SGTCid condition conc unit NOP56|YLR197W.score NOP56|YLR197W.strain.pval NOP56|YLR197W.strain.significant NOP56|YLR197W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2405 ticlatone 3.52 µM 10.5992025419674 3.08670101588256e-13 yes 1 1.50265936572045e-26 2 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3126 9127922 49.47 µM 10.5990030315492 3.0897730344477e-13 yes 2 1.50586816016686e-26 4 45595682 SGTC_3142 9086498 49.47 µM 9.02132477439765 4.5802327807546e-10 yes 3 9.29141436807725e-20 10 25236367 SGTC_171 k064-0041 9.68 µM 8.72381423914481 1.59959260431883e-09 yes 4 1.34492116536943e-18 3 53325 SGTC_1875 nocodazole 6 µM 8.58358666697794 2.84437004847514e-09 yes 5 4.59799823187948e-18 11 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1597 7-benzyloxygramine 47.5 µM 8.34195835226381 7.51089605395466e-09 yes 6 3.65350953625208e-17 21 260807 SGTC_2694 st077685 81.9 µM 7.52119737959778 1.67095952292943e-07 yes 7 2.71384175661403e-14 2 2838096 SGTC_1623 st003709 20.3 µM 7.13849172964703 6.40216498209818e-07 yes 8 4.71802733734192e-13 1 16192618 SGTC_2021 4019055 173 µM 6.71340829225389 2.63623583804728e-06 yes 9 9.50650659075814e-12 15 44827708 YER133W GLC7 SGTC_1480 1070-0044 41.2 µM 6.29024438308365 9.95823823492449e-06 yes 10 1.58483289167839e-10 2 3124987 SGTC_212 3807-4682 38.772 µM 6.23731526969859 1.1693661423635e-05 yes 11 2.22572144905512e-10 12 3125501 YBL034C STU1 SGTC_625 k213-0058 121 µM 6.15396141178148 1.50220926076975e-05 yes 12 3.77855395825428e-10 3 3655420 SGTC_195 4234-0266 16.654 µM 6.04672750347663 2.06400909537831e-05 yes 13 7.3908725758711e-10 5 2303354 SGTC_2067 5224629 34.075 µM 5.93518610876568 2.85689434824914e-05 yes 14 1.46756180874807e-09 4 2835000 SGTC_2604 4'-hydroxychalcone 11.32 µM 5.83873246321433 3.76753516095221e-05 yes 15 2.62997270388763e-09 3 5282362 SGTC_800 3448-7362 155 µM 5.79494780845165 4.2659628020265e-05 yes 16 3.41712156198448e-09 25 15991913 SGTC_1643 st009866 20.2 µM 5.56354493761682 8.11167628651479e-05 yes 17 1.32174374468579e-08 11 3156273 YOR207C RET1 SGTC_168 3970-0862 530.542 µM 5.53344285170194 8.80370341904108e-05 yes 18 1.57002661619534e-08 20 3135186 SGTC_1060 3448-7350 82 µM 5.49409598551156 9.79217587968889e-05 yes 19 1.96358431872385e-08 9 570178 SGTC_432 NS 1619 61.3 µM 5.45950418610158 0.000107464368036625 yes 20 2.38733039883325e-08 1 4552 A K+/calcium channel activator. SGTC_2134 5324836 1.464 µM 5.35579498136979 0.000141572304134585 yes 21 4.25905263397374e-08 1 699272 SGTC_3127 9126946 49.47 µM 5.31039632282456 0.000159492207745334 yes 22 5.46935489713152e-08 5 27243249 SGTC_76 0433-0009 400.328 µM 5.2997991425932 0.000163970400231804 yes 23 5.79650732143738e-08 2 2841569 SGTC_2601 securinine 100 µM 5.20972736270863 0.000207071797298612 yes 24 9.4559163004604e-08 6 442872 A GABA receptor antagonist. SGTC_1250 0485-0349 40.2 µM 5.18440636291619 0.00022097183275871 yes 25 1.08351992238429e-07 3 6842794 YDL195W SEC31 SGTC_2495 cafestol 54.53 µM 5.11859618856049 0.000261278081328186 yes 26 1.53909117607695e-07 3 16667697 An anti-infammatory. SGTC_928 2764-0428 58.7 µM 5.11849443602952 0.000261345394039563 yes 27 1.53992160950755e-07 11 662578 SGTC_170 4197-0004 226 µM 5.09190103012092 0.000279502629765403 yes 28 1.77245570372349e-07 1 218692 SGTC_2809 7964133 12.99 µM 5.08121674102159 0.000287123080078481 yes 29 1.8751245913523e-07 5 1253665 SGTC_94 0334-0113 514.748 µM 5.06693164353625 0.000297614230194699 yes 30 2.02139688669131e-07 1 6795178 SGTC_2690 usnic acid 100 µM 5.0171567150764 0.000337022226552939 yes 31 2.62208948366552e-07 2 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2409 alverine citrate 63.97 µM 4.9937235866394 0.000357207784095843 yes 32 2.9613073630721e-07 8 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2697 mebhydrolin 72.4 µM 4.95781104527214 0.000390333279590443 yes 33 3.56459241796637e-07 2 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2214 7179297 48.276 µM 4.92491748447558 0.000423154420519995 yes 34 4.21979800678002e-07 2 769744 SGTC_1727 st034309 9.9045 µM 4.88054974310037 0.000471487177739229 yes 35 5.2895262578338e-07 8 870305 SGTC_2151 5563267 85.4165 µM 4.87062867813396 0.00048297237403859 yes 36 5.56218628569888e-07 12 5310824 SGTC_87 0100-0052 35.5 µM 4.829525314717 0.000533371011703403 yes 37 6.84294576740323e-07 11 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_849 0386-0493 241 µM 4.74224941845715 0.00065690901281001 yes 38 1.0567908941023e-06 3 726119 SGTC_65 0798-0905 34.986 µM 4.64156825254077 0.000831953675177815 yes 39 1.72887383660839e-06 5 3602145 SGTC_1999 st074831 12.5 µM 4.63562999009124 0.000843511082584336 yes 40 1.77926006234732e-06 8 17112523 SGTC_3124 9127567 49.47 µM 4.62106646229961 0.000872483547892656 yes 41 1.90886218269159e-06 2 17592030 SGTC_2304 7443016 91.4 µM 4.56112940883659 0.00100161158955462 no 42 2.54396052376855e-06 3 939854 SGTC_584 0986-0246 15.4 µM 4.53937670145619 0.00105265832620577 no 43 2.82103803087782e-06 18 53315 YDR232W HEM1 SGTC_159 3970-0959 50 µM 4.51894193318477 0.00110277487222983 no 44 3.10747176802502e-06 13 6615653 SGTC_2399 5884133 200 µM 4.51644109284138 0.00110905614947366 no 45 3.14438003606575e-06 13 722445 SGTC_2160 5660466 132.927 µM 4.48874514006485 0.00118084491668058 no 46 3.58219739237317e-06 9 2859134 SGTC_3 0833-0587 95.581 µM 4.30671506540563 0.00176871046659365 no 47 8.28484121884314e-06 11 5382644 SGTC_2479 5617353 43.85 µM 4.30648378006557 0.00176960264232357 no 48 8.29350429329892e-06 4 2731746 SGTC_146 3448-8650 53.125 µM 4.23829978411614 0.00205119787317269 no 49 1.1260945325598e-05 11 2891488 YIL048W NEO1 SGTC_534 k292-0788 63.4 µM 4.20355527640441 0.0022098089215932 no 50 1.31377473795007e-05 9 4146317 SGTC_1466 k213-0079 57.5 µM 4.14147790721193 0.0025211042826099 no 51 1.72537557890454e-05 10 3657981 SGTC_3093 9117344 49.47 µM 4.1194166325665 0.00264094540581449 no 52 1.89916408297984e-05 6 24824913 SGTC_530 4358-1714 28 µM 4.10781537380709 0.00270600882671773 no 53 1.99709590202243e-05 3 1564641 SGTC_1516 st013856 110 µM 4.03650036055348 0.00313874572005293 no 54 2.71272211841824e-05 4 5281404 A mutagen and neurotoxin. SGTC_2040 5100729 123 µM 4.01929654053831 0.00325205163858075 no 55 2.91860822908748e-05 5 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_201 4262-0159 12.803 µM 3.99897014966128 0.00339065534655337 no 56 3.18093511806809e-05 11 1341029 SGTC_624 k048-0052 28 µM 3.9826618984967 0.00350567357268726 no 57 3.40738355156093e-05 5 6835531 SGTC_528 3492-0019 172 µM 3.95953050622126 0.00367482441754425 no 58 3.75486258284215e-05 20 2869262 SGTC_1484 3473-2379 286 µM 3.95635814403004 0.00369858487366386 no 59 3.80505218726599e-05 2 671917 SGTC_2458 5808907 16.39 µM 3.95360595880041 0.00371930981325752 no 60 3.8491074697067e-05 4 2731747 SGTC_1136 pergolide 1.05886 µM 3.94482150023029 0.00378615851833431 no 61 3.99297218921459e-05 17 47811 A dopamine receptor agonist. SGTC_532 1548-0774 215 µM 3.91954821879901 0.00398453373822251 no 62 4.43575556994975e-05 5 5932993 SGTC_2334 9017922 200 µM 3.90472706059979 0.00410515102117373 no 63 4.71658940712875e-05 3 3163164 SGTC_1308 1187-1617 41.4 µM 3.90434051109861 0.00410834009129407 no 64 4.72413376237695e-05 9 2882570 SGTC_2270 7924575 90.91 µM 3.89459574386786 0.00418947124479451 no 65 4.91813174244599e-05 4 1262135 SGTC_54 0159-0055 9 µM 3.86480046780525 0.00444649837147251 no 66 5.55900249461427e-05 8 3319099 SGTC_535 2293-4129 48.2 µM 3.84666230461512 0.00460977801127977 no 67 5.9868911141207e-05 9 396118 YIL048W NEO1 SGTC_599 1935-0052 86.5 µM 3.82187500609251 0.00484156122369723 no 68 6.62204097223864e-05 4 9557311 SGTC_1200 1643-0193 18.4 µM 3.78627535471421 0.00519262403493263 no 69 7.64611078918621e-05 6 5403974 SGTC_3013 9080133 71.4286 µM 3.78439147610141 0.00521181742679572 no 70 7.70425620914653e-05 3 17050193 SGTC_1032 k061-1018 98.7 µM 3.77397729774983 0.0053190627981921 no 71 8.0332693915873e-05 6 4005393 SGTC_3233 9132340 49.47 µM 3.75547207445371 0.0055144800981381 no 72 8.65075263600109e-05 12 17682950 SGTC_2299 7976368 114.88 µM 3.72593754309093 0.00583960007425754 no 73 9.72952933996059e-05 9 2979718 SGTC_2907 7721985 69.9 µM 3.71251186381237 0.00599293315383484 no 74 0.000102606219147825 8 3267881 SGTC_1058 3448-5425 97.3 µM 3.70962671359789 0.00602634630677044 no 75 0.000103782526899473 11 7279705 SGTC_2596 sinensetin 100 µM 3.68871852994064 0.00627345957761535 no 76 0.000112693196271561 6 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_37 0566-0070 1.56 µM 3.68252571835072 0.00634835447096401 no 77 0.000115467280906344 5 1626686 SGTC_3075 9116269 49.47 µM 3.66245621919547 0.00659653865389969 no 78 0.000124904228229802 10 17015205 YNL244C SUI1 SGTC_501 nsc-95397 161 µM 3.64649459207047 0.00680000920001947 no 79 0.00013292103504392 10 262093 SGTC_617 3770-0098 35 µM 3.64315976101897 0.00684321347084788 no 80 0.000134655782568256 26 5962639 SGTC_312 4092-0653 6.84 µM 3.62895551466118 0.0070299635172389 no 81 0.00014228513420681 34 1148278 SGTC_2734 clemastine 41.6 µM 3.59414807171955 0.00750673205317235 no 82 0.000162727360192986 3 26987 Clemastine is a selective histamine H1 antagonist. SGTC_942 3253-1115 227 µM 3.57417011422213 0.00779305212365066 no 83 0.000175670230412645 10 46497897 SGTC_1640 st009078 66.4 µM 3.56191227092653 0.00797344742253515 no 84 0.000184081708499618 2 690618 SGTC_1680 diphenhydramine 100 µM 3.56180110577428 0.00797510007075696 no 85 0.000184159686143699 17 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3128 9127691 49.47 µM 3.56041879868961 0.00799567545335196 no 86 0.00018513189904292 4 41316314 SGTC_2051 5263410 176 µM 3.55242392609279 0.00811559566319335 no 87 0.000190849685370008 9 227584 SGTC_1357 1503-1303 39.5 µM 3.53259790622425 0.0084198227162041 no 88 0.000205748911951216 11 292895 SGTC_2305 7443522 69.23 µM 3.52447981402739 0.00854725405158945 no 89 0.000212157571435458 11 5415886 SGTC_407 eburnamonine 100 µM 3.4524727134185 0.00975363656089978 no 90 0.000277736827197379 6 3195 SGTC_2480 5767542 37.17 µM 3.43845892853486 0.0100049836738335 no 91 0.000292517638677128 6 2867358 SGTC_3152 9099253 49.47 µM 3.43759559982323 0.0100206513103133 no 92 0.000293451751157709 34 25236131 SGTC_1103 duloxetine 36.1 µM 3.43476912240341 0.0100720959655027 no 93 0.000296529433853163 12 60835 A selective serotonin reuptake inhibitor. SGTC_2427 5545055 42.75 µM 3.43303170577275 0.0101038328974116 no 94 0.0002984361479476 13 5372858 SGTC_3307 9126885 69.2785 µM 3.43060296876336 0.0101483442248364 no 95 0.000301120677903042 8 24824909 SGTC_2232 chlorophetanol 41.5365 µM 3.42745903534776 0.0102062169048821 no 96 0.00030462910938404 9 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_124 0136-0217 7.121 µM 3.41142617660171 0.0105058440941873 no 97 0.000323119990261489 33 3976905 SGTC_313 3474-0040 5.03 µM 3.40712589430788 0.010587501386205 no 98 0.000328254190367929 12 1043375 YIL048W NEO1 SGTC_3243 9134147 49.47 µM 3.40325334071761 0.0106615091950412 no 99 0.000332942533918901 7 24282180 SGTC_2095 5432005 200 µM 3.39970674118124 0.0107296825908908 no 100 0.000337290805021368 8 783734 SGTC_1197 1601-0112 267 µM 3.37846334994444 0.0111460259081306 no 101 0.000364460739916936 11 7350313 SGTC_2028 5153890 36.43 µM 3.37752582246343 0.0111647195465093 no 102 0.000365705427058423 16 2830968 YPR165W RHO1 SGTC_231 b-estradiol 524 µM 3.37337409947502 0.0112478300056026 no 103 0.000371264972873528 4 450 A steroid. SGTC_2503 beta-caryophyllene alcohol 24.72 µM 3.36739120832554 0.0113685430474613 no 104 0.000379414798247462 5 61125 An anti-inflammatory. SGTC_379 3970-0972 5.9 µM 3.36571409688456 0.0114025824300949 no 105 0.00038172897152605 11 2898042 YBL034C STU1 SGTC_2608 thymoquinone 42.66 µM 3.36186703976758 0.0114809986720717 no 106 0.000387086957126845 7 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1064 honokiol 6.76 µM 3.31716595572429 0.0124270603425819 no 107 0.000454677921552372 16 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_320 4092-0846 5.34 µM 3.31472651022597 0.0124805777893215 no 108 0.000458664129033484 32 1359356 SGTC_682 0kpi-0099 17 µM 3.30544265324871 0.0126860794515389 no 109 0.000474132534955381 51 1714895 YML126C ERG13 SGTC_936 3005-4620 401 µM 3.30273267213981 0.0127466153289828 no 110 0.00047873809280784 7 777207 SGTC_607 4491-0986 66.8 µM 3.29402373839148 0.0129428517102066 no 111 0.000493820785999561 13 698981 YDR232W HEM1 SGTC_224 benfluorex 43.875 µM 3.27340986345685 0.0134177773218527 no 112 0.000531291374567312 10 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1677 st019204 53.9 µM 3.27000229307341 0.0134977169477814 no 113 0.000537733062771541 13 3945625 SGTC_1361 1608-0041 5.61 µM 3.26086117565853 0.0137141960487476 no 114 0.000555372035551635 6 X1361 SGTC_2330 7979373 200 µM 3.25822274921184 0.0137772333994038 no 115 0.000560561836437745 19 1863007 SGTC_490 phenamil 164 µM 3.24002020044513 0.0142189769480994 no 116 0.000597606159780586 8 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_78 0336-0123 156.75 µM 3.20900700492915 0.0149997338615157 no 117 0.000665971235039746 16 6765896 SGTC_650 1328-0195 38 µM 3.20161291798157 0.0151912291440788 no 118 0.000683302507341556 8 2780821 SGTC_2313 7726885 200 µM 3.1966383760824 0.0153212405749828 no 119 0.000695195591883502 15 726423 SGTC_1290 0986-0249 10.2 µM 3.19276016835103 0.0154232607024884 no 120 0.000704599674512067 21 53329 SGTC_284 0988-0104 32.6 µM 3.18942877930294 0.015511361352938 no 121 0.000712771304275051 6 4666532 SGTC_2438 5259590 200 µM 3.18807543832118 0.0155472744813421 no 122 0.00071611582625053 8 1201127 SGTC_1887 st057648 70.8 µM 3.18589544140544 0.0156052743412785 no 123 0.00072153370261521 10 688672 SGTC_3250 9135583 49.47 µM 3.18192962265119 0.0157112630302327 no 124 0.000731486817510651 5 7699353 SGTC_2945 9067681 61.76 µM 3.15712023679929 0.0163884212439589 no 125 0.000796678156479827 12 16456930 SGTC_2909 7941780 10.49 µM 3.14455087018672 0.0167409306144837 no 126 0.000831709941922987 12 1243215 SGTC_3218 9131285 49.47 µM 3.13618947317632 0.0169790028338389 no 127 0.000855792929287638 11 17156417 SGTC_961 1252-1571 372 µM 3.13549331709883 0.0169989542161604 no 128 0.000857826686451238 12 6813498 SGTC_1859 st055998 20 µM 3.12628032466667 0.0172648859972281 no 129 0.000885163559243387 17 676301 SGTC_2174 5790901 200 µM 3.12326022520018 0.0173528306927528 no 130 0.000894297664220878 18 786020 SGTC_1350 1495-0454 146 µM 3.11381348112102 0.0176303921941796 no 131 0.000923431005805769 13 1069057 SGTC_1724 st037281 8.293 µM 3.10850667809703 0.017787970855376 no 132 0.000940176981907392 25 574124 YDL195W SEC31 SGTC_2349 9023730 187.07 µM 3.08919444058819 0.0183716044446099 no 133 0.00100350019626099 8 4126287 SGTC_1394 3474-0001 65.7 µM 3.08312207500162 0.0185584552665739 no 134 0.00102420553740706 9 5017666 YIL048W NEO1 SGTC_2580 diallyl disulphide 81.36 µM 3.08125042582243 0.0186163724106584 no 135 0.00103066600631499 18 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1205 4161-2785 76 µM 3.07165416463261 0.0189157459475567 no 136 0.00106438102595836 9 3498106 SGTC_273 hydroxyurea 18.1 mM 3.06552207340481 0.0191091848840391 no 137 0.00108645168868429 36 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_255 tunicamycin 200.472 nM 3.06295246763044 0.0191907426413712 no 138 0.00109582434474915 22 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2007 4011539 71.82 µM 3.06147242456435 0.0192378524845784 no 139 0.00110125639240791 14 45595301 SGTC_3145 9085516 49.47 µM 3.05438653321171 0.0194647608098284 no 140 0.00112760653117264 27 25236195 SGTC_1019 4262-0212 3.4 µM 3.03193797052824 0.0201986875766096 no 141 0.00121494565662505 25 4677213 SGTC_189 3970-0742 2.116 µM 3.03136420984832 0.0202177493539416 no 142 0.00121725697893257 7 2891807 SGTC_22 0964-0034 14.468 µM 3.02716080238696 0.0203578628646415 no 143 0.00123431298828638 43 138402 SGTC_3028 9087778 49.47 µM 3.02355537642678 0.0204786985662593 no 144 0.00124911651285446 5 17217395 SGTC_2388 9080168 200 µM 3.00687504096377 0.0210456785213942 no 145 0.00131974119432026 6 15943073 SGTC_1992 st073643 23.3 µM 2.9968024645523 0.0213944449053319 no 146 0.00136413718593307 18 3161292 SGTC_3251 9135047 49.47 µM 2.99566367406438 0.0214341816380301 no 147 0.0013692414567159 12 17682963 SGTC_3178 9107506 49.47 µM 2.98968493384486 0.0216438277164331 no 148 0.00139632669131921 20 8897194 SGTC_2461 5755302 26.15 µM 2.98899266368833 0.0216682138977912 no 149 0.00139949426114495 12 2788904 SGTC_2944 9067346 25.62 µM 2.98858337515679 0.0216826425737683 no 150 0.00140137009816977 26 6473075 SGTC_2050 5263056 171 µM 2.98599690274229 0.0217740115167326 no 151 0.0014132775298079 47 763468 YGL055W OLE1 SGTC_2556 citropten 84.59 µM 2.98296764869788 0.0218814353248177 no 152 0.00142734083506799 18 2775 A potential DNA crosslinker. SGTC_1204 4049-0315 18.3 µM 2.96795491497346 0.0224204464023804 no 153 0.00149894149782394 22 588402 SGTC_1080 nisoldipine 24.4 µM 2.94145975436336 0.0233990412943343 no 154 0.00163334644237426 20 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2962 9082311 13.18 µM 2.93166265008445 0.0237698849072305 no 155 0.00168576382400053 25 16459453 SGTC_435 c-PAF 6.7 µM 2.90380921424653 0.0248512930140057 no 156 0.00184326366286241 24 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1767 st044992 70.3 µM 2.90004570619357 0.025000527312546 no 157 0.00186554125081533 11 9600693 SGTC_1141 3253-0389 52.6 µM 2.89748950135413 0.0251023163144355 no 158 0.001880811640291 14 5402031 SGTC_887 0885-0007 9.62 µM 2.88634222857169 0.0255502739460526 no 159 0.00194874050552126 33 5719458 SGTC_2512 diallyl trisulfide 49.23 µM 2.87139977451646 0.0261612249998551 no 160 0.00204329173987337 11 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_53 0973-0023 39.979 µM 2.86736911435975 0.0263281028409633 no 161 0.00206949983324483 26 674768 SGTC_776 4476-4378 112 µM 2.86675406843781 0.026353645119026 no 162 0.00207352568872921 12 2892008 SGTC_756 0508-1999 28.3 µM 2.86313632759526 0.0265043060472266 no 163 0.00209735020002433 28 6753853 SGTC_44 0929-0055 61.211 µM 2.85492546702048 0.026848919287708 no 164 0.00215234649399571 24 1379590 SGTC_3081 9117243 49.47 µM 2.83767414854553 0.0275851606546587 no 165 0.00227217745349371 58 45595589 SGTC_2947 9072639 7.68 µM 2.83275801612403 0.0277980236624003 no 166 0.00230741530546726 23 16488146 SGTC_2971 9092186 9.93 µM 2.82275589929905 0.0282353301608389 no 167 0.00238064038331276 27 25236400 SGTC_2812 7970281 58.44 µM 2.78966342691439 0.0297231830370756 no 168 0.00263814300528524 27 2233435 SGTC_626 0214-0009 33 µM 2.75828453947466 0.0311935167753742 no 169 0.0029052797949087 20 3437874 SGTC_3253 9135987 49.47 µM 2.74463986828694 0.0318513815372124 no 170 0.00302886670592332 17 4182430 SGTC_126 0417-1624 672.48 µM 2.74202118169563 0.0319789407476336 no 171 0.00305312019088431 42 41912 YDL195W SEC31 SGTC_339 3091-4833 71.4 µM 2.73987341989782 0.0320838753017619 no 172 0.00307314252227737 44 3240077 SGTC_1062 mesoridazine 14.2 µM 2.73590182764214 0.0322786667755909 no 173 0.00311047911116668 17 4078 A neuroleptic. SGTC_1689 st020265 53.493 µM 2.72380793778941 0.0328778453553799 no 174 0.00322670116051346 20 5758320 YPR016C TIF6 SGTC_1151 3909-8316 15.3 µM 2.72007666297921 0.0330645473585798 no 175 0.00326333914272863 22 800431 SGTC_888 0916-0002 6.97 µM 2.71579476556611 0.0332798764529953 no 176 0.0033058445196584 15 2802138 YIL048W NEO1 SGTC_1808 st050063 61.5 µM 2.70628316450758 0.0337623319395493 no 177 0.0034020500423261 13 4011993 SGTC_2720 fluspirilene 36.88 µM 2.70465515958863 0.033845482965818 no 178 0.00341876645512833 15 3396 An atypical antipsychotic. SGTC_1545 lovastatin 49.4 µM 2.70277229863819 0.0339418608834525 no 179 0.00343819175076685 29 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_121 0557-0495 61.343 µM 2.69548828107084 0.0343168355337184 no 180 0.00351427750531379 31 3104427 SGTC_706 4262-0057 46.9 µM 2.69041637489396 0.0345799381149432 no 181 0.0035681459058587 22 883298 SGTC_679 0422-0091 41.4 µM 2.6890141545162 0.0346529692529338 no 182 0.00358316902241159 32 627384 YHR062C RPP1 SGTC_2250 alverine citrate 130 µM 2.68681854183584 0.0347675766677088 no 183 0.00360680646444725 57 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1375 2910-0797 186 µM 2.68193350446182 0.0350236844426201 no 184 0.00365990039055426 17 742508 SGTC_3323 9138564 53.9225 µM 2.6751148136211 0.0353837546804745 no 185 0.00373518309100332 25 43912313 YNL103W MET4 SGTC_236 1509-0011 5.31 µM 2.66489712765303 0.0359289913471725 no 186 0.00385059385234214 62 3107280 SGTC_2210 7115885 190.385 µM 2.65734665437996 0.0363363065981933 no 187 0.0039379205803654 20 2927039 SGTC_1806 st050005 60.3 µM 2.64692656053048 0.0369046249278371 no 188 0.00406134954355718 22 5194765 SGTC_1187 1391-0724 117 µM 2.63666871250367 0.0374711723203679 no 189 0.0041862277179628 17 6997986 SGTC_2974 9094440 9.66 µM 2.63546044857707 0.037538370619674 no 190 0.00420116086580191 48 25236134 SGTC_3108 9121785 49.47 µM 2.63279361715839 0.0376870363059922 no 191 0.00423428946475527 34 17140271 SGTC_1590 st077108 57.8 µM 2.63071254361028 0.0378033817966356 no 192 0.0042603035873316 23 5489485 SGTC_77 0828-0286 12.516 µM 2.61734657630088 0.0385576309885741 no 193 0.00443081576418847 31 745345 SGTC_253 dyclonine 31.25 µM 2.61618847453693 0.0386235566261269 no 194 0.00444587306813996 27 3180 An oral anasthetic. SGTC_172 1112-0046 2.638 µM 2.61419214160165 0.038737414677498 no 195 0.00447193614171328 22 2802135 YIL048W NEO1 SGTC_1944 st076371 56.9 µM 2.60993627612214 0.0389810548384356 no 196 0.00452795450589934 20 24208455 SGTC_638 3970-0837 4.09 µM 2.60929275424214 0.0390180036010222 no 197 0.00453647925537851 20 4118451 YLR208W SEC13 SGTC_930 2810-3379 265 µM 2.60505135562163 0.0392622436739496 no 198 0.00459302449999723 25 1015764 SGTC_350 k064-0020 19.8 µM 2.59989672219426 0.0395607455184232 no 199 0.00466259103133507 28 2790705 SGTC_2413 inermin 26.06 µM 2.59980655693561 0.0395659833166498 no 200 0.00466381621576626 46 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3254 9136651 49.47 µM 2.59328974735825 0.039946047997289 no 201 0.00475313221913197 31 16454030 SGTC_258 haloperidol 50.781 µM 2.59084192783999 0.0400895708107681 no 202 0.00478707286047613 48 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_207 4185-0010 4.486 µM 2.58215837234395 0.0406020958310221 no 203 0.00490922583802792 46 3761753 SGTC_3035 9091303 49.47 µM 2.56922538902929 0.0413752793359233 no 204 0.00509630700550702 13 25237002 SGTC_2065 5221596 34.26 µM 2.56677438054632 0.041523146591163 no 205 0.00513246890294694 27 788581 SGTC_1324 1418-0026 34.4 µM 2.5557434655937 0.0421939404321487 no 206 0.00529806026527316 20 1372513 SGTC_1970 st070122 35.8 µM 2.54023831930449 0.04315161077457 no 207 0.00553884780197878 38 102928 SGTC_3351 9150312 21.596 µM 2.52833638723243 0.0438985778970232 no 208 0.00573022441888951 44 4904905 SGTC_210 3551-0445 56.827 µM 2.52280392379731 0.0442493292613748 no 209 0.00582116483133811 35 2865180 YOR207C RET1 SGTC_2457 5731572 11.68 µM 2.51938181349539 0.0444674152523492 no 210 0.00587805497711265 21 2865357 SGTC_287 k060-0039 29.6 µM 2.51003860633485 0.0450672562210179 no 211 0.00603589814981585 36 5861974 SGTC_1298 1079-1278 263 µM 2.50656470538855 0.045291937222041 no 212 0.0060955371045029 26 2840950 SGTC_2769 toremifene 3.73 µM 2.49699392734057 0.0459156086919653 no 213 0.00626255508028076 31 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3180 9109287 49.47 µM 2.49213613037211 0.0462347927186369 no 214 0.00634886802434966 46 18891271 SGTC_2728 chlorpromazine 9.18 µM 2.48884254781445 0.0464522110034897 no 215 0.00640798549064954 13 2726 A thorazine and dopamine antagonist. SGTC_981 1488-1094 54.9 µM 2.48522750159756 0.0466917939129048 no 216 0.00647343327259869 14 3449522 SGTC_2821 7996764 71.43 µM 2.47801667690977 0.0471726434663598 no 217 0.00660574849846671 33 2987135 SGTC_635 k038-0028 24.7 µM 2.47690090218455 0.0472474016319407 no 218 0.00662643466037338 44 4035102 SGTC_1763 st044482 94.5 µM 2.46247346601908 0.0482226333699602 no 219 0.0068991191089906 36 88505 SGTC_3356 9151811 4.48 µM 2.4515676147035 0.0489704565005756 no 220 0.00711177306024154 24 1859254 YPR165W RHO1 SGTC_229 benomyl 22.8748 µM 2.4460694360272 0.0493509687164116 no 221 0.00722115916208269 35 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_145 3737-0113 38.366 µM 2.44256199033811 0.0495949390948565 no 222 0.0072917124083918 106 6849351 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 2.43685680729886 0.0499938344187972 no 223 0.00740777243794894 27 16623 A steroid. SGTC_3236 9132701 49.47 µM 2.43671851744239 0.0500035350429649 no 224 0.00741060574983897 27 24282524 SGTC_3055 9094636 49.47 µM 2.43650410810511 0.0500185781909799 no 225 0.00741500050187709 38 25236176 SGTC_3102 9121669 49.47 µM 2.43375458085051 0.0502118074767565 no 226 0.00747156150890209 24 41905072 SGTC_1090 efavirenz 20.7 µM 2.4267123505827 0.0507094305190017 no 227 0.00761816541796204 32 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_71 0417-1750 47.813 µM 2.41763772645112 0.0513564503793665 no 228 0.00781081048169065 36 6811472 SGTC_1180 1193-0155 285 µM 2.41685111624953 0.0514128435018447 no 229 0.00782770956070946 30 2921347 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 2.41640466704244 0.0514448719366127 no 230 0.00783731511938482 16 364106 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 2.41486374927671 0.0515555398786181 no 231 0.00787054837670457 39 1377 SGTC_2352 9027995 87.8 µM 2.41482043605873 0.0515586533453485 no 232 0.00787148430927473 22 2997347 SGTC_900 1112-0045 141 µM 2.41269920788679 0.0517113157805415 no 233 0.00791744077995243 23 56211 YIL048W NEO1 SGTC_1465 k213-0056 144 µM 2.41082142298966 0.051846757508399 no 234 0.0079583197757038 43 24048857 YMR208W ERG12 SGTC_3033 9090887 49.47 µM 2.40993456474795 0.0519108231684958 no 235 0.00797769094301744 55 19325384 SGTC_952 1185-0122 232 µM 2.40808718254468 0.0520444780110132 no 236 0.00801817549002301 29 678600 SGTC_798 1287-0182 476 µM 2.39890154644101 0.0527131063451213 no 237 0.00822216772515109 29 1649755 SGTC_1773 st048542 73.5835 µM 2.39450577741205 0.0530354795165605 no 238 0.00832139062548857 83 3237138 SGTC_3019 9081971 49.47 µM 2.38503566787682 0.053735301935121 no 239 0.00853873276027908 34 16451803 SGTC_1094 duloxetine 25.4 µM 2.38034532505225 0.0540846068640312 no 240 0.00864821033254841 30 60834 A selective serotonin reuptake inhibitor. SGTC_2629 bisabolol 100 µM 2.37209205526424 0.0547036155091316 no 241 0.00884384163174089 44 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1503 4585-0012 61.3 µM 2.36882977280366 0.0549498311510354 no 242 0.00892223218400362 37 2922052 SGTC_1238 0333-0287 48.8 µM 2.36724067024295 0.0550700829461973 no 243 0.00896063732209297 24 7226 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 2.36227663175069 0.0554470650497297 no 244 0.00908154162450103 27 688761 SGTC_1438 4092-1045 4 µM 2.36008312144967 0.055614293734809 no 245 0.00913542034456446 34 1351342 SGTC_579 4491-1009 110 µM 2.35978409599238 0.0556371216180285 no 246 0.00914278687536436 41 1271041 SGTC_1931 st074438 57.1 µM 2.3566131548148 0.0558796495065484 no 247 0.00922122395134617 56 2787313 SGTC_274 sirtinol 40.1 µM 2.35368830908612 0.0561040936524296 no 248 0.00929409508715204 45 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2589 lobaric acid 100 µM 2.35241855724697 0.0562017517509456 no 249 0.00932588688413574 25 73157 A novel microtubule depolymerizer. SGTC_278 4092-0821 23.9 µM 2.35070554534773 0.0563337138217543 no 250 0.00936892768076929 17 877900 SGTC_1065 prochlorperazine maleate 2.48 µM 2.34266919384826 0.0569560586364838 no 251 0.00957317533624367 37 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1726 st035556 14.5795 µM 2.33834353196492 0.0572932773054897 no 252 0.00968471724514375 24 5919439 SGTC_2655 perillic acid 100 µM 2.33404923616259 0.0576296028585871 no 253 0.00979657197594986 21 5702197 An apoptosis inducer. SGTC_1662 st014054 52 µM 2.33397073873245 0.0576357651292109 no 254 0.00979862707910612 15 2838777 SGTC_1502 4534-4282 27.7 µM 2.32843089558844 0.0580719687649199 no 255 0.0099446173495054 17 3278949 SGTC_2699 st077704 54.6 µM 2.32821852910617 0.0580887418516311 no 256 0.00995025139060426 30 645852 SGTC_2658 polymyxin b sulfate 77.05 µM 2.3159397944382 0.0590650277338155 no 257 0.010280778075399 43 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1862 st057513 3.81 µM 2.31473458325424 0.0591615440066308 no 258 0.010313730955609 39 5393163 SGTC_120 rhodamine 6G 52.259 µM 2.31434895169718 0.0591924524364086 no 259 0.0103242943228538 77 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2958 9077254 16.72 µM 2.31083153177688 0.0594749590548496 no 260 0.0104210810547623 34 16457351 SGTC_1342 1486-1464 234 µM 2.30951234878169 0.059581183234685 no 261 0.0104575836173262 35 3253938 SGTC_2938 9059746 27.26 µM 2.30692027002302 0.0597903374657212 no 262 0.0105296326470173 44 6471769 SGTC_841 0251-0215 91.2 µM 2.30060334287347 0.0603024577704346 no 263 0.0107070309593153 30 3888614 SGTC_2497 7-hydroxyflavone 100 µM 2.29951770077906 0.0603908166918427 no 264 0.0107377797097904 32 5281894 SGTC_1624 st003710 6.25 µM 2.29783401457151 0.0605280499738462 no 265 0.0107856190091169 24 24207033 SGTC_2838 9002687 71.43 µM 2.2965788978985 0.0606305102058584 no 266 0.0108214017904746 57 6457060 SGTC_1993 st073995 70.8 µM 2.29369527150458 0.0608664261540254 no 267 0.0109040042760864 33 3098394 SGTC_851 0394-0702 453 µM 2.29299055767918 0.0609241893703855 no 268 0.01092427428686 62 762646 SGTC_1126 isoteolin 1.0172 µM 2.2892031071218 0.0612353694490719 no 269 0.0110337770797032 35 133323 SGTC_2943 9068529 45.32 µM 2.28917468517729 0.0612377093056635 no 270 0.0110346024114193 52 3270634 SGTC_792 4534-1957 155 µM 2.28721149348161 0.0613994995811566 no 271 0.0110917407422211 27 1717904 SGTC_358 0075-0058 9.45 µM 2.28238698239874 0.061798515064102 no 272 0.0112332516017014 38 1069125 SGTC_3242 9133940 49.47 µM 2.27241632038496 0.0626295594316177 no 273 0.0115306884503131 32 17248444 SGTC_118 0083-0097 135.343 µM 2.27234337084542 0.0626356716415866 no 274 0.0115328895879826 73 5207356 SGTC_2757 clomiphene 4.22 µM 2.270368478143 0.0628013183574387 no 275 0.0115926176895565 58 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_245 methotrexate 289.6 µM 2.26495535728412 0.0632571012397747 no 276 0.0117577095933787 46 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2868 9035608 32.47 µM 2.2598297802891 0.06369104297361 no 277 0.011915908681213 20 6462614 SGTC_2106 5357045 167.29 µM 2.25945451071083 0.0637229048214817 no 278 0.011927563442855 30 668842 SGTC_464 bw-b 70c 158 µM 2.25742796701405 0.0638951806002477 no 279 0.0119906729081077 40 5353454 SGTC_832 4083-0019 164 µM 2.25722758485585 0.0639122346779006 no 280 0.0119969287983829 76 1990758 SGTC_814 3342-0569 96 µM 2.25675848321143 0.0639521727140615 no 281 0.0120115851265251 37 4346283 SGTC_3104 9120930 49.47 µM 2.25252492544309 0.0643134847226932 no 282 0.0121445596965765 38 17014836 SGTC_1748 st037455 53.6035 µM 2.24619760754044 0.0648564429201874 no 283 0.0123456767106855 37 580690 SGTC_2549 cedrol 20.94 µM 2.24589808854749 0.0648822331198851 no 284 0.0123552681776478 53 6708665 A sedative which affects the nervous system. SGTC_1243 0416-0003 5.65 µM 2.24174167045083 0.0652409455177184 no 285 0.0124890365170188 49 2141977 SGTC_95 0471-0001 561.058 µM 2.23976188091237 0.0654123479031201 no 286 0.0125531929064614 31 4015405 SGTC_980 1473-0395 201 µM 2.23297013058029 0.0660030061430917 no 287 0.0127754570854149 37 768876 SGTC_2635 hydroquinidine 100 µM 2.22696107113641 0.0665290341906269 no 288 0.0129749378213937 25 442912 An experimental heart treatment. SGTC_3276 9139060 49.47 µM 2.22336359511067 0.0668455037515371 no 289 0.0130956462151208 39 4870619 SGTC_1439 4092-1168 46 µM 2.21848813296377 0.0672762548594111 no 290 0.0132607839187284 27 2886240 SGTC_3169 9102970 49.47 µM 2.21321647537048 0.0677444213688308 no 291 0.0134413623856815 22 17027839 SGTC_1940 st075990 51.1 µM 2.20274032799534 0.0686822545095092 no 292 0.0138065280588354 37 1084979 SGTC_1029 k015-0030 64.7 µM 2.20181149500399 0.0687658852197232 no 293 0.0138393133823085 40 2208316 SGTC_998 3996-0085 177 µM 2.20100882331118 0.0688382197854939 no 294 0.0138676996076744 39 715391 SGTC_2146 5545642 200 µM 2.19040049186161 0.0697997328897165 no 295 0.0142476021945253 35 825326 SGTC_707 0865-0008 204 µM 2.18999320276131 0.0698368535827168 no 296 0.0142623648930817 40 723043 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 2.18999026761412 0.0698371211497877 no 297 0.014262471328931 48 5106787 A p450 inhibitor. SGTC_663 1486-0733 13.9 µM 2.18902639554016 0.0699250300945382 no 298 0.0142974607873844 37 722445 YPR165W RHO1 SGTC_2272 7805186 180 µM 2.18371611016661 0.0704108767124908 no 299 0.0144915576131055 34 2956062 YPR165W RHO1 SGTC_2292 7671323 168.05 µM 2.18359681527562 0.0704218209274483 no 300 0.0144959438962257 71 937504 SGTC_2912 7964298 10.93 µM 2.18194602955568 0.0705733997152709 no 301 0.0145567580771358 73 2975850 SGTC_1674 st016616 23.6 µM 2.1809797766101 0.0706622394728407 no 302 0.0145924561627328 42 625830 SGTC_1594 piperine 70.1 µM 2.17920950386876 0.0708252257971704 no 303 0.0146580541190316 22 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2255 7941087 197.44 µM 2.17444340063561 0.0712654692715548 no 304 0.0148359258399437 43 935561 SGTC_1520 flindersine 88 µM 2.17266205310768 0.0714305500507131 no 305 0.0149028808984664 47 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3274 9138298 49.47 µM 2.16991944516785 0.0716852861656628 no 306 0.0150064744850021 43 17015756 SGTC_26 0302-0163 425.158 µM 2.16932987463581 0.0717401369513569 no 307 0.0150288243503897 57 3100915 SGTC_2381 9035592 200 µM 2.16824916391148 0.0718407646244879 no 308 0.0150698670032385 36 4749657 SGTC_2090 5301565 104.445 µM 2.16727971589853 0.0719311244227541 no 309 0.0151067661020723 50 2056344 SGTC_1122 capsaicin 818.572 nM 2.15912964256447 0.072694221507411 no 310 0.0154200552665752 41 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3029 9088683 49.47 µM 2.15747531689575 0.0728498713456314 no 311 0.0154843241663737 40 25236615 SGTC_1349 flufenamic acid 69 µM 2.15664783061584 0.0729278223631889 no 312 0.0155165573600625 38 3371 A non-steroidal anti-inflammatory. SGTC_1093 fluphenazine 7.97 µM 2.15211645960634 0.073355819984941 no 313 0.0156940915469194 37 6602611 An atypical antipsychotic. SGTC_3091 9116372 49.47 µM 2.1518652167515 0.0733796065037122 no 314 0.0157039857517298 42 17169793 SGTC_630 4356-0227 183 µM 2.14901069320822 0.0736502741096461 no 315 0.0158167761508611 67 779312 SGTC_218 alverine citrate 93.75 µM 2.14667717497012 0.0738721061556119 no 316 0.0159094955654373 45 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_893 0958-0369 48.9 µM 2.14253259963856 0.074267361649347 no 317 0.0160753241432064 42 6819948 SGTC_2419 paclitaxel 166.5 µM 2.13144150042528 0.0753330291435843 no 318 0.0165263935012035 49 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.13138147606205 0.0753388280173041 no 319 0.0165288638380955 75 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1735 st034310 56.75 µM 2.12627470160208 0.0758334336268281 no 320 0.0167401966189518 52 871153 SGTC_3275 9138069 49.47 µM 2.12208869716844 0.0762407012435052 no 321 0.0169151451893351 44 17617007 SGTC_2009 4012297 12.05 µM 2.12203750079501 0.0762456925599278 no 322 0.0169172945152549 53 45595307 SGTC_560 2332-1943 155 µM 2.11434192456173 0.0769987933770431 no 323 0.0172430370076705 38 21177716 SGTC_2374 9071832 200 µM 2.11276513568915 0.0771537958802022 no 324 0.0173104375633554 42 17381698 SGTC_1447 4239-0816 81.9 µM 2.112539832176 0.0771759631551082 no 325 0.0173200866151964 53 1341554 SGTC_1898 st060199 18.6 µM 2.10785631801822 0.0776378636873158 no 326 0.0175217098255213 46 688866 SGTC_1260 0700-1617 7.75 µM 2.10069938850196 0.0783477488859577 no 327 0.017833681523003 49 2853078 SGTC_1789 tunicamycin 25 nM 2.0985812848054 0.0785587814555817 no 328 0.0179269137846611 60 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_48 0382-0018 55 µM 2.09816668277956 0.0786001397863576 no 329 0.0179452118235483 22 762596 SGTC_2414 st077232 92.9 µM 2.09706198997973 0.0787104181977284 no 330 0.0179940440881217 44 729801 SGTC_1539 benzyladenosine 56 µM 2.09649492726534 0.0787670720133658 no 331 0.0180191547232083 42 92208 A nucleotide analog. SGTC_543 3844-1095 191 µM 2.09045330508116 0.0793725949686871 no 332 0.0182885493994482 50 4230703 SGTC_3346 9158254 43.5805 µM 2.0838713985402 0.0800362710752524 no 333 0.0185859333045332 70 17639500 SGTC_3068 9116768 49.47 µM 2.07071978243344 0.081374948033326 no 334 0.0191924952148226 41 41904888 SGTC_2553 4-methylesculetin 85.09 µM 2.07013598642531 0.0814347606056154 no 335 0.0192198058808217 40 5319502 SGTC_1363 1636-0063 10.4 µM 2.06985208195871 0.081463859897874 no 336 0.0192330992004225 52 6072185 SGTC_2088 5278280 127.392 µM 2.06544409628634 0.0819166708598714 no 337 0.0194404999497172 40 791502 SGTC_1092 toremifene 6.32 µM 2.06531938317442 0.0819295095668077 no 338 0.0194463953745521 44 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2732 terfenadine 20 µM 2.05696690319665 0.0827928190219558 no 339 0.0198447048014547 40 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2296 7971656 126.45 µM 2.04756538326944 0.0837727252045175 no 340 0.0203013020844369 40 666570 SGTC_654 1124-0271 80.9 µM 2.0415333786243 0.0844060039865191 no 341 0.0205989198157723 58 5403748 SGTC_92 0063-0024 660.874 µM 2.0350078809234 0.0850951303821714 no 342 0.0209250400039877 39 3594437 SGTC_2940 9060638 45.86 µM 2.03479314652096 0.0851178788964223 no 343 0.020935845483302 45 4027022 SGTC_2391 6285546 200 µM 2.03142293207881 0.0854755096789061 no 344 0.0211060550552647 51 846083 SGTC_418 lividomycin a 100 µM 2.02566216165443 0.0860894186373359 no 345 0.0213997083614524 40 72394 An antibiotic. SGTC_782 0083-0095 30.5 µM 2.0209391703049 0.0865951905023873 no 346 0.0216430312177186 46 3591729 An indicator and reagent. SGTC_1071 trifluoperazine 6.31 µM 2.01633500543459 0.0870903723127002 no 347 0.0218824784135642 48 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_913 3487-1245 167 µM 2.01595141126803 0.0871317234288201 no 348 0.0219025284285886 63 4016153 SGTC_926 2268-1401 59.4 µM 2.00707808954783 0.0880923565601005 no 349 0.0223706744033686 54 2931578 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 2.00382021634198 0.0884470312535727 no 350 0.0225446612185039 48 5355888 SGTC_496 calpeptin 138 µM 2.00191023329382 0.0886554593966314 no 351 0.0226471934308341 40 73364 A calpain inhibitor. SGTC_2729 fluphenazine 10.66 µM 2.00176164138619 0.0886716899095813 no 352 0.0226551866340532 58 3372 An atypical antipsychotic. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 2.00156011229176 0.0886937062229084 no 353 0.0226660312865288 52 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3150 9097574 49.47 µM 1.99572743602332 0.0893326699549718 no 354 0.0229817995082275 40 17217476 SGTC_711 k292-0785 179 µM 1.9916483604503 0.0897815591805547 no 355 0.0232048266504087 59 4146315 SGTC_455 paf C-16 10 µM 1.99000733441143 0.0899626210506506 no 356 0.0232950637818286 54 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2592 piperlongumine 83.33 µM 1.98934510542523 0.0900357645830921 no 357 0.0233315621366993 53 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_271 rotenone 740 µM 1.98655574452412 0.090344336001176 no 358 0.0234858248004953 38 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2987 9018338 71.43 µM 1.98517992540801 0.0904968240930767 no 359 0.023562228469873 64 5055682 SGTC_2705 st078069 42.8 µM 1.98341807671972 0.0906923764649978 no 360 0.0236603747982498 49 1530061 SGTC_1177 0983-0204 23.6 µM 1.9826350304098 0.0907793895008308 no 361 0.0237041057541399 64 766818 SGTC_1670 st016595 4.04 µM 1.98115953420287 0.0909435167110299 no 362 0.0237866928081611 42 597879 SGTC_190 3970-0790 3.722 µM 1.98106562651684 0.0909539700035719 no 363 0.0237919572239388 39 2832352 SGTC_1081 sertraline 6 µM 1.98094621842473 0.0909672631497768 no 364 0.0237986525937056 50 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2015 5119600 184 µM 1.97452284299929 0.091684473324492 no 365 0.0241611613251409 69 2828786 SGTC_589 1227-0070 34.1 µM 1.96890879203084 0.0923147409885625 no 366 0.0244817828772235 56 2841384 SGTC_3294 9122953 26.2835 µM 1.96785826021516 0.0924330354166595 no 367 0.0245421742676445 57 16459826 SGTC_1925 st057770 10.1 µM 1.95990972004507 0.0933317123221621 no 368 0.0250031716608559 57 5989122 SGTC_774 k060-0086 136 µM 1.95686546117597 0.0936776061045942 no 369 0.0251816441276869 56 5911235 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.9558180157365 0.0937968371918721 no 370 0.0252432979150638 54 15053 SGTC_2798 7813637 45.45 µM 1.94565525422958 0.0949594888924604 no 371 0.0258480824874271 76 956368 SGTC_3201 9113999 49.47 µM 1.93324914955521 0.0963931341257397 no 372 0.0266027563584579 58 16649224 SGTC_318 1488-0629 67.2 µM 1.93067810048533 0.0966922230745227 no 373 0.0267614363890112 46 3662576 SGTC_2546 rhodinyl acetate 100 µM 1.92882618220496 0.0969080777774999 no 374 0.0268762221544425 63 6708682 SGTC_1294 1000-1494 117 µM 1.92720220419116 0.0970976553319463 no 375 0.026977217697036 53 712797 YDL207W GLE1 SGTC_1222 0366-0074 1.18 µM 1.92272808546216 0.0976213561226546 no 376 0.0272571038707922 51 286520 SGTC_2887 9044784 58.44 µM 1.92104843271505 0.0978184952200495 no 377 0.0273628009115755 85 6465546 SGTC_3082 9117008 49.47 µM 1.91537011195182 0.0984871145481749 no 378 0.0277226599835789 40 41448529 SGTC_2581 avocatin a 64 µM 1.91493929919523 0.0985379787613702 no 379 0.0277501226163004 55 6710728 A skin care supplement. SGTC_2889 9059656 51.95 µM 1.91345188291151 0.0987137394396239 no 380 0.0278451139048545 57 3949838 SGTC_1741 st038134 10.228 µM 1.91083337936633 0.0990237124557603 no 381 0.02801299832585 52 1272587 SGTC_1870 st057514 26.5 µM 1.90983118413592 0.0991425384544763 no 382 0.0280774763830653 51 5393161 SGTC_895 0964-0006 13.7 µM 1.90646764961588 0.0995421005894227 no 383 0.0282947795049219 85 6738897 SGTC_1772 st048439 82.2 µM 1.90152758473644 0.10013107404687 no 384 0.0286164714568764 58 2927068 YDL195W SEC31 SGTC_1804 st050076 49.1 µM 1.89976163322083 0.100342233645544 no 385 0.0287322039886154 64 3895976 SGTC_1714 st033236 13.627 µM 1.89705388118309 0.100666637754657 no 386 0.028910413576787 52 2916566 SGTC_1885 st057546 99.9 µM 1.89441038644501 0.100984080780669 no 387 0.0290852794332699 52 702008 SGTC_1661 st013063 9.66 µM 1.89074070932787 0.101425961242725 no 388 0.0293294826591171 60 721395 SGTC_1911 st060208 74.3 µM 1.88908285385332 0.101626051457655 no 389 0.0294403637810207 60 688783 SGTC_1559 coumarin 343 70.1 µM 1.88875852507409 0.10166522900195 no 390 0.0294620962746864 43 108770 A hepatotoxic, DNA x-linker. SGTC_616 4092-0450 108 µM 1.8860504197276 0.101992785999873 no 391 0.0296440803097467 46 787165 SGTC_2702 st077768 96.8 µM 1.88601236299751 0.101997394590791 no 392 0.0296466443447891 46 6484119 SGTC_2565 isoliquiritigenin 100 µM 1.87946697631804 0.102792283164233 no 393 0.0300903792989885 68 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1864 st057645 30.4 µM 1.87932545235391 0.102809519776673 no 394 0.030100034198078 53 688666 SGTC_1102 cgs 12066b 26.1 µM 1.87825969102079 0.102939389392525 no 395 0.0301728239745557 59 6438352 A 5-HT1B full agonist. SGTC_2031 5180455 200 µM 1.87182101442859 0.103726517557489 no 396 0.0306156849741429 45 29949 SGTC_3212 9128307 49.47 µM 1.86776918763679 0.104224086626388 no 397 0.0308971250167756 63 27243542 SGTC_406 estrone 100 µM 1.86170386145263 0.104972145501018 no 398 0.031322422001445 52 5870 A steroid. SGTC_1431 4049-0260 9.09 µM 1.86096591455299 0.105063423730763 no 399 0.0313744951592319 65 3854841 SGTC_408 cantharidin 100 µM 1.86061105641729 0.105107337340914 no 400 0.0313995611675422 59 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1964 st076914 61 µM 1.86045609815822 0.105126517555043 no 401 0.031410512100535 71 24208661 SGTC_2832 7992762 51.95 µM 1.85065528466416 0.106344780744104 no 402 0.0321095804041238 66 2985177 SGTC_2726 cimetidine 79.27 µM 1.84781772072682 0.106699392096496 no 403 0.0323143582374596 46 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_675 1309-0189 238 µM 1.84525339984726 0.107020589550391 no 404 0.0325003429161273 64 4246530 SGTC_2597 laccaic acid a 100 µM 1.8445516025243 0.107108615544472 no 405 0.0325513963876797 69 5491415 A textile dye. SGTC_2279 7948423 32.93 µM 1.8432849205262 0.107267626816827 no 406 0.0326437108216562 58 1247112 SGTC_3273 9137859 49.47 µM 1.84319964163699 0.107278338302698 no 407 0.0326499336053714 70 2377234 SGTC_2383 9036125 200 µM 1.83825570542577 0.107900642078818 no 408 0.0330123673962799 53 79580 SGTC_3320 9137005 35.139 µM 1.83699051709393 0.108060310976626 no 409 0.0331056476595357 77 4908713 SGTC_2001 4023502 57.655 µM 1.8356501357507 0.108229654860909 no 410 0.0332047085692622 60 108941 YCR052W RSC6 SGTC_1046 2001-0062 216 µM 1.83535586260191 0.108266858911019 no 411 0.033226489487121 67 739778 SGTC_2467 5474540 200 µM 1.83392044525887 0.108448466267357 no 412 0.0333329020890713 74 5413519 SGTC_1697 st025554 27.742 µM 1.83220480200797 0.1086658148906 no 413 0.0334604568573965 50 1269519 SGTC_2359 9039622 200 µM 1.82986907796024 0.108962222645638 no 414 0.033634759143879 54 6463596 SGTC_2234 tolnaftate 200 µM 1.82981753704265 0.108968769831925 no 415 0.033638613770747 29 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1751 st044839 27.194 µM 1.82830049922104 0.109161604154965 no 416 0.0337522324765719 48 5291326 SGTC_795 0685-0265 78 µM 1.8240684781945 0.109700842375262 no 417 0.0340708601514862 90 302754 SGTC_859 0439-0102 54.6 µM 1.82284479160359 0.109857118626449 no 418 0.0341634507806205 84 610143 SGTC_1550 gossypolone 36.6 µM 1.81840731005188 0.110425166747221 no 419 0.0345009509573152 63 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_721 1187-1332 279 µM 1.81733083180492 0.110563285050562 no 420 0.0345832358649022 60 25730 SGTC_1933 st074711 15.9 µM 1.81672704749273 0.110640808208891 no 421 0.0346294590471794 78 17250958 SGTC_972 1319-0219 195 µM 1.81340407232224 0.11106816033649 no 422 0.034884760962227 83 23903702 SGTC_1631 benzylvanillin 81.9 µM 1.81258447757796 0.111173746041741 no 423 0.0349479668472393 68 75506 SGTC_2206 7254556 146.969 µM 1.80947908822547 0.111574455176008 no 424 0.0351883030301574 43 4398905 SGTC_541 4513-1321 94 µM 1.80628131445536 0.111988164183861 no 425 0.0354372045142478 83 747515 SGTC_140 0062-0056 502.533 µM 1.8057332217183 0.112059183135021 no 426 0.0354800103682828 57 3758964 SGTC_295 k015-0027 31 µM 1.80135401443001 0.112627774134979 no 427 0.0358235496554783 54 3887424 SGTC_2582 agaric acid 100 µM 1.79639428115978 0.113274224718365 no 428 0.0362159163708362 97 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1847 st056231 15 µM 1.79544670447162 0.113398032221479 no 429 0.0362912784494881 68 5393180 SGTC_375 3970-0961 9.27 µM 1.79043926546139 0.114053891683553 no 430 0.0366916613716918 71 2898222 SGTC_31 0508-1974 57.237 µM 1.78692622462274 0.114515629351335 no 431 0.0369747066542207 48 6810525 SGTC_2132 5317594 122.667 µM 1.78525543736124 0.11473569608667 no 432 0.0371099467521104 59 794577 SGTC_1257 0669-0121 16 µM 1.78474822116973 0.114802563261866 no 433 0.0371510827274455 69 4307855 SGTC_1588 farnesol 29.9 µM 1.77913721069385 0.11554412254401 no 434 0.0376086347101856 63 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_701 4424-0219 185 µM 1.77877727492724 0.115591808069326 no 435 0.0376381421560024 59 2911779 SGTC_1456 k015-0012 13 µM 1.77167030432425 0.116536228611372 no 436 0.038224650913266 80 2989616 SGTC_1839 st053978 48 µM 1.77059352499299 0.116679794090405 no 437 0.0383141597365478 50 3788398 SGTC_1382 3002-2117 298 µM 1.76667364983458 0.117203484627848 no 438 0.0386414493774699 61 1497314 SGTC_1477 0139-0234 16 µM 1.75946201664793 0.11817129494839 no 439 0.0392495331552416 69 620880 SGTC_2606 farnesol 9.78 µM 1.75744068719981 0.118443571082432 no 440 0.0394213616680619 91 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_18 0111-0177 500 nM 1.75532007201387 0.118729697462806 no 441 0.0396022875302405 74 721752 SGTC_2920 7982904 15.77 µM 1.75342805306416 0.118985392124686 no 442 0.0397642795974716 76 6456808 SGTC_1622 st003707 19.4 µM 1.74370893167562 0.120305000019994 no 443 0.0406049285699092 69 10140899 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.74036900743824 0.120760847598664 no 444 0.0408971219749613 101 6708760 SGTC_156 3474-0145 5.642 µM 1.73647010064877 0.12129452395407 no 445 0.0412403733179037 62 2265471 SGTC_2634 4'-methoxyflavone 100 µM 1.73571069394291 0.121398663054633 no 446 0.0413075008355948 65 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2356 9061756 188.97 µM 1.73453487548304 0.121560029598575 no 447 0.0414116116431587 55 20104043 SGTC_2906 7926292 26.41 µM 1.73091425940739 0.122057861024682 no 448 0.0417335289894772 58 2966319 SGTC_50 0929-0078 56.389 µM 1.73016302874479 0.122161333657421 no 449 0.0418005758817737 53 1377751 SGTC_3335 9143315 29.6265 µM 1.72940934879944 0.122265205521797 no 450 0.0418679289990651 59 4899691 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.72357535195956 0.123071342211942 no 451 0.0423922656630913 79 688798 SGTC_2400 5203494 178.7 µM 1.72347271346091 0.123085557983597 no 452 0.0424015377364227 93 6777674 SGTC_1061 3448-9325 110 µM 1.72173796603242 0.123326000377547 no 453 0.0425584982460456 84 723482 SGTC_349 k015-0014 24 µM 1.72103032871637 0.123424175959019 no 454 0.0426226602703105 76 2196908 SGTC_3344 9148862 3.898 µM 1.71557429871577 0.12418296851274 no 455 0.0431199929441971 62 4905352 SGTC_1379 2144-0755 36.5 µM 1.71325509084476 0.124506496691406 no 456 0.0433328102333128 73 5392327 SGTC_2317 5986382 200 µM 1.71164835789396 0.124730980286645 no 457 0.0434807454412543 74 877883 SGTC_2772 vinpocetine 57.06 µM 1.71154976019775 0.124744765001896 no 458 0.0434898367938217 64 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2927 9011802 47.9 µM 1.71088396396074 0.12483787629737 no 459 0.0435512677328473 63 43912568 SGTC_2110 5483698 200 µM 1.70856256672558 0.125162902412617 no 460 0.0437660037864971 69 2848765 YHR062C RPP1 SGTC_1115 galangin 695.678 nM 1.70749301442224 0.125312852472461 no 461 0.0438652275486372 75 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1905 st060207 84.5 µM 1.70567777151797 0.125567634503736 no 462 0.044034045250735 82 1948547 SGTC_840 0245-0196 390 µM 1.70533291168234 0.125616078823219 no 463 0.0440661763794487 74 3827528 SGTC_1316 1272-0050 65.9 µM 1.70531659286282 0.125618371538838 no 464 0.0440676972976389 72 7340392 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.70492826267236 0.125672938676513 no 465 0.0441039022608968 76 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1744 st037937 38.9 µM 1.70246464556108 0.126019504927468 no 466 0.0443341502780736 73 1016152 SGTC_1271 0832-2808 169 µM 1.70229775996101 0.126043005425228 no 467 0.0443497822630989 86 3663794 SGTC_1966 st070145 16.1 µM 1.70171143866175 0.126125594246604 no 468 0.0444047375339716 85 3748532 SGTC_2487 5918373 44.05 µM 1.70046807872541 0.126300857887624 no 469 0.0445214578982856 97 2876279 SGTC_1427 4048-4900 550 nM 1.69730830992481 0.126747021424318 no 470 0.0448191934977664 78 24132586 SGTC_853 0419-0306 21 µM 1.68446283646273 0.128572113164467 no 471 0.0460461279303032 98 762713 SGTC_735 3076-0345 636 µM 1.68437831840396 0.128584181623726 no 472 0.0460542891232372 69 2888990 SGTC_1276 0871-0068 94.2 µM 1.67866580478722 0.129401702734603 no 473 0.0466085969346522 92 3414906 SGTC_831 k061-1017 217 µM 1.67038317702135 0.130593419795268 no 474 0.0474217879621963 99 1240153 SGTC_1078 idebenone 36.1 µM 1.66619792525863 0.131198477488208 no 475 0.047836999544096 102 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2426 5582046 32.21 µM 1.6639610368726 0.131522654968171 no 476 0.0480601080134715 74 2251934 SGTC_2673 kobusone 100 µM 1.66285826247591 0.131682676102464 no 477 0.0481704053950904 59 6710676 An epoxy ketone and protein crosslinker. SGTC_2993 9054257 71.4286 µM 1.65745348243755 0.132468894215879 no 478 0.0487139130968413 110 6470217 YGL055W OLE1 SGTC_392 N-ethylmaleimide 8.33 µM 1.65719347960768 0.132506797467578 no 479 0.0487401821990194 92 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1777 st045864 34.765 µM 1.65705371547811 0.132527175391224 no 480 0.048754307793629 94 4691462 SGTC_623 k072-0108 16.9 µM 1.64850097059937 0.133778295190285 no 481 0.0496249558447868 96 5382803 SGTC_989 1501-0895 10.3 µM 1.6472744934694 0.13395837119115 no 482 0.049750819069924 67 2830112 SGTC_2189 6047310 154.431 µM 1.64720947789012 0.13396792167065 no 483 0.0497574981836958 68 711535 SGTC_996 3970-0799 1.8 µM 1.64630073197547 0.134101461101093 no 484 0.0498509294336437 108 6615648 YGL040C HEM2 SGTC_1152 3909-8331 15.9 µM 1.64234282132464 0.134684138975724 no 485 0.0502594887372705 68 16001939 SGTC_1154 4088-0362 150 µM 1.64060591054541 0.134940392206108 no 486 0.0504396236405478 79 6618304 SGTC_2242 6630449 61.2675 µM 1.63436352930541 0.135864114802124 no 487 0.0510912706965778 67 691249 YDR170C SEC7 SGTC_1146 3579-1023 7 µM 1.63387557327519 0.135936502606647 no 488 0.0511424898436918 92 X1146 SGTC_2005 4024620 188 µM 1.63107768899743 0.136352075788913 no 489 0.051436963877779 79 236743 SGTC_752 1896-0090 130 µM 1.6298856277653 0.136529397882215 no 490 0.0515628358832908 85 772567 SGTC_2790 5423970 71.43 µM 1.62969401477239 0.136557915501123 no 491 0.0515830914917161 95 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1002 4049-0206 172 µM 1.62798359948802 0.136812655809988 no 492 0.0517641816854119 92 4662749 SGTC_2850 9015429 58.44 µM 1.61681430353768 0.138484137174896 no 493 0.0529591854702491 91 6457570 SGTC_897 1000-0139 31.4 µM 1.61504085441453 0.138750808002478 no 494 0.0531509239375986 77 6151020 SGTC_2006 4011487 200 µM 1.61323543703 0.139022644897699 no 495 0.0533466836186993 110 45595294 SGTC_661 1304-0007 33.6 µM 1.61205780580548 0.139200152943831 no 496 0.0534746806741686 89 3117130 SGTC_420 mitomycin C 81.9 mM 1.6097393589558 0.139550070283885 no 497 0.0537273843301063 100 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2498 4'-Methoxychalcone 54.63 µM 1.60943636692263 0.139595844267236 no 498 0.0537604793045249 69 641818 YHR062C RPP1 SGTC_254 nsc-64875 3.808 µM 1.60773406775848 0.139853205906503 no 499 0.0539467169502843 60 56993 SGTC_2036 5160441 105 µM 1.60741482946946 0.139901505749235 no 500 0.0539816995742843 115 134534 YIL048W NEO1 SGTC_3037 9091026 49.47 µM 1.60170416248034 0.140767428827117 no 501 0.0546105221383976 92 25236398 YIL048W NEO1 SGTC_261 5-fluorouridine 15.376 µM 1.60130953538754 0.140827401193727 no 502 0.054654189049552 77 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2893 9048488 25.97 µM 1.5967303194169 0.141524582617521 no 503 0.0551629170736476 98 6467338 SGTC_411 enrofloxacin 100 µM 1.59667371823738 0.141533214701682 no 504 0.0551692285058435 72 71188 A bacterial gyrase inhibitor. SGTC_2120 5538279 151.968 µM 1.59589955000219 0.14165131669592 no 505 0.0552556110140856 66 2058197 SGTC_1975 st070967 30.8 µM 1.5925094268972 0.142169277611042 no 506 0.0556351433285617 118 261391 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.59209755229015 0.142232293200039 no 507 0.0556813935026202 77 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2585 alliin 100 µM 1.59127959729762 0.142357493910697 no 508 0.0557733331691848 79 87310 A garlic compound which reacts with lipids. SGTC_1720 st037298 9.481 µM 1.59117486339589 0.142373530443297 no 509 0.0557851141010695 90 597396 SGTC_2446 5162541 200 µM 1.58666118713947 0.143065812021232 no 510 0.0562947006713518 73 1549321 SGTC_1937 st074714 47.2 µM 1.58604815888066 0.143160009871392 no 511 0.0563641926930537 71 17250970 SGTC_1267 0828-0272 9.49 µM 1.57618239837353 0.144681744396735 no 512 0.0574918868914065 89 745334 SGTC_2273 7815444 169.05 µM 1.5752694729694 0.144823106383165 no 513 0.0575971285882127 95 2824616 SGTC_681 1642-0006 26.6 µM 1.5743592478032 0.144964142815778 no 514 0.057702209788498 88 4446530 SGTC_1489 4065-0444 182 µM 1.57382204630226 0.14504742381771 no 515 0.0577642978708942 75 2877968 SGTC_2161 5662504 8.5105 µM 1.57244498639769 0.14526105301951 no 516 0.0579236940912934 88 2859334 SGTC_2173 5763948 167 µM 1.56966216892737 0.145693409289156 no 517 0.0582468634255752 88 2867177 SGTC_3151 9099821 49.47 µM 1.56732185791704 0.146057683987791 no 518 0.0585197393798163 103 17174189 SGTC_2842 9000675 19.48 µM 1.56332804393875 0.146680742119158 no 519 0.0589877276665403 90 2989072 SGTC_1391 3442-0225 151 µM 1.56146133608714 0.146972570084865 no 520 0.0592074698011574 73 5227075 SGTC_569 4130-2812 160 µM 1.56118502299496 0.147015799989827 no 521 0.0592400508583123 79 743552 SGTC_565 1418-0001 44.5 µM 1.55883592473568 0.147383666922257 no 522 0.0595176095108048 95 2862145 SGTC_2425 5628681 7.85 µM 1.55756792294503 0.147582491124483 no 523 0.0596678537891682 94 5714958 SGTC_2302 7771753 200 µM 1.55715887931631 0.147646667966936 no 524 0.0597163843110512 85 2203047 SGTC_2244 6635614 200 µM 1.5556410011253 0.147884978607648 no 525 0.0598967416191052 55 836499 SGTC_3122 9126309 49.47 µM 1.55423017963969 0.148106711866565 no 526 0.0600647605516694 106 17591206 SGTC_2171 5739187 198.077 µM 1.55390834542779 0.148157324431125 no 527 0.0601031403938906 82 2262761 SGTC_1564 D-Arginine 115 µM 1.55119199153305 0.148584967010889 no 528 0.0604278403902045 111 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1478 0453-0656 35.7 µM 1.54959151839577 0.148837319607919 no 529 0.0606197949919836 94 5258496 SGTC_1692 fluoroquinolonic acid 71 µM 1.54833036001621 0.149036372825108 no 530 0.0607713892338975 73 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2775 cyproheptadine 69.59 µM 1.54726970311623 0.14920391777326 no 531 0.0608991120958337 93 2913 A selective serotonin reuptake inhibitor. SGTC_1292 0kpi-0043 232 µM 1.54622479592347 0.149369097791269 no 532 0.0610251435299423 80 3333905 SGTC_380 3970-0968 6 µM 1.54564864947077 0.149460227817121 no 533 0.0610947225577454 85 2891601 SGTC_691 1548-0686 185 µM 1.54387893715428 0.149740378123928 no 534 0.0613088317948274 116 46495133 SGTC_2112 5488546 200 µM 1.54357994831826 0.149787743444779 no 535 0.0613450628783308 95 600757 SGTC_3097 9117246 49.47 µM 1.54158140404112 0.150104606200355 no 536 0.0615876736649811 85 16423892 SGTC_517 1365-0151 113 µM 1.53669905168787 0.150880565410518 no 537 0.0621835117306545 85 768657 SGTC_2895 9054447 58.44 µM 1.53496353604812 0.151157035507336 no 538 0.0623963925770599 86 2697450 SGTC_1443 4112-3303 14 µM 1.5348241962733 0.151179247137541 no 539 0.0624135088090297 104 704433 SGTC_1040 k898-0338 155 µM 1.53065957435119 0.151844116175132 no 540 0.0629267748832317 85 20969351 SGTC_1190 1486-1332 13 µM 1.5295200760793 0.152026371553375 no 541 0.0630677829972397 87 4150046 SGTC_1259 0671-0132 43 µM 1.52316390814678 0.153045664228974 no 542 0.0638588516174051 95 X1259 SGTC_1998 st075797 76.8 µM 1.52245597834684 0.153159469537742 no 543 0.0639474338558831 92 24208315 SGTC_2833 9001315 45.46 µM 1.51854399384018 0.153789362999183 no 544 0.0644386588553257 99 2989378 SGTC_1130 3454-2858 15.9 µM 1.51713403199805 0.154016809706125 no 545 0.0646164237500187 120 715628 YIL048W NEO1 SGTC_712 r015-0009 80.6 µM 1.51690820694497 0.154053259135684 no 546 0.0646449306319431 80 6813872 YLR060W FRS1 SGTC_1428 4049-0204 61.7 µM 1.51688592764083 0.154056855449535 no 547 0.0646477435750177 99 X1428 SGTC_1706 st031321 9.9705 µM 1.51125696914172 0.154967258900465 no 548 0.065361496393914 92 6103185 SGTC_3270 9137563 49.47 µM 1.5085895814551 0.155399908936497 no 549 0.0657018491424597 75 17015724 SGTC_1527 coumarin 137 µM 1.50570784155753 0.155868221736373 no 550 0.066071095039327 100 323 A hepatotoxic, DNA x-linker. SGTC_2105 5350118 200 µM 1.50546571842596 0.155907611598306 no 551 0.0661021920625633 106 2133313 SGTC_1947 st076332 61.6 µM 1.50209402838221 0.156456817724719 no 552 0.0665364134462675 89 24208416 SGTC_3200 9114385 49.47 µM 1.49794673257188 0.157134105511693 no 553 0.0670735452884889 96 17018030 YLR208W SEC13 SGTC_2544 sphondin 68.51 µM 1.49642208234324 0.157383577520309 no 554 0.0672718493102564 120 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2228 7354201 200 µM 1.49608683925611 0.157438466812491 no 555 0.0673155135156877 111 753451 SGTC_1676 st018489 23.4 µM 1.49543908030827 0.157544559909711 no 556 0.0673999438463917 84 3696235 SGTC_2911 7942208 15.64 µM 1.49507905692946 0.157603546588828 no 557 0.0674469054631244 75 1243384 SGTC_1609 st001574 46.4 µM 1.49489118631976 0.157634333304701 no 558 0.0674714214318822 103 3960012 SGTC_157 1348-1695 65.819 µM 1.49266814483896 0.15799892732889 no 559 0.0677620379088425 130 5380510 SGTC_2996 9066192 71.4286 µM 1.4908589228983 0.158296060424461 no 560 0.0679992689629897 96 6472854 SGTC_2540 epiandrosterone 100 µM 1.48967578913951 0.158490567626107 no 561 0.0681547517555666 102 441302 A steroid. SGTC_225 nsc-122657 1.016 µM 1.48868255486551 0.158653976336819 no 562 0.0682854904687255 83 275685 SGTC_934 2950-0684 338 µM 1.48733140250479 0.158876447673272 no 563 0.0684636522966118 107 1121253 SGTC_3197 9113331 49.47 µM 1.48665171580016 0.158988437408506 no 564 0.0685534106866335 102 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_377 3970-0964 33.1 µM 1.48611793417148 0.15907642309885 no 565 0.0686239646868722 101 16481235 SGTC_1372 2752-0194 270 µM 1.48461871935434 0.159323716188076 no 566 0.0688224269241259 81 823334 SGTC_1437 4092-1038 11.6 µM 1.48158410311382 0.159825041335928 no 567 0.0692254957293492 107 3977136 SGTC_3079 9117512 49.47 µM 1.48085061950695 0.159946369097808 no 568 0.0693231920897932 106 7185044 SGTC_2719 novobiocin 32.65 µM 1.47730749026813 0.160533296972258 no 569 0.069796615545962 90 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2377 9073351 62.6 µM 1.47582182438958 0.160779819228566 no 570 0.0699958651510155 117 7337946 YHR072W ERG7 SGTC_511 blebbistatin 171 µM 1.47203739106795 0.161408900992727 no 571 0.0705053903756183 94 3476986 A myosin inhibitor. SGTC_1518 st038567 90.8 µM 1.46500149650494 0.162582729590808 no 572 0.0714602547311957 96 77966 SGTC_1826 st055655 41.6 µM 1.46439088326344 0.162684862096876 no 573 0.0715435888276311 105 676168 SGTC_1273 0849-0096 14.1 µM 1.46024724122224 0.163379038990252 no 574 0.0721110680643946 113 5286025 SGTC_2829 7992743 58.44 µM 1.45832109919907 0.163702376218205 no 575 0.0723760285824169 86 16462845 SGTC_2319 6033012 152.6 µM 1.45513735893431 0.16423773384038 no 576 0.0728156192028809 94 847246 SGTC_1272 0839-0021 27 µM 1.45448028168358 0.164348364974958 no 577 0.0729065982044267 110 5027250 SGTC_750 4073-0104 132 µM 1.4536313551704 0.16449136900617 no 578 0.0730242694832577 63 22330957 SGTC_999 SEC7.066 22.7 µM 1.45174467379058 0.164809474432413 no 579 0.0732863063164933 120 740511 YDR170C SEC7 SGTC_3056 9094900 49.47 µM 1.44684848331956 0.165636858065077 no 580 0.073969682170242 95 25236784 SGTC_2449 5812982 45.77 µM 1.44660440153979 0.165678174437663 no 581 0.0740038763723949 72 776185 SGTC_2059 5238311 157 µM 1.44568252744464 0.165834282629182 no 582 0.0741331336351696 106 703021 SGTC_1226 3909-7979 35.4 µM 1.44461430568171 0.166015291903176 no 583 0.074283126119257 121 6615510 SGTC_3158 9100007 49.47 µM 1.44387326731268 0.166140935200349 no 584 0.0743873137940561 79 19297233 SGTC_2097 5376186 200 µM 1.44052535458956 0.166709340340611 no 585 0.074859410999351 102 742755 SGTC_590 k048-0076 22.4 µM 1.43754626895853 0.167216180214843 no 586 0.0752814178409308 107 6832814 SGTC_2240 6690706 185.951 µM 1.4360389777857 0.167472997755624 no 587 0.075495625184212 90 805876 SGTC_1473 k844-0725 134 µM 1.43530105926824 0.167598819503367 no 588 0.075600663027594 123 54682906 SGTC_399 oxolinic acid 75 µM 1.43497441098343 0.167654535412419 no 589 0.0756471947984046 105 4628 A DNA gyrase inhibitor. SGTC_2514 salinomycin 42.74 µM 1.43457482429548 0.167722708535818 no 590 0.0757041464736143 113 23682228 A polyether potassium ionophore. SGTC_1429 4049-0205 9.46 µM 1.43453529470068 0.167729453614432 no 591 0.07570978226165 93 22774478 SGTC_1160 4092-0570 10.5 µM 1.43168719040698 0.168215895670624 no 592 0.0761166819943307 111 4994975 SGTC_70 0141-0289 43.283 µM 1.42993677704591 0.168515307411646 no 593 0.076367582728485 120 352408 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.42955639347612 0.168580418081873 no 594 0.0764221892851991 127 5393153 SGTC_2981 9013952 38.96 µM 1.42877528979928 0.168714171143998 no 595 0.076534414969441 93 2996344 SGTC_1147 3809-1045 12.3 µM 1.42863018699688 0.168739025475638 no 596 0.0765552765284523 115 325925 SGTC_1452 4194-0072 190 µM 1.42507583986055 0.169348576237016 no 597 0.0770676398213656 115 1343545 SGTC_567 1080-0542 68.4 µM 1.41722023917659 0.170700774752648 no 598 0.0782092731184844 94 5950415 SGTC_1603 st002045 67.8 µM 1.41626929505051 0.170864930121903 no 599 0.0783483370748691 92 5887985 SGTC_2465 5809242 33.21 µM 1.4161725862348 0.170881629999683 no 600 0.0783624900541914 110 2731748 SGTC_1481 3346-2004 36 µM 1.41598196565615 0.170914549812324 no 601 0.0783903923506474 125 2770522 SGTC_559 1550-0661 158 µM 1.41561289827767 0.170978298581548 no 602 0.0784444364038054 98 5830875 SGTC_428 3448-4153 16.5 µM 1.41399395507296 0.171258117272313 no 603 0.0786818386825064 106 3834874 SGTC_1189 1431-2119 7.28 µM 1.41391756353587 0.171271328041243 no 604 0.078693054195867 127 3107275 SGTC_1251 0490-5699 265 µM 1.4122794827783 0.171554766272756 no 605 0.0789338425685141 117 3883818 SGTC_1030 k029-0042 36.7 µM 1.41146918176478 0.171695083947153 no 606 0.0790531582455716 101 6080581 SGTC_3299 9121982 43.1275 µM 1.41093027756725 0.171788445136977 no 607 0.0791325867224073 94 17594604 YPL160W CDC60 SGTC_1051 3253-3903 78 µM 1.40812212214201 0.1722754619533 no 608 0.0795474557405427 130 5509239 SGTC_355 1311-2252 105 µM 1.40695304651292 0.172478473539113 no 609 0.0797206561139306 104 5338538 SGTC_600 1495-0418 41.6 µM 1.40647749200675 0.172561097868699 no 610 0.0797911918203912 133 5377768 SGTC_1775 st081588 35.1725 µM 1.40474835827681 0.172861735661051 no 611 0.0800480601374601 119 1426443 YGL099W LSG1 SGTC_2561 acetosyringone 100 µM 1.40121910874222 0.173476387819954 no 612 0.0805742808982482 115 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1755 st041960 45.185 µM 1.40108292524949 0.173500133302492 no 613 0.0805946384628741 128 2257073 SGTC_3198 9112019 49.47 µM 1.39840824316545 0.173966920492758 no 614 0.0809952546011438 121 45595555 SGTC_1840 st055363 71 µM 1.39666317747559 0.17427190048042 no 615 0.081257441088789 97 676033 SGTC_485 niflumic acid 177 µM 1.39511882158319 0.174542086201895 no 616 0.0814900056627778 93 4488 A COX2 inhibitor. SGTC_3067 9117431 49.47 µM 1.39106673351881 0.175252264635214 no 617 0.0821025957211164 150 17150885 SGTC_583 1488-1091 88.9 µM 1.38590449560699 0.176159660731486 no 618 0.0828880339492838 136 4303273 SGTC_1529 apigenin 74 µM 1.38515151405848 0.176292264688934 no 619 0.0830030714635239 118 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_394 menadione 8.33 µM 1.38337480149025 0.176605403264644 no 620 0.0832749864332847 125 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2644 guaiazulene 100 µM 1.38192471493754 0.176861235813292 no 621 0.0834974091932009 85 3515 A coloring agent. SGTC_2367 9070478 135.38 µM 1.37948084820814 0.17729292646802 no 622 0.0838732735766151 115 572802 SGTC_302 1094-0063 18.9 µM 1.37743528443488 0.177654771002699 no 623 0.0841888550920497 142 5440289 SGTC_1877 wortmannin 25 µM 1.37594900298275 0.17791797487257 no 624 0.0844187112078704 113 312145 A covalent inhibitor of PI 3-kinase. SGTC_1857 st056007 79.3 µM 1.37238813372749 0.178549564874341 no 625 0.0849713210792601 84 619834 SGTC_2961 9083290 32.55 µM 1.37202096636537 0.178614769421288 no 626 0.0850284554902734 107 17741490 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.36945745630596 0.179070435993467 no 627 0.0854281623509039 102 5379071 SGTC_3286 9117135 37.221 µM 1.36917658637799 0.179120405331101 no 628 0.085472041471303 109 3438150 SGTC_91 0417-1751 58.384 µM 1.36887141574966 0.17917470792825 no 629 0.0855197361183218 124 6795624 SGTC_651 3253-0966 34.4 µM 1.36300632514469 0.180220363706957 no 630 0.0864402585949448 114 781462 SGTC_316 k060-0003 58.6 µM 1.35837639747768 0.181048508221463 no 631 0.0871721398355775 113 6152314 SGTC_931 2812-0076 566 µM 1.35630742932224 0.181419349346973 no 632 0.087500686331645 122 3450959 SGTC_2782 7736369 71.43 µM 1.35588518150156 0.18149509128664 no 633 0.0875678515327503 132 2950836 YOL077C BRX1 SGTC_1801 st050089 28.441 µM 1.3519255886556 0.182206317650723 no 634 0.0881995603763056 129 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2998 9066762 71.4286 µM 1.34930268194787 0.182678404786786 no 635 0.0886198822753531 108 4945196 SGTC_3148 9097893 49.47 µM 1.34669294073415 0.183148879558857 no 636 0.0890395733871293 112 17174100 SGTC_1469 k284-2957 126 µM 1.34634842853402 0.183211043404207 no 637 0.0890950872070636 126 23884841 SGTC_3146 9095609 49.47 µM 1.34464401546547 0.183518781574141 no 638 0.08937011099962 105 17173999 SGTC_2460 5552655 174.22 µM 1.34285477576635 0.183842181915003 no 639 0.0896595013339552 137 5401989 SGTC_3309 9129340 25.759 µM 1.34139868564737 0.184105628157914 no 640 0.089895522049449 101 17158987 SGTC_2529 gangaleoidin 93.61 µM 1.34088861841399 0.184197968723738 no 641 0.0899783090354349 98 4565183 SGTC_2966 9084041 48.03 µM 1.34023168227391 0.184316940320482 no 642 0.0900850171853821 110 17741380 SGTC_282 k297-0036 65.7 µM 1.3393128033104 0.184483430136975 no 643 0.0902344311997456 120 5061378 SGTC_557 1315-0110 16.2 µM 1.33797487778238 0.184726013345703 no 644 0.0904523131579281 111 6833801 SGTC_1747 st037496 66.6 µM 1.33732993927894 0.184843019842945 no 645 0.0905574811994362 144 723305 SGTC_945 3381-0768 11.3 µM 1.33720683215424 0.184865359506627 no 646 0.0905775661942254 109 1126236 YIL048W NEO1 SGTC_3355 9151058 44.0485 µM 1.3359975923366 0.18508488368001 no 647 0.090775030131009 114 17015728 SGTC_2806 7952793 58.44 µM 1.33470531779862 0.185319660808447 no 648 0.0909864062116156 116 2972490 SGTC_1797 st048695 56.8 µM 1.33394641486571 0.185457622490673 no 649 0.0911107092705915 128 592262 YIL048W NEO1 SGTC_441 propafenone 146 µM 1.33267446539214 0.185688994309895 no 650 0.0913193281774606 134 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_129 0088-0017 176.636 µM 1.33242472733862 0.185734443512056 no 651 0.091360330546154 104 182446 SGTC_1024 4507-0395 26 µM 1.32858016684871 0.186434976006758 no 652 0.0919932594684467 121 4201836 SGTC_368 fentichlor 4.58 µM 1.32752420816715 0.186627672515152 no 653 0.0921676687154889 116 7329 A pesticide. SGTC_2215 7188065 200 µM 1.32262767329896 0.18752282690467 no 654 0.0929796133564577 112 940217 SGTC_493 zm226600 134 µM 1.32143925366466 0.187740485956686 no 655 0.093177472412014 127 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1037 k284-1091 78.7 µM 1.31005455913447 0.189833492536237 no 656 0.0950886896241541 122 3334711 SGTC_1486 3970-0793 4.53 µM 1.30837391279981 0.190143679973037 no 657 0.0953732582142349 137 2844330 SGTC_2537 larixol 68.93 µM 1.30772139865176 0.190264194723231 no 658 0.0954839113014004 135 6708759 SGTC_3213 9129884 49.47 µM 1.30621106767702 0.19054332212673 no 659 0.0957403950389272 120 17190742 SGTC_2152 5568786 200 µM 1.30567778938168 0.190641938421219 no 660 0.0958310770921562 130 5399883 SGTC_787 4152-0075 138 µM 1.30496940544142 0.190772984501012 no 661 0.095951632910656 122 9566539 SGTC_2394 5221648 200 µM 1.30400420189461 0.190951629358555 no 662 0.0961160748559871 148 788586 SGTC_2698 st077697 67.5 µM 1.30384885704483 0.190980390969364 no 663 0.0961425603385032 117 3154499 SGTC_1512 0259-0544 12.2 µM 1.30148746704793 0.191417922035238 no 664 0.0965458258429113 134 18476 SGTC_1913 st060213 96.1 µM 1.30115189540545 0.191480148365473 no 665 0.0966032336603718 128 688959 SGTC_2883 9059145 45.46 µM 1.2994234923946 0.191800849007218 no 666 0.0968993169075834 146 16476510 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.29847007572619 0.191977893619981 no 667 0.0970629263509279 127 94937 An inhibitor of serotonin biosynthesis. SGTC_741 4582-0002 126 µM 1.29578278587148 0.192477447648559 no 668 0.0975251651595029 136 2912688 SGTC_1690 st023502 41.2 µM 1.29411637925308 0.192787623305147 no 669 0.0978126123608944 133 24207482 SGTC_1451 4152-0210 104 µM 1.2939924102834 0.192810710397048 no 670 0.0978340212104822 121 659563 SGTC_3115 9123671 49.47 µM 1.29299213871277 0.192997055590933 no 671 0.0980068890165298 119 3286988 SGTC_143 4032-1194 15.74 µM 1.2919272591607 0.193195557720531 no 672 0.0981911682972528 151 1806963 SGTC_338 4055-0136 114 µM 1.29111134365237 0.193347735237466 no 673 0.0983325355647924 107 2900563 SGTC_2661 dactinomycin 12.96 µM 1.29053384283461 0.193455489898151 no 674 0.0984326846422908 111 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1638 st008370 60.6 µM 1.28811446418331 0.193907314760838 no 675 0.0988530605260839 137 24207134 SGTC_802 4112-3352 742 µM 1.28725960148094 0.194067116098209 no 676 0.0990019096815311 117 704594 SGTC_2180 6301957 200 µM 1.28567393725484 0.194363740101757 no 677 0.099278440377148 126 845462 SGTC_2357 9067248 200 µM 1.28317307889892 0.19483212650405 no 678 0.0997157227096846 127 9150235 SGTC_1392 3455-1037 33.9 µM 1.28059251473747 0.195316160017186 no 679 0.100168415267214 117 981132 SGTC_2736 butenafine 14.65 µM 1.27941888999421 0.195536536968387 no 680 0.100374792663647 124 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_130 0136-0219 337.655 µM 1.27881171920737 0.195650607479778 no 681 0.100481683020737 136 234244 SGTC_1985 st071382 65.5 µM 1.2782388063917 0.19575827890761 no 682 0.100582618511014 146 6123237 SGTC_881 0833-0569 170 µM 1.27542974017559 0.196286726241293 no 683 0.101078588883963 118 5418700 SGTC_286 k060-0067 22.9 µM 1.26990883174629 0.197327847964008 no 684 0.102058553430834 143 5985051 SGTC_1973 st070275 50.2 µM 1.2680931815915 0.197670968110148 no 685 0.102382338091654 94 17118334 SGTC_1769 st044406 64.4 µM 1.2674190834207 0.197798450391349 no 686 0.102502739884903 168 670903 SGTC_1782 st039423 80.636 µM 1.2664663461123 0.197978712295022 no 687 0.102673085395042 120 2068169 SGTC_322 k048-0136 19.3 µM 1.26624251865137 0.198021075780175 no 688 0.102713134654592 139 6823282 SGTC_548 1436-0017 110 µM 1.26607637215312 0.198052525616487 no 689 0.102742870448898 132 9677137 SGTC_657 3534-0529 86.7 µM 1.26536099705861 0.198187973269422 no 690 0.102870974982347 133 1049549 SGTC_2864 9034755 47.6 µM 1.26356275943299 0.198528694763629 no 691 0.103193503640279 114 4930451 SGTC_1380 2291-0730 164 µM 1.26256137133943 0.198718586084247 no 692 0.103373428804694 122 2999191 SGTC_566 0958-0068 16.5 µM 1.25974464034957 0.199253304401521 no 693 0.103880748048682 136 6815365 SGTC_2386 9075165 157.42 µM 1.25612131473457 0.199942416646309 no 694 0.104535994652169 136 16452277 SGTC_1685 st024049 53.0905 µM 1.25604701029958 0.199956563421043 no 695 0.104549463216413 133 1941139 SGTC_2258 7960471 200 µM 1.25588785611023 0.199986866712376 no 696 0.104578316039652 122 2974708 SGTC_2749 bexarotene 57.39 µM 1.25506754748957 0.200143098981565 no 697 0.104727120037486 129 82146 An retinoic acid receptor inhibitor. SGTC_2560 caryophyllene 100 µM 1.2545068766094 0.200249924013376 no 698 0.104828913925947 152 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2622 2-methoxyxanthone 59.94 µM 1.25311077299638 0.200516073486491 no 699 0.105082697981546 127 71034 A hepatoprotective. SGTC_1014 4130-3005 69.3 µM 1.25136159238435 0.200849832263847 no 700 0.105401291656982 129 743608 SGTC_1723 st034307 2.5525 µM 1.24940366441756 0.201223816996466 no 701 0.105758734414803 154 867466 SGTC_1300 1094-0077 113 µM 1.24926965079149 0.201249430259695 no 702 0.105783232180247 132 5532636 SGTC_2857 9024691 58.44 µM 1.23725317471575 0.20355400835805 no 703 0.107996552940303 145 16478292 SGTC_136 0097-0015 404.482 µM 1.2371306368681 0.203577590042338 no 704 0.108019293713831 139 4861337 SGTC_1574 spiramycin 23.7 µM 1.23665073801715 0.203669959422771 no 705 0.108108387317176 145 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2236 dapsone 200 µM 1.23497101897706 0.203993463070277 no 706 0.108420645103676 108 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2290 7904846 200 µM 1.2345195502501 0.204080465369653 no 707 0.108504683149098 131 2962154 SGTC_641 4092-0595 30 µM 1.23441688385091 0.204100253241495 no 708 0.108523800387585 144 786260 SGTC_1770 st043884 66.3 µM 1.23370067532037 0.204238326718653 no 709 0.108657231096741 159 670149 SGTC_828 2074-0507 139 µM 1.22889713860065 0.205165807919574 no 710 0.109555187219489 135 X828 SGTC_495 decylubiquinone 155 µM 1.22806529172314 0.20532667725456 no 711 0.10971122947136 133 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_718 1130-0073 349 µM 1.22740020816345 0.205455350422775 no 712 0.109836104105846 137 6740020 SGTC_2085 5307070 144.047 µM 1.22723228832842 0.205487845304366 no 713 0.10986764848997 156 2840351 SGTC_3160 9100216 49.47 µM 1.22333869850122 0.206242165838899 no 714 0.11060089823424 123 17191039 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.22065056419159 0.206763905159091 no 715 0.111109176387018 121 2374 Ca(2+)-ATPase inhibitor. SGTC_2168 5727979 200 µM 1.21963166200021 0.206961867677977 no 716 0.11130226908301 133 695210 SGTC_187 1488-2104 32.728 µM 1.21915898823286 0.207053741542088 no 717 0.111391927262398 126 2852859 SGTC_2485 5633444 17.78 µM 1.2184284903503 0.207195776275921 no 718 0.111530591952952 143 5724239 SGTC_1711 st032263 62.8 µM 1.21812687734337 0.207254437361615 no 719 0.111587880800539 135 3958979 SGTC_2818 7996756 12.99 µM 1.21553690559264 0.207758568305969 no 720 0.112080690908197 141 2241621 SGTC_2575 plumbagin 510 nM 1.2122194779864 0.208405353491842 no 721 0.112714188688477 153 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2917 7979103 53.79 µM 1.20917143440258 0.209000663516866 no 722 0.113298494864313 125 2980565 SGTC_1781 st038725 66.3 µM 1.20864135175931 0.209104295513005 no 723 0.113400331209282 165 4270275 YIL048W NEO1 SGTC_1244 0416-0015 52.5 µM 1.20661993276245 0.20949976372653 no 724 0.113789273382748 134 96201 SGTC_911 3456-4043 236 µM 1.2060640570725 0.209608591727931 no 725 0.113896396163292 140 914281 SGTC_2423 st077119 87.2 µM 1.20592392922988 0.209636030865199 no 726 0.113923411531012 132 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1362 1611-0397 101 µM 1.20171605502353 0.210460979568371 no 727 0.114736779303141 144 27816 SGTC_1266 0828-0227 32.9 µM 1.20093793140584 0.210613738266133 no 728 0.11488763950747 142 3913820 SGTC_677 0929-0063 136 µM 1.2006767175488 0.210665033503014 no 729 0.114938314462263 132 1539583 SGTC_1629 st005085 44.9 µM 1.20060500845665 0.210679116484001 no 730 0.114952228660488 158 24207091 SGTC_1442 4112-3290 3 µM 1.19466332722317 0.211847923615116 no 731 0.116109298067235 133 704353 SGTC_301 4119-0100 24.5 µM 1.19163418963297 0.212445252098277 no 732 0.116702356471227 139 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_371 0195-0006 7.36 µM 1.18859167813128 0.213046207197194 no 733 0.117300192092224 133 3928593 SGTC_3350 9150499 3.57 µM 1.18710725200546 0.213339769795139 no 734 0.117592659097546 142 4910996 YPR165W RHO1 SGTC_3083 9117465 49.47 µM 1.18583253850886 0.213592047375696 no 735 0.117844219420131 140 16420915 SGTC_3114 9122766 49.47 µM 1.18451851997211 0.213852285636867 no 736 0.11810393478593 123 17176985 SGTC_2624 nerol 100 µM 1.18364236094954 0.214025909405712 no 737 0.118277332146392 151 637566 A natural product oil. SGTC_2172 5754775 163.918 µM 1.18244075479684 0.214264158672577 no 738 0.118515430116583 179 2263357 SGTC_556 4058-0063 51.5 µM 1.17869157015296 0.215008521721409 no 739 0.119260506791499 146 6615692 SGTC_2973 9094665 17.96 µM 1.17829764293814 0.215086819105873 no 740 0.119338983577299 175 25237061 YIL048W NEO1 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.17663387145517 0.21541769461674 no 741 0.119670836208578 183 2346 DNA damaging agent; causes G2/M arrest. SGTC_2023 5144124 124 µM 1.17028195218312 0.216683618126139 no 742 0.120943761180683 136 2830192 SGTC_208 k072-0098 12.366 µM 1.16911904331671 0.216915848393754 no 743 0.121177836197576 153 5948901 SGTC_2339 9000433 200 µM 1.16860976512823 0.217017595377112 no 744 0.121280446042188 131 2988954 SGTC_2869 9037858 32.47 µM 1.16706936431029 0.217325514719278 no 745 0.121591179287263 142 27187042 SGTC_209 4077-0173 175.592 µM 1.16654161909426 0.217431066662273 no 746 0.121697765862199 136 15993494 SGTC_1630 st005209 31.3 µM 1.16404922454457 0.217929959049904 no 747 0.122202031931107 143 3367314 SGTC_957 1187-1561 14.1 µM 1.15709234625558 0.219325976188061 no 748 0.123617316676675 148 1538454 SGTC_112 phenothiazine 287.218 µM 1.15684301359554 0.219376104279819 no 749 0.123668252289955 145 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.15677011686744 0.219390761340632 no 750 0.123683146976002 161 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2073 5212005 126 µM 1.15558130220914 0.2196298710686 no 751 0.123926229831701 158 691789 SGTC_2817 7995342 71.43 µM 1.15249705549202 0.220250911822469 no 752 0.124558439514496 135 18879975 SGTC_3280 9140961 49.47 µM 1.14676189967683 0.221408409905537 no 753 0.125740019908246 156 4901226 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.14513686676125 0.22173701352452 no 754 0.126076232897964 168 616764 SGTC_2774 tamoxifen 10.92 µM 1.14194519770072 0.222383222509205 no 755 0.126738399922217 149 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_3352 9151559 45.5865 µM 1.13949026048579 0.22288099735028 no 756 0.127249364127429 136 17159339 SGTC_1850 st056238 17 µM 1.13930453590669 0.22291868156678 no 757 0.127288078583435 160 5393177 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.13805032863151 0.223173259943393 no 758 0.127549733713077 148 97141 SGTC_2470 5664817 21.68 µM 1.13749536844604 0.223285958289097 no 759 0.127665629838149 144 2859561 SGTC_3214 9129694 49.47 µM 1.13664858856157 0.223457980218377 no 760 0.127842609694047 170 17158655 SGTC_2978 9011784 42.97 µM 1.13646287991014 0.223495716701052 no 761 0.127881446214558 131 2994934 SGTC_2047 4141938 200 µM 1.13600687033186 0.223588394415504 no 762 0.127976844483963 163 3807862 SGTC_2614 arthonioic acid 13.39 µM 1.13365888376792 0.224065936445856 no 763 0.128468831419371 140 6710684 SGTC_944 3370-0224 231 µM 1.13338683388075 0.224121304368022 no 764 0.128525920330112 119 4580514 SGTC_3099 9120367 49.47 µM 1.13311248353775 0.224177148350474 no 765 0.12858350981442 166 24824940 SGTC_3045 9092950 49.47 µM 1.13225904196789 0.22435091680335 no 766 0.128762772103822 133 44120432 SGTC_1507 4075-3230 155 µM 1.13160812503358 0.224483500780967 no 767 0.128899611327932 140 659771 SGTC_1352 1496-0991 99 µM 1.13147353207783 0.224510921299024 no 768 0.128927918755397 168 3000039 SGTC_1042 0350-0096 82 µM 1.13087458225419 0.224632967924301 no 769 0.1290539414397 160 3122515 SGTC_2881 9058953 51.95 µM 1.13025025203939 0.224760226304063 no 770 0.129185395205716 147 17122249 SGTC_1286 0929-0070 131 µM 1.13022616100452 0.224765137643211 no 771 0.129190469472504 163 1420408 SGTC_1184 1269-1718 139 µM 1.12990511582258 0.224830593599082 no 772 0.12925810403699 157 5403821 SGTC_1253 0550-0034 176 µM 1.12725538936076 0.225371242787666 no 773 0.129817258941773 153 5969915 SGTC_2802 7925815 54.55 µM 1.12574866299985 0.225679002674625 no 774 0.130135959727933 154 1262923 SGTC_1825 st052143 62.6 µM 1.12562460173628 0.2257043536863 no 775 0.130162225109307 152 674173 SGTC_290 2043-6722 48.1 µM 1.12544354126289 0.225741354960755 no 776 0.13020056454721 147 773758 YLR208W SEC13 SGTC_2264 7948757 110.76 µM 1.12354687114545 0.226129162088104 no 777 0.130602652892909 140 2971411 SGTC_2049 5262831 67.185 µM 1.12340838301651 0.226157493131476 no 778 0.130632045555987 141 763417 SGTC_504 lovastatin 124 µM 1.12185259178489 0.22647590506723 no 779 0.130962560347502 165 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3285 9112818 20.8695 µM 1.11859084074799 0.227144283754373 no 780 0.131657366362181 188 17017947 YPR165W RHO1 SGTC_3353 9151644 39.2805 µM 1.1155033873878 0.227777969472049 no 781 0.13231738383755 156 4909158 SGTC_1865 st057639 52.2 µM 1.11510787108909 0.227859219218943 no 782 0.132402099469545 174 688818 SGTC_2343 7990716 14.84 µM 1.1145377890272 0.227976358183387 no 783 0.132524271094435 159 6456862 SGTC_1167 k781-0610 148 µM 1.11417400862688 0.228051124525654 no 784 0.132602271757169 166 4525169 SGTC_2268 7933382 153.85 µM 1.11353260766861 0.228182982706093 no 785 0.132739875985775 154 935025 YOR257W CDC31 SGTC_60 0986-0278 202 µM 1.11127565478553 0.22864730408178 no 786 0.133224857581034 154 3110598 SGTC_1799 st045822 46.1415 µM 1.11106373920947 0.228690928560275 no 787 0.133270457246887 161 3674992 SGTC_3259 9138485 49.47 µM 1.11100960237855 0.228702073799686 no 788 0.133282108048348 121 17646153 SGTC_488 nitrendipine 139 µM 1.11079601539383 0.228746048282499 no 789 0.133328080995317 140 4507 Dihydropyridine L-type calcium channel blocker. SGTC_362 0310-0100 9.03 µM 1.10789674433004 0.229343435771428 no 790 0.133953205901327 137 790235 SGTC_2721 ifenprodil 61.44 µM 1.10607884234065 0.229718455552766 no 791 0.134346197750878 157 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1614 st002383 48.6 µM 1.105397233119 0.229859154986255 no 792 0.134493751081194 132 1947235 SGTC_453 enantio-paf c16 10 µM 1.10064056211686 0.230842380594845 no 793 0.13552656225668 187 13871343 A lipid and platelet activating factor SGTC_3163 9099914 49.47 µM 1.0997060632431 0.231035821443971 no 794 0.13573010606117 180 16268368 SGTC_1986 st071812 45 µM 1.09905828739632 0.231169963833602 no 795 0.13587132135152 149 11838594 SGTC_2756 carbadox 75.1 µM 1.09753047050913 0.231486518493188 no 796 0.136204784159805 183 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_892 0929-0076 29 µM 1.09634037918672 0.231733265757182 no 797 0.136464922388958 157 5751038 SGTC_51 1013-0126 23.419 µM 1.09457408690907 0.232099749489646 no 798 0.136851636654418 133 1627850 SGTC_469 w7 172 µM 1.09419925318018 0.232177564315069 no 799 0.136933799476544 139 45115570 A P450 inhibitor. SGTC_1903 st060211 78.3 µM 1.09405388427484 0.232207746552036 no 800 0.136965673127481 160 688960 SGTC_2149 5554786 194.827 µM 1.09343446081636 0.23233637889506 no 801 0.137101545016893 154 745063 YPR165W RHO1 SGTC_1694 st024011 44.9 µM 1.08956648583602 0.233140516478321 no 802 0.137952076418617 164 2787533 SGTC_3282 9108498 15.4605 µM 1.08756072054045 0.233558115198603 no 803 0.13839453953102 165 16459645 SGTC_1107 amlodipine 47 µM 1.0871523171761 0.233643195251621 no 804 0.138484749928574 144 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2360 9040895 200 µM 1.08553434583758 0.233980425671824 no 805 0.138842530172025 148 4914414 SGTC_1943 st076331 65.2 µM 1.0845553635176 0.234184603792198 no 806 0.139059316865051 153 24208415 SGTC_2826 7992541 19.48 µM 1.08337310756472 0.234431308430378 no 807 0.139321423640794 174 2985066 SGTC_2496 diffractaic acid 79.83 µM 1.08141585224183 0.234840050256416 no 808 0.139756086639178 161 94870 An apoptosis inducer which activates caspases. SGTC_1285 0929-0069 65.5 µM 1.07822359713057 0.235507546588875 no 809 0.140466991845036 144 1206237 SGTC_801 0866-0028 10.1 µM 1.07624446949636 0.235921904691404 no 810 0.140908968184286 160 6849771 SGTC_2871 9038510 12.99 µM 1.07411173815797 0.236368871326504 no 811 0.141386302097944 200 4945164 SGTC_878 0828-0289 13.7 µM 1.07189540099409 0.236833853163033 no 812 0.141883508061411 174 745350 YLR208W SEC13 SGTC_1602 st001878 87.6 µM 1.07128795163614 0.236961382235592 no 813 0.142019987765973 183 595405 YLR310C CDC25 SGTC_1018 4259-0013 28.1 µM 1.07057000120068 0.237112158772705 no 814 0.142181409042014 160 6801262 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.07033063959787 0.237162438739324 no 815 0.142235253792449 179 688803 SGTC_1306 1185-0270 9.02 µM 1.06740205739409 0.237778086666067 no 816 0.142895159909256 170 1548076 SGTC_1385 3091-4834 14.1 µM 1.06732772481889 0.237793724293595 no 817 0.142911936371468 143 4072814 SGTC_3052 9092717 49.47 µM 1.0659008260399 0.238094015748374 no 818 0.143234237778504 168 25237534 SGTC_27 0485-0001 32.618 µM 1.06359623140242 0.238579457250554 no 819 0.14375582518137 166 2054479 SGTC_1098 clofazimine 15.1 µM 1.06355494835774 0.238588158077513 no 820 0.143765180236235 186 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_903 1134-0042 114 µM 1.06223527064714 0.238866385240916 no 821 0.144064445783276 166 701009 SGTC_1796 st049173 110.4 µM 1.06068121103893 0.239194254446751 no 822 0.144417400782949 166 94134 SGTC_328 k915-0120 63.5 µM 1.05755702768554 0.239854125484424 no 823 0.145128721255289 139 6624543 SGTC_3244 9134489 49.47 µM 1.05699190359502 0.23997359353133 no 824 0.14525764126816 186 16584271 SGTC_2113 5491891 107.031 µM 1.05664825368585 0.240046257479925 no 825 0.145336074723398 176 789979 SGTC_191 3914-0123 66.505 µM 1.05374239194879 0.240661174296877 no 826 0.146000437391067 178 3144412 SGTC_850 0388-0143 75.9 µM 1.05293438751576 0.24083231040423 no 827 0.146185532192325 157 67273 SGTC_401 neomycin 50 µM 1.05216638480114 0.24099503546576 no 828 0.146361609576207 162 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_742 0kpi-0133 140 µM 1.05128551946804 0.241181747550689 no 829 0.1465637378447 175 2728852 SGTC_173 1273-0061 2.693 µM 1.04405396837642 0.242717547217308 no 830 0.14823021061966 187 2847414 YPL266W DIM1 SGTC_2822 7994718 71.43 µM 1.04349301500516 0.242836900470205 no 831 0.148360007101817 197 1018011 SGTC_3255 9139072 49.47 µM 1.04091994260589 0.243384776171527 no 832 0.148956352644284 160 17646060 SGTC_1873 rapamycin 2 nM 1.03894334798258 0.243806099049067 no 833 0.149415542302011 165 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1734 st037168 69.4 µM 1.03676973862572 0.244269870880298 no 834 0.149921590917453 171 708907 SGTC_351 caspofungin 25 nM 1.03612056085225 0.244408474766163 no 835 0.150072950567335 190 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2859 9028643 45.46 µM 1.03512267113719 0.244621613645575 no 836 0.150305813071451 146 17151580 SGTC_1591 genipin 88.4 µM 1.03307083366318 0.245060179151671 no 837 0.150785375668236 174 442424 A DNA cross-linking agent. SGTC_2163 5671233 125 µM 1.03043232118137 0.245624763268127 no 838 0.151403553648673 177 701023 SGTC_1074 carmofur 3.8 µM 1.02998583680733 0.245720370246298 no 839 0.151508327108851 189 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_84 0443-0269 128.823 µM 1.02755159748691 0.24624197214195 no 840 0.152080401213831 169 6150058 SGTC_472 calcifediol 10 µM 1.02566323130268 0.246647014426026 no 841 0.152525175692667 153 5283731 A vitamin D metabolite. SGTC_3295 9122362 53.5725 µM 1.02554694588136 0.246671968551801 no 842 0.15255259304927 198 4730473 SGTC_3174 9107204 49.47 µM 1.02516507240543 0.246753925726472 no 843 0.152642652798759 184 3938802 SGTC_276 colchicine 750 µM 1.02346533344404 0.247118898233433 no 844 0.153043941299314 185 2833 A microtubule depolymerizer. SGTC_2353 9059630 146.67 µM 1.02234728174168 0.247359126631596 no 845 0.153308281182178 178 4779114 SGTC_3003 9075612 71.4286 µM 1.02024825748652 0.247810467085722 no 846 0.15380536804391 194 6501993 SGTC_870 0573-2213 57.6 µM 1.01996561214334 0.247871276168723 no 847 0.153872384975323 165 3916321 SGTC_1215 3852-0577 11.2 µM 1.01754814040666 0.248391702801223 no 848 0.154446371675518 169 2884876 SGTC_2934 9036370 36.88 µM 1.01709831540236 0.248488604111619 no 849 0.154553330807762 154 6462800 SGTC_693 4161-2696 114 µM 1.01625669606132 0.248669959853312 no 850 0.1547535820352 202 805759 SGTC_1965 Pectolinarigenin 58.4 µM 1.0159683532785 0.248732109400821 no 851 0.154822228465068 166 5320438 An anti-inflammatory. SGTC_967 1306-0166 352 µM 1.01568559151154 0.248793064045213 no 852 0.154889565742197 197 4437607 SGTC_2082 5219693 150 µM 1.01440943460075 0.249068262707392 no 853 0.155193712143632 174 2834649 SGTC_2129 girgensonine 121.053 µM 1.01412584906178 0.249129438897043 no 854 0.155261352571163 206 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_988 1497-1057 103 µM 1.01209583661627 0.249567594467183 no 855 0.1557461164304 184 3533044 SGTC_715 0868-0130 184 µM 1.01009580399517 0.249999679274407 no 856 0.156224696179387 162 2876258 SGTC_1182 1222-0449 220 µM 1.00875768562595 0.250288986350873 no 857 0.156545429498319 175 658318 SGTC_3321 9137793 26.8275 µM 1.00610675853809 0.250862652201639 no 858 0.157182108962126 191 4904192 SGTC_762 1165-0429 115 µM 1.00592746093787 0.250901477670433 no 859 0.15722523268458 190 5967793 SGTC_3349 9149703 23.001 µM 1.00521201113365 0.25105643429411 no 860 0.157397386381013 151 4910494 SGTC_2652 actinonin 100 µM 1.00514626123496 0.251070677361123 no 861 0.157413213534642 194 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2936 9038235 15.59 µM 1.00504290616846 0.251093067509011 no 862 0.157438095026132 193 4749415 SGTC_2373 9071805 200 µM 1.00168913372198 0.251820179134982 no 863 0.158246878212912 186 10149009 SGTC_3268 9137683 49.47 µM 0.999164254002544 0.252368315976641 no 864 0.158857564500778 230 1953228 SGTC_3220 9131269 49.47 µM 0.998857124479138 0.252435034905054 no 865 0.158931954376021 186 17722206 SGTC_2890 9046729 58.44 µM 0.99465075633066 0.253349735127898 no 866 0.159953076205727 181 903329 SGTC_3239 9133757 49.47 µM 0.99389481855365 0.253514302866751 no 867 0.160137038597807 189 17036923 SGTC_1155 4088-0394 48.2 µM 0.993307077365902 0.25364229298913 no 868 0.160280164794983 182 2326248 SGTC_2280 7785178 200 µM 0.990142234688865 0.254332071505695 no 869 0.161052301172684 177 2954328 SGTC_2984 9022109 38.96 µM 0.989026673409353 0.254575442635663 no 870 0.161325045742856 211 6459207 SGTC_1471 k673-0312 37 µM 0.987941882287348 0.254812217878005 no 871 0.161590556037652 192 24099884 SGTC_1809 st050081 57.6 µM 0.987116208027858 0.254992513422272 no 872 0.161792836466311 207 5036894 SGTC_2337 9009472 200 µM 0.986937790333046 0.25503148176174 no 873 0.161836568362231 171 5742383 SGTC_304 1310-0298 97 µM 0.985334429149249 0.255381812802028 no 874 0.162229913207112 217 1550234 SGTC_883 0850-0245 24.6 µM 0.983993649843128 0.255674963236539 no 875 0.162559317590488 211 6823229 YPR165W RHO1 SGTC_2135 5326629 150.42 µM 0.983516929193549 0.255779236639254 no 876 0.162676543732936 172 5020077 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.980576723471485 0.25642284001676 no 877 0.163400758726542 184 140250 A respiratory chain inhibitor. SGTC_3025 9087895 49.47 µM 0.978996196063766 0.256769161756227 no 878 0.163790929522626 191 17173641 SGTC_2200 6600604 21.907 µM 0.978100700167945 0.256965488876164 no 879 0.164012260799846 218 2904777 SGTC_815 1582-0027 36.9 µM 0.977686928259839 0.257056229954523 no 880 0.164114594412245 202 3128206 SGTC_1173 0443-0020 122 µM 0.976531072366085 0.257309799939407 no 881 0.164400678805072 192 5331295 SGTC_1981 st071826 47 µM 0.972775628168366 0.258134560301057 no 882 0.165332414059901 186 11838600 SGTC_88 0180-0332 8.668 µM 0.971944688346068 0.258317234047552 no 883 0.16553903309816 194 3101745 SGTC_395 anisomycin 6.25 µM 0.9706538770009 0.258601138721108 no 884 0.165860333515168 196 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1719 st032227 49.2 µM 0.970366467176047 0.258664374430121 no 885 0.165931928543001 189 3125804 SGTC_2727 riluzole 51.77 µM 0.970193682668751 0.258702394209291 no 886 0.165974979521084 214 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_99 0109-0120 622.8 µM 0.969494417196355 0.258856291239339 no 887 0.166149282175943 187 759414 SGTC_2428 5615643 7.78 µM 0.96932635514258 0.258893286040616 no 888 0.166191191842144 208 2253075 SGTC_2432 5630864 12.22 µM 0.969166410462007 0.258928496538449 no 889 0.166231083618667 189 5714970 SGTC_2872 9044037 25.97 µM 0.968665118282465 0.259038867910124 no 890 0.166356150883436 182 6465195 SGTC_2444 5485484 36.41 µM 0.966622347124106 0.259488883913031 no 891 0.166866429475233 214 6790631 SGTC_747 3448-8087 38.7 µM 0.96400198082094 0.26006673287255 no 892 0.167522466388566 178 5168703 SGTC_449 xestospongin c 11.1929 µM 0.962802147142675 0.2603315441121 no 893 0.167823411507429 192 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2124 5246320 200 µM 0.96242198373714 0.260415477664585 no 894 0.167918837561721 211 579342 SGTC_1279 0874-0590 65.2 µM 0.960717820596964 0.260791898830654 no 895 0.168347034215559 188 3523074 SGTC_1120 ficusin 1.78878 µM 0.960615148360235 0.260814586349866 no 896 0.168372854571383 189 6199 A DNA cross-linker. SGTC_852 0418-0143 439 µM 0.959987524840742 0.260953294604237 no 897 0.168530746788868 197 5369229 SGTC_3331 9141060 1.957 µM 0.95387510812773 0.262306153322573 no 898 0.170073432386818 182 4906567 YPR165W RHO1 SGTC_2526 patulin 37.61 µM 0.950516209001948 0.263051103559912 no 899 0.170925010894362 205 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_719 2810-4230 27.3 µM 0.94885796462399 0.263419273955507 no 900 0.171346428126102 193 721079 SGTC_214 4373-3496 70 µM 0.94673864716681 0.263890196378929 no 901 0.171885985969217 215 3779166 SGTC_770 0389-1121 67.2 µM 0.946330978183223 0.263980831560086 no 902 0.171989898855958 186 6753108 SGTC_1179 1021-1431 9.29 µM 0.944114021187509 0.264473995043303 no 903 0.172555692525295 227 2840958 SGTC_176 1486-1328 72.834 µM 0.943797130962759 0.264544525752929 no 904 0.172636663505489 187 22310231 SGTC_2684 capsaicin 100 µM 0.940466495750692 0.26528640840628 no 905 0.173489163802141 194 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_785 1270-0111 65.3 µM 0.938555107408102 0.265712637255231 no 906 0.17397960545314 200 6741994 SGTC_585 0kpi-0023 191 µM 0.937135747708105 0.266029370970497 no 907 0.174344367628587 161 64601 SGTC_1145 3546-0597 10.2 µM 0.934278748759615 0.266667496884717 no 908 0.175080061746333 206 875334 SGTC_2472 5377652 49.4 µM 0.934223011719845 0.26667995374018 no 909 0.17509443392105 210 1610903 SGTC_1435 4092-0789 56.7 µM 0.93382279521551 0.266769408089655 no 910 0.175197654447746 214 2248285 SGTC_1653 st012112 65 µM 0.933790810923926 0.266776557709526 no 911 0.175205905236385 186 720429 SGTC_1701 st028638 40.4 µM 0.93284748545659 0.266987467835644 no 912 0.175449359844113 183 3490878 SGTC_680 0417-1641 114 µM 0.930278133017799 0.267562354254614 no 913 0.176113548329982 187 2835990 SGTC_794 k038-0031 316 µM 0.929513626838204 0.26773353106645 no 914 0.176311483271453 185 6624242 SGTC_1214 0358-0031 63.7 µM 0.923875231427613 0.268997698311014 no 915 0.177775640081623 198 4301366 SGTC_336 4111-0029 111 µM 0.918919225452484 0.270111337949217 no 916 0.179068911582656 192 3131175 SGTC_2342 7990637 118.86 µM 0.91843332029094 0.270220647316616 no 917 0.179196026543702 218 2033102 YER133W GLC7 SGTC_300 r073-0011 5.04 µM 0.916465913094958 0.270663461801829 no 918 0.179711288978171 196 2735780 SGTC_3228 9131799 49.47 µM 0.916154002746766 0.270733698337959 no 919 0.179793063464969 212 17015818 SGTC_2681 menadione 3.18 µM 0.91581467088548 0.270810120033763 no 920 0.179882053676756 228 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_582 0987-0078 156 µM 0.915741516151909 0.270826596787551 no 921 0.179901242222867 216 1625765 SGTC_2755 lomerizine 42.69 µM 0.915308218548302 0.270924199334868 no 922 0.180014922892278 188 3949 A calcium channel blocker. SGTC_2762 leflunomide 42.06 µM 0.915247666118929 0.270937840483372 no 923 0.180030813118256 227 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3043 9092303 49.47 µM 0.914507751512992 0.271104554864045 no 924 0.180225053337033 190 25236084 SGTC_202 3594-0513 34.79 µM 0.914441511159443 0.271119482350585 no 925 0.180242448973352 199 708429 SGTC_3006 9075424 71.4286 µM 0.911820332737867 0.271710502537775 no 926 0.180931652522134 222 7465181 SGTC_178 4092-0806 87.505 µM 0.911511790349662 0.271780114472616 no 927 0.181012888091459 207 2169044 SGTC_468 gf-109203x 121 µM 0.910676707682055 0.27196856654615 no 928 0.181232870112316 165 2396 A protein kinase C inhibitor. SGTC_3049 9092223 49.47 µM 0.908941770304763 0.272360295378409 no 929 0.181690431756701 187 8623917 SGTC_213 1246-0773 967 nM 0.905548372565001 0.273127294748753 no 930 0.182587472742981 187 6251622 SGTC_2274 7947094 46.08 µM 0.905035351167307 0.273243344493104 no 931 0.1827233296724 204 2971028 SGTC_25 0118-0223 35.662 µM 0.904653414138289 0.273329757712757 no 932 0.182824514167718 216 5333628 SGTC_400 oxethazaine 37.5 µM 0.904252091507803 0.273420571502926 no 933 0.182930872059341 202 4621 A local anesthetic. SGTC_2071 5230951 39.92 µM 0.902868853503945 0.273733693668044 no 934 0.183297751427802 217 1799272 SGTC_3065 9113888 49.47 µM 0.901431596895772 0.274059231750253 no 935 0.183679443953766 202 16648368 SGTC_1157 4092-0394 27.6 µM 0.899853460304013 0.274416899297567 no 936 0.184099119969607 198 3659885 SGTC_433 pimozide 108 µM 0.899631902742427 0.274467131353094 no 937 0.184158086821127 189 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2194 5927483 104.545 µM 0.899469342374171 0.274503990310901 no 938 0.184201359230503 186 760979 SGTC_1309 pyrazolanthrone 13.4 µM 0.898473355009713 0.274729873917874 no 939 0.184466622098014 213 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_32 0928-0142 34.1 µM 0.897504754802396 0.274949634159912 no 940 0.184724818677779 217 2244242 SGTC_303 1348-1668 34.2 µM 0.895826258047793 0.275330663813368 no 941 0.185172781754726 208 5380509 SGTC_521 r062-0005 13.8 µM 0.895126196884901 0.275489658997809 no 942 0.18535981573865 194 2832033 SGTC_2482 5981709 142.65 µM 0.894290325021305 0.275679558118761 no 943 0.185583287565782 218 877755 SGTC_1268 0828-0275 2.46 µM 0.893973822856105 0.275751480050457 no 944 0.185667948601237 210 745337 SGTC_714 4296-0578 26.1 µM 0.891684007280131 0.276272092130033 no 945 0.186281163991822 227 1589775 SGTC_3017 9080681 49.47 µM 0.890933167873625 0.276442907785797 no 946 0.186482512595441 213 16451914 SGTC_1525 8-methoxypsoralen 92.5 µM 0.888347222260489 0.277031605401489 no 947 0.187177002828059 216 4114 Related to psoralen; DNA damaging agent. SGTC_1531 st059297 52.4 µM 0.888061011608444 0.27709679973916 no 948 0.187253966712202 217 7566702 SGTC_3265 9137266 49.47 µM 0.887653322735202 0.277189677889803 no 949 0.187363630653302 165 17224265 SGTC_3301 9125354 19.7965 µM 0.886717885019127 0.277402843349466 no 950 0.187615403398645 185 41905162 SGTC_1348 1493-0373 93.8 µM 0.885773471281685 0.277618135513425 no 951 0.187869803978081 241 3010129 SGTC_2896 9052656 71.43 µM 0.885538294599025 0.277671759980628 no 952 0.187933187591687 227 6469436 SGTC_2516 gossypol 71.55 µM 0.879135351910089 0.279133685718952 no 953 0.189663945886981 216 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_446 go6976 132 µM 0.879118708240679 0.27913749068765 no 954 0.189668457520231 217 3501 A protein kinase C inhibitor. SGTC_1388 3346-4487 254 µM 0.878666893337876 0.279240791338157 no 955 0.189790957121632 224 3345614 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.875377347966994 0.279993455734111 no 956 0.190684310400546 182 6857784 SGTC_2029 5175081 200 µM 0.873431962526263 0.280439031968812 no 957 0.191213837893182 204 1380876 SGTC_644 1498-1197 63.3 µM 0.871241143136355 0.280941233648385 no 958 0.191811249773188 216 6741615 SGTC_757 1066-0008 322 µM 0.869995198043972 0.281227035484838 no 959 0.192151514214179 210 6842497 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.869694858244134 0.281295950097494 no 960 0.192233591456154 191 6312947 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.869205429578655 0.28140826965054 no 961 0.192367389082868 214 23665772 A membrane-active detergent. SGTC_522 1273-0010 11.6 µM 0.868914773345319 0.281474982928556 no 962 0.192446874214135 220 5705015 SGTC_962 1254-0300 21.5 µM 0.868324705369867 0.281610442570084 no 963 0.19260830057686 197 7340576 SGTC_1722 st034304 3.6505 µM 0.865410350327079 0.282279940567432 no 964 0.193406801036357 208 4036148 YLR033W RSC58 SGTC_1783 st039459 87.517 µM 0.865017462603411 0.28237025495306 no 965 0.193514602128956 231 729761 SGTC_1699 st031318 29.054 µM 0.862777543743394 0.282885417778148 no 966 0.194129894088888 227 5340658 SGTC_867 0518-0118 155 µM 0.862655743448364 0.282913443773367 no 967 0.194163386009721 235 6848158 SGTC_2800 7887935 81.82 µM 0.862550448802106 0.282937672927497 no 968 0.194192342141605 213 2961002 SGTC_2456 5770359 74.46 µM 0.86227047788766 0.283002101357084 no 969 0.194269347213089 238 3118787 SGTC_3121 9125696 49.47 µM 0.859845508480608 0.283560442986607 no 970 0.194937104762231 240 1235365 SGTC_1684 st024538 14.6195 µM 0.857715331328682 0.284051344683166 no 971 0.195524836101526 217 6732859 SGTC_1617 st002906 78 µM 0.856693615516256 0.284286944404482 no 972 0.195807116348962 221 5150859 SGTC_2783 7738165 71.43 µM 0.856612255504531 0.284305709404983 no 973 0.195829605167607 226 17201110 SGTC_2979 9012552 45.46 µM 0.855570060165886 0.284546135318387 no 974 0.196117818253837 243 17100905 SGTC_1848 st056003 16.4 µM 0.854549201579022 0.284781733117678 no 975 0.19640038004967 215 146492 SGTC_920 mycophenolic acid 780.421 nM 0.853382239484193 0.285051163237693 no 976 0.196723683667958 204 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1399 3562-5772 25 µM 0.853288742431882 0.285072755247941 no 977 0.196749600707412 215 23847490 SGTC_2058 5236698 133 µM 0.852969983855218 0.285146374535292 no 978 0.196837974955307 202 766665 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.847656361884608 0.286374921333585 no 979 0.198314687851242 250 368090 SGTC_2892 9047358 58.44 µM 0.847493983395183 0.286412503911831 no 980 0.198359919615745 211 6466771 SGTC_149 3970-0822 46.1 µM 0.846579938229296 0.286624103760973 no 981 0.198614649991639 223 3114250 YBL034C STU1 SGTC_220 paclitaxel 373.376 µM 0.843799144037069 0.287268308203285 no 982 0.19939082695603 203 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1812 st052057 4.327 µM 0.836431451519742 0.288978427334333 no 983 0.201456112532389 222 3645418 SGTC_2621 lithochol-11-enic acid 100 µM 0.835891370923236 0.289103973923754 no 984 0.201608008656245 226 6708711 SGTC_1206 3978-0017 132 µM 0.83542382167919 0.289212680658584 no 985 0.20173956093543 221 3873677 SGTC_3196 9111891 49.47 µM 0.835082238168303 0.28929211209206 no 986 0.201835703279484 242 18891510 SGTC_2873 9040596 71.43 µM 0.834167752802867 0.289504815909546 no 987 0.202093229998935 241 6463863 SGTC_3327 9140648 26.9345 µM 0.829735395028315 0.290536795009563 no 988 0.203344202407344 249 8029710 SGTC_1153 4055-0057 267 µM 0.828882760671852 0.290735509819132 no 989 0.203585375640166 249 882706 SGTC_793 0488-0545 106 µM 0.828839870687905 0.290745507429828 no 990 0.203597511858721 235 292548 SGTC_3229 9132204 49.47 µM 0.827653679115469 0.291022071137245 no 991 0.203933329467991 215 17682924 SGTC_1563 conessine 56.1 µM 0.825684032875491 0.291481570645383 no 992 0.204491676086063 218 441082 An anti-amoebic, histamine inhibitor. SGTC_1425 4048-4433 7.33 µM 0.823243766900884 0.29205133009145 no 993 0.205184692264591 268 23734946 SGTC_2739 tacrine 100.86 µM 0.820047399447068 0.292798409298255 no 994 0.206094543282589 208 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_658 3253-0951 102 µM 0.816530806135776 0.293621357694419 no 995 0.207098305823606 227 1184878 SGTC_1409 3909-8004 61.9 µM 0.814656448510367 0.29406042935053 no 996 0.207634494557861 215 2119279 SGTC_105 0111-0055 734.78 µM 0.813423226779758 0.29434947919311 no 997 0.207987723473843 212 5179370 SGTC_174 3553-0389 74.3 µM 0.8110971276301 0.294895040955164 no 998 0.208654947627027 224 738071 SGTC_1341 1486-1360 280 µM 0.808626513607751 0.295475006954789 no 999 0.209365004653509 258 3976547 SGTC_1683 st010134 710 nM 0.806032556342992 0.296084491157985 no 1000 0.210112038706359 218 3818134 SGTC_2075 5212009 200 µM 0.804680074788333 0.296402503063673 no 1001 0.210502160278961 241 780898 SGTC_270 tamoxifen 5.46 µM 0.80383268456308 0.296601831502988 no 1002 0.210746805380997 257 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_366 0181-0206 4.31 µM 0.803818697085393 0.296605122240233 no 1003 0.210750845022999 220 274874 SGTC_319 1348-1596 45.5 µM 0.802548808682754 0.296903949766989 no 1004 0.211117783309101 236 5380505 SGTC_3317 9138495 8.753 µM 0.799936344186443 0.297519142346545 no 1005 0.211873839604403 249 17020139 SGTC_1902 st060212 70.5 µM 0.798918566953897 0.297758969637501 no 1006 0.212168816097127 226 688944 SGTC_1408 3909-7976 48.8 µM 0.798340164095437 0.297895302787866 no 1007 0.212336558190752 251 24152374 SGTC_1225 1216-0074 20.6 µM 0.797389412613126 0.298119462642961 no 1008 0.212612453105283 243 4241466 SGTC_1441 4106-0040 13 µM 0.797049359466136 0.298199656048269 no 1009 0.212711182627308 224 2904180 SGTC_1641 st009299 47.1 µM 0.79555439638274 0.298552323832111 no 1010 0.213145540977229 236 4046054 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.794820650017989 0.298725486920811 no 1011 0.213358918558164 258 229346 A bile salt which induces apoptosis. SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.79467832464982 0.298759080789519 no 1012 0.213400321993409 247 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_389 tpck 16.7 µM 0.792171913888888 0.299350964381565 no 1013 0.214130221376228 226 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1802 st050112 57.9 µM 0.789603992003569 0.299957924652659 no 1014 0.214879538082304 239 4662563 SGTC_443 clozapine 122 µM 0.789262956503307 0.300038574509627 no 1015 0.214979166300336 244 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1760 st045453 10.4495 µM 0.787913279773889 0.300357849307458 no 1016 0.215373716432968 261 3323419 YIL048W NEO1 SGTC_2792 7535235 81.82 µM 0.787739496495132 0.300398970024892 no 1017 0.215424548899526 229 1281891 SGTC_2016 5121758 140 µM 0.785684470061752 0.300885424523574 no 1018 0.216026181834774 262 2795203 SGTC_3057 9095946 49.47 µM 0.781968330891584 0.301765989272711 no 1019 0.217116592741363 264 24540043 SGTC_611 3453-1652 23.7 µM 0.781772911462233 0.301812327297775 no 1020 0.217174021706804 263 1560575 SGTC_1846 st056244 14.8 µM 0.781311896817854 0.301921656160875 no 1021 0.217309537339979 240 5393182 SGTC_2664 lyso-paf C-16 73.48 µM 0.777015789992469 0.302941325073475 no 1022 0.21857472725372 258 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2849 9019321 12.99 µM 0.772307349693679 0.304060626981432 no 1023 0.219966206698566 247 16489627 SGTC_1756 st041558 35.5 µM 0.768022449172348 0.305080842948254 no 1024 0.221236923949561 265 3955792 SGTC_1070 indatraline 8.81 µM 0.765268685552498 0.305737303125151 no 1025 0.222055783407902 251 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2777 climbazole 1.536 µM 0.763719571445284 0.306106865814453 no 1026 0.222517187535622 261 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_615 k087-0205 167 µM 0.761571837792424 0.306619564071092 no 1027 0.223157794174852 264 9642773 SGTC_1025 k007-0731 70 µM 0.760734205015411 0.306819623060455 no 1028 0.223407920048152 256 6256118 SGTC_1208 2323-2347 50.3 µM 0.759417431663716 0.307134235619511 no 1029 0.223801444578198 249 5412760 SGTC_3113 9123498 49.47 µM 0.756673915438315 0.30779019147218 no 1030 0.22462262297867 284 8897275 SGTC_1798 st045719 60.953 µM 0.755029834417122 0.308183574694733 no 1031 0.225115540690735 233 3980186 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.755002370881967 0.308190147833931 no 1032 0.225123779830488 243 16486 A toxic proline analog. SGTC_613 3914-0030 117 µM 0.749396629228277 0.309533114705224 no 1033 0.226809091008492 238 1145395 SGTC_3053 9095903 49.47 µM 0.748548765288884 0.309736459582729 no 1034 0.227064611236581 286 17174018 SGTC_991 3996-0057 64.7 µM 0.748480516853973 0.309752830272658 no 1035 0.227085186280577 245 715343 SGTC_2773 thioridazine 9.09 µM 0.746780840537223 0.310160651731981 no 1036 0.227597931312512 263 5452 An antipsychotic. SGTC_3224 9130643 49.47 µM 0.746337767235453 0.310267001438619 no 1037 0.227731701229824 260 17644395 SGTC_36 0335-0881 14.2 µM 0.746206223009936 0.310298578704663 no 1038 0.227771424756828 248 23828853 SGTC_983 1491-0821 12.2 µM 0.745017015040639 0.310584112201563 no 1039 0.228130716922661 248 46495113 SGTC_334 1502-1024 68.5 µM 0.744824519049472 0.3106303419826 no 1040 0.228188905165423 238 3296216 SGTC_563 tetrahydrosecaminediol 614 µM 0.74422947686484 0.310773266047521 no 1041 0.228368828984949 252 334274 A psychoactive constituent of the cannabis plant. SGTC_1347 1493-0251 600 nM 0.743910884096928 0.310849801056743 no 1042 0.228465195129834 243 3986378 SGTC_306 1672-3436 11.6 µM 0.741559283721814 0.311414975058939 no 1043 0.22917720021046 267 6797378 SGTC_3027 9089541 49.47 µM 0.739542221712652 0.311900101897554 no 1044 0.229788905713376 257 9943819 SGTC_2992 9074591 71.4286 µM 0.73907339579577 0.312012906770918 no 1045 0.229931215313214 262 17741321 SGTC_1386 3228-0095 33.8 µM 0.738967428252884 0.312038406216176 no 1046 0.229963388028112 249 870181 SGTC_2730 imipramine 71.33 µM 0.738220824397079 0.312218090374817 no 1047 0.230190135183886 240 3696 A tricyclic antidepressant. SGTC_3170 9103054 49.47 µM 0.738128822587803 0.312240235420704 no 1048 0.23021808522511 255 16432970 SGTC_1506 4226-2149 212 µM 0.737339434170173 0.312430270890843 no 1049 0.230457978496916 258 991114 SGTC_2691 st077356 60.2 µM 0.734103728515829 0.313209747889484 no 1050 0.231442760655957 268 2839272 SGTC_3136 9095672 49.47 µM 0.732976072422722 0.313481595146129 no 1051 0.231786511654251 249 17217380 SGTC_3179 9107801 49.47 µM 0.732652468939138 0.313559625878041 no 1052 0.231885210380131 237 4818259 SGTC_2412 st077135 33.4 µM 0.73222688901824 0.313662258960298 no 1053 0.232015047440196 281 13258915 SGTC_578 3460-0051 92 µM 0.730469895988913 0.314086128970818 no 1054 0.232551503840664 289 2876744 SGTC_1303 1160-0052 261 µM 0.729731209019654 0.314264408583768 no 1055 0.232777250251218 257 3562476 SGTC_591 4299-0174 154 µM 0.728551237610245 0.31454928060623 no 1056 0.233138107867466 270 5509088 SGTC_228 caffeine 993.056 µM 0.72757239576205 0.314785679182745 no 1057 0.233437691772542 228 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.727379979065073 0.314832158372705 no 1058 0.233496607848008 265 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1787 fluconazole 80 µM 0.726564384207726 0.315029201840855 no 1059 0.233746426412064 255 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1922 5578187 25 µM 0.726364726546838 0.315077446115805 no 1060 0.233807604574033 235 1350412 SGTC_720 r052-1644 49.9 µM 0.726031136480073 0.315158060183491 no 1061 0.233909841471123 255 1422863 YOR257W CDC31 SGTC_1436 4092-1007 8.32 µM 0.725617225901035 0.315258096429154 no 1062 0.234036728994361 231 2881121 SGTC_974 1326-0144 138 µM 0.725355746192185 0.315321299304172 no 1063 0.234116907288373 265 5411856 SGTC_1376 2910-0861 41.3 µM 0.724452899379854 0.315539570069587 no 1064 0.234393866766757 274 1112859 SGTC_863 0466-0191 129 µM 0.723641764259394 0.315735723666283 no 1065 0.234642847081062 271 765160 YPR165W RHO1 SGTC_1193 1488-0126 41.5 µM 0.721689158921726 0.316208127303948 no 1066 0.235242804411421 254 1384710 SGTC_1249 0481-0015 10.2 µM 0.720905013525717 0.316397924066682 no 1067 0.235483979015268 291 4227577 SGTC_1561 5-methoxyflavone 52.9 µM 0.720301807742308 0.316543958614624 no 1068 0.235669595980992 248 94525 SGTC_492 tmb-8 126 µM 0.720164055912572 0.316577311986348 no 1069 0.235711995942709 243 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2259 7964009 200 µM 0.71750628902098 0.317221119583535 no 1070 0.236530878648083 246 313134 SGTC_1101 ebselen 5.29 µM 0.715785893969369 0.317638156966447 no 1071 0.237061781908666 270 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1045 1348-1485 165 µM 0.713934954301563 0.318087097930016 no 1072 0.237633700925081 256 6810614 SGTC_2320 7373003 200 µM 0.710674720364545 0.318878509896042 no 1073 0.238642914219178 256 5415828 SGTC_2779 methotrexate 400 µM 0.708737995775475 0.319349035573945 no 1074 0.239243540733468 269 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3116 9124943 49.47 µM 0.708633568344578 0.319374414411109 no 1075 0.239275949731028 249 41905195 YPL160W CDC60 SGTC_2318 6029776 164 µM 0.707339886287222 0.319688886109027 no 1076 0.239677642109729 278 818325 SGTC_2709 st078560 56 µM 0.704780989825428 0.320311291274058 no 1077 0.240473270343549 290 17250903 SGTC_3094 9117742 49.47 µM 0.703548784347236 0.320611183465205 no 1078 0.240856907904516 288 17149698 SGTC_2714 st079313 56.9 µM 0.702581822065996 0.320846603234704 no 1079 0.241158197081836 270 2939799 SGTC_2706 st078239 82.5 µM 0.702483862864266 0.320870456720447 no 1080 0.241188730945517 273 15434492 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.701784226496054 0.321040842672275 no 1081 0.241406868549413 281 390807 SGTC_1325 1431-0015 227 µM 0.701502187531889 0.321109539695865 no 1082 0.241494834965154 250 1103340 SGTC_2254 7938975 95.19 µM 0.697263052942828 0.322142814131996 no 1083 0.242819092831422 283 2969277 SGTC_874 0599-0792 117 µM 0.696556051765778 0.32231527734012 no 1084 0.243040333769398 273 765305 SGTC_3141 9094609 49.47 µM 0.696247245040792 0.322390618496999 no 1085 0.243137002446579 287 25236309 YDL196W YDL196W SGTC_2429 5902844 64.44 µM 0.695265378264129 0.322630218023497 no 1086 0.243444503544375 279 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_137 0438-0332 85.389 µM 0.695235671120501 0.322637468442343 no 1087 0.243453810503039 290 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.693660113652564 0.323022100528292 no 1088 0.243947692646214 266 66535 A nucleotide analog. SGTC_2403 6032726 181.2 µM 0.691317071137569 0.323594444531755 no 1089 0.244683153052582 264 2881040 SGTC_1752 st044819 83.042 µM 0.690942849367945 0.323685895826919 no 1090 0.24480072844217 267 441209 YML126C ERG13 SGTC_3041 9091929 49.47 µM 0.688967860155972 0.324168714577995 no 1091 0.245421746649506 270 25236887 SGTC_1370 2001-0092 44.6 µM 0.688880909919675 0.324189977805299 no 1092 0.24544910683906 275 790957 SGTC_736 0958-0254 92.6 µM 0.687420847852942 0.324547113992727 no 1093 0.245908781890175 285 6812352 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.687351188658053 0.324564156907089 no 1094 0.245930724412322 288 4620898 SGTC_2316 5844804 197.44 µM 0.687109040552194 0.324623404053557 no 1095 0.246007008807412 271 776813 SGTC_2591 skatole 100 µM 0.685125695061387 0.325108842427594 no 1096 0.246632303594899 286 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_244 nsc-207895 1.295 µM 0.68470780102743 0.325211162971729 no 1097 0.24676416268856 243 42640 SGTC_154 3389-1638 511.116 µM 0.683529216076707 0.32549980819675 no 1098 0.247136247632705 308 5238686 SGTC_1274 0865-0114 173 µM 0.682164577394284 0.325834150299504 no 1099 0.247567445232935 264 870624 SGTC_3002 9075603 71.4286 µM 0.681819352652017 0.325918754001741 no 1100 0.247676592776298 280 20105405 SGTC_40 0327-0103 19.753 µM 0.681462514605501 0.326006213180166 no 1101 0.247789439030544 267 409036 SGTC_2089 5281248 129.67 µM 0.681102798838998 0.326094387362307 no 1102 0.247903223110486 266 2737878 SGTC_3185 9108267 49.47 µM 0.678755475176726 0.326670006173226 no 1103 0.248646404851173 275 4910486 SGTC_409 arachidonic acid 100 µM 0.67868745628379 0.326686692162255 no 1104 0.24866795786278 275 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1239 0337-0584 35.4 µM 0.677445949902682 0.326991311983041 no 1105 0.249061526291333 287 914301 YML130C ERO1 SGTC_1178 0988-0033 191 µM 0.675777469547796 0.327400877049874 no 1106 0.249590970728518 269 5392207 SGTC_627 1391-0720 175 µM 0.674734826535462 0.327656922184586 no 1107 0.249922126918051 305 997839 SGTC_1412 3909-8563 178 µM 0.67392200641896 0.327856585224001 no 1108 0.250180450210321 301 23767530 SGTC_69 0096-0274 206.684 µM 0.673713229466961 0.327907877630705 no 1109 0.250246824703344 297 6741392 SGTC_3051 9093778 49.47 µM 0.672951862310325 0.328094958124479 no 1110 0.250488958100557 306 17217378 SGTC_2493 resveratrol 26.09 µM 0.672054940166073 0.328315402052869 no 1111 0.250774360496112 250 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_594 1487-1584 10.8 µM 0.671023155843462 0.328569066119945 no 1112 0.251102889140098 298 5013332 SGTC_2557 derrustone 83.84 µM 0.670978407938733 0.328580069176348 no 1113 0.25111714239171 302 629853 An antioxidant. SGTC_1845 st056753 3.01 µM 0.668254672474888 0.32925008769174 no 1114 0.251985520901029 269 5375839 SGTC_2287 7945887 168.79 µM 0.664997997744717 0.330051925545119 no 1115 0.253025886864612 275 1245853 SGTC_1314 1222-0010 41.1 µM 0.663394913773357 0.330446913950075 no 1116 0.253538831274317 290 3526027 SGTC_1132 3456-3614 2.5 µM 0.661784426603349 0.330843916734334 no 1117 0.254054694091996 284 3125502 SGTC_806 3966-4455 5.86 µM 0.657383711531411 0.331929710878723 no 1118 0.255467111179083 282 714982 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.657054522338342 0.332010989068915 no 1119 0.25557292970643 324 6728940 SGTC_1613 st002381 52.1 µM 0.656483872843465 0.332151903546022 no 1120 0.255756420362658 281 551167 SGTC_2322 7413319 38.22 µM 0.654757326450469 0.332578396229943 no 1121 0.256312004799047 280 1840400 SGTC_570 0987-0065 62.6 µM 0.654402985234334 0.332665952673321 no 1122 0.25642610582059 277 3104428 SGTC_2195 6536160 144.242 µM 0.650470959003179 0.333638153981798 no 1123 0.25769402735026 270 3834386 SGTC_2208 7283366 200 µM 0.65022805809935 0.33369824844951 no 1124 0.25777245980308 288 898663 SGTC_2091 4-phenylthiadiazole 200 µM 0.646510312950596 0.334618562200999 no 1125 0.258974460209607 285 270010 SGTC_2181 6316240 54.2555 µM 0.644514715122201 0.335112975463843 no 1126 0.259620859309624 291 12779990 SGTC_1819 st053448 58.6 µM 0.644178747762349 0.335196240167571 no 1127 0.259729765200281 319 2857616 SGTC_868 0527-0199 213 µM 0.641287911741769 0.335913026780622 no 1128 0.260667820793992 279 2849450 SGTC_364 0083-0097 67.7 µM 0.638652379121724 0.336567031153908 no 1129 0.26152454921704 285 5207356 SGTC_1474 0330-0125 5.35 µM 0.637963359510215 0.33673809222345 no 1130 0.261748765855709 289 X1474 SGTC_1896 st058441 89 µM 0.637195156285909 0.336928851827814 no 1131 0.261998866173935 285 688759 SGTC_2145 5634607 200 µM 0.634340228312229 0.337638152563141 no 1132 0.262929404141648 303 308662 SGTC_2653 dihydrofissinolide 100 µM 0.633759757031063 0.337782440092275 no 1133 0.263118809995784 289 6857746 SGTC_667 1498-1044 59 µM 0.632335104954453 0.338136666360118 no 1134 0.263583964583622 308 6739982 SGTC_538 2922-0838 53.3 µM 0.632116073393527 0.338191139207374 no 1135 0.263655516457901 281 777039 SGTC_3324 9138759 60.749 µM 0.631894681655142 0.338246202469864 no 1136 0.263727849408327 306 45595710 SGTC_2476 5806916 10.51 µM 0.631596708877072 0.338320317983797 no 1137 0.263825218836905 287 2870194 SGTC_2805 7950783 58.44 µM 0.630462982074065 0.338602369927868 no 1138 0.264195857503093 299 1178958 YDL195W SEC31 SGTC_1665 st014639 11.4 µM 0.629990585457415 0.338719920905143 no 1139 0.264350371932154 295 981133 YIL048W NEO1 SGTC_754 3474-0146 171 µM 0.629567493746855 0.338825216207892 no 1140 0.264488798447308 274 24762078 SGTC_1666 st014829 29 µM 0.628914121416367 0.338987846446258 no 1141 0.2647026402732 292 3858230 SGTC_1892 st058411 7.36 µM 0.628062448126033 0.339199880627297 no 1142 0.264981515837909 295 3934738 SGTC_561 1550-0330 72.9 µM 0.627438963116693 0.339355136921926 no 1143 0.265185767057511 300 6812934 SGTC_447 ml7 120 µM 0.627244366372585 0.339403599758572 no 1144 0.265249532546693 309 4216 Selective myosin light chain kinase inhibitor. SGTC_1016 4226-1401 38 µM 0.626596744156397 0.339564904263557 no 1145 0.26546180153677 298 2901613 SGTC_324 1315-0088 19.6 µM 0.624289800186924 0.340139737874475 no 1146 0.266218640619988 303 6787421 SGTC_636 0kpi-0074 126 µM 0.623756704159001 0.340272625201613 no 1147 0.266393688672644 302 616434 SGTC_2760 etidronate 98.04 µM 0.622657834820935 0.340546608054116 no 1148 0.266754698377535 302 3305 A chelator and antioxidant. SGTC_1833 st055984 71 µM 0.621063081097198 0.340944380236172 no 1149 0.267279059590909 291 676288 SGTC_1961 st076550 68.7 µM 0.617976207823026 0.34171482724933 no 1150 0.268295511070812 301 1579337 SGTC_738 1315-0003 72.4 µM 0.617916253381184 0.34172979771025 no 1151 0.268315272216403 324 6251474 SGTC_861 0443-0273 110 µM 0.617558825646096 0.341819051607471 no 1152 0.268433096551745 308 6149169 SGTC_1199 1638-0010 4.46 µM 0.61696460563702 0.341967454880556 no 1153 0.268629035883867 297 3111136 SGTC_1125 tnp00248 1.32998 µM 0.615562499405322 0.342317720174559 no 1154 0.269091653980843 314 24207736 SGTC_688 0527-0193 473 µM 0.615368535348947 0.342366185736071 no 1155 0.269155682937562 324 4007154 SGTC_167 3672-0051 66.205 µM 0.614044908800671 0.342696987951089 no 1156 0.269592825721213 295 3237971 SGTC_2098 5376439 882.5 nM 0.611358702479404 0.343368698318217 no 1157 0.270481068153798 298 2844116 SGTC_2361 9034121 116 µM 0.608858125835995 0.343994435305528 no 1158 0.271309240935649 322 6496917 SGTC_3172 9105863 49.47 µM 0.608069083531306 0.344191971753356 no 1159 0.271570828062442 298 2348785 SGTC_1123 mangostin 811.285 nM 0.608017520837064 0.344204881935346 no 1160 0.2715879267476 270 5281650 An antioxidant. SGTC_2235 salicylic acid 500 µM 0.606966104667957 0.3444681733544 no 1161 0.271936703330418 291 338 A COX inhibitor and kinase inhibitor. SGTC_2155 5570423 76 µM 0.606056394039954 0.344696040271561 no 1162 0.272238652911971 327 797402 SGTC_789 1309-1135 70.6 µM 0.603247973098588 0.345399856809109 no 1163 0.273171869008336 288 3092424 SGTC_2841 9004761 38.96 µM 0.601345732011725 0.345876880230941 no 1164 0.273804867861812 265 2991039 SGTC_1417 3966-0327 90.4 µM 0.600183838961013 0.346168367640156 no 1165 0.274191861464089 310 651118 SGTC_2080 5212524 12.4 µM 0.599381783226776 0.346369634833839 no 1166 0.274459160987162 314 260183 SGTC_2725 haloperidol 53.21 µM 0.595796517889891 0.347269848074603 no 1167 0.275655585110008 294 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2141 5621638 7.665 µM 0.594375604703171 0.347626859689297 no 1168 0.27613046064373 295 2856238 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.594087728396985 0.347699206543208 no 1169 0.276226719090047 302 75037 A free radical scavenger. SGTC_152 4469-0003 551.229 µM 0.59185165166098 0.348261348795147 no 1170 0.276974965955222 304 697280 SGTC_596 1155-0152 116 µM 0.587061671418343 0.349466655009427 no 1171 0.278581144128692 315 280313 SGTC_2224 6650123 117.647 µM 0.586294163910467 0.349659925025815 no 1172 0.278838926117433 308 2908370 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.58489262336385 0.35001295469608 no 1173 0.279309959469522 292 4174840 SGTC_2417 cerulenin 830 nM 0.584426693613384 0.350130345021427 no 1174 0.279466635923361 304 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_871 0574-0004 149 µM 0.584042381323563 0.35022718272509 no 1175 0.279595899292223 307 9551173 SGTC_491 tetrandrine 80.3 µM 0.583628480151686 0.350331487026456 no 1176 0.27973514732996 321 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_820 1582-0060 59.9 µM 0.583524644279373 0.35035765574036 no 1177 0.279770085927549 306 3848840 SGTC_783 0848-0141 92.7 µM 0.582092012131142 0.350718780121784 no 1178 0.280252352651901 336 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1354 1498-1681 81 µM 0.581250055295655 0.350931075619233 no 1179 0.280535968195173 309 5754243 SGTC_537 1334-0398 209 µM 0.581136165444801 0.350959795990195 no 1180 0.280574342976646 328 5846986 SGTC_203 k066-0004 30.888 µM 0.581094225252054 0.350970372545677 no 1181 0.280588475215809 313 6795412 SGTC_2309 7664088 163.95 µM 0.580647450183938 0.351083048274738 no 1182 0.280739042681518 306 704922 SGTC_1805 st050013 60.3 µM 0.57860583234689 0.351598106479806 no 1183 0.281427584227949 308 4037144 SGTC_2389 9091542 195.52 µM 0.57608144584763 0.352235334081208 no 1184 0.282280065970505 309 3626624 YOL127W RPL25 SGTC_3085 9117376 49.47 µM 0.57594357147301 0.35227014950042 no 1185 0.282326661714339 308 16480349 SGTC_830 4076-0286 57.8 µM 0.575865009951192 0.352289988057572 no 1186 0.282353213861741 308 6866659 SGTC_1224 0823-0416 294 µM 0.573158275646461 0.352973744696493 no 1187 0.283268766246249 317 3598164 SGTC_886 0866-0150 153 µM 0.572602193706781 0.353114277195369 no 1188 0.283457037023933 317 271463 SGTC_2062 5245942 200 µM 0.571215247106565 0.353464872289453 no 1189 0.283926872010192 312 1376160 SGTC_3210 9128157 49.47 µM 0.570362500944283 0.353680492903209 no 1190 0.284215928864912 323 17590849 SGTC_3288 9119690 36.221 µM 0.569997293449412 0.353772851586854 no 1191 0.284339766904142 339 17595618 YKL019W RAM2 SGTC_2731 amoxapine 43.43 µM 0.56879118115058 0.354077930942269 no 1192 0.28474893007074 337 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_343 4130-2827 29.8 µM 0.567598728200707 0.354379647356008 no 1193 0.285153735463681 297 1118244 SGTC_1899 st063254 59.6 µM 0.567224111647002 0.354474452333892 no 1194 0.285280964205424 309 3093813 SGTC_3330 9141424 71.43 µM 0.566023047987937 0.354778468745179 no 1195 0.285689056398015 298 27261020 SGTC_1297 1068-0111 14.1 µM 0.562649009676214 0.35563300867628 no 1196 0.286836956076326 316 767057 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.56258847386292 0.355648347175527 no 1197 0.286857571235504 348 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2517 totarol 10 µM 0.562136550395294 0.355762862442129 no 1198 0.287011493624764 296 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_946 3434-1334 87.4 µM 0.562041951878422 0.355786834906314 no 1199 0.287043718255875 307 4047976 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.561317073745246 0.3559705471427 no 1200 0.287290702133767 313 551469 SGTC_2558 carylophyllene oxide 100 µM 0.557684368076329 0.356891718727492 no 1201 0.288529966926495 328 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.557192656917136 0.357016469783298 no 1202 0.288697903115773 305 2333 A French combination drug. SGTC_2808 7946468 45.46 µM 0.554666899039303 0.357657515487233 no 1203 0.289561260540241 344 2970879 SGTC_16 erodoxin 22.806 µM 0.554526449119511 0.357693173948855 no 1204 0.289609304850393 320 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_419 nsc-638432 893 µM 0.553289796405583 0.35800719804626 no 1205 0.290032493433534 300 368090 SGTC_1262 0737-0114 49.6 µM 0.551334503074646 0.358503903088265 no 1206 0.290702195209824 321 765919 SGTC_1433 4060-0023 7.6 µM 0.548961307242787 0.359107089968255 no 1207 0.291516001790932 310 3840627 SGTC_2267 7931562 200 µM 0.547771311348395 0.359409679437496 no 1208 0.291924469864906 298 934880 SGTC_3312 9133330 71.43 µM 0.545892339221824 0.359887639720355 no 1209 0.29256997231519 340 17617324 SGTC_2922 7999257 32.47 µM 0.544209902401933 0.360315792695411 no 1210 0.293148519166675 326 2988377 SGTC_1490 4089-0339 670 nM 0.544078650807486 0.360349201479962 no 1211 0.293193675521493 337 742542 SGTC_2657 nystatin 74.44 µM 0.540756646248166 0.361195139028452 no 1212 0.294337664287741 314 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_708 3448-5400 146 µM 0.539843444421611 0.361427802072079 no 1213 0.294652501679066 334 3462195 SGTC_1172 0370-0043 85 µM 0.538627949153058 0.361737562106982 no 1214 0.295071799205945 316 376585 SGTC_1232 0279-0259 161 µM 0.538028156591833 0.361890448236036 no 1215 0.295278804998046 335 1560000 SGTC_3258 9138477 49.47 µM 0.537850090434273 0.361935841248914 no 1216 0.295340273652947 339 4970355 SGTC_1128 3448-9350 235 µM 0.537421761127594 0.362045039843326 no 1217 0.295488157563067 286 619386 SGTC_1910 st062352 60.4 µM 0.536748434560093 0.362216720922964 no 1218 0.295720697435719 319 2245730 SGTC_127 0180-0333 59.125 µM 0.536586418535925 0.362258035010374 no 1219 0.295776663793014 289 771601 SGTC_2072 5231554 129 µM 0.53394827864173 0.362930986166154 no 1220 0.296688659292172 316 789545 SGTC_3054 9094397 49.47 µM 0.532974411428991 0.363179512673311 no 1221 0.297025646812385 341 2598354 SGTC_480 am 92016 50 µM 0.531404333378825 0.36358031077744 no 1222 0.297569309633036 355 2129 K+ channel blocker. SGTC_1462 k081-0014 26.5 µM 0.530863146840223 0.363718495575632 no 1223 0.297756808716244 307 3270634 SGTC_467 ro 31-8220 72.8 µM 0.530527829735426 0.363804123243615 no 1224 0.297873009463871 337 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_891 0929-0073 133 µM 0.524958619103627 0.365227286743173 no 1225 0.299805978931972 360 5603632 SGTC_161 4065-0411 162.148 µM 0.524711841886234 0.365290391654541 no 1226 0.299891761981679 340 1906281 YLR208W SEC13 SGTC_3325 9138760 55.175 µM 0.524053552233489 0.365458744765348 no 1227 0.300120646567263 303 43844959 SGTC_2854 9024559 71.43 µM 0.522972990567384 0.365735147267886 no 1228 0.30049652456061 344 3163529 SGTC_673 1082-0474 110 µM 0.513616184865638 0.368131475076796 no 1229 0.30376018082388 333 3098046 SGTC_646 4092-0839 27.3 µM 0.512985973187605 0.368293061435771 no 1230 0.303980566308437 357 877796 SGTC_144 4161-2749 112.381 µM 0.51257183023892 0.368399260432005 no 1231 0.304125431205172 314 797501 YMR168C CEP3 SGTC_110 0850-0284 111.64 µM 0.511970458891752 0.368553488449468 no 1232 0.30433584230152 317 3906265 SGTC_788 1182-0090 188 µM 0.511628844160144 0.368641108579842 no 1233 0.304455397192883 316 5715185 SGTC_356 1634-0012 32.5 µM 0.508076317819519 0.369552693512797 no 1234 0.305699911384341 364 735457 SGTC_515 4092-1064 102 µM 0.50781987992499 0.369618524413573 no 1235 0.305789833358264 369 717353 SGTC_925 2064-1272 59.6 µM 0.505985464757495 0.370089553700826 no 1236 0.306433426785698 350 6815817 SGTC_2183 6420625 130.508 µM 0.503409411317337 0.370751345003704 no 1237 0.307338228067215 343 2897619 SGTC_2569 tetrandrine 100 µM 0.497578166271707 0.372250809486438 no 1238 0.309390698023397 305 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2942 9052777 62.25 µM 0.497505540437694 0.372269496990688 no 1239 0.309416298429574 352 6469503 SGTC_713 1488-1073 324 µM 0.495686337490495 0.372737697908871 no 1240 0.310057863967663 365 3312542 SGTC_918 glabranin 770.725 nM 0.490693526784895 0.374023642025664 no 1241 0.311821612769799 342 124049 Also referred to as licorice root. SGTC_2656 pseudo-anisatin 100 µM 0.487444564486161 0.374861196646646 no 1242 0.312971659434018 364 6708809 A neurotoxin. SGTC_1398 3558-0053 112 µM 0.487020897749416 0.37497045790818 no 1243 0.313121760785411 351 4532369 SGTC_964 1287-0107 19.4 µM 0.48660451702225 0.375077849926797 no 1244 0.313269310948469 343 51516812 YPR165W RHO1 SGTC_123 0083-0120 66.675 µM 0.484613874814264 0.375591405770713 no 1245 0.313975134852228 343 16001701 SGTC_297 0986-0032 24 µM 0.482060152572569 0.376250550615296 no 1246 0.314881607812095 349 2847425 SGTC_1669 st015249 58.4 µM 0.481102760373333 0.376497757633562 no 1247 0.315221733158959 351 722793 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.477764394232003 0.377360148610619 no 1248 0.316408953040303 340 1609 A potent and irreversible inhibitor of serine proteases. SGTC_3021 9087658 49.47 µM 0.477292580719686 0.377482080353314 no 1249 0.31657689669559 353 25237042 SGTC_1667 st014849 34.6 µM 0.476083472975889 0.37779460829483 no 1250 0.317007455386702 327 5348460 SGTC_2014 4013930 200 µM 0.474852060119611 0.378112983861544 no 1251 0.317446211659732 363 64556 SGTC_1737 st035557 69.7 µM 0.474271619244169 0.378263082636828 no 1252 0.317653113593467 347 5716916 SGTC_1008 4106-0037 6 µM 0.473278693950559 0.378519890170864 no 1253 0.318007180328931 357 2905394 SGTC_2916 7875993 68.79 µM 0.472850768921655 0.378630584105148 no 1254 0.318159825235964 369 1299250 SGTC_1954 st077032 68.9 µM 0.471044064948451 0.379098044738213 no 1255 0.318804633903836 369 698907 SGTC_2013 4024628 200 µM 0.47065306002822 0.379199235366475 no 1256 0.318944255017242 367 5230760 SGTC_2191 5911152 200 µM 0.469521471099672 0.379492133019631 no 1257 0.319348470642755 341 2875902 SGTC_185 k048-0037 25.491 µM 0.468890934867856 0.379655369464818 no 1258 0.319573798129893 338 6827589 SGTC_2718 lomofungin 53.02 µM 0.468097587000559 0.379860785889246 no 1259 0.319857402387713 349 5351222 A RNA synthesis inhibitor. SGTC_1596 piperlongumine 63 µM 0.467894658843199 0.379913334209922 no 1260 0.319929961624812 326 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1995 st072814 61.1 µM 0.467850965368292 0.379924648941393 no 1261 0.319945585618006 340 5769371 SGTC_2202 7226349 200 µM 0.466877072576941 0.380176871964943 no 1262 0.320293914849447 328 844334 SGTC_235 0330-0087 5 mM 0.466672472310281 0.380229866720285 no 1263 0.320367113741003 351 46494818 YHR062C RPP1 SGTC_1328 1441-0025 69.2 µM 0.466376647120205 0.380306494171509 no 1264 0.320472962109841 343 4562601 SGTC_223 busulfan 5 mM 0.462088031351828 0.381417898444642 no 1265 0.322009096384605 350 2478 A DNA alkylator. SGTC_387 norethindrone acetate 66.7 µM 0.461669420060813 0.381526435054071 no 1266 0.322159201867364 363 541197 SGTC_2293 7624732 200 µM 0.459226908730263 0.382159909505926 no 1267 0.323035614513883 349 894453 SGTC_1863 st057641 20.1 µM 0.458576621094049 0.382328617300043 no 1268 0.323269114220401 366 3921635 SGTC_3120 9124077 49.47 µM 0.457972853601402 0.382485276111393 no 1269 0.323485972221217 387 18774327 YGL155W CDC43 SGTC_3070 9117005 49.47 µM 0.457867312480625 0.382512662712306 no 1270 0.323523886080009 346 8779016 SGTC_860 0443-0016 25.1 µM 0.45774085537454 0.382545477523629 no 1271 0.323569316064799 343 5337942 SGTC_2781 5567276 71.43 µM 0.455970833709604 0.383004875255765 no 1272 0.324205475869941 361 2853274 SGTC_2840 9008771 71.43 µM 0.454719017384693 0.383329875545098 no 1273 0.324655698750367 316 2992978 SGTC_1036 k216-0215 33.5 µM 0.454621439809289 0.383355212379409 no 1274 0.324690803858997 325 622330 SGTC_710 3448-4187 58 µM 0.452760655937002 0.383838475841181 no 1275 0.325360548618208 343 3946412 SGTC_910 3454-3003 490 µM 0.450626555577805 0.384392944664514 no 1276 0.326129361965294 375 820824 SGTC_1327 1436-0082 2.18 µM 0.448967805181861 0.384824074486287 no 1277 0.326727440723493 358 15992205 SGTC_2564 betulinic acid 100 µM 0.448514372073949 0.384941952195688 no 1278 0.326891008090234 355 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1337 1486-1011 40.3 µM 0.446000554292073 0.385595654856916 no 1279 0.327798422767471 348 X1337 SGTC_2654 protoveratrine a 100 µM 0.443703078827023 0.386193383448357 no 1280 0.328628634606718 376 5702278 A heart drug and vasodilator. SGTC_971 1315-0384 26.7 µM 0.441919330537245 0.386657643313935 no 1281 0.329273790955563 375 6769120 SGTC_698 k064-0052 127 µM 0.441599805608714 0.386740823884785 no 1282 0.32938941234857 372 5088751 SGTC_921 1561-0023 372 µM 0.441469764552473 0.386774678411931 no 1283 0.329436472904707 335 24050882 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.440110990912925 0.387128469253924 no 1284 0.329928360960909 380 5357218 A potent inhibitor of glutathione S-transferases. SGTC_35 0133-0054 64.071 µM 0.439508146946017 0.387285464873997 no 1285 0.330146690076312 355 99677 SGTC_1810 st050138 53 µM 0.438033410281517 0.387669600792018 no 1286 0.330681032147077 400 3444541 SGTC_2956 9076196 2.52 µM 0.437514886034229 0.387804690913103 no 1287 0.330868991389972 372 16423868 SGTC_3326 9140064 16.379 µM 0.4336429154368 0.388813876238906 no 1288 0.332273882849792 366 1868434 SGTC_1703 st026983 48.3 µM 0.43336535658319 0.388886247731598 no 1289 0.332374682162979 363 1104023 SGTC_1221 2958-7315 257 µM 0.432799324510554 0.389033848507452 no 1290 0.332580282061733 358 4562705 SGTC_2723 salbutamol 83.58 µM 0.430681857373094 0.389586149527963 no 1291 0.333349856167761 373 9884233 β2-adrenoceptor agonist SGTC_2925 9010536 32.5 µM 0.429265061211298 0.389955818487207 no 1292 0.333865170046439 323 2994177 SGTC_251 melphalan 456.522 µM 0.428941007168649 0.39004038432694 no 1293 0.333983078329074 388 460612 A DNA alkylator. SGTC_3203 9113543 49.47 µM 0.427701655309087 0.390363856234744 no 1294 0.334434172291939 359 17018012 SGTC_3272 9137413 49.47 µM 0.425924262017426 0.390827889869121 no 1295 0.335081517584979 372 17614870 SGTC_2076 5212012 200 µM 0.423306763430773 0.391511537265887 no 1296 0.33603573015729 370 604802 SGTC_1730 st033808 45.1 µM 0.420946951257555 0.392128168652428 no 1297 0.33689690972643 368 1045166 SGTC_1867 st057372 64 µM 0.4204309795696 0.392263030938958 no 1298 0.337085320350302 358 688837 SGTC_979 1426-2828 121 µM 0.418530978042047 0.39275975597759 no 1299 0.337779471107415 370 747872 SGTC_131 0141-0277 33.849 µM 0.418295325220734 0.392821375836556 no 1300 0.337865603564319 371 1547771 SGTC_656 4090-1979 187 µM 0.418289491467273 0.392822901314138 no 1301 0.337867735942362 383 22330961 SGTC_2260 7964312 200 µM 0.418091698182274 0.392874623572564 no 1302 0.337940037252425 357 231951 SGTC_479 n-linoleoylglycine 10 µM 0.417847853328459 0.392938390759901 no 1303 0.338029180471199 372 6433346 An anti-infammatory. SGTC_2448 5185112 27.17 µM 0.417277645509479 0.393087515427778 no 1304 0.338237668791065 349 5718189 SGTC_745 0469-0705 296 µM 0.415393855785739 0.393580288493781 no 1305 0.338926801906472 400 3486736 SGTC_2245 6637752 200 µM 0.413803819758202 0.393996352421187 no 1306 0.339508893163936 387 681890 SGTC_1558 st069300 45.6 µM 0.413619811807993 0.394044509510523 no 1307 0.339576280809218 373 24208000 SGTC_2378 9074213 121.43 µM 0.413477472311967 0.394081762576569 no 1308 0.33962841209418 359 657714 SGTC_1270 0831-1170 17.3 µM 0.41196678841432 0.394477198139491 no 1309 0.340181883089842 366 6764716 SGTC_2282 7944268 200 µM 0.408218904242149 0.395458710528335 no 1310 0.341556485273992 367 2970414 SGTC_2990 9074105 71.4286 µM 0.407671588998437 0.395602099518809 no 1311 0.341757399231559 395 6502001 SGTC_1217 1183-1422 255 µM 0.405057555186428 0.396287134679156 no 1312 0.342717602476409 372 2849664 SGTC_2688 kanamycin b 96.69 µM 0.404684969129963 0.396384800921284 no 1313 0.34285454607168 360 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.403279286795407 0.396753331904798 no 1314 0.343371388852514 373 23847180 SGTC_2283 7944793 200 µM 0.401260781496695 0.397282689348634 no 1315 0.344114067392511 383 2970533 SGTC_510 ag-490 170 µM 0.401234518092657 0.397289578233347 no 1316 0.34412373458676 358 5328779 SGTC_98 0074-0023 107.663 µM 0.401168012820721 0.39730702269385 no 1317 0.344148214709235 373 3563821 SGTC_2975 9084847 53.72 µM 0.398803296425862 0.397927425600836 no 1318 0.345019073974322 350 27211724 SGTC_1583 clindamycin 39.6 µM 0.398328822683655 0.398051938862379 no 1319 0.345193908557111 387 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2682 pyrogallin 40.03 µM 0.396863018845223 0.39843666639259 no 1320 0.34573423808997 365 822798 An ATP competetive kinase inhibitor. SGTC_2724 maprotiline 69.64 µM 0.396335803998 0.398575067915868 no 1321 0.345928658729277 392 4011 A tricyclic antidepressant. SGTC_82 0054-0107 293.755 µM 0.396016702858577 0.398658842779059 no 1322 0.346046353167033 351 3104697 SGTC_2484 5809818 12.04 µM 0.395596455834976 0.398769178988596 no 1323 0.346201376048172 354 2870548 SGTC_3030 9087619 49.47 µM 0.392735477409175 0.399520545880263 no 1324 0.347257432294424 373 25236973 SGTC_633 0437-0093 97.7 µM 0.391332000096274 0.39988927159133 no 1325 0.347775924192676 382 2831118 SGTC_2178 5812956 200 µM 0.390999398489659 0.399976666767689 no 1326 0.347898840237259 353 5403383 SGTC_816 0325-0417 81.3 µM 0.387947626483445 0.400778790874232 no 1327 0.349027396008454 382 68101 SGTC_119 0121-0043 24.815 µM 0.387515841179924 0.400892314682472 no 1328 0.349187179863121 377 1092378 SGTC_550 4123-0385 25.7 µM 0.38650865382701 0.401157154136691 no 1329 0.349559997397869 370 5731123 SGTC_516 3992-2719 87.3 µM 0.382394567435807 0.402239421758796 no 1330 0.351084359662802 362 5350887 YDR037W KRS1 SGTC_1137 ixabepilone 100 µM 0.381285440885712 0.402531321594985 no 1331 0.351495727839833 361 154225 A novel microtubule stabilizer. SGTC_2937 9044753 11.33 µM 0.380273025768941 0.402797816377109 no 1332 0.351871378260327 376 6465530 YGL099W LSG1 SGTC_2166 5933061 31.504 µM 0.378085605261194 0.403373758120012 no 1333 0.352683500684669 381 2877375 SGTC_2964 9083345 53.42 µM 0.377809809496434 0.403446389286617 no 1334 0.352785942997486 374 17741579 SGTC_1142 3253-1408 9.78 µM 0.376851248072451 0.403698853548574 no 1335 0.353142076587697 396 256655 SGTC_1650 st011916 45.8 µM 0.37617810235835 0.403876169502577 no 1336 0.35339224682135 402 242528 SGTC_4 0960-0234 25.671 µM 0.372148001921066 0.404938166042856 no 1337 0.35489132922205 353 6821112 SGTC_47 0149-0135 24.25 µM 0.368348608523004 0.405940009259445 no 1338 0.356306656032554 356 5239155 SGTC_1293 1000-1278 195 µM 0.367446583597377 0.406177950514563 no 1339 0.356642964659283 406 678847 SGTC_1912 st060209 90.8 µM 0.363507894442274 0.407217325238064 no 1340 0.358112758382835 422 688787 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.363159028803165 0.407309418483353 no 1341 0.358243045775089 367 688664 SGTC_1784 st039334 36.3 µM 0.363081967288177 0.407329761805546 no 1342 0.358271827401663 389 3496984 SGTC_1082 camptothecin 424.86 nM 0.36093065227306 0.407897784048157 no 1343 0.359075644363741 433 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1938 st074717 56.4 µM 0.359705330465895 0.408221398402699 no 1344 0.359533752688511 392 17250979 SGTC_1807 st050092 58.9 µM 0.359280078013682 0.408333724603964 no 1345 0.359692788110277 393 5008496 SGTC_2109 5483026 200 µM 0.358031093217153 0.408663675018404 no 1346 0.360160022404779 408 759335 SGTC_1313 1220-0047 237 µM 0.357863023833364 0.4087080796762 no 1347 0.360222911659018 390 3528706 SGTC_940 3232-1287 54.8 µM 0.355513949242933 0.409328837748021 no 1348 0.361102298300541 408 1585493 YIL048W NEO1 SGTC_457 grayanotoxin iii 135 µM 0.354818387911062 0.409512688014192 no 1349 0.361362825986823 380 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1022 4477-0945 21.3 µM 0.354512043470307 0.409593667069439 no 1350 0.361477589987076 382 4648966 SGTC_2502 avocadyne acetate 18.59 µM 0.35224837402787 0.410192164529574 no 1351 0.362326000756703 356 3952079 SGTC_924 2046-0044 21.3 µM 0.350868120204562 0.410557196215588 no 1352 0.362843644622394 374 3623589 SGTC_2468 5987765 72.9 µM 0.348624973730231 0.411150599766261 no 1353 0.363685438172671 376 26772094 SGTC_1277 0873-0036 22 µM 0.347443744695091 0.411463164753664 no 1354 0.364128987131997 377 5965735 SGTC_1482 3346-2049 8.48 µM 0.346165767336056 0.411801393601949 no 1355 0.364609069916323 388 3826804 SGTC_864 0469-0573 172 µM 0.34554243574546 0.411966388024132 no 1356 0.364843306711317 404 689425 SGTC_177 1327-0068 8.361 µM 0.345230704682501 0.412048908351408 no 1357 0.364960468566938 364 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1927 st060202 13.8 µM 0.34302925147163 0.412631779648464 no 1358 0.365788227145054 393 688887 SGTC_125 0133-0007 11.75 µM 0.342066626845827 0.412886711136753 no 1359 0.366150376035391 430 26541 SGTC_268 camptothecin 39.6153 µM 0.334857030920252 0.414797186487439 no 1360 0.368866468491647 410 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2253 7938677 135.83 µM 0.33204637484389 0.41554253294822 no 1361 0.369927120785463 385 2301972 SGTC_2154 5570129 200 µM 0.330219361613262 0.416027194355069 no 1362 0.370617109093675 424 673366 SGTC_478 N-arachidonylglycine 10 µM 0.327671968832695 0.416703167693729 no 1363 0.371579849951205 398 5283389 SGTC_1050 3232-1156 69.3 µM 0.32586632920575 0.417182459567545 no 1364 0.372262745883225 398 700529 SGTC_786 4544-0069 423 µM 0.324994709211768 0.417413867871557 no 1365 0.372592537987631 388 748821 YLR208W SEC13 SGTC_2424 5537928 59.2 µM 0.323798195919269 0.417731579383906 no 1366 0.373045411063713 420 5382802 SGTC_1458 k015-0034 6.33 µM 0.321786950751294 0.418265748472945 no 1367 0.373807050367429 406 3598957 SGTC_2855 9016525 58.44 µM 0.320869989812496 0.418509335365727 no 1368 0.374154458518669 410 43811474 SGTC_755 1995-0008 37.3 µM 0.32075789831144 0.418539114156397 no 1369 0.374196933540624 388 689533 SGTC_954 1189-0853 2.85 µM 0.317219041586655 0.419479503760242 no 1370 0.375538701198045 376 2828194 SGTC_2355 9061122 103.12 µM 0.316087403313604 0.419780314283441 no 1371 0.375968083834585 417 5302957 SGTC_2645 abamectin 100 µM 0.313998444178901 0.420335721528406 no 1372 0.376761110209185 408 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_645 0845-0943 5.41 µM 0.313825794262246 0.420381632371076 no 1373 0.376826676191388 403 1885106 SGTC_3092 9117248 49.47 µM 0.31234430722965 0.420775631951379 no 1374 0.377389435417248 414 17141857 SGTC_1448 4255-0083 152 µM 0.311401298094024 0.421026465390459 no 1375 0.377747783596407 426 5399660 SGTC_1952 st077036 64.1 µM 0.30867780715213 0.42175107344849 no 1376 0.378783313642316 405 2937007 SGTC_1245 0418-0076 17.2 µM 0.307256177276186 0.422129415665951 no 1377 0.379324194402784 421 6790114 SGTC_2450 5739737 12.93 µM 0.306179520475713 0.422415997109495 no 1378 0.37973398220391 412 2262825 SGTC_1605 st000082 49.1 µM 0.305955005395089 0.422475763075658 no 1379 0.379819452231447 428 1114022 SGTC_2665 lovastatin 100 µM 0.301961036554546 0.423539255540428 no 1380 0.381340882802924 411 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2358 9037157 4 µM 0.301236786055301 0.423732164965315 no 1381 0.381616970296517 394 2388925 SGTC_1075 aripiprazole 15.2 µM 0.30027058140216 0.423989549103724 no 1382 0.381985385550775 390 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1768 st044301 37.178 µM 0.299994083157877 0.424063210550654 no 1383 0.382090834424542 443 3931349 SGTC_1117 retinoic acid 1.10837 µM 0.299320129476423 0.42424276856263 no 1384 0.382347898569636 427 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.298042639129375 0.424583166869107 no 1385 0.382835310143052 440 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1929 genistein trimethyl ether 50.5 µM 0.297842930428436 0.424636386063471 no 1386 0.382911523468595 441 136420 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.296261941324996 0.425057742940282 no 1387 0.383515024193678 453 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_8 0354-0001 70 µM 0.295970951670441 0.425135305312892 no 1388 0.383626132638395 415 4993152 SGTC_2600 tangeritin 87.95 µM 0.295004044727833 0.425393052098614 no 1389 0.383995394948204 408 68077 A bioactive flavone. SGTC_219 mitoxanthrone 164.414 µM 0.294990472430394 0.425396670270714 no 1390 0.384000578966757 413 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1003 4049-0218 100 µM 0.292999801400441 0.425927421365715 no 1391 0.384761151746931 416 295161 SGTC_2753 fluvastatin 17.09 µM 0.292149674194086 0.426154122545769 no 1392 0.385086093986939 411 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2957 9076800 11.52 µM 0.290533099077017 0.426585277637532 no 1393 0.385704216408147 396 16459615 SGTC_2935 9038016 29.96 µM 0.289026694859462 0.426987128152265 no 1394 0.386280474688127 422 6463195 SGTC_2703 st077852 53.4 µM 0.288950368164856 0.427007491189719 no 1395 0.386309679311218 413 6281836 SGTC_2301 7769476 200 µM 0.288244881810561 0.427195715603201 no 1396 0.386579647621402 411 977820 SGTC_2932 9016711 44.54 µM 0.286931661755162 0.42754612804406 no 1397 0.387082323382205 409 7117328 SGTC_2617 dihydrotanshinone i 20.83 µM 0.2866752722514 0.427614548291989 no 1398 0.387180486556435 396 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1384 3089-0840 101 µM 0.286038633396615 0.427784451506425 no 1399 0.387424265987863 393 1069836 SGTC_1904 st060225 78 µM 0.285642983235591 0.42789004752919 no 1400 0.387575789281422 415 66595 SGTC_463 ikarugamyin 104 µM 0.283124517177778 0.428562327751663 no 1401 0.388540694090616 435 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_751 0833-0568 350 µM 0.28185639216947 0.428900920103383 no 1402 0.389026814181411 437 6954252 SGTC_1842 st055362 61.2 µM 0.281078330747127 0.429108690247306 no 1403 0.389325160506331 403 676032 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.279911203108326 0.429420391759806 no 1404 0.389772815913988 412 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_723 4182-0001 115 µM 0.279444335601705 0.429545089092369 no 1405 0.38995192537568 431 744821 YLR208W SEC13 SGTC_2044 5102272 200 µM 0.279078567769216 0.429642788258834 no 1406 0.390092265197069 400 592666 SGTC_811 0416-0114 265 µM 0.27683778633609 0.43024141061789 no 1407 0.390952332665418 435 6612453 SGTC_2241 6772625 37.8075 µM 0.276655702705928 0.430290061128209 no 1408 0.391022244376319 453 2285411 SGTC_2533 agelasine 13.65 µM 0.275566202862821 0.43058118419394 no 1409 0.391440635543827 444 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_3000 9075062 71.4286 µM 0.273978534481176 0.431005489389251 no 1410 0.392050558857957 410 17057871 SGTC_2908 7930301 100 µM 0.270980070119102 0.431807047407222 no 1411 0.393203180357819 397 2223178 SGTC_640 3381-0960 37.1 µM 0.269411774251263 0.432226400785898 no 1412 0.393806413239903 427 1745025 SGTC_424 splitomicin 100 mM 0.269113590362054 0.43230614211334 no 1413 0.393921136253011 428 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2190 6049624 200 µM 0.265047128476022 0.433393882764304 no 1414 0.39548657819262 429 2265554 SGTC_2187 6125751 200 µM 0.260692828235587 0.434559176903295 no 1415 0.397164698557189 423 874498 SGTC_3187 9109394 49.47 µM 0.258771905700265 0.435073433970935 no 1416 0.397905617854583 429 17098090 SGTC_771 0250-0039 27.3 µM 0.258227002784202 0.435219331923421 no 1417 0.398115859616226 459 3005115 SGTC_3194 9111903 49.47 µM 0.257966645490167 0.435289045797856 no 1418 0.398216324612829 445 17087251 SGTC_142 0335-0849 62.6745 µM 0.257689385728262 0.435363287727808 no 1419 0.398323319243906 407 3889043 YPR107C YTH1 SGTC_3134 9127454 49.47 µM 0.25730956017019 0.435464997429977 no 1420 0.398469906456848 451 24262820 SGTC_1838 st055369 84.5 µM 0.256098804108842 0.435789242196511 no 1421 0.398937272691511 384 676036 SGTC_1 0258-0098 57.368 µM 0.255774120190931 0.435876201050073 no 1422 0.39906262921622 398 6790032 YDR047W HEM12 SGTC_1096 rimcazole 32.2 µM 0.254988299878282 0.436086677126236 no 1423 0.399366067978362 453 18528119 A dopamine reuptake inhibitor. SGTC_1492 4158-0558 28.5 µM 0.254630743614797 0.436182451884723 no 1424 0.39950415585169 445 3967268 SGTC_390 dec-rvkr-cmk 16.7 µM 0.254582401882953 0.436195400952845 no 1425 0.399522826345642 415 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2464 5717415 7.67 µM 0.254137026853957 0.436314704643886 no 1426 0.399694849436323 404 5285744 SGTC_414 piperonyl butoxide 100 µM 0.253207997070762 0.436563584745244 no 1427 0.400053743536431 443 5794 A potent inhibitor of cytochrome P450. SGTC_1434 4073-0095 163 µM 0.253130072988436 0.436584461164589 no 1428 0.400083850281509 440 24133745 SGTC_1749 st037932 54.2 µM 0.251941515005577 0.436902906214214 no 1429 0.40054313500036 440 594497 SGTC_2156 5649887 115 µM 0.251099641806027 0.437128490303816 no 1430 0.400868536416572 439 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2830 7992007 71.43 µM 0.251019260802796 0.437150029861613 no 1431 0.400899608939221 420 1952075 SGTC_1334 1486-0610 236 µM 0.250768026684938 0.43721735383255 no 1432 0.400996731422772 415 3742339 SGTC_1627 st003713 25.6 µM 0.249816234767387 0.437472424882615 no 1433 0.401364732105336 411 16195070 YER133W GLC7 SGTC_2700 st077718 96.8 µM 0.246547783723598 0.438348535438105 no 1434 0.402629109825097 417 904970 SGTC_1021 4476-0760 85.3 µM 0.243706039871534 0.439110512617887 no 1435 0.403729247625707 421 746768 SGTC_2507 purpurin 79.67 µM 0.243102813051203 0.439272289289651 no 1436 0.403962876038634 421 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_259 usnic acid 108.925 µM 0.241168812180388 0.439791028493904 no 1437 0.404712140922103 458 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2312 7706453 155.7 µM 0.240079243309365 0.440083319082762 no 1438 0.405134412570972 434 976098 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.239917645500348 0.440126672517496 no 1439 0.405197050590036 432 6708514 SGTC_412 gemfibrozil 100 µM 0.238257767174167 0.440572025877727 no 1440 0.40584058755827 446 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1491 4138-0063 26.5 µM 0.236631392165563 0.441008463062662 no 1441 0.406471382158402 450 23883227 SGTC_29 0299-0004 12.984 µM 0.236580411450107 0.441022144881478 no 1442 0.406491159120368 460 16871 A napthoquinone isolated from Swertia calycina. SGTC_678 1218-2179 85.9 µM 0.235964153793981 0.441187537013821 no 1443 0.40673024296508 472 6820081 YOR116C RPO31 SGTC_431 k089-0097 107 µM 0.235664884222368 0.441267859121693 no 1444 0.40684636039014 431 5499420 SGTC_3119 9125183 49.47 µM 0.235553026231019 0.441297881737305 no 1445 0.406889763704625 451 22695334 SGTC_642 0335-0876 158 µM 0.235101446038708 0.441419089009306 no 1446 0.407064998186749 456 6812350 SGTC_2807 7945238 51.95 µM 0.234977365298653 0.441452394106376 no 1447 0.407113150644871 462 17148797 SGTC_882 0843-0131 351 µM 0.234929580212791 0.441465220437236 no 1448 0.407131695149135 444 5425421 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.22942766107794 0.44294243629805 no 1449 0.409268269514372 426 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1374 2889-5571 141 µM 0.228321041867675 0.443239650122943 no 1450 0.409698333746294 420 2853281 SGTC_838 0109-0203 71.4 µM 0.226182632703442 0.443814070606576 no 1451 0.410529688860951 427 759422 SGTC_1424 4048-1941 275 µM 0.224982849441001 0.444136408737432 no 1452 0.41099630821059 473 X1424 SGTC_3208 9114115 49.47 µM 0.222431729770609 0.444821924391269 no 1453 0.411988906819499 457 650895 SGTC_970 1315-0089 19.5 µM 0.222306881250382 0.444855476900155 no 1454 0.412037497831542 443 6811083 YLR033W RSC58 SGTC_2666 tannic acid 100 µM 0.222053851119116 0.444923478883459 no 1455 0.412135981229394 450 16134267 A thiamine antagonist. SGTC_1104 tacrolimus 29.8 µM 0.221459708203261 0.445083161478316 no 1456 0.412367252952018 436 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1704 st028805 70.8 µM 0.220981427814593 0.445211711190463 no 1457 0.412553446988262 424 2876101 SGTC_194 1486-1323 56.904 µM 0.217777918886272 0.446072881513277 no 1458 0.413801074913138 447 5178754 SGTC_369 0957-0393 4.5 µM 0.215802359342469 0.446604080413521 no 1459 0.414570904581255 433 6997992 SGTC_1750 st081859 2.357 µM 0.215303618767645 0.446738199604613 no 1460 0.414765304209907 456 5291695 SGTC_672 1441-0018 53.7 µM 0.215212021296004 0.446762832269198 no 1461 0.414801009439706 422 251141 SGTC_1444 4112-3581 28 µM 0.214870276001958 0.446854737242415 no 1462 0.41493422996229 439 2877249 SGTC_834 0312-0008 75.7 µM 0.21385968503625 0.447126530411754 no 1463 0.415328239772125 433 6385573 YIL048W NEO1 SGTC_1571 st070080 73.4 µM 0.21306066633708 0.447341439909353 no 1464 0.415639821965571 431 4315245 SGTC_2836 9010338 19.48 µM 0.21298058941633 0.447362978795445 no 1465 0.415671051374811 441 2994051 SGTC_2903 5923464 63.88 µM 0.211310096378691 0.447812339058352 no 1466 0.416322652514935 458 2876576 SGTC_1331 1472-0049 76.2 µM 0.210914488734878 0.447918766786139 no 1467 0.416476999031483 476 24051409 SGTC_333 3486-0131 40.1 µM 0.208299025244955 0.448622481737066 no 1468 0.41749774634834 465 6744690 SGTC_2793 7325131 81.82 µM 0.20788835881608 0.448732990129023 no 1469 0.417658069462784 448 4176441 SGTC_2445 5742597 35.57 µM 0.206722225201553 0.449046812820368 no 1470 0.418113399550342 434 1774255 SGTC_12 0849-0099 9.267 µM 0.205888088030944 0.449271310243565 no 1471 0.418439165244116 463 6071388 SGTC_181 1447-1644 8.07 µM 0.205814376914592 0.449291149436168 no 1472 0.418467955233097 454 534600 SGTC_2030 5175110 200 µM 0.205554174580914 0.449361183362637 no 1473 0.418569588202883 465 2831986 SGTC_3046 9092212 49.47 µM 0.204489670740429 0.449647712892565 no 1474 0.418985431508157 454 25236637 SGTC_2452 5863136 48.41 µM 0.203437452624153 0.449930961311231 no 1475 0.419396564425472 453 2184096 SGTC_805 3852-0218 479 µM 0.203146258726749 0.450009352813998 no 1476 0.419510358111091 457 6615355 SGTC_2133 5320837 200 µM 0.202902033548131 0.450075101502266 no 1477 0.419605802400983 446 2841355 SGTC_2568 diosmetin 100 µM 0.201484180809977 0.450456833459249 no 1478 0.420159998841721 476 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1038 k292-0204 154 µM 0.199906526807295 0.450881642963487 no 1479 0.420776842911599 461 4454212 SGTC_3159 9100096 49.47 µM 0.198705719693776 0.451205017932965 no 1480 0.421246474788889 429 25236875 SGTC_2038 4100038 30.985 µM 0.198405189030978 0.4512859553186 no 1481 0.421364028943415 456 3596803 SGTC_2641 levomentholum 100 µM 0.19779567554095 0.451450112599166 no 1482 0.421602464874841 477 16666 SGTC_1467 k284-1082 293 µM 0.196801738120044 0.451717822689019 no 1483 0.421991345447459 445 3334705 SGTC_2455 5377712 9.75 µM 0.192402607159357 0.452902959841278 no 1484 0.423713425168713 418 2243908 SGTC_3226 9131256 49.47 µM 0.191335644802529 0.453190465870395 no 1485 0.424131318207448 438 17178073 SGTC_1633 st005664 67.9 µM 0.189220864464246 0.453760391617388 no 1486 0.424959857786133 440 2063822 SGTC_17 0960-0276 49.807 µM 0.187746545466458 0.454157771731547 no 1487 0.425537670499975 459 6821114 SGTC_347 4534-1311 26.2 µM 0.186927824578015 0.45437846525672 no 1488 0.425858611421025 448 2862016 SGTC_2434 5670830 169.91 µM 0.186317456119745 0.454543004692352 no 1489 0.426097909568065 466 1549830 SGTC_1881 5652484 16 µM 0.185182245030591 0.454849048752461 no 1490 0.426543047327363 465 2255129 SGTC_2576 guaiol 23.12 µM 0.185107156145443 0.454869293077584 no 1491 0.42657249440676 430 227829 SGTC_3007 9078383 71.4286 µM 0.1827715277458 0.455499048009335 no 1492 0.427488644915684 436 6496995 SGTC_2136 5328288 199.296 µM 0.181514506502161 0.455838024741348 no 1493 0.427981873867978 452 262395 SGTC_2511 berberine 10.47 µM 0.181301043135529 0.455895591896473 no 1494 0.428065643646783 435 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2346 9031566 143.75 µM 0.181262087933736 0.455906097499908 no 1495 0.428080931250381 463 4771086 SGTC_2528 xanthyletin 44.79 µM 0.181094714412972 0.455951235848961 no 1496 0.428146616646879 463 65188 An natural product with antifungal activity of unknown mechanism. SGTC_877 0771-0151 33.1 µM 0.179712227866712 0.456324095248232 no 1497 0.428689246645468 477 6166523 SGTC_3215 9129942 49.47 µM 0.178161477701159 0.45674238143761 no 1498 0.429298081004201 490 17682944 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.177812108642052 0.456836623915308 no 1499 0.429435268785264 466 279621 SGTC_2281 7943571 200 µM 0.177168861903764 0.457010146389298 no 1500 0.429687876662585 477 1244024 SGTC_827 3253-0474 693 µM 0.17391134912281 0.457889019402691 no 1501 0.430967566619605 447 5402065 SGTC_2508 celastrol 40.54 µM 0.173287964037675 0.45805723155432 no 1502 0.431212541940081 447 122724 Celastrol is a natural product and antioxidant. SGTC_2677 mitomycin C 100 µM 0.170595148816438 0.45878393776472 no 1503 0.432271056345934 460 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1843 st055809 45.5 µM 0.169975637842825 0.458951143890198 no 1504 0.432514648008237 450 16413835 SGTC_703 3875-0075 71.8 µM 0.169327025665528 0.459126212217526 no 1505 0.432769709747606 492 2850814 SGTC_1828 st055811 49 µM 0.168443445674195 0.459364713968059 no 1506 0.433117215823898 490 5877589 SGTC_2217 6934799 96.0675 µM 0.167640983489701 0.45958133253931 no 1507 0.433432863637945 472 675606 SGTC_1856 st057054 55.7 µM 0.165090839512613 0.460269803884915 no 1508 0.434436241544509 479 1266018 SGTC_2880 9042983 58.44 µM 0.163625328678238 0.460665507037961 no 1509 0.43501305201752 461 6464714 SGTC_2643 anethole 100 µM 0.163018096924675 0.460829477357619 no 1510 0.435252092992504 489 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2796 7949634 45.45 µM 0.162555219363799 0.46095447230146 no 1511 0.435434323841029 454 2971588 SGTC_2674 ligustilide 100 µM 0.162194357973698 0.461051921588246 no 1512 0.435576401329067 476 5319022 A signalling regulator. SGTC_3022 9087993 49.47 µM 0.161998563959185 0.4611047960185 no 1513 0.435653492363906 492 17173644 SGTC_1562 morin hydrate 59.1 µM 0.161485635439781 0.461243316295253 no 1514 0.435855462066658 456 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2053 5265679 138 µM 0.161075102703996 0.461354187194784 no 1515 0.436017124667589 473 764595 SGTC_104 0074-0074 590.992 µM 0.160863009148968 0.46141146761239 no 1516 0.436100648617927 458 3943124 SGTC_2118 5526350 200 µM 0.160571215120446 0.461490274161846 no 1517 0.436215563838016 468 743594 SGTC_397 arbidol 50 µM 0.160087775458784 0.461620842914237 no 1518 0.436405965375239 469 131410 A RNA synthesis inhibitor. SGTC_2243 6634756 200 µM 0.159561739234918 0.461762920965773 no 1519 0.436613160204768 413 885676 SGTC_2087 5276107 200 µM 0.158967540492739 0.461923415020391 no 1520 0.436847223760903 488 144405 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.15754037117009 0.462308921075674 no 1521 0.437409496758951 456 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3192 9110362 49.47 µM 0.155929828266421 0.462744002391249 no 1522 0.438044166660733 471 16649480 SGTC_2882 9058044 58.44 µM 0.154653944546848 0.463088708620976 no 1523 0.438547069981555 455 18076804 SGTC_1836 st055642 81 µM 0.153151455736348 0.463494672396539 no 1524 0.439139419328272 495 8571 SGTC_3225 9130819 49.47 µM 0.152952117778749 0.463548535223938 no 1525 0.439218017678059 481 4547121 SGTC_1945 st075991 56.6 µM 0.15287247343849 0.463570055995274 no 1526 0.439249421869131 420 1084980 SGTC_260 nsc-65238 3.989 µM 0.151813456612223 0.463856224026429 no 1527 0.439667034159024 452 3246252 SGTC_2642 cholecalciferol 100 µM 0.151056619183764 0.464060748463529 no 1528 0.439965526307985 466 9821465 A vitamin D precursor, similar to steriods. SGTC_766 1391-0721 126 µM 0.14853662124878 0.464741809844548 no 1529 0.440959643456612 484 1020919 YIL115C NUP159 SGTC_3088 9117578 49.47 µM 0.148126431193937 0.464852678734932 no 1530 0.441121495230404 490 678341 SGTC_2269 7935389 174.42 µM 0.147794241575233 0.464942467149868 no 1531 0.441252576994025 466 97605 SGTC_2837 9008476 45.46 µM 0.147154179326818 0.465115476305467 no 1532 0.441505163190716 488 2992805 SGTC_1453 4237-0541 195 µM 0.14661239304655 0.465261926571029 no 1533 0.441718985579567 460 739892 SGTC_246 cycloheximide 667 µM 0.144393919690159 0.465861651037032 no 1534 0.442594708940307 476 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2900 5328528 85.29 µM 0.144251288770553 0.465900211414154 no 1535 0.442651020918605 491 795359 SGTC_3302 9125395 16.351 µM 0.143318535240003 0.466152389913505 no 1536 0.443019308969149 470 17599668 SGTC_3263 9137018 49.47 µM 0.142919893488227 0.466260170530271 no 1537 0.443176723563624 498 43844957 SGTC_1695 st026914 34.495 µM 0.142354811657711 0.466412955725016 no 1538 0.44339987693521 463 3289191 SGTC_1515 3460-0031 42.1 µM 0.142050980039059 0.466495106888934 no 1539 0.44351986884153 470 2876596 SGTC_1942 st076330 65.2 µM 0.141633087664586 0.46660810057075 no 1540 0.443684915101889 489 24208414 SGTC_1420 4'-methoxyflavone 42 µM 0.141474391840452 0.466651010950097 no 1541 0.443747594452019 483 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2618 avocadyne 43.43 µM 0.139429069153793 0.467204088199946 no 1542 0.444555551420801 480 3015189 SGTC_1163 k060-0048 49.9 µM 0.138297557857894 0.467510088297702 no 1543 0.445002627756183 453 6809982 SGTC_826 1683-5028 118 µM 0.137491901573029 0.467727977554901 no 1544 0.445320996781836 469 722377 SGTC_2784 7567673 72.73 µM 0.135791288174674 0.468187939092365 no 1545 0.445993139148569 503 3471247 SGTC_2874 9043904 71.43 µM 0.135614675457891 0.468235709628956 no 1546 0.446062951650915 465 4463428 SGTC_547 1120-0019 610 nM 0.133068075239779 0.468924569303911 no 1547 0.447069771421054 486 3676939 SGTC_1990 st072050 59.8 µM 0.13177887224439 0.469273336501462 no 1548 0.447579599150852 504 17233948 SGTC_544 k015-0020 52.4 µM 0.130728160939464 0.469557602157805 no 1549 0.447995177152319 490 3008304 SGTC_1557 sumaresinolic acid 42.3 µM 0.128999556943494 0.47002530261239 no 1550 0.448678999703904 460 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2870 9038528 12.99 µM 0.128608557304742 0.470131099349542 no 1551 0.448833697398344 485 6463316 SGTC_523 1934-0222 13.7 µM 0.128450538377728 0.470173856731682 no 1552 0.448896219264904 505 1361595 SGTC_2915 7971052 15.16 µM 0.128425624774111 0.470180597983832 no 1553 0.448906076712599 501 5741558 SGTC_737 1950-0117 57.9 µM 0.127149692813658 0.470525857658748 no 1554 0.449410960711203 467 5393513 SGTC_2222 6885208 172.143 µM 0.126693954060512 0.470649183265637 no 1555 0.449591315618931 471 609514 SGTC_1415 3966-0071 78.1 µM 0.126525065690191 0.47069488617485 no 1556 0.449658154465545 491 2893185 SGTC_856 0433-0016 11.3 µM 0.125675716578747 0.470924734514827 no 1557 0.449994312398403 478 3911780 SGTC_1957 st077035 62.4 µM 0.124956651711671 0.471119333292982 no 1558 0.450278934102555 502 705593 SGTC_2284 7945075 39.21 µM 0.124623067998506 0.471209612587376 no 1559 0.450410982572998 490 1245402 SGTC_2150 5556613 200 µM 0.123645695392882 0.471474131931148 no 1560 0.450797905188034 470 743190 SGTC_2776 terbinafine 19.92 µM 0.122049924530669 0.471906043611966 no 1561 0.451429739861777 491 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2761 levamisole 97.89 µM 0.12060864290055 0.472296169616187 no 1562 0.452000511388712 489 26879 An alkaline phosphatase inhibitor. SGTC_2116 5511452 16.8835 µM 0.12052893187583 0.472317746569513 no 1563 0.452032081188297 491 870744 SGTC_655 k060-0012 42 µM 0.119845695533409 0.472502694935582 no 1564 0.452302691490822 495 5994525 SGTC_11 0438-0307 1.3 µM 0.115766885554127 0.473606928611678 no 1565 0.453918647756318 490 4011476 SGTC_1183 1254-0324 198 µM 0.114648088117689 0.473909850262739 no 1566 0.45436203108728 478 5799357 SGTC_606 k015-0008 38.6 µM 0.114617356360723 0.473918171298639 no 1567 0.45437421099499 496 1970475 SGTC_385 1494-0393 12.4 µM 0.113310199688283 0.474272112010818 no 1568 0.454892315569622 489 3090647 SGTC_3267 9137951 49.47 µM 0.112952848961413 0.474368875933145 no 1569 0.455033968486522 503 16643986 SGTC_1487 3970-0795 2.82 µM 0.112317254023965 0.474540986939137 no 1570 0.455285930816569 474 3765103 SGTC_2788 5282734 71.43 µM 0.110739418425372 0.474968265173778 no 1571 0.455911493408565 486 743706 SGTC_3347 9188721 44.724 µM 0.108546585237309 0.475562132599691 no 1572 0.456781064554852 509 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2103 5378138 10 µM 0.10721184411749 0.475923636498306 no 1573 0.457310459671396 495 244142 SGTC_1258 0671-0043 57.1 µM 0.106435637416522 0.476133874974187 no 1574 0.457618359543061 485 4298767 SGTC_1299 1079-1439 3.74 µM 0.106012966840597 0.476248359671627 no 1575 0.457786032056726 473 323161 SGTC_2785 7756463 72.73 µM 0.104487643741832 0.476661525447048 no 1576 0.458391186735161 517 2201551 SGTC_1672 st016598 6.51 µM 0.101757729995176 0.477401042228697 no 1577 0.45947448900078 499 4665860 YNL267W PIK1 SGTC_1233 0325-0408 14.2 µM 0.101199751470193 0.477552204829162 no 1578 0.459695947002383 489 12874 SGTC_726 3448-4391 34.2 µM 0.101178421403939 0.47755798344604 no 1579 0.459704413013793 504 1356692 SGTC_2197 6588183 93.1375 µM 0.0994056360940303 0.478038272457512 no 1580 0.460408103987362 486 884136 SGTC_52 0329-0193 875 nM 0.0990164941202034 0.478143704415106 no 1581 0.46056258702339 506 3739292 SGTC_3217 9129673 49.47 µM 0.0987219030637291 0.47822352029178 no 1582 0.460679538842717 470 17248312 SGTC_2216 7189485 200 µM 0.0983675002600049 0.478319542593639 no 1583 0.46082024026355 499 731273 SGTC_2231 micatex 6.853 µM 0.0965007870297153 0.478825332657297 no 1584 0.461561424442759 494 20737 An antifungal of unknown mechanism. SGTC_857 0438-0306 1.35 µM 0.0936280571388315 0.479603771489166 no 1585 0.462702310567709 499 4686136 SGTC_948 3448-0295 75.3 µM 0.0935363952063782 0.479628610904981 no 1586 0.462738718614344 476 678569 SGTC_3110 9122132 49.47 µM 0.0935037940711665 0.479637445487458 no 1587 0.46275166783458 480 918317 SGTC_342 k048-0088 23.3 µM 0.0913803942714451 0.480212886998735 no 1588 0.463595169834031 507 6820570 SGTC_2552 juarezic acid 87.02 µM 0.0902076712130259 0.48053071279282 no 1589 0.464061094218431 473 1549512 SGTC_2941 9056145 11.23 µM 0.0898055689412892 0.480639691486862 no 1590 0.464220861350076 515 2119517 SGTC_1548 st061468 90.8 µM 0.0897866713751431 0.480644813184909 no 1591 0.464228370054471 514 390799 SGTC_1547 harmine 94.2 µM 0.0874897232247412 0.48126736529972 no 1592 0.46514112689358 507 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3234 9132280 49.47 µM 0.086242763400848 0.481605353620061 no 1593 0.465636718521767 468 17612295 SGTC_1785 bathophenanthroline 24 µM 0.0857020165459901 0.48175192711883 no 1594 0.46585164952842 510 72812 An iron chelator. SGTC_1289 0976-0073 69.1 µM 0.0838106938906393 0.482264603610374 no 1595 0.466603472720873 507 3391136 SGTC_2395 5646831 180.19 µM 0.0823747344764565 0.482653865465936 no 1596 0.467174363361062 507 6808628 SGTC_3154 9100113 49.47 µM 0.0821278666757441 0.482720788405436 no 1597 0.467272516784485 491 25237525 SGTC_2307 7538926 6.34 µM 0.0818366259197433 0.482799740953873 no 1598 0.467388315234988 508 96582 SGTC_34 0469-0683 81.75 µM 0.0796272977445682 0.483398690171047 no 1599 0.468266841842912 502 3690923 SGTC_760 0568-0725 82.9 µM 0.0794263426767711 0.483453171000823 no 1600 0.468346758199682 526 3916171 SGTC_3156 9099931 49.47 µM 0.079380056352928 0.48346571970717 no 1601 0.468365165651426 498 18111053 SGTC_1852 st056254 31.4 µM 0.0787104143573318 0.483647268479938 no 1602 0.468631480861702 512 442583 SGTC_880 0833-0487 87.2 µM 0.0783309968355506 0.483750135079006 no 1603 0.468782380647992 495 76075 SGTC_68 0986-0284 82.829 µM 0.0776160939364435 0.483943960452584 no 1604 0.469066719946116 516 423278 YIL048W NEO1 SGTC_1475 4092-1048 11.7 µM 0.0775924200393947 0.483950379014496 no 1605 0.469076136067934 497 2881759 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0751658975184442 0.484608289293677 no 1606 0.470041358703341 507 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2862 9027634 71.43 µM 0.0750897312828157 0.48462894115969 no 1607 0.470071659003989 508 5012562 SGTC_451 chloral hydrate 100 µM 0.0735450829781289 0.485047769021722 no 1608 0.470686185077368 519 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1504 k297-0033 30 µM 0.0731863212100156 0.485145048833793 no 1609 0.47082892564468 489 4388117 SGTC_1365 1672-3266 55.4 µM 0.0726086122155986 0.485301698993098 no 1610 0.471058786627729 507 6415873 SGTC_391 gliotoxin 8.33 µM 0.0721005600322377 0.485439463057098 no 1611 0.471260940273011 511 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_378 3970-0959 8.33 µM 0.071332953997172 0.485647611358548 no 1612 0.471566384262734 515 6615653 SGTC_2611 pyromycin 23.93 µM 0.0711508407242126 0.485696994777757 no 1613 0.471638852809776 509 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2623 humulene 100 µM 0.070737958316251 0.485808956374179 no 1614 0.471803155061804 500 6187145 An anti-inflammatory. SGTC_2239 6685329 187.64 µM 0.0706153351996719 0.485842208381887 no 1615 0.47185195257881 455 805680 SGTC_1034 k072-0165 12.7 µM 0.0700605542069768 0.485992650915026 no 1616 0.472072731350907 517 5835461 SGTC_1053 3366-3204 134 µM 0.069998528924009 0.486009470722786 no 1617 0.472097415257837 505 3632071 YPR165W RHO1 SGTC_3071 9117417 49.47 µM 0.0699109662209959 0.486033215724643 no 1618 0.47213226235281 522 45595590 YGL055W OLE1 SGTC_3298 9116858 71.43 µM 0.0678228309833796 0.486599484711523 no 1619 0.472963334555004 517 2506942 SGTC_958 1222-0007 33 µM 0.0663824842311619 0.486990099604288 no 1620 0.473536657499636 511 7312461 SGTC_486 niguldipine 82 µM 0.065552145483341 0.487215289048714 no 1621 0.473867194743472 501 1236 A calcium channel blocker. SGTC_1651 st011928 86.1 µM 0.0650088209713468 0.487362641898426 no 1622 0.474083488496873 506 720198 SGTC_1195 1502-0147 41.1 µM 0.0649227865142379 0.487385975115309 no 1623 0.474117738925138 522 817940 SGTC_1305 1181-0477 144 µM 0.0645805591892142 0.487478790266093 no 1624 0.474253981955874 517 6252086 SGTC_2878 9043973 25.97 µM 0.0640528010908898 0.487621924370892 no 1625 0.474464091948746 488 6465167 SGTC_1326 1431-2094 10.8 µM 0.0637683850734382 0.48769906194913 no 1626 0.474577326030722 508 616278 SGTC_2326 6164455 177.58 µM 0.0631161741181463 0.48787595236094 no 1627 0.474836997447041 502 2888790 SGTC_1162 k048-0130 20.1 µM 0.062457652279633 0.488054556808519 no 1628 0.475099192324725 505 6797406 SGTC_1700 st030840 7.9285 µM 0.0616663591499591 0.488269174682587 no 1629 0.475414265235487 501 5499307 SGTC_1387 3342-1166 1.8 µM 0.0571770910494764 0.489486835464372 no 1630 0.477202063496933 519 3418228 SGTC_458 nppb 133 µM 0.0569505275658355 0.489548290817672 no 1631 0.477292302208709 515 4549 A chloride channel blocker. SGTC_141 0443-0274 32.331 µM 0.0563299663508901 0.489716619336403 no 1632 0.477539473515505 518 1627241 SGTC_572 0960-0087 17.7 µM 0.056085046578691 0.489783054839175 no 1633 0.477637028144543 522 6796365 SGTC_1743 st037606 46.3785 µM 0.0559287588733005 0.489825448674941 no 1634 0.477699280206164 519 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2092 5303694 80.6725 µM 0.0551215916436281 0.490044398714603 no 1635 0.478020797324628 509 1963699 SGTC_647 0140-0236 81 µM 0.0519573221193661 0.490902758377968 no 1636 0.479281349733991 516 990837 SGTC_536 3852-0578 10.6 µM 0.0503312520721739 0.491343873010145 no 1637 0.479929209884857 499 2869208 SGTC_1229 0139-0193 12.2 µM 0.0499144628726707 0.491456939861974 no 1638 0.480095275982281 503 3090752 SGTC_197 4544-0043 41.561 µM 0.0463510761215061 0.492423644883912 no 1639 0.481515215083784 511 896523 SGTC_1761 st044296 37 µM 0.0435848654955933 0.493174116347155 no 1640 0.482617657909189 518 1826700 SGTC_1196 1588-0294 184 µM 0.0432667567509075 0.493260420678632 no 1641 0.482744445332368 525 6144269 SGTC_3005 9076496 71.4286 µM 0.0422511003764587 0.493535974907481 no 1642 0.483149263346263 528 21368410 SGTC_86 0417-1630 471.922 µM 0.0421667262230379 0.493558866308683 no 1643 0.483182893792206 522 3634867 SGTC_854 0422-0053 192 µM 0.0416404269096956 0.493701656113301 no 1644 0.483392672580845 533 3596728 SGTC_3166 9102297 49.47 µM 0.0415463536738272 0.493727179125872 no 1645 0.48343016992265 524 25237072 SGTC_1969 st069479 40.1 µM 0.0415453404364306 0.493727454027482 no 1646 0.483430573797182 533 3895485 SGTC_2982 9019404 25.97 µM 0.0412886715205291 0.493797091010152 no 1647 0.48353288209367 496 22333232 SGTC_2696 st077691 74.316 µM 0.0403059714795441 0.494063709619652 no 1648 0.48392459654857 532 757133 SGTC_2489 cantharidin 73.42 µM 0.040100578464908 0.494119435610118 no 1649 0.484006470312902 535 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1109 tnp00067 928.257 nM 0.0395407667765609 0.494271320910987 no 1650 0.484229625864065 532 676295 SGTC_2439 5492030 7.2 µM 0.0382539917506961 0.494620445372469 no 1651 0.484742586588708 529 5722370 SGTC_440 fluspirilene 35.1 µM 0.0370130811916084 0.494957129911599 no 1652 0.485237287802664 526 3396 An atypical antipsychotic. SGTC_1086 cerivastatin 2.18 µM 0.0364131498414838 0.495119904920227 no 1653 0.485476464538134 527 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_285 1486-1325 46 µM 0.0363872209825423 0.495126940027399 no 1654 0.485486801805676 526 22310230 SGTC_2523 spermine 47.74 µM 0.036190575389671 0.495180294635054 no 1655 0.485565200408864 521 1103 A DNA binding polyamine. SGTC_614 0462-0418 107 µM 0.0352591423236134 0.495433015645642 no 1656 0.485936551380014 518 5188303 SGTC_898 1000-0849 28.3 µM 0.0346775820202514 0.495590808389607 no 1657 0.486168418565002 536 6751807 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.0338089104586259 0.495826503314603 no 1658 0.486514765245251 532 688664 SGTC_1991 st073000 8.92 µM 0.0328928054685951 0.496075069833998 no 1659 0.486880035048699 530 4301969 YIL048W NEO1 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.0327447980798469 0.496115228784304 no 1660 0.486939049663723 523 4330530 SGTC_2820 7989630 71.43 µM 0.029988908319338 0.496862993072078 no 1661 0.488037949536225 534 2984098 SGTC_3227 9130768 49.47 µM 0.0299754373208684 0.496866648229921 no 1662 0.488043321272122 534 17720899 SGTC_1682 st012968 530 nM 0.0290436958738243 0.497119463226259 no 1663 0.488414870505858 520 24207270 SGTC_1647 st011722 22.4 µM 0.0283034342500305 0.497320323683092 no 1664 0.488710070781566 525 2854783 SGTC_1725 st036284 20.55 µM 0.0280929059253521 0.497377447958613 no 1665 0.488794026046751 502 707914 SGTC_2303 7774051 200 µM 0.0279879179232571 0.497405935183851 no 1666 0.488835893736923 535 2953184 SGTC_960 1222-0186 7.7 µM 0.0260134379275022 0.497941688765518 no 1667 0.489623310081185 534 3126296 SGTC_1144 3486-0183 12.5 µM 0.0247918704166465 0.498273149687956 no 1668 0.490110487767365 542 6744069 SGTC_1461 k072-0203 53.8 µM 0.0244173114976834 0.498374782997889 no 1669 0.490259869931996 529 5418714 SGTC_73 0327-0325 16.231 µM 0.0223165686990819 0.498944803080111 no 1670 0.491097716131528 541 53298 SGTC_1908 st060353 56.5 µM 0.0221454151979089 0.498991244350897 no 1671 0.491165979628927 532 4227716 SGTC_2853 9015042 58.44 µM 0.0219885560044836 0.49903380697617 no 1672 0.491228542158865 537 6457456 SGTC_3140 9094243 49.47 µM 0.0214213724895436 0.499187708272761 no 1673 0.491454762347629 541 19291112 SGTC_2406 ethylparaben 405.7 µM 0.0201150624067913 0.499542166837819 no 1674 0.491975792256786 508 8434 A possible steroid mimic. SGTC_1246 0422-0085 105 µM 0.019673498345742 0.499661982408821 no 1675 0.492151915972032 543 264295 SGTC_344 k064-0035 6.43 µM 0.0184277807643912 0.5 no 1676 0.492648795178962 536 5088750 SGTC_3334 9142812 21.919 µM 0.0182606325565406 0.49995464538506 no 1677 0.492715466447374 532 45283678 SGTC_704 1310-0270 142 µM 0.0181988645410806 0.499937885022666 no 1678 0.492740104226115 542 5718033 SGTC_1625 st003711 30.1 µM 0.0171992150658544 0.49966663646271 no 1679 0.493138844192027 535 24207034 YER133W GLC7 SGTC_1213 1315-0166 115 µM 0.0170169957727016 0.499617192423404 no 1680 0.493211528534601 533 768401 SGTC_2433 5607874 27.82 µM 0.0161101124747925 0.499371115545445 no 1681 0.493573272987193 544 2252428 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.0157688307150301 0.499278511019023 no 1682 0.493709407415317 538 5377381 SGTC_2323 6148992 148.28 µM 0.0156218462787514 0.499238627785491 no 1683 0.493768038499314 538 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_66 0109-0187 42.4 µM 0.0155375538420128 0.499215755605798 no 1684 0.493801662235295 529 759417 SGTC_323 4013-0906 34.3 µM 0.0131171796588674 0.498559004920776 no 1685 0.494767152495861 543 2910086 SGTC_764 1951-2361 146 µM 0.0121453793990395 0.498295315085886 no 1686 0.495154813765597 536 5438930 SGTC_992 3909-8734 162 µM 0.0118707422595771 0.498220794735734 no 1687 0.495264370233002 540 4288319 SGTC_2157 5649910 96.377 µM 0.00739697680268129 0.49700688879614 no 1688 0.49704906011653 541 2858091 SGTC_1340 1486-1359 257 µM 0.00654344232277958 0.496775294618468 no 1689 0.497389562826445 540 4309068 SGTC_2593 nobiletin 86.24 µM 0.0061219695922226 0.496660934513783 no 1690 0.497557702745951 544 72344 An anti-infammatory. SGTC_2162 5663267 200 µM 0.00399161706136006 0.496082900706913 no 1691 0.498407579415728 543 6456493 SGTC_2595 hexamethylquercetagetin 100 µM 0.00350930506115095 0.495952034900495 no 1692 0.498599992709848 546 386331 SGTC_2104 5389443 200 µM 0.00216550575113922 0.495587423920866 no 1693 0.499136088872624 546 2244536 SGTC_1174 0739-0097 51.1 µM 0.00190502708348945 0.495516749065569 no 1694 0.499240004610773 545 728447 SGTC_427 1354-0053 47.3 µM 0.00172854810723179 0.495468865661416 no 1695 0.49931040941972 543 6813657 SGTC_587 k089-0003 57 µM 0.00163679133301716 0.495443969652542 no 1696 0.499347015024632 546 9659696 SGTC_2845 9003024 42.97 µM -7.45633686169765e-05 0.494979637789976 no 1697 0.499970253519717 549 2990173 SGTC_1106 tegaserod maleate 11.7 µM -0.000332800799114665 0.494909572313372 no 1698 0.499867231692733 548 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1511 0906-3109 28.5 µM -0.000616352792843654 0.494832638621714 no 1699 0.49975411082686 548 2882180 SGTC_3269 9137823 49.47 µM -0.000631668339764445 0.494828483193269 no 1700 0.499748000808835 548 17682936 SGTC_574 1315-0397 40 µM -0.00084125751381221 0.49477161732007 no 1701 0.499664386848621 549 6794277 SGTC_3087 9117406 49.47 µM -0.00247432096933118 0.494328537192757 no 1702 0.499012889757275 548 42546093 SGTC_2366 9070441 60.58 µM -0.00334506215801178 0.49409229193121 no 1703 0.498665515763287 551 6837235 SGTC_329 k048-0121 21.3 µM -0.00426197390214243 0.493843522140534 no 1704 0.498299723559892 555 6832902 SGTC_2131 toluylene red 5.2905 µM -0.00492028585515656 0.49366491522549 no 1705 0.498037097860773 550 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2910 7948405 25.97 µM -0.00674015017497141 0.493171173727766 no 1706 0.49731108947833 550 2971328 SGTC_3332 9141069 11.198 µM -0.00748437723416342 0.492969262864391 no 1707 0.497014193354287 551 17332883 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.00826937896593375 0.492756291672422 no 1708 0.496701032696546 563 5024745 SGTC_321 4534-3890 65.3 µM -0.00983437643649074 0.492331713637246 no 1709 0.496076714678266 550 699746 SGTC_773 4358-1457 44.6 µM -0.00991791724880496 0.492309049563313 no 1710 0.496043388341441 555 1186886 SGTC_2415 st077333 57.7 µM -0.0104595061840549 0.49216212064619 no 1711 0.49582733683364 551 2766255 SGTC_386 1509-0011 3.07 µM -0.0110330223825183 0.492006531267575 no 1712 0.495598550187487 555 3107280 SGTC_2393 9031399 185.94 µM -0.0116890486360948 0.49182855920435 no 1713 0.49533685047232 560 1526623 YDL150W RPC53 SGTC_1994 st072947 40.9 µM -0.0127817534496044 0.491532125108001 no 1714 0.494900956972845 558 5286565 YDL195W SEC31 SGTC_799 1310-0557 151 µM -0.0129552737332331 0.491485052136166 no 1715 0.494831738126796 559 5354492 SGTC_907 3448-6986 75.5 µM -0.015825053529853 0.490706549525712 no 1716 0.493686980555776 558 590582 SGTC_969 1313-0238 134 µM -0.0169525661938564 0.490400691833871 no 1717 0.493237228510438 555 5212874 SGTC_3015 9080845 49.47 µM -0.0170282796870594 0.490380153414 no 1718 0.493207027556247 552 5296973 SGTC_1073 triclabendazole 3.09 µM -0.0172357769205437 0.490323866810222 no 1719 0.493124260284145 556 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3133 9127736 49.47 µM -0.0185102662791279 0.489978147541572 no 1720 0.492615893831505 561 27243420 SGTC_744 1594-0068 283 µM -0.019349239882258 0.489750570809295 no 1721 0.492281251761336 559 668392 SGTC_1987 st072290 61.9 µM -0.0199323370863256 0.489592404079626 no 1722 0.492048674500239 558 54697379 SGTC_1687 st020778 55.3625 µM -0.0200378938715477 0.489563771683855 no 1723 0.492006571844492 553 4259299 SGTC_552 k242-0005 476 µM -0.0208188739252417 0.489351931653631 no 1724 0.491695070893232 558 4088318 SGTC_448 monastrol 171 µM -0.0216872740416915 0.489116382551532 no 1725 0.49134870761515 551 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2207 7258803 200 µM -0.0221714023427992 0.488985066862031 no 1726 0.491155614802935 558 3666799 SGTC_982 1491-0518 27.5 µM -0.0227877040565884 0.488817901986386 no 1727 0.490909808110343 561 3091256 SGTC_2680 butyl paraben 22.24 µM -0.0234594057623441 0.488635712727078 no 1728 0.490641909537231 556 7184 An antifungal and steroid mimetic. SGTC_296 1222-0039 74.9 µM -0.0238756617232583 0.488522810576052 no 1729 0.490475893939661 569 5984176 SGTC_1445 4239-0156 97.7 µM -0.026337386175931 0.48785512996835 no 1730 0.489494117694595 583 4008346 SGTC_512 prima-1 270 µM -0.0271586800167623 0.487632382228622 no 1731 0.489166586054463 557 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3066 9117245 49.47 µM -0.0272528954081703 0.487606829785726 no 1732 0.489129013458723 572 17176980 SGTC_1878 temozolomide 1 mM -0.0284031540583988 0.487294868771986 no 1733 0.488670304321357 556 5394 DNA alkylating agent. SGTC_3076 9116187 49.47 µM -0.0284467995722742 0.487283031848134 no 1734 0.488652899313388 573 27241210 SGTC_2308 7584454 197.62 µM -0.0284822253421092 0.48727342417616 no 1735 0.488638772200239 565 893577 SGTC_1657 st012939 43.4 µM -0.0289268473144268 0.487152840776935 no 1736 0.48846146675864 569 24207257 SGTC_1832 st054113 55 µM -0.0294502409459229 0.487010895669429 no 1737 0.488252751840605 557 1251267 SGTC_2459 5811157 9.22 µM -0.0302647111817253 0.486790013446447 no 1738 0.487927970035092 559 2870684 YBR192W RIM2 SGTC_1287 0971-0001 34.6 µM -0.0311845594186538 0.48654055785821 no 1739 0.487561176862585 568 4665869 SGTC_2636 apigenin dimethyl ether 100 µM -0.0315632085549785 0.486437872722917 no 1740 0.487410192040593 574 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2733 amorolfine 100 µM -0.031956246154851 0.486331286558894 no 1741 0.487253471785475 562 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3101 9120531 49.47 µM -0.0321296833618597 0.486284253184131 no 1742 0.487184315862783 563 24824904 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.0345329148315756 0.485632555475333 no 1743 0.486226097876603 564 165521 SGTC_1311 1190-0148 100 µM -0.0351191556507796 0.485473587031243 no 1744 0.485992363416396 566 1961333 SGTC_632 0781-2353 4.65 µM -0.0356836215559169 0.485320525379746 no 1745 0.485767315169964 579 6811515 YHR007C ERG11 SGTC_1988 st071872 53.4 µM -0.0361105177579382 0.485204768826475 no 1746 0.485597117920315 568 16414116 SGTC_520 3584-0023 682 µM -0.037005817671177 0.484962004664949 no 1747 0.485240183544242 567 1340790 SGTC_2646 retinol 96.75 µM -0.0374196758944913 0.48484978722645 no 1748 0.485075192280609 570 445354 A vitamin A analog and teratogen. SGTC_3161 9100388 49.47 µM -0.0393673664679424 0.484321688214988 no 1749 0.484298748758423 565 25236368 SGTC_1570 verbenone 133 µM -0.039766444569318 0.484213485094344 no 1750 0.484139664207023 560 29025 A natural terpanoid with antifungal properties. SGTC_1235 benzylparaben 21.5 µM -0.0439941001750007 0.483067302392269 no 1751 0.482454553347125 576 7180 SGTC_3009 9080819 71.4286 µM -0.0464610837291527 0.482398529105095 no 1752 0.481471375628039 572 17027216 SGTC_3266 9136860 49.47 µM -0.0472760288197241 0.482177616854772 no 1753 0.481146616473114 582 4871271 YPR165W RHO1 SGTC_1914 st062367 72.6 µM -0.0475564870975001 0.482101592541784 no 1754 0.481034855515395 586 978205 SGTC_115 0527-0192 112.043 µM -0.0494181158684196 0.48159697422398 no 1755 0.480293045712233 580 4233931 SGTC_652 0437-0092 114 µM -0.0505235066720385 0.481297357790675 no 1756 0.4798526088536 572 3091274 SGTC_1693 xanthone 101.9 µM -0.0509508130488975 0.481181539120207 no 1757 0.479682357551075 565 7020 An insecticide. SGTC_959 1222-0044 107 µM -0.051387304257194 0.481063232599759 no 1758 0.479508450571467 578 6083612 SGTC_2336 9001819 198.65 µM -0.0548358637994947 0.480128594951583 no 1759 0.478134614097172 564 2989602 SGTC_2924 9010168 62.78 µM -0.0564707879225279 0.479685531384882 no 1760 0.477483383119462 589 2993929 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0565602792431657 0.479661280004182 no 1761 0.477447738218427 586 165506 SGTC_2710 st078562 53.7235 µM -0.0586895397091392 0.479084291078642 no 1762 0.476599695540082 580 17250908 SGTC_90 0870-0863 4.608 µM -0.059411891222087 0.47888855750881 no 1763 0.476312020982706 579 1738164 SGTC_1377 2944-0135 198 µM -0.0608093589335661 0.478509904084362 no 1764 0.475755518382924 579 1894137 SGTC_169 k015-0017 16.025 µM -0.0612125864632956 0.478400650420909 no 1765 0.47559495299144 584 1840002 SGTC_3034 9090421 49.47 µM -0.0615498154226698 0.478309280179282 no 1766 0.475460671303747 576 17173761 SGTC_1009 4106-0057 9.87 µM -0.0616223883973358 0.478289617099254 no 1767 0.475431773729793 578 2928005 SGTC_1068 loratadine 26.9 µM -0.0649988296591959 0.477374855964199 no 1768 0.474087466041291 593 3957 A H1 histamine antagonist. SGTC_2994 9053520 71.4286 µM -0.0668684849142702 0.476868371254387 no 1769 0.473343201129663 597 4647384 SGTC_1084 voriconazole 435 nM -0.0694044332522138 0.476181449360106 no 1770 0.472333850103027 581 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2742 clothiapine 36.27 µM -0.0695699090568539 0.476136628742408 no 1771 0.472267993992351 577 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_341 1486-1430 230 µM -0.0705134394396495 0.47588107079392 no 1772 0.47189250202529 586 2054753 YPL210C SRP72 SGTC_2499 avocadenofuran 51.48 µM -0.0708489749159307 0.475790192420199 no 1773 0.471758976689911 616 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_20 0481-0013 4.944 µM -0.0708577839244993 0.475787806554191 no 1774 0.471755471214095 579 182045 SGTC_1712 st032288 53.4 µM -0.073065299373079 0.47518994210876 no 1775 0.470877077456875 580 2883011 SGTC_2331 7980721 200 µM -0.0750549874499588 0.474651119975348 no 1776 0.470085480784166 589 2981221 SGTC_2064 5220758 200 µM -0.0751905890816007 0.474614399734724 no 1777 0.470031535991931 577 788518 SGTC_728 3030-5151 22.5 µM -0.0757589306532988 0.474460498041944 no 1778 0.469805445385955 586 3125388 SGTC_1031 k035-0009 16 µM -0.0759185873753954 0.474417265148425 no 1779 0.469741934474153 590 5180959 SGTC_2715 st079500 56.4 µM -0.07753789323674 0.473978796005585 no 1780 0.46909782377624 584 28246688 SGTC_3232 9132874 49.47 µM -0.0799180123852061 0.473334374257726 no 1781 0.468151231919556 595 3784940 SGTC_2227 7312221 64.1025 µM -0.0803866683934215 0.473207492929211 no 1782 0.467964864835265 575 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_500 h-89 112 µM -0.0815084166422675 0.47290380809326 no 1783 0.467518815819788 597 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_884 0851-0618 334 µM -0.0822737808746996 0.472696614202185 no 1784 0.467214501775726 594 9642473 SGTC_687 k029-0044 34.9 µM -0.0840237551407529 0.472222901622148 no 1785 0.466518772340013 576 5829338 SGTC_107 0358-0022 2.6945 µM -0.0841522465431632 0.472188120940113 no 1786 0.466467692593686 610 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2041 5107442 45.335 µM -0.0874362129056405 0.471299273552523 no 1787 0.465162392926409 584 793005 SGTC_526 4469-0568 170 µM -0.0891809420297529 0.470827098223566 no 1788 0.464469055538904 592 2901964 SGTC_1960 st011366 51.8 µM -0.0895432968039238 0.470729039420307 no 1789 0.464325072941887 573 3972846 SGTC_2256 7954252 200 µM -0.0904565484230792 0.470481907301438 no 1790 0.46396221083984 610 2972920 SGTC_1353 1498-1206 8.11 µM -0.0934585982044476 0.469669612764562 no 1791 0.462769619766519 593 6756808 SGTC_2404 5161160 200 µM -0.0946646759323183 0.46934330763923 no 1792 0.462290588228261 598 2831543 SGTC_2340 7987427 183.45 µM -0.0950313453249961 0.469244109064221 no 1793 0.462144964805512 585 2239331 SGTC_1497 4476-2978 41.3 µM -0.0951790612101929 0.469204146613229 no 1794 0.462086300603155 584 1528379 SGTC_354 2783-3500 4.88 µM -0.0960283246279535 0.468974396395765 no 1795 0.461749038355585 592 6740761 SGTC_450 aminopyrene 156 nM -0.0962519205356544 0.468913908977021 no 1796 0.46166024778632 588 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_483 fpl-64176 144 µM -0.0981191782284915 0.468408804455306 no 1797 0.460918829491476 590 3423 SGTC_709 3807-1509 243 µM -0.0985271350656599 0.468298456398852 no 1798 0.460756863057527 604 1886677 YPL242C IQG1 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0989107017546973 0.468194707843707 no 1799 0.460604585902355 620 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_484 loperamide 105 µM -0.100465274661137 0.467774243331481 no 1800 0.459987475064178 582 3955 An opioid-receptor agonist. SGTC_1780 st038448 24.544 µM -0.101992172606664 0.467361299044219 no 1801 0.459381444019818 638 728868 YDL195W SEC31 SGTC_3132 9126706 49.47 µM -0.102320623188881 0.467272475291419 no 1802 0.459251093140069 593 850858 SGTC_2070 5230947 200 µM -0.10264312231686 0.467185262591608 no 1803 0.459123108452592 626 2835538 SGTC_2375 9072683 200 µM -0.102906566574414 0.467114021133844 no 1804 0.459018563000098 593 16798029 SGTC_824 1304-0008 100 µM -0.103408629133989 0.466978254653204 no 1805 0.45881933190278 598 768245 SGTC_370 0180-0345 38.7 µM -0.105971763021171 0.466285198712737 no 1806 0.457802377926179 595 3989527 SGTC_1978 st071761 42 µM -0.107295784294191 0.465927231256491 no 1807 0.45727716444154 589 5147680 SGTC_61 0978-8327 98.565 µM -0.10837271719086 0.465636087874399 no 1808 0.45685002108963 628 6150059 YHR072W ERG7 SGTC_986 1493-0483 84 µM -0.108672941224099 0.465554927091421 no 1809 0.456730952247126 594 40079 SGTC_1923 st058458 19.1 µM -0.111657783088993 0.464748101133683 no 1810 0.455547377074198 648 3534982 SGTC_2970 9090938 41.86 µM -0.111668433293956 0.46474522255799 no 1811 0.455543154663251 604 17217104 SGTC_739 1486-1183 203 µM -0.113272673922838 0.464311643788767 no 1812 0.454907190418137 617 4346692 SGTC_2117 5521686 200 µM -0.113449315250135 0.464263905445785 no 1813 0.454837172065714 609 803312 SGTC_2555 cholic acid 100 µM -0.11456695753493 0.463961868090788 no 1814 0.454394185638857 590 6708657 Influences liver metabolism. SGTC_2693 st077581 40.7 µM -0.117319959972727 0.463217971606236 no 1815 0.453303254241781 632 25238761 SGTC_3257 9139206 32.98 µM -0.118607896772132 0.462869998599548 no 1816 0.45279300440025 594 4910041 SGTC_2972 9093619 59.92 µM -0.119436425419361 0.462646162860498 no 1817 0.452464802255122 593 25236256 SGTC_3304 9125678 46.087 µM -0.119779509235105 0.462553478613592 no 1818 0.452328907162931 606 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_629 3448-6466 76.7 µM -0.120845128798142 0.462265613996567 no 1819 0.451906852199169 613 573744 SGTC_1296 1068-0102 11.9 µM -0.121773231032221 0.462014914168858 no 1820 0.451539307344172 625 767053 SGTC_2114 5491910 81.25 µM -0.123690617771297 0.461497035805295 no 1821 0.450780120272848 608 2849228 SGTC_2025 5147754 141 µM -0.124413128639437 0.461301905444073 no 1822 0.450494089479511 599 315777 YLR208W SEC13 SGTC_902 1120-0002 2.07 µM -0.124441061803414 0.46129436164966 no 1823 0.450483031690454 607 3280475 SGTC_1256 0570-0116 285 µM -0.124565008769804 0.461260887971588 no 1824 0.450433965768154 623 410638 SGTC_1971 st069429 63.5 µM -0.124750271404567 0.461210855618691 no 1825 0.450360628701342 597 1246522 YGL099W LSG1 SGTC_3336 9143619 71.43 µM -0.12494580486621 0.461158050174189 no 1826 0.450283227718943 611 45595730 SGTC_160 3453-0671 289.699 µM -0.125556167736501 0.460993220992599 no 1827 0.450041630683284 628 5322268 SGTC_2165 5727197 32.143 µM -0.125996403382988 0.460874339017779 no 1828 0.449867385785955 622 1361712 SGTC_694 1315-0438 43.2 µM -0.126409371376847 0.460762823624067 no 1829 0.449703942187269 611 6793154 SGTC_1717 st033143 58.0435 µM -0.126449081655825 0.460752100661608 no 1830 0.449688226186312 617 674616 SGTC_1470 k295-0292 231 µM -0.127178499043604 0.460555141245641 no 1831 0.449399561230586 596 5045612 SGTC_1612 st002233 45.4 µM -0.127795658381599 0.460388501632281 no 1832 0.449155343000669 589 1035021 SGTC_947 3447-0010 211 µM -0.128414121561055 0.460221516946575 no 1833 0.448910628145139 618 748350 SGTC_1055 3448-0672 86 µM -0.129710633156147 0.459871482400399 no 1834 0.448397684801606 623 748378 SGTC_2765 myclobutanil 7.74 µM -0.129898459739111 0.459820775212399 no 1835 0.448323381457319 607 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_509 pifithrin 175 µM -0.130266276929546 0.459721478193643 no 1836 0.448177879898572 598 4817 A p53 inhibitor. SGTC_2093 5331342 194.4 µM -0.131677871624613 0.45934042328264 no 1837 0.447619544487577 603 33839 SGTC_3348 9149464 3.537 µM -0.133427376855453 0.458868202508099 no 1838 0.446927697687375 602 1951442 SGTC_1210 3013-0140 750 nM -0.135057646195897 0.45842821772054 no 1839 0.446283148362284 610 905973 SGTC_2571 chrysanthemic acid 100 µM -0.136238946778 0.458109434532155 no 1840 0.445816193556077 662 2743 An insecticide. SGTC_3008 9078912 71.4286 µM -0.136251629891647 0.458106012040708 no 1841 0.445811180470786 634 16648731 SGTC_3173 9105693 49.47 µM -0.13785212861354 0.457674148374338 no 1842 0.445178642460503 636 17096658 SGTC_1946 st076057 65.1 µM -0.13792110617891 0.457655537230175 no 1843 0.445151384750441 613 953009 SGTC_1400 3771-8998 51.5 µM -0.138058954593669 0.457618344013602 no 1844 0.445096912278098 603 670767 SGTC_442 cape 100 µM -0.138539592470819 0.457488664842457 no 1845 0.444906990509104 605 5281787 SGTC_951 1171-0579 82.7 µM -0.138914352326828 0.457387555377666 no 1846 0.444758914708117 622 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1396 3511-0007 98.6 µM -0.139238942826863 0.457299983734172 no 1847 0.444630668143958 617 X1396 SGTC_1984 st072354 53.1 µM -0.139579094843612 0.457208215956034 no 1848 0.444496279403185 614 5762938 SGTC_1753 st043925 64 µM -0.139732295924162 0.457166885407686 no 1849 0.444435754135853 617 670181 SGTC_281 1672-3440 14.9 µM -0.141904476565112 0.456580925131383 no 1850 0.443577729158016 611 6833000 SGTC_79 0052-0007 94.094 µM -0.141928833488097 0.456574355221104 no 1851 0.443568109512465 602 2801472 SGTC_1356 1502-0781 85.8 µM -0.145084510312735 0.455723260341828 no 1852 0.442322073932375 606 567702 SGTC_299 1273-0059 1.44 µM -0.148423796021674 0.454822866923244 no 1853 0.441004160772685 619 2848077 SGTC_1916 st067606 49.2 µM -0.148674207379165 0.454755356169282 no 1854 0.440905357269953 612 19590279 SGTC_2983 9022671 12.99 µM -0.148826798555559 0.454714218319 no 1855 0.440845151968938 658 6405161 SGTC_906 1165-0455 526 µM -0.150288231730693 0.454320247599975 no 1856 0.440268608628954 642 3252859 SGTC_1468 k284-1086 134 µM -0.151464151825489 0.454003277628124 no 1857 0.439804793623578 620 15996457 SGTC_2750 bromebric acid 70.15 µM -0.151577655287114 0.453972684248492 no 1858 0.439760029119328 632 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2904 7225135 42.03 µM -0.151622171167741 0.453960685647263 no 1859 0.439742472760803 620 4446116 SGTC_3171 9103192 49.47 µM -0.152067410185679 0.453840680328697 no 1860 0.439566884066581 597 13018434 SGTC_465 cgp-37157 41 µM -0.152731956205308 0.453661573013673 no 1861 0.439304829501072 625 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2534 helenine 20.12 µM -0.153054675537319 0.453574597644542 no 1862 0.439177579166602 594 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1715 st032160 10.2275 µM -0.153522746283533 0.453448452897106 no 1863 0.438993026995252 620 5289825 SGTC_1645 Cervolide 78 µM -0.154320428109254 0.453233489017301 no 1864 0.438678545474549 613 23173 A fragrance. SGTC_1928 4'-methoxychalcone 40.3 µM -0.155318926784982 0.452964427178547 no 1865 0.438284947630919 607 641818 SGTC_3036 9090181 49.47 µM -0.15535201029426 0.452955512653466 no 1866 0.438271907496535 605 25236586 SGTC_1958 st076513 41.9 µM -0.155528618776547 0.452907924972919 no 1867 0.438202296960345 644 732122 YGL099W LSG1 SGTC_2345 9052315 157.45 µM -0.157871834176004 0.452276602896525 no 1868 0.437278896387335 612 6469265 SGTC_2261 9010538 184.68 µM -0.15830419468121 0.452160127070302 no 1869 0.437108551472552 689 6457250 SGTC_2616 abietic acid 100 µM -0.159391405982665 0.451867255826826 no 1870 0.436680254693303 606 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_365 0121-0052 13.6 µM -0.161953106550096 0.451177292865151 no 1871 0.43567139090497 620 3101739 SGTC_2033 5192550 145 µM -0.161975068481039 0.451171378320196 no 1872 0.435662743529796 611 182073 SGTC_226 1,3-diallylurea 8.28947 mM -0.166199902389216 0.450033795832117 no 1873 0.433999818130609 616 74537 YKL182W FAS1 SGTC_2442 5158906 48.48 µM -0.169955933700801 0.44902278789133 no 1874 0.432522396096609 605 1893835 SGTC_3206 9114350 49.47 µM -0.172026504861252 0.448465594974089 no 1875 0.431708345871286 641 17087243 SGTC_257 daunorubicin 18.5 µM -0.177645872862411 0.446953932384032 no 1876 0.429500548073574 629 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_835 0312-0010 67.2 µM -0.17927472609988 0.446515898662711 no 1877 0.428860995497855 631 1626196 SGTC_1897 st060201 15 µM -0.17942962474732 0.446474246469217 no 1878 0.428800185824353 623 611878 SGTC_2107 5363541 170.161 µM -0.180703616873431 0.446131692864665 no 1879 0.428300109836259 630 244052 SGTC_1282 0886-0010 32.4 µM -0.182723919724448 0.445588552231622 no 1880 0.427507323251958 630 2836211 YNL267W PIK1 SGTC_2060 5238662 140 µM -0.183203186108885 0.445459720629879 no 1881 0.427319297262382 651 790130 SGTC_2980 9014342 25.29 µM -0.184823089889851 0.445024316987062 no 1882 0.426683898371888 641 2996599 SGTC_499 genistein 192 µM -0.184930692138429 0.44499539760549 no 1883 0.426641698664842 642 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1165 k072-0275 30.3 µM -0.186376015354083 0.44460697827074 no 1884 0.426074949932277 627 6153523 YGL055W OLE1 SGTC_402 epigallocatechin gallate 10 µM -0.186500051752085 0.444573646929566 no 1885 0.426026319138318 643 65064 An antioxidant. SGTC_2364 9055074 200 µM -0.187910877525274 0.444194554278694 no 1886 0.425473257802275 645 6470630 SGTC_2277 7947813 106.88 µM -0.188858851405166 0.443939859820708 no 1887 0.425101722475789 667 1246798 SGTC_2963 9082507 9 µM -0.190494142270247 0.443500556704473 no 1888 0.424460966469338 650 16459611 SGTC_2000 st075254 36.4 µM -0.192154070117189 0.443054706137414 no 1889 0.423810761068608 627 17234175 SGTC_1575 cyproterone acetate 48 µM -0.192905990889868 0.442852766650738 no 1890 0.423516296554422 665 9880 An androgen receptor antagonist and liver toxin. SGTC_108 0509-0257 621.132 µM -0.193846503659827 0.442600198885626 no 1891 0.423148036458357 626 536624 SGTC_1295 1013-0063 9.78 µM -0.196867628361983 0.441789056447876 no 1892 0.421965563362298 635 6826038 SGTC_665 3914-0008 307 µM -0.197512765802671 0.441615874860362 no 1893 0.421713146270962 661 1069549 SGTC_2921 7974240 10.71 µM -0.20018991438465 0.44089733700828 no 1894 0.420666027339119 657 2979074 YDR527W RBA50 SGTC_527 4476-4215 268 µM -0.200980948382072 0.440685063216689 no 1895 0.420356735550434 617 4418754 SGTC_1440 4100-1550 40 µM -0.201592958074997 0.440520842246822 no 1896 0.42011747542439 659 742806 SGTC_2035 5154463 94.595 µM -0.20205103294106 0.440397933404056 no 1897 0.4199384141552 647 2769623 SGTC_2294 7971431 200 µM -0.203875850152379 0.439908362759707 no 1898 0.419225258749282 664 5741572 SGTC_2121 5257820 149.641 µM -0.204056576448372 0.439859881636745 no 1899 0.419154643644713 626 791256 SGTC_1476 4112-3294 3.34 µM -0.207634041649606 0.438900387508665 no 1900 0.417757361093137 623 704369 SGTC_1886 st057356 49.9 µM -0.210218644351417 0.438207407085865 no 1901 0.416748514294834 627 24207747 SGTC_1866 st057638 64 µM -0.210582650636701 0.438109825348459 no 1902 0.416606475761821 640 688802 SGTC_1085 doxorubicin 7.67 µM -0.210893338841514 0.438026539942121 no 1903 0.416485251035648 643 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_211 3455-0679 143.504 µM -0.211792473031731 0.437785526779458 no 1904 0.416134470486409 643 748649 SGTC_1366 1683-0113 21.9 µM -0.212183043949793 0.437680841323993 no 1905 0.415982117270029 649 708623 SGTC_690 glyoxal 20.3 µM -0.21290371632245 0.437487689611745 no 1906 0.415701031816252 645 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1926 methyl fluorone black 53.6 µM -0.21305652861792 0.437446735387259 no 1907 0.415641435632512 623 72721 Reacts with homocysteine. SGTC_1063 disulfiram 1.84 µM -0.214216242277929 0.437135949983041 no 1908 0.415189215278674 627 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1565 sinapyl alcohol 95.1 µM -0.214509450963794 0.437057380705506 no 1909 0.415074898844409 644 5280507 A phenol propionate derived from cinnamic acid. SGTC_1771 st048882 4.1505 µM -0.218509165489949 0.435985851678049 no 1910 0.413516208912339 646 4580403 SGTC_1373 2887-0003 58.5 µM -0.220021332163287 0.435580862076864 no 1911 0.41292727054671 634 776948 SGTC_2931 9014674 55.67 µM -0.220750794893634 0.435385520953475 no 1912 0.412643239169683 643 2996810 SGTC_963 1269-2853 151 µM -0.221044144290955 0.435306970044791 no 1913 0.41252903041009 626 3668223 SGTC_2804 7954240 19.48 µM -0.223341059372129 0.434692007779836 no 1914 0.411635036722557 649 828705 SGTC_518 1021-0119 62.6 µM -0.223573204133371 0.434629863499044 no 1915 0.411544707947732 663 1097762 SGTC_2563 tomatine 8.54 µM -0.224476124410431 0.434388170502733 no 1916 0.411193421432854 705 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2587 piperic acid 92.2 µM -0.225540369722187 0.434103325638273 no 1917 0.410779461881976 633 5370536 SGTC_359 0081-0058 15.9 µM -0.225578100518616 0.434093227631652 no 1918 0.410764787553208 645 3494159 SGTC_1049 3226-0134 66 µM -0.226070043816554 0.433961571304391 no 1919 0.410573471524131 633 5702385 SGTC_291 SEC14.278 35.5 µM -0.228798903377 0.433231393669223 no 1920 0.409512609581448 645 1068044 SGTC_1675 st018485 24.5 µM -0.231050834871186 0.432629002085344 no 1921 0.408637654882179 648 3323024 SGTC_3300 9124615 50.48 µM -0.231085651316725 0.432619689912863 no 1922 0.40862413102873 656 24824903 SGTC_2905 7799065 20.05 µM -0.231600018157252 0.432482119269148 no 1923 0.40842434670343 694 1296806 SGTC_2271 7849410 118.62 µM -0.232543256005332 0.432229865656942 no 1924 0.408058047210647 653 972430 SGTC_1119 parthenolide 318.541 nM -0.233114855634623 0.432077014073849 no 1925 0.407836109764775 692 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1164 k060-0068 93.7 µM -0.234279237161382 0.431765678025488 no 1926 0.407384101888369 644 5963676 SGTC_1501 4491-0275 38.4 µM -0.234845896517482 0.431614178156766 no 1927 0.407164171738451 662 5104718 SGTC_1822 st052468 42 µM -0.237380434845213 0.430936677141987 no 1928 0.406180833370353 643 2873678 SGTC_2328 6201408 200 µM -0.237921748120699 0.430792006327132 no 1929 0.405970893614362 684 2890418 SGTC_2354 9060492 162 µM -0.239707232387186 0.430314885623927 no 1930 0.405278613878622 679 6471895 SGTC_2860 9025725 38.96 µM -0.240443846621585 0.430118075684181 no 1931 0.404993095145682 688 40546248 SGTC_2469 5655019 90.81 µM -0.24332938606736 0.429347279627798 no 1932 0.403875120788657 670 2788239 SGTC_987 1497-1013 404 µM -0.243469181683361 0.429309943717408 no 1933 0.403820978187364 661 1676435 SGTC_460 trequinsin 123 µM -0.24726858602101 0.428295461141183 no 1934 0.402350184382804 643 5537 A vasodilator. SGTC_507 nimesulide 162 µM -0.247873525059131 0.4281339793336 no 1935 0.402116132355809 670 4495 A COX2 inhibitor. SGTC_56 0957-0365 83.25 µM -0.249213539850492 0.427776320047665 no 1936 0.401597803247858 658 6752360 SGTC_150 3970-0969 77.2 µM -0.250461356959588 0.427443322312032 no 1937 0.401115292584071 659 6615640 SGTC_2278 7948257 134.34 µM -0.251277820625937 0.42722546533273 no 1938 0.400799660868257 640 1247028 SGTC_2229 7354935 190 µM -0.252609369277234 0.426870215877921 no 1939 0.400285044579086 680 318112 SGTC_1906 st060206 94.7 µM -0.252609960256574 0.426870058221208 no 1940 0.400284816216032 665 5133468 SGTC_289 k017-0060 526 µM -0.254647001979218 0.426326702208869 no 1941 0.399497876614547 660 5512909 SGTC_64 000l-0018 272.079 µM -0.254783392280611 0.426290326743548 no 1942 0.399445201549795 662 6811119 SGTC_1358 1509-0022 2.48 µM -0.255219473633001 0.426174027506169 no 1943 0.399276795604132 652 3258434 SGTC_1901 st060216 58.6 µM -0.255269144208735 0.426160781187516 no 1944 0.399257615004002 644 688792 SGTC_1681 tripelennamine 100 µM -0.255845313051439 0.426007132605852 no 1945 0.39903514162428 618 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_396 dithiazanine 1.25 µM -0.256332596155168 0.425877196202402 no 1946 0.398847014870623 652 10578 An antihelmenthic. SGTC_1587 estradiol valerate 56.1 µM -0.25652991890592 0.425824581422183 no 1947 0.39877084060477 686 13791 A steroid. SGTC_695 3505-6186 243 µM -0.25747039281497 0.425573828561625 no 1948 0.398407834083476 675 1819379 SGTC_3337 9144342 33.5465 µM -0.257556255427515 0.425550937031299 no 1949 0.398374696986785 633 17682949 SGTC_308 4092-1169 104 µM -0.260940390961357 0.42464890513693 no 1950 0.397069238033277 656 2268590 YDL196W YDL196W SGTC_1485 3909-9022 254 µM -0.260974047586375 0.4246399360306 no 1951 0.397056260468911 667 714516 SGTC_692 k241-0027 77.8 µM -0.261296101328145 0.424554114358744 no 1952 0.396932086428812 666 3600480 SGTC_1729 st035615 45.989 µM -0.265138438197634 0.423530475993835 no 1953 0.395451408607979 640 17385451 SGTC_769 0302-0231 76 µM -0.26551957581911 0.423428964992523 no 1954 0.395304615782634 674 571869 YER009W NTF2 SGTC_1097 itavastatin 7.23 µM -0.266179452093011 0.423253227630824 no 1955 0.395050503603015 649 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2797 7859098 81.82 µM -0.266504448244414 0.423166680702265 no 1956 0.394925367022375 656 972681 SGTC_315 k915-0449 187 µM -0.267383523894152 0.422932600218747 no 1957 0.394586941905158 663 20970215 YNL149C PGA2 SGTC_1185 1319-0113 81.3 µM -0.267563575042228 0.422884659508252 no 1958 0.394517635912111 687 4672763 SGTC_1811 st050069 61.5 µM -0.269426710755132 0.42238864515021 no 1959 0.39380066682455 670 3877702 SGTC_2332 7982454 138.89 µM -0.269724943252746 0.422309259439715 no 1960 0.393685934789917 691 2981748 SGTC_767 0929-0023 86 µM -0.269866974674156 0.422271453584922 no 1961 0.39363129759661 646 1204563 SGTC_3084 9116877 49.47 µM -0.271167289534802 0.421925369739565 no 1962 0.393131184954765 666 27241325 SGTC_2453 5731132 22.18 µM -0.271564188971354 0.42181974541117 no 1963 0.392978568991999 701 1362040 SGTC_1278 0874-0585 172 µM -0.27201908918311 0.421698692621707 no 1964 0.392803670774339 664 766306 SGTC_2918 7977171 22.06 µM -0.273053396388018 0.421423482290321 no 1965 0.392406085062527 657 2236483 SGTC_2099 5377090 177.372 µM -0.274083627203372 0.421149394766056 no 1966 0.392010177914432 689 2243829 SGTC_2102 5377816 72.7585 µM -0.274585394537626 0.421015916017309 no 1967 0.391817394321464 694 1379702 SGTC_1020 4335-0961 93.3 µM -0.276147732595902 0.420600365406239 no 1968 0.391217300066687 698 669075 SGTC_1288 0973-0013 65.5 µM -0.276190632954041 0.420588956016652 no 1969 0.391200825678694 660 4315430 SGTC_2408 sulbentine 18.36 µM -0.276410635112856 0.420530447289238 no 1970 0.391116344581808 644 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3047 9092122 49.47 µM -0.28360349657184 0.418618507827481 no 1971 0.388357128608312 701 17173831 SGTC_2126 5251174 33.877 µM -0.284627570123911 0.418346453296165 no 1972 0.387964743318326 687 790722 SGTC_330 1488-0319 80.1 µM -0.284909184580009 0.418271646674728 no 1973 0.387856859606148 659 6846614 SGTC_973 1325-0077 65.9 µM -0.285138367819718 0.418210769794734 no 1974 0.387769068162312 693 2835149 SGTC_2266 7929956 200 µM -0.286197293126691 0.417929517843979 no 1975 0.387363508424883 668 2967153 SGTC_2018 5133068 143 µM -0.28691861582503 0.417737957610996 no 1976 0.387087318068803 702 785362 SGTC_1118 chelidonine 707.474 nM -0.290512702696816 0.416783774889987 no 1977 0.385712017136694 669 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2737 bleomycin 30.5 nM -0.291215249128387 0.416597315149111 no 1978 0.385443350319124 680 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1410 3909-8106 77.9 µM -0.291949770801555 0.416402389065611 no 1979 0.385162514347302 681 1039210 SGTC_3176 9106582 49.47 µM -0.292854242702824 0.416162390133164 no 1980 0.38481678258957 657 17018027 SGTC_2003 4023581 200 µM -0.29364849326699 0.415951663877854 no 1981 0.38451325811637 675 16641307 SGTC_602 3130-1533 38.1 µM -0.294421370305444 0.415746631525408 no 1982 0.384217969529458 685 720941 SGTC_2363 9053361 176 µM -0.296162869350887 0.415284722838991 no 1983 0.383552851724611 706 6469797 YMR079W SEC14 SGTC_1746 st038117 42 µM -0.296770401755952 0.415123610727443 no 1984 0.38332090197882 660 2898218 SGTC_2767 sibutramine 71.45 µM -0.298186038977306 0.414748251928814 no 1985 0.382780588338311 709 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1972 st070201 17.4 µM -0.299118362845956 0.414501087032755 no 1986 0.38242486790661 668 2829099 SGTC_1573 oleylamine 1.06 µM -0.299345377217556 0.41444090922208 no 1987 0.38233826746324 702 5356789 An amine of the fatty acid oleic acid. SGTC_2390 9097792 176.6 µM -0.299848118396382 0.414307647878118 no 1988 0.382146504923537 669 4497149 SGTC_1242 0402-0103 60.1 µM -0.30147602683997 0.413876206788756 no 1989 0.38152576398182 667 432868 SGTC_2004 4023728 41.89 µM -0.3049854711399 0.412946460469428 no 1990 0.380188608927684 690 360084 YDR527W RBA50 SGTC_1951 sophoraflavanone G 9.2 µM -0.305092749281124 0.412918047262215 no 1991 0.380147756675639 677 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2186 6124449 200 µM -0.305626879984589 0.412776586593309 no 1992 0.37994437594967 681 3834182 YLR033W RSC58 SGTC_221 trifluoperazine 10.304 µM -0.30638483214242 0.412575867869535 no 1993 0.379655827813898 685 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_42 0133-0086 60.653 µM -0.30644976444356 0.412558673745467 no 1994 0.379631111564629 709 162923 Model of phenazepam hydroxylation. SGTC_1868 st057644 42.7 µM -0.307918081228686 0.412169907173033 no 1995 0.379072333493516 672 688665 SGTC_1338 1486-1223 76 µM -0.309174798694291 0.411837234225092 no 1996 0.378594281562462 687 3444526 SGTC_842 0271-0008 11.1 µM -0.309479698169547 0.411756532063033 no 1997 0.378478326592827 696 1221709 SGTC_941 3237-0776 460 µM -0.310158670304897 0.411576832085264 no 1998 0.378220149030337 685 760008 SGTC_1129 3453-1384 223 µM -0.310218018378592 0.411561125624141 no 1999 0.378197584646517 745 1084452 SGTC_1175 0741-0056 27.6 µM -0.310298165125857 0.411539915021291 no 2000 0.378167113180054 681 765927 SGTC_2054 5233173 129 µM -0.311192807627626 0.411303168055743 no 2001 0.377827025231244 661 6889 SGTC_175 3793-3120 23.7 µM -0.311356162660314 0.411259943314042 no 2002 0.377764937928085 735 5322297 SGTC_1322 1348-1070 12 µM -0.312645611480378 0.410918785114724 no 2003 0.377274960530691 668 6758089 SGTC_3256 9138902 49.47 µM -0.312695160904942 0.41090567683073 no 2004 0.377256136190395 692 17228773 SGTC_3139 9095020 49.47 µM -0.314278020931339 0.410486984162049 no 2005 0.376654944951971 652 25236292 SGTC_360 0957-0399 1.01 µM -0.315530312715523 0.41015580450625 no 2006 0.37617951970051 714 6752301 YPR165W RHO1 SGTC_294 k038-0071 157 µM -0.316854394272666 0.409805709095835 no 2007 0.375677044175401 676 24152826 SGTC_2382 9035899 200 µM -0.319468216325808 0.409114809563481 no 2008 0.374685744663982 715 6462679 SGTC_3147 9097027 49.47 µM -0.320831228598672 0.408754642641886 no 2009 0.374169146198167 676 25236841 SGTC_904 1141-0088 396 µM -0.321252388530387 0.408643369499115 no 2010 0.374009567024516 716 1378119 SGTC_307 1501-1223 22.3 µM -0.324068257060966 0.407899588688199 no 2011 0.3729431791925 712 2830329 SGTC_459 nigericin 15.3 µM -0.325549694737198 0.407508416185271 no 2012 0.372382539047075 740 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_3069 9117009 49.47 µM -0.326272513685197 0.407317589832217 no 2013 0.372109091123451 668 41904981 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.326723626772987 0.407198505778585 no 2014 0.371938464271239 703 688667 SGTC_2379 9035213 200 µM -0.327031753556543 0.407117171932045 no 2015 0.371821934325575 670 646551 SGTC_222 nsc-310342 10.666 µM -0.327092390545403 0.407101166526089 no 2016 0.371799003508005 710 432556 SGTC_2605 digitonin 300 nM -0.330243055591211 0.406269748355077 no 2017 0.370608158175987 698 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3168 9103419 49.47 µM -0.331169490419305 0.406025354857964 no 2018 0.370258232136414 690 16649256 SGTC_529 4076-0302 30.3 µM -0.331433270164177 0.40595577645706 no 2019 0.370158618843655 690 5816522 SGTC_1201 1889-3372 45.9 µM -0.33184311936143 0.405847674536456 no 2020 0.370003861433529 686 5392199 SGTC_2081 5214970 32.255 µM -0.333130524376993 0.405508155016572 no 2021 0.369517879466901 687 2063512 SGTC_1932 st074806 40.9 µM -0.336326812865288 0.404665525062363 no 2022 0.368312216329256 686 17251235 SGTC_1732 st034308 51.822 µM -0.336789700209316 0.404543531712333 no 2023 0.368137719000087 662 830119 SGTC_1800 st050079 29.0735 µM -0.338066051638948 0.40420719907635 no 2024 0.367656706401632 699 3645560 SGTC_1457 k015-0032 57.3 µM -0.338414404276277 0.404115416612696 no 2025 0.367525460387987 704 4302660 SGTC_1709 st033179 39.1045 µM -0.338549010364818 0.404079952589408 no 2026 0.367474750081001 686 573381 SGTC_186 3455-3465 67.277 µM -0.338937842809401 0.403977513190909 no 2027 0.367328277767567 694 755278 SGTC_1464 k208-0027 110 µM -0.339651028432578 0.403789638823932 no 2028 0.367059672520543 692 X1464 SGTC_33 0986-0033 35.816 µM -0.339952408479389 0.403710252998409 no 2029 0.366946184085047 686 2848082 SGTC_1140 3229-1848 2.98 µM -0.341415415806354 0.4033249420205 no 2030 0.36639543571115 717 2849525 SGTC_3164 9100705 49.47 µM -0.341517740272863 0.403297996420602 no 2031 0.366356925995534 709 17174235 SGTC_2976 9009005 19.48 µM -0.345983445326286 0.40212246951644 no 2032 0.364677578021169 704 2993148 SGTC_1646 st011709 75.6 µM -0.348071789107246 0.401573048687516 no 2033 0.363893135105009 678 5757843 SGTC_1395 3486-0190 4.35 µM -0.348682225085603 0.401412486225164 no 2034 0.363663945047656 730 6748079 SGTC_2786 7743617 45.45 µM -0.349782686678035 0.401123074804911 no 2035 0.363250896651274 704 583674 SGTC_3283 9109332 35.8195 µM -0.350830925521057 0.400847447937396 no 2036 0.362857597414057 692 17027281 SGTC_612 0302-0167 22.4 µM -0.351218031773651 0.400745673601922 no 2037 0.362712391681959 699 235821 SGTC_933 2914-0560 114 µM -0.352526629923189 0.400401679201574 no 2038 0.362221675429249 703 463887 SGTC_1364 1653-0028 37.6 µM -0.352938349780358 0.40029346535647 no 2039 0.362067329787305 706 5718652 SGTC_1191 1487-1166 10.6 µM -0.356006729726381 0.399487233380556 no 2040 0.360917762671452 734 3955771 SGTC_2620 irigenin 100 µM -0.358832895290065 0.398745023360856 no 2041 0.359860051201276 688 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_3038 9091290 49.47 µM -0.359571779504661 0.398551037204373 no 2042 0.3595836953041 735 25236843 SGTC_3109 9122853 49.47 µM -0.364768766880655 0.397187334371295 no 2043 0.357642010712277 719 1234709 SGTC_2506 ethyl hematommate 54.16 µM -0.364774538494168 0.397185820580237 no 2044 0.357639856373236 707 3940691 An allergen. SGTC_3292 9120825 59.784 µM -0.365151455433661 0.397086965358649 no 2045 0.357499176443153 726 24824900 SGTC_317 4495-0002 170 µM -0.365639894253397 0.396958870769996 no 2046 0.357316901052089 719 15991618 SGTC_1615 st002656 86.5 µM -0.368439457838912 0.396224891423663 no 2047 0.356272790198892 681 1584458 SGTC_89 0302-0250 142.109 µM -0.369247931469141 0.396012997072015 no 2048 0.355971466026311 699 4203518 YLR208W SEC13 SGTC_331 k048-0133 24.5 µM -0.370214025860862 0.395759831897567 no 2049 0.355611513382307 682 6813582 SGTC_1721 st082152 9.2685 µM -0.373943975116376 0.394782811659196 no 2050 0.354222999250863 696 5296051 SGTC_1005 4092-0690 4.4 µM -0.377168086089664 0.393938822956215 no 2051 0.353024347752259 724 1529343 SGTC_381 3461-2219 42.7 µM -0.377673454536814 0.393806575630172 no 2052 0.352836594990501 751 2883159 SGTC_2212 7123476 200 µM -0.37861173480888 0.393561074272885 no 2053 0.352488103355762 701 1085715 SGTC_524 r073-0010 27.8 µM -0.37883600558983 0.393502400006677 no 2054 0.352404824078539 732 2772106 SGTC_990 3985-0011 41.3 µM -0.379343854987552 0.393369544154468 no 2055 0.35221626868806 740 5399565 YGL099W LSG1 SGTC_2205 7238770 200 µM -0.382257807565274 0.392607480538145 no 2056 0.351135073633429 706 279867 SGTC_502 l-744,832 89.3 µM -0.385597299010715 0.391734635217937 no 2057 0.349897466949379 737 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_196 k015-0023 18.111 µM -0.385753876146713 0.39169372387179 no 2058 0.349839478873168 697 5211998 SGTC_778 3456-2434 196 µM -0.388760965129895 0.39090824780621 no 2059 0.348726489541341 709 5539063 SGTC_2372 9071633 200 µM -0.389575282326303 0.390695617949854 no 2060 0.348425316347118 716 21321366 SGTC_1620 st003704 16.5 µM -0.390672953453568 0.390409052058078 no 2061 0.348019496608294 714 2834414 SGTC_993 3909-8757 62.7 µM -0.392501320369101 0.389931857710192 no 2062 0.347343917975452 686 4288324 YLR208W SEC13 SGTC_1963 st076565 50.3 µM -0.393357304089903 0.389708507318866 no 2063 0.347027799812532 713 4914280 SGTC_3020 9089140 49.47 µM -0.393938231102062 0.389556947751468 no 2064 0.346813321785103 698 17217859 SGTC_2744 captopril 92.04 µM -0.395356724608412 0.389186943888544 no 2065 0.346289820881423 716 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2333 9017922 200 µM -0.395488069636803 0.389152688555962 no 2066 0.346241362287709 700 3163164 SGTC_3306 9127676 59.7925 µM -0.395720443460013 0.389092086601824 no 2067 0.346155636174607 694 41905287 SGTC_2543 pimpinellin 60.67 µM -0.396056438112689 0.38900446561448 no 2068 0.346031696756912 712 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_994 3910-0338 138 µM -0.396284683003086 0.388944946926438 no 2069 0.345947512743255 714 3479481 SGTC_2831 7999036 19.48 µM -0.39849401247364 0.388368962072847 no 2070 0.345133035498334 750 2988270 SGTC_3310 9130229 44.1445 µM -0.399019647811966 0.388231962019098 no 2071 0.344939363567096 735 7761258 SGTC_1203 3992-3522 103 µM -0.399424693984954 0.38812640145768 no 2072 0.344790150784525 771 5322312 SGTC_1604 st002052 72.4 µM -0.399555603332822 0.388092286461629 no 2073 0.344741930953938 694 6254834 YHR062C RPP1 SGTC_631 k072-0230 41.5 µM -0.40045872687546 0.387856955870545 no 2074 0.344409338482908 722 5773147 SGTC_1534 6-azauridine 81.6 µM -0.401148831611948 0.38767716021268 no 2075 0.344155275298526 708 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1508 1080-0625 72.9 µM -0.401994570763606 0.387456849363237 no 2076 0.343844010962297 719 767111 SGTC_545 4218-0007 221 µM -0.402578695103838 0.387304709025333 no 2077 0.343629092640166 742 2840508 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.403100543382747 0.387168803674356 no 2078 0.343437130441619 746 1273210 SGTC_3135 9127742 49.47 µM -0.4034941491076 0.387066305779313 no 2079 0.343292369052224 707 3643468 SGTC_2012 4023501 200 µM -0.403658784533582 0.387023435809737 no 2080 0.343231825802971 773 3477460 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.403892766786859 0.386962510758949 no 2081 0.343145787782405 720 688788 SGTC_2834 9001755 58.44 µM -0.404234972615609 0.386873411121477 no 2082 0.343019969325244 733 2989575 SGTC_132 0417-1715 25.805 µM -0.40480687802971 0.386724518243889 no 2083 0.342809736315959 744 6769098 SGTC_3073 9114972 49.47 µM -0.406628360420713 0.38625041509845 no 2084 0.342140482150045 720 41905075 SGTC_2122 5258151 111.688 µM -0.407228259175956 0.386094308045061 no 2085 0.341920174048246 734 2173356 SGTC_1523 st012844 44.7 µM -0.408058709740338 0.38587823669863 no 2086 0.341615286431268 736 4274103 SGTC_1302 1159-0335 255 µM -0.409187921285966 0.385584488828238 no 2087 0.34120087891169 723 649284 SGTC_3130 9127414 49.47 µM -0.413930737990064 0.384351432769823 no 2088 0.339462415983935 731 1494646 SGTC_413 propylparaben 100 µM -0.414049545912263 0.384320559582784 no 2089 0.33941891099423 736 7175 A pharmaceutical preservative. SGTC_205 1486-1330 71.903 µM -0.41644963659974 0.383697034262536 no 2090 0.338540506700635 722 4118834 SGTC_2463 5473429 200 µM -0.416615774107031 0.38365388412222 no 2091 0.338479734800023 725 5399405 SGTC_2813 7971799 71.43 µM -0.416836811314223 0.383596477368909 no 2092 0.338398887506572 730 2234054 SGTC_188 3229-0966 278.469 µM -0.419354763165681 0.382942707268386 no 2093 0.337478439700059 735 5722370 SGTC_2179 6298986 200 µM -0.420574997596514 0.382626000991553 no 2094 0.337032727059357 725 738374 SGTC_2474 5321570 43.32 µM -0.420893894948044 0.38254324556579 no 2095 0.336916281717403 732 2841384 SGTC_2839 9003951 25.97 µM -0.420998685605699 0.382516053047107 no 2096 0.336878020828378 742 2990634 SGTC_2265 7929201 200 µM -0.424365744647155 0.381642631355408 no 2097 0.335649549435269 758 1265108 SGTC_3137 9097352 49.47 µM -0.425128525612433 0.381444847999683 no 2098 0.335371492108957 788 44120435 SGTC_580 1123-0028 41 µM -0.425548524316154 0.381335958712316 no 2099 0.33521842802926 739 1677248 YPR107C YTH1 SGTC_1371 2421-0008 32.7 µM -0.425677751151254 0.381302457121993 no 2100 0.335171338179841 747 2827552 SGTC_619 1652-1634 108 µM -0.42605738398962 0.381204043825005 no 2101 0.335033016160526 744 5400454 SGTC_3031 9088762 49.47 µM -0.426219374537392 0.381162052894034 no 2102 0.334974000520545 735 205253 SGTC_1739 st037196 92.5 µM -0.431543576972233 0.379782703115303 no 2103 0.33303658715695 742 612214 SGTC_1552 6-methylflavone 10.6 µM -0.432371933151337 0.37956823646816 no 2104 0.332735556857487 749 689013 SGTC_3308 9128332 17.569 µM -0.432751906578929 0.379469871338054 no 2105 0.332597507970282 731 17332805 YDL196W YDL196W SGTC_1757 st041620 31.8375 µM -0.433121709157876 0.379374146663705 no 2106 0.332463176068678 736 5289815 SGTC_733 4069-0007 56.1 µM -0.434862977755525 0.378923512746719 no 2107 0.331830944399057 728 5717425 YNL287W SEC21 SGTC_976 1348-1067 47.6 µM -0.436428579002478 0.378518481335378 no 2108 0.331262903753926 723 5310671 YGL099W LSG1 SGTC_2477 5967686 25.23 µM -0.43649536167066 0.378501207180663 no 2109 0.33123868189397 730 776118 SGTC_1907 st060210 83.7 µM -0.436734959482677 0.378439234271554 no 2110 0.331151786345938 747 688793 SGTC_2712 st079126 47.7 µM -0.438846978660849 0.377893087683891 no 2111 0.330386208750529 732 3152970 SGTC_1301 naphtanilide LB 4.81 µM -0.441305955464412 0.377257528827426 no 2112 0.329495757618601 747 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2402 5553605 200 µM -0.443625524338053 0.376658306550286 no 2113 0.328656674359153 736 6758546 SGTC_309 k408-0051 1.48 µM -0.443808375716092 0.376611082531948 no 2114 0.328590566159999 740 3640463 SGTC_1017 4239-0030 168 µM -0.44419363091035 0.376511590839033 no 2115 0.3284512983217 709 1149593 SGTC_2184 6075246 200 µM -0.446089559482976 0.376022089184746 no 2116 0.327766277087747 734 2267320 SGTC_180 1486-1293 102.781 µM -0.446251215227147 0.375980361197578 no 2117 0.327707895737322 745 4140536 SGTC_2119 5528445 120.635 µM -0.447184695853545 0.375739431433211 no 2118 0.327370855210459 735 791935 SGTC_1041 0206-0046 107 µM -0.447833059067914 0.375572118489524 no 2119 0.327136841335007 754 50494 SGTC_1495 4469-0029 237 µM -0.449856686490847 0.375050063251353 no 2120 0.326406890337989 746 793680 SGTC_2137 5261020 140 µM -0.453510988905635 0.3741079068901 no 2121 0.325090416145709 732 763655 SGTC_506 n9-isopropylolomoucine 153 µM -0.455172372537027 0.373679815234791 no 2122 0.324492617346499 757 6610355 SGTC_581 0958-0271 211 µM -0.455431492018898 0.373613061492141 no 2123 0.324399421718091 740 4591145 SGTC_1056 3448-1962 115 µM -0.456022177980735 0.373460904560551 no 2124 0.324187015090987 733 715507 SGTC_116 0155-0182 31.788 µM -0.456528360825669 0.373330530785944 no 2125 0.324005040720575 741 771486 SGTC_2086 5274770 176.623 µM -0.457921498964564 0.372971785400361 no 2126 0.323504420275197 738 689278 SGTC_1921 5740136 50 µM -0.458201516053109 0.372899691806655 no 2127 0.323403835397656 767 1774243 SGTC_1319 1306-0155 43.7 µM -0.462731837145733 0.371733929154412 no 2128 0.321778297408592 723 3122360 SGTC_2481 5478948 45.16 µM -0.463830407046401 0.371451416825297 no 2129 0.321384628095153 730 77792 SGTC_2321 7390090 138.78 µM -0.465391931152073 0.371049968645509 no 2130 0.320825405703723 758 649046 SGTC_2626 ethyl orsellinate 100 µM -0.466065447387698 0.370876859383141 no 2131 0.320584327362521 752 75653 A natural product. SGTC_232 clozapine 119 µM -0.466192459033505 0.370844217377702 no 2132 0.320538873302443 739 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3191 9110352 49.47 µM -0.471722914179621 0.369423794210913 no 2133 0.318562289635358 755 17122424 SGTC_230 MPP+ 141.667 µM -0.473587671824839 0.368945256658668 no 2134 0.317896984213663 762 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3230 9131665 49.47 µM -0.474069178000834 0.368821724614116 no 2135 0.317725288495636 743 15943720 SGTC_2603 homopterocarpin 100 µM -0.474119174291856 0.368808898672261 no 2136 0.317707463037891 738 101795 A weak amylase inhibitor. SGTC_2948 9070189 9.45 µM -0.475123310724392 0.368551330608173 no 2137 0.317349542159345 754 6473636 YDL196W YDL196W SGTC_1390 3413-2614 145 µM -0.47521951928109 0.36852665553404 no 2138 0.317315257917391 773 3421432 SGTC_927 2425-1185 123 µM -0.475751159572852 0.368390312953165 no 2139 0.317125834384821 754 730375 SGTC_404 fumagillin 50 µM -0.479158678104391 0.367516826992235 no 2140 0.315912874186834 744 12015870 A methionine aminopeptidase binder. SGTC_163 TUB2.036 7.546 µM -0.482106277348863 0.366761789405166 no 2141 0.314865225379033 762 15992207 YJR013W GPI14 SGTC_1035 k081-0041 55.2 µM -0.482895689715414 0.366559666086066 no 2142 0.314584901211081 767 731709 SGTC_326 k292-0812 17.5 µM -0.485670664720153 0.365849447822443 no 2143 0.313600342883554 758 3579357 SGTC_1283 0922-0125 16.4 µM -0.486025808432298 0.365758586588777 no 2144 0.313474433843894 743 3360884 SGTC_1673 st016611 27.3 µM -0.489133111938623 0.364963924664131 no 2145 0.312373730250747 784 5226799 SGTC_3209 9113616 49.47 µM -0.489433310386808 0.364887182552661 no 2146 0.312267479042074 778 16649353 SGTC_1043 0916-0009 19.3 µM -0.494537501829489 0.363583188246705 no 2147 0.310463314047606 786 3101130 SGTC_2536 dehydroabietamide 32.04 µM -0.49464721636823 0.363555176183751 no 2148 0.310424583348044 753 3983547 SGTC_421 streptovitacin 30 mM -0.495958556853665 0.3632204242586 no 2149 0.309961825411416 759 91467 include heat shock SGTC_1346 1488-2224 62.4 µM -0.496195410500666 0.363159972666356 no 2150 0.309878274371186 752 3722427 SGTC_2491 paeonol 100 µM -0.4972730094684 0.36288498270121 no 2151 0.30949827117647 776 11092 Increases levels of cortical cytochrome oxidase. SGTC_410 α-linolenic acid 100 µM -0.497487857488431 0.362830164583889 no 2152 0.309422531760449 759 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_562 3772-2733 112 µM -0.49800373480607 0.362698550818206 no 2153 0.309240704885038 760 2876874 YIL048W NEO1 SGTC_1488 4013-0813 75.9 µM -0.499689275464014 0.362268638562956 no 2154 0.308646942557916 742 2910057 SGTC_779 1360-0071 233 µM -0.500205605029827 0.362136978800265 no 2155 0.308465156045111 770 7566 SGTC_603 3794-0023 45.9 µM -0.500240167794077 0.3621281661639 no 2156 0.308452989050529 777 3802260 SGTC_949 1165-0505 146 µM -0.50070781194445 0.36200893584271 no 2157 0.308288386794061 738 6244267 SGTC_3252 9135871 49.47 µM -0.501245562819909 0.361871847697638 no 2158 0.308099155880673 769 17682838 SGTC_1027 k015-0025 8.67 µM -0.502272534822898 0.361610092286477 no 2159 0.307737913079757 749 3598955 SGTC_2300 7976697 71.57 µM -0.502847713242206 0.361463518648679 no 2160 0.307535672413675 739 2236109 SGTC_1360 1598-0022 39.8 µM -0.503319518951163 0.361343302820247 no 2161 0.307369822679142 783 761525 SGTC_717 1532-0246 73.2 µM -0.50351246052749 0.361294145358567 no 2162 0.30730201095747 764 9561992 SGTC_2951 9072950 58.06 µM -0.5078937191062 0.360178510544776 no 2163 0.305763939865211 783 16488155 SGTC_803 4488-1585 147 µM -0.509441582708096 0.359784649597443 no 2164 0.305221367786239 765 747204 SGTC_2466 5983409 37.09 µM -0.51221766287816 0.359078636467724 no 2165 0.304249341372584 756 2879657 SGTC_445 e6 berbamine 66 µM -0.513085231646255 0.35885809478741 no 2166 0.303945850823353 781 6610268 A calcium/calmodulin antagonist. SGTC_1513 0337-0559 19 µM -0.514205683270921 0.358573338241007 no 2167 0.303554097360899 740 775073 SGTC_1642 st009582 77.7 µM -0.514664150860341 0.358456843908297 no 2168 0.303393864294661 765 6739311 SGTC_1114 scopoletin 1.73284 µM -0.515738618753723 0.358183878585049 no 2169 0.303018489104414 766 5280460 A coumarin with genotoxic properties. SGTC_13 0199-0087 65 µM -0.516559863131692 0.357975292785956 no 2170 0.302731720065077 764 4589825 SGTC_1166 k206-0078 225 µM -0.518067648241546 0.357592444630853 no 2171 0.302205535689713 745 5404595 SGTC_462 ag-879 158 µM -0.518413336193114 0.357504689699577 no 2172 0.302084955940489 782 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.518465013160315 0.357491571842955 no 2173 0.302066932303701 748 6708784 An antioxidant flavonoid SGTC_1207 2099-0101 141 µM -0.519592598891267 0.357205383598907 no 2174 0.301673778818915 783 5837381 SGTC_914 3820-6779 408 µM -0.519638929957778 0.35719362620387 no 2175 0.301657629563982 740 2893481 SGTC_1351 1496-0003 46.5 µM -0.51981476815718 0.35714900512865 no 2176 0.301596342565882 771 3891978 SGTC_823 0417-1665 178 µM -0.519925374291077 0.357120938481919 no 2177 0.301557794552364 788 3429856 SGTC_1637 st007924 17.4 µM -0.522653682987475 0.356428866842102 no 2178 0.300607637750417 763 683336 SGTC_622 1348-1566 26.3 µM -0.524153942816359 0.356048507268342 no 2179 0.30008573607213 756 7340407 SGTC_2607 solasodine 47.35 µM -0.52451493216933 0.355957007312398 no 2180 0.299960218391968 753 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_819 1013-0258 27.7 µM -0.524544098468364 0.355949614893976 no 2181 0.299950078171294 779 5753198 SGTC_894 0960-0238 55.9 µM -0.525343644312375 0.355746985071346 no 2182 0.29967216123328 786 6741907 YDL195W SEC31 SGTC_2989 9073649 71.4286 µM -0.526615924176428 0.355424633758655 no 2183 0.299230165694 805 21367202 SGTC_1264 0783-0040 158 µM -0.528178738675064 0.355028812636747 no 2184 0.298687642379123 754 2855798 SGTC_1459 k035-0031 35.7 µM -0.530307603206836 0.354489877146463 no 2185 0.297949337985722 763 3877128 YMR208W ERG12 SGTC_1935 st074532 41.6 µM -0.531528056962202 0.354181042825446 no 2186 0.297526452023315 773 2829742 SGTC_1635 st007035 42.4 µM -0.533742648506895 0.353620888125681 no 2187 0.296759798957998 779 3716403 SGTC_227 fluconazole 33.516 µM -0.535211188625247 0.353249612915368 no 2188 0.296251915156653 785 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3245 9134821 49.47 µM -0.53860297950827 0.352392637049351 no 2189 0.295080415620353 792 17014901 SGTC_3023 9089636 49.47 µM -0.540180887965329 0.351994214849023 no 2190 0.294536145835552 792 17249241 SGTC_1696 st025591 34.7925 µM -0.541312236021978 0.351708649196925 no 2191 0.294146194021385 785 2787147 SGTC_2226 7298446 200 µM -0.542175085430899 0.351490912001041 no 2192 0.293848948482777 786 3283010 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.542503965378188 0.351407933053657 no 2193 0.293735688244383 749 6708561 SGTC_383 2324-0395 7.37 µM -0.544624306879398 0.350873124691643 no 2194 0.293005966864464 771 3146421 SGTC_1871 st057448 67.3 µM -0.545005239926895 0.350777074178269 no 2195 0.29287495688162 805 691747 SGTC_686 1319-0111 510 µM -0.545871757020336 0.350558621412044 no 2196 0.292577046799546 826 4562600 SGTC_2344 7990960 76.95 µM -0.545990571780602 0.350528671539501 no 2197 0.292536209057984 794 140813 SGTC_3138 9097216 49.47 µM -0.54736317896644 0.350182743131427 no 2198 0.29206462334455 792 25237486 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.548166508793502 0.349980343266168 no 2199 0.291788788124386 777 77254 SGTC_2819 7996655 46.38 µM -0.549960980024141 0.349528378184079 no 2200 0.29117306859288 769 6456960 SGTC_1606 st000094 49.2 µM -0.550660503028492 0.34935225031892 no 2201 0.290933212488877 770 1242210 SGTC_1915 st067105 30.6 µM -0.551716152302525 0.34908651739674 no 2202 0.290571420861748 786 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_200 k038-0079 37.545 µM -0.554347959045308 0.34842434919376 no 2203 0.289670367119724 787 3436683 SGTC_1105 epirubicin 18.1 µM -0.556397461344044 0.347909009649221 no 2204 0.288969586991275 766 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3095 9117207 49.47 µM -0.556914182009073 0.347779126493544 no 2205 0.288793032239618 776 17015229 SGTC_2011 4012611 177 µM -0.557922801899381 0.347525650784525 no 2206 0.28844855019115 772 2049887 SGTC_724 3910-0327 137 µM -0.558263548638644 0.347440033306545 no 2207 0.288332216004505 810 2885483 SGTC_1702 st027038 51 µM -0.558562236616323 0.347364990093272 no 2208 0.288230259279306 774 5521182 SGTC_2598 perillyl alcohol 100 µM -0.558776566872985 0.347311144839347 no 2209 0.288157108425739 762 10819 An apoptosis inducer. SGTC_204 PMA1.184 62.41 µM -0.561146984613261 0.346715840864503 no 2210 0.28734867026373 783 2252213 YGL008C PMA1 SGTC_3221 9128209 49.47 µM -0.561202560757317 0.346701888068617 no 2211 0.287329728732148 792 16460723 SGTC_598 3937-0236 20.2 µM -0.561215632101069 0.346698606442735 no 2212 0.28732527382608 799 1379313 SGTC_1131 3454-3128 32.3 µM -0.561508348616095 0.346625121518615 no 2213 0.287225520296701 768 710982 SGTC_2276 7947513 42.08 µM -0.562618631226144 0.346346443451751 no 2214 0.286847301213143 790 2105100 SGTC_2371 9071574 200 µM -0.564531241343269 0.345866578337644 no 2215 0.286196322365223 790 45596039 SGTC_604 1000-0114 314 µM -0.565304487215484 0.345672644696908 no 2216 0.285933338567026 799 1572745 SGTC_2177 5811945 192 µM -0.568351330319929 0.344908876895935 no 2217 0.284898215554791 782 5343475 SGTC_3237 9133362 49.47 µM -0.568859187007587 0.344781631174623 no 2218 0.284725852198297 796 43845137 SGTC_1572 epiandrosterone 68.9 µM -0.569470468529722 0.34462849519129 no 2219 0.284518453137961 785 441302 A steroid. SGTC_474 dl-dihydrosphingosine 5 µM -0.572823946545594 0.343788847789397 no 2220 0.283381951727128 772 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1778 st046819 58.9 µM -0.573357612800786 0.343655298769674 no 2221 0.283201291947619 802 671715 SGTC_59 0330-0160 1.33 µM -0.578208541657225 0.342442259062891 no 2222 0.281561666321922 812 4293482 SGTC_2630 antimycin a 100 µM -0.579172636457329 0.342201367243182 no 2223 0.281236346205152 801 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_264 promethazine 12.5 mM -0.579359722936282 0.342154628650225 no 2224 0.281173237559415 816 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3184 9108758 49.47 µM -0.580105807662386 0.341968263232501 no 2225 0.280921633771646 796 902885 SGTC_1194 1488-0194 225 µM -0.580783867709656 0.341798923172819 no 2226 0.280693064528336 794 1391452 SGTC_669 0108-0021 26.2 µM -0.582244782431747 0.34143417963087 no 2227 0.280200906434749 840 17201 SGTC_666 0272-0154 136 µM -0.58334493058829 0.341159605628828 no 2228 0.279830560825544 790 6870312 SGTC_425 3825-7017 13.1 µM -0.583688525785551 0.341073868668564 no 2229 0.279714944197186 791 3397440 SGTC_38 0929-0051 58.268 µM -0.585438787128911 0.340637255173549 no 2230 0.279126357377219 792 1379719 SGTC_3001 9076041 71.4286 µM -0.585526721220052 0.340615325098239 no 2231 0.279096802345473 780 16004211 SGTC_466 geldanamycin 89.2 µM -0.586645374871666 0.340336388664354 no 2232 0.278720950833988 774 5288382 HSP90 inhibitor. SGTC_416 estradiol valerate 100 µM -0.586648330209924 0.340335651865976 no 2233 0.27871995820934 798 13791 A steroid. SGTC_1401 3807-4679 7.6 µM -0.58737468739701 0.340154581509614 no 2234 0.278476045092411 806 3291456 SGTC_162 k030-0015 37.8 µM -0.590826302299969 0.339294648078171 no 2235 0.277318404854517 812 1809920 YMR134W ERG29 SGTC_1530 rhein 70.4 µM -0.591342740338169 0.339166054808982 no 2236 0.277145398846815 802 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2505 galangin 7.89 µM -0.592071239248292 0.338984690153912 no 2237 0.276901442573595 795 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3322 9139058 2.11 µM -0.593456001360219 0.338640047303244 no 2238 0.276438010091953 776 4908926 YPR165W RHO1 SGTC_1939 st074455 53.6 µM -0.594343293347644 0.3384192869701 no 2239 0.276141263911095 814 1644229 SGTC_684 1140-0066 328 µM -0.59624780591915 0.337945627329695 no 2240 0.275504846687399 810 6813534 SGTC_3077 9117319 49.47 µM -0.596666944069796 0.337841420457439 no 2241 0.275364883233813 821 17154678 SGTC_1247 0448-0043 5.84 µM -0.59668307503959 0.337837410195352 no 2242 0.275359497293313 805 3089013 YGL099W LSG1 SGTC_1281 0884-0031 11.8 µM -0.59906063721547 0.337246534575026 no 2243 0.274566224722901 806 1548255 SGTC_3074 9116018 49.47 µM -0.600392718025236 0.336915658950031 no 2244 0.274122269861932 849 17027303 SGTC_1816 st051957 91.6 µM -0.602780983279598 0.336322753604075 no 2245 0.273327199598764 808 674121 SGTC_1231 0242-0792 125 µM -0.60334435911731 0.336182950439779 no 2246 0.273139814447032 799 3707635 SGTC_1028 k015-0029 4.8 µM -0.603416693638561 0.336165002082784 no 2247 0.273115759782614 808 4588309 SGTC_2866 9034245 58.44 µM -0.60376236679083 0.336079235398211 no 2248 0.273000821537501 785 6462273 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.603986396018386 0.336023654949581 no 2249 0.272926343382962 773 3256 An antibiotic and ribosome inhibitor. SGTC_1228 0124-0032 52.5 µM -0.604431547132351 0.335913225988624 no 2250 0.272778383521988 784 X1228 SGTC_908 3448-7491 47.7 µM -0.604697344413031 0.33584729621644 no 2251 0.272690056481421 765 1203031 SGTC_1621 st003705 32.4 µM -0.604729680279234 0.335839275800693 no 2252 0.272679311924712 793 24207032 SGTC_790 1575-0012 79.1 µM -0.609679200655729 0.334612506631135 no 2253 0.271037167630321 816 378741 YLR208W SEC13 SGTC_233 rapamycin 362 pM -0.610027442688074 0.334526258948959 no 2254 0.270921814437931 800 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1148 3909-7663 27.7 µM -0.614573977336535 0.333401039897731 no 2255 0.269418052126035 826 4084526 SGTC_553 k007-0256 45.7 µM -0.6161868324654 0.33300223467057 no 2256 0.268885608972765 803 6287000 SGTC_6 0844-0013 19.835 µM -0.616726233191927 0.332868900987492 no 2257 0.268707657499953 827 1584900 SGTC_14 0354-0009 295 µM -0.618465790539579 0.33243904636258 no 2258 0.268134170691885 818 1713507 SGTC_1813 st051246 8.6015 µM -0.619323328654351 0.332227224785278 no 2259 0.267851689537927 795 5291959 SGTC_373 0844-0104 25.9 µM -0.620821267648869 0.331857345560397 no 2260 0.26735861417891 802 5375804 SGTC_1111 tnp00062 510.699 nM -0.624221668801362 0.331018308551159 no 2261 0.266241009077893 793 676306 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.624535012556544 0.330941034688506 no 2262 0.266138141947899 801 2724 A muscle relaxant with antifungal properties. SGTC_2123 5259487 200 µM -0.625664638787719 0.330662516790583 no 2263 0.265767465851222 798 2173474 SGTC_2811 7967822 32.47 µM -0.62664096316573 0.330421872133716 no 2264 0.265447305277353 792 2232244 SGTC_1546 5-methoxyflavanone 78.7 µM -0.62728831975806 0.330262350177694 no 2265 0.265235129214451 799 147795 SGTC_2923 7992654 58.14 µM -0.627745584893237 0.330149689246881 no 2266 0.265085308987859 788 2985126 SGTC_2771 fluoxetine 41.05 µM -0.629441150475323 0.329732070477386 no 2267 0.264530142401509 819 3386 A selective serotonin reuptake inhibitor. SGTC_2687 chenodiol 100 µM -0.631628695763503 0.329193590339807 no 2268 0.26381476551113 786 5702181 A cholesterol synthesis inhibitor. SGTC_628 1636-0253 16 µM -0.632066955641039 0.329085752041681 no 2269 0.263671563301226 812 4456143 SGTC_148 3253-0744 288.01 µM -0.632685074071544 0.328933681893345 no 2270 0.263469659405718 795 6893655 SGTC_997 3996-0078 137 µM -0.636151781901613 0.328081324038769 no 2271 0.262338748761324 800 735687 SGTC_2952 9073731 13.78 µM -0.637936006682993 0.327642985865303 no 2272 0.261757668883883 821 16457353 SGTC_3165 9101544 49.47 µM -0.639031215208796 0.327374038837461 no 2273 0.261401312668671 808 5002184 SGTC_1893 st059353 36.1 µM -0.641225319568382 0.326835508895583 no 2274 0.260688150774882 844 3112488 SGTC_2704 st078022 71.1 µM -0.644011180923694 0.326152255217203 no 2275 0.259784091834773 825 54697681 SGTC_166 k072-0058 166.424 µM -0.644577544692797 0.326013421451561 no 2276 0.259600495333941 818 5846229 SGTC_3117 9124945 49.47 µM -0.645473306243588 0.325793891055665 no 2277 0.259310255731046 799 17592065 SGTC_2247 cerulenin 830 nM -0.645612565264444 0.325759767319335 no 2278 0.259265148873642 795 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_621 3584-0052 32.1 µM -0.646865792852018 0.325452744786882 no 2279 0.258859403232771 827 2273927 SGTC_608 k048-0125 159 µM -0.64796743285273 0.325182956786137 no 2280 0.258503007201352 818 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_138 0850-0259 40.9225 µM -0.649254947837477 0.324867764722384 no 2281 0.258086800314929 809 6813004 SGTC_2385 9074692 200 µM -0.650561679864151 0.32454799634517 no 2282 0.257664736855395 803 17046906 SGTC_1759 st043059 70 µM -0.651685416660968 0.324273111841649 no 2283 0.257302066128041 835 669426 SGTC_508 roscovitine 141 µM -0.654397470927677 0.323610093374583 no 2284 0.256427881685474 844 160355 A CDKinase inhibitor. SGTC_2019 4016004 108 µM -0.654654785301215 0.323547216516678 no 2285 0.256345021239432 824 45595336 SGTC_2955 9076254 12.21 µM -0.657017379581445 0.322970133075382 no 2286 0.255584870757452 803 16459619 SGTC_2567 aureobasidin a 60 nM -0.657749881976711 0.322791299662447 no 2287 0.25534943185412 834 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_919 tnp00227 403.569 nM -0.658521634800046 0.322602927959863 no 2288 0.255101499873656 840 1269246 A methoxyflavone. YNL221C POP1 SGTC_1139 k015-0024 46.9 µM -0.659611121995313 0.322337080217012 no 2289 0.254751707557932 821 2766652 SGTC_2828 7998861 71.43 µM -0.660517268209261 0.322116039026615 no 2290 0.254460970361602 777 2988188 SGTC_618 k072-0232 33.2 µM -0.661173434080487 0.32195601616763 no 2291 0.254250547995688 820 5872756 YGL099W LSG1 SGTC_848 0368-0089 85.6 µM -0.663539314926341 0.321379309758751 no 2292 0.253492604351585 828 762535 SGTC_3340 9146634 11.102 µM -0.664309138192457 0.321191750597552 no 2293 0.25324623675204 804 4907387 SGTC_1860 st056228 74.6 µM -0.664549368527093 0.321133230392619 no 2294 0.253169381290127 847 688679 SGTC_3338 9144300 39.5675 µM -0.664715384004331 0.321092791551692 no 2295 0.253116276114723 806 4901274 SGTC_2794 7785382 27.27 µM -0.667148787615266 0.320500295178752 no 2296 0.252338549725682 822 2205081 SGTC_234 nsc-17383 10.7 µM -0.667629990962274 0.320383183653091 no 2297 0.252184904363688 808 408974 SGTC_955 1216-0110 33 µM -0.667892302934732 0.320319351737785 no 2298 0.252101170496589 829 3619719 SGTC_2735 sertaconazole 140 nM -0.668574742249726 0.320153309471264 no 2299 0.251883394489739 845 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1688 st021091 57.6 µM -0.668797104618661 0.320099214925705 no 2300 0.251812456977714 841 3656366 SGTC_879 0831-1030 162 µM -0.669797016043669 0.319856011714581 no 2301 0.251493598019938 829 1549252 SGTC_1895 st058434 18.3 µM -0.670896447074989 0.319588692228081 no 2302 0.251143249948713 846 5393175 SGTC_1774 st048371 48.465 µM -0.67273062844703 0.319142931611346 no 2303 0.25055933915697 831 4242727 SGTC_1668 st014914 51.6 µM -0.67295281975787 0.319088950251848 no 2304 0.250488653530852 832 2839556 SGTC_1766 st045414 44.774 µM -0.674263973312041 0.31877048375173 no 2305 0.250071752067006 842 253960 SGTC_1790 st045711 43.5 µM -0.675731995188021 0.318414074208617 no 2306 0.24960540907884 785 585119 SGTC_2370 9071495 200 µM -0.678916315861828 0.317641555647563 no 2307 0.248595443540976 842 21791103 SGTC_889 0919-1524 82.7 µM -0.680847011281139 0.317173553573227 no 2308 0.247984149931538 831 3905452 SGTC_3123 9126162 49.47 µM -0.681478453126789 0.317020554959327 no 2309 0.247784398056338 811 25239884 SGTC_643 k048-0106 28.4 µM -0.681634485547452 0.316982753059389 no 2310 0.247735051614328 839 6763920 SGTC_1261 0712-0010 12.7 µM -0.683547964286441 0.316519330928659 no 2311 0.247130326384739 832 2840123 SGTC_2368 9071271 200 µM -0.6837962228307 0.316459226702937 no 2312 0.247051926032518 841 27209959 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.685265649864647 0.316103572789102 no 2313 0.246588151761702 844 688801 SGTC_573 3702-0553 84.7 µM -0.686663540371868 0.315765391139204 no 2314 0.246147388764568 820 1222756 SGTC_2492 derrusnin 100 µM -0.686928464994369 0.315701317190552 no 2315 0.246063904143778 847 1715307 Part of coumarin class of compounds. SGTC_1956 st077085 54 µM -0.68805331808737 0.315429324985145 no 2316 0.245709602979455 857 24208685 SGTC_1803 st050068 52.4 µM -0.690693868791504 0.314791226442839 no 2317 0.244878971597204 845 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2521 angolensin 13.4 µM -0.69122268085574 0.314663503464616 no 2318 0.244712806327354 842 821428 A flavenoid. SGTC_482 fipronil 114 µM -0.692665609229903 0.314315108526034 no 2319 0.244259713060025 829 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_676 falcarinol 140 µM -0.695730496270678 0.313575640674061 no 2320 0.243298811672826 853 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_43 0570-0105 72.5 µM -0.697670372481058 0.313107991714506 no 2321 0.242691680371595 828 1114046 YDL195W SEC31 SGTC_984 1492-0255 2.91 µM -0.69819928062748 0.312980539106451 no 2322 0.242526288153862 831 1585198 SGTC_1762 st045503 25.4615 µM -0.701345154003053 0.312222930566735 no 2323 0.24154382041075 835 4645554 SGTC_1745 st081495 74 µM -0.70181436154255 0.31211000103659 no 2324 0.241397470622046 824 13842402 YBL026W LSM2 SGTC_2825 7998094 58.44 µM -0.70189784492846 0.312089909987615 no 2325 0.241371436498731 825 2987815 SGTC_1039 k821-0043 94 µM -0.702265284461708 0.31200148890967 no 2326 0.241256869365003 817 15992768 SGTC_1705 st027868 56.3335 µM -0.70261267193447 0.311917903143774 no 2327 0.241148581619065 840 292948 SGTC_158 k038-0087 26.446 µM -0.703512676294935 0.311701395908988 no 2328 0.240868154884181 814 X158 SGTC_2586 curcumin 80 µM -0.706918425943426 0.31088269001854 no 2329 0.239808586316618 841 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2401 5128683 200 µM -0.709259189113097 0.310320537522958 no 2330 0.239081824521432 846 708373 SGTC_2153 5569715 200 µM -0.710395542613529 0.310047792976579 no 2331 0.238729443257264 833 2054701 SGTC_540 1187-0821 17.3 µM -0.710646742423285 0.309987514762385 no 2332 0.238651584997137 837 847520 SGTC_2440 5628896 157.78 µM -0.713885797042781 0.309210725183779 no 2333 0.237648900264634 856 5522048 SGTC_1359 1582-0056 520 nM -0.715887373492985 0.308731133130011 no 2334 0.237030447792922 851 3661189 SGTC_858 0438-0351 2.77 µM -0.715893531687473 0.30872965808518 no 2335 0.237028546383278 841 2799119 SGTC_277 nystatin 15.5 µM -0.716636487527016 0.308551723838895 no 2336 0.236799212194084 854 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1133 3473-0247 50 µM -0.716888783256159 0.308491310482295 no 2337 0.236721361792588 828 711311 SGTC_2176 5809774 33.9695 µM -0.717756989456982 0.30828345419717 no 2338 0.236453568701298 819 2870539 SGTC_2746 daunorubicin 9.88 µM -0.718836655833184 0.308025058195764 no 2339 0.236120784697578 802 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1581 himbacine 57.9 µM -0.719193802585931 0.307939603381005 no 2340 0.236010758688529 862 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1048 3161-0300 24.5 µM -0.720696510588977 0.307580163259795 no 2341 0.235548129889753 833 2165101 SGTC_3204 9114183 49.47 µM -0.721176292065387 0.307465440841065 no 2342 0.235400528170881 830 17027248 SGTC_1007 4101-0031 70 µM -0.728197917126441 0.305788631899527 no 2343 0.233246220354647 871 1146276 SGTC_1936 st074407 74.3 µM -0.730211493850011 0.305308525071633 no 2344 0.232630458973278 857 809813 SGTC_283 0987-0079 11.7 µM -0.731888388417485 0.304908950396319 no 2345 0.232118347002449 834 411556 SGTC_1519 esterone 74 µM -0.732467097063527 0.304771108184421 no 2346 0.231941759152536 850 698 A steroid. SGTC_2939 9044578 71.43 µM -0.733007587605096 0.304642394139252 no 2347 0.231776900807167 858 2653634 SGTC_2594 a-mangostin 100 µM -0.734489397473457 0.304289635540207 no 2348 0.231325259858375 860 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2398 5228213 48.84 µM -0.737468871979565 0.303580895182491 no 2349 0.230418633077833 847 80771 YMR134W ERG29 SGTC_340 k038-0059 454 µM -0.739108201240872 0.303191255527466 no 2350 0.229920648611536 852 23733424 SGTC_74 000s-0487 160.283 µM -0.743580134151764 0.302129494845273 no 2351 0.228565262675116 823 677548 SGTC_1742 st038235 28.8875 µM -0.744427699190599 0.301928447751331 no 2352 0.228308883342002 858 564103 YBR002C RER2 SGTC_2341 7987486 176.74 µM -0.744620436549736 0.301882737777831 no 2353 0.22825060492314 828 1258686 SGTC_3131 9127911 49.47 µM -0.74682364065943 0.30136044262733 no 2354 0.227585011711307 834 45595681 SGTC_1336 1486-0901 104 µM -0.749288219030895 0.300776668255011 no 2355 0.226841753474451 837 5006114 SGTC_248 streptozotocin 5.23457 mM -0.752330219747426 0.300056826671663 no 2356 0.225926249445449 863 5300 DNA alkylating agent. SGTC_727 3032-0951 202 µM -0.755663113236135 0.299269045842108 no 2357 0.224925602613568 859 3652836 SGTC_2722 naftopidil 47.16 µM -0.756250070058913 0.299130406767812 no 2358 0.224749638946292 868 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1240 0356-0016 42.1 µM -0.756489204459513 0.299073931633485 no 2359 0.224677971279745 820 4305613 SGTC_1089 terbinafine 2.25 µM -0.757884424627978 0.298744526261402 no 2360 0.224260087646339 863 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_555 4296-0685 37 µM -0.758999554949813 0.298481367514525 no 2361 0.22392641150813 870 2908540 YHR072W ERG7 SGTC_3281 9140613 49.47 µM -0.759477946213069 0.298368504666063 no 2362 0.223783350858647 842 16013766 SGTC_1033 k072-0102 21.3 µM -0.760670285413449 0.298087290630049 no 2363 0.223427013655555 852 5965931 SGTC_2314 7727897 200 µM -0.763774320559452 0.297355768799677 no 2364 0.222500871180982 833 900724 SGTC_3111 9122088 49.47 µM -0.764095222210999 0.297280189338671 no 2365 0.222405249652096 855 16876704 SGTC_1707 st032323 6.317 µM -0.768071071307861 0.296344517669112 no 2366 0.221222481201212 855 3132057 YMR211W DML1 SGTC_571 k831-0106 44.2 µM -0.768783239515844 0.296177059532479 no 2367 0.221011000141512 858 4783639 SGTC_1054 3429-0080 167 µM -0.770089997917932 0.295869903336907 no 2368 0.220623254357133 868 1162877 SGTC_247 mechlorethamine 29.705 µM -0.771018099441205 0.29565184009467 no 2369 0.220348101769439 843 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1323 1348-1351 11.2 µM -0.771605075343332 0.295513964589838 no 2370 0.220174183678796 838 6989654 SGTC_96 0929-0093 37.281 µM -0.773482563397971 0.295073157734674 no 2371 0.219618422063748 876 6991579 SGTC_1176 0848-0131 83.3 µM -0.775204526403019 0.294669132353357 no 2372 0.219109406977245 870 6769040 SGTC_1554 st069299 38.7 µM -0.775966050367186 0.294490536864282 no 2373 0.218884515754931 828 24207999 SGTC_759 3486-0358 89.3 µM -0.778397024989799 0.293920750036222 no 2374 0.218167496042449 868 875103 SGTC_2310 7668677 200 µM -0.779661229982116 0.293624639519132 no 2375 0.217795152477813 866 2197143 SGTC_2919 7978188 46.38 µM -0.780373076941776 0.293457966779084 no 2376 0.217585655141938 839 2980291 SGTC_3193 9111931 49.47 µM -0.782400762291859 0.292983442365171 no 2377 0.216989542979804 906 17087244 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.784670526694513 0.292452688669622 no 2378 0.216323383801438 863 1241132 A phosphatase inhibitor. SGTC_1422 4031-0024 15.5 µM -0.785520740016203 0.29225399291738 no 2379 0.21607415754029 892 782427 SGTC_1227 3909-8010 46.6 µM -0.785784704563659 0.292192316900743 no 2380 0.215996814455625 856 15982272 SGTC_292 k038-0015 474 µM -0.786767820196231 0.2919626626222 no 2381 0.215708897233231 876 46368540 SGTC_2289 7946404 165.07 µM -0.7881593686307 0.29163774283646 no 2382 0.215301746134044 857 1246120 YPR165W RHO1 SGTC_923 1900-2434 73.3 µM -0.788830302050829 0.291481143402659 no 2383 0.215105598165839 880 5910570 SGTC_929 2805-0021 398 µM -0.790118858546593 0.291180497501359 no 2384 0.214729178648303 914 3098024 SGTC_111 0083-0039 52.457 µM -0.791783548319033 0.290792306710372 no 2385 0.214243448323501 840 759313 SGTC_3190 9110366 49.47 µM -0.792673206768229 0.290584945563018 no 2386 0.213984122266432 854 17123768 SGTC_2037 5169046 200 µM -0.794263367241228 0.290214484195816 no 2387 0.213521062707385 860 5718022 SGTC_812 4251-0442 148 µM -0.794546651315671 0.290148510432128 no 2388 0.213438630848679 890 5723007 SGTC_2249 haloperidol 116.36 µM -0.795418374667008 0.289945539693442 no 2389 0.213185087458425 865 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3181 9108277 49.47 µM -0.797832398758101 0.289383809758447 no 2390 0.212483878621147 884 17097298 SGTC_1426 4048-4480 71.7 µM -0.797941789297303 0.289358367304518 no 2391 0.212452135565981 872 14224343 SGTC_348 k064-0012 10.7 µM -0.798054047879202 0.289332258883448 no 2392 0.2124195631399 870 5066323 SGTC_2057 5236571 38.335 µM -0.798469782832271 0.289235579408083 no 2393 0.212298960840965 875 54684039 YBR257W POP4 SGTC_237 nikkomycin 200 µM -0.798689497896552 0.289184490639177 no 2394 0.21223523894179 894 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_905 2-aminofluorene 215 µM -0.799811432579108 0.288923681376394 no 2395 0.211910029092542 868 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2315 7733312 200 µM -0.799986458004732 0.28888300427364 no 2396 0.211859321606283 876 726316 SGTC_2387 9077560 195.08 µM -0.801539683940086 0.288522142114441 no 2397 0.21140963991555 878 5303272 SGTC_2520 obtusaquinone 4.71 µM -0.803511555287672 0.288064321991603 no 2398 0.21083956030567 867 5967872 SGTC_872 0588-0139 234 µM -0.806127200483538 0.287457562946235 no 2399 0.210084754635396 854 2047100 SGTC_2158 5657123 3.6195 µM -0.808007633749323 0.2870217270076 no 2400 0.209543093823441 894 2858827 SGTC_438 sphingosine 6.67 µM -0.810226527491906 0.286507847558232 no 2401 0.208904996888537 871 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.811541901739451 0.286203422796026 no 2402 0.20852727002909 864 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1655 st012546 55.1 µM -0.813156766501396 0.285829895397959 no 2403 0.208064091670828 878 720985 YLR208W SEC13 SGTC_2898 9056270 58.44 µM -0.817674888292485 0.284786061593333 no 2404 0.206771426552284 816 19154699 SGTC_1263 0774-1208 64.8 µM -0.818763985936704 0.284534716808822 no 2405 0.206460541042129 881 906585 SGTC_818 4072-2707 53.5 µM -0.822878224689413 0.283586179402247 no 2406 0.205288623400571 885 882871 SGTC_1526 st051518 75 µM -0.823381094720415 0.2834703467423 no 2407 0.205145655233998 886 673993 SGTC_732 3970-1727 52.7 µM -0.823718521400361 0.283392635538025 no 2408 0.205049756520746 870 1275699 SGTC_837 0091-0265 12.5 µM -0.82747193725666 0.282528892823251 no 2409 0.203984810770706 887 759367 SGTC_3318 9139014 38.6185 µM -0.827721223819918 0.282471571410763 no 2410 0.203914198318408 895 16643984 SGTC_2965 9082772 38.63 µM -0.830824682741665 0.281758424941622 no 2411 0.20303633836407 804 16459634 SGTC_1135 dihydrocapsaicin 536.708 nM -0.834775393915671 0.280851845165417 no 2412 0.201922091272819 908 107982 A Capsaicinoid. SGTC_2649 anisomycin 9.56 µM -0.836971061840312 0.280348610053981 no 2413 0.201304417184832 877 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_422 cantharidin 155 µM -0.839503176076823 0.279768805973292 no 2414 0.200593503834024 890 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_216 k038-0035 28.382 µM -0.841649898040568 0.2792777052346 no 2415 0.199991975137388 881 4444231 YPR107C YTH1 SGTC_932 2857-0803 154 µM -0.843883384495975 0.278767200644558 no 2416 0.199367286917409 897 674898 SGTC_3305 9127027 53.8275 µM -0.843988345510252 0.278743221044587 no 2417 0.199337959096542 884 41905295 SGTC_325 2810-4341 181 µM -0.84616089839246 0.278247100951743 no 2418 0.198731495896425 863 774970 SGTC_2863 9028737 58.44 µM -0.847824316623079 0.277867537128778 no 2419 0.198267909329787 881 6460917 SGTC_2407 paclitaxel 400 µM -0.848928592346573 0.277615699812171 no 2420 0.197960513860096 927 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2991 9074669 71.4286 µM -0.849019571765594 0.277594956332443 no 2421 0.197935200905931 869 17333109 SGTC_668 1682-0499 62.6 µM -0.849355352635115 0.277518404214541 no 2422 0.197841794440519 889 682214 SGTC_2638 epoxomicin 18 µM -0.851702268346969 0.27698363705589 no 2423 0.197189680660039 875 9915668 A protesome inhibitor. SGTC_660 4031-1742 102 µM -0.851960284773324 0.276924876342122 no 2424 0.197118067671971 863 6738706 SGTC_153 4077-0274 519.67 µM -0.852019884991715 0.276911303844041 no 2425 0.197101527747011 883 3121976 SGTC_1192 1488-0095 21.4 µM -0.852828502693291 0.276727193052911 no 2426 0.196877207612199 919 915875 SGTC_2851 9015922 71.43 µM -0.854823826033175 0.276273142955655 no 2427 0.19632434294119 887 2996893 SGTC_49 0717-0965 32.132 µM -0.856522001394887 0.275886999165554 no 2428 0.19585455424832 901 5889349 YGL099W LSG1 SGTC_705 1124-0212 310 µM -0.857951062475273 0.275562254165643 no 2429 0.19545974326432 885 9554485 SGTC_2347 9049783 174.81 µM -0.85842341757772 0.275454955838078 no 2430 0.195329350672942 912 6467988 YPL169C MEX67 SGTC_3313 9133968 57.047 µM -0.858609180579973 0.275412764276572 no 2431 0.195278085684722 887 1494643 SGTC_977 1348-1378 135 µM -0.858843001659254 0.275359662008478 no 2432 0.195213569738542 870 X977 SGTC_761 k216-0224 480 µM -0.858902417785167 0.275346169027722 no 2433 0.195197177696584 913 1340404 SGTC_620 0109-0052 432 µM -0.861298782600881 0.2748022429327 no 2434 0.194536753010888 904 493037 SGTC_2610 ononetin 44.17 µM -0.86219046745756 0.274599983899839 no 2435 0.194291357232449 920 259632 SGTC_2338 7999974 200 µM -0.86441212879948 0.274096368674474 no 2436 0.193680766198652 892 315925 SGTC_1010 4112-3296 15.2 µM -0.865381238425705 0.273876829996154 no 2437 0.193414787544204 909 704384 SGTC_345 1362-0200 395 µM -0.86582429729678 0.273776489967705 no 2438 0.193293261324211 915 1419823 SGTC_2362 9071156 126 µM -0.866095770968192 0.273715018011627 no 2439 0.193218822083196 912 653133 SGTC_3311 9131146 2.8755 µM -0.866523480287075 0.273618182221655 no 2440 0.193101577866151 892 4900406 YPR165W RHO1 SGTC_2204 7233102 200 µM -0.872938855579071 0.272167742551499 no 2441 0.191348203053013 876 2172480 SGTC_1079 idarubicin 2.36 µM -0.87324539914466 0.272098532502328 no 2442 0.191264667158102 905 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_429 1112-0049 25.5 µM -0.875156189357468 0.271667320104425 no 2443 0.190744463660764 903 2836170 SGTC_765 1319-0117 244 µM -0.875597337018812 0.271567813663182 no 2444 0.190624486802244 869 3487746 YGL099W LSG1 SGTC_1815 st051655 58.2 µM -0.876419483298226 0.271382416605201 no 2445 0.190401015181909 900 5984156 SGTC_2478 5763493 32.33 µM -0.876491906063659 0.271366088023934 no 2446 0.190381337307777 877 1365576 YLR208W SEC13 SGTC_1127 asiatic acid 681.4 nM -0.87860194827182 0.27089056871909 no 2447 0.189808569536067 914 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1275 0867-0008 21.1 µM -0.878841249282989 0.270836666086774 no 2448 0.189743678605929 897 3422836 SGTC_3011 9081274 71.4286 µM -0.881390203540055 0.270262845710665 no 2449 0.189053329086931 917 6625322 SGTC_1255 0566-0045 221 µM -0.885130614941969 0.269421906577678 no 2450 0.188043094599928 900 2788469 SGTC_2930 9013230 14.89 µM -0.885507572913603 0.269337229703135 no 2451 0.187941468517741 863 2995857 SGTC_899 1083-0020 478 µM -0.88773390711378 0.268837395803973 no 2452 0.187341951170803 909 767123 SGTC_1310 1188-0297 994 nM -0.88811160274303 0.268752645666332 no 2453 0.187240361007375 883 1588352 SGTC_1648 st011736 69.8 µM -0.888483985961361 0.268669100707977 no 2454 0.187140233098171 909 2855514 SGTC_2130 NSC 7 2.4545 µM -0.889198175287202 0.268508907352565 no 2455 0.186948291659523 894 21448 SGTC_2164 5685496 200 µM -0.890091838631524 0.268308525456558 no 2456 0.186708287447674 926 759046 SGTC_1560 lithocholic acid 53.1 µM -0.890107899049687 0.268304924993301 no 2457 0.186703975971591 864 9903 A bile acid which acts as a detergent. SGTC_72 0744-0168 198.391 µM -0.891697841806736 0.267948608134775 no 2458 0.186277455324833 929 677577 SGTC_3155 9099265 49.47 µM -0.89277000693709 0.267708463320023 no 2459 0.185990175672876 890 25236499 SGTC_2002 4023503 131 µM -0.896500216985709 0.266873812447157 no 2460 0.184992832233305 910 4736863 YCR052W RSC6 SGTC_586 0957-0265 8.15 µM -0.896675801762459 0.266834557005835 no 2461 0.184945968297422 880 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1841 st054148 70 µM -0.897004184812525 0.266761148327313 no 2462 0.18485834199212 921 675442 SGTC_1241 0364-0022 50.8 µM -0.897877260265988 0.266566025560374 no 2463 0.184625494542247 923 4563895 SGTC_2291 7917025 104.35 µM -0.900092033314238 0.266071372110358 no 2464 0.184035637653548 895 2964612 SGTC_749 1000-0129 128 µM -0.901604275941365 0.265733890996032 no 2465 0.183633559387419 921 708470 SGTC_1449 4112-4002 201 µM -0.902442288501365 0.265546968591789 no 2466 0.183410982734686 903 2059539 SGTC_2745 rifampicin 24.3 µM -0.903103786945298 0.265399465558606 no 2467 0.183235407170426 859 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2213 7173844 200 µM -0.905351303459125 0.26489861797791 no 2468 0.182639652583346 913 892728 SGTC_288 1315-0019 35.1 µM -0.906034488903565 0.264746468850171 no 2469 0.18245879896069 903 6811474 SGTC_114 0364-0001 490.298 µM -0.908357875047471 0.264229370804996 no 2470 0.181844587101583 906 4003655 SGTC_1616 st002734 56.1 µM -0.908671112156556 0.264159695416891 no 2471 0.181761878582029 904 4026101 SGTC_1198 1612-1005 86.7 µM -0.909984335904998 0.263867688329535 no 2472 0.181415385355778 917 6998509 SGTC_117 lucigenin 22.078 µM -0.911515603011225 0.263527405284635 no 2473 0.181011884123231 940 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_781 4335-2806 94.4 µM -0.913883847112075 0.263001567925027 no 2474 0.180388941069842 955 845254 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.916927217908255 0.262326615900933 no 2475 0.179590390134469 925 91467 include heat shock SGTC_3279 9140807 49.47 µM -0.917503679393794 0.262198869558175 no 2476 0.179439382875989 923 45595718 SGTC_1463 k081-0032 34.1 µM -0.919125759457353 0.26183958074871 no 2477 0.179014898549778 866 977755 SGTC_2713 st079149 53.4 µM -0.920014585921381 0.261642813889619 no 2478 0.178782568538494 887 3103253 SGTC_2335 9018011 154.17 µM -0.920440609364889 0.261548528469633 no 2479 0.178671277757304 899 6458208 SGTC_1116 jasmonic acid  1.58368 µM -0.924790539976515 0.260586822380316 no 2480 0.177537436179079 901 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.925965343011968 0.260327403161491 no 2481 0.177231995655439 923 521171 SGTC_1883 5-benzylidenerhodanine 20 µM -0.927519839345567 0.25998434494062 no 2482 0.176828347979441 884 1273210 SGTC_417 st075190 100 µM -0.92798220826613 0.25988235081123 no 2483 0.176708399347227 909 222757 SGTC_2768 sulfasalazine 50.2 µM -0.928385009388165 0.259793513590982 no 2484 0.176603945846168 910 5384001 An antioxidant and salicylic acid derivative. SGTC_2815 7968870 71.43 µM -0.928977889083435 0.25966278332078 no 2485 0.176450272633617 931 2977326 YHR190W ERG9 SGTC_473 2-arachidonoylglycerol 10 µM -0.929035409136658 0.259650101927491 no 2486 0.176435368055403 890 5282280 An endocannabinoid. SGTC_1499 4480-0877 67.3 µM -0.929556678632011 0.259535192699448 no 2487 0.176300333181508 893 2861909 SGTC_2238 6671620 73.2395 µM -0.930567265963669 0.259312492531539 no 2488 0.176038726860489 893 729941 SGTC_1569 carminic acid 40.6 µM -0.930860896685033 0.259247804508095 no 2489 0.175962762062867 888 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2588 indole-3-carbinol 100 µM -0.93088066172435 0.25924345049041 no 2490 0.175957649422642 914 3712 Induces cell cycle arrest. SGTC_1980 st071811 45.7 µM -0.932343749951313 0.258921253449213 no 2491 0.175579452314927 906 4974850 SGTC_1821 st053465 65.6 µM -0.933073926648555 0.258760533580121 no 2492 0.175390900069745 923 675086 SGTC_1220 1838-0075 193 µM -0.934548021048415 0.258436226704516 no 2493 0.175010638597182 898 5529645 SGTC_653 0203-0016 55.2 µM -0.935579325773582 0.258209460644322 no 2494 0.17474491160737 921 295302 SGTC_533 1222-0222 6.71 µM -0.936437210362828 0.25802090528868 no 2495 0.174524063470214 930 3982874 SGTC_1524 corynanthine 62.1 µM -0.936843427869339 0.257931647236628 no 2496 0.174419551389596 943 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_784 4579-0127 173 µM -0.938442175018188 0.257580510653182 no 2497 0.174008610241646 928 1948547 SGTC_2801 7907800 81.82 µM -0.938665702977335 0.257531436472013 no 2498 0.173951203817188 895 6620925 SGTC_1315 1237-0019 3.69 µM -0.938812287743726 0.257499257329703 no 2499 0.173913564473151 904 825140 SGTC_1831 st055328 12 µM -0.939669082461102 0.257311210550659 no 2500 0.173693664388062 910 1103068 SGTC_890 0929-0006 47.2 µM -0.940502710606307 0.257128316831079 no 2501 0.173479879962338 917 1378169 SGTC_1713 st033146 12.748 µM -0.940618737999175 0.257102866379218 no 2502 0.173450137951956 925 674619 SGTC_2078 5212016 200 µM -0.940623330526929 0.257101859041414 no 2503 0.173448960788042 898 1899708 SGTC_1608 st001473 40.5 µM -0.940852416691143 0.257051613250216 no 2504 0.173390247516701 924 7292267 SGTC_1317 1273-0028 910 nM -0.945672335409904 0.255995639061262 no 2505 0.172157868489648 898 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1736 st036774 51 µM -0.94573437342848 0.25598206219975 no 2506 0.172142042849016 922 1272247 SGTC_2218 6965428 192.983 µM -0.946147869566461 0.255891579226246 no 2507 0.172036585421801 901 675684 SGTC_748 act1.228 77.9 µM -0.947065723901658 0.255690790120164 no 2508 0.171802644654737 907 4421505 YNR035C ARC35 SGTC_700 3453-2283 142 µM -0.94737308725645 0.255623569941873 no 2509 0.171724349965171 910 565664 SGTC_67 0335-0847 266 µM -0.947569025040722 0.255580723285524 no 2510 0.171674450616641 941 4552207 YOR254C SEC63 SGTC_2046 4110841 106 µM -0.949150922143257 0.255234939694572 no 2511 0.171271929225912 910 44119630 YMR134W ERG29 SGTC_542 3381-0244 89.3 µM -0.950516312167054 0.254936678727409 no 2512 0.170924984697188 952 1112843 SGTC_1618 st003135 44.5 µM -0.950556229059593 0.254927961875048 no 2513 0.170914848615804 925 1270615 SGTC_1170 0310-0127 64.8 µM -0.95321728869248 0.254347204880993 no 2514 0.17023999424617 930 774975 SGTC_503 tyrphostin 8 294 µM -0.954207574847088 0.254131259293824 no 2515 0.169989290560076 949 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.954882228063094 0.253984196923464 no 2516 0.169818629022022 905 2724278 An inhibitor of dopamine biosynthesis. SGTC_215 1287-0124 461.5 µM -0.955092411511543 0.253938389804487 no 2517 0.16976548307802 927 5560863 SGTC_2843 9000894 45.46 µM -0.956902861352134 0.253544002200181 no 2518 0.169308143424715 870 2242070 SGTC_1758 st042942 75.2445 µM -0.957200880400531 0.253479112719855 no 2519 0.16923293639326 907 669317 SGTC_1015 4130-4525 82 µM -0.957980118381592 0.25330948579439 no 2520 0.169036392029178 924 1363237 SGTC_376 3970-0862 59.1 µM -0.958430620316574 0.253211446374906 no 2521 0.168922830468649 928 3135186 SGTC_2411 st077133 39.94 µM -0.95896391650758 0.253095414847605 no 2522 0.168788461674481 948 1403142 YNL221C POP1 SGTC_2376 9072922 81.32 µM -0.960255415666662 0.252814533792942 no 2523 0.168463341439699 933 17087968 SGTC_3032 9089427 49.47 µM -0.961055530371506 0.252640603604685 no 2524 0.168262123802532 868 17173707 SGTC_2899 9053889 58.44 µM -0.963110368349796 0.252194208646695 no 2525 0.16774606953266 906 6470052 SGTC_3235 9132602 49.47 µM -0.96716007366973 0.251315666008809 no 2526 0.166732009060609 917 4912240 SGTC_3080 9117754 49.47 µM -0.968528443970413 0.251019178049044 no 2527 0.166390260263302 912 9550191 SGTC_2056 5235370 200 µM -0.970085975471272 0.250681929449085 no 2528 0.16600181949214 935 5511916 SGTC_332 4112-0506 40.9 µM -0.97013920149596 0.250670408786198 no 2529 0.165988555543686 917 2790355 SGTC_797 k781-0471 270 µM -0.971271599465525 0.250425370051734 no 2530 0.165706523770165 906 23738129 SGTC_1949 st076024 69.1 µM -0.97304333501703 0.250042240393326 no 2531 0.16526588242346 923 2921930 SGTC_2127 5253358 187.912 µM -0.974893786787922 0.249642420987556 no 2532 0.16480647420971 924 20612 SGTC_2897 9048598 12.99 µM -0.976352307910328 0.249327523876812 no 2533 0.164444953413046 924 6467404 SGTC_1776 st049249 45.9 µM -0.978393301251024 0.248887224805133 no 2534 0.163939920016178 933 1822314 SGTC_938 3126-1755 342 µM -0.978834561122884 0.248792087209601 no 2535 0.16383086496256 906 1777771 SGTC_487 nimodipine 119 µM -0.978865609990796 0.248785393664471 no 2536 0.163823193171759 920 4497 L-type voltage-gated calcium channels inhibitor SGTC_1919 st067113 52.3 µM -0.983689033166713 0.247746720850941 no 2537 0.162634216831834 938 1268243 SGTC_2816 7982706 58.44 µM -0.984770486035228 0.247514159673765 no 2538 0.162368410486087 938 2981853 SGTC_2421 5690543 90.72 µM -0.986044597201133 0.247240317998923 no 2539 0.162055614385323 935 3397993 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.986117626143648 0.247224626972724 no 2540 0.162037697576318 935 676296 Flavone; oxidizing agent. SGTC_3291 9121177 71.43 µM -0.987915772719264 0.246838444547004 no 2541 0.161596950047707 928 17015612 SGTC_199 4063-0024 41.6 µM -0.990706318996119 0.246239767473818 no 2542 0.160914502315709 924 306215 SGTC_2678 equilin 100 µM -0.993001692507568 0.245747907748824 no 2543 0.16035456483371 876 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_275 trichlorophene 5.69 µM -0.995274016454565 0.245261507206105 no 2544 0.159801505782387 900 62616 SGTC_3271 9137798 49.47 µM -0.995415309057295 0.245231280028388 no 2545 0.159767157950282 866 6498326 SGTC_1216 1165-0504 9.65 µM -0.99561016108874 0.245189597996982 no 2546 0.159719797896729 941 6304004 SGTC_2572 astragaloside iv 100 µM -0.996902236241307 0.244913298433757 no 2547 0.15940598306319 922 45006101 An anti-inflammatory agent. SGTC_866 0495-0101 262 µM -0.997071865822184 0.244877036999844 no 2548 0.159364814003307 916 635694 SGTC_649 1123-0311 367 µM -1.0020277792193 0.24381889610135 no 2549 0.158165088202586 915 693629 YIL048W NEO1 SGTC_2995 9067767 71.4286 µM -1.0035917148434 0.243485491979892 no 2550 0.157787724846624 941 11673567 SGTC_1355 1499-0035 1.68 µM -1.00441767690133 0.243309510535999 no 2551 0.157588666577782 953 1548538 SGTC_1876 myriocin 605 nM -1.00514931813785 0.243153682745086 no 2552 0.157412477661324 925 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2473 5854593 8.94 µM -1.0054889149382 0.243081372440307 no 2553 0.157330742258397 922 2872951 SGTC_192 3455-0609 60.9 µM -1.00584315308716 0.24300595694888 no 2554 0.157245512657231 923 3769639 SGTC_1793 st048256 72.231 µM -1.00648710655002 0.242868894968552 no 2555 0.157090655396578 914 672022 SGTC_833 3852-0053 558 µM -1.00722673250462 0.242711521249809 no 2556 0.15691291471721 960 3123681 SGTC_965 1291-5240 308 µM -1.0079219062113 0.242563656186765 no 2557 0.156745977096395 955 2834598 SGTC_1691 st019933 84.6 µM -1.0104285648473 0.242030889400276 no 2558 0.156145004060477 961 6176082 SGTC_1872 amphotericin b 148 nM -1.01131623153061 0.241842376440893 no 2559 0.155932549893413 919 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3149 9097855 49.47 µM -1.01235802171987 0.241621234072595 no 2560 0.155683450962457 894 25236625 YMR079W SEC14 SGTC_2946 9065502 71.43 µM -1.01244687551465 0.241602378026592 no 2561 0.155662217584585 868 16489101 SGTC_372 0155-0182 15.9 µM -1.01316046972464 0.241450972108034 no 2562 0.15549175935224 845 771486 SGTC_1628 st004252 77.7 µM -1.01390071866884 0.241293965232769 no 2563 0.15531506421211 907 692968 SGTC_1514 1189-1591 158 µM -1.01463249504875 0.241138809935438 no 2564 0.155140521746512 944 767698 YMR146C TIF34 SGTC_1658 st012944 20 µM -1.01512584629629 0.241034237476473 no 2565 0.155022921281271 932 24207260 SGTC_817 1391-0715 46 µM -1.01563855906927 0.240925587216396 no 2566 0.154900767989003 934 1353946 SGTC_2856 9022925 19.48 µM -1.0196062613 0.24008568285592 no 2567 0.153957617148277 942 4944862 SGTC_3050 9093513 49.47 µM -1.02126904527811 0.239734171103052 no 2568 0.153563493952023 910 25236664 SGTC_2147 5545932 89.7195 µM -1.02272874373846 0.239425823153043 no 2569 0.153218058514166 958 797404 SGTC_2707 st078556 66.6 µM -1.02538995676443 0.23886422405008 no 2570 0.152589612563252 912 17250899 SGTC_357 1325-0123 420 µM -1.02625262988499 0.23868232781424 no 2571 0.152386259711983 961 1098503 SGTC_2824 7998404 51.95 µM -1.02687404899727 0.238551347413208 no 2572 0.152239887748631 948 837851 SGTC_2297 7971671 152.32 µM -1.02843566798064 0.238222368928041 no 2573 0.151872468857331 948 909016 SGTC_2416 tofa 880 nM -1.02924948599988 0.238051024509607 no 2574 0.151681226842042 942 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1265 0819-1001 68.8 µM -1.0294069272603 0.238017884012647 no 2575 0.15164424764075 937 3106768 SGTC_3328 9140624 29.0385 µM -1.03015920973187 0.237859567714117 no 2576 0.151467637136892 940 4904392 SGTC_2211 7117706 200 µM -1.03023592387406 0.237843426625911 no 2577 0.151449634935894 932 822771 SGTC_2 0422-0095 29 µM -1.03681871835719 0.236460609118222 no 2578 0.149910175134131 919 6790840 SGTC_1791 st048313 56.1 µM -1.03704694623496 0.236412745830812 no 2579 0.149856989346475 892 1204976 SGTC_1849 st056239 19.2 µM -1.04363852490737 0.235032682821834 no 2580 0.148326330918888 915 5393181 SGTC_729 4092-0585 94.1 µM -1.04624023890205 0.234489195695146 no 2581 0.147725064534059 931 2169061 SGTC_481 bay k-8644 50 µM -1.04665070780379 0.234403514009528 no 2582 0.147630352831077 947 2303 A calcium channel antagonist. SGTC_3026 9090633 49.47 µM -1.04705033457481 0.234320112167607 no 2583 0.147538181927655 932 25236842 SGTC_1381 2324-0066 62.1 µM -1.04888126026541 0.233938209272371 no 2584 0.147116385717092 941 10885928 SGTC_2717 st081029 62.2815 µM -1.05105527775465 0.233485190887162 no 2585 0.146616601261641 927 5292846 SGTC_1917 st066507 28.5 µM -1.052071649167 0.233273568026027 no 2586 0.146383339156247 943 3156428 SGTC_3199 9111318 49.47 µM -1.05489422678387 0.232686426224013 no 2587 0.145736851472137 918 8548020 SGTC_2711 st079103 59.1 µM -1.05493992826448 0.232676926338995 no 2588 0.14572639974603 944 54693780 SGTC_361 000s-0510 1.45 µM -1.05524980261479 0.232612518998786 no 2589 0.14565554614624 933 660 SGTC_2662 daunorubicin 22.37 µM -1.05953084324909 0.231723720330295 no 2590 0.144679045114074 902 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1269 0831-0796 3.05 µM -1.06123823404728 0.231369772739672 no 2591 0.144290823855091 914 927758 SGTC_3341 9147222 25.867 µM -1.06132441083527 0.231351916011663 no 2592 0.144271247875086 944 1939759 SGTC_2566 crystal violet carbinol 226 nM -1.06364021817429 0.230872344567474 no 2593 0.143745857893159 954 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1320 1313-0481 95.3 µM -1.06496884258163 0.230597455750995 no 2594 0.143445014808422 938 6813365 YLR208W SEC13 SGTC_1344 1488-0097 29.1 µM -1.06591834305782 0.230401118764217 no 2595 0.143230278140111 957 747966 SGTC_2148 5546263 113.568 µM -1.06635510693965 0.230310836452948 no 2596 0.143131573649538 967 792097 SGTC_2763 lisinopril 49.32 µM -1.06825305024347 0.229918747443378 no 2597 0.142703190246205 938 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3153 9100258 49.47 µM -1.0686899713988 0.229828538473146 no 2598 0.1426046959599 950 25236848 SGTC_808 0711-0032 135 µM -1.07130579600499 0.229288876646166 no 2599 0.142015977285879 929 4252555 SGTC_1765 st044815 90.4 µM -1.07200481262116 0.229144785303961 no 2600 0.14185893526201 950 645695 SGTC_1979 st071809 45.3 µM -1.07232557646485 0.229078681857837 no 2601 0.141786911396595 959 4976333 SGTC_1788 fluconazole 20 µM -1.07271333469794 0.228998786401077 no 2602 0.141699877773945 924 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2077 5212015 200 µM -1.07609860626206 0.228301934198641 no 2603 0.140941579466503 933 780900 SGTC_2115 tiliquinol 12.7705 µM -1.07746199280633 0.228021620498733 no 2604 0.140636960848299 947 71208 A bioactive hydroxyquinoline. SGTC_1168 k815-0004 80.5 µM -1.07792846553467 0.227925757683211 no 2605 0.140532840489805 959 642433 SGTC_1011 4112-3381 17.4 µM -1.07931777368249 0.227640381274258 no 2606 0.140223046127584 939 2877139 SGTC_80 0159-0065 512.242 µM -1.08334475688008 0.22681434025696 no 2607 0.139327713126844 927 1548079 SGTC_1686 st019653 115.5 µM -1.0850332365911 0.226468492116854 no 2608 0.138953467468945 970 97252 SGTC_2170 morpholine 200 µM -1.08618890416392 0.226231950642725 no 2609 0.138697712656975 952 121171 Reacts with secondary amines. SGTC_746 1095-0025 46.6 µM -1.08995738549374 0.225461590220612 no 2610 0.137865958127697 953 6749286 SGTC_252 miconazole 1.30953 nM -1.09173604372182 0.225098509841471 no 2611 0.137474568807266 930 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_796 1234-0020 70.7 µM -1.09285521137597 0.224870222249153 no 2612 0.137228687942276 912 46495034 SGTC_3144 9087057 49.47 µM -1.09298932180992 0.224842875238986 no 2613 0.137199244078696 944 17249618 SGTC_2999 9069765 71.4286 µM -1.09352922213406 0.224732801019982 no 2614 0.13708075295066 935 2097066 SGTC_2351 9026858 72.31 µM -1.09400214012523 0.224636408190494 no 2615 0.136977019796199 986 1409300 SGTC_845 0330-0138 4.51 µM -1.09940377649127 0.223537081108042 no 2616 0.135795992130818 943 9039800 SGTC_1626 st003712 1.76 µM -1.10033750598633 0.22334736156979 no 2617 0.135592548180788 966 24207035 SGTC_2203 7227154 166.4 µM -1.10076571895814 0.223260385905035 no 2618 0.135499317653687 954 896304 SGTC_1698 5-fluorocytosine 1.055 µM -1.10170424309318 0.223069826801127 no 2619 0.135295135847208 949 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_139 0099-0334 718.624 µM -1.1033472886555 0.222736443897968 no 2620 0.134938189027006 960 97690 SGTC_279 1273-0055 2.93 µM -1.10634220797676 0.222129489558752 no 2621 0.134289214697043 976 2847562 SGTC_184 1494-0393 24.714 µM -1.10743002576056 0.221909264890514 no 2622 0.13405402510223 962 3090647 SGTC_1479 0549-0158 134 µM -1.1083572601316 0.221721648212721 no 2623 0.133853777687839 968 5440202 SGTC_2010 4012422 159 µM -1.11067474505192 0.221253124655177 no 2624 0.133354188353794 945 952393 SGTC_875 0709-0210 25.7 µM -1.11173168563866 0.221039632230628 no 2625 0.133126765981428 964 6251364 SGTC_743 1275-0778 158 µM -1.11200195350407 0.22098505950356 no 2626 0.133068655205625 953 2849257 YMR203W TOM40 SGTC_1087 pterostilbene 9.05 µM -1.112417262368 0.220901215001498 no 2627 0.132979392938646 971 5281727 Similar to reservatol, lowers cholesterol. SGTC_2513 baicalein 25.65 µM -1.11454475602223 0.220471992306218 no 2628 0.132522777561598 980 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1500 4488-1866 171 µM -1.11582878556948 0.220213170283545 no 2629 0.132247714822858 965 2900003 SGTC_519 k048-0011 62.8 µM -1.11834047870623 0.219707392018857 no 2630 0.131710802475073 936 6836379 SGTC_2692 st077426 47.7 µM -1.1193214954737 0.219510026483393 no 2631 0.131501504356619 974 25238571 SGTC_937 3122-0005 46.7 µM -1.11963862062946 0.219446247552333 no 2632 0.131433895419733 948 759535 SGTC_3189 9110682 49.47 µM -1.1204015533287 0.219292853231676 no 2633 0.131271341656571 982 17122418 SGTC_1121 fusaric acid 630.51 nM -1.12239137273876 0.218893072647091 no 2634 0.130848035513178 953 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1004 4084-0029 199 µM -1.12387830309876 0.218594602930276 no 2635 0.130532328480548 956 716894 YLR208W SEC13 SGTC_7 0192-1582 4.227 µM -1.12735057571178 0.217898531022664 no 2636 0.129797143414468 986 252616 SGTC_1955 wogonin 32.4 µM -1.12764337526314 0.21783989322102 no 2637 0.12973528024496 944 5281703 A flavanone. SGTC_444 curcumin 90.4 µM -1.12803272989674 0.217761932816684 no 2638 0.129653048393456 943 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2199 6590217 200 µM -1.12912122298546 0.217544069464939 no 2639 0.129423349793237 904 703109 SGTC_183 3914-0051 30.55 µM -1.13031579124509 0.217305119878427 no 2640 0.129171591457898 959 1596232 SGTC_1740 st038286 13.222 µM -1.13301588643156 0.216765578464499 no 2641 0.128603790987625 938 716786 SGTC_21 0849-0113 22.993 µM -1.13366927825127 0.216635132182664 no 2642 0.128466650515172 961 1560156 SGTC_1284 0929-0043 16 µM -1.13418895771224 0.216531413306056 no 2643 0.128357647445058 968 1239883 SGTC_75 0159-0059 199.013 µM -1.13431354082007 0.216506552979897 no 2644 0.128331525610318 943 5377270 SGTC_753 1322-0200 289 µM -1.1361119650009 0.216147864836579 no 2645 0.127954854050404 964 5403907 SGTC_179 1273-0063 6.77 µM -1.13621649003025 0.216127028346028 no 2646 0.127932985414737 990 3108139 SGTC_1088 bifonazole 369 nM -1.1368316606641 0.216004421030797 no 2647 0.127804332567877 955 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2960 9079389 5.97 µM -1.13777454987129 0.215816575606307 no 2648 0.127607317327699 967 16457355 SGTC_1012 4112-3522 18 µM -1.1381332179298 0.215745145465194 no 2649 0.127532429656007 948 3112398 SGTC_3222 9128301 49.47 µM -1.1418380980588 0.215008106467334 no 2650 0.126760661513582 945 4911358 SGTC_1983 st071813 46.9 µM -1.14223656865513 0.214928922965571 no 2651 0.126677849715261 969 11838595 SGTC_2111 5486399 200 µM -1.14367310787197 0.214643596600588 no 2652 0.126379615006349 932 689674 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.14663513902094 0.21405597146782 no 2653 0.125766223681794 971 6710655 SGTC_58 0957-0393 9 µM -1.14695849120716 0.213991879696249 no 2654 0.125699388334639 966 6997992 SGTC_3342 9147791 14.508 µM -1.1479234530794 0.213800680623068 no 2655 0.12550008266457 955 1838168 SGTC_2950 9072895 21.46 µM -1.14810244240987 0.213765226335311 no 2656 0.125463138016262 938 17332245 SGTC_3100 9120536 49.47 µM -1.14816763145511 0.213752314510378 no 2657 0.125449684427777 951 16421196 SGTC_1909 st060837 51.5 µM -1.14828289625292 0.213729485422827 no 2658 0.125425898767021 955 678937 SGTC_2701 st077767 14.721 µM -1.15052021172752 0.213286649118009 no 2659 0.124964837218532 956 5721188 SGTC_3016 9080866 49.47 µM -1.15067503492447 0.213256024459056 no 2660 0.124932975417808 964 17066299 SGTC_1728 st035614 33.7865 µM -1.15165106346063 0.21306302108173 no 2661 0.124732244534759 947 15945546 SGTC_3040 9091894 49.47 µM -1.15479564302286 0.212441894108625 no 2662 0.12408706087041 930 25236966 SGTC_1851 st056236 18.9 µM -1.1562041825243 0.212164018491781 no 2663 0.123798824722477 930 5393171 SGTC_2430 5571206 200 µM -1.15734073206179 0.211939955834667 no 2664 0.123566589103317 965 1731771 SGTC_1369 1866-0067 208 µM -1.15743243315923 0.211921883651905 no 2665 0.123547864769286 954 3531355 SGTC_2884 9058502 51.95 µM -1.15761971104183 0.211884978277714 no 2666 0.12350963090278 964 6471554 SGTC_1578 josamycin 24.2 µM -1.15854180634499 0.211703323072132 no 2667 0.123321500652996 974 5282165 A P450 substrate. SGTC_3262 9137218 49.47 µM -1.16391493381299 0.210646617273352 no 2668 0.122229243478374 936 17650664 SGTC_575 k072-0246 11.9 µM -1.16469450030657 0.210493561353119 no 2669 0.122071337982542 987 6796779 SGTC_2185 6113692 200 µM -1.16591163949794 0.210254725303187 no 2670 0.121825086247593 974 874150 SGTC_2628 lathosterol 100 µM -1.16600643832466 0.210236129859246 no 2671 0.121805921198516 970 6710616 SGTC_791 1348-1292 225 µM -1.1694914299854 0.209553195351333 no 2672 0.121102846041913 990 5437054 SGTC_3096 9117468 49.47 µM -1.16978466099925 0.209495792074068 no 2673 0.121043819002685 941 41316311 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.17051957939898 0.209351964163492 no 2674 0.120895969784975 932 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1634 st006576 41 µM -1.17316152206494 0.208835400398039 no 2675 0.120365519510146 954 3915356 SGTC_3177 9107506 49.47 µM -1.1758733425781 0.208305955670978 no 2676 0.119822746367166 962 8897194 SGTC_1280 0880-0253 10.1 µM -1.17622455561208 0.208237444241654 no 2677 0.119752577208643 963 6836607 SGTC_730 1436-0052 41.2 µM -1.17888176239573 0.207719531586237 no 2678 0.119222630406538 956 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2100 5377183 190 µM -1.18059269400965 0.207386459257225 no 2679 0.118882283689031 945 2844202 SGTC_772 k072-0172 35.3 µM -1.18148998242138 0.207211907644544 no 2680 0.118704065336455 938 5861980 SGTC_2858 9025781 8.96 µM -1.18350978142266 0.206819309495661 no 2681 0.118303586136385 937 4894980 YPL153C RAD53 SGTC_2175 5807670 165.306 µM -1.18617929423001 0.206301099453092 no 2682 0.117775750699324 926 241186 SGTC_106 0092-0003 11.579 µM -1.18865434537387 0.205821326809321 no 2683 0.117287856509391 964 1072148 SGTC_1879 gemcitabine 100 µM -1.19178164707187 0.205216067256634 no 2684 0.116673436940511 989 60750 A nucleoside analog which inhibits DNA replication. SGTC_2034 5197015 53.07 µM -1.19375932310275 0.20483385328187 no 2685 0.116286063754551 978 780676 SGTC_664 1222-0054 14.9 µM -1.19390679517901 0.204805369179773 no 2686 0.116257214572955 973 6813991 SGTC_1834 st055981 52.8 µM -1.19523271051768 0.204549375615023 no 2687 0.115998060859885 980 471719 YDL150W RPC53 SGTC_2988 9073640 71.4286 µM -1.20095555636434 0.203446656091177 no 2688 0.114884220873935 993 9102229 SGTC_1343 1487-0095 224 µM -1.20123337706789 0.203393213994837 no 2689 0.114830342807544 983 4560101 YGL055W OLE1 SGTC_896 0964-0007 44.5 µM -1.20131387840541 0.203377730176236 no 2690 0.11481473445638 945 6756758 SGTC_1013 4112-3890 241 µM -1.2019721438361 0.203251144229448 no 2691 0.114687160435533 965 705171 SGTC_1234 0326-0494 15.5 µM -1.20217772150661 0.203211620811616 no 2692 0.114647339479113 971 1547813 SGTC_335 4077-0256 27.6 µM -1.20538576705071 0.202595451268238 no 2693 0.114027206720838 950 3121989 SGTC_3297 9117502 71.43 µM -1.20603004601672 0.202471839354832 no 2694 0.113902952764523 971 7453720 SGTC_3089 9117425 49.47 µM -1.20650808304407 0.202380151910096 no 2695 0.113810822164518 993 9401657 SGTC_1368 1852-0141 284 µM -1.21011495272203 0.201689155524664 no 2696 0.113117393130756 991 2838987 SGTC_2182 6325192 200 µM -1.21114376180614 0.20149231779892 no 2697 0.112920155953459 947 736248 SGTC_2052 5265182 7.135 µM -1.21198879627876 0.201330727035807 no 2698 0.112758334679508 960 1239884 SGTC_2888 9058547 12.99 µM -1.21702603076078 0.200369100294011 no 2699 0.111797155986208 957 16476514 SGTC_2471 5466956 24.79 µM -1.21770836204005 0.200239053249161 no 2700 0.111667409126729 960 724419 SGTC_1830 st055982 50.3 µM -1.21937471171478 0.199921673192541 no 2701 0.111351001774157 986 455313 An antimicrobial agent. SGTC_2627 acetyl isogambogic acid 100 µM -1.22163385808468 0.199491869951776 no 2702 0.110923059409426 982 6857789 A caspase activator and apoptosis inducer. SGTC_595 3909-8003 73.7 µM -1.22385576078698 0.199069695304582 no 2703 0.110503322413468 995 699517 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.22443850321878 0.198959059964042 no 2704 0.110393425951879 961 756377 SGTC_1678 st019265 80.2 µM -1.22504689467609 0.198843594627654 no 2705 0.110278776107237 966 5367020 SGTC_780 0109-0199 192 µM -1.22508295341283 0.198836752384008 no 2706 0.110271983610257 960 610414 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.2320242292738 0.197522271068002 no 2707 0.108970016704855 998 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2926 9010726 65.15 µM -1.23220463032543 0.197488178406047 no 2708 0.108936327046367 992 2994293 SGTC_1976 st070609 63.5 µM -1.23536709684516 0.1968911052633 no 2709 0.108346956290576 974 682556 SGTC_2369 9071472 200 µM -1.23568912110658 0.196830368507542 no 2710 0.108287071443441 976 17296037 SGTC_2252 omeprazole 400 µM -1.23593730632391 0.1967835662209 no 2711 0.108240934240488 977 4594 A proton pump inhibitor. SGTC_758 0868-0029 16 µM -1.23629774073503 0.196715608201 no 2712 0.108173955302928 956 762687 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.23858714193687 0.196284285575802 no 2713 0.107749216132683 939 88881 An O-methylated flavonoid and antioxidant. SGTC_3261 9137475 49.47 µM -1.23938718729708 0.19613369251747 no 2714 0.107601072053184 928 17027690 SGTC_1567 st069303 68.4 µM -1.24268902095356 0.195512927890809 no 2715 0.106991225623508 982 5581319 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.24294703434365 0.195464470131394 no 2716 0.10694367596408 1005 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1069 diphenylcyclopropenone 8.49 µM -1.24419901022507 0.195229438848018 no 2717 0.106713163978552 997 65057 A dermal irritant. YDR527W RBA50 SGTC_3354 9151612 71.43 µM -1.24555404680651 0.194975253768423 no 2718 0.106464080908984 967 27261949 SGTC_2997 9067075 71.4286 µM -1.24607431403427 0.194877712717022 no 2719 0.106368556905044 962 27209819 SGTC_2875 9039966 71.43 µM -1.24637259750497 0.194821803143713 no 2720 0.106313818295822 984 6463691 SGTC_1671 st016596 74.5 µM -1.24686929565034 0.194728724827804 no 2721 0.10622271335222 994 2829167 SGTC_298 1391-0729 10 µM -1.24788125989419 0.194539172394074 no 2722 0.106037272223594 984 3237558 SGTC_912 3474-0017 2.18 µM -1.24935334708496 0.194263634262388 no 2723 0.105767931970316 994 3360550 SGTC_2451 5856223 45.7 µM -1.25365372855077 0.193460071956728 no 2724 0.1049839465989 982 2179896 SGTC_2074 5212007 75.395 µM -1.25444246126529 0.193312911004074 no 2725 0.104840613588348 966 758611 SGTC_1837 st055472 66.5 µM -1.2553397845613 0.193145572422529 no 2726 0.104677719237362 989 676091 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.26211187246119 0.19188552425127 no 2727 0.103454266869738 932 4000243 SGTC_2519 cryptotanshinone 88.04 µM -1.26589968812648 0.191182944130056 no 2728 0.102774499043327 981 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3277 9138724 49.47 µM -1.26598096267988 0.191167886285097 no 2729 0.10275994902891 1002 15943418 SGTC_1414 3917-0015 5.4 µM -1.26866555523957 0.190670917000178 no 2730 0.102280186247652 986 6618702 SGTC_1423 4048-0112 5.59 µM -1.26940026055424 0.190535047359236 no 2731 0.102149171655659 981 X1423 SGTC_2079 5212404 121 µM -1.27189995807064 0.190073221637302 no 2732 0.101704333381728 987 758462 SGTC_2914 7968218 45.32 µM -1.27508883668929 0.189485067460178 no 2733 0.101138900079429 961 2977111 SGTC_1498 4478-3555 97.6 µM -1.27632890954139 0.189256652192976 no 2734 0.10091963742399 989 3437919 SGTC_3106 9121286 49.47 µM -1.27675063570368 0.189179010970172 no 2735 0.100845149220174 958 15943471 SGTC_83 0170-0301 39.027 µM -1.28237966467787 0.188144566441115 no 2736 0.0998547470886274 1011 3089716 SGTC_97 0535-0701 19.132 µM -1.28438395632244 0.187777082881743 no 2737 0.0995038218792088 954 2832013 YGL099W LSG1 SGTC_3012 9080433 71.4286 µM -1.28718908354431 0.187263512432346 no 2738 0.09901419561897 986 17688859 SGTC_873 0591-4978 488 µM -1.28730563720632 0.187242192275208 no 2739 0.0989938897416196 998 3305145 SGTC_1610 st001799 48.1 µM -1.29817464343732 0.185260618746824 no 2740 0.0971136646313856 993 621897 SGTC_671 0560-0003 407 µM -1.29837033381903 0.185225061380452 no 2741 0.0970800540995418 993 3238678 SGTC_10 0279-0212 42.575 µM -1.29898122211695 0.185114088921516 no 2742 0.0969751867500466 1009 39851 YBR002C RER2 SGTC_1006 4099-6547 255 µM -1.29912159779829 0.185088594458614 no 2743 0.0969511010946558 1004 3146833 SGTC_2748 diazoxide 86.69 µM -1.30080559646526 0.184782923490379 no 2744 0.0966625029335345 956 3019 A potassium channel activatior. SGTC_2570 licareol 100 µM -1.30580538380109 0.183877237550568 no 2745 0.0958093743730582 993 443158 SGTC_2770 toltrazuril 17.5 µM -1.30933540662511 0.183239459965658 no 2746 0.0952103805525508 962 68591 Kills coccidiodes. SGTC_1835 st008666 49.2 µM -1.30997941803558 0.183123253876793 no 2747 0.0951013992147863 975 690455 SGTC_3058 9093861 49.47 µM -1.31216914399744 0.182728481439733 no 2748 0.0947315352006716 979 17217477 SGTC_1254 0550-0035 264 µM -1.3139650600005 0.18240510351209 no 2749 0.0944289813029733 1001 15121435 SGTC_1057 3448-5381 134 µM -1.31438015248302 0.182330411636081 no 2750 0.094359153098943 943 5497911 SGTC_2288 7946289 167.31 µM -1.3160253157282 0.182034568439069 no 2751 0.0940827729335893 1005 1246052 SGTC_3284 9108171 64.8615 µM -1.31728272775872 0.181808655487064 no 2752 0.0938719363069331 970 8687505 SGTC_558 k064-0027 21.3 µM -1.31760777630705 0.181750284174974 no 2753 0.0938174905443258 985 5088526 SGTC_950 1165-0508 94.1 µM -1.31933181518176 0.181440882122275 no 2754 0.0935291029880014 996 6148369 SGTC_1307 1187-1599 12.2 µM -1.32025899280801 0.181274624007748 no 2755 0.0933742808903815 996 1538471 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.32178554749295 0.181001095710969 no 2756 0.0931197861281134 992 16725076 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.32221079847362 0.180924945256329 no 2757 0.0930489831244008 981 17037758 SGTC_1814 st052110 31.539 µM -1.32318476189212 0.180750611550062 no 2758 0.0928869711039965 995 674163 SGTC_956 1185-0240 191 µM -1.32548935946461 0.180338521771027 no 2759 0.0925044481508372 993 1416193 SGTC_497 capsazepine 133 µM -1.32838485324752 0.179821608995393 no 2760 0.092025500343408 1002 2733484 A calcium channel blocker. SGTC_2298 7976326 193.81 µM -1.33004237678229 0.179526121924599 no 2761 0.0917521547079588 1002 2235818 SGTC_2192 5915882 198.485 µM -1.33008949561483 0.179517726503966 no 2762 0.0917443930456035 992 2876149 SGTC_367 0335-0881 7.1 µM -1.33129935268029 0.179302244161572 no 2763 0.0915452655716114 1017 23828853 SGTC_2648 atorvastatin 78.68 µM -1.33454892637468 0.178724282368306 no 2764 0.0910120117502897 992 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3316 9136639 10.545 µM -1.34021920179101 0.177718592690353 no 2765 0.0900870453381355 976 4903665 SGTC_514 4466-0038 2.65 nM -1.34300528005687 0.177225759848195 no 2766 0.0896351320732762 950 5722064 SGTC_456 gingerol 170 µM -1.34642820980468 0.176621456437019 no 2767 0.089082229164611 1008 442793 A herb. SGTC_1223 0764-0573 147 µM -1.34647835626398 0.176612612992449 no 2768 0.0890741479583194 1000 1609797 SGTC_1962 st076595 64.5 µM -1.34687873106397 0.176542016009319 no 2769 0.0890096462937584 996 279619 SGTC_3241 9133421 49.47 µM -1.34729954431641 0.176467834410795 no 2770 0.0889418894103484 1041 17018221 SGTC_1397 3532-0190 20.1 µM -1.35303599273344 0.175458571603921 no 2771 0.0880220660530138 995 5322280 SGTC_1632 st005650 90 µM -1.35322852166436 0.175424761913337 no 2772 0.0879913180684857 989 2759605 SGTC_639 0833-0042 114 µM -1.35410442045475 0.17527099889861 no 2773 0.0878515330606252 1005 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_847 0342-0274 5.54 µM -1.35827073108244 0.174540778502334 no 2774 0.0871888970173856 1005 18097 SGTC_250 brefeldin a 552.239 µM -1.35914709847868 0.174387425751028 no 2775 0.0870499903928536 1012 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1818 st052136 56.3 µM -1.36000674611649 0.17423708192556 no 2776 0.0869138945491142 963 674169 SGTC_263 alizarin 107.927 µM -1.36140285835657 0.173993091341022 no 2777 0.0866932066597895 1014 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_477 mead ethanolamide 10 µM -1.3637714089157 0.173579650408935 no 2778 0.0863197607077896 1010 16061185 SGTC_3018 9082602 49.47 µM -1.3646812080304 0.173421007286565 no 2779 0.0861766342430577 976 17332089 SGTC_2436 5633522 8.09 µM -1.36573614448378 0.17323717192688 no 2780 0.0860108976146885 1015 5724242 SGTC_2787 5284540 71.43 µM -1.36661031742786 0.173084930837557 no 2781 0.0858737407760678 1013 736958 SGTC_2108 5365811 200 µM -1.36776459300301 0.172884039233927 no 2782 0.0856928869770342 992 780283 SGTC_24 0417-1663 219 µM -1.36820910767633 0.172806714972922 no 2783 0.085623315788217 1031 4329390 SGTC_2928 9011484 9.79 µM -1.36853505283713 0.172750030136835 no 2784 0.0855723288470471 965 2994751 SGTC_777 1315-0167 517 µM -1.37014380022925 0.17247042793189 no 2785 0.0853210087367307 981 4221767 SGTC_1113 artemisinin 1.17947 µM -1.37087105695147 0.172344124635463 no 2786 0.0852075776234841 983 2240 An anti-malaria and mitochondrial poison. SGTC_382 3229-0966 23.2 µM -1.37258993326995 0.172045840526195 no 2787 0.0849399315857487 1017 5722370 SGTC_865 0488-0499 301 µM -1.37422782525567 0.171761916794151 no 2788 0.0846854824617024 984 9634651 SGTC_1108 betulinic acid 729.144 nM -1.37555983632578 0.17153123739808 no 2789 0.0844789742512636 1001 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_19 0279-0214 38.434 µM -1.37637121765062 0.17139081840293 no 2790 0.0843533671162192 1015 3566274 YBR002C RER2 SGTC_262 fenpropimorph 62.5 µM -1.37715060924698 0.171256004810419 no 2791 0.0842328442141286 1036 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2885 9057732 51.95 µM -1.37823561566529 0.171068441072513 no 2792 0.0840652771697308 997 6471414 SGTC_2551 apiole 73.87 µM -1.37922884729025 0.170896857567928 no 2793 0.0839121032332559 996 10659 A possible DNA adduct former. SGTC_2583 asiatic acid 100 µM -1.37935858905939 0.170874452453438 no 2794 0.0838921102380866 1010 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1156 4092-0367 4.88 µM -1.38309756370463 0.170229576351015 no 2795 0.0833174763107858 990 1357585 SGTC_3345 9148410 3.559 µM -1.38340611004349 0.170176429851373 no 2796 0.0832701890615303 973 4903596 SGTC_699 0375-0592 111 µM -1.38923689554551 0.16917408790518 no 2797 0.0823803628969812 984 762578 SGTC_1402 3909-7673 35.9 µM -1.39057455641903 0.168944672792623 no 2798 0.0821772381467369 1019 5328014 SGTC_3195 9113082 49.47 µM -1.39058424167198 0.16894301245539 no 2799 0.0821757688111033 1024 17018038 SGTC_2008 4012253 172 µM -1.39066953051708 0.168928391891269 no 2800 0.0821628306189119 976 603940 SGTC_46 0329-0187a 2.197 µM -1.39262974119053 0.168592588557647 no 2801 0.0818658922826669 1001 46494817 SGTC_5 0352-0601 109.883 µM -1.39371472592048 0.168406904637449 no 2802 0.0817018837805156 993 762456 SGTC_702 1488-0190 94 µM -1.39603889992009 0.16800958906653 no 2803 0.0813513906861835 1000 949357 SGTC_1664 st014217 9.02 µM -1.3963674065936 0.167953479830176 no 2804 0.0813019424197103 977 3982782 SGTC_2959 9079155 11 µM -1.39729300152639 0.167795452256274 no 2805 0.0811627397547414 1011 16189457 SGTC_3098 9119039 49.47 µM -1.39742038791669 0.167773710971454 no 2806 0.0811435958665121 997 17161528 SGTC_100 0086-0128 49.5915 µM -1.39837826821462 0.167610285767962 no 2807 0.0809997527757822 1010 93297 SGTC_821 1114-0266 29.2 µM -1.4021614113204 0.166965841375964 no 2808 0.0804335259896195 997 3123235 SGTC_2348 9022543 33.42 µM -1.40288735301399 0.166842362888766 no 2809 0.0803252163816321 988 3162678 YDL140C RPO21 SGTC_1509 1326-1131 80 µM -1.40667683581132 0.166198750437173 no 2810 0.0797616187901769 992 768313 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.41240413447945 0.165229063736362 no 2811 0.078915499894976 1009 4213774 SGTC_1817 st052116 64.4 µM -1.41259777879367 0.165196342014424 no 2812 0.078887011265654 1017 4361398 SGTC_2847 9005661 71.43 µM -1.41275563504884 0.165169670807646 no 2813 0.0788637934808765 999 2991449 SGTC_1419 3993-2473 62.6 µM -1.41660296555508 0.164520492255787 no 2814 0.0782995205046629 1028 704026 SGTC_403 arphamenine a 50 µM -1.41684275097834 0.164480086927813 no 2815 0.0782644537298966 1013 5487158 An arginine aminopeptidase inhibitor. SGTC_1100 amiodarone 5.07 µM -1.41909177713617 0.164101425212303 no 2816 0.0779361304666933 1006 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_41 0478-0632 82.643 µM -1.42204433330985 0.163605171436809 no 2817 0.0775066906487078 984 3750424 SGTC_597 k018-0003 82.8 µM -1.42696605501087 0.162780116476573 no 2818 0.0767948396137226 1031 6786234 SGTC_2418 pentamidine 31.67 µM -1.42765816278351 0.162664312081703 no 2819 0.076695136865282 952 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1169 aniline yellow 25.8 µM -1.42909393572918 0.162424247589258 no 2820 0.0764886181357139 1005 6051 A DNA damaging agent. SGTC_2125 5246583 200 µM -1.43208046467297 0.161925632216599 no 2821 0.0760603972756272 1028 835267 SGTC_2741 miltefosine 3.04 µM -1.43498749318286 0.161441248561678 no 2822 0.0756453307908224 997 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1829 berberine 14.4 µM -1.43834293122264 0.160883324618481 no 2823 0.0751683882118524 961 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_265 mycophenolic acid 32.932 µM -1.44000148019236 0.160608015535501 no 2824 0.0749334901465908 1037 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2685 mycophenolic acid 18.85 µM -1.44263992651775 0.160170683937007 no 2825 0.0745609649772878 1004 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2055 5235184 200 µM -1.44536507275629 0.159719799579847 no 2826 0.0741776842982312 1004 2836034 SGTC_1779 st039427 55 µM -1.44832701437703 0.159230679431968 no 2827 0.0737628079935447 1011 1124498 SGTC_1318 1280-3875 124 µM -1.44926206975163 0.159076473034836 no 2828 0.0736322046985774 1022 373245 SGTC_405 ebelactone b 50 µM -1.45080852630156 0.158821651060719 no 2829 0.0734165923980615 1004 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_63 0099-0242 26.702 µM -1.45575275983734 0.15800874643168 no 2830 0.0727304895643102 1012 3898502 YLR359W ADE13 SGTC_217 ketoconazole 989 nM -1.45597532874789 0.157972217196157 no 2831 0.0726997199339779 954 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1026 k007-1105 30.6 µM -1.45632637116645 0.157914613450914 no 2832 0.0726512094038513 1003 7066794 SGTC_1521 st012942 49.4 µM -1.4574783230734 0.157725682645269 no 2833 0.0724921953802165 1005 24207259 SGTC_1023 4482-3888 16 µM -1.45885558091528 0.15749999453498 no 2834 0.0723024304956814 1006 3303168 SGTC_1997 st073024 93.8 µM -1.46051614848878 0.157228163436076 no 2835 0.0720741363478435 1023 686268 SGTC_2650 prasterone 100 µM -1.47024778360714 0.155641321779543 no 2836 0.0707473287264724 1016 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2708 st078559 56 µM -1.473077965353 0.155181821583871 no 2837 0.0703650070812427 989 17250902 SGTC_45 0kpi-0036 14.9 µM -1.47438611240612 0.154969737511721 no 2838 0.0701888307385092 1019 2795021 SGTC_539 4859-0462 2.54 µM -1.47491881953738 0.154883426943559 no 2839 0.0701171850245166 994 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1432 4049-0298 68.4 µM -1.47495542442266 0.154877497292781 no 2840 0.0701122639671509 1036 741646 SGTC_3296 9122258 64.045 µM -1.47523560333014 0.154832115883469 no 2841 0.0700746063052256 1001 4730474 SGTC_2045 5106652 78.05 µM -1.47902155389046 0.15421975559862 no 2842 0.0695672771435939 994 673349 SGTC_876 0720-0963 56.8 µM -1.47970875748617 0.154108775536864 no 2843 0.0694754937428664 1027 765861 SGTC_855 0428-0020 25 µM -1.48038101399644 0.154000260489885 no 2844 0.0693857969480019 1012 6812414 SGTC_2670 beta-carotene 100 µM -1.48066740939904 0.153954046160084 no 2845 0.0693476113326676 985 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2541 muurolladie-3-one 83.07 µM -1.48630772005398 0.1530457649293 no 2846 0.0685988728219388 982 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1150 3909-7983 10.9 µM -1.48703650039624 0.152928666250773 no 2847 0.0685025854782057 1021 23965914 SGTC_3048 9093155 49.47 µM -1.48792974294133 0.152785223225521 no 2848 0.0683847114331581 1007 25236002 SGTC_1953 st076800 12.1 µM -1.48976824518143 0.152490264829738 no 2849 0.0681425916697707 1008 297591 SGTC_489 paxilline 115 µM -1.49118921102958 0.152262552554808 no 2850 0.0679559127295226 1025 105008 A toxic potassium channel blocker. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.49624070553993 0.151454870257066 no 2851 0.0672954702666756 997 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.49760100248923 0.151237860436132 no 2852 0.0671184730794909 1018 7104 SGTC_3103 9120822 49.47 µM -1.4998561181727 0.150878554984371 no 2853 0.0668258385082232 1005 17141819 SGTC_531 3788-1495 174 µM -1.5016834241805 0.150587829129798 no 2854 0.0665894433693229 998 2896655 SGTC_1738 st035555 74 µM -1.50290226997393 0.150394117353344 no 2855 0.0664321237914431 1013 5331140 SGTC_2933 9026794 32.47 µM -1.50382513413579 0.15024755657969 no 2856 0.0663131988732292 1009 17586027 SGTC_3167 9103034 49.47 µM -1.50466252768314 0.150114651859565 no 2857 0.0662054308590196 1035 5127859 SGTC_1304 1165-0502 251 µM -1.50851517972026 0.149504198279224 no 2858 0.0657113622975203 1021 767425 SGTC_1472 k841-0093 193 µM -1.51249428960291 0.148875449065085 no 2859 0.0652040821240863 1029 X1472 SGTC_206 4546-0025 72.014 µM -1.51619548083352 0.148292202821656 no 2860 0.0647349652244717 1027 6620745 YIL048W NEO1 SGTC_2977 9011197 71.43 µM -1.52270197182092 0.14727059800335 no 2861 0.0639166422194142 1009 2704722 SGTC_2140 5586273 200 µM -1.5234326111502 0.147156173312735 no 2862 0.0638252541943254 1030 854421 SGTC_3343 9148379 18.9835 µM -1.52426052782902 0.147026586166241 no 2863 0.0637218216307418 976 1955036 SGTC_272 doxorubicin 8.13 µM -1.52786151831366 0.146463842498822 no 2864 0.0632734621679775 1036 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_731 3966-0296 387 µM -1.52826798965038 0.146400412254122 no 2865 0.0632230070623231 1025 660956 SGTC_588 3970-1144 52.9 µM -1.53383568819196 0.145533424033788 no 2866 0.0625350403899226 1020 1888707 SGTC_1659 st012954 42.1 µM -1.53484774304668 0.145376200968824 no 2867 0.062410616111293 1023 24207262 SGTC_1252 0493-0875 34.8 µM -1.535486880799 0.145276969585006 no 2868 0.0623321385957104 1021 3960963 SGTC_3231 9132313 49.47 µM -1.53612435932907 0.145178041213401 no 2869 0.0622539414899108 1029 4905967 SGTC_685 1278-0033 54.9 µM -1.53918344618197 0.144703941577456 no 2870 0.0618797588677485 1031 3590572 SGTC_1066 ketoconazole 628 nM -1.5396471071938 0.144632174145399 no 2871 0.0618231981060102 1027 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_249 wiskostatin 11.211 µM -1.54075202110218 0.144461247513309 no 2872 0.0616885752933306 1005 2775510 A n-wasp and actin depolymerizer. SGTC_471 1-acyl-paf 4 µM -1.54361968120721 0.144018264998756 no 2873 0.0613402471343116 1037 16759367 SGTC_697 0508-1955 564 µM -1.54428847024487 0.143915085523192 no 2874 0.0612592322358651 1029 6243113 SGTC_2789 5281112 71.43 µM -1.54572310912145 0.143693920460072 no 2875 0.0610857268600841 1014 765948 SGTC_1312 1218-2183 165 µM -1.54988295130592 0.143053933138856 no 2876 0.0605848061731462 1028 6744073 SGTC_2198 6589944 200 µM -1.5499653071124 0.143041282256534 no 2877 0.0605749215727746 1012 5290268 SGTC_734 2023-0417 80 µM -1.55192582033287 0.142740346070005 no 2878 0.0603399869707432 1028 3935732 SGTC_2017 5132927 60.65 µM -1.55193865562668 0.142738377280673 no 2879 0.0603384512292279 1031 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2545 solidagenone 89.61 µM -1.55585623317807 0.14213832286187 no 2880 0.0598711413887184 998 6708572 An anti ulcer agent SGTC_592 k241-0073 46.5 µM -1.55594700586582 0.142124439498358 no 2881 0.0598603472315255 1035 4230158 SGTC_1924 st058459 75.1 µM -1.55650429557604 0.142039224110861 no 2882 0.0597941110025985 1015 688683 SGTC_564 3555-0129 330 µM -1.55726264692322 0.141923319875338 no 2883 0.0597040699932173 1002 563260 SGTC_1406 3909-7906 11.9 µM -1.56165447836353 0.141253344476852 no 2884 0.059184704055543 988 X1406 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.56217297945506 0.141174388699493 no 2885 0.059123622107846 1016 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1568 digitonin 820 nM -1.56783997938337 0.140313385917529 no 2886 0.0584592410220335 1021 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2683 piperine 63.03 µM -1.5692313262722 0.140102541190819 no 2887 0.0582970236758367 1046 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2759 disulfiram 3.38 µM -1.57031376464537 0.139938657408457 no 2888 0.0581710667305859 1006 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_763 3453-1109 128 µM -1.57184376988266 0.139707233220638 no 2889 0.0579933939049121 1030 1560353 SGTC_1134 3477-0009 42.5 µM -1.57246418665847 0.139613464956471 no 2890 0.0579214692655055 1019 3973534 SGTC_1710 st031758 61.5 µM -1.57306642719083 0.139522484747866 no 2891 0.0578517188725372 1040 5394341 SGTC_2886 9058944 51.95 µM -1.57323852967524 0.139496492712039 no 2892 0.0578317984144668 1021 4949929 SGTC_2233 sulbentine 40.3845 µM -1.58275529454113 0.138064333867015 no 2893 0.056738624920415 1003 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1455 4262-0120 131 µM -1.58878745798632 0.137161775647891 no 2894 0.0560541928911255 1021 1529587 SGTC_1930 st074634 34.3 µM -1.59152135385449 0.136754048656908 no 2895 0.055746146819699 1025 684253 YOR116C RPO31 SGTC_2716 st080858 38.6235 µM -1.59295083598924 0.136541189166934 no 2896 0.0555856103374212 1022 5296050 SGTC_2144 5628481 200 µM -1.59310270122443 0.1365185887358 no 2897 0.0555685767377872 1021 2818399 SGTC_133 0724-0033 378.92 µM -1.59310364758548 0.136518447907326 no 2898 0.055568470604391 1038 280309 SGTC_2262 9014885 67.46 µM -1.59387492458247 0.136403706817343 no 2899 0.0554820258933094 1050 6457424 SGTC_2675 theaflavin digallate 100 µM -1.59623046540961 0.136053686964165 no 2900 0.0552186740607468 1046 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3333 9141820 12.094 µM -1.59882630089772 0.135668673373111 no 2901 0.0549296016712031 1011 1939433 SGTC_2602 kawain 100 µM -1.59932469190328 0.135594837647312 no 2902 0.0548742379137537 1015 5369129 SGTC_3175 9106517 49.47 µM -1.60059092072561 0.135407371979457 no 2903 0.0547337772592103 1047 41468073 SGTC_1824 st053723 68.6 µM -1.60071606058548 0.1353888546242 no 2904 0.0547199111502304 1027 675225 SGTC_1345 1488-0192 31.4 µM -1.60204162249405 0.13519281344327 no 2905 0.0545732028571068 1030 658348 SGTC_193 1273-0060 1.558 µM -1.60496717934407 0.13476083342439 no 2906 0.0542505138726687 1023 2847393 YHR072W ERG7 SGTC_134 0269-0018 6.916 µM -1.60537517138556 0.134700665729585 no 2907 0.0542056325426986 1042 4378915 SGTC_935 2996-0153 430 µM -1.60561105044075 0.134665888415702 no 2908 0.0541796979785657 1037 23738523 SGTC_909 3448-9333 149 µM -1.60630895816698 0.134563027044277 no 2909 0.0541030215280316 1038 3344074 SGTC_1378 2093-0007 380 nM -1.60719204205749 0.134432950730771 no 2910 0.0540061236000396 1037 3618014 SGTC_2219 9098279 200 µM -1.60929258799176 0.134123891924825 no 2911 0.0537761895232555 1040 902349 SGTC_2167 5876490 200 µM -1.60995454781423 0.134026597275827 no 2912 0.0537038896523492 1025 686534 SGTC_1934 st074720 32.6 µM -1.61159388031986 0.133785857485612 no 2913 0.0535251716263222 1017 17250992 SGTC_3112 9123419 49.47 µM -1.61192227910914 0.13373766711913 no 2914 0.053489426708112 1047 17015854 SGTC_311 1315-0136 58 µM -1.61324768675527 0.133543293527914 no 2915 0.0533453534699099 1040 6759207 SGTC_2795 7780010 54.55 µM -1.61576371355112 0.133174847998984 no 2916 0.0530727048579058 1014 953673 SGTC_15 0266-0086 27.098 µM -1.61715562107584 0.132971318683071 no 2917 0.0529223465636432 1057 1712902 YIL048W NEO1 SGTC_128 0906-2981 13.371 µM -1.62281951113122 0.132145335095947 no 2918 0.0523139967883353 1037 6740226 SGTC_1335 1486-0900 202 µM -1.62297979412216 0.132122012089282 no 2919 0.0522968621718413 1028 X1335 SGTC_1496 4469-0713 57.4 µM -1.62537094753878 0.131774408936872 no 2920 0.0520417712165415 1050 746691 SGTC_1159 4092-0538 61.2 µM -1.62815518035307 0.131370459356147 no 2921 0.0517459927917142 1038 717301 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.63059587347436 0.131017056067544 no 2922 0.0514878102352899 1008 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3339 9145883 14.936 µM -1.63677519491026 0.130125251848445 no 2923 0.0508387252513265 1000 2030670 SGTC_2396 5342950 42.78 µM -1.63767657962718 0.129995515269004 no 2924 0.0507445893613866 1000 1886677 SGTC_722 3534-0461 190 µM -1.63988915275426 0.129677438654517 no 2925 0.0505141083226774 1030 658262 SGTC_1600 coumarin 106 71.1 µM -1.63994855592025 0.129668906370001 no 2926 0.0505079318825949 1034 100336 A hepatotoxic, DNA x-linker. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.64303796883391 0.129225699069008 no 2927 0.0501875388619436 1039 688751 SGTC_3014 9081533 49.47 µM -1.64413221058082 0.129068971227462 no 2928 0.0500744478950151 1043 21367265 SGTC_2431 5490079 200 µM -1.64436523276103 0.129035612575717 no 2929 0.0500503910833833 1048 5722345 SGTC_810 3825-7150 143 µM -1.64700664172084 0.12865789553215 no 2930 0.0497783403382016 1006 22330411 YGL099W LSG1 SGTC_3289 9119912 71.43 µM -1.64707052861249 0.128648769326502 no 2931 0.0497717749763896 1039 17014829 SGTC_2625 euphol 100 µM -1.65048692336641 0.128161393490737 no 2932 0.0494216928522351 1024 6708538 A triterpene alcohol. SGTC_2447 5741742 33.78 µM -1.65445036008092 0.127597586387975 no 2933 0.0490180206860497 1036 1776504 SGTC_2639 lactacystin 53 µM -1.6572355289197 0.127202423436064 no 2934 0.0487359330253405 1010 3870 A proteasome inhibitor. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.65868885332459 0.12699656250914 no 2935 0.0485892533380413 1010 6708739 YPR165W RHO1 SGTC_605 1315-0399 119 µM -1.6621345345665 0.126509414566213 no 2936 0.0482429012853195 1046 24020461 SGTC_1510 1123-0200 71.5 µM -1.66510423852668 0.12609060562454 no 2937 0.0479459806343041 1044 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1393 3470-5649 58.2 µM -1.66552385059021 0.126031506949266 no 2938 0.0479041446569125 1031 4108395 SGTC_2435 5706476 10.6 µM -1.67074759085302 0.125297405461407 no 2939 0.0473857721796033 1028 5725375 SGTC_1556 plumbagin 1.48 µM -1.67137934562249 0.125208826606419 no 2940 0.047323386470085 991 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_966 1300-0360 30.2 µM -1.67469935053345 0.124744044705309 no 2941 0.0469966174685142 990 70588 SGTC_3216 9129716 49.47 µM -1.67585870028477 0.124582026690779 no 2942 0.0468829364743317 1022 8056934 SGTC_554 4483-2211 187 µM -1.67691779630619 0.124434147660573 no 2943 0.0467792788095153 1053 747107 SGTC_1333 1482-0047 286 µM -1.67755892936579 0.124344687456583 no 2944 0.0467166181223765 1042 3811116 SGTC_1044 1222-0021 1.78 µM -1.67887726076309 0.124160876056959 no 2945 0.0465879835343281 987 4306703 SGTC_476 mead acid 10 µM -1.67960082490806 0.124060072290115 no 2946 0.0465175035452697 1066 5312531 An omega 9 fatty acid. SGTC_1795 st049545 62.3 µM -1.68169960854863 0.123768003009272 no 2947 0.0463135519957451 1020 5291882 SGTC_1977 st070720 65.3 µM -1.68762891464368 0.122945475743122 no 2948 0.0457412425745175 1033 682188 SGTC_147 4466-0538 29.23 µM -1.68917752387245 0.122731281685185 no 2949 0.0455927074481165 1040 6742687 YHR072W ERG7 SGTC_2835 9006588 71.43 µM -1.68977068842217 0.122649308197648 no 2950 0.0455359167831136 1007 2345538 SGTC_2380 9035439 200 µM -1.69024277617256 0.122584094599327 no 2951 0.0454907588944165 1040 6462575 SGTC_2286 7945697 125 µM -1.69074882504074 0.122514216674848 no 2952 0.045442392429365 1031 1245733 SGTC_1236 0330-0013 258 µM -1.69918155967251 0.121353891671029 no 2953 0.0446424898809973 1052 4617066 SGTC_415 dibenzyl ketone 100 µM -1.70066356178346 0.121150772534215 no 2954 0.044503090575846 1041 7593 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.70188089047592 0.12098410778968 no 2955 0.0443888493612187 1031 6708630 An antioxidant. SGTC_1854 st056233 32.9 µM -1.70824405815866 0.120115550691906 no 2956 0.0437955332907672 1049 5393174 SGTC_3157 9099274 49.47 µM -1.71538591993958 0.119145948199938 no 2957 0.043137247568271 1028 17217662 SGTC_696 1560-0013 611 µM -1.71680355454299 0.118954144560628 no 2958 0.0430075356412684 1038 1650269 SGTC_1884 5633444 25 µM -1.71695822994233 0.118933230433085 no 2959 0.0429934021083817 1035 5724239 SGTC_1540 guanosine 70.6 µM -1.71818857956847 0.118766963622784 no 2960 0.0428811119696226 1041 6802 Guanosine is a purine nucleoside SGTC_2852 9023854 51.95 µM -1.72312654089649 0.118101310257568 no 2961 0.0424328220893457 1047 19798528 SGTC_1494 4358-1428 177 µM -1.72822375098759 0.117416961775225 no 2962 0.0419740585642348 1038 1564571 SGTC_939 1165-0479 45.3 µM -1.7297382777796 0.117214164484555 no 2963 0.0418385232397676 1029 1377347 SGTC_337 1315-0038 354 µM -1.73116852799643 0.117022879854616 no 2964 0.0417108554073396 1049 1626437 SGTC_1820 st053765 18.6 µM -1.73374553446346 0.116678784222109 no 2965 0.0414816216956381 1036 3690829 SGTC_1611 st001856 99.4 µM -1.73382447460518 0.11666825505037 no 2966 0.0414746158414516 1050 647478 SGTC_2894 9048625 32.47 µM -1.73726497456498 0.116210009659049 no 2967 0.0411702054415565 1044 4092861 SGTC_85 0868-0259 160.055 µM -1.73847210187444 0.116049533636866 no 2968 0.0410638308494008 1025 83173 SGTC_3264 9137442 49.47 µM -1.74956955097871 0.114581601465716 no 2969 0.0400963088413902 1023 17015726 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.75136825500721 0.114344925212571 no 2970 0.0399412487457962 1068 442882 SGTC_2188 6126565 140.678 µM -1.75163961357948 0.114309249671917 no 2971 0.0399178982189141 1038 874518 SGTC_2902 5787006 60.46 µM -1.75523957093665 0.11383671277045 no 2972 0.0396091689735099 1029 591003 SGTC_3293 9120939 62.045 µM -1.75694479846911 0.113613368058657 no 2973 0.0394636093669761 1047 934087 SGTC_452 diindolylmethane 8 µM -1.75939237187337 0.113293339774757 no 2974 0.0392554433401273 1048 3071 Inhibits expression of several cancer promoting factors. SGTC_2263 7948595 193.29 µM -1.76742654205746 0.112247366783901 no 2975 0.0385784105665293 1044 2971371 SGTC_1579 chlormadinone acetate 49.4 µM -1.76893833706077 0.112051319363171 no 2976 0.0384520827726872 1044 45114258 A steroidal progestin. SGTC_1853 st056710 91.2 µM -1.76923222145916 0.112013237289071 no 2977 0.0384275645506165 1050 269167 SGTC_3249 9135183 49.47 µM -1.77298767851271 0.111527412819477 no 2978 0.0381153743028481 1009 4902779 SGTC_1291 0993-0025 5.79 µM -1.77463655751591 0.111314582713035 no 2979 0.0379789584531285 1048 4353356 SGTC_1413 3910-0535 34.4 µM -1.77633816028253 0.111095252250515 no 2980 0.0378385985394895 1048 2876951 SGTC_513 4245-1575 41.7 µM -1.78605611900637 0.109848572156716 no 2981 0.0370450860667579 1023 719745 SGTC_1718 roemerine 11.9335 µM -1.78796626937306 0.109604711577142 no 2982 0.0368907249856998 987 235224 An aporphine alkaloid with mutagenic activity. SGTC_426 0988-0037 14.6 µM -1.78811972531228 0.109585137407125 no 2983 0.0368783469192247 1053 5383008 SGTC_1874 staurosporine 7.6 µM -1.78881276459157 0.10949676760657 no 2984 0.0368224872614631 1040 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_293 4049-0273 38.5 µM -1.79317183995168 0.108942112750768 no 2985 0.0364727256746839 1043 1380311 SGTC_3188 9110789 49.47 µM -1.79792796913534 0.108339243436869 no 2986 0.0360942116018136 1042 849217 SGTC_2022 5136654 200 µM -1.80402616322073 0.107569776491557 no 2987 0.0356136027692097 1047 1713771 SGTC_1716 st033144 30.6155 µM -1.80509601619917 0.107435190060457 no 2988 0.0355298291856466 1049 674617 SGTC_1411 3909-8223 150 µM -1.80921145811131 0.106918603063649 no 2989 0.0352090791069586 1063 X1411 SGTC_182 3448-4371 550.524 µM -1.80975224950729 0.106850854164589 no 2990 0.0351671079425967 1046 3491403 SGTC_3042 9091578 49.47 µM -1.81025498655736 0.106787900398308 no 2991 0.0351281270258474 1037 25236497 SGTC_1844 rapamycin 4 nM -1.8109990421573 0.106694777352745 no 2992 0.0350704999692541 994 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2778 tioconazole 65.09 nM -1.81159499379489 0.106620232692137 no 2993 0.0350243995255085 1021 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2193 5925765 200 µM -1.81262289693238 0.106491745695143 no 2994 0.0349450019073545 1044 877370 SGTC_985 1493-0307 8.71 µM -1.81390548053268 0.106331580676421 no 2995 0.034846139419313 1056 3278274 SGTC_23 0213-0011 39.996 µM -1.82041703749793 0.105521121122328 no 2996 0.0343477598944166 1049 627608 SGTC_1171 0368-0077 21.4 µM -1.82142142790451 0.105396508641399 no 2997 0.0342714101858977 1057 3239779 SGTC_2084 5306078 60.6385 µM -1.82384304588534 0.10509650169162 no 2998 0.0340879020357396 1066 679340 SGTC_2020 4017018 200 µM -1.82645976338715 0.104773019723748 no 2999 0.0338905183937337 1057 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2142 5622915 118.518 µM -1.82745261192142 0.104650471393628 no 3000 0.0338158725216174 1042 5322196 SGTC_1001 4048-4355 44.4 µM -1.82789597685804 0.104595779942894 no 3001 0.0337825824887662 1047 21824233 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.82975031315729 0.104367261965654 no 3002 0.0336436418370738 1040 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2225 6654152 15.4 µM -1.83092936567807 0.104222150447366 no 3003 0.0335555432860835 1040 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1996 st072960 66.8 µM -1.83127176573341 0.104180037083336 no 3004 0.0335299948362404 1054 1719405 SGTC_102 gallobenzophenone 83.616 µM -1.83680373760459 0.103501343217402 no 3005 0.0331194369834269 1030 70837 SGTC_1091 telmisartan 47.6 µM -1.83756546363688 0.103408142250033 no 3006 0.0330632309083115 1057 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1367 1812-0510 76.9 µM -1.84178059871979 0.102893500679251 no 3007 0.0327536245374507 1046 1142582 YDR527W RBA50 SGTC_353 1988-1175 58.3 µM -1.84267215453646 0.102784886139023 no 3008 0.0326884459774911 1026 2788357 SGTC_2663 amphotericin b 100 µM -1.84475585048427 0.10253136308368 no 3009 0.0325365311933196 1053 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2032 5185112 25.99 µM -1.84536602573175 0.102457209255782 no 3010 0.0324921559035282 1042 5718189 SGTC_2221 6807166 181.081 µM -1.84833263284977 0.102097236875753 no 3011 0.0322771188570315 1061 674925 SGTC_1430 4049-0248 69.1 µM -1.8484460424532 0.102083493875058 no 3012 0.0322689216296705 1054 22774488 SGTC_2799 7812892 81.82 µM -1.85355027845095 0.101466354213894 no 3013 0.0319017633380778 1033 20205235 SGTC_2475 5812728 15.03 µM -1.8678010185977 0.0997577285839693 no 3014 0.0308949057201706 1056 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_374 0880-0231 82.3 µM -1.86894358165864 0.0996216540305729 no 3015 0.0308153320395149 1032 6833587 SGTC_1248 0469-0687 58.6 µM -1.87518837319615 0.0988803210450042 no 3016 0.0303834065627308 1052 4017482 SGTC_1708 st033234 31.827 µM -1.88494735564166 0.0977299060922882 no 3017 0.0297184728512097 1060 674664 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.88728054544344 0.0974563227021892 no 3018 0.029561300850182 1020 688669 SGTC_2791 5663188 71.43 µM -1.89181113617479 0.0969266834021762 no 3019 0.0292580745060034 1049 54690634 SGTC_3247 9135149 49.47 µM -1.89491070120453 0.0965655545776442 no 3020 0.0290521166047744 1049 8934436 YOR116C RPO31 SGTC_62 0180-0423 3.232 µM -1.89555005160984 0.0964911872997768 no 3021 0.0290097836823891 1050 30102 YGL099W LSG1 SGTC_2667 digitoxin 100 µM -1.89576871156112 0.096465763103964 no 3022 0.0289953174516948 1050 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_609 0986-0026 86.3 µM -1.8966763331044 0.0963602840601732 no 3023 0.0289353345759071 1042 2848610 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.89677222141699 0.0963491453726118 no 3024 0.0289290035386939 1033 279621 SGTC_716 1683-5115 658 µM -1.90308722693952 0.0956176561919971 no 3025 0.028514582178661 1047 723597 SGTC_1968 st069590 43.6 µM -1.90903414500144 0.0949325477203427 no 3026 0.0281288435280982 1046 6384066 SGTC_1974 st069448 26.9 µM -1.91761665096326 0.0939501948363077 no 3027 0.0275798186181126 1054 6323587 YNR016C ACC1 SGTC_2251 lansoprazole 556 µM -1.91900355195579 0.0937921569101299 no 3028 0.0274919421642903 1069 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1405 3909-7894 12 µM -1.93397165141651 0.0920990076794481 no 3029 0.0265583067153831 1024 7104060 SGTC_1888 azatryptophan 97.5 µM -1.93678395609342 0.0917834289224991 no 3030 0.0263858789588784 1065 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2101 5377231 179.231 µM -1.93785055561787 0.0916639517208865 no 3031 0.0263207288890948 1073 2844213 SGTC_1855 st056195 39.6 µM -1.94149695591482 0.091256363542451 no 3032 0.026099014149755 1022 4028379 SGTC_393 acivicin 6.25 µM -1.94367807258467 0.0910132053308212 no 3033 0.0259671422295792 1007 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_151 3013-0144 2.285 µM -1.94409023529038 0.0909673100877117 no 3034 0.0259422852924761 1044 906558 YHR107C CDC12 SGTC_869 0564-0080 44.1 µM -1.94911589478271 0.0904090719102912 no 3035 0.0256407929486193 1065 6843321 SGTC_2350 9023895 38.85 µM -1.95019188793886 0.0902898844859946 no 3036 0.0255766261556046 1043 2997209 SGTC_57 miconazole 162.5 nM -1.95053063535641 0.0902523857040781 no 3037 0.0255564528201897 1035 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3303 9125618 40.5795 µM -1.95286007312465 0.0899948339958838 no 3038 0.0254180889521121 1045 22695467 SGTC_2865 9030313 51.95 µM -1.9640074665017 0.0887698915140977 no 3039 0.0247646130193881 1065 42562754 SGTC_648 0375-0473 33.3 µM -1.96666381593809 0.0884798362454117 no 3040 0.0246109905209904 1070 1713139 SGTC_3183 9108214 49.47 µM -1.9708262173518 0.0880267513569053 no 3041 0.0243718784107923 1077 4974831 SGTC_2138 5575593 77.673 µM -1.97324321725809 0.0877644517206077 no 3042 0.0242339294111836 1054 762213 SGTC_2515 chrysin 20.77 µM -1.97578060022692 0.0874897155629553 no 3043 0.0240898157780807 1049 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.97658160799085 0.0874031195587206 no 3044 0.0240444713952556 1059 115019 SGTC_1416 3966-0321 25.3 µM -1.97957162029599 0.0870804379627767 no 3045 0.0238758422683782 1071 582530 YLR208W SEC13 SGTC_2295 7971645 200 µM -1.9834109976547 0.0866673988404318 no 3046 0.023660769840204 1070 2978226 YKL099C UTP11 SGTC_943 3253-1379 105 µM -1.98697256108806 0.086285557616158 no 3047 0.0234627188121631 1047 668464 SGTC_3118 9124250 49.47 µM -1.99031391504349 0.0859284706284227 no 3048 0.023278183053821 1051 1504786 SGTC_2619 obliquin 87.91 µM -1.99054684910533 0.0859036185058348 no 3049 0.0232653642859407 1049 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1920 st075728 45.7 µM -1.99121936304078 0.0858318970597557 no 3050 0.0232283880074659 1049 3400306 SGTC_2128 5255449 168.493 µM -1.99312952587983 0.0856284287893688 no 3051 0.0231236328092011 1049 736008 SGTC_1143 3454-2408 5.08 µM -2.00418932600786 0.0844574457352941 no 3052 0.0225248917704215 1020 X1143 SGTC_2747 doxorubicin 7.63 µM -2.0048675312564 0.0843860320121845 no 3053 0.0224886053208106 1051 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1522 st012842 45.6 µM -2.00829931498977 0.0840253662797133 no 3054 0.022305747323841 1007 3491067 YOR116C RPO31 SGTC_2877 9040724 71.43 µM -2.00932956859212 0.0839173172558317 no 3055 0.0222510970548294 1071 6463895 SGTC_2867 9039098 71.43 µM -2.01005722285474 0.0838410665780371 no 3056 0.0222125664142936 1043 6463460 SGTC_3107 9121808 49.47 µM -2.01134663388103 0.0837060773952481 no 3057 0.0221444279837229 1042 662681 SGTC_674 0498-0004 451 µM -2.01437940222072 0.0833892188723952 no 3058 0.0219848576168722 1023 4231473 SGTC_3078 9116413 49.47 µM -2.01519962533945 0.0833036784275445 no 3059 0.0219418683894434 1052 17177322 SGTC_3319 9138450 16.7555 µM -2.01727975110939 0.0830870394888443 no 3060 0.0218331637563016 1051 2029690 SGTC_975 1335-0046 28.5 µM -2.01964882953073 0.0828408233670133 no 3061 0.0217099131851726 1057 16486740 SGTC_3024 9090631 49.47 µM -2.02417676220464 0.0823717673780848 no 3062 0.0214759838276761 1054 25236383 SGTC_1959 st077091 55.8 µM -2.02720682587715 0.0820589968345528 no 3063 0.021320632692332 1058 821356 YKL052C ASK1 SGTC_2237 6667747 47.222 µM -2.02952790609003 0.0818200151210707 no 3064 0.0212022747969973 1077 729940 YDL015C TSC13 SGTC_740 k014-0057 261 µM -2.03000677119643 0.0817707758319249 no 3065 0.0211779255064168 1067 4012779 SGTC_577 r071-0003 38.6 µM -2.03064574095646 0.0817051085772796 no 3066 0.0211454720713032 1078 4568517 YMR134W ERG29 SGTC_3290 9121031 71.43 µM -2.03290957740126 0.0814727728462336 no 3067 0.0210308296273703 1055 17014854 SGTC_2329 6138490 200 µM -2.0345369009348 0.0813060699819745 no 3068 0.0209487459940259 1069 720019 SGTC_2861 9024595 19.48 µM -2.03653036942638 0.0811022100907451 no 3069 0.0208485633702282 1074 16482810 SGTC_2751 anetholtrithion 17.25 µM -2.03727422285145 0.0810262396286895 no 3070 0.0208112847468158 1070 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -2.03906001343982 0.0808440743941231 no 3071 0.0207220191831767 1065 688662 SGTC_2647 atorvastatin 60.16 µM -2.04117015188228 0.08062922177027 no 3072 0.0206169587104547 1058 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_352 k048-0007 5.11 µM -2.04240995409924 0.0805031873770377 no 3073 0.020555441590893 1054 6811911 SGTC_505 gw-5074 63.9 µM -2.04537746330073 0.0802021242217713 no 3074 0.020408829521663 1058 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3287 9117173 37.0625 µM -2.04650054739972 0.0800884060478331 no 3075 0.0203535743319664 1033 2789709 SGTC_1555 citronellol 128 µM -2.05473218594088 0.0792586273436992 no 3076 0.0199524396879693 1073 8842 A terpine precursor. SGTC_1138 3761-0006 1.03 µM -2.05663378369322 0.0790678681922355 no 3077 0.0198607329899019 1071 12061087 SGTC_1112 tnp00069 1.16933 µM -2.06077549669615 0.0786535950629664 no 3078 0.0196622315937529 1066 145826 SGTC_2441 5730946 39.09 µM -2.06331026634921 0.0784008684697021 no 3079 0.0195415796430731 1065 1774275 SGTC_844 0330-0132 15.3 µM -2.07361523832549 0.0773797584705445 no 3080 0.0190575294199328 1073 2828079 SGTC_198 3454-2873 16.191 µM -2.07502394079116 0.0772409598955151 no 3081 0.0189921579984445 1069 710957 SGTC_475 α-linolenic acid 10 µM -2.07667207953911 0.0770788100121288 no 3082 0.0189159176172458 1055 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1389 3405-0187 19 µM -2.08133337638856 0.0766216150789376 no 3083 0.0187017010959379 1056 799890 SGTC_2780 5215298 71.43 µM -2.08251793997523 0.0765057586127036 no 3084 0.0186475929826426 1071 2834131 SGTC_610 4215-0184 155 µM -2.09009685300649 0.0757676532464898 no 3085 0.0183045501611829 1035 5605015 SGTC_2640 pentamidine 10.38 µM -2.09294425883035 0.0754917523029131 no 3086 0.0181770653651932 1008 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1505 k297-0037 20.6 µM -2.09352145878513 0.075435917642863 no 3087 0.0181513152690275 1075 4089396 SGTC_1000 4048-0884 8.67 µM -2.10355113080704 0.0744707286043944 no 3088 0.0177088103308476 1072 13040088 SGTC_846 0335-0850 148 µM -2.10356495359115 0.0744694049278252 no 3089 0.0177082068847134 1064 6819598 SGTC_55 0767-0285 6.563 µM -2.10379712778795 0.0744471744975386 no 3090 0.0176980737324362 1059 3116166 SGTC_2846 9008642 19.48 µM -2.10489916557321 0.0743417246528931 no 3091 0.0176500431781477 1076 2992898 SGTC_1450 4112-4260 37.6 µM -2.10698339928862 0.0741426040518343 no 3092 0.0175595092850369 1064 1633175 SGTC_1237 0330-0133 46.1 µM -2.10747876077829 0.0740953388717956 no 3093 0.0175380504195836 1064 X1237 YHR072W ERG7 SGTC_384 k007-0144 5.16 µM -2.10915848774647 0.0739352381758044 no 3094 0.0174654518875761 1069 6824886 SGTC_2671 danthron 100 µM -2.10984176352755 0.0738701884379608 no 3095 0.0174359939117048 1073 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1209 2323-2347 50.3 µM -2.11035986001073 0.0738208933867847 no 3096 0.0174136855789819 1055 5412760 SGTC_2539 epi(13)torulosol 80 µM -2.11122143189281 0.0737389735370308 no 3097 0.0173766417607337 1034 6708597 SGTC_2740 felodipine 17.08 µM -2.11283986869891 0.0735852774587617 no 3098 0.0173072379942272 1080 3333 L-type calcium channel blocker SGTC_1900 st060200 72.8 µM -2.11361868548991 0.0735114038811838 no 3099 0.0172739243050486 1056 688945 SGTC_901 1112-0062 60.1 µM -2.11410107311454 0.073465676127292 no 3100 0.0172533177816173 1070 1908457 SGTC_1186 1319-0216 26 µM -2.11412705600606 0.0734632137063807 no 3101 0.0172522084467345 1076 4565136 SGTC_1754 st042065 16.137 µM -2.11591240336003 0.0732941659354483 no 3102 0.0171761291654803 1029 1126236 YIL048W NEO1 SGTC_1950 st077106 7.18 µM -2.11935630026361 0.0729689172523517 no 3103 0.0170301834859084 1049 13831864 SGTC_1764 st044502 93.5 µM -2.11989525988989 0.0729181169269684 no 3104 0.0170074396206848 1063 8407 SGTC_1644 st010134 20.9 µM -2.12877133719874 0.0720853802462254 no 3105 0.0166365917188719 1076 3818134 SGTC_81 0411-0046 9.971 µM -2.13279415459302 0.0717103764554906 no 3106 0.0164708079935596 1059 12925265 SGTC_2094 5332512 191.667 µM -2.14095956900162 0.070953806855937 no 3107 0.0161386493252989 1078 755774 SGTC_3240 9133527 49.47 µM -2.14700013040447 0.070398073022481 no 3108 0.0158966356168401 1074 17617455 SGTC_2486 5283202 22.39 µM -2.14773122160628 0.0703310400291553 no 3109 0.0158675567964069 1061 1377751 SGTC_3090 9117696 49.47 µM -2.14966325081738 0.0701541305136334 no 3110 0.0157909306575285 1068 7923821 SGTC_2083 5306046 65.942 µM -2.15129360996585 0.070005110386432 no 3111 0.0157265161593705 1066 539837 SGTC_266 formosanin C 406 nM -2.15575901733237 0.0695982046328977 no 3112 0.0155512435688875 1052 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2738 aclarubicin 5.55 µM -2.15607635331636 0.0695693571599267 no 3113 0.0155388518050141 1089 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_122 0236-0016 402.397 µM -2.16007877773156 0.0692063060744058 no 3114 0.0153832858050199 1056 6808838 SGTC_670 4204-0025 119 µM -2.17176751664285 0.0681544010002279 no 3115 0.0149366014915913 1069 719039 SGTC_3223 9129970 49.47 µM -2.17304936846541 0.0680397982629943 no 3116 0.0148883009125715 1076 17248386 SGTC_2325 6158266 200 µM -2.17961895355699 0.06745478457169 no 3117 0.0146428593331161 1064 3623240 SGTC_2327 6189656 200 µM -2.18250381543601 0.0671991226595279 no 3118 0.0145361849879594 1067 5349088 SGTC_1982 st072467 71.9 µM -2.18465855102381 0.0670086551892351 no 3119 0.0144569457106283 1072 3163533 SGTC_3044 9093193 49.47 µM -2.18513549019249 0.0669665527301071 no 3120 0.0144394568706669 1067 25236277 SGTC_1792 st045773 43.6 µM -2.1899444503703 0.0665431777091049 no 3121 0.0142641328665883 1070 2919270 SGTC_1329 1447-1697 50.6 µM -2.19255677441285 0.0663140619425673 no 3122 0.0141696641756799 1077 2840515 SGTC_2220 6782180 200 µM -2.1945103773003 0.0661431194062671 no 3123 0.0140993693719739 1070 833803 SGTC_346 4513-0042 7.16 µM -2.20223189740717 0.0654708163926678 no 3124 0.0138244659925605 1061 2827372 SGTC_3248 9135562 49.47 µM -2.20256662465599 0.0654417924095897 no 3125 0.0138126542254203 1073 17650701 SGTC_1619 st003326 88.7 µM -2.2049802327587 0.0652328053319151 no 3126 0.013727740836314 1037 2849032 SGTC_1407 3909-7909 12.3 µM -2.21067750043315 0.0647415499410322 no 3127 0.0135290888386684 1051 4411780 SGTC_953 1188-0045 9.7 µM -2.22486454000423 0.0635307357677558 no 3128 0.0130451665662543 1059 6144426 SGTC_576 1073-0113 22.7 µM -2.22968679465394 0.063123210436148 no 3129 0.0128841215833888 1069 5439563 SGTC_1072 oxiconazole 14.9 nM -2.23172267573334 0.0629517719465519 no 3130 0.0128166487996515 1054 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_822 1487-0950 154 µM -2.23278712039897 0.06286228117348 no 3131 0.0127814930144337 1060 1958375 SGTC_1188 1403-0014 4.57 µM -2.23408169377861 0.0627535764663972 no 3132 0.0127388491415507 1067 9614867 SGTC_2397 5161689 200 µM -2.23520792734022 0.0626591263764788 no 3133 0.0127018506487643 1068 2259942 SGTC_2985 9022375 71.43 µM -2.24080253833717 0.0621915830534319 no 3134 0.0125194342325051 1065 4939335 SGTC_809 3998-0021 90 µM -2.24341253148665 0.0619743981582996 no 3135 0.0124351122676948 1068 715485 SGTC_3314 9135860 59.4275 µM -2.24691812464239 0.0616836197604087 no 3136 0.0123226300800397 1063 25252478 SGTC_2096 5468907 200 µM -2.24845684615737 0.0615563243129375 no 3137 0.0122735369299315 1086 759785 SGTC_2201 6605497 169.863 µM -2.24947975704273 0.0614718144638059 no 3138 0.0122409946526315 1084 670741 SGTC_1181 1222-0449 220 µM -2.26365457396458 0.0603100398183634 no 3139 0.0117976842306409 1078 658318 SGTC_601 0986-0029 62.9 µM -2.26682004980004 0.0600529583430545 no 3140 0.0117006104010966 1059 24747981 SGTC_2532 xanthone 78.9 µM -2.26793055657068 0.0599629730594914 no 3141 0.0116667197893272 1082 7020 An insecticide. SGTC_1483 3453-0561 55.9 µM -2.26865891546547 0.0599040109014187 no 3142 0.0116445379264428 1081 4546991 SGTC_2159 5658611 73.75 µM -2.27268539689405 0.0595788779328102 no 3143 0.0115225726441661 1073 793844 SGTC_2306 7482397 179.52 µM -2.27737251676281 0.0592021430651572 no 3144 0.0113819949268065 1082 891448 SGTC_2196 6573537 42.6665 µM -2.2815509216201 0.0588678743619807 no 3145 0.011257933540478 1090 2903087 SGTC_1460 k062-0059 9.15 µM -2.28536029343326 0.0585644202251607 no 3146 0.0111458551170817 1064 1373085 SGTC_2518 prenyletin 46.28 µM -2.28691820271325 0.058440671743401 no 3147 0.011100298970335 1081 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2676 harmalol 100 µM -2.28841460468459 0.0583220023677144 no 3148 0.0110566939672106 1074 5459187 A monoamine oxidase inhibitor SGTC_3329 9141233 27.5565 µM -2.29146504751622 0.0580806789193848 no 3149 0.0109682655872519 1060 4909101 YNL103W MET4 SGTC_2384 9036245 200 µM -2.29851156219906 0.0575262223073536 no 3150 0.0107663452928688 1071 6462766 SGTC_2879 9041815 71.43 µM -2.30171323383255 0.0572756775962021 no 3151 0.0106756746968229 1087 4942971 SGTC_269 exalamide 29 µM -2.30244440230086 0.0572185811079119 no 3152 0.010655061695348 1086 3316 A derivative of salicylamide. SGTC_551 k048-0028 34.9 µM -2.3059757259543 0.0569434526329952 no 3153 0.010555994362533 1064 6836383 SGTC_1967 st070177 51.4 µM -2.31083545948291 0.0565665310287497 no 3154 0.0104209725388767 1082 5729214 SGTC_2443 5493264 126.67 µM -2.31397958970137 0.056323721084504 no 3155 0.0103344208713307 1082 5340055 SGTC_995 3931-2021 34.6 µM -2.31681818325309 0.0561052130509331 no 3156 0.0102568190490876 1085 730143 SGTC_2669 eugenol 100 µM -2.31930018668791 0.0559147027561467 no 3157 0.0101893826615621 1084 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1067 clotrimazole 1.36 µM -2.32717598654447 0.0553135599472673 no 3158 0.00997795027628476 1074 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2803 7707263 71.43 µM -2.3309989471989 0.0550236074650336 no 3159 0.00987670759812582 1066 2199229 SGTC_3202 9113761 49.47 µM -2.33294285533276 0.0548766330242454 no 3160 0.00982557236511362 1073 4798415 SGTC_2462 5162487 171.77 µM -2.33334552742413 0.0548462267385181 no 3161 0.00981500888109789 1080 2259986 SGTC_1733 st037357 54.9 µM -2.33878903259471 0.0544364861596422 no 3162 0.00967317730544066 1066 1272339 YGL099W LSG1 SGTC_3162 9099653 49.47 µM -2.34474618633778 0.0539908612538648 no 3163 0.00952001802713003 1081 25237511 SGTC_829 1635-0120 117 µM -2.35621189032956 0.0531413010288114 no 3164 0.00923119157577007 1060 285054 SGTC_93 0109-0045 59.227 µM -2.36320877057843 0.0526280915175783 no 3165 0.00905873007745512 1087 88733 SGTC_2027 5150920 200 µM -2.37395491420615 0.0518475479427839 no 3166 0.00879934962456275 1072 786715 SGTC_2969 9091408 28.7 µM -2.38024512806743 0.0513949459278152 no 3167 0.00865056240511454 1073 4286311 SGTC_1421 4029-0249 71.4 µM -2.39104436058104 0.0506252392693788 no 3168 0.00840026140677596 1080 2894095 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.39494878678629 0.0503492248598702 no 3169 0.00831134343483636 1073 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1794 st048918 76.9 µM -2.39800620129282 0.0501339263043498 no 3170 0.00824229307923497 1060 672303 SGTC_2420 aureobasidin a 50 nM -2.4059971889794 0.049574677925375 no 3171 0.00806419440759016 1076 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_155 k072-0202 43.6 µM -2.42098074916411 0.0485394827839397 no 3172 0.00773934848359918 1079 5857737 SGTC_9 0092-0002 10.449 µM -2.42952015540163 0.0479572828483288 no 3173 0.00755941213334822 1085 759368 SGTC_978 1416-0512 87.4 µM -2.43525314466855 0.0475695645441647 no 3174 0.00744068734011526 1089 6814003 SGTC_398 bronopol 33.3 µM -2.45417378304173 0.0463077632941121 no 3175 0.00706043605171678 1079 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2764 methyldopa 94.69 µM -2.45424357695868 0.0463031590392953 no 3176 0.00705906574005876 1078 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1403 3909-7815 62.9 µM -2.46086332419001 0.0458681271228943 no 3177 0.0069301577811593 1087 6615483 SGTC_2953 9074162 66.49 µM -2.46829394312858 0.0453837258916462 no 3178 0.00678793941640543 1071 16451992 SGTC_2490 carminic acid 95.39 µM -2.47698045726755 0.0448226786157152 no 3179 0.00662495783679239 1077 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2365 9042475 200 µM -2.47986848696621 0.0446373874386825 no 3180 0.00657154243617654 1069 6464479 SGTC_2844 9010103 25.97 µM -2.48956583833403 0.0440197310965672 no 3181 0.00639496136066946 1074 2480525 SGTC_423 5-fluorouracil 457 µM -2.49298541243248 0.0438035778057784 no 3182 0.00633370252024963 1065 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1679 SEC14.276 6.7 µM -2.49451300109516 0.0437072951084512 no 3183 0.00630650528957267 1068 1005053 YMR079W SEC14 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -2.49533774817355 0.0436553829840364 no 3184 0.00629186449077017 1081 803109 SGTC_109 0132-0036 33.701 µM -2.51695888038113 0.0423121409582188 no 3185 0.00591863216123096 1072 67274 A color developer. SGTC_439 amiodarone 34.4 µM -2.5270285841517 0.0416980618297365 no 3186 0.00575160699622864 1076 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1321 1326-2144 215 µM -2.52805996331854 0.0416355750353708 no 3187 0.00573473805961713 1086 3513030 SGTC_2967 9089538 49.85 µM -2.53254992133594 0.0413644312804829 no 3188 0.00566181221595111 1082 728216 SGTC_2063 5246145 200 µM -2.53438285022794 0.0412541548293094 no 3189 0.00563227926222912 1087 711240 SGTC_1076 itraconazole 331 nM -2.53812095115334 0.0410299941448571 no 3190 0.00557247297665408 1090 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2285 7945142 200 µM -2.5540309250828 0.0400869544607944 no 3191 0.00532418992553631 1078 2970608 SGTC_1880 MG-132 525 µM -2.56012378722136 0.0397305052385814 no 3192 0.00523174427084557 1061 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_885 0865-0106 16.8 µM -2.56748393304447 0.0393033577229773 no 3193 0.00512197682997224 1081 2793380 SGTC_1218 1348-1416 30.7 µM -2.56845821593401 0.0392470961431972 no 3194 0.00510760132562867 1078 6787668 SGTC_546 peri-Naphthalide 147 µM -2.56946099079521 0.039189257710916 no 3195 0.00509284294238388 1087 223824 A penicillin ester. SGTC_634 1611-4317 11.2 µM -2.57059224442064 0.0391240921288982 no 3196 0.00507623925075588 1091 2843522 SGTC_1663 st014140 55.4 µM -2.573326657002 0.0389669412174639 no 3197 0.00503630447881728 1084 4207120 SGTC_103 0844-0104 51.839 µM -2.57359851084751 0.0389513454878442 no 3198 0.00503234951584923 1068 5375804 SGTC_2248 tofa 1.1 µM -2.57577390886086 0.0388267300964007 no 3199 0.00500080105010216 1070 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1553 gossypol 38.6 µM -2.59794585673308 0.0375750644268759 no 3200 0.00468916400905497 1087 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2949 9072542 2.23 µM -2.60296154670855 0.0372965338756781 no 3201 0.00462111596044558 1079 16457352 SGTC_2531 methyl deoxycholate 70.07 µM -2.60307694332126 0.0372901455918276 no 3202 0.004619560795093 1082 16667744 Haematoxylin. SGTC_1124 fisetin 1.16336 µM -2.60914338064837 0.0369555681499156 no 3203 0.00453846005877667 1080 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_825 1988-2224 89.6 µM -2.61115678429601 0.0368450683963536 no 3204 0.00451182568448586 1083 1180859 SGTC_2246 7293507 91.5585 µM -2.6157287284331 0.0365951537544798 no 3205 0.00445186321665008 1087 887656 SGTC_3004 9076122 71.4286 µM -2.62278738802917 0.0362120334231374 no 3206 0.00436068393475533 1082 44782551 SGTC_1827 berberine 7.24 µM -2.62425674723275 0.036132695914674 no 3207 0.00434191487708813 1051 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2437 5741531 144.16 µM -2.62610922521376 0.036032874948035 no 3208 0.00431835491087648 1068 2262990 SGTC_1948 st076329 66.6 µM -2.63328443346536 0.0356483675999895 no 3209 0.00422817483506611 1089 24208413 SGTC_804 1595-0054 20.9 µM -2.63509245537145 0.0355520110632164 no 3210 0.00420571841483449 1083 761523 Stimulates phospholipase C. SGTC_549 1661-1316 519 µM -2.63930864001534 0.0353281434802751 no 3211 0.00415376547018809 1087 2857282 SGTC_363 0455-0021 3.06 µM -2.64941100803756 0.0347964376278335 no 3212 0.00403161023649703 1059 4597466 SGTC_3260 9137109 49.47 µM -2.66940885448944 0.0337632885688551 no 3213 0.00379924465202752 1081 17478346 SGTC_768 0384-0033 77.3 µM -2.68803002932391 0.0328240847870038 no 3214 0.00359374663043002 1080 3965305 YMR134W ERG29 SGTC_662 k832-1615 104 µM -2.69513354822522 0.0324715240946323 no 3215 0.00351802121118295 1091 5878478 SGTC_1418 3966-3099 2.4 µM -2.71255938102851 0.0316198642219149 no 3216 0.00333829089440676 1087 740335 SGTC_3315 9136395 68.55 µM -2.72212265878326 0.0311603740898043 no 3217 0.00324320311172927 1089 16876844 SGTC_807 1315-0151 48 µM -2.73550951851585 0.0305264612751138 no 3218 0.00311418924837759 1092 4011080 SGTC_1493 4348-0038 111 µM -2.74015658766895 0.0303089200470777 no 3219 0.0030704959642692 1085 800424 SGTC_2143 5623677 140.463 µM -2.74054835921562 0.0302906390836125 no 3220 0.00306683775209941 1082 5375313 SGTC_3039 9090270 49.47 µM -2.7465840146313 0.0300101544361904 no 3221 0.00301097301314181 1083 17173750 SGTC_3246 9135460 32.98 µM -2.74964364740854 0.0298687940389809 no 3222 0.00298300533787068 1087 41446951 SGTC_843 0310-0051 143 µM -2.75108746506279 0.0298022791971719 no 3223 0.0029698890773215 1091 2065037 SGTC_2612 dictamnine 15.46 µM -2.75348821606753 0.0296919517139592 no 3224 0.00294819464281773 1073 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_3086 9117350 49.47 µM -2.77274732886011 0.0288191003324745 no 3225 0.00277926307491921 1089 2679265 SGTC_2766 oltipraz 83.91 µM -2.77680648861819 0.0286378815369064 no 3226 0.00274479257461776 1033 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1339 1486-1321 22.7 µM -2.77758832387557 0.0286030860383639 no 3227 0.0027381976987015 1087 3469382 SGTC_839 0122-0028 230 µM -2.77960043846974 0.0285136987503765 no 3228 0.00272129098644671 1085 759448 SGTC_659 k018-0002 107 µM -2.78167267927101 0.0284218834096709 no 3229 0.00270397762314523 1088 6797879 YHR007C ERG11 SGTC_1941 st076221 61.8 µM -2.78623199118031 0.0282207385568309 no 3230 0.00266623466175051 1075 2828568 SGTC_1404 3909-7820 48.3 µM -2.80385675723205 0.0274542918796618 no 3231 0.0025247666731993 1059 23741373 SGTC_165 k038-0023 64.381 µM -2.81005333939813 0.0271889792693011 no 3232 0.00247666450243493 1087 46368543 SGTC_1607 st000305 50.6 µM -2.81612482318119 0.0269311010141541 no 3233 0.00243033887596763 1090 5457690 SGTC_683 panaxydol 45 µM -2.82484632837065 0.0265642421696128 no 3234 0.00236516483898442 1091 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1989 st071868 50.2 µM -2.83741952878927 0.0260427221409312 no 3235 0.00227399047851986 1084 16414057 SGTC_2754 granisetron 64.02 µM -2.83918160176779 0.0259703224389539 no 3236 0.00226147040104371 1082 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2695 st077686 51.995 µM -2.83973775078849 0.0259475064869539 no 3237 0.00225753177393747 1084 2876092 SGTC_1052 3253-3998 198 µM -2.84230253538094 0.0258425033618466 no 3238 0.00223944835472532 1084 5450317 SGTC_280 3448-3607 3.04 µM -2.84310117127063 0.0258098796332201 no 3239 0.00223384430290247 1069 626179 SGTC_1454 4239-0054 42.6 µM -2.85321223045446 0.0253998217212763 no 3240 0.00216398532994857 1087 1340767 SGTC_813 k007-0158 173 µM -2.87116675476015 0.0246851179961589 no 3241 0.0020447986344046 1091 6523916 SGTC_1652 st011932 78 µM -2.87251450194579 0.0246321567701938 no 3242 0.00203609694279954 1082 1551076 SGTC_164 4100-3994 89.624 µM -2.8790731213708 0.0243757875466772 no 3243 0.00199422923303228 1091 4615967 SGTC_3182 9108849 49.47 µM -2.88033394809865 0.0243267608195715 no 3244 0.00198627074812181 1091 17133045 SGTC_2043 5101342 149 µM -2.88165039136506 0.0242756598488212 no 3245 0.0019779919902915 1092 678451 SGTC_1077 5-fluorocytosine 377 nM -2.88321784863525 0.0242149327477613 no 3246 0.00196817554569725 1093 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_310 1273-0058 1.06 µM -2.88846030704928 0.0240127533884166 no 3247 0.00193566442854368 1063 2734232 SGTC_2068 5226020 147 µM -2.89763808245622 0.0236622208638626 no 3248 0.00187992093844797 1089 1810509 SGTC_2069 5228469 200 µM -2.89816717702447 0.0236421446981018 no 3249 0.00187675227804991 1093 2835210 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -2.89951838934728 0.0235909387798096 no 3250 0.00186868210621967 1091 689007 SGTC_2275 7947463 200 µM -2.90348250576703 0.0234412514963667 no 3251 0.00184518793951642 1073 1225414 SGTC_916 4466-0038 42 nM -2.90416570482874 0.0234155344146096 no 3252 0.00184116605465723 1086 5722064 YGL116W CDC20 SGTC_2324 6149169 200 µM -2.90701824326262 0.0233084150798683 no 3253 0.00182445958271719 1085 2888231 SGTC_637 1181-0519 7.26 µM -2.91211451219656 0.023118065149121 no 3254 0.00179495500990411 1079 6252091 YGR060W ERG25 SGTC_2026 5148700 152 µM -2.91411551072262 0.0230436848702319 no 3255 0.00178348948407941 1094 79838 SGTC_968 1309-0633 340 µM -2.91520211433124 0.0230033786011119 no 3256 0.00177729130226101 1091 3761976 SGTC_305 1682-2595 20.8 µM -2.9221689543608 0.022746360359235 no 3257 0.00173801461742138 1089 226033 SGTC_1202 1988-0068 29.6 µM -2.93164023269498 0.02240083421199 no 3258 0.00168588550022663 1091 2850480 SGTC_2584 androsterone 48.74 µM -2.93776060461066 0.0221799170076831 no 3259 0.00165296096212332 1062 2754130 A steroid. SGTC_2522 biochanin a 4.94 µM -2.93895198282253 0.0221371282151227 no 3260 0.00164662045254052 1088 5280373 A possible chelator. SGTC_327 1273-0057 3.96 µM -2.94122736196197 0.0220556006954155 no 3261 0.00163457241909406 1085 3108138 SGTC_3186 9110464 49.47 µM -2.94886319555115 0.0217838565458379 no 3262 0.00159472563694118 1092 17018021 SGTC_3105 9121040 49.47 µM -2.94982660895846 0.0217497723435509 no 3263 0.00158976156331596 1086 41448907 SGTC_113 0099-0221 2.5 µM -2.97496836466955 0.0208760918067857 no 3264 0.00146509382170031 1088 89219 SGTC_2488 5268135 45.7 µM -3.00923992723016 0.0197331437174315 no 3265 0.00130951099935532 1079 1270356 YLR208W SEC13 SGTC_2954 9074818 52.69 µM -3.02068131315965 0.0193635996642773 no 3266 0.0012610332834423 1088 16648742 SGTC_1230 0170-0365 3.77 µM -3.03465836759742 0.0189201510437631 no 3267 0.00120404145446375 1082 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3205 9113483 49.47 µM -3.04004585464783 0.0187515445103647 no 3268 0.00118271065906796 1085 17018033 SGTC_2891 9063876 19.48 µM -3.04341471233304 0.0186467640082858 no 3269 0.00116954867327808 1095 6472478 SGTC_2929 9013348 24.6 µM -3.05486233404955 0.0182944286737011 no 3270 0.00112581924978253 1084 2995952 SGTC_2814 7977482 42.97 µM -3.06122254334596 0.0181011364930148 no 3271 0.00110217593672268 1093 6456762 SGTC_1786 berberine 21.6 µM -3.06280825277185 0.0180532174479481 no 3272 0.00109635255951983 1048 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2066 5222451 176 µM -3.06438992285816 0.0180055282456136 no 3273 0.00109057212278273 1055 2281147 SGTC_2743 auranofin 4.32 µM -3.08890926977196 0.0172798700574223 no 3274 0.00100446390050688 1090 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3129 9127257 49.47 µM -3.09645525734253 0.0170616331602888 no 3275 0.000979247080088881 1088 837894 SGTC_1636 st007707 68.9 µM -3.10219673370897 0.0168971665121358 no 3276 0.000960451267005366 1089 403051 SGTC_135 0933-0004 26.348 µM -3.11126315765577 0.0166402166054806 no 3277 0.000931444219618436 1088 21230617 YGL099W LSG1 SGTC_454 lyso-paf C-16 6.67 µM -3.11639865345143 0.0164961611950672 no 3278 0.000915372981238742 1090 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_430 0958-0115 16.4 µM -3.13246424955479 0.016052380194974 no 3279 0.000866727684779151 1088 6833180 SGTC_1656 st012921 11 µM -3.13773991816106 0.0159088995747146 no 3280 0.000851279370831907 1090 6732821 SGTC_2876 9059903 25.97 µM -3.14443138632136 0.0157284968833288 no 3281 0.000832049649733596 1087 6916095 SGTC_2752 diclazuril 33.15 µM -3.14631318505389 0.0156780806262405 no 3282 0.000826714255689333 1091 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1059 3448-6867 171 µM -3.14769114629029 0.0156412509338046 no 3283 0.000822827358597029 1092 3934407 SGTC_1047 2043-3044 82 µM -3.17337848239565 0.014968157039945 no 3284 0.000753379806800004 1092 669592 SGTC_2679 rapamycin 1 nM -3.1818965237577 0.0147505236054471 no 3285 0.000731570416480357 1059 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_775 4577-0580 57.3 µM -3.18474478054253 0.0146783612885747 no 3286 0.000724408613238994 1093 2006902 SGTC_1332 1480-0653 17.5 µM -3.19542446288189 0.014410483089645 no 3287 0.000698126634160515 1091 5749438 SGTC_2810 7959871 45.46 µM -3.19902089357814 0.0143212263421015 no 3288 0.000689475874239939 1086 2974535 SGTC_689 0833-0039 98 µM -3.24338924384973 0.0132586651992349 no 3289 0.000590583617239386 1092 5374726 SGTC_2257 7960413 200 µM -3.27975243703221 0.0124392834490341 no 3290 0.000519491066239032 1082 2974689 YIL048W NEO1 SGTC_1660 st012960 28.1 µM -3.28557125976289 0.0123123216335768 no 3291 0.000508878974371625 1094 24207266 SGTC_3010 9080089 71.4286 µM -3.29881827747434 0.0120274630265877 no 3292 0.000485463714686159 1095 17027233 SGTC_3278 9139605 49.47 µM -3.31932273927353 0.0115978130563041 no 3293 0.000451180367347776 1089 7958859 SGTC_3059 1327-0034 3 µM -3.3270994782232 0.0114383801300838 no 3294 0.000438775199963765 1089 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2848 9016370 25.97 µM -3.33569728994053 0.0112643335595362 no 3295 0.00042542878279923 1091 7894410 SGTC_3207 9114163 49.47 µM -3.33768797711009 0.0112243655824004 no 3296 0.000422392787096305 1087 849233 SGTC_2139 5578692 56.4705 µM -3.34779241277749 0.0110233894570356 no 3297 0.000407290011767982 1084 650991 YMR113W FOL3 SGTC_1882 5615643 20 µM -3.35016763597266 0.0109766034718148 no 3298 0.000403813334758287 1093 2253075 SGTC_1731 st035964 63 µM -3.35017918391414 0.0109763764287711 no 3299 0.000403796499203581 1085 6739575 SGTC_101 0490-5701 117.494 µM -3.3625834518244 0.0107348442789993 no 3300 0.000386083914622601 1092 4661669 SGTC_2913 7966556 36.57 µM -3.36470667885727 0.0106939686429792 no 3301 0.000383125357363625 1076 2976516 SGTC_1861 st057647 17.4 µM -3.36761909654103 0.0106381202854947 no 3302 0.000379101352428729 1094 688668 SGTC_39 0986-0283 58.349 µM -3.36888553694281 0.0106139144542298 no 3303 0.000377363820395924 1090 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2651 TUB2.036 5 µM -3.37699630380381 0.0104600256410028 no 3304 0.000366410174237717 1083 15992207 YFL037W TUB2 SGTC_1219 1469-0211 33.1 µM -3.41867309314879 0.00969956452852491 no 3305 0.000314636396538759 1091 6822282 SGTC_1149 3909-7961 23.3 µM -3.44251131554996 0.00928668562373401 no 3306 0.000288169876297322 1093 735261 SGTC_314 1671-0008 2.74 µM -3.44853910702599 0.00918475214617769 no 3307 0.000281813922996615 1086 3913060 SGTC_917 harmaline 728.087 nM -3.45713992847434 0.00904100333462382 no 3308 0.000272970643793847 1081 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2823 7987624 58.44 µM -3.46704857783146 0.00887784219122687 no 3309 0.000263103391477043 1090 2239440 SGTC_470 aa-861 153 µM -3.46949194288279 0.00883800721845375 no 3310 0.000260721853713009 1093 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2525 harmine 47.85 µM -3.47272398357416 0.00878555492335743 no 3311 0.000257602455698162 1092 5280953 A monoamine oxidase inhibitor SGTC_3125 9127534 49.47 µM -3.6224041792779 0.00663684922834851 no 3312 0.000145938797088951 1090 1639235 SGTC_2524 avocatin b 10.57 µM -3.63722146264145 0.00645180762993205 no 3313 0.000137797480903586 1095 6710748 SGTC_3211 9128781 49.47 µM -3.6438987069963 0.00636992317324566 no 3314 0.000134269569502341 1082 17194361 SGTC_593 1203-0218 61.7 µM -3.65496728335056 0.00623621168360514 no 3315 0.000128607388422446 1092 3666956 SGTC_836 0330-0104 1.35 µM -3.6811819778568 0.00592939806194291 no 3316 0.000116077614833281 1094 46494820 SGTC_3072 9116419 49.47 µM -3.68483205520953 0.00588775718358198 no 3317 0.00011442674596084 1087 17170162 SGTC_2504 purpurogallin 52.29 µM -3.74158009936159 0.00527291255192166 no 3318 9.14334368107464e-05 1094 5281571 An antioxidant. SGTC_1654 st012436 41.8 µM -3.7436633709432 0.00525147015749498 no 3319 9.06782952838672e-05 1095 4323132 SGTC_256 clotrimazole 625 nM -3.74734554285556 0.00521376048531019 no 3320 8.93579080408503e-05 1092 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_725 1497-0963 19 µM -3.79875346606506 0.0047118839335975 no 3321 7.27128288608109e-05 1092 3549977 SGTC_2311 7694451 200 µM -3.80376023026143 0.00466538603280071 no 3322 7.12580646716345e-05 1095 2163142 SGTC_1211 1056-0033 32.3 µM -4.02283101515329 0.00299166290191235 no 3323 2.87513772942777e-05 1093 6741922 SGTC_1649 st011737 51.3 µM -4.03869388442967 0.00289464476554975 no 3324 2.68748277397705e-05 1094 1761035 SGTC_3143 9086658 49.47 µM -4.06953441726685 0.0027141019137793 no 3325 2.35535903303554e-05 1089 25236626 SGTC_2223 6903751 107.57 µM -4.07745493640975 0.00266940605840878 no 3326 2.27656754254331e-05 1092 5598863 SGTC_2061 5245884 80.95 µM -4.09758304098347 0.00255879802113696 no 3327 2.08743209577397e-05 1095 573863 SGTC_3238 9133470 49.47 µM -4.10627655614818 0.00251231956110469 no 3328 2.01044020547011e-05 1095 3534688 SGTC_2659 sanguinarine 24.21 µM -4.11719107326812 0.00245504817292597 no 3329 1.91759049676968e-05 1089 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1158 4092-0494 91.8 µM -4.16410500749687 0.00222208873790162 no 3330 1.5628812121966e-05 1095 1148199 SGTC_862 0452-0056 10.2 µM -4.17667456398446 0.00216317214349636 no 3331 1.47900877033997e-05 1094 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_922 1866-0035 480 µM -4.18015679055527 0.00214710254144514 no 3332 1.45654085357571e-05 1092 3156169 SGTC_1212 0520-0165 585 µM -4.18795471921709 0.00211150898244954 no 3333 1.40739828605409e-05 1092 5403258 SGTC_2686 alizarin 95.37 µM -4.20510638141624 0.00203509653977799 no 3334 1.30479691578911e-05 1092 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2827 7993847 71.43 µM -4.23575951239176 0.00190475772980564 no 3335 1.1389023077488e-05 1095 2985692 SGTC_2483 5729050 27.16 µM -4.23628441284086 0.00190259342803637 no 3336 1.13624450582358e-05 1094 2865180 SGTC_1383 3049-0032 20.7 µM -4.24933160335754 0.00184950946995361 no 3337 1.072046609373e-05 1092 712864 SGTC_1161 k007-0610 110 µM -4.39639837261423 0.00133763522089506 no 3338 5.50309277664281e-06 1090 5843850 SGTC_1889 st059080 5.18 µM -4.45983922787936 0.00115981564029856 no 3339 4.1010578260557e-06 1095 176925 Isolated from Daphnopsis sellowiana. SGTC_2689 tacrolimus 100 µM -4.47061113612364 0.00113186774135162 no 3340 3.89982002911947e-06 1088 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2968 9090663 33.37 µM -4.49411986417715 0.00107300417845934 no 3341 3.49291365255446e-06 1090 25236811 SGTC_1330 1469-0054 61.8 µM -4.55827151994052 0.000926363526114306 yes 3342 2.57881661134793e-06 1093 7102664 SGTC_1891 st059073 26.2 µM -4.78256010777996 0.000546491144572863 yes 3343 8.65383043944176e-07 1095 688754 SGTC_2048 5246248 200 µM -4.82002340842856 0.00049931856701489 yes 3344 7.17706888686806e-07 1095 677046 SGTC_1446 4239-0190 62 µM -4.91335239552727 0.000397702510824225 yes 3345 4.47660713122526e-07 1095 1340085 SGTC_436 n,n-dimethylsphingosine 3.3 µM -5.0262882507658 0.000300455312195226 yes 3346 2.50032036368772e-07 1094 5282309 SGTC_525 k781-2675 26.7 µM -5.38952970983951 0.000117413153902409 yes 3347 3.53211506668871e-08 1095 3651118 YDL195W SEC31 SGTC_568 1193-0097 7.48 µM -5.84542647532575 3.32677419323586e-05 yes 3348 2.52636037698675e-09 1093 3646150 SGTC_2024 5144227 134 µM -6.34643629502605 7.48558703302747e-06 yes 3349 1.10179866810158e-10 1094 3475211 SGTC_2986 9022445 71.43 µM -6.36050831170427 7.16694663122622e-06 yes 3350 1.00543586952427e-10 1095 6459286 SGTC_3219 9131112 49.47 µM -6.6573609387908 2.8048527273876e-06 yes 3351 1.39393983141287e-11 1094 17612988 YMR079W SEC14