SGTCid condition conc unit YLR243W|YLR243W.score YLR243W|YLR243W.strain.pval YLR243W|YLR243W.strain.significant YLR243W|YLR243W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_210 3551-0445 56.827 µM 14.2774075037809 1.93577550015848e-60 yes 1 1.51326246222731e-46 2 2865180 YOR207C RET1
SGTC_2004 4023728 41.89 µM 14.073673806758 8.61910993076665e-59 yes 2 2.75647013542166e-45 2 360084 YDR527W RBA50
SGTC_611 3453-1652 23.7 µM 13.3393119400513 4.82199019521745e-53 yes 3 6.83577737090011e-41 2 1560575
SGTC_2466 5983409 37.09 µM 10.1895806240407 7.61915137616064e-32 yes 4 1.10357133945036e-24 1 2879657
SGTC_2430 5571206 200 µM 10.0339877304138 6.08234941108245e-31 yes 5 5.40310437006363e-24 2 1731771
SGTC_897 1000-0139 31.4 µM 8.47976327168293 1.11680037886387e-22 yes 6 1.1282629544462e-17 2 6151020
SGTC_2233 sulbentine 40.3845 µM 8.25146737580032 1.40425795544807e-21 yes 7 7.82306758665498e-17 15 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2408 sulbentine 18.36 µM 6.43437869289679 7.19136494238808e-14 yes 8 6.19897031846922e-11 16 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2780 5215298 71.43 µM 5.91059771021598 5.45030950162941e-12 yes 9 1.70434291345907e-09 5 2834131
SGTC_2323 6148992 148.28 µM 5.85411632184643 8.51100651752254e-12 yes 10 2.39776454592014e-09 7 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2480 5767542 37.17 µM 5.59009573545971 6.4750985851399e-11 yes 11 1.13472227281143e-08 1 2867358
SGTC_2246 7293507 91.5585 µM 5.29649240189111 5.56932777336081e-10 yes 12 5.90241240493548e-08 5 887656
SGTC_2921 7974240 10.71 µM 4.76869437793804 2.02201835863458e-08 yes 13 9.27118550738645e-07 10 2979074 YDR527W RBA50
SGTC_2456 5770359 74.46 µM 4.74344458154966 2.37989444418393e-08 yes 14 1.05057221745467e-06 1 3118787
SGTC_2151 5563267 85.4165 µM 4.65386802349116 4.21499198088369e-08 yes 15 1.62882678654693e-06 13 5310824
SGTC_589 1227-0070 34.1 µM 4.62870341288484 4.94013444178777e-08 yes 16 1.83981157947381e-06 6 2841384
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 4.5409178265069 8.54103213460814e-08 yes 17 2.80049302109563e-06 9 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2612 dictamnine 15.46 µM 4.47617851643464 1.27099434924769e-07 yes 18 3.79954762099451e-06 23 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2470 5664817 21.68 µM 4.26100944878637 4.5852979152174e-07 yes 19 1.0175281405476e-05 3 2859561
SGTC_3317 9138495 8.753 µM 3.87575428290701 3.94193172892538e-06 yes 20 5.31474544737395e-05 11 17020139
SGTC_87 0100-0052 35.5 µM 3.83442760889001 4.91047361879297e-06 yes 21 6.2928515294342e-05 17 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_808 0711-0032 135 µM 3.79631576841653 6.00192749822263e-06 yes 22 7.34312060544622e-05 10 4252555
SGTC_2479 5617353 43.85 µM 3.77112257268936 6.84663485982986e-06 yes 23 8.12574088848802e-05 7 2731746
SGTC_2487 5918373 44.05 µM 3.76977279356581 6.89495288946011e-06 yes 24 8.16981140664302e-05 7 2876279
SGTC_3207 9114163 49.47 µM 3.76216970372015 7.17325461362326e-06 yes 25 8.42228424795128e-05 13 849233
SGTC_2949 9072542 2.23 µM 3.76156383138568 7.19588677251111e-06 yes 26 8.44271579969702e-05 15 16457352
SGTC_150 3970-0969 77.2 µM 3.73355419807536 8.31979813408837e-06 yes 27 9.4398271959254e-05 20 6615640
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 3.68046279924976 1.09247345177006e-05 yes 28 0.000116405511994185 13 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3327 9140648 26.9345 µM 3.44897787875113 3.4382212737888e-05 yes 29 0.000281356399358411 23 8029710
SGTC_1643 st009866 20.2 µM 3.44170686858209 3.56044016460631e-05 yes 30 0.000289028142732962 27 3156273 YOR207C RET1
SGTC_3212 9128307 49.47 µM 3.43012411433744 3.76365962599109e-05 yes 31 0.000301652610335057 18 27243542
SGTC_2139 5578692 56.4705 µM 3.3359860059415 5.87283585790284e-05 yes 32 0.000424987211040732 23 650991 YMR113W FOL3
SGTC_3282 9108498 15.4605 µM 3.32199659440327 6.26838731661023e-05 yes 33 0.000446878923602426 20 16459645
SGTC_421 streptovitacin 30 mM 3.32025818347893 6.31925927707882e-05 yes 34 0.000449671168446774 5 91467 include heat shock
SGTC_428 3448-4153 16.5 µM 3.2869597660662 7.37209376682758e-05 yes 35 0.000506376511014215 15 3834874
SGTC_1012 4112-3522 18 µM 3.26836652870925 8.02972155734706e-05 yes 36 0.00054085091590195 6 3112398
SGTC_807 1315-0151 48 µM 3.2395893797801 9.15733054857476e-05 yes 37 0.000598509718585224 18 4011080
SGTC_2474 5321570 43.32 µM 3.21512583389494 0.000102313398685819 yes 38 0.000651936761869842 9 2841384
SGTC_2288 7946289 167.31 µM 3.08033894099034 0.000186009050373568 yes 39 0.00103382574324288 14 1246052
SGTC_622 1348-1566 26.3 µM 3.07467670319016 0.000190645396262683 yes 40 0.00105365423834314 13 7340407
SGTC_2999 9069765 71.4286 µM 2.98946327462415 0.000274830974687569 yes 41 0.00139734020783373 10 2097066
SGTC_2483 5729050 27.16 µM 2.87425089285539 0.000444278093543761 yes 42 0.00202493553201069 24 2865180
SGTC_1040 k898-0338 155 µM 2.83017502208121 0.000531596687889549 yes 43 0.00232612733448292 8 20969351
SGTC_1042 0350-0096 82 µM 2.8112939532273 0.000573651782550221 yes 44 0.00246713416336849 19 3122515
SGTC_1895 st058434 18.3 µM 2.77617795667207 0.000660149897851755 yes 45 0.002750104710021 21 5393175
SGTC_2104 5389443 200 µM 2.76192289996197 0.000698579468769795 yes 46 0.00287310230010794 24 2244536
SGTC_1907 st060210 83.7 µM 2.71749906865316 0.000831961999438358 yes 47 0.00328886702603515 21 688793
SGTC_1912 st060209 90.8 µM 2.70045374082008 0.000889086033756294 yes 48 0.00346224829489576 29 688787
SGTC_639 0833-0042 114 µM 2.6879441538657 0.000933279733050133 yes 49 0.00359467096817685 22 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3202 9113761 49.47 µM 2.64691116777224 0.00109278935838609 no 50 0.0040615344082494 34 4798415
SGTC_2067 5224629 34.075 µM 2.6323001937462 0.00115537172428902 no 51 0.00424044454364018 27 2835000
SGTC_3030 9087619 49.47 µM 2.62562907844245 0.00118502309310921 no 52 0.0043244504606091 31 25236973
SGTC_1458 k015-0034 6.33 µM 2.62332835323438 0.00119540971381533 no 53 0.00435376542631401 18 3598957
SGTC_251 melphalan 456.522 µM 2.61671196082509 0.00122574558726526 no 54 0.00443906119935641 26 460612 A DNA alkylator.
SGTC_1212 0520-0165 585 µM 2.61607700664663 0.00122869356481146 no 55 0.00444732474999119 31 5403258
SGTC_826 1683-5028 118 µM 2.61169660989689 0.00124920836883069 no 56 0.00450470835227047 18 722377
SGTC_774 k060-0086 136 µM 2.60443237679192 0.00128392088507699 no 57 0.00460132895846748 25 5911235
SGTC_2799 7812892 81.82 µM 2.60363832168428 0.00128776831883181 no 58 0.00461200192905946 42 20205235
SGTC_3236 9132701 49.47 µM 2.5949177981303 0.00133072099767269 no 59 0.00473067721163285 22 24282524
SGTC_780 0109-0199 192 µM 2.58851033683575 0.00136311091067864 no 60 0.0048196026956034 29 610414
SGTC_323 4013-0906 34.3 µM 2.58768882039516 0.00136731539259731 no 61 0.00483111117224119 12 2910086
SGTC_1142 3253-1408 9.78 µM 2.58173783033435 0.00139812779925632 no 62 0.00491521156554219 13 256655
SGTC_749 1000-0129 128 µM 2.55093198813331 0.00156800861681201 no 63 0.00537176444405306 21 708470
SGTC_3060 1327-0027 12.5 µM 2.54208369330323 0.00162016949275661 no 64 0.00550968920310278 20 16000455 YPR107C YTH1
SGTC_38 0929-0051 58.268 µM 2.5206325511375 0.00175325045753402 no 65 0.00585720542459532 28 1379719
SGTC_1717 st033143 58.0435 µM 2.49614404997718 0.00191728222125975 no 66 0.00627758022823273 22 674616
SGTC_51 1013-0126 23.419 µM 2.47364582049328 0.00208014504651665 no 67 0.00668711060226672 23 1627850
SGTC_1423 4048-0112 5.59 µM 2.46313110021906 0.00216048132173713 no 68 0.00688647725739649 16 X1423
SGTC_1757 st041620 31.8375 µM 2.44858031789019 0.00227629588059813 no 69 0.00717102249787155 13 5289815
SGTC_2019 4016004 108 µM 2.42264915699923 0.00249671361396336 no 70 0.00770389954697306 38 45595336
SGTC_2275 7947463 200 µM 2.42000454002739 0.00252024439358009 no 71 0.00776015666365579 39 1225414
SGTC_269 exalamide 29 µM 2.41995593315312 0.00252067874893803 no 72 0.00776119401871489 29 3316 A derivative of salicylamide.
SGTC_2421 5690543 90.72 µM 2.40680326940015 0.00264072960951785 no 73 0.00804641814366414 32 3397993
SGTC_1773 st048542 73.5835 µM 2.36903114338027 0.00301474183039401 no 74 0.00891737580746203 87 3237138
SGTC_3329 9141233 27.5565 µM 2.35675440171451 0.00314620342367149 no 75 0.0092177175450138 25 4909101 YNL103W MET4
SGTC_1374 2889-5571 141 µM 2.34758974523148 0.00324767997018141 no 76 0.00944766027457757 81 2853281
SGTC_1255 0566-0045 221 µM 2.34660359219748 0.00325877283993508 no 77 0.00947269945494586 43 2788469
SGTC_1938 st074717 56.4 µM 2.32176094616628 0.00354970112572099 no 78 0.010122905607888 14 17250979
SGTC_128 0906-2981 13.371 µM 2.29604559237843 0.00387521015383764 no 79 0.0108366373329987 51 6740226
SGTC_2163 5671233 125 µM 2.29215881524626 0.00392667078362344 no 80 0.0109482402605162 51 701023
SGTC_1751 st044839 27.194 µM 2.28556607352758 0.00401535935579222 no 81 0.0111398284231641 22 5291326
SGTC_253 dyclonine 31.25 µM 2.28451226864996 0.00402970068632527 no 82 0.0111707211951981 36 3180 An oral anasthetic.
SGTC_968 1309-0633 340 µM 2.28450800526434 0.00402975880016449 no 83 0.0111708463294345 34 3761976
SGTC_1464 k208-0027 110 µM 2.27938430628478 0.00410014420121267 no 84 0.0113221152001369 34 X1464
SGTC_2958 9077254 16.72 µM 2.27513962301033 0.00415928548393669 no 85 0.011448777699781 38 16457351
SGTC_1132 3456-3614 2.5 µM 2.26853257350427 0.00425286096711076 no 86 0.0116483829908441 38 3125502
SGTC_763 3453-1109 128 µM 2.26450025504627 0.00431089138415707 no 87 0.0117716820439795 33 1560353
SGTC_3006 9075424 71.4286 µM 2.24861948942837 0.00454638008752295 no 88 0.012268357687451 35 7465181
SGTC_2021 4019055 173 µM 2.24701611519483 0.00457078270094767 no 89 0.0123194986119907 83 44827708 YER133W GLC7
SGTC_378 3970-0959 8.33 µM 2.22054926245147 0.00499084052498849 no 90 0.0131907527826992 39 6615653
SGTC_1034 k072-0165 12.7 µM 2.21846296635334 0.00502537052778629 no 91 0.0132616409873579 38 5835461
SGTC_3189 9110682 49.47 µM 2.21765297286115 0.00503883385229927 no 92 0.0132892515170067 42 17122418
SGTC_803 4488-1585 147 µM 2.21614971395693 0.00506390544938364 no 93 0.0133406252332946 30 747204
SGTC_2035 5154463 94.595 µM 2.21373960703495 0.00510433345329177 no 94 0.0134233483327318 52 2769623
SGTC_2667 digitoxin 100 µM 2.20454378747414 0.00526123972970796 no 95 0.0137430620250319 13 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2405 ticlatone 3.52 µM 2.17531883373857 0.00578876382551069 no 96 0.0148031160682779 52 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2350 9023895 38.85 µM 2.1725894013555 0.00584035021506155 no 97 0.0149056171466338 46 2997209
SGTC_366 0181-0206 4.31 µM 2.14335517010593 0.0064189850961611 no 98 0.0160422949611715 45 274874
SGTC_1043 0916-0009 19.3 µM 2.13222153324953 0.00665235240260342 no 99 0.0164943195327434 48 3101130
SGTC_799 1310-0557 151 µM 2.11198648710429 0.00709575057424839 no 100 0.0173438041701563 55 5354492
SGTC_1748 st037455 53.6035 µM 2.11147824994172 0.00710721524944664 no 101 0.0173656127377177 45 580690
SGTC_1396 3511-0007 98.6 µM 2.1060587736631 0.00723048631686201 no 102 0.0175996236689785 44 X1396
SGTC_705 1124-0212 310 µM 2.09821961811252 0.00741213084652215 no 103 0.0179428746898703 51 9554485
SGTC_3231 9132313 49.47 µM 2.08703914650674 0.00767815325249606 no 104 0.0184422980381632 41 4905967
SGTC_1141 3253-0389 52.6 µM 2.08561637555899 0.00771260168576508 no 105 0.0185066933998586 45 5402031
SGTC_1232 0279-0259 161 µM 2.0768669856106 0.00792744944548769 no 106 0.0189069187979068 41 1560000
SGTC_1221 2958-7315 257 µM 2.07140721676574 0.0080641695175073 no 107 0.0191603785249033 51 4562705
SGTC_268 camptothecin 39.6153 µM 2.07120581642198 0.00806925225332357 no 108 0.0191697831426342 107 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_265 mycophenolic acid 32.932 µM 2.02940884978203 0.00918695972122104 no 109 0.0212083322358413 38 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2411 st077133 39.94 µM 2.02099407936101 0.00942769789851012 no 110 0.0216401889941025 70 1403142 YNL221C POP1
SGTC_1058 3448-5425 97.3 µM 2.0208689969679 0.00943131760839146 no 111 0.0216466640160221 62 7279705
SGTC_3251 9135047 49.47 µM 2.00677914173831 0.00984691778269207 no 112 0.0223865923827959 31 17682963
SGTC_1999 st074831 12.5 µM 2.00476355544639 0.00990765933927201 no 113 0.0224941652037987 63 17112523
SGTC_1390 3413-2614 145 µM 1.99420352358933 0.0102312717045766 no 114 0.0230649086245524 57 3421432
SGTC_2811 7967822 32.47 µM 1.99375303297195 0.0102452796924353 no 115 0.0230895252994467 51 2232244
SGTC_3024 9090631 49.47 µM 1.98786570416754 0.010429889354083 no 116 0.0234132723282387 29 25236383
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.98428516122566 0.0105435771096195 no 117 0.0236120297221947 83 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2852 9023854 51.95 µM 1.98267900006214 0.0105949250071551 no 118 0.0237016483717275 59 19798528
SGTC_1954 st077032 68.9 µM 1.97908596458385 0.0107105812851993 no 119 0.023903164213306 47 698907
SGTC_1982 st072467 71.9 µM 1.97409917910956 0.0108729220174923 no 120 0.0241852333394137 61 3163533
SGTC_1333 1482-0047 286 µM 1.97269658230547 0.0109189665453339 no 121 0.0242650707950962 49 3811116
SGTC_3162 9099653 49.47 µM 1.95605114363693 0.0114784926547894 no 122 0.025229564819351 36 25237511
SGTC_3214 9129694 49.47 µM 1.95471430269993 0.0115244914691496 no 123 0.025308400483087 63 17158655
SGTC_2849 9019321 12.99 µM 1.95317538973667 0.0115776414411391 no 124 0.025399408089682 55 16489627
SGTC_1906 st060206 94.7 µM 1.95036911987955 0.0116751106766022 no 125 0.0255660698462672 49 5133468
SGTC_3064 1327-0027 10 µM 1.92978628811398 0.0124120261943101 no 126 0.0268166615773452 33 16000455 YPR107C YTH1
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.91463137966608 0.0129800486492276 no 127 0.0277697651737164 60 5106787 A p450 inhibitor.
SGTC_1676 st018489 23.4 µM 1.91424297203857 0.0129948972309746 no 128 0.0277945586857634 50 3696235
SGTC_2707 st078556 66.6 µM 1.9113253904667 0.0131069047563054 no 129 0.0279813890516845 44 17250899
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.90766146144182 0.0132487460342192 no 130 0.0282174928967501 52 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_272 doxorubicin 8.13 µM 1.90000008852655 0.0135496306586523 no 131 0.0287165540072608 64 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2052 5265182 7.135 µM 1.87481315787612 0.0145807237762831 no 132 0.0304092161905629 64 1239884
SGTC_694 1315-0438 43.2 µM 1.84826777327117 0.0157398156058036 no 133 0.0322818076690555 49 6793154
SGTC_2451 5856223 45.7 µM 1.84265786562284 0.0159946391995611 no 134 0.0326894897465551 85 2179896
SGTC_3049 9092223 49.47 µM 1.83619670523608 0.016292504230749 no 135 0.0331642848978654 48 8623917
SGTC_2443 5493264 126.67 µM 1.83515531174545 0.0163409552435625 no 136 0.0332413401989455 48 5340055
SGTC_12 0849-0099 9.267 µM 1.82611514728443 0.0167667594253118 no 137 0.0339164595199805 62 6071388
SGTC_2354 9060492 162 µM 1.82174988523516 0.0169757445469525 no 138 0.0342464724722202 58 6471895
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.81026147200094 0.0175364187711923 no 139 0.0351276243932228 80 65057 A dermal irritant. YDR527W RBA50
SGTC_164 4100-3994 89.624 µM 1.8082013494502 0.0176386136230169 no 140 0.0352875843431097 72 4615967
SGTC_948 3448-0295 75.3 µM 1.80780796760533 0.0176581854854644 no 141 0.0353181966408266 68 678569
SGTC_2709 st078560 56 µM 1.80733280643273 0.0176818508115504 no 142 0.0353552019055865 72 17250903
SGTC_2601 securinine 100 µM 1.80327517545474 0.0178850450829301 no 143 0.0356725046494412 99 442872 A GABA receptor antagonist.
SGTC_1923 st058458 19.1 µM 1.8006584331327 0.0180171374473275 no 144 0.0358783665092886 74 3534982
SGTC_376 3970-0862 59.1 µM 1.77590781640368 0.0193082023955785 no 145 0.0378740562118027 87 3135186
SGTC_885 0865-0106 16.8 µM 1.77483981374432 0.0193656382237699 no 146 0.037962170172711 76 2793380
SGTC_567 1080-0542 68.4 µM 1.76258267140298 0.0200352710530474 no 147 0.0389854509105653 58 5950415
SGTC_3062 9077494 49.47 µM 1.76132065427509 0.0201053198243686 no 148 0.0390920730727339 66 16459633
SGTC_368 fentichlor 4.58 µM 1.75994122363897 0.0201821231689193 no 149 0.0392088863912366 67 7329 A pesticide.
SGTC_2118 5526350 200 µM 1.75279804842385 0.0205838289206315 no 150 0.039818339135846 75 743594
SGTC_85 0868-0259 160.055 µM 1.74699468386595 0.0209151563657119 no 151 0.0403191301311392 65 83173
SGTC_1671 st016596 74.5 µM 1.73579205983813 0.0215675168697101 no 152 0.0413003042891271 69 2829167
SGTC_364 0083-0097 67.7 µM 1.72352875617604 0.0223012765921612 no 153 0.0423964747918481 71 5207356
SGTC_697 0508-1955 564 µM 1.71876021025324 0.0225922289993903 no 154 0.04282902173493 70 6243113
SGTC_3315 9136395 68.55 µM 1.71640637317086 0.0227370238139469 no 155 0.0430438454606741 99 16876844
SGTC_3065 9113888 49.47 µM 1.7039745295057 0.0235147958778699 no 156 0.0441929228953803 76 16648368
SGTC_1085 doxorubicin 7.67 µM 1.69813384215187 0.0238878636118553 no 157 0.0447412517755573 93 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1661 st013063 9.66 µM 1.6972267250352 0.0239462487200107 no 158 0.0448269021781998 82 721395
SGTC_551 k048-0028 34.9 µM 1.69506070797381 0.0240861460792907 no 159 0.0450319524924977 91 6836383
SGTC_1338 1486-1223 76 µM 1.69369218295256 0.0241748889959402 no 160 0.045161895331703 71 3444526
SGTC_3146 9095609 49.47 µM 1.69305930435761 0.0242160212073834 no 161 0.0452220897364739 65 17173999
SGTC_594 1487-1584 10.8 µM 1.68557810243027 0.024706711348541 no 162 0.0459385449174391 81 5013332
SGTC_1148 3909-7663 27.7 µM 1.68555827607168 0.024708022755037 no 163 0.0459404556824688 61 4084526
SGTC_177 1327-0068 8.361 µM 1.68469766180047 0.0247650040482399 no 164 0.0460234589347257 97 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_41 0478-0632 82.643 µM 1.68455903770584 0.0247741926528232 no 165 0.0460368400050315 87 3750424
SGTC_2634 4'-methoxyflavone 100 µM 1.67882558920854 0.0251567431327013 no 166 0.0465930199660591 71 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2225 6654152 15.4 µM 1.67606337696814 0.0253428048551582 no 167 0.0468628896581277 100 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.6757310070931 0.025365270689595 no 168 0.0468954467169565 74 5379071
SGTC_2289 7946404 165.07 µM 1.67558235957194 0.0253753236002032 no 169 0.0469100132506077 102 1246120 YPR165W RHO1
SGTC_290 2043-6722 48.1 µM 1.67393067487048 0.0254872504297602 no 170 0.0470721123792256 68 773758 YLR208W SEC13
SGTC_2346 9031566 143.75 µM 1.67182497541572 0.0256305429418438 no 171 0.0472794201830082 66 4771086
SGTC_1000 4048-0884 8.67 µM 1.66978882402343 0.0257697435082311 no 172 0.0474805761698104 80 13040088
SGTC_1781 st038725 66.3 µM 1.66903708247099 0.025821295646179 no 173 0.0475550154892437 84 4270275 YIL048W NEO1
SGTC_964 1287-0107 19.4 µM 1.66373941509252 0.0261870458534389 no 174 0.0480822579563757 92 51516812 YPR165W RHO1
SGTC_2588 indole-3-carbinol 100 µM 1.66036491910193 0.0264222714556525 no 175 0.0484205314956434 83 3712 Induces cell cycle arrest.
SGTC_1210 3013-0140 750 nM 1.65909496366758 0.0265112522119679 no 176 0.0485483289896855 69 905973
SGTC_3087 9117406 49.47 µM 1.65058799286007 0.0271137796882401 no 177 0.0494113661514168 73 42546093
SGTC_2963 9082507 9 µM 1.64763817397886 0.0273253581428274 no 178 0.049713471006851 88 16459611
SGTC_141 0443-0274 32.331 µM 1.64634342284019 0.0274186592586645 no 179 0.0498465371106974 70 1627241
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.64058083193108 0.0278371457132844 no 180 0.0504422283043968 76 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1493 4348-0038 111 µM 1.64000239040371 0.0278794451825053 no 181 0.0505023349656024 123 800424
SGTC_1112 tnp00069 1.16933 µM 1.63433640688878 0.0282966172030642 no 182 0.0510941165759845 67 145826
SGTC_1970 st070122 35.8 µM 1.63359909270746 0.0283512838618648 no 183 0.0511715292334109 105 102928
SGTC_1354 1498-1681 81 µM 1.62976501822798 0.0286369721428891 no 184 0.0515755849049938 87 5754243
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.62751789123547 0.0288055222781284 no 185 0.0518135759644118 78 5355888
SGTC_2647 atorvastatin 60.16 µM 1.62740860430376 0.028813740543907 no 186 0.0518251726575214 59 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3174 9107204 49.47 µM 1.6260415697967 0.0289167049338631 no 187 0.0519704062487065 63 3938802
SGTC_2763 lisinopril 49.32 µM 1.62573033258398 0.0289401898631718 no 188 0.0520035172063285 70 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.6185343683219 0.0294876090826727 no 189 0.0527737431722055 97 688662
SGTC_315 k915-0449 187 µM 1.59500480317585 0.0313378982823857 no 190 0.0553555808497493 74 20970215 YNL149C PGA2
SGTC_2629 bisabolol 100 µM 1.59258728253517 0.0315333276891707 no 191 0.055626404180993 116 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_655 k060-0012 42 µM 1.58732401991247 0.0319622886639671 no 192 0.0562196388946846 99 5994525
SGTC_1388 3346-4487 254 µM 1.58414900701951 0.0322233776920768 no 193 0.0565799071580569 88 3345614
SGTC_1810 st050138 53 µM 1.58328368889977 0.0322948393803994 no 194 0.0566784094667349 105 3444541
SGTC_468 gf-109203x 121 µM 1.58241127489259 0.0323670194291204 no 195 0.0567778562370375 40 2396 A protein kinase C inhibitor.
SGTC_2370 9071495 200 µM 1.57613162068322 0.0328905095338645 no 196 0.0574977365488255 94 21791103
SGTC_16 erodoxin 22.806 µM 1.57093115828641 0.0333293001196148 no 197 0.0580993201034994 129 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_296 1222-0039 74.9 µM 1.56730983028538 0.0336376891269727 no 198 0.058521144367632 72 5984176
SGTC_1031 k035-0009 16 µM 1.56460904877276 0.0338692108551732 no 199 0.0588373029353388 87 5180959
SGTC_2994 9053520 71.4286 µM 1.56140437473733 0.0341456270973465 no 200 0.0592141851659289 76 4647384
SGTC_1359 1582-0056 520 nM 1.56045766329799 0.0342276388078793 no 201 0.0593258836387481 81 3661189
SGTC_2277 7947813 106.88 µM 1.55844648372583 0.0344024006533921 no 202 0.0595637224080205 87 1246798
SGTC_889 0919-1524 82.7 µM 1.54762795221047 0.0353551014979766 no 203 0.0608559487751845 76 3905452
SGTC_374 0880-0231 82.3 µM 1.54537172004226 0.0355564919213419 no 204 0.061128188333878 106 6833587
SGTC_1315 1237-0019 3.69 µM 1.54448687329662 0.0356357293066839 no 205 0.0612352144314675 83 825140
SGTC_2717 st081029 62.2815 µM 1.54227304192122 0.0358346105143194 no 206 0.0615036285079783 82 5292846
SGTC_540 1187-0821 17.3 µM 1.5400809235272 0.0360324362957383 no 207 0.0617703145661732 103 847520
SGTC_979 1426-2828 121 µM 1.53548123745825 0.0364504387352896 no 208 0.062332831185105 98 747872
SGTC_1854 st056233 32.9 µM 1.5333620342906 0.0366443550039994 no 209 0.0625933388474157 101 5393174
SGTC_206 4546-0025 72.014 µM 1.53038504400956 0.036918187097942 no 210 0.0629607243786225 96 6620745 YIL048W NEO1
SGTC_169 k015-0017 16.025 µM 1.52154300490795 0.037741380401683 no 211 0.0640618139514843 97 1840002
SGTC_1013 4112-3890 241 µM 1.51969077910445 0.0379157066341702 no 212 0.0642943550832415 109 705171
SGTC_717 1532-0246 73.2 µM 1.51440452039856 0.0384168503019932 no 213 0.0649616367408068 95 9561992
SGTC_286 k060-0067 22.9 µM 1.50965261290887 0.038871932761663 no 214 0.0655660443844383 105 5985051
SGTC_2866 9034245 58.44 µM 1.50835886081445 0.0389965908254821 no 215 0.0657313530248918 72 6462273
SGTC_2859 9028643 45.46 µM 1.50574173840803 0.0392497559987043 no 216 0.0660667424104598 64 17151580
SGTC_1759 st043059 70 µM 1.50573365947532 0.0392505395734837 no 217 0.0660677797903845 105 669426
SGTC_1207 2099-0101 141 µM 1.50153273732655 0.0396597142144178 no 218 0.0666089129235258 102 5837381
SGTC_3181 9108277 49.47 µM 1.50122203947933 0.0396901137865271 no 219 0.0666490706687183 108 17097298
SGTC_625 k213-0058 121 µM 1.48236097593306 0.0415713129514436 no 220 0.0691221358525482 140 3655420
SGTC_2357 9067248 200 µM 1.48145798350615 0.041663158972943 no 221 0.0692422866766599 94 9150235
SGTC_762 1165-0429 115 µM 1.48117628309563 0.0416918451658622 no 222 0.0692798022215771 106 5967793
SGTC_328 k915-0120 63.5 µM 1.47688281345218 0.0421310422211352 no 223 0.0698535263316563 75 6624543
SGTC_1874 staurosporine 7.6 µM 1.47577024493997 0.0422454603070405 no 224 0.0700027905649813 101 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1489 4065-0444 182 µM 1.47547928733949 0.0422754242260252 no 225 0.0700418664216382 88 2877968
SGTC_957 1187-1561 14.1 µM 1.4753369236474 0.0422900916436194 no 226 0.070060992101436 103 1538454
SGTC_2437 5741531 144.16 µM 1.4751246805707 0.0423119662244368 no 227 0.0700895131030696 121 2262990
SGTC_3059 1327-0034 3 µM 1.47306706036132 0.0425245072749837 no 228 0.0703664771523762 100 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_986 1493-0483 84 µM 1.46793452443258 0.0430584347216689 no 229 0.071061004543534 97 40079
SGTC_1732 st034308 51.822 µM 1.4668782990074 0.0431689808799844 no 230 0.0712045824290426 107 830119
SGTC_1573 oleylamine 1.06 µM 1.46499168614265 0.0433670069723032 no 231 0.0714615930218436 102 5356789 An amine of the fatty acid oleic acid.
SGTC_503 tyrphostin 8 294 µM 1.46208655856806 0.0436733738431884 no 232 0.0718587458129442 112 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3341 9147222 25.867 µM 1.46135065825457 0.0437512564847539 no 233 0.071959617119645 103 1939759
SGTC_2931 9014674 55.67 µM 1.45980542705446 0.0439151578296891 no 234 0.072171778304652 93 2996810
SGTC_1730 st033808 45.1 µM 1.45745172207437 0.0441657645968197 no 235 0.0724958643396679 96 1045166
SGTC_1472 k841-0093 193 µM 1.45594228000189 0.0443270857662207 no 236 0.0727042882153637 87 X1472
SGTC_974 1326-0144 138 µM 1.45466155282046 0.0444643352005213 no 237 0.0728814906921348 105 5411856
SGTC_3052 9092717 49.47 µM 1.45398635209158 0.0445368309681127 no 238 0.0729750450309621 97 25237534
SGTC_591 4299-0174 154 µM 1.44621305575665 0.0453783204187857 no 239 0.0740587264660199 88 5509088
SGTC_673 1082-0474 110 µM 1.44465860182734 0.0455481207844933 no 240 0.0742769017513737 161 3098046
SGTC_1952 st077036 64.1 µM 1.4440183149537 0.0456182107424952 no 241 0.0743669117725154 117 2937007
SGTC_513 4245-1575 41.7 µM 1.44390002446271 0.0456311690721373 no 242 0.0743835498819432 139 719745
SGTC_869 0564-0080 44.1 µM 1.44079110211008 0.045972803368306 no 243 0.0748218539876092 82 6843321
SGTC_1630 st005209 31.3 µM 1.43591124604134 0.0465131837749469 no 244 0.0755137989938006 99 3367314
SGTC_3061 glucosamine 200 µM 1.43451971402432 0.0466682084321226 no 245 0.0757120037076564 86 91431 and experimental redox chemotherapeutic
SGTC_1284 0929-0043 16 µM 1.43337233189977 0.0467963449987978 no 246 0.0758757305001596 106 1239883
SGTC_1989 st071868 50.2 µM 1.42178305415563 0.0481064858899356 no 247 0.0775446202402016 116 16414057
SGTC_102 gallobenzophenone 83.616 µM 1.42053362461703 0.048249466745507 no 248 0.0777261933492591 110 70837
SGTC_518 1021-0119 62.6 µM 1.4192448945462 0.0483973010107494 no 249 0.0779138157344742 120 1097762
SGTC_2712 st079126 47.7 µM 1.40986846535468 0.0494838359040415 no 250 0.0792892628325298 92 3152970
SGTC_533 1222-0222 6.71 µM 1.40882421231041 0.049606038851974 no 251 0.0794435769237704 119 3982874
SGTC_670 4204-0025 119 µM 1.40532547350463 0.0500172321908213 no 252 0.0799622584167691 94 719039
SGTC_1523 st012844 44.7 µM 1.40348762324344 0.0502343139514266 no 253 0.08023574007551 82 4274103
SGTC_4 0960-0234 25.671 µM 1.4030300499505 0.0502884778318015 no 254 0.0803039391414623 100 6821112
SGTC_1138 3761-0006 1.03 µM 1.39621747232689 0.0511004143329912 no 255 0.0813245083702195 87 12061087
SGTC_1451 4152-0210 104 µM 1.39454658394911 0.0513011388512349 no 256 0.0815763062752137 105 659563
SGTC_1322 1348-1070 12 µM 1.39287751694117 0.051502270268514 no 257 0.0818284161510787 108 6758089
SGTC_781 4335-2806 94.4 µM 1.3896250126785 0.0518960155574891 no 258 0.082321388142173 124 845254
SGTC_1275 0867-0008 21.1 µM 1.38843611165637 0.0520405384637528 no 259 0.082502143267912 101 3422836
SGTC_2506 ethyl hematommate 54.16 µM 1.3867154044058 0.0522502738378397 no 260 0.0827642807262435 84 3940691 An allergen.
SGTC_2607 solasodine 47.35 µM 1.38656775519361 0.0522683018865802 no 261 0.082786803192351 143 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_535 2293-4129 48.2 µM 1.38531794803797 0.0524211019559845 no 262 0.0829776340122163 140 396118 YIL048W NEO1
SGTC_2585 alliin 100 µM 1.38492081903836 0.0524697286923986 no 263 0.083038340148411 101 87310 A garlic compound which reacts with lipids.
SGTC_1411 3909-8223 150 µM 1.37985791481405 0.0530928026215924 no 264 0.0838151983305101 124 X1411
SGTC_2851 9015922 71.43 µM 1.37875603666216 0.0532291812001741 no 265 0.083984992860583 129 2996893
SGTC_2439 5492030 7.2 µM 1.36852674973554 0.0545085461979662 no 266 0.0855736274021446 116 5722370
SGTC_1470 k295-0292 231 µM 1.36743866326023 0.0546460509082948 no 267 0.0857439252708047 127 5045612
SGTC_291 SEC14.278 35.5 µM 1.36553868853761 0.0548868137797648 no 268 0.0860419009315294 108 1068044
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.36405546110531 0.0550753489270489 no 269 0.0862750555211051 94 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1068 loratadine 26.9 µM 1.35822266306321 0.0558217309377602 no 270 0.0871965207149516 116 3957 A H1 histamine antagonist.
SGTC_3255 9139072 49.47 µM 1.35780570842726 0.0558753898463288 no 271 0.0872626715581843 101 17646060
SGTC_477 mead ethanolamide 10 µM 1.35498622583505 0.0562393045959596 no 272 0.0877109727924168 57 16061185
SGTC_2519 cryptotanshinone 88.04 µM 1.35467506801586 0.056279580421731 no 273 0.0877605523533028 133 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_59 0330-0160 1.33 µM 1.34923440759415 0.0569874928863937 no 274 0.0886308431585882 112 4293482
SGTC_1306 1185-0270 9.02 µM 1.34808245214473 0.057138275345445 no 275 0.0888159323639437 121 1548076
SGTC_1276 0871-0068 94.2 µM 1.34786211537204 0.0571671515462077 no 276 0.0888513675042014 131 3414906
SGTC_2545 solidagenone 89.61 µM 1.3392111980061 0.0583100013854134 no 277 0.0902509639926191 78 6708572 An anti ulcer agent
SGTC_2167 5876490 200 µM 1.33628653563609 0.0587004044076333 no 278 0.0907278178459546 109 686534
SGTC_2522 biochanin a 4.94 µM 1.33583904048519 0.0587603195426164 no 279 0.0908009446728349 110 5280373 A possible chelator.
SGTC_624 k048-0052 28 µM 1.33397768444818 0.059010051718554 no 280 0.09110558504243 106 6835531
SGTC_2125 5246583 200 µM 1.33073343113219 0.0594473122876717 no 281 0.0916383693362844 132 835267
SGTC_1024 4507-0395 26 µM 1.32864757027391 0.0597297834288589 no 282 0.0919821349682968 120 4201836
SGTC_492 tmb-8 126 µM 1.3236906197528 0.0604052817184326 no 283 0.0928029075140073 101 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2582 agaric acid 100 µM 1.3188512970285 0.0610705031933861 no 284 0.0936094154831641 150 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2043 5101342 149 µM 1.31740154352065 0.0612708994351448 no 285 0.0938520319153417 126 678451
SGTC_1695 st026914 34.495 µM 1.31375992572306 0.0617765385297349 no 286 0.0944635037213019 116 3289191
SGTC_3153 9100258 49.47 µM 1.31244037330731 0.0619605604889071 no 287 0.094685796069011 120 25236848
SGTC_2113 5491891 107.031 µM 1.31240122422518 0.0619660266632025 no 288 0.0946923970235616 123 789979
SGTC_2645 abamectin 100 µM 1.31089326789683 0.0621768609857817 no 289 0.0949469128127678 129 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1089 terbinafine 2.25 µM 1.3102786447263 0.0622629546369331 no 290 0.095050794544049 114 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.30500289269465 0.0630057875361257 no 291 0.0959459313957761 140 688798
SGTC_58 0957-0393 9 µM 1.3023703657666 0.0633790234982129 no 292 0.0963949039359933 175 6997992
SGTC_2869 9037858 32.47 µM 1.30236369354177 0.0633799716586795 no 293 0.0963960438295515 116 27187042
SGTC_598 3937-0236 20.2 µM 1.29843263453063 0.0639405192493681 no 294 0.0970693555186275 130 1379313
SGTC_1307 1187-1599 12.2 µM 1.29469015802838 0.0644777510477833 no 295 0.0977135682338773 143 1538471
SGTC_2223 6903751 107.57 µM 1.29368070103416 0.0646232572704523 no 296 0.0978878670862367 116 5598863
SGTC_1208 2323-2347 50.3 µM 1.29105211296871 0.0650033467657345 no 297 0.0983428037999524 111 5412760
SGTC_3271 9137798 49.47 µM 1.28924043392806 0.0652663210710068 no 298 0.0986572560370395 102 6498326
SGTC_2018 5133068 143 µM 1.28315975963267 0.0661549985568454 no 299 0.099718055383138 126 785362
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.28248800202109 0.0662537466801089 no 300 0.0998357555583301 127 756377
SGTC_2252 omeprazole 400 µM 1.28063017251337 0.0665274413987642 no 301 0.100161798425164 93 4594 A proton pump inhibitor.
SGTC_417 st075190 100 µM 1.27914819656668 0.0667463923993228 no 302 0.100422437068122 138 222757
SGTC_2491 paeonol 100 µM 1.27808453422171 0.0669038840804158 no 303 0.100609810739629 111 11092 Increases levels of cortical cytochrome oxidase.
SGTC_937 3122-0005 46.7 µM 1.27568958782496 0.0672595452093884 no 304 0.101032635350875 127 759535
SGTC_779 1360-0071 233 µM 1.26990347675604 0.0681248415270197 no 305 0.102059507288829 141 7566
SGTC_1332 1480-0653 17.5 µM 1.26683474139894 0.0685872362885298 no 306 0.102607193451558 126 5749438
SGTC_1733 st037357 54.9 µM 1.26460354230862 0.0689249488326153 no 307 0.103006741307351 150 1272339 YGL099W LSG1
SGTC_2650 prasterone 100 µM 1.26294355835795 0.0691770331891923 no 308 0.103304732209139 98 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_264 promethazine 12.5 mM 1.26265847396423 0.0692203973531379 no 309 0.10335597185268 169 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2335 9018011 154.17 µM 1.26165477897448 0.0693732359955017 no 310 0.103536517795427 136 6458208
SGTC_3018 9082602 49.47 µM 1.25935240610524 0.0697248139886378 no 311 0.103951536045705 141 17332089
SGTC_1600 coumarin 106 71.1 µM 1.25930163273096 0.0697325826356468 no 312 0.103960701865124 137 100336 A hepatotoxic, DNA x-linker.
SGTC_3188 9110789 49.47 µM 1.25043909376005 0.0710988424916474 no 313 0.105569595601328 128 849217
SGTC_958 1222-0007 33 µM 1.25020793264599 0.0711347516985862 no 314 0.105611799894722 147 7312461
SGTC_2393 9031399 185.94 µM 1.24987015154873 0.0711872485892069 no 315 0.105673492292492 145 1526623 YDL150W RPC53
SGTC_452 diindolylmethane 8 µM 1.24610809816447 0.0717739475632049 no 316 0.106362356088455 119 3071 Inhibits expression of several cancer promoting factors.
SGTC_2646 retinol 96.75 µM 1.2435470947055 0.0721754575485155 no 317 0.10683314893518 144 445354 A vitamin A analog and teratogen.
SGTC_1403 3909-7815 62.9 µM 1.24222499474067 0.0723834068975087 no 318 0.10707678005572 126 6615483
SGTC_244 nsc-207895 1.295 µM 1.24162776983294 0.0724774930933781 no 319 0.107186965486142 83 42640
SGTC_1167 k781-0610 148 µM 1.24071583276223 0.0726213394294246 no 320 0.107355371658085 147 4525169
SGTC_1720 st037298 9.481 µM 1.24002341121018 0.0727307059783017 no 321 0.107483367531875 148 597396
SGTC_250 brefeldin a 552.239 µM 1.24000495860164 0.0727336222539052 no 322 0.107486780047102 114 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_454 lyso-paf C-16 6.67 µM 1.2395965642053 0.0727981883879781 no 323 0.107562326056883 136 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_858 0438-0351 2.77 µM 1.23687232668716 0.0732300067623246 no 324 0.108067242632496 133 2799119
SGTC_2344 7990960 76.95 µM 1.23254515924697 0.0739199299779325 no 325 0.10887275412665 165 140813
SGTC_1254 0550-0035 264 µM 1.23162574659043 0.0740671587991489 no 326 0.109044459360979 146 15121435
SGTC_1809 st050081 57.6 µM 1.22925219809403 0.0744482791816638 no 327 0.109488631827598 136 5036894
SGTC_870 0573-2213 57.6 µM 1.22835684523572 0.0745924341442435 no 328 0.109656520165532 128 3916321
SGTC_1457 k015-0032 57.3 µM 1.21793713106002 0.0762857462428847 no 329 0.111623932294883 136 4302660
SGTC_46 0329-0187a 2.197 µM 1.21758014189711 0.0763442747412259 no 330 0.111691782258248 138 46494817
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.21337843729076 0.0770357157250208 no 331 0.11249258323429 148 5282362
SGTC_1991 st073000 8.92 µM 1.21328853063266 0.0770505627837143 no 332 0.112509763208152 153 4301969 YIL048W NEO1
SGTC_2341 7987486 176.74 µM 1.2098278942122 0.0776237016954916 no 333 0.113172470125328 131 1258686
SGTC_1106 tegaserod maleate 11.7 µM 1.208945060108 0.0777704305970621 no 334 0.113341976572368 156 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_163 TUB2.036 7.546 µM 1.20880614971701 0.0777935369546207 no 335 0.11336866420896 182 15992207 YJR013W GPI14
SGTC_3073 9114972 49.47 µM 1.20813658430622 0.0779049855744101 no 336 0.113497364813809 116 41905075
SGTC_143 4032-1194 15.74 µM 1.20024123362168 0.0792283128846056 no 337 0.115022832796422 161 1806963
SGTC_3106 9121286 49.47 µM 1.19763375367906 0.0796690662809751 no 338 0.115529814810891 118 15943471
SGTC_32 0928-0142 34.1 µM 1.19670307461575 0.0798268313069889 no 339 0.115711154112659 144 2244242
SGTC_943 3253-1379 105 µM 1.19528850183045 0.080067076423661 no 340 0.115987165296464 159 668464
SGTC_1882 5615643 20 µM 1.18739999340463 0.0814168610263994 no 341 0.117534941303871 136 2253075
SGTC_1881 5652484 16 µM 1.18469899551763 0.0818829452996756 no 342 0.118068239886709 126 2255129
SGTC_181 1447-1644 8.07 µM 1.18419754856971 0.0819696958713406 no 343 0.118167436158562 160 534600
SGTC_2310 7668677 200 µM 1.18229365249422 0.0822997015416418 no 344 0.118544601658611 179 2197143
SGTC_1428 4049-0204 61.7 µM 1.17988619111386 0.0827184223118785 no 345 0.119022741365034 164 X1428
SGTC_1282 0886-0010 32.4 µM 1.17978192414398 0.0827365932298313 no 346 0.119043480280162 168 2836211 YNL267W PIK1
SGTC_2041 5107442 45.335 µM 1.17735937255886 0.0831596246610012 no 347 0.119526049230611 165 793005
SGTC_1553 gossypol 38.6 µM 1.17687226955651 0.0832448797362668 no 348 0.119623245880727 129 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1385 3091-4834 14.1 µM 1.17659718630279 0.0832930551358285 no 349 0.119678160683882 121 4072814
SGTC_2434 5670830 169.91 µM 1.17624605753218 0.0833545788539883 no 350 0.119748282262755 159 1549830
SGTC_332 4112-0506 40.9 µM 1.17618717107823 0.0833649001038037 no 351 0.119760044918965 176 2790355
SGTC_1497 4476-2978 41.3 µM 1.17483158299114 0.0836027647980522 no 352 0.120031050929588 140 1528379
SGTC_864 0469-0573 172 µM 1.17326126991005 0.0838789443354565 no 353 0.120345524266455 154 689425
SGTC_529 4076-0302 30.3 µM 1.17148397379504 0.0841923530882205 no 354 0.120702147974114 144 5816522
SGTC_33 0986-0033 35.816 µM 1.17122900582411 0.0842373861907939 no 355 0.120753369577684 112 2848082
SGTC_3166 9102297 49.47 µM 1.16907978302662 0.0846177062090835 no 356 0.121185744224623 147 25237072
SGTC_301 4119-0100 24.5 µM 1.1675579187892 0.0848877886073765 no 357 0.121492566406499 144 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1510 1123-0200 71.5 µM 1.16699087109923 0.0849885865928122 no 358 0.121607028089945 173 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_944 3370-0224 231 µM 1.1662160647909 0.0851264606075869 no 359 0.121763549487072 115 4580514
SGTC_1450 4112-4260 37.6 µM 1.16173193624829 0.0859276889965591 no 360 0.122672184491147 161 1633175
SGTC_623 k072-0108 16.9 µM 1.16105670382725 0.0860488274643485 no 361 0.122809420213607 165 5382803
SGTC_2649 anisomycin 9.56 µM 1.16089782490619 0.0860773493200655 no 362 0.122841726756379 147 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1565 sinapyl alcohol 95.1 µM 1.15977148259544 0.0862797525057667 no 363 0.12307092882249 158 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1479 0549-0158 134 µM 1.1565843030407 0.0868544156319254 no 364 0.123721119225788 147 5440202
SGTC_839 0122-0028 230 µM 1.15636526908475 0.086894013228305 no 365 0.123765890703117 201 759448
SGTC_1610 st001799 48.1 µM 1.1554382393522 0.0870617537086729 no 366 0.123955505131336 133 621897
SGTC_2742 clothiapine 36.27 µM 1.15476948088492 0.087182911629664 no 367 0.124092418991297 102 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3183 9108214 49.47 µM 1.1525408323409 0.0875875812995604 no 368 0.124549450379531 93 4974831
SGTC_2551 apiole 73.87 µM 1.15137437541898 0.0877999401557852 no 369 0.124789125534658 131 10659 A possible DNA adduct former.
SGTC_1467 k284-1082 293 µM 1.15072495764461 0.0879183359609071 no 370 0.124922702794365 164 3334705
SGTC_2532 xanthone 78.9 µM 1.14957978231601 0.0881274036988764 no 371 0.125158494609637 125 7020 An insecticide.
SGTC_887 0885-0007 9.62 µM 1.14497192494086 0.0889723790619774 no 372 0.126110393721965 163 5719458
SGTC_871 0574-0004 149 µM 1.14126354530778 0.0896567791605314 no 373 0.126880133777765 169 9551173
SGTC_217 ketoconazole 989 nM 1.13978230688627 0.0899312404484028 no 374 0.127188503361243 158 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1562 morin hydrate 59.1 µM 1.13297185016954 0.0912012006733347 no 375 0.128613037415907 147 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_75 0159-0059 199.013 µM 1.13258575679728 0.0912735926215865 no 376 0.12869412637375 177 5377270
SGTC_2525 harmine 47.85 µM 1.13221632865888 0.0913428997394586 no 377 0.128771748432243 143 5280953 A monoamine oxidase inhibitor
SGTC_3086 9117350 49.47 µM 1.13012083632383 0.0917367661364662 no 378 0.129212655510558 119 2679265
SGTC_1238 0333-0287 48.8 µM 1.12867964120866 0.0920083808699491 no 379 0.129516500306214 159 7226
SGTC_1368 1852-0141 284 µM 1.12389797319987 0.0929138229435996 no 380 0.130528155631757 159 2838987
SGTC_548 1436-0017 110 µM 1.1223870865924 0.0932012849602323 no 381 0.130848946315606 148 9677137
SGTC_2638 epoxomicin 18 µM 1.12039772781401 0.0935807829493777 no 382 0.131272156390902 138 9915668 A protesome inhibitor.
SGTC_3032 9089427 49.47 µM 1.12018078947855 0.0936222358720721 no 383 0.131318364282649 136 17173707
SGTC_995 3931-2021 34.6 µM 1.1147903698273 0.0946566042160102 no 384 0.132470132102718 158 730143
SGTC_2771 fluoxetine 41.05 µM 1.11375596693757 0.0948560555554344 no 385 0.132691946004877 138 3386 A selective serotonin reuptake inhibitor.
SGTC_1507 4075-3230 155 µM 1.1134883108649 0.0949077148167113 no 386 0.132749382917794 146 659771
SGTC_39 0986-0283 58.349 µM 1.11143660027308 0.095304396106799 no 387 0.133190232754076 144 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1975 st070967 30.8 µM 1.11043886060293 0.0954977413905344 no 388 0.133404980174068 206 261391
SGTC_2380 9035439 200 µM 1.10950610206725 0.0956787553710238 no 389 0.133605956754034 148 6462575
SGTC_621 3584-0052 32.1 µM 1.10707531085869 0.096151668106456 no 390 0.134130684454132 160 2273927
SGTC_512 prima-1 270 µM 1.10504941764163 0.0965471186265873 no 391 0.13456908829878 136 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2324 6149169 200 µM 1.10218654785579 0.0971079807738233 no 392 0.135190289507873 165 2888231
SGTC_1627 st003713 25.6 µM 1.10030038790401 0.0974788010498257 no 393 0.135600631598921 159 16195070 YER133W GLC7
SGTC_1395 3486-0190 4.35 µM 1.09990431449391 0.0975568011131443 no 394 0.135686907339227 167 6748079
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.09703609249228 0.0981230159546433 no 395 0.136312807423638 142 1241132 A phosphatase inhibitor.
SGTC_2748 diazoxide 86.69 µM 1.09682497195671 0.0981647881305275 no 396 0.136358955828674 104 3019 A potassium channel activatior.
SGTC_184 1494-0393 24.714 µM 1.09572371019146 0.0983828943133745 no 397 0.136599851664189 192 3090647
SGTC_259 usnic acid 108.925 µM 1.09208828836965 0.0991054129689091 no 398 0.137397148328043 188 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2109 5483026 200 µM 1.08986690576424 0.0995488055258038 no 399 0.137885888265858 214 759335
SGTC_1839 st053978 48 µM 1.08768744620099 0.0999852373930097 no 400 0.138366555808844 147 3788398
SGTC_300 r073-0011 5.04 µM 1.08723407105608 0.100076200038947 no 401 0.138466688471645 160 2735780
SGTC_1673 st016611 27.3 µM 1.08628712704173 0.100266384440076 no 402 0.138675990254213 187 5226799
SGTC_1660 st012960 28.1 µM 1.08546635252162 0.100431442244859 no 403 0.138857579229583 158 24207266
SGTC_3028 9087778 49.47 µM 1.08429493534995 0.100667357591107 no 404 0.139117025083074 166 17217395
SGTC_1915 st067105 30.6 µM 1.0828621886166 0.100956452108195 no 405 0.139434798595877 179 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2920 7982904 15.77 µM 1.08231726794056 0.101066562976641 no 406 0.139555787815132 171 6456808
SGTC_2761 levamisole 97.89 µM 1.08033053920958 0.10146875801751 no 407 0.139997507513243 132 26879 An alkaline phosphatase inhibitor.
SGTC_1487 3970-0795 2.82 µM 1.07957387555977 0.101622243791123 no 408 0.1401659900189 165 3765103
SGTC_2329 6138490 200 µM 1.07813404322222 0.101914774005492 no 409 0.140486970559992 165 720019
SGTC_735 3076-0345 636 µM 1.07071715758544 0.103431372588447 no 410 0.14214831284132 164 2888990
SGTC_1505 k297-0037 20.6 µM 1.06156184381546 0.105325949914124 no 411 0.144217321693388 155 4089396
SGTC_650 1328-0195 38 µM 1.05774261273071 0.106123668931355 no 412 0.145086401113524 181 2780821
SGTC_559 1550-0661 158 µM 1.05674368655412 0.106333031905397 no 413 0.145314290601951 162 5830875
SGTC_467 ro 31-8220 72.8 µM 1.05163216851122 0.107409013830857 no 414 0.146484171477399 172 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2123 5259487 200 µM 1.04628604689683 0.108542753384771 no 415 0.14771449276852 167 2173474
SGTC_2251 lansoprazole 556 µM 1.04509050221888 0.108797463321147 no 416 0.147990571655302 166 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1203 3992-3522 103 µM 1.04357026517909 0.109121969065133 no 417 0.148342128018637 186 5322312
SGTC_1832 st054113 55 µM 1.04355290727702 0.109125678248497 no 418 0.148346145274018 151 1251267
SGTC_2045 5106652 78.05 µM 1.04320317926304 0.10920043039283 no 419 0.14842710067081 151 673349
SGTC_2648 atorvastatin 78.68 µM 1.04206846430368 0.1094432218512 no 420 0.148689969064911 164 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.04108987337388 0.109652919088094 no 421 0.148916919489097 140 6708630 An antioxidant.
SGTC_2377 9073351 62.6 µM 1.04035529546132 0.109810517455093 no 422 0.149087431507846 184 7337946 YHR072W ERG7
SGTC_336 4111-0029 111 µM 1.03996290187337 0.109894769242216 no 423 0.149178568280924 156 3131175
SGTC_739 1486-1183 203 µM 1.03745826099197 0.11043364001404 no 424 0.149761169125364 165 4346692
SGTC_2056 5235370 200 µM 1.03534333754023 0.110890136615572 no 425 0.150254298750131 161 5511916
SGTC_3084 9116877 49.47 µM 1.03355531561424 0.111277126270746 no 426 0.15067204909375 150 27241325
SGTC_2081 5214970 32.255 µM 1.03254389690226 0.111496459848281 no 427 0.15090869738002 143 2063512
SGTC_1677 st019204 53.9 µM 1.03091671720826 0.111849974648998 no 428 0.151289938222067 160 3945625
SGTC_2138 5575593 77.673 µM 1.02995473515992 0.112059347830308 no 429 0.151515627316998 159 762213
SGTC_1521 st012942 49.4 µM 1.02805197967659 0.1124743030586 no 430 0.151962688692167 168 24207259
SGTC_2625 euphol 100 µM 1.02579586353294 0.112967740584277 no 431 0.152493908136162 190 6708538 A triterpene alcohol.
SGTC_618 k072-0232 33.2 µM 1.02490501129897 0.113163004694874 no 432 0.15270400491571 187 5872756 YGL099W LSG1
SGTC_942 3253-1115 227 µM 1.01835814113119 0.114605390275712 no 433 0.154253893588892 191 46497897
SGTC_2084 5306078 60.6385 µM 1.01749100303543 0.114797412269353 no 434 0.154459955053219 181 679340
SGTC_1009 4106-0057 9.87 µM 1.01637033112633 0.115045916557988 no 435 0.154726534198787 202 2928005
SGTC_832 4083-0019 164 µM 1.01503648618592 0.115342189385956 no 436 0.15504421774357 205 1990758
SGTC_1179 1021-1431 9.29 µM 1.01417610991149 0.115533583117734 no 437 0.155249363004816 205 2840958
SGTC_287 k060-0039 29.6 µM 1.01239065062873 0.115931484577947 no 438 0.155675653415133 177 5861974
SGTC_2784 7567673 72.73 µM 1.01121257206168 0.116194559424317 no 439 0.155957349922132 180 3471247
SGTC_2103 5378138 10 µM 1.00998501304127 0.116469134095996 no 440 0.156251235190841 181 244142
SGTC_2651 TUB2.036 5 µM 1.00970535139623 0.116531751823065 no 441 0.156318238920389 191 15992207 YFL037W TUB2
SGTC_2149 5554786 194.827 µM 1.00940481790849 0.116599069478696 no 442 0.156390264398582 168 745063 YPR165W RHO1
SGTC_1200 1643-0193 18.4 µM 1.00742739716892 0.117042687293022 no 443 0.156864715502091 200 5403974
SGTC_1292 0kpi-0043 232 µM 1.00689301635095 0.117162776166846 no 444 0.156993094184548 183 3333905
SGTC_3312 9133330 71.43 µM 1.00598426235955 0.117367196543848 no 445 0.157211570261492 193 17617324
SGTC_1815 st051655 58.2 µM 1.0041206886263 0.117787189371964 no 446 0.15766022225372 194 5984156
SGTC_2390 9097792 176.6 µM 1.00373608664119 0.117873999191299 no 447 0.157752919091329 168 4497149
SGTC_319 1348-1596 45.5 µM 1.00259492537807 0.11813184096456 no 448 0.158028172628337 191 5380505
SGTC_446 go6976 132 µM 0.997892481711212 0.119198550875202 no 449 0.159165749030953 176 3501 A protein kinase C inhibitor.
SGTC_728 3030-5151 22.5 µM 0.996656777046492 0.119479984706346 no 450 0.159465568279523 176 3125388
SGTC_2546 rhodinyl acetate 100 µM 0.99431614103568 0.120014352788569 no 451 0.160034489965738 190 6708682
SGTC_895 0964-0006 13.7 µM 0.993194048030054 0.120271123506023 no 452 0.160307699178157 220 6738897
SGTC_1171 0368-0077 21.4 µM 0.991253409388872 0.120716116622348 no 453 0.16078092840518 189 3239779
SGTC_1103 duloxetine 36.1 µM 0.99007063171556 0.120987898174635 no 454 0.161069798404596 193 60835 A selective serotonin reuptake inhibitor.
SGTC_2879 9041815 71.43 µM 0.986717127940684 0.12176081432873 no 455 0.161890665492894 146 4942971
SGTC_2424 5537928 59.2 µM 0.986067437631865 0.121910955352074 no 456 0.162050010610337 196 5382802
SGTC_2135 5326629 150.42 µM 0.984056813598246 0.1223764269255 no 457 0.162543789676912 171 5020077
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.980835174871135 0.12312485360865 no 458 0.16333701459953 161 4000243
SGTC_257 daunorubicin 18.5 µM 0.980004165348145 0.123318426844349 no 459 0.163542031282337 184 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_216 k038-0035 28.382 µM 0.979228606637355 0.123499275779596 no 460 0.163733518492877 214 4444231 YPR107C YTH1
SGTC_1261 0712-0010 12.7 µM 0.978792758932192 0.123600990575896 no 461 0.163841194134543 192 2840123
SGTC_665 3914-0008 307 µM 0.973539155576274 0.124831653007859 no 462 0.165142704772792 189 1069549
SGTC_1969 st069479 40.1 µM 0.971641178912459 0.125278354427731 no 463 0.165614544480654 191 3895485
SGTC_2092 5303694 80.6725 µM 0.967996702471462 0.126139232321364 no 464 0.166523008281042 194 1963699
SGTC_2770 toltrazuril 17.5 µM 0.96714642346836 0.126340672360446 no 465 0.166735420461542 182 68591 Kills coccidiodes.
SGTC_938 3126-1755 342 µM 0.96667462925506 0.126452542020428 no 466 0.166853356966367 183 1777771
SGTC_716 1683-5115 658 µM 0.966558895102135 0.126479994904647 no 467 0.166882295766508 194 723597
SGTC_3291 9121177 71.43 µM 0.966083782304872 0.126592738219024 no 468 0.167001129491271 179 17015612
SGTC_1047 2043-3044 82 µM 0.962338803600044 0.127483864691515 no 469 0.167939721535045 217 669592
SGTC_1382 3002-2117 298 µM 0.961176017333104 0.127761437747698 no 470 0.168231836418842 206 1497314
SGTC_2257 7960413 200 µM 0.958619044836426 0.128373298885539 no 471 0.168875347359979 198 2974689 YIL048W NEO1
SGTC_1061 3448-9325 110 µM 0.953155056171274 0.129687593821687 no 472 0.170255757117191 216 723482
SGTC_2993 9054257 71.4286 µM 0.95181990940082 0.130010158742322 no 473 0.170594161562086 210 6470217 YGL055W OLE1
SGTC_745 0469-0705 296 µM 0.951641776074654 0.130053236833798 no 474 0.17063934352522 228 3486736
SGTC_2058 5236698 133 µM 0.947126608702059 0.131148442267943 no 475 0.17178713365468 182 766665
SGTC_816 0325-0417 81.3 µM 0.945517933365858 0.131540179689205 no 476 0.172197259840226 198 68101
SGTC_2708 st078559 56 µM 0.944892945912268 0.131692591466138 no 477 0.172356766612191 175 17250902
SGTC_1997 st073024 93.8 µM 0.943272449890029 0.13208833913422 no 478 0.172770781921682 193 686268
SGTC_1191 1487-1166 10.6 µM 0.94272438644634 0.132222369235264 no 479 0.172910948212665 191 3955771
SGTC_760 0568-0725 82.9 µM 0.940369194494808 0.132799403484962 no 480 0.173514108979255 213 3916171
SGTC_1554 st069299 38.7 µM 0.935581012298402 0.133977873511875 no 481 0.174744477265601 184 24207999
SGTC_1718 roemerine 11.9335 µM 0.934951449238795 0.134133354810628 no 482 0.174906660378933 206 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2490 carminic acid 95.39 µM 0.933641070216929 0.13445737255612 no 483 0.175244536192081 192 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1079 idarubicin 2.36 µM 0.933109573302983 0.134588948987748 no 484 0.175381698384396 225 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_669 0108-0021 26.2 µM 0.930891109936253 0.13513910196785 no 485 0.17595494681242 235 17201
SGTC_1071 trifluoperazine 6.31 µM 0.93054704125416 0.135224564904314 no 486 0.176043959931298 212 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1556 plumbagin 1.48 µM 0.929365431491316 0.13551834607043 no 487 0.176349868160292 207 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_185 k048-0037 25.491 µM 0.927826415760969 0.135901643667104 no 488 0.176748809590019 186 6827589
SGTC_2819 7996655 46.38 µM 0.925722997109968 0.136426707462684 no 489 0.177294976700278 177 6456960
SGTC_2001 4023502 57.655 µM 0.924032499416382 0.136849700815657 no 490 0.17773469763339 178 108941 YCR052W RSC6
SGTC_2481 5478948 45.16 µM 0.922590990178562 0.137211100115311 no 491 0.178110196363945 194 77792
SGTC_1531 st059297 52.4 µM 0.919241821173727 0.138053281904411 no 492 0.178984550443063 209 7566702
SGTC_3232 9132874 49.47 µM 0.918305456898606 0.138289369257039 no 493 0.179229485608534 195 3784940
SGTC_2099 5377090 177.372 µM 0.91642604298495 0.138764059744151 no 494 0.179721740543631 207 2243829
SGTC_148 3253-0744 288.01 µM 0.91531216060641 0.139045920297285 no 495 0.180013888444181 207 6893655
SGTC_324 1315-0088 19.6 µM 0.914962268995762 0.139134538433027 no 496 0.180105719159176 218 6787421
SGTC_2745 rifampicin 24.3 µM 0.909557550429234 0.140508291744974 no 497 0.181527947039291 149 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2003 4023581 200 µM 0.906679254249699 0.141243632714767 no 498 0.182288218598097 178 16641307
SGTC_1758 st042942 75.2445 µM 0.906474648771949 0.141296004025211 no 499 0.182342338620005 214 669317
SGTC_777 1315-0167 517 µM 0.904779524365868 0.141730398411079 no 500 0.182791100605621 215 4221767
SGTC_400 oxethazaine 37.5 µM 0.904549048233369 0.14178953024943 no 501 0.182852169341127 201 4621 A local anesthetic.
SGTC_2912 7964298 10.93 µM 0.904171401240268 0.141886456919941 no 502 0.182952261128254 216 2975850
SGTC_1168 k815-0004 80.5 µM 0.903769441370021 0.141989672999967 no 503 0.18305883436978 225 642433
SGTC_3224 9130643 49.47 µM 0.903585588607789 0.142036900027362 no 504 0.183107592900585 219 17644395
SGTC_953 1188-0045 9.7 µM 0.902905936626834 0.142211577374447 no 505 0.183287909805159 212 6144426
SGTC_2327 6189656 200 µM 0.902802346438119 0.142238213848935 no 506 0.183315402801346 206 5349088
SGTC_50 0929-0078 56.389 µM 0.901840397525314 0.142485724059741 no 507 0.18357082832498 189 1377751
SGTC_2664 lyso-paf C-16 73.48 µM 0.896423105164966 0.143885035342868 no 508 0.185013415867381 231 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1422 4031-0024 15.5 µM 0.891961709543719 0.145044372568281 no 509 0.186206728192021 231 782427
SGTC_836 0330-0104 1.35 µM 0.890530658121622 0.145417573463363 no 510 0.186590506968032 199 46494820
SGTC_3 0833-0587 95.581 µM 0.887712505761122 0.146154400395802 no 511 0.187347708590181 208 5382644
SGTC_635 k038-0028 24.7 µM 0.887503946887504 0.146209029151619 no 512 0.187403821092955 211 4035102
SGTC_2 0422-0095 29 µM 0.884091744655907 0.147104750097004 no 513 0.188323344617772 198 6790840
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.883193790186595 0.147341078064683 no 514 0.188565788083921 207 6710655
SGTC_2919 7978188 46.38 µM 0.882440670833383 0.147539483718577 no 515 0.188769275069352 197 2980291
SGTC_462 ag-879 158 µM 0.880788252071431 0.147975432361017 no 516 0.189216219746397 237 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_912 3474-0017 2.18 µM 0.880196204676506 0.148131838597263 no 517 0.189376514586817 207 3360550
SGTC_2353 9059630 146.67 µM 0.878643361449181 0.148542591920854 no 518 0.189797338604644 212 4779114
SGTC_3100 9120536 49.47 µM 0.878610052196685 0.148551411117163 no 519 0.189806371782549 195 16421196
SGTC_2278 7948257 134.34 µM 0.876287229464095 0.149167281819071 no 520 0.190436952883422 211 1247028
SGTC_558 k064-0027 21.3 µM 0.875365983279649 0.149412011623103 no 521 0.19068740121501 216 5088526
SGTC_3056 9094900 49.47 µM 0.874687997994136 0.149592290081929 no 522 0.190871846143814 229 25236784
SGTC_2848 9016370 25.97 µM 0.873950641813579 0.149788520160664 no 523 0.191072567043565 200 7894410
SGTC_718 1130-0073 349 µM 0.873096476876551 0.150016050719909 no 524 0.191305247031004 199 6740020
SGTC_556 4058-0063 51.5 µM 0.872831725549927 0.150086621349284 no 525 0.191377402227088 212 6615692
SGTC_1547 harmine 94.2 µM 0.871624958019843 0.150408570850882 no 526 0.191706505273696 207 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1840 st055363 71 µM 0.87143027218505 0.150460553509462 no 527 0.191759631378864 222 676033
SGTC_213 1246-0773 967 nM 0.870053448961736 0.150828517792675 no 528 0.19213559781213 202 6251622
SGTC_2446 5162541 200 µM 0.869946149867698 0.150857219262026 no 529 0.192164916697126 223 1549321
SGTC_1360 1598-0022 39.8 µM 0.86994609794197 0.150857233152536 no 530 0.192164930886207 230 761525
SGTC_2221 6807166 181.081 µM 0.869248834919988 0.151043832848681 no 531 0.192355520841158 192 674925
SGTC_356 1634-0012 32.5 µM 0.869088441294643 0.151086778688799 no 532 0.192399379201492 236 735457
SGTC_1175 0741-0056 27.6 µM 0.867965048104633 0.151387798066804 no 533 0.192706733490754 222 765927
SGTC_2097 5376186 200 µM 0.866395260728782 0.151809098815255 no 534 0.19313672101333 215 742755
SGTC_1500 4488-1866 171 µM 0.863329607870586 0.152634105370129 no 535 0.193978134906485 230 2900003
SGTC_1635 st007035 42.4 µM 0.863086473050975 0.152699663136192 no 536 0.194044962328687 221 3716403
SGTC_2047 4141938 200 µM 0.861216904134887 0.153204389107986 no 537 0.194559295793567 242 3807862
SGTC_1090 efavirenz 20.7 µM 0.858012633953126 0.15407201162421 no 538 0.195442743596867 213 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2178 5812956 200 µM 0.857505028107113 0.154209754098594 no 539 0.195582918592463 228 5403383
SGTC_360 0957-0399 1.01 µM 0.856851262793998 0.154387277952274 no 540 0.195763545336459 215 6752301 YPR165W RHO1
SGTC_1811 st050069 61.5 µM 0.856823190010967 0.154394903878166 no 541 0.19577130374309 221 3877702
SGTC_1211 1056-0033 32.3 µM 0.852930046956279 0.155454882037695 no 542 0.196849048958253 214 6741922
SGTC_2301 7769476 200 µM 0.851930146594171 0.155727896002523 no 543 0.197126431773497 210 977820
SGTC_1005 4092-0690 4.4 µM 0.85032209712744 0.156167622445041 no 544 0.197573017246817 228 1529343
SGTC_2616 abietic acid 100 µM 0.849835718476773 0.156300785282574 no 545 0.197708214091671 234 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1028 k015-0029 4.8 µM 0.849639243934456 0.156354598130101 no 546 0.197762843231678 222 4588309
SGTC_2146 5545642 200 µM 0.849546229667036 0.156380078269242 no 547 0.197788708742479 209 825326
SGTC_2520 obtusaquinone 4.71 µM 0.849242583705861 0.156463277460871 no 548 0.19787316117592 224 5967872
SGTC_3155 9099265 49.47 µM 0.847906091803864 0.156829823545584 no 549 0.198245135830485 213 25236499
SGTC_487 nimodipine 119 µM 0.847673013099358 0.156893805496334 no 550 0.198310049880515 205 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1195 1502-0147 41.1 µM 0.846736700314314 0.15715100381921 no 551 0.198570948790591 201 817940
SGTC_922 1866-0035 480 µM 0.846460120276676 0.157227031365669 no 552 0.198648056038123 238 3156169
SGTC_1156 4092-0367 4.88 µM 0.845384346840097 0.157522974667781 no 553 0.198948140627114 240 1357585
SGTC_2518 prenyletin 46.28 µM 0.84513574996485 0.15759141524803 no 554 0.199017525009252 199 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_228 caffeine 993.056 µM 0.841369780203138 0.158630604444952 no 555 0.200070404817124 179 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1509 1326-1131 80 µM 0.840644179331708 0.158831343301836 no 556 0.20027365043545 208 768313
SGTC_2476 5806916 10.51 µM 0.840572834248637 0.158851090040949 no 557 0.200293641363329 225 2870194
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.839274533430328 0.159210712008963 no 558 0.200657635287053 232 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2692 st077426 47.7 µM 0.834998878446971 0.160398810923186 no 559 0.201859169931138 230 25238571
SGTC_1239 0337-0584 35.4 µM 0.834762731590569 0.160464598693573 no 560 0.201925656660626 234 914301 YML130C ERO1
SGTC_1273 0849-0096 14.1 µM 0.833769193912807 0.160741579834387 no 561 0.202205529006476 236 5286025
SGTC_212 3807-4682 38.772 µM 0.833137861499113 0.160917746529231 no 562 0.202383491283093 225 3125501 YBL034C STU1
SGTC_1251 0490-5699 265 µM 0.833013901969506 0.160952350933683 no 563 0.202418444443546 236 3883818
SGTC_2469 5655019 90.81 µM 0.831193204520821 0.161461174359245 no 564 0.202932246549204 228 2788239
SGTC_1019 4262-0212 3.4 µM 0.823301038992492 0.163678881225827 no 565 0.205168411469634 240 4677213
SGTC_2130 NSC 7 2.4545 µM 0.822996411304058 0.163764876456729 no 566 0.205255017105349 217 21448
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.822681880169349 0.163853698159077 no 567 0.205344461076117 226 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3238 9133470 49.47 µM 0.82125516604863 0.164256986112031 no 568 0.205750469770592 194 3534688
SGTC_2193 5925765 200 µM 0.818364755518008 0.165075986899825 no 569 0.206574470149611 217 877370
SGTC_99 0109-0120 622.8 µM 0.818343377716598 0.165082054153949 no 570 0.206580571821685 244 759414
SGTC_1498 4478-3555 97.6 µM 0.81711572532561 0.165430717525653 no 571 0.206931148564772 218 3437919
SGTC_3354 9151612 71.43 µM 0.816536413990712 0.165595412031297 no 572 0.207096702840746 209 27261949
SGTC_1539 benzyladenosine 56 µM 0.814855406323427 0.166073911795678 no 573 0.207577540743605 219 92208 A nucleotide analog.
SGTC_893 0958-0369 48.9 µM 0.813577238575509 0.166438340215853 no 574 0.207943590846964 241 6819948
SGTC_2693 st077581 40.7 µM 0.813157113377524 0.166558238060703 no 575 0.208063992244485 243 25238761
SGTC_7 0192-1582 4.227 µM 0.812702363558264 0.16668808010289 no 576 0.208194362888815 263 252616
SGTC_2308 7584454 197.62 µM 0.810109020828302 0.167429789958159 no 577 0.208938760059736 228 893577
SGTC_2008 4012253 172 µM 0.810102745990296 0.167431587170362 no 578 0.208940563098357 217 603940
SGTC_1127 asiatic acid 681.4 nM 0.808936506422342 0.167765832350261 no 579 0.209275834461056 243 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2465 5809242 33.21 µM 0.80736879785152 0.168215815338658 no 580 0.209727018985027 258 2731748
SGTC_65 0798-0905 34.986 µM 0.80511116155593 0.168865192742571 no 581 0.210377767718797 234 3602145
SGTC_2876 9059903 25.97 µM 0.804836918875313 0.168944184362626 no 582 0.210456897022727 220 6916095
SGTC_69 0096-0274 206.684 µM 0.803819237494668 0.169237520132302 no 583 0.210750688949699 276 6741392
SGTC_2995 9067767 71.4286 µM 0.803072751608036 0.169452894461503 no 584 0.210966342985225 203 11673567
SGTC_1080 nisoldipine 24.4 µM 0.801062095623366 0.17003387859511 no 585 0.211547849188166 230 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1060 3448-7350 82 µM 0.800985659594819 0.170055990140639 no 586 0.211569973918518 232 570178
SGTC_2531 methyl deoxycholate 70.07 µM 0.800646827349956 0.170154030304961 no 587 0.211668066649831 244 16667744 Haematoxylin.
SGTC_1115 galangin 695.678 nM 0.800467913446699 0.170205813152294 no 588 0.211719873382619 252 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_662 k832-1615 104 µM 0.800429955846774 0.17021680047544 no 589 0.211730865429094 240 5878478
SGTC_1817 st052116 64.4 µM 0.798585860215786 0.170751145347824 no 590 0.212265294613124 222 4361398
SGTC_2311 7694451 200 µM 0.798207512363878 0.170860907950274 no 591 0.212375039322636 255 2163142
SGTC_391 gliotoxin 8.33 µM 0.795029470775653 0.171784672272879 no 592 0.213298179630467 241 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2696 st077691 74.316 µM 0.793940579568092 0.172101913624409 no 593 0.213615012192127 246 757133
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.791393106273845 0.172845563032215 no 594 0.2143573157642 260 688801
SGTC_1873 rapamycin 2 nM 0.787635894065445 0.173946086513111 no 595 0.215454856432545 227 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2796 7949634 45.45 µM 0.786599834284239 0.174250340359103 no 596 0.215758078159114 255 2971588
SGTC_3068 9116768 49.47 µM 0.784791911474979 0.174782072270224 no 597 0.216287791640068 242 41904888
SGTC_105 0111-0055 734.78 µM 0.784379391161657 0.174903543638893 no 598 0.216408763697779 222 5179370
SGTC_1620 st003704 16.5 µM 0.784115838845217 0.174981177701706 no 599 0.216486071214944 240 2834414
SGTC_1113 artemisinin 1.17947 µM 0.783251220543338 0.175236020027606 no 600 0.216739800948006 261 2240 An anti-malaria and mitochondrial poison.
SGTC_343 4130-2827 29.8 µM 0.782309923950264 0.175513730399068 no 601 0.217016228016527 228 1118244
SGTC_2890 9046729 58.44 µM 0.781412375468108 0.175778793431486 no 602 0.217279997397131 244 903329
SGTC_80 0159-0065 512.242 µM 0.780099530394277 0.176166957847867 no 603 0.217666146427134 231 1548079
SGTC_1129 3453-1384 223 µM 0.779681334858241 0.176290718143327 no 604 0.217789233994663 255 1084452
SGTC_1889 st059080 5.18 µM 0.777772420582947 0.176856338486061 no 605 0.218351594745383 229 176925 Isolated from Daphnopsis sellowiana.
SGTC_1888 azatryptophan 97.5 µM 0.777689978508176 0.176880792274021 no 606 0.218375900775683 204 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1420 4'-methoxyflavone 42 µM 0.776475709074277 0.177241213721133 no 607 0.218734078913875 242 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3241 9133421 49.47 µM 0.776242183504276 0.177310582304578 no 608 0.218803001672529 276 17018221
SGTC_2946 9065502 71.43 µM 0.772035779983189 0.178563025528411 no 609 0.220046618091536 201 16489101
SGTC_2472 5377652 49.4 µM 0.771674452069824 0.17867086900716 no 610 0.220153632897441 254 1610903
SGTC_422 cantharidin 155 µM 0.768438124791242 0.179638625094812 no 611 0.221113468819496 258 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1924 st058459 75.1 µM 0.7678333704631 0.179819828842405 no 612 0.221293093129581 247 688683
SGTC_1088 bifonazole 369 nM 0.7677585939159 0.17984224226199 no 613 0.22131530907798 241 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_182 3448-4371 550.524 µM 0.765022944178878 0.18066342830104 no 614 0.222128941084332 219 3491403
SGTC_659 k018-0002 107 µM 0.764869926853069 0.180709430298468 no 615 0.222174501583616 249 6797879 YHR007C ERG11
SGTC_1035 k081-0041 55.2 µM 0.764511323112013 0.180817267045957 no 616 0.222281295779791 247 731709
SGTC_1480 1070-0044 41.2 µM 0.764334154183238 0.180870558901028 no 617 0.222334068483501 244 3124987
SGTC_1003 4049-0218 100 µM 0.762263916976978 0.18149400915093 no 618 0.222951252458113 252 295161
SGTC_198 3454-2873 16.191 µM 0.761946585541625 0.181589692014284 no 619 0.223045942233236 258 710957
SGTC_615 k087-0205 167 µM 0.761918945360938 0.181598027670756 no 620 0.223054190979603 263 9642773
SGTC_491 tetrandrine 80.3 µM 0.76080959723489 0.181932779753336 no 621 0.223385400615639 253 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2397 5161689 200 µM 0.760277818621979 0.182093383703976 no 622 0.223544268883942 263 2259942
SGTC_23 0213-0011 39.996 µM 0.75850948194859 0.182628081157801 no 623 0.22407301939917 255 627608
SGTC_2187 6125751 200 µM 0.758353233915718 0.182675373457394 no 624 0.224119773272437 254 874498
SGTC_2974 9094440 9.66 µM 0.757349084057682 0.182979486492473 no 625 0.22442037577708 241 25236134
SGTC_104 0074-0074 590.992 µM 0.756712846573885 0.183172338372659 no 626 0.224610958323301 227 3943124
SGTC_827 3253-0474 693 µM 0.755957864295751 0.18340134776057 no 627 0.224837229493466 251 5402065
SGTC_2989 9073649 71.4286 µM 0.753935699901451 0.184015611348459 no 628 0.225443916349919 268 21367202
SGTC_997 3996-0078 137 µM 0.751995053205431 0.184606315694327 no 629 0.226027016825986 245 735687
SGTC_653 0203-0016 55.2 µM 0.747571123776265 0.185957296324877 no 630 0.227359443813769 259 295302
SGTC_131 0141-0277 33.849 µM 0.747417379354784 0.18600435679194 no 631 0.227405828958962 254 1547771
SGTC_585 0kpi-0023 191 µM 0.74367072099586 0.18715347338103 no 632 0.228537853410738 220 64601
SGTC_1728 st035614 33.7865 µM 0.739290374239095 0.1885024987864 no 633 0.229865346535567 248 15945546
SGTC_110 0850-0284 111.64 µM 0.738895202564085 0.188624494893979 no 634 0.229985317851422 236 3906265
SGTC_3107 9121808 49.47 µM 0.738071505349847 0.188878940430629 no 635 0.230235499094082 224 662681
SGTC_2808 7946468 45.46 µM 0.736587555114861 0.189337875915765 no 636 0.230686602635782 271 2970879
SGTC_502 l-744,832 89.3 µM 0.736484403713188 0.189369802640998 no 637 0.230717977801216 271 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2644 guaiazulene 100 µM 0.735858404011261 0.189563628908177 no 638 0.230908436846549 238 3515 A coloring agent.
SGTC_2743 auranofin 4.32 µM 0.735828720299436 0.189572822810157 no 639 0.2309174702307 219 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.735719304515638 0.189606714404521 no 640 0.230950769482342 267 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_115 0527-0192 112.043 µM 0.734601361099667 0.18995321151743 no 641 0.23129115441293 285 4233931
SGTC_2189 6047310 154.431 µM 0.73355591862166 0.190277589538104 no 642 0.231609717719421 256 711535
SGTC_1185 1319-0113 81.3 µM 0.733069482336209 0.190428636047953 no 643 0.231758026081203 257 4672763
SGTC_464 bw-b 70c 158 µM 0.732193408964198 0.190700856976589 no 644 0.23202526334168 275 5353454
SGTC_737 1950-0117 57.9 µM 0.731753419426295 0.190837664296746 no 645 0.232159542361512 261 5393513
SGTC_1084 voriconazole 435 nM 0.731431018187365 0.190937947737658 no 646 0.232257962429962 281 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1223 0764-0573 147 µM 0.731123835804976 0.191033527394988 no 647 0.232351758201738 243 1609797
SGTC_3342 9147791 14.508 µM 0.728337082794795 0.191901964291902 no 648 0.233203633749411 253 1838168
SGTC_593 1203-0218 61.7 µM 0.725118094570756 0.192908101330596 no 649 0.234189792298548 258 3666956
SGTC_847 0342-0274 5.54 µM 0.724733964379386 0.193028381079019 no 650 0.234307627155271 267 18097
SGTC_568 1193-0097 7.48 µM 0.723840126927245 0.19330843876559 no 651 0.234581945569249 247 3646150
SGTC_846 0335-0850 148 µM 0.722645849811255 0.193683017140226 no 652 0.234948745879351 260 6819598
SGTC_1762 st045503 25.4615 µM 0.722266765729439 0.193802007227808 no 653 0.235065240830915 258 4645554
SGTC_1813 st051246 8.6015 µM 0.722050400251775 0.193869941807727 no 654 0.235131745619935 245 5291959
SGTC_2767 sibutramine 71.45 µM 0.721873047278619 0.193925638038117 no 655 0.235186266788827 259 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1397 3532-0190 20.1 µM 0.721427089612216 0.194065730426054 no 656 0.235323392222516 235 5322280
SGTC_1096 rimcazole 32.2 µM 0.72126317914302 0.194117236475468 no 657 0.235373803374697 259 18528119 A dopamine reuptake inhibitor.
SGTC_2955 9076254 12.21 µM 0.720786732706106 0.194266998859549 no 658 0.235520369731898 244 16459619
SGTC_2177 5811945 192 µM 0.720269296818849 0.19442972521848 no 659 0.235679602451831 255 5343475
SGTC_330 1488-0319 80.1 µM 0.718339360541418 0.195037394762887 no 660 0.236274033245131 266 6846614
SGTC_2592 piperlongumine 83.33 µM 0.718286056877352 0.195054194593782 no 661 0.236290462769226 266 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3129 9127257 49.47 µM 0.718165908910638 0.195092065113849 no 662 0.236327497688228 268 837894
SGTC_2425 5628681 7.85 µM 0.717059145158533 0.195441126121766 no 663 0.236668801515536 279 5714958
SGTC_456 gingerol 170 µM 0.716166583734434 0.195722906223644 no 664 0.236944247015213 293 442793 A herb.
SGTC_3020 9089140 49.47 µM 0.715670721420669 0.195879555600933 no 665 0.237097346815502 256 17217859
SGTC_214 4373-3496 70 µM 0.715429380472861 0.19595582587357 no 666 0.237171881619408 274 3779166
SGTC_1654 st012436 41.8 µM 0.714819688408398 0.196148585306746 no 667 0.23736023387822 266 4323132
SGTC_2654 protoveratrine a 100 µM 0.713623571906592 0.196527081839423 no 668 0.237729988835423 287 5702278 A heart drug and vasodilator.
SGTC_1707 st032323 6.317 µM 0.71353293337839 0.196555781327079 no 669 0.237758020756072 257 3132057 YMR211W DML1
SGTC_3069 9117009 49.47 µM 0.711028974632823 0.197349630357079 no 670 0.238533140492507 247 41904981
SGTC_519 k048-0011 62.8 µM 0.710583560177732 0.197491046361296 no 671 0.23867116674414 257 6836379
SGTC_1346 1488-2224 62.4 µM 0.707965789380223 0.19832340798428 no 672 0.239483251274932 260 3722427
SGTC_1235 benzylparaben 21.5 µM 0.70648081348642 0.198796519268631 no 673 0.239944590140742 274 7180
SGTC_1484 3473-2379 286 µM 0.704036310629072 0.199576814882981 no 674 0.240705080605032 267 671917
SGTC_111 0083-0039 52.457 µM 0.703459092706791 0.199761333923231 no 675 0.240884845691397 241 759313
SGTC_1263 0774-1208 64.8 µM 0.701755644609538 0.20030647255983 no 676 0.241415782291353 290 906585
SGTC_2861 9024595 19.48 µM 0.701245467770892 0.200469913477702 no 677 0.241574919591762 242 16482810
SGTC_2759 disulfiram 3.38 µM 0.700892947233438 0.200582894196467 no 678 0.241684913098032 262 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1896 st058441 89 µM 0.700800787851632 0.200612437028737 no 679 0.241713673162943 258 688759
SGTC_1877 wortmannin 25 µM 0.699651056196206 0.200981217317831 no 680 0.242072624604412 271 312145 A covalent inhibitor of PI 3-kinase.
SGTC_459 nigericin 15.3 µM 0.697750581100219 0.201591692069646 no 681 0.242666594808833 291 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1270 0831-1170 17.3 µM 0.697248412347759 0.201753185166869 no 682 0.242823673187965 271 6764716
SGTC_373 0844-0104 25.9 µM 0.697143833600485 0.20178682652592 no 683 0.242856392340133 267 5375804
SGTC_980 1473-0395 201 µM 0.696833821222811 0.20188657242998 no 684 0.242953398742163 284 768876
SGTC_168 3970-0862 530.542 µM 0.695166579905942 0.202423510270018 no 685 0.243475456850808 281 3135186
SGTC_107 0358-0022 2.6945 µM 0.695023033582034 0.202469779493039 no 686 0.243520433383993 288 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.694592496023905 0.202608592392868 no 687 0.243655358119861 287 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1330 1469-0054 61.8 µM 0.693597461518662 0.20292962663504 no 688 0.243967343067168 273 7102664
SGTC_3040 9091894 49.47 µM 0.692686499794949 0.203223802177207 no 689 0.244253156546201 238 25236966
SGTC_1483 3453-0561 55.9 µM 0.692196295371463 0.203382208459553 no 690 0.244407032442899 285 4546991
SGTC_1021 4476-0760 85.3 µM 0.691071883520854 0.203745832811988 no 691 0.24476018423164 259 746768
SGTC_478 N-arachidonylglycine 10 µM 0.690643341403727 0.203884521296222 no 692 0.244894851676149 236 5283389
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.690477514591701 0.203938202688857 no 693 0.244946972708358 265 688669
SGTC_2215 7188065 200 µM 0.688144220787863 0.204694428294599 no 694 0.245680982823665 273 940217
SGTC_2933 9026794 32.47 µM 0.68810637712534 0.204706707238992 no 695 0.245692897450397 269 17586027
SGTC_3089 9117425 49.47 µM 0.687160886137693 0.205013628182003 no 696 0.245990674722409 292 9401657
SGTC_1218 1348-1416 30.7 µM 0.686960997493625 0.20507855012637 no 697 0.246053653356588 269 6787668
SGTC_1642 st009582 77.7 µM 0.686358673687522 0.205274253081812 no 698 0.246243478960877 287 6739311
SGTC_3128 9127691 49.47 µM 0.685621774481966 0.205513832198654 no 699 0.246475823483336 276 41316314
SGTC_1098 clofazimine 15.1 µM 0.6855781472467 0.205528021397052 no 700 0.246489582844866 287 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3044 9093193 49.47 µM 0.684120463254875 0.206002448716875 no 701 0.24694955055081 282 25236277
SGTC_67 0335-0847 266 µM 0.683928911356967 0.206064840691411 no 702 0.24701002829053 290 4552207 YOR254C SEC63
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.683678858062351 0.20614630450576 no 703 0.247088988311653 290 688751
SGTC_415 dibenzyl ketone 100 µM 0.683101109904601 0.20633459966408 no 704 0.247271477072143 291 7593
SGTC_1830 st055982 50.3 µM 0.680723547416886 0.207110548313289 no 705 0.248023216836348 303 455313 An antimicrobial agent.
SGTC_1701 st028638 40.4 µM 0.680593074287999 0.20715317983229 no 706 0.2480645052077 275 3490878
SGTC_2766 oltipraz 83.91 µM 0.680582705784754 0.207156567917584 no 707 0.24806778648972 275 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3225 9130819 49.47 µM 0.680473755254294 0.207192171343529 no 708 0.248102267062599 298 4547121
SGTC_571 k831-0106 44.2 µM 0.680283496444395 0.207254353793253 no 709 0.24816248614174 290 4783639
SGTC_1468 k284-1086 134 µM 0.678772673334416 0.207748529053529 no 710 0.248640955462678 272 15996457
SGTC_557 1315-0110 16.2 µM 0.676705968071088 0.208425653919256 no 711 0.249296264564274 263 6833801
SGTC_3117 9124945 49.47 µM 0.675225236059131 0.20891159283367 no 712 0.249766337806342 264 17592065
SGTC_3151 9099821 49.47 µM 0.675024859553011 0.208977402582319 no 713 0.249829985473816 286 17174189
SGTC_2126 5251174 33.877 µM 0.674631697463535 0.209106564467996 no 714 0.249954894643271 272 790722
SGTC_907 3448-6986 75.5 µM 0.674117277885579 0.209275632918425 no 715 0.250118377840851 287 590582
SGTC_2840 9008771 71.43 µM 0.673798889801198 0.209380314218383 no 716 0.250219590389223 228 2992978
SGTC_2229 7354935 190 µM 0.673532757764047 0.209467838139233 no 717 0.250304207898446 289 318112
SGTC_1243 0416-0003 5.65 µM 0.673492328134961 0.209481136278203 no 718 0.25031706395212 289 2141977
SGTC_2598 perillyl alcohol 100 µM 0.673195599336668 0.209578751699597 no 719 0.250411430250678 275 10819 An apoptosis inducer.
SGTC_1764 st044502 93.5 µM 0.672056149071948 0.209953847311192 no 720 0.250773975704034 271 8407
SGTC_2951 9072950 58.06 µM 0.67029317134526 0.2105349786845 no 721 0.251335459677795 284 16488155
SGTC_3150 9097574 49.47 µM 0.669299629966718 0.210862895785997 no 722 0.251652181401561 268 17217476
SGTC_282 k297-0036 65.7 µM 0.668453610906516 0.211142359287003 no 723 0.2519220419593 287 5061378
SGTC_2533 agelasine 13.65 µM 0.66791110582405 0.211321677886829 no 724 0.252095168899181 271 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2888 9058547 12.99 µM 0.666894544380459 0.211657930273542 no 725 0.252419747995558 266 16476514
SGTC_1296 1068-0102 11.9 µM 0.666649557084391 0.211739012577945 no 726 0.252498003200028 277 767053
SGTC_1101 ebselen 5.29 µM 0.665980356892487 0.211960587268645 no 727 0.252711827981473 284 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.664207205299986 0.212548339743381 no 728 0.253278851242655 295 689007
SGTC_1637 st007924 17.4 µM 0.66138251714476 0.213486612091848 no 729 0.254183517424951 271 683336
SGTC_1320 1313-0481 95.3 µM 0.659960418027622 0.213959900693678 no 730 0.254639615259446 275 6813365 YLR208W SEC13
SGTC_418 lividomycin a 100 µM 0.659547628626608 0.214097395372242 no 731 0.254772085936428 285 72394 An antibiotic.
SGTC_2627 acetyl isogambogic acid 100 µM 0.658785485139635 0.214351390333061 no 732 0.255016764660413 289 6857789 A caspase activator and apoptosis inducer.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.657964667020438 0.21462513534566 no 733 0.255280417735574 297 442882
SGTC_2845 9003024 42.97 µM 0.65667597475937 0.215055327304136 no 734 0.255694642881781 261 2990173
SGTC_2711 st079103 59.1 µM 0.656608998784606 0.215077698938672 no 735 0.25571618060053 285 54693780
SGTC_811 0416-0114 265 µM 0.655241158961572 0.215534886822792 no 736 0.256156249177154 289 6612453
SGTC_1181 1222-0449 220 µM 0.655139014530523 0.215569050261067 no 737 0.256189127456716 284 658318
SGTC_769 0302-0231 76 µM 0.653253942811291 0.216200098781974 no 738 0.256796289681648 302 571869 YER009W NTF2
SGTC_738 1315-0003 72.4 µM 0.653140441790319 0.216238128609543 no 739 0.25683287108524 312 6251474
SGTC_1967 st070177 51.4 µM 0.650766696259687 0.217034366550614 no 740 0.257598550821182 296 5729214
SGTC_1998 st075797 76.8 µM 0.648829844451764 0.217685308331032 no 741 0.258224182380796 282 24208315
SGTC_1092 toremifene 6.32 µM 0.646143492800637 0.218590005821636 no 742 0.259093215370743 308 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_390 dec-rvkr-cmk 16.7 µM 0.645640689849692 0.218759577721751 no 743 0.259256039638867 284 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2847 9005661 71.43 µM 0.643797493289154 0.219381848673479 no 744 0.259853379740125 269 2991449
SGTC_1398 3558-0053 112 µM 0.642216166047155 0.219916521111373 no 745 0.260366418970217 276 4532369
SGTC_1793 st048256 72.231 µM 0.641687479982164 0.22009544512188 no 746 0.260538059988743 293 672022
SGTC_841 0251-0215 91.2 µM 0.641480175603363 0.220165626234827 no 747 0.260605378462926 299 3888614
SGTC_106 0092-0003 11.579 µM 0.639562084696346 0.220815587854496 no 748 0.261228669378139 282 1072148
SGTC_466 geldanamycin 89.2 µM 0.638725370731898 0.221099459403608 no 749 0.261500802501388 268 5288382 HSP90 inhibitor.
SGTC_683 panaxydol 45 µM 0.635277674284237 0.222271358302126 no 750 0.262623665883944 259 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1334 1486-0610 236 µM 0.635032927514856 0.222354684142907 no 751 0.262703469947014 284 3742339
SGTC_2863 9028737 58.44 µM 0.635003052648269 0.222364856481501 no 752 0.262713212031303 301 6460917
SGTC_2957 9076800 11.52 µM 0.633837935074682 0.222761783935428 no 753 0.263093296697591 298 16459615
SGTC_1351 1496-0003 46.5 µM 0.632091726076784 0.223357430606412 no 754 0.263663470700487 288 3891978
SGTC_1868 st057644 42.7 µM 0.631053681668081 0.223711945429201 no 755 0.264002712540508 289 688665
SGTC_2075 5212009 200 µM 0.629434855321273 0.224265447912455 no 756 0.264532202482929 304 780898
SGTC_2098 5376439 882.5 nM 0.629050533613793 0.22439696773412 no 757 0.264657986748381 286 2844116
SGTC_3253 9135987 49.47 µM 0.627973611652975 0.224765737360847 no 758 0.265010613430501 287 4182430
SGTC_52 0329-0193 875 nM 0.627188303177184 0.225034866515562 no 759 0.265267904786977 315 3739292
SGTC_2420 aureobasidin a 50 nM 0.626857919092677 0.225148145349328 no 760 0.265376186722873 276 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_64 000l-0018 272.079 µM 0.625130029034707 0.225741113236514 no 761 0.265942860328679 289 6811119
SGTC_1469 k284-2957 126 µM 0.624635800717501 0.225910882152775 no 762 0.266105058638767 290 23884841
SGTC_2159 5658611 73.75 µM 0.624111674584274 0.226090999908223 no 763 0.26627712367884 315 793844
SGTC_746 1095-0025 46.6 µM 0.621383154562273 0.227029975224735 no 764 0.267173776488963 304 6749286
SGTC_842 0271-0008 11.1 µM 0.620993223942417 0.227164342778952 no 765 0.267302040779517 279 1221709
SGTC_2114 5491910 81.25 µM 0.619947027623225 0.227525076610967 no 766 0.267646331412128 304 2849228
SGTC_2875 9039966 71.43 µM 0.619656701611762 0.227625239655357 no 767 0.267741913817411 310 6463691
SGTC_865 0488-0499 301 µM 0.619290861495256 0.227751490558599 no 768 0.267862381795806 276 9634651
SGTC_1740 st038286 13.222 µM 0.617941601082689 0.228217458971999 no 769 0.26830691745635 276 716786
SGTC_3027 9089541 49.47 µM 0.615672823248774 0.229002190579116 no 770 0.269055238681935 294 9943819
SGTC_1116 jasmonic acid 1.58368 µM 0.614918726390972 0.229263354675407 no 771 0.269304197582582 322 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1856 st057054 55.7 µM 0.614698781477827 0.22933955898076 no 772 0.269376832349022 317 1266018
SGTC_1272 0839-0021 27 µM 0.614426869114241 0.229433788071442 no 773 0.269466642459107 318 5027250
SGTC_2837 9008476 45.46 µM 0.61442282564561 0.229435189467402 no 774 0.269467978092213 309 2992805
SGTC_2938 9059746 27.26 µM 0.614152549659645 0.229528873303948 no 775 0.269557262814522 306 6471769
SGTC_2555 cholic acid 100 µM 0.613289318027827 0.229828232631061 no 776 0.269842527597839 288 6708657 Influences liver metabolism.
SGTC_817 1391-0715 46 µM 0.613247833809869 0.229842624408912 no 777 0.269856240338259 322 1353946
SGTC_355 1311-2252 105 µM 0.612295460850823 0.230173162031605 no 778 0.270171146161121 314 5338538
SGTC_1801 st050089 28.441 µM 0.611879994374763 0.230317440168578 no 779 0.270308579322083 286 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_570 0987-0065 62.6 µM 0.611336293713527 0.230506326281981 no 780 0.270488484161013 296 3104428
SGTC_1833 st055984 71 µM 0.610296867905795 0.23086767228421 no 781 0.270832585678426 298 676288
SGTC_2821 7996764 71.43 µM 0.607309846476005 0.231907839014196 no 782 0.271822652523873 248 2987135
SGTC_1277 0873-0036 22 µM 0.606277639082705 0.232267889173535 no 783 0.272165202308584 296 5965735
SGTC_1746 st038117 42 µM 0.604462011430008 0.232901962682672 no 784 0.272768259217261 290 2898218
SGTC_932 2857-0803 154 µM 0.602744841199297 0.233502535513823 no 785 0.273339223034802 305 674898
SGTC_725 1497-0963 19 µM 0.602201584588195 0.233692715860052 no 786 0.273519980518079 300 3549977
SGTC_2905 7799065 20.05 µM 0.600760335818836 0.234197676311169 no 787 0.273999812956592 305 1296806
SGTC_95 0471-0001 561.058 µM 0.600748417784047 0.234201854468129 no 788 0.274003782540728 283 4015405
SGTC_1800 st050079 29.0735 µM 0.600502215699583 0.234288175828091 no 789 0.274085792341349 310 3645560
SGTC_2088 5278280 127.392 µM 0.599246674353975 0.234728657244483 no 790 0.274504201105557 308 791502
SGTC_35 0133-0054 64.071 µM 0.598890123813317 0.234853829251108 no 791 0.274623078895346 298 99677
SGTC_2216 7189485 200 µM 0.59830864984035 0.235058042864498 no 792 0.274817003036442 297 731273
SGTC_1920 st075728 45.7 µM 0.598105989764094 0.235129240112206 no 793 0.27488460692749 320 3400306
SGTC_1795 st049545 62.3 µM 0.597046343991307 0.235501702001713 no 794 0.275238219806891 271 5291882
SGTC_2628 lathosterol 100 µM 0.596762165764226 0.23560164501535 no 795 0.275333090583685 291 6710616
SGTC_1771 st048882 4.1505 µM 0.596510790200041 0.235690071115638 no 796 0.275417023848295 284 4580403
SGTC_371 0195-0006 7.36 µM 0.594868048877275 0.236268386793751 no 797 0.275965838138789 294 3928593
SGTC_2205 7238770 200 µM 0.593015235489194 0.236921593493735 no 798 0.276585478068172 309 279867
SGTC_3257 9139206 32.98 µM 0.592940207404769 0.23694806543529 no 799 0.276610584214255 304 4910041
SGTC_1077 5-fluorocytosine 377 nM 0.59287474356892 0.236971164178874 no 800 0.276632490852238 331 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2914 7968218 45.32 µM 0.592424975712241 0.237129897051923 no 801 0.276783022915868 291 2977111
SGTC_3125 9127534 49.47 µM 0.590404839805656 0.237843566952995 no 802 0.277459633316605 286 1639235
SGTC_812 4251-0442 148 µM 0.590185841803151 0.237921004869956 no 803 0.277533031543574 318 5723007
SGTC_1948 st076329 66.6 µM 0.590070707224722 0.237961722117809 no 804 0.277571623252843 309 24208413
SGTC_1231 0242-0792 125 µM 0.589902929211097 0.238021063511709 no 805 0.277627865094951 317 3707635
SGTC_2895 9054447 58.44 µM 0.589358399647475 0.238213714007652 no 806 0.277810438358106 319 2697450
SGTC_2619 obliquin 87.91 µM 0.588240309134694 0.238609553739325 no 807 0.278185502367413 309 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2620 irigenin 100 µM 0.586342325888395 0.239282323821258 no 808 0.278822746588539 308 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3136 9095672 49.47 µM 0.584303684577164 0.240006105215677 no 809 0.279508006832132 299 17217380
SGTC_3105 9121040 49.47 µM 0.58315920170245 0.240412955020625 no 810 0.279893066540189 266 41448907
SGTC_425 3825-7017 13.1 µM 0.582720874265041 0.240568874546841 no 811 0.280040609313552 312 3397440
SGTC_1267 0828-0272 9.49 µM 0.579024136253406 0.2418860462837 no 812 0.281286443666099 305 745334
SGTC_1466 k213-0079 57.5 µM 0.578623366846386 0.242029077734877 no 813 0.281421667199454 329 3657981
SGTC_877 0771-0151 33.1 µM 0.578501679605414 0.24207251603097 no 814 0.281462731876974 308 6166523
SGTC_1161 k007-0610 110 µM 0.576353078576587 0.242840190975605 no 815 0.282188276353126 311 5843850
SGTC_775 4577-0580 57.3 µM 0.575851849606107 0.243019464698802 no 816 0.282357661899959 322 2006902
SGTC_2027 5150920 200 µM 0.57570993380391 0.243070236485478 no 817 0.282405629874352 309 786715
SGTC_2107 5363541 170.161 µM 0.575006066312129 0.243322136827736 no 818 0.282643597147256 304 244052
SGTC_1304 1165-0502 251 µM 0.574647231542269 0.243450611015665 no 819 0.282764950997064 300 767425
SGTC_2593 nobiletin 86.24 µM 0.574081920129864 0.243653084691055 no 820 0.282956183671341 289 72344 An anti-infammatory.
SGTC_939 1165-0479 45.3 µM 0.574077623464536 0.243654623946026 no 821 0.282957637378408 325 1377347
SGTC_617 3770-0098 35 µM 0.573659023812159 0.243804609969425 no 822 0.283099280974379 314 5962639
SGTC_2752 diclazuril 33.15 µM 0.573626981256428 0.243816093005376 no 823 0.283110124771315 317 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2557 derrustone 83.84 µM 0.572360629227547 0.244270147064127 no 824 0.283538841373398 328 629853 An antioxidant.
SGTC_1560 lithocholic acid 53.1 µM 0.570443978923076 0.2449582335055 no 825 0.284188304053767 308 9903 A bile acid which acts as a detergent.
SGTC_2199 6590217 200 µM 0.570035846894486 0.245104889381566 no 826 0.284326692617049 310 703109
SGTC_3195 9113082 49.47 µM 0.569901887142843 0.245153036019777 no 827 0.284372122431958 313 17018038
SGTC_564 3555-0129 330 µM 0.569598323477084 0.2452621590268 no 828 0.284475082912784 305 563260
SGTC_1578 josamycin 24.2 µM 0.569285755865503 0.245374545992048 no 829 0.284581115889689 302 5282165 A P450 substrate.
SGTC_955 1216-0110 33 µM 0.569070299710953 0.24545203162567 no 830 0.284654216526741 327 3619719
SGTC_1410 3909-8106 77.9 µM 0.569007694850553 0.245474549006883 no 831 0.284675458980046 328 1039210
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.568475529060918 0.245666000358708 no 832 0.28485605868796 309 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.568183253055031 0.245771183341718 no 833 0.284955270878722 300 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2659 sanguinarine 24.21 µM 0.567899382343873 0.245873364604672 no 834 0.285051645691314 323 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_475 α-linolenic acid 10 µM 0.566753306541031 0.246286134417356 no 835 0.285440899221474 309 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_682 0kpi-0099 17 µM 0.56579882795808 0.246630182042117 no 836 0.285765271658875 314 1714895 YML126C ERG13
SGTC_2986 9022445 71.43 µM 0.564422073667324 0.247126894607912 no 837 0.286233459950227 332 6459286
SGTC_2658 polymyxin b sulfate 77.05 µM 0.563553938777331 0.247440379683399 no 838 0.286528870864131 307 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.563368723104598 0.247507288892845 no 839 0.286591915190662 340 7104
SGTC_527 4476-4215 268 µM 0.562230247400908 0.247918775780879 no 840 0.286979577779247 301 4418754
SGTC_3219 9131112 49.47 µM 0.561637479603528 0.248133168262907 no 841 0.287181519546093 299 17612988 YMR079W SEC14
SGTC_1233 0325-0408 14.2 µM 0.560734101367413 0.24846009254635 no 842 0.287489408146213 335 12874
SGTC_2670 beta-carotene 100 µM 0.558478874446845 0.2492772392132 no 843 0.288258713128954 294 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_546 peri-Naphthalide 147 µM 0.558030459537405 0.249439885572363 no 844 0.288411792456142 299 223824 A penicillin ester.
SGTC_2789 5281112 71.43 µM 0.557885043580678 0.249492642081556 no 845 0.288461442602717 310 765948
SGTC_1056 3448-1962 115 µM 0.554695583150135 0.250651259214766 no 846 0.289551448902879 321 715507
SGTC_3126 9127922 49.47 µM 0.554405270589962 0.25075686073168 no 847 0.289650759919993 361 45595682
SGTC_1946 st076057 65.1 µM 0.554054388580676 0.250884525890111 no 848 0.289770812056859 320 953009
SGTC_3201 9113999 49.47 µM 0.552337716296282 0.251509616729898 no 849 0.290358497252409 332 16649224
SGTC_2835 9006588 71.43 µM 0.552292310315773 0.251526161546165 no 850 0.290374049098565 280 2345538
SGTC_1197 1601-0112 267 µM 0.551098670756115 0.25196130045725 no 851 0.290783018295629 319 7350313
SGTC_2591 skatole 100 µM 0.549953112837199 0.252379284586621 no 852 0.291175766660035 341 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3063 1327-0034 4 µM 0.548605563948774 0.252871437388261 no 853 0.291638083335559 327 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2336 9001819 198.65 µM 0.54752451667189 0.253266623158862 no 854 0.292009215909005 335 2989602
SGTC_443 clozapine 122 µM 0.546995630397342 0.25346008013625 no 855 0.292190867059347 334 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1281 0884-0031 11.8 µM 0.545869108126268 0.253872400195998 no 856 0.292577957279335 328 1548255
SGTC_3081 9117243 49.47 µM 0.545773090120959 0.253907560161708 no 857 0.292610961546449 335 45595589
SGTC_1652 st011932 78 µM 0.544951065091045 0.25420867464288 no 858 0.292893586959981 313 1551076
SGTC_569 4130-2812 160 µM 0.544879942879626 0.254234736088476 no 859 0.2929180458732 335 743552
SGTC_2496 diffractaic acid 79.83 µM 0.543899044794596 0.254594311266349 no 860 0.293255473160949 330 94870 An apoptosis inducer which activates caspases.
SGTC_344 k064-0035 6.43 µM 0.543668759845885 0.254678767143863 no 861 0.293334716903285 336 5088750
SGTC_2313 7726885 200 µM 0.543140406723951 0.254872593496729 no 862 0.293516566879336 306 726423
SGTC_2276 7947513 42.08 µM 0.542763916340845 0.255010756095311 no 863 0.293646180184482 315 2105100
SGTC_984 1492-0255 2.91 µM 0.542123561966996 0.255245840179957 no 864 0.293866694051508 338 1585198
SGTC_905 2-aminofluorene 215 µM 0.540893918067301 0.255697579131055 no 865 0.294290351599269 318 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1117 retinoic acid 1.10837 µM 0.54060327067528 0.255804416333516 no 866 0.294390531518765 331 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1198 1612-1005 86.7 µM 0.540560100350695 0.255820287022326 no 867 0.294405412746212 328 6998509
SGTC_1140 3229-1848 2.98 µM 0.539635360238032 0.256160372232184 no 868 0.294724262946582 332 2849525
SGTC_3261 9137475 49.47 µM 0.537057379616959 0.257109701413544 no 869 0.295613989817981 298 17027690
SGTC_1798 st045719 60.953 µM 0.536819595346012 0.257197356417007 no 870 0.295696117393189 348 3980186
SGTC_3109 9122853 49.47 µM 0.536664237155825 0.257254634881102 no 871 0.295749781741653 367 1234709
SGTC_3137 9097352 49.47 µM 0.536133662516323 0.257450300556731 no 872 0.29593308834636 358 44120435
SGTC_873 0591-4978 488 µM 0.533344509645787 0.258480156333809 no 873 0.296897561008942 332 3305145
SGTC_800 3448-7362 155 µM 0.532929296340974 0.258633650325884 no 874 0.297041262239822 327 15991913
SGTC_1872 amphotericin b 148 nM 0.532826488961762 0.258671662934891 no 875 0.297076847772682 331 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1343 1487-0095 224 µM 0.532824121957867 0.258672538158984 no 876 0.297077667105455 355 4560101 YGL055W OLE1
SGTC_2807 7945238 51.95 µM 0.531857903377167 0.259029935437005 no 877 0.297412207637637 343 17148797
SGTC_245 methotrexate 289.6 µM 0.53138113531092 0.259206382548621 no 878 0.297577345712561 311 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3131 9127911 49.47 µM 0.531040862716782 0.25933235202747 no 879 0.297695231463662 302 45595681
SGTC_990 3985-0011 41.3 µM 0.528464068644207 0.260287311169353 no 880 0.298588639789403 346 5399565 YGL099W LSG1
SGTC_2319 6033012 152.6 µM 0.528151964626005 0.260403099725557 no 881 0.298696933091641 315 847246
SGTC_1026 k007-1105 30.6 µM 0.526183594312161 0.261133963091094 no 882 0.299380325782171 323 7066794
SGTC_987 1497-1013 404 µM 0.526153092127912 0.261145296957539 no 883 0.299390921322616 330 1676435
SGTC_2073 5212005 126 µM 0.526112656660098 0.261160322179187 no 884 0.299404967648828 361 691789
SGTC_178 4092-0806 87.505 µM 0.526033940992235 0.2611895730311 no 885 0.299432312469197 315 2169044
SGTC_190 3970-0790 3.722 µM 0.524816618281011 0.261642146091573 no 886 0.299855338953252 327 2832352
SGTC_2747 doxorubicin 7.63 µM 0.524106177253923 0.261906457850999 no 887 0.300102346160361 294 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3279 9140807 49.47 µM 0.523647262601558 0.262077264752371 no 888 0.300261951206479 320 45595718
SGTC_2887 9044784 58.44 µM 0.523561295456113 0.262109267860024 no 889 0.300291853821624 318 6465546
SGTC_8 0354-0001 70 µM 0.521824732527339 0.262756169111227 no 890 0.300896183873637 340 4993152
SGTC_1628 st004252 77.7 µM 0.521110033341883 0.263022644566066 no 891 0.301145060941226 319 692968
SGTC_2060 5238662 140 µM 0.520193526394376 0.263364566024902 no 892 0.301464348441307 328 790130
SGTC_758 0868-0029 16 µM 0.519475113139535 0.263632743204571 no 893 0.301714731644836 310 762687
SGTC_685 1278-0033 54.9 µM 0.519225701993643 0.263725878701142 no 894 0.301801678908063 351 3590572
SGTC_3325 9138760 55.175 µM 0.519189812954318 0.263739281822806 no 895 0.301814191119178 307 43844959
SGTC_804 1595-0054 20.9 µM 0.515504698849685 0.265117371402074 no 896 0.303100193465845 336 761523 Stimulates phospholipase C.
SGTC_2856 9022925 19.48 µM 0.514554683091 0.265473232445647 no 897 0.30343211952158 308 4944862
SGTC_3288 9119690 36.221 µM 0.514407247923646 0.265528481069308 no 898 0.30348364645603 354 17595618 YKL019W RAM2
SGTC_1152 3909-8331 15.9 µM 0.511620496331904 0.266573860958032 no 899 0.304458318943547 357 16001939
SGTC_1944 st076371 56.9 µM 0.511469065882172 0.266630725850412 no 900 0.304511321962665 323 24208455
SGTC_2781 5567276 71.43 µM 0.511434907460482 0.266643553807694 no 901 0.304523278510494 346 2853274
SGTC_1373 2887-0003 58.5 µM 0.511388976659585 0.266660803291818 no 902 0.304539356099499 341 776948
SGTC_1188 1403-0014 4.57 µM 0.511143636989354 0.266752951076442 no 903 0.304625241040589 316 9614867
SGTC_903 1134-0042 114 µM 0.510511692343056 0.266990378952434 no 904 0.304846512618927 332 701009
SGTC_2911 7942208 15.64 µM 0.509217074546237 0.267477112767115 no 905 0.305300038058173 304 1243384
SGTC_283 0987-0079 11.7 µM 0.508990105243585 0.267562491857473 no 906 0.30537957988527 333 411556
SGTC_819 1013-0258 27.7 µM 0.508762772239757 0.267648021532354 no 907 0.305459258383851 328 5753198
SGTC_397 arbidol 50 µM 0.508603061393784 0.267708117910036 no 908 0.305515241339369 328 131410 A RNA synthesis inhibitor.
SGTC_1201 1889-3372 45.9 µM 0.507714606970798 0.268042551740112 no 909 0.305826751542248 319 5392199
SGTC_1259 0671-0132 43 µM 0.506434596442485 0.268524745431848 no 910 0.306275796347776 317 X1259
SGTC_444 curcumin 90.4 µM 0.506304058502845 0.26857394496453 no 911 0.306321607173288 338 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_208 k072-0098 12.366 µM 0.506193850474608 0.268615485714341 no 912 0.306360285801698 334 5948901
SGTC_2473 5854593 8.94 µM 0.505827340674446 0.268753657599549 no 913 0.306488931662235 351 2872951
SGTC_2935 9038016 29.96 µM 0.505194887042776 0.268992172564667 no 914 0.306710980560389 333 6463195
SGTC_3042 9091578 49.47 µM 0.50434996579631 0.269310980386282 no 915 0.307007735674465 323 25236497
SGTC_702 1488-0190 94 µM 0.503932477797969 0.269468577927918 no 916 0.30715441343465 313 949357
SGTC_2190 6049624 200 µM 0.50217749091667 0.270131573091516 no 917 0.307771337455297 342 2265554
SGTC_588 3970-1144 52.9 µM 0.496877254980862 0.272138825166214 no 918 0.309637805923984 337 1888707
SGTC_985 1493-0307 8.71 µM 0.496278289268037 0.272366124857615 no 919 0.309849040884195 362 3278274
SGTC_333 3486-0131 40.1 µM 0.493985057875933 0.273237247107295 no 920 0.310658366076443 347 6744690
SGTC_1402 3909-7673 35.9 µM 0.492907985497796 0.273646866880133 no 921 0.311038802308622 332 5328014
SGTC_862 0452-0056 10.2 µM 0.492683822616459 0.273732156107857 no 922 0.311118005017411 334 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1687 st020778 55.3625 µM 0.492565799248079 0.273777066782578 no 923 0.31115970932847 323 4259299
SGTC_1696 st025591 34.7925 µM 0.489652960352783 0.27488662406684 no 924 0.312189746775679 333 2787147
SGTC_3336 9143619 71.43 µM 0.489001683709298 0.275135010878602 no 925 0.312420252418481 325 45595730
SGTC_2698 st077697 67.5 µM 0.488792219205114 0.275214920875406 no 926 0.312494403573462 337 3154499
SGTC_3313 9133968 57.047 µM 0.488053650668528 0.275496773402466 no 927 0.312755919940498 329 1494643
SGTC_480 am 92016 50 µM 0.487698291257532 0.27563243623447 no 928 0.312881781136907 368 2129 K+ channel blocker.
SGTC_403 arphamenine a 50 µM 0.486746335434392 0.275996018861664 no 929 0.313219052310481 361 5487158 An arginine aminopeptidase inhibitor.
SGTC_55 0767-0285 6.563 µM 0.486553481968868 0.276069704499513 no 930 0.313287397969722 360 3116166
SGTC_1935 st074532 41.6 µM 0.484185244060813 0.276975349877644 no 931 0.314127204074685 365 2829742
SGTC_1736 st036774 51 µM 0.483272963010241 0.277324605815095 no 932 0.31445096735405 358 1272247
SGTC_2248 tofa 1.1 µM 0.482301702598718 0.277696677836221 no 933 0.314795818979592 345 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.48106321983738 0.278171471217646 no 934 0.315235783791527 346 279621
SGTC_3242 9133940 49.47 µM 0.479049576661063 0.278944279595887 no 935 0.315951679966893 354 17248444
SGTC_1651 st011928 86.1 µM 0.478215886348695 0.279264543842247 no 936 0.316248278298296 346 720198
SGTC_1705 st027868 56.3335 µM 0.477013978540939 0.279726574041117 no 937 0.316676083870407 365 292948
SGTC_595 3909-8003 73.7 µM 0.475274948069603 0.280395737599286 no 938 0.317295506394295 355 699517
SGTC_246 cycloheximide 667 µM 0.474284267921784 0.280777288780914 no 939 0.31764860428253 343 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1278 0874-0585 172 µM 0.471961815786993 0.28167274241438 no 940 0.318477021942219 340 766306
SGTC_1930 st074634 34.3 µM 0.471594309464763 0.281814565656758 no 941 0.318608194634151 337 684253 YOR116C RPO31
SGTC_2365 9042475 200 µM 0.471337400460927 0.28191372905895 no 942 0.318699905731506 334 6464479
SGTC_109 0132-0036 33.701 µM 0.469032841060841 0.282804008760304 no 943 0.319523080931773 336 67274 A color developer.
SGTC_663 1486-0733 13.9 µM 0.468487880250504 0.283014731108974 no 944 0.319717868038877 357 722445 YPR165W RHO1
SGTC_1688 st021091 57.6 µM 0.467930892515722 0.283230181813457 no 945 0.319917005363756 363 3656366
SGTC_2794 7785382 27.27 µM 0.46572202472935 0.284085376794149 no 946 0.320707242589347 382 2205081
SGTC_342 k048-0088 23.3 µM 0.464801270942592 0.284442224257025 no 947 0.321036888772382 331 6820570
SGTC_1057 3448-5381 134 µM 0.463935516061262 0.284777951558152 no 948 0.32134697309266 335 5497911
SGTC_453 enantio-paf c16 10 µM 0.463912089965889 0.284787038488292 no 949 0.321355365265001 384 13871343 A lipid and platelet activating factor
SGTC_658 3253-0951 102 µM 0.463527947209123 0.284936066340769 no 950 0.321492993703607 362 1184878
SGTC_910 3454-3003 490 µM 0.459614927142695 0.286456234362742 no 951 0.322896321397311 370 820824
SGTC_2379 9035213 200 µM 0.459161681364911 0.286632564091665 no 952 0.323059032652138 366 646551
SGTC_2141 5621638 7.665 µM 0.457131613637137 0.287422968060754 no 953 0.323788224301332 349 2856238
SGTC_2352 9027995 87.8 µM 0.455978662516728 0.287872326455423 no 954 0.324202661002605 361 2997347
SGTC_507 nimesulide 162 µM 0.455827428884251 0.28793129380411 no 955 0.324257039214039 360 4495 A COX2 inhibitor.
SGTC_2396 5342950 42.78 µM 0.4541356060791 0.288591339116077 no 956 0.324865613564359 356 1886677
SGTC_2358 9037157 4 µM 0.454118065361507 0.288598186158274 no 957 0.324871925679174 343 2388925
SGTC_211 3455-0679 143.504 µM 0.4537254288396 0.288751472366741 no 958 0.325013231048537 337 748649
SGTC_2381 9035592 200 µM 0.453222811179012 0.288947751393072 no 959 0.325194154103942 347 4749657
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.453146812133707 0.288977435515997 no 960 0.325221514429953 382 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1430 4049-0248 69.1 µM 0.451777667352251 0.289512449155918 no 961 0.325714579889034 372 22774488
SGTC_1169 aniline yellow 25.8 µM 0.451468313362276 0.289633398212413 no 962 0.325826028770182 372 6051 A DNA damaging agent.
SGTC_218 alverine citrate 93.75 µM 0.451074703683886 0.289787323248042 no 963 0.32596785438365 375 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.450683920653791 0.289940180850914 no 964 0.326108686410373 350 75037 A free radical scavenger.
SGTC_1350 1495-0454 146 µM 0.446872289688438 0.291433106937248 no 965 0.327483636266188 371 1069057
SGTC_3071 9117417 49.47 µM 0.445898574242143 0.291815062630899 no 966 0.327835256098317 366 45595590 YGL055W OLE1
SGTC_1974 st069448 26.9 µM 0.445772049292148 0.291864711213289 no 967 0.327880956926757 337 6323587 YNR016C ACC1
SGTC_3213 9129884 49.47 µM 0.445619587321249 0.291924542748774 no 968 0.327936029634908 345 17190742
SGTC_1926 methyl fluorone black 53.6 µM 0.445149216752306 0.292109168985523 no 969 0.32810596168558 326 72721 Reacts with homocysteine.
SGTC_1841 st054148 70 µM 0.444378373872197 0.292411851749474 no 970 0.328384523111742 376 675442
SGTC_2331 7980721 200 µM 0.442595963625428 0.293112299093565 no 971 0.329029002425063 362 2981221
SGTC_2192 5915882 198.485 µM 0.439605604882431 0.294289187779263 no 972 0.330111390279552 351 2876149
SGTC_1619 st003326 88.7 µM 0.439213388413901 0.294443710658001 no 973 0.330253462427365 338 2849032
SGTC_2976 9009005 19.48 µM 0.43910590080119 0.294486064462077 no 974 0.330292401823024 347 2993148
SGTC_3303 9125618 40.5795 µM 0.439042061825803 0.294511220537627 no 975 0.330315529554387 370 22695467
SGTC_1279 0874-0590 65.2 µM 0.438172810961953 0.294853851939077 no 976 0.330630508237669 361 3523074
SGTC_1407 3909-7909 12.3 µM 0.437042280922532 0.295299746057522 no 977 0.331040342608613 352 4411780
SGTC_3144 9087057 49.47 µM 0.43695869014405 0.295332727544172 no 978 0.331070653586796 396 17249618
SGTC_1760 st045453 10.4495 µM 0.436907654052181 0.295352865122418 no 979 0.331089160405345 385 3323419 YIL048W NEO1
SGTC_1353 1498-1206 8.11 µM 0.436761159894431 0.295410671599194 no 980 0.331142284727373 356 6756808
SGTC_2186 6124449 200 µM 0.436715301326107 0.295428768422949 no 981 0.331158915477254 363 3834182 YLR033W RSC58
SGTC_506 n9-isopropylolomoucine 153 µM 0.43656282629365 0.29548894217058 no 982 0.331214213408105 372 6610355
SGTC_1646 st011709 75.6 µM 0.43599086434753 0.295714715201048 no 983 0.331421678931652 355 5757843
SGTC_2164 5685496 200 µM 0.435473932904187 0.295918833972699 no 984 0.331609227971511 340 759046
SGTC_2094 5332512 191.667 µM 0.435037955972742 0.296091036817442 no 985 0.331767438550521 366 755774
SGTC_2265 7929201 200 µM 0.433844110464292 0.296562818982811 no 986 0.332200823693614 414 1265108
SGTC_203 k066-0004 30.888 µM 0.432006847456025 0.29728953797769 no 987 0.33286821822009 364 6795412
SGTC_2777 climbazole 1.536 µM 0.431832350722788 0.297358601466205 no 988 0.332931632572624 349 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3115 9123671 49.47 µM 0.43170106704812 0.297410566631348 no 989 0.332979345895202 357 3286988
SGTC_2415 st077333 57.7 µM 0.431674839286041 0.297420948693312 no 990 0.332988878354028 408 2766255
SGTC_3004 9076122 71.4286 µM 0.431401155094795 0.297529294391935 no 991 0.333088355089025 391 44782551
SGTC_874 0599-0792 117 µM 0.428491340834685 0.298682339924795 no 992 0.334146718266168 380 765305
SGTC_221 trifluoperazine 10.304 µM 0.428185673778967 0.298803581645087 no 993 0.334257972834246 376 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_3260 9137109 49.47 µM 0.425887506769903 0.299715856504654 no 994 0.335094909411514 362 17478346
SGTC_2682 pyrogallin 40.03 µM 0.425688467293398 0.299794926065577 no 995 0.335167433367882 354 822798 An ATP competetive kinase inhibitor.
SGTC_1340 1486-1359 257 µM 0.42531555424219 0.299943093310478 no 996 0.335303328128508 364 4309068
SGTC_797 k781-0471 270 µM 0.424474054302434 0.30027756300204 no 997 0.335610061718962 382 23738129
SGTC_1796 st049173 110.4 µM 0.422785712086109 0.300949133695415 no 998 0.336225806536074 385 94134
SGTC_2925 9010536 32.5 µM 0.421889794496904 0.301305777018147 no 999 0.336552729736686 325 2994177
SGTC_1310 1188-0297 994 nM 0.420365257655786 0.3019130956404 no 1000 0.337109322096622 352 1588352
SGTC_134 0269-0018 6.916 µM 0.419725953209175 0.302167934261755 no 1001 0.337342831671141 372 4378915
SGTC_1312 1218-2183 165 µM 0.418068338902977 0.302829139373755 no 1002 0.337948576392606 354 6744073
SGTC_2196 6573537 42.6665 µM 0.416891261260515 0.303299056395539 no 1003 0.338378972859051 390 2903087
SGTC_2580 diallyl disulphide 81.36 µM 0.416374085675568 0.303505628041599 no 1004 0.338568144074127 341 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_820 1582-0060 59.9 µM 0.414743044526084 0.30415751401514 no 1005 0.339165008948377 360 3848840
SGTC_2157 5649910 96.377 µM 0.41414553228533 0.304396480605607 no 1006 0.33938376434399 364 2858091
SGTC_2140 5586273 200 µM 0.413662396633859 0.30458976498005 no 1007 0.339560684879345 364 854421
SGTC_158 k038-0087 26.446 µM 0.41220861113895 0.305171698797875 no 1008 0.340093263029783 360 X158
SGTC_155 k072-0202 43.6 µM 0.410104352740502 0.306014882362097 no 1009 0.340864699919523 402 5857737
SGTC_2493 resveratrol 26.09 µM 0.409319518388531 0.306329631882788 no 1010 0.341152596750241 340 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3000 9075062 71.4286 µM 0.407948554748521 0.306879785263762 no 1011 0.341655722265388 354 17057871
SGTC_2366 9070441 60.58 µM 0.406190354037865 0.307585969750244 no 1012 0.342301370502318 358 6837235
SGTC_1158 4092-0494 91.8 µM 0.405993399854388 0.307665121248865 no 1013 0.342373724976335 377 1148199
SGTC_2894 9048625 32.47 µM 0.40561340274664 0.307817858920698 no 1014 0.342513339734606 408 4092861
SGTC_1446 4239-0190 62 µM 0.40550082363589 0.307863115849402 no 1015 0.342554706565001 378 1340085
SGTC_485 niflumic acid 177 µM 0.405064163909601 0.308038681199244 no 1016 0.342715173633958 385 4488 A COX2 inhibitor.
SGTC_404 fumagillin 50 µM 0.402518805507547 0.309062952866675 no 1017 0.34365112564445 362 12015870 A methionine aminopeptidase binder.
SGTC_1612 st002233 45.4 µM 0.402295518319151 0.309152876355156 no 1018 0.343733276272229 370 1035021
SGTC_3094 9117742 49.47 µM 0.400946773591317 0.309696293512614 no 1019 0.344229656012122 370 17149698
SGTC_1891 st059073 26.2 µM 0.399621351225557 0.310230719487982 no 1020 0.344717713984305 408 688754
SGTC_2219 9098279 200 µM 0.398236252753196 0.310789636120939 no 1021 0.345228022675937 367 902349
SGTC_605 1315-0399 119 µM 0.396480035376059 0.311498935201615 no 1022 0.345875466588865 376 24020461
SGTC_2325 6158266 200 µM 0.39462011497619 0.312250881226081 no 1023 0.346561633140053 352 3623240
SGTC_2015 5119600 184 µM 0.39389592558344 0.312543875182173 no 1024 0.34682893931002 401 2828786
SGTC_108 0509-0257 621.132 µM 0.392067622454332 0.313284100645909 no 1025 0.34750412488264 370 536624
SGTC_2048 5246248 200 µM 0.389840791281077 0.314186695119925 no 1026 0.348327139162215 364 677046
SGTC_1659 st012954 42.1 µM 0.389321647319806 0.314397278200744 no 1027 0.348519112389442 373 24207262
SGTC_3297 9117502 71.43 µM 0.388876416718755 0.314577927544785 no 1028 0.348683784252323 349 7453720
SGTC_3199 9111318 49.47 µM 0.38792060989634 0.314965889704411 no 1029 0.349037392818447 381 8548020
SGTC_2080 5212524 12.4 µM 0.387561744094872 0.315111606160639 no 1030 0.349170192037792 382 260183
SGTC_2298 7976326 193.81 µM 0.386580196571672 0.315510307726326 no 1031 0.349533510550905 364 2235818
SGTC_2505 galangin 7.89 µM 0.386340242108108 0.315607809189291 no 1032 0.349622350363039 414 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3026 9090633 49.47 µM 0.38511918266179 0.316104164918975 no 1033 0.350074558189817 365 25236842
SGTC_3011 9081274 71.4286 µM 0.38477468910199 0.316244260176512 no 1034 0.350202176618615 366 6625322
SGTC_1041 0206-0046 107 µM 0.384573930453513 0.316325914900345 no 1035 0.350276555922964 383 50494
SGTC_1851 st056236 18.9 µM 0.382346992086585 0.317232279263175 no 1036 0.351102001487986 374 5393171
SGTC_2486 5283202 22.39 µM 0.381735854322667 0.317481204573657 no 1037 0.35132865127453 376 1377751
SGTC_2090 5301565 104.445 µM 0.381632105903289 0.31752347101595 no 1038 0.351367133215294 380 2056344
SGTC_2154 5570129 200 µM 0.381478411299956 0.317586089586417 no 1039 0.351424143791409 399 673366
SGTC_2068 5226020 147 µM 0.381387907000413 0.317622965475457 no 1040 0.351457716490089 377 1810509
SGTC_2272 7805186 180 µM 0.380674130297328 0.317913856486873 no 1041 0.351722533564586 425 2956062 YPR165W RHO1
SGTC_1414 3917-0015 5.4 µM 0.380205634877687 0.318104847204063 no 1042 0.351896388375668 400 6618702
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.379983168362431 0.318195556687536 no 1043 0.351978954723395 369 688664
SGTC_2744 captopril 92.04 µM 0.379918594534411 0.318221888348709 no 1044 0.352002921997484 372 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1971 st069429 63.5 µM 0.379790636083794 0.318274069455202 no 1045 0.352050416896137 375 1246522 YGL099W LSG1
SGTC_3019 9081971 49.47 µM 0.37962774471008 0.318340501329643 no 1046 0.352110881340206 388 16451803
SGTC_3270 9137563 49.47 µM 0.379534528801387 0.318378520136565 no 1047 0.352145484290534 386 17015724
SGTC_1934 st074720 32.6 µM 0.378355980295337 0.318859364847554 no 1048 0.352583082231117 372 17250992
SGTC_3185 9108267 49.47 µM 0.376835477705942 0.31948017656606 no 1049 0.353147936816504 380 4910486
SGTC_137 0438-0332 85.389 µM 0.376530983746041 0.31960456045346 no 1050 0.353261092837837 396 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.375416371715924 0.320060045564967 no 1051 0.353675415475137 374 77254
SGTC_2384 9036245 200 µM 0.374447473022325 0.32045620556506 no 1052 0.354035714574848 377 6462766
SGTC_2953 9074162 66.49 µM 0.373798807200769 0.320721544247674 no 1053 0.354277003496618 405 16451992
SGTC_1118 chelidonine 707.474 nM 0.371778019127407 0.321548740443063 no 1054 0.355029065347768 392 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_916 4466-0038 42 nM 0.371721027316299 0.321572082522259 no 1055 0.355050283779079 399 5722064 YGL116W CDC20
SGTC_354 2783-3500 4.88 µM 0.371632666527014 0.321608273755314 no 1056 0.355083181978859 365 6740761
SGTC_2918 7977171 22.06 µM 0.371131825217112 0.321813442712824 no 1057 0.355269673985013 378 2236483
SGTC_2899 9053889 58.44 µM 0.369829725705556 0.322347100159176 no 1058 0.355754682599674 407 6470052
SGTC_2567 aureobasidin a 60 nM 0.368060747892298 0.323072691597077 no 1059 0.35641396911467 392 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1432 4049-0298 68.4 µM 0.367369771985857 0.323356296163844 no 1060 0.356671608055052 420 741646
SGTC_2076 5212012 200 µM 0.365065564951535 0.324302777595463 no 1061 0.357531232379109 391 604802
SGTC_575 k072-0246 11.9 µM 0.364213590864326 0.324653024548451 no 1062 0.357849259460887 390 6796779
SGTC_2741 miltefosine 3.04 µM 0.3597477121318 0.326491481028032 no 1063 0.359517904174503 409 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1914 st062367 72.6 µM 0.359408997971125 0.326631091411314 no 1064 0.359644572205341 389 978205
SGTC_146 3448-8650 53.125 µM 0.359191054536429 0.32672093564904 no 1065 0.359726084084477 422 2891488 YIL048W NEO1
SGTC_154 3389-1638 511.116 µM 0.358797356723361 0.326883257725029 no 1066 0.359873345108306 415 5238686
SGTC_3324 9138759 60.749 µM 0.358439442723317 0.32703085452676 no 1067 0.360007239399647 394 45595710
SGTC_2524 avocatin b 10.57 µM 0.358127299126483 0.327159598592104 no 1068 0.360124025178257 376 6710748
SGTC_1649 st011737 51.3 µM 0.358075365458662 0.327181020702529 no 1069 0.360143456969916 388 1761035
SGTC_2570 licareol 100 µM 0.355891853525474 0.328082211605416 no 1070 0.360960778431095 382 443158
SGTC_215 1287-0124 461.5 µM 0.35573725350561 0.328146056997795 no 1071 0.361018671677323 404 5560863
SGTC_3075 9116269 49.47 µM 0.355497394088499 0.328245122023389 no 1072 0.361108498409246 389 17015205 YNL244C SUI1
SGTC_465 cgp-37157 41 µM 0.355006756352422 0.328447799342459 no 1073 0.361292264827775 391 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_84 0443-0269 128.823 µM 0.353963338378589 0.328878992208835 no 1074 0.361683179270462 419 6150058
SGTC_2959 9079155 11 µM 0.353607884754968 0.329025935612444 no 1075 0.361816382249032 418 16189457
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.353326919355681 0.329142104519901 no 1076 0.361921683298896 392 4330530
SGTC_193 1273-0060 1.558 µM 0.351493750310045 0.329900457428391 no 1077 0.36260898014492 388 2847393 YHR072W ERG7
SGTC_522 1273-0010 11.6 µM 0.3496551016758 0.33066178005057 no 1078 0.363298776400369 421 5705015
SGTC_1501 4491-0275 38.4 µM 0.349352822101126 0.330787011057561 no 1079 0.363412223572734 415 5104718
SGTC_620 0109-0052 432 µM 0.348623040632327 0.331089429302909 no 1080 0.363686163897736 395 493037
SGTC_1326 1431-2094 10.8 µM 0.347984610251644 0.331354082460369 no 1081 0.363925870649417 416 616278
SGTC_3347 9188721 44.724 µM 0.34706029489689 0.331737394833614 no 1082 0.364273010877703 425 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1579 chlormadinone acetate 49.4 µM 0.346283394061584 0.332059710935999 no 1083 0.364564873575286 420 45114258 A steroidal progestin.
SGTC_1690 st023502 41.2 µM 0.34577083831489 0.332272425154915 no 1084 0.36475747127457 429 24207482
SGTC_813 k007-0158 173 µM 0.34505903553432 0.33256791791715 no 1085 0.365024994553968 401 6523916
SGTC_2829 7992743 58.44 µM 0.344559604529006 0.332775310303769 no 1086 0.36521273946497 378 16462845
SGTC_3021 9087658 49.47 µM 0.343146199337956 0.333362514365562 no 1087 0.36574423834219 405 25237042
SGTC_2985 9022375 71.43 µM 0.34138221814164 0.334095939569095 no 1088 0.366407929909744 388 4939335
SGTC_1605 st000082 49.1 µM 0.341336396718252 0.334114999585388 no 1089 0.366425175390426 413 1114022
SGTC_2243 6634756 200 µM 0.340572898673603 0.334432649436275 no 1090 0.366712567343169 349 885676
SGTC_303 1348-1668 34.2 µM 0.340202050428019 0.334586981943102 no 1091 0.366852187082938 395 5380509
SGTC_2678 equilin 100 µM 0.338249917330498 0.335399843572113 no 1092 0.367587430880861 378 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1139 k015-0024 46.9 µM 0.337990541921245 0.335507904735243 no 1093 0.367685157627869 396 2766652
SGTC_919 tnp00227 403.569 nM 0.33768220662475 0.335636381303546 no 1094 0.367801342491111 415 1269246 A methoxyflavone. YNL221C POP1
SGTC_2684 capsaicin 100 µM 0.337482025121204 0.335719802843059 no 1095 0.367876780036125 416 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2536 dehydroabietamide 32.04 µM 0.33744891959612 0.335733599672556 no 1096 0.367889256203117 392 3983547
SGTC_3292 9120825 59.784 µM 0.336483569167608 0.33613600973425 no 1097 0.368253119951969 430 24824900
SGTC_929 2805-0021 398 µM 0.336099301984164 0.336296245295706 no 1098 0.368397992387083 409 3098024
SGTC_686 1319-0111 510 µM 0.333901282329614 0.337213368326192 no 1099 0.369227026055127 426 4562600
SGTC_2309 7664088 163.95 µM 0.33349759063696 0.33738191396485 no 1100 0.369379353927592 425 704922
SGTC_2158 5657123 3.6195 µM 0.333423786909367 0.337412731347263 no 1101 0.369407205033941 424 2858827
SGTC_1861 st057647 17.4 µM 0.332718218199786 0.33770740266887 no 1102 0.369673498101453 450 688668
SGTC_801 0866-0028 10.1 µM 0.329971868658301 0.338855324919971 no 1103 0.370710609148603 378 6849771
SGTC_2740 felodipine 17.08 µM 0.32943079247146 0.339081661539501 no 1104 0.370915048235416 427 3333 L-type calcium channel blocker
SGTC_83 0170-0301 39.027 µM 0.328216719696694 0.339589729473031 no 1105 0.371373903483571 399 3089716
SGTC_3050 9093513 49.47 µM 0.328129495310904 0.339626242571966 no 1106 0.371406876733273 408 25236664
SGTC_3339 9145883 14.936 µM 0.327877036050597 0.339731933310798 no 1107 0.371502318690373 418 2030670
SGTC_2915 7971052 15.16 µM 0.327097622215235 0.34005831028405 no 1108 0.371797025092248 415 5741558
SGTC_1802 st050112 57.9 µM 0.325130842972812 0.340882425136245 no 1109 0.372541023323818 389 4662563
SGTC_1738 st035555 74 µM 0.322564708222394 0.341958822597342 no 1110 0.373512462431229 431 5331140
SGTC_3335 9143315 29.6265 µM 0.322431488352464 0.342014738528764 no 1111 0.3735629163225 382 4899691
SGTC_1415 3966-0071 78.1 µM 0.322119860660553 0.342145550511077 no 1112 0.37368094644155 417 2893185
SGTC_1784 st039334 36.3 µM 0.320612687220818 0.342778483992858 no 1113 0.374251960895264 406 3496984
SGTC_2804 7954240 19.48 µM 0.319569802965516 0.34321669906906 no 1114 0.374647234304013 384 828705
SGTC_2398 5228213 48.84 µM 0.319090252269825 0.343418274848671 no 1115 0.374829037586999 417 80771 YMR134W ERG29
SGTC_451 chloral hydrate 100 µM 0.31605534520523 0.344695007775429 no 1116 0.375980250027744 413 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2046 4110841 106 µM 0.315223808619236 0.345045130535023 no 1117 0.376295864854439 423 44119630 YMR134W ERG29
SGTC_1349 flufenamic acid 69 µM 0.314438537936334 0.345375894641311 no 1118 0.376593995138901 412 3371 A non-steroidal anti-inflammatory.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.313024069654416 0.345971981133293 no 1119 0.37713118774088 413 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2222 6885208 172.143 µM 0.312752443190731 0.346086493958576 no 1120 0.37723437441941 398 609514
SGTC_925 2064-1272 59.6 µM 0.312017801025454 0.346396276356174 no 1121 0.377513497475251 413 6815817
SGTC_1154 4088-0362 150 µM 0.311667214016963 0.346544147404565 no 1122 0.377646723551176 404 6618304
SGTC_79 0052-0007 94.094 µM 0.311121403455659 0.346774406639734 no 1123 0.377854165224149 426 2801472
SGTC_825 1988-2224 89.6 µM 0.310712750149839 0.346946840875559 no 1124 0.378009501747172 395 1180859
SGTC_1499 4480-0877 67.3 µM 0.30982387510813 0.347322017595283 no 1125 0.378347447331449 426 2861909
SGTC_2810 7959871 45.46 µM 0.309149579466006 0.347606724404538 no 1126 0.378603873065132 392 2974535
SGTC_1656 st012921 11 µM 0.309096030884189 0.347629337826725 no 1127 0.378624239176775 419 6732821
SGTC_699 0375-0592 111 µM 0.308210135683216 0.348003527615764 no 1128 0.378961220239332 396 762578
SGTC_2977 9011197 71.43 µM 0.307873447479043 0.348145778869572 no 1129 0.379089315457813 453 2704722
SGTC_2970 9090938 41.86 µM 0.307094222529608 0.348475084467269 no 1130 0.379385827567763 404 17217104
SGTC_1165 k072-0275 30.3 µM 0.307060671041662 0.348489266114039 no 1131 0.379398596236306 392 6153523 YGL055W OLE1
SGTC_1033 k072-0102 21.3 µM 0.307016437354799 0.348507963269352 no 1132 0.379415430423569 421 5965931
SGTC_1668 st014914 51.6 µM 0.306246875188545 0.348833308685209 no 1133 0.379708342269318 411 2839556
SGTC_1345 1488-0192 31.4 µM 0.305887284907803 0.348985369683986 no 1134 0.379845233709932 428 658348
SGTC_1426 4048-4480 71.7 µM 0.304909044028895 0.349399163958984 no 1135 0.380217713711149 408 14224343
SGTC_1973 st070275 50.2 µM 0.302751460343717 0.350312450666972 no 1136 0.381039638661737 409 17118334
SGTC_693 4161-2696 114 µM 0.302355273152007 0.350480247600697 no 1137 0.381190623435677 410 805759
SGTC_1980 st071811 45.7 µM 0.301242804387925 0.350951566776556 no 1138 0.381614675833107 424 4974850
SGTC_247 mechlorethamine 29.705 µM 0.299968956183885 0.351491539248274 no 1139 0.38210041759939 412 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_601 0986-0029 62.9 µM 0.298921384341092 0.35193581999484 no 1140 0.382500015164974 416 24747981
SGTC_1309 pyrazolanthrone 13.4 µM 0.298732597722634 0.352015906919311 no 1141 0.382572041373101 437 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1878 temozolomide 1 mM 0.298624705307974 0.352061679910712 no 1142 0.382613206504303 430 5394 DNA alkylating agent.
SGTC_560 2332-1943 155 µM 0.297585054730311 0.352502857908101 no 1143 0.383009941332585 410 21177716
SGTC_1900 st060200 72.8 µM 0.296523399849366 0.352953578332527 no 1144 0.383415199775859 405 688945
SGTC_2263 7948595 193.29 µM 0.295762756435705 0.353276632768775 no 1145 0.383705633601451 415 2971371
SGTC_3245 9134821 49.47 µM 0.295664951560426 0.353318179357483 no 1146 0.383742982840953 419 17014901
SGTC_784 4579-0127 173 µM 0.295274408792733 0.353484095664407 no 1147 0.383892132135133 456 1948547
SGTC_2772 vinpocetine 57.06 µM 0.294303918462263 0.353896514604973 no 1148 0.384262839339541 445 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.293567103289637 0.354209745660347 no 1149 0.384544358210131 391 6708739 YPR165W RHO1
SGTC_266 formosanin C 406 nM 0.292601703697549 0.354620300642629 no 1150 0.384913305688257 412 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1526 st051518 75 µM 0.288517026372263 0.356359253835796 no 1151 0.386475499609516 402 673993
SGTC_863 0466-0191 129 µM 0.286024252478031 0.357421964580341 no 1152 0.387429773189935 451 765160 YPR165W RHO1
SGTC_501 nsc-95397 161 µM 0.285582026754815 0.357610608528964 no 1153 0.387599135485271 433 262093
SGTC_914 3820-6779 408 µM 0.28535020386314 0.357709513073409 no 1154 0.387687926876122 385 2893481
SGTC_843 0310-0051 143 µM 0.285135244370094 0.357801231582503 no 1155 0.387770264599353 446 2065037
SGTC_230 MPP+ 141.667 µM 0.283868435778185 0.358341917685374 no 1156 0.388255603229528 418 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2756 carbadox 75.1 µM 0.283583996877086 0.358463358048116 no 1157 0.388364601242495 397 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_234 nsc-17383 10.7 µM 0.282545962643233 0.358906665115034 no 1158 0.388762454237546 410 408974
SGTC_1301 naphtanilide LB 4.81 µM 0.282162615343866 0.35907042704904 no 1159 0.388909411359091 427 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_632 0781-2353 4.65 µM 0.281628244238277 0.359298747975336 no 1160 0.389114290344766 430 6811515 YHR007C ERG11
SGTC_726 3448-4391 34.2 µM 0.281064399462044 0.359539716614437 no 1161 0.389330503028977 423 1356692
SGTC_1968 st069590 43.6 µM 0.280351064217387 0.359844652576672 no 1162 0.389604088622929 430 6384066
SGTC_1602 st001878 87.6 µM 0.27979463262768 0.360082577455702 no 1163 0.389817534924962 451 595405 YLR310C CDC25
SGTC_834 0312-0008 75.7 µM 0.279317254742086 0.36028674292986 no 1164 0.390000682836373 419 6385573 YIL048W NEO1
SGTC_2721 ifenprodil 61.44 µM 0.279210229895025 0.360332520899012 no 1165 0.390041746694507 415 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1871 st057448 67.3 µM 0.277867883957567 0.360906855288681 no 1166 0.390556889140344 449 691747
SGTC_1803 st050068 52.4 µM 0.277062408315616 0.361251635776175 no 1167 0.390866093046791 429 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2716 st080858 38.6235 µM 0.277061506864004 0.361252021701979 no 1168 0.3908664391324 416 5296050
SGTC_1372 2752-0194 270 µM 0.276886773424992 0.361326830538532 no 1169 0.390933524485499 422 823334
SGTC_1648 st011736 69.8 µM 0.275952094849373 0.36172708558094 no 1170 0.391292430401667 418 2855514
SGTC_700 3453-2283 142 µM 0.275905398565932 0.361747086184724 no 1171 0.391310363672761 402 565664
SGTC_1951 sophoraflavanone G 9.2 µM 0.274570815060192 0.362318864484212 no 1172 0.391822995515433 417 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3230 9131665 49.47 µM 0.274075247138041 0.362531259956208 no 1173 0.39201339783731 444 15943720
SGTC_3152 9099253 49.47 µM 0.273462339532013 0.362794004571517 no 1174 0.392248919048119 429 25236131
SGTC_1680 diphenhydramine 100 µM 0.27062906525877 0.364009426162836 no 1175 0.393338169449872 444 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_11 0438-0307 1.3 µM 0.27009792169213 0.364237429579188 no 1176 0.393542460481257 429 4011476
SGTC_1834 st055981 52.8 µM 0.270033357887242 0.364265148090244 no 1177 0.393567295326065 444 471719 YDL150W RPC53
SGTC_2349 9023730 187.07 µM 0.269773288839031 0.364376808035004 no 1178 0.39366733678886 418 4126287
SGTC_2583 asiatic acid 100 µM 0.269342105174022 0.364561960937634 no 1179 0.393833216836048 469 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1324 1418-0026 34.4 µM 0.268891410092708 0.364755525939843 no 1180 0.394006623684821 409 1372513
SGTC_2250 alverine citrate 130 µM 0.268853758587257 0.364771698109624 no 1181 0.394021111213269 412 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_3326 9140064 16.379 µM 0.26756742885913 0.365324350064034 no 1182 0.394516152522305 419 1868434
SGTC_2244 6635614 200 µM 0.267538534872026 0.365336767141978 no 1183 0.39452727427266 406 836499
SGTC_3097 9117246 49.47 µM 0.267107182470767 0.365522155926484 no 1184 0.394693318817799 397 16423892
SGTC_883 0850-0245 24.6 µM 0.266672857169182 0.365708854164908 no 1185 0.394860527079967 436 6823229 YPR165W RHO1
SGTC_2552 juarezic acid 87.02 µM 0.265934435740484 0.366026343583035 no 1186 0.395144851904474 401 1549512
SGTC_167 3672-0051 66.205 µM 0.265426302673115 0.366244872231943 no 1187 0.395340537992659 432 3237971
SGTC_1675 st018485 24.5 µM 0.263939091556338 0.366884714083702 no 1188 0.395913426331945 415 3323024
SGTC_1404 3909-7820 48.3 µM 0.263798087103849 0.366945397565776 no 1189 0.395967754324872 432 23741373
SGTC_2738 aclarubicin 5.55 µM 0.263500440090473 0.367073505550765 no 1190 0.396082442194573 423 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_645 0845-0943 5.41 µM 0.263446040273022 0.367096920962309 no 1191 0.396103404234736 418 1885106
SGTC_1588 farnesol 29.9 µM 0.262225009932047 0.36762262118151 no 1192 0.396573986351866 417 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3305 9127027 53.8275 µM 0.260576406447835 0.368332801521865 no 1193 0.397209593087239 416 41905295
SGTC_1716 st033144 30.6155 µM 0.260516155692794 0.368358764696649 no 1194 0.39723282749768 455 674617
SGTC_1454 4239-0054 42.6 µM 0.259867407238374 0.368638360573334 no 1195 0.397483026502617 456 1340767
SGTC_2204 7233102 200 µM 0.259811768121108 0.368662343012004 no 1196 0.397504486479561 436 2172480
SGTC_1608 st001473 40.5 µM 0.258735784349336 0.369126230786101 no 1197 0.397919553762598 458 7292267
SGTC_1004 4084-0029 199 µM 0.258054218072173 0.369420172438552 no 1198 0.398182531915182 451 716894 YLR208W SEC13
SGTC_2433 5607874 27.82 µM 0.255636823430327 0.37046334587818 no 1199 0.399115640963768 442 2252428
SGTC_410 α-linolenic acid 100 µM 0.255331856216718 0.370595015637261 no 1200 0.399233398721487 456 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3262 9137218 49.47 µM 0.253975073595648 0.371180990813672 no 1201 0.399757407615594 427 17650664
SGTC_1250 0485-0349 40.2 µM 0.253880723471524 0.371221750420428 no 1202 0.399793853712247 424 6842794 YDL195W SEC31
SGTC_135 0933-0004 26.348 µM 0.25361948887119 0.371334612280675 no 1203 0.399894769437126 456 21230617 YGL099W LSG1
SGTC_2400 5203494 178.7 µM 0.253203337222613 0.371514426202663 no 1204 0.400055543898462 421 6777674
SGTC_2127 5253358 187.912 µM 0.252443571452319 0.371842783795687 no 1205 0.400349112627854 432 20612
SGTC_42 0133-0086 60.653 µM 0.25096398798561 0.372482501532221 no 1206 0.400920975867194 474 162923 Model of phenazepam hydroxylation.
SGTC_2523 spermine 47.74 µM 0.25063124692562 0.37262641512807 no 1207 0.401049610531889 433 1103 A DNA binding polyamine.
SGTC_2453 5731132 22.18 µM 0.248584019972951 0.373512250386674 no 1208 0.401841285384662 434 1362040
SGTC_1059 3448-6867 171 µM 0.248350725312621 0.373613239538876 no 1209 0.401931527455737 447 3934407
SGTC_1785 bathophenanthroline 24 µM 0.246694072421811 0.374330624690702 no 1210 0.402572497168265 407 72812 An iron chelator.
SGTC_1791 st048313 56.1 µM 0.245453449350735 0.374868140476366 no 1211 0.403052673919434 433 1204976
SGTC_854 0422-0053 192 µM 0.242877194497879 0.3759851114985 no 1212 0.404050266413568 434 3596728
SGTC_1590 st077108 57.8 µM 0.242298704425481 0.376236067179393 no 1213 0.404274358794702 449 5489485
SGTC_3265 9137266 49.47 µM 0.240612893575304 0.376967689545245 no 1214 0.404927578055576 428 17224265
SGTC_2220 6782180 200 µM 0.239987992270367 0.37723900188914 no 1215 0.405169782704427 441 833803
SGTC_2906 7926292 26.41 µM 0.239704462384563 0.377362121576962 no 1216 0.405279687653418 453 2966319
SGTC_34 0469-0683 81.75 µM 0.239504012140958 0.377449172380104 no 1217 0.405357392872466 423 3690923
SGTC_741 4582-0002 126 µM 0.239310185402267 0.377533352672949 no 1218 0.405432534015068 443 2912688
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.238381575093328 0.377936735194109 no 1219 0.405792578262264 467 368090
SGTC_2436 5633522 8.09 µM 0.238361000561667 0.377945674151272 no 1220 0.405800556399979 424 5724242
SGTC_321 4534-3890 65.3 µM 0.238077589120842 0.378068813747048 no 1221 0.405910458167442 452 699746
SGTC_1323 1348-1351 11.2 µM 0.236340196218114 0.37882396487781 no 1222 0.406584349085749 460 6989654
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.234084634205221 0.379805026338464 no 1223 0.407459637349996 463 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_441 propafenone 146 µM 0.233342279960062 0.380128084514291 no 1224 0.407747814963518 455 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2687 chenodiol 100 µM 0.232427933520867 0.380526105307946 no 1225 0.408102827546312 422 5702181 A cholesterol synthesis inhibitor.
SGTC_1525 8-methoxypsoralen 92.5 µM 0.231999670995821 0.38071257422594 no 1226 0.40826913466946 475 4114 Related to psoralen; DNA damaging agent.
SGTC_2492 derrusnin 100 µM 0.229943864344573 0.381608073946835 no 1227 0.409067695305571 461 1715307 Part of coumarin class of compounds.
SGTC_1311 1190-0148 100 µM 0.229379214454359 0.381854143981384 no 1228 0.409287094991997 446 1961333
SGTC_1121 fusaric acid 630.51 nM 0.228984348012243 0.382026252082809 no 1229 0.409440540714124 411 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3356 9151811 4.48 µM 0.228535248337256 0.382222026841737 no 1230 0.409615078419089 468 1859254 YPR165W RHO1
SGTC_27 0485-0001 32.618 µM 0.228172162154067 0.382380327998828 no 1231 0.409756201013931 471 2054479
SGTC_1845 st056753 3.01 µM 0.227963005795522 0.382471526551518 no 1232 0.40983750021202 426 5375839
SGTC_2322 7413319 38.22 µM 0.227919406864291 0.382490537836756 no 1233 0.409854447630276 442 1840400
SGTC_3182 9108849 49.47 µM 0.227364539941172 0.382732511916358 no 1234 0.410070145640246 425 17133045
SGTC_1241 0364-0022 50.8 µM 0.227336854187089 0.382744586704712 no 1235 0.410080908865826 448 4563895
SGTC_2754 granisetron 64.02 µM 0.226777214054577 0.382988691028729 no 1236 0.410298491338354 461 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1160 4092-0570 10.5 µM 0.226401073382462 0.38315278252009 no 1237 0.410444746582454 452 4994975
SGTC_288 1315-0019 35.1 µM 0.226019160125652 0.383319413756761 no 1238 0.410593259131343 452 6811474
SGTC_3233 9132340 49.47 µM 0.223737375344529 0.384315420080065 no 1239 0.411480830876447 468 17682950
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.222788412532419 0.384729870787396 no 1240 0.41185009341686 438 6708514
SGTC_1753 st043925 64 µM 0.222097319102568 0.38503178238327 no 1241 0.4121190623971 450 670181
SGTC_3343 9148379 18.9835 µM 0.221382310377948 0.385344215004846 no 1242 0.412397382505049 450 1955036
SGTC_2782 7736369 71.43 µM 0.219905578826193 0.385989727994496 no 1243 0.412972345693612 439 2950836 YOL077C BRX1
SGTC_1302 1159-0335 255 µM 0.21819537161777 0.386737693052383 no 1244 0.413638445562177 436 649284
SGTC_3178 9107506 49.47 µM 0.217901017754393 0.386866472269824 no 1245 0.413753117073332 444 8897194
SGTC_1959 st077091 55.8 µM 0.217723451981354 0.386944162959436 no 1246 0.413822294975122 454 821356 YKL052C ASK1
SGTC_935 2996-0153 430 µM 0.21763429807801 0.386983172344354 no 1247 0.413857029479227 465 23738523
SGTC_2886 9058944 51.95 µM 0.215880494532074 0.387750782591351 no 1248 0.414540450858877 445 4949929
SGTC_1776 st049249 45.9 µM 0.214680095439864 0.388276430246452 no 1249 0.415008371150403 420 1822314
SGTC_1765 st044815 90.4 µM 0.21356829789794 0.388763462445005 no 1250 0.415441861798717 449 645695
SGTC_2825 7998094 58.44 µM 0.213245008685719 0.388905114838846 no 1251 0.415567931832886 462 2987815
SGTC_768 0384-0033 77.3 µM 0.212695343188264 0.389145990156388 no 1252 0.415782299629085 435 3965305 YMR134W ERG29
SGTC_649 1123-0311 367 µM 0.212604966365994 0.389185599317271 no 1253 0.415817548703318 456 693629 YIL048W NEO1
SGTC_2790 5423970 71.43 µM 0.211764739265765 0.38955389802896 no 1254 0.41614528930453 431 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2965 9082772 38.63 µM 0.21155853438837 0.389644299470478 no 1255 0.416225730897335 419 16459634
SGTC_2254 7938975 95.19 µM 0.210472381928527 0.390120573605447 no 1256 0.416649502456834 442 2969277
SGTC_2544 sphondin 68.51 µM 0.210020097055443 0.390318947670157 no 1257 0.416825993821458 469 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.209899794948627 0.390371717495477 no 1258 0.416872941136321 451 66535 A nucleotide analog.
SGTC_3010 9080089 71.4286 µM 0.209530176163877 0.390533861275324 no 1259 0.417017190491726 440 17027233
SGTC_541 4513-1321 94 µM 0.20901800624565 0.390758570623033 no 1260 0.417217091058191 424 747515
SGTC_2860 9025725 38.96 µM 0.207899013075445 0.391249644346294 no 1261 0.41765390989435 474 40546248
SGTC_2110 5483698 200 µM 0.207281314650503 0.391520797604894 no 1262 0.417895083002408 426 2848765 YHR062C RPP1
SGTC_3035 9091303 49.47 µM 0.206371458030221 0.391920296560106 no 1263 0.418250382071763 467 25237002
SGTC_1904 st060225 78 µM 0.206343907504752 0.391932395197864 no 1264 0.418261141595903 443 66595
SGTC_3076 9116187 49.47 µM 0.204479138479111 0.392751538968173 no 1265 0.418989546338417 463 27241210
SGTC_36 0335-0881 14.2 µM 0.203604970473322 0.393135701718272 no 1266 0.419331104316636 444 23828853
SGTC_2928 9011484 9.79 µM 0.201606829916336 0.394014196897445 no 1267 0.420112052684564 456 2994751
SGTC_1725 st036284 20.55 µM 0.200208501367237 0.394629302120329 no 1268 0.420658759325095 425 707914
SGTC_100 0086-0128 49.5915 µM 0.19974255424456 0.394834324208787 no 1269 0.420840965433355 459 93297
SGTC_1300 1094-0077 113 µM 0.19864783239101 0.39531612891397 no 1270 0.421269117167284 441 5532636
SGTC_2165 5727197 32.143 µM 0.198074757752805 0.39556841216234 no 1271 0.421493286971416 457 1361712
SGTC_3101 9120531 49.47 µM 0.197518851836165 0.395813179087158 no 1272 0.421710765196658 482 24824904
SGTC_2685 mycophenolic acid 18.85 µM 0.19695771736295 0.396060289833256 no 1273 0.421930313125481 466 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_416 estradiol valerate 100 µM 0.196356262299647 0.396325203223921 no 1274 0.422165663719396 446 13791 A steroid.
SGTC_1120 ficusin 1.78878 µM 0.196265877179942 0.39636501786764 no 1275 0.422201034005682 448 6199 A DNA cross-linker.
SGTC_341 1486-1430 230 µM 0.19618700364001 0.396399762543775 no 1276 0.422231899993757 461 2054753 YPL210C SRP72
SGTC_1419 3993-2473 62.6 µM 0.195550473079299 0.396680191462818 no 1277 0.422481014237076 455 704026
SGTC_580 1123-0028 41 µM 0.194564830330253 0.3971145301167 no 1278 0.422866819078552 477 1677248 YPR107C YTH1
SGTC_2967 9089538 49.85 µM 0.19404592107019 0.397343246793437 no 1279 0.423069962694832 459 728216
SGTC_94 0334-0113 514.748 µM 0.192087043181033 0.398206967789601 no 1280 0.423837011984597 480 6795178
SGTC_709 3807-1509 243 µM 0.19172116548505 0.398368348361536 no 1281 0.423980312937192 472 1886677 YPL242C IQG1
SGTC_2442 5158906 48.48 µM 0.191661731532145 0.398394565007653 no 1282 0.424003591999 474 1893835
SGTC_1883 5-benzylidenerhodanine 20 µM 0.190585545653934 0.398869355786799 no 1283 0.424425157756154 462 1273210
SGTC_1389 3405-0187 19 µM 0.189400318326109 0.399392426565698 no 1284 0.424889537497818 478 799890
SGTC_1184 1269-1718 139 µM 0.189395675420188 0.399394475953275 no 1285 0.424891356823835 443 5403821
SGTC_1943 st076331 65.2 µM 0.188980421435463 0.39957778106419 no 1286 0.425054080861481 482 24208415
SGTC_120 rhodamine 6G 52.259 µM 0.188720704358599 0.399692438943823 no 1287 0.425155861721321 483 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1174 0739-0097 51.1 µM 0.18869483292838 0.39970386093599 no 1288 0.425166000782778 460 728447
SGTC_563 tetrahydrosecaminediol 614 µM 0.188557636313047 0.399764433380438 no 1289 0.425219769217686 438 334274 A psychoactive constituent of the cannabis plant.
SGTC_1406 3909-7906 11.9 µM 0.18841416019502 0.399827780812043 no 1290 0.425276000127112 471 X1406
SGTC_526 4469-0568 170 µM 0.188233397627478 0.399907594672538 no 1291 0.425346846440534 442 2901964
SGTC_57 miconazole 162.5 nM 0.186577229996708 0.400639052799467 no 1292 0.425996060529101 468 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3179 9107801 49.47 µM 0.184783320827102 0.401431738645956 no 1293 0.426699495310412 406 4818259
SGTC_2462 5162487 171.77 µM 0.184660871831806 0.401485860780313 no 1294 0.426747519023813 472 2259986
SGTC_2705 st078069 42.8 µM 0.182748362604129 0.402331429490293 no 1295 0.427497733412271 449 1530061
SGTC_2360 9040895 200 µM 0.181989671762659 0.402666992790792 no 1296 0.427795415645261 431 4914414
SGTC_2312 7706453 155.7 µM 0.180921192379135 0.403139694826511 no 1297 0.428214717116793 460 976098
SGTC_1792 st045773 43.6 µM 0.180872435847774 0.403161268407172 no 1298 0.428233852493455 459 2919270
SGTC_262 fenpropimorph 62.5 µM 0.180262055426303 0.403431371837793 no 1299 0.428473421521162 476 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2372 9071633 200 µM 0.179372980757726 0.403824884476627 no 1300 0.428822422765856 477 21321366
SGTC_2175 5807670 165.306 µM 0.177876552204546 0.404487437200764 no 1301 0.429409962899581 457 241186
SGTC_882 0843-0131 351 µM 0.177427208604619 0.40468644035253 no 1302 0.429586418486829 471 5425421
SGTC_427 1354-0053 47.3 µM 0.176176456536443 0.405240497149032 no 1303 0.43007765822 444 6813657
SGTC_879 0831-1030 162 µM 0.173490566362559 0.406430930490083 no 1304 0.431132921199938 479 1549252
SGTC_1626 st003712 1.76 µM 0.173071480951983 0.406616754773214 no 1305 0.43129762077319 465 24207035
SGTC_971 1315-0384 26.7 µM 0.171947680366212 0.407115156510123 no 1306 0.431739330631756 470 6769120
SGTC_2171 5739187 198.077 µM 0.171596809582009 0.407270797364922 no 1307 0.431877257917206 468 2262761
SGTC_1611 st001856 99.4 µM 0.171357141060621 0.407377119033345 no 1308 0.431971476374125 484 647478
SGTC_2739 tacrine 100.86 µM 0.168839396786219 0.40849445084457 no 1309 0.432961484499157 472 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1607 st000305 50.6 µM 0.167918454387673 0.408903335707461 no 1310 0.433323715884322 480 5457690
SGTC_2865 9030313 51.95 µM 0.167742065012839 0.408981661320576 no 1311 0.433393100965507 481 42562754
SGTC_1698 5-fluorocytosine 1.055 µM 0.167082188448202 0.409274711384998 no 1312 0.433652690282796 477 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2195 6536160 144.242 µM 0.166628719067158 0.409476125776176 no 1313 0.433831097529084 449 3834386
SGTC_679 0422-0091 41.4 µM 0.166394279556617 0.409580264542767 no 1314 0.433923337727652 485 627384 YHR062C RPP1
SGTC_3218 9131285 49.47 µM 0.164811320228242 0.410283586662188 no 1315 0.434546246819645 486 17156417
SGTC_435 c-PAF 6.7 µM 0.164491115294638 0.410425891577041 no 1316 0.434672270226604 486 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1506 4226-2149 212 µM 0.164442521420221 0.410447488612667 no 1317 0.434691395951492 467 991114
SGTC_2513 baicalein 25.65 µM 0.163173170892841 0.411011734093986 no 1318 0.435191044800202 475 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2690 usnic acid 100 µM 0.162955847753338 0.411108356008437 no 1319 0.435276599147576 474 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1591 genipin 88.4 µM 0.160774291416448 0.412078574260774 no 1320 0.436135587137468 481 442424 A DNA cross-linking agent.
SGTC_2576 guaiol 23.12 µM 0.159915124331964 0.412460825327404 no 1321 0.436473967175825 442 227829
SGTC_1447 4239-0816 81.9 µM 0.159344332811188 0.412714821480433 no 1322 0.436698797197832 453 1341554
SGTC_791 1348-1292 225 µM 0.158874068908148 0.412924111380417 no 1323 0.436884045596851 491 5437054
SGTC_377 3970-0964 33.1 µM 0.15842330634705 0.413124745487213 no 1324 0.437061624934958 469 16481235
SGTC_1303 1160-0052 261 µM 0.157861668660715 0.413374761781413 no 1325 0.437282901619908 485 3562476
SGTC_1107 amlodipine 47 µM 0.157404867708882 0.41357813530184 no 1326 0.437462888701024 475 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3080 9117754 49.47 µM 0.156408907581807 0.414021629573203 no 1327 0.437855358176423 480 9550191
SGTC_2024 5144227 134 µM 0.156333099127727 0.414055391060822 no 1328 0.437885233873378 465 3475211
SGTC_256 clotrimazole 625 nM 0.15615925596908 0.414132814951152 no 1329 0.437953745847672 472 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2321 7390090 138.78 µM 0.156158761779815 0.414133035051172 no 1330 0.437953940611409 465 649046
SGTC_2663 amphotericin b 100 µM 0.15595459180751 0.414223969755565 no 1331 0.438034406831199 470 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2180 6301957 200 µM 0.155608907141221 0.414377943783145 no 1332 0.438170651795773 469 845462
SGTC_1418 3966-3099 2.4 µM 0.155404371252729 0.414469053861667 no 1333 0.438251269135673 486 740335
SGTC_302 1094-0063 18.9 µM 0.154364281933235 0.414932430551028 no 1334 0.43866125747477 480 5440289
SGTC_124 0136-0217 7.121 µM 0.153453179816084 0.41533843863689 no 1335 0.43902045500791 457 3976905
SGTC_1283 0922-0125 16.4 µM 0.153317389569667 0.415398957650369 no 1336 0.439073993952892 473 3360884
SGTC_1434 4073-0095 163 µM 0.153282948609824 0.415414307620668 no 1337 0.439087573401866 486 24133745
SGTC_2457 5731572 11.68 µM 0.151366951282299 0.416268449995897 no 1338 0.439843129049658 484 2865357
SGTC_1662 st014054 52 µM 0.151063659158124 0.416403692531767 no 1339 0.439962749626756 480 2838777
SGTC_748 act1.228 77.9 µM 0.150546444508098 0.416634349173 no 1340 0.440166755410722 446 4421505 YNR035C ARC35
SGTC_1355 1499-0035 1.68 µM 0.149666393908009 0.417026881786078 no 1341 0.440513911628037 473 1548538
SGTC_353 1988-1175 58.3 µM 0.149564699206633 0.417072246434282 no 1342 0.440554030396314 471 2788357
SGTC_3015 9080845 49.47 µM 0.149303121514999 0.417188937820311 no 1343 0.440657226134603 488 5296973
SGTC_1086 cerivastatin 2.18 µM 0.149265340500151 0.417205792762073 no 1344 0.440672131560483 476 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2025 5147754 141 µM 0.149157013682344 0.417254120581725 no 1345 0.440714869294351 488 315777 YLR208W SEC13
SGTC_313 3474-0040 5.03 µM 0.14746742611079 0.418008057281964 no 1346 0.441381544401031 486 1043375 YIL048W NEO1
SGTC_744 1594-0068 283 µM 0.147304272298861 0.418080876640763 no 1347 0.441445930229803 448 668392
SGTC_855 0428-0020 25 µM 0.146519421670961 0.418431213021592 no 1348 0.44175567954604 458 6812414
SGTC_2455 5377712 9.75 µM 0.146430996391351 0.418470687768712 no 1349 0.441790579721972 485 2243908
SGTC_1739 st037196 92.5 µM 0.146147506254143 0.418597248757593 no 1350 0.441902472214724 470 612214
SGTC_830 4076-0286 57.8 µM 0.145093611477611 0.419067822041327 no 1351 0.442318481108591 472 6866659
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.144791115007807 0.419202910793724 no 1352 0.442437898748272 472 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_337 1315-0038 354 µM 0.14446167884816 0.419350041097 no 1353 0.44256795741758 498 1626437
SGTC_1429 4049-0205 9.46 µM 0.144449841323366 0.419355328093428 no 1354 0.442572630889683 459 22774478
SGTC_1225 1216-0074 20.6 µM 0.144335279828092 0.419406495472638 no 1355 0.442617860348394 477 4241466
SGTC_2218 6965428 192.983 µM 0.144171252800842 0.419479758350936 no 1356 0.442682620351569 466 675684
SGTC_547 1120-0019 610 nM 0.143432837905908 0.419809606826308 no 1357 0.442974175094438 476 3676939
SGTC_652 0437-0092 114 µM 0.143431566573226 0.419810174776759 no 1358 0.442974677092397 459 3091274
SGTC_710 3448-4187 58 µM 0.141309529524153 0.420758397655842 no 1359 0.443812710843143 462 3946412
SGTC_2262 9014885 67.46 µM 0.141181408066625 0.420815662940944 no 1360 0.443863316584016 494 6457424
SGTC_1025 k007-0731 70 µM 0.140852218474577 0.420962805505843 no 1361 0.443993344926262 488 6256118
SGTC_2718 lomofungin 53.02 µM 0.139183693030555 0.421708779506434 no 1362 0.444652497075499 485 5351222 A RNA synthesis inhibitor.
SGTC_1530 rhein 70.4 µM 0.13908721957666 0.421751920035994 no 1363 0.444690613680353 495 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1908 st060353 56.5 µM 0.138776540819835 0.421890854229456 no 1364 0.444813366148216 481 4227716
SGTC_530 4358-1714 28 µM 0.137984284365423 0.422245191850287 no 1365 0.445126418995461 492 1564641
SGTC_2828 7998861 71.43 µM 0.13760166179535 0.422416342797078 no 1366 0.445277621050573 489 2988188
SGTC_1149 3909-7961 23.3 µM 0.137014958551707 0.422678809537271 no 1367 0.44550948570405 494 735261
SGTC_2166 5933061 31.504 µM 0.136485515027082 0.422915690122034 no 1368 0.445718737364195 465 2877375
SGTC_3051 9093778 49.47 µM 0.133355707232754 0.424316577402976 no 1369 0.446956036484825 492 17217378
SGTC_612 0302-0167 22.4 µM 0.132701995101574 0.424609297253518 no 1370 0.447214532479631 472 235821
SGTC_2176 5809774 33.9695 µM 0.132438926481413 0.424727106117822 no 1371 0.447318563477559 510 2870539
SGTC_852 0418-0143 439 µM 0.132318975892988 0.424780825295343 no 1372 0.447365999374794 484 5369229
SGTC_3259 9138485 49.47 µM 0.132282993121585 0.42479694024391 no 1373 0.447380229339662 438 17646153
SGTC_2884 9058502 51.95 µM 0.129369143870883 0.426102327702957 no 1374 0.448532781049756 480 6471554
SGTC_2800 7887935 81.82 µM 0.128725363485777 0.426390847327302 no 1375 0.448787482609038 475 2961002
SGTC_1995 st072814 61.1 µM 0.128710766464279 0.426397389653999 no 1376 0.448793257935573 467 5769371
SGTC_973 1325-0077 65.9 µM 0.128228948238042 0.42661335001452 no 1377 0.448983895894077 497 2835149
SGTC_2299 7976368 114.88 µM 0.128152319266477 0.426647698649229 no 1378 0.449014216279465 469 2979718
SGTC_3133 9127736 49.47 µM 0.127764413448859 0.42682158443473 no 1379 0.449167706577635 481 27243420
SGTC_1050 3232-1156 69.3 µM 0.127420322538009 0.4269758413018 no 1380 0.449303866140442 499 700529
SGTC_1189 1431-2119 7.28 µM 0.127285768597863 0.427036165228391 no 1381 0.449357111849889 503 3107275
SGTC_2843 9000894 45.46 µM 0.126650095475882 0.427321176578543 no 1382 0.44960867284726 473 2242070
SGTC_604 1000-0114 314 µM 0.126321541051984 0.427468502611863 no 1383 0.449738702773971 483 1572745
SGTC_2355 9061122 103.12 µM 0.125782261156783 0.427710341293957 no 1384 0.449952141893206 492 5302957
SGTC_3177 9107506 49.47 µM 0.125642205169159 0.42777315348815 no 1385 0.450007576381779 501 8897194
SGTC_1691 st019933 84.6 µM 0.125180966851382 0.427980022201737 no 1386 0.450190142480613 499 6176082
SGTC_3161 9100388 49.47 µM 0.124543402868235 0.428266006832619 no 1387 0.450442518673997 491 25236368
SGTC_1204 4049-0315 18.3 µM 0.123803112403484 0.428598117547111 no 1388 0.450735583717094 450 588402
SGTC_1737 st035557 69.7 µM 0.122514693532664 0.429176251277241 no 1389 0.451245704947957 508 5716916
SGTC_2541 muurolladie-3-one 83.07 µM 0.122188443094172 0.429322669119816 no 1390 0.451374889473387 495 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2839 9003951 25.97 µM 0.121442767823086 0.429657356995567 no 1391 0.451670171858187 500 2990634
SGTC_2792 7535235 81.82 µM 0.121384092630237 0.429683694838371 no 1392 0.45169340797633 472 1281891
SGTC_1799 st045822 46.1415 µM 0.119524263742215 0.430518687591323 no 1393 0.452430009068723 499 3674992
SGTC_2916 7875993 68.79 µM 0.118670994051092 0.430901877593093 no 1394 0.452768008759153 498 1299250
SGTC_19 0279-0214 38.434 µM 0.118361414645407 0.43104092093963 no 1395 0.452890648735035 502 3566274 YBR002C RER2
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.11737543123881 0.431483818751594 no 1396 0.453281276254281 478 88881 An O-methylated flavonoid and antioxidant.
SGTC_603 3794-0023 45.9 µM 0.116068483520164 0.432071024499483 no 1397 0.453799133232709 478 3802260
SGTC_334 1502-1024 68.5 µM 0.115768186587516 0.432205967817835 no 1398 0.453918132185563 495 3296216
SGTC_2553 4-methylesculetin 85.09 µM 0.114770125771725 0.432654519444716 no 1399 0.454313664365374 453 5319502
SGTC_2746 daunorubicin 9.88 µM 0.112684137840567 0.433592290320742 no 1400 0.455140488656848 496 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2689 tacrolimus 100 µM 0.111085052162769 0.43431142429501 no 1401 0.455774451010639 508 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_576 1073-0113 22.7 µM 0.10944178427259 0.435050654216763 no 1402 0.456426046854995 502 5439563
SGTC_3148 9097893 49.47 µM 0.10880888407278 0.435335427340937 no 1403 0.456677038594565 496 17174100
SGTC_1790 st045711 43.5 µM 0.106278492002832 0.436474309635706 no 1404 0.457680697913351 495 585119
SGTC_3290 9121031 71.43 µM 0.105746612324284 0.436713766083862 no 1405 0.457891698184839 503 17014854
SGTC_983 1491-0821 12.2 µM 0.105650934609831 0.436756843413108 no 1406 0.457929655443461 486 46495113
SGTC_3160 9100216 49.47 µM 0.105248802724825 0.43693790492472 no 1407 0.458089193378263 509 17191039
SGTC_3338 9144300 39.5675 µM 0.103173782091841 0.437872400513759 no 1408 0.458912523852885 484 4901274
SGTC_3248 9135562 49.47 µM 0.102381800367757 0.438229164992124 no 1409 0.459226814479293 467 17650701
SGTC_90 0870-0863 4.608 µM 0.102124202570471 0.43834521606023 no 1410 0.459329045286138 510 1738164
SGTC_778 3456-2434 196 µM 0.101563546612654 0.438597816979659 no 1411 0.459551557683362 498 5539063
SGTC_411 enrofloxacin 100 µM 0.101346031216821 0.438695824264301 no 1412 0.459637888322116 507 71188 A bacterial gyrase inhibitor.
SGTC_1744 st037937 38.9 µM 0.100886014896652 0.43890310909543 no 1413 0.459820472479027 479 1016152
SGTC_2910 7948405 25.97 µM 0.10077196533807 0.438954502787274 no 1414 0.459865740973396 510 2971328
SGTC_824 1304-0008 100 µM 0.100346587619431 0.43914619810116 no 1415 0.460034586271397 489 768245
SGTC_423 5-fluorouracil 457 µM 0.100270279633463 0.439180587598963 no 1416 0.46006487598512 505 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1831 st055328 12 µM 0.0998993727635905 0.439347749651504 no 1417 0.460212107161717 500 1103068
SGTC_2339 9000433 200 µM 0.0996510874940912 0.439459654069789 no 1418 0.460310666844505 497 2988954
SGTC_3229 9132204 49.47 µM 0.0994303775796203 0.439559134087989 no 1419 0.460398282221688 508 17682924
SGTC_1245 0418-0076 17.2 µM 0.099078182008959 0.439717886203643 no 1420 0.460538097537006 503 6790114
SGTC_195 4234-0266 16.654 µM 0.0979258973051067 0.44023734601656 no 1421 0.46099556786949 517 2303354
SGTC_293 4049-0273 38.5 µM 0.0968906979458448 0.440704110511823 no 1422 0.461406598007024 483 1380311
SGTC_71 0417-1750 47.813 µM 0.0967725047538393 0.44075740828772 no 1423 0.461453529727648 520 6811472
SGTC_1693 xanthone 101.9 µM 0.096128600235887 0.441047787987324 no 1424 0.461709218391161 509 7020 An insecticide.
SGTC_2376 9072922 81.32 µM 0.0960345793690763 0.441090190952917 no 1425 0.461746554554201 501 17087968
SGTC_940 3232-1287 54.8 µM 0.0958477667885581 0.441174444545421 no 1426 0.461820739777398 503 1585493 YIL048W NEO1
SGTC_309 k408-0051 1.48 µM 0.0955347730194531 0.441315612574892 no 1427 0.461945035841874 519 3640463
SGTC_183 3914-0051 30.55 µM 0.0955265961550257 0.441319300645571 no 1428 0.461948283087594 502 1596232
SGTC_375 3970-0961 9.27 µM 0.0944522894479917 0.441803897151364 no 1429 0.462374940223739 491 2898222
SGTC_643 k048-0106 28.4 µM 0.0939893214186697 0.442012758913401 no 1430 0.462558819728639 516 6763920
SGTC_2002 4023503 131 µM 0.0925881763050868 0.442644964567245 no 1431 0.46311536866896 507 4736863 YCR052W RSC6
SGTC_651 3253-0966 34.4 µM 0.0925458572386336 0.442664061481877 no 1432 0.463132179356857 487 781462
SGTC_722 3534-0461 190 µM 0.0923843117958193 0.44273696175139 no 1433 0.463196351746642 489 658262
SGTC_1658 st012944 20 µM 0.092088653010555 0.442870388084125 no 1434 0.463313801864637 505 24207260
SGTC_2402 5553605 200 µM 0.0917948165525416 0.443002998447621 no 1435 0.463430531233547 494 6758546
SGTC_3170 9103054 49.47 µM 0.0909212734996732 0.443397271933109 no 1436 0.463777573197147 504 16432970
SGTC_3319 9138450 16.7555 µM 0.0904512398789678 0.443609444731821 no 1437 0.463964319996399 517 2029690
SGTC_273 hydroxyurea 18.1 mM 0.0902054995192118 0.443720378172102 no 1438 0.464061957081107 507 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_994 3910-0338 138 µM 0.0887810901098998 0.444363479361673 no 1439 0.464627943122027 507 3479481
SGTC_414 piperonyl butoxide 100 µM 0.0885586424273346 0.444463924689307 no 1440 0.464716338725291 502 5794 A potent inhibitor of cytochrome P450.
SGTC_1723 st034307 2.5525 µM 0.0879285762789866 0.444748447780691 no 1441 0.464966721987891 503 867466
SGTC_1615 st002656 86.5 µM 0.0879006016185634 0.444761081142222 no 1442 0.464977839217199 500 1584458
SGTC_908 3448-7491 47.7 µM 0.086948029606663 0.445191296231243 no 1443 0.465356410971743 505 1203031
SGTC_66 0109-0187 42.4 µM 0.0867423747802894 0.445284185688882 no 1444 0.465438146566534 434 759417
SGTC_2413 inermin 26.06 µM 0.0853496745568041 0.445913314490571 no 1445 0.465991700493221 508 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_25 0118-0223 35.662 µM 0.0836505944814961 0.44668102950766 no 1446 0.466667119644093 507 5333628
SGTC_1561 5-methoxyflavone 52.9 µM 0.0831564380340403 0.446904347581785 no 1447 0.466863575066134 510 94525
SGTC_161 4065-0411 162.148 µM 0.0828864935211387 0.447026347416673 no 1448 0.466970896846206 508 1906281 YLR208W SEC13
SGTC_742 0kpi-0133 140 µM 0.0828134747885084 0.447059348665306 no 1449 0.466999927300477 519 2728852
SGTC_1522 st012842 45.6 µM 0.0820445695813517 0.447406882137688 no 1450 0.467305635748862 526 3491067 YOR116C RPO31
SGTC_1909 st060837 51.5 µM 0.0817991445536773 0.447517819036558 no 1451 0.467403218171698 507 678937
SGTC_370 0180-0345 38.7 µM 0.0812907227529243 0.447747648659008 no 1452 0.467605375872023 483 3989527
SGTC_2026 5148700 152 µM 0.0800817664366467 0.448294221846015 no 1453 0.468086112221148 511 79838
SGTC_1794 st048918 76.9 µM 0.0794849917432273 0.448564061931825 no 1454 0.468323434347799 511 672303
SGTC_2600 tangeritin 87.95 µM 0.0792061611082095 0.448690147296583 no 1455 0.468434322067803 508 68077 A bioactive flavone.
SGTC_130 0136-0219 337.655 µM 0.0787776614095549 0.448883922117283 no 1456 0.468604736214753 526 234244
SGTC_674 0498-0004 451 µM 0.0786182823597981 0.448955999136412 no 1457 0.468668122664118 492 4231473
SGTC_2867 9039098 71.43 µM 0.0782360514525075 0.449128864753406 no 1458 0.468820142490007 492 6463460
SGTC_2284 7945075 39.21 µM 0.0781296131680566 0.449177003658237 no 1459 0.468862475642127 513 1245402
SGTC_1855 st056195 39.6 µM 0.0767368850382363 0.449806962296657 no 1460 0.469416430510462 517 4028379
SGTC_692 k241-0027 77.8 µM 0.0762517050761922 0.450026448638855 no 1461 0.46960942384386 510 3600480
SGTC_3124 9127567 49.47 µM 0.0758274958315982 0.450218365497256 no 1462 0.469778170292397 500 17592030
SGTC_1247 0448-0043 5.84 µM 0.0756330751867068 0.450306327396748 no 1463 0.469855510812538 500 3089013 YGL099W LSG1
SGTC_1604 st002052 72.4 µM 0.0748165177534013 0.450675789785355 no 1464 0.470180349692343 512 6254834 YHR062C RPP1
SGTC_898 1000-0849 28.3 µM 0.0747353594369874 0.450712513297238 no 1465 0.470212636784177 517 6751807
SGTC_495 decylubiquinone 155 µM 0.0745887667183257 0.450778846440341 no 1466 0.470270956042732 516 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1634 st006576 41 µM 0.0740802404046985 0.451008965026538 no 1467 0.470473268962912 517 3915356
SGTC_2972 9093619 59.92 µM 0.0740253452827622 0.451033807181166 no 1468 0.470495108982539 458 25236256
SGTC_1706 st031321 9.9705 µM 0.0730811111228925 0.45146113940647 no 1469 0.470870786300213 513 6103185
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.0728447870218343 0.451568101468774 no 1470 0.470964815356222 525 229346 A bile salt which induces apoptosis.
SGTC_1224 0823-0416 294 µM 0.0723091888393829 0.451810530229901 no 1471 0.471177926102389 503 3598164
SGTC_1893 st059353 36.1 µM 0.0718487738317294 0.452018943064051 no 1472 0.471361128591965 520 3112488
SGTC_1347 1493-0251 600 nM 0.0718177956316334 0.452032966224153 no 1473 0.471373455261756 513 3986378
SGTC_1729 st035615 45.989 µM 0.0710168653184621 0.452395550751918 no 1474 0.471692166398836 531 17385451
SGTC_577 r071-0003 38.6 µM 0.0709906899373729 0.452407401128857 no 1475 0.471702582575171 514 4568517 YMR134W ERG29
SGTC_96 0929-0093 37.281 µM 0.0709153686329656 0.452441501569876 no 1476 0.471732555885267 513 6991579
SGTC_3108 9121785 49.47 µM 0.0704814395456791 0.452637962416932 no 1477 0.471905236452268 519 17140271
SGTC_2111 5486399 200 µM 0.0704632149631918 0.452646213827728 no 1478 0.471912488977102 508 689674
SGTC_1529 apigenin 74 µM 0.0696950712092291 0.452994019203573 no 1479 0.472218182424663 520 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2713 st079149 53.4 µM 0.0682593310342279 0.453644199944131 no 1480 0.472789598858928 521 3103253
SGTC_1337 1486-1011 40.3 µM 0.0679011112075261 0.453806440678244 no 1481 0.472932177090456 521 X1337
SGTC_3025 9087895 49.47 µM 0.0678961893673998 0.453808669874256 no 1482 0.472934136099633 511 17173641
SGTC_2017 5132927 60.65 µM 0.0678396227051692 0.453834290107494 no 1483 0.472956651020644 504 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_934 2950-0684 338 µM 0.0675951105728503 0.45394503701298 no 1484 0.473053973848235 517 1121253
SGTC_3194 9111903 49.47 µM 0.0672870116307897 0.454084589396781 no 1485 0.473176608335908 522 17087251
SGTC_3203 9113543 49.47 µM 0.0662645394687771 0.454547755265095 no 1486 0.473583607276903 496 17018012
SGTC_1606 st000094 49.2 µM 0.0656659971125626 0.454818915465384 no 1487 0.473821872166611 514 1242210
SGTC_3289 9119912 71.43 µM 0.0651938332472518 0.455032836740074 no 1488 0.474009835520602 521 17014829
SGTC_3320 9137005 35.139 µM 0.064475450094751 0.455358336534124 no 1489 0.474295827207983 523 4908713
SGTC_180 1486-1293 102.781 µM 0.0630054298080974 0.456024496697233 no 1490 0.474881090276194 509 4140536
SGTC_121 0557-0495 61.343 µM 0.06177688863019 0.456581322160717 no 1491 0.475370254263699 524 3104427
SGTC_21 0849-0113 22.993 µM 0.0616166563311527 0.456653952347556 no 1492 0.475434056156085 523 1560156
SGTC_1788 fluconazole 20 µM 0.0609308129334124 0.456964848164451 no 1493 0.475707154927684 523 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_565 1418-0001 44.5 µM 0.0603481586190665 0.45722898862053 no 1494 0.475939173389843 505 2862145
SGTC_1805 st050013 60.3 µM 0.0602297774482092 0.45728265784359 no 1495 0.47598631489216 528 4037144
SGTC_322 k048-0136 19.3 µM 0.0602174720047784 0.457288236677429 no 1496 0.475991215159408 496 6823282
SGTC_1546 5-methoxyflavanone 78.7 µM 0.0600210574903585 0.457377284906935 no 1497 0.476069431735669 516 147795
SGTC_2610 ononetin 44.17 µM 0.0597299491658219 0.457509268298436 no 1498 0.476185359163421 515 259632
SGTC_2526 patulin 37.61 µM 0.0596790716157763 0.457532335765788 no 1499 0.476205620225475 510 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2765 myclobutanil 7.74 µM 0.0594715135131551 0.45762644240274 no 1500 0.476288277114318 518 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_646 4092-0839 27.3 µM 0.0587732355244478 0.457943058357936 no 1501 0.476566363278026 519 877796
SGTC_1134 3477-0009 42.5 µM 0.0575918529034443 0.458478786189062 no 1502 0.477036869672091 524 3973534
SGTC_2066 5222451 176 µM 0.0574091846852726 0.458561628470583 no 1503 0.477109623374899 529 2281147
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.0567357471695412 0.458867056180242 no 1504 0.477377848871208 501 16725076
SGTC_1508 1080-0625 72.9 µM 0.055886750006839 0.459252140975394 no 1505 0.477716013147815 517 767111
SGTC_2862 9027634 71.43 µM 0.0557969766533149 0.459292862261686 no 1506 0.477751771737441 522 5012562
SGTC_1961 st076550 68.7 µM 0.0556306696081031 0.459368300438061 no 1507 0.477818015757688 511 1579337
SGTC_314 1671-0008 2.74 µM 0.0554282840263046 0.459460106094056 no 1508 0.477898631536915 518 3913060
SGTC_2594 a-mangostin 100 µM 0.0547941779504781 0.459747761726805 no 1509 0.478151219379256 518 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2198 6589944 200 µM 0.0542550739278299 0.459992337244025 no 1510 0.478365971305713 519 5290268
SGTC_2844 9010103 25.97 µM 0.0538265438065583 0.460186759463608 no 1511 0.478536680635594 524 2480525
SGTC_2962 9082311 13.18 µM 0.0538019353383801 0.460197924506183 no 1512 0.478546483788893 522 16459453
SGTC_918 glabranin 770.725 nM 0.0515213858516574 0.461232761601177 no 1513 0.479455030517401 512 124049 Also referred to as licorice root.
SGTC_3328 9140624 29.0385 µM 0.0512159067183441 0.461371397910314 no 1514 0.479576738375446 525 4904392
SGTC_276 colchicine 750 µM 0.0506012444776396 0.461650365720531 no 1515 0.479821635573912 526 2833 A microtubule depolymerizer.
SGTC_988 1497-1057 103 µM 0.0500895682975671 0.461882607143333 no 1516 0.480025506298526 529 3533044
SGTC_2282 7944268 200 µM 0.0474702654606259 0.463071667596831 no 1517 0.481069214167235 513 2970414
SGTC_2063 5246145 200 µM 0.0470388319502108 0.463267553378896 no 1518 0.481241139173578 527 711240
SGTC_1020 4335-0961 93.3 µM 0.047037103121239 0.463268338345178 no 1519 0.481241828113964 516 669075
SGTC_2809 7964133 12.99 µM 0.0467482044656204 0.463399513363707 no 1520 0.48135695535458 519 1253665
SGTC_505 gw-5074 63.9 µM 0.045483845191967 0.463973644878355 no 1521 0.481860825620608 524 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.0450917776881066 0.464151693677201 no 1522 0.482017077606174 519 94937 An inhibitor of serotonin biosynthesis.
SGTC_1770 st043884 66.3 µM 0.0445650529606371 0.464390905375652 no 1523 0.482226999333697 531 670149
SGTC_1256 0570-0116 285 µM 0.0444346530303135 0.46445012841181 no 1524 0.482278969896731 510 410638
SGTC_2996 9066192 71.4286 µM 0.0436199020763634 0.46482017726007 no 1525 0.482603693616304 522 6472854
SGTC_2971 9092186 9.93 µM 0.0435165842492879 0.464867104998385 no 1526 0.482644872364691 532 25236400
SGTC_1295 1013-0063 9.78 µM 0.0431205368954065 0.465046997222449 no 1527 0.482802724224339 522 6826038
SGTC_3090 9117696 49.47 µM 0.0430182338045452 0.465093466390233 no 1528 0.482843499416719 532 7923821
SGTC_1902 st060212 70.5 µM 0.0426727019534633 0.46525042095605 no 1529 0.482981220213243 516 688944
SGTC_2134 5324836 1.464 µM 0.0425464322751442 0.465307779109777 no 1530 0.483031548818196 536 699272
SGTC_2961 9083290 32.55 µM 0.0423119401859848 0.465414299335459 no 1531 0.483125013459694 535 17741490
SGTC_1459 k035-0031 35.7 µM 0.0422002944442335 0.46546501632964 no 1532 0.483169513919189 529 3877128 YMR208W ERG12
SGTC_1054 3429-0080 167 µM 0.0421872005227633 0.465470964504945 no 1533 0.483174732990223 524 1162877
SGTC_318 1488-0629 67.2 µM 0.042115516200908 0.465503528676328 no 1534 0.483203305502849 518 3662576
SGTC_1046 2001-0062 216 µM 0.0412079240948815 0.465915842148989 no 1535 0.483565068263006 524 739778
SGTC_3130 9127414 49.47 µM 0.0403220835721211 0.466318309299136 no 1536 0.483918173974787 533 1494646
SGTC_2484 5809818 12.04 µM 0.0395580468305752 0.466665464576136 no 1537 0.484222737509248 533 2870548
SGTC_1387 3342-1166 1.8 µM 0.038842891834511 0.466990432445513 no 1538 0.484507823941124 525 3418228
SGTC_2302 7771753 200 µM 0.0385951904119884 0.467102993612028 no 1539 0.484606568466358 530 2203047
SGTC_3066 9117245 49.47 µM 0.0384873290213031 0.467152009106695 no 1540 0.484649566988023 531 17176980
SGTC_1433 4060-0023 7.6 µM 0.0384494561306291 0.467169219817661 no 1541 0.484664664910177 530 3840627
SGTC_2245 6637752 200 µM 0.0381509205521659 0.46730488653724 no 1542 0.484783676053183 517 681890
SGTC_511 blebbistatin 171 µM 0.0372338021862432 0.467721686145353 no 1543 0.485149293521462 510 3476986 A myosin inhibitor.
SGTC_2412 st077135 33.4 µM 0.0368071813637198 0.467915583121266 no 1544 0.485319374014947 518 13258915
SGTC_1678 st019265 80.2 µM 0.0360350882091667 0.468266514823346 no 1545 0.485627190384285 530 5367020
SGTC_1977 st070720 65.3 µM 0.0356567587693232 0.468438482101302 no 1546 0.48577802505571 505 682188
SGTC_496 calpeptin 138 µM 0.0351773873038703 0.468656385853819 no 1547 0.485969146693336 538 73364 A calpain inhibitor.
SGTC_917 harmaline 728.087 nM 0.0343486444821182 0.469033122442462 no 1548 0.486299567523352 524 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_708 3448-5400 146 µM 0.0340980285140794 0.469147054944243 no 1549 0.486399490295135 539 3462195
SGTC_2703 st077852 53.4 µM 0.0340647222773154 0.469162196479816 no 1550 0.486412769846575 518 6281836
SGTC_2617 dihydrotanshinone i 20.83 µM 0.0336602803926314 0.469346065631768 no 1551 0.486574026332827 535 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1927 st060202 13.8 µM 0.0324117721066315 0.46991370903959 no 1552 0.487071837318862 535 688887
SGTC_1545 lovastatin 49.4 µM 0.0319977129903744 0.470101977599301 no 1553 0.487236937367159 530 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_295 k015-0027 31 µM 0.0317073178957515 0.470234021349073 no 1554 0.487352729492771 528 3887424
SGTC_3176 9106582 49.47 µM 0.0315926242641483 0.470286173880376 no 1555 0.487398462719988 534 17018027
SGTC_1806 st050005 60.3 µM 0.0310556061356858 0.470530369049127 no 1556 0.487612596874192 528 5194765
SGTC_969 1313-0238 134 µM 0.0308332495170341 0.470631483246633 no 1557 0.487701261869432 534 5212874
SGTC_1128 3448-9350 235 µM 0.0307860019247331 0.470652968807504 no 1558 0.487720101987692 529 619386
SGTC_578 3460-0051 92 µM 0.0294714716238642 0.471250777652923 no 1559 0.488244285700389 537 2876744
SGTC_2589 lobaric acid 100 µM 0.0292229118624227 0.471363822480904 no 1560 0.488343404005788 527 73157 A novel microtubule depolymerizer.
SGTC_2858 9025781 8.96 µM 0.0287500043998994 0.471578906869929 no 1561 0.48853198754357 528 4894980 YPL153C RAD53
SGTC_3082 9117008 49.47 µM 0.028320656722309 0.471774186890168 no 1562 0.488703202762359 537 41448529
SGTC_878 0828-0289 13.7 µM 0.0282000294152756 0.471829052979653 no 1563 0.488751306882335 532 745350 YLR208W SEC13
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0281996069648443 0.471829245127825 no 1564 0.488751475348675 527 23847180
SGTC_3119 9125183 49.47 µM 0.028043230511387 0.471900372146763 no 1565 0.488813835864889 535 22695334
SGTC_947 3447-0010 211 µM 0.0279655974909559 0.471935683456557 no 1566 0.48884479481697 534 748350
SGTC_1988 st071872 53.4 µM 0.0278442079666923 0.471990897814956 no 1567 0.488893203379421 538 16414116
SGTC_440 fluspirilene 35.1 µM 0.0276534510761583 0.472077665197536 no 1568 0.48896927507507 530 3396 An atypical antipsychotic.
SGTC_1552 6-methylflavone 10.6 µM 0.0273800898499676 0.472202008168926 no 1569 0.48907828914663 535 689013
SGTC_445 e6 berbamine 66 µM 0.0266863091528755 0.472517598174225 no 1570 0.489354966478957 540 6610268 A calcium/calmodulin antagonist.
SGTC_2077 5212015 200 µM 0.0266815538687148 0.472519761338494 no 1571 0.489356862887592 528 780900
SGTC_1094 duloxetine 25.4 µM 0.0259376091563876 0.472858189461761 no 1572 0.48965355118007 533 60834 A selective serotonin reuptake inhibitor.
SGTC_1504 k297-0033 30 µM 0.0258008171016871 0.472920419718262 no 1573 0.489708105057047 539 4388117
SGTC_2640 pentamidine 10.38 µM 0.0257655791170503 0.472936450499294 no 1574 0.489722158307105 537 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1119 parthenolide 318.541 nM 0.0252705167260963 0.473161673358534 no 1575 0.489919595331202 532 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1391 3442-0225 151 µM 0.0252389152020761 0.473176050395304 no 1576 0.489932198495464 530 5227075
SGTC_628 1636-0253 16 µM 0.0244744830812678 0.47352383753793 no 1577 0.490237068584152 530 4456143
SGTC_1378 2093-0007 380 nM 0.0229305645736446 0.474226322203339 no 1578 0.490852829898581 542 3618014
SGTC_229 benomyl 22.8748 µM 0.0227935953648604 0.474288647250602 no 1579 0.490907458428694 519 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_363 0455-0021 3.06 µM 0.0219357380477493 0.474679011993226 no 1580 0.491249608393855 539 4597466
SGTC_2129 girgensonine 121.053 µM 0.0217436090788846 0.474766442902525 no 1581 0.491326238485349 543 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1193 1488-0126 41.5 µM 0.021664928673248 0.47480224784584 no 1582 0.491357620033382 533 1384710
SGTC_1708 st033234 31.827 µM 0.0211235127460843 0.475048634470429 no 1583 0.491573564309502 531 674664
SGTC_729 4092-0585 94.1 µM 0.0197646883393956 0.475667047753134 no 1584 0.492115543500299 538 2169061
SGTC_2930 9013230 14.89 µM 0.0196417552311629 0.475722998636888 no 1585 0.492164577196023 534 2995857
SGTC_3139 9095020 49.47 µM 0.0195421879591013 0.475768315314264 no 1586 0.492204291167833 540 25236292
SGTC_553 k007-0256 45.7 µM 0.0194561339074089 0.475807481887387 no 1587 0.492238615241519 523 6287000
SGTC_1867 st057372 64 µM 0.0188787277591842 0.4760702880933 no 1588 0.492468924653191 532 688837
SGTC_1994 st072947 40.9 µM 0.0184247603924037 0.476276918496475 no 1589 0.492649999928511 538 5286565 YDL195W SEC31
SGTC_713 1488-1073 324 µM 0.0181805980121884 0.476388055494488 no 1590 0.492747390311346 543 3312542
SGTC_113 0099-0221 2.5 µM 0.017719902976796 0.476597758082132 no 1591 0.492931151430353 541 89219
SGTC_963 1269-2853 151 µM 0.0176302125585089 0.476638584788361 no 1592 0.492966927141603 540 3668223
SGTC_786 4544-0069 423 µM 0.0165943031286464 0.477110144125774 no 1593 0.493380134689287 541 748821 YLR208W SEC13
SGTC_1369 1866-0067 208 µM 0.0164532121452306 0.477174373056582 no 1594 0.493436414164263 537 3531355
SGTC_3272 9137413 49.47 µM 0.016329449081553 0.477230714276607 no 1595 0.493485781850689 524 17614870
SGTC_2032 5185112 25.99 µM 0.0162801637795262 0.477253150774642 no 1596 0.493505441228104 539 5718189
SGTC_2147 5545932 89.7195 µM 0.0156739962416439 0.477529106602577 no 1597 0.49374723622115 541 797404
SGTC_119 0121-0043 24.815 µM 0.0154414311702503 0.477634983972822 no 1598 0.493840005033189 536 1092378
SGTC_606 k015-0008 38.6 µM 0.0152352460933937 0.477728852930313 no 1599 0.493922251302401 538 1970475
SGTC_2238 6671620 73.2395 µM 0.0145213666397155 0.478053867147377 no 1600 0.494207016473414 539 729941
SGTC_2292 7671323 168.05 µM 0.0131051676132476 0.478698675602378 no 1601 0.494771944196861 542 937504
SGTC_2362 9071156 126 µM 0.0120852911263342 0.479163069389674 no 1602 0.495178783758894 545 653133
SGTC_3284 9108171 64.8615 µM 0.0111796383560569 0.479575475921232 no 1603 0.49554006248407 538 8687505
SGTC_2101 5377231 179.231 µM 0.00700161359233581 0.481478296665537 no 1604 0.497206783128791 544 2844213
SGTC_3299 9121982 43.1275 µM 0.00675542138743285 0.481590434924068 no 1605 0.497304997284705 542 17594604 YPL160W CDC60
SGTC_1260 0700-1617 7.75 µM 0.00615110442280963 0.481865701836272 no 1606 0.497546079849042 546 2853078
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.00541825436211541 0.482199527274597 no 1607 0.497838439825315 543 140250 A respiratory chain inhibitor.
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.00528304970637753 0.482261116623318 no 1608 0.497892377906839 544 6708784 An antioxidant flavonoid
SGTC_888 0916-0002 6.97 µM 0.00518169004107072 0.482307288948441 no 1609 0.497932814009313 543 2802138 YIL048W NEO1
SGTC_1829 berberine 14.4 µM 0.0045658349941698 0.482587834214152 no 1610 0.498178501704241 544 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3298 9116858 71.43 µM 0.00370581084933941 0.482979622134919 no 1611 0.498521598752851 543 2506942
SGTC_2201 6605497 169.863 µM 0.00276306062702768 0.483409115167122 no 1612 0.498897699695152 546 670741
SGTC_1754 st042065 16.137 µM 0.00241390410902188 0.483568186911576 no 1613 0.499036992525307 546 1126236 YIL048W NEO1
SGTC_1111 tnp00062 510.699 nM 0.0018192040331172 0.483839131520086 no 1614 0.499274242994829 548 676306
SGTC_671 0560-0003 407 µM 0.00138828678985542 0.484035461545477 no 1615 0.499446153880112 547 3238678
SGTC_1037 k284-1091 78.7 µM 0.000983891770242688 0.484219711313126 no 1616 0.49960748403684 540 3334711
SGTC_97 0535-0701 19.132 µM 0.000798555359216157 0.484304155100327 no 1617 0.499681422537826 546 2832013 YGL099W LSG1
SGTC_1844 rapamycin 4 nM 0.000758993960132543 0.484322180329521 no 1618 0.499697205247806 548 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_851 0394-0702 453 µM 0.000300648762414334 0.484531016959788 no 1619 0.499880058498929 548 762646
SGTC_2286 7945697 125 µM 0.000107990709263103 0.484618799358048 no 1620 0.499956917940268 547 1245733
SGTC_1925 st057770 10.1 µM -0.000188583503598317 0.484753931399813 no 1621 0.499924766067474 548 5989122
SGTC_387 norethindrone acetate 66.7 µM -0.000568226611008664 0.484926915776881 no 1622 0.499773310392218 550 541197
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.0010333007264775 0.485138830654424 no 1623 0.499587772725195 549 4213774
SGTC_2941 9056145 11.23 µM -0.00113310205581872 0.485184306506817 no 1624 0.499547957778655 548 2119517
SGTC_587 k089-0003 57 µM -0.00154608946912922 0.485372491960453 no 1625 0.499383199787213 550 9659696
SGTC_796 1234-0020 70.7 µM -0.00173287353419791 0.485457604692159 no 1626 0.499308683826606 549 46495034
SGTC_1567 st069303 68.4 µM -0.00187056054009873 0.485520345571364 no 1627 0.499253754747689 551 5581319
SGTC_802 4112-3352 742 µM -0.00188172674772314 0.485525433777368 no 1628 0.499249300083196 551 704594
SGTC_2797 7859098 81.82 µM -0.00381097391523807 0.486404585808961 no 1629 0.498479645055857 548 972681
SGTC_2000 st075254 36.4 µM -0.00416749172981276 0.486567057247264 no 1630 0.498337416158378 552 17234175
SGTC_2934 9036370 36.88 µM -0.0047708059473832 0.48684200321183 no 1631 0.498096731015922 554 6462800
SGTC_2982 9019404 25.97 µM -0.00479915695017845 0.486854923655315 no 1632 0.498085420731696 552 22333232
SGTC_3200 9114385 49.47 µM -0.00484362688679269 0.4868751900316 no 1633 0.498067679999976 551 17018030 YLR208W SEC13
SGTC_1742 st038235 28.8875 µM -0.00523899213895711 0.487055372140761 no 1634 0.497909954090012 549 564103 YBR002C RER2
SGTC_2932 9016711 44.54 µM -0.00525338415249305 0.487061931146983 no 1635 0.497904212586323 552 7117328
SGTC_237 nikkomycin 200 µM -0.00526422411799297 0.487066871347619 no 1636 0.497899888125564 552 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2981 9013952 38.96 µM -0.00771626113207401 0.488184411048409 no 1637 0.496921687735298 552 2996344
SGTC_2023 5144124 124 µM -0.00887075381193557 0.488710614968956 no 1638 0.496461127657919 553 2830192
SGTC_1689 st020265 53.493 µM -0.00994377517146873 0.489199702878581 no 1639 0.496033073031476 552 5758320 YPR016C TIF6
SGTC_204 PMA1.184 62.41 µM -0.0102650054642493 0.489346124267435 no 1640 0.495904927228419 553 2252213 YGL008C PMA1
SGTC_1030 k029-0042 36.7 µM -0.0105077023700473 0.48945674996195 no 1641 0.495808110393875 554 6080581
SGTC_590 k048-0076 22.4 µM -0.0106214794264948 0.489508611907809 no 1642 0.495762722448501 555 6832814
SGTC_1692 fluoroquinolonic acid 71 µM -0.0113893006755402 0.489858605377144 no 1643 0.495456424645734 558 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_458 nppb 133 µM -0.0129681585291525 0.490578315271179 no 1644 0.494826598268711 553 4549 A chloride channel blocker.
SGTC_2751 anetholtrithion 17.25 µM -0.0134284161738535 0.490788125965544 no 1645 0.494642998027781 560 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1985 st071382 65.5 µM -0.0136942547922544 0.49090931096256 no 1646 0.494536953515212 573 6123237
SGTC_174 3553-0389 74.3 µM -0.0140326346198769 0.491063565754211 no 1647 0.494401972467753 551 738071
SGTC_2757 clomiphene 4.22 µM -0.0154473375179204 0.491708490454771 no 1648 0.493837649022386 555 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3055 9094636 49.47 µM -0.0156325268513007 0.491792914892191 no 1649 0.493763778087593 556 25236176
SGTC_2064 5220758 200 µM -0.0156747274218123 0.491812153413706 no 1650 0.493746944558297 554 788518
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.0165608318092412 0.492216117645388 no 1651 0.493393485979079 555 688761
SGTC_2665 lovastatin 100 µM -0.0172287858254652 0.492520635071054 no 1652 0.493127048913484 560 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2217 6934799 96.0675 µM -0.017709499083969 0.492739792930656 no 1653 0.49293530133189 558 675606
SGTC_2504 purpurogallin 52.29 µM -0.0198605087900592 0.493720467225247 no 1654 0.492077324173242 561 5281571 An antioxidant.
SGTC_515 4092-1064 102 µM -0.0211301512367211 0.494299332508335 no 1655 0.491570916525884 567 717353
SGTC_2737 bleomycin 30.5 nM -0.0213527351598616 0.494400815977173 no 1656 0.491482138418741 556 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2116 5511452 16.8835 µM -0.0222585081009335 0.494813791879763 no 1657 0.49112087320678 564 870744
SGTC_2726 cimetidine 79.27 µM -0.0223733501963683 0.494866153110514 no 1658 0.491075069245989 555 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3308 9128332 17.569 µM -0.0233168268152539 0.495296326139323 no 1659 0.490698774752595 555 17332805 YDL196W YDL196W
SGTC_2736 butenafine 14.65 µM -0.0242344375279944 0.495714711000057 no 1660 0.490332804507745 558 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1917 st066507 28.5 µM -0.024376242357275 0.495779367383632 no 1661 0.490276249273284 560 3156428
SGTC_449 xestospongin c 11.1929 µM -0.0260979845124877 0.496564409788128 no 1662 0.489589592321219 564 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1640 st009078 66.4 µM -0.0270870823404257 0.497015403236882 no 1663 0.489195138890338 564 690618
SGTC_890 0929-0006 47.2 µM -0.0274730324408841 0.497191383829168 no 1664 0.489041224360466 567 1378169
SGTC_648 0375-0473 33.3 µM -0.0275328600267589 0.497218663296646 no 1665 0.489017365632151 563 1713139
SGTC_785 1270-0111 65.3 µM -0.0278225308271945 0.49735074410736 no 1666 0.488901847957774 565 6741994
SGTC_2924 9010168 62.78 µM -0.0280786560855862 0.497467529444124 no 1667 0.488799708668623 572 2993929
SGTC_419 nsc-638432 893 µM -0.0295480424740136 0.498137528886072 no 1668 0.48821375164864 569 368090
SGTC_1899 st063254 59.6 µM -0.03023029289199 0.49844861805604 no 1669 0.487941694666239 559 3093813
SGTC_1178 0988-0033 191 µM -0.0302363767897097 0.498451392166146 no 1670 0.487939268651217 562 5392207
SGTC_2124 5246320 200 µM -0.0302675230462725 0.498465594106443 no 1671 0.487926848777112 575 579342
SGTC_1453 4237-0541 195 µM -0.0303249838994553 0.498491794871957 no 1672 0.487903935731244 565 739892
SGTC_1067 clotrimazole 1.36 µM -0.0303329730272044 0.498495437722367 no 1673 0.487900749995933 558 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_720 r052-1644 49.9 µM -0.0309873810957122 0.498793832485422 no 1674 0.487639801634044 558 1422863 YOR257W CDC31
SGTC_1202 1988-0068 29.6 µM -0.0317068039668971 0.499121873249159 no 1675 0.487352934417685 561 2850480
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.0318126602891178 0.499170141423631 no 1676 0.487310725148327 566 5377381
SGTC_2268 7933382 153.85 µM -0.0325503233887034 0.499506500008717 no 1677 0.487016592504321 564 935025 YOR257W CDC31
SGTC_2568 diosmetin 100 µM -0.0331206958427908 0.499766577892891 no 1678 0.486789169453376 561 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3085 9117376 49.47 µM -0.0341445236894205 0.499766577892891 no 1679 0.486380952198596 564 16480349
SGTC_479 n-linoleoylglycine 10 µM -0.0355803931307774 0.499111851960171 no 1680 0.485808471218297 560 6433346 An anti-infammatory.
SGTC_701 4424-0219 185 µM -0.0358353630967285 0.498995591276974 no 1681 0.485706817746344 573 2911779
SGTC_1379 2144-0755 36.5 µM -0.0359331762450129 0.498950990659926 no 1682 0.485667821061656 567 5392327
SGTC_1209 2323-2347 50.3 µM -0.0365724700633235 0.498659487265836 no 1683 0.48541294727344 556 5412760
SGTC_3215 9129942 49.47 µM -0.036586770128496 0.498652966770012 no 1684 0.485407246188328 561 17682944
SGTC_537 1334-0398 209 µM -0.0383296681150519 0.497858249203681 no 1685 0.484712418212862 588 5846986
SGTC_3167 9103034 49.47 µM -0.0396032177690012 0.497277547846148 no 1686 0.484204731022311 565 5127859
SGTC_2373 9071805 200 µM -0.0396572270029243 0.497252921335484 no 1687 0.484183201368757 601 10149009
SGTC_1228 0124-0032 52.5 µM -0.0424851372199529 0.495963500156076 no 1688 0.483055979916578 581 X1228
SGTC_906 1165-0455 526 µM -0.0431700273614975 0.495651221725781 no 1689 0.482782998753121 591 3252859
SGTC_998 3996-0085 177 µM -0.0431951110175497 0.495639784780764 no 1690 0.482773001147961 564 715391
SGTC_2960 9079389 5.97 µM -0.0445548267157316 0.495019825199154 no 1691 0.482231074966886 574 16457355
SGTC_1503 4585-0012 61.3 µM -0.0446352432152954 0.494983159823249 no 1692 0.482199025309877 586 2922052
SGTC_2253 7938677 135.83 µM -0.046434716812506 0.494162713292745 no 1693 0.481481883165258 582 2301972
SGTC_1064 honokiol 6.76 µM -0.0467581121097268 0.494015267939299 no 1694 0.481353007093974 578 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2947 9072639 7.68 µM -0.0475101438954396 0.493672397897851 no 1695 0.481053322903559 581 16488146
SGTC_2270 7924575 90.91 µM -0.0477964832012404 0.493541849884108 no 1696 0.480939219676889 600 1262135
SGTC_2870 9038528 12.99 µM -0.0480958503839611 0.49340536293156 no 1697 0.480819926647106 598 6463316
SGTC_1435 4092-0789 56.7 µM -0.0488753057465236 0.493049998693385 no 1698 0.480509334248062 564 2248285
SGTC_637 1181-0519 7.26 µM -0.0490468874285309 0.49297177301561 no 1699 0.480440965056717 566 6252091 YGR060W ERG25
SGTC_1293 1000-1278 195 µM -0.0496026074307836 0.492718416990982 no 1700 0.480219534381246 581 678847
SGTC_233 rapamycin 362 pM -0.0496345495321841 0.492703854486971 no 1701 0.480206807003544 568 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_192 3455-0609 60.9 µM -0.0499320178807839 0.492568238205258 no 1702 0.480088281269312 580 3769639
SGTC_2853 9015042 58.44 µM -0.0499616722316876 0.492554718787492 no 1703 0.480076465642282 562 6457456
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.0501837645939718 0.492453467158549 no 1704 0.479987974614325 602 5024745
SGTC_2348 9022543 33.42 µM -0.0506767463312637 0.492228719150814 no 1705 0.479791553287119 580 3162678 YDL140C RPO21
SGTC_3278 9139605 49.47 µM -0.0509333582034219 0.492111732001808 no 1706 0.479689311997348 608 7958859
SGTC_2543 pimpinellin 60.67 µM -0.0512223537085944 0.49197998224543 no 1707 0.479574169769903 578 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3300 9124615 50.48 µM -0.0514096899939524 0.491894578234992 no 1708 0.479499531743285 582 24824903
SGTC_481 bay k-8644 50 µM -0.0518594977249103 0.491689518662756 no 1709 0.479320323478547 600 2303 A calcium channel antagonist.
SGTC_500 h-89 112 µM -0.0520314587442691 0.49161112518274 no 1710 0.479251813451232 574 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1786 berberine 21.6 µM -0.0529755732494428 0.491180728716926 no 1711 0.478875685050349 592 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1015 4130-4525 82 µM -0.0530618809301047 0.491141383866206 no 1712 0.478841301627048 584 1363237
SGTC_2054 5233173 129 µM -0.0531781167297933 0.49108839590047 no 1713 0.478794995629801 573 6889
SGTC_657 3534-0529 86.7 µM -0.0540218406906419 0.490703775484617 no 1714 0.478458881646364 580 1049549
SGTC_1371 2421-0008 32.7 µM -0.0544890801549668 0.490490783170654 no 1715 0.478272754219827 577 2827552
SGTC_2502 avocadyne acetate 18.59 µM -0.054496723628626 0.490487298895863 no 1716 0.478269709439075 575 3952079
SGTC_2838 9002687 71.43 µM -0.0547228655907577 0.490384212491229 no 1717 0.47817962627374 590 6457060
SGTC_2057 5236571 38.335 µM -0.054881957485928 0.490311691122873 no 1718 0.478116253026416 581 54684039 YBR257W POP4
SGTC_1299 1079-1439 3.74 µM -0.0551801125175423 0.49017577927567 no 1719 0.477997486352231 588 323161
SGTC_1253 0550-0034 176 µM -0.0570462923721245 0.489325121024818 no 1720 0.477254159588102 577 5969915
SGTC_1264 0783-0040 158 µM -0.0573084242257724 0.489205637615246 no 1721 0.477149754911012 573 2855798
SGTC_2261 9010538 184.68 µM -0.0579025552316341 0.488934827895221 no 1722 0.47691312387936 634 6457250
SGTC_2375 9072683 200 µM -0.0597911472972563 0.488074026832345 no 1723 0.476160988198487 576 16798029
SGTC_609 0986-0026 86.3 µM -0.0600165360487418 0.487971300562834 no 1724 0.476071232283958 585 2848610
SGTC_761 k216-0224 480 µM -0.0601221513676472 0.487923164150318 no 1725 0.476029173816631 577 1340404
SGTC_1972 st070201 17.4 µM -0.0609525474036973 0.48754469980171 no 1726 0.475698500214795 574 2829099
SGTC_1018 4259-0013 28.1 µM -0.0610965624301325 0.48747906411585 no 1727 0.475641153410903 594 6801262
SGTC_1176 0848-0131 83.3 µM -0.0615331163926513 0.487280104188048 no 1728 0.475467320649227 574 6769040
SGTC_1820 st053765 18.6 µM -0.0622248350291565 0.486964859193469 no 1729 0.475191892657494 579 3690829
SGTC_3037 9091026 49.47 µM -0.063938207758477 0.486184039365402 no 1730 0.474509714556382 594 25236398 YIL048W NEO1
SGTC_2973 9094665 17.96 µM -0.0645456999262486 0.485907205028655 no 1731 0.47426785983531 571 25237061 YIL048W NEO1
SGTC_2132 5317594 122.667 µM -0.0665745097073825 0.484982725858506 no 1732 0.473460219509792 575 794577
SGTC_2697 mebhydrolin 72.4 µM -0.0666265630532858 0.484959007458217 no 1733 0.473439499234026 585 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_220 paclitaxel 373.376 µM -0.0670277244567277 0.48477621779659 no 1734 0.473279815950547 603 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3023 9089636 49.47 µM -0.0671395511930706 0.484725264382201 no 1735 0.473235303807226 567 17249241
SGTC_29 0299-0004 12.984 µM -0.0673226686813875 0.48464182815491 no 1736 0.473162415413818 581 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2898 9056270 58.44 µM -0.0678115424198229 0.484419079493825 no 1737 0.472967827696041 580 19154699
SGTC_2009 4012297 12.05 µM -0.067847078501319 0.484402888150972 no 1738 0.472953683425695 602 45595307
SGTC_2831 7999036 19.48 µM -0.0685456064300099 0.484084622378069 no 1739 0.47267565837009 587 2988270
SGTC_2850 9015429 58.44 µM -0.0688274745527885 0.483956199483905 no 1740 0.472563474204676 581 6457570
SGTC_3196 9111891 49.47 µM -0.0694826690013711 0.483657690565915 no 1741 0.47230271372159 577 18891510
SGTC_1857 st056007 79.3 µM -0.070007177893698 0.483418729044933 no 1742 0.472093973262064 578 619834
SGTC_1066 ketoconazole 628 nM -0.0701070645355929 0.483373222264217 no 1743 0.472054221926954 575 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_814 3342-0569 96 µM -0.0701707150256955 0.483344224216441 no 1744 0.472028891438191 576 4346283
SGTC_1755 st041960 45.185 µM -0.0715223069696986 0.482728483656544 no 1745 0.471491035811926 577 2257073
SGTC_3116 9124943 49.47 µM -0.071545453224332 0.48271793934351 no 1746 0.471481825387804 571 41905195 YPL160W CDC60
SGTC_442 cape 100 µM -0.0715913384638024 0.482697036285586 no 1747 0.471463566646622 579 5281787
SGTC_727 3032-0951 202 µM -0.0719323258890777 0.482541700682302 no 1748 0.47132788216772 592 3652836
SGTC_966 1300-0360 30.2 µM -0.0719356280460756 0.482540196409399 no 1749 0.471326568201635 579 70588
SGTC_1177 0983-0204 23.6 µM -0.0721910269921876 0.482423852085846 no 1750 0.471224942982958 578 766818
SGTC_2162 5663267 200 µM -0.07353090899227 0.481813507582161 no 1751 0.470691824410678 620 6456493
SGTC_2623 humulene 100 µM -0.0739786355907369 0.481609568106242 no 1752 0.470513692499456 599 6187145 An anti-inflammatory.
SGTC_2012 4023501 200 µM -0.07529551630734 0.481009757003852 no 1753 0.469989794412966 582 3477460
SGTC_1953 st076800 12.1 µM -0.0755751723124695 0.480882385141514 no 1754 0.469878544792139 581 297591
SGTC_1763 st044482 94.5 µM -0.0773559452434929 0.480071362297366 no 1755 0.469170193161007 583 88505
SGTC_2371 9071574 200 µM -0.0774504931982467 0.480028304310686 no 1756 0.469132586807937 579 45596039
SGTC_1824 st053723 68.6 µM -0.0778773453267783 0.479833914930801 no 1757 0.468962810239867 604 675225
SGTC_2827 7993847 71.43 µM -0.07800486163007 0.479775844659556 no 1758 0.468912092878579 585 2985692
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.0780211649063694 0.479768420261975 no 1759 0.468905608574243 645 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2374 9071832 200 µM -0.0784263483193287 0.479583904841493 no 1760 0.468744457573534 577 17381698
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.0789725066560229 0.479335198147338 no 1761 0.468527245628489 583 165521
SGTC_1329 1447-1697 50.6 µM -0.0801132034729227 0.478815779727908 no 1762 0.46807361082462 588 2840515
SGTC_1965 Pectolinarigenin 58.4 µM -0.080451885138972 0.478661567287472 no 1763 0.467938931113872 588 5320438 An anti-inflammatory.
SGTC_1213 1315-0166 115 µM -0.0807381562877689 0.478531221498225 no 1764 0.467825095762395 603 768401
SGTC_1236 0330-0013 258 µM -0.0810939180701916 0.478369238238634 no 1765 0.467683631218091 610 4617066
SGTC_1568 digitonin 820 nM -0.081328173048473 0.47826258065662 no 1766 0.467590484671712 595 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_61 0978-8327 98.565 µM -0.0816256351805331 0.47812714675382 no 1767 0.467472207693149 616 6150059 YHR072W ERG7
SGTC_3118 9124250 49.47 µM -0.0820135350694839 0.477950540521361 no 1768 0.467317975143438 581 1504786
SGTC_835 0312-0010 67.2 µM -0.0830900328519816 0.477460446599297 no 1769 0.466889975536503 586 1626196
SGTC_1399 3562-5772 25 µM -0.083146507326894 0.477434736568767 no 1770 0.466867523172535 573 23847490
SGTC_1125 tnp00248 1.32998 µM -0.0859250626307838 0.476169916097093 no 1771 0.465762994044467 606 24207736
SGTC_1683 st010134 710 nM -0.0869920402579048 0.475684282493253 no 1772 0.46533891953816 628 3818134
SGTC_289 k017-0060 526 µM -0.0879856995150786 0.475232052124724 no 1773 0.464944021096131 594 5512909
SGTC_3187 9109394 49.47 µM -0.0881592763124645 0.475153057779362 no 1774 0.46487504201948 581 17098090
SGTC_297 0986-0032 24 µM -0.0882604024613847 0.475107035984222 no 1775 0.464834855174 586 2847425
SGTC_2834 9001755 58.44 µM -0.0882878813700935 0.475094530584579 no 1776 0.464823935304071 627 2989575
SGTC_2988 9073640 71.4286 µM -0.088693840128521 0.474909785337595 no 1777 0.464662614054163 592 9102229
SGTC_2817 7995342 71.43 µM -0.0904303702543615 0.474119580023096 no 1778 0.46397261179106 598 18879975
SGTC_833 3852-0053 558 µM -0.0906583815741336 0.474015831324099 no 1779 0.463882020543917 599 3123681
SGTC_2803 7707263 71.43 µM -0.0917187292437347 0.47353337989821 no 1780 0.463460758164937 597 2199229
SGTC_2871 9038510 12.99 µM -0.0921753674979864 0.473325624321976 no 1781 0.463279354300731 598 4945164
SGTC_899 1083-0020 478 µM -0.0922301347252355 0.47330070749832 no 1782 0.463257598013907 598 767123
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.0923750979813113 0.473234755715795 no 1783 0.463200011875656 600 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_232 clozapine 119 µM -0.0927715546276379 0.473054389468016 no 1784 0.463042524823853 589 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1514 1189-1591 158 µM -0.0930544560540841 0.472925688054993 no 1785 0.462930149590344 619 767698 YMR146C TIF34
SGTC_3142 9086498 49.47 µM -0.09316689384552 0.472874537090573 no 1786 0.462885487423181 614 25236367
SGTC_1219 1469-0211 33.1 µM -0.0951265517237184 0.471983108781647 no 1787 0.462107154238422 604 6822282
SGTC_1570 verbenone 133 µM -0.095990688661871 0.471590066052751 no 1788 0.461763983892064 588 29025 A natural terpanoid with antifungal properties.
SGTC_3103 9120822 49.47 µM -0.0965712733099679 0.471326009331235 no 1789 0.461533435208414 578 17141819
SGTC_2237 6667747 47.222 µM -0.0966213291185565 0.471303243949759 no 1790 0.461513558778591 620 729940 YDL015C TSC13
SGTC_1853 st056710 91.2 µM -0.0983438215089012 0.470519912054672 no 1791 0.46082964113711 617 269167
SGTC_2714 st079313 56.9 µM -0.0995119864853319 0.469988734437135 no 1792 0.460365885650064 585 2939799
SGTC_1321 1326-2144 215 µM -0.0995419857309962 0.469975094145468 no 1793 0.460353976811117 622 3513030
SGTC_3316 9136639 10.545 µM -0.0995480815123871 0.469972322472211 no 1794 0.460351556965323 590 4903665
SGTC_2969 9091408 28.7 µM -0.099569714355313 0.469962486309008 no 1795 0.460342969375258 604 4286311
SGTC_1448 4255-0083 152 µM -0.0999590839458537 0.469785448324175 no 1796 0.46018840448812 638 5399660
SGTC_153 4077-0274 519.67 µM -0.100483091166009 0.46954720293683 no 1797 0.459980403093325 580 3121976
SGTC_695 3505-6186 243 µM -0.100574447982833 0.469505667714042 no 1798 0.459944140694736 601 1819379
SGTC_844 0330-0132 15.3 µM -0.101284797965053 0.469182719647984 no 1799 0.459662191799238 594 2828079
SGTC_2297 7971671 152.32 µM -0.1022937717383 0.468724042453868 no 1800 0.459261749404516 598 909016
SGTC_1474 0330-0125 5.35 µM -0.102809481429923 0.468489617987279 no 1801 0.459057090025426 590 X1474
SGTC_2764 methyldopa 94.69 µM -0.103484847619638 0.468182635523718 no 1802 0.45878908738675 611 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_696 1560-0013 611 µM -0.10361260457183 0.468124566714309 no 1803 0.458738392251988 603 1650269
SGTC_773 4358-1457 44.6 µM -0.105619843464527 0.467212315016405 no 1804 0.457941990003859 635 1186886
SGTC_489 paxilline 115 µM -0.106505508931899 0.466809851461893 no 1805 0.45759064238805 630 105008 A toxic potassium channel blocker.
SGTC_2725 haloperidol 53.21 µM -0.106510178434894 0.46680772963879 no 1806 0.457588790062049 594 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2724 maprotiline 69.64 µM -0.106714740568771 0.466714777490523 no 1807 0.457507644052475 577 4011 A tricyclic antidepressant.
SGTC_3306 9127676 59.7925 µM -0.107252581469539 0.466470393587256 no 1808 0.457294300989154 598 41905287
SGTC_2197 6588183 93.1375 µM -0.10738522882292 0.466410123283036 no 1809 0.457241686216942 600 884136
SGTC_2340 7987427 183.45 µM -0.10740454563535 0.466401346465306 no 1810 0.457234024236735 592 2239331
SGTC_3033 9090887 49.47 µM -0.107745598429339 0.466246387868235 no 1811 0.457098748857045 588 19325384
SGTC_2105 5350118 200 µM -0.107828391145401 0.466208771462728 no 1812 0.457065910654951 604 2133313
SGTC_74 000s-0487 160.283 µM -0.108300586978317 0.465994237718767 no 1813 0.456878628507339 598 677548
SGTC_2515 chrysin 20.77 µM -0.108905626015711 0.465719363487881 no 1814 0.456638672137395 608 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_316 k060-0003 58.6 µM -0.10931248897266 0.465534531474897 no 1815 0.456477320594575 616 6152314
SGTC_1540 guanosine 70.6 µM -0.109780031103977 0.465322142965335 no 1816 0.456291914090953 591 6802 Guanosine is a purine nucleoside
SGTC_2769 toremifene 3.73 µM -0.109788012664586 0.465318517299037 no 1817 0.456288749039987 596 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2571 chrysanthemic acid 100 µM -0.110474369464232 0.465006746877899 no 1818 0.456016587818599 638 2743 An insecticide.
SGTC_866 0495-0101 262 µM -0.110482516996829 0.465003046074781 no 1819 0.456013357199287 608 635694
SGTC_1471 k673-0312 37 µM -0.111485264338331 0.464547597590768 no 1820 0.455615775054276 588 24099884
SGTC_3014 9081533 49.47 µM -0.111491813256392 0.46454462322001 no 1821 0.455613178600779 615 21367265
SGTC_1091 telmisartan 47.6 µM -0.111503249933499 0.464539428944173 no 1822 0.455608644299049 585 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_352 k048-0007 5.11 µM -0.111734654564486 0.464434331579668 no 1823 0.455516900500234 615 6811911
SGTC_1597 7-benzyloxygramine 47.5 µM -0.112844203100853 0.463930440971969 no 1824 0.455077036562877 601 260807
SGTC_1879 gemcitabine 100 µM -0.114282398831659 0.463277384668683 no 1825 0.454506967388343 592 60750 A nucleoside analog which inhibits DNA replication.
SGTC_703 3875-0075 71.8 µM -0.115502246048338 0.462723553602973 no 1826 0.454023520151997 599 2850814
SGTC_1713 st033146 12.748 µM -0.11572528114909 0.462622299713398 no 1827 0.453935134702722 625 674619
SGTC_2394 5221648 200 µM -0.116398094218579 0.462316869484754 no 1828 0.453668522860951 616 788586
SGTC_1097 itavastatin 7.23 µM -0.118611659826304 0.461312156977134 no 1829 0.452791513681726 593 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1215 3852-0577 11.2 µM -0.120039666556542 0.460664131398557 no 1830 0.452225862878696 588 2884876
SGTC_1828 st055811 49 µM -0.120317494566957 0.46053806588562 no 1831 0.452115823061734 643 5877589
SGTC_2488 5268135 45.7 µM -0.120692685239176 0.460367827992825 no 1832 0.451967226487462 615 1270356 YLR208W SEC13
SGTC_743 1275-0778 158 µM -0.121962826154934 0.459791572158892 no 1833 0.451464229430556 622 2849257 YMR203W TOM40
SGTC_170 4197-0004 226 µM -0.122240802679605 0.459665466985681 no 1834 0.451354156439193 618 218692
SGTC_1078 idebenone 36.1 µM -0.122573814225135 0.459514400296301 no 1835 0.451222295635555 595 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_236 1509-0011 5.31 µM -0.12309711298563 0.459277023914159 no 1836 0.451015098699117 623 3107280
SGTC_1496 4469-0713 57.4 µM -0.123672668281832 0.459015959929909 no 1837 0.450787226522041 633 746691
SGTC_1745 st081495 74 µM -0.126059281161836 0.457933614916188 no 1838 0.449842499602156 596 13842402 YBL026W LSM2
SGTC_3352 9151559 45.5865 µM -0.126187937965688 0.457875276976681 no 1839 0.449791579574973 586 17159339
SGTC_2458 5808907 16.39 µM -0.12713548627655 0.457445650191694 no 1840 0.449416582675186 594 2731747
SGTC_22 0964-0034 14.468 µM -0.127721338293081 0.457180044549551 no 1841 0.449184751438528 604 138402
SGTC_810 3825-7150 143 µM -0.128032387911092 0.457039032857548 no 1842 0.449061671055845 598 22330411 YGL099W LSG1
SGTC_54 0159-0055 9 µM -0.128501433425823 0.456826405306638 no 1843 0.448876081960023 667 3319099
SGTC_2832 7992762 51.95 µM -0.129998026275217 0.456148053282044 no 1844 0.448283994122288 599 2985177
SGTC_88 0180-0332 8.668 µM -0.130214837687694 0.456049790972751 no 1845 0.448198227875775 596 3101745
SGTC_1749 st037932 54.2 µM -0.130588763568597 0.455880328258082 no 1846 0.448050315987847 621 594497
SGTC_1966 st070145 16.1 µM -0.131127502726289 0.455636186504093 no 1847 0.447837222485895 600 3748532
SGTC_3096 9117468 49.47 µM -0.131421637472099 0.455502899799033 no 1848 0.44772088644141 614 41316311
SGTC_2926 9010726 65.15 µM -0.1317881022966 0.455336843839424 no 1849 0.447575948729031 646 2994293
SGTC_719 2810-4230 27.3 µM -0.131912192778106 0.45528061656996 no 1850 0.447526872232988 600 721079
SGTC_1860 st056228 74.6 µM -0.132968983214899 0.45480180529115 no 1851 0.447108955223734 603 688679
SGTC_3009 9080819 71.4286 µM -0.133601338074478 0.454515328907128 no 1852 0.446858913022974 627 17027216
SGTC_2936 9038235 15.59 µM -0.134194205920936 0.454246762850766 no 1853 0.446624503739071 594 4749415
SGTC_668 1682-0499 62.6 µM -0.135363982710284 0.453716921504494 no 1854 0.446162049809645 607 682214
SGTC_1424 4048-1941 275 µM -0.135571010276857 0.453623158521637 no 1855 0.44608021213564 601 X1424
SGTC_2605 digitonin 300 nM -0.135931577819831 0.453459863311348 no 1856 0.445937685834386 598 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3047 9092122 49.47 µM -0.136638538650689 0.45313971504537 no 1857 0.445658256369138 628 17173831
SGTC_2722 naftopidil 47.16 µM -0.137511232750076 0.452744556245119 no 1858 0.445313357318858 640 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2877 9040724 71.43 µM -0.13816555336474 0.452448308362372 no 1859 0.445054789192065 622 6463895
SGTC_1234 0326-0494 15.5 µM -0.138400204547732 0.452342074964158 no 1860 0.444962067683317 625 1547813
SGTC_1400 3771-8998 51.5 µM -0.138557978636649 0.452270647974506 no 1861 0.444899725554064 604 670767
SGTC_848 0368-0089 85.6 µM -0.138644653756841 0.452231409343759 no 1862 0.444865477724841 626 762535
SGTC_3283 9109332 35.8195 µM -0.138705393115829 0.452203912350657 no 1863 0.444841478104964 594 17027281
SGTC_1045 1348-1485 165 µM -0.138875613591433 0.452126853963753 no 1864 0.444774220871345 610 6810614
SGTC_3190 9110366 49.47 µM -0.139575103288712 0.451810215676663 no 1865 0.444497856367119 628 17123768
SGTC_1846 st056244 14.8 µM -0.140804389013165 0.451253828796127 no 1866 0.444012237840775 628 5393182
SGTC_1963 st076565 50.3 µM -0.141552250107575 0.450915386242319 no 1867 0.443716842959135 605 4914280
SGTC_2929 9013348 24.6 µM -0.143008191193705 0.450256606539971 no 1868 0.443141856026446 622 2995952
SGTC_249 wiskostatin 11.211 µM -0.144344292711689 0.449652172009375 no 1869 0.442614301989178 616 2775510 A n-wasp and actin depolymerizer.
SGTC_636 0kpi-0074 126 µM -0.14527861167491 0.449229567863368 no 1870 0.442245450485071 614 616434
SGTC_1519 esterone 74 µM -0.145817563711181 0.448985819279439 no 1871 0.442032705134667 617 698 A steroid.
SGTC_747 3448-8087 38.7 µM -0.146162143686373 0.448829988257786 no 1872 0.441896694761601 647 5168703
SGTC_37 0566-0070 1.56 µM -0.147610918705069 0.448174888562608 no 1873 0.441324918811873 637 1626686
SGTC_2642 cholecalciferol 100 µM -0.148249359793139 0.447886246279648 no 1874 0.441072989335618 633 9821465 A vitamin D precursor, similar to steriods.
SGTC_2563 tomatine 8.54 µM -0.149736846535142 0.447213853668094 no 1875 0.440486118280149 628 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_666 0272-0154 136 µM -0.150312637931999 0.446953617760066 no 1876 0.440258981321294 611 6870312
SGTC_2980 9014342 25.29 µM -0.150337241603931 0.446942498340038 no 1877 0.440249276154815 614 2996599
SGTC_2653 dihydrofissinolide 100 µM -0.150791855868904 0.446737046808709 no 1878 0.440069955439771 609 6857746
SGTC_1783 st039459 87.517 µM -0.151765673549528 0.446297002473441 no 1879 0.439685878500285 616 729761
SGTC_3314 9135860 59.4275 µM -0.151772726878592 0.446293815487529 no 1880 0.439683096850402 603 25252478
SGTC_9 0092-0002 10.449 µM -0.152875857215918 0.44579541838887 no 1881 0.439248087619741 616 759368
SGTC_1488 4013-0813 75.9 µM -0.153265749476654 0.445619284514543 no 1882 0.439094354736554 617 2910057
SGTC_2987 9018338 71.43 µM -0.154330421270156 0.445138373675308 no 1883 0.438674605972831 623 5055682
SGTC_270 tamoxifen 5.46 µM -0.155103933745232 0.444789029704724 no 1884 0.438369690518909 624 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2315 7733312 200 µM -0.155597357980478 0.444566205285673 no 1885 0.438175203802027 624 726316
SGTC_359 0081-0058 15.9 µM -0.15697808347385 0.443942779659154 no 1886 0.437631060397532 602 3494159
SGTC_1445 4239-0156 97.7 µM -0.157676922358516 0.443627292463586 no 1887 0.437355693137701 654 4008346
SGTC_1964 st076914 61 µM -0.158048232152249 0.443459681101229 no 1888 0.437209396269331 623 24208661
SGTC_2635 hydroquinidine 100 µM -0.15859573969933 0.443212551528746 no 1889 0.436993692770255 602 442912 An experimental heart treatment.
SGTC_876 0720-0963 56.8 µM -0.158684603566692 0.443172442948771 no 1890 0.436958684520781 684 765861
SGTC_714 4296-0578 26.1 µM -0.158833440512087 0.443105266909952 no 1891 0.436900050761193 602 1589775
SGTC_790 1575-0012 79.1 µM -0.160441946661228 0.442379388779292 no 1892 0.43626647446106 649 378741 YLR208W SEC13
SGTC_76 0433-0009 400.328 µM -0.161464065680233 0.441918232666258 no 1893 0.435863955698741 691 2841569
SGTC_281 1672-3440 14.9 µM -0.162150241125272 0.441608690527134 no 1894 0.435593771480518 617 6833000
SGTC_151 3013-0144 2.285 µM -0.162461460116805 0.441468307575135 no 1895 0.435471237708061 645 906558 YHR107C CDC12
SGTC_2295 7971645 200 µM -0.16382254692448 0.440854442644666 no 1896 0.434935420797526 636 2978226 YKL099C UTP11
SGTC_1986 st071812 45 µM -0.165296538749862 0.440189816626437 no 1897 0.434355291512447 622 11838594
SGTC_1133 3473-0247 50 µM -0.165626030573584 0.440041271044421 no 1898 0.434225630391697 603 711311
SGTC_2200 6600604 21.907 µM -0.165660307942749 0.440025818180907 no 1899 0.434212142019678 652 2904777
SGTC_326 k292-0812 17.5 µM -0.166151206856534 0.439804522027048 no 1900 0.434018978453097 650 3579357
SGTC_2882 9058044 58.44 µM -0.1677408163004 0.4390880589686 no 1901 0.433393592170294 640 18076804
SGTC_2055 5235184 200 µM -0.168113775607048 0.438919988899423 no 1902 0.433246886110889 638 2836034
SGTC_3345 9148410 3.559 µM -0.168515842331543 0.438738814223503 no 1903 0.43308874075581 628 4903596
SGTC_3031 9088762 49.47 µM -0.168564775485283 0.438716765404803 no 1904 0.433069494554511 624 205253
SGTC_1290 0986-0249 10.2 µM -0.169552424040872 0.438271781007327 no 1905 0.432681070392436 630 53329
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.170217302736728 0.437972264266633 no 1906 0.432419622335881 613 676296 Flavone; oxidizing agent.
SGTC_1761 st044296 37 µM -0.17212889753016 0.437111321279333 no 1907 0.431668097432464 636 1826700
SGTC_338 4055-0136 114 µM -0.173868155231865 0.43632825393602 no 1908 0.430984539922907 613 2900563
SGTC_687 k029-0044 34.9 µM -0.176091549382023 0.435327577172214 no 1909 0.430111009902856 622 5829338
SGTC_2917 7979103 53.79 µM -0.177303269436353 0.434782395612443 no 1910 0.429635091421478 663 2980565
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.178301900149648 0.434333181139541 no 1911 0.42924294331114 659 6728940
SGTC_2841 9004761 38.96 µM -0.179775210483212 0.433670596293307 no 1912 0.428664522845922 621 2991039
SGTC_1271 0832-2808 169 µM -0.181906952603556 0.432712228408716 no 1913 0.427827874072787 656 3663794
SGTC_959 1222-0044 107 µM -0.182341577594057 0.432516882310134 no 1914 0.42765733568773 644 6083612
SGTC_2306 7482397 179.52 µM -0.184224852041309 0.43167061889733 no 1915 0.426918532011987 664 891448
SGTC_2271 7849410 118.62 µM -0.185359296987234 0.43116099865231 no 1916 0.42647361572939 617 972430
SGTC_1196 1588-0294 184 µM -0.186239406183608 0.430765711093573 no 1917 0.426128511418177 655 6144269
SGTC_1023 4482-3888 16 µM -0.187362778639188 0.430261266375444 no 1918 0.4256881020604 654 3303168
SGTC_1075 aripiprazole 15.2 µM -0.187791096781738 0.430068962201401 no 1919 0.425520207670731 630 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3134 9127454 49.47 µM -0.188004568353947 0.429973124975152 no 1920 0.425436535005843 626 24262820
SGTC_1672 st016598 6.51 µM -0.188229025003998 0.429872360491011 no 1921 0.425348560233701 675 4665860 YNL267W PIK1
SGTC_2597 laccaic acid a 100 µM -0.190444090287632 0.428878205499107 no 1922 0.424480575384974 653 5491415 A textile dye.
SGTC_1859 st055998 20 µM -0.191227959181079 0.428526500941563 no 1923 0.424173499768013 661 676301
SGTC_476 mead acid 10 µM -0.191228548730705 0.428526236445068 no 1924 0.424173268833023 629 5312531 An omega 9 fatty acid.
SGTC_1645 Cervolide 78 µM -0.19150420110311 0.428402570838849 no 1925 0.424065294723623 630 23173 A fragrance.
SGTC_362 0310-0100 9.03 µM -0.19161806515241 0.428351490192712 no 1926 0.424020695394396 642 790235
SGTC_2395 5646831 180.19 µM -0.192304713077522 0.428043477970248 no 1927 0.42375176339975 662 6808628
SGTC_1516 st013856 110 µM -0.193088717765548 0.427691847672813 no 1928 0.423444744155638 656 5281404 A mutagen and neurotoxin.
SGTC_2956 9076196 2.52 µM -0.193196404838011 0.4276435539238 no 1929 0.423402577110884 660 16423868
SGTC_3323 9138564 53.9225 µM -0.19348605361374 0.427513662327133 no 1930 0.423289163646388 632 43912313 YNL103W MET4
SGTC_2814 7977482 42.97 µM -0.193487004988302 0.427513235700736 no 1931 0.423288791141263 624 6456762
SGTC_275 trichlorophene 5.69 µM -0.193854165407866 0.427348595707241 no 1932 0.423145036757252 641 62616
SGTC_900 1112-0045 141 µM -0.194117821107991 0.427230376516361 no 1933 0.423041813904802 634 56211 YIL048W NEO1
SGTC_641 4092-0595 30 µM -0.19464095824159 0.426995829168055 no 1934 0.422837018098137 629 786260
SGTC_904 1141-0088 396 µM -0.195021166967879 0.426825379636686 no 1935 0.422688188461852 670 1378119
SGTC_798 1287-0182 476 µM -0.195741342748729 0.426502558598183 no 1936 0.422406311730948 664 1649755
SGTC_1122 capsaicin 818.572 nM -0.197639233813975 0.425652059388232 no 1937 0.42166366804321 652 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1941 st076221 61.8 µM -0.1981849611419 0.425407567217789 no 1938 0.4214501766952 617 2828568
SGTC_2606 farnesol 9.78 µM -0.198676747353663 0.425187265858689 no 1939 0.421257807167014 622 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1361 1608-0041 5.61 µM -0.199067105320909 0.425012417088083 no 1940 0.421105126190751 628 X1361
SGTC_1227 3909-8010 46.6 µM -0.199497803804048 0.424819516148845 no 1941 0.420936680568478 624 15982272
SGTC_2584 androsterone 48.74 µM -0.201247950239031 0.424035847442801 no 1942 0.420252349759255 648 2754130 A steroid.
SGTC_936 3005-4620 401 µM -0.202493679380404 0.423478226042418 no 1943 0.419765399595339 679 777207
SGTC_1704 st028805 70.8 µM -0.202730489589495 0.423372240810743 no 1944 0.419672845373858 630 2876101
SGTC_607 4491-0986 66.8 µM -0.203183090377118 0.423169693186672 no 1945 0.419495964548502 635 698981 YDR232W HEM1
SGTC_103 0844-0104 51.839 µM -0.204117614944704 0.422751539634177 no 1946 0.419130794688592 639 5375804
SGTC_676 falcarinol 140 µM -0.204176614658345 0.422725143094221 no 1947 0.419107742607883 653 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2950 9072895 21.46 µM -0.204361365142476 0.422642487759393 no 1948 0.419035559595287 652 17332245
SGTC_72 0744-0168 198.391 µM -0.205420949519358 0.422168507250195 no 1949 0.41862162696089 701 677577
SGTC_950 1165-0508 94.1 µM -0.205810439448372 0.421994306250211 no 1950 0.418469493135664 647 6148369
SGTC_945 3381-0768 11.3 µM -0.206872554122032 0.42151934866497 no 1951 0.418054695743201 660 1126236 YIL048W NEO1
SGTC_732 3970-1727 52.7 µM -0.206962145445118 0.42147929033178 no 1952 0.418019710982911 660 1275699
SGTC_1076 itraconazole 331 nM -0.207471265704728 0.421251666441406 no 1953 0.417820915548147 626 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2778 tioconazole 65.09 nM -0.207777362270944 0.421114825600648 no 1954 0.417701404578518 655 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_549 1661-1316 519 µM -0.208227314460684 0.4209136912322 no 1955 0.417525741065995 663 2857282
SGTC_3104 9120930 49.47 µM -0.208368871037026 0.420850417902802 no 1956 0.417470480095137 673 17014836
SGTC_382 3229-0966 23.2 µM -0.209346527289347 0.420413478456983 no 1957 0.417088866415337 668 5722370
SGTC_2108 5365811 200 µM -0.20956255013684 0.420316945559299 no 1958 0.417004555609445 618 780283
SGTC_2266 7929956 200 µM -0.209704106498718 0.420253691674179 no 1959 0.416949310138966 634 2967153
SGTC_2038 4100038 30.985 µM -0.211059887073104 0.419647971188584 no 1960 0.416420270300296 645 3596803
SGTC_2188 6126565 140.678 µM -0.211352707631049 0.419517173037462 no 1961 0.416306028483185 664 874518
SGTC_1027 k015-0025 8.67 µM -0.212970016553452 0.4187949081745 no 1962 0.415675174753261 629 3598955
SGTC_166 k072-0058 166.424 µM -0.21302018602894 0.418772507634948 no 1963 0.415655608920984 632 5846229
SGTC_3246 9135460 32.98 µM -0.214418783357355 0.418148143849535 no 1964 0.415110247635037 630 41446951
SGTC_2034 5197015 53.07 µM -0.215434831145394 0.417694687594494 no 1965 0.414714158085045 683 780676
SGTC_3340 9146634 11.102 µM -0.216185031309394 0.417359947780839 no 1966 0.414421760479905 651 4907387
SGTC_586 0957-0265 8.15 µM -0.218606046743976 0.41628009872332 no 1967 0.41347847105379 651 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_381 3461-2219 42.7 µM -0.21896130462498 0.41612169547834 no 1968 0.413340095379418 685 2883159
SGTC_1044 1222-0021 1.78 µM -0.218976990745453 0.4161147016268 no 1969 0.413333985762962 661 4306703
SGTC_3249 9135183 49.47 µM -0.219633580398742 0.415821976831779 no 1970 0.413078268269878 675 4902779
SGTC_125 0133-0007 11.75 µM -0.220157161792189 0.415588584047867 no 1971 0.412874379017404 659 26541
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.220572935827156 0.415403268913217 no 1972 0.412712488059364 649 6857784
SGTC_1816 st051957 91.6 µM -0.220839352240403 0.415284534028501 no 1973 0.412608760648268 649 674121
SGTC_179 1273-0063 6.77 µM -0.221894650047298 0.414814291282716 no 1974 0.412197947684239 686 3108139
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.222206070019411 0.414675545230423 no 1975 0.412076734520964 680 6708760
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.223017336044019 0.41431415421396 no 1976 0.411761007028355 662 688667
SGTC_629 3448-6466 76.7 µM -0.224122924467343 0.413821769555652 no 1977 0.411330827513122 673 573744
SGTC_2053 5265679 138 µM -0.224362050639896 0.413715290157839 no 1978 0.411237798589714 622 764595
SGTC_409 arachidonic acid 100 µM -0.224782081269733 0.413528272006334 no 1979 0.411074403228936 655 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2812 7970281 58.44 µM -0.224897062555818 0.413477080139797 no 1980 0.411029677253663 669 2233435
SGTC_1715 st032160 10.2275 µM -0.225800819023704 0.413074761761288 no 1981 0.41067817001942 671 5289825
SGTC_2992 9074591 71.4286 µM -0.226753752478648 0.412650650499933 no 1982 0.410307613567432 641 17741321
SGTC_284 0988-0104 32.6 µM -0.226972962214265 0.412553103720809 no 1983 0.410222383272765 648 4666532
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.227825174762623 0.412173926539659 no 1984 0.409891077333749 631 17037758
SGTC_875 0709-0210 25.7 µM -0.228014503452408 0.412089699141255 no 1985 0.409817482683017 653 6251364
SGTC_2290 7904846 200 µM -0.228204074502047 0.412005367980399 no 1986 0.409743797006789 658 2962154
SGTC_2016 5121758 140 µM -0.228925183433714 0.411684618007733 no 1987 0.409463533358417 670 2795203
SGTC_1502 4534-4282 27.7 µM -0.229354960042106 0.411493480992535 no 1988 0.409296519894473 683 3278949
SGTC_1405 3909-7894 12 µM -0.230779049036951 0.410860288067824 no 1989 0.408743229184317 641 7104060
SGTC_3098 9119039 49.47 µM -0.231225200186234 0.410661963500703 no 1990 0.4085699267467 624 17161528
SGTC_101 0490-5701 117.494 µM -0.231252707786406 0.410649736479344 no 1991 0.408559242310987 643 4661669
SGTC_794 k038-0031 316 µM -0.232802976222467 0.409960788869768 no 1992 0.407957200863979 637 6624242
SGTC_2581 avocatin a 64 µM -0.234606680559986 0.409159562814966 no 1993 0.407257011961236 696 6710728 A skin care supplement.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.234674733654582 0.409129340259474 no 1994 0.407230599879703 652 688788
SGTC_1901 st060216 58.6 µM -0.234704807857977 0.409115984399982 no 1995 0.407218927917223 635 688792
SGTC_191 3914-0123 66.505 µM -0.235066201854404 0.408955498714599 no 1996 0.407078675381047 677 3144412
SGTC_975 1335-0046 28.5 µM -0.235410811707319 0.408802480645772 no 1997 0.406944947659959 689 16486740
SGTC_3112 9123419 49.47 µM -0.236645541283025 0.408254334525085 no 1998 0.406465893329946 654 17015854
SGTC_2621 lithochol-11-enic acid 100 µM -0.237318978054026 0.407955444426474 no 1999 0.406204670117093 683 6708711
SGTC_92 0063-0024 660.874 µM -0.238905816546823 0.407251373136748 no 2000 0.405589307597174 650 3594437
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.243556049450162 0.405189824244551 no 2001 0.403787335379148 640 97141
SGTC_2010 4012422 159 µM -0.2436237696138 0.405159821706691 no 2002 0.403761108693771 663 952393
SGTC_2337 9009472 200 µM -0.243646732321669 0.40514964850411 no 2003 0.403752215787577 663 5742383
SGTC_2569 tetrandrine 100 µM -0.244759688615016 0.404656650782163 no 2004 0.403321254228722 648 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2896 9052656 71.43 µM -0.245627423744167 0.404272381737722 no 2005 0.40298532919718 674 6469436
SGTC_1431 4049-0260 9.09 µM -0.246341083411778 0.403956412869355 no 2006 0.402709104815357 654 3854841
SGTC_1485 3909-9022 254 µM -0.246547244166892 0.403865147991119 no 2007 0.402629318633379 657 714516
SGTC_2383 9036125 200 µM -0.24682726347171 0.40374119520659 no 2008 0.4025209549824 660 79580
SGTC_3208 9114115 49.47 µM -0.247238064208175 0.403559368471858 no 2009 0.402361994256863 696 650895
SGTC_2399 5884133 200 µM -0.247393563425051 0.403490547558688 no 2010 0.402301827523033 671 722445
SGTC_1712 st032288 53.4 µM -0.247547541033165 0.403422403024472 no 2011 0.402242251820296 662 2883011
SGTC_439 amiodarone 34.4 µM -0.247697944268155 0.403355843200414 no 2012 0.402184061275843 656 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2497 7-hydroxyflavone 100 µM -0.248530422478826 0.402987486889795 no 2013 0.401862017281745 668 5281894
SGTC_1248 0469-0687 58.6 µM -0.248658811988891 0.402930684544438 no 2014 0.40181235575543 671 4017482
SGTC_2854 9024559 71.43 µM -0.249316255278543 0.402639849289448 no 2015 0.40155807917783 687 3163529
SGTC_2908 7930301 100 µM -0.249483731157018 0.402565771061765 no 2016 0.401493311892544 673 2223178
SGTC_1386 3228-0095 33.8 µM -0.2495061697439 0.402555846251903 no 2017 0.401484634511959 693 870181
SGTC_53 0973-0023 39.979 µM -0.249688567454839 0.402475172263316 no 2018 0.401414100038879 684 674768
SGTC_2948 9070189 9.45 µM -0.249912058721127 0.402376328374548 no 2019 0.401327678779522 663 6473636 YDL196W YDL196W
SGTC_3114 9122766 49.47 µM -0.250436033587462 0.402144613538121 no 2020 0.401125083225381 647 17176985
SGTC_531 3788-1495 174 µM -0.250552229468591 0.402093233458548 no 2021 0.401080159538249 627 2896655
SGTC_2495 cafestol 54.53 µM -0.25098204113732 0.401903191881351 no 2022 0.400913996990168 688 16667697 An anti-infammatory.
SGTC_2083 5306046 65.942 µM -0.252715103937693 0.401137152484218 no 2023 0.400244187703665 663 539837
SGTC_2643 anethole 100 µM -0.253134971336526 0.40095162193876 no 2024 0.400081957738459 686 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2119 5528445 120.635 µM -0.253342515590638 0.400859920758355 no 2025 0.40000177236485 659 791935
SGTC_358 0075-0058 9.45 µM -0.254979836850656 0.400136680016631 no 2026 0.399369336245817 744 1069125
SGTC_3344 9148862 3.898 µM -0.255109855144853 0.400079262722695 no 2027 0.39931912632191 693 4905352
SGTC_2596 sinensetin 100 µM -0.256102445978916 0.399640996606147 no 2028 0.398935866668713 659 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.256124837870648 0.399631111201368 no 2029 0.398927221822887 646 6312947
SGTC_117 lucigenin 22.078 µM -0.256208087123445 0.399594359508583 no 2030 0.398895082188273 692 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_933 2914-0560 114 µM -0.256631007183186 0.39940766853828 no 2031 0.398731818086665 665 463887
SGTC_2059 5238311 157 µM -0.258165061075211 0.398730679486542 no 2032 0.398139760672091 646 703021
SGTC_207 4185-0010 4.486 µM -0.258310291158846 0.398666604153622 no 2033 0.39808372226 647 3761753
SGTC_1370 2001-0092 44.6 µM -0.259540737533089 0.398123842501276 no 2034 0.397609027263399 658 790957
SGTC_1666 st014829 29 µM -0.259659976251746 0.398071255620583 no 2035 0.397563034097574 664 3858230
SGTC_3346 9158254 43.5805 µM -0.260094246497171 0.397879748609737 no 2036 0.39739553793708 670 17639500
SGTC_367 0335-0881 7.1 µM -0.260903972967996 0.397522736473049 no 2037 0.39708328047436 699 23828853
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.262580345186921 0.396783889301644 no 2038 0.396437025435509 681 551469
SGTC_614 0462-0418 107 µM -0.262637082251078 0.396758889375835 no 2039 0.396415157805002 653 5188303
SGTC_1456 k015-0012 13 µM -0.262771091713845 0.396699842770641 no 2040 0.39636350909794 678 2989616
SGTC_1032 k061-1018 98.7 µM -0.263127324265091 0.396542892816902 no 2041 0.396226222036821 695 4005393
SGTC_1102 cgs 12066b 26.1 µM -0.263363208609066 0.39643897544226 no 2042 0.396135322578101 642 6438352 A 5-HT1B full agonist.
SGTC_1442 4112-3290 3 µM -0.263528172051245 0.396366306198775 no 2043 0.396071756272955 663 704353
SGTC_1237 0330-0133 46.1 µM -0.264003352076066 0.396157001326247 no 2044 0.395888667890355 696 X1237 YHR072W ERG7
SGTC_789 1309-1135 70.6 µM -0.264369635999555 0.395995682877042 no 2045 0.39574755319673 647 3092424
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.264932288462126 0.395747914666335 no 2046 0.395530812101746 637 2724 A muscle relaxant with antifungal properties.
SGTC_2418 pentamidine 31.67 µM -0.266094127118289 0.395236423738604 no 2047 0.395083358942387 684 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3252 9135871 49.47 µM -0.266647074169833 0.394993056184808 no 2048 0.394870453729702 687 17682838
SGTC_509 pifithrin 175 µM -0.267343956931217 0.394686396828128 no 2049 0.394602172622747 665 4817 A p53 inhibitor.
SGTC_126 0417-1624 672.48 µM -0.269510030568848 0.393733645605067 no 2050 0.393768612207018 693 41912 YDL195W SEC31
SGTC_2203 7227154 166.4 µM -0.270698902013324 0.393210988319083 no 2051 0.393311310679489 657 896304
SGTC_3234 9132280 49.47 µM -0.271321523944 0.392937345031971 no 2052 0.393071876712763 661 17612295
SGTC_171 k064-0041 9.68 µM -0.27202808631957 0.392626873875555 no 2053 0.392800211809356 640 53325
SGTC_252 miconazole 1.30953 nM -0.273337398293276 0.392051728740887 no 2054 0.392296934902631 679 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_872 0588-0139 234 µM -0.273435387125841 0.392008694379977 no 2055 0.392259276921074 637 2047100
SGTC_3274 9138298 49.47 µM -0.273573516860257 0.391948033334943 no 2056 0.392206194146936 670 17015756
SGTC_2343 7990716 14.84 µM -0.273584451778335 0.391943231269213 no 2057 0.39220199198181 638 6456862
SGTC_470 aa-861 153 µM -0.273632616499793 0.391922079943328 no 2058 0.392183482974691 657 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2699 st077704 54.6 µM -0.276799537985882 0.390532044036695 no 2059 0.390967017974449 668 645852
SGTC_1937 st074714 47.2 µM -0.27717568804358 0.390367035517077 no 2060 0.390822603343185 683 17250970
SGTC_139 0099-0334 718.624 µM -0.277233767178766 0.390341559273696 no 2061 0.390800306464118 671 97690
SGTC_3173 9105693 49.47 µM -0.277405737512248 0.390266127749753 no 2062 0.390734288273114 713 17096658
SGTC_2983 9022671 12.99 µM -0.278202257214453 0.389916803414588 no 2063 0.390428551113618 713 6405161
SGTC_114 0364-0001 490.298 µM -0.278274591778742 0.38988508452563 no 2064 0.390400789472868 675 4003655
SGTC_1843 st055809 45.5 µM -0.279057220971685 0.389541946577437 no 2065 0.390100456096822 670 16413835
SGTC_2774 tamoxifen 10.92 µM -0.279508836796789 0.389343978134964 no 2066 0.389927178688281 659 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1719 st032227 49.2 µM -0.27974149973351 0.38924200017825 no 2067 0.389837918360622 653 3125804
SGTC_2489 cantharidin 73.42 µM -0.28002714867507 0.389116808479975 no 2068 0.389728338081207 681 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3029 9088683 49.47 µM -0.28005744159595 0.389103532640683 no 2069 0.389716717663777 669 25236615
SGTC_2144 5628481 200 µM -0.280067803820152 0.389098991437029 no 2070 0.389712742719079 648 2818399
SGTC_2534 helenine 20.12 µM -0.280264647975532 0.389012728144697 no 2071 0.389637235578087 640 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2389 9091542 195.52 µM -0.281301185531572 0.388558575174286 no 2072 0.389239700543664 657 3626624 YOL127W RPL25
SGTC_736 0958-0254 92.6 µM -0.281691551353783 0.388387578077133 no 2073 0.389090016654718 710 6812352
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.282428946244266 0.388064626299168 no 2074 0.388807311072484 698 1273210
SGTC_1481 3346-2004 36 µM -0.282488030106813 0.388038753091683 no 2075 0.388784661796146 694 2770522
SGTC_1587 estradiol valerate 56.1 µM -0.282603858777646 0.387988032405997 no 2076 0.388740260996264 698 13791 A steroid.
SGTC_2285 7945142 200 µM -0.283322307433187 0.387673470729845 no 2077 0.388464889347274 704 2970608
SGTC_1063 disulfiram 1.84 µM -0.283486759124258 0.387601478450162 no 2078 0.388401865117201 660 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1317 1273-0028 910 nM -0.283517407998514 0.387588061670619 no 2079 0.388390119611383 681 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2435 5706476 10.6 µM -0.284399727572597 0.387201877132957 no 2080 0.388052033874702 650 5725375
SGTC_896 0964-0007 44.5 µM -0.284468138416536 0.387171938886804 no 2081 0.388025823862453 664 6756758
SGTC_698 k064-0052 127 µM -0.284929385533881 0.386970103475511 no 2082 0.387849121153185 674 5088751
SGTC_2431 5490079 200 µM -0.286946938624705 0.386087609789152 no 2083 0.387076474595284 718 5722345
SGTC_2241 6772625 37.8075 µM -0.287817459927373 0.385707018530109 no 2084 0.386743235777231 635 2285411
SGTC_372 0155-0182 15.9 µM -0.288784356932085 0.385284420843544 no 2085 0.386373201847342 668 771486
SGTC_759 3486-0358 89.3 µM -0.289619798021517 0.384919387699415 no 2086 0.386053559612084 674 875103
SGTC_1735 st034310 56.75 µM -0.289857412885173 0.384815584148975 no 2087 0.385962661577619 692 871153
SGTC_2762 leflunomide 42.06 µM -0.290074223787859 0.384720876143013 no 2088 0.385879727426365 662 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2044 5102272 200 µM -0.290172064811371 0.384678139178127 no 2089 0.385842303146074 660 592666
SGTC_63 0099-0242 26.702 µM -0.291831995660749 0.383953295241618 no 2090 0.385207540277145 690 3898502 YLR359W ADE13
SGTC_2891 9063876 19.48 µM -0.29402365788659 0.38299688143645 no 2091 0.384369912794564 668 6472478
SGTC_1146 3579-1023 7 µM -0.294103050248325 0.382962248953999 no 2092 0.384339580074431 670 X1146
SGTC_1358 1509-0022 2.48 µM -0.295537442967504 0.382336700534537 no 2093 0.383791676810317 675 3258434
SGTC_327 1273-0057 3.96 µM -0.295771736089889 0.382234552831097 no 2094 0.383702204549901 679 3108138
SGTC_1664 st014217 9.02 µM -0.296073421860711 0.382103035183137 no 2095 0.383587005401178 687 3982782
SGTC_2788 5282734 71.43 µM -0.297020574322156 0.381690219631082 no 2096 0.383225400766336 715 743706
SGTC_2779 methotrexate 400 µM -0.297625106767284 0.381426805005943 no 2097 0.38299465503862 680 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_60 0986-0278 202 µM -0.298440294560301 0.381071687903205 no 2098 0.382683569411136 725 3110598
SGTC_626 0214-0009 33 µM -0.298631698972465 0.380988321645086 no 2099 0.382610538110468 691 3437874
SGTC_2170 morpholine 200 µM -0.299443933754484 0.380634614004042 no 2100 0.382300672381049 682 121171 Reacts with secondary amines.
SGTC_3311 9131146 2.8755 µM -0.301107713943891 0.379910391676405 no 2101 0.381666179484586 680 4900406 YPR165W RHO1
SGTC_2242 6630449 61.2675 µM -0.301380383340009 0.379791742241258 no 2102 0.381562225584376 690 691249 YDR170C SEC7
SGTC_2184 6075246 200 µM -0.303260530490502 0.378973923073519 no 2103 0.380845661396955 656 2267320
SGTC_976 1348-1067 47.6 µM -0.304306784700865 0.378519061702642 no 2104 0.38044708833808 660 5310671 YGL099W LSG1
SGTC_3095 9117207 49.47 µM -0.306240688478157 0.377678736040976 no 2105 0.37971069734378 684 17015229
SGTC_3093 9117344 49.47 µM -0.308143525855337 0.376852474109783 no 2106 0.378986561327573 665 24824913
SGTC_1700 st030840 7.9285 µM -0.308617650930601 0.376646684137767 no 2107 0.378806196192674 676 5499307
SGTC_829 1635-0120 117 µM -0.310100212153184 0.376003417388648 no 2108 0.378242375468186 684 285054
SGTC_3217 9129673 49.47 µM -0.310102883530431 0.376002258618206 no 2109 0.378241359772132 694 17248312
SGTC_329 k048-0121 21.3 µM -0.31026716998252 0.375930997794194 no 2110 0.378178897317295 680 6832902
SGTC_972 1319-0219 195 µM -0.311257024800557 0.375501728394018 no 2111 0.377802617457968 691 23903702
SGTC_1876 myriocin 605 nM -0.312594581753194 0.374921916203798 no 2112 0.377294347558119 710 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_222 nsc-310342 10.666 µM -0.312949744522765 0.374768005546685 no 2113 0.377159421833468 700 432556
SGTC_1082 camptothecin 424.86 nM -0.314301776443419 0.374182281875621 no 2114 0.376645924567227 650 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1594 piperine 70.1 µM -0.314351341320579 0.374160815019842 no 2115 0.376627104130582 697 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1769 st044406 64.4 µM -0.314897653010042 0.373924229903979 no 2116 0.376419681824472 703 670903
SGTC_2260 7964312 200 µM -0.315117075153754 0.373829220563046 no 2117 0.376336382193711 700 231951
SGTC_62 0180-0423 3.232 µM -0.315696151196569 0.373578518641563 no 2118 0.376116574159849 712 30102 YGL099W LSG1
SGTC_2984 9022109 38.96 µM -0.316434690044153 0.373258857415563 no 2119 0.375836294896499 703 6459207
SGTC_1002 4049-0206 172 µM -0.317081532893068 0.372978956533047 no 2120 0.375590868528987 670 4662749
SGTC_3132 9126706 49.47 µM -0.317109232201964 0.372966972024764 no 2121 0.375580359926678 730 850858
SGTC_724 3910-0327 137 µM -0.317308425314283 0.372880791853172 no 2122 0.375504792485919 725 2885483
SGTC_2998 9066762 71.4286 µM -0.317507508337958 0.372794665667232 no 2123 0.375429271581419 701 4945196
SGTC_3016 9080866 49.47 µM -0.317552652370178 0.372775136592368 no 2124 0.375412147137956 714 17066299
SGTC_654 1124-0271 80.9 µM -0.318420154163004 0.372399923374631 no 2125 0.375083126216184 694 5403748
SGTC_524 r073-0010 27.8 µM -0.319424563458564 0.371965645983351 no 2126 0.374702293362114 711 2772106
SGTC_1777 st045864 34.765 µM -0.319854222456006 0.371779923612136 no 2127 0.374539420704476 685 4691462
SGTC_931 2812-0076 566 µM -0.320242140017923 0.371612269823862 no 2128 0.374392390374807 676 3450959
SGTC_1087 pterostilbene 9.05 µM -0.321190955272626 0.37120230477159 no 2129 0.374032842985981 681 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2656 pseudo-anisatin 100 µM -0.321233202687553 0.371184053860215 no 2130 0.374016836147538 670 6708809 A neurotoxin.
SGTC_2666 tannic acid 100 µM -0.32145666657694 0.371087522130816 no 2131 0.373932173033805 685 16134267 A thiamine antagonist.
SGTC_420 mitomycin C 81.9 mM -0.322236648458662 0.370750649858418 no 2132 0.373636711250535 662 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1797 st048695 56.8 µM -0.324824307566245 0.369633756921414 no 2133 0.372657023245826 726 592262 YIL048W NEO1
SGTC_2065 5221596 34.26 µM -0.325178796704472 0.369480836676744 no 2134 0.372522877594013 682 788581
SGTC_56 0957-0365 83.25 µM -0.326940909590927 0.368720999652549 no 2135 0.371856289230712 688 6752360
SGTC_1048 3161-0300 24.5 µM -0.32696857399604 0.368709074624011 no 2136 0.371845827139764 662 2165101
SGTC_712 r015-0009 80.6 µM -0.326994218812919 0.368698020272824 no 2137 0.371836128898751 678 6813872 YLR060W FRS1
SGTC_1126 isoteolin 1.0172 µM -0.327224808687716 0.368598628014109 no 2138 0.371748929115382 672 133323
SGTC_2514 salinomycin 42.74 µM -0.327737352496714 0.368377735291922 no 2139 0.371555129305921 705 23682228 A polyether potassium ionophore.
SGTC_127 0180-0333 59.125 µM -0.329091426935262 0.367794374713912 no 2140 0.371043291995386 678 771601
SGTC_913 3487-1245 167 µM -0.330250154955506 0.367295415000653 no 2141 0.370605476249698 672 4016153
SGTC_1194 1488-0194 225 µM -0.330895418135569 0.367017655356436 no 2142 0.370361741502476 679 1391452
SGTC_1825 st052143 62.6 µM -0.331541411802516 0.366739650977955 no 2143 0.370117782952832 714 674173
SGTC_1778 st046819 58.9 µM -0.331677750860248 0.366680986179157 no 2144 0.370066301383651 677 671715
SGTC_1049 3226-0134 66 µM -0.331688070544608 0.366676545889382 no 2145 0.370062404770065 693 5702385
SGTC_493 zm226600 134 µM -0.331946158802411 0.366565503078997 no 2146 0.369964957464471 731 5240098 A potassium channel opener. YCR052W RSC6
SGTC_18 0111-0177 500 nM -0.332662634851715 0.366257296884778 no 2147 0.36969447881615 719 721752
SGTC_2806 7952793 58.44 µM -0.332851817826076 0.366175930512493 no 2148 0.369623070635003 681 2972490
SGTC_2328 6201408 200 µM -0.33292388656642 0.366144935796385 no 2149 0.369595869064898 729 2890418
SGTC_1864 st057645 30.4 µM -0.334430590856946 0.365497145396582 no 2150 0.369027329396333 703 688666
SGTC_202 3594-0513 34.79 µM -0.334777536865932 0.365348034148673 no 2151 0.368896453345728 686 708429
SGTC_1465 k213-0056 144 µM -0.3357982760477 0.364909456624582 no 2152 0.368511495140717 696 24048857 YMR208W ERG12
SGTC_545 4218-0007 221 µM -0.336849877098501 0.364457803566145 no 2153 0.368115035766124 717 2840508
SGTC_43 0570-0105 72.5 µM -0.337056812985313 0.364368948621625 no 2154 0.368037036321489 712 1114046 YDL195W SEC31
SGTC_2102 5377816 72.7585 µM -0.337151666464372 0.364328222497654 no 2155 0.36800128542993 716 1379702
SGTC_3149 9097855 49.47 µM -0.337274953713974 0.364275290388973 no 2156 0.367954819374594 674 25236625 YMR079W SEC14
SGTC_2074 5212007 75.395 µM -0.337535907026654 0.364163261315574 no 2157 0.367856474368688 675 758611
SGTC_2907 7721985 69.9 µM -0.337631115843261 0.364122390397132 no 2158 0.367820595349468 684 3267881
SGTC_2735 sertaconazole 140 nM -0.339446462425497 0.363343400690172 no 2159 0.367136711035142 681 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_734 2023-0417 80 µM -0.339731333380366 0.363221209910919 no 2160 0.367029431549781 713 3935732
SGTC_2795 7780010 54.55 µM -0.339904177170791 0.363147078151996 no 2161 0.366964345407825 681 953673
SGTC_2441 5730946 39.09 µM -0.341533610533401 0.362448475386043 no 2162 0.366350953358616 676 1774275
SGTC_2669 eugenol 100 µM -0.34196521693215 0.3622635051814 no 2163 0.366188534395646 702 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2368 9071271 200 µM -0.342645934168463 0.361971840842027 no 2164 0.365932420590304 726 27209959
SGTC_2820 7989630 71.43 µM -0.342874489137455 0.36187393072176 no 2165 0.365846442205133 670 2984098
SGTC_1862 st057513 3.81 µM -0.343185842051783 0.361740565532971 no 2166 0.365729327521401 684 5393163
SGTC_2952 9073731 13.78 µM -0.344485363905832 0.361184108629707 no 2167 0.365240650582244 713 16457353
SGTC_1010 4112-3296 15.2 µM -0.346985332072635 0.360114445657696 no 2168 0.364301169155288 705 704384
SGTC_1942 st076330 65.2 µM -0.347682403889082 0.359816383838867 no 2169 0.364039356423761 735 24208414
SGTC_3250 9135583 49.47 µM -0.349570173735535 0.359009618360903 no 2170 0.363330649108644 693 7699353
SGTC_413 propylparaben 100 µM -0.35006412364586 0.358798625375957 no 2171 0.36314528731529 716 7175 A pharmaceutical preservative.
SGTC_3287 9117173 37.0625 µM -0.350320099080942 0.358689301229611 no 2172 0.363049241464472 680 2789709
SGTC_633 0437-0093 97.7 µM -0.350653190153069 0.358547059222006 no 2173 0.362924273557368 701 2831118
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.351654486505838 0.358119587461143 no 2174 0.362548698734508 707 15053
SGTC_962 1254-0300 21.5 µM -0.351746646981637 0.358080251392943 no 2175 0.362514137032804 694 7340576
SGTC_294 k038-0071 157 µM -0.352940256323936 0.357570929564075 no 2176 0.362066615113924 692 24152826
SGTC_3156 9099931 49.47 µM -0.354383851175533 0.356955275903349 no 2177 0.361525617605632 678 18111053
SGTC_3057 9095946 49.47 µM -0.35617054717192 0.356193814699334 no 2178 0.360856423749875 696 24540043
SGTC_3348 9149464 3.537 µM -0.356952942543466 0.355860550576969 no 2179 0.360563517231389 694 1951442
SGTC_656 4090-1979 187 µM -0.357053454340263 0.355817745192495 no 2180 0.360525894405931 712 22330961
SGTC_1581 himbacine 57.9 µM -0.357467226422047 0.355641549473942 no 2181 0.360371028552523 734 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_384 k007-0144 5.16 µM -0.357620426641799 0.355576320359302 no 2182 0.360313694865123 693 6824886
SGTC_2069 5228469 200 µM -0.357986353849347 0.355420534126614 no 2183 0.36017676289199 731 2835210
SGTC_1734 st037168 69.4 µM -0.358251401008647 0.355307710650503 no 2184 0.360077591987591 714 708907
SGTC_715 0868-0130 184 µM -0.358659036255879 0.355134215996288 no 2185 0.359925088241307 697 2876258
SGTC_2202 7226349 200 µM -0.359264072786968 0.354876760257675 no 2186 0.359698774201168 678 844334
SGTC_2893 9048488 25.97 µM -0.360075523741065 0.354531574887608 no 2187 0.359395328038181 688 6467338
SGTC_3184 9108758 49.47 µM -0.360766977727565 0.354237529594897 no 2188 0.359136825291904 708 902885
SGTC_1477 0139-0234 16 µM -0.36087721817529 0.354190657155127 no 2189 0.359095617430794 685 620880
SGTC_750 4073-0104 132 µM -0.36129650531405 0.354012403288013 no 2190 0.358938902946221 724 22330957
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.361988075807414 0.353718462000554 no 2191 0.358680470594326 725 165506
SGTC_991 3996-0057 64.7 µM -0.362084213010311 0.353677607275776 no 2192 0.358644550288787 694 715343
SGTC_450 aminopyrene 156 nM -0.36210214930069 0.353669985208016 no 2193 0.358637848786073 724 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1931 st074438 57.1 µM -0.362198540674137 0.35362902447748 no 2194 0.35860183500255 739 2787313
SGTC_2913 7966556 36.57 µM -0.363245044672336 0.353184430277552 no 2195 0.358210920747203 719 2976516
SGTC_1105 epirubicin 18.1 µM -0.36383322158553 0.352934638525292 no 2196 0.357991276565955 698 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.36420585593708 0.352776417924887 no 2197 0.357852147226861 714 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_3355 9151058 44.0485 µM -0.364362122963442 0.352710074498081 no 2198 0.357793807907079 693 17015728
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.364424497947421 0.352683594345202 no 2199 0.357770522321568 718 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_831 k061-1017 217 µM -0.364486981024077 0.352657069019178 no 2200 0.357747196913995 711 1240153
SGTC_474 dl-dihydrosphingosine 5 µM -0.364923346413563 0.352471843088858 no 2201 0.357584313210063 693 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_795 0685-0265 78 µM -0.365863754954859 0.352072782718963 no 2202 0.357233371686283 691 302754
SGTC_40 0327-0103 19.753 µM -0.368105663268466 0.35112209127791 no 2203 0.356397224125937 690 409036
SGTC_1710 st031758 61.5 µM -0.369084729046266 0.350707205675276 no 2204 0.356032285550844 722 5394341
SGTC_1362 1611-0397 101 µM -0.369657529165189 0.350464560324241 no 2205 0.355818840214774 698 27816
SGTC_520 3584-0023 682 µM -0.371079808269317 0.349862328953566 no 2206 0.355289044872378 691 1340790
SGTC_1984 st072354 53.1 µM -0.371490543484622 0.349688482759925 no 2207 0.355136099030863 697 5762938
SGTC_189 3970-0742 2.116 µM -0.372172860931571 0.349399757397621 no 2208 0.35488207546112 731 2891807
SGTC_1655 st012546 55.1 µM -0.374370626564251 0.348470357014232 no 2209 0.35406429665 715 720985 YLR208W SEC13
SGTC_2428 5615643 7.78 µM -0.374843712026948 0.348270415338253 no 2210 0.353888351509008 730 2253075
SGTC_566 0958-0068 16.5 µM -0.374898528453462 0.348247250814909 no 2211 0.353867966756583 732 6815365
SGTC_2662 daunorubicin 22.37 µM -0.374942105293965 0.348228836360269 no 2212 0.35385176200231 690 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_859 0439-0102 54.6 µM -0.378044154527244 0.346918911546318 no 2213 0.352698896573709 718 610143
SGTC_255 tunicamycin 200.472 nM -0.378150315077686 0.346874114614385 no 2214 0.352659466245096 725 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1016 4226-1401 38 µM -0.378227420398231 0.346841579559344 no 2215 0.352630828650721 714 2901613
SGTC_751 0833-0568 350 µM -0.378591887831582 0.346687805616395 no 2216 0.352495473546008 731 6954252
SGTC_1339 1486-1321 22.7 µM -0.379364575537489 0.346361881344939 no 2217 0.352208576289703 712 3469382
SGTC_2537 larixol 68.93 µM -0.379370247242184 0.346359489406338 no 2218 0.352206470708838 707 6708759
SGTC_2880 9042983 58.44 µM -0.381422332124565 0.345494462662183 no 2219 0.351444946304729 741 6464714
SGTC_1819 st053448 58.6 µM -0.382598102363537 0.344999196708733 no 2220 0.351008888746507 724 2857616
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.38291084053378 0.344867507658469 no 2221 0.350892936632652 703 803109
SGTC_432 NS 1619 61.3 µM -0.383521130714872 0.344610578333 no 2222 0.350666702882267 694 4552 A K+/calcium channel activator.
SGTC_2460 5552655 174.22 µM -0.384845488780296 0.344053276379753 no 2223 0.350175947333964 714 5401989
SGTC_2128 5255449 168.493 µM -0.386227923299108 0.34347189647152 no 2224 0.349663937674454 690 736008
SGTC_2903 5923464 63.88 µM -0.386586360757909 0.343321216727625 no 2225 0.349531228454989 726 2876576
SGTC_901 1112-0062 60.1 µM -0.387715086565315 0.342846886357051 no 2226 0.349113444998478 697 1908457
SGTC_554 4483-2211 187 µM -0.387981040876567 0.342735158998089 no 2227 0.349015031995851 704 747107
SGTC_1665 st014639 11.4 µM -0.388193207276333 0.342646037793812 no 2228 0.34893652980537 710 981133 YIL048W NEO1
SGTC_2150 5556613 200 µM -0.388240970242559 0.342625976007998 no 2229 0.348918858259169 714 743190
SGTC_2575 plumbagin 510 nM -0.389210181183656 0.34221897618455 no 2230 0.34856033629514 737 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2477 5967686 25.23 µM -0.390732957616319 0.34157988832181 no 2231 0.347997317494944 714 776118
SGTC_608 k048-0125 159 µM -0.392199340585042 0.34096489692462 no 2232 0.347455465658217 743 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2661 dactinomycin 12.96 µM -0.393124971478966 0.340576910721412 no 2233 0.347113590647433 701 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2326 6164455 177.58 µM -0.393192640378492 0.340548553326221 no 2234 0.347088602509464 717 2888790
SGTC_1756 st041558 35.5 µM -0.393446909873777 0.340442006960643 no 2235 0.346994714193168 755 3955792
SGTC_1524 corynanthine 62.1 µM -0.393854481283601 0.340271249170139 no 2236 0.34684423915937 744 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2438 5259590 200 µM -0.394576927068842 0.339968650808843 no 2237 0.346577572125194 721 1201127
SGTC_1494 4358-1428 177 µM -0.395182279398054 0.339715176710713 no 2238 0.346354184798851 740 1564571
SGTC_2680 butyl paraben 22.24 µM -0.395365580297214 0.339638438952586 no 2239 0.34628655357376 729 7184 An antifungal and steroid mimetic.
SGTC_3140 9094243 49.47 µM -0.395747181383231 0.339478705405379 no 2240 0.346145772668005 742 19291112
SGTC_514 4466-0038 2.65 nM -0.396785998194864 0.339044015546323 no 2241 0.345762638403749 724 5722064
SGTC_776 4476-4378 112 µM -0.398577209781717 0.338294991618222 no 2242 0.345102378494623 757 2892008
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.399788684505417 0.337788756278619 no 2243 0.344656082864992 732 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_248 streptozotocin 5.23457 mM -0.401117396279496 0.337233868692312 no 2244 0.344166846739493 750 5300 DNA alkylating agent.
SGTC_2447 5741742 33.78 µM -0.401495665145517 0.337075963277748 no 2245 0.344027614514214 715 1776504
SGTC_2086 5274770 176.623 µM -0.401564108547759 0.337047395174254 no 2246 0.344002424302357 720 689278
SGTC_884 0851-0618 334 µM -0.401997267668754 0.336866617450429 no 2247 0.343843018567251 747 9642473
SGTC_279 1273-0055 2.93 µM -0.402223589953059 0.336772177474706 no 2248 0.343759741343558 727 2847562
SGTC_1836 st055642 81 µM -0.404519572835714 0.335814690248206 no 2249 0.342915343916698 743 8571
SGTC_499 genistein 192 µM -0.404962806412959 0.335629972232065 no 2250 0.342752425325074 731 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.405272941727775 0.33550074665651 no 2251 0.342638446815382 767 5282309
SGTC_534 k292-0788 63.4 µM -0.406844288961194 0.334846305132246 no 2252 0.342061177896321 741 4146317
SGTC_1 0258-0098 57.368 µM -0.407364484207427 0.334629762293981 no 2253 0.341870153971465 692 6790032 YDR047W HEM12
SGTC_3045 9092950 49.47 µM -0.408515550464299 0.334150800923584 no 2254 0.34144760816289 732 44120432
SGTC_2927 9011802 47.9 µM -0.409455878994451 0.333759728307298 no 2255 0.34110256963251 734 43912568
SGTC_3048 9093155 49.47 µM -0.411521146907713 0.332901439493018 no 2256 0.34034521914139 716 25236002
SGTC_2701 st077767 14.721 µM -0.412037959628378 0.332686797933388 no 2257 0.340155800268063 729 5721188
SGTC_3193 9111931 49.47 µM -0.412354078985729 0.332555534936634 no 2258 0.340039958112151 731 17087244
SGTC_2720 fluspirilene 36.88 µM -0.412619296546651 0.332445423850035 no 2259 0.339942780602321 735 3396 An atypical antipsychotic.
SGTC_2391 6285546 200 µM -0.412626183356324 0.332442564827327 no 2260 0.339940257370258 705 846083
SGTC_2036 5160441 105 µM -0.41375842463944 0.331972653488394 no 2261 0.33952551735024 725 134534 YIL048W NEO1
SGTC_112 phenothiazine 287.218 µM -0.414465342852345 0.331679396845825 no 2262 0.339266671658145 760 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_838 0109-0203 71.4 µM -0.415479851743895 0.331258720080949 no 2263 0.338895330862825 707 759422
SGTC_175 3793-3120 23.7 µM -0.417227406609016 0.330534577451779 no 2264 0.338256040304236 776 5322297
SGTC_116 0155-0182 31.788 µM -0.417333670896834 0.330490564633597 no 2265 0.338217181712077 731 771486
SGTC_3078 9116413 49.47 µM -0.417376987972105 0.330472624127637 no 2266 0.338201342072431 710 17177322
SGTC_767 0929-0023 86 µM -0.417642891510151 0.330362504176676 no 2267 0.338104116108584 711 1204563
SGTC_894 0960-0238 55.9 µM -0.418015630756689 0.330208164552044 no 2268 0.337967844513022 738 6741907 YDL195W SEC31
SGTC_392 N-ethylmaleimide 8.33 µM -0.420052769947584 0.329365160067506 no 2269 0.337223452169767 704 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2121 5257820 149.641 µM -0.420150340474561 0.329324805360323 no 2270 0.337187814818588 727 791256
SGTC_2700 st077718 96.8 µM -0.421108426790224 0.328928651076582 no 2271 0.336837954225423 709 904970
SGTC_2432 5630864 12.22 µM -0.421888721583493 0.328606152815963 no 2272 0.336553121320366 756 5714970
SGTC_1145 3546-0597 10.2 µM -0.422925262490209 0.328177944628665 no 2273 0.336174895285079 719 875334
SGTC_201 4262-0159 12.803 µM -0.423140647929231 0.328088994475887 no 2274 0.336096323537651 736 1341029
SGTC_2183 6420625 130.508 µM -0.423673935034821 0.327868798845787 no 2275 0.335901813352284 705 2897619
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.424878424009675 0.327371682481538 no 2276 0.335462651974935 709 2333 A French combination drug.
SGTC_3264 9137442 49.47 µM -0.42583487891885 0.326977152564119 no 2277 0.335114084808613 738 17015726
SGTC_1461 k072-0203 53.8 µM -0.426610303381268 0.326657438103365 no 2278 0.334831595933252 734 5418714
SGTC_455 paf C-16 10 µM -0.426963208775287 0.32651197416667 no 2279 0.334703062633813 733 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1100 amiodarone 5.07 µM -0.427444439040647 0.326313658560492 no 2280 0.334527822752959 713 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2145 5634607 200 µM -0.429507411654432 0.325464061827671 no 2281 0.333777000644541 746 308662
SGTC_2775 cyproheptadine 69.59 µM -0.432897030918989 0.324070079357766 no 2282 0.332544788552406 738 2913 A selective serotonin reuptake inhibitor.
SGTC_2512 diallyl trisulfide 49.23 µM -0.433662772234955 0.323755508268681 no 2283 0.332266672045501 748 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2539 epi(13)torulosol 80 µM -0.434257350508079 0.32351133876886 no 2284 0.332050785469863 753 6708597
SGTC_471 1-acyl-paf 4 µM -0.436535075560505 0.32257667197854 no 2285 0.331224278128039 716 16759367
SGTC_162 k030-0015 37.8 µM -0.436808726875749 0.322464454138875 no 2286 0.331125034768245 740 1809920 YMR134W ERG29
SGTC_2823 7987624 58.44 µM -0.437537547312816 0.322165661281951 no 2287 0.330860776038371 791 2239440
SGTC_3337 9144342 33.5465 µM -0.438461221480055 0.321787149766209 no 2288 0.330525987506521 694 17682949
SGTC_254 nsc-64875 3.808 µM -0.438876081324025 0.321617204903107 no 2289 0.33037566438722 743 56993
SGTC_3157 9099274 49.47 µM -0.439415273421413 0.321396383851552 no 2290 0.330180330781115 735 17217662
SGTC_2416 tofa 880 nM -0.439786795045326 0.32124426738392 no 2291 0.330045766232805 733 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1039 k821-0043 94 µM -0.440016425737551 0.321150261980953 no 2292 0.329962605349553 750 15992768
SGTC_544 k015-0020 52.4 µM -0.440412093150209 0.320988311937563 no 2293 0.32981933388907 734 3008304
SGTC_1804 st050076 49.1 µM -0.441538807220946 0.320527324882345 no 2294 0.329411486717847 735 3895976
SGTC_1957 st077035 62.4 µM -0.441786865052432 0.320425870927013 no 2295 0.329321722148677 753 705593
SGTC_1482 3346-2049 8.48 µM -0.442234505192212 0.320242823132707 no 2296 0.329159759719868 736 3826804
SGTC_2089 5281248 129.67 µM -0.442290816135551 0.320219799710147 no 2297 0.329139387906905 717 2737878
SGTC_1286 0929-0070 131 µM -0.442376950754563 0.320184583849636 no 2298 0.329108227656905 738 1420408
SGTC_3281 9140613 49.47 µM -0.443140135768308 0.319872628907415 no 2299 0.328832188047618 706 16013766
SGTC_2407 paclitaxel 400 µM -0.443741561716352 0.319626883339566 no 2300 0.32861472151249 790 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_822 1487-0950 154 µM -0.44379132848756 0.319606551940211 no 2301 0.328596729198713 729 1958375
SGTC_809 3998-0021 90 µM -0.44408546562556 0.319486398102588 no 2302 0.328490397129254 760 715485
SGTC_3077 9117319 49.47 µM -0.444763766094047 0.319209387341273 no 2303 0.328245241019463 757 17154678
SGTC_1887 st057648 70.8 µM -0.445226066116859 0.319020646696565 no 2304 0.328078195674495 743 688672
SGTC_642 0335-0876 158 µM -0.445927850582613 0.318734222748301 no 2305 0.327824681847607 739 6812350
SGTC_1352 1496-0991 99 µM -0.44624544101125 0.318604638029109 no 2306 0.32770998100067 766 3000039
SGTC_385 1494-0393 12.4 µM -0.447714233403201 0.318005623269828 no 2307 0.327179724025681 745 3090647
SGTC_2050 5263056 171 µM -0.448901894636109 0.317521609502772 no 2308 0.326751214631385 737 763468 YGL055W OLE1
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.448982170411085 0.317488905538459 no 2309 0.326722259284341 735 390807
SGTC_2978 9011784 42.97 µM -0.449402564104995 0.31731766243916 no 2310 0.326570640979812 718 2994934
SGTC_3351 9150312 21.596 µM -0.449471896330703 0.317289424416413 no 2311 0.326545638516057 742 4904905
SGTC_305 1682-2595 20.8 µM -0.449826242873671 0.317145120754525 no 2312 0.326417866865725 747 226033
SGTC_756 0508-1999 28.3 µM -0.451865397355773 0.316315238777755 no 2313 0.325682976825149 730 6753853
SGTC_122 0236-0016 402.397 µM -0.453019488161826 0.31584596360156 no 2314 0.325267354293412 761 6808838
SGTC_2467 5474540 200 µM -0.454682643552539 0.315170215038113 no 2315 0.324668784641844 716 5413519
SGTC_766 1391-0721 126 µM -0.455507405788017 0.31483533898392 no 2316 0.324372120444946 766 1020919 YIL115C NUP159
SGTC_224 benfluorex 43.875 µM -0.456043128204551 0.314617902526741 no 2317 0.324179482584101 754 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2857 9024691 58.44 µM -0.459614800516172 0.313169894865905 no 2318 0.322896366850389 789 16478292
SGTC_2683 piperine 63.03 µM -0.45993899516919 0.313038603718385 no 2319 0.322780004599019 757 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.460336049649081 0.312877838361413 no 2320 0.322637514617505 769 61125 An anti-inflammatory.
SGTC_3168 9103419 49.47 µM -0.460504324829724 0.312809715322258 no 2321 0.322577133966208 750 16649256
SGTC_2406 ethylparaben 405.7 µM -0.461174117418336 0.312538625779609 no 2322 0.322336844776896 748 8434 A possible steroid mimic.
SGTC_3293 9120939 62.045 µM -0.461539710966142 0.312390699477036 no 2323 0.322205718795324 771 934087
SGTC_1452 4194-0072 190 µM -0.461804638734501 0.312283523406755 no 2324 0.32211071203194 756 1343545
SGTC_1575 cyproterone acetate 48 µM -0.462168031750705 0.312136539224128 no 2325 0.321980413174769 775 9880 An androgen receptor antagonist and liver toxin.
SGTC_2677 mitomycin C 100 µM -0.46220523294236 0.312121493877778 no 2326 0.321967075482667 748 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_965 1291-5240 308 µM -0.463389855229562 0.31164255888666 no 2327 0.321542474486574 768 2834598
SGTC_3154 9100113 49.47 µM -0.464001459485685 0.311395415907726 no 2328 0.321323349987707 752 25237525
SGTC_644 1498-1197 63.3 µM -0.464695447955628 0.311115085228476 no 2329 0.321074784323162 746 6741615
SGTC_490 phenamil 164 µM -0.465264764267299 0.310885196575743 no 2330 0.320870932291765 740 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_98 0074-0023 107.663 µM -0.465888744697159 0.310633319432516 no 2331 0.320647568989848 765 3563821
SGTC_1667 st014849 34.6 µM -0.465893969042403 0.310631210937689 no 2332 0.320645699129839 749 5348460
SGTC_952 1185-0122 232 µM -0.466911157635176 0.31022080211439 no 2333 0.320281721075092 742 678600
SGTC_2152 5568786 200 µM -0.467037684788964 0.31016976824926 no 2334 0.320236458259352 750 5399883
SGTC_2031 5180455 200 µM -0.471443892046798 0.308394840672204 no 2335 0.31866188913282 754 29949
SGTC_1449 4112-4002 201 µM -0.47187400783962 0.308221818343329 no 2336 0.318508360844875 723 2059539
SGTC_581 0958-0271 211 µM -0.473520368308704 0.307559932146127 no 2337 0.317920986455664 744 4591145
SGTC_691 1548-0686 185 µM -0.473738036496469 0.30747246982727 no 2338 0.317843362896129 762 46495133
SGTC_2291 7917025 104.35 µM -0.475488618874109 0.306769458084616 no 2339 0.317219371698916 737 2964612
SGTC_1109 tnp00067 928.257 nM -0.476166652045519 0.306497359184953 no 2340 0.316977827688371 760 676295
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.476333477554924 0.30643042741939 no 2341 0.316918409355312 719 6708561
SGTC_1289 0976-0073 69.1 µM -0.477708759945633 0.305878899026906 no 2342 0.316428754289386 771 3391136
SGTC_2005 4024620 188 µM -0.478938324022437 0.305386180322946 no 2343 0.315991252984122 756 236743
SGTC_3269 9137823 49.47 µM -0.479075235106627 0.305331338231718 no 2344 0.315942553452454 734 17682936
SGTC_2338 7999974 200 µM -0.479455413375899 0.305179074196515 no 2345 0.315807340074372 770 315925
SGTC_2448 5185112 27.17 µM -0.480733399644006 0.304667479075686 no 2346 0.315352995000065 723 5718189
SGTC_6 0844-0013 19.835 µM -0.481262025753748 0.304455974484422 no 2347 0.315165141302933 773 1584900
SGTC_2273 7815444 169.05 µM -0.481432333382314 0.304387847908579 no 2348 0.315104630597798 814 2824616
SGTC_1976 st070609 63.5 µM -0.481576847969176 0.304330044406178 no 2349 0.315053288112632 745 682556
SGTC_2943 9068529 45.32 µM -0.481646725724567 0.304302096184938 no 2350 0.315028463542996 757 3270634
SGTC_1632 st005650 90 µM -0.482794222233572 0.303843308485321 no 2351 0.314620926826035 735 2759605
SGTC_460 trequinsin 123 µM -0.4844308373191 0.303189497701175 no 2352 0.314040068862812 748 5537 A vasodilator.
SGTC_788 1182-0090 188 µM -0.485403298359659 0.302801307791521 no 2353 0.313695146564672 730 5715185
SGTC_1679 SEC14.276 6.7 µM -0.485517035496672 0.302755920402339 no 2354 0.313654815756414 735 1005053 YMR079W SEC14
SGTC_3197 9113331 49.47 µM -0.485612940163051 0.302717651520326 no 2355 0.313620810013238 743 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1384 3089-0840 101 µM -0.48641894637106 0.302396116170507 no 2356 0.313335080060865 745 1069836
SGTC_1183 1254-0324 198 µM -0.487348162882753 0.302025619458365 no 2357 0.31300581094031 734 5799357
SGTC_70 0141-0289 43.283 µM -0.489424985066736 0.301198287984127 no 2358 0.312270425466875 738 352408
SGTC_542 3381-0244 89.3 µM -0.489470746492508 0.301180069773696 no 2359 0.312254230129827 780 1112843
SGTC_2445 5742597 35.57 µM -0.49095313041339 0.300590182450257 no 2360 0.311729798873985 731 1774255
SGTC_3054 9094397 49.47 µM -0.491938999934415 0.300198162918042 no 2361 0.311381233488339 769 2598354
SGTC_393 acivicin 6.25 µM -0.492052558059251 0.300153022702851 no 2362 0.311341094571355 760 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1425 4048-4433 7.33 µM -0.492544355788406 0.299957564820548 no 2363 0.311167286772193 790 23734946
SGTC_2874 9043904 71.43 µM -0.493597352358921 0.299539260408964 no 2364 0.310795285507673 756 4463428
SGTC_1007 4101-0031 70 µM -0.494204321500352 0.299298261225895 no 2365 0.310580944039552 772 1146276
SGTC_1070 indatraline 8.81 µM -0.494598494264382 0.299141800699469 no 2366 0.310441782642916 772 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2511 berberine 10.47 µM -0.495055503889418 0.298960444581364 no 2367 0.310280470859906 767 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_140 0062-0056 502.533 µM -0.495141603508573 0.298926283074259 no 2368 0.310250084155255 750 3758964
SGTC_3145 9085516 49.47 µM -0.496274878930553 0.298476801897167 no 2369 0.309850243774801 743 25236195
SGTC_258 haloperidol 50.781 µM -0.497174177818245 0.298120339781477 no 2370 0.309533114575718 762 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1905 st060207 84.5 µM -0.498169683486772 0.29772596976738 no 2371 0.309182224297092 731 1948547
SGTC_2062 5245942 200 µM -0.498745641095943 0.29749791264413 no 2372 0.308979293402845 750 1376160
SGTC_730 1436-0052 41.2 µM -0.499686548117113 0.297125521243024 no 2373 0.308647902911993 728 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2587 piperic acid 92.2 µM -0.500586290968246 0.296769621236487 no 2374 0.308331156268018 762 5370536
SGTC_1929 genistein trimethyl ether 50.5 µM -0.500606543813634 0.296761612318558 no 2375 0.308324028070664 759 136420
SGTC_597 k018-0003 82.8 µM -0.501541016745912 0.296392185879938 no 2376 0.307995209337975 786 6786234
SGTC_123 0083-0120 66.675 µM -0.503812189009237 0.295495200332338 no 2377 0.307196680713056 757 16001701
SGTC_1852 st056254 31.4 µM -0.504587554149088 0.295189260730889 no 2378 0.306924276576581 754 442583
SGTC_1328 1441-0025 69.2 µM -0.505293573817939 0.294910810025362 no 2379 0.306676327829103 760 4562601
SGTC_1721 st082152 9.2685 µM -0.507576300572029 0.294011343208945 no 2380 0.305875257227742 745 5296051
SGTC_1850 st056238 17 µM -0.508096934004758 0.293806374861483 no 2381 0.30569268266481 777 5393177
SGTC_2007 4011539 71.82 µM -0.508189447265241 0.293769960203899 no 2382 0.305660245374183 775 45595301
SGTC_1381 2324-0066 62.1 µM -0.508873246748357 0.293500870882589 no 2383 0.305420536752792 780 10885928
SGTC_194 1486-1323 56.904 µM -0.508955067452782 0.293468680381829 no 2384 0.305391859765092 764 5178754
SGTC_2459 5811157 9.22 µM -0.509869637311118 0.29310897496447 no 2385 0.305071397406628 765 2870684 YBR192W RIM2
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.512843335449191 0.291940818600615 no 2386 0.304030456721589 759 4174840
SGTC_1186 1319-0216 26 µM -0.512946435614406 0.291900356728876 no 2387 0.303994395002915 763 4565136
SGTC_365 0121-0052 13.6 µM -0.513008361066223 0.291876055213615 no 2388 0.303972736029768 736 3101739
SGTC_1412 3909-8563 178 µM -0.51301281433161 0.291874307647076 no 2389 0.303971178487426 771 23767530
SGTC_2630 antimycin a 100 µM -0.513092426857742 0.291843066633519 no 2390 0.303943334378515 782 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1143 3454-2408 5.08 µM -0.513793860573869 0.291567882066262 no 2391 0.303698060384866 765 X1143
SGTC_2679 rapamycin 1 nM -0.514594938628428 0.29125375337856 no 2392 0.303418051342854 768 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1153 4055-0057 267 µM -0.515029238231262 0.291083516485346 no 2393 0.303266294375407 759 882706
SGTC_1401 3807-4679 7.6 µM -0.515763940588627 0.290795633488499 no 2394 0.303009645196605 773 3291456
SGTC_584 0986-0246 15.4 µM -0.516489950087501 0.290511287500643 no 2395 0.302756128157185 793 53315 YDR232W HEM1
SGTC_1766 st045414 44.774 µM -0.518260421689782 0.289818417780181 no 2396 0.30213829153216 778 253960
SGTC_733 4069-0007 56.1 µM -0.518419430416525 0.289756228062121 no 2397 0.302082830402303 764 5717425 YNL287W SEC21
SGTC_1863 st057641 20.1 µM -0.519465339290234 0.289347319995082 no 2398 0.301718138696114 784 3921635
SGTC_1029 k015-0030 64.7 µM -0.519629574221338 0.289283135419316 no 2399 0.301660890588016 745 2208316
SGTC_3226 9131256 49.47 µM -0.520107501464289 0.289096394978627 no 2400 0.301494325138721 753 17178073
SGTC_886 0866-0150 153 µM -0.520734886098883 0.288851343165032 no 2401 0.301275734194153 761 271463
SGTC_1348 1493-0373 93.8 µM -0.521343675585197 0.2886136479855 no 2402 0.30106369035827 795 3010129
SGTC_2521 angolensin 13.4 µM -0.521887542390706 0.288401379111018 no 2403 0.300874316260857 761 821428 A flavenoid.
SGTC_1072 oxiconazole 14.9 nM -0.523094623558032 0.287930523641956 no 2404 0.300454203386868 750 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1835 st008666 49.2 µM -0.524474472702915 0.287392720268923 no 2405 0.299974285154734 760 690455
SGTC_1616 st002734 56.1 µM -0.524869015249743 0.28723903266434 no 2406 0.299837125141084 759 4026101
SGTC_199 4063-0024 41.6 µM -0.525155713146164 0.287127378589292 no 2407 0.29973747439749 768 306215
SGTC_2304 7443016 91.4 µM -0.526033367907731 0.286785705027507 no 2408 0.299432511555606 782 939854
SGTC_2137 5261020 140 µM -0.526193108579427 0.286723538254196 no 2409 0.299377020846974 761 763655
SGTC_821 1114-0266 29.2 µM -0.528841681937134 0.285693717079091 no 2410 0.298457640071653 764 3123235
SGTC_1252 0493-0875 34.8 µM -0.52994553388162 0.285265036307105 no 2411 0.298074847312547 747 3960963
SGTC_2227 7312221 64.1025 µM -0.530018901062565 0.28523655503579 no 2412 0.298049413039406 780 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_504 lovastatin 124 µM -0.530402622245038 0.285087615863335 no 2413 0.297916404153402 799 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_765 1319-0117 244 µM -0.53069145286752 0.284975532378176 no 2414 0.297816304940849 748 3487746 YGL099W LSG1
SGTC_2482 5981709 142.65 µM -0.530730769288992 0.284960276890008 no 2415 0.297802680345979 780 877755
SGTC_396 dithiazanine 1.25 µM -0.530850446478327 0.284913842356514 no 2416 0.297761209521277 762 10578 An antihelmenthic.
SGTC_2723 salbutamol 83.58 µM -0.530854108209609 0.284912421668291 no 2417 0.297759940690967 782 9884233 β2-adrenoceptor agonist
SGTC_1990 st072050 59.8 µM -0.5317345451164 0.284570925543652 no 2418 0.297454931203646 765 17233948
SGTC_2878 9043973 25.97 µM -0.531962529536404 0.284482528823322 no 2419 0.29737597389376 770 6465167
SGTC_1074 carmofur 3.8 µM -0.53202006858303 0.284460221200849 no 2420 0.297356048043742 789 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_946 3434-1334 87.4 µM -0.53256094306905 0.284250567520642 no 2421 0.297168772296476 753 4047976
SGTC_1657 st012939 43.4 µM -0.537341418550055 0.282400779439646 no 2422 0.295515900233905 780 24207257
SGTC_2382 9035899 200 µM -0.537561936025754 0.282315590879425 no 2423 0.295439757377968 800 6462679
SGTC_2611 pyromycin 23.93 µM -0.537935565342421 0.282171281596591 no 2424 0.295310766875517 767 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_463 ikarugamyin 104 µM -0.538274859112437 0.282040264726545 no 2425 0.295193652718044 787 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2673 kobusone 100 µM -0.538335139872156 0.282016990628465 no 2426 0.295172847822799 783 6710676 An epoxy ketone and protein crosslinker.
SGTC_1053 3366-3204 134 µM -0.539271596350826 0.281655548342324 no 2427 0.294849732287206 776 3632071 YPR165W RHO1
SGTC_1081 sertraline 6 µM -0.539783046821337 0.281458239152833 no 2428 0.29467332995889 780 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2639 lactacystin 53 µM -0.540600956784487 0.281142841599997 no 2429 0.294391329130441 756 3870 A proteasome inhibitor.
SGTC_3277 9138724 49.47 µM -0.540736554307119 0.281090569794242 no 2430 0.294344589556184 777 15943418
SGTC_2112 5488546 200 µM -0.540738595555966 0.281089782944327 no 2431 0.294343885977313 792 600757
SGTC_31 0508-1974 57.237 µM -0.542495422177212 0.280412965465904 no 2432 0.293738630110951 751 6810525
SGTC_837 0091-0265 12.5 µM -0.543436077016807 0.280050902789062 no 2433 0.293414795861615 777 759367
SGTC_1681 tripelennamine 100 µM -0.543620266567072 0.279980033863207 no 2434 0.293351405272048 741 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_383 2324-0395 7.37 µM -0.544817653818073 0.279519538251183 no 2435 0.292939467846683 772 3146421
SGTC_1913 st060213 96.1 µM -0.544968562568605 0.279461527312428 no 2436 0.292887569726503 789 688959
SGTC_3038 9091290 49.47 µM -0.545564399044106 0.279232538529519 no 2437 0.292682700890843 793 25236843
SGTC_3205 9113483 49.47 µM -0.545841968952166 0.279125895447123 no 2438 0.292587285651769 788 17018033
SGTC_2463 5473429 200 µM -0.546407887901094 0.278908529272709 no 2439 0.292392794609489 762 5399405
SGTC_457 grayanotoxin iii 135 µM -0.549624271251327 0.277674701670197 no 2440 0.291288553965621 792 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_196 k015-0023 18.111 µM -0.550787981435543 0.277228951875271 no 2441 0.290889511974852 768 5211998
SGTC_3244 9134489 49.47 µM -0.550800251161034 0.277224253921293 no 2442 0.290885305986644 801 16584271
SGTC_1014 4130-3005 69.3 µM -0.55117317333405 0.277081484369939 no 2443 0.290757484068506 780 743608
SGTC_205 1486-1330 71.903 µM -0.551453163719635 0.276974316486013 no 2444 0.290661532494668 789 4118834
SGTC_711 k292-0785 179 µM -0.551496480076538 0.276957738721161 no 2445 0.290646689477231 778 4146315
SGTC_1335 1486-0900 202 µM -0.552169980380496 0.276700043417423 no 2446 0.290415949844495 764 X1335
SGTC_2033 5192550 145 µM -0.554056513288915 0.27597884253094 no 2447 0.289770085030658 761 182073
SGTC_3222 9128301 49.47 µM -0.555291543854996 0.275507204405733 no 2448 0.28934763093886 774 4911358
SGTC_340 k038-0059 454 µM -0.555602436985595 0.275388541855589 no 2449 0.289241332563038 779 23733424
SGTC_1848 st056003 16.4 µM -0.557029634538897 0.27484412806721 no 2450 0.288753590995989 769 146492
SGTC_1230 0170-0365 3.77 µM -0.558303006809868 0.274358840149628 no 2451 0.288318746037888 780 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1427 4048-4900 550 nM -0.558824481284558 0.274160226028847 no 2452 0.288140756449173 791 24132586
SGTC_960 1222-0186 7.7 µM -0.558941013466043 0.27411585209698 no 2453 0.288100988790948 796 3126296
SGTC_426 0988-0037 14.6 µM -0.559407981112052 0.273938072524491 no 2454 0.287941657858385 790 5383008
SGTC_2991 9074669 71.4286 µM -0.560193836557001 0.27363901768196 no 2455 0.287673615295778 805 17333109
SGTC_1491 4138-0063 26.5 µM -0.561189139189707 0.273260490356827 no 2456 0.28733430303366 780 23883227
SGTC_78 0336-0123 156.75 µM -0.56269872838146 0.272686868252114 no 2457 0.286820025152692 781 6765896
SGTC_1170 0310-0127 64.8 µM -0.564204239318958 0.27211539159066 no 2458 0.286307571523173 806 774975
SGTC_2356 9061756 188.97 µM -0.56650570411393 0.271242931302812 no 2459 0.285525028219376 762 20104043
SGTC_3334 9142812 21.919 µM -0.567027054510586 0.271045486928567 no 2460 0.285347900374938 773 45283678
SGTC_3258 9138477 49.47 µM -0.570889022135083 0.269585129441479 no 2461 0.284037436440806 791 4970355
SGTC_3079 9117512 49.47 µM -0.572066603121414 0.26914062671112 no 2462 0.283638426797834 818 7185044
SGTC_472 calcifediol 10 µM -0.572550457791972 0.268958092230492 no 2463 0.283474556126482 773 5283731 A vitamin D metabolite.
SGTC_2732 terfenadine 20 µM -0.575771173767754 0.267744660946868 no 2464 0.282384930098859 804 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1269 0831-0796 3.05 µM -0.576764507814789 0.267370971532449 no 2465 0.282049274330292 801 927758
SGTC_48 0382-0018 55 µM -0.57689600420671 0.267321522694917 no 2466 0.282004855019281 767 762596
SGTC_2517 totarol 10 µM -0.577086685586376 0.267249825711655 no 2467 0.281940449081814 779 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_909 3448-9333 149 µM -0.578019591664241 0.266899189125065 no 2468 0.281625446083376 790 3344074
SGTC_1065 prochlorperazine maleate 2.48 µM -0.578974862151144 0.266540387771424 no 2469 0.281303067540693 822 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2283 7944793 200 µM -0.580652990997695 0.265910670705852 no 2470 0.280737175135078 780 2970533
SGTC_1008 4106-0037 6 µM -0.58115464908499 0.265722570208519 no 2471 0.280568114806948 814 2905394
SGTC_149 3970-0822 46.1 µM -0.581285739419231 0.265673428014924 no 2472 0.280523945078879 784 3114250 YBL034C STU1
SGTC_1199 1638-0010 4.46 µM -0.581319014476403 0.265660954836231 no 2473 0.280512733878387 783 3111136
SGTC_2681 menadione 3.18 µM -0.58205741822461 0.26538424010035 no 2474 0.280264002970585 802 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1875 nocodazole 6 µM -0.583184628727599 0.26496210339567 no 2475 0.279884508858557 791 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2657 nystatin 74.44 µM -0.58370057884671 0.264768995633765 no 2476 0.279710888873666 781 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1280 0880-0253 10.1 µM -0.584104199732874 0.264617979912103 no 2477 0.279575104722788 806 6836607
SGTC_664 1222-0054 14.9 µM -0.585036431148716 0.264269350837258 no 2478 0.279261610384497 780 6813991
SGTC_424 splitomicin 100 mM -0.590321890053601 0.262297165654465 no 2479 0.27748743320602 802 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1818 st052136 56.3 µM -0.590529623424025 0.262219807491724 no 2480 0.277417815734533 785 674169
SGTC_2691 st077356 60.2 µM -0.591149728656146 0.261988955054042 no 2481 0.277210051304942 795 2839272
SGTC_1866 st057638 64 µM -0.592811640100717 0.261370773796376 no 2482 0.276653608428106 782 688802
SGTC_2387 9077560 195.08 µM -0.593754828223995 0.261020269617335 no 2483 0.276338052888901 777 5303272
SGTC_1367 1812-0510 76.9 µM -0.593803645912021 0.261002134743593 no 2484 0.27632172511983 779 1142582 YDR527W RBA50
SGTC_3186 9110464 49.47 µM -0.594633805022319 0.260693845102282 no 2485 0.276044139095441 792 17018021
SGTC_3072 9116419 49.47 µM -0.595207366515047 0.260480955613789 no 2486 0.275852433399832 786 17170162
SGTC_3223 9129970 49.47 µM -0.595712993357161 0.260293355784658 no 2487 0.275683488271458 795 17248386
SGTC_1108 betulinic acid 729.144 nM -0.596542508069307 0.259985736550806 no 2488 0.275406432688554 774 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_579 4491-1009 110 µM -0.596781552931996 0.259897123389833 no 2489 0.275326617811186 822 1271041
SGTC_1192 1488-0095 21.4 µM -0.597251784789864 0.259722855432607 no 2490 0.275169644955435 812 915875
SGTC_2191 5911152 200 µM -0.598016674883022 0.259439516001168 no 2491 0.274914403426487 788 2875902
SGTC_2210 7115885 190.385 µM -0.598408405983921 0.259294468285552 no 2492 0.274783729125121 809 2927039
SGTC_2900 5328528 85.29 µM -0.599889744472811 0.258746346728664 no 2493 0.274289858819522 798 795359
SGTC_1726 st035556 14.5795 µM -0.601135251741953 0.258285951438679 no 2494 0.27387495282876 775 5919439
SGTC_1051 3253-3903 78 µM -0.601878397865234 0.258011453708125 no 2495 0.27362754232542 806 5509239
SGTC_2082 5219693 150 µM -0.601993298303289 0.257969026157925 no 2496 0.27358929918988 796 2834649
SGTC_2516 gossypol 71.55 µM -0.60222967048863 0.257881755951674 no 2497 0.273510634061254 798 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_539 4859-0462 2.54 µM -0.603606458963056 0.257373740995191 no 2498 0.273052658788185 790 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_308 4092-1169 104 µM -0.605768798289719 0.256576920212956 no 2499 0.272334145848013 810 2268590 YDL196W YDL196W
SGTC_2258 7960471 200 µM -0.606247961970999 0.256400522742506 no 2500 0.272175054168627 823 2974708
SGTC_156 3474-0145 5.642 µM -0.607856584593964 0.255808793138033 no 2501 0.271641298200709 788 2265471
SGTC_1614 st002383 48.6 µM -0.60805910739403 0.255734345960248 no 2502 0.271574136203651 782 1947235
SGTC_2143 5623677 140.463 µM -0.609391506688716 0.255244839480338 no 2503 0.271132483096946 786 5375313
SGTC_3169 9102970 49.47 µM -0.610931429521546 0.254679702373388 no 2504 0.27062248832132 808 17027839
SGTC_3247 9135149 49.47 µM -0.610965807926227 0.254667093305959 no 2505 0.270611108281183 804 8934436 YOR116C RPO31
SGTC_24 0417-1663 219 µM -0.6116074852393 0.254431803465091 no 2506 0.270398742255189 825 4329390
SGTC_1574 spiramycin 23.7 µM -0.612410983844009 0.254137337808866 no 2507 0.270132938241375 811 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1670 st016595 4.04 µM -0.613148708779884 0.253867134323154 no 2508 0.269889007845419 824 597879
SGTC_1305 1181-0477 144 µM -0.613252040240437 0.253829299576428 no 2509 0.269854849873339 805 6252086
SGTC_2945 9067681 61.76 µM -0.613688861479513 0.25366939047613 no 2510 0.269710475099859 832 16456930
SGTC_3039 9090270 49.47 µM -0.615238624833454 0.253102488795231 no 2511 0.269198571624765 789 17173750
SGTC_1886 st057356 49.9 µM -0.615558937751019 0.25298540185327 no 2512 0.269092829640143 782 24207747
SGTC_1052 3253-3998 198 µM -0.615766065130557 0.252909703844335 no 2513 0.269024463664282 787 5450317
SGTC_770 0389-1121 67.2 µM -0.616209406718138 0.252747717655392 no 2514 0.268878160407716 794 6753108
SGTC_678 1218-2179 85.9 µM -0.617036200110482 0.252445773543706 no 2515 0.268605424366836 821 6820081 YOR116C RPO31
SGTC_941 3237-0776 460 µM -0.618043959934913 0.252077997899366 no 2516 0.268273180673335 805 760008
SGTC_133 0724-0033 378.92 µM -0.618761436422387 0.251816331702099 no 2517 0.2680367652131 795 280309
SGTC_1265 0819-1001 68.8 µM -0.620375287099848 0.251228279133175 no 2518 0.267505369349158 806 3106768
SGTC_209 4077-0173 175.592 µM -0.620397895980104 0.251220046103256 no 2519 0.267497928652614 786 15993494
SGTC_1571 st070080 73.4 µM -0.621280924659639 0.250898602610351 no 2520 0.267207401122494 805 4315245
SGTC_967 1306-0166 352 µM -0.621350212768255 0.250873389301285 no 2521 0.267184611204445 813 4437607
SGTC_1511 0906-3109 28.5 µM -0.623245040982719 0.250184398820329 no 2522 0.266561753761966 795 2882180
SGTC_1885 st057546 99.9 µM -0.623700950518867 0.25001877257545 no 2523 0.266411999368164 792 702008
SGTC_408 cantharidin 100 µM -0.623806085110651 0.24998058674711 no 2524 0.266377471436951 797 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_978 1416-0512 87.4 µM -0.624774664543995 0.249628935640269 no 2525 0.266059480556912 820 6814003
SGTC_2332 7982454 138.89 µM -0.627115875821699 0.248780025067641 no 2526 0.265291640615561 833 2981748
SGTC_2688 kanamycin b 96.69 µM -0.627443210610915 0.248661457836092 no 2527 0.265184375324805 806 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1625 st003711 30.1 µM -0.629307705834995 0.247986674586303 no 2528 0.264573813743338 806 24207034 YER133W GLC7
SGTC_142 0335-0849 62.6745 µM -0.630202769679447 0.247663087674085 no 2529 0.264280963703894 801 3889043 YPR107C YTH1
SGTC_861 0443-0273 110 µM -0.630819446113655 0.247440275721612 no 2530 0.26407929348225 814 6149169
SGTC_3239 9133757 49.47 µM -0.631230450430997 0.247291834870513 no 2531 0.263944927278159 833 17036923
SGTC_176 1486-1328 72.834 µM -0.632294914059617 0.246907608056544 no 2532 0.263597093154055 806 22310231
SGTC_1413 3910-0535 34.4 µM -0.632594263025594 0.24679961319788 no 2533 0.263499317228291 804 2876951
SGTC_1782 st039423 80.636 µM -0.633207048463398 0.246578620080553 no 2534 0.26329922174038 816 2068169
SGTC_2449 5812982 45.77 µM -0.635079670076971 0.245903940835141 no 2535 0.262688227739964 811 776185
SGTC_2572 astragaloside iv 100 µM -0.635836377238437 0.24563159119848 no 2536 0.262441537282912 805 45006101 An anti-inflammatory agent.
SGTC_1880 MG-132 525 µM -0.636617256831151 0.245350711494926 no 2537 0.262187090900001 810 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2122 5258151 111.688 µM -0.637588814988819 0.245001486515815 no 2538 0.261870689254982 811 2173356
SGTC_1314 1222-0010 41.1 µM -0.641730421078076 0.243515797515231 no 2539 0.260524116737738 826 3526027
SGTC_1137 ixabepilone 100 µM -0.644803332707225 0.242416626412388 no 2540 0.259527320968956 810 154225 A novel microtubule stabilizer.
SGTC_280 3448-3607 3.04 µM -0.645715529499324 0.242090854551543 no 2541 0.259231800729288 799 626179
SGTC_2226 7298446 200 µM -0.64782174253124 0.241339572650824 no 2542 0.258550125482064 825 3283010
SGTC_1287 0971-0001 34.6 µM -0.648638133434321 0.241048708705387 no 2543 0.258286150663969 809 4665869
SGTC_660 4031-1742 102 µM -0.649374462230841 0.240786532883872 no 2544 0.258048183280559 805 6738706
SGTC_1686 st019653 115.5 µM -0.649971865731504 0.240573936601806 no 2545 0.257855197480032 841 97252
SGTC_3164 9100705 49.47 µM -0.650033442341226 0.240552029320335 no 2546 0.2578353099714 790 17174235
SGTC_2695 st077686 51.995 µM -0.650758576551805 0.240294128037338 no 2547 0.257601171961977 806 2876092
SGTC_1242 0402-0103 60.1 µM -0.6515368036608 0.240017511416898 no 2548 0.25735001371901 823 432868
SGTC_225 nsc-122657 1.016 µM -0.65275287935968 0.239585611737423 no 2549 0.256957802979084 820 275685
SGTC_1996 st072960 66.8 µM -0.653776929741034 0.239222240793428 no 2550 0.256627765926433 806 1719405
SGTC_3204 9114183 49.47 µM -0.654023673182488 0.239134732137396 no 2551 0.256548276996848 801 17027248
SGTC_2641 levomentholum 100 µM -0.654166084393606 0.239084233333484 no 2552 0.256502404757048 816 16666
SGTC_1822 st052468 42 µM -0.654497493465844 0.238966738738016 no 2553 0.256395670741965 814 2873678
SGTC_1408 3909-7976 48.8 µM -0.655487164924616 0.238616058093732 no 2554 0.25607707373724 824 24152374
SGTC_1808 st050063 61.5 µM -0.65718166841133 0.238016281440811 no 2555 0.255532055632318 836 4011993
SGTC_753 1322-0200 289 µM -0.657612080799255 0.237864066877996 no 2556 0.255393714870801 810 5403907
SGTC_1629 st005085 44.9 µM -0.658813215326548 0.23743957030197 no 2557 0.255007860000059 831 24207091
SGTC_165 k038-0023 64.381 µM -0.659483428891184 0.237202888998029 no 2558 0.25479269189304 817 46368543
SGTC_2904 7225135 42.03 µM -0.660813087615756 0.236733713026194 no 2559 0.254366094304185 857 4446116
SGTC_2305 7443522 69.23 µM -0.661246875437433 0.236580759563431 no 2560 0.254227002153429 811 5415886
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.661549037107815 0.236474249581602 no 2561 0.254130138917677 840 364106
SGTC_3280 9140961 49.47 µM -0.662507197239133 0.236136679094473 no 2562 0.253823111900657 843 4901226
SGTC_3171 9103192 49.47 µM -0.662861203138793 0.236012026060756 no 2563 0.253709725680564 828 13018434
SGTC_3294 9122953 26.2835 µM -0.663575666745053 0.235760558648326 no 2564 0.253480967796646 822 16459826
SGTC_1569 carminic acid 40.6 µM -0.664135547237328 0.235563602642779 no 2565 0.253301780307992 815 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_706 4262-0057 46.9 µM -0.664351303115769 0.235487727796981 no 2566 0.253232746291352 830 883298
SGTC_627 1391-0720 175 µM -0.664553366309877 0.235416680486518 no 2567 0.253168102407039 846 997839
SGTC_3138 9097216 49.47 µM -0.665239670210193 0.235175457959947 no 2568 0.252948605465456 830 25237486
SGTC_1114 scopoletin 1.73284 µM -0.666269385379178 0.234813789202911 no 2569 0.252619465066405 818 5280460 A coumarin with genotoxic properties.
SGTC_2385 9074692 200 µM -0.666950306657038 0.23457479694131 no 2570 0.252401937885093 812 17046906
SGTC_1950 st077106 7.18 µM -0.668716192579956 0.2339556271318 no 2571 0.251838268122364 804 13831864
SGTC_3276 9139060 49.47 µM -0.669427408253315 0.2337065106914 no 2572 0.251611436352693 847 4870619
SGTC_483 fpl-64176 144 µM -0.669516024613566 0.233675481478306 no 2573 0.25158318103235 833 3423
SGTC_956 1185-0240 191 µM -0.670706697798742 0.233258786232259 no 2574 0.251203697598229 824 1416193
SGTC_926 2268-1401 59.4 µM -0.671967565498481 0.232817975228311 no 2575 0.250802172488286 831 2931578
SGTC_2719 novobiocin 32.65 µM -0.672179885677113 0.232743791690817 no 2576 0.250734592268644 841 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_582 0987-0078 156 µM -0.673972306146498 0.232118053355682 no 2577 0.250164460286825 837 1625765
SGTC_3268 9137683 49.47 µM -0.674041211707703 0.232094016962742 no 2578 0.250142556581837 876 1953228
SGTC_1166 k206-0078 225 µM -0.674452383596062 0.231950616284103 no 2579 0.250011874379721 814 5404595
SGTC_2461 5755302 26.15 µM -0.674763971212163 0.231841979575532 no 2580 0.249912867044716 853 2788904
SGTC_2733 amorolfine 100 µM -0.675070712877743 0.231735060123574 no 2581 0.249815419847088 850 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2614 arthonioic acid 13.39 µM -0.675955112833118 0.2314269429775 no 2582 0.249534572295835 826 6710684
SGTC_2566 crystal violet carbinol 226 nM -0.676655331415273 0.231183155118459 no 2583 0.249312331907695 856 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3220 9131269 49.47 µM -0.678223020081533 0.230637869041813 no 2584 0.24881514942879 836 17722206
SGTC_1939 st074455 53.6 µM -0.678958143986693 0.230382420039835 no 2585 0.248582191487197 836 1644229
SGTC_2760 etidronate 98.04 µM -0.679009410544752 0.230364611270475 no 2586 0.248565949647149 830 3305 A chelator and antioxidant.
SGTC_690 glyoxal 20.3 µM -0.679176088346233 0.230306716730274 no 2587 0.248513148094242 826 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_610 4215-0184 155 µM -0.682164038713154 0.229270251341282 no 2588 0.247567615524353 815 5605015
SGTC_1789 tunicamycin 25 nM -0.682500802275913 0.229153598430324 no 2589 0.247461167823985 843 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3053 9095903 49.47 µM -0.683384429663944 0.228847673434394 no 2590 0.247181978087964 865 17174018
SGTC_3143 9086658 49.47 µM -0.684221799831205 0.228557975051058 no 2591 0.246917559256486 838 25236626
SGTC_2296 7971656 126.45 µM -0.686893728064257 0.227634967645537 no 2592 0.246074849786246 820 666570
SGTC_752 1896-0090 130 µM -0.687700142939731 0.227356807525332 no 2593 0.245820814988245 830 772567
SGTC_1743 st037606 46.3785 µM -0.687820505461239 0.227315306798196 no 2594 0.245782910765044 811 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3304 9125678 46.087 µM -0.688247237337483 0.227168205003409 no 2595 0.245648550861048 832 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2909 7941780 10.49 µM -0.689815157823489 0.226628176938406 no 2596 0.245155217612344 822 1243215
SGTC_2824 7998404 51.95 µM -0.690053568513655 0.226546126297356 no 2597 0.24508025034909 852 837851
SGTC_1392 3455-1037 33.9 µM -0.690677314223372 0.226331539373331 no 2598 0.244884174414452 811 981132
SGTC_1144 3486-0183 12.5 µM -0.690777850834112 0.226296962560727 no 2599 0.244852578395912 857 6744069
SGTC_2979 9012552 45.46 µM -0.690909031788174 0.226251850953086 no 2600 0.244811354963812 844 17100905
SGTC_1515 3460-0031 42.1 µM -0.692223818048199 0.225799991959873 no 2601 0.244398391649917 832 2876596
SGTC_3301 9125354 19.7965 µM -0.692894001576085 0.22556986326197 no 2602 0.244188037164716 810 41905162
SGTC_1947 st076332 61.6 µM -0.694156116647188 0.225136836719427 no 2603 0.243792154783889 846 24208416
SGTC_2115 tiliquinol 12.7705 µM -0.694510362908962 0.225015380965735 no 2604 0.243681102128005 839 71208 A bioactive hydroxyquinoline.
SGTC_3022 9087993 49.47 µM -0.69648618309383 0.224338639016844 no 2605 0.243062203598012 835 17173644
SGTC_93 0109-0045 59.227 µM -0.698134268712125 0.223775034948029 no 2606 0.242546614413135 843 88733
SGTC_1685 st024049 53.0905 µM -0.698233165255448 0.223741240421328 no 2607 0.242515694342689 835 1941139
SGTC_2805 7950783 58.44 µM -0.699537943272357 0.223295648700658 no 2608 0.242107954583883 833 1178958 YDL195W SEC31
SGTC_2011 4012611 177 µM -0.704372981026892 0.221648856593311 no 2609 0.240600263835202 830 2049887
SGTC_2172 5754775 163.918 µM -0.705956314595814 0.221111092543862 no 2610 0.240107652458234 833 2263357
SGTC_981 1488-1094 54.9 µM -0.705971889853968 0.22110580626763 no 2611 0.240102809370643 840 3449522
SGTC_3111 9122088 49.47 µM -0.706505202354424 0.2209248424906 no 2612 0.239937009315381 830 16876704
SGTC_1827 berberine 7.24 µM -0.706563514143656 0.220905061257961 no 2613 0.239918884711301 815 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3322 9139058 2.11 µM -0.707103783055189 0.220721832907623 no 2614 0.239750992603565 828 4908926 YPR165W RHO1
SGTC_3237 9133362 49.47 µM -0.707800225363842 0.220485767933994 no 2615 0.23953466320336 842 43845137
SGTC_552 k242-0005 476 µM -0.710289893354879 0.219643058119564 no 2616 0.238762192924624 859 4088318
SGTC_1750 st081859 2.357 µM -0.710361449549547 0.219618864952814 no 2617 0.238740011321275 849 5291695
SGTC_3321 9137793 26.8275 µM -0.710934303651699 0.219425238016311 no 2618 0.238562473738395 843 4904192
SGTC_2224 6650123 117.647 µM -0.711481525261655 0.219240366593811 no 2619 0.238392947626193 842 2908370
SGTC_1945 st075991 56.6 µM -0.711752801318948 0.219148752848674 no 2620 0.238308932325301 836 1084980
SGTC_3286 9117135 37.221 µM -0.71256665174843 0.218874036200208 no 2621 0.238056976867609 835 3438150
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.712593768889439 0.218864886173403 no 2622 0.238048584335916 830 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3083 9117465 49.47 µM -0.713246333401283 0.218644760359785 no 2623 0.237846669912447 853 16420915
SGTC_1393 3470-5649 58.2 µM -0.713791977504304 0.218460799261064 no 2624 0.237677910584432 820 4108395
SGTC_311 1315-0136 58 µM -0.713915562981615 0.218419145438206 no 2625 0.237639696624027 836 6759207
SGTC_1962 st076595 64.5 µM -0.714184940469125 0.218328369052832 no 2626 0.237556413887801 837 279619
SGTC_2622 2-methoxyxanthone 59.94 µM -0.714776558064357 0.218129078631209 no 2627 0.23737356125169 837 71034 A hepatoprotective.
SGTC_1624 st003710 6.25 µM -0.716820594171115 0.217441338564822 no 2628 0.236742401377371 851 24207033
SGTC_2409 alverine citrate 63.97 µM -0.717373807559686 0.217255418870647 no 2629 0.236571738341082 826 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.717922923114488 0.217070967175396 no 2630 0.236402406427543 876 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2671 danthron 100 µM -0.719750256127194 0.216457805430046 no 2631 0.235839388657372 838 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2037 5169046 200 µM -0.720178913615872 0.216314114643293 no 2632 0.235707422544795 834 5718022
SGTC_2826 7992541 19.48 µM -0.720551926597596 0.216189121460723 no 2633 0.23559262024493 894 2985066
SGTC_86 0417-1630 471.922 µM -0.721679817185499 0.215811430326418 no 2634 0.235245676786793 839 3634867
SGTC_1455 4262-0120 131 µM -0.722065169987178 0.21568247684575 no 2635 0.235127205479583 848 1529587
SGTC_2822 7994718 71.43 µM -0.723201757935651 0.215302392240209 no 2636 0.234777969481786 879 1018011
SGTC_1123 mangostin 811.285 nM -0.723768744815694 0.21511293243985 no 2637 0.23460386037205 794 5281650 An antioxidant.
SGTC_1548 st061468 90.8 µM -0.724950337669541 0.214718412002292 no 2638 0.234241248967496 842 390799
SGTC_1495 4469-0029 237 µM -0.727577803075933 0.213842639671922 no 2639 0.233436036226045 832 793680
SGTC_2061 5245884 80.95 µM -0.728478631795764 0.213542859878936 no 2640 0.233160322239527 855 573863
SGTC_1933 st074711 15.9 µM -0.728633470228475 0.21349135707467 no 2641 0.233112949511253 850 17250958
SGTC_2070 5230947 200 µM -0.729284418793348 0.213274915898035 no 2642 0.232913850644978 869 2835538
SGTC_2342 7990637 118.86 µM -0.729571413572676 0.21317953044605 no 2643 0.232826100549726 860 2033102 YER133W GLC7
SGTC_2361 9034121 116 µM -0.729802687156632 0.21310268257145 no 2644 0.232755400857059 883 6496917
SGTC_2710 st078562 53.7235 µM -0.73006441829488 0.213015733717812 no 2645 0.232675404767199 857 17250908
SGTC_1838 st055369 84.5 µM -0.731479425953269 0.212546017188061 no 2646 0.23224318341378 835 676036
SGTC_3235 9132602 49.47 µM -0.733303935340558 0.211941259016804 no 2647 0.231686537677496 845 4912240
SGTC_1297 1068-0111 14.1 µM -0.733477054888868 0.211883928543857 no 2648 0.231633758695479 844 767057
SGTC_77 0828-0286 12.516 µM -0.734213934252651 0.211640004222246 no 2649 0.23140918115382 857 745345
SGTC_1006 4099-6547 255 µM -0.73545300764687 0.211230212703431 no 2650 0.23103182462555 868 3146833
SGTC_380 3970-0968 6 µM -0.735464998500897 0.211226249310804 no 2651 0.231028174521446 840 2891601
SGTC_2624 nerol 100 µM -0.736970381178991 0.210729014396191 no 2652 0.230570180744689 867 637566 A natural product oil.
SGTC_2802 7925815 54.55 µM -0.737154105327816 0.210668376502018 no 2653 0.230514319740767 849 1262923
SGTC_2318 6029776 164 µM -0.737827540931989 0.210446197587251 no 2654 0.230309627522087 856 818325
SGTC_1842 st055362 61.2 µM -0.738021104075329 0.210382362968114 no 2655 0.230250812394446 828 676032
SGTC_892 0929-0076 29 µM -0.738194162822938 0.210325300059535 no 2656 0.23019823474335 851 5751038
SGTC_1417 3966-0327 90.4 µM -0.739757334624085 0.209810285090696 no 2657 0.2297236258493 865 651118
SGTC_1325 1431-0015 227 µM -0.739905227854251 0.209761597433143 no 2658 0.229678751026429 838 1103340
SGTC_2676 harmalol 100 µM -0.74011544547955 0.209692403508992 no 2659 0.229614973739556 830 5459187 A monoamine oxidase inhibitor
SGTC_1583 clindamycin 39.6 µM -0.742095602768454 0.2090412862042 no 2660 0.229014706921227 865 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_3285 9112818 20.8695 µM -0.744390649738764 0.20828811828505 no 2661 0.228320087024442 857 17017947 YPR165W RHO1
SGTC_2087 5276107 200 µM -0.744473308754811 0.208261021892528 no 2662 0.228295091522504 847 144405
SGTC_2818 7996756 12.99 µM -0.746027848731468 0.207751816717826 no 2663 0.227825296181421 880 2241621
SGTC_2267 7931562 200 µM -0.746423956700465 0.207622185242197 no 2664 0.227705675979692 837 934880
SGTC_448 monastrol 171 µM -0.748673436497416 0.206886920652542 no 2665 0.22702702897711 859 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2749 bexarotene 57.39 µM -0.748848695765283 0.206829700223805 no 2666 0.226974202828478 866 82146 An retinoic acid receptor inhibitor.
SGTC_1644 st010134 20.9 µM -0.749606391903537 0.206582427702192 no 2667 0.22674590000238 854 3818134
SGTC_1682 st012968 530 nM -0.750239529798508 0.206375938845509 no 2668 0.226555227467829 844 24207270
SGTC_1073 triclabendazole 3.09 µM -0.751980501848441 0.205808776639906 no 2669 0.226031392247719 852 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_3267 9137951 49.47 µM -0.753136935791422 0.205432553054953 no 2670 0.225683815501868 893 16643986
SGTC_1747 st037496 66.6 µM -0.75475922091585 0.204905462643756 no 2671 0.225196732973261 874 723305
SGTC_672 1441-0018 53.7 µM -0.755753149354013 0.204582926800696 no 2672 0.224898605634418 842 251141
SGTC_755 1995-0008 37.3 µM -0.756444488441234 0.204358761290207 no 2673 0.224691371514289 831 689533
SGTC_186 3455-3465 67.277 µM -0.756816467271196 0.204238208322921 no 2674 0.224579912875639 849 755278
SGTC_1394 3474-0001 65.7 µM -0.759601208791851 0.203337059809551 no 2675 0.223746498185827 833 5017666 YIL048W NEO1
SGTC_634 1611-4317 11.2 µM -0.759868316756369 0.203250747960575 no 2676 0.22366665089476 867 2843522
SGTC_2142 5622915 118.518 µM -0.761651055654826 0.202675243389076 no 2677 0.223134147150718 861 5322196
SGTC_3141 9094609 49.47 µM -0.761740876511946 0.202646273171627 no 2678 0.223107336792741 884 25236309 YDL196W YDL196W
SGTC_1821 st053465 65.6 µM -0.762572637228295 0.202378120232781 no 2679 0.222859154186028 862 675086
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.765573120862283 0.201412553433934 no 2680 0.221965171512261 876 279621
SGTC_1214 0358-0031 63.7 µM -0.768321494918287 0.200530543750118 no 2681 0.22114810376444 898 4301366
SGTC_1768 st044301 37.178 µM -0.768698651631129 0.200409687663604 no 2682 0.221036112778765 896 3931349
SGTC_1555 citronellol 128 µM -0.768825446518825 0.200369067342363 no 2683 0.220998470244337 848 8842 A terpine precursor.
SGTC_1055 3448-0672 86 µM -0.769104535440019 0.200279675157461 no 2684 0.220915627983166 847 748378
SGTC_647 0140-0236 81 µM -0.770767112954787 0.199747648312524 no 2685 0.220422491868757 850 990837
SGTC_2369 9071472 200 µM -0.771385868049367 0.199549863212405 no 2686 0.220239124516385 871 17296037
SGTC_1958 st076513 41.9 µM -0.773019066073294 0.199028377811395 no 2687 0.219755548537349 881 732122 YGL099W LSG1
SGTC_401 neomycin 50 µM -0.773073806989233 0.199010913095073 no 2688 0.219739350784716 835 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_911 3456-4043 236 µM -0.773163025389481 0.198982450551397 no 2689 0.219712952666628 855 914281
SGTC_138 0850-0259 40.9225 µM -0.776971493473482 0.197769757785846 no 2690 0.218587794489384 856 6813004
SGTC_263 alizarin 107.927 µM -0.777053743713264 0.197743617018321 no 2691 0.218563531467288 887 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2595 hexamethylquercetagetin 100 µM -0.778279326218117 0.197354349838946 no 2692 0.218202180264478 891 386331
SGTC_3058 9093861 49.47 µM -0.779849502218883 0.196856311332366 no 2693 0.217739732439318 861 17217477
SGTC_2507 purpurin 79.67 µM -0.779965816501971 0.196819448320088 no 2694 0.217705498095259 870 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2626 ethyl orsellinate 100 µM -0.780517155235227 0.196644771651557 no 2695 0.21754326689906 879 75653 A natural product.
SGTC_562 3772-2733 112 µM -0.781118893827314 0.196454234376384 no 2696 0.217366285225894 855 2876874 YIL048W NEO1
SGTC_91 0417-1751 58.384 µM -0.781996436041065 0.19617656601553 no 2697 0.217108334050714 874 6795624
SGTC_2096 5468907 200 µM -0.782169462467392 0.196121845794185 no 2698 0.217057494280185 863 759785
SGTC_1812 st052057 4.327 µM -0.784177097210134 0.195487601230272 no 2699 0.216468100939382 874 3645418
SGTC_1807 st050092 58.9 µM -0.784498941835265 0.195386041242475 no 2700 0.216373701295648 874 5008496
SGTC_3191 9110352 49.47 µM -0.784641618306485 0.195341029088008 no 2701 0.216331860751198 859 17122424
SGTC_1364 1653-0028 37.6 µM -0.785055484636729 0.195210496497361 no 2702 0.21621051900813 846 5718652
SGTC_81 0411-0046 9.971 µM -0.785086840669207 0.195200609029707 no 2703 0.21620132731851 863 12925265
SGTC_1956 st077085 54 µM -0.785364939316901 0.195112929769921 no 2704 0.216119815541339 885 24208685
SGTC_2440 5628896 157.78 µM -0.785674945459343 0.195015218899439 no 2705 0.216028972537238 877 5522048
SGTC_2051 5263410 176 µM -0.786077232559612 0.194888466343277 no 2706 0.215911120859669 860 227584
SGTC_2161 5662504 8.5105 µM -0.788860783826724 0.194012798828967 no 2707 0.215096689256594 852 2859334
SGTC_574 1315-0397 40 µM -0.789130225672629 0.193928163521942 no 2708 0.215017948799207 878 6794277
SGTC_1919 st067113 52.3 µM -0.789840480623642 0.193705170743191 no 2709 0.214810467359397 881 1268243
SGTC_1155 4088-0394 48.2 µM -0.790412867906062 0.193525576931467 no 2710 0.214643344837008 873 2326248
SGTC_271 rotenone 740 µM -0.790853565713274 0.19338737159846 no 2711 0.214514723795511 877 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1936 st074407 74.3 µM -0.793766859386408 0.192475261880948 no 2712 0.213665584565979 879 809813
SGTC_510 ag-490 170 µM -0.793799859444263 0.192464945132232 no 2713 0.213655977251141 863 5328779
SGTC_2403 6032726 181.2 µM -0.795102406268392 0.192058002335421 no 2714 0.21327696752709 883 2881040
SGTC_1266 0828-0227 32.9 µM -0.795298996132963 0.191996629322948 no 2715 0.213219798684418 894 3913820
SGTC_2836 9010338 19.48 µM -0.795354956778833 0.19197916127117 no 2716 0.213203526817538 875 2994051
SGTC_3333 9141820 12.094 µM -0.795467024971475 0.191944182237189 no 2717 0.213170942546342 869 1939433
SGTC_3067 9117431 49.47 µM -0.795666653564955 0.191881883273018 no 2718 0.213112906937028 898 17150885
SGTC_2872 9044037 25.97 µM -0.796006662256268 0.191775803779503 no 2719 0.2130140815375 865 6465195
SGTC_3295 9122362 53.5725 µM -0.796055507477923 0.191760567483 no 2720 0.212999886601522 894 4730473
SGTC_661 1304-0007 33.6 µM -0.797228476939553 0.191394905614124 no 2721 0.212659175118646 863 3117130
SGTC_235 0330-0087 5 mM -0.797528686370057 0.191301386951792 no 2722 0.212572024706861 876 46494818 YHR062C RPP1
SGTC_405 ebelactone b 50 µM -0.799155150301912 0.190795211956946 no 2723 0.212100227103166 870 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2274 7947094 46.08 µM -0.799776162639504 0.190602162498909 no 2724 0.211920248181515 861 2971028
SGTC_298 1391-0729 10 µM -0.80235569634278 0.189801566366184 no 2725 0.211173616513283 874 3237558
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.80276714888718 0.18967405752846 no 2726 0.211054666572874 886 521171
SGTC_2020 4017018 200 µM -0.802934482445142 0.189622216058431 no 2727 0.211006302080121 892 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_431 k089-0097 107 µM -0.802971678301407 0.189610693625464 no 2728 0.210995552227912 855 5499420
SGTC_2902 5787006 60.46 µM -0.804456698326993 0.189151020030508 no 2729 0.210566633814462 868 591003
SGTC_845 0330-0138 4.51 µM -0.806978029070358 0.188372139763421 no 2730 0.209839570726196 871 9039800
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.807250858670432 0.188287977024063 no 2731 0.209760984847125 876 16486 A toxic proline analog.
SGTC_1558 st069300 45.6 µM -0.807349663266247 0.188257503409584 no 2732 0.20973252942488 857 24208000
SGTC_1011 4112-3381 17.4 µM -0.807545530495279 0.188197102438083 no 2733 0.209676126970091 872 2877139
SGTC_2071 5230951 39.92 µM -0.809151947920754 0.187702171409544 no 2734 0.20921387535492 881 1799272
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.810521960060361 0.187280711821351 no 2735 0.208820124495156 903 4620898
SGTC_2256 7954252 200 µM -0.81071360557928 0.187221802209028 no 2736 0.208765079096145 906 2972920
SGTC_2846 9008642 19.48 µM -0.813136086971097 0.186478147650103 no 2737 0.208070019169102 895 2992898
SGTC_1268 0828-0275 2.46 µM -0.813223692328123 0.186451288834681 no 2738 0.208044909001457 883 745337
SGTC_261 5-fluorouridine 15.376 µM -0.814102132350375 0.186182101511293 no 2739 0.207793222210648 869 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_5 0352-0601 109.883 µM -0.81410490296795 0.18618125287025 no 2740 0.207792428670033 864 762456
SGTC_2787 5284540 71.43 µM -0.815123017361678 0.185869566422129 no 2741 0.207500948766436 878 736958
SGTC_806 3966-4455 5.86 µM -0.81567390779087 0.185701051334264 no 2742 0.20734333302298 876 714982
SGTC_10 0279-0212 42.575 µM -0.815871256950019 0.185640706115042 no 2743 0.207286886507872 865 39851 YBR002C RER2
SGTC_447 ml7 120 µM -0.818273535679663 0.184907115636583 no 2744 0.206600506945234 887 4216 Selective myosin light chain kinase inhibitor.
SGTC_132 0417-1715 25.805 µM -0.818487365821618 0.184841905164952 no 2745 0.206539476663934 881 6769098
SGTC_1274 0865-0114 173 µM -0.819116898516681 0.184650003426091 no 2746 0.206359860745291 857 870624
SGTC_1731 st035964 63 µM -0.819486501465967 0.184537394339437 no 2747 0.20625445015096 911 6739575
SGTC_2715 st079500 56.4 µM -0.820643133250685 0.184185272632541 no 2748 0.205924785567858 869 28246688
SGTC_992 3909-8734 162 µM -0.821923544625144 0.183795955881971 no 2749 0.205560205943877 883 4288319
SGTC_398 bronopol 33.3 µM -0.822290854685214 0.183684367741788 no 2750 0.2054556902038 861 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1722 st034304 3.6505 µM -0.822408018128942 0.183648782578335 no 2751 0.205422358730867 897 4036148 YLR033W RSC58
SGTC_2194 5927483 104.545 µM -0.822527709814591 0.183612433967147 no 2752 0.205388311322293 849 760979
SGTC_771 0250-0039 27.3 µM -0.822895361799686 0.183500811483531 no 2753 0.20528375027061 886 3005115
SGTC_2207 7258803 200 µM -0.822898145427705 0.183499966510133 no 2754 0.205282958721177 868 3666799
SGTC_1172 0370-0043 85 µM -0.822973245306385 0.183477170773304 no 2755 0.205261604085781 882 376585
SGTC_2351 9026858 72.31 µM -0.823285849984365 0.183382302051132 no 2756 0.20517272918942 916 1409300
SGTC_172 1112-0046 2.638 µM -0.824662833048889 0.182964781782769 no 2757 0.204781519078584 901 2802135 YIL048W NEO1
SGTC_3353 9151644 39.2805 µM -0.825321489020189 0.182765278100497 no 2758 0.204594547469969 881 4909158
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.826203130666247 0.182498445783603 no 2759 0.204344436315538 875 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_993 3909-8757 62.7 µM -0.828698527830229 0.181744523942762 no 2760 0.203637509513714 865 4288324 YLR208W SEC13
SGTC_2414 st077232 92.9 µM -0.829351699117849 0.181547506791841 no 2761 0.203452712214309 857 729801
SGTC_707 0865-0008 204 µM -0.83026424363445 0.18127247838481 no 2762 0.20319469980267 896 723043
SGTC_2704 st078022 71.1 µM -0.83104617883436 0.181037021526383 no 2763 0.202973771264735 887 54697681
SGTC_2608 thymoquinone 42.66 µM -0.831112337527917 0.18101710857187 no 2764 0.202955085324091 884 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_525 k781-2675 26.7 µM -0.831637963128972 0.180858950488615 no 2765 0.202806663509699 858 3651118 YDL195W SEC31
SGTC_219 mitoxanthrone 164.414 µM -0.835001729435986 0.179848862029099 no 2766 0.20185836732031 899 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1527 coumarin 137 µM -0.837128189763328 0.179212149651182 no 2767 0.201260258231572 917 323 A hepatotoxic, DNA x-linker.
SGTC_1787 fluconazole 80 µM -0.838635028852081 0.178761825847314 no 2768 0.200837073813719 847 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2136 5328288 199.296 µM -0.841954523248066 0.177772299938486 no 2769 0.199906704669673 885 262395
SGTC_2367 9070478 135.38 µM -0.84474295752121 0.176943756424476 no 2770 0.199127184666933 870 572802
SGTC_3240 9133527 49.47 µM -0.846626782162742 0.176385388269413 no 2771 0.19860159051103 894 17617455
SGTC_285 1486-1325 46 µM -0.84855636817791 0.175814613431042 no 2772 0.198064097131411 886 22310230
SGTC_1993 st073995 70.8 µM -0.850002306602226 0.175387670075423 no 2773 0.197661901922764 880 3098394
SGTC_2029 5175081 200 µM -0.852458550032003 0.174663921225198 no 2774 0.196979817677339 879 1380876
SGTC_1473 k844-0725 134 µM -0.853719662718981 0.17429306358676 no 2775 0.196630168384311 884 54682906
SGTC_592 k241-0073 46.5 µM -0.853771371857258 0.174277868074807 no 2776 0.19661583981663 882 4230158
SGTC_1709 st033179 39.1045 µM -0.854593486114409 0.174036390465685 no 2777 0.196388117487391 890 573381
SGTC_3273 9137859 49.47 µM -0.855028359199296 0.173908742318477 no 2778 0.196267724072526 933 2377234
SGTC_3331 9141060 1.957 µM -0.857847170393521 0.173082781858046 no 2779 0.195488429537002 887 4906567 YPR165W RHO1
SGTC_3350 9150499 3.57 µM -0.858019010959299 0.173032510536712 no 2780 0.19544098297932 896 4910996 YPR165W RHO1
SGTC_508 roscovitine 141 µM -0.858615765634179 0.172858004414082 no 2781 0.195276268558336 910 160355 A CDKinase inhibitor.
SGTC_688 0527-0193 473 µM -0.859225091520374 0.172679937919546 no 2782 0.195108171329862 922 4007154
SGTC_1124 fisetin 1.16336 µM -0.859678524506742 0.17254750474073 no 2783 0.194983138011562 893 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_977 1348-1378 135 µM -0.862095838421496 0.17184257858087 no 2784 0.194317390634889 873 X977
SGTC_3127 9126946 49.47 µM -0.864668047891046 0.171094505143161 no 2785 0.193610505820438 865 27243249
SGTC_583 1488-1091 88.9 µM -0.865276111748501 0.170917967301042 no 2786 0.193443629487187 920 4303273
SGTC_1220 1838-0075 193 µM -0.866653992774822 0.17051836156746 no 2787 0.19306581026953 874 5529645
SGTC_2975 9084847 53.72 µM -0.867679615694522 0.170221304560688 no 2788 0.192784874024871 886 27211724
SGTC_2855 9016525 58.44 µM -0.867756159618291 0.170199148012181 no 2789 0.192763917311477 893 43811474
SGTC_1476 4112-3294 3.34 µM -0.867973460179929 0.17013625785174 no 2790 0.19270443087822 864 704369
SGTC_2549 cedrol 20.94 µM -0.868486181713497 0.169987927300206 no 2791 0.192564116869375 882 6708665 A sedative which affects the nervous system.
SGTC_681 1642-0006 26.6 µM -0.868635917689585 0.169944624264761 no 2792 0.192523151137806 926 4446530
SGTC_2556 citropten 84.59 µM -0.87155296392432 0.169102437439526 no 2793 0.191726150058866 876 2775 A potential DNA crosslinker.
SGTC_891 0929-0073 133 µM -0.871648658151066 0.169074854829247 no 2794 0.1917000385688 905 5603632
SGTC_429 1112-0049 25.5 µM -0.872056417179441 0.168957356006286 no 2795 0.191588800304659 902 2836170
SGTC_949 1165-0505 146 µM -0.874993077064224 0.168112685123676 no 2796 0.190788836277496 896 6244267
SGTC_2300 7976697 71.57 µM -0.876919998851457 0.167559923983669 no 2797 0.190265046412784 881 2236109
SGTC_2404 5161160 200 µM -0.878665187596538 0.167060306737023 no 2798 0.189791419687775 897 2831543
SGTC_1992 st073643 23.3 µM -0.880461192008088 0.166547145879273 no 2799 0.189304759828025 911 3161292
SGTC_1903 st060211 78.3 µM -0.883578751856419 0.165658804099279 no 2800 0.188461826693532 880 688960
SGTC_226 1,3-diallylurea 8.28947 mM -0.885232712207231 0.165188758029389 no 2801 0.188015566312277 890 74537 YKL182W FAS1
SGTC_1622 st003707 19.4 µM -0.888208230424617 0.164345308466669 no 2802 0.18721437618255 882 10140899
SGTC_2833 9001315 45.46 µM -0.888723671454416 0.164199484194256 no 2803 0.18707580301188 887 2989378
SGTC_1443 4112-3303 14 µM -0.889587898679167 0.163955172601509 no 2804 0.186843603218121 888 704433
SGTC_640 3381-0960 37.1 µM -0.891175716351602 0.16350692162694 no 2805 0.186417454928748 909 1745025
SGTC_1490 4089-0339 670 nM -0.894001328991524 0.162711203577739 no 2806 0.185660590045665 883 742542
SGTC_680 0417-1641 114 µM -0.895015786364881 0.162426138738869 no 2807 0.185389324607172 904 2835990
SGTC_2954 9074818 52.69 µM -0.895942624880481 0.162165979310164 no 2808 0.185141703618628 906 16648742
SGTC_1262 0737-0114 49.6 µM -0.896899725223216 0.161897610450816 no 2809 0.184886213372049 916 765919
SGTC_2478 5763493 32.33 µM -0.896919625548826 0.161892033515085 no 2810 0.18488090346634 883 1365576 YLR208W SEC13
SGTC_260 nsc-65238 3.989 µM -0.897707963628093 0.16167120762769 no 2811 0.184670631352687 916 3246252
SGTC_2345 9052315 157.45 µM -0.898346435066373 0.161492505702387 no 2812 0.184500441944937 909 6469265
SGTC_1979 st071809 45.3 µM -0.899280230994398 0.161231377352938 no 2813 0.184251707291881 922 4976333
SGTC_1421 4029-0249 71.4 µM -0.899476623033988 0.16117649301195 no 2814 0.184199421035488 901 2894095
SGTC_616 4092-0450 108 µM -0.899774709496193 0.161093212119848 no 2815 0.184120077904086 927 787165
SGTC_2249 haloperidol 116.36 µM -0.900879936131105 0.160784673468413 no 2816 0.183826080039076 889 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.901220558773731 0.160689661979896 no 2817 0.183735531057577 908 641818 YHR062C RPP1
SGTC_3332 9141069 11.198 µM -0.904008162512303 0.159913480639209 no 2818 0.182995536600679 909 17332883
SGTC_1475 4092-1048 11.7 µM -0.906149926159855 0.159318795834518 no 2819 0.182428251331779 926 2881759
SGTC_2079 5212404 121 µM -0.907264791357527 0.159009814790435 no 2820 0.182133394147507 892 758462
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.907525164018406 0.158937710000111 no 2821 0.182064574274202 928 5393153
SGTC_361 000s-0510 1.45 µM -0.910079929832035 0.158231357490066 no 2822 0.181390179117398 903 660
SGTC_200 k038-0079 37.545 µM -0.910341022364928 0.158159285717288 no 2823 0.181321345325371 924 3436683
SGTC_68 0986-0284 82.829 µM -0.910622049643521 0.15808173525269 no 2824 0.181247274266016 877 423278 YIL048W NEO1
SGTC_1486 3970-0793 4.53 µM -0.912658111556875 0.157520622461805 no 2825 0.180711190512267 912 2844330
SGTC_3192 9110362 49.47 µM -0.91359524598345 0.157262800494556 no 2826 0.180464782676592 938 16649480
SGTC_2560 caryophyllene 100 µM -0.91814629467724 0.156014675386248 no 2827 0.179271140384431 917 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2174 5790901 200 µM -0.918212916680268 0.155996452920818 no 2828 0.17925370381885 920 786020
SGTC_1603 st002045 67.8 µM -0.918286801460816 0.155976245579426 no 2829 0.179234367658714 922 5887985
SGTC_278 4092-0821 23.9 µM -0.918405062901037 0.155943904900428 no 2830 0.179203420548977 913 877900
SGTC_996 3970-0799 1.8 µM -0.918910124146591 0.155805836736033 no 2831 0.179071292003471 914 6615648 YGL040C HEM2
SGTC_3254 9136651 49.47 µM -0.919851385169632 0.155548740145574 no 2832 0.178825213288286 930 16454030
SGTC_3070 9117005 49.47 µM -0.920294048456179 0.155427927644275 no 2833 0.178709559173353 930 8779016
SGTC_793 0488-0545 106 µM -0.920519587865887 0.155366396817377 no 2834 0.178650650871996 908 292548
SGTC_2359 9039622 200 µM -0.920701690487747 0.155316727984671 no 2835 0.178603096683243 915 6463596
SGTC_3209 9113616 49.47 µM -0.921113856356488 0.155204347674089 no 2836 0.178495493335026 912 16649353
SGTC_2793 7325131 81.82 µM -0.92117285190711 0.155188266459226 no 2837 0.178480094821889 893 4176441
SGTC_2940 9060638 45.86 µM -0.921959648837595 0.154973903738667 no 2838 0.178274811830861 891 4027022
SGTC_2255 7941087 197.44 µM -0.924544129415311 0.154271139108099 no 2839 0.177601543317354 927 935561
SGTC_3228 9131799 49.47 µM -0.925331671120042 0.154057412598162 no 2840 0.177396704639699 914 17015818
SGTC_1636 st007707 68.9 µM -0.925803995485632 0.153929325165364 no 2841 0.177273925206053 931 403051
SGTC_2294 7971431 200 µM -0.92637353261145 0.153774968808299 no 2842 0.177125946965985 942 5741572
SGTC_1327 1436-0082 2.18 µM -0.926524196606602 0.153734152888251 no 2843 0.17708681420954 926 15992205
SGTC_543 3844-1095 191 µM -0.926641840447483 0.153702287343568 no 2844 0.17705626175021 922 4230703
SGTC_3243 9134147 49.47 µM -0.92668326938962 0.153691066753432 no 2845 0.177045503322252 911 24282180
SGTC_1316 1272-0050 65.9 µM -0.92692220681918 0.153626363665042 no 2846 0.176983463186563 911 7340392
SGTC_2923 7992654 58.14 µM -0.92793354525169 0.153352697919744 no 2847 0.176721021177053 881 2985126
SGTC_2363 9053361 176 µM -0.929917339339398 0.152816826649413 no 2848 0.176206942304791 914 6469797 YMR079W SEC14
SGTC_2148 5546263 113.568 µM -0.930434913141081 0.152677221821678 no 2849 0.1760729744637 930 792097
SGTC_1650 st011916 45.8 µM -0.930936207365939 0.152542088748998 no 2850 0.17594328188597 930 242528
SGTC_484 loperamide 105 µM -0.931251441350015 0.152457152290402 no 2851 0.175861756962656 875 3955 An opioid-receptor agonist.
SGTC_1173 0443-0020 122 µM -0.931392137276586 0.152419253394966 no 2852 0.175825378302561 924 5331295
SGTC_1162 k048-0130 20.1 µM -0.931408368252626 0.152414881701509 no 2853 0.175821181891003 907 6797406
SGTC_1246 0422-0085 105 µM -0.932305410187038 0.152173399479365 no 2854 0.175589356273121 911 264295
SGTC_188 3229-0966 278.469 µM -0.932551660878921 0.152107153661498 no 2855 0.175525750765192 911 5722370
SGTC_1062 mesoridazine 14.2 µM -0.933831996260271 0.151763029346048 no 2856 0.175195280957136 888 4078 A neuroleptic.
SGTC_3121 9125696 49.47 µM -0.934264467162353 0.151646908226555 no 2857 0.175083744281988 948 1235365
SGTC_3003 9075612 71.4286 µM -0.935618345875375 0.151283765311529 no 2858 0.174734862680799 931 6501993
SGTC_853 0419-0306 21 µM -0.936733957916678 0.150984966287694 no 2859 0.174447712023613 905 762713
SGTC_1206 3978-0017 132 µM -0.937115805182948 0.150882784826152 no 2860 0.174349496130032 914 3873677
SGTC_3266 9136860 49.47 µM -0.938539735945008 0.150502150150187 no 2861 0.173983553174652 887 4871271 YPR165W RHO1
SGTC_2429 5902844 64.44 µM -0.938685314492249 0.150463271238223 no 2862 0.173946167764891 909 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2030 5175110 200 µM -0.940209119688659 0.150056718013431 no 2863 0.173555152412836 935 2831986
SGTC_1136 pergolide 1.05886 µM -0.94139336402896 0.149741266294037 no 2864 0.173251656502807 911 47811 A dopamine receptor agonist.
SGTC_850 0388-0143 75.9 µM -0.943531194501981 0.149172925074224 no 2865 0.172704633602013 912 67273
SGTC_173 1273-0061 2.693 µM -0.944480568072897 0.14892099708431 no 2866 0.172462063614069 892 2847414 YPL266W DIM1
SGTC_2156 5649887 115 µM -0.944955753731419 0.148795007521686 no 2867 0.172340732795615 923 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1884 5633444 25 µM -0.946736300507067 0.148323551407299 no 2868 0.171886584006892 912 5724239
SGTC_20 0481-0013 4.944 µM -0.94700401572647 0.14825275183967 no 2869 0.171818366330242 914 182045
SGTC_2464 5717415 7.67 µM -0.947848846300514 0.148029477476652 no 2870 0.171603204779273 905 5285744
SGTC_1344 1488-0097 29.1 µM -0.948369472026663 0.147891997081702 no 2871 0.171470697526148 919 747966
SGTC_1849 st056239 19.2 µM -0.948929747500752 0.14774414199426 no 2872 0.171328171873053 887 5393181
SGTC_2106 5357045 167.29 µM -0.949696479990762 0.147541963967988 no 2873 0.171133249432925 909 668842
SGTC_45 0kpi-0036 14.9 µM -0.951060368627132 0.147182781415231 no 2874 0.170786865748643 920 2795021
SGTC_412 gemfibrozil 100 µM -0.953218720175449 0.146615574340779 no 2875 0.170239631676949 896 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2881 9058953 51.95 µM -0.954763236578869 0.146210582581748 no 2876 0.16984872134748 889 17122249
SGTC_2444 5485484 36.41 µM -0.957924352844909 0.145384042322018 no 2877 0.169050452695553 953 6790631
SGTC_2885 9057732 51.95 µM -0.9606902587569 0.144663421114723 no 2878 0.168353965308765 904 6471414
SGTC_1563 conessine 56.1 µM -0.962856901313588 0.144100613556765 no 2879 0.167809670361734 928 441082 An anti-amoebic, histamine inhibitor.
SGTC_1596 piperlongumine 63 µM -0.963130488647791 0.144029651579248 no 2880 0.167741021542666 917 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2093 5331342 194.4 µM -0.968416576340123 0.142663193735404 no 2881 0.166418182077807 901 33839
SGTC_145 3737-0113 38.366 µM -0.971782862698902 0.141797588946744 no 2882 0.165579291606596 913 6849351
SGTC_2235 salicylic acid 500 µM -0.972263183793774 0.141674370055006 no 2883 0.165459817231347 931 338 A COX inhibitor and kinase inhibitor.
SGTC_2259 7964009 200 µM -0.973818222687477 0.141275946693672 no 2884 0.165073401740128 918 313134
SGTC_1564 D-Arginine 115 µM -0.973895967890075 0.141256047209321 no 2885 0.165054097987919 937 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_292 k038-0015 474 µM -0.976341569703117 0.140631046494509 no 2886 0.164447613191798 932 46368540
SGTC_406 estrone 100 µM -0.977274155333479 0.140393208947203 no 2887 0.164216722214098 908 5870 A steroid.
SGTC_2815 7968870 71.43 µM -0.977577254335082 0.140315968376076 no 2888 0.164141725788591 942 2977326 YHR190W ERG9
SGTC_1674 st016616 23.6 µM -0.977720605013628 0.140279447500586 no 2889 0.164106263966713 905 625830
SGTC_1932 st074806 40.9 µM -0.980695492174188 0.139523004482524 no 2890 0.163371463757221 923 17251235
SGTC_754 3474-0146 171 µM -0.98099750414137 0.139446365436886 no 2891 0.163296986174041 902 24762078
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.98170926842762 0.139265860263777 no 2892 0.163121548994132 908 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.982898996651623 0.138964497380793 no 2893 0.162828575852756 917 688803
SGTC_389 tpck 16.7 µM -0.983114271480807 0.138910014884796 no 2894 0.162775600543997 929 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1478 0453-0656 35.7 µM -0.983530592681536 0.138804692146149 no 2895 0.162673183100648 951 5258496
SGTC_3034 9090421 49.47 µM -0.986071119403089 0.138163157375706 no 2896 0.162049107319679 903 17173761
SGTC_602 3130-1533 38.1 µM -0.986322024147167 0.138099908686681 no 2897 0.16198755774213 945 720941
SGTC_2211 7117706 200 µM -0.987331801531839 0.13784556115681 no 2898 0.161740002696947 923 822771
SGTC_1741 st038134 10.228 µM -0.988812103777412 0.137473273590474 no 2899 0.161377540589117 943 1272587
SGTC_1921 5740136 50 µM -0.990522456432883 0.137043985140771 no 2900 0.160959409220918 924 1774243
SGTC_2755 lomerizine 42.69 µM -0.992659540901816 0.136508878009305 no 2901 0.160437949053516 911 3949 A calcium channel blocker.
SGTC_731 3966-0296 387 µM -0.993085683382694 0.136402346805411 no 2902 0.160334100127642 914 660956
SGTC_2293 7624732 200 µM -0.993364446695379 0.136332689644243 no 2903 0.160266190587196 908 894453
SGTC_2085 5307070 144.047 µM -0.995805948443712 0.135723649103469 no 2904 0.159672219759763 948 2840351
SGTC_2734 clemastine 41.6 µM -0.997103103406494 0.135400828790991 no 2905 0.159357233407978 970 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_772 k072-0172 35.3 µM -0.999474201385204 0.134812099496541 no 2906 0.158782515251348 898 5861980
SGTC_1711 st032263 62.8 µM -1.00004229994474 0.134671305258828 no 2907 0.15864501879966 937 3958979
SGTC_2586 curcumin 80 µM -1.00050172329028 0.134557518279967 no 2908 0.158533882038591 948 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2636 apigenin dimethyl ether 100 µM -1.00109997218272 0.1344094468388 no 2909 0.158389239250308 940 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1987 st072290 61.9 µM -1.00110778560928 0.134407513692934 no 2910 0.158387350716838 929 54697379
SGTC_1492 4158-0558 28.5 µM -1.0015590598052 0.13429589483319 no 2911 0.158278301175891 895 3967268
SGTC_2868 9035608 32.47 µM -1.00224290350562 0.134126873222996 no 2912 0.158113145575582 923 6462614
SGTC_2314 7727897 200 µM -1.00346851072667 0.133824312908657 no 2913 0.157817431397471 889 900724
SGTC_2330 7979373 200 µM -1.00368942254424 0.133769827309746 no 2914 0.157764168514873 915 1863007
SGTC_339 3091-4833 71.4 µM -1.00496574496616 0.133455334252596 no 2915 0.157456672344414 924 3240077
SGTC_2475 5812728 15.03 µM -1.00527729584541 0.133378643638664 no 2916 0.157381672240983 928 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1187 1391-0724 117 µM -1.00714219899986 0.132920217478805 no 2917 0.156933222397514 937 6997986
SGTC_1294 1000-1494 117 µM -1.00802292584283 0.132704096821943 no 2918 0.156721728174932 924 712797 YDL207W GLE1
SGTC_3110 9122132 49.47 µM -1.01583771644308 0.130797034329791 no 2919 0.154853336097453 928 918317
SGTC_1703 st026983 48.3 µM -1.01630432081546 0.130683770067404 no 2920 0.15474224583569 917 1104023
SGTC_3046 9092212 49.47 µM -1.01692143175996 0.130534075776608 no 2921 0.154595403506916 961 25236637
SGTC_675 1309-0189 238 µM -1.01846908706701 0.130159178516033 no 2922 0.15422754219059 927 4246530
SGTC_3088 9117578 49.47 µM -1.02158620493937 0.129406364744453 no 2923 0.153488394776474 967 678341
SGTC_1291 0993-0025 5.79 µM -1.02243230771517 0.129202544508977 no 2924 0.153288167952311 939 4353356
SGTC_2990 9074105 71.4286 µM -1.02322179848588 0.129012562507455 no 2925 0.153101494280613 936 6502001
SGTC_317 4495-0002 170 µM -1.02380207745778 0.128873048528257 no 2926 0.152964384476072 924 15991618
SGTC_573 3702-0553 84.7 µM -1.02554085781408 0.128455627764338 no 2927 0.152554028561861 930 1222756
SGTC_2842 9000675 19.48 µM -1.02930483884022 0.127555243991582 no 2928 0.151668225095444 909 2989072
SGTC_2674 ligustilide 100 µM -1.03030375182547 0.127317032088049 no 2929 0.151433719206822 934 5319022 A signalling regulator.
SGTC_2675 theaflavin digallate 100 µM -1.03523753556835 0.126145006604056 no 2930 0.150278996631858 952 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2264 7948757 110.76 µM -1.0358702239941 0.125995256633502 no 2931 0.150131345299545 932 2971411
SGTC_2558 carylophyllene oxide 100 µM -1.03674038070844 0.125789503227921 no 2932 0.149928433691445 949 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1898 st060199 18.6 µM -1.03697107292493 0.125734994093345 no 2933 0.149874669320709 914 688866
SGTC_2078 5212016 200 µM -1.03710141571194 0.125704203320409 no 2934 0.149844297744313 931 1899708
SGTC_2240 6690706 185.951 µM -1.03780610741408 0.125537825659799 no 2935 0.149680166443876 933 805876
SGTC_3175 9106517 49.47 µM -1.03787845578492 0.125520752917123 no 2936 0.149663322417079 947 41468073
SGTC_2655 perillic acid 100 µM -1.04006139795481 0.125006384876099 no 2937 0.14915568822534 946 5702197 An apoptosis inducer.
SGTC_1621 st003705 32.4 µM -1.04217857437332 0.124508921485568 no 2938 0.148664447309275 940 24207032
SGTC_1205 4161-2785 76 µM -1.04299057912481 0.124318496098598 no 2939 0.148476328004566 944 3498106
SGTC_2776 terbinafine 19.92 µM -1.04316695881127 0.124277159772342 no 2940 0.148435486706024 910 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2095 5432005 200 µM -1.04574687918506 0.123673628413268 no 2941 0.147838956321205 956 783734
SGTC_2232 chlorophetanol 41.5365 µM -1.04578432137002 0.123664884543885 no 2942 0.147830310754843 948 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1727 st034309 9.9045 µM -1.05297411810531 0.121993868064206 no 2943 0.146176427166532 965 870305
SGTC_856 0433-0016 11.3 µM -1.05500483980302 0.121524783359328 no 2944 0.145711555630908 943 3911780
SGTC_386 1509-0011 3.07 µM -1.05573760387 0.121355830883861 no 2945 0.145544056018325 938 3107280
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.05644237805735 0.121193487880606 no 2946 0.145383076702346 931 688664
SGTC_1669 st015249 58.4 µM -1.05700218504319 0.121064646610849 no 2947 0.145255295105194 962 722793
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.05790612619648 0.1208568052993 no 2948 0.145049120978377 958 115019
SGTC_740 k014-0057 261 µM -1.05905373592732 0.120593299728033 no 2949 0.14478765395902 950 4012779
SGTC_2236 dapsone 200 µM -1.05973649635382 0.12043672144011 no 2950 0.14463224711245 934 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2922 7999257 32.47 µM -1.06057637930256 0.120244306524709 no 2951 0.144441230926148 962 2988377
SGTC_1229 0139-0193 12.2 µM -1.06486140496193 0.119265990169468 no 2952 0.143469326314847 935 3090752
SGTC_2540 epiandrosterone 100 µM -1.06766201458355 0.118629625129988 no 2953 0.142836499437557 944 441302 A steroid.
SGTC_1911 st060208 74.3 µM -1.06866223226544 0.118402934386434 no 2954 0.142610947771854 958 688783
SGTC_2727 riluzole 51.77 µM -1.07062636467703 0.117958672076095 no 2955 0.142168732000553 954 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2968 9090663 33.37 µM -1.07447544239638 0.117091481322828 no 2956 0.141304822788668 931 25236811
SGTC_3275 9138069 49.47 µM -1.07695125448362 0.116536077758993 no 2957 0.140751021664767 958 17617007
SGTC_2281 7943571 200 µM -1.0778761553072 0.116329073168116 no 2958 0.14054451393566 959 1244024
SGTC_2450 5739737 12.93 µM -1.07889708327634 0.116100879550944 no 2959 0.140316804618709 934 2262825
SGTC_82 0054-0107 293.755 µM -1.08100351735112 0.115631062539255 no 2960 0.139847774513405 943 3104697
SGTC_684 1140-0066 328 µM -1.08113095959749 0.115602681333992 no 2961 0.139819431754713 943 6813534
SGTC_1319 1306-0155 43.7 µM -1.08211313841922 0.115384117550914 no 2962 0.139601129250162 948 3122360
SGTC_1774 st048371 48.465 µM -1.0822427578625 0.11535529534869 no 2963 0.139572336900672 960 4242727
SGTC_14 0354-0009 295 µM -1.08228504122386 0.115345894319971 no 2964 0.139562945376929 954 1713507
SGTC_982 1491-0518 27.5 µM -1.08572137510785 0.114583700013155 no 2965 0.13880114044662 949 3091256
SGTC_2813 7971799 71.43 µM -1.08626484034319 0.114463486019404 no 2966 0.138680918848105 961 2234054
SGTC_277 nystatin 15.5 µM -1.09148546376967 0.11331326102142 no 2967 0.137529662348389 975 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_782 0083-0095 30.5 µM -1.09159477447671 0.113289265768944 no 2968 0.137505626992664 957 3591729 An indicator and reagent.
SGTC_1981 st071826 47 µM -1.09235437135209 0.113122623572985 no 2969 0.137338685217001 925 11838600
SGTC_2768 sulfasalazine 50.2 µM -1.0924152428902 0.113109277001869 no 2970 0.137325313057529 972 5384001 An antioxidant and salicylic acid derivative.
SGTC_3122 9126309 49.47 µM -1.09346610845992 0.112879043449973 no 2971 0.137094600805657 977 17591206
SGTC_2231 micatex 6.853 µM -1.09427153361283 0.112702809907455 no 2972 0.136917953123687 972 20737 An antifungal of unknown mechanism.
SGTC_1631 benzylvanillin 81.9 µM -1.09535022667414 0.112467091040024 no 2973 0.136681615473491 922 75506
SGTC_357 1325-0123 420 µM -1.09595905691612 0.112334203436952 no 2974 0.136548346238817 978 1098503
SGTC_924 2046-0044 21.3 µM -1.09663708377826 0.112186344580901 no 2975 0.136400034908438 940 3623589
SGTC_951 1171-0579 82.7 µM -1.09677301958986 0.112156717497363 no 2976 0.136370313628587 938 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3172 9105863 49.47 µM -1.09877889978403 0.111720187772415 no 2977 0.135932258960601 983 2348785
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.10145261913376 0.1111402111496 no 2978 0.135349857511957 956 16623 A steroid.
SGTC_1437 4092-1038 11.6 µM -1.10181731727287 0.111061269127187 no 2979 0.135270550094441 959 3977136
SGTC_2168 5727979 200 µM -1.10219879518396 0.110978737959408 no 2980 0.135187627834723 959 695210
SGTC_1226 3909-7979 35.4 µM -1.10419142655906 0.110548354399398 no 2981 0.13475505396031 952 6615510
SGTC_805 3852-0218 479 µM -1.10571113669506 0.110220921062252 no 2982 0.134425784081011 952 6615355
SGTC_1216 1165-0504 9.65 µM -1.10717691266029 0.109905767818334 no 2983 0.134108723663474 970 6304004
SGTC_1684 st024538 14.6195 µM -1.10972391138092 0.109359682366213 no 2984 0.133559007904197 969 6732859
SGTC_1365 1672-3266 55.4 µM -1.11216963929788 0.108837146675214 no 2985 0.133032609562098 929 6415873
SGTC_1460 k062-0059 9.15 µM -1.11289141518359 0.108683281126463 no 2986 0.132877533756145 926 1373085
SGTC_1440 4100-1550 40 µM -1.11348730219137 0.108556370049082 no 2987 0.132749599403676 966 742806
SGTC_223 busulfan 5 mM -1.11449592239151 0.108341798701553 no 2988 0.132533246398218 943 2478 A DNA alkylator.
SGTC_2173 5763948 167 µM -1.11470895139567 0.10829651850707 no 2989 0.132487581929884 963 2867177
SGTC_1775 st081588 35.1725 µM -1.11590662670263 0.108042201191532 no 2990 0.132231052482689 938 1426443 YGL099W LSG1
SGTC_307 1501-1223 22.3 µM -1.11723201424095 0.107761266690264 no 2991 0.131947567786914 961 2830329
SGTC_1257 0669-0121 16 µM -1.11758667405852 0.107686180885031 no 2992 0.131871781397558 939 4307855
SGTC_2892 9047358 58.44 µM -1.11825143488291 0.107545544468827 no 2993 0.13172981118305 971 6466771
SGTC_159 3970-0959 50 µM -1.11889295563956 0.107409950251416 no 2994 0.131592904283011 930 6615653
SGTC_348 k064-0012 10.7 µM -1.11907796486697 0.107370868914738 no 2995 0.13155343972756 944 5066323
SGTC_2212 7123476 200 µM -1.11927864877096 0.107328488051423 no 2996 0.131510640824224 942 1085715
SGTC_1244 0416-0015 52.5 µM -1.11997365992275 0.107181807289984 no 2997 0.1313624933833 946 96201
SGTC_1159 4092-0538 61.2 µM -1.12126753711675 0.106909122160066 no 2998 0.13108699967578 980 717301
SGTC_1752 st044819 83.042 µM -1.12140979781931 0.106879171228084 no 2999 0.13105673374839 954 441209 YML126C ERG13
SGTC_2320 7373003 200 µM -1.12142781294537 0.106875378835917 no 3000 0.131052901379428 944 5415828
SGTC_2750 bromebric acid 70.15 µM -1.12378201697719 0.106380626688555 no 3001 0.130552756113575 970 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2117 5521686 200 µM -1.12737497993608 0.105628732478932 no 3002 0.129791986469753 973 803312
SGTC_1779 st039427 55 µM -1.12794667694777 0.105509449498695 no 3003 0.129671219701587 959 1124498
SGTC_1613 st002381 52.1 µM -1.13007729068495 0.105065761015045 no 3004 0.129221828920521 950 551167
SGTC_1922 5578187 25 µM -1.13486612738905 0.104073444523051 no 3005 0.12821570708471 899 1350412
SGTC_1249 0481-0015 10.2 µM -1.13578285019767 0.103884263706092 no 3006 0.128023728126115 948 4227577
SGTC_1638 st008370 60.6 µM -1.1361925995433 0.103799785897637 no 3007 0.127937983532664 925 24207134
SGTC_3318 9139014 38.6185 µM -1.13651340451142 0.103733680493768 no 3008 0.127870879391528 955 16643984
SGTC_1814 st052110 31.539 µM -1.14191155934848 0.102625908656782 no 3009 0.126745391652814 961 674163
SGTC_1983 st071813 46.9 µM -1.14542103642732 0.1019103456972 no 3010 0.12601739412717 970 11838595
SGTC_2100 5377183 190 µM -1.15009522973458 0.100962951895691 no 3011 0.125052325454785 937 2844202
SGTC_860 0443-0016 25.1 µM -1.15254302128971 0.100469387803816 no 3012 0.124549000912848 959 5337942
SGTC_849 0386-0493 241 µM -1.15317586478366 0.100342070353018 no 3013 0.124419103868358 973 726119
SGTC_2694 st077685 81.9 µM -1.15621730651923 0.099731826082252 no 3014 0.123796141302605 961 2838096
SGTC_3158 9100007 49.47 µM -1.15638398674229 0.0996984613867917 no 3015 0.123762064290699 979 19297233
SGTC_160 3453-0671 289.699 µM -1.15853427979698 0.0992687641750562 no 3016 0.123323035441783 997 5322268
SGTC_689 0833-0039 98 µM -1.16003480201165 0.098969715118026 no 3017 0.123017318500521 977 5374726
SGTC_1697 st025554 27.742 µM -1.16392873450811 0.0981967426967994 no 3018 0.12222644682519 964 1269519
SGTC_1892 st058411 7.36 µM -1.16459417852714 0.0980650911381666 no 3019 0.122091650677592 973 3934738
SGTC_2964 9083345 53.42 µM -1.1654952674132 0.0978870257525703 no 3020 0.121909287390396 942 17741579
SGTC_1940 st075990 51.1 µM -1.1666496939895 0.0976592444003792 no 3021 0.121675933066804 991 1084979
SGTC_2618 avocadyne 43.43 µM -1.16758176386449 0.0974756202815523 no 3022 0.121487754807269 975 3015189
SGTC_3147 9097027 49.47 µM -1.16862064431197 0.0972712523224353 no 3023 0.121278253455609 976 25236841
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.17484882250122 0.0960526375692808 no 3024 0.120027601735648 964 2374 Ca(2+)-ATPase inhibitor.
SGTC_2214 7179297 48.276 µM -1.17660889276693 0.095710302599058 no 3025 0.119675823363141 981 769744
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.17871672479062 0.0953015099560449 no 3026 0.11925549681105 966 1377
SGTC_532 1548-0774 215 µM -1.18182906272267 0.0947002561382765 no 3027 0.118636766778364 991 5932993
SGTC_2213 7173844 200 µM -1.18257632133338 0.0945563148499414 no 3028 0.11848855070002 977 892728
SGTC_3163 9099914 49.47 µM -1.18324753835417 0.0944271586967033 no 3029 0.118355528814033 999 16268368
SGTC_1534 6-azauridine 81.6 µM -1.18442081482218 0.0942017083403513 no 3030 0.118123262335941 974 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1366 1683-0113 21.9 µM -1.18488703122648 0.0941122330817129 no 3031 0.118031057836982 989 708623
SGTC_1342 1486-1464 234 µM -1.18533576858729 0.0940261715973566 no 3032 0.117942358294686 960 3253938
SGTC_2758 dehydroepiandrosterone 69.35 µM -1.18575942963291 0.0939449727031294 no 3033 0.117858658742289 980 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2944 9067346 25.62 µM -1.18664070715694 0.0937762328185586 no 3034 0.117684685977038 957 6473075
SGTC_1699 st031318 29.054 µM -1.19187160510693 0.092779266007297 no 3035 0.116655796757981 968 5340658
SGTC_1163 k060-0048 49.9 µM -1.19279372199729 0.092604333639965 no 3036 0.116475084706968 972 6809982
SGTC_792 4534-1957 155 µM -1.19404898094792 0.0923665940530606 no 3037 0.116229404332825 975 1717904
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.19408632368782 0.0923595284548583 no 3038 0.116222101216139 961 23665772 A membrane-active detergent.
SGTC_2006 4011487 200 µM -1.19443498724108 0.0922935773263093 no 3039 0.116153928826504 970 45595294
SGTC_2303 7774051 200 µM -1.19721313695157 0.0917693238898982 no 3040 0.115611745370077 971 2953184
SGTC_1870 st057514 26.5 µM -1.19848828718349 0.0915294354065408 no 3041 0.115363490080127 971 5393161
SGTC_2333 9017922 200 µM -1.20603457286137 0.0901192915868152 no 3042 0.113902080070563 959 3163164
SGTC_2347 9049783 174.81 µM -1.2072234811999 0.0898986048331371 no 3043 0.113673044919079 994 6467988 YPL169C MEX67
SGTC_2133 5320837 200 µM -1.20784010864305 0.0897843039211355 no 3044 0.113554385189975 996 2841355
SGTC_488 nitrendipine 139 µM -1.20935891033152 0.0895032326128223 no 3045 0.113262493717382 1012 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_3092 9117248 49.47 µM -1.21064779348931 0.0892652240463788 no 3046 0.11301520939032 1016 17141857
SGTC_2179 6298986 200 µM -1.21327042567197 0.0887823763854541 no 3047 0.112513223053507 930 738374
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.21433221418432 0.0885874466359991 no 3048 0.112310444460708 985 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_818 4072-2707 53.5 µM -1.21515308800267 0.0884369641505477 no 3049 0.112153854444045 963 882871
SGTC_3296 9122258 64.045 µM -1.2187357828766 0.0877824141850998 no 3050 0.111472245976254 973 4730474
SGTC_438 sphingosine 6.67 µM -1.22055837877303 0.0874508201785216 no 3051 0.111126636618306 989 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2864 9034755 47.6 µM -1.22106945022971 0.0873580064301326 no 3052 0.111029862693846 970 4930451
SGTC_299 1273-0059 1.44 µM -1.2211078489448 0.0873510359562657 no 3053 0.111022594144588 936 2848077
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.22543563326785 0.0865680761323375 no 3054 0.110205564021753 991 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_3041 9091929 49.47 µM -1.22692171856764 0.086300435004177 no 3055 0.109926007340727 972 25236887
SGTC_379 3970-0972 5.9 µM -1.23012457731254 0.085725711121928 no 3056 0.109325228927521 989 2898042 YBL034C STU1
SGTC_1520 flindersine 88 µM -1.23397960323214 0.0850377673172428 no 3057 0.108605252392987 964 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2798 7813637 45.45 µM -1.23516797823341 0.0848265339554267 no 3058 0.108383997060992 975 956368
SGTC_2730 imipramine 71.33 µM -1.23542750180962 0.0847804560876199 no 3059 0.108335721339874 963 3696 A tricyclic antidepressant.
SGTC_310 1273-0058 1.06 µM -1.2354468166005 0.084777027537448 no 3060 0.108332129084838 911 2734232
SGTC_1559 coumarin 343 70.1 µM -1.24153485339196 0.0837015192490925 no 3061 0.107204115517386 981 108770 A hepatotoxic, DNA x-linker.
SGTC_1258 0671-0043 57.1 µM -1.24301376008559 0.0834418107528594 no 3062 0.106931381462364 1001 4298767
SGTC_2040 5100729 123 µM -1.2433277711052 0.083386745799931 no 3063 0.106873537286479 994 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2131 toluylene red 5.2905 µM -1.24490377509884 0.0831107903367442 no 3064 0.106583561536276 945 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_536 3852-0578 10.6 µM -1.24935564519481 0.0823349862226708 no 3065 0.10576751188392 994 2869208
SGTC_2889 9059656 51.95 µM -1.24962904531735 0.0822875205487071 no 3066 0.105717543909899 995 3949838
SGTC_1847 st056231 15 µM -1.25416935332767 0.0815022762864683 no 3067 0.104890228275755 972 5393180
SGTC_1826 st055655 41.6 µM -1.25916724142386 0.0806444422168294 no 3068 0.10398496556813 997 676168
SGTC_2731 amoxapine 43.43 µM -1.25950005871814 0.0805875607747128 no 3069 0.103924884515848 1032 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1436 4092-1007 8.32 µM -1.26079236191031 0.0803669818991476 no 3070 0.103691833216618 956 2881121
SGTC_1409 3909-8004 61.9 µM -1.26140434563324 0.0802626837695747 no 3071 0.103581601724013 987 2119279
SGTC_2753 fluvastatin 17.09 µM -1.26381762474114 0.0798523943951786 no 3072 0.103147746849186 996 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_118 0083-0097 135.343 µM -1.26502065638991 0.07964845647968 no 3073 0.102931961611042 1010 5207356
SGTC_3216 9129716 49.47 µM -1.26521804584776 0.0796150326850318 no 3074 0.102896587624659 967 8056934
SGTC_1647 st011722 22.4 µM -1.2653228510495 0.0795972904200461 no 3075 0.102877809169344 975 2854783
SGTC_1772 st048439 82.2 µM -1.26801065732239 0.0791432985269735 no 3076 0.102397072361356 962 2927068 YDL195W SEC31
SGTC_3159 9100096 49.47 µM -1.26980107333135 0.0788419728347189 no 3077 0.102077749153755 995 25236875
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.2721248055386 0.0784521875269442 no 3078 0.101664389481694 988 616764
SGTC_723 4182-0001 115 µM -1.27356728793021 0.0782109599946943 no 3079 0.1014084057786 984 744821 YLR208W SEC13
SGTC_3309 9129340 25.759 µM -1.27362712883875 0.0782009649163791 no 3080 0.101397796530758 984 17158987
SGTC_1780 st038448 24.544 µM -1.27425537339321 0.0780960892586557 no 3081 0.101286463294767 995 728868 YDL195W SEC31
SGTC_2801 7907800 81.82 µM -1.27445784404293 0.0780623126766826 no 3082 0.101250601804644 974 6620925
SGTC_1104 tacrolimus 29.8 µM -1.27451096519156 0.0780534527298728 no 3083 0.10124119454827 958 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3198 9112019 49.47 µM -1.27489403396361 0.0779895842091285 no 3084 0.101173375522344 1017 45595555
SGTC_1865 st057639 52.2 µM -1.27776938403087 0.0775114463772832 no 3085 0.100665376219038 992 688818
SGTC_2883 9059145 45.46 µM -1.27807945862963 0.0774600177760201 no 3086 0.1006107054617 1006 16476510
SGTC_3256 9138902 49.47 µM -1.2831725526242 0.0766189876002169 no 3087 0.0997158148782001 1015 17228773
SGTC_815 1582-0027 36.9 µM -1.28652135850911 0.0760697905644055 no 3088 0.0991305848208777 990 3128206
SGTC_2728 chlorpromazine 9.18 µM -1.28784676021035 0.0758532571700884 no 3089 0.0988996556655124 1030 2726 A thorazine and dopamine antagonist.
SGTC_961 1252-1571 372 µM -1.29076051527255 0.0753788821243251 no 3090 0.0983933666446814 996 6813498
SGTC_346 4513-0042 7.16 µM -1.29161936974763 0.0752394883586508 no 3091 0.0982444963756406 961 2827372
SGTC_1694 st024011 44.9 µM -1.29175927189917 0.0752168005904881 no 3092 0.0982202619522343 997 2787533
SGTC_1633 st005664 67.9 µM -1.2921067674019 0.0751604702193316 no 3093 0.0981600863055913 1017 2063822
SGTC_1663 st014140 55.4 µM -1.29213606803694 0.0751557219434231 no 3094 0.0981550135621837 984 4207120
SGTC_572 0960-0087 17.7 µM -1.29404904144597 0.0748462122383396 no 3095 0.0978242408527972 997 6796365
SGTC_2485 5633444 17.78 µM -1.2950349474248 0.0746870776947136 no 3096 0.0976540870074599 981 5724239
SGTC_857 0438-0306 1.35 µM -1.29670895328636 0.0744174688998073 no 3097 0.0973656737876469 972 4686136
SGTC_3165 9101544 49.47 µM -1.30027067121956 0.0738463057662651 no 3098 0.096754108200141 997 5002184
SGTC_1222 0366-0074 1.18 µM -1.30389111112777 0.0732691655913355 no 3099 0.0961353557077032 997 286520
SGTC_2239 6685329 187.64 µM -1.30941292738047 0.0723955773205967 no 3100 0.0951972574159647 966 805680
SGTC_550 4123-0385 25.7 µM -1.31003578953646 0.0722975393506875 no 3101 0.0950918642529825 1004 5731123
SGTC_1313 1220-0047 237 µM -1.31363841500837 0.0717324840758152 no 3102 0.0944839573673571 992 3528706
SGTC_1439 4092-1168 46 µM -1.31384396505555 0.0717003469384492 no 3103 0.0944493594650323 1010 2886240
SGTC_3013 9080133 71.4286 µM -1.32110181187014 0.0705726701244036 no 3104 0.0932337095071361 1006 17050193
SGTC_1308 1187-1617 41.4 µM -1.3215154832531 0.0705088095545867 no 3105 0.0931647716761178 1002 2882570
SGTC_2028 5153890 36.43 µM -1.3234368215472 0.0702127848759238 no 3106 0.0928450767307009 1004 2830968 YPR165W RHO1
SGTC_2120 5538279 151.968 µM -1.32563499618427 0.069875280861018 no 3107 0.0924803142090336 1009 2058197
SGTC_677 0929-0063 136 µM -1.32619898383747 0.0697888887318098 no 3108 0.0923868979037828 1029 1539583
SGTC_2072 5231554 129 µM -1.32765586958607 0.0695661021644345 no 3109 0.0921459092810484 991 789545
SGTC_528 3492-0019 172 µM -1.33624019774341 0.068264492392876 no 3110 0.0907353880620788 979 2869262
SGTC_2427 5545055 42.75 µM -1.33727327309058 0.0681091264763656 no 3111 0.090566725908377 992 5372858
SGTC_3302 9125395 16.351 µM -1.33755890685129 0.0680662177467163 no 3112 0.090520133808144 993 17599668
SGTC_2565 isoliquiritigenin 100 µM -1.33917433541638 0.0678239360650487 no 3113 0.0902569626761976 970 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2269 7935389 174.42 µM -1.34084110418319 0.0675746531015728 no 3114 0.0899860237650675 978 97605
SGTC_1960 st011366 51.8 µM -1.34177193699303 0.0674357455833404 no 3115 0.0898349769859302 990 3972846
SGTC_638 3970-0837 4.09 µM -1.34363296135853 0.0671586880314767 no 3116 0.0895335526582929 986 4118451 YLR208W SEC13
SGTC_1285 0929-0069 65.5 µM -1.3469988789735 0.0666598280471275 no 3117 0.0889902968638247 1001 1206237
SGTC_1298 1079-1278 263 µM -1.34704440051413 0.0666531010444363 no 3118 0.0889829665857455 1001 2840950
SGTC_1038 k292-0204 154 µM -1.34830266871951 0.0664673667780679 no 3119 0.0887805270694345 1000 4454212
SGTC_2997 9067075 71.4286 µM -1.35053368295547 0.066139029861903 no 3120 0.0884224284199007 983 27209819
SGTC_1837 st055472 66.5 µM -1.35826861385707 0.0650104077442427 no 3121 0.087189232803682 1004 676091
SGTC_227 fluconazole 33.516 µM -1.36698446485294 0.0637566327111005 no 3122 0.0858150874770887 1003 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_630 4356-0227 183 µM -1.36892578241895 0.0634799523635804 no 3123 0.0855112377766339 1010 779312
SGTC_3349 9149703 23.001 µM -1.3698035773457 0.0633551545272635 no 3124 0.0853741125351882 1012 4910494
SGTC_1217 1183-1422 255 µM -1.37103534447628 0.0631803539107432 no 3125 0.0851819691518151 994 2849664
SGTC_3263 9137018 49.47 µM -1.3758746378283 0.0624972415576378 no 3126 0.0844302242705539 992 43844957
SGTC_3099 9120367 49.47 µM -1.37715286785708 0.0623177720259445 no 3127 0.0842324951369925 1015 24824940
SGTC_928 2764-0428 58.7 µM -1.38012338601325 0.0619022497236497 no 3128 0.0837743289667903 1012 662578
SGTC_197 4544-0043 41.561 µM -1.38054350759159 0.0618436571826772 no 3129 0.083709681727437 1013 896523
SGTC_73 0327-0325 16.231 µM -1.38256008019451 0.0615630168891821 no 3130 0.0833998982606294 940 53298
SGTC_2307 7538926 6.34 µM -1.38417247594536 0.0613393409835048 no 3131 0.0831528245212518 990 96582
SGTC_2602 kawain 100 µM -1.38451987894756 0.061291231533837 no 3132 0.0830996627369731 988 5369129
SGTC_1135 dihydrocapsaicin 536.708 nM -1.38556639451337 0.0611464849558138 no 3133 0.0829396728383978 1006 107982 A Capsaicinoid.
SGTC_1897 st060201 15 µM -1.38579387687342 0.0611150565911518 no 3134 0.0829049263175785 1014 611878
SGTC_517 1365-0151 113 µM -1.38991089438373 0.0605484394866537 no 3135 0.0822779684925547 1003 768657
SGTC_1617 st002906 78 µM -1.39543966870428 0.0597940004468578 no 3136 0.0814416480270146 1012 5150859
SGTC_3180 9109287 49.47 µM -1.39880253854134 0.0593387282666172 no 3137 0.0809361024316989 988 18891271
SGTC_1376 2910-0861 41.3 µM -1.40111019449553 0.0590278886751778 no 3138 0.0805905617735044 1018 1112859
SGTC_1441 4106-0040 13 µM -1.40128991629734 0.0590037339934655 no 3139 0.0805636976746456 1008 2904180
SGTC_561 1550-0330 72.9 µM -1.40509731094442 0.0584938386728991 no 3140 0.0799961718195582 1013 6812934
SGTC_3330 9141424 71.43 µM -1.40643643254659 0.0583153250579599 no 3141 0.079797284098816 1007 27261020
SGTC_3001 9076041 71.4286 µM -1.40733475970501 0.0581958122204305 no 3142 0.0796640733728233 1011 16004211
SGTC_523 1934-0222 13.7 µM -1.40880779377357 0.0580002573307581 no 3143 0.0794460049803918 1019 1361595
SGTC_783 0848-0141 92.7 µM -1.41328590043712 0.0574089297919085 no 3144 0.0787858389867924 1010 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_469 w7 172 µM -1.41353388178519 0.0573763233260524 no 3145 0.0787494032073666 1013 45115570 A P450 inhibitor.
SGTC_2386 9075165 157.42 µM -1.41440034999947 0.0572625079136849 no 3146 0.0786221936962234 1014 16452277
SGTC_2160 5660466 132.927 µM -1.41858241245497 0.0567156671380078 no 3147 0.0780103981830238 1016 2859134
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.41930836289069 0.0566211632457652 no 3148 0.0779045675277772 1039 91467 include heat shock
SGTC_721 1187-1332 279 µM -1.42136391034605 0.0563542459358097 no 3149 0.077605496298957 1025 25730
SGTC_1416 3966-0321 25.3 µM -1.42181713082422 0.056295527932771 no 3150 0.0775396725706902 1015 582530 YLR208W SEC13
SGTC_3102 9121669 49.47 µM -1.42247242113316 0.0562107156090187 no 3151 0.0774445760901982 1037 41905072
SGTC_2939 9044578 71.43 µM -1.42511256741267 0.0558700293352766 no 3152 0.0770623322098004 1012 2653634
SGTC_2508 celastrol 40.54 µM -1.42648530385389 0.0556935353225049 no 3153 0.076864153009285 970 122724 Celastrol is a natural product and antioxidant.
SGTC_1383 3049-0032 20.7 µM -1.42799356012482 0.0555001250210574 no 3154 0.0766468560612912 1005 712864
SGTC_954 1189-0853 2.85 µM -1.43899013186551 0.0541059686985435 no 3155 0.07507665934283 996 2828194
SGTC_2468 5987765 72.9 µM -1.44051222627346 0.0539151991723193 no 3156 0.074861266743373 1018 26772094
SGTC_2966 9084041 48.03 µM -1.448211340503 0.0529583882832368 no 3157 0.0737789769714626 1011 17741380
SGTC_129 0088-0017 176.636 µM -1.45077272567121 0.0526430732959876 no 3158 0.0734215783794255 1016 182446
SGTC_1550 gossypolone 36.6 µM -1.45451940787621 0.0521845299105739 no 3159 0.0729011783513985 1019 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1623 st003709 20.3 µM -1.45549131990447 0.0520661006499048 no 3160 0.0727666457578706 1006 16192618
SGTC_2206 7254556 146.969 µM -1.47115297906941 0.0501869871254167 no 3161 0.070624875075198 1010 4398905
SGTC_1182 1222-0449 220 µM -1.47187370397651 0.0501018317876068 no 3162 0.0705274928933698 1017 658318
SGTC_2417 cerulenin 830 nM -1.47741591771859 0.0494508490942708 no 3163 0.0697820909431809 1018 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1572 epiandrosterone 68.9 µM -1.48119232485221 0.0490111567780417 no 3164 0.0692776654349925 1020 441302 A steroid.
SGTC_1949 st076024 69.1 µM -1.48802346754701 0.0482237365014685 no 3165 0.068372352427088 1018 2921930
SGTC_399 oxolinic acid 75 µM -1.49681244470668 0.047225562590816 no 3166 0.0672210336132682 1024 4628 A DNA gyrase inhibitor.
SGTC_999 SEC7.066 22.7 µM -1.4970634379859 0.0471973020823914 no 3167 0.067188376064468 1033 740511 YDR170C SEC7
SGTC_613 3914-0030 117 µM -1.49989823073463 0.0468790597660202 no 3168 0.0668203831855085 985 1145395
SGTC_1513 0337-0559 19 µM -1.50374284595582 0.0464502042156732 no 3169 0.0663237962426119 1023 775073
SGTC_1164 k060-0068 93.7 µM -1.50662790565089 0.046130457111451 no 3170 0.0659530301935369 1022 5963676
SGTC_3043 9092303 49.47 µM -1.50741819132581 0.0460431799973032 no 3171 0.0658517494034434 1018 25236084
SGTC_231 b-estradiol 524 µM -1.50756867976595 0.0460265754856633 no 3172 0.0658324768976404 1027 450 A steroid.
SGTC_1240 0356-0016 42.1 µM -1.50775927281732 0.0460055528378179 no 3173 0.0658080746152141 966 4305613
SGTC_2287 7945887 168.79 µM -1.50804812908548 0.0459737063419572 no 3174 0.0657711047211335 1014 1245853
SGTC_2153 5569715 200 µM -1.50904642830455 0.0458637798926641 no 3175 0.0656434591913409 1028 2054701
SGTC_2426 5582046 32.21 µM -1.51101765142919 0.0456473414959662 no 3176 0.0653919768439264 1017 2251934
SGTC_3091 9116372 49.47 µM -1.5162322819144 0.045078737585167 no 3177 0.064730313972538 1029 17169793
SGTC_538 2922-0838 53.3 µM -1.5230092691888 0.0443483068078571 no 3178 0.0638781932168185 1035 777039
SGTC_2816 7982706 58.44 µM -1.52437863262301 0.0442018800545635 no 3179 0.0637070772994283 1019 2981853
SGTC_89 0302-0250 142.109 µM -1.52493461894086 0.0441425394947823 no 3180 0.0636377030150776 1045 4203518 YLR208W SEC13
SGTC_2334 9017922 200 µM -1.52579121696623 0.044051240288658 no 3181 0.0635309343749533 1015 3163164
SGTC_136 0097-0015 404.482 µM -1.53115362121059 0.043483151370714 no 3182 0.0628657150445914 1027 4861337
SGTC_1512 0259-0544 12.2 µM -1.53186756460773 0.0434079648544818 no 3183 0.0627775594978492 1009 18476
SGTC_2181 6316240 54.2555 µM -1.53222129081324 0.0433707522857049 no 3184 0.0627339181697891 1032 12779990
SGTC_2897 9048598 12.99 µM -1.53227126258625 0.043365497251363 no 3185 0.0627277547582407 1036 6467404
SGTC_306 1672-3436 11.6 µM -1.53530588833556 0.0430473381478074 no 3186 0.0623543542198566 1035 6797378
SGTC_1001 4048-4355 44.4 µM -1.54098469165924 0.0424570233875554 no 3187 0.0616602558854938 1018 21824233
SGTC_1036 k216-0215 33.5 µM -1.54296607178081 0.0422526050691152 no 3188 0.0614195040763631 930 622330
SGTC_1377 2944-0135 198 µM -1.54366866289795 0.0421803105172778 no 3189 0.0613343108145542 1003 1894137
SGTC_2830 7992007 71.43 µM -1.54545679382526 0.0419967686133268 no 3190 0.0611179059948118 1015 1952075
SGTC_667 1498-1044 59 µM -1.54700961757164 0.0418379046965562 no 3191 0.0609304632631377 1043 6739982
SGTC_433 pimozide 108 µM -1.55505138541832 0.0410229487817306 no 3192 0.0599669158791291 1033 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3074 9116018 49.47 µM -1.55683107655267 0.0408443453475723 no 3193 0.0597552984202673 1052 17027303
SGTC_335 4077-0256 27.6 µM -1.55981736562086 0.0405460698912629 no 3194 0.0594015232533042 1004 3121989
SGTC_1017 4239-0030 168 µM -1.56187495163496 0.0403415855450743 no 3195 0.0591587251878442 1021 1149593
SGTC_2729 fluphenazine 10.66 µM -1.56320442420395 0.0402099075752449 no 3196 0.059002259926564 1022 3372 An atypical antipsychotic.
SGTC_17 0960-0276 49.807 µM -1.56467963767824 0.0400642035208336 no 3197 0.0588290226411916 1036 6821114
SGTC_407 eburnamonine 100 µM -1.56554180781392 0.0399792474156074 no 3198 0.0587279612314993 1019 3195
SGTC_1093 fluphenazine 7.97 µM -1.56575554612386 0.0399582088343243 no 3199 0.0587029284557631 1050 6602611 An atypical antipsychotic.
SGTC_304 1310-0298 97 µM -1.56670303852465 0.0398650540655344 no 3200 0.0585920601192497 1034 1550234
SGTC_3012 9080433 71.4286 µM -1.57263793498379 0.0392855604859175 no 3201 0.0579013392724404 1015 17688859
SGTC_1653 st012112 65 µM -1.57546587299377 0.0390118570321491 no 3202 0.0575744748849808 1032 720429
SGTC_2529 gangaleoidin 93.61 µM -1.57561402797158 0.0389975606839268 no 3203 0.0575573906300743 1049 4565183
SGTC_555 4296-0685 37 µM -1.58259990534441 0.0383282801240707 no 3204 0.056756342550466 1048 2908540 YHR072W ERG7
SGTC_2702 st077768 96.8 µM -1.58596254129546 0.0380094783827924 no 3205 0.0563739035611306 1020 6484119
SGTC_596 1155-0152 116 µM -1.586938892555 0.0379173196667166 no 3206 0.0562632426128049 1031 280313
SGTC_1928 4'-methoxychalcone 40.3 µM -1.58712810376086 0.0378994809501055 no 3207 0.056241816986653 1025 641818
SGTC_1518 st038567 90.8 µM -1.58780714956929 0.0378355173081091 no 3208 0.0561649771391735 1040 77966
SGTC_2182 6325192 200 µM -1.60049076839507 0.0366568728821531 no 3209 0.054744876628681 1012 736248
SGTC_486 niguldipine 82 µM -1.60133216267361 0.0365797593391822 no 3210 0.0546516845128645 1031 1236 A calcium channel blocker.
SGTC_1363 1636-0063 10.4 µM -1.60271398574367 0.0364534036475775 no 3211 0.0544989071681992 1036 6072185
SGTC_26 0302-0163 425.158 µM -1.6089853782239 0.0358844208609367 no 3212 0.0538097694388058 1059 3100915
SGTC_2652 actinonin 100 µM -1.60991816811286 0.0358004168176953 no 3213 0.0537078610770339 1048 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_15 0266-0086 27.098 µM -1.61101189767164 0.0357021243738774 no 3214 0.053588564637559 1056 1712902 YIL048W NEO1
SGTC_44 0929-0055 61.211 µM -1.61366805814979 0.0354643382863063 no 3215 0.0532997229440766 1000 1379590
SGTC_2049 5262831 67.185 µM -1.62397920063133 0.034553534060967 no 3216 0.0521901238437266 1022 763417
SGTC_2234 tolnaftate 200 µM -1.62427022905612 0.0345281083946611 no 3217 0.052159074059163 1065 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1180 1193-0155 285 µM -1.62540683943026 0.034428955741383 no 3218 0.0520379497726043 1049 2921347
SGTC_2452 5863136 48.41 µM -1.62578350131358 0.0343961491507868 no 3219 0.0519978596665784 1031 2184096
SGTC_3120 9124077 49.47 µM -1.62585406501326 0.0343900060339109 no 3220 0.0519903519306004 1062 18774327 YGL155W CDC43
SGTC_2364 9055074 200 µM -1.63703153798991 0.0334282417990654 no 3221 0.0508119399880649 1031 6470630
SGTC_1916 st067606 49.2 µM -1.63822902686324 0.0333265303828651 no 3222 0.050686963311303 1001 19590279
SGTC_274 sirtinol 40.1 µM -1.65627938200682 0.0318240181970308 no 3223 0.0488326269405381 1024 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2378 9074213 121.43 µM -1.65845055785319 0.0316471198922285 no 3224 0.0486132795672419 1031 657714
SGTC_2686 alizarin 95.37 µM -1.65987950219975 0.0315311394817373 no 3225 0.0484693479151087 1029 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2791 5663188 71.43 µM -1.66110822029886 0.0314316916009819 no 3226 0.0483458569057415 1022 54690634
SGTC_1438 4092-1045 4 µM -1.66626220819381 0.031017368063304 no 3227 0.0478306002073493 1036 1351342
SGTC_902 1120-0002 2.07 µM -1.68047480406009 0.0298981925750824 no 3228 0.0464324862663183 991 3280475
SGTC_369 0957-0393 4.5 µM -1.690318568961 0.0291428414155895 no 3229 0.0454835122375545 1039 6997992
SGTC_1151 3909-8316 15.3 µM -1.69123830376043 0.0290730836084682 no 3230 0.0453956490393626 1042 800431
SGTC_1618 st003135 44.5 µM -1.69166291741854 0.0290409253870627 no 3231 0.0453551313516467 1055 1270615
SGTC_3310 9130229 44.1445 µM -1.69286784838182 0.0289498305496099 no 3232 0.0452403122260993 1048 7761258
SGTC_402 epigallocatechin gallate 10 µM -1.69358908161613 0.0288954177940771 no 3233 0.0451716971168349 1023 65064 An antioxidant.
SGTC_3007 9078383 71.4286 µM -1.70124279341047 0.0283232111778197 no 3234 0.0444487026008639 1051 6496995
SGTC_2091 4-phenylthiadiazole 200 µM -1.70310924055047 0.0281851112876809 no 3235 0.0442738134895622 1044 270010
SGTC_1375 2910-0797 186 µM -1.70328270001969 0.0281723054026928 no 3236 0.0442575882637849 1043 742508
SGTC_2937 9044753 11.33 µM -1.70885896522507 0.0277632035541775 no 3237 0.0437385385778424 1018 6465530 YGL099W LSG1
SGTC_764 1951-2361 146 µM -1.70898981869567 0.0277536632688186 no 3238 0.0437264177130382 1026 5438930
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.70988093453451 0.0276887662757911 no 3239 0.0436439463345338 1028 3256 An antibiotic and ribosome inhibitor.
SGTC_631 k072-0230 41.5 µM -1.71239870323526 0.0275060887042597 no 3240 0.0434116089432022 1046 5773147
SGTC_395 anisomycin 6.25 µM -1.71449597118825 0.0273546888251926 no 3241 0.0432188381785921 1053 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3005 9076496 71.4286 µM -1.71502674561939 0.0273164830934565 no 3242 0.0431701617275177 1040 21368410
SGTC_619 1652-1634 108 µM -1.74326599243104 0.0253470351693805 no 3243 0.0406435813937231 1053 5400454
SGTC_920 mycophenolic acid 780.421 nM -1.76964533980903 0.0236161474543647 no 3244 0.0383931204135552 1056 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2773 thioridazine 9.09 µM -1.77062314329454 0.0235539480894785 no 3245 0.038311695389221 1050 5452 An antipsychotic.
SGTC_2247 cerulenin 830 nM -1.77497627638455 0.0232787093854112 no 3246 0.0379509022153779 1033 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2228 7354201 200 µM -1.77741089247117 0.0231259580360095 no 3247 0.0377503299650173 1069 753451
SGTC_1557 sumaresinolic acid 42.3 µM -1.78198105435344 0.0228414981088594 no 3248 0.0373761606607757 1043 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_516 3992-2719 87.3 µM -1.78757282545395 0.0224974660369559 no 3249 0.0369224764880765 1053 5350887 YDR037W KRS1
SGTC_3135 9127742 49.47 µM -1.79140692601764 0.022264107774491 no 3250 0.0366140091511303 1039 3643468
SGTC_1380 2291-0730 164 µM -1.79241943829561 0.0222028243175323 no 3251 0.0365329016815398 1046 2999191
SGTC_312 4092-0653 6.84 µM -1.80346605278751 0.0215434140349614 no 3252 0.0356575260920786 1024 1148278
SGTC_3017 9080681 49.47 µM -1.80812480798541 0.0212703206311523 no 3253 0.035293538962135 1053 16451914
SGTC_351 caspofungin 25 nM -1.80864268549247 0.0212401445743331 no 3254 0.0352532662409585 1047 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2564 betulinic acid 100 µM -1.81362162158837 0.0209518713823234 no 3255 0.0348679996668125 1059 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_787 4152-0075 138 µM -1.8202488324645 0.0205733083973055 no 3256 0.0343605598172829 1033 9566539
SGTC_482 fipronil 114 µM -1.82833754944896 0.0201191275972125 no 3257 0.0337494538389517 1066 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_347 4534-1311 26.2 µM -1.8426714822862 0.0193351572611524 no 3258 0.0326884950830595 1053 2862016
SGTC_1150 3909-7983 10.9 µM -1.89240899174315 0.0168130722510942 no 3259 0.0292182544598196 1062 23965914
SGTC_970 1315-0089 19.5 µM -1.89664112323826 0.0166120915684646 no 3260 0.0289376596005376 1053 6811083 YLR033W RSC58
SGTC_1356 1502-0781 85.8 µM -1.90109718712916 0.0164027020406952 no 3261 0.0286446419909896 1063 567702
SGTC_430 0958-0115 16.4 µM -1.9044753708583 0.01624547166103 no 3262 0.0284241506582211 1055 6833180
SGTC_1462 k081-0014 26.5 µM -1.90730513054023 0.0161147618885434 no 3263 0.0282405431098957 976 3270634
SGTC_3307 9126885 69.2785 µM -1.92886475404322 0.0151481699002655 no 3264 0.0268738272065389 1069 24824909
SGTC_1767 st044992 70.3 µM -1.93249881985696 0.0149902477602881 no 3265 0.0266489837872263 1060 9600693
SGTC_2499 avocadenofuran 51.48 µM -1.94014141275611 0.0146627431586777 no 3266 0.0261812531490573 1061 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_320 4092-0846 5.34 µM -1.94239381256555 0.0145674043529844 no 3267 0.0260447218905006 1055 1359356
SGTC_704 1310-0270 142 µM -1.94880762155162 0.0142988399784054 no 3268 0.0256592016234945 1059 5718033
SGTC_2185 6113692 200 µM -1.95342227922761 0.0141082588693135 no 3269 0.0253847892053993 1053 874150
SGTC_1641 st009299 47.1 µM -1.96303465079523 0.0137182950705579 no 3270 0.0248210739419179 1064 4046054
SGTC_1022 4477-0945 21.3 µM -1.96969066395209 0.0134537480509268 no 3271 0.024436916809712 1060 4648966
SGTC_1318 1280-3875 124 µM -1.97197784562906 0.0133638652050862 no 3272 0.0243060678216489 1061 373245
SGTC_47 0149-0135 24.25 µM -1.98083576320143 0.0130206384697212 no 3273 0.0238048473744952 1069 5239155
SGTC_1190 1486-1332 13 µM -1.98373286866716 0.0129100476593889 no 3274 0.0236428136743902 1062 4150046
SGTC_1288 0973-0013 65.5 µM -1.99068014274207 0.0126481544715908 no 3275 0.0232580315777558 1070 4315430
SGTC_497 capsazepine 133 µM -1.99820391760511 0.012369727106029 no 3276 0.0228472784991805 1063 2733484 A calcium channel blocker.
SGTC_3036 9090181 49.47 µM -2.00222417423226 0.0122231401243901 no 3277 0.0226303134254347 1074 25236586
SGTC_757 1066-0008 322 µM -2.00617167659669 0.0120806730626505 no 3278 0.0224189673181444 1048 6842497
SGTC_3210 9128157 49.47 µM -2.00682947490389 0.0120570733087257 no 3279 0.0223839116400062 1043 17590849
SGTC_1357 1503-1303 39.5 µM -2.00824316088571 0.0120064898874611 no 3280 0.0223087292950283 1068 292895
SGTC_1978 st071761 42 µM -2.01746537839792 0.0116810018109769 no 3281 0.0218234852626276 1072 5147680
SGTC_345 1362-0200 395 µM -2.02943453220077 0.0112700044163582 no 3282 0.0212070254220829 1073 1419823
SGTC_473 2-arachidonoylglycerol 10 µM -2.03530129739661 0.0110731825681526 no 3283 0.0209102828587672 1028 5282280 An endocannabinoid.
SGTC_2561 acetosyringone 100 µM -2.03848519509105 0.0109676239265499 no 3284 0.0207507169331055 1060 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2208 7283366 200 µM -2.0510729901602 0.010558816275037 no 3285 0.0201299195967091 1067 898663
SGTC_2317 5986382 200 µM -2.05386473413132 0.010469970120044 no 3286 0.0199943927090122 1071 877883
SGTC_187 1488-2104 32.728 µM -2.05496784976606 0.0104350438855371 no 3287 0.0199410550659821 1064 2852859
SGTC_2706 st078239 82.5 µM -2.07345417232675 0.00986466991061546 no 3288 0.0190650159288847 1068 15434492
SGTC_1910 st062352 60.4 µM -2.07608489058682 0.00978575607386414 no 3289 0.0189430501742057 1061 2245730
SGTC_49 0717-0965 32.132 µM -2.07829983130382 0.00971974249182759 no 3290 0.0188408759935916 1075 5889349 YGL099W LSG1
SGTC_2873 9040596 71.43 µM -2.08281144859287 0.00958648169344866 no 3291 0.0186342068088894 1072 6463863
SGTC_840 0245-0196 390 µM -2.08318178772224 0.00957561415590714 no 3292 0.0186173282656918 1077 3827528
SGTC_1131 3454-3128 32.3 µM -2.09235070607796 0.00930996622837566 no 3293 0.0182035774555052 1044 710982
SGTC_3211 9128781 49.47 µM -2.09280793709668 0.00929688949602524 no 3294 0.0181831515052816 1045 17194361
SGTC_2279 7948423 32.93 µM -2.09844405883563 0.00913701260382872 no 3295 0.0179329683508782 1063 1247112
SGTC_2419 paclitaxel 166.5 µM -2.10689394646088 0.0089018289949925 no 3296 0.0175633867345841 1057 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3123 9126162 49.47 µM -2.12256277174047 0.00847972993496203 no 3297 0.0168952536820245 1053 25239884
SGTC_867 0518-0118 155 µM -2.15471629223916 0.00766820492458628 no 3298 0.01559202104222 1065 6848158
SGTC_1714 st033236 13.627 µM -2.1580447632521 0.00758823524909144 no 3299 0.0154621758406604 1058 2916566
SGTC_2022 5136654 200 µM -2.1949819191418 0.00674888738754124 no 3300 0.014082447381053 1076 1713771
SGTC_1336 1486-0901 104 µM -2.197593132794 0.0066927814614685 no 3301 0.013989056519554 1070 5006114
SGTC_600 1495-0418 41.6 µM -2.214158461774 0.00634635723020802 no 3302 0.0134089400892501 1073 5377768
SGTC_1702 st027038 51 µM -2.2309338208815 0.00601180986064501 no 3303 0.0128427565190584 1081 5521182
SGTC_331 k048-0133 24.5 µM -2.23471140863387 0.00593866649142325 no 3304 0.0127181505705319 1076 6813582
SGTC_1444 4112-3581 28 µM -2.23695843374778 0.0058955338474674 no 3305 0.0126445284258396 1076 2877249
SGTC_1130 3454-2858 15.9 µM -2.23945628072018 0.00584791286535341 no 3306 0.0125631214594989 1065 715628 YIL048W NEO1
SGTC_157 1348-1695 65.819 µM -2.24600062582759 0.00572476051797403 no 3307 0.0123519839101218 1061 5380510
SGTC_2401 5128683 200 µM -2.24717913323779 0.00570282945690761 no 3308 0.012314290598514 1073 708373
SGTC_868 0527-0199 213 µM -2.26121280475189 0.00544734899087212 no 3309 0.011873041284351 1081 2849450
SGTC_521 r062-0005 13.8 µM -2.26127823556926 0.00544618205240018 no 3310 0.0118710165486433 1078 2832033
SGTC_2471 5466956 24.79 µM -2.2721818002601 0.00525479633554486 no 3311 0.0115377660255688 1072 724419
SGTC_989 1501-0895 10.3 µM -2.27397014882453 0.00522398385728091 no 3312 0.0114838906934874 1071 2830112
SGTC_828 2074-0507 139 µM -2.27836725392548 0.0051489061103754 no 3313 0.0113523528585759 1068 X828
SGTC_3227 9130768 49.47 µM -2.28044883974264 0.00511370046619189 no 3314 0.0112905408909506 1093 17720899
SGTC_3002 9075603 71.4286 µM -2.28061242979178 0.00511094278799203 no 3315 0.0112856955622737 1069 20105405
SGTC_1609 st001574 46.4 µM -2.28990853461671 0.00495639481830104 no 3316 0.011013309695163 1072 3960012
SGTC_2316 5844804 197.44 µM -2.29113045589514 0.00493639306109898 no 3317 0.010977934825579 1068 776813
SGTC_3113 9123498 49.47 µM -2.29528884268564 0.00486886173905915 no 3318 0.0108582883001116 1085 8897275
SGTC_350 k064-0020 19.8 µM -2.29771181969119 0.00482989388667565 no 3319 0.0107890981953663 1040 2790705
SGTC_2280 7785178 200 µM -2.31038691328816 0.00463054153456593 no 3320 0.010433371480926 1069 2954328
SGTC_147 4466-0538 29.23 µM -2.34700952927848 0.00409516305255996 no 3321 0.00946238538315996 1077 6742687 YHR072W ERG7
SGTC_2423 st077119 87.2 µM -2.3533879164397 0.00400780267423353 no 3322 0.00930160768331413 1073 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_927 2425-1185 123 µM -2.38242265744272 0.00363085870301712 no 3323 0.00859957222669325 1082 730375
SGTC_325 2810-4341 181 µM -2.3907166042739 0.00352918908549988 no 3324 0.00840776346275483 1074 774970
SGTC_2603 homopterocarpin 100 µM -2.3987325246217 0.00343336438740952 no 3325 0.00822596364855493 1073 101795 A weak amylase inhibitor.
SGTC_394 menadione 8.33 µM -2.41045038908165 0.00329748971217658 no 3326 0.00796641903176637 1068 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_921 1561-0023 372 µM -2.42460262401963 0.00313984567370337 no 3327 0.00766257560481679 1079 24050882
SGTC_1463 k081-0032 34.1 µM -2.43173985351824 0.00306294497080325 no 3328 0.00751324778371778 1036 977755
SGTC_1724 st037281 8.293 µM -2.49537351187461 0.00244876755859533 no 3329 0.00629123029967043 1068 574124 YDL195W SEC31
SGTC_1341 1486-1360 280 µM -2.50142778599025 0.00239656984314811 no 3330 0.00618468328517827 1087 3976547
SGTC_823 0417-1665 178 µM -2.51341607911394 0.0022961716025245 no 3331 0.00597841108985577 1085 3429856
SGTC_349 k015-0014 24 µM -2.53572017556032 0.0021194600916073 no 3332 0.00561081808350455 1082 2196908
SGTC_2942 9052777 62.25 µM -2.548545097863 0.00202352687009145 no 3333 0.00540866498126158 1086 6469503
SGTC_2155 5570423 76 µM -2.55683925630556 0.00196360155325376 no 3334 0.00528140076775007 1085 797402
SGTC_2014 4013930 200 µM -2.5637206066665 0.00191511209874628 no 3335 0.00517784337810803 1084 64556
SGTC_1157 4092-0394 27.6 µM -2.56886984240886 0.00187954244801602 no 3336 0.00510153859448315 1090 3659885
SGTC_1331 1472-0049 76.2 µM -2.65367805241865 0.00137386933299378 no 3337 0.00398098761567406 1081 24051409
SGTC_1955 wogonin 32.4 µM -2.6659830224428 0.00131184571339505 no 3338 0.00383817847283387 1073 5281703 A flavanone.
SGTC_599 1935-0052 86.5 µM -2.73788862286451 0.000997805508540498 yes 3339 0.00309175067581662 1087 9557311
SGTC_923 1900-2434 73.3 µM -2.82934864325725 0.000698135468428385 yes 3340 0.00233214283131221 1084 5910570
SGTC_2528 xanthyletin 44.79 µM -2.88011877199195 0.000570064805688021 yes 3341 0.00198762692053811 1087 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3206 9114350 49.47 µM -2.94313171637969 0.000441345617335919 yes 3342 0.00162455073910518 1083 17087243
SGTC_152 4469-0003 551.229 µM -2.95480719018576 0.000420681034357788 yes 3343 0.00156432255440243 1090 697280
SGTC_2013 4024628 200 µM -2.99572681292874 0.000355132064910114 yes 3344 0.00136895800033612 1085 5230760
SGTC_144 4161-2749 112.381 µM -3.03242840960628 0.000304543910061728 yes 3345 0.00121297316965609 1087 797501 YMR168C CEP3
SGTC_13 0199-0087 65 µM -3.04381747978551 0.000290264057134894 yes 3346 0.00116798408703607 1094 4589825
SGTC_2388 9080168 200 µM -3.04944429263221 0.000283441460256685 yes 3347 0.00114632573895038 1090 15943073
SGTC_3221 9128209 49.47 µM -3.18607826172517 0.000157190644678216 yes 3348 0.000721077897900555 1092 16460723
SGTC_881 0833-0569 170 µM -3.23242359446505 0.00012802898032757 yes 3349 0.000613724777840485 1093 5418700
SGTC_1147 3809-1045 12.3 µM -3.2591332649153 0.0001136119022776 yes 3350 0.000558765800879433 1094 325925
SGTC_880 0833-0487 87.2 µM -3.52311270582451 3.32640527151573e-05 yes 3351 0.000213254973143726 1094 76075
SGTC_930 2810-3379 265 µM -3.71715892031028 1.27593976281967e-05 yes 3352 0.000100737858708155 1091 1015764
SGTC_3008 9078912 71.4286 µM -4.24179178833176 7.55400935016584e-07 yes 3353 1.10871180109963e-05 1094 16648731
SGTC_2785 7756463 72.73 µM -5.73419887197162 3.62049530701751e-11 yes 3354 4.89871605105763e-09 1094 2201551
SGTC_2786 7743617 45.45 µM -9.49977652341749 1.39111155461108e-27 yes 3355 1.05170608249369e-21 1095 583674
SGTC_2783 7738165 71.43 µM -9.98820672354279 2.69766255571079e-30 yes 3356 8.58295108089578e-24 1095 17201110