SGTCid condition conc unit MEC3|YLR288C.score MEC3|YLR288C.strain.pval MEC3|YLR288C.strain.significant MEC3|YLR288C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 7.73186642621104 3.35248405936014e-18 yes 1 5.29905579489139e-15 3 16725076
SGTC_6 0844-0013 19.835 µM 6.24609919930141 1.69465725194665e-12 yes 2 2.10414981169026e-10 11 1584900
SGTC_2182 6325192 200 µM 6.0462225183632 8.06576382455633e-12 yes 3 7.41406339370349e-10 3 736248
SGTC_2017 5132927 60.65 µM 5.71714000376049 9.4622921626905e-11 yes 4 5.41659296165073e-09 6 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 4.25969503132699 1.05718941165121e-06 yes 5 1.02353007083779e-05 26 23665772 A membrane-active detergent.
SGTC_1360 1598-0022 39.8 µM 4.18220104031598 1.6149650862858e-06 yes 6 1.44350254161481e-05 24 761525
SGTC_2592 piperlongumine 83.33 µM 4.0406617333744 3.43688359274726e-06 yes 7 2.66502959866239e-05 36 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2038 4100038 30.985 µM 3.861408893286 8.64168459670172e-06 yes 8 5.63675252891084e-05 55 3596803
SGTC_1673 st016611 27.3 µM 3.76688841536636 1.38365945576618e-05 yes 9 8.26474172042889e-05 50 5226799
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 3.72364630437115 1.71005598474047e-05 yes 10 9.81829899839264e-05 14 61125 An anti-inflammatory.
SGTC_2493 resveratrol 26.09 µM 3.62365349987526 2.76694709846247e-05 yes 11 0.000145235342229644 13 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_669 0108-0021 26.2 µM 3.51624848689408 4.57856100131309e-05 yes 12 0.000218845567520612 111 17201
SGTC_2492 derrusnin 100 µM 3.47042858920011 5.65236115216938e-05 yes 13 0.000259814247341051 10 1715307 Part of coumarin class of compounds.
SGTC_1889 st059080 5.18 µM 3.39385981568366 7.99324191213067e-05 yes 14 0.000344574799497016 40 176925 Isolated from Daphnopsis sellowiana.
SGTC_1258 0671-0043 57.1 µM 3.27689476447272 0.000133905054560039 yes 15 0.000524777398917442 55 4298767
SGTC_2680 butyl paraben 22.24 µM 3.24292621027279 0.000155080356757944 yes 16 0.000591544238653426 25 7184 An antifungal and steroid mimetic.
SGTC_1385 3091-4834 14.1 µM 3.18098564241386 0.000201976082860283 yes 17 0.00073387451785227 43 4072814
SGTC_1350 1495-0454 146 µM 3.09963636334987 0.000283803542834761 yes 18 0.000968791818145978 67 1069057
SGTC_2114 5491910 81.25 µM 3.05765685186437 0.00033722919945474 yes 19 0.00111537430942707 46 2849228
SGTC_2055 5235184 200 µM 3.05751522045953 0.000337424315295757 yes 20 0.00111590153501142 74 2836034
SGTC_2553 4-methylesculetin 85.09 µM 3.04905291207712 0.000349274558751817 yes 21 0.00114782022650255 65 5319502
SGTC_1011 4112-3381 17.4 µM 3.01281556039741 0.000404526776193573 yes 22 0.00129418088310608 85 2877139
SGTC_790 1575-0012 79.1 µM 3.00891396474768 0.000410936298567871 yes 23 0.00131091675046751 74 378741 YLR208W SEC13
SGTC_1357 1503-1303 39.5 µM 2.99936503520031 0.00042702282394003 yes 24 0.00135271478113347 94 292895
SGTC_2054 5233173 129 µM 2.99679021103571 0.000431459376817652 yes 25 0.00136419201582754 116 6889
SGTC_774 k060-0086 136 µM 2.99054480624305 0.000442398698677925 yes 26 0.0013924013541621 60 5911235
SGTC_2973 9094665 17.96 µM 2.98691187898015 0.000448879775213723 yes 27 0.00140905470232187 80 25237061 YIL048W NEO1
SGTC_2371 9071574 200 µM 2.97421831299494 0.000472222156359932 yes 28 0.00146868004982559 44 45596039
SGTC_1735 st034310 56.75 µM 2.93055317757769 0.000561378929785396 yes 29 0.00169179537997963 71 871153
SGTC_1033 k072-0102 21.3 µM 2.90397808654637 0.000623009958327117 yes 30 0.00184226973921002 78 5965931
SGTC_831 k061-1017 217 µM 2.89182596175383 0.000653224192153437 yes 31 0.00191505025130063 141 1240153
SGTC_3324 9138759 60.749 µM 2.87132422171802 0.000707280151293901 yes 32 0.00204378021503026 62 45595710
SGTC_2178 5812956 200 µM 2.86513441054338 0.000724393517467789 yes 33 0.00208416136773538 51 5403383
SGTC_900 1112-0045 141 µM 2.85845161227039 0.000743297749451432 yes 34 0.00212857015262247 67 56211 YIL048W NEO1
SGTC_901 1112-0062 60.1 µM 2.8434886853179 0.000787284300489801 yes 35 0.00223112968668881 46 1908457
SGTC_2181 6316240 54.2555 µM 2.79546133456233 0.000945170380557447 yes 36 0.00259128503841033 73 12779990
SGTC_2698 st077697 67.5 µM 2.72086471527823 0.00124879691649678 no 37 0.00325557010972412 66 3154499
SGTC_416 estradiol valerate 100 µM 2.70796764096309 0.00130955568155604 no 38 0.00338483113010425 71 13791 A steroid.
SGTC_2628 lathosterol 100 µM 2.65404111191446 0.00159399251633961 no 39 0.0039767068029507 108 6710616
SGTC_2030 5175110 200 µM 2.65388545487116 0.00159488934490465 no 40 0.0039785416407133 87 2831986
SGTC_268 camptothecin 39.6153 µM 2.59161216694108 0.00199288543862356 no 41 0.00477636975650636 204 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1703 st026983 48.3 µM 2.49801741458838 0.00276211762438849 no 42 0.00624450292014426 98 1104023
SGTC_1040 k898-0338 155 µM 2.46598692393624 0.00308141710947069 no 43 0.00683181610698588 119 20969351
SGTC_952 1185-0122 232 µM 2.44315467518755 0.00332892065282844 no 44 0.00727974788449719 121 678600
SGTC_2822 7994718 71.43 µM 2.4423873205127 0.00333754086594965 no 45 0.00729524177255799 90 1018011
SGTC_1267 0828-0272 9.49 µM 2.43445050778221 0.0034278847092275 no 46 0.00745720966197452 120 745334
SGTC_2681 menadione 3.18 µM 2.4311206265693 0.00346643828109375 no 47 0.00752610116462932 121 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1738 st035555 74 µM 2.42109580824637 0.0035848687220989 no 48 0.00773689920372811 156 5331140
SGTC_538 2922-0838 53.3 µM 2.40584614365034 0.00377199597736226 no 49 0.00806752920497511 166 777039
SGTC_791 1348-1292 225 µM 2.38773742147954 0.00400554859520754 no 50 0.00847622449152511 188 5437054
SGTC_1906 st060206 94.7 µM 2.36747995841935 0.00428208817842798 no 51 0.00895484500364953 145 5133468
SGTC_1418 3966-3099 2.4 µM 2.36160086000254 0.0043654795154108 no 52 0.00909811072595423 146 740335
SGTC_2855 9016525 58.44 µM 2.35393536352279 0.00447638824621721 no 53 0.00928792041923964 143 43811474
SGTC_3101 9120531 49.47 µM 2.33663239447544 0.00473603804987988 no 54 0.00972915327613532 165 24824904
SGTC_1358 1509-0022 2.48 µM 2.30997242100911 0.00516243284805014 no 55 0.0104448405159577 125 3258434
SGTC_1563 conessine 56.1 µM 2.30594560025021 0.00522972417681728 no 56 0.0105568361000428 163 441082 An anti-amoebic, histamine inhibitor.
SGTC_477 mead ethanolamide 10 µM 2.28836469617671 0.00553274350134886 no 57 0.0110581458908975 45 16061185
SGTC_3281 9140613 49.47 µM 2.27106188582681 0.00584609878755559 no 58 0.0115716159358148 131 16013766
SGTC_2851 9015922 71.43 µM 2.26892978266986 0.00588578098363727 no 59 0.011636298124889 171 2996893
SGTC_697 0508-1955 564 µM 2.26370201178883 0.00598409173988032 no 60 0.0117962243398228 188 6243113
SGTC_1678 st019265 80.2 µM 2.24970588809589 0.00625449795435116 no 61 0.0122338107537584 184 5367020
SGTC_2435 5706476 10.6 µM 2.24249637266189 0.00639796450577664 no 62 0.0124646547412635 176 5725375
SGTC_3066 9117245 49.47 µM 2.24048630308726 0.00643847980887343 no 63 0.0125296845037882 145 17176980
SGTC_2640 pentamidine 10.38 µM 2.22459894359088 0.00676677655366106 no 64 0.01305408681409 191 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1061 3448-9325 110 µM 2.21505724732912 0.00697097885938784 no 65 0.0133780677043307 131 723482
SGTC_787 4152-0075 138 µM 2.2125057135398 0.00702649805673214 no 66 0.0134658709306967 149 9566539
SGTC_2174 5790901 200 µM 2.18109889806097 0.0077425317107883 no 67 0.0145880511694181 198 786020
SGTC_3209 9113616 49.47 µM 2.16511523250464 0.00813101692077878 no 68 0.0151894308654675 196 16649353
SGTC_786 4544-0069 423 µM 2.15681142199654 0.00833952410784012 no 69 0.0155101803976829 204 748821 YLR208W SEC13
SGTC_2372 9071633 200 µM 2.15412580414332 0.00840795695607276 no 70 0.0156151537137273 149 21321366
SGTC_1979 st071809 45.3 µM 2.14706211528505 0.0085903069994774 no 71 0.0158941684248944 152 4976333
SGTC_1540 guanosine 70.6 µM 2.13672923964104 0.00886329915513405 no 72 0.0163100101760395 139 6802 Guanosine is a purine nucleoside
SGTC_2383 9036125 200 µM 2.1304912685632 0.00903175994509251 no 73 0.0165655379552872 118 79580
SGTC_2691 st077356 60.2 µM 2.12734698073157 0.00911773176832316 no 74 0.0166956319598426 203 2839272
SGTC_1876 myriocin 605 nM 2.11942040834744 0.00933764901796947 no 75 0.0170274767906257 180 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1445 4239-0156 97.7 µM 2.11117371754097 0.00957135957159692 no 76 0.0173786915071727 211 4008346
SGTC_1276 0871-0068 94.2 µM 2.09909685073898 0.00992284051236154 no 77 0.0179041820037432 161 3414906
SGTC_3336 9143619 71.43 µM 2.09248635506951 0.0101199619435007 no 78 0.0181975155486042 181 45595730
SGTC_1217 1183-1422 255 µM 2.08041518040545 0.0104887454552192 no 79 0.0187437340343818 187 2849664
SGTC_468 gf-109203x 121 µM 2.07261215035192 0.0107333182428073 no 80 0.0191041946759264 99 2396 A protein kinase C inhibitor.
SGTC_898 1000-0849 28.3 µM 2.07151472171545 0.0107681105349072 no 81 0.0191553600650466 146 6751807
SGTC_2343 7990716 14.84 µM 2.06711594188182 0.0109085544808768 no 82 0.0193616151362485 190 6456862
SGTC_2804 7954240 19.48 µM 2.05372195782082 0.0113460577222185 no 83 0.0200013050409849 225 828705
SGTC_475 α-linolenic acid 10 µM 2.04663626713882 0.011583613998062 no 84 0.0203469055824471 218 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1098 clofazimine 15.1 µM 2.04565201523843 0.0116169514957016 no 85 0.0203953099734491 252 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_710 3448-4187 58 µM 2.04269822441741 0.0117174996516643 no 86 0.0205411603547376 299 3946412
SGTC_2557 derrustone 83.84 µM 2.03436476039261 0.0120052558990826 no 87 0.0209574160706483 269 629853 An antioxidant.
SGTC_2645 abamectin 100 µM 2.03045968891781 0.0121421943143066 no 88 0.0211549173567218 219 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_307 1501-1223 22.3 µM 2.02902929351902 0.0121926914444043 no 89 0.0212276533656658 179 2830329
SGTC_1227 3909-8010 46.6 µM 2.02805031339246 0.0122273571207206 no 90 0.0212775566124608 210 15982272
SGTC_2253 7938677 135.83 µM 2.01962375810715 0.012529289261256 no 91 0.0217112144344454 172 2301972
SGTC_2081 5214970 32.255 µM 2.01438767658547 0.012720137439695 no 92 0.0219844235891642 199 2063512
SGTC_610 4215-0184 155 µM 2.01252827657767 0.0127885127115711 no 93 0.0220821395130398 219 5605015
SGTC_2062 5245942 200 µM 2.01040301353589 0.0128670536889509 no 94 0.0221942759007085 228 1376160
SGTC_3070 9117005 49.47 µM 2.01028800560466 0.012871315782004 no 95 0.0222003578060645 140 8779016
SGTC_3224 9130643 49.47 µM 2.00531884538575 0.0130566383136405 no 96 0.0224644856973663 230 17644395
SGTC_2317 5986382 200 µM 1.99894444865137 0.0132977421067432 no 97 0.0228071823735727 179 877883
SGTC_329 k048-0121 21.3 µM 1.99680586435452 0.0133794884419113 no 98 0.0229231381420263 202 6832902
SGTC_2490 carminic acid 95.39 µM 1.99362988339397 0.0135016894158745 no 99 0.0230962585522189 140 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2923 7992654 58.14 µM 1.9865624498089 0.0137770823478368 no 100 0.0234854529454144 229 2985126
SGTC_806 3966-4455 5.86 µM 1.98203382014768 0.013956082742313 no 101 0.0237377277789064 191 714982
SGTC_1812 st052057 4.327 µM 1.98131372584146 0.0139847294396964 no 102 0.0237780510296069 234 3645418
SGTC_2375 9072683 200 µM 1.97727659815772 0.0141462743833513 no 103 0.024005186704958 249 16798029
SGTC_162 k030-0015 37.8 µM 1.97663771881821 0.0141719858260125 no 104 0.0240412976975351 197 1809920 YMR134W ERG29
SGTC_2155 5570423 76 µM 1.97571175325415 0.01420932239992 no 105 0.0240937164984479 196 797402
SGTC_1552 6-methylflavone 10.6 µM 1.97398318452191 0.0142792481368227 no 106 0.0241918275079703 166 689013
SGTC_2704 st078022 71.1 µM 1.96978607213226 0.0144502684281396 no 107 0.0244314467410464 213 54697681
SGTC_2983 9022671 12.99 µM 1.96907920651731 0.0144792439929253 no 108 0.0244719981139192 209 6405161
SGTC_2370 9071495 200 µM 1.96649138427397 0.0145857501271713 no 109 0.0246209382944151 247 21791103
SGTC_1285 0929-0069 65.5 µM 1.95595942388125 0.015026194195893 no 110 0.0252349670984884 222 1206237
SGTC_608 k048-0125 159 µM 1.93014091286684 0.016154545492658 no 111 0.026794690170313 238 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_600 1495-0418 41.6 µM 1.9258556217796 0.0163486836632699 no 112 0.0270612020040417 227 5377768
SGTC_2943 9068529 45.32 µM 1.92381630380645 0.0164417711141664 no 113 0.0271888065373469 252 3270634
SGTC_873 0591-4978 488 µM 1.91963437544066 0.0166340810577668 no 114 0.0274520494003013 240 3305145
SGTC_3075 9116269 49.47 µM 1.91290959201908 0.016947362316971 no 115 0.0278798137002882 212 17015205 YNL244C SUI1
SGTC_1088 bifonazole 369 nM 1.90666090239053 0.0172429722120307 no 116 0.028282256506259 222 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2270 7924575 90.91 µM 1.90383571852432 0.0173780639976509 no 117 0.0284657915284739 241 1262135
SGTC_377 3970-0964 33.1 µM 1.90154954222196 0.017488042755658 no 118 0.0286150349058504 355 16481235
SGTC_2151 5563267 85.4165 µM 1.90151273793029 0.0174898181113486 no 119 0.0286174428313505 259 5310824
SGTC_2889 9059656 51.95 µM 1.897813747454 0.0176690356674855 no 120 0.0288603107991721 237 3949838
SGTC_2814 7977482 42.97 µM 1.89726164318046 0.0176959192933656 no 121 0.0288967073414235 342 6456762
SGTC_1736 st036774 51 µM 1.88590716728075 0.0182565923419533 no 122 0.0296537327610157 269 1272247
SGTC_2394 5221648 200 µM 1.88139845175182 0.0184833902203514 no 123 0.0299588686632755 304 788586
SGTC_1277 0873-0036 22 µM 1.88023465821577 0.0185423195717328 no 124 0.0300380520403431 302 5965735
SGTC_2969 9091408 28.7 µM 1.86540985641192 0.0193070876404019 no 125 0.0310619884245947 295 4286311
SGTC_2185 6113692 200 µM 1.860223249226 0.0195809043483046 no 126 0.0314269735212602 237 874150
SGTC_1927 st060202 13.8 µM 1.85740730754144 0.0197309428520289 no 127 0.0316266138052005 243 688887
SGTC_2415 st077333 57.7 µM 1.85114998057697 0.0200678415148912 no 128 0.0320739897004836 356 2766255
SGTC_887 0885-0007 9.62 µM 1.84895242732702 0.0201873112031281 no 129 0.0322323411753632 293 5719458
SGTC_3067 9117431 49.47 µM 1.82597048297545 0.0214732606722359 no 130 0.0339273540544143 220 17150885
SGTC_3086 9117350 49.47 µM 1.82398149137494 0.0215877397870055 no 131 0.0340774352167415 166 2679265
SGTC_3200 9114385 49.47 µM 1.82212170868907 0.021695248276173 no 132 0.0342182602411058 272 17018030 YLR208W SEC13
SGTC_1688 st021091 57.6 µM 1.81879997804687 0.021888393124311 no 133 0.0344709758784209 222 3656366
SGTC_911 3456-4043 236 µM 1.81113380075883 0.0223396981002927 no 134 0.0350600712265248 318 914281
SGTC_3093 9117344 49.47 µM 1.79682681878739 0.0232029495340115 no 135 0.0361815586737122 260 24824913
SGTC_173 1273-0061 2.693 µM 1.78387088432783 0.0240087465746689 no 136 0.0372223239949083 415 2847414 YPL266W DIM1
SGTC_132 0417-1715 25.805 µM 1.77471301239573 0.0245923996797706 no 137 0.0379726428268018 274 6769098
SGTC_2352 9027995 87.8 µM 1.77358881664687 0.0246648611256889 no 138 0.0380655944349487 235 2997347
SGTC_1656 st012921 11 µM 1.77255016866594 0.0247319676076352 no 139 0.038151637590429 250 6732821
SGTC_1424 4048-1941 275 µM 1.76595510623375 0.0251616541118564 no 140 0.0387016904662991 324 X1424
SGTC_2045 5106652 78.05 µM 1.76485201692775 0.0252341306491456 no 141 0.0387943198758453 270 673349
SGTC_1434 4073-0095 163 µM 1.76321870504019 0.0253417657328141 no 142 0.0389318050915823 274 24133745
SGTC_332 4112-0506 40.9 µM 1.75294263468689 0.02602781468784 no 143 0.039805927175436 280 2790355
SGTC_2458 5808907 16.39 µM 1.74061658624089 0.0268711487279415 no 144 0.040875404161732 250 2731747
SGTC_1295 1013-0063 9.78 µM 1.74015978604053 0.0269028358194162 no 145 0.0409154823423576 305 6826038
SGTC_668 1682-0499 62.6 µM 1.73839580466056 0.0270254917680597 no 146 0.0410705477147829 359 682214
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.73413243781439 0.0273238671746308 no 147 0.0414472935977877 342 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2821 7996764 71.43 µM 1.73376820982614 0.0273494848838788 no 148 0.0414796091829964 358 2987135
SGTC_2540 epiandrosterone 100 µM 1.73225068243227 0.0274564347499095 no 149 0.0416144693394709 424 441302 A steroid.
SGTC_2443 5493264 126.67 µM 1.72936325825599 0.0276608930684581 no 150 0.0418720507611868 304 5340055
SGTC_2575 plumbagin 510 nM 1.71430234950076 0.0287480309502555 no 151 0.0432366059357673 331 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3147 9097027 49.47 µM 1.71016782939702 0.0290526117655607 no 152 0.0436174213899347 317 25236841
SGTC_1115 galangin 695.678 nM 1.70724245414812 0.0292697335006942 no 153 0.0438884985658211 352 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2598 perillyl alcohol 100 µM 1.70431887530241 0.029488066630744 no 154 0.0441607652617647 343 10819 An apoptosis inducer.
SGTC_3225 9130819 49.47 µM 1.70218497556702 0.0296482785820756 no 155 0.0443603491645268 332 4547121
SGTC_2594 a-mangostin 100 µM 1.6952531778885 0.0301737059059068 no 156 0.0450137014392001 367 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1117 retinoic acid 1.10837 µM 1.69419371030308 0.0302546890904455 no 157 0.0451142398208327 343 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1211 1056-0033 32.3 µM 1.69067268632247 0.0305251229561402 no 158 0.0454496668702399 294 6741922
SGTC_2764 methyldopa 94.69 µM 1.67929709175835 0.0314125477637483 no 159 0.0465470787576484 358 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1333 1482-0047 286 µM 1.67663052955525 0.0316236272043386 no 160 0.0468073764865794 360 3811116
SGTC_2905 7799065 20.05 µM 1.67254905849219 0.0319489769129398 no 161 0.047208051231032 286 1296806
SGTC_335 4077-0256 27.6 µM 1.66642466249586 0.0324423580802895 no 162 0.0478144310107037 363 3121989
SGTC_1208 2323-2347 50.3 µM 1.66355902341126 0.0326753633962827 no 163 0.0481002931959956 317 5412760
SGTC_2217 6934799 96.0675 µM 1.66017513633702 0.0329522826076181 no 164 0.0484396124992091 307 675606
SGTC_2622 2-methoxyxanthone 59.94 µM 1.65961116574115 0.0329986224478531 no 165 0.0484963503169972 335 71034 A hepatoprotective.
SGTC_1554 st069299 38.7 µM 1.65617705034811 0.0332819542184503 no 166 0.0488429846861682 349 24207999
SGTC_502 l-744,832 89.3 µM 1.64638452790797 0.0341009059451645 no 167 0.0498423082369046 352 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.64073815407829 0.0345805975975889 no 168 0.0504258906050824 362 5282309
SGTC_394 menadione 8.33 µM 1.63863021935911 0.0347610936107641 no 169 0.0506451473960458 356 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1243 0416-0003 5.65 µM 1.63219723957063 0.0353167180530916 no 170 0.0513189710600382 371 2141977
SGTC_1904 st060225 78 µM 1.6309123415893 0.0354285644604825 no 171 0.0514544086124134 327 66595
SGTC_2111 5486399 200 µM 1.62940259156593 0.0355603545201153 no 172 0.051613910269264 408 689674
SGTC_2261 9010538 184.68 µM 1.62857054759942 0.0356331574411093 no 173 0.0517019816980824 291 6457250
SGTC_3029 9088683 49.47 µM 1.62422876357603 0.0360150433290006 no 174 0.0521634971092796 327 25236615
SGTC_316 k060-0003 58.6 µM 1.62333199880144 0.0360943353645491 no 175 0.0522592263455003 331 6152314
SGTC_859 0439-0102 54.6 µM 1.6203451169758 0.0363594674139279 no 176 0.0525790811553009 382 610143
SGTC_466 geldanamycin 89.2 µM 1.61770450880066 0.0365951878668141 no 177 0.0528631469277352 242 5288382 HSP90 inhibitor.
SGTC_2682 pyrogallin 40.03 µM 1.61731659088247 0.0366299214119638 no 178 0.0529049799089916 399 822798 An ATP competetive kinase inhibitor.
SGTC_462 ag-879 158 µM 1.61665282484821 0.0366894165014967 no 179 0.052976621189629 397 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1421 4029-0249 71.4 µM 1.61246560250761 0.0370665526037971 no 180 0.0534303296257709 379 2894095
SGTC_1717 st033143 58.0435 µM 1.60287307789897 0.0379424861098957 no 181 0.0544813393003496 415 674616
SGTC_2988 9073640 71.4286 µM 1.60212924914655 0.0380111079501927 no 182 0.0545635156341194 351 9102229
SGTC_406 estrone 100 µM 1.60179982709012 0.038041531078234 no 183 0.0545999406598356 363 5870 A steroid.
SGTC_1330 1469-0054 61.8 µM 1.60049325906421 0.0381623922922029 no 184 0.0547446005790123 353 7102664
SGTC_2699 st077704 54.6 µM 1.59900324685541 0.0383006046190379 no 185 0.0549099405802549 381 645852
SGTC_3050 9093513 49.47 µM 1.5958696049997 0.0385926105348799 no 186 0.0552589544537726 345 25236664
SGTC_3218 9131285 49.47 µM 1.5943163245859 0.0387380227805569 no 187 0.0554326015762751 448 17156417
SGTC_1682 st012968 530 nM 1.59070775508668 0.0390775667524109 no 188 0.0558376804159072 336 24207270
SGTC_2596 sinensetin 100 µM 1.58945494837671 0.039196013162015 no 189 0.0559788587532988 364 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2206 7254556 146.969 µM 1.58418346490032 0.0396976101587245 no 190 0.0565759874864858 282 4398905
SGTC_2712 st079126 47.7 µM 1.58176341422106 0.0399296267357013 no 191 0.056851794981312 355 3152970
SGTC_24 0417-1663 219 µM 1.58090828193499 0.0400118735531974 no 192 0.0569495052011469 371 4329390
SGTC_611 3453-1652 23.7 µM 1.57752476605089 0.0403386518295453 no 193 0.0573374140610299 417 1560575
SGTC_3309 9129340 25.759 µM 1.57700382018632 0.0403891565221121 no 194 0.0573973230336978 387 17158987
SGTC_2441 5730946 39.09 µM 1.56779218622747 0.0412907179767632 no 195 0.0584648195240212 383 1774275
SGTC_1830 st055982 50.3 µM 1.5639073495568 0.0416757936890265 no 196 0.0589196641380018 404 455313 An antimicrobial agent.
SGTC_2159 5658611 73.75 µM 1.56315320931043 0.0417508822502328 no 197 0.0590082813750286 341 793844
SGTC_2294 7971431 200 µM 1.55348132125193 0.0427236444669958 no 198 0.0601540941403756 321 5741572
SGTC_2076 5212012 200 µM 1.54997996648464 0.0430802826712212 no 199 0.060573162241545 289 604802
SGTC_2287 7945887 168.79 µM 1.5453230732369 0.0435583431005122 no 200 0.0611340685782414 394 1245853
SGTC_1156 4092-0367 4.88 µM 1.54116962384302 0.0439883256088371 no 201 0.0616377541767741 420 1357585
SGTC_112 phenothiazine 287.218 µM 1.54079961292222 0.0440267961626665 no 202 0.0616827818471694 393 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2491 paeonol 100 µM 1.53890036714414 0.0442246906395365 no 203 0.0619143107704759 338 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1342 1486-1464 234 µM 1.53870835689175 0.0442447372520975 no 204 0.0619377556193161 413 3253938
SGTC_2528 xanthyletin 44.79 µM 1.53400235267276 0.0447383560165434 no 205 0.062514536996973 359 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2981 9013952 38.96 µM 1.53375480196261 0.0447644442113821 no 206 0.0625449930626577 394 2996344
SGTC_2511 berberine 10.47 µM 1.52821388864561 0.0453515871230024 no 207 0.0632297207880122 363 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_485 niflumic acid 177 µM 1.52709298959762 0.0454711132127217 no 208 0.063368944960434 361 4488 A COX2 inhibitor.
SGTC_1432 4049-0298 68.4 µM 1.52461571966465 0.0457361733792952 no 209 0.063677487106457 379 741646
SGTC_2138 5575593 77.673 µM 1.52088697194853 0.0461374777505699 no 210 0.064144101927745 336 762213
SGTC_713 1488-1073 324 µM 1.5109892201569 0.047216445343836 no 211 0.065395598695761 366 3312542
SGTC_1555 citronellol 128 µM 1.51008472859922 0.0473160455334711 no 212 0.0655109028557257 359 8842 A terpine precursor.
SGTC_2984 9022109 38.96 µM 1.50707925830634 0.0476482096543702 no 213 0.0658951713336951 330 6459207
SGTC_1534 6-azauridine 81.6 µM 1.50706070212267 0.0476502662669218 no 214 0.0658975492737479 475 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1405 3909-7894 12 µM 1.50669829292638 0.0476904469331473 no 215 0.0659440046645092 409 7104060
SGTC_1878 temozolomide 1 mM 1.50629133437018 0.04773559916845 no 216 0.0659962008551764 368 5394 DNA alkylating agent.
SGTC_1995 st072814 61.1 µM 1.50329683598557 0.0480688936764003 no 217 0.0663812578385392 385 5769371
SGTC_3342 9147791 14.508 µM 1.50135827546587 0.0482856511449773 no 218 0.0666314598400785 409 1838168
SGTC_1572 epiandrosterone 68.9 µM 1.49727580441827 0.0487446840105016 no 219 0.0671607539619255 448 441302 A steroid.
SGTC_1875 nocodazole 6 µM 1.49354332988466 0.0491674092509992 no 220 0.0676475104649006 412 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1100 amiodarone 5.07 µM 1.48748518258741 0.0498597583729614 no 221 0.068443356916073 458 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_3083 9117465 49.47 µM 1.48380194913748 0.0502844797863101 no 222 0.0689307349376548 439 16420915
SGTC_3123 9126162 49.47 µM 1.48358528080107 0.0503095537952078 no 223 0.068959488333548 414 25239884
SGTC_1596 piperlongumine 63 µM 1.47635952277692 0.0511514789345038 no 224 0.0699237014309587 458 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_671 0560-0003 407 µM 1.47454391662668 0.0513647811627147 no 225 0.0701676012096601 417 3238678
SGTC_1588 farnesol 29.9 µM 1.47421486943407 0.0514035141238226 no 226 0.0702118737823138 437 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3256 9138902 49.47 µM 1.4726601005014 0.0515868441398829 no 227 0.0704213551484398 369 17228773
SGTC_988 1497-1057 103 µM 1.47119233333745 0.0517603920596252 no 228 0.0706195549788842 443 3533044
SGTC_2591 skatole 100 µM 1.46908671353985 0.0520101693337286 no 229 0.070904635512825 423 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2521 angolensin 13.4 µM 1.46567393479093 0.0524170400399097 no 230 0.0713685692060064 400 821428 A flavenoid.
SGTC_2438 5259590 200 µM 1.46461444374974 0.0525438650462461 no 231 0.0715130695220535 446 1201127
SGTC_2430 5571206 200 µM 1.46063709988653 0.0530221424698219 no 232 0.0720575296147149 503 1731771
SGTC_2404 5161160 200 µM 1.46005237701999 0.0530927458327888 no 233 0.0721378397722615 484 2831543
SGTC_2106 5357045 167.29 µM 1.45595079827996 0.053590095556435 no 234 0.0727031107248151 461 668842
SGTC_656 4090-1979 187 µM 1.45087476955759 0.054210707444458 no 235 0.0734073673316665 493 22330961
SGTC_888 0916-0002 6.97 µM 1.44381376108387 0.0550834515808136 no 236 0.0743956850205916 449 2802138 YIL048W NEO1
SGTC_181 1447-1644 8.07 µM 1.44324438841225 0.0551543072111468 no 237 0.0744758196882564 448 534600
SGTC_916 4466-0038 42 nM 1.4414767940479 0.0553747344304113 no 238 0.0747250143474374 591 5722064 YGL116W CDC20
SGTC_2338 7999974 200 µM 1.43656394381266 0.0559910443456074 no 239 0.0754209674529222 493 315925
SGTC_418 lividomycin a 100 µM 1.43575216017235 0.0560934003038307 no 240 0.0755364385633674 469 72394 An antibiotic.
SGTC_3175 9106517 49.47 µM 1.43262898043304 0.0564885715016039 no 241 0.0759819475904048 429 41468073
SGTC_654 1124-0271 80.9 µM 1.42250290789189 0.0577849107762211 no 242 0.0774401539740932 502 5403748
SGTC_1235 benzylparaben 21.5 µM 1.41443863885867 0.0588339353358115 no 243 0.0786165759576996 466 7180
SGTC_2465 5809242 33.21 µM 1.41372761412504 0.0589271399143704 no 244 0.078720947093461 417 2731748
SGTC_2376 9072922 81.32 µM 1.40907403732069 0.0595400166865301 no 245 0.0794066384608005 513 17087968
SGTC_2033 5192550 145 µM 1.40785969235538 0.0597007652245915 no 246 0.0795863103158702 442 182073
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.40692486334846 0.0598247444156273 no 247 0.0797248350122428 435 616764
SGTC_2034 5197015 53.07 µM 1.40403744569899 0.0602089542470754 no 248 0.0801538496343537 492 780676
SGTC_1233 0325-0408 14.2 µM 1.40069191392247 0.0606565349574655 no 249 0.0806531108846642 478 12874
SGTC_2674 ligustilide 100 µM 1.39644691076069 0.0612281923477468 no 250 0.0812899785119954 431 5319022 A signalling regulator.
SGTC_1972 st070201 17.4 µM 1.39344540895999 0.0616349268395521 no 251 0.0817425711513416 491 2829099
SGTC_2875 9039966 71.43 µM 1.39192321236893 0.0618420049114267 no 252 0.0819728259369394 419 6463691
SGTC_1384 3089-0840 101 µM 1.38894180965262 0.0622491649318777 no 253 0.0824252227535459 438 1069836
SGTC_821 1114-0266 29.2 µM 1.38844286321075 0.0623175081250278 no 254 0.0825011159493004 464 3123235
SGTC_1298 1079-1278 263 µM 1.38737391128533 0.0624641247957209 no 255 0.0826638879745397 502 2840950
SGTC_1556 plumbagin 1.48 µM 1.38584745885803 0.0626739579802851 no 256 0.0828967435951641 418 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2134 5324836 1.464 µM 1.38421870895576 0.0628984588615465 no 257 0.0831457481814164 413 699272
SGTC_179 1273-0063 6.77 µM 1.37809551127209 0.0637480667380479 no 258 0.0840869006358156 432 3108139
SGTC_743 1275-0778 158 µM 1.37686955683867 0.0639192384993845 no 259 0.0842762904511736 520 2849257 YMR203W TOM40
SGTC_1375 2910-0797 186 µM 1.37597886818485 0.0640438233768914 no 260 0.0844140878692745 491 742508
SGTC_2152 5568786 200 µM 1.36766561165073 0.0652157607425966 no 261 0.0857083843517783 496 5399883
SGTC_280 3448-3607 3.04 µM 1.36222218623294 0.065992101693955 no 262 0.0865638880556513 478 626179
SGTC_545 4218-0007 221 µM 1.36163388311805 0.0660764324226848 no 263 0.0866567282625446 492 2840508
SGTC_1008 4106-0037 6 µM 1.35603523481623 0.0668831578354748 no 264 0.0875439787721154 483 2905394
SGTC_1031 k035-0009 16 µM 1.35350437612455 0.0672503280629284 no 265 0.0879472764744929 569 5180959
SGTC_1763 st044482 94.5 µM 1.34742399782486 0.0681388215168519 no 266 0.0889218579948461 528 88505
SGTC_3332 9141069 11.198 µM 1.34703523218626 0.0681959365170471 no 267 0.0889844429142352 452 17332883
SGTC_986 1493-0483 84 µM 1.34406976483597 0.0686328209704609 no 268 0.0894629140668795 487 40079
SGTC_3174 9107204 49.47 µM 1.34251289985708 0.0688630469842029 no 269 0.0897148752890955 514 3938802
SGTC_1249 0481-0015 10.2 µM 1.33805627506869 0.0695253754076951 no 270 0.0904390464124996 446 4227577
SGTC_1085 doxorubicin 7.67 µM 1.337466132329 0.0696134469707024 no 271 0.0905352650810409 567 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_865 0488-0499 301 µM 1.3366444272077 0.0697362194109463 no 272 0.090669364931595 566 9634651
SGTC_2858 9025781 8.96 µM 1.3341633722269 0.0701079297613216 no 273 0.0910751603042067 653 4894980 YPL153C RAD53
SGTC_1203 3992-3522 103 µM 1.33358043844767 0.0701954853147089 no 274 0.0911706986736985 565 5322312
SGTC_1548 st061468 90.8 µM 1.33279974046512 0.0703128763867706 no 275 0.0912987654667052 529 390799
SGTC_1081 sertraline 6 µM 1.33172012649757 0.0704754631625501 no 276 0.0914760865391652 577 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1937 st074714 47.2 µM 1.32930402781056 0.0708403677154591 no 277 0.0918738429822482 523 17250970
SGTC_2892 9047358 58.44 µM 1.32904305657289 0.0708798690297611 no 278 0.0919168825777276 470 6466771
SGTC_563 tetrahydrosecaminediol 614 µM 1.32386640033574 0.0716669231143783 no 279 0.0927737094260745 550 334274 A psychoactive constituent of the cannabis plant.
SGTC_1146 3579-1023 7 µM 1.32341412353444 0.0717360040819025 no 280 0.0928488487532888 590 X1146
SGTC_3012 9080433 71.4286 µM 1.32178524749022 0.0719852226463745 no 281 0.0931198360917125 551 17688859
SGTC_1686 st019653 115.5 µM 1.32041852949562 0.0721948426687709 no 282 0.0933476602156981 503 97252
SGTC_1634 st006576 41 µM 1.31911106005185 0.0723958130198946 no 283 0.0935659930777816 522 3915356
SGTC_2323 6148992 148.28 µM 1.31886438886897 0.0724337767170795 no 284 0.0936072266740052 471 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_501 nsc-95397 161 µM 1.3116024632807 0.0735582633709646 no 285 0.0948271507379665 510 262093
SGTC_2718 lomofungin 53.02 µM 1.31103854239648 0.0736461401970088 no 286 0.0949223711862099 523 5351222 A RNA synthesis inhibitor.
SGTC_2727 riluzole 51.77 µM 1.31100995530976 0.073650597111711 no 287 0.0949272001131567 477 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1318 1280-3875 124 µM 1.30378402446643 0.0747837940152756 no 288 0.0961536155400048 562 373245
SGTC_1569 carminic acid 40.6 µM 1.30258961057739 0.0749723807939242 no 289 0.0963574533120187 567 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_721 1187-1332 279 µM 1.30143874284713 0.0751544349731757 no 290 0.0965541597651568 446 25730
SGTC_2534 helenine 20.12 µM 1.30098371035763 0.0752265088500827 no 291 0.0966320152980182 479 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2408 sulbentine 18.36 µM 1.30046104902124 0.0753093596638696 no 292 0.096721498939705 545 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2810 7959871 45.46 µM 1.29962778636345 0.0754415899491362 no 293 0.096864285745709 608 2974535
SGTC_1502 4534-4282 27.7 µM 1.29763446134642 0.0757586281574144 no 294 0.0972064871854405 511 3278949
SGTC_744 1594-0068 283 µM 1.29641984754479 0.0759523093866572 no 295 0.0974154389085868 603 668392
SGTC_1758 st042942 75.2445 µM 1.29394832176124 0.0763475805144427 no 296 0.0978416359158385 528 669317
SGTC_932 2857-0803 154 µM 1.28997257869453 0.0769867024996512 no 297 0.0985300895341891 599 674898
SGTC_320 4092-0846 5.34 µM 1.28462851067025 0.0778521863152048 no 298 0.0994610653932542 554 1359356
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.27931998016972 0.078719205602313 no 299 0.10039219974265 590 688664
SGTC_857 0438-0306 1.35 µM 1.27752022377106 0.0790148068757695 no 300 0.100709322572437 558 4686136
SGTC_25 0118-0223 35.662 µM 1.27570996536545 0.0793129803778893 no 301 0.101029032267958 546 5333628
SGTC_2337 9009472 200 µM 1.26863661890081 0.0804862241188377 no 302 0.102285348752401 629 5742383
SGTC_917 harmaline 728.087 nM 1.26540702420796 0.0810262512789534 no 303 0.102862729260141 576 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1094 duloxetine 25.4 µM 1.26439522831509 0.0811959970900872 no 304 0.103044102354661 569 60834 A selective serotonin reuptake inhibitor.
SGTC_2419 paclitaxel 166.5 µM 1.26422350800888 0.081224832679157 no 305 0.103074907736348 629 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_284 0988-0104 32.6 µM 1.26295180387335 0.0814386200996615 no 306 0.103303250475902 602 4666532
SGTC_877 0771-0151 33.1 µM 1.2627032532264 0.0814804537247429 no 307 0.103347922230795 611 6166523
SGTC_2202 7226349 200 µM 1.26189076961146 0.0816173161327248 no 308 0.103494046929571 520 844334
SGTC_3168 9103419 49.47 µM 1.25977290097003 0.0819748846058264 no 309 0.103875649098259 464 16649256
SGTC_3173 9105693 49.47 µM 1.25476457069232 0.0828251561108566 no 310 0.104782118791856 593 17096658
SGTC_3230 9131665 49.47 µM 1.24956562818252 0.0837147896925672 no 311 0.105729132822205 443 15943720
SGTC_2771 fluoxetine 41.05 µM 1.24937097773266 0.0837482367963013 no 312 0.105764709180799 552 3386 A selective serotonin reuptake inhibitor.
SGTC_752 1896-0090 130 µM 1.24764380634223 0.0840454593031388 no 313 0.106080764259218 585 772567
SGTC_3078 9116413 49.47 µM 1.24613958855057 0.0843049591724018 no 314 0.106356576505965 525 17177322
SGTC_2242 6630449 61.2675 µM 1.24536050096182 0.0844395994750126 no 315 0.106499632821937 501 691249 YDR170C SEC7
SGTC_1977 st070720 65.3 µM 1.24364132651783 0.0847372743346666 no 316 0.106815799568176 530 682188
SGTC_1000 4048-0884 8.67 µM 1.24099347355 0.0851972881561579 no 317 0.107304079930618 597 13040088
SGTC_2218 6965428 192.983 µM 1.239245873399 0.0855019237142178 no 318 0.10762722841335 597 675684
SGTC_2434 5670830 169.91 µM 1.23860853938217 0.0856132243167695 no 319 0.107745252064972 588 1549830
SGTC_1539 benzyladenosine 56 µM 1.23760726398114 0.0857883007337597 no 320 0.107930859850681 564 92208 A nucleotide analog.
SGTC_1393 3470-5649 58.2 µM 1.23388696909556 0.0864411550167102 no 321 0.108622512942264 489 4108395
SGTC_442 cape 100 µM 1.22481894926414 0.0880480038579649 no 322 0.110321721841088 544 5281787
SGTC_478 N-arachidonylglycine 10 µM 1.21714944684081 0.0894243323898697 no 323 0.111773680151158 458 5283389
SGTC_2061 5245884 80.95 µM 1.21639611544529 0.0895603796287475 no 324 0.111917031515376 625 573863
SGTC_1090 efavirenz 20.7 µM 1.2140605591236 0.0899831456987757 no 325 0.112362299812074 602 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2991 9074669 71.4286 µM 1.21348432826336 0.0900876786867529 no 326 0.112472351272695 680 17333109
SGTC_936 3005-4620 401 µM 1.20837311005483 0.0910188475998498 no 327 0.113451889089331 684 777207
SGTC_544 k015-0020 52.4 µM 1.2078520419219 0.0911141760666377 no 328 0.113552089699732 592 3008304
SGTC_379 3970-0972 5.9 µM 1.20575525837528 0.0914985273401321 no 329 0.113955935785871 606 2898042 YBL034C STU1
SGTC_1525 8-methoxypsoralen 92.5 µM 1.2049490463197 0.0916466295806731 no 330 0.114111486432072 687 4114 Related to psoralen; DNA damaging agent.
SGTC_129 0088-0017 176.636 µM 1.20167549025918 0.0922498112765228 no 331 0.11474464039035 585 182446
SGTC_1315 1237-0019 3.69 µM 1.20087486036472 0.0923977806401339 no 332 0.114899873705029 642 825140
SGTC_3128 9127691 49.47 µM 1.20023939897856 0.09251534915243 no 333 0.115023188955799 514 41316314
SGTC_428 3448-4153 16.5 µM 1.19611475654779 0.0932811526214327 no 334 0.115825889908749 541 3834874
SGTC_2658 polymyxin b sulfate 77.05 µM 1.19562658936093 0.0933720974426742 no 335 0.115921155251621 658 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3194 9111903 49.47 µM 1.19465619384038 0.0935530751705219 no 336 0.116110692156105 612 17087251
SGTC_127 0180-0333 59.125 µM 1.19410884002342 0.09365527027164 no 337 0.116217697855541 718 771601
SGTC_3108 9121785 49.47 µM 1.19375188182273 0.0937219614614027 no 338 0.116287519587379 606 17140271
SGTC_1314 1222-0010 41.1 µM 1.19227994204052 0.0939973372020868 no 339 0.116575748330425 615 3526027
SGTC_1526 st051518 75 µM 1.1889733033779 0.094618131290301 no 340 0.117225086226487 585 673993
SGTC_572 0960-0087 17.7 µM 1.18444551254266 0.0954730817715401 no 341 0.118118376543662 663 6796365
SGTC_556 4058-0063 51.5 µM 1.18132187566866 0.0960662014312434 no 342 0.118737440122069 686 6615692
SGTC_3135 9127742 49.47 µM 1.17920045928479 0.0964705603075214 no 343 0.119159181627063 591 3643468
SGTC_1675 st018485 24.5 µM 1.17727600819569 0.0968384565616758 no 344 0.119542679822975 645 3323024
SGTC_2826 7992541 19.48 µM 1.17672086496417 0.0969447741933732 no 345 0.119653468543315 612 2985066
SGTC_80 0159-0065 512.242 µM 1.17476365593026 0.0973202904990559 no 346 0.120044642112116 525 1548079
SGTC_756 0508-1999 28.3 µM 1.17279468887153 0.0976991384241713 no 347 0.120439074249474 623 6753853
SGTC_1193 1488-0126 41.5 µM 1.17246236133413 0.0977631878992943 no 348 0.120505737489745 645 1384710
SGTC_2800 7887935 81.82 µM 1.1714040110111 0.0979673688278644 no 349 0.120718210392456 621 2961002
SGTC_2103 5378138 10 µM 1.16968856287774 0.0982989830335876 no 350 0.121063161205149 717 244142
SGTC_692 k241-0027 77.8 µM 1.16752003158194 0.0987193585397614 no 351 0.121500211785042 629 3600480
SGTC_2264 7948757 110.76 µM 1.15945680482618 0.10029397738589 no 352 0.123135016887134 619 2971411
SGTC_1811 st050069 61.5 µM 1.15900465390491 0.100382814904996 no 353 0.123227144024274 615 3877702
SGTC_1332 1480-0653 17.5 µM 1.1586088021674 0.100460638028566 no 354 0.123307839676131 639 5749438
SGTC_219 mitoxanthrone 164.414 µM 1.15258024705792 0.101651276534024 no 355 0.1245413573524 647 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_855 0428-0020 25 µM 1.15244157281862 0.101678785047168 no 356 0.124569832974284 599 6812414
SGTC_1420 4'-methoxyflavone 42 µM 1.14986205632114 0.102191466706957 no 357 0.125100345496921 666 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3163 9099914 49.47 µM 1.14818998387095 0.102524795880464 no 358 0.125445071611456 616 16268368
SGTC_115 0527-0192 112.043 µM 1.14255900734617 0.103653148417846 no 359 0.126610866764016 763 4233931
SGTC_987 1497-1013 404 µM 1.1423403845651 0.103697137717238 no 360 0.126656280453829 631 1676435
SGTC_2455 5377712 9.75 µM 1.14114584561045 0.103937731243184 no 361 0.126904617875413 588 2243908
SGTC_942 3253-1115 227 µM 1.14001431023251 0.104166008262654 no 362 0.127140169654205 663 46497897
SGTC_1951 sophoraflavanone G 9.2 µM 1.13632056233592 0.10491371774602 no 363 0.127911214077706 701 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_547 1120-0019 610 nM 1.13365788236541 0.105455117479203 no 364 0.128469041528615 670 3676939
SGTC_2930 9013230 14.89 µM 1.12912885141407 0.106380636862828 no 365 0.129421741004325 724 2995857
SGTC_2166 5933061 31.504 µM 1.12789087612603 0.106634638104194 no 366 0.129683003784079 658 2877375
SGTC_2772 vinpocetine 57.06 µM 1.12768607440922 0.106676700403751 no 367 0.129726260405615 658 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_387 norethindrone acetate 66.7 µM 1.12631512900218 0.106958574390669 no 368 0.130016078124211 644 541197
SGTC_49 0717-0965 32.132 µM 1.12444386727943 0.107344182796483 no 369 0.13041238553447 688 5889349 YGL099W LSG1
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.1185052334535 0.108574583876964 no 370 0.131675636302554 683 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2080 5212524 12.4 µM 1.11539059322748 0.109223934111667 no 371 0.132341539408638 659 260183
SGTC_2728 chlorpromazine 9.18 µM 1.11283509843256 0.109758792129764 no 372 0.13288962910728 585 2726 A thorazine and dopamine antagonist.
SGTC_2319 6033012 152.6 µM 1.11111315890168 0.110120247949943 no 373 0.133259822233914 633 847246
SGTC_996 3970-0799 1.8 µM 1.11099302624184 0.110145497067655 no 374 0.133285675543174 880 6615648 YGL040C HEM2
SGTC_1454 4239-0054 42.6 µM 1.10784688038184 0.110808223544889 no 375 0.133963974881026 755 1340767
SGTC_884 0851-0618 334 µM 1.10512511894487 0.111383855533275 no 376 0.134552688846976 727 9642473
SGTC_456 gingerol 170 µM 1.10494789853657 0.111421410392591 no 377 0.134591082909534 687 442793 A herb.
SGTC_1780 st038448 24.544 µM 1.10391880382854 0.111639665441743 no 378 0.134814180596436 696 728868 YDL195W SEC31
SGTC_1331 1472-0049 76.2 µM 1.10374030272479 0.111677553868044 no 379 0.134852903699891 678 24051409
SGTC_372 0155-0182 15.9 µM 1.10246044401017 0.111949484566261 no 380 0.135130773104674 761 771486
SGTC_3316 9136639 10.545 µM 1.09851376186114 0.112791013579562 no 381 0.135990105853442 693 4903665
SGTC_1603 st002045 67.8 µM 1.0967624989879 0.113165868720987 no 382 0.136372613716015 718 5887985
SGTC_2749 bexarotene 57.39 µM 1.09102059646442 0.114401146756811 no 383 0.137631909903163 688 82146 An retinoic acid receptor inhibitor.
SGTC_2316 5844804 197.44 µM 1.09037087336471 0.114541526498816 no 384 0.137774903399453 856 776813
SGTC_2580 diallyl disulphide 81.36 µM 1.08921856059082 0.114790797669446 no 385 0.13802875796441 668 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_968 1309-0633 340 µM 1.08878361568038 0.114884986293679 no 386 0.138124659228552 704 3761976
SGTC_265 mycophenolic acid 32.932 µM 1.08826815514103 0.114996681983399 no 387 0.138238372250073 775 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2765 myclobutanil 7.74 µM 1.08734019814843 0.115197956587922 no 388 0.138443244763005 715 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2836 9010338 19.48 µM 1.08669572678684 0.115337890224071 no 389 0.138585651574429 644 2994051
SGTC_914 3820-6779 408 µM 1.08463982749388 0.115785093562955 no 390 0.139040604011901 690 2893481
SGTC_3253 9135987 49.47 µM 1.08380519460229 0.115966995569839 no 391 0.139225590765906 655 4182430
SGTC_1058 3448-5425 97.3 µM 1.08312216218145 0.116116008269549 no 392 0.139377101583506 695 7279705
SGTC_113 0099-0221 2.5 µM 1.08160945490924 0.116446509340233 no 393 0.139713050740953 702 89219
SGTC_1757 st041620 31.8375 µM 1.08043007953968 0.116704645526342 no 394 0.139975353613313 726 5289815
SGTC_3041 9091929 49.47 µM 1.07906837878443 0.117003192585288 no 395 0.140278623169206 747 25236887
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.0781798499958 0.117198290270813 no 396 0.140476751217565 779 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3323 9138564 53.9225 µM 1.07349723756204 0.118230277023995 no 397 0.141524038720436 790 43912313 YNL103W MET4
SGTC_3267 9137951 49.47 µM 1.07281481706033 0.118381208397065 no 398 0.141677105696784 691 16643986
SGTC_1299 1079-1439 3.74 µM 1.07265473716758 0.118416633081702 no 399 0.141713027862568 690 323161
SGTC_3195 9113082 49.47 µM 1.06267396216766 0.120640130907589 no 400 0.143964916386929 720 17018038
SGTC_745 0469-0705 296 µM 1.06258878269068 0.120659232681663 no 401 0.143984238095772 836 3486736
SGTC_2878 9043973 25.97 µM 1.0615572646833 0.120890722977241 no 402 0.144218361585135 720 6465167
SGTC_2272 7805186 180 µM 1.06151222140524 0.120900838576725 no 403 0.144228590896104 752 2956062 YPR165W RHO1
SGTC_3205 9113483 49.47 µM 1.06088205083501 0.121042421668371 no 404 0.14437175367791 754 17018033
SGTC_2214 7179297 48.276 µM 1.05905858896437 0.121452763542858 no 405 0.144786548935971 754 769744
SGTC_823 0417-1665 178 µM 1.05891089488821 0.121486042570815 no 406 0.144820181010361 751 3429856
SGTC_278 4092-0821 23.9 µM 1.05242545109909 0.122953693948658 no 407 0.146302198414085 762 877900
SGTC_417 st075190 100 µM 1.05108204004536 0.12325925465292 no 408 0.146610455991903 778 222757
SGTC_3280 9140961 49.47 µM 1.04878867697984 0.123782112013543 no 409 0.147137694997871 717 4901226
SGTC_1209 2323-2347 50.3 µM 1.04712660640572 0.124162011890621 no 410 0.147520594786551 752 5412760
SGTC_3148 9097893 49.47 µM 1.04540463316837 0.124556463255294 no 411 0.147917998131902 694 17174100
SGTC_1929 genistein trimethyl ether 50.5 µM 1.0441841130707 0.124836577044042 no 412 0.148200107884232 763 136420
SGTC_1491 4138-0063 26.5 µM 1.04408650748284 0.124858996872793 no 413 0.148222683873916 728 23883227
SGTC_1441 4106-0040 13 µM 1.04334415163625 0.125029606750365 no 414 0.148394464688455 767 2904180
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.03551357997878 0.126839167164249 no 415 0.15021456388765 752 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_716 1683-5115 658 µM 1.03435107471411 0.127109356106398 no 416 0.150486033898475 853 723597
SGTC_2514 salinomycin 42.74 µM 1.03431636508974 0.127117429454237 no 417 0.150494144364686 856 23682228 A polyether potassium ionophore.
SGTC_294 k038-0071 157 µM 1.03159923349024 0.127750533112106 no 418 0.151129949816832 766 24152826
SGTC_606 k015-0008 38.6 µM 1.03131072091282 0.127817886299998 no 419 0.15119756621046 847 1970475
SGTC_871 0574-0004 149 µM 1.0311357076668 0.127858755121105 no 420 0.15123859247543 798 9551173
SGTC_1312 1218-2183 165 µM 1.03025265098521 0.128065103640514 no 421 0.151445709840536 800 6744073
SGTC_1978 st071761 42 µM 1.02432648997783 0.129455886355048 no 422 0.152840544989323 740 5147680
SGTC_1450 4112-4260 37.6 µM 1.02262871495206 0.12985625056755 no 423 0.153241713728826 816 1633175
SGTC_187 1488-2104 32.728 µM 1.02255012371061 0.129874804456604 no 424 0.153260301003102 797 2852859
SGTC_1627 st003713 25.6 µM 1.02099458620272 0.130242414826133 no 425 0.153628501834822 834 16195070 YER133W GLC7
SGTC_1414 3917-0015 5.4 µM 1.02077264250636 0.130294924009584 no 426 0.153681084342961 789 6618702
SGTC_2572 astragaloside iv 100 µM 1.01988879413357 0.13050417708665 no 427 0.153890602332521 762 45006101 An anti-inflammatory agent.
SGTC_118 0083-0097 135.343 µM 1.01896732074346 0.130722585304378 no 428 0.154109240593114 977 5207356
SGTC_1924 st058459 75.1 µM 1.0165753860664 0.131290701972834 no 429 0.154677734171388 758 688683
SGTC_1631 benzylvanillin 81.9 µM 1.01652772451737 0.131302039530767 no 430 0.154689076004182 783 75506
SGTC_1642 st009582 77.7 µM 1.01619912039228 0.131380225097877 no 431 0.154767287600162 743 6739311
SGTC_1655 st012546 55.1 µM 1.01308578932502 0.132122582516963 no 432 0.155509592695087 762 720985 YLR208W SEC13
SGTC_1007 4101-0031 70 µM 1.01293314684004 0.132159053544301 no 433 0.155546047229923 828 1146276
SGTC_2118 5526350 200 µM 1.00985573165021 0.132895824400566 no 434 0.156282207180678 819 743594
SGTC_1060 3448-7350 82 µM 1.00856215339127 0.133206365514442 no 435 0.156592332857596 793 570178
SGTC_1467 k284-1082 293 µM 1.0073260203758 0.13350358234731 no 436 0.156889064769188 836 3334705
SGTC_1270 0831-1170 17.3 µM 1.00723132835408 0.133526368967221 no 437 0.15691181069517 855 6764716
SGTC_1529 apigenin 74 µM 1.00708579352388 0.133561395578239 no 438 0.156946773777846 792 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_305 1682-2595 20.8 µM 1.00657012535066 0.133685554927126 no 439 0.157070698422995 821 226033
SGTC_2469 5655019 90.81 µM 1.00479787680056 0.134112870712175 no 440 0.15749709323248 861 2788239
SGTC_1971 st069429 63.5 µM 1.00245275598947 0.134679755578514 no 441 0.158062486636271 786 1246522 YGL099W LSG1
SGTC_2751 anetholtrithion 17.25 µM 1.00021155943725 0.135223053568222 no 442 0.158604068156136 781 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1561 5-methoxyflavone 52.9 µM 0.99992691291626 0.135292163326895 no 443 0.158672939512333 765 94525
SGTC_1618 st003135 44.5 µM 0.996006176310154 0.136246548686034 no 444 0.159623572130623 784 1270615
SGTC_1138 3761-0006 1.03 µM 0.99478807182651 0.136543995296146 no 445 0.159919674422851 813 12061087
SGTC_689 0833-0039 98 µM 0.994627829692936 0.136583157545883 no 446 0.159958653519507 846 5374726
SGTC_3180 9109287 49.47 µM 0.991462029135713 0.137358435956708 no 447 0.160730012283555 760 18891271
SGTC_1288 0973-0013 65.5 µM 0.989323917438439 0.137883738833635 no 448 0.161252342860402 837 4315430
SGTC_317 4495-0002 170 µM 0.988354251313738 0.138122422794437 no 449 0.161489592260623 763 15991618
SGTC_1386 3228-0095 33.8 µM 0.987983108185553 0.138213854435276 no 450 0.161580460503359 777 870181
SGTC_2877 9040724 71.43 µM 0.987479462152132 0.138337994335317 no 451 0.161703823182467 829 6463895
SGTC_1486 3970-0793 4.53 µM 0.987386408842329 0.138360938657108 no 452 0.161726622306562 839 2844330
SGTC_328 k915-0120 63.5 µM 0.986398338429857 0.138604728949891 no 453 0.16196884006506 817 6624543
SGTC_549 1661-1316 519 µM 0.985775293809762 0.138758605431136 no 454 0.162121696018854 850 2857282
SGTC_1665 st014639 11.4 µM 0.98292291262247 0.139464557780867 no 455 0.162822690003926 857 981133 YIL048W NEO1
SGTC_415 dibenzyl ketone 100 µM 0.980155906573722 0.140151710765173 no 456 0.163504583045252 831 7593
SGTC_1739 st037196 92.5 µM 0.980090679510575 0.140167936828818 no 457 0.163520679758318 879 612214
SGTC_846 0335-0850 148 µM 0.978484977055543 0.140567778182193 no 458 0.163917258948269 815 6819598
SGTC_1057 3448-5381 134 µM 0.978292252162212 0.1406158212424 no 459 0.163964900393237 855 5497911
SGTC_989 1501-0895 10.3 µM 0.977773556191121 0.140745178742298 no 460 0.164093166260723 844 2830112
SGTC_1783 st039459 87.517 µM 0.97751625575744 0.140809376807561 no 461 0.164156817009594 877 729761
SGTC_2025 5147754 141 µM 0.974969218554008 0.141445950259712 no 462 0.164787764469848 828 315777 YLR208W SEC13
SGTC_626 0214-0009 33 µM 0.974190549525571 0.141640949345193 no 463 0.164980968074401 861 3437874
SGTC_940 3232-1287 54.8 µM 0.971664239880068 0.142274856785715 no 464 0.165608806264156 838 1585493 YIL048W NEO1
SGTC_358 0075-0058 9.45 µM 0.968448351497665 0.143084568069081 no 465 0.166410250789175 905 1069125
SGTC_1692 fluoroquinolonic acid 71 µM 0.968222064237891 0.143141660732693 no 466 0.166466738899675 816 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3140 9094243 49.47 µM 0.966189724837892 0.143655113178006 no 467 0.166974626750334 914 19291112
SGTC_861 0443-0273 110 µM 0.96595595513874 0.143714252618406 no 468 0.167033110535527 850 6149169
SGTC_5 0352-0601 109.883 µM 0.96276123582829 0.144524104323164 no 469 0.16783367911285 806 762456
SGTC_1010 4112-3296 15.2 µM 0.956572011122149 0.14610178789175 no 470 0.169391660741838 889 704384
SGTC_2977 9011197 71.43 µM 0.949967473371505 0.147798052710593 no 471 0.171064390120702 781 2704722
SGTC_618 k072-0232 33.2 µM 0.948338142878656 0.148218538727414 no 472 0.171478669426521 825 5872756 YGL099W LSG1
SGTC_2807 7945238 51.95 µM 0.944285517779693 0.14926787957552 no 473 0.172511882255501 847 17148797
SGTC_2911 7942208 15.64 µM 0.942644918822823 0.14969408480161 no 474 0.172931277935149 806 1243384
SGTC_2216 7189485 200 µM 0.941813589176727 0.149910362543036 no 475 0.173144043278125 898 731273
SGTC_353 1988-1175 58.3 µM 0.941503003727134 0.149991217531603 no 476 0.173223575349688 819 2788357
SGTC_1806 st050005 60.3 µM 0.939557705787102 0.1504983000233 no 477 0.173722239688325 845 5194765
SGTC_2989 9073649 71.4286 µM 0.938862250766369 0.150679861672131 no 478 0.173900736387709 934 21367202
SGTC_643 k048-0106 28.4 µM 0.937795842411161 0.150958550881176 no 479 0.174174669062867 861 6763920
SGTC_1145 3546-0597 10.2 µM 0.937498646225906 0.151036279560394 no 480 0.174251059900759 879 875334
SGTC_607 4491-0986 66.8 µM 0.937129816445872 0.151132780316885 no 481 0.174345892926261 900 698981 YDR232W HEM1
SGTC_1144 3486-0183 12.5 µM 0.936121796703918 0.15139672818552 no 482 0.174605240862813 898 6744069
SGTC_1620 st003704 16.5 µM 0.934747356641882 0.151757116109812 no 483 0.174959257614404 884 2834414
SGTC_3199 9111318 49.47 µM 0.933435071429129 0.152101738163531 no 484 0.175297689752254 847 8548020
SGTC_2828 7998861 71.43 µM 0.932416963003737 0.152369463555268 no 485 0.175560540844874 797 2988188
SGTC_978 1416-0512 87.4 µM 0.931790547831248 0.15253434323989 no 486 0.175722390220937 893 6814003
SGTC_1143 3454-2408 5.08 µM 0.931439979751889 0.152626668441093 no 487 0.175813009128936 855 X1143
SGTC_1222 0366-0074 1.18 µM 0.93075426449033 0.152807364771226 no 488 0.175990346329784 942 286520
SGTC_1356 1502-0781 85.8 µM 0.930489482000901 0.152877176910442 no 489 0.176058853719962 847 567702
SGTC_1071 trifluoperazine 6.31 µM 0.930235962635318 0.152944039247805 no 490 0.176124462811826 899 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_809 3998-0021 90 µM 0.926799708015127 0.153852217583167 no 491 0.177015268301267 870 715485
SGTC_1394 3474-0001 65.7 µM 0.926360091211646 0.153968662257214 no 492 0.177129438437251 761 5017666 YIL048W NEO1
SGTC_1077 5-fluorocytosine 377 nM 0.925671882733449 0.154151070390849 no 493 0.177308262149464 855 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_521 r062-0005 13.8 µM 0.922404259288226 0.155019096609201 no 494 0.17815887445358 855 2832033
SGTC_799 1310-0557 151 µM 0.92012037350791 0.155627711041769 no 495 0.178754929407285 883 5354492
SGTC_886 0866-0150 153 µM 0.919954859044234 0.155671878828798 no 496 0.178798174572653 950 271463
SGTC_393 acivicin 6.25 µM 0.917070943363494 0.1564427829569 no 497 0.179552732988784 826 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_152 4469-0003 551.229 µM 0.916772999963849 0.15652256971958 no 498 0.179630801910598 897 697280
SGTC_876 0720-0963 56.8 µM 0.916211969649629 0.156672881679958 no 499 0.179777864337208 923 765861
SGTC_2959 9079155 11 µM 0.913423924453924 0.15742126719183 no 500 0.180509813790276 831 16189457
SGTC_1079 idarubicin 2.36 µM 0.911876667889223 0.157837604156789 no 501 0.180916822608664 885 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3120 9124077 49.47 µM 0.910858547726758 0.15811195480702 no 502 0.181184954563768 923 18774327 YGL155W CDC43
SGTC_222 nsc-310342 10.666 µM 0.906946480347531 0.15916904149956 no 503 0.182217549966832 847 432556
SGTC_103 0844-0104 51.839 µM 0.904177903018284 0.159919934604872 no 504 0.182950537603884 997 5375804
SGTC_1102 cgs 12066b 26.1 µM 0.90389216372281 0.159997564459498 no 505 0.183026292390815 878 6438352 A 5-HT1B full agonist.
SGTC_3337 9144342 33.5465 µM 0.903230022611818 0.160177550128926 no 506 0.183201913490338 910 17682949
SGTC_1641 st009299 47.1 µM 0.902714185098551 0.160317858694339 no 507 0.18333880298249 865 4046054
SGTC_39 0986-0283 58.349 µM 0.901099012167607 0.160757707457578 no 508 0.183767839053969 972 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1452 4194-0072 190 µM 0.901021259153159 0.160778901253777 no 509 0.183788508242282 986 1343545
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.899357020702569 0.161232974207558 no 510 0.184231262154071 989 1377
SGTC_704 1310-0270 142 µM 0.898409903945281 0.161491759917315 no 511 0.184483529165956 936 5718033
SGTC_2227 7312221 64.1025 µM 0.896420276663769 0.162036277825554 no 512 0.185014170912706 943 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2545 solidagenone 89.61 µM 0.893923588382359 0.162721257161767 no 513 0.185681388003259 705 6708572 An anti ulcer agent
SGTC_1483 3453-0561 55.9 µM 0.892605652649037 0.163083598048492 no 514 0.186034195496818 945 4546991
SGTC_2709 st078560 56 µM 0.889878608439273 0.163835009898812 no 515 0.186765535688515 937 17250903
SGTC_2281 7943571 200 µM 0.889499882107149 0.163939541855287 no 516 0.18686724327067 1016 1244024
SGTC_100 0086-0128 49.5915 µM 0.88714185562955 0.164591352162001 no 517 0.187501265962151 963 93297
SGTC_1606 st000094 49.2 µM 0.885472455190075 0.165053825034997 no 518 0.187950934656889 992 1242210
SGTC_659 k018-0002 107 µM 0.884817775602383 0.165235419913229 no 519 0.188127460354645 947 6797879 YHR007C ERG11
SGTC_2224 6650123 117.647 µM 0.884131948233219 0.165425793180259 no 520 0.188312494341226 913 2908370
SGTC_1662 st014054 52 µM 0.882909372758896 0.165765509793597 no 521 0.1886426195594 915 2838777
SGTC_3340 9146634 11.102 µM 0.882447699957186 0.165893911884354 no 522 0.188767375229379 916 4907387
SGTC_373 0844-0104 25.9 µM 0.882268583232915 0.165943745772201 no 523 0.188815790787251 986 5375804
SGTC_1520 flindersine 88 µM 0.88096201161131 0.166307553008465 no 524 0.18916919079702 966 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_935 2996-0153 430 µM 0.880364634076102 0.166474060751341 no 525 0.189330904389055 934 23738523
SGTC_2481 5478948 45.16 µM 0.87853307085419 0.166985245104683 no 526 0.189827249460751 883 77792
SGTC_1895 st058434 18.3 µM 0.877364493883197 0.167311920197055 no 527 0.190144346056197 976 5393175
SGTC_3235 9132602 49.47 µM 0.876744109908756 0.167485515479836 no 528 0.190312821151888 942 4912240
SGTC_2897 9048598 12.99 µM 0.876055545638551 0.167678324733873 no 529 0.190499919011821 915 6467404
SGTC_2283 7944793 200 µM 0.875784529817777 0.167754252783737 no 530 0.190573590857097 968 2970533
SGTC_1026 k007-1105 30.6 µM 0.87511407764632 0.16794218241411 no 531 0.190755919007586 948 7066794
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.872404638779347 0.168703025510372 no 532 0.191493835392558 1006 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_142 0335-0849 62.6745 µM 0.87097324281498 0.169105871658785 no 533 0.191884381520439 1003 3889043 YPR107C YTH1
SGTC_768 0384-0033 77.3 µM 0.870959850346832 0.169109643694042 no 534 0.191888037860174 931 3965305 YMR134W ERG29
SGTC_2950 9072895 21.46 µM 0.870586167846373 0.169214914456487 no 535 0.191990075846235 975 17332245
SGTC_2605 digitonin 300 nM 0.868858974900078 0.169702031553529 no 536 0.192462135591363 1042 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1366 1683-0113 21.9 µM 0.868061398160836 0.169927273924955 no 537 0.192680360880872 944 708623
SGTC_1473 k844-0725 134 µM 0.86780167764423 0.170000662529896 no 538 0.192751455738308 1051 54682906
SGTC_1954 st077032 68.9 µM 0.867775205240013 0.170008143914588 no 539 0.192758703088544 857 698907
SGTC_2883 9059145 45.46 µM 0.867160068950817 0.170182047437854 no 540 0.192927155833297 917 16476510
SGTC_757 1066-0008 322 µM 0.865807473750039 0.170564836699361 no 541 0.193297874988463 971 6842497
SGTC_1587 estradiol valerate 56.1 µM 0.864530112184577 0.17092684029884 no 542 0.193648372947029 990 13791 A steroid.
SGTC_3338 9144300 39.5675 µM 0.863488478449433 0.171222402340768 no 543 0.193934475717298 945 4901274
SGTC_1131 3454-3128 32.3 µM 0.861811693947729 0.171698873472265 no 544 0.1943955744093 1002 710982
SGTC_3063 1327-0034 4 µM 0.860345485306765 0.172116201278706 no 545 0.194799313343696 934 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2678 equilin 100 µM 0.860202783232437 0.172156853194853 no 546 0.194838635366326 992 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1291 0993-0025 5.79 µM 0.859038881048464 0.172488645852762 no 547 0.195159532640868 973 4353356
SGTC_1728 st035614 33.7865 µM 0.858222456035566 0.172721626671828 no 548 0.195384819206199 985 15945546
SGTC_2581 avocatin a 64 µM 0.857138980888435 0.17303112440626 no 549 0.19568404014599 950 6710728 A skin care supplement.
SGTC_1914 st062367 72.6 µM 0.856416599933694 0.173237670743025 no 550 0.195883692975913 913 978205
SGTC_818 4072-2707 53.5 µM 0.855050906949955 0.173628584465045 no 551 0.19626148301033 967 882871
SGTC_2763 lisinopril 49.32 µM 0.8544089834776 0.173812521341161 no 552 0.196439210055135 940 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1059 3448-6867 171 µM 0.851492045633168 0.174649901629549 no 553 0.197248040041098 990 3934407
SGTC_252 miconazole 1.30953 nM 0.851232953982487 0.174724404060823 no 554 0.197319980173285 948 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2665 lovastatin 100 µM 0.851146593514746 0.174749241705046 no 555 0.197343962795005 967 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1068 loratadine 26.9 µM 0.85110484169564 0.174761250512591 no 556 0.197355558061974 930 3957 A H1 histamine antagonist.
SGTC_2450 5739737 12.93 µM 0.849777950557415 0.175143168536203 no 557 0.197724275336746 924 2262825
SGTC_254 nsc-64875 3.808 µM 0.847260754786222 0.175869144516833 no 558 0.198424898112124 1011 56993
SGTC_2941 9056145 11.23 µM 0.847256013179985 0.175870513823474 no 559 0.198426219277264 892 2119517
SGTC_2251 lansoprazole 556 µM 0.84676023873687 0.176013723504293 no 560 0.198564387390099 806 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_325 2810-4341 181 µM 0.844128720914915 0.176775100742246 no 561 0.199298739977498 998 774970
SGTC_292 k038-0015 474 µM 0.844045217732764 0.176799294755412 no 562 0.199322069154326 980 46368540
SGTC_1151 3909-8316 15.3 µM 0.843284803923415 0.177019711551935 no 563 0.199534589750256 970 800431
SGTC_1147 3809-1045 12.3 µM 0.84168256260303 0.177484712122774 no 564 0.199982830650072 954 325925
SGTC_1839 st053978 48 µM 0.841356837897531 0.17757933777986 no 565 0.200074028956359 990 3788398
SGTC_1775 st081588 35.1725 µM 0.840955437328093 0.177695991671271 no 566 0.200186449815063 1045 1426443 YGL099W LSG1
SGTC_1250 0485-0349 40.2 µM 0.840048475806818 0.17795974824445 no 567 0.200440603644722 958 6842794 YDL195W SEC31
SGTC_822 1487-0950 154 µM 0.837731821336473 0.17863458239854 no 568 0.201090668701439 997 1958375
SGTC_3268 9137683 49.47 µM 0.837509703881612 0.178699369064431 no 569 0.201153062351797 961 1953228
SGTC_368 fentichlor 4.58 µM 0.835839642237467 0.179186962172011 no 570 0.201622560800763 918 7329 A pesticide.
SGTC_1240 0356-0016 42.1 µM 0.835639246557419 0.179245526103276 no 571 0.201678941397462 954 4305613
SGTC_2558 carylophyllene oxide 100 µM 0.831719645643167 0.180393415556581 no 572 0.202783604499195 1081 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_290 2043-6722 48.1 µM 0.83123559048257 0.180535494618576 no 573 0.202920276351979 989 773758 YLR208W SEC13
SGTC_2448 5185112 27.17 µM 0.82923135605933 0.181124520798919 no 574 0.203486752535279 917 5718189
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.828856356807812 0.181234863202098 no 575 0.20359284686878 978 6710655
SGTC_1624 st003710 6.25 µM 0.82849013010503 0.181342664934349 no 576 0.203696491116583 1053 24207033
SGTC_1412 3909-8563 178 µM 0.827879016871139 0.181522640333727 no 577 0.20386950967893 1080 23767530
SGTC_3087 9117406 49.47 µM 0.827496693052407 0.181635293125717 no 578 0.203977797838139 980 42546093
SGTC_641 4092-0595 30 µM 0.826161972391072 0.18202891519109 no 579 0.204356108372217 1007 786260
SGTC_2215 7188065 200 µM 0.823202532916391 0.182903583147484 no 580 0.205196414366035 1013 940217
SGTC_3319 9138450 16.7555 µM 0.816900827737791 0.184774785200761 no 581 0.206992552368494 970 2029690
SGTC_1809 st050081 57.6 µM 0.815322791484516 0.185245217282933 no 582 0.207443783035074 1021 5036894
SGTC_1922 5578187 25 µM 0.814741006750954 0.185418841978345 no 583 0.20761028772379 1001 1350412
SGTC_450 aminopyrene 156 nM 0.813984866197572 0.185644651394009 no 584 0.207826810390632 1013 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1514 1189-1591 158 µM 0.813469632358742 0.185798615530376 no 585 0.207974425208404 1030 767698 YMR146C TIF34
SGTC_841 0251-0215 91.2 µM 0.81312756885025 0.185900875981508 no 586 0.208072460798348 1060 3888614
SGTC_1720 st037298 9.481 µM 0.811599076863709 0.186358247477527 no 587 0.208510860584637 979 597396
SGTC_2293 7624732 200 µM 0.811316798285135 0.186442790047836 no 588 0.208591882844013 1021 894453
SGTC_3016 9080866 49.47 µM 0.808590348425241 0.187260585466465 no 589 0.20937540911305 1065 17066299
SGTC_2462 5162487 171.77 µM 0.808446767476241 0.187303713791161 no 590 0.209416719307889 1048 2259986
SGTC_139 0099-0334 718.624 µM 0.807789339929231 0.187501267918013 no 591 0.209605931411947 1118 97690
SGTC_3328 9140624 29.0385 µM 0.806225560869752 0.18797169392264 no 592 0.210056401448621 1055 4904392
SGTC_130 0136-0219 337.655 µM 0.805725721814366 0.188122212242578 no 593 0.210200507464965 1014 234244
SGTC_589 1227-0070 34.1 µM 0.805259856976856 0.188262566738567 no 594 0.210334870814035 1021 2841384
SGTC_3077 9117319 49.47 µM 0.803128177158579 0.18890561727684 no 595 0.210950326524681 1050 17154678
SGTC_921 1561-0023 372 µM 0.803039355012068 0.188932441035745 no 596 0.210975994027642 1098 24050882
SGTC_2830 7992007 71.43 µM 0.803012341245008 0.188940599497752 no 597 0.210983800731532 979 1952075
SGTC_1855 st056195 39.6 µM 0.800792938744312 0.189611625330652 no 598 0.211625763793609 990 4028379
SGTC_2952 9073731 13.78 µM 0.800293338377346 0.189762879050953 no 599 0.2117704309047 1103 16457353
SGTC_1476 4112-3294 3.34 µM 0.799605767922787 0.189971161896347 no 600 0.211969622294348 1051 704369
SGTC_1317 1273-0028 910 nM 0.797829706054242 0.190509826886443 no 601 0.212484660027562 1041 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2029 5175081 200 µM 0.794857494978769 0.191413369453027 no 602 0.213348200867053 1109 1380876
SGTC_3085 9117376 49.47 µM 0.794828732200112 0.191422126054111 no 603 0.213356567535939 1050 16480349
SGTC_2036 5160441 105 µM 0.794498982332086 0.19152253333817 no 604 0.213452500584129 1080 134534 YIL048W NEO1
SGTC_1381 2324-0066 62.1 µM 0.792904101699842 0.192008622265638 no 605 0.213916848705445 1000 10885928
SGTC_2267 7931562 200 µM 0.790345849255189 0.192789903515033 no 606 0.214662908670924 959 934880
SGTC_860 0443-0016 25.1 µM 0.789484093335117 0.193053517423246 no 607 0.214914561556409 1103 5337942
SGTC_1746 st038117 42 µM 0.788850281028046 0.193247543041366 no 608 0.215099758885582 1023 2898218
SGTC_195 4234-0266 16.654 µM 0.788420237635899 0.193379257703209 no 609 0.215225468524342 1075 2303354
SGTC_1183 1254-0324 198 µM 0.786844609956307 0.193862312333617 no 610 0.215686417801281 1066 5799357
SGTC_3014 9081533 49.47 µM 0.78623250099548 0.194050170376973 no 611 0.215865644292208 1053 21367265
SGTC_621 3584-0052 32.1 µM 0.785231277143779 0.194357687900005 no 612 0.216158990213814 1091 2273927
SGTC_73 0327-0325 16.231 µM 0.785069652368633 0.194407357396155 no 613 0.216206365859194 1115 53298
SGTC_291 SEC14.278 35.5 µM 0.7847002916487 0.194520895984047 no 614 0.216314655877459 1086 1068044
SGTC_310 1273-0058 1.06 µM 0.784668908520709 0.194530544771231 no 615 0.216323858301475 1132 2734232
SGTC_2864 9034755 47.6 µM 0.784630280515556 0.194542421406072 no 616 0.216335185440265 1095 4930451
SGTC_1887 st057648 70.8 µM 0.781403298016491 0.195536152868854 no 617 0.217282666002113 1068 688672
SGTC_537 1334-0398 209 µM 0.780431123692038 0.195836131737751 no 618 0.217568577049938 1079 5846986
SGTC_868 0527-0199 213 µM 0.779594651377482 0.196094461124318 no 619 0.217814752581923 1033 2849450
SGTC_3156 9099931 49.47 µM 0.779344705442962 0.196171692505049 no 620 0.217888343351797 1092 18111053
SGTC_83 0170-0301 39.027 µM 0.778411468478753 0.196460218552947 no 621 0.21816323996222 1024 3089716
SGTC_2617 dihydrotanshinone i 20.83 µM 0.778091184942977 0.196559298889179 no 622 0.218257629529801 1112 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_3172 9105863 49.47 µM 0.777741726866061 0.196667438957215 no 623 0.218360643855342 1051 2348785
SGTC_617 3770-0098 35 µM 0.776656817745696 0.197003394454532 no 624 0.218680635087328 1035 5962639
SGTC_2793 7325131 81.82 µM 0.776071638917685 0.197184746423677 no 625 0.2188533441125 1036 4176441
SGTC_1842 st055362 61.2 µM 0.775797422344938 0.197269763251258 no 626 0.218934303081705 1089 676032
SGTC_2291 7917025 104.35 µM 0.771416441556541 0.198631027079496 no 627 0.220230066361436 1049 2964612
SGTC_2621 lithochol-11-enic acid 100 µM 0.77134344236028 0.19865375736014 no 628 0.220251694526214 1097 6708711
SGTC_2616 abietic acid 100 µM 0.771059489432486 0.198742188726487 no 629 0.220335835537077 1095 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3343 9148379 18.9835 µM 0.770908883141779 0.198789101625177 no 630 0.220380470712917 1117 1955036
SGTC_220 paclitaxel 373.376 µM 0.769547652803395 0.199213418977447 no 631 0.220784133511854 1012 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3170 9103054 49.47 µM 0.767433918733122 0.19987338401931 no 632 0.221411784154789 1053 16432970
SGTC_1930 st074634 34.3 µM 0.763933912192183 0.200969067800852 no 633 0.222453313506793 1106 684253 YOR116C RPO31
SGTC_1246 0422-0085 105 µM 0.761862655182888 0.201619172607046 no 634 0.223070990372246 1107 264295
SGTC_2781 5567276 71.43 µM 0.76060115153262 0.20201573693595 no 635 0.223447665880211 1068 2853274
SGTC_225 nsc-122657 1.016 µM 0.760473598092925 0.20205586040859 no 636 0.22348577251197 998 275685
SGTC_2734 clemastine 41.6 µM 0.760025397452732 0.202196885141622 no 637 0.223619701913058 1036 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_65 0798-0905 34.986 µM 0.759682983017144 0.202304664290395 no 638 0.223722051479178 1141 3602145
SGTC_2006 4011487 200 µM 0.759319743767467 0.202419035857457 no 639 0.223830654802785 1115 45595294
SGTC_3303 9125618 40.5795 µM 0.75924684495068 0.202441993849189 no 640 0.223852454112709 1128 22695467
SGTC_1305 1181-0477 144 µM 0.758401439720397 0.202708350645293 no 641 0.224105348128118 1087 6252086
SGTC_458 nppb 133 µM 0.757092194150958 0.203121259899898 no 642 0.224497315133461 1084 4549 A chloride channel blocker.
SGTC_2136 5328288 199.296 µM 0.756300341914221 0.203371237393747 no 643 0.224734571587162 1026 262395
SGTC_3110 9122132 49.47 µM 0.755847324452382 0.203514331647787 no 644 0.224870369563654 1138 918317
SGTC_255 tunicamycin 200.472 nM 0.755804772444759 0.203527775600218 no 645 0.224883127480342 1093 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_23 0213-0011 39.996 µM 0.755738627493132 0.203548674598462 no 646 0.22490295983358 1092 627608
SGTC_2310 7668677 200 µM 0.755004220657979 0.203780801984095 no 647 0.225123224886984 1106 2197143
SGTC_1860 st056228 74.6 µM 0.752631102574787 0.204531962512637 no 648 0.225835811059235 1112 688679
SGTC_2365 9042475 200 µM 0.750992402938052 0.205051618757731 no 649 0.226328613943114 1133 6464479
SGTC_3307 9126885 69.2785 µM 0.749630156591211 0.205484204262433 no 650 0.226738741516739 1105 24824909
SGTC_517 1365-0151 113 µM 0.747182844252885 0.206262715659499 no 651 0.227476599158541 1111 768657
SGTC_1981 st071826 47 µM 0.746274766981857 0.206552027070778 no 652 0.227750725464892 1083 11838600
SGTC_1709 st033179 39.1045 µM 0.745737423436863 0.206723336677727 no 653 0.227913023854631 1123 573381
SGTC_2757 clomiphene 4.22 µM 0.745516901906123 0.206793665121604 no 654 0.227979648653807 1177 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1666 st014829 29 µM 0.74455548316743 0.207100445001203 no 655 0.228270244085828 1151 3858230
SGTC_2601 securinine 100 µM 0.744048626309421 0.207262286690823 no 656 0.228423528838477 1109 442872 A GABA receptor antagonist.
SGTC_2321 7390090 138.78 µM 0.74401634818089 0.207272595775904 no 657 0.22843329241872 1071 649046
SGTC_3152 9099253 49.47 µM 0.742620508603328 0.207718693199444 no 658 0.228855734202911 1154 25236131
SGTC_1176 0848-0131 83.3 µM 0.740810683508256 0.208297940199554 no 659 0.229404118262267 1193 6769040
SGTC_2403 6032726 181.2 µM 0.739975443089091 0.208565585706311 no 660 0.229657447536096 1121 2881040
SGTC_3049 9092223 49.47 µM 0.739730139971525 0.208644229452048 no 661 0.229731877979931 1071 8623917
SGTC_573 3702-0553 84.7 µM 0.739557980954218 0.208699433765996 no 662 0.229784122936808 1109 1222756
SGTC_2233 sulbentine 40.3845 µM 0.739219254524346 0.208808074524836 no 663 0.229886935390512 1140 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_523 1934-0222 13.7 µM 0.739091443891009 0.208849076276017 no 664 0.229925735997588 1145 1361595
SGTC_2789 5281112 71.43 µM 0.738034467645744 0.209188336865021 no 665 0.230246752116871 1121 765948
SGTC_577 r071-0003 38.6 µM 0.73719943669561 0.209456588321234 no 666 0.230500537981721 1192 4568517 YMR134W ERG29
SGTC_1605 st000082 49.1 µM 0.736523471602739 0.20967388845234 no 667 0.23070609439095 1134 1114022
SGTC_852 0418-0143 439 µM 0.735226015773756 0.210091348267397 no 668 0.231100928692334 1181 5369229
SGTC_1849 st056239 19.2 µM 0.735139167292387 0.210119309419484 no 669 0.2311273713824 1101 5393181
SGTC_1133 3473-0247 50 µM 0.733120396195045 0.210769875134464 no 670 0.231742500601377 1110 711311
SGTC_620 0109-0052 432 µM 0.7327272348556 0.210896711946786 no 671 0.231862404774289 1153 493037
SGTC_3236 9132701 49.47 µM 0.72994885578178 0.211794312853767 no 672 0.232710723667642 1133 24282524
SGTC_2003 4023581 200 µM 0.729728113820656 0.211865722891009 no 673 0.232778196415541 1135 16641307
SGTC_2296 7971656 126.45 µM 0.729634720751769 0.21189593979423 no 674 0.232806746534843 1156 666570
SGTC_2385 9074692 200 µM 0.72955711766393 0.21192104983847 no 675 0.232830471160885 1153 17046906
SGTC_1512 0259-0544 12.2 µM 0.728040609148681 0.212412096014211 no 676 0.233294363952231 1151 18476
SGTC_223 busulfan 5 mM 0.727996558654529 0.212426369513859 no 677 0.233307846451686 1098 2478 A DNA alkylator.
SGTC_3245 9134821 49.47 µM 0.727916654704567 0.212452261890809 no 678 0.233332303693088 1129 17014901
SGTC_1054 3429-0080 167 µM 0.727189927574596 0.212687837918302 no 679 0.233554807815861 1163 1162877
SGTC_848 0368-0089 85.6 µM 0.725061377201632 0.213378706272556 no 680 0.234207188717919 1147 762535
SGTC_3311 9131146 2.8755 µM 0.724044047057275 0.213709364901137 no 681 0.234519346914326 1102 4900406 YPR165W RHO1
SGTC_3102 9121669 49.47 µM 0.722396831573174 0.214245384964847 no 682 0.23502526717379 1162 41905072
SGTC_1494 4358-1428 177 µM 0.721911474587396 0.214403473938783 no 683 0.23517445302094 1202 1564571
SGTC_2019 4016004 108 µM 0.721832276412437 0.214429276559214 no 684 0.235198801398551 1133 45595336
SGTC_1286 0929-0070 131 µM 0.718191400500817 0.215617415510937 no 685 0.236319639785223 1191 1420408
SGTC_1256 0570-0116 285 µM 0.718092429289344 0.215649766315403 no 686 0.236350148933321 1164 410638
SGTC_480 am 92016 50 µM 0.714891713209938 0.216697503356789 no 687 0.23733797896828 1105 2129 K+ channel blocker.
SGTC_1570 verbenone 133 µM 0.713859445084032 0.21703603754991 no 688 0.237657048464401 1176 29025 A natural terpanoid with antifungal properties.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.71371201170573 0.217084413522317 no 689 0.237702638666835 1185 364106
SGTC_135 0933-0004 26.348 µM 0.712527309151413 0.217473365300552 no 690 0.238069153365513 1133 21230617 YGL099W LSG1
SGTC_529 4076-0302 30.3 µM 0.712052160763146 0.217629475061986 no 691 0.238216238311024 1115 5816522
SGTC_85 0868-0259 160.055 µM 0.712019792141713 0.217640112108226 no 692 0.238226260016918 1102 83173
SGTC_2702 st077768 96.8 µM 0.71195479845998 0.217661471378141 no 693 0.238246383522695 1106 6484119
SGTC_2339 9000433 200 µM 0.711509295849215 0.217807912173965 no 694 0.238384346216855 1146 2988954
SGTC_1691 st019933 84.6 µM 0.711403770444392 0.217842607665677 no 695 0.238417031600519 1154 6176082
SGTC_1325 1431-0015 227 µM 0.711085843395272 0.21794715754574 no 696 0.238515520990674 1125 1103340
SGTC_788 1182-0090 188 µM 0.710839285388188 0.218028257728345 no 697 0.238591916572898 1225 5715185
SGTC_2363 9053361 176 µM 0.710386494869241 0.218177239154767 no 698 0.238732247824499 1195 6469797 YMR079W SEC14
SGTC_2012 4023501 200 µM 0.709466633777072 0.218480081153268 no 699 0.239017475082158 1147 3477460
SGTC_343 4130-2827 29.8 µM 0.709387714215995 0.218506074778832 no 700 0.239041954853784 1195 1118244
SGTC_176 1486-1328 72.834 µM 0.707004321908876 0.219291927952252 no 701 0.239781895991772 1181 22310231
SGTC_2731 amoxapine 43.43 µM 0.705637195097755 0.219743429742605 no 702 0.240206893590665 1204 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1437 4092-1038 11.6 µM 0.705470345482131 0.219798569341915 no 703 0.24025879008837 1186 3977136
SGTC_1604 st002052 72.4 µM 0.702153721562541 0.220896276957084 no 704 0.241291651396719 1218 6254834 YHR062C RPP1
SGTC_261 5-fluorouridine 15.376 µM 0.70146987054687 0.221123001720471 no 705 0.241504915568195 1204 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.700820265569364 0.221338495773395 no 706 0.241707594620719 1233 6708561
SGTC_1885 st057546 99.9 µM 0.700313213794553 0.221506783946965 no 707 0.241865860706108 1222 702008
SGTC_2733 amorolfine 100 µM 0.699445497386074 0.221794944686492 no 708 0.242136831444201 1192 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_356 1634-0012 32.5 µM 0.699141857247379 0.221895831374388 no 709 0.242231691137495 1200 735457
SGTC_2811 7967822 32.47 µM 0.698337469731706 0.222163221728986 no 710 0.242483085791758 1188 2232244
SGTC_2094 5332512 191.667 µM 0.697570235222056 0.222418433133184 no 711 0.24272300066557 1217 755774
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.69604901628739 0.222924942590689 no 712 0.243199066814581 1201 5282362
SGTC_2942 9052777 62.25 µM 0.695946145873836 0.222959218323906 no 713 0.24323127836914 1272 6469503
SGTC_2208 7283366 200 µM 0.695364924479697 0.223152933786196 no 714 0.243413318086228 1207 898663
SGTC_504 lovastatin 124 µM 0.693834729476834 0.22366339092008 no 715 0.243892930072756 1163 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1006 4099-6547 255 µM 0.691070270085272 0.224587266958056 no 716 0.244760691171784 1203 3146833
SGTC_3079 9117512 49.47 µM 0.690563017633039 0.224757024337239 no 717 0.244920097498524 1232 7185044
SGTC_2769 toremifene 3.73 µM 0.690485512551702 0.224782968636232 no 718 0.244944458732227 1220 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_664 1222-0054 14.9 µM 0.690447142987101 0.224795813215508 no 719 0.244956519455335 1212 6813991
SGTC_720 r052-1644 49.9 µM 0.689931567132859 0.224968447533109 no 720 0.245118611642124 1189 1422863 YOR257W CDC31
SGTC_32 0928-0142 34.1 µM 0.689405951560837 0.225144520851949 no 721 0.245283919585143 1178 2244242
SGTC_505 gw-5074 63.9 µM 0.688072587102822 0.225591527950918 no 722 0.245703536099014 1205 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1042 0350-0096 82 µM 0.687858946166089 0.225663197193484 no 723 0.245770805788619 1206 3122515
SGTC_3252 9135871 49.47 µM 0.686828223750457 0.226009150332278 no 724 0.246095490973616 1245 17682838
SGTC_2255 7941087 197.44 µM 0.685675876754679 0.226396280442815 no 725 0.246458761027149 1231 935561
SGTC_1024 4507-0395 26 µM 0.684188178552465 0.226896624918933 no 726 0.246928173028405 1247 4201836
SGTC_1185 1319-0113 81.3 µM 0.683456089912322 0.227143070662987 no 727 0.247159343797833 1223 4672763
SGTC_1367 1812-0510 76.9 µM 0.683325406442252 0.227187078995727 no 728 0.247200621735049 1202 1142582 YDR527W RBA50
SGTC_982 1491-0518 27.5 µM 0.682754969155533 0.227379232957555 no 729 0.247380844333853 1183 3091256
SGTC_2487 5918373 44.05 µM 0.682008833903822 0.227630709592479 no 730 0.247616682494771 1254 2876279
SGTC_44 0929-0055 61.211 µM 0.681891017794103 0.227670432519264 no 731 0.247653932743888 1183 1379590
SGTC_691 1548-0686 185 µM 0.681775242128107 0.227709471290467 no 732 0.247690540775628 1192 46495133
SGTC_924 2046-0044 21.3 µM 0.681744631795431 0.227719793517313 no 733 0.247700220184012 1236 3623589
SGTC_3105 9121040 49.47 µM 0.68031246454858 0.228203034425788 no 734 0.248153316903933 1087 41448907
SGTC_1909 st060837 51.5 µM 0.679806960350837 0.228373738870872 no 735 0.248313349448387 1186 678937
SGTC_186 3455-3465 67.277 µM 0.678743454801506 0.228733109785912 no 736 0.248650213651229 1175 755278
SGTC_899 1083-0020 478 µM 0.67782964136946 0.229042151437132 no 737 0.24893985735371 1257 767123
SGTC_3264 9137442 49.47 µM 0.677515527345275 0.229148435419009 no 738 0.249039460868509 1262 17015726
SGTC_3178 9107506 49.47 µM 0.677147912695643 0.229272857055722 no 739 0.24915605600664 1253 8897194
SGTC_1679 SEC14.276 6.7 µM 0.67678453937229 0.22939588040346 no 740 0.249271334464354 1254 1005053 YMR079W SEC14
SGTC_421 streptovitacin 30 mM 0.676711438685099 0.229420633776429 no 741 0.249294528735476 1243 91467 include heat shock
SGTC_985 1493-0307 8.71 µM 0.674735857246674 0.23009017231623 no 742 0.249921799436435 1215 3278274
SGTC_1516 st013856 110 µM 0.674490759476595 0.230173313850344 no 743 0.249999679274407 1216 5281404 A mutagen and neurotoxin.
SGTC_1976 st070609 63.5 µM 0.673673927801472 0.230450519017456 no 744 0.250259320556536 1183 682556
SGTC_1322 1348-1070 12 µM 0.670513590234016 0.231524787109366 no 745 0.251265222982816 1214 6758089
SGTC_1941 st076221 61.8 µM 0.670486679419533 0.231533946657013 no 746 0.251273797583997 1233 2828568
SGTC_1644 st010134 20.9 µM 0.668991053473248 0.232043325542409 no 747 0.251750592490083 1227 3818134
SGTC_3212 9128307 49.47 µM 0.66781047812254 0.232445844998721 no 748 0.252127288614645 1189 27243542
SGTC_3052 9092717 49.47 µM 0.665915469524291 0.233092763031256 no 749 0.252732566051129 1239 25237534
SGTC_2348 9022543 33.42 µM 0.664439204423806 0.233597422339283 no 750 0.253204623913463 1249 3162678 YDL140C RPO21
SGTC_1886 st057356 49.9 µM 0.664043562342297 0.233732774943389 no 751 0.253331215129465 1209 24207747
SGTC_171 k064-0041 9.68 µM 0.663994204770473 0.233749663648324 no 752 0.253347010108597 1203 53325
SGTC_490 phenamil 164 µM 0.663123019364826 0.234047868900472 no 753 0.253625884439294 1187 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2655 perillic acid 100 µM 0.660602313236249 0.234911887926272 no 754 0.254433692574995 1227 5702197 An apoptosis inducer.
SGTC_75 0159-0059 199.013 µM 0.660343054300651 0.23500085362105 no 755 0.254516853425963 1353 5377270
SGTC_1654 st012436 41.8 µM 0.659744093265773 0.235206460553279 no 756 0.254709032813213 1216 4323132
SGTC_493 zm226600 134 µM 0.659455734756511 0.23530548155035 no 757 0.254801581048518 1277 5240098 A potassium channel opener. YCR052W RSC6
SGTC_110 0850-0284 111.64 µM 0.659421234510668 0.235317330318691 no 758 0.254812655030144 1128 3906265
SGTC_3106 9121286 49.47 µM 0.659126307131645 0.235418633652651 no 759 0.254907331894478 1273 15943471
SGTC_1028 k015-0029 4.8 µM 0.657807060153462 0.235872070600325 no 760 0.255331058572775 1254 4588309
SGTC_2524 avocatin b 10.57 µM 0.657248587571028 0.236064167547272 no 761 0.255510544277566 1195 6710748
SGTC_1104 tacrolimus 29.8 µM 0.654822386210903 0.236899704069347 no 762 0.256291057853729 1302 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1802 st050112 57.9 µM 0.654699225484663 0.236942161543006 no 763 0.256330712012506 1250 4662563
SGTC_1177 0983-0204 23.6 µM 0.653720029832958 0.237279870642862 no 764 0.256646098173701 1280 766818
SGTC_56 0957-0365 83.25 µM 0.652902654762062 0.23756197269397 no 765 0.256909518687871 1226 6752360
SGTC_3186 9110464 49.47 µM 0.652458712512655 0.237715268339568 no 766 0.257052649632755 1279 17018021
SGTC_2102 5377816 72.7585 µM 0.652328937275826 0.23776009067466 no 767 0.257094498160695 1281 1379702
SGTC_1793 st048256 72.231 µM 0.652179426124475 0.23781173523204 no 768 0.257142715306915 1194 672022
SGTC_1253 0550-0034 176 µM 0.649023456700918 0.238903313312395 no 769 0.258161607369975 1249 5969915
SGTC_3047 9092122 49.47 µM 0.648655863617606 0.239030633323912 no 770 0.258280419271815 1233 17173831
SGTC_1884 5633444 25 µM 0.648107381690958 0.239220675173284 no 771 0.258457749984753 1289 5724239
SGTC_2256 7954252 200 µM 0.647009276561725 0.239601402289603 no 772 0.258812969839315 1224 2972920
SGTC_1091 telmisartan 47.6 µM 0.646841516731148 0.239659595883095 no 773 0.258867259761163 1334 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_693 4161-2696 114 µM 0.646246722888788 0.239865983886739 no 774 0.25905979258851 1309 805759
SGTC_369 0957-0393 4.5 µM 0.646128869138886 0.239906889561192 no 775 0.259097950250678 1248 6997992
SGTC_2787 5284540 71.43 µM 0.644241479292376 0.240562498846326 no 776 0.259709428598132 1298 736958
SGTC_1630 st005209 31.3 µM 0.644089670342454 0.240615274001994 no 777 0.259758644148808 1278 3367314
SGTC_1716 st033144 30.6155 µM 0.64333731424276 0.240876917522775 no 778 0.260002624494498 1294 674617
SGTC_718 1130-0073 349 µM 0.641673467574607 0.241456095271334 no 779 0.260542609991062 1348 6740020
SGTC_190 3970-0790 3.722 µM 0.641475388963217 0.24152509591949 no 780 0.260606932946414 1278 2832352
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.641071640674582 0.241665774714643 no 781 0.260738069246143 1247 17037758
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.639749850849362 0.24212663951787 no 782 0.261167620250631 1258 15053
SGTC_1663 st014140 55.4 µM 0.638893291335717 0.242425548020943 no 783 0.261446176277591 1354 4207120
SGTC_153 4077-0274 519.67 µM 0.638582893843668 0.242533914923082 no 784 0.261547156229126 1391 3121976
SGTC_2483 5729050 27.16 µM 0.637810611393033 0.242803650288915 no 785 0.261798485585646 1341 2865180
SGTC_2694 st077685 81.9 µM 0.637176737126681 0.243025165037515 no 786 0.262004864316728 1252 2838096
SGTC_2275 7947463 200 µM 0.635483870663725 0.243617292345992 no 787 0.262556441494764 1246 1225414
SGTC_3019 9081971 49.47 µM 0.634792772757896 0.243859246893311 no 788 0.262781788759669 1336 16451803
SGTC_735 3076-0345 636 µM 0.634766496758198 0.243868448723646 no 789 0.262790358563464 1334 2888990
SGTC_1829 berberine 14.4 µM 0.634622656619828 0.243918824724844 no 790 0.262837273936083 1348 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.632917062426545 0.244516589370517 no 791 0.263393902466585 1284 16486 A toxic proline analog.
SGTC_61 0978-8327 98.565 µM 0.632539865012744 0.244648893344239 no 792 0.263517083797307 1304 6150059 YHR072W ERG7
SGTC_1297 1068-0111 14.1 µM 0.632408574764001 0.244694953131086 no 793 0.263559966140409 1244 767057
SGTC_63 0099-0242 26.702 µM 0.632022016267653 0.24483059428555 no 794 0.263686245498263 1285 3898502 YLR359W ADE13
SGTC_286 k060-0067 22.9 µM 0.63131979343237 0.245077103741898 no 795 0.263915723729331 1260 5985051
SGTC_2308 7584454 197.62 µM 0.631249461778123 0.245101800434161 no 796 0.263938712900754 1358 893577
SGTC_2497 7-hydroxyflavone 100 µM 0.629620387281284 0.245674218123698 no 797 0.264471490802321 1310 5281894
SGTC_3271 9137798 49.47 µM 0.62876643632752 0.245974562539249 no 798 0.26475098821474 1247 6498326
SGTC_1194 1488-0194 225 µM 0.628282863700913 0.246144727949286 no 799 0.26490932769809 1303 1391452
SGTC_1701 st028638 40.4 µM 0.626932995956568 0.246620069717922 no 800 0.265351578640273 1311 3490878
SGTC_164 4100-3994 89.624 µM 0.626014876432959 0.246943656594557 no 801 0.26565259187448 1337 4615967
SGTC_1499 4480-0877 67.3 µM 0.624828461217821 0.247362139285344 no 802 0.266041824399036 1243 2861909
SGTC_648 0375-0473 33.3 µM 0.622979506794042 0.248015073541777 no 803 0.266648994431451 1315 1713139
SGTC_930 2810-3379 265 µM 0.622625176403223 0.248140305636863 no 804 0.266765431375132 1435 1015764
SGTC_306 1672-3436 11.6 µM 0.622304285400284 0.248253748241746 no 805 0.266870901929065 1328 6797378
SGTC_808 0711-0032 135 µM 0.622088321558559 0.248330112164148 no 806 0.266941896850104 1287 4252555
SGTC_443 clozapine 122 µM 0.621810542766942 0.248428352006302 no 807 0.267033226546832 1237 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_366 0181-0206 4.31 µM 0.621190799213127 0.248647606473003 no 808 0.267237046227476 1347 274874
SGTC_2124 5246320 200 µM 0.620664501778053 0.248833882228611 no 809 0.267410195211802 1321 579342
SGTC_224 benfluorex 43.875 µM 0.620099786815756 0.249033837933091 no 810 0.267596046265897 1319 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1706 st031321 9.9705 µM 0.61920032625257 0.24935249764872 no 811 0.267892198480046 1339 6103185
SGTC_919 tnp00227 403.569 nM 0.619082431841938 0.249394281188264 no 812 0.267931028080013 1331 1269246 A methoxyflavone. YNL221C POP1
SGTC_2236 dapsone 200 µM 0.618691487520249 0.249532864321087 no 813 0.268059809439473 1310 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1908 st060353 56.5 µM 0.617652391812826 0.249901404939991 no 814 0.268402250400849 1370 4227716
SGTC_2479 5617353 43.85 µM 0.617098500115801 0.250097974112192 no 815 0.268584878969938 1364 2731746
SGTC_94 0334-0113 514.748 µM 0.616978458272497 0.250140586259178 no 816 0.268624467269153 1263 6795178
SGTC_1334 1486-0610 236 µM 0.616087388375684 0.250457016329409 no 817 0.268918422622226 1319 3742339
SGTC_20 0481-0013 4.944 µM 0.614051544184675 0.251180765324665 no 818 0.269590633423021 1295 182045
SGTC_2656 pseudo-anisatin 100 µM 0.61323756498301 0.251470446717005 no 819 0.269859634785561 1327 6708809 A neurotoxin.
SGTC_749 1000-0129 128 µM 0.612595850449497 0.251698946430844 no 820 0.270071801332228 1404 708470
SGTC_1018 4259-0013 28.1 µM 0.6120080045055 0.251908360975651 no 821 0.270266230816028 1337 6801262
SGTC_1831 st055328 12 µM 0.611805856700121 0.251980395458221 no 822 0.270333107177235 1336 1103068
SGTC_661 1304-0007 33.6 µM 0.611600004775061 0.252053761056457 no 823 0.270401217468926 1326 3117130
SGTC_257 daunorubicin 18.5 µM 0.611414374343182 0.25211992937948 no 824 0.270462644422138 1399 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2090 5301565 104.445 µM 0.608949213534629 0.252999508737333 no 825 0.271279051187822 1353 2056344
SGTC_1628 st004252 77.7 µM 0.607836471049267 0.253397068020782 no 826 0.27164796884346 1373 692968
SGTC_2589 lobaric acid 100 µM 0.607735646907908 0.253433106563885 no 827 0.271681408327021 1308 73157 A novel microtubule depolymerizer.
SGTC_281 1672-3440 14.9 µM 0.607530788257191 0.2535063394586 no 828 0.2717493583606 1327 6833000
SGTC_551 k048-0028 34.9 µM 0.607514595752907 0.253512128431076 no 829 0.271754729650007 1355 6836383
SGTC_12 0849-0099 9.267 µM 0.606228013851015 0.253972315469842 no 830 0.272181676411534 1307 6071388
SGTC_632 0781-2353 4.65 µM 0.606167390583249 0.253994010123065 no 831 0.272201802208344 1367 6811515 YHR007C ERG11
SGTC_548 1436-0017 110 µM 0.605933562295199 0.254077697062495 no 832 0.272279435776236 1401 9677137
SGTC_1844 rapamycin 4 nM 0.604340224015767 0.254648336299329 no 833 0.27280873436418 1290 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1859 st055998 20 µM 0.603990463759803 0.254773689452354 no 834 0.272924991162043 1380 676301
SGTC_2568 diosmetin 100 µM 0.603977568617754 0.254778311654649 no 835 0.272929277847339 1333 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.602886460252332 0.255169573214661 no 836 0.273292111925504 1331 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1769 st044406 64.4 µM 0.602120760853157 0.25544433357704 no 837 0.27354687801149 1344 670903
SGTC_3060 1327-0027 12.5 µM 0.598963279263456 0.256578982081923 no 838 0.274598686010117 1266 16000455 YPR107C YTH1
SGTC_2286 7945697 125 µM 0.59766635602581 0.257045793903236 no 839 0.275031289296071 1298 1245733
SGTC_2079 5212404 121 µM 0.597218175220518 0.257207213803445 no 840 0.275180863043535 1378 758462
SGTC_680 0417-1641 114 µM 0.595144139277892 0.257954898608901 no 841 0.275873563098153 1333 2835990
SGTC_883 0850-0245 24.6 µM 0.594849450534153 0.258061224578271 no 842 0.275972054629158 1424 6823229 YPR165W RHO1
SGTC_780 0109-0199 192 µM 0.59336767710911 0.258596204114821 no 843 0.276467557835355 1441 610414
SGTC_1311 1190-0148 100 µM 0.593250784949404 0.258638431289447 no 844 0.276506664986439 1390 1961333
SGTC_2349 9023730 187.07 µM 0.592966902437258 0.258740998421327 no 845 0.276601651306069 1411 4126287
SGTC_151 3013-0144 2.285 µM 0.592049358008755 0.25907265238034 no 846 0.276908768527672 1410 906558 YHR107C CDC12
SGTC_540 1187-0821 17.3 µM 0.590553642650626 0.259613761812253 no 847 0.27740976674649 1340 847520
SGTC_1226 3909-7979 35.4 µM 0.590214536365626 0.259736522398059 no 848 0.277523413883696 1393 6615510
SGTC_1320 1313-0481 95.3 µM 0.589820742722953 0.259879118055104 no 849 0.277655417336207 1367 6813365 YLR208W SEC13
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.58792617999222 0.260565717638177 no 850 0.278290921558268 1395 688761
SGTC_3259 9138485 49.47 µM 0.587652995499105 0.260664798131315 no 851 0.27838261588695 1460 17646153
SGTC_640 3381-0960 37.1 µM 0.587471396114663 0.260730672614145 no 852 0.278443577835511 1425 1745025
SGTC_2785 7756463 72.73 µM 0.587164679227855 0.260841952442568 no 853 0.278546555833622 1311 2201551
SGTC_50 0929-0078 56.389 µM 0.586998745788824 0.260902164868206 no 854 0.278602274529055 1375 1377751
SGTC_1690 st023502 41.2 µM 0.586942490943464 0.260922579740194 no 855 0.278621165543643 1386 24207482
SGTC_67 0335-0847 266 µM 0.584811482786242 0.261696526719574 no 856 0.279337241238634 1576 4552207 YOR254C SEC63
SGTC_76 0433-0009 400.328 µM 0.584654241982338 0.261753680613388 no 857 0.2793901137526 1369 2841569
SGTC_2776 terbinafine 19.92 µM 0.584575718084817 0.261782224880157 no 858 0.279416519379687 1352 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3149 9097855 49.47 µM 0.583961398270415 0.262005591725156 no 859 0.279623141629354 1424 25236625 YMR079W SEC14
SGTC_2722 naftopidil 47.16 µM 0.580069844637325 0.263422827970748 no 860 0.280933759164696 1383 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.579770647711652 0.263531952080286 no 861 0.2810346470334 1564 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_950 1165-0508 94.1 µM 0.57829957240443 0.264068822967938 no 862 0.281530941528864 1339 6148369
SGTC_2149 5554786 194.827 µM 0.578150393039053 0.264123297279924 no 863 0.281581293550866 1370 745063 YPR165W RHO1
SGTC_460 trequinsin 123 µM 0.577426481804914 0.264387721851282 no 864 0.281825694593438 1405 5537 A vasodilator.
SGTC_958 1222-0007 33 µM 0.576594803636334 0.264691676923735 no 865 0.282106605161637 1459 7312461
SGTC_2871 9038510 12.99 µM 0.575672881819201 0.265028821082324 no 866 0.28241815420353 1468 4945164
SGTC_2400 5203494 178.7 µM 0.575013411343416 0.265270121316239 no 867 0.282641113402419 1337 6777674
SGTC_701 4424-0219 185 µM 0.573963909578427 0.265654363845078 no 868 0.282996111931684 1414 2911779
SGTC_830 4076-0286 57.8 µM 0.57368912179501 0.265755015473382 no 869 0.283089095438626 1417 6866659
SGTC_2669 eugenol 100 µM 0.571450880305773 0.26657557717548 no 870 0.283847023829871 1388 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2872 9044037 25.97 µM 0.569348468795345 0.267347507462495 no 871 0.284559840135499 1403 6465195
SGTC_653 0203-0016 55.2 µM 0.568940485519268 0.267497434870099 no 872 0.284698264618485 1418 295302
SGTC_101 0490-5701 117.494 µM 0.568894953075355 0.267514169953352 no 873 0.284713715296795 1319 4661669
SGTC_2732 terfenadine 20 µM 0.566771485218927 0.268295219420718 no 874 0.285434723034892 1389 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1448 4255-0083 152 µM 0.56670767307562 0.268318708410668 no 875 0.285456403423423 1513 5399660
SGTC_3030 9087619 49.47 µM 0.566020223009761 0.268571821557731 no 876 0.285690016584133 1347 25236973
SGTC_1714 st033236 13.627 µM 0.5658655237869 0.268628797005949 no 877 0.28574259988168 1472 2916566
SGTC_1430 4049-0248 69.1 µM 0.565588042098825 0.268731008233467 no 878 0.285836929290947 1459 22774488
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.565415599759573 0.26879453773804 no 879 0.285895558218944 1428 5024745
SGTC_803 4488-1585 147 µM 0.565004135948497 0.268946155641711 no 880 0.286035475505397 1359 747204
SGTC_3314 9135860 59.4275 µM 0.564989939326175 0.268951387638553 no 881 0.286040303613589 1376 25252478
SGTC_2775 cyproheptadine 69.59 µM 0.564105557465513 0.26927741679267 no 882 0.286341148048294 1391 2913 A selective serotonin reuptake inhibitor.
SGTC_2305 7443522 69.23 µM 0.563816042185495 0.269384190232564 no 883 0.286439666479438 1385 5415886
SGTC_1982 st072467 71.9 µM 0.562794035524177 0.26976127665219 no 884 0.286787571127479 1377 3163533
SGTC_1383 3049-0032 20.7 µM 0.562613599475505 0.269827878988404 no 885 0.286849014752419 1462 712864
SGTC_1713 st033146 12.748 µM 0.562200690808168 0.269980322307397 no 886 0.286989645407706 1467 674619
SGTC_2546 rhodinyl acetate 100 µM 0.56217323473655 0.269990460446804 no 887 0.286998997702148 1394 6708682
SGTC_2058 5236698 133 µM 0.561357791095566 0.270291649390892 no 888 0.287276826061882 1396 766665
SGTC_879 0831-1030 162 µM 0.560739088645102 0.270520282834764 no 889 0.287487707958083 1391 1549252
SGTC_2007 4011539 71.82 µM 0.558984067456401 0.271169353410341 no 890 0.288086296883569 1402 45595301
SGTC_2695 st077686 51.995 µM 0.557619478610907 0.271674563959196 no 891 0.288552126263065 1357 2876092
SGTC_79 0052-0007 94.094 µM 0.557076531282618 0.271875709108497 no 892 0.288737570712444 1456 2801472
SGTC_1821 st053465 65.6 µM 0.555603304171893 0.272421867070106 no 893 0.289241036086519 1361 675086
SGTC_2868 9035608 32.47 µM 0.555417693697251 0.272490715621164 no 894 0.289304496465874 1375 6462614
SGTC_3213 9129884 49.47 µM 0.555232429012748 0.272559444523029 no 895 0.289367845143568 1311 17190742
SGTC_2898 9056270 58.44 µM 0.554916684369763 0.272676598292443 no 896 0.289475824641729 1362 19154699
SGTC_520 3584-0023 682 µM 0.554838256661466 0.272705701952879 no 897 0.289502648567719 1369 1340790
SGTC_3167 9103034 49.47 µM 0.552204264619166 0.273684041717779 no 898 0.290404206438487 1414 5127859
SGTC_2049 5262831 67.185 µM 0.551283607755272 0.274026408980458 no 899 0.29071963686972 1423 763417
SGTC_2918 7977171 22.06 µM 0.549964645005566 0.274517263885398 no 900 0.291171811684314 1365 2236483
SGTC_2625 euphol 100 µM 0.547945940941205 0.275269368186121 no 901 0.291864511281518 1496 6708538 A triterpene alcohol.
SGTC_1496 4469-0713 57.4 µM 0.547573355933822 0.275408292188976 no 902 0.291992444240152 1453 746691
SGTC_1329 1447-1697 50.6 µM 0.546440878018561 0.275830765510339 no 903 0.292381458652485 1404 2840515
SGTC_18 0111-0177 500 nM 0.545190013470718 0.276297773016665 no 904 0.292811419606572 1449 721752
SGTC_1455 4262-0120 131 µM 0.544953025206653 0.276386295750893 no 905 0.292892912890067 1489 1529587
SGTC_1994 st072947 40.9 µM 0.542639913614643 0.277251047057684 no 906 0.293688876060404 1444 5286565 YDL195W SEC31
SGTC_964 1287-0107 19.4 µM 0.54145828626437 0.277693305768879 no 907 0.294095870974831 1512 51516812 YPR165W RHO1
SGTC_1814 st052110 31.539 µM 0.541032786024111 0.277852646058802 no 908 0.294242492353525 1461 674163
SGTC_1591 genipin 88.4 µM 0.539404346959276 0.278462871899991 no 909 0.294803941130567 1458 442424 A DNA cross-linking agent.
SGTC_382 3229-0966 23.2 µM 0.538276214242412 0.278886000195782 no 910 0.295193185010197 1506 5722370
SGTC_1489 4065-0444 182 µM 0.537605234806943 0.279137812466354 no 911 0.295424807727827 1473 2877968
SGTC_1749 st037932 54.2 µM 0.536477130724315 0.279561428303425 no 912 0.295814418613768 1426 594497
SGTC_1458 k015-0034 6.33 µM 0.53645636095185 0.279569230512954 no 913 0.295821594037847 1368 3598957
SGTC_2586 curcumin 80 µM 0.536344602405302 0.279611214665121 no 914 0.295860205123865 1501 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1993 st073995 70.8 µM 0.536311874834329 0.279623509958027 no 915 0.295871512500912 1462 3098394
SGTC_3215 9129942 49.47 µM 0.535971876217787 0.279751258228649 no 916 0.295988993775611 1413 17682944
SGTC_2820 7989630 71.43 µM 0.535656644729919 0.279869725995622 no 917 0.296097936279308 1369 2984098
SGTC_666 0272-0154 136 µM 0.53377661525073 0.28057676842479 no 918 0.296748047307274 1434 6870312
SGTC_609 0986-0026 86.3 µM 0.533485131387311 0.280686467166324 no 919 0.296848900422839 1481 2848610
SGTC_769 0302-0231 76 µM 0.532519940912718 0.281049860608917 no 920 0.297182967249269 1442 571869 YER009W NTF2
SGTC_2234 tolnaftate 200 µM 0.532011120744328 0.281241522451478 no 921 0.29735914665239 1429 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3207 9114163 49.47 µM 0.528550896814279 0.282546587104589 no 922 0.298558515479133 1604 849233
SGTC_1753 st043925 64 µM 0.524554964904393 0.284057313419359 no 923 0.299946300287023 1479 670181
SGTC_1118 chelidonine 707.474 nM 0.524254392684075 0.284171105656363 no 924 0.30005080679946 1530 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_439 amiodarone 34.4 µM 0.522565839726626 0.284810771918321 no 925 0.300638208849398 1511 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_302 1094-0063 18.9 µM 0.522322927702919 0.284902849591382 no 926 0.300722754085821 1398 5440289
SGTC_313 3474-0040 5.03 µM 0.521775751426674 0.285110312975278 no 927 0.300913237421083 1403 1043375 YIL048W NEO1
SGTC_283 0987-0079 11.7 µM 0.52118547098898 0.285334200134764 no 928 0.301118787189027 1484 411556
SGTC_448 monastrol 171 µM 0.519914045066155 0.285816722857266 no 929 0.301561742867254 1473 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1169 aniline yellow 25.8 µM 0.519345498075182 0.286032619344065 no 930 0.301759915369489 1485 6051 A DNA damaging agent.
SGTC_2796 7949634 45.45 µM 0.519345403062506 0.286032655430061 no 931 0.30175994849196 1421 2971588
SGTC_2197 6588183 93.1375 µM 0.51916142163353 0.286102535987144 no 932 0.301824089520865 1428 884136
SGTC_41 0478-0632 82.643 µM 0.518901133254219 0.286201413605839 no 933 0.301914843734092 1476 3750424
SGTC_2520 obtusaquinone 4.71 µM 0.518147053779113 0.286487962781615 no 934 0.302177836256219 1549 5967872
SGTC_864 0469-0573 172 µM 0.516737968683984 0.287023777747468 no 935 0.302669543710274 1416 689425
SGTC_420 mitomycin C 81.9 mM 0.516513558092979 0.287109155318615 no 936 0.302747886014824 1422 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1726 st035556 14.5795 µM 0.514202931175426 0.28798893765656 no 937 0.303555059324229 1547 5919439
SGTC_2247 cerulenin 830 nM 0.513906752681215 0.288101801002213 no 938 0.30365859306604 1517 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1129 3453-1384 223 µM 0.513646480402184 0.288200998962133 no 939 0.30374958824885 1530 1084452
SGTC_155 k072-0202 43.6 µM 0.513490433341443 0.288260481134801 no 940 0.303804150529819 1418 5857737
SGTC_506 n9-isopropylolomoucine 153 µM 0.512963874441411 0.288461238096744 no 941 0.30398829554971 1580 6610355
SGTC_68 0986-0284 82.829 µM 0.512750221534758 0.288542714645755 no 942 0.304063027151815 1397 423278 YIL048W NEO1
SGTC_2954 9074818 52.69 µM 0.512716499275878 0.288555575621981 no 943 0.30407482328566 1508 16648742
SGTC_1870 st057514 26.5 µM 0.511889447743801 0.288871080579814 no 944 0.304364191878317 1465 5393161
SGTC_2228 7354201 200 µM 0.511087200849003 0.289177278065953 no 945 0.304644998907183 1534 753451
SGTC_1084 voriconazole 435 nM 0.510728329538453 0.28931429961033 no 946 0.304770650375332 1481 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2903 5923464 63.88 µM 0.510189846156888 0.289519956502933 no 947 0.304959232550268 1480 2876576
SGTC_1616 st002734 56.1 µM 0.509990726222301 0.289596021519341 no 948 0.305028979434213 1479 4026101
SGTC_759 3486-0358 89.3 µM 0.509803109360315 0.289667700876387 no 949 0.305094703551986 1599 875103
SGTC_1216 1165-0504 9.65 µM 0.508970108473549 0.289986050872353 no 950 0.305386588232181 1512 6304004
SGTC_226 1,3-diallylurea 8.28947 mM 0.508380589060006 0.290211448032891 no 951 0.305593231466888 1456 74537 YKL182W FAS1
SGTC_798 1287-0182 476 µM 0.507200604763795 0.290662850232351 no 952 0.306007035365874 1570 1649755
SGTC_2428 5615643 7.78 µM 0.505518257717181 0.291306998277251 no 953 0.306597439096032 1500 2253075
SGTC_227 fluconazole 33.516 µM 0.505082423389766 0.291473981968041 no 954 0.306750472990903 1428 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_593 1203-0218 61.7 µM 0.504301587492325 0.291773259673721 no 955 0.307024731039649 1556 3666956
SGTC_2449 5812982 45.77 µM 0.503808584700494 0.291962290814143 no 956 0.307197947240699 1469 776185
SGTC_1938 st074717 56.4 µM 0.503273594177761 0.292167485727168 no 957 0.307385964483517 1402 17250979
SGTC_634 1611-4317 11.2 µM 0.503252765244378 0.292175475994223 no 958 0.307393285634845 1519 2843522
SGTC_1903 st060211 78.3 µM 0.503148552985386 0.292215454785656 no 959 0.307429916301849 1562 688960
SGTC_1507 4075-3230 155 µM 0.502860442430842 0.292325995444359 no 960 0.307531197316668 1419 659771
SGTC_3039 9090270 49.47 µM 0.501693486297596 0.292773925474724 no 961 0.307941573554495 1513 17173750
SGTC_200 k038-0079 37.545 µM 0.500599393189815 0.293194176655661 no 962 0.308326544798049 1504 3436683
SGTC_993 3909-8757 62.7 µM 0.499981749126121 0.293431542841086 no 963 0.30854396425518 1487 4288324 YLR208W SEC13
SGTC_2990 9074105 71.4286 µM 0.499917747430921 0.293456144359428 no 964 0.308566497599045 1492 6502001
SGTC_386 1509-0011 3.07 µM 0.499492065236622 0.293619796022714 no 965 0.308716387646675 1476 3107280
SGTC_2340 7987427 183.45 µM 0.498815228710078 0.293880089833735 no 966 0.308954779091116 1519 2239331
SGTC_649 1123-0311 367 µM 0.498534211126057 0.293988193270248 no 967 0.309053781132518 1466 693629 YIL048W NEO1
SGTC_1934 st074720 32.6 µM 0.498355770957589 0.29405684618772 no 968 0.309116652516505 1443 17250992
SGTC_2653 dihydrofissinolide 100 µM 0.498324198049463 0.294068994292903 no 969 0.309127777457362 1500 6857746
SGTC_1788 fluconazole 20 µM 0.497942080866924 0.294216037457472 no 970 0.309262433066027 1458 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_983 1491-0821 12.2 µM 0.496185342402916 0.29489248761806 no 971 0.309881825731823 1547 46495113
SGTC_27 0485-0001 32.618 µM 0.496054267515283 0.29494298807065 no 972 0.309928061923313 1463 2054479
SGTC_351 caspofungin 25 nM 0.494978797626871 0.295357494856884 no 973 0.310307543505537 1581 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2876 9059903 25.97 µM 0.491726714750582 0.296612537853729 no 974 0.31145627506107 1472 6916095
SGTC_1560 lithocholic acid 53.1 µM 0.490425391824795 0.297115427471924 no 975 0.311916456217105 1494 9903 A bile acid which acts as a detergent.
SGTC_962 1254-0300 21.5 µM 0.490205814127481 0.297200320579925 no 976 0.311994133505344 1513 7340576
SGTC_3000 9075062 71.4286 µM 0.489984071031447 0.297286062124118 no 977 0.312072585305508 1475 17057871
SGTC_2982 9019404 25.97 µM 0.489901103765912 0.297318146035066 no 978 0.312101940976173 1324 22333232
SGTC_2023 5144124 124 µM 0.488943023492503 0.297688755655907 no 979 0.312441017571471 1474 2830192
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.488502681433439 0.297859161747982 no 980 0.312596913440671 1570 688798
SGTC_2904 7225135 42.03 µM 0.488112244991274 0.29801029227303 no 981 0.312735169099101 1544 4446116
SGTC_86 0417-1630 471.922 µM 0.487404467007502 0.298284348737944 no 982 0.312985864285976 1523 3634867
SGTC_1608 st001473 40.5 µM 0.487244295410219 0.298346384192111 no 983 0.313042609122353 1444 7292267
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.486799168435394 0.298518815464793 no 984 0.313200329855115 1526 756377
SGTC_1527 coumarin 137 µM 0.4866494470511 0.29857682404436 no 985 0.313253387943418 1550 323 A hepatotoxic, DNA x-linker.
SGTC_2829 7992743 58.44 µM 0.486609616980479 0.298592256810289 no 986 0.313267503528138 1590 16462845
SGTC_1687 st020778 55.3625 µM 0.485560672031266 0.298998816978028 no 987 0.313639342978344 1518 4259299
SGTC_2526 patulin 37.61 µM 0.485092659267218 0.299180294932233 no 988 0.313805309491956 1550 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2193 5925765 200 µM 0.4832445422678 0.29989741394785 no 989 0.314461056005789 1549 877370
SGTC_2560 caryophyllene 100 µM 0.481338196696971 0.300637941315975 no 990 0.315138076972641 1518 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1428 4049-0204 61.7 µM 0.479329387851225 0.301419162862854 no 991 0.315852159309043 1598 X1428
SGTC_1472 k841-0093 193 µM 0.476820107079714 0.302396298312345 no 992 0.316745113229016 1573 X1472
SGTC_3346 9158254 43.5805 µM 0.476075115556657 0.302686677672125 no 993 0.317010432295347 1510 17639500
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.475812591519542 0.302789032838735 no 994 0.317103949257806 1490 4330530
SGTC_3094 9117742 49.47 µM 0.474189808482838 0.303422081411686 no 995 0.317682280154214 1456 17149698
SGTC_2121 5257820 149.641 µM 0.474101129519464 0.303456692159012 no 996 0.31771389659296 1586 791256
SGTC_2607 solasodine 47.35 µM 0.47278331336111 0.303971233808153 no 997 0.318183890091706 1513 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1508 1080-0625 72.9 µM 0.470649923205404 0.304805039999693 no 998 0.318945375226494 1502 767111
SGTC_2970 9090938 41.86 µM 0.470235791089693 0.304967015590246 no 999 0.319093282901754 1670 17217104
SGTC_2844 9010103 25.97 µM 0.470165558024489 0.30499448897846 no 1000 0.319118369564592 1513 2480525
SGTC_1725 st036284 20.55 µM 0.469572122242144 0.305226669828035 no 1001 0.319330372919267 1690 707914
SGTC_2706 st078239 82.5 µM 0.46944012288042 0.305278325039732 no 1002 0.319377537375067 1504 15434492
SGTC_1309 pyrazolanthrone 13.4 µM 0.468782773865234 0.30553562266826 no 1003 0.31961245708132 1619 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2966 9084041 48.03 µM 0.468353037957821 0.305703880580709 no 1004 0.319766072833816 1388 17741380
SGTC_1617 st002906 78 µM 0.467910986487621 0.30587700331526 no 1005 0.319924123237643 1513 5150859
SGTC_2355 9061122 103.12 µM 0.467186930372329 0.306160662596133 no 1006 0.320183071771804 1622 5302957
SGTC_185 k048-0037 25.491 µM 0.46623494735139 0.30653379237937 no 1007 0.320523668474229 1585 6827589
SGTC_1411 3909-8223 150 µM 0.465473840593124 0.306832252564871 no 1008 0.32079608300723 1614 X1411
SGTC_1261 0712-0010 12.7 µM 0.464974722968966 0.307028045964787 no 1009 0.320974779077311 1622 2840123
SGTC_2014 4013930 200 µM 0.464490705077997 0.30721796862749 no 1010 0.321148108694303 1505 64556
SGTC_3084 9116877 49.47 µM 0.463952874971071 0.307429067207796 no 1011 0.321340754489764 1535 27241325
SGTC_2745 rifampicin 24.3 µM 0.461737221904278 0.308299384360844 no 1012 0.322134887537748 1642 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3310 9130229 44.1445 µM 0.459741549804123 0.309084215772164 no 1013 0.322850871029251 1595 7761258
SGTC_3266 9136860 49.47 µM 0.459381154379613 0.309226040376075 no 1014 0.322980239536135 1493 4871271 YPR165W RHO1
SGTC_906 1165-0455 526 µM 0.458666696463036 0.309507281452314 no 1015 0.323236766572623 1500 3252859
SGTC_3139 9095020 49.47 µM 0.458322956580448 0.309642631888424 no 1016 0.32336021678375 1416 25236292
SGTC_1785 bathophenanthroline 24 µM 0.457808479329563 0.309845259818279 no 1017 0.323545021687708 1483 72812 An iron chelator.
SGTC_362 0310-0100 9.03 µM 0.456780174600905 0.310250432892109 no 1018 0.323914528513016 1543 790235
SGTC_2239 6685329 187.64 µM 0.45602257207373 0.310549091228318 no 1019 0.324186873396934 1526 805680
SGTC_2563 tomatine 8.54 µM 0.455205352078609 0.310871391726008 no 1020 0.324480755222892 1772 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2723 salbutamol 83.58 µM 0.454050021976723 0.311327285894139 no 1021 0.324896411906769 1573 9884233 β2-adrenoceptor agonist
SGTC_2273 7815444 169.05 µM 0.453724337280128 0.311455853673164 no 1022 0.32501362392334 1669 2824616
SGTC_623 k072-0108 16.9 µM 0.452329092320074 0.312006902791279 no 1023 0.325515960354901 1559 5382803
SGTC_161 4065-0411 162.148 µM 0.449667113742494 0.313059412834051 no 1024 0.326475243746429 1607 1906281 YLR208W SEC13
SGTC_2360 9040895 200 µM 0.449352535480212 0.313183893719792 no 1025 0.32658868269727 1521 4914414
SGTC_367 0335-0881 7.1 µM 0.448670243316272 0.313453954803971 no 1026 0.326834776751317 1618 23828853
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.4483281012317 0.313589417248553 no 1027 0.32695821139461 1600 77254
SGTC_1139 k015-0024 46.9 µM 0.447807745212653 0.31379548715362 no 1028 0.327145976596319 1597 2766652
SGTC_1273 0849-0096 14.1 µM 0.447598768595482 0.313878261832528 no 1029 0.3272213960108 1536 5286025
SGTC_3038 9091290 49.47 µM 0.447227870060193 0.314025196104951 no 1030 0.327355270224917 1598 25236843
SGTC_184 1494-0393 24.714 µM 0.446355567858257 0.314370881447379 no 1031 0.327670211422505 1513 3090647
SGTC_1643 st009866 20.2 µM 0.44570047569679 0.314630595540516 no 1032 0.327906810460276 1612 3156273 YOR207C RET1
SGTC_738 1315-0003 72.4 µM 0.445530999485462 0.314697800052277 no 1033 0.327968031281263 1637 6251474
SGTC_2513 baicalein 25.65 µM 0.443426013821239 0.315533027249882 no 1034 0.328728811631365 1483 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3018 9082602 49.47 µM 0.439544510593142 0.317075621494869 no 1035 0.330133518787901 1572 17332089
SGTC_863 0466-0191 129 µM 0.438538335570228 0.317476018255654 no 1036 0.330498043396226 1645 765160 YPR165W RHO1
SGTC_1064 honokiol 6.76 µM 0.438387241403893 0.317536163050198 no 1037 0.330552796820915 1567 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_847 0342-0274 5.54 µM 0.438375141066842 0.317540979938781 no 1038 0.330557181891576 1681 18097
SGTC_339 3091-4833 71.4 µM 0.437560780036962 0.317865230829286 no 1039 0.330852353606226 1609 3240077
SGTC_674 0498-0004 451 µM 0.435501063674025 0.318685962992143 no 1040 0.331599383546676 1534 4231473
SGTC_29 0299-0004 12.984 µM 0.433736143171796 0.319389936764397 no 1041 0.332240028637695 1528 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1368 1852-0141 284 µM 0.433605072809448 0.319442242814213 no 1042 0.332287625206002 1576 2838987
SGTC_3073 9114972 49.47 µM 0.432141888524059 0.320026397269746 no 1043 0.33281914584376 1686 41905075
SGTC_2048 5246248 200 µM 0.432086620214924 0.320048471075756 no 1044 0.332839229367708 1646 677046
SGTC_146 3448-8650 53.125 µM 0.431248384998942 0.320383334873254 no 1045 0.333143887958442 1604 2891488 YIL048W NEO1
SGTC_1880 MG-132 525 µM 0.430773163668735 0.32057324446174 no 1046 0.333316657222269 1656 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1109 tnp00067 928.257 nM 0.430469581926786 0.320694587441725 no 1047 0.333427044510626 1564 676295
SGTC_1797 st048695 56.8 µM 0.430318158104352 0.320755119384258 no 1048 0.33348211008303 1662 592262 YIL048W NEO1
SGTC_3247 9135149 49.47 µM 0.430091808589095 0.320845611892524 no 1049 0.333564429222131 1578 8934436 YOR116C RPO31
SGTC_1398 3558-0053 112 µM 0.430055835451546 0.320859994611082 no 1050 0.333577512726147 1554 4532369
SGTC_1070 indatraline 8.81 µM 0.42881550364162 0.3213560662849 no 1051 0.334028747663305 1554 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_3296 9122258 64.045 µM 0.428365000304198 0.32153632442882 no 1052 0.334192701047242 1592 4730474
SGTC_3286 9117135 37.221 µM 0.427170665796055 0.322014412165541 no 1053 0.334627512793862 1521 3438150
SGTC_2777 climbazole 1.536 µM 0.425144103327316 0.322826311731871 no 1054 0.335365814487522 1626 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1808 st050063 61.5 µM 0.424832781012691 0.322951111448071 no 1055 0.335479289497064 1651 4011993
SGTC_1892 st058411 7.36 µM 0.424309715057087 0.323160837680901 no 1056 0.335669977509804 1669 3934738
SGTC_2005 4024620 188 µM 0.423092896579623 0.323648945326261 no 1057 0.33611374242149 1571 236743
SGTC_971 1315-0384 26.7 µM 0.422151756556487 0.324026677115926 no 1058 0.336457126145937 1550 6769120
SGTC_1815 st051655 58.2 µM 0.421301003255556 0.324368287691063 no 1059 0.336767648864275 1675 5984156
SGTC_1803 st050068 52.4 µM 0.418768343701643 0.325386123541408 no 1060 0.337692721185803 1621 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_586 0957-0265 8.15 µM 0.418533178604554 0.32548069894215 no 1061 0.337778666829232 1604 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1658 st012944 20 µM 0.41794445237014 0.325717513874824 no 1062 0.337993865333929 1648 24207260
SGTC_2850 9015429 58.44 µM 0.415768823948983 0.326593269422285 no 1063 0.338789586958269 1556 6457570
SGTC_2135 5326629 150.42 µM 0.415513194499228 0.32669623081004 no 1064 0.338883129064998 1568 5020077
SGTC_218 alverine citrate 93.75 µM 0.415221737046368 0.326813638959457 no 1065 0.338989793782536 1654 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_534 k292-0788 63.4 µM 0.415167179962059 0.326835618159924 no 1066 0.339009761479571 1761 4146317
SGTC_2686 alizarin 95.37 µM 0.414654805739759 0.327042065681075 no 1067 0.339197310668645 1540 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_297 0986-0032 24 µM 0.414618967926662 0.327056507553196 no 1068 0.339210430214399 1591 2847425
SGTC_1501 4491-0275 38.4 µM 0.414527463705882 0.327093382971702 no 1069 0.339243929063761 1694 5104718
SGTC_1012 4112-3522 18 µM 0.414343220760591 0.327167636424138 no 1070 0.339311382557632 1715 3112398
SGTC_771 0250-0039 27.3 µM 0.412729820813661 0.327818159628538 no 1071 0.339902286901429 1615 3005115
SGTC_2801 7907800 81.82 µM 0.412632534263025 0.327857402319832 no 1072 0.339937930492006 1596 6620925
SGTC_1646 st011709 75.6 µM 0.412495654419693 0.327912619063976 no 1073 0.33998808259187 1678 5757843
SGTC_2413 inermin 26.06 µM 0.412427928478389 0.327939940810671 no 1074 0.340012898090152 1755 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1975 st070967 30.8 µM 0.4085813482534 0.329493221443631 no 1075 0.341423460398924 1728 261391
SGTC_1590 st077108 57.8 µM 0.408148530323653 0.329668181784662 no 1076 0.34158231632283 1715 5489485
SGTC_2315 7733312 200 µM 0.40738588582825 0.329976560417707 no 1077 0.341862295824256 1573 726316
SGTC_1200 1643-0193 18.4 µM 0.406238690961998 0.330440651310273 no 1078 0.342283613994418 1643 5403974
SGTC_2623 humulene 100 µM 0.405463502840224 0.330754396833683 no 1079 0.342568420387562 1574 6187145 An anti-inflammatory.
SGTC_1436 4092-1007 8.32 µM 0.404882356111316 0.330989685094813 no 1080 0.342781994130682 1610 2881121
SGTC_2792 7535235 81.82 µM 0.404505490461368 0.331142301985758 no 1081 0.342920520629402 1543 1281891
SGTC_2701 st077767 14.721 µM 0.403774337175871 0.331438472492118 no 1082 0.34318933472435 1615 5721188
SGTC_1214 0358-0031 63.7 µM 0.402163633669127 0.332091296892706 no 1083 0.343781802033996 1806 4301366
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.401302974508971 0.33244033457976 no 1084 0.344098536944026 1599 688803
SGTC_2788 5282734 71.43 µM 0.401150960116505 0.332501998662826 no 1085 0.344154491794834 1747 743706
SGTC_2073 5212005 126 µM 0.398728294555312 0.333485354945136 no 1086 0.345046708541986 1670 691789
SGTC_2693 st077581 40.7 µM 0.397677838146673 0.33391208998601 no 1087 0.345433837789697 1648 25238761
SGTC_742 0kpi-0133 140 µM 0.396477743607835 0.33439987663847 no 1088 0.345876311762981 1751 2728852
SGTC_193 1273-0060 1.558 µM 0.395701986038327 0.334715337531453 no 1089 0.346162445100161 1624 2847393 YHR072W ERG7
SGTC_2719 novobiocin 32.65 µM 0.392668405654982 0.335950058049543 no 1090 0.347282204370736 1735 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2634 4'-methoxyflavone 100 µM 0.39159538962085 0.336387219500238 no 1091 0.347678597472232 1620 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2893 9048488 25.97 µM 0.391308795429791 0.336504019374456 no 1092 0.347784499175927 1572 6467338
SGTC_191 3914-0123 66.505 µM 0.390764367029819 0.33672594159779 no 1093 0.347985707958714 1593 3144412
SGTC_2976 9009005 19.48 µM 0.390479663522094 0.336842016304017 no 1094 0.348090945174451 1787 2993148
SGTC_3121 9125696 49.47 µM 0.387815032683359 0.337929148610175 no 1095 0.349076460020969 1701 1235365
SGTC_1127 asiatic acid 681.4 nM 0.38674545721843 0.338365901649537 no 1096 0.349472329880301 1601 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2133 5320837 200 µM 0.386729568626683 0.338372391276856 no 1097 0.349478211780462 1698 2841355
SGTC_2744 captopril 92.04 µM 0.386070459998292 0.338641643659469 no 1098 0.349722243282827 1758 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_45 0kpi-0036 14.9 µM 0.385714537009137 0.338787076024414 no 1099 0.349854047726524 1667 2795021
SGTC_228 caffeine 993.056 µM 0.384717232003125 0.339194709079685 no 1100 0.35022346337902 1717 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1960 st011366 51.8 µM 0.384521165369623 0.339274870457437 no 1101 0.350296105873189 1633 3972846
SGTC_346 4513-0042 7.16 µM 0.384415583444002 0.339318040390868 no 1102 0.350335226141299 1614 2827372
SGTC_2523 spermine 47.74 µM 0.383070670609414 0.339868127571135 no 1103 0.350833682724983 1776 1103 A DNA binding polyamine.
SGTC_15 0266-0086 27.098 µM 0.381833842591489 0.340374307812447 no 1104 0.351292307264777 1722 1712902 YIL048W NEO1
SGTC_279 1273-0055 2.93 µM 0.379985825136523 0.341131157397365 no 1105 0.351977968645575 1763 2847562
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.37933818598149 0.341396547440775 no 1106 0.352218373288147 1658 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1973 st070275 50.2 µM 0.378909863465109 0.341572108860014 no 1107 0.352377399716099 1680 17118334
SGTC_2059 5238311 157 µM 0.37873993869003 0.341641767359096 no 1108 0.352440496080569 1621 703021
SGTC_3134 9127454 49.47 µM 0.378716592221398 0.341651338368264 no 1109 0.352449165394477 1693 24262820
SGTC_3313 9133968 57.047 µM 0.378258224796751 0.341839269149104 no 1110 0.35261938785958 1663 1494643
SGTC_189 3970-0742 2.116 µM 0.377421900633679 0.342182263290502 no 1111 0.352930046962257 1770 2891807
SGTC_1782 st039423 80.636 µM 0.376916137219764 0.342389750730356 no 1112 0.353117964309108 1600 2068169
SGTC_111 0083-0039 52.457 µM 0.376846534626753 0.342418308644609 no 1113 0.353143828088697 1659 759313
SGTC_2350 9023895 38.85 µM 0.376040203991769 0.342749211401509 no 1114 0.353443503675999 1739 2997209
SGTC_1851 st056236 18.9 µM 0.373084590723834 0.343963169191047 no 1115 0.354542743447576 1792 5393171
SGTC_2848 9016370 25.97 µM 0.372997561695327 0.343998939051604 no 1116 0.354575129354875 1808 7894410
SGTC_3011 9081274 71.4286 µM 0.372859406258966 0.344055725279215 no 1117 0.354626542970909 1650 6625322
SGTC_1750 st081859 2.357 µM 0.372514811281682 0.344197379972641 no 1118 0.354754793212847 1705 5291695
SGTC_1751 st044839 27.194 µM 0.371141051212236 0.344762316787378 no 1119 0.355266238303201 1702 5291326
SGTC_2895 9054447 58.44 µM 0.370841528150568 0.344885536876993 no 1120 0.355377784141274 1675 2697450
SGTC_2566 crystal violet carbinol 226 nM 0.370808179129325 0.344899257270778 no 1121 0.355390204467653 1568 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2226 7298446 200 µM 0.370222028260226 0.345140443678709 no 1122 0.355608532342434 1758 3283010
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.369933227718203 0.345259301014567 no 1123 0.355716121408089 1821 1273210
SGTC_895 0964-0006 13.7 µM 0.369711043060335 0.345350752632929 no 1124 0.355798901375068 1743 6738897
SGTC_1550 gossypolone 36.6 µM 0.369497070202056 0.345438832794635 no 1125 0.355878628276486 1676 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2288 7946289 167.31 µM 0.369174365729966 0.345571687257908 no 1126 0.355998880810793 1794 1246052
SGTC_1807 st050092 58.9 µM 0.368106320827847 0.34601152711738 no 1127 0.356396978982002 1660 5008496
SGTC_1963 st076565 50.3 µM 0.367003322087169 0.346465979758433 no 1128 0.356808269995958 1650 4914280
SGTC_592 k241-0073 46.5 µM 0.364380478191965 0.347547519186502 no 1129 0.357786955549868 1757 4230158
SGTC_2125 5246583 200 µM 0.363115366747794 0.348069637236676 no 1130 0.358259352972695 1850 835267
SGTC_2818 7996756 12.99 µM 0.362997864767959 0.348118145551714 no 1131 0.358303239685131 1653 2241621
SGTC_2300 7976697 71.57 µM 0.362965248762055 0.348131610850542 no 1132 0.358315422018382 1614 2236109
SGTC_1378 2093-0007 380 nM 0.362514798216575 0.348317595906203 no 1133 0.358483683564543 1679 3618014
SGTC_2175 5807670 165.306 µM 0.362428745929582 0.348353129905512 no 1134 0.358515830710484 1760 241186
SGTC_1179 1021-1431 9.29 µM 0.361796852548351 0.348614101540531 no 1135 0.358751922175126 1704 2840958
SGTC_2099 5377090 177.372 µM 0.36161098094522 0.348690880059987 no 1136 0.358821378819326 1665 2243829
SGTC_2116 5511452 16.8835 µM 0.35980784995889 0.349436025845449 no 1137 0.359495416204788 1710 870744
SGTC_3243 9134147 49.47 µM 0.359251092882595 0.349666223746697 no 1138 0.359703628821054 1741 24282180
SGTC_1191 1487-1166 10.6 µM 0.359212130794289 0.349682335160909 no 1139 0.359718201185223 1759 3955771
SGTC_570 0987-0065 62.6 µM 0.358168820767941 0.350113860277875 no 1140 0.360108489468607 1777 3104428
SGTC_3026 9090633 49.47 µM 0.355888991381971 0.351057497282148 no 1141 0.36096185019231 1657 25236842
SGTC_1968 st069590 43.6 µM 0.355652392365454 0.351155479981242 no 1142 0.361050451079144 1769 6384066
SGTC_2679 rapamycin 1 nM 0.355255170624737 0.351320003584201 no 1143 0.361199218243927 1720 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_3226 9131256 49.47 µM 0.354274330002785 0.351726373131599 no 1144 0.361566651762045 1680 17178073
SGTC_121 0557-0495 61.343 µM 0.353045482390355 0.352235732944569 no 1145 0.362027171564046 1713 3104427
SGTC_424 splitomicin 100 mM 0.352547843895138 0.352442080595233 no 1146 0.36221372218256 1623 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2641 levomentholum 100 µM 0.352525802516299 0.352451221139822 no 1147 0.362221985630313 1733 16666
SGTC_352 k048-0007 5.11 µM 0.352147648686565 0.352608054539569 no 1148 0.362363767811878 1700 6811911
SGTC_907 3448-6986 75.5 µM 0.349529543776476 0.353694558675509 no 1149 0.363345897509219 1796 590582
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.34709584020235 0.354705607101699 no 1150 0.36425965925448 1732 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2684 capsaicin 100 µM 0.346071559885527 0.355131436876507 no 1151 0.364644468141156 1733 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_208 k072-0098 12.366 µM 0.345994052685734 0.355163666749757 no 1152 0.364673592151965 1719 5948901
SGTC_1919 st067113 52.3 µM 0.345051024112155 0.355555889920562 no 1153 0.365028005933452 1677 1268243
SGTC_1912 st060209 90.8 µM 0.345000797539326 0.355576784384175 no 1154 0.365046885576478 1641 688787
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.344883593316287 0.35562554351734 no 1155 0.365090942689544 1677 2374 Ca(2+)-ATPase inhibitor.
SGTC_84 0443-0269 128.823 µM 0.342405405163873 0.356657067778097 no 1156 0.366022910670261 1755 6150058
SGTC_3145 9085516 49.47 µM 0.342029510129049 0.356813622646951 no 1157 0.366164342100708 1660 25236195
SGTC_2696 st077691 74.316 µM 0.340734540106794 0.357353143546528 no 1158 0.366651716876152 1724 757133
SGTC_2468 5987765 72.9 µM 0.339840583370754 0.357725757553297 no 1159 0.366988291875634 1759 26772094
SGTC_2180 6301957 200 µM 0.339368476144734 0.357922593375713 no 1160 0.367166081679228 1820 845462
SGTC_2937 9044753 11.33 µM 0.339292272813167 0.357954368398607 no 1161 0.367194781592422 1675 6465530 YGL099W LSG1
SGTC_2380 9035439 200 µM 0.338229868361424 0.358397468843313 no 1162 0.367594984570131 1794 6462575
SGTC_2915 7971052 15.16 µM 0.337375235912545 0.358754051614019 no 1163 0.367917025178286 1766 5741558
SGTC_1423 4048-0112 5.59 µM 0.336695719846433 0.359037657559422 no 1164 0.368173145123412 1810 X1423
SGTC_615 k087-0205 167 µM 0.336329544442211 0.35919051843853 no 1165 0.368311186511125 1643 9642773
SGTC_2249 haloperidol 116.36 µM 0.333756280667506 0.360265368750638 no 1166 0.369281738207211 1772 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1957 st077035 62.4 µM 0.333579853038324 0.360339103024627 no 1167 0.369348311603029 1755 705593
SGTC_2334 9017922 200 µM 0.333546313831238 0.360353120629369 no 1168 0.36936096776763 1850 3163164
SGTC_1949 st076024 69.1 µM 0.33246778573869 0.360803987987999 no 1169 0.369768030411355 1641 2921930
SGTC_712 r015-0009 80.6 µM 0.331568562473759 0.361180046818841 no 1170 0.370107530685527 1794 6813872 YLR060W FRS1
SGTC_2472 5377652 49.4 µM 0.331442142792622 0.361232926812015 no 1171 0.370155268352085 1710 1610903
SGTC_57 miconazole 162.5 nM 0.331253993239769 0.361311632656385 no 1172 0.370226319700651 1666 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1920 st075728 45.7 µM 0.329653528519101 0.361981368647637 no 1173 0.370830885699997 1889 3400306
SGTC_2170 morpholine 200 µM 0.329619963974413 0.361995418716869 no 1174 0.370843567927025 1799 121171 Reacts with secondary amines.
SGTC_2207 7258803 200 µM 0.32941436633706 0.362081485644689 no 1175 0.370921255221692 1798 3666799
SGTC_3028 9087778 49.47 µM 0.329175483015573 0.362181495327073 no 1176 0.371011526480946 1667 17217395
SGTC_2427 5545055 42.75 µM 0.32896985764459 0.362267588939679 no 1177 0.371089235628512 1767 5372858
SGTC_1347 1493-0251 600 nM 0.328078113798763 0.362641035160979 no 1178 0.371426300819133 1845 3986378
SGTC_4 0960-0234 25.671 µM 0.327358308896659 0.36294257181196 no 1179 0.371698447731776 1729 6821112
SGTC_2730 imipramine 71.33 µM 0.326946805202788 0.363114994838401 no 1180 0.371854059627482 1825 3696 A tricyclic antidepressant.
SGTC_3227 9130768 49.47 µM 0.325482681003296 0.363728698247536 no 1181 0.372407894115663 1791 17720899
SGTC_2541 muurolladie-3-one 83.07 µM 0.324815891494347 0.364008306264766 no 1182 0.372660208240501 1775 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_215 1287-0124 461.5 µM 0.324521979208422 0.364131576905857 no 1183 0.372771442439603 1862 5560863
SGTC_1124 fisetin 1.16336 µM 0.324194653210993 0.364268878239301 no 1184 0.372895334897277 1709 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3032 9089427 49.47 µM 0.322845550466148 0.36483496139338 no 1185 0.373406107143002 1727 17173707
SGTC_1932 st074806 40.9 µM 0.321127575674026 0.365556249746049 no 1186 0.374056856862481 1804 17251235
SGTC_467 ro 31-8220 72.8 µM 0.320788883162107 0.365698505345764 no 1187 0.37418519224604 1861 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1794 st048918 76.9 µM 0.319632422202448 0.366184374253918 no 1188 0.37462349667381 1869 672303
SGTC_2091 4-phenylthiadiazole 200 µM 0.319106701985703 0.366405318354106 no 1189 0.374822800846107 1740 270010
SGTC_1229 0139-0193 12.2 µM 0.318738580315809 0.366560054981573 no 1190 0.374962378226334 1862 3090752
SGTC_817 1391-0715 46 µM 0.318474201140932 0.366671197771234 no 1191 0.375062630604599 1705 1353946
SGTC_1710 st031758 61.5 µM 0.314017699541868 0.368546349481296 no 1192 0.376753797962651 1849 5394341
SGTC_1152 3909-8331 15.9 µM 0.313325346478726 0.368837951706474 no 1193 0.377016747612649 1745 16001939
SGTC_794 k038-0031 316 µM 0.311698318147828 0.369523513377318 no 1194 0.377634903125447 1735 6624242
SGTC_183 3914-0051 30.55 µM 0.311573009154958 0.369576330585596 no 1195 0.377682524690349 1904 1596232
SGTC_2244 6635614 200 µM 0.310837215766811 0.369886513998756 no 1196 0.377962188021816 1763 836499
SGTC_1583 clindamycin 39.6 µM 0.309509996044651 0.370446234975885 no 1197 0.378466804739539 1689 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2258 7960471 200 µM 0.308674923027689 0.370798546375469 no 1198 0.378784410711543 1744 2974708
SGTC_1092 toremifene 6.32 µM 0.307311713981662 0.371373907328722 no 1199 0.379303060174554 1796 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1184 1269-1718 139 µM 0.306483353245582 0.371723668803493 no 1200 0.379618326299715 1875 5403821
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.305737862543829 0.372038530351053 no 1201 0.379902121330585 1753 6857784
SGTC_53 0973-0023 39.979 µM 0.305703303326618 0.372053128678324 no 1202 0.379915278979064 1946 674768
SGTC_2608 thymoquinone 42.66 µM 0.305261479736919 0.372239777731656 no 1203 0.380083505666143 1798 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2386 9075165 157.42 µM 0.305115993226579 0.372301245303088 no 1204 0.38013890539799 1790 16452277
SGTC_440 fluspirilene 35.1 µM 0.30489881986951 0.372393006383887 no 1205 0.380221607301689 1843 3396 An atypical antipsychotic.
SGTC_3295 9122362 53.5725 µM 0.304728292035503 0.372465063662896 no 1206 0.380286549936993 1724 4730473
SGTC_975 1335-0046 28.5 µM 0.304544438847859 0.372542756629586 no 1207 0.380356571088013 1676 16486740
SGTC_2268 7933382 153.85 µM 0.30438261786874 0.372611143482928 no 1208 0.380418204436943 1834 935025 YOR257W CDC31
SGTC_182 3448-4371 550.524 µM 0.304264413236248 0.372661100254103 no 1209 0.380463227387016 1967 3491403
SGTC_760 0568-0725 82.9 µM 0.304022795087156 0.372763221888372 no 1210 0.380555262335732 1903 3916171
SGTC_340 k038-0059 454 µM 0.303227258267612 0.373099524364994 no 1211 0.380858338607528 1800 23733424
SGTC_3274 9138298 49.47 µM 0.302045150940845 0.373599422878154 no 1212 0.381308821937318 1783 17015756
SGTC_2240 6690706 185.951 µM 0.301253995045961 0.373934111785574 no 1213 0.381610409453954 1684 805876
SGTC_1513 0337-0559 19 µM 0.300641894022242 0.374193118944428 no 1214 0.381843790838809 1703 775073
SGTC_3164 9100705 49.47 µM 0.299495735229749 0.374678262360504 no 1215 0.382280912789832 1871 17174235
SGTC_810 3825-7150 143 µM 0.299220730958001 0.374794695071373 no 1216 0.382385816241502 1946 22330411 YGL099W LSG1
SGTC_2021 4019055 173 µM 0.29892278194962 0.374920855123839 no 1217 0.382499481962023 1816 44827708 YER133W GLC7
SGTC_2068 5226020 147 µM 0.298055416814153 0.375288198256034 no 1218 0.382830434045939 1746 1810509
SGTC_3229 9132204 49.47 µM 0.297242646776435 0.37563252216074 no 1219 0.38314063247354 1837 17682924
SGTC_2219 9098279 200 µM 0.296707163914751 0.375859429600217 no 1220 0.383345043600442 1884 902349
SGTC_2327 6189656 200 µM 0.296292662477203 0.376035101418293 no 1221 0.383503294509227 1883 5349088
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.295168675204624 0.376511592982795 no 1222 0.383932515025829 1769 115019
SGTC_1705 st027868 56.3335 µM 0.294509272741463 0.376791220910631 no 1223 0.384184389414618 1880 292948
SGTC_2484 5809818 12.04 µM 0.294446804225306 0.376817714827025 no 1224 0.384208253282178 1770 2870548
SGTC_1798 st045719 60.953 µM 0.294218018538816 0.376914751519461 no 1225 0.384295656437064 1880 3980186
SGTC_1153 4055-0057 267 µM 0.293410246469722 0.377257420460685 no 1226 0.38460429719218 1756 882706
SGTC_3059 1327-0034 3 µM 0.293379790013694 0.377270342435705 no 1227 0.384615935698845 1751 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1958 st076513 41.9 µM 0.292926100366727 0.377462848799209 no 1228 0.384789319129059 1767 732122 YGL099W LSG1
SGTC_1391 3442-0225 151 µM 0.292769571953613 0.377529272889041 no 1229 0.384849143856942 1804 5227075
SGTC_1271 0832-2808 169 µM 0.292662291512764 0.377574800298495 no 1230 0.384890147729148 1911 3663794
SGTC_2113 5491891 107.031 µM 0.290270614239628 0.378590215013503 no 1231 0.385804608974381 1716 789979
SGTC_409 arachidonic acid 100 µM 0.28938932911978 0.378964586836187 no 1232 0.386141729981191 1811 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2835 9006588 71.43 µM 0.289203781140786 0.379043422503167 no 1233 0.386212719249323 1756 2345538
SGTC_539 4859-0462 2.54 µM 0.288165117739 0.379484822872332 no 1234 0.386610174378399 1937 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_81 0411-0046 9.971 µM 0.287746580248327 0.379662733027296 no 1235 0.386770365665254 1802 12925265
SGTC_2627 acetyl isogambogic acid 100 µM 0.286607010020457 0.38014726576776 no 1236 0.387206623153555 1719 6857789 A caspase activator and apoptosis inducer.
SGTC_2960 9079389 5.97 µM 0.286013527452879 0.380399682597537 no 1237 0.387433880374914 1921 16457355
SGTC_1848 st056003 16.4 µM 0.28512022232981 0.380779714355592 no 1238 0.387776018805145 1988 146492
SGTC_2845 9003024 42.97 µM 0.28377538523394 0.381352054686017 no 1239 0.388291259565566 1884 2990173
SGTC_631 k072-0230 41.5 µM 0.282497560223226 0.38189611632043 no 1240 0.38878100854568 1863 5773147
SGTC_1044 1222-0021 1.78 µM 0.282212532613406 0.382017504857422 no 1241 0.38889027455151 1855 4306703
SGTC_714 4296-0578 26.1 µM 0.281938034603938 0.382134419976995 no 1242 0.3889955123188 1939 1589775
SGTC_1220 1838-0075 193 µM 0.281875546486394 0.382161036629414 no 1243 0.389019470315672 1848 5529645
SGTC_1116 jasmonic acid 1.58368 µM 0.281153784934896 0.382468509433667 no 1244 0.389296224866856 1869 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1003 4049-0218 100 µM 0.280882945526316 0.382583907049349 no 1245 0.389400090893168 1882 295161
SGTC_259 usnic acid 108.925 µM 0.280378345045419 0.382798931968721 no 1246 0.38959362459495 1893 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1745 st081495 74 µM 0.28003555743706 0.382945024335837 no 1247 0.389725112455517 1825 13842402 YBL026W LSM2
SGTC_383 2324-0395 7.37 µM 0.279726125170507 0.38307691531959 no 1248 0.389843816579113 1879 3146421
SGTC_1998 st075797 76.8 µM 0.278953656588449 0.383406227898815 no 1249 0.39014019509107 1925 24208315
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.278284918761162 0.383691386872091 no 1250 0.39039682607471 1763 688669
SGTC_966 1300-0360 30.2 µM 0.278233222232567 0.383713433605588 no 1251 0.390416666827529 1789 70588
SGTC_380 3970-0968 6 µM 0.276570848099182 0.384422577441027 no 1252 0.391054825832493 1805 2891601
SGTC_2896 9052656 71.43 µM 0.276472833579237 0.384464401066919 no 1253 0.391092461226311 1847 6469436
SGTC_3176 9106582 49.47 µM 0.27604579578923 0.384646637398215 no 1254 0.391256446128835 1932 17018027
SGTC_14 0354-0009 295 µM 0.275926787029366 0.384697428360148 no 1255 0.391302149604659 1861 1713507
SGTC_1498 4478-3555 97.6 µM 0.275406534389479 0.384919486770494 no 1256 0.391501962207596 1942 3437919
SGTC_1451 4152-0210 104 µM 0.274755957533135 0.385197224323536 no 1257 0.391751868506988 1937 659563
SGTC_2685 mycophenolic acid 18.85 µM 0.274735054560548 0.385206148982088 no 1258 0.391759898713925 1892 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3125 9127534 49.47 µM 0.274031840512573 0.385506426142296 no 1259 0.392030076344306 1919 1639235
SGTC_52 0329-0193 875 nM 0.274003429739626 0.38551855917852 no 1260 0.392040992971274 1911 3739292
SGTC_2464 5717415 7.67 µM 0.273942908113633 0.385544405771768 no 1261 0.392064248236637 1744 5285744
SGTC_1045 1348-1485 165 µM 0.273469396230482 0.385746643074286 no 1262 0.392246207154944 1860 6810614
SGTC_2271 7849410 118.62 µM 0.271375192738927 0.386641450820923 no 1263 0.393051239864398 1997 972430
SGTC_2662 daunorubicin 22.37 µM 0.270860578674219 0.386861426734052 no 1264 0.393249132815485 1832 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.270541810033922 0.38699770518478 no 1265 0.39337172796616 1802 6708760
SGTC_43 0570-0105 72.5 µM 0.26546553443191 0.389169757151603 no 1266 0.39532542858927 1835 1114046 YDL195W SEC31
SGTC_1178 0988-0033 191 µM 0.264469250960589 0.389596459131511 no 1267 0.395709177858877 1901 5392207
SGTC_1038 k292-0204 154 µM 0.264293386202384 0.389671794745738 no 1268 0.395776928099078 1786 4454212
SGTC_2463 5473429 200 µM 0.264205537246153 0.3897094283696 no 1269 0.395810772260843 1832 5399405
SGTC_2211 7117706 200 µM 0.26333701767527 0.39008154915937 no 1270 0.396145415134262 1930 822771
SGTC_953 1188-0045 9.7 µM 0.263304889169506 0.390095316684563 no 1271 0.396157795801603 1875 6144426
SGTC_1838 st055369 84.5 µM 0.263136340560133 0.390167544437598 no 1272 0.396222747449252 1883 676036
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.263128766221355 0.390170790340846 no 1273 0.396225666353108 1868 6708739 YPR165W RHO1
SGTC_3349 9149703 23.001 µM 0.262161469974205 0.39058537783135 no 1274 0.396598478627423 1861 4910494
SGTC_3288 9119690 36.221 µM 0.262116002003936 0.390604868671855 no 1275 0.396616005078611 1776 17595618 YKL019W RAM2
SGTC_3352 9151559 45.5865 µM 0.261335392930315 0.390939536666652 no 1276 0.39691693750767 1833 17159339
SGTC_3037 9091026 49.47 µM 0.260735165593765 0.391196925139417 no 1277 0.397148372777393 1888 25236398 YIL048W NEO1
SGTC_2212 7123476 200 µM 0.260261838874345 0.391399929918694 no 1278 0.397330903337571 1918 1085715
SGTC_1477 0139-0234 16 µM 0.259810826047714 0.391593392033343 no 1279 0.397504849839422 1888 620880
SGTC_1683 st010134 710 nM 0.259063301131203 0.391914102148383 no 1280 0.397793199916663 1767 3818134
SGTC_2336 9001819 198.65 µM 0.255672969833032 0.393369572745527 no 1281 0.399101684270643 1912 2989602
SGTC_3136 9095672 49.47 µM 0.254403920506754 0.393914760855425 no 1282 0.399591761229152 2016 17217380
SGTC_3298 9116858 71.43 µM 0.254354520336273 0.393935987556923 no 1283 0.399610841616136 1939 2506942
SGTC_690 glyoxal 20.3 µM 0.252861733913294 0.394577569563546 no 1284 0.400187530297513 1883 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2399 5884133 200 µM 0.252656756608452 0.394665688768102 no 1285 0.400266733529987 1813 722445
SGTC_2153 5569715 200 µM 0.252417950719906 0.394768357588854 no 1286 0.400359013300569 1876 2054701
SGTC_167 3672-0051 66.205 µM 0.251802248865628 0.395033097418906 no 1287 0.400596959487878 1825 3237971
SGTC_1103 duloxetine 36.1 µM 0.250707564745158 0.395503909929271 no 1288 0.40102010580902 1946 60835 A selective serotonin reuptake inhibitor.
SGTC_1149 3909-7961 23.3 µM 0.250627918365427 0.395538170988833 no 1289 0.401050897377176 1795 735261
SGTC_1262 0737-0114 49.6 µM 0.250552273464088 0.395570711501217 no 1290 0.401080142528944 1990 765919
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.250005835311103 0.395805796905978 no 1291 0.401291417989967 1932 688751
SGTC_2999 9069765 71.4286 µM 0.249742792283571 0.395918975249734 no 1292 0.40139313153693 1914 2097066
SGTC_2295 7971645 200 µM 0.249082818428159 0.396202977849095 no 1293 0.401648359800821 1910 2978226 YKL099C UTP11
SGTC_2429 5902844 64.44 µM 0.247716447452871 0.396791135045801 no 1294 0.402176902600876 1991 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3119 9125183 49.47 µM 0.246686775086848 0.397234514900226 no 1295 0.402575321135147 1980 22695334
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.246399779548964 0.397358119693277 no 1296 0.402686388436711 1973 6728940
SGTC_476 mead acid 10 µM 0.246293719044188 0.397403801015349 no 1297 0.402727435850686 1875 5312531 An omega 9 fatty acid.
SGTC_753 1322-0200 289 µM 0.245049139434645 0.397939958908178 no 1298 0.403209191613483 1895 5403907
SGTC_1364 1653-0028 37.6 µM 0.244318961771232 0.398254605141289 no 1299 0.403491899506003 1874 5718652
SGTC_464 bw-b 70c 158 µM 0.24358751490784 0.398569864637386 no 1300 0.403775149373409 1956 5353454
SGTC_1632 st005650 90 µM 0.241954501050011 0.399273945383295 no 1301 0.404407709362252 1875 2759605
SGTC_1553 gossypol 38.6 µM 0.241167930260661 0.39961319577048 no 1302 0.404712482672765 1934 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_192 3455-0609 60.9 µM 0.241063671864282 0.399658168430927 no 1303 0.404752884113652 1899 3769639
SGTC_951 1171-0579 82.7 µM 0.240500421126764 0.399901153973899 no 1304 0.404971168414634 1858 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1377 2944-0135 198 µM 0.239576654098122 0.400299749598935 no 1305 0.405329232539417 1874 1894137
SGTC_126 0417-1624 672.48 µM 0.238479350629963 0.400773359291705 no 1306 0.405754664607444 2025 41912 YDL195W SEC31
SGTC_2406 ethylparaben 405.7 µM 0.23766954407496 0.401122975381109 no 1307 0.40606870358732 1630 8434 A possible steroid mimic.
SGTC_1650 st011916 45.8 µM 0.235716375209551 0.401966538221638 no 1308 0.40682638116049 2002 242528
SGTC_1834 st055981 52.8 µM 0.235645649754621 0.401997092749974 no 1309 0.406853823697256 1988 471719 YDL150W RPC53
SGTC_1170 0310-0127 64.8 µM 0.235340577685766 0.402128895627325 no 1310 0.406972201472986 1920 774975
SGTC_413 propylparaben 100 µM 0.235152886159694 0.402209991122731 no 1311 0.407045036046212 1857 7175 A pharmaceutical preservative.
SGTC_3159 9100096 49.47 µM 0.23478066037184 0.402370830409502 no 1312 0.407189489508562 1920 25236875
SGTC_114 0364-0001 490.298 µM 0.234199254182477 0.402622089906057 no 1313 0.407415146998205 1840 4003655
SGTC_2440 5628896 157.78 µM 0.234108199902744 0.402661443412641 no 1314 0.407450490102074 1873 5522048
SGTC_571 k831-0106 44.2 µM 0.233244243809823 0.403034892806714 no 1315 0.40778587576363 2023 4783639
SGTC_840 0245-0196 390 µM 0.232325941487489 0.403431930618306 no 1316 0.408142432596968 1975 3827528
SGTC_2292 7671323 168.05 µM 0.232110070296545 0.403525279299195 no 1317 0.408226261743311 1880 937504
SGTC_853 0419-0306 21 µM 0.232016399761188 0.403565786742898 no 1318 0.408262638080153 1855 762713
SGTC_2664 lyso-paf C-16 73.48 µM 0.231544644902281 0.403769810937592 no 1319 0.408445852990392 1917 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_102 gallobenzophenone 83.616 µM 0.23141971689636 0.403823844097432 no 1320 0.408494374494575 1987 70837
SGTC_237 nikkomycin 200 µM 0.231077391716455 0.403971914064881 no 1321 0.4086273393195 1988 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2037 5169046 200 µM 0.23011639062141 0.404387660731286 no 1322 0.409000664379891 1934 5718022
SGTC_2013 4024628 200 µM 0.229447913141111 0.404676920042494 no 1323 0.409260399992628 1935 5230760
SGTC_2657 nystatin 74.44 µM 0.229072426297934 0.40483942117689 no 1324 0.409406312150316 1958 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1752 st044819 83.042 µM 0.227073672808336 0.405704706292648 no 1325 0.410183227703317 1858 441209 YML126C ERG13
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.225987238636702 0.406175230733289 no 1326 0.410605672849468 1978 688801
SGTC_204 PMA1.184 62.41 µM 0.224881594824468 0.40665421384768 no 1327 0.411035693899097 1922 2252213 YGL008C PMA1
SGTC_2095 5432005 200 µM 0.222474841636374 0.407697341044981 no 1328 0.411972128005794 1912 783734
SGTC_1125 tnp00248 1.32998 µM 0.222451180835118 0.407707599295074 no 1329 0.411981336591654 2040 24207736
SGTC_896 0964-0007 44.5 µM 0.221138164202106 0.408276962741371 no 1330 0.412492427512815 2040 6756758
SGTC_765 1319-0117 244 µM 0.220643669746521 0.408491440664949 no 1331 0.412684947696268 1862 3487746 YGL099W LSG1
SGTC_650 1328-0195 38 µM 0.220577135095428 0.408520300946362 no 1332 0.412710853055639 2014 2780821
SGTC_1881 5652484 16 µM 0.220526860712068 0.408542108451521 no 1333 0.412730427709227 2030 2255129
SGTC_1882 5615643 20 µM 0.219528311319374 0.408975307530156 no 1334 0.413119264220776 2024 2253075
SGTC_673 1082-0474 110 µM 0.219513461541123 0.408981750626096 no 1335 0.413125047389124 1875 3098046
SGTC_778 3456-2434 196 µM 0.217098562362745 0.41002986513759 no 1336 0.414065767159189 2046 5539063
SGTC_3305 9127027 53.8275 µM 0.215320948497713 0.41080179646565 no 1337 0.414758549059044 1924 41905295
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.214870486058186 0.410997465417792 no 1338 0.414934148074322 2025 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_133 0724-0033 378.92 µM 0.213092732155015 0.411769890346383 no 1339 0.415627316682161 2027 280309
SGTC_2638 epoxomicin 18 µM 0.212286350849823 0.412120371814097 no 1340 0.415941821606722 2034 9915668 A protesome inhibitor.
SGTC_3297 9117502 71.43 µM 0.212047071771487 0.412224384355207 no 1341 0.4160351556266 2052 7453720
SGTC_792 4534-1957 155 µM 0.211479478721105 0.412471136780724 no 1342 0.416256571854193 1937 1717904
SGTC_866 0495-0101 262 µM 0.21136530599647 0.41252077581506 no 1343 0.416301113480849 1838 635694
SGTC_1019 4262-0212 3.4 µM 0.209919344727034 0.413149559222026 no 1344 0.41686531184924 2061 4677213
SGTC_1854 st056233 32.9 µM 0.209915024037393 0.413151438430022 no 1345 0.416866997992595 2066 5393174
SGTC_819 1013-0258 27.7 µM 0.209893687445547 0.413160718434694 no 1346 0.41687532459146 1918 5753198
SGTC_1168 k815-0004 80.5 µM 0.209704344901804 0.413243072029272 no 1347 0.416949217098323 1930 642433
SGTC_1767 st044992 70.3 µM 0.208507171345978 0.413763864923874 no 1348 0.417416491882713 1897 9600693
SGTC_1609 st001574 46.4 µM 0.208418372065537 0.413802500327541 no 1349 0.417451156228151 1880 3960012
SGTC_2838 9002687 71.43 µM 0.208225861826977 0.413886261875272 no 1350 0.417526308154762 1848 6457060
SGTC_1893 st059353 36.1 µM 0.206773880231753 0.414518147609528 no 1351 0.418093227930282 1900 3112488
SGTC_562 3772-2733 112 µM 0.20630122077 0.414723891406179 no 1352 0.418277812504112 2027 2876874 YIL048W NEO1
SGTC_2165 5727197 32.143 µM 0.206291030747487 0.414728327275876 no 1353 0.418281792144568 1952 1361712
SGTC_3312 9133330 71.43 µM 0.205941744289327 0.41488038348246 no 1354 0.418418208529439 2023 17617324
SGTC_3158 9100007 49.47 µM 0.204063168266026 0.415698409350109 no 1355 0.419152068075968 1889 19297233
SGTC_1810 st050138 53 µM 0.204001645449103 0.41572520565807 no 1356 0.419176106534052 2054 3444541
SGTC_188 3229-0966 278.469 µM 0.20364743072434 0.415879491760049 no 1357 0.419314512692133 2055 5722370
SGTC_136 0097-0015 404.482 µM 0.203504318416502 0.415941831187974 no 1358 0.419370435347905 2075 4861337
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.203239221034579 0.416057312650795 no 1359 0.419474029270206 2024 94937 An inhibitor of serotonin biosynthesis.
SGTC_40 0327-0103 19.753 µM 0.203121624636986 0.416108542200043 no 1360 0.419519985008691 1906 409036
SGTC_470 aa-861 153 µM 0.202711981587613 0.416287009717062 no 1361 0.419680078828119 1903 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2648 atorvastatin 78.68 µM 0.202581912089819 0.416343680176946 no 1362 0.419730914457759 2037 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1248 0469-0687 58.6 µM 0.202199991739162 0.416510090510927 no 1363 0.419880189793712 1979 4017482
SGTC_1134 3477-0009 42.5 µM 0.200571787436454 0.417219699223266 no 1364 0.420516710057844 2092 3973534
SGTC_2470 5664817 21.68 µM 0.200369515213823 0.41730787297116 no 1365 0.420595799678731 2055 2859561
SGTC_3058 9093861 49.47 µM 0.200294715381351 0.417340480486822 no 1366 0.420625047662305 2008 17217477
SGTC_908 3448-7491 47.7 µM 0.198447269256157 0.418146018152925 no 1367 0.421347568619036 1935 1203031
SGTC_1086 cerivastatin 2.18 µM 0.197598377828215 0.418516273701288 no 1368 0.421679652043041 2059 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3097 9117246 49.47 µM 0.196735575336524 0.418892670739295 no 1369 0.422017234511374 2049 16423892
SGTC_1388 3346-4487 254 µM 0.19618310656039 0.419133723910172 no 1370 0.422233425070353 2018 3345614
SGTC_123 0083-0120 66.675 µM 0.195829557654339 0.419288000301097 no 1371 0.422371787154135 1861 16001701
SGTC_1063 disulfiram 1.84 µM 0.19369548430072 0.420219498060123 no 1372 0.423207163944889 2008 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2265 7929201 200 µM 0.193571583778499 0.420273592952074 no 1373 0.423255675086568 2011 1265108
SGTC_371 0195-0006 7.36 µM 0.192736902886225 0.420638053313451 no 1374 0.423582510475 1929 3928593
SGTC_603 3794-0023 45.9 µM 0.192641250850676 0.420679823776451 no 1375 0.423619968235188 2062 3802260
SGTC_1685 st024049 53.0905 µM 0.191803961826288 0.421045499132461 no 1376 0.423947883748637 1997 1941139
SGTC_1212 0520-0165 585 µM 0.189798036368116 0.421921838151826 no 1377 0.424733697339862 2093 5403258
SGTC_2921 7974240 10.71 µM 0.189690013352729 0.421969041738021 no 1378 0.424776023459401 2006 2979074 YDR527W RBA50
SGTC_147 4466-0538 29.23 µM 0.189114999344189 0.422220328553635 no 1379 0.425001342915921 1973 6742687 YHR072W ERG7
SGTC_2951 9072950 58.06 µM 0.188304378789831 0.422574631524474 no 1380 0.42531902649017 2101 16488155
SGTC_7 0192-1582 4.227 µM 0.188235196505044 0.422604872361838 no 1381 0.42534614139417 2004 252616
SGTC_323 4013-0906 34.3 µM 0.187115583331843 0.423094338986579 no 1382 0.425785005106224 2087 2910086
SGTC_3160 9100216 49.47 µM 0.186931418282793 0.423174862689708 no 1383 0.425857202571027 2106 17191039
SGTC_1244 0416-0015 52.5 µM 0.185507114357834 0.423797728660408 no 1384 0.42641565033069 1967 96201
SGTC_1335 1486-0900 202 µM 0.185425900349482 0.4238332503183 no 1385 0.426447497557338 2066 X1335
SGTC_2418 pentamidine 31.67 µM 0.184799072123201 0.424107435371078 no 1386 0.42669331783161 2104 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_403 arphamenine a 50 µM 0.184582773325876 0.424202056581664 no 1387 0.426778149325933 1996 5487158 An arginine aminopeptidase inhibitor.
SGTC_1980 st071811 45.7 µM 0.184406773967394 0.424279051784459 no 1388 0.426847178046275 2040 4974850
SGTC_3185 9108267 49.47 µM 0.184397842699206 0.424282959062167 no 1389 0.426850681039325 1934 4910486
SGTC_636 0kpi-0074 126 µM 0.183679287351311 0.424597339139202 no 1390 0.427132529367928 1971 616434
SGTC_2782 7736369 71.43 µM 0.182881154804165 0.424946591811284 no 1391 0.427445634902311 1954 2950836 YOL077C BRX1
SGTC_2666 tannic acid 100 µM 0.182569423052587 0.425083017684444 no 1392 0.427567938962982 2030 16134267 A thiamine antagonist.
SGTC_2097 5376186 200 µM 0.18211780361566 0.425280679730968 no 1393 0.427745138554578 2065 742755
SGTC_836 0330-0104 1.35 µM 0.181962494203337 0.425348658952188 no 1394 0.427806079878212 2088 46494820
SGTC_446 go6976 132 µM 0.181819696329619 0.425411163807943 no 1395 0.427862113362209 2109 3501 A protein kinase C inhibitor.
SGTC_3055 9094636 49.47 µM 0.181150284714499 0.425704200676765 no 1396 0.428124807974634 2035 25236176
SGTC_3144 9087057 49.47 µM 0.17954128755714 0.426408711399287 no 1397 0.428756350602091 2156 17249618
SGTC_312 4092-0653 6.84 µM 0.178841529253769 0.426715178917958 no 1398 0.429031067652712 2058 1148278
SGTC_3279 9140807 49.47 µM 0.177920487209302 0.42711862771912 no 1399 0.429392710540331 2091 45595718
SGTC_903 1134-0042 114 µM 0.177630850673479 0.427245514484003 no 1400 0.429506447246407 1958 701009
SGTC_3222 9128301 49.47 µM 0.177566699228327 0.427273619586006 no 1401 0.429531639521981 1996 4911358
SGTC_2075 5212009 200 µM 0.177094244004099 0.427480616186483 no 1402 0.429717181543708 2082 780898
SGTC_3254 9136651 49.47 µM 0.176155219953322 0.427892089603057 no 1403 0.430085999941241 2040 16454030
SGTC_1005 4092-0690 4.4 µM 0.175953803668513 0.427980358964912 no 1404 0.430165117727283 1953 1529343
SGTC_564 3555-0129 330 µM 0.175433822097744 0.428208254119966 no 1405 0.430369383237455 2108 563260
SGTC_1856 st057054 55.7 µM 0.175360698480092 0.428240304328401 no 1406 0.430398110045603 2100 1266018
SGTC_2314 7727897 200 µM 0.174779104932894 0.42849523462645 no 1407 0.430626603725107 1960 900724
SGTC_445 e6 berbamine 66 µM 0.173574249464347 0.429023454574095 no 1408 0.431100035372595 2002 6610268 A calcium/calmodulin antagonist.
SGTC_2112 5488546 200 µM 0.172856398839116 0.429338227527377 no 1409 0.431382152174478 2019 600757
SGTC_941 3237-0776 460 µM 0.17155053913308 0.429910953825686 no 1410 0.431895447448211 2085 760008
SGTC_1242 0402-0103 60.1 µM 0.171106170313672 0.430105879602437 no 1411 0.432070142107899 2043 432868
SGTC_221 trifluoperazine 10.304 µM 0.170274577274058 0.430470709977032 no 1412 0.43239710184103 2082 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2909 7941780 10.49 µM 0.169956986107571 0.430610056914906 no 1413 0.432521982267193 2121 1243215
SGTC_1992 st073643 23.3 µM 0.169000485382165 0.431029785223751 no 1414 0.432898129805715 2042 3161292
SGTC_2366 9070441 60.58 µM 0.16858265191151 0.431213161926543 no 1415 0.433062463506352 2007 6837235
SGTC_2857 9024691 58.44 µM 0.167687972715797 0.431605864160379 no 1416 0.433414379293613 1987 16478292
SGTC_217 ketoconazole 989 nM 0.167145014119984 0.431844218386731 no 1417 0.433627974011961 2066 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3035 9091303 49.47 µM 0.164989325656758 0.432790791372729 no 1418 0.434476191903253 2082 25237002
SGTC_2381 9035592 200 µM 0.164976107828981 0.432796596578888 no 1419 0.434481393774031 1941 4749657
SGTC_827 3253-0474 693 µM 0.164851469986669 0.432851337630666 no 1420 0.434530445504147 2119 5402065
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.163796958853146 0.433314531333565 no 1421 0.434945492914683 2057 97141
SGTC_997 3996-0078 137 µM 0.162914780628713 0.433702098266459 no 1422 0.435292766524187 2014 735687
SGTC_1659 st012954 42.1 µM 0.162190774729628 0.434020223077247 no 1423 0.435577812157126 2070 24207262
SGTC_1651 st011928 86.1 µM 0.161014343495212 0.434537232523855 no 1424 0.436041051784652 2063 720198
SGTC_815 1582-0027 36.9 µM 0.161010006558132 0.434539138697132 no 1425 0.436042759689465 2057 3128206
SGTC_1871 st057448 67.3 µM 0.16097839670588 0.434553031924971 no 1426 0.436055207823716 2090 691747
SGTC_2077 5212015 200 µM 0.157668266864003 0.436008351219175 no 1427 0.437359103523649 2130 780900
SGTC_514 4466-0038 2.65 nM 0.15714266957102 0.436239513614538 no 1428 0.437566204924329 2017 5722064
SGTC_530 4358-1714 28 µM 0.156802718983967 0.436389038530668 no 1429 0.437700164961255 2065 1564641
SGTC_1733 st037357 54.9 µM 0.155286185229877 0.437056185856343 no 1430 0.438297853047255 1932 1272339 YGL099W LSG1
SGTC_408 cantharidin 100 µM 0.153526051684021 0.437830720973094 no 1431 0.438991723780317 2040 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.152308344069676 0.438366704762358 no 1432 0.439471872043242 2152 1241132 A phosphatase inhibitor.
SGTC_2221 6807166 181.081 µM 0.151514785187418 0.438716056993716 no 1433 0.439784824293052 2111 674925
SGTC_834 0312-0008 75.7 µM 0.151510994389678 0.438717725949593 no 1434 0.439786319343381 2104 6385573 YIL048W NEO1
SGTC_1509 1326-1131 80 µM 0.151495656685752 0.438724478616193 no 1435 0.439792368379523 2132 768313
SGTC_3255 9139072 49.47 µM 0.150917195835174 0.438979168153777 no 1436 0.440020517769096 2040 17646060
SGTC_1204 4049-0315 18.3 µM 0.150752243969596 0.439051799162554 no 1437 0.440085579701137 2113 588402
SGTC_2980 9014342 25.29 µM 0.149806426640257 0.439468297572345 no 1438 0.440458669427329 2034 2996599
SGTC_1638 st008370 60.6 µM 0.149609601344664 0.439554979642905 no 1439 0.440536316335505 2132 24207134
SGTC_3325 9138760 55.175 µM 0.149461679055597 0.439620126684787 no 1440 0.440594672679389 2001 43844959
SGTC_764 1951-2361 146 µM 0.148957282315241 0.439842282336652 no 1441 0.440793670299123 1951 5438930
SGTC_1280 0880-0253 10.1 µM 0.148676668582152 0.439965883582588 no 1442 0.440904386184177 2038 6836607
SGTC_178 4092-0806 87.505 µM 0.148405883881442 0.440085161006165 no 1443 0.441011228413202 2144 2169044
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.148329102832109 0.440118983130541 no 1444 0.441041524327636 2108 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_923 1900-2434 73.3 µM 0.147768654504106 0.440365874365652 no 1445 0.4412626738994 2117 5910570
SGTC_1046 2001-0062 216 µM 0.147536513376231 0.44046814502295 no 1446 0.441354280773933 2014 739778
SGTC_2028 5153890 36.43 µM 0.147218864642685 0.440608092815024 no 1447 0.441479635500623 2045 2830968 YPR165W RHO1
SGTC_2092 5303694 80.6725 µM 0.147107221168618 0.440657281796431 no 1448 0.441523695111618 2015 1963699
SGTC_2387 9077560 195.08 µM 0.146715546641923 0.440829856853407 no 1449 0.441678273477309 1997 5303272
SGTC_515 4092-1064 102 µM 0.146562761380705 0.440897178359972 no 1450 0.441738574156017 2158 717353
SGTC_1845 st056753 3.01 µM 0.145383525227785 0.441416840478895 no 1451 0.442204035713778 2020 5375839
SGTC_1323 1348-1351 11.2 µM 0.144894207840677 0.441632501004919 no 1452 0.442397199824856 1997 6989654
SGTC_3228 9131799 49.47 µM 0.144387003049693 0.441856063445216 no 1453 0.442597439665832 2060 17015818
SGTC_2555 cholic acid 100 µM 0.143933046536749 0.442056171164833 no 1454 0.442776670008476 2058 6708657 Influences liver metabolism.
SGTC_1826 st055655 41.6 µM 0.142031178748553 0.442894690111455 no 1455 0.443527689124547 2030 676168
SGTC_708 3448-5400 146 µM 0.14154111433013 0.443110797366997 no 1456 0.443721241209658 2162 3462195
SGTC_1730 st033808 45.1 µM 0.140099771768245 0.443746494483924 no 1457 0.444290580458702 1987 1045166
SGTC_1613 st002381 52.1 µM 0.139857084434558 0.443853544835933 no 1458 0.444386454801647 2195 551167
SGTC_163 TUB2.036 7.546 µM 0.139496730727158 0.444012505851154 no 1459 0.444528819592318 2175 15992207 YJR013W GPI14
SGTC_2452 5863136 48.41 µM 0.137193041348591 0.445028932525882 no 1460 0.445439105551087 2134 2184096
SGTC_700 3453-2283 142 µM 0.137174594050037 0.445037073253611 no 1461 0.445446396033415 2135 565664
SGTC_97 0535-0701 19.132 µM 0.136742199439458 0.445227894100729 no 1462 0.445617286239336 2143 2832013 YGL099W LSG1
SGTC_2916 7875993 68.79 µM 0.136334502221696 0.445407827322309 no 1463 0.445778424842677 2201 1299250
SGTC_1259 0671-0132 43 µM 0.136000214403264 0.445555370408758 no 1464 0.445910555735191 2042 X1259
SGTC_2107 5363541 170.161 µM 0.135817914861635 0.445635834302916 no 1465 0.445982614141998 2179 244052
SGTC_3263 9137018 49.47 µM 0.135545385194147 0.445756128403772 no 1466 0.446090341566362 1971 43844957
SGTC_1316 1272-0050 65.9 µM 0.135333777117316 0.445849535269602 no 1467 0.446173990225212 2129 7340392
SGTC_1510 1123-0200 71.5 µM 0.135084819379001 0.445959432663917 no 1468 0.446272406269602 2139 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2998 9066762 71.4286 µM 0.134810335924131 0.446080602685031 no 1469 0.446380916778533 2133 4945196
SGTC_2189 6047310 154.431 µM 0.133760910698377 0.44654391510767 no 1470 0.446795819047756 2130 711535
SGTC_1353 1498-1206 8.11 µM 0.133720422361512 0.446561791834544 no 1471 0.446811827744767 2123 6756808
SGTC_511 blebbistatin 171 µM 0.13297141661888 0.446892518252603 no 1472 0.44710799298046 2156 3476986 A myosin inhibitor.
SGTC_1523 st012844 44.7 µM 0.132969263698649 0.446893468936309 no 1473 0.447108844311759 2052 4274103
SGTC_715 0868-0130 184 µM 0.132799862605126 0.446968273806415 no 1474 0.447175831511301 2191 2876258
SGTC_651 3253-0966 34.4 µM 0.132768063667437 0.446982315929745 no 1475 0.44718840610694 2091 781462
SGTC_1568 digitonin 820 nM 0.132553809386992 0.447076930414316 no 1476 0.447273132362693 2198 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2480 5767542 37.17 µM 0.132534126431329 0.447085622539793 no 1477 0.447280916053181 2119 2867358
SGTC_390 dec-rvkr-cmk 16.7 µM 0.131666021537749 0.447469008716228 no 1478 0.447624231183845 2098 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2862 9027634 71.43 µM 0.13153785560808 0.44752561554288 no 1479 0.447674921134599 2000 5012562
SGTC_2342 7990637 118.86 µM 0.131427423948978 0.44757439056189 no 1480 0.447718597821707 2076 2033102 YER133W GLC7
SGTC_2938 9059746 27.26 µM 0.131139693435496 0.447701477960534 no 1481 0.447832400732786 2111 6471769
SGTC_3099 9120367 49.47 µM 0.130396741222231 0.448029656568717 no 1482 0.448126272353453 2164 24824940
SGTC_1101 ebselen 5.29 µM 0.129286181112877 0.448520282070465 no 1483 0.448565602768488 2193 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1822 st052468 42 µM 0.126511278509125 0.44974652675896 no 1484 0.449663610909542 2120 2873678
SGTC_2488 5268135 45.7 µM 0.12632065521755 0.449830781991066 no 1485 0.449739053362418 2121 1270356 YLR208W SEC13
SGTC_2762 leflunomide 42.06 µM 0.126076523644804 0.449938691112194 no 1486 0.449835675292496 2072 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_487 nimodipine 119 µM 0.125551425488065 0.450170803410031 no 1487 0.450043507713707 2200 4497 L-type voltage-gated calcium channels inhibitor
SGTC_703 3875-0075 71.8 µM 0.12525275561943 0.450302833859561 no 1488 0.450161726551694 2104 2850814
SGTC_2946 9065502 71.43 µM 0.124625900111032 0.450579960414332 no 1489 0.450409861463583 2209 16489101
SGTC_568 1193-0097 7.48 µM 0.124536982251313 0.450619272065845 no 1490 0.45044506034196 2166 3646150
SGTC_2328 6201408 200 µM 0.124445568718617 0.45065968758932 no 1491 0.450481247559695 2078 2890418
SGTC_3197 9113331 49.47 µM 0.124393962792965 0.45068250369864 no 1492 0.450501676608148 2146 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1198 1612-1005 86.7 µM 0.124377921884356 0.450689595768656 no 1493 0.450508026690506 2168 6998509
SGTC_199 4063-0024 41.6 µM 0.124308606886576 0.450720241770851 no 1494 0.450535466425465 2167 306215
SGTC_943 3253-1379 105 µM 0.123959553039054 0.450874572212236 no 1495 0.450673649996777 2140 668464
SGTC_2347 9049783 174.81 µM 0.123102645583601 0.451253476167771 no 1496 0.451012908172066 2143 6467988 YPL169C MEX67
SGTC_117 lucigenin 22.078 µM 0.122942280203303 0.451324390843096 no 1497 0.451076402402415 1950 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_359 0081-0058 15.9 µM 0.122272499566156 0.451620589220243 no 1498 0.451341605360891 2166 3494159
SGTC_46 0329-0187a 2.197 µM 0.120695420760478 0.452318129896578 no 1499 0.451966143092102 2106 46494817
SGTC_1547 harmine 94.2 µM 0.120538838320918 0.452387394250728 no 1500 0.452028157693359 2179 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_11 0438-0307 1.3 µM 0.120057474790484 0.45260033481804 no 1501 0.452218809430744 2209 4011476
SGTC_1426 4048-4480 71.7 µM 0.11906059173615 0.453041368808264 no 1502 0.452613675921739 2190 14224343
SGTC_138 0850-0259 40.9225 µM 0.118550637278389 0.453267001704883 no 1503 0.45281568759665 2196 6813004
SGTC_574 1315-0397 40 µM 0.118077678169767 0.453476279239243 no 1504 0.453003054973427 2187 6794277
SGTC_2362 9071156 126 µM 0.116299374825286 0.454263267780311 no 1505 0.453707640534226 2172 653133
SGTC_2388 9080168 200 µM 0.113531531125173 0.455488533805853 no 1506 0.454804583227657 2108 15943073
SGTC_197 4544-0043 41.561 µM 0.113367958440532 0.455560957350992 no 1507 0.45486942068549 2211 896523
SGTC_3249 9135183 49.47 µM 0.113032840091263 0.455709339172408 no 1508 0.455002259709293 2146 4902779
SGTC_2794 7785382 27.27 µM 0.112433229421039 0.455974846821819 no 1509 0.455239954544299 2257 2205081
SGTC_1974 st069448 26.9 µM 0.112426936300834 0.455977633520377 no 1510 0.455242449318466 2211 6323587 YNR016C ACC1
SGTC_2250 alverine citrate 130 µM 0.110938395056125 0.456636844940166 no 1511 0.455832599326623 2118 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1674 st016616 23.6 µM 0.110883927297519 0.456660968661656 no 1512 0.45585419557828 2183 625830
SGTC_87 0100-0052 35.5 µM 0.108730728656226 0.457614745467411 no 1513 0.456708034198793 2191 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2927 9011802 47.9 µM 0.107493841318717 0.458162745511015 no 1514 0.457198605465161 2091 43912568
SGTC_2225 6654152 15.4 µM 0.107133694291677 0.458322322806289 no 1515 0.457341458403175 2193 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_3284 9108171 64.8615 µM 0.106422415867075 0.458637502378001 no 1516 0.457623604389324 2117 8687505
SGTC_1207 2099-0101 141 µM 0.105934705815076 0.458853630040872 no 1517 0.457817078863456 2210 5837381
SGTC_1575 cyproterone acetate 48 µM 0.103816334925358 0.459792521884655 no 1518 0.458657551560803 2103 9880 An androgen receptor antagonist and liver toxin.
SGTC_1160 4092-0570 10.5 µM 0.103657253998425 0.459863037912256 no 1519 0.458720675106676 2105 4994975
SGTC_3206 9114350 49.47 µM 0.103575596230178 0.459899234957253 no 1520 0.458753077433651 2229 17087243
SGTC_131 0141-0277 33.849 µM 0.102136470423525 0.460537221209254 no 1521 0.459324176578976 2201 1547771
SGTC_3010 9080089 71.4286 µM 0.102118189265056 0.460545326180472 no 1522 0.459331431771397 2215 17027233
SGTC_729 4092-0585 94.1 µM 0.101501622806529 0.460818691159081 no 1523 0.459576134700156 2136 2169061
SGTC_2145 5634607 200 µM 0.100351823213171 0.461328523268381 no 1524 0.460032508061824 2138 308662
SGTC_2027 5150920 200 µM 0.0986982380831231 0.462061849918166 no 1525 0.46068893392106 2199 786715
SGTC_2506 ethyl hematommate 54.16 µM 0.0985551083661747 0.462125330728859 no 1526 0.460745757376378 2039 3940691 An allergen.
SGTC_47 0149-0135 24.25 µM 0.0983929765479753 0.462197240506045 no 1527 0.460810125761231 2234 5239155
SGTC_2939 9044578 71.43 µM 0.0974567198157036 0.462612519386536 no 1528 0.461181851573293 2203 2653634
SGTC_3116 9124943 49.47 µM 0.097409453797245 0.46263348542488 no 1529 0.461200618694654 2088 41905195 YPL160W CDC60
SGTC_722 3534-0461 190 µM 0.0971881972069627 0.462731630762835 no 1530 0.461288470468315 2135 658262
SGTC_1439 4092-1168 46 µM 0.0971460658503495 0.462750319712004 no 1531 0.461305199288927 2207 2886240
SGTC_3219 9131112 49.47 µM 0.0962554031085921 0.463145425876315 no 1532 0.461658864861828 2255 17612988 YMR079W SEC14
SGTC_507 nimesulide 162 µM 0.0961837297454792 0.463177222423661 no 1533 0.46168732634023 2227 4495 A COX2 inhibitor.
SGTC_2636 apigenin dimethyl ether 100 µM 0.0949571697093576 0.463721399141469 no 1534 0.462174423378711 2163 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2910 7948405 25.97 µM 0.0946598822314194 0.463853304227736 no 1535 0.462292492088894 2211 2971328
SGTC_524 r073-0010 27.8 µM 0.0942430516826597 0.464038256712659 no 1536 0.462458043320118 2117 2772106
SGTC_969 1313-0238 134 µM 0.0939344193681022 0.464175205412554 no 1537 0.462580626003127 2160 5212874
SGTC_1883 5-benzylidenerhodanine 20 µM 0.0925928405999256 0.464770550159295 no 1538 0.463113515843724 2261 1273210
SGTC_1397 3532-0190 20.1 µM 0.0914777122575096 0.465265464379689 no 1539 0.463556507507384 2172 5322280
SGTC_3348 9149464 3.537 µM 0.0901062403461039 0.465874222135799 no 1540 0.464101395157892 2265 1951442
SGTC_1416 3966-0321 25.3 µM 0.089674333689313 0.466065949938834 no 1541 0.464273006249245 2194 582530 YLR208W SEC13
SGTC_2806 7952793 58.44 µM 0.0894978995195349 0.466144273148079 no 1542 0.464343111413448 2190 2972490
SGTC_1778 st046819 58.9 µM 0.0894086292752052 0.466183902774304 no 1543 0.464378582884653 2242 671715
SGTC_2333 9017922 200 µM 0.0892902407235118 0.466236459370868 no 1544 0.464425624932247 2230 3163164
SGTC_2736 butenafine 14.65 µM 0.0889131790150417 0.466403853462957 no 1545 0.464575454848719 2218 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2755 lomerizine 42.69 µM 0.087970887670555 0.466822203494343 no 1546 0.464949907342719 2186 3949 A calcium channel blocker.
SGTC_3008 9078912 71.4286 µM 0.0875838708270703 0.466994038395482 no 1547 0.465103711062368 2193 16648731
SGTC_1354 1498-1681 81 µM 0.087481400889618 0.467039535926167 no 1548 0.465144434343528 2154 5754243
SGTC_3126 9127922 49.47 µM 0.0872657037146259 0.46713530872766 no 1549 0.465230157230783 2182 45595682
SGTC_2213 7173844 200 µM 0.0872539288429629 0.467140537003231 no 1550 0.465234836874929 2241 892728
SGTC_2565 isoliquiritigenin 100 µM 0.085753020575692 0.467807016024702 no 1551 0.465831376496898 2016 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1820 st053765 18.6 µM 0.0854968595997828 0.467920773494071 no 1552 0.465933196004033 2158 3690829
SGTC_1307 1187-1599 12.2 µM 0.083551273591877 0.468784865590524 no 1553 0.466706604721999 2177 1538471
SGTC_1579 chlormadinone acetate 49.4 µM 0.0833711271641448 0.468864881430391 no 1554 0.466778222875837 2266 45114258 A steroidal progestin.
SGTC_331 k048-0133 24.5 µM 0.0833678256900856 0.468866347861554 no 1555 0.466779535404148 2257 6813582
SGTC_3046 9092212 49.47 µM 0.0811833778541631 0.469836715905796 no 1556 0.467648059214604 2255 25236637
SGTC_3261 9137475 49.47 µM 0.0811700137442253 0.469842653022884 no 1557 0.467653373185602 2266 17027690
SGTC_2891 9063876 19.48 µM 0.080470891171067 0.470153253364221 no 1558 0.467931373308474 2293 6472478
SGTC_17 0960-0276 49.807 µM 0.0796795909832569 0.470504827506885 no 1559 0.468246045935373 2280 6821114
SGTC_21 0849-0113 22.993 µM 0.079141100362621 0.470744091692081 no 1560 0.468460196326861 2239 1560156
SGTC_1215 3852-0577 11.2 µM 0.0789679169792402 0.470821043435382 no 1561 0.468529070944125 2241 2884876
SGTC_1032 k061-1018 98.7 µM 0.0789064549175628 0.470848353550775 no 1562 0.468553514485587 2272 4005393
SGTC_1470 k295-0292 231 µM 0.0787743610993106 0.470907048716976 no 1563 0.46860604876909 2252 5045612
SGTC_773 4358-1457 44.6 µM 0.0784820080213923 0.471036956454779 no 1564 0.468722320796581 2276 1186886
SGTC_1864 st057645 30.4 µM 0.0783536145032092 0.471094009373802 no 1565 0.468773385151484 2284 688666
SGTC_2096 5468907 200 µM 0.0782705778113219 0.471130907858213 no 1566 0.46880641057437 2248 759785
SGTC_686 1319-0111 510 µM 0.076779610825603 0.47179348120611 no 1567 0.469399435527001 2246 4562600
SGTC_1289 0976-0073 69.1 µM 0.0763486216485124 0.471985023844255 no 1568 0.469570872107599 2214 3391136
SGTC_2690 usnic acid 100 µM 0.0760261839701743 0.472128327653313 no 1569 0.469699133341555 2261 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2141 5621638 7.665 µM 0.0754012614471529 0.472406077715047 no 1570 0.469947727789515 2262 2856238
SGTC_1182 1222-0449 220 µM 0.0740640199481572 0.473000466553009 no 1571 0.470479722260935 2218 658318
SGTC_2879 9041815 71.43 µM 0.0739637126701669 0.47304505445282 no 1572 0.47051962961801 2284 4942971
SGTC_472 calcifediol 10 µM 0.0734806749090225 0.473259775788223 no 1573 0.47071181084304 2177 5283731 A vitamin D metabolite.
SGTC_3333 9141820 12.094 µM 0.0734132029516016 0.473289769236747 no 1574 0.470738655755049 2155 1939433
SGTC_880 0833-0487 87.2 µM 0.0732150640468755 0.473377849207765 no 1575 0.470817489592016 2284 76075
SGTC_1629 st005085 44.9 µM 0.0725033202885192 0.473694255976611 no 1576 0.471100681608643 2216 24207091
SGTC_1939 st074455 53.6 µM 0.0722272412842342 0.473816991795487 no 1577 0.471210533187203 2290 1644229
SGTC_407 eburnamonine 100 µM 0.0698648936379352 0.47486731577496 no 1578 0.472150597821264 2242 3195
SGTC_1953 st076800 12.1 µM 0.0698281529425311 0.474883652463264 no 1579 0.472165219528268 2073 297591
SGTC_3069 9117009 49.47 µM 0.0687953441745532 0.475342906319077 no 1580 0.472576262059861 2289 41904981
SGTC_3347 9188721 44.724 µM 0.0674955915700472 0.475920907224722 no 1581 0.473093585720897 2204 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2162 5663267 200 µM 0.0665844076408637 0.476326141650364 no 1582 0.473456279547901 2279 6456493
SGTC_2532 xanthone 78.9 µM 0.0662174834672406 0.476489332225303 no 1583 0.473602338764665 2261 7020 An insecticide.
SGTC_1446 4239-0190 62 µM 0.06611599588256 0.476534469815979 no 1584 0.473642737921739 2144 1340085
SGTC_1468 k284-1086 134 µM 0.065750997639422 0.476696808820274 no 1585 0.473788034989316 2237 15996457
SGTC_2276 7947513 42.08 µM 0.0656878856895405 0.476724879296552 no 1586 0.473813158700673 2038 2105100
SGTC_308 4092-1169 104 µM 0.0656735383050925 0.476731260638481 no 1587 0.473818870146184 2252 2268590 YDL196W YDL196W
SGTC_1400 3771-8998 51.5 µM 0.0653396231589707 0.476879779057557 no 1588 0.473951797506141 2241 670767
SGTC_1343 1487-0095 224 µM 0.0652382531527814 0.476924866936155 no 1589 0.473992152186988 2285 4560101 YGL055W OLE1
SGTC_273 hydroxyurea 18.1 mM 0.0651833883232737 0.476949270123631 no 1590 0.47401399359801 2301 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1485 3909-9022 254 µM 0.065080632941321 0.476994974660174 no 1591 0.474054900205735 2274 714516
SGTC_236 1509-0011 5.31 µM 0.064084719824219 0.477437962156345 no 1592 0.474451384324434 2275 3107280
SGTC_1105 epirubicin 18.1 µM 0.0624731400636023 0.478154860299831 no 1593 0.475093025635595 2271 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2156 5649887 115 µM 0.0619875076672997 0.478370903886052 no 1594 0.4752863901536 2259 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2847 9005661 71.43 µM 0.0619042525975201 0.47840794226069 no 1595 0.475319540456231 2309 2991449
SGTC_2210 7115885 190.385 µM 0.0617002989478073 0.478498677602749 no 1596 0.47540075094941 2278 2927039
SGTC_62 0180-0423 3.232 µM 0.0608459748022789 0.478878763238263 no 1597 0.47574093776391 2248 30102 YGL099W LSG1
SGTC_1163 k060-0048 49.9 µM 0.060833314525265 0.478884395893717 no 1598 0.475745979144813 2286 6809982
SGTC_3153 9100258 49.47 µM 0.0604451683571434 0.479057087176129 no 1599 0.47590054262584 2251 25236848
SGTC_1490 4089-0339 670 nM 0.0593949834751623 0.479524347716637 no 1600 0.476318754307162 2311 742542
SGTC_481 bay k-8644 50 µM 0.0592132679837337 0.47960520157216 no 1601 0.476391120931682 2209 2303 A calcium channel antagonist.
SGTC_2306 7482397 179.52 µM 0.0591978725447717 0.479612051773006 no 1602 0.476397252068052 2277 891448
SGTC_2716 st080858 38.6235 µM 0.0586433109357489 0.479858807970402 no 1603 0.476618106442224 2303 5296050
SGTC_1759 st043059 70 µM 0.0585977447335243 0.479879083325978 no 1604 0.476636253520042 2264 669426
SGTC_229 benomyl 22.8748 µM 0.0585640722435221 0.479894066431854 no 1605 0.476649663869935 2222 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_350 k064-0020 19.8 µM 0.0584874383102757 0.479928166015821 no 1606 0.476680184071354 2311 2790705
SGTC_2944 9067346 25.62 µM 0.0577284391218032 0.48026590362455 no 1607 0.476982470160737 2265 6473075
SGTC_2063 5246145 200 µM 0.0576694097447308 0.480292170969741 no 1608 0.477005980307854 2253 711240
SGTC_2290 7904846 200 µM 0.0575094643626354 0.480363345123025 no 1609 0.47706968355833 2250 2962154
SGTC_619 1652-1634 108 µM 0.0570184099089898 0.480581863523173 no 1610 0.477265265005598 2235 5400454
SGTC_2813 7971799 71.43 µM 0.0565016413969299 0.480811830936149 no 1611 0.477471093985098 2254 2234054
SGTC_2567 aureobasidin a 60 nM 0.0556717130677252 0.481181171086441 no 1612 0.477801667122236 2215 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1020 4335-0961 93.3 µM 0.0546451657270303 0.481638034233066 no 1613 0.478210577722239 2197 669075
SGTC_675 1309-0189 238 µM 0.0540286976344527 0.481912403936386 no 1614 0.478456150110781 2256 4246530
SGTC_2373 9071805 200 µM 0.0534591040347029 0.482165918960106 no 1615 0.478683057140645 2327 10149009
SGTC_862 0452-0056 10.2 µM 0.0533569236531151 0.482211398224789 no 1616 0.478723763118461 2296 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_553 k007-0256 45.7 µM 0.0525316867646843 0.482578709718428 no 1617 0.479052523897656 2257 6287000
SGTC_3027 9089541 49.47 µM 0.0521996397816854 0.482726507438551 no 1618 0.479184809978273 2257 9943819
SGTC_3111 9122088 49.47 µM 0.0513580116041996 0.483101135872618 no 1619 0.479520121238765 2317 16876704
SGTC_451 chloral hydrate 100 µM 0.0512369363888616 0.483155030524963 no 1620 0.479568359751316 2248 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_782 0083-0095 30.5 µM 0.0508976486037682 0.483306060571272 no 1621 0.479703539612755 2344 3591729 An indicator and reagent.
SGTC_234 nsc-17383 10.7 µM 0.0495350255030735 0.48391264044559 no 1622 0.48024646256708 2311 408974
SGTC_3223 9129970 49.47 µM 0.0488724513937028 0.484207602839136 no 1623 0.48051047161089 2314 17248386
SGTC_1348 1493-0373 93.8 µM 0.0488607558631868 0.484212809492053 no 1624 0.480515131884942 2278 3010129
SGTC_324 1315-0088 19.6 µM 0.0452203595441708 0.485833578893234 no 1625 0.481965833139516 2318 6787421
SGTC_892 0929-0076 29 µM 0.0451838793085431 0.48584982177424 no 1626 0.481980371787404 2327 5751038
SGTC_1961 st076550 68.7 µM 0.0451503468185637 0.485864752187672 no 1627 0.481993735676847 2290 1579337
SGTC_1652 st011932 78 µM 0.0448463518784146 0.486000107491449 no 1628 0.482114889389786 2324 1551076
SGTC_2126 5251174 33.877 µM 0.0440682896877675 0.486346550976333 no 1629 0.482424984690683 2319 790722
SGTC_435 c-PAF 6.7 µM 0.043699219990779 0.486510888235727 no 1630 0.482572080490816 2326 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1403 3909-7815 62.9 µM 0.0431206921360391 0.486768496433567 no 1631 0.482802662349838 2293 6615483
SGTC_2069 5228469 200 µM 0.0429256492364477 0.486855346828954 no 1632 0.482880401228482 2281 2835210
SGTC_565 1418-0001 44.5 µM 0.0428023529388863 0.486910249596476 no 1633 0.482929544168105 2330 2862145
SGTC_684 1140-0066 328 µM 0.0415805788053444 0.487454308220551 no 1634 0.483416527859207 2268 6813534
SGTC_557 1315-0110 16.2 µM 0.041372153926323 0.487547122622401 no 1635 0.483499605865756 2334 6833801
SGTC_2507 purpurin 79.67 µM 0.0397571102714801 0.488266345762679 no 1636 0.484143385110553 2345 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_999 SEC7.066 22.7 µM 0.0397329952054135 0.488277085156551 no 1637 0.484152998034382 2304 740511 YDR170C SEC7
SGTC_1704 st028805 70.8 µM 0.036780971268132 0.489591800144485 no 1638 0.485329823254744 2272 2876101
SGTC_2752 diclazuril 33.15 µM 0.0366451718529261 0.489652282676267 no 1639 0.485383962884745 2337 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2683 piperine 63.03 µM 0.0342364033407874 0.490725141588615 no 1640 0.486344318939146 2335 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_419 nsc-638432 893 µM 0.0339577374552093 0.490849263090796 no 1641 0.486455425936808 2271 368090
SGTC_2060 5238662 140 µM 0.0337957507305523 0.490921414546502 no 1642 0.486520012218732 2294 790130
SGTC_116 0155-0182 31.788 µM 0.0337324917069868 0.49094959119945 no 1643 0.486545234536825 2270 771486
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0335401550968032 0.491035261497856 no 1644 0.486621922347924 2357 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2016 5121758 140 µM 0.0331102587897861 0.491226746786665 no 1645 0.486793330952654 2360 2795203
SGTC_1022 4477-0945 21.3 µM 0.0322569946814744 0.491606815370187 no 1646 0.487133552307422 2347 4648966
SGTC_70 0141-0289 43.283 µM 0.0320127400112062 0.491715614903153 no 1647 0.487230945522813 2233 352408
SGTC_1931 st074438 57.1 µM 0.0317481382861626 0.491833478417864 no 1648 0.487336452707699 2353 2787313
SGTC_2965 9082772 38.63 µM 0.0316255258092285 0.491888094847933 no 1649 0.487385343458151 2348 16459634
SGTC_2729 fluphenazine 10.66 µM 0.0315507780838728 0.491921390505713 no 1650 0.487415148612482 2351 3372 An atypical antipsychotic.
SGTC_3315 9136395 68.55 µM 0.0310842896219997 0.492129184582247 no 1651 0.487601159340648 2349 16876844
SGTC_1718 roemerine 11.9335 µM 0.0298482772519499 0.492679767967688 no 1652 0.488094028110692 2349 235224 An aporphine alkaloid with mutagenic activity.
SGTC_430 0958-0115 16.4 µM 0.0297081563489337 0.492742185913538 no 1653 0.488149903484209 2223 6833180
SGTC_2190 6049624 200 µM 0.0275303944030889 0.493712308798562 no 1654 0.489018348900955 2334 2265554
SGTC_1205 4161-2785 76 µM 0.027424047905514 0.493759683740851 no 1655 0.489060759002404 2239 3498106
SGTC_209 4077-0173 175.592 µM 0.027159899554967 0.493877356193578 no 1656 0.489166099708515 2300 15993494
SGTC_1017 4239-0030 168 µM 0.0270406587432588 0.493930475605508 no 1657 0.489213652444657 2316 1149593
SGTC_1677 st019204 53.9 µM 0.0269328840234863 0.493978487193972 no 1658 0.489256632683313 2242 3945625
SGTC_422 cantharidin 155 µM 0.026776783989375 0.494048026945609 no 1659 0.489318885135104 2363 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1522 st012842 45.6 µM 0.0264325402574221 0.494201381959767 no 1660 0.48945616991963 2360 3491067 YOR116C RPO31
SGTC_1602 st001878 87.6 µM 0.025770102026358 0.494496489867809 no 1661 0.48972035452629 2344 595405 YLR310C CDC25
SGTC_1950 st077106 7.18 µM 0.0247861797663683 0.494934820382017 no 1662 0.490112757310944 2236 13831864
SGTC_2924 9010168 62.78 µM 0.0238574507890385 0.49534856829281 no 1663 0.490483156982432 2345 2993929
SGTC_1799 st045822 46.1415 µM 0.0236753309395896 0.495429703120112 no 1664 0.490555791773914 2374 3674992
SGTC_2803 7707263 71.43 µM 0.0233168529902865 0.49558940645066 no 1665 0.490698764313106 2358 2199229
SGTC_298 1391-0729 10 µM 0.023177524391071 0.495651478079518 no 1666 0.490754333364488 2349 3237558
SGTC_2721 ifenprodil 61.44 µM 0.0230578676848924 0.495704785859932 no 1667 0.490802056729636 2349 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2361 9034121 116 µM 0.0225235616396867 0.495942823330792 no 1668 0.491015158647676 2349 6496917
SGTC_3115 9123671 49.47 µM 0.0207602609392082 0.496728397203858 no 1669 0.491718449038903 2377 3286988
SGTC_602 3130-1533 38.1 µM 0.0206325629674649 0.49678528887491 no 1670 0.491769382249347 2368 720941
SGTC_591 4299-0174 154 µM 0.0200147233817661 0.497060548076272 no 1671 0.492015813679104 2347 5509088
SGTC_98 0074-0023 107.663 µM 0.0178267160805844 0.498035357003104 no 1672 0.492888545897045 2339 3563821
SGTC_1023 4482-3888 16 µM 0.0177402051396016 0.498073899949808 no 1673 0.492923053312168 2371 3303168
SGTC_60 0986-0278 202 µM 0.0166739590675118 0.498548942564442 no 1674 0.493348360963505 2338 3110598
SGTC_2651 TUB2.036 5 µM 0.016463871381938 0.498642542801244 no 1675 0.49343216231998 2359 15992207 YFL037W TUB2
SGTC_2537 larixol 68.93 µM 0.0163905848244866 0.498675194133766 no 1676 0.493461395481719 2372 6708759
SGTC_635 k038-0028 24.7 µM 0.0158731219209862 0.49890573942753 no 1677 0.493667806450561 2356 4035102
SGTC_705 1124-0212 310 µM 0.0145556610264454 0.499492709368441 no 1678 0.494193336438408 2384 9554485
SGTC_1557 sumaresinolic acid 42.3 µM 0.0122784256993394 0.499492709368441 no 1679 0.495101739928809 2381 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1123 mangostin 811.285 nM 0.0115350978665749 0.499161533406363 no 1680 0.495398263802687 2347 5281650 An antioxidant.
SGTC_783 0848-0141 92.7 µM 0.011413230317372 0.499107237623796 no 1681 0.495446878720304 2381 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_856 0433-0016 11.3 µM 0.0108107431115972 0.498838811102041 no 1682 0.495687221497684 2364 3911780
SGTC_275 trichlorophene 5.69 µM 0.0105410693054808 0.498718663316581 no 1683 0.495794799649751 2347 62616
SGTC_1187 1391-0724 117 µM 0.0103777917148572 0.498645918298568 no 1684 0.495859934421061 2365 6997986
SGTC_3211 9128781 49.47 µM 0.00995613943707522 0.498458059894621 no 1685 0.496028140647323 2339 17194361
SGTC_2425 5628681 7.85 µM 0.00984417970665418 0.49840817862071 no 1686 0.496072803928619 2378 5714958
SGTC_2963 9082507 9 µM 0.00978686974700228 0.498382645398079 no 1687 0.496095666193255 2386 16459611
SGTC_1832 st054113 55 µM 0.00959624386199694 0.498297716174164 no 1688 0.496171711347005 2390 1251267
SGTC_260 nsc-65238 3.989 µM 0.00938340109981439 0.498202888794365 no 1689 0.496256619500395 2384 3246252
SGTC_1035 k081-0041 55.2 µM 0.00937769843717159 0.498200348100669 no 1690 0.496258894433541 2386 731709
SGTC_1336 1486-0901 104 µM 0.00919757100032797 0.49812009639114 no 1691 0.496330751784581 2340 5006114
SGTC_2932 9016711 44.54 µM 0.00742914425205239 0.49733221835729 no 1692 0.497036227513526 2390 7117328
SGTC_1072 oxiconazole 14.9 nM 0.00729160092442907 0.497270939785581 no 1693 0.497091097875936 2391 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_937 3122-0005 46.7 µM 0.00613502792119846 0.49675566381281 no 1694 0.497552493324241 2385 759535
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.00606031618202474 0.49672237844355 no 1695 0.497582298441727 2390 75037 A free radical scavenger.
SGTC_1779 st039427 55 µM 0.00596327728056669 0.496679145972244 no 1696 0.497621010662778 2398 1124498
SGTC_3151 9099821 49.47 µM 0.00520218212970063 0.496340066606831 no 1697 0.49792463895893 2392 17174189
SGTC_245 methotrexate 289.6 µM 0.00508881231961707 0.496289558867376 no 1698 0.497969866370741 2343 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2460 5552655 174.22 µM 0.00464697642758475 0.496092715749209 no 1699 0.498146131299204 2372 5401989
SGTC_2869 9037858 32.47 µM 0.00411770103728261 0.495856918556382 no 1700 0.498357279600357 2401 27187042
SGTC_938 3126-1755 342 µM 0.00309216596730379 0.495400037174871 no 1701 0.498766406223457 2398 1777771
SGTC_124 0136-0217 7.121 µM 0.00237733545140118 0.495081579873616 no 1702 0.499051581267106 2401 3976905
SGTC_2082 5219693 150 µM 0.00215702076180205 0.494983430207405 no 1703 0.499139473885714 2402 2834649
SGTC_535 2293-4129 48.2 µM 0.00175322037722694 0.494803538896463 no 1704 0.49930056662298 2400 396118 YIL048W NEO1
SGTC_1041 0206-0046 107 µM 0.00140049311083932 0.494646401300434 no 1705 0.499441284267318 2395 50494
SGTC_595 3909-8003 73.7 µM 0.00110174109592622 0.494513309960274 no 1706 0.499560468983699 2400 699517
SGTC_1014 4130-3005 69.3 µM 0.00100255217864193 0.494469122322552 no 1707 0.499600039614632 2402 743608
SGTC_858 0438-0351 2.77 µM 0.000407005725894349 0.494203813977652 no 1708 0.499837628212058 2404 2799119
SGTC_1622 st003707 19.4 µM 2.04668864539039e-05 0.494031617222003 no 1709 0.499991834893646 2396 10140899
SGTC_334 1502-1024 68.5 µM 0 0.494022499588244 no 1710 0.5 2405 3296216
SGTC_1370 2001-0092 44.6 µM 0 0.494022499588244 no 1711 0.5 2386 790957
SGTC_2726 cimetidine 79.27 µM -0.000428855969709779 0.493831452609672 no 1712 0.499828911226725 2408 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1935 st074532 41.6 µM -0.000628475729760112 0.493742526375903 no 1713 0.499749274475698 2408 2829742
SGTC_95 0471-0001 561.058 µM -0.0010311138161168 0.493563160872214 no 1714 0.499588645175737 2407 4015405
SGTC_1281 0884-0031 11.8 µM -0.00154062160374305 0.493336189378087 no 1715 0.499385381147302 2411 1548255
SGTC_2437 5741531 144.16 µM -0.00161302863350983 0.493303934241274 no 1716 0.499356494957647 2413 2262990
SGTC_845 0330-0138 4.51 µM -0.0028129284465072 0.492769421781894 no 1717 0.498877805390851 2407 9039800
SGTC_1142 3253-1408 9.78 µM -0.00325855405287268 0.492570914764259 no 1718 0.498700027315892 2400 256655
SGTC_2933 9026794 32.47 µM -0.00350392511809914 0.492461613303389 no 1719 0.498602138983401 2413 17586027
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.00363404850067716 0.492403649583947 no 1720 0.498550227595075 2409 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2974 9094440 9.66 µM -0.00504059065934112 0.49177711307612 no 1721 0.497989103783122 2443 25236134
SGTC_2259 7964009 200 µM -0.00553588214797131 0.491556492942875 no 1722 0.497791513832068 2434 313134
SGTC_687 k029-0044 34.9 µM -0.00570472194925521 0.491481286383497 no 1723 0.497724157560628 2412 5829338
SGTC_2260 7964312 200 µM -0.0058342828828482 0.491423576072752 no 1724 0.497672471086621 2415 231951
SGTC_2397 5161689 200 µM -0.00646293869725376 0.491143556561439 no 1725 0.497421678447269 2424 2259942
SGTC_2595 hexamethylquercetagetin 100 µM -0.00672551392092918 0.49102660006991 no 1726 0.497316928366551 2422 386331
SGTC_2395 5646831 180.19 µM -0.00675416280117812 0.491013839306484 no 1727 0.49730549937652 2415 6808628
SGTC_1600 coumarin 106 71.1 µM -0.00714838601377143 0.490838245629225 no 1728 0.49714823086979 2471 100336 A hepatotoxic, DNA x-linker.
SGTC_3090 9117696 49.47 µM -0.00752414726038867 0.490670876875676 no 1729 0.496998327856065 2463 7923821
SGTC_1916 st067606 49.2 µM -0.00782054454005121 0.490538858981842 no 1730 0.496880085930044 2428 19590279
SGTC_552 k242-0005 476 µM -0.00801996119852577 0.490450037671914 no 1731 0.496800532688937 2435 4088318
SGTC_1283 0922-0125 16.4 µM -0.0119940482749517 0.488680061312871 no 1732 0.495215181751975 2431 3360884
SGTC_2409 alverine citrate 63.97 µM -0.01279549676868 0.488323138582808 no 1733 0.494895474630126 2532 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2934 9036370 36.88 µM -0.0131825259274605 0.488150779615809 no 1734 0.494741085360301 2453 6462800
SGTC_1055 3448-0672 86 µM -0.0132637413730456 0.488114611534723 no 1735 0.494708687917735 2462 748378
SGTC_341 1486-1430 230 µM -0.0146176032469405 0.487511704071358 no 1736 0.494168627696492 2437 2054753 YPL210C SRP72
SGTC_775 4577-0580 57.3 µM -0.0153480386478115 0.487186435271532 no 1737 0.493877258844251 2511 2006902
SGTC_1680 diphenhydramine 100 µM -0.0157259718527521 0.487018141886839 no 1738 0.493726503507687 2475 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_33 0986-0033 35.816 µM -0.0158414445980285 0.486966722416007 no 1739 0.493680442285256 2437 2848082
SGTC_2583 asiatic acid 100 µM -0.0160941569094913 0.486854191568423 no 1740 0.493579637511653 2461 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_891 0929-0073 133 µM -0.0168903837188169 0.486499644783684 no 1741 0.493262032177478 2488 5603632
SGTC_1108 betulinic acid 729.144 nM -0.0178934663616542 0.486053003700651 no 1742 0.492861920634542 2443 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2992 9074591 71.4286 µM -0.0188152430342076 0.485642581015425 no 1743 0.492494246896398 2437 17741321
SGTC_2359 9039622 200 µM -0.0208869004687369 0.484720228055791 no 1744 0.491667938128734 2455 6463596
SGTC_979 1426-2828 121 µM -0.0228271947489501 0.483856435253301 no 1745 0.490894057700534 2497 747872
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0231450218401704 0.483714950039356 no 1746 0.490767296528787 2448 165506
SGTC_2882 9058044 58.44 µM -0.0231969677750866 0.483691825767999 no 1747 0.490746578661462 2469 18076804
SGTC_3321 9137793 26.8275 µM -0.0232962115759005 0.483647646513962 no 1748 0.490706996809805 2452 4904192
SGTC_1363 1636-0063 10.4 µM -0.023413156330873 0.483595587781628 no 1749 0.490660355324432 2449 6072185
SGTC_319 1348-1596 45.5 µM -0.0234346603830237 0.483586015140781 no 1750 0.490651778802033 2466 5380505
SGTC_2420 aureobasidin a 50 nM -0.024880523299899 0.482942403713898 no 1751 0.490075131290235 2471 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1623 st003709 20.3 µM -0.0249640028088176 0.482905244985972 no 1752 0.490041838125708 2450 16192618
SGTC_665 3914-0008 307 µM -0.0249658775896242 0.482904410477856 no 1753 0.490041090429414 2462 1069549
SGTC_1234 0326-0494 15.5 µM -0.0250863884394729 0.482850768480359 no 1754 0.489993028609283 2481 1547813
SGTC_3201 9113999 49.47 µM -0.0255117224816911 0.482661445545186 no 1755 0.489823399171514 2497 16649224
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.0255741570645642 0.48263365524913 no 1756 0.489798499500768 2471 5377381
SGTC_198 3454-2873 16.191 µM -0.0268467729098585 0.48206721899584 no 1757 0.489290973629765 2451 710957
SGTC_216 k038-0035 28.382 µM -0.0279225001632122 0.481588445257152 no 1758 0.488861981451605 2445 4444231 YPR107C YTH1
SGTC_1345 1488-0192 31.4 µM -0.0287218054069896 0.481232715770565 no 1759 0.488543232670303 2462 658348
SGTC_981 1488-1094 54.9 µM -0.0297189079088406 0.480788977919239 no 1760 0.488145616125441 2459 3449522
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.0300295615946621 0.480650733380376 no 1761 0.488021738526952 2454 2724 A muscle relaxant with antifungal properties.
SGTC_3061 glucosamine 200 µM -0.0305732198398187 0.480408804685744 no 1762 0.487804949817296 2442 91431 and experimental redox chemotherapeutic
SGTC_1911 st060208 74.3 µM -0.0308299595231593 0.480294557663498 no 1763 0.487702573763407 2495 688783
SGTC_736 0958-0254 92.6 µM -0.03155204347901 0.479973245021649 no 1764 0.48741464404407 2494 6812352
SGTC_1567 st069303 68.4 µM -0.0344338931144716 0.478691012343903 no 1765 0.486265578346023 2487 5581319
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.034438259118812 0.478689069924389 no 1766 0.486263837594731 2498 4213774
SGTC_201 4262-0159 12.803 µM -0.0344386471521643 0.478688897289781 no 1767 0.486263682883592 2465 1341029
SGTC_492 tmb-8 126 µM -0.0352653436687926 0.478321112186842 no 1768 0.485934078938853 2460 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1294 1000-1494 117 µM -0.0385371466279791 0.476865719371217 no 1769 0.484629707371693 2479 712797 YDL207W GLE1
SGTC_807 1315-0151 48 µM -0.0399170707045406 0.476251980515489 no 1770 0.484079620747585 2479 4011080
SGTC_1444 4112-3581 28 µM -0.0401698195338818 0.476139573306932 no 1771 0.483978869362186 2471 2877249
SGTC_1740 st038286 13.222 µM -0.0412340624880717 0.475666284117994 no 1772 0.483554649408286 2517 716786
SGTC_71 0417-1750 47.813 µM -0.0415493513574773 0.475526075691778 no 1773 0.483428975051652 2471 6811472
SGTC_3096 9117468 49.47 µM -0.0417180552589679 0.475451054596019 no 1774 0.483361730237732 2470 41316311
SGTC_2516 gossypol 71.55 µM -0.0418438267955324 0.475395125699902 no 1775 0.483311598429481 2511 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3190 9110366 49.47 µM -0.0423352776543597 0.47517658882848 no 1776 0.483115711491825 2480 17123768
SGTC_1482 3346-2049 8.48 µM -0.0423628601223362 0.475164323761326 no 1777 0.483104717542088 2552 3826804
SGTC_2914 7968218 45.32 µM -0.0424193679433568 0.475139196561232 no 1778 0.483082194429297 2516 2977111
SGTC_2588 indole-3-carbinol 100 µM -0.0427876336655453 0.474975443133746 no 1779 0.482935410933886 2526 3712 Induces cell cycle arrest.
SGTC_1896 st058441 89 µM -0.043835191828672 0.474509658015011 no 1780 0.482517887505825 2510 688759
SGTC_1819 st053448 58.6 µM -0.0439431006143907 0.47446167953875 no 1781 0.482474879570921 2492 2857616
SGTC_3015 9080845 49.47 µM -0.0445256338356291 0.47420267964373 no 1782 0.482242709694646 2533 5296973
SGTC_2958 9077254 16.72 µM -0.0446305680634952 0.474156026028519 no 1783 0.482200888568778 2540 16457351
SGTC_31 0508-1974 57.237 µM -0.045097862481667 0.473948271877164 no 1784 0.482014652591695 2483 6810525
SGTC_2703 st077852 53.4 µM -0.0451053330668744 0.473944950591455 no 1785 0.482011675289083 2523 6281836
SGTC_1495 4469-0029 237 µM -0.0456310765781223 0.473711219192563 no 1786 0.481802149717724 2485 793680
SGTC_1698 5-fluorocytosine 1.055 µM -0.0476760571759914 0.472802162714138 no 1787 0.480987208002099 2498 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_527 4476-4215 268 µM -0.0492627570058506 0.472096923405633 no 1788 0.480354949533439 2530 4418754
SGTC_249 wiskostatin 11.211 µM -0.0496420528952734 0.471928350911561 no 1789 0.480203817280313 2484 2775510 A n-wasp and actin depolymerizer.
SGTC_1946 st076057 65.1 µM -0.0499468016893665 0.471792913422242 no 1790 0.48008239073292 2502 953009
SGTC_2754 granisetron 64.02 µM -0.0510274044614559 0.471312694680469 no 1791 0.479651841693017 2526 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2168 5727979 200 µM -0.0525344467352028 0.470643036465992 no 1792 0.479051424346999 2491 695210
SGTC_872 0588-0139 234 µM -0.0527386999005008 0.470552282378168 no 1793 0.478970051927286 2512 2047100
SGTC_2863 9028737 58.44 µM -0.05301964964613 0.470427452844781 no 1794 0.478858125789228 2561 6460917
SGTC_2205 7238770 200 µM -0.0533739901489371 0.470270019012915 no 1795 0.478716964259735 2542 279867
SGTC_2064 5220758 200 µM -0.0537934266743667 0.4700836689624 no 1796 0.478549873346155 2585 788518
SGTC_3302 9125395 16.351 µM -0.0546306624833955 0.469711715898053 no 1797 0.478216355049357 2532 17599668
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.0553640855713941 0.469385904711099 no 1798 0.477924203747595 2564 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1369 1866-0067 208 µM -0.0568477972102997 0.468726853036445 no 1799 0.47733321940235 2478 3531355
SGTC_3339 9145883 14.936 µM -0.0577828841737193 0.46831153952769 no 1800 0.476960785923981 2524 2030670
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.0583424786118192 0.468063015334064 no 1801 0.476737916040285 2502 5355888
SGTC_2917 7979103 53.79 µM -0.0585095265704075 0.46798882926482 no 1802 0.476671387195145 2560 2980565
SGTC_1159 4092-0538 61.2 µM -0.0589975939744058 0.467772084702182 no 1803 0.476477012252912 2495 717301
SGTC_2799 7812892 81.82 µM -0.0605843938397527 0.467067473302909 no 1804 0.475845101301495 2557 20205235
SGTC_1841 st054148 70 µM -0.0618319375418043 0.466513579431363 no 1805 0.47534833482914 2570 675442
SGTC_3104 9120930 49.47 µM -0.0623891068183602 0.46626622409415 no 1806 0.475126484780555 2572 17014836
SGTC_170 4197-0004 226 µM -0.0630897006360747 0.465955213926669 no 1807 0.474847537831639 2590 218692
SGTC_2459 5811157 9.22 µM -0.0632470104399621 0.465885383235232 no 1808 0.474784905383834 2508 2870684 YBR192W RIM2
SGTC_3092 9117248 49.47 µM -0.0643272431371478 0.465405890453571 no 1809 0.474354830743039 2511 17141857
SGTC_3189 9110682 49.47 µM -0.0648137960245452 0.465189936129746 no 1810 0.47416112845422 2565 17122418
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.0658611389493996 0.464725112522431 no 1811 0.473744190000836 2504 4174840
SGTC_1106 tegaserod maleate 11.7 µM -0.0663385829987363 0.464513232944853 no 1812 0.473554133036329 2571 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2700 st077718 96.8 µM -0.067254379747547 0.46410684991687 no 1813 0.473189597151103 2579 904970
SGTC_1132 3456-3614 2.5 µM -0.0686538892968707 0.463485892748502 no 1814 0.472632561281515 2635 3125502
SGTC_2551 apiole 73.87 µM -0.0690145138813531 0.463325899317761 no 1815 0.472489033319596 2516 10659 A possible DNA adduct former.
SGTC_1186 1319-0216 26 µM -0.0697021139236357 0.463020857567946 no 1816 0.472215379604294 2623 4565136
SGTC_1374 2889-5571 141 µM -0.0699912584340213 0.462892590139548 no 1817 0.472100308667185 2584 2853281
SGTC_536 3852-0578 10.6 µM -0.0700655163209493 0.46285964921219 no 1818 0.472070756606637 2616 2869208
SGTC_51 1013-0126 23.419 µM -0.0704007915797738 0.462710923700418 no 1819 0.471937330612012 2522 1627850
SGTC_2972 9093619 59.92 µM -0.070773549033251 0.462545577497173 no 1820 0.471788991917431 2539 25236256
SGTC_411 enrofloxacin 100 µM -0.0714725576271092 0.462235531636958 no 1821 0.471510832264812 2567 71188 A bacterial gyrase inhibitor.
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.0714772261746485 0.462233460975626 no 1822 0.471508974535131 2560 390807
SGTC_2238 6671620 73.2395 µM -0.0734792867734842 0.461345573341323 no 1823 0.470712363135983 2521 729941
SGTC_2707 st078556 66.6 µM -0.0737241300475295 0.461237001689726 no 1824 0.470614949016245 2567 17250899
SGTC_2279 7948423 32.93 µM -0.0746487874545603 0.460827003964602 no 1825 0.470247077802538 2524 1247112
SGTC_3192 9110362 49.47 µM -0.0752472795026369 0.460561651763022 no 1826 0.470008983675657 2532 16649480
SGTC_1907 st060210 83.7 µM -0.0753750906547365 0.460504986664178 no 1827 0.469958138798201 2539 688793
SGTC_309 k408-0051 1.48 µM -0.0755558661440715 0.460424841185952 no 1828 0.469886224880435 2555 3640463
SGTC_3251 9135047 49.47 µM -0.0755600425090717 0.460422989644358 no 1829 0.469884563501044 2642 17682963
SGTC_500 h-89 112 µM -0.0767206797764635 0.459908468358567 no 1830 0.469422876471919 2636 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1089 terbinafine 2.25 µM -0.0770483256334093 0.459763232018699 no 1831 0.469292550450302 2605 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_425 3825-7017 13.1 µM -0.0789191471635377 0.4589340520436 no 1832 0.468548466753224 2773 3397440
SGTC_728 3030-5151 22.5 µM -0.0790350183190719 0.458882701810857 no 1833 0.468502384789912 2548 3125388
SGTC_235 0330-0087 5 mM -0.0791625760341845 0.45882617327795 no 1834 0.468451655569402 2556 46494818 YHR062C RPP1
SGTC_1073 triclabendazole 3.09 µM -0.0799072690656617 0.458496171443242 no 1835 0.468155504220631 2584 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2746 daunorubicin 9.88 µM -0.0800712874561328 0.458423492485548 no 1836 0.468090279347761 2522 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3187 9109394 49.47 µM -0.0804577623283203 0.458252245294033 no 1837 0.467936594030749 2587 17098090
SGTC_2326 6164455 177.58 µM -0.0805000841543661 0.458233492943831 no 1838 0.467919764654035 2595 2888790
SGTC_2978 9011784 42.97 µM -0.0812470955390195 0.45790251549757 no 1839 0.467622723231038 2706 2994934
SGTC_2119 5528445 120.635 µM -0.0812919829443152 0.457882628215682 no 1840 0.46760487478679 2637 791935
SGTC_3329 9141233 27.5565 µM -0.0818872145544792 0.457618921940902 no 1841 0.467368200799902 2650 4909101 YNL103W MET4
SGTC_2426 5582046 32.21 µM -0.082866335821223 0.457185181146274 no 1842 0.466978911034936 2633 2251934
SGTC_1141 3253-0389 52.6 µM -0.0851655371586121 0.456166859642141 no 1843 0.466064894185336 2539 5402031
SGTC_1865 st057639 52.2 µM -0.0851704924808779 0.456164665227092 no 1844 0.466062924454552 2549 688818
SGTC_2172 5754775 163.918 µM -0.0854129348387997 0.456057303680922 no 1845 0.465966555113805 2581 2263357
SGTC_2115 tiliquinol 12.7705 µM -0.0856639818368586 0.455946135094918 no 1846 0.465866767584851 2641 71208 A bioactive hydroxyquinoline.
SGTC_605 1315-0399 119 µM -0.087157687896572 0.455284764048384 no 1847 0.465273085742168 2654 24020461
SGTC_1197 1601-0112 267 µM -0.0874687565480166 0.455147047124027 no 1848 0.465149459443422 2551 7350313
SGTC_513 4245-1575 41.7 µM -0.0881709233568864 0.454836202296296 no 1849 0.464870413544784 2711 719745
SGTC_2158 5657123 3.6195 µM -0.0882966177277819 0.454780561101964 no 1850 0.464820463560046 2529 2858827
SGTC_174 3553-0389 74.3 µM -0.0885963000682784 0.454647904141479 no 1851 0.464701374320563 2658 738071
SGTC_3291 9121177 71.43 µM -0.0886121571299208 0.454640885017795 no 1852 0.464695073051557 2605 17015612
SGTC_1218 1348-1416 30.7 µM -0.088817480386784 0.454550000018173 no 1853 0.464613482627286 2552 6787668
SGTC_365 0121-0052 13.6 µM -0.0897935062054569 0.454118001178395 no 1854 0.464225654321248 2624 3101739
SGTC_1463 k081-0032 34.1 µM -0.0903617235664308 0.453866527424572 no 1855 0.463999886193678 2570 977755
SGTC_271 rotenone 740 µM -0.0904079602167025 0.453846065461909 no 1856 0.463981515630864 2697 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_452 diindolylmethane 8 µM -0.0909552496852938 0.453603872621761 no 1857 0.463764074590898 2647 3071 Inhibits expression of several cancer promoting factors.
SGTC_881 0833-0569 170 µM -0.0915119152328729 0.453357548271424 no 1858 0.46354291948829 2572 5418700
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.0918811056146755 0.453194191520896 no 1859 0.463396251743804 2609 676296 Flavone; oxidizing agent.
SGTC_1313 1220-0047 237 µM -0.0930839427769491 0.452662023716391 no 1860 0.462918436926709 2616 3528706
SGTC_2773 thioridazine 9.09 µM -0.0931231434858086 0.452644681684315 no 1861 0.462902865740607 2549 5452 An antipsychotic.
SGTC_2457 5731572 11.68 µM -0.0937247182394773 0.452378561910671 no 1862 0.462663917193935 2622 2865357
SGTC_1257 0669-0121 16 µM -0.0940148529925262 0.452250222084544 no 1863 0.462548679007162 2665 4307855
SGTC_1731 st035964 63 µM -0.0956434215096736 0.451529924974763 no 1864 0.461901888938991 2639 6739575
SGTC_321 4534-3890 65.3 µM -0.0967590809513507 0.451036573587193 no 1865 0.461458860036027 2637 699746
SGTC_1833 st055984 71 µM -0.0984949581146814 0.450269108808608 no 1866 0.460769637667968 2622 676288
SGTC_2132 5317594 122.667 µM -0.099450061579279 0.449846918254219 no 1867 0.460390468171701 2593 794577
SGTC_746 1095-0025 46.6 µM -0.0997814131445584 0.449700462018613 no 1868 0.460258932279723 2648 6749286
SGTC_3355 9151058 44.0485 µM -0.100331916950831 0.449457156413423 no 1869 0.460040409632773 2577 17015728
SGTC_2104 5389443 200 µM -0.10074562324664 0.449274323564627 no 1870 0.459876196737277 2699 2244536
SGTC_2378 9074213 121.43 µM -0.101128466546549 0.449105139863566 no 1871 0.459724240421387 2594 657714
SGTC_929 2805-0021 398 µM -0.103519935176483 0.448048527731427 no 1872 0.458775164254382 2679 3098024
SGTC_1410 3909-8106 77.9 µM -0.103810488802661 0.44792017864783 no 1873 0.45865987129245 2651 1039210
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.104681686717504 0.447535368642757 no 1874 0.458314196996582 2569 2346 DNA damaging agent; causes G2/M arrest.
SGTC_499 genistein 192 µM -0.104862019866943 0.447455721256537 no 1875 0.458242648258766 2603 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3276 9139060 49.47 µM -0.105246621928583 0.447285861905093 no 1876 0.458090058584813 2578 4870619
SGTC_2345 9052315 157.45 µM -0.105497379288432 0.447175120219113 no 1877 0.457990574705637 2671 6469265
SGTC_2031 5180455 200 µM -0.105732158679128 0.447071438598345 no 1878 0.457897432209686 2597 29949
SGTC_2885 9057732 51.95 µM -0.105981414075655 0.446961368144723 no 1879 0.457798549272848 2704 6471414
SGTC_1741 st038134 10.228 µM -0.106077951925522 0.446918738409882 no 1880 0.457760252122973 2711 1272587
SGTC_1239 0337-0584 35.4 µM -0.106680251689769 0.446652785311163 no 1881 0.457521325027908 2710 914301 YML130C ERO1
SGTC_391 gliotoxin 8.33 µM -0.108335459660454 0.44592203116149 no 1882 0.456864797695496 2711 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1074 carmofur 3.8 µM -0.108401276352268 0.445892977674253 no 1883 0.456838694360177 2585 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_933 2914-0560 114 µM -0.109970946802835 0.445200163886103 no 1884 0.456216208113695 2657 463887
SGTC_826 1683-5028 118 µM -0.11037430400716 0.445022158914424 no 1885 0.456056265515617 2675 722377
SGTC_34 0469-0683 81.75 µM -0.111069295306117 0.444715479355891 no 1886 0.455780698427094 2678 3690923
SGTC_2809 7964133 12.99 µM -0.111425765833961 0.444558192049905 no 1887 0.455639364549052 2649 1253665
SGTC_149 3970-0822 46.1 µM -0.11157668226476 0.44449160505363 no 1888 0.45557953070532 2589 3114250 YBL034C STU1
SGTC_3021 9087658 49.47 µM -0.111713181940678 0.444431380333565 no 1889 0.455525413540717 2603 25237042
SGTC_1075 aripiprazole 15.2 µM -0.111884486097376 0.444355801420998 no 1890 0.455457498831168 2592 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1162 k048-0130 20.1 µM -0.112094050341187 0.444263345017371 no 1891 0.455374417417693 2607 6797406
SGTC_1503 4585-0012 61.3 µM -0.113928653261995 0.443454077500049 no 1892 0.454647175713172 2802 2922052
SGTC_1773 st048542 73.5835 µM -0.114477751996709 0.443211908507102 no 1893 0.454429540889237 2602 3237138
SGTC_266 formosanin C 406 nM -0.114585909570203 0.443164210274342 no 1894 0.454386674336138 2626 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_3042 9091578 49.47 µM -0.114588639405289 0.443163006408973 no 1895 0.454385592415809 2585 25236497
SGTC_1796 st049173 110.4 µM -0.116194424080506 0.442454941903121 no 1896 0.453749227880226 2592 94134
SGTC_3282 9108498 15.4605 µM -0.116631776385935 0.442262124854375 no 1897 0.453575927825035 2707 16459645
SGTC_2414 st077232 92.9 µM -0.116817757013709 0.442180135063208 no 1898 0.453502236016546 2600 729801
SGTC_802 4112-3352 742 µM -0.117511879603314 0.441874152155827 no 1899 0.453227215352546 2765 704594
SGTC_662 k832-1615 104 µM -0.117588859279296 0.441840220131679 no 1900 0.453196716353631 2689 5878478
SGTC_1760 st045453 10.4495 µM -0.118164969899539 0.441586288753932 no 1901 0.452968472712251 2634 3323419 YIL048W NEO1
SGTC_270 tamoxifen 5.46 µM -0.120850905847371 0.440402731489564 no 1902 0.451904564257948 2705 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1255 0566-0045 221 µM -0.122273249725753 0.439776190762678 no 1903 0.451341308319314 2737 2788469
SGTC_762 1165-0429 115 µM -0.122862642802415 0.439516607940009 no 1904 0.451107934083903 2690 5967793
SGTC_1578 josamycin 24.2 µM -0.123054915063262 0.439431932252504 no 1905 0.451031806213829 2637 5282165 A P450 substrate.
SGTC_3239 9133757 49.47 µM -0.125140418973619 0.438513666192597 no 1906 0.450206192536154 2616 17036923
SGTC_1408 3909-7976 48.8 µM -0.126163501099681 0.438063314636437 no 1907 0.449801251179312 2658 24152374
SGTC_1435 4092-0789 56.7 µM -0.127585347780908 0.437437563815703 no 1908 0.449238563568069 2645 2248285
SGTC_1800 st050079 29.0735 µM -0.129281807209039 0.436691161495877 no 1909 0.448567333181696 2697 3645560
SGTC_2407 paclitaxel 400 µM -0.129946859045857 0.436398615637605 no 1910 0.44830423520475 2912 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_646 4092-0839 27.3 µM -0.131633003370663 0.435657063490081 no 1911 0.447637289871036 2743 877796
SGTC_2057 5236571 38.335 µM -0.131694227590053 0.435630141831001 no 1912 0.44761307573332 2711 54684039 YBR257W POP4
SGTC_1308 1187-1617 41.4 µM -0.137153425452241 0.433230824041838 no 1913 0.445454762012153 2624 2882570
SGTC_2570 licareol 100 µM -0.137229468342964 0.433197420346867 no 1914 0.445424709440011 2772 443158
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.137415073488354 0.433115890763057 no 1915 0.445351358574422 2621 2333 A French combination drug.
SGTC_1558 st069300 45.6 µM -0.139205732822998 0.43232946601638 no 1916 0.444643789238282 2661 24208000
SGTC_2717 st081029 62.2815 µM -0.139616775616289 0.432148981269569 no 1917 0.444481392711612 2694 5292846
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.140051877157204 0.431957947996478 no 1918 0.444309501107262 2686 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2549 cedrol 20.94 µM -0.140612342001976 0.431711896856458 no 1919 0.444088098804125 2739 6708665 A sedative which affects the nervous system.
SGTC_2243 6634756 200 µM -0.140800435459142 0.431629327387312 no 1920 0.444013799523226 2939 885676
SGTC_588 3970-1144 52.9 µM -0.141011371709415 0.431536733917659 no 1921 0.443930479392565 2800 1888707
SGTC_961 1252-1571 372 µM -0.142088997582662 0.431063753506291 no 1922 0.443504854328738 2764 6813498
SGTC_2018 5133068 143 µM -0.142572429086418 0.43085160282438 no 1923 0.443313936698713 2658 785362
SGTC_2160 5660466 132.927 µM -0.142787181971781 0.430757366353803 no 1924 0.4432291303253 2618 2859134
SGTC_3001 9076041 71.4286 µM -0.143286078464552 0.430538459052598 no 1925 0.443032125078327 2675 16004211
SGTC_405 ebelactone b 50 µM -0.143312552658183 0.43052684322219 no 1926 0.443021671288734 2672 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3262 9137218 49.47 µM -0.143782671314562 0.430320583746453 no 1927 0.442836043483364 2620 17650664
SGTC_1743 st037606 46.3785 µM -0.145818914337005 0.429427424342737 no 1928 0.44203217201105 2696 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1053 3366-3204 134 µM -0.147186758000836 0.428827648140255 no 1929 0.441492306172892 2711 3632071 YPR165W RHO1
SGTC_1497 4476-2978 41.3 µM -0.148427872203619 0.428283582795815 no 1930 0.441002552425425 2750 1528379
SGTC_327 1273-0057 3.96 µM -0.149147830166045 0.427968038313209 no 1931 0.440718492461023 2732 3108138
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.149584955563238 0.427776476659319 no 1932 0.440546039173405 2659 5106787 A p450 inhibitor.
SGTC_1051 3253-3903 78 µM -0.149886815556224 0.427644202356304 no 1933 0.440426956932332 2650 5509239
SGTC_967 1306-0166 352 µM -0.150386992184069 0.427425044102001 no 1934 0.440229651646523 2732 4437607
SGTC_2849 9019321 12.99 µM -0.150886316357684 0.427206281696742 no 1935 0.440032697432188 2768 16489627
SGTC_3354 9151612 71.43 µM -0.150897020818415 0.427201592135429 no 1936 0.440028475310107 2795 27261949
SGTC_725 1497-0963 19 µM -0.151080827941406 0.427121068920975 no 1937 0.439955977989722 2763 3549977
SGTC_1969 st069479 40.1 µM -0.151615785365817 0.426886729182242 no 1938 0.4397449912127 2813 3895485
SGTC_1172 0370-0043 85 µM -0.151758547623512 0.426824196096122 no 1939 0.439688688783545 2820 376585
SGTC_1955 wogonin 32.4 µM -0.152241691650525 0.426612581776974 no 1940 0.439498156005902 2933 5281703 A flavanone.
SGTC_1453 4237-0541 195 µM -0.152412778757077 0.42653765166452 no 1941 0.439430689417131 2686 739892
SGTC_1781 st038725 66.3 µM -0.153159666248145 0.426210572398808 no 1942 0.439136181999899 2660 4270275 YIL048W NEO1
SGTC_812 4251-0442 148 µM -0.153967777335587 0.425856739073722 no 1943 0.438817571273108 2664 5723007
SGTC_3124 9127567 49.47 µM -0.154745245848945 0.425516379003861 no 1944 0.438511079282939 2843 17592030
SGTC_1479 0549-0158 134 µM -0.155407363884713 0.425226560797443 no 1945 0.438250089578328 2726 5440202
SGTC_797 k781-0471 270 µM -0.156054723516281 0.424943241608536 no 1946 0.437994943214671 2713 23738129
SGTC_560 2332-1943 155 µM -0.156265201309001 0.424851133615928 no 1947 0.437911992332807 2670 21177716
SGTC_3272 9137413 49.47 µM -0.15721039267433 0.424437555454623 no 1948 0.437539518990132 2679 17614870
SGTC_1790 st045711 43.5 µM -0.158584572071782 0.423836417682847 no 1949 0.436998092333368 2751 585119
SGTC_1438 4092-1045 4 µM -0.158652572419696 0.423806675372106 no 1950 0.436971303252815 2680 1351342
SGTC_1228 0124-0032 52.5 µM -0.158765351260125 0.423757348591469 no 1951 0.436926874096148 2754 X1228
SGTC_1708 st033234 31.827 µM -0.160921188198453 0.422814667378809 no 1952 0.43607773701069 2803 674664
SGTC_486 niguldipine 82 µM -0.162153884228335 0.422275845491732 no 1953 0.4355923370748 2674 1236 A calcium channel blocker.
SGTC_1189 1431-2119 7.28 µM -0.163316679337384 0.421767711160189 no 1954 0.435134551000427 2692 3107275
SGTC_1853 st056710 91.2 µM -0.164654463486875 0.421183268834109 no 1955 0.434607980269213 2881 269167
SGTC_82 0054-0107 293.755 µM -0.164768205820972 0.421133585823189 no 1956 0.434563215017037 2778 3104697
SGTC_230 MPP+ 141.667 µM -0.164937827862887 0.421059496712421 no 1957 0.434496458903204 2726 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1287 0971-0001 34.6 µM -0.165063539075984 0.421004589189916 no 1958 0.434446985452799 2685 4665869
SGTC_842 0271-0008 11.1 µM -0.1650749111387 0.420999622232322 no 1959 0.434442510046007 2810 1221709
SGTC_1722 st034304 3.6505 µM -0.165099650118725 0.420988817071123 no 1960 0.434432774198429 2736 4036148 YLR033W RSC58
SGTC_1462 k081-0014 26.5 µM -0.165472039270875 0.420826177107167 no 1961 0.434286227934791 2724 3270634
SGTC_2436 5633522 8.09 µM -0.166065357646659 0.420567074823039 no 1962 0.434052758080106 2773 5724242
SGTC_1559 coumarin 343 70.1 µM -0.166723732835618 0.420279602493771 no 1963 0.433793715398568 2834 108770 A hepatotoxic, DNA x-linker.
SGTC_1795 st049545 62.3 µM -0.166829248708713 0.420233534090643 no 1964 0.433752202023551 2686 5291882
SGTC_3064 1327-0027 10 µM -0.167834640996067 0.419794633068768 no 1965 0.433356684728443 2704 16000455 YPR107C YTH1
SGTC_2899 9053889 58.44 µM -0.168929293021518 0.419316879407239 no 1966 0.43292612890715 2719 6470052
SGTC_1902 st060212 70.5 µM -0.17018292014444 0.418769888235001 no 1967 0.432433141764745 2702 688944
SGTC_709 3807-1509 243 µM -0.17041776427643 0.418667436864212 no 1968 0.432340801305799 2685 1886677 YPL242C IQG1
SGTC_3258 9138477 49.47 µM -0.171315840127085 0.418275699852046 no 1969 0.431987712982576 2729 4970355
SGTC_2564 betulinic acid 100 µM -0.17176734908863 0.418078784082941 no 1970 0.431810217808498 2945 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_293 4049-0273 38.5 µM -0.171818432505939 0.418056506458653 no 1971 0.43179013699116 2728 1380311
SGTC_719 2810-4230 27.3 µM -0.172449692973149 0.417781233684934 no 1972 0.431542003978173 2697 721079
SGTC_2517 totarol 10 µM -0.173343831134338 0.417391397205593 no 1973 0.431190586436018 2781 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.173491168992641 0.417327166958917 no 1974 0.431132684376358 2708 3256 An antibiotic and ribosome inhibitor.
SGTC_1232 0279-0259 161 µM -0.175816973000332 0.416313552771315 no 1975 0.430218867411599 2729 1560000
SGTC_1219 1469-0211 33.1 µM -0.175967217283755 0.416248093508952 no 1976 0.430159848674177 2792 6822282
SGTC_1506 4226-2149 212 µM -0.176207817864541 0.416143272153333 no 1977 0.430065339560112 2808 991114
SGTC_3320 9137005 35.139 µM -0.176781379491915 0.415893415250086 no 1978 0.429840057848422 2769 4908713
SGTC_1029 k015-0030 64.7 µM -0.177178885203135 0.415720272372058 no 1979 0.429683940215757 2825 2208316
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.178067742321421 0.415333169175549 no 1980 0.429334887515335 2706 4620898
SGTC_920 mycophenolic acid 780.421 nM -0.17924713764029 0.41481966155765 no 1981 0.428871826274604 2763 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_824 1304-0008 100 µM -0.179478372253852 0.414718999257509 no 1982 0.428781049015491 2747 768245
SGTC_1772 st048439 82.2 µM -0.179627090868275 0.414654261225998 no 1983 0.428722667583093 2786 2927068 YDL195W SEC31
SGTC_587 k089-0003 57 µM -0.18052708266445 0.414262539363066 no 1984 0.428369397383007 2697 9659696
SGTC_657 3534-0529 86.7 µM -0.180573604421217 0.414242293060489 no 1985 0.428351137940496 2889 1049549
SGTC_3109 9122853 49.47 µM -0.180596378831823 0.414232381703417 no 1986 0.428342199210138 2783 1234709
SGTC_2471 5466956 24.79 µM -0.182867768540974 0.413244154909047 no 1987 0.427450886692351 2768 724419
SGTC_3241 9133421 49.47 µM -0.182947076444116 0.413209659846481 no 1988 0.427419772262656 2727 17018221
SGTC_326 k292-0812 17.5 µM -0.183292724953926 0.413059327461063 no 1989 0.427284171173977 2734 3579357
SGTC_739 1486-1183 203 µM -0.186415239047375 0.411701837444756 no 1990 0.426059571426792 2798 4346692
SGTC_984 1492-0255 2.91 µM -0.186534786972904 0.411649885753651 no 1991 0.426012700745743 2865 1585198
SGTC_400 oxethazaine 37.5 µM -0.187793068991053 0.411103170888782 no 1992 0.425519434625 2810 4621 A local anesthetic.
SGTC_463 ikarugamyin 104 µM -0.188010586785205 0.411008678375935 no 1993 0.425434176060385 2723 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2947 9072639 7.68 µM -0.190224022842187 0.410047427956534 no 1994 0.424566793646672 2814 16488146
SGTC_1464 k208-0027 110 µM -0.191591197419227 0.409453961291328 no 1995 0.424031219110178 2946 X1464
SGTC_3191 9110352 49.47 µM -0.192372009416665 0.409115117380351 no 1996 0.423725408076299 2696 17122424
SGTC_2432 5630864 12.22 µM -0.192480982442455 0.40906783245797 no 1997 0.423682731599664 2891 5714970
SGTC_1564 D-Arginine 115 µM -0.193527558547555 0.408613775900223 no 1998 0.423272912696983 2775 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2502 avocadyne acetate 18.59 µM -0.194168649926312 0.408335699234323 no 1999 0.423021914712317 2696 3952079
SGTC_931 2812-0076 566 µM -0.194505298259512 0.40818969476917 no 2000 0.422890123770056 2717 3450959
SGTC_1546 5-methoxyflavanone 78.7 µM -0.196513045662529 0.407319199574995 no 2001 0.422104311387669 2838 147795
SGTC_3171 9103192 49.47 µM -0.197440943792232 0.406917046882112 no 2002 0.421741245830282 2780 13018434
SGTC_1719 st032227 49.2 µM -0.199446593187074 0.406048130682942 no 2003 0.420956708217321 2788 3125804
SGTC_1857 st056007 79.3 µM -0.200132456651654 0.405751097001156 no 2004 0.42068849504122 2836 619834
SGTC_3056 9094900 49.47 µM -0.200236885315722 0.405705875800809 no 2005 0.420647660484028 2788 25236784
SGTC_495 decylubiquinone 155 µM -0.200974923446215 0.405386315833176 no 2006 0.420359091095696 2826 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_471 1-acyl-paf 4 µM -0.200986029003917 0.405381507766384 no 2007 0.42035474920209 2756 16759367
SGTC_2083 5306046 65.942 µM -0.201123227949046 0.405322109703975 no 2008 0.420301109901953 2794 539837
SGTC_2157 5649910 96.377 µM -0.201555612319204 0.405134930160764 no 2009 0.420132074593871 2781 2858091
SGTC_22 0964-0034 14.468 µM -0.202351725581404 0.404790348871379 no 2010 0.419820882538122 2793 138402
SGTC_510 ag-490 170 µM -0.202852605873714 0.404573590928807 no 2011 0.419625119532421 2824 5328779
SGTC_2398 5228213 48.84 µM -0.202874138023589 0.404564273461155 no 2012 0.419616704397557 2915 80771 YMR134W ERG29
SGTC_431 k089-0097 107 µM -0.204452938186006 0.403881237299737 no 2013 0.418999782522318 2870 5499420
SGTC_3098 9119039 49.47 µM -0.204688342182734 0.403779419540288 no 2014 0.418907814579904 2755 17161528
SGTC_2184 6075246 200 µM -0.207266739013044 0.402664630557064 no 2015 0.417900774262458 2837 2267320
SGTC_2832 7992762 51.95 µM -0.207401815521941 0.402606250952346 no 2016 0.417848032422625 2759 2985177
SGTC_1037 k284-1091 78.7 µM -0.208211998586621 0.402256138226642 no 2017 0.417531720186982 2763 3334711
SGTC_1524 corynanthine 62.1 µM -0.209177356933551 0.401839070395441 no 2018 0.417154893987518 2969 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_683 panaxydol 45 µM -0.209825005947208 0.401559326478155 no 2019 0.416902127779736 2825 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2229 7354935 190 µM -0.210315900565667 0.401347324265243 no 2020 0.416710562978711 2848 318112
SGTC_3188 9110789 49.47 µM -0.214549246441713 0.399520284290335 no 2021 0.415059383905944 2951 849217
SGTC_1175 0741-0056 27.6 µM -0.215775417262065 0.398991498636028 no 2022 0.414581405559681 2987 765927
SGTC_2439 5492030 7.2 µM -0.216591771857121 0.398639548756525 no 2023 0.414263249320473 2910 5722370
SGTC_301 4119-0100 24.5 µM -0.21776971789896 0.398131853527594 no 2024 0.413804269964936 2813 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_426 0988-0037 14.6 µM -0.222663666516038 0.396024414994265 no 2025 0.411898640680097 2858 5383008
SGTC_213 1246-0773 967 nM -0.222794381567218 0.3959681676567 no 2026 0.411847770488294 2829 6251622
SGTC_134 0269-0018 6.916 µM -0.223119801658534 0.395828147181396 no 2027 0.411721133647796 2878 4378915
SGTC_2177 5811945 192 µM -0.22393968444249 0.395475430879011 no 2028 0.411402118032992 2961 5343475
SGTC_2052 5265182 7.135 µM -0.223990369631904 0.395453628748418 no 2029 0.411382398393928 2951 1239884
SGTC_2356 9061756 188.97 µM -0.225206428759107 0.394930641648534 no 2030 0.410909344239413 2887 20104043
SGTC_1565 sinapyl alcohol 95.1 µM -0.225481097496291 0.394812541810836 no 2031 0.410802514394148 2879 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2477 5967686 25.23 µM -0.225731725608995 0.394704787198677 no 2032 0.410705040698284 2791 776118
SGTC_776 4476-4378 112 µM -0.226832474104631 0.394231628795871 no 2033 0.410277005555081 2907 2892008
SGTC_1431 4049-0260 9.09 µM -0.226943433377226 0.394183941431208 no 2034 0.410233864046276 2775 3854841
SGTC_1804 st050076 49.1 µM -0.229586498782204 0.393048492155701 no 2035 0.409206549536501 2928 3895976
SGTC_2298 7976326 193.81 µM -0.229859738326862 0.392931161346748 no 2036 0.409100381406283 2819 2235818
SGTC_3299 9121982 43.1275 µM -0.229954118668019 0.39289063608396 no 2037 0.409063711161053 2839 17594604 YPL160W CDC60
SGTC_1362 1611-0397 101 µM -0.231606981850212 0.392181114195294 no 2038 0.408421642110786 2831 27816
SGTC_276 colchicine 750 µM -0.232625859272942 0.391743920705212 no 2039 0.408025972659469 2926 2833 A microtubule depolymerizer.
SGTC_2913 7966556 36.57 µM -0.233217324567893 0.391490189565504 no 2040 0.407796326835158 2903 2976516
SGTC_939 1165-0479 45.3 µM -0.235479780766417 0.390520051305442 no 2041 0.406918185145131 2908 1377347
SGTC_702 1488-0190 94 µM -0.236325937712586 0.390157395009992 no 2042 0.406589880748316 2902 949357
SGTC_1338 1486-1223 76 µM -0.23642986644229 0.390112858547602 no 2043 0.406549561475713 2896 3444526
SGTC_1901 st060216 58.6 µM -0.237361956493394 0.389713495578766 no 2044 0.406188000382125 2823 688792
SGTC_2183 6420625 130.508 µM -0.237729507610662 0.389556046739541 no 2045 0.406045447949872 2814 2897619
SGTC_1196 1588-0294 184 µM -0.238415831128242 0.389262093070567 no 2046 0.405779294967048 2882 6144269
SGTC_2808 7946468 45.46 µM -0.240185418555133 0.388504468079168 no 2047 0.405093258589023 2914 2970879
SGTC_299 1273-0059 1.44 µM -0.241667049300063 0.387870453812119 no 2048 0.404519081842104 2936 2848077
SGTC_2748 diazoxide 86.69 µM -0.241731923027411 0.387842700088686 no 2049 0.404493945998233 2912 3019 A potassium channel activatior.
SGTC_1066 ketoconazole 628 nM -0.242354812424224 0.38757625005232 no 2050 0.404252622602379 2994 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1466 k213-0079 57.5 µM -0.244209904452497 0.386783021414269 no 2051 0.403534128308577 2831 3657981
SGTC_630 4356-0227 183 µM -0.245039813801973 0.386428308918731 no 2052 0.403212801964056 2854 779312
SGTC_1324 1418-0026 34.4 µM -0.245168754713589 0.386373206646317 no 2053 0.403162884163635 2945 1372513
SGTC_2529 gangaleoidin 93.61 µM -0.246738932897032 0.385702382784091 no 2054 0.402555136901551 2831 4565183
SGTC_1475 4092-1048 11.7 µM -0.247229248143833 0.385492976369024 no 2055 0.402365405493164 2922 2881759
SGTC_109 0132-0036 33.701 µM -0.247746820668386 0.385271964983061 no 2056 0.402165151615052 2798 67274 A color developer.
SGTC_2508 celastrol 40.54 µM -0.248028845469102 0.385151551755803 no 2057 0.402056044262029 2856 122724 Celastrol is a natural product and antioxidant.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.248170518283533 0.385091067349585 no 2058 0.402001237969461 2998 5393153
SGTC_1456 k015-0012 13 µM -0.248336408037301 0.385020247553406 no 2059 0.401937065775017 2967 2989616
SGTC_2825 7998094 58.44 µM -0.249351217044798 0.384587100229901 no 2060 0.401544558328587 2907 2987815
SGTC_1511 0906-3109 28.5 µM -0.249748992146542 0.384417358560935 no 2061 0.401390734095371 2829 2882180
SGTC_1697 st025554 27.742 µM -0.250104714510007 0.384265580730415 no 2062 0.401253185084742 2814 1269519
SGTC_1899 st063254 59.6 µM -0.250199775153109 0.384225023736443 no 2063 0.401216429564317 2809 3093813
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.254286091608707 0.382482827763598 no 2064 0.399637272014151 2864 641818 YHR062C RPP1
SGTC_1777 st045864 34.765 µM -0.254624848722894 0.382338505253354 no 2065 0.399506432558475 2861 4691462
SGTC_3112 9123419 49.47 µM -0.25466451174514 0.382321608471685 no 2066 0.399491114095455 2838 17015854
SGTC_2188 6126565 140.678 µM -0.254681635004209 0.382314313888293 no 2067 0.399484500879935 2963 874518
SGTC_2335 9018011 154.17 µM -0.255694336823716 0.38188297283757 no 2068 0.399093434201005 2961 6458208
SGTC_1518 st038567 90.8 µM -0.25620361275044 0.381666111820049 no 2069 0.398896809570293 2827 77966
SGTC_2446 5162541 200 µM -0.257150826242357 0.381262866060753 no 2070 0.398531171362066 2827 1549321
SGTC_3113 9123498 49.47 µM -0.258700243836893 0.380603529227048 no 2071 0.397933265705568 2832 8897275
SGTC_1401 3807-4679 7.6 µM -0.258857988887451 0.380536422046347 no 2072 0.397872406793034 2851 3291456
SGTC_685 1278-0033 54.9 µM -0.259874674024708 0.380103994814122 no 2073 0.39748022373003 3009 3590572
SGTC_800 3448-7362 155 µM -0.260501612793887 0.379837413262065 no 2074 0.397238435709131 2943 15991913
SGTC_3091 9116372 49.47 µM -0.260592850906421 0.379798622526605 no 2075 0.397203251698117 3025 17169793
SGTC_3330 9141424 71.43 µM -0.26089960067351 0.379668213869997 no 2076 0.397084966399607 3010 27261020
SGTC_92 0063-0024 660.874 µM -0.26198584129908 0.379206530069267 no 2077 0.396666179030309 2812 3594437
SGTC_2780 5215298 71.43 µM -0.262006256997315 0.379197854451786 no 2078 0.396658309136037 3011 2834131
SGTC_2827 7993847 71.43 µM -0.262546999290045 0.378968089061201 no 2079 0.396449877781453 2974 2985692
SGTC_1492 4158-0558 28.5 µM -0.262738976035723 0.378886527006259 no 2080 0.396375886664538 2977 3967268
SGTC_503 tyrphostin 8 294 µM -0.26307970105315 0.378741781960398 no 2081 0.396244574614282 2988 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3089 9117425 49.47 µM -0.264291422830753 0.378227162472477 no 2082 0.395777684487268 2931 9401657
SGTC_569 4130-2812 160 µM -0.264354815906229 0.378200245304596 no 2083 0.395753262526798 2869 743552
SGTC_2612 dictamnine 15.46 µM -0.264563026762093 0.378111841597903 no 2084 0.39567305290334 2966 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_558 k064-0027 21.3 µM -0.266767272299704 0.377176338928611 no 2085 0.394824177123323 2979 5088526
SGTC_910 3454-3003 490 µM -0.267418493874379 0.376900091938838 no 2086 0.394573480862258 2983 820824
SGTC_2512 diallyl trisulfide 49.23 µM -0.267767290327433 0.376752159028478 no 2087 0.394439225052633 2888 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_264 promethazine 12.5 mM -0.268184232347801 0.37657534769861 no 2088 0.394278755675452 2913 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.269865313387604 0.375862719777348 no 2089 0.393631936654606 2970 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_546 peri-Naphthalide 147 µM -0.27226099221707 0.374847898061904 no 2090 0.39271067367308 2952 223824 A penicillin ester.
SGTC_1959 st077091 55.8 µM -0.273250373171732 0.37442904352711 no 2091 0.39233038027803 2845 821356 YKL052C ASK1
SGTC_1877 wortmannin 25 µM -0.273852741871965 0.374174103194513 no 2092 0.392098895077661 3027 312145 A covalent inhibitor of PI 3-kinase.
SGTC_957 1187-1561 14.1 µM -0.274309016855973 0.373981030676815 no 2093 0.391923577868405 2861 1538454
SGTC_944 3370-0224 231 µM -0.275059928446543 0.373663351675279 no 2094 0.391635098494862 2930 4580514
SGTC_2269 7935389 174.42 µM -0.275589353840144 0.373439425704896 no 2095 0.391431743766912 2867 97605
SGTC_747 3448-8087 38.7 µM -0.276343608447857 0.373120479698459 no 2096 0.391142082358818 2942 5168703
SGTC_1711 st032263 62.8 µM -0.276770141564657 0.372940153293491 no 2097 0.390978304724579 2938 3958979
SGTC_3269 9137823 49.47 µM -0.277456066948716 0.372650221401679 no 2098 0.390714967755155 2868 17682936
SGTC_2766 oltipraz 83.91 µM -0.277680172278549 0.372555510570576 no 2099 0.390628941237104 3043 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3198 9112019 49.47 µM -0.277758784439331 0.372522289522131 no 2100 0.390598765933842 2876 45595555
SGTC_1050 3232-1156 69.3 µM -0.278677869975112 0.372133959666139 no 2101 0.390246023582204 2930 700529
SGTC_1361 1608-0041 5.61 µM -0.278754251885701 0.372101692807026 no 2102 0.390216712489323 2913 X1361
SGTC_177 1327-0068 8.361 µM -0.27909011750862 0.371959820020061 no 2103 0.39008783351015 2951 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.279758042011942 0.371677734123415 no 2104 0.389831572194105 2905 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2074 5212007 75.395 µM -0.280678156366912 0.371289253216948 no 2105 0.389478632111828 2981 758611
SGTC_583 1488-1091 88.9 µM -0.284723599163758 0.36958278944579 no 2106 0.387927954571106 2986 4303273
SGTC_1065 prochlorperazine maleate 2.48 µM -0.284878018078089 0.369517702510678 no 2107 0.387868798758896 2928 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2649 anisomycin 9.56 µM -0.285254826773175 0.369358894898335 no 2108 0.387724459333413 2971 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1327 1436-0082 2.18 µM -0.286464848247497 0.368849077084961 no 2109 0.387261056431949 2938 15992205
SGTC_137 0438-0332 85.389 µM -0.288848692675011 0.3678453686186 no 2110 0.386348584057929 2974 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_851 0394-0702 453 µM -0.289732140605979 0.367473624933571 no 2111 0.386010582900614 3045 762646
SGTC_348 k064-0012 10.7 µM -0.290906169957066 0.366979800444752 no 2112 0.385561541176921 2874 5066323
SGTC_2001 4023502 57.655 µM -0.291293713420947 0.366816838766187 no 2113 0.385413347524556 3042 108941 YCR052W RSC6
SGTC_1988 st071872 53.4 µM -0.29266919980602 0.366238641912829 no 2114 0.384887507257757 3050 16414116
SGTC_2593 nobiletin 86.24 µM -0.293100025716484 0.366057603115873 no 2115 0.384722848557228 3001 72344 An anti-infammatory.
SGTC_2618 avocadyne 43.43 µM -0.293254386548987 0.36599274588703 no 2116 0.384663857966105 2888 3015189
SGTC_2304 7443016 91.4 µM -0.297674483248622 0.364137201248689 no 2117 0.382975810220204 2862 939854
SGTC_1337 1486-1011 40.3 µM -0.298127268069918 0.363947302265837 no 2118 0.382803015206926 2936 X1337
SGTC_2105 5350118 200 µM -0.298320651967347 0.363866206798282 no 2119 0.382729221753603 2955 2133313
SGTC_1407 3909-7909 12.3 µM -0.299409611185055 0.363409666073614 no 2120 0.382313764839967 2951 4411780
SGTC_248 streptozotocin 5.23457 mM -0.299525418356601 0.363361125892162 no 2121 0.382269590345965 3033 5300 DNA alkylating agent.
SGTC_694 1315-0438 43.2 µM -0.299867789164777 0.363217635167901 no 2122 0.382139002412521 2966 6793154
SGTC_2697 mebhydrolin 72.4 µM -0.30024278622845 0.363060492508412 no 2123 0.381995985474727 3100 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_663 1486-0733 13.9 µM -0.300815984205558 0.362820338235876 no 2124 0.38177740949979 2931 722445 YPR165W RHO1
SGTC_509 pifithrin 175 µM -0.300905263373429 0.362782937559909 no 2125 0.381743368315741 3019 4817 A p53 inhibitor.
SGTC_1359 1582-0056 520 nM -0.301602025876645 0.362491096003086 no 2126 0.381477731723406 3040 3661189
SGTC_699 0375-0592 111 µM -0.301933044371724 0.362352475659955 no 2127 0.381351552426067 3071 762578
SGTC_2453 5731132 22.18 µM -0.305417343852255 0.360894456318781 no 2128 0.380024156981399 3096 1362040
SGTC_1480 1070-0044 41.2 µM -0.305771398623036 0.360746413320493 no 2129 0.379889353351914 3016 3124987
SGTC_3331 9141060 1.957 µM -0.306169007749458 0.36058018355761 no 2130 0.379737984133628 2949 4906567 YPR165W RHO1
SGTC_1999 st074831 12.5 µM -0.306737165901193 0.36034269752125 no 2131 0.379521719130179 2971 17112523
SGTC_616 4092-0450 108 µM -0.307919617029867 0.359848614245055 no 2132 0.379071749165835 2998 787165
SGTC_1754 st042065 16.137 µM -0.308225981603468 0.359720638977711 no 2133 0.378955191883248 2993 1126236 YIL048W NEO1
SGTC_754 3474-0146 171 µM -0.308785868351189 0.359486802526624 no 2134 0.378742209803577 2929 24762078
SGTC_3133 9127736 49.47 µM -0.309940657986352 0.35900467138262 no 2135 0.37830304178304 3126 27243420
SGTC_660 4031-1742 102 µM -0.310244048187992 0.358878041481015 no 2136 0.378187688136055 2952 6738706
SGTC_2663 amphotericin b 100 µM -0.310421589313509 0.358803946031651 no 2137 0.378120189289372 2977 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_655 k060-0012 42 µM -0.31058803614265 0.358734485528526 no 2138 0.378056911729601 2955 5994525
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.310792538861792 0.358649150186464 no 2139 0.377979171062251 3059 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2041 5107442 45.335 µM -0.311571363867563 0.358324225024892 no 2140 0.377683149966385 3118 793005
SGTC_2164 5685496 200 µM -0.311671669259574 0.358282385146754 no 2141 0.377645030429342 3068 759046
SGTC_528 3492-0019 172 µM -0.313581642053608 0.357486013105922 no 2142 0.37691940213408 3031 2869262
SGTC_554 4483-2211 187 µM -0.313656559502869 0.357454788544906 no 2143 0.376890948672454 3050 747107
SGTC_1948 st076329 66.6 µM -0.314354398374451 0.357163984781167 no 2144 0.376625943336565 2894 24208413
SGTC_658 3253-0951 102 µM -0.315578077902753 0.356654252779324 no 2145 0.376161389640855 3007 1184878
SGTC_482 fipronil 114 µM -0.315644695290335 0.356626510191655 no 2146 0.37613610437595 2994 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_357 1325-0123 420 µM -0.316180241261391 0.356403511437322 no 2147 0.375932852120476 3085 1098503
SGTC_829 1635-0120 117 µM -0.316980597784044 0.356070338367351 no 2148 0.375629162211826 3095 285054
SGTC_678 1218-2179 85.9 µM -0.317098064826136 0.356021448330776 no 2149 0.375584596610137 3019 6820081 YOR116C RPO31
SGTC_1 0258-0098 57.368 µM -0.318829270056212 0.355301191898826 no 2150 0.374927990692643 3018 6790032 YDR047W HEM12
SGTC_772 k072-0172 35.3 µM -0.319625976420628 0.354969900914384 no 2151 0.374625940111629 2974 5861980
SGTC_3036 9090181 49.47 µM -0.319922061848452 0.354846808909454 no 2152 0.37451370658362 2940 25236586
SGTC_2602 kawain 100 µM -0.320994899043782 0.354400923810625 no 2153 0.37410712825224 2999 5369129
SGTC_99 0109-0120 622.8 µM -0.321766050802082 0.354080546292884 no 2154 0.373814967571621 3200 759414
SGTC_496 calpeptin 138 µM -0.322334416645358 0.353844482937297 no 2155 0.373599681312598 3028 73364 A calpain inhibitor.
SGTC_2819 7996655 46.38 µM -0.322438220945257 0.353801375236902 no 2156 0.373560366459384 3027 6456960
SGTC_2303 7774051 200 µM -0.323076794859325 0.353536230430174 no 2157 0.373318541857458 3163 2953184
SGTC_1245 0418-0076 17.2 µM -0.324229021599422 0.35305798963175 no 2158 0.372882325889676 3155 6790114
SGTC_1928 4'-methoxychalcone 40.3 µM -0.324679178644364 0.352871211385123 no 2159 0.372711947337606 3183 641818
SGTC_3006 9075424 71.4286 µM -0.325154016512389 0.352674231042023 no 2160 0.372532254402875 3009 7465181
SGTC_3220 9131269 49.47 µM -0.325267527693252 0.352627148244966 no 2161 0.372489302464214 2985 17722206
SGTC_2888 9058547 12.99 µM -0.325555817985515 0.352507579747844 no 2162 0.372380222305061 2971 16476514
SGTC_3081 9117243 49.47 µM -0.32622878213904 0.352228524364332 no 2163 0.372125633269758 3151 45595589
SGTC_2760 etidronate 98.04 µM -0.326263209172452 0.352214250780024 no 2164 0.37211261068222 2998 3305 A chelator and antioxidant.
SGTC_2561 acetosyringone 100 µM -0.328576513969992 0.35125562333648 no 2165 0.371237901197077 2947 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2597 laccaic acid a 100 µM -0.329138055545128 0.351023064373742 no 2166 0.371025670534837 3112 5491415 A textile dye.
SGTC_342 k048-0088 23.3 µM -0.330407047982156 0.350497724624482 no 2167 0.370546208388606 2955 6820570
SGTC_3169 9102970 49.47 µM -0.331289279148072 0.350132665354113 no 2168 0.37021299426446 3017 17027839
SGTC_3345 9148410 3.559 µM -0.332000416338781 0.349838503976354 no 2169 0.369944472314399 3122 4903596
SGTC_2486 5283202 22.39 µM -0.332304359227829 0.349712805699779 no 2170 0.369829724284771 3024 1377751
SGTC_156 3474-0145 5.642 µM -0.334432667938767 0.3488330869681 no 2171 0.36902654582788 3045 2265471
SGTC_119 0121-0043 24.815 µM -0.334644285153081 0.348745661058018 no 2172 0.368946717173395 3014 1092378
SGTC_2865 9030313 51.95 µM -0.33478964623928 0.348685612348305 no 2173 0.368891885684764 2966 42562754
SGTC_441 propafenone 146 µM -0.334954774932669 0.348617402232945 no 2174 0.368829600917052 2964 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1636 st007707 68.9 µM -0.335957506599426 0.348203306553675 no 2175 0.368451455342272 3204 403051
SGTC_3155 9099265 49.47 µM -0.337037303431557 0.347757587751587 no 2176 0.36804438974059 3106 25236499
SGTC_3341 9147222 25.867 µM -0.340248125745357 0.346433468344364 no 2177 0.366834839341831 3129 1939759
SGTC_1983 st071813 46.9 µM -0.340622690609015 0.346279122343765 no 2178 0.36669382264273 3067 11838595
SGTC_2241 6772625 37.8075 µM -0.340927665240056 0.346153471066702 no 2179 0.366579018657405 2985 2285411
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.340958521968552 0.346140758862775 no 2180 0.366567403682561 3010 6708784 An antioxidant flavonoid
SGTC_612 0302-0167 22.4 µM -0.341391511570159 0.345962396217367 no 2181 0.36640443224157 3074 235821
SGTC_624 k048-0052 28 µM -0.341659188888449 0.345852148224235 no 2182 0.366303694159615 3053 6835531
SGTC_69 0096-0274 206.684 µM -0.341925891804792 0.345742314554002 no 2183 0.366203331947816 3284 6741392
SGTC_1387 3342-1166 1.8 µM -0.342071896881596 0.345682192200121 no 2184 0.366148393070931 3050 3418228
SGTC_2750 bromebric acid 70.15 µM -0.343359368586555 0.345152202340451 no 2185 0.365664061343623 3171 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.344099341835367 0.344847728432453 no 2186 0.365385788927737 3081 5379071
SGTC_811 0416-0114 265 µM -0.344532235113987 0.344669654080347 no 2187 0.365223029044337 3107 6612453
SGTC_1404 3909-7820 48.3 µM -0.344851034718015 0.344538535137213 no 2188 0.36510318179541 3117 23741373
SGTC_2130 NSC 7 2.4545 µM -0.346277100835836 0.343952237885123 no 2189 0.364567238107575 3117 21448
SGTC_998 3996-0085 177 µM -0.346457561013293 0.343878072159355 no 2190 0.364499436464313 3063 715391
SGTC_2843 9000894 45.46 µM -0.347676326448692 0.343377339982203 no 2191 0.364041638771481 3085 2242070
SGTC_590 k048-0076 22.4 µM -0.348043325854655 0.343226611345425 no 2192 0.363903822909323 3132 6832814
SGTC_397 arbidol 50 µM -0.348112241566028 0.343198310071063 no 2193 0.363877945597887 3159 131410 A RNA synthesis inhibitor.
SGTC_122 0236-0016 402.397 µM -0.348816309407201 0.342909224424285 no 2194 0.363613609209674 3065 6808838
SGTC_2173 5763948 167 µM -0.34973762270924 0.342531078104472 no 2195 0.363267807889639 3019 2867177
SGTC_180 1486-1293 102.781 µM -0.350198351330786 0.342342034557476 no 2196 0.363094921986189 3177 4140536
SGTC_1645 Cervolide 78 µM -0.351305156434107 0.341888058065916 no 2197 0.362679713452688 3064 23173 A fragrance.
SGTC_555 4296-0685 37 µM -0.351308590723779 0.341886649784088 no 2198 0.362678425359057 3077 2908540 YHR072W ERG7
SGTC_354 2783-3500 4.88 µM -0.352372011777527 0.341450683979274 no 2199 0.362279644505773 3038 6740761
SGTC_272 doxorubicin 8.13 µM -0.352486463916268 0.341403775160731 no 2200 0.362236734071658 3037 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_825 1988-2224 89.6 µM -0.353992469795406 0.340786759094621 no 2201 0.361672263282544 3024 1180859
SGTC_1661 st013063 9.66 µM -0.354483220684245 0.340585788559365 no 2202 0.361488388338086 3033 721395
SGTC_2051 5263410 176 µM -0.355392095100563 0.340213709123992 no 2203 0.361147935027855 3127 227584
SGTC_793 0488-0545 106 µM -0.356256278584588 0.33986006971325 no 2204 0.360824324368137 3010 292548
SGTC_2143 5623677 140.463 µM -0.357855832390059 0.339205875452586 no 2205 0.360225602682697 3091 5375313
SGTC_2993 9054257 71.4286 µM -0.360402658075405 0.338165261039982 no 2206 0.359273019573037 2999 6470217 YGL055W OLE1
SGTC_1625 st003711 30.1 µM -0.360478793154972 0.338134171776672 no 2207 0.35924455637848 3247 24207034 YER133W GLC7
SGTC_2742 clothiapine 36.27 µM -0.361265313909316 0.337813065787606 no 2208 0.358950560356888 3101 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.361582040214562 0.337683792007869 no 2209 0.358832193834005 3010 91467 include heat shock
SGTC_2735 sertaconazole 140 nM -0.361647239570734 0.337657182867805 no 2210 0.358807829301549 3079 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_37 0566-0070 1.56 µM -0.362009472367275 0.337509363318897 no 2211 0.358672475964332 3117 1626686
SGTC_904 1141-0088 396 µM -0.362019703829712 0.337505188439264 no 2212 0.358668653093332 3076 1378119
SGTC_1756 st041558 35.5 µM -0.362428124352332 0.337338551523395 no 2213 0.358516062921029 3227 3955792
SGTC_1786 berberine 21.6 µM -0.362778927331365 0.337195448220305 no 2214 0.358385017294531 3037 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_210 3551-0445 56.827 µM -0.365114185301049 0.336243425919718 no 2215 0.357513086230946 3174 2865180 YOR207C RET1
SGTC_2499 avocadenofuran 51.48 µM -0.365287217507175 0.336172926988941 no 2216 0.357448509546141 3009 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_206 4546-0025 72.014 µM -0.365411398283691 0.336122335265452 no 2217 0.357402167031298 3132 6620745 YIL048W NEO1
SGTC_370 0180-0345 38.7 µM -0.366686150295331 0.33560316818801 no 2218 0.356926569252933 2952 3989527
SGTC_381 3461-2219 42.7 µM -0.367424162167424 0.335302742073415 no 2219 0.35665132562792 3152 2883159
SGTC_1633 st005664 67.9 µM -0.367777637107433 0.335158888577603 no 2220 0.35651952256732 3002 2063822
SGTC_274 sirtinol 40.1 µM -0.368125382277899 0.335017390510996 no 2221 0.356389872731136 3087 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_3217 9129673 49.47 µM -0.368521775974685 0.334856125837321 no 2222 0.356242105505945 3227 17248312
SGTC_954 1189-0853 2.85 µM -0.369475600058014 0.334468206833909 no 2223 0.355886628461849 3065 2828194
SGTC_1269 0831-0796 3.05 µM -0.369887236316997 0.334300849456037 no 2224 0.355733255996343 3174 927758
SGTC_2374 9071832 200 µM -0.370237808472713 0.334158344640898 no 2225 0.355602653951043 3091 17381698
SGTC_604 1000-0114 314 µM -0.371159610797639 0.333783753371141 no 2226 0.355259326907698 3195 1572745
SGTC_1676 st018489 23.4 µM -0.372264038623393 0.333335166952372 no 2227 0.354848135319269 3056 3696235
SGTC_1866 st057638 64 µM -0.374478463366817 0.332436450431039 no 2228 0.35402418833805 3069 688802
SGTC_1284 0929-0043 16 µM -0.37468774408925 0.332351564282847 no 2229 0.353946354074895 3112 1239883
SGTC_2489 cantharidin 73.42 µM -0.375353650197154 0.332081523986881 no 2230 0.353698735422499 3048 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_584 0986-0246 15.4 µM -0.375447136089257 0.332043620275637 no 2231 0.353663977439327 3170 53315 YDR232W HEM1
SGTC_928 2764-0428 58.7 µM -0.379026560118244 0.330593644007861 no 2232 0.352334070338424 3174 662578
SGTC_751 0833-0568 350 µM -0.379852681431204 0.330259353247058 no 2233 0.35202738696444 3163 6954252
SGTC_696 1560-0013 611 µM -0.380177626983078 0.330127900824261 no 2234 0.351906782857262 3267 1650269
SGTC_777 1315-0167 517 µM -0.38371448941895 0.328698468995633 no 2235 0.350595036111815 3142 4221767
SGTC_2284 7945075 39.21 µM -0.384140796713826 0.328526344433799 no 2236 0.350437047701409 3214 1245402
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.384210442902645 0.328498227752675 no 2237 0.350411239456967 3209 688664
SGTC_1530 rhein 70.4 µM -0.384793593012333 0.328262843863698 no 2238 0.350195173182891 3074 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_282 k297-0036 65.7 µM -0.384795327884608 0.328262143698 no 2239 0.350194530457762 3200 5061378
SGTC_253 dyclonine 31.25 µM -0.386271011396073 0.327666801005978 no 2240 0.349647983605115 3125 3180 An oral anasthetic.
SGTC_1422 4031-0024 15.5 µM -0.386311242265263 0.32765057658105 no 2241 0.349633087710576 3141 782427
SGTC_1813 st051246 8.6015 µM -0.386464317962868 0.327588846731965 no 2242 0.349576411970062 3171 5291959
SGTC_2496 diffractaic acid 79.83 µM -0.387624567206337 0.327121113834126 no 2243 0.349146942848501 3315 94870 An apoptosis inducer which activates caspases.
SGTC_3335 9143315 29.6265 µM -0.388099235511322 0.326929838319345 no 2244 0.348971298836719 3102 4899691
SGTC_1594 piperine 70.1 µM -0.388549589009238 0.326748402888719 no 2245 0.348804682070815 3078 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2220 6782180 200 µM -0.389152326386971 0.32650564015075 no 2246 0.348581733639278 3140 833803
SGTC_1640 st009078 66.4 µM -0.389491136732623 0.326369210762041 no 2247 0.348456432963411 3194 690618
SGTC_1825 st052143 62.6 µM -0.390217760309831 0.326076698240427 no 2248 0.348187764868315 3249 674173
SGTC_1382 3002-2117 298 µM -0.390606053962572 0.325920429028369 no 2249 0.34804422502891 3248 1497314
SGTC_454 lyso-paf C-16 6.67 µM -0.390990864743119 0.325765591664725 no 2250 0.347901994173758 3140 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_72 0744-0168 198.391 µM -0.391975787906125 0.325369422382301 no 2251 0.347538051827313 3012 677577
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.39223187003922 0.325266449812266 no 2252 0.347443449035862 3122 65057 A dermal irritant. YDR527W RBA50
SGTC_3233 9132340 49.47 µM -0.392503418917125 0.325157272519918 no 2253 0.347343142843419 3092 17682950
SGTC_1043 0916-0009 19.3 µM -0.394143213569354 0.324498305883945 no 2254 0.346737654048415 3279 3101130
SGTC_2274 7947094 46.08 µM -0.395015838781136 0.324147857093562 no 2255 0.346415599449907 3086 2971028
SGTC_628 1636-0253 16 µM -0.395046301632784 0.324135625936737 no 2256 0.34640435871016 3160 4456143
SGTC_2231 micatex 6.853 µM -0.395409756966838 0.323989709425161 no 2257 0.346270254755991 3149 20737 An antifungal of unknown mechanism.
SGTC_1997 st073024 93.8 µM -0.39553720811036 0.323938547982303 no 2258 0.346223233726782 3212 686268
SGTC_1846 st056244 14.8 µM -0.395602445238828 0.323912361778491 no 2259 0.346199166465001 3138 5393182
SGTC_58 0957-0393 9 µM -0.398516441249451 0.32274357332165 no 2260 0.345124770719036 3233 6997992
SGTC_2759 disulfiram 3.38 µM -0.399228441936895 0.322458259027301 no 2261 0.344862444008519 3055 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_304 1310-0298 97 µM -0.399414818733988 0.322383591012781 no 2262 0.344793788388152 3166 1550234
SGTC_2046 4110841 106 µM -0.399841993632317 0.322212479247201 no 2263 0.344636449255515 3266 44119630 YMR134W ERG29
SGTC_637 1181-0519 7.26 µM -0.399890149585422 0.322193191968942 no 2264 0.344618713905988 3153 6252091 YGR060W ERG25
SGTC_761 k216-0224 480 µM -0.402104380744529 0.321306872554154 no 2265 0.343803604448613 3285 1340404
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.40304314336258 0.320931408283903 no 2266 0.343458243097509 3133 165521
SGTC_1395 3486-0190 4.35 µM -0.403584761878333 0.320714867646755 no 2267 0.343259046494364 3285 6748079
SGTC_3277 9138724 49.47 µM -0.403603248704445 0.320707477636635 no 2268 0.343252248172598 3128 15943418
SGTC_287 k060-0039 29.6 µM -0.404145825633003 0.320490617060238 no 2269 0.343052744226755 3245 5861974
SGTC_3100 9120536 49.47 µM -0.404445486620838 0.320370872922007 no 2270 0.342942578507584 3170 16421196
SGTC_1319 1306-0155 43.7 µM -0.405122158180046 0.320100544656591 no 2271 0.342693859818994 3132 3122360
SGTC_980 1473-0395 201 µM -0.406084100066436 0.31971641610326 no 2272 0.342340403989682 3083 768876
SGTC_1843 st055809 45.5 µM -0.407480784446861 0.319159027641089 no 2273 0.341827452218043 3237 16413835
SGTC_2812 7970281 58.44 µM -0.407665032148547 0.319085528590423 no 2274 0.341759806457515 3264 2233435
SGTC_1376 2910-0861 41.3 µM -0.408538808356635 0.318737063604812 no 2275 0.341439072450938 3158 1112859
SGTC_516 3992-2719 87.3 µM -0.408678824777001 0.318681239455817 no 2276 0.341387687744519 3021 5350887 YDR037W KRS1
SGTC_1047 2043-3044 82 µM -0.408878641709718 0.31860158013869 no 2277 0.341314361906034 3136 669592
SGTC_154 3389-1638 511.116 µM -0.41026918246497 0.318047457410364 no 2278 0.340804248029539 3174 5238686
SGTC_1696 st025591 34.7925 µM -0.411242830323154 0.317659706382199 no 2279 0.340447242638744 3123 2787147
SGTC_1925 st057770 10.1 µM -0.41134809862925 0.317617795705398 no 2280 0.340408652688972 3123 5989122
SGTC_105 0111-0055 734.78 µM -0.411381800429363 0.317604378435625 no 2281 0.340396298413965 3196 5179370
SGTC_1130 3454-2858 15.9 µM -0.412599078806503 0.31711991956391 no 2282 0.339950188144837 3167 715628 YIL048W NEO1
SGTC_2798 7813637 45.45 µM -0.414389525702908 0.316407917451516 no 2283 0.339294429292948 3256 956368
SGTC_1712 st032288 53.4 µM -0.415275754113131 0.316055744831866 no 2284 0.33897002417562 3222 2883011
SGTC_1301 naphtanilide LB 4.81 µM -0.417457694132103 0.315189389266333 no 2285 0.338171831229502 3255 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1764 st044502 93.5 µM -0.417484538633415 0.315178736770853 no 2286 0.338162015546554 3244 8407
SGTC_1137 ixabepilone 100 µM -0.41794597291454 0.314995653410821 no 2287 0.33799330945747 3155 154225 A novel microtubule stabilizer.
SGTC_2252 omeprazole 400 µM -0.419540960193546 0.314363160295859 no 2288 0.337410413113068 3106 4594 A proton pump inhibitor.
SGTC_2840 9008771 71.43 µM -0.420231844640429 0.314089358598303 no 2289 0.337158046778929 3197 2992978
SGTC_1306 1185-0270 9.02 µM -0.420830450493891 0.313852210172025 no 2290 0.33693944720964 3244 1548076
SGTC_2144 5628481 200 µM -0.421302781434283 0.313665142067437 no 2291 0.336766999717558 3162 2818399
SGTC_2779 methotrexate 400 µM -0.4219098256738 0.313424790697721 no 2292 0.336545418944438 3254 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_337 1315-0038 354 µM -0.422258258560174 0.313286868944371 no 2293 0.336418261043782 3177 1626437
SGTC_3071 9117417 49.47 µM -0.42251787884392 0.313184119256813 no 2294 0.33632352678077 3137 45595590 YGL055W OLE1
SGTC_375 3970-0961 9.27 µM -0.422946663551645 0.313014451275449 no 2295 0.336167087943079 3176 2898222
SGTC_567 1080-0542 68.4 µM -0.425491655290539 0.312008226493959 no 2296 0.335239151742689 3238 5950415
SGTC_3034 9090421 49.47 µM -0.425793309707191 0.31188905277665 no 2297 0.335129231201861 3212 17173761
SGTC_561 1550-0330 72.9 µM -0.426047395092878 0.311788687293157 no 2298 0.335036655402088 3154 6812934
SGTC_2770 toltrazuril 17.5 µM -0.426765960160398 0.311504924798752 no 2299 0.334774901074351 3269 68591 Kills coccidiodes.
SGTC_1304 1165-0502 251 µM -0.427104609195887 0.311371230546832 no 2300 0.33465156796859 3164 767425
SGTC_2384 9036245 200 µM -0.428464617462003 0.31083456757081 no 2301 0.334156444272289 3177 6462766
SGTC_2894 9048625 32.47 µM -0.428584347917493 0.310787340850001 no 2302 0.334112869086188 3314 4092861
SGTC_2936 9038235 15.59 µM -0.429230631572444 0.310532473268183 no 2303 0.333877696621569 3145 4749415
SGTC_2232 chlorophetanol 41.5365 µM -0.42929847096603 0.310505725484127 no 2304 0.333853014713912 3258 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_897 1000-0139 31.4 µM -0.430039150361338 0.310213754880643 no 2305 0.333583581196441 3294 6151020
SGTC_629 3448-6466 76.7 µM -0.430294156136747 0.310113261064155 no 2306 0.333490838775487 3207 573744
SGTC_1940 st075990 51.1 µM -0.432231233232772 0.309350352488762 no 2307 0.332786680574659 3404 1084979
SGTC_2650 prasterone 100 µM -0.432474110032237 0.309254754484032 no 2308 0.332698432545318 3221 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1649 st011737 51.3 µM -0.432478326844119 0.309253094831435 no 2309 0.33269690047037 3217 1761035
SGTC_8 0354-0001 70 µM -0.433743461502359 0.308755339072953 no 2310 0.332237371156923 3187 4993152
SGTC_3166 9102297 49.47 µM -0.434474194012978 0.308467998896727 no 2311 0.331972065208654 3217 25237072
SGTC_3275 9138069 49.47 µM -0.435005092149644 0.308259311553934 no 2312 0.33177936563779 3252 17617007
SGTC_835 0312-0010 67.2 µM -0.435508353179723 0.308061545103205 no 2313 0.331596738562641 3139 1626196
SGTC_2856 9022925 19.48 µM -0.435781583155807 0.307954197273207 no 2314 0.331497603614058 3291 4944862
SGTC_1346 1488-2224 62.4 µM -0.435892165540488 0.307910755835563 no 2315 0.331457484800844 3285 3722427
SGTC_894 0960-0238 55.9 µM -0.437755383410202 0.307179210232783 no 2316 0.330781808474517 3286 6741907 YDL195W SEC31
SGTC_1427 4048-4900 550 nM -0.438367689780508 0.30693897078587 no 2317 0.33055988219298 3279 24132586
SGTC_1952 st077036 64.1 µM -0.43878975482017 0.306773421093749 no 2318 0.330406942261812 3233 2937007
SGTC_779 1360-0071 233 µM -0.439221554545031 0.306604093871135 no 2319 0.330250504168944 3359 7566
SGTC_449 xestospongin c 11.1929 µM -0.439719988675926 0.306408687752897 no 2320 0.33006996177405 3268 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1727 st034309 9.9045 µM -0.440895992326666 0.305947865473231 no 2321 0.329644147578724 3366 870305
SGTC_374 0880-0231 82.3 µM -0.441628576520209 0.305660954221446 no 2322 0.329379000808854 3222 6833587
SGTC_785 1270-0111 65.3 µM -0.442068648691708 0.305488660498693 no 2323 0.329219765171407 3156 6741994
SGTC_1004 4084-0029 199 µM -0.442086365442589 0.305481725072225 no 2324 0.329213355193815 3296 716894 YLR208W SEC13
SGTC_2987 9018338 71.43 µM -0.442578597845074 0.305289062939818 no 2325 0.329035284003797 3326 5055682
SGTC_2447 5741742 33.78 µM -0.443978584690408 0.304741396293791 no 2326 0.328529033524182 3274 1776504
SGTC_2823 7987624 58.44 µM -0.444443018765345 0.304559808937834 no 2327 0.328361158556449 3397 2239440
SGTC_474 dl-dihydrosphingosine 5 µM -0.44454346883936 0.304520540668469 no 2328 0.328324854293439 3310 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_288 1315-0019 35.1 µM -0.445501487509126 0.304146142154346 no 2329 0.327978692526902 3296 6811474
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.445868589149933 0.304002731360614 no 2330 0.32784608648445 3291 7104
SGTC_3072 9116419 49.47 µM -0.446227865134562 0.303862406909978 no 2331 0.327716328273282 3220 17170162
SGTC_2176 5809774 33.9695 µM -0.446624703196939 0.303707445215712 no 2332 0.327573028100283 3269 2870539
SGTC_2071 5230951 39.92 µM -0.446944185538706 0.303582715867834 no 2333 0.32745767990978 3304 1799272
SGTC_202 3594-0513 34.79 µM -0.449155071647972 0.302720189703225 no 2334 0.326659897622122 3225 708429
SGTC_3322 9139058 2.11 µM -0.451606699122042 0.301765029572538 no 2335 0.325776171538616 3344 4908926 YPR165W RHO1
SGTC_2009 4012297 12.05 µM -0.451769296344447 0.301701729224946 no 2336 0.325717595450723 3271 45595307
SGTC_1724 st037281 8.293 µM -0.453688707928918 0.30095493925891 no 2337 0.325026447769677 3172 574124 YDL195W SEC31
SGTC_1326 1431-2094 10.8 µM -0.454115086230131 0.300789160456432 no 2338 0.32487299773947 3133 616278
SGTC_414 piperonyl butoxide 100 µM -0.45484654431929 0.300504860551224 no 2339 0.324609821224189 3193 5794 A potent inhibitor of cytochrome P450.
SGTC_1562 morin hydrate 59.1 µM -0.455004938515883 0.300443312582228 no 2340 0.324552842975566 3347 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1755 st041960 45.185 µM -0.455747624142346 0.300154799757183 no 2341 0.324285735659312 3307 2257073
SGTC_1715 st032160 10.2275 µM -0.457698577410336 0.299397505895019 no 2342 0.323584505100116 3270 5289825
SGTC_1056 3448-1962 115 µM -0.461029391598259 0.298106603344886 no 2343 0.322388759119799 3288 715507
SGTC_2329 6138490 200 µM -0.461580427522282 0.297893286534375 no 2344 0.322191116519243 3343 720019
SGTC_2198 6589944 200 µM -0.463505672448891 0.297148533439961 no 2345 0.321500974927419 3277 5290268
SGTC_1888 azatryptophan 97.5 µM -0.465520987555557 0.296369851176778 no 2346 0.320779205410099 3294 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_912 3474-0017 2.18 µM -0.466593573833039 0.295955804529201 no 2347 0.320395342751927 3357 3360550
SGTC_2505 galangin 7.89 µM -0.46711794195366 0.295753481282189 no 2348 0.320207749087098 3133 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1621 st003705 32.4 µM -0.467449057028381 0.295625755921234 no 2349 0.320089315719757 3345 24207032
SGTC_3065 9113888 49.47 µM -0.468273496610621 0.295307844242498 no 2350 0.319794509511664 3392 16648368
SGTC_2870 9038528 12.99 µM -0.469547371275276 0.294816935763003 no 2351 0.319339216420298 3328 6463316
SGTC_1581 himbacine 57.9 µM -0.47029186015239 0.294530209063976 no 2352 0.319073256096735 3219 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_483 fpl-64176 144 µM -0.471821933747811 0.293941332702741 no 2353 0.318526946847676 3323 3423
SGTC_2100 5377183 190 µM -0.475238258828729 0.292628467388133 no 2354 0.3173085801991 3296 2844202
SGTC_444 curcumin 90.4 µM -0.476048866733802 0.292317357837452 no 2355 0.317019782190237 3343 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2467 5474540 200 µM -0.476252040531066 0.29223940429237 no 2356 0.316947414234931 3215 5413519
SGTC_1352 1496-0991 99 µM -0.478543131697109 0.291361030579704 no 2357 0.316131841551855 3233 3000039
SGTC_1282 0886-0010 32.4 µM -0.47944518878439 0.291015532283724 no 2358 0.315810976207982 3408 2836211 YNL267W PIK1
SGTC_3301 9125354 19.7965 µM -0.479863237509858 0.290855479719887 no 2359 0.315662321626 3314 41905162
SGTC_2257 7960413 200 µM -0.48035828887786 0.290665999444902 no 2360 0.315486324121248 3226 2974689 YIL048W NEO1
SGTC_3080 9117754 49.47 µM -0.481181399720652 0.290351082700511 no 2361 0.315193789653991 3429 9550191
SGTC_330 1488-0319 80.1 µM -0.482680043719589 0.289778122074827 no 2362 0.314661467551356 3315 6846614
SGTC_157 1348-1695 65.819 µM -0.485209111688448 0.288812415240577 no 2363 0.313764009654525 3342 5380510
SGTC_3103 9120822 49.47 µM -0.486052318947667 0.288490779563074 no 2364 0.313465035946886 3452 17141819
SGTC_158 k038-0087 26.446 µM -0.48615136366109 0.288453010711461 no 2365 0.313429925968824 3202 X158
SGTC_1293 1000-1278 195 µM -0.487728601403009 0.28785187484686 no 2366 0.31287104503841 3385 678847
SGTC_974 1326-0144 138 µM -0.488693201650289 0.287484526585227 no 2367 0.312529458771426 3274 5411856
SGTC_1049 3226-0134 66 µM -0.488985066458796 0.28737341954896 no 2368 0.312426134704994 3332 5702385
SGTC_1519 esterone 74 µM -0.489265290223583 0.287266763140994 no 2369 0.312326945599141 3211 698 A steroid.
SGTC_1310 1188-0297 994 nM -0.489541681544501 0.287161583759236 no 2370 0.312229126360743 3266 1588352
SGTC_1236 0330-0013 258 µM -0.490056804407487 0.286965604908575 no 2371 0.312046851595038 3264 4617066
SGTC_1180 1193-0155 285 µM -0.490373278063009 0.286845233715272 no 2372 0.311934891101643 3351 2921347
SGTC_1442 4112-3290 3 µM -0.490653543210334 0.286738654460542 no 2373 0.311835754781797 3276 704353
SGTC_1761 st044296 37 µM -0.491223722767216 0.286521884495579 no 2374 0.311634111055473 3246 1826700
SGTC_2816 7982706 58.44 µM -0.493505646689696 0.285655125370026 no 2375 0.31082767548801 3335 2981853
SGTC_66 0109-0187 42.4 µM -0.493801033663398 0.285543017734944 no 2376 0.310723351541749 3386 759417
SGTC_2584 androsterone 48.74 µM -0.49427695861833 0.285362434942789 no 2377 0.310555297706009 3368 2754130 A steroid.
SGTC_2671 danthron 100 µM -0.49610906615192 0.28466777662749 no 2378 0.309908731537131 3327 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.496893447025293 0.284370619300968 no 2379 0.309632096409575 3242 4000243
SGTC_108 0509-0257 621.132 µM -0.497141112364131 0.284276823782378 no 2380 0.309544772284506 3299 536624
SGTC_918 glabranin 770.725 nM -0.49724099033919 0.284239002300967 no 2381 0.309509559430478 3307 124049 Also referred to as licorice root.
SGTC_2357 9067248 200 µM -0.498097296835239 0.283914837582682 no 2382 0.309207732877724 3355 9150235
SGTC_1840 st055363 71 µM -0.498692532422391 0.28368960856584 no 2383 0.308998003088919 3309 676033
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.498736208670659 0.28367308544058 no 2384 0.308982616321346 3381 229346 A bile salt which induces apoptosis.
SGTC_1913 st060213 96.1 µM -0.498827911869751 0.283638394779398 no 2385 0.308950311161667 3422 688959
SGTC_258 haloperidol 50.781 µM -0.498842244808677 0.283632972915251 no 2386 0.308945262094237 3310 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1500 4488-1866 171 µM -0.504422668559038 0.281525792120938 no 2387 0.306982195873085 3435 2900003
SGTC_2044 5102272 200 µM -0.504476674141809 0.281505436439046 no 2388 0.306963224822627 3359 592666
SGTC_1025 k007-0731 70 µM -0.506730145928565 0.280656695681957 no 2389 0.306172087762319 3250 6256118
SGTC_491 tetrandrine 80.3 µM -0.50745510794356 0.280383911621851 no 2390 0.305917763711439 3356 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2179 6298986 200 µM -0.508369674514606 0.280039967610269 no 2391 0.305597057908046 3387 738374
SGTC_3248 9135562 49.47 µM -0.508874936289419 0.279850039923475 no 2392 0.30541994458072 3339 17650701
SGTC_3122 9126309 49.47 µM -0.509086191385424 0.279770647749359 no 2393 0.305345905190838 3399 17591206
SGTC_850 0388-0143 75.9 µM -0.509247463887841 0.27971004698364 no 2394 0.30528938875291 3284 67273
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.509450251040999 0.279633855454336 no 2395 0.305218330481921 3286 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_889 0919-1524 82.7 µM -0.51081409510107 0.279121691543191 no 2396 0.304740619218352 3355 3905452
SGTC_2277 7947813 106.88 µM -0.511564874696213 0.27883994629597 no 2397 0.304477786906431 3464 1246798
SGTC_1611 st001856 99.4 µM -0.511682797664679 0.278795705892936 no 2398 0.304436513697589 3318 647478
SGTC_2715 st079500 56.4 µM -0.511702342906993 0.278788373559904 no 2399 0.304429673075196 3303 28246688
SGTC_140 0062-0056 502.533 µM -0.511845568358356 0.278734645869434 no 2400 0.304379547811467 3271 3758964
SGTC_698 k064-0052 127 µM -0.512812833648005 0.278371930859942 no 2401 0.304041125812719 3416 5088751
SGTC_389 tpck 16.7 µM -0.514624828032654 0.277693070444971 no 2402 0.303407606024803 3361 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_233 rapamycin 362 pM -0.515261127217364 0.277454874087384 no 2403 0.303185279487876 3388 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2644 guaiazulene 100 µM -0.515950749210263 0.277196829353333 no 2404 0.302944403959191 3383 3515 A coloring agent.
SGTC_484 loperamide 105 µM -0.516567817169235 0.27696603266902 no 2405 0.302728943201633 3326 3955 An opioid-receptor agonist.
SGTC_1231 0242-0792 125 µM -0.517293074152341 0.276694891286363 no 2406 0.302475794021585 3307 3707635
SGTC_296 1222-0039 74.9 µM -0.517565633299107 0.276593027159097 no 2407 0.302380682459592 3333 5984176
SGTC_1279 0874-0590 65.2 µM -0.517642678664426 0.276564236158581 no 2408 0.302353799332509 3345 3523074
SGTC_432 NS 1619 61.3 µM -0.518175160878336 0.276365293619683 no 2409 0.302168031788358 3417 4552 A K+/calcium channel activator.
SGTC_3353 9151644 39.2805 µM -0.518300630221024 0.276318426801506 no 2410 0.302124266646371 3406 4909158
SGTC_1166 k206-0078 225 µM -0.52260435248809 0.274713213526932 no 2411 0.300624805514776 3378 5404595
SGTC_2150 5556613 200 µM -0.524730158035185 0.273922025285173 no 2412 0.299885394662501 3325 743190
SGTC_2122 5258151 111.688 µM -0.524887477078298 0.27386351863945 no 2413 0.299830707708304 3318 2173356
SGTC_2620 irigenin 100 µM -0.525086282605557 0.273789592089493 no 2414 0.299761605758289 3449 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_338 4055-0136 114 µM -0.525273038565629 0.273720155205355 no 2415 0.299696698635624 3329 2900563
SGTC_194 1486-1323 56.904 µM -0.527570769235278 0.27286655997853 no 2416 0.298898642814094 3365 5178754
SGTC_1274 0865-0114 173 µM -0.52837889182253 0.27256666069346 no 2417 0.298618192521224 3345 870624
SGTC_1264 0783-0040 158 µM -0.528915719473547 0.272367531129128 no 2418 0.298431958405964 3302 2855798
SGTC_1440 4100-1550 40 µM -0.531258274384603 0.271499436037719 no 2419 0.297619907812619 3387 742806
SGTC_542 3381-0244 89.3 µM -0.531943928284861 0.271245609992678 no 2420 0.2973824156629 3463 1112843
SGTC_3204 9114183 49.47 µM -0.532036917462613 0.271211194921431 no 2421 0.297350213369306 3326 17027248
SGTC_1942 st076330 65.2 µM -0.533264025953311 0.270757249025352 no 2422 0.296925413135793 3473 24208414
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.533543330835038 0.270653978415259 no 2423 0.296828762220708 3332 6708630 An antioxidant.
SGTC_2424 5537928 59.2 µM -0.533873443341309 0.270531947486247 no 2424 0.296714548359464 3354 5382802
SGTC_3165 9101544 49.47 µM -0.534763732387236 0.270202976176188 no 2425 0.296406622373977 3421 5002184
SGTC_854 0422-0053 192 µM -0.536040866628704 0.269731411034543 no 2426 0.295965153472077 3426 3596728
SGTC_2282 7944268 200 µM -0.536442433874198 0.269583222793626 no 2427 0.295826405531017 3482 2970414
SGTC_1192 1488-0095 21.4 µM -0.537033828240995 0.269365057953389 no 2428 0.295622123687148 3400 915875
SGTC_315 k915-0449 187 µM -0.537714722146044 0.269113986494983 no 2429 0.29538700689034 3406 20970215 YNL149C PGA2
SGTC_2925 9010536 32.5 µM -0.537750824742214 0.269100677374702 no 2430 0.295374542846857 3362 2994177
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.539566696112958 0.268431687904219 no 2431 0.294747944672628 3335 88881 An O-methylated flavonoid and antioxidant.
SGTC_1699 st031318 29.054 µM -0.540373957793676 0.268134551470677 no 2432 0.294469581858426 3429 5340658
SGTC_2805 7950783 58.44 µM -0.542050349316223 0.267518035479355 no 2433 0.293891910602484 3412 1178958 YDL195W SEC31
SGTC_1990 st072050 59.8 µM -0.542705462089104 0.267277303154552 no 2434 0.293666306444321 3330 17233948
SGTC_2673 kobusone 100 µM -0.542921235136486 0.267198037618229 no 2435 0.293592017254427 3456 6710676 An epoxy ketone and protein crosslinker.
SGTC_2047 4141938 200 µM -0.545607874843576 0.266212078879071 no 2436 0.292667755038897 3355 3807862
SGTC_3141 9094609 49.47 µM -0.545619731861215 0.266207731607052 no 2437 0.292663678965372 3273 25236309 YDL196W YDL196W
SGTC_3127 9126946 49.47 µM -0.546150308179104 0.266013237224307 no 2438 0.292481310342516 3363 27243249
SGTC_801 0866-0028 10.1 µM -0.546230049277081 0.265984012599528 no 2439 0.292453906459418 3414 6849771
SGTC_882 0843-0131 351 µM -0.546348212148569 0.265940709620727 no 2440 0.292413300716863 3468 5425421
SGTC_525 k781-2675 26.7 µM -0.547475014575847 0.26552795145729 no 2441 0.29202621565637 3468 3651118 YDL195W SEC31
SGTC_104 0074-0074 590.992 µM -0.548296812512072 0.265227124334164 no 2442 0.29174405785179 3343 3943124
SGTC_1433 4060-0023 7.6 µM -0.548946843540797 0.264989296792292 no 2443 0.291520964880176 3451 3840627
SGTC_251 melphalan 456.522 µM -0.550015892909135 0.264598398349737 no 2444 0.291154236436641 3428 460612 A DNA alkylator.
SGTC_1173 0443-0020 122 µM -0.550756241597727 0.264327861494581 no 2445 0.290900392332496 3372 5331295
SGTC_1648 st011736 69.8 µM -0.551104590613299 0.264200617175446 no 2446 0.290780989347923 3492 2855514
SGTC_1653 st012112 65 µM -0.551421740878626 0.264084796218553 no 2447 0.290672300237435 3468 720429
SGTC_2886 9058944 51.95 µM -0.551562168660275 0.264033521284073 no 2448 0.290624180947968 3295 4949929
SGTC_508 roscovitine 141 µM -0.55484358538974 0.262836811033153 no 2449 0.289500825993596 3438 160355 A CDKinase inhibitor.
SGTC_543 3844-1095 191 µM -0.554942845163849 0.262800654940373 no 2450 0.289466877359488 3426 4230703
SGTC_214 4373-3496 70 µM -0.555449762880234 0.262616046160446 no 2451 0.289293531517311 3519 3779166
SGTC_48 0382-0018 55 µM -0.556348290785651 0.262288984318932 no 2452 0.288986390389073 3583 762596
SGTC_3293 9120939 62.045 µM -0.557467700895438 0.261881813999133 no 2453 0.288603960511172 3462 934087
SGTC_473 2-arachidonoylglycerol 10 µM -0.557620968154811 0.261826090342222 no 2454 0.288551617584376 3326 5282280 An endocannabinoid.
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.558125790794104 0.261642594069566 no 2455 0.288379245182415 3454 140250 A respiratory chain inhibitor.
SGTC_1847 st056231 15 µM -0.558339672096011 0.261564870987837 no 2456 0.288306229753675 3438 5393180
SGTC_601 0986-0029 62.9 µM -0.558605757924118 0.261468193665379 no 2457 0.288215404761055 3454 24747981
SGTC_3162 9099653 49.47 µM -0.559073577288708 0.261298264722347 no 2458 0.288055753339744 3449 25237511
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.55910757279843 0.261285918533039 no 2459 0.288044153413032 3430 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1970 st070122 35.8 µM -0.559227618606128 0.261242323753414 no 2460 0.288003193221078 3522 102928
SGTC_2442 5158906 48.48 µM -0.559510917573923 0.261139458210734 no 2461 0.287906541188206 3461 1893835
SGTC_766 1391-0721 126 µM -0.560572389373769 0.260754224180019 no 2462 0.287544539157235 3472 1020919 YIL115C NUP159
SGTC_3022 9087993 49.47 µM -0.560730370644963 0.260696913928961 no 2463 0.287490679971431 3453 17173644
SGTC_550 4123-0385 25.7 µM -0.560754795450137 0.260688054016031 no 2464 0.287482353460055 3399 5731123
SGTC_2066 5222451 176 µM -0.560808100185609 0.260668718665448 no 2465 0.2874641820638 3435 2281147
SGTC_2024 5144227 134 µM -0.561135886917716 0.260549836048982 no 2466 0.287352452665094 3442 3475211
SGTC_1689 st020265 53.493 µM -0.561381990810176 0.260460596745738 no 2467 0.287268579187798 3477 5758320 YPR016C TIF6
SGTC_2011 4012611 177 µM -0.561794533277782 0.260311040756818 no 2468 0.287128008577608 3391 2049887
SGTC_2852 9023854 51.95 µM -0.562409933131 0.260088026625781 no 2469 0.286918376450249 3508 19798528
SGTC_1852 st056254 31.4 µM -0.562785129942696 0.259952107782615 no 2470 0.286790603585815 3359 442583
SGTC_2412 st077135 33.4 µM -0.563912260108138 0.259544013912007 no 2471 0.286406922938399 3555 13258915
SGTC_2035 5154463 94.595 µM -0.565616662128597 0.258927539324384 no 2472 0.285827199277572 3479 2769623
SGTC_1774 st048371 48.465 µM -0.566025203231036 0.258779884456734 no 2473 0.2856883238502 3362 4242727
SGTC_344 k064-0035 6.43 µM -0.567351970838755 0.258300665020863 no 2474 0.285237537125868 3356 5088750
SGTC_1873 rapamycin 2 nM -0.571008144092122 0.256982464019905 no 2475 0.283997061143647 3460 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2401 5128683 200 µM -0.572684259450083 0.256379327476665 no 2476 0.283429248531111 3388 708373
SGTC_196 k015-0023 18.111 µM -0.573482769327326 0.256092249813628 no 2477 0.283158931237909 3449 5211998
SGTC_120 rhodamine 6G 52.259 µM -0.573973303787018 0.255915977635187 no 2478 0.28299293335066 3419 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2065 5221596 34.26 µM -0.574362679211214 0.255776101759901 no 2479 0.28286120116036 3476 788581
SGTC_2002 4023503 131 µM -0.574736711190178 0.255641775323994 no 2480 0.282734687652272 3557 4736863 YCR052W RSC6
SGTC_2330 7979373 200 µM -0.575837250800276 0.255246751338042 no 2481 0.28236259616003 3422 1863007
SGTC_839 0122-0028 230 µM -0.576740668683895 0.254922720234177 no 2482 0.282057327518619 3410 759448
SGTC_844 0330-0132 15.3 µM -0.5768246023948 0.254892626457238 no 2483 0.282028974040896 3507 2828079
SGTC_3020 9089140 49.47 µM -0.579130648226296 0.254066539560352 no 2484 0.281250510757355 3502 17217859
SGTC_2713 st079149 53.4 µM -0.580082902146536 0.25372582708347 no 2485 0.280929356629508 3469 3103253
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.580343658411125 0.253632571442255 no 2486 0.280841445724504 3392 803109
SGTC_1443 4112-3303 14 µM -0.581483045243709 0.253225297797896 no 2487 0.280457470972543 3478 704433
SGTC_566 0958-0068 16.5 µM -0.583132004020476 0.252636487291719 no 2488 0.279902220291896 3517 6815365
SGTC_1744 st037937 38.9 µM -0.587791419765067 0.250976608023591 no 2489 0.27833615196546 3529 1016152
SGTC_1210 3013-0140 750 nM -0.588131976704729 0.250855514089111 no 2490 0.27822185565171 3534 905973
SGTC_645 0845-0943 5.41 µM -0.588848390266844 0.250600875496481 no 2491 0.277981490626631 3457 1885106
SGTC_2708 st078559 56 µM -0.589752027893217 0.250279886265615 no 2492 0.277678454356841 3454 17250902
SGTC_832 4083-0019 164 µM -0.592562693691175 0.249282879627386 no 2493 0.276736926050221 3559 1990758
SGTC_647 0140-0236 81 µM -0.5927480079975 0.24921721874257 no 2494 0.276674903711629 3504 990837
SGTC_1734 st037168 69.4 µM -0.595036492124888 0.248407117762006 no 2495 0.27590953916837 3454 708907
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.596260693196363 0.247974339471768 no 2496 0.275500542697552 3572 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_519 k048-0011 62.8 µM -0.596703593079574 0.247817865136928 no 2497 0.27535264663674 3489 6836379
SGTC_2379 9035213 200 µM -0.597026189944022 0.247703926450328 no 2498 0.275244947554718 3524 646551
SGTC_3009 9080819 71.4286 µM -0.599807552834669 0.246722732292996 no 2499 0.274317249582448 3484 17027216
SGTC_3306 9127676 59.7925 µM -0.599909909281386 0.246686663285462 no 2500 0.274283139005351 3478 41905287
SGTC_741 4582-0002 126 µM -0.601100439430281 0.246267344304561 no 2501 0.273886545362439 3489 2912688
SGTC_2201 6605497 169.863 µM -0.601754861994003 0.246037011701599 no 2502 0.273668662604479 3501 670741
SGTC_1148 3909-7663 27.7 µM -0.603077929593666 0.245571693951716 no 2503 0.273228423973991 3585 4084526
SGTC_1241 0364-0022 50.8 µM -0.603192224464712 0.245531519081897 no 2504 0.273190409871733 3468 4563895
SGTC_1984 st072354 53.1 µM -0.603577118970841 0.245396253882927 no 2505 0.273062414485461 3450 5762938
SGTC_990 3985-0011 41.3 µM -0.603640597269335 0.245373949268012 no 2506 0.273041307844438 3455 5399565 YGL099W LSG1
SGTC_2996 9066192 71.4286 µM -0.603729258017479 0.245342798022261 no 2507 0.27301182935021 3484 6472854
SGTC_3146 9095609 49.47 µM -0.60411243582886 0.245208191685404 no 2508 0.27288444608106 3496 17173999
SGTC_1816 st051957 91.6 µM -0.604210854096818 0.245173624793002 no 2509 0.272851732763601 3517 674121
SGTC_3300 9124615 50.48 µM -0.604519565724897 0.245065214754011 no 2510 0.272749132509486 3577 24824903
SGTC_638 3970-0837 4.09 µM -0.604878819016677 0.24493908850519 no 2511 0.27262975884698 3479 4118451 YLR208W SEC13
SGTC_1272 0839-0021 27 µM -0.60595415288635 0.244561770314782 no 2512 0.27227259903139 3516 5027250
SGTC_93 0109-0045 59.227 µM -0.606328338710796 0.244430547701202 no 2513 0.272148372049797 3582 88733
SGTC_3132 9126706 49.47 µM -0.607926361247995 0.243870567028782 no 2514 0.271618157455408 3562 850858
SGTC_1224 0823-0416 294 µM -0.607943473578701 0.243864574257323 no 2515 0.271612482468069 3553 3598164
SGTC_1221 2958-7315 257 µM -0.608480896149049 0.243676408275032 no 2516 0.271434286280131 3532 4562705
SGTC_2309 7664088 163.95 µM -0.609750023266461 0.243232364324683 no 2517 0.271013706058923 3555 704922
SGTC_1850 st056238 17 µM -0.612066313649977 0.242423066398896 no 2518 0.270246941995944 3542 5393177
SGTC_2515 chrysin 20.77 µM -0.612439910078417 0.24229267081237 no 2519 0.270123371640555 3508 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_212 3807-4682 38.772 µM -0.613473389895615 0.241932155592178 no 2520 0.26978168626403 3584 3125501 YBL034C STU1
SGTC_644 1498-1197 63.3 µM -0.614273721803798 0.241653170865546 no 2521 0.269517232189294 3565 6741615
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.61482105389168 0.241462479013976 no 2522 0.269336451806663 3466 6708514
SGTC_2196 6573537 42.6665 µM -0.61605147399068 0.241034096167096 no 2523 0.268930273816042 3582 2903087
SGTC_1449 4112-4002 201 µM -0.617366555051603 0.240576695058987 no 2524 0.268496488389112 3517 2059539
SGTC_1237 0330-0133 46.1 µM -0.617373949947441 0.240574124361554 no 2525 0.268494050144247 3502 X1237 YHR072W ERG7
SGTC_3150 9097574 49.47 µM -0.619318126437838 0.239898786817849 no 2526 0.267853402745132 3529 17217476
SGTC_642 0335-0876 158 µM -0.621226641606175 0.239236843763969 no 2527 0.267225256333924 3572 6812350
SGTC_1021 4476-0760 85.3 µM -0.621304966163623 0.239209699269707 no 2528 0.267199493393188 3458 746768
SGTC_1328 1441-0025 69.2 µM -0.621643815664485 0.239092285526348 no 2529 0.267088051611956 3513 4562601
SGTC_1120 ficusin 1.78878 µM -0.622402137074183 0.238829635976353 no 2530 0.266838737778133 3567 6199 A DNA cross-linker.
SGTC_580 1123-0028 41 µM -0.622450364482255 0.238812937439278 no 2531 0.266822885999041 3615 1677248 YPR107C YTH1
SGTC_737 1950-0117 57.9 µM -0.623020643936807 0.238615529011281 no 2532 0.266635477969449 3534 5393513
SGTC_300 r073-0011 5.04 µM -0.624814474164534 0.237995157871745 no 2533 0.26604641491611 3615 2735780
SGTC_489 paxilline 115 µM -0.625371846668478 0.237802578568578 no 2534 0.265863517667158 3550 105008 A toxic potassium channel blocker.
SGTC_2474 5321570 43.32 µM -0.625442690098491 0.237778107384018 no 2535 0.265840275537349 3536 2841384
SGTC_972 1319-0219 195 µM -0.625653694456643 0.237705229111596 no 2536 0.265771055873409 3517 23903702
SGTC_833 3852-0053 558 µM -0.626207035720819 0.237514170160206 no 2537 0.265589576505194 3603 3123681
SGTC_2344 7990960 76.95 µM -0.627017256374569 0.237234567430153 no 2538 0.265323961826564 3522 140813
SGTC_1827 berberine 7.24 µM -0.627189413250547 0.237175180328569 no 2539 0.26526754100311 3464 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1447 4239-0816 81.9 µM -0.627433990880835 0.237090825065083 no 2540 0.265187396263561 3492 1341554
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.627769603056572 0.236975098660664 no 2541 0.265077440766627 3543 6312947
SGTC_1247 0448-0043 5.84 µM -0.627831618645477 0.236953717731041 no 2542 0.265057125341609 3567 3089013 YGL099W LSG1
SGTC_13 0199-0087 65 µM -0.62785530621746 0.236945551317372 no 2543 0.265049365838639 3572 4589825
SGTC_2318 6029776 164 µM -0.628474683728925 0.236732072618462 no 2544 0.264846512999343 3594 818325
SGTC_89 0302-0250 142.109 µM -0.628635537339772 0.236676649070965 no 2545 0.264793844612541 3614 4203518 YLR208W SEC13
SGTC_2237 6667747 47.222 µM -0.632533523642173 0.235335747654154 no 2546 0.263519154949475 3454 729940 YDL015C TSC13
SGTC_256 clotrimazole 625 nM -0.634527128193698 0.23465157492539 no 2547 0.262868434168461 3559 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_575 k072-0246 11.9 µM -0.634966995811676 0.234500767750954 no 2548 0.262724970279446 3581 6796779
SGTC_2322 7413319 38.22 µM -0.635927907467832 0.234171508914617 no 2549 0.262411705996847 3593 1840400
SGTC_54 0159-0055 9 µM -0.636432549915154 0.233998694456077 no 2550 0.262247265468967 3643 3319099
SGTC_1863 st057641 20.1 µM -0.636745530635638 0.233891549928025 no 2551 0.262145305502155 3590 3921635
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.637506376800449 0.233631198390299 no 2552 0.26189752881123 3608 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3161 9100388 49.47 µM -0.637780132640058 0.233537562070722 no 2553 0.261808407042945 3601 25236368
SGTC_401 neomycin 50 µM -0.63919225231775 0.233054886883722 no 2554 0.261348935834852 3528 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_88 0180-0332 8.668 µM -0.639515146683409 0.232944596555403 no 2555 0.261243931659343 3620 3101745
SGTC_2783 7738165 71.43 µM -0.639863659236296 0.232825588417316 no 2556 0.261130620863723 3507 17201110
SGTC_1339 1486-1321 22.7 µM -0.64250721508039 0.231923982378079 no 2557 0.260271953068024 3572 3469382
SGTC_2569 tetrandrine 100 µM -0.643526921378615 0.231576723673876 no 2558 0.259941125966085 3529 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_345 1362-0200 395 µM -0.644581072366517 0.231218039779833 no 2559 0.259599351988142 3532 1419823
SGTC_559 1550-0661 158 µM -0.646555291295441 0.230547129443017 no 2560 0.25895990075938 3590 5830875
SGTC_1921 5740136 50 µM -0.647682743619552 0.230164469348123 no 2561 0.258595083813183 3601 1774243
SGTC_2600 tangeritin 87.95 µM -0.648270339064593 0.229965178932553 no 2562 0.258405057348198 3585 68077 A bioactive flavone.
SGTC_1657 st012939 43.4 µM -0.649458005345681 0.229562661954278 no 2563 0.258021190927975 3612 24207257
SGTC_2967 9089538 49.85 µM -0.651454817923189 0.228886804375994 no 2564 0.257376467084012 3608 728216
SGTC_1801 st050089 28.441 µM -0.651831940300554 0.228759285926586 no 2565 0.257254797181593 3621 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1868 st057644 42.7 µM -0.652071699897283 0.228678235447894 no 2566 0.257177459785401 3590 688665
SGTC_2307 7538926 6.34 µM -0.652108499886077 0.228665796678095 no 2567 0.257165590568206 3585 96582
SGTC_1097 itavastatin 7.23 µM -0.652934913475765 0.228386560584651 no 2568 0.256899119806951 3621 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1898 st060199 18.6 µM -0.653649431975518 0.228145287149114 no 2569 0.25666884463075 3610 688866
SGTC_3082 9117008 49.47 µM -0.654364816872967 0.227903864799686 no 2570 0.256438397951051 3583 41448529
SGTC_532 1548-0774 215 µM -0.654395173108963 0.227893623600929 no 2571 0.256428621692559 3696 5932993
SGTC_3196 9111891 49.47 µM -0.65508043722964 0.227662506860886 no 2572 0.256207983328292 3609 18891510
SGTC_707 0865-0008 204 µM -0.655508224849718 0.227518295282879 no 2573 0.256070296328731 3605 723043
SGTC_1457 k015-0032 57.3 µM -0.655655648811819 0.22746860908082 no 2574 0.256022855645338 3606 4302660
SGTC_3210 9128157 49.47 µM -0.657125024677394 0.22697372043553 no 2575 0.255550264661455 3556 17590849
SGTC_1862 st057513 3.81 µM -0.657741336376815 0.226766326346492 no 2576 0.255352177903644 3595 5393163
SGTC_385 1494-0393 12.4 µM -0.658371817174846 0.226554274920029 no 2577 0.255149620174505 3615 3090647
SGTC_1158 4092-0494 91.8 µM -0.658934591145983 0.226365090118452 no 2578 0.254968885961983 3666 1148199
SGTC_150 3970-0969 77.2 µM -0.661079599241572 0.22564483263104 no 2579 0.254280633802773 3630 6615640
SGTC_1867 st057372 64 µM -0.661217137003746 0.225598694053848 no 2580 0.254236536377478 3606 688837
SGTC_2139 5578692 56.4705 µM -0.661443664813141 0.225522714410875 no 2581 0.254163915660991 3564 650991 YMR113W FOL3
SGTC_627 1391-0720 175 µM -0.665188175649225 0.224268869144617 no 2582 0.25296507122219 3581 997839
SGTC_3076 9116187 49.47 µM -0.665190444217131 0.224268110718778 no 2583 0.252964345819387 3567 27241210
SGTC_3118 9124250 49.47 µM -0.666429519650532 0.223854081659271 no 2584 0.252568299676296 3551 1504786
SGTC_1164 k060-0068 93.7 µM -0.666792878088681 0.223732750207382 no 2585 0.252452221256142 3649 5963676
SGTC_1157 4092-0394 27.6 µM -0.668398498024199 0.223197054725647 no 2586 0.251939626994353 3705 3659885
SGTC_1667 st014849 34.6 µM -0.668454737360509 0.22317830440288 no 2587 0.251921682544953 3656 5348460
SGTC_2552 juarezic acid 87.02 µM -0.670914297302944 0.222359159157342 no 2588 0.251137563870683 3692 1549512
SGTC_1545 lovastatin 49.4 µM -0.671205984487756 0.222262127955921 no 2589 0.251044658398171 3665 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1113 artemisinin 1.17947 µM -0.673892161828535 0.221369694069376 no 2590 0.250189937848301 3641 2240 An anti-malaria and mitochondrial poison.
SGTC_1905 st060207 84.5 µM -0.674490759476595 0.221171100367696 no 2591 0.249999679274407 3580 1948547
SGTC_2320 7373003 200 µM -0.674741582003643 0.221087916563832 no 2592 0.24991998054831 3638 5415828
SGTC_512 prima-1 270 µM -0.675650176339617 0.220786736569628 no 2593 0.249631388114256 3641 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2738 aclarubicin 5.55 µM -0.67601424008389 0.220666123025506 no 2594 0.249515801997599 3542 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2629 bisabolol 100 µM -0.67604115627611 0.220657207246885 no 2595 0.249507257540424 3639 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2324 6149169 200 µM -0.677579828997741 0.220147877085632 no 2596 0.249019069506733 3571 2888231
SGTC_1223 0764-0573 147 µM -0.678309304691771 0.219906642460077 no 2597 0.248787800148146 3661 1609797
SGTC_598 3937-0236 20.2 µM -0.678879269676269 0.219718262988129 no 2598 0.248607180887313 3668 1379313
SGTC_1671 st016596 74.5 µM -0.679206653347548 0.219610101118827 no 2599 0.248503466112418 3681 2829167
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.679906742107486 0.219378906612157 no 2600 0.248281756177068 3677 368090
SGTC_849 0386-0493 241 µM -0.679913059591876 0.219376820988337 no 2601 0.248279755983781 3609 726119
SGTC_2040 5100729 123 µM -0.680594376040334 0.219151961343583 no 2602 0.248064093248571 3658 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_3318 9139014 38.6185 µM -0.680691405927476 0.219119948672555 no 2603 0.24803338770717 3647 16643984
SGTC_597 k018-0003 82.8 µM -0.680870978047378 0.219060710275716 no 2604 0.247976566656935 3722 6786234
SGTC_1379 2144-0755 36.5 µM -0.681310676836539 0.21891569852305 no 2605 0.247837464441286 3673 5392327
SGTC_934 2950-0684 338 µM -0.682146895170954 0.218640067870502 no 2606 0.247573035086247 3652 1121253
SGTC_2015 5119600 184 µM -0.68256867208542 0.218501119424151 no 2607 0.247439717796281 3641 2828786
SGTC_1202 1988-0068 29.6 µM -0.682722580815788 0.218450429032697 no 2608 0.247391079135335 3588 2850480
SGTC_1136 pergolide 1.05886 µM -0.682969796671544 0.21836902178293 no 2609 0.247312963996934 3635 47811 A dopamine receptor agonist.
SGTC_805 3852-0218 479 µM -0.683648317428644 0.218145677276744 no 2610 0.247098633137268 3615 6615355
SGTC_1897 st060201 15 µM -0.684135246492597 0.21798547900285 no 2611 0.246944883441174 3653 611878
SGTC_2364 9055074 200 µM -0.685441969907775 0.217555906132636 no 2612 0.246532533738096 3640 6470630
SGTC_2839 9003951 25.97 µM -0.685495626315534 0.217538277549123 no 2613 0.246515609807559 3629 2990634
SGTC_1818 st052136 56.3 µM -0.686710146847889 0.217139472612144 no 2614 0.246132700753931 3561 674169
SGTC_3317 9138495 8.753 µM -0.68806138409875 0.216696271598436 no 2615 0.245707063373038 3652 17020139
SGTC_78 0336-0123 156.75 µM -0.68834910062865 0.216601969205062 no 2616 0.245616484231435 3542 6765896
SGTC_2880 9042983 58.44 µM -0.68971342935355 0.216155118131957 no 2617 0.245187209465468 3661 6464714
SGTC_1093 fluphenazine 7.97 µM -0.690138897688655 0.216015876107457 no 2618 0.245053421936819 3705 6602611 An atypical antipsychotic.
SGTC_1996 st072960 66.8 µM -0.690771027627237 0.215809096402571 no 2619 0.24485472268138 3655 1719405
SGTC_948 3448-0295 75.3 µM -0.693110269290352 0.215044891930144 no 2620 0.244120176772165 3684 678569
SGTC_1290 0986-0249 10.2 µM -0.693823530618359 0.214812190284606 no 2621 0.243896442031354 3617 53329
SGTC_960 1222-0186 7.7 µM -0.699445756031185 0.212983066212878 no 2622 0.242136750649913 3681 3126296
SGTC_922 1866-0035 480 µM -0.701603330651498 0.212283545144806 no 2623 0.241463286975445 3671 3156169
SGTC_3142 9086498 49.47 µM -0.702470476280096 0.212002781040908 no 2624 0.241192903704335 3640 25236367
SGTC_3193 9111931 49.47 µM -0.702503036420255 0.211992242962422 no 2625 0.241182754386538 3720 17087244
SGTC_2411 st077133 39.94 µM -0.702696434390218 0.211929656088459 no 2626 0.241122475110825 3756 1403142 YNL221C POP1
SGTC_1933 st074711 15.9 µM -0.70309583392517 0.211800437817405 no 2627 0.240998014133412 3674 17250958
SGTC_2067 5224629 34.075 µM -0.704862117979365 0.211229542551841 no 2628 0.240448023407418 3670 2835000
SGTC_2768 sulfasalazine 50.2 µM -0.705004100877731 0.211183690270208 no 2629 0.240403842058127 3713 5384001 An antioxidant and salicylic acid derivative.
SGTC_2859 9028643 45.46 µM -0.705964813556079 0.210873588804973 no 2630 0.240105009721182 3643 17151580
SGTC_2254 7938975 95.19 µM -0.706677281784135 0.21064378889879 no 2631 0.239883525342037 3727 2969277
SGTC_2 0422-0095 29 µM -0.707262138055178 0.210455258883506 no 2632 0.23970179490012 3582 6790840
SGTC_970 1315-0089 19.5 µM -0.708428732110125 0.210079500060853 no 2633 0.239339527513306 3639 6811083 YLR033W RSC58
SGTC_2994 9053520 71.4286 µM -0.709661040331001 0.209683003169315 no 2634 0.238957178667011 3684 4647384
SGTC_2466 5983409 37.09 µM -0.710179359454532 0.209516364824106 no 2635 0.238796459387551 3696 2879657
SGTC_2753 fluvastatin 17.09 µM -0.710418615509798 0.209439470868257 no 2636 0.238722291336459 3704 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_262 fenpropimorph 62.5 µM -0.710443795468649 0.209431379304737 no 2637 0.238714486421858 3647 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_578 3460-0051 92 µM -0.711315493912954 0.209151372993589 no 2638 0.238444376212137 3753 2876744
SGTC_1789 tunicamycin 25 nM -0.711647781398413 0.209044693911919 no 2639 0.238341455498793 3673 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3062 9077494 49.47 µM -0.711843630294148 0.208981832706156 no 2640 0.238280805845862 3663 16459633
SGTC_1373 2887-0003 58.5 µM -0.712212812503535 0.208863367352986 no 2641 0.238166502060902 3694 776948
SGTC_1515 3460-0031 42.1 µM -0.712755969274975 0.208689147965697 no 2642 0.237998388039352 3659 2876596
SGTC_289 k017-0060 526 µM -0.714308687530195 0.208191580938192 no 2643 0.237518160701336 3688 5512909
SGTC_1828 st055811 49 µM -0.716151096593762 0.207602091832985 no 2644 0.236949027919787 3668 5877589
SGTC_2222 6885208 172.143 µM -0.716420799024356 0.207515881860472 no 2645 0.236865777936499 3659 609514
SGTC_2725 haloperidol 53.21 µM -0.716784542157278 0.207399645437134 no 2646 0.236753525558627 3663 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2689 tacrolimus 100 µM -0.717500003484327 0.20717112757716 no 2647 0.236532817134186 3715 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_874 0599-0792 117 µM -0.71894014229532 0.206711600067201 no 2648 0.236088900771281 3720 765305
SGTC_3003 9075612 71.4286 µM -0.719853598744511 0.206420442364817 no 2649 0.23580756996559 3704 6501993
SGTC_295 k015-0027 31 µM -0.720072230496518 0.206350791115545 no 2650 0.235740262108072 3672 3887424
SGTC_945 3381-0768 11.3 µM -0.720761316088885 0.206131354803382 no 2651 0.235528189907823 3710 1126236 YIL048W NEO1
SGTC_1206 3978-0017 132 µM -0.72112135946514 0.206016755606585 no 2652 0.235417425247672 3758 3873677
SGTC_3143 9086658 49.47 µM -0.722856217067934 0.205465092906384 no 2653 0.234884112448501 3777 25236626
SGTC_3326 9140064 16.379 µM -0.723535522875997 0.205249321488589 no 2654 0.234675469015939 3691 1868434
SGTC_1251 0490-5699 265 µM -0.72365093820384 0.205212674904884 no 2655 0.234640030294307 3734 3883818
SGTC_1062 mesoridazine 14.2 µM -0.724347797015854 0.204991491458168 no 2656 0.234426120000355 3712 4078 A neuroleptic.
SGTC_207 4185-0010 4.486 µM -0.72510883707879 0.204750098809638 no 2657 0.234192631718712 3770 3761753
SGTC_497 capsazepine 133 µM -0.72549585039031 0.2046274077747 no 2658 0.234073944833573 3714 2733484 A calcium channel blocker.
SGTC_91 0417-1751 58.384 µM -0.726127137534568 0.204427370894067 no 2659 0.233880417043946 3809 6795624
SGTC_3183 9108214 49.47 µM -0.726647764338717 0.204262486730218 no 2660 0.233720880091002 3639 4974831
SGTC_1122 capsaicin 818.572 nM -0.726654922710208 0.204260220203245 no 2661 0.233718686954112 3794 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_311 1315-0136 58 µM -0.726820331998837 0.204207851482783 no 2662 0.233668013072801 3749 6759207
SGTC_991 3996-0057 64.7 µM -0.726894524666103 0.20418436461946 no 2663 0.233645285793654 3724 715343
SGTC_1278 0874-0585 172 µM -0.727533781791226 0.203982064313781 no 2664 0.233449514324232 3775 766306
SGTC_459 nigericin 15.3 µM -0.729318837760984 0.203417795425244 no 2665 0.232903325903343 3754 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2026 5148700 152 µM -0.729530659423559 0.203350898955894 no 2666 0.232838560216417 3723 79838
SGTC_1987 st072290 61.9 µM -0.730146710856225 0.203156415261844 no 2667 0.232650255843058 3723 54697379
SGTC_639 0833-0042 114 µM -0.730609146246244 0.203010500202604 no 2668 0.232508961909837 3712 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2670 beta-carotene 100 µM -0.731323632041515 0.202785177227476 no 2669 0.232290749566137 3647 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3088 9117578 49.47 µM -0.732295188722253 0.202479023240143 no 2670 0.231994207657593 3778 678341
SGTC_2461 5755302 26.15 µM -0.733073152988194 0.202234072858634 no 2671 0.231756906747067 3719 2788904
SGTC_2743 auranofin 4.32 µM -0.733100069798675 0.202225600986541 no 2672 0.231748698786426 3681 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1571 st070080 73.4 µM -0.733131482913557 0.202215714203519 no 2673 0.231739119936137 3779 4315245
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.735106255888621 0.201594766159924 no 2674 0.231137392333216 3752 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1096 rimcazole 32.2 µM -0.736597300499586 0.201126679506461 no 2675 0.230683638542805 3672 18528119 A dopamine reuptake inhibitor.
SGTC_726 3448-4391 34.2 µM -0.737266924051142 0.200916675495854 no 2676 0.230480021155506 3794 1356692
SGTC_925 2064-1272 59.6 µM -0.737896122727355 0.200719469272927 no 2677 0.230288787640162 3736 6815817
SGTC_2533 agelasine 13.65 µM -0.73889156165813 0.200407711839438 no 2678 0.229986423367529 3775 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2854 9024559 71.43 µM -0.739826203286453 0.200115260187079 no 2679 0.229702728615779 3743 3163529
SGTC_3023 9089636 49.47 µM -0.739944402914477 0.200078293515037 no 2680 0.229666865071724 3814 17249241
SGTC_2008 4012253 172 µM -0.742049464671543 0.199420627887314 no 2681 0.229028683243758 3762 603940
SGTC_3013 9080133 71.4286 µM -0.742970968116694 0.199133140832048 no 2682 0.22874962870115 3794 17050193
SGTC_269 exalamide 29 µM -0.743150208236199 0.199077251215653 no 2683 0.228695372445137 3705 3316 A derivative of salicylamide.
SGTC_277 nystatin 15.5 µM -0.744564990463616 0.198636433804217 no 2684 0.228267369421198 3738 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1660 st012960 28.1 µM -0.745482838346293 0.198350766133594 no 2685 0.227989941042136 3736 24207266
SGTC_2624 nerol 100 µM -0.745494122859261 0.198347255525901 no 2686 0.227986531369855 3684 637566 A natural product oil.
SGTC_1396 3511-0007 98.6 µM -0.745952477897311 0.198204693142573 no 2687 0.227848061338985 3721 X1396
SGTC_3214 9129694 49.47 µM -0.746308420233484 0.19809402691039 no 2688 0.227740563055309 3711 17158655
SGTC_2611 pyromycin 23.93 µM -0.748631383992688 0.197372709648502 no 2689 0.227039705354345 3755 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1964 st076914 61 µM -0.749693103428001 0.197043558456792 no 2690 0.226719781057905 3798 24208661
SGTC_2687 chenodiol 100 µM -0.749806664205307 0.197008372350768 no 2691 0.226685577242517 3775 5702181 A cholesterol synthesis inhibitor.
SGTC_2539 epi(13)torulosol 80 µM -0.752143594149376 0.196285133710633 no 2692 0.225982355051912 3771 6708597
SGTC_2824 7998404 51.95 µM -0.752898411786279 0.196051875305666 no 2693 0.225755481299478 3748 837851
SGTC_1936 st074407 74.3 µM -0.75421716456226 0.195644749888923 no 2694 0.225359416248602 3793 809813
SGTC_2986 9022445 71.43 µM -0.757062566503339 0.194768067519351 no 2695 0.224506189672134 3684 6459286
SGTC_2022 5136654 200 µM -0.757412150066126 0.194660524171223 no 2696 0.22440148959216 3794 1713771
SGTC_748 act1.228 77.9 µM -0.757879338208918 0.194516858223104 no 2697 0.224261610282352 3712 4421505 YNR035C ARC35
SGTC_1505 k297-0037 20.6 µM -0.758125701661297 0.19444112450618 no 2698 0.224187867328484 3770 4089396
SGTC_1707 st032323 6.317 µM -0.758908765801959 0.194200524750083 no 2699 0.223953567440319 3686 3132057 YMR211W DML1
SGTC_2831 7999036 19.48 µM -0.761286244485298 0.193471146132842 no 2700 0.223243057394112 3821 2988270
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.762956387352689 0.192959769363939 no 2701 0.222744703019745 3707 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_433 pimozide 108 µM -0.763350202917934 0.192839308362876 no 2702 0.222627284730693 3706 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_169 k015-0017 16.025 µM -0.76364109894526 0.192750358077955 no 2703 0.22254057513369 3784 1840002
SGTC_77 0828-0286 12.516 µM -0.763744638596716 0.192718703738963 no 2704 0.222509716927654 3740 745345
SGTC_1626 st003712 1.76 µM -0.76534953419045 0.192228458300268 no 2705 0.222031717621292 3739 24207035
SGTC_1610 st001799 48.1 µM -0.76625112542779 0.191953385314102 no 2706 0.221763446631953 3710 621897
SGTC_3053 9095903 49.47 µM -0.767021270899153 0.19171860696416 no 2707 0.221534434415911 3850 17174018
SGTC_457 grayanotoxin iii 135 µM -0.767092064421543 0.191697034433227 no 2708 0.221513389878819 3713 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1637 st007924 17.4 µM -0.767210543445737 0.19166093428062 no 2709 0.221478172599959 3755 683336
SGTC_1647 st011722 22.4 µM -0.767415949572365 0.191598357605226 no 2710 0.221417124273853 3750 2854783
SGTC_3260 9137109 49.47 µM -0.768292396139898 0.191331490094853 no 2711 0.221156745555665 3644 17478346
SGTC_2519 cryptotanshinone 88.04 µM -0.768526095165028 0.191260370023191 no 2712 0.221087346785143 3731 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2626 ethyl orsellinate 100 µM -0.769208135314954 0.19105290195237 no 2713 0.220884880847061 3797 75653 A natural product.
SGTC_1039 k821-0043 94 µM -0.769959124217868 0.190824620251094 no 2714 0.220662070076025 3750 15992768
SGTC_1694 st024011 44.9 µM -0.770070125585084 0.190790892835064 no 2715 0.220629148023465 3820 2787533
SGTC_717 1532-0246 73.2 µM -0.770097425738135 0.190782598329971 no 2716 0.220621051463592 3787 9561992
SGTC_2485 5633444 17.78 µM -0.770466253635894 0.190670560395786 no 2717 0.220511682785608 3811 5724239
SGTC_429 1112-0049 25.5 µM -0.770851535991756 0.190553567267464 no 2718 0.220397468046197 3752 2836170
SGTC_2235 salicylic acid 500 µM -0.771058556808321 0.190490722452463 no 2719 0.220336111922888 3783 338 A COX inhibitor and kinase inhibitor.
SGTC_1837 st055472 66.5 µM -0.77224068306573 0.190132111073737 no 2720 0.219985945027678 3866 676091
SGTC_1787 fluconazole 80 µM -0.773096320755927 0.189872802685039 no 2721 0.219732689194788 3669 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_625 k213-0058 121 µM -0.774061119579581 0.189580673033294 no 2722 0.219447324201307 3852 3655420
SGTC_125 0133-0007 11.75 µM -0.774140432817771 0.189556670231092 no 2723 0.219423874669863 3870 26541
SGTC_2299 7976368 114.88 µM -0.774949004526157 0.189312076467109 no 2724 0.219184896773579 3839 2979718
SGTC_205 1486-1330 71.903 µM -0.775917940597531 0.189019228357586 no 2725 0.218898719472691 3773 4118834
SGTC_1986 st071812 45 µM -0.776204953171608 0.188932536202676 no 2726 0.218813990991254 3736 11838594
SGTC_1484 3473-2379 286 µM -0.776560706766002 0.188825114826474 no 2727 0.218708995789032 3905 671917
SGTC_2714 st079313 56.9 µM -0.777076180929599 0.188669531909113 no 2728 0.218556912975532 3776 2939799
SGTC_2332 7982454 138.89 µM -0.777945768847543 0.188407247820125 no 2729 0.218300492331128 3770 2981748
SGTC_2935 9038016 29.96 µM -0.780222961606799 0.187721469904533 no 2730 0.217629824569493 3807 6463195
SGTC_1824 st053723 68.6 µM -0.781371788430617 0.187376085945947 no 2731 0.217291929391753 3784 675225
SGTC_2926 9010726 65.15 µM -0.784263764402896 0.186508381183182 no 2732 0.216442678403063 3827 2994293
SGTC_838 0109-0203 71.4 µM -0.784630327538655 0.186398576028039 no 2733 0.21633517165117 3811 759422
SGTC_1619 st003326 88.7 µM -0.78646694172373 0.185849015586515 no 2734 0.215796989473529 3747 2849032
SGTC_2301 7769476 200 µM -0.78750692089894 0.18553827414157 no 2735 0.215492589297974 3866 977820
SGTC_3114 9122766 49.47 µM -0.788586643045961 0.18521599904081 no 2736 0.215176820087915 3825 17176985
SGTC_2873 9040596 71.43 µM -0.789985350947916 0.184799030405004 no 2737 0.214768161766964 3776 6463863
SGTC_203 k066-0004 30.888 µM -0.790125752024652 0.184757207706206 no 2738 0.214727165921153 3873 6795412
SGTC_2478 5763493 32.33 µM -0.790431969053499 0.184666012133473 no 2739 0.214637769091256 3769 1365576 YLR208W SEC13
SGTC_3007 9078383 71.4286 µM -0.793514312256956 0.183749608021412 no 2740 0.21373911700519 3805 6496995
SGTC_3202 9113761 49.47 µM -0.793563697899524 0.183734948390915 no 2741 0.213724736562512 3875 4798415
SGTC_2866 9034245 58.44 µM -0.795263989500161 0.183230678403952 no 2742 0.213229978050035 3793 6462273
SGTC_2402 5553605 200 µM -0.795660351941774 0.183113249986311 no 2743 0.21311473879092 3865 6758546
SGTC_3237 9133362 49.47 µM -0.795891628036743 0.1830447526097 no 2744 0.213047513874021 3762 43845137
SGTC_3290 9121031 71.43 µM -0.796666799038504 0.182815285695393 no 2745 0.212822285514858 3824 17014854
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.796879291835718 0.182752414730601 no 2746 0.212760569348294 3825 442882
SGTC_2919 7978188 46.38 µM -0.797156334642639 0.182670465409681 no 2747 0.212680121043619 3777 2980291
SGTC_2688 kanamycin b 96.69 µM -0.797451723753316 0.182583114527052 no 2748 0.212594364866963 3925 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_734 2023-0417 80 µM -0.797826684851957 0.182472270623177 no 2749 0.212485536764238 3820 3935732
SGTC_763 3453-1109 128 µM -0.798585220905707 0.182248164996975 no 2750 0.212265480025356 3817 1560353
SGTC_128 0906-2981 13.371 µM -0.799683183023942 0.181924082500068 no 2751 0.211947189415463 3753 6740226
SGTC_1805 st050013 60.3 µM -0.800212208935296 0.181768060100911 no 2752 0.211793928665816 3785 4037144
SGTC_2907 7721985 69.9 µM -0.80054980994001 0.18166853725503 no 2753 0.211696158319494 3847 3267881
SGTC_2346 9031566 143.75 µM -0.801831560542025 0.181290995057326 no 2754 0.211325199793877 3815 4771086
SGTC_1165 k072-0275 30.3 µM -0.803989968908266 0.180656342825279 no 2755 0.210701384131829 3818 6153523 YGL055W OLE1
SGTC_488 nitrendipine 139 µM -0.804431380967935 0.180526723077642 no 2756 0.21057394193878 3870 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2576 guaiol 23.12 µM -0.804672944272471 0.180455813210262 no 2757 0.210504218193082 3840 227829
SGTC_2739 tacrine 100.86 µM -0.805313406712495 0.180267892809898 no 2758 0.210319423594107 3868 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_453 enantio-paf c16 10 µM -0.806729522951339 0.179852821191702 no 2759 0.209911165524864 3766 13871343 A lipid and platelet activating factor
SGTC_410 α-linolenic acid 100 µM -0.80873400592265 0.179266323122928 no 2760 0.209334081693787 3928 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1765 st044815 90.4 µM -0.808803181053376 0.179246104444386 no 2761 0.20931418309009 3890 645695
SGTC_2147 5545932 89.7195 µM -0.811004951392891 0.178603314968206 no 2762 0.208681413654774 3888 797404
SGTC_2957 9076800 11.52 µM -0.812523022953858 0.178160972521776 no 2763 0.20824579067365 3820 16459615
SGTC_2955 9076254 12.21 µM -0.812977259983009 0.178028749257319 no 2764 0.208115548027428 3802 16459619
SGTC_1425 4048-4433 7.33 µM -0.813242064054711 0.177951696341084 no 2765 0.208039643373049 3894 23734946
SGTC_2245 6637752 200 µM -0.81381365812128 0.17778544511343 no 2766 0.207875854745944 3921 681890
SGTC_38 0929-0051 58.268 µM -0.813891219167219 0.177762893615489 no 2767 0.207853635721327 3871 1379719
SGTC_1672 st016598 6.51 µM -0.814159350235292 0.177684946254556 no 2768 0.207776834633486 3884 4665860 YNL267W PIK1
SGTC_2931 9014674 55.67 µM -0.815608124213538 0.177264151845851 no 2769 0.207362150697379 3867 2996810
SGTC_2354 9060492 162 µM -0.81825934553996 0.176495739352082 no 2770 0.206604557398608 3926 6471895
SGTC_2585 alliin 100 µM -0.819620917553531 0.176101930411062 no 2771 0.20621612265897 3887 87310 A garlic compound which reacts with lipids.
SGTC_3129 9127257 49.47 µM -0.820135309387189 0.175953297186858 no 2772 0.206069487630494 3859 837894
SGTC_869 0564-0080 44.1 µM -0.822118965793257 0.175380864938185 no 2773 0.205504596165259 3878 6843321
SGTC_303 1348-1668 34.2 µM -0.822208867070001 0.175354949738276 no 2774 0.205479016521816 3860 5380509
SGTC_582 0987-0078 156 µM -0.822612640208013 0.1752385868768 no 2775 0.205364154118233 3905 1625765
SGTC_2619 obliquin 87.91 µM -0.827276361551493 0.173898105881251 no 2776 0.204040219381874 3828 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2786 7743617 45.45 µM -0.828771594829131 0.173469719051296 no 2777 0.203616832195125 3833 583674
SGTC_2248 tofa 1.1 µM -0.829518735431239 0.173255913904697 no 2778 0.203405469837156 3809 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.829603310405327 0.173231722122886 no 2779 0.203381552248158 3858 66535 A nucleotide analog.
SGTC_1275 0867-0008 21.1 µM -0.829824203668269 0.173168548074501 no 2780 0.203319092106578 3839 3422836
SGTC_26 0302-0163 425.158 µM -0.830773721944668 0.172897159089456 no 2781 0.203050735142483 3921 3100915
SGTC_541 4513-1321 94 µM -0.831832459717528 0.172594873020036 no 2782 0.202751759611102 3886 747515
SGTC_2456 5770359 74.46 µM -0.832052021282996 0.172532226998445 no 2783 0.202689790863062 3897 3118787
SGTC_949 1165-0505 146 µM -0.833126243505686 0.172225935468846 no 2784 0.202386767082759 3920 6244267
SGTC_3130 9127414 49.47 µM -0.833203344134067 0.172203965224245 no 2785 0.202365028447359 3878 1494646
SGTC_767 0929-0023 86 µM -0.833530624768437 0.172110724732363 no 2786 0.202272766737411 3911 1204563
SGTC_531 3788-1495 174 µM -0.833754173039659 0.172047055557707 no 2787 0.202209762057314 3856 2896655
SGTC_2606 farnesol 9.78 µM -0.835310830447434 0.171604118174176 no 2788 0.201771360493818 3920 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_581 0958-0271 211 µM -0.836762612330845 0.171191679699105 no 2789 0.201363008428843 3892 4591145
SGTC_875 0709-0210 25.7 µM -0.838265678547866 0.170765340226043 no 2790 0.200940753633557 3867 6251364
SGTC_3203 9113543 49.47 µM -0.838578683940727 0.170676642903812 no 2791 0.200852888241422 3990 17018012
SGTC_427 1354-0053 47.3 µM -0.838955717225055 0.170569840960586 no 2792 0.200747079860871 4012 6813657
SGTC_1615 st002656 86.5 µM -0.840066734216509 0.170255372874089 no 2793 0.200435485260254 3885 1584458
SGTC_1111 tnp00062 510.699 nM -0.840331061439581 0.170180611040249 no 2794 0.200361395140338 3952 676306
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.843869776904237 0.169181753629885 no 2795 0.199371089290913 3914 551469
SGTC_1076 itraconazole 331 nM -0.844223810067762 0.169082029821298 no 2796 0.199272175906574 3894 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3157 9099274 49.47 µM -0.844367875535749 0.169041460371519 no 2797 0.199231933892885 3856 17217662
SGTC_1341 1486-1360 280 µM -0.845238289264158 0.168796481161908 no 2798 0.198988904114106 3870 3976547
SGTC_1962 st076595 64.5 µM -0.845698722870222 0.168666983757302 no 2799 0.198860417897569 3911 279619
SGTC_813 k007-0158 173 µM -0.847714144356357 0.168100896205496 no 2800 0.198298593605588 3908 6523916
SGTC_679 0422-0091 41.4 µM -0.848285802038694 0.167940552959365 no 2801 0.198139411344722 3889 627384 YHR062C RPP1
SGTC_622 1348-1566 26.3 µM -0.848372458779122 0.167916255360041 no 2802 0.198115287877455 3948 7340407
SGTC_333 3486-0131 40.1 µM -0.848438507502452 0.167897737542362 no 2803 0.198096902452352 3971 6744690
SGTC_3294 9122953 26.2835 µM -0.848779492703254 0.167802157792044 no 2804 0.198002001672344 3900 16459826
SGTC_2774 tamoxifen 10.92 µM -0.851430723231333 0.167060200900573 no 2805 0.197265065561939 3920 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_652 0437-0092 114 µM -0.858311645992606 0.165144435084462 no 2806 0.195360200200223 3869 3091274
SGTC_2791 5663188 71.43 µM -0.860031676872362 0.16466777974098 no 2807 0.194885790646695 3943 54690634
SGTC_1923 st058458 19.1 µM -0.860561058902117 0.164521256844782 no 2808 0.194739920490026 3939 3534982
SGTC_1263 0774-1208 64.8 µM -0.860881994965036 0.16443246898967 no 2809 0.194651519549009 3922 906585
SGTC_2191 5911152 200 µM -0.861762441073936 0.164189050643015 no 2810 0.194409128531317 3921 2875902
SGTC_1607 st000305 50.6 µM -0.861952241195779 0.164136606934463 no 2811 0.194356899737092 3928 5457690
SGTC_1989 st071868 50.2 µM -0.864368639461973 0.163469881283568 no 2812 0.19369270736625 3924 16414057
SGTC_2285 7945142 200 µM -0.864471870041666 0.163441437430411 no 2813 0.193664363365266 3977 2970608
SGTC_1419 3993-2473 62.6 µM -0.865022512646367 0.163289769280133 no 2814 0.193513216258505 3991 704026
SGTC_1013 4112-3890 241 µM -0.866150562409737 0.162979346630298 no 2815 0.193203800158168 3878 705171
SGTC_3017 9080681 49.47 µM -0.866572798263617 0.162863252294387 no 2816 0.193088061553801 3947 16451914
SGTC_1238 0333-0287 48.8 µM -0.868072268972564 0.162451405417439 no 2817 0.192677385497701 3916 7226
SGTC_2154 5570129 200 µM -0.86876685229136 0.162260860016443 no 2818 0.19248733357358 3953 673366
SGTC_795 0685-0265 78 µM -0.869203807949902 0.162141064334747 no 2819 0.192367832490478 3965 302754
SGTC_378 3970-0959 8.33 µM -0.870014220839324 0.161919034193502 no 2820 0.192146316362586 3957 6615653
SGTC_2747 doxorubicin 7.63 µM -0.871666043673021 0.161467095202546 no 2821 0.191695294923046 3838 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_412 gemfibrozil 100 µM -0.874521299375821 0.160687838372711 no 2822 0.190917213023753 3879 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2867 9039098 71.43 µM -0.879853155412594 0.159239253887945 no 2823 0.189469432254783 3908 6463460
SGTC_2297 7971671 152.32 µM -0.880571185475702 0.159044831470101 no 2824 0.189274980094888 3954 909016
SGTC_1732 st034308 51.822 µM -0.881164295532205 0.158884351231207 no 2825 0.189114450639257 3812 830119
SGTC_2262 9014885 67.46 µM -0.882702213253215 0.158468725008406 no 2826 0.188698593010326 3886 6457424
SGTC_1635 st007035 42.4 µM -0.885997228957528 0.157580641443549 no 2827 0.187809510212908 3929 3716403
SGTC_2842 9000675 19.48 µM -0.886340750457387 0.157488242991166 no 2828 0.187716968135976 4012 2989072
SGTC_3221 9128209 49.47 µM -0.886381363950097 0.157477321359746 no 2829 0.187706029032449 3988 16460723
SGTC_2860 9025725 38.96 µM -0.89009471740387 0.156480843319315 no 2830 0.186707514626518 3952 40546248
SGTC_2280 7785178 200 µM -0.893717217074618 0.155512755413454 no 2831 0.185736605563408 3948 2954328
SGTC_2518 prenyletin 46.28 µM -0.894047215829511 0.155424762321331 no 2832 0.185648314610937 3913 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_211 3455-0679 143.504 µM -0.894257651424195 0.155368667513626 no 2833 0.185592026303975 4017 748649
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.896014899948971 0.15490076783882 no 2834 0.185122402718551 3996 279621
SGTC_796 1234-0020 70.7 µM -0.900489993381445 0.15371339937033 no 2835 0.183929774084803 3892 46495034
SGTC_965 1291-5240 308 µM -0.903594184785219 0.15289331858218 no 2836 0.183105312977416 3985 2834598
SGTC_2204 7233102 200 µM -0.907014826457073 0.151993002226488 no 2837 0.182199478411819 3868 2172480
SGTC_1154 4088-0362 150 µM -0.907740237615357 0.151802526774423 no 2838 0.182007739793985 3975 6618304
SGTC_1201 1889-3372 45.9 µM -0.910439244133854 0.151095226279555 no 2839 0.181295454614787 3857 5392199
SGTC_364 0083-0097 67.7 µM -0.919236546692621 0.14880505221597 no 2840 0.178985929557298 4094 5207356
SGTC_3308 9128332 17.569 µM -0.919326130500992 0.148781851100093 no 2841 0.178962507060304 4016 17332805 YDL196W YDL196W
SGTC_1413 3910-0535 34.4 µM -0.920654437172934 0.148438119536113 no 2842 0.17861543562459 3989 2876951
SGTC_1817 st052116 64.4 µM -0.921095026343877 0.148324223790807 no 2843 0.178500408359747 4013 4361398
SGTC_1670 st016595 4.04 µM -0.923082948512206 0.147811057432752 no 2844 0.177981989965323 3996 597879
SGTC_867 0518-0118 155 µM -0.92316739772631 0.147789283892079 no 2845 0.177959988000461 3974 6848158
SGTC_3005 9076496 71.4286 µM -0.923300567809331 0.147754953013743 no 2846 0.177925296035453 3993 21368410
SGTC_1742 st038235 28.8875 µM -0.923328098231223 0.147747856413458 no 2847 0.177918124653107 4052 564103 YBR002C RER2
SGTC_2795 7780010 54.55 µM -0.923903553096921 0.147599571916784 no 2848 0.177768266505071 4002 953673
SGTC_1784 st039334 36.3 µM -0.92783298697444 0.146589691611667 no 2849 0.176747104997649 4085 3496984
SGTC_175 3793-3120 23.7 µM -0.930057948750452 0.146019928530915 no 2850 0.176170540845301 4016 5322297
SGTC_585 0kpi-0023 191 µM -0.930256923714023 0.145969048057498 no 2851 0.176119037640025 3940 64601
SGTC_3045 9092950 49.47 µM -0.930776536082397 0.145836232630297 no 2852 0.175984584752221 3957 44120432
SGTC_2353 9059630 146.67 µM -0.931286398973687 0.145705988188731 no 2853 0.175852717794593 4058 4779114
SGTC_2846 9008642 19.48 µM -0.932448075787715 0.145409530049575 no 2854 0.175552504574753 4090 2992898
SGTC_2676 harmalol 100 µM -0.93378669460298 0.145068420040821 no 2855 0.175206967115978 3957 5459187 A monoamine oxidase inhibitor
SGTC_1915 st067105 30.6 µM -0.93404387532351 0.145002946370029 no 2856 0.17514063052685 3967 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_143 4032-1194 15.74 µM -0.934347841759686 0.144925587534759 no 2857 0.175062246685315 4021 1806963
SGTC_455 paf C-16 10 µM -0.934441067039652 0.144901867460682 no 2858 0.175038211137398 3974 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1300 1094-0077 113 µM -0.935910701331587 0.144528281723732 no 2859 0.174659583454148 3972 5532636
SGTC_1956 st077085 54 µM -0.936149705985861 0.144467587381761 no 2860 0.174598056939086 4053 24208685
SGTC_2815 7968870 71.43 µM -0.936484960067894 0.144382479802357 no 2861 0.174511776311931 4015 2977326 YHR190W ERG9
SGTC_1766 st045414 44.774 µM -0.93848346715998 0.143875840094525 no 2862 0.1739980046917 4050 253960
SGTC_2979 9012552 45.46 µM -0.939943547236955 0.143506455566212 no 2863 0.173623259235991 4049 17100905
SGTC_2377 9073351 62.6 µM -0.940192677399097 0.143443492312961 no 2864 0.17355936859176 3983 7337946 YHR072W ERG7
SGTC_3242 9133940 49.47 µM -0.940823422998432 0.143284165886095 no 2865 0.173397677709333 4048 17248444
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.941491764415827 0.14311547320876 no 2866 0.173226453852712 4021 688662
SGTC_3232 9132874 49.47 µM -0.943255778705587 0.142670871898575 no 2867 0.172775044480403 3978 3784940
SGTC_1669 st015249 58.4 µM -0.948557289820199 0.141340306948783 no 2868 0.171422911063857 4099 722793
SGTC_526 4469-0568 170 µM -0.949033168450819 0.141221284406044 no 2869 0.171301871421289 3969 2901964
SGTC_1048 3161-0300 24.5 µM -0.950683722344845 0.140808989186619 no 2870 0.170882476870101 4026 2165101
SGTC_2043 5101342 149 µM -0.954152976316179 0.139945061719022 no 2871 0.170003106713472 4044 678451
SGTC_2085 5307070 144.047 µM -0.955916162306208 0.139507369571282 no 2872 0.169557296373766 3970 2840351
SGTC_74 000s-0487 160.283 µM -0.957059882924246 0.139223951480521 no 2873 0.169268515343391 3937 677548
SGTC_2086 5274770 176.623 µM -0.957429150443688 0.139132529391544 no 2874 0.169175345481394 4083 689278
SGTC_3137 9097352 49.47 µM -0.962198793472399 0.137955348271926 no 2875 0.167974877545803 4060 44120435
SGTC_1487 3970-0795 2.82 µM -0.963874673689298 0.137543346961575 no 2876 0.167554381367023 4088 3765103
SGTC_2945 9067681 61.76 µM -0.965541665247055 0.137134364915158 no 2877 0.167136788752429 4116 16456930
SGTC_3095 9117207 49.47 µM -0.966633405290379 0.136866966539374 no 2878 0.166863664460604 4029 17015229
SGTC_3270 9137563 49.47 µM -0.970733787899037 0.135865849607997 no 2879 0.165840430913719 4034 17015724
SGTC_2312 7706453 155.7 µM -0.971447572965872 0.135692091224584 no 2880 0.165662724149298 4061 976098
SGTC_2761 levamisole 97.89 µM -0.972815452783294 0.135359530523448 no 2881 0.165322515581271 4018 26879 An alkaline phosphatase inhibitor.
SGTC_1199 1638-0010 4.46 µM -0.97374160269349 0.135134681189163 no 2882 0.165092427538522 4057 3111136
SGTC_2417 cerulenin 830 nM -0.974585181233142 0.134930101406258 no 2883 0.164883033607056 4090 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3025 9087895 49.47 µM -0.974796873165316 0.134878796467653 no 2884 0.164830514227538 4061 17173641
SGTC_2495 cafestol 54.53 µM -0.975116391291601 0.134801384484751 no 2885 0.164751264398563 4083 16667697 An anti-infammatory.
SGTC_1985 st071382 65.5 µM -0.977239856659964 0.134287691591345 no 2886 0.164225210206612 4050 6123237
SGTC_246 cycloheximide 667 µM -0.977917561507643 0.134124029658364 no 2887 0.164057549343871 3949 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_576 1073-0113 22.7 µM -0.978693291851068 0.133936863366607 no 2888 0.163865773794216 4203 5439563
SGTC_1230 0170-0365 3.77 µM -0.978765463411001 0.133919459122624 no 2889 0.163847938988398 4111 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2692 st077426 47.7 µM -0.980454388169321 0.133512616944747 no 2890 0.163430936984876 4088 25238571
SGTC_927 2425-1185 123 µM -0.982864759477905 0.132933460309462 no 2891 0.162837002045837 4015 730375
SGTC_159 3970-0959 50 µM -0.984979273830198 0.132426817477025 no 2892 0.162317125881415 4153 6615653
SGTC_2203 7227154 166.4 µM -0.985126920913601 0.132391490640967 no 2893 0.162280865652481 4052 896304
SGTC_2971 9092186 9.93 µM -0.987645348311069 0.13178991821855 no 2894 0.16166318437422 4092 25236400
SGTC_3287 9117173 37.0625 µM -0.989822854864101 0.13127130340626 no 2895 0.161130355868938 4049 2789709
SGTC_1668 st014914 51.6 µM -0.990925343123872 0.131009262888845 no 2896 0.160861018165226 4093 2839556
SGTC_3238 9133470 49.47 µM -0.991416763496322 0.130892578127138 no 2897 0.160741059004765 4092 3534688
SGTC_3 0833-0587 95.581 µM -0.995831480102043 0.129847551176532 no 2898 0.159666016014426 3990 5382644
SGTC_2677 mitomycin C 100 µM -0.996466726777775 0.129697655908278 no 2899 0.15951171299346 4108 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2652 actinonin 100 µM -1.00066577763707 0.128709845951794 no 2900 0.158494208862198 4094 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2756 carbadox 75.1 µM -1.00362550317441 0.128016726389907 no 2901 0.15777957856278 4057 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2367 9070478 135.38 µM -1.00475198353579 0.12775360552733 no 2902 0.157508145034636 4055 572802
SGTC_3048 9093155 49.47 µM -1.00510428314068 0.127671393356672 no 2903 0.157423318945186 4060 25236002
SGTC_360 0957-0399 1.01 µM -1.00537809461 0.127607522478232 no 2904 0.157357411834008 4118 6752301 YPR165W RHO1
SGTC_1078 idebenone 36.1 µM -1.00728455745907 0.127163425511073 no 2905 0.156899024289902 4143 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_758 0868-0029 16 µM -1.00742464595361 0.127130835357014 no 2906 0.156865376272141 4124 762687
SGTC_1910 st062352 60.4 µM -1.00795096109088 0.127008445465805 no 2907 0.156739002461506 4017 2245730
SGTC_3208 9114115 49.47 µM -1.00945476815871 0.126659200521406 no 2908 0.156378291870153 4115 650895
SGTC_995 3931-2021 34.6 µM -1.00948067765183 0.126653189153665 no 2909 0.156372081885925 4092 730143
SGTC_1112 tnp00069 1.16933 µM -1.01039275497011 0.12644170095617 no 2910 0.156153578797892 4114 145826
SGTC_144 4161-2749 112.381 µM -1.01135772616613 0.126218215963779 no 2911 0.155922623230318 4038 797501 YMR168C CEP3
SGTC_1135 dihydrocapsaicin 536.708 nM -1.01251378795121 0.125950837532877 no 2912 0.155646228790564 4018 107982 A Capsaicinoid.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.01282959707477 0.125877864715653 no 2913 0.155570780503636 4146 688788
SGTC_1768 st044301 37.178 µM -1.01484911022391 0.125411920616542 no 2914 0.155088879792134 4117 3931349
SGTC_2890 9046729 58.44 µM -1.01699930073753 0.124917151195324 no 2915 0.154576881030926 4046 903329
SGTC_1213 1315-0166 115 µM -1.01704055103041 0.124907672650439 no 2916 0.154567069533401 4196 768401
SGTC_172 1112-0046 2.638 µM -1.01858088848117 0.124554091598827 no 2917 0.15420099061471 4089 2802135 YIL048W NEO1
SGTC_1700 st030840 7.9285 µM -1.02082893232072 0.124039314880415 no 2918 0.153667747132009 4159 5499307
SGTC_1080 nisoldipine 24.4 µM -1.02211452161987 0.123745599426827 no 2919 0.153363350452977 4106 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2741 miltefosine 3.04 µM -1.0233671040473 0.12345989363953 no 2920 0.153067153467101 4089 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.02364118012942 0.12339744035542 no 2921 0.153002393550414 4073 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1372 2752-0194 270 µM -1.02446744057514 0.123209295639627 no 2922 0.152807270988002 4038 823334
SGTC_814 3342-0569 96 µM -1.03253691158946 0.121382391318265 no 2923 0.150910332639341 4184 4346283
SGTC_1406 3909-7906 11.9 µM -1.03265120491129 0.121356653173298 no 2924 0.150883578094362 4135 X1406
SGTC_1693 xanthone 101.9 µM -1.03283633157222 0.121314971943209 no 2925 0.150840249106963 4171 7020 An insecticide.
SGTC_3334 9142812 21.919 µM -1.0339561404285 0.12106306181658 no 2926 0.150578333886403 4120 45283678
SGTC_2639 lactacystin 53 µM -1.03564300103124 0.120684283859499 no 2927 0.150184361489484 4181 3870 A proteasome inhibitor.
SGTC_166 k072-0058 166.424 µM -1.03625089731496 0.120547987842369 no 2928 0.150042553676868 4041 5846229
SGTC_2784 7567673 72.73 µM -1.03647283158766 0.120498255127602 no 2929 0.149990803917668 4099 3471247
SGTC_2078 5212016 200 µM -1.0380740330349 0.120139873919209 no 2930 0.149617794779227 3979 1899708
SGTC_3117 9124945 49.47 µM -1.04036249070595 0.119628975787869 no 2931 0.149085760697921 4037 17592065
SGTC_1469 k284-2957 126 µM -1.04105500876316 0.119474673606246 no 2932 0.148925009401057 4117 23884841
SGTC_688 0527-0193 473 µM -1.04132340385859 0.119414909401266 no 2933 0.1488627391303 4192 4007154
SGTC_1573 oleylamine 1.06 µM -1.04362612569979 0.118903023347193 no 2934 0.148329200338599 4117 5356789 An amine of the fatty acid oleic acid.
SGTC_398 bronopol 33.3 µM -1.04363502691466 0.118901047653323 no 2935 0.148327140419217 4042 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_3074 9116018 49.47 µM -1.04380129195482 0.11886414809557 no 2936 0.148288666876176 4192 17027303
SGTC_376 3970-0862 59.1 µM -1.04460889562686 0.118685029932691 no 2937 0.148101883269438 4186 3135186
SGTC_2587 piperic acid 92.2 µM -1.0463031821753 0.118309874554501 no 2938 0.147710538345662 4136 5370536
SGTC_106 0092-0003 11.579 µM -1.04792677288699 0.117951160285979 no 2939 0.147336173047626 4057 1072148
SGTC_1365 1672-3266 55.4 µM -1.0482739447351 0.117874556494564 no 2940 0.147256205237275 4172 6415873
SGTC_2311 7694451 200 µM -1.04998418509364 0.117497704192245 no 2941 0.146862691970611 4128 2163142
SGTC_2313 7726885 200 µM -1.05055188444518 0.117372800139382 no 2942 0.146732224756324 4182 726423
SGTC_1747 st037496 66.6 µM -1.05213147009069 0.117025757817657 no 2943 0.146369617736251 4111 723305
SGTC_3057 9095946 49.47 µM -1.0546974079068 0.116463560410862 no 2944 0.145781868835098 4178 24540043
SGTC_3265 9137266 49.47 µM -1.05519156118577 0.116355511708537 no 2945 0.145668861437099 4073 17224265
SGTC_231 b-estradiol 524 µM -1.0560271772604 0.116172962570314 no 2946 0.145477899301271 4135 450 A steroid.
SGTC_3250 9135583 49.47 µM -1.05658991780673 0.116050140555092 no 2947 0.145349391928914 4195 7699353
SGTC_3184 9108758 49.47 µM -1.05832139416687 0.115672812073628 no 2948 0.144954471238769 4170 902885
SGTC_1114 scopoletin 1.73284 µM -1.05893951142123 0.115538321434816 no 2949 0.144813664201601 4186 5280460 A coumarin with genotoxic properties.
SGTC_2302 7771753 200 µM -1.05925798974949 0.115469069951264 no 2950 0.144741150842007 4163 2203047
SGTC_361 000s-0510 1.45 µM -1.06230908759686 0.11480711885477 no 2951 0.144047695104995 4106 660
SGTC_64 000l-0018 272.079 µM -1.06233503678305 0.114801500649583 no 2952 0.144041806979863 4083 6811119
SGTC_3257 9139206 32.98 µM -1.06545654538873 0.114127095558799 no 2953 0.143334690019169 4158 4910041
SGTC_3244 9134489 49.47 µM -1.06714113822086 0.113764312194946 no 2954 0.142954053826558 4166 16584271
SGTC_2393 9031399 185.94 µM -1.06835794099092 0.113502780935502 no 2955 0.142679540734715 4217 1526623 YDL150W RPC53
SGTC_2195 6536160 144.242 µM -1.06992087172892 0.113167484680198 no 2956 0.142327463713413 4114 3834386
SGTC_2482 5981709 142.65 µM -1.07370111426593 0.112359430863439 no 2957 0.141478330905418 4113 877755
SGTC_1171 0368-0077 21.4 µM -1.07604750870768 0.111859950598088 no 2958 0.140953004781313 4120 3239779
SGTC_1684 st024538 14.6195 µM -1.07721623340728 0.111611755836134 no 2959 0.140691837319965 4126 6732859
SGTC_2724 maprotiline 69.64 µM -1.07786380844568 0.111474404130508 no 2960 0.140547269332624 4092 4011 A tricyclic antidepressant.
SGTC_1474 0330-0125 5.35 µM -1.07928619916465 0.111173137520577 no 2961 0.140230081604469 4183 X1474
SGTC_533 1222-0222 6.71 µM -1.08029303374987 0.110960239617693 no 2962 0.140005855423203 4205 3982874
SGTC_1504 k297-0033 30 µM -1.08302147313822 0.110384772128822 no 2963 0.13939944599341 4051 4388117
SGTC_3131 9127911 49.47 µM -1.08364244023716 0.110254100627387 no 2964 0.139261682898668 4230 45595681
SGTC_447 ml7 120 µM -1.08484233604277 0.110001918233104 no 2965 0.138995745562542 4199 4216 Selective myosin light chain kinase inhibitor.
SGTC_2711 st079103 59.1 µM -1.08529379355251 0.109907142532443 no 2966 0.138895776938716 4129 54693780
SGTC_2737 bleomycin 30.5 nM -1.08559471081628 0.109844002710124 no 2967 0.138829170436016 4234 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1944 st076371 56.9 µM -1.08653104518988 0.109647703335662 no 2968 0.138622056753109 4143 24208455
SGTC_1119 parthenolide 318.541 nM -1.09206732566098 0.108492186709852 no 2969 0.137401754925842 4284 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1067 clotrimazole 1.36 µM -1.09282098711913 0.10833556465094 no 2970 0.137236202548089 4218 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1991 st073000 8.92 µM -1.09414074741132 0.108061690894343 no 2971 0.136946626867904 4251 4301969 YIL048W NEO1
SGTC_2117 5521686 200 µM -1.09731768614296 0.107404464614338 no 2972 0.136251271078324 4150 803312
SGTC_2675 theaflavin digallate 100 µM -1.09749783242734 0.107367283527408 no 2973 0.136211913884134 4127 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1409 3909-8004 61.9 µM -1.09780210521788 0.107304504563847 no 2974 0.136145456003246 4214 2119279
SGTC_1861 st057647 17.4 µM -1.09904660037869 0.107048010064283 no 2975 0.135873870047763 4282 688668
SGTC_2194 5927483 104.545 µM -1.10090112393498 0.106666607679228 no 2976 0.135469846425479 4228 760979
SGTC_3356 9151811 4.48 µM -1.10152204646098 0.106539127819759 no 2977 0.135334757359373 4200 1859254 YPR165W RHO1
SGTC_2603 homopterocarpin 100 µM -1.10332912849005 0.106168746804084 no 2978 0.134942130735864 4186 101795 A weak amylase inhibitor.
SGTC_336 4111-0029 111 µM -1.10344260848423 0.106145518929579 no 2979 0.134917500917483 4194 3131175
SGTC_1225 1216-0074 20.6 µM -1.10425726519269 0.105978877098381 no 2980 0.1347407774926 4213 4241466
SGTC_1252 0493-0875 34.8 µM -1.10691790436119 0.105435948075156 no 2981 0.134164712066983 4185 3960963
SGTC_893 0958-0369 48.9 µM -1.1073618065398 0.105345561743244 no 2982 0.134068765987792 4115 6819948
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.10759818274471 0.105297454246508 no 2983 0.13401769430849 4241 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2740 felodipine 17.08 µM -1.11032226327565 0.104744193646755 no 2984 0.133430091408232 4230 3333 L-type calcium channel blocker
SGTC_885 0865-0106 16.8 µM -1.11128972371298 0.104548209974833 no 2985 0.133221830631078 4133 2793380
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.11142249333961 0.104521334859988 no 2986 0.133193267385756 4183 688667
SGTC_384 k007-0144 5.16 µM -1.11559077811951 0.103680137753638 no 2987 0.132298670658223 4146 6824886
SGTC_1344 1488-0097 29.1 µM -1.11598594708056 0.103600644769145 no 2988 0.132214074990507 4250 747966
SGTC_724 3910-0327 137 µM -1.11725624959548 0.103345407768058 no 2989 0.131942388037188 4263 2885483
SGTC_2654 protoveratrine a 100 µM -1.12009864502223 0.102775950365959 no 2990 0.131335863993073 4212 5702278 A heart drug and vasodilator.
SGTC_9 0092-0002 10.449 µM -1.12243207016592 0.102310169273922 no 2991 0.130839387563111 4202 759368
SGTC_3004 9076122 71.4286 µM -1.12284428161896 0.102228046480937 no 2992 0.130751817457033 4241 44782551
SGTC_3285 9112818 20.8695 µM -1.12481953387731 0.101835192346829 no 2993 0.130332757575092 4198 17017947 YPR165W RHO1
SGTC_3273 9137859 49.47 µM -1.12752506417096 0.101298879678873 no 2994 0.129760274747703 4305 2377234
SGTC_1371 2421-0008 32.7 µM -1.12866079201823 0.101074360569274 no 2995 0.129520477526693 4200 2827552
SGTC_956 1185-0240 191 µM -1.1307917478195 0.100654076526706 no 2996 0.129071377029292 4199 1416193
SGTC_96 0929-0093 37.281 µM -1.13195104914502 0.100425965978487 no 2997 0.128827507428641 4229 6991579
SGTC_1614 st002383 48.6 µM -1.13224514724466 0.100368157640775 no 2998 0.128765692073431 4248 1947235
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.13309786407231 0.100200683702676 no 2999 0.128586579121071 4226 521171
SGTC_1429 4049-0205 9.46 µM -1.13432681077261 0.0999596770485538 no 3000 0.128328743464219 4241 22774478
SGTC_2120 5538279 151.968 µM -1.13557401215718 0.0997155235897037 no 3001 0.128067445156762 4191 2058197
SGTC_723 4182-0001 115 µM -1.14325338013066 0.0982217974264132 no 3002 0.126466702530698 4243 744821 YLR208W SEC13
SGTC_318 1488-0629 67.2 µM -1.14489137826535 0.0979053196988314 no 3003 0.126127077953599 4285 3662576
SGTC_3179 9107801 49.47 µM -1.15243693606865 0.0964570902646959 no 3004 0.124570785171631 4245 4818259
SGTC_3154 9100113 49.47 µM -1.15505202827922 0.0959588630192909 no 3005 0.124034560608648 4255 25237525
SGTC_784 4579-0127 173 µM -1.15534735885596 0.0959027158045268 no 3006 0.12397410474151 4270 1948547
SGTC_2263 7948595 193.29 µM -1.15570901484648 0.0958339919504636 no 3007 0.123900099773155 4254 2971371
SGTC_3278 9139605 49.47 µM -1.15848325751902 0.0953080195243812 no 3008 0.123333440088888 4254 7958859
SGTC_2246 7293507 91.5585 µM -1.15950623623182 0.0951146089126949 no 3009 0.123124948014652 4292 887656
SGTC_2536 dehydroabietamide 32.04 µM -1.16284577807828 0.0944852269740853 no 3010 0.12244603998159 4349 3983547
SGTC_3327 9140648 26.9345 µM -1.16303765075247 0.0944491594687324 no 3011 0.122407113423357 4278 8029710
SGTC_518 1021-0119 62.6 µM -1.16443067944699 0.0941876075162431 no 3012 0.122124760309455 4226 1097762
SGTC_244 nsc-207895 1.295 µM -1.1652938640989 0.0940258062342577 no 3013 0.121950030985701 4016 42640
SGTC_3107 9121808 49.47 µM -1.16698839192803 0.0937087689385551 no 3014 0.121607528690584 4193 662681
SGTC_2131 toluylene red 5.2905 µM -1.16751376846444 0.0936106341970437 no 3015 0.121501475671766 4223 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1009 4106-0057 9.87 µM -1.16754280879197 0.0936052119872656 no 3016 0.121495615459752 4254 2928005
SGTC_2817 7995342 71.43 µM -1.16820770595577 0.0934811304065644 no 3017 0.121361496448038 4264 18879975
SGTC_1302 1159-0335 255 µM -1.16903672608498 0.0933265907927707 no 3018 0.121194417411768 4269 649284
SGTC_3051 9093778 49.47 µM -1.16953767410563 0.0932332994112891 no 3019 0.121093535813279 4330 17217378
SGTC_2187 6125751 200 µM -1.17010691883221 0.0931273728174853 no 3020 0.120978972249605 4259 874498
SGTC_959 1222-0044 107 µM -1.17082749586764 0.0929934134860827 no 3021 0.120834061640673 4254 6083612
SGTC_727 3032-0951 202 µM -1.17312642879077 0.0925669811023289 no 3022 0.120372554790677 4303 3652836
SGTC_1351 1496-0003 46.5 µM -1.17494706832321 0.0922302958219322 no 3023 0.120007946542193 4279 3891978
SGTC_596 1155-0152 116 µM -1.17541310508188 0.0921442589634975 no 3024 0.119914741495952 4262 280313
SGTC_1612 st002233 45.4 µM -1.17596401422452 0.0920426301341686 no 3025 0.119804628224424 4262 1035021
SGTC_2948 9070189 9.45 µM -1.17682907863218 0.0918832151076792 no 3026 0.119631866898081 4214 6473636 YDL196W YDL196W
SGTC_1268 0828-0275 2.46 µM -1.18077679959919 0.0911583201007953 no 3027 0.118845701456197 4326 745337
SGTC_1260 0700-1617 7.75 µM -1.18090676542974 0.0911345276147653 no 3028 0.118819881714446 4260 2853078
SGTC_402 epigallocatechin gallate 10 µM -1.18348221718059 0.0906639961810243 no 3029 0.118309045048001 4214 65064 An antioxidant.
SGTC_732 3970-1727 52.7 µM -1.18593885883016 0.0902168537357056 no 3030 0.117823222926406 4349 1275699
SGTC_423 5-fluorouracil 457 µM -1.18606500246905 0.0901939381582023 no 3031 0.11779831509107 4200 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1121 fusaric acid 630.51 nM -1.19126775251822 0.0892525559891068 no 3032 0.11677424456698 4236 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2089 5281248 129.67 µM -1.19340321903784 0.0888682893219863 no 3033 0.116355747448837 4268 2737878
SGTC_1872 amphotericin b 148 nM -1.19363898397808 0.0888259402030277 no 3034 0.116309608823884 4295 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2391 6285546 200 µM -1.19542341050053 0.0885059009380779 no 3035 0.115960821796399 4287 846083
SGTC_2475 5812728 15.03 µM -1.19707718688034 0.0882100616972473 no 3036 0.115638235465164 4220 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2098 5376439 882.5 nM -1.19737823883787 0.0881562867839103 no 3037 0.115579580792841 4317 2844116
SGTC_2940 9060638 45.86 µM -1.20126076829451 0.0874649647065923 no 3038 0.114825031771289 4276 4027022
SGTC_1836 st055642 81 µM -1.20392141537076 0.0869935524867961 no 3039 0.114309976836084 4289 8571
SGTC_2278 7948257 134.34 µM -1.20524162649499 0.0867603437749643 no 3040 0.114055018504907 4295 1247028
SGTC_667 1498-1044 59 µM -1.20587476261899 0.0866486693187822 no 3041 0.113932891486334 4298 6739982
SGTC_247 mechlorethamine 29.705 µM -1.20910706457261 0.086080219990553 no 3042 0.113310857734603 4211 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3292 9120825 59.784 µM -1.21222548965259 0.0855344464151137 no 3043 0.112713038389674 4294 24824900
SGTC_1296 1068-0102 11.9 µM -1.2127819221903 0.0854373349875778 no 3044 0.112606604419791 4287 767053
SGTC_599 1935-0052 86.5 µM -1.21575353379855 0.0849201119769177 no 3045 0.112039412177795 4289 9557311
SGTC_2070 5230947 200 µM -1.21717187605245 0.0846740719446215 no 3046 0.111769414112725 4402 2835538
SGTC_2531 methyl deoxycholate 70.07 µM -1.22026914066885 0.0841386480638428 no 3047 0.111181432050417 4250 16667744 Haematoxylin.
SGTC_1695 st026914 34.495 µM -1.2210274570547 0.0840079461083728 no 3048 0.111037812033866 4296 3289191
SGTC_3304 9125678 46.087 µM -1.22252647799509 0.0837500263638988 no 3049 0.110754298601841 4234 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2661 dactinomycin 12.96 µM -1.22335870316339 0.0836070917285136 no 3050 0.110597121967829 4266 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_395 anisomycin 6.25 µM -1.22553894225641 0.0832335049213038 no 3051 0.110186113453081 4310 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2148 5546263 113.568 µM -1.22807688186228 0.0828002081412863 no 3052 0.109709054236082 4304 792097
SGTC_1481 3346-2004 36 µM -1.22927877949886 0.0825956039867521 no 3053 0.109483650350014 4384 2770522
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.23013854426622 0.0824494762091361 no 3054 0.109322614242272 4291 689007
SGTC_396 dithiazanine 1.25 µM -1.23248056631043 0.0820524075886802 no 3055 0.108884810851121 4299 10578 An antihelmenthic.
SGTC_3350 9150499 3.57 µM -1.23349760210975 0.0818804277198941 no 3056 0.108695085397797 4317 4910996 YPR165W RHO1
SGTC_1036 k216-0215 33.5 µM -1.23731225311202 0.0812377934160287 no 3057 0.10798559030695 4268 622330
SGTC_2902 5787006 60.46 µM -1.23901810765551 0.0809516513811107 no 3058 0.10766939613687 4264 591003
SGTC_677 0929-0063 136 µM -1.23959434716298 0.080855164394539 no 3059 0.107562736276357 4328 1539583
SGTC_285 1486-1325 46 µM -1.24618712993076 0.0797574238718677 no 3060 0.106347851436745 4365 22310230
SGTC_2887 9044784 58.44 µM -1.24870031392227 0.0793419434577975 no 3061 0.105887353007733 4285 6465546
SGTC_2928 9011484 9.79 µM -1.25012767356935 0.0791067024988421 no 3062 0.105626456066948 4327 2994751
SGTC_263 alizarin 107.927 µM -1.25181040798951 0.0788300524267196 no 3063 0.105319478355674 4357 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1967 st070177 51.4 µM -1.25435380591513 0.0784132970222194 no 3064 0.104856717472754 4362 5729214
SGTC_1126 isoteolin 1.0172 µM -1.25456508932022 0.0783787518951918 no 3065 0.104818341651774 4274 133323
SGTC_399 oxolinic acid 75 µM -1.25963478948456 0.0775533052253084 no 3066 0.103900569723988 4316 4628 A DNA gyrase inhibitor.
SGTC_2451 5856223 45.7 µM -1.26372364082118 0.0768923823013006 no 3067 0.103164618370384 4310 2179896
SGTC_1128 3448-9350 235 µM -1.26451660361346 0.0767647047698406 no 3068 0.103022332537635 4360 619386
SGTC_2110 5483698 200 µM -1.26790178276398 0.0762214584472668 no 3069 0.102416513694196 4316 2848765 YHR062C RPP1
SGTC_1900 st060200 72.8 µM -1.26999668694262 0.0758867413184064 no 3070 0.1020429051443 4340 688945
SGTC_1190 1486-1332 13 µM -1.27063202319592 0.0757854508448968 no 3071 0.101929794489195 4342 4150046
SGTC_3068 9116768 49.47 µM -1.27129897777447 0.0756792303448497 no 3072 0.101811152938071 4313 41904888
SGTC_1292 0kpi-0043 232 µM -1.27135936865112 0.0756696179773367 no 3073 0.101800415241669 4363 3333905
SGTC_2522 biochanin a 4.94 µM -1.2721991067677 0.0755360539004456 no 3074 0.101651192463106 4355 5280373 A possible chelator.
SGTC_2050 5263056 171 µM -1.27583039254013 0.0749605490825705 no 3075 0.101007740683407 4331 763468 YGL055W OLE1
SGTC_2544 sphondin 68.51 µM -1.27808887906557 0.0746043031609701 no 3076 0.10060904483799 4310 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1321 1326-2144 215 µM -1.27875742066566 0.0744990979540716 no 3077 0.100491246138972 4341 3513030
SGTC_3177 9107506 49.47 µM -1.28190607661133 0.0740051311701307 no 3078 0.0999377980314397 4312 8897194
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.28436263670819 0.0736214824605842 no 3079 0.0995075499153468 4354 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2289 7946404 165.07 µM -1.28691658850365 0.0732242378992726 no 3080 0.099061681355483 4341 1246120 YPR165W RHO1
SGTC_3040 9091894 49.47 µM -1.28709243146051 0.0731969475446194 no 3081 0.0990310365714529 4209 25236966
SGTC_355 1311-2252 105 µM -1.28711548206223 0.0731933707301236 no 3082 0.0990270199743859 4329 5338538
SGTC_1380 2291-0730 164 µM -1.28729008006441 0.0731662823021051 no 3083 0.0989965999171335 4365 2999191
SGTC_1597 7-benzyloxygramine 47.5 µM -1.29056429638781 0.0726597157102114 no 3084 0.098427401581139 4258 260807
SGTC_2802 7925815 54.55 µM -1.29216240198472 0.0724134441183668 no 3085 0.0981504545975625 4329 1262923
SGTC_2556 citropten 84.59 µM -1.29420561603698 0.0720995124539362 no 3086 0.0977972037199369 4376 2775 A potential DNA crosslinker.
SGTC_1417 3966-0327 90.4 µM -1.30377559343389 0.0706429945633219 no 3087 0.0961550532618676 4454 651118
SGTC_1150 3909-7983 10.9 µM -1.30397896303175 0.0706122896196025 no 3088 0.0961203775847902 4361 23965914
SGTC_781 4335-2806 94.4 µM -1.30431978260926 0.0705608553417023 no 3089 0.0960622865168573 4425 845254
SGTC_2874 9043904 71.43 µM -1.30457142363143 0.0705228977963707 no 3090 0.0960194120761952 4307 4463428
SGTC_2985 9022375 71.43 µM -1.30939412823055 0.0697984699909182 no 3091 0.0952004397163254 4417 4939335
SGTC_681 1642-0006 26.6 µM -1.31151155379857 0.0694822225254681 no 3092 0.0948424964315036 4387 4446530
SGTC_676 falcarinol 140 µM -1.31329676751468 0.0692164507865247 no 3093 0.0945414836768167 4411 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2084 5306078 60.6385 µM -1.31359683188453 0.0691718560217579 no 3094 0.094490957718034 4314 679340
SGTC_2186 6124449 200 µM -1.31645644764603 0.0687479776674316 no 3095 0.0940104435426477 4382 3834182 YLR033W RSC58
SGTC_2861 9024595 19.48 µM -1.3213358977958 0.0680293292600809 no 3096 0.0931946947450726 4302 16482810
SGTC_2020 4017018 200 µM -1.32247784885687 0.0678619824951286 no 3097 0.0930045403872116 4427 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_438 sphingosine 6.67 µM -1.32469600744164 0.0675378320663625 no 3098 0.0926359989671526 4306 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_479 n-linoleoylglycine 10 µM -1.32484746627846 0.0675157423531376 no 3099 0.0926108739192231 4418 6433346 An anti-infammatory.
SGTC_2351 9026858 72.31 µM -1.32997539683264 0.0667711422366631 no 3100 0.0917631888353832 4284 1409300
SGTC_1891 st059073 26.2 µM -1.33165647121892 0.0665284300816109 no 3101 0.0914865495562612 4461 688754
SGTC_843 0310-0051 143 µM -1.33332387113563 0.0662883674390518 no 3102 0.0912127716314097 4409 2065037
SGTC_2093 5331342 194.4 µM -1.34522209751578 0.0645947558800753 no 3103 0.0892767610967967 4442 33839
SGTC_2646 retinol 96.75 µM -1.35143687230373 0.0637235993437301 no 3104 0.0882777645223225 4401 445354 A vitamin A analog and teratogen.
SGTC_2833 9001315 45.46 µM -1.35330404105294 0.0634636622210285 no 3105 0.0879792593722566 4339 2989378
SGTC_1478 0453-0656 35.7 µM -1.35485389742379 0.0632485270401995 no 3106 0.0877320553085452 4415 5258496
SGTC_2884 9058502 51.95 µM -1.35823060652201 0.0627817734342165 no 3107 0.0871952608299233 4415 6471554
SGTC_469 w7 172 µM -1.36285372700899 0.0621470900824322 no 3108 0.0864643072781223 4500 45115570 A P450 inhibitor.
SGTC_3182 9108849 49.47 µM -1.36443123365545 0.0619316717672849 no 3109 0.0862159416526964 4417 17133045
SGTC_2837 9008476 45.46 µM -1.36576458074687 0.0617500497643565 no 3110 0.0860064334164157 4388 2992805
SGTC_1167 k781-0610 148 µM -1.37244513872011 0.0608463106803397 no 3111 0.0849624531917295 4450 4525169
SGTC_890 0929-0006 47.2 µM -1.37275563919804 0.0608045593539812 no 3112 0.0849141628779807 4415 1378169
SGTC_1303 1160-0052 261 µM -1.37336844740652 0.0607222240780472 no 3113 0.0848189168029013 4360 3562476
SGTC_740 k014-0057 261 µM -1.37735292516162 0.0601890051284062 no 3114 0.084201579795596 4415 4012779
SGTC_250 brefeldin a 552.239 µM -1.37744134982062 0.0601772134930511 no 3115 0.0841879180325994 4323 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_955 1216-0110 33 µM -1.37901589464484 0.0599675469299986 no 3116 0.0839449266449004 4388 3619719
SGTC_2088 5278280 127.392 µM -1.38441137442911 0.0592534209785365 no 3117 0.0831162640327027 4463 791502
SGTC_1389 3405-0187 19 µM -1.38527666145469 0.059139517809729 no 3118 0.0829839436277367 4409 799890
SGTC_2790 5423970 71.43 µM -1.39042956188701 0.0584647618220425 no 3119 0.0821992374220145 4446 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_404 fumagillin 50 µM -1.39175426051867 0.058292277283793 no 3120 0.0819984125093422 4432 12015870 A methionine aminopeptidase binder.
SGTC_3181 9108277 49.47 µM -1.3933889672842 0.0580799789019344 no 3121 0.0817511000782791 4392 17097298
SGTC_909 3448-9333 149 µM -1.39577988947666 0.0577705660188008 no 3122 0.0813903940671313 4362 3344074
SGTC_1770 st043884 66.3 µM -1.3975697302592 0.0575397893751784 no 3123 0.0811211567318218 4446 670149
SGTC_141 0443-0274 32.331 µM -1.41142046431173 0.0557783524252203 no 3124 0.0790603361721752 4386 1627241
SGTC_314 1671-0008 2.74 µM -1.41583420067161 0.0552260734120225 no 3125 0.078412026794926 4326 3913060
SGTC_2953 9074162 66.49 µM -1.41962057935438 0.0547557438561175 no 3126 0.0778590854424365 4432 16451992
SGTC_1664 st014217 9.02 µM -1.42062038766267 0.0546320814035425 no 3127 0.0777135741078956 4510 3982782
SGTC_16 erodoxin 22.806 µM -1.4222259909507 0.0544339526844144 no 3128 0.0774803279237266 4475 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2525 harmine 47.85 µM -1.4233493952709 0.0542956647636695 no 3129 0.0773174472228202 4428 5280953 A monoamine oxidase inhibitor
SGTC_2705 st078069 42.8 µM -1.42548295210412 0.0540337952547023 no 3130 0.0770088223039499 4468 1530061
SGTC_2389 9091542 195.52 µM -1.4263377216626 0.0539291630547083 no 3131 0.076885440546955 4423 3626624 YOL127W RPL25
SGTC_2192 5915882 198.485 µM -1.42774807619091 0.0537568725515656 no 3132 0.0766821914662798 4419 2876149
SGTC_1082 camptothecin 424.86 nM -1.42865930221589 0.0536457881536635 no 3133 0.0765510902606775 4318 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2127 5253358 187.912 µM -1.43389231931212 0.0530113656031247 no 3134 0.075801497020227 4373 20612
SGTC_2778 tioconazole 65.09 nM -1.43566221326153 0.0527981448210952 no 3135 0.0755492412305223 4353 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_731 3966-0296 387 µM -1.43762027817471 0.0525630482399167 no 3136 0.0752709120327826 4453 660956
SGTC_1155 4088-0394 48.2 µM -1.43971084631786 0.0523129604393011 no 3137 0.0749746117205209 4461 2326248
SGTC_2109 5483026 200 µM -1.44240258857529 0.0519923486393507 no 3138 0.0745944170156778 4469 759335
SGTC_2445 5742597 35.57 µM -1.44976376652248 0.0511235316486344 no 3139 0.0735622034188657 4476 1774255
SGTC_1340 1486-1359 257 µM -1.45079231030684 0.0510030611254997 no 3140 0.0734188507800531 4414 4309068
SGTC_1002 4049-0206 172 µM -1.452755570475 0.0507737371873157 no 3141 0.0731458158927943 4427 4662749
SGTC_902 1120-0002 2.07 µM -1.45588894509169 0.0504094365658657 no 3142 0.0727116610881426 4454 3280475
SGTC_963 1269-2853 151 µM -1.45758449689571 0.0502131740798332 no 3143 0.0724775527061605 4455 3668223
SGTC_522 1273-0010 11.6 µM -1.45825538429652 0.0501356863066143 no 3144 0.0723850814801322 4488 5705015
SGTC_1791 st048313 56.1 µM -1.47251401164507 0.0485112413612307 no 3145 0.0704410630606595 4493 1204976
SGTC_2900 5328528 85.29 µM -1.47556961151011 0.0481686617087365 no 3146 0.0700297340119116 4484 795359
SGTC_992 3909-8734 162 µM -1.47748402186913 0.0479550150620348 no 3147 0.069772969113385 4497 4288319
SGTC_2032 5185112 25.99 µM -1.47955091856495 0.0477252033058775 no 3148 0.0694965665672458 4369 5718189
SGTC_1488 4013-0813 75.9 µM -1.49029602184247 0.0465446633276974 no 3149 0.0680732090219204 4474 2910057
SGTC_976 1348-1067 47.6 µM -1.49933364507875 0.0455699680178707 no 3150 0.066893549096266 4509 5310671 YGL099W LSG1
SGTC_711 k292-0785 179 µM -1.50090923854198 0.045401734424025 no 3151 0.0666895191643048 4443 4146315
SGTC_2382 9035899 200 µM -1.50206769084824 0.0452783599110258 no 3152 0.0665398139823187 4493 6462679
SGTC_1521 st012942 49.4 µM -1.50539949865212 0.0449250270516868 no 3153 0.0661106989567402 4422 24207259
SGTC_2163 5671233 125 µM -1.50556318673778 0.0449077255574443 no 3154 0.066089672381364 4458 701023
SGTC_2642 cholecalciferol 100 µM -1.50575193408221 0.0448877820101463 no 3155 0.0660654332471614 4502 9821465 A vitamin D precursor, similar to steriods.
SGTC_3240 9133527 49.47 µM -1.51010387826938 0.0444299183113076 no 3156 0.0655084600321929 4471 17617455
SGTC_2416 tofa 880 nM -1.51043993346721 0.0443947193647527 no 3157 0.0654656027197014 4442 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2199 6590217 200 µM -1.51087492559002 0.0443491909816806 no 3158 0.0654101602187599 4457 703109
SGTC_977 1348-1378 135 µM -1.51120524181841 0.044314643625868 no 3159 0.0653680836565401 4478 X977
SGTC_2643 anethole 100 µM -1.52024695385821 0.0433773756464165 no 3160 0.0642244602761224 4513 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_465 cgp-37157 41 µM -1.52351243983716 0.0430428335421658 no 3161 0.0638152754214458 4554 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_672 1441-0018 53.7 µM -1.52356727407349 0.0430372337364726 no 3162 0.0638084217165377 4501 251141
SGTC_828 2074-0507 139 µM -1.52657643335565 0.0427308323602837 no 3163 0.0634331854401194 4549 X828
SGTC_2920 7982904 15.77 µM -1.52859980209641 0.0425258003063339 no 3164 0.063181842560712 4490 6456808
SGTC_1965 Pectolinarigenin 58.4 µM -1.53054672181503 0.0423292667534206 no 3165 0.062940728942401 4498 5320438 An anti-inflammatory.
SGTC_913 3487-1245 167 µM -1.53304957011962 0.0420776946536283 no 3166 0.0626318208730672 4450 4016153
SGTC_1140 3229-1848 2.98 µM -1.53402621522946 0.0419798566574292 no 3167 0.0625116018071686 4504 2849525
SGTC_3234 9132280 49.47 µM -1.53434853158294 0.0419476082146113 no 3168 0.0624719661339442 4531 17612295
SGTC_695 3505-6186 243 µM -1.53482545793338 0.0418999275062525 no 3169 0.0624133538126906 4508 1819379
SGTC_2956 9076196 2.52 µM -1.53682294266705 0.0417007055372199 no 3170 0.062168336777268 4508 16423868
SGTC_755 1995-0008 37.3 µM -1.53881928207606 0.0415023650642017 no 3171 0.0619242105799714 4483 689533
SGTC_1015 4130-4525 82 µM -1.54219603382933 0.041168618232149 no 3172 0.0615129817992404 4531 1363237
SGTC_2720 fluspirilene 36.88 µM -1.54712799818049 0.0406850729102607 no 3173 0.060916191892861 4504 3396 An atypical antipsychotic.
SGTC_1174 0739-0097 51.1 µM -1.54899791948531 0.040502949275402 no 3174 0.0606911101058507 4541 728447
SGTC_2908 7930301 100 µM -1.55011314422202 0.0403946458295736 no 3175 0.0605571808676387 4487 2223178
SGTC_3246 9135460 32.98 µM -1.55043645468941 0.0403632920047285 no 3176 0.0605183972257505 4506 41446951
SGTC_816 0325-0417 81.3 µM -1.5513890361138 0.0402710279641519 no 3177 0.0604042405405537 4557 68101
SGTC_789 1309-1135 70.6 µM -1.55563460536414 0.0398618963928624 no 3178 0.059897502477841 4507 3092424
SGTC_1723 st034307 2.5525 µM -1.55576536231212 0.039849349605531 no 3179 0.0598819487477212 4514 867466
SGTC_670 4204-0025 119 µM -1.56208861332236 0.0392464228587099 no 3180 0.059133557478711 4537 719039
SGTC_2200 6600604 21.907 µM -1.56321318342025 0.0391399758278761 no 3181 0.0590012301343762 4562 2904777
SGTC_579 4491-1009 110 µM -1.5645554915897 0.0390132264314087 no 3182 0.0588435859666199 4595 1271041
SGTC_1052 3253-3998 198 µM -1.56558968979966 0.0389157988672456 no 3183 0.058722352622363 4483 5450317
SGTC_1917 st066507 28.5 µM -1.56875786779828 0.0386185704271252 no 3184 0.0583521845370718 4479 3156428
SGTC_1966 st070145 16.1 µM -1.57069944608776 0.038437333657974 no 3185 0.0581262389644577 4504 3748532
SGTC_804 1595-0054 20.9 µM -1.57186923276048 0.038328474924368 no 3186 0.0579904406242055 4525 761523 Stimulates phospholipase C.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.57635751299068 0.0379131318398704 no 3187 0.0574717170458109 4504 16623 A steroid.
SGTC_2997 9067075 71.4286 µM -1.57997471841237 0.0375810764891969 no 3188 0.0570563281587138 4496 27209819
SGTC_3289 9119912 71.43 µM -1.58410481719229 0.0372048455945706 no 3189 0.0565849341764281 4536 17014829
SGTC_2543 pimpinellin 60.67 µM -1.59047302454732 0.0366307705383526 no 3190 0.055864110708299 4409 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_926 2268-1401 59.4 µM -1.60022656967429 0.0357655832341309 no 3191 0.0547741649570292 4516 2931578
SGTC_347 4534-1311 26.2 µM -1.60083021952762 0.0357125915033096 no 3192 0.0547072642031142 4567 2862016
SGTC_2010 4012422 159 µM -1.60357723044387 0.0354722557288907 no 3193 0.0544036365178505 4502 952393
SGTC_2369 9071472 200 µM -1.60734154209178 0.0351450717551283 no 3194 0.0539897330521587 4562 17296037
SGTC_2108 5365811 200 µM -1.60844683217511 0.0350494744941909 no 3195 0.053868675897414 4544 780283
SGTC_730 1436-0052 41.2 µM -1.60936697531733 0.0349700535740656 no 3196 0.0537680610276323 4583 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2929 9013348 24.6 µM -1.61381975806273 0.0345878019359145 no 3197 0.053283263801866 4519 2995952
SGTC_2390 9097792 176.6 µM -1.61516060609277 0.0344733707384889 no 3198 0.0531379595454481 4569 4497149
SGTC_90 0870-0863 4.608 µM -1.61694666898063 0.034321427127181 no 3199 0.0529448966587401 4569 1738164
SGTC_2341 7987486 176.74 µM -1.61714336830481 0.0343047272555754 no 3200 0.052923668671522 4552 1258686
SGTC_1087 pterostilbene 9.05 µM -1.61785600904901 0.0342442796167458 no 3201 0.0528468163015906 4550 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3138 9097216 49.47 µM -1.62157170361326 0.0339305235806796 no 3202 0.0524475427342765 4482 25237486
SGTC_1188 1403-0014 4.57 µM -1.62222517429574 0.0338755892635723 no 3203 0.0523775716627716 4586 9614867
SGTC_1493 4348-0038 111 µM -1.62356280247753 0.0337633690729273 no 3204 0.0522345748343908 4545 800424
SGTC_2881 9058953 51.95 µM -1.62461216071862 0.0336755475150863 no 3205 0.0521226121629177 4522 17122249
SGTC_2630 antimycin a 100 µM -1.62571038274588 0.0335838379165811 no 3206 0.0520056401404554 4483 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2635 hydroquinidine 100 µM -1.63275756239135 0.0330002270335227 no 3207 0.0512599978461207 4491 442912 An experimental heart treatment.
SGTC_2223 6903751 107.57 µM -1.6493223937376 0.0316612743701513 no 3208 0.0495408021339367 4542 5598863
SGTC_1161 k007-0610 110 µM -1.66025015567185 0.0308027921492554 no 3209 0.0484320692401077 4510 5843850
SGTC_1461 k072-0203 53.8 µM -1.66130814820368 0.0307207095202613 no 3210 0.0483257871903947 4461 5418714
SGTC_1471 k673-0312 37 µM -1.66208689106494 0.0306604078046258 no 3211 0.0482476767997317 4560 24099884
SGTC_994 3910-0338 138 µM -1.66689122059076 0.0302905500848918 no 3212 0.0477680184706752 4607 3479481
SGTC_1721 st082152 9.2685 µM -1.66936979827008 0.0301011891593255 no 3213 0.0475220576191581 4514 5296051
SGTC_3033 9090887 49.47 µM -1.6774798346843 0.0294884377321277 no 3214 0.0467243447420196 4595 19325384
SGTC_107 0358-0022 2.6945 µM -1.67901956789311 0.0293732811870055 no 3215 0.0465741151021823 4598 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2444 5485484 36.41 µM -1.6882451428439 0.0286910972842953 no 3216 0.0456820904126072 4612 6790631
SGTC_2004 4023728 41.89 µM -1.6887496320936 0.0286541760202414 no 3217 0.0456337099385655 4534 360084 YDR527W RBA50
SGTC_1195 1502-0147 41.1 µM -1.6963673356478 0.0281014575772969 no 3218 0.0449081678402194 4596 817940
SGTC_1835 st008666 49.2 µM -1.69904475058574 0.0279093127128044 no 3219 0.044655376057373 4554 690455
SGTC_2137 5261020 140 µM -1.70095893907613 0.0277726127712612 no 3220 0.0444753489085835 4574 763655
SGTC_2171 5739187 198.077 µM -1.7013625165198 0.0277438629994342 no 3221 0.0444374676699065 4562 2262761
SGTC_1702 st027038 51 µM -1.70564718847005 0.0274401609687219 no 3222 0.0440368939573874 4621 5521182
SGTC_2995 9067767 71.4286 µM -1.71303910403893 0.0269227321399093 no 3223 0.0433526729075406 4575 11673567
SGTC_1181 1222-0449 220 µM -1.71873942814357 0.0265292982306566 no 3224 0.0428309146225441 4620 658318
SGTC_2582 agaric acid 100 µM -1.72561514208365 0.0260611424733755 no 3225 0.0422083366973661 4226 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2504 purpurogallin 52.29 µM -1.72634271254604 0.0260120101941629 no 3226 0.0421428877289026 4548 5281571 An antioxidant.
SGTC_2266 7929956 200 µM -1.72670682939092 0.0259874507660471 no 3227 0.0421101642639279 4564 2967153
SGTC_2962 9082311 13.18 µM -1.72759001475699 0.0259279611014518 no 3228 0.0420308771354272 4580 16459453
SGTC_1762 st045503 25.4615 µM -1.7345101294486 0.0254657680829634 no 3229 0.0414138050205915 4624 4645554
SGTC_2167 5876490 200 µM -1.7360098924977 0.0253665142937822 no 3230 0.0412810427075028 4599 686534
SGTC_973 1325-0077 65.9 µM -1.74108974879047 0.025032735755362 no 3231 0.0408339239869756 4612 2835149
SGTC_2975 9084847 53.72 µM -1.74165396271699 0.0249958915664525 no 3232 0.0407845063687093 4580 27211724
SGTC_837 0091-0265 12.5 µM -1.74785168923275 0.0245941531245795 no 3233 0.0402448560675384 4618 759367
SGTC_3216 9129716 49.47 µM -1.74877028166298 0.0245350732605249 no 3234 0.0401653678805331 4518 8056934
SGTC_2087 5276107 200 µM -1.7543123563271 0.0241811528750863 no 3235 0.0396884998367224 4614 144405
SGTC_2841 9004761 38.96 µM -1.75663437928521 0.0240341469455302 no 3236 0.0394900745556789 4552 2991039
SGTC_946 3434-1334 87.4 µM -1.75970535986641 0.0238408788711556 no 3237 0.0392288882831748 4578 4047976
SGTC_148 3253-0744 288.01 µM -1.76643880889249 0.0234216874404376 no 3238 0.0386611295067107 4507 6893655
SGTC_2161 5662504 8.5105 µM -1.76760980506998 0.0233494237470779 no 3239 0.0385630788513465 4610 2859334
SGTC_2659 sanguinarine 24.21 µM -1.77990648956184 0.0226018457515929 no 3240 0.0375456327365394 4590 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_3344 9148862 3.898 µM -1.7830607712016 0.0224133659696248 no 3241 0.0372882056644366 4654 4905352
SGTC_1399 3562-5772 25 µM -1.78552975716396 0.022266761568972 no 3242 0.037087714529633 4619 23847490
SGTC_1392 3455-1037 33.9 µM -1.78843555241842 0.0220952573583937 no 3243 0.0368528823523769 4630 981132
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.79200512606467 0.0218861033404916 no 3244 0.0365660724467155 4589 279621
SGTC_2473 5854593 8.94 µM -1.80587234417402 0.0210893685795159 no 3245 0.0354691409395537 4616 2872951
SGTC_1945 st075991 56.6 µM -1.80955011129349 0.0208822287452009 no 3246 0.0351827912114102 4610 1084980
SGTC_2961 9083290 32.55 µM -1.82502236207181 0.0200295620746542 no 3247 0.0339988274284653 4610 17741490
SGTC_1030 k029-0042 36.7 µM -1.82524525783563 0.0200174974995684 no 3248 0.0339820134768527 4619 6080581
SGTC_3024 9090631 49.47 µM -1.83646903257863 0.0194179137345372 no 3249 0.0331441590071919 4640 25236383
SGTC_2912 7964298 10.93 µM -1.84012225283999 0.0192260765424351 no 3250 0.0328751454771489 4621 2975850
SGTC_392 N-ethylmaleimide 8.33 µM -1.84156037283611 0.0191510013921034 no 3251 0.0327697409819173 4621 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_36 0335-0881 14.2 µM -1.84505340515866 0.0189696894311472 no 3252 0.0325148851448221 4558 23828853
SGTC_947 3447-0010 211 µM -1.87447397332615 0.017499694116346 no 3253 0.030432563029191 4598 748350
SGTC_2072 5231554 129 µM -1.89981815805327 0.0163124435005274 no 3254 0.0287284935848693 4709 789545
SGTC_1415 3966-0071 78.1 µM -1.90504384031615 0.016076417334438 no 3255 0.0283871862868687 4584 2893185
SGTC_1402 3909-7673 35.9 µM -1.909435705401 0.0158803211941246 no 3256 0.0281029542103467 4669 5328014
SGTC_2101 5377231 179.231 µM -1.91009442623718 0.0158510870049167 no 3257 0.0280605282673283 4686 2844213
SGTC_2476 5806916 10.51 µM -1.91491922731185 0.0156383648097269 no 3258 0.0277514026730648 4620 2870194
SGTC_2571 chrysanthemic acid 100 µM -1.9172071190526 0.015538352366529 no 3259 0.0276058120046904 4643 2743 An insecticide.
SGTC_594 1487-1584 10.8 µM -1.93014539118039 0.0149830415869744 no 3260 0.0267944128045753 4651 5013332
SGTC_2140 5586273 200 µM -1.9319352815316 0.0149075790717675 no 3261 0.0266837472001754 4662 854421
SGTC_820 1582-0060 59.9 µM -1.93376497193916 0.0148307765514317 no 3262 0.0265710156762261 4687 3848840
SGTC_232 clozapine 119 µM -1.938342763836 0.0146401096901838 no 3263 0.0262907091841378 4715 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3031 9088762 49.47 µM -1.93949981076195 0.0145922534648545 no 3264 0.0262202537742243 4658 205253
SGTC_3043 9092303 49.47 µM -1.94634314068365 0.0143119526777917 no 3265 0.0258067673535675 4667 25236084
SGTC_905 2-aminofluorene 215 µM -1.95052783899471 0.0141428434541695 no 3266 0.0255566192966254 4683 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2968 9090663 33.37 µM -1.95077766203353 0.0141328024617904 no 3267 0.0255417501076194 4621 25236811
SGTC_3231 9132313 49.47 µM -1.95608328464386 0.013921002552983 no 3268 0.0252276719484286 4661 4905967
SGTC_2853 9015042 58.44 µM -1.96285288778236 0.0136547387524694 no 3269 0.0248316351857821 4598 6457456
SGTC_59 0330-0160 1.33 µM -1.97335628957909 0.013250316301731 no 3270 0.0242274919571033 4633 4293482
SGTC_2325 6158266 200 µM -1.97845328234707 0.0130578195211308 no 3271 0.0239387969649365 4646 3623240
SGTC_3283 9109332 35.8195 µM -1.97905529892648 0.0130352437279159 no 3272 0.0239048902788392 4523 17027281
SGTC_2142 5622915 118.518 µM -1.98813551341222 0.0126988035960507 no 3273 0.0233983523151262 4690 5322196
SGTC_878 0828-0289 13.7 µM -1.9896088814604 0.0126449269763392 no 3274 0.0233170185151923 4664 745350 YLR208W SEC13
SGTC_2834 9001755 58.44 µM -2.00176202959014 0.0122080197246482 no 3275 0.022655165748303 4553 2989575
SGTC_2614 arthonioic acid 13.39 µM -2.00385595267599 0.0121340792408126 no 3276 0.0225427465473951 4570 6710684
SGTC_2710 st078562 53.7235 µM -2.00934730434256 0.0119420101971472 no 3277 0.0222501572439422 4670 17250908
SGTC_2922 7999257 32.47 µM -2.01044216857106 0.0119040324136468 no 3278 0.0221922056059427 4665 2988377
SGTC_10 0279-0212 42.575 µM -2.0217340135399 0.0115184225433435 no 3279 0.0216019189876574 4716 39851 YBR002C RER2
SGTC_2368 9071271 200 µM -2.02466180053546 0.0114202291717437 no 3280 0.0214510518130844 4679 27209959
SGTC_2667 digitoxin 100 µM -2.02614361514512 0.011370809205589 no 3281 0.0213750348594541 4690 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_770 0389-1121 67.2 µM -2.03026093242991 0.0112344669348778 no 3282 0.0211650115503768 4718 6753108
SGTC_613 3914-0030 117 µM -2.03382186385165 0.0111176973052726 no 3283 0.0209847796381004 4480 1145395
SGTC_2396 5342950 42.78 µM -2.03801846664342 0.0109814389468935 no 3284 0.0207740430548697 4655 1886677
SGTC_2000 st075254 36.4 µM -2.05805917343652 0.0103505923884514 no 3285 0.0197922267363791 4634 17234175
SGTC_633 0437-0093 97.7 µM -2.0754151296343 0.00983002497239827 no 3286 0.0189740385865056 4659 2831118
SGTC_2949 9072542 2.23 µM -2.07743573934897 0.00977093144094176 no 3287 0.0188806802358384 4658 16457352
SGTC_2964 9083345 53.42 µM -2.09965937438693 0.00914119218961673 no 3288 0.0178794078615444 4676 17741579
SGTC_1016 4226-1401 38 µM -2.10626421327548 0.00896101711682889 no 3289 0.0175907040298596 4710 2901613
SGTC_1349 flufenamic acid 69 µM -2.11857274166889 0.00863353687954295 no 3290 0.0170632956953736 4663 3371 A non-steroidal anti-inflammatory.
SGTC_1460 k062-0059 9.15 µM -2.13435364759481 0.0082290578084033 no 3291 0.0164069214291529 4592 1373085
SGTC_363 0455-0021 3.06 µM -2.15673639108215 0.00768394109743221 no 3292 0.0155131049015438 4645 4597466
SGTC_2123 5259487 200 µM -2.15746182574925 0.00766681838807082 no 3293 0.0154848492277081 4713 2173474
SGTC_168 3970-0862 530.542 µM -2.15933872220019 0.0076226730727391 no 3294 0.0154119490555764 4657 3135186
SGTC_614 0462-0418 107 µM -2.18375032754413 0.00706856109513067 no 3295 0.0144902997054988 4556 5188303
SGTC_1943 st076331 65.2 µM -2.19194459285672 0.00689069800772185 no 3296 0.0141917538195411 4701 24208415
SGTC_1266 0828-0227 32.9 µM -2.22718560614515 0.00617002370525474 no 3297 0.0129674358541656 4697 3913820
SGTC_870 0573-2213 57.6 µM -2.24089382384403 0.00590825507526214 no 3298 0.0125164767061862 4737 3916321
SGTC_706 4262-0057 46.9 µM -2.2508399400442 0.00572454032924643 no 3299 0.0121978384290865 4727 883298
SGTC_19 0279-0214 38.434 µM -2.25357272276577 0.00567495927821048 no 3300 0.0121115304772727 4771 3566274 YBR002C RER2
SGTC_55 0767-0285 6.563 µM -2.25862368324488 0.00558432204062966 no 3301 0.0119534016660583 4701 3116166
SGTC_2331 7980721 200 µM -2.25943167307874 0.00556994292961223 no 3302 0.0119282730311307 4703 2981221
SGTC_322 k048-0136 19.3 µM -2.27978575747496 0.00521840292381999 no 3303 0.0113101990635947 4755 6823282
SGTC_1879 gemcitabine 100 µM -2.27989695042875 0.005216537975188 no 3304 0.0113069004898251 4715 60750 A nucleoside analog which inhibits DNA replication.
SGTC_733 4069-0007 56.1 µM -2.28625195187528 0.00511093126617844 no 3305 0.0111197615206106 4728 5717425 YNL287W SEC21
SGTC_1737 st035557 69.7 µM -2.28648906811229 0.00510702799120114 no 3306 0.0111128314715361 4641 5716916
SGTC_160 3453-0671 289.699 µM -2.28671444739594 0.00510332038355367 no 3307 0.0111062479330504 4710 5322268
SGTC_682 0kpi-0099 17 µM -2.29749128216057 0.00492880882820474 no 3308 0.0107953799096562 4727 1714895 YML126C ERG13
SGTC_2146 5545642 200 µM -2.30610531446674 0.00479316464962607 no 3309 0.0105523742172052 4729 825326
SGTC_1531 st059297 52.4 µM -2.32215306738013 0.00454931163047661 no 3310 0.0101123475395895 4750 7566702
SGTC_1027 k015-0025 8.67 µM -2.33906040092224 0.00430443567997623 no 3311 0.00966615385856521 4720 3598955
SGTC_1947 st076332 61.6 µM -2.34854505944697 0.00417228617839083 no 3312 0.00942345932954626 4670 24208416
SGTC_2797 7859098 81.82 µM -2.37550370243344 0.00381626687794255 no 3313 0.00876250829128015 4715 972681
SGTC_2129 girgensonine 121.053 µM -2.37698963773337 0.00379745974698552 no 3314 0.00872728922962517 4725 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1771 st048882 4.1505 µM -2.43228751260472 0.00315403632321005 no 3315 0.00750189606411483 4765 4580403
SGTC_1874 staurosporine 7.6 µM -2.47513277744702 0.00272488888268707 no 3316 0.00665933250797555 4760 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3054 9094397 49.47 µM -2.52328580795861 0.00230604578372363 no 3317 0.00581319321259254 4741 2598354
SGTC_2421 5690543 90.72 µM -2.52833842706753 0.00226566346033018 no 3318 0.00573019112277556 4719 3397993
SGTC_1748 st037455 53.6035 µM -2.54935773868632 0.00210445615501708 no 3319 0.00539607660119039 4742 580690
SGTC_145 3737-0113 38.366 µM -2.56629727009451 0.00198218952701827 no 3320 0.00513953463387013 4743 6849351
SGTC_2358 9037157 4 µM -2.58256183653009 0.00187090129179679 no 3321 0.00490348929151483 4749 2388925
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -2.58455685887773 0.00185764898977413 no 3322 0.00487521130932283 4763 23847180
SGTC_165 k038-0023 64.381 µM -2.59217101397356 0.00180785124679718 no 3323 0.00476861748170048 4745 46368543
SGTC_2647 atorvastatin 60.16 µM -2.59657604172271 0.00177959911439008 no 3324 0.00470790307958888 4771 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2431 5490079 200 µM -2.59704544060382 0.00177661237609039 no 3325 0.0047014741927292 4774 5722345
SGTC_3002 9075603 71.4286 µM -2.66547847110133 0.00138693373454132 no 3326 0.00384394269906339 4757 20105405
SGTC_1574 spiramycin 23.7 µM -2.83070079963018 0.000745926138645908 yes 3327 0.00232230733465894 4765 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1792 st045773 43.6 µM -2.86718599636109 0.000647670750457097 yes 3328 0.0020706977115748 4786 2919270
SGTC_2128 5255449 168.493 µM -2.870144916607 0.000640250556099571 yes 3329 0.00205141858372038 4755 736008
SGTC_2767 sibutramine 71.45 µM -2.87032305919536 0.000639806335547209 yes 3330 0.00205026309407269 4780 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1265 0819-1001 68.8 µM -2.87856416419484 0.000619564459921719 yes 3331 0.00199745002420686 4755 3106768
SGTC_2610 ononetin 44.17 µM -2.88335747483078 0.000608064786604336 yes 3332 0.00196730326462603 4766 259632
SGTC_3351 9150312 21.596 µM -2.88842692104287 0.000596117389955756 yes 3333 0.00193586991915231 4772 4904905
SGTC_1776 st049249 45.9 µM -2.93589875824484 0.000494306966704119 yes 3334 0.00166291424290269 4792 1822314
SGTC_1459 k035-0031 35.7 µM -2.97494708125105 0.000422898215830229 yes 3335 0.00146519547401537 4726 3877128 YMR208W ERG12
SGTC_1926 methyl fluorone black 53.6 µM -3.00246450835528 0.000378459002647966 yes 3336 0.00133901599310952 4617 72721 Reacts with homocysteine.
SGTC_3044 9093193 49.47 µM -3.0669286584802 0.000290772038017173 yes 3337 0.0010813523376909 4767 25236277
SGTC_42 0133-0086 60.653 µM -3.12153197560511 0.000231706412012245 yes 3338 0.000899563544005876 4761 162923 Model of phenazepam hydroxylation.
SGTC_2056 5235370 200 µM -3.14940986592365 0.000206064376253245 yes 3339 0.000818002833461104 4761 5511916
SGTC_2906 7926292 26.41 µM -3.16337796470999 0.000194237329355241 yes 3340 0.000779748593444714 4781 2966319
SGTC_1465 k213-0056 144 µM -3.16847099944026 0.000190085077883513 yes 3341 0.000766215183324807 4768 24048857 YMR208W ERG12
SGTC_1390 3413-2614 145 µM -3.1917114543683 0.00017216925663606 yes 3342 0.000707162722228007 4790 3421432
SGTC_1254 0550-0035 264 µM -3.19288217755279 0.000171309945321426 yes 3343 0.000704302041954798 4789 15121435
SGTC_1001 4048-4355 44.4 µM -3.2186970670115 0.000153351551847007 yes 3344 0.000643872251328222 4796 21824233
SGTC_35 0133-0054 64.071 µM -3.24140863171876 0.000139025092865554 yes 3345 0.000594702775425893 4772 99677
SGTC_1729 st035615 45.989 µM -3.35188753008633 8.55302057532596e-05 yes 3346 0.00040131309206979 4790 17385451
SGTC_1355 1499-0035 1.68 µM -3.56866645529424 3.1616198246776e-05 yes 3347 0.000179401432398554 4805 1548538
SGTC_349 k015-0014 24 µM -3.60802462952719 2.62324311049137e-05 yes 3348 0.000154268603162916 4795 2196908
SGTC_2405 ticlatone 3.52 µM -3.64123158331871 2.23776908091291e-05 yes 3349 0.000135668461623247 4744 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1034 k072-0165 12.7 µM -3.64186645791382 2.23095123665804e-05 yes 3350 0.000135334239835326 4803 5835461
SGTC_2433 5607874 27.82 µM -3.76239468672844 1.23916487739821e-05 yes 3351 8.4147090998468e-05 4800 2252428
SGTC_2053 5265679 138 µM -5.71177513768809 8.09065369763693e-11 yes 3352 5.59018779052081e-09 4808 764595
SGTC_1681 tripelennamine 100 µM -5.88866152020119 2.1793166763093e-11 yes 3353 1.94667958883882e-09 4810 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_750 4073-0104 132 µM -6.03043006245946 7.40916478277825e-12 yes 3354 8.17619635250947e-10 4798 22330957
SGTC_1107 amlodipine 47 µM -6.45676613529358 2.49091933873023e-13 yes 3355 5.34819985570299e-11 4777 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2423 st077119 87.2 µM -6.76251837346659 1.90600028216756e-14 yes 3356 6.78067370474379e-12 4771 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).