SGTCid condition conc unit YLR283W|YLR283W.score YLR283W|YLR283W.strain.pval YLR283W|YLR283W.strain.significant YLR283W|YLR283W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2259 7964009 200 µM 5.27617696520065 1.13664152764997e-08 yes 1 6.59533573382524e-08 17 313134
SGTC_2787 5284540 71.43 µM 4.96217735357891 7.26927514274648e-08 yes 2 3.48536499348035e-07 9 736958
SGTC_2372 9071633 200 µM 4.63775334048677 4.42076001396517e-07 yes 3 1.76108380333568e-06 6 21321366
SGTC_2237 6667747 47.222 µM 4.62607210017269 4.70767592904725e-07 yes 4 1.86332807332065e-06 9 729940 YDL015C TSC13
SGTC_1073 triclabendazole 3.09 µM 4.54948501152781 7.08401413169008e-07 yes 5 2.68886820581556e-06 18 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_945 3381-0768 11.3 µM 4.28213151017615 2.80766672091424e-06 yes 6 9.25557594264076e-06 27 1126236 YIL048W NEO1
SGTC_73 0327-0325 16.231 µM 4.08996040536284 7.20557706297874e-06 yes 7 2.15723417623373e-05 46 53298
SGTC_173 1273-0061 2.693 µM 4.00191390571743 1.09516293034742e-05 yes 8 3.14160815067667e-05 184 2847414 YPL266W DIM1
SGTC_3336 9143619 71.43 µM 3.98443460996228 1.18889831329847e-05 yes 9 3.38204895771073e-05 20 45595730
SGTC_6 0844-0013 19.835 µM 3.866176816843 2.05461329546067e-05 yes 10 5.52773993576104e-05 96 1584900
SGTC_3208 9114115 49.47 µM 3.82696383297834 2.45517695985083e-05 yes 11 6.48667838412649e-05 42 650895
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 3.74289264368628 3.57709824919849e-05 yes 12 9.09569815086038e-05 101 16725076
SGTC_2278 7948257 134.34 µM 3.711280640846 4.11288129008961e-05 yes 13 0.000103106662242258 27 1247028
SGTC_1521 st012942 49.4 µM 3.58378613713372 7.14401712997539e-05 yes 14 0.000169324699372527 43 24207259
SGTC_1175 0741-0056 27.6 µM 3.55486714444925 8.07781832799204e-05 yes 15 0.000189085061590509 34 765927
SGTC_3215 9129942 49.47 µM 3.51973212058444 9.36691409397741e-05 yes 16 0.000215991427661235 20 17682944
SGTC_2909 7941780 10.49 µM 3.38885858940488 0.000160743282344865 yes 17 0.000350920974107034 41 1243215
SGTC_12 0849-0099 9.267 µM 3.38127493127321 0.000165761215592823 yes 18 0.00036075156465439 32 6071388
SGTC_2004 4023728 41.89 µM 3.36309577855811 0.000178393059004024 yes 19 0.000385368090646676 51 360084 YDR527W RBA50
SGTC_2421 5690543 90.72 µM 3.29834396508424 0.00023107700599577 yes 20 0.000486284584303303 41 3397993
SGTC_2308 7584454 197.62 µM 3.28826922099359 0.0002404748235873 yes 21 0.000504026960869228 53 893577
SGTC_130 0136-0219 337.655 µM 3.20165281833074 0.000337291410928695 yes 22 0.000683207877269673 52 234244
SGTC_1128 3448-9350 235 µM 3.13444670391226 0.000436173842208184 yes 23 0.000860892638312912 57 619386
SGTC_3173 9105693 49.47 µM 3.11147319559335 0.000475725273315851 yes 24 0.000930781866406769 60 17096658
SGTC_2282 7944268 200 µM 3.04702631624489 0.00060509928305696 yes 25 0.00115558737319025 86 2970414
SGTC_861 0443-0273 110 µM 3.04651969579163 0.000606234187324141 yes 26 0.0011575365571262 46 6149169
SGTC_1351 1496-0003 46.5 µM 3.01109928152192 0.000690634125575085 yes 27 0.00130151863479542 55 3891978
SGTC_1851 st056236 18.9 µM 2.99710587211835 0.000726867463928017 yes 28 0.00136278019274908 54 5393171
SGTC_2916 7875993 68.79 µM 2.97053773380767 0.000800524096410664 yes 29 0.00148639441210654 72 1299250
SGTC_2460 5552655 174.22 µM 2.96201363675875 0.000825574142669273 yes 30 0.00152817123608476 83 5401989
SGTC_1163 k060-0048 49.9 µM 2.93585847453529 0.000907008108773289 yes 31 0.00166313019838343 77 6809982
SGTC_219 mitoxanthrone 164.414 µM 2.91751662732127 0.000968450274672914 yes 32 0.00176415418339009 88 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1793 st048256 72.231 µM 2.90744962928253 0.00100377539525803 no 33 0.00182194511717828 23 672022
SGTC_3327 9140648 26.9345 µM 2.87677971112955 0.00111881211037693 no 34 0.00200877977164855 47 8029710
SGTC_1158 4092-0494 91.8 µM 2.86106539073189 0.0011823226580014 no 35 0.00211109978256254 56 1148199
SGTC_807 1315-0151 48 µM 2.86075801176338 0.00118359722937789 no 36 0.00211314751903908 86 4011080
SGTC_2589 lobaric acid 100 µM 2.86003327845 0.00118660737511413 no 37 0.00211798277344099 84 73157 A novel microtubule depolymerizer.
SGTC_1206 3978-0017 132 µM 2.8438054341818 0.00125587148223601 no 38 0.00222891301589322 86 3873677
SGTC_1006 4099-6547 255 µM 2.8297545478452 0.00131881046622266 no 39 0.00232918635381231 92 3146833
SGTC_1674 st016616 23.6 µM 2.82026473602055 0.00136293604801734 no 40 0.00239920222759167 87 625830
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 2.80970883453939 0.00141360044061423 no 41 0.00247931687310761 59 6708784 An antioxidant flavonoid
SGTC_2998 9066762 71.4286 µM 2.74181781006691 0.00178269956111937 no 42 0.00305501105741493 103 4945196
SGTC_2835 9006588 71.43 µM 2.71705517796163 0.00193781144345067 no 43 0.00329328129561002 122 2345538
SGTC_644 1498-1197 63.3 µM 2.69613287460021 0.00207831527183646 no 44 0.00350748388372294 105 6741615
SGTC_2132 5317594 122.667 µM 2.69315103946001 0.00209907543626652 no 45 0.00353900981293701 81 794577
SGTC_774 k060-0086 136 µM 2.69243132707352 0.0021041143247601 no 46 0.00354665710106841 88 5911235
SGTC_2560 caryophyllene 100 µM 2.65573370011527 0.00237605549007185 no 47 0.00395680395696928 95 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1680 diphenhydramine 100 µM 2.64211149149177 0.00248483762004833 no 48 0.00411954646630704 114 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_859 0439-0102 54.6 µM 2.59354179345578 0.0029103254552416 no 49 0.00474964964817999 101 610143
SGTC_1162 k048-0130 20.1 µM 2.59308673901136 0.00291460502369317 no 50 0.00475593888130979 84 6797406
SGTC_1084 voriconazole 435 nM 2.57597296776403 0.00307972827719606 no 51 0.00499792303669266 105 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2119 5528445 120.635 µM 2.55242538791235 0.00332069612279535 no 52 0.00534879096545604 112 791935
SGTC_1755 st041960 45.185 µM 2.52815801850817 0.00358663919785039 no 53 0.0057331365856835 108 2257073
SGTC_2676 harmalol 100 µM 2.50532389382663 0.00385417154369349 no 54 0.00611696522966512 91 5459187 A monoamine oxidase inhibitor
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 2.50357942541294 0.00387532764231374 no 55 0.00614720410114608 70 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2985 9022375 71.43 µM 2.49698043786806 0.00395630158677075 no 56 0.00626279331438418 142 4939335
SGTC_1498 4478-3555 97.6 µM 2.49230209248981 0.00401462256535071 no 57 0.00634590193912038 49 3437919
SGTC_2606 farnesol 9.78 µM 2.48530890247009 0.0041032365265794 no 58 0.00647195308558232 118 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2469 5655019 90.81 µM 2.48485227978185 0.00410908302615982 no 59 0.00648026014895758 119 2788239
SGTC_3335 9143315 29.6265 µM 2.47970130956918 0.00417555317018446 no 60 0.00657462404069288 98 4899691
SGTC_3147 9097027 49.47 µM 2.47787802031226 0.00419931110474111 no 61 0.00660831604373652 114 25236841
SGTC_2348 9022543 33.42 µM 2.46680588553807 0.00434619794449216 no 62 0.00681621185883208 125 3162678 YDL140C RPO21
SGTC_336 4111-0029 111 µM 2.44535667806986 0.00464387406890941 no 63 0.00723544755159903 88 3131175
SGTC_1263 0774-1208 64.8 µM 2.44201326632241 0.00469187852659279 no 64 0.00730280494728806 189 906585
SGTC_960 1222-0186 7.7 µM 2.4215711563041 0.00499513091442974 no 65 0.00772678762793979 142 3126296
SGTC_2786 7743617 45.45 µM 2.38821682908059 0.00552752814654982 no 66 0.00846517487953189 128 583674
SGTC_1281 0884-0031 11.8 µM 2.37379079925551 0.00577300780347081 no 67 0.00880326140413039 161 1548255
SGTC_1490 4089-0339 670 nM 2.35653906336743 0.00607923730871371 no 68 0.00922306371312346 76 742542
SGTC_2321 7390090 138.78 µM 2.3346392758828 0.00648865564436617 no 69 0.00978113647928079 145 649046
SGTC_1700 st030840 7.9285 µM 2.31111803547672 0.00695537774947009 no 70 0.0104131680252488 148 5499307
SGTC_2339 9000433 200 µM 2.30986890519315 0.0069809723847531 no 71 0.0104477065211644 152 2988954
SGTC_584 0986-0246 15.4 µM 2.30451328735518 0.00709165360160295 no 72 0.0105969236682728 141 53315 YDR232W HEM1
SGTC_668 1682-0499 62.6 µM 2.2879986794928 0.00744275992376134 no 73 0.0110687990096405 164 682214
SGTC_3029 9088683 49.47 µM 2.27501173412226 0.00772953546290711 no 74 0.0114526129651269 148 25236615
SGTC_120 rhodamine 6G 52.259 µM 2.27476239917996 0.00773513509221495 no 75 0.011460093490578 204 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_710 3448-4187 58 µM 2.26717077924157 0.00790734763865098 no 76 0.0116898975668214 254 3946412
SGTC_991 3996-0057 64.7 µM 2.24062403611147 0.00853634654538727 no 77 0.0125252192103126 147 715343
SGTC_2275 7947463 200 µM 2.23419841137001 0.0086950400212728 no 78 0.012735010464266 145 1225414
SGTC_2558 carylophyllene oxide 100 µM 2.23352049975983 0.00871193230753448 no 79 0.0127573200049553 154 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3257 9139206 32.98 µM 2.22053706222463 0.00904105423150899 no 80 0.013191166368637 88 4910041
SGTC_2458 5808907 16.39 µM 2.21093613757807 0.00929138628708565 no 81 0.0135201298784187 110 2731747
SGTC_415 dibenzyl ketone 100 µM 2.19537326493935 0.00971006015477972 no 82 0.0140684166398481 151 7593
SGTC_2317 5986382 200 µM 2.19535140372335 0.0097106596749741 no 83 0.0140692001021645 126 877883
SGTC_2297 7971671 152.32 µM 2.19499624710705 0.0097204039925511 no 84 0.0140819334744989 165 909016
SGTC_2600 tangeritin 87.95 µM 2.18080725657498 0.0101167556229066 no 85 0.0145988378120747 164 68077 A bioactive flavone.
SGTC_3126 9127922 49.47 µM 2.17689643537393 0.0102284487206344 no 86 0.014744147730263 214 45595682
SGTC_2286 7945697 125 µM 2.17388567227193 0.0103151673918589 no 87 0.014856861163188 223 1245733
SGTC_2369 9071472 200 µM 2.16819844990873 0.0104807261889111 no 88 0.0150717953562748 178 17296037
SGTC_1102 cgs 12066b 26.1 µM 2.1602315355443 0.010716540131802 no 89 0.0153773750116521 138 6438352 A 5-HT1B full agonist.
SGTC_1650 st011916 45.8 µM 2.15025437969048 0.0110183610157537 no 90 0.0157675494145475 131 242528
SGTC_64 000l-0018 272.079 µM 2.1423058843845 0.0112640783555075 no 91 0.0160844378198482 362 6811119
SGTC_3259 9138485 49.47 µM 2.14091350444746 0.0113076087165079 no 92 0.0161405069536683 188 17646153
SGTC_1352 1496-0991 99 µM 2.12675852732337 0.0117585023893131 no 93 0.0167200759054433 186 3000039
SGTC_1876 myriocin 605 nM 2.11892980241377 0.0120145183907017 no 94 0.0170481999350673 181 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2973 9094665 17.96 µM 2.1175004760842 0.0120617785947135 no 95 0.0171086974682027 236 25237061 YIL048W NEO1
SGTC_899 1083-0020 478 µM 2.1162269804415 0.0121040220041583 no 96 0.0171627537928998 195 767123
SGTC_3085 9117376 49.47 µM 2.10890704652579 0.0123493289090039 no 97 0.0174763029296245 177 16480349
SGTC_323 4013-0906 34.3 µM 2.09564242255113 0.0128048400897533 no 98 0.0180569614998808 149 2910086
SGTC_2422 chlorphenesin carbamate 384.24 µM 2.09341977827798 0.0128825712720414 no 99 0.0181558491915664 250 2724 A muscle relaxant with antifungal properties.
SGTC_1310 1188-0297 994 nM 2.08056495092611 0.0133401876019849 no 100 0.0187368723957994 201 1588352
SGTC_1176 0848-0131 83.3 µM 2.05225846111357 0.0143975978762843 no 101 0.0200722753218337 235 6769040
SGTC_3143 9086658 49.47 µM 2.04872911084566 0.0145343690874142 no 102 0.0202443054834577 282 25236626
SGTC_2507 purpurin 79.67 µM 2.04117622063039 0.014830823990474 no 103 0.0206166572089223 242 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_948 3448-0295 75.3 µM 2.04113408219782 0.0148324924250642 no 104 0.0206187507658586 238 678569
SGTC_1434 4073-0095 163 µM 2.03618625055152 0.015029522978607 no 105 0.0208658281929567 181 24133745
SGTC_2783 7738165 71.43 µM 2.03610727826309 0.0150326859326083 no 106 0.0208697920266293 176 17201110
SGTC_350 k064-0020 19.8 µM 2.02455370125647 0.0155016300812712 no 107 0.0214566062288819 247 2790705
SGTC_24 0417-1663 219 µM 2.01914809224352 0.0157253135779339 no 108 0.0217359147835908 195 4329390
SGTC_1383 3049-0032 20.7 µM 2.01904607432154 0.0157295615500399 no 109 0.0217412154548003 217 712864
SGTC_2531 methyl deoxycholate 70.07 µM 2.01677556414253 0.0158243594516599 no 110 0.0218594700543159 212 16667744 Haematoxylin.
SGTC_1130 3454-2858 15.9 µM 2.01576752318933 0.0158666037816234 no 111 0.0219121455412447 279 715628 YIL048W NEO1
SGTC_3068 9116768 49.47 µM 2.01433171259817 0.0159269417485473 no 112 0.0219873592934262 215 41904888
SGTC_3002 9075603 71.4286 µM 2.00957873500843 0.0161280845529317 no 113 0.0222378968876793 228 20105405
SGTC_1068 loratadine 26.9 µM 2.00006373761788 0.0165372997850152 no 114 0.022746690911917 219 3957 A H1 histamine antagonist.
SGTC_3193 9111931 49.47 µM 1.99771950643189 0.0166394728776252 no 115 0.0228735391085072 220 17087244
SGTC_1003 4049-0218 100 µM 1.96619071744828 0.0180669934182101 no 116 0.0246382921668001 269 295161
SGTC_2610 ononetin 44.17 µM 1.96605343145872 0.0180734307110554 no 117 0.0246462194448401 308 259632
SGTC_1217 1183-1422 255 µM 1.96541277267787 0.0181034968391823 no 118 0.0246832411806139 229 2849664
SGTC_2218 6965428 192.983 µM 1.96231194238167 0.0182496221196338 no 119 0.0248630888342331 188 675684
SGTC_1736 st036774 51 µM 1.94987635255124 0.018845782742883 no 120 0.025595429143403 240 1272247
SGTC_1378 2093-0007 380 nM 1.94357750660789 0.0191540180647587 no 121 0.0259732102411799 253 3618014
SGTC_884 0851-0618 334 µM 1.93964846139 0.0193484490211187 no 122 0.0262112135287423 253 9642473
SGTC_2813 7971799 71.43 µM 1.93281904376688 0.0196903978089172 no 123 0.026629246755095 228 2234054
SGTC_1342 1486-1464 234 µM 1.92511876466853 0.0200820910423351 no 124 0.0271072509584404 235 3253938
SGTC_31 0508-1974 57.237 µM 1.92471514628238 0.0201028030658233 no 125 0.0271325022848455 222 6810525
SGTC_2399 5884133 200 µM 1.91500986302982 0.0206063206356056 no 126 0.0277456228952792 300 722445
SGTC_3127 9126946 49.47 µM 1.91494698043207 0.020609617550987 no 127 0.027749632768999 217 27243249
SGTC_1735 st034310 56.75 µM 1.91455462937198 0.0206301984901329 no 128 0.027774662970654 245 871153
SGTC_142 0335-0849 62.6745 µM 1.9131536807743 0.0207038279456426 no 129 0.0278641906350609 399 3889043 YPR107C YTH1
SGTC_2516 gossypol 71.55 µM 1.91052434611853 0.0208426183799455 no 130 0.0280328673806902 250 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1088 bifonazole 369 nM 1.90790556789138 0.0209816337062888 no 131 0.0282017112620571 220 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_716 1683-5115 658 µM 1.90428329287855 0.0211752114084313 no 132 0.028436649457539 284 723597
SGTC_474 dl-dihydrosphingosine 5 µM 1.89920995606638 0.02144887334402 no 133 0.0287684381141063 267 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_564 3555-0129 330 µM 1.89658213358623 0.021591792745736 no 134 0.0289415552315495 157 563260
SGTC_1235 benzylparaben 21.5 µM 1.88056056552864 0.0224806760510575 no 135 0.0300158601502007 249 7180
SGTC_1988 st071872 53.4 µM 1.88019993045333 0.0225010341543234 no 136 0.0300404175473239 220 16414116
SGTC_1336 1486-0901 104 µM 1.87840637151032 0.0226025128711901 no 137 0.0301627972833133 255 5006114
SGTC_2403 6032726 181.2 µM 1.87016083234048 0.0230740191593693 no 138 0.0307307434866352 277 2881040
SGTC_2440 5628896 157.78 µM 1.86045626583215 0.0236395416533954 no 139 0.031410500249277 233 5522048
SGTC_3135 9127742 49.47 µM 1.85509202276848 0.0239571084766945 no 140 0.0317915433818143 215 3643468
SGTC_164 4100-3994 89.624 µM 1.85445657525573 0.0239949638134755 no 141 0.0318369336240342 327 4615967
SGTC_1984 st072354 53.1 µM 1.85123920718888 0.0241874035356578 no 142 0.0320675737953136 228 5762938
SGTC_606 k015-0008 38.6 µM 1.8485225609001 0.0243509015449928 no 143 0.0322633918597533 292 1970475
SGTC_3070 9117005 49.47 µM 1.84474320277835 0.0245799001562973 no 144 0.0325374515324173 186 8779016
SGTC_1630 st005209 31.3 µM 1.84209954055396 0.0247411567110168 no 145 0.0327302955049504 314 3367314
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.83986560330769 0.0248781120344735 no 146 0.0328939855118748 362 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1904 st060225 78 µM 1.83982745094815 0.024880456540368 no 147 0.0328967869459337 249 66595
SGTC_3162 9099653 49.47 µM 1.83788778777309 0.0249998954470826 no 148 0.0330394710014364 202 25237511
SGTC_1653 st012112 65 µM 1.83664466175297 0.0250766960670473 no 149 0.0331311847685087 241 720429
SGTC_3154 9100113 49.47 µM 1.8354099161058 0.0251531746202158 no 150 0.0332224877815597 270 25237525
SGTC_394 menadione 8.33 µM 1.82369645661004 0.0258884615098521 no 151 0.0340989874259781 277 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1620 st003704 16.5 µM 1.81889474780614 0.0261950328991674 no 152 0.0344637446497224 230 2834414
SGTC_2136 5328288 199.296 µM 1.81480917768263 0.0264582661817501 no 153 0.03477661976009 239 262395
SGTC_3042 9091578 49.47 µM 1.80536856244201 0.027074988892465 no 154 0.0355085136119977 190 25236497
SGTC_919 tnp00227 403.569 nM 1.79839397150382 0.0275382810237524 no 155 0.0360572987135279 330 1269246 A methoxyflavone. YNL221C POP1
SGTC_2091 4-phenylthiadiazole 200 µM 1.79728027231261 0.0276128676960953 no 156 0.0361455682265305 300 270010
SGTC_3038 9091290 49.47 µM 1.79584616202823 0.0277091608902695 no 157 0.0362594934029907 274 25236843
SGTC_2437 5741531 144.16 µM 1.79540113959632 0.0277390987089618 no 158 0.0362949055191924 310 2262990
SGTC_3353 9151644 39.2805 µM 1.79335162406078 0.0278773230770531 no 159 0.0364583588114973 282 4909158
SGTC_426 0988-0037 14.6 µM 1.78750558449451 0.0282747501020472 no 160 0.0369279051671503 345 5383008
SGTC_266 formosanin C 406 nM 1.7726329807256 0.0293071254672504 no 161 0.038144771500993 338 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_798 1287-0182 476 µM 1.76630183144125 0.0297560019044985 no 162 0.038672612254736 339 1649755
SGTC_1212 0520-0165 585 µM 1.76288525735319 0.0300005961458355 no 163 0.0389599220058037 307 5403258
SGTC_1704 st028805 70.8 µM 1.75807405129214 0.0303478577095665 no 164 0.0393674551467705 274 2876101
SGTC_2709 st078560 56 µM 1.75684879679079 0.0304368238848873 no 165 0.0394717925726263 271 17250903
SGTC_1642 st009582 77.7 µM 1.7560406768511 0.0304956199393083 no 166 0.0395407316345943 270 6739311
SGTC_1775 st081588 35.1725 µM 1.75572718496074 0.0305184538560077 no 167 0.0395675013379855 324 1426443 YGL099W LSG1
SGTC_1980 st071811 45.7 µM 1.7541214571428 0.0306356329601742 no 168 0.0397048488647846 280 4974850
SGTC_442 cape 100 µM 1.74825164834298 0.0310671611420272 no 169 0.0402102308765783 255 5281787
SGTC_2736 butenafine 14.65 µM 1.73353765492883 0.0321710255385194 no 170 0.0415000753723873 361 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1748 st037455 53.6035 µM 1.72503243999851 0.032823732526214 no 171 0.0422608132501061 337 580690
SGTC_846 0335-0850 148 µM 1.72400495932219 0.0329033173523232 no 172 0.0423534739395538 273 6819598
SGTC_615 k087-0205 167 µM 1.72064101344479 0.0331649895391247 no 173 0.0426579931249673 294 9642773
SGTC_2857 9024691 58.44 µM 1.71943101868206 0.033259529956117 no 174 0.0427679590943031 301 16478292
SGTC_732 3970-1727 52.7 µM 1.71901301323316 0.0332922414809738 no 175 0.0428060012071553 270 1275699
SGTC_1624 st003710 6.25 µM 1.71752764237999 0.0334086954157731 no 176 0.0429414041289733 371 24207033
SGTC_652 0437-0092 114 µM 1.71352629971585 0.0337240725872192 no 177 0.0433078796099579 276 3091274
SGTC_399 oxolinic acid 75 µM 1.71339262598831 0.0337346506035572 no 178 0.0433201659952752 274 4628 A DNA gyrase inhibitor.
SGTC_2565 isoliquiritigenin 100 µM 1.70640570317677 0.0342913596571277 no 179 0.0439662847477939 273 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2519 cryptotanshinone 88.04 µM 1.70325576831097 0.0345448004261492 no 180 0.0442601071146212 271 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2904 7225135 42.03 µM 1.67845612253963 0.0365943512218336 no 181 0.0466290446527923 318 4446116
SGTC_920 mycophenolic acid 780.421 nM 1.67617155960084 0.0367880601640737 no 182 0.0468522966155358 346 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1525 8-methoxypsoralen 92.5 µM 1.66083646464968 0.0381101357583581 no 183 0.0483731477214564 392 4114 Related to psoralen; DNA damaging agent.
SGTC_2103 5378138 10 µM 1.6598401845884 0.0381973511734974 no 184 0.0484733036510452 355 244142
SGTC_1780 st038448 24.544 µM 1.65759731659682 0.0383942899640219 no 185 0.0486993858321497 338 728868 YDL195W SEC31
SGTC_1205 4161-2785 76 µM 1.65296286755538 0.0388038479046266 no 186 0.0491692104793734 319 3498106
SGTC_2396 5342950 42.78 µM 1.65272392913245 0.0388250595897988 no 187 0.0491935310299397 398 1886677
SGTC_1345 1488-0192 31.4 µM 1.65183453492099 0.0389040983054302 no 188 0.0492841432210046 351 658348
SGTC_1846 st056244 14.8 µM 1.65032157815961 0.0390388528114906 no 189 0.0494385905912034 384 5393182
SGTC_2963 9082507 9 µM 1.6451731035883 0.0395002612976444 no 190 0.0499670592288551 332 16459611
SGTC_2825 7998094 58.44 µM 1.64226289085316 0.0397630320790049 no 191 0.0502677670509183 350 2987815
SGTC_1705 st027868 56.3335 µM 1.63916512193498 0.0400442974991068 no 192 0.0505894377489911 301 292948
SGTC_984 1492-0255 2.91 µM 1.63558512883641 0.0403713584415095 no 193 0.0509632224124622 325 1585198
SGTC_938 3126-1755 342 µM 1.63273842225016 0.0406329731901741 no 194 0.0512620114301356 345 1777771
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.62864488707894 0.0410115827922799 no 195 0.0516941080453991 312 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_60 0986-0278 202 µM 1.62832101401533 0.0410416594342905 no 196 0.0517284179739345 255 3110598
SGTC_2959 9079155 11 µM 1.6212049092689 0.0417070265963246 no 197 0.0524868501335249 309 16189457
SGTC_165 k038-0023 64.381 µM 1.62037503320839 0.0417851869997353 no 198 0.0525758698441583 442 46368543
SGTC_3313 9133968 57.047 µM 1.61894805354658 0.0419198618614343 no 199 0.0527292202001418 377 1494643
SGTC_32 0928-0142 34.1 µM 1.61610757791801 0.0421889849731629 no 200 0.0530355280632706 300 2244242
SGTC_2812 7970281 58.44 µM 1.61461232908227 0.042331214214667 no 201 0.0531973369042157 391 2233435
SGTC_1464 k208-0027 110 µM 1.61195956207141 0.0425845018776794 no 202 0.0534853697999467 376 X1464
SGTC_2285 7945142 200 µM 1.60806545849008 0.0429585313875735 no 203 0.0539104216310179 360 2970608
SGTC_2942 9052777 62.25 µM 1.60656185593803 0.0431036612292261 no 204 0.054075257826907 413 6469503
SGTC_2903 5923464 63.88 µM 1.59912626148911 0.0438271873985832 no 205 0.0548962752669697 317 2876576
SGTC_1710 st031758 61.5 µM 1.59445475168985 0.044286741650436 no 206 0.0554171088179845 318 5394341
SGTC_1663 st014140 55.4 µM 1.591610508403 0.0445684376582279 no 207 0.0557361237262582 424 4207120
SGTC_1886 st057356 49.9 µM 1.58734122885807 0.0449939777788954 no 208 0.0562176911378324 358 24207747
SGTC_2090 5301565 104.445 µM 1.58680970963309 0.0450471850828224 no 209 0.056277874538654 421 2056344
SGTC_406 estrone 100 µM 1.58548179404614 0.0451803363143757 no 210 0.0564284550904834 375 5870 A steroid.
SGTC_2926 9010726 65.15 µM 1.58180151583405 0.0455510165290232 no 211 0.056847444440333 397 2994293
SGTC_2488 5268135 45.7 µM 1.58163874634005 0.0455674670866588 no 212 0.0568660317158502 474 1270356 YLR208W SEC13
SGTC_1983 st071813 46.9 µM 1.57787830240103 0.0459488540489738 no 213 0.0572967852795744 381 11838595
SGTC_2167 5876490 200 µM 1.57678934082057 0.0460597749325539 no 214 0.05742200254984 389 686534
SGTC_2518 prenyletin 46.28 µM 1.56697271671999 0.0470694265339411 no 215 0.0585605345044736 282 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1820 st053765 18.6 µM 1.56519723416218 0.0472539180614274 no 216 0.0587683349267843 360 3690829
SGTC_538 2922-0838 53.3 µM 1.5637302496686 0.047406790239465 no 217 0.0589404653397862 459 777039
SGTC_2844 9010103 25.97 µM 1.55947481319619 0.047852485600083 no 218 0.0594420206714431 429 2480525
SGTC_1101 ebselen 5.29 µM 1.55837447776252 0.0479682739995699 no 219 0.0595722515502156 398 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_502 l-744,832 89.3 µM 1.55564286633281 0.0482566912532228 no 220 0.059896519729908 404 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2851 9015922 71.43 µM 1.55266610203736 0.0485725708969933 no 221 0.0602514623318427 404 2996893
SGTC_1151 3909-8316 15.3 µM 1.54529246464134 0.0493621468128646 no 222 0.0611377686576699 405 800431
SGTC_1636 st007707 68.9 µM 1.5445529148438 0.0494419006777514 no 223 0.0612272213634983 451 403051
SGTC_2183 6420625 130.508 µM 1.54376655151637 0.0495268157627447 no 224 0.0613224485807023 471 2897619
SGTC_2415 st077333 57.7 µM 1.54272971015888 0.0496389564735375 no 225 0.061448185068006 476 2766255
SGTC_597 k018-0003 82.8 µM 1.54106124304148 0.0498198366104026 no 226 0.061650940682901 402 6786234
SGTC_2248 tofa 1.1 µM 1.54007410878812 0.0499271000989322 no 227 0.0617711450306438 361 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2704 st078022 71.1 µM 1.5393177376334 0.0500094130887208 no 228 0.0618633728609902 387 54697681
SGTC_2802 7925815 54.55 µM 1.53681291641853 0.0502827760330792 no 229 0.062169564748372 437 1262923
SGTC_222 nsc-310342 10.666 µM 1.53671498608145 0.050293487775503 no 230 0.0621815598231002 254 432556
SGTC_3340 9146634 11.102 µM 1.53112659247092 0.0509077721868449 no 231 0.0628690543645641 394 4907387
SGTC_325 2810-4341 181 µM 1.53048575628096 0.0509785939529368 no 232 0.0629482682487168 378 774970
SGTC_694 1315-0438 43.2 µM 1.53013581982704 0.0510173001383798 no 233 0.062991556769779 335 6793154
SGTC_821 1114-0266 29.2 µM 1.52525795736342 0.0515592756186553 no 234 0.0635973848686523 390 3123235
SGTC_2720 fluspirilene 36.88 µM 1.52396110130441 0.0517041360061655 no 235 0.0637592142614391 333 3396 An atypical antipsychotic.
SGTC_3298 9116858 71.43 µM 1.5234900749372 0.0517568302455657 no 236 0.0638180709639622 402 2506942
SGTC_2523 spermine 47.74 µM 1.5231435376733 0.0517956249992791 no 237 0.0638613992112131 386 1103 A DNA binding polyamine.
SGTC_158 k038-0087 26.446 µM 1.52008284950312 0.0521392725521386 no 238 0.0642450772217533 551 X158
SGTC_1804 st050076 49.1 µM 1.51863888286714 0.0523020255702326 no 239 0.0644267091148511 411 3895976
SGTC_2894 9048625 32.47 µM 1.51748675183199 0.0524321742184805 no 240 0.0645719179227213 390 4092861
SGTC_3203 9113543 49.47 µM 1.51049306664106 0.0532277304899964 no 241 0.0654588286068133 423 17018012
SGTC_1118 chelidonine 707.474 nM 1.50888661833599 0.0534118142934936 no 242 0.0656638800507153 437 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1927 st060202 13.8 µM 1.50186012529093 0.0542229202803165 no 243 0.0665666182443826 399 688887
SGTC_1371 2421-0008 32.7 µM 1.49606949967003 0.0548986631140643 no 244 0.0673177725301113 438 2827552
SGTC_352 k048-0007 5.11 µM 1.4951984615536 0.0550008831762941 no 245 0.0674313274665719 478 6811911
SGTC_559 1550-0661 158 µM 1.49433961007428 0.0551018202798434 no 246 0.0675434385590755 412 5830875
SGTC_80 0159-0065 512.242 µM 1.49263598380388 0.0553024731290094 no 247 0.0677662493798875 280 1548079
SGTC_3000 9075062 71.4286 µM 1.48725891246312 0.0559395705302049 no 248 0.0684732208996382 409 17057871
SGTC_302 1094-0063 18.9 µM 1.47948409857359 0.0568709836104406 no 249 0.069505489081248 364 5440289
SGTC_327 1273-0057 3.96 µM 1.47861221240055 0.0569761916580623 no 250 0.0696219934370504 412 3108138
SGTC_2201 6605497 169.863 µM 1.47573024530928 0.0573250412419844 no 251 0.0700081615552283 395 670741
SGTC_281 1672-3440 14.9 µM 1.47303668239534 0.0576526027128941 no 252 0.0703705724447034 459 6833000
SGTC_2081 5214970 32.255 µM 1.4729865711412 0.0576587106095603 no 253 0.070377328407263 423 2063512
SGTC_491 tetrandrine 80.3 µM 1.47240246566358 0.0577299428541453 no 254 0.070456113869465 360 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3133 9127736 49.47 µM 1.46869722506739 0.0581834135186934 no 255 0.07095746523406 435 27243420
SGTC_2012 4023501 200 µM 1.46833744983398 0.0582275937225638 no 256 0.0710062915472691 416 3477460
SGTC_3218 9131285 49.47 µM 1.46342513514426 0.0588334633415261 no 257 0.0716755425450557 527 17156417
SGTC_570 0987-0065 62.6 µM 1.46130384825544 0.0590966209095792 no 258 0.0719660371293731 330 3104428
SGTC_2657 nystatin 74.44 µM 1.45356227427526 0.0600648465264101 no 259 0.0730338513058942 459 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2687 chenodiol 100 µM 1.45210076483268 0.0602490211551681 no 260 0.073236794660543 432 5702181 A cholesterol synthesis inhibitor.
SGTC_334 1502-1024 68.5 µM 1.45003388039631 0.0605102374214067 no 261 0.0735245357628349 465 3296216
SGTC_444 curcumin 90.4 µM 1.44646821356482 0.06096295417895 no 262 0.0740229606326223 470 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_284 0988-0104 32.6 µM 1.44589122056144 0.0610364606659518 no 263 0.0741038573895207 476 4666532
SGTC_1096 rimcazole 32.2 µM 1.44416425069692 0.0612568834153202 no 264 0.0743463891449501 410 18528119 A dopamine reuptake inhibitor.
SGTC_1733 st037357 54.9 µM 1.44254308450719 0.0614643673741388 no 265 0.0745746131716931 494 1272339 YGL099W LSG1
SGTC_1047 2043-3044 82 µM 1.43941617826954 0.0618661125601289 no 266 0.0750163216568012 475 669592
SGTC_1602 st001878 87.6 µM 1.43929570950513 0.0618816313022428 no 267 0.0750333789728194 433 595405 YLR310C CDC25
SGTC_1899 st063254 59.6 µM 1.43923743807081 0.0618891388972438 no 268 0.075041630756063 389 3093813
SGTC_1108 betulinic acid 729.144 nM 1.43766928073179 0.062091444792305 no 269 0.0752639566024806 463 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_169 k015-0017 16.025 µM 1.43511333736203 0.0624222890062636 no 270 0.0756274017625825 418 1840002
SGTC_2462 5162487 171.77 µM 1.4334945712552 0.0626325338491171 no 271 0.0758582746160556 449 2259986
SGTC_1385 3091-4834 14.1 µM 1.43310608963609 0.0626830717543922 no 272 0.0759137607089576 423 4072814
SGTC_1783 st039459 87.517 µM 1.43063938707029 0.0630047091318634 no 273 0.0762667965229177 509 729761
SGTC_725 1497-0963 19 µM 1.42634439942248 0.0635678057229567 no 274 0.076884477237293 459 3549977
SGTC_2895 9054447 58.44 µM 1.42556813910185 0.0636699943205941 no 275 0.0769965192349933 416 2697450
SGTC_2628 lathosterol 100 µM 1.42266096615357 0.064053836857949 no 276 0.0774172306366503 475 6710616
SGTC_1827 berberine 7.24 µM 1.42197274479632 0.0641449675763976 no 277 0.0775170816685871 425 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1972 st070201 17.4 µM 1.41857674857671 0.0645961243118575 no 278 0.0780112243043071 464 2829099
SGTC_792 4534-1957 155 µM 1.41606933397333 0.0649308121787858 no 279 0.0783776027823756 451 1717904
SGTC_734 2023-0417 80 µM 1.41514271880414 0.0650548361946408 no 280 0.0785133276270517 485 3935732
SGTC_685 1278-0033 54.9 µM 1.40522924318233 0.0663932501452191 no 281 0.0799765604791425 508 3590572
SGTC_2954 9074818 52.69 µM 1.40137961425801 0.0669186973182188 no 282 0.0805502925115463 469 16648742
SGTC_186 3455-3465 67.277 µM 1.40055986468271 0.067031001677103 no 283 0.0806728649618154 355 755278
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.3958830570113 0.0676745069031344 no 284 0.0813748567772553 519 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2738 aclarubicin 5.55 µM 1.39481600966856 0.067821993766922 no 285 0.0815356649163776 370 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2912 7964298 10.93 µM 1.39392155734998 0.0679458157770994 no 286 0.081670646849733 558 2975850
SGTC_237 nikkomycin 200 µM 1.39064870897095 0.0684003753818649 no 287 0.0821659890752111 504 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_702 1488-0190 94 µM 1.38907825787924 0.0686193236833806 no 288 0.0824044771928573 463 949357
SGTC_3169 9102970 49.47 µM 1.38854378543005 0.0686939616326247 no 289 0.0824857607409062 454 17027839
SGTC_2390 9097792 176.6 µM 1.38643036260964 0.0689897100242247 no 290 0.0828077652505614 455 4497149
SGTC_1657 st012939 43.4 µM 1.38553634771854 0.0691151117659099 no 291 0.0829442631190202 440 24207257
SGTC_421 streptovitacin 30 mM 1.38430531052493 0.0692880743367414 no 292 0.0831324943225349 534 91467 include heat shock
SGTC_326 k292-0812 17.5 µM 1.38273516056443 0.0695091664051105 no 293 0.0833730433318293 458 3579357
SGTC_1160 4092-0570 10.5 µM 1.38056122758645 0.0698161731598391 no 294 0.0837069558436469 520 4994975
SGTC_1442 4112-3290 3 µM 1.3803279210445 0.0698491830465739 no 295 0.0837428509537371 507 704353
SGTC_1605 st000082 49.1 µM 1.37659220218793 0.0703793767945801 no 296 0.0843191815589803 465 1114022
SGTC_1377 2944-0135 198 µM 1.37201477430214 0.0710332428185897 no 297 0.0850294192755962 520 1894137
SGTC_2546 rhodinyl acetate 100 µM 1.36120265745796 0.0725962246415414 no 298 0.0867248273046088 513 6708682
SGTC_3219 9131112 49.47 µM 1.35670341283905 0.0732543363106088 no 299 0.0874377338249737 486 17612988 YMR079W SEC14
SGTC_3190 9110366 49.47 µM 1.35627539192774 0.0733171805987666 no 300 0.087505781038199 424 17123768
SGTC_1435 4092-0789 56.7 µM 1.35589487069958 0.0733730853553165 no 301 0.0875663098812516 501 2248285
SGTC_3075 9116269 49.47 µM 1.35118276221397 0.074068075150072 no 302 0.0883184475076965 518 17015205 YNL244C SUI1
SGTC_2200 6600604 21.907 µM 1.3493064943191 0.0743462019866277 no 303 0.088619270260424 543 2904777
SGTC_3302 9125395 16.351 µM 1.34477296123419 0.0750215167614814 no 304 0.0893492822770599 485 17599668
SGTC_3314 9135860 59.4275 µM 1.34404166898802 0.0751308868188789 no 305 0.0894674563982031 524 25252478
SGTC_2473 5854593 8.94 µM 1.34270531423221 0.075331062392372 no 306 0.0896837066288358 476 2872951
SGTC_478 N-arachidonylglycine 10 µM 1.34055036159003 0.0756547135879089 no 307 0.0900332413913768 379 5283389
SGTC_728 3030-5151 22.5 µM 1.33995965160678 0.0757436167368109 no 308 0.0901292314770499 477 3125388
SGTC_745 0469-0705 296 µM 1.33813054166353 0.0760194065209316 no 309 0.0904269431416485 583 3486736
SGTC_2061 5245884 80.95 µM 1.3373052881936 0.0761440867009672 no 310 0.0905615027727446 538 573863
SGTC_2971 9092186 9.93 µM 1.33707723841127 0.0761785681416632 no 311 0.0905987130569364 472 25236400
SGTC_769 0302-0231 76 µM 1.33357831827002 0.0767091008164633 no 312 0.0911710462901245 620 571869 YER009W NTF2
SGTC_2110 5483698 200 µM 1.33340055935805 0.0767361287724957 no 313 0.0912001944746722 503 2848765 YHR062C RPP1
SGTC_195 4234-0266 16.654 µM 1.33322033645696 0.076763538766129 no 314 0.0912297537481171 577 2303354
SGTC_1510 1123-0200 71.5 µM 1.33255563694558 0.0768646968835056 no 315 0.0913388359086337 605 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_280 3448-3607 3.04 µM 1.3260549097784 0.0778593664736812 no 316 0.0924107550211382 503 626179
SGTC_88 0180-0332 8.668 µM 1.3227491117107 0.0783689154121319 no 317 0.0929594126735639 531 3101745
SGTC_662 k832-1615 104 µM 1.32269001563612 0.0783780473096828 no 318 0.0929692426097966 523 5878478
SGTC_2411 st077133 39.94 µM 1.32086593755564 0.078660312298692 no 319 0.0932730345432541 605 1403142 YNL221C POP1
SGTC_279 1273-0055 2.93 µM 1.31855672516272 0.0790187530125465 no 320 0.0936586745936393 580 2847562
SGTC_2529 gangaleoidin 93.61 µM 1.31405112738121 0.0797216807940869 no 321 0.0944144996386772 517 4565183
SGTC_2692 st077426 47.7 µM 1.30932991970815 0.0804633107629842 no 322 0.0952113094582801 546 25238571
SGTC_974 1326-0144 138 µM 1.30874355324096 0.0805557827101718 no 323 0.0953106166361403 561 5411856
SGTC_784 4579-0127 173 µM 1.30802004697201 0.0806699926662496 no 324 0.0954332549181039 564 1948547
SGTC_211 3455-0679 143.504 µM 1.30659148192694 0.08089585957048 no 325 0.0956757455554298 560 748649
SGTC_3295 9122362 53.5725 µM 1.30643503156986 0.080920624527733 no 326 0.0957023296150826 506 4730473
SGTC_2777 climbazole 1.536 µM 1.30629510609077 0.0809427785644906 no 327 0.0957261103693554 580 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1446 4239-0190 62 µM 1.30157666310138 0.0816925203816145 no 328 0.0965305708721181 600 1340085
SGTC_894 0960-0238 55.9 µM 1.30138458646973 0.0817231511196248 no 329 0.0965634234420804 553 6741907 YDL195W SEC31
SGTC_1100 amiodarone 5.07 µM 1.29837892164609 0.0822035972324214 no 330 0.0970785793047245 571 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_3333 9141820 12.094 µM 1.29541574792752 0.0826793307775204 no 331 0.0975884241950976 494 1939433
SGTC_3146 9095609 49.47 µM 1.29522915335659 0.0827093574865392 no 332 0.0976205953273173 538 17173999
SGTC_1654 st012436 41.8 µM 1.2932391176058 0.0830301037232459 no 333 0.0979641851129725 504 4323132
SGTC_2855 9016525 58.44 µM 1.29321896188112 0.0830333571235729 no 334 0.0979676696289372 549 43811474
SGTC_540 1187-0821 17.3 µM 1.29254071537252 0.0831428909788529 no 335 0.0980849776512774 531 847520
SGTC_2856 9022925 19.48 µM 1.28503510284833 0.0843622779802098 no 336 0.0993900088638476 573 4944862
SGTC_1509 1326-1131 80 µM 1.284899780254 0.08438438544413 no 337 0.0994136538790703 509 768313
SGTC_892 0929-0076 29 µM 1.28474209460739 0.0844101518124664 no 338 0.0994412115937098 603 5751038
SGTC_3310 9130229 44.1445 µM 1.2813860265213 0.0849599454573817 no 339 0.100029054904169 550 7761258
SGTC_1061 3448-9325 110 µM 1.27834034021976 0.085461211614734 no 340 0.100564724942009 525 723482
SGTC_102 gallobenzophenone 83.616 µM 1.27693451512155 0.0856933313750173 no 341 0.100812683713533 596 70837
SGTC_462 ag-879 158 µM 1.27523731583576 0.0859741892343273 no 342 0.101112628557073 597 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2391 6285546 200 µM 1.26846629602434 0.08710153649767 no 343 0.102315739736128 591 846083
SGTC_366 0181-0206 4.31 µM 1.26777082958241 0.0872179511376747 no 344 0.102439901081766 592 274874
SGTC_860 0443-0016 25.1 µM 1.26413748640407 0.087828028615478 no 345 0.103090341904852 569 5337942
SGTC_83 0170-0301 39.027 µM 1.26346829629985 0.0879407391165448 no 346 0.103210466654761 442 3089716
SGTC_635 k038-0028 24.7 µM 1.2628471318968 0.0880454572326518 no 347 0.10332206135469 583 4035102
SGTC_1408 3909-7976 48.8 µM 1.26266095851424 0.0880768611087673 no 348 0.1033555252124 643 24152374
SGTC_2642 cholecalciferol 100 µM 1.25897413579649 0.0887004786639773 no 349 0.104019837048003 531 9821465 A vitamin D precursor, similar to steriods.
SGTC_1146 3579-1023 7 µM 1.25732186988383 0.0889810203293721 no 350 0.10431855392938 639 X1146
SGTC_1845 st056753 3.01 µM 1.25585255037654 0.0892310535179391 no 351 0.104584717344559 595 5375839
SGTC_72 0744-0168 198.391 µM 1.25416149780871 0.0895194655057047 no 352 0.104891655615433 574 677577
SGTC_1399 3562-5772 25 µM 1.25290276562772 0.0897345941520156 no 353 0.105120547641325 497 23847490
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.25208889373717 0.0898738966208145 no 354 0.105268737095632 468 1241132 A phosphatase inhibitor.
SGTC_1907 st060210 83.7 µM 1.25061918242315 0.0901258597687731 no 355 0.1055367243253 642 688793
SGTC_1645 Cervolide 78 µM 1.24303033165347 0.0914352260774384 no 356 0.106928328238576 535 23173 A fragrance.
SGTC_1967 st070177 51.4 µM 1.23831493127504 0.0922558843573041 no 357 0.107799654757247 556 5729214
SGTC_918 glabranin 770.725 nM 1.23713248055724 0.0924625279418033 no 358 0.108018951533448 601 124049 Also referred to as licorice root.
SGTC_1239 0337-0584 35.4 µM 1.23648715482737 0.0925754485995812 no 359 0.108138768752894 641 914301 YML130C ERO1
SGTC_1656 st012921 11 µM 1.23461902699714 0.0929029132034051 no 360 0.108486162158393 540 6732821
SGTC_1087 pterostilbene 9.05 µM 1.22937805771916 0.0938261743536853 no 361 0.109465046593912 631 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2487 5918373 44.05 µM 1.22396058255247 0.0947876296260357 no 362 0.110483548821727 635 2876279
SGTC_1211 1056-0033 32.3 µM 1.22251285432128 0.0950457872942375 no 363 0.110756872942125 618 6741922
SGTC_2445 5742597 35.57 µM 1.22240540754053 0.095064967737307 no 364 0.110777177674196 580 1774255
SGTC_936 3005-4620 401 µM 1.22183284824434 0.0951672240024305 no 365 0.110885421918639 669 777207
SGTC_1552 6-methylflavone 10.6 µM 1.22109686425751 0.0952987860601317 no 366 0.1110246734174 548 689013
SGTC_25 0118-0223 35.662 µM 1.22084893577365 0.0953431350722558 no 367 0.111071610798192 583 5333628
SGTC_528 3492-0019 172 µM 1.21763682794054 0.0959190854983818 no 368 0.111681006443063 826 2869262
SGTC_1486 3970-0793 4.53 µM 1.21752699183222 0.0959388249248147 no 369 0.111701886572117 619 2844330
SGTC_2463 5473429 200 µM 1.21578669297297 0.0962519851531838 no 370 0.112033094621852 592 5399405
SGTC_86 0417-1630 471.922 µM 1.21558550608428 0.0962882363712353 no 371 0.112071429088034 726 3634867
SGTC_2919 7978188 46.38 µM 1.21426902971096 0.0965256957091544 no 372 0.112322504012948 617 2980291
SGTC_2262 9014885 67.46 µM 1.21192305276081 0.0969499171088722 no 373 0.11277091840014 506 6457424
SGTC_2893 9048488 25.97 µM 1.20432361133708 0.0983335152831749 no 374 0.114232262060247 591 6467338
SGTC_2131 toluylene red 5.2905 µM 1.20185897327391 0.0987853323524491 no 375 0.114709086082426 611 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1311 1190-0148 100 µM 1.19952298065597 0.0992149667049938 no 376 0.115162327239747 732 1961333
SGTC_1832 st054113 55 µM 1.19644898633322 0.0997824137788604 no 377 0.115760697368594 579 1251267
SGTC_1166 k206-0078 225 µM 1.19465723753228 0.100114255205566 no 378 0.116110488184917 655 5404595
SGTC_1448 4255-0083 152 µM 1.19251952560074 0.100511224065848 no 379 0.116528799647355 643 5399660
SGTC_3161 9100388 49.47 µM 1.19170927249292 0.100661986195934 no 380 0.116687630495176 621 25236368
SGTC_1350 1495-0454 146 µM 1.18552148409425 0.101818777775794 no 381 0.117905662692236 693 1069057
SGTC_3194 9111903 49.47 µM 1.18456884023953 0.101997728290335 no 382 0.118093981551879 621 17087251
SGTC_2643 anethole 100 µM 1.18320904639145 0.102253556708155 no 383 0.118363154302104 663 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1260 0700-1617 7.75 µM 1.18215316631766 0.102452529176047 no 384 0.118572465907595 655 2853078
SGTC_1181 1222-0449 220 µM 1.18024268521788 0.102813259855351 no 385 0.118951853225794 650 658318
SGTC_2665 lovastatin 100 µM 1.17526426089921 0.103757603452918 no 386 0.119944504048047 624 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_3139 9095020 49.47 µM 1.17390430496642 0.104016660570505 no 387 0.120216678969463 491 25236292
SGTC_2732 terfenadine 20 µM 1.17370885137905 0.104053930909649 no 388 0.120255831829473 589 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2763 lisinopril 49.32 µM 1.17250716606164 0.10428328873224 no 389 0.120496748370573 597 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_3039 9090270 49.47 µM 1.17022472820906 0.104719931205434 no 390 0.120955272006456 597 17173750
SGTC_1247 0448-0043 5.84 µM 1.16606563758312 0.105518989024283 no 391 0.121793954227235 688 3089013 YGL099W LSG1
SGTC_1508 1080-0625 72.9 µM 1.16562114535346 0.105604646401411 no 392 0.121883827323768 614 767111
SGTC_917 harmaline 728.087 nM 1.16528451481793 0.105669551376888 no 393 0.121951922563809 654 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1306 1185-0270 9.02 µM 1.16489219887443 0.105745229317239 no 394 0.122031315827376 706 1548076
SGTC_1539 benzyladenosine 56 µM 1.16371248985152 0.105973031809095 no 395 0.122270273063882 621 92208 A nucleotide analog.
SGTC_2685 mycophenolic acid 18.85 µM 1.16294543899272 0.106121339896894 no 396 0.122425819987178 611 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_684 1140-0066 328 µM 1.16099716551943 0.106498709505183 no 397 0.122821526073566 701 6813534
SGTC_1795 st049545 62.3 µM 1.16053699468394 0.106587983273211 no 398 0.12291512034367 631 5291882
SGTC_808 0711-0032 135 µM 1.15993798754487 0.106704272380423 no 399 0.123037027466976 656 4252555
SGTC_1312 1218-2183 165 µM 1.15942341717289 0.106804242325303 no 400 0.123141818072743 683 6744073
SGTC_1072 oxiconazole 14.9 nM 1.15762505987875 0.107154155225525 no 401 0.123508539028424 689 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_476 mead acid 10 µM 1.15625680422283 0.107420934910124 no 402 0.123788065583356 580 5312531 An omega 9 fatty acid.
SGTC_365 0121-0052 13.6 µM 1.15463308950335 0.107738144236078 no 403 0.124120355167765 718 3101739
SGTC_466 geldanamycin 89.2 µM 1.15247944019072 0.108159922019581 no 404 0.124562056767152 525 5288382 HSP90 inhibitor.
SGTC_961 1252-1571 372 µM 1.15124742512566 0.108401737718353 no 405 0.124815229799142 672 6813498
SGTC_1032 k061-1018 98.7 µM 1.1510890300079 0.108432855169119 no 406 0.124847805283102 748 4005393
SGTC_3001 9076041 71.4286 µM 1.15088946542216 0.108472069700622 no 407 0.124888856121732 632 16004211
SGTC_848 0368-0089 85.6 µM 1.1493950669946 0.108766043969823 no 408 0.125196556618206 685 762535
SGTC_2123 5259487 200 µM 1.1473022546697 0.109178699002451 no 409 0.125628361253126 699 2173474
SGTC_2804 7954240 19.48 µM 1.14667281390357 0.109303030192402 no 410 0.125758435188505 708 828705
SGTC_2350 9023895 38.85 µM 1.14518862508119 0.109596599324437 no 411 0.126065514648988 657 2997209
SGTC_2785 7756463 72.73 µM 1.144275343181 0.109777525515679 no 412 0.126254732767399 639 2201551
SGTC_3181 9108277 49.47 µM 1.14027585400958 0.110572371588113 no 413 0.127085697058694 641 17097298
SGTC_2115 tiliquinol 12.7705 µM 1.14019232627295 0.110589015492949 no 414 0.127103091893789 659 71208 A bioactive hydroxyquinoline.
SGTC_949 1165-0505 146 µM 1.14005639346782 0.110616105576143 no 415 0.127131403741748 719 6244267
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.13456293769526 0.111714880621381 no 416 0.128279244668052 649 803109
SGTC_998 3996-0085 177 µM 1.13265388584583 0.112098542129908 no 417 0.128679815046824 746 715391
SGTC_2656 pseudo-anisatin 100 µM 1.13219268718628 0.112191370163055 no 418 0.128776716944378 662 6708809 A neurotoxin.
SGTC_179 1273-0063 6.77 µM 1.13150097507251 0.112330697902647 no 419 0.128922146628088 613 3108139
SGTC_999 SEC7.066 22.7 µM 1.13134595583292 0.112361939521297 no 420 0.128954754416676 728 740511 YDR170C SEC7
SGTC_147 4466-0538 29.23 µM 1.13069424878606 0.112493348441609 no 421 0.129091901422006 696 6742687 YHR072W ERG7
SGTC_2334 9017922 200 µM 1.13004959614517 0.112623442898179 no 422 0.129227663341612 692 3163164
SGTC_1611 st001856 99.4 µM 1.12924349365275 0.112786269962208 no 423 0.129397565326672 654 647478
SGTC_1987 st072290 61.9 µM 1.12429289178287 0.113789943257267 no 424 0.130444396447914 705 54697379
SGTC_887 0885-0007 9.62 µM 1.12356320753004 0.113938414311946 no 425 0.130599185966961 712 5719458
SGTC_2868 9035608 32.47 µM 1.12354528559314 0.113942062678405 no 426 0.130602989383994 671 6462614
SGTC_1713 st033146 12.748 µM 1.12255691983865 0.114143393060132 no 427 0.130812860249175 693 674619
SGTC_3226 9131256 49.47 µM 1.1213176915511 0.114396182051278 no 428 0.131076328781915 571 17178073
SGTC_2744 captopril 92.04 µM 1.12102257868315 0.114456440558551 no 429 0.131139125833193 615 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3158 9100007 49.47 µM 1.12012926344006 0.114638982523539 no 430 0.13132934098553 603 19297233
SGTC_616 4092-0450 108 µM 1.11888104508734 0.114894393003544 no 431 0.131595445218091 720 787165
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.1171479276458 0.115249694331556 no 432 0.131965540450499 683 390807
SGTC_2363 9053361 176 µM 1.11685256468129 0.115310323640413 no 433 0.13202868469351 695 6469797 YMR079W SEC14
SGTC_1767 st044992 70.3 µM 1.11396603223298 0.115904037259923 no 434 0.132646879615731 677 9600693
SGTC_2383 9036125 200 µM 1.10983232261684 0.11675805010289 no 435 0.133535644065589 654 79580
SGTC_1284 0929-0043 16 µM 1.10501836942209 0.11775821055905 no 436 0.134575814785527 717 1239883
SGTC_835 0312-0010 67.2 µM 1.10312923139556 0.118152354998406 no 437 0.134985524114435 658 1626196
SGTC_2520 obtusaquinone 4.71 µM 1.10107199773063 0.11858263057467 no 438 0.135432661590721 709 5967872
SGTC_2651 TUB2.036 5 µM 1.09969617173153 0.118871005193276 no 439 0.135732261656984 877 15992207 YFL037W TUB2
SGTC_2418 pentamidine 31.67 µM 1.09589979460692 0.119669297795428 no 440 0.136561314492187 660 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2305 7443522 69.23 µM 1.0944495565872 0.119975245997937 no 441 0.136878929719356 757 5415886
SGTC_306 1672-3436 11.6 µM 1.09212433608807 0.120466934043744 no 442 0.137389227015315 724 6797378
SGTC_2943 9068529 45.32 µM 1.09204087874315 0.120484608166572 no 443 0.137407566840193 764 3270634
SGTC_220 paclitaxel 373.376 µM 1.08745153842855 0.121459325122398 no 444 0.138418652357441 645 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_189 3970-0742 2.116 µM 1.08558765165655 0.121856769361992 no 445 0.138830732695853 706 2891807
SGTC_1296 1068-0102 11.9 µM 1.08502278303226 0.12197739881785 no 446 0.138955782356364 726 767053
SGTC_1414 3917-0015 5.4 µM 1.08115900311844 0.122804770088247 no 447 0.139813195487162 705 6618702
SGTC_3321 9137793 26.8275 µM 1.08031145688333 0.122986784691194 no 448 0.140001754787036 726 4904192
SGTC_1998 st075797 76.8 µM 1.07805124739488 0.123473099897527 no 449 0.140505443320769 819 24208315
SGTC_1323 1348-1351 11.2 µM 1.07641294748678 0.123826443661315 no 450 0.140871307193062 705 6989654
SGTC_110 0850-0284 111.64 µM 1.07544399270428 0.124035757821413 no 451 0.141087997327965 597 3906265
SGTC_730 1436-0052 41.2 µM 1.07378267677605 0.12439521213016 no 452 0.141460047929313 696 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1228 0124-0032 52.5 µM 1.07316354865768 0.124529357299638 no 453 0.141598871164563 741 X1228
SGTC_1413 3910-0535 34.4 µM 1.0725851665421 0.124654765458982 no 454 0.141728641537317 759 2876951
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.07137388037415 0.124917689488417 no 455 0.142000676187712 763 5106787 A p450 inhibitor.
SGTC_37 0566-0070 1.56 µM 1.0693928763645 0.125348524391038 no 456 0.142446337945207 788 1626686
SGTC_182 3448-4371 550.524 µM 1.06742508117169 0.125777512479945 no 457 0.14288996383654 791 3491403
SGTC_573 3702-0553 84.7 µM 1.06695152539402 0.125880902442539 no 458 0.142996862972479 714 1222756
SGTC_1494 4358-1428 177 µM 1.06632075464215 0.126018708693942 no 459 0.143139335277313 767 1564571
SGTC_544 k015-0020 52.4 µM 1.06303811298727 0.12673757457006 no 460 0.143882333860756 729 3008304
SGTC_1791 st048313 56.1 µM 1.06060669188729 0.127271869060956 no 461 0.144434340056968 684 1204976
SGTC_764 1951-2361 146 µM 1.06001120992954 0.127402962224333 no 462 0.144569749760506 720 5438930
SGTC_2892 9047358 58.44 µM 1.05660779058549 0.128154014577333 no 463 0.145345311754594 682 6466771
SGTC_2611 pyromycin 23.93 µM 1.055132743579 0.128480475077947 no 464 0.145682309285563 713 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1917 st066507 28.5 µM 1.05026931654629 0.129560946293828 no 465 0.146797154065316 769 3156428
SGTC_1950 st077106 7.18 µM 1.04979730585612 0.129666143491397 no 466 0.146905657098088 757 13831864
SGTC_2451 5856223 45.7 µM 1.04898656991948 0.129846970554948 no 467 0.147092149807901 738 2179896
SGTC_855 0428-0020 25 µM 1.04806611017331 0.130052482046276 no 468 0.147304074502358 688 6812414
SGTC_3264 9137442 49.47 µM 1.04618994515376 0.130472071129089 no 469 0.147736672124569 711 17015726
SGTC_3229 9132204 49.47 µM 1.04383379398383 0.131000330106255 no 470 0.1482811467234 735 17682924
SGTC_2439 5492030 7.2 µM 1.04284674630827 0.131222068951124 no 471 0.148509638530035 739 5722370
SGTC_2023 5144124 124 µM 1.04167647408962 0.131485304620464 no 472 0.148780849907073 750 2830192
SGTC_1892 st058411 7.36 µM 1.04136358045184 0.131555747199611 no 473 0.14885341926756 815 3934738
SGTC_574 1315-0397 40 µM 1.03987401621283 0.131891453922414 no 474 0.149199217904632 879 6794277
SGTC_1236 0330-0013 258 µM 1.03888075522947 0.132115635692777 no 475 0.149430098863418 733 4617066
SGTC_1115 galangin 695.678 nM 1.03840125594215 0.132223953999751 no 476 0.149541642548243 814 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3163 9099914 49.47 µM 1.0362427091327 0.132712325143677 no 477 0.150044463192617 725 16268368
SGTC_523 1934-0222 13.7 µM 1.03521698182024 0.132944830836979 no 478 0.150283794909565 754 1361595
SGTC_1456 k015-0012 13 µM 1.03446719015936 0.133114966420769 no 479 0.150458903759367 852 2989616
SGTC_2761 levamisole 97.89 µM 1.03138331007452 0.13381630644543 no 480 0.151180552172657 746 26879 An alkaline phosphatase inhibitor.
SGTC_840 0245-0196 390 µM 1.03007976816314 0.134113521996367 no 481 0.151486280871673 820 3827528
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.02637200754512 0.134961392361764 no 482 0.152358133693814 735 689007
SGTC_1698 5-fluorocytosine 1.055 µM 1.02629774603304 0.134978411550128 no 483 0.152375629700013 779 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2188 6126565 140.678 µM 1.02587489300447 0.135075348691844 no 484 0.152475279253727 728 874518
SGTC_2677 mitomycin C 100 µM 1.0247488601417 0.135333719422847 no 485 0.152740851054735 724 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.02340870025747 0.135641663313958 no 486 0.153057323760081 843 1377
SGTC_1288 0973-0013 65.5 µM 1.01938189299259 0.136569835457915 no 487 0.154010849499184 805 4315430
SGTC_2799 7812892 81.82 µM 1.01734087054368 0.137041942531689 no 488 0.154495650104343 825 20205235
SGTC_1367 1812-0510 76.9 µM 1.01485797737895 0.137617760097727 no 489 0.155086766067515 771 1142582 YDR527W RBA50
SGTC_2754 granisetron 64.02 µM 1.01363258916152 0.137902552484475 no 490 0.155379050585996 779 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2107 5363541 170.161 µM 1.01124425488939 0.138458779859008 no 491 0.155949769682322 821 244052
SGTC_1861 st057647 17.4 µM 1.00985628593506 0.138782730214197 no 492 0.156282074381822 801 688668
SGTC_377 3970-0964 33.1 µM 1.00919205247427 0.138937944026393 no 493 0.156441268707222 883 16481235
SGTC_338 4055-0136 114 µM 1.00563784116198 0.139770477149064 no 494 0.157294906950764 777 2900563
SGTC_2062 5245942 200 µM 1.00468588240415 0.139994037164061 no 495 0.157524064096755 837 1376160
SGTC_3086 9117350 49.47 µM 1.00408095934066 0.140136224773583 no 496 0.157669796155421 751 2679265
SGTC_1009 4106-0057 9.87 µM 1.00394637534062 0.140167872178412 no 497 0.157702230837488 852 2928005
SGTC_1970 st070122 35.8 µM 1.00303732093363 0.140381763313441 no 498 0.157921427311328 773 102928
SGTC_3140 9094243 49.47 µM 1.00299502945474 0.14039171945498 no 499 0.157931629745786 852 19291112
SGTC_3202 9113761 49.47 µM 1.0023690192968 0.140539149089237 no 500 0.158082699615569 864 4798415
SGTC_760 0568-0725 82.9 µM 0.999474091604545 0.141222290644238 no 501 0.158782541829022 863 3916171
SGTC_2622 2-methoxyxanthone 59.94 µM 0.999432943146735 0.141232017007415 no 502 0.158792503992347 854 71034 A hepatoprotective.
SGTC_67 0335-0847 266 µM 0.997518157707514 0.141685121899721 no 503 0.159256532322666 910 4552207 YOR254C SEC63
SGTC_2220 6782180 200 µM 0.997039045258792 0.1417986504301 no 504 0.159372779003183 711 833803
SGTC_481 bay k-8644 50 µM 0.995668274724095 0.142123802820601 no 505 0.159705674778228 736 2303 A calcium channel antagonist.
SGTC_779 1360-0071 233 µM 0.995513874716861 0.142160458731336 no 506 0.159743199777465 859 7566
SGTC_2376 9072922 81.32 µM 0.995039529277865 0.142273112503104 no 507 0.159858519612291 817 17087968
SGTC_2627 acetyl isogambogic acid 100 µM 0.994179187844301 0.142477591758134 no 508 0.160067819251285 750 6857789 A caspase activator and apoptosis inducer.
SGTC_1355 1499-0035 1.68 µM 0.993411557088124 0.142660203980052 no 509 0.160254715880044 785 1548538
SGTC_163 TUB2.036 7.546 µM 0.992649402904317 0.142841669872908 no 510 0.160440420171096 928 15992207 YJR013W GPI14
SGTC_3136 9095672 49.47 µM 0.991776318156769 0.143049739547583 no 511 0.160653326205078 712 17217380
SGTC_3212 9128307 49.47 µM 0.991473078829136 0.14312205408422 no 512 0.160727315768566 688 27243542
SGTC_2397 5161689 200 µM 0.990174178792346 0.143432086702398 no 513 0.161044495564769 832 2259942
SGTC_603 3794-0023 45.9 µM 0.989791472037882 0.143523520854441 no 514 0.161138026993048 807 3802260
SGTC_435 c-PAF 6.7 µM 0.989150343229748 0.14367678390544 no 515 0.161294794759137 827 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2515 chrysin 20.77 µM 0.988069042336915 0.143935521061121 no 516 0.161559417986039 831 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1701 st028638 40.4 µM 0.986469004293145 0.144318959592694 no 517 0.161951509037596 840 3490878
SGTC_49 0717-0965 32.132 µM 0.983993703564257 0.144913504346916 no 518 0.1625593043835 845 5889349 YGL099W LSG1
SGTC_398 bronopol 33.3 µM 0.980444688280026 0.145768818992689 no 519 0.163433329954921 829 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2330 7979373 200 µM 0.979948647381141 0.145888634856769 no 520 0.163555733960313 812 1863007
SGTC_1037 k284-1091 78.7 µM 0.979595423374089 0.145973994443897 no 521 0.163642932473703 758 3334711
SGTC_778 3456-2434 196 µM 0.978316139316066 0.146283425138419 no 522 0.16395899501952 924 5539063
SGTC_2797 7859098 81.82 µM 0.976176596143909 0.146801917289578 no 523 0.164488479492597 812 972681
SGTC_3178 9107506 49.47 µM 0.97534946922647 0.147002691432476 no 524 0.164693469835037 816 8897194
SGTC_3296 9122258 64.045 µM 0.971673215183086 0.147897280815102 no 525 0.165606572991418 811 4730474
SGTC_1547 harmine 94.2 µM 0.97028430853375 0.148236207642277 no 526 0.16595239828566 902 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2384 9036245 200 µM 0.969704518470867 0.148377844059794 no 527 0.166096898784876 863 6462766
SGTC_112 phenothiazine 287.218 µM 0.96912327920848 0.148519925327632 no 528 0.166241842036214 887 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3349 9149703 23.001 µM 0.967250714964334 0.148978283542403 no 529 0.166709357511818 826 4910494
SGTC_751 0833-0568 350 µM 0.96676410509582 0.149097548347975 no 530 0.166830986157072 827 6954252
SGTC_181 1447-1644 8.07 µM 0.966310603709793 0.149208755883386 no 531 0.166944390826079 837 534600
SGTC_332 4112-0506 40.9 µM 0.965813863485452 0.149330629988206 no 532 0.167068665042719 840 2790355
SGTC_3087 9117406 49.47 µM 0.964246988253392 0.149715494674295 no 533 0.167461055816587 797 42546093
SGTC_2231 micatex 6.853 µM 0.962167170080366 0.150227372561798 no 534 0.167982818715033 845 20737 An antifungal of unknown mechanism.
SGTC_537 1334-0398 209 µM 0.960442762582741 0.150652661418578 no 535 0.1684162124481 878 5846986
SGTC_2336 9001819 198.65 µM 0.960404731438795 0.150662050028296 no 536 0.168425778877013 857 2989602
SGTC_2076 5212012 200 µM 0.957280229176998 0.151434715516484 no 537 0.169212915833084 756 604802
SGTC_3225 9130819 49.47 µM 0.956997812603198 0.151504684587247 no 538 0.1692841795349 855 4547121
SGTC_3103 9120822 49.47 µM 0.956122686354161 0.151721634718696 no 539 0.169505127201157 888 17141819
SGTC_2211 7117706 200 µM 0.955866607895233 0.151785157449389 no 540 0.169569815637718 816 822771
SGTC_1059 3448-6867 171 µM 0.955174270488771 0.151956986886023 no 541 0.169744787509544 870 3934407
SGTC_2832 7992762 51.95 µM 0.954801359411604 0.152049592247712 no 542 0.16983907990979 724 2985177
SGTC_2563 tomatine 8.54 µM 0.95437406604967 0.152155748483966 no 543 0.169947164420002 886 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1056 3448-1962 115 µM 0.952563244900986 0.152606172758295 no 544 0.170405703677939 810 715507
SGTC_1131 3454-3128 32.3 µM 0.951256071232285 0.152931868810976 no 545 0.170737200440044 896 710982
SGTC_1870 st057514 26.5 µM 0.950473324757 0.153127118774906 no 546 0.170935900904019 838 5393161
SGTC_551 k048-0028 34.9 µM 0.947582309687672 0.153849691211446 no 547 0.171671067759542 911 6836383
SGTC_3079 9117512 49.47 µM 0.945992695166349 0.154247955137138 no 548 0.172076156029922 933 7185044
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.945702861677178 0.154320643792225 no 549 0.17215008124974 848 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.942411840883832 0.155147602419083 no 550 0.172990913641401 884 94937 An inhibitor of serotonin biosynthesis.
SGTC_3343 9148379 18.9835 µM 0.941464412651759 0.155386210914419 no 551 0.173233459047579 894 1955036
SGTC_2593 nobiletin 86.24 µM 0.941210355475734 0.155450236016118 no 552 0.173298535500358 792 72344 An anti-infammatory.
SGTC_2737 bleomycin 30.5 nM 0.940264977826125 0.155688634078793 no 553 0.173540829596268 912 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_27 0485-0001 32.618 µM 0.939285671144021 0.155935842221383 no 554 0.173792046691343 793 2054479
SGTC_54 0159-0055 9 µM 0.93794080788627 0.156275749885078 no 555 0.17413741509048 875 3319099
SGTC_2150 5556613 200 µM 0.933092146707614 0.157505274482043 no 556 0.175386196778054 902 743190
SGTC_1221 2958-7315 257 µM 0.931928330709016 0.157801338708652 no 557 0.175686782604635 832 4562705
SGTC_1716 st033144 30.6155 µM 0.929164709470354 0.158505842411582 no 558 0.176401866700826 913 674617
SGTC_190 3970-0790 3.722 µM 0.928318691373639 0.158721921545656 no 559 0.176621140602283 857 2832352
SGTC_2569 tetrandrine 100 µM 0.928080216117481 0.15878286472222 no 560 0.176682980571759 779 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2128 5255449 168.493 µM 0.925549615673604 0.159430513305055 no 561 0.177340043876548 923 736008
SGTC_1616 st002734 56.1 µM 0.925076565843549 0.159551771045899 no 562 0.177463040885718 907 4026101
SGTC_2968 9090663 33.37 µM 0.924146620132922 0.159790321681533 no 563 0.17770499167887 853 25236811
SGTC_3098 9119039 49.47 µM 0.923373241809612 0.159988887113189 no 564 0.177906365625198 887 17161528
SGTC_605 1315-0399 119 µM 0.920441235746101 0.160743146627341 no 565 0.178671114158867 919 24020461
SGTC_794 k038-0031 316 µM 0.917527217081245 0.161495075778647 no 566 0.179433218745876 945 6624242
SGTC_76 0433-0009 400.328 µM 0.917137270686999 0.161595870685554 no 567 0.179535356406974 794 2841569
SGTC_1201 1889-3372 45.9 µM 0.917128027705363 0.161598260345945 no 568 0.179537777840765 866 5392199
SGTC_1529 apigenin 74 µM 0.916590417857851 0.161737292464329 no 569 0.179678653711643 896 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1923 st058458 19.1 µM 0.916171549945702 0.161845670560018 no 570 0.179788462441911 953 3534982
SGTC_373 0844-0104 25.9 µM 0.914511809276197 0.162275577810637 no 571 0.180223987746342 949 5375804
SGTC_2765 myclobutanil 7.74 µM 0.91251878940543 0.162792792709969 no 572 0.180747841541641 879 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1124 fisetin 1.16336 µM 0.910466809359319 0.163326427441672 no 573 0.181288188991102 854 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1243 0416-0003 5.65 µM 0.910216729907226 0.163391540315084 no 574 0.181354111442562 867 2141977
SGTC_826 1683-5028 118 µM 0.905572991499181 0.164603687651501 no 575 0.182580954810501 891 722377
SGTC_79 0052-0007 94.094 µM 0.903943677903161 0.165030362105079 no 576 0.183012633580205 913 2801472
SGTC_1184 1269-1718 139 µM 0.901885343873742 0.165570408538304 no 577 0.183558888819747 929 5403821
SGTC_2087 5276107 200 µM 0.901039780397413 0.165792590410807 no 578 0.183783584583646 900 144405
SGTC_2575 plumbagin 510 nM 0.89708024359104 0.166835568978262 no 579 0.184838050016006 878 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1064 honokiol 6.76 µM 0.89644082362631 0.167004394212443 no 580 0.185008686112196 906 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2425 5628681 7.85 µM 0.895622127238235 0.167220714350094 no 581 0.185227306877484 999 5714958
SGTC_65 0798-0905 34.986 µM 0.89277489393498 0.167974430505893 no 582 0.185988866862874 978 3602145
SGTC_57 miconazole 162.5 nM 0.891523319787089 0.16830643645841 no 583 0.18632424336758 882 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_185 k048-0037 25.491 µM 0.888584198737418 0.169087757339173 no 584 0.187113293136825 955 6827589
SGTC_2612 dictamnine 15.46 µM 0.884261157437943 0.170241197933693 no 585 0.188277625538406 885 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_3205 9113483 49.47 µM 0.882133759633995 0.170810660232875 no 586 0.188852238884758 925 17018033
SGTC_2486 5283202 22.39 µM 0.882054185961566 0.170831984154753 no 587 0.188873752798317 861 1377751
SGTC_1802 st050112 57.9 µM 0.881604379190703 0.170952554097325 no 588 0.188995393072344 970 4662563
SGTC_2130 NSC 7 2.4545 µM 0.881553004592457 0.170966328434574 no 589 0.189009289264049 973 21448
SGTC_1330 1469-0054 61.8 µM 0.881198172826712 0.171061483794319 no 590 0.189105284040621 986 7102664
SGTC_2939 9044578 71.43 µM 0.879070295970921 0.171632827775676 no 591 0.189681581107736 902 2653634
SGTC_953 1188-0045 9.7 µM 0.878653303958372 0.17174493460733 no 592 0.189794642334357 944 6144426
SGTC_1492 4158-0558 28.5 µM 0.877065793270131 0.172172159111691 no 593 0.19022545149644 933 3967268
SGTC_2320 7373003 200 µM 0.875200608401612 0.172674975919087 no 594 0.190732381124193 956 5415828
SGTC_3330 9141424 71.43 µM 0.874982228231211 0.172733908036772 no 595 0.190791787788632 986 27261020
SGTC_3210 9128157 49.47 µM 0.873007633903944 0.173267354415915 no 596 0.191329458391856 836 17590849
SGTC_1432 4049-0298 68.4 µM 0.872793746968046 0.173325199925482 no 597 0.191387754258753 943 741646
SGTC_487 nimodipine 119 µM 0.872042815252596 0.173528386009401 no 598 0.191592510326126 857 4497 L-type voltage-gated calcium channels inhibitor
SGTC_987 1497-1013 404 µM 0.870683455529022 0.173896585114341 no 599 0.19196350721166 954 1676435
SGTC_972 1319-0219 195 µM 0.869917553530971 0.174104257636802 no 600 0.192172730950148 906 23903702
SGTC_417 st075190 100 µM 0.866798601340616 0.174951581436428 no 601 0.193026184296994 982 222757
SGTC_1946 st076057 65.1 µM 0.865844539540616 0.175211292569276 no 602 0.193287710210666 846 953009
SGTC_1745 st081495 74 µM 0.86399564842926 0.175715286422985 no 603 0.193795140522811 977 13842402 YBL026W LSM2
SGTC_932 2857-0803 154 µM 0.862435715373319 0.176141226104643 no 604 0.19422389694219 1009 674898
SGTC_228 caffeine 993.056 µM 0.860613902279662 0.176639498716124 no 605 0.194725363250108 919 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_913 3487-1245 167 µM 0.859725248432431 0.176882871919282 no 606 0.194970256743591 918 4016153
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.858905975714855 0.177107431560179 no 607 0.195196196142257 916 279621
SGTC_3120 9124077 49.47 µM 0.857614480588425 0.177461791166706 no 608 0.195552688205935 1019 18774327 YGL155W CDC43
SGTC_2299 7976368 114.88 µM 0.857018330550753 0.177625513305957 no 609 0.195717377087825 958 2979718
SGTC_2058 5236698 133 µM 0.855882462383718 0.177937723272711 no 610 0.196031398242139 934 766665
SGTC_294 k038-0071 157 µM 0.855566325460862 0.178024679652288 no 611 0.196118851527256 967 24152826
SGTC_534 k292-0788 63.4 µM 0.854653612951247 0.178275879965818 no 612 0.196371468872233 1044 4146317
SGTC_2430 5571206 200 µM 0.85397847026827 0.17846183903416 no 613 0.196558459325389 1065 1731771
SGTC_2906 7926292 26.41 µM 0.850629923869224 0.17938595653623 no 614 0.197487480690698 984 2966319
SGTC_1279 0874-0590 65.2 µM 0.850581077905801 0.179399459061824 no 615 0.197501052141095 965 3523074
SGTC_1843 st055809 45.5 µM 0.849734206667902 0.179633661869344 no 616 0.197736437997991 917 16413835
SGTC_2327 6189656 200 µM 0.848914826856041 0.179860444693749 no 617 0.197964343965052 976 5349088
SGTC_619 1652-1634 108 µM 0.848595883400446 0.179948768472113 no 618 0.198053099205247 908 5400454
SGTC_3119 9125183 49.47 µM 0.847872950757723 0.180149068231954 no 619 0.198254365061445 845 22695334
SGTC_3255 9139072 49.47 µM 0.847335668192156 0.18029802136391 no 620 0.19840402551417 1010 17646060
SGTC_122 0236-0016 402.397 µM 0.847228527701635 0.180327733617889 no 621 0.198433877726699 1065 6808838
SGTC_3096 9117468 49.47 µM 0.845346815080406 0.180850071853237 no 622 0.198958614956923 884 41316311
SGTC_2358 9037157 4 µM 0.843165920287079 0.181456644262649 no 623 0.19956782769475 975 2388925
SGTC_459 nigericin 15.3 µM 0.843041402133611 0.181491314894645 no 624 0.199602644531732 1050 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1981 st071826 47 µM 0.841172287581064 0.182012246300281 no 625 0.200125711525897 921 11838600
SGTC_2871 9038510 12.99 µM 0.840335148804114 0.182245863818362 no 626 0.20036024959363 1037 4945164
SGTC_517 1365-0151 113 µM 0.83939328735148 0.182508929860139 no 627 0.200624324735087 946 768657
SGTC_111 0083-0039 52.457 µM 0.838350924651463 0.182800342684863 no 628 0.200916821466118 911 759313
SGTC_1629 st005085 44.9 µM 0.836029634112898 0.183450347645736 no 629 0.201569115996942 974 24207091
SGTC_631 k072-0230 41.5 µM 0.835873161465591 0.1834942146988 no 630 0.201613131209489 1014 5773147
SGTC_3291 9121177 71.43 µM 0.833111940221038 0.184269397537951 no 631 0.20239080006843 896 17015612
SGTC_727 3032-0951 202 µM 0.829230647746263 0.185362467903557 no 632 0.203486952899261 957 3652836
SGTC_44 0929-0055 61.211 µM 0.827466851315429 0.185860525254683 no 633 0.20398625155668 948 1379590
SGTC_841 0251-0215 91.2 µM 0.826705340235296 0.186075815524276 no 634 0.204202046900642 1043 3888614
SGTC_2678 equilin 100 µM 0.826146844580988 0.186233808598484 no 635 0.204360398560801 1041 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3224 9130643 49.47 µM 0.824420702749238 0.186722642885728 no 636 0.204850277753698 999 17644395
SGTC_3289 9119912 71.43 µM 0.823609305837708 0.186952700405443 no 637 0.205080793330567 999 17014829
SGTC_501 nsc-95397 161 µM 0.823245773015292 0.18705583069641 no 638 0.205184121971461 986 262093
SGTC_2337 9009472 200 µM 0.820303316605713 0.187891868089345 no 639 0.206021608077169 1014 5742383
SGTC_550 4123-0385 25.7 µM 0.817502742258614 0.188689732121712 no 640 0.206820591399551 1001 5731123
SGTC_2541 muurolladie-3-one 83.07 µM 0.816922233049467 0.188855376074448 no 641 0.206986435634195 967 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2034 5197015 53.07 µM 0.814811375181393 0.189458448467707 no 642 0.207590144336157 998 780676
SGTC_3260 9137109 49.47 µM 0.814276150265312 0.189611550443029 no 643 0.207743384709249 896 17478346
SGTC_2757 clomiphene 4.22 µM 0.813826301895812 0.189740289166873 no 644 0.207872232569948 1100 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.812668821724804 0.190071786750556 no 645 0.20820398078886 1058 6728940
SGTC_2505 galangin 7.89 µM 0.812398017925562 0.190149395199262 no 646 0.208281641599085 937 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1764 st044502 93.5 µM 0.810753265826349 0.190621175493472 no 647 0.208753688746578 1026 8407
SGTC_795 0685-0265 78 µM 0.810685178815587 0.190640721030486 no 648 0.208773243435403 1105 302754
SGTC_2860 9025725 38.96 µM 0.81052951117363 0.19068541270172 no 649 0.208817955464235 962 40546248
SGTC_132 0417-1715 25.805 µM 0.810349101494594 0.190737215774813 no 650 0.208869781144845 1056 6769098
SGTC_13 0199-0087 65 µM 0.809241871908158 0.191055336258837 no 651 0.20918801719084 1073 4589825
SGTC_3318 9139014 38.6185 µM 0.808970492640315 0.191133356433128 no 652 0.209266059602134 993 16643984
SGTC_2162 5663267 200 µM 0.808057632484746 0.191395942483829 no 653 0.209528702855086 1057 6456493
SGTC_1912 st060209 90.8 µM 0.808050390955315 0.191398026407679 no 654 0.209530787124214 989 688787
SGTC_1347 1493-0251 600 nM 0.807591575924956 0.191530089789349 no 655 0.209662868899165 1069 3986378
SGTC_1292 0kpi-0043 232 µM 0.806981202182604 0.191705863697066 no 656 0.209838656643008 980 3333905
SGTC_649 1123-0311 367 µM 0.806924147502444 0.191722299208673 no 657 0.20985509282734 1045 693629 YIL048W NEO1
SGTC_2778 tioconazole 65.09 nM 0.804961066579494 0.192288321493676 no 658 0.210421073587598 995 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_608 k048-0125 159 µM 0.804458640938883 0.192433351811848 no 659 0.210566073065076 1056 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1692 fluoroquinolonic acid 71 µM 0.801489786329876 0.19329170667339 no 660 0.211424077309481 1016 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1815 st051655 58.2 µM 0.800740251624733 0.193508780908544 no 661 0.211641017445035 1022 5984156
SGTC_1744 st037937 38.9 µM 0.800535561726384 0.193568087396338 no 662 0.211700284114419 1046 1016152
SGTC_1046 2001-0062 216 µM 0.80043697116872 0.19359665680474 no 663 0.21172883385439 987 739778
SGTC_1360 1598-0022 39.8 µM 0.800120937857954 0.193688253745908 no 664 0.211820365602376 1072 761525
SGTC_1569 carminic acid 40.6 µM 0.798434540418453 0.194177474256674 no 665 0.21230918290817 1065 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1193 1488-0126 41.5 µM 0.796376192562239 0.194775615729579 no 666 0.212906705845384 1105 1384710
SGTC_1209 2323-2347 50.3 µM 0.796092049423098 0.194858273682612 no 667 0.212989267488209 1063 5412760
SGTC_2106 5357045 167.29 µM 0.795271896236265 0.195096977934792 no 668 0.213227678873607 1037 668842
SGTC_820 1582-0060 59.9 µM 0.794444906834188 0.195337851743265 no 669 0.213468234990619 1017 3848840
SGTC_3258 9138477 49.47 µM 0.794227994019813 0.195401060945244 no 670 0.213531357142229 1096 4970355
SGTC_1884 5633444 25 µM 0.788935294952942 0.196947220677501 no 671 0.215074912790104 1048 5724239
SGTC_2481 5478948 45.16 µM 0.787354737382239 0.197410382255347 no 672 0.215537117598343 1034 77792
SGTC_2875 9039966 71.43 µM 0.786322078129423 0.197713344904815 no 673 0.2158394105733 1084 6463691
SGTC_3309 9129340 25.759 µM 0.786195188975313 0.197750591151863 no 674 0.215876572101955 1086 17158987
SGTC_2001 4023502 57.655 µM 0.781265164101922 0.199201000305802 no 675 0.21732327718569 1035 108941 YCR052W RSC6
SGTC_386 1509-0011 3.07 µM 0.780328795097668 0.199477201587306 no 676 0.217598683943721 1125 3107280
SGTC_345 1362-0200 395 µM 0.77987458829286 0.199611262209379 no 677 0.217732348687156 1034 1419823
SGTC_1875 nocodazole 6 µM 0.77984845136501 0.199618978258355 no 678 0.217740041747329 1074 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_763 3453-1109 128 µM 0.778436328261651 0.200036126872811 no 679 0.218155914612207 1097 1560353
SGTC_3141 9094609 49.47 µM 0.778380325029054 0.200052681320184 no 680 0.218172417099578 995 25236309 YDL196W YDL196W
SGTC_783 0848-0141 92.7 µM 0.778091202973195 0.20013815834203 no 681 0.21825762421552 1003 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3059 1327-0034 3 µM 0.77802987134745 0.200156293452981 no 682 0.218275701714135 1038 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1381 2324-0066 62.1 µM 0.776872787966295 0.200498615782497 no 683 0.218616913702544 1025 10885928
SGTC_310 1273-0058 1.06 µM 0.775169428687645 0.201003192779722 no 684 0.219119775142526 1139 2734232
SGTC_3113 9123498 49.47 µM 0.773438591704849 0.201516688837792 no 685 0.219631429053979 1148 8897275
SGTC_1567 st069303 68.4 µM 0.771645402046788 0.202049511523358 no 686 0.220162237964491 1085 5581319
SGTC_621 3584-0052 32.1 µM 0.771181010697274 0.202187636620566 no 687 0.220299824066574 1114 2273927
SGTC_45 0kpi-0036 14.9 µM 0.771126696258687 0.202203795191009 no 688 0.220315919127167 1051 2795021
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.769547176059769 0.202674041014969 no 689 0.220784274960784 1110 688664
SGTC_2908 7930301 100 µM 0.767992670057618 0.203137477270612 no 690 0.221245769822014 1087 2223178
SGTC_335 4077-0256 27.6 µM 0.766760580277788 0.20350524238496 no 691 0.221611938835774 1142 3121989
SGTC_743 1275-0778 158 µM 0.760685589476076 0.20532435830499 no 692 0.223422442050637 1094 2849257 YMR203W TOM40
SGTC_1126 isoteolin 1.0172 µM 0.760183672671552 0.205475084737278 no 693 0.223572401575917 1110 133323
SGTC_123 0083-0120 66.675 µM 0.759061748351585 0.205812237913796 no 694 0.223907809926427 1070 16001701
SGTC_1246 0422-0085 105 µM 0.758938363036256 0.205849336865882 no 695 0.223944714409201 1110 264295
SGTC_2567 aureobasidin a 60 nM 0.757444285557861 0.20629888430275 no 696 0.224391866421556 1087 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2629 bisabolol 100 µM 0.757344389931055 0.206328962265924 no 697 0.224421781548914 1097 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2073 5212005 126 µM 0.753740185032585 0.20741590380967 no 698 0.225502623532282 988 691789
SGTC_175 3793-3120 23.7 µM 0.753606607408357 0.207456252552556 no 699 0.225542737814508 1100 5322297
SGTC_749 1000-0129 128 µM 0.752901804349593 0.207669223681582 no 700 0.225754461895668 1152 708470
SGTC_445 e6 berbamine 66 µM 0.752341331784113 0.207838674467155 no 701 0.225922909061304 1155 6610268 A calcium/calmodulin antagonist.
SGTC_3268 9137683 49.47 µM 0.752171107852602 0.207890155376022 no 702 0.22597408306028 1092 1953228
SGTC_1786 berberine 21.6 µM 0.75194600626669 0.207958244522527 no 703 0.226041764854312 1073 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2341 7987486 176.74 µM 0.750250050043959 0.20847166366073 no 704 0.226552060009798 1139 1258686
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.749986855975966 0.208551407707637 no 705 0.226631310554024 1100 75037 A free radical scavenger.
SGTC_2307 7538926 6.34 µM 0.747434057374246 0.209325801977783 no 706 0.227400796893557 1120 96582
SGTC_3012 9080433 71.4286 µM 0.7472368874201 0.209385684020438 no 707 0.2274602907099 1141 17688859
SGTC_1207 2099-0101 141 µM 0.747011002682802 0.209454299353113 no 708 0.227528459663026 1156 5837381
SGTC_1491 4138-0063 26.5 µM 0.744488872451364 0.210221326227329 no 709 0.22829038534279 1095 23883227
SGTC_2921 7974240 10.71 µM 0.74357614434833 0.210499309880793 no 710 0.22856646993014 1110 2979074 YDR527W RBA50
SGTC_1307 1187-1599 12.2 µM 0.742950745757091 0.210689907952971 no 711 0.228755750493692 1131 1538471
SGTC_2751 anetholtrithion 17.25 µM 0.739752241239239 0.211666274131588 no 712 0.229725171408061 1088 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2199 6590217 200 µM 0.739059615007904 0.211878051502555 no 713 0.229935399143886 1085 703109
SGTC_1773 st048542 73.5835 µM 0.738921747464303 0.211920220665503 no 714 0.22997725791034 1096 3237138
SGTC_464 bw-b 70c 158 µM 0.736007822368187 0.212812642691732 no 715 0.230862968662534 1159 5353454
SGTC_2196 6573537 42.6665 µM 0.734730819153748 0.213204429473894 no 716 0.231251723454432 1154 2903087
SGTC_2322 7413319 38.22 µM 0.733723876293224 0.213513657672417 no 717 0.23155852180618 1147 1840400
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.732861621234389 0.213778660426982 no 718 0.231821416472482 1103 521171
SGTC_655 k060-0012 42 µM 0.731238910955945 0.214277898220911 no 719 0.232316618423647 1126 5994525
SGTC_2241 6772625 37.8075 µM 0.727858462535633 0.215320091291332 no 720 0.233350116222496 1125 2285411
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.72781002924233 0.215335044628684 no 721 0.233364942151053 1164 688761
SGTC_1033 k072-0102 21.3 µM 0.727362120300263 0.215473360977644 no 722 0.23350207644208 1140 5965931
SGTC_135 0933-0004 26.348 µM 0.727279711843726 0.21549881470127 no 723 0.23352731194045 1094 21230617 YGL099W LSG1
SGTC_1255 0566-0045 221 µM 0.726451337884395 0.215754773672779 no 724 0.233781064445346 1139 2788469
SGTC_372 0155-0182 15.9 µM 0.726412046508897 0.215766918676737 no 725 0.233793104211375 1157 771486
SGTC_641 4092-0595 30 µM 0.725847850403373 0.21594135595803 no 726 0.233966024547808 1153 786260
SGTC_3104 9120930 49.47 µM 0.72495709107963 0.216216925823354 no 727 0.234239177349177 1133 17014836
SGTC_1968 st069590 43.6 µM 0.724523872995206 0.216351021950549 no 728 0.234372088164301 1118 6384066
SGTC_153 4077-0274 519.67 µM 0.72302493541787 0.216815366745093 no 729 0.234832282368068 1194 3121976
SGTC_3266 9136860 49.47 µM 0.722283537114529 0.217045251870564 no 730 0.235060086203 1113 4871271 YPR165W RHO1
SGTC_2864 9034755 47.6 µM 0.721523661368255 0.217281012384506 no 731 0.235293694082272 1168 4930451
SGTC_1409 3909-8004 61.9 µM 0.721066594333913 0.217422894092046 no 732 0.235434271477874 1167 2119279
SGTC_518 1021-0119 62.6 µM 0.721062790889664 0.217424074972904 no 733 0.235435441475078 1093 1097762
SGTC_328 k915-0120 63.5 µM 0.720216850027526 0.217686811893671 no 734 0.235695745436692 1137 6624543
SGTC_408 cantharidin 100 µM 0.719899993518666 0.217785270051453 no 735 0.235793286008968 1115 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_898 1000-0849 28.3 µM 0.718413306422688 0.218247577474785 no 736 0.236251242314445 1163 6751807
SGTC_770 0389-1121 67.2 µM 0.717381777925271 0.21856867858394 no 737 0.236569280025531 1205 6753108
SGTC_3053 9095903 49.47 µM 0.717173534205836 0.218633535067716 no 738 0.236633513659672 1210 17174018
SGTC_2945 9067681 61.76 µM 0.71682427538194 0.218742334880937 no 739 0.236741265522007 1226 16456930
SGTC_1964 st076914 61 µM 0.716059846916244 0.218980575502852 no 740 0.236977197914711 1188 24208661
SGTC_1603 st002045 67.8 µM 0.71096199308261 0.220573176486509 no 741 0.238553894127032 1181 5887985
SGTC_947 3447-0010 211 µM 0.710043467170121 0.220860833585707 no 742 0.238838590854809 1192 748350
SGTC_278 4092-0821 23.9 µM 0.709949373900318 0.220890313137954 no 743 0.238867765514984 1176 877900
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.708826172622751 0.221242387558674 no 744 0.23921617696359 1168 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2111 5486399 200 µM 0.708819032496437 0.221244626701905 no 745 0.239218392683116 1194 689674
SGTC_2050 5263056 171 µM 0.703678545703369 0.222860043870528 no 746 0.240816492039228 1200 763468 YGL055W OLE1
SGTC_1269 0831-0796 3.05 µM 0.702969461696323 0.223083402385753 no 747 0.241037390498427 1173 927758
SGTC_1233 0325-0408 14.2 µM 0.698397392821158 0.224526642187466 no 748 0.242464353200972 1189 12874
SGTC_1449 4112-4002 201 µM 0.698362190126477 0.224537774941565 no 749 0.242475357840216 1169 2059539
SGTC_1573 oleylamine 1.06 µM 0.697030680466382 0.224959091055601 no 750 0.242891796814791 1211 5356789 An amine of the fatty acid oleic acid.
SGTC_3018 9082602 49.47 µM 0.696921409653854 0.224993686394898 no 751 0.242925989200608 1199 17332089
SGTC_401 neomycin 50 µM 0.696380337192436 0.225165035349506 no 752 0.243095336807911 1146 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2816 7982706 58.44 µM 0.695524994412381 0.22543605940518 no 753 0.243363176515482 1192 2981853
SGTC_3102 9121669 49.47 µM 0.695065888076351 0.225581608047943 no 754 0.243507005565124 1202 41905072
SGTC_1940 st075990 51.1 µM 0.693989702028613 0.225922995345069 no 755 0.243844333529564 1295 1084979
SGTC_2827 7993847 71.43 µM 0.693883996890742 0.225956542833912 no 756 0.243877480150894 1142 2985692
SGTC_2863 9028737 58.44 µM 0.693589790432595 0.226049929544694 no 757 0.243969749110464 1176 6460917
SGTC_3248 9135562 49.47 µM 0.692422472835512 0.226420673218535 no 758 0.244336028511004 1241 17650701
SGTC_2716 st080858 38.6235 µM 0.691450821362521 0.226729534419584 no 759 0.24464113792838 1189 5296050
SGTC_3342 9147791 14.508 µM 0.690904859235736 0.226903184990154 no 760 0.244812666125078 1171 1838168
SGTC_2407 paclitaxel 400 µM 0.690590301691855 0.227003268283564 no 761 0.244911521940978 1224 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1955 wogonin 32.4 µM 0.690544748372754 0.227017764121594 no 762 0.244925839736443 1251 5281703 A flavanone.
SGTC_2654 protoveratrine a 100 µM 0.689747098699611 0.227271674336834 no 763 0.245176620787022 1186 5702278 A heart drug and vasodilator.
SGTC_1286 0929-0070 131 µM 0.689424168133985 0.227374516046584 no 764 0.24527818940656 1253 1420408
SGTC_1635 st007035 42.4 µM 0.687349979111678 0.228035694903916 no 765 0.245931105426552 1223 3716403
SGTC_2475 5812728 15.03 µM 0.685744010386455 0.228548363402425 no 766 0.246437274344033 1222 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1699 st031318 29.054 µM 0.685681601713389 0.228568298992388 no 767 0.246456955560414 1241 5340658
SGTC_2153 5569715 200 µM 0.683885605552476 0.229142423526758 no 768 0.247023702117653 1212 2054701
SGTC_1982 st072467 71.9 µM 0.682186045664427 0.229686464399984 no 769 0.247560658593254 1192 3163533
SGTC_2208 7283366 200 µM 0.680314867723028 0.230286277225241 no 770 0.248152556238246 1226 898663
SGTC_1553 gossypol 38.6 µM 0.679758878353527 0.230464670283082 no 771 0.248328574114586 1149 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2979 9012552 45.46 µM 0.679608055688333 0.230513076100947 no 772 0.248376333777091 1273 17100905
SGTC_1814 st052110 31.539 µM 0.678709827438297 0.230801475854667 no 773 0.248660869049641 1210 674163
SGTC_199 4063-0024 41.6 µM 0.678205593995723 0.230963461509731 no 774 0.248820673098333 1242 306215
SGTC_1751 st044839 27.194 µM 0.677684277824563 0.231131001723377 no 775 0.248985948553091 1224 5291326
SGTC_692 k241-0027 77.8 µM 0.675521232498148 0.231826883653819 no 776 0.249672333143483 1271 3600480
SGTC_2345 9052315 157.45 µM 0.67476531250996 0.232070348601058 no 777 0.249912440890736 1228 6469265
SGTC_1631 benzylvanillin 81.9 µM 0.674759531798694 0.232072210987313 no 778 0.249914277527467 1235 75506
SGTC_1077 5-fluorocytosine 377 nM 0.6731296340407 0.232597651010061 no 779 0.250432411230353 1217 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1647 st011722 22.4 µM 0.672528689403519 0.232791547926747 no 780 0.250623591103782 1233 2854783
SGTC_740 k014-0057 261 µM 0.672442860593466 0.232819248224424 no 781 0.250650902324675 1238 4012779
SGTC_931 2812-0076 566 µM 0.671961604871847 0.232974602096737 no 782 0.250804069858596 1258 3450959
SGTC_866 0495-0101 262 µM 0.670739276557854 0.233369439871579 no 783 0.251193318569323 1205 635694
SGTC_787 4152-0075 138 µM 0.669164420178476 0.233878698504326 no 784 0.251695299950481 1250 9566539
SGTC_1527 coumarin 137 µM 0.669128367614191 0.233890363966082 no 785 0.251706797811401 1270 323 A hepatotoxic, DNA x-linker.
SGTC_1157 4092-0394 27.6 µM 0.667769394747641 0.234330319350451 no 786 0.252140402784358 1328 3659885
SGTC_384 k007-0144 5.16 µM 0.667745722499232 0.234337987086975 no 787 0.252147959334813 1240 6824886
SGTC_1922 5578187 25 µM 0.667706167034883 0.234350799905123 no 788 0.252160586321774 1281 1350412
SGTC_1019 4262-0212 3.4 µM 0.666672864920934 0.234685644759619 no 789 0.252490557531051 1289 4677213
SGTC_2080 5212524 12.4 µM 0.665664379329959 0.235012702672909 no 790 0.252812823178139 1217 260183
SGTC_2254 7938975 95.19 µM 0.665502513960045 0.235065220023088 no 791 0.252864568071267 1303 2969277
SGTC_2525 harmine 47.85 µM 0.665162864845011 0.235175440524099 no 792 0.252973164740875 1209 5280953 A monoamine oxidase inhibitor
SGTC_2978 9011784 42.97 µM 0.664847728759394 0.235277731752377 no 793 0.253073945756965 1304 2994934
SGTC_430 0958-0115 16.4 µM 0.66329911009671 0.23578076058862 no 794 0.253569503204193 1247 6833180
SGTC_691 1548-0686 185 µM 0.662231866144395 0.236127772124356 no 795 0.253911317383171 1216 46495133
SGTC_3033 9090887 49.47 µM 0.661314348329969 0.236426325367495 no 796 0.25420537085282 1241 19325384
SGTC_2940 9060638 45.86 µM 0.661062171346122 0.236508418206713 no 797 0.254286221829466 1241 4027022
SGTC_1150 3909-7983 10.9 µM 0.659511067993485 0.237013703948654 no 798 0.254783820563503 1238 23965914
SGTC_847 0342-0274 5.54 µM 0.658442056862134 0.237362288913602 no 799 0.255127059121155 1260 18097
SGTC_489 paxilline 115 µM 0.656912095399273 0.237861670721316 no 800 0.255618720226861 1227 105008 A toxic potassium channel blocker.
SGTC_1013 4112-3890 241 µM 0.656278571387138 0.23806862250074 no 801 0.255822451257032 1219 705171
SGTC_223 busulfan 5 mM 0.656087362749316 0.238131103552632 no 802 0.255883957494953 1254 2478 A DNA alkylator.
SGTC_3115 9123671 49.47 µM 0.655545747102406 0.238308135512443 no 803 0.25605822132131 1328 3286988
SGTC_665 3914-0008 307 µM 0.655496748960554 0.238324154552012 no 804 0.256073989435149 1234 1069549
SGTC_786 4544-0069 423 µM 0.654314555969248 0.238710829485397 no 805 0.256454584956167 1284 748821 YLR208W SEC13
SGTC_1389 3405-0187 19 µM 0.65406563167008 0.238792292055847 no 806 0.256534761255906 1219 799890
SGTC_1681 tripelennamine 100 µM 0.653534049234416 0.23896630778126 no 807 0.256706022927506 1260 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1075 aripiprazole 15.2 µM 0.651137511029648 0.239751684800367 no 808 0.257478862049007 1288 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2374 9071832 200 µM 0.650348057556219 0.24001070711514 no 809 0.257733710552952 1236 17381698
SGTC_2279 7948423 32.93 µM 0.649755991075167 0.240205066185739 no 810 0.25792492519336 1291 1247112
SGTC_873 0591-4978 488 µM 0.648976509829853 0.240461079091627 no 811 0.258176779763136 1375 3305145
SGTC_1027 k015-0025 8.67 µM 0.648354603522985 0.240665444598294 no 812 0.258377812427594 1247 3598955
SGTC_1256 0570-0116 285 µM 0.647863379938541 0.240826933076899 no 813 0.258536658910262 1252 410638
SGTC_2412 st077135 33.4 µM 0.646354058087414 0.241323487380546 no 814 0.259025043059982 1341 13258915
SGTC_1203 3992-3522 103 µM 0.646242021646411 0.241360368602279 no 815 0.259061314660232 1467 5322312
SGTC_3221 9128209 49.47 µM 0.64621730323877 0.241368506055247 no 816 0.259069317554768 1299 16460723
SGTC_1930 st074634 34.3 µM 0.646150036028452 0.241390651592436 no 817 0.259091096805178 1252 684253 YOR116C RPO31
SGTC_3192 9110362 49.47 µM 0.645027793341893 0.24176027620322 no 818 0.259454587345835 1338 16649480
SGTC_1397 3532-0190 20.1 µM 0.643919697187458 0.24212554265376 no 819 0.259813754136388 1221 5322280
SGTC_113 0099-0221 2.5 µM 0.643452849868518 0.242279521061055 no 820 0.259965149954044 1334 89219
SGTC_2181 6316240 54.2555 µM 0.643327985981153 0.242320713417365 no 821 0.260005650282917 1264 12779990
SGTC_527 4476-4215 268 µM 0.641993571824269 0.242761170998283 no 822 0.260438678384488 1284 4418754
SGTC_1048 3161-0300 24.5 µM 0.641890491731133 0.242795213244742 no 823 0.26047214414928 1284 2165101
SGTC_2779 methotrexate 400 µM 0.640667020571277 0.243199462384631 no 824 0.260869522765434 1325 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.640177640301981 0.243361261157769 no 825 0.261028558816747 1375 5282309
SGTC_192 3455-0609 60.9 µM 0.637974028096263 0.244090538967338 no 826 0.26174529339674 1315 3769639
SGTC_845 0330-0138 4.51 µM 0.63767821315046 0.244188527549373 no 827 0.261841585321503 1276 9039800
SGTC_690 glyoxal 20.3 µM 0.637470819489786 0.244257239261723 no 828 0.261909105707255 1183 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_156 3474-0145 5.642 µM 0.635916062301982 0.244772678544143 no 829 0.262415566443618 1238 2265471
SGTC_1826 st055655 41.6 µM 0.635895930290154 0.244779356626576 no 830 0.262422127715215 1323 676168
SGTC_3025 9087895 49.47 µM 0.634693076560596 0.245178538717555 no 831 0.262814305001435 1288 17173641
SGTC_1908 st060353 56.5 µM 0.63375112191284 0.24549138240659 no 832 0.263121628132397 1337 4227716
SGTC_2695 st077686 51.995 µM 0.633678429459338 0.24551553406731 no 833 0.263145352479721 1268 2876092
SGTC_3106 9121286 49.47 µM 0.631819041883022 0.246133738871753 no 834 0.263752564700067 1315 15943471
SGTC_1114 scopoletin 1.73284 µM 0.630166239314131 0.246683958886245 no 835 0.264292912601853 1325 5280460 A coumarin with genotoxic properties.
SGTC_959 1222-0044 107 µM 0.628871105497591 0.247115570397596 no 836 0.264716722010887 1276 6083612
SGTC_508 roscovitine 141 µM 0.628377437604082 0.247280194600384 no 837 0.264878356934471 1353 160355 A CDKinase inhibitor.
SGTC_2165 5727197 32.143 µM 0.627454832881031 0.247588014156341 no 838 0.265180567194159 1418 1361712
SGTC_2826 7992541 19.48 µM 0.627429394621353 0.247596504323364 no 839 0.265188902281467 1360 2985066
SGTC_3022 9087993 49.47 µM 0.627179633223948 0.247679871900382 no 840 0.265270746039542 1325 17173644
SGTC_1237 0330-0133 46.1 µM 0.627108571397646 0.247703594286895 no 841 0.265294034474771 1262 X1237 YHR072W ERG7
SGTC_591 4299-0174 154 µM 0.626929691738798 0.247763314593773 no 842 0.265352661645481 1289 5509088
SGTC_834 0312-0008 75.7 µM 0.626633191648671 0.2478623202877 no 843 0.265449852974431 1313 6385573 YIL048W NEO1
SGTC_1614 st002383 48.6 µM 0.626333121233067 0.247962539662155 no 844 0.265548233026207 1308 1947235
SGTC_1416 3966-0321 25.3 µM 0.625336965686158 0.248295396847863 no 845 0.265874961708201 1305 582530 YLR208W SEC13
SGTC_2295 7971645 200 µM 0.625305663948746 0.248305859925029 no 846 0.265885231653502 1332 2978226 YKL099C UTP11
SGTC_53 0973-0023 39.979 µM 0.624520717062962 0.248568317082893 no 847 0.266142834554907 1290 674768
SGTC_52 0329-0193 875 nM 0.62379422776437 0.248811359818505 no 848 0.266381365471441 1372 3739292
SGTC_985 1493-0307 8.71 µM 0.623790479487571 0.248812614110511 no 849 0.266382596437446 1278 3278274
SGTC_2246 7293507 91.5585 µM 0.622762494656071 0.24915673738383 no 850 0.266720304006524 1336 887656
SGTC_2192 5915882 198.485 µM 0.622746096307481 0.249162228866914 no 851 0.266725692849198 1260 2876149
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.622570875002593 0.249220911040095 no 852 0.266783277695352 1290 4174840
SGTC_952 1185-0122 232 µM 0.622090566108002 0.249381805697083 no 853 0.266941158938592 1248 678600
SGTC_1427 4048-4900 550 nM 0.621565482746248 0.249557762131325 no 854 0.267113811877847 1320 24132586
SGTC_547 1120-0019 610 nM 0.620884507963881 0.249786056280238 no 855 0.267337807494393 1309 3676939
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.620294741169398 0.249983862871348 no 856 0.267531878269369 1315 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1098 clofazimine 15.1 µM 0.619762538933949 0.250162433750228 no 857 0.267707067596985 1357 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2814 7977482 42.97 µM 0.619513188797844 0.250246121968459 no 858 0.267789168088388 1364 6456762
SGTC_2798 7813637 45.45 µM 0.618591607898009 0.250555556634368 no 859 0.268092715882245 1315 956368
SGTC_1198 1612-1005 86.7 µM 0.61783285969902 0.250810469842208 no 860 0.26834276021613 1387 6998509
SGTC_731 3966-0296 387 µM 0.616953219171451 0.251106170476933 no 861 0.268632791182217 1338 660956
SGTC_1322 1348-1070 12 µM 0.615263913608267 0.251674565492032 no 862 0.269190222514161 1289 6758089
SGTC_218 alverine citrate 93.75 µM 0.615220608960484 0.251689144990186 no 863 0.269204519659849 1336 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2753 fluvastatin 17.09 µM 0.613498021140243 0.252269455083091 no 864 0.269773545411929 1347 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_965 1291-5240 308 µM 0.613057469654657 0.252417982476321 no 865 0.26991917028951 1354 2834598
SGTC_2388 9080168 200 µM 0.610708525110065 0.253210682256595 no 866 0.270696280590662 1270 15943073
SGTC_180 1486-1293 102.781 µM 0.610575750200203 0.253255528945728 no 867 0.270740240358294 1397 4140536
SGTC_2163 5671233 125 µM 0.610321703874647 0.253341348487538 no 868 0.270824361193153 1410 701023
SGTC_1828 st055811 49 µM 0.609539195609414 0.253605784106472 no 869 0.271083550409229 1291 5877589
SGTC_1421 4029-0249 71.4 µM 0.608482301839267 0.253963173754673 no 870 0.271433820263996 1418 2894095
SGTC_1646 st011709 75.6 µM 0.60813390696557 0.254081041709418 no 871 0.271549332749035 1309 5757843
SGTC_1760 st045453 10.4495 µM 0.606419218424898 0.254661568125964 no 872 0.272118204896419 1341 3323419 YIL048W NEO1
SGTC_593 1203-0218 61.7 µM 0.60625630458166 0.254716760487558 no 873 0.272172284668516 1370 3666956
SGTC_2999 9069765 71.4286 µM 0.606114196620981 0.254764909294057 no 874 0.272219462223168 1348 2097066
SGTC_3076 9116187 49.47 µM 0.605070960483837 0.255118522839122 no 875 0.272565924202107 1334 27241210
SGTC_1522 st012842 45.6 µM 0.604660249365576 0.255257807172331 no 876 0.272702382676906 1262 3491067 YOR116C RPO31
SGTC_2958 9077254 16.72 µM 0.604266046453254 0.255391530464855 no 877 0.272833388188653 1348 16457351
SGTC_504 lovastatin 124 µM 0.603325346547735 0.255710786800524 no 878 0.273146137203806 1289 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2991 9074669 71.4286 µM 0.600805999182212 0.256566832433615 no 879 0.273984603953529 1395 17333109
SGTC_3176 9106582 49.47 µM 0.600699738014711 0.256602971550044 no 880 0.274019996787523 1260 17018027
SGTC_824 1304-0008 100 µM 0.600359959266077 0.25671854711101 no 881 0.274133183421076 1344 768245
SGTC_3090 9117696 49.47 µM 0.600025261369788 0.256832420913748 no 882 0.274244700103951 1376 7923821
SGTC_676 falcarinol 140 µM 0.599873654966807 0.256884010400277 no 883 0.274295220619301 1430 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1929 genistein trimethyl ether 50.5 µM 0.599396480861106 0.257046421100499 no 884 0.274454261579307 1355 136420
SGTC_1314 1222-0010 41.1 µM 0.599091703458397 0.257150182902629 no 885 0.274555866951157 1342 3526027
SGTC_3339 9145883 14.936 µM 0.598893619064182 0.257217632628231 no 886 0.274621913417838 1290 2030670
SGTC_2016 5121758 140 µM 0.598684777556805 0.257288755217935 no 887 0.274691555070073 1311 2795203
SGTC_1787 fluconazole 80 µM 0.59829478579546 0.257421597288381 no 888 0.274821627580501 1253 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1000 4048-0884 8.67 µM 0.596932811507304 0.257885803102901 no 889 0.275276119847635 1349 13040088
SGTC_2164 5685496 200 µM 0.595493455223714 0.258376854898991 no 890 0.275756836313526 1342 759046
SGTC_1074 carmofur 3.8 µM 0.593477224698685 0.259065527253693 no 891 0.276430910327531 1374 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2294 7971431 200 µM 0.590214613195874 0.26018192610838 no 892 0.277523388132444 1345 5741572
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.589495762917101 0.260428234883587 no 893 0.277764376817398 1331 17037758
SGTC_2839 9003951 25.97 µM 0.588734629510653 0.260689162498 no 894 0.278019651905473 1362 2990634
SGTC_1511 0906-3109 28.5 µM 0.588413685524687 0.260799227082446 no 895 0.278127326999469 1365 2882180
SGTC_1106 tegaserod maleate 11.7 µM 0.58828791814431 0.260842364288004 no 896 0.278169526869724 1384 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1703 st026983 48.3 µM 0.586691761586601 0.261390151925724 no 897 0.278705370888144 1397 1104023
SGTC_2096 5468907 200 µM 0.586674812649994 0.261395971828155 no 898 0.278711063492904 1375 759785
SGTC_2025 5147754 141 µM 0.585456076260453 0.261814634215226 no 899 0.27912054630449 1367 315777 YLR208W SEC13
SGTC_226 1,3-diallylurea 8.28947 mM 0.585322573693188 0.261860516136138 no 900 0.279165419554252 1324 74537 YKL182W FAS1
SGTC_411 enrofloxacin 100 µM 0.582236562473869 0.26292225908444 no 901 0.280203674433125 1480 71188 A bacterial gyrase inhibitor.
SGTC_2134 5324836 1.464 µM 0.582138505610285 0.262956031615713 no 902 0.280236695239374 1394 699272
SGTC_450 aminopyrene 156 nM 0.581711938572858 0.263102974708108 no 903 0.280380364307196 1374 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1410 3909-8106 77.9 µM 0.579781733576061 0.263768412547557 no 904 0.281030908617105 1404 1039210
SGTC_2032 5185112 25.99 µM 0.577276228897587 0.264633463150864 no 905 0.281876434570168 1311 5718189
SGTC_509 pifithrin 175 µM 0.575571115586694 0.265222994704759 no 906 0.28245255464744 1458 4817 A p53 inhibitor.
SGTC_3164 9100705 49.47 µM 0.574422742008439 0.265620412655924 no 907 0.282840883537939 1421 17174235
SGTC_2207 7258803 200 µM 0.572765479485576 0.266194473856712 no 908 0.283401747691437 1362 3666799
SGTC_735 3076-0345 636 µM 0.571040641426368 0.266792608947477 no 909 0.283986046946383 1462 2888990
SGTC_2601 securinine 100 µM 0.570898084853254 0.266842074734323 no 910 0.284034364618913 1342 442872 A GABA receptor antagonist.
SGTC_346 4513-0042 7.16 µM 0.570530247803971 0.266969732123917 no 911 0.28415905630416 1380 2827372
SGTC_1621 st003705 32.4 µM 0.568659565738034 0.267619426966733 no 912 0.284793596460853 1428 24207032
SGTC_623 k072-0108 16.9 µM 0.568420211482891 0.26770261306542 no 913 0.284874834805165 1386 5382803
SGTC_1977 st070720 65.3 µM 0.568372539141649 0.267719182850307 no 914 0.284891016418665 1377 682188
SGTC_1948 st076329 66.6 µM 0.56661929803398 0.268328927030047 no 915 0.285486430433396 1308 24208413
SGTC_187 1488-2104 32.728 µM 0.565210122235508 0.268819517618653 no 916 0.285965426292909 1442 2852859
SGTC_3061 glucosamine 200 µM 0.564722442906525 0.268989403209132 no 917 0.286131283312087 1353 91431 and experimental redox chemotherapeutic
SGTC_2881 9058953 51.95 µM 0.563378361637499 0.269457899577034 no 918 0.286588634232504 1332 17122249
SGTC_383 2324-0395 7.37 µM 0.563211002805519 0.269516263216648 no 919 0.286645605736803 1445 3146421
SGTC_2084 5306078 60.6385 µM 0.562904717654089 0.269623091528943 no 920 0.286749883790282 1392 679340
SGTC_3239 9133757 49.47 µM 0.561653157087415 0.270059840054711 no 921 0.287176177737569 1447 17036923
SGTC_2048 5246248 200 µM 0.560481310967001 0.270469091787115 no 922 0.287575591896949 1402 677046
SGTC_2158 5657123 3.6195 µM 0.55882760753786 0.271047152552072 no 923 0.288139689553222 1392 2858827
SGTC_687 k029-0044 34.9 µM 0.556940599181568 0.271707518201697 no 924 0.28878400730121 1459 5829338
SGTC_809 3998-0021 90 µM 0.555763791712231 0.272119751455468 no 925 0.289186170535115 1366 715485
SGTC_2982 9019404 25.97 µM 0.554551257938101 0.272544824537225 no 926 0.289600818118628 1245 22333232
SGTC_1606 st000094 49.2 µM 0.553388968490012 0.272952592881222 no 927 0.289998545574212 1439 1242210
SGTC_1888 azatryptophan 97.5 µM 0.552836098348126 0.273146663538252 no 928 0.2901878237703 1388 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1887 st057648 70.8 µM 0.552285129542808 0.273340134781001 no 929 0.290376508596123 1480 688672
SGTC_3064 1327-0027 10 µM 0.550625466840231 0.2739233307584 no 930 0.290945223683449 1328 16000455 YPR107C YTH1
SGTC_893 0958-0369 48.9 µM 0.548679104592259 0.27460805404369 no 931 0.291612844207599 1497 6819948
SGTC_1489 4065-0444 182 µM 0.547233907428176 0.275117014826944 no 932 0.292109021981004 1451 2877968
SGTC_1089 terbinafine 2.25 µM 0.547122680724843 0.275156205217717 no 933 0.292147225587214 1452 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2517 totarol 10 µM 0.545864488549095 0.275599716735048 no 934 0.2925795451269 1356 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_967 1306-0166 352 µM 0.544551762100369 0.276062825914999 no 935 0.293030919449262 1458 4437607
SGTC_1889 st059080 5.18 µM 0.544507221619114 0.276078545793561 no 936 0.293046240132327 1481 176925 Isolated from Daphnopsis sellowiana.
SGTC_128 0906-2981 13.371 µM 0.542585010856906 0.276757378984535 no 937 0.293707780766746 1465 6740226
SGTC_802 4112-3352 742 µM 0.542351487164973 0.27683990409011 no 938 0.293788196440224 1512 704594
SGTC_1278 0874-0585 172 µM 0.54231432593117 0.27685303763674 no 939 0.293800994135419 1424 766306
SGTC_2597 laccaic acid a 100 µM 0.541615588834873 0.277100042536205 no 940 0.294041675279138 1437 5491415 A textile dye.
SGTC_1165 k072-0275 30.3 µM 0.540346427966174 0.277548968983123 no 941 0.294479072791703 1419 6153523 YGL055W OLE1
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.539370934643296 0.277894260999984 no 942 0.294815466106806 1385 6708760
SGTC_588 3970-1144 52.9 µM 0.538209915799054 0.278305495944716 no 943 0.295216067571065 1418 1888707
SGTC_2159 5658611 73.75 µM 0.538057917742232 0.278359355880388 no 944 0.295268531986924 1437 793844
SGTC_3094 9117742 49.47 µM 0.537605424113695 0.2785197253504 no 945 0.295424742367174 1368 17149698
SGTC_23 0213-0011 39.996 µM 0.536347186875153 0.278965896989934 no 946 0.295859312197887 1489 627608
SGTC_1122 capsaicin 818.572 nM 0.535688586389351 0.279199575634262 no 947 0.296086896555895 1528 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1684 st024538 14.6195 µM 0.531957237482086 0.280525292533812 no 948 0.297377806569988 1433 6732859
SGTC_324 1315-0088 19.6 µM 0.531951411616844 0.280527364794528 no 949 0.29737982411472 1432 6787421
SGTC_3261 9137475 49.47 µM 0.531656794119227 0.280632169920593 no 950 0.297481860713352 1401 17027690
SGTC_3023 9089636 49.47 µM 0.531230644309438 0.280783798921749 no 951 0.297629479944888 1507 17249241
SGTC_2385 9074692 200 µM 0.529857117304594 0.281272785064921 no 952 0.298105500088696 1412 17046906
SGTC_700 3453-2283 142 µM 0.528806933544969 0.281646935665723 no 953 0.29846969371775 1509 565664
SGTC_1579 chlormadinone acetate 49.4 µM 0.528580135341516 0.281727768913442 no 954 0.298548371726824 1525 45114258 A steroidal progestin.
SGTC_592 k241-0073 46.5 µM 0.528444621355332 0.281776072849974 no 955 0.298595387053746 1519 4230158
SGTC_193 1273-0060 1.558 µM 0.528336333002486 0.281814675083504 no 956 0.298632959118711 1367 2847393 YHR072W ERG7
SGTC_506 n9-isopropylolomoucine 153 µM 0.5282023140829 0.281862453183433 no 957 0.298679461717924 1546 6610355
SGTC_2124 5246320 200 µM 0.52807017453715 0.281909565102666 no 958 0.298725315425057 1467 579342
SGTC_1558 st069300 45.6 µM 0.527861479030124 0.28198397936521 no 959 0.298797741312282 1479 24208000
SGTC_916 4466-0038 42 nM 0.526185970453966 0.282581755739699 no 960 0.299379500389188 1474 5722064 YGL116W CDC20
SGTC_505 gw-5074 63.9 µM 0.524625517524461 0.283139030639288 no 961 0.29992177210308 1500 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1882 5615643 20 µM 0.524412602113598 0.28321510866748 no 962 0.299995796616302 1385 2253075
SGTC_1172 0370-0043 85 µM 0.524078023262345 0.283334678766481 no 963 0.300112136678136 1488 376585
SGTC_2810 7959871 45.46 µM 0.524033534157636 0.28335057988108 no 964 0.300127608006969 1523 2974535
SGTC_329 k048-0121 21.3 µM 0.523086289464226 0.283689241724773 no 965 0.300457103078631 1445 6832902
SGTC_359 0081-0058 15.9 µM 0.520021490952 0.284786304299675 no 966 0.301524298152951 1609 3494159
SGTC_3082 9117008 49.47 µM 0.519996006369239 0.284795435136178 no 967 0.30153317929883 1452 41448529
SGTC_1784 st039334 36.3 µM 0.519687135329014 0.28490611122656 no 968 0.30164082741012 1528 3496984
SGTC_759 3486-0358 89.3 µM 0.519496232479564 0.284974526670183 no 969 0.301707369745257 1574 875103
SGTC_724 3910-0327 137 µM 0.518363715730951 0.285380557153079 no 970 0.302102262774051 1422 2885483
SGTC_585 0kpi-0023 191 µM 0.517819330757492 0.285575828331968 no 971 0.30229216488102 1507 64601
SGTC_309 k408-0051 1.48 µM 0.516765484769001 0.285954024052529 no 972 0.3026599384006 1435 3640463
SGTC_3247 9135149 49.47 µM 0.516712968494346 0.285972876894107 no 973 0.302678270890087 1443 8934436 YOR116C RPO31
SGTC_1568 digitonin 820 nM 0.516332358307858 0.286109529973465 no 974 0.302811149944643 1594 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1672 st016598 6.51 µM 0.516282563876197 0.286127410303548 no 975 0.302828536164553 1415 4665860 YNL267W PIK1
SGTC_1216 1165-0504 9.65 µM 0.515751919707742 0.286317988526064 no 976 0.303013843596843 1496 6304004
SGTC_2646 retinol 96.75 µM 0.515751226242101 0.286318237620235 no 977 0.303014085796719 1470 445354 A vitamin A analog and teratogen.
SGTC_1900 st060200 72.8 µM 0.515665021244618 0.286349203419831 no 978 0.303044194437014 1464 688945
SGTC_1186 1319-0216 26 µM 0.514054647271953 0.286927959804611 no 979 0.303606892269859 1566 4565136
SGTC_578 3460-0051 92 µM 0.513377033267433 0.287171654770692 no 980 0.303843803918572 1490 2876744
SGTC_1813 st051246 8.6015 µM 0.511818864610929 0.287732401023083 no 981 0.304388893164954 1487 5291959
SGTC_766 1391-0721 126 µM 0.510927676683079 0.288053349844315 no 982 0.304700850195128 1568 1020919 YIL115C NUP159
SGTC_1395 3486-0190 4.35 µM 0.509628992581784 0.288521354975934 no 983 0.305155704076006 1582 6748079
SGTC_1717 st033143 58.0435 µM 0.506320297556724 0.289715321642568 no 984 0.306315908094587 1581 674616
SGTC_2727 riluzole 51.77 µM 0.505942289288017 0.289851876127263 no 985 0.306448581842251 1471 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_929 2805-0021 398 µM 0.505884291986043 0.289872830169938 no 986 0.306468940043279 1516 3098024
SGTC_2236 dapsone 200 µM 0.50489669126243 0.290229752808172 no 987 0.306815699091144 1468 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1291 0993-0025 5.79 µM 0.504409214285071 0.290406004689584 no 988 0.306986922163222 1564 4353356
SGTC_2918 7977171 22.06 µM 0.503966277198614 0.290566196193823 no 989 0.307142537405052 1442 2236483
SGTC_1178 0988-0033 191 µM 0.503423823218476 0.290762435030799 no 990 0.307333162826536 1499 5392207
SGTC_2967 9089538 49.85 µM 0.502459099391221 0.291111587767928 no 991 0.307672307998664 1620 728216
SGTC_1405 3909-7894 12 µM 0.501647310149655 0.291405542059764 no 992 0.307957816980265 1553 7104060
SGTC_2288 7946289 167.31 µM 0.501274182606109 0.291540700467455 no 993 0.308089086199547 1609 1246052
SGTC_341 1486-1430 230 µM 0.500251458778985 0.291911312660998 no 994 0.308449014374902 1430 2054753 YPL210C SRP72
SGTC_3071 9117417 49.47 µM 0.500197124365207 0.291931008371536 no 995 0.308468141492414 1511 45595590 YGL055W OLE1
SGTC_1496 4469-0713 57.4 µM 0.500184396080328 0.291935622343755 no 996 0.308472622252712 1535 746691
SGTC_1202 1988-0068 29.6 µM 0.496370373548542 0.293319723294357 no 997 0.309816561784515 1428 2850480
SGTC_1029 k015-0030 64.7 µM 0.496061793465732 0.293431839227705 no 998 0.309925407090213 1534 2208316
SGTC_2669 eugenol 100 µM 0.495598051472801 0.293600367227959 no 999 0.31008901391701 1517 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2583 asiatic acid 100 µM 0.495046730620673 0.293800780457429 no 1000 0.310283567238145 1498 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1618 st003135 44.5 µM 0.494169884675005 0.29411965715578 no 1001 0.310593103135366 1475 1270615
SGTC_1382 3002-2117 298 µM 0.492705321611925 0.294652621375506 no 1002 0.311110408471128 1605 1497314
SGTC_1913 st060213 96.1 µM 0.490306635373914 0.295526480149146 no 1003 0.311958466180647 1570 688959
SGTC_2064 5220758 200 µM 0.4896694677993 0.295758805080279 no 1004 0.312183905267591 1532 788518
SGTC_877 0771-0151 33.1 µM 0.489572976463672 0.295793995200775 no 1005 0.312218051430302 1536 6166523
SGTC_1334 1486-0610 236 µM 0.489362579757275 0.295870732960621 no 1006 0.312292511792981 1518 3742339
SGTC_1454 4239-0054 42.6 µM 0.488327085536434 0.296248540796471 no 1007 0.312659089637071 1588 1340767
SGTC_2046 4110841 106 µM 0.48748571811116 0.296555682852351 no 1008 0.312957080722487 1508 44119630 YMR134W ERG29
SGTC_216 k038-0035 28.382 µM 0.486815440019411 0.296800472925979 no 1009 0.313194563783233 1464 4444231 YPR107C YTH1
SGTC_342 k048-0088 23.3 µM 0.483830393377613 0.297891753498348 no 1010 0.314253121554309 1460 6820570
SGTC_2018 5133068 143 µM 0.482862120430931 0.29824612962252 no 1011 0.314596819653039 1482 785362
SGTC_2362 9071156 126 µM 0.482467985277029 0.298390433249787 no 1012 0.314736767882673 1565 653133
SGTC_2913 7966556 36.57 µM 0.481456373652917 0.298760957219331 no 1013 0.315096089432075 1582 2976516
SGTC_308 4092-1169 104 µM 0.481019565277173 0.298921012064073 no 1014 0.315251296642958 1526 2268590 YDL196W YDL196W
SGTC_38 0929-0051 58.268 µM 0.480939769803471 0.298950254840913 no 1015 0.315279653178342 1612 1379719
SGTC_198 3454-2873 16.191 µM 0.480879421689165 0.29897237157528 no 1016 0.315301099521488 1499 710957
SGTC_2301 7769476 200 µM 0.478945228695231 0.299681619299451 no 1017 0.315988796902476 1575 977820
SGTC_1365 1672-3266 55.4 µM 0.477960922410233 0.300042846191329 no 1018 0.316339009319711 1569 6415873
SGTC_2595 hexamethylquercetagetin 100 µM 0.477544460919777 0.30019574111977 no 1019 0.316487234357045 1523 386331
SGTC_331 k048-0133 24.5 µM 0.477066701191129 0.300371183758409 no 1020 0.316657312687273 1492 6813582
SGTC_978 1416-0512 87.4 µM 0.476579946103151 0.300549977298868 no 1021 0.316830633158439 1546 6814003
SGTC_2380 9035439 200 µM 0.476045391714936 0.300746383695258 no 1022 0.317021020009212 1584 6462575
SGTC_2735 sertaconazole 140 nM 0.475407179603402 0.300980951913652 no 1023 0.317248389042676 1567 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_656 4090-1979 187 µM 0.474437790942734 0.301337398322114 no 1024 0.317593874786199 1612 22330961
SGTC_1241 0364-0022 50.8 µM 0.473252933705006 0.301773330950216 no 1025 0.318016368378089 1587 4563895
SGTC_137 0438-0332 85.389 µM 0.472140953711731 0.302182708262669 no 1026 0.318413091142165 1478 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2156 5649887 115 µM 0.471956289129829 0.302250716968257 no 1027 0.318478994383363 1616 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2435 5706476 10.6 µM 0.471689516344613 0.302348976801625 no 1028 0.318574210606951 1590 5725375
SGTC_2315 7733312 200 µM 0.470328934017186 0.302850339835822 no 1029 0.319060014305905 1490 726316
SGTC_95 0471-0001 561.058 µM 0.46996444637502 0.302984713626238 no 1030 0.319190209543915 1433 4015405
SGTC_2648 atorvastatin 78.68 µM 0.469755966579099 0.303061584796802 no 1031 0.319264688699323 1598 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2850 9015429 58.44 µM 0.465488847974257 0.304636879784351 no 1032 0.320790710647816 1482 6457570
SGTC_1170 0310-0127 64.8 µM 0.464822771223647 0.30488310402641 no 1033 0.321029189680637 1571 774975
SGTC_2175 5807670 165.306 µM 0.462575030813127 0.305714663432284 no 1034 0.321834504833256 1519 241186
SGTC_2602 kawain 100 µM 0.461694465486923 0.306040705294494 no 1035 0.322150220271506 1508 5369129
SGTC_829 1635-0120 117 µM 0.461674421566857 0.306048128631923 no 1036 0.322157408257879 1648 285054
SGTC_14 0354-0009 295 µM 0.461339736299641 0.306172092284009 no 1037 0.322277440172253 1577 1713507
SGTC_814 3342-0569 96 µM 0.459874813363239 0.306714944286491 no 1038 0.322803039812372 1558 4346283
SGTC_1483 3453-0561 55.9 µM 0.457332915735626 0.307657893770586 no 1039 0.323715887171417 1580 4546991
SGTC_542 3381-0244 89.3 µM 0.457098636277877 0.307744866854254 no 1040 0.323800075222391 1649 1112843
SGTC_2683 piperine 63.03 µM 0.45679936635741 0.307855982485047 no 1041 0.323907630634812 1537 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3041 9091929 49.47 µM 0.456746631813702 0.307875564067731 no 1042 0.323926584566737 1578 25236887
SGTC_1752 st044819 83.042 µM 0.456561750639276 0.307944219139527 no 1043 0.323993038452424 1474 441209 YML126C ERG13
SGTC_2960 9079389 5.97 µM 0.456538084786697 0.307953007868594 no 1044 0.324001545336635 1660 16457355
SGTC_2014 4013930 200 µM 0.456212330269469 0.3080739937088 no 1045 0.324118649799487 1526 64556
SGTC_3177 9107506 49.47 µM 0.455347652385736 0.308395237845718 no 1046 0.324429574508821 1598 8897194
SGTC_1180 1193-0155 285 µM 0.45431382576351 0.308779516563684 no 1047 0.32480148317203 1513 2921347
SGTC_3251 9135047 49.47 µM 0.453543418163298 0.309066017296548 no 1048 0.325078743139271 1640 17682963
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.453389626712306 0.309123223487591 no 1049 0.325134102346605 1501 88881 An O-methylated flavonoid and antioxidant.
SGTC_217 ketoconazole 989 nM 0.45245686710251 0.309470283545131 no 1050 0.325469943811815 1497 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1788 fluconazole 20 µM 0.451937648288395 0.309663547524033 no 1051 0.325656950742639 1519 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1855 st056195 39.6 µM 0.451655245824946 0.309768685663432 no 1052 0.325758682007497 1635 4028379
SGTC_2897 9048598 12.99 µM 0.450702411383487 0.310123539730232 no 1053 0.326102022084456 1530 6467404
SGTC_628 1636-0253 16 µM 0.450520134292485 0.310191443429304 no 1054 0.326167719803911 1625 4456143
SGTC_1683 st010134 710 nM 0.450135890882885 0.310334606857492 no 1055 0.32630622945877 1512 3818134
SGTC_935 2996-0153 430 µM 0.450110372736902 0.310344115560429 no 1056 0.326315428928608 1662 23738523
SGTC_3297 9117502 71.43 µM 0.450058763251557 0.310363346940023 no 1057 0.326334034831454 1555 7453720
SGTC_2639 lactacystin 53 µM 0.449291409777591 0.310649349045373 no 1058 0.326610726881022 1635 3870 A proteasome inhibitor.
SGTC_3016 9080866 49.47 µM 0.449184200594084 0.310689316348308 no 1059 0.326649391930419 1509 17066299
SGTC_1058 3448-5425 97.3 µM 0.448794636519319 0.310834563621968 no 1060 0.326789904095567 1500 7279705
SGTC_1450 4112-4260 37.6 µM 0.448519572730734 0.310937137719432 no 1061 0.326889131863597 1642 1633175
SGTC_1424 4048-1941 275 µM 0.446310015622725 0.311761636594967 no 1062 0.327686661245014 1668 X1424
SGTC_1467 k284-1082 293 µM 0.444701077331691 0.312362608382464 no 1063 0.328267895331393 1663 3334705
SGTC_358 0075-0058 9.45 µM 0.444316480833721 0.312506337169039 no 1064 0.328406893695213 1793 1069125
SGTC_369 0957-0393 4.5 µM 0.444186230377523 0.312555019950438 no 1065 0.328453973353106 1508 6997992
SGTC_2723 salbutamol 83.58 µM 0.442096828327802 0.31333640742931 no 1066 0.329209569711789 1590 9884233 β2-adrenoceptor agonist
SGTC_699 0375-0592 111 µM 0.441956799004595 0.313388805144549 no 1067 0.329260233907712 1616 762578
SGTC_781 4335-2806 94.4 µM 0.439821126158728 0.314188421048626 no 1068 0.33003333266689 1692 845254
SGTC_2054 5233173 129 µM 0.439405271203638 0.314344222687624 no 1069 0.330183953872441 1598 6889
SGTC_3315 9136395 68.55 µM 0.438928266005381 0.314522975230469 no 1070 0.330356757374458 1646 16876844
SGTC_2752 diclazuril 33.15 µM 0.436693094607688 0.315361160328591 no 1071 0.331166968931216 1619 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1005 4092-0690 4.4 µM 0.435011897145192 0.315992233299152 no 1072 0.331776895924039 1541 1529343
SGTC_836 0330-0104 1.35 µM 0.434996123755011 0.315998156717837 no 1073 0.331782620517735 1597 46494820
SGTC_2774 tamoxifen 10.92 µM 0.434524347019122 0.316175345986973 no 1074 0.331953859319633 1581 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2423 st077119 87.2 µM 0.434110673750586 0.316330747581005 no 1075 0.332104037441228 1533 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3187 9109394 49.47 µM 0.433872496689635 0.316420236524058 no 1076 0.332190516428914 1518 17098090
SGTC_568 1193-0097 7.48 µM 0.432578452592209 0.316906628279751 no 1077 0.332660523061759 1540 3646150
SGTC_2057 5236571 38.335 µM 0.432236545732359 0.317035193564155 no 1078 0.332784750206278 1681 54684039 YBR257W POP4
SGTC_39 0986-0283 58.349 µM 0.431672839046769 0.317247209201082 no 1079 0.332989605343796 1723 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1516 st013856 110 µM 0.43047656632506 0.317697337828387 no 1080 0.333424504706972 1561 5281404 A mutagen and neurotoxin.
SGTC_3014 9081533 49.47 µM 0.430452596347285 0.317706359911213 no 1081 0.333433221171486 1684 21367265
SGTC_1369 1866-0067 208 µM 0.43032918912153 0.317752810987911 no 1082 0.333478098510634 1687 3531355
SGTC_257 daunorubicin 18.5 µM 0.429307607101403 0.318137449505993 no 1083 0.333849690782019 1715 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3276 9139060 49.47 µM 0.429252215733072 0.318158310666407 no 1084 0.333869843609915 1614 4870619
SGTC_1420 4'-methoxyflavone 42 µM 0.428748473279477 0.318348053557182 no 1085 0.334053140271727 1669 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2177 5811945 192 µM 0.428258980447299 0.31853247475671 no 1086 0.334231289855451 1669 5343475
SGTC_865 0488-0499 301 µM 0.427882885187188 0.318674202866347 no 1087 0.334368194076223 1599 9634651
SGTC_3145 9085516 49.47 µM 0.426754804514785 0.319099468962091 no 1088 0.334778964169185 1550 25236195
SGTC_74 000s-0487 160.283 µM 0.42589151710461 0.319425073694733 no 1089 0.33509344823019 1484 677548
SGTC_3356 9151811 4.48 µM 0.424281783695606 0.320032586142347 no 1090 0.33568016130907 1562 1859254 YPR165W RHO1
SGTC_484 loperamide 105 µM 0.423177871687439 0.320449481134827 no 1091 0.336082745185023 1593 3955 An opioid-receptor agonist.
SGTC_15 0266-0086 27.098 µM 0.421859926541386 0.320947503084379 no 1092 0.336563630779456 1650 1712902 YIL048W NEO1
SGTC_2767 sibutramine 71.45 µM 0.42143058962325 0.321109809534974 no 1093 0.336720342989517 1710 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.421247898232475 0.321178884523971 no 1094 0.336787035751197 1699 23847180
SGTC_997 3996-0078 137 µM 0.420971702035045 0.321283325107213 no 1095 0.336887872837307 1598 735687
SGTC_234 nsc-17383 10.7 µM 0.420776779380861 0.321357041493567 no 1096 0.336959044641888 1672 408974
SGTC_2536 dehydroabietamide 32.04 µM 0.419673441297571 0.321774437517414 no 1097 0.337362014730804 1718 3983547
SGTC_2077 5212015 200 µM 0.419567278925018 0.32181461092879 no 1098 0.337400798063386 1508 780900
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.417415710702505 0.322629244511634 no 1099 0.338187182677068 1579 15053
SGTC_2674 ligustilide 100 µM 0.417410976268901 0.322631038018887 no 1100 0.338188913862886 1606 5319022 A signalling regulator.
SGTC_1971 st069429 63.5 µM 0.415923633312591 0.323194680247345 no 1101 0.338732942629596 1682 1246522 YGL099W LSG1
SGTC_84 0443-0269 128.823 µM 0.415454308912495 0.323372619383578 no 1102 0.338904678388973 1588 6150058
SGTC_3195 9113082 49.47 µM 0.414842795993185 0.323604528340331 no 1103 0.339128494185305 1704 17018038
SGTC_726 3448-4391 34.2 µM 0.414464211402194 0.323748136365441 no 1104 0.339267085890206 1720 1356692
SGTC_638 3970-0837 4.09 µM 0.413909205102147 0.323958713657329 no 1105 0.339470301108612 1580 4118451 YLR208W SEC13
SGTC_458 nppb 133 µM 0.413882669629029 0.323968783005583 no 1106 0.339480018225805 1738 4549 A chloride channel blocker.
SGTC_1951 sophoraflavanone G 9.2 µM 0.413773481725732 0.32401021761594 no 1107 0.339520003246837 1568 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1973 st070275 50.2 µM 0.412838511126823 0.324365109359469 no 1108 0.339862466922983 1612 17118334
SGTC_475 α-linolenic acid 10 µM 0.412139914015454 0.324630383762067 no 1109 0.340118437363775 1684 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1343 1487-0095 224 µM 0.411976036382787 0.32469262499635 no 1110 0.340178493851742 1700 4560101 YGL055W OLE1
SGTC_503 tyrphostin 8 294 µM 0.411034437225746 0.32505034211256 no 1111 0.340523641681344 1689 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1507 4075-3230 155 µM 0.410450723547574 0.325272178196416 no 1112 0.340737671919926 1616 659771
SGTC_1811 st050069 61.5 µM 0.41012986030608 0.325394146292344 no 1113 0.340855344661471 1651 3877702
SGTC_2182 6325192 200 µM 0.408421061765677 0.326044017875718 no 1114 0.341482286615227 1612 736248
SGTC_483 fpl-64176 144 µM 0.408069139353182 0.326177922882221 no 1115 0.34161145800994 1632 3423
SGTC_1975 st070967 30.8 µM 0.408030209342942 0.326192736965458 no 1116 0.34162574821902 1729 261391
SGTC_1617 st002906 78 µM 0.407745780677395 0.326300979265323 no 1117 0.341730161579547 1601 5150859
SGTC_2186 6124449 200 µM 0.407426796306332 0.326422389505942 no 1118 0.341847274696586 1658 3834182 YLR033W RSC58
SGTC_2976 9009005 19.48 µM 0.407335517325676 0.326457135041395 no 1119 0.341880790004975 1761 2993148
SGTC_1280 0880-0253 10.1 µM 0.40720697820601 0.326506066280094 no 1120 0.341927988396909 1594 6836607
SGTC_989 1501-0895 10.3 µM 0.40647717303965 0.326783939214482 no 1121 0.342196013009454 1729 2830112
SGTC_1333 1482-0047 286 µM 0.406457933604056 0.326791265920222 no 1122 0.342203079865139 1710 3811116
SGTC_2324 6149169 200 µM 0.406352286028893 0.32683149951184 no 1123 0.34224188636295 1667 2888231
SGTC_3080 9117754 49.47 µM 0.405892765079313 0.327006521535882 no 1124 0.342410697108642 1735 9550191
SGTC_1445 4239-0156 97.7 µM 0.405042089406731 0.327330626719973 no 1125 0.342723286495729 1753 4008346
SGTC_3035 9091303 49.47 µM 0.401048903744831 0.328853756785536 no 1126 0.344192059553972 1630 25237002
SGTC_1702 st027038 51 µM 0.400355845424905 0.329118402249504 no 1127 0.344447220473955 1640 5521182
SGTC_2635 hydroquinidine 100 µM 0.398850228707522 0.329693619528256 no 1128 0.345001782115189 1626 442912 An experimental heart treatment.
SGTC_1714 st033236 13.627 µM 0.397971990404499 0.330029334610488 no 1129 0.345325416263592 1731 2916566
SGTC_1359 1582-0056 520 nM 0.397528322057191 0.330198983200728 no 1130 0.345488952759876 1668 3661189
SGTC_2690 usnic acid 100 µM 0.397397086537574 0.330249171343345 no 1131 0.345537331803365 1768 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2242 6630449 61.2675 µM 0.397288611007891 0.330290657733245 no 1132 0.345577322442749 1654 691249 YDR170C SEC7
SGTC_2722 naftopidil 47.16 µM 0.395263657313957 0.331065482343467 no 1133 0.346324158764952 1680 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3328 9140624 29.0385 µM 0.393977125391328 0.331558134953855 no 1134 0.346798963780841 1754 4904392
SGTC_1958 st076513 41.9 µM 0.393111416872684 0.331889805502962 no 1135 0.347118596045513 1593 732122 YGL099W LSG1
SGTC_1673 st016611 27.3 µM 0.392618011364018 0.332078898171601 no 1136 0.34730081727311 1725 5226799
SGTC_1364 1653-0028 37.6 µM 0.389402511120835 0.333312251832921 no 1137 0.348489207370532 1654 5718652
SGTC_2464 5717415 7.67 µM 0.388013658812415 0.333845525938448 no 1138 0.349002962843421 1556 5285744
SGTC_389 tpck 16.7 µM 0.387802536148234 0.333926619598393 no 1139 0.349081084274948 1643 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3223 9129970 49.47 µM 0.387320466521297 0.334111814909505 no 1140 0.349259487814012 1660 17248386
SGTC_1341 1486-1360 280 µM 0.386348616068492 0.334485290698496 no 1141 0.349619249881624 1615 3976547
SGTC_1262 0737-0114 49.6 µM 0.385283876809559 0.334894651150624 no 1142 0.350013552846209 1754 765919
SGTC_3110 9122132 49.47 µM 0.381320777560205 0.336420065949439 no 1143 0.35148261900001 1750 918317
SGTC_1992 st073643 23.3 µM 0.380315376321619 0.336807479227863 no 1144 0.35185566144627 1659 3161292
SGTC_48 0382-0018 55 µM 0.379008817228562 0.337311197056457 no 1145 0.352340658136207 1777 762596
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.377414894114613 0.337926097365867 no 1146 0.352932650002677 1595 6708514
SGTC_1091 telmisartan 47.6 µM 0.375042013795754 0.338842303452597 no 1147 0.353814610406388 1736 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_114 0364-0001 490.298 µM 0.374300044322878 0.3391289855345 no 1148 0.354090549552889 1607 4003655
SGTC_2092 5303694 80.6725 µM 0.37429655178891 0.339130335199815 no 1149 0.354091848610902 1644 1963699
SGTC_2733 amorolfine 100 µM 0.373847361262391 0.339303938937396 no 1150 0.35425894046374 1758 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2402 5553605 200 µM 0.373610885507077 0.339395346103992 no 1151 0.354346917024509 1732 6758546
SGTC_2994 9053520 71.4286 µM 0.372751355306814 0.339727667850109 no 1152 0.354666755251466 1773 4647384
SGTC_3345 9148410 3.559 µM 0.372142024603358 0.339963330007694 no 1153 0.354893554289957 1760 4903596
SGTC_500 h-89 112 µM 0.37212060769369 0.339971614259203 no 1154 0.354901526816028 1807 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2898 9056270 58.44 µM 0.37172710298818 0.340123839135206 no 1155 0.355048021744516 1684 19154699
SGTC_1030 k029-0042 36.7 µM 0.370569211634265 0.340571913389102 no 1156 0.355479208702312 1679 6080581
SGTC_2528 xanthyletin 44.79 µM 0.36934062771096 0.341047589995581 no 1157 0.355936923187293 1660 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1223 0764-0573 147 µM 0.366738326012892 0.342055969299131 no 1158 0.356907107722091 1659 1609797
SGTC_661 1304-0007 33.6 µM 0.366627693802853 0.342098863780838 no 1159 0.356948373953669 1649 3117130
SGTC_1734 st037168 69.4 µM 0.366358079710749 0.342203407482934 no 1160 0.357048948036067 1655 708907
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.365575256172527 0.342507018261322 no 1161 0.357341020795683 1839 551469
SGTC_2277 7947813 106.88 µM 0.365255748084726 0.342630965743576 no 1162 0.357460253824774 1785 1246798
SGTC_1328 1441-0025 69.2 µM 0.363864755227318 0.343170774016678 no 1163 0.357979502216472 1582 4562601
SGTC_1482 3346-2049 8.48 µM 0.362913563970776 0.343540091096012 no 1164 0.358334726987423 1747 3826804
SGTC_828 2074-0507 139 µM 0.362336034215572 0.34376440031362 no 1165 0.358550466786472 1772 X828
SGTC_2365 9042475 200 µM 0.361810392618526 0.343968604294384 no 1166 0.358746862693734 1655 6464479
SGTC_1644 st010134 20.9 µM 0.361644613478623 0.344033016481143 no 1167 0.35880881064226 1776 3818134
SGTC_2514 salinomycin 42.74 µM 0.361482671180955 0.344095942263076 no 1168 0.358869328435 1839 23682228 A polyether potassium ionophore.
SGTC_2961 9083290 32.55 µM 0.36040925044457 0.34451314953418 no 1169 0.359270554976705 1693 17741490
SGTC_988 1497-1057 103 µM 0.360182149875858 0.344601441157678 no 1170 0.359355461245034 1816 3533044
SGTC_1659 st012954 42.1 µM 0.360005456410918 0.344670141482577 no 1171 0.359421526574103 1724 24207262
SGTC_2270 7924575 90.91 µM 0.359630547181632 0.344815927199246 no 1172 0.359561718292919 1844 1262135
SGTC_1315 1237-0019 3.69 µM 0.358863682157145 0.345114199050525 no 1173 0.359848534898949 1764 825140
SGTC_2249 haloperidol 116.36 µM 0.358801073719357 0.345138554830153 no 1174 0.359871954684159 1742 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.357395930264347 0.345685348853033 no 1175 0.360397711514587 1795 688798
SGTC_1375 2910-0797 186 µM 0.356936211642974 0.345864312592303 no 1176 0.360569779948221 1711 742508
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.356531404306279 0.346021928450828 no 1177 0.360721318975567 1729 616764
SGTC_1103 duloxetine 36.1 µM 0.356282512171133 0.346118850385364 no 1178 0.360814502237729 1793 60835 A selective serotonin reuptake inhibitor.
SGTC_349 k015-0014 24 µM 0.355386342935118 0.346467914156887 no 1179 0.361150089373649 1650 2196908
SGTC_2052 5265182 7.135 µM 0.355065816893638 0.346592792825083 no 1180 0.36127014224074 1785 1239884
SGTC_2625 euphol 100 µM 0.353972539271681 0.347018865010816 no 1181 0.361679731542782 1821 6708538 A triterpene alcohol.
SGTC_1743 st037606 46.3785 µM 0.353647265420871 0.347145668115423 no 1182 0.361801623881407 1685 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1721 st082152 9.2685 µM 0.352781351039075 0.347483315170906 no 1183 0.362126182870136 1647 5296051
SGTC_499 genistein 192 µM 0.351895012454972 0.3478290516306 no 1184 0.362458499881776 1758 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2204 7233102 200 µM 0.350756776972108 0.348273231799394 no 1185 0.362885413202882 1750 2172480
SGTC_3316 9136639 10.545 µM 0.34954121409407 0.348747817768481 no 1186 0.363341517623482 1762 4903665
SGTC_1407 3909-7909 12.3 µM 0.347890756576906 0.349392576310458 no 1187 0.363961113689609 1683 4411780
SGTC_607 4491-0986 66.8 µM 0.347464138184479 0.34955930747416 no 1188 0.364121327874486 1812 698981 YDR232W HEM1
SGTC_1065 prochlorperazine maleate 2.48 µM 0.347040494284295 0.349724904869725 no 1189 0.364280448508486 1710 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2472 5377652 49.4 µM 0.3450984519168 0.350484391854418 no 1190 0.365010178618447 1684 1610903
SGTC_473 2-arachidonoylglycerol 10 µM 0.343882646058459 0.350960169507676 no 1191 0.365467271648555 1673 5282280 An endocannabinoid.
SGTC_1024 4507-0395 26 µM 0.342205838347522 0.351616733046013 no 1192 0.366097995909795 1731 4201836
SGTC_2935 9038016 29.96 µM 0.341638560265369 0.351838954343238 no 1193 0.366311457238906 1824 6463195
SGTC_2689 tacrolimus 100 µM 0.341300072184719 0.351971575267266 no 1194 0.366438846786414 1697 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_357 1325-0123 420 µM 0.341196990966906 0.352011966460638 no 1195 0.366477644192316 1829 1098503
SGTC_2962 9082311 13.18 µM 0.340661447872075 0.352221839747186 no 1196 0.366679232281381 1649 16459453
SGTC_1113 artemisinin 1.17947 µM 0.339763100633938 0.352573992936307 no 1197 0.36701746897057 1866 2240 An anti-malaria and mitochondrial poison.
SGTC_696 1560-0013 611 µM 0.338954709773223 0.352890991168975 no 1198 0.367321924456639 1784 1650269
SGTC_1057 3448-5381 134 µM 0.338640536542774 0.353014217018315 no 1199 0.367440270638206 1821 5497911
SGTC_1833 st055984 71 µM 0.337684384291196 0.3533893363761 no 1200 0.36780052187484 1731 676288
SGTC_2116 5511452 16.8835 µM 0.337317727170752 0.353533221761822 no 1201 0.36793869882553 1747 870744
SGTC_1142 3253-1408 9.78 µM 0.336682917537341 0.353782386353719 no 1202 0.368177971071308 1833 256655
SGTC_1649 st011737 51.3 µM 0.336355420786969 0.353910954265476 no 1203 0.368301431046957 1706 1761035
SGTC_589 1227-0070 34.1 µM 0.335877974857011 0.354098418722937 no 1204 0.368481443342821 1756 2841384
SGTC_2174 5790901 200 µM 0.334483533372931 0.354646134832989 no 1205 0.36900735727387 1718 786020
SGTC_2141 5621638 7.665 µM 0.334478415690095 0.354648145537959 no 1206 0.369009287861583 1848 2856238
SGTC_875 0709-0210 25.7 µM 0.334459469973023 0.354655589224695 no 1207 0.369016434946887 1840 6251364
SGTC_2071 5230951 39.92 µM 0.334127413290272 0.35478606180544 no 1208 0.369141707413205 1788 1799272
SGTC_2271 7849410 118.62 µM 0.332949409114423 0.355249063610166 no 1209 0.369586236010431 1884 972430
SGTC_100 0086-0128 49.5915 µM 0.332735332121863 0.355333227230627 no 1210 0.369667038289538 1635 93297
SGTC_1660 st012960 28.1 µM 0.328852812279461 0.356860847123024 no 1211 0.371133471309648 1736 24207266
SGTC_1801 st050089 28.441 µM 0.328659559404485 0.356936944823547 no 1212 0.371206512294131 1721 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2075 5212009 200 µM 0.327027308023301 0.357579907631249 no 1213 0.371823615490795 1824 780898
SGTC_2255 7941087 197.44 µM 0.32293826694519 0.359192400577728 no 1214 0.373370997420084 1860 935561
SGTC_1587 estradiol valerate 56.1 µM 0.322907711586553 0.359204459419763 no 1215 0.373382567956629 1874 13791 A steroid.
SGTC_3267 9137951 49.47 µM 0.32283073246014 0.359234840281453 no 1216 0.373411718498418 1772 16643986
SGTC_1518 st038567 90.8 µM 0.322671760736276 0.359297583456418 no 1217 0.373471920381444 1739 77966
SGTC_2705 st078069 42.8 µM 0.321937046235382 0.35958761083831 no 1218 0.373750193583405 1729 1530061
SGTC_1040 k898-0338 155 µM 0.321833956713098 0.35962831173873 no 1219 0.373789244021205 1916 20969351
SGTC_563 tetrahydrosecaminediol 614 µM 0.321533789080125 0.359746830355388 no 1220 0.373902955266783 1856 334274 A psychoactive constituent of the cannabis plant.
SGTC_1880 MG-132 525 µM 0.321284138977894 0.359845412833287 no 1221 0.373997537528465 1835 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2997 9067075 71.4286 µM 0.320820635730712 0.360028466916917 no 1222 0.374173160156092 1797 27209819
SGTC_561 1550-0330 72.9 µM 0.320652230895494 0.360094983989524 no 1223 0.374236975671564 1715 6812934
SGTC_304 1310-0298 97 µM 0.320293285559976 0.360236775484479 no 1224 0.374373006314455 1752 1550234
SGTC_2197 6588183 93.1375 µM 0.318761089886476 0.360842243290004 no 1225 0.374953843004732 1778 884136
SGTC_1916 st067606 49.2 µM 0.318672476830171 0.360877270623365 no 1226 0.374987443825074 1845 19590279
SGTC_351 caspofungin 25 nM 0.31866775909698 0.360879135501065 no 1227 0.374989232749523 1805 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.315151255653199 0.362270095112396 no 1228 0.376323406706408 1650 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1854 st056233 32.9 µM 0.313980799462303 0.362733476015794 no 1229 0.3767678108497 1886 5393174
SGTC_2568 diosmetin 100 µM 0.313673411331277 0.362855203636178 no 1230 0.37688454848188 1889 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3052 9092717 49.47 µM 0.312611053622543 0.363276010578319 no 1231 0.377288089591921 1740 25237534
SGTC_3051 9093778 49.47 µM 0.309271451057683 0.364599922311041 no 1232 0.378557522946196 1793 17217378
SGTC_1718 roemerine 11.9335 µM 0.308173932238751 0.365035363130566 no 1233 0.378974993437846 1775 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1265 0819-1001 68.8 µM 0.308149877985924 0.365044908612085 no 1234 0.378984144696253 1756 3106768
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.307650480612229 0.365243104027602 no 1235 0.379174151962739 1795 688801
SGTC_565 1418-0001 44.5 µM 0.307200463720792 0.365421732689372 no 1236 0.379345396292768 1848 2862145
SGTC_1293 1000-1278 195 µM 0.303475135327255 0.366901573815582 no 1237 0.380763896843943 1843 678847
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.302980996327684 0.367098013702986 no 1238 0.380952172036149 1864 6710655
SGTC_541 4513-1321 94 µM 0.30266786521741 0.367222513777678 no 1239 0.381071494800944 1730 747515
SGTC_1210 3013-0140 750 nM 0.301342410705603 0.367749665360554 no 1240 0.381576701957403 1914 905973
SGTC_3091 9116372 49.47 µM 0.300905019975289 0.367923676441549 no 1241 0.381743461119584 1815 17169793
SGTC_1300 1094-0077 113 µM 0.300777281047256 0.367974501082222 no 1242 0.381792166880817 1746 5532636
SGTC_1017 4239-0030 168 µM 0.299365809096684 0.368536249861991 no 1243 0.38233047348851 1699 1149593
SGTC_557 1315-0110 16.2 µM 0.29886598856322 0.368735239846547 no 1244 0.382521149439927 1735 6833801
SGTC_1561 5-methoxyflavone 52.9 µM 0.29737615846636 0.369328583916288 no 1245 0.383089671808334 1895 94525
SGTC_1250 0485-0349 40.2 µM 0.297275449426716 0.369368703843852 no 1246 0.383128111697982 1748 6842794 YDL195W SEC31
SGTC_1928 4'-methoxychalcone 40.3 µM 0.297137294516368 0.369423743571171 no 1247 0.383180846269507 1965 641818
SGTC_2876 9059903 25.97 µM 0.296728040028876 0.369586802739474 no 1248 0.38333707390372 1794 6916095
SGTC_1321 1326-2144 215 µM 0.296546681569851 0.369659068849783 no 1249 0.383406311229911 1899 3513030
SGTC_2149 5554786 194.827 µM 0.294508068738231 0.370471713419796 no 1250 0.384184849356941 1800 745063 YPR165W RHO1
SGTC_3278 9139605 49.47 µM 0.294336730196792 0.370540039855197 no 1251 0.384250304205166 1879 7958859
SGTC_2740 felodipine 17.08 µM 0.293719054766376 0.370786390534126 no 1252 0.384486296316399 1919 3333 L-type calcium channel blocker
SGTC_1387 3342-1166 1.8 µM 0.292802811717653 0.371151918033512 no 1253 0.384836439481451 1814 3418228
SGTC_418 lividomycin a 100 µM 0.292186437634888 0.371397880755883 no 1254 0.385072040307051 1894 72394 An antibiotic.
SGTC_1452 4194-0072 190 µM 0.29178788969937 0.371556948401503 no 1255 0.38522440256933 1932 1343545
SGTC_2368 9071271 200 µM 0.291511282604679 0.371667360162294 no 1256 0.385330158065718 1726 27209959
SGTC_200 k038-0079 37.545 µM 0.29098911762485 0.371875818709058 no 1257 0.385529821218018 1826 3436683
SGTC_51 1013-0126 23.419 µM 0.289226617804078 0.372579720435694 no 1258 0.386203981907235 1958 1627850
SGTC_1807 st050092 58.9 µM 0.288672173607205 0.372801240795906 no 1259 0.386416129397866 1798 5008496
SGTC_391 gliotoxin 8.33 µM 0.28826521230248 0.372963863223972 no 1260 0.386571866987567 1836 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_291 SEC14.278 35.5 µM 0.288075031705705 0.373039867476955 no 1261 0.386644652329354 1885 1068044
SGTC_1829 berberine 14.4 µM 0.286931247578208 0.373497076379132 no 1262 0.387082481951223 1915 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1135 dihydrocapsaicin 536.708 nM 0.285887587119162 0.373914417937009 no 1263 0.387482110597948 1681 107982 A Capsaicinoid.
SGTC_1214 0358-0031 63.7 µM 0.283657389552484 0.374806729926321 no 1264 0.38833647606256 1960 4301366
SGTC_2003 4023581 200 µM 0.283281087516818 0.374957356306038 no 1265 0.388480686869197 1794 16641307
SGTC_2223 6903751 107.57 µM 0.282991239109827 0.375073389986999 no 1266 0.388591776401319 1870 5598863
SGTC_2830 7992007 71.43 µM 0.279820655914331 0.376343391211283 no 1267 0.389807551690966 1741 1952075
SGTC_1872 amphotericin b 148 nM 0.279744831755887 0.376373779614353 no 1268 0.389836640083993 1903 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3003 9075612 71.4286 µM 0.279303540573469 0.376550653150434 no 1269 0.390005944692402 1822 6501993
SGTC_3228 9131799 49.47 µM 0.277537749490877 0.377258657375565 no 1270 0.390683611947681 1838 17015818
SGTC_1008 4106-0037 6 µM 0.277291892649123 0.377357267899978 no 1271 0.39077799215618 1829 2905394
SGTC_376 3970-0862 59.1 µM 0.275165655544921 0.378210411637237 no 1272 0.391594485861983 1927 3135186
SGTC_620 0109-0052 432 µM 0.273541630206242 0.37886244547974 no 1273 0.392218447898578 1927 493037
SGTC_1276 0871-0068 94.2 µM 0.272763398169557 0.379175022089985 no 1274 0.392517548513881 1901 3414906
SGTC_393 acivicin 6.25 µM 0.27205884577398 0.379458073454266 no 1275 0.392788386346799 1839 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.270257480422676 0.380182058926778 no 1276 0.39348108714108 1892 5377381
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.269325803107378 0.38055667365694 no 1277 0.39383948875879 1853 7104
SGTC_2235 salicylic acid 500 µM 0.269262770094719 0.380582022420919 no 1278 0.393863739819569 1888 338 A COX inhibitor and kinase inhibitor.
SGTC_650 1328-0195 38 µM 0.268497976988099 0.380889625249359 no 1279 0.394158015926232 1935 2780821
SGTC_2828 7998861 71.43 µM 0.267259974673801 0.381387714219356 no 1280 0.394634500885367 1968 2988188
SGTC_3256 9138902 49.47 µM 0.266398601757507 0.3817343888076 no 1281 0.394966120984559 1909 17228773
SGTC_1794 st048918 76.9 µM 0.26557867055515 0.382064472601405 no 1282 0.395281857135886 1958 672303
SGTC_2902 5787006 60.46 µM 0.265433724229788 0.382122833291871 no 1283 0.39533767970207 1791 591003
SGTC_2093 5331342 194.4 µM 0.264743934006141 0.382400604738805 no 1284 0.395603365110121 1953 33839
SGTC_3312 9133330 71.43 µM 0.264566448145354 0.382472086269742 no 1285 0.395671734911628 1906 17617324
SGTC_522 1273-0010 11.6 µM 0.264518084154411 0.382491565316407 no 1286 0.395690365890191 1865 5705015
SGTC_34 0469-0683 81.75 µM 0.264303814362429 0.382577868041655 no 1287 0.39577291066088 1895 3690923
SGTC_2675 theaflavin digallate 100 µM 0.263972258348831 0.382711422332017 no 1288 0.39590064770102 1867 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_249 wiskostatin 11.211 µM 0.263167911411972 0.383035479773888 no 1289 0.396210581132264 1936 2775510 A n-wasp and actin depolymerizer.
SGTC_1895 st058434 18.3 µM 0.259757584867603 0.384410348220821 no 1290 0.397525385228805 1977 5393175
SGTC_1230 0170-0365 3.77 µM 0.258337177256477 0.384983413926127 no 1291 0.398073348233532 1957 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_446 go6976 132 µM 0.257855235287907 0.385177911344512 no 1292 0.398259316926387 1982 3501 A protein kinase C inhibitor.
SGTC_2037 5169046 200 µM 0.257154248259176 0.385460860378275 no 1293 0.39852985057497 1890 5718022
SGTC_1805 st050013 60.3 µM 0.256667475181608 0.385657379170178 no 1294 0.398717740806377 1927 4037144
SGTC_3056 9094900 49.47 µM 0.255951534031412 0.385946470440173 no 1295 0.398994130592201 1759 25236784
SGTC_2017 5132927 60.65 µM 0.255166272806345 0.386263625441038 no 1296 0.399297339702184 1806 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3017 9080681 49.47 µM 0.254850823131398 0.386391052153098 no 1297 0.399419159872502 1817 16451914
SGTC_890 0929-0006 47.2 µM 0.254074380821698 0.386704750203905 no 1298 0.399719047605096 1798 1378169
SGTC_886 0866-0150 153 µM 0.253719262930701 0.386848249544326 no 1299 0.399856225623325 1994 271463
SGTC_1844 rapamycin 4 nM 0.253653248768818 0.386874926866619 no 1300 0.3998817275091 1865 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_3288 9119690 36.221 µM 0.253522497277467 0.386927767101455 no 1301 0.3999322392888 1791 17595618 YKL019W RAM2
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.250492709153184 0.388152771950447 no 1302 0.401103171137465 2000 6708630 An antioxidant.
SGTC_1591 genipin 88.4 µM 0.249994067888172 0.388354489786635 no 1303 0.401295968077286 1939 442424 A DNA cross-linking agent.
SGTC_654 1124-0271 80.9 µM 0.248701357496409 0.38887757648869 no 1304 0.401795899349122 1796 5403748
SGTC_580 1123-0028 41 µM 0.24709070817224 0.389529596940004 no 1305 0.402419012314633 1933 1677248 YPR107C YTH1
SGTC_425 3825-7017 13.1 µM 0.246540180919321 0.389752531921329 no 1306 0.402632052110603 1909 3397440
SGTC_2444 5485484 36.41 µM 0.246446244100251 0.389790575085571 no 1307 0.402668406117659 1936 6790631
SGTC_2287 7945887 168.79 µM 0.246174605692054 0.389900590973559 no 1308 0.402773536240858 2001 1245853
SGTC_2711 st079103 59.1 µM 0.242934174824934 0.391213671201592 no 1309 0.404028195382225 1976 54693780
SGTC_680 0417-1641 114 µM 0.242888754110293 0.391232085336229 no 1310 0.404045788833525 1842 2835990
SGTC_407 eburnamonine 100 µM 0.242626936839329 0.391338234135208 no 1311 0.404147206023148 1844 3195
SGTC_2652 actinonin 100 µM 0.242460679897625 0.391405644030433 no 1312 0.404211610435755 1921 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_133 0724-0033 378.92 µM 0.242098172893389 0.391552636021598 no 1313 0.404352046959382 1961 280309
SGTC_400 oxethazaine 37.5 µM 0.240674552125416 0.392130045820138 no 1314 0.404903681874133 1868 4621 A local anesthetic.
SGTC_1318 1280-3875 124 µM 0.239940073651609 0.392428037726113 no 1315 0.405188356917551 1909 373245
SGTC_3074 9116018 49.47 µM 0.238658364778422 0.392948202428695 no 1316 0.405685251982958 1889 17027303
SGTC_951 1171-0579 82.7 µM 0.238288163735031 0.393098479289418 no 1317 0.405828800479214 1867 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1050 3232-1156 69.3 µM 0.23677436372406 0.393713146380842 no 1318 0.406415920438093 1847 700529
SGTC_881 0833-0569 170 µM 0.236579795597992 0.393792168548463 no 1319 0.406491398029495 1802 5418700
SGTC_307 1501-1223 22.3 µM 0.235588176110546 0.394194974140241 no 1320 0.406876124669606 1905 2830329
SGTC_1999 st074831 12.5 µM 0.234660490186553 0.39457191178168 no 1321 0.407236127876132 1871 17112523
SGTC_41 0478-0632 82.643 µM 0.233331592558111 0.395112041827721 no 1322 0.407751964115883 2051 3750424
SGTC_3114 9122766 49.47 µM 0.233229044996522 0.395153730645739 no 1323 0.407791776511811 1844 17176985
SGTC_2717 st081029 62.2815 µM 0.233060363354758 0.395222307663628 no 1324 0.407857266442506 2018 5292846
SGTC_2585 alliin 100 µM 0.232315792533513 0.395525049458111 no 1325 0.40814637364079 1943 87310 A garlic compound which reacts with lipids.
SGTC_982 1491-0518 27.5 µM 0.232025317498318 0.395643173441708 no 1326 0.408259174901487 1891 3091256
SGTC_1883 5-benzylidenerhodanine 20 µM 0.231963378268047 0.395668362762778 no 1327 0.408283228979001 2005 1273210
SGTC_2293 7624732 200 µM 0.231471126583621 0.395868566169414 no 1328 0.40847440702161 1883 894453
SGTC_1905 st060207 84.5 µM 0.229085347545592 0.396839273379115 no 1329 0.409401290814685 1878 1948547
SGTC_2792 7535235 81.82 µM 0.226837483023757 0.39775445235452 no 1330 0.410275058039378 1833 1281891
SGTC_2185 6113692 200 µM 0.225666686885183 0.398231344955046 no 1331 0.410730334876122 1912 874150
SGTC_1340 1486-1359 257 µM 0.225080776917595 0.398470056894802 no 1332 0.410958217555536 1921 4309068
SGTC_1010 4112-3296 15.2 µM 0.22301727470495 0.39931107271224 no 1333 0.41176103089806 2067 704384
SGTC_2773 thioridazine 9.09 µM 0.222771948814824 0.399411090669073 no 1334 0.411856500505571 2030 5452 An antipsychotic.
SGTC_2355 9061122 103.12 µM 0.222093493399824 0.399687727404713 no 1335 0.412120551450262 2001 5302957
SGTC_2822 7994718 71.43 µM 0.221766973323767 0.399820882260579 no 1336 0.412247645375745 1971 1018011
SGTC_2319 6033012 152.6 µM 0.221003179620405 0.400132402734864 no 1337 0.412544978606395 1864 847246
SGTC_1570 verbenone 133 µM 0.220134720415592 0.400486689232552 no 1338 0.41288311749314 2048 29025 A natural terpanoid with antifungal properties.
SGTC_1590 st077108 57.8 µM 0.220040484856571 0.40052513740335 no 1339 0.412919812466671 2023 5489485
SGTC_361 000s-0510 1.45 µM 0.219185085487531 0.400874184955892 no 1340 0.413252936538362 1899 660
SGTC_577 r071-0003 38.6 µM 0.21734178095783 0.401626618047293 no 1341 0.413970999351507 1929 4568517 YMR134W ERG29
SGTC_1949 st076024 69.1 µM 0.21507979361386 0.402550454936101 no 1342 0.414852553804379 1804 2921930
SGTC_671 0560-0003 407 µM 0.214631231720402 0.402733720649392 no 1343 0.415027420979449 1966 3238678
SGTC_1607 st000305 50.6 µM 0.214091554164901 0.402954241159554 no 1344 0.415237830955324 2017 5457690
SGTC_648 0375-0473 33.3 µM 0.213313856671782 0.403272074542117 no 1345 0.41554108310659 1936 1713139
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.213156995488486 0.403336189123197 no 1346 0.415602255012096 2067 688664
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.212178393446341 0.403736236167749 no 1347 0.415983931256005 2003 368090
SGTC_2417 cerulenin 830 nM 0.210787476546332 0.40430500845271 no 1348 0.416526555631566 2053 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1470 k295-0292 231 µM 0.208646449691149 0.405180909944896 no 1349 0.41736212344822 2014 5045612
SGTC_2414 st077232 92.9 µM 0.202055395057113 0.407880297976911 no 1350 0.419936709085501 1802 729801
SGTC_937 3122-0005 46.7 µM 0.202030894304423 0.407890340588204 no 1351 0.41994628599164 2064 759535
SGTC_940 3232-1287 54.8 µM 0.198788913273578 0.409219727249263 no 1352 0.421213934421321 2089 1585493 YIL048W NEO1
SGTC_148 3253-0744 288.01 µM 0.196767716860499 0.410049056236239 no 1353 0.422004657701429 2077 6893655
SGTC_590 k048-0076 22.4 µM 0.19661175475669 0.410113066739202 no 1354 0.422065685598776 2056 6832814
SGTC_822 1487-0950 154 µM 0.194795963230366 0.410858485984546 no 1355 0.422776341315673 2081 1958375
SGTC_1571 st070080 73.4 µM 0.191422633563028 0.412244159173921 no 1356 0.424097244453817 2028 4315245
SGTC_2431 5490079 200 µM 0.1914026369418 0.412252376529404 no 1357 0.42410507713902 1947 5722345
SGTC_3097 9117246 49.47 µM 0.190764386047959 0.412514677753058 no 1358 0.424355096023476 2069 16423892
SGTC_2815 7968870 71.43 µM 0.18962571283851 0.41298273392265 no 1359 0.424801218421115 1954 2977326 YHR190W ERG9
SGTC_2257 7960413 200 µM 0.189351021286099 0.41309566553134 no 1360 0.424908854660008 1999 2974689 YIL048W NEO1
SGTC_2966 9084041 48.03 µM 0.188025411998372 0.413640752969395 no 1361 0.425428365276938 1771 17741380
SGTC_1915 st067105 30.6 µM 0.186523611919594 0.414258490719133 no 1362 0.426017082060301 2021 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3220 9131269 49.47 µM 0.185673250457373 0.414608365394395 no 1363 0.426350503286258 2069 17722206
SGTC_2366 9070441 60.58 µM 0.185474458001694 0.414690166800989 no 1364 0.426428456122615 1968 6837235
SGTC_2883 9059145 45.46 µM 0.184322558448228 0.415164236400375 no 1365 0.426880209013389 1957 16476510
SGTC_227 fluconazole 33.516 µM 0.183121093796691 0.41565883637329 no 1366 0.427351502582318 1947 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.183051886049543 0.41568733080282 no 1367 0.427378653584122 2044 2333 A French combination drug.
SGTC_2626 ethyl orsellinate 100 µM 0.182729153488951 0.415820213110839 no 1368 0.42750526985026 1973 75653 A natural product.
SGTC_33 0986-0033 35.816 µM 0.181906783640221 0.416158860179893 no 1369 0.427827940373335 2081 2848082
SGTC_756 0508-1999 28.3 µM 0.181863667349704 0.416176616934561 no 1370 0.427844859102536 1879 6753853
SGTC_1479 0549-0158 134 µM 0.181758323402902 0.416220001873854 no 1371 0.427886196373098 1977 5440202
SGTC_1426 4048-4480 71.7 µM 0.181548986861157 0.416306218239932 no 1372 0.427968342988574 2065 14224343
SGTC_1374 2889-5571 141 µM 0.181225231311937 0.416439566610653 no 1373 0.428095395385325 1961 2853281
SGTC_1938 st074717 56.4 µM 0.179813606289838 0.41702109863466 no 1374 0.428649450725565 2009 17250979
SGTC_1002 4049-0206 172 µM 0.1785575666016 0.417538688560376 no 1375 0.429142557933847 1959 4662749
SGTC_3243 9134147 49.47 µM 0.17632272957728 0.418459974933706 no 1376 0.430020203076845 2105 24282180
SGTC_2267 7931562 200 µM 0.173825372480281 0.419490011477397 no 1377 0.431001351792142 1849 934880
SGTC_1289 0976-0073 69.1 µM 0.173190958245188 0.419751764229005 no 1378 0.431250665261441 2034 3391136
SGTC_2591 skatole 100 µM 0.173109445703053 0.419785398037369 no 1379 0.431282700223475 1993 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_441 propafenone 146 µM 0.172775814288379 0.419923067558771 no 1380 0.431413824260193 2035 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_757 1066-0008 322 µM 0.171153512714482 0.420592632751052 no 1381 0.432051529762859 2076 6842497
SGTC_1480 1070-0044 41.2 µM 0.170854004620583 0.420716272559769 no 1382 0.432169281885843 2110 3124987
SGTC_2698 st077697 67.5 µM 0.170488149143854 0.420867311814468 no 1383 0.432313126771525 1947 3154499
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.170028747547473 0.421056987011029 no 1384 0.432493764270295 2072 3256 An antibiotic and ribosome inhibitor.
SGTC_2933 9026794 32.47 µM 0.168837479562078 0.421548916425748 no 1385 0.432962238536518 2039 17586027
SGTC_659 k018-0002 107 µM 0.168531205829371 0.421675410776271 no 1386 0.433082698026378 2126 6797879 YHR007C ERG11
SGTC_422 cantharidin 155 µM 0.168055773739189 0.421871785357211 no 1387 0.433269700933413 1907 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1495 4469-0029 237 µM 0.166667887906399 0.42244515484978 no 1388 0.433815686904932 2055 793680
SGTC_1398 3558-0053 112 µM 0.16638482827591 0.422562113908266 no 1389 0.433927056408452 1999 4532369
SGTC_2803 7707263 71.43 µM 0.164228547279673 0.423453303602072 no 1390 0.434775614362061 1986 2199229
SGTC_1924 st058459 75.1 µM 0.163230980870296 0.423865730039535 no 1391 0.435168287058344 2077 688683
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.162962355929605 0.423976802609755 no 1392 0.435274037007425 2135 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1460 k062-0059 9.15 µM 0.162443853577314 0.424191212986976 no 1393 0.435478169625274 2071 1373085
SGTC_3009 9080819 71.4286 µM 0.162004877641266 0.424372755253624 no 1394 0.43565100640559 1985 17027216
SGTC_2730 imipramine 71.33 µM 0.160369407610778 0.425049258880584 no 1395 0.436295043441228 2139 3696 A tricyclic antidepressant.
SGTC_225 nsc-122657 1.016 µM 0.159737119971482 0.42531086064247 no 1396 0.436544079411017 2097 275685
SGTC_2190 6049624 200 µM 0.159516003221333 0.425402352930229 no 1397 0.436631175500717 2095 2265554
SGTC_3354 9151612 71.43 µM 0.15950620616539 0.425406406786933 no 1398 0.436635034552484 2111 27261949
SGTC_405 ebelactone b 50 µM 0.159391269640621 0.425453966173447 no 1399 0.436680308399341 1993 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_92 0063-0024 660.874 µM 0.159078486765353 0.425583397550865 no 1400 0.436803518723821 2159 3594437
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.159041457936108 0.425598720827448 no 1401 0.436818105395417 2045 6708739 YPR165W RHO1
SGTC_2572 astragaloside iv 100 µM 0.159038766939788 0.425599834420396 no 1402 0.436819165456034 1994 45006101 An anti-inflammatory agent.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.158883547060322 0.425664068794757 no 1403 0.436880311785179 2093 4620898
SGTC_1227 3909-8010 46.6 µM 0.158758825652144 0.425715683469022 no 1404 0.436929444833827 2039 15982272
SGTC_3188 9110789 49.47 µM 0.157492878251738 0.426239654683923 no 1405 0.437428210093285 2120 849217
SGTC_1625 st003711 30.1 µM 0.155148136516004 0.427210478432113 no 1406 0.438352267070694 2085 24207034 YER133W GLC7
SGTC_793 0488-0545 106 µM 0.154872799050936 0.427324509010345 no 1407 0.438460799045929 1950 292548
SGTC_1766 st045414 44.774 µM 0.154672056181834 0.427407650181878 no 1408 0.438539930389115 2101 253960
SGTC_2036 5160441 105 µM 0.153084386472638 0.428065324663944 no 1409 0.439165864267061 2055 134534 YIL048W NEO1
SGTC_2506 ethyl hematommate 54.16 µM 0.15198658820967 0.42852019235633 no 1410 0.439598756907686 1945 3940691 An allergen.
SGTC_3284 9108171 64.8615 µM 0.148581371123916 0.429931730064653 no 1411 0.440941986758046 2040 8687505
SGTC_897 1000-0139 31.4 µM 0.148001657736906 0.430172123825565 no 1412 0.441170729983348 2154 6151020
SGTC_2005 4024620 188 µM 0.145807909385071 0.43108205421985 no 1413 0.442036515926152 2116 236743
SGTC_20 0481-0013 4.944 µM 0.145556115087055 0.431186517815888 no 1414 0.442135907000697 2033 182045
SGTC_167 3672-0051 66.205 µM 0.145085267604116 0.431381874393908 no 1415 0.44232177497986 2094 3237971
SGTC_1560 lithocholic acid 53.1 µM 0.144233155021655 0.431735462093313 no 1416 0.442658180369874 2163 9903 A bile acid which acts as a detergent.
SGTC_555 4296-0685 37 µM 0.143343576253648 0.43210465490095 no 1417 0.443009421140242 2154 2908540 YHR072W ERG7
SGTC_941 3237-0776 460 µM 0.143063183684122 0.432221035677133 no 1418 0.443120140478466 2139 760008
SGTC_56 0957-0365 83.25 µM 0.142545511823319 0.432435917918926 no 1419 0.443324566566647 2153 6752360
SGTC_3152 9099253 49.47 µM 0.14208474798299 0.43262719482219 no 1420 0.443506532646418 2099 25236131
SGTC_456 gingerol 170 µM 0.139057125964578 0.433884442319933 no 1421 0.444702503753447 2103 442793 A herb.
SGTC_183 3914-0051 30.55 µM 0.138689389149026 0.434037194195747 no 1422 0.444847801647635 2174 1596232
SGTC_966 1300-0360 30.2 µM 0.138600994806613 0.434073913233323 no 1423 0.444882728578498 2042 70588
SGTC_2858 9025781 8.96 µM 0.138459303327417 0.434132773104856 no 1424 0.444938715503259 2159 4894980 YPL153C RAD53
SGTC_47 0149-0135 24.25 µM 0.138004161045951 0.434321853036339 no 1425 0.445118564488707 2138 5239155
SGTC_962 1254-0300 21.5 µM 0.137919213031705 0.434357144687489 no 1426 0.445152132857723 2065 7340576
SGTC_1441 4106-0040 13 µM 0.137459387210986 0.434548188390498 no 1427 0.445333846136522 2159 2904180
SGTC_594 1487-1584 10.8 µM 0.13667355831118 0.434874711857215 no 1428 0.445644415390466 2030 5013332
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.136089135732366 0.435117576850332 no 1429 0.445875408026631 2134 97141
SGTC_1249 0481-0015 10.2 µM 0.136026908244714 0.435143437798522 no 1430 0.445900004483424 2081 4227577
SGTC_252 miconazole 1.30953 nM 0.13584528502389 0.435218919672875 no 1431 0.445971795293912 2153 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2981 9013952 38.96 µM 0.13544114185797 0.435386888401022 no 1432 0.446131548650687 1923 2996344
SGTC_118 0083-0097 135.343 µM 0.134582043003394 0.435743983095659 no 1433 0.446471170016777 2078 5207356
SGTC_2701 st077767 14.721 µM 0.133742038541365 0.436093191642188 no 1434 0.446803280905422 2066 5721188
SGTC_2352 9027995 87.8 µM 0.13333313333156 0.436263200683957 no 1435 0.446964962459456 2089 2997347
SGTC_777 1315-0167 517 µM 0.131778102002049 0.436909837722288 no 1436 0.447579903776572 2002 4221767
SGTC_2140 5586273 200 µM 0.131587345483445 0.43698917267537 no 1437 0.44765534766185 2180 854421
SGTC_2788 5282734 71.43 µM 0.13111301254055 0.437186457026054 no 1438 0.447842953753797 2154 743706
SGTC_29 0299-0004 12.984 µM 0.126950115372764 0.438918552141804 no 1439 0.449489940577423 2160 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2187 6125751 200 µM 0.126380577408287 0.439155616822869 no 1440 0.449715337926822 2121 874498
SGTC_496 calpeptin 138 µM 0.126351606868246 0.439167676114597 no 1441 0.44972680358962 2066 73364 A calpain inhibitor.
SGTC_3037 9091026 49.47 µM 0.126218121516463 0.439223241524235 no 1442 0.449779633593254 2189 25236398 YIL048W NEO1
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.125987657598858 0.439319178628893 no 1443 0.449870847265949 2184 5355888
SGTC_1261 0712-0010 12.7 µM 0.124604882606688 0.439894872367192 no 1444 0.450418181383252 2162 2840123
SGTC_856 0433-0016 11.3 µM 0.123587262246536 0.440318621740229 no 1445 0.450821039207839 2093 3911780
SGTC_625 k213-0058 121 µM 0.122193504354258 0.44089911015477 no 1446 0.451372885340222 2111 3655420
SGTC_297 0986-0032 24 µM 0.121534144803993 0.441173772182568 no 1447 0.451633985748292 2116 2847425
SGTC_1937 st074714 47.2 µM 0.120995773874678 0.441398056325109 no 1448 0.451847191280842 2168 17250970
SGTC_1550 gossypolone 36.6 µM 0.119459454168499 0.442038186825104 no 1449 0.4524556804204 2196 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_254 nsc-64875 3.808 µM 0.119222204589757 0.442137053934085 no 1450 0.452549657696517 2186 56993
SGTC_718 1130-0073 349 µM 0.118846884128527 0.442293465570351 no 1451 0.452698331857749 2136 6740020
SGTC_3156 9099931 49.47 µM 0.118733439696735 0.442340744352038 no 1452 0.452743271443293 2116 18111053
SGTC_2434 5670830 169.91 µM 0.118642518193504 0.442378637134389 no 1453 0.452779289290836 2097 1549830
SGTC_479 n-linoleoylglycine 10 µM 0.118477690092434 0.442447332848023 no 1454 0.452844585653687 2069 6433346 An anti-infammatory.
SGTC_397 arbidol 50 µM 0.117010960428804 0.443058700471423 no 1455 0.453425683991189 2181 131410 A RNA synthesis inhibitor.
SGTC_2033 5192550 145 µM 0.116726159602541 0.443177427959067 no 1456 0.453538529805747 2097 182073
SGTC_709 3807-1509 243 µM 0.115946165115261 0.443502617381012 no 1457 0.453847603964022 2199 1886677 YPL242C IQG1
SGTC_1877 wortmannin 25 µM 0.114717911501624 0.444014768672924 no 1458 0.454334358166707 2212 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2138 5575593 77.673 µM 0.113997354509359 0.444315266641506 no 1459 0.454619945284772 2145 762213
SGTC_697 0508-1955 564 µM 0.113728824012768 0.444427261634485 no 1460 0.454726381251306 2206 6243113
SGTC_96 0929-0093 37.281 µM 0.11181122630212 0.445227155274492 no 1461 0.455486543021005 2072 6991579
SGTC_2310 7668677 200 µM 0.11133772413387 0.445424703205865 no 1462 0.455674270910422 2150 2197143
SGTC_2049 5262831 67.185 µM 0.111002001919818 0.445564776731286 no 1463 0.455807379620993 2117 763417
SGTC_1758 st042942 75.2445 µM 0.110726052149183 0.445679916463222 no 1464 0.455916793189199 2211 669317
SGTC_2099 5377090 177.372 µM 0.110631886964895 0.445719207829552 no 1465 0.455954130274212 2097 2243829
SGTC_1712 st032288 53.4 µM 0.110352404702988 0.44583582774047 no 1466 0.456064949029701 2161 2883011
SGTC_224 benfluorex 43.875 µM 0.110305060141691 0.445855583728866 no 1467 0.456083722171176 2215 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1044 1222-0021 1.78 µM 0.109808401955436 0.446062837872521 no 1468 0.456280663773539 2129 4306703
SGTC_2742 clothiapine 36.27 µM 0.109740721505251 0.446091081887098 no 1469 0.456307502171085 2209 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2066 5222451 176 µM 0.108875512261851 0.446452170062093 no 1470 0.456650614773883 2210 2281147
SGTC_2427 5545055 42.75 µM 0.108759975056634 0.446500391960278 no 1471 0.456696435357621 2134 5372858
SGTC_1370 2001-0092 44.6 µM 0.108262688941939 0.446707953868387 no 1472 0.45689365926046 2185 790957
SGTC_276 colchicine 750 µM 0.10660862577925 0.447398446883673 no 1473 0.457549737603102 2120 2833 A microtubule depolymerizer.
SGTC_3032 9089427 49.47 µM 0.106338585953567 0.447511190915465 no 1474 0.457656858984818 2126 17173707
SGTC_3227 9130768 49.47 µM 0.105969443885511 0.44766531787567 no 1475 0.457803297947106 2208 17720899
SGTC_3058 9093861 49.47 µM 0.105938643206756 0.447678178363192 no 1476 0.457815516860926 2174 17217477
SGTC_3331 9141060 1.957 µM 0.105917012385527 0.447687210109583 no 1477 0.45782409803138 2083 4906567 YPR165W RHO1
SGTC_161 4065-0411 162.148 µM 0.105908745825585 0.447690661741265 no 1478 0.457827377466382 2142 1906281 YLR208W SEC13
SGTC_2770 toltrazuril 17.5 µM 0.105854913022651 0.447713139266416 no 1479 0.457848733599996 2230 68591 Kills coccidiodes.
SGTC_152 4469-0003 551.229 µM 0.105838269085398 0.447720088864568 no 1480 0.457855336478807 2235 697280
SGTC_2490 carminic acid 95.39 µM 0.105832617885829 0.447722448500165 no 1481 0.457857578390042 2225 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_973 1325-0077 65.9 µM 0.103030259377645 0.448892788246425 no 1482 0.458969477615837 2174 2835149
SGTC_2989 9073649 71.4286 µM 0.102610166990464 0.449068268634019 no 1483 0.459136186672595 2246 21367202
SGTC_2000 st075254 36.4 µM 0.10217112488242 0.449251675318551 no 1484 0.459310423397619 2230 17234175
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.101034339780467 0.449726609413739 no 1485 0.45976160021879 2128 4213774
SGTC_3092 9117248 49.47 µM 0.0988207659253552 0.450651617963082 no 1486 0.460640290185531 2257 17141857
SGTC_134 0269-0018 6.916 µM 0.098453306805532 0.450805197913008 no 1487 0.460786173764989 2118 4378915
SGTC_255 tunicamycin 200.472 nM 0.098269288472279 0.450882111350455 no 1488 0.460859232184096 2228 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_477 mead ethanolamide 10 µM 0.0969540750776939 0.451431879579406 no 1489 0.461381432668505 2236 16061185
SGTC_2395 5646831 180.19 µM 0.0964697827178596 0.451634340636322 no 1490 0.461573735933694 2191 6808628
SGTC_1039 k821-0043 94 µM 0.095176897262289 0.452174899919467 no 1491 0.4620871599921 2221 15992768
SGTC_3230 9131665 49.47 µM 0.0948835912834625 0.452297544403285 no 1492 0.462203644985191 2185 15943720
SGTC_2636 apigenin dimethyl ether 100 µM 0.094710602934239 0.45236988078394 no 1493 0.462272347957782 2164 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2682 pyrogallin 40.03 µM 0.0946740765997434 0.452385154747952 no 1494 0.462286854672709 2243 822798 An ATP competetive kinase inhibitor.
SGTC_1129 3453-1384 223 µM 0.0921186103513323 0.453453929988173 no 1495 0.463301901199138 2166 1084452
SGTC_3287 9117173 37.0625 µM 0.0911930754113068 0.453841100994568 no 1496 0.463669588524819 2268 2789709
SGTC_2344 7990960 76.95 µM 0.0891893220121498 0.454679463599778 no 1497 0.464465725678818 2151 140813
SGTC_99 0109-0120 622.8 µM 0.0891774961820844 0.454684412083973 no 1498 0.464470424777659 2237 759414
SGTC_1726 st035556 14.5795 µM 0.0891773056305095 0.454684491819783 no 1499 0.464470500495064 2227 5919439
SGTC_330 1488-0319 80.1 µM 0.0859583578253017 0.456031710124743 no 1500 0.465749760146631 2149 6846614
SGTC_3168 9103419 49.47 µM 0.0851448637603603 0.456372260448961 no 1501 0.466073111829154 2255 16649256
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.0846496927089991 0.456579567972466 no 1502 0.466269945870487 2240 140250 A respiratory chain inhibitor.
SGTC_3172 9105863 49.47 µM 0.0840664611959171 0.456823757902716 no 1503 0.466501795154842 2249 2348785
SGTC_2924 9010168 62.78 µM 0.0836685183055544 0.45699037974224 no 1504 0.46665999405226 2174 2993929
SGTC_833 3852-0053 558 µM 0.0829580626351004 0.457287871939114 no 1505 0.466942442895206 2217 3123681
SGTC_138 0850-0259 40.9225 µM 0.0825887756485316 0.457442514551958 no 1506 0.467089263259048 2278 6813004
SGTC_885 0865-0106 16.8 µM 0.0823532674052307 0.457541139346864 no 1507 0.467182898483851 2234 2793380
SGTC_2040 5100729 123 µM 0.0819414676703576 0.457713596763681 no 1508 0.467346629431179 2197 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2782 7736369 71.43 µM 0.0818124305503359 0.45776763779821 no 1509 0.467397935531707 2160 2950836 YOL077C BRX1
SGTC_2228 7354201 200 µM 0.0814801713193659 0.457906792298654 no 1510 0.467530046717336 2199 753451
SGTC_1759 st043059 70 µM 0.0795205867648526 0.458727596266433 no 1511 0.46830927879592 2206 669426
SGTC_191 3914-0123 66.505 µM 0.0780094666302774 0.459360673967984 no 1512 0.468910261330375 2167 3144412
SGTC_645 0845-0943 5.41 µM 0.0766514189599556 0.459929710558719 no 1513 0.469450426413619 2185 1885106
SGTC_1422 4031-0024 15.5 µM 0.0761849286538191 0.460125194017729 no 1514 0.469635986515554 2266 782427
SGTC_1282 0886-0010 32.4 µM 0.0759731362575608 0.460213949121762 no 1515 0.469720235287035 2263 2836211 YNL267W PIK1
SGTC_525 k781-2675 26.7 µM 0.0753638775522746 0.460469280090298 no 1516 0.469962599491243 2292 3651118 YDL195W SEC31
SGTC_1116 jasmonic acid 1.58368 µM 0.0742549571060885 0.460934053383678 no 1517 0.470403758529513 2257 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2846 9008642 19.48 µM 0.0741491363646778 0.460978408016122 no 1518 0.470445858836741 2149 2992898
SGTC_2756 carbadox 75.1 µM 0.0738637094653582 0.461098046765814 no 1519 0.470559416293979 2210 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1534 6-azauridine 81.6 µM 0.0737304080730168 0.461153922215592 no 1520 0.470612451244257 2276 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2027 5150920 200 µM 0.073583190506746 0.461215631747443 no 1521 0.470671023453501 2246 786715
SGTC_1384 3089-0840 101 µM 0.0734130413863305 0.461286954715838 no 1522 0.47073872003681 2262 1069836
SGTC_3125 9127534 49.47 µM 0.0733150542272524 0.461328029457792 no 1523 0.470777706198898 2294 1639235
SGTC_1742 st038235 28.8875 µM 0.0718979767872802 0.461922092891776 no 1524 0.471341550087185 2194 564103 YBR002C RER2
SGTC_3129 9127257 49.47 µM 0.0712449186919964 0.462195894848174 no 1525 0.471601416136968 2092 837894
SGTC_1086 cerivastatin 2.18 µM 0.0705956258955267 0.462468135921716 no 1526 0.471859795879215 2300 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3050 9093513 49.47 µM 0.0687877285989876 0.463226258904662 no 1527 0.472579293054701 2266 25236664
SGTC_2666 tannic acid 100 µM 0.0686990894561284 0.463263432267514 no 1528 0.472614571501012 2279 16134267 A thiamine antagonist.
SGTC_2841 9004761 38.96 µM 0.0680831567924123 0.463521750109382 no 1529 0.472859719087648 2196 2991039
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0676108362324263 0.463719848466756 no 1530 0.47304771453713 2271 688667
SGTC_1417 3966-0327 90.4 µM 0.0663609983063179 0.464244092586295 no 1531 0.47354521028433 2228 651118
SGTC_3233 9132340 49.47 µM 0.0660813084767739 0.464361416929275 no 1532 0.473656545997572 2265 17682950
SGTC_3167 9103034 49.47 µM 0.0659080079367118 0.464434114628407 no 1533 0.473725532518121 2270 5127859
SGTC_1776 st049249 45.9 µM 0.0641662372109733 0.465164834109024 no 1534 0.474418930387466 2230 1822314
SGTC_2489 cantharidin 73.42 µM 0.0629096710190181 0.465692070382487 no 1535 0.474919216870642 2286 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1596 piperlongumine 63 µM 0.062627464494569 0.465810488309803 no 1536 0.475031579418299 2294 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1437 4092-1038 11.6 µM 0.0606087857144292 0.466657642690036 no 1537 0.475835388200763 2284 3977136
SGTC_748 act1.228 77.9 µM 0.0597842165530319 0.467003723280832 no 1538 0.476163748228027 2264 4421505 YNR035C ARC35
SGTC_2699 st077704 54.6 µM 0.059340128229735 0.467190122303226 no 1539 0.476340599852536 2251 645852
SGTC_979 1426-2828 121 µM 0.0589802856206887 0.467341165803942 no 1540 0.476483905283752 2252 747872
SGTC_2357 9067248 200 µM 0.0584086248433122 0.467581129385993 no 1541 0.476711572435736 2229 9150235
SGTC_2731 amoxapine 43.43 µM 0.0580502059008586 0.467731587376167 no 1542 0.476854318697598 2316 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3149 9097855 49.47 µM 0.0557900857123174 0.468680451535755 no 1543 0.477754516549642 2297 25236625 YMR079W SEC14
SGTC_2603 homopterocarpin 100 µM 0.0555617068004388 0.468776341630308 no 1544 0.477845485451079 2259 101795 A weak amylase inhibitor.
SGTC_154 3389-1638 511.116 µM 0.0552639535170915 0.46890136285626 no 1545 0.477964089592787 2081 5238686
SGTC_1634 st006576 41 µM 0.0539146750129592 0.469467938784264 no 1546 0.478501572350995 2300 3915356
SGTC_1393 3470-5649 58.2 µM 0.0532701273073594 0.469738612891164 no 1547 0.478758340675173 2255 4108395
SGTC_2147 5545932 89.7195 µM 0.0531038776057785 0.469808430772211 no 1548 0.478824570965862 2260 797404
SGTC_2 0422-0095 29 µM 0.0520914288096959 0.470233636637248 no 1549 0.479227921257157 2238 6790840
SGTC_1302 1159-0335 255 µM 0.052067356867905 0.47024374672979 no 1550 0.479237511557976 2283 649284
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.0501811024063475 0.471036023084191 no 1551 0.479989035337089 2314 65057 A dermal irritant. YDR527W RBA50
SGTC_1194 1488-0194 225 µM 0.0494582204174256 0.471339683041638 no 1552 0.480277065852383 2284 1391452
SGTC_903 1134-0042 114 µM 0.049427737722576 0.471352488229113 no 1553 0.48028921183302 2299 701009
SGTC_2342 7990637 118.86 µM 0.0489960493954541 0.471533835276031 no 1554 0.480461222142987 2267 2033102 YER133W GLC7
SGTC_2409 alverine citrate 63.97 µM 0.0486072289749099 0.471697179086968 no 1555 0.480616154443976 2264 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_934 2950-0684 338 µM 0.048448133538025 0.471764016598254 no 1556 0.480679549650516 2319 1121253
SGTC_2433 5607874 27.82 µM 0.0481495739748939 0.471889446464777 no 1557 0.480798518837641 2319 2252428
SGTC_1965 Pectolinarigenin 58.4 µM 0.0470410992873112 0.472355159516097 no 1558 0.481240235637152 2313 5320438 An anti-inflammatory.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.0466555388245452 0.472517157258089 no 1559 0.481393883303641 2314 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_248 streptozotocin 5.23457 mM 0.0462211582680417 0.472699672778727 no 1560 0.481566989318079 2323 5300 DNA alkylating agent.
SGTC_2070 5230947 200 µM 0.0452491455791095 0.473108108180206 no 1561 0.481954360916234 2321 2835538
SGTC_688 0527-0193 473 µM 0.0448013463257163 0.473296280970793 no 1562 0.482132825979659 2279 4007154
SGTC_1071 trifluoperazine 6.31 µM 0.0437529117226658 0.473736874090229 no 1563 0.482550681056168 2298 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1749 st037932 54.2 µM 0.0428178744597822 0.474129840343991 no 1564 0.482923357648797 2252 594497
SGTC_233 rapamycin 362 pM 0.042809235694151 0.474133471058817 no 1565 0.482926800860507 2327 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1909 st060837 51.5 µM 0.0423456208558388 0.474328323019979 no 1566 0.483111588848457 2274 678937
SGTC_2212 7123476 200 µM 0.0422413167754575 0.474372161668019 no 1567 0.483153162956904 2312 1085715
SGTC_1132 3456-3614 2.5 µM 0.0418632763837654 0.474531053347623 no 1568 0.483303845959451 2325 3125502
SGTC_3341 9147222 25.867 µM 0.0414204099927883 0.47471719676916 no 1569 0.483480370968583 2274 1939759
SGTC_1049 3226-0134 66 µM 0.0410933288193496 0.474854677463647 no 1570 0.483610746472 2317 5702385
SGTC_864 0469-0573 172 µM 0.0407618115263067 0.474994025829499 no 1571 0.483742892013662 2305 689425
SGTC_2112 5488546 200 µM 0.0402574101417348 0.475206049315272 no 1572 0.483943954008192 2340 600757
SGTC_2811 7967822 32.47 µM 0.0401865230286258 0.475235847047418 no 1573 0.483972211008314 2314 2232244
SGTC_720 r052-1644 49.9 µM 0.039385602380851 0.47557252740101 no 1574 0.484291479319587 2299 1422863 YOR257W CDC31
SGTC_1020 4335-0961 93.3 µM 0.0373065030581178 0.476446592292706 no 1575 0.485120310206691 2296 669075
SGTC_686 1319-0111 510 µM 0.0365559415384537 0.476762160583622 no 1576 0.48541953679447 2332 4562600
SGTC_2143 5623677 140.463 µM 0.0362266448903019 0.476900615645266 no 1577 0.48555082018981 2340 5375313
SGTC_171 k064-0041 9.68 µM 0.0346282262824194 0.477572721159857 no 1578 0.486188096836986 2288 53325
SGTC_839 0122-0028 230 µM 0.034203363021313 0.477751379127933 no 1579 0.486357492404216 2325 759448
SGTC_275 trichlorophene 5.69 µM 0.0335321253561552 0.478033648351726 no 1580 0.486625123950086 2276 62616
SGTC_337 1315-0038 354 µM 0.0331586554478969 0.47819070489857 no 1581 0.48677403407536 2332 1626437
SGTC_97 0535-0701 19.132 µM 0.0330758668611536 0.478225520718702 no 1582 0.486807043836196 2335 2832013 YGL099W LSG1
SGTC_2311 7694451 200 µM 0.0326216090762827 0.478416556732201 no 1583 0.486988168724398 2315 2163142
SGTC_105 0111-0055 734.78 µM 0.0315910270756167 0.478849981551583 no 1584 0.487399099588133 2292 5179370
SGTC_2630 antimycin a 100 µM 0.0313621289001901 0.478946251103456 no 1585 0.487490371521844 2344 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2948 9070189 9.45 µM 0.0305228403142379 0.479299247939475 no 1586 0.487825038964511 2345 6473636 YDL196W YDL196W
SGTC_2114 5491910 81.25 µM 0.0305146971212978 0.479302672969338 no 1587 0.487828286115929 2340 2849228
SGTC_235 0330-0087 5 mM 0.0303521297177998 0.47937104919685 no 1588 0.487893111099365 2338 46494818 YHR062C RPP1
SGTC_3036 9090181 49.47 µM 0.0297988097481562 0.479603781398802 no 1589 0.488113754014967 2349 25236586
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0294181404625959 0.479763898948537 no 1590 0.488265552534345 2351 77254
SGTC_2843 9000894 45.46 µM 0.0284264851963885 0.480181025387718 no 1591 0.488661000300764 2352 2242070
SGTC_1502 4534-4282 27.7 µM 0.0282528860224145 0.480254049788644 no 1592 0.488730228545526 2336 3278949
SGTC_2889 9059656 51.95 µM 0.0280755983602637 0.480328626434114 no 1593 0.488800928043809 2332 3949838
SGTC_98 0074-0023 107.663 µM 0.0280392371476286 0.480343921984471 no 1594 0.488815428360312 2286 3563821
SGTC_2555 cholic acid 100 µM 0.0268743539009625 0.480833951922033 no 1595 0.489279974374919 2311 6708657 Influences liver metabolism.
SGTC_1662 st014054 52 µM 0.0265060761144592 0.480988880925898 no 1596 0.489426843632293 2353 2838777
SGTC_3065 9113888 49.47 µM 0.0257600061075473 0.481302750291526 no 1597 0.489724380878518 2342 16648368
SGTC_2511 berberine 10.47 µM 0.025624738588249 0.481359658169291 no 1598 0.489778327003287 2352 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1136 pergolide 1.05886 µM 0.0253882480962244 0.481459152086465 no 1599 0.489872642374355 2320 47811 A dopamine receptor agonist.
SGTC_853 0419-0306 21 µM 0.0253111095708176 0.481491605286315 no 1600 0.489903406307444 2337 762713
SGTC_1520 flindersine 88 µM 0.0246625141033066 0.481764482824872 no 1601 0.490162077695627 2358 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1404 3909-7820 48.3 µM 0.0236179449937908 0.482203972576513 no 1602 0.49057867905423 2358 23741373
SGTC_2818 7996756 12.99 µM 0.0234412152892695 0.482278331604471 no 1603 0.490649164490955 2358 2241621
SGTC_3197 9113331 49.47 µM 0.0232164976553709 0.48237288244499 no 1604 0.490738789464214 2332 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2284 7945075 39.21 µM 0.0217718589604117 0.482980743380555 no 1605 0.491314971080497 2357 1245402
SGTC_1933 st074711 15.9 µM 0.021738533291546 0.482994766301713 no 1606 0.491328262953012 2370 17250958
SGTC_1945 st075991 56.6 µM 0.0210984961381123 0.483264088004459 no 1607 0.491583542268425 2316 1084980
SGTC_587 k089-0003 57 µM 0.0206823792479952 0.48343919023956 no 1608 0.49174951266873 2360 9659696
SGTC_1600 coumarin 106 71.1 µM 0.0205920546757866 0.4834771992964 no 1609 0.49178553928694 2341 100336 A hepatotoxic, DNA x-linker.
SGTC_8 0354-0001 70 µM 0.0203993097675021 0.483558307873015 no 1610 0.491862417231198 2363 4993152
SGTC_1462 k081-0014 26.5 µM 0.0202256727089659 0.483631376298498 no 1611 0.491931674106132 2352 3270634
SGTC_2877 9040724 71.43 µM 0.0186720009139309 0.484285203025906 no 1612 0.492551382197097 2374 6463895
SGTC_2476 5806916 10.51 µM 0.0174750966392446 0.484788921327098 no 1613 0.493028799907999 2351 2870194
SGTC_451 chloral hydrate 100 µM 0.0173845046340164 0.484827048056843 no 1614 0.493064935399777 2359 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_618 k072-0232 33.2 µM 0.0173785685226418 0.484829546345213 no 1615 0.49306730320788 2355 5872756 YGL099W LSG1
SGTC_1725 st036284 20.55 µM 0.0169669748086679 0.485002772269044 no 1616 0.493231481131418 2374 707914
SGTC_2879 9041815 71.43 µM 0.0152278793544041 0.485734729795972 no 1617 0.493925189865159 2378 4942971
SGTC_812 4251-0442 148 µM 0.0150965148125874 0.48579002101881 no 1618 0.493977590711378 2376 5723007
SGTC_3191 9110352 49.47 µM 0.0149132791948718 0.485867145189002 no 1619 0.494050682917752 2386 17122424
SGTC_1847 st056231 15 µM 0.014676735249665 0.485966707702421 no 1620 0.494145039970869 2371 5393180
SGTC_1372 2752-0194 270 µM 0.0146625660123685 0.485972671632128 no 1621 0.494150692070513 2381 823334
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.0146404077950975 0.485981998184896 no 1622 0.494159530971484 2367 115019
SGTC_1012 4112-3522 18 µM 0.0142116790076175 0.486162454713576 no 1623 0.494330551213825 2386 3112398
SGTC_529 4076-0302 30.3 µM 0.0133815276743974 0.486511882304566 no 1624 0.494661702152099 2363 5816522
SGTC_424 splitomicin 100 mM 0.0121186237474841 0.487043484040839 no 1625 0.495165486940745 2328 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1853 st056710 91.2 µM 0.0115658973640894 0.487276153776551 no 1626 0.49538597740053 2387 269167
SGTC_177 1327-0068 8.361 µM 0.0110039833109532 0.487512695493665 no 1627 0.495610134397692 2388 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1809 st050081 57.6 µM 0.0109730315938294 0.487525724967536 no 1628 0.495622481600835 2375 5036894
SGTC_368 fentichlor 4.58 µM 0.0104936575418388 0.487727524564416 no 1629 0.495813713160767 2366 7329 A pesticide.
SGTC_213 1246-0773 967 nM 0.00934412825447974 0.488211448622602 no 1630 0.496272286412017 2355 6251622
SGTC_514 4466-0038 2.65 nM 0.00876033437581474 0.488457218431783 no 1631 0.496505176927892 2348 5722064
SGTC_3073 9114972 49.47 µM 0.00708965117701307 0.489160578742994 no 1632 0.497171662085742 2393 41905075
SGTC_1007 4101-0031 70 µM 0.00664668518366523 0.489347073881871 no 1633 0.497348375779829 2395 1146276
SGTC_3265 9137266 49.47 µM 0.00374061657593559 0.490570627007613 no 1634 0.498507713373155 2396 17224265
SGTC_2829 7992743 58.44 µM 0.00365417425477724 0.490607023563093 no 1635 0.49854219863415 2402 16462845
SGTC_1796 st049173 110.4 µM 0.00332538516360015 0.490745460983279 no 1636 0.498673365704649 2399 94134
SGTC_1512 0259-0544 12.2 µM 0.00331587807642943 0.490749463981358 no 1637 0.498677158462774 2394 18476
SGTC_683 panaxydol 45 µM 0.00324781078474596 0.490778124021121 no 1638 0.498704313237098 2396 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2946 9065502 71.43 µM 0.00288278436942782 0.490931820846115 no 1639 0.498849937022678 2402 16489101
SGTC_2969 9091408 28.7 µM 0.00261557383631332 0.491044332491485 no 1640 0.498956538198943 2397 4286311
SGTC_62 0180-0423 3.232 µM 0.00135103823307622 0.491576787263867 no 1641 0.499461013890356 2402 30102 YGL099W LSG1
SGTC_3204 9114183 49.47 µM 0.00116473131241301 0.491655236333844 no 1642 0.499535339539231 2401 17027248
SGTC_911 3456-4043 236 µM 0 0.49214568203814 no 1643 0.5 2406 914281
SGTC_1295 1013-0063 9.78 µM -0.00077005465108966 0.492469943642165 no 1644 0.499692792671822 2408 6826038
SGTC_1148 3909-7663 27.7 µM -0.00208861779858506 0.493025187620693 no 1645 0.499166762658354 2409 4084526
SGTC_3308 9128332 17.569 µM -0.00214530462960751 0.493049058628529 no 1646 0.499144147935395 2410 17332805 YDL196W YDL196W
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.00254183258373514 0.493216038523422 no 1647 0.498985956604587 2415 165521
SGTC_806 3966-4455 5.86 µM -0.0029293143521586 0.493379210173058 no 1648 0.498831374323644 2416 714982
SGTC_3063 1327-0034 4 µM -0.00293843702870099 0.493383051818047 no 1649 0.498827734917924 2404 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_7 0192-1582 4.227 µM -0.0034959517485439 0.493617827667224 no 1650 0.498605319878152 2412 252616
SGTC_1179 1021-1431 9.29 µM -0.00485658602329643 0.494190815498838 no 1651 0.498062510113314 2417 2840958
SGTC_2621 lithochol-11-enic acid 100 µM -0.00508094084547816 0.494285296576269 no 1652 0.497973006593987 2413 6708711
SGTC_1731 st035964 63 µM -0.00553496496640223 0.494476497757108 no 1653 0.497791879728969 2426 6739575
SGTC_1661 st013063 9.66 µM -0.00627171765406742 0.494786765856379 no 1654 0.497497963059768 2416 721395
SGTC_1696 st025591 34.7925 µM -0.00718203109726552 0.495170129799889 no 1655 0.497134808768008 2419 2787147
SGTC_230 MPP+ 141.667 µM -0.00786687061929611 0.495458541967989 no 1656 0.496861605066865 2427 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1001 4048-4355 44.4 µM -0.00805689562392899 0.495538569206991 no 1657 0.496785798461086 2420 21824233
SGTC_868 0527-0199 213 µM -0.00907174987927449 0.495965968468851 no 1658 0.496380945055346 2438 2849450
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.0102839217413768 0.496476472782769 no 1659 0.495897381123996 2432 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2179 6298986 200 µM -0.0108049931575198 0.496695923029757 no 1660 0.495689515263504 2435 738374
SGTC_2624 nerol 100 µM -0.0109377996596807 0.496751854910657 no 1661 0.495636536265533 2426 637566 A natural product oil.
SGTC_2300 7976697 71.57 µM -0.0117409405171501 0.497090101559094 no 1662 0.495316150027484 2434 2236109
SGTC_2466 5983409 37.09 µM -0.0126251340468419 0.497462486341408 no 1663 0.494963434033075 2447 2879657
SGTC_1523 st012844 44.7 µM -0.0140609458025264 0.49806719387188 no 1664 0.494390679054206 2468 4274103
SGTC_1866 st057638 64 µM -0.0144849562098968 0.498245771317331 no 1665 0.49422154060572 2439 688802
SGTC_2566 crystal violet carbinol 226 nM -0.0144868609087806 0.498246573506624 no 1666 0.494220780820525 2478 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_482 fipronil 114 µM -0.0150422968103051 0.498480503020198 no 1667 0.493999218109055 2433 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2098 5376439 882.5 nM -0.0160238440770632 0.49889389645701 no 1668 0.493607684656564 2462 2844116
SGTC_2243 6634756 200 µM -0.0168354112491598 0.499235701129357 no 1669 0.493283959902004 2440 885676
SGTC_2447 5741742 33.78 µM -0.0175539399802796 0.499538321630128 no 1670 0.492997350789749 2455 1776504
SGTC_2749 bexarotene 57.39 µM -0.0175699490550605 0.499545064125808 no 1671 0.492990965077772 2449 82146 An retinoic acid receptor inhibitor.
SGTC_2015 5119600 184 µM -0.017678199015817 0.499590655451712 no 1672 0.492947786297953 2446 2828786
SGTC_519 k048-0011 62.8 µM -0.0178078545129608 0.499645262093048 no 1673 0.492896069379564 2501 6836379
SGTC_2990 9074105 71.4286 µM -0.0180353354430591 0.499741069612481 no 1674 0.492805332191575 2438 6502001
SGTC_1852 st056254 31.4 µM -0.0185947808622987 0.499976689757441 no 1675 0.492582183193013 2469 442583
SGTC_2026 5148700 152 µM -0.0186501276045113 0.5 no 1676 0.492560106865785 2448 79838
SGTC_2370 9071495 200 µM -0.0204650873124447 0.499235598637375 no 1677 0.491836181264423 2477 21791103
SGTC_439 amiodarone 34.4 µM -0.0216277344669337 0.498745931175648 no 1678 0.49137245489892 2491 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_801 0866-0028 10.1 µM -0.0216413434323833 0.498740199551733 no 1679 0.491367026977636 2444 6849771
SGTC_3275 9138069 49.47 µM -0.0216803455427974 0.498723773217935 no 1680 0.491351471036559 2516 17617007
SGTC_1963 st076565 50.3 µM -0.0221110267846065 0.498542385392749 no 1681 0.491179695262551 2441 4914280
SGTC_1338 1486-1223 76 µM -0.0224974160337344 0.498379652055889 no 1682 0.491025586592967 2489 3444526
SGTC_1138 3761-0006 1.03 µM -0.0237113929663862 0.497868370256159 no 1683 0.490541409144302 2432 12061087
SGTC_472 calcifediol 10 µM -0.0240427329907587 0.497728822770547 no 1684 0.490409261275049 2485 5283731 A vitamin D metabolite.
SGTC_1920 st075728 45.7 µM -0.0247686624075118 0.497423090629291 no 1685 0.490119743581196 2443 3400306
SGTC_2878 9043973 25.97 µM -0.0250378433883887 0.497309722850706 no 1686 0.490012389201421 2542 6465167
SGTC_3322 9139058 2.11 µM -0.0253701888394287 0.497169753137974 no 1687 0.489879844655558 2540 4908926 YPR165W RHO1
SGTC_2203 7227154 166.4 µM -0.0257727863411467 0.497000196729566 no 1688 0.489719283995192 2460 896304
SGTC_2252 omeprazole 400 µM -0.0261010881129368 0.496861930823462 no 1689 0.489588354585414 2511 4594 A proton pump inhibitor.
SGTC_1011 4112-3381 17.4 µM -0.0268320600593756 0.496554079770972 no 1690 0.48929684109418 2557 2877139
SGTC_1658 st012944 20 µM -0.0273344463240411 0.496342499450465 no 1691 0.489096491466181 2477 24207260
SGTC_3352 9151559 45.5865 µM -0.0273955403417551 0.496316769731908 no 1692 0.489072127603499 2478 17159339
SGTC_1834 st055981 52.8 µM -0.0279976785723251 0.49606318031881 no 1693 0.488832001326665 2491 471719 YDL150W RPC53
SGTC_362 0310-0100 9.03 µM -0.0291291251134266 0.495586678064259 no 1694 0.488380803583893 2488 790235
SGTC_1423 4048-0112 5.59 µM -0.0292252826988 0.495546182126614 no 1695 0.488342458582722 2464 X1423
SGTC_438 sphingosine 6.67 µM -0.0292285162849444 0.495544820330496 no 1696 0.488341169119346 2463 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_282 k297-0036 65.7 µM -0.0297913341558714 0.495307795382186 no 1697 0.488116735021318 2461 5061378
SGTC_3238 9133470 49.47 µM -0.0300774004591575 0.495187322135233 no 1698 0.488002662198188 2465 3534688
SGTC_950 1165-0508 94.1 µM -0.0302719273497005 0.495105399817489 no 1699 0.487925092519034 2489 6148369
SGTC_2346 9031566 143.75 µM -0.0307868967959847 0.494888528541454 no 1700 0.487719745154859 2500 4771086
SGTC_3060 1327-0027 12.5 µM -0.0311970232765512 0.494715811307612 no 1701 0.487556206920823 2467 16000455 YPR107C YTH1
SGTC_1298 1079-1278 263 µM -0.0317910106046593 0.494465666219865 no 1702 0.487319357756388 2466 2840950
SGTC_2151 5563267 85.4165 µM -0.0320548615141179 0.494354551731998 no 1703 0.487214150094036 2478 5310824
SGTC_374 0880-0231 82.3 µM -0.0338961764546667 0.493579138740299 no 1704 0.48647997109247 2479 6833587
SGTC_209 4077-0173 175.592 µM -0.0339504457782546 0.493556285242289 no 1705 0.486458333218683 2530 15993494
SGTC_2932 9016711 44.54 µM -0.0341079146653649 0.493489973223847 no 1706 0.486395548584194 2468 7117328
SGTC_666 0272-0154 136 µM -0.0344928396926562 0.493327877484596 no 1707 0.48624207602498 2489 6870312
SGTC_333 3486-0131 40.1 µM -0.0346879637452667 0.49324570923367 no 1708 0.486164279346221 2527 6744690
SGTC_2484 5809818 12.04 µM -0.0363663709291932 0.492538931158878 no 1709 0.485495114271862 2499 2870548
SGTC_260 nsc-65238 3.989 µM -0.0363942948446601 0.492527172576539 no 1710 0.485483981610984 2464 3246252
SGTC_2069 5228469 200 µM -0.0365826779963637 0.492447845805514 no 1711 0.485408877620699 2517 2835210
SGTC_992 3909-8734 162 µM -0.036975935424302 0.492282248937403 no 1712 0.485252096682642 2493 4288319
SGTC_1638 st008370 60.6 µM -0.0370615974097742 0.492246177686074 no 1713 0.485217945902771 2455 24207134
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.0370981385783963 0.492230790650404 no 1714 0.485203378103831 2497 676296 Flavone; oxidizing agent.
SGTC_69 0096-0274 206.684 µM -0.0373055402331358 0.49214345658989 no 1715 0.485120694051087 2698 6741392
SGTC_2227 7312221 64.1025 µM -0.0378251313483757 0.49192466538936 no 1716 0.484913553394328 2484 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2491 paeonol 100 µM -0.0384646226793512 0.491655389538738 no 1717 0.484658618805222 2468 11092 Increases levels of cortical cytochrome oxidase.
SGTC_340 k038-0059 454 µM -0.0397004931254051 0.491135002335352 no 1718 0.48416595426556 2471 23733424
SGTC_1685 st024049 53.0905 µM -0.0398966505119141 0.491052407830723 no 1719 0.484087760741512 2519 1941139
SGTC_2457 5731572 11.68 µM -0.0412847385637312 0.49046794727901 no 1720 0.483534449779721 2476 2865357
SGTC_689 0833-0039 98 µM -0.0414573480611464 0.490395270699482 no 1721 0.483465647458252 2507 5374726
SGTC_149 3970-0822 46.1 µM -0.0415390226325305 0.490360882039452 no 1722 0.483433092062388 2486 3114250 YBL034C STU1
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.0421492447805188 0.490103953413873 no 1723 0.483189861683995 2543 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_124 0136-0217 7.121 µM -0.0425178755904191 0.489948746662077 no 1724 0.483042930987382 2500 3976905
SGTC_909 3448-9333 149 µM -0.0425848088957293 0.489920565509836 no 1725 0.483016252625012 2491 3344074
SGTC_2495 cafestol 54.53 µM -0.0432069823204695 0.489658612188965 no 1726 0.482768269600679 2640 16667697 An anti-infammatory.
SGTC_670 4204-0025 119 µM -0.044483276337255 0.489121268933826 no 1727 0.482259591165244 2542 719039
SGTC_545 4218-0007 221 µM -0.046582550150196 0.488237479451937 no 1728 0.481422969947128 2538 2840508
SGTC_3242 9133940 49.47 µM -0.0468582308013287 0.488121422724369 no 1729 0.481313109246992 2609 17248444
SGTC_1182 1222-0449 220 µM -0.0473799549053605 0.487901788771862 no 1730 0.481105202372045 2524 658318
SGTC_2852 9023854 51.95 µM -0.0475836373797131 0.487816044086264 no 1731 0.481024036368207 2535 19798528
SGTC_1840 st055363 71 µM -0.0478981506432869 0.487683643812849 no 1732 0.480898706636869 2542 676033
SGTC_746 1095-0025 46.6 µM -0.0492465948530089 0.487116006429138 no 1733 0.480361389483077 2501 6749286
SGTC_2691 st077356 60.2 µM -0.0511757403560909 0.486303964286622 no 1734 0.479592741449722 2571 2839272
SGTC_733 4069-0007 56.1 µM -0.05167274974663 0.486094765404209 no 1735 0.479394725387368 2491 5717425 YNL287W SEC21
SGTC_2361 9034121 116 µM -0.0520831047586795 0.485922043561527 no 1736 0.479231237571281 2529 6496917
SGTC_2524 avocatin b 10.57 µM -0.054014388685835 0.485109186070503 no 1737 0.478461850231892 2524 6710748
SGTC_1346 1488-2224 62.4 µM -0.0563342848956999 0.484132847776002 no 1738 0.477537753396791 2482 3722427
SGTC_1506 4226-2149 212 µM -0.0576211668259309 0.483591298627561 no 1739 0.477025194497179 2575 991114
SGTC_151 3013-0144 2.285 µM -0.0582834857181587 0.483312591527969 no 1740 0.476761410819959 2702 906558 YHR107C CDC12
SGTC_2522 biochanin a 4.94 µM -0.0585464285420999 0.483201946127199 no 1741 0.476656690631693 2538 5280373 A possible chelator.
SGTC_449 xestospongin c 11.1929 µM -0.0610837206212722 0.482134330417342 no 1742 0.475646267000534 2572 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_3249 9135183 49.47 µM -0.0631850803298921 0.481250238502495 no 1743 0.474809562605474 2658 4902779
SGTC_1651 st011928 86.1 µM -0.0636775947808854 0.481043039158967 no 1744 0.474613472653668 2598 720198
SGTC_2028 5153890 36.43 µM -0.0643282728161181 0.480769308734041 no 1745 0.474354420809605 2519 2830968 YPR165W RHO1
SGTC_1822 st052468 42 µM -0.0644339236792746 0.480724863863383 no 1746 0.474312359474299 2541 2873678
SGTC_2442 5158906 48.48 µM -0.0655395125214001 0.480259782726416 no 1747 0.473872223751554 2615 1893835
SGTC_3270 9137563 49.47 µM -0.0660942810636259 0.480026421801606 no 1748 0.473651381973699 2659 17015724
SGTC_3130 9127414 49.47 µM -0.0663809278680086 0.479905847772968 no 1749 0.473537277032202 2509 1494646
SGTC_2400 5203494 178.7 µM -0.0684512511952468 0.479035050065147 no 1750 0.472713212456635 2531 6777674
SGTC_2030 5175110 200 µM -0.0713289018303459 0.477824849893652 no 1751 0.471567996735972 2615 2831986
SGTC_2129 girgensonine 121.053 µM -0.0725006907606431 0.477332110295963 no 1752 0.471101727884976 2589 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3201 9113999 49.47 µM -0.0728218361473223 0.477197074034228 no 1753 0.470973947177541 2682 16649224
SGTC_2983 9022671 12.99 µM -0.0749024041538703 0.47632229411142 no 1754 0.470146181847405 2730 6405161
SGTC_292 k038-0015 474 µM -0.0751491415466527 0.476218560255247 no 1755 0.470048024515897 2617 46368540
SGTC_549 1661-1316 519 µM -0.0751730111670929 0.476208525024359 no 1756 0.470038528774613 2555 2857282
SGTC_576 1073-0113 22.7 µM -0.075954433426665 0.475880008991901 no 1757 0.469727675140222 2555 5439563
SGTC_3355 9151058 44.0485 µM -0.076158906623255 0.475794049557313 no 1758 0.469646337730458 2540 17015728
SGTC_2377 9073351 62.6 µM -0.076314693556083 0.475728558322663 no 1759 0.469584368083535 2522 7337946 YHR072W ERG7
SGTC_2120 5538279 151.968 µM -0.0763340259623723 0.475720431222305 no 1760 0.469576678000871 2563 2058197
SGTC_1957 st077035 62.4 µM -0.0773842308447873 0.47527895357248 no 1761 0.469158942562943 2556 705593
SGTC_660 4031-1742 102 µM -0.0777895852485078 0.475108561662953 no 1762 0.468997715556273 2543 6738706
SGTC_1174 0739-0097 51.1 µM -0.0782744251369299 0.474904763779047 no 1763 0.468804880408052 2581 728447
SGTC_1519 esterone 74 µM -0.0785931303080653 0.474770802633274 no 1764 0.468678125928833 2548 698 A steroid.
SGTC_3134 9127454 49.47 µM -0.0793359143953637 0.474458599757559 no 1765 0.468382720380397 2520 24262820
SGTC_1911 st060208 74.3 µM -0.079495825771601 0.474391388742668 no 1766 0.468319125829511 2634 688783
SGTC_1817 st052116 64.4 µM -0.0801889460722899 0.47410007758887 no 1767 0.468043490803303 2616 4361398
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.0803213265266286 0.474044441050055 no 1768 0.467990848448012 2553 688669
SGTC_2696 st077691 74.316 µM -0.0808949477455476 0.473803366767652 no 1769 0.467762748956872 2653 757133
SGTC_2094 5332512 191.667 µM -0.080937623269296 0.473785432019733 no 1770 0.46774577953034 2636 755774
SGTC_1864 st057645 30.4 µM -0.0811746643618838 0.473685814474362 no 1771 0.467651523959862 2564 688666
SGTC_956 1185-0240 191 µM -0.0816391165492959 0.473490631208339 no 1772 0.467466847295369 2587 1416193
SGTC_3222 9128301 49.47 µM -0.0823722454076455 0.473182551140624 no 1773 0.467175352992629 2580 4911358
SGTC_2496 diffractaic acid 79.83 µM -0.0834301699684814 0.472738011680464 no 1774 0.466754749981789 2566 94870 An apoptosis inducer which activates caspases.
SGTC_1691 st019933 84.6 µM -0.0846173611844947 0.472239194881918 no 1775 0.466282798170632 2546 6176082
SGTC_265 mycophenolic acid 32.932 µM -0.0847140958818053 0.472198552206588 no 1776 0.466244344679992 2741 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1969 st069479 40.1 µM -0.0864922504504396 0.471451520061449 no 1777 0.465537558115971 2632 3895485
SGTC_981 1488-1094 54.9 µM -0.0867561202053829 0.471340672507178 no 1778 0.465432683529879 2559 3449522
SGTC_1376 2910-0861 41.3 µM -0.0869111187724652 0.471275561069553 no 1779 0.465371080731403 2568 1112859
SGTC_2596 sinensetin 100 µM -0.0871957144183792 0.4711560107928 no 1780 0.46525797289124 2605 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_3348 9149464 3.537 µM -0.0894073042426688 0.470227076233274 no 1781 0.464379109387568 2542 1951442
SGTC_1090 efavirenz 20.7 µM -0.0894565523803244 0.470206392352398 no 1782 0.464359540636032 2603 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_912 3474-0017 2.18 µM -0.0896377016457415 0.470130311592363 no 1783 0.464287561702693 2674 3360550
SGTC_558 k064-0027 21.3 µM -0.0896852825690365 0.470110328292596 no 1784 0.464268655807566 2643 5088526
SGTC_2845 9003024 42.97 µM -0.0900373990582373 0.469962446801862 no 1785 0.464128747678329 2725 2990173
SGTC_2137 5261020 140 µM -0.0902903702312907 0.469856206806692 no 1786 0.464028236168878 2567 763655
SGTC_837 0091-0265 12.5 µM -0.0906716531745699 0.469696083930725 no 1787 0.463876747657917 2564 759367
SGTC_1648 st011736 69.8 µM -0.0907440457746215 0.469665682621769 no 1788 0.46384798575792 2671 2855514
SGTC_1763 st044482 94.5 µM -0.0912493070346248 0.469453502834465 no 1789 0.463647248495525 2676 88505
SGTC_2313 7726885 200 µM -0.0919667331166289 0.469152241311912 no 1790 0.463362235336395 2648 726423
SGTC_1514 1189-1591 158 µM -0.09225286863047 0.469032092218832 no 1791 0.463248566999918 2718 767698 YMR146C TIF34
SGTC_1722 st034304 3.6505 µM -0.0931071751453543 0.468673383374713 no 1792 0.462909208629276 2593 4036148 YLR033W RSC58
SGTC_2401 5128683 200 µM -0.093363474337761 0.468565772628092 no 1793 0.462807403495426 2595 708373
SGTC_2074 5212007 75.395 µM -0.0935277298813007 0.468496808882464 no 1794 0.462742160490724 2560 758611
SGTC_423 5-fluorouracil 457 µM -0.0935830617005833 0.468473577675276 no 1795 0.462720182680953 2555 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3011 9081274 71.4286 µM -0.0937293625962041 0.468412153383893 no 1796 0.462662072484157 2611 6625322
SGTC_1473 k844-0725 134 µM -0.0939497762973105 0.468319614322162 no 1797 0.462574526448879 2583 54682906
SGTC_532 1548-0774 215 µM -0.0944810737239187 0.468096560073861 no 1798 0.462363508082983 2761 5932993
SGTC_723 4182-0001 115 µM -0.094792599283523 0.4679657771571 no 1799 0.46223978265926 2600 744821 YLR208W SEC13
SGTC_1679 SEC14.276 6.7 µM -0.0964038887020071 0.467289390152657 no 1800 0.461599901886799 2715 1005053 YMR079W SEC14
SGTC_2482 5981709 142.65 µM -0.0969982145799162 0.46703992779845 no 1801 0.461363906161798 2642 877755
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0980199193640392 0.466611107726858 no 1802 0.460958238084049 2643 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2335 9018011 154.17 µM -0.098918740146819 0.466233895369286 no 1803 0.460601394697688 2683 6458208
SGTC_1267 0828-0272 9.49 µM -0.0996814901594995 0.465913812250675 no 1804 0.46029859802695 2663 745334
SGTC_1362 1611-0397 101 µM -0.102037790224724 0.464925146307801 no 1805 0.459363339675241 2603 27816
SGTC_705 1124-0212 310 µM -0.102168092044328 0.464870480002499 no 1806 0.459311627026423 2574 9554485
SGTC_737 1950-0117 57.9 µM -0.102215495927792 0.46485059253087 no 1807 0.459292814103179 2594 5393513
SGTC_924 2046-0044 21.3 µM -0.103588065769276 0.464274793096036 no 1808 0.458748129422703 2586 3623589
SGTC_2618 avocadyne 43.43 µM -0.103750621431258 0.464206605170831 no 1809 0.458683626645667 2625 3015189
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.104040093431418 0.464085181705644 no 1810 0.45856876562115 2626 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1349 flufenamic acid 69 µM -0.104618537038078 0.463842554704893 no 1811 0.458339252497879 2587 3371 A non-steroidal anti-inflammatory.
SGTC_1694 st024011 44.9 µM -0.1048502196164 0.463745379682497 no 1812 0.458247330068955 2604 2787533
SGTC_3175 9106517 49.47 µM -0.105567336517112 0.463444611841105 no 1813 0.457962820789182 2666 41468073
SGTC_2544 sphondin 68.51 µM -0.105884751451677 0.463311490688479 no 1814 0.457836896313957 2803 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2781 5567276 71.43 µM -0.106518309609336 0.463045794026355 no 1815 0.457585564541991 2751 2853274
SGTC_2545 solidagenone 89.61 µM -0.107070523205254 0.462814224451601 no 1816 0.457366515892025 2574 6708572 An anti ulcer agent
SGTC_2477 5967686 25.23 µM -0.10797723616286 0.46243402370635 no 1817 0.457006874764563 2610 776118
SGTC_2953 9074162 66.49 µM -0.109525286225495 0.461784978498409 no 1818 0.456392933450702 2639 16451992
SGTC_1152 3909-8331 15.9 µM -0.1102170562249 0.461494975449615 no 1819 0.456118617886043 2613 16001939
SGTC_283 0987-0079 11.7 µM -0.112812099695735 0.46040726791737 no 1820 0.45508976270705 2639 411556
SGTC_455 paf C-16 10 µM -0.113489089236323 0.460123557425068 no 1821 0.454821406362121 2604 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_270 tamoxifen 5.46 µM -0.11483322058581 0.459560323701235 no 1822 0.454288658501932 2641 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3067 9117431 49.47 µM -0.114946072613055 0.459513038794792 no 1823 0.454243933211728 2664 17150885
SGTC_548 1436-0017 110 µM -0.114984844072712 0.459496793717281 no 1824 0.454228567518091 2658 9677137
SGTC_664 1222-0054 14.9 µM -0.115336651926461 0.459349390809528 no 1825 0.454089144080058 2644 6813991
SGTC_2650 prasterone 100 µM -0.115614811512778 0.459232849521183 no 1826 0.453978911869945 2605 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_382 3229-0966 23.2 µM -0.116411438537898 0.458899103918933 no 1827 0.453663235193532 2729 5722370
SGTC_3350 9150499 3.57 µM -0.119192615319675 0.457734163027448 no 1828 0.452561378531922 2620 4910996 YPR165W RHO1
SGTC_2375 9072683 200 µM -0.119550559805973 0.457584258344526 no 1829 0.452419593141157 2608 16798029
SGTC_1619 st003326 88.7 µM -0.120370752066445 0.457240790269043 no 1830 0.452094729692374 2763 2849032
SGTC_512 prima-1 270 µM -0.121680590078896 0.456692341862972 no 1831 0.451575992934744 2771 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1134 3477-0009 42.5 µM -0.122398001900553 0.456391985895614 no 1832 0.451291910433241 2847 3973534
SGTC_2806 7952793 58.44 µM -0.12286719948327 0.456195562266164 no 1833 0.45110612990056 2744 2972490
SGTC_2470 5664817 21.68 µM -0.122952765158502 0.456159742431889 no 1834 0.451072251005799 2624 2859561
SGTC_3325 9138760 55.175 µM -0.122975248499355 0.456150330427783 no 1835 0.451063349005344 2657 43844959
SGTC_3077 9117319 49.47 µM -0.123038095259445 0.456124021569455 no 1836 0.451038465739333 2608 17154678
SGTC_971 1315-0384 26.7 µM -0.123228290682546 0.45604440329241 no 1837 0.450963161784088 2654 6769120
SGTC_914 3820-6779 408 µM -0.123479881617501 0.455939086767895 no 1838 0.450863552254013 2622 2893481
SGTC_2703 st077852 53.4 µM -0.124039229759807 0.455704953495125 no 1839 0.450642107018703 2753 6281836
SGTC_3 0833-0587 95.581 µM -0.124349717953274 0.455574995244162 no 1840 0.450519191754928 2609 5382644
SGTC_604 1000-0114 314 µM -0.125296267304699 0.455178835986676 no 1841 0.45014450357849 2701 1572745
SGTC_1841 st054148 70 µM -0.126069835725363 0.454855107507778 no 1842 0.449838322266425 2691 675442
SGTC_2290 7904846 200 µM -0.126151684268771 0.454820856690532 no 1843 0.449805928046405 2694 2962154
SGTC_3160 9100216 49.47 µM -0.12652385114939 0.454665121813935 no 1844 0.449658635134404 2592 17191039
SGTC_2734 clemastine 41.6 µM -0.127191029255245 0.454385955644295 no 1845 0.449394602666777 2618 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2697 mebhydrolin 72.4 µM -0.129485694537838 0.453425975709484 no 1846 0.448486671880672 2716 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1327 1436-0082 2.18 µM -0.130124053265926 0.453158964602861 no 1847 0.448234140077859 2684 15992205
SGTC_131 0141-0277 33.849 µM -0.131584521824883 0.452548163270043 no 1848 0.447656464428337 2776 1547771
SGTC_1825 st052143 62.6 µM -0.133603784062065 0.451703846872749 no 1849 0.446857945885273 2760 674173
SGTC_1689 st020265 53.493 µM -0.135027198580079 0.451108803971011 no 1850 0.44629518494933 2738 5758320 YPR016C TIF6
SGTC_2556 citropten 84.59 µM -0.135221848810097 0.451027441075457 no 1851 0.446218236446588 2638 2775 A potential DNA crosslinker.
SGTC_2663 amphotericin b 100 µM -0.136011770412836 0.450697278653524 no 1852 0.445905987996517 2655 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1229 0139-0193 12.2 µM -0.136248734320582 0.450598241823176 no 1853 0.445812324963806 2715 3090752
SGTC_858 0438-0351 2.77 µM -0.136474483562086 0.450503894917657 no 1854 0.445723097484785 2663 2799119
SGTC_3273 9137859 49.47 µM -0.137044546346357 0.450265662238248 no 1855 0.445497792184267 2645 2377234
SGTC_221 trifluoperazine 10.304 µM -0.137356920739671 0.450135126687809 no 1856 0.445374340249377 2653 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1771 st048882 4.1505 µM -0.137583267943082 0.450040543697804 no 1857 0.445284890002496 2656 4580403
SGTC_2887 9044784 58.44 µM -0.138859160828658 0.449507443608714 no 1858 0.444780721590462 2669 6465546
SGTC_772 k072-0172 35.3 µM -0.13886601434739 0.449504580281665 no 1859 0.444778013666538 2685 5861980
SGTC_469 w7 172 µM -0.139553815079395 0.449217237866908 no 1860 0.444506266823289 2642 45115570 A P450 inhibitor.
SGTC_3021 9087658 49.47 µM -0.139643561186789 0.449179746609175 no 1861 0.444470810478185 2666 25237042
SGTC_201 4262-0159 12.803 µM -0.139837802179778 0.44909860437513 no 1862 0.444394072452572 2746 1341029
SGTC_658 3253-0951 102 µM -0.14261645761885 0.447938083498807 no 1863 0.443296549525422 2695 1184878
SGTC_55 0767-0285 6.563 µM -0.142986758216384 0.44778345882068 no 1864 0.443150319570968 2720 3116166
SGTC_2184 6075246 200 µM -0.143148190958801 0.447716052592116 no 1865 0.443086572966786 2717 2267320
SGTC_3155 9099265 49.47 µM -0.143768969006433 0.447456860851927 no 1866 0.442841453704778 2764 25236499
SGTC_194 1486-1323 56.904 µM -0.144429192331042 0.447181224256976 no 1867 0.442580783161184 2685 5178754
SGTC_1655 st012546 55.1 µM -0.144683318760454 0.447075135821661 no 1868 0.4424804551324 2757 720985 YLR208W SEC13
SGTC_706 4262-0057 46.9 µM -0.145071435138886 0.446913118822774 no 1869 0.442327235565177 2661 883298
SGTC_2644 guaiazulene 100 µM -0.145084101684535 0.446907831393692 no 1870 0.442322235244707 2747 3515 A coloring agent.
SGTC_2896 9052656 71.43 µM -0.145574965464103 0.44670293612836 no 1871 0.442128466041835 2674 6469436
SGTC_712 r015-0009 80.6 µM -0.145591100346624 0.446696201382857 no 1872 0.442122097007888 2770 6813872 YLR060W FRS1
SGTC_2917 7979103 53.79 µM -0.145632976641289 0.446678722171007 no 1873 0.442105566957817 2801 2980565
SGTC_3262 9137218 49.47 µM -0.145691700249136 0.446654211046441 no 1874 0.442082386849004 2623 17650664
SGTC_287 k060-0039 29.6 µM -0.146074515712984 0.446494429583577 no 1875 0.441931282058093 2783 5861974
SGTC_2349 9023730 187.07 µM -0.147823255652368 0.445764642485926 no 1876 0.441241127805179 2777 4126287
SGTC_2793 7325131 81.82 µM -0.14823566925428 0.445592560027279 no 1877 0.441078391385803 2748 4176441
SGTC_817 1391-0715 46 µM -0.14848519098109 0.445488450316849 no 1878 0.440979936143854 2728 1353946
SGTC_1989 st071868 50.2 µM -0.148616191976794 0.445433793351572 no 1879 0.440928247777393 2793 16414057
SGTC_566 0958-0068 16.5 µM -0.148864486219905 0.445330201490745 no 1880 0.440830282399732 2806 6815365
SGTC_2866 9034245 58.44 µM -0.149610023610507 0.44501917523351 no 1881 0.440536149750621 2782 6462273
SGTC_902 1120-0002 2.07 µM -0.149649271575836 0.445002802547114 no 1882 0.44052066638046 2672 3280475
SGTC_1540 guanosine 70.6 µM -0.14990141945621 0.444897618742771 no 1883 0.440421195904171 2650 6802 Guanosine is a purine nucleoside
SGTC_2063 5246145 200 µM -0.149980013085629 0.444864834104501 no 1884 0.440390192066184 2765 711240
SGTC_2706 st078239 82.5 µM -0.150174418374351 0.444783741276231 no 1885 0.440313504086543 2668 15434492
SGTC_1881 5652484 16 µM -0.150259608419326 0.44474820643968 no 1886 0.440279899469318 2741 2255129
SGTC_1244 0416-0015 52.5 µM -0.150951124830507 0.444459774607414 no 1887 0.440007135362888 2692 96201
SGTC_1274 0865-0114 173 µM -0.151145380054994 0.44437875594304 no 1888 0.439930517782258 2734 870624
SGTC_2938 9059746 27.26 µM -0.151390940476603 0.444276342577837 no 1889 0.439833667774528 2785 6471769
SGTC_1505 k297-0037 20.6 µM -0.151600019964413 0.444189146873545 no 1890 0.439751208829879 2699 4089396
SGTC_2925 9010536 32.5 µM -0.15184373436743 0.44408751023622 no 1891 0.439655093506021 2769 2994177
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.152638874383697 0.443755937228393 no 1892 0.439341533435595 2709 2374 Ca(2+)-ATPase inhibitor.
SGTC_739 1486-1183 203 µM -0.153023903099168 0.443595394570733 no 1893 0.439189712668503 2703 4346692
SGTC_1500 4488-1866 171 µM -0.153799739542946 0.443271927768348 no 1894 0.438883819603995 2827 2900003
SGTC_1709 st033179 39.1045 µM -0.156161724089236 0.442287387329953 no 1895 0.437952773143025 2687 573381
SGTC_1266 0828-0227 32.9 µM -0.157648669757489 0.44166776967318 no 1896 0.437366825075023 2797 3913820
SGTC_2441 5730946 39.09 µM -0.157706006717407 0.441643879924828 no 1897 0.437344233527437 2807 1774275
SGTC_964 1287-0107 19.4 µM -0.158851624562636 0.441166596784215 no 1898 0.436892887317285 2812 51516812 YPR165W RHO1
SGTC_488 nitrendipine 139 µM -0.159332464898078 0.440966296246736 no 1899 0.43670347208714 2676 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2831 7999036 19.48 µM -0.159491310463468 0.44090013029635 no 1900 0.436640901967997 2977 2988270
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.159629052170689 0.440842756338144 no 1901 0.436586646054835 2692 6708561
SGTC_1906 st060206 94.7 µM -0.160171503537029 0.440616819561264 no 1902 0.43637298821856 2796 5133468
SGTC_2125 5246583 200 µM -0.160305587659195 0.440560975071769 no 1903 0.436320178742224 2723 835267
SGTC_1772 st048439 82.2 µM -0.161519985280038 0.440055246450136 no 1904 0.435841936019359 2749 2927068 YDL195W SEC31
SGTC_901 1112-0062 60.1 µM -0.162013527140133 0.439849741795617 no 1905 0.435647600743521 2698 1908457
SGTC_983 1491-0821 12.2 µM -0.162318557284302 0.439722739159963 no 1906 0.435527500932513 2838 46495113
SGTC_1301 naphtanilide LB 4.81 µM -0.162642519665079 0.439587860673238 no 1907 0.435399953425378 2795 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_87 0100-0052 35.5 µM -0.163009664801837 0.439435011956716 no 1908 0.435255412522694 2715 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1960 st011366 51.8 µM -0.164236963482389 0.438924132466063 no 1909 0.43477230175997 2680 3972846
SGTC_1610 st001799 48.1 µM -0.164336905238986 0.438882534841116 no 1910 0.434732965216337 2683 621897
SGTC_2095 5432005 200 µM -0.165002496418743 0.438605520605128 no 1911 0.434471008566482 2738 783734
SGTC_908 3448-7491 47.7 µM -0.165011687286497 0.438601695642622 no 1912 0.43446739151874 2726 1203031
SGTC_1430 4049-0248 69.1 µM -0.165220496481242 0.43851479708691 no 1913 0.434385216553684 2807 22774488
SGTC_2273 7815444 169.05 µM -0.16551242316642 0.438393313118529 no 1914 0.434270336207021 2889 2824616
SGTC_874 0599-0792 117 µM -0.165987945249523 0.438195439190224 no 1915 0.434083218434421 2727 765305
SGTC_1563 conessine 56.1 µM -0.167122077371882 0.437723567356808 no 1916 0.433636997536462 2809 441082 An anti-amoebic, histamine inhibitor.
SGTC_2805 7950783 58.44 µM -0.167252858089523 0.437669159856939 no 1917 0.433585547681106 2831 1178958 YDL195W SEC31
SGTC_3207 9114163 49.47 µM -0.168094267699462 0.437319144175601 no 1918 0.433254559450144 2938 849233
SGTC_2944 9067346 25.62 µM -0.168883261957924 0.436990977169018 no 1919 0.432944232551541 2860 6473075
SGTC_1932 st074806 40.9 µM -0.169197362534455 0.436860345119365 no 1920 0.43282070213775 2943 17251235
SGTC_515 4092-1064 102 µM -0.169414309894237 0.436770122375191 no 1921 0.432735384263841 2895 717353
SGTC_2122 5258151 111.688 µM -0.16970955091333 0.436647344626072 no 1922 0.432619281246701 2743 2173356
SGTC_296 1222-0039 74.9 µM -0.170747432732114 0.436215783756986 no 1923 0.432211182261402 2741 5984176
SGTC_617 3770-0098 35 µM -0.171182465288989 0.436034915743819 no 1924 0.432040147328105 2720 5962639
SGTC_2549 cedrol 20.94 µM -0.171674151609907 0.435830509611916 no 1925 0.431846854056299 2850 6708665 A sedative which affects the nervous system.
SGTC_2013 4024628 200 µM -0.171733719266183 0.435805747030838 no 1926 0.431823437739166 2845 5230760
SGTC_742 0kpi-0133 140 µM -0.171754437835553 0.435797134273976 no 1927 0.431815293231275 2872 2728852
SGTC_1903 st060211 78.3 µM -0.172326305889634 0.435559419444026 no 1928 0.431590502294834 2879 688960
SGTC_1831 st055328 12 µM -0.172384167333119 0.435535368822247 no 1929 0.431567759246067 2843 1103068
SGTC_1400 3771-8998 51.5 µM -0.172418034973802 0.435521291547866 no 1930 0.431554447319027 2730 670767
SGTC_2655 perillic acid 100 µM -0.17480389768473 0.434529801002805 no 1931 0.43061686279333 2707 5702197 An apoptosis inducer.
SGTC_3183 9108214 49.47 µM -0.175216925767316 0.434358200966092 no 1932 0.430454592613133 2726 4974831
SGTC_1556 plumbagin 1.48 µM -0.175572342493417 0.434210546515071 no 1933 0.430314966141083 2706 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2152 5568786 200 µM -0.17616110564148 0.433965970747861 no 1934 0.430083688042192 2693 5399883
SGTC_1386 3228-0095 33.8 µM -0.177067390133351 0.433589544130709 no 1935 0.429727728028732 2851 870181
SGTC_1144 3486-0183 12.5 µM -0.177233491800586 0.433520560076103 no 1936 0.429662494708792 2743 6744069
SGTC_3344 9148862 3.898 µM -0.177325916555681 0.433482175821349 no 1937 0.429626197448124 2873 4905352
SGTC_1208 2323-2347 50.3 µM -0.177910162932207 0.433239551228311 no 1938 0.429396764656312 2842 5412760
SGTC_2513 baicalein 25.65 µM -0.177999099433134 0.433202620071534 no 1939 0.429361841497568 2750 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_526 4469-0568 170 µM -0.179458255612172 0.4325967844867 no 1940 0.428788946185319 2697 2901964
SGTC_414 piperonyl butoxide 100 µM -0.180014791593972 0.432365754715964 no 1941 0.42857047794051 2721 5794 A potent inhibitor of cytochrome P450.
SGTC_2453 5731132 22.18 µM -0.182694861005339 0.431253526797638 no 1942 0.427518724110757 2848 1362040
SGTC_3303 9125618 40.5795 µM -0.184513185742001 0.430499232342782 no 1943 0.426805442009008 2831 22695467
SGTC_1878 temozolomide 1 mM -0.185327461065216 0.43016152906429 no 1944 0.426486100139293 2749 5394 DNA alkylating agent.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.186163276142705 0.429814945758807 no 1945 0.426158360943554 2716 364106
SGTC_2645 abamectin 100 µM -0.186685955652175 0.429598236297487 no 1946 0.425953434137707 2826 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_78 0336-0123 156.75 µM -0.187105967908029 0.429424109331875 no 1947 0.425788774539638 2689 6765896
SGTC_3137 9097352 49.47 µM -0.188428224835351 0.428876023263009 no 1948 0.425270487870634 3044 44120435
SGTC_1665 st014639 11.4 µM -0.188840402772845 0.428705200196278 no 1949 0.425108952335373 2771 981133 YIL048W NEO1
SGTC_379 3970-0972 5.9 µM -0.18944562767425 0.428454394936713 no 1950 0.424871783081222 2801 2898042 YBL034C STU1
SGTC_3199 9111318 49.47 µM -0.191023533092932 0.427800646883017 no 1951 0.424253577949232 2859 8548020
SGTC_162 k030-0015 37.8 µM -0.193706122608404 0.42668966864412 no 1952 0.423202998750755 2845 1809920 YMR134W ERG29
SGTC_1406 3909-7906 11.9 µM -0.194141696713009 0.426509332891201 no 1953 0.423032466717149 2776 X1406
SGTC_1501 4491-0275 38.4 µM -0.19569424038266 0.425866676259809 no 1954 0.422424746379632 2746 5104718
SGTC_1028 k015-0029 4.8 µM -0.197612930138872 0.425072730030918 no 1955 0.421673958758904 2739 4588309
SGTC_2226 7298446 200 µM -0.198682374613657 0.424630329788979 no 1956 0.421255606088823 2850 3283010
SGTC_1985 st071382 65.5 µM -0.198804172175244 0.424579951444058 no 1957 0.421207966107278 2759 6123237
SGTC_2389 9091542 195.52 µM -0.198829532432407 0.424569461998337 no 1958 0.421198046824021 2825 3626624 YOL127W RPL25
SGTC_50 0929-0078 56.389 µM -0.199583695895853 0.424257551251998 no 1959 0.420903090011907 2806 1377751
SGTC_2229 7354935 190 µM -0.200215445465266 0.423996305564524 no 1960 0.420656044001473 2823 318112
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.201115406073158 0.423624204992971 no 1961 0.420304167902805 2843 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_40 0327-0103 19.753 µM -0.201959884113184 0.423275106341211 no 1962 0.419974042873469 2808 409036
SGTC_1690 st023502 41.2 µM -0.20339408321863 0.422682361121825 no 1963 0.419413512033931 2851 24207482
SGTC_378 3970-0959 8.33 µM -0.203648947140163 0.42257704578684 no 1964 0.419313920145253 2895 6615653
SGTC_930 2810-3379 265 µM -0.204479458936309 0.422233898623938 no 1965 0.418989421139439 2978 1015764
SGTC_1273 0849-0096 14.1 µM -0.205930295870337 0.421634590042225 no 1966 0.418422679959517 2809 5286025
SGTC_3332 9141069 11.198 µM -0.206060212874841 0.421580933039215 no 1967 0.418371938655015 2749 17332883
SGTC_2670 beta-carotene 100 µM -0.206246291235383 0.421504083379212 no 1968 0.418299264940222 2858 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1109 tnp00067 928.257 nM -0.206690977982292 0.421320441547828 no 1969 0.418125601894114 2797 676295
SGTC_2504 purpurogallin 52.29 µM -0.206841442418382 0.421258308276478 no 1970 0.418066844788974 2765 5281571 An antioxidant.
SGTC_1637 st007924 17.4 µM -0.20733481468837 0.421054587298124 no 1971 0.417874193317093 2758 683336
SGTC_1954 st077032 68.9 µM -0.207578837210552 0.42095383446427 no 1972 0.417778914946642 2848 698907
SGTC_3305 9127027 53.8275 µM -0.207608169990287 0.420941723796633 no 1973 0.417767462314461 2814 41905295
SGTC_443 clozapine 122 µM -0.207807891889614 0.420859266313607 no 1974 0.417689485147881 2738 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2911 7942208 15.64 µM -0.207951612825138 0.420799931620412 no 1975 0.417633374368392 2865 1243384
SGTC_2766 oltipraz 83.91 µM -0.208508595558737 0.420570000226178 no 1976 0.41741593592169 2919 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1979 st071809 45.3 µM -0.209132200558495 0.42031259825041 no 1977 0.417172519017911 2917 4976333
SGTC_344 k064-0035 6.43 µM -0.209270090982237 0.420255686581838 no 1978 0.417118699389272 2793 5088750
SGTC_2492 derrusnin 100 µM -0.209417859536283 0.420194699752171 no 1979 0.417061025978913 2724 1715307 Part of coumarin class of compounds.
SGTC_1043 0916-0009 19.3 µM -0.209921356171407 0.419986911724944 no 1980 0.416864526886284 2948 3101130
SGTC_3320 9137005 35.139 µM -0.210385744403641 0.419795283113638 no 1981 0.416683308997875 2825 4908713
SGTC_1574 spiramycin 23.7 µM -0.210443359720433 0.419771509626205 no 1982 0.41666082704768 2751 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2118 5526350 200 µM -0.215892929871744 0.417524219254563 no 1983 0.414535604147914 2917 743594
SGTC_1990 st072050 59.8 µM -0.216757504569778 0.417167931935795 no 1984 0.414198665505175 2749 17233948
SGTC_2108 5365811 200 µM -0.216929222846833 0.417097175697211 no 1985 0.414131751642986 2897 780283
SGTC_790 1575-0012 79.1 µM -0.217415525148168 0.416896810195859 no 1986 0.41394226661998 2955 378741 YLR208W SEC13
SGTC_969 1313-0238 134 µM -0.217602179162911 0.416819911034737 no 1987 0.413869543225349 2797 5212874
SGTC_1438 4092-1045 4 µM -0.218087950751742 0.416619794034423 no 1988 0.41368029268399 2786 1351342
SGTC_1583 clindamycin 39.6 µM -0.219653005559858 0.415975205968393 no 1989 0.413070703445974 2780 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2176 5809774 33.9695 µM -0.220413578810258 0.415662035520303 no 1990 0.412774535539582 2926 2870539
SGTC_2950 9072895 21.46 µM -0.220628587185265 0.415573514276326 no 1991 0.412690820079239 2910 17332245
SGTC_1753 st043925 64 µM -0.221753768006699 0.415110335293994 no 1992 0.41225278557679 2900 670181
SGTC_1453 4237-0541 195 µM -0.221858972825725 0.415067033909933 no 1993 0.412211834768815 2912 739892
SGTC_852 0418-0143 439 µM -0.222623342755021 0.414752456938722 no 1994 0.41191433372007 2901 5369229
SGTC_755 1995-0008 37.3 µM -0.222927810900321 0.414627168074776 no 1995 0.411795845511149 2807 689533
SGTC_210 3551-0445 56.827 µM -0.22474499143553 0.413879577979228 no 1996 0.411088830858162 2929 2865180 YOR207C RET1
SGTC_3323 9138564 53.9225 µM -0.224801794128247 0.413856214303026 no 1997 0.411066735144026 2949 43912313 YNL103W MET4
SGTC_1499 4480-0877 67.3 µM -0.226131883732766 0.413309218721125 no 1998 0.410549423575591 2796 2861909
SGTC_2100 5377183 190 µM -0.227394385312941 0.412790174118038 no 1999 0.410058542908857 2904 2844202
SGTC_314 1671-0008 2.74 µM -0.227505307358306 0.412744578683389 no 2000 0.41001542137876 2800 3913060
SGTC_1952 st077036 64.1 µM -0.227783658674733 0.41263016523141 no 2001 0.409907215629291 2772 2937007
SGTC_946 3434-1334 87.4 µM -0.227864802507533 0.412596813288612 no 2002 0.409875673224637 2963 4047976
SGTC_611 3453-1652 23.7 µM -0.228638908014151 0.412278670249658 no 2003 0.409574790621409 2902 1560575
SGTC_1357 1503-1303 39.5 µM -0.229296525529722 0.412008446887814 no 2004 0.409319226888848 2830 292895
SGTC_1451 4152-0210 104 µM -0.229583549560529 0.411890518150063 no 2005 0.409207695502698 2978 659563
SGTC_1079 idarubicin 2.36 µM -0.231017051311505 0.411301658725686 no 2006 0.40865077763276 2835 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_420 mitomycin C 81.9 mM -0.231541391524374 0.411086318043439 no 2007 0.408447116570686 2824 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2378 9074213 121.43 µM -0.231650431213576 0.411041540020874 no 2008 0.408404767136088 2817 657714
SGTC_1526 st051518 75 µM -0.231805797199519 0.410977739735636 no 2009 0.408344427087457 2870 673993
SGTC_453 enantio-paf c16 10 µM -0.232742384018825 0.410593184863499 no 2010 0.407980727568496 2925 13871343 A lipid and platelet activating factor
SGTC_2483 5729050 27.16 µM -0.233325630915904 0.41035375186301 no 2011 0.407754278598862 2959 2865180
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.233880398058688 0.41012604129878 no 2012 0.407538915651171 2883 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2060 5238662 140 µM -0.235615192263345 0.40941417089969 no 2013 0.406865641801361 2927 790130
SGTC_2010 4012422 159 µM -0.235772453826723 0.409349653560437 no 2014 0.406804622141529 2907 952393
SGTC_2221 6807166 181.081 µM -0.237087768054929 0.408810135655109 no 2015 0.406294350776278 2884 674925
SGTC_2872 9044037 25.97 µM -0.237114768743823 0.408799062270995 no 2016 0.40628387762102 2797 6465195
SGTC_2082 5219693 150 µM -0.23812632308409 0.408384261317303 no 2017 0.405891559500635 2814 2834649
SGTC_1251 0490-5699 265 µM -0.239268296279323 0.407916103771366 no 2018 0.405448773700977 2971 3883818
SGTC_813 k007-0158 173 µM -0.240265181602656 0.407507533141258 no 2019 0.405062342779048 2904 6523916
SGTC_1934 st074720 32.6 µM -0.241775512174505 0.406888720210202 no 2020 0.404477057256399 2822 17250992
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.242402166120369 0.406632035559724 no 2021 0.404234278049633 3015 1273210
SGTC_535 2293-4129 48.2 µM -0.242417842606921 0.406625614804665 no 2022 0.404228205114234 2972 396118 YIL048W NEO1
SGTC_2303 7774051 200 µM -0.243262889907778 0.406279538617155 no 2023 0.403900875283184 3029 2953184
SGTC_3189 9110682 49.47 µM -0.244607674274478 0.405728953808222 no 2024 0.40338011066975 2939 17122418
SGTC_3034 9090421 49.47 µM -0.244820132312866 0.405641985760247 no 2025 0.403297852433596 2821 17173761
SGTC_2605 digitonin 300 nM -0.246284039489276 0.405042873552219 no 2026 0.402731182074242 2921 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1739 st037196 92.5 µM -0.24665003683978 0.404893121797677 no 2027 0.402589538401728 3016 612214
SGTC_3311 9131146 2.8755 µM -0.247842439222682 0.404405334239214 no 2028 0.402128158668492 2877 4900406 YPR165W RHO1
SGTC_3116 9124943 49.47 µM -0.248991390871686 0.403935462014014 no 2029 0.401683720416624 2870 41905195 YPL160W CDC60
SGTC_2992 9074591 71.4286 µM -0.251228458402448 0.403020994956615 no 2030 0.400818741672602 2961 17741321
SGTC_1139 k015-0024 46.9 µM -0.252019527552297 0.402697748836873 no 2031 0.400512985026863 2964 2766652
SGTC_536 3852-0578 10.6 µM -0.253408576201965 0.402130317790423 no 2032 0.399976250524829 3018 2869208
SGTC_1643 st009866 20.2 µM -0.255799774747312 0.401153988769206 no 2033 0.399052723924039 2947 3156273 YOR207C RET1
SGTC_636 0kpi-0074 126 µM -0.257213039849903 0.400577240714357 no 2034 0.398507159116313 2951 616434
SGTC_3095 9117207 49.47 µM -0.25725382172189 0.400560600999952 no 2035 0.398491418968774 2981 17015229
SGTC_3174 9107204 49.47 µM -0.257396462986166 0.400502402298183 no 2036 0.398436366528612 2983 3938802
SGTC_1168 k815-0004 80.5 µM -0.257556561874216 0.400437083386473 no 2037 0.398374578720627 2853 642433
SGTC_2404 5161160 200 µM -0.258247069413431 0.400155394422651 no 2038 0.398108116714778 2811 2831543
SGTC_2024 5144227 134 µM -0.258543313336462 0.40003455916549 no 2039 0.397993812824582 3020 3475211
SGTC_3142 9086498 49.47 µM -0.258907887271656 0.399885865842498 no 2040 0.397853156237861 2994 25236367
SGTC_1164 k060-0068 93.7 µM -0.259988918333277 0.399445047268436 no 2041 0.397436160818954 2877 5963676
SGTC_2172 5754775 163.918 µM -0.260189249168649 0.399363371211613 no 2042 0.397358898337399 2862 2263357
SGTC_2148 5546263 113.568 µM -0.260516289905772 0.399230044250613 no 2043 0.39723277574092 2846 792097
SGTC_1190 1486-1332 13 µM -0.261099409869161 0.398992348869878 no 2044 0.397007923378323 2886 4150046
SGTC_1067 clotrimazole 1.36 µM -0.261943022162157 0.398648536113334 no 2045 0.396682685194724 2876 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_159 3970-0959 50 µM -0.263356728043812 0.398072559119197 no 2046 0.396137819827704 2953 6615653
SGTC_632 0781-2353 4.65 µM -0.263952678306047 0.397829821437294 no 2047 0.395908191562598 2955 6811515 YHR007C ERG11
SGTC_1042 0350-0096 82 µM -0.264689659164537 0.397529695004779 no 2048 0.395624272125628 2848 3122515
SGTC_3020 9089140 49.47 µM -0.264733571808782 0.397511814030787 no 2049 0.395607356671501 2954 17217859
SGTC_3319 9138450 16.7555 µM -0.265473542136354 0.39721053482421 no 2050 0.395322344585856 2888 2029690
SGTC_1941 st076221 61.8 µM -0.265732651557464 0.397105052809604 no 2051 0.395222557436658 3030 2828568
SGTC_2584 androsterone 48.74 µM -0.267501029436603 0.396385357282836 no 2052 0.394541710833223 3009 2754130 A steroid.
SGTC_1147 3809-1045 12.3 µM -0.268092403808889 0.396144757998066 no 2053 0.394314096384078 2894 325925
SGTC_1942 st076330 65.2 µM -0.269019057006186 0.395767830884836 no 2054 0.393957508857507 3044 24208414
SGTC_2210 7115885 190.385 µM -0.269708933007172 0.39548727895098 no 2055 0.393692093804036 2895 2927039
SGTC_3272 9137413 49.47 µM -0.270861230687984 0.395018794782945 no 2056 0.393248882068519 2848 17614870
SGTC_1774 st048371 48.465 µM -0.272154450918274 0.394493197124787 no 2057 0.392751631611037 2878 4242727
SGTC_1248 0469-0687 58.6 µM -0.273621882148253 0.393897028275765 no 2058 0.392187608009897 2995 4017482
SGTC_188 3229-0966 278.469 µM -0.274653662597452 0.393477998694114 no 2059 0.391791167160921 2968 5722370
SGTC_2234 tolnaftate 200 µM -0.275286335045921 0.39322111695099 no 2060 0.39154813105156 2929 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3282 9108498 15.4605 µM -0.275463533590561 0.393149177984201 no 2061 0.391480069217704 2985 16459645
SGTC_1159 4092-0538 61.2 µM -0.276318260165543 0.392802227849785 no 2062 0.391151816048616 2906 717301
SGTC_2021 4019055 173 µM -0.276520797430019 0.392720026506081 no 2063 0.391074044047858 3032 44827708 YER133W GLC7
SGTC_882 0843-0131 351 µM -0.278738765579655 0.391820160522274 no 2064 0.390222655214494 2882 5425421
SGTC_1782 st039423 80.636 µM -0.27873938661514 0.391819908638794 no 2065 0.390222416897439 2947 2068169
SGTC_1245 0418-0076 17.2 µM -0.281920176429407 0.390530420997189 no 2066 0.389002359114876 3073 6790114
SGTC_1779 st039427 55 µM -0.282844998469374 0.390155724593135 no 2067 0.388647829174329 3129 1124498
SGTC_1688 st021091 57.6 µM -0.284726915116609 0.389393571766493 no 2068 0.387926684246772 3040 3656366
SGTC_245 methotrexate 289.6 µM -0.285176186778556 0.389211685103761 no 2069 0.387754581698781 2993 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2008 4012253 172 µM -0.285236447024483 0.38918729071856 no 2070 0.38773149947565 2892 603940
SGTC_3049 9092223 49.47 µM -0.286075871114538 0.388847522850773 no 2071 0.387410005833195 3005 8623917
SGTC_2537 larixol 68.93 µM -0.286991092189532 0.38847717202696 no 2072 0.387059570438992 2883 6708759
SGTC_1226 3909-7979 35.4 µM -0.288063108168792 0.388043501926542 no 2073 0.386649215802146 3023 6615510
SGTC_364 0083-0097 67.7 µM -0.288728280437101 0.387774485286718 no 2074 0.38639465964489 3051 5207356
SGTC_1022 4477-0945 21.3 µM -0.28906950889114 0.387636502633426 no 2075 0.386264093183104 2913 4648966
SGTC_1366 1683-0113 21.9 µM -0.289513048392769 0.387457169642658 no 2076 0.386094398031226 2909 708623
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.290146561296874 0.387201067782794 no 2077 0.385852058161149 2929 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2002 4023503 131 µM -0.290827975432907 0.386925656326521 no 2078 0.385591444190416 3034 4736863 YCR052W RSC6
SGTC_1897 st060201 15 µM -0.291564129626792 0.386628184205418 no 2079 0.385309952346087 2944 611878
SGTC_3148 9097893 49.47 µM -0.293805205293832 0.385722999929111 no 2080 0.384453378650947 2934 17174100
SGTC_3131 9127911 49.47 µM -0.294975200986033 0.38525067824657 no 2081 0.38400641200925 3166 45595681
SGTC_1944 st076371 56.9 µM -0.295429748186236 0.385067225567813 no 2082 0.38383280555724 2914 24208455
SGTC_942 3253-1115 227 µM -0.295988126001763 0.384841902649821 no 2083 0.383619574705622 3128 46497897
SGTC_1728 st035614 33.7865 µM -0.296651998106907 0.384574060091609 no 2084 0.383366104019779 3006 15945546
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.297691921426572 0.38415460854752 no 2085 0.382969154905361 3050 688662
SGTC_876 0720-0963 56.8 µM -0.300825129955992 0.382891655313916 no 2086 0.38177392228173 3121 765861
SGTC_810 3825-7150 143 µM -0.302170705882226 0.382349653238401 no 2087 0.381260967190803 3124 22330411 YGL099W LSG1
SGTC_673 1082-0474 110 µM -0.303063887836746 0.381990003999535 no 2088 0.380920587021145 2977 3098046
SGTC_2338 7999974 200 µM -0.303170577489811 0.381947051074258 no 2089 0.380879935119356 3001 315925
SGTC_2551 apiole 73.87 µM -0.303461284005464 0.381830020903276 no 2090 0.380769174043943 2903 10659 A possible DNA adduct former.
SGTC_704 1310-0270 142 µM -0.303799411601475 0.381693913940309 no 2091 0.380640357520163 3011 5718033
SGTC_2160 5660466 132.927 µM -0.305038234626107 0.381195373885822 no 2092 0.380168516063147 3001 2859134
SGTC_581 0958-0271 211 µM -0.305681054800152 0.38093676112104 no 2093 0.379923749681121 2950 4591145
SGTC_1719 st032227 49.2 µM -0.30599536545351 0.380810330259507 no 2094 0.379804087239021 2948 3125804
SGTC_1879 gemcitabine 100 µM -0.307427765944204 0.380234311227195 no 2095 0.37925889831849 2967 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2161 5662504 8.5105 µM -0.308734709892228 0.379708974321214 no 2096 0.37876166905995 2975 2859334
SGTC_1443 4112-3303 14 µM -0.309231282430016 0.379509431022694 no 2097 0.378572799657739 2958 704433
SGTC_729 4092-0585 94.1 µM -0.309976540066386 0.379210016040699 no 2098 0.378289398295457 2932 2169061
SGTC_2318 6029776 164 µM -0.311185316318536 0.378724531762521 no 2099 0.377829872572629 3144 818325
SGTC_207 4185-0010 4.486 µM -0.312087198993434 0.378362430602799 no 2100 0.377487127378417 3039 3761753
SGTC_85 0868-0259 160.055 µM -0.312908838050868 0.37803263978486 no 2101 0.377174961367877 3007 83173
SGTC_1440 4100-1550 40 µM -0.314455191508358 0.377412203081495 no 2102 0.376587671797439 2998 742806
SGTC_1803 st050068 52.4 µM -0.314677253998646 0.377323131840735 no 2103 0.376503358099622 3032 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_236 1509-0011 5.31 µM -0.315961103678572 0.376808296372131 no 2104 0.376016015815491 3081 3107280
SGTC_2419 paclitaxel 166.5 µM -0.317207287743175 0.37630877458277 no 2105 0.375543160220951 2866 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_963 1269-2853 151 µM -0.317233562393564 0.376298244849514 no 2106 0.375533192502877 2970 3668223
SGTC_2214 7179297 48.276 µM -0.317286701973183 0.376276949106408 no 2107 0.375513033388744 2973 769744
SGTC_1754 st042065 16.137 µM -0.317421303593177 0.376223009049355 no 2108 0.375461972228366 3020 1126236 YIL048W NEO1
SGTC_1594 piperine 70.1 µM -0.317464071492428 0.376205870809797 no 2109 0.375445748671063 2953 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_317 4495-0002 170 µM -0.319031234796144 0.375578035228183 no 2110 0.374851413725638 3001 15991618
SGTC_711 k292-0785 179 µM -0.319394825071749 0.375432421019851 no 2111 0.374713567245962 2936 4146315
SGTC_1838 st055369 84.5 µM -0.322032994101267 0.374376393849883 no 2112 0.373713849578257 2947 676036
SGTC_2789 5281112 71.43 µM -0.322591119741545 0.37415310332807 no 2113 0.373502459947271 3012 765948
SGTC_3093 9117344 49.47 µM -0.324374350528439 0.373439965595964 no 2114 0.372827318071515 3104 24824913
SGTC_1428 4049-0204 61.7 µM -0.324683549913862 0.373316356648783 no 2115 0.372710292991312 3081 X1428
SGTC_465 cgp-37157 41 µM -0.32519076816623 0.37311361373765 no 2116 0.372518347627596 3026 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1628 st004252 77.7 µM -0.325406616462761 0.373027346517381 no 2117 0.37243667428411 3116 692968
SGTC_1524 corynanthine 62.1 µM -0.326035135860833 0.372776184969166 no 2118 0.372198885861152 3144 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_602 3130-1533 38.1 µM -0.326414458015875 0.372624630858931 no 2119 0.372055400070608 3085 720941
SGTC_1622 st003707 19.4 µM -0.327396558448363 0.372232334801204 no 2120 0.371683984563271 3111 10140899
SGTC_2987 9018338 71.43 µM -0.327950881449519 0.37201097121146 no 2121 0.371474400697454 3085 5055682
SGTC_2276 7947513 42.08 µM -0.328871712977934 0.371643339467954 no 2122 0.3711263279361 3055 2105100
SGTC_1218 1348-1416 30.7 µM -0.329007055162115 0.371589315463402 no 2123 0.37107517769653 2958 6787668
SGTC_994 3910-0338 138 µM -0.329838790582823 0.371257370488878 no 2124 0.37076088770603 3168 3479481
SGTC_2105 5350118 200 µM -0.330591045905554 0.37095722841024 no 2125 0.370476705304502 3007 2133313
SGTC_667 1498-1044 59 µM -0.331795169496604 0.370476959010828 no 2126 0.370021966023156 3031 6739982
SGTC_71 0417-1750 47.813 µM -0.332084429534901 0.370361616548075 no 2127 0.369912753523935 3188 6811472
SGTC_1798 st045719 60.953 µM -0.332169501750365 0.370327696212956 no 2128 0.369880635807385 3059 3980186
SGTC_36 0335-0881 14.2 µM -0.332196846963342 0.370316793234041 no 2129 0.369870312232316 2994 23828853
SGTC_2312 7706453 155.7 µM -0.332599533475084 0.370156247673801 no 2130 0.369718297786424 3022 976098
SGTC_3066 9117245 49.47 µM -0.334085180279815 0.369564136641425 no 2131 0.369157641332269 3039 17176980
SGTC_1687 st020778 55.3625 µM -0.334749334154505 0.369299535134794 no 2132 0.368907091492691 3019 4259299
SGTC_2588 indole-3-carbinol 100 µM -0.335148679820117 0.369140464050855 no 2133 0.368756466476166 3128 3712 Induces cell cycle arrest.
SGTC_104 0074-0074 590.992 µM -0.335565144837066 0.368974597695575 no 2134 0.368599405863902 2909 3943124
SGTC_1329 1447-1697 50.6 µM -0.335770318814154 0.36889289161395 no 2135 0.368522037083899 3086 2840515
SGTC_2360 9040895 200 µM -0.335869939023962 0.368853222164894 no 2136 0.36848447335452 3038 4914414
SGTC_3109 9122853 49.47 µM -0.336273225662199 0.368692644947184 no 2137 0.368332419163556 3033 1234709
SGTC_854 0422-0053 192 µM -0.337020481335069 0.368395169693662 no 2138 0.36805073025891 3021 3596728
SGTC_674 0498-0004 451 µM -0.337485027725164 0.368210278013535 no 2139 0.367875648479986 3064 4231473
SGTC_1939 st074455 53.6 µM -0.339714954641863 0.367323182010429 no 2140 0.367035599333808 3215 1644229
SGTC_2291 7917025 104.35 µM -0.340144740160054 0.367152288536333 no 2141 0.366873765256089 2965 2964612
SGTC_698 k064-0052 127 µM -0.340684480804365 0.366937711432097 no 2142 0.366670561512559 3068 5088751
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.34118177842835 0.366740044591593 no 2143 0.366483369958441 3405 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_669 0108-0021 26.2 µM -0.341283096924194 0.366699776647035 no 2144 0.366445235791226 3296 17201
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.341506688631134 0.366610917723675 no 2145 0.366361085205566 2994 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1885 st057546 99.9 µM -0.342472635289343 0.366227117269425 no 2146 0.365997617088756 3171 702008
SGTC_215 1287-0124 461.5 µM -0.342526189928244 0.366205842267412 no 2147 0.365977468969165 3044 5560863
SGTC_2038 4100038 30.985 µM -0.34289588071683 0.366058990912358 no 2148 0.365838395411552 3103 3596803
SGTC_2796 7949634 45.45 µM -0.344251477167397 0.365520678702119 no 2149 0.365328586086065 2975 2971588
SGTC_431 k089-0097 107 µM -0.344841376436177 0.365286510201105 no 2150 0.36510681246751 3114 5499420
SGTC_968 1309-0633 340 µM -0.345558034875764 0.365002090496794 no 2151 0.364837444222964 3107 3761976
SGTC_2534 helenine 20.12 µM -0.345821393218457 0.364897590316335 no 2152 0.364738473270306 2968 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_776 4476-4378 112 µM -0.346000558596016 0.364826503508499 no 2153 0.364671147469027 3087 2892008
SGTC_63 0099-0242 26.702 µM -0.346474125190104 0.364638630558121 no 2154 0.364493213262616 3153 3898502 YLR359W ADE13
SGTC_3241 9133421 49.47 µM -0.347312237235051 0.364306215128185 no 2155 0.364178379173706 3068 17018221
SGTC_1559 coumarin 343 70.1 µM -0.347616611644055 0.364185518149086 no 2156 0.364064064578763 3180 108770 A hepatotoxic, DNA x-linker.
SGTC_1777 st045864 34.765 µM -0.348199764264496 0.363954311767664 no 2157 0.363845082402967 3092 4691462
SGTC_765 1319-0117 244 µM -0.350530945216095 0.363030548399488 no 2158 0.362970135277242 3022 3487746 YGL099W LSG1
SGTC_2708 st078559 56 µM -0.351269413745452 0.362738085642539 no 2159 0.362693119499014 3123 17250902
SGTC_2263 7948595 193.29 µM -0.352867092817605 0.362105615673338 no 2160 0.362094041010954 2988 2971371
SGTC_3100 9120536 49.47 µM -0.352886547489653 0.362097916507516 no 2161 0.362086748209999 3075 16421196
SGTC_2975 9084847 53.72 µM -0.352997290006657 0.362054091336781 no 2162 0.362045236095203 3103 27211724
SGTC_2189 6047310 154.431 µM -0.35318225180478 0.361980898709595 no 2163 0.361975906312444 3008 711535
SGTC_1309 pyrazolanthrone 13.4 µM -0.354558800393242 0.361436333021115 no 2164 0.361460072912191 3133 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1258 0671-0043 57.1 µM -0.354837364995202 0.361326166344949 no 2165 0.361355717124578 3083 4298767
SGTC_819 1013-0258 27.7 µM -0.354968434333753 0.361274335044954 no 2166 0.361306619536195 3047 5753198
SGTC_1993 st073995 70.8 µM -0.357575191075841 0.360244024543458 no 2167 0.360330623507544 3036 3098394
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.359881768587289 0.359333204094317 no 2168 0.359467775701839 3110 66535 A nucleotide analog.
SGTC_1613 st002381 52.1 µM -0.361596834784515 0.358656476834316 no 2169 0.358826665158785 3109 551167
SGTC_174 3553-0389 74.3 µM -0.361604858290392 0.358653311976713 no 2170 0.358823666817146 3174 738071
SGTC_1856 st057054 55.7 µM -0.363950143899784 0.35772863512985 no 2171 0.357947619610247 3259 1266018
SGTC_2890 9046729 58.44 µM -0.365297685008852 0.357197716514858 no 2172 0.357444603140966 3046 903329
SGTC_2847 9005661 71.43 µM -0.371934597285072 0.354586884873017 no 2173 0.354970772570055 3136 2991449
SGTC_1720 st037298 9.481 µM -0.372239514379489 0.354467099315508 no 2174 0.354857264153031 3162 597396
SGTC_160 3453-0671 289.699 µM -0.374248889328412 0.353678084208413 no 2175 0.354109576969328 3056 5322268
SGTC_1433 4060-0023 7.6 µM -0.37676871188136 0.352689521260042 no 2176 0.353172747215977 3189 3840627
SGTC_1331 1472-0049 76.2 µM -0.377310965902774 0.35247691686816 no 2177 0.352971261900625 3021 24051409
SGTC_1469 k284-2957 126 µM -0.377329627021865 0.352469601124674 no 2178 0.352964328722374 3107 23884841
SGTC_1167 k781-0610 148 µM -0.377854046951174 0.352264034403755 no 2179 0.352769510600598 3103 4525169
SGTC_2955 9076254 12.21 µM -0.378569404904243 0.351983691714894 no 2180 0.352503822665223 3163 16459619
SGTC_208 k072-0098 12.366 µM -0.381697240976533 0.350758865925576 no 2181 0.351342973401428 3086 5948901
SGTC_1738 st035555 74 µM -0.381944025464808 0.350662293653842 no 2182 0.351251441880377 3179 5331140
SGTC_2281 7943571 200 µM -0.382745795837059 0.350348609662117 no 2183 0.350954127566063 3309 1244024
SGTC_851 0394-0702 453 µM -0.383257632360249 0.350148412506209 no 2184 0.350764374877644 3215 762646
SGTC_3216 9129716 49.47 µM -0.384902296456991 0.34950540896969 no 2185 0.350154902208167 3089 8056934
SGTC_609 0986-0026 86.3 µM -0.385363778137556 0.349325063962871 no 2186 0.349983957512205 3087 2848610
SGTC_2775 cyproheptadine 69.59 µM -0.386093813068272 0.349039839004583 no 2187 0.349713595869742 3188 2913 A selective serotonin reuptake inhibitor.
SGTC_355 1311-2252 105 µM -0.387035316036236 0.348672119297577 no 2188 0.349365031522211 3100 5338538
SGTC_2910 7948405 25.97 µM -0.388442193175176 0.348122904879439 no 2189 0.348844412538051 3243 2971328
SGTC_2029 5175081 200 µM -0.390785512071683 0.347208831094295 no 2190 0.347977892416123 3075 1380876
SGTC_271 rotenone 740 µM -0.391405851865457 0.346966999531833 no 2191 0.347748633748421 3212 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_736 0958-0254 92.6 µM -0.391522299311222 0.346921610923335 no 2192 0.34770560452639 3200 6812352
SGTC_116 0155-0182 31.788 µM -0.391568282328285 0.346903688377169 no 2193 0.347688613595182 3099 771486
SGTC_1463 k081-0032 34.1 µM -0.393352627218263 0.346208479020441 no 2194 0.347029526710705 3155 977755
SGTC_1640 st009078 66.4 µM -0.396421840742955 0.34501387688253 no 2195 0.345896928245472 3203 690618
SGTC_1741 st038134 10.228 µM -0.397951874525564 0.34441893127982 no 2196 0.345332830367479 3328 1272587
SGTC_2587 piperic acid 92.2 µM -0.398827774269663 0.34407851532798 no 2197 0.345010055249743 3136 5370536
SGTC_2807 7945238 51.95 µM -0.39937702473852 0.343865115114692 no 2198 0.344807710149153 3173 17148797
SGTC_816 0325-0417 81.3 µM -0.399410659662229 0.343852048557465 no 2199 0.344795320409665 3177 68101
SGTC_1055 3448-0672 86 µM -0.4018275216953 0.342913630573882 no 2200 0.343905483025376 3259 748378
SGTC_758 0868-0029 16 µM -0.401986765853138 0.342851833270284 no 2201 0.343846882984267 3210 762687
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.402757400820008 0.342552835178787 no 2202 0.343563351093404 3288 688751
SGTC_387 norethindrone acetate 66.7 µM -0.402799543118167 0.342536487262286 no 2203 0.343547848642084 3135 541197
SGTC_196 k015-0023 18.111 µM -0.403179953958501 0.342388930953085 no 2204 0.343407922752757 3107 5211998
SGTC_1368 1852-0141 284 µM -0.403523870296854 0.342255551079261 no 2205 0.343281439045246 3214 2838987
SGTC_3292 9120825 59.784 µM -0.403911166150169 0.342105371034462 no 2206 0.343139022465341 3284 24824900
SGTC_463 ikarugamyin 104 µM -0.404131876478298 0.342019798310516 no 2207 0.343057872742419 3183 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2328 6201408 200 µM -0.404779292482666 0.341768832181001 no 2208 0.342819875674374 3216 2890418
SGTC_101 0490-5701 117.494 µM -0.406272143979864 0.341190405731837 no 2209 0.3422713252748 3201 4661669
SGTC_2557 derrustone 83.84 µM -0.406924004123607 0.340937950191515 no 2210 0.34203190260316 3229 629853 An antioxidant.
SGTC_90 0870-0863 4.608 µM -0.407088113935663 0.340874404167659 no 2211 0.341971636471057 3088 1738164
SGTC_1356 1502-0781 85.8 µM -0.407285791141156 0.340797866290166 no 2212 0.341899048713179 3112 567702
SGTC_136 0097-0015 404.482 µM -0.40757636153344 0.340685373353299 no 2213 0.341792360862871 3220 4861337
SGTC_634 1611-4317 11.2 µM -0.407941421306174 0.340544062291813 no 2214 0.341658340881105 3254 2843522
SGTC_2791 5663188 71.43 µM -0.409746536156998 0.339845649290815 no 2215 0.340995944491714 3278 54690634
SGTC_1871 st057448 67.3 µM -0.411075686165006 0.339331741825364 no 2216 0.340508518878416 3325 691747
SGTC_871 0574-0004 149 µM -0.411566159386085 0.339142178843514 no 2217 0.340328719855081 3099 9551173
SGTC_1708 st033234 31.827 µM -0.411834145799308 0.339038621977994 no 2218 0.34023049598728 3248 674664
SGTC_1119 parthenolide 318.541 nM -0.412934304773632 0.338613619668311 no 2219 0.339827373271696 3310 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2794 7785382 27.27 µM -0.413091726158526 0.338552823016482 no 2220 0.339769705539642 3250 2205081
SGTC_447 ml7 120 µM -0.414829118409745 0.337882116227779 no 2221 0.339133500876609 3220 4216 Selective myosin light chain kinase inhibitor.
SGTC_1154 4088-0362 150 µM -0.414931520285084 0.337842600811457 no 2222 0.339096017271022 3108 6618304
SGTC_3144 9087057 49.47 µM -0.414944004427086 0.337837783482162 no 2223 0.339091447633008 3252 17249618
SGTC_2353 9059630 146.67 µM -0.415342940380335 0.337683857710016 no 2224 0.33894543541608 3224 4779114
SGTC_1666 st014829 29 µM -0.417321649491519 0.336920792666341 no 2225 0.338221577598131 3125 3858230
SGTC_1094 duloxetine 25.4 µM -0.417334008964197 0.336916028490954 no 2226 0.338217058090775 3118 60834 A selective serotonin reuptake inhibitor.
SGTC_1204 4049-0315 18.3 µM -0.41820159388841 0.336581668092388 no 2227 0.337899865263992 3337 588402
SGTC_2471 5466956 24.79 µM -0.41869011919868 0.336393451106856 no 2228 0.337721308907591 3114 724419
SGTC_2679 rapamycin 1 nM -0.419307808195847 0.336155529163017 no 2229 0.337495595411674 3211 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3206 9114350 49.47 µM -0.419927736397642 0.335916810693496 no 2230 0.337269122445318 3227 17087243
SGTC_315 k915-0449 187 µM -0.420105464375993 0.335848384403924 no 2231 0.337204205501638 3199 20970215 YNL149C PGA2
SGTC_2920 7982904 15.77 µM -0.420821691433939 0.335572688050629 no 2232 0.336942645456372 3202 6456808
SGTC_1219 1469-0211 33.1 µM -0.422019504495448 0.335111813237927 no 2233 0.336505390485734 3245 6822282
SGTC_42 0133-0086 60.653 µM -0.423317401983917 0.334612709678837 no 2234 0.336031849713992 3080 162923 Model of phenazepam hydroxylation.
SGTC_1554 st069299 38.7 µM -0.424149148829155 0.334293016812869 no 2235 0.335728521746599 3231 24207999
SGTC_1200 1643-0193 18.4 µM -0.427282330967335 0.333089817387728 no 2236 0.334586850343241 3261 5403974
SGTC_2493 resveratrol 26.09 µM -0.427472665406244 0.333016780640717 no 2237 0.334517545247702 3110 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1062 mesoridazine 14.2 µM -0.428772919785693 0.33251800554274 no 2238 0.334044244012205 3188 4078 A neuroleptic.
SGTC_253 dyclonine 31.25 µM -0.429757741937727 0.332140426836807 no 2239 0.333685937736189 3228 3180 An oral anasthetic.
SGTC_2986 9022445 71.43 µM -0.429831557443473 0.332112132987898 no 2240 0.333659087662628 3292 6459286
SGTC_1080 nisoldipine 24.4 µM -0.429938232998792 0.332071245410318 no 2241 0.333620286392179 3095 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1627 st003713 25.6 µM -0.430794261393899 0.331743211486879 no 2242 0.333308986280562 3228 16195070 YER133W GLC7
SGTC_2265 7929201 200 µM -0.432735341278163 0.330999859058163 no 2243 0.332603525868933 3084 1265108
SGTC_2139 5578692 56.4705 µM -0.434476899959839 0.330333481337409 no 2244 0.331971082921054 3236 650991 YMR113W FOL3
SGTC_2721 ifenprodil 61.44 µM -0.434548651251258 0.330306038448634 no 2245 0.331945036857545 3302 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1785 bathophenanthroline 24 µM -0.437332382751087 0.329242043816509 no 2246 0.330935156938361 3160 72812 An iron chelator.
SGTC_2420 aureobasidin a 50 nM -0.438178841355622 0.328918784896057 no 2247 0.330628322671889 3384 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_301 4119-0100 24.5 µM -0.438436240314422 0.328820510688086 no 2248 0.330535040224015 3204 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.439082702995633 0.328573745228078 no 2249 0.330300805902585 3288 5024745
SGTC_1270 0831-1170 17.3 µM -0.439317757220302 0.328484039679696 no 2250 0.330215654636602 3242 6764716
SGTC_2269 7935389 174.42 µM -0.44010060771323 0.328185345747824 no 2251 0.329932120904652 3221 97605
SGTC_303 1348-1668 34.2 µM -0.440230842150512 0.328135665892614 no 2252 0.329884961911606 3205 5380509
SGTC_4 0960-0234 25.671 µM -0.440894082996003 0.327882710025035 no 2253 0.329644838741438 3265 6821112
SGTC_1898 st060199 18.6 µM -0.441021649538566 0.327834066000525 no 2254 0.329598661933597 3164 688866
SGTC_2617 dihydrotanshinone i 20.83 µM -0.443252830233239 0.326983739009952 no 2255 0.328791435016848 3175 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_3271 9137798 49.47 µM -0.443429201900253 0.326916560089836 no 2256 0.328727658863384 3260 6498326
SGTC_3209 9113616 49.47 µM -0.444282813634729 0.326591503753472 no 2257 0.328419062606183 3378 16649353
SGTC_1105 epirubicin 18.1 µM -0.444505126513921 0.32650686834314 no 2258 0.328338711631691 3159 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1750 st081859 2.357 µM -0.444692512970214 0.326435536498493 no 2259 0.328270990348477 3263 5291695
SGTC_811 0416-0114 265 µM -0.445354440961402 0.326183613161332 no 2260 0.328031815401467 3301 6612453
SGTC_1353 1498-1206 8.11 µM -0.446151626038058 0.325880317555966 no 2261 0.327743861492043 3278 6756808
SGTC_1052 3253-3998 198 µM -0.448698853388865 0.324911976826947 no 2262 0.32682445595005 3149 5450317
SGTC_176 1486-1328 72.834 µM -0.448853907320341 0.324853070422173 no 2263 0.326768524079788 3254 22310231
SGTC_2977 9011197 71.43 µM -0.44910323862563 0.324758356365199 no 2264 0.326678592141711 3352 2704722
SGTC_2907 7721985 69.9 µM -0.44941078807982 0.324641542451893 no 2265 0.326567675223933 3252 3267881
SGTC_68 0986-0284 82.829 µM -0.450696410282978 0.32415342226588 no 2266 0.326104184961624 3303 423278 YIL048W NEO1
SGTC_612 0302-0167 22.4 µM -0.450988871898625 0.324042423694044 no 2267 0.325998784675586 3242 235821
SGTC_2239 6685329 187.64 µM -0.451388596899941 0.323890740523584 no 2268 0.325854750206665 3304 805680
SGTC_58 0957-0393 9 µM -0.4518942292795 0.323698910695556 no 2269 0.325672590946929 3319 6997992
SGTC_2532 xanthone 78.9 µM -0.451967662055375 0.3236710552244 no 2270 0.325646139494989 3276 7020 An insecticide.
SGTC_1557 sumaresinolic acid 42.3 µM -0.45201849567457 0.323651772936508 no 2271 0.325627829070792 3179 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_313 3474-0040 5.03 µM -0.452110422604745 0.323616904271872 no 2272 0.325594717779425 3161 1043375 YIL048W NEO1
SGTC_2934 9036370 36.88 µM -0.45246136048677 0.323483804797117 no 2273 0.325468325622216 3261 6462800
SGTC_1997 st073024 93.8 µM -0.452576313854498 0.323440211583576 no 2274 0.325426928914022 3300 686268
SGTC_59 0330-0160 1.33 µM -0.453971697361713 0.322911240401685 no 2275 0.324924598894904 3294 4293482
SGTC_552 k242-0005 476 µM -0.45632209617704 0.322021045551265 no 2276 0.324079188455219 3316 4088318
SGTC_1476 4112-3294 3.34 µM -0.45683026906857 0.321828713074472 no 2277 0.323896523746352 3321 704369
SGTC_66 0109-0187 42.4 µM -0.457533318538415 0.321562702714056 no 2278 0.32364387981457 3315 759417
SGTC_1530 rhein 70.4 µM -0.458253646670309 0.321290249550879 no 2279 0.323385110994647 3260 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2104 5389443 200 µM -0.459506401067912 0.32081664331082 no 2280 0.322935278220265 3370 2244536
SGTC_713 1488-1073 324 µM -0.461988725546078 0.319879057193041 no 2281 0.322044702797923 3290 3312542
SGTC_3279 9140807 49.47 µM -0.46209139153353 0.319840304461481 no 2282 0.322007891609317 3267 45595718
SGTC_1188 1403-0014 4.57 µM -0.46258769617713 0.319652994976108 no 2283 0.321829964766428 3233 9614867
SGTC_1051 3253-3903 78 µM -0.462969823438632 0.31950880831569 no 2284 0.321692998718445 3152 5509239
SGTC_1363 1636-0063 10.4 µM -0.46373706659441 0.319219389704107 no 2285 0.321418068582844 3240 6072185
SGTC_2768 sulfasalazine 50.2 µM -0.463757802887423 0.319211569110493 no 2286 0.321410639398486 3379 5384001 An antioxidant and salicylic acid derivative.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.465219757058407 0.318660403041143 no 2287 0.320887045816431 3279 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2072 5231554 129 µM -0.465323132304968 0.318621445076443 no 2288 0.320850035812735 3359 789545
SGTC_1943 st076331 65.2 µM -0.46552598242732 0.318545004866803 no 2289 0.320777417375284 3332 24208415
SGTC_3105 9121040 49.47 µM -0.466028370370988 0.318355722779796 no 2290 0.320597596739373 3246 41448907
SGTC_598 3937-0236 20.2 µM -0.466405566572822 0.318213639690391 no 2291 0.320462613878666 3289 1379313
SGTC_2216 7189485 200 µM -0.466636619928301 0.318126619214268 no 2292 0.320379941201726 3307 731273
SGTC_1865 st057639 52.2 µM -0.467463907165337 0.317815124482178 no 2293 0.320084004546447 3256 688818
SGTC_1431 4049-0260 9.09 µM -0.467643993421268 0.31774733449062 no 2294 0.320019599367182 3266 3854841
SGTC_1597 7-benzyloxygramine 47.5 µM -0.467745123756476 0.317709268608247 no 2295 0.319983433980264 3291 260807
SGTC_2673 kobusone 100 µM -0.467820917069056 0.317680740950609 no 2296 0.319956330529513 3287 6710676 An epoxy ketone and protein crosslinker.
SGTC_2289 7946404 165.07 µM -0.468044914644711 0.317596437383584 no 2297 0.319876235316703 3202 1246120 YPR165W RHO1
SGTC_94 0334-0113 514.748 µM -0.468566311790792 0.317400241362276 no 2298 0.319689830934401 3257 6795178
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.469433775798398 0.31707393785233 no 2299 0.319379805313241 3334 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3326 9140064 16.379 µM -0.470058786122804 0.316838923342797 no 2300 0.319156509180836 3193 1868434
SGTC_3151 9099821 49.47 µM -0.471431680366027 0.316322951279698 no 2301 0.318666248503065 3307 17174189
SGTC_1189 1431-2119 7.28 µM -0.472926597883349 0.31576152588553 no 2302 0.318132774075279 3334 3107275
SGTC_1976 st070609 63.5 µM -0.474254849364229 0.315263049279577 no 2303 0.317659092173432 3250 682556
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.474602246894799 0.315132730632865 no 2304 0.317535252226079 3284 16486 A toxic proline analog.
SGTC_990 3985-0011 41.3 µM -0.474880313899994 0.31502843640367 no 2305 0.317436141870396 3256 5399565 YGL099W LSG1
SGTC_1225 1216-0074 20.6 µM -0.475021691126403 0.314975415885482 no 2306 0.317385756345907 3238 4241466
SGTC_1996 st072960 66.8 µM -0.47577564275509 0.31469272678466 no 2307 0.317117112176075 3361 1719405
SGTC_2870 9038528 12.99 µM -0.477733491344348 0.313959151949823 no 2308 0.316419951872154 3341 6463316
SGTC_172 1112-0046 2.638 µM -0.478510197825368 0.31366833569814 no 2309 0.316143558885419 3212 2802135 YIL048W NEO1
SGTC_2408 sulbentine 18.36 µM -0.479536298004364 0.313284318360544 no 2310 0.315778576001802 3200 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1816 st051957 91.6 µM -0.479939545692337 0.313133458538651 no 2311 0.315635190300925 3288 674121
SGTC_2750 bromebric acid 70.15 µM -0.480165684426688 0.313048870996481 no 2312 0.315554792655637 3362 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1117 retinoic acid 1.10837 µM -0.482847972754826 0.312046308365835 no 2313 0.314601842703178 3385 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_108 0509-0257 621.132 µM -0.484375385498264 0.311476026055616 no 2314 0.314059741974809 3279 536624
SGTC_1819 st053448 58.6 µM -0.484788186146568 0.311321978313138 no 2315 0.313913301871686 3224 2857616
SGTC_2478 5763493 32.33 µM -0.484807218919876 0.311314876514749 no 2316 0.313906550744612 3249 1365576 YLR208W SEC13
SGTC_3244 9134489 49.47 µM -0.485638028740141 0.311004940563005 no 2317 0.313611914401804 3327 16584271
SGTC_891 0929-0073 133 µM -0.486651546083891 0.310627026501695 no 2318 0.313252644063921 3363 5603632
SGTC_1676 st018489 23.4 µM -0.488144673647876 0.310070642317392 no 2319 0.312723684932547 3264 3696235
SGTC_838 0109-0203 71.4 µM -0.488542431312535 0.309922499116047 no 2320 0.312582839271801 3308 759422
SGTC_3301 9125354 19.7965 µM -0.488852049807467 0.309807204341485 no 2321 0.31247322255972 3329 41905162
SGTC_2253 7938677 135.83 µM -0.489317826575066 0.309633795073216 no 2322 0.312308351139058 3387 2301972
SGTC_780 0109-0199 192 µM -0.491191638820472 0.308936600807856 no 2323 0.311645456028917 3408 610414
SGTC_2331 7980721 200 µM -0.491314855436912 0.308890779351156 no 2324 0.311601887263435 3268 2981221
SGTC_1411 3909-8223 150 µM -0.491355891539775 0.308875519618171 no 2325 0.311587377692749 3358 X1411
SGTC_1145 3546-0597 10.2 µM -0.492722940273782 0.308367355972225 no 2326 0.31110418307838 3303 875334
SGTC_2867 9039098 71.43 µM -0.493285616213909 0.308158302851661 no 2327 0.310905395121115 3283 6463460
SGTC_2745 rifampicin 24.3 µM -0.493700066333443 0.308004360418035 no 2328 0.310759009190048 3292 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3013 9080133 71.4286 µM -0.493896462950161 0.307931423087897 no 2329 0.310689651344384 3452 17050193
SGTC_2927 9011802 47.9 µM -0.49431732064045 0.307775151465104 no 2330 0.310541047292394 3352 43912568
SGTC_2988 9073640 71.4286 µM -0.494575861788043 0.307679168022288 no 2331 0.310449772230239 3434 9102229
SGTC_1808 st050063 61.5 µM -0.494978449819376 0.307529733357491 no 2332 0.310307666262771 3382 4011993
SGTC_2468 5987765 72.9 µM -0.495021053101634 0.307513921523549 no 2333 0.310292629765632 3303 26772094
SGTC_2862 9027634 71.43 µM -0.49625272475362 0.307056952137315 no 2334 0.309858058022064 3213 5012562
SGTC_2438 5259590 200 µM -0.496919006085765 0.306809876168147 no 2335 0.309623084063361 3337 1201127
SGTC_1141 3253-0389 52.6 µM -0.497503381193973 0.306593245561036 no 2336 0.30941705957119 3345 5402031
SGTC_3285 9112818 20.8695 µM -0.497974674088461 0.30641858426922 no 2337 0.309250946427044 3331 17017947 YPR165W RHO1
SGTC_1641 st009299 47.1 µM -0.498832653392172 0.306100729781248 no 2338 0.308948640860564 3349 4046054
SGTC_371 0195-0006 7.36 µM -0.499012683146438 0.306034052904439 no 2339 0.308885224512124 3265 3928593
SGTC_682 0kpi-0099 17 µM -0.500024729825456 0.305659345008874 no 2340 0.308528832265735 3362 1714895 YML126C ERG13
SGTC_2729 fluphenazine 10.66 µM -0.500266428996165 0.305569886537734 no 2341 0.308443744563012 3250 3372 An atypical antipsychotic.
SGTC_862 0452-0056 10.2 µM -0.501098195196351 0.305262119283345 no 2342 0.308151008484163 3354 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1053 3366-3204 134 µM -0.502507020548863 0.304741144633792 no 2343 0.307655457605912 3290 3632071 YPR165W RHO1
SGTC_232 clozapine 119 µM -0.503160216727766 0.304499731040055 no 2344 0.307425816394452 3329 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3088 9117578 49.47 µM -0.503527147198378 0.304364155211767 no 2345 0.307296849413723 3404 678341
SGTC_299 1273-0059 1.44 µM -0.503895050960206 0.304228246753554 no 2346 0.307167564265776 3347 2848077
SGTC_3211 9128781 49.47 µM -0.503927784437163 0.304216155888993 no 2347 0.307156062547694 3302 17194361
SGTC_1474 0330-0125 5.35 µM -0.504851552957534 0.303875028982557 no 2348 0.306831551853174 3399 X1474
SGTC_1623 st003709 20.3 µM -0.505338589437615 0.303695246096222 no 2349 0.306660521683463 3283 16192618
SGTC_744 1594-0068 283 µM -0.505371387490798 0.30368314084768 no 2350 0.306649005667095 3302 668392
SGTC_906 1165-0455 526 µM -0.505486070438384 0.303640814858332 no 2351 0.306608739817314 3332 3252859
SGTC_1238 0333-0287 48.8 µM -0.505805592773176 0.30352290277114 no 2352 0.306496565979992 3305 7226
SGTC_996 3970-0799 1.8 µM -0.506407384329099 0.303300881515859 no 2353 0.306285345883865 3360 6615648 YGL040C HEM2
SGTC_715 0868-0130 184 µM -0.506462884520392 0.303280409275057 no 2354 0.306265869363398 3426 2876258
SGTC_3024 9090631 49.47 µM -0.508612819905547 0.302487842995454 no 2355 0.305511820587562 3380 25236383
SGTC_2085 5307070 144.047 µM -0.508918956050365 0.302375062526698 no 2356 0.305404516148406 3253 2840351
SGTC_1936 st074407 74.3 µM -0.509880378887324 0.30202099731439 no 2357 0.305067634479886 3280 809813
SGTC_1762 st045503 25.4615 µM -0.510558930419118 0.301771217852496 no 2358 0.304829970023785 3355 4645554
SGTC_2428 5615643 7.78 µM -0.511275912607861 0.301507392749946 no 2359 0.304578934578837 3369 2253075
SGTC_2191 5911152 200 µM -0.515264199306394 0.30004173697227 no 2360 0.30318420625931 3335 2875902
SGTC_2820 7989630 71.43 µM -0.516043331251433 0.299755790471056 no 2361 0.302912072841037 3330 2984098
SGTC_1588 farnesol 29.9 µM -0.516941644619446 0.299426256875056 no 2362 0.302598447790234 3365 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_785 1270-0111 65.3 µM -0.51810084574236 0.299001263203494 no 2363 0.302193955099725 3343 6741994
SGTC_2133 5320837 200 µM -0.518243542759636 0.298948965659027 no 2364 0.302144179053097 3420 2841355
SGTC_1715 st032160 10.2275 µM -0.519485343540592 0.298494029121398 no 2365 0.301711165463405 3362 5289825
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.520359240209105 0.298174064038099 no 2366 0.301406606719064 3274 4000243
SGTC_1633 st005664 67.9 µM -0.520385492442986 0.298164454566034 no 2367 0.301397459784045 3298 2063822
SGTC_2714 st079313 56.9 µM -0.520989850673698 0.297943271892133 no 2368 0.301186920817678 3348 2939799
SGTC_761 k216-0224 480 µM -0.522412878121429 0.297422768771372 no 2369 0.300691445700395 3477 1340404
SGTC_1790 st045711 43.5 µM -0.522752229501949 0.297298705006095 no 2370 0.30057334338932 3462 585119
SGTC_3196 9111891 49.47 µM -0.523157916546569 0.297150420567433 no 2371 0.300432182190146 3393 18891510
SGTC_121 0557-0495 61.343 µM -0.523658037238672 0.296967665824186 no 2372 0.300258203476286 3372 3104427
SGTC_10 0279-0212 42.575 µM -0.524618166118087 0.296616958492516 no 2373 0.299924327836069 3375 39851 YBR002C RER2
SGTC_3015 9080845 49.47 µM -0.524744645062889 0.296570773534182 no 2374 0.29988035852004 3433 5296973
SGTC_1418 3966-3099 2.4 µM -0.526526001777991 0.29592064488553 no 2375 0.2992613954087 3415 740335
SGTC_492 tmb-8 126 µM -0.527646258418504 0.295512128547003 no 2376 0.298872440035139 3335 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_879 0831-1030 162 µM -0.528498904219524 0.295201373945039 no 2377 0.2985765537107 3427 1549252
SGTC_640 3381-0960 37.1 µM -0.529954454020786 0.294671233345602 no 2378 0.298071754906275 3408 1745025
SGTC_701 4424-0219 185 µM -0.531271408484853 0.294191950700819 no 2379 0.297615357698919 3466 2911779
SGTC_3008 9078912 71.4286 µM -0.531324998427209 0.294172455202943 no 2380 0.297596792589452 3355 16648731
SGTC_3123 9126162 49.47 µM -0.531382646562063 0.294151484040731 no 2381 0.297576822194637 3363 25239884
SGTC_1475 4092-1048 11.7 µM -0.531565356843309 0.294085022501257 no 2382 0.29751353196961 3419 2881759
SGTC_298 1391-0729 10 µM -0.531601575395611 0.294071848693435 no 2383 0.297500986715216 3358 3237558
SGTC_26 0302-0163 425.158 µM -0.532586393299173 0.293713744550286 no 2384 0.29715996157882 3366 3100915
SGTC_3180 9109287 49.47 µM -0.533030655373418 0.293552265956708 no 2385 0.297006179943344 3417 18891271
SGTC_206 4546-0025 72.014 µM -0.533550744168613 0.293363278421964 no 2386 0.296826197100199 3431 6620745 YIL048W NEO1
SGTC_35 0133-0054 64.071 µM -0.534324979230795 0.293082044837678 no 2387 0.296558356466234 3349 99677
SGTC_1461 k072-0203 53.8 µM -0.535757793388929 0.292561918722729 no 2388 0.296062977778727 3342 5418714
SGTC_1830 st055982 50.3 µM -0.536971408882972 0.292121699750704 no 2389 0.295643681774137 3419 455313 An antimicrobial agent.
SGTC_3213 9129884 49.47 µM -0.538205166478027 0.291674490812203 no 2390 0.295217706805712 3371 17190742
SGTC_2232 chlorophetanol 41.5365 µM -0.538525298684766 0.291558502367901 no 2391 0.295107222115807 3449 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_980 1473-0395 201 µM -0.539503820220032 0.291204103533015 no 2392 0.294769630851715 3356 768876
SGTC_863 0466-0191 129 µM -0.54001245659646 0.291019966177071 no 2393 0.294594220971448 3420 765160 YPR165W RHO1
SGTC_3324 9138759 60.749 µM -0.541698466923376 0.290409983350615 no 2394 0.29401312302139 3441 45595710
SGTC_416 estradiol valerate 100 µM -0.54182790620731 0.290363178174943 no 2395 0.293968532571306 3439 13791 A steroid.
SGTC_184 1494-0393 24.714 µM -0.54195064623642 0.290318798709203 no 2396 0.293926252831512 3325 3090647
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.542680709899924 0.290054893150745 no 2397 0.293674829010675 3406 6312947
SGTC_43 0570-0105 72.5 µM -0.543956672339171 0.289593924701664 no 2398 0.293235644401786 3429 1114046 YDL195W SEC31
SGTC_1097 itavastatin 7.23 µM -0.544213074234817 0.289501335605238 no 2399 0.293147427955758 3426 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3081 9117243 49.47 µM -0.544760428546204 0.289303727430535 no 2400 0.292959148961431 3480 45595589
SGTC_2097 5376186 200 µM -0.545262127477023 0.289122657652325 no 2401 0.29278662381311 3429 742755
SGTC_311 1315-0136 58 µM -0.546733175459045 0.288592044431181 no 2402 0.292281029282821 3485 6759207
SGTC_293 4049-0273 38.5 µM -0.548132756118958 0.288087636046383 no 2403 0.291800375163051 3370 1380311
SGTC_1380 2291-0730 164 µM -0.549756790312717 0.287502856696937 no 2404 0.291243099634008 3374 2999191
SGTC_642 0335-0876 158 µM -0.550001761649375 0.287414696594225 no 2405 0.291159082641811 3425 6812350
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.550060274182645 0.287393641039185 no 2406 0.291139016470425 3502 5393153
SGTC_1756 st041558 35.5 µM -0.551323588017974 0.286939219479861 no 2407 0.290705935722909 3513 3955792
SGTC_1608 st001473 40.5 µM -0.551861822166767 0.286745716893755 no 2408 0.290521513487095 3341 7292267
SGTC_2552 juarezic acid 87.02 µM -0.552253613183154 0.286604901545663 no 2409 0.290387303428139 3470 1549512
SGTC_268 camptothecin 39.6153 µM -0.553020894817307 0.286329224499351 no 2410 0.29012455122209 3459 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_146 3448-8650 53.125 µM -0.553069969676106 0.286311596650013 no 2411 0.290107749545061 3387 2891488 YIL048W NEO1
SGTC_2869 9037858 32.47 µM -0.553800832637094 0.28604912928619 no 2412 0.289857579203012 3422 27187042
SGTC_2222 6885208 172.143 µM -0.554588502177731 0.285766389627912 no 2413 0.289588077631534 3416 609514
SGTC_3304 9125678 46.087 µM -0.556068191726519 0.285235604093844 no 2414 0.289082119360457 3385 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_775 4577-0580 57.3 µM -0.556532618255401 0.285069104653163 no 2415 0.288923401246037 3534 2006902
SGTC_1354 1498-1681 81 µM -0.557991062388277 0.284546545927749 no 2416 0.288425243637272 3448 5754243
SGTC_1609 st001574 46.4 µM -0.558732781431764 0.284280964520697 no 2417 0.288172051672016 3367 3960012
SGTC_753 1322-0200 289 µM -0.558948128795816 0.284203879012716 no 2418 0.288098560704373 3497 5403907
SGTC_2102 5377816 72.7585 µM -0.560983724990148 0.283475713392126 no 2419 0.28740431603091 3506 1379702
SGTC_925 2064-1272 59.6 µM -0.561323006909085 0.283354433767567 no 2420 0.287288680150238 3371 6815817
SGTC_722 3534-0461 190 µM -0.562007919198218 0.283109681035917 no 2421 0.287055311780243 3425 658262
SGTC_539 4859-0462 2.54 µM -0.562775039005869 0.282835672032632 no 2422 0.286794039690367 3470 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1220 1838-0075 193 µM -0.564380720869332 0.282262548126288 no 2423 0.286247528293051 3434 5529645
SGTC_707 0865-0008 204 µM -0.56501314707924 0.282036966644664 no 2424 0.286032410943424 3432 723043
SGTC_850 0388-0143 75.9 µM -0.565156756511987 0.281985754381879 no 2425 0.285983573450918 3385 67273
SGTC_872 0588-0139 234 µM -0.56555895294444 0.281842351786301 no 2426 0.285846818955027 3461 2047100
SGTC_2467 5474540 200 µM -0.56872881636371 0.280713372906133 no 2427 0.284770094423688 3424 5413519
SGTC_2885 9057732 51.95 µM -0.568924573131708 0.280643723930056 no 2428 0.28470366417732 3505 6471414
SGTC_1127 asiatic acid 681.4 nM -0.569504310662093 0.280437506168818 no 2429 0.284506973095732 3385 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3107 9121808 49.47 µM -0.570453963668811 0.280099864789226 no 2430 0.2841849188505 3452 662681
SGTC_2608 thymoquinone 42.66 µM -0.570802671811906 0.279975933925807 no 2431 0.284066705809243 3447 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_624 k048-0052 28 µM -0.571041159468747 0.279891190731385 no 2432 0.283985871369915 3417 6835531
SGTC_3300 9124615 50.48 µM -0.571305129524376 0.279797407236047 no 2433 0.283896412608265 3536 24824903
SGTC_2849 9019321 12.99 µM -0.571646062074989 0.279676303007157 no 2434 0.283780891421981 3452 16489627
SGTC_2743 auranofin 4.32 µM -0.57165266482802 0.279673957863826 no 2435 0.28377865437506 3397 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1842 st055362 61.2 µM -0.572276292563792 0.279452502917924 no 2436 0.283567404138403 3437 676032
SGTC_1546 5-methoxyflavanone 78.7 µM -0.572603084599218 0.279336490600294 no 2437 0.283456735349538 3504 147795
SGTC_2817 7995342 71.43 µM -0.572894174232384 0.279233172468764 no 2438 0.283358174688604 3343 18879975
SGTC_1035 k081-0041 55.2 µM -0.574810448965519 0.278553481926443 no 2439 0.282709749612089 3524 731709
SGTC_2684 capsaicin 100 µM -0.57585401162166 0.278183676073227 no 2440 0.282356931162414 3491 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_89 0302-0250 142.109 µM -0.576218994994735 0.278054393955702 no 2441 0.282233583827625 3537 4203518 YLR208W SEC13
SGTC_197 4544-0043 41.561 µM -0.576288614192779 0.27802973720997 no 2442 0.282210058735388 3462 896523
SGTC_2247 cerulenin 830 nM -0.576301907481429 0.278025029301768 no 2443 0.282205566894352 3561 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2323 6148992 148.28 µM -0.580497281053628 0.276541155766264 no 2444 0.280789659885827 3396 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3179 9107801 49.47 µM -0.580673763544412 0.276478820373168 no 2445 0.280730173744849 3457 4818259
SGTC_2364 9055074 200 µM -0.581400644766313 0.276222151256071 no 2446 0.280485231506982 3461 6470630
SGTC_103 0844-0104 51.839 µM -0.581930913597517 0.276034981760973 no 2447 0.280306608402167 3550 5375804
SGTC_2667 digitoxin 100 µM -0.584121687185465 0.275262363101557 no 2448 0.279569222403444 3464 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_717 1532-0246 73.2 µM -0.584157947348737 0.275249584214615 no 2449 0.279557025629185 3453 9561992
SGTC_546 peri-Naphthalide 147 µM -0.585705637756407 0.274704416152703 no 2450 0.279036672414876 3406 223824 A penicillin ester.
SGTC_2333 9017922 200 µM -0.585735960921588 0.27469374025359 no 2451 0.279026482087364 3502 3163164
SGTC_1332 1480-0653 17.5 µM -0.586028077590372 0.274590905003222 no 2452 0.278928323356868 3477 5749438
SGTC_409 arachidonic acid 100 µM -0.587316969280876 0.274137397075617 no 2453 0.278495423220288 3489 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2379 9035213 200 µM -0.587449860620126 0.274090659133815 no 2454 0.278450807618023 3508 646551
SGTC_1257 0669-0121 16 µM -0.588043869362014 0.273881794142076 no 2455 0.278251423679599 3498 4307855
SGTC_788 1182-0090 188 µM -0.588144714646026 0.273846342799838 no 2456 0.278217581040499 3568 5715185
SGTC_288 1315-0019 35.1 µM -0.58980827854131 0.273261858041237 no 2457 0.27765959595162 3522 6811474
SGTC_2009 4012297 12.05 µM -0.591548118246044 0.272651236004911 no 2458 0.277076612219691 3478 45595307
SGTC_510 ag-490 170 µM -0.593398225213219 0.272002657878188 no 2459 0.276457338184426 3593 5328779
SGTC_3240 9133527 49.47 µM -0.593621864474359 0.271924310349672 no 2460 0.276382526903275 3492 17617455
SGTC_321 4534-3890 65.3 µM -0.59385333116298 0.271843232462694 no 2461 0.276305107668011 3500 699746
SGTC_1402 3909-7673 35.9 µM -0.594226119131692 0.271712678010382 no 2462 0.276180442725934 3494 5328014
SGTC_2728 chlorpromazine 9.18 µM -0.595981063559469 0.271098496747446 no 2463 0.27559393859466 3493 2726 A thorazine and dopamine antagonist.
SGTC_3306 9127676 59.7925 µM -0.597106243998527 0.27070507978528 no 2464 0.275218224690927 3474 41905287
SGTC_319 1348-1596 45.5 µM -0.601384050399464 0.26921196088024 no 2465 0.273792109696552 3566 5380505
SGTC_2219 9098279 200 µM -0.601803606861678 0.269065742309325 no 2466 0.273652436971788 3506 902349
SGTC_2113 5491891 107.031 µM -0.601934380951987 0.269020174707775 no 2467 0.273608908743381 3505 789979
SGTC_433 pimozide 108 µM -0.603202876403726 0.268578374684796 no 2468 0.273186867204968 3404 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_168 3970-0862 530.542 µM -0.605618489459802 0.267738058583162 no 2469 0.272384060825848 3529 3135186
SGTC_3083 9117465 49.47 µM -0.605962770491163 0.267618401952106 no 2470 0.272269737732096 3523 16420915
SGTC_3253 9135987 49.47 µM -0.608619743351106 0.266695865164863 no 2471 0.271388257411288 3515 4182430
SGTC_2808 7946468 45.46 µM -0.608959662117687 0.266577956880213 no 2472 0.27127558825769 3503 2970879
SGTC_1429 4049-0205 9.46 µM -0.610275622512882 0.26612173583568 no 2473 0.270839621235574 3562 22774478
SGTC_22 0964-0034 14.468 µM -0.610489483621818 0.266047631197916 no 2474 0.270768803829732 3517 138402
SGTC_1313 1220-0047 237 µM -0.611024827090868 0.265862176109538 no 2475 0.27059157214197 3530 3528706
SGTC_3007 9078383 71.4286 µM -0.611293907196594 0.265768985420108 no 2476 0.270502511927775 3502 6496995
SGTC_3198 9112019 49.47 µM -0.611897991488591 0.265559832843352 no 2477 0.270302625289118 3547 45595555
SGTC_2272 7805186 180 µM -0.614867089462215 0.264533054807971 no 2478 0.269321249316808 3531 2956062 YPR165W RHO1
SGTC_1093 fluphenazine 7.97 µM -0.615866414289297 0.264187921664051 no 2479 0.268991344823183 3575 6602611 An atypical antipsychotic.
SGTC_2762 leflunomide 42.06 µM -0.615914585060569 0.264171290897693 no 2480 0.268975447458617 3542 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3005 9076496 71.4286 µM -0.616364643379571 0.264015935830271 no 2481 0.268826941568491 3559 21368410
SGTC_70 0141-0289 43.283 µM -0.618265443594157 0.263360314932498 no 2482 0.268200188467835 3543 352408
SGTC_1693 xanthone 101.9 µM -0.618642480272625 0.263230366927248 no 2483 0.268075955163462 3537 7020 An insecticide.
SGTC_1253 0550-0034 176 µM -0.620423199520577 0.262617074040994 no 2484 0.267489601253564 3527 5969915
SGTC_2127 5253358 187.912 µM -0.620485784305172 0.262595532686406 no 2485 0.267469005152907 3499 20612
SGTC_2886 9058944 51.95 µM -0.621042725629876 0.262403876239403 no 2486 0.267285755907767 3398 4949929
SGTC_1196 1588-0294 184 µM -0.621269824309542 0.26232574687103 no 2487 0.267211052288497 3529 6144269
SGTC_1319 1306-0155 43.7 µM -0.621834589130353 0.262131500983357 no 2488 0.267025319822406 3573 3122360
SGTC_1177 0983-0204 23.6 µM -0.622062183111998 0.262053242879517 no 2489 0.266950490125235 3581 766818
SGTC_2771 fluoxetine 41.05 µM -0.62250046586667 0.261902573264623 no 2490 0.266806418770017 3570 3386 A selective serotonin reuptake inhibitor.
SGTC_2117 5521686 200 µM -0.622904693355803 0.261763650308454 no 2491 0.266673576827059 3535 803312
SGTC_440 fluspirilene 35.1 µM -0.623743924582053 0.261475348129027 no 2492 0.266397885704545 3644 3396 An atypical antipsychotic.
SGTC_1085 doxorubicin 7.67 µM -0.624928275578114 0.261068764084389 no 2493 0.266009066732002 3577 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3043 9092303 49.47 µM -0.62495986319611 0.261057924603907 no 2494 0.265998700546342 3505 25236084
SGTC_2671 danthron 100 µM -0.625221697370529 0.260968083545514 no 2495 0.265912781665545 3511 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.626692913406736 0.260463572804662 no 2496 0.265430275011632 3508 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1014 4130-3005 69.3 µM -0.627435929107407 0.260208968209923 no 2497 0.265186761182372 3563 743608
SGTC_2381 9035592 200 µM -0.627532702027127 0.260175817075181 no 2498 0.265155053456054 3516 4749657
SGTC_1730 st033808 45.1 µM -0.629567888589225 0.259479135511157 no 2499 0.264488669246176 3548 1045166
SGTC_647 0140-0236 81 µM -0.629717257614586 0.25942804174141 no 2500 0.264439794711107 3575 990837
SGTC_348 k064-0012 10.7 µM -0.630347832953074 0.259212401897124 no 2501 0.26423351695503 3501 5066323
SGTC_2316 5844804 197.44 µM -0.630940827793687 0.259009698135513 no 2502 0.264039607558703 3596 776813
SGTC_178 4092-0806 87.505 µM -0.631203613264204 0.258919896251103 no 2503 0.26395369986514 3562 2169044
SGTC_804 1595-0054 20.9 µM -0.633914757769625 0.257994355887636 no 2504 0.263068226947117 3540 761523 Stimulates phospholipase C.
SGTC_975 1335-0046 28.5 µM -0.634057123679923 0.257945801963288 no 2505 0.263021771535802 3522 16486740
SGTC_61 0978-8327 98.565 µM -0.634930004282453 0.257648209513865 no 2506 0.26273703361357 3581 6150059 YHR072W ERG7
SGTC_395 anisomycin 6.25 µM -0.635352319981264 0.257504292825969 no 2507 0.262599328787857 3537 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1810 st050138 53 µM -0.636973466982387 0.256952226623762 no 2508 0.262071063291591 3581 3444541
SGTC_3121 9125696 49.47 µM -0.63724767565811 0.256858908390105 no 2509 0.261981763787762 3609 1235365
SGTC_231 b-estradiol 524 µM -0.638102291314947 0.256568180216831 no 2510 0.261703547562478 3520 450 A steroid.
SGTC_2914 7968218 45.32 µM -0.639379138599226 0.25613413435111 no 2511 0.261288158394265 3534 2977111
SGTC_2607 solasodine 47.35 µM -0.640684072541285 0.255690936814345 no 2512 0.260863982210697 3569 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_895 0964-0006 13.7 µM -0.640703082135945 0.255684483505051 no 2513 0.260857805652622 3580 6738897
SGTC_2586 curcumin 80 µM -0.640814523851203 0.255646653380431 no 2514 0.26082159775484 3583 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1092 toremifene 6.32 µM -0.640915629245263 0.255612334563631 no 2515 0.260788750409776 3599 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_166 k072-0058 166.424 µM -0.644199045704856 0.254499133855074 no 2516 0.25972318482797 3607 5846229
SGTC_1711 st032263 62.8 µM -0.645804328177102 0.253955809161427 no 2517 0.259203042318208 3577 3958979
SGTC_367 0335-0881 7.1 µM -0.646418757990105 0.253748010135413 no 2518 0.259004097776898 3569 23828853
SGTC_1222 0366-0074 1.18 µM -0.646989208467558 0.25355516479025 no 2519 0.25881946390414 3622 286520
SGTC_3078 9116413 49.47 µM -0.64831914969546 0.253105866703232 no 2520 0.25838927540322 3545 17177322
SGTC_1849 st056239 19.2 µM -0.649351371831901 0.252757436840725 no 2521 0.258055643928521 3496 5393181
SGTC_295 k015-0027 31 µM -0.649401011223324 0.252740687273478 no 2522 0.258039605278299 3560 3887424
SGTC_3166 9102297 49.47 µM -0.653462726670121 0.251372146157774 no 2523 0.25672900568228 3574 25237072
SGTC_2712 st079126 47.7 µM -0.654289555249289 0.251094037878323 no 2524 0.256462636875581 3576 3152970
SGTC_601 0986-0029 62.9 µM -0.654510458028288 0.251019763592237 no 2525 0.256391495829427 3610 24747981
SGTC_815 1582-0027 36.9 µM -0.655860793197707 0.250565992355556 no 2526 0.255956848295552 3618 3128206
SGTC_2126 5251174 33.877 µM -0.656019955312046 0.250512535621007 no 2527 0.255905642339791 3631 790722
SGTC_2387 9077560 195.08 µM -0.656062526153159 0.250498238656437 no 2528 0.255891947269299 3581 5303272
SGTC_2109 5483026 200 µM -0.65632845579943 0.250408938798013 no 2529 0.255806406166919 3624 759335
SGTC_1391 3442-0225 151 µM -0.656955083407171 0.250198582378694 no 2530 0.255604899052544 3570 5227075
SGTC_2250 alverine citrate 130 µM -0.657160944908543 0.250129495940517 no 2531 0.255538717453248 3547 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1956 st077085 54 µM -0.657547849953237 0.249999679274407 no 2532 0.255414357107958 3594 24208685
SGTC_2861 9024595 19.48 µM -0.657940733048311 0.249867893410486 no 2533 0.255288107648547 3560 16482810
SGTC_1183 1254-0324 198 µM -0.658860212216808 0.249559614167454 no 2534 0.254992768827203 3624 5799357
SGTC_3347 9188721 44.724 µM -0.659055276755795 0.249494239711989 no 2535 0.25493013664214 3599 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2724 maprotiline 69.64 µM -0.659549158309752 0.249328759613179 no 2536 0.25477159497021 3602 4011 A tricyclic antidepressant.
SGTC_870 0573-2213 57.6 µM -0.660073580225601 0.249153110545288 no 2537 0.254603306013546 3605 3916321
SGTC_1789 tunicamycin 25 nM -0.660431148709575 0.249033384856296 no 2538 0.254488594341699 3607 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2180 6301957 200 µM -0.662264499493374 0.248419999853215 no 2539 0.253900862074258 3587 845462
SGTC_2521 angolensin 13.4 µM -0.662880372418968 0.248214127794522 no 2540 0.253703586620583 3622 821428 A flavenoid.
SGTC_2157 5649910 96.377 µM -0.664148768540426 0.247790419145749 no 2541 0.253297549688376 3595 2858091
SGTC_2280 7785178 200 µM -0.664788377470192 0.24757690386716 no 2542 0.253092928755938 3610 2954328
SGTC_1082 camptothecin 424.86 nM -0.664824489292207 0.24756485189269 no 2543 0.253081378611282 3558 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1800 st050079 29.0735 µM -0.665314654972799 0.247401294799432 no 2544 0.252924629556259 3591 3645560
SGTC_1757 st041620 31.8375 µM -0.6653990654673 0.247373134775379 no 2545 0.252897641259269 3631 5289815
SGTC_2202 7226349 200 µM -0.66637316485457 0.247048291337258 no 2546 0.252586305287436 3577 844334
SGTC_610 4215-0184 155 µM -0.668431881753722 0.246362500305112 no 2547 0.251928975068842 3644 5605015
SGTC_404 fumagillin 50 µM -0.669090302558604 0.24614338551234 no 2548 0.251718937795801 3610 12015870 A methionine aminopeptidase binder.
SGTC_1697 st025554 27.742 µM -0.669811747392772 0.245903417109506 no 2549 0.251488901976526 3605 1269519
SGTC_583 1488-1091 88.9 µM -0.670561093898085 0.245654300988853 no 2550 0.251250087253184 3714 4303273
SGTC_2043 5101342 149 µM -0.671182357292752 0.245447868200375 no 2551 0.251052183234338 3616 678451
SGTC_82 0054-0107 293.755 µM -0.671186868880517 0.245446369435429 no 2552 0.251050746365655 3639 3104697
SGTC_486 niguldipine 82 µM -0.672379362870832 0.245050391325262 no 2553 0.250671108679624 3629 1236 A calcium channel blocker.
SGTC_2755 lomerizine 42.69 µM -0.673473102585226 0.244687507788055 no 2554 0.250323177529468 3642 3949 A calcium channel blocker.
SGTC_3286 9117135 37.221 µM -0.6735201998692 0.244671888241032 no 2555 0.250308201094983 3597 3438150
SGTC_2007 4011539 71.82 µM -0.67409236911643 0.244482174445032 no 2556 0.250126295318895 3646 45595301
SGTC_1695 st026914 34.495 µM -0.676502385413003 0.24368395751239 no 2557 0.249360866021261 3614 3289191
SGTC_11 0438-0307 1.3 µM -0.678087548759783 0.243159706669054 no 2558 0.248858092449698 3637 4011476
SGTC_1285 0929-0069 65.5 µM -0.678512352642266 0.243019317701697 no 2559 0.248723447183726 3642 1206237
SGTC_2394 5221648 200 µM -0.678939266895468 0.242878275480151 no 2560 0.248588172110997 3700 788586
SGTC_2258 7960471 200 µM -0.679418098555743 0.242720133707888 no 2561 0.248436492766659 3588 2974708
SGTC_1339 1486-1321 22.7 µM -0.679659722515313 0.242640354716779 no 2562 0.248359972354445 3665 3469382
SGTC_520 3584-0023 682 µM -0.6817820057753 0.241940233222371 no 2563 0.247688402044568 3629 1340790
SGTC_1974 st069448 26.9 µM -0.681899239349273 0.241901590922241 no 2564 0.247651333214645 3613 6323587 YNR016C ACC1
SGTC_2461 5755302 26.15 µM -0.682080547182139 0.241841835185 no 2565 0.247594010172216 3642 2788904
SGTC_2006 4011487 200 µM -0.682918972561367 0.241565609740209 no 2566 0.247329022296169 3680 45595294
SGTC_2874 9043904 71.43 µM -0.684537809878747 0.241032756882896 no 2567 0.24681781119568 3615 4463428
SGTC_556 4058-0063 51.5 µM -0.684645770099422 0.240997243686976 no 2568 0.246783738670741 3713 6615692
SGTC_1770 st043884 66.3 µM -0.688255014534177 0.239811632672502 no 2569 0.245646102515251 3653 670149
SGTC_3346 9158254 43.5805 µM -0.689174707830475 0.239510029521436 no 2570 0.245356665529032 3638 17639500
SGTC_1515 3460-0031 42.1 µM -0.689262931518696 0.239481108437875 no 2571 0.245328910260566 3622 2876596
SGTC_2710 st078562 53.7235 µM -0.68983753781259 0.239292790309172 no 2572 0.245148179792172 3639 17250908
SGTC_1797 st048695 56.8 µM -0.691464178129648 0.238760123600693 no 2573 0.244636942363917 3636 592262 YIL048W NEO1
SGTC_1447 4239-0816 81.9 µM -0.691840061492423 0.238637127532643 no 2574 0.244518887551787 3645 1341554
SGTC_2245 6637752 200 µM -0.692673244474653 0.238364618129651 no 2575 0.24425731672381 3642 681890
SGTC_412 gemfibrozil 100 µM -0.693007410568583 0.238255370228594 no 2576 0.244152450470391 3641 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_637 1181-0519 7.26 µM -0.694102838830964 0.237897437618406 no 2577 0.243808859208639 3683 6252091 YGR060W ERG25
SGTC_579 4491-1009 110 µM -0.694931611269174 0.2376268311882 no 2578 0.243549080543657 3795 1271041
SGTC_516 3992-2719 87.3 µM -0.695360895589166 0.237486729952266 no 2579 0.24341458019975 3643 5350887 YDR037W KRS1
SGTC_800 3448-7362 155 µM -0.697163018999656 0.236899083923481 no 2580 0.242850389699087 3752 15991913
SGTC_2594 a-mangostin 100 µM -0.697955839325129 0.236640810262124 no 2581 0.242602405880846 3691 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1978 st071761 42 µM -0.69902337748252 0.236293287810824 no 2582 0.242268710659633 3670 5147680
SGTC_2570 licareol 100 µM -0.699813144564207 0.236036370895974 no 2583 0.242022002383513 3665 443158
SGTC_2154 5570129 200 µM -0.700402873165162 0.235844628359692 no 2584 0.241837871232665 3685 673366
SGTC_600 1495-0418 41.6 µM -0.700445812257892 0.235830670630174 no 2585 0.241824467315362 3680 5377768
SGTC_1156 4092-0367 4.88 µM -0.700610631573573 0.235777098891979 no 2586 0.241773020869071 3693 1357585
SGTC_543 3844-1095 191 µM -0.700997527840271 0.23565137115355 no 2587 0.241652279006814 3688 4230703
SGTC_1935 st074532 41.6 µM -0.701233036397278 0.235574857228812 no 2588 0.241578797968229 3727 2829742
SGTC_2759 disulfiram 3.38 µM -0.701529439255839 0.235478578953066 no 2589 0.241486334541262 3649 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1358 1509-0022 2.48 µM -0.702119855976716 0.235286863118816 no 2590 0.241302210229742 3692 3258434
SGTC_2681 menadione 3.18 µM -0.702600755997613 0.235130772453217 no 2591 0.241152295621451 3699 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1548 st061468 90.8 µM -0.703244375175266 0.234921955881313 no 2592 0.240951734588614 3676 390799
SGTC_2974 9094440 9.66 µM -0.704604736791811 0.234480935937323 no 2593 0.240528124946599 3753 25236134
SGTC_2051 5263410 176 µM -0.704907264624277 0.23438292077578 no 2594 0.240433974477647 3730 227584
SGTC_2809 7964133 12.99 µM -0.70630407214788 0.233930667079151 no 2595 0.239999530796917 3703 1253665
SGTC_2448 5185112 27.17 µM -0.708915611139668 0.233086410114274 no 2596 0.239188423409055 3677 5718189
SGTC_2700 st077718 96.8 µM -0.710002820569833 0.232735437000897 no 2597 0.238851193544177 3688 904970
SGTC_622 1348-1566 26.3 µM -0.710252086152761 0.232655010455043 no 2598 0.238773913180824 3745 7340407
SGTC_1478 0453-0656 35.7 µM -0.711234464666966 0.23233819253342 no 2599 0.238469477410026 3716 5258496
SGTC_2173 5763948 167 µM -0.712136441896801 0.232047515565679 no 2600 0.238190144964495 3705 2867177
SGTC_277 nystatin 15.5 µM -0.712312028528496 0.231990953443312 no 2601 0.238135788565983 3687 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_470 aa-861 153 µM -0.712878506886837 0.231808524821978 no 2602 0.237960470064222 3688 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_258 haloperidol 50.781 µM -0.713295390996198 0.231674322575478 no 2603 0.237831494465041 3717 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1308 1187-1617 41.4 µM -0.714946302751666 0.231143290812234 no 2604 0.23732111213453 3697 2882570
SGTC_2155 5570423 76 µM -0.716891551842055 0.230518455190895 no 2605 0.236720507573527 3667 797402
SGTC_1337 1486-1011 40.3 µM -0.71741039159683 0.230351957714665 no 2606 0.236560454770283 3715 X1337
SGTC_2416 tofa 880 nM -0.719125103472804 0.229802179329912 no 2607 0.236031920592804 3716 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_81 0411-0046 9.971 µM -0.719140068301822 0.229797384477498 no 2608 0.236027310774953 3614 12925265
SGTC_2329 6138490 200 µM -0.719298243252062 0.229746707367814 no 2609 0.235978589047978 3748 720019
SGTC_2083 5306046 65.942 µM -0.719939879866472 0.229541199894256 no 2610 0.235781006238706 3733 539837
SGTC_1867 st057372 64 µM -0.720615488664354 0.229324922958492 no 2611 0.235573060807858 3693 688837
SGTC_752 1896-0090 130 µM -0.720794294124491 0.229267702601371 no 2612 0.235518043264976 3704 772567
SGTC_2382 9035899 200 µM -0.721555726324067 0.229024122833025 no 2613 0.235283833793885 3742 6462679
SGTC_1125 tnp00248 1.32998 µM -0.722032961934274 0.228871530706132 no 2614 0.235137106130968 3817 24207736
SGTC_125 0133-0007 11.75 µM -0.722210813412693 0.228814678769641 no 2615 0.235082438035964 3786 26541
SGTC_2553 4-methylesculetin 85.09 µM -0.723835032497595 0.228295848426861 no 2616 0.234583509556927 3759 5319502
SGTC_1781 st038725 66.3 µM -0.726045393593075 0.227590847970892 no 2617 0.233905471520868 3729 4270275 YIL048W NEO1
SGTC_2426 5582046 32.21 µM -0.727578206805732 0.227102673856485 no 2618 0.233435912617159 3709 2251934
SGTC_1268 0828-0275 2.46 µM -0.729698279932931 0.226428441683695 no 2619 0.232787316378215 3780 745337
SGTC_977 1348-1378 135 µM -0.729966092794338 0.226343351502524 no 2620 0.232705455400598 3718 X977
SGTC_958 1222-0007 33 µM -0.730222246830317 0.22626198249452 no 2621 0.232627173088081 3775 7312461
SGTC_2260 7964312 200 µM -0.730410966351247 0.226202045076095 no 2622 0.232569508561736 3743 231951
SGTC_2443 5493264 126.67 µM -0.730506185970327 0.226171806680874 no 2623 0.232540416579717 3758 5340055
SGTC_1513 0337-0559 19 µM -0.731940985012122 0.225716441685056 no 2624 0.232102294523499 3704 775073
SGTC_1213 1315-0166 115 µM -0.734223081955201 0.224993237721577 no 2625 0.231406393986401 3766 768401
SGTC_1458 k015-0034 6.33 µM -0.734310258593829 0.224965637226194 no 2626 0.231379833514694 3756 3598957
SGTC_1123 mangostin 811.285 nM -0.735196042958761 0.224685302953549 no 2627 0.23111005430138 3744 5281650 An antioxidant.
SGTC_3117 9124945 49.47 µM -0.735515854167164 0.224584137357481 no 2628 0.231012694040594 3655 17592065
SGTC_1966 st070145 16.1 µM -0.73581091059421 0.224490825342138 no 2629 0.230922890197081 3696 3748532
SGTC_1271 0832-2808 169 µM -0.736852021783892 0.224161748269901 no 2630 0.230606171716498 3765 3663794
SGTC_3069 9117009 49.47 µM -0.73777495826666 0.223870253372462 no 2631 0.230325606478522 3652 41904981
SGTC_2429 5902844 64.44 µM -0.739724555207016 0.223255212694927 no 2632 0.229733572679465 3773 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1081 sertraline 6 µM -0.742062991602495 0.222518774776204 no 2633 0.229024585566349 3738 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2965 9082772 38.63 µM -0.743099987879498 0.222192639994037 no 2634 0.228710573494576 3733 16459634
SGTC_2206 7254556 146.969 µM -0.74448337388822 0.221757990797364 no 2635 0.228292048002383 3747 4398905
SGTC_1677 st019204 53.9 µM -0.745740787058358 0.221363343040039 no 2636 0.227912007709403 3769 3945625
SGTC_2905 7799065 20.05 µM -0.746001254989219 0.221281643633674 no 2637 0.227833328462404 3670 1296806
SGTC_2371 9071574 200 µM -0.747680401651209 0.220755369953286 no 2638 0.227326477597894 3725 45596039
SGTC_771 0250-0039 27.3 µM -0.747979472407471 0.220661711252997 no 2639 0.227236269712343 3737 3005115
SGTC_2450 5739737 12.93 µM -0.748973443287893 0.220350597260778 no 2640 0.226936606009428 3776 2262825
SGTC_2662 daunorubicin 22.37 µM -0.750592656422022 0.219844320598212 no 2641 0.22644892101286 3653 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3235 9132602 49.47 µM -0.752737252374507 0.21917480220919 no 2642 0.225803909782486 3764 4912240
SGTC_2474 5321570 43.32 µM -0.753476149106619 0.218944398870204 no 2643 0.225581919240623 3797 2841384
SGTC_2446 5162541 200 µM -0.756990711541974 0.21785039453185 no 2644 0.224527713626305 3740 1549321
SGTC_2853 9015042 58.44 µM -0.760716931781228 0.216693956561938 no 2645 0.223413079693871 3718 6457456
SGTC_3245 9134821 49.47 µM -0.760749350619852 0.216683910931368 no 2646 0.223403395997319 3785 17014901
SGTC_1839 st053978 48 µM -0.76148247963339 0.216456808058289 no 2647 0.223184469852822 3796 3788398
SGTC_2984 9022109 38.96 µM -0.761604680407304 0.216418967072223 no 2648 0.223147990277115 3809 6459207
SGTC_2571 chrysanthemic acid 100 µM -0.765463296962181 0.21522606904706 no 2649 0.221997856980321 3808 2743 An insecticide.
SGTC_1304 1165-0502 251 µM -0.76551794553284 0.21520920179895 no 2650 0.221981592289011 3796 767425
SGTC_1455 4262-0120 131 µM -0.766570791443148 0.214884391357877 no 2651 0.221668373601756 3897 1529587
SGTC_2800 7887935 81.82 µM -0.768504482805366 0.214288576188496 no 2652 0.221093764222996 3789 2961002
SGTC_599 1935-0052 86.5 µM -0.770164860656185 0.213777742938217 no 2653 0.220601052640357 3779 9557311
SGTC_2292 7671323 168.05 µM -0.770677586649779 0.213620140660106 no 2654 0.220449030129391 3808 937504
SGTC_827 3253-0474 693 µM -0.771276086476585 0.21343625878142 no 2655 0.220271651773491 3765 5402065
SGTC_2930 9013230 14.89 µM -0.771989955674968 0.213217051744311 no 2656 0.220060188264641 3797 2995857
SGTC_719 2810-4230 27.3 µM -0.772823809263968 0.212961167552191 no 2657 0.219813330308895 3775 721079
SGTC_1678 st019265 80.2 µM -0.773020475650129 0.212900842772525 no 2658 0.219755131437138 3771 5367020
SGTC_3263 9137018 49.47 µM -0.773539189703016 0.21274178203255 no 2659 0.219601672443951 3779 43844957
SGTC_1477 0139-0234 16 µM -0.773824248702858 0.212654399845758 no 2660 0.219517365356135 3803 620880
SGTC_970 1315-0089 19.5 µM -0.774057150256542 0.212583021599225 no 2661 0.219448497798147 3749 6811083 YLR033W RSC58
SGTC_1305 1181-0477 144 µM -0.774539080628141 0.212435366962992 no 2662 0.219306033372568 3808 6252086
SGTC_842 0271-0008 11.1 µM -0.776176745499788 0.211934064421816 no 2663 0.218822317292594 3858 1221709
SGTC_844 0330-0132 15.3 µM -0.77751739271446 0.211524196981988 no 2664 0.218426788523721 3819 2828079
SGTC_2616 abietic acid 100 µM -0.777859628808859 0.211419641752644 no 2665 0.218325885228171 3795 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_468 gf-109203x 121 µM -0.778268362056042 0.211294810903008 no 2666 0.218205411415216 3746 2396 A protein kinase C inhibitor.
SGTC_2045 5106652 78.05 µM -0.778426351632922 0.211246571022824 no 2667 0.218158854375372 3785 673349
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.778807274989537 0.211130288007531 no 2668 0.21804662580657 3727 756377
SGTC_2351 9026858 72.31 µM -0.779965875692937 0.210776837049821 no 2669 0.217705480674596 3743 1409300
SGTC_155 k072-0202 43.6 µM -0.780603634589658 0.210582425982757 no 2670 0.217517826716616 3729 5857737
SGTC_629 3448-6466 76.7 µM -0.780740585903944 0.210540692192537 no 2671 0.217477542389535 3804 573744
SGTC_3027 9089541 49.47 µM -0.783876740610191 0.20958632664174 no 2672 0.216556219465486 3792 9943819
SGTC_2135 5326629 150.42 µM -0.783892695147079 0.20958147801913 no 2673 0.216551538206563 3778 5020077
SGTC_653 0203-0016 55.2 µM -0.783983991532281 0.209553734094324 no 2674 0.216524751841335 3840 295302
SGTC_2298 7976326 193.81 µM -0.786672089771014 0.2087378205203 no 2675 0.215736923256854 3691 2235818
SGTC_2952 9073731 13.78 µM -0.790874543183049 0.207466015727048 no 2676 0.214508602477196 3881 16457353
SGTC_3054 9094397 49.47 µM -0.79138146661875 0.207312913695385 no 2677 0.214360710861292 3835 2598354
SGTC_2941 9056145 11.23 µM -0.791646232133669 0.207232975249749 no 2678 0.214283490824774 3690 2119517
SGTC_2951 9072950 58.06 µM -0.791663166276638 0.207227863085394 no 2679 0.214278552457509 3820 16488155
SGTC_2078 5212016 200 µM -0.792953838187665 0.206838448060698 no 2680 0.213902359091455 3720 1899708
SGTC_1036 k216-0215 33.5 µM -0.79300609236087 0.206822691323864 no 2681 0.213887136621668 3818 622330
SGTC_117 lucigenin 22.078 µM -0.793856273229697 0.20656642740766 no 2682 0.213639554074968 3845 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2121 5257820 149.641 µM -0.79499417901203 0.206223731113975 no 2683 0.213308444108269 3885 791256
SGTC_1348 1493-0373 93.8 µM -0.797493939794853 0.205472077501071 no 2684 0.212582110525393 3831 3010129
SGTC_300 r073-0011 5.04 µM -0.799969908774804 0.204729183897395 no 2685 0.211864115862072 3833 2735780
SGTC_2215 7188065 200 µM -0.800224735197255 0.204652816161958 no 2686 0.211790300547795 3828 940217
SGTC_703 3875-0075 71.8 µM -0.800323528006772 0.20462321396751 no 2687 0.211761687382191 3862 2850814
SGTC_582 0987-0078 156 µM -0.80044914269912 0.204585578565743 no 2688 0.211725309114745 3882 1625765
SGTC_1120 ficusin 1.78878 µM -0.801254667509052 0.204344333289909 no 2689 0.211492114450656 3938 6199 A DNA cross-linker.
SGTC_1740 st038286 13.222 µM -0.801987025493226 0.204125147676295 no 2690 0.211280231731118 3869 716786
SGTC_3026 9090633 49.47 µM -0.802750234766115 0.203896877733083 no 2691 0.211059555630387 3848 25236842
SGTC_672 1441-0018 53.7 µM -0.804571058922026 0.20335289820225 no 2692 0.210533624269967 3832 251141
SGTC_2836 9010338 19.48 µM -0.806628578866074 0.202739248026423 no 2693 0.209940251691079 3842 2994051
SGTC_2854 9024559 71.43 µM -0.807604039596063 0.202448706362327 no 2694 0.209659280262187 3880 3163529
SGTC_2576 guaiol 23.12 µM -0.807718688507474 0.202414574460904 no 2695 0.209626271351643 3844 227829
SGTC_2776 terbinafine 19.92 µM -0.80916018901626 0.201985721871818 no 2696 0.209211505501797 3857 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_554 4483-2211 187 µM -0.809179549966513 0.201979965609753 no 2697 0.209205938026451 3886 747107
SGTC_639 0833-0042 114 µM -0.809454768032821 0.201898150321673 no 2698 0.209126805176455 3825 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2580 diallyl disulphide 81.36 µM -0.810860125444358 0.201480682941913 no 2699 0.208723000684867 3868 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1572 epiandrosterone 68.9 µM -0.812041165596575 0.201130250281234 no 2700 0.208384005404183 3767 441302 A steroid.
SGTC_2747 doxorubicin 7.63 µM -0.81416286365179 0.200501628947012 no 2701 0.207775828392856 3745 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2479 5617353 43.85 µM -0.814308003318507 0.200458669811769 no 2702 0.207734262984415 3873 2731746
SGTC_2680 butyl paraben 22.24 µM -0.814612065375193 0.200368689988877 no 2703 0.207647200967211 3901 7184 An antifungal and steroid mimetic.
SGTC_1104 tacrolimus 29.8 µM -0.814708909802362 0.2003400363148 no 2704 0.207619476052444 3886 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1185 1319-0113 81.3 µM -0.814832036758549 0.200303609898581 no 2705 0.207584230054416 3910 4672763
SGTC_2937 9044753 11.33 µM -0.815228586627672 0.200186319903554 no 2706 0.207470738767513 3837 6465530 YGL099W LSG1
SGTC_1485 3909-9022 254 µM -0.815597276171826 0.200077307364899 no 2707 0.20736525392321 3892 714516
SGTC_3128 9127691 49.47 µM -0.81681386581673 0.199717844608909 no 2708 0.207017403513747 3890 41316314
SGTC_1919 st067113 52.3 µM -0.818218543358744 0.199303291625501 no 2709 0.206616204292466 3906 1268243
SGTC_3101 9120531 49.47 µM -0.819240484153994 0.199002019026878 no 2710 0.206324610625142 3868 24824904
SGTC_91 0417-1751 58.384 µM -0.820479372816052 0.198637157479971 no 2711 0.205971441761037 3954 6795624
SGTC_1004 4084-0029 199 µM -0.820510109086245 0.198628110560885 no 2712 0.205962684361069 3896 716894 YLR208W SEC13
SGTC_1439 4092-1168 46 µM -0.821163566377357 0.198435830635829 no 2713 0.205776553109071 3864 2886240
SGTC_1063 disulfiram 1.84 µM -0.821177774823382 0.198431651045924 no 2714 0.205772507073988 3846 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2456 5770359 74.46 µM -0.821353800967931 0.198379875186512 no 2715 0.205722385313655 3866 3118787
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.822943831129921 0.19791255746488 no 2716 0.205269967843715 3877 91467 include heat shock
SGTC_530 4358-1714 28 µM -0.823241978410797 0.19782500459926 no 2717 0.205185200692823 3915 1564641
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.824527293471855 0.197447831537244 no 2718 0.204820007083667 3832 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_21 0849-0113 22.993 µM -0.824961192643336 0.197320602956757 no 2719 0.204696811634186 3815 1560156
SGTC_3269 9137823 49.47 µM -0.825120836307793 0.197273804478037 no 2720 0.204651495670797 3783 17682936
SGTC_107 0358-0022 2.6945 µM -0.82825300845824 0.196356987739818 no 2721 0.203763614671524 3909 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2480 5767542 37.17 µM -0.82939385267726 0.196023694444716 no 2722 0.203440789432672 3858 2867358
SGTC_2056 5235370 200 µM -0.831038880988527 0.195543710300197 no 2723 0.202975832539969 3854 5511916
SGTC_75 0159-0059 199.013 µM -0.83314271623174 0.194930897172055 no 2724 0.202382122456153 3913 5377270
SGTC_1531 st059297 52.4 µM -0.834711190724498 0.194474786705284 no 2725 0.201940169642907 3894 7566702
SGTC_1604 st002052 72.4 µM -0.8353603271834 0.194286208830598 no 2726 0.201757430066973 3935 6254834 YHR062C RPP1
SGTC_3108 9121785 49.47 µM -0.836324180256742 0.194006409468715 no 2727 0.201486276809157 3751 17140271
SGTC_1581 himbacine 57.9 µM -0.837299141862879 0.193723635307162 no 2728 0.201212220753328 3880 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1466 k213-0079 57.5 µM -0.837611005213376 0.193633236717959 no 2729 0.201124604976879 3832 3657981
SGTC_1806 st050005 60.3 µM -0.837623399573038 0.193629644545782 no 2730 0.201121123343027 3903 5194765
SGTC_1818 st052136 56.3 µM -0.838658360690821 0.193329832261163 no 2731 0.200830525443319 3726 674169
SGTC_791 1348-1292 225 µM -0.839122540845242 0.193195458490997 no 2732 0.200700274149929 3862 5437054
SGTC_1045 1348-1485 165 µM -0.839842738596843 0.192987084026631 no 2733 0.200498283433409 3907 6810614
SGTC_2640 pentamidine 10.38 µM -0.840133039973631 0.192903130096589 no 2734 0.200416898411313 3897 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3200 9114385 49.47 µM -0.840463648429235 0.192807546702795 no 2735 0.200324237605776 3930 17018030 YLR208W SEC13
SGTC_1921 5740136 50 µM -0.841937705675798 0.192381728942311 no 2736 0.19991141166206 3800 1774243
SGTC_3186 9110464 49.47 µM -0.842366082868671 0.19225808955767 no 2737 0.199791535927933 3889 17018021
SGTC_1034 k072-0165 12.7 µM -0.842797713502798 0.192133560325613 no 2738 0.199670793504353 3924 5835461
SGTC_480 am 92016 50 µM -0.84359398878459 0.191903957440626 no 2739 0.199448162258896 3850 2129 K+ channel blocker.
SGTC_1724 st037281 8.293 µM -0.844120205625397 0.191752317069797 no 2740 0.199301118909686 3895 574124 YDL195W SEC31
SGTC_46 0329-0187a 2.197 µM -0.844483857224701 0.191647566153361 no 2741 0.199199540118053 3962 46494817
SGTC_1545 lovastatin 49.4 µM -0.844663733052863 0.19159576534819 no 2742 0.199149306936875 3986 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_5 0352-0601 109.883 µM -0.844887178612973 0.191531429237201 no 2743 0.199086916844529 3815 762456
SGTC_2347 9049783 174.81 µM -0.845707556588584 0.191295333415221 no 2744 0.198857953294919 3937 6467988 YPL169C MEX67
SGTC_1612 st002233 45.4 µM -0.846201238136557 0.191153343268133 no 2745 0.198720245678996 3886 1035021
SGTC_1169 aniline yellow 25.8 µM -0.849779618157462 0.190126080847499 no 2746 0.197723811681974 3845 6051 A DNA damaging agent.
SGTC_1565 sinapyl alcohol 95.1 µM -0.850650414577914 0.189876611365405 no 2747 0.197481787683202 3945 5280507 A phenol propionate derived from cinnamic acid.
SGTC_553 k007-0256 45.7 µM -0.851560456632635 0.189616113803159 no 2748 0.197229047494628 3954 6287000
SGTC_3293 9120939 62.045 µM -0.852464753834461 0.189357478586834 no 2749 0.196978096723944 3884 934087
SGTC_250 brefeldin a 552.239 µM -0.852669333773872 0.189298997450746 no 2750 0.196921350734397 3777 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3307 9126885 69.2785 µM -0.854515624819764 0.188771720556987 no 2751 0.196409677895881 3890 24824909
SGTC_2398 5228213 48.84 µM -0.854661388553117 0.188730130903497 no 2752 0.196369315935976 3912 80771 YMR134W ERG29
SGTC_3031 9088762 49.47 µM -0.856293849337845 0.188264739217877 no 2753 0.195917631268511 3875 205253
SGTC_1626 st003712 1.76 µM -0.859743659374462 0.187283578499513 no 2754 0.194965181193229 3921 24207035
SGTC_1161 k007-0610 110 µM -0.865685675861072 0.18560103797961 no 2755 0.193331278663464 3910 5843850
SGTC_825 1988-2224 89.6 µM -0.866056278570325 0.185496409845102 no 2756 0.193229649979778 3917 1180859
SGTC_2661 dactinomycin 12.96 µM -0.866323009190759 0.185421129419854 no 2757 0.193156525846465 3905 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_289 k017-0060 526 µM -0.868045952308282 0.184935313480902 no 2758 0.192684588518681 3904 5512909
SGTC_1320 1313-0481 95.3 µM -0.868470298796409 0.184815782578117 no 2759 0.192568462532541 3923 6813365 YLR208W SEC13
SGTC_2947 9072639 7.68 µM -0.868488666965616 0.184810609674135 no 2760 0.192563436894633 3970 16488146
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.868925133354224 0.184687717057604 no 2761 0.192444040739852 3982 5379071
SGTC_3170 9103054 49.47 µM -0.869742833164087 0.184457620156619 no 2762 0.192220479370094 3956 16432970
SGTC_1652 st011932 78 µM -0.870880308946255 0.184137836496789 no 2763 0.191909754705078 3836 1551076
SGTC_2598 perillyl alcohol 100 µM -0.871658574345311 0.183919238212538 no 2764 0.19169733292292 3965 10819 An apoptosis inducer.
SGTC_2512 diallyl trisulfide 49.23 µM -0.87177447518983 0.183886697948547 no 2765 0.191665710968047 3951 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_139 0099-0334 718.624 µM -0.872390931088211 0.183713682353447 no 2766 0.19149757312673 3974 97690
SGTC_1275 0867-0008 21.1 µM -0.873447165048493 0.183417473722332 no 2767 0.191209696325095 3897 3422836
SGTC_2707 st078556 66.6 µM -0.873653962768409 0.1833595145589 no 2768 0.191153364633105 3904 17250899
SGTC_1140 3229-1848 2.98 µM -0.874461503260342 0.183133294693367 no 2769 0.190933488094931 3967 2849525
SGTC_3019 9081971 49.47 µM -0.875879953107931 0.182736359795736 no 2770 0.190547649380798 3959 16451803
SGTC_212 3807-4682 38.772 µM -0.876889521990194 0.182454172411931 no 2771 0.190273323972758 4010 3125501 YBL034C STU1
SGTC_1121 fusaric acid 630.51 nM -0.877081567728737 0.182400524009901 no 2772 0.190221167765116 3927 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1403 3909-7815 62.9 µM -0.878266385705348 0.182069760482832 no 2773 0.189899586563088 3872 6615483
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.878395085696842 0.182033854127747 no 2774 0.189864675175269 3983 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_273 hydroxyurea 18.1 mM -0.879403093758186 0.181752780416813 no 2775 0.189591377633529 4013 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3040 9091894 49.47 µM -0.880123713637568 0.181552008764934 no 2776 0.189396147033554 3823 25236966
SGTC_170 4197-0004 226 µM -0.880754896056804 0.181376269333292 no 2777 0.189225248553804 3984 218692
SGTC_2649 anisomycin 9.56 µM -0.881000115951071 0.181308021763522 no 2778 0.1891588786159 3928 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_305 1682-2595 20.8 µM -0.881322957897439 0.181218195592282 no 2779 0.189071521760796 3974 226033
SGTC_799 1310-0557 151 µM -0.88256736561134 0.180872217720448 no 2780 0.188735033661547 4023 5354492
SGTC_3006 9075424 71.4286 µM -0.883071180675547 0.180732261779376 no 2781 0.188598906998997 3898 7465181
SGTC_1497 4476-2978 41.3 µM -0.883306917513904 0.180666799226103 no 2782 0.188535233648901 3990 1528379
SGTC_448 monastrol 171 µM -0.884299958490947 0.180391201607063 no 2783 0.188267155341832 3869 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.884705623308804 0.180278693800415 no 2784 0.188157711000839 3906 4330530
SGTC_1038 k292-0204 154 µM -0.88551567324912 0.180054164892383 no 2785 0.187939285077922 3901 4454212
SGTC_3299 9121982 43.1275 µM -0.885912362074611 0.179944275113224 no 2786 0.18783237704459 4019 17594604 YPL160W CDC60
SGTC_627 1391-0720 175 µM -0.88631714358031 0.179832186944598 no 2787 0.187723326747481 3925 997839
SGTC_2041 5107442 45.335 µM -0.887460658248877 0.179515772971808 no 2788 0.187415469148514 3980 793005
SGTC_264 promethazine 12.5 mM -0.887757074355687 0.179433810882218 no 2789 0.187335718812926 3888 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2726 cimetidine 79.27 µM -0.88791849601512 0.179389186035825 no 2790 0.187292297367894 3946 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1835 st008666 49.2 µM -0.888059111187195 0.179350318807806 no 2791 0.187254477813079 3889 690455
SGTC_2592 piperlongumine 83.33 µM -0.892785024429022 0.178047116796289 no 2792 0.185986153785572 3984 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3111 9122088 49.47 µM -0.893943723496869 0.177728511439167 no 2793 0.185676001114155 3824 16876704
SGTC_1863 st057641 20.1 µM -0.894019933488782 0.177707568732014 no 2794 0.185655612995884 3969 3921635
SGTC_2356 9061756 188.97 µM -0.894121391025898 0.177679690349014 no 2795 0.185628472670333 3998 20104043
SGTC_2780 5215298 71.43 µM -0.896176892523895 0.177115476446472 no 2796 0.185079147493378 3995 2834131
SGTC_2837 9008476 45.46 µM -0.897604790513311 0.176724200168682 no 2797 0.184698142087476 3982 2992805
SGTC_1671 st016596 74.5 µM -0.898489148771857 0.176482140303771 no 2798 0.184462413867526 4012 2829167
SGTC_2713 st079149 53.4 µM -0.898496647365245 0.176480088742474 no 2799 0.184460415896502 4007 3103253
SGTC_1143 3454-2408 5.08 µM -0.898522935810339 0.176472896531845 no 2800 0.184453411548939 3881 X1143
SGTC_214 4373-3496 70 µM -0.898525344863882 0.17647223745229 no 2801 0.184452769684017 4031 3779166
SGTC_562 3772-2733 112 µM -0.90243654014852 0.175404249031436 no 2802 0.183412508927642 3990 2876874 YIL048W NEO1
SGTC_3062 9077494 49.47 µM -0.905153555396321 0.174664759703606 no 2803 0.182692021556283 3975 16459633
SGTC_595 3909-8003 73.7 µM -0.907414858406836 0.17405081302768 no 2804 0.182093727493815 4049 699517
SGTC_1706 st031321 9.9705 µM -0.908501134091985 0.17375637618638 no 2805 0.181806757425513 3999 6103185
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.913485997499897 0.172409286843926 no 2806 0.180493497347864 4072 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2304 7443016 91.4 µM -0.915327504862326 0.171913334901129 no 2807 0.18000986194437 3916 939854
SGTC_2067 5224629 34.075 µM -0.91671147331325 0.17154120680739 no 2808 0.179646926150547 4000 2835000
SGTC_1465 k213-0056 144 µM -0.918696008674613 0.171008494345804 no 2809 0.179127299042918 3863 24048857 YMR208W ERG12
SGTC_2233 sulbentine 40.3845 µM -0.919995848055611 0.170660150272544 no 2810 0.178787464462636 3967 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1953 st076800 12.1 µM -0.920286962628842 0.170582196752327 no 2811 0.178711410108134 4011 297591
SGTC_1054 3429-0080 167 µM -0.921487161273101 0.170261053048171 no 2812 0.178398070589665 4044 1162877
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.922820236015751 0.169904809311581 no 2813 0.178050446698304 3994 6857784
SGTC_2386 9075165 157.42 µM -0.926217686350829 0.168999055652899 no 2814 0.177166431486885 3966 16452277
SGTC_1299 1079-1439 3.74 µM -0.92787695518065 0.168557827113196 no 2815 0.176735699781248 3956 323161
SGTC_2842 9000675 19.48 µM -0.928179462303889 0.168477465077673 no 2816 0.176657242984511 4074 2989072
SGTC_2564 betulinic acid 100 µM -0.929872886352992 0.168028056322718 no 2817 0.176218451440757 4082 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2144 5628481 200 µM -0.931136937675029 0.167693099846694 no 2818 0.175891366812644 3993 2818399
SGTC_1412 3909-8563 178 µM -0.931680628813675 0.167549161406494 no 2819 0.17575080017998 4080 23767530
SGTC_1396 3511-0007 98.6 µM -0.932395858146807 0.167359930678253 no 2820 0.175565992252252 4023 X1396
SGTC_572 0960-0087 17.7 µM -0.934169523515844 0.166891260337713 no 2821 0.175108226921879 3995 6796365
SGTC_1111 tnp00062 510.699 nM -0.934458177493713 0.166815067074879 no 2822 0.175033799909684 4057 676306
SGTC_1910 st062352 60.4 µM -0.936205210743309 0.166354398250484 no 2823 0.174583770424064 3944 2245730
SGTC_1015 4130-4525 82 µM -0.936974080600743 0.166151918335017 no 2824 0.174385945364883 4007 1363237
SGTC_106 0092-0003 11.579 µM -0.938971498956473 0.165626647681003 no 2825 0.173872688837682 3915 1072148
SGTC_203 k066-0004 30.888 µM -0.940146202052202 0.165318232432507 no 2826 0.173571286285644 4086 6795412
SGTC_513 4245-1575 41.7 µM -0.941345317798295 0.165003791243168 no 2827 0.17326396311919 3932 719745
SGTC_2784 7567673 72.73 µM -0.941388379711493 0.164992506430676 no 2828 0.173252933165698 3997 3471247
SGTC_3337 9144342 33.5465 µM -0.942479150685396 0.164706825454489 no 2829 0.172973690299063 4023 17682949
SGTC_285 1486-1325 46 µM -0.942944250799426 0.164585109813373 no 2830 0.172854709578033 4063 22310230
SGTC_2848 9016370 25.97 µM -0.94367154159069 0.164394896336459 no 2831 0.172668760482486 3998 7894410
SGTC_402 epigallocatechin gallate 10 µM -0.947088672771564 0.163503098628272 no 2832 0.171796798100019 3971 65064 An antioxidant.
SGTC_2533 agelasine 13.65 µM -0.949588826576171 0.162852606319367 no 2833 0.171160609042562 4092 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2641 levomentholum 100 µM -0.950682171014642 0.162568668575142 no 2834 0.170882870743869 4017 16666
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.952349195455786 0.162136368459644 no 2835 0.170459957968697 4095 165506
SGTC_1668 st014914 51.6 µM -0.954560931383833 0.161563967905806 no 2836 0.169899891123368 4038 2839556
SGTC_3004 9076122 71.4286 µM -0.95549097330781 0.161323665612588 no 2837 0.169664734013481 4071 44782551
SGTC_1961 st076550 68.7 µM -0.956722448890664 0.161005838403978 no 2838 0.169353682097683 4068 1579337
SGTC_2882 9058044 58.44 µM -0.957953734805479 0.160688468994787 no 2839 0.169043044263924 4066 18076804
SGTC_286 k060-0067 22.9 µM -0.958461213350435 0.16055778312048 no 2840 0.168915120419899 4038 5985051
SGTC_663 1486-0733 13.9 µM -0.958890936687689 0.16044717506936 no 2841 0.168806845542191 4051 722445 YPR165W RHO1
SGTC_832 4083-0019 164 µM -0.959925734817104 0.160181028957963 no 2842 0.168546296546044 4108 1990758
SGTC_2972 9093619 59.92 µM -0.96009191974582 0.16013831374258 no 2843 0.168504477403547 4026 25236256
SGTC_360 0957-0399 1.01 µM -0.961705176747129 0.159724038545186 no 2844 0.168098860614249 4061 6752301 YPR165W RHO1
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.962435946407011 0.159536612034086 no 2845 0.167915332128754 4095 688788
SGTC_2047 4141938 200 µM -0.963245198187797 0.15932922461279 no 2846 0.16771224388674 4043 3807862
SGTC_3231 9132313 49.47 µM -0.964747025462436 0.158944818478463 no 2847 0.167335767609294 4019 4905967
SGTC_2801 7907800 81.82 µM -0.965399639273359 0.158777965720274 no 2848 0.167172341044572 4070 6620925
SGTC_2970 9090938 41.86 µM -0.965591995341428 0.158728808259867 no 2849 0.167124191168917 4131 17217104
SGTC_1031 k035-0009 16 µM -0.966996273420054 0.158370240995438 no 2850 0.166772948302625 4118 5180959
SGTC_2526 patulin 37.61 µM -0.967552160938717 0.158228448038864 no 2851 0.166634039484998 4096 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2393 9031399 185.94 µM -0.967575837104851 0.158222410693276 no 2852 0.166628124787738 4111 1526623 YDL150W RPC53
SGTC_1862 st057513 3.81 µM -0.96923712542113 0.157799165006323 no 2853 0.166213445849648 4035 5393163
SGTC_490 phenamil 164 µM -0.970536406404437 0.157468666441805 no 2854 0.165889593534655 4029 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.971618646280329 0.157193724228763 no 2855 0.165620151356637 4092 23665772 A membrane-active detergent.
SGTC_843 0310-0051 143 µM -0.975055596936003 0.156322663824164 no 2856 0.164766341272884 4083 2065037
SGTC_955 1216-0110 33 µM -0.975116629576551 0.156307224503586 no 2857 0.164751205306147 4035 3619719
SGTC_883 0850-0245 24.6 µM -0.976406764958685 0.155981096236458 no 2858 0.164431465212703 4131 6823229 YPR165W RHO1
SGTC_1667 st014849 34.6 µM -0.976693076680296 0.155908781472621 no 2859 0.164360561858192 4101 5348460
SGTC_857 0438-0306 1.35 µM -0.978259360116925 0.155513570939035 no 2860 0.163973032178868 4123 4686136
SGTC_2647 atorvastatin 60.16 µM -0.978543681418015 0.155441900855477 no 2861 0.163902749060057 4031 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_229 benomyl 22.8748 µM -0.980707841343471 0.154897086198383 no 2862 0.163368417960903 4084 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1390 3413-2614 145 µM -0.981624133571165 0.154666795480364 no 2863 0.163142526763104 4101 3421432
SGTC_3252 9135871 49.47 µM -0.98305671603142 0.154307199712744 no 2864 0.162789762819052 4101 17682838
SGTC_2044 5102272 200 µM -0.983427188008576 0.154214296745806 no 2865 0.162698617339611 4074 592666
SGTC_202 3594-0513 34.79 µM -0.984014500124977 0.15406709277181 no 2866 0.162554191737627 4078 708429
SGTC_2101 5377231 179.231 µM -0.98435772020243 0.153981111103163 no 2867 0.162469829305665 4114 2844213
SGTC_19 0279-0214 38.434 µM -0.986866550990113 0.153353576591441 no 2868 0.161854031962928 4138 3566274 YBR002C RER2
SGTC_2020 4017018 200 µM -0.988808866096172 0.152868910011003 no 2869 0.161378332778961 4155 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_708 3448-5400 146 µM -0.989166441363811 0.152779794956638 no 2870 0.161290857252567 4019 3462195
SGTC_251 melphalan 456.522 µM -0.990138773456002 0.152537644213352 no 2871 0.161053146946935 4102 460612 A DNA alkylator.
SGTC_1578 josamycin 24.2 µM -0.990758228280543 0.152383507318501 no 2872 0.160901825384359 4088 5282165 A P450 substrate.
SGTC_2256 7954252 200 µM -0.991717566079287 0.152145002556241 no 2873 0.160667659812969 4105 2972920
SGTC_3124 9127567 49.47 µM -0.992658367731629 0.151911347010174 no 2874 0.160438235010242 4084 17592030
SGTC_2217 6934799 96.0675 µM -0.992822063958807 0.151870716115509 no 2875 0.160398337762778 4059 675606
SGTC_2059 5238311 157 µM -0.994623599279644 0.151424035636746 no 2876 0.159959682656936 4072 703021
SGTC_888 0916-0002 6.97 µM -0.996815423316428 0.150881764424272 no 2877 0.15942705523331 4133 2802138 YIL048W NEO1
SGTC_9 0092-0002 10.449 µM -1.00501744557185 0.148864013410611 no 2878 0.157444224755902 4064 759368
SGTC_2993 9054257 71.4286 µM -1.00575497922846 0.148683463036905 no 2879 0.157266724425158 4038 6470217 YGL055W OLE1
SGTC_3132 9126706 49.47 µM -1.00584804004246 0.148660691884942 no 2880 0.157244337069459 4184 850858
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.00930270868984 0.14781701482838 no 2881 0.156414740739362 4103 229346 A bile salt which induces apoptosis.
SGTC_1472 k841-0093 193 µM -1.01140277134895 0.147305720743098 no 2882 0.155911847649792 4203 X1472
SGTC_2899 9053889 58.44 µM -1.01203769559922 0.147151371838174 no 2883 0.155760015102253 4079 6470052
SGTC_2170 morpholine 200 µM -1.0125762923688 0.147020524992949 no 2884 0.15563129427562 4149 121171 Reacts with secondary amines.
SGTC_77 0828-0286 12.516 µM -1.0145042672184 0.146552781933029 no 2885 0.155171097140674 4026 745345
SGTC_782 0083-0095 30.5 µM -1.01725785774463 0.145886471203569 no 2886 0.154515389319415 4088 3591729 An indicator and reagent.
SGTC_1686 st019653 115.5 µM -1.01779098080296 0.145757702296006 no 2887 0.154388649569398 4084 97252
SGTC_129 0088-0017 176.636 µM -1.02044550843929 0.145117673368398 no 2888 0.153758610090108 3969 182446
SGTC_1401 3807-4679 7.6 µM -1.02072953803905 0.145049303632026 no 2889 0.153691297958779 4056 3291456
SGTC_1224 0823-0416 294 µM -1.02204658045042 0.144732557239478 no 2890 0.153379427286368 4183 3598164
SGTC_2746 daunorubicin 9.88 µM -1.02367114652274 0.144342494101533 no 2891 0.152995314059308 4048 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_127 0180-0333 59.125 µM -1.02457251539558 0.144126378655265 no 2892 0.152782469254595 3990 771601
SGTC_2619 obliquin 87.91 µM -1.0246505710402 0.144107674023056 no 2893 0.152764046823111 4063 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1297 1068-0111 14.1 µM -1.02569026106869 0.143858687099253 no 2894 0.152518803180438 4085 767057
SGTC_575 k072-0246 11.9 µM -1.02712072326516 0.143516591911045 no 2895 0.152181810827157 4193 6796779
SGTC_2634 4'-methoxyflavone 100 µM -1.02738485269208 0.143453485440382 no 2896 0.152119640579101 4126 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1821 st053465 65.6 µM -1.02761819203663 0.143397751001811 no 2897 0.152064731671536 4127 675086
SGTC_1187 1391-0724 117 µM -1.02949713844176 0.142949486799749 no 2898 0.151623061883985 4156 6997986
SGTC_339 3091-4833 71.4 µM -1.03232749377471 0.142276032265126 no 2899 0.150959362754792 3994 3240077
SGTC_1388 3346-4487 254 µM -1.03309009038914 0.142094947807489 no 2900 0.150780870189078 4179 3345614
SGTC_721 1187-1332 279 µM -1.0338419143735 0.141916574167461 no 2901 0.15060503665602 4061 25730
SGTC_1252 0493-0875 34.8 µM -1.03433021658519 0.141800803504774 no 2902 0.150490907703393 4120 3960963
SGTC_460 trequinsin 123 µM -1.03493649494525 0.141657151123945 no 2903 0.150349284844927 4180 5537 A vasodilator.
SGTC_2834 9001755 58.44 µM -1.03655739510966 0.141273577172321 no 2904 0.149971088860475 4048 2989575
SGTC_2760 etidronate 98.04 µM -1.03835714984059 0.14084850423858 no 2905 0.149551905535085 4082 3305 A chelator and antioxidant.
SGTC_247 mechlorethamine 29.705 µM -1.03936328533087 0.140611249840023 no 2906 0.149317906213049 4035 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_140 0062-0056 502.533 µM -1.04368327342465 0.139595647623052 no 2907 0.14831597554355 4054 3758964
SGTC_356 1634-0012 32.5 µM -1.04496478383659 0.139295334289145 no 2908 0.148019622989904 4151 735457
SGTC_3089 9117425 49.47 µM -1.04870272789432 0.138421884753332 no 2909 0.147157479180964 4147 9401657
SGTC_261 5-fluorouridine 15.376 µM -1.05081536751346 0.137929876376773 no 2910 0.146671698180704 4163 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_531 3788-1495 174 µM -1.05104481431237 0.137876512880437 no 2911 0.146619003968264 4115 2896655
SGTC_1487 3970-0795 2.82 µM -1.05308673473518 0.137402234488439 no 2912 0.146150620978176 4184 3765103
SGTC_1812 st052057 4.327 µM -1.05334073038625 0.137343316724412 no 2913 0.146092428911793 4162 3645418
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -1.0542420907468 0.137134373123815 no 2914 0.145886046991168 4117 688803
SGTC_2274 7947094 46.08 µM -1.05603112811339 0.136720301372994 no 2915 0.145476996818623 4104 2971028
SGTC_560 2332-1943 155 µM -1.05986620160437 0.135835558180453 no 2916 0.144602736894046 4118 21177716
SGTC_2718 lomofungin 53.02 µM -1.06018604051114 0.135761949563838 no 2917 0.144529985269862 4143 5351222 A RNA synthesis inhibitor.
SGTC_2772 vinpocetine 57.06 µM -1.0602199878089 0.135754138442204 no 2918 0.144522264952228 4190 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_928 2764-0428 58.7 µM -1.06217940315732 0.135303807279313 no 2919 0.144077124210268 4183 662578
SGTC_2884 9058502 51.95 µM -1.06255926986791 0.135216621399897 no 2920 0.143990933052563 4198 6471554
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.06383180881355 0.134924832713788 no 2921 0.143702449391074 4114 16623 A steroid.
SGTC_910 3454-3003 490 µM -1.06636181211672 0.134345995650667 no 2922 0.143130058701395 4101 820824
SGTC_109 0132-0036 33.701 µM -1.0668886052208 0.134225685968902 no 2923 0.143011070459564 3970 67274 A color developer.
SGTC_1344 1488-0097 29.1 µM -1.06762543041435 0.134057533061342 no 2924 0.142844753830353 4191 747966
SGTC_432 NS 1619 61.3 µM -1.06928457706841 0.133679424679817 no 2925 0.142470729024555 4167 4552 A K+/calcium channel activator.
SGTC_1615 st002656 86.5 µM -1.07018976453415 0.133473447961215 no 2926 0.142266950298055 4156 1584458
SGTC_3338 9144300 39.5675 µM -1.07128024775245 0.133225596951264 no 2927 0.142021719219481 4160 4901274
SGTC_1392 3455-1037 33.9 µM -1.07304378812816 0.132825440396434 no 2928 0.141625734970782 4171 981132
SGTC_1060 3448-7350 82 µM -1.07408629270806 0.132589280273433 no 2929 0.14139200373913 4128 570178
SGTC_767 0929-0023 86 µM -1.07443354142508 0.132510681763887 no 2930 0.141314208085025 4169 1204563
SGTC_2915 7971052 15.16 µM -1.07599388364464 0.13215790012657 no 2931 0.140964995917793 4083 5741558
SGTC_290 2043-6722 48.1 µM -1.07636183016623 0.132074804626837 no 2932 0.140882733061604 4198 773758 YLR208W SEC13
SGTC_2340 7987427 183.45 µM -1.07718127751746 0.131889873559663 no 2933 0.140699643922569 4198 2239331
SGTC_3281 9140613 49.47 µM -1.08060572097019 0.131118986063085 no 2934 0.139936268307308 4181 16013766
SGTC_1195 1502-0147 41.1 µM -1.08312070830977 0.130554815252236 no 2935 0.139377424202115 4140 817940
SGTC_2373 9071805 200 µM -1.08425581098319 0.130300735590032 no 2936 0.139125696050676 4199 10149009
SGTC_1394 3474-0001 65.7 µM -1.08465968963125 0.130210414572896 no 2937 0.139036203837431 4184 5017666 YIL048W NEO1
SGTC_2995 9067767 71.4286 µM -1.08606248709441 0.129897037880876 no 2938 0.138725673734922 4191 11673567
SGTC_1379 2144-0755 36.5 µM -1.08699109628601 0.129689879510766 no 2939 0.138520372320686 4234 5392327
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.08769397390235 0.129533230588597 no 2940 0.13836511445795 4159 442882
SGTC_343 4130-2827 29.8 µM -1.08866572073468 0.129316875288406 no 2941 0.138150661780954 4199 1118244
SGTC_789 1309-1135 70.6 µM -1.08886514756084 0.129272504745294 no 2942 0.138106678755925 4159 3092424
SGTC_2367 9070478 135.38 µM -1.08965213483717 0.129097510665586 no 2943 0.1379332041268 4130 572802
SGTC_3122 9126309 49.47 µM -1.09047150373958 0.12891549081522 no 2944 0.137752749657219 4234 17591206
SGTC_3184 9108758 49.47 µM -1.09113887366581 0.128767368577703 no 2945 0.137605889915303 4206 902885
SGTC_2859 9028643 45.46 µM -1.09180019221845 0.128620705948767 no 2946 0.137460467277145 4044 17151580
SGTC_1272 0839-0021 27 µM -1.09259274681077 0.128445091462966 no 2947 0.1372863243648 4199 5027250
SGTC_823 0417-1665 178 µM -1.09736837625617 0.127390429393868 no 2948 0.136240195843834 4178 3429856
SGTC_1488 4013-0813 75.9 µM -1.0982208231162 0.127202808187784 no 2949 0.136054037829146 4119 2910057
SGTC_1555 citronellol 128 µM -1.0986102347905 0.127117163754028 no 2950 0.135969055766741 4144 8842 A terpine precursor.
SGTC_312 4092-0653 6.84 µM -1.10062000299143 0.12667578759936 no 2951 0.135531038001864 4122 1148278
SGTC_571 k831-0106 44.2 µM -1.10066509236323 0.126665897532482 no 2952 0.135521222126422 4054 4783639
SGTC_2922 7999257 32.47 µM -1.10264802850019 0.126231484856294 no 2953 0.135090022205603 4163 2988377
SGTC_316 k060-0003 58.6 µM -1.10371492656049 0.125998183785556 no 2954 0.134858409292773 4234 6152314
SGTC_2741 miltefosine 3.04 µM -1.10445177995106 0.12583722997802 no 2955 0.134698604920898 4212 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_353 1988-1175 58.3 µM -1.10477779117247 0.125766063833143 no 2956 0.13462794303313 4041 2788357
SGTC_2055 5235184 200 µM -1.10760829373671 0.125149363340458 no 2957 0.134015510015614 4246 2836034
SGTC_2497 7-hydroxyflavone 100 µM -1.11241397028277 0.124107161128152 no 2958 0.132980100343875 4224 5281894
SGTC_274 sirtinol 40.1 µM -1.11397750502825 0.123769391867987 no 2959 0.132644418601582 4260 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_741 4582-0002 126 µM -1.11522797890708 0.123499716486468 no 2960 0.132376369626167 4209 2912688
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.11541419526047 0.123459592572042 no 2961 0.132336484635017 4252 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2019 4016004 108 µM -1.11668768940483 0.123185438381889 no 2962 0.132063941654919 4238 45595336
SGTC_2928 9011484 9.79 µM -1.11690421929247 0.123138866916005 no 2963 0.132017640196844 4222 2994751
SGTC_495 decylubiquinone 155 µM -1.11717054685559 0.123081601841443 no 2964 0.131960705656015 4263 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1155 4088-0394 48.2 µM -1.11795071081744 0.122913960413273 no 2965 0.131794022507052 4174 2326248
SGTC_2146 5545642 200 µM -1.12015950898486 0.122440202950169 no 2966 0.131322897635227 4172 825326
SGTC_797 k781-0471 270 µM -1.1204101263061 0.122386529966931 no 2967 0.131269515849834 4184 23738129
SGTC_754 3474-0146 171 µM -1.12454610807915 0.121503139512722 no 2968 0.130390710788756 4197 24762078
SGTC_2623 humulene 100 µM -1.12454989183872 0.121502333409707 no 2969 0.130389908690788 4227 6187145 An anti-inflammatory.
SGTC_679 0422-0091 41.4 µM -1.12652345406214 0.121082392289473 no 2970 0.129972009374619 4236 627384 YHR062C RPP1
SGTC_2880 9042983 58.44 µM -1.12659935335424 0.121066262600113 no 2971 0.129955956330019 4202 6464714
SGTC_2022 5136654 200 µM -1.12872302297154 0.120615565049275 no 2972 0.129507346980667 4253 1713771
SGTC_1873 rapamycin 2 nM -1.12962049610182 0.120425453609793 no 2973 0.129318085372861 4176 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1901 st060216 58.6 µM -1.13100077196967 0.120133482279589 no 2974 0.129027383256858 4182 688792
SGTC_1444 4112-3581 28 µM -1.13282505861454 0.119748354692625 no 2975 0.128643863018581 4271 2877249
SGTC_507 nimesulide 162 µM -1.13466073139045 0.119361703000924 no 2976 0.128258748261759 4296 4495 A COX2 inhibitor.
SGTC_3283 9109332 35.8195 µM -1.13584574345294 0.119112569770645 no 2977 0.128010564422225 4073 17027281
SGTC_1192 1488-0095 21.4 µM -1.14031359775346 0.118176564056838 no 2978 0.127077837384356 4282 915875
SGTC_2171 5739187 198.077 µM -1.14107816290282 0.118016911962714 no 2979 0.126918698840402 4166 2262761
SGTC_2142 5622915 118.518 µM -1.14178429973495 0.117869596110779 no 2980 0.126771844990026 4244 5322196
SGTC_1707 st032323 6.317 µM -1.14198370269264 0.117828019786017 no 2981 0.126730396990356 4090 3132057 YMR211W DML1
SGTC_1254 0550-0035 264 µM -1.1421615066973 0.117790955683365 no 2982 0.126693446519282 4260 15121435
SGTC_2145 5634607 200 µM -1.14270788402159 0.117677112326177 no 2983 0.126579947662872 4204 308662
SGTC_2198 6589944 200 µM -1.14423274168738 0.117359804509466 no 2984 0.126263563978158 4229 5290268
SGTC_1021 4476-0760 85.3 µM -1.14736024344245 0.116710899250407 no 2985 0.125616382597266 4238 746768
SGTC_1041 0206-0046 107 µM -1.14933587011195 0.11630230248945 no 2986 0.125208756299881 4239 50494
SGTC_3236 9132701 49.47 µM -1.15161701419952 0.115831782745809 no 2987 0.124739243339052 4234 24282524
SGTC_643 k048-0106 28.4 µM -1.15191684088769 0.115770039707759 no 2988 0.124677623582528 4256 6763920
SGTC_390 dec-rvkr-cmk 16.7 µM -1.15617718183181 0.11489523639332 no 2989 0.123804345592902 4291 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1025 k007-0731 70 µM -1.15890499703979 0.114337591500053 no 2990 0.123247455910841 4213 6256118
SGTC_2725 haloperidol 53.21 µM -1.16173000917938 0.113762110859179 no 2991 0.12267257599974 4189 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1149 3909-7961 23.3 µM -1.1621673315249 0.113673209179602 no 2992 0.122583750864073 4295 735261
SGTC_1727 st034309 9.9045 µM -1.16248132562312 0.113609409005918 no 2993 0.122520002932597 4319 870305
SGTC_2035 5154463 94.595 µM -1.16478962680384 0.113141170996974 no 2994 0.12205207939657 4269 2769623
SGTC_2465 5809242 33.21 µM -1.17046418819942 0.111995946040198 no 2995 0.120907108830716 4304 2731748
SGTC_2931 9014674 55.67 µM -1.17164762776823 0.111758155570576 no 2996 0.120669278889663 4219 2996810
SGTC_867 0518-0118 155 µM -1.17188170301886 0.111711165253483 no 2997 0.12062227699562 4229 6848158
SGTC_626 0214-0009 33 µM -1.17401631828345 0.111283295921595 no 2998 0.120194244741501 4314 3437874
SGTC_1824 st053723 68.6 µM -1.17461337904452 0.11116382933122 no 2999 0.120074714109163 4286 675225
SGTC_2065 5221596 34.26 µM -1.17471859378278 0.111142786311322 no 3000 0.120053658968018 4240 788581
SGTC_419 nsc-638432 893 µM -1.17596349000015 0.110894022722864 no 3001 0.119804732970162 4217 368090
SGTC_803 4488-1585 147 µM -1.17701841184351 0.110683533521083 no 3002 0.119594078761665 4248 747204
SGTC_2821 7996764 71.43 µM -1.17935398119515 0.110218534987718 no 3003 0.11912862573964 4310 2987135
SGTC_869 0564-0080 44.1 µM -1.18007304975779 0.110075655036747 no 3004 0.118985581178591 4281 6843321
SGTC_3028 9087778 49.47 µM -1.18262899066043 0.109568861639845 no 3005 0.118478108866384 4249 17217395
SGTC_1947 st076332 61.6 µM -1.1861618264991 0.108871130535181 no 3006 0.117779199120163 4151 24208416
SGTC_630 4356-0227 183 µM -1.19071939644885 0.107975741928416 no 3007 0.116881880383795 4216 779312
SGTC_115 0527-0192 112.043 µM -1.19447261585494 0.107242368654897 no 3008 0.116146573194399 4267 4233931
SGTC_3099 9120367 49.47 µM -1.19478195784158 0.107182084299984 no 3009 0.116086115629697 4322 24824940
SGTC_205 1486-1330 71.903 µM -1.19482787538055 0.107173138004595 no 3010 0.11607714344476 4328 4118834
SGTC_2213 7173844 200 µM -1.19512209723644 0.107115826377959 no 3011 0.116019664830425 4272 892728
SGTC_1799 st045822 46.1415 µM -1.195906112451 0.106963215578283 no 3012 0.115866599792301 4262 3674992
SGTC_2891 9063876 19.48 µM -1.19843257760233 0.106472499146715 no 3013 0.115374328095642 4301 6472478
SGTC_2936 9038235 15.59 µM -1.19967593939871 0.106231598113121 no 3014 0.115132610507433 4224 4749415
SGTC_1729 st035615 45.989 µM -1.20002909714463 0.106163245736056 no 3015 0.115064020060626 4311 17385451
SGTC_3334 9142812 21.919 µM -1.20178104310178 0.105824632779823 no 3016 0.114724185995658 4292 45283678
SGTC_2900 5328528 85.29 µM -1.20196585499174 0.105788958241633 no 3017 0.114688378756988 4297 795359
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.20211920533609 0.10575936337656 no 3018 0.114658673219343 4306 61125 An anti-inflammatory.
SGTC_1959 st077091 55.8 µM -1.20317856094638 0.105555083312827 no 3019 0.114453614698273 4291 821356 YKL052C ASK1
SGTC_1962 st076595 64.5 µM -1.20342888861273 0.105506853268207 no 3020 0.114405197152401 4272 279619
SGTC_2309 7664088 163.95 µM -1.20893142403572 0.104450715357061 no 3021 0.113344596153116 4296 704922
SGTC_695 3505-6186 243 µM -1.21096095955881 0.104063113379096 no 3022 0.11295518377021 4288 1819379
SGTC_831 k061-1017 217 µM -1.21422170796886 0.103442559137212 no 3023 0.112331536569208 4331 1240153
SGTC_796 1234-0020 70.7 µM -1.21786330621723 0.102752705133527 no 3024 0.111637961150078 4243 46495034
SGTC_586 0957-0265 8.15 µM -1.21900429321293 0.102537249234465 no 3025 0.11142128150269 4171 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2715 st079500 56.4 µM -1.22334215077498 0.101721117042049 no 3026 0.110600246544284 4276 28246688
SGTC_830 4076-0286 57.8 µM -1.223464884729 0.101698094655174 no 3027 0.110577079693281 4373 6866659
SGTC_2086 5274770 176.623 µM -1.2282297215885 0.100807238813357 no 3028 0.109680372199254 4341 689278
SGTC_1484 3473-2379 286 µM -1.23274763062132 0.0999678182815748 no 3029 0.108834967644803 4435 671917
SGTC_3171 9103192 49.47 µM -1.23806093071931 0.0989871607351329 no 3030 0.107846734520177 4401 13018434
SGTC_986 1493-0483 84 µM -1.24105202939647 0.0984382093066946 no 3031 0.107293264502205 4263 40079
SGTC_3030 9087619 49.47 µM -1.24535944585237 0.0976515976177465 no 3032 0.106499826655626 4329 25236973
SGTC_1468 k284-1086 134 µM -1.24702880473487 0.0973479851629811 no 3033 0.106193467979093 4324 15996457
SGTC_2638 epoxomicin 18 µM -1.24905147907173 0.0969810425231087 no 3034 0.105823122866423 4295 9915668 A protesome inhibitor.
SGTC_1925 st057770 10.1 µM -1.25025238646549 0.0967636613378611 no 3035 0.105603682781089 4315 5989122
SGTC_354 2783-3500 4.88 µM -1.25410172981007 0.0960692878213459 no 3036 0.104902515859546 4344 6740761
SGTC_1137 ixabepilone 100 µM -1.25440695885152 0.0960143854853197 no 3037 0.104847062242678 4289 154225 A novel microtubule stabilizer.
SGTC_1914 st062367 72.6 µM -1.25442730416971 0.0960107267407473 no 3038 0.104843366686302 4332 978205
SGTC_1023 4482-3888 16 µM -1.2589928874898 0.0951922782242223 no 3039 0.10401645045032 4359 3303168
SGTC_907 3448-6986 75.5 µM -1.2601463815979 0.0949863126634188 no 3040 0.103808280537054 4360 590582
SGTC_2031 5180455 200 µM -1.2615141526219 0.0947425119012627 no 3041 0.103561832113729 4317 29949
SGTC_1436 4092-1007 8.32 µM -1.26542837490248 0.0940473631556793 no 3042 0.10285890446557 4329 2881121
SGTC_2436 5633522 8.09 µM -1.26602524362001 0.0939416934285562 no 3043 0.102752022352138 4319 5724242
SGTC_1171 0368-0077 21.4 µM -1.27270680640653 0.0927647636230019 no 3044 0.101561050732097 4306 3239779
SGTC_1325 1431-0015 227 µM -1.2740816104139 0.0925239560592857 no 3045 0.101317247476482 4350 1103340
SGTC_651 3253-0966 34.4 µM -1.27582538965959 0.0922191853295916 no 3046 0.101008625130059 4353 781462
SGTC_976 1348-1067 47.6 µM -1.27705900229951 0.0920040286963642 no 3047 0.100790708749021 4372 5310671 YGL099W LSG1
SGTC_403 arphamenine a 50 µM -1.27934449920908 0.0916063936640559 no 3048 0.100387884446695 4345 5487158 An arginine aminopeptidase inhibitor.
SGTC_993 3909-8757 62.7 µM -1.28142954719614 0.0912447452141854 no 3049 0.100021415690939 4284 4288324 YLR208W SEC13
SGTC_2748 diazoxide 86.69 µM -1.28253416046785 0.0910535811961716 no 3050 0.0998276647867365 4427 3019 A potassium channel activatior.
SGTC_693 4161-2696 114 µM -1.28268585964099 0.0910273514021649 no 3051 0.0998010779380259 4393 805759
SGTC_714 4296-0578 26.1 µM -1.28308675652223 0.0909580606477896 no 3052 0.0997308415115851 4406 1589775
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.2838511513327 0.0908260515910703 no 3053 0.0995970209743409 4353 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2582 agaric acid 100 µM -1.29414512466314 0.0890621339592714 no 3054 0.0978076486562327 3982 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_596 1155-0152 116 µM -1.29485513217315 0.0889414176164078 no 3055 0.0976851044616285 4374 280313
SGTC_1632 st005650 90 µM -1.29804168087419 0.088401136527533 no 3056 0.0971365063054027 4387 2759605
SGTC_3084 9116877 49.47 µM -1.2995195517967 0.0881513944021434 no 3057 0.0968828440320577 4315 27241325
SGTC_511 blebbistatin 171 µM -1.30094347851446 0.0879112660641036 no 3058 0.0966389011380278 4420 3476986 A myosin inhibitor.
SGTC_272 doxorubicin 8.13 µM -1.30302639574307 0.0875608859977494 no 3059 0.096282875085991 4394 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1723 st034307 2.5525 µM -1.30486171119971 0.0872530210799042 no 3060 0.0959699705414606 4373 867466
SGTC_485 niflumic acid 177 µM -1.30570612521164 0.0871116466483257 no 3061 0.0958262570975775 4406 4488 A COX2 inhibitor.
SGTC_2957 9076800 11.52 µM -1.30680250476824 0.0869283427020766 no 3062 0.0956398971412159 4336 16459615
SGTC_3112 9123419 49.47 µM -1.3107421494089 0.0862720503855098 no 3063 0.0949724466405368 4427 17015854
SGTC_1231 0242-0792 125 µM -1.31082265870706 0.0862586773544573 no 3064 0.0949588427081854 4375 3707635
SGTC_1373 2887-0003 58.5 µM -1.31609419875671 0.0853864164592973 no 3065 0.0940712139301512 4326 776948
SGTC_467 ro 31-8220 72.8 µM -1.31731887712433 0.0851847228004072 no 3066 0.0938658801213249 4328 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3329 9141233 27.5565 µM -1.31776940498017 0.0851106147501803 no 3067 0.0937904263551973 4344 4909101 YNL103W MET4
SGTC_1264 0783-0040 158 µM -1.32015722121518 0.0847186454903924 no 3068 0.0933912656722782 4293 2855798
SGTC_1112 tnp00069 1.16933 µM -1.32042259607173 0.0846751669050762 no 3069 0.0933469817303335 4377 145826
SGTC_3165 9101544 49.47 µM -1.32054681083548 0.0846548215107107 no 3070 0.093326258950412 4379 5002184
SGTC_569 4130-2812 160 µM -1.32506384528845 0.0839174555759321 no 3071 0.0925749882055217 4236 743552
SGTC_1669 st015249 58.4 µM -1.32695891412205 0.0836095425665644 no 3072 0.0922611370233691 4494 722793
SGTC_805 3852-0218 479 µM -1.32940835818652 0.0832128127280952 no 3073 0.0918566409061619 4358 6615355
SGTC_921 1561-0023 372 µM -1.33318166236416 0.0826044329010096 no 3074 0.0912360978081894 4373 24050882
SGTC_762 1165-0429 115 µM -1.33352109456826 0.0825498699048565 no 3075 0.0911804288462711 4382 5967793
SGTC_889 0919-1524 82.7 µM -1.3405473507206 0.0814264989524369 no 3076 0.0900337304635199 4407 3905452
SGTC_2225 6654152 15.4 µM -1.34272627072766 0.0810804819527652 no 3077 0.08968031243166 4318 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2739 tacrine 100.86 µM -1.34302426080581 0.0810332468975979 no 3078 0.0896320591098489 4441 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3280 9140961 49.47 µM -1.34471777496964 0.0807651986169753 no 3079 0.0893581961204554 4428 4901226
SGTC_880 0833-0487 87.2 µM -1.34574758590159 0.0806025285033004 no 3080 0.089191967092577 4394 76075
SGTC_2929 9013348 24.6 µM -1.35400831991589 0.0793065964116453 no 3081 0.0878668616866678 4373 2995952
SGTC_1471 k673-0312 37 µM -1.35515225840506 0.079128387412312 no 3082 0.0876845258879967 4366 24099884
SGTC_2359 9039622 200 µM -1.36183620980469 0.078093182015747 no 3083 0.0866247906640637 4367 6463596
SGTC_1664 st014217 9.02 µM -1.36203576050366 0.0780624344554496 no 3084 0.0865932998782676 4471 3982782
SGTC_2873 9040596 71.43 µM -1.36417683745934 0.0777331065608273 no 3085 0.0862559581418232 4382 6463863
SGTC_1836 st055642 81 µM -1.36655444436556 0.0773686340371832 no 3086 0.0858825023024838 4407 8571
SGTC_363 0455-0021 3.06 µM -1.37361754284434 0.0762935595395386 no 3087 0.0847802239047571 4366 4597466
SGTC_16 erodoxin 22.806 µM -1.37628484380418 0.0758905399187808 no 3088 0.0843667316834695 4452 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2413 inermin 26.06 µM -1.37742200457901 0.0757192127491038 no 3089 0.0841909067637455 4466 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1670 st016595 4.04 µM -1.38238078353449 0.0749755541642423 no 3090 0.0834274066485404 4441 597879
SGTC_1232 0279-0259 161 µM -1.38252092115549 0.0749546192263249 no 3091 0.0834059056100697 4408 1560000
SGTC_1283 0922-0125 16.4 µM -1.38525139261768 0.0745476076472181 no 3092 0.0829878055117558 4425 3360884
SGTC_2664 lyso-paf C-16 73.48 µM -1.38541374511805 0.0745234601779148 no 3093 0.0829629952287592 4381 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3237 9133362 49.47 µM -1.38733924718076 0.0742375261316135 no 3094 0.0826691704088184 4386 43845137
SGTC_3277 9138724 49.47 µM -1.38781740078701 0.0741666511018086 no 3095 0.0825963273894644 4381 15943418
SGTC_533 1222-0222 6.71 µM -1.38858363986641 0.0740531819623975 no 3096 0.0824796975234024 4444 3982874
SGTC_2956 9076196 2.52 µM -1.38873923749684 0.0740301563689163 no 3097 0.0824560290351197 4416 16423868
SGTC_1199 1638-0010 4.46 µM -1.39366180276471 0.07330452746091 no 3098 0.081709878001855 4424 3111136
SGTC_256 clotrimazole 625 nM -1.39397975046435 0.0732578469290119 no 3099 0.0816618597975769 4365 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1991 st073000 8.92 µM -1.39427637512978 0.0732143175161465 no 3100 0.0816170810998412 4460 4301969 YIL048W NEO1
SGTC_1778 st046819 58.9 µM -1.39448659191999 0.0731834803677371 no 3101 0.0815853578152708 4473 671715
SGTC_2224 6650123 117.647 µM -1.39597011879683 0.0729661411126557 no 3102 0.0813617467943632 4455 2908370
SGTC_3274 9138298 49.47 µM -1.39972863106164 0.0724177240857458 no 3103 0.0807972983359094 4409 17015756
SGTC_119 0121-0043 24.815 µM -1.39991864488591 0.0723900826291436 no 3104 0.0807688410225288 4452 1092378
SGTC_773 4358-1457 44.6 µM -1.40389988969337 0.0718127852191689 no 3105 0.0801743312688306 4430 1186886
SGTC_1425 4048-4433 7.33 µM -1.40456219628437 0.0717170914585225 no 3106 0.0800757523286228 4502 23734946
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.40856387322158 0.0711409864792931 no 3107 0.0794820838060429 4441 5282362
SGTC_3138 9097216 49.47 µM -1.40965558496184 0.0709844358491639 no 3108 0.0793207027221546 4377 25237486
SGTC_1995 st072814 61.1 µM -1.41060127848852 0.070849038118966 no 3109 0.0791811072220444 4427 5769371
SGTC_322 k048-0136 19.3 µM -1.4117761202046 0.0706811090209776 no 3110 0.0790079459343456 4490 6823282
SGTC_2923 7992654 58.14 µM -1.41360506757932 0.0704202925704183 no 3111 0.0787389462721531 4432 2985126
SGTC_1419 3993-2473 62.6 µM -1.41645994129914 0.0700146540088232 no 3112 0.0783204423747228 4509 704026
SGTC_1294 1000-1494 117 µM -1.41786763131925 0.0698153033849013 no 3113 0.078114707091866 4444 712797 YDL207W GLE1
SGTC_633 0437-0093 97.7 µM -1.42112789167663 0.0693552779819741 no 3114 0.0776397913967755 4372 2831118
SGTC_1287 0971-0001 34.6 µM -1.42425988299278 0.0689155537052111 no 3115 0.0771856279167851 4426 4665869
SGTC_3250 9135583 49.47 µM -1.42784130540976 0.0684153676641073 no 3116 0.0766687704238325 4473 7699353
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.43274229150097 0.0677354345444441 no 3117 0.0759657493235581 4448 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1335 1486-0900 202 µM -1.43454816041924 0.0674862194227361 no 3118 0.0757079479435945 4452 X1335
SGTC_259 usnic acid 108.925 µM -1.43513542480401 0.0674053281104868 no 3119 0.0756242552973227 4498 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2296 7971656 126.45 µM -1.43570912579344 0.0673263774397053 no 3120 0.0755425636906251 4458 666570
SGTC_521 r062-0005 13.8 µM -1.43701923659366 0.0671463527178567 no 3121 0.0753562638345145 4383 2832033
SGTC_524 r073-0010 27.8 µM -1.43788254844675 0.0670279270631924 no 3122 0.0752336910576009 4395 2772106
SGTC_2702 st077768 96.8 µM -1.43988772880787 0.0667534878552173 no 3123 0.0749495826971138 4426 6484119
SGTC_1493 4348-0038 111 µM -1.44116169674627 0.0665795783193499 no 3124 0.0747695033654666 4434 800424
SGTC_904 1141-0088 396 µM -1.44172585510329 0.0665026771121652 no 3125 0.0746898633726936 4462 1378119
SGTC_2719 novobiocin 32.65 µM -1.44545860548201 0.065995592165321 no 3126 0.0741645560645001 4501 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2790 5423970 71.43 µM -1.44575869087828 0.0659549567655211 no 3127 0.0741224481221452 4482 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1732 st034308 51.822 µM -1.44595169088229 0.0659288323433828 no 3128 0.0740953760388105 4346 830119
SGTC_2088 5278280 127.392 µM -1.44694698783872 0.0657942365320268 no 3129 0.0739558857746975 4505 791502
SGTC_3246 9135460 32.98 µM -1.44957681876723 0.0654396245609684 no 3130 0.0735882821135107 4430 41446951
SGTC_1076 itraconazole 331 nM -1.45046550898967 0.065320127371517 no 3131 0.0734643753303968 4467 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2343 7990716 14.84 µM -1.45189145641482 0.0651287420232776 no 3132 0.0732658942470277 4467 6456862
SGTC_2089 5281248 129.67 µM -1.45269101876663 0.0650216183139316 no 3133 0.0731547808699996 4452 2737878
SGTC_1234 0326-0494 15.5 µM -1.45570381392459 0.0646191984017119 no 3134 0.0727372575594984 4528 1547813
SGTC_2485 5633444 17.78 µM -1.45943434566406 0.0641235939779906 no 3135 0.0722227993288344 4445 5724239
SGTC_2653 dihydrofissinolide 100 µM -1.45980716691591 0.0640742272029514 no 3136 0.072171539151293 4527 6857746
SGTC_1016 4226-1401 38 µM -1.46078647100033 0.0639446943184071 no 3137 0.0720370248781018 4477 2901613
SGTC_3290 9121031 71.43 µM -1.46650383206393 0.0631925178331817 no 3138 0.0712555389971058 4491 17014854
SGTC_1316 1272-0050 65.9 µM -1.46724801612561 0.0630951217630368 no 3139 0.0711542996583708 4464 7340392
SGTC_126 0417-1624 672.48 µM -1.46740888781187 0.0630740828449107 no 3140 0.0711324290830115 4519 41912 YDL195W SEC31
SGTC_370 0180-0345 38.7 µM -1.46760051943109 0.0630490282513022 no 3141 0.0711063834186211 4310 3989527
SGTC_2406 ethylparaben 405.7 µM -1.46882142283599 0.0628895850087908 no 3142 0.0709406159242549 4429 8434 A possible steroid mimic.
SGTC_3118 9124250 49.47 µM -1.46957846668274 0.0627908771596691 no 3143 0.0708379779042837 4439 1504786
SGTC_2840 9008771 71.43 µM -1.47048570872496 0.0626727446571705 no 3144 0.0707151267356128 4422 2992978
SGTC_1503 4585-0012 61.3 µM -1.47292349968759 0.0623561765242668 no 3145 0.0703858323632607 4492 2922052
SGTC_1564 D-Arginine 115 µM -1.47441814016678 0.062162702106432 no 3146 0.0701845216185431 4474 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_818 4072-2707 53.5 µM -1.47884916390082 0.0615918776260351 no 3147 0.0695903163147759 4406 882871
SGTC_1761 st044296 37 µM -1.48183688787414 0.0612093017160077 no 3148 0.0691918506488022 4494 1826700
SGTC_1026 k007-1105 30.6 µM -1.48265336393952 0.0611050762718572 no 3149 0.0690832655928492 4453 7066794
SGTC_392 N-ethylmaleimide 8.33 µM -1.48916670479202 0.0602785898679299 no 3150 0.0682217380052335 4441 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2865 9030313 51.95 µM -1.49053402906058 0.0601062046176466 no 3151 0.0680419379329059 4478 42562754
SGTC_900 1112-0045 141 µM -1.49256505983376 0.0598508554452865 no 3152 0.067775537551937 4383 56211 YIL048W NEO1
SGTC_2053 5265679 138 µM -1.49380438156557 0.0596954609860958 no 3153 0.0676133779967825 4412 764595
SGTC_2452 5863136 48.41 µM -1.49503527286614 0.0595414366749902 no 3154 0.0674526184009907 4436 2184096
SGTC_1242 0402-0103 60.1 µM -1.4975900208337 0.0592227493168778 no 3155 0.0671199005321655 4422 432868
SGTC_747 3448-8087 38.7 µM -1.4983387774722 0.0591296009520763 no 3156 0.0670226270086031 4534 5168703
SGTC_995 3931-2021 34.6 µM -1.50829488458595 0.0579019142686674 no 3157 0.0657395359368659 4514 730143
SGTC_320 4092-0846 5.34 µM -1.50895661515394 0.0578210318113576 no 3158 0.0656549351016079 4473 1359356
SGTC_1504 k297-0033 30 µM -1.50996841930456 0.0576975320915249 no 3159 0.0655257413432915 4403 4388117
SGTC_567 1080-0542 68.4 µM -1.51191687855934 0.0574602896779452 no 3160 0.0652775048139332 4385 5950415
SGTC_1837 st055472 66.5 µM -1.51457128819418 0.0571383270954327 no 3161 0.0649405039254698 4551 676091
SGTC_380 3970-0968 6 µM -1.5151221486429 0.0570716895748869 no 3162 0.0648707368150715 4400 2891601
SGTC_2688 kanamycin b 96.69 µM -1.51583914421006 0.0569850463670591 no 3163 0.0647800156794463 4481 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1197 1601-0112 267 µM -1.52132384465203 0.0563256858589106 no 3164 0.0640892946767851 4476 7350313
SGTC_2686 alizarin 95.37 µM -1.52137520905711 0.0563195394721851 no 3165 0.0640828532201523 4474 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_204 PMA1.184 62.41 µM -1.52143556963569 0.0563123172577079 no 3166 0.064075284223568 4473 2252213 YGL008C PMA1
SGTC_2581 avocatin a 64 µM -1.5215908039831 0.0562937466380361 no 3167 0.0640558215944142 4443 6710728 A skin care supplement.
SGTC_1215 3852-0577 11.2 µM -1.52311826216693 0.056111274827404 no 3168 0.063864560353346 4527 2884876
SGTC_1931 st074438 57.1 µM -1.5239902281677 0.0560073181458022 no 3169 0.0637555761255249 4512 2787313
SGTC_2178 5812956 200 µM -1.5293164310632 0.0553756170143887 no 3170 0.0630930091113664 4482 5403383
SGTC_768 0384-0033 77.3 µM -1.53088979974547 0.0551900919045533 no 3171 0.062898315306997 4464 3965305 YMR134W ERG29
SGTC_2764 methyldopa 94.69 µM -1.53095716348605 0.0551821596256035 no 3172 0.0628899899575272 4469 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2996 9066192 71.4286 µM -1.53134520208457 0.0551364844707367 no 3173 0.0628420497614832 4493 6472854
SGTC_2769 toremifene 3.73 µM -1.5325585764429 0.0549938535766491 no 3174 0.0626923272380701 4511 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2166 5933061 31.504 µM -1.53306368411204 0.0549345647090373 no 3175 0.0626300822441375 4543 2877375
SGTC_2432 5630864 12.22 µM -1.53505698958062 0.0547010860205695 no 3176 0.0623849149743265 4523 5714970
SGTC_2449 5812982 45.77 µM -1.53868612289818 0.0542780156203784 no 3177 0.0619404708834308 4447 776185
SGTC_145 3737-0113 38.366 µM -1.53902010205201 0.0542392120636257 no 3178 0.0618996943971098 4497 6849351
SGTC_1415 3966-0071 78.1 µM -1.53998063103131 0.0541277347986343 no 3179 0.0617825373892172 4431 2893185
SGTC_927 2425-1185 123 µM -1.54431996963357 0.0536263772874576 no 3180 0.0612554185663829 4476 730375
SGTC_2168 5727979 200 µM -1.5445358603356 0.0536015301418759 no 3181 0.061229285407907 4435 695210
SGTC_896 0964-0007 44.5 µM -1.54563263176911 0.0534754420963917 no 3182 0.0610966578404883 4474 6756758
SGTC_2659 sanguinarine 24.21 µM -1.5467893837589 0.0533427132756927 no 3183 0.0609570204978441 4481 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1902 st060212 70.5 µM -1.54902845285616 0.0530865384295716 no 3184 0.0606874402192849 4511 688944
SGTC_157 1348-1695 65.819 µM -1.55313340184826 0.0526194202669444 no 3185 0.0601956338757686 4444 5380510
SGTC_3214 9129694 49.47 µM -1.55588634204803 0.0523079839759116 no 3186 0.0598675608490064 4526 17158655
SGTC_18 0111-0177 500 nM -1.55830971891996 0.0520350436694267 no 3187 0.0595799230848282 4595 721752
SGTC_2539 epi(13)torulosol 80 µM -1.56113389452024 0.0517183911094201 no 3188 0.0592460811393503 4493 6708597
SGTC_1747 st037496 66.6 µM -1.56292131372763 0.0515187746605921 no 3189 0.0590355518857714 4483 723305
SGTC_1259 0671-0132 43 µM -1.56478522323515 0.0513112689366292 no 3190 0.0588166388399364 4466 X1259
SGTC_1317 1273-0028 910 nM -1.56514315816085 0.0512714968812997 no 3191 0.0587746729890454 4546 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1859 st055998 20 µM -1.56911108470798 0.0508322404800897 no 3192 0.0583110286853234 4455 676301
SGTC_933 2914-0560 114 µM -1.56950562908553 0.0507887280042387 no 3193 0.058265084433652 4541 463887
SGTC_144 4161-2749 112.381 µM -1.57167751155898 0.0505497318705374 no 3194 0.0580126800787577 4530 797501 YMR168C CEP3
SGTC_1891 st059073 26.2 µM -1.57175723062698 0.0505409765790016 no 3195 0.0580034319380731 4597 688754
SGTC_1 0258-0098 57.368 µM -1.58373748831497 0.0492388962982493 no 3196 0.0566267349955891 4455 6790032 YDR047W HEM12
SGTC_1277 0873-0036 22 µM -1.58887819531166 0.0486884530984592 no 3197 0.0560439474238625 4598 5965735
SGTC_1324 1418-0026 34.4 µM -1.59011179206805 0.0485570997496148 no 3198 0.0559048042028695 4553 1372513
SGTC_3232 9132874 49.47 µM -1.5938763998951 0.0481579954140387 no 3199 0.0554818606420906 4517 3784940
SGTC_2964 9083345 53.42 µM -1.59491866765399 0.0480479647299575 no 3200 0.0553652122814926 4511 17741579
SGTC_2205 7238770 200 µM -1.5982101641909 0.0477018066933499 no 3201 0.0549981062157671 4585 279867
SGTC_878 0828-0289 13.7 µM -1.60326678916535 0.0471739085938148 no 3202 0.0544378827026825 4508 745350 YLR208W SEC13
SGTC_614 0462-0418 107 µM -1.60693401380896 0.0467939978704418 no 3203 0.0540344219855152 4315 5188303
SGTC_2326 6164455 177.58 µM -1.6070260181566 0.0467844982182928 no 3204 0.0540243303701788 4481 2888790
SGTC_1326 1431-2094 10.8 µM -1.60868223870336 0.0466137542319016 no 3205 0.0538429207253145 4562 616278
SGTC_347 4534-1311 26.2 µM -1.60919613987325 0.0465608766211434 no 3206 0.0537867301076579 4572 2862016
SGTC_675 1309-0189 238 µM -1.60980047353387 0.0464987556052633 no 3207 0.0537207109112103 4552 4246530
SGTC_2424 5537928 59.2 µM -1.6150435471451 0.0459625944570337 no 3208 0.0531506323933321 4556 5382802
SGTC_318 1488-0629 67.2 µM -1.62663195610639 0.0447951724421856 no 3209 0.051907644051165 4597 3662576
SGTC_2693 st077581 40.7 µM -1.63554140636146 0.0439139624583075 no 3210 0.0509678009980942 4510 25238761
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.64836619500361 0.0426701008534649 no 3211 0.0496387743129675 4622 279621
SGTC_677 0929-0063 136 µM -1.64988608814635 0.0425245949567303 no 3212 0.0494831183155705 4598 1539583
SGTC_452 diindolylmethane 8 µM -1.66996883247136 0.0406394092571479 no 3213 0.047462765145632 4569 3071 Inhibits expression of several cancer promoting factors.
SGTC_1868 st057644 42.7 µM -1.67867546967678 0.0398434649871119 no 3214 0.0466076546109223 4611 688665
SGTC_3057 9095946 49.47 µM -1.68381411752873 0.0393796768360061 no 3215 0.0461087989942798 4626 24540043
SGTC_1994 st072947 40.9 µM -1.68802233101041 0.0390031447624039 no 3216 0.0457034711700585 4633 5286565 YDL195W SEC31
SGTC_2508 celastrol 40.54 µM -1.68980639726111 0.0388444017972841 no 3217 0.0455324997691668 4523 122724 Celastrol is a natural product and antioxidant.
SGTC_263 alizarin 107.927 µM -1.69747859458946 0.0381677305143001 no 3218 0.0448031073142362 4619 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1792 st045773 43.6 µM -1.69902476881989 0.0380325319884811 no 3219 0.0446572584093742 4572 2919270
SGTC_93 0109-0045 59.227 µM -1.70078362316929 0.037879211811771 no 3220 0.0444918127976352 4676 88733
SGTC_1481 3346-2004 36 µM -1.70746975884413 0.0373009747272747 no 3221 0.0438673870128598 4661 2770522
SGTC_1986 st071812 45 µM -1.71205119280033 0.0369089375059493 no 3222 0.0434436173644868 4550 11838594
SGTC_2332 7982454 138.89 µM -1.71443342496671 0.0367064229278963 no 3223 0.0432245771080924 4492 2981748
SGTC_2261 9010538 184.68 µM -1.72455129879995 0.0358564015775025 no 3224 0.0423041832852683 4569 6457250
SGTC_2302 7771753 200 µM -1.72568836255302 0.0357618910220863 no 3225 0.0422017463932203 4572 2203047
SGTC_375 3970-0961 9.27 µM -1.7286891102933 0.0355134545135901 no 3226 0.0419323756849379 4583 2898222
SGTC_1191 1487-1166 10.6 µM -1.72977692513336 0.0354237428420262 no 3227 0.0418350693222708 4606 3955771
SGTC_2543 pimpinellin 60.67 µM -1.73858120111378 0.0347044760658953 no 3228 0.0410542277881356 4472 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1290 0986-0249 10.2 µM -1.74808455174484 0.0339416027461134 no 3229 0.040224693790224 4490 53329
SGTC_2949 9072542 2.23 µM -1.7514067962836 0.0336781879218497 no 3230 0.0399379315754462 4572 16457352
SGTC_3234 9132280 49.47 µM -1.75150146693436 0.0336707063779802 no 3231 0.0399297844128886 4626 17612295
SGTC_493 zm226600 134 µM -1.75241804587128 0.0335983425335685 no 3232 0.039850975331408 4608 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2314 7727897 200 µM -1.75930621782485 0.0330586079163331 no 3233 0.0392627555347635 4584 900724
SGTC_922 1866-0035 480 µM -1.77051961159377 0.032195257957445 no 3234 0.0383203101561876 4561 3156169
SGTC_1746 st038117 42 µM -1.77212893590952 0.0320728926540279 no 3235 0.0381865783234829 4634 2898218
SGTC_2795 7780010 54.55 µM -1.77611910271669 0.0317711551003133 no 3236 0.037856644140584 4581 953673
SGTC_246 cycloheximide 667 µM -1.77770098745695 0.0316521834970722 no 3237 0.037726488713889 4572 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2833 9001315 45.46 µM -1.78190188932824 0.0313380248538641 no 3238 0.0373826161987504 4555 2989378
SGTC_738 1315-0003 72.4 µM -1.78505962757048 0.0311035790294304 no 3239 0.0371258227991073 4618 6251474
SGTC_2264 7948757 110.76 µM -1.7859682100085 0.0310363909134147 no 3240 0.0370522027651287 4581 2971411
SGTC_2325 6158266 200 µM -1.79381122638514 0.0304613914919042 no 3241 0.0364216522353652 4593 3623240
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.79751192737742 0.0301931602270457 no 3242 0.0361271931616206 4617 641818 YHR062C RPP1
SGTC_2193 5925765 200 µM -1.80062495586514 0.0299690430512358 no 3243 0.0358810064932429 4652 877370
SGTC_1153 4055-0057 267 µM -1.81191556475104 0.0291677404093251 no 3244 0.0349996220120993 4654 882706
SGTC_1769 st044406 64.4 µM -1.81575076669732 0.0288996360501364 no 3245 0.0347043063383059 4620 670903
SGTC_3317 9138495 8.753 µM -1.82464828191632 0.0282855261630762 no 3246 0.0340270612215857 4562 17020139
SGTC_2620 irigenin 100 µM -1.83438771441009 0.0276257978617642 no 3247 0.0332982309946293 4605 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_396 dithiazanine 1.25 µM -1.83792123430709 0.0273896375263912 no 3248 0.0330370063185932 4615 10578 An antihelmenthic.
SGTC_143 4032-1194 15.74 µM -1.85297470264828 0.0264023331107732 no 3249 0.0319429923221795 4652 1806963
SGTC_2888 9058547 12.99 µM -1.85539991496493 0.0262460881142602 no 3250 0.0317695697675019 4580 16476514
SGTC_1562 morin hydrate 59.1 µM -1.85733044197589 0.0261222666248813 no 3251 0.0316320779624063 4645 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_657 3534-0529 86.7 µM -1.8605385126901 0.0259175856757447 no 3252 0.0314046874550604 4662 1049549
SGTC_1737 st035557 69.7 µM -1.86121940163149 0.0258743167364528 no 3253 0.0313565998006568 4507 5716916
SGTC_3185 9108267 49.47 µM -1.86291019985193 0.0257671317069786 no 3254 0.0312374507643074 4639 4910486
SGTC_2499 avocadenofuran 51.48 µM -1.86539900808538 0.0256100345788955 no 3255 0.0310627481527892 4614 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1893 st059353 36.1 µM -1.87386577705522 0.0250815920378557 no 3256 0.0304744637399032 4642 3112488
SGTC_17 0960-0276 49.807 µM -1.89661562071347 0.0237067856875007 no 3257 0.0289393437140751 4657 6821114
SGTC_262 fenpropimorph 62.5 µM -1.90325650414007 0.0233176221549905 no 3258 0.0285035417098344 4693 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3182 9108849 49.47 µM -1.91067004430251 0.0228895453856407 no 3259 0.0280234983663552 4646 17133045
SGTC_2838 9002687 71.43 µM -1.91717040957848 0.0225196638510523 no 3260 0.0276081429874414 4650 6457060
SGTC_2079 5212404 121 µM -1.92057531375072 0.0223279389186731 no 3261 0.0273926349279858 4627 758462
SGTC_2268 7933382 153.85 µM -1.93653346782793 0.0214476120684461 no 3262 0.0264011988194893 4684 935025 YOR257W CDC31
SGTC_1361 1608-0041 5.61 µM -1.94089898801137 0.0212119641516515 no 3263 0.0261352653976071 4675 X1361
SGTC_1857 st056007 79.3 µM -1.94160350985683 0.021174140507361 no 3264 0.0260925588325157 4660 619834
SGTC_1850 st056238 17 µM -1.94996022042065 0.0207298290626729 no 3265 0.0255904302659255 4671 5393177
SGTC_2502 avocadyne acetate 18.59 µM -1.9556591133646 0.0204313781859704 no 3266 0.0252526621234534 4644 3952079
SGTC_2068 5226020 147 µM -1.96070184678064 0.0201703347204315 no 3267 0.024956906761628 4681 1810509
SGTC_2823 7987624 58.44 µM -1.96319747421755 0.020042195106138 no 3268 0.0248116163722166 4610 2239440
SGTC_2694 st077685 81.9 µM -1.96967072874799 0.019713036165392 no 3269 0.0244380598911861 4607 2838096
SGTC_943 3253-1379 105 µM -1.99333764469656 0.0185483839694511 no 3270 0.0231122434381072 4649 668464
SGTC_3010 9080089 71.4286 µM -1.99445676223364 0.0184947942367996 no 3271 0.0230510803217779 4697 17027233
SGTC_2195 6536160 144.242 µM -1.99573698433132 0.0184336516366329 no 3272 0.0229812795714694 4699 3834386
SGTC_3157 9099274 49.47 µM -2.00494337637087 0.0179990103458838 no 3273 0.0224845503973115 4684 17217662
SGTC_2405 ticlatone 3.52 µM -2.0344399814501 0.0166648257000444 no 3274 0.0209536270932166 4522 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_457 grayanotoxin iii 135 µM -2.03771375922935 0.0165221013822024 no 3275 0.0207892836766692 4502 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3055 9094636 49.47 µM -2.043794792896 0.0162597669462876 no 3276 0.0204869119006367 4689 25236176
SGTC_2455 5377712 9.75 µM -2.04719245636014 0.0161147521540869 no 3277 0.0203195959120025 4696 2243908
SGTC_1070 indatraline 8.81 µM -2.06450051454012 0.0153931153346014 no 3278 0.0194851425818261 4725 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1765 st044815 90.4 µM -2.06620674133112 0.0153235025751028 no 3279 0.019404481297244 4705 645695
SGTC_2658 polymyxin b sulfate 77.05 µM -2.08063920353324 0.0147454091036165 no 3280 0.018733471353798 4728 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_944 3370-0224 231 µM -2.08371048787145 0.0146248389325485 no 3281 0.0185932548283753 4677 4580514
SGTC_2194 5927483 104.545 µM -2.08576573576245 0.0145446301614901 no 3282 0.0184999242957777 4725 760979
SGTC_2540 epiandrosterone 100 µM -2.09960788817341 0.0140142207549447 no 3283 0.0178816741531631 4712 441302 A steroid.
SGTC_923 1900-2434 73.3 µM -2.11845052589762 0.0133190498517905 no 3284 0.0170684653392177 4672 5910570
SGTC_3072 9116419 49.47 µM -2.15167353202311 0.012165740819356 no 3285 0.0157115380938884 4705 17170162
SGTC_926 2268-1401 59.4 µM -2.16056162782878 0.0118722757994877 no 3286 0.015364609118033 4687 2931578
SGTC_1459 k035-0031 35.7 µM -2.1728999800907 0.0114750812683728 no 3287 0.0148939229912053 4556 3877128 YMR208W ERG12
SGTC_2614 arthonioic acid 13.39 µM -2.17736079197803 0.011334347434735 no 3288 0.0147268293254068 4615 6710684
SGTC_613 3914-0030 117 µM -2.17850007777229 0.0112986455518267 no 3289 0.0146844132245029 4536 1145395
SGTC_1874 staurosporine 7.6 µM -2.1958573314909 0.0107666861480396 no 3290 0.0140510782928899 4721 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3294 9122953 26.2835 µM -2.20349471067822 0.0105396130474615 no 3291 0.013779949683379 4701 16459826
SGTC_1303 1160-0052 261 µM -2.20655362751805 0.0104498429121116 no 3292 0.0136726298645136 4680 3562476
SGTC_849 0386-0493 241 µM -2.21611388626379 0.0101735599101185 no 3293 0.0133418517307805 4733 726119
SGTC_2354 9060492 162 µM -2.23676566127545 0.00959840566227144 no 3294 0.0126508299791288 4722 6471895
SGTC_2561 acetosyringone 100 µM -2.24923554070921 0.00926505501790009 no 3295 0.0122487572035428 4702 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_678 1218-2179 85.9 µM -2.26712049418043 0.00880464399862467 no 3296 0.0116914329728133 4757 6820081 YOR116C RPO31
SGTC_497 capsazepine 133 µM -2.27189478087365 0.00868518289590776 no 3297 0.0115464331082186 4697 2733484 A calcium channel blocker.
SGTC_244 nsc-207895 1.295 µM -2.27658707764301 0.00856916067963066 no 3298 0.0114054476361581 4671 42640
SGTC_1018 4259-0013 28.1 µM -2.27830777895102 0.00852695643711474 no 3299 0.0113541232597532 4747 6801262
SGTC_2306 7482397 179.52 µM -2.27993668416371 0.00848717187195656 no 3300 0.0113057219789231 4710 891448
SGTC_1457 k015-0032 57.3 µM -2.28361235906234 0.00839799479185796 no 3301 0.0111971613952808 4739 4302660
SGTC_1133 3473-0247 50 µM -2.32310136041859 0.0074906173430235 no 3302 0.0100868539607337 4708 711311
SGTC_2251 lansoprazole 556 µM -2.32578567414612 0.00743219652755881 no 3303 0.0100149936334947 4731 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_381 3461-2219 42.7 µM -2.32627345462723 0.00742162379348279 no 3304 0.010001983608494 4736 2883159
SGTC_681 1642-0006 26.6 µM -2.3279454398604 0.00738548370260772 no 3305 0.00995750049019409 4746 4446530
SGTC_2459 5811157 9.22 µM -2.35031523853979 0.00691666778269221 no 3306 0.00937875872405214 4729 2870684 YBR192W RIM2
SGTC_939 1165-0479 45.3 µM -2.36004156162773 0.00672116141024889 no 3307 0.00913644386513172 4724 1377347
SGTC_3254 9136651 49.47 µM -2.43388102699407 0.00538949037863752 no 3308 0.00746895204866671 4731 16454030
SGTC_410 α-linolenic acid 100 µM -2.43556828038087 0.00536201848038131 no 3309 0.00743420907855495 4760 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1768 st044301 37.178 µM -2.44650396884881 0.00518696251837777 no 3310 0.00721246046136773 4762 3931349
SGTC_2819 7996655 46.38 µM -2.4536580426393 0.00507521147773556 no 3311 0.007070569213716 4742 6456960
SGTC_2283 7944793 200 µM -2.45582780769152 0.00504174470670906 no 3312 0.00702802451711021 4736 2970533
SGTC_1860 st056228 74.6 µM -2.46152210357279 0.00495484784222493 no 3313 0.00691744363208665 4754 688679
SGTC_1848 st056003 16.4 µM -2.47457443144193 0.00476068044876035 no 3314 0.00666975108226637 4745 146492
SGTC_954 1189-0853 2.85 µM -2.47942821671064 0.0046902244370725 no 3315 0.00657966074849119 4719 2828194
SGTC_646 4092-0839 27.3 µM -2.55410215953539 0.00371753389369576 no 3316 0.00532310076189219 4765 877796
SGTC_2266 7929956 200 µM -2.5996340612295 0.00321730760774479 no 3317 0.00466616092400383 4751 2967153
SGTC_269 exalamide 29 µM -2.6045507375114 0.0031670878964248 no 3318 0.00459973994996121 4775 3316 A derivative of salicylamide.
SGTC_413 propylparaben 100 µM -2.63363047280765 0.00288422515502492 no 3319 0.0042238685961051 4769 7175 A pharmaceutical preservative.
SGTC_2980 9014342 25.29 µM -2.66019043084151 0.00264599732447085 no 3320 0.00390482411076636 4752 2996599
SGTC_2824 7998404 51.95 µM -2.66039767964969 0.00264421045670023 no 3321 0.00390242187639857 4754 837851
SGTC_2011 4012611 177 µM -2.70046734509273 0.00231853023050454 no 3322 0.00346210670184792 4754 2049887
SGTC_1173 0443-0020 122 µM -2.7447152634649 0.00200144173978823 no 3323 0.00302817099613869 4780 5331295
SGTC_1575 cyproterone acetate 48 µM -2.74737105227257 0.00198372542933184 no 3324 0.00300375633376374 4763 9880 An androgen receptor antagonist and liver toxin.
SGTC_957 1187-1561 14.1 µM -2.75096066763366 0.00196000602674658 no 3325 0.00297103887446653 4739 1538454
SGTC_1240 0356-0016 42.1 µM -2.87552885019011 0.00128051578905782 no 3326 0.00201675641398118 4763 4305613
SGTC_150 3970-0969 77.2 µM -2.88002016964259 0.00126063416575821 no 3327 0.00198824865417152 4775 6615640
SGTC_427 1354-0053 47.3 µM -2.88663932019591 0.00123184767937685 no 3328 0.00194690156870246 4778 6813657
SGTC_1926 methyl fluorone black 53.6 µM -2.90412782500256 0.00115866072728166 no 3329 0.00184138883832699 4600 72721 Reacts with homocysteine.
SGTC_3153 9100258 49.47 µM -2.94995856843218 0.000985353097577166 yes 3330 0.0015890827280624 4754 25236848
SGTC_905 2-aminofluorene 215 µM -2.9937213550876 0.000842398841802079 yes 3331 0.0013779875662599 4793 1539 An established DNA mutagen. YPR165W RHO1
SGTC_141 0443-0274 32.331 µM -3.05098211708717 0.000684131918793802 yes 3332 0.00114047079752663 4764 1627241
SGTC_385 1494-0393 12.4 µM -3.08071929892134 0.00061322305328146 yes 3333 0.00103250612244419 4792 3090647
SGTC_429 1112-0049 25.5 µM -3.114192314056 0.000541561281107234 yes 3334 0.000922246115976954 4774 2836170
SGTC_1682 st012968 530 nM -3.16310103153176 0.000450686576264672 yes 3335 0.000780490743131163 4781 24207270
SGTC_471 1-acyl-paf 4 µM -3.17751222534817 0.000426738580044233 yes 3336 0.000742722135999446 4793 16759367
SGTC_3217 9129673 49.47 µM -3.2374036794256 0.000339314598587828 yes 3337 0.000603113256196264 4777 17248312
SGTC_1078 idebenone 36.1 µM -3.30612579990249 0.000259627999185482 yes 3338 0.00047297803589022 4804 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1066 ketoconazole 628 nM -3.32344864101668 0.000242498048942939 yes 3339 0.000444558966141923 4803 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_3159 9100096 49.47 µM -3.37608381709684 0.000196696743483202 yes 3340 0.000367627582173104 4784 25236875
SGTC_1896 st058441 89 µM -3.48811481193641 0.000124761598668071 yes 3341 0.000243219575727906 4803 688759
SGTC_750 4073-0104 132 µM -3.50692076105842 0.000115432526292234 yes 3342 0.000226662058859351 4708 22330957
SGTC_1675 st018485 24.5 µM -3.56894315597671 8.90966748674263e-05 yes 3343 0.000179212087679123 4795 3323024
SGTC_2238 6671620 73.2395 µM -4.04853914677743 1.04807767271581e-05 yes 3344 2.57691573492243e-05 4783 729941
SGTC_454 lyso-paf C-16 6.67 µM -4.1954478585944 5.18077868611646e-06 yes 3345 1.36166466574339e-05 4805 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3150 9097574 49.47 µM -4.69984520191875 3.86656266802834e-07 yes 3346 1.30179384941192e-06 4809 17217476
SGTC_3351 9150312 21.596 µM -4.82481518205091 1.9485470247587e-07 yes 3347 7.00665755745219e-07 4810 4904905
SGTC_428 3448-4153 16.5 µM -6.08420910606079 7.59415111059331e-11 yes 3348 5.85338685097169e-10 4809 3834874
SGTC_2244 6635614 200 µM -6.68287687757867 9.92800594961903e-13 yes 3349 1.17148209180098e-11 4809 836499
SGTC_1107 amlodipine 47 µM -7.33153144519587 5.80361014919629e-15 yes 3350 1.13768709501211e-13 4793 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2240 6690706 185.951 µM -8.43886936067939 3.07447103695703e-19 yes 3351 1.6021098748831e-17 4795 805876