µM -1.77489880344332 0.0400673683135008 no 3227 0.0379572989558668 4636 1357585 SGTC_2683 piperine 63.03 µM -1.78883414045941 0.038846277061385 no 3228 0.0368207654457019 4666 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2824 7998404 51.95 µM -1.79004577892915 0.0387415545147807 no 3229 0.0367232761341721 4602 837851 SGTC_2484 5809818 12.04 µM -1.79235019787151 0.0385430170602976 no 3230 0.0365384435108939 4590 2870548 SGTC_2264 7948757 110.76 µM -1.80121643383856 0.0377868641874444 no 3231 0.0358343865568542 4584 2971411 SGTC_369 0957-0393 4.5 µM -1.80790418518875 0.0372245492818046 no 3232 0.0353107071426816 4620 6997992 SGTC_942 3253-1115 227 µM -1.81067225225999 0.0369938159527702 no 3233 0.035095800264232 4633 46497897 SGTC_1710 st031758 61.5 µM -1.82772696726366 0.0355978790800842 no 3234 0.0337952693837 4664 5394341 SGTC_3036 9090181 49.47 µM -1.83218159237181 0.0352404653477964 no 3235 0.0334621852002387 4681 25236586 SGTC_1819 st053448 58.6 µM -1.832215803337 0.0352377318878694 no 3236 0.0334596376514312 4594 2857616 SGTC_2366 9070441 60.58 µM -1.83405642857212 0.0350909219420956 no 3237 0.0333228091421355 4604 6837235 SGTC_663 1486-0733 13.9 µM -1.84039542748532 0.034589153730036 no 3238 0.0328551021459088 4645 722445 YPR165W RHO1 SGTC_1926 methyl fluorone black 53.6 µM -1.84538115051639 0.0341986586178432 no 3239 0.0324910565806861 4289 72721 Reacts with homocysteine. SGTC_3196 9111891 49.47 µM -1.86484488194602 0.0327087474147887 no 3240 0.0311015750763741 4615 18891510 SGTC_1887 st057648 70.8 µM -1.87363017245842 0.0320540011747532 no 3241 0.0304907081799419 4648 688672 SGTC_94 0334-0113 514.748 µM -1.87781626928361 0.0317458495547026 no 3242 0.0302031519169834 4654 6795178 SGTC_1084 voriconazole 435 nM -1.87822716593288 0.0317157345348083 no 3243 0.0301750476779597 4677 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1026 k007-1105 30.6 µM -1.88006128713352 0.0315815976888111 no 3244 0.0300498628779565 4615 7066794 SGTC_2033 5192550 145 µM -1.88628470003508 0.0311299441410821 no 3245 0.0296282999559724 4648 182073 SGTC_1860 st056228 74.6 µM -1.89370990809899 0.0305980768388276 no 3246 0.0291317627306562 4646 688679 SGTC_92 0063-0024 660.874 µM -1.90266675710857 0.0299665354166969 no 3247 0.0285420211357148 4710 3594437 SGTC_1481 3346-2004 36 µM -1.90445062655094 0.0298420557167786 no 3248 0.0284257605504961 4732 2770522 SGTC_2779 methotrexate 400 µM -1.90663804985544 0.0296900015063799 no 3249 0.0282837371358705 4637 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2753 fluvastatin 17.09 µM -1.9083386841795 0.029572230121874 no 3250 0.0281737281071343 4636 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2193 5925765 200 µM -1.91133257052317 0.0293658413957068 no 3251 0.0279809279886542 4679 877370 SGTC_2260 7964312 200 µM -1.91204113957306 0.0293171703965333 no 3252 0.0279354587638085 4676 231951 SGTC_809 3998-0021 90 µM -1.91768493588296 0.0289318898584109 no 3253 0.0275754864933382 4632 715485 SGTC_2942 9052777 62.25 µM -1.92159344051203 0.0286675449448998 no 3254 0.0273284673093847 4664 6469503 SGTC_2811 7967822 32.47 µM -1.92960043966992 0.0281322752277048 no 3255 0.0268281821545212 4653 2232244 SGTC_717 1532-0246 73.2 µM -1.9371923520177 0.027632465049132 no 3256 0.0263609173989683 4661 9561992 SGTC_3325 9138760 55.175 µM -1.93828483317736 0.0275611548972219 no 3257 0.02629424087951 4618 43844959 SGTC_2009 4012297 12.05 µM -1.95806323345034 0.0262964517512832 no 3258 0.0251112966469147 4616 45595307 SGTC_361 000s-0510 1.45 µM -1.96185543379428 0.0260595928448513 no 3259 0.0248896588353879 4586 660 SGTC_944 3370-0224 231 µM -1.96945421717515 0.0255903447080506 no 3260 0.0244504775220325 4653 4580514 SGTC_105 0111-0055 734.78 µM -1.96989054273121 0.025563616436475 no 3261 0.0244254582727374 4685 5179370 SGTC_993 3909-8757 62.7 µM -1.97047771769436 0.0255276843847302 no 3262 0.0243918231246777 4656 4288324 YLR208W SEC13 SGTC_2431 5490079 200 µM -1.97525613783731 0.0252368395945651 no 3263 0.0241195440587848 4692 5722345 SGTC_1244 0416-0015 52.5 µM -1.97624608577655 0.0251769336188549 no 3264 0.0240634562928584 4646 96201 SGTC_3158 9100007 49.47 µM -1.97931493852517 0.0249919810895748 no 3265 0.0238902793599485 4684 19297233 SGTC_2291 7917025 104.35 µM -1.98969476665775 0.0243748348273996 no 3266 0.023312284774343 4596 2964612 SGTC_2675 theaflavin digallate 100 µM -1.99181497258215 0.024250361692896 no 3267 0.0231956814197687 4638 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1416 3966-0321 25.3 µM -2.00060326592161 0.0237400959451284 no 3268 0.0227175806810008 4728 582530 YLR208W SEC13 SGTC_2214 7179297 48.276 µM -2.00279265719636 0.0236143896101506 no 3269 0.0225997741713232 4740 769744 SGTC_1707 st032323 6.317 µM -2.00869979499845 0.0232780146682908 no 3270 0.0222844902419516 4513 3132057 YMR211W DML1 SGTC_1077 5-fluorocytosine 377 nM -2.00874666875439 0.0232753617108529 no 3271 0.0222820033470621 4710 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1674 st016616 23.6 µM -2.00917759298327 0.0232509842147102 no 3272 0.0222591515595992 4667 625830 SGTC_1965 Pectolinarigenin 58.4 µM -2.01062431416834 0.0231692999568944 no 3273 0.022182576928627 4675 5320438 An anti-inflammatory. SGTC_1327 1436-0082 2.18 µM -2.02044137744743 0.0226213708762646 no 3274 0.0216688125570577 4705 15992205 SGTC_2016 5121758 140 µM -2.02542740365031 0.0223472899866731 no 3275 0.0214117479570916 4606 2795203 SGTC_2055 5235184 200 µM -2.05461826932807 0.0207982853251154 no 3276 0.0199579448325712 4677 2836034 SGTC_1547 harmine 94.2 µM -2.0547837252057 0.0207897713838902 no 3277 0.0199499494201067 4620 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1036 k216-0215 33.5 µM -2.05544152378424 0.0207559519133391 no 3278 0.0199181891434227 4653 622330 SGTC_74 000s-0487 160.283 µM -2.05996172450746 0.0205248120151572 no 3279 0.019701100033778 4611 677548 SGTC_805 3852-0218 479 µM -2.06617732954112 0.0202105418220223 no 3280 0.0194058693228603 4689 6615355 SGTC_1591 genipin 88.4 µM -2.06954216214811 0.0200421197323958 no 3281 0.0192476195629994 4686 442424 A DNA cross-linking agent. SGTC_1781 st038725 66.3 µM -2.0804899363153 0.0195023590192327 no 3282 0.0187403088739419 4680 4270275 YIL048W NEO1 SGTC_727 3032-0951 202 µM -2.0870189610634 0.0191863725770946 no 3283 0.0184432103057266 4732 3652836 SGTC_1120 ficusin 1.78878 µM -2.11543675834982 0.0178612487097438 no 3284 0.0171963698331731 4676 6199 A DNA cross-linker. SGTC_2424 5537928 59.2 µM -2.12719293017028 0.0173363332297774 no 3285 0.0167020281569206 4705 5382802 SGTC_2136 5328288 199.296 µM -2.13683146129954 0.0169158546605483 no 3286 0.0163058511126038 4676 262395 SGTC_2813 7971799 71.43 µM -2.15352471910242 0.016208235985115 no 3287 0.0156387317665993 4683 2234054 SGTC_1962 st076595 64.5 µM -2.16374116763644 0.0157877973327662 no 3288 0.0152421098037674 4687 279619 SGTC_2924 9010168 62.78 µM -2.1638293816345 0.0157842081741885 no 3289 0.0152387231451756 4694 2993929 SGTC_2778 tioconazole 65.09 nM -2.16977213544643 0.015544021859237 no 3290 0.015012056129311 4615 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_667 1498-1044 59 µM -2.18016677243333 0.015131443862865 no 3291 0.0146225508277606 4719 6739982 SGTC_2028 5153890 36.43 µM -2.19745054635255 0.0144662506658733 no 3292 0.0139941423522669 4708 2830968 YPR165W RHO1 SGTC_2152 5568786 200 µM -2.21240893872483 0.0139110278857286 no 3293 0.0134692109097747 4750 5399883 SGTC_2338 7999974 200 µM -2.23831380399158 0.012992905953341 no 3294 0.0126002992785846 4694 315925 SGTC_909 3448-9333 149 µM -2.24469152597098 0.0127750722301377 no 3295 0.012393971214789 4695 3344074 SGTC_3037 9091026 49.47 µM -2.25176327126749 0.0125372346474435 no 3296 0.0121686179390499 4625 25236398 YIL048W NEO1 SGTC_723 4182-0001 115 µM -2.25366977476392 0.0124737747325403 no 3297 0.012108475097184 4720 744821 YLR208W SEC13 SGTC_2485 5633444 17.78 µM -2.27185626492096 0.011882270653499 no 3298 0.0115475965990021 4706 5724239 SGTC_2758 dehydroepiandrosterone 69.35 µM -2.27740397454922 0.0117067474086655 no 3299 0.0113810564907987 4698 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1015 4130-4525 82 µM -2.28184407156486 0.0115678934576867 no 3300 0.0112492738932681 4737 1363237 SGTC_2481 5478948 45.16 µM -2.28453147494092 0.0114845476384692 no 3301 0.0111701574882426 4718 77792 SGTC_147 4466-0538 29.23 µM -2.29375149788091 0.0112025543221158 no 3302 0.0109023884215183 4723 6742687 YHR072W ERG7 SGTC_970 1315-0089 19.5 µM -2.29496988728603 0.0111657440623757 no 3303 0.0108674250375156 4735 6811083 YLR033W RSC58 SGTC_2254 7938975 95.19 µM -2.31070090779226 0.0106998373208046 no 3304 0.0104246905359911 4740 2969277 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -2.3188190836357 0.010466091600593 no 3305 0.0102024240001832 4756 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2355 9061122 103.12 µM -2.32568315628365 0.0102719397438373 no 3306 0.0100177298557634 4744 5302957 SGTC_3243 9134147 49.47 µM -2.33378169971005 0.0100469158899212 no 3307 0.00980357776351573 4786 24282180 SGTC_585 0kpi-0023 191 µM -2.33941531691799 0.00989293018905547 no 3308 0.00965697478996551 4705 64601 SGTC_1817 st052116 64.4 µM -2.35343023423334 0.00951876428151988 no 3309 0.00930054902540723 4756 4361398 SGTC_2147 5545932 89.7195 µM -2.38393219628148 0.00874694342312811 no 3310 0.00856437898504591 4765 797404 SGTC_2317 5986382 200 µM -2.38845019838613 0.00863741485497279 no 3311 0.00845980065015426 4740 877883 SGTC_614 0462-0418 107 µM -2.46388759776435 0.00697834741261585 no 3312 0.00687196023789577 4628 5188303 SGTC_1465 k213-0056 144 µM -2.46941275179652 0.00686870490118171 no 3313 0.00676675082245406 4706 24048857 YMR208W ERG12 SGTC_574 1315-0397 40 µM -2.47791503264386 0.00670295475282893 no 3314 0.00660763058912017 4757 6794277 SGTC_1953 st076800 12.1 µM -2.4989530446067 0.0063079265447573 no 3315 0.00622804070842566 4728 297591 SGTC_1034 k072-0165 12.7 µM -2.50109259897584 0.00626893061921919 no 3316 0.0061905400586168 4762 5835461 SGTC_3223 9129970 49.47 µM -2.50207931894747 0.00625101850392007 no 3317 0.00617331299165381 4764 17248386 SGTC_1782 st039423 80.636 µM -2.50655955226611 0.006170256789927 no 3318 0.00609562595833851 4754 2068169 SGTC_2202 7226349 200 µM -2.51905719543199 0.00594983572771878 no 3319 0.00588347704534933 4785 844334 SGTC_903 1134-0042 114 µM -2.52002799561025 0.00593300959765887 no 3320 0.0058672750421486 4763 701009 SGTC_893 0958-0369 48.9 µM -2.52346175234895 0.00587383301786662 no 3321 0.0058102850489316 4634 6819948 SGTC_3256 9138902 49.47 µM -2.53553994001387 0.00566981845959613 no 3322 0.00561370623352548 4801 17228773 SGTC_3033 9090887 49.47 µM -2.54589200168308 0.00549999289479596 no 3323 0.00544994524511908 4761 19325384 SGTC_3191 9110352 49.47 µM -2.56813156680567 0.00515035588551015 no 3324 0.00511241701284904 4747 17122424 SGTC_3023 9089636 49.47 µM -2.58167667219381 0.00494723282588611 no 3325 0.00491608259305024 4790 17249241 SGTC_1709 st033179 39.1045 µM -2.59420802755228 0.00476570026478615 no 3326 0.00474045511440953 4780 573381 SGTC_2276 7947513 42.08 µM -2.60978083873422 0.00454840000003164 no 3327 0.00453001227745525 4734 2105100 SGTC_1927 st060202 13.8 µM -2.61066377562343 0.00453634892088524 no 3328 0.00451833452964805 4748 688887 SGTC_2153 5569715 200 µM -2.62785714426366 0.00430729293014321 no 3329 0.00429622958020096 4784 2054701 SGTC_711 k292-0785 179 µM -2.63027323715089 0.00427594736378383 no 3330 0.00426581329929147 4731 4146315 SGTC_572 0960-0087 17.7 µM -2.64705175238875 0.0040638369628148 no 3331 0.00405984628804125 4763 6796365 SGTC_3333 9141820 12.094 µM -2.6680087912791 0.00381215782569696 no 3332 0.00381511307631669 4749 1939433 SGTC_1121 fusaric acid 630.51 nM -2.69149135561668 0.0035468231807194 no 3333 0.00355666708787051 4759 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1122 capsaicin 818.572 nM -2.71321166880404 0.00331628884883508 no 3334 0.00333172641319067 4770 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_256 clotrimazole 625 nM -2.72420231568358 0.00320484852154418 no 3335 0.00322285040596746 4756 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_892 0929-0076 29 µM -2.73654483309141 0.00308372670446601 no 3336 0.00310440670019621 4779 5751038 SGTC_1302 1159-0335 255 µM -2.74448224622117 0.00300802772353436 no 3337 0.00303032163034284 4781 649284 SGTC_178 4092-0806 87.505 µM -2.78364541860659 0.00265848294854745 no 3338 0.00268758805161231 4696 2169044 SGTC_3022 9087993 49.47 µM -2.7927962982394 0.00258228930032183 no 3339 0.00261272933091068 4806 17173644 SGTC_679 0422-0091 41.4 µM -2.80638291970002 0.00247279873617224 no 3340 0.0025050557835284 4789 627384 YHR062C RPP1 SGTC_2814 7977482 42.97 µM -2.81103074119016 0.00243631835235233 no 3341 0.00246915336973784 4768 6456762 SGTC_2267 7931562 200 µM -2.81844161793355 0.00237915711361254 no 3342 0.00241286930469633 4762 934880 SGTC_269 exalamide 29 µM -2.83181077969303 0.00227910011254105 no 3343 0.00231426150030072 4789 3316 A derivative of salicylamide. SGTC_3294 9122953 26.2835 µM -2.83574355690271 0.00225040082659599 no 3344 0.00228595700597664 4768 16459826 SGTC_3211 9128781 49.47 µM -2.9536343085126 0.0015283816959401 no 3345 0.00157027957680855 4731 17194361 SGTC_2575 plumbagin 510 nM -3.03780092965329 0.0011498663592651 no 3346 0.00119155663708159 4767 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2286 7945697 125 µM -3.06475151793434 0.00104817863102379 no 3347 0.00108925455206719 4770 1245733 SGTC_145 3737-0113 38.366 µM -3.06653560527225 0.00104174724425686 no 3348 0.00108277507618082 4781 6849351 SGTC_2943 9068529 45.32 µM -3.11033858746747 0.000894764559298972 yes 3349 0.000934364996714658 4768 3270634 SGTC_1609 st001574 46.4 µM -3.13509770076572 0.000820368800945464 yes 3350 0.000858984423692502 4796 3960012 SGTC_3220 9131269 49.47 µM -3.33822487262315 0.000393343629177954 yes 3351 0.000421577415610077 4795 17722206 SGTC_1265 0819-1001 68.8 µM -3.49640942634403 0.00021569668854949 yes 3352 0.000235782275399561 4783 3106768 SGTC_2815 7968870 71.43 µM -3.65633747903053 0.000114555944217594 yes 3353 0.000127922244180952 4790 2977326 YHR190W ERG9 SGTC_2332 7982454 138.89 µM -4.73415348526551 8.2219267431805e-07 yes 3354 1.09985612512494e-06 4804 2981748 SGTC_431 k089-0097 107 µM -5.70488266745765 3.49809216871698e-09 yes 3355 5.82116289634572e-09 4776 5499420 SGTC_430 0958-0115 16.4 µM -7.58637222071485 5.5616557172435e-15 yes 3356 1.6449323536026e-14 4810 6833180