SGTCid condition conc unit YLR278C|YLR278C.score YLR278C|YLR278C.strain.pval YLR278C|YLR278C.strain.significant YLR278C|YLR278C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1134 3477-0009 42.5 µM 8.4148338573659 5.5608286443727e-16 yes 1 1.96726078176622e-17 2 3973534 SGTC_1712 st032288 53.4 µM 7.10834370272399 6.51356495127711e-12 yes 2 5.87218977612799e-13 53 2883011 SGTC_1046 2001-0062 216 µM 5.07562030400284 6.80743382325087e-07 yes 3 1.93116944189275e-07 4 739778 SGTC_1187 1391-0724 117 µM 4.84274817629188 2.02727261991095e-06 yes 4 6.40277701950302e-07 7 6997986 SGTC_3109 9122853 49.47 µM 4.71965109338923 3.54082872195739e-06 yes 5 1.18124755820077e-06 1 1234709 SGTC_2364 9055074 200 µM 4.70288354864149 3.81636566232617e-06 yes 6 1.28256368376394e-06 10 6470630 SGTC_920 mycophenolic acid 780.421 nM 4.64653816105713 4.90041562014972e-06 yes 7 1.68775856885432e-06 13 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_915 methyl methanesulfonate (MMS) 110 mM 4.32566842620902 1.93053689002952e-05 yes 8 7.60350114443624e-06 34 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1109 tnp00067 928.257 nM 4.31219895064533 2.04090756172755e-05 yes 9 8.08194430724144e-06 7 676295 SGTC_2536 dehydroabietamide 32.04 µM 4.14952844447873 3.94483525675973e-05 yes 10 1.66580444187534e-05 29 3983547 SGTC_1465 k213-0056 144 µM 3.91054133148841 9.96496949833128e-05 yes 11 4.60447499128293e-05 23 24048857 YMR208W ERG12 SGTC_1733 st037357 54.9 µM 3.82966184301094 0.00013484352651832 yes 12 6.41597340778248e-05 34 1272339 YGL099W LSG1 SGTC_2173 5763948 167 µM 3.76890789577566 0.000168613305059807 yes 13 8.19816858167612e-05 17 2867177 SGTC_1778 st046819 58.9 µM 3.68218968531574 0.000230701400816306 yes 14 0.000115619625825686 33 671715 SGTC_2750 bromebric acid 70.15 µM 3.6320164566335 0.000275771782706996 yes 15 0.000140607591651918 42 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_514 4466-0038 2.65 nM 3.60525768895155 0.000303039863395451 yes 16 0.000155921670534186 174 5722064 SGTC_445 e6 berbamine 66 µM 3.58147161234832 0.00032936476323459 yes 17 0.000170832133497738 136 6610268 A calcium/calmodulin antagonist. SGTC_3059 1327-0034 3 µM 3.45745260746721 0.000504548926925859 yes 18 0.000272654073558209 70 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1368 1852-0141 284 µM 3.44371759831913 0.000528526132138234 yes 19 0.000286887336457713 55 2838987 SGTC_775 4577-0580 57.3 µM 3.43719752180439 0.000540273409536047 yes 20 0.000293883402106342 15 2006902 SGTC_3192 9110362 49.47 µM 3.38818359851917 0.000636619290572324 yes 21 0.000351785757039911 21 16649480 SGTC_3026 9090633 49.47 µM 3.29535651202137 0.000863812322158668 yes 22 0.000491484439997454 44 25236842 SGTC_777 1315-0167 517 µM 3.2516483722821 0.000994778902491777 yes 23 0.000573689360279055 51 4221767 SGTC_1898 st060199 18.6 µM 3.2174067899213 0.0011098503101687 no 24 0.000646775253059832 32 688866 SGTC_3113 9123498 49.47 µM 3.19428291660944 0.00119432809338126 no 25 0.000700893335944194 32 8897275 SGTC_6 0844-0013 19.835 µM 3.18895146240532 0.00121462235204395 no 26 0.000713949253953216 175 1584900 SGTC_58 0957-0393 9 µM 3.11776773624212 0.00151755436164539 no 27 0.000911131745712515 477 6997992 SGTC_1688 st021091 57.6 µM 3.09181796274534 0.00164412571281891 no 28 0.000994674013156784 19 3656366 SGTC_2570 licareol 100 µM 2.99299679269028 0.00221906141483157 no 29 0.00138126326188458 72 443158 SGTC_55 0767-0285 6.563 µM 2.98418651797835 0.00227827972379047 no 30 0.00142166694626531 90 3116166 SGTC_1448 4255-0083 152 µM 2.97515988664871 0.00234043340862252 no 31 0.00146417937785823 61 5399660 SGTC_3319 9138450 16.7555 µM 2.97220007581371 0.00236114520687072 no 32 0.00147836967813861 58 2029690 SGTC_1038 k292-0204 154 µM 2.9666980807206 0.00240008776639587 no 33 0.00150508196022343 49 4454212 SGTC_2773 thioridazine 9.09 µM 2.95357606780941 0.0024953204984489 no 34 0.00157057591739447 48 5452 An antipsychotic. SGTC_2694 st077685 81.9 µM 2.94312824811575 0.00257357438245316 no 35 0.00162456893987449 82 2838096 SGTC_2150 5556613 200 µM 2.93230707216591 0.00265695644411065 no 36 0.00168226947216841 62 743190 SGTC_2062 5245942 200 µM 2.88489426905505 0.00305179714243821 no 37 0.00195772568398402 66 1376160 SGTC_537 1334-0398 209 µM 2.88386598840531 0.00306091726006461 no 38 0.00196412941530968 76 5846986 SGTC_1646 st011709 75.6 µM 2.86742052033964 0.00321015052490827 no 39 0.0020691636707249 49 5757843 SGTC_2661 dactinomycin 12.96 µM 2.86182521898046 0.00326239789333213 no 40 0.00210604558326213 78 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_677 0929-0063 136 µM 2.82782079787659 0.00359669731564144 no 41 0.00234330165069131 52 1539583 SGTC_860 0443-0016 25.1 µM 2.82406951022882 0.00363539854962673 no 42 0.00237090499645907 86 5337942 SGTC_1883 5-benzylidenerhodanine 20 µM 2.82179323893852 0.00365906412835973 no 43 0.00238779777428081 160 1273210 SGTC_2906 7926292 26.41 µM 2.78239769291814 0.00409113456676466 no 44 0.00269794373137229 99 2966319 SGTC_1147 3809-1045 12.3 µM 2.73188277812895 0.0047116985584958 no 45 0.0031486771042203 106 325925 SGTC_348 k064-0012 10.7 µM 2.71740445915833 0.00490440866555553 no 46 0.00328980742342661 79 5066323 SGTC_971 1315-0384 26.7 µM 2.70366878321967 0.00509369449739682 no 47 0.00342893047208349 99 6769120 SGTC_2385 9074692 200 µM 2.68859974334958 0.00530881194588118 no 48 0.00358761979966278 113 17046906 SGTC_918 glabranin 770.725 nM 2.68551264001959 0.00535386610573794 no 49 0.00362093177475582 108 124049 Also referred to as licorice root. SGTC_906 1165-0455 526 µM 2.67733933661885 0.00547479567552427 no 50 0.00371047168676472 57 3252859 SGTC_1293 1000-1278 195 µM 2.67287835824985 0.00554181766553834 no 51 0.00376017573010774 86 678847 SGTC_2553 4-methylesculetin 85.09 µM 2.66709050851245 0.00562986046351443 no 52 0.00382555320055091 101 5319502 SGTC_2369 9071472 200 µM 2.65461496807721 0.00582386987562655 no 53 0.00396994890657124 90 17296037 SGTC_2029 5175081 200 µM 2.64958407034475 0.00590376965723264 no 54 0.00402954592953998 107 1380876 SGTC_574 1315-0397 40 µM 2.6484385878261 0.00592209730794378 no 55 0.00404322699133598 141 6794277 SGTC_2459 5811157 9.22 µM 2.63707632858759 0.0061066430978285 no 56 0.00418120063984703 75 2870684 YBR192W RIM2 SGTC_539 4859-0462 2.54 µM 2.61289463822275 0.0065164511783306 no 57 0.00448894874721725 105 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_853 0419-0306 21 µM 2.59505224137138 0.00683423786485139 no 58 0.00472882712964605 76 762713 SGTC_1864 st057645 30.4 µM 2.58425284789258 0.00703316531785572 no 59 0.00487951103447116 72 688666 SGTC_2649 anisomycin 9.56 µM 2.57634501231604 0.00718205350277026 no 60 0.0049925479347555 58 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_135 0933-0004 26.348 µM 2.52676063838453 0.00818057069009244 no 61 0.0057559966391883 117 21230617 YGL099W LSG1 SGTC_92 0063-0024 660.874 µM 2.52311828106149 0.00825851236215827 no 62 0.00581596344470707 89 3594437 SGTC_1202 1988-0068 29.6 µM 2.52002111061064 0.00832530008706796 no 63 0.00586738980868503 131 2850480 SGTC_2597 laccaic acid a 100 µM 2.51666394294975 0.00839822965329815 no 64 0.00592358843836941 142 5491415 A textile dye. SGTC_1119 parthenolide 318.541 nM 2.51203515446841 0.00849970278527142 no 65 0.00600185651680722 171 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3102 9121669 49.47 µM 2.50765500633871 0.00859671433160932 no 66 0.00607676314358701 69 41905072 SGTC_1674 st016616 23.6 µM 2.48683645380469 0.00907120116713098 no 67 0.00644423168809645 135 625830 SGTC_2470 5664817 21.68 µM 2.48374552849691 0.00914356884623545 no 68 0.00650043376150293 92 2859561 SGTC_1667 st014849 34.6 µM 2.47194055226251 0.00942463003077815 no 69 0.00671909303300725 79 5348460 SGTC_2754 granisetron 64.02 µM 2.46690809692953 0.0095467251449582 no 70 0.00681426656527374 153 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2068 5226020 147 µM 2.46479625819426 0.0095983720962683 no 71 0.00685455897937722 155 1810509 SGTC_2248 tofa 1.1 µM 2.46007758691732 0.00971465479748027 no 72 0.00694534913809343 127 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1016 4226-1401 38 µM 2.45864406394458 0.00975022415649682 no 73 0.00697314047569455 125 2901613 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 2.44637842788769 0.0100592457556431 no 74 0.00721497265490369 332 16725076 SGTC_1505 k297-0037 20.6 µM 2.43856088889194 0.010260631531775 no 75 0.00737293713098884 124 4089396 SGTC_976 1348-1067 47.6 µM 2.43801448119802 0.0102748379695466 no 76 0.00738409119035163 145 5310671 YGL099W LSG1 SGTC_3043 9092303 49.47 µM 2.43727943388281 0.0102939760373096 no 77 0.00739911949057087 114 25236084 SGTC_25 0118-0223 35.662 µM 2.43109436908279 0.0104562484742384 no 78 0.00752664662276723 120 5333628 SGTC_2639 lactacystin 53 µM 2.42711937789013 0.010561709886604 no 79 0.00760962353498904 136 3870 A proteasome inhibitor. SGTC_320 4092-0846 5.34 µM 2.40698886815672 0.0111101459269084 no 80 0.00804233006844993 151 1359356 SGTC_2116 5511452 16.8835 µM 2.40367785332958 0.0112026838419891 no 81 0.00811553475042437 116 870744 SGTC_3122 9126309 49.47 µM 2.40126827558343 0.0112704485274235 no 82 0.00816917667893184 96 17591206 SGTC_1951 sophoraflavanone G 9.2 µM 2.38466876998159 0.0117470319844253 no 83 0.00854725249355511 149 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2449 5812982 45.77 µM 2.3628104287577 0.0124012133807932 no 84 0.00906847225632379 102 776185 SGTC_1970 st070122 35.8 µM 2.3552560918644 0.0126345244398046 no 85 0.00925497211107881 156 102928 SGTC_315 k915-0449 187 µM 2.35455834361423 0.0126562643885735 no 86 0.00927236612155616 195 20970215 YNL149C PGA2 SGTC_2165 5727197 32.143 µM 2.34584144011842 0.0129305999259758 no 87 0.00949209081565798 178 1361712 SGTC_2404 5161160 200 µM 2.34538398067594 0.0129451378709511 no 88 0.009503746572913 143 2831543 SGTC_1025 k007-0731 70 µM 2.33491210377614 0.0132818176142959 no 89 0.00977400646035544 130 6256118 SGTC_1074 carmofur 3.8 µM 2.32380037219359 0.0136473143893672 no 90 0.0100680978954884 178 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2936 9038235 15.59 µM 2.29528486781472 0.0146252229105377 no 91 0.010858402122376 159 4749415 SGTC_1741 st038134 10.228 µM 2.29300436448605 0.0147059715086002 no 92 0.0109238768405762 192 1272587 SGTC_2811 7967822 32.47 µM 2.28305851713555 0.0150626355265518 no 93 0.0112134608307682 137 2232244 SGTC_2600 tangeritin 87.95 µM 2.28047300123063 0.0151565621382896 no 94 0.0112898251447033 149 68077 A bioactive flavone. SGTC_521 r062-0005 13.8 µM 2.26487751984157 0.0157338527986156 no 95 0.0117600983209163 135 2832033 SGTC_952 1185-0122 232 µM 2.26014367628501 0.0159127731144262 no 96 0.0119061675896114 161 678600 SGTC_3298 9116858 71.43 µM 2.25818398640248 0.0159873505107997 no 97 0.011967095601333 143 2506942 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 2.2561040998032 0.016066829616098 no 98 0.0120320562213775 171 688664 SGTC_1114 scopoletin 1.73284 µM 2.25089919393547 0.0162672111200244 no 99 0.0121959614079528 136 5280460 A coumarin with genotoxic properties. SGTC_2900 5328528 85.29 µM 2.24944307585151 0.016323651355002 no 100 0.0122421603124072 191 795359 SGTC_1339 1486-1321 22.7 µM 2.24844017935728 0.0163626218392174 no 101 0.0122740677776038 162 3469382 SGTC_1052 3253-3998 198 µM 2.24690501316997 0.016422429530131 no 102 0.0123230491335204 186 5450317 SGTC_560 2332-1943 155 µM 2.23896883584004 0.016734604032485 no 103 0.0125789719791226 115 21177716 SGTC_1513 0337-0559 19 µM 2.23009329269287 0.0170897290062031 no 104 0.0128706250104692 172 775073 SGTC_2038 4100038 30.985 µM 2.22988079140076 0.0170983098820658 no 105 0.0128776789653765 180 3596803 SGTC_1708 st033234 31.827 µM 2.22964484182452 0.0171078419216874 no 106 0.0128855152003734 146 674664 SGTC_1972 st070201 17.4 µM 2.203128583822 0.0182083932536411 no 107 0.0137928435308313 154 2829099 SGTC_3290 9121031 71.43 µM 2.19533407214485 0.0185431601270988 no 108 0.0140698212580426 134 17014854 SGTC_604 1000-0114 314 µM 2.18722139864804 0.0188971432418098 no 109 0.014363182742075 177 1572745 SGTC_2419 paclitaxel 166.5 µM 2.18657075115238 0.0189257805287692 no 110 0.0143869372501591 249 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_124 0136-0217 7.121 µM 2.18416257330315 0.0190320942907967 no 111 0.0144751520119585 216 3976905 SGTC_123 0083-0120 66.675 µM 2.18002269920471 0.0192160442062486 no 112 0.0146278894982178 205 16001701 SGTC_2735 sertaconazole 140 nM 2.16636953561462 0.0198334512206538 no 113 0.0151414799890862 103 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3120 9124077 49.47 µM 2.1516202250059 0.0205192632533823 no 114 0.015713638933962 142 18774327 YGL155W CDC43 SGTC_3121 9125696 49.47 µM 2.1516170967768 0.020519410814041 no 115 0.0157137622255737 102 1235365 SGTC_1150 3909-7983 10.9 µM 2.14828122785483 0.0206772784958746 no 116 0.0158457106228977 204 23965914 SGTC_2146 5545642 200 µM 2.13462713770162 0.0213342127753522 no 117 0.0163957394630811 137 825326 SGTC_1763 st044482 94.5 µM 2.12668712686276 0.0217242809440963 no 118 0.0167230439127777 192 88505 SGTC_1199 1638-0010 4.46 µM 2.12123520108741 0.0219955919229943 no 119 0.0169510071739646 213 3111136 SGTC_2468 5987765 72.9 µM 2.11521799098628 0.0222983491919384 no 120 0.0172056861319325 157 26772094 SGTC_3115 9123671 49.47 µM 2.10902362577475 0.022613684954378 no 121 0.017471271192061 127 3286988 SGTC_1386 3228-0095 33.8 µM 2.09063794887526 0.0235718606129406 no 122 0.0182802656185527 168 870181 SGTC_2465 5809242 33.21 µM 2.09022844147463 0.0235935851454233 no 123 0.0182986419039103 101 2731748 SGTC_2267 7931562 200 µM 2.07093681204657 0.0246362643238674 no 124 0.0191823507282285 178 934880 SGTC_1185 1319-0113 81.3 µM 2.06205152327622 0.0251293498255234 no 125 0.0196014154575321 168 4672763 SGTC_225 nsc-122657 1.016 µM 2.05593250941495 0.0254737099936389 no 126 0.0198945110141616 110 275685 SGTC_2833 9001315 45.46 µM 2.04921953042308 0.0258560340024309 no 127 0.0202203265680222 257 2989378 SGTC_147 4466-0538 29.23 µM 2.04469500649145 0.0261164183934729 no 128 0.0204424681200607 227 6742687 YHR072W ERG7 SGTC_1676 st018489 23.4 µM 2.04114075249359 0.0263224988985515 no 129 0.0206184193546359 250 3696235 SGTC_3053 9095903 49.47 µM 2.02567718132618 0.027234984423578 no 130 0.0213989382704224 147 17174018 SGTC_1421 4029-0249 71.4 µM 2.02275795932221 0.0274101715845444 no 131 0.0215490540114468 238 2894095 SGTC_1744 st037937 38.9 µM 2.02063421769505 0.0275382103499881 no 132 0.0216588220326004 216 1016152 SGTC_2556 citropten 84.59 µM 2.01723051884454 0.0277444564682443 no 133 0.0218357313047318 249 2775 A potential DNA crosslinker. SGTC_3163 9099914 49.47 µM 2.01293934847325 0.0280063114047631 no 134 0.0220605051936193 114 16268368 SGTC_1297 1068-0111 14.1 µM 2.01024631312041 0.0281716940303589 no 135 0.0222025629555922 185 767057 SGTC_224 benfluorex 43.875 µM 2.00849455538903 0.0282797074634288 no 136 0.0222953820210014 120 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_781 4335-2806 94.4 µM 2.00763904802371 0.0283325832168552 no 137 0.0223408309893554 229 845254 SGTC_2679 rapamycin 1 nM 2.00685913355329 0.0283808585202552 no 138 0.0223823321480706 383 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1956 st077085 54 µM 2.00631746326159 0.0284144271991118 no 139 0.022411193999477 242 24208685 SGTC_3321 9137793 26.8275 µM 2.00286743662872 0.0286290102405099 no 140 0.0225957595611591 276 4904192 SGTC_1260 0700-1617 7.75 µM 2.00194812930954 0.0286864157319008 no 141 0.0226451552712743 262 2853078 SGTC_2726 cimetidine 79.27 µM 1.99822626854909 0.0289198037786305 no 142 0.022846067436474 139 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1449 4112-4002 201 µM 1.99741564211325 0.0289708447702245 no 143 0.0228900249950353 193 2059539 SGTC_2367 9070478 135.38 µM 1.99209012343211 0.0293080300106167 no 144 0.0231805852131953 240 572802 SGTC_1613 st002381 52.1 µM 1.99018583489785 0.0294293883793539 no 145 0.0232852340604594 224 551167 SGTC_3187 9109394 49.47 µM 1.98438818301382 0.0298014381032718 no 146 0.0236062911756946 249 17098090 SGTC_200 k038-0079 37.545 µM 1.98406094153821 0.0298225538170735 no 147 0.0236245233213155 229 3436683 SGTC_1722 st034304 3.6505 µM 1.98288304618408 0.0298986619270578 no 148 0.0236902474154572 248 4036148 YLR033W RSC58 SGTC_1073 triclabendazole 3.09 µM 1.97774816653846 0.0302323295154419 no 149 0.0239785617747636 273 50248 An antihelmetic and likely tubulin inhibitor. SGTC_584 0986-0246 15.4 µM 1.95926006707965 0.0314593559388051 no 150 0.0250411688945731 229 53315 YDR232W HEM1 SGTC_731 3966-0296 387 µM 1.95839135128005 0.0315180094743452 no 151 0.025092054419741 224 660956 SGTC_871 0574-0004 149 µM 1.95433639996296 0.0317929866486304 no 152 0.0253307233965835 277 9551173 SGTC_2147 5545932 89.7195 µM 1.93626025166528 0.033042993487303 no 153 0.0264179171936306 201 797404 SGTC_235 0330-0087 5 mM 1.9342686300812 0.0331831621888692 no 154 0.0265400540445269 259 46494818 YHR062C RPP1 SGTC_1169 aniline yellow 25.8 µM 1.93125280977017 0.033396345253563 no 155 0.0267258980519411 191 6051 A DNA damaging agent. SGTC_89 0302-0250 142.109 µM 1.93111394048216 0.03340618877743 no 156 0.0267344817082976 260 4203518 YLR208W SEC13 SGTC_2236 dapsone 200 µM 1.92954079176317 0.0335178657745632 no 157 0.0268318805502633 227 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_17 0960-0276 49.807 µM 1.91965848676231 0.0342264542661759 no 158 0.0274505255781304 288 6821114 SGTC_2703 st077852 53.4 µM 1.91694687867283 0.0344230226758849 no 159 0.0276223403219267 244 6281836 SGTC_1772 st048439 82.2 µM 1.91353235645147 0.0346718648450776 no 160 0.0278399676776954 286 2927068 YDL195W SEC31 SGTC_316 k060-0003 58.6 µM 1.91316598590693 0.0346986525906669 no 161 0.0278634032298989 220 6152314 SGTC_121 0557-0495 61.343 µM 1.91306836006926 0.0347057935210479 no 162 0.0278696508149524 387 3104427 SGTC_2543 pimpinellin 60.67 µM 1.90096639258901 0.035600395089084 no 163 0.0286532073687147 244 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_595 3909-8003 73.7 µM 1.89907521129171 0.0357418879881203 no 164 0.0287772939142098 250 699517 SGTC_2125 5246583 200 µM 1.89807563344474 0.0358168595719184 no 165 0.0288430597371268 317 835267 SGTC_2253 7938677 135.83 µM 1.88877825980292 0.0365203837966734 no 166 0.0294607735173949 225 2301972 SGTC_1934 st074720 32.6 µM 1.87699818427129 0.0374279688422036 no 167 0.0302591713611577 322 17250992 SGTC_2729 fluphenazine 10.66 µM 1.87698548661029 0.0374289569705723 no 168 0.0302600415283549 269 3372 An atypical antipsychotic. SGTC_88 0180-0332 8.668 µM 1.87665351054753 0.0374547988148096 no 169 0.0302827991163824 259 3101745 SGTC_460 trequinsin 123 µM 1.87303020106043 0.0377377947615276 no 170 0.0305321073359433 199 5537 A vasodilator. SGTC_2157 5649910 96.377 µM 1.87018631905318 0.0379611345573767 no 171 0.0307289744341024 275 2858091 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.8691735939307 0.0380409272551373 no 172 0.0307993333928649 144 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.8628106706818 0.0385453980675332 no 173 0.0312444541082107 219 6857784 SGTC_1663 st014140 55.4 µM 1.86055282759966 0.0387257116148208 no 174 0.0314036758401327 281 4207120 SGTC_1871 st057448 67.3 µM 1.8597142502224 0.0387928559769409 no 175 0.0314629824049569 284 691747 SGTC_2390 9097792 176.6 µM 1.85751326303799 0.03896953879794 no 176 0.0316190830052271 233 4497149 SGTC_2761 levamisole 97.89 µM 1.85386407726155 0.0392639181833056 no 177 0.0318793041819546 247 26879 An alkaline phosphatase inhibitor. SGTC_2060 5238662 140 µM 1.85242593581387 0.0393804289066736 no 178 0.0319823419258355 256 790130 SGTC_957 1187-1561 14.1 µM 1.85078515992002 0.0395136993869874 no 179 0.0321002334248634 299 1538454 SGTC_742 0kpi-0133 140 µM 1.84971349184274 0.0396009425065901 no 180 0.0321774274425626 280 2728852 SGTC_1418 3966-3099 2.4 µM 1.84405000402217 0.0400646047066283 no 181 0.0325879265676936 283 740335 SGTC_1908 st060353 56.5 µM 1.84395731866289 0.0400722292614294 no 182 0.0325946803131924 321 4227716 SGTC_3255 9139072 49.47 µM 1.84347644789977 0.0401118059523236 no 183 0.0326297386719961 253 17646060 SGTC_2159 5658611 73.75 µM 1.84054491560507 0.0403537647385485 no 184 0.032844138189901 208 793844 SGTC_1921 5740136 50 µM 1.83655717150911 0.0406848009954659 no 185 0.033137647404563 334 1774243 SGTC_2276 7947513 42.08 µM 1.83624545421255 0.040710770312647 no 186 0.033160681447786 261 2105100 SGTC_1098 clofazimine 15.1 µM 1.83509640780808 0.0408066141254643 no 187 0.0332457030508206 316 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2904 7225135 42.03 µM 1.83498263379281 0.0408161141524476 no 188 0.0332541313130153 252 4446116 SGTC_791 1348-1292 225 µM 1.82784413023915 0.0414157702223794 no 189 0.0337864739966909 359 5437054 SGTC_2731 amoxapine 43.43 µM 1.81692450280438 0.0423468468524263 no 190 0.0346143371201674 123 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_3276 9139060 49.47 µM 1.8155778778339 0.0424628324171135 no 191 0.0347175748274143 188 4870619 SGTC_2386 9075165 157.42 µM 1.81482728229311 0.042527593067599 no 192 0.0347752281721592 222 16452277 SGTC_37 0566-0070 1.56 µM 1.81290608979436 0.0426937155776571 no 193 0.034923153411559 314 1626686 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.80705500509006 0.0432028836432192 no 194 0.0353768516322925 162 279621 SGTC_1155 4088-0394 48.2 µM 1.80598236926733 0.0432967554494029 no 195 0.035460546777689 284 2326248 SGTC_3302 9125395 16.351 µM 1.80066932812691 0.0437641576849756 no 196 0.0358775073752266 271 17599668 SGTC_1157 4092-0394 27.6 µM 1.79854694628383 0.0439520034185395 no 197 0.0360451880476181 324 3659885 SGTC_1812 st052057 4.327 µM 1.79356703500908 0.0443953139467229 no 198 0.0364411510440283 294 3645418 SGTC_187 1488-2104 32.728 µM 1.79192578654238 0.0445422044402709 no 199 0.0365724273568473 302 2852859 SGTC_1234 0326-0494 15.5 µM 1.78850199560473 0.044849891415939 no 200 0.0368475269896876 253 1547813 SGTC_2100 5377183 190 µM 1.7864881514718 0.0450316680333267 no 201 0.0370101269897125 296 2844202 SGTC_2089 5281248 129.67 µM 1.78523654235603 0.0451449411179427 no 202 0.0371114784968788 301 2737878 SGTC_375 3970-0961 9.27 µM 1.77976504418684 0.0456428170319194 no 203 0.0375572102808906 303 2898222 SGTC_869 0564-0080 44.1 µM 1.77874338145503 0.0457362699126147 no 204 0.0376409217079646 324 6843321 SGTC_2025 5147754 141 µM 1.77700849163909 0.0458953149137103 no 205 0.0377834213515586 252 315777 YLR208W SEC13 SGTC_312 4092-0653 6.84 µM 1.77018763216792 0.0465249261571342 no 206 0.0383479444767822 413 1148278 SGTC_1305 1181-0477 144 µM 1.76645685443938 0.0468722238090391 no 207 0.0386596169650723 274 6252086 SGTC_2154 5570129 200 µM 1.7629997222022 0.0471959010923368 no 208 0.0389502682587359 315 673366 SGTC_314 1671-0008 2.74 µM 1.76255636018842 0.047237540590687 no 209 0.0389876714076336 356 3913060 SGTC_734 2023-0417 80 µM 1.75937573311578 0.0475371214433729 no 210 0.0392568554431707 315 3935732 SGTC_3280 9140961 49.47 µM 1.75741451196742 0.0477226046875711 no 211 0.039423590770963 248 4901226 SGTC_190 3970-0790 3.722 µM 1.75427830968783 0.0480204161626268 no 212 0.039691415265018 265 2832352 SGTC_3022 9087993 49.47 µM 1.74609098472515 0.0488048918820472 no 213 0.0403975715505535 249 17173644 SGTC_411 enrofloxacin 100 µM 1.7386631483475 0.049525426216162 no 214 0.0410470158806095 282 71188 A bacterial gyrase inhibitor. SGTC_1004 4084-0029 199 µM 1.73812365678627 0.0495780883654211 no 215 0.0410945136534804 314 716894 YLR208W SEC13 SGTC_1136 pergolide 1.05886 µM 1.73293923552831 0.0500864437781922 no 216 0.0415532348065364 427 47811 A dopamine receptor agonist. SGTC_793 0488-0545 106 µM 1.73263865776186 0.0501160437458596 no 217 0.0415799568605692 304 292548 SGTC_1148 3909-7663 27.7 µM 1.73145079446143 0.0502331573309952 no 218 0.0416856968915795 305 4084526 SGTC_2258 7960471 200 µM 1.7305674509701 0.0503203891039825 no 219 0.0417644706061761 230 2974708 SGTC_1061 3448-9325 110 µM 1.72670506409019 0.0507032256532944 no 220 0.0421103228632591 259 723482 SGTC_2063 5246145 200 µM 1.72548977710619 0.0508241624707086 no 221 0.0422196222696993 338 711240 SGTC_97 0535-0701 19.132 µM 1.72504376144568 0.0508686043846836 no 222 0.0422597931689908 277 2832013 YGL099W LSG1 SGTC_1758 st042942 75.2445 µM 1.72300781177335 0.0510718636681664 no 223 0.0424435561920644 282 669317 SGTC_970 1315-0089 19.5 µM 1.71997172242309 0.0513761720796665 no 224 0.0427187909173691 291 6811083 YLR033W RSC58 SGTC_2008 4012253 172 µM 1.71945130008086 0.051428478714851 no 225 0.042766114006867 357 603940 SGTC_3316 9136639 10.545 µM 1.71890086713729 0.0514838477365196 no 226 0.0428162121240873 287 4903665 SGTC_2033 5192550 145 µM 1.71415178524512 0.0519635374859609 no 227 0.0432504265904618 291 182073 SGTC_1887 st057648 70.8 µM 1.71344320538128 0.0520354123745006 no 228 0.0433155167484659 307 688672 SGTC_697 0508-1955 564 µM 1.70844135981308 0.0525450242027374 no 229 0.0437772392043225 356 6243113 SGTC_1852 st056254 31.4 µM 1.70842129597269 0.0525470763504515 no 230 0.0437790992701446 293 442583 SGTC_3317 9138495 8.753 µM 1.70167896237405 0.0532402984616157 no 231 0.0444077831049689 342 17020139 SGTC_835 0312-0010 67.2 µM 1.70114943928941 0.0532950476877283 no 232 0.0444574646287301 282 1626196 SGTC_278 4092-0821 23.9 µM 1.69975168292399 0.0534397809414432 no 233 0.0445888216802084 311 877900 SGTC_3112 9123419 49.47 µM 1.69969672440162 0.0534454780803828 no 234 0.0445939929023142 348 17015854 SGTC_2349 9023730 187.07 µM 1.69952474126199 0.053463309395683 no 235 0.0446101784640534 340 4126287 SGTC_1010 4112-3296 15.2 µM 1.69920248688612 0.0534967336146152 no 236 0.0446405189912294 354 704384 SGTC_1097 itavastatin 7.23 µM 1.69899382026457 0.0535183853433628 no 237 0.0446601739973186 348 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2176 5809774 33.9695 µM 1.69847398824556 0.0535723545030104 no 238 0.0447091690226114 311 2870539 SGTC_2134 5324836 1.464 µM 1.69719003027409 0.0537058402820954 no 239 0.0448303696901656 253 699272 SGTC_3070 9117005 49.47 µM 1.68824345246716 0.0546432917009191 no 240 0.0456822525888669 239 8779016 SGTC_1031 k035-0009 16 µM 1.68662102699459 0.0548146724358107 no 241 0.0458381230681517 369 5180959 SGTC_392 N-ethylmaleimide 8.33 µM 1.68625544652507 0.0548533481795706 no 242 0.0458733042358783 303 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2681 menadione 3.18 µM 1.67918383307621 0.0556057251785875 no 243 0.0465581108843727 339 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_90 0870-0863 4.608 µM 1.67893385958914 0.0556324691650407 no 244 0.0465824673423082 363 1738164 SGTC_2689 tacrolimus 100 µM 1.67878574966794 0.0556483198334072 no 245 0.0465969034284738 355 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2621 lithochol-11-enic acid 100 µM 1.67535477496165 0.0560165000444016 no 246 0.0469323221593389 382 6708711 SGTC_172 1112-0046 2.638 µM 1.67301284657386 0.0562689153662567 no 247 0.0471623835361444 291 2802135 YIL048W NEO1 SGTC_2293 7624732 200 µM 1.67180959608483 0.0563989511301909 no 248 0.0472809369777817 317 894453 SGTC_1862 st057513 3.81 µM 1.66966566826203 0.0566312331421966 no 249 0.0474927649617586 317 5393163 SGTC_307 1501-1223 22.3 µM 1.66927626592215 0.0566735033703634 no 250 0.0475313208150546 319 2830329 SGTC_2452 5863136 48.41 µM 1.6692121353467 0.05668046722703 no 251 0.0475376729731499 338 2184096 SGTC_1178 0988-0033 191 µM 1.65786944454371 0.0579227946997857 no 252 0.0486719103557274 365 5392207 SGTC_1200 1643-0193 18.4 µM 1.65575328843255 0.0581569218060578 no 253 0.0488858954601576 353 5403974 SGTC_580 1123-0028 41 µM 1.64867714784211 0.0589452146505923 no 254 0.0496068971174806 416 1677248 YPR107C YTH1 SGTC_706 4262-0057 46.9 µM 1.64844901798248 0.0589707674719377 no 255 0.0496302821545863 355 883298 SGTC_2569 tetrandrine 100 µM 1.64612575663584 0.0592314911064694 no 256 0.0498689352978429 306 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_451 chloral hydrate 100 µM 1.63961742346417 0.0599666909612276 no 257 0.050542369028776 438 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_714 4296-0578 26.1 µM 1.6365681505421 0.060313595039354 no 258 0.0508603675029321 212 1589775 SGTC_3066 9117245 49.47 µM 1.63135072350874 0.0609108023544141 no 259 0.0514081680709348 350 17176980 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.62740583995837 0.0613654109595487 no 260 0.0518254660154531 378 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1120 ficusin 1.78878 µM 1.62686014049664 0.0614285055468897 no 261 0.0518834025970216 330 6199 A DNA cross-linker. SGTC_2865 9030313 51.95 µM 1.6259930564874 0.0615288633084798 no 262 0.0519755662327879 317 42562754 SGTC_447 ml7 120 µM 1.62310204004232 0.0618643998213973 no 263 0.052283796800601 356 4216 Selective myosin light chain kinase inhibitor. SGTC_1802 st050112 57.9 µM 1.6224092555204 0.0619450173661202 no 264 0.0523578743544151 345 4662563 SGTC_1547 harmine 94.2 µM 1.62202958877059 0.0619892329686681 no 265 0.0523985064157722 441 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1597 7-benzyloxygramine 47.5 µM 1.61994352843766 0.0622326129769572 no 266 0.0526222041205664 535 260807 SGTC_2872 9044037 25.97 µM 1.61628772266444 0.0626609315799103 no 267 0.0530160600120866 263 6465195 SGTC_854 0422-0053 192 µM 1.6120564991537 0.0631595315069268 no 268 0.0534748228295354 355 3596728 SGTC_1071 trifluoperazine 6.31 µM 1.59853832603604 0.0647732089372527 no 269 0.0549616114707879 395 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2171 5739187 198.077 µM 1.59368030019122 0.0653608732532969 no 270 0.0555038293698785 311 2262761 SGTC_1857 st056007 79.3 µM 1.59171473995152 0.0655998144791907 no 271 0.0557244074223849 322 619834 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.58773356191355 0.0660858567547171 no 272 0.0561733002110832 376 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1102 cgs 12066b 26.1 µM 1.58679115048973 0.0662013184472966 no 273 0.0562799768896395 328 6438352 A 5-HT1B full agonist. SGTC_3036 9090181 49.47 µM 1.58598493183115 0.0663002181280563 no 274 0.056371363867449 316 25236586 SGTC_2095 5432005 200 µM 1.58504208546075 0.0664160231755443 no 275 0.0564783862861814 327 783734 SGTC_519 k048-0011 62.8 µM 1.58387210804477 0.0665599432549154 no 276 0.0566114128893776 382 6836379 SGTC_771 0250-0039 27.3 µM 1.58322494249264 0.0666396553611224 no 277 0.0566851016779765 381 3005115 SGTC_620 0109-0052 432 µM 1.5742487026944 0.0677529028635568 no 278 0.0577149819590244 376 493037 SGTC_1406 3909-7906 11.9 µM 1.56881096740821 0.0684342536719489 no 279 0.0583459960615543 384 X1406 SGTC_2623 humulene 100 µM 1.5669846837924 0.0686642699195681 no 280 0.0585591358519977 327 6187145 An anti-inflammatory. SGTC_647 0140-0236 81 µM 1.56458605368474 0.0689672771250461 no 281 0.0588400005268626 418 990837 SGTC_1405 3909-7894 12 µM 1.56412673415696 0.0690254181140417 no 282 0.0588939043886577 378 7104060 SGTC_3239 9133757 49.47 µM 1.56361466338372 0.0690902809174446 no 283 0.0589540445912251 318 17036923 SGTC_32 0928-0142 34.1 µM 1.56328907985303 0.0691315462395475 no 284 0.0589923078313399 333 2244242 SGTC_95 0471-0001 561.058 µM 1.56303158736917 0.0691641949686276 no 285 0.0590225826677901 410 4015405 SGTC_2923 7992654 58.14 µM 1.56035977384313 0.0695036688284662 no 286 0.0593374426186227 394 2985126 SGTC_689 0833-0039 98 µM 1.55309298492224 0.0704334595136733 no 287 0.0602004608983234 390 5374726 SGTC_228 caffeine 993.056 µM 1.54733343936185 0.071177167147586 no 288 0.060891431141538 337 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3353 9151644 39.2805 µM 1.54517781161015 0.0714570603966881 no 289 0.0611516298927247 397 4909158 SGTC_96 0929-0093 37.281 µM 1.543903982327 0.0716228548577283 no 290 0.0613057976119637 382 6991579 SGTC_2189 6047310 154.431 µM 1.54285635014253 0.0717594298154967 no 291 0.0614328168042608 377 711535 SGTC_327 1273-0057 3.96 µM 1.54043458923134 0.0720759081054579 no 292 0.0617272277688203 378 3108138 SGTC_1470 k295-0292 231 µM 1.53524834881127 0.072757249516458 no 293 0.0623614181080977 412 5045612 SGTC_2567 aureobasidin a 60 nM 1.5336060923447 0.072974025587445 no 294 0.0625632943086101 454 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2853 9015042 58.44 µM 1.52896789971018 0.0735889317767505 no 295 0.0631362009598256 370 6457456 SGTC_2183 6420625 130.508 µM 1.52850745535659 0.0736501904848252 no 296 0.0631932969588476 482 2897619 SGTC_1900 st060200 72.8 µM 1.52291072165132 0.0743979145572201 no 297 0.063890521510737 406 688945 SGTC_2528 xanthyletin 44.79 µM 1.51384821184748 0.0756209381401087 no 298 0.0650321707677805 371 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3057 9095946 49.47 µM 1.51250359669213 0.0758036971014689 no 299 0.0652028991740711 390 24540043 SGTC_2781 5567276 71.43 µM 1.51014137663614 0.0761255824203456 no 300 0.0655036767657429 427 2853274 SGTC_2007 4011539 71.82 µM 1.50905565553269 0.076273875554203 no 301 0.0656422802667764 442 45595301 SGTC_752 1896-0090 130 µM 1.50757712835281 0.0764761734736109 no 302 0.0658313950475441 416 772567 SGTC_2388 9080168 200 µM 1.50381321374945 0.0769930090927663 no 303 0.0663147339424652 368 15943073 SGTC_2992 9074591 71.4286 µM 1.50295585065606 0.0771111068499657 no 304 0.0664252146030158 398 17741321 SGTC_836 0330-0104 1.35 µM 1.49967584416572 0.0775641833077939 no 305 0.0668491953610452 418 46494820 SGTC_2657 nystatin 74.44 µM 1.49840086106972 0.0777408448399286 no 306 0.0670145664147463 433 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_201 4262-0159 12.803 µM 1.49692867488379 0.0779452105611962 no 307 0.0672059090029187 353 1341029 SGTC_2648 atorvastatin 78.68 µM 1.48744705307585 0.0792712080062465 no 308 0.0684483886885594 389 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3091 9116372 49.47 µM 1.48220445670419 0.0800116757487465 no 309 0.0691429505493267 404 17169793 SGTC_2338 7999974 200 µM 1.46928334715868 0.081858976294347 no 310 0.0708779758588314 470 315925 SGTC_2560 caryophyllene 100 µM 1.46676494434208 0.0822227400257517 no 311 0.0712200045077846 486 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.46671411902561 0.0822300938612726 no 312 0.0712269202038909 522 688664 SGTC_2313 7726885 200 µM 1.46260385619724 0.0828264426316867 no 313 0.0717879037367548 439 726423 SGTC_2980 9014342 25.29 µM 1.4615307891644 0.0829826658545599 no 314 0.0719349161910652 433 2996599 SGTC_668 1682-0499 62.6 µM 1.46088521480188 0.0830767589764964 no 315 0.0720234723999509 519 682214 SGTC_3147 9097027 49.47 µM 1.4543120012692 0.0840393837016379 no 316 0.0729299123229227 451 25236841 SGTC_3145 9085516 49.47 µM 1.4526587803998 0.0842828051465056 no 317 0.0731592584671167 437 25236195 SGTC_68 0986-0284 82.829 µM 1.45216769946224 0.0843552140990834 no 318 0.0732274907851914 434 423278 YIL048W NEO1 SGTC_1850 st056238 17 µM 1.45172354737638 0.0844207436747862 no 319 0.0732892445825142 504 5393177 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.44353363860165 0.0856359263781708 no 320 0.0744351017976187 457 688669 SGTC_1492 4158-0558 28.5 µM 1.44345604856313 0.085647501144819 no 321 0.074446022516881 422 3967268 SGTC_1315 1237-0019 3.69 µM 1.43367966758596 0.0871153171093016 no 322 0.0758318485241929 463 825140 SGTC_3023 9089636 49.47 µM 1.42980574917476 0.0877021117382028 no 323 0.0763863892859531 458 17249241 SGTC_481 bay k-8644 50 µM 1.42783855656126 0.0880012151515276 no 324 0.076669166115547 444 2303 A calcium channel antagonist. SGTC_2973 9094665 17.96 µM 1.42609598187202 0.0882668010812805 no 325 0.0769203192396163 515 25237061 YIL048W NEO1 SGTC_1719 st032227 49.2 µM 1.4257237404501 0.0883236117786327 no 326 0.0769740504823719 462 3125804 SGTC_391 gliotoxin 8.33 µM 1.42461411372105 0.0884931223399441 no 327 0.0771343889882232 503 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2321 7390090 138.78 µM 1.42070269488896 0.0890925778090359 no 328 0.0777016043802328 417 649046 SGTC_3085 9117376 49.47 µM 1.41797720253411 0.0895120639164211 no 329 0.0780987103642233 454 16480349 SGTC_369 0957-0393 4.5 µM 1.41745872751891 0.0895920294914362 no 330 0.0781744264933195 439 6997992 SGTC_2283 7944793 200 µM 1.41678270543309 0.0896963736773085 no 331 0.0782732338112673 485 2970533 SGTC_2186 6124449 200 µM 1.41623621042856 0.089780791344399 no 332 0.0783531786694142 440 3834182 YLR033W RSC58 SGTC_2942 9052777 62.25 µM 1.41086072776594 0.0906142975400724 no 333 0.0791428419898325 524 6469503 SGTC_1317 1273-0028 910 nM 1.4095546185364 0.0908176835402714 no 334 0.0793356175553761 464 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1170 0310-0127 64.8 µM 1.40858866580899 0.0909683184706079 no 335 0.0794784161138756 493 774975 SGTC_2104 5389443 200 µM 1.40696066159795 0.0912226159305343 no 336 0.0797195270049318 531 2244536 SGTC_2987 9018338 71.43 µM 1.40476704483626 0.0915660962906204 no 337 0.0800452808519429 486 5055682 SGTC_2086 5274770 176.623 µM 1.40394822671736 0.0916945536089423 no 338 0.0801671335949945 457 689278 SGTC_3241 9133421 49.47 µM 1.40317534642934 0.0918159265818595 no 339 0.0802822786655474 381 17018221 SGTC_3172 9105863 49.47 µM 1.40231488202422 0.0919511936983141 no 340 0.0804106191565825 358 2348785 SGTC_1947 st076332 61.6 µM 1.40182951235151 0.0920275600745437 no 341 0.0804830816478081 395 24208416 SGTC_2733 amorolfine 100 µM 1.4012210155576 0.092123365173857 no 342 0.0805739958830726 340 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1193 1488-0126 41.5 µM 1.40061417317755 0.0922189833115239 no 343 0.0806647401698349 479 1384710 SGTC_1387 3342-1166 1.8 µM 1.39975165604323 0.0923550136521787 no 344 0.0807938496094709 384 3418228 SGTC_1143 3454-2408 5.08 µM 1.39742849338676 0.0927221456089175 no 345 0.0811423778751407 403 X1143 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.39661117846812 0.0928515631098178 no 346 0.0812652634651803 497 3256 An antibiotic and ribosome inhibitor. SGTC_387 norethindrone acetate 66.7 µM 1.39498055617461 0.0931101624991479 no 347 0.0815108515096782 435 541197 SGTC_756 0508-1999 28.3 µM 1.39415502986583 0.0932412849868641 no 348 0.0816353972402054 459 6753853 SGTC_1922 5578187 25 µM 1.39351144610343 0.0933436032358836 no 349 0.0817325931004872 476 1350412 SGTC_2368 9071271 200 µM 1.39328132911353 0.0933802078248148 no 350 0.0817673671899478 487 27209959 SGTC_1685 st024049 53.0905 µM 1.39227587101667 0.0935402699071612 no 351 0.0819194376439148 431 1941139 SGTC_2956 9076196 2.52 µM 1.39156945820787 0.0936528471406893 no 352 0.0820264064131753 489 16423868 SGTC_1866 st057638 64 µM 1.38657424876281 0.0944517630673998 no 353 0.0827858125639336 461 688802 SGTC_1897 st060201 15 µM 1.38636186090466 0.0944858426520225 no 354 0.0828182180832555 443 611878 SGTC_1502 4534-4282 27.7 µM 1.38520617816196 0.0946714414683335 no 355 0.0829947160596557 453 3278949 SGTC_893 0958-0369 48.9 µM 1.38443833146124 0.0947949035923982 no 356 0.0831121393480226 527 6819948 SGTC_298 1391-0729 10 µM 1.38253943632449 0.0951007365161057 no 357 0.0834030651757757 453 3237558 SGTC_538 2922-0838 53.3 µM 1.38107670610291 0.0953368164762265 no 358 0.0836276884715759 581 777039 SGTC_40 0327-0103 19.753 µM 1.37931468888186 0.0956217729526922 no 359 0.0838988747834094 487 409036 SGTC_530 4358-1714 28 µM 1.37803786276059 0.0958286547658705 no 360 0.0840957992183372 564 1564641 SGTC_1867 st057372 64 µM 1.37756351610576 0.0959055961091257 no 361 0.0841690458673082 493 688837 SGTC_926 2268-1401 59.4 µM 1.37435729262119 0.0964268529729402 no 362 0.0846653939058095 504 2931578 SGTC_1638 st008370 60.6 µM 1.3729855918043 0.0966504941271804 no 363 0.0848784129650644 520 24207134 SGTC_1539 benzyladenosine 56 µM 1.37217684226941 0.096782530499911 no 364 0.0850041963377503 463 92208 A nucleotide analog. SGTC_2211 7117706 200 µM 1.37157605761387 0.0968807002597025 no 365 0.0850977257113564 463 822771 SGTC_1752 st044819 83.042 µM 1.37016796026974 0.0971110734416792 no 366 0.0853172386502222 491 441209 YML126C ERG13 SGTC_2135 5326629 150.42 µM 1.36989122450147 0.0971563963088991 no 367 0.085360429733717 476 5020077 SGTC_888 0916-0002 6.97 µM 1.36976506711662 0.0971770630980546 no 368 0.0853801249761636 503 2802138 YIL048W NEO1 SGTC_1116 jasmonic acid  1.58368 µM 1.36600608604 0.0977943309795719 no 369 0.0859685265795717 507 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_345 1362-0200 395 µM 1.36318880720131 0.0982588413905394 no 370 0.0864115069256259 465 1419823 SGTC_757 1066-0008 322 µM 1.36067457505945 0.0986747486045659 no 371 0.0868082764031273 533 6842497 SGTC_2947 9072639 7.68 µM 1.35633757668742 0.0993952057595987 no 372 0.0874958923868052 554 16488146 SGTC_2153 5569715 200 µM 1.35529644059102 0.0995687290120593 no 373 0.0876615643023811 488 2054701 SGTC_2864 9034755 47.6 µM 1.35262461869497 0.100015046943886 no 374 0.0880877917138096 505 4930451 SGTC_999 SEC7.066 22.7 µM 1.34921878646276 0.100586094295384 no 375 0.0886333511440745 545 740511 YDR170C SEC7 SGTC_2817 7995342 71.43 µM 1.34817038123412 0.100762355621726 no 376 0.0888017943140521 435 18879975 SGTC_1955 wogonin 32.4 µM 1.34781234370517 0.100822601632336 no 377 0.0888593733720344 485 5281703 A flavanone. SGTC_1626 st003712 1.76 µM 1.34655121092796 0.101035018244092 no 378 0.0890624082497779 485 24207035 SGTC_1068 loratadine 26.9 µM 1.3397638586029 0.102183837438892 no 379 0.09016106451581 494 3957 A H1 histamine antagonist. SGTC_338 4055-0136 114 µM 1.33213341906533 0.1034866692527 no 380 0.0914081752184494 524 2900563 SGTC_1108 betulinic acid 729.144 nM 1.33135128873159 0.10362088942068 no 381 0.0915367247168577 529 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1770 st043884 66.3 µM 1.3294208838614 0.103952703716914 no 382 0.0918545758232486 528 670149 SGTC_2217 6934799 96.0675 µM 1.32758134744889 0.104269615128302 no 383 0.092158224947003 513 675606 SGTC_1567 st069303 68.4 µM 1.3251483244743 0.104689845909253 no 384 0.0925609804158257 563 5581319 SGTC_2268 7933382 153.85 µM 1.32269929433933 0.105114078825545 no 385 0.0929676991559106 607 935025 YOR257W CDC31 SGTC_1469 k284-2957 126 µM 1.32238014148907 0.105169455537068 no 386 0.0930207991044789 499 23884841 SGTC_3014 9081533 49.47 µM 1.32112110458934 0.105388118918472 no 387 0.0932304935613118 545 21367265 SGTC_1596 piperlongumine 63 µM 1.31748384907783 0.10602166665012 no 388 0.093838245655027 577 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1773 st048542 73.5835 µM 1.31622622673053 0.106241361946191 no 389 0.0940490617384996 549 3237138 SGTC_1516 st013856 110 µM 1.31611923611346 0.106260067408903 no 390 0.0940670127645945 498 5281404 A mutagen and neurotoxin. SGTC_394 menadione 8.33 µM 1.31497673991929 0.106459961484307 no 391 0.0942588599304291 549 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_654 1124-0271 80.9 µM 1.30945794613392 0.107429367465841 no 392 0.0951896370070488 568 5403748 SGTC_2611 pyromycin 23.93 µM 1.30415532702747 0.108366779349235 no 393 0.0960903139611131 533 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_308 4092-1169 104 µM 1.30339828299756 0.1085010904044 no 394 0.096219411201301 574 2268590 YDL196W YDL196W SGTC_217 ketoconazole 989 nM 1.30229169653768 0.108697630972626 no 395 0.0964083445429747 530 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_719 2810-4230 27.3 µM 1.29926917782204 0.10923576424201 no 396 0.0969257840542679 493 721079 SGTC_1879 gemcitabine 100 µM 1.29406076143074 0.110167563909871 no 397 0.097822216868674 552 60750 A nucleoside analog which inhibits DNA replication. SGTC_558 k064-0027 21.3 µM 1.28823833332309 0.111215945449705 no 398 0.0988315059544657 565 5088526 SGTC_2722 naftopidil 47.16 µM 1.28437430400253 0.111915630936981 no 399 0.0995055097112404 577 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2425 5628681 7.85 µM 1.28202951731213 0.112341748630391 no 400 0.099916145949004 647 5714958 SGTC_1786 berberine 21.6 µM 1.28139865496749 0.112456592796454 no 401 0.100026838180669 569 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2115 tiliquinol 12.7705 µM 1.27968399294614 0.112769158975159 no 402 0.100328148221941 521 71208 A bioactive hydroxyquinoline. SGTC_2203 7227154 166.4 µM 1.2794863667569 0.112805224131359 no 403 0.100362918733716 509 896304 SGTC_1105 epirubicin 18.1 µM 1.27798406218015 0.113079651627571 no 404 0.100627522965507 545 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2301 7769476 200 µM 1.27734659848399 0.1131962416172 no 405 0.100739954500389 500 977820 SGTC_741 4582-0002 126 µM 1.27569793568613 0.113498174231122 no 406 0.101031159300967 552 2912688 SGTC_3034 9090421 49.47 µM 1.2726389152868 0.11405991716988 no 407 0.101573101382128 503 17173761 SGTC_1548 st061468 90.8 µM 1.27202310988345 0.11417323961422 no 408 0.101682454185529 574 390799 SGTC_265 mycophenolic acid 32.932 µM 1.27060612466716 0.114434302174521 no 409 0.101934403490579 608 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1590 st077108 57.8 µM 1.26961704636767 0.114616779665955 no 410 0.102110537173858 545 5489485 SGTC_1489 4065-0444 182 µM 1.26949234006472 0.114639801731263 no 411 0.102132760407543 545 2877968 SGTC_2467 5474540 200 µM 1.26746243833216 0.115015005267972 no 412 0.102494993096015 564 5413519 SGTC_160 3453-0671 289.699 µM 1.26620410167114 0.115248032068721 no 413 0.102720009714012 575 5322268 SGTC_1574 spiramycin 23.7 µM 1.26448256291364 0.115567380965055 no 414 0.103028437724594 593 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1767 st044992 70.3 µM 1.26447308530277 0.115569140819259 no 415 0.103030137577378 573 9600693 SGTC_178 4092-0806 87.505 µM 1.26064847557158 0.116280869870053 no 416 0.103717762608674 659 2169044 SGTC_510 ag-490 170 µM 1.26058672812913 0.11629238602638 no 417 0.103728891401018 598 5328779 SGTC_3196 9111891 49.47 µM 1.25838409645002 0.116703715468347 no 418 0.104126440313046 540 18891510 SGTC_1152 3909-8331 15.9 µM 1.25596706468977 0.117156268805388 no 419 0.104563955714667 540 16001939 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.25443082120549 0.117444553040101 no 420 0.104842727855819 617 688801 SGTC_798 1287-0182 476 µM 1.25390646677657 0.117543065815059 no 421 0.104938002129784 640 1649755 SGTC_2852 9023854 51.95 µM 1.25105765637883 0.118079306681788 no 422 0.105456721375097 590 19798528 SGTC_1659 st012954 42.1 µM 1.25028247885264 0.118225519872066 no 423 0.105598188271365 560 24207262 SGTC_3223 9129970 49.47 µM 1.24374594599833 0.119463526381326 no 424 0.106796540070805 635 17248386 SGTC_2250 alverine citrate 130 µM 1.24346549725838 0.119516846691514 no 425 0.106848173785059 700 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_195 4234-0266 16.654 µM 1.24188987704793 0.119816723575676 no 426 0.107138597767638 633 2303354 SGTC_1277 0873-0036 22 µM 1.24183066901564 0.119828002563471 no 427 0.107149522292086 643 5965735 SGTC_194 1486-1323 56.904 µM 1.2413530054393 0.119919023708056 no 428 0.107237685787781 572 5178754 SGTC_2191 5911152 200 µM 1.2355322256191 0.121032119054949 no 429 0.108316245344146 579 2875902 SGTC_3117 9124945 49.47 µM 1.23469025844128 0.121193726460065 no 430 0.108472901392064 497 17592065 SGTC_2423 st077119 87.2 µM 1.23396788248772 0.121332500409857 no 431 0.108607436214144 597 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3055 9094636 49.47 µM 1.23254400587188 0.121606365099342 no 432 0.108872969403779 561 25236176 SGTC_1151 3909-8316 15.3 µM 1.23194421437311 0.12172185737115 no 433 0.108984961779368 603 800431 SGTC_1526 st051518 75 µM 1.23176127177744 0.121757099039832 no 434 0.109019137083984 556 673993 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.22917100981064 0.122256851025577 no 435 0.109503847893347 657 66535 A nucleotide analog. SGTC_2231 micatex 6.853 µM 1.22901741048875 0.122286530858011 no 436 0.109532639173952 560 20737 An antifungal of unknown mechanism. SGTC_115 0527-0192 112.043 µM 1.22849561411846 0.122387394785859 no 437 0.109630487404057 699 4233931 SGTC_1634 st006576 41 µM 1.22841096140929 0.122403763769436 no 438 0.109646367553068 589 3915356 SGTC_862 0452-0056 10.2 µM 1.22691977300265 0.122692361338532 no 439 0.109926372999984 594 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1803 st050068 52.4 µM 1.22397508359005 0.123263663711418 no 440 0.110480813543818 801 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2350 9023895 38.85 µM 1.22357827498147 0.12334079126478 no 441 0.110555679619507 598 2997209 SGTC_575 k072-0246 11.9 µM 1.22337390579232 0.123380527622897 no 442 0.110594252239753 612 6796779 SGTC_753 1322-0200 289 µM 1.22196672673961 0.123654374823704 no 443 0.110860104957834 605 5403907 SGTC_1964 st076914 61 µM 1.22069826955176 0.12390159024055 no 444 0.111100141601227 591 24208661 SGTC_2768 sulfasalazine 50.2 µM 1.21999297704738 0.124039197467954 no 445 0.111233768606156 596 5384001 An antioxidant and salicylic acid derivative. SGTC_2774 tamoxifen 10.92 µM 1.21651028740218 0.124720260912189 no 446 0.111895297295372 593 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_653 0203-0016 55.2 µM 1.2147283815914 0.125069733453954 no 447 0.112234852010385 613 295302 SGTC_2961 9083290 32.55 µM 1.21353306480093 0.125304545385337 no 448 0.112463040344404 564 17741490 SGTC_2971 9092186 9.93 µM 1.21313497908925 0.12538281491637 no 449 0.112539109212077 554 25236400 SGTC_399 oxolinic acid 75 µM 1.21015486074541 0.125969834258112 no 450 0.113109737621051 591 4628 A DNA gyrase inhibitor. SGTC_229 benomyl 22.8748 µM 1.20888197549898 0.12622114849575 no 451 0.113354095910212 634 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1816 st051957 91.6 µM 1.20715110189034 0.126563446791323 no 452 0.113686978911707 615 674121 SGTC_500 h-89 112 µM 1.20666985618612 0.126658732917673 no 453 0.113779656157177 658 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2783 7738165 71.43 µM 1.20608619825312 0.126774363578766 no 454 0.113892127963641 512 17201110 SGTC_649 1123-0311 367 µM 1.20597001143063 0.126797390555099 no 455 0.113914526799938 673 693629 YIL048W NEO1 SGTC_3273 9137859 49.47 µM 1.20477985751034 0.127033433940737 no 456 0.114144148931065 594 2377234 SGTC_2417 cerulenin 830 nM 1.20463148829903 0.127062881450268 no 457 0.114172797612713 573 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_476 mead acid 10 µM 1.20420226124593 0.127148098837084 no 458 0.114255706105773 537 5312531 An omega 9 fatty acid. SGTC_2606 farnesol 9.78 µM 1.20291417445626 0.12740407023386 no 459 0.114504767291878 631 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2850 9015429 58.44 µM 1.2012051186316 0.127744250415434 no 460 0.114835822175013 569 6457570 SGTC_2896 9052656 71.43 µM 1.19941183736228 0.128101873520051 no 461 0.115183923512396 714 6469436 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.19746792068059 0.128490321752267 no 462 0.115562111951883 613 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2714 st079313 56.9 µM 1.19667561796504 0.128648880002534 no 463 0.115716507005829 596 2939799 SGTC_414 piperonyl butoxide 100 µM 1.19489634231302 0.129005449216916 no 464 0.116063766072687 617 5794 A potent inhibitor of cytochrome P450. SGTC_1195 1502-0147 41.1 µM 1.19315486807852 0.129355106057206 no 465 0.116404363168783 653 817940 SGTC_754 3474-0146 171 µM 1.18926751852688 0.130137983980439 no 466 0.117167206389151 587 24762078 SGTC_118 0083-0097 135.343 µM 1.18814388782065 0.130364882883089 no 467 0.117388363042133 839 5207356 SGTC_1914 st062367 72.6 µM 1.18704366588529 0.130587319784112 no 468 0.117605198584285 601 978205 SGTC_3286 9117135 37.221 µM 1.18304594155514 0.131397766498044 no 469 0.118395470199719 605 3438150 SGTC_1027 k015-0025 8.67 µM 1.17704742592406 0.132620330739721 no 470 0.119588288720105 644 3598955 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.17585123916971 0.132865061015491 no 471 0.119827163395845 652 4213774 SGTC_925 2064-1272 59.6 µM 1.17503627010903 0.13303197518571 no 472 0.119990102676055 606 6815817 SGTC_1323 1348-1351 11.2 µM 1.17433231573343 0.133176268530293 no 473 0.120130972105254 611 6989654 SGTC_572 0960-0087 17.7 µM 1.17403828025589 0.133236570453521 no 474 0.120189846504189 672 6796365 SGTC_154 3389-1638 511.116 µM 1.17286576789984 0.133477220608115 no 475 0.120424819524522 566 5238686 SGTC_366 0181-0206 4.31 µM 1.16977873792691 0.134112241506848 no 476 0.121045011109465 672 274874 SGTC_2339 9000433 200 µM 1.16641183634615 0.134807196480909 no 477 0.121723987616235 577 2988954 SGTC_136 0097-0015 404.482 µM 1.16556745564574 0.134981870133985 no 478 0.121894686144828 693 4861337 SGTC_2922 7999257 32.47 µM 1.16296187674823 0.135521854111644 no 479 0.122422485190486 585 2988377 SGTC_2130 NSC 7 2.4545 µM 1.15714470909345 0.136732747857686 no 480 0.123606621456146 695 21448 SGTC_471 1-acyl-paf 4 µM 1.15544853748056 0.137087209215734 no 481 0.123953397638691 643 16759367 SGTC_2610 ononetin 44.17 µM 1.15509014466059 0.137162185446421 no 482 0.124026756806995 665 259632 SGTC_1662 st014054 52 µM 1.15391666376086 0.137407875126975 no 483 0.124267168338514 625 2838777 SGTC_3179 9107801 49.47 µM 1.15315032825288 0.137568483574744 no 484 0.124424343645199 656 4818259 SGTC_963 1269-2853 151 µM 1.15136051145923 0.137944092015221 no 485 0.124791976137858 621 3668223 SGTC_1362 1611-0397 101 µM 1.15021311402611 0.138185250874761 no 486 0.125028053107744 668 27816 SGTC_1500 4488-1866 171 µM 1.1496977113145 0.138293671215386 no 487 0.125134198661852 703 2900003 SGTC_2521 angolensin 13.4 µM 1.14773708758749 0.138706638661548 no 488 0.125538557871516 620 821428 A flavenoid. SGTC_254 nsc-64875 3.808 µM 1.14340466474287 0.139622156097923 no 489 0.126435308312187 657 56993 SGTC_2736 butenafine 14.65 µM 1.14321957565444 0.139661360001595 no 490 0.126473718296479 696 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_995 3931-2021 34.6 µM 1.14034552029578 0.140271077032299 no 491 0.127071190168284 647 730143 SGTC_1579 chlormadinone acetate 49.4 µM 1.13643549728357 0.141103468463527 no 492 0.127887173329098 685 45114258 A steroidal progestin. SGTC_2984 9022109 38.96 µM 1.13619511173054 0.141154752390505 no 493 0.12793745795273 647 6459207 SGTC_150 3970-0969 77.2 µM 1.13601813291246 0.141192517181889 no 494 0.127974487730446 755 6615640 SGTC_2646 retinol 96.75 µM 1.13534988111639 0.141335174481744 no 495 0.128114375077251 665 445354 A vitamin A analog and teratogen. SGTC_3331 9141060 1.957 µM 1.13501120498655 0.141407511799724 no 496 0.128185311804702 628 4906567 YPR165W RHO1 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.132068740418 0.142037044276192 no 497 0.128802767879788 735 1377 SGTC_2297 7971671 152.32 µM 1.13193686301278 0.142065303447201 no 498 0.128830489677871 661 909016 SGTC_1395 3486-0190 4.35 µM 1.13065872279226 0.142339385171634 no 499 0.129099380514479 712 6748079 SGTC_516 3992-2719 87.3 µM 1.12933768878321 0.142623040667036 no 500 0.129377703863429 616 5350887 YDR037W KRS1 SGTC_1288 0973-0013 65.5 µM 1.12858516283323 0.142784795559267 no 501 0.129536436301264 698 4315430 SGTC_3046 9092212 49.47 µM 1.12728849014714 0.143063805223337 no 502 0.129810263578826 672 25236637 SGTC_855 0428-0020 25 µM 1.12465959420863 0.143630603872881 no 503 0.130366654984641 623 6812414 SGTC_3294 9122953 26.2835 µM 1.1240358111281 0.143765315729235 no 504 0.130498917046745 695 16459826 SGTC_2868 9035608 32.47 µM 1.1219052171226 0.144226080365497 no 505 0.130951371102626 673 6462614 SGTC_827 3253-0474 693 µM 1.12116161164023 0.144387127420094 no 506 0.131109538429187 733 5402065 SGTC_2479 5617353 43.85 µM 1.12112296620245 0.144395500403639 no 507 0.131117762046538 690 2731746 SGTC_602 3130-1533 38.1 µM 1.1192229386407 0.144807567029145 no 508 0.131522520895332 742 720941 SGTC_3256 9138902 49.47 µM 1.1189148839924 0.144874450608679 no 509 0.131588226291163 710 17228773 SGTC_1785 bathophenanthroline 24 µM 1.11879767877269 0.144899903193562 no 510 0.131613231100771 669 72812 An iron chelator. SGTC_1467 k284-1082 293 µM 1.1187085952022 0.144919250822967 no 511 0.131632238571526 736 3334705 SGTC_1610 st001799 48.1 µM 1.11812521485292 0.145045995365493 no 512 0.131756759357477 619 621897 SGTC_2990 9074105 71.4286 µM 1.11721952887292 0.145242911449617 no 513 0.131950236301961 650 6502001 SGTC_3345 9148410 3.559 µM 1.1148519972122 0.145758514341273 no 514 0.132456925001407 669 4903596 SGTC_1407 3909-7909 12.3 µM 1.10597611931202 0.147702452114608 no 515 0.13436842789912 724 4411780 SGTC_2979 9012552 45.46 µM 1.10568360281118 0.147766811368387 no 516 0.134431744826274 637 17100905 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.10506905656536 0.14790208451759 no 517 0.134564833714697 751 676296 Flavone; oxidizing agent. SGTC_3186 9110464 49.47 µM 1.10244468060051 0.148480691580284 no 518 0.135134197935411 695 17018021 SGTC_2967 9089538 49.85 µM 1.10172136247192 0.148640430263268 no 519 0.135291413378801 727 728216 SGTC_703 3875-0075 71.8 µM 1.1006184876562 0.148884211878183 no 520 0.13553136789609 759 2850814 SGTC_1985 st071382 65.5 µM 1.10043803406838 0.148924125111948 no 521 0.135570657260404 705 6123237 SGTC_319 1348-1596 45.5 µM 1.10034133863127 0.148945515423157 no 522 0.135591713542476 740 5380505 SGTC_2480 5767542 37.17 µM 1.0958296061595 0.149945852877952 no 523 0.136576674780177 728 2867358 SGTC_1479 0549-0158 134 µM 1.09569884211786 0.149974912419318 no 524 0.136605294796365 773 5440202 SGTC_1261 0712-0010 12.7 µM 1.09057595527252 0.151116321143545 no 525 0.137729757259467 747 2840123 SGTC_2071 5230951 39.92 µM 1.09006010309077 0.15123157544516 no 526 0.13784333471383 760 1799272 SGTC_3235 9132602 49.47 µM 1.09001730800998 0.151241139564392 no 527 0.137852759965527 737 4912240 SGTC_21 0849-0113 22.993 µM 1.08904707473957 0.151458081483061 no 528 0.138066563558479 726 1560156 SGTC_256 clotrimazole 625 nM 1.08797636583659 0.151697729566776 no 529 0.138302770626514 697 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_609 0986-0026 86.3 µM 1.08462549016592 0.152449356558085 no 530 0.139043780302212 734 2848610 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.08278082460355 0.152864182127692 no 531 0.139452859386678 698 115019 SGTC_1438 4092-1045 4 µM 1.0827008162506 0.152882191204113 no 532 0.13947062080626 738 1351342 SGTC_2951 9072950 58.06 µM 1.08142543125846 0.153169457505345 no 533 0.139753957109593 777 16488155 SGTC_479 n-linoleoylglycine 10 µM 1.08069528222992 0.153334076377037 no 534 0.139916341188246 685 6433346 An anti-infammatory. SGTC_142 0335-0849 62.6745 µM 1.08040500234149 0.153399555221852 no 535 0.139980934621451 834 3889043 YPR107C YTH1 SGTC_1444 4112-3581 28 µM 1.07670098283426 0.154236702094327 no 536 0.140806936579062 751 2877249 SGTC_1246 0422-0085 105 µM 1.0739997028663 0.154849121108351 no 537 0.141411407361995 760 264295 SGTC_1111 tnp00062 510.699 nM 1.07348146633206 0.154966796176317 no 538 0.141527574943283 758 676306 SGTC_927 2425-1185 123 µM 1.07253676566379 0.155181459628795 no 539 0.141739504791458 717 730375 SGTC_1527 coumarin 137 µM 1.07248256655782 0.155193781192318 no 540 0.141751670088432 667 323 A hepatotoxic, DNA x-linker. SGTC_2099 5377090 177.372 µM 1.07149277486803 0.15541891290623 no 541 0.141973958834884 724 2243829 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.07037393207342 0.155673657106122 no 542 0.142225514063351 738 97141 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.06975847362803 0.155813905363164 no 543 0.142364019289605 820 65057 A dermal irritant. YDR527W RBA50 SGTC_2617 dihydrotanshinone i 20.83 µM 1.06957027019048 0.155856809051804 no 544 0.142406391554788 759 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2234 tolnaftate 200 µM 1.06843303791364 0.156116223260095 no 545 0.142662610406407 687 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_91 0417-1751 58.384 µM 1.06824899768355 0.156158231434203 no 546 0.142704104022128 846 6795624 SGTC_3305 9127027 53.8275 µM 1.06717138753199 0.156404351222422 no 547 0.142947225199521 735 41905295 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.06660397989115 0.156534046388041 no 548 0.143075351281238 784 4174840 SGTC_3213 9129884 49.47 µM 1.06635426878693 0.156591146520091 no 549 0.143131763020081 645 17190742 SGTC_463 ikarugamyin 104 µM 1.06498465736198 0.156904572229252 no 550 0.143441436397964 692 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1262 0737-0114 49.6 µM 1.06253159190897 0.157466969541546 no 551 0.143997211962954 819 765919 SGTC_193 1273-0060 1.558 µM 1.06227199978532 0.157526561848764 no 552 0.144056110975364 640 2847393 YHR072W ERG7 SGTC_1925 st057770 10.1 µM 1.06139978162059 0.157726897926577 no 553 0.144254128061972 667 5989122 SGTC_1486 3970-0793 4.53 µM 1.06138083518444 0.157731251509211 no 554 0.14425843144998 750 2844330 SGTC_573 3702-0553 84.7 µM 1.05822892293105 0.158456608470668 no 555 0.144975544098486 722 1222756 SGTC_469 w7 172 µM 1.05810155869747 0.158485965021094 no 556 0.145004571944919 712 45115570 A P450 inhibitor. SGTC_2323 6148992 148.28 µM 1.05759454725262 0.158602862917705 no 557 0.145120164759127 675 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_555 4296-0685 37 µM 1.05596255245457 0.158979523752662 no 558 0.145492661905144 774 2908540 YHR072W ERG7 SGTC_1652 st011932 78 µM 1.05275917586105 0.159720559091414 no 559 0.146225689843728 725 1551076 SGTC_2935 9038016 29.96 µM 1.05208021286961 0.159877913037693 no 560 0.146381374804621 796 6463195 SGTC_36 0335-0881 14.2 µM 1.05150556567522 0.160011170343474 no 561 0.146513227269185 798 23828853 SGTC_246 cycloheximide 667 µM 1.04686754088065 0.16108935902731 no 562 0.14758033713082 664 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_114 0364-0001 490.298 µM 1.04639221687891 0.16120012347703 no 563 0.147689992352651 756 4003655 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.04599240987811 0.161293328712475 no 564 0.14778226836518 791 688751 SGTC_2715 st079500 56.4 µM 1.04527517372224 0.161460622878128 no 565 0.147947904199358 702 28246688 SGTC_3165 9101544 49.47 µM 1.043068691614 0.161975990416988 no 566 0.148458239872909 765 5002184 SGTC_707 0865-0008 204 µM 1.04272547236663 0.16205625225965 no 567 0.14853772848391 805 723043 SGTC_1896 st058441 89 µM 1.04207955144592 0.162207371139578 no 568 0.148687399109812 695 688759 SGTC_2202 7226349 200 µM 1.04058440631451 0.162557525376705 no 569 0.149034235748951 745 844334 SGTC_454 lyso-paf C-16 6.67 µM 1.03595094367661 0.163645776417559 no 570 0.150112514599091 757 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_650 1328-0195 38 µM 1.03528399228553 0.163802810335446 no 571 0.150268151675631 779 2780821 SGTC_303 1348-1668 34.2 µM 1.03437687525518 0.16401654824847 no 572 0.150480005372611 751 5380509 SGTC_1844 rapamycin 4 nM 1.03437502989926 0.164016983241665 no 573 0.150480436551091 841 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2744 captopril 92.04 µM 1.0333073754958 0.164268779630678 no 574 0.150730038396205 703 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1255 0566-0045 221 µM 1.03068023197037 0.164889433703463 no 575 0.151345398913439 772 2788469 SGTC_1006 4099-6547 255 µM 1.03046215896684 0.164941020914236 no 576 0.151396553535835 769 3146833 SGTC_2473 5854593 8.94 µM 1.02752261518786 0.165637417315906 no 577 0.152087221016112 748 2872951 SGTC_1153 4055-0057 267 µM 1.02655634254096 0.16586674800526 no 578 0.152314710146995 785 882706 SGTC_3092 9117248 49.47 µM 1.02646182566187 0.165889191219157 no 579 0.152336974334593 838 17141857 SGTC_3300 9124615 50.48 µM 1.02555506848411 0.166104602180188 no 580 0.15255067782511 765 24824903 SGTC_1927 st060202 13.8 µM 1.02482474566992 0.166278230388555 no 581 0.152722944023033 772 688887 SGTC_591 4299-0174 154 µM 1.02438112536254 0.166383754650704 no 582 0.152827646723762 770 5509088 SGTC_1612 st002233 45.4 µM 1.02164326216705 0.167035968705139 no 583 0.153474886968409 768 1035021 SGTC_2654 protoveratrine a 100 µM 1.02021621440205 0.167376572896325 no 584 0.153812964683163 770 5702278 A heart drug and vasodilator. SGTC_2844 9010103 25.97 µM 1.01943263196508 0.167563786604897 no 585 0.153998810393158 749 2480525 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.01747345892843 0.168032462713945 no 586 0.154464126006156 706 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3340 9146634 11.102 µM 1.01367729570409 0.16894298469282 no 587 0.155368380617073 786 4907387 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.01355025987973 0.168973509349625 no 588 0.155398701120056 767 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3211 9128781 49.47 µM 1.0110900915759 0.16956534658352 no 589 0.155986656139091 743 17194361 SGTC_2114 5491910 81.25 µM 1.00895820587639 0.170079283835139 no 590 0.156497339244616 783 2849228 SGTC_1360 1598-0022 39.8 µM 1.00530863628374 0.170961406419477 no 591 0.157374128911082 869 761525 SGTC_2317 5986382 200 µM 0.998125127875762 0.172706236524783 no 592 0.15910934337864 846 877883 SGTC_1530 rhein 70.4 µM 0.997335660603572 0.172898683241331 no 593 0.159300804903885 854 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_799 1310-0557 151 µM 0.995080081407406 0.173449273459934 no 594 0.159848658709215 803 5354492 SGTC_1051 3253-3903 78 µM 0.993249926031175 0.173896836285796 no 595 0.160294086694716 827 5509239 SGTC_2091 4-phenylthiadiazole 200 µM 0.991960061353629 0.174212712309791 no 596 0.160608504194453 821 270010 SGTC_3224 9130643 49.47 µM 0.991909626767281 0.174225070680249 no 597 0.160620806310404 767 17644395 SGTC_709 3807-1509 243 µM 0.990307196392186 0.174618016418885 no 598 0.161011995092968 811 1886677 YPL242C IQG1 SGTC_2566 crystal violet carbinol 226 nM 0.989284183433928 0.174869172305924 no 599 0.161262060158172 674 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_133 0724-0033 378.92 µM 0.987298017124618 0.175357442454369 no 600 0.161748281227415 779 280309 SGTC_2798 7813637 45.45 µM 0.985575390050608 0.175781624552235 no 601 0.16217075972472 807 956368 SGTC_962 1254-0300 21.5 µM 0.984510568071627 0.176044152589854 no 602 0.162432268944032 811 7340576 SGTC_2892 9047358 58.44 µM 0.979650897274547 0.177245436315173 no 603 0.163629235932325 752 6466771 SGTC_2809 7964133 12.99 µM 0.979072686247123 0.177388710710231 no 604 0.163772033156053 811 1253665 SGTC_2591 skatole 100 µM 0.975521599554276 0.17827023409293 no 605 0.164650796419664 806 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_956 1185-0240 191 µM 0.973807433895981 0.178696745590351 no 606 0.165076080659584 801 1416193 SGTC_2334 9017922 200 µM 0.973150754409541 0.178860307892304 no 607 0.165239190974064 842 3163164 SGTC_2265 7929201 200 µM 0.973128793176191 0.178865779509635 no 608 0.165244647649641 851 1265108 SGTC_158 k038-0087 26.446 µM 0.971618764991058 0.179242254028599 no 609 0.165620121817097 896 X158 SGTC_3348 9149464 3.537 µM 0.971338219978825 0.17931225330607 no 610 0.165689941113159 836 1951442 SGTC_3228 9131799 49.47 µM 0.969371385663712 0.179803484174698 no 611 0.166179961902909 800 17015818 SGTC_2686 alizarin 95.37 µM 0.967551092596895 0.180258867795662 no 612 0.166634306377622 774 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1986 st071812 45 µM 0.966106895952474 0.180620677649348 no 613 0.166995347115606 798 11838594 SGTC_2228 7354201 200 µM 0.965712470127305 0.180719570977614 no 614 0.167094038910251 857 753451 SGTC_1019 4262-0212 3.4 µM 0.965287264797834 0.180826219585608 no 615 0.167200474355096 913 4677213 SGTC_698 k064-0052 127 µM 0.962877726329135 0.181431317085033 no 616 0.16780444429117 848 5088751 SGTC_3009 9080819 71.4286 µM 0.961528594160764 0.181770672025089 no 617 0.16814322764433 841 17027216 SGTC_2897 9048598 12.99 µM 0.961318259621669 0.181823614432781 no 618 0.168196084809052 800 6467404 SGTC_1086 cerivastatin 2.18 µM 0.959676646346015 0.182237149240662 no 619 0.168608990213361 824 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2332 7982454 138.89 µM 0.959111258804866 0.182379710619093 no 620 0.168751349563707 852 2981748 SGTC_1296 1068-0102 11.9 µM 0.958293353981704 0.182586067012569 no 621 0.168957427078853 852 767053 SGTC_816 0325-0417 81.3 µM 0.957889304295916 0.182688062044752 no 622 0.169059290185866 828 68101 SGTC_424 splitomicin 100 mM 0.957747690731944 0.182723818244045 no 623 0.169095001062039 768 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_286 k060-0067 22.9 µM 0.952401074171196 0.184076987856675 no 624 0.170446807454419 829 5985051 SGTC_678 1218-2179 85.9 µM 0.950376377349401 0.184591040608732 no 625 0.170960521329678 837 6820081 YOR116C RPO31 SGTC_3037 9091026 49.47 µM 0.950063909119659 0.184670452990719 no 626 0.171039890110737 936 25236398 YIL048W NEO1 SGTC_1290 0986-0249 10.2 µM 0.948961993816873 0.184950669259533 no 627 0.171319971200726 805 53329 SGTC_1015 4130-4525 82 µM 0.947906716856694 0.185219272961707 no 628 0.171588472601749 853 1363237 SGTC_2427 5545055 42.75 µM 0.944986632200947 0.185963795136887 no 629 0.172332850372559 912 5372858 SGTC_1013 4112-3890 241 µM 0.94462806428095 0.186055345496573 no 630 0.172424397061311 835 705171 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.942419022147239 0.186619979144926 no 631 0.172989076035886 847 641818 YHR062C RPP1 SGTC_2274 7947094 46.08 µM 0.941603756243586 0.186828629775376 no 632 0.173197772956141 934 2971028 SGTC_1618 st003135 44.5 µM 0.941043515910711 0.186972095489705 no 633 0.173341279728596 849 1270615 SGTC_1967 st070177 51.4 µM 0.930393591875133 0.189712265462568 no 634 0.17608366761432 855 5729214 SGTC_1310 1188-0297 994 nM 0.929227294660492 0.190013840992272 no 635 0.176385652498702 883 1588352 SGTC_1847 st056231 15 µM 0.927753187549573 0.19039542983446 no 636 0.176767805909656 923 5393180 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.927712859914448 0.190405875695777 no 637 0.176778267956831 909 94937 An inhibitor of serotonin biosynthesis. SGTC_1440 4100-1550 40 µM 0.927070400552899 0.190572336125357 no 638 0.17694499156672 900 742806 SGTC_2486 5283202 22.39 µM 0.922997226914497 0.191629767811274 no 639 0.178004325184638 816 1377751 SGTC_1992 st073643 23.3 µM 0.922977456913954 0.191634909025357 no 640 0.178009476614477 860 3161292 SGTC_928 2764-0428 58.7 µM 0.920068553794451 0.192392293491511 no 641 0.178768468011841 910 662578 SGTC_237 nikkomycin 200 µM 0.919246479866125 0.19260666628536 no 642 0.178983332344156 919 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_807 1315-0151 48 µM 0.917745408057079 0.192998478308689 no 643 0.179376084483367 968 4011080 SGTC_1223 0764-0573 147 µM 0.916889510515021 0.193222103699904 no 644 0.17960027057575 918 1609797 SGTC_3159 9100096 49.47 µM 0.916047906277933 0.193442148739133 no 645 0.179820884426567 887 25236875 SGTC_3088 9117578 49.47 µM 0.916029671525424 0.193446918071532 no 646 0.179825666275067 902 678341 SGTC_2815 7968870 71.43 µM 0.915014012893002 0.193712678681334 no 647 0.180092136874922 888 2977326 YHR190W ERG9 SGTC_1853 st056710 91.2 µM 0.913350294096602 0.194148493560354 no 648 0.180529169372509 958 269167 SGTC_1806 st050005 60.3 µM 0.912964846938894 0.194249547457662 no 649 0.180630515047743 873 5194765 SGTC_2704 st078022 71.1 µM 0.911229988991183 0.194704777043377 no 650 0.181087103028455 917 54697681 SGTC_3171 9103192 49.47 µM 0.911145237063241 0.194727032704492 no 651 0.18110942694352 914 13018434 SGTC_2070 5230947 200 µM 0.910335681569544 0.1949396980977 no 652 0.181322753195618 963 2835538 SGTC_1645 Cervolide 78 µM 0.90935395273223 0.195197781788647 no 653 0.181581659904999 857 23173 A fragrance. SGTC_2680 butyl paraben 22.24 µM 0.909140166651903 0.195254010877322 no 654 0.181638071360472 888 7184 An antifungal and steroid mimetic. SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.908319509707776 0.195469947901131 no 655 0.181854718874472 968 16486 A toxic proline analog. SGTC_2393 9031399 185.94 µM 0.905648834212609 0.196173678232311 no 656 0.1825608761509 908 1526623 YDL150W RPC53 SGTC_2937 9044753 11.33 µM 0.903348582469677 0.196781030688413 no 657 0.183170459883944 941 6465530 YGL099W LSG1 SGTC_374 0880-0231 82.3 µM 0.902688255868123 0.196955591739724 no 658 0.183345685590424 917 6833587 SGTC_2721 ifenprodil 61.44 µM 0.902555149583877 0.196990790483461 no 659 0.183381019617388 886 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2546 rhodinyl acetate 100 µM 0.899308913985288 0.197850406250374 no 660 0.184244070325927 933 6708682 SGTC_1651 st011928 86.1 µM 0.898716381488153 0.198007555375659 no 661 0.184401874571463 892 720198 SGTC_2821 7996764 71.43 µM 0.897700850384593 0.198277065769441 no 662 0.184672527991348 948 2987135 SGTC_1433 4060-0023 7.6 µM 0.89759518248883 0.19830512153797 no 663 0.184700704161848 924 3840627 SGTC_1347 1493-0251 600 nM 0.894988400835593 0.198998003681224 no 664 0.185396644252239 979 3986378 SGTC_802 4112-3352 742 µM 0.894609549538623 0.199098823571592 no 665 0.18549792259896 966 704594 SGTC_1241 0364-0022 50.8 µM 0.894105101521079 0.199233115012351 no 666 0.185632830016709 923 4563895 SGTC_462 ag-879 158 µM 0.893305782189031 0.199446017183881 no 667 0.185846721175872 958 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2311 7694451 200 µM 0.892807192862178 0.199578887945884 no 668 0.185980216878113 887 2163142 SGTC_2006 4011487 200 µM 0.889336811470775 0.200505196603902 no 669 0.186911046713937 951 45595294 SGTC_1707 st032323 6.317 µM 0.889334605381634 0.200505786269677 no 670 0.186911639349161 906 3132057 YMR211W DML1 SGTC_70 0141-0289 43.283 µM 0.887437230731283 0.201013321270109 no 671 0.187421773183796 1057 352408 SGTC_726 3448-4391 34.2 µM 0.885259392932815 0.201596827240399 no 672 0.188008372849999 964 1356692 SGTC_3151 9099821 49.47 µM 0.885066643030741 0.201648519367563 no 673 0.188060344490076 915 17174189 SGTC_3182 9108849 49.47 µM 0.884375578649521 0.201833915908101 no 674 0.188246750795861 963 17133045 SGTC_1299 1079-1439 3.74 µM 0.882952772508941 0.202215943017195 no 675 0.188630894463317 907 323161 SGTC_429 1112-0049 25.5 µM 0.88240661253968 0.202362703194154 no 676 0.188778480552513 861 2836170 SGTC_2019 4016004 108 µM 0.88163989090079 0.202568838560618 no 677 0.188985787963041 859 45595336 SGTC_903 1134-0042 114 µM 0.881099430444527 0.202714218335451 no 678 0.189132002751976 916 701009 SGTC_2867 9039098 71.43 µM 0.880777246052433 0.202800913153868 no 679 0.189219198826748 879 6463460 SGTC_2734 clemastine 41.6 µM 0.879707603377479 0.203088896199977 no 680 0.189508864676374 848 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1859 st055998 20 µM 0.879672445982955 0.203098365871399 no 681 0.189518390145422 969 676301 SGTC_2495 cafestol 54.53 µM 0.877289790054455 0.203740750242815 no 682 0.190164628209576 876 16667697 An anti-infammatory. SGTC_1366 1683-0113 21.9 µM 0.877171929395359 0.203772557891704 no 683 0.190196630182271 929 708623 SGTC_1629 st005085 44.9 µM 0.876582018802555 0.203931804511983 no 684 0.190356854663143 918 24207091 SGTC_864 0469-0573 172 µM 0.87590383766363 0.20411497141036 no 685 0.190541156539666 889 689425 SGTC_2051 5263410 176 µM 0.875020129167826 0.204353795254662 no 686 0.190781476660017 984 227584 SGTC_1980 st071811 45.7 µM 0.873621841497395 0.204732024745008 no 687 0.191162113798688 939 4974850 SGTC_2677 mitomycin C 100 µM 0.873007524016259 0.204898325974975 no 688 0.191329488339455 924 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3169 9102970 49.47 µM 0.872578267102738 0.205014577311599 no 689 0.191446495291403 977 17027839 SGTC_1704 st028805 70.8 µM 0.870990897051292 0.205444809227545 no 690 0.191879561720812 929 2876101 SGTC_231 b-estradiol 524 µM 0.870765103622545 0.205506050544689 no 691 0.191941211384213 868 450 A steroid. SGTC_576 1073-0113 22.7 µM 0.870384987041882 0.205609172976861 no 692 0.192045024156209 1166 5439563 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.86778712789614 0.206314772281828 no 693 0.192755439002309 952 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_912 3474-0017 2.18 µM 0.867563254005292 0.206375645309826 no 694 0.192816734981828 968 3360550 SGTC_2286 7945697 125 µM 0.86571128834851 0.206879617020467 no 695 0.193324254019315 949 1245733 SGTC_1238 0333-0287 48.8 µM 0.863557574525596 0.20746661803984 no 696 0.193915489308394 945 7226 SGTC_819 1013-0258 27.7 µM 0.862584775877274 0.207732079603055 no 697 0.194182901873034 952 5753198 SGTC_2785 7756463 72.73 µM 0.862452391166863 0.207768220827906 no 698 0.194219310453345 967 2201551 SGTC_2810 7959871 45.46 µM 0.86158976139207 0.208003810985219 no 699 0.194456653581443 984 2974535 SGTC_1625 st003711 30.1 µM 0.861416435550856 0.208051166490853 no 700 0.194504363579097 967 24207034 YER133W GLC7 SGTC_3295 9122362 53.5725 µM 0.860943781622256 0.208180335748814 no 701 0.194634503390304 910 4730473 SGTC_381 3461-2219 42.7 µM 0.859602410181329 0.208547170152054 no 702 0.195004122994672 971 2883159 SGTC_2018 5133068 143 µM 0.857501772108355 0.209122411738278 no 703 0.195583817931214 894 785362 SGTC_944 3370-0224 231 µM 0.856644672862052 0.209357389069924 no 704 0.195820644459002 959 4580514 SGTC_2272 7805186 180 µM 0.85596745458285 0.209543161121903 no 705 0.196007890797202 965 2956062 YPR165W RHO1 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.855492303330032 0.209673560747468 no 706 0.196139331764343 913 4620898 SGTC_2996 9066192 71.4286 µM 0.854549184054364 0.209932529961475 no 707 0.196400384902409 945 6472854 SGTC_3154 9100113 49.47 µM 0.854440677973103 0.209962336479603 no 708 0.196430432625667 955 25237525 SGTC_619 1652-1634 108 µM 0.852720775165438 0.210435124192504 no 709 0.196907083577566 902 5400454 SGTC_2424 5537928 59.2 µM 0.852374977204028 0.210530256722934 no 710 0.197003001917404 998 5382802 SGTC_3222 9128301 49.47 µM 0.851891499242243 0.210663308725038 no 711 0.197137157698411 966 4911358 SGTC_769 0302-0231 76 µM 0.851188796725251 0.210856778743862 no 712 0.197332242586897 1025 571869 YER009W NTF2 SGTC_641 4092-0595 30 µM 0.851179028874196 0.210859468789929 no 713 0.197334955168842 978 786260 SGTC_901 1112-0062 60.1 µM 0.84881158177383 0.211512052204785 no 714 0.197993072264995 962 1908457 SGTC_2314 7727897 200 µM 0.848517925535664 0.211593080485743 no 715 0.198074796889585 967 900724 SGTC_880 0833-0487 87.2 µM 0.847279398084924 0.21193502604911 no 716 0.198419703536468 943 76075 SGTC_1268 0828-0275 2.46 µM 0.845809559753435 0.212341253466334 no 717 0.198829495800842 1017 745337 SGTC_1718 roemerine 11.9335 µM 0.844873856218273 0.212600095936295 no 718 0.199090636370948 956 235224 An aporphine alkaloid with mutagenic activity. SGTC_2418 pentamidine 31.67 µM 0.843464012526117 0.212990446987259 no 719 0.199484492216737 968 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_410 α-linolenic acid 100 µM 0.843406773073441 0.213006304013162 no 720 0.199500492608843 994 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3158 9100007 49.47 µM 0.840564029531486 0.213794694478718 no 721 0.200296108532578 960 19297233 SGTC_2168 5727979 200 µM 0.839762822822523 0.214017203224532 no 722 0.200520691037522 940 695210 SGTC_1522 st012842 45.6 µM 0.835146458718579 0.215301869256988 no 723 0.201817625622834 880 3491067 YOR116C RPO31 SGTC_2163 5671233 125 µM 0.834390829580184 0.215512575055303 no 724 0.202030391589393 1036 701023 SGTC_656 4090-1979 187 µM 0.831945747736166 0.21619520072629 no 725 0.202719783946266 1047 22330961 SGTC_675 1309-0189 238 µM 0.831654905973409 0.21627648208521 no 726 0.202801880408329 967 4246530 SGTC_482 fipronil 114 µM 0.831143979319286 0.216419313255769 no 727 0.202946148741841 996 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1483 3453-0561 55.9 µM 0.82788025293225 0.217332985562741 no 728 0.203869159636561 999 4546991 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.826379460806051 0.217753875206617 no 729 0.204294435423503 929 2374 Ca(2+)-ATPase inhibitor. SGTC_1042 0350-0096 82 µM 0.824596360467071 0.21825454745718 no 730 0.204800394187018 974 3122515 SGTC_35 0133-0054 64.071 µM 0.824493380602052 0.218283483159359 no 731 0.204829637701698 971 99677 SGTC_311 1315-0136 58 µM 0.823886672160069 0.218454003433002 no 732 0.205001977002294 1001 6759207 SGTC_408 cantharidin 100 µM 0.823885715847533 0.218454272272851 no 733 0.205002248716831 991 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_857 0438-0306 1.35 µM 0.823380781193611 0.218596246780641 no 734 0.205145744352614 1014 4686136 SGTC_3032 9089427 49.47 µM 0.823308573617976 0.218616554015613 no 735 0.205166269651225 1002 17173707 SGTC_1837 st055472 66.5 µM 0.822265149138345 0.218910121805237 no 736 0.205463003526489 1019 676091 SGTC_455 paf C-16 10 µM 0.822215015245155 0.218924232698617 no 737 0.205477267248343 961 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1510 1123-0200 71.5 µM 0.819581299973952 0.219666264538351 no 738 0.206227418802947 1062 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1118 chelidonine 707.474 nM 0.814429706111361 0.221121859406397 no 739 0.207699413264538 1090 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_20 0481-0013 4.944 µM 0.814327525913033 0.221150786367589 no 740 0.207728672436808 1043 182045 SGTC_2552 juarezic acid 87.02 µM 0.813994782069667 0.221245000329389 no 741 0.207823970094083 1156 1549512 SGTC_1383 3049-0032 20.7 µM 0.810863375258193 0.222132758976014 no 742 0.208722067441444 1055 712864 SGTC_322 k048-0136 19.3 µM 0.809486626591795 0.222523711877561 no 743 0.209117646092806 1001 6823282 SGTC_1675 st018485 24.5 µM 0.807789420900501 0.223006203923005 no 744 0.209605908101677 1022 3323024 SGTC_515 4092-1064 102 µM 0.806050896193446 0.223501059577246 no 745 0.210106751520412 1077 717353 SGTC_2782 7736369 71.43 µM 0.805971086624973 0.223523791649484 no 746 0.210129760349381 1055 2950836 YOL077C BRX1 SGTC_1578 josamycin 24.2 µM 0.805078835762286 0.223778020008617 no 747 0.210387094015054 954 5282165 A P450 substrate. SGTC_3016 9080866 49.47 µM 0.805057973564011 0.223783966224737 no 748 0.21039311308483 1070 17066299 SGTC_1488 4013-0813 75.9 µM 0.803871602315402 0.224122257619164 no 749 0.210735566010504 991 2910057 SGTC_304 1310-0298 97 µM 0.802483432168593 0.224518460073514 no 750 0.211136684189222 1026 1550234 SGTC_3242 9133940 49.47 µM 0.801195891734941 0.22488629643202 no 751 0.211509124601214 1098 17248444 SGTC_1226 3909-7979 35.4 µM 0.800298806536118 0.225142785764885 no 752 0.211768847200521 1060 6615510 SGTC_1349 flufenamic acid 69 µM 0.797544314381518 0.225931368793626 no 753 0.212567488486514 984 3371 A non-steroidal anti-inflammatory. SGTC_3075 9116269 49.47 µM 0.796760417412921 0.226156075640573 no 754 0.212795093812892 1037 17015205 YNL244C SUI1 SGTC_2667 digitoxin 100 µM 0.796659405538702 0.226185040235289 no 755 0.212824433062644 1006 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2227 7312221 64.1025 µM 0.795522148402353 0.226511287025102 no 756 0.213154916256056 1074 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_226 1,3-diallylurea 8.28947 mM 0.795503746980025 0.226516568054124 no 757 0.213160266108629 1017 74537 YKL182W FAS1 SGTC_2256 7954252 200 µM 0.794738841659061 0.226736149924937 no 758 0.213382716604016 926 2972920 SGTC_702 1488-0190 94 µM 0.794204968222433 0.226889480466992 no 759 0.213538058343269 1050 949357 SGTC_2047 4141938 200 µM 0.792775611914539 0.227300284979657 no 760 0.21395428397726 996 3807862 SGTC_3243 9134147 49.47 µM 0.792103239427154 0.227493673217557 no 761 0.214150240697897 1114 24282180 SGTC_2612 dictamnine 15.46 µM 0.790947937505194 0.227826178257818 no 762 0.214487186489122 996 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_422 cantharidin 155 µM 0.790773427786129 0.227876427300663 no 763 0.21453810933154 1034 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2212 7123476 200 µM 0.790452114738243 0.227968963804017 no 764 0.214631888529673 1000 1085715 SGTC_982 1491-0518 27.5 µM 0.789778351333655 0.228163072814028 no 765 0.21482861207825 992 3091256 SGTC_2846 9008642 19.48 µM 0.788680699830737 0.228479501509874 no 766 0.215149325515292 1006 2992898 SGTC_2259 7964009 200 µM 0.787591955555534 0.228793605850663 no 767 0.215467710814662 998 313134 SGTC_2907 7721985 69.9 µM 0.787449129832686 0.2288348292619 no 768 0.215509498108977 1064 3267881 SGTC_931 2812-0076 566 µM 0.7849928948466 0.229544417891047 no 769 0.216228867220391 1104 3450959 SGTC_2818 7996756 12.99 µM 0.784922528864734 0.22956476426599 no 770 0.21624949610164 1044 2241621 SGTC_2795 7780010 54.55 µM 0.78467868385062 0.229635280046678 no 771 0.216320991872947 1002 953673 SGTC_895 0964-0006 13.7 µM 0.784493242322466 0.229688914665824 no 772 0.216375372801795 1059 6738897 SGTC_1203 3992-3522 103 µM 0.784457855131068 0.229699150379336 no 773 0.21638575103294 1109 5322312 SGTC_524 r073-0010 27.8 µM 0.78384391309552 0.229876773223509 no 774 0.216565851649438 1004 2772106 SGTC_1269 0831-0796 3.05 µM 0.782812200387925 0.230175436635971 no 775 0.216868701018652 1078 927758 SGTC_624 k048-0052 28 µM 0.78175688316821 0.230481157596343 no 776 0.217178732417683 1018 6835531 SGTC_3130 9127414 49.47 µM 0.7812051554333 0.230641081106876 no 777 0.21734092101853 1094 1494646 SGTC_3013 9080133 71.4286 µM 0.780307823285985 0.230901313700219 no 778 0.217604854520842 1124 17050193 SGTC_2315 7733312 200 µM 0.779511986902662 0.231132248926514 no 779 0.217839089628037 1030 726316 SGTC_209 4077-0173 175.592 µM 0.778913820002235 0.231305909374972 no 780 0.21801524121241 991 15993494 SGTC_27 0485-0001 32.618 µM 0.77744665095052 0.231732167472062 no 781 0.218447649044999 1011 2054479 SGTC_1455 4262-0120 131 µM 0.777310543169944 0.231771733174569 no 782 0.21848778810002 1084 1529587 SGTC_974 1326-0144 138 µM 0.776595050729233 0.231979784349037 no 783 0.218698861231452 1087 5411856 SGTC_1381 2324-0066 62.1 µM 0.776317005542249 0.232060662487538 no 784 0.218780917328794 1027 10885928 SGTC_309 k408-0051 1.48 µM 0.77598673481789 0.232156752451047 no 785 0.218878409131258 1082 3640463 SGTC_62 0180-0423 3.232 µM 0.775097983036349 0.232415438525304 no 786 0.219140881670487 1084 30102 YGL099W LSG1 SGTC_1759 st043059 70 µM 0.773921011922937 0.232758262262739 no 787 0.219488751559341 1099 669426 SGTC_171 k064-0041 9.68 µM 0.773684644699086 0.232827144290743 no 788 0.219558651352227 1002 53325 SGTC_665 3914-0008 307 µM 0.770212132540204 0.233840406603012 no 789 0.220587034082582 1077 1069549 SGTC_63 0099-0242 26.702 µM 0.769943880857571 0.233918782700303 no 790 0.220666591345567 1119 3898502 YLR359W ADE13 SGTC_60 0986-0278 202 µM 0.768358950149898 0.234382154741972 no 791 0.22113698054779 951 3110598 SGTC_1987 st072290 61.9 µM 0.767319525342211 0.234686317675418 no 792 0.221445781119769 1084 54697379 SGTC_412 gemfibrozil 100 µM 0.767132949863738 0.234740937644409 no 793 0.221501236530294 1059 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1212 0520-0165 585 µM 0.765384274410685 0.23525320383414 no 794 0.222021377140999 1085 5403258 SGTC_2061 5245884 80.95 µM 0.765170351598726 0.235315913853422 no 795 0.222085055962914 1113 573863 SGTC_3035 9091303 49.47 µM 0.765004808312859 0.235364448076148 no 796 0.222134340711331 1099 25237002 SGTC_1826 st055655 41.6 µM 0.764061790021689 0.235641028918598 no 797 0.222415210604329 1062 676168 SGTC_75 0159-0059 199.013 µM 0.763193829044627 0.235895754315906 no 798 0.222673904241711 1061 5377270 SGTC_1240 0356-0016 42.1 µM 0.760749743942547 0.236613848507618 no 799 0.223403278510998 1059 4305613 SGTC_843 0310-0051 143 µM 0.760639121752997 0.236646378726275 no 800 0.223436322978494 1093 2065037 SGTC_2540 epiandrosterone 100 µM 0.760473638337358 0.236695046356026 no 801 0.22348576048835 1206 441302 A steroid. SGTC_2544 sphondin 68.51 µM 0.758773825019998 0.237195269318246 no 802 0.223993933020282 1104 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1820 st053765 18.6 µM 0.758053431072057 0.237407442737515 no 803 0.224209498357881 1101 3690829 SGTC_3304 9125678 46.087 µM 0.757777732019513 0.237488670329725 no 804 0.224292027653816 1059 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1344 1488-0097 29.1 µM 0.75572217814512 0.238094766707518 no 805 0.224907892023478 1073 747966 SGTC_2777 climbazole 1.536 µM 0.751680301147751 0.239289014549032 no 806 0.226121669746111 1104 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_10 0279-0212 42.575 µM 0.751562593655959 0.239323842389779 no 807 0.226157072752058 1159 39851 YBR002C RER2 SGTC_3193 9111931 49.47 µM 0.751245974526773 0.239417538872283 no 808 0.226252318162851 1145 17087244 SGTC_2243 6634756 200 µM 0.751171144378515 0.239439686138856 no 809 0.226274831888952 1088 885676 SGTC_2889 9059656 51.95 µM 0.751104192155274 0.239459502746602 no 810 0.226294976500738 1149 3949838 SGTC_2208 7283366 200 µM 0.75033290240929 0.23968785467997 no 811 0.226527115515958 1123 898663 SGTC_2198 6589944 200 µM 0.75028728926013 0.239701362859813 no 812 0.226540848147713 1035 5290268 SGTC_3266 9136860 49.47 µM 0.75013283366013 0.239747107448376 no 813 0.226587353182168 1074 4871271 YPR165W RHO1 SGTC_681 1642-0006 26.6 µM 0.749981513929763 0.239791927916067 no 814 0.226632919263181 1136 4446530 SGTC_1809 st050081 57.6 µM 0.749676688004588 0.239882230354354 no 815 0.226724725524493 1143 5036894 SGTC_1664 st014217 9.02 µM 0.74879005498597 0.240144994273633 no 816 0.226991877393215 1183 3982782 SGTC_783 0848-0141 92.7 µM 0.748781035256744 0.240147668180279 no 817 0.226994596044441 1069 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1050 3232-1156 69.3 µM 0.746350656671019 0.240868747016552 no 818 0.227727809107268 1072 700529 SGTC_2655 perillic acid 100 µM 0.743856756682603 0.241609895041702 no 819 0.228481569555211 1114 5702197 An apoptosis inducer. SGTC_3301 9125354 19.7965 µM 0.7435770565951 0.241693094678943 no 820 0.228566193897555 1076 41905162 SGTC_1588 farnesol 29.9 µM 0.741483818620056 0.242316243042378 no 821 0.229200069722745 1113 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_825 1988-2224 89.6 µM 0.740936366056429 0.242479360938121 no 822 0.229366012178609 1102 1180859 SGTC_1960 st011366 51.8 µM 0.73933253472845 0.242957577563089 no 823 0.229852548978934 1170 3972846 SGTC_2838 9002687 71.43 µM 0.739067580810456 0.243036628319686 no 824 0.229932980730586 1089 6457060 SGTC_645 0845-0943 5.41 µM 0.73806675216897 0.243335357655265 no 825 0.230236943217491 1098 1885106 SGTC_2784 7567673 72.73 µM 0.737900844096611 0.243384897395568 no 826 0.230287353001183 1169 3471247 SGTC_547 1120-0019 610 nM 0.736769230794888 0.243722939637818 no 827 0.23063134883898 1085 3676939 SGTC_2003 4023581 200 µM 0.733615351206151 0.244666421443033 no 828 0.231591601091952 1129 16641307 SGTC_346 4513-0042 7.16 µM 0.732626998651304 0.244962490930395 no 829 0.231892979784991 1116 2827372 SGTC_2813 7971799 71.43 µM 0.732086246810409 0.245124559332703 no 830 0.232057963837683 1120 2234054 SGTC_1399 3562-5772 25 µM 0.731157668474496 0.245402997457756 no 831 0.232341426624501 1073 23847490 SGTC_2920 7982904 15.77 µM 0.730885319875941 0.245484694556537 no 832 0.232424601731718 1087 6456808 SGTC_272 doxorubicin 8.13 µM 0.730350427556402 0.245645190083761 no 833 0.232588005734227 1163 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3134 9127454 49.47 µM 0.730041580701297 0.245737885866445 no 834 0.232682384291726 1212 24262820 SGTC_474 dl-dihydrosphingosine 5 µM 0.728068781926022 0.246330434900089 no 835 0.233285741359536 1182 3058739 A sphingolipid protein kinase C inhibitor. SGTC_472 calcifediol 10 µM 0.728048480535782 0.246336536596198 no 836 0.233291954808621 1103 5283731 A vitamin D metabolite. SGTC_456 gingerol 170 µM 0.727114663173898 0.246617288164183 no 837 0.233577858454899 1213 442793 A herb. SGTC_642 0335-0876 158 µM 0.727040034442296 0.246639732635949 no 838 0.233600715658102 1161 6812350 SGTC_1356 1502-0781 85.8 µM 0.726621512225423 0.246765622792544 no 839 0.233728923146196 1102 567702 SGTC_290 2043-6722 48.1 µM 0.726116136750023 0.246917683975577 no 840 0.233883788692275 1163 773758 YLR208W SEC13 SGTC_2875 9039966 71.43 µM 0.72579977603536 0.247012898487856 no 841 0.23398076212507 1182 6463691 SGTC_557 1315-0110 16.2 µM 0.725608628871765 0.247070437223035 no 842 0.234039364884969 1168 6833801 SGTC_2511 berberine 10.47 µM 0.72434651854134 0.247450535038195 no 843 0.234426512346677 1145 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_528 3492-0019 172 µM 0.723906267351796 0.247583194794059 no 844 0.234561641011298 1199 2869262 SGTC_701 4424-0219 185 µM 0.722752374981415 0.247931074412835 no 845 0.23491601575919 1200 2911779 SGTC_810 3825-7150 143 µM 0.721544787126808 0.248295421513325 no 846 0.235287197678689 1208 22330411 YGL099W LSG1 SGTC_2254 7938975 95.19 µM 0.721364080478306 0.248349967923849 no 847 0.235342770163768 1172 2969277 SGTC_1835 st008666 49.2 µM 0.721224108860063 0.248392222830727 no 848 0.23538582043607 1066 690455 SGTC_1090 efavirenz 20.7 µM 0.719401135992082 0.248942895228501 no 849 0.235946898560218 1162 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_3079 9117512 49.47 µM 0.718896514002902 0.249095443061208 no 850 0.236102342252437 1194 7185044 SGTC_823 0417-1665 178 µM 0.7178399018907 0.249415019173525 no 851 0.236428003574259 1182 3429856 SGTC_277 nystatin 15.5 µM 0.716176235802063 0.24991864227261 no 852 0.236941267433645 1173 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_682 0kpi-0099 17 µM 0.716092230645028 0.249944086524852 no 853 0.236967200414141 1190 1714895 YML126C ERG13 SGTC_2824 7998404 51.95 µM 0.716028459519703 0.249963403025967 no 854 0.236986888048962 1114 837851 SGTC_529 4076-0302 30.3 µM 0.715770470664308 0.250041556854433 no 855 0.237066544404877 1108 5816522 SGTC_770 0389-1121 67.2 µM 0.713544779824064 0.250716334326537 no 856 0.237754356884129 1212 6753108 SGTC_1509 1326-1131 80 µM 0.712962192234293 0.250893120389255 no 857 0.237934576417038 1138 768313 SGTC_31 0508-1974 57.237 µM 0.710366179584527 0.251681681183759 no 858 0.238738545104164 1147 6810525 SGTC_2017 5132927 60.65 µM 0.70928899134508 0.252009270062631 no 859 0.239072579271593 1176 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3333 9141820 12.094 µM 0.708283775384219 0.252315173925547 no 860 0.239384525260722 1129 1939433 SGTC_1408 3909-7976 48.8 µM 0.70827422564608 0.252318081007432 no 861 0.239387489871139 1214 24152374 SGTC_2830 7992007 71.43 µM 0.706547252051118 0.252844087574661 no 862 0.239923939257119 1101 1952075 SGTC_334 1502-1024 68.5 µM 0.706395241995746 0.252890414858314 no 863 0.239971189477936 1211 3296216 SGTC_2713 st079149 53.4 µM 0.706088607223612 0.252983879876174 no 864 0.240066518091118 1180 3103253 SGTC_2094 5332512 191.667 µM 0.702998077378912 0.253926914888238 no 865 0.241028473821936 1203 755774 SGTC_3291 9121177 71.43 µM 0.702189252339333 0.254174021568908 no 866 0.2412805736495 1122 17015612 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.701943829766671 0.254249026321167 no 867 0.241357096872445 1165 521171 SGTC_1229 0139-0193 12.2 µM 0.700463994308297 0.25470153166413 no 868 0.241818791706779 1219 3090752 SGTC_765 1319-0117 244 µM 0.69897394479829 0.25515758600166 no 869 0.24228415702512 1182 3487746 YGL099W LSG1 SGTC_74 000s-0487 160.283 µM 0.698382313781434 0.255338782845394 no 870 0.24246906699427 1166 677548 SGTC_2584 androsterone 48.74 µM 0.697937792251064 0.255474969198622 no 871 0.242608049243809 1258 2754130 A steroid. SGTC_3191 9110352 49.47 µM 0.696356143733204 0.255959840351512 no 872 0.243102910490499 1176 17122424 SGTC_3093 9117344 49.47 µM 0.696177638022148 0.256014593310455 no 873 0.243158795058064 1156 24824913 SGTC_680 0417-1641 114 µM 0.696018268551283 0.256063481783089 no 874 0.243208694534412 1176 2835990 SGTC_2878 9043973 25.97 µM 0.695574343858252 0.256199686609502 no 875 0.243347719030778 1210 6465167 SGTC_2284 7945075 39.21 µM 0.695538358408546 0.256210729308146 no 876 0.243358990524172 1266 1245402 SGTC_1259 0671-0132 43 µM 0.694003022804449 0.25668210213619 no 877 0.243840156623065 1147 X1259 SGTC_1917 st066507 28.5 µM 0.693829152943391 0.256735511440607 no 878 0.24389467886853 1179 3156428 SGTC_2222 6885208 172.143 µM 0.693632399769322 0.256795957012937 no 879 0.243956384814209 1165 609514 SGTC_2894 9048625 32.47 µM 0.692751279929406 0.25706674128823 no 880 0.244232825873303 1251 4092861 SGTC_2484 5809818 12.04 µM 0.691936601359899 0.257317239010691 no 881 0.244488571940843 1197 2870548 SGTC_2759 disulfiram 3.38 µM 0.690677200729368 0.257704729563104 no 882 0.244884210083879 1169 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3350 9150499 3.57 µM 0.688516932382803 0.258370102555369 no 883 0.245563655591255 1201 4910996 YPR165W RHO1 SGTC_2443 5493264 126.67 µM 0.687227359867803 0.258767720924249 no 884 0.245969732854193 1203 5340055 SGTC_1011 4112-3381 17.4 µM 0.684167110912949 0.259712564009789 no 885 0.246934823914765 1256 2877139 SGTC_167 3672-0051 66.205 µM 0.683302164482234 0.259979936123121 no 886 0.247207963372243 1190 3237971 SGTC_358 0075-0058 9.45 µM 0.683202452842847 0.260010768093429 no 887 0.247239461465806 1217 1069125 SGTC_1780 st038448 24.544 µM 0.681351269868252 0.260583517127989 no 888 0.247824624612826 1247 728868 YDL195W SEC31 SGTC_3274 9138298 49.47 µM 0.680144781713324 0.260957149300673 no 889 0.248206395846407 1205 17015756 SGTC_3184 9108758 49.47 µM 0.679720129845305 0.261088723443441 no 890 0.24834084379028 1225 902885 SGTC_2698 st077697 67.5 µM 0.678618147307057 0.261430320730198 no 891 0.248689920684153 1170 3154499 SGTC_812 4251-0442 148 µM 0.678422489244678 0.261490995641248 no 892 0.248751926929462 1217 5723007 SGTC_413 propylparaben 100 µM 0.677905550414833 0.261651336706693 no 893 0.248915790270137 1199 7175 A pharmaceutical preservative. SGTC_1942 st076330 65.2 µM 0.676881939565297 0.261968983142251 no 894 0.249240431934842 1264 24208414 SGTC_1233 0325-0408 14.2 µM 0.674883007552433 0.262589860314088 no 895 0.249875048600627 1249 12874 SGTC_3051 9093778 49.47 µM 0.673141324432687 0.263131448097211 no 896 0.250428692906138 1243 17217378 SGTC_3019 9081971 49.47 µM 0.672273728974328 0.263401445392934 no 897 0.250704725591963 1276 16451803 SGTC_936 3005-4620 401 µM 0.671740879541966 0.263567339192587 no 898 0.250874335890699 1254 777207 SGTC_1005 4092-0690 4.4 µM 0.670888600361894 0.263832792916785 no 899 0.251145749491444 1223 1529343 SGTC_688 0527-0193 473 µM 0.67073412663503 0.263880920408814 no 900 0.251194959230528 1237 4007154 SGTC_617 3770-0098 35 µM 0.670731053348408 0.263881877960589 no 901 0.251195938320159 1202 5962639 SGTC_2656 pseudo-anisatin 100 µM 0.669637912652265 0.264222582935849 no 902 0.251544319778246 1261 6708809 A neurotoxin. SGTC_499 genistein 192 µM 0.665925667687273 0.26538126785979 no 903 0.252729306648392 1246 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1338 1486-1223 76 µM 0.665897693801506 0.265390008991633 no 904 0.252738247346795 1254 3444526 SGTC_1904 st060225 78 µM 0.665778957441056 0.265427112727677 no 905 0.252776198379112 1228 66595 SGTC_2090 5301565 104.445 µM 0.664773982413075 0.265741261162028 no 906 0.253097533003912 1270 2056344 SGTC_509 pifithrin 175 µM 0.664372576456735 0.265866790622809 no 907 0.253225940133531 1276 4817 A p53 inhibitor. SGTC_324 1315-0088 19.6 µM 0.663223388035849 0.266226336035274 no 908 0.25359374730367 1195 6787421 SGTC_2826 7992541 19.48 µM 0.662977799369893 0.266303205020263 no 909 0.253672386347232 1311 2985066 SGTC_2438 5259590 200 µM 0.661436885475169 0.26678576559386 no 910 0.254166088836141 1252 1201127 SGTC_3252 9135871 49.47 µM 0.661121025649431 0.266884736439235 no 911 0.254267351225411 1276 17682838 SGTC_2009 4012297 12.05 µM 0.660279083385421 0.267148639423148 no 912 0.254537375162503 1239 45595307 SGTC_980 1473-0395 201 µM 0.660144492211262 0.267190838625186 no 913 0.254580554561575 1200 768876 SGTC_253 dyclonine 31.25 µM 0.660095372766178 0.267206240186112 no 914 0.254596313965957 1311 3180 An oral anasthetic. SGTC_2412 st077135 33.4 µM 0.656378718091912 0.268372907383757 no 915 0.255790240064694 1320 13258915 SGTC_234 nsc-17383 10.7 µM 0.655247702890573 0.268728443611221 no 916 0.256154142890359 1286 408974 SGTC_9 0092-0002 10.449 µM 0.653668894080605 0.269225139769621 no 917 0.256662573883274 1238 759368 SGTC_361 000s-0510 1.45 µM 0.653235480173619 0.269361573098842 no 918 0.256802240009058 1257 660 SGTC_508 roscovitine 141 µM 0.652618463519025 0.269555862085 no 919 0.257001139705329 1304 160355 A CDKinase inhibitor. SGTC_2849 9019321 12.99 µM 0.650542923925943 0.270209932336226 no 920 0.257670792329809 1248 16489627 SGTC_2662 daunorubicin 22.37 µM 0.646365401405218 0.271528807834232 no 921 0.259021370827263 1233 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_230 MPP+ 141.667 µM 0.645990181320064 0.271647424386644 no 922 0.259142857108152 1238 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_600 1495-0418 41.6 µM 0.645363379548287 0.271845629794359 no 923 0.259345864530575 1281 5377768 SGTC_1691 st019933 84.6 µM 0.644640686109148 0.272074247057705 no 924 0.259580031115367 1255 6176082 SGTC_2432 5630864 12.22 µM 0.643505394191084 0.272433578893796 no 925 0.25994810786979 1259 5714970 SGTC_67 0335-0847 266 µM 0.642873673826907 0.272633627048035 no 926 0.260153036526641 1374 4552207 YOR254C SEC63 SGTC_900 1112-0045 141 µM 0.64263091300687 0.272710521991452 no 927 0.260231809730694 1202 56211 YIL048W NEO1 SGTC_2903 5923464 63.88 µM 0.642549080878703 0.272736444896049 no 928 0.260258366122001 1307 2876576 SGTC_198 3454-2873 16.191 µM 0.641622638197047 0.273030010048467 no 929 0.260559115262991 1272 710957 SGTC_1351 1496-0003 46.5 µM 0.640196187934105 0.273482320407923 no 930 0.261022530402753 1271 3891978 SGTC_483 fpl-64176 144 µM 0.639921156201824 0.273569572322692 no 931 0.261111929483014 1299 3423 SGTC_1306 1185-0270 9.02 µM 0.639515101865098 0.273698415430589 no 932 0.261243946232605 1267 1548076 SGTC_2638 epoxomicin 18 µM 0.637583198093096 0.274311829174561 no 933 0.261872517913518 1291 9915668 A protesome inhibitor. SGTC_1739 st037196 92.5 µM 0.636698312650651 0.274593022487647 no 934 0.262160686439714 1300 612214 SGTC_2442 5158906 48.48 µM 0.6355394234461 0.274961501904024 no 935 0.262538331616633 1325 1893835 SGTC_1631 benzylvanillin 81.9 µM 0.634882396222871 0.275170517877652 no 936 0.262752559529001 1306 75506 SGTC_1029 k015-0030 64.7 µM 0.63323413636189 0.275695212567152 no 937 0.263290378402572 1328 2208316 SGTC_1762 st045503 25.4615 µM 0.63138902515564 0.276283154250558 no 938 0.263893095087128 1298 4645554 SGTC_2381 9035592 200 µM 0.627439924705151 0.277543592333073 no 939 0.265185451983395 1239 4749657 SGTC_2318 6029776 164 µM 0.625826705794846 0.27805929210282 no 940 0.265714306580411 1367 818325 SGTC_966 1300-0360 30.2 µM 0.625323778394342 0.27822015908559 no 941 0.265879288368948 1306 70588 SGTC_1838 st055369 84.5 µM 0.625273831723905 0.278236137566456 no 942 0.265895675855261 1266 676036 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.624722691320409 0.278412483053882 no 943 0.266076538819001 1245 1241132 A phosphatase inhibitor. SGTC_2989 9073649 71.4286 µM 0.623222539222026 0.278892754506598 no 944 0.266569146105798 1296 21367202 SGTC_2743 auranofin 4.32 µM 0.622149844307428 0.279236423172 no 945 0.266921671184007 1257 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3124 9127567 49.47 µM 0.621240793040586 0.27952782491207 no 946 0.267220601474126 1289 17592030 SGTC_1678 st019265 80.2 µM 0.616303973334868 0.281112924745271 no 947 0.26884695848128 1354 5367020 SGTC_1494 4358-1428 177 µM 0.615935686039844 0.281231347180447 no 948 0.268968483841563 1388 1564571 SGTC_1247 0448-0043 5.84 µM 0.614928836875701 0.281555221476741 no 949 0.269300858924963 1356 3089013 YGL099W LSG1 SGTC_259 usnic acid 108.925 µM 0.614577232412637 0.28166836484468 no 950 0.26941697701329 1374 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2270 7924575 90.91 µM 0.614362370052771 0.281737516540274 no 951 0.269487948097804 1332 1262135 SGTC_1282 0886-0010 32.4 µM 0.613357247678587 0.282061115610408 no 952 0.269820073988714 1370 2836211 YNL267W PIK1 SGTC_335 4077-0256 27.6 µM 0.613350699380254 0.282063224421228 no 953 0.269822238436226 1325 3121989 SGTC_2360 9040895 200 µM 0.613084873866473 0.282148837149852 no 954 0.269910110643446 1278 4914414 SGTC_1875 nocodazole 6 µM 0.612395421296189 0.282370943022934 no 955 0.270138085220024 1314 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_3095 9117207 49.47 µM 0.611814224242475 0.282558239891294 no 956 0.270330338787246 1291 17015229 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.611675036666587 0.282603103415529 no 957 0.270376390649886 1270 2333 A French combination drug. SGTC_608 k048-0125 159 µM 0.611135083661948 0.282777175734556 no 958 0.270555077617868 1360 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2788 5282734 71.43 µM 0.60923099453218 0.283391434746461 no 959 0.271185669407744 1411 743706 SGTC_2457 5731572 11.68 µM 0.606104230881199 0.284401514021873 no 960 0.272222770840793 1370 2865357 SGTC_2279 7948423 32.93 µM 0.6046232068101 0.28488054818735 no 961 0.27271469170589 1429 1247112 SGTC_2664 lyso-paf C-16 73.48 µM 0.603700962080881 0.285179040676944 no 962 0.273021237193284 1342 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1906 st060206 94.7 µM 0.603364106362895 0.285288104097367 no 963 0.273133247445639 1320 5133468 SGTC_275 trichlorophene 5.69 µM 0.603202011794534 0.285340592365238 no 964 0.273187154759488 1371 62616 SGTC_2031 5180455 200 µM 0.602250211895801 0.285648889955751 no 965 0.273503798369283 1293 29949 SGTC_3328 9140624 29.0385 µM 0.598929992480769 0.286725581499729 no 966 0.274609784991451 1369 4904392 SGTC_3031 9088762 49.47 µM 0.597586758722543 0.287161715701315 no 967 0.275057850799534 1300 205253 SGTC_1000 4048-0884 8.67 µM 0.597345877607859 0.287239960521317 no 968 0.275138240171365 1348 13040088 SGTC_403 arphamenine a 50 µM 0.59644338124207 0.287533205881683 no 969 0.275439533561779 1312 5487158 An arginine aminopeptidase inhibitor. SGTC_223 busulfan 5 mM 0.595339317982699 0.28789213812886 no 970 0.275808339542818 1368 2478 A DNA alkylator. SGTC_2931 9014674 55.67 µM 0.595011067006363 0.287998893692751 no 971 0.275918036671928 1320 2996810 SGTC_695 3505-6186 243 µM 0.595001969881867 0.288001852575053 no 972 0.275921077115639 1361 1819379 SGTC_1822 st052468 42 µM 0.594101665063956 0.288294751887728 no 973 0.276222058647126 1325 2873678 SGTC_1670 st016595 4.04 µM 0.593417571976506 0.288517404161633 no 974 0.276450865958204 1342 597879 SGTC_220 paclitaxel 373.376 µM 0.592143973991943 0.288932138736846 no 975 0.27687709128099 1360 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_959 1222-0044 107 µM 0.588823812419977 0.290014633304683 no 976 0.277989735099273 1356 6083612 SGTC_2695 st077686 51.995 µM 0.588686921899638 0.290059305421747 no 977 0.278035656282088 1315 2876092 SGTC_2884 9058502 51.95 µM 0.588325058055019 0.290177409654474 no 978 0.278157064653601 1348 6471554 SGTC_607 4491-0986 66.8 µM 0.587308873546793 0.29050918987869 no 979 0.278498141313201 1416 698981 YDR232W HEM1 SGTC_1032 k061-1018 98.7 µM 0.585458985093893 0.291113626484239 no 980 0.27911956861844 1504 4005393 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.584564542231368 0.291406089196744 no 981 0.279420277638833 1421 1273210 SGTC_504 lovastatin 124 µM 0.583957690721028 0.291604594021477 no 982 0.279624388863239 1318 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1984 st072354 53.1 µM 0.583760573139721 0.291669085944859 no 983 0.279690703864362 1318 5762938 SGTC_2723 salbutamol 83.58 µM 0.579931274290261 0.292923253375751 no 984 0.280980482291348 1373 9884233 β2-adrenoceptor agonist SGTC_2822 7994718 71.43 µM 0.578365042826364 0.293436943839038 no 985 0.281508844883472 1376 1018011 SGTC_1617 st002906 78 µM 0.578313002350463 0.293454019164541 no 986 0.281526408776332 1365 5150859 SGTC_2010 4012422 159 µM 0.57830218792578 0.293457567610713 no 987 0.281530058759264 1403 952393 SGTC_667 1498-1044 59 µM 0.577649483644315 0.293671770764786 no 988 0.281750395625815 1405 6739982 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.576967616800192 0.293895621690841 no 989 0.281980665795037 1399 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1054 3429-0080 167 µM 0.574065179118562 0.294849348335284 no 990 0.282961847741381 1424 1162877 SGTC_1184 1269-1718 139 µM 0.573891047608988 0.294906612421083 no 991 0.283020765753038 1471 5403821 SGTC_2034 5197015 53.07 µM 0.573539501102654 0.29502223600096 no 992 0.283139730697579 1463 780676 SGTC_1616 st002734 56.1 µM 0.570739949554792 0.295943752380426 no 993 0.284087967095762 1391 4026101 SGTC_2930 9013230 14.89 µM 0.570405724192473 0.296053856162559 no 994 0.284201274020581 1418 2995857 SGTC_2335 9018011 154.17 µM 0.568973249943048 0.29652596864595 no 995 0.284687146803293 1447 6458208 SGTC_2962 9082311 13.18 µM 0.568171962639096 0.296790205945479 no 996 0.284959103706248 1341 16459453 SGTC_2523 spermine 47.74 µM 0.567646571825319 0.29696352045192 no 997 0.285137488572113 1379 1103 A DNA binding polyamine. SGTC_961 1252-1571 372 µM 0.567586839685311 0.296983227660261 no 998 0.285157772672327 1470 6813498 SGTC_488 nitrendipine 139 µM 0.567580684457638 0.296985258466206 no 999 0.285159862930429 1429 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2152 5568786 200 µM 0.56754360197643 0.296997493294006 no 1000 0.285172455950868 1367 5399883 SGTC_589 1227-0070 34.1 µM 0.567535844400992 0.297000052822869 no 1001 0.285175090417223 1387 2841384 SGTC_1797 st048695 56.8 µM 0.567438310245774 0.297032234032786 no 1002 0.285208213927206 1381 592262 YIL048W NEO1 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.566037120837297 0.29749472974765 no 1003 0.285684273178769 1349 5355888 SGTC_867 0518-0118 155 µM 0.564442215382159 0.298021565801775 no 1004 0.286226607798845 1418 6848158 SGTC_1954 st077032 68.9 µM 0.563761100103343 0.298246684230458 no 1005 0.286458364399084 1309 698907 SGTC_3327 9140648 26.9345 µM 0.56367128787387 0.298276374245929 no 1006 0.286488930593622 1402 8029710 SGTC_2246 7293507 91.5585 µM 0.563659063342857 0.298280415520284 no 1007 0.28649309114215 1441 887656 SGTC_2056 5235370 200 µM 0.562507155841872 0.298661333276156 no 1008 0.286885264773418 1371 5511916 SGTC_1963 st076565 50.3 µM 0.562397260186774 0.298697685601192 no 1009 0.286922692678406 1405 4914280 SGTC_2049 5262831 67.185 µM 0.561765936205178 0.298906559883576 no 1010 0.287137751755209 1408 763417 SGTC_2855 9016525 58.44 µM 0.560606823851962 0.29929022621072 no 1011 0.287532799302407 1357 43811474 SGTC_266 formosanin C 406 nM 0.55959115112901 0.299626597529418 no 1012 0.287879170994329 1400 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2043 5101342 149 µM 0.559218483876394 0.299750060713317 no 1013 0.288006309937005 1366 678451 SGTC_2133 5320837 200 µM 0.558274831750708 0.300062791907957 no 1014 0.288328364220871 1442 2841355 SGTC_82 0054-0107 293.755 µM 0.558255151784789 0.300069315521334 no 1015 0.288335082504611 1422 3104697 SGTC_3143 9086658 49.47 µM 0.556699986148991 0.300585032304589 no 1016 0.288866213196227 1443 25236626 SGTC_1214 0358-0031 63.7 µM 0.555004884080111 0.301147609515037 no 1017 0.289445659880103 1600 4301366 SGTC_1194 1488-0194 225 µM 0.554946373498824 0.301167036707071 no 1018 0.289465670639665 1410 1391452 SGTC_1039 k821-0043 94 µM 0.554222598019291 0.301407397612212 no 1019 0.289713257311245 1440 15992768 SGTC_1825 st052143 62.6 µM 0.551416970992257 0.302339942239783 no 1020 0.290673934762523 1459 674173 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.55006588186126 0.302789483442491 no 1021 0.291137093418224 1371 61125 An anti-inflammatory. SGTC_2194 5927483 104.545 µM 0.548776227071979 0.303218862909701 no 1022 0.291579513360737 1426 760979 SGTC_183 3914-0051 30.55 µM 0.547604241030888 0.303609301527927 no 1023 0.291981838360913 1497 1596232 SGTC_2765 myclobutanil 7.74 µM 0.547463320661519 0.303656263236656 no 1024 0.292030231585702 1410 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3072 9116419 49.47 µM 0.545154006803191 0.304426303465856 no 1025 0.29282380056073 1371 17170162 SGTC_2245 6637752 200 µM 0.545018102357585 0.304471647844629 no 1026 0.292870533726283 1491 681890 SGTC_1002 4049-0206 172 µM 0.54361278924926 0.304940705236751 no 1027 0.293353978538664 1405 4662749 SGTC_1173 0443-0020 122 µM 0.543088702345669 0.305115714117433 no 1028 0.293534365433394 1411 5331295 SGTC_1728 st035614 33.7865 µM 0.542158716665422 0.305426374903899 no 1029 0.29385458611392 1469 15945546 SGTC_760 0568-0725 82.9 µM 0.541450709676077 0.305662977923068 no 1030 0.294098481464941 1459 3916171 SGTC_1737 st035557 69.7 µM 0.540863610525962 0.305859237310144 no 1031 0.294300797223101 1386 5716916 SGTC_1053 3366-3204 134 µM 0.539918524783558 0.306175283941804 no 1032 0.294626610955 1367 3632071 YPR165W RHO1 SGTC_1628 st004252 77.7 µM 0.538603146754599 0.306615400384893 no 1033 0.295080357907345 1520 692968 SGTC_3181 9108277 49.47 µM 0.53768796134686 0.306921779773579 no 1034 0.295396245932334 1366 17097298 SGTC_981 1488-1094 54.9 µM 0.537517243372089 0.306978946481685 no 1035 0.295455188651547 1384 3449522 SGTC_628 1636-0253 16 µM 0.5374867180242 0.30698916870989 no 1036 0.295465728516117 1475 4456143 SGTC_1648 st011736 69.8 µM 0.533679916719591 0.308265151848216 no 1037 0.296781503160247 1490 2855514 SGTC_2082 5219693 150 µM 0.533299451563467 0.308392805887409 no 1038 0.296913153628156 1409 2834649 SGTC_881 0833-0569 170 µM 0.53158766862728 0.308967431425271 no 1039 0.297505803664011 1384 5418700 SGTC_1274 0865-0114 173 µM 0.52980693141342 0.309565700633485 no 1040 0.298122899465933 1453 870624 SGTC_1340 1486-1359 257 µM 0.529724338246709 0.309593461490071 no 1041 0.298151535406793 1458 4309068 SGTC_274 sirtinol 40.1 µM 0.528989685822981 0.309840437464341 no 1042 0.298406302437371 1392 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_444 curcumin 90.4 µM 0.526991687098944 0.310512560110918 no 1043 0.299099680631445 1440 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2507 purpurin 79.67 µM 0.525334280032391 0.31107058900753 no 1044 0.299675415520929 1377 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_947 3447-0010 211 µM 0.523448224184317 0.311706129884584 no 1045 0.300331186323364 1437 748350 SGTC_448 monastrol 171 µM 0.522839321643895 0.31191143062665 no 1046 0.30054303664065 1467 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2451 5856223 45.7 µM 0.522299075565813 0.312093631739819 no 1047 0.300731056371791 1411 2179896 SGTC_1572 epiandrosterone 68.9 µM 0.522186158578131 0.31213171945719 no 1048 0.300770361135179 1439 441302 A steroid. SGTC_1172 0370-0043 85 µM 0.521674430167084 0.312304354323018 no 1049 0.300948515408664 1490 376585 SGTC_2021 4019055 173 µM 0.520987210402098 0.312536257157013 no 1050 0.301187840459262 1441 44827708 YER133W GLC7 SGTC_2764 methyldopa 94.69 µM 0.518663404090651 0.313320976982026 no 1051 0.301997742982962 1553 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2779 methotrexate 400 µM 0.518110663616274 0.313507755078692 no 1052 0.3021905302785 1466 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_784 4579-0127 173 µM 0.517777210554644 0.313620456279159 no 1053 0.302306860235842 1576 1948547 SGTC_211 3455-0679 143.504 µM 0.517103174707798 0.313848321520374 no 1054 0.302542068786732 1463 748649 SGTC_832 4083-0019 164 µM 0.515645074437296 0.314341491262662 no 1055 0.303051161407634 1581 1990758 SGTC_2343 7990716 14.84 µM 0.515106400183763 0.314523769679924 no 1056 0.303239335285463 1497 6456862 SGTC_2944 9067346 25.62 µM 0.51454064080014 0.314715261944275 no 1057 0.303437026976055 1483 6473075 SGTC_3244 9134489 49.47 µM 0.514511373832704 0.314725169274694 no 1058 0.303447255215312 1408 16584271 SGTC_1726 st035556 14.5795 µM 0.514313546061703 0.314792140594936 no 1059 0.303516396235159 1546 5919439 SGTC_2247 cerulenin 830 nM 0.514022533031814 0.314890669314937 no 1060 0.303618118389573 1516 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2508 celastrol 40.54 µM 0.513473603063919 0.315076557225587 no 1061 0.303810035543546 1418 122724 Celastrol is a natural product and antioxidant. SGTC_1376 2910-0861 41.3 µM 0.512163575793658 0.315520369945393 no 1062 0.304268266438362 1502 1112859 SGTC_120 rhodamine 6G 52.259 µM 0.51212440164006 0.315533645518226 no 1063 0.304281973798384 1440 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_148 3253-0744 288.01 µM 0.51174083844898 0.315663642295441 no 1064 0.304416200253944 1419 6893655 SGTC_1690 st023502 41.2 µM 0.511570596268439 0.315721347881274 no 1065 0.304475784290433 1534 24207482 SGTC_1976 st070609 63.5 µM 0.51110917899559 0.315877773269358 no 1066 0.304637304456261 1431 682556 SGTC_3206 9114350 49.47 µM 0.51053270847085 0.316073249276463 no 1067 0.304839152801389 1420 17087243 SGTC_1863 st057641 20.1 µM 0.508618011835095 0.316722874652883 no 1068 0.305510000613852 1461 3921635 SGTC_1167 k781-0610 148 µM 0.508419081258067 0.316790401026138 no 1069 0.305579736971631 1479 4525169 SGTC_1886 st057356 49.9 µM 0.508375132114164 0.316805320251407 no 1070 0.305595144570223 1414 24207747 SGTC_1249 0481-0015 10.2 µM 0.50682384492273 0.317332119697073 no 1071 0.306139211941451 1419 4227577 SGTC_337 1315-0038 354 µM 0.506240501928154 0.317530312183258 no 1072 0.306343912736195 1453 1626437 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.505742109001126 0.317699684080711 no 1073 0.306518851612474 1423 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_279 1273-0055 2.93 µM 0.502498637840689 0.318802863488125 no 1074 0.307658405166632 1521 2847562 SGTC_2732 terfenadine 20 µM 0.500991664238565 0.319315967576148 no 1075 0.308188494729775 1484 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1156 4092-0367 4.88 µM 0.499598939370358 0.319790479429756 no 1076 0.308678752422169 1490 1357585 SGTC_3178 9107506 49.47 µM 0.496645913868634 0.320797572888437 no 1077 0.309719384667088 1495 8897194 SGTC_1341 1486-1360 280 µM 0.496414253452559 0.320876633798056 no 1078 0.309801085400497 1457 3976547 SGTC_2642 cholecalciferol 100 µM 0.494229750966332 0.321622558383287 no 1079 0.310571965432021 1520 9821465 A vitamin D precursor, similar to steriods. SGTC_1208 2323-2347 50.3 µM 0.493655384700253 0.321818802250124 no 1080 0.310774789534522 1540 5412760 SGTC_1404 3909-7820 48.3 µM 0.491704143557005 0.322485854354658 no 1081 0.311464254306967 1555 23741373 SGTC_2618 avocadyne 43.43 µM 0.489988788147608 0.323072738937054 no 1082 0.312070916320359 1517 3015189 SGTC_1668 st014914 51.6 µM 0.487862192083317 0.32380093551329 no 1083 0.31282372803116 1494 2839556 SGTC_125 0133-0007 11.75 µM 0.48510906960416 0.324744671882366 no 1084 0.313799489426665 1642 26541 SGTC_1336 1486-0901 104 µM 0.484351510187776 0.325004551712224 no 1085 0.314068212583607 1535 5006114 SGTC_244 nsc-207895 1.295 µM 0.483543498460575 0.325281833013311 no 1086 0.314354940983188 1415 42640 SGTC_1245 0418-0076 17.2 µM 0.483109126800029 0.325430934140916 no 1087 0.314509127008018 1537 6790114 SGTC_1568 digitonin 820 nM 0.482573431440665 0.325614853820475 no 1088 0.314699323793133 1656 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2240 6690706 185.951 µM 0.482001590085808 0.325811230320289 no 1089 0.314902408351518 1426 805876 SGTC_1123 mangostin 811.285 nM 0.479777012394905 0.326575633719802 no 1090 0.315692980105577 1485 5281650 An antioxidant. SGTC_2603 homopterocarpin 100 µM 0.479209807966617 0.326770651693943 no 1091 0.315894688744325 1518 101795 A weak amylase inhibitor. SGTC_1456 k015-0012 13 µM 0.47800890857194 0.327183704773501 no 1092 0.316321932203251 1679 2989616 SGTC_2271 7849410 118.62 µM 0.477916749390563 0.327215411964784 no 1093 0.316354729777206 1534 972430 SGTC_561 1550-0330 72.9 µM 0.474916249807548 0.328248408187259 no 1094 0.317423334327531 1491 6812934 SGTC_1874 staurosporine 7.6 µM 0.474241886365521 0.32848075570994 no 1095 0.317663713606087 1582 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1100 amiodarone 5.07 µM 0.473527863956506 0.328726839782122 no 1096 0.317918313268428 1575 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2954 9074818 52.69 µM 0.470970113699099 0.32960896400099 no 1097 0.318831038648367 1565 16648742 SGTC_2917 7979103 53.79 µM 0.470496083299497 0.329772553326451 no 1098 0.319000315929693 1622 2980565 SGTC_764 1951-2361 146 µM 0.469600968589685 0.33008154891814 no 1099 0.319320066271635 1479 5438930 SGTC_749 1000-0129 128 µM 0.469121631761506 0.330247064742686 no 1100 0.3194913488992 1657 708470 SGTC_1171 0368-0077 21.4 µM 0.467581999813935 0.330778926879927 no 1101 0.32004176984956 1493 3239779 SGTC_3209 9113616 49.47 µM 0.467008214560658 0.33097722709533 no 1102 0.320247000465074 1705 16649353 SGTC_3098 9119039 49.47 µM 0.466470237688666 0.331163195014771 no 1103 0.320439473155383 1521 17161528 SGTC_2589 lobaric acid 100 µM 0.464122250371135 0.331975334706208 no 1104 0.321280080591728 1487 73157 A novel microtubule depolymerizer. SGTC_3050 9093513 49.47 µM 0.463791241893806 0.332089890057923 no 1105 0.321398659368001 1504 25236664 SGTC_3205 9113483 49.47 µM 0.463138698918854 0.332315767966522 no 1106 0.321632476322261 1659 17018033 SGTC_632 0781-2353 4.65 µM 0.460824724728794 0.333117241272691 no 1107 0.3224621807234 1568 6811515 YHR007C ERG11 SGTC_1909 st060837 51.5 µM 0.460743204995095 0.333145490561727 no 1108 0.322491426806618 1495 678937 SGTC_2957 9076800 11.52 µM 0.459730938577208 0.333496353242229 no 1109 0.322854679757511 1498 16459615 SGTC_296 1222-0039 74.9 µM 0.458278673215748 0.333999978814026 no 1110 0.323376122057555 1484 5984176 SGTC_1860 st056228 74.6 µM 0.457730901846729 0.334190016094188 no 1111 0.323572892002521 1510 688679 SGTC_2699 st077704 54.6 µM 0.457466780143753 0.334281662529061 no 1112 0.323667787200919 1553 645852 SGTC_3140 9094243 49.47 µM 0.457300249245152 0.334339451436026 no 1113 0.323727625295754 1528 19291112 SGTC_1932 st074806 40.9 µM 0.456486859491597 0.334621767196241 no 1114 0.324019959002575 1618 17251235 SGTC_3351 9150312 21.596 µM 0.45414127506997 0.335436408708561 no 1115 0.324863573560438 1531 4904905 SGTC_2952 9073731 13.78 µM 0.453603879756134 0.335623159855031 no 1116 0.325056980269994 1493 16457353 SGTC_1394 3474-0001 65.7 µM 0.453156658714098 0.335778605351874 no 1117 0.325217969521109 1496 5017666 YIL048W NEO1 SGTC_1689 st020265 53.493 µM 0.453062879577104 0.335811204754722 no 1118 0.325251731984885 1635 5758320 YPR016C TIF6 SGTC_2601 securinine 100 µM 0.452941927944654 0.335853251655528 no 1119 0.325295279237314 1516 442872 A GABA receptor antagonist. SGTC_377 3970-0964 33.1 µM 0.450582372013996 0.336673923999109 no 1120 0.326145286996097 1597 16481235 SGTC_785 1270-0111 65.3 µM 0.450576939044282 0.336675814528942 no 1121 0.326147245216978 1515 6741994 SGTC_360 0957-0399 1.01 µM 0.450469261199556 0.33671328442381 no 1122 0.326186056840795 1649 6752301 YPR165W RHO1 SGTC_2377 9073351 62.6 µM 0.444694971879022 0.33872499601768 no 1123 0.328270101738728 1524 7337946 YHR072W ERG7 SGTC_493 zm226600 134 µM 0.443366384749835 0.339188518475479 no 1124 0.328750373029711 1579 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1445 4239-0156 97.7 µM 0.442734251088535 0.33940914516674 no 1125 0.328978982578792 1703 4008346 SGTC_1841 st054148 70 µM 0.441919805700128 0.339693483282403 no 1126 0.329273619028099 1511 675442 SGTC_2717 st081029 62.2815 µM 0.441656893877086 0.339785290207042 no 1127 0.329368753529435 1608 5292846 SGTC_3081 9117243 49.47 µM 0.439428389827365 0.340563849092666 no 1128 0.33017557966528 1681 45595589 SGTC_2441 5730946 39.09 µM 0.437522982715815 0.341230068910848 no 1129 0.330866056105552 1657 1774275 SGTC_527 4476-4215 268 µM 0.437448431651722 0.34125614554404 no 1130 0.330893083444552 1589 4418754 SGTC_2515 chrysin 20.77 µM 0.4367960623229 0.341484365033513 no 1131 0.331129627478308 1650 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1132 3456-3614 2.5 µM 0.436061952220351 0.341741249359835 no 1132 0.331395890688161 1778 3125502 SGTC_1222 0366-0074 1.18 µM 0.435654136987881 0.341883986256441 no 1133 0.331543842933326 1697 286520 SGTC_750 4073-0104 132 µM 0.435546459087684 0.341921677707727 no 1134 0.331582912039134 1485 22330957 SGTC_629 3448-6466 76.7 µM 0.432951257303334 0.342830575051786 no 1135 0.332525090546739 1582 573744 SGTC_5 0352-0601 109.883 µM 0.432241455234528 0.343079322289629 no 1136 0.332782966276385 1587 762456 SGTC_2985 9022375 71.43 µM 0.430110263501597 0.34382659807378 no 1137 0.333557717211108 1577 4939335 SGTC_2775 cyproheptadine 69.59 µM 0.429157451731565 0.344160887310155 no 1138 0.333904322342187 1593 2913 A selective serotonin reuptake inhibitor. SGTC_1777 st045864 34.765 µM 0.428249150635179 0.344479673620784 no 1139 0.334234867771478 1588 4691462 SGTC_1531 st059297 52.4 µM 0.427578909673333 0.344714978866255 no 1140 0.334478861747164 1598 7566702 SGTC_2162 5663267 200 µM 0.42733091183385 0.344802060090383 no 1141 0.334569160409676 1686 6456493 SGTC_2155 5570423 76 µM 0.427089384665965 0.344886877125902 no 1142 0.334657112230385 1584 797402 SGTC_2291 7917025 104.35 µM 0.426754813121985 0.345004381409611 no 1143 0.334778961034274 1523 2964612 SGTC_2670 beta-carotene 100 µM 0.424128449172603 0.345927300522983 no 1144 0.33573606936232 1598 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2072 5231554 129 µM 0.42385860304139 0.346022177966823 no 1145 0.335834468114351 1720 789545 SGTC_2751 anetholtrithion 17.25 µM 0.423287876371247 0.346222876339198 no 1146 0.336042619310407 1691 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2220 6782180 200 µM 0.4225408799226 0.346485625959986 no 1147 0.336315134292581 1620 833803 SGTC_1872 amphotericin b 148 nM 0.422354299945701 0.346551265409579 no 1148 0.336383214767505 1670 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1715 st032160 10.2275 µM 0.421638509493318 0.346803125575384 no 1149 0.3366444466434 1665 5289825 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.421258969648935 0.346936699076431 no 1150 0.336782993907565 1840 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_99 0109-0120 622.8 µM 0.420857643843999 0.347077960520502 no 1151 0.336929518017961 1686 759414 SGTC_774 k060-0086 136 µM 0.420393735776482 0.347241276585244 no 1152 0.337098921760722 1764 5911235 SGTC_1805 st050013 60.3 µM 0.418940016060463 0.347753233553566 no 1153 0.337629985538513 1641 4037144 SGTC_400 oxethazaine 37.5 µM 0.417708456649634 0.348187169616766 no 1154 0.338080144284919 1583 4621 A local anesthetic. SGTC_822 1487-0950 154 µM 0.416504632707864 0.348611525357039 no 1155 0.338520389055725 1659 1958375 SGTC_1745 st081495 74 µM 0.415899865190961 0.348824781373757 no 1156 0.338741639084242 1634 13842402 YBL026W LSM2 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.415191392292963 0.349074667232887 no 1157 0.339000899797542 1679 688761 SGTC_232 clozapine 119 µM 0.414869864455816 0.349188095091258 no 1158 0.339118585834779 1621 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_126 0417-1624 672.48 µM 0.412255664099575 0.350110826049212 no 1159 0.340076020696657 1688 41912 YDL195W SEC31 SGTC_1235 benzylparaben 21.5 µM 0.412043591177858 0.350185720066861 no 1160 0.340153736450839 1605 7180 SGTC_382 3229-0966 23.2 µM 0.410691324283579 0.350663413010519 no 1161 0.340649444654723 1690 5722370 SGTC_3080 9117754 49.47 µM 0.408837296764182 0.351318738468365 no 1162 0.341329533566204 1731 9550191 SGTC_1276 0871-0068 94.2 µM 0.407561239035683 0.35177003153361 no 1163 0.341797913032946 1693 3414906 SGTC_2319 6033012 152.6 µM 0.406389283723484 0.352184691632944 no 1164 0.342228296169515 1534 847246 SGTC_2057 5236571 38.335 µM 0.405760036183671 0.352407403960302 no 1165 0.342459462584557 1723 54684039 YBR257W POP4 SGTC_2883 9059145 45.46 µM 0.404972629302298 0.352686165602801 no 1166 0.342748815073891 1583 16476510 SGTC_132 0417-1715 25.805 µM 0.404805084712206 0.352745490773149 no 1167 0.342810395465258 1770 6769098 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.404721883250168 0.352774952565207 no 1168 0.342840977405538 1594 688803 SGTC_1769 st044406 64.4 µM 0.402642961591974 0.353511388820825 no 1169 0.343605449995882 1621 670903 SGTC_1525 8-methoxypsoralen 92.5 µM 0.400406277269346 0.354304323587007 no 1170 0.344428650763572 1802 4114 Related to psoralen; DNA damaging agent. SGTC_1949 st076024 69.1 µM 0.400241942567593 0.354362607420987 no 1171 0.344489162478521 1562 2921930 SGTC_401 neomycin 50 µM 0.400203515743686 0.354376236578255 no 1172 0.34450331266928 1650 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_152 4469-0003 551.229 µM 0.399769470790256 0.354530195813367 no 1173 0.344663159327709 1654 697280 SGTC_1477 0139-0234 16 µM 0.399266829754935 0.354708516331666 no 1174 0.344848302670252 1661 620880 SGTC_349 k015-0014 24 µM 0.39755124305201 0.355317389711017 no 1175 0.345480503356586 1588 2196908 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.395599064887881 0.356010680440125 no 1176 0.346200413527797 1624 6708784 An antioxidant flavonoid SGTC_1401 3807-4679 7.6 µM 0.394351321072149 0.356454050161059 no 1177 0.34666083898202 1633 3291456 SGTC_2793 7325131 81.82 µM 0.393520908078076 0.356749234345406 no 1178 0.346967392322633 1682 4176441 SGTC_105 0111-0055 734.78 µM 0.392961561321548 0.35694811187831 no 1179 0.347173935961864 1640 5179370 SGTC_2836 9010338 19.48 µM 0.391815331271789 0.35735577907638 no 1180 0.347597333139496 1506 2994051 SGTC_2927 9011802 47.9 µM 0.391709086592727 0.357393574221916 no 1181 0.347636587690213 1559 43912568 SGTC_3138 9097216 49.47 µM 0.389217233505352 0.358280418584878 no 1182 0.348557728057673 1635 25237486 SGTC_1892 st058411 7.36 µM 0.387742413619834 0.358805664074331 no 1183 0.349103332502401 1726 3934738 SGTC_347 4534-1311 26.2 µM 0.386734866329824 0.359164647749316 no 1184 0.349476250585583 1621 2862016 SGTC_1966 st070145 16.1 µM 0.386629065708785 0.359202351162623 no 1185 0.349515418440561 1596 3748532 SGTC_2497 7-hydroxyflavone 100 µM 0.386246162913901 0.359338814961952 no 1186 0.349657184127742 1718 5281894 SGTC_1945 st075991 56.6 µM 0.386187527516143 0.359359713780323 no 1187 0.349678895111847 1608 1084980 SGTC_3110 9122132 49.47 µM 0.386150872916184 0.359372778420252 no 1188 0.349692467494924 1735 918317 SGTC_1224 0823-0416 294 µM 0.382144219673307 0.360801840593974 no 1189 0.351177196872053 1724 3598164 SGTC_189 3970-0742 2.116 µM 0.380710888670223 0.36131354363737 no 1190 0.351708894144893 1761 2891807 SGTC_1335 1486-0900 202 µM 0.379958064080937 0.361582403533297 no 1191 0.351988272378895 1637 X1335 SGTC_175 3793-3120 23.7 µM 0.378029834783462 0.362271352894863 no 1192 0.35270421535795 1638 5322297 SGTC_1749 st037932 54.2 µM 0.376311294572344 0.362885757402351 no 1193 0.353342741768977 1637 594497 SGTC_3164 9100705 49.47 µM 0.375837184884807 0.363055321109141 no 1194 0.353518970761828 1740 17174235 SGTC_3220 9131269 49.47 µM 0.375076752433478 0.363327343224921 no 1195 0.353801692954677 1660 17722206 SGTC_273 hydroxyurea 18.1 mM 0.374085650266227 0.363681984043661 no 1196 0.354170297183389 1691 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_69 0096-0274 206.684 µM 0.373769508224656 0.363795132060691 no 1197 0.35428790343067 1737 6741392 SGTC_597 k018-0003 82.8 µM 0.373755221798589 0.363800245488442 no 1198 0.35429321837307 1752 6786234 SGTC_141 0443-0274 32.331 µM 0.373318154979185 0.363956693084989 no 1199 0.354455832930042 1777 1627241 SGTC_2142 5622915 118.518 µM 0.373115827105588 0.36402912380999 no 1200 0.354531119782867 1651 5322196 SGTC_1417 3966-0327 90.4 µM 0.37238488706659 0.364290831214214 no 1201 0.35480315226089 1679 651118 SGTC_582 0987-0078 156 µM 0.36958085164125 0.365295380420203 no 1202 0.355847410320603 1682 1625765 SGTC_371 0195-0006 7.36 µM 0.369197445964967 0.365432808016214 no 1203 0.355990279720497 1590 3928593 SGTC_2939 9044578 71.43 µM 0.367459487321463 0.36605597683638 no 1204 0.356638152881782 1632 2653634 SGTC_1367 1812-0510 76.9 µM 0.366558074554192 0.366379330028623 no 1205 0.356974343054081 1709 1142582 YDR527W RBA50 SGTC_1163 k060-0048 49.9 µM 0.36634257316844 0.366456648366816 no 1206 0.357054732740141 1679 6809982 SGTC_2683 piperine 63.03 µM 0.361523669904964 0.368187001747999 no 1207 0.358854006887973 1685 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2516 gossypol 71.55 µM 0.361370842800022 0.368241922306532 no 1208 0.358911120738635 1816 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_51 1013-0126 23.419 µM 0.360442058268914 0.368575751892501 no 1209 0.359258289663982 1814 1627850 SGTC_93 0109-0045 59.227 µM 0.359146867866953 0.369041442983156 no 1210 0.359742610886753 1737 88733 SGTC_2537 larixol 68.93 µM 0.358927606542184 0.369120298354544 no 1211 0.359824623403464 1732 6708759 SGTC_3005 9076496 71.4286 µM 0.358854779284196 0.369146491244305 no 1212 0.359851865142771 1739 21368410 SGTC_3161 9100388 49.47 µM 0.358132408776255 0.369406330299639 no 1213 0.360122113342643 1748 25236368 SGTC_885 0865-0106 16.8 µM 0.356991810739671 0.369816728620273 no 1214 0.360548968218249 1623 2793380 SGTC_3323 9138564 53.9225 µM 0.35543094201045 0.370378584734834 no 1215 0.361133385895978 1819 43912313 YNL103W MET4 SGTC_1159 4092-0538 61.2 µM 0.352391881963844 0.371473328840117 no 1216 0.362272194644718 1727 717301 SGTC_594 1487-1584 10.8 µM 0.352119047187728 0.371571661657748 no 1217 0.362374492213202 1636 5013332 SGTC_2346 9031566 143.75 µM 0.350001847431263 0.372335009419901 no 1218 0.363168655593857 1792 4771086 SGTC_2327 6189656 200 µM 0.349774990538467 0.372416831570803 no 1219 0.363253784776835 1816 5349088 SGTC_269 exalamide 29 µM 0.349314079243587 0.372583089585017 no 1220 0.363426764844778 1732 3316 A derivative of salicylamide. SGTC_2724 maprotiline 69.64 µM 0.346682325880397 0.373532858760691 no 1221 0.364414994800845 1767 4011 A tricyclic antidepressant. SGTC_614 0462-0418 107 µM 0.346154577968161 0.373723409555981 no 1222 0.364613274234215 1662 5188303 SGTC_1402 3909-7673 35.9 µM 0.34569668843869 0.373888762015242 no 1223 0.364785336623637 1683 5328014 SGTC_694 1315-0438 43.2 µM 0.345546013262004 0.373943178712243 no 1224 0.364841962200936 1761 6793154 SGTC_3326 9140064 16.379 µM 0.345282958014408 0.374038187759512 no 1225 0.364940828651757 1643 1868434 SGTC_2108 5365811 200 µM 0.344380776167333 0.374364091616835 no 1226 0.365279972053753 1763 780283 SGTC_3094 9117742 49.47 µM 0.343857564886698 0.37455313743002 no 1227 0.365476703152581 1651 17149698 SGTC_1131 3454-3128 32.3 µM 0.343371858341989 0.374728659089566 no 1228 0.365659363891607 1804 710982 SGTC_249 wiskostatin 11.211 µM 0.343267423452534 0.3747664025226 no 1229 0.365698642933375 1802 2775510 A n-wasp and actin depolymerizer. SGTC_191 3914-0123 66.505 µM 0.342008494918986 0.375221481596286 no 1230 0.366172249662037 1675 3144412 SGTC_1459 k035-0031 35.7 µM 0.340591639847935 0.375733855923125 no 1231 0.36670551199267 1618 3877128 YMR208W ERG12 SGTC_964 1287-0107 19.4 µM 0.340064362705174 0.375924590066786 no 1232 0.366904029278823 1818 51516812 YPR165W RHO1 SGTC_1254 0550-0035 264 µM 0.339338533089881 0.376187197000813 no 1233 0.367177358828303 1804 15121435 SGTC_2400 5203494 178.7 µM 0.339220823264245 0.376229790110378 no 1234 0.367221691796679 1660 6777674 SGTC_199 4063-0024 41.6 µM 0.338934457437904 0.376333417414052 no 1235 0.367329552946181 1802 306215 SGTC_544 k015-0020 52.4 µM 0.338695882286311 0.376419757496974 no 1236 0.367419421488958 1717 3008304 SGTC_1682 st012968 530 nM 0.33859345715672 0.376456826935346 no 1237 0.367458006097283 1657 24207270 SGTC_2310 7668677 200 µM 0.338582426464124 0.37646081920309 no 1238 0.36746216155338 1750 2197143 SGTC_3324 9138759 60.749 µM 0.338183068341832 0.376605365220943 no 1239 0.367612617237474 1744 45595710 SGTC_2312 7706453 155.7 µM 0.338088131779523 0.376639729662594 no 1240 0.367648386986175 1697 976098 SGTC_569 4130-2812 160 µM 0.336338855503046 0.377273094567061 no 1241 0.368307676201835 1828 743552 SGTC_1827 berberine 7.24 µM 0.336170557640346 0.377334048044747 no 1242 0.368371126903565 1589 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3123 9126162 49.47 µM 0.333813087792271 0.378188188051941 no 1243 0.369260303378416 1718 25239884 SGTC_1413 3910-0535 34.4 µM 0.331852418551217 0.378899016304364 no 1244 0.370000350340923 1790 2876951 SGTC_908 3448-7491 47.7 µM 0.330772967331969 0.379290539596218 no 1245 0.370407990749384 1676 1203031 SGTC_153 4077-0274 519.67 µM 0.330621729224615 0.379345404445181 no 1246 0.370465115447388 1865 3121976 SGTC_837 0091-0265 12.5 µM 0.330269615814374 0.379473150507501 no 1247 0.370598124554824 1711 759367 SGTC_1471 k673-0312 37 µM 0.330233440666723 0.379486275526537 no 1248 0.370611790415275 1803 24099884 SGTC_2949 9072542 2.23 µM 0.329912504396716 0.379602723277709 no 1249 0.370733037434644 1678 16457352 SGTC_3012 9080433 71.4286 µM 0.328472511941002 0.380125340995953 no 1250 0.371277212327555 1867 17688859 SGTC_1436 4092-1007 8.32 µM 0.327917373131776 0.38032687653601 no 1251 0.371487068768914 1738 2881121 SGTC_1175 0741-0056 27.6 µM 0.327678711511542 0.380413529357915 no 1252 0.371577300614515 1829 765927 SGTC_1829 berberine 14.4 µM 0.326225489025143 0.380941292079138 no 1253 0.372126878951527 1864 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2709 st078560 56 µM 0.325849152578397 0.3810780012866 no 1254 0.372269244045553 1859 17250903 SGTC_2860 9025725 38.96 µM 0.325193535472427 0.381316198345761 no 1255 0.372517300489465 1671 40546248 SGTC_138 0850-0259 40.9225 µM 0.324384217494584 0.381610299602846 no 1256 0.372823583463248 1751 6813004 SGTC_3044 9093193 49.47 µM 0.323417138389866 0.381961819937186 no 1257 0.37318967591565 1680 25236277 SGTC_1365 1672-3266 55.4 µM 0.321226715085722 0.38275836904964 no 1258 0.374019294177175 1849 6415873 SGTC_1017 4239-0030 168 µM 0.321077368453151 0.382812697172665 no 1259 0.374075880207809 1668 1149593 SGTC_380 3970-0968 6 µM 0.320658360544833 0.382965132823196 no 1260 0.374234652834986 1742 2891601 SGTC_137 0438-0332 85.389 µM 0.320293212249961 0.38309798905563 no 1261 0.374373034098581 1758 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1230 0170-0365 3.77 µM 0.318206101695763 0.383857630732094 no 1262 0.375164302326859 1836 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_579 4491-1009 110 µM 0.316896580730204 0.384334482757079 no 1263 0.375661038302879 1933 1271041 SGTC_3204 9114183 49.47 µM 0.316299542183065 0.384551947928872 no 1264 0.375887579307989 1678 17027248 SGTC_1272 0839-0021 27 µM 0.315898709930945 0.384697967358646 no 1265 0.376039695575749 1775 5027250 SGTC_2730 imipramine 71.33 µM 0.315605259037139 0.384804879139637 no 1266 0.37615107271782 1842 3696 A tricyclic antidepressant. SGTC_2998 9066762 71.4286 µM 0.315238096056245 0.384938658484155 no 1267 0.376290441270662 1857 4945196 SGTC_2529 gangaleoidin 93.61 µM 0.314805283720734 0.385096375389381 no 1268 0.376454749868861 1754 4565183 SGTC_2016 5121758 140 µM 0.314424292502644 0.385235224402012 no 1269 0.376599404139382 1736 2795203 SGTC_2391 6285546 200 µM 0.312920317444077 0.38578347886019 no 1270 0.377170600560434 1713 846083 SGTC_61 0978-8327 98.565 µM 0.312117359065511 0.386076280375368 no 1271 0.377475667220587 1805 6150059 YHR072W ERG7 SGTC_1961 st076550 68.7 µM 0.311295753429944 0.386375948858793 no 1272 0.377787897649883 1773 1579337 SGTC_2506 ethyl hematommate 54.16 µM 0.311125283637396 0.386438133687032 no 1273 0.377852690391403 1687 3940691 An allergen. SGTC_943 3253-1379 105 µM 0.310934479514002 0.386507739633946 no 1274 0.377925215950693 1842 668464 SGTC_3047 9092122 49.47 µM 0.310315830382249 0.386733449896238 no 1275 0.378160397023529 1725 17173831 SGTC_1705 st027868 56.3335 µM 0.31025212358908 0.386756695098236 no 1276 0.378184617891961 1853 292948 SGTC_3279 9140807 49.47 µM 0.308186652580689 0.387510559522178 no 1277 0.378970154107466 1760 45595718 SGTC_2215 7188065 200 µM 0.307404664031786 0.387796083932328 no 1278 0.379267689283625 1859 940217 SGTC_2472 5377652 49.4 µM 0.307048185873746 0.387926263548618 no 1279 0.379403347742346 1744 1610903 SGTC_496 calpeptin 138 µM 0.306908726360251 0.387977195163357 no 1280 0.379456423374234 1741 73364 A calpain inhibitor. SGTC_612 0302-0167 22.4 µM 0.305228673899939 0.388590913576714 no 1281 0.38009599756877 1866 235821 SGTC_721 1187-1332 279 µM 0.304484311494476 0.388862916086849 no 1282 0.380379471658754 1745 25730 SGTC_1842 st055362 61.2 µM 0.303719848303047 0.389142320476623 no 1283 0.380670667572617 1830 676032 SGTC_581 0958-0271 211 µM 0.302156616052532 0.389713846089051 no 1284 0.381266337380679 1725 4591145 SGTC_3263 9137018 49.47 µM 0.299003440054241 0.390867387930533 no 1285 0.382468710389724 1679 43844957 SGTC_3267 9137951 49.47 µM 0.298837874365329 0.39092798427948 no 1286 0.38253187553903 1800 16643986 SGTC_2882 9058044 58.44 µM 0.298695190380478 0.390980208145225 no 1287 0.382586313571413 1682 18076804 SGTC_2330 7979373 200 µM 0.297926829146404 0.391261470358797 no 1288 0.382879505281163 1656 1863007 SGTC_683 panaxydol 45 µM 0.297850293678087 0.391289489640916 no 1289 0.382908713406648 1878 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1107 amlodipine 47 µM 0.295205803510953 0.392257970861489 no 1290 0.383918334446634 1766 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_117 lucigenin 22.078 µM 0.293907703913147 0.39273361348704 no 1291 0.38441421555056 1690 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1933 st074711 15.9 µM 0.292881920697631 0.39310958879638 no 1292 0.384806204198984 1819 17250958 SGTC_1303 1160-0052 261 µM 0.292143438441939 0.393380322851105 no 1293 0.385088477763133 1858 3562476 SGTC_2141 5621638 7.665 µM 0.291528490773595 0.39360580739781 no 1294 0.385323578598628 1911 2856238 SGTC_2000 st075254 36.4 µM 0.291180323459283 0.393733486686525 no 1295 0.385456705247115 1779 17234175 SGTC_2518 prenyletin 46.28 µM 0.290809847607488 0.393869359468579 no 1296 0.385598376698891 1898 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2625 euphol 100 µM 0.290247646744028 0.39407557246961 no 1297 0.385813393715626 1932 6708538 A triterpene alcohol. SGTC_1563 conessine 56.1 µM 0.287560519187968 0.395061609246515 no 1298 0.386841584982017 1938 441082 An anti-amoebic, histamine inhibitor. SGTC_1416 3966-0321 25.3 µM 0.287200580710738 0.395193739248041 no 1299 0.386979370849048 1821 582530 YLR208W SEC13 SGTC_3058 9093861 49.47 µM 0.28704577378764 0.395250571108528 no 1300 0.38703863593065 1847 17217477 SGTC_1034 k072-0165 12.7 µM 0.286506198719227 0.395448674330051 no 1301 0.387245223242756 1930 5835461 SGTC_1911 st060208 74.3 µM 0.286234608874032 0.395548397879286 no 1302 0.387349219037799 1891 688783 SGTC_2048 5246248 200 µM 0.285222541183347 0.395920073508238 no 1303 0.387736825965796 1938 677046 SGTC_2652 actinonin 100 µM 0.283330121234746 0.396615306794959 no 1304 0.388461894730717 1851 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_215 1287-0124 461.5 µM 0.282754828126587 0.39682672204847 no 1305 0.388682391842676 1944 5560863 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.282218852797426 0.39702371564995 no 1306 0.388887851598755 1759 6708561 SGTC_1981 st071826 47 µM 0.280704675222581 0.397580381771924 no 1307 0.389468461283591 1808 11838600 SGTC_2355 9061122 103.12 µM 0.27965804532287 0.397965282575457 no 1308 0.389869934687498 1910 5302957 SGTC_2379 9035213 200 µM 0.2792542214425 0.398113816408397 no 1309 0.390024867636853 1962 646551 SGTC_3074 9116018 49.47 µM 0.279025836293942 0.398197827195142 no 1310 0.39011249868261 1817 17027303 SGTC_1764 st044502 93.5 µM 0.278393891678978 0.398430310696584 no 1311 0.390355003994069 1809 8407 SGTC_1388 3346-4487 254 µM 0.277704218693005 0.398684072793197 no 1312 0.390619710943226 1869 3345614 SGTC_1743 st037606 46.3785 µM 0.276246421944558 0.399220603454308 no 1313 0.391179402152425 1810 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_22 0964-0034 14.468 µM 0.276162859340833 0.399251363795474 no 1314 0.391211491145 1805 138402 SGTC_3320 9137005 35.139 µM 0.275809990404769 0.399381265744736 no 1315 0.391347005003345 1796 4908713 SGTC_3197 9113331 49.47 µM 0.275727559676352 0.399411612646468 no 1316 0.391378663150926 1935 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2106 5357045 167.29 µM 0.275554907126908 0.399475176712912 no 1317 0.391444974006049 1880 668842 SGTC_1391 3442-0225 151 µM 0.275365068219974 0.39954507121476 no 1318 0.391517889285906 1819 5227075 SGTC_1431 4049-0260 9.09 µM 0.274457924258697 0.399879106042086 no 1319 0.391866367052142 1885 3854841 SGTC_550 4123-0385 25.7 µM 0.273711306154909 0.400154085914699 no 1320 0.392153244201087 1810 5731123 SGTC_2121 5257820 149.641 µM 0.271600821933835 0.400931645803883 no 1321 0.392964483696406 1959 791256 SGTC_3282 9108498 15.4605 µM 0.271131356288279 0.401104663229655 no 1322 0.393145002835281 1803 16459645 SGTC_344 k064-0035 6.43 µM 0.270500324121414 0.401337255125609 no 1323 0.393387683800551 1749 5088750 SGTC_2079 5212404 121 µM 0.269401027643262 0.401742527845434 no 1324 0.393810547720596 1958 758462 SGTC_3199 9111318 49.47 µM 0.266548034082849 0.402794820315142 no 1325 0.394908585546709 1900 8548020 SGTC_1490 4089-0339 670 nM 0.264129952154923 0.403687252821129 no 1326 0.395839892348272 1947 742542 SGTC_1145 3546-0597 10.2 µM 0.263159590020142 0.404045522080122 no 1327 0.396213787899747 1847 875334 SGTC_839 0122-0028 230 µM 0.262842147040055 0.404162743299843 no 1328 0.396336124338797 1875 759448 SGTC_2296 7971656 126.45 µM 0.262743442824734 0.40419919326455 no 1329 0.396374165132173 1808 666570 SGTC_2178 5812956 200 µM 0.26273743046261 0.404201413565267 no 1330 0.396376482339916 1866 5403383 SGTC_3003 9075612 71.4286 µM 0.261509813998846 0.404654823674064 no 1331 0.396849691147928 1856 6501993 SGTC_1720 st037298 9.481 µM 0.260912277855959 0.404875565139411 no 1332 0.397080078174703 1806 597396 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.260741930380933 0.404938500356085 no 1333 0.397145764213149 1824 689007 SGTC_295 k015-0027 31 µM 0.260016655348121 0.405206482174733 no 1334 0.39742546312137 1878 3887424 SGTC_623 k072-0108 16.9 µM 0.259396917968775 0.405435504117907 no 1335 0.397664503730686 1859 5382803 SGTC_929 2805-0021 398 µM 0.258424670537648 0.405794860227913 no 1336 0.398039589366173 1846 3098024 SGTC_2226 7298446 200 µM 0.257622028446338 0.406091587702919 no 1337 0.398349313595098 1949 3283010 SGTC_1624 st003710 6.25 µM 0.256882169130728 0.406365152904585 no 1338 0.39863486788789 1950 24207033 SGTC_2117 5521686 200 µM 0.255680068418963 0.406809730668511 no 1339 0.399098943410409 1800 803312 SGTC_3346 9158254 43.5805 µM 0.254301866740701 0.407319584344433 no 1340 0.399631178874271 1854 17639500 SGTC_2512 diallyl trisulfide 49.23 µM 0.25412614654379 0.407384601804049 no 1341 0.399699052126271 1941 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_994 3910-0338 138 µM 0.251493742131044 0.408358910687248 no 1342 0.400716199906489 1937 3479481 SGTC_3349 9149703 23.001 µM 0.251095911003393 0.408506205900694 no 1343 0.400869978602278 1888 4910494 SGTC_1958 st076513 41.9 µM 0.25008835418563 0.408879307129903 no 1344 0.401259510947863 1847 732122 YGL099W LSG1 SGTC_2026 5148700 152 µM 0.248802093631554 0.409355733134145 no 1345 0.401756935770401 1844 79838 SGTC_1694 st024011 44.9 µM 0.248489751972042 0.409471443527101 no 1346 0.401877749111229 1900 2787533 SGTC_2762 leflunomide 42.06 µM 0.248267738778442 0.409553695545174 no 1347 0.401963629223046 1853 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_427 1354-0053 47.3 µM 0.247615630526383 0.409795313292588 no 1348 0.402215907938386 1952 6813657 SGTC_1493 4348-0038 111 µM 0.247586148679295 0.409806237653285 no 1349 0.402227314435183 1901 800424 SGTC_1377 2944-0135 198 µM 0.247304236153706 0.409910702557087 no 1350 0.402336390309195 1861 1894137 SGTC_1334 1486-0610 236 µM 0.246640704131928 0.410156604792926 no 1351 0.402593150069675 1909 3742339 SGTC_2181 6316240 54.2555 µM 0.246386889506873 0.410250676795973 no 1352 0.402691377068649 1809 12779990 SGTC_2659 sanguinarine 24.21 µM 0.245548719073019 0.410561366838128 no 1353 0.403015795072755 1876 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2837 9008476 45.46 µM 0.245133210101115 0.410715407052415 no 1354 0.403176644641515 1897 2992805 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.244967721989731 0.410776761727807 no 1355 0.403240712060976 1865 688788 SGTC_1129 3453-1384 223 µM 0.244879960578282 0.410809300134849 no 1356 0.403274689254518 1891 1084452 SGTC_333 3486-0131 40.1 µM 0.243924076453248 0.411163743284891 no 1357 0.403644810985896 1989 6744690 SGTC_2558 carylophyllene oxide 100 µM 0.240619207498558 0.412389750386362 no 1358 0.404925131036305 1935 6708694 An oxygenated terpenoid and antifungal agent. SGTC_329 k048-0121 21.3 µM 0.239743074640785 0.412714913287865 no 1359 0.405264719909669 1879 6832902 SGTC_990 3985-0011 41.3 µM 0.239666633206314 0.412743286166005 no 1360 0.405294351977371 1897 5399565 YGL099W LSG1 SGTC_2195 6536160 144.242 µM 0.239386198078247 0.412847379582369 no 1361 0.405403065635668 1847 3834386 SGTC_1529 apigenin 74 µM 0.237826476837287 0.413426436922578 no 1362 0.40600784110958 1996 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2880 9042983 58.44 µM 0.237818741639713 0.413429309138784 no 1363 0.406010840960808 1874 6464714 SGTC_3077 9117319 49.47 µM 0.23717312729337 0.413669053524175 no 1364 0.406261241459146 1951 17154678 SGTC_2959 9079155 11 µM 0.234559503541493 0.414639932467998 no 1365 0.407275322077911 1905 16189457 SGTC_866 0495-0101 262 µM 0.234358111204979 0.414714765104287 no 1366 0.407353487777528 1790 635694 SGTC_1774 st048371 48.465 µM 0.233363786397786 0.415084278035748 no 1367 0.40773946558617 1821 4242727 SGTC_902 1120-0002 2.07 µM 0.232996765924133 0.415220689903928 no 1368 0.407881958543168 1858 3280475 SGTC_2140 5586273 200 µM 0.232650677147671 0.415349331373225 no 1369 0.40801633608853 1942 854421 SGTC_1130 3454-2858 15.9 µM 0.23217161753575 0.415527413177626 no 1370 0.408202360707961 1808 715628 YIL048W NEO1 SGTC_1369 1866-0067 208 µM 0.230827481607799 0.416027164090532 no 1371 0.408724415228373 1993 3531355 SGTC_2728 chlorpromazine 9.18 µM 0.22888214218559 0.416750683306417 no 1372 0.409480260320909 1947 2726 A thorazine and dopamine antagonist. SGTC_2093 5331342 194.4 µM 0.22871399425196 0.416813234907372 no 1373 0.409545608615091 2012 33839 SGTC_1669 st015249 58.4 µM 0.228448395036267 0.416912043005619 no 1374 0.409648835078377 2049 722793 SGTC_796 1234-0020 70.7 µM 0.228036602170271 0.417065248373895 no 1375 0.409808892816195 1882 46495034 SGTC_1569 carminic acid 40.6 µM 0.227831397630729 0.417141598345985 no 1376 0.409888658369352 2017 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_106 0092-0003 11.579 µM 0.227379587206076 0.417309713401776 no 1377 0.410064295833184 2013 1072148 SGTC_180 1486-1293 102.781 µM 0.226355508326987 0.417690820907314 no 1378 0.410462464545687 2064 4140536 SGTC_1831 st055328 12 µM 0.226217162843291 0.417742311649182 no 1379 0.41051626128054 2005 1103068 SGTC_3232 9132874 49.47 µM 0.225841394452653 0.417882175828419 no 1380 0.410662390283728 1864 3784940 SGTC_1768 st044301 37.178 µM 0.225292369183454 0.418086546356431 no 1381 0.410875917801649 1878 3931349 SGTC_128 0906-2981 13.371 µM 0.22455668667127 0.418360433309387 no 1382 0.411162081660585 2019 6740226 SGTC_480 am 92016 50 µM 0.224096697679972 0.418531702553267 no 1383 0.41134103100671 1870 2129 K+ channel blocker. SGTC_1511 0906-3109 28.5 µM 0.223895004001789 0.418606804709804 no 1384 0.411419501643123 1960 2882180 SGTC_1081 sertraline 6 µM 0.22353429898838 0.418741123327539 no 1385 0.411559845821963 2017 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1671 st016596 74.5 µM 0.222875067362816 0.418986631161921 no 1386 0.411816370850608 1914 2829167 SGTC_251 melphalan 456.522 µM 0.222553780940849 0.419106294529379 no 1387 0.411941405839703 1964 460612 A DNA alkylator. SGTC_3097 9117246 49.47 µM 0.222032120321308 0.419300603351075 no 1388 0.412144439463618 1911 16423892 SGTC_1403 3909-7815 62.9 µM 0.222018234901256 0.419305775679409 no 1389 0.412149844078787 1914 6615483 SGTC_868 0527-0199 213 µM 0.221041494631779 0.419669647027708 no 1390 0.412530061960086 1917 2849450 SGTC_1343 1487-0095 224 µM 0.220758218794014 0.419775190465547 no 1391 0.412640348755617 2032 4560101 YGL055W OLE1 SGTC_2902 5787006 60.46 µM 0.219639038728686 0.420192233020746 no 1392 0.41307614260575 1878 591003 SGTC_1484 3473-2379 286 µM 0.21889244947249 0.42047048609666 no 1393 0.413366914149986 2036 671917 SGTC_744 1594-0068 283 µM 0.218717615447749 0.420535652313158 no 1394 0.413435013028057 1892 668392 SGTC_1204 4049-0315 18.3 µM 0.21735946701373 0.421041951585923 no 1395 0.41396410834369 2017 588402 SGTC_3247 9135149 49.47 µM 0.215119823290203 0.42187714521811 no 1396 0.414836949472028 1946 8934436 YOR116C RPO31 SGTC_2624 nerol 100 µM 0.213182980300599 0.422599703915221 no 1397 0.415592121449311 1980 637566 A natural product oil. SGTC_2753 fluvastatin 17.09 µM 0.210959103941259 0.423429664448326 no 1398 0.416459591742043 1951 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.210341358814383 0.423660270144824 no 1399 0.416700628790073 1969 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_107 0358-0022 2.6945 µM 0.210295924263629 0.423677232001838 no 1400 0.416718358067175 2030 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2842 9000675 19.48 µM 0.210143014127489 0.423734318228393 no 1401 0.416778027254181 1806 2989072 SGTC_2005 4024620 188 µM 0.20924683244059 0.424068923553127 no 1402 0.417127777257261 1967 236743 SGTC_2778 tioconazole 65.09 nM 0.207739742958785 0.424631745458724 no 1403 0.417716092084489 1952 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1070 indatraline 8.81 µM 0.206989782525476 0.42491187519666 no 1404 0.418008919034871 1904 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1035 k081-0041 55.2 µM 0.206813913700998 0.424977572273583 no 1405 0.418077594752384 2059 731709 SGTC_3233 9132340 49.47 µM 0.206775638098021 0.424991870679269 no 1406 0.418092541476039 1904 17682950 SGTC_1902 st060212 70.5 µM 0.20659103712998 0.425060832429008 no 1407 0.418164630300408 2054 688944 SGTC_2700 st077718 96.8 µM 0.206204724415125 0.425205155454634 no 1408 0.418315498801218 1888 904970 SGTC_1701 st028638 40.4 µM 0.205644916637301 0.425414312489527 no 1409 0.418534144457012 2019 3490878 SGTC_262 fenpropimorph 62.5 µM 0.205274797671817 0.425552608961451 no 1410 0.418678716661411 1936 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1078 idebenone 36.1 µM 0.204895878289644 0.425694203233946 no 1411 0.41882673777658 1971 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_78 0336-0123 156.75 µM 0.204662809165959 0.425781301066765 no 1412 0.418917789638243 1851 6765896 SGTC_662 k832-1615 104 µM 0.204528853212017 0.425831361989055 no 1413 0.418970123456516 1973 5878478 SGTC_2881 9058953 51.95 µM 0.204293440701487 0.425919341320898 no 1414 0.419062097724797 1999 17122249 SGTC_828 2074-0507 139 µM 0.202346982468051 0.426646920602275 no 1415 0.419822736421536 2039 X828 SGTC_2405 ticlatone 3.52 µM 0.202339174572198 0.426649839670866 no 1416 0.419825788203335 1815 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_817 1391-0715 46 µM 0.20214027310458 0.426724202548174 no 1417 0.419903532141071 1895 1353946 SGTC_1735 st034310 56.75 µM 0.200804987182433 0.42722349042207 no 1418 0.420425531576833 1992 871153 SGTC_1710 st031758 61.5 µM 0.20069695481903 0.427263890811382 no 1419 0.420467770486807 2053 5394341 SGTC_2210 7115885 190.385 µM 0.200471651384749 0.427348149002872 no 1420 0.420555863438293 1968 2927039 SGTC_2300 7976697 71.57 µM 0.19905947907216 0.427876343608595 no 1421 0.421108108937038 1904 2236109 SGTC_2741 miltefosine 3.04 µM 0.1981041789448 0.428233727738601 no 1422 0.421481777653293 1981 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2727 riluzole 51.77 µM 0.19646760236683 0.428846118580735 no 1423 0.422122094024875 2087 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1605 st000082 49.1 µM 0.195609238781216 0.429167378374649 no 1424 0.422458014239498 2019 1114022 SGTC_3067 9117431 49.47 µM 0.195132181507875 0.429345946931431 no 1425 0.422644734796956 1927 17150885 SGTC_1619 st003326 88.7 µM 0.193622213329498 0.429911242212003 no 1426 0.423235851806565 2053 2849032 SGTC_2414 st077232 92.9 µM 0.193564885561562 0.429932707169942 no 1427 0.423258297692616 1822 729801 SGTC_2972 9093619 59.92 µM 0.193262011574783 0.430046114242882 no 1428 0.423376887900135 1865 25236256 SGTC_1637 st007924 17.4 µM 0.193124488183442 0.430097609924816 no 1429 0.42343073742992 1958 683336 SGTC_1284 0929-0043 16 µM 0.191604897746336 0.430666700061799 no 1430 0.424025852876655 1955 1239883 SGTC_939 1165-0479 45.3 µM 0.190722932902709 0.430997064063763 no 1431 0.42437133531412 2098 1377347 SGTC_3200 9114385 49.47 µM 0.188745307777355 0.431738012717066 no 1432 0.425146219641831 1920 17018030 YLR208W SEC13 SGTC_2233 sulbentine 40.3845 µM 0.18841660720083 0.431861188958728 no 1433 0.425275041088127 2027 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3229 9132204 49.47 µM 0.187736833336333 0.432115946326996 no 1434 0.425541477393956 1998 17682924 SGTC_1028 k015-0029 4.8 µM 0.187225502952319 0.432307595109042 no 1435 0.425741914956085 1990 4588309 SGTC_3344 9148862 3.898 µM 0.186724642610879 0.43249533511814 no 1436 0.425938266946964 2048 4905352 SGTC_203 k066-0004 30.888 µM 0.185714742131636 0.432873927516753 no 1437 0.426334233445665 2109 6795412 SGTC_960 1222-0186 7.7 µM 0.184948266790857 0.433161305633315 no 1438 0.426634806275408 2011 3126296 SGTC_1067 clotrimazole 1.36 µM 0.183406563426711 0.43373945045402 no 1439 0.42723951317416 1966 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_181 1447-1644 8.07 µM 0.182319303811689 0.434147262417081 no 1440 0.427666075158019 2085 534600 SGTC_1607 st000305 50.6 µM 0.182093142752381 0.434232100274778 no 1441 0.427754815030424 2076 5457690 SGTC_2806 7952793 58.44 µM 0.18170520357494 0.434377631622181 no 1442 0.427907041048021 2007 2972490 SGTC_2945 9067681 61.76 µM 0.181263417140806 0.434543374037624 no 1443 0.428080409613754 2071 16456930 SGTC_658 3253-0951 102 µM 0.180349893036581 0.434886131956984 no 1444 0.428438944394243 2003 1184878 SGTC_2975 9084847 53.72 µM 0.177533379684129 0.435943206044754 no 1445 0.429544724221817 1943 27211724 SGTC_2398 5228213 48.84 µM 0.177238531676335 0.436053892935164 no 1446 0.429660515421961 2118 80771 YMR134W ERG29 SGTC_759 3486-0358 89.3 µM 0.176338415084418 0.43639183054635 no 1447 0.430014041994884 2129 875103 SGTC_3185 9108267 49.47 µM 0.174671454915274 0.437017792512279 no 1448 0.430668899296784 1953 4910486 SGTC_1244 0416-0015 52.5 µM 0.174656145916164 0.437023541943859 no 1449 0.430674914250038 1981 96201 SGTC_168 3970-0862 530.542 µM 0.174526030478472 0.437072408497396 no 1450 0.430726037658357 2011 3135186 SGTC_2635 hydroquinidine 100 µM 0.173661122184825 0.437397260480616 no 1451 0.431065896592629 1991 442912 An experimental heart treatment. SGTC_1409 3909-8004 61.9 µM 0.173039890713994 0.437630615640247 no 1452 0.431310036146404 2015 2119279 SGTC_1518 st038567 90.8 µM 0.172620914485608 0.437788009272542 no 1453 0.431474705652162 2101 77966 SGTC_1458 k015-0034 6.33 µM 0.172221566798745 0.437938038361988 no 1454 0.431631671672559 1921 3598957 SGTC_1565 sinapyl alcohol 95.1 µM 0.171307261223039 0.438281563165418 no 1455 0.431991085615812 1951 5280507 A phenol propionate derived from cinnamic acid. SGTC_1742 st038235 28.8875 µM 0.170568352344042 0.438559221549814 no 1456 0.432281592184601 1990 564103 YBR002C RER2 SGTC_341 1486-1430 230 µM 0.170336003845757 0.438646536959651 no 1457 0.432372948999714 1985 2054753 YPL210C SRP72 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.167812854834921 0.439594915207649 no 1458 0.433365254610927 2007 5379071 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.16605869437357 0.440254457726523 no 1459 0.434055379940099 2033 5106787 A p450 inhibitor. SGTC_723 4182-0001 115 µM 0.165955175558894 0.440293384712497 no 1460 0.434096112822825 1961 744821 YLR208W SEC13 SGTC_2362 9071156 126 µM 0.165490313646529 0.440468197466296 no 1461 0.434279036653949 2086 653133 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.164501298585506 0.440840158189477 no 1462 0.434668262275385 2079 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2919 7978188 46.38 µM 0.163675120934463 0.441150917083436 no 1463 0.434993452004253 2116 2980291 SGTC_2895 9054447 58.44 µM 0.162460576024679 0.441607822381016 no 1464 0.435471585785837 1997 2697450 SGTC_3212 9128307 49.47 µM 0.162424177865005 0.44162151637636 no 1465 0.435485916225444 1800 27243542 SGTC_2023 5144124 124 µM 0.16149663023563 0.441970508976172 no 1466 0.435851132602298 2011 2830192 SGTC_2242 6630449 61.2675 µM 0.161146135016069 0.442102395604215 no 1467 0.435989152275583 2031 691249 YDR170C SEC7 SGTC_3004 9076122 71.4286 µM 0.160863474467381 0.442208761635412 no 1468 0.436100465369106 2093 44782551 SGTC_2517 totarol 10 µM 0.160485419245858 0.442351031486322 no 1469 0.436249353257477 1955 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1919 st067113 52.3 µM 0.159292527150509 0.442799989646151 no 1470 0.43671920402905 2032 1268243 SGTC_1168 k815-0004 80.5 µM 0.159175968916551 0.442843861577959 no 1471 0.43676511824128 2020 642433 SGTC_1439 4092-1168 46 µM 0.155386919562666 0.44427041931005 no 1472 0.438258147797005 2098 2886240 SGTC_484 loperamide 105 µM 0.154611070565898 0.444562612190007 no 1473 0.438563970951235 2116 3955 An opioid-receptor agonist. SGTC_2534 helenine 20.12 µM 0.154183311796779 0.444723723529909 no 1474 0.438732600050835 2031 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2138 5575593 77.673 µM 0.153887492877469 0.444835146302487 no 1475 0.43884922293522 2011 762213 SGTC_1304 1165-0502 251 µM 0.151683000878807 0.445665624103399 no 1476 0.439718482677442 2064 767425 SGTC_83 0170-0301 39.027 µM 0.150832936790884 0.445985924758465 no 1477 0.440053751845186 2147 3089716 SGTC_648 0375-0473 33.3 µM 0.150363589212733 0.446162788115712 no 1478 0.440238883114659 2039 1713139 SGTC_1352 1496-0991 99 µM 0.15016227899062 0.446238650749317 no 1479 0.440318292701522 2048 3000039 SGTC_1478 0453-0656 35.7 µM 0.147802795013838 0.447127955087656 no 1480 0.441249201733061 2116 5258496 SGTC_755 1995-0008 37.3 µM 0.147684444574132 0.447172569152702 no 1481 0.441295904220566 2143 689533 SGTC_182 3448-4371 550.524 µM 0.146726272616419 0.447533791751805 no 1482 0.441674040243153 2206 3491403 SGTC_186 3455-3465 67.277 µM 0.146510540328782 0.447615126984487 no 1483 0.44175918486262 2101 755278 SGTC_1342 1486-1464 234 µM 0.14526796159148 0.448083645909579 no 1484 0.442249654655655 2069 3253938 SGTC_3006 9075424 71.4286 µM 0.145106890459333 0.448144383694695 no 1485 0.442313239036335 2015 7465181 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.144106197106374 0.448521759053298 no 1486 0.442708305609901 2029 2724 A muscle relaxant with antifungal properties. SGTC_833 3852-0053 558 µM 0.143872285697832 0.448609977023241 no 1487 0.44280066038958 2086 3123681 SGTC_983 1491-0821 12.2 µM 0.142521820385236 0.449119344649057 no 1488 0.44333392256118 2150 46495113 SGTC_3090 9117696 49.47 µM 0.142116765889791 0.44927213922745 no 1489 0.443493887664021 2142 7923821 SGTC_2032 5185112 25.99 µM 0.14160745690455 0.449464271337676 no 1490 0.443695038268388 2132 5718189 SGTC_583 1488-1091 88.9 µM 0.14158928054951 0.449471128418963 no 1491 0.443702217253283 2192 4303273 SGTC_849 0386-0493 241 µM 0.141090690939084 0.449659228634895 no 1492 0.443899148820576 2054 726119 SGTC_811 0416-0114 265 µM 0.140862564696637 0.449745296367675 no 1493 0.443989258125316 2025 6612453 SGTC_1253 0550-0034 176 µM 0.139346962343558 0.450317164413751 no 1494 0.444587990632236 2053 5969915 SGTC_743 1275-0778 158 µM 0.138594182946843 0.450601242037761 no 1495 0.444885420141315 2149 2849257 YMR203W TOM40 SGTC_526 4469-0568 170 µM 0.137380885319207 0.451059159406121 no 1496 0.445364869545357 1991 2901964 SGTC_1787 fluconazole 80 µM 0.137000951976054 0.451202565572245 no 1497 0.445515021319684 2087 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2358 9037157 4 µM 0.13690465575957 0.451238913674184 no 1498 0.445553079363393 2086 2388925 SGTC_1232 0279-0259 161 µM 0.136053961826871 0.451560035498263 no 1499 0.445889311076346 2025 1560000 SGTC_2575 plumbagin 510 nM 0.13548817892249 0.451773626043579 no 1500 0.446112954965308 2010 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1514 1189-1591 158 µM 0.135025298916683 0.451948379766485 no 1501 0.446295935928122 2149 767698 YMR146C TIF34 SGTC_24 0417-1663 219 µM 0.132318128631417 0.452970618551146 no 1502 0.447366334437211 2054 4329390 SGTC_433 pimozide 108 µM 0.132217290369269 0.453008701563596 no 1503 0.447406212723054 1983 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_43 0570-0105 72.5 µM 0.131955592833581 0.45310753739771 no 1504 0.447509708151581 2108 1114046 YDL195W SEC31 SGTC_534 k292-0788 63.4 µM 0.131486887825803 0.453284561416376 no 1505 0.447695079259495 2217 4146317 SGTC_577 r071-0003 38.6 µM 0.131290206800258 0.453358848146728 no 1506 0.447772869287392 2139 4568517 YMR134W ERG29 SGTC_438 sphingosine 6.67 µM 0.130512097825954 0.4536527570972 no 1507 0.448080641663251 1935 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1319 1306-0155 43.7 µM 0.129974146776393 0.453855967945474 no 1508 0.448293440520965 2114 3122360 SGTC_713 1488-1073 324 µM 0.129967220183759 0.453858584542664 no 1509 0.448296180590468 2191 3312542 SGTC_2832 7992762 51.95 µM 0.129521496238464 0.454026965912596 no 1510 0.448472508337628 1897 2985177 SGTC_549 1661-1316 519 µM 0.128794963006956 0.454301446453301 no 1511 0.448759945636312 2194 2857282 SGTC_2800 7887935 81.82 µM 0.12846903697469 0.454424586741366 no 1512 0.448888900032954 2081 2961002 SGTC_1333 1482-0047 286 µM 0.127925662122073 0.454629892551932 no 1513 0.449103901229309 2209 3811116 SGTC_2088 5278280 127.392 µM 0.127323433484934 0.454857449516652 no 1514 0.449342207002039 2091 791502 SGTC_1498 4478-3555 97.6 µM 0.127161947255923 0.454918470917253 no 1515 0.449406111259388 2196 3437919 SGTC_1943 st076331 65.2 µM 0.127065803673541 0.454954801554807 no 1516 0.449444158372924 2210 24208415 SGTC_1361 1608-0041 5.61 µM 0.125543507059784 0.455530095439832 no 1517 0.450046641911082 2099 X1361 SGTC_386 1509-0011 3.07 µM 0.125098181628442 0.455698406869636 no 1518 0.450222911419729 2123 3107280 SGTC_16 erodoxin 22.806 µM 0.124459593624251 0.455939776053623 no 1519 0.450475695594428 2154 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1534 6-azauridine 81.6 µM 0.124321984763346 0.455991790654836 no 1520 0.450530170505662 2168 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_285 1486-1325 46 µM 0.124224273987919 0.456028724686591 no 1521 0.450568851617124 2172 22310230 SGTC_2344 7990960 76.95 µM 0.123953380836372 0.456131122505725 no 1522 0.450676093504594 2087 140813 SGTC_2816 7982706 58.44 µM 0.123895807074771 0.456152885807448 no 1523 0.450698886419782 2069 2981853 SGTC_1854 st056233 32.9 µM 0.123868346837086 0.456163266023876 no 1524 0.450709757729013 2205 5393174 SGTC_1606 st000094 49.2 µM 0.123855085159989 0.456168279067617 no 1525 0.450715007944176 2203 1242210 SGTC_1775 st081588 35.1725 µM 0.120767851380383 0.457335471857105 no 1526 0.451937457283134 2184 1426443 YGL099W LSG1 SGTC_856 0433-0016 11.3 µM 0.120670800472249 0.457372169987103 no 1527 0.451975893899464 2100 3911780 SGTC_2119 5528445 120.635 µM 0.120425659026904 0.457464867621995 no 1528 0.452072983172748 2154 791935 SGTC_1594 piperine 70.1 µM 0.119088366179001 0.457970591327909 no 1529 0.452602673797389 2093 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2266 7929956 200 µM 0.119087378485832 0.457970964868839 no 1530 0.452603065045767 2205 2967153 SGTC_1993 st073995 70.8 µM 0.118276240292608 0.458277746038382 no 1531 0.452924391369623 2114 3098394 SGTC_1623 st003709 20.3 µM 0.117928492302263 0.458409275682912 no 1532 0.453062158586844 2048 16192618 SGTC_1819 st053448 58.6 µM 0.117891929397934 0.458423105232003 no 1533 0.453076644030239 2119 2857616 SGTC_1640 st009078 66.4 µM 0.117824389198172 0.458448651762397 no 1534 0.453103402182019 2189 690618 SGTC_1281 0884-0031 11.8 µM 0.11759165139589 0.458536684254312 no 1535 0.453195610134872 2126 1548255 SGTC_1085 doxorubicin 7.67 µM 0.116287684331277 0.459029944031082 no 1536 0.453712272935688 2206 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_883 0850-0245 24.6 µM 0.11435269102603 0.459762022088554 no 1537 0.454479107499582 2146 6823229 YPR165W RHO1 SGTC_331 k048-0133 24.5 µM 0.114248584440291 0.459801413271048 no 1538 0.454520369598862 2164 6813582 SGTC_3008 9078912 71.4286 µM 0.113226985595253 0.460187980167219 no 1539 0.454925300912261 2115 16648731 SGTC_2630 antimycin a 100 µM 0.112625557536702 0.460415574572062 no 1540 0.455163710989684 2181 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_143 4032-1194 15.74 µM 0.111705028786239 0.460763949212136 no 1541 0.455528645947212 2086 1806963 SGTC_780 0109-0199 192 µM 0.111536519753752 0.460827724822269 no 1542 0.455595453839436 2226 610414 SGTC_2437 5741531 144.16 µM 0.111050057363672 0.46101184188038 no 1543 0.45578832606974 2205 2262990 SGTC_1587 estradiol valerate 56.1 µM 0.110310507469175 0.461291763897491 no 1544 0.456081562183142 2216 13791 A steroid. SGTC_3116 9124943 49.47 µM 0.110292230537893 0.461298682018263 no 1545 0.456088809403162 2022 41905195 YPL160W CDC60 SGTC_155 k072-0202 43.6 µM 0.109675027688944 0.461532310366705 no 1546 0.456333552967979 2212 5857737 SGTC_984 1492-0255 2.91 µM 0.109477235665147 0.461607182930786 no 1547 0.45641198826904 2139 1585198 SGTC_2036 5160441 105 µM 0.109227617903787 0.461701675648802 no 1548 0.456510977719245 2129 134534 YIL048W NEO1 SGTC_909 3448-9333 149 µM 0.108893770582103 0.461828056816359 no 1549 0.456643373809392 2132 3344074 SGTC_1683 st010134 710 nM 0.10785916719699 0.462219740467948 no 1550 0.457053703977084 2172 3818134 SGTC_423 5-fluorouracil 457 µM 0.106651310626766 0.462677061227913 no 1551 0.45753280534629 2054 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_884 0851-0618 334 µM 0.105350592102425 0.463169596699687 no 1552 0.45804880980071 2214 9642473 SGTC_1771 st048882 4.1505 µM 0.105128999857389 0.463253511388254 no 1553 0.458136724121814 2066 4580403 SGTC_281 1672-3440 14.9 µM 0.104403326506184 0.463528327797199 no 1554 0.458424641470358 2183 6833000 SGTC_1555 citronellol 128 µM 0.103503078089549 0.463869280899075 no 1555 0.458781853327443 2232 8842 A terpine precursor. SGTC_711 k292-0785 179 µM 0.102243450306811 0.464346387041387 no 1556 0.45928172004246 2197 4146315 SGTC_3356 9151811 4.48 µM 0.102185967394791 0.464368160932197 no 1557 0.459304532921911 2152 1859254 YPR165W RHO1 SGTC_932 2857-0803 154 µM 0.100788961611923 0.464897363914931 no 1558 0.459858994787783 2211 674898 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.0977464091313168 0.466050133860658 no 1559 0.461066831409093 2188 364106 SGTC_732 3970-1727 52.7 µM 0.0970512369524629 0.466313562779742 no 1560 0.461342852626031 2228 1275699 SGTC_3225 9130819 49.47 µM 0.0964485837269839 0.466541944464328 no 1561 0.461582153854479 2224 4547121 SGTC_2395 5646831 180.19 µM 0.0959179993149749 0.466743024047326 no 1562 0.461792849553042 2193 6808628 SGTC_1953 st076800 12.1 µM 0.0951754721369112 0.467024439422025 no 1563 0.462087725965617 2011 297591 SGTC_2580 diallyl disulphide 81.36 µM 0.0947579352059265 0.467182691804765 no 1564 0.462253549656369 2159 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1783 st039459 87.517 µM 0.094352243065538 0.467336459814001 no 1565 0.46241467550443 2230 729761 SGTC_2539 epi(13)torulosol 80 µM 0.0938827459955459 0.467514417655803 no 1566 0.462601149997665 2140 6708597 SGTC_3135 9127742 49.47 µM 0.0906999066279028 0.468721008281637 no 1567 0.463865522413548 2109 3643468 SGTC_2044 5102272 200 µM 0.0891387080322052 0.469312952739002 no 1568 0.464485837629055 2158 592666 SGTC_618 k072-0232 33.2 µM 0.0884467917905885 0.469575321649555 no 1569 0.464760786259257 2198 5872756 YGL099W LSG1 SGTC_1072 oxiconazole 14.9 nM 0.0878468897848647 0.469802810220322 no 1570 0.464999184567109 2264 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_725 1497-0963 19 µM 0.0862781881288663 0.47039772327234 no 1571 0.465622638581057 2252 3549977 SGTC_1308 1187-1617 41.4 µM 0.0854429445495909 0.47071450736301 no 1572 0.465954626577687 2228 2882570 SGTC_1080 nisoldipine 24.4 µM 0.0847784169022344 0.470966557012914 no 1573 0.466218776285662 2252 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_367 0335-0881 7.1 µM 0.0835041964576097 0.471449890369694 no 1574 0.466725320378817 2211 23828853 SGTC_1807 st050092 58.9 µM 0.0827751300880633 0.471726456529384 no 1575 0.467015172281682 2192 5008496 SGTC_2908 7930301 100 µM 0.082034726705252 0.472007337258071 no 1576 0.467309549296041 2260 2223178 SGTC_1188 1403-0014 4.57 µM 0.0809247597285944 0.472428442318584 no 1577 0.467750894561777 2179 9614867 SGTC_2885 9057732 51.95 µM 0.0805009493984397 0.472589237848083 no 1578 0.467919420588229 2193 6471414 SGTC_1523 st012844 44.7 µM 0.079909834977038 0.472813516750655 no 1579 0.46815448383308 2144 4274103 SGTC_661 1304-0007 33.6 µM 0.0794149849944929 0.473001277912824 no 1580 0.468351274991709 2194 3117130 SGTC_2416 tofa 880 nM 0.0792083718945341 0.473079674996397 no 1581 0.468433442853998 1998 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3099 9120367 49.47 µM 0.0791860232408209 0.473088155011445 no 1582 0.468442330759777 2271 24824940 SGTC_2505 galangin 7.89 µM 0.0786060478671653 0.47330822620822 no 1583 0.468672988462249 2174 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_144 4161-2749 112.381 µM 0.0782094844503592 0.473458706576873 no 1584 0.468830708814307 2198 797501 YMR168C CEP3 SGTC_1378 2093-0007 380 nM 0.0773634756883985 0.473779746577881 no 1585 0.469167197924101 2192 3618014 SGTC_914 3820-6779 408 µM 0.0761959218444962 0.474222833138296 no 1586 0.469631613577844 2254 2893481 SGTC_1959 st077091 55.8 µM 0.0759292216753104 0.474324050318087 no 1587 0.469737704212426 2267 821356 YKL052C ASK1 SGTC_486 niguldipine 82 µM 0.0746007462198791 0.474828253557665 no 1588 0.470266190191026 2290 1236 A calcium channel blocker. SGTC_396 dithiazanine 1.25 µM 0.07435279058805 0.474922365944821 no 1589 0.470364836211912 2140 10578 An antihelmenthic. SGTC_1079 idarubicin 2.36 µM 0.0719022811403538 0.475852539395811 no 1590 0.471339837331636 2291 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.07171867880424 0.47592223721324 no 1591 0.471412895452086 2254 23847180 SGTC_2421 5690543 90.72 µM 0.0716485307760174 0.475948866505113 no 1592 0.471440808657666 2195 3397993 SGTC_2871 9038510 12.99 µM 0.0708702104722077 0.47624433628271 no 1593 0.471750526170693 2294 4945164 SGTC_2912 7964298 10.93 µM 0.0708154210349641 0.476265136212069 no 1594 0.471772329213508 2209 2975850 SGTC_1036 k216-0215 33.5 µM 0.0707073270517357 0.476306172545289 no 1595 0.471815344645897 2298 622330 SGTC_3281 9140613 49.47 µM 0.0701255332860118 0.476527046524481 no 1596 0.47204687205085 2090 16013766 SGTC_94 0334-0113 514.748 µM 0.0700370065580621 0.476560655718315 no 1597 0.472082102484149 2275 6795178 SGTC_2960 9079389 5.97 µM 0.0698045031735977 0.476648926478291 no 1598 0.472174631454673 2293 16457355 SGTC_904 1141-0088 396 µM 0.0697497552839363 0.476669711881598 no 1599 0.472196419596431 2120 1378119 SGTC_416 estradiol valerate 100 µM 0.0696008453261589 0.47672624686623 no 1600 0.472255682050619 2176 13791 A steroid. SGTC_2120 5538279 151.968 µM 0.0683254535476903 0.477210479724483 no 1601 0.472763281234975 2240 2058197 SGTC_3296 9122258 64.045 µM 0.0670296988298371 0.477702478314991 no 1602 0.473279030057071 2236 4730474 SGTC_2080 5212524 12.4 µM 0.0663719248068314 0.477952248429905 no 1603 0.473540860830454 2320 260183 SGTC_3137 9097352 49.47 µM 0.0652184483686989 0.47839026763807 no 1604 0.47400003636231 2245 44120435 SGTC_2673 kobusone 100 µM 0.065145784182456 0.478417861893801 no 1605 0.47402896366132 2290 6710676 An epoxy ketone and protein crosslinker. SGTC_3268 9137683 49.47 µM 0.0629728166405646 0.479243094463222 no 1606 0.474894075262244 2243 1953228 SGTC_1910 st062352 60.4 µM 0.0622442106757891 0.479519818818138 no 1607 0.475184177847572 2277 2245730 SGTC_1213 1315-0166 115 µM 0.0614381249538172 0.47982598146111 no 1608 0.475505145185343 2094 768401 SGTC_3347 9188721 44.724 µM 0.0607209587418181 0.480098381240215 no 1609 0.475790719907833 2219 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2622 2-methoxyxanthone 59.94 µM 0.0595084269139674 0.480558955805246 no 1610 0.476273576833612 2278 71034 A hepatoprotective. SGTC_3303 9125618 40.5795 µM 0.0591181267607656 0.480707215051187 no 1611 0.476429010412472 2246 22695467 SGTC_2376 9072922 81.32 µM 0.0576520186725659 0.481264153902482 no 1612 0.477012906817781 2254 17087968 SGTC_545 4218-0007 221 µM 0.0574634132933395 0.481335803182677 no 1613 0.477088024945571 2245 2840508 SGTC_1055 3448-0672 86 µM 0.0571114001958139 0.481469531016916 no 1614 0.477228227602014 2252 748378 SGTC_3354 9151612 71.43 µM 0.0557802928274721 0.481975230089023 no 1615 0.477758417271231 2295 27261949 SGTC_415 dibenzyl ketone 100 µM 0.0553027278820308 0.482156668207461 no 1616 0.477948644479308 2287 7593 SGTC_2914 7968218 45.32 µM 0.0545785220022875 0.482431818038213 no 1617 0.47823712510406 2282 2977111 SGTC_700 3453-2283 142 µM 0.0537188530561958 0.482758445631887 no 1618 0.478579580961032 2291 565664 SGTC_3152 9099253 49.47 µM 0.052746054615889 0.483128070245387 no 1619 0.478967121898509 2270 25236131 SGTC_2408 sulbentine 18.36 µM 0.052533365173611 0.483208885694541 no 1620 0.479051855232655 2181 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2448 5185112 27.17 µM 0.051766159624698 0.483500405924629 no 1621 0.47935751004461 2248 5718189 SGTC_100 0086-0128 49.5915 µM 0.0515182435334684 0.483594610155199 no 1622 0.479456282458374 2286 93297 SGTC_3332 9141069 11.198 µM 0.050643388567108 0.48392704861864 no 1623 0.479804844043692 2312 17332883 SGTC_1968 st069590 43.6 µM 0.0503844099859915 0.484025460731615 no 1624 0.479908029817916 2293 6384066 SGTC_1491 4138-0063 26.5 µM 0.0503330280817153 0.484044986021146 no 1625 0.479928502256455 2330 23883227 SGTC_1329 1447-1697 50.6 µM 0.0498896448883057 0.484213474650849 no 1626 0.480105164605491 2249 2840515 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.0494046089364645 0.48439779483951 no 1627 0.480298427624533 2277 279621 SGTC_1998 st075797 76.8 µM 0.0484795119885279 0.484749353338849 no 1628 0.480667046152289 2323 24208315 SGTC_260 nsc-65238 3.989 µM 0.0457966420453643 0.485768972796646 no 1629 0.481736167632033 2317 3246252 SGTC_3000 9075062 71.4286 µM 0.0452523893088627 0.485975826549618 no 1630 0.481953068179491 2272 17057871 SGTC_2244 6635614 200 µM 0.0452273778098139 0.485985332743506 no 1631 0.48196303611831 2237 836499 SGTC_378 3970-0959 8.33 µM 0.0450836097278513 0.486039975254868 no 1632 0.4820203328404 2289 6615653 SGTC_2102 5377816 72.7585 µM 0.0434572847631916 0.486658117112614 no 1633 0.482668507078366 2315 1379702 SGTC_1496 4469-0713 57.4 µM 0.0427298975185302 0.486934596616884 no 1634 0.482958423277544 2334 746691 SGTC_1666 st014829 29 µM 0.0422716886305985 0.487108764803491 no 1635 0.483141057152716 2317 3858230 SGTC_803 4488-1585 147 µM 0.0399132474627822 0.488005261843915 no 1636 0.484081144785823 2325 747204 SGTC_3198 9112019 49.47 µM 0.0391142282821014 0.488309001149885 no 1637 0.48439965856087 2316 45595555 SGTC_2204 7233102 200 µM 0.0388009341601921 0.488428098698414 no 1638 0.484524550022365 2303 2172480 SGTC_2316 5844804 197.44 µM 0.0387978293231085 0.488429278995403 no 1639 0.484525787741175 2325 776813 SGTC_3217 9129673 49.47 µM 0.0354398012913541 0.489705883111021 no 1640 0.485864523895845 2314 17248312 SGTC_131 0141-0277 33.849 µM 0.0351819409709656 0.489803917059384 no 1641 0.485967331166804 2329 1547771 SGTC_1753 st043925 64 µM 0.0329973487762363 0.490634484625878 no 1642 0.48683835093082 2336 670181 SGTC_2065 5221596 34.26 µM 0.0312580153879791 0.491295796939744 no 1643 0.487531886449849 2326 788581 SGTC_1561 5-methoxyflavone 52.9 µM 0.0311693327442362 0.491329515642861 no 1644 0.487567248475273 2355 94525 SGTC_1888 azatryptophan 97.5 µM 0.0304698123585855 0.491595487766615 no 1645 0.487846184222956 2253 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1978 st071761 42 µM 0.0304512567373131 0.491602543049138 no 1646 0.487853583411377 2207 5147680 SGTC_938 3126-1755 342 µM 0.0286993046947881 0.492268687840857 no 1647 0.488552205456861 2349 1777771 SGTC_941 3237-0776 460 µM 0.0283388662561836 0.492405740097447 no 1648 0.488695941123981 2343 760008 SGTC_1935 st074532 41.6 µM 0.027677219300311 0.492657325487442 no 1649 0.488959796553511 2326 2829742 SGTC_2663 amphotericin b 100 µM 0.0275626229419988 0.492700900036438 no 1650 0.489005496451359 2351 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1144 3486-0183 12.5 µM 0.0274856092886727 0.492730184045731 no 1651 0.489036208818137 2280 6744069 SGTC_636 0kpi-0074 126 µM 0.0272082420590637 0.492835651701064 no 1652 0.48914682096425 2331 616434 SGTC_1216 1165-0504 9.65 µM 0.0268859262199245 0.49295821149389 no 1653 0.489275359355177 2352 6304004 SGTC_475 α-linolenic acid 10 µM 0.0264495143540187 0.493124157073108 no 1654 0.489449400601549 2354 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2302 7771753 200 µM 0.0234602235967057 0.494260865144224 no 1655 0.490641583358296 2322 2203047 SGTC_317 4495-0002 170 µM 0.023384299634253 0.494289736645411 no 1656 0.490671864329762 2303 15991618 SGTC_794 k038-0031 316 µM 0.0216838792926063 0.494936360713251 no 1657 0.491350061605687 2365 6624242 SGTC_3221 9128209 49.47 µM 0.0209058059558603 0.495232245590848 no 1658 0.491660397577088 2360 16460723 SGTC_2455 5377712 9.75 µM 0.0201111692308799 0.495534431881682 no 1659 0.49197734509514 2301 2243908 SGTC_1201 1889-3372 45.9 µM 0.0193465054190276 0.495825222425119 no 1660 0.492282342450169 2322 5392199 SGTC_1692 fluoroquinolonic acid 71 µM 0.0192990832648268 0.495843256456352 no 1661 0.492301257620994 2334 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3271 9137798 49.47 µM 0.0192719207254277 0.495853586022221 no 1662 0.492312091891417 2366 6498326 SGTC_1138 3761-0006 1.03 µM 0.0181579026806891 0.496277235133189 no 1663 0.49275644294429 2362 12061087 SGTC_145 3737-0113 38.366 µM 0.018058732312464 0.496314948770843 no 1664 0.492795999711037 2374 6849351 SGTC_470 aa-861 153 µM 0.0180519436605387 0.49631753043796 no 1665 0.49279870754991 2374 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1983 st071813 46.9 µM 0.0172322256418464 0.496629263394389 no 1666 0.493125676828987 2282 11838595 SGTC_3311 9131146 2.8755 µM 0.0165843501321775 0.496875647327448 no 1667 0.493384104814057 2322 4900406 YPR165W RHO1 SGTC_306 1672-3436 11.6 µM 0.015728638730607 0.497201072059395 no 1668 0.493725439708926 2364 6797378 SGTC_1451 4152-0210 104 µM 0.0155162574055776 0.497281840399864 no 1669 0.493810157260138 2377 659563 SGTC_684 1140-0066 328 µM 0.0145247327485852 0.497658917352385 no 1670 0.494205673731878 2359 6813534 SGTC_3024 9090631 49.47 µM 0.0139960723478492 0.497859967845987 no 1671 0.494416557271618 2382 25236383 SGTC_1024 4507-0395 26 µM 0.0121328644512523 0.498568553124171 no 1672 0.495159806139559 2319 4201836 SGTC_838 0109-0203 71.4 µM 0.0121023399097871 0.498580161770831 no 1673 0.49517198277572 2385 759422 SGTC_169 k015-0017 16.025 µM 0.0117586537227121 0.4987108675498 no 1674 0.495309083968643 2364 1840002 SGTC_162 k030-0015 37.8 µM 0.0111304351827534 0.498949782921421 no 1675 0.495559690488987 2384 1809920 YMR134W ERG29 SGTC_1729 st035615 45.989 µM 0.00997138446426976 0.499390577958089 no 1676 0.496022059063296 2269 17385451 SGTC_1999 st074831 12.5 µM 0.00966974324253436 0.499505294353075 no 1677 0.496142390696962 2377 17112523 SGTC_165 k038-0023 64.381 µM 0.00923686143782829 0.499669922584718 no 1678 0.496315077833668 2390 46368543 SGTC_2329 6138490 200 µM 0.00750101765524437 0.499669922584718 no 1679 0.497007554973098 2365 720019 SGTC_1364 1653-0028 37.6 µM 0.00655636263419928 0.499310663230447 no 1680 0.497384408478509 2381 5718652 SGTC_2614 arthonioic acid 13.39 µM 0.00615571468459839 0.499158293977195 no 1681 0.497544240655511 2392 6710684 SGTC_76 0433-0009 400.328 µM 0.00488164922775224 0.498673758782406 no 1682 0.498052511459901 2333 2841569 SGTC_679 0422-0091 41.4 µM 0.00384394233695092 0.498279113666228 no 1683 0.498466492654856 2398 627384 YHR062C RPP1 SGTC_245 methotrexate 289.6 µM 0.00360543468303579 0.498188408237577 no 1684 0.498561642781951 2360 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1609 st001574 46.4 µM 0.00301132936842509 0.497962467992853 no 1685 0.498798655210374 2396 3960012 SGTC_2991 9074669 71.4286 µM 0.00278485910547283 0.497876340760023 no 1686 0.498889003393911 2397 17333109 SGTC_671 0560-0003 407 µM 0.00195107460518223 0.497559251219609 no 1687 0.499221634341608 2399 3238678 SGTC_2950 9072895 21.46 µM 0.0015064562574611 0.497390162789057 no 1688 0.499399011132639 2397 17332245 SGTC_1873 rapamycin 2 nM 0.00148707403656147 0.497382791737715 no 1689 0.499406743511382 2401 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2216 7189485 200 µM 0.00136242067944789 0.497335386134195 no 1690 0.499456472955423 2403 731273 SGTC_2870 9038528 12.99 µM 0.00114632669512552 0.497253205799706 no 1691 0.499542681914319 2390 6463316 SGTC_2968 9090663 33.37 µM 0.000796920300809938 0.497120327131985 no 1692 0.499682074831548 2399 25236811 SGTC_213 1246-0773 967 nM 0.000779495760419729 0.497113700616641 no 1693 0.499689026215267 2395 6251622 SGTC_2363 9053361 176 µM 0.00056326102585813 0.497031467077638 no 1694 0.499775291373765 2403 6469797 YMR079W SEC14 SGTC_1924 st058459 75.1 µM 0.00039588366530678 0.49696781396452 no 1695 0.499842065271914 2404 688683 SGTC_2565 isoliquiritigenin 100 µM 0.000387557687672716 0.496964647621955 no 1696 0.499845386856163 2400 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_748 act1.228 77.9 µM 0 0.496817260892502 no 1697 0.5 2405 4421505 YNR035C ARC35 SGTC_1302 1159-0335 255 µM -0.000187288794560998 0.496746035823533 no 1698 0.499925282581641 2406 649284 SGTC_2012 4023501 200 µM -0.00038210142280363 0.496671949585238 no 1699 0.499847563590751 2407 3477460 SGTC_3103 9120822 49.47 µM -0.000641401349146699 0.496573339338392 no 1700 0.499744117900664 2407 17141819 SGTC_2158 5657123 3.6195 µM -0.00235335941389727 0.495922297226364 no 1701 0.499061146295425 2408 2858827 SGTC_459 nigericin 15.3 µM -0.00239837770587827 0.495905177317522 no 1702 0.499043186646053 2415 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1476 4112-3294 3.34 µM -0.00258220769671002 0.495835269086709 no 1703 0.49896984931781 2414 704369 SGTC_1940 st075990 51.1 µM -0.00280334060017787 0.49575117519757 no 1704 0.498881630373049 2437 1084979 SGTC_1520 flindersine 88 µM -0.00421455058824582 0.495214515496023 no 1705 0.49831864255496 2416 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3306 9127676 59.7925 µM -0.00557025115132876 0.494698973250265 no 1706 0.497777802794897 2422 41905287 SGTC_49 0717-0965 32.132 µM -0.00607084094323118 0.494508612472695 no 1707 0.497578099746729 2466 5889349 YGL099W LSG1 SGTC_216 k038-0035 28.382 µM -0.0087100279125979 0.493505022644696 no 1708 0.496525245537379 2411 4444231 YPR107C YTH1 SGTC_3038 9091290 49.47 µM -0.011596308595118 0.492407519070968 no 1709 0.495373845888253 2433 25236843 SGTC_1427 4048-4900 550 nM -0.0124749276987097 0.492073436602284 no 1710 0.495023352977173 2443 24132586 SGTC_1066 ketoconazole 628 nM -0.0129614492137115 0.491888446064504 no 1711 0.49482927467337 2427 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2277 7947813 106.88 µM -0.0140196207901677 0.491486102558344 no 1712 0.494407163723985 2473 1246798 SGTC_1464 k208-0027 110 µM -0.0166030231716734 0.490503865068784 no 1713 0.493376656374634 2425 X1464 SGTC_3104 9120930 49.47 µM -0.0170691044877307 0.49032666187652 no 1714 0.493190743183934 2468 17014836 SGTC_3292 9120825 59.784 µM -0.0170929201041582 0.490317607277348 no 1715 0.493181243513525 2429 24824900 SGTC_1373 2887-0003 58.5 µM -0.0171921489036919 0.490279880950653 no 1716 0.493141662766129 2462 776948 SGTC_1804 st050076 49.1 µM -0.0180320137154413 0.489960571783458 no 1717 0.492806657153701 2448 3895976 SGTC_1180 1193-0155 285 µM -0.0200175834679997 0.489205701695399 no 1718 0.492014672898328 2469 2921347 SGTC_3118 9124250 49.47 µM -0.0201680608468201 0.489148495037241 no 1719 0.491954653226568 2492 1504786 SGTC_1446 4239-0190 62 µM -0.0202158508377973 0.489130326866858 no 1720 0.491935591664828 2452 1340085 SGTC_2197 6588183 93.1375 µM -0.0209456250273557 0.488852893735392 no 1721 0.49164451554354 2439 884136 SGTC_2796 7949634 45.45 µM -0.0214399933750901 0.488664956246783 no 1722 0.491447335394786 2437 2971588 SGTC_98 0074-0023 107.663 µM -0.0214534266344754 0.48865984953683 no 1723 0.491441977532 2475 3563821 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0222800144657838 0.488345622311771 no 1724 0.491112295535727 2474 75037 A free radical scavenger. SGTC_2126 5251174 33.877 µM -0.0223710315582316 0.488311022617995 no 1725 0.491075994017314 2449 790722 SGTC_1218 1348-1416 30.7 µM -0.023085151826913 0.488039556432813 no 1726 0.490791174828373 2443 6787668 SGTC_3127 9126946 49.47 µM -0.0259703793031172 0.486942821732607 no 1727 0.489640482185448 2492 27243249 SGTC_2857 9024691 58.44 µM -0.0267068940218768 0.486662872729625 no 1728 0.489346757230298 2496 16478292 SGTC_1673 st016611 27.3 µM -0.0267097589884559 0.486661783769511 no 1729 0.48934561468158 2496 5226799 SGTC_1696 st025591 34.7925 µM -0.0272894599199336 0.486441444271272 no 1730 0.48911443175236 2453 2787147 SGTC_852 0418-0143 439 µM -0.0282931854819397 0.486059946367251 no 1731 0.488714157811717 2456 5369229 SGTC_2401 5128683 200 µM -0.0283388579599861 0.486042587386506 no 1732 0.488695944432356 2477 708373 SGTC_1321 1326-2144 215 µM -0.0284909033429229 0.485984798882897 no 1733 0.488635311583209 2446 3513030 SGTC_310 1273-0058 1.06 µM -0.0305346699541083 0.485208045296655 no 1734 0.487820321819718 2465 2734232 SGTC_2469 5655019 90.81 µM -0.0308449924417761 0.485090109020399 no 1735 0.487696579347446 2478 2788239 SGTC_2172 5754775 163.918 µM -0.0309256059484678 0.485059472533913 no 1736 0.487664434546411 2473 2263357 SGTC_449 xestospongin c 11.1929 µM -0.0316763139427095 0.484774176521468 no 1737 0.487365092070631 2494 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1209 2323-2347 50.3 µM -0.031722484097807 0.484756630456459 no 1738 0.487346682095645 2456 5412760 SGTC_1821 st053465 65.6 µM -0.0321537103189563 0.484592752789549 no 1739 0.487174735443717 2485 675086 SGTC_1149 3909-7961 23.3 µM -0.0324475771535953 0.484481076906557 no 1740 0.487057560681005 2472 735261 SGTC_3167 9103034 49.47 µM -0.0329526924210838 0.484289124805992 no 1741 0.486856156555855 2459 5127859 SGTC_2969 9091408 28.7 µM -0.0333782369325457 0.484127413723972 no 1742 0.486686482201472 2505 4286311 SGTC_192 3455-0609 60.9 µM -0.0337436018883082 0.483988573544516 no 1743 0.486540804737593 2531 3769639 SGTC_2294 7971431 200 µM -0.0366678734018957 0.482877409757238 no 1744 0.485374912359672 2506 5741572 SGTC_1126 isoteolin 1.0172 µM -0.0382625974759729 0.482271502479092 no 1745 0.484739155912696 2474 133323 SGTC_533 1222-0222 6.71 µM -0.0393506374391873 0.481858130657744 no 1746 0.484305417507919 2625 3982874 SGTC_2976 9009005 19.48 µM -0.0396733974175977 0.481735510326532 no 1747 0.484176755379504 2476 2993148 SGTC_15 0266-0086 27.098 µM -0.0399075536333288 0.481646552692985 no 1748 0.484083414486774 2466 1712902 YIL048W NEO1 SGTC_740 k014-0057 261 µM -0.0409013134149245 0.481269026413809 no 1749 0.483687285185778 2536 4012779 SGTC_2876 9059903 25.97 µM -0.0415122287655311 0.48103694987022 no 1750 0.483443772056647 2478 6916095 SGTC_779 1360-0071 233 µM -0.0424263285492621 0.480689710648276 no 1751 0.483079420046953 2510 7566 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0424596491419696 0.480677053424904 no 1752 0.483066139021372 2486 803109 SGTC_2712 st079126 47.7 µM -0.0446920236371919 0.479829104438361 no 1753 0.482176395781293 2473 3152970 SGTC_2137 5261020 140 µM -0.044714849581713 0.479820434657016 no 1754 0.482167298641326 2488 763655 SGTC_1575 cyproterone acetate 48 µM -0.0448309675317922 0.479776330726916 no 1755 0.482121020689506 2499 9880 An androgen receptor antagonist and liver toxin. SGTC_2471 5466956 24.79 µM -0.0464511336505092 0.479160985158592 no 1756 0.481475340853978 2558 724419 SGTC_292 k038-0015 474 µM -0.0468092060859868 0.479024994466139 no 1757 0.481332645841216 2537 46368540 SGTC_3065 9113888 49.47 µM -0.0473994790459779 0.478800822736191 no 1758 0.481097422108172 2558 16648368 SGTC_2434 5670830 169.91 µM -0.0483832067124265 0.478427241136554 no 1759 0.48070542136595 2555 1549830 SGTC_441 propafenone 146 µM -0.0486173201575388 0.478338336713338 no 1760 0.480612133398548 2478 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1294 1000-1494 117 µM -0.0487365650964499 0.478293053942088 no 1761 0.480564617876781 2490 712797 YDL207W GLE1 SGTC_2627 acetyl isogambogic acid 100 µM -0.0492440862916448 0.478100328013471 no 1762 0.480362389041516 2548 6857789 A caspase activator and apoptosis inducer. SGTC_1091 telmisartan 47.6 µM -0.0495548090103312 0.477982336796933 no 1763 0.480238579770466 2576 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_23 0213-0011 39.996 µM -0.0497516638821211 0.47790758579124 no 1764 0.480160142789741 2527 627608 SGTC_2487 5918373 44.05 µM -0.0500264476223203 0.477803244431592 no 1765 0.48005065627444 2491 2876279 SGTC_2235 salicylic acid 500 µM -0.0507222811898812 0.477539028120428 no 1766 0.47977341083882 2482 338 A COX inhibitor and kinase inhibitor. SGTC_356 1634-0012 32.5 µM -0.0514105191873796 0.47727770564897 no 1767 0.479499201379832 2488 735457 SGTC_2333 9017922 200 µM -0.0517352784384865 0.477154398653388 no 1768 0.479369813369429 2543 3163164 SGTC_542 3381-0244 89.3 µM -0.0524843651567746 0.4768699882258 no 1769 0.479071376480744 2504 1112843 SGTC_1176 0848-0131 83.3 µM -0.0525165693632731 0.476857761316916 no 1770 0.479058546554911 2535 6769040 SGTC_3146 9095609 49.47 µM -0.0525486626767953 0.476845576532228 no 1771 0.479045760829635 2543 17173999 SGTC_2224 6650123 117.647 µM -0.0532633796348822 0.476574227437998 no 1772 0.478761028790754 2498 2908370 SGTC_2485 5633444 17.78 µM -0.0533782297700432 0.476530624500992 no 1773 0.478715275303263 2539 5724239 SGTC_351 caspofungin 25 nM -0.0544315378638159 0.476130748492602 no 1774 0.478295676254937 2527 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_934 2950-0684 338 µM -0.0544702021910161 0.476116070491209 no 1775 0.478280274269659 2530 1121253 SGTC_1243 0416-0003 5.65 µM -0.055004959443744 0.47591306582467 no 1776 0.478067256355917 2543 2141977 SGTC_1371 2421-0008 32.7 µM -0.056508745223679 0.47534223201487 no 1777 0.477468264488922 2558 2827552 SGTC_221 trifluoperazine 10.304 µM -0.0589221575651095 0.474426212219875 no 1778 0.476507054762755 2511 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1747 st037496 66.6 µM -0.0592307643225183 0.474309089003036 no 1779 0.476384153132006 2525 723305 SGTC_406 estrone 100 µM -0.0605544009584084 0.473806764391486 no 1780 0.475857044801596 2526 5870 A steroid. SGTC_1291 0993-0025 5.79 µM -0.0611121412732539 0.473595112467115 no 1781 0.475634949943592 2561 4353356 SGTC_1901 st060216 58.6 µM -0.061245505847295 0.473544504229966 no 1782 0.475581844651919 2516 688792 SGTC_2760 etidronate 98.04 µM -0.0635382258141039 0.472674546666204 no 1783 0.474668960462529 2549 3305 A chelator and antioxidant. SGTC_1861 st057647 17.4 µM -0.0636937888901349 0.472615523951533 no 1784 0.474607025227015 2609 688668 SGTC_2688 kanamycin b 96.69 µM -0.0648289111481716 0.472184861646376 no 1785 0.474155111047614 2552 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_540 1187-0821 17.3 µM -0.065483987352261 0.471936342277087 no 1786 0.473894327605675 2533 847520 SGTC_1432 4049-0298 68.4 µM -0.066038771166442 0.471725879848888 no 1787 0.473673478941736 2547 741646 SGTC_1893 st059353 36.1 µM -0.0680526650431795 0.470961957152335 no 1788 0.47287185538783 2577 3112488 SGTC_1928 4'-methoxychalcone 40.3 µM -0.0694832209725026 0.470419374553948 no 1789 0.472302494047888 2585 641818 SGTC_2122 5258151 111.688 µM -0.0699929415157613 0.470226060483476 no 1790 0.472099638857393 2564 2173356 SGTC_1426 4048-4480 71.7 µM -0.0710666335414546 0.469818880414123 no 1791 0.471672361789815 2546 14224343 SGTC_2124 5246320 200 µM -0.0715217595518968 0.469646290847687 no 1792 0.471491253642174 2613 579342 SGTC_1256 0570-0116 285 µM -0.0717463222170374 0.46956113593061 no 1793 0.471401895662376 2554 410638 SGTC_3082 9117008 49.47 µM -0.0718527502983859 0.469520778530631 no 1794 0.471359546300879 2577 41448529 SGTC_2066 5222451 176 µM -0.0720447115228394 0.469447987858036 no 1795 0.471283162812587 2532 2281147 SGTC_489 paxilline 115 µM -0.0724632228735942 0.469289294128864 no 1796 0.47111663619639 2581 105008 A toxic potassium channel blocker. SGTC_2696 st077691 74.316 µM -0.074029512022803 0.468695422395523 no 1797 0.470493451242252 2634 757133 SGTC_1811 st050069 61.5 µM -0.0781538147792178 0.467131994818731 no 1798 0.4688528500287 2553 3877702 SGTC_300 r073-0011 5.04 µM -0.0785915249209161 0.466966098384407 no 1799 0.468678764410723 2540 2735780 SGTC_1384 3089-0840 101 µM -0.0793075204487613 0.466694741444558 no 1800 0.46839401234611 2523 1069836 SGTC_1546 5-methoxyflavanone 78.7 µM -0.0794363100321185 0.466645932796552 no 1801 0.468342794324663 2580 147795 SGTC_3343 9148379 18.9835 µM -0.0796148332185002 0.46657827694828 no 1802 0.468271798732303 2599 1955036 SGTC_2129 girgensonine 121.053 µM -0.0798283596135389 0.466497357022828 no 1803 0.468186884292955 2604 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2112 5488546 200 µM -0.0799928517146731 0.466435020528308 no 1804 0.46812147062905 2547 600757 SGTC_1679 SEC14.276 6.7 µM -0.0801113453515956 0.466390116280695 no 1805 0.468074349732823 2656 1005053 YMR079W SEC14 SGTC_1944 st076371 56.9 µM -0.0805236155714828 0.466233886047167 no 1806 0.467910407353779 2556 24208455 SGTC_1 0258-0098 57.368 µM -0.0819908957293203 0.465677901064862 no 1807 0.467326976617902 2560 6790032 YDR047W HEM12 SGTC_746 1095-0025 46.6 µM -0.0833819089054954 0.465150877168067 no 1808 0.46677393650793 2592 6749286 SGTC_1794 st048918 76.9 µM -0.083617392565804 0.465061663680691 no 1809 0.466680319048661 2529 672303 SGTC_3056 9094900 49.47 µM -0.0848378032011606 0.464599336740875 no 1810 0.466195169627427 2608 25236784 SGTC_2519 cryptotanshinone 88.04 µM -0.0856787991074704 0.464280770878648 no 1811 0.465860878002383 2577 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2320 7373003 200 µM -0.086640669650065 0.463916446272695 no 1812 0.465478568862085 2595 5415828 SGTC_170 4197-0004 226 µM -0.0870195443378657 0.463772949417046 no 1813 0.46532798845039 2661 218692 SGTC_2737 bleomycin 30.5 nM -0.0871709185087365 0.463715618538447 no 1814 0.465267827504603 2570 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2348 9022543 33.42 µM -0.0871866679996078 0.463709653679342 no 1815 0.465261568197861 2648 3162678 YDL140C RPO21 SGTC_1721 st082152 9.2685 µM -0.0884280781810102 0.463239515883542 no 1816 0.464768222771251 2570 5296051 SGTC_2953 9074162 66.49 µM -0.0892052583338546 0.462945213981623 no 1817 0.464459393247377 2587 16451992 SGTC_3226 9131256 49.47 µM -0.0892489133721906 0.462928683329908 no 1818 0.464442046596899 2539 17178073 SGTC_2024 5144227 134 µM -0.089372456146989 0.462881902305076 no 1819 0.464392956333303 2644 3475211 SGTC_464 bw-b 70c 158 µM -0.089798666832159 0.462720516215342 no 1820 0.464223603812721 2693 5353454 SGTC_2799 7812892 81.82 µM -0.0903852950323792 0.462498397542011 no 1821 0.463990520862565 2618 20205235 SGTC_1512 0259-0544 12.2 µM -0.0904235773969624 0.462483902858608 no 1822 0.463975310691986 2573 18476 SGTC_1988 st071872 53.4 µM -0.0904682829153059 0.462466976267791 no 1823 0.463957548570554 2556 16414116 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.0908523741367576 0.462321552842608 no 1824 0.463804946773754 2672 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1023 4482-3888 16 µM -0.0910531364110963 0.46224554285692 no 1825 0.463725184809162 2613 3303168 SGTC_639 0833-0042 114 µM -0.0930252438099116 0.461498963077657 no 1826 0.462941753257732 2596 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3227 9130768 49.47 µM -0.0946901412756003 0.460868789115692 no 1827 0.462280474456844 2586 17720899 SGTC_894 0960-0238 55.9 µM -0.0947461170856731 0.460847603624693 no 1828 0.462258243287268 2540 6741907 YDL195W SEC31 SGTC_1559 coumarin 343 70.1 µM -0.0948726679927641 0.460799707575198 no 1829 0.462207983177783 2657 108770 A hepatotoxic, DNA x-linker. SGTC_553 k007-0256 45.7 µM -0.0961758662473419 0.460306515962662 no 1830 0.461690448945742 2629 6287000 SGTC_1057 3448-5381 134 µM -0.0973169318428651 0.459874733097799 no 1831 0.461237355077853 2684 5497911 SGTC_2588 indole-3-carbinol 100 µM -0.100814153119433 0.458551670314067 no 1832 0.459848995759426 2673 3712 Induces cell cycle arrest. SGTC_2011 4012611 177 µM -0.101281012052253 0.458375083450159 no 1833 0.459663694432946 2591 2049887 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.101751577223495 0.458197103034523 no 1834 0.459476930926902 2700 5282362 SGTC_1089 terbinafine 2.25 µM -0.102662367260469 0.457852641564675 no 1835 0.459115471176323 2688 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_841 0251-0215 91.2 µM -0.104466631226396 0.457170361302286 no 1836 0.458399523889601 2656 3888614 SGTC_45 0kpi-0036 14.9 µM -0.105517994092195 0.456772847765817 no 1837 0.457982396236568 2665 2795021 SGTC_598 3937-0236 20.2 µM -0.105888462094965 0.456632786482266 no 1838 0.457835424256969 2656 1379313 SGTC_1287 0971-0001 34.6 µM -0.106120331604042 0.456545127289896 no 1839 0.457743439971618 2587 4665869 SGTC_640 3381-0960 37.1 µM -0.106198137966641 0.456515712757959 no 1840 0.45771257414046 2641 1745025 SGTC_605 1315-0399 119 µM -0.106444905060223 0.456422424553616 no 1841 0.457614683173022 2696 24020461 SGTC_1473 k844-0725 134 µM -0.108779468085667 0.45553998238664 no 1842 0.456688704630239 2613 54682906 SGTC_635 k038-0028 24.7 µM -0.110042802899046 0.455062545255474 no 1843 0.456187714608723 2629 4035102 SGTC_2303 7774051 200 µM -0.110990258612362 0.454704527114203 no 1844 0.455812035752229 2700 2953184 SGTC_1400 3771-8998 51.5 µM -0.111773949994717 0.454408418917646 no 1845 0.455501321479449 2643 670767 SGTC_289 k017-0060 526 µM -0.113386219041058 0.453799322648197 no 1846 0.454862182431276 2620 5512909 SGTC_2288 7946289 167.31 µM -0.114301182885981 0.453453708310022 no 1847 0.454499522419393 2693 1246052 SGTC_1868 st057644 42.7 µM -0.1150073983221 0.453186969750056 no 1848 0.454219628972379 2585 688665 SGTC_720 r052-1644 49.9 µM -0.116145329638115 0.452757215980239 no 1849 0.453768682014087 2707 1422863 YOR257W CDC31 SGTC_1474 0330-0125 5.35 µM -0.117116223204056 0.452390589798624 no 1850 0.453383976974968 2652 X1474 SGTC_2084 5306078 60.6385 µM -0.117456841772449 0.452261975945435 no 1851 0.453249021260974 2690 679340 SGTC_56 0957-0365 83.25 µM -0.117732023842989 0.452158073857045 no 1852 0.453139995936305 2596 6752360 SGTC_1442 4112-3290 3 µM -0.117817737257996 0.452125711215323 no 1853 0.453106037566629 2612 704353 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.117849511263323 0.452113714448838 no 1854 0.453093449269309 2622 140250 A respiratory chain inhibitor. SGTC_2893 9048488 25.97 µM -0.118967382098746 0.451691672955701 no 1855 0.452650598765214 2650 6467338 SGTC_1206 3978-0017 132 µM -0.120379859612979 0.451158483642014 no 1856 0.452091122536125 2900 3873677 SGTC_1878 temozolomide 1 mM -0.120462164081567 0.451127417633154 no 1857 0.452058525014589 2606 5394 DNA alkylating agent. SGTC_840 0245-0196 390 µM -0.120955872344638 0.450941072616491 no 1858 0.451862993629241 2739 3827528 SGTC_1301 naphtanilide LB 4.81 µM -0.121584524492193 0.450703810097086 no 1859 0.451614035108498 2699 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1761 st044296 37 µM -0.121934211370551 0.450571840770876 no 1860 0.451475560509131 2600 1826700 SGTC_1094 duloxetine 25.4 µM -0.123824984211007 0.449858371648374 no 1861 0.450726924753939 2604 60834 A selective serotonin reuptake inhibitor. SGTC_2280 7785178 200 µM -0.12434250502871 0.449663117151807 no 1862 0.450522047135071 2649 2954328 SGTC_1358 1509-0022 2.48 µM -0.124687422709497 0.449532990546349 no 1863 0.450385507456765 2658 3258434 SGTC_566 0958-0068 16.5 µM -0.125582790950835 0.449195221600202 no 1864 0.450031092963566 2740 6815365 SGTC_431 k089-0097 107 µM -0.125688467298875 0.449155358651547 no 1865 0.44998926561433 2617 5499420 SGTC_2819 7996655 46.38 µM -0.125817617070106 0.449106641818028 no 1866 0.449938148094079 2712 6456960 SGTC_621 3584-0052 32.1 µM -0.125877556940489 0.449084032044904 no 1867 0.449914424156602 2629 2273927 SGTC_724 3910-0327 137 µM -0.12613654850547 0.448986340366356 no 1868 0.449811918491237 2675 2885483 SGTC_930 2810-3379 265 µM -0.12813137223486 0.448233996475082 no 1869 0.449022504607364 2803 1015764 SGTC_872 0588-0139 234 µM -0.129402424150506 0.447754718637641 no 1870 0.448519614807562 2656 2047100 SGTC_644 1498-1197 63.3 µM -0.129600360374699 0.447680089314183 no 1871 0.448441309057338 2725 6741615 SGTC_2496 diffractaic acid 79.83 µM -0.129958844747253 0.4475449320799 no 1872 0.448299493806964 2849 94870 An apoptosis inducer which activates caspases. SGTC_2170 morpholine 200 µM -0.130179317745518 0.447461811478318 no 1873 0.448212278686788 2738 121171 Reacts with secondary amines. SGTC_271 rotenone 740 µM -0.130380079543772 0.447386124210121 no 1874 0.448132863137242 2772 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2164 5685496 200 µM -0.130812072641626 0.447223269161392 no 1875 0.447961986239239 2638 759046 SGTC_26 0302-0163 425.158 µM -0.13188607079746 0.44681842625999 no 1876 0.447537203138177 2640 3100915 SGTC_2074 5212007 75.395 µM -0.134972522445929 0.445655300236036 no 1877 0.446316799706751 2642 758611 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.135612556819746 0.445414162165121 no 1878 0.446063789128682 2983 5282309 SGTC_184 1494-0393 24.714 µM -0.136035775098292 0.445254722378306 no 1879 0.445896499698307 2633 3090647 SGTC_2453 5731132 22.18 µM -0.136480175841554 0.445087312014461 no 1880 0.445720847644536 2754 1362040 SGTC_1428 4049-0204 61.7 µM -0.139668283922989 0.443886607574908 no 1881 0.444461043248305 2755 X1428 SGTC_2096 5468907 200 µM -0.139916645775309 0.443793091075345 no 1882 0.444362924617762 2790 759785 SGTC_1965 Pectolinarigenin 58.4 µM -0.140071393452895 0.44373482500904 no 1883 0.444301791227218 2676 5320438 An anti-inflammatory. SGTC_3337 9144342 33.5465 µM -0.140880892572812 0.443430049789232 no 1884 0.443982018552264 2755 17682949 SGTC_1022 4477-0945 21.3 µM -0.143081087079893 0.442601849396351 no 1885 0.443113070785498 2674 4648966 SGTC_1650 st011916 45.8 µM -0.14376906274315 0.442342931899087 no 1886 0.442841416693722 2693 242528 SGTC_503 tyrphostin 8 294 µM -0.1444239483165 0.442096490630653 no 1887 0.442582853514524 2684 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1485 3909-9022 254 µM -0.144704232058138 0.441991023350874 no 1888 0.442472198815997 2670 714516 SGTC_3254 9136651 49.47 µM -0.144997698580124 0.441880599961911 no 1889 0.442356344427596 2662 16454030 SGTC_2127 5253358 187.912 µM -0.145137674126384 0.441827932600136 no 1890 0.442301086772369 2650 20612 SGTC_2145 5634607 200 µM -0.146011263538925 0.441499258105948 no 1891 0.441956248352796 2646 308662 SGTC_291 SEC14.278 35.5 µM -0.146156530482952 0.441444607566758 no 1892 0.441898910314011 2728 1068044 SGTC_3259 9138485 49.47 µM -0.148449531208219 0.440582111448071 no 1893 0.440994006404997 2874 17646153 SGTC_2281 7943571 200 µM -0.148663353134713 0.440501698134059 no 1894 0.44090963989633 2759 1244024 SGTC_1697 st025554 27.742 µM -0.149441999826324 0.440208888491815 no 1895 0.440602436365755 2658 1269519 SGTC_1573 oleylamine 1.06 µM -0.150399489623433 0.439848869841267 no 1896 0.440224721956178 2648 5356789 An amine of the fatty acid oleic acid. SGTC_1443 4112-3303 14 µM -0.15094463578661 0.439643915667602 no 1897 0.440009694791502 2684 704433 SGTC_1789 tunicamycin 25 nM -0.151084504492775 0.439591332971893 no 1898 0.439954527902561 2774 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_815 1582-0027 36.9 µM -0.15300857785184 0.438868099143765 no 1899 0.439195755399747 2751 3128206 SGTC_318 1488-0629 67.2 µM -0.153356192256267 0.438737457161726 no 1900 0.439058694839668 2752 3662576 SGTC_1851 st056236 18.9 µM -0.153613392131054 0.438640799463099 no 1901 0.438957288442367 2685 5393171 SGTC_1435 4092-0789 56.7 µM -0.153617530289106 0.438639244341252 no 1902 0.438955656920262 2721 2248285 SGTC_955 1216-0110 33 µM -0.154812860119036 0.438190078551854 no 1903 0.438484426268782 2647 3619719 SGTC_826 1683-5028 118 µM -0.155666132571677 0.437869495384105 no 1904 0.438148096986024 2762 722377 SGTC_1146 3579-1023 7 µM -0.156937205503331 0.437392015985302 no 1905 0.437647168701533 2809 X1146 SGTC_586 0957-0265 8.15 µM -0.157750710224335 0.437086470192793 no 1906 0.437326619875097 2678 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1309 pyrazolanthrone 13.4 µM -0.15779792053615 0.437068739531781 no 1907 0.437308018650096 2757 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2128 5255449 168.493 µM -0.158332064799219 0.436868141094853 no 1908 0.437097571376023 2707 736008 SGTC_1614 st002383 48.6 µM -0.158555109326792 0.436784381290243 no 1909 0.43700969942029 2698 1947235 SGTC_1723 st034307 2.5525 µM -0.158785481512783 0.436697872708734 no 1910 0.436918943878819 2761 867466 SGTC_2701 st077767 14.721 µM -0.159067594478824 0.436591938728981 no 1911 0.436807809485358 2709 5721188 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.159581273034855 0.436399063092829 no 1912 0.436605465932204 2660 6708630 An antioxidant. SGTC_525 k781-2675 26.7 µM -0.161155628105151 0.435808019824691 no 1913 0.435985413939061 2677 3651118 YDL195W SEC31 SGTC_2790 5423970 71.43 µM -0.161345079930434 0.435736905590667 no 1914 0.435910809844016 2834 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2429 5902844 64.44 µM -0.161517010506171 0.435672370078995 no 1915 0.435843107402684 2839 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2620 irigenin 100 µM -0.161710510701286 0.435599740287714 no 1916 0.435766913573141 2838 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1929 genistein trimethyl ether 50.5 µM -0.161930280293422 0.435517252981728 no 1917 0.435680378635678 2713 136420 SGTC_806 3966-4455 5.86 µM -0.162093242494612 0.435456089311339 no 1918 0.435616213767281 2705 714982 SGTC_1460 k062-0059 9.15 µM -0.162415032500887 0.435335318245793 no 1919 0.435489516890262 2611 1373085 SGTC_3028 9087778 49.47 µM -0.167420949655132 0.43345733021217 no 1920 0.433519421185335 2705 17217395 SGTC_2460 5552655 174.22 µM -0.168089197117467 0.433206747413907 no 1921 0.433256553942689 2822 5401989 SGTC_364 0083-0097 67.7 µM -0.168126140684822 0.433192894911337 no 1922 0.43324202238155 2833 5207356 SGTC_3314 9135860 59.4275 µM -0.168978431186683 0.432873339600118 no 1923 0.432906803420233 2727 25252478 SGTC_611 3453-1652 23.7 µM -0.17054391804485 0.43228649503003 no 1924 0.432291199305838 2770 1560575 SGTC_2225 6654152 15.4 µM -0.172038639116321 0.4317263173607 no 1925 0.431703576109736 2703 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.172048426715702 0.431722649706311 no 1926 0.431699728784383 2848 5377381 SGTC_432 NS 1619 61.3 µM -0.172150846192415 0.431684270960639 no 1927 0.431659469959937 2888 4552 A K+/calcium channel activator. SGTC_548 1436-0017 110 µM -0.172419861374105 0.431583468350375 no 1928 0.431553729441068 2805 9677137 SGTC_993 3909-8757 62.7 µM -0.173669801230659 0.431115162247525 no 1929 0.431062485975619 2759 4288324 YLR208W SEC13 SGTC_2693 st077581 40.7 µM -0.173833278415791 0.431053920555865 no 1930 0.430998245073851 2756 25238761 SGTC_2767 sibutramine 71.45 µM -0.173993234589533 0.430993999507166 no 1931 0.430935389575245 2837 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2848 9016370 25.97 µM -0.174505072782384 0.430802270908982 no 1932 0.430734272215311 2746 7894410 SGTC_1045 1348-1485 165 µM -0.17574965043887 0.430336134808286 no 1933 0.430245313466601 2696 6810614 SGTC_2647 atorvastatin 60.16 µM -0.177012816425719 0.429863136001897 no 1934 0.429749161249467 2797 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1693 xanthone 101.9 µM -0.177768288159907 0.429580293895965 no 1935 0.429452476505368 2756 7020 An insecticide. SGTC_890 0929-0006 47.2 µM -0.178057097186265 0.429472175827467 no 1936 0.429339067515764 2730 1378169 SGTC_1164 k060-0068 93.7 µM -0.179085632668955 0.429087178009417 no 1937 0.42893523155173 2712 5963676 SGTC_655 k060-0012 42 µM -0.179678090185813 0.428865441969589 no 1938 0.428702647494661 2740 5994525 SGTC_2406 ethylparaben 405.7 µM -0.18236374011491 0.427860580063826 no 1939 0.427648639907882 2705 8434 A possible steroid mimic. SGTC_1545 lovastatin 49.4 µM -0.182578183126357 0.427780364213669 no 1940 0.427564501962301 2772 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_973 1325-0077 65.9 µM -0.184149012041266 0.427192861668916 no 1941 0.426948278911607 2798 2835149 SGTC_1450 4112-4260 37.6 µM -0.1843446474056 0.427119703760904 no 1942 0.426871545244405 2757 1633175 SGTC_1800 st050079 29.0735 µM -0.18526031253126 0.426777323850132 no 1943 0.426512432579439 2821 3645560 SGTC_205 1486-1330 71.903 µM -0.187136953232156 0.426075794471506 no 1944 0.425776627713367 2723 4118834 SGTC_2347 9049783 174.81 µM -0.188390358854765 0.425607374136936 no 1945 0.42528532845382 2885 6467988 YPL169C MEX67 SGTC_1846 st056244 14.8 µM -0.188394151291258 0.425605956993835 no 1946 0.425283842102509 2815 5393182 SGTC_2295 7971645 200 µM -0.18844543011027 0.425586795416074 no 1947 0.425263744746991 2814 2978226 YKL099C UTP11 SGTC_610 4215-0184 155 µM -0.18942855941669 0.425219459277717 no 1948 0.424878471240667 2813 5605015 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.189587725331298 0.425159994670058 no 1949 0.424816103264323 2711 688667 SGTC_12 0849-0099 9.267 µM -0.190699698601458 0.424744607477657 no 1950 0.42438043741955 2724 6071388 SGTC_768 0384-0033 77.3 µM -0.192409941033949 0.424105894918773 no 1951 0.423710553034592 2758 3965305 YMR134W ERG29 SGTC_820 1582-0060 59.9 µM -0.192899126988879 0.423923238562527 no 1952 0.42351898437778 2795 3848840 SGTC_693 4161-2696 114 µM -0.193822549683962 0.423578487820634 no 1953 0.423157414864913 2859 805759 SGTC_1425 4048-4433 7.33 µM -0.195266622531816 0.423039474838354 no 1954 0.422592112723353 2803 23734946 SGTC_3025 9087895 49.47 µM -0.195861347244911 0.422817530386275 no 1955 0.422359345840967 2861 17173641 SGTC_1977 st070720 65.3 µM -0.196755421380414 0.422483918274653 no 1956 0.422009468848978 2861 682188 SGTC_916 4466-0038 42 nM -0.203711099654569 0.419890414284635 no 1957 0.419289633904523 2896 5722064 YGL116W CDC20 SGTC_2160 5660466 132.927 µM -0.204968041543552 0.419422116636029 no 1958 0.418798547027419 2727 2859134 SGTC_2370 9071495 200 µM -0.206833853569241 0.418727183409421 no 1959 0.418069808228251 2850 21791103 SGTC_2482 5981709 142.65 µM -0.208123732451031 0.418246908137243 no 1960 0.417566178526874 2842 877755 SGTC_2201 6605497 169.863 µM -0.208653388144629 0.418049730664429 no 1961 0.417359415007794 2806 670741 SGTC_1133 3473-0247 50 µM -0.209252623611817 0.417826675229351 no 1962 0.417125516944264 2851 711311 SGTC_2805 7950783 58.44 µM -0.210257518899181 0.417452679038891 no 1963 0.416733344577217 2898 1178958 YDL195W SEC31 SGTC_2873 9040596 71.43 µM -0.21041154736812 0.417395360193636 no 1964 0.416673240444301 2879 6463863 SGTC_1020 4335-0961 93.3 µM -0.211434848199905 0.417014602343841 no 1965 0.416273983205327 2738 669075 SGTC_2218 6965428 192.983 µM -0.212265875840192 0.416705444265648 no 1966 0.415949807973959 2771 675684 SGTC_2549 cedrol 20.94 µM -0.212551737094377 0.416599110342747 no 1967 0.415838309681012 2952 6708665 A sedative which affects the nervous system. SGTC_1703 st026983 48.3 µM -0.21316976923206 0.416369237230731 no 1968 0.415597273497732 2926 1104023 SGTC_1393 3470-5649 58.2 µM -0.213205584090687 0.416355916998463 no 1969 0.415583306463898 2876 4108395 SGTC_1889 st059080 5.18 µM -0.213458904058093 0.41626170519146 no 1970 0.41548452010533 2841 176925 Isolated from Daphnopsis sellowiana. SGTC_652 0437-0092 114 µM -0.214006606922768 0.416058026384229 no 1971 0.415270952479394 2786 3091274 SGTC_1818 st052136 56.3 µM -0.214527239601827 0.415864435289538 no 1972 0.415067963627385 2854 674169 SGTC_3308 9128332 17.569 µM -0.21558328678172 0.41547181940467 no 1973 0.414656292341724 2934 17332805 YDL196W YDL196W SGTC_397 arbidol 50 µM -0.21791561199454 0.414605009975446 no 1974 0.413747431418024 2934 131410 A RNA synthesis inhibitor. SGTC_2758 dehydroepiandrosterone 69.35 µM -0.220555523241 0.413624387784425 no 1975 0.412719267743167 2866 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2 0422-0095 29 µM -0.221601185510184 0.413236114316248 no 1976 0.412312179767646 2780 6790840 SGTC_2415 st077333 57.7 µM -0.224109793948737 0.412304968875159 no 1977 0.411335935914845 3056 2766255 SGTC_1962 st076595 64.5 µM -0.224667173527461 0.412098147496792 no 1978 0.411119101751664 2795 279619 SGTC_2934 9036370 36.88 µM -0.225914980394096 0.411635224611089 no 1979 0.410633773168216 2915 6462800 SGTC_2458 5808907 16.39 µM -0.225957707529854 0.411619375478539 no 1980 0.410617157068842 2946 2731747 SGTC_2059 5238311 157 µM -0.225961747560931 0.411617876883605 no 1981 0.410615585954795 2805 703021 SGTC_859 0439-0102 54.6 µM -0.227072541739488 0.411205891775913 no 1982 0.410183667449946 2863 610143 SGTC_3030 9087619 49.47 µM -0.230948138888553 0.40976923183308 no 1983 0.408677546015775 2859 25236973 SGTC_166 k072-0058 166.424 µM -0.231046617012196 0.409732742290726 no 1984 0.408639293244832 2870 5846229 SGTC_1702 st027038 51 µM -0.232171241031911 0.409316085811967 no 1985 0.408202506917082 2869 5521182 SGTC_882 0843-0131 351 µM -0.232467262975505 0.409206431091381 no 1986 0.408087555574452 2808 5425421 SGTC_57 miconazole 162.5 nM -0.232479895166458 0.409201751936232 no 1987 0.40808265041364 2768 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_945 3381-0768 11.3 µM -0.233213120623831 0.408930176294314 no 1988 0.407797958971741 2953 1126236 YIL048W NEO1 SGTC_3287 9117173 37.0625 µM -0.233685670087748 0.408755174261946 no 1989 0.407614506692527 2876 2789709 SGTC_986 1493-0483 84 µM -0.236566280687736 0.407688775379447 no 1990 0.406496640912847 2881 40079 SGTC_1359 1582-0056 520 nM -0.237744707246738 0.407252719741296 no 1991 0.406039553132898 2934 3661189 SGTC_146 3448-8650 53.125 µM -0.238348897751267 0.407029194398203 no 1992 0.405805249496558 2855 2891488 YIL048W NEO1 SGTC_2869 9037858 32.47 µM -0.238600371630875 0.406936168447509 no 1993 0.405707738465141 2782 27187042 SGTC_1937 st074714 47.2 µM -0.240204877438011 0.406342748811311 no 1994 0.405085716356104 2793 17250970 SGTC_670 4204-0025 119 µM -0.24026602631335 0.40632013740594 no 1995 0.405062015376031 2943 719039 SGTC_2492 derrusnin 100 µM -0.241049620517747 0.406030410511722 no 1996 0.404758329264955 2768 1715307 Part of coumarin class of compounds. SGTC_1298 1079-1278 263 µM -0.24105609772097 0.40602801583842 no 1997 0.404755819229089 2845 2840950 SGTC_536 3852-0578 10.6 µM -0.241076500381655 0.406020472836247 no 1998 0.404747912846906 2992 2869208 SGTC_2854 9024559 71.43 µM -0.241432116139038 0.405889004882049 no 1999 0.404610111868883 2922 3163529 SGTC_2200 6600604 21.907 µM -0.242856210139247 0.405362636599672 no 2000 0.404058394671974 2838 2904777 SGTC_1320 1313-0481 95.3 µM -0.243260781598916 0.405213131584528 no 2001 0.403901691854885 2984 6813365 YLR208W SEC13 SGTC_1154 4088-0362 150 µM -0.244236952669641 0.404852455090517 no 2002 0.403523654685394 2810 6618304 SGTC_2913 7966556 36.57 µM -0.244654654645151 0.404698146890857 no 2003 0.403361920721772 2933 2976516 SGTC_2808 7946468 45.46 µM -0.245472626688263 0.404396013165464 no 2004 0.403045250315386 2926 2970879 SGTC_3007 9078383 71.4286 µM -0.245790861940226 0.404278482240661 no 2005 0.402922065612162 2873 6496995 SGTC_766 1391-0721 126 µM -0.246167343608308 0.404139450853655 no 2006 0.402776346925777 3013 1020919 YIL115C NUP159 SGTC_2835 9006588 71.43 µM -0.246185185936815 0.404132862138155 no 2007 0.4027694413185 3084 2345538 SGTC_325 2810-4341 181 µM -0.246269465358377 0.40410174027133 no 2008 0.402736822634788 2955 774970 SGTC_829 1635-0120 117 µM -0.247165275991979 0.403770981776534 no 2009 0.402390158725622 2982 285054 SGTC_2107 5363541 170.161 µM -0.24747317913665 0.403657311146934 no 2010 0.402271023007569 2888 244052 SGTC_2403 6032726 181.2 µM -0.247838565206168 0.403522429726118 no 2011 0.402129657432596 2920 2881040 SGTC_1313 1220-0047 237 µM -0.249093705558117 0.403059185075184 no 2012 0.401644149136886 2892 3528706 SGTC_865 0488-0499 301 µM -0.249453444834651 0.402926438285973 no 2013 0.401505024202036 2846 9634651 SGTC_212 3807-4682 38.772 µM -0.250525229807 0.402531007085081 no 2014 0.401090598039058 2916 3125501 YBL034C STU1 SGTC_1979 st071809 45.3 µM -0.25096401870007 0.402369146247119 no 2015 0.400920963993759 2983 4976333 SGTC_87 0100-0052 35.5 µM -0.251693741437306 0.402100002548749 no 2016 0.400638897455883 2898 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1183 1254-0324 198 µM -0.253190983154531 0.401547920203718 no 2017 0.400060316981685 2996 5799357 SGTC_1740 st038286 13.222 µM -0.253750936265317 0.401341497460916 no 2018 0.399843990070693 3068 716786 SGTC_1396 3511-0007 98.6 µM -0.254235464231095 0.401162901879462 no 2019 0.399656826988268 2978 X1396 SGTC_3284 9108171 64.8615 µM -0.255193125544732 0.40080997151454 no 2020 0.399286970180134 2974 8687505 SGTC_313 3474-0040 5.03 µM -0.256002468069261 0.400511764705116 no 2021 0.398974465781606 2836 1043375 YIL048W NEO1 SGTC_113 0099-0221 2.5 µM -0.256173574798863 0.400448726886287 no 2022 0.398908406110594 3037 89219 SGTC_1346 1488-2224 62.4 µM -0.256825519719446 0.40020856615281 no 2023 0.39865673439506 2940 3722427 SGTC_2097 5376186 200 µM -0.257137106232592 0.400093798541148 no 2024 0.398536466850881 3002 742755 SGTC_613 3914-0030 117 µM -0.257242657070075 0.400054922634867 no 2025 0.398495728054866 2799 1145395 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.257458250289276 0.399975519599358 no 2026 0.398412520327152 2883 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1836 st055642 81 µM -0.257874580854319 0.399822196656335 no 2027 0.398251851537095 2869 8571 SGTC_940 3232-1287 54.8 µM -0.259570011216511 0.399197976652149 no 2028 0.397597735586393 2862 1585493 YIL048W NEO1 SGTC_3245 9134821 49.47 µM -0.260864323800815 0.398721612690677 no 2029 0.397098568977863 2877 17014901 SGTC_372 0155-0182 15.9 µM -0.261633084538791 0.398438746279663 no 2030 0.396802167230629 2856 771486 SGTC_1971 st069429 63.5 µM -0.264279015926816 0.397465581436796 no 2031 0.395782464251469 3027 1246522 YGL099W LSG1 SGTC_402 epigallocatechin gallate 10 µM -0.264445739349553 0.397404282411089 no 2032 0.395718235302951 2890 65064 An antioxidant. SGTC_1912 st060209 90.8 µM -0.267401076083135 0.396318118711405 no 2033 0.39458018550102 2942 688787 SGTC_788 1182-0090 188 µM -0.269741049234378 0.395458687282911 no 2034 0.393679738973734 3082 5715185 SGTC_1503 4585-0012 61.3 µM -0.269872715178702 0.395410343734739 no 2035 0.393629089361273 3068 2922052 SGTC_202 3594-0513 34.79 µM -0.270844638357884 0.395053534283896 no 2036 0.393255263046391 2862 708429 SGTC_870 0573-2213 57.6 µM -0.271418937954269 0.394842740516713 no 2037 0.393034419075995 2865 3916321 SGTC_2794 7785382 27.27 µM -0.271688762437105 0.394743713426401 no 2038 0.392930671333349 2920 2205081 SGTC_2666 tannic acid 100 µM -0.273982367905891 0.393902222617343 no 2039 0.39204908587818 2972 16134267 A thiamine antagonist. SGTC_511 blebbistatin 171 µM -0.274005956781252 0.393893570764426 no 2040 0.392040021970991 3026 3476986 A myosin inhibitor. SGTC_3234 9132280 49.47 µM -0.27408954267998 0.393862913815097 no 2041 0.392007904979747 2966 17612295 SGTC_953 1188-0045 9.7 µM -0.274572789465352 0.39368568542844 no 2042 0.39182223698033 3005 6144426 SGTC_1018 4259-0013 28.1 µM -0.274592270822039 0.39367854119801 no 2043 0.391814752574564 3038 6801262 SGTC_2653 dihydrofissinolide 100 µM -0.275108042790689 0.393489409602454 no 2044 0.391616616329828 2946 6857746 SGTC_2357 9067248 200 µM -0.277214619693338 0.392717197318848 no 2045 0.390807657242705 2978 9150235 SGTC_3338 9144300 39.5675 µM -0.277405375500047 0.39264729236216 no 2046 0.390734427243723 2966 4901274 SGTC_383 2324-0395 7.37 µM -0.27879284317639 0.392138941042878 no 2047 0.390201903553913 3032 3146421 SGTC_2177 5811945 192 µM -0.279000078832427 0.392063028189593 no 2048 0.390122382133234 3055 5343475 SGTC_2983 9022671 12.99 µM -0.280045666418331 0.391680079894495 no 2049 0.389721234630794 3095 6405161 SGTC_2290 7904846 200 µM -0.280707715595363 0.391437657450468 no 2050 0.389467295208349 2956 2962154 SGTC_1660 st012960 28.1 µM -0.280900681745396 0.391367006996152 no 2051 0.389393288869366 2991 24207266 SGTC_1931 st074438 57.1 µM -0.280996965150905 0.391331756213803 no 2052 0.389356363777035 2835 2787313 SGTC_1791 st048313 56.1 µM -0.281239685364738 0.391242896706191 no 2053 0.389263283984949 3034 1204976 SGTC_2924 9010168 62.78 µM -0.281880438200253 0.391008345332978 no 2054 0.389017594813235 3000 2993929 SGTC_287 k060-0039 29.6 µM -0.281942669994163 0.390985567126508 no 2055 0.388993735123101 3034 5861974 SGTC_218 alverine citrate 93.75 µM -0.282835637587572 0.390658762549841 no 2056 0.388651417198353 3035 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2103 5378138 10 µM -0.283564118654109 0.390392213252971 no 2057 0.388372218978044 2912 244142 SGTC_2185 6113692 200 µM -0.283711356829781 0.390338345447389 no 2058 0.388315795361659 3037 874150 SGTC_1677 st019204 53.9 µM -0.28458266909812 0.390019614722232 no 2059 0.387981945256642 3012 3945625 SGTC_214 4373-3496 70 µM -0.28458471031345 0.390018868121375 no 2060 0.387981163246126 2945 3779166 SGTC_2261 9010538 184.68 µM -0.284688764324059 0.389980809561343 no 2061 0.387941299689953 3024 6457250 SGTC_1237 0330-0133 46.1 µM -0.286066214076709 0.389477096171174 no 2062 0.387413703973616 2888 X1237 YHR072W ERG7 SGTC_350 k064-0020 19.8 µM -0.286114112530153 0.389459583736531 no 2063 0.387395361471396 3110 2790705 SGTC_3173 9105693 49.47 µM -0.286573619633094 0.389291592059467 no 2064 0.387219408024539 3073 17096658 SGTC_2791 5663188 71.43 µM -0.286702630759194 0.3892444304669 no 2065 0.387170011532603 3076 54690634 SGTC_634 1611-4317 11.2 µM -0.288672220913416 0.388524625707072 no 2066 0.386416111295598 2932 2843522 SGTC_1250 0485-0349 40.2 µM -0.290410213647801 0.387889778029278 no 2067 0.385751215441105 2938 6842794 YDL195W SEC31 SGTC_593 1203-0218 61.7 µM -0.291352345733945 0.387545764524492 no 2068 0.385390928433529 3057 3666956 SGTC_3062 9077494 49.47 µM -0.293451200244459 0.38677969895338 no 2069 0.384588647446643 3054 16459633 SGTC_1434 4073-0095 163 µM -0.294001459119025 0.386578931574592 no 2070 0.384378394203183 2950 24133745 SGTC_1848 st056003 16.4 µM -0.294716324274887 0.386318151310285 no 2071 0.384105295904041 2975 146492 SGTC_1265 0819-1001 68.8 µM -0.295078136757539 0.386186182966226 no 2072 0.383967095429172 2915 3106768 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.295158513196838 0.386156868059721 no 2073 0.383936396273755 2952 368090 SGTC_2356 9061756 188.97 µM -0.295562677642729 0.38600947099866 no 2074 0.383782039851365 2996 20104043 SGTC_2264 7948757 110.76 µM -0.296202874638439 0.385776027546542 no 2075 0.383537576824676 2871 2971411 SGTC_2877 9040724 71.43 µM -0.297497471051008 0.385304088298319 no 2076 0.383043369227757 3130 6463895 SGTC_1355 1499-0035 1.68 µM -0.297894232036845 0.385159484843763 no 2077 0.382891945189828 2931 1548538 SGTC_417 st075190 100 µM -0.298620464212079 0.384894843739436 no 2078 0.382614824673597 3063 222757 SGTC_2841 9004761 38.96 µM -0.299311538207419 0.384643064157474 no 2079 0.382351175846778 2955 2991039 SGTC_2304 7443016 91.4 µM -0.299595759157965 0.384539527806666 no 2080 0.382242759687315 2863 939854 SGTC_2440 5628896 157.78 µM -0.299822538630002 0.384456922213607 no 2081 0.382156261216587 2943 5522048 SGTC_2636 apigenin dimethyl ether 100 µM -0.301154952517053 0.383971689661962 no 2082 0.381648169393555 3079 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2214 7179297 48.276 µM -0.30212073798888 0.383620087832964 no 2083 0.381280012029192 2943 769744 SGTC_3288 9119690 36.221 µM -0.303690543341328 0.383048792327383 no 2084 0.38068183163482 2966 17595618 YKL019W RAM2 SGTC_2851 9015922 71.43 µM -0.303811483965963 0.383004789229743 no 2085 0.380635758554117 3124 2996893 SGTC_2399 5884133 200 µM -0.3041733274218 0.382873144942836 no 2086 0.380497922158018 2949 722445 SGTC_101 0490-5701 117.494 µM -0.305322990544988 0.382454969432846 no 2087 0.380060083737792 2944 4661669 SGTC_477 mead ethanolamide 10 µM -0.305499870897539 0.382390643579536 no 2088 0.379992734140445 2910 16061185 SGTC_255 tunicamycin 200.472 nM -0.305602408685344 0.382353355278225 no 2089 0.379953693150867 3016 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_978 1416-0512 87.4 µM -0.307168223781665 0.381784075696268 no 2090 0.379357665423187 3015 6814003 SGTC_637 1181-0519 7.26 µM -0.307383786067123 0.3817057242269 no 2091 0.379275634024165 2955 6252091 YGR060W ERG25 SGTC_861 0443-0273 110 µM -0.309500048138909 0.380936773989078 no 2092 0.37847058777545 3037 6149169 SGTC_19 0279-0214 38.434 µM -0.309611161394463 0.380896413610564 no 2093 0.3784283337709 2958 3566274 YBR002C RER2 SGTC_2232 chlorophetanol 41.5365 µM -0.309787126537048 0.380832499317607 no 2094 0.37836142094892 3024 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3355 9151058 44.0485 µM -0.310798056624199 0.380465370999799 no 2095 0.37797707358141 2993 17015728 SGTC_2628 lathosterol 100 µM -0.312373076717171 0.37989360293291 no 2096 0.37737850452584 3126 6710616 SGTC_1507 4075-3230 155 µM -0.312387224637989 0.379888468103813 no 2097 0.377373129096424 2929 659771 SGTC_1620 st003704 16.5 µM -0.312925772360329 0.379693024004054 no 2098 0.37716852834495 3025 2834414 SGTC_1228 0124-0032 52.5 µM -0.313478278120805 0.379492546334977 no 2099 0.376958660597022 3036 X1228 SGTC_2322 7413319 38.22 µM -0.315940899627593 0.378599374549118 no 2100 0.376023683633392 3084 1840400 SGTC_1270 0831-1170 17.3 µM -0.316439511459492 0.378418611037748 no 2101 0.375834465359788 2951 6764716 SGTC_2861 9024595 19.48 µM -0.316678107017852 0.378332121554188 no 2102 0.375743931255844 2997 16482810 SGTC_340 k038-0059 454 µM -0.317216724908125 0.378136898161575 no 2103 0.375539580068619 2974 23733424 SGTC_1275 0867-0008 21.1 µM -0.31858201643122 0.377642184334718 no 2104 0.375021746110403 2936 3422836 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.318932442208406 0.37751523976857 no 2105 0.374888871314858 3168 165506 SGTC_3018 9082602 49.47 µM -0.319637860162296 0.377259736558793 no 2106 0.374621435280502 2977 17332089 SGTC_3307 9126885 69.2785 µM -0.3217080607215 0.376510218033044 no 2107 0.373836935334864 2968 24824909 SGTC_988 1497-1057 103 µM -0.323092168658761 0.3760093595173 no 2108 0.37331272049461 3034 3533044 SGTC_696 1560-0013 611 µM -0.323508687239503 0.375858677364072 no 2109 0.373155014745514 3173 1650269 SGTC_1782 st039423 80.636 µM -0.323750384165748 0.37577124837331 no 2110 0.373063511174699 3013 2068169 SGTC_428 3448-4153 16.5 µM -0.324961218687846 0.375333349482717 no 2111 0.372605211556826 2910 3834874 SGTC_174 3553-0389 74.3 µM -0.326202026200118 0.37488477744667 no 2112 0.372135754241552 3118 738071 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.326384736703249 0.374818738915106 no 2113 0.372066642078914 2906 4000243 SGTC_863 0466-0191 129 µM -0.326569899284719 0.374751817853804 no 2114 0.371996606596599 3108 765160 YPR165W RHO1 SGTC_666 0272-0154 136 µM -0.326602551756187 0.374740017059045 no 2115 0.371984256637713 3024 6870312 SGTC_1865 st057639 52.2 µM -0.328171073821319 0.374173282321668 no 2116 0.371391158779375 2939 688818 SGTC_2305 7443522 69.23 µM -0.328466322931003 0.374066633963474 no 2117 0.371279551718291 2967 5415886 SGTC_805 3852-0218 479 µM -0.329459602973631 0.373707917275211 no 2118 0.370904161616889 2962 6615355 SGTC_305 1682-2595 20.8 µM -0.331137393125206 0.373102242722242 no 2119 0.370270353892919 3051 226033 SGTC_2359 9039622 200 µM -0.331341454547925 0.373028598836258 no 2120 0.370193290934654 2955 6463596 SGTC_1104 tacrolimus 29.8 µM -0.332543754883518 0.372594794002314 no 2121 0.369739353030409 3028 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_66 0109-0187 42.4 µM -0.33286924416848 0.372477381209025 no 2122 0.369616493189866 2925 759417 SGTC_800 3448-7362 155 µM -0.335128146867539 0.371662860933037 no 2123 0.368764210594473 3071 15991913 SGTC_541 4513-1321 94 µM -0.335221246104422 0.371629303294294 no 2124 0.368729098121757 3001 747515 SGTC_3168 9103419 49.47 µM -0.336962697896784 0.371001776680403 no 2125 0.368072510038567 3076 16649256 SGTC_717 1532-0246 73.2 µM -0.339722839170311 0.370007871521863 no 2126 0.367032630232202 3062 9561992 SGTC_2221 6807166 181.081 µM -0.33984200248037 0.369964981240371 no 2127 0.3669877574993 3062 674925 SGTC_301 4119-0100 24.5 µM -0.341642859682209 0.369316998443746 no 2128 0.366309839253701 3017 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1215 3852-0577 11.2 µM -0.34206187458583 0.369166282034184 no 2129 0.36615216417863 3170 2884876 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.345420498433476 0.367958939518811 no 2130 0.364889134462135 2982 23665772 A membrane-active detergent. SGTC_282 k297-0036 65.7 µM -0.345941870548687 0.36777163564995 no 2131 0.364693200488037 3139 5061378 SGTC_1630 st005209 31.3 µM -0.346206380099378 0.367676622137882 no 2132 0.364593810123449 3094 3367314 SGTC_2378 9074213 121.43 µM -0.346329736828653 0.367632314385084 no 2133 0.364547461523852 3031 657714 SGTC_2251 lansoprazole 556 µM -0.347169555779145 0.367330711780752 no 2134 0.364231970536349 2982 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_851 0394-0702 453 µM -0.347730759915012 0.367129213191986 no 2135 0.364021196768697 3159 762646 SGTC_2136 5328288 199.296 µM -0.34924782296188 0.36658469974811 no 2136 0.363451633126221 3034 262395 SGTC_631 k072-0230 41.5 µM -0.349300648337951 0.366565744174381 no 2137 0.363431805883173 3119 5773147 SGTC_2719 novobiocin 32.65 µM -0.351290433552697 0.365851977751467 no 2138 0.362685235558298 3143 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3089 9117425 49.47 µM -0.352293045848986 0.365492501049221 no 2139 0.362309251447046 3085 9401657 SGTC_2650 prasterone 100 µM -0.35555821452879 0.364322627330757 no 2140 0.361085720586447 3089 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2478 5763493 32.33 µM -0.357612529702964 0.363587235458528 no 2141 0.360316650140655 3023 1365576 YLR208W SEC13 SGTC_2450 5739737 12.93 µM -0.357962713087139 0.363461928873899 no 2142 0.360185608853406 3126 2262825 SGTC_3315 9136395 68.55 µM -0.358218640589591 0.363370359234521 no 2143 0.360089849222314 3243 16876844 SGTC_1263 0774-1208 64.8 µM -0.359067814301762 0.363066584883954 no 2144 0.359772179341896 3213 906585 SGTC_3156 9099931 49.47 µM -0.360506147463089 0.362552247485031 no 2145 0.359234330126979 2995 18111053 SGTC_2431 5490079 200 µM -0.360567502921326 0.362530312730375 no 2146 0.359211393106925 3087 5722345 SGTC_2361 9034121 116 µM -0.361191045629643 0.362307420005209 no 2147 0.358978317757848 3061 6496917 SGTC_601 0986-0029 62.9 µM -0.361952631788319 0.362035245334729 no 2148 0.358693714065947 3059 24747981 SGTC_2001 4023502 57.655 µM -0.3632610630071 0.361567802811858 no 2149 0.358204938363715 3150 108941 YCR052W RSC6 SGTC_1454 4239-0054 42.6 µM -0.363636700729119 0.361433642791502 no 2150 0.35806465855096 3218 1340767 SGTC_1497 4476-2978 41.3 µM -0.363721423336707 0.361403386238803 no 2151 0.358033022013032 3123 1528379 SGTC_2262 9014885 67.46 µM -0.364311144495262 0.361192806153551 no 2152 0.357812839382819 3021 6457424 SGTC_1681 tripelennamine 100 µM -0.364860663497698 0.360996619471685 no 2153 0.357607709496612 3133 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_578 3460-0051 92 µM -0.365910360157816 0.360621963389769 no 2154 0.357215982700869 3176 2876744 SGTC_2374 9071832 200 µM -0.366941447674478 0.360254079457929 no 2155 0.356831346935484 3061 17381698 SGTC_1140 3229-1848 2.98 µM -0.367782875825086 0.359953960335019 no 2156 0.356517569293095 3155 2849525 SGTC_1810 st050138 53 µM -0.372448798764668 0.358291298022203 no 2157 0.354779363416984 3187 3444541 SGTC_2337 9009472 200 µM -0.374028676176195 0.357728928542254 no 2158 0.354191490771528 3263 5742383 SGTC_1198 1612-1005 86.7 µM -0.375723063292047 0.357126141521589 no 2159 0.353561395031594 3238 6998509 SGTC_1424 4048-1941 275 µM -0.376143188266049 0.35697673496631 no 2160 0.353405224146168 3205 X1424 SGTC_1899 st063254 59.6 µM -0.376846824151258 0.35672655424193 no 2161 0.353143720502249 3020 3093813 SGTC_1885 st057546 99.9 µM -0.377023566850145 0.356663722304139 no 2162 0.353078045629943 3242 702008 SGTC_2076 5212012 200 µM -0.378478231711786 0.356146737573426 no 2163 0.352537680899836 3080 604802 SGTC_1915 st067105 30.6 µM -0.379547033955 0.355767055975519 no 2164 0.35214084214475 3107 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_487 nimodipine 119 µM -0.379877384680961 0.355649731014464 no 2165 0.352018217787293 3116 4497 L-type voltage-gated calcium channels inhibitor SGTC_736 0958-0254 92.6 µM -0.380122834328895 0.355562567756455 no 2166 0.351927118202261 3178 6812352 SGTC_1600 coumarin 106 71.1 µM -0.381535915273806 0.355060906212438 no 2167 0.351402813212671 3231 100336 A hepatotoxic, DNA x-linker. SGTC_804 1595-0054 20.9 µM -0.381576580419863 0.355046473286616 no 2168 0.351387729127212 3071 761523 Stimulates phospholipase C. SGTC_1765 st044815 90.4 µM -0.381761955099149 0.354980682502892 no 2169 0.351318970320843 3156 645695 SGTC_2257 7960413 200 µM -0.382440943787065 0.354739741554944 no 2170 0.3510671627573 3051 2974689 YIL048W NEO1 SGTC_897 1000-0139 31.4 µM -0.382969595677206 0.354552188240804 no 2171 0.350871153878599 3225 6151020 SGTC_1227 3909-8010 46.6 µM -0.383233388372986 0.354458613951709 no 2172 0.350773361989589 3080 15982272 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.385477044049137 0.353663085171927 no 2173 0.349942005547183 3102 2724278 An inhibitor of dopamine biosynthesis. SGTC_2823 7987624 58.44 µM -0.386199096973759 0.353407203893919 no 2174 0.349674611238914 3305 2239440 SGTC_630 4356-0227 183 µM -0.386272753244728 0.353381105289504 no 2175 0.349647338662878 3146 779312 SGTC_913 3487-1245 167 µM -0.387955662225731 0.352784988697298 no 2176 0.34902442260392 3027 4016153 SGTC_728 3030-5151 22.5 µM -0.389869352811569 0.35210756409651 no 2177 0.348316578576915 3078 3125388 SGTC_1412 3909-8563 178 µM -0.392049680698174 0.351336324622652 no 2178 0.347510753108768 3211 23767530 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.394135697683205 0.350599017900274 no 2179 0.346740428373334 3110 2346 DNA damaging agent; causes G2/M arrest. SGTC_2676 harmalol 100 µM -0.394286489739509 0.350545741922976 no 2180 0.346684768356978 3183 5459187 A monoamine oxidase inhibitor SGTC_2807 7945238 51.95 µM -0.395244276632642 0.350207417220186 no 2181 0.346331309573106 3166 17148797 SGTC_46 0329-0187a 2.197 µM -0.395691837517814 0.350049363378263 no 2182 0.346166188901052 3181 46494817 SGTC_3148 9097893 49.47 µM -0.396284532014386 0.349840096318345 no 2183 0.345947568430199 3071 17174100 SGTC_1289 0976-0073 69.1 µM -0.396824804852879 0.349649377895681 no 2184 0.345748328869674 3203 3391136 SGTC_2585 alliin 100 µM -0.396920985318353 0.349615429792458 no 2185 0.345712864316536 3297 87310 A garlic compound which reacts with lipids. SGTC_1316 1272-0050 65.9 µM -0.397092530493949 0.349554883753662 no 2186 0.345649613949576 3110 7340392 SGTC_2845 9003024 42.97 µM -0.397360394960336 0.349460349941537 no 2187 0.345550858344436 3312 2990173 SGTC_1756 st041558 35.5 µM -0.398133867757649 0.349187430985051 no 2188 0.345265755333557 3284 3955792 SGTC_1876 myriocin 605 nM -0.399290943680093 0.348779303724752 no 2189 0.34483941967207 3275 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_3285 9112818 20.8695 µM -0.399451475651847 0.348722694217497 no 2190 0.344780285680767 3103 17017947 YPR165W RHO1 SGTC_599 1935-0052 86.5 µM -0.399970948221548 0.348539532075303 no 2191 0.344588957354366 3094 9557311 SGTC_715 0868-0130 184 µM -0.400142705904628 0.348478979365466 no 2192 0.344525705566268 3259 2876258 SGTC_1755 st041960 45.185 µM -0.400987984950284 0.348181034790033 no 2193 0.34421448497787 3218 2257073 SGTC_846 0335-0850 148 µM -0.401423236545824 0.34802765351528 no 2194 0.344054272209592 3183 6819598 SGTC_739 1486-1183 203 µM -0.402038640123997 0.34781082968437 no 2195 0.343827794651801 3246 4346692 SGTC_2520 obtusaquinone 4.71 µM -0.402435745821372 0.347670944690744 no 2196 0.343681683657608 3265 5967872 SGTC_197 4544-0043 41.561 µM -0.40395590247054 0.347135644015298 no 2197 0.343122573443307 3137 896523 SGTC_2682 pyrogallin 40.03 µM -0.404219521142833 0.347042845587367 no 2198 0.343025649976917 3149 822798 An ATP competetive kinase inhibitor. SGTC_38 0929-0051 58.268 µM -0.404509773041563 0.346940682402341 no 2199 0.342918946340103 3233 1379719 SGTC_924 2046-0044 21.3 µM -0.405284078372494 0.346668195999373 no 2200 0.342634354229037 3099 3623589 SGTC_2306 7482397 179.52 µM -0.406429158740944 0.346265375248652 no 2201 0.342213649291058 3271 891448 SGTC_786 4544-0069 423 µM -0.407935847152681 0.345735611551548 no 2202 0.3416603871027 3199 748821 YLR208W SEC13 SGTC_250 brefeldin a 552.239 µM -0.413103514741758 0.343920917298178 no 2203 0.339765387212096 3114 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2596 sinensetin 100 µM -0.413685629568345 0.343716724226137 no 2204 0.339552176348967 3144 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1037 k284-1091 78.7 µM -0.413806436217994 0.343674353621748 no 2205 0.339507934997416 3147 3334711 SGTC_2027 5150920 200 µM -0.41452143291176 0.34342362253085 no 2206 0.339246136926376 3169 786715 SGTC_705 1124-0212 310 µM -0.415472689666862 0.343090147873602 no 2207 0.338897951850517 3291 9554485 SGTC_2249 haloperidol 116.36 µM -0.416115702015386 0.342864801235957 no 2208 0.338662670278782 3145 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_398 bronopol 33.3 µM -0.416934328132202 0.342577990823785 no 2209 0.338363221803364 3088 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2697 mebhydrolin 72.4 µM -0.420142622319417 0.341454822293092 no 2210 0.337190633799098 3311 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2345 9052315 157.45 µM -0.422441619332912 0.340650845030673 no 2211 0.336351352452542 3236 6469265 SGTC_1009 4106-0057 9.87 µM -0.422623900885466 0.340587130650044 no 2212 0.33628484280701 3290 2928005 SGTC_321 4534-3890 65.3 µM -0.422835484119244 0.340513179914465 no 2213 0.336207648189734 3235 699746 SGTC_1665 st014639 11.4 µM -0.42394704307139 0.340124778247783 no 2214 0.335802217426878 3221 981133 YIL048W NEO1 SGTC_1840 st055363 71 µM -0.42401943274416 0.34009948967783 no 2215 0.335775820589108 3183 676033 SGTC_2938 9059746 27.26 µM -0.427668063011855 0.338825813052638 no 2216 0.334446402403714 3247 6471769 SGTC_690 glyoxal 20.3 µM -0.429213904961572 0.338286739360744 no 2217 0.333883782350469 3220 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1158 4092-0494 91.8 µM -0.430004948941486 0.338011010644648 no 2218 0.333596020600047 3289 1148199 SGTC_1112 tnp00069 1.16933 µM -0.430469980459166 0.337848958372723 no 2219 0.333426899588273 3247 145826 SGTC_490 phenamil 164 µM -0.431063458413655 0.337642189265234 no 2220 0.333211114804405 3206 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2446 5162541 200 µM -0.431758823460141 0.337399984798834 no 2221 0.332958354754701 3122 1549321 SGTC_2602 kawain 100 µM -0.431789364764555 0.337389348418553 no 2222 0.332947254955224 3229 5369129 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.43281718342657 0.337031473898018 no 2223 0.332573794395611 3113 6708514 SGTC_1468 k284-1086 134 µM -0.434356823774261 0.336495664959459 no 2224 0.332014672969712 3210 15996457 SGTC_157 1348-1695 65.819 µM -0.435915082526488 0.335953714494953 no 2225 0.331449170858846 3248 5380510 SGTC_1717 st033143 58.0435 µM -0.436270642248851 0.335830101271665 no 2226 0.331320189717734 3326 674616 SGTC_1135 dihydrocapsaicin 536.708 nM -0.4364440230096 0.335769830483329 no 2227 0.331257302199227 3124 107982 A Capsaicinoid. SGTC_2111 5486399 200 µM -0.436474792385994 0.335759134844127 no 2228 0.331246142232429 3196 689674 SGTC_2372 9071633 200 µM -0.436836803335154 0.335633307430927 no 2229 0.331114853130424 3303 21321366 SGTC_119 0121-0043 24.815 µM -0.436888606082066 0.335615303389476 no 2230 0.331096067727419 3263 1092378 SGTC_339 3091-4833 71.4 µM -0.437387813111399 0.335441823364177 no 2231 0.330915060411587 3194 3240077 SGTC_1540 guanosine 70.6 µM -0.439629270008078 0.334663324831539 no 2232 0.330102818870003 3232 6802 Guanosine is a purine nucleoside SGTC_3078 9116413 49.47 µM -0.440331625968564 0.334419529877115 no 2233 0.329848469092972 3124 17177322 SGTC_2769 toremifene 3.73 µM -0.441854711594859 0.333891091201586 no 2234 0.329297172265687 3355 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_139 0099-0334 718.624 µM -0.442282265100158 0.333742809494651 no 2235 0.329142481413132 3208 97690 SGTC_2190 6049624 200 µM -0.44801389071244 0.331757514078873 no 2236 0.327071585843498 3248 2265554 SGTC_2064 5220758 200 µM -0.44873478818215 0.331508145496279 no 2237 0.326811493015812 3351 788518 SGTC_1103 duloxetine 36.1 µM -0.44922493269911 0.331338640242891 no 2238 0.326634701655596 3327 60835 A selective serotonin reuptake inhibitor. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.44979694917824 0.331140865132117 no 2239 0.326428428928002 3235 165521 SGTC_2742 clothiapine 36.27 µM -0.450961620809079 0.33073832469803 no 2240 0.3260086051127 3249 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.452127955291307 0.330335405610625 no 2241 0.325588402812434 3191 4330530 SGTC_3107 9121808 49.47 µM -0.453074770677592 0.330008465627961 no 2242 0.32524745085893 3288 662681 SGTC_570 0987-0065 62.6 µM -0.453401176630466 0.329895786128236 no 2243 0.325129944671193 3204 3104428 SGTC_1122 capsaicin 818.572 nM -0.453866336015135 0.329735233843657 no 2244 0.324962517279177 3312 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_923 1900-2434 73.3 µM -0.454322296788868 0.329577886953212 no 2245 0.324798435096019 3200 5910570 SGTC_917 harmaline 728.087 nM -0.454590097222392 0.329485486120794 no 2246 0.324702080191279 3264 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2085 5307070 144.047 µM -0.454720252932067 0.329440581453871 no 2247 0.32465525425223 3161 2840351 SGTC_522 1273-0010 11.6 µM -0.455084861369171 0.329314801987385 no 2248 0.324524094338158 3384 5705015 SGTC_2022 5136654 200 µM -0.455568822855891 0.329147878971228 no 2249 0.324350033388522 3299 1713771 SGTC_3111 9122088 49.47 µM -0.455719268223759 0.329095995840506 no 2250 0.324295932222862 3191 16876704 SGTC_2812 7970281 58.44 µM -0.45658732577659 0.328796698710263 no 2251 0.323983845363543 3338 2233435 SGTC_1680 diphenhydramine 100 µM -0.45687982642762 0.3286958722716 no 2252 0.323878712430687 3201 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1429 4049-0205 9.46 µM -0.457416943956195 0.328510757644639 no 2253 0.32368569392548 3276 22774478 SGTC_787 4152-0075 138 µM -0.457712945506078 0.328408760308074 no 2254 0.323579343098782 3223 9566539 SGTC_2757 clomiphene 4.22 µM -0.459197273671783 0.327897477843906 no 2255 0.323046254100836 3407 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2993 9054257 71.4286 µM -0.461147464031927 0.327226217515666 no 2256 0.322346405305718 3200 6470217 YGL055W OLE1 SGTC_1843 st055809 45.5 µM -0.461637118738147 0.327057764777608 no 2257 0.322170785669736 3300 16413835 SGTC_2593 nobiletin 86.24 µM -0.461827448976671 0.326992296204086 no 2258 0.322102532506856 3251 72344 An anti-infammatory. SGTC_588 3970-1144 52.9 µM -0.462306564322423 0.326827516757395 no 2259 0.321930746445429 3287 1888707 SGTC_782 0083-0095 30.5 µM -0.463009565738062 0.326585798560484 no 2260 0.32167875525871 3217 3591729 An indicator and reagent. SGTC_1210 3013-0140 750 nM -0.464059696803734 0.326224859786326 no 2261 0.321302488064718 3312 905973 SGTC_1706 st031321 9.9705 µM -0.464556989791799 0.326053992799683 no 2262 0.321124369449588 3319 6103185 SGTC_954 1189-0853 2.85 µM -0.466546168148273 0.325370888107277 no 2263 0.320412304486471 3293 2828194 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.467194845116159 0.325148252292645 no 2264 0.320180240700673 3361 688798 SGTC_968 1309-0633 340 µM -0.467527191311946 0.325034210189538 no 2265 0.320061371291747 3317 3761976 SGTC_1248 0469-0687 58.6 µM -0.468223579029777 0.32479530313399 no 2266 0.319812355993314 3297 4017482 SGTC_2804 7954240 19.48 µM -0.470585504115544 0.323985543647945 no 2267 0.31896838067239 3329 828705 SGTC_1957 st077035 62.4 µM -0.471584620349553 0.32364325810255 no 2268 0.318611653242398 3337 705593 SGTC_3176 9106582 49.47 µM -0.471890769401637 0.323538404852777 no 2269 0.318502378496101 3258 17018027 SGTC_3132 9126706 49.47 µM -0.472449351892219 0.323347131562664 no 2270 0.318303042568196 3380 850858 SGTC_2143 5623677 140.463 µM -0.474219751863185 0.322741208826818 no 2271 0.317671604832918 3309 5375313 SGTC_2475 5812728 15.03 µM -0.475355891231026 0.322352610627704 no 2272 0.317266664001121 3226 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_886 0866-0150 153 µM -0.475380225600506 0.322344289569132 no 2273 0.317257993177315 3379 271463 SGTC_2179 6298986 200 µM -0.475567654496398 0.322280201850675 no 2274 0.317191211865149 3338 738374 SGTC_188 3229-0966 278.469 µM -0.475667635481882 0.322246017429416 no 2275 0.317155590862815 3364 5722370 SGTC_1014 4130-3005 69.3 µM -0.476301108745884 0.322029462025021 no 2276 0.316929937802623 3205 743608 SGTC_2474 5321570 43.32 µM -0.477419192183303 0.321647388122242 no 2277 0.316531825191853 3303 2841384 SGTC_2725 haloperidol 53.21 µM -0.479073853838597 0.321082299625449 no 2278 0.315943044756157 3228 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2260 7964312 200 µM -0.47953268102734 0.320925677443309 no 2279 0.315779862242022 3366 231951 SGTC_1975 st070967 30.8 µM -0.480272882108876 0.320673074517127 no 2280 0.315516684404901 3392 261391 SGTC_1880 MG-132 525 µM -0.481178204846316 0.320364234618517 no 2281 0.315194924891878 3354 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.481486059434484 0.320259242076664 no 2282 0.315085542633127 3353 229346 A bile salt which induces apoptosis. SGTC_622 1348-1566 26.3 µM -0.482405352558187 0.319945806592619 no 2283 0.314759009756123 3308 7340407 SGTC_159 3970-0959 50 µM -0.482535219770142 0.319901538367458 no 2284 0.314712892594064 3411 6615653 SGTC_2563 tomatine 8.54 µM -0.484067874524716 0.3193792916342 no 2285 0.314168849835791 3432 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2748 diazoxide 86.69 µM -0.485217030355718 0.318987955654546 no 2286 0.313761201384843 3284 3019 A potassium channel activatior. SGTC_1106 tegaserod maleate 11.7 µM -0.486277347278908 0.318627051939715 no 2287 0.313385268965351 3286 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1730 st033808 45.1 µM -0.486862556731314 0.318427935820846 no 2288 0.313177867550367 3208 1045166 SGTC_1995 st072814 61.1 µM -0.489648252564706 0.317480829155402 no 2289 0.312191412734429 3266 5769371 SGTC_1550 gossypolone 36.6 µM -0.491464778578639 0.316863872281045 no 2290 0.311548878764167 3309 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_556 4058-0063 51.5 µM -0.491517684543126 0.316845911151897 no 2291 0.311530173673142 3313 6615692 SGTC_1661 st013063 9.66 µM -0.492750373167799 0.316427546025451 no 2292 0.311094490024198 3287 721395 SGTC_1137 ixabepilone 100 µM -0.492774037862013 0.316419516704092 no 2293 0.31108612851938 3361 154225 A novel microtubule stabilizer. SGTC_1552 6-methylflavone 10.6 µM -0.493179569843707 0.316281935027301 no 2294 0.310942856058646 3356 689013 SGTC_1064 honokiol 6.76 µM -0.493989788719881 0.316007134546656 no 2295 0.310656695525813 3331 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_29 0299-0004 12.984 µM -0.495673500606829 0.315436398184223 no 2296 0.310062393119726 3291 16871 A napthoquinone isolated from Swertia calycina. SGTC_409 arachidonic acid 100 µM -0.496821667314139 0.315047450549314 no 2297 0.30965740716984 3274 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2282 7944268 200 µM -0.498327025494971 0.31453781297649 no 2298 0.309126781179502 3441 2970414 SGTC_2706 st078239 82.5 µM -0.500592109698755 0.313771636589714 no 2299 0.308329108298536 3378 15434492 SGTC_222 nsc-310342 10.666 µM -0.500848604766671 0.313684926330064 no 2300 0.308238837821604 3356 432556 SGTC_393 acivicin 6.25 µM -0.501515019099215 0.31345968761892 no 2301 0.308004355207074 3229 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1891 st059073 26.2 µM -0.501766030244581 0.313374867393146 no 2302 0.307916055463919 3400 688754 SGTC_1508 1080-0625 72.9 µM -0.509239333765618 0.31085406964542 no 2303 0.305292237767009 3356 767111 SGTC_1063 disulfiram 1.84 µM -0.509318816178329 0.310827307038429 no 2304 0.305264385491973 3344 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2797 7859098 81.82 µM -0.510132273922888 0.310553464374158 no 2305 0.304979397979538 3289 972681 SGTC_1328 1441-0025 69.2 µM -0.510213456259093 0.310526140884795 no 2306 0.304950962973885 3334 4562601 SGTC_3216 9129716 49.47 µM -0.512535684987846 0.309744992886261 no 2307 0.304138076072174 3290 8056934 SGTC_2687 chenodiol 100 µM -0.513516073615784 0.309415468633349 no 2308 0.303795185037665 3396 5702181 A cholesterol synthesis inhibitor. SGTC_2180 6301957 200 µM -0.516626966225108 0.308370863261859 no 2309 0.302708293814032 3384 845462 SGTC_878 0828-0289 13.7 µM -0.517909282737191 0.307940725245006 no 2310 0.30226078252843 3340 745350 YLR208W SEC13 SGTC_2999 9069765 71.4286 µM -0.518945260191968 0.307593411339975 no 2311 0.301899457222516 3331 2097066 SGTC_850 0388-0143 75.9 µM -0.519302533284897 0.30747367464777 no 2312 0.301774893537873 3311 67273 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.519669076033081 0.307350852635537 no 2313 0.301647121992743 3361 6312947 SGTC_985 1493-0307 8.71 µM -0.519990821496011 0.307243059205901 no 2314 0.301534986194518 3439 3278274 SGTC_3153 9100258 49.47 µM -0.523511924934962 0.306064484234227 no 2315 0.300309027359162 3297 25236848 SGTC_2054 5233173 129 µM -0.523828601869681 0.30595858500198 no 2316 0.300198878985079 3405 6889 SGTC_3236 9132701 49.47 µM -0.524105666404696 0.305865945766254 no 2317 0.300102523806297 3375 24282524 SGTC_1716 st033144 30.6155 µM -0.524491912751087 0.305736821250213 no 2318 0.299968221641718 3463 674617 SGTC_1076 itraconazole 331 nM -0.525298779992727 0.305467158526517 no 2319 0.29968775268964 3401 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_389 tpck 16.7 µM -0.526448080391821 0.30508323357109 no 2320 0.299288458412269 3377 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_532 1548-0774 215 µM -0.526485722648283 0.305070662761517 no 2321 0.299275384680234 3520 5932993 SGTC_332 4112-0506 40.9 µM -0.52678086022138 0.304972108145234 no 2322 0.299172887862719 3361 2790355 SGTC_3039 9090270 49.47 µM -0.52702922065047 0.304889184673336 no 2323 0.299086648386095 3448 17173750 SGTC_363 0455-0021 3.06 µM -0.530060829761591 0.303877788794295 no 2324 0.298034878019977 3399 4597466 SGTC_2786 7743617 45.45 µM -0.530202934425438 0.303830417018985 no 2325 0.297985618363676 3309 583674 SGTC_2858 9025781 8.96 µM -0.530836490281272 0.303619255985717 no 2326 0.297766045520228 3439 4894980 YPL153C RAD53 SGTC_969 1313-0238 134 µM -0.530952315909672 0.303580658961654 no 2327 0.297725911558992 3317 5212874 SGTC_2298 7976326 193.81 µM -0.53228062037052 0.303138179634966 no 2328 0.297265826241128 3344 2235818 SGTC_1113 artemisinin 1.17947 µM -0.533358758944009 0.302779246763419 no 2329 0.296892630031947 3424 2240 An anti-malaria and mitochondrial poison. SGTC_149 3970-0822 46.1 µM -0.535542415149848 0.30205284983405 no 2330 0.296137418020697 3458 3114250 YBL034C STU1 SGTC_1649 st011737 51.3 µM -0.535588069920817 0.302037671052243 no 2331 0.296121637843955 3383 1761035 SGTC_2166 5933061 31.504 µM -0.535588324112583 0.302037586542399 no 2332 0.29612154998585 3680 2877375 SGTC_2862 9027634 71.43 µM -0.536522595861088 0.301727045740009 no 2333 0.295798711853303 3304 5012562 SGTC_1608 st001473 40.5 µM -0.537805489724781 0.301300861160954 no 2334 0.295355670794329 3316 7292267 SGTC_685 1278-0033 54.9 µM -0.537952279765165 0.301252113969121 no 2335 0.295304997051278 3463 3590572 SGTC_1644 st010134 20.9 µM -0.538649467762244 0.301020634809132 no 2336 0.295064373752581 3426 3818134 SGTC_1348 1493-0373 93.8 µM -0.540146273772249 0.300523938910437 no 2337 0.294548080378003 3375 3010129 SGTC_85 0868-0259 160.055 µM -0.54075815025198 0.300321002168912 no 2338 0.294337145892365 3363 83173 SGTC_1166 k206-0078 225 µM -0.541102939251101 0.3002066757307 no 2339 0.294218316216884 3412 5404595 SGTC_2607 solasodine 47.35 µM -0.541854045915308 0.299957689097559 no 2340 0.293959528100749 3357 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1930 st074634 34.3 µM -0.546750979176612 0.298336685740851 no 2341 0.292274912689438 3363 684253 YOR116C RPO31 SGTC_1521 st012942 49.4 µM -0.546751644062607 0.298336465918486 no 2342 0.292274684264294 3453 24207259 SGTC_468 gf-109203x 121 µM -0.546868131739666 0.29829795429372 no 2343 0.292234665580867 3368 2396 A protein kinase C inhibitor. SGTC_1751 st044839 27.194 µM -0.546868371443328 0.298297875048379 no 2344 0.292234583234656 3450 5291326 SGTC_3101 9120531 49.47 µM -0.547873210761385 0.297965762334253 no 2345 0.29188948228876 3514 24824904 SGTC_1380 2291-0730 164 µM -0.548283155107709 0.297830318718474 no 2346 0.291748745974993 3372 2999191 SGTC_767 0929-0023 86 µM -0.549767117524475 0.297340259711817 no 2347 0.291239557516574 3482 1204563 SGTC_1817 st052116 64.4 µM -0.55055752356188 0.29707938900195 no 2348 0.290968516830156 3455 4361398 SGTC_1990 st072050 59.8 µM -0.551068466024854 0.296910809969425 no 2349 0.290793370645074 3342 17233948 SGTC_86 0417-1630 471.922 µM -0.551615634349655 0.296730327221746 no 2350 0.290605861257985 3449 3634867 SGTC_257 daunorubicin 18.5 µM -0.55169560310082 0.296703953842747 no 2351 0.29057846146512 3443 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_440 fluspirilene 35.1 µM -0.552294638608118 0.296506428437198 no 2352 0.290373251633678 3533 3396 An atypical antipsychotic. SGTC_512 prima-1 270 µM -0.552769069762929 0.296350032726397 no 2353 0.290210775316145 3487 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3329 9141233 27.5565 µM -0.552781102867887 0.296346066518371 no 2354 0.290206654946345 3479 4909101 YNL103W MET4 SGTC_111 0083-0039 52.457 µM -0.552922298353235 0.296299529170887 no 2355 0.290158308906338 3394 759313 SGTC_14 0354-0009 295 µM -0.553066816436418 0.296251900182047 no 2356 0.290108829100731 3431 1713507 SGTC_421 streptovitacin 30 mM -0.55424826029423 0.295862662149198 no 2357 0.289704477147795 3475 91467 include heat shock SGTC_1784 st039334 36.3 µM -0.556974761562521 0.294965287824738 no 2358 0.288772336552461 3534 3496984 SGTC_1799 st045822 46.1415 µM -0.55841388638245 0.294492134387373 no 2359 0.288280896299439 3460 3674992 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.561813743998729 0.293375727606746 no 2360 0.287121463468776 3449 91467 include heat shock SGTC_2098 5376439 882.5 nM -0.562569905124979 0.293127694799144 no 2361 0.286863894864207 3457 2844116 SGTC_2252 omeprazole 400 µM -0.566305930063299 0.291903649146012 no 2362 0.285592914955547 3390 4594 A proton pump inhibitor. SGTC_2970 9090938 41.86 µM -0.568402764660276 0.29121770123452 no 2363 0.28488075679909 3506 17217104 SGTC_2371 9071574 200 µM -0.569812412146103 0.290756979677129 no 2364 0.284402468049242 3465 45596039 SGTC_1441 4106-0040 13 µM -0.570522664590131 0.290524973809707 no 2365 0.284161627184404 3467 2904180 SGTC_453 enantio-paf c16 10 µM -0.574310402608791 0.289289164414084 no 2366 0.282878885493851 3488 13871343 A lipid and platelet activating factor SGTC_758 0868-0029 16 µM -0.57441860596054 0.289253897685414 no 2367 0.282842282628785 3494 762687 SGTC_297 0986-0032 24 µM -0.57507757326165 0.289039164051459 no 2368 0.282619417299219 3411 2847425 SGTC_997 3996-0078 137 µM -0.575368388699267 0.288944421661889 no 2369 0.282521089227679 3428 735687 SGTC_1558 st069300 45.6 µM -0.579501409592377 0.287599540665466 no 2370 0.281125447887481 3470 24208000 SGTC_1196 1588-0294 184 µM -0.580401625141267 0.287307004301053 no 2371 0.280821904730945 3458 6144269 SGTC_2167 5876490 200 µM -0.580857330017136 0.287158970965878 no 2372 0.280668306306385 3520 686534 SGTC_3027 9089541 49.47 µM -0.581968326003687 0.286798221158365 no 2373 0.280294007969501 3508 9943819 SGTC_1504 k297-0033 30 µM -0.582724464206408 0.286552819593246 no 2374 0.280039400771784 3326 4388117 SGTC_1267 0828-0272 9.49 µM -0.582734328040867 0.286549618984349 no 2375 0.280036080157884 3551 745334 SGTC_2436 5633522 8.09 µM -0.583912161497394 0.286167558522967 no 2376 0.279639705289514 3526 5724242 SGTC_1641 st009299 47.1 µM -0.585164418508497 0.285761622449571 no 2377 0.279218583647197 3459 4046054 SGTC_207 4185-0010 4.486 µM -0.58565568163449 0.285602447686373 no 2378 0.279053460939713 3548 3761753 SGTC_1331 1472-0049 76.2 µM -0.587278673384668 0.285076880338949 no 2379 0.278508280945868 3428 24051409 SGTC_362 0310-0100 9.03 µM -0.587520890814853 0.284998483532776 no 2380 0.278426962082792 3507 790235 SGTC_2978 9011784 42.97 µM -0.587882987601455 0.28488130539736 no 2381 0.278305418096915 3474 2994934 SGTC_3251 9135047 49.47 µM -0.588233524129354 0.284767890176214 no 2382 0.278187779154353 3478 17682963 SGTC_497 capsazepine 133 µM -0.59000738826505 0.2841942915182 no 2383 0.277592848114897 3431 2733484 A calcium channel blocker. SGTC_3128 9127691 49.47 µM -0.590959491127689 0.283886646493763 no 2384 0.277273781733318 3482 41316314 SGTC_1926 methyl fluorone black 53.6 µM -0.591157126377274 0.283822806254548 no 2385 0.277207573179817 3390 72721 Reacts with homocysteine. SGTC_2477 5967686 25.23 µM -0.591916274205591 0.283577649859828 no 2386 0.276953327728815 3472 776118 SGTC_2608 thymoquinone 42.66 µM -0.591979840506573 0.283557126597804 no 2387 0.276932043982736 3477 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1760 st045453 10.4495 µM -0.59211447884898 0.283513659091676 no 2388 0.276886966006963 3513 3323419 YIL048W NEO1 SGTC_1225 1216-0074 20.6 µM -0.593195715411996 0.283164701585383 no 2389 0.27652508985414 3451 4241466 SGTC_79 0052-0007 94.094 µM -0.593745144884075 0.282987458113157 no 2390 0.276341291675711 3564 2801472 SGTC_248 streptozotocin 5.23457 mM -0.594270623204179 0.282817991018803 no 2391 0.276165561854304 3534 5300 DNA alkylating agent. SGTC_473 2-arachidonoylglycerol 10 µM -0.594724797935233 0.282671558662803 no 2392 0.276013721496477 3408 5282280 An endocannabinoid. SGTC_1627 st003713 25.6 µM -0.595053050827622 0.282565747976387 no 2393 0.275904005039681 3501 16195070 YER133W GLC7 SGTC_2834 9001755 58.44 µM -0.595740317504183 0.282344272670282 no 2394 0.27567435990133 3374 2989575 SGTC_2684 capsaicin 100 µM -0.59622595015698 0.282187825362385 no 2395 0.275512145975778 3522 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2827 7993847 71.43 µM -0.596422771054306 0.28212443109145 no 2396 0.275446416053567 3478 2985692 SGTC_1481 3346-2004 36 µM -0.597147662684291 0.281891009053421 no 2397 0.275204399210554 3517 2770522 SGTC_1205 4161-2785 76 µM -0.597417148752771 0.281804255694396 no 2398 0.275114453612291 3472 3498106 SGTC_2551 apiole 73.87 µM -0.599738592419285 0.281057466402037 no 2399 0.274340232017879 3421 10659 A possible DNA adduct former. SGTC_2289 7946404 165.07 µM -0.600846030042477 0.280701550011504 no 2400 0.273971271299983 3518 1246120 YPR165W RHO1 SGTC_84 0443-0269 128.823 µM -0.602241838867553 0.280253265564171 no 2401 0.273506584703821 3495 6150058 SGTC_336 4111-0029 111 µM -0.602422533531746 0.280195258188908 no 2402 0.273446457155978 3477 3131175 SGTC_64 000l-0018 272.079 µM -0.602424266099302 0.280194702020805 no 2403 0.273445880662392 3503 6811119 SGTC_2389 9091542 195.52 µM -0.603362607832993 0.279893565400647 no 2404 0.273133745783179 3466 3626624 YOL127W RPL25 SGTC_109 0132-0036 33.701 µM -0.604094135916848 0.279658909227688 no 2405 0.272890529016174 3442 67274 A color developer. SGTC_1115 galangin 695.678 nM -0.604186722334162 0.279629216596244 no 2406 0.272859753757199 3577 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.6049144737632 0.279395878697495 no 2407 0.272617912805367 3502 6708739 YPR165W RHO1 SGTC_2665 lovastatin 100 µM -0.604995221841585 0.279369994387249 no 2408 0.272591085762327 3529 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2058 5236698 133 µM -0.605461873877356 0.279220428932316 no 2409 0.272436075001687 3482 766665 SGTC_2801 7907800 81.82 µM -0.605633301757109 0.279165494795386 no 2410 0.27237914171477 3508 6620925 SGTC_1279 0874-0590 65.2 µM -0.606232528951384 0.278973513476601 no 2411 0.272180177511824 3485 3523074 SGTC_992 3909-8734 162 µM -0.609114698828118 0.278051017839741 no 2412 0.271224207679084 3491 4288319 SGTC_687 k029-0044 34.9 µM -0.609511085751982 0.277924262851619 no 2413 0.271092863502898 3547 5829338 SGTC_2571 chrysanthemic acid 100 µM -0.611162660560267 0.277396432781475 no 2414 0.27054595014922 3463 2743 An insecticide. SGTC_2739 tacrine 100.86 µM -0.611330321917588 0.277342876969697 no 2415 0.270490460497694 3532 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_355 1311-2252 105 µM -0.612378981341489 0.277008020043353 no 2416 0.270143522435446 3479 5338538 SGTC_2921 7974240 10.71 µM -0.612440642533424 0.276988336612694 no 2417 0.270123129402284 3535 2979074 YDR527W RBA50 SGTC_2925 9010536 32.5 µM -0.613705705577671 0.276584655510907 no 2418 0.269704908693729 3532 2994177 SGTC_2491 paeonol 100 µM -0.614758639343351 0.276248884822531 no 2419 0.269357063871652 3509 11092 Increases levels of cortical cytochrome oxidase. SGTC_1515 3460-0031 42.1 µM -0.615778514491547 0.275923847031028 no 2420 0.269020354815014 3510 2876596 SGTC_379 3970-0972 5.9 µM -0.616650653149738 0.275646042470452 no 2421 0.26873258823558 3516 2898042 YBL034C STU1 SGTC_1398 3558-0053 112 µM -0.61794729620116 0.27523327380468 no 2422 0.268305040327888 3456 4532369 SGTC_1583 clindamycin 39.6 µM -0.618014254722854 0.275211966735868 no 2423 0.268282971089831 3482 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2045 5106652 78.05 µM -0.618249381559604 0.27513715276438 no 2424 0.268205481539528 3528 673349 SGTC_1452 4194-0072 190 µM -0.618995265573551 0.274899889515953 no 2425 0.267959738908309 3583 1343545 SGTC_2890 9046729 58.44 µM -0.620736112005344 0.274346524592806 no 2426 0.267386632512251 3444 903329 SGTC_1292 0kpi-0043 232 µM -0.62131474184371 0.274162716681025 no 2427 0.267196278011162 3504 3333905 SGTC_44 0929-0055 61.211 µM -0.621783393207273 0.274013889199094 no 2428 0.267042153780434 3469 1379590 SGTC_2964 9083345 53.42 µM -0.62387620459577 0.273349772242779 no 2429 0.266354444302097 3491 17741579 SGTC_797 k781-0471 270 µM -0.625582627634279 0.272808859435866 no 2430 0.265794368217729 3511 23738129 SGTC_2040 5100729 123 µM -0.625786264152606 0.272744344919994 no 2431 0.265727571256794 3529 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1056 3448-1962 115 µM -0.626046595054791 0.272661879962404 no 2432 0.265642189769645 3534 715507 SGTC_2287 7945887 168.79 µM -0.626206743463514 0.272611155937637 no 2433 0.265589672340249 3557 1245853 SGTC_2174 5790901 200 µM -0.626361580047095 0.272562118788389 no 2434 0.265538901823769 3547 786020 SGTC_2932 9016711 44.54 µM -0.626698399508507 0.272455462313903 no 2435 0.265428476596693 3559 7117328 SGTC_2326 6164455 177.58 µM -0.626701006286219 0.272454636938513 no 2436 0.265427622063495 3519 2888790 SGTC_2561 acetosyringone 100 µM -0.627411485008357 0.272229726714991 no 2437 0.265194770616011 3514 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2843 9000894 45.46 µM -0.628448050095312 0.271901755690162 no 2438 0.264855234178564 3435 2242070 SGTC_2087 5276107 200 µM -0.629132879675378 0.271685182284882 no 2439 0.264631033228165 3558 144405 SGTC_3297 9117502 71.43 µM -0.630396822211991 0.271285693383386 no 2440 0.264217494712751 3553 7453720 SGTC_1472 k841-0093 193 µM -0.630473893955385 0.271261343121835 no 2441 0.264192288920565 3625 X1472 SGTC_2707 st078556 66.6 µM -0.631482166417254 0.270942887098456 no 2442 0.26386265308531 3522 17250899 SGTC_1636 st007707 68.9 µM -0.63162973272723 0.270896294932892 no 2443 0.263814426634553 3613 403051 SGTC_2110 5483698 200 µM -0.63262258485607 0.270582918621351 no 2444 0.263490067467785 3554 2848765 YHR062C RPP1 SGTC_3063 1327-0034 4 µM -0.633350380595181 0.27035331777532 no 2445 0.263252430077745 3521 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3202 9113761 49.47 µM -0.634113584036622 0.27011265136443 no 2446 0.263003349121547 3568 4798415 SGTC_2101 5377231 179.231 µM -0.635161359650896 0.269782423426116 no 2447 0.262661590804284 3564 2844213 SGTC_858 0438-0351 2.77 µM -0.636796418807463 0.269267505268751 no 2448 0.262128729543936 3571 2799119 SGTC_1560 lithocholic acid 53.1 µM -0.638800130403357 0.268637162750777 no 2449 0.26147648172139 3533 9903 A bile acid which acts as a detergent. SGTC_672 1441-0018 53.7 µM -0.638891300857472 0.268608499317311 no 2450 0.26144682376542 3552 251141 SGTC_2708 st078559 56 µM -0.639262010433926 0.268491966325556 no 2451 0.261326248891443 3526 17250902 SGTC_439 amiodarone 34.4 µM -0.63940130090252 0.268448186772931 no 2452 0.261280951455092 3512 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1557 sumaresinolic acid 42.3 µM -0.639924052605558 0.268283915836197 no 2453 0.261110987924824 3537 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_50 0929-0078 56.389 µM -0.642495233304968 0.267476677665089 no 2454 0.260275841649125 3485 1377751 SGTC_2658 polymyxin b sulfate 77.05 µM -0.642581703176778 0.2674495512156 no 2455 0.260247779275125 3554 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1257 0669-0121 16 µM -0.642903370741186 0.267348653118392 no 2456 0.260143401049861 3616 4307855 SGTC_8 0354-0001 70 µM -0.642972451396943 0.267326986958478 no 2457 0.260120987814832 3616 4993152 SGTC_1252 0493-0875 34.8 µM -0.644086431357341 0.266977725441693 no 2458 0.259759694260784 3582 3960963 SGTC_2481 5478948 45.16 µM -0.644678700209411 0.266792127728863 no 2459 0.259567711095666 3599 77792 SGTC_3061 glucosamine 200 µM -0.645739582540133 0.266459844932699 no 2460 0.259224010729334 3543 91431 and experimental redox chemotherapeutic SGTC_877 0771-0151 33.1 µM -0.646766411496354 0.266138427614892 no 2461 0.258891566996179 3567 6166523 SGTC_485 niflumic acid 177 µM -0.650064586073696 0.265107364904251 no 2462 0.257825251727101 3610 4488 A COX2 inhibitor. SGTC_1656 st012921 11 µM -0.650851783133334 0.26486157463147 no 2463 0.257571084573033 3553 6732821 SGTC_501 nsc-95397 161 µM -0.651568554199033 0.264637874596079 no 2464 0.257339769529195 3616 262093 SGTC_2081 5214970 32.255 µM -0.651682483394709 0.264602326817445 no 2465 0.257303012454238 3574 2063512 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.651891658170084 0.264537067179442 no 2466 0.257235533320435 3608 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_699 0375-0592 111 µM -0.652715389342817 0.264280154089276 no 2467 0.256969889673618 3632 762578 SGTC_1632 st005650 90 µM -0.652784502165417 0.264258604305084 no 2468 0.256947608089783 3582 2759605 SGTC_2675 theaflavin digallate 100 µM -0.653722992719127 0.263966066035545 no 2469 0.256645143561974 3594 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_179 1273-0063 6.77 µM -0.65505644822565 0.263550696711764 no 2470 0.256215705531343 3568 3108139 SGTC_1856 st057054 55.7 µM -0.655528921671522 0.263403602033591 no 2471 0.256063635863615 3674 1266018 SGTC_1286 0929-0070 131 µM -0.655712632076888 0.26334641897843 no 2472 0.256004519793682 3658 1420408 SGTC_933 2914-0560 114 µM -0.655900674934049 0.263287893937818 no 2473 0.255944016961127 3630 463887 SGTC_590 k048-0076 22.4 µM -0.656572762537058 0.263078772771064 no 2474 0.255727833623232 3610 6832814 SGTC_103 0844-0104 51.839 µM -0.656651797107226 0.263054186612901 no 2475 0.255702417672019 3643 5375804 SGTC_2651 TUB2.036 5 µM -0.659218740482289 0.262256298054138 no 2476 0.254877657186204 3711 15992207 YFL037W TUB2 SGTC_77 0828-0286 12.516 µM -0.65923122282412 0.262252421171978 no 2477 0.25487365000653 3587 745345 SGTC_293 4049-0273 38.5 µM -0.659269143488772 0.262240643598309 no 2478 0.254861476618384 3540 1380311 SGTC_2911 7942208 15.64 µM -0.659441448190849 0.262187131827934 no 2479 0.254806166758195 3588 1243384 SGTC_1849 st056239 19.2 µM -0.659443311248129 0.262186553258551 no 2480 0.254805568750598 3535 5393181 SGTC_3214 9129694 49.47 µM -0.659521975466613 0.26216212481148 no 2481 0.254780319633641 3574 17158655 SGTC_2671 danthron 100 µM -0.660135283211481 0.261971707752347 no 2482 0.254583509123449 3580 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3260 9137109 49.47 µM -0.660310981526433 0.261917170791066 no 2483 0.254527142196861 3503 17478346 SGTC_2331 7980721 200 µM -0.662963955936741 0.261094392675533 no 2484 0.253676819483319 3598 2981221 SGTC_1415 3966-0071 78.1 µM -0.663634802427388 0.260886550882558 no 2485 0.253462038514987 3610 2893185 SGTC_813 k007-0158 173 µM -0.663707917185993 0.260863903597421 no 2486 0.253438635569915 3624 6523916 SGTC_3334 9142812 21.919 µM -0.664123831715681 0.260735093377164 no 2487 0.253305529131066 3621 45283678 SGTC_651 3253-0966 34.4 µM -0.664584598740571 0.260592430401691 no 2488 0.253158111328978 3628 781462 SGTC_2396 5342950 42.78 µM -0.664686930370115 0.260560751872418 no 2489 0.253125377471925 3616 1886677 SGTC_1766 st045414 44.774 µM -0.665611447897095 0.260274641346242 no 2490 0.2528297436105 3659 253960 SGTC_1793 st048256 72.231 µM -0.666392687499591 0.260032997307292 no 2491 0.252580067637869 3558 672022 SGTC_395 anisomycin 6.25 µM -0.667237701254784 0.25977175767392 no 2492 0.252310156414092 3582 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_354 2783-3500 4.88 µM -0.667780021387219 0.259604168454519 no 2493 0.252137010634311 3591 6740761 SGTC_3219 9131112 49.47 µM -0.6698976027658 0.258950322700034 no 2494 0.251461534016272 3568 17612988 YMR079W SEC14 SGTC_2309 7664088 163.95 µM -0.670670127618052 0.258712002388012 no 2495 0.251215348495155 3642 704922 SGTC_1724 st037281 8.293 µM -0.671934500032393 0.258322194510551 no 2496 0.250812697892549 3641 574124 YDL195W SEC31 SGTC_405 ebelactone b 50 µM -0.673795326437808 0.257749053086136 no 2497 0.250220723271493 3627 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2083 5306046 65.942 µM -0.674314807622893 0.257589168895109 no 2498 0.250055595931052 3658 539837 SGTC_2874 9043904 71.43 µM -0.674353594660812 0.257577233216303 no 2499 0.250043269026002 3584 4463428 SGTC_2383 9036125 200 µM -0.674490759476595 0.257535026698093 no 2500 0.249999679274407 3587 79580 SGTC_390 dec-rvkr-cmk 16.7 µM -0.675240493783336 0.257304392001647 no 2501 0.249761491689971 3679 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_520 3584-0023 682 µM -0.679590934227872 0.255968222997762 no 2502 0.248381755786056 3618 1340790 SGTC_1611 st001856 99.4 µM -0.679753818464822 0.255918266082927 no 2503 0.24833017630485 3610 647478 SGTC_1419 3993-2473 62.6 µM -0.680027625761643 0.255834300314194 no 2504 0.248243484415515 3680 704026 SGTC_1699 st031318 29.054 µM -0.680963723118945 0.255547345269844 no 2505 0.24794722254793 3679 5340658 SGTC_7 0192-1582 4.227 µM -0.681296999367636 0.255445222030734 no 2506 0.247841790789771 3683 252616 SGTC_3183 9108214 49.47 µM -0.681721635351118 0.255315135042877 no 2507 0.24770749210901 3556 4974831 SGTC_65 0798-0905 34.986 µM -0.682754701852175 0.254998800380207 no 2508 0.247380928801499 3758 3602145 SGTC_3015 9080845 49.47 µM -0.683090219609835 0.254896105824893 no 2509 0.247274917595599 3687 5296973 SGTC_1312 1218-2183 165 µM -0.684027648414231 0.254609294388524 no 2510 0.246978853534915 3663 6744073 SGTC_2997 9067075 71.4286 µM -0.684436622024382 0.254484219670419 no 2511 0.246849748630454 3655 27209819 SGTC_2640 pentamidine 10.38 µM -0.68473654570449 0.254392515710086 no 2512 0.246755091603907 3667 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2634 4'-methoxyflavone 100 µM -0.684872052947242 0.254351089014574 no 2513 0.246712331389809 3639 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1938 st074717 56.4 µM -0.688780867948307 0.253157626618454 no 2514 0.245480588566033 3568 17250979 SGTC_1101 ebselen 5.29 µM -0.689013791936137 0.253086601994402 no 2515 0.245407294190935 3724 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_518 1021-0119 62.6 µM -0.689067442197817 0.253070244109939 no 2516 0.245390413687259 3621 1097762 SGTC_458 nppb 133 µM -0.690119790143262 0.252749497283861 no 2517 0.245059429417753 3690 4549 A chloride channel blocker. SGTC_2199 6590217 200 µM -0.690788830153952 0.252545690859626 no 2518 0.244849128016692 3612 703109 SGTC_261 5-fluorouridine 15.376 µM -0.691107213049929 0.252448733831687 no 2519 0.24474908386413 3682 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2028 5153890 36.43 µM -0.692474031936795 0.2520327199494 no 2520 0.24431984410926 3645 2830968 YPR165W RHO1 SGTC_1437 4092-1038 11.6 µM -0.693186163880616 0.25181611425105 no 2521 0.244096365010434 3662 3977136 SGTC_2241 6772625 37.8075 µM -0.693235293007613 0.251801174509077 no 2522 0.244080951522184 3603 2285411 SGTC_1781 st038725 66.3 µM -0.693513026659268 0.251716726912237 no 2523 0.243993826844534 3686 4270275 YIL048W NEO1 SGTC_2863 9028737 58.44 µM -0.695438567225055 0.25113165926348 no 2524 0.243390248957406 3660 6460917 SGTC_1044 1222-0021 1.78 µM -0.695843441146972 0.251008731561872 no 2525 0.243263440343254 3657 4306703 SGTC_328 k915-0120 63.5 µM -0.696485670716224 0.250813803336877 no 2526 0.243062363982986 3646 6624543 SGTC_446 go6976 132 µM -0.696609283100847 0.250776293954293 no 2527 0.243023672364039 3638 3501 A protein kinase C inhibitor. SGTC_879 0831-1030 162 µM -0.69691847208287 0.250682485554931 no 2528 0.242926908444144 3698 1549252 SGTC_2752 diclazuril 33.15 µM -0.698023824477824 0.250347272029074 no 2529 0.24258114740025 3716 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3001 9076041 71.4286 µM -0.698602714622501 0.250171810379392 no 2530 0.242400173382044 3682 16004211 SGTC_789 1309-1135 70.6 µM -0.699021456121798 0.250044930462561 no 2531 0.242269311022482 3684 3092424 SGTC_3264 9137442 49.47 µM -0.699051071142674 0.250035958316243 no 2532 0.242260057379476 3705 17015726 SGTC_41 0478-0632 82.643 µM -0.699424070689736 0.249922969256097 no 2533 0.242143524660998 3662 3750424 SGTC_2131 toluylene red 5.2905 µM -0.699634370036399 0.249859277305451 no 2534 0.242077836226379 3675 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2581 avocatin a 64 µM -0.700484143644062 0.249601999857864 no 2535 0.241812502085685 3688 6710728 A skin care supplement. SGTC_2555 cholic acid 100 µM -0.702388785146365 0.249025862201202 no 2536 0.241218368660713 3703 6708657 Influences liver metabolism. SGTC_2037 5169046 200 µM -0.70315851433368 0.248793226668511 no 2537 0.240978484821926 3703 5718022 SGTC_2974 9094440 9.66 µM -0.703408975467221 0.248717554666689 no 2538 0.240900457331535 3749 25236134 SGTC_3106 9121286 49.47 µM -0.704405662304021 0.248416546432123 no 2539 0.240590090382434 3696 15943471 SGTC_3275 9138069 49.47 µM -0.705299015862387 0.248146910856481 no 2540 0.240312086392839 3735 17617007 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.707796954348437 0.247393802196097 no 2541 0.239535678999321 3743 5393153 SGTC_2193 5925765 200 µM -0.708524283735683 0.247174748008612 no 2542 0.239309868719496 3677 877370 SGTC_1554 st069299 38.7 µM -0.708786779544985 0.247095716040611 no 2543 0.239228401538544 3668 24207999 SGTC_1266 0828-0227 32.9 µM -0.70958699030977 0.246854872843266 no 2544 0.238980144766022 3687 3913820 SGTC_110 0850-0284 111.64 µM -0.709925618744699 0.246752992101056 no 2545 0.238875131372159 3549 3906265 SGTC_1160 4092-0570 10.5 µM -0.71078845960228 0.246493497073704 no 2546 0.238607666521604 3687 4994975 SGTC_1390 3413-2614 145 µM -0.711194113387156 0.246371549297313 no 2547 0.238481977948187 3734 3421432 SGTC_1217 1183-1422 255 µM -0.71264632225849 0.245935250999618 no 2548 0.23803231996294 3744 2849664 SGTC_2407 paclitaxel 400 µM -0.71333551785361 0.245728335826729 no 2549 0.237819082041506 3846 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1870 st057514 26.5 µM -0.713344759950087 0.245725561734469 no 2550 0.237816223238119 3696 5393161 SGTC_1174 0739-0097 51.1 µM -0.714081267442489 0.2455045469474 no 2551 0.237588464311182 3708 728447 SGTC_3283 9109332 35.8195 µM -0.717789665730975 0.244393337100399 no 2552 0.236443493153882 3604 17027281 SGTC_2669 eugenol 100 µM -0.718126658092227 0.244292492914316 no 2553 0.236339597219569 3671 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1591 genipin 88.4 µM -0.719875393469367 0.243769548272514 no 2554 0.2358008597775 3706 442424 A DNA cross-linking agent. SGTC_2766 oltipraz 83.91 µM -0.720005803804421 0.243730574382119 no 2555 0.235760711074478 3685 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1487 3970-0795 2.82 µM -0.720161808436682 0.243683955905805 no 2556 0.235712687749824 3765 3765103 SGTC_122 0236-0016 402.397 µM -0.720843613762037 0.24348027022604 no 2557 0.235502869107516 3767 6808838 SGTC_733 4069-0007 56.1 µM -0.725259608041887 0.242163245465225 no 2558 0.234146390236776 3745 5717425 YNL287W SEC21 SGTC_3029 9088683 49.47 µM -0.725356849546238 0.242134287712954 no 2559 0.234116568931713 3712 25236615 SGTC_692 k241-0027 77.8 µM -0.725414200200714 0.242117210021024 no 2560 0.234098982043397 3745 3600480 SGTC_1077 5-fluorocytosine 377 nM -0.725771297096269 0.242010889559906 no 2561 0.233989492811355 3732 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_942 3253-1115 227 µM -0.72634500070948 0.241840130598902 no 2562 0.233813649354037 3749 46497897 SGTC_2223 6903751 107.57 µM -0.727002054768762 0.241644643287344 no 2563 0.233612348505593 3675 5598863 SGTC_2710 st078562 53.7235 µM -0.727204706070785 0.241584367604863 no 2564 0.233550281869653 3700 17250908 SGTC_18 0111-0177 500 nM -0.729654577127227 0.240856335392666 no 2565 0.232800676308172 3802 721752 SGTC_294 k038-0071 157 µM -0.731599794874165 0.240279123025427 no 2566 0.232206436739228 3729 24152826 SGTC_227 fluconazole 33.516 µM -0.731923529971039 0.240183133004911 no 2567 0.232107621732952 3716 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1913 st060213 96.1 µM -0.733474572360486 0.239723526723049 no 2568 0.231634515496912 3737 688959 SGTC_1311 1190-0148 100 µM -0.73925049376331 0.238016229332955 no 2569 0.229877452375254 3809 1961333 SGTC_967 1306-0166 352 µM -0.739739691613069 0.237871934745163 no 2570 0.229728979545839 3705 4437607 SGTC_2132 5317594 122.667 µM -0.739861999322392 0.237835866162875 no 2571 0.229691867229255 3717 794577 SGTC_1633 st005664 67.9 µM -0.740500490357496 0.237647623660512 no 2572 0.22949818187515 3768 2063822 SGTC_1581 himbacine 57.9 µM -0.740971609193381 0.237508778935028 no 2573 0.229355327339032 3743 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1117 retinoic acid 1.10837 µM -0.74118623466984 0.237445540837145 no 2574 0.229290264274647 3748 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2525 harmine 47.85 µM -0.742836454450112 0.236959622459016 no 2575 0.228790350938216 3741 5280953 A monoamine oxidase inhibitor SGTC_2740 felodipine 17.08 µM -0.742902635598352 0.236940146378901 no 2576 0.228770314960589 3658 3333 L-type calcium channel blocker SGTC_2572 astragaloside iv 100 µM -0.747399191243889 0.235618943132604 no 2577 0.227411316718247 3774 45006101 An anti-inflammatory agent. SGTC_951 1171-0579 82.7 µM -0.748353701579387 0.235339007339789 no 2578 0.227123420422291 3732 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_585 0kpi-0023 191 µM -0.748409890722397 0.23532253408823 no 2579 0.227106479241964 3688 64601 SGTC_517 1365-0151 113 µM -0.751038628949944 0.23455256568579 no 2580 0.226314704166008 3823 768657 SGTC_795 0685-0265 78 µM -0.751987007349601 0.234275124136462 no 2581 0.226029436114193 3801 302754 SGTC_3052 9092717 49.47 µM -0.752244774750129 0.234199747472837 no 2582 0.225951935959007 3729 25237534 SGTC_1307 1187-1599 12.2 µM -0.752335103301811 0.23417333666283 no 2583 0.225924781399013 3767 1538471 SGTC_2718 lomofungin 53.02 µM -0.753043185305604 0.233966360490872 no 2584 0.225711981795278 3757 5351222 A RNA synthesis inhibitor. SGTC_2118 5526350 200 µM -0.75659613082812 0.232929346976257 no 2585 0.224645930049574 3808 743594 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.758933791416767 0.232248438849022 no 2586 0.223946081844579 3593 88881 An O-methylated flavonoid and antioxidant. SGTC_2039 Aminomethylbenzodioxan 200 µM -0.759401723848347 0.232112273784213 no 2587 0.223806141317 3750 15053 SGTC_326 k292-0812 17.5 µM -0.759698387565312 0.232025969739586 no 2588 0.223717446402597 3721 3579357 SGTC_2255 7941087 197.44 µM -0.761099495643346 0.231618607358938 no 2589 0.22329882085301 3773 935561 SGTC_1330 1469-0054 61.8 µM -0.761934931762088 0.231375899969856 no 2590 0.223049420086266 3807 7102664 SGTC_2324 6149169 200 µM -0.762460484954263 0.231223291171774 no 2591 0.2228926092529 3720 2888231 SGTC_2711 st079103 59.1 µM -0.763778567323919 0.23084079691118 no 2592 0.222499605586915 3755 54693780 SGTC_1423 4048-0112 5.59 µM -0.764217597920116 0.230713473134421 no 2593 0.22236879059701 3793 X1423 SGTC_1615 st002656 86.5 µM -0.765229065796475 0.230420285512203 no 2594 0.222067577354849 3778 1584458 SGTC_1727 st034309 9.9045 µM -0.767069362126397 0.229887385392617 no 2595 0.221520138384391 3870 870305 SGTC_1882 5615643 20 µM -0.767297841210797 0.229821272199948 no 2596 0.221452225837771 3707 2253075 SGTC_404 fumagillin 50 µM -0.76865756789363 0.229428039072217 no 2597 0.221048310398273 3773 12015870 A methionine aminopeptidase binder. SGTC_2328 6201408 200 µM -0.768753064909413 0.229400435502688 no 2598 0.221019958257672 3797 2890418 SGTC_1839 st053978 48 µM -0.769017563114313 0.229323991579999 no 2599 0.220941442164129 3808 3788398 SGTC_3201 9113999 49.47 µM -0.769096209291988 0.229301264417399 no 2600 0.220918099185244 3823 16649224 SGTC_531 3788-1495 174 µM -0.769605023317589 0.229154257920037 no 2601 0.220767112167989 3751 2896655 SGTC_2619 obliquin 87.91 µM -0.770566162071797 0.228876710089302 no 2602 0.220482062247406 3762 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1519 esterone 74 µM -0.770956301244381 0.228764103541596 no 2603 0.220366416854153 3792 698 A steroid. SGTC_659 k018-0002 107 µM -0.773069393429179 0.228154738806784 no 2604 0.219740656724927 3763 6797879 YHR007C ERG11 SGTC_1801 st050089 28.441 µM -0.775060926322467 0.227581265205723 no 2605 0.219151829453081 3815 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_284 0988-0104 32.6 µM -0.776787254098017 0.227084816382141 no 2606 0.218642148942879 3796 4666532 SGTC_808 0711-0032 135 µM -0.777137740764784 0.226984099769447 no 2607 0.21853875475311 3751 4252555 SGTC_657 3534-0529 86.7 µM -0.777140029409607 0.226983442182274 no 2608 0.218538079691349 3808 1049549 SGTC_2986 9022445 71.43 µM -0.781077504864152 0.225853695121905 no 2609 0.217378455768885 3720 6459286 SGTC_450 aminopyrene 156 nM -0.781125643664034 0.225839902761594 no 2610 0.217364300454417 3733 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_663 1486-0733 13.9 µM -0.782163949248677 0.225542531358719 no 2611 0.217059114104508 3825 722445 YPR165W RHO1 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.782216837306471 0.225527390117966 no 2612 0.217043575490941 3858 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1642 st009582 77.7 µM -0.784502339836165 0.22487362695702 no 2613 0.2163727047615 3768 6739311 SGTC_1991 st073000 8.92 µM -0.784662634880093 0.224827815252224 no 2614 0.216325697938175 3869 4301969 YIL048W NEO1 SGTC_2192 5915882 198.485 µM -0.785909339089523 0.224471692670836 no 2615 0.215960301419269 3776 2876149 SGTC_467 ro 31-8220 72.8 µM -0.788546848750392 0.223719340750771 no 2616 0.215188453325209 3748 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_834 0312-0008 75.7 µM -0.789798694850216 0.223362752868721 no 2617 0.214822670702135 3797 6385573 YIL048W NEO1 SGTC_2943 9068529 45.32 µM -0.79549598601696 0.221743973038997 no 2618 0.213162522479878 3830 3270634 SGTC_523 1934-0222 13.7 µM -0.797193234303509 0.221263030260359 no 2619 0.212669407378841 3819 1361595 SGTC_1603 st002045 67.8 µM -0.79759009276985 0.221150660115576 no 2620 0.212554201078061 3824 5887985 SGTC_2586 curcumin 80 µM -0.797774294084139 0.221098514763017 no 2621 0.212500740619713 3848 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2463 5473429 200 µM -0.797906351058816 0.221061135226025 no 2622 0.212462418765782 3829 5399405 SGTC_1709 st033179 39.1045 µM -0.798066036937889 0.221015939988966 no 2623 0.212416084623056 3798 573381 SGTC_773 4358-1457 44.6 µM -0.798721624645148 0.220830447130744 no 2624 0.212225922459202 3805 1186886 SGTC_1370 2001-0092 44.6 µM -0.801244445974327 0.220117468790828 no 2625 0.21149507258205 3886 790957 SGTC_1397 3532-0190 20.1 µM -0.80151579342485 0.220040861601427 no 2626 0.211416552334468 3744 5322280 SGTC_2273 7815444 169.05 µM -0.802128259656137 0.219868005519304 no 2627 0.211239384767919 3757 2824616 SGTC_2275 7947463 200 µM -0.802455022034151 0.219775815403658 no 2628 0.21114489809845 3772 1225414 SGTC_1414 3917-0015 5.4 µM -0.803193879897487 0.219567441809263 no 2629 0.210931341162693 3798 6618702 SGTC_1792 st045773 43.6 µM -0.803488878721107 0.219484277588748 no 2630 0.210846111106124 3750 2919270 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.803857343340918 0.219380427771839 no 2631 0.210739683933538 3860 6710655 SGTC_1295 1013-0063 9.78 µM -0.80538382887206 0.2189504967455 no 2632 0.210299110285882 3823 6826038 SGTC_1884 5633444 25 µM -0.805927675478939 0.21879744081075 no 2633 0.210142276257611 3867 5724239 SGTC_1480 1070-0044 41.2 µM -0.806216081556312 0.218716299048381 no 2634 0.210059133840447 3844 3124987 SGTC_691 1548-0686 185 µM -0.807854902968771 0.218255552894999 no 2635 0.209587057412349 3859 46495133 SGTC_72 0744-0168 198.391 µM -0.808968119358939 0.217942897093819 no 2636 0.209266742178642 3758 677577 SGTC_2113 5491891 107.031 µM -0.81017620091751 0.217603890035038 no 2637 0.208919456821737 3865 789979 SGTC_1895 st058434 18.3 µM -0.812118175357636 0.217059579117332 no 2638 0.208361912489557 3862 5393175 SGTC_1982 st072467 71.9 µM -0.815654382822781 0.216070448127697 no 2639 0.207348918118466 3832 3163533 SGTC_1604 st002052 72.4 µM -0.816075178191554 0.215952919337393 no 2640 0.207228569768976 3890 6254834 YHR062C RPP1 SGTC_2513 baicalein 25.65 µM -0.81694913579277 0.215708940026526 no 2641 0.206978748117741 3869 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2175 5807670 165.306 µM -0.817773028190477 0.215479083617612 no 2642 0.206743400928637 3839 241186 SGTC_2749 bexarotene 57.39 µM -0.819189414230584 0.215084260603032 no 2643 0.206339176779476 3897 82146 An retinoic acid receptor inhibitor. SGTC_2564 betulinic acid 100 µM -0.819317334897218 0.215048622920741 no 2644 0.206302692418566 3872 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1422 4031-0024 15.5 µM -0.823567423892246 0.213866532513737 no 2645 0.205092696056067 3807 782427 SGTC_3318 9139014 38.6185 µM -0.823962591470753 0.213756815910205 no 2646 0.204980406933667 3846 16643984 SGTC_745 0469-0705 296 µM -0.824149907882923 0.213704819757021 no 2647 0.204927192676853 3936 3486736 SGTC_1936 st074407 74.3 µM -0.824364936805936 0.213645140121316 no 2648 0.204866115768559 3908 809813 SGTC_34 0469-0683 81.75 µM -0.824606997344508 0.213577969685546 no 2649 0.204797373741118 3849 3690923 SGTC_2156 5649887 115 µM -0.825126791376446 0.213433771359962 no 2650 0.20464980539866 3909 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2692 st077426 47.7 µM -0.828342785289895 0.212542871000803 no 2651 0.203738199413422 3871 25238571 SGTC_3188 9110789 49.47 µM -0.830393336023503 0.211975959586343 no 2652 0.203158216056201 3858 849217 SGTC_1040 k898-0338 155 µM -0.831872801360653 0.211567484747964 no 2653 0.202740372793553 3843 20969351 SGTC_3253 9135987 49.47 µM -0.832275268027079 0.211456444991165 no 2654 0.202626793621803 3844 4182430 SGTC_946 3434-1334 87.4 µM -0.833348941203415 0.211160387701491 no 2655 0.202323980948332 3871 4047976 SGTC_1211 1056-0033 32.3 µM -0.833828352478503 0.211028272137744 no 2656 0.202188857973471 3870 6741922 SGTC_1754 st042065 16.137 µM -0.835131612797018 0.21066936627045 no 2657 0.201821804564596 3773 1126236 YIL048W NEO1 SGTC_505 gw-5074 63.9 µM -0.835719347737528 0.210507626728056 no 2658 0.201656404088551 3927 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1553 gossypol 38.6 µM -0.835929957343382 0.210449686538322 no 2659 0.201597154060595 3752 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1686 st019653 115.5 µM -0.836178193212675 0.210381407118161 no 2660 0.201527332165936 3828 97252 SGTC_616 4092-0450 108 µM -0.838894704334195 0.209635057574993 no 2661 0.200764199886702 3915 787165 SGTC_2859 9028643 45.46 µM -0.83933423979331 0.209514443657938 no 2662 0.200640887198469 3807 17151580 SGTC_2887 9044784 58.44 µM -0.842054823588154 0.208768790974797 no 2663 0.199878633456266 3871 6465546 SGTC_288 1315-0019 35.1 µM -0.842264508679293 0.208711385847811 no 2664 0.199819956219994 3956 6811474 SGTC_330 1488-0319 80.1 µM -0.84297951926832 0.2085157085881 no 2665 0.199619949116415 3931 6846614 SGTC_1003 4049-0218 100 µM -0.845850555450003 0.207731080834532 no 2666 0.198818059251345 3927 295161 SGTC_1788 fluconazole 20 µM -0.846324475545831 0.207601730750903 no 2667 0.198685878785353 3945 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_177 1327-0068 8.361 µM -0.846539047604857 0.207543181863611 no 2668 0.198626050190335 3898 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_735 3076-0345 636 µM -0.847070701234091 0.207398155032982 no 2669 0.198477857347131 3957 2888990 SGTC_738 1315-0003 72.4 µM -0.849134302845063 0.206835804497818 no 2670 0.197903282379903 3918 6251474 SGTC_1845 st056753 3.01 µM -0.854362970533024 0.205414991023824 no 2671 0.196451953238985 3866 5375839 SGTC_2439 5492030 7.2 µM -0.855277313711096 0.205167128496335 no 2672 0.196198821847194 3899 5722370 SGTC_3042 9091578 49.47 µM -0.857223369901768 0.204640178545658 no 2673 0.195660724633705 3850 25236497 SGTC_2977 9011197 71.43 µM -0.857420086319018 0.204586956839601 no 2674 0.195606381168065 4014 2704722 SGTC_80 0159-0065 512.242 µM -0.857677287537281 0.204517383371336 no 2675 0.195535342431064 3806 1548079 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.863950047144834 0.202824951650576 no 2676 0.193807666101008 3999 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2352 9027995 87.8 µM -0.865546629961617 0.202395522674268 no 2677 0.193369416996586 3881 2997347 SGTC_2307 7538926 6.34 µM -0.866319096286226 0.202187949606521 no 2678 0.193157598446166 3951 96582 SGTC_2041 5107442 45.335 µM -0.867212188244948 0.201948121471754 no 2679 0.192912879676555 3946 793005 SGTC_1790 st045711 43.5 µM -0.867782557792777 0.201795045351817 no 2680 0.192756690163437 3901 585119 SGTC_2899 9053889 58.44 µM -0.867948795947121 0.201750443336388 no 2681 0.192711182193462 3873 6470052 SGTC_1087 pterostilbene 9.05 µM -0.868123233453327 0.201703647767451 no 2682 0.19266343669679 3989 5281727 Similar to reservatol, lowers cholesterol. SGTC_2433 5607874 27.82 µM -0.868682150166852 0.201553753473474 no 2683 0.192510503635741 3915 2252428 SGTC_368 fentichlor 4.58 µM -0.8713082066292 0.200850372731538 no 2684 0.191792945372379 3985 7329 A pesticide. SGTC_1001 4048-4355 44.4 µM -0.872488859609102 0.200534619234993 no 2685 0.191470871523355 3914 21824233 SGTC_2705 st078069 42.8 µM -0.873113466351244 0.20036769521886 no 2686 0.191300617297363 3984 1530061 SGTC_2888 9058547 12.99 µM -0.874016639541044 0.200126472938837 no 2687 0.191054596066456 3848 16476514 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.874113276045896 0.200100673304789 no 2688 0.191028284115148 3926 390807 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.874563019066714 0.199980628987841 no 2689 0.190905858426642 3979 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2466 5983409 37.09 µM -0.874591941995237 0.199972910432049 no 2690 0.190897986890468 3953 2879657 SGTC_2674 ligustilide 100 µM -0.876657905987477 0.199422037683069 no 2691 0.190336238445793 3989 5319022 A signalling regulator. SGTC_491 tetrandrine 80.3 µM -0.876812496839483 0.199380854041247 no 2692 0.190294245102099 3946 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2856 9022925 19.48 µM -0.876959858870656 0.199341600954672 no 2693 0.190254220707296 3997 4944862 SGTC_2616 abietic acid 100 µM -0.87732917599602 0.199243245740999 no 2694 0.190153934727096 3950 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2052 5265182 7.135 µM -0.878046982373967 0.199052165744232 no 2695 0.189959111397899 3954 1239884 SGTC_1916 st067606 49.2 µM -0.879212808192911 0.198742058401912 no 2696 0.189642950523645 3925 19590279 SGTC_2847 9005661 71.43 µM -0.882542627492035 0.197857938628633 no 2697 0.188741719256144 3920 2991449 SGTC_513 4245-1575 41.7 µM -0.882776195373161 0.197796011965214 no 2698 0.188678602240527 3864 719745 SGTC_876 0720-0963 56.8 µM -0.883008949432676 0.197734312724469 no 2699 0.188615718088517 3995 765861 SGTC_2524 avocatin b 10.57 µM -0.883189054967531 0.197686577717108 no 2700 0.188567067080583 3904 6710748 SGTC_977 1348-1378 135 µM -0.883986349870214 0.19747534706987 no 2701 0.188351790747438 3945 X977 SGTC_646 4092-0839 27.3 µM -0.88446675612569 0.197348136961244 no 2702 0.188222150241916 4001 877796 SGTC_818 4072-2707 53.5 µM -0.884860994657424 0.197243780837142 no 2703 0.188115803754159 3868 882871 SGTC_896 0964-0007 44.5 µM -0.886165732976319 0.19689865081877 no 2704 0.18776411299285 3888 6756758 SGTC_3021 9087658 49.47 µM -0.886517008226946 0.196805793822789 no 2705 0.187669496570474 3897 25237042 SGTC_1698 5-fluorocytosine 1.055 µM -0.887758598968389 0.196477801122523 no 2706 0.187335308672268 3983 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_140 0062-0056 502.533 µM -0.888547754811968 0.196269501047268 no 2707 0.187123089992743 3897 3758964 SGTC_2365 9042475 200 µM -0.889099357690818 0.196123983325728 no 2708 0.186974842048337 4040 6464479 SGTC_948 3448-0295 75.3 µM -0.889295654929026 0.196072214166598 no 2709 0.186922103039056 3938 678569 SGTC_730 1436-0052 41.2 µM -0.892057724559645 0.195344657056701 no 2710 0.186180996448294 3967 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_729 4092-0585 94.1 µM -0.893798271562536 0.194887022914621 no 2711 0.185714917074975 3971 2169061 SGTC_3083 9117465 49.47 µM -0.89526723232847 0.194501303482459 no 2712 0.185322126141477 3949 16420915 SGTC_1139 k015-0024 46.9 µM -0.895933439278774 0.19432652424838 no 2713 0.185144156703133 3975 2766652 SGTC_3141 9094609 49.47 µM -0.896926373060245 0.194066205855017 no 2714 0.184879103082671 3924 25236309 YDL196W YDL196W SGTC_712 r015-0009 80.6 µM -0.900068644212302 0.193243794664289 no 2715 0.184041860698588 4007 6813872 YLR060W FRS1 SGTC_535 2293-4129 48.2 µM -0.90132236423779 0.192916259219407 no 2716 0.183708473127656 3994 396118 YIL048W NEO1 SGTC_873 0591-4978 488 µM -0.90193527963873 0.192756258014684 no 2717 0.183545624498192 4073 3305145 SGTC_809 3998-0021 90 µM -0.905243039148401 0.191894169635789 no 2718 0.182668322705522 3928 715485 SGTC_2963 9082507 9 µM -0.906680631198048 0.191520232608766 no 2719 0.18228785441666 4032 16459611 SGTC_1350 1495-0454 146 µM -0.909205484640765 0.190864565725393 no 2720 0.181620834824214 4030 1069057 SGTC_2184 6075246 200 µM -0.909460958966475 0.190798299651764 no 2721 0.181553428426814 4012 2267320 SGTC_552 k242-0005 476 µM -0.910872168156724 0.190432508327499 no 2722 0.181181365847741 4063 4088318 SGTC_2269 7935389 174.42 µM -0.911065855736322 0.190382337327826 no 2723 0.181130337789519 3930 97605 SGTC_3195 9113082 49.47 µM -0.912551129745506 0.189997875856926 no 2724 0.180739333457301 3907 17018038 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.913182312119029 0.189834639619244 no 2725 0.180573332512032 4015 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2342 7990637 118.86 µM -0.914967154082717 0.189373511113939 no 2726 0.180104436842506 4062 2033102 YER133W GLC7 SGTC_1430 4049-0248 69.1 µM -0.917054222264668 0.188835175280838 no 2727 0.179557113786791 3992 22774488 SGTC_2435 5706476 10.6 µM -0.918250241074477 0.188527101127418 no 2728 0.179243935601735 3987 5725375 SGTC_1808 st050063 61.5 µM -0.920049615832749 0.188064196991982 no 2729 0.17877341597283 3948 4011993 SGTC_1655 st012546 55.1 µM -0.922197015814337 0.187512679587755 no 2730 0.178212909699613 3989 720985 YLR208W SEC13 SGTC_280 3448-3607 3.04 µM -0.923754118356132 0.187113394274709 no 2731 0.177807174174504 3970 626179 SGTC_716 1683-5115 658 µM -0.925085540355199 0.186772397267098 no 2732 0.177460706934787 3946 723597 SGTC_2891 9063876 19.48 µM -0.926414539758554 0.186432404587007 no 2733 0.177115295421723 3992 6472478 SGTC_1923 st058458 19.1 µM -0.926677403761179 0.186365202564634 no 2734 0.177047026506237 4051 3534982 SGTC_2641 levomentholum 100 µM -0.928257590880982 0.185961539009743 no 2735 0.176636983510349 3975 16666 SGTC_686 1319-0111 510 µM -0.929782110366348 0.185572610149665 no 2736 0.176241955347807 4028 4562600 SGTC_606 k015-0008 38.6 µM -0.930360009071848 0.185425311150378 no 2737 0.176092358502145 4082 1970475 SGTC_1495 4469-0029 237 µM -0.930560623785888 0.185374193997312 no 2738 0.176040445489228 4012 793680 SGTC_664 1222-0054 14.9 µM -0.931477038058606 0.185140800522458 no 2739 0.175803428468589 3973 6813991 SGTC_626 0214-0009 33 µM -0.934922262146191 0.184265000743801 no 2740 0.17491418164574 4083 3437874 SGTC_633 0437-0093 97.7 µM -0.93546174386139 0.184128094592244 no 2741 0.174775194935881 3958 2831118 SGTC_2915 7971052 15.16 µM -0.935766236687038 0.184050850350094 no 2742 0.174696779387985 3918 5741558 SGTC_1946 st076057 65.1 µM -0.935875425191244 0.184023156145289 no 2743 0.174668665689789 3940 953009 SGTC_1258 0671-0043 57.1 µM -0.935905580734371 0.184015508052044 no 2744 0.174660901790389 4040 4298767 SGTC_996 3970-0799 1.8 µM -0.936684586593878 0.183818004034714 no 2745 0.174460413510724 4033 6615648 YGL040C HEM2 SGTC_965 1291-5240 308 µM -0.93681794840317 0.183784205601395 no 2746 0.174426105605402 4039 2834598 SGTC_3160 9100216 49.47 µM -0.939635933867882 0.183070937268503 no 2747 0.173702168827617 3925 17191039 SGTC_1881 5652484 16 µM -0.940788991081394 0.182779582241337 no 2748 0.173406501815048 3991 2255129 SGTC_419 nsc-638432 893 µM -0.941178884753511 0.18268112925158 no 2749 0.173306597772907 3990 368090 SGTC_3262 9137218 49.47 µM -0.943351074600257 0.182133230662901 no 2750 0.172750679727832 3863 17650664 SGTC_185 k048-0037 25.491 µM -0.943858658413031 0.182005349341089 no 2751 0.172620940273856 4073 6827589 SGTC_3054 9094397 49.47 µM -0.946523487954829 0.181334890212925 no 2752 0.171940824033277 4041 2598354 SGTC_1643 st009866 20.2 µM -0.947239219350789 0.181155079205792 no 2753 0.171758447344465 3980 3156273 YOR207C RET1 SGTC_603 3794-0023 45.9 µM -0.948451085488743 0.180850880537082 no 2754 0.171449931575378 4057 3802260 SGTC_1059 3448-6867 171 µM -0.948774598296947 0.180769727587814 no 2755 0.1713676319126 3941 3934407 SGTC_562 3772-2733 112 µM -0.949998443558436 0.180462933487274 no 2756 0.171056521736849 4050 2876874 YIL048W NEO1 SGTC_1239 0337-0584 35.4 µM -0.950170385491847 0.180419857186071 no 2757 0.171012841834638 4109 914301 YML130C ERO1 SGTC_660 4031-1742 102 µM -0.950719766384539 0.180282265024049 no 2758 0.170873325660393 3950 6738706 SGTC_1602 st001878 87.6 µM -0.951462477895262 0.180096358024343 no 2759 0.170684828678359 4055 595405 YLR310C CDC25 SGTC_2763 lisinopril 49.32 µM -0.951775212353686 0.180018113953676 no 2760 0.170605497858025 3918 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3084 9116877 49.47 µM -0.952905080118733 0.179735606489222 no 2761 0.170319082955538 3943 27241325 SGTC_776 4476-4378 112 µM -0.959070589609187 0.178198919231907 no 2762 0.168761592667815 4103 2892008 SGTC_643 k048-0106 28.4 µM -0.959221384388023 0.178161439286466 no 2763 0.168723614905492 4052 6763920 SGTC_2568 diosmetin 100 µM -0.959245046629082 0.17815555850271 no 2764 0.168717656053408 4105 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2341 7987486 176.74 µM -0.960101956330035 0.177942672936485 no 2765 0.168501951988965 4082 1258686 SGTC_627 1391-0720 175 µM -0.960328977696813 0.177886299985049 no 2766 0.168444835163784 4018 997839 SGTC_1653 st012112 65 µM -0.960909952697004 0.177742086120835 no 2767 0.16829872303764 4042 720429 SGTC_2353 9059630 146.67 µM -0.961299214636226 0.17764550195336 no 2768 0.16820087135023 4080 4779114 SGTC_1021 4476-0760 85.3 µM -0.961610403753252 0.177568313138862 no 2769 0.168122671743999 4062 746768 SGTC_2092 5303694 80.6725 µM -0.962283625540479 0.177401396478289 no 2770 0.167953575970524 4040 1963699 SGTC_2489 cantharidin 73.42 µM -0.963637296025803 0.177066071291909 no 2771 0.167613900692464 3999 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1092 toremifene 6.32 µM -0.964375153908285 0.176883461179333 no 2772 0.167428937157158 4029 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.964844145834315 0.17676745374468 no 2773 0.167311440353435 4048 616764 SGTC_3215 9129942 49.47 µM -0.967904137948438 0.17601173089433 no 2774 0.166546123781462 4039 17682944 SGTC_2461 5755302 26.15 µM -0.967910388080201 0.176010189402661 no 2775 0.166544562913929 4108 2788904 SGTC_2014 4013930 200 µM -0.970412434350025 0.175393787757861 no 2776 0.165920476580002 3980 64556 SGTC_772 k072-0172 35.3 µM -0.970687009542063 0.175326227115883 no 2777 0.165852081339951 4104 5861980 SGTC_1271 0832-2808 169 µM -0.97110248076593 0.175224029656959 no 2778 0.16574862429328 4089 3663794 SGTC_1748 st037455 53.6035 µM -0.971342377767483 0.175165037088994 no 2779 0.165688906224506 4101 580690 SGTC_615 k087-0205 167 µM -0.97290058615064 0.174782168034397 no 2780 0.165301356818011 4054 9642773 SGTC_625 k213-0058 121 µM -0.97292341306543 0.174776563159523 no 2781 0.165295683790656 4120 3655420 SGTC_592 k241-0073 46.5 µM -0.973077772480742 0.174738665052603 no 2782 0.165257325137498 4059 4230158 SGTC_3105 9121040 49.47 µM -0.973862265036635 0.174546138179611 no 2783 0.165062466061543 3904 41448907 SGTC_905 2-aminofluorene 215 µM -0.974245830307637 0.174452054254158 no 2784 0.164967246954386 4059 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2413 inermin 26.06 µM -0.974971859466299 0.174274056288305 no 2785 0.164787109455336 4167 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2594 a-mangostin 100 µM -0.976333494844667 0.173940540323034 no 2786 0.164449613296075 4095 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_708 3448-5400 146 µM -0.977276888776391 0.173709705660341 no 2787 0.164216045773269 4007 3462195 SGTC_210 3551-0445 56.827 µM -0.977787650901795 0.173584811012928 no 2788 0.164089679986494 4106 2865180 YOR207C RET1 SGTC_1124 fisetin 1.16336 µM -0.978291075656987 0.173461766473645 no 2789 0.163965191252008 4097 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1499 4480-0877 67.3 µM -0.978439697895581 0.173425451592097 no 2790 0.163928451114339 3989 2861909 SGTC_2886 9058944 51.95 µM -0.97939309886414 0.173192609347358 no 2791 0.163692892831966 3905 4949929 SGTC_638 3970-0837 4.09 µM -0.979941754015322 0.173058705548011 no 2792 0.163557435399787 4032 4118451 YLR208W SEC13 SGTC_1179 1021-1431 9.29 µM -0.981934148360958 0.172573000100404 no 2793 0.163066145583071 4102 2840958 SGTC_2576 guaiol 23.12 µM -0.982031460918635 0.172549299552296 no 2794 0.163042174591979 3998 227829 SGTC_1997 st073024 93.8 µM -0.982391927348576 0.172461525761961 no 2795 0.162953400895782 4073 686268 SGTC_987 1497-1013 404 µM -0.984514414378766 0.171945276549709 no 2796 0.162431323837337 4034 1676435 SGTC_1920 st075728 45.7 µM -0.985696170360949 0.171658267941961 no 2797 0.162141114655874 4034 3400306 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.986906870140461 0.171364547442166 no 2798 0.161844147982303 4063 688662 SGTC_2055 5235184 200 µM -0.98699215504942 0.171343869109181 no 2799 0.161823242230684 4143 2836034 SGTC_425 3825-7017 13.1 µM -0.98733684299165 0.171260311700155 no 2800 0.161738767361414 4149 3397440 SGTC_342 k048-0088 23.3 µM -0.987544944202012 0.171209877531415 no 2801 0.16168778058785 4066 6820570 SGTC_3100 9120536 49.47 µM -0.991219396504757 0.170320923801995 no 2802 0.160789230651017 3904 16421196 SGTC_1907 st060210 83.7 µM -0.991498091197561 0.170253620534414 no 2803 0.160721211977443 4132 688793 SGTC_2325 6158266 200 µM -0.99260931242232 0.169985436032049 no 2804 0.160450192393333 4113 3623240 SGTC_1318 1280-3875 124 µM -0.992762617685237 0.169948458280878 no 2805 0.160412825695694 4088 373245 SGTC_2803 7707263 71.43 µM -0.993536124828369 0.169761964380852 no 2806 0.160224377426653 4054 2199229 SGTC_1142 3253-1408 9.78 µM -0.994825435629027 0.169451401156382 no 2807 0.159910586525047 4086 256655 SGTC_2905 7799065 20.05 µM -0.996473014584681 0.169055070938418 no 2808 0.15951018615732 4010 1296806 SGTC_1192 1488-0095 21.4 µM -0.996768036537218 0.16898416539064 no 2809 0.159438558233191 4140 915875 SGTC_1326 1431-2094 10.8 µM -0.998551834237225 0.168555854620908 no 2810 0.159005921378786 4068 616278 SGTC_247 mechlorethamine 29.705 µM -0.999732182383412 0.168272823214455 no 2811 0.158720066632011 3975 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2747 doxorubicin 7.63 µM -1.00137834131823 0.167878607514625 no 2812 0.158321965534967 4047 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2526 patulin 37.61 µM -1.00180209469297 0.167777225013176 no 2813 0.158219592678177 4126 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2462 5162487 171.77 µM -1.00235522757263 0.167644947943245 no 2814 0.15808602892621 3985 2259986 SGTC_1621 st003705 32.4 µM -1.00328875569999 0.167421854937905 no 2815 0.157860779896887 4098 24207032 SGTC_2755 lomerizine 42.69 µM -1.00426662967939 0.167188369474049 no 2816 0.157625056883125 4061 3949 A calcium channel blocker. SGTC_1337 1486-1011 40.3 µM -1.00438840570121 0.167159307905817 no 2817 0.157595718165741 4065 X1337 SGTC_2206 7254556 146.969 µM -1.00476979667415 0.167068310898947 no 2818 0.157503855297152 4089 4398905 SGTC_2916 7875993 68.79 µM -1.00654850252878 0.166644347059502 no 2819 0.157075896194442 3943 1299250 SGTC_3002 9075603 71.4286 µM -1.00753336463424 0.166409898949798 no 2820 0.156839266278791 4034 20105405 SGTC_1062 mesoridazine 14.2 µM -1.00860162995639 0.166155837464437 no 2821 0.156582862658241 4105 4078 A neuroleptic. SGTC_2020 4017018 200 µM -1.0087685437793 0.166116163629551 no 2822 0.156542825166311 4175 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1757 st041620 31.8375 µM -1.01126029864809 0.165524624821324 no 2823 0.155945931243256 4171 5289815 SGTC_33 0986-0033 35.816 µM -1.01426586002264 0.164812924309996 no 2824 0.155227954920351 4062 2848082 SGTC_1182 1222-0449 220 µM -1.01617604061143 0.164361635703581 no 2825 0.154772781837653 4105 658318 SGTC_373 0844-0104 25.9 µM -1.01799567118673 0.163932485724535 no 2826 0.15434000663476 4126 5375804 SGTC_1231 0242-0792 125 µM -1.01896184107954 0.163704915593786 no 2827 0.15411054136888 4102 3707635 SGTC_268 camptothecin 39.6153 µM -1.02024420840741 0.163403185710183 no 2828 0.153806327968791 4086 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1162 k048-0130 20.1 µM -1.02055886686279 0.16332920453981 no 2829 0.153731742954969 4068 6797406 SGTC_13 0199-0087 65 µM -1.02315235995647 0.162720262336549 no 2830 0.153117906849872 4167 4589825 SGTC_129 0088-0017 176.636 µM -1.02527230469204 0.162223605768076 no 2831 0.152617359938026 3973 182446 SGTC_1501 4491-0275 38.4 µM -1.02572217487138 0.162118338127516 no 2832 0.152511279439748 4085 5104718 SGTC_2533 agelasine 13.65 µM -1.02701227358317 0.161816707464181 no 2833 0.15220734237801 4181 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2792 7535235 81.82 µM -1.0272437377322 0.161762628859195 no 2834 0.152152853833089 4127 1281891 SGTC_1314 1222-0010 41.1 µM -1.02942800428844 0.161252883286562 no 2835 0.151639297603802 4120 3526027 SGTC_2483 5729050 27.16 µM -1.03093011987202 0.160902941057013 no 2836 0.151286795424355 4146 2865180 SGTC_466 geldanamycin 89.2 µM -1.03093765674722 0.160901186470348 no 2837 0.151285028117577 4051 5288382 HSP90 inhibitor. SGTC_3265 9137266 49.47 µM -1.03181044880254 0.160698084705103 no 2838 0.151080461724687 4039 17224265 SGTC_762 1165-0429 115 µM -1.03183977915103 0.160691262339309 no 2839 0.151073590428937 4135 5967793 SGTC_353 1988-1175 58.3 µM -1.032797462236 0.160468605035709 no 2840 0.150849345807445 3962 2788357 SGTC_845 0330-0138 4.51 µM -1.03467476870558 0.160032724272412 no 2841 0.150410411571249 4094 9039800 SGTC_899 1083-0020 478 µM -1.03621852705674 0.159674868730477 no 2842 0.150050102640771 4186 767123 SGTC_2866 9034245 58.44 µM -1.03700249034141 0.159493340398767 no 2843 0.149867348275704 4088 6462273 SGTC_2015 5119600 184 µM -1.04020967091182 0.158752118401242 no 2844 0.149121249716507 4168 2828786 SGTC_1711 st032263 62.8 µM -1.04123271517323 0.158516155111179 no 2845 0.148883777840205 4139 3958979 SGTC_710 3448-4187 58 µM -1.04131550214409 0.158497070513044 no 2846 0.148864572156251 4112 3946412 SGTC_2738 aclarubicin 5.55 µM -1.04464021751305 0.15773188079646 no 2847 0.148094642276615 4094 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2814 7977482 42.97 µM -1.0448188994378 0.15769082562903 no 2848 0.148053339124882 4195 6456762 SGTC_949 1165-0505 146 µM -1.04628033764238 0.157355299234091 no 2849 0.147715810347113 4154 6244267 SGTC_442 cape 100 µM -1.04658242775467 0.157286002012737 no 2850 0.147646104966903 4127 5281787 SGTC_676 falcarinol 140 µM -1.04665714882945 0.157268864650354 no 2851 0.147628866951306 4158 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_151 3013-0144 2.285 µM -1.04715581315074 0.157154526864153 no 2852 0.147513860520783 4021 906558 YHR107C CDC12 SGTC_1357 1503-1303 39.5 µM -1.0480807752828 0.156942588842547 no 2853 0.147300696435316 4101 292895 SGTC_2299 7976368 114.88 µM -1.05050937395902 0.156387015631169 no 2854 0.146741991713228 4178 2979718 SGTC_2982 9019404 25.97 µM -1.05083251029231 0.156313191790818 no 2855 0.146667760771211 4078 22333232 SGTC_3096 9117468 49.47 µM -1.05223683435552 0.155992626116268 no 2856 0.146345451915793 4033 41316311 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.05249786466117 0.155933088402383 no 2857 0.146285594851273 4214 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1382 3002-2117 298 µM -1.05350839751331 0.15570273988789 no 2858 0.146054023805074 4218 1497314 SGTC_2918 7977171 22.06 µM -1.0549668427576 0.155370686672827 no 2859 0.145720244756472 4135 2236483 SGTC_1989 st071868 50.2 µM -1.05505179612414 0.155351359229809 no 2860 0.145700818188508 4132 16414057 SGTC_844 0330-0132 15.3 µM -1.05676752642335 0.154961359046687 no 2861 0.145308849102716 4199 2828079 SGTC_1264 0783-0040 158 µM -1.06059420564563 0.154093853370812 no 2862 0.144437178490088 4035 2855798 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.06116485027864 0.153964764407696 no 2863 0.144307495175225 4151 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1221 2958-7315 257 µM -1.06233282520325 0.15370077293635 no 2864 0.144042308802708 4193 4562705 SGTC_376 3970-0862 59.1 µM -1.06527657550628 0.153036742115994 no 2865 0.143375394900924 4201 3135186 SGTC_554 4483-2211 187 µM -1.06554292875682 0.152976753952221 no 2866 0.143315154940017 4207 747107 SGTC_1065 prochlorperazine maleate 2.48 µM -1.06618259427563 0.152832751964318 no 2867 0.143170554381995 4193 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1033 k072-0102 21.3 µM -1.06733332807842 0.152573924281383 no 2868 0.142910671699557 4129 5965931 SGTC_3208 9114115 49.47 µM -1.06808447056278 0.152405131255716 no 2869 0.142741205129056 4183 650895 SGTC_718 1130-0073 349 µM -1.07024343300737 0.151920670178526 no 2870 0.142254874474255 4195 6740020 SGTC_2772 vinpocetine 57.06 µM -1.07324520683445 0.151248788024458 no 2871 0.141580556179015 4203 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3240 9133527 49.47 µM -1.07517801007356 0.150817219462637 no 2872 0.141147519304686 4111 17617455 SGTC_831 k061-1017 217 µM -1.07547379813172 0.150751246430293 no 2873 0.141081328487146 4192 1240153 SGTC_1207 2099-0101 141 µM -1.07796600694694 0.150196143340156 no 2874 0.140524463228937 4178 5837381 SGTC_2394 5221648 200 µM -1.07937927683256 0.149881964234294 no 2875 0.140209342600632 4213 788586 SGTC_2447 5741742 33.78 µM -1.08097025625267 0.149528803943676 no 2876 0.139855172320675 4233 1776504 SGTC_848 0368-0089 85.6 µM -1.08271215053771 0.149142781440416 no 2877 0.139468104562567 4176 762535 SGTC_1008 4106-0037 6 µM -1.08321932631206 0.149030511053777 no 2878 0.139355541714873 4151 2905394 SGTC_3257 9139206 32.98 µM -1.08535356594325 0.148558686315895 no 2879 0.138882544893138 4175 4910041 SGTC_2105 5350118 200 µM -1.08558899405905 0.148506700528734 no 2880 0.138830435608365 4148 2133313 SGTC_1672 st016598 6.51 µM -1.08607490765377 0.148399442547658 no 2881 0.138722926370742 4186 4665860 YNL267W PIK1 SGTC_1324 1418-0026 34.4 µM -1.08675970201513 0.14824837266489 no 2882 0.138571510709118 4215 1372513 SGTC_2308 7584454 197.62 µM -1.08726338060441 0.148137323734735 no 2883 0.138460213657426 4243 893577 SGTC_2426 5582046 32.21 µM -1.08735192549482 0.148117807485183 no 2884 0.138440654332316 4194 2251934 SGTC_1506 4226-2149 212 µM -1.08765269113963 0.14805152833937 no 2885 0.138374230082027 4190 991114 SGTC_1713 st033146 12.748 µM -1.08793443448682 0.147989459109229 no 2886 0.138312026624222 4181 674619 SGTC_3277 9138724 49.47 µM -1.09009279752086 0.147514540624375 no 2887 0.137836134340595 4146 15943418 SGTC_3237 9133362 49.47 µM -1.09043865421877 0.147438534575046 no 2888 0.137759981200617 4160 43845137 SGTC_1796 st049173 110.4 µM -1.09424542885601 0.146603685402316 no 2889 0.136923676038202 4144 94134 SGTC_761 k216-0224 480 µM -1.09764540261944 0.145860737290992 no 2890 0.136179679501053 4226 1340404 SGTC_937 3122-0005 46.7 µM -1.1010566191442 0.145117879604537 no 2891 0.135436007927376 4213 759535 SGTC_258 haloperidol 50.781 µM -1.10139409870099 0.145044525629358 no 2892 0.135362586357626 4182 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3119 9125183 49.47 µM -1.10331863724055 0.144626688282739 no 2893 0.134944407923527 4009 22695334 SGTC_2514 salinomycin 42.74 µM -1.10357532899257 0.144571019180024 no 2894 0.134888699030047 4240 23682228 A polyether potassium ionophore. SGTC_2239 6685329 187.64 µM -1.10440383215755 0.144391439030081 no 2895 0.134708999598034 4255 805680 SGTC_1905 st060207 84.5 µM -1.10512639288147 0.144234944947722 no 2896 0.134552412881141 4171 1948547 SGTC_3272 9137413 49.47 µM -1.10726673564747 0.143772055121821 no 2897 0.134089310869974 4112 17614870 SGTC_1903 st060211 78.3 µM -1.10911300950362 0.143373569357376 no 2898 0.133690716669665 4234 688960 SGTC_1125 tnp00248 1.32998 µM -1.11115444605097 0.142933830109729 no 2899 0.133250937774657 4274 24207736 SGTC_2780 5215298 71.43 µM -1.11312165194539 0.142510943844716 no 2900 0.132828092863207 4235 2834131 SGTC_830 4076-0286 57.8 µM -1.11356508973202 0.1424157359121 no 2901 0.132732905018518 4273 6866659 SGTC_1219 1469-0211 33.1 µM -1.11808383357882 0.141447996119294 no 2902 0.131765595152306 4239 6822282 SGTC_1283 0922-0125 16.4 µM -1.11909355223198 0.141232364100048 no 2903 0.131550115139914 4210 3360884 SGTC_1622 st003707 19.4 µM -1.11919684551866 0.141210317715306 no 2904 0.131528085454864 4224 10140899 SGTC_359 0081-0058 15.9 µM -1.12084874817054 0.140858061176764 no 2905 0.131176124942713 4317 3494159 SGTC_1457 k015-0032 57.3 µM -1.1210041153189 0.140824960931485 no 2906 0.131143055342117 4206 4302660 SGTC_3218 9131285 49.47 µM -1.12155288312421 0.140708090754461 no 2907 0.131026297257136 4184 17156417 SGTC_1392 3455-1037 33.9 µM -1.12180109289787 0.140655251550985 no 2908 0.130973510725007 4211 981132 SGTC_1556 plumbagin 1.48 µM -1.12252638604762 0.140500927425452 no 2909 0.13081934754359 4131 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1300 1094-0077 113 µM -1.12259277202112 0.14048680790567 no 2910 0.130805243278302 4198 5532636 SGTC_3175 9106517 49.47 µM -1.12515741426005 0.13994207589982 no 2911 0.130261167684562 4233 41468073 SGTC_2771 fluoxetine 41.05 µM -1.12615335206737 0.139730925389778 no 2912 0.130050307291507 4228 3386 A selective serotonin reuptake inhibitor. SGTC_1273 0849-0096 14.1 µM -1.12816918956955 0.139304207340119 no 2913 0.129624236602457 4241 5286025 SGTC_1285 0929-0069 65.5 µM -1.12956812189841 0.139008599167653 no 2914 0.129329124919604 4239 1206237 SGTC_1420 4'-methoxyflavone 42 µM -1.13157332911606 0.13858562438438 no 2915 0.128906929149965 4218 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_824 1304-0008 100 µM -1.13577999469611 0.137701129740588 no 2916 0.128024325811518 4247 768245 SGTC_478 N-arachidonylglycine 10 µM -1.13706329889319 0.137432070416588 no 2917 0.127755912542345 4201 5283389 SGTC_2994 9053520 71.4286 µM -1.13754582860444 0.137330995493767 no 2918 0.127655088874222 4276 4647384 SGTC_3049 9092223 49.47 µM -1.14019803435506 0.13677634755705 no 2919 0.127101903120382 4203 8623917 SGTC_935 2996-0153 430 µM -1.14043749256036 0.136726345850062 no 2920 0.127052040179448 4233 23738523 SGTC_1048 3161-0300 24.5 µM -1.1412900729558 0.136548418441406 no 2921 0.126874615903992 4230 2165101 SGTC_2879 9041815 71.43 µM -1.14206223336006 0.136387410816644 no 2922 0.126714076156319 4246 4942971 SGTC_3166 9102297 49.47 µM -1.1425078798371 0.136294545628208 no 2923 0.126621486273452 4226 25237072 SGTC_1571 st070080 73.4 µM -1.14279216919558 0.136235327142069 no 2924 0.12656244542707 4262 4315245 SGTC_1447 4239-0816 81.9 µM -1.14436760135449 0.135907478166855 no 2925 0.126235609294436 4238 1341554 SGTC_270 tamoxifen 5.46 µM -1.14443189107144 0.135894110895785 no 2926 0.126222284377016 4292 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2595 hexamethylquercetagetin 100 µM -1.14540499021006 0.135691891740231 no 2927 0.12602071606773 4227 386331 SGTC_972 1319-0219 195 µM -1.14916622339409 0.134912210751479 no 2928 0.125243722805727 4213 23903702 SGTC_1278 0874-0585 172 µM -1.15560348725174 0.133584947140929 no 2929 0.12392169048601 4316 766306 SGTC_2285 7945142 200 µM -1.15589106106288 0.133525864152915 no 2930 0.123862859708279 4286 2970608 SGTC_3313 9133968 57.047 µM -1.15706060344585 0.133285762996164 no 2931 0.123623800528278 4243 1494643 SGTC_81 0411-0046 9.971 µM -1.15840847523058 0.133009420361533 no 2932 0.123348691074413 4204 12925265 SGTC_206 4546-0025 72.014 µM -1.16114583372377 0.132449417659233 no 2933 0.122791299091848 4301 6620745 YIL048W NEO1 SGTC_1687 st020778 55.3625 µM -1.16254461595613 0.132163886020218 no 2934 0.122507156375263 4255 4259299 SGTC_1088 bifonazole 369 nM -1.16333343231831 0.13200305321752 no 2935 0.122347123152618 4221 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_465 cgp-37157 41 µM -1.16454115931322 0.131757069807119 no 2936 0.122102386724116 4232 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2829 7992743 58.44 µM -1.16723795194712 0.131208943547033 no 2937 0.121557144153032 4250 16462845 SGTC_2981 9013952 38.96 µM -1.16771364506728 0.131112422002282 no 2938 0.121461145463472 4234 2996344 SGTC_3086 9117350 49.47 µM -1.16776175615607 0.131102662649367 no 2939 0.121451439228257 4192 2679265 SGTC_3230 9131665 49.47 µM -1.1678240331871 0.131090030474833 no 2940 0.121438875876074 4235 15943720 SGTC_3207 9114163 49.47 µM -1.17402333106227 0.129836780644248 no 2941 0.120192840307713 4286 849233 SGTC_443 clozapine 122 µM -1.17971464834582 0.128693550105974 no 2942 0.119056862929175 4224 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3108 9121785 49.47 µM -1.17993892994193 0.128648641539804 no 2943 0.119012252475039 4088 17140271 SGTC_2375 9072683 200 µM -1.18181405668543 0.128273604878743 no 2944 0.118639744513439 4352 16798029 SGTC_3041 9091929 49.47 µM -1.18241093204316 0.128154385652436 no 2945 0.118521343792838 4276 25236887 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.18342993341539 0.127951029327328 no 2946 0.118319399983147 4272 5024745 SGTC_130 0136-0219 337.655 µM -1.18530514518257 0.127577390110406 no 2947 0.117948409961561 4103 234244 SGTC_2787 5284540 71.43 µM -1.18926111067801 0.126791647087694 no 2948 0.117168466765401 4306 736958 SGTC_669 0108-0021 26.2 µM -1.19004649406028 0.126636054154119 no 2949 0.117014059239953 4256 17201 SGTC_2002 4023503 131 µM -1.19390179501174 0.125874206134575 no 2950 0.116258192646023 4278 4736863 YCR052W RSC6 SGTC_2445 5742597 35.57 µM -1.19394700846351 0.125865290485204 no 2951 0.116249348742305 4274 1774255 SGTC_2187 6125751 200 µM -1.19561645863172 0.125536399602876 no 2952 0.115923132842456 4282 874498 SGTC_2720 fluspirilene 36.88 µM -1.20035061161817 0.124607008791904 no 2953 0.115001600656732 4264 3396 An atypical antipsychotic. SGTC_2702 st077768 96.8 µM -1.20205947874981 0.124272714906426 no 2954 0.114670242221879 4266 6484119 SGTC_921 1561-0023 372 µM -1.20374132601878 0.123944319715713 no 2955 0.114344787006955 4258 24050882 SGTC_3033 9090887 49.47 µM -1.20490930580151 0.123716619224408 no 2956 0.114119157881596 4295 19325384 SGTC_3017 9080681 49.47 µM -1.20524869630993 0.123650509173584 no 2957 0.114053654278107 4313 16451914 SGTC_2909 7941780 10.49 µM -1.20885215188793 0.122950115622705 no 2958 0.113359825718513 4278 1243215 SGTC_2946 9065502 71.43 µM -1.21040284399469 0.122649569606693 no 2959 0.113062175568957 4120 16489101 SGTC_763 3453-1109 128 µM -1.21312555756922 0.122123116908841 no 2960 0.112540909983932 4321 1560353 SGTC_73 0327-0325 16.231 µM -1.21395939495507 0.121962207377546 no 2961 0.112381615082234 4141 53298 SGTC_911 3456-4043 236 µM -1.2192195028616 0.120950572067196 no 2962 0.111380445781371 4301 914281 SGTC_1093 fluphenazine 7.97 µM -1.21947488755515 0.120901606670331 no 2963 0.111332000802999 4323 6602611 An atypical antipsychotic. SGTC_4 0960-0234 25.671 µM -1.22757994472594 0.119354850133892 no 2964 0.10980234710728 4328 6821112 SGTC_2366 9070441 60.58 µM -1.22820484051168 0.119236178455438 no 2965 0.109685041037026 4285 6837235 SGTC_1798 st045719 60.953 µM -1.23074015955087 0.118755559722898 no 2966 0.109210031419391 4257 3980186 SGTC_1030 k029-0042 36.7 µM -1.23158289046947 0.118596107253761 no 2967 0.109052467715798 4291 6080581 SGTC_565 1418-0001 44.5 µM -1.23245172427745 0.118431874326196 no 2968 0.108890194728779 4367 2862145 SGTC_673 1082-0474 110 µM -1.2333012937973 0.118271438378947 no 2969 0.108731687688082 4318 3098046 SGTC_2629 bisabolol 100 µM -1.23410722810367 0.118119384758352 no 2970 0.108581475239999 4341 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1141 3253-0389 52.6 µM -1.23479010225349 0.117990656832688 no 2971 0.108454315981446 4308 5402031 SGTC_1385 3091-4834 14.1 µM -1.23482299242263 0.117984459245654 no 2972 0.108448194147813 4283 4072814 SGTC_919 tnp00227 403.569 nM -1.23490100448467 0.117969760134381 no 2973 0.108433674789057 4269 1269246 A methoxyflavone. YNL221C POP1 SGTC_299 1273-0059 1.44 µM -1.23501323390892 0.117948616025782 no 2974 0.108412789456295 4123 2848077 SGTC_2213 7173844 200 µM -1.23733043942578 0.117512651775924 no 2975 0.10798221580167 4310 892728 SGTC_551 k048-0028 34.9 µM -1.23801300179493 0.117384450759061 no 2976 0.107855619950326 4288 6836383 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.23825398087771 0.117339212972893 no 2977 0.107810950745543 4327 551469 SGTC_116 0155-0182 31.788 µM -1.23963606880866 0.117079999056693 no 2978 0.107555016706765 4199 771486 SGTC_2035 5154463 94.595 µM -1.23970476386003 0.117067125727339 no 2979 0.107542307238346 4333 2769623 SGTC_3231 9132313 49.47 µM -1.23993254409907 0.117024447295681 no 2980 0.107500172707237 4258 4905967 SGTC_1220 1838-0075 193 µM -1.24147685602228 0.116735385426647 no 2981 0.107214821371792 4245 5529645 SGTC_3 0833-0587 95.581 µM -1.24214017031341 0.116611382843286 no 2982 0.107092424818922 4202 5382644 SGTC_1084 voriconazole 435 nM -1.24321700174912 0.116410274698987 no 2983 0.106893939604444 4332 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_587 k089-0003 57 µM -1.2448657754564 0.116102828063203 no 2984 0.10659054656542 4239 9659696 SGTC_2926 9010726 65.15 µM -1.24585817586424 0.115918053358153 no 2985 0.106408233576942 4333 2994293 SGTC_1461 k072-0203 53.8 µM -1.25321156442289 0.114555431809231 no 2986 0.105064361212029 4235 5418714 SGTC_3060 1327-0027 12.5 µM -1.25325072954175 0.114548204958961 no 2987 0.105057236610216 4248 16000455 YPR107C YTH1 SGTC_2898 9056270 58.44 µM -1.25508910175271 0.114209348726926 no 2988 0.104723208133186 4338 19154699 SGTC_958 1222-0007 33 µM -1.25690556781431 0.113875232105915 no 2989 0.104393916078306 4400 7312461 SGTC_3045 9092950 49.47 µM -1.25733593536375 0.113796173446894 no 2990 0.104316008378595 4312 44120432 SGTC_2840 9008771 71.43 µM -1.25931355670289 0.113433386651516 no 2991 0.103958549247762 4274 2992978 SGTC_495 decylubiquinone 155 µM -1.2597101759138 0.113360727838539 no 2992 0.103886966574305 4344 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2988 9073640 71.4286 µM -1.26054217421602 0.113208417450356 no 2993 0.103736921927461 4385 9102229 SGTC_1012 4112-3522 18 µM -1.2618967537537 0.112960752797807 no 2994 0.103492970137254 4343 3112398 SGTC_3149 9097855 49.47 µM -1.26309672931723 0.112741678418794 no 2995 0.103277209644405 4336 25236625 YMR079W SEC14 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.26695558643031 0.11203924035041 no 2996 0.102585585556038 4352 77254 SGTC_2789 5281112 71.43 µM -1.26843038812247 0.111771606405856 no 2997 0.1023221476787 4353 765948 SGTC_1161 k007-0610 110 µM -1.27023787774217 0.111444223245546 no 2998 0.101999954535091 4305 5843850 SGTC_1389 3405-0187 19 µM -1.27264961201452 0.111008465309807 no 2999 0.101571202647593 4315 799890 SGTC_1941 st076221 61.8 µM -1.27343257135488 0.110867261086149 no 3000 0.101432292759096 4222 2828568 SGTC_1353 1498-1206 8.11 µM -1.2737623093561 0.110807832410937 no 3001 0.10137383323301 4378 6756808 SGTC_1345 1488-0192 31.4 µM -1.27567811362614 0.110462998558253 no 3002 0.101034664218379 4391 658348 SGTC_2144 5628481 200 µM -1.27623783659118 0.110362396989372 no 3003 0.100935728626244 4330 2818399 SGTC_922 1866-0035 480 µM -1.27835056343268 0.109983258962271 no 3004 0.100562923407456 4267 3156169 SGTC_3238 9133470 49.47 µM -1.27877941366153 0.109906414164302 no 3005 0.100487372628604 4354 3534688 SGTC_3342 9147791 14.508 µM -1.28157683918622 0.109406094498223 no 3006 0.0999955645898845 4314 1838168 SGTC_3180 9109287 49.47 µM -1.28212938224496 0.109307465928296 no 3007 0.0998986316749169 4393 18891271 SGTC_801 0866-0028 10.1 µM -1.28424065896057 0.108931192780473 no 3008 0.0995288814128698 4362 6849771 SGTC_2382 9035899 200 µM -1.28428195322619 0.108923842584384 no 3009 0.0995216594877168 4338 6462679 SGTC_2149 5554786 194.827 µM -1.28715518627991 0.108413294980724 no 3010 0.0990201017426784 4384 745063 YPR165W RHO1 SGTC_1242 0402-0103 60.1 µM -1.28892483280265 0.10809970284684 no 3011 0.0987121099545618 4281 432868 SGTC_979 1426-2828 121 µM -1.29551030460885 0.106938454860295 no 3012 0.0975721244625763 4445 747872 SGTC_2605 digitonin 300 nM -1.30347147390392 0.105546672665294 no 3013 0.0962069245346261 4372 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_163 TUB2.036 7.546 µM -1.30418706189451 0.10542221724482 no 3014 0.0960849050586655 4320 15992207 YJR013W GPI14 SGTC_2196 6573537 42.6665 µM -1.31023928914808 0.104373854443449 no 3015 0.0950574491544685 4391 2903087 SGTC_2456 5770359 74.46 µM -1.31307678328254 0.103884955256548 no 3016 0.0945785380947232 4381 3118787 SGTC_2050 5263056 171 µM -1.31427698913991 0.103678660853579 no 3017 0.0943765040142182 4355 763468 YGL055W OLE1 SGTC_1795 st049545 62.3 µM -1.31494782856553 0.103563484859457 no 3018 0.0942637184459545 4320 5291882 SGTC_452 diindolylmethane 8 µM -1.32191017826959 0.102373602514844 no 3019 0.0930990313568552 4375 3071 Inhibits expression of several cancer promoting factors. SGTC_2490 carminic acid 95.39 µM -1.32283390141373 0.10221648604526 no 3020 0.0929453102468356 4344 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1814 st052110 31.539 µM -1.32394634283646 0.102027503307187 no 3021 0.0927604327998557 4311 674163 SGTC_1647 st011722 22.4 µM -1.32427804227 0.101971203089219 no 3022 0.09270536009828 4346 2854783 SGTC_704 1310-0270 142 µM -1.32544167412286 0.101773875568617 no 3023 0.0925123512588271 4382 5718033 SGTC_1824 st053723 68.6 µM -1.33496010142695 0.100170179097739 no 3024 0.0909447026324593 4399 675225 SGTC_1948 st076329 66.6 µM -1.33646724579911 0.099917951530234 no 3025 0.0906982997260356 4305 24208413 SGTC_164 4100-3994 89.624 µM -1.33676488976711 0.0998681943335194 no 3026 0.0906496965807147 4383 4615967 SGTC_2545 solidagenone 89.61 µM -1.33948410492014 0.099414460352108 no 3027 0.0902065628072607 4282 6708572 An anti ulcer agent SGTC_1363 1636-0063 10.4 µM -1.34086201114174 0.0991851160999116 no 3028 0.0899826291103055 4397 6072185 SGTC_3162 9099653 49.47 µM -1.34096806572605 0.099167479997486 no 3029 0.0899654105342388 4378 25237511 SGTC_1833 st055984 71 µM -1.34195791876525 0.0990029852478341 no 3030 0.0898048202173249 4403 676288 SGTC_3087 9117406 49.47 µM -1.34228387656346 0.0989488609707352 no 3031 0.0897519846209134 4419 42546093 SGTC_2965 9082772 38.63 µM -1.34265568533134 0.0988871497152087 no 3032 0.0896917451035063 4400 16459634 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.34295334528852 0.0988377656669136 no 3033 0.08964354065843 4301 17037758 SGTC_2802 7925815 54.55 µM -1.34378402853866 0.0987000444612247 no 3034 0.0895091178216014 4375 1262923 SGTC_2504 purpurogallin 52.29 µM -1.34480664862849 0.098530694478276 no 3035 0.0893438413178627 4305 5281571 An antioxidant. SGTC_2685 mycophenolic acid 18.85 µM -1.34570920339795 0.0983814046104966 no 3036 0.0891981585513945 4397 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_898 1000-0849 28.3 µM -1.3476128346939 0.0980670718382484 no 3037 0.0888914701696108 4412 6751807 SGTC_3246 9135460 32.98 µM -1.34974211286337 0.0977163522231576 no 3038 0.0885493594346622 4365 41446951 SGTC_2430 5571206 200 µM -1.35189948233726 0.0973619443636977 no 3039 0.0882037365902537 4386 1731771 SGTC_3293 9120939 62.045 µM -1.3527087835748 0.0972292376690747 no 3040 0.0880743416265339 4389 934087 SGTC_1828 st055811 49 µM -1.35469984668912 0.0969033143887297 no 3041 0.0877566033795045 4414 5877589 SGTC_2770 toltrazuril 17.5 µM -1.35649149953593 0.0966107194777849 no 3042 0.0874714190859784 4345 68591 Kills coccidiodes. SGTC_1075 aripiprazole 15.2 µM -1.35721519821113 0.0964927164063052 no 3043 0.0873564215052197 4455 60795 An atypical antipschotic. YIL048W NEO1 SGTC_821 1114-0266 29.2 µM -1.35762266780891 0.096426322849763 no 3044 0.0872917232188101 4427 3123235 SGTC_3261 9137475 49.47 µM -1.35823698656258 0.0963262885222819 no 3045 0.0871942489231959 4402 17027690 SGTC_2587 piperic acid 92.2 µM -1.35937339940565 0.0961414386114052 no 3046 0.0870141479442842 4362 5370536 SGTC_568 1193-0097 7.48 µM -1.36006395183169 0.0960292402036492 no 3047 0.0869048436219527 4207 3646150 SGTC_674 0498-0004 451 µM -1.36240812513086 0.0956490857642367 no 3048 0.0865345604779959 4395 4231473 SGTC_156 3474-0145 5.642 µM -1.36469185549003 0.0952797993522079 no 3049 0.0861749602729204 4331 2265471 SGTC_323 4013-0906 34.3 µM -1.36572290789975 0.0951134193025869 no 3050 0.0860129756801857 4424 2910086 SGTC_847 0342-0274 5.54 µM -1.36619508948725 0.0950372952368836 no 3051 0.0859388691901968 4403 18097 SGTC_3048 9093155 49.47 µM -1.36724684632994 0.0948678946649062 no 3052 0.0857739730811929 4373 25236002 SGTC_1325 1431-0015 227 µM -1.36906208178976 0.0945760483966275 no 3053 0.0854899348812526 4429 1103340 SGTC_2219 9098279 200 µM -1.37211749130302 0.0940863073992184 no 3054 0.0850134325876382 4359 902349 SGTC_1658 st012944 20 µM -1.37342079537839 0.0938779755451205 no 3055 0.0848107843038009 4255 24207260 SGTC_418 lividomycin a 100 µM -1.37465332768651 0.0936812699181923 no 3056 0.0846194736208552 4433 72394 An antibiotic. SGTC_2139 5578692 56.4705 µM -1.37748202145069 0.0932309763145246 no 3057 0.0841816347539707 4398 650991 YMR113W FOL3 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.37910043185746 0.0929740654173717 no 3058 0.0839318953654149 4443 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.37934931849748 0.092934602945688 no 3059 0.0838935386978796 4414 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_989 1501-0895 10.3 µM -1.37996189584721 0.0928375278754844 no 3060 0.0837991886382867 4395 2830112 SGTC_2238 6671620 73.2395 µM -1.3812235783507 0.0926378254545586 no 3061 0.0836051136147723 4337 729941 SGTC_2123 5259487 200 µM -1.38734962374749 0.0916726943595769 no 3062 0.0826675891057395 4445 2173474 SGTC_1197 1601-0112 267 µM -1.39296831988588 0.0907940622280457 no 3063 0.0818146854256364 4401 7350313 SGTC_3203 9113543 49.47 µM -1.39505929368619 0.0904686835115653 no 3064 0.0814989800063076 4459 17018012 SGTC_567 1080-0542 68.4 µM -1.39844891099109 0.0899430619959735 no 3065 0.0809891521075144 4321 5950415 SGTC_2690 usnic acid 100 µM -1.40054544130686 0.0896190949505531 no 3066 0.0806750228667506 4436 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1877 wortmannin 25 µM -1.40359397845126 0.0891495679970392 no 3067 0.0802198946224415 4459 312145 A covalent inhibitor of PI 3-kinase. SGTC_370 0180-0345 38.7 µM -1.40581901129206 0.0888080321880077 no 3068 0.0798889376237615 4277 3989527 SGTC_3312 9133330 71.43 µM -1.40779531484477 0.0885054934119532 no 3069 0.0795958440520503 4450 17617324 SGTC_3010 9080089 71.4286 µM -1.40799516125394 0.0884749430938122 no 3070 0.0795662514001141 4454 17027233 SGTC_2541 muurolladie-3-one 83.07 µM -1.41044467920121 0.0881011258705077 no 3071 0.079204210260954 4390 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2645 abamectin 100 µM -1.41387824586867 0.087579118298239 no 3072 0.0786988271376369 4395 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_430 0958-0115 16.4 µM -1.41421847114443 0.0875275195508449 no 3073 0.0786488831032886 4373 6833180 SGTC_1974 st069448 26.9 µM -1.41549774418675 0.087333707337124 no 3074 0.0784613046711692 4436 6323587 YNR016C ACC1 SGTC_343 4130-2827 29.8 µM -1.41800656858583 0.0869545463741436 no 3075 0.078094423522457 4428 1118244 SGTC_506 n9-isopropylolomoucine 153 µM -1.42055508765889 0.086570646717812 no 3076 0.0777230715147721 4441 6610355 SGTC_2188 6126565 140.678 µM -1.42409818599711 0.0860390342806275 no 3077 0.0772090257329923 4356 874518 SGTC_3248 9135562 49.47 µM -1.42426035055583 0.0860147614222353 no 3078 0.0771855602674698 4446 17650701 SGTC_546 peri-Naphthalide 147 µM -1.42909329424845 0.0852937141502241 no 3079 0.0764887103104732 4405 223824 A penicillin ester. SGTC_1736 st036774 51 µM -1.43142889610922 0.0849468830773587 no 3080 0.0761536658645642 4501 1272247 SGTC_1714 st033236 13.627 µM -1.43383615591397 0.0845905184541865 no 3081 0.0758095122496303 4460 2916566 SGTC_2756 carbadox 75.1 µM -1.43403556925802 0.0845610481795564 no 3082 0.0757810563582968 4388 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1007 4101-0031 70 µM -1.44067446508657 0.0835843106788155 no 3083 0.0748383360512882 4441 1146276 SGTC_3249 9135183 49.47 µM -1.4436792049137 0.0831450396892011 no 3084 0.0744146167865164 4430 4902779 SGTC_2402 5553605 200 µM -1.4464866529145 0.0827361821742369 no 3085 0.0740203764740904 4512 6758546 SGTC_1654 st012436 41.8 µM -1.4468567801574 0.0826823924500878 no 3086 0.0739685200517136 4458 4323132 SGTC_2929 9013348 24.6 µM -1.4503799575835 0.0821716942446191 no 3087 0.0734762965008776 4434 2995952 SGTC_2476 5806916 10.51 µM -1.45059228552898 0.0821409925686534 no 3088 0.0734467123591138 4385 2870194 SGTC_283 0987-0079 11.7 µM -1.4524733817116 0.0818693717188034 no 3089 0.0731850126211563 4471 411556 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.4634564340308 0.080296972589599 no 3090 0.0716712631377282 4481 7104 SGTC_2263 7948595 193.29 µM -1.46439668919062 0.0801634279514604 no 3091 0.071542796106506 4493 2971371 SGTC_1236 0330-0013 258 µM -1.46590976676674 0.0799488777779823 no 3092 0.0713364354142504 4496 4617066 SGTC_3322 9139058 2.11 µM -1.46608105939034 0.0799246163486842 no 3093 0.0713131025339918 4508 4908926 YPR165W RHO1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.46633188308997 0.0798891003958775 no 3094 0.071278946780049 4449 442882 SGTC_2292 7671323 168.05 µM -1.46649613488183 0.079865849257179 no 3095 0.0712565867048391 4491 937504 SGTC_3150 9097574 49.47 µM -1.46925893450809 0.0794755197804268 no 3096 0.0708812853157033 4515 17217476 SGTC_559 1550-0661 158 µM -1.47010667203007 0.0793560409927911 no 3097 0.070766432804688 4513 5830875 SGTC_3142 9086498 49.47 µM -1.47372361577355 0.078847801800389 no 3098 0.0702780108538022 4341 25236367 SGTC_2776 terbinafine 19.92 µM -1.47621708918941 0.0784988670200853 no 3099 0.0699428116596474 4489 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3289 9119912 71.43 µM -1.47714848470857 0.0783688289591971 no 3100 0.0698179196423283 4479 17014829 SGTC_2013 4024628 200 µM -1.47790822332087 0.0782628780222046 no 3101 0.0697161724815815 4498 5230760 SGTC_264 promethazine 12.5 mM -1.48212164453692 0.0776772574600391 no 3102 0.0691539652720927 4355 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3309 9129340 25.759 µM -1.48239477039986 0.0776394110027955 no 3103 0.0691176423320389 4473 17158987 SGTC_563 tetrahydrosecaminediol 614 µM -1.489620454963 0.0766432404191932 no 3104 0.0681620302675313 4532 334274 A psychoactive constituent of the cannabis plant. SGTC_1695 st026914 34.495 µM -1.49027653716716 0.0765532731056703 no 3105 0.0680757695490426 4477 3289191 SGTC_3270 9137563 49.47 µM -1.49340931144897 0.0761247889196345 no 3106 0.0676650385258196 4489 17015724 SGTC_1453 4237-0541 195 µM -1.49355481129486 0.0761049326796725 no 3107 0.0676460089924251 4495 739892 SGTC_2839 9003951 25.97 µM -1.49373077549221 0.0760809242632375 no 3108 0.0676230006325798 4535 2990634 SGTC_2046 4110841 106 µM -1.49749214885143 0.075569103263262 no 3109 0.0671326234782093 4495 44119630 YMR134W ERG29 SGTC_3336 9143619 71.43 µM -1.49761478461833 0.0755524601300248 no 3110 0.0671166816399207 4498 45595730 SGTC_1375 2910-0797 186 µM -1.49989906273734 0.0752429666835131 no 3111 0.0668202754101345 4487 742508 SGTC_1855 st056195 39.6 µM -1.5089123281877 0.0740311980621054 no 3112 0.0656605944585133 4419 4028379 SGTC_2678 equilin 100 µM -1.51301543419241 0.0734845282352095 no 3113 0.0651378692198775 4499 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1332 1480-0653 17.5 µM -1.51675890706166 0.0729884714138044 no 3114 0.0646637827707336 4502 5749438 SGTC_1657 st012939 43.4 µM -1.51697723705675 0.0729596192608647 no 3115 0.0646362156233226 4499 24207257 SGTC_435 c-PAF 6.7 µM -1.51711977180748 0.0729407881057766 no 3116 0.0646182235872381 4431 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1410 3909-8106 77.9 µM -1.51834777193515 0.0727787034176603 no 3117 0.0644633752977312 4554 1039210 SGTC_991 3996-0057 64.7 µM -1.52191906160372 0.0723088932601229 no 3118 0.0640146811715106 4535 715343 SGTC_998 3996-0085 177 µM -1.52200046542114 0.0722982115828997 no 3119 0.0640044820368932 4535 715391 SGTC_2229 7354935 190 µM -1.52272279270857 0.0722034819266946 no 3120 0.0639140365446607 4483 318112 SGTC_814 3342-0569 96 µM -1.52578793785383 0.0718025613267808 no 3121 0.0635313428262187 4547 4346283 SGTC_357 1325-0123 420 µM -1.52609976889807 0.0717618697419727 no 3122 0.0634925098158883 4508 1098503 SGTC_3174 9107204 49.47 µM -1.53019151814214 0.0712295650015213 no 3123 0.062984665117002 4518 3938802 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.5315389101218 0.0710549448556014 no 3124 0.0628181287755536 4480 756377 SGTC_2464 5717415 7.67 µM -1.5360323130429 0.0704749818292927 no 3125 0.0622652277346089 4477 5285744 SGTC_2933 9026794 32.47 µM -1.54030907007913 0.0699263680037253 no 3126 0.0617425169755208 4456 17586027 SGTC_1181 1222-0449 220 µM -1.54761131920365 0.0689972537310977 no 3127 0.0608579522584174 4554 658318 SGTC_1041 0206-0046 107 µM -1.55003986955498 0.0686903704900146 no 3128 0.0605659734444481 4528 50494 SGTC_2941 9056145 11.23 µM -1.55013899096972 0.0686778674277557 no 3129 0.0605540796313561 4468 2119517 SGTC_3258 9138477 49.47 µM -1.55344230979712 0.0682621936213545 no 3130 0.060158750784188 4546 4970355 SGTC_2716 st080858 38.6235 µM -1.55948877243503 0.0675063687355963 no 3131 0.0594403699518544 4517 5296050 SGTC_1043 0916-0009 19.3 µM -1.56160843245357 0.0672429416588247 no 3132 0.0591901308792339 4534 3101130 SGTC_204 PMA1.184 62.41 µM -1.56735166190122 0.0665331783654291 no 3133 0.0585162579910348 4500 2252213 YGL008C PMA1 SGTC_2278 7948257 134.34 µM -1.5685385335875 0.0663872273348039 no 3134 0.0583777522290949 4529 1247028 SGTC_842 0271-0008 11.1 µM -1.56995580502603 0.0662132686726895 no 3135 0.0582126966879999 4544 1221709 SGTC_2237 6667747 47.222 µM -1.57026526769541 0.0661753316242702 no 3136 0.0581767054545545 4522 729940 YDL015C TSC13 SGTC_1779 st039427 55 µM -1.57324982021232 0.0658103188246111 no 3137 0.0578304917498471 4524 1124498 SGTC_3064 1327-0027 10 µM -1.57340936570321 0.0657908503307556 no 3138 0.0578120298792717 4501 16000455 YPR107C YTH1 SGTC_2069 5228469 200 µM -1.57576964401482 0.0655033592740423 no 3139 0.0575394503081787 4530 2835210 SGTC_596 1155-0152 116 µM -1.58769830139897 0.0640652825700546 no 3140 0.0561772886675185 4547 280313 SGTC_2643 anethole 100 µM -1.58917697334656 0.0638887424302045 no 3141 0.0560102217939411 4551 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1379 2144-0755 36.5 µM -1.59100677228244 0.0636708049280754 no 3142 0.0558040258364247 4582 5392327 SGTC_1280 0880-0253 10.1 µM -1.59163510217504 0.0635961014910681 no 3143 0.0557333590511369 4520 6836607 SGTC_3170 9103054 49.47 µM -1.5990135654839 0.062723955349061 no 3144 0.0549087942126049 4515 16432970 SGTC_3278 9139605 49.47 µM -1.60018008332071 0.0625869284695401 no 3145 0.0547793195848744 4527 7958859 SGTC_2955 9076254 12.21 µM -1.6020250398345 0.0623706842283853 no 3146 0.0545750362414259 4475 16459619 SGTC_2207 7258803 200 µM -1.60537970829724 0.0619789825471778 no 3147 0.0542051336231197 4574 3666799 SGTC_2928 9011484 9.79 µM -1.61533212010231 0.0608281975235388 no 3148 0.0531193956978171 4535 2994751 SGTC_1815 st051655 58.2 µM -1.61902046165645 0.0604059874471164 no 3149 0.0527214303255451 4513 5984156 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.6198714620855 0.0603088984958089 no 3150 0.0526299456446093 4529 16623 A steroid. SGTC_891 0929-0073 133 µM -1.62078842840495 0.0602044203760382 no 3151 0.0525315105197286 4570 5603632 SGTC_3339 9145883 14.936 µM -1.62245781007425 0.0600145767289743 no 3152 0.0523526798346926 4472 2030670 SGTC_2030 5175110 200 µM -1.62428266921301 0.0598075886919441 no 3153 0.0521577471475131 4553 2831986 SGTC_1466 k213-0079 57.5 µM -1.62763510593089 0.0594287901800818 no 3154 0.0518011403299874 4540 3657981 SGTC_1635 st007035 42.4 µM -1.6282632096943 0.0593580291300229 no 3155 0.0517345434556297 4507 3716403 SGTC_727 3032-0951 202 µM -1.62943924989153 0.0592257161842327 no 3156 0.051610032749296 4587 3652836 SGTC_426 0988-0037 14.6 µM -1.64017737434878 0.0580282725383535 no 3157 0.0504841461244049 4563 5383008 SGTC_3250 9135583 49.47 µM -1.64393211009628 0.0576140880371161 no 3158 0.0500951132837819 4575 7699353 SGTC_2073 5212005 126 µM -1.647887621498 0.0571802745105983 no 3159 0.0496878670030793 4502 691789 SGTC_2053 5265679 138 µM -1.65307566426657 0.0566151875797216 no 3160 0.0491577327072798 4487 764595 SGTC_173 1273-0061 2.693 µM -1.65398650290379 0.0565164336890021 no 3161 0.0490651275569679 4513 2847414 YPL266W DIM1 SGTC_2077 5212015 200 µM -1.65915479789779 0.0559586507485835 no 3162 0.0485423017346407 4493 780900 SGTC_2582 agaric acid 100 µM -1.65977245539097 0.0558922821944247 no 3163 0.0484801184756001 4200 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_722 3534-0461 190 µM -1.66382211646251 0.0554586749481185 no 3164 0.0480739914298092 4587 658262 SGTC_3040 9091894 49.47 µM -1.66715542391278 0.0551037658698641 no 3165 0.0477417518998499 4485 25236966 SGTC_1251 0490-5699 265 µM -1.67085028271548 0.0547124605691991 no 3166 0.0473756268871336 4581 3883818 SGTC_263 alizarin 107.927 µM -1.6718949547516 0.0546022235102581 no 3167 0.0472725189258462 4608 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_71 0417-1750 47.813 µM -1.67346002197895 0.0544374014688222 no 3168 0.0471183851778357 4532 6811472 SGTC_3189 9110682 49.47 µM -1.68095405176914 0.053653629216019 no 3169 0.0463859198970161 4574 17122418 SGTC_492 tmb-8 126 µM -1.68274650606035 0.0534674942240566 no 3170 0.046212087325487 4610 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2644 guaiazulene 100 µM -1.68560010108227 0.0531722226107033 no 3171 0.0459364248723946 4614 3515 A coloring agent. SGTC_875 0709-0210 25.7 µM -1.69251589833448 0.0524619828174249 no 3172 0.0452738257093154 4565 6251364 SGTC_1524 corynanthine 62.1 µM -1.69615337821166 0.0520914540018142 no 3173 0.0449284185323004 4636 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1832 st054113 55 µM -1.69777226184003 0.0519272176778035 no 3174 0.0447753765407725 4604 1251267 SGTC_352 k048-0007 5.11 µM -1.70446922458098 0.0512521757616434 no 3175 0.0441467304185191 4514 6811911 SGTC_1372 2752-0194 270 µM -1.70917131968821 0.0507823986459046 no 3176 0.0437096098906623 4527 823334 SGTC_1475 4092-1048 11.7 µM -1.71036100095425 0.0506640850604735 no 3177 0.0435995689895147 4600 2881759 SGTC_747 3448-8087 38.7 µM -1.71373393737011 0.0503298404232032 no 3178 0.0432888005405347 4628 5168703 SGTC_3157 9099274 49.47 µM -1.71695324887143 0.0500124607821744 no 3179 0.0429938571974466 4597 17217662 SGTC_2958 9077254 16.72 µM -1.71735737345672 0.0499727326731881 no 3180 0.0429569475299474 4593 16457351 SGTC_543 3844-1095 191 µM -1.71768292631468 0.0499407469889196 no 3181 0.0429272326306078 4608 4230703 SGTC_385 1494-0393 12.4 µM -1.71918352495698 0.0497935236610548 no 3182 0.0427904798633635 4555 3090647 SGTC_161 4065-0411 162.148 µM -1.72001786608691 0.0497118165659927 no 3183 0.0427145970216116 4582 1906281 YLR208W SEC13 SGTC_2354 9060492 162 µM -1.72036700343759 0.049677657279527 no 3184 0.0426828754839981 4592 6471895 SGTC_2626 ethyl orsellinate 100 µM -1.72199985386691 0.049518149197437 no 3185 0.0425347724831357 4531 75653 A natural product. SGTC_236 1509-0011 5.31 µM -1.72215364615351 0.0495031467944772 no 3186 0.0425208446362952 4610 3107280 SGTC_3136 9095672 49.47 µM -1.72231364559671 0.0494875427354036 no 3187 0.0425063585671549 4467 17217380 SGTC_1121 fusaric acid 630.51 nM -1.72333746538388 0.0493877869003637 no 3188 0.0424137581722339 4571 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3330 9141424 71.43 µM -1.72706789402258 0.0490256701584423 no 3189 0.0420777354134013 4605 27261020 SGTC_1830 st055982 50.3 µM -1.72840945273056 0.048895963331184 no 3190 0.0419574209810129 4591 455313 An antimicrobial agent. SGTC_3210 9128157 49.47 µM -1.73404261086085 0.0483543191852166 no 3191 0.0414552614643829 4544 17590849 SGTC_2828 7998861 71.43 µM -1.7426557419242 0.0475354323496999 no 3192 0.0406968834412714 4617 2988188 SGTC_2488 5268135 45.7 µM -1.74605648185034 0.0472151844706069 no 3193 0.0404005688670116 4613 1270356 YLR208W SEC13 SGTC_302 1094-0063 18.9 µM -1.75623938620755 0.0462665914597116 no 3194 0.0395237710719968 4616 5440289 SGTC_1096 rimcazole 32.2 µM -1.75744010531107 0.0461557537167571 no 3195 0.0394214112210395 4584 18528119 A dopamine reuptake inhibitor. SGTC_1952 st077036 64.1 µM -1.75771334193212 0.0461305611988347 no 3196 0.0393981482779975 4623 2937007 SGTC_2995 9067767 71.4286 µM -1.75808594418883 0.0460962249325454 no 3197 0.0393664434993291 4596 11673567 SGTC_2583 asiatic acid 100 µM -1.76079001044536 0.0458476528775942 no 3198 0.0391369756230042 4586 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_112 phenothiazine 287.218 µM -1.76476219814085 0.0454844629625135 no 3199 0.0388018701476695 4579 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_3011 9081274 71.4286 µM -1.76718118292628 0.0452644232518619 no 3200 0.0385989449963284 4620 6625322 SGTC_892 0929-0076 29 µM -1.7700605647259 0.0450036213795793 no 3201 0.0383585260042727 4608 5751038 SGTC_2499 avocadenofuran 51.48 µM -1.77009572719311 0.0450004440073603 no 3202 0.0383555976154355 4579 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_3352 9151559 45.5865 µM -1.79042185774359 0.0431937268513338 no 3203 0.0366930595278357 4618 17159339 SGTC_1322 1348-1070 12 µM -1.7974246325207 0.0425850155055531 no 3204 0.0361341165611112 4632 6758089 SGTC_564 3555-0129 330 µM -1.80498959199485 0.041935250135805 no 3205 0.0355381553654241 4571 563260 SGTC_2373 9071805 200 µM -1.81320367289306 0.0412388442654332 no 3206 0.0349002067838895 4633 10149009 SGTC_2746 daunorubicin 9.88 µM -1.81349645555371 0.0412141956785562 no 3207 0.0348776423982083 4662 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_127 0180-0333 59.125 µM -1.81583813273278 0.0410174856628636 no 3208 0.0346976029486146 4554 771601 SGTC_502 l-744,832 89.3 µM -1.81650400863005 0.0409616887506507 no 3209 0.0346465467916947 4639 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1482 3346-2049 8.48 µM -1.82273392760051 0.0404426313295805 no 3210 0.0341718495500279 4657 3826804 SGTC_1996 st072960 66.8 µM -1.82409553499704 0.0403299005880133 no 3211 0.0340688152239845 4655 1719405 SGTC_102 gallobenzophenone 83.616 µM -1.82448255734293 0.0402979046970567 no 3212 0.0340395754866417 4616 70837 SGTC_196 k015-0023 18.111 µM -1.82550942962553 0.040213111072801 no 3213 0.0339620947594853 4598 5211998 SGTC_3269 9137823 49.47 µM -1.82909216824682 0.0399184019742378 no 3214 0.0336929010102148 4585 17682936 SGTC_1939 st074455 53.6 µM -1.82983597002259 0.039857438875546 no 3215 0.0336372351687483 4582 1644229 SGTC_3069 9117009 49.47 µM -1.83218266033613 0.0396655965302684 no 3216 0.0334621056709473 4653 41904981 SGTC_2966 9084041 48.03 µM -1.84538278347073 0.0386004300457793 no 3217 0.0324909378936245 4587 17741380 SGTC_208 k072-0098 12.366 µM -1.84828349587587 0.0383695125792664 no 3218 0.032280671002934 4654 5948901 SGTC_3020 9089140 49.47 µM -1.85337856387761 0.0379666357103718 no 3219 0.0319140587961352 4654 17217859 SGTC_1026 k007-1105 30.6 µM -1.85348100887009 0.0379585707183152 no 3220 0.0319067228493785 4606 7066794 SGTC_2067 5224629 34.075 µM -1.85734778215448 0.0376551792341979 no 3221 0.0316308452296614 4620 2835000 SGTC_2182 6325192 200 µM -1.86472094013327 0.0370821596528424 no 3222 0.0311102650162387 4664 736248 SGTC_407 eburnamonine 100 µM -1.8653498995156 0.037033610521954 no 3223 0.0310661875082829 4529 3195 SGTC_3341 9147222 25.867 µM -1.86554834707912 0.0370183032181654 no 3224 0.0310522910201396 4641 1939759 SGTC_3177 9107506 49.47 µM -1.86627761724506 0.036962095195167 no 3225 0.0310012673240186 4635 8897194 SGTC_3068 9116768 49.47 µM -1.86874293914574 0.0367725985018276 no 3226 0.0308292934717367 4605 41904888 SGTC_276 colchicine 750 µM -1.87109843749891 0.0365922863130299 no 3227 0.0306657190684741 4662 2833 A microtubule depolymerizer. SGTC_2161 5662504 8.5105 µM -1.89327515875922 0.0349298884431629 no 3228 0.0291606434474852 4662 2859334 SGTC_2075 5212009 200 µM -1.89531141231823 0.0347804062946074 no 3229 0.0290255785620412 4616 780898 SGTC_571 k831-0106 44.2 µM -1.89558113801177 0.0347606450829596 no 3230 0.0290077266846917 4561 4783639 SGTC_2598 perillyl alcohol 100 µM -1.89828256382249 0.0345632356493558 no 3231 0.0288294347973086 4641 10819 An apoptosis inducer. SGTC_2493 resveratrol 26.09 µM -1.90265307903512 0.0342458066886741 no 3232 0.0285429141061176 4640 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.91322766500706 0.0334876825856304 no 3233 0.0278594566649767 4632 6728940 SGTC_2940 9060638 45.86 µM -1.91649429642484 0.0332563005690343 no 3234 0.0276511042497045 4626 4027022 SGTC_252 miconazole 1.30953 nM -1.92015859536915 0.0329983195994225 no 3235 0.0274189348905519 4593 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2380 9035439 200 µM -1.92667958574798 0.0325432960578878 no 3236 0.0270097867497742 4691 6462575 SGTC_3129 9127257 49.47 µM -1.93101212444046 0.0322438500378344 no 3237 0.0267407765273506 4617 837894 SGTC_1374 2889-5571 141 µM -1.93245996057197 0.032144290362674 no 3238 0.0266513797142309 4664 2853281 SGTC_2205 7238770 200 µM -1.93520843208149 0.0319559913301754 no 3239 0.0264823617171074 4690 279867 SGTC_1177 0983-0204 23.6 µM -1.93837635626621 0.0317400864522004 no 3240 0.0262886614306653 4697 766818 SGTC_134 0269-0018 6.916 µM -1.94955821188508 0.0309876186630933 no 3241 0.025614399097605 4632 4378915 SGTC_1190 1486-1332 13 µM -1.95054884629648 0.0309216731157953 no 3242 0.0255553686863729 4685 4150046 SGTC_3325 9138760 55.175 µM -1.96119847026 0.0302200470276877 no 3243 0.0249279376285617 4627 43844959 SGTC_1776 st049249 45.9 µM -1.96651066128282 0.0298750287960502 no 3244 0.0246198260149685 4692 1822314 SGTC_2428 5615643 7.78 µM -1.9763031996921 0.029247582361391 no 3245 0.0240602237194939 4678 2253075 SGTC_1462 k081-0014 26.5 µM -1.98166278542898 0.0289088327333114 no 3246 0.0237584974909887 4121 3270634 SGTC_1700 st030840 7.9285 µM -1.98536979456427 0.0286764462395936 no 3247 0.0235516720043283 4711 5499307 SGTC_1684 st024538 14.6195 µM -1.985862952618 0.0286456483503903 no 3248 0.0235242716752484 4679 6732859 SGTC_2397 5161689 200 µM -1.98768446716912 0.0285321324888249 no 3249 0.0234232989339747 4661 2259942 SGTC_778 3456-2434 196 µM -1.99160818237538 0.0282888794294896 no 3250 0.023207032452776 4601 5539063 SGTC_1058 3448-5425 97.3 µM -2.00057037855373 0.0277397315854808 no 3251 0.0227193542187485 4654 7279705 SGTC_2444 5485484 36.41 µM -2.00293680032226 0.027596223502225 no 3252 0.022592036237962 4704 6790631 SGTC_3133 9127736 49.47 µM -2.00362946741315 0.0275543350187549 no 3253 0.0225548834295354 4673 27243420 SGTC_1731 st035964 63 µM -2.00523006569287 0.0274577428529423 no 3254 0.0224692286344747 4587 6739575 SGTC_1834 st055981 52.8 µM -2.00542289440488 0.0274461251933676 no 3255 0.022458928091416 4652 471719 YDL150W RPC53 SGTC_42 0133-0086 60.653 µM -2.01364739247388 0.026954412933075 no 3256 0.0220232834657851 4600 162923 Model of phenazepam hydroxylation. SGTC_1746 st038117 42 µM -2.01392847665029 0.0269377387521552 no 3257 0.0220085216366178 4684 2898218 SGTC_2004 4023728 41.89 µM -2.01724954771027 0.0267413806997184 no 3258 0.0218347388859821 4635 360084 YDR527W RBA50 SGTC_108 0509-0257 621.132 µM -2.0237880754259 0.0263582832613757 no 3259 0.0214959808403017 4674 536624 SGTC_2820 7989630 71.43 µM -2.02601300396564 0.0262289735266643 no 3260 0.0213817260353299 4712 2984098 SGTC_1354 1498-1681 81 µM -2.03500224606609 0.0257119194483369 no 3261 0.0209253234908457 4716 5754243 SGTC_1994 st072947 40.9 µM -2.04822967787574 0.0249666217379972 no 3262 0.020268749879286 4711 5286565 YDL195W SEC31 SGTC_950 1165-0508 94.1 µM -2.06292123178824 0.024160145772233 no 3263 0.0195600562672598 4676 6148369 SGTC_1189 1431-2119 7.28 µM -2.06701415404507 0.023939406460397 no 3264 0.0193664101334613 4702 3107275 SGTC_2078 5212016 200 µM -2.06790372053515 0.0238916552847115 no 3265 0.0193245387508784 4638 1899708 SGTC_2336 9001819 198.65 µM -2.07158564195368 0.023694863431387 no 3266 0.0191520500351224 4668 2989602 SGTC_3114 9122766 49.47 µM -2.07947164372433 0.0232779543088028 no 3267 0.018787010740843 4706 17176985 SGTC_1973 st070275 50.2 µM -2.08009080783845 0.0232454840168692 no 3268 0.018758602283014 4713 17118334 SGTC_751 0833-0568 350 µM -2.08632280321137 0.0229207827543793 no 3269 0.018474696220093 4710 6954252 SGTC_59 0330-0160 1.33 µM -2.09314028767312 0.0225699606568646 no 3270 0.0181683166198667 4661 4293482 SGTC_420 mitomycin C 81.9 mM -2.0962958700818 0.0224091160644611 no 3271 0.0180279764424513 4689 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_737 1950-0117 57.9 µM -2.11192708465844 0.0216265567498413 no 3272 0.0173463519342183 4701 5393513 SGTC_2151 5563267 85.4165 µM -2.11568306252278 0.0214419975979651 no 3273 0.0171858860263877 4738 5310824 SGTC_1738 st035555 74 µM -2.13002356753896 0.020749541456115 no 3274 0.0165848338510812 4682 5331140 SGTC_176 1486-1328 72.834 µM -2.13783895725919 0.0203801993198496 no 3275 0.0162649079837431 4712 22310231 SGTC_2502 avocadyne acetate 18.59 µM -2.14597887649961 0.0200014595325339 no 3276 0.0159373320112512 4695 3952079 SGTC_1564 D-Arginine 115 µM -2.15264832745701 0.0196956049592271 no 3277 0.0156731636806943 4693 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_874 0599-0792 117 µM -2.15528185644539 0.0195759321046801 no 3278 0.0155698923548429 4709 765305 SGTC_3155 9099265 49.47 µM -2.16092077405445 0.0193217638156495 no 3279 0.0153507299385648 4694 25236499 SGTC_1165 k072-0275 30.3 µM -2.16524858096811 0.0191285994939332 no 3280 0.0151843268843172 4713 6153523 YGL055W OLE1 SGTC_1813 st051246 8.6015 µM -2.16535308578221 0.0191239554738504 no 3281 0.0151803279385934 4708 5291959 SGTC_53 0973-0023 39.979 µM -2.16945157488652 0.018942579908984 no 3282 0.0150242085076006 4660 674768 SGTC_1969 st069479 40.1 µM -2.17978014352979 0.0184919754890615 no 3283 0.0146368812495989 4720 3895485 SGTC_2522 biochanin a 4.94 µM -2.18386757673571 0.0183161909473641 no 3284 0.0144859900748175 4710 5280373 A possible chelator. SGTC_1734 st037168 69.4 µM -2.18935761276665 0.0180823276708408 no 3285 0.0142854289638333 4705 708907 SGTC_1411 3909-8223 150 µM -2.19415146973219 0.0178802064743415 no 3286 0.0141122610536391 4758 X1411 SGTC_3073 9114972 49.47 µM -2.2117400182919 0.0171550516787304 no 3287 0.0134923168539692 4724 41905075 SGTC_47 0149-0135 24.25 µM -2.2228311670886 0.0167108182139603 no 3288 0.0131135933098635 4711 5239155 SGTC_2745 rifampicin 24.3 µM -2.22507536627335 0.016622138621117 no 3289 0.0130380895650933 4784 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2109 5483026 200 µM -2.23612802047254 0.0161912455339915 no 3290 0.0126716932328946 4735 759335 SGTC_384 k007-0144 5.16 µM -2.23923881931679 0.0160717090170555 no 3291 0.0125701906369452 4714 6824886 SGTC_507 nimesulide 162 µM -2.26477716620473 0.0151186464011243 no 3292 0.0117631786620168 4750 4495 A COX2 inhibitor. SGTC_2148 5546263 113.568 µM -2.26658959212184 0.015052893749228 no 3293 0.0117076542401398 4749 792097 SGTC_3131 9127911 49.47 µM -2.28943945421261 0.0142447820938746 no 3294 0.0110269159853071 4708 45595681 SGTC_104 0074-0074 590.992 µM -2.30637190437427 0.0136703135587416 no 3295 0.0105449302437816 4707 3943124 SGTC_1570 verbenone 133 µM -2.3085289202876 0.0135985876198394 no 3296 0.0104848681077833 4733 29025 A natural terpanoid with antifungal properties. SGTC_2557 derrustone 83.84 µM -2.32460905457364 0.0130740480582221 no 3297 0.0100464370983384 4732 629853 An antioxidant. SGTC_1186 1319-0216 26 µM -2.33020439946887 0.0128956734121678 no 3298 0.00989767528564645 4762 4565136 SGTC_1463 k081-0032 34.1 µM -2.34185907985959 0.0125308793437013 no 3299 0.00959397914140829 4295 977755 SGTC_233 rapamycin 362 pM -2.34411818457305 0.0124612120962783 no 3300 0.0095360634460154 4750 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_219 mitoxanthrone 164.414 µM -2.3480302547544 0.0123413631371036 no 3301 0.00943649411577432 4738 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2910 7948405 25.97 µM -2.34941444591326 0.0122991973018273 no 3302 0.00940148233021464 4742 2971328 SGTC_975 1335-0046 28.5 µM -2.37314917527005 0.0115953605672814 no 3303 0.00881856953468029 4750 16486740 SGTC_1128 3448-9350 235 µM -2.39607678928914 0.0109489366995174 no 3304 0.00828580908469418 4698 619386 SGTC_2420 aureobasidin a 50 nM -2.41464858297615 0.0104485352110085 no 3305 0.00787519875711661 4745 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1750 st081859 2.357 µM -2.41485862372696 0.0104429917564576 no 3306 0.00787065912690936 4686 5291695 SGTC_3190 9110366 49.47 µM -2.43198696105271 0.00999947732363596 no 3307 0.00750812393803228 4739 17123768 SGTC_2948 9070189 9.45 µM -2.44090167372506 0.00977521638368923 no 3308 0.00732532156207388 4703 6473636 YDL196W YDL196W SGTC_3144 9087057 49.47 µM -2.46942936288304 0.0090868267085241 no 3309 0.00676643667360923 4707 17249618 SGTC_2831 7999036 19.48 µM -2.474566502943 0.00896748041769837 no 3310 0.00666989912944179 4720 2988270 SGTC_2351 9026858 72.31 µM -2.51057996180688 0.00816870445851326 no 3311 0.00602665103761275 4715 1409300 SGTC_2825 7998094 58.44 µM -2.51573064382283 0.00805972917768133 no 3312 0.00593929632638819 4727 2987815 SGTC_1327 1436-0082 2.18 µM -2.52703854220443 0.00782495502542494 no 3313 0.0057514439149082 4776 15992205 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -2.53941857724889 0.00757484017201787 no 3314 0.00555184439269548 4756 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_792 4534-1957 155 µM -2.53947500758532 0.00757371641381286 no 3315 0.00555094885113159 4751 1717904 SGTC_907 3448-6986 75.5 µM -2.5826056225385 0.00675658205129794 no 3316 0.00490286709143668 4758 590582 SGTC_910 3454-3003 490 µM -2.58772973707109 0.00666487679383836 no 3317 0.00483053739869771 4705 820824 SGTC_2532 xanthone 78.9 µM -2.60182767997516 0.00641822186320758 no 3318 0.00463642160786345 4769 7020 An insecticide. SGTC_3139 9095020 49.47 µM -2.62021937553527 0.00610860377969853 no 3319 0.00439366094370113 4734 25236292 SGTC_2340 7987427 183.45 µM -2.63097803714775 0.0059336859500562 no 3320 0.004256976895013 4748 2239331 SGTC_1191 1487-1166 10.6 µM -2.63549781600332 0.0058615366945812 no 3321 0.00420069832212601 4768 3955771 SGTC_3126 9127922 49.47 µM -2.63873354893974 0.00581036371684429 no 3322 0.00416081791120935 4725 45595682 SGTC_2409 alverine citrate 63.97 µM -2.6586907593086 0.00550341342356561 no 3323 0.00392224641576105 4738 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2411 st077133 39.94 µM -2.65989948528816 0.00548529415857883 no 3324 0.00390819871497707 4738 1403142 YNL221C POP1 SGTC_3335 9143315 29.6265 µM -2.69736961224376 0.00494926199332519 no 3325 0.00349448243890556 4770 4899691 SGTC_457 grayanotoxin iii 135 µM -2.71163185390018 0.00475782692529289 no 3326 0.00334764534676879 4646 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1127 asiatic acid 681.4 nM -2.72689104364425 0.0045603478552304 no 3327 0.00319670732578346 4752 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3071 9117417 49.47 µM -2.73834506497343 0.00441695605779071 no 3328 0.0030874624140225 4762 45595590 YGL055W OLE1 SGTC_1950 st077106 7.18 µM -2.74932053752077 0.00428334824647982 no 3329 0.00298594774524802 4750 13831864 SGTC_1732 st034308 51.822 µM -2.75873836061415 0.00417159506246152 no 3330 0.00290124856318441 4738 830119 SGTC_365 0121-0052 13.6 µM -2.79693704890257 0.00374459696987795 no 3331 0.00257947919544348 4762 3101739 SGTC_3125 9127534 49.47 µM -2.80590859882726 0.00365017716042611 no 3332 0.00250874612339857 4768 1639235 SGTC_11 0438-0307 1.3 µM -2.88339275828257 0.00291949974414508 no 3333 0.00196708289532482 4783 4011476 SGTC_2384 9036245 200 µM -2.90492038646066 0.00274138451514935 no 3334 0.00183673262944017 4785 6462766 SGTC_3076 9116187 49.47 µM -2.92616156873487 0.00257531263569963 no 3335 0.00171586330446246 4781 27241210 SGTC_3299 9121982 43.1275 µM -2.96057448580286 0.00232547451922859 no 3336 0.00153532929958328 4785 17594604 YPL160W CDC60 SGTC_39 0986-0283 58.349 µM -2.97031345662983 0.00225886861820086 no 3337 0.0014874801176681 4790 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_52 0329-0193 875 nM -2.99839681168618 0.00207636810518242 no 3338 0.00135702022977355 4780 3739292 SGTC_2531 methyl deoxycholate 70.07 µM -3.03869100480457 0.00183783526756387 no 3339 0.00118804213324734 4758 16667744 Haematoxylin. SGTC_1562 morin hydrate 59.1 µM -3.07641128215632 0.00163740566509529 no 3340 0.00104754319759461 4790 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2387 9077560 195.08 µM -3.08004927941969 0.0016191680579879 no 3341 0.00103483173800188 4791 5303272 SGTC_1049 3226-0134 66 µM -3.1468139534459 0.0013157092478064 no 3342 0.000825299758513839 4788 5702385 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -3.15579613458856 0.00127911408567102 no 3343 0.000800303459637491 4769 6708760 SGTC_2592 piperlongumine 83.33 µM -3.3171842660198 0.000761624498163599 yes 3344 0.000454648123146863 4781 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_54 0159-0055 9 µM -3.31874506914979 0.000757733428271325 yes 3345 0.000452114694682219 4787 3319099 SGTC_889 0919-1524 82.7 µM -3.35833206097346 0.000664961515061627 yes 3346 0.000392071765240359 4805 3905452 SGTC_3194 9111903 49.47 µM -3.38358655112261 0.000611377946061207 yes 3347 0.000357728265340152 4796 17087251 SGTC_3310 9130229 44.1445 µM -3.41265586164212 0.000554650914429129 yes 3348 0.000321665633768287 4798 7761258 SGTC_1047 2043-3044 82 µM -3.41820831245973 0.000544385423622861 yes 3349 0.000315174211240655 4785 669592 SGTC_1082 camptothecin 424.86 nM -3.50548520269729 0.000404462215182661 yes 3350 0.000227887917973455 4754 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_790 1575-0012 79.1 µM -3.50749111895911 0.000401679134419044 yes 3351 0.000226176726367694 4806 378741 YLR208W SEC13 SGTC_1725 st036284 20.55 µM -3.51962232267818 0.000385223082448562 yes 3352 0.00021608085212954 4798 707914 SGTC_887 0885-0007 9.62 µM -3.69044456797558 0.000210909355424485 yes 3353 0.000111931234629333 4796 5719458 SGTC_48 0382-0018 55 µM -3.75892155334498 0.000164502868656877 yes 3354 8.53236637709203e-05 4797 762596 SGTC_2691 st077356 60.2 µM -3.7693027941917 0.000158365150887257 yes 3355 8.18520968252803e-05 4799 2839272 SGTC_1060 3448-7350 82 µM -4.85913817438464 1.74080653166457e-06 yes 3356 5.89489167131039e-07 4808 570178