SGTCid condition conc unit YLR253W|YLR253W.score YLR253W|YLR253W.strain.pval YLR253W|YLR253W.strain.significant YLR253W|YLR253W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_86 0417-1630 471.922 µM 6.57856967778888 1.48860860344091e-11 yes 1 2.37497636151916e-11 79 3634867
SGTC_2907 7721985 69.9 µM 5.10383008294908 1.27953218369291e-07 yes 2 1.66423577899533e-07 5 3267881
SGTC_635 k038-0028 24.7 µM 5.08144388946026 1.4437787392766e-07 yes 3 1.87288331226398e-07 27 4035102
SGTC_2771 fluoxetine 41.05 µM 4.97249415680875 2.58031911328302e-07 yes 4 3.30484820171244e-07 7 3386 A selective serotonin reuptake inhibitor.
SGTC_2924 9010168 62.78 µM 4.86459691476086 4.53276065977018e-07 yes 5 5.73451499482745e-07 18 2993929
SGTC_1013 4112-3890 241 µM 4.75002943846792 8.14118671558945e-07 yes 6 1.01693519193114e-06 19 705171
SGTC_1427 4048-4900 550 nM 4.6452159203897 1.37534813932659e-06 yes 7 1.69860476636081e-06 18 24132586
SGTC_367 0335-0881 7.1 µM 4.17701866203238 1.25343954122974e-05 yes 8 1.47677400873174e-05 68 23828853
SGTC_294 k038-0071 157 µM 3.99484962948773 2.79375995330784e-05 yes 9 3.23676630419048e-05 63 24152826
SGTC_1198 1612-1005 86.7 µM 3.98880709730559 2.86743071032933e-05 yes 10 3.32031970603848e-05 12 6998509
SGTC_2916 7875993 68.79 µM 3.98713298596608 2.88816477670209e-05 yes 11 3.34382718505682e-05 27 1299250
SGTC_2417 cerulenin 830 nM 3.86865430389393 4.77575780468038e-05 yes 12 5.47188355855898e-05 34 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 3.78797056297953 6.6738442591405e-05 yes 13 7.59414196622581e-05 50 6728940
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 3.78271712506697 6.81935487852898e-05 yes 14 7.75628371630173e-05 31 6708760
SGTC_3019 9081971 49.47 µM 3.67473339130799 0.000105608194525731 yes 15 0.000119048954905504 23 16451803
SGTC_340 k038-0059 454 µM 3.60013294506941 0.000141921683531152 yes 16 0.000159027260277086 56 23733424
SGTC_3087 9117406 49.47 µM 3.59169333756287 0.000146697030106043 yes 17 0.000164268155335965 29 42546093
SGTC_507 nimesulide 162 µM 3.55993674092138 0.000166047883594014 yes 18 0.000185472069875598 26 4495 A COX2 inhibitor.
SGTC_794 k038-0031 316 µM 3.50217881265655 0.000207498875860405 yes 19 0.000230734899972664 128 6624242
SGTC_2119 5528445 120.635 µM 3.40500550387237 0.000299693805457577 yes 20 0.000330813601480658 41 791935
SGTC_1010 4112-3296 15.2 µM 3.37816967501908 0.000331185863847926 yes 21 0.000364850206868558 38 704384
SGTC_2029 5175081 200 µM 3.33334269958022 0.000390736609646076 yes 22 0.000429045888056481 43 1380876
SGTC_2942 9052777 62.25 µM 3.3277719612662 0.000398794834638571 yes 23 0.000437717470793053 64 6469503
SGTC_2776 terbinafine 19.92 µM 3.31498369573176 0.00041788033363567 yes 24 0.000458242349715805 83 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_454 lyso-paf C-16 6.67 µM 3.25419893671417 0.000520734838331897 yes 25 0.000568563092466436 42 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_165 k038-0023 64.381 µM 3.24511505875785 0.000537979102206686 yes 26 0.000587015881076212 120 46368543
SGTC_2383 9036125 200 µM 3.22951751319093 0.000568825714765853 yes 27 0.000619996432619383 22 79580
SGTC_36 0335-0881 14.2 µM 3.20117391270745 0.000629100509558722 yes 28 0.000684344477254005 162 23828853
SGTC_3115 9123671 49.47 µM 3.18919739685445 0.000656299092874424 yes 29 0.000713342099055927 20 3286988
SGTC_1428 4049-0204 61.7 µM 3.1422942148167 0.00077359499247187 yes 30 0.000838147503184035 38 X1428
SGTC_3220 9131269 49.47 µM 3.13420931701436 0.00079566553998915 yes 31 0.000861589440816565 29 17722206
SGTC_2788 5282734 71.43 µM 3.12483017602091 0.000821994728952573 yes 32 0.00088953868720681 95 743706
SGTC_2306 7482397 179.52 µM 3.11374516440722 0.000854145343010971 yes 33 0.000923644831326818 53 891448
SGTC_2575 plumbagin 510 nM 3.1037056536908 0.000884257602246756 yes 34 0.000955566807380128 77 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3143 9086658 49.47 µM 3.08802072927537 0.000933260980403937 yes 35 0.00100747207660069 100 25236626
SGTC_703 3875-0075 71.8 µM 3.04615265328829 0.00107653719814135 no 36 0.00115895060598911 26 2850814
SGTC_964 1287-0107 19.4 µM 3.01660875949648 0.0011894848301234 no 37 0.00127809749983916 90 51516812 YPR165W RHO1
SGTC_1483 3453-0561 55.9 µM 2.9692967272703 0.00139313641170158 no 38 0.00149241109349851 69 4546991
SGTC_200 k038-0079 37.545 µM 2.94499648916125 0.00150968023479027 no 39 0.00161479163748727 95 3436683
SGTC_1790 st045711 43.5 µM 2.93867822003064 0.00154140569573001 no 40 0.00164807545326545 46 585119
SGTC_1786 berberine 21.6 µM 2.92964526809517 0.00158781866877342 no 41 0.00169674576662776 100 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2368 9071271 200 µM 2.86882234595617 0.00193497712702998 no 42 0.00206001569649847 91 27209959
SGTC_2425 5628681 7.85 µM 2.85948375534249 0.00199400163187137 no 43 0.00212165575223922 88 5714958
SGTC_1472 k841-0093 193 µM 2.8411055411054 0.00211495913800099 no 44 0.00224787155546955 71 X1472
SGTC_1650 st011916 45.8 µM 2.81898410085058 0.00226935825551007 no 45 0.00240879521613531 49 242528
SGTC_2486 5283202 22.39 µM 2.78763579864582 0.00250566234370782 no 46 0.00265470981608532 99 1377751
SGTC_64 000l-0018 272.079 µM 2.77568575632433 0.00260144807939379 no 47 0.00275427109414446 236 6811119
SGTC_515 4092-1064 102 µM 2.76075238912557 0.00272579161267888 no 48 0.00288341900686277 135 717353
SGTC_3255 9139072 49.47 µM 2.75625557149645 0.00276427187653175 no 49 0.00292336467215042 78 17646060
SGTC_3134 9127454 49.47 µM 2.75591784722367 0.00276718155579757 no 50 0.00292638475518219 52 24262820
SGTC_3102 9121669 49.47 µM 2.73168195845666 0.00298334467408996 no 51 0.00315059677053478 45 41905072
SGTC_2564 betulinic acid 100 µM 2.68628896336846 0.00342954503231322 no 52 0.00361252868736666 118 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2791 5663188 71.43 µM 2.6836250978714 0.00345750335763958 no 53 0.0036414361480168 85 54690634
SGTC_1994 st072947 40.9 µM 2.66204056721496 0.00369169958236232 no 54 0.00388342586135823 90 5286565 YDL195W SEC31
SGTC_2381 9035592 200 µM 2.64633399591092 0.00387096136007091 no 55 0.00406847159330175 91 4749657
SGTC_137 0438-0332 85.389 µM 2.64605055802671 0.00387426672770016 no 56 0.00407188219149578 234 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3173 9105693 49.47 µM 2.63083442503836 0.00405546783143888 no 57 0.00425877609776957 105 17096658
SGTC_2540 epiandrosterone 100 µM 2.61915690771138 0.00419963549452942 no 58 0.00440736961233605 183 441302 A steroid.
SGTC_2689 tacrolimus 100 µM 2.61701733630747 0.00422654153113421 no 59 0.00443509180588802 128 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_158 k038-0087 26.446 µM 2.61271760717109 0.00428107913418991 no 60 0.00449127441846782 250 X158
SGTC_1105 epirubicin 18.1 µM 2.6079143411644 0.00434274684497442 no 61 0.00455478736049979 89 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2088 5278280 127.392 µM 2.59628025789825 0.00449541573539608 no 62 0.00471195816108041 130 791502
SGTC_1209 2323-2347 50.3 µM 2.59114376191131 0.00456433167746636 no 63 0.00478287608300901 69 5412760
SGTC_2806 7952793 58.44 µM 2.56442735589262 0.00493821746776465 no 64 0.00516731051916701 107 2972490
SGTC_820 1582-0060 59.9 µM 2.56386321976796 0.00494639828154462 no 65 0.00517571644228404 119 3848840
SGTC_432 NS 1619 61.3 µM 2.55528476735447 0.00507229500908867 no 66 0.00530504780049049 124 4552 A K+/calcium channel activator.
SGTC_2040 5100729 123 µM 2.53262172999913 0.00541872637311741 no 67 0.00566065262059671 117 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2721 ifenprodil 61.44 µM 2.48852856950734 0.00615350674720379 no 68 0.00641364652985771 117 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2100 5377183 190 µM 2.47846795870942 0.00633304498426079 no 69 0.00659739808549907 102 2844202
SGTC_907 3448-6986 75.5 µM 2.47593599521101 0.00637895356368646 no 70 0.00664436993091809 135 590582
SGTC_2038 4100038 30.985 µM 2.46347056017964 0.00660929301774784 no 71 0.00687995974998025 143 3596803
SGTC_961 1252-1571 372 µM 2.45660694129 0.00673923458948479 no 72 0.00701280250980338 129 6813498
SGTC_3161 9100388 49.47 µM 2.44694435767066 0.00692599077661329 no 73 0.00720365396243249 77 25236368
SGTC_2333 9017922 200 µM 2.4454363232568 0.00695554630164859 no 74 0.00723384969828068 137 3163164
SGTC_2036 5160441 105 µM 2.4399242928352 0.00706452441987769 no 75 0.00734517009968012 186 134534 YIL048W NEO1
SGTC_609 0986-0026 86.3 µM 2.43605861354929 0.00714184881903729 no 76 0.00742413915578256 156 2848610
SGTC_1995 st072814 61.1 µM 2.43243368358859 0.00721503489881423 no 77 0.00749886882963307 114 5769371
SGTC_668 1682-0499 62.6 µM 2.42802967405718 0.00730483964060918 no 78 0.00759055055637719 139 682214
SGTC_12 0849-0099 9.267 µM 2.41957033766862 0.00748010690704367 no 79 0.00776942762028229 104 6071388
SGTC_920 mycophenolic acid 780.421 nM 2.36993271707539 0.00858510574763338 no 80 0.00889566128877453 157 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2949 9072542 2.23 µM 2.36661681220971 0.00866378089515137 no 81 0.00897575414978567 183 16457352
SGTC_1303 1160-0052 261 µM 2.36227552322806 0.00876774032496599 no 82 0.00908156878247711 118 3562476
SGTC_693 4161-2696 114 µM 2.36202422390727 0.00877379145173984 no 83 0.00908772726379585 81 805759
SGTC_2068 5226020 147 µM 2.36157823659719 0.00878453955527267 no 84 0.00909866588195339 179 1810509
SGTC_1283 0922-0125 16.4 µM 2.35871743724595 0.0088537584661139 no 85 0.00916910652956854 126 3360884
SGTC_2037 5169046 200 µM 2.33750298905909 0.00938213785315087 no 86 0.00970652284937893 110 5718022
SGTC_1419 3993-2473 62.6 µM 2.32654634074611 0.00966568063010775 no 87 0.00999471165809786 136 704026
SGTC_332 4112-0506 40.9 µM 2.30592556851538 0.0102196759570753 no 88 0.0105573958359307 130 2790355
SGTC_1558 st069300 45.6 µM 2.30163627256099 0.0103383300479909 no 89 0.010677846397237 87 24208000
SGTC_1464 k208-0027 110 µM 2.29436043114508 0.0105423482616973 no 90 0.0108849020146703 134 X1464
SGTC_1243 0416-0003 5.65 µM 2.28195033385974 0.0108984335710783 no 91 0.0112461363359765 183 2141977
SGTC_1438 4092-1045 4 µM 2.27930956600302 0.0109755420891909 no 92 0.0113243348943266 116 1351342
SGTC_2805 7950783 58.44 µM 2.2610690083248 0.0115212307317646 no 93 0.0118774920715062 180 1178958 YDL195W SEC31
SGTC_2896 9052656 71.43 µM 2.258243401978 0.0116078363466326 no 94 0.0119652443656938 344 6469436
SGTC_2446 5162541 200 µM 2.24921140716118 0.011888471426329 no 95 0.0122495245332194 134 1549321
SGTC_3141 9094609 49.47 µM 2.24863827392705 0.0119064763030283 no 96 0.0122677596323967 185 25236309 YDL196W YDL196W
SGTC_503 tyrphostin 8 294 µM 2.24661747114202 0.0119701483141932 no 97 0.0123322423187608 186 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2785 7756463 72.73 µM 2.227863480871 0.0125752764824064 no 98 0.01294481004513 159 2201551
SGTC_2939 9044578 71.43 µM 2.2186253747221 0.012882972940621 no 99 0.0132561108850773 193 2653634
SGTC_2591 skatole 100 µM 2.21681337553416 0.0129440836685211 no 100 0.0133179235592958 174 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2276 7947513 42.08 µM 2.21320522599184 0.0130665174357673 no 101 0.0134417499874745 174 2105100
SGTC_2623 humulene 100 µM 2.21136997789116 0.0131291752681835 no 102 0.0135051135360525 126 6187145 An anti-inflammatory.
SGTC_1925 st057770 10.1 µM 2.20791260378961 0.0132479202376763 no 103 0.0136251830350148 158 5989122
SGTC_2869 9037858 32.47 µM 2.20662187066155 0.0132924882544041 no 104 0.0136702438517149 123 27187042
SGTC_1354 1498-1681 81 µM 2.18254997555064 0.0141477163950946 no 105 0.0145344835636184 185 5754243
SGTC_1528 arabinosylhypoxanthine 74.6 µM 2.17032507739511 0.0145999115169939 no 106 0.0149911140801849 198 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 2.16919310909075 0.0146424049737011 no 107 0.0150340130435687 154 7104
SGTC_3061 glucosamine 200 µM 2.16765998152075 0.0147001273608299 no 108 0.0150922832008013 125 91431 and experimental redox chemotherapeutic
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 2.16403826994402 0.0148372630512749 no 109 0.0152307062085886 187 94937 An inhibitor of serotonin biosynthesis.
SGTC_1333 1482-0047 286 µM 2.15946829711979 0.0150118732759366 no 110 0.015406927152533 198 3811116
SGTC_3217 9129673 49.47 µM 2.15604892583848 0.0151436736232386 no 111 0.015539922495514 213 17248312
SGTC_2375 9072683 200 µM 2.15296418060061 0.015263427582371 no 112 0.0156607468673587 206 16798029
SGTC_3140 9094243 49.47 µM 2.14391597841887 0.0156193938271443 no 113 0.0160198098371654 201 19291112
SGTC_1520 flindersine 88 µM 2.14355741714609 0.0156336455500372 no 114 0.0160341829246185 195 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1891 st059073 26.2 µM 2.13596719073131 0.0159379625327875 no 115 0.0163410440850087 187 688754
SGTC_1556 plumbagin 1.48 µM 2.11886953955473 0.0166421166893973 no 116 0.0170507469181071 139 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2566 crystal violet carbinol 226 nM 2.11338428574386 0.0168735908956427 no 117 0.0172839449271951 196 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1059 3448-6867 171 µM 2.10419151251567 0.017267693983049 no 118 0.0176808723055557 171 3934407
SGTC_1572 epiandrosterone 68.9 µM 2.08328857154362 0.0181931826042746 no 119 0.0186124639137845 196 441302 A steroid.
SGTC_3029 9088683 49.47 µM 2.0830674916359 0.0182031926487767 no 120 0.0186225360248873 195 25236615
SGTC_2242 6630449 61.2675 µM 2.07452209701209 0.0185937235505525 no 121 0.0190154243653126 202 691249 YDR170C SEC7
SGTC_1827 berberine 7.24 µM 2.05771635817313 0.0193825932902383 no 122 0.0198086845797739 190 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 2.05585813633565 0.0194715402263861 no 123 0.0198980961727768 146 616764
SGTC_669 0108-0021 26.2 µM 2.05133943079965 0.0196892835189043 no 124 0.0201169515356243 340 17201
SGTC_2641 levomentholum 100 µM 2.0489856996305 0.0198035195126094 no 125 0.0202317566477809 123 16666
SGTC_3191 9110352 49.47 µM 2.04861003617903 0.0198218039200442 no 126 0.0202501312390413 165 17122424
SGTC_815 1582-0027 36.9 µM 2.0481758204833 0.0198429560500892 no 127 0.0202713873855899 197 3128206
SGTC_3145 9085516 49.47 µM 2.03872639826113 0.0203080360910072 no 128 0.0207386707930045 217 25236195
SGTC_1055 3448-0672 86 µM 2.03708694748238 0.0203896597656642 no 129 0.0208206648353228 217 748378
SGTC_535 2293-4129 48.2 µM 2.01950556833061 0.0212826027013459 no 130 0.0217173495711612 295 396118 YIL048W NEO1
SGTC_2786 7743617 45.45 µM 2.00535845792689 0.0220249309882293 no 131 0.0224623697224143 190 583674
SGTC_2665 lovastatin 100 µM 2.00427301975435 0.0220827781617703 no 132 0.0225204111817763 207 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_645 0845-0943 5.41 µM 2.00110286028473 0.0222524628558908 no 133 0.0226906530885287 196 1885106
SGTC_2774 tamoxifen 10.92 µM 1.99760596133092 0.0224409111864425 no 134 0.0228796982253196 200 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1147 3809-1045 12.3 µM 1.99724089000504 0.0224606622905308 no 135 0.0228995105471846 234 325925
SGTC_1779 st039427 55 µM 1.9957268822923 0.0225427297343835 no 136 0.0229818296610055 271 1124498
SGTC_3247 9135149 49.47 µM 1.99535330241771 0.0225630186376453 no 137 0.0230021801143718 169 8934436 YOR116C RPO31
SGTC_532 1548-0774 215 µM 1.99416837007907 0.0226274735031035 no 138 0.0230668287627283 234 5932993
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.98706007583459 0.0230173987352171 no 139 0.0234578699122666 261 23665772 A membrane-active detergent.
SGTC_1356 1502-0781 85.8 µM 1.98295698705654 0.0232450387189566 no 140 0.0236861171514698 214 567702
SGTC_1627 st003713 25.6 µM 1.97959013244088 0.0234332451231973 no 141 0.0238748013345299 350 16195070 YER133W GLC7
SGTC_1768 st044301 37.178 µM 1.96914383429762 0.024025369793383 no 142 0.0244682882109162 227 3931349
SGTC_1588 farnesol 29.9 µM 1.96760135466962 0.0241138579985621 no 143 0.0245569618776354 226 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1420 4'-methoxyflavone 42 µM 1.96628522539612 0.0241895773699182 no 144 0.0246328362562657 189 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1325 1431-0015 227 µM 1.96068765737387 0.0245138503715503 no 145 0.0249577348753371 209 1103340
SGTC_719 2810-4230 27.3 µM 1.96016583875661 0.0245442649231861 no 146 0.0249882049496772 149 721079
SGTC_1093 fluphenazine 7.97 µM 1.95998551515264 0.0245547825668207 no 147 0.0249987416683951 246 6602611 An atypical antipsychotic.
SGTC_1361 1608-0041 5.61 µM 1.95948919420394 0.024583750761788 no 148 0.0250277620685917 223 X1361
SGTC_1757 st041620 31.8375 µM 1.95497382183527 0.0248486139641467 no 149 0.0252930800986165 246 5289815
SGTC_1416 3966-0321 25.3 µM 1.95317896221647 0.0249545597225761 no 150 0.0253991965048149 244 582530 YLR208W SEC13
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.93935787374979 0.0257831350225464 no 151 0.0262288881613626 209 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1620 st003704 16.5 µM 1.93419404759254 0.026098558610938 no 152 0.0265446369893895 193 2834414
SGTC_3279 9140807 49.47 µM 1.93357396402131 0.026136651489636 no 153 0.0265827654918298 187 45595718
SGTC_276 colchicine 750 µM 1.92562366404416 0.0266291862728797 no 154 0.0270756908638778 257 2833 A microtubule depolymerizer.
SGTC_990 3985-0011 41.3 µM 1.91303400151356 0.0274249834848923 no 155 0.0278718498752217 206 5399565 YGL099W LSG1
SGTC_1000 4048-0884 8.67 µM 1.91123745217942 0.0275401447080805 no 156 0.0279870364695142 260 13040088
SGTC_1018 4259-0013 28.1 µM 1.90624103971142 0.027862542810772 no 157 0.0283094699617173 229 6801262
SGTC_1624 st003710 6.25 µM 1.90198385066328 0.0281397169213802 no 158 0.0285866329452087 304 24207033
SGTC_2984 9022109 38.96 µM 1.89801946231011 0.0283998880910448 no 159 0.0288467591429796 166 6459207
SGTC_2202 7226349 200 µM 1.89589127071683 0.0285403787359144 no 160 0.0289872117347533 187 844334
SGTC_2322 7413319 38.22 µM 1.89097822178223 0.0288669180964143 no 161 0.0293136257267958 461 1840400
SGTC_1394 3474-0001 65.7 µM 1.8897777298738 0.0289471776364987 no 162 0.0293938466084762 225 5017666 YIL048W NEO1
SGTC_2440 5628896 157.78 µM 1.88437955834962 0.0293103706780239 no 163 0.0297568264284726 227 5522048
SGTC_3263 9137018 49.47 µM 1.88433877357336 0.0293131290464827 no 164 0.029759582939101 253 43844957
SGTC_1733 st037357 54.9 µM 1.88056067220427 0.0295695872974634 no 165 0.0300158528886013 284 1272339 YGL099W LSG1
SGTC_1649 st011737 51.3 µM 1.87478221363342 0.0299654305287787 no 166 0.0304113455373249 241 1761035
SGTC_1887 st057648 70.8 µM 1.87075856506658 0.0302436509770732 no 167 0.0306892765886733 238 688672
SGTC_1380 2291-0730 164 µM 1.86601219471731 0.0305745939043807 no 168 0.0310198296876407 258 2999191
SGTC_758 0868-0029 16 µM 1.8630090933199 0.0307855316930376 no 169 0.0312304934374035 247 762687
SGTC_3109 9122853 49.47 µM 1.86100594723858 0.0309269013773428 no 170 0.0313716684211953 230 1234709
SGTC_819 1013-0258 27.7 µM 1.86062843342969 0.0309536040494239 no 171 0.0313983333272631 300 5753198
SGTC_675 1309-0189 238 µM 1.85942948415778 0.0310385358416305 no 172 0.0314831429147002 247 4246530
SGTC_1160 4092-0570 10.5 µM 1.8499556484399 0.031716451997201 no 173 0.0321599711163458 298 4994975
SGTC_185 k048-0037 25.491 µM 1.84687286481242 0.031939666476824 no 174 0.0323827841564537 228 6827589
SGTC_705 1124-0212 310 µM 1.8447705947964 0.0320926279259356 no 175 0.0325354583170081 288 9554485
SGTC_101 0490-5701 117.494 µM 1.83979153737137 0.0324573183698754 no 176 0.0328994241713528 215 4661669
SGTC_1516 st013856 110 µM 1.83928060072063 0.0324949345212153 no 177 0.0329369624294724 236 5281404 A mutagen and neurotoxin.
SGTC_886 0866-0150 153 µM 1.83528039062206 0.0327906823999908 no 178 0.0332320775160255 303 271463
SGTC_1963 st076565 50.3 µM 1.8257912331098 0.0335011279954061 no 179 0.0339408571875957 240 4914280
SGTC_2585 alliin 100 µM 1.82364182809277 0.033663800124541 no 180 0.0341031193077475 299 87310 A garlic compound which reacts with lipids.
SGTC_2635 hydroquinidine 100 µM 1.82168596850728 0.0338123886132473 no 181 0.0342513241009737 263 442912 An experimental heart treatment.
SGTC_1405 3909-7894 12 µM 1.81180572124305 0.0345712695323297 no 182 0.0350081103963602 264 7104060
SGTC_1155 4088-0394 48.2 µM 1.80993371002707 0.0347166196393983 no 183 0.0351530338771683 280 2326248
SGTC_3006 9075424 71.4286 µM 1.80987315315859 0.0347213298727181 no 184 0.0351577301498599 271 7465181
SGTC_1311 1190-0148 100 µM 1.80526157300277 0.0350815723630769 no 185 0.0355168799004527 345 1961333
SGTC_425 3825-7017 13.1 µM 1.80464084916018 0.0351302947684233 no 186 0.0355654507404588 321 3397440
SGTC_2270 7924575 90.91 µM 1.8022400969406 0.0353192596354773 no 187 0.0357538193307124 281 1262135
SGTC_1355 1499-0035 1.68 µM 1.79948755474267 0.0355369391578475 no 188 0.0359707954101693 286 1548538
SGTC_2582 agaric acid 100 µM 1.79896877632123 0.0355780886859353 no 189 0.0360118099795541 715 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2213 7173844 200 µM 1.79816710793759 0.0356417538692236 no 190 0.0360752651221868 267 892728
SGTC_2529 gangaleoidin 93.61 µM 1.79240733188046 0.0361019219013823 no 191 0.0365338705989386 249 4565183
SGTC_1555 citronellol 128 µM 1.79151688566982 0.0361734949889766 no 192 0.0366051936903398 216 8842 A terpine precursor.
SGTC_3272 9137413 49.47 µM 1.79145402479212 0.0361785520645493 no 193 0.0366102330317099 265 17614870
SGTC_3348 9149464 3.537 µM 1.78931182950873 0.0363512351599841 no 194 0.036782304996827 283 1951442
SGTC_1983 st071813 46.9 µM 1.78873671994193 0.0363977096338971 no 195 0.0368286131547657 281 11838595
SGTC_216 k038-0035 28.382 µM 1.78863791465946 0.0364056989591363 no 196 0.0368365738105208 255 4444231 YPR107C YTH1
SGTC_3339 9145883 14.936 µM 1.78288775521876 0.0368731307142864 no 197 0.0373022883607858 263 2030670
SGTC_642 0335-0876 158 µM 1.7709873818699 0.0378561049581221 no 198 0.0382814000185001 328 6812350
SGTC_2614 arthonioic acid 13.39 µM 1.77010242894399 0.0379300485529774 no 199 0.0383550395031395 271 6710684
SGTC_2513 baicalein 25.65 µM 1.7628497997043 0.0385405036334184 no 200 0.0389629128314962 295 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2889 9059656 51.95 µM 1.76192111633611 0.0386192461441663 no 201 0.0390413131618527 290 3949838
SGTC_1563 conessine 56.1 µM 1.75995989847803 0.0387859673921366 no 202 0.039207303068572 355 441082 An anti-amoebic, histamine inhibitor.
SGTC_1676 st018489 23.4 µM 1.75847757568836 0.0389123668591173 no 203 0.0393331418990604 333 3696235
SGTC_3038 9091290 49.47 µM 1.75802843435058 0.0389507318389056 no 204 0.0393713356643976 294 25236843
SGTC_3184 9108758 49.47 µM 1.75780793925151 0.0389695774687773 no 205 0.0393900970117873 242 902885
SGTC_2686 alizarin 95.37 µM 1.75753578275727 0.0389928488148887 no 206 0.0394132641202739 294 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1820 st053765 18.6 µM 1.75369890309131 0.0393221355845978 no 207 0.0397410568033946 295 3690829
SGTC_1855 st056195 39.6 µM 1.75089957967851 0.0395638025187101 no 208 0.0399816046114414 303 4028379
SGTC_1351 1496-0003 46.5 µM 1.75000652809377 0.0396411537648148 no 209 0.0400585936406064 300 3891978
SGTC_2415 st077333 57.7 µM 1.73093405091348 0.0413226691443223 no 210 0.0417317637875127 401 2766255
SGTC_2618 avocadyne 43.43 µM 1.72892592386024 0.0415030297293267 no 211 0.041911176834617 281 3015189
SGTC_2477 5967686 25.23 µM 1.72338873742268 0.0420036600490449 no 212 0.0424091251156102 324 776118
SGTC_3221 9128209 49.47 µM 1.71801909756984 0.0424937998504844 no 213 0.042896565968355 281 16460723
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.7148900118548 0.042781548756459 no 214 0.0431826971202106 274 688803
SGTC_1296 1068-0102 11.9 µM 1.71461910029813 0.0428065355299709 no 215 0.0432075422633771 311 767053
SGTC_1229 0139-0193 12.2 µM 1.71232147732481 0.0430189249354038 no 216 0.0434187204059675 344 3090752
SGTC_3104 9120930 49.47 µM 1.71106869372337 0.0431350888726379 no 217 0.0435342162787364 267 17014836
SGTC_1346 1488-2224 62.4 µM 1.71104497107943 0.043137290988713 no 218 0.0435364056923627 301 3722427
SGTC_821 1114-0266 29.2 µM 1.70712283765567 0.0435026236787778 no 219 0.0438996115692575 306 3123235
SGTC_2926 9010726 65.15 µM 1.70368100961929 0.043825271312946 no 220 0.044220348919075 342 2994293
SGTC_1951 sophoraflavanone G 9.2 µM 1.70351236095521 0.0438411304408206 no 221 0.0442361133828095 347 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1332 1480-0653 17.5 µM 1.70258895739348 0.0439280461511789 no 222 0.0443225090155639 321 5749438
SGTC_616 4092-0450 108 µM 1.69255523616426 0.0448814607907758 no 223 0.0452700788806625 351 787165
SGTC_361 000s-0510 1.45 µM 1.68805199273695 0.0453147460152834 no 224 0.0457006244021513 359 660
SGTC_1253 0550-0034 176 µM 1.68758235922317 0.0453601254905658 no 225 0.0457457139609117 325 5969915
SGTC_1878 temozolomide 1 mM 1.68531578412522 0.0455796529552723 no 226 0.0459638310074826 280 5394 DNA alkylating agent.
SGTC_254 nsc-64875 3.808 µM 1.68054906443661 0.0460441172618183 no 227 0.0464252682598263 310 56993
SGTC_2687 chenodiol 100 µM 1.67691628356084 0.0464006384975305 no 228 0.046779426736304 306 5702181 A cholesterol synthesis inhibitor.
SGTC_1058 3448-5425 97.3 µM 1.67254222183799 0.0468328459178238 no 229 0.0472087246790064 326 7279705
SGTC_1443 4112-3303 14 µM 1.67236006806724 0.0468509146017569 no 230 0.047226670661578 349 704433
SGTC_2049 5262831 67.185 µM 1.67163546778855 0.0469228464588904 no 231 0.0472981131952145 329 763417
SGTC_1098 clofazimine 15.1 µM 1.67091705144544 0.0469942518438864 no 232 0.0473690315018224 377 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_963 1269-2853 151 µM 1.66084099291351 0.048004948780672 no 233 0.0483726928737242 338 3668223
SGTC_1370 2001-0092 44.6 µM 1.65458155113934 0.0486415247137751 no 234 0.0490047041754168 411 790957
SGTC_1392 3455-1037 33.9 µM 1.64292412054967 0.0498450418672592 no 235 0.0501993168790059 337 981132
SGTC_2461 5755302 26.15 µM 1.63911132270198 0.0502437915318223 no 236 0.0505950386844036 377 2788904
SGTC_2841 9004761 38.96 µM 1.63703465047115 0.0504620410359188 no 237 0.0508116148342637 322 2991039
SGTC_965 1291-5240 308 µM 1.63616020141483 0.050554167649576 no 238 0.0509030317002745 366 2834598
SGTC_3059 1327-0034 3 µM 1.6324331296033 0.0509483326343801 no 239 0.0512941373806206 381 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3158 9100007 49.47 µM 1.62864091678554 0.0513518937521641 no 240 0.0516945285342191 300 19297233
SGTC_980 1473-0395 201 µM 1.62766401572902 0.0514562647889429 no 241 0.051798073573471 295 768876
SGTC_3296 9122258 64.045 µM 1.61379219091528 0.0529565946169894 no 242 0.0532862544835798 374 4730474
SGTC_949 1165-0505 146 µM 1.61229465856813 0.0531206165974516 no 243 0.0534489175528752 407 6244267
SGTC_1180 1193-0155 285 µM 1.60699664470673 0.0537041337200544 no 244 0.0540275520727146 363 2921347
SGTC_716 1683-5115 658 µM 1.60600202852213 0.0538142435017385 no 245 0.0541367321267538 420 723597
SGTC_713 1488-1073 324 µM 1.60508068820678 0.05391640064984 no 246 0.0542380243329299 326 3312542
SGTC_1888 azatryptophan 97.5 µM 1.60378436457715 0.0540603954335771 no 247 0.0543807960929093 306 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1559 coumarin 343 70.1 µM 1.60092839273272 0.0543787089259809 no 248 0.0546963900629487 305 108770 A hepatotoxic, DNA x-linker.
SGTC_3280 9140961 49.47 µM 1.60071339962773 0.0544027309504644 no 249 0.054720205968472 318 4901226
SGTC_1747 st037496 66.6 µM 1.59748216189398 0.0547647819126868 no 250 0.0550791354109441 409 723305
SGTC_3167 9103034 49.47 µM 1.59489560079953 0.0550559690888219 no 251 0.0553677917768929 271 5127859
SGTC_3229 9132204 49.47 µM 1.5933302419596 0.055232785731838 no 252 0.055543062889228 286 17682924
SGTC_18 0111-0177 500 nM 1.59028987954097 0.0555774941922267 no 253 0.0558847394041912 486 721752
SGTC_1514 1189-1591 158 µM 1.58711690906007 0.0559390459857641 no 254 0.0562430844570037 452 767698 YMR146C TIF34
SGTC_2557 derrustone 83.84 µM 1.58331697167766 0.0563744776913956 no 255 0.0566746182705642 437 629853 An antioxidant.
SGTC_2398 5228213 48.84 µM 1.58316338839666 0.0563921326866518 no 256 0.0566921144003534 467 80771 YMR134W ERG29
SGTC_1418 3966-3099 2.4 µM 1.58285508784376 0.0564275861881033 no 257 0.0567272486868535 403 740335
SGTC_1648 st011736 69.8 µM 1.58187694072012 0.0565401860316374 no 258 0.0568388330044856 369 2855514
SGTC_1061 3448-9325 110 µM 1.5807519046603 0.056669913908713 no 259 0.0569673876745109 329 723482
SGTC_2188 6126565 140.678 µM 1.57952489159964 0.0568116679653509 no 260 0.0571078558523827 298 874518
SGTC_2429 5902844 64.44 µM 1.5782531560342 0.056958883282715 no 261 0.0572537314410641 401 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_768 0384-0033 77.3 µM 1.57158251766989 0.057735997860804 no 262 0.0580237017514609 469 3965305 YMR134W ERG29
SGTC_783 0848-0141 92.7 µM 1.57149437650045 0.0577463216384872 no 263 0.0580339298086536 353 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2833 9001315 45.46 µM 1.5687871386342 0.0580641218469508 no 264 0.0583487731139473 422 2989378
SGTC_2217 6934799 96.0675 µM 1.56769145301373 0.0581931334236863 no 265 0.0584765786525484 348 675606
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.56721214030442 0.0582496408897685 no 266 0.0585325568417054 424 5379071
SGTC_3005 9076496 71.4286 µM 1.56621372495743 0.0583674851652453 no 267 0.0586492953182443 340 21368410
SGTC_617 3770-0098 35 µM 1.55867726571188 0.0592630743806993 no 268 0.0595363926159218 366 5962639
SGTC_3197 9113331 49.47 µM 1.55801317261813 0.0593425051523176 no 269 0.0596150627759939 415 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_941 3237-0776 460 µM 1.55734683859886 0.0594222878242539 no 270 0.0596940802539936 359 760008
SGTC_1261 0712-0010 12.7 µM 1.54816933946466 0.0605297188337064 no 271 0.0607907656115224 438 2840123
SGTC_2502 avocadyne acetate 18.59 µM 1.54383245273357 0.0610586297460688 no 272 0.0613144636194644 474 3952079
SGTC_2832 7992762 51.95 µM 1.54159117907526 0.0613333795629783 no 273 0.0615864852161919 356 2985177
SGTC_2892 9047358 58.44 µM 1.53686674953314 0.0619156937801464 no 274 0.0621629717256817 325 6466771
SGTC_2150 5556613 200 µM 1.53174548514551 0.0625517843669345 no 275 0.0627926266649946 430 743190
SGTC_1234 0326-0494 15.5 µM 1.52815612872412 0.0630006313845299 no 276 0.0632368891838127 376 1547813
SGTC_3254 9136651 49.47 µM 1.51847574398235 0.0642236678125954 no 277 0.0644472548873736 446 16454030
SGTC_846 0335-0850 148 µM 1.51772116396366 0.0643197727272384 no 278 0.064542353213444 369 6819598
SGTC_2928 9011484 9.79 µM 1.5152198708804 0.0646391421120441 no 279 0.0648583662605166 373 2994751
SGTC_1309 pyrazolanthrone 13.4 µM 1.51478216662857 0.0646951553467572 no 280 0.0649137890511198 428 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.51447177183225 0.0647348995646692 no 281 0.064953113996805 453 6708561
SGTC_1661 st013063 9.66 µM 1.51438249799612 0.0647463340615574 no 282 0.064964427818649 455 721395
SGTC_1486 3970-0793 4.53 µM 1.51071700772124 0.0652171781236765 no 283 0.0654302836389781 395 2844330
SGTC_2001 4023502 57.655 µM 1.50809262421108 0.065555917507332 no 284 0.0657654113474758 443 108941 YCR052W RSC6
SGTC_558 k064-0027 21.3 µM 1.50806345537878 0.0655596900934209 no 285 0.0657691436021895 413 5088526
SGTC_2905 7799065 20.05 µM 1.50254944996546 0.066275879212427 no 286 0.0664776335603458 371 1296806
SGTC_2110 5483698 200 µM 1.49802757520388 0.0668677145103906 no 287 0.0670630431052752 402 2848765 YHR062C RPP1
SGTC_2817 7995342 71.43 µM 1.4980231363984 0.0668682974755259 no 288 0.0670636197129341 359 18879975
SGTC_1288 0973-0013 65.5 µM 1.49672817056949 0.067038538201832 no 289 0.0672320015460453 419 4315430
SGTC_2163 5671233 125 µM 1.49626476112256 0.0670995410001753 no 290 0.0672923371055424 457 701023
SGTC_2485 5633444 17.78 µM 1.49620131859498 0.0671078958565427 no 291 0.0673006005312065 433 5724239
SGTC_2459 5811157 9.22 µM 1.49088987577377 0.0678102260971259 no 292 0.0679952049368948 400 2870684 YBR192W RIM2
SGTC_1441 4106-0040 13 µM 1.48900838321486 0.0680603723813516 no 293 0.0682425806032563 411 2904180
SGTC_1151 3909-8316 15.3 µM 1.48650078843423 0.0683948662672519 no 294 0.0685733542348236 441 800431
SGTC_3078 9116413 49.47 µM 1.47952004500066 0.0693327249559222 no 295 0.0695006890233978 395 17177322
SGTC_3299 9121982 43.1275 µM 1.47855152099483 0.0694636243987383 no 296 0.0696301088200844 443 17594604 YPL160W CDC60
SGTC_295 k015-0027 31 µM 1.47310832230436 0.0702028352812084 no 297 0.070360914870726 406 3887424
SGTC_142 0335-0849 62.6745 µM 1.46382155532138 0.0714779672160664 no 298 0.0716213556262971 573 3889043 YPR107C YTH1
SGTC_180 1486-1293 102.781 µM 1.46206536110855 0.0717210898523922 no 299 0.0718616498729246 436 4140536
SGTC_78 0336-0123 156.75 µM 1.46007313804875 0.0719976550526566 no 300 0.072134987124932 396 6765896
SGTC_3172 9105863 49.47 µM 1.45945643072344 0.0720834333749723 no 301 0.0722197620184548 314 2348785
SGTC_2404 5161160 200 µM 1.45636296899079 0.0725148880148354 no 302 0.0726461533800608 485 2831543
SGTC_473 2-arachidonoylglycerol 10 µM 1.45597308700997 0.072569406134429 no 303 0.0727000297992879 439 5282280 An endocannabinoid.
SGTC_417 st075190 100 µM 1.45374709925022 0.0728812727552186 no 304 0.0730082174290692 462 222757
SGTC_208 k072-0098 12.366 µM 1.45167922527176 0.0731719055338361 no 305 0.0732954092027678 541 5948901
SGTC_2958 9077254 16.72 µM 1.45148636693027 0.0731990562741143 no 306 0.0733222378729608 408 16457351
SGTC_859 0439-0102 54.6 µM 1.45055886447486 0.073329738441069 no 307 0.0734513683873822 480 610143
SGTC_1017 4239-0030 168 µM 1.45028151759324 0.0733688503817777 no 308 0.0734900154629622 498 1149593
SGTC_110 0850-0284 111.64 µM 1.44993670314967 0.0734174989639062 no 309 0.0735380855303552 311 3906265
SGTC_2706 st078239 82.5 µM 1.44765702301092 0.0737397514624509 no 310 0.0738564974698317 434 15434492
SGTC_998 3996-0085 177 µM 1.44620610200884 0.0739454140423724 no 311 0.0740597013675203 492 715391
SGTC_154 3389-1638 511.116 µM 1.44234453182807 0.0744949125028386 no 312 0.074602601675558 395 5238686
SGTC_3243 9134147 49.47 µM 1.437871578308 0.0751353006333595 no 313 0.0752352476408033 426 24282180
SGTC_2086 5274770 176.623 µM 1.43629442907406 0.0753620976858406 no 314 0.0754592892996317 443 689278
SGTC_2091 4-phenylthiadiazole 200 µM 1.43491375833014 0.0755610687805475 no 315 0.0756558373043953 465 270010
SGTC_2260 7964312 200 µM 1.43163946733869 0.0760345330777564 no 316 0.0761235141921875 414 231951
SGTC_3189 9110682 49.47 µM 1.42722034059664 0.0766771182282275 no 317 0.0767581966303364 454 17122418
SGTC_1510 1123-0200 71.5 µM 1.42522420859378 0.076968726274267 no 318 0.0770462003047933 544 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2426 5582046 32.21 µM 1.42340574120781 0.0772351129537199 no 319 0.0773092845656505 488 2251934
SGTC_3015 9080845 49.47 µM 1.42182912329208 0.0774666375877926 no 320 0.0775379314138569 470 5296973
SGTC_2226 7298446 200 µM 1.42099245584721 0.0775897151698594 no 321 0.0776594763274635 397 3283010
SGTC_2136 5328288 199.296 µM 1.40323379836524 0.0802372439091273 no 322 0.0802735660264703 387 262395
SGTC_3135 9127742 49.47 µM 1.3997151266612 0.0807698319263916 no 323 0.0807993211029351 444 3643468
SGTC_2047 4141938 200 µM 1.39864492753403 0.0809323460771456 no 324 0.0809597433123742 410 3807862
SGTC_1842 st055362 61.2 µM 1.39729572961428 0.0811375789403278 no 325 0.0811623297363845 514 676032
SGTC_1877 wortmannin 25 µM 1.3970611472691 0.0811733024100366 no 326 0.081197592034565 543 312145 A covalent inhibitor of PI 3-kinase.
SGTC_485 niflumic acid 177 µM 1.39576253210279 0.08137127728925 no 327 0.0813930083511274 449 4488 A COX2 inhibitor.
SGTC_2299 7976368 114.88 µM 1.39119178784467 0.0820709881047003 no 328 0.0820836384149432 460 2979718
SGTC_761 k216-0224 480 µM 1.38787947831768 0.0825808777752177 no 329 0.0825868739000849 510 1340404
SGTC_1817 st052116 64.4 µM 1.38546480925808 0.0829540867671133 no 330 0.0829551928944316 469 4361398
SGTC_1408 3909-7976 48.8 µM 1.38309066141757 0.0833222684217401 no 331 0.0833185343735113 537 24152374
SGTC_1996 st072960 66.8 µM 1.38291331910694 0.0833498198076994 no 332 0.0833457229264999 506 1719405
SGTC_341 1486-1430 230 µM 1.38262868648704 0.0833940538194722 no 333 0.0833893742211888 480 2054753 YPL210C SRP72
SGTC_346 4513-0042 7.16 µM 1.38197013165003 0.0834964657442754 no 334 0.0834904361462581 520 2827372
SGTC_2762 leflunomide 42.06 µM 1.37980572947406 0.0838337179320853 no 335 0.0838232340388373 533 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2062 5245942 200 µM 1.378428411239 0.0840488605573054 no 336 0.0840355282647923 516 1376160
SGTC_350 k064-0020 19.8 µM 1.37696830759082 0.0842773869663047 no 337 0.0842610232377646 528 2790705
SGTC_1022 4477-0945 21.3 µM 1.37515192519756 0.0845623264248615 no 338 0.0845421745419939 508 4648966
SGTC_1910 st062352 60.4 µM 1.37495437254884 0.0845933604154531 no 339 0.0845727953877751 497 2245730
SGTC_950 1165-0508 94.1 µM 1.36971473961641 0.0854195873834443 no 340 0.0853879828763353 478 6148369
SGTC_2198 6589944 200 µM 1.36765784504565 0.0857455818370459 no 341 0.0857096004472667 390 5290268
SGTC_2297 7971671 152.32 µM 1.3666316932589 0.0859085630529628 no 342 0.0858703889815676 478 909016
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.36356723912122 0.0863966628304006 no 343 0.0863519044063163 541 2724 A muscle relaxant with antifungal properties.
SGTC_2349 9023730 187.07 µM 1.36314050897189 0.086464795661968 no 344 0.0864191160448533 489 4126287
SGTC_228 caffeine 993.056 µM 1.36294796789867 0.0864955504126343 no 345 0.0864494548068416 451 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_335 4077-0256 27.6 µM 1.35990884148446 0.0869820765623483 no 346 0.0869293863781963 582 3121989
SGTC_2279 7948423 32.93 µM 1.35900443126388 0.0871272552807107 no 347 0.0870725922651806 452 1247112
SGTC_3250 9135583 49.47 µM 1.35722528904919 0.0874133766735369 no 348 0.0873548188432767 477 7699353
SGTC_1955 wogonin 32.4 µM 1.3553779190127 0.0877112120485448 no 349 0.087648590524271 477 5281703 A flavanone.
SGTC_619 1652-1634 108 µM 1.35252478379538 0.0881726847231494 no 350 0.0881037479561725 474 5400454
SGTC_3321 9137793 26.8275 µM 1.34661600881423 0.0891341348605443 no 351 0.0890519677678685 539 4904192
SGTC_466 geldanamycin 89.2 µM 1.3462344752369 0.0891964834505226 no 352 0.0891134550197196 378 5288382 HSP90 inhibitor.
SGTC_2725 haloperidol 53.21 µM 1.34605423225276 0.0892259492746385 no 353 0.0891425136350916 513 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1404 3909-7820 48.3 µM 1.34325404223234 0.0896846504154416 no 354 0.0895948639509365 504 23741373
SGTC_2222 6885208 172.143 µM 1.34130999372228 0.0900041359772447 no 355 0.089909913215992 452 609514
SGTC_1467 k284-1082 293 µM 1.33702554897943 0.0907112273802353 no 356 0.090607148663297 544 3334705
SGTC_2722 naftopidil 47.16 µM 1.33058757334759 0.0917814703034605 no 357 0.0916623768019235 540 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1144 3486-0183 12.5 µM 1.32898754012034 0.0920489037516143 no 358 0.0919260403235066 576 6744069
SGTC_1853 st056710 91.2 µM 1.32863842302107 0.0921073326379484 no 359 0.0919836446048967 534 269167
SGTC_1711 st032263 62.8 µM 1.32605485191563 0.0925405776010004 no 360 0.092410764603507 505 3958979
SGTC_427 1354-0053 47.3 µM 1.32193283812543 0.093234926132899 no 361 0.0930952581769453 526 6813657
SGTC_2436 5633522 8.09 µM 1.32137658302123 0.0933289206917215 no 362 0.0931879150283158 558 5724242
SGTC_2116 5511452 16.8835 µM 1.32030332794936 0.0935104743896709 no 363 0.0933668824596329 538 870744
SGTC_518 1021-0119 62.6 µM 1.31906513808248 0.0937202526374039 no 364 0.0935736683855927 532 1097762
SGTC_1412 3909-8563 178 µM 1.31751443378536 0.0939834679083992 no 365 0.093833123067934 586 23767530
SGTC_373 0844-0104 25.9 µM 1.3168219745463 0.0941011814001757 no 366 0.0939491526084386 570 5375804
SGTC_1519 esterone 74 µM 1.3162451452264 0.0941993215880242 no 367 0.094045887831447 542 698 A steroid.
SGTC_1038 k292-0204 154 µM 1.31618485970066 0.0942095827612501 no 368 0.094056002053304 494 4454212
SGTC_2992 9074591 71.4286 µM 1.31534765461189 0.0943521683187436 no 369 0.0941965445815741 516 17741321
SGTC_255 tunicamycin 200.472 nM 1.31013951345036 0.0952427499889222 no 370 0.0950743217033919 558 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1175 0741-0056 27.6 µM 1.31000227012768 0.0952663017383303 no 371 0.0950975338110661 604 765927
SGTC_1861 st057647 17.4 µM 1.30679855481099 0.0958172968243326 no 372 0.0956405680664396 551 688668
SGTC_416 estradiol valerate 100 µM 1.30670331925862 0.0958337118357774 no 373 0.0956567454757603 518 13791 A steroid.
SGTC_714 4296-0578 26.1 µM 1.30668935636997 0.0958361186841536 no 374 0.0956591174836481 443 1589775
SGTC_935 2996-0153 430 µM 1.30586807829176 0.095977764456453 no 375 0.0957987119013604 531 23738523
SGTC_316 k060-0003 58.6 µM 1.30392435358918 0.096313611757359 no 376 0.096129687903389 523 6152314
SGTC_1931 st074438 57.1 µM 1.3009985301728 0.0968207787616023 no 377 0.0966294789185257 507 2787313
SGTC_2601 securinine 100 µM 1.29718694421542 0.0974844230944339 no 378 0.0972834358899899 537 442872 A GABA receptor antagonist.
SGTC_3174 9107204 49.47 µM 1.29702228367824 0.0975131675270207 no 379 0.0973117598271177 540 3938802
SGTC_774 k060-0086 136 µM 1.29171078547745 0.0984437213148685 no 380 0.098228660472814 617 5911235
SGTC_1989 st071868 50.2 µM 1.28987344108168 0.0987671257790495 no 381 0.0985473017558836 564 16414057
SGTC_3113 9123498 49.47 µM 1.2834329489071 0.0999069029371883 no 382 0.0996702182792549 544 8897275
SGTC_749 1000-0129 128 µM 1.28293762412736 0.0999949569963851 no 383 0.0997569650247084 601 708470
SGTC_3041 9091929 49.47 µM 1.28204192648787 0.100154329352618 no 384 0.0999139695104529 573 25236887
SGTC_2770 toltrazuril 17.5 µM 1.27794257784708 0.100886097159036 no 385 0.100634836905995 590 68591 Kills coccidiodes.
SGTC_2364 9055074 200 µM 1.27706299669752 0.101043616378723 no 386 0.100790003700073 516 6470630
SGTC_618 k072-0232 33.2 µM 1.27660640913105 0.101125454714185 no 387 0.100870619007186 533 5872756 YGL099W LSG1
SGTC_1452 4194-0072 190 µM 1.27309505071107 0.101756442096109 no 388 0.101492157504767 629 1343545
SGTC_1736 st036774 51 µM 1.27154463002036 0.102035961394062 no 389 0.101767480304675 599 1272247
SGTC_2753 fluvastatin 17.09 µM 1.27048461801053 0.102227388125045 no 390 0.101956029305692 576 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_793 0488-0545 106 µM 1.27015474226935 0.10228701338755 no 391 0.102014757590615 574 292548
SGTC_2857 9024691 58.44 µM 1.26974560740778 0.102360999924545 no 392 0.102087630691496 529 16478292
SGTC_890 0929-0006 47.2 µM 1.26924629119303 0.102451347267891 no 393 0.102176617761867 542 1378169
SGTC_1810 st050138 53 µM 1.26605169892667 0.103030756083743 no 394 0.102747286832194 516 3444541
SGTC_892 0929-0076 29 µM 1.26599289224391 0.1030414442203 no 395 0.102757813488556 618 5751038
SGTC_2332 7982454 138.89 µM 1.25956944620656 0.104213761105863 no 396 0.103912361676315 596 2981748
SGTC_1699 st031318 29.054 µM 1.2595690776747 0.104213828641319 no 397 0.103912428184915 556 5340658
SGTC_2887 9044784 58.44 µM 1.25949758635619 0.104226930412207 no 398 0.103925330740286 594 6465546
SGTC_189 3970-0742 2.116 µM 1.25766695808616 0.104562825116004 no 399 0.104256113347641 553 2891807
SGTC_2095 5432005 200 µM 1.25318870494582 0.105387825983257 no 400 0.105068519784921 523 783734
SGTC_245 methotrexate 289.6 µM 1.25091261171347 0.105808936781005 no 401 0.105483181034764 631 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2792 7535235 81.82 µM 1.25017490837551 0.105945683415115 no 402 0.105617830304308 538 1281891
SGTC_1893 st059353 36.1 µM 1.24918052418935 0.106130212519411 no 403 0.105799526843759 588 3112488
SGTC_1254 0550-0035 264 µM 1.24854596671256 0.106248089431505 no 404 0.105915592918907 627 15121435
SGTC_1723 st034307 2.5525 µM 1.24665744746716 0.106599464711606 no 405 0.106261563889897 571 867466
SGTC_2673 kobusone 100 µM 1.24408237139315 0.107079930335104 no 406 0.106734624192176 570 6710676 An epoxy ketone and protein crosslinker.
SGTC_2906 7926292 26.41 µM 1.2434678993841 0.107194810870691 no 407 0.106847731450688 583 2966319
SGTC_1725 st036284 20.55 µM 1.24122953979954 0.10761404185297 no 408 0.107260482637409 653 707914
SGTC_875 0709-0210 25.7 µM 1.23987287791501 0.107868710588201 no 409 0.107511208540297 640 6251364
SGTC_2190 6049624 200 µM 1.23460177622871 0.108862305981098 no 410 0.108489373814528 522 2265554
SGTC_2282 7944268 200 µM 1.23260550848694 0.109240312335226 no 411 0.108861490385219 626 2970414
SGTC_1233 0325-0408 14.2 µM 1.23045858404815 0.109647898005496 no 412 0.109262713464047 584 12874
SGTC_111 0083-0039 52.457 µM 1.22852645479525 0.110015638036887 no 413 0.109624702358247 445 759313
SGTC_2096 5468907 200 µM 1.2258903601705 0.110518789078787 no 414 0.110119968445274 587 759785
SGTC_2835 9006588 71.43 µM 1.22578037877486 0.110539817001953 no 415 0.110140666433564 590 2345538
SGTC_1729 st035615 45.989 µM 1.21540569384169 0.112536320393072 no 416 0.112105698730414 588 17385451
SGTC_3353 9151644 39.2805 µM 1.21322070046427 0.112960063575925 no 417 0.112522725897015 623 4909158
SGTC_3110 9122132 49.47 µM 1.20953528178126 0.113677367478408 no 418 0.113228632422804 619 918317
SGTC_25 0118-0223 35.662 µM 1.20747160067567 0.114080443085456 no 419 0.113625287815927 594 5333628
SGTC_572 0960-0087 17.7 µM 1.20633076502886 0.114303706154447 no 420 0.113844989919776 649 6796365
SGTC_1605 st000082 49.1 µM 1.20619604782322 0.11433009101766 no 421 0.113870953727887 604 1114022
SGTC_989 1501-0895 10.3 µM 1.20521492455085 0.114522378442265 no 422 0.114060171150272 608 2830112
SGTC_480 am 92016 50 µM 1.20416481416157 0.114728441363536 no 423 0.114262941329795 558 2129 K+ channel blocker.
SGTC_1816 st051957 91.6 µM 1.20081136130105 0.115388254659466 no 424 0.11491219186432 624 674121
SGTC_2715 st079500 56.4 µM 1.20011897688108 0.115524820939248 no 425 0.115046568219794 578 28246688
SGTC_2996 9066192 71.4286 µM 1.19660567372834 0.116219556572824 no 426 0.11573014398767 610 6472854
SGTC_2117 5521686 200 µM 1.19334571418143 0.116866842091669 no 427 0.116367002978817 620 803312
SGTC_3010 9080089 71.4286 µM 1.192608911298 0.117013492308621 no 428 0.116511287103026 635 17027233
SGTC_497 capsazepine 133 µM 1.19228720415481 0.117077564458215 no 429 0.116574325052772 607 2733484 A calcium channel blocker.
SGTC_2353 9059630 146.67 µM 1.18898955166974 0.117735768353178 no 430 0.117221889232992 605 4779114
SGTC_745 0469-0705 296 µM 1.18638368905562 0.11825774175638 no 431 0.117735405067901 716 3486736
SGTC_1506 4226-2149 212 µM 1.18515600126638 0.118504222822929 no 432 0.117977886287528 694 991114
SGTC_592 k241-0073 46.5 µM 1.18475282313033 0.118585247443633 no 433 0.118057595205936 671 4230158
SGTC_442 cape 100 µM 1.18346989725044 0.118843330854627 no 434 0.118311484984383 583 5281787
SGTC_2592 piperlongumine 83.33 µM 1.17988951817898 0.119565685656139 no 435 0.119022079646929 586 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2606 farnesol 9.78 µM 1.17917470281064 0.119710272430896 no 436 0.11916430855076 647 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2558 carylophyllene oxide 100 µM 1.17768384393748 0.120012227344294 no 437 0.119461335057895 681 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2966 9084041 48.03 µM 1.17716657279525 0.120117119513946 no 438 0.11956451387801 594 17741380
SGTC_3181 9108277 49.47 µM 1.17488946494541 0.120579639262053 no 439 0.120019470477557 613 17097298
SGTC_1744 st037937 38.9 µM 1.17106871397163 0.121358513997097 no 440 0.120785579123831 634 1016152
SGTC_627 1391-0720 175 µM 1.16919284284309 0.121742209541082 no 441 0.121162972066932 634 997839
SGTC_536 3852-0578 10.6 µM 1.16909565344407 0.121762112111994 no 442 0.121182547472738 656 2869208
SGTC_2504 purpurogallin 52.29 µM 1.1670292088876 0.122185822437301 no 443 0.121599287009258 604 5281571 An antioxidant.
SGTC_1191 1487-1166 10.6 µM 1.16551684773396 0.122496577074744 no 444 0.121904922290367 741 3955771
SGTC_2307 7538926 6.34 µM 1.16542990536242 0.122514458528526 no 445 0.121922508989306 670 96582
SGTC_1 0258-0098 57.368 µM 1.16513612137803 0.122574894685832 no 446 0.121981948785272 564 6790032 YDR047W HEM12
SGTC_1473 k844-0725 134 µM 1.16511716630127 0.12257879477247 no 447 0.121985784566857 734 54682906
SGTC_2870 9038528 12.99 µM 1.1632074817413 0.122972166702706 no 448 0.122372665863127 580 6463316
SGTC_1119 parthenolide 318.541 nM 1.15904882913499 0.123831858817542 no 449 0.123218141057185 726 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1783 st039459 87.517 µM 1.15884729763983 0.123873626770455 no 450 0.12325921717318 715 729761
SGTC_2624 nerol 100 µM 1.15684608245729 0.124288919258561 no 451 0.123667625269714 630 637566 A natural product oil.
SGTC_2480 5767542 37.17 µM 1.15655059481758 0.124350321311205 no 452 0.123728008592398 673 2867358
SGTC_3239 9133757 49.47 µM 1.14763705324332 0.126212525536393 no 453 0.125559213383951 667 17036923
SGTC_610 4215-0184 155 µM 1.14639260087299 0.126474052962261 no 454 0.125816371421851 705 5605015
SGTC_1208 2323-2347 50.3 µM 1.14318248453155 0.127150415964117 no 455 0.126481416483389 699 5412760
SGTC_318 1488-0629 67.2 µM 1.13943363038763 0.127943470359898 no 456 0.127261167854295 634 3662576
SGTC_1640 st009078 66.4 µM 1.13924177924625 0.127984147901421 no 457 0.127301162117759 597 690618
SGTC_2194 5927483 104.545 µM 1.1376763168961 0.128316403315736 no 458 0.127627833097342 708 760979
SGTC_3276 9139060 49.47 µM 1.1335130084031 0.129202941043904 no 459 0.128499440769129 627 4870619
SGTC_2755 lomerizine 42.69 µM 1.13321339276697 0.129266904778144 no 460 0.128562325654329 702 3949 A calcium channel blocker.
SGTC_2895 9054447 58.44 µM 1.12900927682135 0.130166739633338 no 461 0.129446960147973 656 2697450
SGTC_2137 5261020 140 µM 1.12887273498787 0.130196037083429 no 462 0.129475761968838 656 763655
SGTC_2419 paclitaxel 166.5 µM 1.12596680311269 0.130820637895254 no 463 0.130089785526778 723 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_760 0568-0725 82.9 µM 1.12594466175674 0.130825404893391 no 464 0.130094471719568 727 3916171
SGTC_1839 st053978 48 µM 1.12439997896056 0.131158268986019 no 465 0.130421690492094 669 3788398
SGTC_2893 9048488 25.97 µM 1.12262886349891 0.131540646465937 no 466 0.130797575777607 659 6467338
SGTC_700 3453-2283 142 µM 1.12138544395701 0.131809555589616 no 467 0.13106191468373 739 565664
SGTC_477 mead ethanolamide 10 µM 1.12074599101199 0.13194799496721 no 468 0.131197999771725 524 16061185
SGTC_851 0394-0702 453 µM 1.11980802134313 0.132151243583855 no 469 0.131397790169001 743 762646
SGTC_2363 9053361 176 µM 1.11775042204458 0.132597860548908 no 470 0.131836800625142 693 6469797 YMR079W SEC14
SGTC_1048 3161-0300 24.5 µM 1.1177130489623 0.132605982252943 no 471 0.131844783910859 704 2165101
SGTC_3045 9092950 49.47 µM 1.11639836804206 0.132891899252705 no 472 0.132125825883119 742 44120432
SGTC_257 daunorubicin 18.5 µM 1.11613113851665 0.132950068238858 no 473 0.132183002550524 678 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1328 1441-0025 69.2 µM 1.1115795173524 0.133943531408561 no 474 0.133159491639925 641 4562601
SGTC_2325 6158266 200 µM 1.11032553926941 0.134218125970066 no 475 0.133429385822399 670 3623240
SGTC_3285 9112818 20.8695 µM 1.10999997354134 0.134289481128547 no 476 0.133499518943481 742 17017947 YPR165W RHO1
SGTC_2067 5224629 34.075 µM 1.10976933536717 0.134340046510068 no 477 0.133549218182979 676 2835000
SGTC_285 1486-1325 46 µM 1.10842140629939 0.134635829533756 no 478 0.133839932158891 742 22310230
SGTC_3355 9151058 44.0485 µM 1.10566218652876 0.135242692425623 no 479 0.134436381311966 683 17015728
SGTC_1621 st003705 32.4 µM 1.10477548799441 0.135438110466566 no 480 0.134628442150344 766 24207032
SGTC_1965 Pectolinarigenin 58.4 µM 1.10464989721552 0.135465804850401 no 481 0.134655660605326 708 5320438 An anti-inflammatory.
SGTC_266 formosanin C 406 nM 1.10405515983405 0.135597004799597 no 482 0.13478460537219 713 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_201 4262-0159 12.803 µM 1.10344662350962 0.135731338897177 no 483 0.134916629548598 619 1341029
SGTC_1321 1326-2144 215 µM 1.10300455380035 0.135828982712965 no 484 0.135012593796244 684 3513030
SGTC_988 1497-1057 103 µM 1.10110703017825 0.136248651714721 no 485 0.135425038841348 727 3533044
SGTC_1634 st006576 41 µM 1.09850433012076 0.136825724045862 no 486 0.135992163948946 706 3915356
SGTC_2975 9084847 53.72 µM 1.09651375517783 0.137268201559895 no 487 0.136427003555814 725 27211724
SGTC_1075 aripiprazole 15.2 µM 1.09572642083926 0.137443484613538 no 488 0.136599258365667 760 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2793 7325131 81.82 µM 1.09549598695908 0.137494814655882 no 489 0.136649701340125 673 4176441
SGTC_2254 7938975 95.19 µM 1.09184038414308 0.138310865151242 no 490 0.137451632536133 800 2969277
SGTC_2684 capsaicin 100 µM 1.08997664825197 0.13872818032339 no 491 0.137861715337898 681 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3236 9132701 49.47 µM 1.08808093200648 0.139153535315207 no 492 0.138279690351157 719 24282524
SGTC_169 k015-0017 16.025 µM 1.08734625993626 0.13931861718099 no 493 0.138441905782379 644 1840002
SGTC_2035 5154463 94.595 µM 1.08638361070781 0.139535127451259 no 494 0.138654654741868 735 2769623
SGTC_712 r015-0009 80.6 µM 1.08469295845387 0.139915927118152 no 495 0.139028833814604 659 6813872 YLR060W FRS1
SGTC_2267 7931562 200 µM 1.08259844861738 0.140388669656988 no 496 0.13949334810829 647 934880
SGTC_1185 1319-0113 81.3 µM 1.08232152926055 0.140451252980618 no 497 0.13955484139359 667 4672763
SGTC_1203 3992-3522 103 µM 1.08209206407163 0.140503126088419 no 498 0.13960581087386 760 5322312
SGTC_837 0091-0265 12.5 µM 1.0809338092233 0.140765160725909 no 499 0.139863279036033 754 759367
SGTC_353 1988-1175 58.3 µM 1.0809105356925 0.140770429346091 no 500 0.139868455808534 670 2788357
SGTC_829 1635-0120 117 µM 1.08005845186801 0.14096341468441 no 501 0.140058075986637 756 285054
SGTC_1876 myriocin 605 nM 1.07932494479493 0.141129687677887 no 502 0.140221448283996 733 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_786 4544-0069 423 µM 1.07811959171251 0.141403208486804 no 503 0.140490194749609 753 748821 YLR208W SEC13
SGTC_2055 5235184 200 µM 1.07751221915172 0.141541170560161 no 504 0.140625747420928 719 2836034
SGTC_2818 7996756 12.99 µM 1.07724205815212 0.141602565769104 no 505 0.140686070139626 642 2241621
SGTC_3053 9095903 49.47 µM 1.07717044303213 0.141618843627236 no 506 0.140702063618014 731 17174018
SGTC_112 phenothiazine 287.218 µM 1.0763587010711 0.141803438261119 no 507 0.140883432505023 756 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1221 2958-7315 257 µM 1.07618645100967 0.14184262983036 no 508 0.14092193901836 705 4562705
SGTC_2872 9044037 25.97 µM 1.07486440199127 0.14214367608976 no 509 0.141217720843517 690 6465195
SGTC_2812 7970281 58.44 µM 1.07336113041891 0.142486513927016 no 510 0.141554558615041 737 2233435
SGTC_1749 st037932 54.2 µM 1.07046841373388 0.143147802638422 no 511 0.142204259609432 679 594497
SGTC_1070 indatraline 8.81 µM 1.07029571056173 0.143187348876943 no 512 0.142243112284877 728 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_3072 9116419 49.47 µM 1.06935174451307 0.143403632256835 no 513 0.142455601294637 642 17170162
SGTC_1285 0929-0069 65.5 µM 1.06919713798261 0.143439077024141 no 514 0.1424904240453 728 1206237
SGTC_1414 3917-0015 5.4 µM 1.0674434379963 0.143841540636858 no 515 0.142885821106765 721 6618702
SGTC_3074 9116018 49.47 µM 1.06636114982971 0.144090299066701 no 516 0.143130208336108 694 17027303
SGTC_3098 9119039 49.47 µM 1.06525347204949 0.144345193380139 no 517 0.143380620915376 734 17161528
SGTC_1178 0988-0033 191 µM 1.06076002734627 0.14538232225131 no 518 0.144399486160568 753 5392207
SGTC_2645 abamectin 100 µM 1.06060978979504 0.145417084859727 no 519 0.144433635831347 714 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1101 ebselen 5.29 µM 1.05946491629367 0.145682174227538 no 520 0.14469404947641 800 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_855 0428-0020 25 µM 1.05872557633666 0.145853537000075 no 521 0.144862388162285 683 6812414
SGTC_133 0724-0033 378.92 µM 1.05681934816052 0.146295983539894 no 522 0.145297021157383 706 280309
SGTC_720 r052-1644 49.9 µM 1.05420463379502 0.14690433835992 no 523 0.145894619499173 666 1422863 YOR257W CDC31
SGTC_511 blebbistatin 171 µM 1.05352241385267 0.147063346380604 no 524 0.14605081359025 738 3476986 A myosin inhibitor.
SGTC_2701 st077767 14.721 µM 1.05280844776045 0.147229877156795 no 525 0.146214396217498 784 5721188
SGTC_3268 9137683 49.47 µM 1.05269505232236 0.147256337982312 no 526 0.146240388495792 726 1953228
SGTC_222 nsc-310342 10.666 µM 1.05261550826603 0.147274901490053 no 527 0.146258623278958 659 432556
SGTC_1602 st001878 87.6 µM 1.05259327132469 0.147280091292605 no 528 0.146263721177461 751 595405 YLR310C CDC25
SGTC_3298 9116858 71.43 µM 1.05236363250172 0.147333693069391 no 529 0.146316373679569 775 2506942
SGTC_37 0566-0070 1.56 µM 1.0522413998783 0.147362229663959 no 530 0.146344404850898 803 1626686
SGTC_1284 0929-0043 16 µM 1.05166616437119 0.147496574657744 no 531 0.146476369967951 760 1239883
SGTC_1084 voriconazole 435 nM 1.05070250399296 0.147721819253705 no 532 0.146697622813808 770 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1322 1348-1070 12 µM 1.0476358905235 0.148440137316813 no 533 0.147403197502025 724 6758089
SGTC_1818 st052136 56.3 µM 1.04219384664553 0.149720614054457 no 534 0.148660907671749 723 674169
SGTC_1116 jasmonic acid 1.58368 µM 1.04068594886583 0.150076712299493 no 535 0.149010663299925 779 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_3082 9117008 49.47 µM 1.04062974644608 0.150089995711871 no 536 0.149023710021749 767 41448529
SGTC_2187 6125751 200 µM 1.03514822660318 0.151389316612119 no 537 0.150299846574411 766 874498
SGTC_1067 clotrimazole 1.36 µM 1.03226525514374 0.152075679167181 no 538 0.150973936468108 788 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2256 7954252 200 µM 1.03107243136454 0.15236026380842 no 539 0.151253427405693 668 2972920
SGTC_3349 9149703 23.001 µM 1.02261870023519 0.154387285117709 no 540 0.15324408218311 754 4910494
SGTC_3256 9138902 49.47 µM 1.02233522942347 0.154455562816489 no 541 0.153311132347139 813 17228773
SGTC_2690 usnic acid 100 µM 1.02081573123811 0.154821894311019 no 542 0.15367087490483 841 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2166 5933061 31.504 µM 1.02064830737665 0.154862293129664 no 543 0.153710546808805 746 2877375
SGTC_1689 st020265 53.493 µM 1.01957006174573 0.15512263701396 no 544 0.153966204825228 795 5758320 YPR016C TIF6
SGTC_10 0279-0212 42.575 µM 1.01938297824894 0.155167837981235 no 545 0.154010591988119 878 39851 YBR002C RER2
SGTC_954 1189-0853 2.85 µM 1.01934187890642 0.155177769097441 no 546 0.154020344293542 811 2828194
SGTC_1813 st051246 8.6015 µM 1.01913075784249 0.155228790342698 no 547 0.154070446841396 767 5291959
SGTC_1800 st050079 29.0735 µM 1.01568652866744 0.156062714704148 no 548 0.154889342534652 889 3645560
SGTC_474 dl-dihydrosphingosine 5 µM 1.01532959964856 0.156149303666101 no 549 0.154974369639661 772 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1474 0330-0125 5.35 µM 1.01284675638382 0.15675250321234 no 550 0.155566681755031 795 X1474
SGTC_2098 5376439 882.5 nM 1.01167981306409 0.157036537754662 no 551 0.155845585312886 837 2844116
SGTC_1293 1000-1278 195 µM 1.00999420562774 0.157447412676029 no 552 0.156249033073551 817 678847
SGTC_659 k018-0002 107 µM 1.00918466371245 0.157644993335242 no 553 0.1564430401442 811 6797879 YHR007C ERG11
SGTC_2261 9010538 184.68 µM 1.00874376192123 0.157752670416384 no 554 0.15654876914567 677 6457250
SGTC_2013 4024628 200 µM 1.00167347417555 0.159485974033454 no 555 0.158250660993997 728 5230760
SGTC_1450 4112-4260 37.6 µM 0.997274881447883 0.160570569893659 no 556 0.159315551310903 842 1633175
SGTC_1802 st050112 57.9 µM 0.994398674009296 0.161282378313629 no 557 0.160014406717763 811 4662563
SGTC_1087 pterostilbene 9.05 µM 0.99388881578726 0.161408773288341 no 558 0.160138499963526 820 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3329 9141233 27.5565 µM 0.99348730442567 0.161508354290111 no 559 0.160236267180605 791 4909101 YNL103W MET4
SGTC_413 propylparaben 100 µM 0.992340559880819 0.161792985127437 no 560 0.160515711988022 789 7175 A pharmaceutical preservative.
SGTC_1274 0865-0114 173 µM 0.992300903427844 0.161802834008594 no 561 0.160525381375189 800 870624
SGTC_885 0865-0106 16.8 µM 0.991737613438702 0.161942772117799 no 562 0.160662768811383 796 2793380
SGTC_577 r071-0003 38.6 µM 0.991504511125984 0.16200070477342 no 563 0.160719645340856 933 4568517 YMR134W ERG29
SGTC_2467 5474540 200 µM 0.991262275716279 0.162060921568628 no 564 0.160778764258641 809 5413519
SGTC_3123 9126162 49.47 µM 0.9891705194146 0.162581513269313 no 565 0.161289859795875 792 25239884
SGTC_2956 9076196 2.52 µM 0.988147198790706 0.162836590955289 no 566 0.161540281528767 819 16423868
SGTC_1911 st060208 74.3 µM 0.988052635132993 0.162860175463473 no 567 0.161563435446023 834 688783
SGTC_913 3487-1245 167 µM 0.984683232776341 0.163701965665327 no 568 0.162389845652947 776 4016153
SGTC_3212 9128307 49.47 µM 0.981770273108611 0.16443199353599 no 569 0.16310651813179 698 27243542
SGTC_458 nppb 133 µM 0.979252573898584 0.165064661269883 no 570 0.163727598743082 805 4549 A chloride channel blocker.
SGTC_1637 st007924 17.4 µM 0.972650766819399 0.166731089902726 no 571 0.165363451055454 801 683336
SGTC_1021 4476-0760 85.3 µM 0.972504351695758 0.16676817064399 no 572 0.165399850510822 779 746768
SGTC_405 ebelactone b 50 µM 0.971987025417381 0.166899230058935 no 573 0.16552850165103 838 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3013 9080133 71.4286 µM 0.970760745970243 0.167210160946537 no 574 0.165833717087066 887 17050193
SGTC_1569 carminic acid 40.6 µM 0.970582956872902 0.167255271466936 no 575 0.165877998169226 857 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_701 4424-0219 185 µM 0.970126731388601 0.167371065685621 no 576 0.165991663038419 909 2911779
SGTC_2441 5730946 39.09 µM 0.969649074043528 0.167492354851982 no 577 0.166110721401439 849 1774275
SGTC_1390 3413-2614 145 µM 0.969499155914339 0.167530434493575 no 578 0.166148100579917 848 3421432
SGTC_1374 2889-5571 141 µM 0.967459271311272 0.168049125286992 no 579 0.166657246156408 847 2853281
SGTC_2231 micatex 6.853 µM 0.965824193565964 0.168465629361612 no 580 0.167066080061233 841 20737 An antifungal of unknown mechanism.
SGTC_1693 xanthone 101.9 µM 0.964618601920203 0.168773155016157 no 581 0.167367939358913 866 7020 An insecticide.
SGTC_2703 st077852 53.4 µM 0.962409981406906 0.169337471190551 no 582 0.167921850874372 798 6281836
SGTC_2179 6298986 200 µM 0.960727578535794 0.169768147206543 no 583 0.168344580389148 822 738374
SGTC_3196 9111891 49.47 µM 0.959802976997061 0.170005133529567 no 584 0.168577191879375 840 18891510
SGTC_1113 artemisinin 1.17947 µM 0.959317557665795 0.170129637099513 no 585 0.168699396472213 886 2240 An anti-malaria and mitochondrial poison.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.957436652687426 0.170612615768863 no 586 0.169173452932149 906 91467 include heat shock
SGTC_2389 9091542 195.52 µM 0.954292147912605 0.171422019884261 no 587 0.169967890774349 859 3626624 YOL127W RPL25
SGTC_806 3966-4455 5.86 µM 0.953944828261753 0.171511571180555 no 588 0.170055785162722 752 714982
SGTC_1498 4478-3555 97.6 µM 0.953613040125886 0.171597145817247 no 589 0.170139776272642 831 3437919
SGTC_2155 5570423 76 µM 0.951085590284592 0.17224991965285 no 590 0.170780464490159 797 797402
SGTC_2979 9012552 45.46 µM 0.950257711736379 0.1724640829639 no 591 0.170990660322841 813 17100905
SGTC_396 dithiazanine 1.25 µM 0.949254356804444 0.172723867669967 no 592 0.171245630808528 808 10578 An antihelmenthic.
SGTC_1908 st060353 56.5 µM 0.945772533421959 0.173627301163561 no 593 0.172132308854528 917 4227716
SGTC_1206 3978-0017 132 µM 0.944599788400705 0.173932270604364 no 594 0.172431617551797 807 3873677
SGTC_3033 9090887 49.47 µM 0.944595712008899 0.173933331253657 no 595 0.172432658509594 884 19325384
SGTC_2465 5809242 33.21 µM 0.944375629163539 0.173990601411197 no 596 0.17248886537563 877 2731748
SGTC_3267 9137951 49.47 µM 0.943789731363155 0.174143122703808 no 597 0.172638554521653 846 16643986
SGTC_2950 9072895 21.46 µM 0.942960230750437 0.174359204114576 no 598 0.172850622554848 865 17332245
SGTC_506 n9-isopropylolomoucine 153 µM 0.94170673341546 0.174686057928522 no 599 0.173171403364933 877 6610355
SGTC_547 1120-0019 610 nM 0.941436729283091 0.174756513338792 no 600 0.173240549355017 846 3676939
SGTC_305 1682-2595 20.8 µM 0.940815235265081 0.17491875574881 no 601 0.17339977601053 890 226033
SGTC_1118 chelidonine 707.474 nM 0.936801817809728 0.17596876789435 no 602 0.174430255042853 926 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2733 amorolfine 100 µM 0.934472908185066 0.176579896022116 no 603 0.175030002262527 825 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2769 toremifene 3.73 µM 0.934418813811203 0.176594106834263 no 604 0.175043948323746 849 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1717 st033143 58.0435 µM 0.933929517672008 0.176722679776834 no 605 0.175170125702814 888 674616
SGTC_3099 9120367 49.47 µM 0.932637272240317 0.17706252914686 no 606 0.175503641135459 879 24824940
SGTC_951 1171-0579 82.7 µM 0.931360461035523 0.177398724694255 no 607 0.175833568168002 920 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2522 biochanin a 4.94 µM 0.931173731246066 0.17744792603734 no 608 0.175881851908104 857 5280373 A possible chelator.
SGTC_688 0527-0193 473 µM 0.930532198297806 0.177617028876512 no 609 0.176047800555508 853 4007154
SGTC_1981 st071826 47 µM 0.930498174991484 0.177625999980585 no 610 0.176056604307385 818 11838600
SGTC_2726 cimetidine 79.27 µM 0.930153576437023 0.177716878206611 no 611 0.176145787132534 858 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1865 st057639 52.2 µM 0.929294601611822 0.177943536450561 no 612 0.176368216062839 896 688818
SGTC_1778 st046819 58.9 µM 0.923557782078887 0.17946198573417 no 613 0.177858301556184 944 671715
SGTC_753 1322-0200 289 µM 0.923301501765498 0.179530008780415 no 614 0.17792505274681 903 5403907
SGTC_4 0960-0234 25.671 µM 0.922315249422464 0.179791935364623 no 615 0.178182081011864 849 6821112
SGTC_1960 st011366 51.8 µM 0.922099789519208 0.179849188634878 no 616 0.178238263378148 906 3972846
SGTC_24 0417-1663 219 µM 0.918136903027216 0.180904271714006 no 617 0.179273598488792 876 4329390
SGTC_1685 st024049 53.0905 µM 0.917994204704458 0.180942336082733 no 618 0.179310949950897 871 1941139
SGTC_1936 st074407 74.3 µM 0.917433677748702 0.181091903616806 no 619 0.179457715932953 922 809813
SGTC_3288 9119690 36.221 µM 0.917188906934977 0.181157241030601 no 620 0.17952182935802 810 17595618 YKL019W RAM2
SGTC_1623 st003709 20.3 µM 0.914066779713201 0.181991934882235 no 621 0.180340878494495 918 16192618
SGTC_371 0195-0006 7.36 µM 0.912742055945072 0.182346822360513 no 622 0.18068910978233 790 3928593
SGTC_769 0302-0231 76 µM 0.910662766896311 0.182904725760015 no 623 0.181236543890284 963 571869 YER009W NTF2
SGTC_236 1509-0011 5.31 µM 0.910345477700965 0.182989952636406 no 624 0.181320170873509 1070 3107280
SGTC_993 3909-8757 62.7 µM 0.908242524937074 0.183555451823875 no 625 0.18187505058745 828 4288324 YLR208W SEC13
SGTC_218 alverine citrate 93.75 µM 0.907938511768091 0.18363729317406 no 626 0.181955354495738 867 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_50 0929-0078 56.389 µM 0.906226810366052 0.184098513153326 no 627 0.182407907591497 848 1377751
SGTC_2756 carbadox 75.1 µM 0.904650908612337 0.18452377872234 no 628 0.182825178058501 868 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1653 st012112 65 µM 0.904522815074637 0.184558372281386 no 629 0.182859121088524 869 720429
SGTC_2734 clemastine 41.6 µM 0.902369100761614 0.185140618638707 no 630 0.183430414738055 813 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_3037 9091026 49.47 µM 0.901968401464492 0.18524907152482 no 631 0.183536826753892 989 25236398 YIL048W NEO1
SGTC_1709 st033179 39.1045 µM 0.901868492546442 0.185276118919852 no 632 0.183563365133587 915 573381
SGTC_2622 2-methoxyxanthone 59.94 µM 0.901168909329054 0.185465579152437 no 633 0.18374925943364 958 71034 A hepatoprotective.
SGTC_235 0330-0087 5 mM 0.900162782171558 0.185738267973581 no 634 0.184016814584829 945 46494818 YHR062C RPP1
SGTC_887 0885-0007 9.62 µM 0.898743070463876 0.186123472700179 no 635 0.184394764910967 922 5719458
SGTC_3334 9142812 21.919 µM 0.894525517680017 0.187270722029185 no 636 0.185520391494373 875 45283678
SGTC_2335 9018011 154.17 µM 0.894462703422951 0.18728784160211 no 637 0.185537188215241 954 6458208
SGTC_1852 st056254 31.4 µM 0.894394415850269 0.187306453985465 no 638 0.185555449587815 900 442583
SGTC_2181 6316240 54.2555 µM 0.893940424710797 0.187430222367121 no 639 0.185676883655002 864 12779990
SGTC_1775 st081588 35.1725 µM 0.892452342637632 0.187836261895093 no 640 0.186075263099325 951 1426443 YGL099W LSG1
SGTC_3343 9148379 18.9835 µM 0.891748775938461 0.188028426778607 no 641 0.186263801639129 947 1955036
SGTC_782 0083-0095 30.5 µM 0.890000834611098 0.188506366293543 no 642 0.186732718963037 963 3591729 An indicator and reagent.
SGTC_573 3702-0553 84.7 µM 0.889708653657451 0.188586330334827 no 643 0.186811173087156 887 1222756
SGTC_2874 9043904 71.43 µM 0.889543937004186 0.188631419181789 no 644 0.186855410493948 827 4463428
SGTC_2405 ticlatone 3.52 µM 0.885975370120953 0.189609894803267 no 645 0.187815399770394 966 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1906 st060206 94.7 µM 0.885672070090326 0.189693201235273 no 646 0.187897131488259 979 5133468
SGTC_118 0083-0097 135.343 µM 0.884446136662773 0.190030153721359 no 647 0.188227713396371 1079 5207356
SGTC_1999 st074831 12.5 µM 0.884099293262015 0.190125551677746 no 648 0.188321307345181 928 17112523
SGTC_1123 mangostin 811.285 nM 0.883614009042299 0.190259076637375 no 649 0.188452307029587 870 5281650 An antioxidant.
SGTC_376 3970-0862 59.1 µM 0.883262374450743 0.190355864160524 no 650 0.188547263871297 944 3135186
SGTC_1184 1269-1718 139 µM 0.88315422368115 0.190385638771069 no 651 0.188576475278343 952 5403821
SGTC_1115 galangin 695.678 nM 0.882569155990949 0.19054676129752 no 652 0.188734549808592 1012 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3330 9141424 71.43 µM 0.880997521540313 0.190979989992805 no 653 0.189159580730549 979 27261020
SGTC_1367 1812-0510 76.9 µM 0.880487115380695 0.191120815800292 no 654 0.18929774105038 916 1142582 YDR527W RBA50
SGTC_1455 4262-0120 131 µM 0.878064182492498 0.191790193689226 no 655 0.189954444535704 967 1529587
SGTC_1864 st057645 30.4 µM 0.876444961562695 0.192238331154791 no 656 0.190394092380875 950 688666
SGTC_1740 st038286 13.222 µM 0.876037867463538 0.192351099669114 no 657 0.19050472404227 921 716786
SGTC_653 0203-0016 55.2 µM 0.874782778037851 0.192699024611644 no 658 0.190846054789158 957 295302
SGTC_2201 6605497 169.863 µM 0.871450267612817 0.193624698524094 no 659 0.191754174587086 953 670741
SGTC_690 glyoxal 20.3 µM 0.8712442848913 0.193682003344851 no 660 0.191810392234447 907 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_976 1348-1067 47.6 µM 0.869624559948413 0.194132974467972 no 661 0.192252805760458 1041 5310671 YGL099W LSG1
SGTC_2437 5741531 144.16 µM 0.866419240508306 0.19502729727845 no 662 0.1931301482019 997 2262990
SGTC_1166 k206-0078 225 µM 0.863979917117789 0.195709573414479 no 663 0.193799461480695 969 5404595
SGTC_2092 5303694 80.6725 µM 0.861419574568124 0.196427254805809 no 664 0.194503499463947 940 1963699
SGTC_560 2332-1943 155 µM 0.861136353936958 0.196506741331292 no 665 0.194581474428618 946 21177716
SGTC_2855 9016525 58.44 µM 0.860441882149397 0.196701728918731 no 666 0.194772753610759 992 43811474
SGTC_1182 1222-0449 220 µM 0.859934140504219 0.196844362217176 no 667 0.19491267384465 930 658318
SGTC_1317 1273-0028 910 nM 0.859589073467756 0.196941333173221 no 668 0.195007800114162 979 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_905 2-aminofluorene 215 µM 0.858574686242744 0.197226564325995 no 669 0.195287604463729 1036 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2328 6201408 200 µM 0.857569912105329 0.19750933865437 no 670 0.195564997520178 893 2890418
SGTC_1190 1486-1332 13 µM 0.852432794040681 0.198958908028987 no 671 0.19698696256385 966 4150046
SGTC_597 k018-0003 82.8 µM 0.850942833190219 0.199380535088395 no 672 0.197400554778319 1067 6786234
SGTC_1664 st014217 9.02 µM 0.850886189370535 0.199396574685372 no 673 0.197416288662252 1071 3982782
SGTC_2170 morpholine 200 µM 0.849892315466131 0.199678132243252 no 674 0.19769247916555 965 121171 Reacts with secondary amines.
SGTC_1975 st070967 30.8 µM 0.847814954586859 0.200267406108866 no 675 0.198270516655881 1049 261391
SGTC_765 1319-0117 244 µM 0.846477918249386 0.200647228169044 no 676 0.198643093630034 984 3487746 YGL099W LSG1
SGTC_2 0422-0095 29 µM 0.844726384772913 0.201145453420481 no 677 0.199131812241189 876 6790840
SGTC_3286 9117135 37.221 µM 0.84406119504622 0.201334861440058 no 678 0.199317605274222 948 3438150
SGTC_1481 3346-2004 36 µM 0.842974105186064 0.201644632538668 no 679 0.199621463123596 1015 2770522
SGTC_1222 0366-0074 1.18 µM 0.842698578124194 0.201723190528744 no 680 0.199698521307255 1033 286520
SGTC_97 0535-0701 19.132 µM 0.841726535020055 0.202000484816021 no 681 0.199970520910987 919 2832013 YGL099W LSG1
SGTC_1226 3909-7979 35.4 µM 0.841483168489907 0.202069945567477 no 682 0.200038655211453 1009 6615510
SGTC_2553 4-methylesculetin 85.09 µM 0.839626251245327 0.202600410292875 no 683 0.200558987857408 1022 5319502
SGTC_1225 1216-0074 20.6 µM 0.838366567362993 0.202960737005451 no 684 0.200912430084641 978 4241466
SGTC_2683 piperine 63.03 µM 0.837400066420539 0.203237459404506 no 685 0.201183864216749 959 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3120 9124077 49.47 µM 0.836224842282548 0.203574245308628 no 686 0.201514212688327 1050 18774327 YGL155W CDC43
SGTC_2380 9035439 200 µM 0.834291714468924 0.204128948381485 no 687 0.202058309842336 1050 6462575
SGTC_2612 dictamnine 15.46 µM 0.832825110133317 0.204550384437558 no 688 0.202471685456888 941 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_293 4049-0273 38.5 µM 0.831443652862996 0.204947826205078 no 689 0.202861523680523 945 1380311
SGTC_2962 9082311 13.18 µM 0.831177121843625 0.205024559305945 no 690 0.202936788560003 967 16459453
SGTC_707 0865-0008 204 µM 0.830813125462638 0.205129379834463 no 691 0.203039603322068 1046 723043
SGTC_1299 1079-1439 3.74 µM 0.830620460587064 0.205184874685697 no 692 0.203094036211419 981 323161
SGTC_2387 9077560 195.08 µM 0.830036917144589 0.205353011929966 no 693 0.203258955714891 963 5303272
SGTC_450 aminopyrene 156 nM 0.830023570013805 0.205356858615769 no 694 0.2032627287804 986 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_468 gf-109203x 121 µM 0.829896257598383 0.205393552612377 no 695 0.20329872049518 909 2396 A protein kinase C inhibitor.
SGTC_682 0kpi-0099 17 µM 0.829491137945531 0.20551034214552 no 696 0.203413274699507 1005 1714895 YML126C ERG13
SGTC_310 1273-0058 1.06 µM 0.829246692053948 0.205580831066225 no 697 0.203482414396332 1074 2734232
SGTC_932 2857-0803 154 µM 0.829058559560718 0.205635091112217 no 698 0.203535635813503 1054 674898
SGTC_930 2810-3379 265 µM 0.829011353505452 0.205648707333708 no 699 0.203548991391981 1052 1015764
SGTC_3319 9138450 16.7555 µM 0.827482220312537 0.206090063346208 no 700 0.203981897723192 955 2029690
SGTC_69 0096-0274 206.684 µM 0.825391486015873 0.206694423237455 no 701 0.204574683508204 1103 6741392
SGTC_543 3844-1095 191 µM 0.824941751827569 0.20682456305137 no 702 0.204702330452492 1005 4230703
SGTC_747 3448-8087 38.7 µM 0.824283381666127 0.207015163415913 no 703 0.204889279451473 999 5168703
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.823507409757044 0.207239943263617 no 704 0.205109752612128 1063 16623 A steroid.
SGTC_2803 7707263 71.43 µM 0.822474626494658 0.20753933879365 no 705 0.205403410950694 960 2199229
SGTC_2241 6772625 37.8075 µM 0.821543459013593 0.207809495731768 no 706 0.20566839010946 1012 2285411
SGTC_2171 5739187 198.077 µM 0.82091080729971 0.207993163586898 no 707 0.205848537349176 981 2262761
SGTC_1647 st011722 22.4 µM 0.820351164647265 0.208155715720063 no 708 0.206007973305584 980 2854783
SGTC_167 3672-0051 66.205 µM 0.819260157510033 0.208472821844763 no 709 0.206318999556682 975 3237971
SGTC_3320 9137005 35.139 µM 0.816259161858807 0.209346542890112 no 710 0.207175963040448 940 4908713
SGTC_689 0833-0039 98 µM 0.815665116295632 0.209519750685513 no 711 0.207345847809443 1032 5374726
SGTC_65 0798-0905 34.986 µM 0.814599045108748 0.209830799835719 no 712 0.207650928615176 1060 3602145
SGTC_2321 7390090 138.78 µM 0.813541864057726 0.210139522998605 no 713 0.207953727051473 952 649046
SGTC_2314 7727897 200 µM 0.812905156955645 0.210325585978034 no 714 0.208136218800927 1033 900724
SGTC_2821 7996764 71.43 µM 0.811435788630198 0.21075534403343 no 715 0.208557726850446 1084 2987135
SGTC_1413 3910-0535 34.4 µM 0.809850905702911 0.211219464491763 no 716 0.209012935522371 1050 2876951
SGTC_2842 9000675 19.48 µM 0.809016771288521 0.211463974514922 no 717 0.209252749719541 989 2989072
SGTC_2961 9083290 32.55 µM 0.807858271921589 0.21180384053316 no 718 0.209586087600024 985 17741490
SGTC_2938 9059746 27.26 µM 0.807648885792835 0.211865301696092 no 719 0.209646368095754 967 6471769
SGTC_1279 0874-0590 65.2 µM 0.80572186314603 0.21243143083791 no 720 0.210201620163508 1026 3523074
SGTC_2990 9074105 71.4286 µM 0.803352152289528 0.213128825158625 no 721 0.210885611130295 1022 6502001
SGTC_2144 5628481 200 µM 0.802027692984848 0.213519188139337 no 722 0.211268469629844 1027 2818399
SGTC_845 0330-0138 4.51 µM 0.801653372913728 0.213629588404491 no 723 0.211376747260312 1039 9039800
SGTC_2240 6690706 185.951 µM 0.801518366916826 0.213669414620173 no 724 0.211415807720699 928 805876
SGTC_1619 st003326 88.7 µM 0.798570848450449 0.214539997960911 no 725 0.212269648339089 1031 2849032
SGTC_120 rhodamine 6G 52.259 µM 0.798333224604471 0.21461027259426 no 726 0.212338571176672 1138 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1152 3909-8331 15.9 µM 0.796032494460438 0.215291379770893 no 727 0.213006574358074 1010 16001939
SGTC_1247 0448-0043 5.84 µM 0.794452866539178 0.215759737541521 no 728 0.213465918904166 1061 3089013 YGL099W LSG1
SGTC_1496 4469-0713 57.4 µM 0.794383998113861 0.215780170373305 no 729 0.213485958476766 1038 746691
SGTC_1659 st012954 42.1 µM 0.79372678903686 0.2159752166172 no 730 0.213677250594864 1006 24207262
SGTC_1088 bifonazole 369 nM 0.792207747009983 0.21642642797515 no 731 0.214119776080171 1007 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_754 3474-0146 171 µM 0.791075385355922 0.216763135661157 no 732 0.21445000098507 990 24762078
SGTC_2849 9019321 12.99 µM 0.789926388337714 0.21710509928829 no 733 0.214785379672233 999 16489627
SGTC_3153 9100258 49.47 µM 0.789774661522362 0.21715027939516 no 734 0.214829689707316 991 25236848
SGTC_876 0720-0963 56.8 µM 0.789506985319957 0.217229999309522 no 735 0.214907874346684 1071 765861
SGTC_2409 alverine citrate 63.97 µM 0.788175028258434 0.217626936945915 no 736 0.215297166845625 1045 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1895 st058434 18.3 µM 0.788011998244578 0.217675550389969 no 737 0.215344843892834 1085 5393175
SGTC_1341 1486-1360 280 µM 0.786950854532499 0.217992122814452 no 738 0.215655318006981 1075 3976547
SGTC_957 1187-1561 14.1 µM 0.786345277109103 0.218172904440894 no 739 0.215832616780045 1075 1538454
SGTC_2265 7929201 200 µM 0.785992428189319 0.218278279437322 no 740 0.21593596155297 1106 1265108
SGTC_1716 st033144 30.6155 µM 0.784150917105721 0.218828704971073 no 741 0.216475780824746 1085 674617
SGTC_1112 tnp00069 1.16933 µM 0.784128775228513 0.218835328007862 no 742 0.216482276226664 1099 145826
SGTC_802 4112-3352 742 µM 0.783360681261747 0.219065150220258 no 743 0.216707669247127 1096 704594
SGTC_103 0844-0104 51.839 µM 0.778538213026497 0.220511253723921 no 744 0.218125894046524 1138 5375804
SGTC_2182 6325192 200 µM 0.778453675126789 0.220536652618714 no 745 0.218150803152795 1038 736248
SGTC_1724 st037281 8.293 µM 0.77744400493157 0.220840131391966 no 746 0.21844842933243 1073 574124 YDL195W SEC31
SGTC_2783 7738165 71.43 µM 0.776445828526537 0.221140390360503 no 747 0.218742897164384 997 17201110
SGTC_2154 5570129 200 µM 0.77451616874418 0.221721508264531 no 748 0.219312805197907 1108 673366
SGTC_2506 ethyl hematommate 54.16 µM 0.774343595138361 0.221773521351292 no 749 0.219363814830596 1015 3940691 An allergen.
SGTC_362 0310-0100 9.03 µM 0.772911128019151 0.222205530945995 no 750 0.219787489249395 1050 790235
SGTC_2122 5258151 111.688 µM 0.772477706408477 0.2223363386722 no 751 0.219915772932186 1047 2173356
SGTC_2987 9018338 71.43 µM 0.77169811761167 0.222571731053323 no 752 0.220146622939752 1089 5055682
SGTC_2563 tomatine 8.54 µM 0.771319960671573 0.222685964538281 no 753 0.220258651927898 1086 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3121 9125696 49.47 µM 0.771118495414328 0.222746836717768 no 754 0.220318349351466 1136 1235365
SGTC_1777 st045864 34.765 µM 0.770917045907778 0.222807713618906 no 755 0.22037805138169 1079 4691462
SGTC_2471 5466956 24.79 µM 0.768514425532505 0.223534502321598 no 756 0.221090811879031 1056 724419
SGTC_2112 5488546 200 µM 0.76809543026614 0.223661385640876 no 757 0.221215245804398 1086 600757
SGTC_2801 7907800 81.82 µM 0.763550295075802 0.225040406816527 no 758 0.22256763966796 1109 6620925
SGTC_1267 0828-0272 9.49 µM 0.763266825866259 0.225126572392883 no 759 0.222652141115026 1110 745334
SGTC_615 k087-0205 167 µM 0.761204352920624 0.225754060678437 no 760 0.223267509351132 1079 9642773
SGTC_320 4092-0846 5.34 µM 0.759973696658192 0.226128947233183 no 761 0.223635153859221 1102 1359356
SGTC_541 4513-1321 94 µM 0.759310690603791 0.22633106005193 no 762 0.223833361951486 1040 747515
SGTC_132 0417-1715 25.805 µM 0.757003143432854 0.227035294894008 no 763 0.224523989604149 1121 6769098
SGTC_1256 0570-0116 285 µM 0.756696725194103 0.227128902785982 no 764 0.224615788614368 1099 410638
SGTC_1444 4112-3581 28 µM 0.756494992291502 0.227190542166727 no 765 0.224676236849275 1101 2877249
SGTC_2012 4023501 200 µM 0.753612866983693 0.228072202931764 no 766 0.225540857930656 1068 3477460
SGTC_2644 guaiazulene 100 µM 0.753447427864478 0.22812287015644 no 767 0.225590545803302 1123 3515 A coloring agent.
SGTC_2211 7117706 200 µM 0.752924898522981 0.228282941045551 no 768 0.225747522584177 1071 822771
SGTC_3148 9097893 49.47 µM 0.752462906272303 0.228424519658973 no 769 0.225886364435497 1070 17174100
SGTC_1104 tacrolimus 29.8 µM 0.752342694660138 0.228461366877938 no 770 0.225922499369702 1130 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1690 st023502 41.2 µM 0.750552571635203 0.22901046969566 no 771 0.226460986857735 1090 24207482
SGTC_2411 st077133 39.94 µM 0.75029205513787 0.229090442270255 no 772 0.226539413275354 1134 1403142 YNL221C POP1
SGTC_3248 9135562 49.47 µM 0.746760070031188 0.230176225123976 no 773 0.22760420122509 1141 17650701
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.746429512061305 0.230277990489493 no 774 0.22770399857393 1137 115019
SGTC_2931 9014674 55.67 µM 0.745026750949089 0.230710123462892 no 775 0.228127774145888 1127 2996810
SGTC_2076 5212012 200 µM 0.743885853444659 0.231061920830717 no 776 0.22847276722832 1029 604802
SGTC_2816 7982706 58.44 µM 0.743423154683356 0.231204679941027 no 777 0.228612765023099 1104 2981853
SGTC_3274 9138298 49.47 µM 0.742984292457994 0.231340130088625 no 778 0.228745595154211 1124 17015756
SGTC_1772 st048439 82.2 µM 0.739641362583055 0.232373341027152 no 779 0.229758818350993 1113 2927068 YDL195W SEC31
SGTC_2244 6635614 200 µM 0.739588494006543 0.23238970189398 no 780 0.229774862680594 986 836499
SGTC_2290 7904846 200 µM 0.739515525149772 0.232412284105708 no 781 0.229797007987801 1140 2962154
SGTC_1968 st069590 43.6 µM 0.738697344058519 0.232665576210584 no 782 0.2300453994525 1093 6384066
SGTC_593 1203-0218 61.7 µM 0.736520685725219 0.233340171544115 no 783 0.230706941769285 1176 3666956
SGTC_1953 st076800 12.1 µM 0.735446701837452 0.23367342272645 no 784 0.231033744173203 1067 297591
SGTC_2070 5230947 200 µM 0.735207482464463 0.233747687072935 no 785 0.231106571373002 1216 2835538
SGTC_2998 9066762 71.4286 µM 0.734388039331218 0.234002177848575 no 786 0.231356137166787 1146 4945196
SGTC_312 4092-0653 6.84 µM 0.732909160978598 0.234461854656365 no 787 0.231806917655627 1158 1148278
SGTC_717 1532-0246 73.2 µM 0.731648772621859 0.234854012662496 no 788 0.232191485555337 1129 9561992
SGTC_587 k089-0003 57 µM 0.731036968511343 0.235044500387375 no 789 0.23237828628143 1085 9659696
SGTC_2300 7976697 71.57 µM 0.730971702013878 0.235064826416752 no 790 0.232398218882711 1045 2236109
SGTC_3088 9117578 49.47 µM 0.729958385563846 0.235380529398516 no 791 0.232707811006422 1199 678341
SGTC_865 0488-0499 301 µM 0.728014570660962 0.235986787586254 no 792 0.233302333479054 1177 9634651
SGTC_1319 1306-0155 43.7 µM 0.72800991924274 0.235988239352588 no 793 0.233303757141473 1177 3122360
SGTC_1235 benzylparaben 21.5 µM 0.727787532023999 0.23605765495287 no 794 0.233371828958422 1115 7180
SGTC_2280 7785178 200 µM 0.726943112797638 0.236321333086607 no 795 0.233630402560671 1127 2954328
SGTC_319 1348-1596 45.5 µM 0.724835358158574 0.236980207041857 no 796 0.234276520655163 1168 5380505
SGTC_452 diindolylmethane 8 µM 0.724651520073976 0.237037721776038 no 797 0.234332921849533 1075 3071 Inhibits expression of several cancer promoting factors.
SGTC_2636 apigenin dimethyl ether 100 µM 0.724589299795849 0.237057189462309 no 798 0.23435201262119 1152 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2922 7999257 32.47 µM 0.723300151107011 0.237460740193907 no 799 0.234747749997243 1128 2988377
SGTC_1196 1588-0294 184 µM 0.722914258949863 0.237581611863262 no 800 0.234866281336706 1113 6144269
SGTC_512 prima-1 270 µM 0.722828417852796 0.237608504164028 no 801 0.234892652941605 1155 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1157 4092-0394 27.6 µM 0.722590818610228 0.237682947969378 no 802 0.23496565533809 1207 3659885
SGTC_2653 dihydrofissinolide 100 µM 0.722461734275639 0.237723397608033 no 803 0.235005321770692 1168 6857746
SGTC_2007 4011539 71.82 µM 0.722034201202293 0.237857395577312 no 804 0.235136725179724 1145 45595301
SGTC_378 3970-0959 8.33 µM 0.72128407946174 0.238092599760262 no 805 0.23536737508798 1133 6615653
SGTC_1286 0929-0070 131 µM 0.720847199875161 0.238229644113771 no 806 0.235501765790251 1189 1420408
SGTC_79 0052-0007 94.094 µM 0.720097364994547 0.238464959827734 no 807 0.235732524893605 1179 2801472
SGTC_1219 1469-0211 33.1 µM 0.719823113620718 0.23855105809372 no 808 0.235816955941562 1132 6822282
SGTC_1376 2910-0861 41.3 µM 0.718382582085328 0.239003576755585 no 809 0.236260711744793 1162 1112859
SGTC_1843 st055809 45.5 µM 0.717616883361826 0.239244298974707 no 810 0.236496772315559 1134 16413835
SGTC_840 0245-0196 390 µM 0.717256115659386 0.239357763893328 no 811 0.236608039921749 1212 3827528
SGTC_1073 triclabendazole 3.09 µM 0.717132849534264 0.239396539013484 no 812 0.236646064134731 1208 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2603 homopterocarpin 100 µM 0.717039606123563 0.239425872338917 no 813 0.236674829398235 1168 101795 A weak amylase inhibitor.
SGTC_73 0327-0325 16.231 µM 0.714783588924089 0.24013618782987 no 814 0.237371388672164 1205 53298
SGTC_2432 5630864 12.22 µM 0.710872958238942 0.241370181128098 no 815 0.238581482307389 1141 5714970
SGTC_1188 1403-0014 4.57 µM 0.709758151396519 0.241722586637596 no 816 0.238927062174665 1210 9614867
SGTC_899 1083-0020 478 µM 0.707382596723582 0.242474462264495 no 817 0.239664374511951 1191 767123
SGTC_3092 9117248 49.47 µM 0.705183798078337 0.243171521064232 no 818 0.240347931348747 1231 17141857
SGTC_2879 9041815 71.43 µM 0.70516999035265 0.243175901782644 no 819 0.240352227211928 1128 4942971
SGTC_219 mitoxanthrone 164.414 µM 0.704126130988349 0.243507206114187 no 820 0.240677114088639 1149 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3179 9107801 49.47 µM 0.703746413800962 0.243627782749781 no 821 0.240795355105588 1194 4818259
SGTC_3340 9146634 11.102 µM 0.702831563845841 0.243918419557091 no 822 0.241080362127036 1182 4907387
SGTC_866 0495-0101 262 µM 0.701526854785959 0.244333233345432 no 823 0.241487140688406 1162 635694
SGTC_1124 fisetin 1.16336 µM 0.700947859050148 0.244517438578131 no 824 0.241667777718118 1153 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.699748682626208 0.244899189681746 no 825 0.242042133963873 1208 688788
SGTC_1618 st003135 44.5 µM 0.699074893476009 0.245113827339919 no 826 0.242252613884776 1158 1270615
SGTC_2251 lansoprazole 556 µM 0.697905210724726 0.245486673606331 no 827 0.242618237744557 1058 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2988 9073640 71.4286 µM 0.697469190282049 0.24562573673342 no 828 0.242754607075952 1214 9102229
SGTC_1866 st057638 64 µM 0.696358028590053 0.24598031871404 no 829 0.243102320437698 1175 688802
SGTC_1454 4239-0054 42.6 µM 0.696050578596242 0.246078477339974 no 830 0.243198577630508 1264 1340767
SGTC_2511 berberine 10.47 µM 0.694796678156064 0.246479023821979 no 831 0.243591365127599 1201 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2925 9010536 32.5 µM 0.694072992196013 0.246710357265012 no 832 0.243818217423488 1192 2994177
SGTC_1032 k061-1018 98.7 µM 0.6939116846483 0.246761936674231 no 833 0.243868797692531 1266 4005393
SGTC_2945 9067681 61.76 µM 0.693813804919673 0.246793237333302 no 834 0.243899492029633 1274 16456930
SGTC_687 k029-0044 34.9 µM 0.693630626423353 0.246851821135202 no 835 0.243956941011209 1220 5829338
SGTC_2470 5664817 21.68 µM 0.69349411823845 0.246895483766117 no 836 0.243999757858769 1233 2859561
SGTC_2512 diallyl trisulfide 49.23 µM 0.693117647843246 0.247015920583266 no 837 0.244117861712358 1212 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1652 st011932 78 µM 0.692218009289748 0.247303851626474 no 838 0.244400215306189 1167 1551076
SGTC_1826 st055655 41.6 µM 0.692090671308522 0.247344620882279 no 839 0.24444019483215 1209 676168
SGTC_2718 lomofungin 53.02 µM 0.691685811234345 0.247474267063978 no 840 0.244567329678516 1227 5351222 A RNA synthesis inhibitor.
SGTC_2003 4023581 200 µM 0.691493837492462 0.247535754480099 no 841 0.244627626043822 1216 16641307
SGTC_1883 5-benzylidenerhodanine 20 µM 0.690417461787231 0.247880658801246 no 842 0.244965849379894 1199 1273210
SGTC_715 0868-0130 184 µM 0.690302613506701 0.247917474908496 no 843 0.245001952342669 1232 2876258
SGTC_1249 0481-0015 10.2 µM 0.690257067933762 0.247932075941267 no 844 0.245016270547107 1178 4227577
SGTC_478 N-arachidonylglycine 10 µM 0.689952783127659 0.248029635558718 no 845 0.245111940395563 1143 5283389
SGTC_1784 st039334 36.3 µM 0.689818960802119 0.248072548078717 no 846 0.24515402168454 1246 3496984
SGTC_1714 st033236 13.627 µM 0.689761361511886 0.248091019539593 no 847 0.245172135346878 1234 2916566
SGTC_2134 5324836 1.464 µM 0.689008834357622 0.248332414143352 no 848 0.24540885407358 1162 699272
SGTC_626 0214-0009 33 µM 0.688349648370375 0.248543969733966 no 849 0.245616311808065 1222 3437874
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.687135206642444 0.248933977374243 no 850 0.245998765040676 1237 6708784 An antioxidant flavonoid
SGTC_824 1304-0008 100 µM 0.684356605120807 0.24982752532243 no 851 0.246875005546256 1223 768245
SGTC_3089 9117425 49.47 µM 0.684342089448381 0.249832197766679 no 852 0.246879587490314 1168 9401657
SGTC_2033 5192550 145 µM 0.683139540439558 0.250219446876533 no 853 0.247259336084919 1196 182073
SGTC_2810 7959871 45.46 µM 0.682366209732756 0.250468645649943 no 854 0.247503708288831 1219 2974535
SGTC_2347 9049783 174.81 µM 0.681280206970869 0.250818822057202 no 855 0.247847102482665 1217 6467988 YPL169C MEX67
SGTC_237 nikkomycin 200 µM 0.677497534142122 0.252040547681267 no 856 0.249045167038256 1264 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1568 digitonin 820 nM 0.677342197973174 0.252090785102066 no 857 0.249094431562325 1236 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1159 4092-0538 61.2 µM 0.676331475581119 0.252417792772533 no 858 0.249415106509916 1266 717301
SGTC_2075 5212009 200 µM 0.674490759476595 0.253013909264067 no 859 0.249999679274407 1158 780898
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.674060484304636 0.253153360749051 no 860 0.250136430389328 1322 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1097 itavastatin 7.23 µM 0.670303634301193 0.254372665039231 no 861 0.251332125411995 1257 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_548 1436-0017 110 µM 0.669337398773499 0.254686758469306 no 862 0.251640137585064 1286 9677137
SGTC_3202 9113761 49.47 µM 0.667709933793856 0.255216256014909 no 863 0.252159383873882 1279 4798415
SGTC_1343 1487-0095 224 µM 0.666960683408984 0.255460218815322 no 864 0.252398623690735 1238 4560101 YGL055W OLE1
SGTC_2372 9071633 200 µM 0.666471816337191 0.255619464085001 no 865 0.252554786138621 1264 21321366
SGTC_3204 9114183 49.47 µM 0.666102734151922 0.255739724543955 no 866 0.252672718522306 1259 17027248
SGTC_2450 5739737 12.93 µM 0.665601861332346 0.255902974437451 no 867 0.252832808182659 1240 2262825
SGTC_2043 5101342 149 µM 0.665260404231841 0.25601429699869 no 868 0.252941975771983 1237 678451
SGTC_1386 3228-0095 33.8 µM 0.664994466428672 0.256101016096921 no 869 0.25302701619185 1237 870181
SGTC_1628 st004252 77.7 µM 0.662770902128277 0.256826692614418 no 870 0.253738646090089 1240 692968
SGTC_402 epigallocatechin gallate 10 µM 0.662661756235047 0.256862340712138 no 871 0.253773604199032 1224 65064 An antioxidant.
SGTC_1796 st049173 110.4 µM 0.660019850891455 0.257725997246873 no 872 0.254620545280521 1207 94134
SGTC_2720 fluspirilene 36.88 µM 0.659258562557907 0.25797514698065 no 873 0.254864873305092 1238 3396 An atypical antipsychotic.
SGTC_629 3448-6466 76.7 µM 0.65877124608039 0.258134698462861 no 874 0.255021337140923 1251 573744
SGTC_2108 5365811 200 µM 0.658201054335082 0.258321448934849 no 875 0.255204473710005 1279 780283
SGTC_2750 bromebric acid 70.15 µM 0.656219370631269 0.258971038492428 no 876 0.255841493587503 1294 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_182 3448-4371 550.524 µM 0.655668594181423 0.259151731174712 no 877 0.256018690074914 1291 3491403
SGTC_1065 prochlorperazine maleate 2.48 µM 0.653264600892149 0.25994116924758 no 878 0.256792854719181 1295 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2517 totarol 10 µM 0.652347494975927 0.260242660633287 no 879 0.257088513655296 1221 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2873 9040596 71.43 µM 0.651484069256021 0.260526669670471 no 880 0.257367028741453 1255 6463863
SGTC_936 3005-4620 401 µM 0.649416778118613 0.26120731741757 no 881 0.258034511050893 1304 777207
SGTC_2765 myclobutanil 7.74 µM 0.648507102587631 0.261507113874192 no 882 0.258328509244578 1290 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2911 7942208 15.64 µM 0.648125795055438 0.261632831695464 no 883 0.258451795702648 1237 1243384
SGTC_3332 9141069 11.198 µM 0.647574038978804 0.261814801625707 no 884 0.258630246471853 1233 17332883
SGTC_275 trichlorophene 5.69 µM 0.646082019176505 0.262307196777242 no 885 0.259113119731215 1313 62616
SGTC_1502 4534-4282 27.7 µM 0.645823532316044 0.262392550578009 no 886 0.259196823067241 1270 3278949
SGTC_1426 4048-4480 71.7 µM 0.645652874389483 0.262448910569036 no 887 0.259252093255718 1272 14224343
SGTC_2051 5263410 176 µM 0.644983633675795 0.262669987934392 no 888 0.259468895893854 1320 227584
SGTC_51 1013-0126 23.419 µM 0.643748441628684 0.263078272058122 no 889 0.259869286015165 1377 1627850
SGTC_1388 3346-4487 254 µM 0.643010990972416 0.263322185749235 no 890 0.260108484073105 1327 3345614
SGTC_1122 capsaicin 818.572 nM 0.642867386401294 0.263369696758296 no 891 0.260155076571734 1333 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2866 9034245 58.44 µM 0.642523317402367 0.263483548440351 no 892 0.260266727246489 1263 6462273
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.641501136737634 0.263821933902082 no 893 0.260598571294006 1247 5355888
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.641041842654991 0.263974051980661 no 894 0.260747748903739 1280 688669
SGTC_2858 9025781 8.96 µM 0.639627110901711 0.264442891505422 no 895 0.261207526329328 1298 4894980 YPL153C RAD53
SGTC_3251 9135047 49.47 µM 0.639246908889174 0.264568961970827 no 896 0.261331160175246 1310 17682963
SGTC_40 0327-0103 19.753 µM 0.636113208059905 0.265609223205166 no 897 0.262351318642404 1251 409036
SGTC_1440 4100-1550 40 µM 0.634689480525625 0.266082527223229 no 898 0.262815477898485 1292 742806
SGTC_2897 9048598 12.99 µM 0.632812006879301 0.266707326953957 no 899 0.263428207494798 1274 6467404
SGTC_1167 k781-0610 148 µM 0.632560259470065 0.266791161692446 no 900 0.263510422829168 1319 4525169
SGTC_2822 7994718 71.43 µM 0.632192414108705 0.266913682304339 no 901 0.263630576820825 1287 1018011
SGTC_3035 9091303 49.47 µM 0.631714334397215 0.267072961843009 no 902 0.263786779815064 1312 25237002
SGTC_2208 7283366 200 µM 0.631284695135449 0.267216143640899 no 903 0.263927196113989 1298 898663
SGTC_1334 1486-0610 236 µM 0.630919856971192 0.267337760202146 no 904 0.264046463783608 1297 3742339
SGTC_2185 6113692 200 µM 0.630876163770932 0.267352326934287 no 905 0.26406074918032 1305 874150
SGTC_177 1327-0068 8.361 µM 0.630737769973247 0.26739846822931 no 906 0.264105999330062 1298 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_926 2268-1401 59.4 µM 0.630698320661776 0.267411621594274 no 907 0.264118898660866 1282 2931578
SGTC_93 0109-0045 59.227 µM 0.630656705749031 0.267425497377361 no 908 0.264132506458534 1343 88733
SGTC_308 4092-1169 104 µM 0.630280267707397 0.26755103072159 no 909 0.264255615401251 1268 2268590 YDL196W YDL196W
SGTC_1005 4092-0690 4.4 µM 0.629755826495848 0.26772596919968 no 910 0.264427175464248 1282 1529343
SGTC_2189 6047310 154.431 µM 0.629414261560862 0.267839936407795 no 911 0.264538941822722 1239 711535
SGTC_762 1165-0429 115 µM 0.627408898174097 0.268509542340729 no 912 0.265195618233793 1337 5967793
SGTC_220 paclitaxel 373.376 µM 0.627394950081185 0.268514202659314 no 913 0.26520018857411 1282 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_561 1550-0330 72.9 µM 0.626951763537835 0.268662300736669 no 914 0.265345427336385 1265 6812934
SGTC_733 4069-0007 56.1 µM 0.626904688711274 0.268678033975725 no 915 0.265360856822424 1340 5717425 YNL287W SEC21
SGTC_3168 9103419 49.47 µM 0.626574848722246 0.268788285313774 no 916 0.265468979636708 1254 16649256
SGTC_3305 9127027 53.8275 µM 0.626570100559986 0.268789872586329 no 917 0.265470536265706 1257 41905295
SGTC_1873 rapamycin 2 nM 0.62541495318744 0.269176168930183 no 918 0.265849375268929 1303 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3282 9108498 15.4605 µM 0.623292925822948 0.269886527571253 no 919 0.26654602284011 1280 16459645
SGTC_2340 7987427 183.45 µM 0.622512776990586 0.270147921782913 no 920 0.26680237245151 1305 2239331
SGTC_1838 st055369 84.5 µM 0.621404759145759 0.270519388266277 no 921 0.267166670757316 1272 676036
SGTC_2531 methyl deoxycholate 70.07 µM 0.620771473098023 0.270731813964313 no 922 0.267374997649853 1290 16667744 Haematoxylin.
SGTC_3054 9094397 49.47 µM 0.620043715141676 0.270976031559639 no 923 0.267614503340517 1286 2598354
SGTC_1892 st058411 7.36 µM 0.619539130757473 0.271145422112087 no 924 0.267780625903164 1321 3934738
SGTC_3032 9089427 49.47 µM 0.618379078596314 0.271535055367763 no 925 0.268162742769708 1278 17173707
SGTC_1680 diphenhydramine 100 µM 0.617524501015333 0.271822265421144 no 926 0.26844441287035 1337 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2754 granisetron 64.02 µM 0.617260497996657 0.271911023226819 no 927 0.268531458743148 1338 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2263 7948595 193.29 µM 0.617025867997069 0.271989917923064 no 928 0.268608831784326 1316 2971371
SGTC_280 3448-3607 3.04 µM 0.616729087454225 0.272089727139264 no 929 0.268706716019429 1292 626179
SGTC_2617 dihydrotanshinone i 20.83 µM 0.615942996388613 0.272354182611466 no 930 0.26896607134576 1334 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2662 daunorubicin 22.37 µM 0.614074745863373 0.272983208302234 no 931 0.269582967772885 1282 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2546 rhodinyl acetate 100 µM 0.613285870833941 0.273249032617654 no 932 0.269843667065471 1322 6708682
SGTC_1930 st074634 34.3 µM 0.61112084229706 0.273979232547223 no 933 0.270559791319571 1293 684253 YOR116C RPO31
SGTC_843 0310-0051 143 µM 0.609440481157989 0.274546632492911 no 934 0.271116256256855 1334 2065037
SGTC_2865 9030313 51.95 µM 0.609368212724279 0.274571048044504 no 935 0.271140201317583 1268 42562754
SGTC_3331 9141060 1.957 µM 0.608474246454483 0.274873158905675 no 936 0.271436490800384 1298 4906567 YPR165W RHO1
SGTC_542 3381-0244 89.3 µM 0.608421026776813 0.274891149361284 no 937 0.27145413461742 1359 1112843
SGTC_2152 5568786 200 µM 0.606194727100705 0.275644250315124 no 938 0.27219272690167 1306 5399883
SGTC_1863 st057641 20.1 µM 0.60449060339068 0.276221396900048 no 939 0.272758757322317 1320 3921635
SGTC_1937 st074714 47.2 µM 0.603814165705774 0.276450654726316 no 940 0.272983600176473 1288 17250970
SGTC_698 k064-0052 127 µM 0.603603622843385 0.276522030814671 no 941 0.273053601804919 1386 5088751
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.603422876610708 0.276583312760862 no 942 0.273113703699372 1395 23847180
SGTC_3128 9127691 49.47 µM 0.60340473788176 0.276589463058029 no 943 0.27311973556726 1344 41316314
SGTC_3317 9138495 8.753 µM 0.602617123632271 0.27685658398241 no 944 0.273381713113296 1325 17020139
SGTC_2482 5981709 142.65 µM 0.600708964515692 0.277504263263848 no 945 0.274016923590201 1352 877755
SGTC_1712 st032288 53.4 µM 0.600568173278573 0.277552080823694 no 946 0.274063820713022 1311 2883011
SGTC_1782 st039423 80.636 µM 0.599358007082659 0.277963260960581 no 947 0.274467086777652 1306 2068169
SGTC_2308 7584454 197.62 µM 0.599269134817482 0.277993468947737 no 948 0.274496713395371 1406 893577
SGTC_2813 7971799 71.43 µM 0.598528163914534 0.278245389831286 no 949 0.274743786191225 1388 2234054
SGTC_2449 5812982 45.77 µM 0.596656472382014 0.278882236906458 no 950 0.275368379634568 1328 776185
SGTC_2106 5357045 167.29 µM 0.595982484785284 0.279111736188673 no 951 0.275593463867918 1401 668842
SGTC_778 3456-2434 196 µM 0.594961807880554 0.279459461252363 no 952 0.27593450026862 1409 5539063
SGTC_187 1488-2104 32.728 µM 0.593428400940114 0.279982258748706 no 953 0.276447243291524 1380 2852859
SGTC_5 0352-0601 109.883 µM 0.593150604962435 0.280077020806791 no 954 0.276540183112607 1271 762456
SGTC_439 amiodarone 34.4 µM 0.591763330272651 0.280550481930684 no 955 0.27700454084595 1340 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1204 4049-0315 18.3 µM 0.591611122641995 0.280602452239428 no 956 0.277055512014946 1466 588402
SGTC_156 3474-0145 5.642 µM 0.59153330729687 0.280629023583899 no 957 0.277081572528386 1305 2265471
SGTC_2882 9058044 58.44 µM 0.591287689106171 0.280712901986738 no 958 0.277163838416238 1280 18076804
SGTC_2050 5263056 171 µM 0.590991664282756 0.280814010323214 no 959 0.277263003078084 1342 763468 YGL055W OLE1
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.590775233373126 0.28088794421546 no 960 0.277335515741388 1374 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2656 pseudo-anisatin 100 µM 0.590262712906287 0.281063061311532 no 961 0.277507266745314 1358 6708809 A neurotoxin.
SGTC_624 k048-0052 28 µM 0.589647631261863 0.281273290939267 no 962 0.277713455682271 1341 6835531
SGTC_2723 salbutamol 83.58 µM 0.589499827961086 0.281323820150053 no 963 0.277763013757353 1360 9884233 β2-adrenoceptor agonist
SGTC_1916 st067606 49.2 µM 0.588517152856554 0.281659876630501 no 964 0.278092612008139 1412 19590279
SGTC_588 3970-1144 52.9 µM 0.587511917552334 0.282003848431451 no 965 0.278429974440394 1328 1888707
SGTC_2338 7999974 200 µM 0.587251044145826 0.2820931472473 no 966 0.278517557554677 1401 315925
SGTC_997 3996-0078 137 µM 0.587230110916153 0.282100313430222 no 967 0.278524586056363 1378 735687
SGTC_95 0471-0001 561.058 µM 0.585773927158736 0.282599031496065 no 968 0.279013723503259 1270 4015405
SGTC_2009 4012297 12.05 µM 0.585511606832019 0.282688916756745 no 969 0.279101882248951 1350 45595307
SGTC_366 0181-0206 4.31 µM 0.581579718828711 0.284037839775399 no 970 0.280424903556094 1430 274874
SGTC_553 k007-0256 45.7 µM 0.581475115892169 0.284073768186223 no 971 0.280460142295303 1399 6287000
SGTC_2041 5107442 45.335 µM 0.580890274358102 0.284274686213744 no 972 0.280657203767841 1367 793005
SGTC_813 k007-0158 173 µM 0.58069513501496 0.284341740017099 no 973 0.280722970575385 1405 6523916
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.579312245794714 0.284817145029461 no 974 0.281189252062275 1410 279621
SGTC_650 1328-0195 38 µM 0.578762067339264 0.285006388935277 no 975 0.281374864741743 1358 2780821
SGTC_1992 st073643 23.3 µM 0.578186072868093 0.285204576953259 no 976 0.281569250260002 1376 3161292
SGTC_1436 4092-1007 8.32 µM 0.577404657807814 0.285473550967085 no 977 0.281833064221551 1344 2881121
SGTC_2287 7945887 168.79 µM 0.576165577131121 0.285900307319765 no 978 0.282251634950755 1391 1245853
SGTC_3018 9082602 49.47 µM 0.575462299323254 0.286142660678386 no 979 0.282489340470558 1363 17332089
SGTC_1672 st016598 6.51 µM 0.575348732074829 0.286181805720176 no 980 0.282527734841979 1332 4665860 YNL267W PIK1
SGTC_2414 st077232 92.9 µM 0.574184664530523 0.28658319009625 no 981 0.282921422836934 1332 729801
SGTC_2351 9026858 72.31 µM 0.573538198792422 0.286806214459166 no 982 0.283140171449918 1313 1409300
SGTC_987 1497-1013 404 µM 0.573431788502373 0.286842932852803 no 983 0.283176185935354 1361 1676435
SGTC_1353 1498-1206 8.11 µM 0.572559330282854 0.287144071030107 no 984 0.283471551637519 1403 6756808
SGTC_2427 5545055 42.75 µM 0.571897669369244 0.287372550039246 no 985 0.283695651537869 1430 5372858
SGTC_3175 9106517 49.47 µM 0.571606481969232 0.287473127592385 no 986 0.283794301543801 1340 41468073
SGTC_1034 k072-0165 12.7 µM 0.571158299114102 0.287627964664779 no 987 0.283946171385737 1428 5835461
SGTC_2710 st078562 53.7235 µM 0.568464304596756 0.288559508604478 no 988 0.284859868493468 1345 17250908
SGTC_1179 1021-1431 9.29 µM 0.567726356333374 0.288814928125025 no 989 0.28511039607428 1396 2840958
SGTC_1954 st077032 68.9 µM 0.566526455842629 0.289230466158521 no 990 0.285517976857399 1305 698907
SGTC_462 ag-879 158 µM 0.56586259940322 0.28946048724656 no 991 0.285743593943531 1422 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1330 1469-0054 61.8 µM 0.563569372128934 0.290255732974917 no 992 0.286523617905571 1441 7102664
SGTC_2385 9074692 200 µM 0.562649997839051 0.290574840877479 no 993 0.286836619568389 1360 17046906
SGTC_2699 st077704 54.6 µM 0.561588676994081 0.290943421354649 no 994 0.287198148420819 1419 645852
SGTC_1518 st038567 90.8 µM 0.554908835584483 0.293268227306344 no 995 0.289478509038831 1371 77966
SGTC_174 3553-0389 74.3 µM 0.553004268987123 0.293932653635886 no 996 0.290130243483074 1421 738071
SGTC_3264 9137442 49.47 µM 0.551367368240969 0.29450425780253 no 997 0.290690932684605 1471 17015726
SGTC_2334 9017922 200 µM 0.550962864050733 0.294645589286855 no 998 0.290829565949569 1520 3163164
SGTC_460 trequinsin 123 µM 0.550413054722748 0.29483773971325 no 999 0.291018048302753 1439 5537 A vasodilator.
SGTC_233 rapamycin 362 pM 0.547193390541933 0.295964123641092 no 1000 0.292122938254485 1441 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3307 9126885 69.2785 µM 0.545266863050131 0.296639053326192 no 1001 0.29278499556031 1383 24824909
SGTC_3051 9093778 49.47 µM 0.545019089765009 0.296725908076078 no 1002 0.292870194176159 1421 17217378
SGTC_691 1548-0686 185 µM 0.544676149566621 0.296846141959325 no 1003 0.292988135598723 1383 46495133
SGTC_1272 0839-0021 27 µM 0.544292052763331 0.296980831699618 no 1004 0.293120257449269 1410 5027250
SGTC_1856 st057054 55.7 µM 0.543501194932595 0.297258246759958 no 1005 0.293392384184943 1536 1266018
SGTC_2080 5212524 12.4 µM 0.542863948318608 0.297481864593513 no 1006 0.293611739867051 1451 260183
SGTC_1137 ixabepilone 100 µM 0.542567031462491 0.297586082670882 no 1007 0.293713971747061 1389 154225 A novel microtubule stabilizer.
SGTC_798 1287-0182 476 µM 0.538961443009347 0.298852975094763 no 1008 0.294956729734613 1498 1649755
SGTC_873 0591-4978 488 µM 0.538400259966185 0.299050377673933 no 1009 0.295150373470929 1572 3305145
SGTC_2225 6654152 15.4 µM 0.537385792895627 0.299407378274012 no 1010 0.295500577415071 1447 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2115 tiliquinol 12.7705 µM 0.536973277032457 0.299552601773079 no 1011 0.295643036551483 1451 71208 A bioactive hydroxyquinoline.
SGTC_2853 9015042 58.44 µM 0.535249674020286 0.300159729937548 no 1012 0.296238610627978 1347 6457456
SGTC_2183 6420625 130.508 µM 0.535189916246681 0.300180789209225 no 1013 0.296259269206061 1411 2897619
SGTC_2135 5326629 150.42 µM 0.534576540357484 0.300396987973727 no 1014 0.296471354678591 1399 5020077
SGTC_431 k089-0097 107 µM 0.532863417996379 0.301001190558472 no 1015 0.297064065008922 1373 5499420
SGTC_1372 2752-0194 270 µM 0.531593379660477 0.301449474774726 no 1016 0.297503825503899 1385 823334
SGTC_1655 st012546 55.1 µM 0.530822270732562 0.301721798871959 no 1017 0.297770972810709 1406 720985 YLR208W SEC13
SGTC_779 1360-0071 233 µM 0.52981433450268 0.302077927356702 no 1018 0.298120332796305 1599 7566
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.529172820122514 0.302304688299659 no 1019 0.298342784792418 1404 61125 An anti-inflammatory.
SGTC_660 4031-1742 102 µM 0.528742258699974 0.302456924919532 no 1020 0.298492128948201 1414 6738706
SGTC_307 1501-1223 22.3 µM 0.528416277173498 0.302572207352534 no 1021 0.298605221231849 1431 2830329
SGTC_1300 1094-0077 113 µM 0.528086764492734 0.302688758578922 no 1022 0.298719558373515 1406 5532636
SGTC_129 0088-0017 176.636 µM 0.527779264898774 0.302797541742481 no 1023 0.298826275173518 1447 182446
SGTC_2630 antimycin a 100 µM 0.527607791302544 0.302858211019555 no 1024 0.29888579208704 1378 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_181 1447-1644 8.07 µM 0.527533888092488 0.302884360480393 no 1025 0.298911444874433 1434 534600
SGTC_611 3453-1652 23.7 µM 0.52693677282291 0.303095677167723 no 1026 0.299118748204923 1494 1560575
SGTC_606 k015-0008 38.6 µM 0.524254295272872 0.304045807652143 no 1027 0.300050840671212 1559 1970475
SGTC_2369 9071472 200 µM 0.523372627140255 0.304358383131644 no 1028 0.300357484494876 1498 17296037
SGTC_657 3534-0529 86.7 µM 0.52151104347881 0.305018834934086 no 1029 0.301005407235299 1531 1049549
SGTC_1153 4055-0057 267 µM 0.52054205296022 0.305362864629348 no 1030 0.301342912778144 1409 882706
SGTC_1933 st074711 15.9 µM 0.520103421521075 0.305518652584098 no 1031 0.301495746890405 1409 17250958
SGTC_1033 k072-0102 21.3 µM 0.52005079174297 0.305537347376548 no 1032 0.301514087238588 1545 5965931
SGTC_1884 5633444 25 µM 0.5194529196037 0.305749755044059 no 1033 0.301722468080728 1473 5724239
SGTC_3328 9140624 29.0385 µM 0.51871876052073 0.306010671163914 no 1034 0.301978438563238 1550 4904392
SGTC_1513 0337-0559 19 µM 0.517818234056815 0.306330847793391 no 1035 0.302292547505825 1389 775073
SGTC_1643 st009866 20.2 µM 0.51770619716654 0.306370692171197 no 1036 0.302331636885282 1463 3156273 YOR207C RET1
SGTC_2830 7992007 71.43 µM 0.516619217725371 0.306757380258238 no 1037 0.302710998838613 1473 1952075
SGTC_1948 st076329 66.6 µM 0.512245453211155 0.308315498731281 no 1038 0.304239617741584 1386 24208413
SGTC_2191 5911152 200 µM 0.512081388064707 0.308374013112419 no 1039 0.304297024920551 1473 2875902
SGTC_2567 aureobasidin a 60 nM 0.511977650492886 0.308411013975603 no 1040 0.304333325681885 1548 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2173 5763948 167 µM 0.510815384542369 0.308825701130578 no 1041 0.30474016772533 1461 2867177
SGTC_1215 3852-0577 11.2 µM 0.510223520431203 0.309036967230738 no 1042 0.304947437969024 1569 2884876
SGTC_909 3448-9333 149 µM 0.508852590126294 0.309526563850613 no 1043 0.305427776792428 1440 3344074
SGTC_2403 6032726 181.2 µM 0.50868011109242 0.309588184791368 no 1044 0.305488232775786 1468 2881040
SGTC_912 3474-0017 2.18 µM 0.507449784054613 0.310027894335753 no 1045 0.30591963104501 1561 3360550
SGTC_1239 0337-0584 35.4 µM 0.504985020107326 0.310909599591521 no 1046 0.306784678675521 1616 914301 YML130C ERO1
SGTC_955 1216-0110 33 µM 0.50053427867185 0.312504487264632 no 1047 0.308349462862096 1415 3619719
SGTC_2232 chlorophetanol 41.5365 µM 0.500506356886345 0.312514503948561 no 1048 0.308359290596198 1572 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_400 oxethazaine 37.5 µM 0.499608140546463 0.312836804668316 no 1049 0.308675512365139 1471 4621 A local anesthetic.
SGTC_1673 st016611 27.3 µM 0.498467804221864 0.313246189800388 no 1050 0.309077178204118 1559 5226799
SGTC_2045 5106652 78.05 µM 0.498219119029825 0.313335499342753 no 1051 0.309164804064969 1524 673349
SGTC_278 4092-0821 23.9 µM 0.495748413308154 0.314223390218129 no 1052 0.310035962577513 1520 877900
SGTC_356 1634-0012 32.5 µM 0.495123747420202 0.314448045355623 no 1053 0.310256385908067 1523 735457
SGTC_1263 0774-1208 64.8 µM 0.49489054432212 0.314531932252444 no 1054 0.310338692826467 1605 906585
SGTC_315 k915-0449 187 µM 0.492526103268442 0.315382999770197 no 1055 0.311173736701312 1549 20970215 YNL149C PGA2
SGTC_1347 1493-0251 600 nM 0.491355284220909 0.315804792888808 no 1056 0.311587592426797 1585 3986378
SGTC_2250 alverine citrate 130 µM 0.491159450259894 0.315875366443683 no 1057 0.311656838173774 1461 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2731 amoxapine 43.43 µM 0.490793754834755 0.31600717169787 no 1058 0.311786163775105 1565 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_514 4466-0038 2.65 nM 0.487751796197907 0.317104470589639 no 1059 0.312862829361794 1530 5722064
SGTC_289 k017-0060 526 µM 0.486395262819209 0.317594320626998 no 1060 0.313343474305626 1490 5512909
SGTC_671 0560-0003 407 µM 0.486009732297629 0.317733595703644 no 1061 0.313480132843683 1534 3238678
SGTC_1090 efavirenz 20.7 µM 0.484968672083961 0.318109813407486 no 1062 0.313849284096261 1526 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_620 0109-0052 432 µM 0.48400492130573 0.318458260450857 no 1063 0.314191188248603 1563 493037
SGTC_2883 9059145 45.46 µM 0.483658414027302 0.318583580496586 no 1064 0.314314155582942 1486 16476510
SGTC_1731 st035964 63 µM 0.482240920948711 0.319096456136379 no 1065 0.314817405230758 1506 6739575
SGTC_2394 5221648 200 µM 0.481880980357206 0.319226744607933 no 1066 0.314945249014213 1659 788586
SGTC_127 0180-0333 59.125 µM 0.481686045503384 0.319297314919276 no 1067 0.315014495279219 1480 771601
SGTC_1935 st074532 41.6 µM 0.479419133922405 0.320118462421201 no 1068 0.315820242082636 1647 2829742
SGTC_861 0443-0273 110 µM 0.478420508722996 0.320480476306817 no 1069 0.316175469739057 1531 6149169
SGTC_1250 0485-0349 40.2 µM 0.478300422991345 0.320524020373139 no 1070 0.316218197678117 1503 6842794 YDL195W SEC31
SGTC_348 k064-0012 10.7 µM 0.477270212176116 0.32089768467828 no 1071 0.316584859795564 1475 5066323
SGTC_1860 st056228 74.6 µM 0.476544201071196 0.321161122771912 no 1072 0.316843362593779 1479 688679
SGTC_2379 9035213 200 µM 0.47509574525121 0.321686973740961 no 1073 0.317359365497048 1645 646551
SGTC_1597 7-benzyloxygramine 47.5 µM 0.474816107285136 0.321788535391577 no 1074 0.31745902562598 1492 260807
SGTC_897 1000-0139 31.4 µM 0.473576539935282 0.322238893840836 no 1075 0.317900954091742 1623 6151020
SGTC_358 0075-0058 9.45 µM 0.473358330037875 0.322318200700397 no 1076 0.317978776793965 1724 1069125
SGTC_215 1287-0124 461.5 µM 0.473038590711988 0.322434422328133 no 1077 0.318092823621198 1607 5560863
SGTC_1743 st037606 46.3785 µM 0.471729760527305 0.322910348129672 no 1078 0.318559845933796 1537 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2399 5884133 200 µM 0.47153667956171 0.322980582130232 no 1079 0.318628766327923 1499 722445
SGTC_1047 2043-3044 82 µM 0.469864782224843 0.323589005475944 no 1080 0.319225813531039 1461 669592
SGTC_1622 st003707 19.4 µM 0.468743857767518 0.323997187595859 no 1081 0.319626366969007 1554 10140899
SGTC_419 nsc-638432 893 µM 0.468276336695958 0.32416749693618 no 1082 0.319793494139846 1525 368090
SGTC_1086 cerivastatin 2.18 µM 0.466357255680482 0.324866968151075 no 1083 0.320479901015787 1551 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2652 actinonin 100 µM 0.46495531048302 0.325378343221759 no 1084 0.320981730050645 1536 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3303 9125618 40.5795 µM 0.463782346172147 0.325806447778533 no 1085 0.321401846376877 1621 22695467
SGTC_1642 st009582 77.7 µM 0.463186989799924 0.326023826893627 no 1086 0.321615170477332 1604 6739311
SGTC_649 1123-0311 367 µM 0.462358865280295 0.326326293662497 no 1087 0.321911996321106 1533 693629 YIL048W NEO1
SGTC_1899 st063254 59.6 µM 0.461715393836603 0.326561396060808 no 1088 0.322142715189216 1455 3093813
SGTC_605 1315-0399 119 µM 0.461688335930858 0.326571283601849 no 1089 0.322152418395616 1590 24020461
SGTC_546 peri-Naphthalide 147 µM 0.460941319455036 0.326844307589249 no 1090 0.322420353017952 1623 223824 A penicillin ester.
SGTC_3012 9080433 71.4286 µM 0.460834002238951 0.326883538139505 no 1091 0.322458852386251 1628 17688859
SGTC_827 3253-0474 693 µM 0.460022307128622 0.327180320843281 no 1092 0.32275010447954 1641 5402065
SGTC_1703 st026983 48.3 µM 0.459973537519305 0.327198156115714 no 1093 0.322767607435548 1624 1104023
SGTC_76 0433-0009 400.328 µM 0.459970709258302 0.327199190435992 no 1094 0.322768622483978 1543 2841569
SGTC_2948 9070189 9.45 µM 0.459138479150452 0.327503602025658 no 1095 0.323067362954835 1615 6473636 YDL196W YDL196W
SGTC_2735 sertaconazole 140 nM 0.459032839459216 0.32754225092576 no 1096 0.323105291947961 1597 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_53 0973-0023 39.979 µM 0.458113769363528 0.327878576052102 no 1097 0.323435353478929 1596 674768
SGTC_1462 k081-0014 26.5 µM 0.457810289937368 0.327989662199014 no 1098 0.323544371224574 1418 3270634
SGTC_1745 st081495 74 µM 0.457199963817541 0.328213113124304 no 1099 0.323763662182038 1566 13842402 YBL026W LSM2
SGTC_2296 7971656 126.45 µM 0.456467066082545 0.328481520872758 no 1100 0.324027074142262 1530 666570
SGTC_1103 duloxetine 36.1 µM 0.456167353212626 0.328591309663318 no 1101 0.324134819827285 1643 60835 A selective serotonin reuptake inhibitor.
SGTC_881 0833-0569 170 µM 0.453730173506735 0.329484629579702 no 1102 0.325011523347084 1491 5418700
SGTC_810 3825-7150 143 µM 0.45248881632004 0.329940009379596 no 1103 0.325458438103118 1711 22330411 YGL099W LSG1
SGTC_1760 st045453 10.4495 µM 0.452439066448288 0.329958264894888 no 1104 0.325476354342746 1600 3323419 YIL048W NEO1
SGTC_124 0136-0217 7.121 µM 0.452298749066604 0.330009755975283 no 1105 0.325526888501604 1643 3976905
SGTC_2681 menadione 3.18 µM 0.451816757715624 0.330186652783309 no 1106 0.325700498174957 1561 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_664 1222-0054 14.9 µM 0.451558740422462 0.330281363936532 no 1107 0.325793449611002 1547 6813991
SGTC_1326 1431-2094 10.8 µM 0.450871701352723 0.330533610369369 no 1108 0.326041010117797 1514 616278
SGTC_109 0132-0036 33.701 µM 0.450075922933471 0.330825876706456 no 1109 0.326327848490947 1502 67274 A color developer.
SGTC_2360 9040895 200 µM 0.448230323596515 0.331504108621319 no 1110 0.326993490123883 1523 4914414
SGTC_1026 k007-1105 30.6 µM 0.446939212820818 0.331978902582465 no 1111 0.327459475169271 1544 7066794
SGTC_2178 5812956 200 µM 0.445326264543723 0.33257242847949 no 1112 0.328041994972046 1568 5403383
SGTC_421 streptovitacin 30 mM 0.444158363992878 0.333002449833213 no 1113 0.32846404614647 1573 91467 include heat shock
SGTC_2838 9002687 71.43 µM 0.444106850009869 0.333021422361157 no 1114 0.328482667107177 1511 6457060
SGTC_3066 9117245 49.47 µM 0.443241065728033 0.33334035342824 no 1115 0.328795689249916 1656 17176980
SGTC_1956 st077085 54 µM 0.441537070855492 0.333968410055278 no 1116 0.329412115090244 1542 24208685
SGTC_1603 st002045 67.8 µM 0.441200896532131 0.334092371843216 no 1117 0.329533782116212 1612 5887985
SGTC_2302 7771753 200 µM 0.439521199875172 0.334712018468387 no 1118 0.330141962146392 1520 2203047
SGTC_2293 7624732 200 µM 0.437529068867277 0.335447507135415 no 1119 0.330863849704084 1485 894453
SGTC_773 4358-1457 44.6 µM 0.436655559068145 0.335770203468884 no 1120 0.331180581689175 1721 1186886
SGTC_146 3448-8650 53.125 µM 0.435161508754951 0.336322423644559 no 1121 0.331722599741878 1597 2891488 YIL048W NEO1
SGTC_191 3914-0123 66.505 µM 0.434591101994886 0.336533346566683 no 1122 0.33192962741601 1512 3144412
SGTC_2969 9091408 28.7 µM 0.4338014452228 0.336825427852118 no 1123 0.332216316021676 1498 4286311
SGTC_3094 9117742 49.47 µM 0.433065871585529 0.337097593223485 no 1124 0.332483457856534 1515 17149698
SGTC_2732 terfenadine 20 µM 0.431456523468031 0.337693356150956 no 1125 0.333068229248342 1586 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1710 st031758 61.5 µM 0.430770500818421 0.337947437969383 no 1126 0.33331762541547 1653 5394341
SGTC_3075 9116269 49.47 µM 0.430522663665496 0.33803924743972 no 1127 0.333407742080984 1591 17015205 YNL244C SUI1
SGTC_2679 rapamycin 1 nM 0.429864832512225 0.338282982914895 no 1128 0.333646984277672 1588 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3310 9130229 44.1445 µM 0.429079023318314 0.338574224852092 no 1129 0.333932858629353 1639 7761258
SGTC_2210 7115885 190.385 µM 0.428164760017879 0.33891319685353 no 1130 0.334265585411842 1584 2927039
SGTC_1707 st032323 6.317 µM 0.427305771782523 0.339231793981772 no 1131 0.334578314705233 1589 3132057 YMR211W DML1
SGTC_3169 9102970 49.47 µM 0.42663113799272 0.339482095017016 no 1132 0.334824007125763 1614 17027839
SGTC_397 arbidol 50 µM 0.425745708905896 0.339810712292007 no 1133 0.335146575628511 1672 131410 A RNA synthesis inhibitor.
SGTC_1901 st060216 58.6 µM 0.42456942513085 0.340247465415051 no 1134 0.335575292764946 1567 688792
SGTC_3008 9078912 71.4286 µM 0.422785893316365 0.340910098063564 no 1135 0.33622574041709 1571 16648731
SGTC_2694 st077685 81.9 µM 0.420610546721631 0.34171896569346 no 1136 0.33701974552553 1541 2838096
SGTC_3210 9128157 49.47 µM 0.4195178915894 0.342125526566273 no 1137 0.337418840877647 1547 17590849
SGTC_2605 digitonin 300 nM 0.419192438153538 0.342246658403452 no 1138 0.337537749043924 1681 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2663 amphotericin b 100 µM 0.417358531672027 0.342929530653392 no 1139 0.338208090903555 1608 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1527 coumarin 137 µM 0.41733062809325 0.342939924783024 no 1140 0.338218294376731 1655 323 A hepatotoxic, DNA x-linker.
SGTC_2516 gossypol 71.55 µM 0.417003262034262 0.343061878061851 no 1141 0.338338010861962 1729 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1023 4482-3888 16 µM 0.416531371257255 0.343237699724791 no 1142 0.338510608227507 1693 3303168
SGTC_985 1493-0307 8.71 µM 0.415357841294304 0.343675092026375 no 1143 0.338939982088189 1718 3278274
SGTC_801 0866-0028 10.1 µM 0.415302532099311 0.343695711767444 no 1144 0.338960223914116 1621 6849771
SGTC_136 0097-0015 404.482 µM 0.414905887682438 0.343843597821647 no 1145 0.33910539978539 1637 4861337
SGTC_1468 k284-1086 134 µM 0.41229449547736 0.344817832483654 no 1146 0.340061791375276 1612 15996457
SGTC_2373 9071805 200 µM 0.412055459371704 0.344907061464609 no 1147 0.340149387080448 1762 10149009
SGTC_524 r073-0010 27.8 µM 0.411877027870858 0.344973673180351 no 1148 0.340214779618283 1559 2772106
SGTC_680 0417-1641 114 µM 0.410817678434553 0.345369246420298 no 1149 0.340603114616599 1588 2835990
SGTC_1941 st076221 61.8 µM 0.409151592227596 0.345991723847091 no 1150 0.341214208276061 1731 2828568
SGTC_3022 9087993 49.47 µM 0.406709658428351 0.346904822909265 no 1151 0.342110622946018 1659 17173644
SGTC_221 trifluoperazine 10.304 µM 0.406703823902942 0.346907005649298 no 1152 0.34211276582278 1605 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_940 3232-1287 54.8 µM 0.406267087172196 0.347070406578314 no 1153 0.342273182845121 1645 1585493 YIL048W NEO1
SGTC_1258 0671-0043 57.1 µM 0.406140424939847 0.347117801379166 no 1154 0.342319712259328 1565 4298767
SGTC_1761 st044296 37 µM 0.405719049089438 0.347275490089165 no 1155 0.342474522045395 1579 1826700
SGTC_1902 st060212 70.5 µM 0.403854240097382 0.347973662393021 no 1156 0.343159953939228 1591 688944
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.403452738512763 0.348124049513023 no 1157 0.343307598072235 1699 688761
SGTC_3347 9188721 44.724 µM 0.402943096586196 0.348314976266596 no 1158 0.343495043087734 1651 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2024 5144227 134 µM 0.401176737709835 0.34897700315775 no 1159 0.344145003101741 1686 3475211
SGTC_922 1866-0035 480 µM 0.401150703060699 0.348986764323681 no 1160 0.344154586417181 1658 3156169
SGTC_2157 5649910 96.377 µM 0.399898396575522 0.349456409252926 no 1161 0.344615676657359 1574 2858091
SGTC_2661 dactinomycin 12.96 µM 0.399622185256803 0.349560026172019 no 1162 0.34471740678905 1635 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1378 2093-0007 380 nM 0.398018863805463 0.350161711575168 no 1163 0.345308140377569 1633 3618014
SGTC_1150 3909-7983 10.9 µM 0.395988128277227 0.350924334563168 no 1164 0.346056893088255 1589 23965914
SGTC_1938 st074717 56.4 µM 0.395813503803193 0.350989941188645 no 1165 0.346121307058783 1578 17250979
SGTC_186 3455-3465 67.277 µM 0.395175965898001 0.35122950265071 no 1166 0.346356514333215 1631 755278
SGTC_1758 st042942 75.2445 µM 0.394601415037167 0.351445446734926 no 1167 0.346568534530476 1657 669317
SGTC_1677 st019204 53.9 µM 0.393097662827137 0.352010856620122 no 1168 0.347123675119097 1570 3945625
SGTC_574 1315-0397 40 µM 0.392425211415087 0.352263803933022 no 1169 0.347372030457485 1622 6794277
SGTC_339 3091-4833 71.4 µM 0.390152126368946 0.353119324171227 no 1170 0.348212029802617 1676 3240077
SGTC_1277 0873-0036 22 µM 0.38983800145639 0.353237609781931 no 1171 0.348328170702231 1741 5965735
SGTC_1840 st055363 71 µM 0.389708224040403 0.353286482382404 no 1172 0.348376157250381 1571 676033
SGTC_1751 st044839 27.194 µM 0.388927920611887 0.353580386171716 no 1173 0.348664733693839 1670 5291326
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.388153738909836 0.353872070482728 no 1174 0.34895113272739 1750 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_601 0986-0029 62.9 µM 0.385448125630433 0.354892122814572 no 1175 0.349952716314022 1647 24747981
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.384762898080545 0.355150628262723 no 1176 0.350206544929031 1716 688751
SGTC_60 0986-0278 202 µM 0.384206583595226 0.355360549675156 no 1177 0.350412669552314 1478 3110598
SGTC_2846 9008642 19.48 µM 0.383972556710546 0.355448871216662 no 1178 0.350499393934279 1632 2992898
SGTC_736 0958-0254 92.6 µM 0.383333903706074 0.355689937790951 no 1179 0.35073610205634 1703 6812352
SGTC_492 tmb-8 126 µM 0.38305969020711 0.355793460400662 no 1180 0.350837753380616 1724 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2073 5212005 126 µM 0.382494366114535 0.356006918263674 no 1181 0.351047353497617 1726 691789
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.381540422867216 0.356367215196307 no 1182 0.351401141181464 1628 16486 A toxic proline analog.
SGTC_513 4245-1575 41.7 µM 0.381229750392504 0.356484581469515 no 1183 0.351516387690663 1746 719745
SGTC_2728 chlorpromazine 9.18 µM 0.380913997259584 0.356603881048754 no 1184 0.351633532898754 1681 2726 A thorazine and dopamine antagonist.
SGTC_662 k832-1615 104 µM 0.380049041679759 0.356930755134514 no 1185 0.351954505735755 1708 5878478
SGTC_87 0100-0052 35.5 µM 0.379600417229615 0.357100335531528 no 1186 0.352121025527366 1709 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_538 2922-0838 53.3 µM 0.379570036139668 0.357111820628669 no 1187 0.352132303363192 1783 777039
SGTC_3003 9075612 71.4286 µM 0.378049828358508 0.357686676599709 no 1188 0.352696789149811 1668 6501993
SGTC_145 3737-0113 38.366 µM 0.377325205305542 0.357960801500509 no 1189 0.352965971521229 1791 6849351
SGTC_1594 piperine 70.1 µM 0.377200698428678 0.358007909830765 no 1190 0.353012230646565 1620 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.376891996327932 0.358124719455289 no 1191 0.353126934798991 1597 6708514
SGTC_2593 nobiletin 86.24 µM 0.376601974550405 0.358234472743023 no 1192 0.353234710080578 1614 72344 An anti-infammatory.
SGTC_1654 st012436 41.8 µM 0.375189654274454 0.358769106067828 no 1193 0.353759711927452 1731 4323132
SGTC_264 promethazine 12.5 mM 0.373853164329519 0.359275288821382 no 1194 0.354256781634513 1654 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_904 1141-0088 396 µM 0.373788553408401 0.359299765856854 no 1195 0.354280818144008 1578 1378119
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.373637696569371 0.359356918322398 no 1196 0.354336942059192 1618 4330530
SGTC_52 0329-0193 875 nM 0.372798248859533 0.359675002488429 no 1197 0.354649303131357 1754 3739292
SGTC_853 0419-0306 21 µM 0.370972629932889 0.360367102820253 no 1198 0.355328958802204 1611 762713
SGTC_296 1222-0039 74.9 µM 0.370081693207699 0.360705027298472 no 1199 0.355660810992218 1613 5984176
SGTC_2729 fluphenazine 10.66 µM 0.369454310746979 0.360943053255308 no 1200 0.355894561328046 1600 3372 An atypical antipsychotic.
SGTC_1990 st072050 59.8 µM 0.367239652470611 0.361783714320453 no 1201 0.356720132052413 1637 17233948
SGTC_1465 k213-0056 144 µM 0.366662593259265 0.362002869725145 no 1202 0.356935356144062 1660 24048857 YMR208W ERG12
SGTC_2320 7373003 200 µM 0.365738648950327 0.362353859277216 no 1203 0.357280051770928 1598 5415828
SGTC_2077 5212015 200 µM 0.365026481279804 0.36262447776224 no 1204 0.357545819469887 1606 780900
SGTC_685 1278-0033 54.9 µM 0.363409610225513 0.363239131531229 no 1205 0.358149461944059 1756 3590572
SGTC_1480 1070-0044 41.2 µM 0.362722511781732 0.363500438879909 no 1206 0.358406090708565 1745 3124987
SGTC_398 bronopol 33.3 µM 0.361082787719653 0.364124291513208 no 1207 0.359018779948171 1710 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1857 st056007 79.3 µM 0.360576765945615 0.364316886364348 no 1208 0.359207930277779 1715 619834
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.360185731441732 0.364465739859612 no 1209 0.359354122148268 1740 1241132 A phosphatase inhibitor.
SGTC_1835 st008666 49.2 µM 0.360131170297491 0.364486511051381 no 1210 0.359374521974797 1638 690455
SGTC_2704 st078022 71.1 µM 0.359895019014052 0.364576417411684 no 1211 0.359462821027711 1819 54697681
SGTC_1872 amphotericin b 148 nM 0.359477681913278 0.364735322162137 no 1212 0.359618885407877 1767 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_555 4296-0685 37 µM 0.357022692962074 0.365670550325619 no 1213 0.360537408632019 1729 2908540 YHR072W ERG7
SGTC_1705 st027868 56.3335 µM 0.356720902487211 0.365785572682064 no 1214 0.360650377887717 1787 292948
SGTC_502 l-744,832 89.3 µM 0.356314684598788 0.365940414838961 no 1215 0.360802456668146 1806 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2132 5317594 122.667 µM 0.355060442559665 0.366418644602714 no 1216 0.36127215531132 1742 794577
SGTC_1848 st056003 16.4 µM 0.354725230267367 0.366546492819496 no 1217 0.361397723762738 1761 146492
SGTC_7 0192-1582 4.227 µM 0.35448009173376 0.366639996751419 no 1218 0.36148956059454 1720 252616
SGTC_1706 st031321 9.9705 µM 0.354417105292756 0.366664023138362 no 1219 0.361513158643636 1778 6103185
SGTC_1666 st014829 29 µM 0.354149832442631 0.366765981065181 no 1220 0.361613299035818 1665 3858230
SGTC_1384 3089-0840 101 µM 0.353998813753828 0.366823595085724 no 1221 0.361669886119116 1793 1069836
SGTC_2724 maprotiline 69.64 µM 0.352256640913601 0.367488455169495 no 1222 0.362322901140135 1754 4011 A tricyclic antidepressant.
SGTC_1515 3460-0031 42.1 µM 0.352113903736017 0.367542945161211 no 1223 0.362376420810315 1728 2876596
SGTC_440 fluspirilene 35.1 µM 0.350230311140533 0.368262257026588 no 1224 0.363082930275971 1773 3396 An atypical antipsychotic.
SGTC_1106 tegaserod maleate 11.7 µM 0.348470771101243 0.368934612818526 no 1225 0.363743330575639 1730 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_172 1112-0046 2.638 µM 0.348305299128364 0.368997863676867 no 1226 0.363805457296661 1710 2802135 YIL048W NEO1
SGTC_939 1165-0479 45.3 µM 0.345773237799096 0.369966173389571 no 1227 0.364756569565982 1804 1377347
SGTC_1463 k081-0032 34.1 µM 0.344552557438018 0.370433280502079 no 1228 0.365215388821857 1628 977755
SGTC_16 erodoxin 22.806 µM 0.343175159025458 0.370960587005356 no 1229 0.365733345709969 1726 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2102 5377816 72.7585 µM 0.343148631226916 0.370970744968354 no 1230 0.365743323629536 1837 1379702
SGTC_2123 5259487 200 µM 0.342718633633114 0.371135411184192 no 1231 0.365905071591718 1809 2173474
SGTC_1756 st041558 35.5 µM 0.342117210070562 0.371365764006835 no 1232 0.366131343155184 1879 3955792
SGTC_193 1273-0060 1.558 µM 0.339900291183626 0.372215269374324 no 1233 0.366965808675035 1789 2847393 YHR072W ERG7
SGTC_3136 9095672 49.47 µM 0.339154635351513 0.372501138704953 no 1234 0.367246620881026 1853 17217380
SGTC_2876 9059903 25.97 µM 0.338110543537941 0.372901540374214 no 1235 0.367639942686354 1719 6916095
SGTC_1387 3342-1166 1.8 µM 0.337851842959433 0.373000771425537 no 1236 0.367737419753954 1740 3418228
SGTC_2514 salinomycin 42.74 µM 0.33754233901464 0.373119500443955 no 1237 0.367854050466293 1877 23682228 A polyether potassium ionophore.
SGTC_2348 9022543 33.42 µM 0.337419829276449 0.373166499817319 no 1238 0.367900219312561 1749 3162678 YDL140C RPO21
SGTC_2809 7964133 12.99 µM 0.335923337838713 0.373740762727256 no 1239 0.368464338814669 1748 1253665
SGTC_603 3794-0023 45.9 µM 0.335378080124989 0.373950069429277 no 1240 0.368669950487964 1821 3802260
SGTC_338 4055-0136 114 µM 0.335321455335748 0.373971807975784 no 1241 0.368691305331876 1688 2900563
SGTC_2836 9010338 19.48 µM 0.33503461412287 0.374081933942786 no 1242 0.368799487668292 1576 2994051
SGTC_882 0843-0131 351 µM 0.334798620072754 0.374172546038751 no 1243 0.368888500762769 1791 5425421
SGTC_1530 rhein 70.4 µM 0.334727072215686 0.374200018873082 no 1244 0.368915488833415 1747 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1266 0828-0227 32.9 µM 0.334583164874514 0.374255278123666 no 1245 0.368969773080191 1791 3913820
SGTC_2200 6600604 21.907 µM 0.333559468797015 0.374648443599182 no 1246 0.36935600366762 1717 2904777
SGTC_223 busulfan 5 mM 0.333466377273723 0.374684203234108 no 1247 0.36939113274357 1788 2478 A DNA alkylator.
SGTC_1753 st043925 64 µM 0.333304937320323 0.374746220391236 no 1248 0.369452056411522 1857 670181
SGTC_67 0335-0847 266 µM 0.331741448720677 0.37534700191439 no 1249 0.370042249896965 1930 4552207 YOR254C SEC63
SGTC_446 go6976 132 µM 0.331660494159502 0.375378117523952 no 1250 0.370072817377719 1850 3501 A protein kinase C inhibitor.
SGTC_1460 k062-0059 9.15 µM 0.33126345966245 0.375530733019236 no 1251 0.370222744767854 1665 1373085
SGTC_807 1315-0151 48 µM 0.331232266493982 0.375542724140142 no 1252 0.370234524706912 1862 4011080
SGTC_2934 9036370 36.88 µM 0.329986872272761 0.376021570431264 no 1253 0.370704940734322 1845 6462800
SGTC_759 3486-0358 89.3 µM 0.329635777080769 0.376156598872843 no 1254 0.370837592991466 1895 875103
SGTC_344 k064-0035 6.43 µM 0.329315410793236 0.376279822449589 no 1255 0.370958648521861 1670 5088750
SGTC_3152 9099253 49.47 µM 0.329008332450461 0.376397946877149 no 1256 0.37107469497832 1797 25236131
SGTC_3150 9097574 49.47 µM 0.328890189499357 0.376443396241971 no 1257 0.371119344919923 1858 17217476
SGTC_1500 4488-1866 171 µM 0.328248636339908 0.376690230395222 no 1258 0.371361838338467 1830 2900003
SGTC_1320 1313-0481 95.3 µM 0.327790176301329 0.376866651342835 no 1259 0.371535157753978 1864 6813365 YLR208W SEC13
SGTC_3079 9117512 49.47 µM 0.32775958297862 0.376878424937669 no 1260 0.371546724393528 1794 7185044
SGTC_1395 3486-0190 4.35 µM 0.327379601514347 0.377024667295122 no 1261 0.371690396406764 1872 6748079
SGTC_894 0960-0238 55.9 µM 0.326718081841209 0.377279306523831 no 1262 0.371940561407074 1798 6741907 YDL195W SEC31
SGTC_3194 9111903 49.47 µM 0.326675726151635 0.377295612347986 no 1263 0.371956580779905 1790 17087251
SGTC_2081 5214970 32.255 µM 0.326331165326097 0.377428267310566 no 1264 0.372086905586808 1838 2063512
SGTC_3046 9092212 49.47 µM 0.325649848955133 0.377690614783002 no 1265 0.372344646098623 1736 25236637
SGTC_291 SEC14.278 35.5 µM 0.3255110969011 0.377744049526783 no 1266 0.372397142714092 1827 1068044
SGTC_640 3381-0960 37.1 µM 0.322992808927237 0.378714271953409 no 1267 0.373350344043618 1814 1745025
SGTC_3237 9133362 49.47 µM 0.321933634803305 0.379122569513626 no 1268 0.373751485817338 1792 43845137
SGTC_1974 st069448 26.9 µM 0.320132221011269 0.379817300202284 no 1269 0.374434050537559 1864 6323587 YNR016C ACC1
SGTC_1244 0416-0015 52.5 µM 0.318018002996669 0.380633161423758 no 1270 0.37523564043401 1755 96201
SGTC_2799 7812892 81.82 µM 0.317118035457943 0.380980613679323 no 1271 0.375577020154518 1855 20205235
SGTC_1217 1183-1422 255 µM 0.316668952625956 0.381154027897548 no 1272 0.375747404726063 1831 2849664
SGTC_119 0121-0043 24.815 µM 0.314145568419473 0.382128880603973 no 1273 0.376705240729124 1793 1092378
SGTC_1697 st025554 27.742 µM 0.310984948699122 0.3833509691649 no 1274 0.377906031953553 1737 1269519
SGTC_3105 9121040 49.47 µM 0.309348893282704 0.383984025147366 no 1275 0.378528071080776 1870 41448907
SGTC_374 0880-0231 82.3 µM 0.307363354887538 0.384752726088991 no 1276 0.379283408797899 1832 6833587
SGTC_2197 6588183 93.1375 µM 0.306061869369664 0.385256842180136 no 1277 0.379778769746907 1806 884136
SGTC_2082 5219693 150 µM 0.305357157824982 0.385529885441286 no 1278 0.380047073798229 1717 2834649
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.304809193545677 0.385742235578486 no 1279 0.380255739547192 1734 4174840
SGTC_554 4483-2211 187 µM 0.304738421507409 0.385769664047278 no 1280 0.380282692205006 1773 747107
SGTC_2317 5986382 200 µM 0.304328995439739 0.385928352753132 no 1281 0.380438628477592 1881 877883
SGTC_864 0469-0573 172 µM 0.304175761780546 0.385987749219483 no 1282 0.380496994893343 1724 689425
SGTC_933 2914-0560 114 µM 0.303606683519158 0.386208358850509 no 1283 0.380713779547489 1933 463887
SGTC_1821 st053465 65.6 µM 0.30241900069654 0.38666889599675 no 1284 0.381166335995399 1765 675086
SGTC_321 4534-3890 65.3 µM 0.301970482112965 0.386842855601262 no 1285 0.38133728251281 1893 699746
SGTC_160 3453-0671 289.699 µM 0.300651510151627 0.387354555411705 no 1286 0.381840124076456 1731 5322268
SGTC_2229 7354935 190 µM 0.298250382206701 0.388286583478437 no 1287 0.382756035532698 1856 318112
SGTC_3211 9128781 49.47 µM 0.29708708038591 0.388738365551964 no 1288 0.38320001384569 1697 17194361
SGTC_1578 josamycin 24.2 µM 0.294816502360705 0.389620604596191 no 1289 0.384067029692274 1722 5282165 A P450 substrate.
SGTC_3176 9106582 49.47 µM 0.294708684917749 0.389662511535312 no 1290 0.384108214046273 1901 17018027
SGTC_1670 st016595 4.04 µM 0.294692402075833 0.389668840530596 no 1291 0.384114433917303 1873 597879
SGTC_3024 9090631 49.47 µM 0.294135843331858 0.38988518752656 no 1292 0.38432705132488 1935 25236383
SGTC_1156 4092-0367 4.88 µM 0.293801459826666 0.390015186384193 no 1293 0.384454809757018 1806 1357585
SGTC_1186 1319-0216 26 µM 0.293756303851247 0.390032742694539 no 1294 0.38447206353388 1946 4565136
SGTC_2247 cerulenin 830 nM 0.29305909625783 0.390303840315708 no 1295 0.384738490621552 1874 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1570 verbenone 133 µM 0.291371248616577 0.390960352572533 no 1296 0.385383700667162 1931 29025 A natural terpanoid with antifungal properties.
SGTC_525 k781-2675 26.7 µM 0.290130638684067 0.391443103725035 no 1297 0.38585814854769 1819 3651118 YDL195W SEC31
SGTC_148 3253-0744 288.01 µM 0.289072828448518 0.39185485525553 no 1298 0.386262823062512 1745 6893655
SGTC_197 4544-0043 41.561 µM 0.287080241187962 0.392630796496616 no 1299 0.387025440470522 1810 896523
SGTC_3030 9087619 49.47 µM 0.286859629372217 0.392716732119553 no 1300 0.387109901501852 1764 25236973
SGTC_227 fluconazole 33.516 µM 0.285955288580274 0.393069057487759 no 1301 0.387456183369857 1768 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2824 7998404 51.95 µM 0.285467748626497 0.393259036290501 no 1302 0.387642904863021 1827 837851
SGTC_3097 9117246 49.47 µM 0.285361871774601 0.393300296491064 no 1303 0.387683457763383 1772 16423892
SGTC_107 0358-0022 2.6945 µM 0.285043105106691 0.393424527069477 no 1304 0.387805559013531 1894 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2125 5246583 200 µM 0.284224774747648 0.393743498570844 no 1305 0.388119065270484 1959 835267
SGTC_1688 st021091 57.6 µM 0.283641874500188 0.393970746847988 no 1306 0.388342421615758 1938 3656366
SGTC_1728 st035614 33.7865 µM 0.283064309867293 0.394195950607125 no 1307 0.388563769880818 1820 15945546
SGTC_2773 thioridazine 9.09 µM 0.28116651602098 0.394936186311809 no 1308 0.389291342731596 1884 5452 An antipsychotic.
SGTC_2797 7859098 81.82 µM 0.280240724796714 0.395297429623694 no 1309 0.389646412010441 1784 972681
SGTC_790 1575-0012 79.1 µM 0.279194625641866 0.395705725321369 no 1310 0.390047733919218 1936 378741 YLR208W SEC13
SGTC_472 calcifediol 10 µM 0.279050835850139 0.395761855875693 no 1311 0.390102906117383 1835 5283731 A vitamin D metabolite.
SGTC_2963 9082507 9 µM 0.278684286018684 0.395904954011225 no 1312 0.390243561440563 1845 16459611
SGTC_2362 9071156 126 µM 0.278374365007303 0.396025955653523 no 1313 0.390362497928229 1877 653133
SGTC_1019 4262-0212 3.4 µM 0.278325948503 0.396044859686618 no 1314 0.390381079360468 1956 4677213
SGTC_780 0109-0199 192 µM 0.274870396286529 0.397394695236972 no 1315 0.391707905870598 1949 610414
SGTC_2976 9009005 19.48 µM 0.274689189369332 0.397465513811176 no 1316 0.391777518712855 1972 2993148
SGTC_1490 4089-0339 670 nM 0.274291362674087 0.397621002726883 no 1317 0.391930360830265 1929 742542
SGTC_1998 st075797 76.8 µM 0.273264560058411 0.398022399394537 no 1318 0.392324927938926 1938 24208315
SGTC_3163 9099914 49.47 µM 0.272650498645432 0.398262499291743 no 1319 0.392560944857216 1904 16268368
SGTC_1811 st050069 61.5 µM 0.272354018485212 0.39837843774037 no 1320 0.392674912323693 1975 3877702
SGTC_3080 9117754 49.47 µM 0.271827485791598 0.398584360247405 no 1321 0.392877335045535 1933 9550191
SGTC_2815 7968870 71.43 µM 0.270609880043227 0.399060663679855 no 1322 0.393345548050294 1786 2977326 YHR190W ERG9
SGTC_1305 1181-0477 144 µM 0.270317780211789 0.399174949775895 no 1323 0.393457893865951 1939 6252086
SGTC_1927 st060202 13.8 µM 0.269961998898241 0.399314163369296 no 1324 0.393594744481883 1965 688887
SGTC_2556 citropten 84.59 µM 0.269402540259913 0.399533099711602 no 1325 0.393809965779567 1728 2775 A potential DNA crosslinker.
SGTC_2657 nystatin 74.44 µM 0.269364381989591 0.399548033570752 no 1326 0.393824646282183 1884 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2158 5657123 3.6195 µM 0.269325429668257 0.399563278346255 no 1327 0.393839632433002 1915 2858827
SGTC_3249 9135183 49.47 µM 0.268871512770536 0.399740939149932 no 1328 0.394014279748756 1877 4902779
SGTC_1986 st071812 45 µM 0.268579355873593 0.399855298880805 no 1329 0.394126700187494 1847 11838594
SGTC_1809 st050081 57.6 µM 0.268119583309854 0.400035286239178 no 1330 0.394303636115835 1909 5036894
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.267443249259363 0.400300089602188 no 1331 0.394563951813743 1712 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1625 st003711 30.1 µM 0.265155987066968 0.40119595455578 no 1332 0.395444649442267 1916 24207034 YER133W GLC7
SGTC_1612 st002233 45.4 µM 0.264997847458629 0.401257913255009 no 1333 0.395505560018169 1865 1035021
SGTC_870 0573-2213 57.6 µM 0.263631733210955 0.401793256587331 no 1334 0.396031851871741 1818 3916321
SGTC_1844 rapamycin 4 nM 0.262326743129147 0.402304819176094 no 1335 0.396534772861864 1850 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_282 k297-0036 65.7 µM 0.262027724493105 0.402422059565569 no 1336 0.396650033837625 1894 5061378
SGTC_2386 9075165 157.42 µM 0.26105303447932 0.402804280700898 no 1337 0.397025804580387 1864 16452277
SGTC_1148 3909-7663 27.7 µM 0.260702613554657 0.402941719714124 no 1338 0.397160925207855 1948 4084526
SGTC_1174 0739-0097 51.1 µM 0.260003992240017 0.403215762595899 no 1339 0.397430347058458 1850 728447
SGTC_666 0272-0154 136 µM 0.259987325204741 0.403222301028482 no 1340 0.397436775264034 1875 6870312
SGTC_2018 5133068 143 µM 0.258055888256015 0.403980181270027 no 1341 0.398181887428444 1833 785362
SGTC_1919 st067113 52.3 µM 0.256747216774548 0.404493898488855 no 1342 0.398686959626685 1829 1268243
SGTC_1200 1643-0193 18.4 µM 0.256422288952461 0.404621474022266 no 1343 0.398812389480274 1965 5403974
SGTC_2580 diallyl disulphide 81.36 µM 0.256341329678773 0.404653262421855 no 1344 0.398843643308901 1843 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1596 piperlongumine 63 µM 0.255780062331451 0.404873659542677 no 1345 0.399060334934239 1981 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3226 9131256 49.47 µM 0.255536654394085 0.404969249776019 no 1346 0.399154318473885 1881 17178073
SGTC_858 0438-0351 2.77 µM 0.255312614822873 0.405057238750591 no 1347 0.399240828756956 1825 2799119
SGTC_272 doxorubicin 8.13 µM 0.254836940966964 0.405244070115688 no 1348 0.399424521103683 1946 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1336 1486-0901 104 µM 0.254587945373749 0.405341877222908 no 1349 0.399520685332664 1884 5006114
SGTC_2355 9061122 103.12 µM 0.254102343789781 0.405532641721281 no 1350 0.399708246352752 1947 5302957
SGTC_2864 9034755 47.6 µM 0.25269477268321 0.406085720833797 no 1351 0.400252043808422 2019 4930451
SGTC_2551 apiole 73.87 µM 0.252632958922237 0.406110013716667 no 1352 0.40027592922198 1918 10659 A possible DNA adduct former.
SGTC_1806 st050005 60.3 µM 0.25227095883595 0.406252287443001 no 1353 0.400415816916138 1809 5194765
SGTC_32 0928-0142 34.1 µM 0.252083870879281 0.406325821838933 no 1354 0.400488118324178 1952 2244242
SGTC_1142 3253-1408 9.78 µM 0.251810180032381 0.406433401209184 no 1355 0.400593894148046 1979 256655
SGTC_2981 9013952 38.96 µM 0.251399200189445 0.406594957882995 no 1356 0.400752743005726 1733 2996344
SGTC_2145 5634607 200 µM 0.250825425577291 0.406820535966486 no 1357 0.400974541528463 1810 308662
SGTC_2850 9015429 58.44 µM 0.248803041590602 0.407615877346831 no 1358 0.401756569115379 1818 6457570
SGTC_1831 st055328 12 µM 0.247922968027302 0.407962102343718 no 1359 0.402097004330687 1971 1103068
SGTC_3273 9137859 49.47 µM 0.247882241930813 0.407978125920027 no 1360 0.402112760038403 2003 2377234
SGTC_70 0141-0289 43.283 µM 0.247007078841467 0.408322493699006 no 1361 0.402451372835684 1910 352408
SGTC_176 1486-1328 72.834 µM 0.246092729519098 0.408682356500952 no 1362 0.402805225525359 1824 22310231
SGTC_2388 9080168 200 µM 0.245902968389953 0.408757050932953 no 1363 0.402878672966266 1794 15943073
SGTC_732 3970-1727 52.7 µM 0.245798199689202 0.4087982917715 no 1364 0.402919225379115 1996 1275699
SGTC_1548 st061468 90.8 µM 0.245240688577496 0.409017765754156 no 1365 0.403135036587524 1976 390799
SGTC_1429 4049-0205 9.46 µM 0.24474410351292 0.409213279158634 no 1366 0.403327288319503 1928 22774478
SGTC_360 0957-0399 1.01 µM 0.243993043383767 0.409509026325043 no 1367 0.403618103852477 1955 6752301 YPR165W RHO1
SGTC_314 1671-0008 2.74 µM 0.243988015611273 0.409511006299602 no 1368 0.403620050819559 1909 3913060
SGTC_489 paxilline 115 µM 0.243397954522451 0.409743392803849 no 1369 0.403848564113903 1848 105008 A toxic potassium channel blocker.
SGTC_2310 7668677 200 µM 0.243108781822054 0.409857290617137 no 1370 0.403960564178922 1904 2197143
SGTC_2021 4019055 173 µM 0.242856634579678 0.409956611247357 no 1371 0.404058230265229 1913 44827708 YER133W GLC7
SGTC_147 4466-0538 29.23 µM 0.242812850773371 0.409973858248266 no 1372 0.404075189985564 1891 6742687 YHR072W ERG7
SGTC_3223 9129970 49.47 µM 0.241713790867637 0.410406848965779 no 1373 0.404500971408691 1885 17248386
SGTC_2072 5231554 129 µM 0.23986912421774 0.411133827631526 no 1374 0.405215858726503 2050 789545
SGTC_3241 9133421 49.47 µM 0.235109974057426 0.413010801259035 no 1375 0.407061688739499 1973 17018221
SGTC_394 menadione 8.33 µM 0.234124721716598 0.413399627584813 no 1376 0.407444077034176 2004 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1127 asiatic acid 681.4 nM 0.23328805659654 0.413729881205797 no 1377 0.40776886611708 1796 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_83 0170-0301 39.027 µM 0.23290950660388 0.413879324863351 no 1378 0.407915838116032 1978 3089716
SGTC_297 0986-0032 24 µM 0.232164930927279 0.414173304216778 no 1379 0.40820495734511 1894 2847425
SGTC_2160 5660466 132.927 µM 0.23120954754169 0.414550586791477 no 1380 0.408576006539479 2015 2859134
SGTC_2433 5607874 27.82 µM 0.230655770974327 0.414769310248395 no 1381 0.408791118320669 1862 2252428
SGTC_847 0342-0274 5.54 µM 0.230111100272293 0.414984462967182 no 1382 0.409002719777963 2007 18097
SGTC_1130 3454-2858 15.9 µM 0.229442539443349 0.415248588913755 no 1383 0.409262488093916 1817 715628 YIL048W NEO1
SGTC_2408 sulbentine 18.36 µM 0.228741540144014 0.415525571348538 no 1384 0.409534903125168 1922 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1695 st026914 34.495 µM 0.227769735979028 0.415909624999879 no 1385 0.409912627748019 1879 3289191
SGTC_370 0180-0345 38.7 µM 0.227437611815952 0.416040897757392 no 1386 0.410041738248481 1872 3989527
SGTC_209 4077-0173 175.592 µM 0.225482919584077 0.416813683215074 no 1387 0.410801805732169 1929 15993494
SGTC_1278 0874-0585 172 µM 0.225051229445489 0.41698439489869 no 1388 0.41096971048834 1946 766306
SGTC_443 clozapine 122 µM 0.224964532357947 0.417018681114042 no 1389 0.411003433062994 2043 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_812 4251-0442 148 µM 0.224710674798743 0.41711907813747 no 1390 0.411102179844355 2032 5723007
SGTC_1344 1488-0097 29.1 µM 0.22395423427436 0.417418271536653 no 1391 0.411396457235484 1929 747966
SGTC_1315 1237-0019 3.69 µM 0.223485492355031 0.417603696093645 no 1392 0.41157883652153 2012 825140
SGTC_2401 5128683 200 µM 0.222796296624267 0.417876360858088 no 1393 0.411847025219257 1840 708373
SGTC_151 3013-0144 2.285 µM 0.222532242707718 0.417980838309808 no 1394 0.4119497881906 2015 906558 YHR107C CDC12
SGTC_2763 lisinopril 49.32 µM 0.221283941599497 0.418474828255033 no 1395 0.412435676410298 2052 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1349 flufenamic acid 69 µM 0.220606213586642 0.418743079340041 no 1396 0.412699531257677 1904 3371 A non-steroidal anti-inflammatory.
SGTC_2071 5230951 39.92 µM 0.220595258388668 0.418747415820522 no 1397 0.412703796688413 2021 1799272
SGTC_567 1080-0542 68.4 µM 0.219613296566788 0.419136153383321 no 1398 0.413086167524099 2024 5950415
SGTC_708 3448-5400 146 µM 0.217344177689239 0.420034750153222 no 1399 0.413970065512871 2029 3462195
SGTC_1939 st074455 53.6 µM 0.216632658185287 0.420316606039442 no 1400 0.414247316251272 2055 1644229
SGTC_1950 st077106 7.18 µM 0.21646831000933 0.420381715481956 no 1401 0.414311362253576 1871 13831864
SGTC_203 k066-0004 30.888 µM 0.216032180872846 0.420554506325435 no 1402 0.414481331541083 2063 6795412
SGTC_1011 4112-3381 17.4 µM 0.215884433034052 0.420613046299858 no 1403 0.414538915814501 1953 2877139
SGTC_3070 9117005 49.47 µM 0.215350771893269 0.420824505696272 no 1404 0.414746923920471 2002 8779016
SGTC_638 3970-0837 4.09 µM 0.214038051635557 0.421344758772039 no 1405 0.41525869189566 1883 4118451 YLR208W SEC13
SGTC_3077 9117319 49.47 µM 0.213690569588607 0.421482494768407 no 1406 0.415394182932661 2004 17154678
SGTC_3222 9128301 49.47 µM 0.213421280359976 0.421589243065258 no 1407 0.415499191758132 1910 4911358
SGTC_1399 3562-5772 25 µM 0.212243188008398 0.422056315477523 no 1408 0.415958657502718 1940 23847490
SGTC_1401 3807-4679 7.6 µM 0.211173833556704 0.422480372071034 no 1409 0.416375814066367 1928 3291456
SGTC_80 0159-0065 512.242 µM 0.210703094151818 0.422667074096171 no 1410 0.416559480013085 2046 1548079
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.210211397947832 0.422862106440056 no 1411 0.416751342017222 1924 2333 A French combination drug.
SGTC_2234 tolnaftate 200 µM 0.2093567968583 0.423201130742813 no 1412 0.417084858254631 2031 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1094 duloxetine 25.4 µM 0.209245418535642 0.423245319245805 no 1413 0.417128329109384 1939 60834 A selective serotonin reuptake inhibitor.
SGTC_1962 st076595 64.5 µM 0.209212244741829 0.423258480883005 no 1414 0.4171412770058 1920 279619
SGTC_379 3970-0972 5.9 µM 0.208323879403212 0.423610969885071 no 1415 0.417488043788915 1958 2898042 YBL034C STU1
SGTC_1129 3453-1384 223 µM 0.205822802788192 0.424603684118132 no 1416 0.418464664244572 1958 1084452
SGTC_2087 5276107 200 µM 0.201140015990049 0.426463633072353 no 1417 0.420294546550991 1965 144405
SGTC_991 3996-0057 64.7 µM 0.201066468117248 0.426492858601939 no 1418 0.420323300546574 1957 715343
SGTC_1715 st032160 10.2275 µM 0.200055636195985 0.426894571117232 no 1419 0.42071853455399 2031 5289825
SGTC_2779 methotrexate 400 µM 0.198744255313611 0.427415837090173 no 1420 0.421231401885406 2059 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2658 polymyxin b sulfate 77.05 µM 0.198117886578437 0.427664859657701 no 1421 0.421476415367417 1959 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2023 5144124 124 µM 0.195512973965012 0.428700790953918 no 1422 0.422495690955433 1947 2830192
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.195185218923223 0.428831168744455 no 1423 0.422623975055132 1984 5393153
SGTC_2462 5162487 171.77 µM 0.194899118564242 0.428944983053342 no 1424 0.42273596212248 2079 2259986
SGTC_2464 5717415 7.67 µM 0.19487605092739 0.428954159905938 no 1425 0.42274499166329 1872 5285744
SGTC_1294 1000-1494 117 µM 0.193958546673954 0.429319195932156 no 1426 0.423104170208698 1913 712797 YDL207W GLE1
SGTC_3322 9139058 2.11 µM 0.192126978606383 0.430048079663333 no 1427 0.42382137134392 2028 4908926 YPR165W RHO1
SGTC_872 0588-0139 234 µM 0.18999758696699 0.430895783726686 no 1428 0.424655510706163 2038 2047100
SGTC_284 0988-0104 32.6 µM 0.189803717352884 0.430972978482081 no 1429 0.424731471411939 2061 4666532
SGTC_880 0833-0487 87.2 µM 0.187320836500488 0.431961840964287 no 1430 0.42570454348448 1921 76075
SGTC_192 3455-0609 60.9 µM 0.186780882090024 0.432176946476211 no 1431 0.425916218500247 2004 3769639
SGTC_1306 1185-0270 9.02 µM 0.186407870865513 0.432325557380313 no 1432 0.426062460274813 2065 1548076
SGTC_1976 st070609 63.5 µM 0.186027939557235 0.4324769351488 no 1433 0.426211425572229 2061 682556
SGTC_3326 9140064 16.379 µM 0.185012251569995 0.432881668966213 no 1434 0.426609713051457 1938 1868434
SGTC_663 1486-0733 13.9 µM 0.182885526049749 0.433729359329756 no 1435 0.427443919948225 1980 722445 YPR165W RHO1
SGTC_1275 0867-0008 21.1 µM 0.182403227408811 0.433921641035215 no 1436 0.427633146594348 2003 3422836
SGTC_704 1310-0270 142 µM 0.180684698748572 0.434606906880974 no 1437 0.428307534866275 1938 5718033
SGTC_1043 0916-0009 19.3 µM 0.176975076897596 0.436086791363186 no 1438 0.42976398315329 2158 3101130
SGTC_47 0149-0135 24.25 µM 0.176753437356283 0.436175238873207 no 1439 0.429851032342889 1890 5239155
SGTC_1822 st052468 42 µM 0.17649844708832 0.436276999277429 no 1440 0.429951184287812 2004 2873678
SGTC_743 1275-0778 158 µM 0.17504351236366 0.436857708778461 no 1441 0.430522721719572 2089 2849257 YMR203W TOM40
SGTC_2104 5389443 200 µM 0.173883568588586 0.437320775816141 no 1442 0.430978483135599 2065 2244536
SGTC_970 1315-0089 19.5 µM 0.173680761411319 0.437401748335692 no 1443 0.431058178945152 2070 6811083 YLR033W RSC58
SGTC_2674 ligustilide 100 µM 0.172704692326356 0.437791488975181 no 1444 0.431441777638091 2033 5319022 A signalling regulator.
SGTC_1575 cyproterone acetate 48 µM 0.170158474916531 0.438808466976173 no 1445 0.432442753814104 1953 9880 An androgen receptor antagonist and liver toxin.
SGTC_2910 7948405 25.97 µM 0.169206818775482 0.439188669558865 no 1446 0.432816983260743 2099 2971328
SGTC_2495 cafestol 54.53 µM 0.168799215859708 0.439351530939924 no 1447 0.432977287564113 2040 16667697 An anti-infammatory.
SGTC_2272 7805186 180 µM 0.168331501094111 0.439538423193882 no 1448 0.433161246572593 2144 2956062 YPR165W RHO1
SGTC_2775 cyproheptadine 69.59 µM 0.168246132987394 0.439572536546366 no 1449 0.433194824652721 2123 2913 A selective serotonin reuptake inhibitor.
SGTC_1870 st057514 26.5 µM 0.16802797719302 0.439659714296511 no 1450 0.433280634681986 2002 5393161
SGTC_1497 4476-2978 41.3 µM 0.167207070554331 0.439987784916484 no 1451 0.433603560621906 2065 1528379
SGTC_2058 5236698 133 µM 0.16636448067966 0.440324563972722 no 1452 0.433935062350232 2001 766665
SGTC_283 0987-0079 11.7 µM 0.165171791258978 0.440801349863526 no 1453 0.434404383798853 2102 411556
SGTC_983 1491-0821 12.2 µM 0.164984411692756 0.440876263967144 no 1454 0.434478125790474 2103 46495113
SGTC_1193 1488-0126 41.5 µM 0.163112262745995 0.441624862390548 no 1455 0.435215022413926 2054 1384710
SGTC_1759 st043059 70 µM 0.162612602327874 0.441824692229045 no 1456 0.43541173192445 1970 669426
SGTC_171 k064-0041 9.68 µM 0.159888124853042 0.442914555214207 no 1457 0.436484601583684 1976 53325
SGTC_463 ikarugamyin 104 µM 0.159590009070252 0.443033835779243 no 1458 0.436602024856424 2130 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2688 kanamycin b 96.69 µM 0.15958134043677 0.443037304305914 no 1459 0.436605439382946 2031 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_3205 9113483 49.47 µM 0.1594136204534 0.443104413923909 no 1460 0.436671504281193 2103 17018033
SGTC_1617 st002906 78 µM 0.159377134909759 0.443119013061773 no 1461 0.436685876170123 1990 5150859
SGTC_2342 7990637 118.86 µM 0.159278960708516 0.443158296365333 no 1462 0.436724548030649 2026 2033102 YER133W GLC7
SGTC_2534 helenine 20.12 µM 0.158393510443662 0.443512624537803 no 1463 0.43707336357266 2020 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_569 4130-2812 160 µM 0.158173783791938 0.443600558947547 no 1464 0.43715993059079 2157 743552
SGTC_393 acivicin 6.25 µM 0.157660176244433 0.443806115054806 no 1465 0.437362291345175 2026 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_972 1319-0219 195 µM 0.156663230071556 0.444205156144501 no 1466 0.437755133663354 2001 23903702
SGTC_3112 9123419 49.47 µM 0.156371029650887 0.444322124023104 no 1467 0.437870285617474 2172 17015854
SGTC_3225 9130819 49.47 µM 0.155577869352065 0.44463965064539 no 1468 0.438182885102392 2107 4547121
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.154307226997521 0.445148402084337 no 1469 0.438683749623259 2045 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1029 k015-0030 64.7 µM 0.152200286510223 0.445992196973288 no 1470 0.439514483997109 2046 2208316
SGTC_3151 9099821 49.47 µM 0.15178040829299 0.446160380626643 no 1471 0.439680067503355 2021 17174189
SGTC_2712 st079126 47.7 µM 0.151663803015376 0.446207088988558 no 1472 0.43972605392646 2065 3152970
SGTC_3287 9117173 37.0625 µM 0.151340683712263 0.446336524192516 no 1473 0.439853488949589 2165 2789709
SGTC_1145 3546-0597 10.2 µM 0.15015701843659 0.44681072583468 no 1474 0.440320367831636 2048 875334
SGTC_937 3122-0005 46.7 µM 0.1500064499467 0.446871052261392 no 1475 0.44037976326033 2141 759535
SGTC_2294 7971431 200 µM 0.149238546148604 0.447178737934908 no 1476 0.440682702561485 2097 5741572
SGTC_2443 5493264 126.67 µM 0.148761903822752 0.44736973621482 no 1477 0.440870756211145 2106 5340055
SGTC_382 3229-0966 23.2 µM 0.147674657749106 0.447805458886479 no 1478 0.441299766254374 2140 5722370
SGTC_211 3455-0679 143.504 µM 0.147080593410151 0.448043561627303 no 1479 0.441534203747468 2042 748649
SGTC_784 4579-0127 173 µM 0.146057799594802 0.448453544221547 no 1480 0.441937880062364 2134 1948547
SGTC_849 0386-0493 241 µM 0.145544930058667 0.44865914656908 no 1481 0.442140322165328 2050 726119
SGTC_2264 7948757 110.76 µM 0.144417475068942 0.449111176177449 no 1482 0.442585409175066 1991 2971411
SGTC_956 1185-0240 191 µM 0.144196857232382 0.449199636052596 no 1483 0.442672511288152 2062 1416193
SGTC_1787 fluconazole 80 µM 0.144047540361803 0.449259508219327 no 1484 0.442731464644319 2072 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1297 1068-0111 14.1 µM 0.143624679123383 0.449429070800151 no 1485 0.442898425790865 2037 767057
SGTC_2457 5731572 11.68 µM 0.143207186979072 0.449596489494941 no 1486 0.443063276970096 2164 2865357
SGTC_2184 6075246 200 µM 0.142423169687498 0.449910912811138 no 1487 0.443372881084117 2079 2267320
SGTC_260 nsc-65238 3.989 µM 0.142390024901702 0.449924205933423 no 1488 0.443385970540637 2135 3246252
SGTC_526 4469-0568 170 µM 0.142052646046902 0.450059519049471 no 1489 0.443519210872648 1980 2901964
SGTC_445 e6 berbamine 66 µM 0.141323533203389 0.450351965400281 no 1490 0.443807179689643 2064 6610268 A calcium/calmodulin antagonist.
SGTC_537 1334-0398 209 µM 0.139778639381552 0.450971709483032 no 1491 0.444417445446105 2181 5846986
SGTC_331 k048-0133 24.5 µM 0.139544969658819 0.451065458038663 no 1492 0.444509761442182 2048 6813582
SGTC_1316 1272-0050 65.9 µM 0.138080327613619 0.451653136044578 no 1493 0.445088466562944 2122 7340392
SGTC_2507 purpurin 79.67 µM 0.137284033817527 0.451972688252208 no 1494 0.445403145055091 1993 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2626 ethyl orsellinate 100 µM 0.137279279132924 0.451974596397858 no 1495 0.445405024109553 2075 75653 A natural product.
SGTC_1077 5-fluorocytosine 377 nM 0.13633538106476 0.45235342261616 no 1496 0.445778077478337 2097 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1357 1503-1303 39.5 µM 0.136033921757761 0.452474420142762 no 1497 0.445897232264505 2125 292895
SGTC_2285 7945142 200 µM 0.134611789871983 0.453045284350967 no 1498 0.446459409743609 2079 2970608
SGTC_776 4476-4378 112 µM 0.133933815351831 0.453317467317731 no 1499 0.446727455195185 2005 2892008
SGTC_2795 7780010 54.55 µM 0.133258478599762 0.453588613117286 no 1500 0.446994481972065 2079 953673
SGTC_162 k030-0015 37.8 µM 0.133010987360153 0.453687985575362 no 1501 0.447092345527944 2147 1809920 YMR134W ERG29
SGTC_381 3461-2219 42.7 µM 0.131896373965948 0.454135559980653 no 1502 0.447533128364166 2151 2883159
SGTC_721 1187-1332 279 µM 0.131850605213184 0.454153939729556 no 1503 0.44755122937461 2123 25730
SGTC_1194 1488-0194 225 µM 0.131555802149169 0.454272328664582 no 1504 0.447667823180538 2065 1391452
SGTC_1636 st007707 68.9 µM 0.130658695146961 0.454632619687805 no 1505 0.448022654323409 2148 403051
SGTC_2233 sulbentine 40.3845 µM 0.127543145425855 0.455884157127755 no 1506 0.449255263442072 2136 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3117 9124945 49.47 µM 0.126830827631404 0.456170361962399 no 1507 0.449537147919805 1982 17592065
SGTC_424 splitomicin 100 mM 0.126056418839514 0.456481540369488 no 1508 0.44984363246676 1978 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_303 1348-1668 34.2 µM 0.125671451744343 0.456636240509048 no 1509 0.44999600043807 2096 5380509
SGTC_3290 9121031 71.43 µM 0.125377601965933 0.456754329316064 no 1510 0.450112309612092 2068 17014854
SGTC_594 1487-1584 10.8 µM 0.1244537488628 0.457125621096249 no 1511 0.450478009328075 2078 5013332
SGTC_3127 9126946 49.47 µM 0.124301361144092 0.457186868536327 no 1512 0.450538334811903 2017 27243249
SGTC_908 3448-7491 47.7 µM 0.122582263781321 0.457877875634323 no 1513 0.45121894997986 2106 1203031
SGTC_261 5-fluorouridine 15.376 µM 0.121403290574729 0.458351848566887 no 1514 0.451685805329391 2176 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_709 3807-1509 243 µM 0.119749842491744 0.459016670366053 no 1515 0.452340657904422 2193 1886677 YPL242C IQG1
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.119741891706965 0.459019867512353 no 1516 0.452343807148877 2023 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2671 danthron 100 µM 0.114705774147881 0.46104550022528 no 1517 0.454339168516708 2121 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2228 7354201 200 µM 0.113595418175556 0.461492246700324 no 1518 0.454779259803544 2151 753451
SGTC_986 1493-0483 84 µM 0.11314794212609 0.461672300342911 no 1519 0.454956633343698 2199 40079
SGTC_92 0063-0024 660.874 µM 0.112853614754121 0.461790734911752 no 1520 0.455073305688366 2229 3594437
SGTC_863 0466-0191 129 µM 0.112504700431845 0.461931139144815 no 1521 0.455211621500277 2213 765160 YPR165W RHO1
SGTC_428 3448-4153 16.5 µM 0.112054243671531 0.462112411391637 no 1522 0.45539019855897 1997 3834874
SGTC_888 0916-0002 6.97 µM 0.111750826885644 0.462234516433784 no 1523 0.455510488832223 2189 2802138 YIL048W NEO1
SGTC_17 0960-0276 49.807 µM 0.11113334123899 0.462483024248653 no 1524 0.45575530500311 2212 6821114
SGTC_2526 patulin 37.61 µM 0.110192503552496 0.462861693590644 no 1525 0.4561283536842 2141 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_420 mitomycin C 81.9 mM 0.109992358511136 0.462942252530545 no 1526 0.456207717584125 2115 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1053 3366-3204 134 µM 0.109165044902609 0.463275264665034 no 1527 0.456535792350303 2104 3632071 YPR165W RHO1
SGTC_2930 9013230 14.89 µM 0.10895019311094 0.463361751510588 no 1528 0.456620997607158 2177 2995857
SGTC_2490 carminic acid 95.39 µM 0.108691216943537 0.463466002566903 no 1529 0.456723704222678 2211 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.1080454101169 0.463725983517581 no 1530 0.456979835478983 2167 364106
SGTC_11 0438-0307 1.3 µM 0.107469708914007 0.463957755273875 no 1531 0.457208177452352 2231 4011476
SGTC_734 2023-0417 80 µM 0.106109416069176 0.464505444520809 no 1532 0.457747770191298 2174 3935732
SGTC_737 1950-0117 57.9 µM 0.105499945030478 0.464750855278825 no 1533 0.457989556803057 2236 5393513
SGTC_1146 3579-1023 7 µM 0.105454529404582 0.464769142958393 no 1534 0.458007574509605 2209 X1146
SGTC_2472 5377652 49.4 µM 0.104695396689365 0.465074836750357 no 1535 0.458308757399118 2067 1610903
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.104559325334597 0.465129633263978 no 1536 0.45836274570359 2238 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_826 1683-5028 118 µM 0.103905440214493 0.465392964789898 no 1537 0.458622194906365 2124 722377
SGTC_3067 9117431 49.47 µM 0.103691321642553 0.465479197563803 no 1538 0.458707156927718 2106 17150885
SGTC_944 3370-0224 231 µM 0.103507543852549 0.465553212373928 no 1539 0.458780081263607 2129 4580514
SGTC_1540 guanosine 70.6 µM 0.102835999801107 0.465823680661185 no 1540 0.459046566503303 2197 6802 Guanosine is a purine nucleoside
SGTC_600 1495-0418 41.6 µM 0.102671250721125 0.465890036731293 no 1541 0.459111945816795 2153 5377768
SGTC_1748 st037455 53.6035 µM 0.100673371203458 0.466694798609989 no 1542 0.459904875327843 2155 580690
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.100488616089893 0.466769226379327 no 1543 0.459978210067525 2103 688667
SGTC_2528 xanthyletin 44.79 µM 0.100058475321789 0.466942511157155 no 1544 0.460148950862902 2132 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_459 nigericin 15.3 µM 0.10003160903514 0.466953334609455 no 1545 0.460159615455781 2143 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_342 k048-0088 23.3 µM 0.0994382406685875 0.46719238741495 no 1546 0.460395160772419 2187 6820570
SGTC_500 h-89 112 µM 0.0993789850624827 0.467216260621111 no 1547 0.46041868382318 2237 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_44 0929-0055 61.211 µM 0.0993265690239253 0.467237378365096 no 1548 0.460439491845553 2155 1379590
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.0987165525653251 0.467483152872554 no 1549 0.460681663006987 2212 688798
SGTC_3001 9076041 71.4286 µM 0.0979170586439179 0.467805286256871 no 1550 0.460999077120316 2218 16004211
SGTC_3 0833-0587 95.581 µM 0.0961706806027321 0.468509012762007 no 1551 0.461692508173367 2160 5382644
SGTC_1358 1509-0022 2.48 µM 0.0949160880753216 0.469014628554651 no 1552 0.46219073888801 2156 3258434
SGTC_1554 st069299 38.7 µM 0.0946635020248516 0.469116429823694 no 1553 0.462291054455895 2167 24207999
SGTC_2236 dapsone 200 µM 0.0945281696530076 0.469170974471372 no 1554 0.462344803240044 2252 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3219 9131112 49.47 µM 0.0923247000894789 0.470059146215644 no 1555 0.463220032171681 2259 17612988 YMR079W SEC14
SGTC_1031 k035-0009 16 µM 0.0913112164518178 0.470467710215721 no 1556 0.463622652891538 2234 5180959
SGTC_2856 9022925 19.48 µM 0.0910134768515769 0.470587743421021 no 1557 0.463740941261472 2170 4944862
SGTC_833 3852-0053 558 µM 0.0904092019472605 0.470831364008606 no 1558 0.463981022272454 2202 3123681
SGTC_1085 doxorubicin 7.67 µM 0.0899228583859897 0.471027447111055 no 1559 0.4641742581857 2256 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2607 solasodine 47.35 µM 0.0893658938476745 0.471252011674426 no 1560 0.464395563878103 2154 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_994 3910-0338 138 µM 0.089141143657379 0.471342632115839 no 1561 0.46448486980796 2210 3479481
SGTC_674 0498-0004 451 µM 0.0877920854794163 0.471886610383793 no 1562 0.465020964174537 2119 4231473
SGTC_3171 9103192 49.47 µM 0.0870908356493511 0.472169394854972 no 1563 0.465299654900104 2253 13018434
SGTC_1008 4106-0037 6 µM 0.0862899667963848 0.472492368627753 no 1564 0.465617957031983 2251 2905394
SGTC_196 k015-0023 18.111 µM 0.0855274985943411 0.472799873025891 no 1565 0.465921017422095 2126 5211998
SGTC_996 3970-0799 1.8 µM 0.0837255983783875 0.47352664577679 no 1566 0.46663730201829 2218 6615648 YGL040C HEM2
SGTC_2281 7943571 200 µM 0.0826264670943361 0.473970009350764 no 1567 0.467074277765683 2298 1244024
SGTC_100 0086-0128 49.5915 µM 0.0807450659468115 0.47472899662318 no 1568 0.467822348177909 2181 93297
SGTC_2789 5281112 71.43 µM 0.0806685037730498 0.474759884987808 no 1569 0.467852792752796 2186 765948
SGTC_1165 k072-0275 30.3 µM 0.0797730569483056 0.475121156687361 no 1570 0.468208876727138 2265 6153523 YGL055W OLE1
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0793662040910859 0.475285309920373 no 1571 0.468370674523788 2122 2374 Ca(2+)-ATPase inhibitor.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.0787815264840794 0.475521217580307 no 1572 0.46860319905051 2275 5024745
SGTC_2418 pentamidine 31.67 µM 0.0762963979987544 0.476524020220135 no 1573 0.469591645736826 2281 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3269 9137823 49.47 µM 0.0754850623146125 0.476851444074311 no 1574 0.46991439108625 2140 17682936
SGTC_809 3998-0021 90 µM 0.07515184216856 0.476985923439813 no 1575 0.470046950161682 2279 715485
SGTC_2968 9090663 33.37 µM 0.074866849170339 0.477100941607591 no 1576 0.470160326518374 2140 25236811
SGTC_375 3970-0961 9.27 µM 0.0745719110329024 0.477219975467375 no 1577 0.470277661812848 2208 2898222
SGTC_2565 isoliquiritigenin 100 µM 0.0745662619855381 0.477222255381999 no 1578 0.47027990919964 2044 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2358 9037157 4 µM 0.0737075089456043 0.47756885052008 no 1579 0.470621561884882 2211 2388925
SGTC_2458 5808907 16.39 µM 0.0716614292479356 0.478394721919009 no 1580 0.471435676105175 2281 2731747
SGTC_3034 9090421 49.47 µM 0.070185714776777 0.478990431181787 no 1581 0.472022922120792 2277 17173761
SGTC_2695 st077686 51.995 µM 0.0694781620229007 0.479276069375639 no 1582 0.472304507411086 2217 2876092
SGTC_1781 st038725 66.3 µM 0.0694083279577469 0.479304261883033 no 1583 0.472332300078245 2145 4270275 YIL048W NEO1
SGTC_2953 9074162 66.49 µM 0.0693291076873498 0.479336243793398 no 1584 0.472363828444683 2294 16451992
SGTC_1448 4255-0083 152 µM 0.0681129188724645 0.479827246343202 no 1585 0.472847873234072 2283 5399660
SGTC_764 1951-2361 146 µM 0.0676960291775211 0.479995561093573 no 1586 0.473013805159602 2201 5438930
SGTC_1251 0490-5699 265 µM 0.0673629281503863 0.480130049631536 no 1587 0.473146390587392 2287 3883818
SGTC_534 k292-0788 63.4 µM 0.0667116589589499 0.480393004129412 no 1588 0.473405626241925 2307 4146317
SGTC_2010 4012422 159 µM 0.0651090346665052 0.481040111007461 no 1589 0.474043593537202 2254 952393
SGTC_464 bw-b 70c 158 µM 0.0648888685456017 0.481129013521233 no 1590 0.474131241764761 2280 5353454
SGTC_1880 MG-132 525 µM 0.0648393779160059 0.481148997839624 no 1591 0.474150944178243 2288 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_409 arachidonic acid 100 µM 0.064553286133545 0.481264522640776 no 1592 0.474264839674987 2309 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_3156 9099931 49.47 µM 0.0626794522254588 0.482021221384301 no 1593 0.475010879981646 2236 18111053
SGTC_2719 novobiocin 32.65 µM 0.0623735318735748 0.48214476552858 no 1594 0.475132686206594 2279 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2378 9074213 121.43 µM 0.0619545957931456 0.482313953193071 no 1595 0.475299494903736 2282 657714
SGTC_2329 6138490 200 µM 0.061845276672859 0.482358102330739 no 1596 0.475343023450884 2174 720019
SGTC_414 piperonyl butoxide 100 µM 0.0605845911579811 0.482867252717303 no 1597 0.475845022727246 2258 5794 A potent inhibitor of cytochrome P450.
SGTC_188 3229-0966 278.469 µM 0.0602465416466094 0.483003784842125 no 1598 0.475979639067683 2302 5722370
SGTC_263 alizarin 107.927 µM 0.0596570844314179 0.483241860780415 no 1599 0.476214376242127 2304 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_49 0717-0965 32.132 µM 0.0590989183382962 0.483467304053329 no 1600 0.476436660089369 2257 5889349 YGL099W LSG1
SGTC_2367 9070478 135.38 µM 0.0582734043404612 0.48380073880776 no 1601 0.476765425883639 2292 572802
SGTC_2749 bexarotene 57.39 µM 0.0580480687171555 0.483891756478369 no 1602 0.476855169875221 2232 82146 An retinoic acid receptor inhibitor.
SGTC_2011 4012611 177 µM 0.0573546074147111 0.484171864938507 no 1603 0.477131360739083 2263 2049887
SGTC_194 1486-1323 56.904 µM 0.0572836364593427 0.4842005325399 no 1604 0.477159627580597 2257 5178754
SGTC_1562 morin hydrate 59.1 µM 0.0569892891061064 0.484319430394697 no 1605 0.477276863665222 2254 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_357 1325-0123 420 µM 0.0569614869010716 0.484330660812643 no 1606 0.477287937152356 2291 1098503
SGTC_2269 7935389 174.42 µM 0.0563644970666595 0.484571811768631 no 1607 0.477525719604759 2308 97605
SGTC_585 0kpi-0023 191 µM 0.055967620754436 0.484732131030501 no 1608 0.477683800804464 2298 64601
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.0559111982709421 0.484754923246597 no 1609 0.477706274927959 2242 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1375 2910-0797 186 µM 0.0557102980924279 0.484836078537682 no 1610 0.477786297776904 2260 742508
SGTC_1437 4092-1038 11.6 µM 0.055666028621849 0.484853961641561 no 1611 0.477803931376829 2295 3977136
SGTC_2787 5284540 71.43 µM 0.0544587934521089 0.485341648215144 no 1612 0.478284818952342 2235 736958
SGTC_1079 idarubicin 2.36 µM 0.0523641244853729 0.486187882862057 no 1613 0.479119279696874 2317 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1982 st072467 71.9 µM 0.0521223309230005 0.486285570197173 no 1614 0.479215609822511 2181 3163533
SGTC_3124 9127567 49.47 µM 0.0516075726140362 0.486493541112153 no 1615 0.47942069265464 2314 17592030
SGTC_2238 6671620 73.2395 µM 0.0515139765935693 0.486531355856845 no 1616 0.47945798246378 2324 729941
SGTC_1050 3232-1156 69.3 µM 0.0508872934545197 0.486784552021133 no 1617 0.479707665373199 2242 700529
SGTC_1431 4049-0260 9.09 µM 0.0482458210018056 0.487851832422898 no 1618 0.480760166401838 2311 3854841
SGTC_2487 5918373 44.05 µM 0.0464887688048868 0.488561813669248 no 1619 0.481460342802233 2340 2876279
SGTC_1411 3909-8223 150 µM 0.0454452525175588 0.488983490039585 no 1620 0.481876205966144 2337 X1411
SGTC_814 3342-0569 96 µM 0.0453707595494932 0.489013592513311 no 1621 0.481905893738493 2334 4346283
SGTC_1125 tnp00248 1.32998 µM 0.0451981200642077 0.489083356057514 no 1622 0.481974696346093 2314 24207736
SGTC_3062 9077494 49.47 µM 0.0450732255818685 0.489133826074222 no 1623 0.482024471308326 2275 16459633
SGTC_1942 st076330 65.2 µM 0.0450241463733668 0.489153659091502 no 1624 0.482044031222322 2282 24208414
SGTC_467 ro 31-8220 72.8 µM 0.0444902266275928 0.489369418970374 no 1625 0.48225682114296 2321 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1545 lovastatin 49.4 µM 0.0442287493603155 0.489475084497739 no 1626 0.482361032897409 2303 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1402 3909-7673 35.9 µM 0.0442115500849764 0.489482034919508 no 1627 0.482367887710232 2318 5328014
SGTC_2960 9079389 5.97 µM 0.0440213862206099 0.489558882501158 no 1628 0.482443678325694 2333 16457355
SGTC_225 nsc-122657 1.016 µM 0.0439216767637481 0.489599176487312 no 1629 0.482483418206757 2310 275685
SGTC_82 0054-0107 293.755 µM 0.0436398137987616 0.489713081826694 no 1630 0.482595757545371 2328 3104697
SGTC_3333 9141820 12.094 µM 0.0436368051257434 0.4897142976842 no 1631 0.482596956689935 2238 1939433
SGTC_1833 st055984 71 µM 0.0428877314861865 0.490017014417601 no 1632 0.482895514304367 2245 676288
SGTC_2330 7979373 200 µM 0.0428499390060875 0.490032287323706 no 1633 0.482910577475125 2296 1863007
SGTC_1913 st060213 96.1 µM 0.0425309344041863 0.490161205808109 no 1634 0.483037725982736 2325 688959
SGTC_2971 9092186 9.93 µM 0.0424315623710776 0.490201364975105 no 1635 0.483077333932716 2262 25236400
SGTC_686 1319-0111 510 µM 0.040727603786834 0.490889999967458 no 1636 0.483756527604121 2321 4562600
SGTC_226 1,3-diallylurea 8.28947 mM 0.0401712589616096 0.49111484622133 no 1637 0.483978295576743 2290 74537 YKL182W FAS1
SGTC_3036 9090181 49.47 µM 0.0399572045160284 0.491201356886372 no 1638 0.484063622436851 2333 25236586
SGTC_2702 st077768 96.8 µM 0.0399446051774877 0.491206448954993 no 1639 0.484068644836038 2299 6484119
SGTC_2898 9056270 58.44 µM 0.0394564517905044 0.491403739021992 no 1640 0.484263236448025 2328 19154699
SGTC_3300 9124615 50.48 µM 0.0390542925143185 0.491566275644587 no 1641 0.484423551216808 2309 24824903
SGTC_2932 9016711 44.54 µM 0.0384205732452321 0.491822402344765 no 1642 0.484676179006598 2332 7117328
SGTC_545 4218-0007 221 µM 0.0371864694731033 0.49232119260353 no 1643 0.485168163473842 2306 2840508
SGTC_3159 9100096 49.47 µM 0.0368686757692518 0.492449637913438 no 1644 0.485294857936784 2348 25236875
SGTC_317 4495-0002 170 µM 0.0363867938088527 0.492644405620441 no 1645 0.485486972110541 2232 15991618
SGTC_2165 5727197 32.143 µM 0.0343573321048567 0.493464694915007 no 1646 0.486296103707801 2280 1361712
SGTC_2923 7992654 58.14 µM 0.0339063538963171 0.493646979931747 no 1647 0.486475913213211 2332 2985126
SGTC_2354 9060492 162 µM 0.033712601553268 0.493725294877256 no 1648 0.486553165049495 2326 6471895
SGTC_487 nimodipine 119 µM 0.032080398770818 0.494385042638517 no 1649 0.487203967439538 2354 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1896 st058441 89 µM 0.0316586831919426 0.494555505589319 no 1650 0.487372122196651 2227 688759
SGTC_2921 7974240 10.71 µM 0.0313599252405284 0.494676268062914 no 1651 0.487491250222641 2318 2979074 YDR527W RBA50
SGTC_1475 4092-1048 11.7 µM 0.0303610146499902 0.495080046281701 no 1652 0.48788956815708 2270 2881759
SGTC_2760 etidronate 98.04 µM 0.0303130922575482 0.495099417533053 no 1653 0.487908677630002 2343 3305 A chelator and antioxidant.
SGTC_2667 digitoxin 100 µM 0.030110950371939 0.495181127713699 no 1654 0.487989283778993 2355 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2215 7188065 200 µM 0.0296259219155241 0.495377187664501 no 1655 0.488182695842594 2352 940217
SGTC_2586 curcumin 80 µM 0.0291564643690063 0.49556695454989 no 1656 0.488369901429524 2341 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1066 ketoconazole 628 nM 0.0289698614057352 0.495642384576159 no 1657 0.48844431380762 2338 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2492 derrusnin 100 µM 0.028512374376497 0.495827314011386 no 1658 0.488626749358552 2340 1715307 Part of coumarin class of compounds.
SGTC_738 1315-0003 72.4 µM 0.0283657422610268 0.495886587127892 no 1659 0.488685223457901 2341 6251474
SGTC_1662 st014054 52 µM 0.0278877073114307 0.49607982387301 no 1660 0.488875856388014 2350 2838777
SGTC_1526 st051518 75 µM 0.0269132718878441 0.496473724085032 no 1661 0.489264453958282 2227 673993
SGTC_2651 TUB2.036 5 µM 0.0263265774352776 0.496710887783427 no 1662 0.489498428263564 2342 15992207 YFL037W TUB2
SGTC_377 3970-0964 33.1 µM 0.0255716078359707 0.497016076247584 no 1663 0.489799516163347 2341 16481235
SGTC_3146 9095609 49.47 µM 0.0252854105768275 0.497131768924435 no 1664 0.489913655442452 2349 17173999
SGTC_1030 k029-0042 36.7 µM 0.0248750191413112 0.497297666402445 no 1665 0.490077326452412 2245 6080581
SGTC_2913 7966556 36.57 µM 0.0235374795903908 0.497838359235214 no 1666 0.490610771184363 2365 2976516
SGTC_2455 5377712 9.75 µM 0.0232752574896583 0.497944361539804 no 1667 0.490715354014703 2270 2243908
SGTC_465 cgp-37157 41 µM 0.0228322395521348 0.498123450211803 no 1668 0.490892045639654 2363 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2131 toluylene red 5.2905 µM 0.0228062330235746 0.498133963285046 no 1669 0.490902418042565 2345 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2569 tetrandrine 100 µM 0.0226265960553756 0.498206581109052 no 1670 0.490974064335807 2342 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_184 1494-0393 24.714 µM 0.0211263518536571 0.498813053406917 no 1671 0.491572431922151 2350 3090647
SGTC_113 0099-0221 2.5 µM 0.020623415286891 0.499016365721206 no 1672 0.491773030869544 2359 89219
SGTC_122 0236-0016 402.397 µM 0.0202639048450267 0.499161698125076 no 1673 0.491916424815881 2365 6808838
SGTC_1679 SEC14.276 6.7 µM 0.0198618868080095 0.499324214391534 no 1674 0.492076774532037 2372 1005053 YMR079W SEC14
SGTC_435 c-PAF 6.7 µM 0.0191982985070286 0.49959247097879 no 1675 0.492341457474127 2368 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.0189862338166647 0.499678198499394 no 1676 0.492426043627285 2374 97141
SGTC_3063 1327-0034 4 µM 0.0189444705106395 0.499695081390504 no 1677 0.492442701779716 2354 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2148 5546263 113.568 µM 0.0182165253117919 0.499989354599408 no 1678 0.492733059765761 2369 792097
SGTC_3291 9121177 71.43 µM 0.0181638581492021 0.499989354599408 no 1679 0.492754067447873 2360 17015612
SGTC_792 4534-1957 155 µM 0.017404798806408 0.499682503442146 no 1680 0.493056840421122 2292 1717904
SGTC_496 calpeptin 138 µM 0.0167749076507033 0.499427868900593 no 1681 0.493308093937413 2296 73364 A calpain inhibitor.
SGTC_2628 lathosterol 100 µM 0.0166693060069512 0.499385179281434 no 1682 0.493350217008141 2362 6710616
SGTC_1718 roemerine 11.9335 µM 0.016513443287945 0.499322171561994 no 1683 0.493412388678926 2371 235224 An aporphine alkaloid with mutagenic activity.
SGTC_917 harmaline 728.087 nM 0.0142425857848076 0.498404177003789 no 1684 0.494318222441458 2368 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_327 1273-0057 3.96 µM 0.0138139526610217 0.498230902786152 no 1685 0.494489205491104 2377 3108138
SGTC_1928 4'-methoxychalcone 40.3 µM 0.0105116284140487 0.496895957416519 no 1686 0.495806544215425 2386 641818
SGTC_2227 7312221 64.1025 µM 0.0104331833333386 0.496864246812379 no 1687 0.495837837558764 2372 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3042 9091578 49.47 µM 0.00940445292993723 0.49644839520533 no 1688 0.496248221405836 2378 25236497
SGTC_724 3910-0327 137 µM 0.00849795564701375 0.496081958016965 no 1689 0.496609846998937 2381 2885483
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.00826159662141374 0.495986414150226 no 1690 0.496704137296763 2385 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_623 k072-0108 16.9 µM 0.00735303460552196 0.495619146558446 no 1691 0.49706659004013 2373 5382803
SGTC_1862 st057513 3.81 µM 0.00711530006956465 0.495523047840237 no 1692 0.497161429916143 2394 5393163
SGTC_1819 st053448 58.6 µM 0.00706566799678979 0.495502985248962 no 1693 0.497181229750711 2381 2857616
SGTC_1329 1447-1697 50.6 µM 0.00689690838964779 0.495434768255507 no 1694 0.497248553452499 2358 2840515
SGTC_3091 9116372 49.47 µM 0.00688412704973748 0.495429601713096 no 1695 0.497253652348343 2346 17169793
SGTC_3126 9127922 49.47 µM 0.00663658157446138 0.495329537693238 no 1696 0.497352406447825 2384 45595682
SGTC_229 benomyl 22.8748 µM 0.00596481530643278 0.495057994607764 no 1697 0.497620397090144 2391 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1564 D-Arginine 115 µM 0.00519779925330183 0.494747952216742 no 1698 0.497926387449995 2393 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1132 3456-3614 2.5 µM 0.00405030417143593 0.494284118989549 no 1699 0.498384166835477 2396 3125502
SGTC_2602 kawain 100 µM 0.00333997090503344 0.493996996387613 no 1700 0.498667546868015 2399 5369129
SGTC_1476 4112-3294 3.34 µM 0.00327359652593402 0.49397016746926 no 1701 0.498694026269394 2395 704369
SGTC_2161 5662504 8.5105 µM 0.00247919711856455 0.49364906866049 no 1702 0.499010944461147 2400 2859334
SGTC_3198 9112019 49.47 µM 0.00233647032826601 0.493591378460456 no 1703 0.499067884047236 2398 45595555
SGTC_135 0933-0004 26.348 µM 0.000608443108609482 0.492892920467833 no 1704 0.499757266333734 2398 21230617 YGL099W LSG1
SGTC_479 n-linoleoylglycine 10 µM 0.000233289891203123 0.492741288645492 no 1705 0.499906930799653 2405 6433346 An anti-infammatory.
SGTC_3209 9113616 49.47 µM 0 0.492646996575491 no 1706 0.5 2406 16649353
SGTC_3106 9121286 49.47 µM -0.000979136107772736 0.492251249848954 no 1707 0.499609381270757 2413 15943471
SGTC_3177 9107506 49.47 µM -0.00133001431017538 0.492109433914266 no 1708 0.499469401214565 2408 8897194
SGTC_1645 Cervolide 78 µM -0.00184350450412386 0.491901896202443 no 1709 0.499264548525768 2412 23173 A fragrance.
SGTC_2555 cholic acid 100 µM -0.00255373349744611 0.491614846049169 no 1710 0.498981208842342 2423 6708657 Influences liver metabolism.
SGTC_1051 3253-3903 78 µM -0.00298440112193517 0.491440787099923 no 1711 0.498809397978162 2408 5509239
SGTC_2412 st077135 33.4 µM -0.00347105187929517 0.491244103928915 no 1712 0.4986152534285 2422 13258915
SGTC_2860 9025725 38.96 µM -0.00348382570576749 0.491238941329646 no 1713 0.49861015743985 2414 40546248
SGTC_2974 9094440 9.66 µM -0.0053528424133919 0.490483586111621 no 1714 0.497864535038862 2446 25236134
SGTC_1407 3909-7909 12.3 µM -0.00571685596796254 0.490336475455162 no 1715 0.49771931686647 2425 4411780
SGTC_2634 4'-methoxyflavone 100 µM -0.00659170773313577 0.489982922558633 no 1716 0.497370308128837 2422 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2997 9067075 71.4286 µM -0.00722263180090656 0.489727952767039 no 1717 0.497118611850814 2425 27209819
SGTC_1433 4060-0023 7.6 µM -0.00769992386716941 0.48953507170753 no 1718 0.496928205167396 2426 3840627
SGTC_718 1130-0073 349 µM -0.00971660415089883 0.488720127761332 no 1719 0.496123696777558 2429 6740020
SGTC_540 1187-0821 17.3 µM -0.0101702525370513 0.488536814040916 no 1720 0.495942726204099 2424 847520
SGTC_2596 sinensetin 100 µM -0.0103105871954151 0.488480107024098 no 1721 0.49588674371093 2432 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2757 clomiphene 4.22 µM -0.0125328293303297 0.487582165907875 no 1722 0.495000255373909 2430 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_449 xestospongin c 11.1929 µM -0.0127130676627992 0.487509339724868 no 1723 0.494928356411012 2445 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1608 st001473 40.5 µM -0.0133970048767607 0.487232995345673 no 1724 0.494655528195129 2431 7292267
SGTC_929 2805-0021 398 µM -0.0139809107373119 0.486997073414269 no 1725 0.49442260528734 2474 3098024
SGTC_1406 3909-7906 11.9 µM -0.0139853379043905 0.486995284674353 no 1726 0.494420839275871 2437 X1406
SGTC_2943 9068529 45.32 µM -0.0143160748884715 0.486861655392272 no 1727 0.494288907519663 2423 3270634
SGTC_2875 9039966 71.43 µM -0.014605420750684 0.486744750776961 no 1728 0.494173487290549 2493 6463691
SGTC_1471 k673-0312 37 µM -0.015841355974593 0.486245407933317 no 1729 0.493680477636456 2437 24099884
SGTC_1136 pergolide 1.05886 µM -0.0162712980964506 0.486071707630652 no 1730 0.493508977655498 2440 47811 A dopamine receptor agonist.
SGTC_1228 0124-0032 52.5 µM -0.0171495135917238 0.485716909289887 no 1731 0.493158669287445 2455 X1228
SGTC_2326 6164455 177.58 µM -0.0172682713647711 0.485668932108471 no 1732 0.493111298805486 2457 2888790
SGTC_1630 st005209 31.3 µM -0.0178005133407289 0.485453913205814 no 1733 0.492898997619408 2430 3367314
SGTC_1574 spiramycin 23.7 µM -0.0179435086881434 0.485396145645491 no 1734 0.492841959839384 2434 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_451 chloral hydrate 100 µM -0.0184615484530874 0.485186869430083 no 1735 0.492635326111552 2457 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1212 0520-0165 585 µM -0.0189666052363984 0.484982841969698 no 1736 0.492433872888054 2457 5403258
SGTC_2143 5623677 140.463 µM -0.0190794815406317 0.484937243938079 no 1737 0.492388849904973 2442 5375313
SGTC_2484 5809818 12.04 µM -0.0196889351280758 0.484691049678374 no 1738 0.492145758779497 2466 2870548
SGTC_286 k060-0067 22.9 µM -0.0208946104406517 0.484204023570758 no 1739 0.491664862966066 2442 5985051
SGTC_279 1273-0055 2.93 µM -0.0234091622962807 0.483188360437691 no 1740 0.490661948277106 2441 2847562
SGTC_2133 5320837 200 µM -0.0240151531100424 0.482943608222149 no 1741 0.490420260879565 2463 2841355
SGTC_2343 7990716 14.84 µM -0.0241933793181928 0.482871626073912 no 1742 0.490349179562431 2451 6456862
SGTC_982 1491-0518 27.5 µM -0.0243372813516745 0.482813507208975 no 1743 0.490291787855874 2466 3091256
SGTC_3350 9150499 3.57 µM -0.0250742062074493 0.482515885225228 no 1744 0.489997887088423 2461 4910996 YPR165W RHO1
SGTC_3192 9110362 49.47 µM -0.0251156600376373 0.482499143546732 no 1745 0.489981354609409 2451 16649480
SGTC_695 3505-6186 243 µM -0.0251444074350846 0.48248753354755 no 1746 0.489969889677846 2469 1819379
SGTC_1417 3966-0327 90.4 µM -0.0252940359375621 0.482427104428908 no 1747 0.489910215521583 2451 651118
SGTC_2629 bisabolol 100 µM -0.0260489771945382 0.482122219273368 no 1748 0.489609136767851 2465 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_795 0685-0265 78 µM -0.0260648176792153 0.482115822160328 no 1749 0.489602819473737 2451 302754
SGTC_2030 5175110 200 µM -0.0268089660152678 0.481815306205676 no 1750 0.489306050971688 2481 2831986
SGTC_2778 tioconazole 65.09 nM -0.0275782799879884 0.481504638255697 no 1751 0.48899925256726 2459 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3213 9129884 49.47 µM -0.0287628946594525 0.481026283673395 no 1752 0.488526847199829 2481 17190742
SGTC_2016 5121758 140 µM -0.0290666688686215 0.480903622180552 no 1753 0.48840570947463 2455 2795203
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.0292068930490309 0.480847001434893 no 1754 0.488349791861099 2476 279621
SGTC_3284 9108171 64.8615 µM -0.0295598144218285 0.480704497973083 no 1755 0.488209057371454 2489 8687505
SGTC_1045 1348-1485 165 µM -0.0305034209340289 0.480323498369539 no 1756 0.48783278257065 2451 6810614
SGTC_2696 st077691 74.316 µM -0.031498269422088 0.479921828287161 no 1757 0.487436086131361 2510 757133
SGTC_628 1636-0253 16 µM -0.033226016937618 0.479224298903956 no 1758 0.486747175528569 2487 4456143
SGTC_2890 9046729 58.44 µM -0.0333373923938424 0.479179336361311 no 1759 0.48670276775154 2490 903329
SGTC_2568 diosmetin 100 µM -0.0339521516496725 0.478931161336899 no 1760 0.486457653066565 2466 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_959 1222-0044 107 µM -0.0353737545444759 0.478357299294697 no 1761 0.485890856224849 2473 6083612
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.0365602486470136 0.47787837851432 no 1762 0.485417819654617 2465 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_796 1234-0020 70.7 µM -0.0375216978237539 0.477490319081649 no 1763 0.485034519982559 2467 46495034
SGTC_2253 7938677 135.83 µM -0.0390121399208329 0.476888790222879 no 1764 0.484440354862749 2508 2301972
SGTC_2434 5670830 169.91 µM -0.0400727730342261 0.476460760344629 no 1765 0.484017554165695 2531 1549830
SGTC_1176 0848-0131 83.3 µM -0.0403948262547087 0.476330797662977 no 1766 0.483889177467564 2509 6769040
SGTC_1525 8-methoxypsoralen 92.5 µM -0.0407029958451905 0.476206439995594 no 1767 0.483766336618729 2491 4114 Related to psoralen; DNA damaging agent.
SGTC_1170 0310-0127 64.8 µM -0.0419424481136068 0.475706299334825 no 1768 0.48327228872606 2522 774975
SGTC_1889 st059080 5.18 µM -0.0421151943251939 0.475636596239154 no 1769 0.48320343379885 2480 176925 Isolated from Daphnopsis sellowiana.
SGTC_1807 st050092 58.9 µM -0.0423336569788573 0.475548447627232 no 1770 0.483116357468684 2485 5008496
SGTC_938 3126-1755 342 µM -0.0431544433408765 0.475217275075831 no 1771 0.482789210089357 2479 1777771
SGTC_77 0828-0286 12.516 µM -0.045893202515962 0.474112360114562 no 1772 0.481697686038445 2481 745345
SGTC_566 0958-0068 16.5 µM -0.0460085225588013 0.474065840128121 no 1773 0.481651728542432 2497 6815365
SGTC_877 0771-0151 33.1 µM -0.0462340192980189 0.473974875998304 no 1774 0.481561863988767 2564 6166523
SGTC_699 0375-0592 111 µM -0.0466506256764852 0.473806822876079 no 1775 0.481395841234244 2479 762578
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.0467188514907945 0.473779301990691 no 1776 0.481368652716665 2505 65057 A dermal irritant. YDR527W RBA50
SGTC_2456 5770359 74.46 µM -0.0473121409754147 0.473539986547273 no 1777 0.481132225910281 2495 3118787
SGTC_490 phenamil 164 µM -0.0483079795573194 0.473138316205276 no 1778 0.480735397606593 2508 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_131 0141-0277 33.849 µM -0.0488642096358576 0.472913973306994 no 1779 0.48051375567286 2537 1547771
SGTC_3060 1327-0027 12.5 µM -0.0492210016866345 0.472770073772443 no 1780 0.48037158731214 2518 16000455 YPR107C YTH1
SGTC_1522 st012842 45.6 µM -0.0500495845614029 0.472435907730864 no 1781 0.480041437519402 2486 3491067 YOR116C RPO31
SGTC_1044 1222-0021 1.78 µM -0.0507310249121325 0.472161098542972 no 1782 0.479769927083399 2620 4306703
SGTC_1641 st009299 47.1 µM -0.0509042086914296 0.472091259623027 no 1783 0.479700925904552 2493 4046054
SGTC_1304 1165-0502 251 µM -0.0511172327746644 0.472005355688495 no 1784 0.47961605208784 2520 767425
SGTC_661 1304-0007 33.6 µM -0.0511289990746145 0.472000610856979 no 1785 0.479611364143453 2522 3117130
SGTC_2902 5787006 60.46 µM -0.0517638828694492 0.471744596041842 no 1786 0.479358417122416 2506 591003
SGTC_493 zm226600 134 µM -0.0518053144349723 0.47172788930312 no 1787 0.479341910466524 2602 5240098 A potassium channel opener. YCR052W RSC6
SGTC_562 3772-2733 112 µM -0.0545880495980882 0.470605902981118 no 1788 0.478233329801217 2517 2876874 YIL048W NEO1
SGTC_1396 3511-0007 98.6 µM -0.0559710485929062 0.47004837022733 no 1789 0.477682435434999 2559 X1396
SGTC_3270 9137563 49.47 µM -0.0564464840836167 0.469856719922133 no 1790 0.477493063507584 2647 17015724
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0583344913697044 0.469095724570219 no 1791 0.476741097071133 2554 75037 A free radical scavenger.
SGTC_1507 4075-3230 155 µM -0.0586006281382068 0.468988462364892 no 1792 0.476635105181316 2482 659771
SGTC_3231 9132313 49.47 µM -0.0590990961651947 0.46878756879103 no 1793 0.476436589270483 2549 4905967
SGTC_2646 retinol 96.75 µM -0.0611774169220316 0.467950046054945 no 1794 0.475608957361886 2572 445354 A vitamin A analog and teratogen.
SGTC_2214 7179297 48.276 µM -0.0627705953206286 0.467308122074191 no 1795 0.474974590606671 2503 769744
SGTC_823 0417-1665 178 µM -0.0633742748956172 0.467064909414134 no 1796 0.474734235861279 2579 3429856
SGTC_3081 9117243 49.47 µM -0.0647740987203555 0.466500990680574 no 1797 0.474176932178398 2647 45595589
SGTC_2344 7990960 76.95 µM -0.0655848281447292 0.466174419179705 no 1798 0.473854184245629 2554 140813
SGTC_2245 6637752 200 µM -0.066774620096294 0.465695198059964 no 1799 0.473380564265557 2556 681890
SGTC_39 0986-0283 58.349 µM -0.0675220947755205 0.4653941576673 no 1800 0.473083036537733 2562 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1859 st055998 20 µM -0.0701786171995677 0.464324422589635 no 1801 0.472025746679623 2531 676301
SGTC_1546 5-methoxyflavanone 78.7 µM -0.0702506976343154 0.464295400618289 no 1802 0.471997061544109 2554 147795
SGTC_831 k061-1017 217 µM -0.0708640001117242 0.464048472419871 no 1803 0.471752997532497 2604 1240153
SGTC_1947 st076332 61.6 µM -0.0712143744464165 0.463907410711594 no 1804 0.471613570654848 2521 24208416
SGTC_3265 9137266 49.47 µM -0.0715594921142213 0.463768469787843 no 1805 0.471476238999849 2517 17224265
SGTC_1874 staurosporine 7.6 µM -0.0719673564399082 0.463604273385035 no 1806 0.471313943126296 2600 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_772 k072-0172 35.3 µM -0.0721664328418107 0.463524132246339 no 1807 0.471234729104447 2552 5861980
SGTC_2083 5306046 65.942 µM -0.0724157218395148 0.463423779375055 no 1808 0.471135536712121 2549 539837
SGTC_1794 st048918 76.9 µM -0.0727586510802335 0.463285734832708 no 1809 0.470999087681519 2515 672303
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0743778317708699 0.462634001302371 no 1810 0.470354873810488 2617 521171
SGTC_1658 st012944 20 µM -0.0746644149267109 0.462518659624663 no 1811 0.470240860693191 2575 24207260
SGTC_860 0443-0016 25.1 µM -0.074915157729682 0.462417745267809 no 1812 0.470141108161826 2548 5337942
SGTC_2090 5301565 104.445 µM -0.0754582818495858 0.462199166953148 no 1813 0.469925044561835 2561 2056344
SGTC_369 0957-0393 4.5 µM -0.0765271629477295 0.461769033066851 no 1814 0.469499852213781 2566 6997992
SGTC_1168 k815-0004 80.5 µM -0.0766978044347318 0.461700368482861 no 1815 0.469431975602451 2536 642433
SGTC_2020 4017018 200 µM -0.0776656410963605 0.461310941462665 no 1816 0.469047012976591 2608 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3242 9133940 49.47 µM -0.0782557169671944 0.461073531677289 no 1817 0.468812321064438 2690 17248444
SGTC_1776 st049249 45.9 µM -0.078538095628505 0.460959924990859 no 1818 0.468700013932586 2571 1822314
SGTC_1040 k898-0338 155 µM -0.080931069294706 0.459997311776753 no 1819 0.467748385638431 2548 20969351
SGTC_2589 lobaric acid 100 µM -0.0816884805637507 0.459692679147698 no 1820 0.467447219460894 2586 73157 A novel microtubule depolymerizer.
SGTC_1089 terbinafine 2.25 µM -0.0817331149177795 0.459674727839997 no 1821 0.46742947227483 2618 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3261 9137475 49.47 µM -0.0826973733477795 0.459286936831318 no 1822 0.467046086742495 2542 17027690
SGTC_1957 st077035 62.4 µM -0.0832344087268307 0.459070976758642 no 1823 0.466832576723181 2564 705593
SGTC_444 curcumin 90.4 µM -0.0842654276652402 0.458656403111042 no 1824 0.466422699667214 2630 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2249 haloperidol 116.36 µM -0.0846576554573761 0.458498699743282 no 1825 0.466266780555545 2542 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_943 3253-1379 105 µM -0.0848871963959897 0.458406411047827 no 1826 0.466175535420372 2631 668464
SGTC_1829 berberine 14.4 µM -0.0853230563111453 0.458231176399652 no 1827 0.466002281041283 2712 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2278 7948257 134.34 µM -0.0857787851773481 0.458047962250584 no 1828 0.465821135642098 2554 1247028
SGTC_2493 resveratrol 26.09 µM -0.085881220364072 0.458006782025998 no 1829 0.465780420162852 2540 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2054 5233173 129 µM -0.0866218263993185 0.45770906258691 no 1830 0.465486058075541 2644 6889
SGTC_3170 9103054 49.47 µM -0.0877970804480516 0.457236665874127 no 1831 0.46501897913535 2621 16432970
SGTC_1307 1187-1599 12.2 µM -0.0879087688275747 0.457191775544985 no 1832 0.464974593536534 2564 1538471
SGTC_1078 idebenone 36.1 µM -0.0879118487602589 0.457190537651406 no 1833 0.464973369559897 2626 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1900 st060200 72.8 µM -0.0880187937774485 0.457147554323523 no 1834 0.464930869420247 2548 688945
SGTC_519 k048-0011 62.8 µM -0.0880338916790148 0.457141486217191 no 1835 0.464924869519582 2687 6836379
SGTC_2093 5331342 194.4 µM -0.0887085666585108 0.456870332959319 no 1836 0.464656762085411 2605 33839
SGTC_960 1222-0186 7.7 µM -0.0893105266162 0.456628420963859 no 1837 0.464417564236365 2657 3126296
SGTC_90 0870-0863 4.608 µM -0.0898275537759838 0.45642065407129 no 1838 0.464212125975341 2565 1738164
SGTC_1752 st044819 83.042 µM -0.0900417432924545 0.456334585696389 no 1839 0.464127021590628 2594 441209 YML126C ERG13
SGTC_2069 5228469 200 µM -0.090559303403542 0.456126621527476 no 1840 0.463921385092367 2655 2835210
SGTC_2521 angolensin 13.4 µM -0.0907226414343474 0.456060992111322 no 1841 0.463856489777257 2671 821428 A flavenoid.
SGTC_2359 9039622 200 µM -0.0907873164034275 0.456035005962598 no 1842 0.463830794236036 2592 6463596
SGTC_75 0159-0059 199.013 µM -0.0909843921136841 0.455955822875832 no 1843 0.463752496450809 2606 5377270
SGTC_1591 genipin 88.4 µM -0.096219899120439 0.453852897781062 no 1844 0.461672963464011 2737 442424 A DNA cross-linking agent.
SGTC_499 genistein 192 µM -0.0974652631444095 0.453352865588135 no 1845 0.461178459426971 2573 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_504 lovastatin 124 µM -0.0977727852607858 0.453229402234861 no 1846 0.46105635901761 2586 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2994 9053520 71.4286 µM -0.0980274133356699 0.453127178094437 no 1847 0.460955262750762 2648 4647384
SGTC_91 0417-1751 58.384 µM -0.0981812080832066 0.453065436462551 no 1848 0.460894202069582 2553 6795624
SGTC_1302 1159-0335 255 µM -0.0984845292276233 0.452943670075367 no 1849 0.46077377806179 2583 649284
SGTC_844 0330-0132 15.3 µM -0.0986814076495834 0.452864636824515 no 1850 0.460695615674165 2590 2828079
SGTC_3142 9086498 49.47 µM -0.0995839668166657 0.452502344860653 no 1851 0.460337311585513 2608 25236367
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.10023469155852 0.452241165063998 no 1852 0.460079002405002 2880 5282309
SGTC_1205 4161-2785 76 µM -0.103046831375024 0.45111270244077 no 1853 0.458962901348161 2735 3498106
SGTC_1342 1486-1464 234 µM -0.103209066412861 0.451047612315843 no 1854 0.458898522192336 2585 3253938
SGTC_1847 st056231 15 µM -0.103645490409765 0.450872521705565 no 1855 0.458725342957316 2576 5393180
SGTC_2940 9060638 45.86 µM -0.105207961096079 0.450245746734787 no 1856 0.45810539687123 2673 4027022
SGTC_2541 muurolladie-3-one 83.07 µM -0.106021457041857 0.449919467135425 no 1857 0.457782663937997 2768 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_570 0987-0065 62.6 µM -0.107514307028546 0.449320798224125 no 1858 0.457190487872027 2579 3104428
SGTC_3316 9136639 10.545 µM -0.107589331721607 0.449290714542414 no 1859 0.457160729959325 2689 4903665
SGTC_971 1315-0384 26.7 µM -0.107805306883404 0.449204113643131 no 1860 0.457075066571766 2627 6769120
SGTC_785 1270-0111 65.3 µM -0.108472418408434 0.44893663309799 no 1861 0.456810479159584 2588 6741994
SGTC_2877 9040724 71.43 µM -0.108713912441935 0.448839810990925 no 1862 0.456714703364379 2612 6463895
SGTC_744 1594-0068 283 µM -0.109898301518502 0.448364998568946 no 1863 0.456245014788787 2613 668392
SGTC_412 gemfibrozil 100 µM -0.110150438531931 0.448263928315156 no 1864 0.456145033662902 2588 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1977 st070720 65.3 µM -0.110533008862894 0.448110579695909 no 1865 0.45599333647925 2706 682188
SGTC_2274 7947094 46.08 µM -0.111184245177198 0.447849557462525 no 1866 0.455735122347143 2592 2971028
SGTC_3055 9094636 49.47 µM -0.113716497741436 0.446834820133801 no 1867 0.454731267026249 2727 25236176
SGTC_2216 7189485 200 µM -0.11387040496371 0.4467731567876 no 1868 0.454670263177336 2635 731273
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.114058983800168 0.446697603919644 no 1869 0.454595518078736 2603 88881 An O-methylated flavonoid and antioxidant.
SGTC_426 0988-0037 14.6 µM -0.114237717170379 0.446625997358639 no 1870 0.454524676812596 2573 5383008
SGTC_3252 9135871 49.47 µM -0.115879582341097 0.44596829301718 no 1871 0.453873988800449 2745 17682838
SGTC_1832 st054113 55 µM -0.117303727974022 0.445397923879454 no 1872 0.453309685466279 2605 1251267
SGTC_3342 9147791 14.508 µM -0.117811388712694 0.445194633436057 no 1873 0.453108552753319 2613 1838168
SGTC_384 k007-0144 5.16 µM -0.118599859954505 0.444878922291218 no 1874 0.45279618815492 2690 6824886
SGTC_599 1935-0052 86.5 µM -0.12028713775617 0.444203438434359 no 1875 0.452127846357042 2621 9557311
SGTC_3186 9110464 49.47 µM -0.120695889292234 0.444039823379946 no 1876 0.451965957531481 2732 17018021
SGTC_1366 1683-0113 21.9 µM -0.120805121573825 0.44399610149877 no 1877 0.451922696694734 2622 708623
SGTC_277 nystatin 15.5 µM -0.120893370382085 0.44396077906952 no 1878 0.451887746662606 2594 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1214 0358-0031 63.7 µM -0.121078054534129 0.443886858912869 no 1879 0.451814605612226 2918 4301366
SGTC_2767 sibutramine 71.45 µM -0.121863859028794 0.443572361136909 no 1880 0.451503419280005 2710 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_345 1362-0200 395 µM -0.123093991125889 0.443080104248668 no 1881 0.451016334740827 2639 1419823
SGTC_34 0469-0683 81.75 µM -0.12345009881099 0.442937618466325 no 1882 0.450875343659637 2702 3690923
SGTC_138 0850-0259 40.9225 µM -0.124611126387439 0.442473119536916 no 1883 0.450415709738605 2642 6813004
SGTC_1432 4049-0298 68.4 µM -0.125677817294155 0.442046432095584 no 1884 0.449993480926608 2709 741646
SGTC_54 0159-0055 9 µM -0.126677137752481 0.441646754518793 no 1885 0.449597970735613 2669 3319099
SGTC_140 0062-0056 502.533 µM -0.126972157065205 0.441528773073598 no 1886 0.449481217800231 2613 3758964
SGTC_625 k213-0058 121 µM -0.12817503846314 0.441047781474043 no 1887 0.449005226765909 2690 3655420
SGTC_333 3486-0131 40.1 µM -0.128321389584689 0.440989266527627 no 1888 0.448947319298891 2774 6744690
SGTC_1423 4048-0112 5.59 µM -0.12848887784998 0.440922301987836 no 1889 0.448881049728902 2715 X1423
SGTC_918 glabranin 770.725 nM -0.128535294213304 0.440903744267689 no 1890 0.4488626845606 2683 124049 Also referred to as licorice root.
SGTC_1439 4092-1168 46 µM -0.129009518026892 0.440714152349787 no 1891 0.44867505873652 2630 2886240
SGTC_1631 benzylvanillin 81.9 µM -0.129149224870814 0.44065830095689 no 1892 0.448619786154617 2759 75506
SGTC_1912 st060209 90.8 µM -0.129357400774366 0.440575079492232 no 1893 0.448537426831129 2714 688787
SGTC_1732 st034308 51.822 µM -0.129592952785881 0.440480917179837 no 1894 0.448444239544895 2599 830119
SGTC_1393 3470-5649 58.2 µM -0.129809658818311 0.440394291551603 no 1895 0.448358510473031 2729 4108395
SGTC_2611 pyromycin 23.93 µM -0.130923201057583 0.439949211523364 no 1896 0.447918030432792 2688 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1607 st000305 50.6 µM -0.131166010609991 0.439852171214041 no 1897 0.447821991609296 2792 5457690
SGTC_3259 9138485 49.47 µM -0.131935006289166 0.439544861301073 no 1898 0.447517849813811 2810 17646153
SGTC_1117 retinoic acid 1.10837 µM -0.133983950077767 0.438726230420411 no 1899 0.446707632988163 2760 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_916 4466-0038 42 nM -0.134310523496895 0.438595776055669 no 1900 0.446578516047246 2693 5722064 YGL116W CDC20
SGTC_2759 disulfiram 3.38 µM -0.134434984353837 0.438546060163379 no 1901 0.446529309597266 2648 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2927 9011802 47.9 µM -0.136494459789626 0.437723544009807 no 1902 0.445715202005093 2747 43912568
SGTC_551 k048-0028 34.9 µM -0.137057998172966 0.437498523997005 no 1903 0.445492475845604 2778 6836383
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.13834080757055 0.436986375660281 no 1904 0.444985537885024 2666 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2643 anethole 100 µM -0.138791997988316 0.436806267624663 no 1905 0.444807258732004 2658 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1039 k821-0043 94 µM -0.139200702059391 0.436643130767806 no 1906 0.444645776871279 2648 15992768
SGTC_1920 st075728 45.7 µM -0.139233659091164 0.436629976225845 no 1907 0.444632755715522 2719 3400306
SGTC_114 0364-0001 490.298 µM -0.139302331543117 0.436602566377878 no 1908 0.444605623770748 2689 4003655
SGTC_2074 5212007 75.395 µM -0.139709026696306 0.436440244759303 no 1909 0.444444947043971 2651 758611
SGTC_1754 st042065 16.137 µM -0.140528584373972 0.436113172521775 no 1910 0.444121184752972 2705 1126236 YIL048W NEO1
SGTC_2899 9053889 58.44 µM -0.143011904701457 0.435122387091554 no 1911 0.443140389623472 2663 6470052
SGTC_3129 9127257 49.47 µM -0.143419694795776 0.434959727353259 no 1912 0.442979364782527 2688 837894
SGTC_1451 4152-0210 104 µM -0.143740594991317 0.434831734085718 no 1913 0.442852656939082 2685 659563
SGTC_2305 7443522 69.23 µM -0.144219726696797 0.434640641797738 no 1914 0.442663482067654 2679 5415886
SGTC_2324 6149169 200 µM -0.144382172994749 0.434575856739902 no 1915 0.442599346598189 2739 2888231
SGTC_3258 9138477 49.47 µM -0.144716767584832 0.434442422918484 no 1916 0.442467249953998 2676 4970355
SGTC_2284 7945075 39.21 µM -0.145237544143737 0.434234755982241 no 1917 0.4422616621222 2790 1245402
SGTC_418 lividomycin a 100 µM -0.146273192534969 0.433821830685497 no 1918 0.44185286373901 2683 72394 An antibiotic.
SGTC_2174 5790901 200 µM -0.14709737268288 0.433493271862738 no 1919 0.441527581808379 2754 786020
SGTC_2336 9001819 198.65 µM -0.147964864625849 0.433147496468801 no 1920 0.441185248466997 2854 2989602
SGTC_1959 st077091 55.8 µM -0.148613205215429 0.432889106461544 no 1921 0.44092942623674 2643 821356 YKL052C ASK1
SGTC_582 0987-0078 156 µM -0.149066397714149 0.4327085079097 no 1922 0.440750620170017 2681 1625765
SGTC_3266 9136860 49.47 µM -0.149444193461234 0.432557965927395 no 1923 0.440601570949967 2668 4871271 YPR165W RHO1
SGTC_41 0478-0632 82.643 µM -0.149573610082155 0.432506398950316 no 1924 0.440550515013246 2670 3750424
SGTC_725 1497-0963 19 µM -0.150137196239953 0.432281847434741 no 1925 0.440328187105874 2761 3549977
SGTC_2273 7815444 169.05 µM -0.150769512082365 0.432029937760691 no 1926 0.440078768566948 2827 2824616
SGTC_2357 9067248 200 µM -0.154145320321134 0.430685512247389 no 1927 0.438747577414286 2767 9150235
SGTC_1054 3429-0080 167 µM -0.154514642628128 0.430538477005378 no 1928 0.438601983357938 2806 1162877
SGTC_2205 7238770 200 µM -0.154592888317083 0.430507326930509 no 1929 0.438571138447224 2771 279867
SGTC_1722 st034304 3.6505 µM -0.155096636303172 0.430306792218133 no 1930 0.438372566970079 2717 4036148 YLR033W RSC58
SGTC_2000 st075254 36.4 µM -0.155237913363077 0.430250555109968 no 1931 0.438316880013286 2695 17234175
SGTC_757 1066-0008 322 µM -0.155372828407377 0.430196851802668 no 1932 0.438263701902206 2839 6842497
SGTC_2120 5538279 151.968 µM -0.157789910916617 0.42923494512532 no 1933 0.437311174491874 2706 2058197
SGTC_1495 4469-0029 237 µM -0.15795899693368 0.429167670991965 no 1934 0.437244554357074 2683 793680
SGTC_1108 betulinic acid 729.144 nM -0.159351543591142 0.428613697864178 no 1935 0.436695956804027 2711 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_633 0437-0093 97.7 µM -0.159883320931056 0.428402186981913 no 1936 0.43648649373115 2665 2831118
SGTC_1035 k081-0041 55.2 µM -0.160392091509799 0.428199846133802 no 1937 0.436286109516005 2667 731709
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.161107750049102 0.427915256771778 no 1938 0.436004268164226 2935 6710655
SGTC_2391 6285546 200 µM -0.161841428958493 0.427623540337312 no 1939 0.435715363745262 2664 846083
SGTC_1773 st048542 73.5835 µM -0.162306271607404 0.427438735751735 no 1940 0.435532338069001 2672 3237138
SGTC_1971 st069429 63.5 µM -0.162457400771123 0.427378655702518 no 1941 0.435472835922023 2798 1246522 YGL099W LSG1
SGTC_1616 st002734 56.1 µM -0.162690652276041 0.427285931956107 no 1942 0.435381003666874 2720 4026101
SGTC_2777 climbazole 1.536 µM -0.164164318899283 0.426700202901991 no 1943 0.434800894686612 2715 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1587 estradiol valerate 56.1 µM -0.164178880862614 0.426694415853744 no 1944 0.43479516306676 2745 13791 A steroid.
SGTC_1905 st060207 84.5 µM -0.16444514621414 0.426588602518839 no 1945 0.434690362873214 2683 1948547
SGTC_874 0599-0792 117 µM -0.164627575911106 0.42651610836021 no 1946 0.434618562459714 2720 765305
SGTC_1737 st035557 69.7 µM -0.164922404545073 0.426398954209707 no 1947 0.434502528796362 2647 5716916
SGTC_1072 oxiconazole 14.9 nM -0.165323374804065 0.426239633670827 no 1948 0.434344730764909 2708 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1763 st044482 94.5 µM -0.166110591897162 0.425926877800549 no 1949 0.434034959415837 2834 88505
SGTC_1762 st045503 25.4615 µM -0.166433146789623 0.42579874243199 no 1950 0.433908045170319 2763 4645554
SGTC_3131 9127911 49.47 µM -0.166568113363223 0.425745129101832 no 1951 0.433854942491211 2943 45595681
SGTC_842 0271-0008 11.1 µM -0.167091256190707 0.4255373318942 no 1952 0.433649122922831 2813 1221709
SGTC_681 1642-0006 26.6 µM -0.168767046370928 0.424871831916365 no 1953 0.4329899398265 2696 4446530
SGTC_2620 irigenin 100 µM -0.169882664980659 0.424428909246218 no 1954 0.432551207145705 2857 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1696 st025591 34.7925 µM -0.170982834207293 0.423992213724564 no 1955 0.432118631572817 2723 2787147
SGTC_3023 9089636 49.47 µM -0.173366277140192 0.423046462878555 no 1956 0.431181765322028 2709 17249241
SGTC_942 3253-1115 227 µM -0.174231363546863 0.422703305702649 no 1957 0.43084181897047 2872 46497897
SGTC_2295 7971645 200 µM -0.17543252905099 0.422226932033946 no 1958 0.43036989121112 2796 2978226 YKL099C UTP11
SGTC_2162 5663267 200 µM -0.176149201547612 0.421942758971375 no 1959 0.430088363974239 2766 6456493
SGTC_3009 9080819 71.4286 µM -0.176903010475108 0.421643904522908 no 1960 0.429792286950772 2785 17027216
SGTC_2139 5578692 56.4705 µM -0.177707284164506 0.42132509261906 no 1961 0.429476432185613 2760 650991 YMR113W FOL3
SGTC_1656 st012921 11 µM -0.178520202729482 0.421002906317508 no 1962 0.429157228272132 2834 6732821
SGTC_2085 5307070 144.047 µM -0.178536154827754 0.420996584506029 no 1963 0.429150964919003 2705 2840351
SGTC_2206 7254556 146.969 µM -0.179398718344571 0.420654781230603 no 1964 0.428812318837727 2772 4398905
SGTC_1223 0764-0573 147 µM -0.180866914664738 0.420073124872968 no 1965 0.428236019391565 2722 1609797
SGTC_1389 3405-0187 19 µM -0.180888420611241 0.420064606141067 no 1966 0.428227578967265 2777 799890
SGTC_2031 5180455 200 µM -0.181884509882302 0.419670085790862 no 1967 0.427836680526064 2724 29949
SGTC_1268 0828-0275 2.46 µM -0.183804913155359 0.418909701243213 no 1968 0.427083250834163 2839 745337
SGTC_116 0155-0182 31.788 µM -0.18447066310864 0.418646167789749 no 1969 0.426822119822713 2743 771486
SGTC_676 falcarinol 140 µM -0.185370752948361 0.418289930247145 no 1970 0.426469123309141 2852 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2798 7813637 45.45 µM -0.1864385724274 0.417867395602303 no 1971 0.426050423118961 2873 956368
SGTC_756 0508-1999 28.3 µM -0.187413186960708 0.417481824749882 no 1972 0.425668342042274 2750 6753853
SGTC_126 0417-1624 672.48 µM -0.188283984332298 0.417137392476965 no 1973 0.425327019739021 2764 41912 YDL195W SEC31
SGTC_2397 5161689 200 µM -0.188855493691579 0.416911374122979 no 1974 0.425103038332853 2923 2259942
SGTC_2854 9024559 71.43 µM -0.189662120989617 0.41659241896339 no 1975 0.424786952525879 2831 3163529
SGTC_3160 9100216 49.47 µM -0.189687890624994 0.416582230083062 no 1976 0.424776855205917 2698 17191039
SGTC_1359 1582-0056 520 nM -0.190752143819781 0.416161491301571 no 1977 0.424359891909203 2847 3661189
SGTC_3049 9092223 49.47 µM -0.190962970817092 0.416078154949968 no 1978 0.424277302121228 2843 8623917
SGTC_1339 1486-1321 22.7 µM -0.192143327780903 0.415611649575926 no 1979 0.423814968252448 2756 3469382
SGTC_484 loperamide 105 µM -0.192993993119867 0.415275519926958 no 1980 0.423481836225647 2708 3955 An opioid-receptor agonist.
SGTC_415 dibenzyl ketone 100 µM -0.193520895784788 0.415067352081638 no 1981 0.423275521443598 2826 7593
SGTC_878 0828-0289 13.7 µM -0.195734064426654 0.414193238079078 no 1982 0.422409160266993 2778 745350 YLR208W SEC13
SGTC_1993 st073995 70.8 µM -0.196268601610008 0.41398218058889 no 1983 0.422199967848987 2771 3098394
SGTC_3139 9095020 49.47 µM -0.196318291738646 0.413962562122521 no 1984 0.422180522611078 2702 25236292
SGTC_602 3130-1533 38.1 µM -0.197118921100346 0.413646490336625 no 1985 0.421867238507951 2878 720941
SGTC_2532 xanthone 78.9 µM -0.19775284907679 0.413396268455292 no 1986 0.421619219265793 2865 7020 An insecticide.
SGTC_1001 4048-4355 44.4 µM -0.197892826903843 0.413341021623198 no 1987 0.421564458249446 2764 21824233
SGTC_1290 0986-0249 10.2 µM -0.199629624976364 0.412655680456202 no 1988 0.420885128368974 2824 53329
SGTC_2468 5987765 72.9 µM -0.20070604318991 0.412231058900037 no 1989 0.420464217045231 2806 26772094
SGTC_2903 5923464 63.88 µM -0.200955289521625 0.412132751738919 no 1990 0.420366767313069 2852 2876576
SGTC_1750 st081859 2.357 µM -0.201513810978463 0.411912481027592 no 1991 0.420148415666978 2784 5291695
SGTC_1501 4491-0275 38.4 µM -0.202202986386795 0.411640721028693 no 1992 0.419879019276961 2760 5104718
SGTC_2444 5485484 36.41 µM -0.20247398274807 0.411533871634075 no 1993 0.419773097970507 2884 6790631
SGTC_2571 chrysanthemic acid 100 µM -0.203183979751074 0.411253962658489 no 1994 0.419495616988441 2821 2743 An insecticide.
SGTC_31 0508-1974 57.237 µM -0.203564446422253 0.411103986187496 no 1995 0.419346939491953 2852 6810525
SGTC_1521 st012942 49.4 µM -0.203753032771394 0.411029651993527 no 1996 0.419273248614512 2997 24207259
SGTC_1227 3909-8010 46.6 µM -0.204664268009294 0.410670519744312 no 1997 0.418917219706246 2786 15982272
SGTC_3356 9151811 4.48 µM -0.206165269538443 0.410079114639967 no 1998 0.418330907974452 2757 1859254 YPR165W RHO1
SGTC_2698 st077697 67.5 µM -0.206283903340421 0.410032380793545 no 1999 0.418284575707424 2814 3154499
SGTC_441 propafenone 146 µM -0.206425728132576 0.409976512912792 no 2000 0.418229187719337 2746 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2478 5763493 32.33 µM -0.207528753699289 0.40954206952797 no 2001 0.417798469614345 2757 1365576 YLR208W SEC13
SGTC_1134 3477-0009 42.5 µM -0.207858388099722 0.409412259537884 no 2002 0.417669770489373 3036 3973534
SGTC_337 1315-0038 354 µM -0.208305612204304 0.409236158615533 no 2003 0.417495174928079 2781 1626437
SGTC_2692 st077426 47.7 µM -0.208890831361211 0.409005747826114 no 2004 0.417266730895038 2919 25238571
SGTC_2114 5491910 81.25 µM -0.209580820769147 0.408734127587513 no 2005 0.416997425002902 2894 2849228
SGTC_33 0986-0033 35.816 µM -0.21096943185547 0.40818762193003 no 2006 0.416455562175338 2773 2848082
SGTC_2312 7706453 155.7 µM -0.211313947802719 0.408052060874237 no 2007 0.416321149943337 2831 976098
SGTC_1046 2001-0062 216 µM -0.21243311739799 0.407611763055711 no 2008 0.415884575687822 2762 739778
SGTC_2186 6124449 200 µM -0.213014220342854 0.407383194573641 no 2009 0.415657935496312 2941 3834182 YLR033W RSC58
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.213290537219013 0.407274520362385 no 2010 0.415550176975572 2760 4620898
SGTC_2393 9031399 185.94 µM -0.213960959032782 0.407010876095145 no 2011 0.415288751159825 2932 1526623 YDL150W RPC53
SGTC_407 eburnamonine 100 µM -0.215595843186571 0.406368132599476 no 2012 0.414651398131504 2766 3195
SGTC_1686 st019653 115.5 µM -0.218771540724855 0.405120351113248 no 2013 0.413414008538518 2908 97252
SGTC_2616 abietic acid 100 µM -0.218998957212881 0.405031032435071 no 2014 0.413325430037674 2887 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2691 st077356 60.2 µM -0.219126969270633 0.404980757395237 no 2015 0.413275571405924 2957 2839272
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.219183476953254 0.404958565250347 no 2016 0.413253563019864 2787 15053
SGTC_3324 9138759 60.749 µM -0.220456474723456 0.404458704610545 no 2017 0.412757833309904 2921 45595710
SGTC_3182 9108849 49.47 µM -0.223190159425885 0.40338581239073 no 2018 0.411693755214938 2889 17133045
SGTC_430 0958-0115 16.4 µM -0.224662359764378 0.402808316874922 no 2019 0.411120974306015 2829 6833180
SGTC_2237 6667747 47.222 µM -0.224792156589391 0.402757412022225 no 2020 0.41107048403628 2820 729940 YDL015C TSC13
SGTC_1282 0886-0010 32.4 µM -0.225979733706576 0.402291734298299 no 2021 0.41060859140074 2950 2836211 YNL267W PIK1
SGTC_2597 laccaic acid a 100 µM -0.226226341851637 0.402195050639107 no 2022 0.410512691898432 2933 5491415 A textile dye.
SGTC_2164 5685496 200 µM -0.226419777576611 0.402119217616173 no 2023 0.410437473512997 2823 759046
SGTC_1606 st000094 49.2 µM -0.228307887334916 0.401379211796796 no 2024 0.409703446632781 2894 1242210
SGTC_621 3584-0052 32.1 µM -0.229175197617399 0.401039405705569 no 2025 0.409366374522747 2857 2273927
SGTC_74 000s-0487 160.283 µM -0.230196829145712 0.400639233659894 no 2026 0.408969412839939 2778 677548
SGTC_528 3492-0019 172 µM -0.23092494059825 0.400354096738623 no 2027 0.408686557269465 2878 2869262
SGTC_550 4123-0385 25.7 µM -0.231970952604465 0.399944559233879 no 2028 0.408280287469663 2820 5731123
SGTC_898 1000-0849 28.3 µM -0.232358682069541 0.399792782251103 no 2029 0.40812971883099 2799 6751807
SGTC_578 3460-0051 92 µM -0.232658845097784 0.39967529360928 no 2030 0.408013164554725 2826 2876744
SGTC_336 4111-0029 111 µM -0.23316332800069 0.399477851345799 no 2031 0.407817290549962 2865 3131175
SGTC_1719 st032227 49.2 µM -0.234084050729709 0.399117569303042 no 2032 0.407459863832163 2839 3125804
SGTC_2193 5925765 200 µM -0.238244265862107 0.397490737914431 no 2033 0.405845823080327 2935 877370
SGTC_1369 1866-0067 208 µM -0.238326852845507 0.397458460626638 no 2034 0.405813797865855 2947 3531355
SGTC_206 4546-0025 72.014 µM -0.238588844475544 0.397356071665697 no 2035 0.405712208084982 2880 6620745 YIL048W NEO1
SGTC_1613 st002381 52.1 µM -0.239484517959095 0.397006086930656 no 2036 0.405364950057496 2830 551167
SGTC_2103 5378138 10 µM -0.23979385127174 0.396885234080071 no 2037 0.40524503695065 2833 244142
SGTC_1944 st076371 56.9 µM -0.240227431234551 0.396715856209075 no 2038 0.405076974583545 2833 24208455
SGTC_1785 bathophenanthroline 24 µM -0.240450983833176 0.396628533070718 no 2039 0.404990328941211 2847 72812 An iron chelator.
SGTC_1246 0422-0085 105 µM -0.241388865479794 0.396262238389959 no 2040 0.404626870852169 2967 264295
SGTC_1581 himbacine 57.9 µM -0.24168713770454 0.396145765754944 no 2041 0.404511298387198 2825 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1973 st070275 50.2 µM -0.242220606744152 0.395937473990659 no 2042 0.40430461426378 2801 17118334
SGTC_1561 5-methoxyflavone 52.9 µM -0.242566826317862 0.395802309245161 no 2043 0.404170491264358 2819 94525
SGTC_3337 9144342 33.5465 µM -0.242835617938423 0.395697381150648 no 2044 0.404066371068937 2919 17682949
SGTC_818 4072-2707 53.5 µM -0.24309000398002 0.395598083519133 no 2045 0.403967837335349 2794 882871
SGTC_612 0302-0167 22.4 µM -0.24377315192492 0.395331455533553 no 2046 0.403703257397418 2911 235821
SGTC_1173 0443-0020 122 µM -0.244569869267296 0.395020564077802 no 2047 0.40339474823508 2846 5331295
SGTC_2475 5812728 15.03 µM -0.245346774258244 0.394717468055835 no 2048 0.403093968800825 2801 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1881 5652484 16 µM -0.246081330833408 0.394430952129908 no 2049 0.402809637313635 2981 2255129
SGTC_1259 0671-0132 43 µM -0.246670459126036 0.394201202185748 no 2050 0.402581635202873 2862 X1259
SGTC_1553 gossypol 38.6 µM -0.248336939346394 0.393551503010012 no 2051 0.401936860249569 2816 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_808 0711-0032 135 µM -0.251582298364898 0.39228710896625 no 2052 0.400681971238451 2854 4252555
SGTC_3162 9099653 49.47 µM -0.252315700383226 0.392001531983449 no 2053 0.400398526747661 2910 25237511
SGTC_1489 4065-0444 182 µM -0.252784240748102 0.391819119044211 no 2054 0.400217473174811 2969 2877968
SGTC_1009 4106-0057 9.87 µM -0.254669431390068 0.391085414085675 no 2055 0.399489214064473 2898 2928005
SGTC_2028 5153890 36.43 µM -0.255049606553357 0.390937499041545 no 2056 0.399342392665299 2862 2830968 YPR165W RHO1
SGTC_2508 celastrol 40.54 µM -0.255315713604053 0.390833973950824 no 2057 0.39923963216477 2874 122724 Celastrol is a natural product and antioxidant.
SGTC_2101 5377231 179.231 µM -0.256392289728404 0.390415226648023 no 2058 0.39882397042017 2979 2844213
SGTC_789 1309-1135 70.6 µM -0.261546514723298 0.388412197196554 no 2059 0.396835541928321 2846 3092424
SGTC_352 k048-0007 5.11 µM -0.262625151621206 0.387993391740202 no 2060 0.396419756087882 2953 6811911
SGTC_1004 4084-0029 199 µM -0.262930529643575 0.387874845370581 no 2061 0.396302062351837 3025 716894 YLR208W SEC13
SGTC_2610 ononetin 44.17 µM -0.263342017293996 0.387715124250496 no 2062 0.396143488548751 2925 259632
SGTC_130 0136-0219 337.655 µM -0.263427831143588 0.387681817541594 no 2063 0.396110420878748 2827 234244
SGTC_667 1498-1044 59 µM -0.264054425091208 0.387438644307219 no 2064 0.395868990660585 2910 6739982
SGTC_1604 st002052 72.4 µM -0.265779176363971 0.386769518331848 no 2065 0.395204640722887 2995 6254834 YHR062C RPP1
SGTC_868 0527-0199 213 µM -0.266683975476623 0.386418631357106 no 2066 0.39485624646858 2901 2849450
SGTC_1071 trifluoperazine 6.31 µM -0.26692431843708 0.386325440392605 no 2067 0.394763716169979 3025 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1969 st069479 40.1 µM -0.267049242683699 0.38627700465453 no 2068 0.394715623584256 3062 3895485
SGTC_953 1188-0045 9.7 µM -0.267221787776176 0.386210108234832 no 2069 0.39464920084996 2996 6144426
SGTC_2727 riluzole 51.77 µM -0.267561012808876 0.386078599202393 no 2070 0.394518622153594 2875 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3207 9114163 49.47 µM -0.269481344836605 0.385334381849537 no 2071 0.393779648038304 3158 849233
SGTC_2819 7996655 46.38 µM -0.269918488956168 0.385165027189525 no 2072 0.393611481401996 2956 6456960
SGTC_1114 scopoletin 1.73284 µM -0.270046085633067 0.385115598896892 no 2073 0.393562399489995 3013 5280460 A coumarin with genotoxic properties.
SGTC_1644 st010134 20.9 µM -0.270513554872526 0.384934527010444 no 2074 0.393382595121824 2949 3818134
SGTC_1257 0669-0121 16 µM -0.271059974458753 0.384722905906905 no 2075 0.393172452621645 2980 4307855
SGTC_1739 st037196 92.5 µM -0.271067999664141 0.384719798106373 no 2076 0.393169366513225 3063 612214
SGTC_763 3453-1109 128 µM -0.271382849346974 0.384597876855469 no 2077 0.393048295752373 3032 1560353
SGTC_1187 1391-0724 117 µM -0.271622635146107 0.384505030726378 no 2078 0.392956096629587 2911 6997986
SGTC_1669 st015249 58.4 µM -0.273237970771385 0.383879738465429 no 2079 0.392335146816283 2971 722793
SGTC_1281 0884-0031 11.8 µM -0.274434063547683 0.383416928658521 no 2080 0.391875534274918 2896 1548255
SGTC_1482 3346-2049 8.48 µM -0.275745823122643 0.382909554572432 no 2081 0.391371648873549 2978 3826804
SGTC_1271 0832-2808 169 µM -0.276484412551308 0.382623964677451 no 2082 0.391088015105657 3048 3663794
SGTC_3057 9095946 49.47 µM -0.276685225512267 0.382546327488025 no 2083 0.391010908741872 2855 24540043
SGTC_3232 9132874 49.47 µM -0.276840339540614 0.382486361396697 no 2084 0.390951352377759 2895 3784940
SGTC_946 3434-1334 87.4 µM -0.277138333770459 0.382371166640758 no 2085 0.390836944030658 3049 4047976
SGTC_1560 lithocholic acid 53.1 µM -0.277809316775247 0.382111824827696 no 2086 0.390579369428286 2923 9903 A bile acid which acts as a detergent.
SGTC_931 2812-0076 566 µM -0.277914812147245 0.382071054592533 no 2087 0.390538876599656 2870 3450959
SGTC_3119 9125183 49.47 µM -0.278881785012523 0.381697414713316 no 2088 0.390167773819811 2949 22695334
SGTC_1694 st024011 44.9 µM -0.280855039438456 0.380935288227206 no 2089 0.38941079323563 2947 2787533
SGTC_2331 7980721 200 µM -0.281517582629722 0.380679498753287 no 2090 0.38915672208985 2955 2981221
SGTC_84 0443-0269 128.823 µM -0.28170590242796 0.380606803237147 no 2091 0.389084514118176 2916 6150058
SGTC_1854 st056233 32.9 µM -0.281930159352986 0.380520240711703 no 2092 0.388998531673401 3000 5393174
SGTC_2460 5552655 174.22 µM -0.283117505970413 0.380062028123141 no 2093 0.388543381271469 3028 5401989
SGTC_246 cycloheximide 667 µM -0.283925784328121 0.379750199172172 no 2094 0.388233628124107 2894 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2745 rifampicin 24.3 µM -0.287139564313357 0.378511117335147 no 2095 0.387002729578789 2963 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1434 4073-0095 163 µM -0.288702453655304 0.377908991218918 no 2096 0.386404542438174 2944 24133745
SGTC_735 3076-0345 636 µM -0.290044813956046 0.377392063780741 no 2097 0.38589097692136 3077 2888990
SGTC_984 1492-0255 2.91 µM -0.29008339574933 0.377377209620008 no 2098 0.385876219097655 3040 1585198
SGTC_2442 5158906 48.48 µM -0.290513854356331 0.377211493463305 no 2099 0.385711576675775 3053 1893835
SGTC_2594 a-mangostin 100 µM -0.290760952033468 0.377116377044178 no 2100 0.385617075703143 3090 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3315 9136395 68.55 µM -0.291009913475699 0.377020550737729 no 2101 0.385521868811448 3104 16876844
SGTC_2291 7917025 104.35 µM -0.291650934190117 0.376773854037777 no 2102 0.385276763854286 2898 2964612
SGTC_2552 juarezic acid 87.02 µM -0.294214967954478 0.375787590105204 no 2103 0.384296821893677 2894 1549512
SGTC_2965 9082772 38.63 µM -0.294343787300947 0.375738060666562 no 2104 0.384247608180981 3117 16459634
SGTC_2420 aureobasidin a 50 nM -0.294469194582152 0.375689845091462 no 2105 0.384199699794816 3194 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_3228 9131799 49.47 µM -0.295318955339743 0.375363187137512 no 2106 0.383875118824021 2980 17015818
SGTC_1056 3448-1962 115 µM -0.295737326972016 0.375202393007379 no 2107 0.383715344374692 3012 715507
SGTC_1177 0983-0204 23.6 µM -0.296376997631956 0.374956588231076 no 2108 0.383471094939226 3085 766818
SGTC_2808 7946468 45.46 µM -0.296599791891439 0.374870987511066 no 2109 0.383386034885353 3009 2970879
SGTC_364 0083-0097 67.7 µM -0.29711602854478 0.374672665749503 no 2110 0.383188963812793 3062 5207356
SGTC_2670 beta-carotene 100 µM -0.297343899172871 0.374585135616781 no 2111 0.383101984814867 3047 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2203 7227154 166.4 µM -0.29886404127595 0.374001381060581 no 2112 0.382521892364006 2934 896304
SGTC_1929 genistein trimethyl ether 50.5 µM -0.300526956044765 0.373363130748886 no 2113 0.381887619090472 3127 136420
SGTC_673 1082-0474 110 µM -0.300914931679795 0.373214270087378 no 2114 0.381739681949647 2972 3098046
SGTC_3000 9075062 71.4286 µM -0.301038687891717 0.373166790591433 no 2115 0.38169249669021 2960 17057871
SGTC_71 0417-1750 47.813 µM -0.301723776930409 0.37290398868764 no 2116 0.381431320578132 3148 6811472
SGTC_1980 st071811 45.7 µM -0.304149926143869 0.371973787950602 no 2117 0.380506835907342 3081 4974850
SGTC_2301 7769476 200 µM -0.304275931731014 0.371925496975654 no 2118 0.380458840037535 2997 977820
SGTC_3116 9124943 49.47 µM -0.304917513078843 0.37167964557698 no 2119 0.380214488515068 2957 41905195 YPL160W CDC60
SGTC_523 1934-0222 13.7 µM -0.305295327784718 0.371534892970647 no 2120 0.380070617038552 2950 1361595
SGTC_1350 1495-0454 146 µM -0.305569475384593 0.371429869839221 no 2121 0.379966232284061 3108 1069057
SGTC_1885 st057546 99.9 µM -0.306356835651486 0.371128293445672 no 2122 0.379666484730221 3104 702008
SGTC_2647 atorvastatin 60.16 µM -0.306730338344181 0.370985261312123 no 2123 0.379524317763326 3004 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1505 k297-0037 20.6 µM -0.307201733507489 0.370804766889574 no 2124 0.3793449130692 2966 4089396
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.307314182177714 0.37076171515593 no 2125 0.379302120922696 2980 368090
SGTC_1635 st007035 42.4 µM -0.307493942995924 0.370692895872239 no 2126 0.379233716326633 3001 3716403
SGTC_26 0302-0163 425.158 µM -0.308487725717648 0.370312512726397 no 2127 0.378855619300539 2946 3100915
SGTC_224 benfluorex 43.875 µM -0.311234793902083 0.369261697606538 no 2128 0.377811066960799 3055 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_771 0250-0039 27.3 µM -0.312342486678501 0.368838256008403 no 2129 0.377390127134192 2969 3005115
SGTC_568 1193-0097 7.48 µM -0.314458437603394 0.368029826833274 no 2130 0.376586439262876 3053 3646150
SGTC_3138 9097216 49.47 µM -0.316639150298151 0.367197265688594 no 2131 0.375758712755888 2933 25237486
SGTC_471 1-acyl-paf 4 µM -0.317997609470032 0.366678942941492 no 2132 0.375243375117107 2953 16759367
SGTC_495 decylubiquinone 155 µM -0.318170633832671 0.366612942586729 no 2133 0.375177753503294 3032 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_658 3253-0951 102 µM -0.318655520670124 0.36642800292848 no 2134 0.374993873469819 3011 1184878
SGTC_2382 9035899 200 µM -0.318743526430888 0.366394440162369 no 2135 0.374960502743808 2985 6462679
SGTC_2983 9022671 12.99 µM -0.320011299566013 0.365911062895696 no 2136 0.374479882403972 3164 6405161
SGTC_1435 4092-0789 56.7 µM -0.322705078599164 0.364884684486592 no 2137 0.373459302799485 3083 2248285
SGTC_893 0958-0369 48.9 µM -0.322789011087912 0.364852720198608 no 2138 0.373427517897097 3101 6819948
SGTC_2829 7992743 58.44 µM -0.323716651351167 0.364499506485446 no 2139 0.373076281585791 3134 16462845
SGTC_152 4469-0003 551.229 µM -0.324408049620171 0.364236320441408 no 2140 0.37281456314581 2959 697280
SGTC_106 0092-0003 11.579 µM -0.324702149558331 0.364124388445018 no 2141 0.372703253814667 3030 1072148
SGTC_2052 5265182 7.135 µM -0.325917318545402 0.363662028178922 no 2142 0.372243456105372 3142 1239884
SGTC_1141 3253-0389 52.6 µM -0.326957807022424 0.363266289893656 no 2143 0.371849898969452 3083 5402031
SGTC_1377 2944-0135 198 µM -0.327826806768957 0.362935887245817 no 2144 0.371521308759818 3053 1894137
SGTC_1734 st037168 69.4 µM -0.329651855973959 0.362242317060185 no 2145 0.370831517661071 3069 708907
SGTC_323 4013-0906 34.3 µM -0.330167266248297 0.362046528365191 no 2146 0.370636789501909 3073 2910086
SGTC_481 bay k-8644 50 µM -0.332163680592327 0.361288492322406 no 2147 0.369882833467834 2997 2303 A calcium channel antagonist.
SGTC_529 4076-0302 30.3 µM -0.33230027250337 0.361236648404158 no 2148 0.369831267075342 3000 5816522
SGTC_770 0389-1121 67.2 µM -0.333305437161474 0.360855213220958 no 2149 0.369451867778085 3169 6753108
SGTC_1382 3002-2117 298 µM -0.335368319713109 0.360072833904342 no 2150 0.368673631392337 3153 1497314
SGTC_901 1112-0062 60.1 µM -0.335795019233903 0.359911074682523 no 2151 0.368512723195115 2997 1908457
SGTC_368 fentichlor 4.58 µM -0.335887879605815 0.359875875196831 no 2152 0.368477708644234 3057 7329 A pesticide.
SGTC_164 4100-3994 89.624 µM -0.336777119612433 0.359538861693774 no 2153 0.368142461221276 3120 4615967
SGTC_1509 1326-1131 80 µM -0.336952850141917 0.359472274410956 no 2154 0.368076221904485 3112 768313
SGTC_655 k060-0012 42 µM -0.338105196800508 0.35903573649999 no 2155 0.367641957223673 3002 5994525
SGTC_740 k014-0057 261 µM -0.338182659468538 0.359006398286329 no 2156 0.367612771288357 3095 4012779
SGTC_1997 st073024 93.8 µM -0.338363892616887 0.358937761286295 no 2157 0.367544490299805 3141 686268
SGTC_2761 levamisole 97.89 µM -0.338646952840086 0.35883056923336 no 2158 0.367437853551723 3152 26879 An alkaline phosphatase inhibitor.
SGTC_2044 5102272 200 µM -0.340649365459132 0.358072593683202 no 2159 0.366683780744197 3093 592666
SGTC_1793 st048256 72.231 µM -0.340956333408742 0.357956446102776 no 2160 0.366568227488069 2995 672022
SGTC_306 1672-3436 11.6 µM -0.3411902270579 0.357867956497989 no 2161 0.366480190020226 3107 6797378
SGTC_1795 st049545 62.3 µM -0.341326920868491 0.357816244301639 no 2162 0.366428741781738 3130 5291882
SGTC_2709 st078560 56 µM -0.342090950051564 0.357527254951717 no 2163 0.366141223935206 3182 17250903
SGTC_1805 st050013 60.3 µM -0.342717691731689 0.357290254725366 no 2164 0.365905425923681 3046 4037144
SGTC_408 cantharidin 100 µM -0.342919931789202 0.357213790079692 no 2165 0.365829348276529 3036 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2584 androsterone 48.74 µM -0.344515301131794 0.356610800471449 no 2166 0.365229395453099 3136 2754130 A steroid.
SGTC_2268 7933382 153.85 µM -0.346464755522111 0.355874466392246 no 2167 0.364496733465385 2959 935025 YOR257W CDC31
SGTC_63 0099-0242 26.702 µM -0.346470287296155 0.355872377733081 no 2168 0.36449465516557 3152 3898502 YLR359W ADE13
SGTC_906 1165-0455 526 µM -0.34667506249914 0.355795062796057 no 2169 0.364417723469633 3010 3252859
SGTC_1466 k213-0079 57.5 µM -0.348047843180603 0.355276908945429 no 2170 0.363902126669696 3023 3657981
SGTC_183 3914-0051 30.55 µM -0.34885580865669 0.354972068640888 no 2171 0.363598781468349 3155 1596232
SGTC_2880 9042983 58.44 µM -0.349436126278482 0.354753175703798 no 2172 0.363380957864497 3144 6464714
SGTC_1788 fluconazole 20 µM -0.349566727079991 0.354703920334144 no 2173 0.363331942628107 3121 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1060 3448-7350 82 µM -0.349630614153108 0.354679826562714 no 2174 0.36330796625495 3143 570178
SGTC_590 k048-0076 22.4 µM -0.350553150463537 0.354331974723589 no 2175 0.36296180455434 3136 6832814
SGTC_2180 6301957 200 µM -0.351329488769594 0.354039342469956 no 2176 0.362670587195351 3158 845462
SGTC_155 k072-0202 43.6 µM -0.352622956741138 0.353551975326822 no 2177 0.362185562399416 3096 5857737
SGTC_2862 9027634 71.43 µM -0.352719397606049 0.353515646876887 no 2178 0.362149407842063 2990 5012562
SGTC_3043 9092303 49.47 µM -0.353561763782654 0.353198391492331 no 2179 0.361833666887033 3079 25236084
SGTC_634 1611-4317 11.2 µM -0.353756625787908 0.353125016288071 no 2180 0.361760640875864 3129 2843522
SGTC_2680 butyl paraben 22.24 µM -0.354521553447178 0.352837035918392 no 2181 0.361474027133354 3081 7184 An antifungal and steroid mimetic.
SGTC_3275 9138069 49.47 µM -0.355335143952593 0.352530827442324 no 2182 0.361169265009306 3127 17617007
SGTC_841 0251-0215 91.2 µM -0.355694081606352 0.352395765577404 no 2183 0.361034838876574 3090 3888614
SGTC_2271 7849410 118.62 µM -0.356643281201477 0.352038688344507 no 2184 0.360679435837356 3179 972430
SGTC_895 0964-0006 13.7 µM -0.356662268172515 0.352031547008747 no 2185 0.360672327887362 3159 6738897
SGTC_2848 9016370 25.97 µM -0.356820395884092 0.351972074405959 no 2186 0.360613133171161 3157 7894410
SGTC_2549 cedrol 20.94 µM -0.357785083758308 0.351609329075345 no 2187 0.360252077048156 3173 6708665 A sedative which affects the nervous system.
SGTC_3346 9158254 43.5805 µM -0.358928577889767 0.351179523350242 no 2188 0.35982426006633 3129 17639500
SGTC_639 0833-0042 114 µM -0.360311581650263 0.350659947288092 no 2189 0.35930706963425 3063 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3044 9093193 49.47 µM -0.361012572357347 0.350396700997027 no 2190 0.359045024302071 3138 25236277
SGTC_1363 1636-0063 10.4 µM -0.361781716654247 0.350107943333852 no 2191 0.358757577993068 3070 6072185
SGTC_354 2783-3500 4.88 µM -0.362187008213756 0.349955820717851 no 2192 0.358606143698803 3053 6740761
SGTC_521 r062-0005 13.8 µM -0.363116370856665 0.349607083584173 no 2193 0.358258977948467 3014 2832033
SGTC_598 3937-0236 20.2 µM -0.365362810089023 0.348764646731672 no 2194 0.357420299210062 3116 1379313
SGTC_3101 9120531 49.47 µM -0.365380319489363 0.348758083455119 no 2195 0.35741376500187 3251 24824904
SGTC_281 1672-3440 14.9 µM -0.365560707694005 0.348690468830606 no 2196 0.357346449648865 3147 6833000
SGTC_2814 7977482 42.97 µM -0.365665311553623 0.348651262533175 no 2197 0.357307416725464 3197 6456762
SGTC_981 1488-1094 54.9 µM -0.367148842500087 0.348095398401082 no 2198 0.356753998160266 2994 3449522
SGTC_565 1418-0001 44.5 µM -0.367163009929546 0.34809009157837 no 2199 0.356748714572544 3213 2862145
SGTC_2993 9054257 71.4286 µM -0.368987236890286 0.34740702317532 no 2200 0.356068619030158 3012 6470217 YGL055W OLE1
SGTC_2655 perillic acid 100 µM -0.369754428078802 0.347119901871021 no 2201 0.355782736761527 3065 5702197 An apoptosis inducer.
SGTC_1202 1988-0068 29.6 µM -0.369776602594983 0.347111604362099 no 2202 0.355774474966262 3055 2850480
SGTC_3313 9133968 57.047 µM -0.370900799538542 0.346691035882763 no 2203 0.355355709810061 3051 1494643
SGTC_1798 st045719 60.953 µM -0.370961030736188 0.346668508374641 no 2204 0.355333278515866 3152 3980186
SGTC_2561 acetosyringone 100 µM -0.374581010486929 0.345315571482392 no 2205 0.353986048948069 3027 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_595 3909-8003 73.7 µM -0.374811100521802 0.34522964382502 no 2206 0.353900479048035 3176 699517
SGTC_3020 9089140 49.47 µM -0.374857206285839 0.34521242647982 no 2207 0.353883333318756 3161 17217859
SGTC_85 0868-0259 160.055 µM -0.3756797287596 0.344905324536019 no 2208 0.353577504956414 3114 83173
SGTC_134 0269-0018 6.916 µM -0.3768491539667 0.344468876782978 no 2209 0.353142854750159 3126 4378915
SGTC_910 3454-3003 490 µM -0.376975300225442 0.344421809387383 no 2210 0.353095980332066 3206 820824
SGTC_1698 5-fluorocytosine 1.055 µM -0.377246789634882 0.344320520069401 no 2211 0.35299510572563 3195 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1632 st005650 90 µM -0.379313380261292 0.343549867263718 no 2212 0.352227582384426 3164 2759605
SGTC_730 1436-0052 41.2 µM -0.379436445943173 0.343503995281639 no 2213 0.352181895237211 3091 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2224 6650123 117.647 µM -0.380449906062178 0.343126321902895 no 2214 0.351805737474516 3108 2908370
SGTC_1231 0242-0792 125 µM -0.381317909040205 0.342802978715835 no 2215 0.351483683127775 3061 3707635
SGTC_13 0199-0087 65 µM -0.381478863733849 0.342743033498238 no 2216 0.351423975963324 3099 4589825
SGTC_1237 0330-0133 46.1 µM -0.38163435954766 0.342685125120686 no 2217 0.35136629728652 3042 X1237 YHR072W ERG7
SGTC_2867 9039098 71.43 µM -0.383474438711543 0.342000140116828 no 2218 0.350684009675664 3040 6463460
SGTC_46 0329-0187a 2.197 µM -0.383827459417008 0.341868784527128 no 2219 0.350553167196843 3167 46494817
SGTC_1897 st060201 15 µM -0.384195254252388 0.341731951985302 no 2220 0.350416867737633 3098 611878
SGTC_1092 toremifene 6.32 µM -0.384212910778324 0.341725383663042 no 2221 0.350410324968212 3067 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_207 4185-0010 4.486 µM -0.384556926859079 0.341597417401939 no 2222 0.350282855868205 3166 3761753
SGTC_2826 7992541 19.48 µM -0.384612693968778 0.341576675003049 no 2223 0.350262193935816 3075 2985066
SGTC_1470 k295-0292 231 µM -0.388421565537495 0.340161112489021 no 2224 0.348852043802985 3196 5045612
SGTC_2481 5478948 45.16 µM -0.388797028886669 0.340021693495535 no 2225 0.348713149431078 3231 77792
SGTC_1909 st060837 51.5 µM -0.38883080937239 0.340009151023061 no 2226 0.348700654080453 3096 678937
SGTC_2366 9070441 60.58 µM -0.390258588953732 0.339479187901598 no 2227 0.348172670790914 3084 6837235
SGTC_2027 5150920 200 µM -0.391051520892623 0.339185004440094 no 2228 0.347879576857586 3134 786715
SGTC_3318 9139014 38.6185 µM -0.393841484183727 0.338150688078875 no 2229 0.346849037305383 3085 16643984
SGTC_1663 st014140 55.4 µM -0.393937060939132 0.338115276715338 no 2230 0.346813753759494 3153 4207120
SGTC_1774 st048371 48.465 µM -0.396112036765856 0.337309831837833 no 2231 0.346011189494602 3070 4242727
SGTC_2223 6903751 107.57 µM -0.396867143665841 0.337030371965267 no 2232 0.345732717143143 3176 5598863
SGTC_2065 5221596 34.26 µM -0.397514901386859 0.336790712933307 no 2233 0.345493900078964 3224 788581
SGTC_1552 6-methylflavone 10.6 µM -0.398045166359279 0.336594573478558 no 2234 0.345298446323044 3209 689013
SGTC_19 0279-0214 38.434 µM -0.398138654319755 0.336559997869408 no 2235 0.345263991274111 3120 3566274 YBR002C RER2
SGTC_722 3534-0461 190 µM -0.400937956518309 0.335525344550888 no 2236 0.344232901851658 3132 658262
SGTC_1352 1496-0991 99 µM -0.401532235204693 0.335305852588525 no 2237 0.344014155022094 3093 3000039
SGTC_2782 7736369 71.43 µM -0.403709920258595 0.334502023320976 no 2238 0.343213021902671 3133 2950836 YOL077C BRX1
SGTC_2371 9071574 200 µM -0.404056526054584 0.334374153683236 no 2239 0.34308557641402 3222 45596039
SGTC_2430 5571206 200 µM -0.405045047239912 0.334009574525856 no 2240 0.342722199423246 3267 1731771
SGTC_3227 9130768 49.47 µM -0.406017092496666 0.333651224590452 no 2241 0.34236502077445 3124 17720899
SGTC_1331 1472-0049 76.2 µM -0.409603216995635 0.332330494006259 no 2242 0.341048518336821 3074 24051409
SGTC_3345 9148410 3.559 µM -0.409941986186126 0.332205836248123 no 2243 0.34092425242847 3240 4903596
SGTC_2912 7964298 10.93 µM -0.410478842552584 0.332008325872457 no 2244 0.340727360350807 3206 2975850
SGTC_3230 9131665 49.47 µM -0.411122673333542 0.331771520971647 no 2245 0.340491292622038 3118 15943720
SGTC_1425 4048-4433 7.33 µM -0.411952975228847 0.331466230076163 no 2246 0.340186945433754 3223 23734946
SGTC_1651 st011928 86.1 µM -0.413583397599307 0.330867071460883 no 2247 0.339589617078936 3228 720198
SGTC_544 k015-0020 52.4 µM -0.413592740592096 0.330863639281144 no 2248 0.33958619530008 3164 3008304
SGTC_2097 5376186 200 µM -0.415489976436417 0.33016697824032 no 2249 0.338891625708711 3231 742755
SGTC_564 3555-0129 330 µM -0.416221548413821 0.329898503589174 no 2250 0.33862394656096 3190 563260
SGTC_334 1502-1024 68.5 µM -0.41673125928923 0.329711500011583 no 2251 0.338437493632228 3232 3296216
SGTC_287 k060-0039 29.6 µM -0.417533310956281 0.329417328149983 no 2252 0.338144182244466 3269 5861974
SGTC_23 0213-0011 39.996 µM -0.418115440472375 0.329203884150789 no 2253 0.337931358185551 3301 627608
SGTC_170 4197-0004 226 µM -0.418226185386798 0.329163284645601 no 2254 0.337890876181116 3244 218692
SGTC_2491 paeonol 100 µM -0.420945953338214 0.328166840745168 no 2255 0.336897274084088 3098 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1511 0906-3109 28.5 µM -0.42289325486272 0.327454155945629 no 2256 0.336186572150614 3170 2882180
SGTC_2113 5491891 107.031 µM -0.423765599150734 0.327135093914475 no 2257 0.335868384370955 3196 789979
SGTC_3190 9110366 49.47 µM -0.424263539614604 0.326953027587684 no 2258 0.335686813182407 3227 17123768
SGTC_1660 st012960 28.1 µM -0.427267653099105 0.325855482320478 no 2259 0.334592195122815 3233 24207266
SGTC_1181 1222-0449 220 µM -0.427894484484996 0.325626660826286 no 2260 0.334363971431405 3310 658318
SGTC_1914 st062367 72.6 µM -0.431123928014659 0.324448812092866 no 2261 0.333189131542165 3145 978205
SGTC_139 0099-0334 718.624 µM -0.432046698097543 0.324112579329695 no 2262 0.332853736655919 3177 97690
SGTC_486 niguldipine 82 µM -0.432544442558319 0.32393127407128 no 2263 0.3326728793161 3150 1236 A calcium channel blocker.
SGTC_706 4262-0057 46.9 µM -0.432929466625855 0.323791056276558 no 2264 0.33253300606388 3155 883298
SGTC_482 fipronil 114 µM -0.433257013516246 0.323671790163691 no 2265 0.332414031727705 3230 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2416 tofa 880 nM -0.433748218549594 0.323492966919432 no 2266 0.332235643750879 3137 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2448 5185112 27.17 µM -0.433909901736733 0.323434115051929 no 2267 0.332176934551992 3270 5718189
SGTC_389 tpck 16.7 µM -0.434507725358843 0.32321654862733 no 2268 0.331959893053625 3223 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1362 1611-0397 101 µM -0.434755192113912 0.323126505542075 no 2269 0.331870066065838 3181 27816
SGTC_1491 4138-0063 26.5 µM -0.435757606898372 0.322761873631174 no 2270 0.331506302352113 3252 23883227
SGTC_3244 9134489 49.47 µM -0.437277055858625 0.3222094935818 no 2271 0.330955216438212 3240 16584271
SGTC_1216 1165-0504 9.65 µM -0.438179781327806 0.321881502761936 no 2272 0.330627982002936 3294 6304004
SGTC_979 1426-2828 121 µM -0.438361434496033 0.32181551875518 no 2273 0.330562149077305 3305 747872
SGTC_365 0121-0052 13.6 µM -0.438714775070501 0.321687186817618 no 2274 0.330434109934552 3284 3101739
SGTC_1508 1080-0625 72.9 µM -0.440823883519953 0.320921609622956 no 2275 0.329670250804688 3237 767111
SGTC_230 MPP+ 141.667 µM -0.440857211160008 0.320909518248113 no 2276 0.329658186170759 3228 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2258 7960471 200 µM -0.440931512671614 0.320882562104865 no 2277 0.329631289598758 3229 2974708
SGTC_1340 1486-1359 257 µM -0.441463607171549 0.320689549007173 no 2278 0.329438701266206 3193 4309068
SGTC_2825 7998094 58.44 µM -0.441793360759067 0.320569957807069 no 2279 0.329319371682561 3197 2987815
SGTC_2843 9000894 45.46 µM -0.442296260953526 0.320387607671342 no 2280 0.329137418142378 3213 2242070
SGTC_3294 9122953 26.2835 µM -0.442510910271013 0.320309789657689 no 2281 0.329059768525628 3173 16459826
SGTC_1972 st070201 17.4 µM -0.443065069415847 0.320108923791118 no 2282 0.32885933497669 3297 2829099
SGTC_2772 vinpocetine 57.06 µM -0.443902012799132 0.31980565716191 no 2283 0.328556714628531 3365 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2438 5259590 200 µM -0.44452714734778 0.319579218057854 no 2284 0.328330753031193 3261 1201127
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.446705742362182 0.318790603363685 no 2285 0.327543767581799 3196 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_889 0919-1524 82.7 µM -0.447104361405192 0.318646398608912 no 2286 0.327399855066808 3257 3905452
SGTC_2204 7233102 200 µM -0.447727282300051 0.318421105223305 no 2287 0.327175014731102 3192 2172480
SGTC_1063 disulfiram 1.84 µM -0.448320753932711 0.318206525269842 no 2288 0.326960862288319 3216 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_596 1155-0152 116 µM -0.450111147790977 0.317559547139037 no 2289 0.326315149514646 3227 280313
SGTC_586 0957-0265 8.15 µM -0.450119301526032 0.317556601971219 no 2290 0.326312210025753 3256 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1671 st016596 74.5 µM -0.450616697513386 0.317376962022403 no 2291 0.326132915068572 3257 2829167
SGTC_199 4063-0024 41.6 µM -0.450759537061527 0.317325381919242 no 2292 0.326081433516263 3299 306215
SGTC_448 monastrol 171 µM -0.453195911547015 0.316446141418846 no 2293 0.325203838100758 3243 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2845 9003024 42.97 µM -0.453821400655754 0.316220581478205 no 2294 0.32497868957004 3392 2990173
SGTC_1236 0330-0013 258 µM -0.454375273090362 0.31602090456324 no 2295 0.324779373231265 3199 4617066
SGTC_2978 9011784 42.97 µM -0.45483970269243 0.315853514099747 no 2296 0.324612282416426 3265 2994934
SGTC_372 0155-0182 15.9 µM -0.455800005530028 0.315507519981929 no 2297 0.324266900074067 3194 771486
SGTC_591 4299-0174 154 µM -0.45590536844509 0.315469567889816 no 2298 0.324229014464128 3222 5509088
SGTC_584 0986-0246 15.4 µM -0.456918819489213 0.315104618719677 no 2299 0.323864698292459 3334 53315 YDR232W HEM1
SGTC_329 k048-0121 21.3 µM -0.457432199069063 0.314919816787431 no 2300 0.323680212541806 3280 6832902
SGTC_1409 3909-8004 61.9 µM -0.457773996597922 0.314796805162062 no 2301 0.323557409755377 3254 2119279
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.458858253964268 0.314406721099112 no 2302 0.323167979351215 3234 688664
SGTC_1824 st053723 68.6 µM -0.458947531154292 0.314374611003656 no 2303 0.323135922479755 3256 675225
SGTC_1140 3229-1848 2.98 µM -0.45901114170276 0.314351733219431 no 2304 0.323113082562453 3300 2849525
SGTC_2697 mebhydrolin 72.4 µM -0.459116437190983 0.314313864849593 no 2305 0.323075276772798 3363 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_258 haloperidol 50.781 µM -0.461020884353602 0.313629288897029 no 2306 0.322391810846283 3236 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_422 cantharidin 155 µM -0.461071625608886 0.313611058116429 no 2307 0.322373609074584 3157 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1280 0880-0253 10.1 µM -0.461337962141594 0.313515373766261 no 2308 0.32227807650776 3230 6836607
SGTC_3218 9131285 49.47 µM -0.462172675791868 0.313215574945991 no 2309 0.321978748140548 3392 17156417
SGTC_1692 fluoroquinolonic acid 71 µM -0.464696732657073 0.31230977685132 no 2310 0.321074324256282 3325 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2017 5132927 60.65 µM -0.465156620738786 0.312144860552394 no 2311 0.320909650511551 3194 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_190 3970-0790 3.722 µM -0.465184937307775 0.312134707433861 no 2312 0.320899512248874 3287 2832352
SGTC_1410 3909-8106 77.9 µM -0.466128746116094 0.311796379374143 no 2313 0.320561674109672 3312 1039210
SGTC_1100 amiodarone 5.07 µM -0.466360198681882 0.31171343457926 no 2314 0.320478847907378 3326 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_654 1124-0271 80.9 µM -0.467018795104153 0.311477468096428 no 2315 0.320243215534838 3230 5403748
SGTC_55 0767-0285 6.563 µM -0.467607594545572 0.311266574497601 no 2316 0.3200326164481 3326 3116166
SGTC_1014 4130-3005 69.3 µM -0.468219426718938 0.311047496748846 no 2317 0.319813840541964 3195 743608
SGTC_3301 9125354 19.7965 µM -0.469189133943073 0.310700412401909 no 2318 0.319467225844811 3281 41905162
SGTC_1211 1056-0033 32.3 µM -0.469605865062033 0.310551304822557 no 2319 0.319318316801786 3341 6741922
SGTC_1713 st033146 12.748 µM -0.471244455554614 0.309965314420811 no 2320 0.318733087839323 3370 674619
SGTC_575 k072-0246 11.9 µM -0.471970268662637 0.309705904244501 no 2321 0.318474005155724 3290 6796779
SGTC_1657 st012939 43.4 µM -0.472691206768598 0.309448330216661 no 2322 0.31821675047341 3348 24207257
SGTC_854 0422-0053 192 µM -0.474360223054441 0.30885238968426 no 2323 0.317621526502228 3324 3596728
SGTC_1036 k216-0215 33.5 µM -0.474477313190096 0.308810600230067 no 2324 0.317579786126176 3280 622330
SGTC_656 4090-1979 187 µM -0.475803539846646 0.308337443005737 no 2325 0.317107173875505 3355 22330961
SGTC_2675 theaflavin digallate 100 µM -0.475953049023405 0.308284122636187 no 2326 0.317053913684617 3313 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_902 1120-0002 2.07 µM -0.476019915345532 0.308260277000835 no 2327 0.317030094881034 3297 3280475
SGTC_3048 9093155 49.47 µM -0.476077996903828 0.308239564814059 no 2328 0.317009405959556 3338 25236002
SGTC_2941 9056145 11.23 µM -0.476419702175075 0.308117723294677 no 2329 0.316887700535846 3299 2119517
SGTC_1771 st048882 4.1505 µM -0.47681597561399 0.307976450933608 no 2330 0.316746584337203 3216 4580403
SGTC_256 clotrimazole 625 nM -0.47832872348243 0.307437414719593 no 2331 0.316208127803972 3283 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1143 3454-2408 5.08 µM -0.478494531629009 0.307378357691497 no 2332 0.316149132726976 3310 X1143
SGTC_2741 miltefosine 3.04 µM -0.47911360960843 0.307157900569222 no 2333 0.315928904142637 3232 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_22 0964-0034 14.468 µM -0.47940248138808 0.307055055555512 no 2334 0.315826164273875 3293 138402
SGTC_2109 5483026 200 µM -0.479610264801178 0.306981089254589 no 2335 0.315752273014949 3264 759335
SGTC_2918 7977171 22.06 µM -0.479664910353151 0.306961637950808 no 2336 0.315732841364966 3279 2236483
SGTC_3096 9117468 49.47 µM -0.483581089533392 0.305569075736365 no 2337 0.314341599051719 3317 41316311
SGTC_2128 5255449 168.493 µM -0.483816890399393 0.305485316251695 no 2338 0.314257913464306 3235 736008
SGTC_1248 0469-0687 58.6 µM -0.486248034415138 0.304622336972585 no 2339 0.31339565915669 3337 4017482
SGTC_2053 5265679 138 µM -0.486724082853629 0.304453481849196 no 2340 0.313226938112077 3235 764595
SGTC_2396 5342950 42.78 µM -0.487237478078649 0.304271426464017 no 2341 0.313045024432625 3300 1886677
SGTC_3137 9097352 49.47 µM -0.487291251100296 0.304252360786269 no 2342 0.313025973423527 3489 44120435
SGTC_3031 9088762 49.47 µM -0.487796085460577 0.304073393464927 no 2343 0.312847142209877 3210 205253
SGTC_1169 aniline yellow 25.8 µM -0.489554965336472 0.303450225058124 no 2344 0.312224425350976 3266 6051 A DNA damaging agent.
SGTC_631 k072-0230 41.5 µM -0.492076965258795 0.302557681433547 no 2345 0.31133246775309 3329 5773147
SGTC_752 1896-0090 130 µM -0.492256722426185 0.302494109758687 no 2346 0.31126893508481 3337 772567
SGTC_3216 9129716 49.47 µM -0.49427286863206 0.301781504110532 no 2347 0.310556741752498 3257 8056934
SGTC_3086 9117350 49.47 µM -0.494796282588254 0.30159662722173 no 2348 0.310371964346621 3299 2679265
SGTC_2796 7949634 45.45 µM -0.494952140590789 0.301541585912591 no 2349 0.310316952058759 3284 2971588
SGTC_3240 9133527 49.47 µM -0.495930812854611 0.301196070790962 no 2350 0.309971612856672 3281 17617455
SGTC_3017 9080681 49.47 µM -0.496017825445887 0.301165360085975 no 2351 0.309940917265341 3329 16451914
SGTC_2711 st079103 59.1 µM -0.496942901238183 0.300838945990466 no 2352 0.309614658529074 3283 54693780
SGTC_2519 cryptotanshinone 88.04 µM -0.497339517891081 0.300699048225547 no 2353 0.309474824393395 3393 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.498394480306025 0.300327076525556 no 2354 0.309103013238534 3357 688662
SGTC_3336 9143619 71.43 µM -0.500395864016224 0.299621975996635 no 2355 0.308398182527382 3390 45595730
SGTC_3344 9148862 3.898 µM -0.501186550288554 0.299343618915412 no 2356 0.308119919502736 3420 4905352
SGTC_1220 1838-0075 193 µM -0.502297470176795 0.298952723512799 no 2357 0.307729144253278 3312 5529645
SGTC_3271 9137798 49.47 µM -0.503072231426043 0.298680248350255 no 2358 0.307456744590885 3350 6498326
SGTC_2447 5741742 33.78 µM -0.503541550970287 0.298515248669316 no 2359 0.307291787330226 3366 1776504
SGTC_3183 9108214 49.47 µM -0.503744739906812 0.298443825963044 no 2360 0.307220382213863 3328 4974831
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.506742162770155 0.297391110079948 no 2361 0.306167871370119 3375 165521
SGTC_302 1094-0063 18.9 µM -0.508117493231736 0.296908652741796 no 2362 0.305685473992144 3265 5440289
SGTC_1801 st050089 28.441 µM -0.508617909459333 0.296733198757058 no 2363 0.305510036500501 3376 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_748 act1.228 77.9 µM -0.509117760981809 0.296557990173397 no 2364 0.305334841556176 3335 4421505 YNR035C ARC35
SGTC_2952 9073731 13.78 µM -0.511965599195919 0.295560667856411 no 2365 0.304337542902465 3306 16457353
SGTC_800 3448-7362 155 µM -0.512128615123266 0.295503625833652 no 2366 0.304280499452597 3417 15991913
SGTC_483 fpl-64176 144 µM -0.512321330056444 0.295436198158779 no 2367 0.30421306970219 3393 3423
SGTC_2790 5423970 71.43 µM -0.513273230683229 0.295103248191757 no 2368 0.303880103310409 3417 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1849 st056239 19.2 µM -0.513280068020191 0.295100857295122 no 2369 0.303877712258663 3265 5393181
SGTC_710 3448-4187 58 µM -0.514014061254519 0.294844244652791 no 2370 0.303621079885089 3396 3946412
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.514095991417094 0.294815607289767 no 2371 0.303592439940997 3446 165506
SGTC_102 gallobenzophenone 83.616 µM -0.515753611933275 0.294236488468035 no 2372 0.303013252570355 3445 70837
SGTC_2488 5268135 45.7 µM -0.516189746185466 0.294084204678857 no 2373 0.302860945575344 3388 1270356 YLR208W SEC13
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.516329761580352 0.294035323616868 no 2374 0.302812056606771 3288 6857784
SGTC_1567 st069303 68.4 µM -0.517462876453709 0.293639877818907 no 2375 0.302416538657533 3388 5581319
SGTC_1128 3448-9350 235 µM -0.517901526543432 0.293486859437774 no 2376 0.302263488443603 3327 619386
SGTC_363 0455-0021 3.06 µM -0.518082964841257 0.293423577432138 no 2377 0.302200192634408 3368 4597466
SGTC_3100 9120536 49.47 µM -0.519574204140497 0.292903703000387 no 2378 0.301680190640126 3329 16421196
SGTC_775 4577-0580 57.3 µM -0.519813496238124 0.292820321034903 no 2379 0.301596785862985 3487 2006902
SGTC_157 1348-1695 65.819 µM -0.520516905125035 0.292575280174256 no 2380 0.301351674196584 3399 5380510
SGTC_1469 k284-2957 126 µM -0.520773926363389 0.292485767539808 no 2381 0.301262134294317 3348 23884841
SGTC_3130 9127414 49.47 µM -0.520839604153628 0.29246289601681 no 2382 0.301239255683617 3381 1494646
SGTC_516 3992-2719 87.3 µM -0.521177455556698 0.29234525635328 no 2383 0.301121578789637 3225 5350887 YDR037W KRS1
SGTC_2220 6782180 200 µM -0.5211792774283 0.292344622038295 no 2384 0.301120944270386 3352 833803
SGTC_1898 st060199 18.6 µM -0.521415617832338 0.292262341611916 no 2385 0.301038637027772 3365 688866
SGTC_1952 st077036 64.1 µM -0.521687444142026 0.292167720312367 no 2386 0.30094398410473 3394 2937007
SGTC_1080 nisoldipine 24.4 µM -0.523453315793679 0.291553377108542 no 2387 0.300329415127277 3276 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1024 4507-0395 26 µM -0.523487412815483 0.29154152075321 no 2388 0.300317554065695 3473 4201836
SGTC_583 1488-1091 88.9 µM -0.524645776692345 0.291138863383116 no 2389 0.299914729008731 3431 4303273
SGTC_2677 mitomycin C 100 µM -0.525472819613239 0.290851535059335 no 2390 0.299627271686142 3388 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_967 1306-0166 352 µM -0.525483903871232 0.290847685105987 no 2391 0.299623419951454 3415 4437607
SGTC_2390 9097792 176.6 µM -0.528557875711286 0.289780906974004 no 2392 0.298556094268978 3336 4497149
SGTC_817 1391-0715 46 µM -0.528937950500758 0.289649135060467 no 2393 0.298424247246169 3336 1353946
SGTC_3147 9097027 49.47 µM -0.529669724717518 0.289395508209061 no 2394 0.298170471193979 3325 25236841
SGTC_2424 5537928 59.2 µM -0.531881901996959 0.288629421125967 no 2395 0.297403896346319 3347 5382802
SGTC_2957 9076800 11.52 µM -0.531995675797405 0.288590046581653 no 2396 0.297364495224066 3335 16459615
SGTC_613 3914-0030 117 µM -0.532599442019663 0.288381139077043 no 2397 0.297155444236037 3239 1145395
SGTC_143 4032-1194 15.74 µM -0.533106351382787 0.288205799824756 no 2398 0.296979981345429 3395 1806963
SGTC_1638 st008370 60.6 µM -0.533206400050498 0.288171199071273 no 2399 0.296945355847303 3416 24207134
SGTC_1135 dihydrocapsaicin 536.708 nM -0.534542141214716 0.287709435237336 no 2400 0.296483250845823 3372 107982 A Capsaicinoid.
SGTC_1665 st014639 11.4 µM -0.535612512254412 0.287339662005658 no 2401 0.296113189721321 3455 981133 YIL048W NEO1
SGTC_2004 4023728 41.89 µM -0.536139239667604 0.287157779934337 no 2402 0.295931161242196 3458 360084 YDR527W RBA50
SGTC_2625 euphol 100 µM -0.536246963304246 0.287120589043731 no 2403 0.295893940024275 3451 6708538 A triterpene alcohol.
SGTC_900 1112-0045 141 µM -0.536260371131708 0.28711596023739 no 2404 0.295889307434101 3365 56211 YIL048W NEO1
SGTC_3341 9147222 25.867 µM -0.536979818259319 0.286867636150011 no 2405 0.2956407773435 3433 1939759
SGTC_217 ketoconazole 989 nM -0.538818488859544 0.286233464173354 no 2406 0.295006052424515 3380 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_14 0354-0009 295 µM -0.540148745578183 0.285775063628549 no 2407 0.294547228122719 3394 1713507
SGTC_1946 st076057 65.1 µM -0.540296261344025 0.285724251866781 no 2408 0.294496368143741 3346 953009
SGTC_2570 licareol 100 µM -0.543266853176375 0.284701948199811 no 2409 0.293473041452509 3370 443158
SGTC_231 b-estradiol 524 µM -0.54668677488806 0.283527178047664 no 2410 0.292296970807711 3320 450 A steroid.
SGTC_727 3032-0951 202 µM -0.546906975108071 0.283451617200925 no 2411 0.292221321727812 3381 3652836
SGTC_1453 4237-0541 195 µM -0.54732309204329 0.283308854657774 no 2412 0.292078390963581 3423 739892
SGTC_2452 5863136 48.41 µM -0.547740642941754 0.283165634815938 no 2413 0.291935000368888 3389 2184096
SGTC_29 0299-0004 12.984 µM -0.54870822186137 0.282833889092487 no 2414 0.291602851450534 3357 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1002 4049-0206 172 µM -0.55138996481274 0.281915399190441 no 2415 0.290683189210381 3400 4662749
SGTC_670 4204-0025 119 µM -0.552755041545809 0.281448416554535 no 2416 0.290215578885857 3435 719039
SGTC_702 1488-0190 94 µM -0.5533290003119 0.281252181033016 no 2417 0.2900190732177 3449 949357
SGTC_923 1900-2434 73.3 µM -0.55358735138434 0.281163872807807 no 2418 0.289930642190499 3425 5910570
SGTC_2428 5615643 7.78 µM -0.553738348119287 0.281112266087374 no 2419 0.289878963350972 3430 2253075
SGTC_2705 st078069 42.8 µM -0.554045456199816 0.281007318725641 no 2420 0.289773868521132 3403 1530061
SGTC_2078 5212016 200 µM -0.555270438421889 0.280588896741973 no 2421 0.289354847824281 3412 1899708
SGTC_66 0109-0187 42.4 µM -0.555322483428524 0.280571126203207 no 2422 0.289337051476713 3480 759417
SGTC_2377 9073351 62.6 µM -0.555796691746316 0.280409234950003 no 2423 0.289174923671252 3363 7337946 YHR072W ERG7
SGTC_3164 9100705 49.47 µM -0.556608661087433 0.280132139614682 no 2424 0.288897417458453 3493 17174235
SGTC_404 fumagillin 50 µM -0.556613607530905 0.280130451981784 no 2425 0.288895727299943 3413 12015870 A methionine aminopeptidase binder.
SGTC_2339 9000433 200 µM -0.55827024230372 0.279565516870267 no 2426 0.288329930944987 3363 2988954
SGTC_2121 5257820 149.641 µM -0.558694108244572 0.279421061703142 no 2427 0.288185250494668 3493 791256
SGTC_1102 cgs 12066b 26.1 µM -0.558893010426201 0.279353287563597 no 2428 0.288117369947648 3411 6438352 A 5-HT1B full agonist.
SGTC_1738 st035555 74 µM -0.559203449110601 0.279247524320488 no 2429 0.288011439745116 3444 5331140
SGTC_2736 butenafine 14.65 µM -0.559283614805612 0.279220215860637 no 2430 0.287984087995916 3381 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1741 st038134 10.228 µM -0.559640685323538 0.27909859548699 no 2431 0.287862273933212 3553 1272587
SGTC_455 paf C-16 10 µM -0.560376017867278 0.278848217953174 no 2432 0.287611493042692 3429 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_27 0485-0001 32.618 µM -0.560637744974147 0.278759127393806 no 2433 0.287522257460202 3423 2054479
SGTC_3040 9091894 49.47 µM -0.560684725403631 0.27874313696438 no 2434 0.287506240917973 3387 25236966
SGTC_2920 7982904 15.77 µM -0.560874889417409 0.278678416612576 no 2435 0.28744141461703 3406 6456808
SGTC_2515 chrysin 20.77 µM -0.561811638155529 0.278359710718108 no 2436 0.287122180927884 3433 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1337 1486-1011 40.3 µM -0.56208108513939 0.278268070867115 no 2437 0.287030387449028 3478 X1337
SGTC_1049 3226-0134 66 µM -0.562609794260862 0.278088297823659 no 2438 0.286850310603787 3467 5702385
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.562699916901004 0.278057659743064 no 2439 0.286819620426839 3492 5282362
SGTC_2560 caryophyllene 100 µM -0.563297778063345 0.27785445265146 no 2440 0.286616065442339 3406 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_607 4491-0986 66.8 µM -0.564109420094479 0.277578699628794 no 2441 0.286339833752679 3500 698981 YDR232W HEM1
SGTC_2885 9057732 51.95 µM -0.564196885853195 0.277548991374631 no 2442 0.286310073477266 3499 6471414
SGTC_313 3474-0040 5.03 µM -0.564297719480353 0.277514744574316 no 2443 0.286275766599227 3420 1043375 YIL048W NEO1
SGTC_2319 6033012 152.6 µM -0.564814370730575 0.277339303255567 no 2444 0.286100015677062 3345 847246
SGTC_1940 st075990 51.1 µM -0.565902467432864 0.2769699914174 no 2445 0.285730042071614 3574 1084979
SGTC_1797 st048695 56.8 µM -0.565994562418886 0.27693874443366 no 2446 0.285698738471612 3449 592262 YIL048W NEO1
SGTC_3193 9111931 49.47 µM -0.566031923451509 0.276926068670245 no 2447 0.285686039713224 3426 17087244
SGTC_1430 4049-0248 69.1 µM -0.566438590420952 0.276788114033519 no 2448 0.285547833775849 3494 22774488
SGTC_2802 7925815 54.55 µM -0.568329332656765 0.276147155366042 no 2449 0.284905682547447 3400 1262923
SGTC_3016 9080866 49.47 µM -0.569592224783882 0.275719443128448 no 2450 0.284477151604938 3425 17066299
SGTC_2664 lyso-paf C-16 73.48 µM -0.571031779402036 0.275232296876974 no 2451 0.283989050498143 3437 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1162 k048-0130 20.1 µM -0.571435914027255 0.275095613660158 no 2452 0.283852095079489 3402 6797406
SGTC_2619 obliquin 87.91 µM -0.57172469353816 0.274997965420848 no 2453 0.283754251223526 3469 6708593 A bioactive alkalod. YER133W GLC7
SGTC_88 0180-0332 8.668 µM -0.571897830026513 0.274939429036645 no 2454 0.283695597114084 3459 3101745
SGTC_349 k015-0014 24 µM -0.572055272037312 0.274886204189614 no 2455 0.283642264924358 3394 2196908
SGTC_945 3381-0768 11.3 µM -0.573491680951413 0.274400846416021 no 2456 0.283155915109063 3501 1126236 YIL048W NEO1
SGTC_166 k072-0058 166.424 µM -0.573732606410273 0.274319479951352 no 2457 0.283074380008785 3505 5846229
SGTC_252 miconazole 1.30953 nM -0.574016061022341 0.274223765597676 no 2458 0.282978466426557 3434 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2255 7941087 197.44 µM -0.574374773184834 0.274102662612301 no 2459 0.282857110039299 3519 935561
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.577045935944598 0.273201696798247 no 2460 0.281954212383504 3462 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1291 0993-0025 5.79 µM -0.578466549018158 0.272723131653319 no 2461 0.281474587611945 3525 4353356
SGTC_1192 1488-0095 21.4 µM -0.578660449525886 0.272657844226451 no 2462 0.281409153822373 3466 915875
SGTC_163 TUB2.036 7.546 µM -0.579509064189987 0.272372202034548 no 2463 0.281122866170254 3464 15992207 YJR013W GPI14
SGTC_729 4092-0585 94.1 µM -0.580773304371755 0.271946936896169 no 2464 0.280696624664888 3412 2169061
SGTC_2700 st077718 96.8 µM -0.581047938943687 0.271854598997277 no 2465 0.280604072329343 3444 904970
SGTC_347 4534-1311 26.2 µM -0.582435125598747 0.271388436294104 no 2466 0.280136813756089 3489 2862016
SGTC_2005 4024620 188 µM -0.584303295610222 0.270761269641416 no 2467 0.279508137655822 3500 236743
SGTC_726 3448-4391 34.2 µM -0.586209440780169 0.27012210093927 no 2468 0.278867389104052 3589 1356692
SGTC_3011 9081274 71.4286 µM -0.587708420677258 0.269619993618185 no 2469 0.27836401124477 3440 6625322
SGTC_579 4491-1009 110 µM -0.588844917224861 0.269239617807069 no 2470 0.277982655627855 3607 1271041
SGTC_1917 st066507 28.5 µM -0.590569728081213 0.268662852854968 no 2471 0.277404376485287 3408 3156428
SGTC_2804 7954240 19.48 µM -0.591299058959894 0.268419156494386 no 2472 0.277160030001656 3509 828705
SGTC_447 ml7 120 µM -0.592396275666767 0.268052745421467 no 2473 0.276792629848618 3526 4216 Selective myosin light chain kinase inhibitor.
SGTC_2991 9074669 71.4286 µM -0.593610252181201 0.267647636507996 no 2474 0.276386411175926 3523 17333109
SGTC_2304 7443016 91.4 µM -0.59409309773728 0.267486594798711 no 2475 0.276224923569805 3480 939854
SGTC_580 1123-0028 41 µM -0.594359657770957 0.267397710946062 no 2476 0.27613579245763 3558 1677248 YPR107C YTH1
SGTC_213 1246-0773 967 nM -0.595371674733666 0.267060391841395 no 2477 0.275797527505633 3465 6251622
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.595658840110844 0.266964714840217 no 2478 0.275701580066685 3421 6708630 An antioxidant.
SGTC_1189 1431-2119 7.28 µM -0.596043437317465 0.266836602885816 no 2479 0.275573104500078 3551 3107275
SGTC_141 0443-0274 32.331 µM -0.597356570031734 0.266399423639615 no 2480 0.275134671538162 3614 1627241
SGTC_2056 5235370 200 µM -0.598568261694955 0.265996338737997 no 2481 0.2747304129944 3452 5511916
SGTC_1708 st033234 31.827 µM -0.604067878635491 0.264170711900222 no 2482 0.272899257117613 3570 674664
SGTC_697 0508-1955 564 µM -0.606273381734017 0.263440380593624 no 2483 0.27216661560246 3536 6243113
SGTC_2967 9089538 49.85 µM -0.608012260628773 0.262865294967621 no 2484 0.271589671113378 3555 728216
SGTC_3208 9114115 49.47 µM -0.608029162986462 0.262859708136788 no 2485 0.271584066052072 3471 650895
SGTC_1683 st010134 710 nM -0.608112333125833 0.262832218329875 no 2486 0.271556486494491 3517 3818134
SGTC_195 4234-0266 16.654 µM -0.608787239560833 0.262609199291806 no 2487 0.271332736361833 3481 2303354
SGTC_2982 9019404 25.97 µM -0.609039005684616 0.262526029398338 no 2488 0.271249292470489 3427 22333232
SGTC_838 0109-0203 71.4 µM -0.611768771891725 0.261625128869036 no 2489 0.270345376806167 3545 759422
SGTC_2716 st080858 38.6235 µM -0.612012368644185 0.261544812190486 no 2490 0.270264787123511 3534 5296050
SGTC_1804 st050076 49.1 µM -0.613722270306205 0.260981394218378 no 2491 0.269699434665952 3548 3895976
SGTC_3312 9133330 71.43 µM -0.616204984504926 0.260164444446905 no 2492 0.268879619546095 3576 17617324
SGTC_1565 sinapyl alcohol 95.1 µM -0.616817148019628 0.259963211684127 no 2493 0.268677669991312 3530 5280507 A phenol propionate derived from cinnamic acid.
SGTC_144 4161-2749 112.381 µM -0.616871132265118 0.259945469626233 no 2494 0.268659864527358 3484 797501 YMR168C CEP3
SGTC_198 3454-2873 16.191 µM -0.6175983966771 0.259706513243707 no 2495 0.268420050870935 3487 710957
SGTC_2914 7968218 45.32 µM -0.618231487773233 0.259498591614242 no 2496 0.268211378307336 3513 2977111
SGTC_288 1315-0019 35.1 µM -0.619864351398801 0.258962718845059 no 2497 0.267673548690435 3573 6811474
SGTC_1846 st056244 14.8 µM -0.619987478589769 0.258922334215168 no 2498 0.267633015332397 3494 5393182
SGTC_3071 9117417 49.47 µM -0.621225121208029 0.258516579417083 no 2499 0.267225756443981 3465 45595590 YGL055W OLE1
SGTC_2316 5844804 197.44 µM -0.622580545615879 0.258072588585434 no 2500 0.26678009937477 3574 776813
SGTC_839 0122-0028 230 µM -0.623502697289512 0.257770749325536 no 2501 0.2664771151535 3527 759448
SGTC_2146 5545642 200 µM -0.62557051174215 0.257094577740721 no 2502 0.265798342747461 3566 825326
SGTC_1721 st082152 9.2685 µM -0.626072390356822 0.2569306035627 no 2503 0.265633730366625 3541 5296051
SGTC_505 gw-5074 63.9 µM -0.626595795178505 0.256759654309012 no 2504 0.265462112643341 3552 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1324 1418-0026 34.4 µM -0.6273429269203 0.256515736225038 no 2505 0.265217235239313 3587 1372513
SGTC_1923 st058458 19.1 µM -0.62752745502184 0.25645551143909 no 2506 0.265156772592261 3622 3534982
SGTC_2046 4110841 106 µM -0.628115689808829 0.256263577322572 no 2507 0.264964077778703 3581 44119630 YMR134W ERG29
SGTC_2863 9028737 58.44 µM -0.62815003723919 0.256252372472968 no 2508 0.264952828396319 3512 6460917
SGTC_1915 st067105 30.6 µM -0.628259524866012 0.256216657025691 no 2509 0.264916970909276 3572 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2407 paclitaxel 400 µM -0.629490318822579 0.255815344122832 no 2510 0.264514052401217 3592 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1449 4112-4002 201 µM -0.630126201527059 0.255608136710818 no 2511 0.264306009075703 3547 2059539
SGTC_259 usnic acid 108.925 µM -0.63028607222624 0.255556055371355 no 2512 0.264253716890517 3633 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_919 tnp00227 403.569 nM -0.631457276659943 0.255174679307744 no 2513 0.263870787801301 3567 1269246 A methoxyflavone. YNL221C POP1
SGTC_2124 5246320 200 µM -0.631906486495531 0.255028483357445 no 2514 0.263723992283885 3557 579342
SGTC_1988 st071872 53.4 µM -0.632192185841036 0.254935524920051 no 2515 0.263630651391463 3583 16414116
SGTC_1815 st051655 58.2 µM -0.632732371633046 0.254759812302503 no 2516 0.263454213251675 3542 5984156
SGTC_3050 9093513 49.47 µM -0.63321181761783 0.254603910370037 no 2517 0.263297664752054 3584 25236664
SGTC_1273 0849-0096 14.1 µM -0.634440625114295 0.254204566086034 no 2518 0.262896652070062 3562 5286025
SGTC_1477 0139-0234 16 µM -0.635622394466959 0.253820818569957 no 2519 0.262511284745705 3574 620880
SGTC_3199 9111318 49.47 µM -0.635716699420391 0.253790208704004 no 2520 0.262480544974449 3529 8548020
SGTC_1682 st012968 530 nM -0.636104103383837 0.253664483965679 no 2521 0.262354285586476 3486 24207270
SGTC_2752 diclazuril 33.15 µM -0.637211856091445 0.253305164033991 no 2522 0.261993427994254 3611 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_121 0557-0495 61.343 µM -0.64066868460837 0.252185600915732 no 2523 0.260868982081042 3685 3104427
SGTC_108 0509-0257 621.132 µM -0.640699826335639 0.252175526918197 no 2524 0.260858863515167 3562 536624
SGTC_1970 st070122 35.8 µM -0.640731727203338 0.252165207567364 no 2525 0.260848498498815 3627 102928
SGTC_2881 9058953 51.95 µM -0.642227309524094 0.25168166396298 no 2526 0.260362801802267 3551 17122249
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.643450100293359 0.251286682022213 no 2527 0.25996604175972 3612 1273210
SGTC_3306 9127676 59.7925 µM -0.645078825150898 0.250761085997967 no 2528 0.259438052604131 3558 41905287
SGTC_928 2764-0428 58.7 µM -0.646178593090515 0.250406515995625 no 2529 0.25908185070769 3579 662578
SGTC_1964 st076914 61 µM -0.646921281695478 0.250167220340472 no 2530 0.258841445733323 3603 24208661
SGTC_1269 0831-0796 3.05 µM -0.650131908970408 0.249134147282162 no 2531 0.257803509680908 3604 927758
SGTC_2059 5238311 157 µM -0.650499860914026 0.24901589768739 no 2532 0.257684695777744 3594 703021
SGTC_150 3970-0969 77.2 µM -0.651678497518169 0.248637317559836 no 2533 0.257304298374969 3608 6615640
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.652309697539345 0.248434701136239 no 2534 0.257100702686346 3646 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1691 st019933 84.6 µM -0.652594285796491 0.248343376546822 no 2535 0.257008935197028 3581 6176082
SGTC_2246 7293507 91.5585 µM -0.652905736252274 0.248243452370436 no 2536 0.256908525332857 3603 887656
SGTC_3238 9133470 49.47 µM -0.653693795322276 0.247990711298732 no 2537 0.256654550746334 3616 3534688
SGTC_1064 honokiol 6.76 µM -0.653889230097371 0.247928054010047 no 2538 0.256591586535223 3596 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_684 1140-0066 328 µM -0.654260878153551 0.247808925245992 no 2539 0.256471872998346 3608 6813534
SGTC_1461 k072-0203 53.8 µM -0.65560117988404 0.247379556369236 no 2540 0.256040383083788 3548 5418714
SGTC_1626 st003712 1.76 µM -0.655895791669687 0.247285230113789 no 2541 0.255945588058193 3579 24207035
SGTC_1076 itraconazole 331 nM -0.656644405680486 0.247045631885244 no 2542 0.255704794552444 3626 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2431 5490079 200 µM -0.656793931650379 0.246997790122104 no 2543 0.255656713339265 3616 5722345
SGTC_1120 ficusin 1.78878 µM -0.658778057301569 0.246363426380083 no 2544 0.255019149900056 3639 6199 A DNA cross-linker.
SGTC_2525 harmine 47.85 µM -0.659213585499401 0.246224296477821 no 2545 0.254879312089027 3569 5280953 A monoamine oxidase inhibitor
SGTC_2878 9043973 25.97 µM -0.659795697454866 0.246038406057776 no 2546 0.254692472382423 3644 6465167
SGTC_1478 0453-0656 35.7 µM -0.661174162861946 0.245598510188989 no 2547 0.254250314337345 3628 5258496
SGTC_520 3584-0023 682 µM -0.661660623812534 0.245443371679403 no 2548 0.254094372732455 3568 1340790
SGTC_168 3970-0862 530.542 µM -0.661672000481285 0.245439744147042 no 2549 0.254090726388644 3627 3135186
SGTC_1421 4029-0249 71.4 µM -0.66170151292953 0.245430334025725 no 2550 0.254081267461815 3689 2894095
SGTC_2099 5377090 177.372 µM -0.664055502790299 0.244680383027109 no 2551 0.253327394129328 3596 2243829
SGTC_2780 5215298 71.43 µM -0.664700865196262 0.244474994564315 no 2552 0.253120920169869 3620 2834131
SGTC_2523 spermine 47.74 µM -0.665036861324018 0.244368099599013 no 2553 0.253013458331044 3595 1103 A DNA binding polyamine.
SGTC_2909 7941780 10.49 µM -0.665334495186261 0.244273430379843 no 2554 0.252918285972105 3624 1243215
SGTC_1096 rimcazole 32.2 µM -0.665347460205414 0.244269307010028 no 2555 0.25291414066426 3564 18528119 A dopamine reuptake inhibitor.
SGTC_1232 0279-0259 161 µM -0.665711512327203 0.244153539891649 no 2556 0.252797756816085 3645 1560000
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.665912920709753 0.244089505545523 no 2557 0.25273338067317 3555 641818 YHR062C RPP1
SGTC_1875 nocodazole 6 µM -0.666214798892363 0.243993545511403 no 2558 0.252636907545563 3623 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.667124812256012 0.243704396670673 no 2559 0.252346206205444 3601 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1295 1013-0063 9.78 µM -0.667343983273937 0.243634784637312 no 2560 0.252276218966563 3626 6826038
SGTC_1082 camptothecin 424.86 nM -0.668175962866932 0.243370633090786 no 2561 0.252010638552442 3567 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3283 9109332 35.8195 µM -0.668502213427024 0.243267091570639 no 2562 0.251906534742756 3523 17027281
SGTC_1978 st071761 42 µM -0.669442558378498 0.24296878934736 no 2563 0.251606605617532 3576 5147680
SGTC_210 3551-0445 56.827 µM -0.670063949601373 0.242771776296283 no 2564 0.251408512419039 3667 2865180 YOR207C RET1
SGTC_2138 5575593 77.673 µM -0.670217060652265 0.242723245480651 no 2565 0.251359714835261 3624 762213
SGTC_1547 harmine 94.2 µM -0.670578592057285 0.242608673589466 no 2566 0.25124451206988 3666 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1260 0700-1617 7.75 µM -0.672877715358873 0.241880750697 no 2567 0.250512545278683 3630 2853078
SGTC_45 0kpi-0036 14.9 µM -0.674212995601128 0.241458533653027 no 2568 0.250087954334417 3622 2795021
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.676991982925168 0.240581099879428 no 2569 0.249205520510854 3665 4213774
SGTC_1062 mesoridazine 14.2 µM -0.678520825929016 0.240099126223964 no 2570 0.248720761896852 3640 4078 A neuroleptic.
SGTC_383 2324-0395 7.37 µM -0.6787636208868 0.240022632639771 no 2571 0.248643823802904 3647 3146421
SGTC_1735 st034310 56.75 µM -0.679228581244797 0.239876181997312 no 2572 0.248496520203412 3690 871153
SGTC_501 nsc-95397 161 µM -0.679783158646115 0.239701568030758 no 2573 0.248320885949346 3658 262093
SGTC_2034 5197015 53.07 µM -0.67995001497402 0.239649045307379 no 2574 0.248268055627227 3650 780676
SGTC_3103 9120822 49.47 µM -0.680491623986646 0.239478601926648 no 2575 0.248096611805849 3708 17141819
SGTC_966 1300-0360 30.2 µM -0.680975287963489 0.239326449709838 no 2576 0.247943563614887 3638 70588
SGTC_3187 9109394 49.47 µM -0.682266783591577 0.238920426687824 no 2577 0.24753513627058 3597 17098090
SGTC_3206 9114350 49.47 µM -0.682384879305006 0.238883318323359 no 2578 0.247497807191505 3593 17087243
SGTC_1780 st038448 24.544 µM -0.682877685024288 0.238728501561901 no 2579 0.24734206784633 3680 728868 YDL195W SEC31
SGTC_395 anisomycin 6.25 µM -0.68290961157247 0.238718473611024 no 2580 0.247331980039052 3607 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2153 5569715 200 µM -0.682928354720246 0.238712586600121 no 2581 0.24732605788329 3663 2054701
SGTC_648 0375-0473 33.3 µM -0.683546052311452 0.238518619219076 no 2582 0.247130930240416 3655 1713139
SGTC_533 1222-0222 6.71 µM -0.684690709157675 0.238159406008201 no 2583 0.246769556530004 3718 3982874
SGTC_1494 4358-1428 177 µM -0.685116398871416 0.238025892835131 no 2584 0.24663523643326 3679 1564571
SGTC_2243 6634756 200 µM -0.687404282802004 0.237309024996085 no 2585 0.245913999756457 3697 885676
SGTC_2289 7946404 165.07 µM -0.687689781197327 0.237219652423064 no 2586 0.245824078225399 3701 1246120 YPR165W RHO1
SGTC_2141 5621638 7.665 µM -0.688409169254089 0.236994536803838 no 2587 0.24559757564333 3666 2856238
SGTC_2283 7944793 200 µM -0.689145216652313 0.236764329612929 no 2588 0.245365943862183 3650 2970533
SGTC_3234 9132280 49.47 µM -0.689394091282805 0.236686519072951 no 2589 0.245287650375519 3668 17612295
SGTC_58 0957-0393 9 µM -0.689657401764235 0.236604210486814 no 2590 0.245204830136728 3614 6997992
SGTC_1991 st073000 8.92 µM -0.691016169863311 0.236179721706804 no 2591 0.244777689744615 3713 4301969 YIL048W NEO1
SGTC_1445 4239-0156 97.7 µM -0.693943616661165 0.235266593673761 no 2592 0.243858784507584 3717 4008346
SGTC_2151 5563267 85.4165 µM -0.697753899487242 0.23408101694102 no 2593 0.242665557000413 3692 5310824
SGTC_2951 9072950 58.06 µM -0.699046213524473 0.233679663664306 no 2594 0.242261575199636 3691 16488155
SGTC_995 3931-2021 34.6 µM -0.699840755433182 0.233433092719507 no 2595 0.24201337973676 3680 730143
SGTC_3065 9113888 49.47 µM -0.700390664232309 0.233262523548634 no 2596 0.241841682461 3722 16648368
SGTC_1335 1486-0900 202 µM -0.701314567842392 0.232976105510731 no 2597 0.241553362164698 3696 X1335
SGTC_1052 3253-3998 198 µM -0.702870985760332 0.232494044600465 no 2598 0.241068077073343 3667 5450317
SGTC_2006 4011487 200 µM -0.705478135176622 0.231687790475802 no 2599 0.240256367064833 3725 45595294
SGTC_2946 9065502 71.43 µM -0.708198169427028 0.230848290276172 no 2600 0.239411101397599 3521 16489101
SGTC_2235 salicylic acid 500 µM -0.708555148051785 0.230738240095899 no 2601 0.23930028900394 3689 338 A COX inhibitor and kinase inhibitor.
SGTC_3064 1327-0027 10 µM -0.708559352725334 0.230736944044243 no 2602 0.239298983966885 3578 16000455 YPR107C YTH1
SGTC_1368 1852-0141 284 µM -0.708590411393148 0.230727370623678 no 2603 0.239289344168335 3663 2838987
SGTC_3039 9090270 49.47 µM -0.709465576398105 0.230457703900806 no 2604 0.239017803057636 3664 17173750
SGTC_2313 7726885 200 µM -0.709940325384345 0.23031149208131 no 2605 0.238870571210279 3677 726423
SGTC_1668 st014914 51.6 µM -0.710533660582807 0.230128831372476 no 2606 0.238686632489203 3696 2839556
SGTC_3114 9122766 49.47 µM -0.711073002144587 0.229962863173861 no 2607 0.23851949949994 3669 17176985
SGTC_978 1416-0512 87.4 µM -0.711476914655515 0.229838613593227 no 2608 0.238394375689876 3742 6814003
SGTC_1139 k015-0024 46.9 µM -0.713841991896129 0.229111835015822 no 2609 0.237662445189802 3673 2766652
SGTC_253 dyclonine 31.25 µM -0.715821112061549 0.228504651449984 no 2610 0.237050907262149 3776 3180 An oral anasthetic.
SGTC_128 0906-2981 13.371 µM -0.716710355415459 0.228232130911767 no 2611 0.236776417466189 3662 6740226
SGTC_2886 9058944 51.95 µM -0.717151308443617 0.228097062742136 no 2612 0.236640369854335 3573 4949929
SGTC_3309 9129340 25.759 µM -0.718058743364501 0.227819248147669 no 2613 0.236360533547268 3743 17158987
SGTC_1614 st002383 48.6 µM -0.719720342655478 0.227311037202041 no 2614 0.235848599312262 3695 1947235
SGTC_531 3788-1495 174 µM -0.720166161370794 0.227174789418763 no 2615 0.235711347851799 3676 2896655
SGTC_2248 tofa 1.1 µM -0.721137288407043 0.22687816023461 no 2616 0.235412525491633 3646 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2212 7123476 200 µM -0.72157752197598 0.226743763604206 no 2617 0.235277131547399 3666 1085715
SGTC_2919 7978188 46.38 µM -0.724950374139503 0.225715574789028 no 2618 0.234241237780255 3685 2980291
SGTC_652 0437-0092 114 µM -0.726355215664227 0.225288098662389 no 2619 0.23381051907539 3697 3091274
SGTC_1091 telmisartan 47.6 µM -0.728231361240694 0.224717926126484 no 2620 0.233235985602517 3776 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2588 indole-3-carbinol 100 µM -0.729113462322455 0.224450133111609 no 2621 0.232966130174352 3725 3712 Induces cell cycle arrest.
SGTC_828 2074-0507 139 µM -0.731311746848034 0.223783554658554 no 2622 0.232294378511475 3764 X828
SGTC_2370 9071495 200 µM -0.731787438651164 0.223639460467803 no 2623 0.232149158599006 3691 21791103
SGTC_2266 7929956 200 µM -0.732254447929101 0.22349804768273 no 2624 0.2320066384685 3712 2967153
SGTC_3014 9081533 49.47 µM -0.732278321377505 0.223490820047938 no 2625 0.231999354168598 3727 21367265
SGTC_852 0418-0143 439 µM -0.732998916928452 0.223272723889041 no 2626 0.231779544988269 3755 5369229
SGTC_2781 5567276 71.43 µM -0.734363879700146 0.222859935139274 no 2627 0.231363497392094 3763 2853274
SGTC_746 1095-0025 46.6 µM -0.735631675222013 0.222476921257169 no 2628 0.230977440236032 3728 6749286
SGTC_3295 9122362 53.5725 µM -0.737097586872956 0.222034522812112 no 2629 0.230531503271847 3752 4730473
SGTC_2678 equilin 100 µM -0.7372055761015 0.222001952545072 no 2630 0.23049867149916 3740 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2800 7887935 81.82 µM -0.740698910606955 0.220949812089857 no 2631 0.229438010017547 3730 2961002
SGTC_3351 9150312 21.596 µM -0.7412409314719 0.220786819636002 no 2632 0.229273684759213 3710 4904905
SGTC_3085 9117376 49.47 µM -0.742234790185005 0.220488132834257 no 2633 0.228972546654849 3826 16480349
SGTC_925 2064-1272 59.6 µM -0.742487751166978 0.220412146834262 no 2634 0.228895935201057 3748 6815817
SGTC_3323 9138564 53.9225 µM -0.743369401354745 0.220147428593462 no 2635 0.228629032178134 3737 43912313 YNL103W MET4
SGTC_2079 5212404 121 µM -0.744092599596619 0.219930422246924 no 2636 0.228410228050649 3711 758462
SGTC_3281 9140613 49.47 µM -0.744898729399095 0.219688675792247 no 2637 0.228166471658851 3702 16013766
SGTC_2598 perillyl alcohol 100 µM -0.744968652865858 0.219667713968003 no 2638 0.228145335195359 3757 10819 An apoptosis inducer.
SGTC_2751 anetholtrithion 17.25 µM -0.745100571828709 0.21962817011297 no 2639 0.228105461733115 3755 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2608 thymoquinone 42.66 µM -0.745139165099873 0.219616602217651 no 2640 0.228093797378275 3698 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_20 0481-0013 4.944 µM -0.746065097063597 0.219339169534128 no 2641 0.227814046093254 3748 182045
SGTC_1068 loratadine 26.9 µM -0.746705253140086 0.219147480362351 no 2642 0.22762074905568 3785 3957 A H1 histamine antagonist.
SGTC_2744 captopril 92.04 µM -0.747644030495374 0.218866545908733 no 2643 0.227337449505043 3700 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2309 7664088 163.95 µM -0.747999848663902 0.218760119475388 no 2644 0.227230124412582 3737 704922
SGTC_2524 avocatin b 10.57 µM -0.748516093702902 0.218605761777739 no 2645 0.227074460698614 3721 6710748
SGTC_2831 7999036 19.48 µM -0.748537125456708 0.218599474595339 no 2646 0.227068120254561 3796 2988270
SGTC_850 0388-0143 75.9 µM -0.748921292044468 0.21848465106877 no 2647 0.226952323095593 3721 67273
SGTC_1949 st076024 69.1 µM -0.749839924227205 0.218210222024583 no 2648 0.226675560077606 3729 2921930
SGTC_2499 avocadenofuran 51.48 µM -0.751461382517684 0.217726318138883 no 2649 0.226187516636824 3752 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2917 7979103 53.79 µM -0.75346139709056 0.217130292509196 no 2650 0.225586350056004 3799 2980565
SGTC_2929 9013348 24.6 µM -0.755242598640277 0.216600269984944 no 2651 0.225051716599012 3794 2995952
SGTC_2520 obtusaquinone 4.71 µM -0.756424863190622 0.216248883548096 no 2652 0.224697252837609 3793 5967872
SGTC_1702 st027038 51 µM -0.757223337340422 0.216011752109387 no 2653 0.224458035454869 3774 5521182
SGTC_205 1486-1330 71.903 µM -0.758267459549881 0.215701895322521 no 2654 0.224145441767608 3749 4118834
SGTC_1213 1315-0166 115 µM -0.75861944186216 0.215597498115139 no 2655 0.224040119574702 3823 768401
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.760657465007471 0.214993601011593 no 2656 0.223430843387528 3772 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1687 st020778 55.3625 µM -0.761219611390573 0.214827201533332 no 2657 0.223262953217476 3779 4259299
SGTC_2346 9031566 143.75 µM -0.761952132973462 0.214610482047732 no 2658 0.223044286716575 3756 4771086
SGTC_2894 9048625 32.47 µM -0.762532373453382 0.214438905777146 no 2659 0.222871164556521 3799 4092861
SGTC_3338 9144300 39.5675 µM -0.763579197989907 0.214129563117264 no 2660 0.222559024810452 3806 4901274
SGTC_1727 st034309 9.9045 µM -0.764455284120449 0.213870874351293 no 2661 0.222297987150007 3861 870305
SGTC_589 1227-0070 34.1 µM -0.76498076464683 0.213715798975136 no 2662 0.222141499394723 3803 2841384
SGTC_311 1315-0136 58 µM -0.766793681695533 0.21318128922733 no 2663 0.221602096786036 3824 6759207
SGTC_1966 st070145 16.1 µM -0.767224500510599 0.213054383902886 no 2664 0.221474024145167 3747 3748532
SGTC_2413 inermin 26.06 µM -0.767954672444117 0.212839399485594 no 2665 0.221257057289544 3835 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1020 4335-0961 93.3 µM -0.768564743776764 0.212659873403895 no 2666 0.22107587097572 3734 669075
SGTC_330 1488-0319 80.1 µM -0.769155209506437 0.212486200912436 no 2667 0.220900588253326 3823 6846614
SGTC_2476 5806916 10.51 µM -0.769368781143073 0.212423403928852 no 2668 0.220837208036945 3710 2870194
SGTC_399 oxolinic acid 75 µM -0.773789908117677 0.211125886707229 no 2669 0.219527520706189 3761 4628 A DNA gyrase inhibitor.
SGTC_1524 corynanthine 62.1 µM -0.774049255272114 0.211049917718238 no 2670 0.219450832093249 3900 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_862 0452-0056 10.2 µM -0.775400057610452 0.210654494530253 no 2671 0.219051650549874 3738 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_3073 9114972 49.47 µM -0.775552598701346 0.21060986818894 no 2672 0.219006598715273 3726 41905075
SGTC_968 1309-0633 340 µM -0.775745723826362 0.210553376828109 no 2673 0.218949568344275 3802 3761976
SGTC_1224 0823-0416 294 µM -0.777360446018681 0.21008139977247 no 2674 0.218473070937646 3864 3598164
SGTC_637 1181-0519 7.26 µM -0.777948445651845 0.209909684252881 no 2675 0.218299703273345 3811 6252091 YGR060W ERG25
SGTC_3293 9120939 62.045 µM -0.778252416962896 0.209820946838472 no 2676 0.218210110501076 3773 934087
SGTC_1447 4239-0816 81.9 µM -0.778425559058735 0.209770411855674 no 2677 0.218159087920212 3808 1341554
SGTC_2980 9014342 25.29 µM -0.779532058764063 0.209447626819903 no 2678 0.21783318017618 3867 2996599
SGTC_3025 9087895 49.47 µM -0.780556901683759 0.209148923317296 no 2679 0.217531574219909 3818 17173641
SGTC_1172 0370-0043 85 µM -0.781521497556532 0.2088680088468 no 2680 0.217247918977678 3847 376585
SGTC_2954 9074818 52.69 µM -0.784236799228406 0.20807843956759 no 2681 0.216450588052124 3801 16648742
SGTC_677 0929-0063 136 µM -0.784416093118544 0.208026365654001 no 2682 0.216397999219849 3775 1539583
SGTC_2014 4013930 200 µM -0.786910083354094 0.207302812070537 no 2683 0.215667252193587 3774 64556
SGTC_2483 5729050 27.16 µM -0.787156219246426 0.207231484176657 no 2684 0.21559521124653 3810 2865180
SGTC_1383 3049-0032 20.7 µM -0.787835415876373 0.207034734606351 no 2685 0.215396491146654 3859 712864
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.79099386146317 0.206121249660937 no 2686 0.214473786807783 3877 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.791528411707227 0.205966883950849 no 2687 0.214317851676255 3885 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1583 clindamycin 39.6 µM -0.792129852434785 0.205793283823048 no 2688 0.214142482599435 3787 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1138 3761-0006 1.03 µM -0.792307666977582 0.205741975985177 no 2689 0.21409065113961 3783 12061087
SGTC_161 4065-0411 162.148 µM -0.793095740023751 0.20551467133266 no 2690 0.213861022304376 3878 1906281 YLR208W SEC13
SGTC_2621 lithochol-11-enic acid 100 µM -0.7933364431235 0.205445274847486 no 2691 0.213790914802528 3772 6708711
SGTC_934 2950-0684 338 µM -0.795466821601877 0.204831677814234 no 2692 0.213171001674228 3878 1121253
SGTC_3297 9117502 71.43 µM -0.796733743605733 0.204467293045941 no 2693 0.21280284108342 3835 7453720
SGTC_2859 9028643 45.46 µM -0.799554281932824 0.203657452982865 no 2694 0.211984542361413 3752 17151580
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.799785458019932 0.203591162034638 no 2695 0.211917554916163 3884 688664
SGTC_1850 st056238 17 µM -0.800678659449402 0.203335152805699 no 2696 0.211658850049429 3839 5393177
SGTC_251 melphalan 456.522 µM -0.801673548904752 0.203050224037207 no 2697 0.211370910227142 3883 460612 A DNA alkylator.
SGTC_2851 9015922 71.43 µM -0.802089506835406 0.202931167560219 no 2698 0.211250592183702 3824 2996893
SGTC_636 0kpi-0074 126 µM -0.804005351817756 0.202383348301962 no 2699 0.210696942097438 3862 616434
SGTC_3180 9109287 49.47 µM -0.808631591354723 0.201064166495476 no 2700 0.209363543847056 3888 18891271
SGTC_711 k292-0785 179 µM -0.808888150228773 0.200991159457522 no 2701 0.209289742766861 3823 4146315
SGTC_632 0781-2353 4.65 µM -0.808907481526525 0.200985659139194 no 2702 0.209284182594788 3900 6811515 YHR007C ERG11
SGTC_797 k781-0471 270 µM -0.809409086645385 0.200842969417524 no 2703 0.209139938626077 3823 23738129
SGTC_2303 7774051 200 µM -0.809609035151359 0.200786107768252 no 2704 0.209082456797699 3803 2953184
SGTC_301 4119-0100 24.5 µM -0.809662838004474 0.200770808883872 no 2705 0.209066990972103 3867 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2985 9022375 71.43 µM -0.810973676658431 0.200398287077027 no 2706 0.208690393837219 3863 4939335
SGTC_3026 9090633 49.47 µM -0.811107862742406 0.200360176730734 no 2707 0.208651865445202 3861 25236842
SGTC_3327 9140648 26.9345 µM -0.811838045128658 0.200152873098757 no 2708 0.208442284166594 3868 8029710
SGTC_3118 9124250 49.47 µM -0.813777193957726 0.199602961986301 no 2709 0.207886301172117 3806 1504786
SGTC_622 1348-1566 26.3 µM -0.814031842056844 0.199530815519384 no 2710 0.207813354856195 3902 7340407
SGTC_1615 st002656 86.5 µM -0.814189447480793 0.199486170882507 no 2711 0.207768214891546 3843 1584458
SGTC_751 0833-0568 350 µM -0.814868551167498 0.199293871048138 no 2712 0.207573778215723 3927 6954252
SGTC_3093 9117344 49.47 µM -0.816361021663306 0.198871644912452 no 2713 0.207146841509787 3903 24824913
SGTC_2318 6029776 164 µM -0.818938218211289 0.19814381590409 no 2714 0.206410831732944 3830 818325
SGTC_742 0kpi-0133 140 µM -0.822570807576572 0.197120667418929 no 2715 0.205376052585446 3928 2728852
SGTC_1767 st044992 70.3 µM -0.822605793660383 0.197110828871882 no 2716 0.205366101455693 3920 9600693
SGTC_1791 st048313 56.1 µM -0.823019586683544 0.196994487372652 no 2717 0.205248427582967 3812 1204976
SGTC_21 0849-0113 22.993 µM -0.823324026028624 0.19690891815457 no 2718 0.205161877137691 3813 1560156
SGTC_1012 4112-3522 18 µM -0.825546369384388 0.19628496274913 no 2719 0.204530734310745 3842 3112398
SGTC_2989 9073649 71.4286 µM -0.826749123812264 0.195947772331244 no 2720 0.204189635923918 3790 21367202
SGTC_343 4130-2827 29.8 µM -0.82699667833507 0.195878414423764 no 2721 0.204119472095002 3925 1118244
SGTC_153 4077-0274 519.67 µM -0.828154869311142 0.195554119383776 no 2722 0.203791399410838 3890 3121976
SGTC_2685 mycophenolic acid 18.85 µM -0.828182736992351 0.195546320414164 no 2723 0.203783509401477 3848 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.828827476775443 0.195365938118931 no 2724 0.203601018940393 3885 689007
SGTC_3047 9092122 49.47 µM -0.82892105546187 0.19533976551257 no 2725 0.203574540049629 3857 17173831
SGTC_3246 9135460 32.98 µM -0.829261677099685 0.195244516552082 no 2726 0.203478175584641 3779 41446951
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.829320437844528 0.195228087978911 no 2727 0.203461554473132 3949 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2518 prenyletin 46.28 µM -0.831644627620729 0.194578955234175 no 2728 0.202804782061988 3825 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2986 9022445 71.43 µM -0.83166869678343 0.194572239735268 no 2729 0.202797987201403 3856 6459286
SGTC_299 1273-0059 1.44 µM -0.835085353122253 0.193620395441841 no 2730 0.201834826418347 3796 2848077
SGTC_1646 st011709 75.6 µM -0.835493138827999 0.19350698064953 no 2731 0.201720054228262 3823 5757843
SGTC_1684 st024538 14.6195 µM -0.836636257472849 0.193189268560255 no 2732 0.201398529382856 3865 6732859
SGTC_2768 sulfasalazine 50.2 µM -0.836984151984203 0.193092639913382 no 2733 0.2013007381322 3858 5384001 An antioxidant and salicylic acid derivative.
SGTC_563 tetrahydrosecaminediol 614 µM -0.837172176935066 0.193040427757769 no 2734 0.201247897195266 3941 334274 A psychoactive constituent of the cannabis plant.
SGTC_2259 7964009 200 µM -0.8376149965425 0.19291749640515 no 2735 0.201123483789833 3934 313134
SGTC_476 mead acid 10 µM -0.838115085651641 0.192778723944334 no 2736 0.200983035573899 3895 5312531 An omega 9 fatty acid.
SGTC_2019 4016004 108 µM -0.838834098008251 0.192579308187235 no 2737 0.200781206699236 3919 45595336
SGTC_1579 chlormadinone acetate 49.4 µM -0.839385808299809 0.192426378642011 no 2738 0.200626422515967 3930 45114258 A steroidal progestin.
SGTC_1678 st019265 80.2 µM -0.839972875909084 0.192263729909684 no 2739 0.200461797418089 3866 5367020
SGTC_799 1310-0557 151 µM -0.843151970902789 0.191384414145514 no 2740 0.199571727935701 3986 5354492
SGTC_271 rotenone 740 µM -0.844523460498786 0.191005831738899 no 2741 0.199188479619794 3898 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1808 st050063 61.5 µM -0.8447435000182 0.190945135389856 no 2742 0.199127033187715 3860 4011993
SGTC_274 sirtinol 40.1 µM -0.845010022910884 0.190871632776468 no 2743 0.199052621484102 3952 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2827 7993847 71.43 µM -0.84651929487548 0.190455728047985 no 2744 0.198631557340765 3963 2985692
SGTC_2947 9072639 7.68 µM -0.848201921055716 0.189992709315571 no 2745 0.198162763786865 3944 16488146
SGTC_2642 cholecalciferol 100 µM -0.848744098363117 0.189843662524509 no 2746 0.198011851117243 3874 9821465 A vitamin D precursor, similar to steriods.
SGTC_1287 0971-0001 34.6 µM -0.849247171164128 0.189705430047478 no 2747 0.197871885113436 3888 4665869
SGTC_1422 4031-0024 15.5 µM -0.850143417840697 0.189459316150428 no 2748 0.197622677560672 3852 782427
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.851718116222201 0.189027372133109 no 2749 0.197185281596098 3910 6708739 YPR165W RHO1
SGTC_788 1182-0090 188 µM -0.852248638393057 0.188881985183865 no 2750 0.197038053158839 3989 5715185
SGTC_470 aa-861 153 µM -0.85296979678659 0.188684465851032 no 2751 0.196838026826221 3911 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2708 st078559 56 µM -0.854698794194508 0.188211426547842 no 2752 0.19635895912913 3879 17250902
SGTC_1479 0549-0158 134 µM -0.857130404029626 0.187547397855993 no 2753 0.19568640990737 3943 5440202
SGTC_1385 3091-4834 14.1 µM -0.857818524345979 0.187359747759539 no 2754 0.195496339620572 3903 4072814
SGTC_1456 k015-0012 13 µM -0.857875854871146 0.187344118991037 no 2755 0.195480509036437 3914 2989616
SGTC_1924 st058459 75.1 µM -0.858499240915148 0.18717423090473 no 2756 0.195308424730242 3851 688683
SGTC_921 1561-0023 372 µM -0.859570530253746 0.186882500748008 no 2757 0.195012912809096 3879 24050882
SGTC_1365 1672-3266 55.4 µM -0.859917305181856 0.186788128399291 no 2758 0.19491731426309 3933 6415873
SGTC_2730 imipramine 71.33 µM -0.860609455083524 0.186599852901474 no 2759 0.194726588333666 3916 3696 A tricyclic antidepressant.
SGTC_1704 st028805 70.8 µM -0.864006405125649 0.185677534407865 no 2760 0.193792185988455 3956 2876101
SGTC_2277 7947813 106.88 µM -0.866592474591005 0.184977280768402 no 2761 0.193082669129876 4017 1246798
SGTC_791 1348-1292 225 µM -0.866896234857276 0.184895136654334 no 2762 0.192999433344327 3894 5437054
SGTC_1529 apigenin 74 µM -0.868902622187054 0.18435313060395 no 2763 0.192450197602319 3928 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2057 5236571 38.335 µM -0.87114789526852 0.183747765300368 no 2764 0.191836702750294 3926 54684039 YBR257W POP4
SGTC_3007 9078383 71.4286 µM -0.872885126115894 0.183280227951474 no 2765 0.191362847120569 3930 6496995
SGTC_2421 5690543 90.72 µM -0.873945048265018 0.182995338006824 no 2766 0.191074090197191 3983 3397993
SGTC_1391 3442-0225 151 µM -0.874864500958748 0.182748427921 no 2767 0.190823818229213 3893 5227075
SGTC_1398 3558-0053 112 µM -0.876745267255757 0.182244014615323 no 2768 0.190312506770633 3843 4532369
SGTC_2995 9067767 71.4286 µM -0.876954205319411 0.182188032089047 no 2769 0.190255756149677 3983 11673567
SGTC_1879 gemcitabine 100 µM -0.877521241086812 0.182036155620331 no 2770 0.190101793377239 3913 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2439 5492030 7.2 µM -0.878846453917667 0.181681515653721 no 2771 0.189742267423829 3928 5722370
SGTC_2682 pyrogallin 40.03 µM -0.879474277830445 0.181513654828095 no 2772 0.189572086909601 3956 822798 An ATP competetive kinase inhibitor.
SGTC_1131 3454-3128 32.3 µM -0.880448437727501 0.181253386644364 no 2773 0.189308213120353 4015 710982
SGTC_2891 9063876 19.48 µM -0.881035859011746 0.181096557179367 no 2774 0.189149205782624 3932 6472478
SGTC_2738 aclarubicin 5.55 µM -0.881294256441917 0.181027597282198 no 2775 0.189079286996981 3887 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3195 9113082 49.47 µM -0.882355653404196 0.180744509254583 no 2776 0.18879225461483 3856 17018038
SGTC_351 caspofungin 25 nM -0.882408295569252 0.180730476149352 no 2777 0.188778025646526 3950 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2356 9061756 188.97 µM -0.882422773577771 0.18072661678848 no 2778 0.188774112414165 3979 20104043
SGTC_2156 5649887 115 µM -0.884284707771484 0.180230717036994 no 2779 0.188271270600457 3995 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2159 5658611 73.75 µM -0.88479115640491 0.180095979505373 no 2780 0.188134640033543 3914 793844
SGTC_2084 5306078 60.6385 µM -0.88483158286976 0.180085227020032 no 2781 0.188123736351569 3894 679340
SGTC_2451 5856223 45.7 µM -0.886776027381875 0.179568526633801 no 2782 0.187599748311555 3922 2179896
SGTC_539 4859-0462 2.54 µM -0.886933234410058 0.179526792505548 no 2783 0.187557423668865 4003 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_326 k292-0812 17.5 µM -0.887018347957202 0.179504199751388 no 2784 0.187534511122117 3924 3579357
SGTC_456 gingerol 170 µM -0.889195997966488 0.178926766757773 no 2785 0.186948876638615 3958 442793 A herb.
SGTC_962 1254-0300 21.5 µM -0.890315358406473 0.178630408772142 no 2786 0.186648288313505 3932 7340576
SGTC_2861 9024595 19.48 µM -0.890420267101526 0.178602649361413 no 2787 0.186620131920137 3846 16482810
SGTC_159 3970-0959 50 µM -0.893875396433664 0.177689921845083 no 2788 0.185694281528719 4040 6615653
SGTC_728 3030-5151 22.5 µM -0.894117325323384 0.17762612290985 no 2789 0.185629560215811 3989 3125388
SGTC_1037 k284-1091 78.7 µM -0.895121253261182 0.1773615320979 no 2790 0.18536113693392 3923 3334711
SGTC_952 1185-0122 232 µM -0.895387234474673 0.177291472984684 no 2791 0.185290061123063 3896 678600
SGTC_1600 coumarin 106 71.1 µM -0.895460845387621 0.177272087051709 no 2792 0.185270393718993 4034 100336 A hepatotoxic, DNA x-linker.
SGTC_62 0180-0423 3.232 µM -0.896108741038963 0.177101517085511 no 2793 0.185097344524212 3910 30102 YGL099W LSG1
SGTC_581 0958-0271 211 µM -0.896411354969582 0.17702188416095 no 2794 0.185016552498746 3970 4591145
SGTC_2837 9008476 45.46 µM -0.89717580545161 0.176820819623924 no 2795 0.184812556709876 3980 2992805
SGTC_2167 5876490 200 µM -0.897192432277928 0.176816448067387 no 2796 0.184808121347905 4109 686534
SGTC_1701 st028638 40.4 µM -0.897348728552738 0.17677535769554 no 2797 0.184766431083964 3936 3490878
SGTC_1523 st012844 44.7 µM -0.89736484321804 0.176771121484959 no 2798 0.184762133011698 4099 4274103
SGTC_1400 3771-8998 51.5 µM -0.898899944459366 0.176367869536078 no 2799 0.184352978786992 3877 670767
SGTC_2196 6573537 42.6665 µM -0.899784922543256 0.176135661523051 no 2800 0.184117359824396 3992 2903087
SGTC_359 0081-0058 15.9 µM -0.899800075402834 0.176131687273859 no 2801 0.184113327119014 4016 3494159
SGTC_1504 k297-0033 30 µM -0.902251720182449 0.175489424447616 no 2802 0.183461583017634 3892 4388117
SGTC_977 1348-1378 135 µM -0.903069141336496 0.175275613211909 no 2803 0.18324460023982 3968 X977
SGTC_836 0330-0104 1.35 µM -0.903107200581246 0.175265662156789 no 2804 0.183234501391773 3955 46494820
SGTC_265 mycophenolic acid 32.932 µM -0.903646588773187 0.175124671035019 no 2805 0.183091414500499 4046 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_248 streptozotocin 5.23457 mM -0.903850036445864 0.175071510371774 no 2806 0.183037462768483 3976 5300 DNA alkylating agent.
SGTC_42 0133-0086 60.653 µM -0.904120463993297 0.175000863787102 no 2807 0.18296576418326 3864 162923 Model of phenazepam hydroxylation.
SGTC_491 tetrandrine 80.3 µM -0.904305046729327 0.174952653718092 no 2808 0.182916835738989 3993 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.906315140890094 0.174428194852285 no 2809 0.182384536878443 4004 551469
SGTC_2539 epi(13)torulosol 80 µM -0.908132161296934 0.17395497170197 no 2810 0.181904200154921 4028 6708597
SGTC_68 0986-0284 82.829 µM -0.908853229498682 0.173767403821642 no 2811 0.181713802329669 4076 423278 YIL048W NEO1
SGTC_2973 9094665 17.96 µM -0.909772157551229 0.173528554159291 no 2812 0.181471340449257 4045 25237061 YIL048W NEO1
SGTC_1230 0170-0365 3.77 µM -0.911112760721057 0.173180476777938 no 2813 0.181117981767499 4046 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_739 1486-1183 203 µM -0.911148475858216 0.173171209700112 no 2814 0.181108573803411 3984 4346692
SGTC_835 0312-0010 67.2 µM -0.911349383851869 0.173119085587848 no 2815 0.181055656984791 3934 1626196
SGTC_678 1218-2179 85.9 µM -0.914478118502339 0.172308648072307 no 2816 0.180232835246706 3962 6820081 YOR116C RPO31
SGTC_2435 5706476 10.6 µM -0.915534550596546 0.172035547523082 no 2817 0.179955536419359 3982 5725375
SGTC_2453 5731132 22.18 µM -0.916395178996143 0.171813268964703 no 2818 0.179729831503366 4034 1362040
SGTC_811 0416-0114 265 µM -0.919043080502363 0.171130533828182 no 2819 0.179036519623552 4062 6612453
SGTC_3133 9127736 49.47 µM -0.919387079760066 0.171041964549147 no 2820 0.178946572427844 3935 27243420
SGTC_1932 st074806 40.9 µM -0.920358059790162 0.170792125130204 no 2821 0.178692838905876 4092 17251235
SGTC_1446 4239-0190 62 µM -0.920358776666458 0.170791940759635 no 2822 0.178692651657686 4013 1340085
SGTC_2839 9003951 25.97 µM -0.920737096964657 0.170694659834473 no 2823 0.178593851579071 4051 2990634
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.9211851855481 0.170579484649913 no 2824 0.178476875706353 3974 6312947
SGTC_1825 st052143 62.6 µM -0.922188268264666 0.170321836046192 no 2825 0.178215190703063 4028 674173
SGTC_1218 1348-1416 30.7 µM -0.924036158119947 0.169847846002962 no 2826 0.177733745213601 3943 6787668
SGTC_856 0433-0016 11.3 µM -0.92556064116889 0.169457448242636 no 2827 0.177337177795343 4054 3911780
SGTC_3028 9087778 49.47 µM -0.930646540973711 0.168159192698054 no 2828 0.176018215686517 3986 17217395
SGTC_1207 2099-0101 141 µM -0.931951216631052 0.167827187907616 no 2829 0.17568086857425 4031 5837381
SGTC_1590 st077108 57.8 µM -0.935794053693057 0.166851743506054 no 2830 0.174689616832793 4025 5489485
SGTC_630 4356-0227 183 µM -0.93970100885632 0.16586378086058 no 2831 0.173685473760026 3987 779312
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.940100195419218 0.165763050780901 no 2832 0.173583084299898 4022 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2395 5646831 180.19 µM -0.940931035410171 0.16555352483459 no 2833 0.173370100974448 4059 6808628
SGTC_1828 st055811 49 µM -0.941235773274207 0.165476717264333 no 2834 0.173292024059939 4052 5877589
SGTC_2959 9079155 11 µM -0.941525120395983 0.16540381018703 no 2835 0.173217911132658 4080 16189457
SGTC_1746 st038117 42 µM -0.943820074733127 0.164826284536073 no 2836 0.172630800158592 4096 2898218
SGTC_643 k048-0106 28.4 µM -0.944715028494439 0.164601423680009 no 2837 0.172402191206234 4029 6763920
SGTC_105 0111-0055 734.78 µM -0.94489486612439 0.164556262724327 no 2838 0.172356276399108 4034 5179370
SGTC_1074 carmofur 3.8 µM -0.948341927998283 0.163692186332704 no 2839 0.171477706266251 4052 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2479 5617353 43.85 µM -0.948344807096043 0.16369146586143 no 2840 0.171476973654316 4091 2731746
SGTC_896 0964-0007 44.5 µM -0.948346401137218 0.163691066966213 no 2841 0.171476568037275 3968 6756758
SGTC_1984 st072354 53.1 µM -0.94879049121013 0.163579961787889 no 2842 0.171363589504389 3914 5762938
SGTC_973 1325-0077 65.9 µM -0.949832521426966 0.163319452575859 no 2843 0.171098679141614 4039 2835149
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.951890258629073 0.162805807105256 no 2844 0.170576320204365 4019 442882
SGTC_2199 6590217 200 µM -0.952255597575174 0.16271472235799 no 2845 0.170483685339779 3935 703109
SGTC_1245 0418-0076 17.2 µM -0.953938575863656 0.162295557524105 no 2846 0.170057367691669 4098 6790114
SGTC_787 4152-0075 138 µM -0.954796853514449 0.162082064628519 no 2847 0.169840219453374 4046 9566539
SGTC_2402 5553605 200 µM -0.957690706841528 0.161363579618367 no 2848 0.169109372130322 4137 6758546
SGTC_380 3970-0968 6 µM -0.958007502319617 0.161285052070481 no 2849 0.169029487745552 3932 2891601
SGTC_3245 9134821 49.47 µM -0.958132284807107 0.161254127719569 no 2850 0.168998028760745 4036 17014901
SGTC_2747 doxorubicin 7.63 µM -0.959518096622944 0.160910947481763 no 2851 0.168648903775261 3987 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1371 2421-0008 32.7 µM -0.960081170410682 0.160771645093259 no 2852 0.168507182188163 4005 2827552
SGTC_2466 5983409 37.09 µM -0.96062526521937 0.160637112863888 no 2853 0.168370310236866 4060 2879657
SGTC_2177 5811945 192 µM -0.961698771584818 0.160371894675857 no 2854 0.168100469803368 4087 5343475
SGTC_2693 st077581 40.7 µM -0.962463053441266 0.160183247313152 no 2855 0.167908526839049 4098 25238761
SGTC_173 1273-0061 2.693 µM -0.964817161111788 0.159603095851474 no 2856 0.167318199409503 4035 2847414 YPL266W DIM1
SGTC_3125 9127534 49.47 µM -0.965303454650638 0.159483424191932 no 2857 0.167196420985327 3932 1639235
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.967489119143682 0.158946280925035 no 2858 0.166649789027101 4056 77254
SGTC_3122 9126309 49.47 µM -0.967746401364838 0.158883129989997 no 2859 0.166585519023153 4092 17591206
SGTC_392 N-ethylmaleimide 8.33 µM -0.968395671029132 0.15872383731205 no 2860 0.166423400314245 3996 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3166 9102297 49.47 µM -0.969345693422128 0.158490946308257 no 2861 0.166186369104076 4060 25237072
SGTC_2111 5486399 200 µM -0.970183812792397 0.158285673683946 no 2862 0.165977438916834 4019 689674
SGTC_401 neomycin 50 µM -0.970256455707285 0.158267890163037 no 2863 0.165959338159597 4028 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_9 0092-0002 10.449 µM -0.971333046237567 0.158004486567303 no 2864 0.165691228881929 4026 759368
SGTC_2649 anisomycin 9.56 µM -0.972144362970876 0.157806176356459 no 2865 0.165489367358499 4051 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3302 9125395 16.351 µM -0.972524366740753 0.157713348243893 no 2866 0.165394874375163 4006 17599668
SGTC_3201 9113999 49.47 µM -0.974190298989542 0.157306814250507 no 2867 0.164981030261074 4094 16649224
SGTC_15 0266-0086 27.098 µM -0.975152692699819 0.157072277530126 no 2868 0.164742262150655 4116 1712902 YIL048W NEO1
SGTC_1197 1601-0112 267 µM -0.980866744809392 0.155684493766882 no 2869 0.163329229337127 4035 7350313
SGTC_3214 9129694 49.47 µM -0.985896804209627 0.154469545402939 no 2870 0.162091877639396 4116 17158655
SGTC_1742 st038235 28.8875 µM -0.989701844957065 0.153554660119387 no 2871 0.161159936480465 4128 564103 YBR002C RER2
SGTC_3224 9130643 49.47 µM -0.990475052644599 0.153369189378137 no 2872 0.160970988529038 4134 17644395
SGTC_3108 9121785 49.47 µM -0.993360671717634 0.152678321568128 no 2873 0.160267110084072 3932 17140271
SGTC_1765 st044815 90.4 µM -0.993831775310877 0.152565727440669 no 2874 0.160152386828828 4127 645695
SGTC_469 w7 172 µM -1.00038306827345 0.151005674156559 no 2875 0.158562580377339 4155 45115570 A P450 inhibitor.
SGTC_2337 9009472 200 µM -1.00073436285815 0.150922321666361 no 2876 0.158477624864655 4050 5742383
SGTC_2847 9005661 71.43 µM -1.00161537468323 0.1507134166522 no 2877 0.158264696252332 4081 2991449
SGTC_115 0527-0192 112.043 µM -1.00210391654062 0.150597656917338 no 2878 0.158146703258849 4085 4233931
SGTC_2239 6685329 187.64 µM -1.00400415365237 0.150147959978579 no 2879 0.15768830575406 4145 805680
SGTC_1868 st057644 42.7 µM -1.00466464104345 0.149991863461299 no 2880 0.157529179854517 4099 688665
SGTC_2505 galangin 7.89 µM -1.00488768480724 0.149939174784898 no 2881 0.157475467561239 3979 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2496 diffractaic acid 79.83 µM -1.00661980920914 0.149530422562234 no 2882 0.157058755667568 4124 94870 An apoptosis inducer which activates caspases.
SGTC_975 1335-0046 28.5 µM -1.00662515427442 0.149529162368789 no 2883 0.157057470883306 4109 16486740
SGTC_1238 0333-0287 48.8 µM -1.00928054180808 0.148903984266471 no 2884 0.156420054639406 4067 7226
SGTC_2904 7225135 42.03 µM -1.01252665713719 0.148142102424633 no 2885 0.155643153809826 4213 4446116
SGTC_2142 5622915 118.518 µM -1.01296845084427 0.148038612939307 no 2886 0.155537615320934 4125 5322196
SGTC_234 nsc-17383 10.7 µM -1.01317293001685 0.147990730396852 no 2887 0.155488784021962 4108 408974
SGTC_576 1073-0113 22.7 µM -1.01688963216924 0.147122203185945 no 2888 0.154602968008462 4244 5439563
SGTC_869 0564-0080 44.1 µM -1.01727507084614 0.147032328998533 no 2889 0.154511296161632 4113 6843321
SGTC_948 3448-0295 75.3 µM -1.01777326819887 0.146916217003535 no 2890 0.154392859296069 4090 678569
SGTC_2423 st077119 87.2 µM -1.01777646607639 0.146915471891299 no 2891 0.154392099255952 4034 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_641 4092-0595 30 µM -1.01846616148487 0.146754830620364 no 2892 0.154228237023971 4140 786260
SGTC_1255 0566-0045 221 µM -1.02018084734131 0.146355963274269 no 2893 0.153821349645008 4142 2788469
SGTC_6 0844-0013 19.835 µM -1.02298136712421 0.145706077644994 no 2894 0.153158327880203 4237 1584900
SGTC_2288 7946289 167.31 µM -1.02353376870286 0.145578117348326 no 2895 0.153027771035752 4182 1246052
SGTC_755 1995-0008 37.3 µM -1.02356878367844 0.145570008900385 no 2896 0.15301949794059 4076 689533
SGTC_992 3909-8734 162 µM -1.02386348224931 0.145501777333379 no 2897 0.152949880358836 4122 4288319
SGTC_1667 st014849 34.6 µM -1.02427741204967 0.145405976483754 no 2898 0.1528521318717 4160 5348460
SGTC_3289 9119912 71.43 µM -1.02591601575315 0.145027150827532 no 2899 0.15246558636797 4169 17014829
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.02960520727836 0.144176687169901 no 2900 0.151597684914282 4068 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_355 1311-2252 105 µM -1.03120060140882 0.143809946950387 no 2901 0.151223379346819 4108 5338538
SGTC_1183 1254-0324 198 µM -1.03143760462626 0.143755519726405 no 2902 0.151167827006923 4206 5799357
SGTC_2286 7945697 125 µM -1.03219167383442 0.143582442000556 no 2903 0.150991167375443 4154 1245733
SGTC_644 1498-1197 63.3 µM -1.03327854260702 0.143333226009766 no 2904 0.150736782920797 4160 6741615
SGTC_1252 0493-0875 34.8 µM -1.03388441777262 0.143194427392604 no 2905 0.15059510021415 4119 3960963
SGTC_403 arphamenine a 50 µM -1.03460590166409 0.143029262685603 no 2906 0.150426498368129 4092 5487158 An arginine aminopeptidase inhibitor.
SGTC_2811 7967822 32.47 µM -1.03812444130446 0.142225630840821 no 2907 0.149606061939857 4184 2232244
SGTC_3132 9126706 49.47 µM -1.03865996089185 0.142103586998613 no 2908 0.149481454320744 4220 850858
SGTC_94 0334-0113 514.748 µM -1.04076689365204 0.141624109428326 no 2909 0.148991874273561 4154 6795178
SGTC_3215 9129942 49.47 µM -1.04185877907086 0.14137605922838 no 2910 0.148738578851823 4129 17682944
SGTC_2717 st081029 62.2815 µM -1.04199160839927 0.141345903689973 no 2911 0.148707784771589 4118 5292846
SGTC_1674 st016616 23.6 µM -1.04265610975025 0.14119511093375 no 2912 0.148553796126575 4082 625830
SGTC_1503 4585-0012 61.3 µM -1.04475892713787 0.140718645499597 no 2913 0.148067201139222 4192 2922052
SGTC_2820 7989630 71.43 µM -1.04620696821843 0.140391177182638 no 2914 0.147732743202791 4147 2984098
SGTC_549 1661-1316 519 µM -1.04704014923885 0.140202991552365 no 2915 0.147540530619784 4174 2857282
SGTC_1487 3970-0795 2.82 µM -1.04762944458944 0.140069994422078 no 2916 0.147404682990889 4177 3765103
SGTC_43 0570-0105 72.5 µM -1.04885584298175 0.139793485414637 no 2917 0.147122235638632 4137 1114046 YDL195W SEC31
SGTC_3352 9151559 45.5865 µM -1.05419959172553 0.138592993648896 no 2918 0.145895773467855 4152 17159339
SGTC_2823 7987624 58.44 µM -1.05650673547228 0.138076862994897 no 2919 0.145368382626957 4155 2239440
SGTC_175 3793-3120 23.7 µM -1.06021057565984 0.137251021985889 no 2920 0.144524405441753 4166 5322297
SGTC_1201 1889-3372 45.9 µM -1.06028171750649 0.137235192661686 no 2921 0.144508227054275 4022 5392199
SGTC_2828 7998861 71.43 µM -1.06326607948484 0.136572284232971 no 2922 0.143830651633537 4135 2988188
SGTC_1803 st050068 52.4 µM -1.06335159607464 0.136553320988371 no 2923 0.143811267419711 4209 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3235 9132602 49.47 µM -1.06494567869661 0.136200163891165 no 2924 0.143450256209632 4174 4912240
SGTC_1845 st056753 3.01 µM -1.06817654726074 0.135486307658632 no 2925 0.142720440895252 4136 5375839
SGTC_2350 9023895 38.85 µM -1.06833235664612 0.135451946698604 no 2926 0.142685308942491 4187 2997209
SGTC_328 k915-0120 63.5 µM -1.06945699220621 0.135204105657475 no 2927 0.14243189915866 4149 6624543
SGTC_104 0074-0074 590.992 µM -1.07394958293986 0.13421715584269 no 2928 0.141422639390245 3943 3943124
SGTC_1397 3532-0190 20.1 µM -1.07691701267329 0.13356797954114 no 2929 0.140758670973824 4115 5322280
SGTC_1886 st057356 49.9 µM -1.07802513117518 0.133326114178843 no 2930 0.14051127051059 4131 24207747
SGTC_2168 5727979 200 µM -1.0795284166256 0.132998478947259 no 2931 0.140176116516377 4069 695210
SGTC_2315 7733312 200 µM -1.08468898041606 0.131877973317431 no 2932 0.139029715052996 4081 726316
SGTC_1967 st070177 51.4 µM -1.08514195942361 0.1317799304675 no 2933 0.138929392907485 4222 5729214
SGTC_1720 st037298 9.481 µM -1.08524332979459 0.131757996735942 no 2934 0.138906948964489 4183 597396
SGTC_1163 k060-0048 49.9 µM -1.08585077663184 0.131626614891053 no 2935 0.138772508705693 4170 6809982
SGTC_1154 4088-0362 150 µM -1.08738660207875 0.131294841735747 no 2936 0.138432994882516 4180 6618304
SGTC_1327 1436-0082 2.18 µM -1.08825612075972 0.131107262202289 no 2937 0.138241027853449 4189 15992205
SGTC_2195 6536160 144.242 µM -1.08894880754502 0.13095796280472 no 2938 0.138088230625362 4141 3834386
SGTC_1633 st005664 67.9 µM -1.08994884010936 0.130742626421795 no 2939 0.137867840351349 4178 2063822
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.0944082399883 0.129785366604798 no 2940 0.136887985818686 4318 16725076
SGTC_510 ag-490 170 µM -1.09818717170496 0.128977984632443 no 2941 0.136061383348023 4311 5328779
SGTC_2275 7947463 200 µM -1.09847860911381 0.12891586300179 no 2942 0.135997776625791 4165 1225414
SGTC_2659 sanguinarine 24.21 µM -1.09936172583775 0.128727748106559 no 2943 0.135805159177559 4144 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1308 1187-1617 41.4 µM -1.10504091984356 0.127522559477437 no 2944 0.134570929293682 4217 2882570
SGTC_2257 7960413 200 µM -1.10604161901232 0.127311015577226 no 2945 0.134354252907981 4223 2974689 YIL048W NEO1
SGTC_244 nsc-207895 1.295 µM -1.10729154542901 0.127047129040735 no 2946 0.134083949251351 3973 42640
SGTC_1015 4130-4525 82 µM -1.10778015817815 0.12694407586699 no 2947 0.133978385622389 4205 1363237
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.11187265373419 0.126083213215631 no 2948 0.133096454001041 4185 676296 Flavone; oxidizing agent.
SGTC_2627 acetyl isogambogic acid 100 µM -1.11247407821711 0.125957046479602 no 2949 0.132967184723441 4230 6857789 A caspase activator and apoptosis inducer.
SGTC_1814 st052110 31.539 µM -1.11368550278065 0.125703181341169 no 2950 0.132707065405028 4148 674163
SGTC_125 0133-0007 11.75 µM -1.11495122427309 0.125438319323893 no 2951 0.132435661980965 4293 26541
SGTC_1164 k060-0068 93.7 µM -1.11634851189419 0.125146378716096 no 2952 0.13213649185477 4203 5963676
SGTC_1345 1488-0192 31.4 µM -1.11635704389092 0.125144597552326 no 2953 0.132134666520519 4258 658348
SGTC_1338 1486-1223 76 µM -1.11878306991581 0.124638851528809 no 2954 0.131616348015041 4222 3444526
SGTC_202 3594-0513 34.79 µM -1.12741458755794 0.122851056873004 no 2955 0.129783617142222 4260 708429
SGTC_1499 4480-0877 67.3 µM -1.12799022491211 0.122732471446593 no 2956 0.12966202370705 4181 2861909
SGTC_3178 9107506 49.47 µM -1.13099125355552 0.122115538426536 no 2957 0.129029386392412 4223 8897194
SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.13149717288848 0.122011749504324 no 2958 0.128922946336611 4213 140250 A respiratory chain inhibitor.
SGTC_117 lucigenin 22.078 µM -1.13250193485067 0.121805807172769 no 2959 0.128711735698047 4225 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2175 5807670 165.306 µM -1.13261750076806 0.121782135724874 no 2960 0.128687458033088 4196 241186
SGTC_1442 4112-3290 3 µM -1.13312056417249 0.121679130553035 no 2961 0.128581813334676 4212 704353
SGTC_571 k831-0106 44.2 µM -1.13858965532706 0.12056325195828 no 2962 0.127437172547287 4098 4783639
SGTC_2126 5251174 33.877 µM -1.13903389418048 0.12047292973949 no 2963 0.127344508763344 4239 790722
SGTC_646 4092-0839 27.3 µM -1.14210990934446 0.119848824572849 no 2964 0.126704168488654 4257 877796
SGTC_2292 7671323 168.05 µM -1.14231889315923 0.119806505848899 no 2965 0.126660745395242 4293 937504
SGTC_804 1595-0054 20.9 µM -1.14523176869568 0.119217752166767 no 2966 0.126056580841345 4176 761523 Stimulates phospholipase C.
SGTC_2840 9008771 71.43 µM -1.14532894635301 0.119198145772708 no 2967 0.126036459746884 4181 2992978
SGTC_1301 naphtanilide LB 4.81 µM -1.14590229220879 0.119082514844088 no 2968 0.125917791350317 4300 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2587 piperic acid 92.2 µM -1.14627548988715 0.119007291852668 no 2969 0.125840590548471 4226 5370536
SGTC_2365 9042475 200 µM -1.15105229326027 0.118047425409228 no 2970 0.124855361398219 4301 6464479
SGTC_3257 9139206 32.98 µM -1.15223210509866 0.11781119579889 no 2971 0.12461285408828 4238 4910041
SGTC_1415 3966-0071 78.1 µM -1.15321485721552 0.117614678294304 no 2972 0.124411103406526 4177 2893185
SGTC_2221 6807166 181.081 µM -1.15360245668253 0.117537235226212 no 2973 0.124331595361742 4214 674925
SGTC_665 3914-0008 307 µM -1.1537188792626 0.117513980837937 no 2974 0.12430772060967 4192 1069549
SGTC_1057 3448-5381 134 µM -1.15393227865942 0.11747136463961 no 2975 0.124263967169313 4227 5497911
SGTC_178 4092-0806 87.505 µM -1.15462493451249 0.117333115571213 no 2976 0.124122025641908 4141 2169044
SGTC_214 4373-3496 70 µM -1.15540679075632 0.117177201243686 no 2977 0.123961941182692 4329 3779166
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.1568926568389 0.116881301008534 no 2978 0.123658109610912 4300 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2764 methyldopa 94.69 µM -1.15720119725702 0.116819923724669 no 2979 0.123595084355716 4249 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_803 4488-1585 147 µM -1.15850220534298 0.116561368270649 no 2980 0.123329576108438 4231 747204
SGTC_999 SEC7.066 22.7 µM -1.16272731362092 0.115724492615759 no 2981 0.122470078035856 4207 740511 YDR170C SEC7
SGTC_1882 5615643 20 µM -1.1628142265197 0.115707322516509 no 2982 0.122452441899685 4204 2253075
SGTC_1610 st001799 48.1 µM -1.1634869614598 0.115574481405096 no 2983 0.122315992584945 4198 621897
SGTC_1109 tnp00067 928.257 nM -1.16412684815922 0.115448227226713 no 2984 0.122186304872893 4252 676295
SGTC_2972 9093619 59.92 µM -1.16539760233982 0.115197789074647 no 2985 0.121929043697303 4209 25236256
SGTC_290 2043-6722 48.1 µM -1.16623357581882 0.115033247548112 no 2986 0.12176001045894 4270 773758 YLR208W SEC13
SGTC_1961 st076550 68.7 µM -1.16639960705827 0.115000588144582 no 2987 0.121726458668391 4284 1579337
SGTC_891 0929-0073 133 µM -1.1668885347197 0.114904451259281 no 2988 0.121627693319528 4289 5603632
SGTC_322 k048-0136 19.3 µM -1.16839006364958 0.114609565971918 no 2989 0.121324730560945 4319 6823282
SGTC_2742 clothiapine 36.27 µM -1.16991460903875 0.114310711913808 no 2990 0.121017667097152 4285 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3021 9087658 49.47 µM -1.17101750832295 0.114094858620995 no 2991 0.120795869821358 4254 25237042
SGTC_309 k408-0051 1.48 µM -1.17275359716972 0.11375566949566 no 2992 0.120447315631655 4176 3640463
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.17322662118435 0.113663376936784 no 2993 0.120352469612057 4164 17037758
SGTC_1424 4048-1941 275 µM -1.17485819662759 0.1133454469692 no 2994 0.120025726237202 4336 X1424
SGTC_410 α-linolenic acid 100 µM -1.17516430983033 0.113285868266092 no 2995 0.119964492963922 4304 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_72 0744-0168 198.391 µM -1.17574175745742 0.113173540666458 no 2996 0.11984904333701 4150 677577
SGTC_1262 0737-0114 49.6 µM -1.17851316195312 0.112635541052499 no 2997 0.11929604412817 4310 765919
SGTC_2639 lactacystin 53 µM -1.17858978085822 0.11262069337832 no 2998 0.119280781403943 4310 3870 A proteasome inhibitor.
SGTC_2739 tacrine 100.86 µM -1.18308181857211 0.111752641202839 no 2999 0.118388361365339 4332 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2063 5246145 200 µM -1.18435131247328 0.11150819080867 no 3000 0.118137012308689 4305 711240
SGTC_1611 st001856 99.4 µM -1.1859947269774 0.1111923078753 no 3001 0.117812190958286 4240 647478
SGTC_304 1310-0298 97 µM -1.18774922872084 0.110855780405875 no 3002 0.11746611123521 4056 1550234
SGTC_1851 st056236 18.9 µM -1.18850360192924 0.110711310132666 no 3003 0.117317530793877 4271 5393171
SGTC_766 1391-0721 126 µM -1.18902844700882 0.110610876491937 no 3004 0.11721423648581 4299 1020919 YIL115C NUP159
SGTC_1111 tnp00062 510.699 nM -1.19089818673476 0.110253616375768 no 3005 0.116846778239831 4325 676306
SGTC_2999 9069765 71.4286 µM -1.19184814815294 0.110072420079164 no 3006 0.116660396331015 4237 2097066
SGTC_2149 5554786 194.827 µM -1.19450484895799 0.109566813583624 no 3007 0.116140272538301 4321 745063 YPR165W RHO1
SGTC_2061 5245884 80.95 µM -1.19642086398133 0.109203206236609 no 3008 0.11576618171487 4266 573863
SGTC_608 k048-0125 159 µM -1.19967728690487 0.108587216549874 no 3009 0.115132348738979 4324 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3260 9137109 49.47 µM -1.19990408635153 0.108544408122798 no 3010 0.115088296386576 4230 17478346
SGTC_2766 oltipraz 83.91 µM -1.20425216172885 0.107726054568878 no 3011 0.114246065243434 4262 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_247 mechlorethamine 29.705 µM -1.20536250583939 0.107517790403246 no 3012 0.114031694622629 4204 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_123 0083-0120 66.675 µM -1.20538350971251 0.107513853563322 no 3013 0.114027642234869 4268 16001701
SGTC_816 0325-0417 81.3 µM -1.20909476382363 0.106819868351083 no 3014 0.113313220326101 4313 68101
SGTC_883 0850-0245 24.6 µM -1.20955580317236 0.106733882613732 no 3015 0.113224693020282 4370 6823229 YPR165W RHO1
SGTC_731 3966-0296 387 µM -1.21578905600215 0.10557625498674 no 3016 0.112032644422263 4297 660956
SGTC_1755 st041960 45.185 µM -1.2167440768983 0.10539969552747 no 3017 0.111850801631695 4328 2257073
SGTC_3262 9137218 49.47 µM -1.21706745807247 0.105339958875211 no 3018 0.111789275414572 4230 17650664
SGTC_884 0851-0618 334 µM -1.22150383539215 0.104522919839889 no 3019 0.110947657165854 4319 9642473
SGTC_1298 1079-1278 263 µM -1.22578547763096 0.103738741165257 no 3020 0.110139706790821 4281 2840950
SGTC_149 3970-0822 46.1 µM -1.22655787270154 0.103597733366502 no 3021 0.10999440554286 4285 3114250 YBL034C STU1
SGTC_2497 7-hydroxyflavone 100 µM -1.226560140137 0.103597319630223 no 3022 0.109993979200498 4313 5281894
SGTC_1922 5578187 25 µM -1.22715032869409 0.103489669388286 no 3023 0.109883047282125 4330 1350412
SGTC_2489 cantharidin 73.42 µM -1.22795539534899 0.103342956376495 no 3024 0.109731856342162 4256 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_81 0411-0046 9.971 µM -1.22816424507104 0.103304920887178 no 3025 0.109692658920654 4274 12925265
SGTC_457 grayanotoxin iii 135 µM -1.22829363265193 0.103281362057838 no 3026 0.109668380189476 4157 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1310 1188-0297 994 nM -1.22919193558241 0.103117907033342 no 3027 0.109499925902403 4186 1588352
SGTC_750 4073-0104 132 µM -1.22970806921887 0.103024076484312 no 3028 0.109403222021449 4026 22330957
SGTC_1766 st045414 44.774 µM -1.23073537426163 0.102837502092354 no 3029 0.109210926582093 4313 253960
SGTC_2537 larixol 68.93 µM -1.230741298706 0.10283642683464 no 3030 0.109209818323503 4290 6708759
SGTC_1958 st076513 41.9 µM -1.23272063810061 0.102477643550864 no 3031 0.108840004614047 4263 732122 YGL099W LSG1
SGTC_3027 9089541 49.47 µM -1.23535235327399 0.102002018618661 no 3032 0.108349698631142 4310 9943819
SGTC_3304 9125678 46.087 µM -1.23709086505665 0.101688702979133 no 3033 0.10802667537252 4247 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2908 7930301 100 µM -1.23730169200558 0.101650755310402 no 3034 0.107987549975288 4281 2223178
SGTC_96 0929-0093 37.281 µM -1.23744709280838 0.101624589989657 no 3035 0.107960572349171 4324 6991579
SGTC_530 4358-1714 28 µM -1.23867536639438 0.101403754064238 no 3036 0.107732872440958 4317 1564641
SGTC_2977 9011197 71.43 µM -1.24156048341341 0.100886403393574 no 3037 0.107199384664326 4382 2704722
SGTC_2794 7785382 27.27 µM -1.24450452434031 0.100360473191875 no 3038 0.106656967629583 4311 2205081
SGTC_1459 k035-0031 35.7 µM -1.25049849076018 0.0992958865914955 no 3039 0.105558753150202 4054 3877128 YMR208W ERG12
SGTC_1539 benzyladenosine 56 µM -1.25064107636893 0.0992706629327118 no 3040 0.105532728565469 4316 92208 A nucleotide analog.
SGTC_2955 9076254 12.21 µM -1.25119971327439 0.0991718841615311 no 3041 0.105430811410594 4238 16459619
SGTC_48 0382-0018 55 µM -1.25489611523311 0.0985200932494879 no 3042 0.104758237213542 4377 762596
SGTC_2445 5742597 35.57 µM -1.25525044582035 0.0984577788345141 no 3043 0.104693929001366 4333 1774255
SGTC_871 0574-0004 149 µM -1.25734798558633 0.0980894856117119 no 3044 0.104313827582056 4292 9551173
SGTC_3233 9132340 49.47 µM -1.25845445933457 0.0978956142993427 no 3045 0.104113723590752 4338 17682950
SGTC_3144 9087057 49.47 µM -1.26037206370068 0.0975602857412782 no 3046 0.103767587288394 4254 17249618
SGTC_59 0330-0160 1.33 µM -1.26561859812273 0.0966471387108028 no 3047 0.102824832161864 4297 4293482
SGTC_1534 6-azauridine 81.6 µM -1.26725150525468 0.0963642200910214 no 3048 0.102532687269603 4371 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_694 1315-0438 43.2 µM -1.26803548951289 0.0962286028918275 no 3049 0.10239263854353 4355 6793154
SGTC_423 5-fluorouracil 457 µM -1.26831975132367 0.0961794646500097 no 3050 0.10234189319735 4275 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2884 9058502 51.95 µM -1.26965469911165 0.0959489487769801 no 3051 0.102103827974153 4364 6471554
SGTC_2900 5328528 85.29 µM -1.27429255154229 0.0951512524729143 no 3052 0.101279877627906 4351 795359
SGTC_767 0929-0023 86 µM -1.27430540331367 0.0951490488142619 no 3053 0.101277601162051 4367 1204563
SGTC_969 1313-0238 134 µM -1.27508160788878 0.0950160247807141 no 3054 0.101140179251979 4368 5212874
SGTC_2666 tannic acid 100 µM -1.27532688919814 0.0949740175703168 no 3055 0.101096782079706 4332 16134267 A thiamine antagonist.
SGTC_2140 5586273 200 µM -1.28181573906883 0.0938676915047851 no 3056 0.0999536458347856 4317 854421
SGTC_3076 9116187 49.47 µM -1.28216120232193 0.0938090590500096 no 3057 0.0998930515529539 4332 27241210
SGTC_2707 st078556 66.6 µM -1.28438287563638 0.0934326397219238 no 3058 0.0995040108499976 4289 17250899
SGTC_781 4335-2806 94.4 µM -1.28687139022462 0.0930123353776382 no 3059 0.0990695593424358 4405 845254
SGTC_3314 9135860 59.4275 µM -1.28912596763934 0.0926327506570654 no 3060 0.0986771485845089 4344 25252478
SGTC_3335 9143315 29.6265 µM -1.29065456144214 0.092376046421137 no 3061 0.0984117436822928 4352 4899691
SGTC_1979 st071809 45.3 µM -1.29091199541777 0.0923328661180341 no 3062 0.098367097713681 4398 4976333
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.2927549737615 0.0920241730782858 no 3063 0.0980479088768764 4327 756377
SGTC_2298 7976326 193.81 µM -1.29288988868454 0.0920016053104452 no 3064 0.0980245725572769 4280 2235818
SGTC_1867 st057372 64 µM -1.2929737955529 0.0919875719344634 no 3065 0.0980100611860222 4313 688837
SGTC_1381 2324-0066 62.1 µM -1.29556541760464 0.0915549048469162 no 3066 0.0975626249751814 4394 10885928
SGTC_2544 sphondin 68.51 µM -1.29603762825885 0.0914762327404933 no 3067 0.0974812607349722 4318 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1006 4099-6547 255 µM -1.29768499572186 0.0912021672951534 no 3068 0.0971978008175476 4367 3146833
SGTC_99 0109-0120 622.8 µM -1.2990125394449 0.0909817529548157 no 3069 0.0969698129431764 4357 759414
SGTC_453 enantio-paf c16 10 µM -1.29965357496399 0.090875462318169 no 3070 0.0968598643249991 4067 13871343 A lipid and platelet activating factor
SGTC_683 panaxydol 45 µM -1.2997210646819 0.0908642771541975 no 3071 0.0968482940054298 4372 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1360 1598-0022 39.8 µM -1.30185678300779 0.0905108490199581 no 3072 0.0964826742010626 4407 761525
SGTC_298 1391-0729 10 µM -1.30269457483296 0.0903724865706096 no 3073 0.0963395274742051 4303 3237558
SGTC_2473 5854593 8.94 µM -1.30550932505798 0.0899087770937313 no 3074 0.0958597369710817 4275 2872951
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.30981342027784 0.0892031317268993 no 3075 0.095129481007883 4392 5106787 A p450 inhibitor.
SGTC_1945 st075991 56.6 µM -1.3136525762306 0.0885771966019028 no 3076 0.0944815734701667 4349 1084980
SGTC_1240 0356-0016 42.1 µM -1.31466235728222 0.0884131068628335 no 3077 0.0943117014417204 4350 4305613
SGTC_2147 5545932 89.7195 µM -1.31513986457195 0.0883355907025193 no 3078 0.0942314505050216 4413 797404
SGTC_2219 9098279 200 µM -1.31653593542159 0.0881092500074601 no 3079 0.0939971126566408 4317 902349
SGTC_1934 st074720 32.6 µM -1.31832698804627 0.0878195056418094 no 3080 0.0936971051425184 4317 17250992
SGTC_8 0354-0001 70 µM -1.31889797188436 0.0877272853051641 no 3081 0.0936016121426158 4373 4993152
SGTC_1016 4226-1401 38 µM -1.32022459595455 0.0875132994934005 no 3082 0.0933800211667681 4377 2901613
SGTC_924 2046-0044 21.3 µM -1.32772115934886 0.0863114111408765 no 3083 0.092135120375704 4373 3623589
SGTC_3095 9117207 49.47 µM -1.3290250182951 0.0861036359170422 no 3084 0.0919198580172726 4374 17015229
SGTC_2784 7567673 72.73 µM -1.33238316168051 0.0855702253462962 no 3085 0.0913671561828904 4315 3471247
SGTC_857 0438-0306 1.35 µM -1.34117337360618 0.0841857000878337 no 3086 0.089932084568755 4453 4686136
SGTC_832 4083-0019 164 µM -1.34153220829435 0.0841295402314887 no 3087 0.0898738598712783 4480 1990758
SGTC_1512 0259-0544 12.2 µM -1.34286983268428 0.0839204415159994 no 3088 0.0896570631354939 4364 18476
SGTC_1841 st054148 70 µM -1.34540542932269 0.083525146110248 no 3089 0.089247171448795 4429 675442
SGTC_2463 5473429 200 µM -1.34897795314383 0.0829705722383834 no 3090 0.0886720238212515 4392 5399405
SGTC_805 3852-0218 479 µM -1.35016568467341 0.0827868118418091 no 3091 0.0884814213499465 4377 6615355
SGTC_1292 0kpi-0043 232 µM -1.35041953687067 0.0827475767393965 no 3092 0.0884407237712677 4428 3333905
SGTC_2172 5754775 163.918 µM -1.35047824599918 0.082738504716856 no 3093 0.0884313135112178 4389 2263357
SGTC_2583 asiatic acid 100 µM -1.35830629507194 0.0815355676651264 no 3094 0.0871832568078335 4418 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3149 9097855 49.47 µM -1.35924119454635 0.0813927877416501 no 3095 0.0870350857411372 4410 25236625 YMR079W SEC14
SGTC_679 0422-0091 41.4 µM -1.35983395961921 0.0813023570861999 no 3096 0.0869412366179032 4445 627384 YHR062C RPP1
SGTC_692 k241-0027 77.8 µM -1.35984675477488 0.081300405927474 no 3097 0.0869392116675062 4433 3600480
SGTC_212 3807-4682 38.772 µM -1.36156596033489 0.0810385619709839 no 3098 0.0866674519578934 4470 3125501 YBL034C STU1
SGTC_2026 5148700 152 µM -1.36292301829917 0.0808323248624697 no 3099 0.0864533867064022 4387 79838
SGTC_2469 5655019 90.81 µM -1.36384704929648 0.0806921233981014 no 3100 0.0863078544522441 4461 2788239
SGTC_723 4182-0001 115 µM -1.36453882846308 0.0805872813260941 no 3101 0.0861990211822561 4424 744821 YLR208W SEC13
SGTC_522 1273-0010 11.6 µM -1.36478287719509 0.0805503192658139 no 3102 0.0861606510337746 4447 5705015
SGTC_1199 1638-0010 4.46 µM -1.36512858933727 0.0804979818361566 no 3103 0.0861063188983781 4397 3111136
SGTC_406 estrone 100 µM -1.3656762146549 0.0804151293139781 no 3104 0.0860203065437787 4381 5870 A steroid.
SGTC_2714 st079313 56.9 µM -1.36700717883399 0.0802140307917547 no 3105 0.0858115276808085 4399 2939799
SGTC_1764 st044502 93.5 µM -1.37007150953637 0.0797524790825011 no 3106 0.0853322901820122 4439 8407
SGTC_2341 7987486 176.74 µM -1.37041061778277 0.079701526060386 no 3107 0.0852793797484062 4433 1258686
SGTC_556 4058-0063 51.5 µM -1.37237661015526 0.0794066092003352 no 3108 0.084973113809043 4460 6615692
SGTC_1265 0819-1001 68.8 µM -1.37540836424712 0.0789534383141914 no 3109 0.0845024386546044 4367 3106768
SGTC_2048 5246248 200 µM -1.37772101148364 0.0786090749623468 no 3110 0.084144720773724 4432 677046
SGTC_391 gliotoxin 8.33 µM -1.37783331861446 0.0785923809657364 no 3111 0.0841273782090304 4476 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_249 wiskostatin 11.211 µM -1.37879262795351 0.0784498930380464 no 3112 0.0839793501620868 4394 2775510 A n-wasp and actin depolymerizer.
SGTC_3308 9128332 17.569 µM -1.37987831646493 0.0782888701337017 no 3113 0.0838120569596589 4400 17332805 YDL196W YDL196W
SGTC_1834 st055981 52.8 µM -1.38425346784097 0.0776425129604831 no 3114 0.083140428348366 4412 471719 YDL150W RPC53
SGTC_2595 hexamethylquercetagetin 100 µM -1.38484459574572 0.0775554950394617 no 3115 0.0830499956522853 4416 386331
SGTC_488 nitrendipine 139 µM -1.38527833650564 0.0774916926600228 no 3116 0.0829836876313172 4449 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_411 enrofloxacin 100 µM -1.38580398755511 0.0774144238980458 no 3117 0.0829033822278189 4461 71188 A bacterial gyrase inhibitor.
SGTC_2406 ethylparaben 405.7 µM -1.38615433163001 0.0773629571205132 no 3118 0.0828498915122094 4397 8434 A possible steroid mimic.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.38889131870388 0.0769617783265067 no 3119 0.0824329003838335 4470 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2933 9026794 32.47 µM -1.39214202423727 0.076487356986141 no 3120 0.081939697356227 4362 17586027
SGTC_1318 1280-3875 124 µM -1.39302662879471 0.0763586400355955 no 3121 0.081805869186503 4429 373245
SGTC_1025 k007-0731 70 µM -1.39527121301155 0.0760327750399435 no 3122 0.081467034737523 4397 6256118
SGTC_273 hydroxyurea 18.1 mM -1.39838968265406 0.0755817995151533 no 3123 0.0809980398519282 4492 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1210 3013-0140 750 nM -1.40063921989435 0.0752577515273119 no 3124 0.0806609932780149 4451 905973
SGTC_647 0140-0236 81 µM -1.40232463891086 0.0750156601694084 no 3125 0.0804091630233237 4450 990837
SGTC_3069 9117009 49.47 µM -1.4030661367815 0.0749093407200457 no 3126 0.0802985589847783 4426 41904981
SGTC_2352 9027995 87.8 µM -1.40489932535024 0.0746469829360616 no 3127 0.0800256086198666 4396 2997347
SGTC_204 PMA1.184 62.41 µM -1.40675739220246 0.0743817808660994 no 3128 0.0797496704496839 4403 2252213 YGL008C PMA1
SGTC_2737 bleomycin 30.5 nM -1.40881649632641 0.0740887257469779 no 3129 0.0794447179956804 4533 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1792 st045773 43.6 µM -1.40890036642481 0.0740768079366751 no 3130 0.0794323156009001 4408 2919270
SGTC_1571 st070080 73.4 µM -1.40968398822489 0.0739655272557524 no 3131 0.0793165073542032 4425 4315245
SGTC_1364 1653-0028 37.6 µM -1.4111801023294 0.0737534216572967 no 3132 0.0790957578241576 4440 5718652
SGTC_2064 5220758 200 µM -1.41264880355754 0.0735456549358578 no 3133 0.0788795058843803 4482 788518
SGTC_3111 9122088 49.47 µM -1.41573510008399 0.0731105172007852 no 3134 0.0784265387638206 4360 16876704
SGTC_1904 st060225 78 µM -1.41698286001351 0.0729351555023415 no 3135 0.0782439693741491 4426 66595
SGTC_614 0462-0418 107 µM -1.4194667244382 0.0725870288008437 no 3136 0.0778814957146259 4219 5188303
SGTC_1700 st030840 7.9285 µM -1.42071875480326 0.0724120332788255 no 3137 0.0776992689915017 4486 5499307
SGTC_947 3447-0010 211 µM -1.42397748379109 0.0719580782540634 no 3138 0.0772264950494134 4408 748350
SGTC_2089 5281248 129.67 µM -1.42692676728743 0.0715491143665972 no 3139 0.0768005022271747 4436 2737878
SGTC_3090 9117696 49.47 µM -1.42880021643166 0.0712902593494019 no 3140 0.0765308316805963 4407 7923821
SGTC_1312 1218-2183 165 µM -1.43074421885241 0.0710224166280958 no 3141 0.0762517675639133 4502 6744073
SGTC_914 3820-6779 408 µM -1.43538007834287 0.0703868120765329 no 3142 0.0755894098620901 4389 2893481
SGTC_3084 9116877 49.47 µM -1.4367447820171 0.0702005386070315 no 3143 0.0753952626894886 4413 27241325
SGTC_517 1365-0151 113 µM -1.43787035518967 0.0700471904542786 no 3144 0.0752354211939539 4460 768657
SGTC_1609 st001574 46.4 µM -1.43977667434419 0.0697880614430524 no 3145 0.074965296253875 4447 3960012
SGTC_2964 9083345 53.42 µM -1.44166443486718 0.0695321828456432 no 3146 0.0746985306818543 4428 17741579
SGTC_1133 3473-0247 50 µM -1.44199130746145 0.0694879500050751 no 3147 0.0746524129211032 4430 711311
SGTC_325 2810-4341 181 µM -1.44380659856537 0.0692426965881207 no 3148 0.0743966926789823 4463 774970
SGTC_57 miconazole 162.5 nM -1.44415404406939 0.0691958313755159 no 3149 0.0743478243402144 4293 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2327 6189656 200 µM -1.44424026682677 0.0691842049983461 no 3150 0.0743357008743174 4525 5349088
SGTC_3278 9139605 49.47 µM -1.44462484676425 0.0691323661189813 no 3151 0.0742816448803275 4446 7958859
SGTC_56 0957-0365 83.25 µM -1.44587834495908 0.0689636104490676 no 3152 0.0741056633711722 4404 6752360
SGTC_1830 st055982 50.3 µM -1.44691667890791 0.0688240624571915 no 3153 0.0739601305887592 4469 455313 An antimicrobial agent.
SGTC_2130 NSC 7 2.4545 µM -1.44696509190929 0.0688175612564693 no 3154 0.0739533503595688 4511 21448
SGTC_1871 st057448 67.3 µM -1.44834113457437 0.0686329755520557 no 3155 0.0737608344476343 4458 691747
SGTC_3311 9131146 2.8755 µM -1.45793823432647 0.0673561983311562 no 3156 0.0724287843194303 4406 4900406 YPR165W RHO1
SGTC_1270 0831-1170 17.3 µM -1.45967136896736 0.0671275956679866 no 3157 0.0721902071397748 4486 6764716
SGTC_1379 2144-0755 36.5 µM -1.46157068442525 0.0668777630563437 no 3158 0.0719294463271923 4518 5392327
SGTC_1081 sertraline 6 µM -1.46213258599393 0.0668039895657653 no 3159 0.0718524403480582 4456 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1276 0871-0068 94.2 µM -1.4774323976948 0.0648193422798205 no 3160 0.0697798835406988 4501 3414906
SGTC_1289 0976-0073 69.1 µM -1.48016569095795 0.0644696571179683 no 3161 0.0694145170206911 4539 3391136
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.48367727050003 0.0640225546865926 no 3162 0.0689472795312777 4486 1377
SGTC_559 1550-0661 158 µM -1.48481118997167 0.0638786975321353 no 3163 0.0687969234234226 4522 5830875
SGTC_2746 daunorubicin 9.88 µM -1.49005763182253 0.0632163664636669 no 3164 0.0681045415268153 4506 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_696 1560-0013 611 µM -1.49055921519822 0.0631533257306191 no 3165 0.068038629447181 4520 1650269
SGTC_1926 methyl fluorone black 53.6 µM -1.49107050724387 0.0630891151753223 no 3166 0.0679714922698083 4124 72721 Reacts with homocysteine.
SGTC_1789 tunicamycin 25 nM -1.5005746484286 0.0619047730300987 no 3167 0.0667328062579664 4412 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.50607875940754 0.0612268645734174 no 3168 0.0660234782808844 4420 4000243
SGTC_1531 st059297 52.4 µM -1.51059818019214 0.0606745832522378 no 3169 0.0654454289562157 4536 7566702
SGTC_867 0518-0118 155 µM -1.51171737182429 0.0605384197907134 no 3170 0.0653028886844764 4492 6848158
SGTC_262 fenpropimorph 62.5 µM -1.51446650921108 0.0602049681694451 no 3171 0.0649537808951192 4525 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2060 5238662 140 µM -1.51751766148816 0.0598365694699204 no 3172 0.0645680189090132 4470 790130
SGTC_1457 k015-0032 57.3 µM -1.51840555107136 0.0597296972948852 no 3173 0.0644560965752073 4490 4302660
SGTC_1171 0368-0077 21.4 µM -1.52583753545983 0.0588409906331892 no 3174 0.0635251650907229 4490 3239779
SGTC_2844 9010103 25.97 µM -1.52761506405985 0.058629981506082 no 3175 0.0633040696876687 4474 2480525
SGTC_2888 9058547 12.99 µM -1.53118262373834 0.0582082720208104 no 3176 0.0628621320227032 4443 16476514
SGTC_1681 tripelennamine 100 µM -1.53434251253802 0.0578367453832755 no 3177 0.0624727061243717 4419 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2545 solidagenone 89.61 µM -1.54304512900756 0.0568231612270804 no 3178 0.0614099133147299 4456 6708572 An anti ulcer agent
SGTC_1403 3909-7815 62.9 µM -1.5457326981525 0.0565129863681342 no 3179 0.0610845684552249 4526 6615483
SGTC_1730 st033808 45.1 µM -1.54585004205625 0.0564994740580838 no 3180 0.0610703940915304 4440 1045166
SGTC_1557 sumaresinolic acid 42.3 µM -1.55616896691666 0.0553211596337126 no 3181 0.0598339593423632 4496 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2400 5203494 178.7 µM -1.56348914505227 0.0544971011331458 no 3182 0.058968793454362 4420 6777674
SGTC_2252 omeprazole 400 µM -1.5696725771534 0.0538086006841281 no 3183 0.0582456520820524 4564 4594 A proton pump inhibitor.
SGTC_2852 9023854 51.95 µM -1.5754783702439 0.0531684360731214 no 3184 0.0575730336305106 4534 19798528
SGTC_3292 9120825 59.784 µM -1.58016467183876 0.0526561265116617 no 3185 0.0570345799745759 4508 24824900
SGTC_1837 st055472 66.5 µM -1.58116504698012 0.0525472738513419 no 3186 0.0569201525036726 4574 676091
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.58256890273799 0.0523948189937637 no 3187 0.0567598780197639 4525 5377381
SGTC_1484 3473-2379 286 µM -1.58745028223194 0.0518674464607509 no 3188 0.0562053494071794 4644 671917
SGTC_527 4476-4215 268 µM -1.58993742332493 0.0516003686223921 no 3189 0.0559244555248495 4528 4418754
SGTC_903 1134-0042 114 µM -1.59361036159924 0.0512079567522791 no 3190 0.0555116661366386 4545 701009
SGTC_89 0302-0250 142.109 µM -1.60107652200097 0.0504176027438848 no 3191 0.054679985781566 4616 4203518 YLR208W SEC13
SGTC_1770 st043884 66.3 µM -1.60612355205109 0.0498888614735958 no 3192 0.0541233830059858 4558 670149
SGTC_292 k038-0015 474 µM -1.60690534803481 0.0498073553292308 no 3193 0.0540375665327273 4528 46368540
SGTC_2127 5253358 187.912 µM -1.61112387186938 0.0493693844928603 no 3194 0.0535763631232175 4479 20612
SGTC_475 α-linolenic acid 10 µM -1.62171880781819 0.0482829604460077 no 3195 0.0524317849258846 4549 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2944 9067346 25.62 µM -1.62412622587464 0.0480387856652142 no 3196 0.0521744359054282 4477 6473075
SGTC_911 3456-4043 236 µM -1.62928300815666 0.0475190796353756 no 3197 0.0516265607675109 4536 914281
SGTC_2543 pimpinellin 60.67 µM -1.63417066231972 0.0470306636472303 no 3198 0.0511115104316931 4434 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2107 5363541 170.161 µM -1.63669184270932 0.0467803041017608 no 3199 0.050847437136248 4500 244052
SGTC_604 1000-0114 314 µM -1.64207747297865 0.0462490787380983 no 3200 0.0502869747669515 4566 1572745
SGTC_557 1315-0110 16.2 µM -1.64559048429753 0.045905181997954 no 3201 0.0499240497886033 4550 6833801
SGTC_1264 0783-0040 158 µM -1.64952791142315 0.0455221834628968 no 3202 0.0495197649424568 4479 2855798
SGTC_834 0312-0008 75.7 µM -1.65171176893156 0.0453108671868928 no 3203 0.0492966611785064 4598 6385573 YIL048W NEO1
SGTC_2970 9090938 41.86 µM -1.65524160690558 0.0449709791538502 no 3204 0.0489377492487348 4599 17217104
SGTC_3083 9117465 49.47 µM -1.65850127694464 0.044658931087337 no 3205 0.0486081650005649 4533 16420915
SGTC_2834 9001755 58.44 µM -1.66113901193796 0.0444076994210929 no 3206 0.0483427654600955 4431 2989575
SGTC_1921 5740136 50 µM -1.66443826346943 0.0440950658856599 no 3207 0.0480124394244639 4508 1774243
SGTC_508 roscovitine 141 µM -1.66479288082793 0.0440615686068646 no 3208 0.0479770423802682 4632 160355 A CDKinase inhibitor.
SGTC_2581 avocatin a 64 µM -1.66952426301738 0.0436166007806432 no 3209 0.0475067630062029 4509 6710728 A skin care supplement.
SGTC_3068 9116768 49.47 µM -1.67180069335167 0.0434038073421498 no 3210 0.0472818150324451 4544 41904888
SGTC_2915 7971052 15.16 µM -1.67294073498668 0.0432975552974547 no 3211 0.047169481802203 4545 5741558
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.67301421147942 0.0432907144886412 no 3212 0.0471622491906426 4555 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1241 0364-0022 50.8 µM -1.67340270334178 0.0432545596224176 no 3213 0.0471240230179349 4583 4563895
SGTC_1313 1220-0047 237 µM -1.67592241074544 0.0430206554628786 no 3214 0.0468766956913215 4573 3528706
SGTC_2640 pentamidine 10.38 µM -1.67853483576625 0.0427792244242289 no 3215 0.0466213678808748 4530 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3165 9101544 49.47 µM -1.69050347343493 0.0416870922279314 no 3216 0.0454658371512655 4579 5002184
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.69770875512112 0.0410405776273916 no 3217 0.0447813722600452 4600 390807
SGTC_822 1487-0950 154 µM -1.71162341631135 0.0398150663126983 no 3218 0.0434830450733611 4582 1958375
SGTC_268 camptothecin 39.6153 µM -1.7126794077643 0.039723289181674 no 3219 0.0433857677699366 4550 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2176 5809774 33.9695 µM -1.71533986470095 0.0394928289805151 no 3220 0.0431414668632882 4528 2870539
SGTC_1041 0206-0046 107 µM -1.71593829205491 0.0394411407533005 no 3221 0.0430866686324423 4603 50494
SGTC_2743 auranofin 4.32 µM -1.71938432749809 0.0391445647903977 no 3222 0.0427722070398294 4657 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_232 clozapine 119 µM -1.72374807817154 0.0387716150092193 no 3223 0.0423766657652378 4645 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1195 1502-0147 41.1 µM -1.72753848212385 0.0384500202291465 no 3224 0.0420355001066075 4615 817940
SGTC_1769 st044406 64.4 µM -1.73047068653323 0.0382027333125571 no 3225 0.0417731070670944 4579 670903
SGTC_2600 tangeritin 87.95 µM -1.73273326371678 0.0380128070793547 no 3226 0.0415715446728712 4524 68077 A bioactive flavone.
SGTC_385 1494-0393 12.4 µM -1.73713261410159 0.0376457200060767 no 3227 0.0411818829031769 4561 3090647
SGTC_250 brefeldin a 552.239 µM -1.7420437199656 0.0372393554053094 no 3228 0.0407503971772411 4566 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1348 1493-0373 93.8 µM -1.74646518581494 0.0368765780666075 no 3229 0.0403650757382333 4616 3010129
SGTC_974 1326-0144 138 µM -1.75154267195755 0.0364635447361529 no 3230 0.0399262388148037 4618 5411856
SGTC_1485 3909-9022 254 µM -1.75561680422343 0.0361348744219019 no 3231 0.0395769304792595 4667 714516
SGTC_509 pifithrin 175 µM -1.75582138911091 0.0361184342286352 no 3232 0.0395594555072863 4685 4817 A p53 inhibitor.
SGTC_2129 girgensonine 121.053 µM -1.75669021652949 0.0360486845364841 no 3233 0.0394853130146588 4589 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_552 k242-0005 476 µM -1.75682447860977 0.0360379157888535 no 3234 0.0394738656791983 4654 4088318
SGTC_3052 9092717 49.47 µM -1.75989644641942 0.0357922416554079 no 3235 0.0392126829832735 4606 25237534
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.75992705938232 0.0357898003717473 no 3236 0.0392100873245667 4682 688801
SGTC_2192 5915882 198.485 µM -1.76559600737567 0.0353400668459716 no 3237 0.0387318251726055 4627 2876149
SGTC_2654 protoveratrine a 100 µM -1.76581876660855 0.0353224898085347 no 3238 0.0387131295072473 4630 5702278 A heart drug and vasodilator.
SGTC_324 1315-0088 19.6 µM -1.76802091099445 0.0351491129504968 no 3239 0.0385287039455065 4601 6787421
SGTC_98 0074-0023 107.663 µM -1.77052370234999 0.0349529142353088 no 3240 0.0383199697385795 4610 3563821
SGTC_2218 6965428 192.983 µM -1.77638429288593 0.0344970064326558 no 3241 0.0378347991066775 4533 675684
SGTC_3354 9151612 71.43 µM -1.78132698626141 0.0341163118046773 no 3242 0.0374295241849041 4603 27261949
SGTC_3004 9076122 71.4286 µM -1.78287538296163 0.0339977646400843 no 3243 0.0373032955714182 4609 44782551
SGTC_651 3253-0966 34.4 µM -1.78460263860466 0.0338659237509128 no 3244 0.0371628965666347 4634 781462
SGTC_1003 4049-0218 100 µM -1.78639139135079 0.0337298324030832 no 3245 0.0370179542525534 4624 295161
SGTC_300 r073-0011 5.04 µM -1.79271023348804 0.0332526822186695 no 3246 0.0365096346746803 4626 2735780
SGTC_1458 k015-0034 6.33 µM -1.79856690745109 0.0328154092563074 no 3247 0.0360436080130797 4639 3598957
SGTC_1121 fusaric acid 630.51 nM -1.80854014426803 0.0320816987933626 no 3248 0.0352612373602595 4603 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.81507480336351 0.0316083420972717 no 3249 0.0347562073641171 4580 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_387 norethindrone acetate 66.7 µM -1.81770447199265 0.0314194903441441 no 3250 0.0345546569403574 4632 541197
SGTC_2713 st079149 53.4 µM -1.82087139957848 0.031193294141539 no 3251 0.0343132038246349 4652 3103253
SGTC_2374 9071832 200 µM -1.8212270531145 0.0311679761075447 no 3252 0.034286174878247 4587 17381698
SGTC_1027 k015-0025 8.67 µM -1.82743817322781 0.0307285567390394 no 3253 0.0338169571037637 4615 3598955
SGTC_1107 amlodipine 47 µM -1.84366682376329 0.029604584720114 no 3254 0.0326158554143357 4206 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1629 st005085 44.9 µM -1.84568929835294 0.0294669329373004 no 3255 0.032468665985776 4606 24207091
SGTC_3107 9121808 49.47 µM -1.84972468870637 0.0291938675297693 no 3256 0.0321766201225821 4602 662681
SGTC_2361 9034121 116 µM -1.85364124917024 0.0289308563895901 no 3257 0.0318952510521957 4661 6496917
SGTC_2871 9038510 12.99 µM -1.85985007010778 0.0285179492358747 no 3258 0.0314533705592765 4600 4945164
SGTC_1492 4158-0558 28.5 µM -1.86282445345922 0.0283218864958003 no 3259 0.0312434842092416 4651 3967268
SGTC_2008 4012253 172 µM -1.88000944244547 0.0272109461671839 no 3260 0.0300533955250036 4634 603940
SGTC_1314 1222-0010 41.1 µM -1.88200920995475 0.0270840632495621 no 3261 0.0299173825814323 4655 3526027
SGTC_672 1441-0018 53.7 µM -1.90213732805001 0.0258342365353989 no 3262 0.0285766017730034 4670 251141
SGTC_2807 7945238 51.95 µM -1.9074077454577 0.0255150690675417 no 3263 0.0282339035844377 4631 17148797
SGTC_2676 harmalol 100 µM -1.91497901906912 0.0250623498002925 no 3264 0.0277475896809683 4655 5459187 A monoamine oxidase inhibitor
SGTC_61 0978-8327 98.565 µM -1.91703286078514 0.0249407092253634 no 3265 0.0276168785368934 4608 6150059 YHR072W ERG7
SGTC_741 4582-0002 126 µM -1.9214276119172 0.0246820885475284 no 3266 0.0273389101309663 4677 2912688
SGTC_2748 diazoxide 86.69 µM -1.92484184045238 0.0244827256060198 no 3267 0.0271245738835252 4735 3019 A potassium channel activatior.
SGTC_927 2425-1185 123 µM -1.92649337039231 0.0243867758928033 no 3268 0.027021399429397 4632 730375
SGTC_2474 5321570 43.32 µM -1.92984282864967 0.0241931500308678 no 3269 0.0268131575002356 4671 2841384
SGTC_848 0368-0089 85.6 µM -1.9406590376318 0.0235766814818303 no 3270 0.0261498239998053 4671 762535
SGTC_2094 5332512 191.667 µM -1.95687384514195 0.022677304591003 no 3271 0.0251811511477901 4694 755774
SGTC_1493 4348-0038 111 µM -1.9626115737176 0.0223660592974298 no 3272 0.0248456624352345 4684 800424
SGTC_825 1988-2224 89.6 µM -1.96312377148971 0.0223384509646751 no 3273 0.0248158970076447 4670 1180859
SGTC_2868 9035608 32.47 µM -1.97294043958898 0.0218148459959672 no 3274 0.0242511742787532 4665 6462614
SGTC_2669 eugenol 100 µM -2.00021490901001 0.020414192023954 no 3275 0.0227385312963689 4714 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2638 epoxomicin 18 µM -2.00179161795342 0.0203356069105098 no 3276 0.022653573913377 4662 9915668 A protesome inhibitor.
SGTC_3200 9114385 49.47 µM -2.00283820799749 0.0202835852934145 no 3277 0.0225973286584866 4651 17018030 YLR208W SEC13
SGTC_2345 9052315 157.45 µM -2.00571749527519 0.0201410497439762 no 3278 0.0224431987628259 4673 6469265
SGTC_2002 4023503 131 µM -2.00836896627914 0.0200105441125893 no 3279 0.0223020490740831 4673 4736863 YCR052W RSC6
SGTC_270 tamoxifen 5.46 µM -2.01132562468053 0.0198658637871867 no 3280 0.0221455367915573 4687 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1126 isoteolin 1.0172 µM -2.01528182216805 0.0196736616704632 no 3281 0.0219375642354551 4640 133323
SGTC_2650 prasterone 100 µM -2.01531646031096 0.0196719858584095 no 3282 0.0219357506575746 4717 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2105 5350118 200 µM -2.01837819964305 0.0195243353107925 no 3283 0.0217759440260401 4671 2133313
SGTC_777 1315-0167 517 µM -2.02068794126839 0.0194135732258847 no 3284 0.021656039454825 4700 4221767
SGTC_2648 atorvastatin 78.68 µM -2.02720687272143 0.0191038378464148 no 3285 0.0213206302979944 4706 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1812 st052057 4.327 µM -2.02959008364596 0.0189916574846854 no 3286 0.0211991118610043 4719 3645418
SGTC_2207 7258803 200 µM -2.03561721335067 0.0187104511886992 no 3287 0.02089440396963 4708 3666799
SGTC_3277 9138724 49.47 µM -2.05046546477776 0.0180327603035598 no 3288 0.0201595152724277 4700 15943418
SGTC_3188 9110789 49.47 µM -2.06190132072936 0.0175251840811886 no 3289 0.0196085658895934 4670 849217
SGTC_2066 5222451 176 µM -2.06734449986591 0.0172879068112211 no 3290 0.0193508519565861 4645 2281147
SGTC_1042 0350-0096 82 µM -2.07135511205856 0.0171148383112345 no 3291 0.0191628112371763 4688 3122515
SGTC_3058 9093861 49.47 µM -2.11183828711462 0.0154492425482176 no 3292 0.017350161046703 4713 17217477
SGTC_269 exalamide 29 µM -2.11501387706763 0.015324685688388 no 3293 0.017214382296102 4720 3316 A derivative of salicylamide.
SGTC_1903 st060211 78.3 µM -2.12384531461668 0.0149828128566529 no 3294 0.0168415402011252 4711 688960
SGTC_2935 9038016 29.96 µM -2.13820145182671 0.0144410637222871 no 3295 0.0162501983037959 4665 6463195
SGTC_1726 st035556 14.5795 µM -2.14311837012173 0.0142594349665738 no 3296 0.0160517973705486 4706 5919439
SGTC_1943 st076331 65.2 µM -2.14330350562727 0.0142526347567923 no 3297 0.0160443677638047 4691 24208415
SGTC_1799 st045822 46.1415 µM -2.1461572524497 0.0141481666800339 no 3298 0.0159302173984851 4705 3674992
SGTC_1675 st018485 24.5 µM -2.15319965003783 0.013893182227588 no 3299 0.0156514955890739 4706 3323024
SGTC_2376 9072922 81.32 µM -2.15504268690865 0.0138271091355918 no 3300 0.0155792469896899 4703 17087968
SGTC_2740 felodipine 17.08 µM -2.16147864111362 0.0135985005570853 no 3301 0.0153291925567345 4760 3333 L-type calcium channel blocker
SGTC_3253 9135987 49.47 µM -2.17336336826971 0.0131849136285406 no 3302 0.0148764897993701 4719 4182430
SGTC_2022 5136654 200 µM -2.18694931691891 0.0127254803490599 no 3303 0.0143731120699876 4692 1713771
SGTC_1323 1348-1351 11.2 µM -2.21467223606934 0.0118307897981721 no 3304 0.0133912849327118 4718 6989654
SGTC_2262 9014885 67.46 µM -2.2605225840928 0.0104706590289435 no 3305 0.011894418197713 4758 6457424
SGTC_1158 4092-0494 91.8 µM -2.26731472041085 0.0102812278656987 no 3306 0.0116855034291881 4768 1148199
SGTC_830 4076-0286 57.8 µM -2.28028335185597 0.00992782301923245 no 3307 0.01129544427067 4759 6866659
SGTC_1028 k015-0029 4.8 µM -2.28262767399508 0.0098650831177539 no 3308 0.011226154701793 4731 4588309
SGTC_1007 4101-0031 70 µM -2.31322103109111 0.00907752502511204 no 3309 0.0103552449186513 4726 1146276
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -2.32138221900465 0.00887696747474137 no 3310 0.0101331121637172 4762 66535 A nucleotide analog.
SGTC_1550 gossypolone 36.6 µM -2.33093167023438 0.00864723298762112 no 3311 0.00987848149673769 4755 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_38 0929-0051 58.268 µM -2.34232812604283 0.00837990281827277 no 3312 0.00958192917923555 4721 1379719
SGTC_1161 k007-0610 110 µM -2.34766983216971 0.00825711778242268 no 3313 0.00944562934942753 4682 5843850
SGTC_2572 astragaloside iv 100 µM -2.3528389260374 0.00813980770735696 no 3314 0.00931535125356134 4714 45006101 An anti-inflammatory agent.
SGTC_433 pimozide 108 µM -2.37596288806853 0.00763276671661549 no 3315 0.00875161157239107 4704 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1573 oleylamine 1.06 µM -2.37813410753119 0.00758661757658306 no 3316 0.00870024812121884 4738 5356789 An amine of the fatty acid oleic acid.
SGTC_2311 7694451 200 µM -2.41004825960447 0.00693608561592921 no 3317 0.00797520525291445 4741 2163142
SGTC_3325 9138760 55.175 µM -2.42023277481714 0.00673911587563409 no 3318 0.00775528736848403 4720 43844959
SGTC_2015 5119600 184 µM -2.43627959847656 0.00643878989716065 no 3319 0.0074196047410614 4720 2828786
SGTC_2936 9038235 15.59 µM -2.44434204088019 0.00629241428038525 no 3320 0.0072558306054897 4710 4749415
SGTC_1373 2887-0003 58.5 µM -2.45000990929661 0.00619128386931059 no 3321 0.00714261416342893 4731 776948
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -2.4637634080531 0.0059518454338242 no 3322 0.0068743415550042 4751 229346 A bile salt which induces apoptosis.
SGTC_429 1112-0049 25.5 µM -2.48222338436284 0.00564339020272111 no 3323 0.00652826979344177 4727 2836170
SGTC_1242 0402-0103 60.1 µM -2.48286059321599 0.00563300102945827 no 3324 0.0065166041080167 4711 432868
SGTC_2025 5147754 141 µM -2.48339454918355 0.00562430839277119 no 3325 0.00650684292466089 4755 315777 YLR208W SEC13
SGTC_2323 6148992 148.28 µM -2.48648170427889 0.00557428361008255 no 3326 0.00645066015952865 4729 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2118 5526350 200 µM -2.50691715823273 0.00525299626279752 no 3327 0.00608946258262768 4756 743594
SGTC_3155 9099265 49.47 µM -2.50789143599463 0.00523809857509878 no 3328 0.00607269881345424 4745 25236499
SGTC_3056 9094900 49.47 µM -2.51354400036342 0.00515240453159705 no 3329 0.00597624334941946 4755 25236784
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -2.51703457058031 0.00510011203822746 no 3330 0.00591736081814082 4754 3256 An antibiotic and ribosome inhibitor.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -2.5202037058919 0.00505304475491089 no 3331 0.00586434678904517 4769 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2032 5185112 25.99 µM -2.52910092033326 0.00492296594687969 no 3332 0.00571775701056852 4725 5718189
SGTC_3154 9100113 49.47 µM -2.55655960277878 0.00454012538044232 no 3333 0.00528564795496011 4746 25237525
SGTC_3203 9113543 49.47 µM -2.57165550777289 0.00434117656000284 no 3334 0.005060677425286 4743 17018012
SGTC_1985 st071382 65.5 µM -2.59970918416996 0.00399204698115483 no 3335 0.0046651396599047 4771 6123237
SGTC_1488 4013-0813 75.9 µM -2.61716681814793 0.00378768911719096 no 3336 0.00443314993687352 4781 2910057
SGTC_2576 guaiol 23.12 µM -2.62008832236283 0.00375442156468303 no 3337 0.0043953498168188 4730 227829
SGTC_179 1273-0063 6.77 µM -2.62515204809741 0.00369738041933911 no 3338 0.00433051406145807 4743 3108139
SGTC_438 sphingosine 6.67 µM -2.62584525826879 0.00368963243887978 no 3339 0.00432170506761957 4738 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1987 st072290 61.9 µM -2.68502011173428 0.00307955650298637 no 3340 0.0036262720952346 4781 54697379
SGTC_3185 9108267 49.47 µM -2.73288272392649 0.00265428461388524 no 3341 0.00313913413131537 4782 4910486
SGTC_1149 3909-7961 23.3 µM -2.74147862858397 0.00258378593603896 no 3342 0.00305816697513222 4789 735261
SGTC_2937 9044753 11.33 µM -2.81616499762689 0.00203890895879162 no 3343 0.00243003497199186 4757 6465530 YGL099W LSG1
SGTC_35 0133-0054 64.071 µM -2.89317158415844 0.00158830464019347 no 3344 0.00190686446406772 4754 99677
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -2.90049545603786 0.001550566655317 no 3345 0.00186286620011374 4781 803109
SGTC_958 1222-0007 33 µM -2.9210732037447 0.00144886887627413 no 3346 0.00174413926906668 4790 7312461
SGTC_879 0831-1030 162 µM -2.93165479335841 0.00139897853505041 no 3347 0.00168580646751939 4786 1549252
SGTC_3002 9075603 71.4286 µM -3.00386680587168 0.00109829532699312 no 3348 0.00133285999200474 4785 20105405
SGTC_390 dec-rvkr-cmk 16.7 µM -3.01951726341556 0.00104149518396246 no 3349 0.00126588931927406 4797 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2536 dehydroabietamide 32.04 µM -3.08222473549326 0.000839909898330454 yes 3350 0.00102729828032838 4788 3983547
SGTC_1907 st060210 83.7 µM -3.09986377392039 0.000790056797920132 yes 3351 0.00096804833315044 4790 688793
SGTC_2384 9036245 200 µM -3.20081520329834 0.000553442355407902 yes 3352 0.000685196954340255 4800 6462766
SGTC_386 1509-0011 3.07 µM -3.65382282952163 9.92629774666609e-05 yes 3353 0.000129182289853957 4802 3107280
SGTC_1836 st055642 81 µM -3.72297261768983 7.50345823653848e-05 yes 3354 9.84454412616278e-05 4805 8571
SGTC_3157 9099274 49.47 µM -3.76543686397774 6.30420753429299e-05 yes 3355 8.31290661766566e-05 4803 17217662
SGTC_2533 agelasine 13.65 µM -4.17467157857436 1.07523769927334e-05 yes 3356 1.49208120322294e-05 4806 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.