SGTCid condition conc unit MET17|YLR303W.score MET17|YLR303W.strain.pval MET17|YLR303W.strain.significant MET17|YLR303W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2758 dehydroepiandrosterone 69.35 µM 6.39308227491539 8.37668170379399e-10 yes 1 8.12873627108008e-11 18 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_907 3448-6986 75.5 µM 6.05471437203335 5.6767653767073e-09 yes 2 7.03335165663809e-10 2 590582 SGTC_1743 st037606 46.3785 µM 6.00541277194004 7.44093334425929e-09 yes 3 9.54228734447228e-10 2 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1749 st037932 54.2 µM 5.6461265264531 5.02144395682812e-08 yes 4 8.20515462020126e-09 10 594497 SGTC_3123 9126162 49.47 µM 5.282709368899 3.09651953328917e-07 yes 5 6.3643617940846e-08 7 25239884 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 5.01658210596337 1.09258955524884e-06 yes 6 2.62994018473765e-07 16 23665772 A membrane-active detergent. SGTC_1253 0550-0034 176 µM 4.90726779058218 1.80226376141658e-06 yes 7 4.6176948710781e-07 8 5969915 SGTC_302 1094-0063 18.9 µM 4.87268942385692 2.10697177556688e-06 yes 8 5.50446083837665e-07 3 5440289 SGTC_165 k038-0023 64.381 µM 4.84393610106979 2.39737481172205e-06 yes 9 6.36459423285431e-07 46 46368543 SGTC_1995 st072814 61.1 µM 4.79983592479675 2.91845814549979e-06 yes 10 7.9397835893137e-07 4 5769371 SGTC_348 k064-0012 10.7 µM 4.72346663434693 4.08679914749345e-06 yes 11 1.15929006755396e-06 8 5066323 SGTC_1958 st076513 41.9 µM 4.66791697487356 5.20479314185186e-06 yes 12 1.5213439943681e-06 18 732122 YGL099W LSG1 SGTC_1909 st060837 51.5 µM 4.60863653164477 6.71782744817713e-06 yes 13 2.02659088460852e-06 34 678937 SGTC_920 mycophenolic acid 780.421 nM 4.52250801273775 9.68172899592492e-06 yes 14 3.05555862419032e-06 17 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_430 0958-0115 16.4 µM 4.42055399503963 1.48024378470375e-05 yes 15 4.92240908192343e-06 17 6833180 SGTC_2805 7950783 58.44 µM 4.37000234488918 1.82114899232399e-05 yes 16 6.21226011688961e-06 21 1178958 YDL195W SEC31 SGTC_1170 0310-0127 64.8 µM 4.35605910006247 1.92756325418971e-05 yes 17 6.62125176192507e-06 14 774975 SGTC_274 sirtinol 40.1 µM 4.34192595525072 2.04143374215383e-05 yes 18 7.06195681687216e-06 14 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_431 k089-0097 107 µM 4.19109112859963 3.72757834208e-05 yes 19 1.3880805973761e-05 33 5499420 SGTC_160 3453-0671 289.699 µM 4.14593855154152 4.44726783903107e-05 yes 20 1.69212292379501e-05 37 5322268 SGTC_2017 5132927 60.65 µM 4.13820277257001 4.58304154788745e-05 yes 21 1.75018476781037e-05 28 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2982 9019404 25.97 µM 4.10244658535045 5.26307068128339e-05 yes 22 2.04402125290635e-05 18 22333232 SGTC_2756 carbadox 75.1 µM 4.05204335304271 6.38482403168532e-05 yes 23 2.53861269570362e-05 55 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1239 0337-0584 35.4 µM 3.96983157653483 8.7103217407678e-05 yes 24 3.59617269120794e-05 51 914301 YML130C ERO1 SGTC_2938 9059746 27.26 µM 3.90723473541695 0.00010992448184411 yes 25 4.66792230720221e-05 40 6471769 SGTC_766 1391-0721 126 µM 3.87441256618513 0.00012402741546549 yes 26 5.34411040773933e-05 15 1020919 YIL115C NUP159 SGTC_756 0508-1999 28.3 µM 3.83612331568023 0.00014262003914444 yes 27 6.24958327216193e-05 33 6753853 SGTC_2773 thioridazine 9.09 µM 3.80183628005062 0.00016145552701974 yes 28 7.18138139699032e-05 12 5452 An antipsychotic. SGTC_1292 0kpi-0043 232 µM 3.77886657439987 0.000175350019055799 yes 29 7.87719025113825e-05 18 3333905 SGTC_984 1492-0255 2.91 µM 3.76142993471648 0.000186635874336637 yes 30 8.44723742106425e-05 32 1585198 SGTC_1071 trifluoperazine 6.31 µM 3.6991374423089 0.000232742766344056 yes 31 0.000108166716215818 32 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_378 3970-0959 8.33 µM 3.69694971074668 0.000234540659237882 yes 32 0.000109102773425696 21 6615653 SGTC_3041 9091929 49.47 µM 3.69322495072203 0.000237631532256931 yes 33 0.000110713992846469 26 25236887 SGTC_485 niflumic acid 177 µM 3.68865738556494 0.000241473642699638 yes 34 0.000112720277619023 14 4488 A COX2 inhibitor. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 3.68485703818967 0.000244714466045311 yes 35 0.000114415522886386 33 1377 SGTC_3196 9111891 49.47 µM 3.66685771991575 0.000260622155879967 yes 36 0.000122774664829071 28 18891510 SGTC_47 0149-0135 24.25 µM 3.66361735649197 0.000263586392315452 yes 37 0.000124339099570593 25 5239155 SGTC_1990 st072050 59.8 µM 3.61900276882053 0.00030772614017348 yes 38 0.000147870237295907 19 17233948 SGTC_2183 6420625 130.508 µM 3.58958292643292 0.00034049692943257 yes 39 0.000165603728628289 75 2897619 SGTC_1767 st044992 70.3 µM 3.58954564947985 0.000340540436730333 yes 40 0.000165627410411536 29 9600693 SGTC_2087 5276107 200 µM 3.58212053719875 0.00034931032836641 yes 41 0.00017040823149206 25 144405 SGTC_1752 st044819 83.042 µM 3.56463955193291 0.000370792728832498 yes 42 0.000182178277770371 34 441209 YML126C ERG13 SGTC_1205 4161-2785 76 µM 3.56172007401677 0.000374497864033033 yes 43 0.000184216545946894 44 3498106 SGTC_571 k831-0106 44.2 µM 3.54232705528595 0.00039999582475067 yes 44 0.000198306699396769 21 4783639 SGTC_1671 st016596 74.5 µM 3.53093085033984 0.000415721723955039 yes 45 0.000207049995465217 22 2829167 SGTC_2596 sinensetin 100 µM 3.49277831191641 0.000472640160005216 yes 46 0.000239011588190544 50 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3159 9100096 49.47 µM 3.47932666865804 0.000494372686952401 yes 47 0.000251337714737038 36 25236875 SGTC_2067 5224629 34.075 µM 3.44499571409099 0.000554100980930492 yes 48 0.000285534223222277 38 2835000 SGTC_404 fumagillin 50 µM 3.40310550830574 0.000636002429753237 yes 49 0.00033312273636828 40 12015870 A methionine aminopeptidase binder. SGTC_654 1124-0271 80.9 µM 3.37892877328683 0.000688219161498965 yes 50 0.000363844293929867 49 5403748 SGTC_3000 9075062 71.4286 µM 3.32956987349322 0.000807308414977026 yes 51 0.000434901184264897 41 17057871 SGTC_1696 st025591 34.7925 µM 3.27810595867058 0.000951442292341729 yes 52 0.000522530794688755 48 2787147 SGTC_1913 st060213 96.1 µM 3.27273707013876 0.000967766998251834 yes 53 0.000532557542378962 65 688959 SGTC_3122 9126309 49.47 µM 3.25904468610341 0.00101057138364334 no 54 0.000558940292890592 24 17591206 SGTC_970 1315-0089 19.5 µM 3.25765884991344 0.00101499915015639 no 55 0.000561676829468063 49 6811083 YLR033W RSC58 SGTC_3247 9135149 49.47 µM 3.21699520776318 0.00115311630260077 no 56 0.000647703812441999 36 8934436 YOR116C RPO31 SGTC_2091 4-phenylthiadiazole 200 µM 3.202375997257 0.00120683860667613 no 57 0.000681494836184055 37 270010 SGTC_1571 st070080 73.4 µM 3.19212876442903 0.00124585015026047 no 58 0.00070614179216583 44 4315245 SGTC_2776 terbinafine 19.92 µM 3.19032757982775 0.00125282536407175 no 59 0.000710558055434574 92 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_820 1582-0060 59.9 µM 3.17676698815147 0.00130649755306902 no 60 0.000744633192420907 70 3848840 SGTC_1144 3486-0183 12.5 µM 3.17042480898161 0.00133231409559741 no 61 0.000761081110570298 51 6744069 SGTC_579 4491-1009 110 µM 3.13303953234066 0.00149420361938961 no 62 0.000865030694760206 57 1271041 SGTC_409 arachidonic acid 100 µM 3.11131951974717 0.00159630766736795 no 63 0.00093126643965165 37 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1293 1000-1278 195 µM 3.10173321272076 0.00164336259021389 no 64 0.000961956307587088 47 678847 SGTC_1073 triclabendazole 3.09 µM 3.09228310307347 0.00169098232646625 no 65 0.000993116621454969 80 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2031 5180455 200 µM 3.07099765279608 0.001802875682048 no 66 0.00106672414021349 41 29949 SGTC_853 0419-0306 21 µM 3.06321062117226 0.00184546487174821 no 67 0.00109487939001454 45 762713 SGTC_1526 st051518 75 µM 3.05570457584373 0.00188738102009932 no 68 0.00112266184519324 51 673993 SGTC_2865 9030313 51.95 µM 3.04571676361426 0.00194449769247433 no 69 0.00116063194680262 47 42562754 SGTC_1663 st014140 55.4 µM 3.03812639543139 0.0019889493517534 no 70 0.00119027041768471 50 4207120 SGTC_2701 st077767 14.721 µM 3.022614819478 0.00208267173331019 no 71 0.00125300496903684 95 5721188 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 3.01024485550319 0.00216026435042592 no 72 0.00130518579831544 56 688669 SGTC_1677 st019204 53.9 µM 3.00037706489143 0.00222403087169049 no 73 0.00134822788203963 67 3945625 SGTC_1816 st051957 91.6 µM 2.97399122078785 0.00240300255128537 no 74 0.00146976742645691 37 674121 SGTC_2714 st079313 56.9 µM 2.93646022557609 0.00268004809190366 no 75 0.00165990695045826 52 2939799 SGTC_1747 st037496 66.6 µM 2.93472586866972 0.00269352161232813 no 76 0.00166921240852501 72 723305 SGTC_2761 levamisole 97.89 µM 2.93291303539173 0.00270767013049907 no 77 0.00167898968012143 56 26879 An alkaline phosphatase inhibitor. SGTC_285 1486-1325 46 µM 2.92075033177717 0.00280434373479238 no 78 0.00174594769095721 59 22310230 SGTC_1910 st062352 60.4 µM 2.90828876571924 0.00290661212384602 no 79 0.00181706297857549 92 2245730 SGTC_2173 5763948 167 µM 2.85139576166773 0.00341753482372601 no 80 0.00217638776803508 58 2867177 SGTC_2485 5633444 17.78 µM 2.84390969362482 0.0034904534801042 no 81 0.0022281838244821 103 5724239 SGTC_223 busulfan 5 mM 2.83860904767183 0.00354292668649422 no 82 0.00226553171051946 38 2478 A DNA alkylator. SGTC_20 0481-0013 4.944 µM 2.82863315811933 0.00364360640690637 no 83 0.00233736246740414 86 182045 SGTC_888 0916-0002 6.97 µM 2.81803283821959 0.0037533944498724 no 84 0.00241594338999312 94 2802138 YIL048W NEO1 SGTC_1121 fusaric acid 630.51 nM 2.81765187541749 0.00375739474595774 no 85 0.00241881147761235 97 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3151 9099821 49.47 µM 2.81622844636787 0.0037723752980701 no 86 0.00242955507709751 77 17174189 SGTC_496 calpeptin 138 µM 2.80372278745183 0.00390630768556334 no 87 0.00252581590384999 71 73364 A calpain inhibitor. SGTC_911 3456-4043 236 µM 2.80178250474411 0.00392746510181867 no 88 0.00254105615929521 102 914281 SGTC_3268 9137683 49.47 µM 2.80162868927038 0.0039291467346218 no 89 0.00254226787586727 42 1953228 SGTC_2855 9016525 58.44 µM 2.77413589605546 0.0042402844409178 no 90 0.00276742761012161 88 43811474 SGTC_773 4358-1457 44.6 µM 2.76689569803177 0.00432580509593058 no 91 0.00282964291280403 119 1186886 SGTC_1855 st056195 39.6 µM 2.75542264897563 0.00446448365615151 no 92 0.00293081812714306 80 4028379 SGTC_120 rhodamine 6G 52.259 µM 2.72632359604676 0.00483418101727568 no 93 0.00320220880068757 118 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2908 7930301 100 µM 2.72082088588956 0.00490708348174688 no 94 0.00325600176553653 112 2223178 SGTC_1464 k208-0027 110 µM 2.70758997897255 0.00508639722798874 no 95 0.00338868480824402 85 X1464 SGTC_1876 myriocin 605 nM 2.70212824168748 0.00516210356176968 no 96 0.00344485915090367 95 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1934 st074720 32.6 µM 2.69220748832839 0.00530218604628616 no 97 0.00354903851759078 137 17250992 SGTC_755 1995-0008 37.3 µM 2.6591014128864 0.00579442848399887 no 98 0.00391746877292766 81 689533 SGTC_989 1501-0895 10.3 µM 2.63611316706398 0.00615968134279143 no 99 0.00419308789573004 56 2830112 SGTC_1574 spiramycin 23.7 µM 2.6314482014695 0.00623624336515236 no 100 0.00425109133123019 107 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2974 9094440 9.66 µM 2.62852110846382 0.00628471237972073 no 101 0.00428785165104996 135 25236134 SGTC_559 1550-0661 158 µM 2.62497206145572 0.00634392732062799 no 102 0.00433280387115953 70 5830875 SGTC_124 0136-0217 7.121 µM 2.62425664244224 0.00635592353678401 no 103 0.00434191621306546 141 3976905 SGTC_1863 st057641 20.1 µM 2.61868679330098 0.00645000799877396 no 104 0.00441344752778063 86 3921635 SGTC_2815 7968870 71.43 µM 2.6153750433377 0.0065065314966015 no 105 0.00445647637448666 120 2977326 YHR190W ERG9 SGTC_433 pimozide 108 µM 2.61392847794659 0.00653135801930809 no 106 0.00447538857778341 70 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_930 2810-3379 265 µM 2.59720913504589 0.00682444009825404 no 107 0.00469923407610142 91 1015764 SGTC_612 0302-0167 22.4 µM 2.58235334414523 0.00709453972391245 no 108 0.00490645293788266 140 235821 SGTC_1969 st069479 40.1 µM 2.58223272399878 0.00709677083455363 no 109 0.00490816823984336 74 3895485 SGTC_3077 9117319 49.47 µM 2.57476720141589 0.00723607115208329 no 110 0.00501537874797199 77 17154678 SGTC_969 1313-0238 134 µM 2.53451500902515 0.00802947204594432 no 111 0.00563015515838927 136 5212874 SGTC_764 1951-2361 146 µM 2.52729083112823 0.00817969058005927 no 112 0.00574731359130537 127 5438930 SGTC_2483 5729050 27.16 µM 2.50296130175491 0.00870390822392537 no 113 0.00615795047976731 141 2865180 SGTC_530 4358-1714 28 µM 2.50089423869457 0.00874977514930906 no 114 0.00619400835117427 154 1564641 SGTC_966 1300-0360 30.2 µM 2.47647124623868 0.0093079606413016 no 115 0.00663441562523173 126 70588 SGTC_2274 7947094 46.08 µM 2.47427068873595 0.00935975191251185 no 116 0.00667542488157089 140 2971028 SGTC_943 3253-1379 105 µM 2.47160443997985 0.00942284109643467 no 117 0.00672541276709946 118 668464 SGTC_872 0588-0139 234 µM 2.47031807784974 0.0094534119769132 no 118 0.006749648073367 147 2047100 SGTC_2653 dihydrofissinolide 100 µM 2.46963660251285 0.00946964261433431 no 119 0.00676251844112501 65 6857746 SGTC_73 0327-0325 16.231 µM 2.46905889055669 0.00948342100832853 no 120 0.00677344610768293 198 53298 SGTC_3130 9127414 49.47 µM 2.46375007167278 0.00961085889557534 no 121 0.00687459732121107 89 1494646 SGTC_2751 anetholtrithion 17.25 µM 2.45656994579662 0.00978559721136203 no 122 0.00701352463567453 139 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 2.44205816702764 0.0101472514300136 no 123 0.00730189671422176 140 521171 SGTC_1364 1653-0028 37.6 µM 2.4279154507688 0.010510872806837 no 124 0.00759294150760541 134 5718652 SGTC_121 0557-0495 61.343 µM 2.4265052460956 0.0105477454136716 no 125 0.00762251495660317 223 3104427 SGTC_1919 st067113 52.3 µM 2.42354077378794 0.0106256250681737 no 126 0.00768501387659016 146 1268243 SGTC_1672 st016598 6.51 µM 2.41952134098564 0.010732019260715 no 127 0.00777047439426202 199 4665860 YNL267W PIK1 SGTC_2943 9068529 45.32 µM 2.41296120960305 0.0109076584119718 no 128 0.00791175176151404 143 3270634 SGTC_3003 9075612 71.4286 µM 2.40750201501501 0.0110557230886266 no 129 0.00803103678358802 125 6501993 SGTC_877 0771-0151 33.1 µM 2.40585567861374 0.011100716881174 no 130 0.00806731865504063 118 6166523 SGTC_1017 4239-0030 168 µM 2.38881230155534 0.0115759426343163 no 131 0.00845146775429951 155 1149593 SGTC_883 0850-0245 24.6 µM 2.38114413388993 0.0117954557861732 no 132 0.00862947875904665 142 6823229 YPR165W RHO1 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 2.36460947220711 0.0122811090146857 no 133 0.00902454609352759 134 16486 A toxic proline analog. SGTC_3115 9123671 49.47 µM 2.36177656134767 0.0123660323859937 no 134 0.00909380019822053 80 3286988 SGTC_1787 fluconazole 80 µM 2.36026431901781 0.0124115734113056 no 135 0.00913095904792169 197 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1448 4255-0083 152 µM 2.35616179101347 0.0125358528882669 no 136 0.0092324367315047 131 5399660 SGTC_3302 9125395 16.351 µM 2.355846562087 0.0125454466584428 no 137 0.00924027472422695 122 17599668 SGTC_787 4152-0075 138 µM 2.34445848815507 0.0128963234583485 no 138 0.00952736577148984 126 9566539 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 2.33462148445824 0.0132062104801732 no 139 0.00978160159387529 86 5357218 A potent inhibitor of glutathione S-transferases. SGTC_307 1501-1223 22.3 µM 2.33340852457014 0.0132448633528188 no 140 0.00981335714532451 114 2830329 SGTC_1035 k081-0041 55.2 µM 2.3083934443757 0.0140640800330197 no 141 0.0104886316432806 153 731709 SGTC_2025 5147754 141 µM 2.29279703697859 0.014596647687791 no 142 0.0109298463477131 102 315777 YLR208W SEC13 SGTC_2030 5175110 200 µM 2.29199745464982 0.0146244123753888 no 143 0.0109528950280619 153 2831986 SGTC_234 nsc-17383 10.7 µM 2.28061437133753 0.0150246336767357 no 144 0.0112856380670179 163 408974 SGTC_122 0236-0016 402.397 µM 2.27726219790733 0.0151442735370804 no 145 0.0113852864457883 210 6808838 SGTC_289 k017-0060 526 µM 2.27717287005729 0.0151474728339206 no 146 0.0113879522743906 102 5512909 SGTC_45 0kpi-0036 14.9 µM 2.27320170514076 0.0152902889236404 no 147 0.0115070137992083 142 2795021 SGTC_332 4112-0506 40.9 µM 2.26738078897661 0.0155017173312182 no 148 0.0116834870132948 140 2790355 SGTC_2529 gangaleoidin 93.61 µM 2.26476225094124 0.0155976437173511 no 149 0.0117636365437443 119 4565183 SGTC_2464 5717415 7.67 µM 2.26468768588501 0.0156003827437702 no 150 0.0117659258386273 153 5285744 SGTC_1274 0865-0114 173 µM 2.25464530075111 0.0159730643508382 no 151 0.0120778007924221 157 870624 SGTC_1297 1068-0111 14.1 µM 2.25062878239197 0.0161242435138805 no 152 0.0122045294329246 139 767057 SGTC_2095 5432005 200 µM 2.24329063139994 0.0164036142965304 no 153 0.012439039559413 128 783734 SGTC_3120 9124077 49.47 µM 2.2375789658054 0.0166239220087799 no 154 0.0126242622520375 120 18774327 YGL155W CDC43 SGTC_855 0428-0020 25 µM 2.23641191587356 0.0166692471105237 no 155 0.0126624006582214 135 6812414 SGTC_523 1934-0222 13.7 µM 2.23249646310448 0.0168220860994241 no 156 0.0127910843647795 176 1361595 SGTC_2499 avocadenofuran 51.48 µM 2.22994963651736 0.0169221430618906 no 157 0.0128753932939289 191 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2361 9034121 116 µM 2.2279322911088 0.017001759109049 no 158 0.0129425152363694 144 6496917 SGTC_1923 st058458 19.1 µM 2.22527016668964 0.017107311766243 no 159 0.0130315534688606 215 3534982 SGTC_784 4579-0127 173 µM 2.21332622648196 0.0175878063039332 no 160 0.0134375813740105 161 1948547 SGTC_142 0335-0849 62.6745 µM 2.21325851236619 0.0175905628912418 no 161 0.0134399140697632 324 3889043 YPR107C YTH1 SGTC_2037 5169046 200 µM 2.20901677239617 0.0177639773543517 no 162 0.0135867371579011 134 5718022 SGTC_1775 st081588 35.1725 µM 2.2070710576316 0.0178440104375208 no 163 0.0136545477080364 181 1426443 YGL099W LSG1 SGTC_857 0438-0306 1.35 µM 2.1958426459144 0.0183119019276558 no 164 0.0140516040314108 137 4686136 SGTC_1008 4106-0037 6 µM 2.18219749301709 0.0188945316413096 no 165 0.0145474801274134 142 2905394 SGTC_1400 3771-8998 51.5 µM 2.16649367967754 0.0195845093198613 no 166 0.0151367411546647 110 670767 SGTC_1279 0874-0590 65.2 µM 2.1607014395192 0.0198443484524395 no 167 0.0153592048252024 187 3523074 SGTC_2506 ethyl hematommate 54.16 µM 2.16047850900737 0.019854407278545 no 168 0.0153678227737831 149 3940691 An allergen. SGTC_678 1218-2179 85.9 µM 2.15158358576808 0.0202592996451024 no 169 0.0157150830332907 91 6820081 YOR116C RPO31 SGTC_2948 9070189 9.45 µM 2.14838049606152 0.0204068068948858 no 170 0.0158417704521178 180 6473636 YDL196W YDL196W SGTC_1208 2323-2347 50.3 µM 2.14584675943268 0.0205241332374519 no 171 0.0159426033215149 153 5412760 SGTC_1224 0823-0416 294 µM 2.13850835703089 0.020867172160741 no 172 0.0162377532961412 170 3598164 SGTC_3192 9110362 49.47 µM 2.13380150899715 0.0210897423460771 no 173 0.0164295161673111 152 16649480 SGTC_1839 st053978 48 µM 2.12820849266657 0.0213568245052783 no 174 0.0166599005032769 183 3788398 SGTC_782 0083-0095 30.5 µM 2.12583941429878 0.0214708138586211 no 175 0.0167583164770287 218 3591729 An indicator and reagent. SGTC_1806 st050005 60.3 µM 2.12405192543418 0.0215571597790885 no 176 0.0168329009187774 188 5194765 SGTC_2850 9015429 58.44 µM 2.12404084209409 0.0215576960818256 no 177 0.0168333642644246 179 6457570 SGTC_2664 lyso-paf C-16 73.48 µM 2.11090236445819 0.0222014223154036 no 178 0.0173903524091382 191 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2814 7977482 42.97 µM 2.10683290249936 0.0224040683781204 no 179 0.0175660331842893 260 6456762 SGTC_560 2332-1943 155 µM 2.09724317208755 0.0228877830246012 no 180 0.0179860272856875 149 21177716 SGTC_2510 benzyl isothiocyanate 8.31 µM 2.09489730433864 0.0230074410473366 no 181 0.0180900612762174 170 2346 DNA damaging agent; causes G2/M arrest. SGTC_2163 5671233 125 µM 2.08666561976262 0.0234314990394783 no 182 0.0184591855542837 212 701023 SGTC_3343 9148379 18.9835 µM 2.07962370872871 0.0237994666406486 no 183 0.018780030312438 165 1955036 SGTC_1362 1611-0397 101 µM 2.07936483477459 0.0238130858810233 no 184 0.0187919150443366 193 27816 SGTC_1283 0922-0125 16.4 µM 2.07847271204329 0.0238600702538139 no 185 0.0188329208499906 192 3360884 SGTC_1842 st055362 61.2 µM 2.07735991267514 0.0239187859376968 no 186 0.0188841765899111 215 676032 SGTC_123 0083-0120 66.675 µM 2.07330621837953 0.024133702736036 no 187 0.0190718951800959 226 16001701 SGTC_906 1165-0455 526 µM 2.07057679622457 0.0242793218852656 no 188 0.0191991812261667 150 3252859 SGTC_3166 9102297 49.47 µM 2.07028323354083 0.0242950277917902 no 189 0.0192129143737901 226 25237072 SGTC_1737 st035557 69.7 µM 2.04894434131311 0.0254597483725499 no 190 0.0202337788885468 178 5716916 SGTC_1848 st056003 16.4 µM 2.02782455214506 0.0266581976400964 no 191 0.021289078798196 201 146492 SGTC_191 3914-0123 66.505 µM 2.0180001904832 0.0272315393566034 no 192 0.021795620743841 95 3144412 SGTC_3165 9101544 49.47 µM 2.01762395099649 0.0272536993318914 no 193 0.0218152202541537 195 5002184 SGTC_1411 3909-8223 150 µM 2.01516814067216 0.0273987129251561 no 194 0.0219435172411336 196 X1411 SGTC_2992 9074591 71.4286 µM 2.01450898079778 0.0274377451256543 no 195 0.0219780614671234 175 17741321 SGTC_1036 k216-0215 33.5 µM 2.01160475279891 0.0276102717934394 no 196 0.0221308090005158 274 622330 SGTC_17 0960-0276 49.807 µM 2.01019995685003 0.027694048108453 no 197 0.0222050149935716 261 6821114 SGTC_1633 st005664 67.9 µM 2.00905543925609 0.0277624589879025 no 198 0.0222656273274748 249 2063822 SGTC_2110 5483698 200 µM 2.00623276426872 0.0279317798957862 no 199 0.0224157098577505 205 2848765 YHR062C RPP1 SGTC_3258 9138477 49.47 µM 1.99796482533295 0.0284326966421249 no 200 0.0228602368502374 194 4970355 SGTC_2028 5153890 36.43 µM 1.99686882677281 0.0284996558624674 no 201 0.0229197171869012 224 2830968 YPR165W RHO1 SGTC_1386 3228-0095 33.8 µM 1.99400798566592 0.0286750551806185 no 202 0.0230755909113846 199 870181 SGTC_1075 aripiprazole 15.2 µM 1.99347172049092 0.0287080335197746 no 203 0.0231049085979156 264 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2232 chlorophetanol 41.5365 µM 1.98886829251854 0.0289924268353028 no 204 0.023357871185731 359 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2404 5161160 200 µM 1.98635423217407 0.0291487278935557 no 205 0.023497002385471 250 2831543 SGTC_1530 rhein 70.4 µM 1.97344237551349 0.029962536742607 no 206 0.0242225918599145 217 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1664 st014217 9.02 µM 1.97277180630488 0.0300053110213082 no 207 0.0242607833470799 221 3982782 SGTC_1155 4088-0394 48.2 µM 1.96667164968177 0.0303967582180936 no 208 0.0246105386637563 229 2326248 SGTC_1802 st050112 57.9 µM 1.9625732154508 0.0306621239285272 no 209 0.0248478927597101 212 4662563 SGTC_641 4092-0595 30 µM 1.95573761930508 0.0311089821409181 no 210 0.0252480353594045 233 786260 SGTC_1722 st034304 3.6505 µM 1.94672095553513 0.0317066490601031 no 211 0.0257840989454803 260 4036148 YLR033W RSC58 SGTC_1234 0326-0494 15.5 µM 1.94025116026385 0.032141318311301 no 212 0.0261745868623037 210 1547813 SGTC_2725 haloperidol 53.21 µM 1.93361019262425 0.0325925920720282 no 213 0.0265805365627257 267 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_589 1227-0070 34.1 µM 1.92727456619866 0.0330279752628377 no 214 0.0269727107545886 229 2841384 SGTC_1759 st043059 70 µM 1.926280621845 0.0330967119022215 no 215 0.0270346718598002 244 669426 SGTC_3179 9107801 49.47 µM 1.92508427730421 0.033179601873197 no 216 0.0271094078035128 220 4818259 SGTC_1821 st053465 65.6 µM 1.92177139265151 0.0334100313478022 no 217 0.0273172647255629 194 675086 SGTC_2849 9019321 12.99 µM 1.92053312561643 0.0334964972769656 no 218 0.0273952965513265 262 16489627 SGTC_1042 0350-0096 82 µM 1.92049877981097 0.0334988982051684 no 219 0.0273974635662384 252 3122515 SGTC_427 1354-0053 47.3 µM 1.91988349211233 0.0335419336244635 no 220 0.0274363087644477 260 6813657 SGTC_2281 7943571 200 µM 1.91696005369247 0.033747031593799 no 221 0.0276215033554356 229 1244024 SGTC_190 3970-0790 3.722 µM 1.91598015273047 0.0338160084118942 no 222 0.0276838110080312 210 2832352 SGTC_3319 9138450 16.7555 µM 1.91432435379453 0.0339328263436758 no 223 0.0277893622569854 222 2029690 SGTC_2904 7225135 42.03 µM 1.91235265562142 0.0340723639527996 no 224 0.0279154881107986 214 4446116 SGTC_459 nigericin 15.3 µM 1.91185421914944 0.0341077130497639 no 225 0.0279474475591317 301 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1021 4476-0760 85.3 µM 1.90540260385093 0.0345679884125985 no 226 0.0283638785068347 268 746768 SGTC_3053 9095903 49.47 µM 1.90259595048622 0.0347698090001966 no 227 0.0285466439837153 186 17174018 SGTC_689 0833-0039 98 µM 1.89968102737974 0.034980438221889 no 228 0.0287374958074831 246 5374726 SGTC_178 4092-0806 87.505 µM 1.89411906562097 0.0353852450323377 no 229 0.0291046038072136 393 2169044 SGTC_478 N-arachidonylglycine 10 µM 1.88809780765307 0.035827802497414 no 230 0.0295064105687421 125 5283389 SGTC_189 3970-0742 2.116 µM 1.88130158690686 0.03633275665287 no 231 0.0299654526416328 193 2891807 SGTC_2502 avocadyne acetate 18.59 µM 1.87178815321237 0.0370493673936792 no 232 0.0306179589468458 312 3952079 SGTC_72 0744-0168 198.391 µM 1.86891828228434 0.0372677981213756 no 233 0.0308170921731171 260 677577 SGTC_821 1114-0266 29.2 µM 1.86512971302863 0.0375577626090914 no 234 0.0310816123076035 244 3123235 SGTC_1409 3909-8004 61.9 µM 1.86182458095701 0.0378122285660404 no 235 0.0313139102462725 295 2119279 SGTC_2575 plumbagin 510 nM 1.85197124740664 0.0385792086734044 no 236 0.0320149759046814 285 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2793 7325131 81.82 µM 1.84815404372151 0.0388797250603498 no 237 0.0322900307335194 231 4176441 SGTC_752 1896-0090 130 µM 1.84455898710662 0.0391644931081643 no 238 0.0325508588391822 262 772567 SGTC_119 0121-0043 24.815 µM 1.84305124868641 0.0392844268079465 no 239 0.0326607641418105 475 1092378 SGTC_14 0354-0009 295 µM 1.8421144058987 0.0393590988008868 no 240 0.0327292085120634 267 1713507 SGTC_677 0929-0063 136 µM 1.84027754305405 0.0395058429877748 no 241 0.0328637503097628 195 1539583 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.83623601296857 0.0398302816719878 no 242 0.0331613793049735 199 15053 SGTC_305 1682-2595 20.8 µM 1.83270484133219 0.0401155205841485 no 243 0.033423238470953 264 226033 SGTC_631 k072-0230 41.5 µM 1.82690552670946 0.0405875733142845 no 244 0.0338569875780562 286 5773147 SGTC_563 tetrahydrosecaminediol 614 µM 1.8240414806638 0.0408223587570324 no 245 0.0340729006998733 293 334274 A psychoactive constituent of the cannabis plant. SGTC_1047 2043-3044 82 µM 1.81331602167907 0.0417114052938054 no 246 0.0348915467899365 300 669592 SGTC_1785 bathophenanthroline 24 µM 1.81027460032878 0.0419663468710187 no 247 0.0351266069441241 323 72812 An iron chelator. SGTC_2903 5923464 63.88 µM 1.80912911177924 0.0420626917668145 no 248 0.0352154736618011 222 2876576 SGTC_3121 9125696 49.47 µM 1.80647754114559 0.0422863973203603 no 249 0.0354218895757327 213 1235365 SGTC_1965 Pectolinarigenin 58.4 µM 1.80595920907569 0.0423302398124869 no 250 0.0354623556997988 255 5320438 An anti-inflammatory. SGTC_2818 7996756 12.99 µM 1.80363651140924 0.04252715418988 no 251 0.0356441541928117 194 2241621 SGTC_3134 9127454 49.47 µM 1.8018998777361 0.0426748665032076 no 252 0.0357805797388516 238 24262820 SGTC_1197 1601-0112 267 µM 1.79982585310973 0.0428518193647126 no 253 0.035944070192535 314 7350313 SGTC_2440 5628896 157.78 µM 1.79730629367605 0.0430675818744396 no 254 0.0361435038097295 265 5522048 SGTC_2388 9080168 200 µM 1.7966932114772 0.0431202157179807 no 255 0.0361921686335688 224 15943073 SGTC_1573 oleylamine 1.06 µM 1.78270152962497 0.0443356061075903 no 256 0.0373174511130278 319 5356789 An amine of the fatty acid oleic acid. SGTC_595 3909-8003 73.7 µM 1.78211446309727 0.044387199175662 no 257 0.0373652838612326 293 699517 SGTC_2153 5569715 200 µM 1.77536868763877 0.044983515591784 no 258 0.0379185153413571 247 2054701 SGTC_86 0417-1630 471.922 µM 1.77471563216572 0.0450415854473683 no 259 0.0379724264334544 464 3634867 SGTC_871 0574-0004 149 µM 1.76748908282667 0.0456882078308088 no 260 0.0385731778709152 335 9551173 SGTC_2979 9012552 45.46 µM 1.75777331643792 0.0465692995049738 no 261 0.0393930436364652 231 17100905 SGTC_147 4466-0538 29.23 µM 1.75763248827833 0.0465821703147663 no 262 0.0394050308691788 329 6742687 YHR072W ERG7 SGTC_2673 kobusone 100 µM 1.75675550608928 0.0466623852344588 no 263 0.0394797460163563 213 6710676 An epoxy ketone and protein crosslinker. SGTC_1199 1638-0010 4.46 µM 1.75367466005086 0.0469450598882674 no 264 0.0397431349623563 339 3111136 SGTC_1547 harmine 94.2 µM 1.75192232517599 0.0471064522886551 no 265 0.0398935825616246 381 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3103 9120822 49.47 µM 1.74859865419555 0.0474137886733852 no 266 0.0401802095544052 301 17141819 SGTC_730 1436-0052 41.2 µM 1.7481699905492 0.0474535434572247 no 267 0.0402172981743843 245 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_306 1672-3436 11.6 µM 1.74678481670673 0.047582188758277 no 268 0.040337335641697 297 6797378 SGTC_2276 7947513 42.08 µM 1.74439429439057 0.0478048607507509 no 269 0.0405451796148996 286 2105100 SGTC_1318 1280-3875 124 µM 1.74199623736232 0.0480290720909259 no 270 0.0407545513281821 352 373245 SGTC_3028 9087778 49.47 µM 1.74002054475848 0.0482144252337056 no 271 0.0409277052619807 274 17217395 SGTC_2836 9010338 19.48 µM 1.73765699384904 0.0484369173623435 no 272 0.0411356354096631 314 2994051 SGTC_340 k038-0059 454 µM 1.72780458506075 0.0493732296783923 no 273 0.0420116325464011 335 23733424 SGTC_1263 0774-1208 64.8 µM 1.7253195444616 0.0496116602496345 no 274 0.042234950815774 387 906585 SGTC_2213 7173844 200 µM 1.72365770506108 0.0497716197140335 no 275 0.0423848273014346 299 892728 SGTC_1757 st041620 31.8375 µM 1.72165996938204 0.0499644549881188 no 276 0.0425655664307144 324 5289815 SGTC_2455 5377712 9.75 µM 1.71940357767937 0.0501829735481781 no 277 0.0427704556246018 279 2243908 SGTC_1694 st024011 44.9 µM 1.71293711514152 0.0508134353682597 no 278 0.0433620546104579 346 2787533 SGTC_1191 1487-1166 10.6 µM 1.71289501650282 0.0508175604341654 no 279 0.0433659276365909 394 3955771 SGTC_1822 st052468 42 µM 1.71089301043911 0.051014036488054 no 280 0.0435504325734598 279 2873678 SGTC_1187 1391-0724 117 µM 1.71041673412707 0.0510608669656503 no 281 0.0435944193744878 346 6997986 SGTC_765 1319-0117 244 µM 1.70690626782669 0.0514070943454136 no 282 0.0439197378238239 297 3487746 YGL099W LSG1 SGTC_2895 9054447 58.44 µM 1.70136833468216 0.0519570785387131 no 283 0.0444369217462968 277 2697450 SGTC_3256 9138902 49.47 µM 1.69966231343063 0.0521274459965805 no 284 0.0445972309859068 231 17228773 SGTC_932 2857-0803 154 µM 1.69236422129795 0.0528612660399351 no 285 0.0452882748983559 334 674898 SGTC_2258 7960471 200 µM 1.68668773173541 0.053437680987441 no 286 0.0458317061626233 250 2974708 SGTC_3254 9136651 49.47 µM 1.6742312427946 0.0547200199160088 no 287 0.047042580754591 356 16454030 SGTC_2700 st077718 96.8 µM 1.67413633710412 0.0547298825916468 no 288 0.047051903894321 292 904970 SGTC_3070 9117005 49.47 µM 1.67070317296576 0.0550876056187661 no 289 0.0473901609191677 248 8779016 SGTC_2210 7115885 190.385 µM 1.67048571911524 0.0551103255681713 no 290 0.0474116512953447 323 2927039 SGTC_624 k048-0052 28 µM 1.66921475067023 0.0552432666343194 no 291 0.0475374139110511 316 6835531 SGTC_2264 7948757 110.76 µM 1.66721167683946 0.0554532986528982 no 292 0.0477361608390245 328 2971411 SGTC_1933 st074711 15.9 µM 1.66571063040655 0.055611103514087 no 293 0.0478855318191702 363 17250958 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.66182500487353 0.0560212454786459 no 294 0.0482739335395431 418 688788 SGTC_574 1315-0397 40 µM 1.65637094749768 0.0566009614471562 no 295 0.0488233604066333 437 6794277 SGTC_1366 1683-0113 21.9 µM 1.65626048664117 0.0566127510654485 no 296 0.0488345393483972 315 708623 SGTC_3154 9100113 49.47 µM 1.65258178923497 0.057006489090102 no 297 0.0492080034170682 341 25237525 SGTC_1162 k048-0130 20.1 µM 1.6487048566445 0.0574237747196657 no 298 0.0496040573544887 338 6797406 SGTC_1381 2324-0066 62.1 µM 1.64635295361064 0.0576780856792715 no 299 0.0498455565631608 371 10885928 SGTC_1097 itavastatin 7.23 µM 1.63924842808181 0.058451677963621 no 300 0.0505807658796347 367 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3279 9140807 49.47 µM 1.63854999025736 0.0585281667342538 no 301 0.0506535074009628 315 45595718 SGTC_3171 9103192 49.47 µM 1.63674741838306 0.0587259368861769 no 302 0.0508416282928777 288 13018434 SGTC_1605 st000082 49.1 µM 1.63388450406644 0.0590411207316596 no 303 0.0511415520408361 327 1114022 SGTC_2417 cerulenin 830 nM 1.62572425018821 0.0599467833867255 no 304 0.0520041644486738 315 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3241 9133421 49.47 µM 1.62203319335564 0.0603599912855868 no 305 0.0523981205342096 244 17018221 SGTC_3099 9120367 49.47 µM 1.6207107071124 0.0605085827271169 no 306 0.0525398481258692 350 24824940 SGTC_2334 9017922 200 µM 1.61938674244404 0.0606576268063357 no 307 0.0526820387670519 337 3163164 SGTC_1562 morin hydrate 59.1 µM 1.617463620041 0.0608746318155146 no 308 0.0528891212284915 355 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_443 clozapine 122 µM 1.61239036185054 0.0614500110955645 no 309 0.0534385104360822 271 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2683 piperine 63.03 µM 1.60885349469497 0.0618536486557446 no 310 0.0538241902122582 313 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2682 pyrogallin 40.03 µM 1.60614435825001 0.0621642204859551 no 311 0.0541210977471516 406 822798 An ATP competetive kinase inhibitor. SGTC_3145 9085516 49.47 µM 1.60220754368926 0.0626176983611007 no 312 0.0545548612365154 363 25236195 SGTC_1957 st077035 62.4 µM 1.59747985467341 0.0631656791437736 no 313 0.0550793923624934 342 705593 SGTC_512 prima-1 270 µM 1.59682016859282 0.0632424385581245 no 314 0.0551528994258356 377 322968 A re-activator of the apoptotic function of mutant p53. SGTC_132 0417-1715 25.805 µM 1.594393204754 0.063525459201408 no 315 0.0554239967274563 383 6769098 SGTC_2777 climbazole 1.536 µM 1.59303897003279 0.0636838113223408 no 316 0.0555757244921397 403 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2808 7946468 45.46 µM 1.5925570148177 0.0637402408994992 no 317 0.0556298015460809 417 2970879 SGTC_1486 3970-0793 4.53 µM 1.58548050932465 0.0645732769488223 no 318 0.0564286009265936 349 2844330 SGTC_1255 0566-0045 221 µM 1.58515558547629 0.0646117286275097 no 319 0.0564654944367804 398 2788469 SGTC_2800 7887935 81.82 µM 1.57982120078248 0.0652455486403334 no 320 0.0570739094984978 368 2961002 SGTC_1810 st050138 53 µM 1.57571063449949 0.065737239746497 no 321 0.0575462527502883 314 3444541 SGTC_2400 5203494 178.7 µM 1.57467448618416 0.0658616322054734 no 322 0.0576657999543053 344 6777674 SGTC_3270 9137563 49.47 µM 1.5685335560683 0.0666026157206164 no 323 0.0583783325583936 321 17015724 SGTC_675 1309-0189 238 µM 1.56720803183758 0.0667634010459668 no 324 0.058533036844989 369 4246530 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.56672139905635 0.0668225046367552 no 325 0.0585899133345738 259 279621 SGTC_1629 st005085 44.9 µM 1.56622962035684 0.0668822743392166 no 326 0.0586474353377048 396 24207091 SGTC_2108 5365811 200 µM 1.56328872661636 0.067240567674212 no 327 0.0589923493550111 396 780283 SGTC_1249 0481-0015 10.2 µM 1.55617364242646 0.0681135459747052 no 328 0.0598334035913451 342 4227577 SGTC_698 k064-0052 127 µM 1.55486237941103 0.0682753806584694 no 329 0.0599894244196299 307 5088751 SGTC_661 1304-0007 33.6 µM 1.55161816048195 0.0686770539293604 no 330 0.0603768075942594 375 3117130 SGTC_747 3448-8087 38.7 µM 1.54830854454584 0.0690886995017589 no 331 0.0607740141115121 435 5168703 SGTC_771 0250-0039 27.3 µM 1.54711241199176 0.0692379397457177 no 332 0.0609180707359077 397 3005115 SGTC_2190 6049624 200 µM 1.54686302349535 0.0692690869623353 no 333 0.0609481395295567 330 2265554 SGTC_2732 terfenadine 20 µM 1.54669467454753 0.069290118898499 no 334 0.0609684439366389 324 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1750 st081859 2.357 µM 1.54628009750529 0.0693419332335355 no 335 0.0610184682264854 614 5291695 SGTC_2152 5568786 200 µM 1.54525022439151 0.0694707771653921 no 336 0.061142875101594 394 5399883 SGTC_361 000s-0510 1.45 µM 1.54402933977203 0.069623756639734 no 337 0.0612906125199311 425 660 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.54031637175985 0.0700905935062058 no 338 0.0617416274931711 472 65057 A dermal irritant. YDR527W RBA50 SGTC_792 4534-1957 155 µM 1.53921255754673 0.0702298409928654 no 339 0.0618762064626669 371 1717904 SGTC_344 k064-0035 6.43 µM 1.53875029042993 0.0702882197135246 no 340 0.0619326348563645 399 5088750 SGTC_1904 st060225 78 µM 1.53455639030985 0.070819564696837 no 341 0.0624464158624347 376 66595 SGTC_2600 tangeritin 87.95 µM 1.53411614740188 0.0708755196441891 no 342 0.0625005407561649 377 68077 A bioactive flavone. SGTC_2993 9054257 71.4286 µM 1.52659224730255 0.0718370669966148 no 343 0.0634312180185089 448 6470217 YGL055W OLE1 SGTC_1898 st060199 18.6 µM 1.52373730145301 0.0722045335487351 no 344 0.0637871737159396 374 688866 SGTC_963 1269-2853 151 µM 1.51903305159229 0.0728131685638212 no 345 0.0643770883604537 405 3668223 SGTC_1098 clofazimine 15.1 µM 1.51896292367888 0.0728222713232209 no 346 0.0643859143871261 465 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1467 k284-1082 293 µM 1.51669171726334 0.0731175502432945 no 347 0.0646722682387575 413 3334705 SGTC_2211 7117706 200 µM 1.51196400624299 0.0737351360506826 no 348 0.0652715097280879 376 822771 SGTC_2923 7992654 58.14 µM 1.50746566041368 0.0743264539939297 no 349 0.0658456697383898 410 2985126 SGTC_1670 st016595 4.04 µM 1.50526086495853 0.0746175985794026 no 350 0.0661285112196287 424 597879 SGTC_201 4262-0159 12.803 µM 1.50484537719596 0.0746725613283591 no 351 0.066181917171009 349 1341029 SGTC_2937 9044753 11.33 µM 1.50072453811083 0.0752193599861058 no 352 0.0667134118177388 466 6465530 YGL099W LSG1 SGTC_1168 k815-0004 80.5 µM 1.49450480152005 0.0760504373779088 no 353 0.0675218639378141 419 642433 SGTC_572 0960-0087 17.7 µM 1.49442370336648 0.076061319646202 no 354 0.0675324549947505 504 6796365 SGTC_1674 st016616 23.6 µM 1.49122817092838 0.0764910608876027 no 355 0.0679507999526906 430 625830 SGTC_972 1319-0219 195 µM 1.48936159591629 0.0767429345625409 no 356 0.0681960878742166 433 23903702 SGTC_1347 1493-0251 600 nM 1.48810082000977 0.0769134188609632 no 357 0.0683621536337719 456 3986378 SGTC_138 0850-0259 40.9225 µM 1.48781274032307 0.0769524138709482 no 358 0.0684001424160512 602 6813004 SGTC_2116 5511452 16.8835 µM 1.48378940124192 0.0774985923066296 no 359 0.0689323998785607 444 870744 SGTC_1459 k035-0031 35.7 µM 1.48150199976065 0.0778104226832168 no 360 0.0692364262115523 371 3877128 YMR208W ERG12 SGTC_1449 4112-4002 201 µM 1.47747220513484 0.0783621004216144 no 361 0.069774551774002 414 2059539 SGTC_40 0327-0103 19.753 µM 1.47310487194856 0.0789633304814029 no 362 0.0703613799800947 434 409036 SGTC_962 1254-0300 21.5 µM 1.46984202764388 0.0794147863626122 no 363 0.0708022717858906 429 7340576 SGTC_1395 3486-0190 4.35 µM 1.46979087851845 0.0794218790123338 no 364 0.0708092001703157 458 6748079 SGTC_1373 2887-0003 58.5 µM 1.46628415781688 0.0799092863080493 no 365 0.0712854447704065 432 776948 SGTC_1879 gemcitabine 100 µM 1.45896004783961 0.0809345723756957 no 366 0.0722880521116541 431 60750 A nucleoside analog which inhibits DNA replication. SGTC_3182 9108849 49.47 µM 1.45874259539768 0.0809651641523354 no 367 0.0723179838095318 489 17133045 SGTC_428 3448-4153 16.5 µM 1.45725376467787 0.0811748512384168 no 368 0.0725231722058074 400 3834874 SGTC_668 1682-0499 62.6 µM 1.45588442918641 0.0813680701163139 no 369 0.0727122853808844 522 682214 SGTC_3243 9134147 49.47 µM 1.45546562468981 0.0814272343775245 no 370 0.0727702000554237 412 24282180 SGTC_1329 1447-1697 50.6 µM 1.45181505042691 0.0819443235629061 no 371 0.0732765189695746 461 2840515 SGTC_1697 st025554 27.742 µM 1.44740430560228 0.0825723841516472 no 372 0.0738918602853937 416 1269519 SGTC_1015 4130-4525 82 µM 1.44075256889569 0.0835263898039817 no 373 0.0748272988381486 468 1363237 SGTC_1940 st075990 51.1 µM 1.44035788887277 0.0835832548525115 no 374 0.0748830856312216 507 1084979 SGTC_1046 2001-0062 216 µM 1.43680268843719 0.0840967959078629 no 375 0.0753870331476397 464 739778 SGTC_652 0437-0092 114 µM 1.433452772818 0.0845828481267596 no 376 0.0758642431243775 412 3091274 SGTC_1408 3909-7976 48.8 µM 1.43290796205841 0.0846620956461498 no 377 0.0759420707926497 506 24152374 SGTC_630 4356-0227 183 µM 1.43173481699531 0.0848329289548186 no 378 0.0761098640742537 437 779312 SGTC_3318 9139014 38.6185 µM 1.4298042601476 0.0851146189402202 no 379 0.0763866030277134 423 16643984 SGTC_2378 9074213 121.43 µM 1.42267243957215 0.0861613108991861 no 380 0.0774155668366798 495 657714 SGTC_985 1493-0307 8.71 µM 1.42238376028509 0.0862038803822728 no 381 0.077457437470233 396 3278274 SGTC_2085 5307070 144.047 µM 1.4220398794278 0.0862546105781868 no 382 0.0775073370955411 416 2840351 SGTC_82 0054-0107 293.755 µM 1.41965957421831 0.0866063717215773 no 383 0.0778534062875367 421 3104697 SGTC_2405 ticlatone 3.52 µM 1.41691828274414 0.0870128066152653 no 384 0.0782534102569009 454 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2174 5790901 200 µM 1.41645381741445 0.0870818110256633 no 385 0.0783213382832774 457 786020 SGTC_77 0828-0286 12.516 µM 1.40609493640301 0.0886314417869715 no 386 0.0798479678956397 494 745345 SGTC_777 1315-0167 517 µM 1.40489776962498 0.0888118470243709 no 387 0.0800258399598974 462 4221767 SGTC_905 2-aminofluorene 215 µM 1.40362625627716 0.08900375507701 no 388 0.0802150861412387 503 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3191 9110352 49.47 µM 1.40329057630237 0.0890544703349708 no 389 0.0802651035919283 429 17122424 SGTC_2775 cyproheptadine 69.59 µM 1.3982560058731 0.089817686468361 no 390 0.0810181019603518 471 2913 A selective serotonin reuptake inhibitor. SGTC_1659 st012954 42.1 µM 1.39697350649994 0.0900128818325674 no 391 0.0812107691158241 461 24207262 SGTC_1963 st076565 50.3 µM 1.39469252786071 0.0903608234829068 no 392 0.081554289558937 482 4914280 SGTC_2951 9072950 58.06 µM 1.39403253987522 0.0904616844507604 no 393 0.0816538893111798 502 16488155 SGTC_1177 0983-0204 23.6 µM 1.39126715347045 0.0908852065010784 no 394 0.0820722151389627 517 766818 SGTC_3066 9117245 49.47 µM 1.39060673921796 0.0909865669572331 no 395 0.0821723558175072 487 17176980 SGTC_3150 9097574 49.47 µM 1.38528178042713 0.0918069078775754 no 396 0.0829831613019899 441 17217476 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.3830851459818 0.0921469037766169 no 397 0.0833193798508245 500 5377381 SGTC_1783 st039459 87.517 µM 1.37546910640007 0.0933329358785569 no 398 0.0844930285552297 548 729761 SGTC_1500 4488-1866 171 µM 1.37370466344854 0.0936093114115851 no 399 0.0847666942697151 535 2900003 SGTC_3350 9150499 3.57 µM 1.37214707344542 0.0938537880949958 no 400 0.0850088288944492 568 4910996 YPR165W RHO1 SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.36962141828628 0.0942512117830435 no 401 0.0854025550652659 486 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2049 5262831 67.185 µM 1.36743413107437 0.0945963935012343 no 402 0.0857446351394512 498 763417 SGTC_1786 berberine 21.6 µM 1.3671513935574 0.0946410810025608 no 403 0.0857889285396453 515 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_226 1,3-diallylurea 8.28947 mM 1.36567443239817 0.09487477205407 no 404 0.0860205863682699 445 74537 YKL182W FAS1 SGTC_1782 st039423 80.636 µM 1.36537706653782 0.094921873913668 no 405 0.0860672840451343 478 2068169 SGTC_1708 st033234 31.827 µM 1.36451512676739 0.0950584999243877 no 406 0.0862027483220365 538 674664 SGTC_1158 4092-0494 91.8 µM 1.36035845166649 0.0957194081170978 no 407 0.0868582598306122 523 1148199 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.3592788713756 0.0958916123007296 no 408 0.0870291183320454 434 61125 An anti-inflammatory. SGTC_3049 9092223 49.47 µM 1.35847361186501 0.0960202077815245 no 409 0.0871567251457623 475 8623917 SGTC_2728 chlorpromazine 9.18 µM 1.35656852657125 0.0963249441389033 no 410 0.0874591739218113 386 2726 A thorazine and dopamine antagonist. SGTC_2016 5121758 140 µM 1.351239556294 0.0971811370384903 no 411 0.0883093535721864 567 2795203 SGTC_1705 st027868 56.3335 µM 1.35073579931325 0.0972623624792106 no 412 0.0883900400978786 491 292948 SGTC_2254 7938975 95.19 µM 1.34559182053053 0.098094627037608 no 413 0.0892170954964814 620 2969277 SGTC_2247 cerulenin 830 nM 1.34542259303196 0.0981220953981677 no 414 0.0892444016096044 519 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1777 st045864 34.765 µM 1.34378240700338 0.0983886161607055 no 415 0.0895093800755973 516 4691462 SGTC_346 4513-0042 7.16 µM 1.34058811350413 0.0989091912538464 no 416 0.0900271093070947 542 2827372 SGTC_2695 st077686 51.995 µM 1.34015581500316 0.0989797976152669 no 417 0.0900973465921248 477 2876092 SGTC_7 0192-1582 4.227 µM 1.3397468750221 0.0990466228111933 no 418 0.0901638261877938 632 252616 SGTC_516 3992-2719 87.3 µM 1.33844440565457 0.0992596802551722 no 419 0.0903758058232765 461 5350887 YDR037W KRS1 SGTC_198 3454-2873 16.191 µM 1.33815675432352 0.0993067792934337 no 420 0.0904226715361335 514 710957 SGTC_1358 1509-0022 2.48 µM 1.33728095444432 0.0994502803535243 no 421 0.0905654727059366 533 3258434 SGTC_2170 morpholine 200 µM 1.3350918315127 0.0998096340708932 no 422 0.0909231463064037 503 121171 Reacts with secondary amines. SGTC_1862 st057513 3.81 µM 1.33315475761602 0.100128403072065 no 423 0.0912405114294962 496 5393163 SGTC_3173 9105693 49.47 µM 1.32610266533566 0.101295188530836 no 424 0.0924028467085376 548 17096658 SGTC_449 xestospongin c 11.1929 µM 1.32580230187523 0.101345103408025 no 425 0.0924525951806277 562 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1960 st011366 51.8 µM 1.32422320276056 0.101607815361089 no 426 0.0927144635397047 500 3972846 SGTC_2465 5809242 33.21 µM 1.32351657193627 0.101725536766819 no 427 0.0928318244746771 488 2731748 SGTC_172 1112-0046 2.638 µM 1.31616720943603 0.102955797328794 no 428 0.0940589634249841 471 2802135 YIL048W NEO1 SGTC_3352 9151559 45.5865 µM 1.31585143230804 0.103008898581651 no 429 0.0941119563215287 519 17159339 SGTC_801 0866-0028 10.1 µM 1.31416309586672 0.1032931477117 no 430 0.0943956623156519 569 6849771 SGTC_3078 9116413 49.47 µM 1.31141377102654 0.10375724337417 no 431 0.094859004391954 487 17177322 SGTC_1240 0356-0016 42.1 µM 1.31109058976374 0.103811896704302 no 432 0.0949135798164474 541 4305613 SGTC_3087 9117406 49.47 µM 1.31083773352634 0.103854671895824 no 433 0.0949562956238172 520 42546093 SGTC_1510 1123-0200 71.5 µM 1.3104134848333 0.103926469927691 no 434 0.095027997115504 623 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_224 benfluorex 43.875 µM 1.31023270909651 0.103957074574179 no 435 0.0950585618048081 419 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2136 5328288 199.296 µM 1.30766685868338 0.104392168231222 no 436 0.0954931644445837 454 262395 SGTC_2760 etidronate 98.04 µM 1.29336365020058 0.106841769749443 no 437 0.0979426579674864 533 3305 A chelator and antioxidant. SGTC_2969 9091408 28.7 µM 1.29231496680888 0.107022988102259 no 438 0.0981240454449232 543 4286311 SGTC_1181 1222-0449 220 µM 1.29213227771324 0.107054580461489 no 439 0.0981556697603392 544 658318 SGTC_1126 isoteolin 1.0172 µM 1.28286393838474 0.108666187925823 no 440 0.0997698743970868 551 133323 SGTC_386 1509-0011 3.07 µM 1.28083467391072 0.109021359098 no 441 0.100125871087288 654 3107280 SGTC_2265 7929201 200 µM 1.27960911302974 0.109236266095383 no 442 0.100341321620458 551 1265108 SGTC_719 2810-4230 27.3 µM 1.27781690320313 0.109551084986827 no 443 0.100656996477562 523 721079 SGTC_2300 7976697 71.57 µM 1.27167634713658 0.110634671783971 no 444 0.101744068943756 483 2236109 SGTC_1378 2093-0007 380 nM 1.26996711968082 0.110937650913686 no 445 0.102048171308165 569 3618014 SGTC_2606 farnesol 9.78 µM 1.26822831837585 0.111246481725341 no 446 0.102358213466578 574 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3172 9105863 49.47 µM 1.26822513645246 0.111247047434623 no 447 0.102358781456163 465 2348785 SGTC_2227 7312221 64.1025 µM 1.26765321314012 0.111348762260094 no 448 0.102460909924333 522 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2157 5649910 96.377 µM 1.26582156163269 0.1116749638664 no 449 0.10278848689387 585 2858091 SGTC_2822 7994718 71.43 µM 1.26555584751197 0.111722342021453 no 450 0.102836070986495 489 1018011 SGTC_2734 clemastine 41.6 µM 1.262396334912 0.112286801098736 no 451 0.103403103695535 405 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2009 4012297 12.05 µM 1.26142073207878 0.112461507395449 no 452 0.103578651340485 548 45595307 SGTC_3259 9138485 49.47 µM 1.25913472292642 0.1128716353876 no 453 0.103990837243164 628 17646153 SGTC_157 1348-1695 65.819 µM 1.25861820666759 0.112964450152651 no 454 0.104084133805641 650 5380510 SGTC_2897 9048598 12.99 µM 1.25638093607706 0.113367102768895 no 455 0.104488945059066 550 6467404 SGTC_2259 7964009 200 µM 1.25416297818255 0.113767288999736 no 456 0.10489138663196 539 313134 SGTC_3011 9081274 71.4286 µM 1.25383582180852 0.11382640294256 no 457 0.10495084298532 620 6625322 SGTC_1424 4048-1941 275 µM 1.25305215691573 0.113968092500145 no 458 0.105093362945379 628 X1424 SGTC_2357 9067248 200 µM 1.25161619712547 0.114228045425932 no 459 0.105354874852962 530 9150235 SGTC_2842 9000675 19.48 µM 1.24446113996331 0.115529625034941 no 460 0.106664946462154 539 2989072 SGTC_1840 st055363 71 µM 1.23781535814002 0.116747969742073 no 461 0.107892266211023 520 676033 SGTC_3245 9134821 49.47 µM 1.23739991345726 0.116824432941478 no 462 0.107969325461433 592 17014901 SGTC_2283 7944793 200 µM 1.23597568332516 0.117086834006286 no 463 0.108233801285501 596 2970533 SGTC_2241 6772625 37.8075 µM 1.22738735098529 0.118678006502748 no 464 0.109838519146182 567 2285411 SGTC_1298 1079-1278 263 µM 1.22569358221136 0.118993608592668 no 465 0.110157003114181 633 2840950 SGTC_187 1488-2104 32.728 µM 1.22488128350184 0.119145175322566 no 466 0.110309976655732 622 2852859 SGTC_413 propylparaben 100 µM 1.22383196898869 0.119341168469893 no 467 0.110507810854693 578 7175 A pharmaceutical preservative. SGTC_451 chloral hydrate 100 µM 1.22345308283646 0.119411993490264 no 468 0.110579307227912 673 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.22085873078628 0.119897751408969 no 469 0.111069756154186 631 5379071 SGTC_1368 1852-0141 284 µM 1.21969934000753 0.120115281683419 no 470 0.111289435944493 583 2838987 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.21955890840535 0.120141648983805 no 471 0.111316065838508 669 688761 SGTC_2319 6033012 152.6 µM 1.21563453364802 0.120880135838574 no 472 0.112062086434914 542 847246 SGTC_2514 salinomycin 42.74 µM 1.21401588406881 0.121185661124945 no 473 0.112370829325801 676 23682228 A polyether potassium ionophore. SGTC_1613 st002381 52.1 µM 1.21398418542771 0.121191649762352 no 474 0.112376881618975 586 551167 SGTC_1236 0330-0013 258 µM 1.21096210061835 0.121763550579285 no 475 0.112954965101011 587 4617066 SGTC_3306 9127676 59.7925 µM 1.20808528855973 0.122309719098102 no 476 0.113507228927422 579 41905287 SGTC_614 0462-0418 107 µM 1.20637736093766 0.122634784898291 no 477 0.113836010554952 546 5188303 SGTC_781 4335-2806 94.4 µM 1.20448369043548 0.122995910666446 no 478 0.114201341063849 707 845254 SGTC_5 0352-0601 109.883 µM 1.20412999241088 0.123063443946664 no 479 0.114269669600746 562 762456 SGTC_1043 0916-0009 19.3 µM 1.20411468468638 0.123066367311479 no 480 0.114272627453943 717 3101130 SGTC_1637 st007924 17.4 µM 1.20384160814281 0.123118525787089 no 481 0.114325402154245 610 683336 SGTC_742 0kpi-0133 140 µM 1.20305943942238 0.123268008205137 no 482 0.114476659909335 639 2728852 SGTC_1438 4092-1045 4 µM 1.20090826356036 0.12367978104547 no 483 0.114893394208778 630 1351342 SGTC_908 3448-7491 47.7 µM 1.20011950088011 0.123831005120047 no 484 0.115046466481049 712 1203031 SGTC_27 0485-0001 32.618 µM 1.1987359439567 0.124096577567061 no 485 0.115315318473435 515 2054479 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.19780148622287 0.124276171159206 no 486 0.115497154244532 561 364106 SGTC_3331 9141060 1.957 µM 1.19352989855711 0.125099442844362 no 487 0.116330954961422 581 4906567 YPR165W RHO1 SGTC_487 nimodipine 119 µM 1.19344036974124 0.125116738569512 no 488 0.116348476284885 509 4497 L-type voltage-gated calcium channels inhibitor SGTC_1834 st055981 52.8 µM 1.19222786842084 0.125351141471927 no 489 0.11658595442715 651 471719 YDL150W RPC53 SGTC_584 0986-0246 15.4 µM 1.19153526415792 0.125485174441127 no 490 0.116721760703014 686 53315 YDR232W HEM1 SGTC_779 1360-0071 233 µM 1.18914932442773 0.125947667795996 no 491 0.117190455835373 694 7566 SGTC_1864 st057645 30.4 µM 1.18738916542009 0.126289620090213 no 492 0.117537075825301 598 688666 SGTC_1998 st075797 76.8 µM 1.18649603750699 0.126463378416838 no 493 0.11771323269817 705 24208315 SGTC_3092 9117248 49.47 µM 1.18624384358821 0.1265124729666 no 494 0.117763008201426 683 17141857 SGTC_674 0498-0004 451 µM 1.18484007852466 0.126785986307046 no 495 0.118040341455486 607 4231473 SGTC_2558 carylophyllene oxide 100 µM 1.18213331204163 0.127314541618505 no 496 0.118576404209132 676 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2553 4-methylesculetin 85.09 µM 1.18113280220453 0.127510300466355 no 497 0.118774985417899 644 5319502 SGTC_1131 3454-3128 32.3 µM 1.1809984938412 0.127536595044365 no 498 0.118801660818363 669 710982 SGTC_1273 0849-0096 14.1 µM 1.17787740030905 0.128148697446161 no 499 0.119422742993624 646 5286025 SGTC_2068 5226020 147 µM 1.17607972588738 0.128502178230126 no 500 0.119781509354142 676 1810509 SGTC_2697 mebhydrolin 72.4 µM 1.17399791554099 0.128912374273563 no 501 0.120197930273232 700 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2727 riluzole 51.77 µM 1.17279423224797 0.129149959709035 no 502 0.120439165828052 589 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1066 ketoconazole 628 nM 1.16808100454334 0.130083186743791 no 503 0.121387045854471 705 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2425 5628681 7.85 µM 1.16794120742944 0.130110937892724 no 504 0.121415240404005 741 5714958 SGTC_89 0302-0250 142.109 µM 1.16635056319485 0.130426985489722 no 505 0.121736368834567 698 4203518 YLR208W SEC13 SGTC_2735 sertaconazole 140 nM 1.16397494680131 0.130899988449021 no 506 0.122217082424189 586 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1623 st003709 20.3 µM 1.16308537920354 0.131077412680051 no 507 0.122397431765996 715 16192618 SGTC_2726 cimetidine 79.27 µM 1.15729133910842 0.132237098546776 no 508 0.12357667541306 579 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2418 pentamidine 31.67 µM 1.15440296647333 0.132817844743141 no 509 0.124167499774066 617 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2957 9076800 11.52 µM 1.15316446360209 0.133067399626949 no 510 0.124421443229206 594 16459615 SGTC_253 dyclonine 31.25 µM 1.15257292764562 0.133186706293481 no 511 0.12454286022014 718 3180 An oral anasthetic. SGTC_627 1391-0720 175 µM 1.15078067308826 0.133548634746734 no 512 0.124911238896066 641 997839 SGTC_695 3505-6186 243 µM 1.14996411841842 0.133713754127353 no 513 0.125079325108633 679 1819379 SGTC_2185 6113692 200 µM 1.14948940073267 0.133809813526318 no 514 0.125177117418284 609 874150 SGTC_751 0833-0568 350 µM 1.14851936052311 0.134006249192335 no 515 0.12537711263899 658 6954252 SGTC_964 1287-0107 19.4 µM 1.14390994573223 0.13494237485 no 516 0.126330492971344 711 51516812 YPR165W RHO1 SGTC_1529 apigenin 74 µM 1.14250654923989 0.135228279165305 no 517 0.126621762655255 693 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2342 7990637 118.86 µM 1.14100387553948 0.13553486863081 no 518 0.126934155114699 696 2033102 YER133W GLC7 SGTC_1271 0832-2808 169 µM 1.14054175985597 0.135629249451746 no 519 0.127030332612106 695 3663794 SGTC_909 3448-9333 149 µM 1.13893193150463 0.13595838648743 no 520 0.127365773013205 620 3344074 SGTC_867 0518-0118 155 µM 1.13731152183591 0.13629023875369 no 521 0.127704039918644 685 6848158 SGTC_6 0844-0013 19.835 µM 1.13645436475196 0.136466004428472 no 522 0.127883227152674 901 1584900 SGTC_74 000s-0487 160.283 µM 1.13313091734463 0.137148964714728 no 523 0.128579639772333 648 677548 SGTC_1642 st009582 77.7 µM 1.13097917830093 0.137592385002181 no 524 0.12903192764212 638 6739311 SGTC_345 1362-0200 395 µM 1.13056909072233 0.137677004823301 no 525 0.12911825159734 639 1419823 SGTC_951 1171-0579 82.7 µM 1.12919310305726 0.137961193481625 no 526 0.129408191275841 753 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_942 3253-1115 227 µM 1.12039699312289 0.139787344095843 no 527 0.131272312861247 682 46497897 SGTC_826 1683-5028 118 µM 1.12019018484749 0.1398304761265 no 528 0.131316362835275 677 722377 SGTC_2522 biochanin a 4.94 µM 1.11937894420454 0.139999756190291 no 529 0.13148925489579 651 5280373 A possible chelator. SGTC_2674 ligustilide 100 µM 1.11908583413348 0.140060953151775 no 530 0.131551761305376 648 5319022 A signalling regulator. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.11683668367258 0.140531146639169 no 531 0.132032080408991 739 676296 Flavone; oxidizing agent. SGTC_339 3091-4833 71.4 µM 1.11273759270213 0.141390830518255 no 532 0.132910572556088 699 3240077 SGTC_1768 st044301 37.178 µM 1.11270864814092 0.141396913576439 no 533 0.132916790053084 720 3931349 SGTC_1531 st059297 52.4 µM 1.10616989003058 0.14277566187302 no 534 0.134326496357865 711 7566702 SGTC_2299 7976368 114.88 µM 1.10560762870027 0.14289464196778 no 535 0.134448193222677 691 2979718 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.10538674005035 0.142941402533452 no 536 0.134496023467819 692 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2119 5528445 120.635 µM 1.10378002107109 0.143281844734431 no 537 0.134844286747909 705 791935 SGTC_3020 9089140 49.47 µM 1.10304188166921 0.143438429993924 no 538 0.135004488874017 673 17217859 SGTC_2783 7738165 71.43 µM 1.09939168252345 0.144214463176097 no 539 0.135798628573617 606 17201110 SGTC_859 0439-0102 54.6 µM 1.09861736310908 0.1443794468813 no 540 0.135967500478782 772 610143 SGTC_2343 7990716 14.84 µM 1.09727826947342 0.144665066745107 no 541 0.136259883614634 721 6456862 SGTC_732 3970-1727 52.7 µM 1.09543806999331 0.145058189677979 no 542 0.136662381617474 711 1275699 SGTC_2686 alizarin 95.37 µM 1.09432924361187 0.145295415785804 no 543 0.136905302010014 653 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2072 5231554 129 µM 1.09228900927207 0.145732592116196 no 544 0.137353044841344 735 789545 SGTC_831 k061-1017 217 µM 1.09113476687765 0.145980311538097 no 545 0.137606793317827 859 1240153 SGTC_1404 3909-7820 48.3 µM 1.0891790410097 0.146400687988461 no 546 0.138037469784429 695 23741373 SGTC_312 4092-0653 6.84 µM 1.08880488349323 0.146481204365219 no 547 0.138119968819466 812 1148278 SGTC_2461 5755302 26.15 µM 1.08832133639821 0.146585304724061 no 548 0.138226637262556 743 2788904 SGTC_3286 9117135 37.221 µM 1.08544051584838 0.147206530621122 no 549 0.138863297988525 683 3438150 SGTC_1074 carmofur 3.8 µM 1.08511962323902 0.147275837624833 no 550 0.138934338590314 779 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1111 tnp00062 510.699 nM 1.08265312950739 0.147809285744913 no 551 0.139481207735949 747 676306 SGTC_3217 9129673 49.47 µM 1.08182102379416 0.147989543328088 no 552 0.139666031439807 684 17248312 SGTC_2564 betulinic acid 100 µM 1.08143845080564 0.14807246879172 no 553 0.139751062744421 775 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2878 9043973 25.97 µM 1.07930034820491 0.148536490472741 no 554 0.140226928866482 703 6465167 SGTC_410 α-linolenic acid 100 µM 1.0743409603245 0.149616541146953 no 555 0.141334946598125 760 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1247 0448-0043 5.84 µM 1.07263335161999 0.149989632290808 no 556 0.141717827278315 756 3089013 YGL099W LSG1 SGTC_1954 st077032 68.9 µM 1.06942788198982 0.150691661222246 no 557 0.142438454610825 638 698907 SGTC_3059 1327-0034 3 µM 1.06882381635551 0.150824202075164 no 558 0.142574532751753 726 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1466 k213-0079 57.5 µM 1.06835519319596 0.150927078305201 no 559 0.142680160240865 745 3657981 SGTC_2650 prasterone 100 µM 1.06828097748399 0.150943375066557 no 560 0.142696893287096 646 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3220 9131269 49.47 µM 1.06818155743047 0.150965208193953 no 561 0.142719311109499 734 17722206 SGTC_2936 9038235 15.59 µM 1.06801096357227 0.151002676332263 no 562 0.142757783170491 703 4749415 SGTC_2062 5245942 200 µM 1.06713340144163 0.151195516230405 no 563 0.142955800400237 762 1376160 SGTC_1023 4482-3888 16 µM 1.06621695905769 0.151397074674006 no 564 0.143162788789574 740 3303168 SGTC_2236 dapsone 200 µM 1.06402947351202 0.151878902907041 no 565 0.14365767396716 778 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2802 7925815 54.55 µM 1.06396308985356 0.151893540866043 no 566 0.143672710283163 734 1262923 SGTC_648 0375-0473 33.3 µM 1.06354607184097 0.151985517050806 no 567 0.143767191776736 767 1713139 SGTC_1604 st002052 72.4 µM 1.06256972774119 0.152201001112867 no 568 0.143988560669579 732 6254834 YHR062C RPP1 SGTC_3097 9117246 49.47 µM 1.05862166020018 0.153074427216498 no 569 0.14488605916407 737 16423892 SGTC_662 k832-1615 104 µM 1.05711896642689 0.153407737508578 no 570 0.145228648104285 729 5878478 SGTC_1955 wogonin 32.4 µM 1.05665463617856 0.153510827072273 no 571 0.145334617745939 730 5281703 A flavanone. SGTC_2706 st078239 82.5 µM 1.05474795003115 0.153934626181095 no 572 0.145770307704786 754 15434492 SGTC_2628 lathosterol 100 µM 1.05228058006544 0.154484196622888 no 573 0.146335419405769 750 6710616 SGTC_2484 5809818 12.04 µM 1.05043735165916 0.154895594024593 no 574 0.146758540124725 717 2870548 SGTC_3346 9158254 43.5805 µM 1.04882301688302 0.155256497638401 no 575 0.147129790968705 750 17639500 SGTC_2438 5259590 200 µM 1.04869618874855 0.155284875063107 no 576 0.147158984466689 783 1201127 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.04851568950758 0.155325267143644 no 577 0.147200538759459 744 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2922 7999257 32.47 µM 1.04360984325448 0.156425751538122 no 578 0.14833296847204 684 2988377 SGTC_2313 7726885 200 µM 1.04317998723773 0.156522421341395 no 579 0.148432470228886 731 726423 SGTC_3184 9108758 49.47 µM 1.04298653212476 0.156565940061373 no 580 0.148477265188964 761 902885 SGTC_2512 diallyl trisulfide 49.23 µM 1.0425843010875 0.156656449494341 no 581 0.14857043161284 717 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_3006 9075424 71.4286 µM 1.04238450431076 0.156701420269725 no 582 0.148616723898725 715 7465181 SGTC_993 3909-8757 62.7 µM 1.04204508727033 0.156777836611726 no 583 0.148695387864781 698 4288324 YLR208W SEC13 SGTC_1072 oxiconazole 14.9 nM 1.03785570839671 0.157723052337526 no 584 0.149668618289675 786 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2267 7931562 200 µM 1.03657296818824 0.158013213664525 no 585 0.149967458356516 689 934880 SGTC_2366 9070441 60.58 µM 1.03577115057728 0.158194766122043 no 586 0.150154459805366 773 6837235 SGTC_3136 9095672 49.47 µM 1.03564815283526 0.158222628130412 no 587 0.150183159320353 678 17217380 SGTC_2592 piperlongumine 83.33 µM 1.03557613206527 0.158238944097819 no 588 0.150199965888337 703 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1064 honokiol 6.76 µM 1.03297909046207 0.158828029385379 no 589 0.150806841974653 771 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2881 9058953 51.95 µM 1.03247310609515 0.158942968592032 no 590 0.150925270029474 812 17122249 SGTC_453 enantio-paf c16 10 µM 1.03046844364522 0.159398882548689 no 591 0.151395079142266 881 13871343 A lipid and platelet activating factor SGTC_197 4544-0043 41.561 µM 1.03012990964037 0.15947595867376 no 592 0.151474513247673 785 896523 SGTC_466 geldanamycin 89.2 µM 1.02936738739023 0.159649656169119 no 593 0.151653534050728 660 5288382 HSP90 inhibitor. SGTC_1019 4262-0212 3.4 µM 1.0286036052932 0.15982376471355 no 594 0.151832991553683 835 4677213 SGTC_622 1348-1566 26.3 µM 1.02763508267531 0.160044723596383 no 595 0.152060757514107 820 7340407 SGTC_359 0081-0058 15.9 µM 1.02609085292172 0.160397437326994 no 596 0.152424380732976 704 3494159 SGTC_405 ebelactone b 50 µM 1.02345454331257 0.161000763202626 no 597 0.153046490954956 787 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_998 3996-0085 177 µM 1.02316762228539 0.16106651503396 no 598 0.153114299328584 859 715391 SGTC_1868 st057644 42.7 µM 1.02232252157814 0.161260283086658 no 599 0.153314138625375 832 688665 SGTC_1309 pyrazolanthrone 13.4 µM 1.02219657516485 0.161289173595752 no 600 0.153343935714245 832 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1200 1643-0193 18.4 µM 1.02172905948101 0.161396445285769 no 601 0.1534545766742 830 5403974 SGTC_3274 9138298 49.47 µM 1.02168421947478 0.161406736290657 no 602 0.15346519116342 820 17015756 SGTC_2349 9023730 187.07 µM 1.02133380696145 0.161487172446825 no 603 0.153548157272906 776 4126287 SGTC_2940 9060638 45.86 µM 1.0213148235277 0.161491530784099 no 604 0.153552652771032 770 4027022 SGTC_827 3253-0474 693 µM 1.01540509789847 0.162852051252423 no 605 0.154956381987773 826 5402065 SGTC_2587 piperic acid 92.2 µM 1.01466880756033 0.163022078601882 no 606 0.155131863901495 721 5370536 SGTC_3032 9089427 49.47 µM 1.01292762329465 0.163424619340097 no 607 0.155547366485233 750 17173707 SGTC_2561 acetosyringone 100 µM 1.01234299994317 0.163559921841351 no 608 0.155687040902916 898 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1184 1269-1718 139 µM 1.0116029740306 0.163731294269648 no 609 0.155863961673178 794 5403821 SGTC_1617 st002906 78 µM 1.01087626607824 0.163899695962441 no 610 0.156037827408171 816 5150859 SGTC_1235 benzylparaben 21.5 µM 1.01062298948885 0.163958414728084 no 611 0.156098454156793 746 7180 SGTC_1716 st033144 30.6155 µM 1.00893023251435 0.164351208039559 no 612 0.15650404743986 824 674617 SGTC_2233 sulbentine 40.3845 µM 1.0083164837758 0.164493775043149 no 613 0.156651276050264 864 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_264 promethazine 12.5 mM 1.00831189048077 0.164494842316581 no 614 0.156652378252657 929 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1673 st016611 27.3 µM 1.00493272760467 0.165281222634524 no 615 0.157464622039008 822 5226799 SGTC_3102 9121669 49.47 µM 1.00397534552085 0.165504460901387 no 616 0.157695248667219 760 41905072 SGTC_861 0443-0273 110 µM 1.0020241095305 0.16596004529765 no 617 0.158165974360892 806 6149169 SGTC_154 3389-1638 511.116 µM 1.00008760706859 0.166412990152398 no 618 0.158634056514159 706 5238686 SGTC_1534 6-azauridine 81.6 µM 0.9957730331385 0.167425029480765 no 619 0.159680217834585 866 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2730 imipramine 71.33 µM 0.994978436685038 0.167611843930482 no 620 0.159873376010929 920 3696 A tricyclic antidepressant. SGTC_171 k064-0041 9.68 µM 0.991484988698475 0.168434766777891 no 621 0.16072440937339 715 53325 SGTC_2467 5474540 200 µM 0.990410250281407 0.16868845578379 no 622 0.160986818661087 812 5413519 SGTC_1469 k284-2957 126 µM 0.988137127506151 0.169225828599273 no 623 0.161542747380456 812 23884841 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.986020247668653 0.169727252319562 no 624 0.162061588549176 808 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_162 k030-0015 37.8 µM 0.983114395077367 0.170417109531257 no 625 0.162775570132301 881 1809920 YMR134W ERG29 SGTC_2026 5148700 152 µM 0.982244840636293 0.170623892698136 no 626 0.162989620808959 820 79838 SGTC_442 cape 100 µM 0.980149972137619 0.171122719262007 no 627 0.163506047500877 798 5281787 SGTC_2785 7756463 72.73 µM 0.978053013349696 0.171622976645272 no 628 0.164024052540133 817 2201551 SGTC_2972 9093619 59.92 µM 0.977986387994499 0.171638886308675 no 629 0.164040528221103 798 25236256 SGTC_566 0958-0068 16.5 µM 0.977854332522882 0.171670423005411 no 630 0.164073187187024 756 6815365 SGTC_2869 9037858 32.47 µM 0.977637653866557 0.171722176923568 no 631 0.164126783659971 807 27187042 SGTC_372 0155-0182 15.9 µM 0.976331620987953 0.172034335254213 no 632 0.164450077443782 888 771486 SGTC_3085 9117376 49.47 µM 0.974391765431284 0.172498653318927 no 633 0.164931028272092 833 16480349 SGTC_118 0083-0097 135.343 µM 0.974306020313119 0.172519195443142 no 634 0.164952308167249 1014 5207356 SGTC_1057 3448-5381 134 µM 0.97357671222665 0.172693980255661 no 635 0.165133376924076 861 5497911 SGTC_1481 3346-2004 36 µM 0.973171470801482 0.172791148541745 no 636 0.165234043709303 860 2770522 SGTC_620 0109-0052 432 µM 0.973135097503911 0.172799871789812 no 637 0.165243081210607 851 493037 SGTC_927 2425-1185 123 µM 0.972685563646576 0.172907704688541 no 638 0.16535480117071 814 730375 SGTC_3140 9094243 49.47 µM 0.971513477185264 0.173189063042756 no 639 0.165646322584773 908 19291112 SGTC_1952 st077036 64.1 µM 0.970367710718184 0.173464384959292 no 640 0.165931618728271 881 2937007 SGTC_1006 4099-6547 255 µM 0.969813907513639 0.173597560894393 no 641 0.166069629643 826 3146833 SGTC_3079 9117512 49.47 µM 0.968397393485189 0.173938493317661 no 642 0.166422970362907 903 7185044 SGTC_1049 3226-0134 66 µM 0.966698663982958 0.174347911555616 no 643 0.166847347597612 864 5702385 SGTC_2051 5263410 176 µM 0.966489266534433 0.17439842170579 no 644 0.16689970763387 861 227584 SGTC_1850 st056238 17 µM 0.966126453198354 0.174485960326415 no 645 0.166990454551108 881 5393177 SGTC_2206 7254556 146.969 µM 0.96504365467983 0.174747380924344 no 646 0.167261473409018 824 4398905 SGTC_1442 4112-3290 3 µM 0.963277708706532 0.175174267272351 no 647 0.16770408841694 866 704353 SGTC_713 1488-1073 324 µM 0.959329278900109 0.176131120975783 no 648 0.168696444974172 852 3312542 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.958203317168639 0.176404589155323 no 649 0.168980122430975 885 6708561 SGTC_1943 st076331 65.2 µM 0.951312475540883 0.178084051117349 no 650 0.17072288789925 877 24208415 SGTC_1643 st009866 20.2 µM 0.950951190131013 0.178172382187861 no 651 0.170814577029805 864 3156273 YOR207C RET1 SGTC_2012 4023501 200 µM 0.947628615957034 0.178986016422662 no 652 0.171659276473714 778 3477460 SGTC_1920 st075728 45.7 µM 0.947558179482632 0.179003290223552 no 653 0.171677212405702 858 3400306 SGTC_2414 st077232 92.9 µM 0.946515192562603 0.179259194497853 no 654 0.171942938520305 783 729801 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.944985665334468 0.17963489077308 no 655 0.172333097183461 781 6857784 SGTC_3168 9103419 49.47 µM 0.943147851042466 0.180086965220784 no 656 0.172802641501945 798 16649256 SGTC_90 0870-0863 4.608 µM 0.940237588290364 0.180804305338395 no 657 0.173547852566672 889 1738164 SGTC_2423 st077119 87.2 µM 0.938347595802107 0.181271120699304 no 658 0.174032903690877 835 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2555 cholic acid 100 µM 0.938122339758911 0.181326807714688 no 659 0.17409077124005 865 6708657 Influences liver metabolism. SGTC_1465 k213-0056 144 µM 0.937415213261625 0.181501690652768 no 660 0.174272509204938 838 24048857 YMR208W ERG12 SGTC_2552 juarezic acid 87.02 µM 0.937088906635098 0.181582426740213 no 661 0.174356413622584 1027 1549512 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.936998915914371 0.181604696556747 no 662 0.174379557780316 913 5106787 A p450 inhibitor. SGTC_665 3914-0008 307 µM 0.936714191895468 0.181675167875938 no 663 0.174452797048042 845 1069549 SGTC_2864 9034755 47.6 µM 0.936414399651414 0.181749387183706 no 664 0.174529933413941 929 4930451 SGTC_649 1123-0311 367 µM 0.936302655200184 0.18177705651358 no 665 0.174558690735554 908 693629 YIL048W NEO1 SGTC_1086 cerivastatin 2.18 µM 0.936133458527514 0.181818956750582 no 666 0.174602239055439 852 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1679 SEC14.276 6.7 µM 0.935432977501031 0.181992489688703 no 667 0.17478260424535 908 1005053 YMR079W SEC14 SGTC_2138 5575593 77.673 µM 0.934742721022256 0.182163590930255 no 668 0.174960452388585 863 762213 SGTC_3308 9128332 17.569 µM 0.933805876177558 0.182395977449199 no 669 0.175202018915967 937 17332805 YDL196W YDL196W SGTC_3309 9129340 25.759 µM 0.932489972726557 0.182722702954562 no 670 0.175541683181931 927 17158987 SGTC_2556 citropten 84.59 µM 0.932180649672259 0.18279955774622 no 671 0.175621586958188 945 2775 A potential DNA crosslinker. SGTC_1445 4239-0156 97.7 µM 0.932000815452842 0.1828442488551 no 672 0.175668052003817 961 4008346 SGTC_1936 st074407 74.3 µM 0.931771852235658 0.182901159017664 no 673 0.175727222128501 905 809813 SGTC_611 3453-1652 23.7 µM 0.931595168701031 0.182945082311555 no 674 0.175772890436456 914 1560575 SGTC_1511 0906-3109 28.5 µM 0.930820782942733 0.183137671228537 no 675 0.175973138609298 958 2882180 SGTC_32 0928-0142 34.1 µM 0.930552831963202 0.183204339792773 no 676 0.176042461596108 867 2244242 SGTC_1905 st060207 84.5 µM 0.929577612776903 0.183447110693079 no 677 0.17629491155708 873 1948547 SGTC_1522 st012842 45.6 µM 0.929136935448963 0.183556878586714 no 678 0.176409062532634 781 3491067 YOR116C RPO31 SGTC_51 1013-0126 23.419 µM 0.928575323328905 0.183696829323862 no 679 0.176554607638455 848 1627850 SGTC_3035 9091303 49.47 µM 0.926574043231274 0.184196077960944 no 680 0.177073868484572 895 25237002 SGTC_770 0389-1121 67.2 µM 0.922579444186933 0.185195111324991 no 681 0.178113205996682 943 6753108 SGTC_1625 st003711 30.1 µM 0.922415438445712 0.185236200300073 no 682 0.178155959970107 881 24207034 YER133W GLC7 SGTC_960 1222-0186 7.7 µM 0.918158498493336 0.186304687263419 no 683 0.179267946275185 892 3126296 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.917899372594819 0.18636985062658 no 684 0.179335775079108 921 688751 SGTC_2303 7774051 200 µM 0.917880332843486 0.18637463918116 no 685 0.179340759561401 853 2953184 SGTC_2235 salicylic acid 500 µM 0.912267465337767 0.187789614017554 no 686 0.180813968338899 895 338 A COX inhibitor and kinase inhibitor. SGTC_2133 5320837 200 µM 0.908972693306843 0.188623291004405 no 687 0.181682269994081 833 2841355 SGTC_1387 3342-1166 1.8 µM 0.908824123926329 0.188660937237288 no 688 0.181721485230915 841 3418228 SGTC_2222 6885208 172.143 µM 0.908366700589047 0.188776873548648 no 689 0.181842256444091 889 609514 SGTC_3083 9117465 49.47 µM 0.906892046178079 0.189150931193418 no 690 0.182231943834555 911 16420915 SGTC_1513 0337-0559 19 µM 0.906443115638777 0.189264896505734 no 691 0.182350680315179 834 775073 SGTC_8 0354-0001 70 µM 0.906064584165543 0.189361023184016 no 692 0.182450834682349 977 4993152 SGTC_2058 5236698 133 µM 0.903707158901372 0.189960358792997 no 693 0.183075351036797 877 766665 SGTC_2990 9074105 71.4286 µM 0.902624120148935 0.190236093609158 no 694 0.183362710351535 898 6502001 SGTC_1433 4060-0023 7.6 µM 0.902283118540221 0.190322961334571 no 695 0.183453245430934 919 3840627 SGTC_2962 9082311 13.18 µM 0.900541059504019 0.190767118501824 no 696 0.183916192447609 860 16459453 SGTC_2244 6635614 200 µM 0.893271763795222 0.192627361022962 no 697 0.185855827602831 778 836499 SGTC_2022 5136654 200 µM 0.892758016917206 0.192759249064037 no 698 0.185993386800961 891 1713771 SGTC_1608 st001473 40.5 µM 0.892705325818884 0.192772778933133 no 699 0.186007498766781 869 7292267 SGTC_692 k241-0027 77.8 µM 0.891969341884593 0.192961823424257 no 700 0.186204682666338 913 3600480 SGTC_2654 protoveratrine a 100 µM 0.891886879394302 0.192983011752303 no 701 0.186226783981498 932 5702278 A heart drug and vasodilator. SGTC_1812 st052057 4.327 µM 0.891504591493608 0.193081257292989 no 702 0.186329264714964 961 3645418 SGTC_1739 st037196 92.5 µM 0.889310240189388 0.193645782018376 no 703 0.186918184797169 970 612214 SGTC_1896 st058441 89 µM 0.889171940145382 0.193681395144373 no 704 0.186955340310419 839 688759 SGTC_1119 parthenolide 318.541 nM 0.888927138576147 0.19374444286894 no 705 0.187021119589782 976 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1174 0739-0097 51.1 µM 0.888679100896479 0.193808336801599 no 706 0.187087783027482 914 728447 SGTC_2712 st079126 47.7 µM 0.888108756828443 0.193955304831287 no 707 0.187241126355953 880 3152970 SGTC_1037 k284-1091 78.7 µM 0.887144075771403 0.194204041370497 no 708 0.187500668389112 866 3334711 SGTC_3239 9133757 49.47 µM 0.885502070491434 0.194627867945976 no 709 0.187942951700753 946 17036923 SGTC_1557 sumaresinolic acid 42.3 µM 0.884511881883565 0.194883722526059 no 710 0.188209975615297 868 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_257 daunorubicin 18.5 µM 0.882968316652053 0.195282971666936 no 711 0.188626695088236 936 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3288 9119690 36.221 µM 0.880988025443598 0.195795908837483 no 712 0.189162150633601 856 17595618 YKL019W RAM2 SGTC_886 0866-0150 153 µM 0.878316816473215 0.196489102242533 no 713 0.189885906153384 998 271463 SGTC_1286 0929-0070 131 µM 0.877925824083165 0.196590691542732 no 714 0.189991986949978 956 1420408 SGTC_543 3844-1095 191 µM 0.876884098664542 0.196861512348012 no 715 0.190274796979102 945 4230703 SGTC_1316 1272-0050 65.9 µM 0.873314092684608 0.1977913307949 no 716 0.191245950613487 934 7340392 SGTC_609 0986-0026 86.3 µM 0.872344013006414 0.198044448634081 no 717 0.191510366817031 934 2848610 SGTC_2511 berberine 10.47 µM 0.868459265906345 0.199060033997636 no 718 0.19257148123396 919 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_390 dec-rvkr-cmk 16.7 µM 0.867356953014111 0.199348781024868 no 719 0.192873230096893 980 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_349 k015-0014 24 µM 0.866621209616689 0.199541646712202 no 720 0.193074794276677 890 2196908 SGTC_2269 7935389 174.42 µM 0.865582139020618 0.199814216947553 no 721 0.193359676925052 910 97605 SGTC_2591 skatole 100 µM 0.864096730923652 0.200204259647727 no 722 0.193767377347393 947 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_495 decylubiquinone 155 µM 0.863383100458464 0.20039180937647 no 723 0.19396343395131 889 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1884 5633444 25 µM 0.863014555235334 0.200488708321276 no 724 0.194064732165629 951 5724239 SGTC_2333 9017922 200 µM 0.861613567897462 0.200857316575153 no 725 0.194450101114367 973 3163164 SGTC_1492 4158-0558 28.5 µM 0.861353265010173 0.200925848613772 no 726 0.194521753792513 951 3967268 SGTC_233 rapamycin 362 pM 0.861292336236092 0.200941891849101 no 727 0.194538527766659 1022 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_710 3448-4187 58 µM 0.857434213315345 0.20195934368685 no 728 0.19560247889817 1028 3946412 SGTC_1902 st060212 70.5 µM 0.856534387531266 0.202197085599888 no 729 0.195851130215628 1014 688944 SGTC_364 0083-0097 67.7 µM 0.855934188336964 0.202355756569313 no 730 0.196017091490211 947 5207356 SGTC_3113 9123498 49.47 µM 0.855156212349361 0.202561536075613 no 731 0.196232336793777 1033 8897275 SGTC_1717 st033143 58.0435 µM 0.854545286499701 0.202723217426868 no 732 0.196401464172882 977 674616 SGTC_2197 6588183 93.1375 µM 0.853573201315711 0.202980638405468 no 733 0.196670756174452 943 884136 SGTC_2528 xanthyletin 44.79 µM 0.851905369191005 0.203422756867161 no 734 0.197133308285924 958 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1554 st069299 38.7 µM 0.850976182729523 0.203669319921617 no 735 0.197391291672602 979 24207999 SGTC_252 miconazole 1.30953 nM 0.84890003574709 0.204220876662776 no 736 0.197968459487579 952 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_475 α-linolenic acid 10 µM 0.847643098452172 0.204555231028174 no 737 0.198318382247852 1052 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2092 5303694 80.6725 µM 0.845171405337778 0.205213668488782 no 738 0.199007572556479 960 1963699 SGTC_3223 9129970 49.47 µM 0.844219524939289 0.205467576602494 no 739 0.199273372952613 1018 17248386 SGTC_2924 9010168 62.78 µM 0.843954388239343 0.205538333354454 no 740 0.199347447028103 981 2993929 SGTC_973 1325-0077 65.9 µM 0.842434251911719 0.205944289699883 no 741 0.199772463704743 1035 2835149 SGTC_2148 5546263 113.568 µM 0.84033624925712 0.206505347211895 no 742 0.200359941175441 978 792097 SGTC_3211 9128781 49.47 µM 0.833980364814965 0.208210584628458 no 743 0.202146024285064 903 17194361 SGTC_2321 7390090 138.78 µM 0.832924111826798 0.208494772567204 no 744 0.202443765035688 922 649046 SGTC_2856 9022925 19.48 µM 0.830965969249537 0.209022221170572 no 745 0.202996427133804 976 4944862 SGTC_1150 3909-7983 10.9 µM 0.830937066301584 0.209030012398375 no 746 0.203004591383663 986 23965914 SGTC_1376 2910-0861 41.3 µM 0.830881440481346 0.209045007662867 no 747 0.203020304626653 1015 1112859 SGTC_2959 9079155 11 µM 0.830625081887049 0.209114123413801 no 748 0.203092730470779 952 16189457 SGTC_1125 tnp00248 1.32998 µM 0.825112578524216 0.210603578728544 no 749 0.204653839553657 1140 24207736 SGTC_1769 st044406 64.4 µM 0.824775447011303 0.210694871798059 no 750 0.204749544334468 994 670903 SGTC_2945 9067681 61.76 µM 0.824452413505292 0.210782368993207 no 751 0.204841271946814 1017 16456930 SGTC_2774 tamoxifen 10.92 µM 0.822321456446799 0.211360096044074 no 752 0.205446984091558 1033 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1355 1499-0035 1.68 µM 0.818658042766922 0.212355454671964 no 753 0.20649077060717 991 1548538 SGTC_3023 9089636 49.47 µM 0.818291501145291 0.212455195464052 no 754 0.206595378924998 1097 17249241 SGTC_2059 5238311 157 µM 0.814461323881639 0.213499073145107 no 755 0.207690360048739 994 703021 SGTC_2862 9027634 71.43 µM 0.811425610955763 0.214328546557013 no 756 0.208560648207104 960 5012562 SGTC_2824 7998404 51.95 µM 0.807738995004748 0.215338387672496 no 757 0.20962042516599 972 837851 SGTC_1405 3909-7894 12 µM 0.80747718524314 0.215410207673322 no 758 0.209695806839719 1045 7104060 SGTC_2105 5350118 200 µM 0.806578762201072 0.215656769911263 no 759 0.209954606805621 1036 2133313 SGTC_1276 0871-0068 94.2 µM 0.804795442694318 0.216146666616907 no 760 0.210468865977975 1010 3414906 SGTC_321 4534-3890 65.3 µM 0.804077017697863 0.216344207522968 no 761 0.21067624827718 1064 699746 SGTC_2387 9077560 195.08 µM 0.802570091056419 0.216758897194698 no 762 0.211111630616335 1008 5303272 SGTC_200 k038-0079 37.545 µM 0.801680207979689 0.21700399895982 no 763 0.21136898373822 1002 3436683 SGTC_3170 9103054 49.47 µM 0.799921058098334 0.217488995113565 no 764 0.211878268107582 992 16432970 SGTC_2572 astragaloside iv 100 µM 0.798337469142224 0.217926123932659 no 765 0.21233733993306 1013 45006101 An anti-inflammatory agent. SGTC_599 1935-0052 86.5 µM 0.795646827866086 0.2186700004102 no 766 0.213118670210711 1077 9557311 SGTC_1803 st050068 52.4 µM 0.794975329074086 0.218855876043263 no 767 0.213313926660395 1126 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2874 9043904 71.43 µM 0.794825407065825 0.21889738792959 no 768 0.213357534780887 948 4463428 SGTC_633 0437-0093 97.7 µM 0.791524163236931 0.219812616279719 no 769 0.214319090749259 1077 2831118 SGTC_2287 7945887 168.79 µM 0.791237071349678 0.219892312578871 no 770 0.214402831200901 1082 1245853 SGTC_2821 7996764 71.43 µM 0.786988928802711 0.221073527480214 no 771 0.215644173581756 1128 2987135 SGTC_153 4077-0274 519.67 µM 0.785596789441104 0.221461406500133 no 772 0.216051872989764 1029 3121976 SGTC_3206 9114350 49.47 µM 0.784517039512079 0.221762515036309 no 773 0.216368393807666 976 17087243 SGTC_1703 st026983 48.3 µM 0.784066258334835 0.221888292999856 no 774 0.216500616398346 1082 1104023 SGTC_2145 5634607 200 µM 0.783256377610546 0.222114370035344 no 775 0.216738287052313 1023 308662 SGTC_2390 9097792 176.6 µM 0.781999783096406 0.222465406705396 no 776 0.217107350531494 1004 4497149 SGTC_2894 9048625 32.47 µM 0.781958667945084 0.22247689779465 no 777 0.217119432237534 1090 4092861 SGTC_2449 5812982 45.77 µM 0.781871074187449 0.222501380109845 no 778 0.217145172998606 1010 776185 SGTC_1324 1418-0026 34.4 µM 0.781699996033966 0.222549200610354 no 779 0.217195452006147 1065 1372513 SGTC_130 0136-0219 337.655 µM 0.780619382056977 0.222851393849169 no 780 0.217513194368692 1046 234244 SGTC_526 4469-0568 170 µM 0.779274869618851 0.223227712379587 no 781 0.21790890744922 1062 2901964 SGTC_1755 st041960 45.185 µM 0.777354383839868 0.223765868183857 no 782 0.218474858742389 1058 2257073 SGTC_492 tmb-8 126 µM 0.775804434726264 0.224200730004601 no 783 0.218932232550336 956 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_161 4065-0411 162.148 µM 0.775449606295186 0.224300349986459 no 784 0.219037016143636 1065 1906281 YLR208W SEC13 SGTC_2681 menadione 3.18 µM 0.773732654908775 0.224782748120369 no 785 0.219544452478883 1097 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2911 7942208 15.64 µM 0.771293151183752 0.22546916668803 no 786 0.220266595478967 1051 1243384 SGTC_2280 7785178 200 µM 0.770454077276776 0.225705536169334 no 787 0.220515292950068 1048 2954328 SGTC_1456 k015-0012 13 µM 0.769797398618651 0.225890622142883 no 788 0.220710041536697 1159 2989616 SGTC_3088 9117578 49.47 µM 0.768787415683228 0.226175454954733 no 789 0.221009760354055 1147 678341 SGTC_2803 7707263 71.43 µM 0.768431658623704 0.226275832965854 no 790 0.221115388961157 1044 2199229 SGTC_271 rotenone 740 µM 0.767265185385414 0.226605133661953 no 791 0.221461931643792 1149 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_814 3342-0569 96 µM 0.765593004091363 0.227077669539847 no 792 0.221959254217546 1091 4346283 SGTC_521 r062-0005 13.8 µM 0.760432130422596 0.228539560544434 no 793 0.223498161788256 1046 2832033 SGTC_3051 9093778 49.47 µM 0.760201474205443 0.228605020388797 no 794 0.223567081967367 1078 17217378 SGTC_842 0271-0008 11.1 µM 0.759804788204276 0.228717623829111 no 795 0.22368564018441 1117 1221709 SGTC_1650 st011916 45.8 µM 0.758213676257423 0.22916959029932 no 796 0.22416153759318 1099 242528 SGTC_2444 5485484 36.41 µM 0.757389806400803 0.229403812974157 no 797 0.224408180678182 1126 6790631 SGTC_869 0564-0080 44.1 µM 0.757355190558914 0.229413657046187 no 798 0.224418547042362 1063 6843321 SGTC_1649 st011737 51.3 µM 0.756545802814143 0.229643898652333 no 799 0.224661010866181 1064 1761035 SGTC_2892 9047358 58.44 µM 0.756014778971361 0.22979502606327 no 800 0.224820167437738 1067 6466771 SGTC_1217 1183-1422 255 µM 0.754535041104837 0.230216447622327 no 801 0.225264006296835 1151 2849664 SGTC_2719 novobiocin 32.65 µM 0.75291428903843 0.230678524905179 no 802 0.225750710495292 1094 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3355 9151058 44.0485 µM 0.752511808930707 0.230793352459677 no 803 0.225871665506789 1133 17015728 SGTC_860 0443-0016 25.1 µM 0.75184564551043 0.230983478978763 no 804 0.226071944238759 1158 5337942 SGTC_1108 betulinic acid 729.144 nM 0.751638983726807 0.231042479095948 no 805 0.226134096473448 1132 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2966 9084041 48.03 µM 0.751359081021788 0.231122402260332 no 806 0.226218290849665 1069 17741380 SGTC_1228 0124-0032 52.5 µM 0.751329446209496 0.231130865060868 no 807 0.226227206000111 1146 X1228 SGTC_2980 9014342 25.29 µM 0.749840987453841 0.231556145974626 no 808 0.226675239861957 1080 2996599 SGTC_196 k015-0023 18.111 µM 0.74730808740589 0.232280845258653 no 809 0.227438805903628 1113 5211998 SGTC_3353 9151644 39.2805 µM 0.747184241408041 0.23231631171764 no 810 0.227476177534819 1105 4909158 SGTC_1945 st075991 56.6 µM 0.746865638280824 0.232407565689221 no 811 0.227572334753594 1066 1084980 SGTC_1410 3909-8106 77.9 µM 0.745730462604226 0.23273286352112 no 812 0.227915126720279 1135 1039210 SGTC_1496 4469-0713 57.4 µM 0.745710050198844 0.232738715249016 no 813 0.227921293365338 1095 746691 SGTC_116 0155-0182 31.788 µM 0.744839135316353 0.232988460994988 no 814 0.228184486625445 1120 771486 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.744411264921822 0.233111212689915 no 815 0.228313852994901 1118 803109 SGTC_1011 4112-3381 17.4 µM 0.742504695159145 0.233658624536621 no 816 0.228890804078421 1135 2877139 SGTC_1082 camptothecin 424.86 nM 0.742263273916189 0.23372799189258 no 817 0.228963919388076 1114 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_18 0111-0177 500 nM 0.742016708441093 0.233798849117523 no 818 0.22903860617239 1222 721752 SGTC_95 0471-0001 561.058 µM 0.741652697624564 0.233903479180589 no 819 0.229148893131033 1096 4015405 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.7405362259608 0.234224555857415 no 820 0.229487344235469 1286 16725076 SGTC_2433 5607874 27.82 µM 0.740465684702024 0.23424485041543 no 821 0.229508737762558 1141 2252428 SGTC_1248 0469-0687 58.6 µM 0.740447796954644 0.23424999683395 no 822 0.229514162878922 1122 4017482 SGTC_793 0488-0545 106 µM 0.740403598736327 0.234262713210438 no 823 0.229527567920032 1097 292548 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.740253124023106 0.234306009519739 no 824 0.229573209241405 1189 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_949 1165-0505 146 µM 0.739286670588427 0.234584194127984 no 825 0.229866470774955 1152 6244267 SGTC_531 3788-1495 174 µM 0.73814336727089 0.234913519067412 no 826 0.230213666441209 1063 2896655 SGTC_2365 9042475 200 µM 0.737917381868896 0.234978643682569 no 827 0.230282327860092 1156 6464479 SGTC_2816 7982706 58.44 µM 0.737152562539112 0.235199123790364 no 828 0.230514788791461 1115 2981853 SGTC_744 1594-0068 283 µM 0.737137698499077 0.235203409888165 no 829 0.230519307900552 1165 668392 SGTC_1104 tacrolimus 29.8 µM 0.73700307448381 0.235242231156888 no 830 0.230560239849662 1161 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3009 9080819 71.4286 µM 0.736976273211054 0.235249960210698 no 831 0.230568389165311 1160 17027216 SGTC_541 4513-1321 94 µM 0.735921668869132 0.235554202336063 no 832 0.230889184664627 1099 747515 SGTC_2326 6164455 177.58 µM 0.735490220885425 0.235678733027856 no 833 0.231020496747266 1097 2888790 SGTC_638 3970-0837 4.09 µM 0.732920125707714 0.236421302532798 no 834 0.231803573670636 1145 4118451 YLR208W SEC13 SGTC_337 1315-0038 354 µM 0.732289004980224 0.236603847015946 no 835 0.231996094414068 1106 1626437 SGTC_1841 st054148 70 µM 0.729597514971283 0.237383199688811 no 836 0.23281812082735 1097 675442 SGTC_1942 st076330 65.2 µM 0.728940620277129 0.237573625055961 no 837 0.23301899294895 1186 24208414 SGTC_2120 5538279 151.968 µM 0.728881311245642 0.237590822110507 no 838 0.233037133820056 1144 2058197 SGTC_2956 9076196 2.52 µM 0.728747615363114 0.237629590640763 no 839 0.233078030295843 1155 16423868 SGTC_341 1486-1430 230 µM 0.728725509035901 0.237636001268434 no 840 0.233084792824251 1136 2054753 YPL210C SRP72 SGTC_1044 1222-0021 1.78 µM 0.727834089002779 0.2378945837697 no 841 0.233357577145926 1082 4306703 SGTC_2731 amoxapine 43.43 µM 0.727495997291424 0.237992697517439 no 842 0.233461083235878 1167 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2071 5230951 39.92 µM 0.723840888586649 0.239054819934401 no 843 0.23458171174064 1209 1799272 SGTC_2801 7907800 81.82 µM 0.723137926225267 0.239259387445768 no 844 0.234797575258464 1190 6620925 SGTC_2612 dictamnine 15.46 µM 0.721112302893133 0.239849394090794 no 845 0.235420211081999 1103 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_400 oxethazaine 37.5 µM 0.719598449455955 0.24029085437271 no 846 0.235886133488749 1099 4621 A local anesthetic. SGTC_924 2046-0044 21.3 µM 0.71898328022117 0.240470372524065 no 847 0.236075610782136 1183 3623589 SGTC_474 dl-dihydrosphingosine 5 µM 0.718666595874329 0.240562815545087 no 848 0.23617318490713 1200 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2355 9061122 103.12 µM 0.718630600315716 0.240573324198226 no 849 0.236184276962526 1147 5302957 SGTC_2781 5567276 71.43 µM 0.716243914290249 0.24127065796924 no 850 0.236920375744981 1133 2853274 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.714305446120939 0.241837840380573 no 851 0.237519162655608 1165 616764 SGTC_1232 0279-0259 161 µM 0.711872629853616 0.242550688181719 no 852 0.238271826104258 1188 1560000 SGTC_97 0535-0701 19.132 µM 0.709435944962723 0.243265808670706 no 853 0.239026994171011 1138 2832013 YGL099W LSG1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.708614418006391 0.24350716778406 no 854 0.239281893288531 1154 442882 SGTC_2733 amorolfine 100 µM 0.706753529342775 0.244054362425507 no 855 0.239859828932707 1176 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2833 9001315 45.46 µM 0.706726523109485 0.244062308492652 no 856 0.23986822185223 1161 2989378 SGTC_1506 4226-2149 212 µM 0.706617895607636 0.244094271464934 no 857 0.239901982412866 1198 991114 SGTC_1391 3442-0225 151 µM 0.706530148843889 0.244120092057084 no 858 0.239929255298911 1136 5227075 SGTC_2250 alverine citrate 130 µM 0.706175734712647 0.244224397873964 no 859 0.240039429230869 1136 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_102 gallobenzophenone 83.616 µM 0.705851962523606 0.24431970661406 no 860 0.240140101847809 1195 70837 SGTC_1425 4048-4433 7.33 µM 0.705398545540999 0.244453212548647 no 861 0.240281124447133 1231 23734946 SGTC_2069 5228469 200 µM 0.705076631045195 0.244548022212396 no 862 0.240381274281269 1142 2835210 SGTC_1343 1487-0095 224 µM 0.705004820265424 0.244569174492558 no 863 0.240403618214829 1182 4560101 YGL055W OLE1 SGTC_3001 9076041 71.4286 µM 0.704796821211028 0.244630447376578 no 864 0.24046834353135 1201 16004211 SGTC_2181 6316240 54.2555 µM 0.704592547665563 0.244690630836101 no 865 0.240531918776765 1165 12779990 SGTC_3037 9091026 49.47 µM 0.704212715682392 0.244802558846372 no 866 0.240650156705006 1208 25236398 YIL048W NEO1 SGTC_3031 9088762 49.47 µM 0.703044871583062 0.24514686900774 no 867 0.24101389308569 1162 205253 SGTC_1725 st036284 20.55 µM 0.702326839602674 0.245358692322325 no 868 0.241237679448451 1205 707914 SGTC_1065 prochlorperazine maleate 2.48 µM 0.700555345349817 0.245881713164329 no 869 0.241790277163373 1234 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_382 3229-0966 23.2 µM 0.699813174916545 0.246101011331759 no 870 0.242021992904637 1197 5722370 SGTC_2838 9002687 71.43 µM 0.698569413218489 0.246468755896603 no 871 0.242410582163087 1181 6457060 SGTC_1476 4112-3294 3.34 µM 0.698225558589596 0.246570475751891 no 872 0.242518072496066 1209 704369 SGTC_1455 4262-0120 131 µM 0.697788519672114 0.246699794043498 no 873 0.242654729859534 1247 1529587 SGTC_1336 1486-0901 104 µM 0.69620698968137 0.247168066614592 no 874 0.243149605492388 1196 5006114 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.696191769500976 0.247172575440608 no 875 0.243154370679877 1221 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1837 st055472 66.5 µM 0.694809784142572 0.247582158025628 no 876 0.243587257873048 1250 676091 SGTC_2317 5986382 200 µM 0.692962182557059 0.248130302374661 no 877 0.24416664226739 1241 877883 SGTC_1353 1498-1206 8.11 µM 0.692233252817969 0.248346738361363 no 878 0.244395429625169 1248 6756808 SGTC_1651 st011928 86.1 µM 0.692188788855764 0.248359943989199 no 879 0.244409389155335 1200 720198 SGTC_3296 9122258 64.045 µM 0.692004437430121 0.248414699655101 no 880 0.244467271155779 1197 4730474 SGTC_179 1273-0063 6.77 µM 0.690593778756906 0.24883390337138 no 881 0.244910429088374 1180 3108139 SGTC_2889 9059656 51.95 µM 0.69049721958555 0.248862611507278 no 882 0.244940778918445 1259 3949838 SGTC_482 fipronil 114 µM 0.689474383093031 0.249166820609992 no 883 0.245262394235152 1226 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1501 4491-0275 38.4 µM 0.689340567600809 0.249206634255904 no 884 0.245304487260585 1186 5104718 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.688007156718357 0.249603543986486 no 885 0.245724137287732 1211 6708739 YPR165W RHO1 SGTC_1852 st056254 31.4 µM 0.687676355237585 0.249702063968122 no 886 0.245828306515131 1170 442583 SGTC_1710 st031758 61.5 µM 0.686434590624832 0.250072073060439 no 887 0.246219549003737 1222 5394341 SGTC_2782 7736369 71.43 µM 0.68610981276118 0.250168895214153 no 888 0.246321931744304 1258 2950836 YOL077C BRX1 SGTC_1986 st071812 45 µM 0.68488952197818 0.250532863586522 no 889 0.246706819209348 1167 11838594 SGTC_2242 6630449 61.2675 µM 0.683812691171806 0.250854275945472 no 890 0.247046725780882 1176 691249 YDR170C SEC7 SGTC_425 3825-7017 13.1 µM 0.682300536499336 0.251305991951899 no 891 0.247524466948376 1254 3397440 SGTC_2353 9059630 146.67 µM 0.67577957453185 0.253258871386888 no 892 0.249590302395666 1245 4779114 SGTC_365 0121-0052 13.6 µM 0.674490759476595 0.253645784308563 no 893 0.249999679274407 1238 3101739 SGTC_3222 9128301 49.47 µM 0.674490759476595 0.253645784308563 no 894 0.249999679274407 1251 4911358 SGTC_3333 9141820 12.094 µM 0.672177468409457 0.254341031325487 no 895 0.250735361615945 1219 1939433 SGTC_659 k018-0002 107 µM 0.67183098598134 0.254445250676701 no 896 0.25084565001321 1224 6797879 YHR007C ERG11 SGTC_2607 solasodine 47.35 µM 0.671499429956544 0.25454500122547 no 897 0.250951211245746 1250 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1285 0929-0069 65.5 µM 0.669667582741492 0.255096492117377 no 898 0.251534860618975 1236 1206237 SGTC_1190 1486-1332 13 µM 0.667148078144109 0.255856026921712 no 899 0.252338776292022 1226 4150046 SGTC_2005 4024620 188 µM 0.665940492791041 0.256220485954506 no 900 0.252724568483167 1251 236743 SGTC_1341 1486-1360 280 µM 0.665750705175373 0.256277789995839 no 901 0.252785228933116 1238 3976547 SGTC_1175 0741-0056 27.6 µM 0.66546204753541 0.256364959433868 no 902 0.252877505191837 1291 765927 SGTC_501 nsc-95397 161 µM 0.665260901123003 0.256425711182322 no 903 0.252941816892395 1270 262093 SGTC_2228 7354201 200 µM 0.663783607815148 0.256872124145058 no 904 0.253414409323415 1266 753451 SGTC_3019 9081971 49.47 µM 0.66370561250039 0.256895704240083 no 905 0.253439373248111 1292 16451803 SGTC_1545 lovastatin 49.4 µM 0.663597718040086 0.256928325512888 no 906 0.253473909108993 1289 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_709 3807-1509 243 µM 0.662622319882984 0.257223329351085 no 907 0.253786235807277 1282 1886677 YPL242C IQG1 SGTC_3285 9112818 20.8695 µM 0.660877678830271 0.257751425320018 no 908 0.254345380889148 1283 17017947 YPR165W RHO1 SGTC_2356 9061756 188.97 µM 0.660661573667066 0.257816878652012 no 909 0.254414685980523 1222 20104043 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.660199414570374 0.257956885060193 no 910 0.254562933964641 1239 6312947 SGTC_2081 5214970 32.255 µM 0.660134306354791 0.257976612102504 no 911 0.254583822533516 1210 2063512 SGTC_808 0711-0032 135 µM 0.659065446281496 0.258300576283034 no 912 0.254926871586648 1232 4252555 SGTC_3210 9128157 49.47 µM 0.658866375776098 0.258360936474353 no 913 0.254990789681152 1247 17590849 SGTC_2896 9052656 71.43 µM 0.658054333913255 0.258607231474314 no 914 0.255251609110377 1230 6469436 SGTC_749 1000-0129 128 µM 0.657925304055196 0.258646377850083 no 915 0.25529306500164 1313 708470 SGTC_1570 verbenone 133 µM 0.657011058118454 0.25892383883032 no 916 0.255586903078051 1274 29025 A natural terpanoid with antifungal properties. SGTC_1294 1000-1494 117 µM 0.656313726540009 0.259135572769227 no 917 0.255811143710321 1233 712797 YDL207W GLE1 SGTC_1622 st003707 19.4 µM 0.656243876824535 0.259156786485195 no 918 0.255833610912082 1294 10140899 SGTC_748 act1.228 77.9 µM 0.654792936468256 0.259597647418863 no 919 0.25630053952032 1218 4421505 YNR035C ARC35 SGTC_2560 caryophyllene 100 µM 0.653382427621759 0.260026594306517 no 920 0.256754882272419 1295 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2757 clomiphene 4.22 µM 0.651283341558126 0.260665618939714 no 921 0.257431799895634 1313 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2999 9069765 71.4286 µM 0.647049903732346 0.261956858553325 no 922 0.258799823085219 1290 2097066 SGTC_707 0865-0008 204 µM 0.647018213282754 0.261966536800025 no 923 0.258810077930365 1292 723043 SGTC_1726 st035556 14.5795 µM 0.64692308264155 0.261995590749139 no 924 0.258840862915467 1348 5919439 SGTC_2635 hydroquinidine 100 µM 0.646832212304644 0.262023345096791 no 925 0.258870271003581 1285 442912 An experimental heart treatment. SGTC_2109 5483026 200 µM 0.644096548684809 0.262859598533579 no 926 0.259756414127399 1299 759335 SGTC_598 3937-0236 20.2 µM 0.642258043514756 0.263422369198517 no 927 0.260352825695918 1305 1379313 SGTC_2328 6201408 200 µM 0.64025675932651 0.264035665306658 no 928 0.261002843782953 1255 2890418 SGTC_1644 st010134 20.9 µM 0.639959563715834 0.264126803290563 no 929 0.261099444173024 1271 3818134 SGTC_2441 5730946 39.09 µM 0.639831309008873 0.264166138819074 no 930 0.261141137728273 1305 1774275 SGTC_1977 st070720 65.3 µM 0.639792404886592 0.264178071245519 no 931 0.261153785512967 1281 682188 SGTC_2268 7933382 153.85 µM 0.638900522083504 0.264451699168238 no 932 0.261443824175824 1307 935025 YOR257W CDC31 SGTC_3292 9120825 59.784 µM 0.638825535858227 0.264474711368993 no 933 0.261468217095561 1294 24824900 SGTC_1295 1013-0063 9.78 µM 0.63687192372688 0.265074605908812 no 934 0.262104136087776 1290 6826038 SGTC_2507 purpurin 79.67 µM 0.634475674350474 0.265811363496292 no 935 0.262885218580659 1270 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3273 9137859 49.47 µM 0.633234122763065 0.266193502229039 no 936 0.263290382842118 1349 2377234 SGTC_2111 5486399 200 µM 0.633212299645961 0.26620022168035 no 937 0.263297507384342 1294 689674 SGTC_180 1486-1293 102.781 µM 0.631216642393704 0.266815057679286 no 938 0.263949440858561 1351 4140536 SGTC_714 4296-0578 26.1 µM 0.629723323068847 0.26727559881905 no 939 0.264437810151393 1291 1589775 SGTC_2007 4011539 71.82 µM 0.62645180167756 0.268285939227029 no 940 0.265509320654092 1335 45595301 SGTC_314 1671-0008 2.74 µM 0.625940091969428 0.268444143565409 no 941 0.265677118216339 1234 3913060 SGTC_2721 ifenprodil 61.44 µM 0.625243105107692 0.2686597051287 no 942 0.265905757502312 1310 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3332 9141069 11.198 µM 0.62466654007058 0.268838088778432 no 943 0.26609496898401 1268 17332883 SGTC_876 0720-0963 56.8 µM 0.624478559832607 0.26889626090259 no 944 0.266156673237758 1361 765861 SGTC_2568 diosmetin 100 µM 0.624115217833341 0.269008718165013 no 945 0.266275960278795 1304 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_177 1327-0068 8.361 µM 0.623853244144511 0.269089815766598 no 946 0.266361984369301 1305 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2140 5586273 200 µM 0.623732591884285 0.26912716947887 no 947 0.266401607584535 1301 854421 SGTC_922 1866-0035 480 µM 0.622566819982741 0.269488224225925 no 948 0.26678461041415 1311 3156169 SGTC_417 st075190 100 µM 0.621785301403851 0.269730406568062 no 949 0.267041526328258 1343 222757 SGTC_2165 5727197 32.143 µM 0.620685990084968 0.270071253104857 no 950 0.267403124568197 1428 1361712 SGTC_450 aminopyrene 156 nM 0.61994800387048 0.270300189953269 no 951 0.267646010036733 1306 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3025 9087895 49.47 µM 0.618663235372572 0.270698980032176 no 952 0.268069117214792 1313 17173641 SGTC_292 k038-0015 474 µM 0.617586181245836 0.271033522131916 no 953 0.268424077990448 1309 46368540 SGTC_3046 9092212 49.47 µM 0.616553841896751 0.271354368894072 no 954 0.268764523968532 1331 25236637 SGTC_3169 9102970 49.47 µM 0.616190598384373 0.271467308460234 no 955 0.268884366368843 1374 17027839 SGTC_2194 5927483 104.545 µM 0.614108443916173 0.272115142771418 no 956 0.269571834398723 1329 760979 SGTC_2270 7924575 90.91 µM 0.610169010080372 0.273342943448238 no 957 0.270874928049044 1343 1262135 SGTC_2053 5265679 138 µM 0.608308677755899 0.273923704163089 no 958 0.271491383347548 1300 764595 SGTC_1173 0443-0020 122 µM 0.607365382483924 0.274218416058277 no 959 0.271804228350375 1326 5331295 SGTC_636 0kpi-0074 126 µM 0.605252022410529 0.274879256903307 no 960 0.272505777274652 1303 616434 SGTC_2823 7987624 58.44 µM 0.604514644235375 0.275110017231465 no 961 0.272750768015482 1363 2239440 SGTC_664 1222-0054 14.9 µM 0.603938318267693 0.275290443144803 no 962 0.272942325904302 1318 6813991 SGTC_2723 salbutamol 83.58 µM 0.603338096611386 0.27547841178908 no 963 0.27314189707712 1332 9884233 β2-adrenoceptor agonist SGTC_2624 nerol 100 µM 0.60245854147703 0.27575397200082 no 964 0.273434476015549 1323 637566 A natural product oil. SGTC_1349 flufenamic acid 69 µM 0.602234561517862 0.275824165433725 no 965 0.273509006435331 1305 3371 A non-steroidal anti-inflammatory. SGTC_3253 9135987 49.47 µM 0.600914412257763 0.276238067378992 no 966 0.273948496703465 1340 4182430 SGTC_1516 st013856 110 µM 0.599974080547828 0.276533072156406 no 967 0.27426175481639 1319 5281404 A mutagen and neurotoxin. SGTC_1357 1503-1303 39.5 µM 0.59942410850776 0.276705683228773 no 968 0.274445052111376 1345 292895 SGTC_381 3461-2219 42.7 µM 0.599020345560432 0.276832439550124 no 969 0.274579658619208 1352 2883159 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.59865112804976 0.276948375652698 no 970 0.274702776868944 1306 688662 SGTC_2448 5185112 27.17 µM 0.598618920265225 0.276958490181609 no 971 0.274713518078451 1318 5718189 SGTC_829 1635-0120 117 µM 0.598063850948434 0.277132832495598 no 972 0.274898664735671 1371 285054 SGTC_3323 9138564 53.9225 µM 0.596622219756041 0.277585886672178 no 973 0.275379816425625 1363 43912313 YNL103W MET4 SGTC_486 niguldipine 82 µM 0.59583248992676 0.277834224414728 no 974 0.275643568307394 1351 1236 A calcium channel blocker. SGTC_3163 9099914 49.47 µM 0.59578167081391 0.277850208661689 no 975 0.275660544992684 1371 16268368 SGTC_2399 5884133 200 µM 0.592188338158686 0.278981564164813 no 976 0.276862238855615 1337 722445 SGTC_342 k048-0088 23.3 µM 0.592077144202751 0.27901660912919 no 977 0.276899465580049 1327 6820570 SGTC_1518 st038567 90.8 µM 0.590706717300208 0.279448701862822 no 978 0.277358473188473 1329 77966 SGTC_642 0335-0876 158 µM 0.589966081399525 0.279682358013427 no 979 0.277606694829818 1370 6812350 SGTC_1159 4092-0538 61.2 µM 0.589673195719066 0.27977478387427 no 980 0.277704884422141 1393 717301 SGTC_2314 7727897 200 µM 0.58724548589448 0.280541465606012 no 981 0.278519423774233 1335 900724 SGTC_1153 4055-0057 267 µM 0.586279986414714 0.28084665704306 no 982 0.278843688990639 1327 882706 SGTC_71 0417-1750 47.813 µM 0.585828406038332 0.280989455294463 no 983 0.278995416328258 1435 6811472 SGTC_1831 st055328 12 µM 0.584583604522408 0.281383266626159 no 984 0.279413867312782 1382 1103068 SGTC_1628 st004252 77.7 µM 0.584417040404714 0.281435981842168 no 985 0.279469882422969 1426 692968 SGTC_921 1561-0023 372 µM 0.582775711760978 0.281955694109075 no 986 0.280022148729403 1358 24050882 SGTC_2469 5655019 90.81 µM 0.580241640359567 0.282758992223654 no 987 0.280875838325734 1464 2788239 SGTC_704 1310-0270 142 µM 0.579037418216594 0.283141114467034 no 988 0.281281962738359 1330 5718033 SGTC_2208 7283366 200 µM 0.577551909249884 0.283612835372694 no 989 0.28178334147537 1407 898663 SGTC_2234 tolnaftate 200 µM 0.576625513092772 0.283907201418089 no 990 0.282096230230136 1356 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_838 0109-0203 71.4 µM 0.574917161326139 0.284450420094659 no 991 0.282673661472596 1372 759422 SGTC_1964 st076914 61 µM 0.574602634169565 0.284550486984253 no 992 0.282780035071427 1369 24208661 SGTC_480 am 92016 50 µM 0.574514220197867 0.284578618937215 no 993 0.282809940283484 1303 2129 K+ channel blocker. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.574343790179793 0.284632850869971 no 994 0.282867590954508 1427 688664 SGTC_13 0199-0087 65 µM 0.573849884666131 0.284790042659372 no 995 0.283034694240731 1395 4589825 SGTC_1259 0671-0132 43 µM 0.573583076067652 0.284874975161414 no 996 0.283124983427607 1359 X1259 SGTC_933 2914-0560 114 µM 0.573011833925321 0.285056857838684 no 997 0.283318340705546 1441 463887 SGTC_2200 6600604 21.907 µM 0.572605364734564 0.285186310749392 no 998 0.283455963249789 1337 2904777 SGTC_3317 9138495 8.753 µM 0.568573290416412 0.286471966727787 no 999 0.284822877575072 1373 17020139 SGTC_3201 9113999 49.47 µM 0.568436400686316 0.28651566323222 no 1000 0.284869339738817 1454 16649224 SGTC_3227 9130768 49.47 µM 0.568094236631174 0.286624899082767 no 1001 0.284985490503496 1410 17720899 SGTC_2045 5106652 78.05 µM 0.566694312456276 0.287072030372837 no 1002 0.285460942837675 1398 673349 SGTC_1397 3532-0190 20.1 µM 0.565753158482556 0.287372817487725 no 1003 0.285780796484138 1383 5322280 SGTC_2973 9094665 17.96 µM 0.564077610180328 0.28790868126017 no 1004 0.286350657458659 1505 25237061 YIL048W NEO1 SGTC_2023 5144124 124 µM 0.562345099759151 0.288463257982588 no 1005 0.286940458116871 1380 2830192 SGTC_1572 epiandrosterone 68.9 µM 0.561526546699798 0.288725451894261 no 1006 0.287219319195792 1354 441302 A steroid. SGTC_1194 1488-0194 225 µM 0.557910560452263 0.289885043230068 no 1007 0.288452729949584 1403 1391452 SGTC_2991 9074669 71.4286 µM 0.557819190969994 0.289914372294433 no 1008 0.288483928336356 1472 17333109 SGTC_1222 0366-0074 1.18 µM 0.557097404716155 0.290146110323025 no 1009 0.288730440323741 1452 286520 SGTC_2648 atorvastatin 78.68 µM 0.556508630144991 0.29033520763136 no 1010 0.288931598196351 1431 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2684 capsaicin 100 µM 0.554246651288104 0.291062225832805 no 1011 0.28970502765404 1387 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_422 cantharidin 155 µM 0.553365006833511 0.291345823588772 no 1012 0.290006747781738 1347 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_220 paclitaxel 373.376 µM 0.551279723304476 0.29201710747466 no 1013 0.290720968078435 1430 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1624 st003710 6.25 µM 0.550175953046202 0.292372718794589 no 1014 0.291099347692371 1492 24207033 SGTC_2960 9079389 5.97 µM 0.549434240131843 0.292611795994974 no 1015 0.291353740838328 1478 16457355 SGTC_2513 baicalein 25.65 µM 0.54903777840015 0.292739625211954 no 1016 0.291489762056077 1352 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1426 4048-4480 71.7 µM 0.548705391365078 0.292846815118351 no 1017 0.291603822841694 1455 14224343 SGTC_1135 dihydrocapsaicin 536.708 nM 0.546495298489955 0.293560000296176 no 1018 0.29236275931347 1350 107982 A Capsaicinoid. SGTC_2934 9036370 36.88 µM 0.545442700646807 0.293899950501443 no 1019 0.292724539527542 1495 6462800 SGTC_2473 5854593 8.94 µM 0.545335255358502 0.293934661597676 no 1020 0.292761480402847 1406 2872951 SGTC_2383 9036125 200 µM 0.544658044723878 0.29415348375705 no 1021 0.292994362692907 1420 79580 SGTC_672 1441-0018 53.7 µM 0.54426810194934 0.294279517277923 no 1022 0.293128496979866 1370 251141 SGTC_1951 sophoraflavanone G 9.2 µM 0.542871831170714 0.294731010790305 no 1023 0.293609025935136 1398 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2044 5102272 200 µM 0.542633922136059 0.294807972110078 no 1024 0.293690939083188 1415 592666 SGTC_353 1988-1175 58.3 µM 0.541738511236982 0.295097712075264 no 1025 0.293999327849235 1356 2788357 SGTC_1151 3909-8316 15.3 µM 0.541625342798402 0.29513434081879 no 1026 0.29403831488315 1424 800431 SGTC_255 tunicamycin 200.472 nM 0.538451212927037 0.296162549541499 no 1027 0.29513278905237 1435 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_398 bronopol 33.3 µM 0.537498791378981 0.296471391548411 no 1028 0.29546155977885 1436 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2293 7624732 200 µM 0.53492988924624 0.297305145206731 no 1029 0.296349169605849 1374 894453 SGTC_2291 7917025 104.35 µM 0.534730954189574 0.297369755526026 no 1030 0.296417956834571 1373 2964612 SGTC_499 genistein 192 µM 0.532596169109657 0.298063496429666 no 1031 0.297156577283367 1489 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1669 st015249 58.4 µM 0.531759175236643 0.298335695359227 no 1032 0.297446400650562 1484 722793 SGTC_1389 3405-0187 19 µM 0.530177184784861 0.298850483572904 no 1033 0.297994544033597 1378 799890 SGTC_3282 9108498 15.4605 µM 0.52860048084962 0.299363952737512 no 1034 0.298541313331282 1413 16459645 SGTC_2188 6126565 140.678 µM 0.526862348041859 0.299930455984203 no 1035 0.299144591181329 1464 874518 SGTC_1991 st073000 8.92 µM 0.525828863901936 0.300267525518324 no 1036 0.299503558955592 1492 4301969 YIL048W NEO1 SGTC_1303 1160-0052 261 µM 0.524439516285913 0.300720929086276 no 1037 0.299986438882736 1449 3562476 SGTC_544 k015-0020 52.4 µM 0.523127994833267 0.301149217906831 no 1038 0.300442592603663 1454 3008304 SGTC_547 1120-0019 610 nM 0.521716456461178 0.301610474943454 no 1039 0.300933882487403 1458 3676939 SGTC_1033 k072-0102 21.3 µM 0.520708596385169 0.301940013874688 no 1040 0.301284892522343 1542 5965931 SGTC_868 0527-0199 213 µM 0.519837813445538 0.302224863020849 no 1041 0.301588310730083 1471 2849450 SGTC_2933 9026794 32.47 µM 0.519327866207704 0.302391732130872 no 1042 0.301766062061724 1509 17586027 SGTC_852 0418-0143 439 µM 0.516367818055162 0.303361158259432 no 1043 0.302798769094515 1473 5369229 SGTC_2676 harmalol 100 µM 0.515764628913873 0.303558875033589 no 1044 0.30300940479364 1508 5459187 A monoamine oxidase inhibitor SGTC_37 0566-0070 1.56 µM 0.514484470307485 0.303978683248329 no 1045 0.303456657613075 1538 1626686 SGTC_195 4234-0266 16.654 µM 0.513288920966606 0.304370978745304 no 1046 0.303874616350437 1443 2303354 SGTC_125 0133-0007 11.75 µM 0.512006805068767 0.304791929588623 no 1047 0.304323123462089 1541 26541 SGTC_1471 k673-0312 37 µM 0.511579208187052 0.304932377902931 no 1048 0.304472770031051 1450 24099884 SGTC_1941 st076221 61.8 µM 0.510562023558195 0.305266597479005 no 1049 0.304828886832124 1454 2828568 SGTC_1418 3966-3099 2.4 µM 0.510247252811311 0.305370055621318 no 1050 0.304939125707167 1529 740335 SGTC_2657 nystatin 74.44 µM 0.510092550268935 0.305420908604613 no 1051 0.304993312055097 1497 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.510060754231672 0.305431360891272 no 1052 0.305004449513288 1528 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2070 5230947 200 µM 0.509540483684201 0.305602411550161 no 1053 0.305186714588153 1532 2835538 SGTC_3094 9117742 49.47 µM 0.507924312051096 0.306134034892565 no 1054 0.305753211994374 1408 17149698 SGTC_841 0251-0215 91.2 µM 0.506703833459962 0.306535769831359 no 1055 0.30618132020197 1502 3888614 SGTC_2566 crystal violet carbinol 226 nM 0.506205378834163 0.306699908980104 no 1056 0.3063562397056 1376 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1070 indatraline 8.81 µM 0.505656401683276 0.306880729863938 no 1057 0.306548939834768 1441 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3189 9110682 49.47 µM 0.50524185151466 0.307017304629612 no 1058 0.306694489308284 1491 17122418 SGTC_2882 9058044 58.44 µM 0.504474592401648 0.3072701510349 no 1059 0.306963956085552 1394 18076804 SGTC_2629 bisabolol 100 µM 0.504034550779676 0.307415205911893 no 1060 0.307118548866824 1546 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2253 7938677 135.83 µM 0.502656510626069 0.307869656497291 no 1061 0.307602895403928 1580 2301972 SGTC_1127 asiatic acid 681.4 nM 0.502634188205618 0.3078770204219 no 1062 0.307610743938753 1446 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_596 1155-0152 116 µM 0.502172669000428 0.308029287940366 no 1063 0.307773033235566 1463 280313 SGTC_44 0929-0055 61.211 µM 0.501988083771989 0.308090196794527 no 1064 0.307837951591195 1420 1379590 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.501911656101314 0.308115417704861 no 1065 0.307864832852628 1452 689007 SGTC_2179 6298986 200 µM 0.501009271105493 0.30841327062645 no 1066 0.308182299065575 1572 738374 SGTC_245 methotrexate 289.6 µM 0.499291126442618 0.308980732435115 no 1067 0.308787152739278 1506 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.499169716448939 0.309020848504566 no 1068 0.308829913426386 1471 4620898 SGTC_2832 7992762 51.95 µM 0.499021844721692 0.309069711088484 no 1069 0.308881997455413 1344 2985177 SGTC_1695 st026914 34.495 µM 0.498181721387831 0.309347384690626 no 1070 0.309177982309015 1440 3289191 SGTC_681 1642-0006 26.6 µM 0.497927668326356 0.309431374564072 no 1071 0.30926751245309 1461 4446530 SGTC_655 k060-0012 42 µM 0.497585447518194 0.309544528408696 no 1072 0.309388131455115 1440 5994525 SGTC_3002 9075603 71.4286 µM 0.497523371196663 0.30956505561359 no 1073 0.30941001305054 1471 20105405 SGTC_202 3594-0513 34.79 µM 0.49437415220677 0.310607207968742 no 1074 0.310520982542687 1491 708429 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.493595078965278 0.310865257172052 no 1075 0.310796088441132 1456 5355888 SGTC_721 1187-1332 279 µM 0.493453778722074 0.310912069438056 no 1076 0.31084599564189 1435 25730 SGTC_3156 9099931 49.47 µM 0.489851712923552 0.31210645261792 no 1077 0.312119417125377 1550 18111053 SGTC_2586 curcumin 80 µM 0.486801649220623 0.313119348626328 no 1078 0.313199450749925 1573 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3143 9086658 49.47 µM 0.485193000909596 0.313654134038166 no 1079 0.313769723201265 1516 25236626 SGTC_262 fenpropimorph 62.5 µM 0.484260901070236 0.31396418437972 no 1080 0.314100360256305 1467 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1331 1472-0049 76.2 µM 0.484029651315856 0.314041126816581 no 1081 0.314182412934262 1459 24051409 SGTC_2061 5245884 80.95 µM 0.483228258401713 0.314307832333601 no 1082 0.314466836432842 1482 573863 SGTC_874 0599-0792 117 µM 0.47863638400188 0.315837885588206 no 1083 0.316098664906918 1633 765305 SGTC_1315 1237-0019 3.69 µM 0.478621414013604 0.315842878904015 no 1084 0.316103990723617 1575 825140 SGTC_1238 0333-0287 48.8 µM 0.478463146117099 0.3158956720224 no 1085 0.316160299434951 1493 7226 SGTC_1156 4092-0367 4.88 µM 0.477784669827657 0.316122032602046 no 1086 0.316401736719829 1533 1357585 SGTC_2429 5902844 64.44 µM 0.476459179694254 0.316564455772437 no 1087 0.316873641074543 1615 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_794 k038-0031 316 µM 0.475065719852704 0.317029849074627 no 1088 0.317370065609553 1495 6624242 SGTC_1040 k898-0338 155 µM 0.474724106174629 0.317143986807824 no 1089 0.317491816780085 1686 20969351 SGTC_1621 st003705 32.4 µM 0.473257851071795 0.317634079871661 no 1090 0.318014614465047 1612 24207032 SGTC_2394 5221648 200 µM 0.469866037617901 0.318769011539936 no 1091 0.319225365044481 1673 788586 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.46930140429759 0.31895810850935 no 1092 0.31942710581335 1635 165506 SGTC_938 3126-1755 342 µM 0.468385324682169 0.319265005884553 no 1093 0.319754530369814 1546 1777771 SGTC_3033 9090887 49.47 µM 0.467588217287585 0.319532146983145 no 1094 0.320039546294689 1477 19325384 SGTC_1999 st074831 12.5 µM 0.46670105358167 0.319829579541512 no 1095 0.320356887931619 1491 17112523 SGTC_1993 st073995 70.8 µM 0.466309259194202 0.319960970335408 no 1096 0.32049707603435 1552 3098394 SGTC_415 dibenzyl ketone 100 µM 0.462641417573669 0.321192098538233 no 1097 0.321810707918759 1634 7593 SGTC_2297 7971671 152.32 µM 0.460767801728979 0.321821746690102 no 1098 0.322482602347467 1633 909016 SGTC_3185 9108267 49.47 µM 0.460132213492327 0.322035459142505 no 1099 0.322710661554633 1487 4910486 SGTC_3016 9080866 49.47 µM 0.459895192611334 0.322115170960481 no 1100 0.322795725511235 1497 17066299 SGTC_616 4092-0450 108 µM 0.458505401422239 0.322582732250171 no 1101 0.323294691401914 1580 787165 SGTC_722 3534-0461 190 µM 0.458331026317277 0.322641416327981 no 1102 0.323357318407918 1519 658262 SGTC_23 0213-0011 39.996 µM 0.457061528012067 0.323068785504918 no 1103 0.323813410861836 1615 627608 SGTC_1733 st037357 54.9 µM 0.456823580175346 0.323148915272702 no 1104 0.323898927819563 1447 1272339 YGL099W LSG1 SGTC_1616 st002734 56.1 µM 0.454053011755265 0.324082517173959 no 1105 0.324895335983234 1571 4026101 SGTC_2471 5466956 24.79 µM 0.453044550571406 0.324422614826881 no 1106 0.325258330980437 1576 724419 SGTC_2389 9091542 195.52 µM 0.451926971086024 0.324799683129669 no 1107 0.32566079680903 1531 3626624 YOL127W RPL25 SGTC_1052 3253-3998 198 µM 0.451615516624093 0.324904799040158 no 1108 0.325772994899404 1511 5450317 SGTC_500 h-89 112 µM 0.450728163586958 0.32520435719653 no 1109 0.326092740711101 1683 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_199 4063-0024 41.6 µM 0.449224264863347 0.325712310652425 no 1110 0.32663494251235 1620 306215 SGTC_225 nsc-122657 1.016 µM 0.448791680428526 0.325858479398309 no 1111 0.326790970424169 1581 275685 SGTC_3190 9110366 49.47 µM 0.447283408180848 0.326368328508984 no 1112 0.327335222567558 1654 17123768 SGTC_2450 5739737 12.93 µM 0.447215093678213 0.326391428906488 no 1113 0.327359882200225 1552 2262825 SGTC_1407 3909-7909 12.3 µM 0.446540349731192 0.326619627832899 no 1114 0.3276034864262 1547 4411780 SGTC_1873 rapamycin 2 nM 0.445938528628838 0.326823218947905 no 1115 0.327820825104236 1550 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.444999980889882 0.327140824810111 no 1116 0.328159883967731 1588 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_335 4077-0256 27.6 µM 0.44432489589168 0.327369351955689 no 1117 0.32840385212547 1636 3121989 SGTC_1709 st033179 39.1045 µM 0.443416033212327 0.327677118809147 no 1118 0.328732420500508 1542 573381 SGTC_804 1595-0054 20.9 µM 0.441871694491747 0.328200344476307 no 1119 0.329291027216829 1551 761523 Stimulates phospholipase C. SGTC_136 0097-0015 404.482 µM 0.437944370320053 0.329532448715684 no 1120 0.330713305103165 1601 4861337 SGTC_1892 st058411 7.36 µM 0.437695433102795 0.329616958595663 no 1121 0.330803540254604 1643 3934738 SGTC_1002 4049-0206 172 µM 0.436898520484383 0.329887555142414 no 1122 0.331092472483086 1534 4662749 SGTC_2088 5278280 127.392 µM 0.436749551131764 0.329938148478657 no 1123 0.331146494649127 1599 791502 SGTC_1186 1319-0216 26 µM 0.436158672763804 0.330138854670394 no 1124 0.331360805074148 1712 4565136 SGTC_2271 7849410 118.62 µM 0.435525056482403 0.33035413215792 no 1125 0.331590677830962 1666 972430 SGTC_59 0330-0160 1.33 µM 0.435091609228812 0.330501432564584 no 1126 0.331747966834691 1604 4293482 SGTC_259 usnic acid 108.925 µM 0.434223172397982 0.330796636513836 no 1127 0.332063193756765 1630 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1332 1480-0653 17.5 µM 0.434212570906363 0.330800240883385 no 1128 0.332067042642152 1623 5749438 SGTC_1308 1187-1617 41.4 µM 0.433359981192707 0.331090161653961 no 1129 0.332376634429635 1567 2882570 SGTC_2830 7992007 71.43 µM 0.431835869384413 0.331608683971778 no 1130 0.332930353798614 1567 1952075 SGTC_1826 st055655 41.6 µM 0.430982669819213 0.33189909438925 no 1131 0.333240485775926 1577 676168 SGTC_1975 st070967 30.8 µM 0.42954403990341 0.332389001180211 no 1132 0.333763675736553 1680 261391 SGTC_1911 st060208 74.3 µM 0.429215661931876 0.332500866237472 no 1133 0.333883143100869 1665 688783 SGTC_2248 tofa 1.1 µM 0.428570166170801 0.332720803945296 no 1134 0.334118030331695 1603 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3349 9149703 23.001 µM 0.42749020473849 0.333088904485367 no 1135 0.334511159061869 1536 4910494 SGTC_366 0181-0206 4.31 µM 0.426707604147147 0.333355751321428 no 1136 0.334796155640169 1757 274874 SGTC_2332 7982454 138.89 µM 0.426015903861418 0.333591673712163 no 1137 0.335048128662247 1569 2981748 SGTC_1051 3253-3903 78 µM 0.425977202080378 0.333604875907467 no 1138 0.335062229166451 1545 5509239 SGTC_135 0933-0004 26.348 µM 0.425351051145026 0.333818501083269 no 1139 0.335290391629377 1531 21230617 YGL099W LSG1 SGTC_1463 k081-0032 34.1 µM 0.42042077070013 0.335502452220346 no 1140 0.337089048601988 1510 977755 SGTC_2054 5233173 129 µM 0.42038817044205 0.335513597980994 no 1141 0.337100954235735 1629 6889 SGTC_1860 st056228 74.6 µM 0.418075372087421 0.336304693642848 no 1142 0.337946005356398 1567 688679 SGTC_2949 9072542 2.23 µM 0.417453948640119 0.336517376112111 no 1143 0.338173200776141 1561 16457352 SGTC_39 0986-0283 58.349 µM 0.417227003761337 0.336595061148997 no 1144 0.338256187620351 1743 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1323 1348-1351 11.2 µM 0.415235101522097 0.337277204056811 no 1145 0.33898490250136 1581 6989654 SGTC_62 0180-0423 3.232 µM 0.414668238338498 0.337471428839499 no 1146 0.339192393298461 1612 30102 YGL099W LSG1 SGTC_2368 9071271 200 µM 0.411801475482947 0.338454332490376 no 1147 0.340242469912907 1560 27209959 SGTC_884 0851-0618 334 µM 0.407744562242846 0.33984717483115 no 1148 0.3417306088912 1714 9642473 SGTC_1931 st074438 57.1 µM 0.40673092299439 0.340195525758608 no 1149 0.34210281304031 1572 2787313 SGTC_1700 st030840 7.9285 µM 0.401836273298738 0.341879554275632 no 1150 0.343902262437338 1744 5499307 SGTC_1439 4092-1168 46 µM 0.399808051466336 0.342578299426595 no 1151 0.344648950016461 1648 2886240 SGTC_575 k072-0246 11.9 µM 0.398617566572918 0.342988686036491 no 1152 0.345087507967395 1640 6796779 SGTC_2977 9011197 71.43 µM 0.396976221689553 0.343554797887903 no 1153 0.345692497661537 1676 2704722 SGTC_2841 9004761 38.96 µM 0.395949248518337 0.343909187092906 no 1154 0.346071234333145 1524 2991039 SGTC_1092 toremifene 6.32 µM 0.394586141397643 0.344379781667137 no 1155 0.346574171450252 1636 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2942 9052777 62.25 µM 0.392262356070324 0.345182592962444 no 1156 0.347432187408367 1683 6469503 SGTC_1824 st053723 68.6 µM 0.391795714787233 0.345343890349677 no 1157 0.347604580779827 1581 675225 SGTC_3242 9133940 49.47 µM 0.391685032726391 0.345382152397623 no 1158 0.347645475173544 1679 17248444 SGTC_3175 9106517 49.47 µM 0.391012019824875 0.345614842458188 no 1159 0.347894175612528 1611 41468073 SGTC_2551 apiole 73.87 µM 0.390201127991858 0.345895280801361 no 1160 0.348193913794301 1656 10659 A possible DNA adduct former. SGTC_3138 9097216 49.47 µM 0.389019095735712 0.346304225564987 no 1161 0.348631010246361 1636 25237486 SGTC_2715 st079500 56.4 µM 0.386262454468993 0.347258629682446 no 1162 0.349651151925536 1594 28246688 SGTC_2304 7443016 91.4 µM 0.386140229654225 0.347300968835663 no 1163 0.349696408494086 1618 939854 SGTC_181 1447-1644 8.07 µM 0.384618258238518 0.347828345133499 no 1164 0.350260132376415 1749 534600 SGTC_80 0159-0065 512.242 µM 0.382196466078464 0.348668124044905 no 1165 0.35115782144786 1705 1548079 SGTC_448 monastrol 171 µM 0.381285681907868 0.34898413915182 no 1166 0.351495638427289 1675 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2691 st077356 60.2 µM 0.38110745419655 0.349045991147705 no 1167 0.351561758215093 1750 2839272 SGTC_2203 7227154 166.4 µM 0.380958523864247 0.349097678881664 no 1168 0.351617012562578 1667 896304 SGTC_420 mitomycin C 81.9 mM 0.380218575473669 0.349354526727641 no 1169 0.351891585810478 1629 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1978 st071761 42 µM 0.379386725646206 0.3496433574092 no 1170 0.352200353241818 1611 5147680 SGTC_1937 st074714 47.2 µM 0.378570641671221 0.349926798552209 no 1171 0.35250336338533 1573 17250970 SGTC_3052 9092717 49.47 µM 0.376408716856637 0.350678079197807 no 1172 0.353306533300928 1649 25237534 SGTC_2729 fluphenazine 10.66 µM 0.375331653719454 0.351052582770164 no 1173 0.353706913873345 1593 3372 An atypical antipsychotic. SGTC_2338 7999974 200 µM 0.374647362230837 0.351290591664417 no 1174 0.353961372145965 1845 315925 SGTC_1512 0259-0544 12.2 µM 0.373812000826396 0.351581224458865 no 1175 0.354272095184921 1721 18476 SGTC_227 fluconazole 33.516 µM 0.373074009331901 0.351838053233556 no 1176 0.354546681019873 1621 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2131 toluylene red 5.2905 µM 0.372419845233992 0.352065765737917 no 1177 0.354790140263147 1599 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2155 5570423 76 µM 0.372307831380588 0.352104762737523 no 1178 0.354831834237025 1666 797402 SGTC_266 formosanin C 406 nM 0.371045472881854 0.35254435327238 no 1179 0.355301831427681 1692 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_317 4495-0002 170 µM 0.370225756054675 0.352829908433173 no 1180 0.355607143673954 1651 15991618 SGTC_700 3453-2283 142 µM 0.36917082941934 0.353197522899952 no 1181 0.356000198660305 1747 565664 SGTC_1250 0485-0349 40.2 µM 0.369089082959258 0.353226015138034 no 1182 0.356030662960461 1642 6842794 YDL195W SEC31 SGTC_3050 9093513 49.47 µM 0.368319822268292 0.353494176615669 no 1183 0.356317386900316 1653 25236664 SGTC_1667 st014849 34.6 µM 0.365982214329614 0.354309504089647 no 1184 0.357189173589733 1698 5348460 SGTC_786 4544-0069 423 µM 0.365702484440489 0.354407115101585 no 1185 0.357293546024683 1754 748821 YLR208W SEC13 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.364357735115596 0.354876495256667 no 1186 0.357795445981231 1808 6728940 SGTC_217 ketoconazole 989 nM 0.364148946078545 0.354949392137854 no 1187 0.357873394264147 1681 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_3005 9076496 71.4286 µM 0.363570846584162 0.355151258261451 no 1188 0.358089250029599 1731 21368410 SGTC_63 0099-0242 26.702 µM 0.363165354768354 0.355292875905855 no 1189 0.358240683132579 1755 3898502 YLR359W ADE13 SGTC_3075 9116269 49.47 µM 0.362665940034384 0.355467323508356 no 1190 0.35842722290158 1691 17015205 YNL244C SUI1 SGTC_1838 st055369 84.5 µM 0.362405362697072 0.35555835625982 no 1191 0.358524566319061 1645 676036 SGTC_1814 st052110 31.539 µM 0.361880477611228 0.355741749993823 no 1192 0.358720674620314 1789 674163 SGTC_396 dithiazanine 1.25 µM 0.361102282017721 0.356013711329083 no 1193 0.359011493694069 1650 10578 An antihelmenthic. SGTC_688 0527-0193 473 µM 0.360934293151314 0.356072429168288 no 1194 0.35907428345826 1728 4007154 SGTC_1067 clotrimazole 1.36 µM 0.358559508992993 0.356902861872813 no 1195 0.359962321140849 1689 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_15 0266-0086 27.098 µM 0.35812067887968 0.357056389739549 no 1196 0.360126502226736 1778 1712902 YIL048W NEO1 SGTC_947 3447-0010 211 µM 0.357346884814452 0.357327163537013 no 1197 0.360416067426952 1668 748350 SGTC_1591 genipin 88.4 µM 0.356556773161678 0.357603721493241 no 1198 0.360711821539453 1759 442424 A DNA cross-linking agent. SGTC_2996 9066192 71.4286 µM 0.353295773981942 0.358745938975542 no 1199 0.361933356698689 1588 6472854 SGTC_12 0849-0099 9.267 µM 0.353136223779392 0.358801856531133 no 1200 0.361993158711364 1774 6071388 SGTC_2779 methotrexate 400 µM 0.352685615242439 0.358959797633604 no 1201 0.362162072316906 1724 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_573 3702-0553 84.7 µM 0.351796073664397 0.359271658270827 no 1202 0.362495601671362 1703 1222756 SGTC_2137 5261020 140 µM 0.351173209478021 0.35949008144148 no 1203 0.362729203766919 1693 763655 SGTC_2046 4110841 106 µM 0.350546803614708 0.35970979290129 no 1204 0.362964185689343 1796 44119630 YMR134W ERG29 SGTC_2419 paclitaxel 166.5 µM 0.34731107429083 0.360845459942647 no 1205 0.364178815966516 1742 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2698 st077697 67.5 µM 0.346291633977934 0.361203515080908 no 1206 0.364561777627354 1633 3154499 SGTC_2154 5570129 200 µM 0.345975901697277 0.361314433520397 no 1207 0.364680412658112 1720 673366 SGTC_3275 9138069 49.47 µM 0.345410897961449 0.361512951450293 no 1208 0.36489274269352 1762 17617007 SGTC_1968 st069590 43.6 µM 0.344198145277463 0.361939186258013 no 1209 0.365348638520585 1792 6384066 SGTC_392 N-ethylmaleimide 8.33 µM 0.342599614684443 0.362501268448161 no 1210 0.36594984599145 1686 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_407 eburnamonine 100 µM 0.341875517252458 0.362755976344011 no 1211 0.366222287550697 1668 3195 SGTC_3112 9123419 49.47 µM 0.341651467590947 0.362834800171723 no 1212 0.366306599875248 1742 17015854 SGTC_159 3970-0959 50 µM 0.341532134107558 0.362876785745043 no 1213 0.366351508997498 1765 6615653 SGTC_1597 7-benzyloxygramine 47.5 µM 0.338335319522065 0.364002145798598 no 1214 0.367555255156013 1683 260807 SGTC_395 anisomycin 6.25 µM 0.337824870978915 0.36418194560316 no 1215 0.367747583150151 1718 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_92 0063-0024 660.874 µM 0.337641737873586 0.364246459485677 no 1216 0.367816592556076 1803 3594437 SGTC_2047 4141938 200 µM 0.334225122660605 0.365450763581314 no 1217 0.369104843908063 1739 3807862 SGTC_2581 avocatin a 64 µM 0.333574397013111 0.365680285205188 no 1218 0.369350370448056 1717 6710728 A skin care supplement. SGTC_817 1391-0715 46 µM 0.332867594819166 0.365929640438189 no 1219 0.369617115723034 1680 1353946 SGTC_2763 lisinopril 49.32 µM 0.3321400428013 0.366186375239395 no 1220 0.369891757481278 1812 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1402 3909-7673 35.9 µM 0.331557159818333 0.366392103213009 no 1221 0.370111836389985 1701 5328014 SGTC_1763 st044482 94.5 µM 0.329370183032306 0.367164336420008 no 1222 0.370937951049037 1799 88505 SGTC_1915 st067105 30.6 µM 0.325801502101472 0.368425610131141 no 1223 0.372287271088812 1686 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2132 5317594 122.667 µM 0.325063085194773 0.368686765385728 no 1224 0.372566663402654 1787 794577 SGTC_3141 9094609 49.47 µM 0.324414664632201 0.36891614173526 no 1225 0.372812059415563 1672 25236309 YDL196W YDL196W SGTC_1107 amlodipine 47 µM 0.323486533562359 0.369244545870304 no 1226 0.373163402221243 1712 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3195 9113082 49.47 µM 0.321816774905598 0.369835603094219 no 1227 0.373795752636988 1888 17018038 SGTC_158 k038-0087 26.446 µM 0.321797036811601 0.369842591780528 no 1228 0.373803229640401 1759 X158 SGTC_1146 3579-1023 7 µM 0.321674987937009 0.36988580669995 no 1229 0.373849464128319 1870 X1146 SGTC_445 e6 berbamine 66 µM 0.321119275851948 0.370082593335419 no 1230 0.374060001615695 1737 6610268 A calcium/calmodulin antagonist. SGTC_720 r052-1644 49.9 µM 0.321107248433132 0.370086852815172 no 1231 0.374064558748013 1743 1422863 YOR257W CDC31 SGTC_603 3794-0023 45.9 µM 0.320030821883877 0.370468131007659 no 1232 0.374472482899431 1846 3802260 SGTC_3348 9149464 3.537 µM 0.318743489350126 0.370924280755844 no 1233 0.374960516804191 1746 1951442 SGTC_308 4092-1169 104 µM 0.316670364378771 0.371659247110651 no 1234 0.375746869061059 1758 2268590 YDL196W YDL196W SGTC_167 3672-0051 66.205 µM 0.31384202872442 0.37266270599 no 1235 0.376820510798384 1702 3237971 SGTC_2722 naftopidil 47.16 µM 0.313575551648113 0.372757293480621 no 1236 0.37692171528438 1840 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2094 5332512 191.667 µM 0.313348554938268 0.372837873252133 no 1237 0.377007932317551 1845 755774 SGTC_2323 6148992 148.28 µM 0.313158672135342 0.372905282524887 no 1238 0.377080057597581 1721 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2998 9066762 71.4286 µM 0.312560053258833 0.373117820458033 no 1239 0.377307465672913 1860 4945196 SGTC_229 benomyl 22.8748 µM 0.312366942877035 0.373186391992463 no 1240 0.37738083505409 1750 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2100 5377183 190 µM 0.311982988963092 0.373322742057202 no 1241 0.377526725706673 1855 2844202 SGTC_3125 9127534 49.47 µM 0.311719888010574 0.373416183868517 no 1242 0.377626706051282 1812 1639235 SGTC_2853 9015042 58.44 µM 0.311414526184203 0.373524644204413 no 1243 0.377742756127615 1686 6457456 SGTC_318 1488-0629 67.2 µM 0.310110455621335 0.373987944857318 no 1244 0.37823848075883 1740 3662576 SGTC_834 0312-0008 75.7 µM 0.308676810880421 0.374497489801152 no 1245 0.378783692606101 1750 6385573 YIL048W NEO1 SGTC_1764 st044502 93.5 µM 0.308101646237799 0.374701976065683 no 1246 0.379002494304091 1757 8407 SGTC_2622 2-methoxyxanthone 59.94 µM 0.30518734990546 0.375738626109 no 1247 0.380111733218361 1908 71034 A hepatoprotective. SGTC_1328 1441-0025 69.2 µM 0.304217714357192 0.376083736443299 no 1248 0.38048101496443 1668 4562601 SGTC_1010 4112-3296 15.2 µM 0.303981723874172 0.376167744611843 no 1249 0.380570907474423 1928 704384 SGTC_479 n-linoleoylglycine 10 µM 0.302444631020387 0.37671506413512 no 1250 0.381156568059828 1763 6433346 An anti-infammatory. SGTC_2784 7567673 72.73 µM 0.30229217791726 0.376769362323246 no 1251 0.381214670355074 1752 3471247 SGTC_1280 0880-0253 10.1 µM 0.301995557022354 0.376875014760987 no 1252 0.381327724954238 1778 6836607 SGTC_1780 st038448 24.544 µM 0.300345577401667 0.377462883766135 no 1253 0.381956785635154 1860 728868 YDL195W SEC31 SGTC_435 c-PAF 6.7 µM 0.299542715076162 0.377749037308217 no 1254 0.382262992666434 1911 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_685 1278-0033 54.9 µM 0.298636053851197 0.378072267184929 no 1255 0.382608876533495 1865 3590572 SGTC_1773 st048542 73.5835 µM 0.298350781021346 0.378173986235065 no 1256 0.382717725176794 1708 3237138 SGTC_586 0957-0265 8.15 µM 0.297077439130317 0.378628121585642 no 1257 0.383203694107452 1878 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2382 9035899 200 µM 0.297065797148767 0.378632274454131 no 1258 0.383208138100723 1765 6462679 SGTC_1702 st027038 51 µM 0.29553448395518 0.379178638703701 no 1259 0.383792806842657 1814 5521182 SGTC_2434 5670830 169.91 µM 0.294127972245193 0.379680687224935 no 1260 0.384330058498999 1780 1549830 SGTC_613 3914-0030 117 µM 0.293321714560964 0.379968569107679 no 1261 0.384638128705173 1811 1145395 SGTC_185 k048-0037 25.491 µM 0.290935357954386 0.38082102943888 no 1262 0.385550379328243 1925 6827589 SGTC_2644 guaiazulene 100 µM 0.289822330572154 0.38121882610433 no 1263 0.385976081696527 1892 3515 A coloring agent. SGTC_1795 st049545 62.3 µM 0.288202023783306 0.381798149046419 no 1264 0.386596049863663 1950 5291882 SGTC_2626 ethyl orsellinate 100 µM 0.286477496542333 0.382415025788568 no 1265 0.387256213351325 1770 75653 A natural product. SGTC_944 3370-0224 231 µM 0.285476405955234 0.382773260689351 no 1266 0.387639588991377 1741 4580514 SGTC_2536 dehydroabietamide 32.04 µM 0.28422101516886 0.383222637296251 no 1267 0.388120505751457 1908 3983547 SGTC_456 gingerol 170 µM 0.282206006807499 0.383944253137854 no 1268 0.388892776337535 1837 442793 A herb. SGTC_1180 1193-0155 285 µM 0.281209638513427 0.384301221975545 no 1269 0.389274806185825 1787 2921347 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.279405670268886 0.384947779163205 no 1270 0.389966760026359 1814 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1275 0867-0008 21.1 µM 0.27938476936483 0.384955272099562 no 1271 0.389974779101023 1831 3422836 SGTC_3276 9139060 49.47 µM 0.27881786250278 0.385158523563085 no 1272 0.390192302778799 1844 4870619 SGTC_1262 0737-0114 49.6 µM 0.276781557028829 0.385888854079777 no 1273 0.390973921748456 1956 765919 SGTC_2680 butyl paraben 22.24 µM 0.276692047144831 0.385920966522896 no 1274 0.391008289507664 1870 7184 An antifungal and steroid mimetic. SGTC_1847 st056231 15 µM 0.276590687874935 0.385957330979224 no 1275 0.391047207924387 1775 5393180 SGTC_1728 st035614 33.7865 µM 0.275840581612265 0.386226476185637 no 1276 0.391335256400773 1830 15945546 SGTC_1477 0139-0234 16 µM 0.275503218226138 0.386347543212332 no 1277 0.391464826832901 1862 620880 SGTC_606 k015-0008 38.6 µM 0.274174918960602 0.386824327293535 no 1278 0.391975100812935 1938 1970475 SGTC_1132 3456-3614 2.5 µM 0.273967407861332 0.386898827454601 no 1279 0.392054834230716 1987 3125502 SGTC_2224 6650123 117.647 µM 0.270416821722947 0.388174194318756 no 1280 0.393419800075271 1837 2908370 SGTC_1243 0416-0003 5.65 µM 0.270167477914593 0.388263803868928 no 1281 0.393515705758465 1810 2141977 SGTC_126 0417-1624 672.48 µM 0.268000421486679 0.389042853863686 no 1282 0.39434949714927 1978 41912 YDL195W SEC31 SGTC_2437 5741531 144.16 µM 0.266679430997412 0.389517964966957 no 1283 0.394857996117302 1949 2262990 SGTC_2570 licareol 100 µM 0.266665776002252 0.389522877024136 no 1284 0.394863253375988 1797 443158 SGTC_139 0099-0334 718.624 µM 0.266508887030826 0.389579315336926 no 1285 0.394923657986197 1976 97690 SGTC_477 mead ethanolamide 10 µM 0.266145888096943 0.389709907357051 no 1286 0.39506342770747 1866 16061185 SGTC_917 harmaline 728.087 nM 0.266104751684241 0.389724707324736 no 1287 0.395079267793331 1886 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2482 5981709 142.65 µM 0.265444706324691 0.389962198838731 no 1288 0.395333450139024 1868 877755 SGTC_1013 4112-3890 241 µM 0.264126676971484 0.390436563011595 no 1289 0.395841154166177 1806 705171 SGTC_1257 0669-0121 16 µM 0.263207369171579 0.390767522285645 no 1290 0.396195375615266 1926 4307855 SGTC_3264 9137442 49.47 µM 0.262706712814142 0.390947796487485 no 1291 0.396388321200394 1943 17015726 SGTC_1441 4106-0040 13 µM 0.261422863582293 0.391410186453758 no 1292 0.396883213658644 1876 2904180 SGTC_1686 st019653 115.5 µM 0.261045866689645 0.391545994492645 no 1293 0.397028568321926 1962 97252 SGTC_91 0417-1751 58.384 µM 0.259655552388829 0.392046950596124 no 1294 0.397564740459657 1946 6795624 SGTC_840 0245-0196 390 µM 0.259092061524601 0.392250037859102 no 1295 0.397782104855648 1921 3827528 SGTC_557 1315-0110 16.2 µM 0.258422670702416 0.392491330577352 no 1296 0.398040360984585 1805 6833801 SGTC_2811 7967822 32.47 µM 0.257728929326621 0.392741444461422 no 1297 0.39830805888903 1909 2232244 SGTC_377 3970-0964 33.1 µM 0.256976248025108 0.393012857998305 no 1298 0.398598554412709 1894 16481235 SGTC_1333 1482-0047 286 µM 0.254668910946612 0.393845197125607 no 1299 0.399489415066405 1968 3811116 SGTC_2985 9022375 71.43 µM 0.254269901588574 0.393989183404627 no 1300 0.399643525429862 1873 4939335 SGTC_1676 st018489 23.4 µM 0.254094724965486 0.394052402115363 no 1301 0.399711189267497 1832 3696235 SGTC_1974 st069448 26.9 µM 0.2526236223932 0.394583411774775 no 1302 0.400279536976275 1972 6323587 YNR016C ACC1 SGTC_2245 6637752 200 µM 0.250846504355258 0.395225142110799 no 1303 0.400966392743133 1985 681890 SGTC_3135 9127742 49.47 µM 0.250553750178284 0.39533088510534 no 1304 0.401079571609671 1825 3643468 SGTC_3301 9125354 19.7965 µM 0.249589304854007 0.395679297848615 no 1305 0.40145248518401 1820 41905162 SGTC_1367 1812-0510 76.9 µM 0.247273018689739 0.396516412829829 no 1306 0.402348469247681 1902 1142582 YDR527W RBA50 SGTC_2289 7946404 165.07 µM 0.246515554133522 0.396790267256076 no 1307 0.402641582715382 1837 1246120 YPR165W RHO1 SGTC_1614 st002383 48.6 µM 0.245036001395671 0.397325332831421 no 1308 0.403214277911685 1971 1947235 SGTC_2703 st077852 53.4 µM 0.244472120099957 0.397529305832511 no 1309 0.403432595960691 1887 6281836 SGTC_997 3996-0078 137 µM 0.242686246416445 0.398175495274959 no 1310 0.404124231379639 1883 735687 SGTC_1270 0831-1170 17.3 µM 0.242415440485615 0.398273506447581 no 1311 0.404229135673769 1898 6764716 SGTC_3263 9137018 49.47 µM 0.240935962790743 0.398809078130636 no 1312 0.404802374370767 1780 43844957 SGTC_3158 9100007 49.47 µM 0.240184768392155 0.399081083905616 no 1313 0.405093510591797 1820 19297233 SGTC_565 1418-0001 44.5 µM 0.240106388673728 0.399109467848443 no 1314 0.40512389081115 1964 2862145 SGTC_992 3909-8734 162 µM 0.237345227722261 0.400109716825106 no 1315 0.40619448882881 1846 4288319 SGTC_1818 st052136 56.3 µM 0.237192630650691 0.400165015311141 no 1316 0.406253676550822 1892 674169 SGTC_626 0214-0009 33 µM 0.237099270152474 0.400198848495315 no 1317 0.406289889279937 1957 3437874 SGTC_901 1112-0062 60.1 µM 0.235123631933483 0.400914981063256 no 1318 0.40705638857495 1884 1908457 SGTC_208 k072-0098 12.366 µM 0.235055348096312 0.400939738669023 no 1319 0.40708288741675 1979 5948901 SGTC_885 0865-0106 16.8 µM 0.231485882080571 0.402234468260686 no 1320 0.408468676044705 1828 2793380 SGTC_2112 5488546 200 µM 0.230899276886608 0.402447346884134 no 1321 0.408696526259332 1902 600757 SGTC_2737 bleomycin 30.5 nM 0.228391158539821 0.403357866886487 no 1322 0.409671081149497 1938 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1384 3089-0840 101 µM 0.228350875816139 0.403372494978103 no 1323 0.40968673798336 2003 1069836 SGTC_2225 6654152 15.4 µM 0.226088467472501 0.40419427246655 no 1324 0.410566307004322 1977 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1648 st011736 69.8 µM 0.225821113067924 0.404291411963266 no 1325 0.41067027767187 1986 2855514 SGTC_1962 st076595 64.5 µM 0.223939800884692 0.404975127056296 no 1326 0.411402072729596 1896 279619 SGTC_2199 6590217 200 µM 0.222361398045979 0.405548981396201 no 1327 0.412016279742763 1991 703109 SGTC_440 fluspirilene 35.1 µM 0.221821696465332 0.405745245442632 no 1328 0.412226344423321 1977 3396 An atypical antipsychotic. SGTC_2627 acetyl isogambogic acid 100 µM 0.221390331618169 0.405902129562082 no 1329 0.412394259959451 1843 6857789 A caspase activator and apoptosis inducer. SGTC_1473 k844-0725 134 µM 0.221055753795879 0.406023823383909 no 1330 0.412524510671856 1998 54682906 SGTC_2880 9042983 58.44 µM 0.22075988208484 0.406131446448978 no 1331 0.412639701172254 1909 6464714 SGTC_669 0108-0021 26.2 µM 0.219896872131516 0.406445406024386 no 1332 0.412975736186905 2134 17201 SGTC_333 3486-0131 40.1 µM 0.219123675245116 0.406726743061832 no 1333 0.413276854358205 2029 6744690 SGTC_1502 4534-4282 27.7 µM 0.218186173495444 0.407067928978878 no 1334 0.413642028765662 1914 3278949 SGTC_878 0828-0289 13.7 µM 0.217836302006882 0.407195276134462 no 1335 0.41377832939058 1879 745350 YLR208W SEC13 SGTC_1560 lithocholic acid 53.1 µM 0.217746585734381 0.40722793288305 no 1336 0.413813282137904 2028 9903 A bile acid which acts as a detergent. SGTC_846 0335-0850 148 µM 0.216903430438195 0.407534873129041 no 1337 0.414141802072087 1993 6819598 SGTC_1736 st036774 51 µM 0.216692268979671 0.40761175274079 no 1338 0.414224086662908 2078 1272247 SGTC_1437 4092-1038 11.6 µM 0.216332155769527 0.407742870876446 no 1339 0.414364422887448 1931 3977136 SGTC_968 1309-0633 340 µM 0.213959245018951 0.40860711146574 no 1340 0.415289419478536 2045 3761976 SGTC_3090 9117696 49.47 µM 0.213285169778415 0.408852698471583 no 1341 0.415552270118639 2027 7923821 SGTC_2043 5101342 149 µM 0.21281498734285 0.409024022051376 no 1342 0.415735636653093 1945 678451 SGTC_128 0906-2981 13.371 µM 0.211919782167152 0.409350262090472 no 1343 0.416084808577313 2040 6740226 SGTC_1198 1612-1005 86.7 µM 0.211151517566967 0.409630291191985 no 1344 0.41638452056816 2012 6998509 SGTC_937 3122-0005 46.7 µM 0.210977854353644 0.409693597071353 no 1345 0.416452276037364 2049 759535 SGTC_2311 7694451 200 µM 0.207965164761372 0.41079219355868 no 1346 0.417628083578495 1970 2163142 SGTC_957 1187-1561 14.1 µM 0.207501302495541 0.410961406311033 no 1347 0.417809187782314 2044 1538454 SGTC_304 1310-0298 97 µM 0.206992230135379 0.411147130366227 no 1348 0.418007963275569 1946 1550234 SGTC_1870 st057514 26.5 µM 0.206422051362222 0.411355171421196 no 1349 0.41823062361786 1924 5393161 SGTC_3328 9140624 29.0385 µM 0.205621963875074 0.411647141259625 no 1350 0.418543109717822 2037 4904392 SGTC_1227 3909-8010 46.6 µM 0.205350508172373 0.411746212648171 no 1351 0.418649142481291 1951 15982272 SGTC_1770 st043884 66.3 µM 0.202025873712525 0.412960037023524 no 1352 0.419948248457094 2032 670149 SGTC_693 4161-2696 114 µM 0.201283773552772 0.413231091945937 no 1353 0.420238344871467 2027 805759 SGTC_983 1491-0821 12.2 µM 0.200831547659513 0.413396289475527 no 1354 0.420415146999411 2047 46495113 SGTC_2651 TUB2.036 5 µM 0.199284659019091 0.413961481631244 no 1355 0.42102003941243 2055 15992207 YFL037W TUB2 SGTC_166 k072-0058 166.424 µM 0.1991913732498 0.413995571492368 no 1356 0.421056523680021 2099 5846229 SGTC_785 1270-0111 65.3 µM 0.194334336562252 0.415771390879846 no 1357 0.422957050703032 2098 6741994 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.192602020245908 0.416405175032217 no 1358 0.423635331313146 1906 2374 Ca(2+)-ATPase inhibitor. SGTC_3104 9120930 49.47 µM 0.191464479703786 0.416821473252258 no 1359 0.424080853399367 1987 17014836 SGTC_1105 epirubicin 18.1 µM 0.18974356269851 0.417451443099449 no 1360 0.424755041377794 1915 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1989 st071868 50.2 µM 0.189449735135096 0.417559024717264 no 1361 0.424870173584889 2079 16414057 SGTC_740 k014-0057 261 µM 0.187724338545954 0.418190883296218 no 1362 0.425546375026177 2065 4012779 SGTC_1835 st008666 49.2 µM 0.187674349141816 0.418209193103503 no 1363 0.425565969684814 1923 690455 SGTC_864 0469-0573 172 µM 0.186699024684002 0.41856646428348 no 1364 0.425948310422139 1899 689425 SGTC_2987 9018338 71.43 µM 0.185552850053136 0.418986405454682 no 1365 0.426397715765781 2096 5055682 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.185394532917679 0.419044417742784 no 1366 0.426459798097087 1945 5282362 SGTC_2129 girgensonine 121.053 µM 0.183292261594566 0.419814921281672 no 1367 0.427284352948367 2002 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2150 5556613 200 µM 0.182845968005402 0.419978532027198 no 1368 0.427459439654616 1989 743190 SGTC_1901 st060216 58.6 µM 0.182595139822761 0.420070491439551 no 1369 0.427557849045692 1996 688792 SGTC_2470 5664817 21.68 µM 0.180884964376089 0.420697597362816 no 1370 0.428228935431327 2116 2859561 SGTC_999 SEC7.066 22.7 µM 0.179082243366047 0.421358856829479 no 1371 0.428936562178659 2006 740511 YDR170C SEC7 SGTC_320 4092-0846 5.34 µM 0.178014833705005 0.421750500062681 no 1372 0.429355663096683 2062 1359356 SGTC_3294 9122953 26.2835 µM 0.177800983315195 0.42182897322026 no 1373 0.429439637540349 2055 16459826 SGTC_57 miconazole 162.5 nM 0.175521163641151 0.42266575345548 no 1374 0.430335071362242 1993 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_248 streptozotocin 5.23457 mM 0.1752384314334 0.422769551299744 no 1375 0.430446143803697 2112 5300 DNA alkylating agent. SGTC_896 0964-0007 44.5 µM 0.17508350714921 0.422826430033002 no 1376 0.430507008742519 2119 6756758 SGTC_522 1273-0010 11.6 µM 0.175055367181491 0.422836761482847 no 1377 0.430518064238933 2018 5705015 SGTC_1883 5-benzylidenerhodanine 20 µM 0.173280213458789 0.423488607370697 no 1378 0.431215587897621 2104 1273210 SGTC_1050 3232-1156 69.3 µM 0.173262059534308 0.423495274673298 no 1379 0.431222722359196 1949 700529 SGTC_2713 st079149 53.4 µM 0.171880221971101 0.424002839517019 no 1380 0.431765847877455 2009 3103253 SGTC_303 1348-1668 34.2 µM 0.170916811107594 0.424356786068963 no 1381 0.432144588907643 2028 5380509 SGTC_1719 st032227 49.2 µM 0.170473055588417 0.424519837505591 no 1382 0.432319061358946 1955 3125804 SGTC_19 0279-0214 38.434 µM 0.169987211264726 0.424698368666635 no 1383 0.432510097104311 2070 3566274 YBR002C RER2 SGTC_1865 st057639 52.2 µM 0.169122683311698 0.425016091280624 no 1384 0.432850071611316 2114 688818 SGTC_2128 5255449 168.493 µM 0.166593038372336 0.425946039999581 no 1385 0.43384513586203 2038 736008 SGTC_2794 7785382 27.27 µM 0.166255037014279 0.42607032746045 no 1386 0.433978124393559 2155 2205081 SGTC_3221 9128209 49.47 µM 0.165966328704219 0.42617649504751 no 1387 0.434091724217288 2011 16460723 SGTC_140 0062-0056 502.533 µM 0.165351334186296 0.426402666685356 no 1388 0.434333728005807 2048 3758964 SGTC_2409 alverine citrate 63.97 µM 0.16510983714559 0.426491486752406 no 1389 0.434428765178866 2069 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1846 st056244 14.8 µM 0.164425871143161 0.426743062458765 no 1390 0.434697949253336 2047 5393182 SGTC_2192 5915882 198.485 µM 0.163591687991 0.427049931222872 no 1391 0.435026294285836 2088 2876149 SGTC_2643 anethole 100 µM 0.162646170204118 0.427397809742114 no 1392 0.435398516206783 2031 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3272 9137413 49.47 µM 0.1624471233644 0.42747105101932 no 1393 0.435476882267256 2148 17614870 SGTC_1134 3477-0009 42.5 µM 0.16210921522993 0.427595393422476 no 1394 0.435609924740785 2156 3973534 SGTC_961 1252-1571 372 µM 0.161853057447506 0.427689658373951 no 1395 0.435710785012647 2118 6813498 SGTC_3322 9139058 2.11 µM 0.161419487741671 0.427849219545967 no 1396 0.435881509470268 2071 4908926 YPR165W RHO1 SGTC_2472 5377652 49.4 µM 0.160270572691268 0.428272097207856 no 1397 0.436333969394034 1969 1610903 SGTC_3310 9130229 44.1445 µM 0.159911436151083 0.428404300423107 no 1398 0.436475419853736 2097 7761258 SGTC_1652 st011932 78 µM 0.159355373067694 0.428609010917591 no 1399 0.436694448338649 2102 1551076 SGTC_1462 k081-0014 26.5 µM 0.15807087990857 0.429081960881578 no 1400 0.437200473281551 2089 3270634 SGTC_832 4083-0019 164 µM 0.157820674206829 0.429174098410751 no 1401 0.437299053578793 2105 1990758 SGTC_1212 0520-0165 585 µM 0.157374177700629 0.4293385290481 no 1402 0.437474981532939 2150 5403258 SGTC_2477 5967686 25.23 µM 0.15635528138994 0.429713802422675 no 1403 0.437876491928562 2018 776118 SGTC_1880 MG-132 525 µM 0.155284157876398 0.430108380265553 no 1404 0.438298652151367 2137 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1721 st082152 9.2685 µM 0.155279174668959 0.430110216130686 no 1405 0.438300616339541 2106 5296051 SGTC_2663 amphotericin b 100 µM 0.155091025581883 0.430179533304458 no 1406 0.438374778564475 2041 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2421 5690543 90.72 µM 0.155066535171525 0.430188556126971 no 1407 0.438384432043583 2023 3397993 SGTC_554 4483-2211 187 µM 0.153837012649234 0.430641586862914 no 1408 0.438869124660188 2026 747107 SGTC_1233 0325-0408 14.2 µM 0.153527616110664 0.430755601730325 no 1409 0.438991106976571 2095 12874 SGTC_2964 9083345 53.42 µM 0.151993213922327 0.431321125170652 no 1410 0.439596143986199 2011 17741579 SGTC_607 4491-0986 66.8 µM 0.151754418616009 0.431409148909809 no 1411 0.43969031716006 2126 698981 YDR232W HEM1 SGTC_2788 5282734 71.43 µM 0.150161023889487 0.431996586482529 no 1412 0.440318787800966 2119 743706 SGTC_581 0958-0271 211 µM 0.150001034548694 0.432055578156686 no 1413 0.440381899521712 2040 4591145 SGTC_1137 ixabepilone 100 µM 0.149997817539288 0.432056764356068 no 1414 0.44038316856554 2038 154225 A novel microtubule stabilizer. SGTC_2001 4023502 57.655 µM 0.149377179752839 0.432285621933253 no 1415 0.440628008805145 2061 108941 YCR052W RSC6 SGTC_694 1315-0438 43.2 µM 0.149165488103965 0.432363687540403 no 1416 0.440711525890741 2078 6793154 SGTC_2741 miltefosine 3.04 µM 0.149122320628037 0.432379606750587 no 1417 0.440728556748387 2072 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1579 chlormadinone acetate 49.4 µM 0.149010478927202 0.432420852006304 no 1418 0.44077268214734 2141 45114258 A steroidal progestin. SGTC_2301 7769476 200 µM 0.146504143017107 0.433345337029546 no 1419 0.441761709776909 2074 977820 SGTC_899 1083-0020 478 µM 0.145593828132854 0.433681205625072 no 1420 0.442121020251412 2129 767123 SGTC_2302 7771753 200 µM 0.145522333996218 0.433707586040312 no 1421 0.442149241729725 2001 2203047 SGTC_759 3486-0358 89.3 µM 0.144643134544933 0.434032023419521 no 1422 0.442496319443666 2184 875103 SGTC_538 2922-0838 53.3 µM 0.144218603854322 0.434188697340909 no 1423 0.442663925382644 2160 777039 SGTC_1503 4585-0012 61.3 µM 0.143848018407528 0.434325471111599 no 1424 0.442810241973943 2110 2922052 SGTC_406 estrone 100 µM 0.142083345571701 0.434976875061564 no 1425 0.443507086508614 2176 5870 A steroid. SGTC_1266 0828-0227 32.9 µM 0.141961368890472 0.435021907566206 no 1426 0.44355525986905 2081 3913820 SGTC_2184 6075246 200 µM 0.141698247664979 0.435119052017768 no 1427 0.443659179568073 2081 2267320 SGTC_2539 epi(13)torulosol 80 µM 0.140851807278824 0.43543158464857 no 1428 0.443993507350426 2033 6708597 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.140119669146409 0.435701945803309 no 1429 0.444282720085611 2063 6708514 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.139907806475455 0.43578018724811 no 1430 0.444366416641454 2031 688803 SGTC_2902 5787006 60.46 µM 0.139537087597576 0.43591710075586 no 1431 0.444512875463958 2050 591003 SGTC_1930 st074634 34.3 µM 0.13921829007572 0.436034844865402 no 1432 0.444638827927981 2125 684253 YOR116C RPO31 SGTC_847 0342-0274 5.54 µM 0.13834355760481 0.43635794608829 no 1433 0.444984451228518 2141 18097 SGTC_2306 7482397 179.52 µM 0.135970197186379 0.437234811059729 no 1434 0.445922420660466 2154 891448 SGTC_1789 tunicamycin 25 nM 0.134441820294998 0.437799650789946 no 1435 0.446526606985076 2164 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.132856065112355 0.438385829703007 no 1436 0.447153606879793 2141 368090 SGTC_2090 5301565 104.445 µM 0.132239850420919 0.438613651762933 no 1437 0.447397290902842 2074 2056344 SGTC_1485 3909-9022 254 µM 0.130406900291013 0.439291435655736 no 1438 0.448122253784201 2156 714516 SGTC_1602 st001878 87.6 µM 0.126572444750019 0.440709904858426 no 1439 0.449639403700982 2138 595405 YLR310C CDC25 SGTC_3304 9125678 46.087 µM 0.12605262941693 0.440902257647253 no 1440 0.449845132264486 2091 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1546 5-methoxyflavanone 78.7 µM 0.125028919985934 0.441281112448783 no 1441 0.450250327570242 2188 147795 SGTC_2636 apigenin dimethyl ether 100 µM 0.124143449374593 0.441608851127191 no 1442 0.450600848298496 2102 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3225 9130819 49.47 µM 0.124059359617591 0.441639977298171 no 1443 0.450634137918983 2162 4547121 SGTC_634 1611-4317 11.2 µM 0.122026891614579 0.442392412911249 no 1444 0.451438860493846 2213 2843522 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.121133281218335 0.442723300443456 no 1445 0.4517927343309 2173 140250 A respiratory chain inhibitor. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.119313292612346 0.443397332141367 no 1446 0.45251357637259 2106 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3055 9094636 49.47 µM 0.118150396125016 0.44382809605986 no 1447 0.452974246362441 2157 25236176 SGTC_2907 7721985 69.9 µM 0.116143137318566 0.44457178731113 no 1448 0.453769550743885 2076 3267881 SGTC_2393 9031399 185.94 µM 0.115151446874574 0.44493928173696 no 1449 0.454162541183322 2170 1526623 YDL150W RPC53 SGTC_1866 st057638 64 µM 0.11510106243056 0.444957954154295 no 1450 0.454182508902258 2104 688802 SGTC_2909 7941780 10.49 µM 0.114588650659009 0.445147860300755 no 1451 0.454385587955603 2200 1243215 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.114170828672534 0.445302719621309 no 1452 0.454551188009818 2140 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.114044871390912 0.445349405397226 no 1453 0.454601111616972 2197 6710655 SGTC_1016 4226-1401 38 µM 0.114018122019559 0.445359320087612 no 1454 0.454611713915797 2211 2901613 SGTC_1427 4048-4900 550 nM 0.113830926845392 0.445428705186208 no 1455 0.454685910925689 2215 24132586 SGTC_2860 9025725 38.96 µM 0.113825796221015 0.445430606908768 no 1456 0.454687944531302 2035 40546248 SGTC_2662 daunorubicin 22.37 µM 0.1132101511662 0.445658811646931 no 1457 0.454931973971307 2176 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_745 0469-0705 296 µM 0.112795140289436 0.445812656309991 no 1458 0.455096485621526 2207 3486736 SGTC_2928 9011484 9.79 µM 0.109684000434119 0.44696621510104 no 1459 0.456329994826551 2112 2994751 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.108818172294516 0.447287329997324 no 1460 0.456673355002457 2141 2724278 An inhibitor of dopamine biosynthesis. SGTC_186 3455-3465 67.277 µM 0.108517792139835 0.447398741879007 no 1461 0.456792483884882 2201 755278 SGTC_2616 abietic acid 100 µM 0.108512746067722 0.447400613517449 no 1462 0.456794485158579 2246 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_580 1123-0028 41 µM 0.104373972168593 0.448936116677995 no 1463 0.458436288524626 2212 1677248 YPR107C YTH1 SGTC_297 0986-0032 24 µM 0.104028321348198 0.449064389575861 no 1464 0.458573436656775 2157 2847425 SGTC_2495 cafestol 54.53 µM 0.10317067120425 0.44938269117075 no 1465 0.45891375832976 2159 16667697 An anti-infammatory. SGTC_2618 avocadyne 43.43 µM 0.102643938602126 0.449578194765961 no 1466 0.459122784512854 2151 3015189 SGTC_1431 4049-0260 9.09 µM 0.102177269576244 0.449751415218108 no 1467 0.459307984781778 2189 3854841 SGTC_1776 st049249 45.9 µM 0.102127027777706 0.449770064781884 no 1468 0.459327924053819 2085 1822314 SGTC_1434 4073-0095 163 µM 0.10183281539218 0.449879277521697 no 1469 0.459444689059581 2219 24133745 SGTC_291 SEC14.278 35.5 µM 0.101793893264035 0.449893725845994 no 1470 0.459460136470682 2208 1068044 SGTC_2018 5133068 143 µM 0.101307550474732 0.450074267260465 no 1471 0.459653161310731 2191 785362 SGTC_311 1315-0136 58 µM 0.101105458534025 0.450149291388874 no 1472 0.4597333724848 2199 6759207 SGTC_2493 resveratrol 26.09 µM 0.0991667539602041 0.450869101573252 no 1473 0.460502935603436 2211 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_682 0kpi-0099 17 µM 0.0987374291585388 0.451028524985945 no 1474 0.460673374941832 2113 1714895 YML126C ERG13 SGTC_2033 5192550 145 µM 0.0984005454961056 0.451153627282333 no 1475 0.460807120770117 2150 182073 SGTC_3022 9087993 49.47 µM 0.0974964903806107 0.451489373568364 no 1476 0.461166060612322 2239 17173644 SGTC_354 2783-3500 4.88 µM 0.0964490157932359 0.451878426091448 no 1477 0.461581982284844 2099 6740761 SGTC_1632 st005650 90 µM 0.0961686786995048 0.45198255661955 no 1478 0.461693303132561 2154 2759605 SGTC_1891 st059073 26.2 µM 0.094820391582603 0.452483420597305 no 1479 0.462228744853122 2261 688754 SGTC_517 1365-0151 113 µM 0.0947500879499171 0.4525095391909 no 1480 0.462256666236296 2142 768657 SGTC_68 0986-0284 82.829 µM 0.0945648074937632 0.452578373957178 no 1481 0.462330252038738 1949 423278 YIL048W NEO1 SGTC_1178 0988-0033 191 µM 0.0900243606542412 0.454265665756967 no 1482 0.464133928210793 2186 5392207 SGTC_956 1185-0240 191 µM 0.0896897626863855 0.454390039948762 no 1483 0.464266875673319 2186 1416193 SGTC_3326 9140064 16.379 µM 0.0891473645728671 0.454591665513212 no 1484 0.464482397863187 2229 1868434 SGTC_294 k038-0071 157 µM 0.0887885840847872 0.45472504135958 no 1485 0.464624965218786 2161 24152826 SGTC_2944 9067346 25.62 µM 0.0869247930019096 0.455417983336129 no 1486 0.465365646070647 2195 6473075 SGTC_26 0302-0163 425.158 µM 0.0869074110665401 0.455424446436431 no 1487 0.465372554316382 2189 3100915 SGTC_1825 st052143 62.6 µM 0.086376467260783 0.455621872192344 no 1488 0.465583576704099 2243 674173 SGTC_686 1319-0111 510 µM 0.0857697096664241 0.455847501907258 no 1489 0.465824742952792 2230 4562600 SGTC_1022 4477-0945 21.3 µM 0.0855414521343605 0.455932385757628 no 1490 0.465915471091059 2220 4648966 SGTC_1980 st071811 45.7 µM 0.0850198265696017 0.456126374135784 no 1491 0.466122814227209 2224 4974850 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0847103489974346 0.456241471317362 no 1492 0.46624583411677 2221 641818 YHR062C RPP1 SGTC_2508 celastrol 40.54 µM 0.0838426287930318 0.456564202943559 no 1493 0.466590777221599 2249 122724 Celastrol is a natural product and antioxidant. SGTC_3232 9132874 49.47 µM 0.0838142066284616 0.456574774499801 no 1494 0.466602076254616 2160 3784940 SGTC_3036 9090181 49.47 µM 0.0837175088856878 0.456610741224438 no 1495 0.466640517968404 2242 25236586 SGTC_83 0170-0301 39.027 µM 0.0833746339367934 0.456738276421791 no 1496 0.46677682872977 2260 3089716 SGTC_2371 9071574 200 µM 0.0813677825603872 0.457484830481826 no 1497 0.467574734960816 2260 45596039 SGTC_1504 k297-0033 30 µM 0.0807326224976361 0.457721143102086 no 1498 0.467827296241964 2226 4388117 SGTC_1079 idarubicin 2.36 µM 0.0800816633387169 0.457963349317975 no 1499 0.468086153219597 2277 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_830 4076-0286 57.8 µM 0.0794980181736093 0.458180522894632 no 1500 0.468318253947056 2205 6866659 SGTC_1497 4476-2978 41.3 µM 0.0780913933951525 0.458703977252306 no 1501 0.468877676682003 2216 1528379 SGTC_823 0417-1665 178 µM 0.0779244876913151 0.458766093482516 no 1502 0.468944060136854 2177 3429856 SGTC_143 4032-1194 15.74 µM 0.0765242102548573 0.459287265306747 no 1503 0.469501026723698 2250 1806963 SGTC_1461 k072-0203 53.8 µM 0.0756919068072543 0.459597075066448 no 1504 0.469832107477501 2263 5418714 SGTC_2537 larixol 68.93 µM 0.075335461776157 0.459729762735009 no 1505 0.469973903610196 2249 6708759 SGTC_493 zm226600 134 µM 0.0744524258624362 0.460058494634108 no 1506 0.470325197355697 2241 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1164 k060-0068 93.7 µM 0.0733056013866678 0.460485469056541 no 1507 0.470781467216472 2278 5963676 SGTC_1118 chelidonine 707.474 nM 0.0728773428412793 0.460644925781965 no 1508 0.470951861892298 2283 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1299 1079-1439 3.74 µM 0.0721798619318374 0.46090463763061 no 1509 0.471229385607825 2232 323161 SGTC_293 4049-0273 38.5 µM 0.0702453264856194 0.461625062237751 no 1510 0.471999199041862 2235 1380311 SGTC_1152 3909-8331 15.9 µM 0.0702032461050043 0.461640734458009 no 1511 0.47201594534214 2220 16001939 SGTC_1254 0550-0035 264 µM 0.0689071593223282 0.462123472014416 no 1512 0.472531759876141 2250 15121435 SGTC_2877 9040724 71.43 µM 0.0683083825748561 0.462346509937002 no 1513 0.472770075693738 2292 6463895 SGTC_2229 7354935 190 µM 0.0678474898571031 0.462518195603803 no 1514 0.47295351969576 2284 318112 SGTC_2243 6634756 200 µM 0.0673874959140484 0.462689553433645 no 1515 0.473136611688201 2280 885676 SGTC_2395 5646831 180.19 µM 0.0668962916728905 0.462872545428014 no 1516 0.473332132621797 2254 6808628 SGTC_918 glabranin 770.725 nM 0.0660078141959798 0.463203556528751 no 1517 0.473685802098053 2232 124049 Also referred to as licorice root. SGTC_663 1486-0733 13.9 µM 0.0659634051923478 0.463220102214212 no 1518 0.473703480199191 2228 722445 YPR165W RHO1 SGTC_1704 st028805 70.8 µM 0.0654352968429535 0.463416867062845 no 1519 0.473913710735956 2179 2876101 SGTC_3067 9117431 49.47 µM 0.0639588902075018 0.463967000241742 no 1520 0.474501480306869 2222 17150885 SGTC_617 3770-0098 35 µM 0.0624343568165298 0.464535138531056 no 1521 0.475108467767445 2222 5962639 SGTC_1301 naphtanilide LB 4.81 µM 0.0623865186089407 0.464552967271823 no 1522 0.475127515319219 2292 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2917 7979103 53.79 µM 0.0619027542445285 0.464733264588285 no 1523 0.475320137068372 2260 2980565 SGTC_2754 granisetron 64.02 µM 0.0614399479689867 0.464905757674942 no 1524 0.475504419278867 2287 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_803 4488-1585 147 µM 0.0608966313545265 0.465108266280834 no 1525 0.475720766129217 2287 747204 SGTC_2352 9027995 87.8 µM 0.0607733892804415 0.465154203151078 no 1526 0.475769841707323 2240 2997347 SGTC_465 cgp-37157 41 µM 0.0603423371992484 0.465314875821697 no 1527 0.475941491575602 2286 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2134 5324836 1.464 µM 0.0596594180703601 0.46556944233594 no 1528 0.476213446910154 2258 699272 SGTC_251 melphalan 456.522 µM 0.0589315564807449 0.465840777214737 no 1529 0.476503311642321 2238 460612 A DNA alkylator. SGTC_2180 6301957 200 µM 0.0580582529514808 0.46616635141222 no 1530 0.476851113794158 2301 845462 SGTC_2984 9022109 38.96 µM 0.0580022147684228 0.466187243648481 no 1531 0.47687343218436 2305 6459207 SGTC_1287 0971-0001 34.6 µM 0.0568082752209544 0.466632391962348 no 1532 0.477348960956282 2281 4665869 SGTC_78 0336-0123 156.75 µM 0.0561068738890732 0.466893921872155 no 1533 0.477628333997514 2131 6765896 SGTC_3287 9117173 37.0625 µM 0.0558375415341448 0.466994351015435 no 1534 0.477735613881431 2321 2789709 SGTC_1594 piperine 70.1 µM 0.0555704604840304 0.467093942763059 no 1535 0.477841998623688 2312 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2358 9037157 4 µM 0.0552145582939025 0.467226658191212 no 1536 0.477983765393726 2250 2388925 SGTC_455 paf C-16 10 µM 0.0545142603277606 0.467487808945767 no 1537 0.47826272369284 2294 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_173 1273-0061 2.693 µM 0.0528426786857981 0.468111221117924 no 1538 0.478928628154881 2244 2847414 YPL266W DIM1 SGTC_754 3474-0146 171 µM 0.0510369760532182 0.468784741208204 no 1539 0.479648028149383 2294 24762078 SGTC_2373 9071805 200 µM 0.0501551841543172 0.469113678760508 no 1540 0.479999362219908 2331 10149009 SGTC_1886 st057356 49.9 µM 0.0482110115122373 0.469838993648179 no 1541 0.480774037237957 2292 24207747 SGTC_1893 st059353 36.1 µM 0.0468658472894333 0.47034089445379 no 1542 0.481310074042421 2175 3112488 SGTC_3316 9136639 10.545 µM 0.0464353185756239 0.470501541121207 no 1543 0.481481643355188 2250 4903665 SGTC_1985 st071382 65.5 µM 0.0452635413524718 0.470938800090471 no 1544 0.481948623711879 2333 6123237 SGTC_1344 1488-0097 29.1 µM 0.0448375213475352 0.471097781912246 no 1545 0.482118408721798 2286 747966 SGTC_1383 3049-0032 20.7 µM 0.0441056530095387 0.471370910721992 no 1546 0.482410093360777 2316 712864 SGTC_3291 9121177 71.43 µM 0.0436031152678099 0.471558462554341 no 1547 0.482610384218321 2286 17015612 SGTC_1113 artemisinin 1.17947 µM 0.0435677709275668 0.47157165363389 no 1548 0.482624471183221 2340 2240 An anti-malaria and mitochondrial poison. SGTC_215 1287-0124 461.5 µM 0.0425760507611551 0.471941792304175 no 1549 0.483019743449162 2322 5560863 SGTC_735 3076-0345 636 µM 0.0411874897445716 0.472460084115239 no 1550 0.483573213474149 2323 2888990 SGTC_1196 1588-0294 184 µM 0.0401493801527379 0.472847597565337 no 1551 0.483987016922693 2257 6144269 SGTC_502 l-744,832 89.3 µM 0.0397070930134674 0.473012705703722 no 1552 0.484163323365647 2346 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1062 mesoridazine 14.2 µM 0.0395727078801451 0.473062873307556 no 1553 0.484216893172908 2336 4078 A neuroleptic. SGTC_511 blebbistatin 171 µM 0.0391951046618562 0.473203839463474 no 1554 0.484367418276578 2337 3476986 A myosin inhibitor. SGTC_1527 coumarin 137 µM 0.0380207587949216 0.47364226552357 no 1555 0.484835565434169 2297 323 A hepatotoxic, DNA x-linker. SGTC_979 1426-2828 121 µM 0.0371588916864896 0.473964052233423 no 1556 0.485179157820258 2297 747872 SGTC_319 1348-1596 45.5 µM 0.035600864929459 0.474545800084615 no 1557 0.485800309323192 2332 5380505 SGTC_2883 9059145 45.46 µM 0.0354609088488051 0.47459806062312 no 1558 0.485856108488341 2335 16476510 SGTC_2290 7904846 200 µM 0.0352098227428437 0.474691818952759 no 1559 0.48595621483646 2312 2962154 SGTC_473 2-arachidonoylglycerol 10 µM 0.0348498190649397 0.474826250752885 no 1560 0.486099747433291 2302 5282280 An endocannabinoid. SGTC_2927 9011802 47.9 µM 0.0332451451594977 0.475425499282052 no 1561 0.486739548685596 2303 43912568 SGTC_2445 5742597 35.57 µM 0.0310180690779186 0.476257269161991 no 1562 0.487627564782697 2311 1774255 SGTC_272 doxorubicin 8.13 µM 0.0304842512910918 0.476456655298279 no 1563 0.4878404265969 2347 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1165 k072-0275 30.3 µM 0.028935167642723 0.477035286303877 no 1564 0.488458148816751 2354 6153523 YGL055W OLE1 SGTC_1563 conessine 56.1 µM 0.0288239658809011 0.477076825503742 no 1565 0.488502493404973 2345 441082 An anti-amoebic, histamine inhibitor. SGTC_2364 9055074 200 µM 0.0271013949909101 0.477720320013477 no 1566 0.48918943106435 2340 6470630 SGTC_3267 9137951 49.47 µM 0.0269058027418391 0.477793390398774 no 1567 0.489267432637761 2346 16643986 SGTC_2106 5357045 167.29 µM 0.0260979565922368 0.478095197711559 no 1568 0.489589603455995 2340 668842 SGTC_1091 telmisartan 47.6 µM 0.0250780358602801 0.478476252956344 no 1569 0.489996359758267 2325 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1068 loratadine 26.9 µM 0.0250735126057964 0.478477942945331 no 1570 0.48999816370848 2312 3957 A H1 histamine antagonist. SGTC_1185 1319-0113 81.3 µM 0.0244415605774675 0.478714058139495 no 1571 0.490250198835083 2329 4672763 SGTC_1393 3470-5649 58.2 µM 0.0240802280839403 0.478849065565393 no 1572 0.490394307226558 2329 4108395 SGTC_2696 st077691 74.316 µM 0.0238420880233048 0.478938044987194 no 1573 0.490489284096392 2339 757133 SGTC_2164 5685496 200 µM 0.0228838066459499 0.479296110903511 no 1574 0.490871478719355 2365 759046 SGTC_1374 2889-5571 141 µM 0.022737061671606 0.479350944270391 no 1575 0.490930006265617 2345 2853281 SGTC_3155 9099265 49.47 µM 0.0212822574068176 0.479894573749579 no 1576 0.491510248586395 2361 25236499 SGTC_145 3737-0113 38.366 µM 0.0210466096119931 0.479982633875604 no 1577 0.491604237402102 2364 6849351 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0208974485290603 0.48003837495656 no 1578 0.491663730979769 2375 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2872 9044037 25.97 µM 0.0197952732584101 0.480450266810129 no 1579 0.492103344269655 2344 6465195 SGTC_537 1334-0398 209 µM 0.0196968116487912 0.480487063735777 no 1580 0.492142617111604 2376 5846986 SGTC_2385 9074692 200 µM 0.0196101354042331 0.480519456390023 no 1581 0.492177189252708 2363 17046906 SGTC_2526 patulin 37.61 µM 0.0195361764929572 0.480547096423 no 1582 0.492206688938092 2338 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2685 mycophenolic acid 18.85 µM 0.0188140666989828 0.48081696925016 no 1583 0.4924947161032 2366 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3089 9117425 49.47 µM 0.0175316330099932 0.481296272538111 no 1584 0.493006248614089 2298 9401657 SGTC_797 k781-0471 270 µM 0.0175261116861434 0.481298336164715 no 1585 0.493008450965242 2308 23738129 SGTC_791 1348-1292 225 µM 0.0168122415599454 0.481565153439103 no 1586 0.49329320196262 2367 5437054 SGTC_1947 st076332 61.6 µM 0.0163751501604404 0.481728525524348 no 1587 0.49346755219551 2376 24208416 SGTC_2813 7971799 71.43 µM 0.0161951440494649 0.481795807480323 no 1588 0.493539354721949 2355 2234054 SGTC_3228 9131799 49.47 µM 0.0160263522676544 0.481858898260805 no 1589 0.493606684161764 2347 17015818 SGTC_3026 9090633 49.47 µM 0.0152574173539112 0.482146315513933 no 1590 0.493913407277131 2374 25236842 SGTC_101 0490-5701 117.494 µM 0.0137561167125561 0.482707507572739 no 1591 0.494512276504107 2373 4661669 SGTC_204 PMA1.184 62.41 µM 0.0134578526060554 0.482819003978828 no 1592 0.494631255651469 2383 2252213 YGL008C PMA1 SGTC_117 lucigenin 22.078 µM 0.0134422292222952 0.482824844313521 no 1593 0.494637487916068 2358 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_3299 9121982 43.1275 µM 0.0132808551899157 0.482885169383923 no 1594 0.494701861093919 2376 17594604 YPL160W CDC60 SGTC_1171 0368-0077 21.4 µM 0.0128474725747225 0.483047179025045 no 1595 0.494874740987817 2377 3239779 SGTC_476 mead acid 10 µM 0.0125981228629585 0.483140393672857 no 1596 0.494974209079433 2380 5312531 An omega 9 fatty acid. SGTC_2251 lansoprazole 556 µM 0.0114809154323701 0.483558051666539 no 1597 0.495419878035265 2367 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_893 0958-0369 48.9 µM 0.0111885043147539 0.4836673699421 no 1598 0.495536525699493 2388 6819948 SGTC_457 grayanotoxin iii 135 µM 0.0109180718410991 0.483768472566095 no 1599 0.495644406056546 2362 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3074 9116018 49.47 µM 0.0108435370956724 0.483796337962314 no 1600 0.495674139357706 2376 17027303 SGTC_2146 5545642 200 µM 0.0107464485362825 0.483832635396551 no 1601 0.495712869832242 2379 825326 SGTC_2517 totarol 10 µM 0.0106283015687632 0.483876805887433 no 1602 0.495760000961124 2367 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_553 k007-0256 45.7 µM 0.0100180749484935 0.484104948688788 no 1603 0.496003433185384 2373 6287000 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.00866387829645741 0.484611254844953 no 1604 0.496543655875815 2390 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1290 0986-0249 10.2 µM 0.00811089368337486 0.48481801155035 no 1605 0.496764257055986 2392 53329 SGTC_3029 9088683 49.47 µM 0.00790002055652232 0.484896856473146 no 1606 0.496848380566262 2373 25236615 SGTC_1005 4092-0690 4.4 µM 0.00722807461658615 0.485148099265172 no 1607 0.497116440538193 2385 1529343 SGTC_53 0973-0023 39.979 µM 0.00693044013624174 0.485259387664225 no 1608 0.497235176540753 2393 674768 SGTC_1681 tripelennamine 100 µM 0.00605594436045081 0.485586376668184 no 1609 0.49758404251419 2396 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1377 2944-0135 198 µM 0.00526365636048755 0.485882635145584 no 1610 0.4979001146249 2393 1894137 SGTC_1627 st003713 25.6 µM 0.00522942353856183 0.485895435924803 no 1611 0.497913771356983 2388 16195070 YER133W GLC7 SGTC_490 phenamil 164 µM 0.00480217759449844 0.486055198468543 no 1612 0.498084215682849 2394 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2147 5545932 89.7195 µM 0.00472524492208346 0.486083966585665 no 1613 0.498114907030372 2392 797404 SGTC_1352 1496-0991 99 µM 0.00465279958475565 0.486111056779955 no 1614 0.498143808220717 2395 3000039 SGTC_2424 5537928 59.2 µM 0.00444733996581531 0.486187886655137 no 1615 0.498225773901006 2394 5382802 SGTC_1369 1866-0067 208 µM 0.00379972258081921 0.486430061003802 no 1616 0.498484133656368 2377 3531355 SGTC_3213 9129884 49.47 µM 0.00369466153719731 0.486469348702766 no 1617 0.498526046654412 2398 17190742 SGTC_1724 st037281 8.293 µM 0.0023768136730516 0.486962170468752 no 1618 0.499051789425962 2397 574124 YDL195W SEC31 SGTC_849 0386-0493 241 µM 0.00042375378854552 0.487692572219884 no 1619 0.499830946702328 2404 726119 SGTC_1953 st076800 12.1 µM -0.000326361499724052 0.487973110064978 no 1620 0.499869800601376 2406 297591 SGTC_2762 leflunomide 42.06 µM -0.000416261323690471 0.488006732369293 no 1621 0.49983393576308 2407 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1000 4048-0884 8.67 µM -0.000782194387508582 0.488143591276671 no 1622 0.49968794961915 2409 13040088 SGTC_1494 4358-1428 177 µM -0.00276717122732303 0.488885996211067 no 1623 0.498896059809166 2409 1564571 SGTC_2963 9082507 9 µM -0.00298621976879684 0.488967925375588 no 1624 0.498808672446269 2416 16459611 SGTC_2367 9070478 135.38 µM -0.00313533062782079 0.489023696513791 no 1625 0.498749186098837 2417 572802 SGTC_3208 9114115 49.47 µM -0.00320083798227731 0.489048197947625 no 1626 0.49872305257662 2419 650895 SGTC_3109 9122853 49.47 µM -0.00493900487608735 0.489698331839803 no 1627 0.498029630142614 2431 1234709 SGTC_1539 benzyladenosine 56 µM -0.00515849991653908 0.489780432477532 no 1628 0.497942065406831 2416 92208 A nucleotide analog. SGTC_2614 arthonioic acid 13.39 µM -0.00708352681356555 0.490500493955431 no 1629 0.497174105291913 2421 6710684 SGTC_2837 9008476 45.46 µM -0.00744187415816966 0.490634538229869 no 1630 0.497031149156136 2433 2992805 SGTC_1731 st035964 63 µM -0.00767988578321277 0.490723570019504 no 1631 0.496936198969946 2438 6739575 SGTC_518 1021-0119 62.6 µM -0.00768575903732405 0.490725767003452 no 1632 0.496933855949708 2432 1097762 SGTC_2656 pseudo-anisatin 100 µM -0.0092036938767448 0.491293583871401 no 1633 0.496328309213687 2420 6708809 A neurotoxin. SGTC_2797 7859098 81.82 µM -0.00926579579571313 0.491316814841768 no 1634 0.496303535188914 2427 972681 SGTC_811 0416-0114 265 µM -0.00943350755457957 0.491379552291609 no 1635 0.49623663080178 2443 6612453 SGTC_1661 st013063 9.66 µM -0.00963107017826364 0.491453456597059 no 1636 0.496157818299005 2424 721395 SGTC_1830 st055982 50.3 µM -0.00987338455994485 0.49154410205842 no 1637 0.49606115344405 2417 455313 An antimicrobial agent. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0101332761671754 0.491641323329617 no 1638 0.495957476881307 2435 1609 A potent and irreversible inhibitor of serine proteases. SGTC_990 3985-0011 41.3 µM -0.0104184182595456 0.491747990972329 no 1639 0.495843727650846 2437 5399565 YGL099W LSG1 SGTC_1133 3473-0247 50 µM -0.0109070479646282 0.491930781834228 no 1640 0.495648803685113 2455 711311 SGTC_919 tnp00227 403.569 nM -0.0110406004393348 0.491980742605291 no 1641 0.495595527164344 2439 1269246 A methoxyflavone. YNL221C POP1 SGTC_484 loperamide 105 µM -0.0118052437649428 0.492266791145532 no 1642 0.495290498520961 2423 3955 An opioid-receptor agonist. SGTC_923 1900-2434 73.3 µM -0.0123539278124064 0.492472053057814 no 1643 0.495071621228067 2430 5910570 SGTC_1334 1486-0610 236 µM -0.0139640420613509 0.493074405785505 no 1644 0.494429334258514 2493 3742339 SGTC_639 0833-0042 114 µM -0.0139986909281319 0.493087368298464 no 1645 0.494415512711563 2443 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3344 9148862 3.898 µM -0.0142865882758543 0.493195074067349 no 1646 0.494300669773224 2445 4905352 SGTC_1028 k015-0029 4.8 µM -0.014612548136699 0.493317020066479 no 1647 0.494170644178327 2427 4588309 SGTC_1289 0976-0073 69.1 µM -0.0156281093183041 0.493696959213155 no 1648 0.493765540213017 2461 3391136 SGTC_2798 7813637 45.45 µM -0.0165576592335993 0.494044725065837 no 1649 0.493394751480123 2456 956368 SGTC_2117 5521686 200 µM -0.0181429021985688 0.494637810961144 no 1650 0.492762426285186 2440 803312 SGTC_1523 st012844 44.7 µM -0.0182847088694014 0.494690865593461 no 1651 0.492705862991603 2490 4274103 SGTC_3329 9141233 27.5565 µM -0.0187388393420718 0.494860771663905 no 1652 0.492524722186641 2447 4909101 YNL103W MET4 SGTC_2114 5491910 81.25 µM -0.0187396331382075 0.494861068651588 no 1653 0.492524405563398 2470 2849228 SGTC_151 3013-0144 2.285 µM -0.0196138278982131 0.495188138043685 no 1654 0.49217571644401 2467 906558 YHR107C CDC12 SGTC_1446 4239-0190 62 µM -0.0199195896508445 0.495302535878624 no 1655 0.492053758981737 2451 1340085 SGTC_2839 9003951 25.97 µM -0.0203264789569721 0.495454770217816 no 1656 0.491891466497602 2438 2990634 SGTC_329 k048-0121 21.3 µM -0.020906087088992 0.495671627044751 no 1657 0.491660285445702 2472 6832902 SGTC_374 0880-0231 82.3 µM -0.0211096623158516 0.495747793773831 no 1658 0.491579088599917 2448 6833587 SGTC_2447 5741742 33.78 µM -0.0216521784095627 0.495950774409238 no 1659 0.491362705459744 2468 1776504 SGTC_391 gliotoxin 8.33 µM -0.0226153410745175 0.496311141143036 no 1660 0.490978553274876 2477 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1567 st069303 68.4 µM -0.0227346787198378 0.496355791467072 no 1661 0.490930956680154 2465 5581319 SGTC_2557 derrustone 83.84 µM -0.0227826822436845 0.496373752056365 no 1662 0.490911811003851 2494 629853 An antioxidant. SGTC_1738 st035555 74 µM -0.0229679665250921 0.496443076512318 no 1663 0.490837912607533 2468 5331140 SGTC_1027 k015-0025 8.67 µM -0.0237023843500899 0.496717861333706 no 1664 0.490545002052452 2451 3598955 SGTC_379 3970-0972 5.9 µM -0.023911355751536 0.496796048954487 no 1665 0.490461658146809 2458 2898042 YBL034C STU1 SGTC_3082 9117008 49.47 µM -0.0247080999411964 0.497094155598224 no 1666 0.490143897117649 2474 41448529 SGTC_2432 5630864 12.22 µM -0.0251505425656097 0.497259698885892 no 1667 0.489967442888676 2487 5714970 SGTC_2168 5727979 200 µM -0.027169974977527 0.498015290510802 no 1668 0.489162081679256 2446 695210 SGTC_2322 7413319 38.22 µM -0.0273447823485436 0.49808069687908 no 1669 0.489092369529764 2493 1840400 SGTC_2337 9009472 200 µM -0.0276203507453192 0.498183804351806 no 1670 0.488982475154474 2462 5742383 SGTC_854 0422-0053 192 µM -0.0276574436290931 0.498197683142485 no 1671 0.488967682885886 2460 3596728 SGTC_24 0417-1663 219 µM -0.0283017188056855 0.498438747513106 no 1672 0.4887107548708 2472 4329390 SGTC_2753 fluvastatin 17.09 µM -0.0286533187333303 0.498570303681771 no 1673 0.488570543659605 2486 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_112 phenothiazine 287.218 µM -0.0297484983521222 0.498980081815702 no 1674 0.488133816463674 2461 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_552 k242-0005 476 µM -0.0309577663947533 0.499432549103606 no 1675 0.487651610524883 2504 4088318 SGTC_1056 3448-1962 115 µM -0.0317352085662691 0.499723442147043 no 1676 0.487341608321756 2497 715507 SGTC_591 4299-0174 154 µM -0.0317763617571405 0.499738840309918 no 1677 0.487325198849933 2501 5509088 SGTC_288 1315-0019 35.1 µM -0.0318269364983679 0.499757763705848 no 1678 0.48730503264741 2495 6811474 SGTC_421 streptovitacin 30 mM -0.0331217396353366 0.499757763705848 no 1679 0.486788753268741 2607 91467 include heat shock SGTC_2408 sulbentine 18.36 µM -0.0333311655270494 0.499679403465787 no 1680 0.486705250532194 2578 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_691 1548-0686 185 µM -0.0336072382070245 0.499576106221882 no 1681 0.486595175137845 2489 46495133 SGTC_222 nsc-310342 10.666 µM -0.0343328739674724 0.499304597531567 no 1682 0.486305855339762 2457 432556 SGTC_2709 st078560 56 µM -0.0358385371649442 0.498741229771673 no 1683 0.485705552289198 2482 17250903 SGTC_3167 9103034 49.47 µM -0.0366320651188329 0.498444319643969 no 1684 0.48538918820675 2466 5127859 SGTC_67 0335-0847 266 µM -0.0367930760857122 0.498384075127959 no 1685 0.4853249973977 2564 4552207 YOR254C SEC63 SGTC_1482 3346-2049 8.48 µM -0.0386834673154744 0.497676761806935 no 1686 0.484571377357117 2544 3826804 SGTC_393 acivicin 6.25 µM -0.0390695006985458 0.497532323454951 no 1687 0.4844174886561 2495 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_666 0272-0154 136 µM -0.040209904027376 0.497105631807294 no 1688 0.483962890872584 2498 6870312 SGTC_69 0096-0274 206.684 µM -0.0414351818043822 0.496647187363211 no 1689 0.483474482923264 2719 6741392 SGTC_2598 perillyl alcohol 100 µM -0.0414823702159006 0.496629531643215 no 1690 0.483455673642693 2521 10819 An apoptosis inducer. SGTC_1714 st033236 13.627 µM -0.0420467069727525 0.496418383464259 no 1691 0.483230732118683 2514 2916566 SGTC_367 0335-0881 7.1 µM -0.0420798431056974 0.496405985517874 no 1692 0.483217524403744 2491 23828853 SGTC_2652 actinonin 100 µM -0.0421777188584185 0.496369365141455 no 1693 0.483178512263179 2479 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1206 3978-0017 132 µM -0.0421938447233802 0.496363331625062 no 1694 0.483172084695762 2661 3873677 SGTC_680 0417-1641 114 µM -0.0426042550192127 0.49620977628541 no 1695 0.483008501778512 2482 2835990 SGTC_2541 muurolladie-3-one 83.07 µM -0.0432254134162704 0.495977370451087 no 1696 0.482760923520409 2621 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_463 ikarugamyin 104 µM -0.0432269725428595 0.495976787107014 no 1697 0.482760302099727 2483 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0457517243293205 0.495032168480233 no 1698 0.481754068444704 2543 6708760 SGTC_2344 7990960 76.95 µM -0.0459774153000516 0.494947729023889 no 1699 0.481664125424346 2506 140813 SGTC_2458 5808907 16.39 µM -0.0464525411007705 0.494769967387406 no 1700 0.48147477996802 2491 2731747 SGTC_3010 9080089 71.4286 µM -0.0480838492214279 0.494159644517532 no 1701 0.480824708885274 2497 17027233 SGTC_1281 0884-0031 11.8 µM -0.0483943223469085 0.494043488414522 no 1702 0.48070099205797 2502 1548255 SGTC_3043 9092303 49.47 µM -0.0488294654556236 0.493880690867681 no 1703 0.480527600069038 2514 25236084 SGTC_2178 5812956 200 µM -0.0491071341749273 0.493776808824299 no 1704 0.480416959009659 2474 5403383 SGTC_1791 st048313 56.1 µM -0.0494777106895829 0.493638168567054 no 1705 0.480269299866571 2502 1204976 SGTC_397 arbidol 50 µM -0.0494859515483629 0.493635085501824 no 1706 0.480266016261913 2615 131410 A RNA synthesis inhibitor. SGTC_363 0455-0021 3.06 µM -0.0495878016603059 0.493596981429413 no 1707 0.480225433769304 2506 4597466 SGTC_3284 9108171 64.8615 µM -0.0498324033087923 0.493505471519648 no 1708 0.480127972322744 2541 8687505 SGTC_99 0109-0120 622.8 µM -0.0500928013318182 0.493408052275588 no 1709 0.480024218121583 2499 759414 SGTC_2689 tacrolimus 100 µM -0.0505784710725938 0.49322635617913 no 1710 0.479830709229365 2546 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_717 1532-0246 73.2 µM -0.0509251023570853 0.493096677243663 no 1711 0.479692601334825 2514 9561992 SGTC_1148 3909-7663 27.7 µM -0.050979036571574 0.493076499870131 no 1712 0.479671112608005 2615 4084526 SGTC_1305 1181-0477 144 µM -0.0533025578483973 0.492207262913306 no 1713 0.478745421116323 2536 6252086 SGTC_2413 inermin 26.06 µM -0.0543408115161661 0.491818860514697 no 1714 0.47833181734134 2613 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_3280 9140961 49.47 µM -0.0544188838961163 0.491789654570345 no 1715 0.478300716986551 2505 4901226 SGTC_1707 st032323 6.317 µM -0.0545049780857787 0.491757447813879 no 1716 0.478266421274232 2522 3132057 YMR211W DML1 SGTC_2807 7945238 51.95 µM -0.0556788900652643 0.491318307516578 no 1717 0.477798808348633 2558 17148797 SGTC_528 3492-0019 172 µM -0.0559735124726923 0.491208095968162 no 1718 0.477681454027707 2502 2869262 SGTC_2852 9023854 51.95 µM -0.0575470831352181 0.490619470508806 no 1719 0.477054700652915 2572 19798528 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.0592852469335127 0.489969299504571 no 1720 0.476362455843535 2499 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2603 homopterocarpin 100 µM -0.0592989807280636 0.489964162396957 no 1721 0.476356986474606 2568 101795 A weak amylase inhibitor. SGTC_2655 perillic acid 100 µM -0.0595467381198504 0.489871489360292 no 1722 0.476258319929406 2509 5702197 An apoptosis inducer. SGTC_767 0929-0023 86 µM -0.0601135658991334 0.489659470902684 no 1723 0.476032592739171 2520 1204563 SGTC_273 hydroxyurea 18.1 mM -0.0606779202039626 0.489448380535709 no 1724 0.475807858198822 2504 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2345 9052315 157.45 µM -0.0608069832106887 0.489400106385793 no 1725 0.475756464408581 2567 6469265 SGTC_1193 1488-0126 41.5 µM -0.0620823683909366 0.488923075477376 no 1726 0.475248618948271 2555 1384710 SGTC_310 1273-0058 1.06 µM -0.0638600322455636 0.488258204415787 no 1727 0.474540838467879 2524 2734232 SGTC_1753 st043925 64 µM -0.064428798417671 0.488045484740835 no 1728 0.474314399918103 2514 670181 SGTC_426 0988-0037 14.6 µM -0.0657165818289829 0.487563863855413 no 1729 0.47380173528021 2507 5383008 SGTC_3188 9110789 49.47 µM -0.0659734506147794 0.48746779909334 no 1730 0.47369948136606 2558 849217 SGTC_2688 kanamycin b 96.69 µM -0.0660509434162829 0.487438818184244 no 1731 0.473668633495891 2555 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1781 st038725 66.3 µM -0.0674245060228902 0.486925141710081 no 1732 0.473121880295575 2533 4270275 YIL048W NEO1 SGTC_1090 efavirenz 20.7 µM -0.0674890042814828 0.486901021575579 no 1733 0.473096207690202 2557 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2888 9058547 12.99 µM -0.0680079084777027 0.486706970971079 no 1734 0.472889669403689 2545 16476514 SGTC_2766 oltipraz 83.91 µM -0.0680354831821546 0.486696659158961 no 1735 0.472878694108684 2562 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2354 9060492 162 µM -0.0686118934716254 0.486481107323062 no 1736 0.472649275778809 2569 6471895 SGTC_3062 9077494 49.47 µM -0.0697680982608151 0.486048750077336 no 1737 0.472189119591069 2551 16459633 SGTC_1741 st038134 10.228 µM -0.0707329448782692 0.485687962834769 no 1738 0.471805150136753 2610 1272587 SGTC_2720 fluspirilene 36.88 µM -0.0711669034577155 0.485525695539355 no 1739 0.471632460909711 2593 3396 An atypical antipsychotic. SGTC_3251 9135047 49.47 µM -0.0716276349101968 0.485353419862171 no 1740 0.471449123538583 2629 17682963 SGTC_144 4161-2749 112.381 µM -0.0720531820691952 0.485194302645321 no 1741 0.471279792313087 2523 797501 YMR168C CEP3 SGTC_1337 1486-1011 40.3 µM -0.0724950978847516 0.485029067485817 no 1742 0.471103953263713 2537 X1337 SGTC_1014 4130-3005 69.3 µM -0.0729722244913361 0.484850669672413 no 1743 0.4709141101065 2546 743608 SGTC_1730 st033808 45.1 µM -0.0746238886788196 0.484233135468659 no 1744 0.470256983348619 2558 1045166 SGTC_2961 9083290 32.55 µM -0.0747082613653152 0.484201590700591 no 1745 0.470223417213189 2521 17741490 SGTC_1034 k072-0165 12.7 µM -0.0747096432282999 0.484201074058538 no 1746 0.470222867465948 2549 5835461 SGTC_1214 0358-0031 63.7 µM -0.0751266846536604 0.484045154506208 no 1747 0.470056958265708 2753 4301366 SGTC_1413 3910-0535 34.4 µM -0.0755397950539741 0.483890707054006 no 1748 0.46989261804729 2639 2876951 SGTC_1252 0493-0875 34.8 µM -0.0763989751607024 0.483569497591607 no 1749 0.469550842463915 2551 3960963 SGTC_723 4182-0001 115 µM -0.0766131661128533 0.48348942271515 no 1750 0.469465642348165 2565 744821 YLR208W SEC13 SGTC_1109 tnp00067 928.257 nM -0.0780882870776498 0.482937969830527 no 1751 0.468878912150684 2567 676295 SGTC_1221 2958-7315 257 µM -0.0781168434897919 0.482927294742724 no 1752 0.468867554484329 2613 4562705 SGTC_1899 st063254 59.6 µM -0.0782142181577659 0.482890893793748 no 1753 0.468828826105448 2534 3093813 SGTC_728 3030-5151 22.5 µM -0.0785061872408476 0.48278174971599 no 1754 0.468712704354318 2547 3125388 SGTC_3161 9100388 49.47 µM -0.07899600279884 0.482598649439048 no 1755 0.468517901216814 2553 25236368 SGTC_235 0330-0087 5 mM -0.0807229150896056 0.481953133703858 no 1756 0.467831156338873 2560 46494818 YHR062C RPP1 SGTC_3300 9124615 50.48 µM -0.081507163131166 0.481659999158031 no 1757 0.467519314239981 2677 24824903 SGTC_2589 lobaric acid 100 µM -0.0817463549196671 0.481570596531853 no 1758 0.467424207894368 2587 73157 A novel microtubule depolymerizer. SGTC_828 2074-0507 139 µM -0.0843211220870514 0.48060828637332 no 1759 0.466400559603978 2644 X828 SGTC_802 4112-3352 742 µM -0.0847909406448423 0.480432705368068 no 1760 0.466213797960622 2695 704594 SGTC_254 nsc-64875 3.808 µM -0.0861415206708761 0.479927986671633 no 1761 0.465676958775222 2708 56993 SGTC_1559 coumarin 343 70.1 µM -0.0899778696046887 0.478494501585258 no 1762 0.464152400489826 2645 108770 A hepatotoxic, DNA x-linker. SGTC_2481 5478948 45.16 µM -0.0901644710397772 0.478424783282933 no 1763 0.464078258648249 2667 77792 SGTC_22 0964-0034 14.468 µM -0.0908486714599827 0.478169156981191 no 1764 0.463806417844551 2592 138402 SGTC_2193 5925765 200 µM -0.0908879520476628 0.478154481507111 no 1765 0.463790811720784 2643 877370 SGTC_472 calcifediol 10 µM -0.0918548966397114 0.477793234327434 no 1766 0.463406663582657 2638 5283731 A vitamin D metabolite. SGTC_715 0868-0130 184 µM -0.0924636345235042 0.477565821284044 no 1767 0.463164841428175 2625 2876258 SGTC_152 4469-0003 551.229 µM -0.0937516482488807 0.477084667711687 no 1768 0.462653220771868 2575 697280 SGTC_368 fentichlor 4.58 µM -0.094560692986262 0.476782456008064 no 1769 0.462331886167105 2648 7329 A pesticide. SGTC_1922 5578187 25 µM -0.0946459828565361 0.476750597485572 no 1770 0.462298012353222 2742 1350412 SGTC_3187 9109394 49.47 µM -0.0958591450649554 0.47629745838675 no 1771 0.461816221307211 2618 17098090 SGTC_1382 3002-2117 298 µM -0.0963952911741731 0.476097207375418 no 1772 0.46160331590422 2604 1497314 SGTC_1950 st077106 7.18 µM -0.0981878535892499 0.475427727962687 no 1773 0.460891563644422 2650 13831864 SGTC_706 4262-0057 46.9 µM -0.0982726867884545 0.475396046485418 no 1774 0.460857882982591 2562 883298 SGTC_43 0570-0105 72.5 µM -0.0993433694199274 0.474996206943783 no 1775 0.460432822443515 2597 1114046 YDL195W SEC31 SGTC_535 2293-4129 48.2 µM -0.100700329946425 0.474489494995194 no 1776 0.459894174723667 2573 396118 YIL048W NEO1 SGTC_2029 5175081 200 µM -0.100724435740461 0.474480493855716 no 1777 0.459884606551388 2578 1380876 SGTC_232 clozapine 119 µM -0.101968578476842 0.474015946891852 no 1778 0.459390807896807 2590 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1160 4092-0570 10.5 µM -0.102018082006855 0.473997463634417 no 1779 0.459371161300107 2588 4994975 SGTC_2690 usnic acid 100 µM -0.102575712836972 0.473789263485513 no 1780 0.459149859744813 2684 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1112 tnp00069 1.16933 µM -0.10367453868807 0.473379020759374 no 1781 0.458713816465959 2715 145826 SGTC_3311 9131146 2.8755 µM -0.103868297794254 0.473306684401436 no 1782 0.458636932843769 2647 4900406 YPR165W RHO1 SGTC_2214 7179297 48.276 µM -0.104357973640203 0.473123876962018 no 1783 0.458442636348652 2588 769744 SGTC_1031 k035-0009 16 µM -0.104945028218098 0.472904723229717 no 1784 0.4582097144316 2762 5180959 SGTC_2104 5389443 200 µM -0.105279017673105 0.4727800450617 no 1785 0.458077205955472 2711 2244536 SGTC_423 5-fluorouracil 457 µM -0.105436511121486 0.472721253726987 no 1786 0.458014722913196 2570 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_555 4296-0685 37 µM -0.10567311233549 0.472632933067753 no 1787 0.45792085706295 2576 2908540 YHR072W ERG7 SGTC_550 4123-0385 25.7 µM -0.105707916089334 0.472619941318484 no 1788 0.457907049707215 2604 5731123 SGTC_1740 st038286 13.222 µM -0.105895455242335 0.472549936105724 no 1789 0.457832649992556 2724 716786 SGTC_1956 st077085 54 µM -0.106238072769375 0.472422044934303 no 1790 0.457696732079066 2630 24208685 SGTC_741 4582-0002 126 µM -0.106337562175559 0.472384908379994 no 1791 0.457657265110457 2595 2912688 SGTC_1798 st045719 60.953 µM -0.107182310497885 0.472069597658831 no 1792 0.457322174379113 2594 3980186 SGTC_2316 5844804 197.44 µM -0.109296887825771 0.47128038779963 no 1793 0.456483507482114 2692 776813 SGTC_2826 7992541 19.48 µM -0.110408863355496 0.470865417495131 no 1794 0.456042562082367 2580 2985066 SGTC_783 0848-0141 92.7 µM -0.112464711002989 0.470098293851551 no 1795 0.455227474364671 2595 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2457 5731572 11.68 µM -0.113012960131881 0.469893737554996 no 1796 0.455010140171335 2712 2865357 SGTC_1139 k015-0024 46.9 µM -0.114750011749032 0.46924568191286 no 1797 0.454321636033315 2584 2766652 SGTC_1745 st081495 74 µM -0.116094220615622 0.468744243060984 no 1798 0.453788934562084 2630 13842402 YBL026W LSM2 SGTC_3321 9137793 26.8275 µM -0.118276554112678 0.467930259137233 no 1799 0.452924267046176 2612 4904192 SGTC_1540 guanosine 70.6 µM -0.118881670615652 0.46770458161707 no 1800 0.45268455174953 2594 6802 Guanosine is a purine nucleoside SGTC_2034 5197015 53.07 µM -0.11976983968294 0.467373358779237 no 1801 0.452332737184662 2746 780676 SGTC_1421 4029-0249 71.4 µM -0.119883859503698 0.46733083926227 no 1802 0.452287575252242 2720 2894095 SGTC_643 k048-0106 28.4 µM -0.119969618465632 0.467298858843344 no 1803 0.452253607525917 2737 6763920 SGTC_2835 9006588 71.43 µM -0.120410601253119 0.467134415061478 no 1804 0.452078946959212 2848 2345538 SGTC_1675 st018485 24.5 µM -0.122839135155929 0.466228908865169 no 1805 0.451117241774897 2703 3323024 SGTC_994 3910-0338 138 µM -0.123200079912456 0.46609434135699 no 1806 0.450974331145284 2758 3479481 SGTC_2787 5284540 71.43 µM -0.1234326081296 0.46600765218493 no 1807 0.450882268471127 2693 736958 SGTC_1596 piperlongumine 63 µM -0.12450952965308 0.465606184651958 no 1808 0.450455927761313 2778 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1380 2291-0730 164 µM -0.12534722211789 0.465293923935781 no 1809 0.45012433455532 2699 2999191 SGTC_1450 4112-4260 37.6 µM -0.125354438484924 0.465291234034063 no 1810 0.450121478170727 2604 1633175 SGTC_2256 7954252 200 µM -0.126402070372415 0.464900746006313 no 1811 0.449706831689347 2705 2972920 SGTC_3207 9114163 49.47 µM -0.126756765119425 0.464768546853274 no 1812 0.449566458033279 2791 849233 SGTC_1009 4106-0057 9.87 µM -0.126833314945292 0.464740016288785 no 1813 0.449536163574331 2615 2928005 SGTC_155 k072-0202 43.6 µM -0.128421070113943 0.464148291810468 no 1814 0.448907878836853 2608 5857737 SGTC_2671 danthron 100 µM -0.129768276984179 0.46364627698316 no 1815 0.44837488097204 2669 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2372 9071633 200 µM -0.130362898464677 0.463424719279919 no 1816 0.448139659392954 2619 21321366 SGTC_1718 roemerine 11.9335 µM -0.130991874487321 0.463190373321039 no 1817 0.447890867619084 2695 235224 An aporphine alkaloid with mutagenic activity. SGTC_2038 4100038 30.985 µM -0.132052438656041 0.4627952537981 no 1818 0.447471407412578 2728 3596803 SGTC_549 1661-1316 519 µM -0.132116107984213 0.462771534573193 no 1819 0.447446227632835 2687 2857282 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.137355276716267 0.460820208088431 no 1820 0.445374989961859 2636 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2705 st078069 42.8 µM -0.137359665531914 0.460818573864417 no 1821 0.445373255517104 2716 1530061 SGTC_2516 gossypol 71.55 µM -0.13836945374372 0.460442585710158 no 1822 0.444974218573424 2773 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1813 st051246 8.6015 µM -0.138915304062254 0.46023935655429 no 1823 0.444758538666477 2680 5291959 SGTC_2820 7989630 71.43 µM -0.139943057564929 0.459856735055525 no 1824 0.444352490491849 2667 2984098 SGTC_3058 9093861 49.47 µM -0.140081775961997 0.459805094538089 no 1825 0.444297689642912 2797 17217477 SGTC_958 1222-0007 33 µM -0.141308793436478 0.459348343960969 no 1826 0.443813001582319 2791 7312461 SGTC_3008 9078912 71.4286 µM -0.141456329652974 0.459293428008841 no 1827 0.443754728479265 2677 16648731 SGTC_192 3455-0609 60.9 µM -0.141892802641486 0.459130968520947 no 1828 0.443582339727857 2770 3769639 SGTC_1161 k007-0610 110 µM -0.142324590164485 0.458970259724128 no 1829 0.443411812045958 2730 5843850 SGTC_2939 9044578 71.43 µM -0.142355170895905 0.458958878008269 no 1830 0.443399735064712 2666 2653634 SGTC_211 3455-0679 143.504 µM -0.143327924718377 0.45859685039418 no 1831 0.443015601385217 2716 748649 SGTC_3236 9132701 49.47 µM -0.143830308901787 0.458409892624396 no 1832 0.442817234334172 2699 24282524 SGTC_2427 5545055 42.75 µM -0.144498996322052 0.458161060875445 no 1833 0.442553224476616 2680 5372858 SGTC_750 4073-0104 132 µM -0.144979606818688 0.457982226372737 no 1834 0.442363486530644 2726 22330957 SGTC_206 4546-0025 72.014 µM -0.145165166869397 0.45791318200791 no 1835 0.442290233690544 2682 6620745 YIL048W NEO1 SGTC_618 k072-0232 33.2 µM -0.145341636586235 0.457847521210555 no 1836 0.44222057123771 2748 5872756 YGL099W LSG1 SGTC_2348 9022543 33.42 µM -0.146642545682949 0.457363514974328 no 1837 0.441707085036661 2776 3162678 YDL140C RPO21 SGTC_3015 9080845 49.47 µM -0.146975618073929 0.457239604759906 no 1838 0.441575632629195 2777 5296973 SGTC_2518 prenyletin 46.28 µM -0.148022537285131 0.45685015503778 no 1839 0.441162490993029 2710 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2219 9098279 200 µM -0.148490557733441 0.456676066700939 no 1840 0.440977818593152 2672 902349 SGTC_1265 0819-1001 68.8 µM -0.148773900722041 0.456570676392287 no 1841 0.440866022811212 2637 3106768 SGTC_1498 4478-3555 97.6 µM -0.149518764857163 0.456293636443574 no 1842 0.44057215179148 2673 3437919 SGTC_1317 1273-0028 910 nM -0.149567513328086 0.456275505991861 no 1843 0.440552920211417 2700 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_583 1488-1091 88.9 µM -0.149759392347684 0.456204143544898 no 1844 0.44047722408735 2678 4303273 SGTC_897 1000-0139 31.4 µM -0.149765500460994 0.456201871876721 no 1845 0.440474814477106 2792 6151020 SGTC_1857 st056007 79.3 µM -0.151015292129322 0.455737092126975 no 1846 0.439981826434892 2747 619834 SGTC_504 lovastatin 124 µM -0.151233781500259 0.455655845238678 no 1847 0.439895651485961 2688 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3199 9111318 49.47 µM -0.15163898704915 0.455505171470115 no 1848 0.439735840874246 2781 8548020 SGTC_331 k048-0133 24.5 µM -0.154761462685772 0.454344309939927 no 1849 0.438504686707819 2682 6813582 SGTC_2198 6589944 200 µM -0.155828304218879 0.4539477727123 no 1850 0.438084179805397 2716 5290268 SGTC_3080 9117754 49.47 µM -0.15632677190787 0.453762511612668 no 1851 0.437887727412115 2858 9550191 SGTC_813 k007-0158 173 µM -0.156344914713145 0.453755768825392 no 1852 0.437880577392519 2766 6523916 SGTC_2282 7944268 200 µM -0.156825557946174 0.453577142265218 no 1853 0.437691164875766 2826 2970414 SGTC_2436 5633522 8.09 µM -0.157356719348557 0.453379752025164 no 1854 0.437481860700754 2752 5724242 SGTC_1889 st059080 5.18 µM -0.157629750876902 0.453278292506834 no 1855 0.437374279417927 2676 176925 Isolated from Daphnopsis sellowiana. SGTC_1440 4100-1550 40 µM -0.160462013911133 0.45222599427794 no 1856 0.436258571178587 2698 742806 SGTC_936 3005-4620 401 µM -0.161111811925337 0.451984615552455 no 1857 0.436002668604725 2872 777207 SGTC_2238 6671620 73.2395 µM -0.162678589463594 0.451402682060072 no 1858 0.435385752769563 2645 729941 SGTC_309 k408-0051 1.48 µM -0.163071038960086 0.451256934527558 no 1859 0.43523125105163 2726 3640463 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.163864488471006 0.450962284071153 no 1860 0.434918911626982 3089 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2819 7996655 46.38 µM -0.164368420755008 0.450775160944164 no 1861 0.434720561010884 2786 6456960 SGTC_635 k038-0028 24.7 µM -0.164463649045902 0.450739801437691 no 1862 0.434683080457537 2722 4035102 SGTC_3149 9097855 49.47 µM -0.165981332078025 0.450176318884686 no 1863 0.434085820613909 2830 25236625 YMR079W SEC14 SGTC_925 2064-1272 59.6 µM -0.167419513936204 0.449642446033607 no 1864 0.433519985983083 2731 6815817 SGTC_1929 genistein trimethyl ether 50.5 µM -0.167878100652922 0.44947223146552 no 1865 0.433339589375562 2728 136420 SGTC_269 exalamide 29 µM -0.170235428327238 0.448597404742044 no 1866 0.432412495283493 2740 3316 A derivative of salicylamide. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.170559298041504 0.448477233038887 no 1867 0.432285152166715 2951 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2066 5222451 176 µM -0.170864028461265 0.44836416727823 no 1868 0.432165340898097 2707 2281147 SGTC_1514 1189-1591 158 µM -0.17461578082423 0.446972480995302 no 1869 0.430690773897016 2918 767698 YMR146C TIF34 SGTC_1291 0993-0025 5.79 µM -0.176032919695864 0.446446972166087 no 1870 0.430134040040016 2836 4353356 SGTC_1053 3366-3204 134 µM -0.177126218754988 0.446041615059057 no 1871 0.429704623969496 2766 3632071 YPR165W RHO1 SGTC_2630 antimycin a 100 µM -0.177177762675056 0.44602250576228 no 1872 0.429684381065466 2672 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1406 3909-7906 11.9 µM -0.178557666982828 0.445510969360151 no 1873 0.429142518520865 2757 X1406 SGTC_769 0302-0231 76 µM -0.178778707331853 0.445429037167655 no 1874 0.429055732499553 2800 571869 YER009W NTF2 SGTC_1701 st028638 40.4 µM -0.179232631970848 0.445260789945235 no 1875 0.428877520983999 2811 3490878 SGTC_1800 st050079 29.0735 µM -0.179416874835917 0.445192503116232 no 1876 0.428805191084747 2801 3645560 SGTC_1269 0831-0796 3.05 µM -0.180112503452503 0.444934693577184 no 1877 0.428532123399268 2834 927758 SGTC_3126 9127922 49.47 µM -0.182859499006953 0.443916847829437 no 1878 0.427454131058743 2986 45595682 SGTC_1871 st057448 67.3 µM -0.183419196936077 0.44370950778783 no 1879 0.427234557198355 2905 691747 SGTC_2694 st077685 81.9 µM -0.184071018446259 0.443468059999747 no 1880 0.426978870954095 2712 2838096 SGTC_2642 cholecalciferol 100 µM -0.184792344587488 0.443200890765218 no 1881 0.426695956292238 2832 9821465 A vitamin D precursor, similar to steriods. SGTC_1654 st012436 41.8 µM -0.185221591150004 0.443041916016903 no 1882 0.426527617400224 2757 4323132 SGTC_3293 9120939 62.045 µM -0.185452197406687 0.44295651300992 no 1883 0.42643718538801 2882 934087 SGTC_2294 7971431 200 µM -0.18812929243154 0.441965269294785 no 1884 0.425387649507299 2864 5741572 SGTC_3229 9132204 49.47 µM -0.188231508443066 0.441927429096055 no 1885 0.425347586881735 2721 17682924 SGTC_2166 5933061 31.504 µM -0.189137233195456 0.441592154479006 no 1886 0.424992630117024 3253 2877375 SGTC_789 1309-1135 70.6 µM -0.189709521535754 0.441380330491996 no 1887 0.424768379601125 2722 3092424 SGTC_65 0798-0905 34.986 µM -0.19035926855266 0.441139856658926 no 1888 0.424513806508266 3149 3602145 SGTC_2082 5219693 150 µM -0.190618742570764 0.441043830399722 no 1889 0.424412152496257 2737 2834649 SGTC_137 0438-0332 85.389 µM -0.191135286563321 0.440852677894473 no 1890 0.424209801276748 2732 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_815 1582-0027 36.9 µM -0.191806654096824 0.440604251920218 no 1891 0.423946829264443 2838 3128206 SGTC_2912 7964298 10.93 µM -0.192719255796519 0.44026659962387 no 1892 0.423589421101443 2835 2975850 SGTC_503 tyrphostin 8 294 µM -0.193382220920141 0.440021337257057 no 1893 0.423329819140038 2851 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2249 haloperidol 116.36 µM -0.193610876253107 0.439936752094622 no 1894 0.423240290660564 2729 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1219 1469-0211 33.1 µM -0.194557682007456 0.439586534865114 no 1895 0.422869617378807 2829 6822282 SGTC_696 1560-0013 611 µM -0.194893111147107 0.43946247315624 no 1896 0.422738313647621 2946 1650269 SGTC_360 0957-0399 1.01 µM -0.195026386855791 0.439413181497162 no 1897 0.422686145255615 2902 6752301 YPR165W RHO1 SGTC_50 0929-0078 56.389 µM -0.195204526121218 0.439347298640405 no 1898 0.422616417944489 2801 1377751 SGTC_1524 corynanthine 62.1 µM -0.195519119918623 0.439230953673399 no 1899 0.422493285493107 2946 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2468 5987765 72.9 µM -0.195533444227972 0.439225656296186 no 1900 0.422487679118619 2796 26772094 SGTC_623 k072-0108 16.9 µM -0.196480855300038 0.438875311515557 no 1901 0.42211690793868 2842 5382803 SGTC_1192 1488-0095 21.4 µM -0.197461938641206 0.438512565477012 no 1902 0.421733031788916 2828 915875 SGTC_2679 rapamycin 1 nM -0.197523265024074 0.438489892354426 no 1903 0.421709038601257 2822 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_468 gf-109203x 121 µM -0.198038928967344 0.438299253006328 no 1904 0.421507302975753 2846 2396 A protein kinase C inhibitor. SGTC_1396 3511-0007 98.6 µM -0.198758647367332 0.438033199308418 no 1905 0.421225772576816 2885 X1396 SGTC_1906 st060206 94.7 µM -0.198808855844433 0.438014640105495 no 1906 0.421206134156736 2893 5133468 SGTC_1012 4112-3522 18 µM -0.199245143164338 0.437853375375571 no 1907 0.421035494066524 2900 3112398 SGTC_2004 4023728 41.89 µM -0.200582913480092 0.437358960256579 no 1908 0.420512359802845 2874 360084 YDR527W RBA50 SGTC_2479 5617353 43.85 µM -0.201010055078358 0.437201117199159 no 1909 0.420345355861071 2909 2731746 SGTC_2074 5212007 75.395 µM -0.201091479879463 0.437171029154733 no 1910 0.420313521995778 2785 758611 SGTC_825 1988-2224 89.6 µM -0.201308848845082 0.437090708883235 no 1911 0.420228541911715 2756 1180859 SGTC_952 1185-0122 232 µM -0.201354663101838 0.437073780332099 no 1912 0.42021063136835 2718 678600 SGTC_582 0987-0078 156 µM -0.201403243292679 0.437055829883113 no 1913 0.42019163969616 2782 1625765 SGTC_2231 micatex 6.853 µM -0.203579874982785 0.436251694920652 no 1914 0.419340910613335 2788 20737 An antifungal of unknown mechanism. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.205265760148284 0.435629042235291 no 1915 0.4186822469468 2742 6708784 An antioxidant flavonoid SGTC_3218 9131285 49.47 µM -0.205277672663807 0.435624643118433 no 1916 0.41867759361816 2883 17156417 SGTC_650 1328-0195 38 µM -0.205776631684824 0.435440392047994 no 1917 0.418482697883427 2790 2780821 SGTC_1422 4031-0024 15.5 µM -0.206347865644068 0.435229469151362 no 1918 0.418259595788755 2784 782427 SGTC_441 propafenone 146 µM -0.206426267699752 0.435200521348701 no 1919 0.418228977000881 2747 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3339 9145883 14.936 µM -0.207345251914403 0.434861237636223 no 1920 0.417870118013018 2922 2030670 SGTC_2266 7929956 200 µM -0.208480768953653 0.434442077511143 no 1921 0.417426798449285 2746 2967153 SGTC_193 1273-0060 1.558 µM -0.208506246453541 0.434432673694268 no 1922 0.417416852927274 2763 2847393 YHR072W ERG7 SGTC_1101 ebselen 5.29 µM -0.208843898634857 0.434308048830243 no 1923 0.417285050355367 2916 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2602 kawain 100 µM -0.209272276728379 0.434149947115505 no 1924 0.417117846289262 2723 5369129 SGTC_1115 galangin 695.678 nM -0.209986843378336 0.433886245099087 no 1925 0.416838970789391 2790 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1829 berberine 14.4 µM -0.210857240911198 0.433565075372972 no 1926 0.416499335365264 2933 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2160 5660466 132.927 µM -0.211641016941604 0.433275905813722 no 1927 0.416193553603963 2741 2859134 SGTC_2867 9039098 71.43 µM -0.211756133634609 0.433233437191155 no 1928 0.416148646335691 2760 6463460 SGTC_1765 st044815 90.4 µM -0.212830521175957 0.432837113506664 no 1929 0.415729578317361 2863 645695 SGTC_2926 9010726 65.15 µM -0.214946027571891 0.432056936220347 no 1930 0.41490469933674 2905 2994293 SGTC_2955 9076254 12.21 µM -0.21628818223569 0.431562100345298 no 1931 0.414381560135983 2886 16459619 SGTC_1024 4507-0395 26 µM -0.216652309180977 0.431427869715734 no 1932 0.414239658468456 2960 4201836 SGTC_2295 7971645 200 µM -0.216757283155221 0.431389173904718 no 1933 0.414198751785911 2859 2978226 YKL099C UTP11 SGTC_1820 st053765 18.6 µM -0.217689316431495 0.431045634012974 no 1934 0.413835594160599 2846 3690829 SGTC_38 0929-0051 58.268 µM -0.217928051558259 0.430957646566941 no 1935 0.413742585200444 2923 1379719 SGTC_1804 st050076 49.1 µM -0.217993736462785 0.430933438551939 no 1936 0.413716995828 2900 3895976 SGTC_460 trequinsin 123 µM -0.218747142273597 0.430655791215976 no 1937 0.413423511973395 2856 5537 A vasodilator. SGTC_2582 agaric acid 100 µM -0.219546364060589 0.430361297107056 no 1938 0.413112233700673 2910 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2677 mitomycin C 100 µM -0.219711500653923 0.430300453045481 no 1939 0.413047923645274 2811 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1453 4237-0541 195 µM -0.220332497135807 0.430071663657152 no 1940 0.412806106455101 2909 739892 SGTC_760 0568-0725 82.9 µM -0.221337103128722 0.429701593444004 no 1941 0.412414981096399 2947 3916171 SGTC_2102 5377816 72.7585 µM -0.222248158654298 0.429366038134428 no 1942 0.412060353117265 2987 1379702 SGTC_731 3966-0296 387 µM -0.227787528121074 0.427326912934559 no 1943 0.409905711476574 2818 660956 SGTC_3048 9093155 49.47 µM -0.227963602436697 0.427262128857712 no 1944 0.409837268291734 2859 25236002 SGTC_976 1348-1067 47.6 µM -0.229581301692513 0.42666701110409 no 1945 0.409208568947486 2831 5310671 YGL099W LSG1 SGTC_647 0140-0236 81 µM -0.229899233281227 0.426550070298077 no 1946 0.409085036062309 2845 990837 SGTC_58 0957-0393 9 µM -0.235512701724673 0.424486410863068 no 1947 0.406905410763747 2858 6997992 SGTC_1801 st050089 28.441 µM -0.235636483113744 0.424440928651629 no 1948 0.406857380524818 2816 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_3248 9135562 49.47 µM -0.236087588542675 0.424275183072614 no 1949 0.406682352327578 2876 17650701 SGTC_892 0929-0076 29 µM -0.236130322478201 0.424259482423941 no 1950 0.406665772593765 2842 5751038 SGTC_3336 9143619 71.43 µM -0.236137617430909 0.424256802236054 no 1951 0.4066629423452 2855 45595730 SGTC_438 sphingosine 6.67 µM -0.236911334628464 0.423972556087941 no 1952 0.406362788260534 2806 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1949 st076024 69.1 µM -0.23718021660671 0.423873784200654 no 1953 0.406258491671837 2757 2921930 SGTC_812 4251-0442 148 µM -0.239498188259275 0.423022492708156 no 1954 0.405359650575802 2877 5723007 SGTC_350 k064-0020 19.8 µM -0.240173450444254 0.422774565296286 no 1955 0.405097897427804 3018 2790705 SGTC_1987 st072290 61.9 µM -0.24056674774237 0.422630177427677 no 1956 0.404945462412193 2888 54697379 SGTC_2893 9048488 25.97 µM -0.24062453718423 0.42260896256025 no 1957 0.404923065470292 2871 6467338 SGTC_3072 9116419 49.47 µM -0.240750663252382 0.422562661667361 no 1958 0.404874184989384 2906 17170162 SGTC_1244 0416-0015 52.5 µM -0.242207012431012 0.422028113389494 no 1959 0.404309880833564 2858 96201 SGTC_1310 1188-0297 994 nM -0.242277480907783 0.422002251796666 no 1960 0.404282580844943 2883 1588352 SGTC_1817 st052116 64.4 µM -0.243015384649962 0.421731464885213 no 1961 0.403996739709727 2985 4361398 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.243129070748886 0.421689749034377 no 1962 0.403952705776578 2816 3256 An antibiotic and ribosome inhibitor. SGTC_1568 digitonin 820 nM -0.244508083670936 0.421183805680704 no 1963 0.40341867103749 2983 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_216 k038-0035 28.382 µM -0.244614474027657 0.421144777726858 no 1964 0.40337747791563 2905 4444231 YPR107C YTH1 SGTC_2002 4023503 131 µM -0.244616379061209 0.421144078896507 no 1965 0.403376740318328 2910 4736863 YCR052W RSC6 SGTC_1375 2910-0797 186 µM -0.245759295601947 0.420724863547679 no 1966 0.402934284098526 2911 742508 SGTC_315 k915-0449 187 µM -0.24722296140462 0.420188130499011 no 1967 0.402367838051755 2875 20970215 YNL149C PGA2 SGTC_1351 1496-0003 46.5 µM -0.249059235590187 0.419514970192999 no 1968 0.401657480646442 2968 3891978 SGTC_2950 9072895 21.46 µM -0.249882232689092 0.419213343739071 no 1969 0.401339211851652 2976 17332245 SGTC_981 1488-1094 54.9 µM -0.250059401956516 0.419148417832974 no 1970 0.401270705644978 2799 3449522 SGTC_800 3448-7362 155 µM -0.250486745749418 0.418991821388924 no 1971 0.401105476712999 2928 15991913 SGTC_2325 6158266 200 µM -0.251157415708973 0.418746086054842 no 1972 0.400846203406298 2929 3623240 SGTC_491 tetrandrine 80.3 µM -0.251160487543739 0.418744960598921 no 1973 0.400845015970626 2954 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2260 7964312 200 µM -0.251524342914771 0.418611656318962 no 1974 0.400704372035577 3019 231951 SGTC_703 3875-0075 71.8 µM -0.251582885598925 0.418590209135425 no 1975 0.400681744263879 2872 2850814 SGTC_2792 7535235 81.82 µM -0.252640509394881 0.418202789109111 no 1976 0.400273011628954 2951 1281891 SGTC_3250 9135583 49.47 µM -0.25311643998303 0.418028476006347 no 1977 0.400089117589929 2990 7699353 SGTC_534 k292-0788 63.4 µM -0.254502955700151 0.417520746256088 no 1978 0.399553510467744 2995 4146317 SGTC_56 0957-0365 83.25 µM -0.25479968712421 0.417412103672858 no 1979 0.399438908468539 2967 6752360 SGTC_1061 3448-9325 110 µM -0.254815837163442 0.417406190823119 no 1980 0.399432671336623 2849 723482 SGTC_2718 lomofungin 53.02 µM -0.25642966107344 0.416815432271652 no 1981 0.398809543550635 3018 5351222 A RNA synthesis inhibitor. SGTC_1457 k015-0032 57.3 µM -0.25957015782618 0.415666357261165 no 1982 0.397597679035166 2835 4302660 SGTC_2871 9038510 12.99 µM -0.260612206974709 0.415285241109576 no 1983 0.397195787555247 3053 4945164 SGTC_1653 st012112 65 µM -0.260859172992863 0.415194928114857 no 1984 0.397100555113038 3033 720429 SGTC_891 0929-0073 133 µM -0.260975038786054 0.415152558700858 no 1985 0.397055878276714 3001 5603632 SGTC_1117 retinoic acid 1.10837 µM -0.262110427275863 0.414737425935984 no 1986 0.396618153972712 3024 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3233 9132340 49.47 µM -0.265379065249122 0.413542845003115 no 1987 0.395358730842191 2890 17682950 SGTC_141 0443-0274 32.331 µM -0.266136075898892 0.413266295877968 no 1988 0.395067206000266 3004 1627241 SGTC_2828 7998861 71.43 µM -0.266842909865484 0.413008116006558 no 1989 0.394795057215733 2997 2988188 SGTC_1296 1068-0102 11.9 µM -0.268157253287162 0.412528135870855 no 1990 0.394289138622219 2970 767053 SGTC_1130 3454-2858 15.9 µM -0.268493178645043 0.412405481506699 no 1991 0.394159862417434 2978 715628 YIL048W NEO1 SGTC_1746 st038117 42 µM -0.269367615553556 0.412086243868269 no 1992 0.393823402238175 2982 2898218 SGTC_3230 9131665 49.47 µM -0.269606774378639 0.411998942374484 no 1993 0.393731394042015 2867 15943720 SGTC_3133 9127736 49.47 µM -0.269761340012525 0.411942522726645 no 1994 0.393671933344909 2989 27243420 SGTC_184 1494-0393 24.714 µM -0.270325431574886 0.411736633110641 no 1995 0.393454950927969 2854 3090647 SGTC_1682 st012968 530 nM -0.271919574326512 0.411154913299793 no 1996 0.392841930001084 2896 24207270 SGTC_2204 7233102 200 µM -0.272031086186543 0.41111422871837 no 1997 0.392799058507089 2897 2172480 SGTC_1900 st060200 72.8 µM -0.272035111860318 0.411112759987968 no 1998 0.39279751083371 2860 688945 SGTC_894 0960-0238 55.9 µM -0.274756177892181 0.410120289908069 no 1999 0.391751783852827 2894 6741907 YDL195W SEC31 SGTC_2983 9022671 12.99 µM -0.276142357871725 0.409614921338136 no 2000 0.391219364056023 3089 6405161 SGTC_296 1222-0039 74.9 µM -0.276960436674411 0.409316739470913 no 2001 0.390905242581969 2935 5984176 SGTC_334 1502-1024 68.5 µM -0.279092279903929 0.408539949966119 no 2002 0.390087003790939 2979 3296216 SGTC_2098 5376439 882.5 nM -0.279368781737501 0.408439225974117 no 2003 0.389980913124583 2998 2844116 SGTC_578 3460-0051 92 µM -0.280497463223178 0.408028133078639 no 2004 0.389547935719258 2986 2876744 SGTC_1680 diphenhydramine 100 µM -0.281434905634652 0.407686770973252 no 2005 0.389188424364017 2951 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2079 5212404 121 µM -0.284109665737247 0.406713164674429 no 2006 0.388163169935418 3037 758462 SGTC_2320 7373003 200 µM -0.285132833561222 0.406340886091554 no 2007 0.387771188060159 2971 5415828 SGTC_2736 butenafine 14.65 µM -0.287484081006032 0.40548570836803 no 2008 0.386870844627076 2939 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1256 0570-0116 285 µM -0.288214348319789 0.405220192722598 no 2009 0.386591333106136 2930 410638 SGTC_1668 st014914 51.6 µM -0.288825925008875 0.404997864989957 no 2010 0.386357295953064 2979 2839556 SGTC_708 3448-5400 146 µM -0.289656131045214 0.404696107552446 no 2011 0.386039660242813 2993 3462195 SGTC_1322 1348-1070 12 µM -0.291545346740196 0.404009640230749 no 2012 0.385317133826532 3014 6758089 SGTC_2463 5473429 200 µM -0.293741229835911 0.403212113397315 no 2013 0.384477823258823 2985 5399405 SGTC_1209 2323-2347 50.3 µM -0.295327255146422 0.402636332027486 no 2014 0.383871948969098 3010 5412760 SGTC_2597 laccaic acid a 100 µM -0.2954874900163 0.40257817301741 no 2015 0.383810753730638 3063 5491415 A textile dye. SGTC_2347 9049783 174.81 µM -0.296589547221954 0.402178227695592 no 2016 0.383389946048414 3094 6467988 YPL169C MEX67 SGTC_357 1325-0123 420 µM -0.296954241757356 0.402045899677138 no 2017 0.383250721957902 3064 1098503 SGTC_1345 1488-0192 31.4 µM -0.297682515899142 0.401781681797844 no 2018 0.382972744539074 3088 658348 SGTC_1515 3460-0031 42.1 µM -0.299109477443044 0.401264110354754 no 2019 0.382428257590626 2951 2876596 SGTC_1760 st045453 10.4495 µM -0.300117778738085 0.400898495026161 no 2020 0.382043659229098 3065 3323419 YIL048W NEO1 SGTC_772 k072-0172 35.3 µM -0.300500521065154 0.400759733360993 no 2021 0.381897699514536 2944 5861980 SGTC_1087 pterostilbene 9.05 µM -0.300795175640088 0.40065291607936 no 2022 0.381785343712818 3061 5281727 Similar to reservatol, lowers cholesterol. SGTC_100 0086-0128 49.5915 µM -0.301320464412128 0.40046250841995 no 2023 0.381585068656321 2979 93297 SGTC_2898 9056270 58.44 µM -0.303601983630165 0.399635774074687 no 2024 0.380715570079092 2936 19154699 SGTC_2021 4019055 173 µM -0.304510682524044 0.399306621767418 no 2025 0.380369427732021 3096 44827708 YER133W GLC7 SGTC_524 r073-0010 27.8 µM -0.307518955710802 0.398217465674153 no 2026 0.379224198508363 2921 2772106 SGTC_2083 5306046 65.942 µM -0.308151860469836 0.397988420862928 no 2027 0.37898339047269 2953 539837 SGTC_2532 xanthone 78.9 µM -0.308568163900367 0.397837782061727 no 2028 0.378825020656574 3049 7020 An insecticide. SGTC_2749 bexarotene 57.39 µM -0.309200854074874 0.397608873194932 no 2029 0.378584372128727 3046 82146 An retinoic acid receptor inhibitor. SGTC_805 3852-0218 479 µM -0.309275964239957 0.397581700491226 no 2030 0.378555806529395 2933 6615355 SGTC_1306 1185-0270 9.02 µM -0.30978814413085 0.397396421749714 no 2031 0.378361034007474 3064 1548076 SGTC_1048 3161-0300 24.5 µM -0.311148657883826 0.396904374614507 no 2032 0.377843806024576 2954 2165101 SGTC_256 clotrimazole 625 nM -0.314135117169604 0.395824859977814 no 2033 0.37670920943857 3022 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2415 st077333 57.7 µM -0.315342613914128 0.395388612697486 no 2034 0.376250766503092 3209 2766255 SGTC_2915 7971052 15.16 µM -0.316090186574387 0.395118593529623 no 2035 0.37596702758069 3020 5741558 SGTC_562 3772-2733 112 µM -0.316490498538344 0.394974023725399 no 2036 0.375815117947826 3083 2876874 YIL048W NEO1 SGTC_2678 equilin 100 µM -0.316592837803468 0.394937066951146 no 2037 0.375776285523538 3067 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_870 0573-2213 57.6 µM -0.317165823487153 0.394730167726139 no 2038 0.375558890533188 2947 3916321 SGTC_1451 4152-0210 104 µM -0.323244305278937 0.392537129425108 no 2039 0.373255114793216 3136 659563 SGTC_848 0368-0089 85.6 µM -0.324323498538886 0.392148124578361 no 2040 0.3728465655411 3097 762535 SGTC_49 0717-0965 32.132 µM -0.326328435275944 0.391425713576268 no 2041 0.372087938244619 3252 5889349 YGL099W LSG1 SGTC_1565 sinapyl alcohol 95.1 µM -0.327889915991456 0.390863346071594 no 2042 0.371497449251015 3077 5280507 A phenol propionate derived from cinnamic acid. SGTC_3257 9139206 32.98 µM -0.328328037005528 0.390705597664395 no 2043 0.371331823808342 3096 4910041 SGTC_2601 securinine 100 µM -0.328969012746474 0.39047484246473 no 2044 0.371089554939997 2971 442872 A GABA receptor antagonist. SGTC_1302 1159-0335 255 µM -0.32950801926542 0.390280826664129 no 2045 0.370885866795417 2999 649284 SGTC_701 4424-0219 185 µM -0.329893694346532 0.390142019396091 no 2046 0.370740144111543 3158 2911779 SGTC_2665 lovastatin 100 µM -0.331595932552408 0.389529539028578 no 2047 0.370097195661996 3013 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_880 0833-0487 87.2 µM -0.332467586313953 0.389216016381152 no 2048 0.369768105692597 2981 76075 SGTC_1640 st009078 66.4 µM -0.332651805110975 0.389149764472898 no 2049 0.369698566698918 3109 690618 SGTC_2398 5228213 48.84 µM -0.332937864612534 0.389046893260206 no 2050 0.369590593277453 3202 80771 YMR134W ERG29 SGTC_1195 1502-0147 41.1 µM -0.333317397360222 0.388910419696443 no 2051 0.369447354166706 3001 817940 SGTC_263 alizarin 107.927 µM -0.334980088491867 0.388312705820772 no 2052 0.368820053219174 3044 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_3057 9095946 49.47 µM -0.335763444995229 0.388031191815728 no 2053 0.36852462903679 2957 24540043 SGTC_133 0724-0033 378.92 µM -0.336702447601997 0.387693820967634 no 2054 0.368170609042552 2917 280309 SGTC_690 glyoxal 20.3 µM -0.336737260464019 0.387681314808558 no 2055 0.368157486149666 3035 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_3110 9122132 49.47 µM -0.336838403201001 0.387644980991989 no 2056 0.368119360731575 3153 918317 SGTC_987 1497-1013 404 µM -0.337068386961046 0.38756236688095 no 2057 0.368032673953725 3014 1676435 SGTC_2107 5363541 170.161 µM -0.339173809932476 0.386806299903526 no 2058 0.367239398889312 3107 244052 SGTC_2804 7954240 19.48 µM -0.339194132997214 0.386799003886222 no 2059 0.367231744379297 3147 828705 SGTC_576 1073-0113 22.7 µM -0.339472385187981 0.386699114866875 no 2060 0.367126948358981 3076 5439563 SGTC_469 w7 172 µM -0.339913240263597 0.386540868835956 no 2061 0.366960932710671 3027 45115570 A P450 inhibitor. SGTC_4 0960-0234 25.671 µM -0.341747876055465 0.38588252463197 no 2062 0.36627031953014 3089 6821112 SGTC_2027 5150920 200 µM -0.342877286842311 0.385477407962683 no 2063 0.365845389799191 3063 786715 SGTC_2284 7945075 39.21 µM -0.343187367005155 0.38536620486382 no 2064 0.365728753944478 3141 1245402 SGTC_2505 galangin 7.89 µM -0.343443343325359 0.385274411960997 no 2065 0.365632478462222 2951 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3086 9117350 49.47 µM -0.343876789358998 0.385118993219931 no 2066 0.365469473989916 3061 2679265 SGTC_2739 tacrine 100.86 µM -0.344469262157892 0.384906582840053 no 2067 0.365246704205577 3107 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2369 9071472 200 µM -0.344847717096851 0.384770919143385 no 2068 0.365104428930421 3153 17296037 SGTC_2778 tioconazole 65.09 nM -0.346079524682938 0.384329454245099 no 2069 0.364641475342861 2992 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_605 1315-0399 119 µM -0.346577578481372 0.384151000356788 no 2070 0.364454346416505 3153 24020461 SGTC_2478 5763493 32.33 µM -0.346892885347477 0.384038037830657 no 2071 0.364335895917266 3007 1365576 YLR208W SEC13 SGTC_597 k018-0003 82.8 µM -0.346922241848252 0.384027521007737 no 2072 0.364324868297086 3137 6786234 SGTC_1612 st002233 45.4 µM -0.34883336610344 0.383343054159741 no 2073 0.363607206220429 3092 1035021 SGTC_1630 st005209 31.3 µM -0.349202033533069 0.383211058175684 no 2074 0.363468819823902 3104 3367314 SGTC_959 1222-0044 107 µM -0.349875974453022 0.382969798535113 no 2075 0.363215889223664 3163 6083612 SGTC_982 1491-0518 27.5 µM -0.350939251358841 0.38258925542363 no 2076 0.362816961795137 3017 3091256 SGTC_567 1080-0542 68.4 µM -0.352163775703046 0.382151142852994 no 2077 0.362357720882804 3087 5950415 SGTC_2014 4013930 200 µM -0.353086533824764 0.381821096389593 no 2078 0.362011784003258 3106 64556 SGTC_945 3381-0768 11.3 µM -0.353502649433028 0.381672290794488 no 2079 0.361855821431728 3168 1126236 YIL048W NEO1 SGTC_1959 st077091 55.8 µM -0.354318081903499 0.381380737666234 no 2080 0.361550259102881 2980 821356 YKL052C ASK1 SGTC_1525 8-methoxypsoralen 92.5 µM -0.355532337655229 0.38094671236709 no 2081 0.361095411657022 3258 4114 Related to psoralen; DNA damaging agent. SGTC_3119 9125183 49.47 µM -0.355638455067499 0.380908788716256 no 2082 0.361055670509066 3067 22695334 SGTC_2765 myclobutanil 7.74 µM -0.356518901815713 0.380594183705649 no 2083 0.360725999612718 3121 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1666 st014829 29 µM -0.357427374629976 0.380269647058416 no 2084 0.360385943211527 2998 3858230 SGTC_2 0422-0095 29 µM -0.359033157845514 0.379696214228622 no 2085 0.359785142182856 3086 6790840 SGTC_746 1095-0025 46.6 µM -0.361768754486014 0.378719929283232 no 2086 0.358762421581149 3207 6749286 SGTC_281 1672-3440 14.9 µM -0.36604607814895 0.377194981889872 no 2087 0.357165346306404 3149 6833000 SGTC_2873 9040596 71.43 µM -0.366173643347123 0.377149531728904 no 2088 0.357117754013076 3162 6463863 SGTC_188 3229-0966 278.469 µM -0.368123536793867 0.376455017028857 no 2089 0.356390560739179 3171 5722370 SGTC_54 0159-0055 9 µM -0.370054033643447 0.375767804800895 no 2090 0.355671115257633 3285 3319099 SGTC_2446 5162541 200 µM -0.370314142754373 0.37567524203626 no 2091 0.355574218647496 3013 1549321 SGTC_2868 9035608 32.47 µM -0.37042638849206 0.37563530033253 no 2092 0.355532407417911 3012 6462614 SGTC_1039 k821-0043 94 µM -0.371041630240896 0.375416395403395 no 2093 0.35530326244369 3188 15992768 SGTC_1176 0848-0131 83.3 µM -0.372319631521928 0.374961806828987 no 2094 0.354827441887783 3135 6769040 SGTC_757 1066-0008 322 µM -0.373823415731021 0.374427129059283 no 2095 0.354267848615118 3188 6842497 SGTC_2857 9024691 58.44 µM -0.375330319489043 0.373891584244325 no 2096 0.353707409952116 3136 16478292 SGTC_2288 7946289 167.31 µM -0.377015658094494 0.373292913030984 no 2097 0.353080984308556 3254 1246052 SGTC_3255 9139072 49.47 µM -0.37786844182741 0.372990100944347 no 2098 0.352764163554736 3142 17646060 SGTC_1229 0139-0193 12.2 µM -0.378161221277517 0.372886156962331 no 2099 0.352655415535828 3216 3090752 SGTC_568 1193-0097 7.48 µM -0.37864305590826 0.372715113841278 no 2100 0.352476472354143 3156 3646150 SGTC_2610 ononetin 44.17 µM -0.378811026817587 0.372655492914764 no 2101 0.352414099185981 3128 259632 SGTC_313 3474-0040 5.03 µM -0.37884348079258 0.372643973795173 no 2102 0.35240204840639 3035 1043375 YIL048W NEO1 SGTC_1698 5-fluorocytosine 1.055 µM -0.379563895696458 0.372388301166923 no 2103 0.352134582787351 3199 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3249 9135183 49.47 µM -0.37979445352819 0.372306488903775 no 2104 0.35204899992517 3220 4902779 SGTC_2750 bromebric acid 70.15 µM -0.381961721227798 0.371537727238107 no 2105 0.351244878913951 3236 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3152 9099253 49.47 µM -0.382040195864742 0.371509900721251 no 2106 0.351215774944366 3126 25236131 SGTC_419 nsc-638432 893 µM -0.382410612056792 0.371378562988852 no 2107 0.351078410091013 3146 368090 SGTC_2158 5657123 3.6195 µM -0.383322673270434 0.371055239116983 no 2108 0.350740264984615 3103 2858827 SGTC_1371 2421-0008 32.7 µM -0.38333935908312 0.371049324876805 no 2109 0.35073407984888 3086 2827552 SGTC_1561 5-methoxyflavone 52.9 µM -0.38402030305973 0.370807992165531 no 2110 0.35048169972468 3112 94525 SGTC_2273 7815444 169.05 µM -0.384044946784694 0.370799259158477 no 2111 0.350472567190329 3230 2824616 SGTC_2634 4'-methoxyflavone 100 µM -0.384516588038308 0.370632136282352 no 2112 0.350297801835356 3137 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_610 4215-0184 155 µM -0.384908640385968 0.370493233770294 no 2113 0.350152552047614 3141 5605015 SGTC_1182 1222-0449 220 µM -0.385705473268288 0.370210971244586 no 2114 0.349857404422987 3153 658318 SGTC_2580 diallyl disulphide 81.36 µM -0.386730083837718 0.369848125624482 no 2115 0.349478021050602 3064 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_260 nsc-65238 3.989 µM -0.386968555683068 0.369763692131275 no 2116 0.349389743439444 3192 3246252 SGTC_621 3584-0052 32.1 µM -0.388507593011472 0.369218930772685 no 2117 0.348820218049758 3210 2273927 SGTC_1638 st008370 60.6 µM -0.388839565036986 0.369101459539865 no 2118 0.348697415400131 3139 24207134 SGTC_2994 9053520 71.4286 µM -0.389732907097683 0.368785403299443 no 2119 0.348367030246531 3196 4647384 SGTC_1827 berberine 7.24 µM -0.39042975788065 0.36853892545776 no 2120 0.348109393397931 3085 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_194 1486-1323 56.904 µM -0.394081629040272 0.367248136027757 no 2121 0.346760386872025 3141 5178754 SGTC_1590 st077108 57.8 µM -0.394196702478706 0.367207486483845 no 2122 0.346717910025282 3195 5489485 SGTC_2177 5811945 192 µM -0.394659306358276 0.36704408728187 no 2123 0.346547169352811 3236 5343475 SGTC_986 1493-0483 84 µM -0.395397507412114 0.366783392567195 no 2124 0.34627477415507 3213 40079 SGTC_1169 aniline yellow 25.8 µM -0.396774805587056 0.366297165870642 no 2125 0.345766765597374 3111 6051 A DNA damaging agent. SGTC_3108 9121785 49.47 µM -0.397865570259222 0.365912246123554 no 2126 0.345364640180377 3152 17140271 SGTC_352 k048-0007 5.11 µM -0.398522096519427 0.365680629713874 no 2127 0.34512268682034 3198 6811911 SGTC_651 3253-0966 34.4 µM -0.399665758169651 0.365277273401466 no 2128 0.344701357901959 3117 781462 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.400046067758519 0.365143175569138 no 2129 0.344561293166099 3283 5393153 SGTC_1645 Cervolide 78 µM -0.400178262940854 0.365096567175581 no 2130 0.344512611812283 3164 23173 A fragrance. SGTC_2487 5918373 44.05 µM -0.402421840016841 0.36430584790303 no 2131 0.34368679976229 3272 2876279 SGTC_2011 4012611 177 µM -0.403603641715754 0.363889569279343 no 2132 0.343252103647673 3081 2049887 SGTC_2621 lithochol-11-enic acid 100 µM -0.40495960008908 0.36341214343371 no 2133 0.342753603762977 3239 6708711 SGTC_1225 1216-0074 20.6 µM -0.405170436948622 0.363337927912665 no 2134 0.342676116987133 3134 4241466 SGTC_2770 toltrazuril 17.5 µM -0.408295760911705 0.362238402827195 no 2135 0.341528275551304 3223 68591 Kills coccidiodes. SGTC_988 1497-1057 103 µM -0.408320565737538 0.362229680733528 no 2136 0.341519171296065 3250 3533044 SGTC_3045 9092950 49.47 µM -0.408926216313881 0.362016738691276 no 2137 0.341296904570035 3267 44120432 SGTC_127 0180-0333 59.125 µM -0.410054646206005 0.36162010544658 no 2138 0.34088293077058 3189 771601 SGTC_1300 1094-0077 113 µM -0.410309216496234 0.361530646747855 no 2139 0.340789566022587 3131 5532636 SGTC_2218 6965428 192.983 µM -0.411776566659081 0.361015152028602 no 2140 0.340251599299264 3211 675684 SGTC_3214 9129694 49.47 µM -0.412732891579444 0.3606793213204 no 2141 0.339901161865636 3271 17158655 SGTC_34 0469-0683 81.75 µM -0.412764695648243 0.360668154593358 no 2142 0.339889509899711 3196 3690923 SGTC_778 3456-2434 196 µM -0.413269771276521 0.360490833412857 no 2143 0.339704487292743 3240 5539063 SGTC_758 0868-0029 16 µM -0.413960677041225 0.360248319861536 no 2144 0.339451452724516 3234 762687 SGTC_1026 k007-1105 30.6 µM -0.415668597686934 0.35964906725392 no 2145 0.338826261421709 3156 7066794 SGTC_2275 7947463 200 µM -0.418313861467834 0.358721613325594 no 2146 0.337858828152038 3260 1225414 SGTC_509 pifithrin 175 µM -0.418959694322277 0.358495304577082 no 2147 0.337622794637048 3253 4817 A p53 inhibitor. SGTC_1484 3473-2379 286 µM -0.419891013747404 0.358169044893708 no 2148 0.337282536369191 3265 671917 SGTC_316 k060-0003 58.6 µM -0.421727206025607 0.357526093784165 no 2149 0.336612072047309 3244 6152314 SGTC_1365 1672-3266 55.4 µM -0.422350257508443 0.357308021205267 no 2150 0.336384689856811 3246 6415873 SGTC_1141 3253-0389 52.6 µM -0.422521651005851 0.357248040395463 no 2151 0.336322150412579 3231 5402031 SGTC_1699 st031318 29.054 µM -0.423068456319957 0.35705670417766 no 2152 0.336122657950566 3246 5340658 SGTC_3034 9090421 49.47 µM -0.423101046484662 0.35704530147489 no 2153 0.336110769449214 3207 17173761 SGTC_1856 st057054 55.7 µM -0.424854159910018 0.356432107562654 no 2154 0.335471496544492 3344 1266018 SGTC_768 0384-0033 77.3 µM -0.425128530976153 0.356336173164751 no 2155 0.335371490154031 3148 3965305 YMR134W ERG29 SGTC_615 k087-0205 167 µM -0.425628145448158 0.356161505307854 no 2156 0.335189414034653 3166 9642773 SGTC_539 4859-0462 2.54 µM -0.42686268893677 0.355730031869961 no 2157 0.33473967145545 3284 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2565 isoliquiritigenin 100 µM -0.426915831272751 0.355711462746655 no 2158 0.334720317087171 3245 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1657 st012939 43.4 µM -0.427214178004187 0.35560722006965 no 2159 0.334611667756843 3278 24207257 SGTC_2212 7123476 200 µM -0.427299702682856 0.355577339643747 no 2160 0.33458052467298 3173 1085715 SGTC_1320 1313-0481 95.3 µM -0.429091473244858 0.354951539076991 no 2161 0.333928328642151 3323 6813365 YLR208W SEC13 SGTC_1420 4'-methoxyflavone 42 µM -0.430535534893044 0.354447465174125 no 2162 0.333403061706093 3237 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_36 0335-0881 14.2 µM -0.43465338923928 0.353011461188365 no 2163 0.331907017922646 3208 23828853 SGTC_1479 0549-0158 134 µM -0.435394052687791 0.352753393670345 no 2164 0.331638213256966 3217 5440202 SGTC_115 0527-0192 112.043 µM -0.435685991157836 0.35265169288285 no 2165 0.331532285537508 3271 4233931 SGTC_3063 1327-0034 4 µM -0.435735203587641 0.352634550092008 no 2166 0.331514430497276 3241 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_93 0109-0045 59.227 µM -0.437081429751345 0.352165718201549 no 2167 0.331026147173519 3263 88733 SGTC_2738 aclarubicin 5.55 µM -0.437979592762596 0.351853052036517 no 2168 0.330700538411446 3203 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2687 chenodiol 100 µM -0.438158645813099 0.351790732522914 no 2169 0.33063564206529 3276 5702181 A cholesterol synthesis inhibitor. SGTC_2594 a-mangostin 100 µM -0.438412216196452 0.351702484023105 no 2170 0.330543746218468 3298 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2386 9075165 157.42 µM -0.439935517224073 0.351172507511268 no 2171 0.329991905454327 3235 16452277 SGTC_1723 st034307 2.5525 µM -0.440147229797023 0.351098872791274 no 2172 0.329915238342485 3213 867466 SGTC_1356 1502-0781 85.8 µM -0.44103935752052 0.350788647628124 no 2173 0.329592252166025 3170 567702 SGTC_2466 5983409 37.09 µM -0.441320583344889 0.350690875817454 no 2174 0.32949046341747 3205 2879657 SGTC_514 4466-0038 2.65 nM -0.442035234658125 0.350442462510776 no 2175 0.329231854613121 3182 5722064 SGTC_2113 5491891 107.031 µM -0.44355587522588 0.349914099689267 no 2176 0.328681856752291 3229 789979 SGTC_236 1509-0011 5.31 µM -0.44372188727133 0.349856434598623 no 2177 0.328621834576763 3345 3107280 SGTC_858 0438-0351 2.77 µM -0.445378439531698 0.349281213001519 no 2178 0.328023145303491 3224 2799119 SGTC_2858 9025781 8.96 µM -0.447472202012717 0.348554669594824 no 2179 0.327267077171603 3256 4894980 YPL153C RAD53 SGTC_2958 9077254 16.72 µM -0.44857477392079 0.348172295998913 no 2180 0.326869217351932 3378 16457351 SGTC_1809 st050081 57.6 µM -0.449022143748943 0.348017191450296 no 2181 0.326707841352818 3349 5036894 SGTC_1401 3807-4679 7.6 µM -0.449081775036529 0.347996519012103 no 2182 0.326686333501816 3258 3291456 SGTC_1123 mangostin 811.285 nM -0.449172588569361 0.347965037461596 no 2183 0.326653579925117 3238 5281650 An antioxidant. SGTC_1478 0453-0656 35.7 µM -0.449456906161324 0.347866482291469 no 2184 0.326551044178227 3282 5258496 SGTC_87 0100-0052 35.5 µM -0.450486065388729 0.34750982297383 no 2185 0.326179999780303 3320 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_788 1182-0090 188 µM -0.452954286529015 0.346655001330441 no 2186 0.32529082956087 3370 5715185 SGTC_1399 3562-5772 25 µM -0.453452712033985 0.346482475636337 no 2187 0.325111393508087 3188 23847490 SGTC_3073 9114972 49.47 µM -0.453913018286506 0.346323172873527 no 2188 0.324945716621858 3270 41905075 SGTC_1454 4239-0054 42.6 µM -0.456854569030529 0.345305804084011 no 2189 0.323887790093097 3373 1340767 SGTC_1203 3992-3522 103 µM -0.457835376882804 0.344966828424951 no 2190 0.323535358763333 3494 5322312 SGTC_2875 9039966 71.43 µM -0.459124299804074 0.344521554700261 no 2191 0.323072453816366 3245 6463691 SGTC_2764 methyldopa 94.69 µM -0.459837447106378 0.344275281998575 no 2192 0.322816451086562 3377 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_3148 9097893 49.47 µM -0.460347356510989 0.344099234350554 no 2193 0.322633457332569 3167 17174100 SGTC_2255 7941087 197.44 µM -0.461075046474079 0.343848055872306 no 2194 0.322372381966002 3338 935561 SGTC_2346 9031566 143.75 µM -0.46170036241428 0.34363226911969 no 2195 0.3221481055764 3244 4771086 SGTC_2767 sibutramine 71.45 µM -0.463114965587819 0.343144299751765 no 2196 0.321640981700253 3405 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_358 0075-0058 9.45 µM -0.463570133901656 0.342987344352961 no 2197 0.321477878101859 3429 1069125 SGTC_1493 4348-0038 111 µM -0.464824746964872 0.342554857244532 no 2198 0.321028482186167 3316 800424 SGTC_2080 5212524 12.4 µM -0.465008349839035 0.34249158340979 no 2199 0.320962738548572 3315 260183 SGTC_338 4055-0136 114 µM -0.465393473576567 0.342358875144321 no 2200 0.320824853522063 3199 2900563 SGTC_1188 1403-0014 4.57 µM -0.466591142713594 0.341946299508039 no 2201 0.32039621259634 3243 9614867 SGTC_2350 9023895 38.85 µM -0.467666161228999 0.341576135469683 no 2202 0.32001167175431 3344 2997209 SGTC_414 piperonyl butoxide 100 µM -0.467931253862345 0.341484878802156 no 2203 0.319916876156287 3208 5794 A potent inhibitor of cytochrome P450. SGTC_2900 5328528 85.29 µM -0.467947884965026 0.341479153946225 no 2204 0.319910929361732 3274 795359 SGTC_2809 7964133 12.99 µM -0.468851844309301 0.341168042643436 no 2205 0.319587769667685 3239 1253665 SGTC_228 caffeine 993.056 µM -0.469163377242958 0.341060848864043 no 2206 0.31947643035019 3319 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3176 9106582 49.47 µM -0.470002680610315 0.340772121097397 no 2207 0.319176551201268 3255 17018027 SGTC_2309 7664088 163.95 µM -0.472158886374982 0.340030795149649 no 2208 0.318406691625248 3389 704922 SGTC_2278 7948257 134.34 µM -0.472191898000338 0.340019450206434 no 2209 0.318394911115504 3323 1247028 SGTC_3307 9126885 69.2785 µM -0.472959887015381 0.339755560097045 no 2210 0.318120898844428 3208 24824909 SGTC_3277 9138724 49.47 µM -0.47372390948092 0.339493110849162 no 2211 0.317848400547169 3232 15943418 SGTC_1284 0929-0043 16 µM -0.473861730860832 0.339445776128321 no 2212 0.31779925529976 3268 1239883 SGTC_2340 7987427 183.45 µM -0.474097386028981 0.339364846284083 no 2213 0.31771523127738 3325 2239331 SGTC_2172 5754775 163.918 µM -0.474497958817439 0.339227296629754 no 2214 0.317572426598514 3209 2263357 SGTC_965 1291-5240 308 µM -0.475774761644511 0.338789008023997 no 2215 0.317117426072658 3359 2834598 SGTC_370 0180-0345 38.7 µM -0.475974547556361 0.338720447161979 no 2216 0.317046255496662 3161 3989527 SGTC_796 1234-0020 70.7 µM -0.476354769394569 0.338589980567969 no 2217 0.31691082616885 3291 46495034 SGTC_2584 androsterone 48.74 µM -0.476512753162799 0.338535776845838 no 2218 0.316854561927051 3329 2754130 A steroid. SGTC_175 3793-3120 23.7 µM -0.476641841168302 0.338491489649826 no 2219 0.316808591748627 3218 5322297 SGTC_1660 st012960 28.1 µM -0.477844735896392 0.338078910934076 no 2220 0.316380358917197 3304 24207266 SGTC_347 4534-1311 26.2 µM -0.478430651883868 0.337878019029486 no 2221 0.316171860793567 3284 2862016 SGTC_2847 9005661 71.43 µM -0.478742554297026 0.337771096467129 no 2222 0.316060894193484 3299 2991449 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.480465232809346 0.337180784958569 no 2223 0.315448309592247 3250 4330530 SGTC_2920 7982904 15.77 µM -0.481206946941008 0.336926744533926 no 2224 0.315184711997451 3295 6456808 SGTC_170 4197-0004 226 µM -0.48149592774659 0.336827787434494 no 2225 0.315082036641128 3357 218692 SGTC_1220 1838-0075 193 µM -0.482430349936645 0.336507886046592 no 2226 0.314750132709334 3272 5529645 SGTC_637 1181-0519 7.26 µM -0.483563549952501 0.336120091390393 no 2227 0.314347824219936 3330 6252091 YGR060W ERG25 SGTC_2699 st077704 54.6 µM -0.483729417573124 0.336063344116103 no 2228 0.314288956404777 3315 645852 SGTC_628 1636-0253 16 µM -0.484158394298193 0.335916598262765 no 2229 0.314136730859366 3293 4456143 SGTC_2097 5376186 200 µM -0.484724951385688 0.335722826770188 no 2230 0.313935732361036 3326 742755 SGTC_182 3448-4371 550.524 µM -0.485295672639243 0.335527675218778 no 2231 0.313733312335464 3372 3491403 SGTC_1474 0330-0125 5.35 µM -0.485509985101833 0.335454404997304 no 2232 0.313657315738093 3361 X1474 SGTC_3118 9124250 49.47 µM -0.488298846102425 0.33450150660591 no 2233 0.312669089346752 3265 1504786 SGTC_912 3474-0017 2.18 µM -0.488378900519098 0.334474169300726 no 2234 0.312640742078974 3390 3360550 SGTC_1618 st003135 44.5 µM -0.488523782322503 0.334424696709532 no 2235 0.312589442252442 3306 1270615 SGTC_3116 9124943 49.47 µM -0.488785676095206 0.334335275498219 no 2236 0.312496719979175 3266 41905195 YPL160W CDC60 SGTC_210 3551-0445 56.827 µM -0.493164663965787 0.332841506469214 no 2237 0.310948121725128 3391 2865180 YOR207C RET1 SGTC_2099 5377090 177.372 µM -0.494612297374226 0.332348268375871 no 2238 0.310436909991947 3337 2243829 SGTC_2540 epiandrosterone 100 µM -0.49553950915527 0.332032500903893 no 2239 0.310109670150298 3388 441302 A steroid. SGTC_280 3448-3607 3.04 µM -0.498170750189673 0.331137066116237 no 2240 0.309181848404873 3368 626179 SGTC_914 3820-6779 408 µM -0.498560789932516 0.33100441410322 no 2241 0.309044416867883 3249 2893481 SGTC_3226 9131256 49.47 µM -0.498710201906883 0.330953604901796 no 2242 0.308991778240748 3314 17178073 SGTC_1748 st037455 53.6035 µM -0.499804730053703 0.33058149344186 no 2243 0.308606289859203 3407 580690 SGTC_1136 pergolide 1.05886 µM -0.500549588320611 0.330328356460871 no 2244 0.308344074326706 3229 47811 A dopamine receptor agonist. SGTC_16 erodoxin 22.806 µM -0.500688983344511 0.330280992261883 no 2245 0.308295013375236 3401 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2595 hexamethylquercetagetin 100 µM -0.502154084446921 0.329783338955772 no 2246 0.30777956912354 3274 386331 SGTC_3065 9113888 49.47 µM -0.502246595668072 0.329751925616857 no 2247 0.307747035021828 3451 16648368 SGTC_3183 9108214 49.47 µM -0.502689741619069 0.329601466539544 no 2248 0.307591211591911 3327 4974831 SGTC_2717 st081029 62.2815 µM -0.502806183263214 0.329561936277991 no 2249 0.307550272968776 3373 5292846 SGTC_383 2324-0395 7.37 µM -0.504676706919097 0.328927181697001 no 2250 0.306892961925048 3391 3146421 SGTC_900 1112-0045 141 µM -0.505072224651825 0.328793027454887 no 2251 0.30675405446293 3311 56211 YIL048W NEO1 SGTC_536 3852-0578 10.6 µM -0.506779816579658 0.328214088832871 no 2252 0.306154659809542 3411 2869208 SGTC_2215 7188065 200 µM -0.507495543628122 0.327971552696218 no 2253 0.305903581215272 3401 940217 SGTC_3177 9107506 49.47 µM -0.508252521027466 0.327715117101307 no 2254 0.305638131127374 3362 8897194 SGTC_1610 st001799 48.1 µM -0.508261013652975 0.327712240578398 no 2255 0.30563515358815 3235 621897 SGTC_183 3914-0051 30.55 µM -0.508888618762422 0.327499693812951 no 2256 0.30541514899043 3392 1596232 SGTC_1819 st053448 58.6 µM -0.509696405728787 0.327226208358932 no 2257 0.305132085736889 3262 2857616 SGTC_1903 st060211 78.3 µM -0.509992624635376 0.327125943311738 no 2258 0.305028314432708 3413 688960 SGTC_1761 st044296 37 µM -0.510797011251131 0.326853735113603 no 2259 0.304746601092248 3289 1826700 SGTC_1361 1608-0041 5.61 µM -0.511274138149502 0.326692316651928 no 2260 0.304579555752627 3331 X1361 SGTC_1550 gossypolone 36.6 µM -0.511283736647133 0.326689069683511 no 2261 0.304576195671964 3344 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_644 1498-1197 63.3 µM -0.5113155981033 0.326678291721937 no 2262 0.304565042267321 3402 6741615 SGTC_1114 scopoletin 1.73284 µM -0.511364556384898 0.326661730598885 no 2263 0.304547904311046 3417 5280460 A coumarin with genotoxic properties. SGTC_168 3970-0862 530.542 µM -0.513557469125012 0.325920284467228 no 2264 0.303780710749271 3367 3135186 SGTC_2997 9067075 71.4286 µM -0.514181070340292 0.325709564032579 no 2265 0.303562700576088 3358 27209819 SGTC_1966 st070145 16.1 µM -0.51554502515897 0.325248865620152 no 2266 0.303086107448652 3266 3748532 SGTC_2675 theaflavin digallate 100 µM -0.516624268213724 0.324884522482591 no 2267 0.302709235696699 3384 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.516642217625692 0.324878464330677 no 2268 0.302702969535815 3335 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2490 carminic acid 95.39 µM -0.517492561847002 0.324591515570339 no 2269 0.302406179975744 3387 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_356 1634-0012 32.5 µM -0.517562145291743 0.324568039233652 no 2270 0.302381899541231 3408 735457 SGTC_2710 st078562 53.7235 µM -0.52064833851486 0.323527509407361 no 2271 0.301305884526795 3325 17250908 SGTC_111 0083-0039 52.457 µM -0.52101221643335 0.323404916321671 no 2272 0.301179130577969 3340 759313 SGTC_1631 benzylvanillin 81.9 µM -0.521456970784743 0.323255101418814 no 2273 0.301024236607646 3398 75506 SGTC_3129 9127257 49.47 µM -0.521782036151615 0.323145621714704 no 2274 0.300911049269992 3261 837894 SGTC_2142 5622915 118.518 µM -0.522555482138628 0.322885192199511 no 2275 0.300641813576383 3357 5322196 SGTC_1211 1056-0033 32.3 µM -0.52295063214852 0.322752173456126 no 2276 0.300504304276907 3429 6741922 SGTC_467 ro 31-8220 72.8 µM -0.523766482792713 0.322477606658964 no 2277 0.300220484155844 3315 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1693 xanthone 101.9 µM -0.524913678237002 0.322091692678583 no 2278 0.299821600148706 3351 7020 An insecticide. SGTC_2931 9014674 55.67 µM -0.525197977428635 0.321996084697572 no 2279 0.299722785404301 3286 2996810 SGTC_1971 st069429 63.5 µM -0.525294493971893 0.321963629486001 no 2280 0.299689242206699 3395 1246522 YGL099W LSG1 SGTC_2848 9016370 25.97 µM -0.525513095885143 0.321890126162263 no 2281 0.299613275952386 3459 7894410 SGTC_1844 rapamycin 4 nM -0.526789603753799 0.321461048787612 no 2282 0.299169851609075 3365 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1845 st056753 3.01 µM -0.526906293648402 0.321421837246084 no 2283 0.299129331554411 3260 5375839 SGTC_2846 9008642 19.48 µM -0.527613292081745 0.321184305698273 no 2284 0.298883882733393 3398 2992898 SGTC_373 0844-0104 25.9 µM -0.528204755044118 0.3209856469915 no 2285 0.298678614710752 3415 5375804 SGTC_3127 9126946 49.47 µM -0.530296759429711 0.320283402572126 no 2286 0.297953096571049 3342 27243249 SGTC_2403 6032726 181.2 µM -0.532073061613693 0.319687637843245 no 2287 0.297337697024803 3354 2881040 SGTC_819 1013-0258 27.7 µM -0.533239903173964 0.319296536713583 no 2288 0.296933761279747 3366 5753198 SGTC_2040 5100729 123 µM -0.533505423487102 0.319207567858807 no 2289 0.296841878869277 3336 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1564 D-Arginine 115 µM -0.53398437380445 0.319047110567812 no 2290 0.296676172639249 3349 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_843 0310-0051 143 µM -0.534310899529316 0.31893773779082 no 2291 0.29656322624148 3371 2065037 SGTC_2115 tiliquinol 12.7705 µM -0.534385770803265 0.318912661194507 no 2292 0.29653733078089 3363 71208 A bioactive hydroxyquinoline. SGTC_3068 9116768 49.47 µM -0.536768850897062 0.318114931029232 no 2293 0.29571364521926 3416 41904888 SGTC_3091 9116372 49.47 µM -0.537320840715653 0.317930273917307 no 2294 0.295523006049821 3467 17169793 SGTC_418 lividomycin a 100 µM -0.537999896745109 0.317703171446749 no 2295 0.295288559938538 3450 72394 An antibiotic. SGTC_1603 st002045 67.8 µM -0.538228312487733 0.31762679583911 no 2296 0.295209717968361 3449 5887985 SGTC_3024 9090631 49.47 µM -0.53827969111385 0.317609617383937 no 2297 0.295191985008745 3412 25236383 SGTC_35 0133-0054 64.071 µM -0.538348330922508 0.317586668261266 no 2298 0.295168295242592 3357 99677 SGTC_3281 9140613 49.47 µM -0.539536159204561 0.317189639298612 no 2299 0.294758476898194 3370 16013766 SGTC_1569 carminic acid 40.6 µM -0.539703688217184 0.317133660011295 no 2300 0.29470069802571 3445 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_948 3448-0295 75.3 µM -0.53982502149733 0.317093119493783 no 2301 0.294658854803579 3439 678569 SGTC_76 0433-0009 400.328 µM -0.540183421243978 0.316973381894752 no 2302 0.294535272401404 3407 2841569 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.540467876289355 0.316878362086035 no 2303 0.294437204433394 3403 16623 A steroid. SGTC_683 panaxydol 45 µM -0.540947325108883 0.316718233587762 no 2304 0.29427194505056 3425 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2384 9036245 200 µM -0.54122247589443 0.31662635298142 no 2305 0.294177123729633 3353 6462766 SGTC_657 3534-0529 86.7 µM -0.54124647431102 0.316618339769705 no 2306 0.29416885416436 3436 1049549 SGTC_2156 5649887 115 µM -0.541671711531656 0.316476364850076 no 2307 0.294022340357876 3445 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1665 st014639 11.4 µM -0.54349353988726 0.315868413158304 no 2308 0.293395018785882 3475 981133 YIL048W NEO1 SGTC_3144 9087057 49.47 µM -0.54399303257615 0.315701817244222 no 2309 0.293223133718608 3408 17249618 SGTC_2036 5160441 105 µM -0.544811225244107 0.315429006154274 no 2310 0.292941678753632 3382 134534 YIL048W NEO1 SGTC_1793 st048256 72.231 µM -0.546713177900139 0.314795224359975 no 2311 0.292287899656944 3403 672022 SGTC_1063 disulfiram 1.84 µM -0.547377489384119 0.314573986253746 no 2312 0.29205970858856 3407 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2971 9092186 9.93 µM -0.548459294448578 0.314213851194878 no 2313 0.291688286013219 3311 25236400 SGTC_2795 7780010 54.55 µM -0.549410447010122 0.313897356656347 no 2314 0.291361903134693 3432 953673 SGTC_79 0052-0007 94.094 µM -0.550038793448136 0.313688350411034 no 2315 0.291146382955625 3499 2801472 SGTC_3084 9116877 49.47 µM -0.550309633474657 0.31359827959914 no 2316 0.291053508933818 3393 27241325 SGTC_1215 3852-0577 11.2 µM -0.551075260811901 0.313343721974366 no 2317 0.290791041789272 3487 2884876 SGTC_1588 farnesol 29.9 µM -0.551632198976507 0.313158605674645 no 2318 0.290600185599988 3447 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1641 st009299 47.1 µM -0.554470577852903 0.312215911372308 no 2319 0.289628418016065 3426 4046054 SGTC_1429 4049-0205 9.46 µM -0.55473114334432 0.312129432722271 no 2320 0.289539285461064 3477 22774478 SGTC_835 0312-0010 67.2 µM -0.557990767314448 0.311048477495167 no 2321 0.288425344384041 3400 1626196 SGTC_146 3448-8650 53.125 µM -0.55801528071154 0.311040354528441 no 2322 0.288416974855401 3407 2891488 YIL048W NEO1 SGTC_2617 dihydrotanshinone i 20.83 µM -0.561016774817917 0.310046450702332 no 2323 0.287393050843822 3398 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_380 3970-0968 6 µM -0.561485440433908 0.309891383432195 no 2324 0.287233326480645 3387 2891601 SGTC_2899 9053889 58.44 µM -0.561973661495877 0.30972988181813 no 2325 0.287066982184283 3451 6470052 SGTC_910 3454-3003 490 µM -0.562374333323411 0.309597368580992 no 2326 0.286930501326662 3465 820824 SGTC_336 4111-0029 111 µM -0.56281051750378 0.30945313856224 no 2327 0.286781958853932 3404 3131175 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.563762384523975 0.309138493171 no 2328 0.286457927277736 3368 390807 SGTC_1246 0422-0085 105 µM -0.564725722449536 0.308820198483292 no 2329 0.2861301678052 3500 264295 SGTC_1430 4049-0248 69.1 µM -0.565545998615589 0.308549285695937 no 2330 0.28585122319044 3493 22774488 SGTC_1359 1582-0056 520 nM -0.565565372910978 0.30854288820216 no 2331 0.285844636295516 3479 3661189 SGTC_113 0099-0221 2.5 µM -0.56580023865673 0.308465338926713 no 2332 0.285764792114101 3528 89219 SGTC_590 k048-0076 22.4 µM -0.566173833280535 0.308342000986688 no 2333 0.285637807984305 3469 6832814 SGTC_941 3237-0776 460 µM -0.567854732066269 0.307787339473048 no 2334 0.285066805985954 3501 760008 SGTC_439 amiodarone 34.4 µM -0.56861681369927 0.307536012983021 no 2335 0.284808105961559 3349 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2052 5265182 7.135 µM -0.570444011361551 0.306933790496391 no 2336 0.284188293055877 3459 1239884 SGTC_2121 5257820 149.641 µM -0.571190346954553 0.306687956862493 no 2337 0.283935310463694 3512 791256 SGTC_1325 1431-0015 227 µM -0.572583556825332 0.306229283580147 no 2338 0.283463347888342 3387 1103340 SGTC_497 capsazepine 133 µM -0.572862591363536 0.3061374561456 no 2339 0.283368867604908 3412 2733484 A calcium channel blocker. SGTC_1914 st062367 72.6 µM -0.573411505265496 0.305956849701015 no 2340 0.283183051031535 3413 978205 SGTC_816 0325-0417 81.3 µM -0.573536036730713 0.305915882287703 no 2341 0.283140903176261 3466 68101 SGTC_1982 st072467 71.9 µM -0.574094357699177 0.305732239958098 no 2342 0.282951975641586 3347 3163533 SGTC_2239 6685329 187.64 µM -0.574455447737216 0.305613496620143 no 2343 0.282829820367818 3483 805680 SGTC_1443 4112-3303 14 µM -0.575006955416524 0.305432174485941 no 2344 0.282643296493322 3467 704433 SGTC_1268 0828-0275 2.46 µM -0.576917269826234 0.3048044793132 no 2345 0.281997671837035 3485 745337 SGTC_1712 st032288 53.4 µM -0.577217391515042 0.304705916826148 no 2346 0.281896304985071 3500 2883011 SGTC_2240 6690706 185.951 µM -0.577383865589808 0.304651251450775 no 2347 0.281840085520122 3391 805876 SGTC_114 0364-0001 490.298 µM -0.577415069005606 0.304641005617387 no 2348 0.281829548508623 3478 4003655 SGTC_371 0195-0006 7.36 µM -0.577535366706317 0.304601506562251 no 2349 0.281788927224748 3416 3928593 SGTC_2752 diclazuril 33.15 µM -0.577590244088606 0.304583488647424 no 2350 0.281770397552489 3474 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1330 1469-0054 61.8 µM -0.578257240272736 0.30436453141205 no 2351 0.281545229313077 3488 7102664 SGTC_2196 6573537 42.6665 µM -0.57915335476561 0.304070471059341 no 2352 0.281242850759557 3538 2903087 SGTC_261 5-fluorouridine 15.376 µM -0.580702321028674 0.303562475971323 no 2353 0.280720548578019 3555 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_724 3910-0327 137 µM -0.582390535624656 0.303009245384579 no 2354 0.280151827531669 3488 2885483 SGTC_2884 9058502 51.95 µM -0.582440548206448 0.302992863065139 no 2355 0.280134987950378 3501 6471554 SGTC_1088 bifonazole 369 nM -0.584596279333932 0.302287100342231 no 2356 0.279409605027592 3454 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_106 0092-0003 11.579 µM -0.585162795042147 0.302101751771952 no 2357 0.279219129403262 3443 1072148 SGTC_895 0964-0006 13.7 µM -0.58545362525035 0.302006619843369 no 2358 0.27912137011314 3497 6738897 SGTC_2305 7443522 69.23 µM -0.586631381097587 0.301621508015996 no 2359 0.27872565101817 3471 5415886 SGTC_2335 9018011 154.17 µM -0.586867722174669 0.301544253977362 no 2360 0.278646274708993 3471 6458208 SGTC_3340 9146634 11.102 µM -0.587011664588147 0.301497207133565 no 2361 0.278597936337912 3497 4907387 SGTC_2056 5235370 200 µM -0.587758819571883 0.301253056424397 no 2362 0.278347094307838 3426 5511916 SGTC_3283 9109332 35.8195 µM -0.58933444286506 0.300738476071535 no 2363 0.277818472083372 3400 17027281 SGTC_3198 9112019 49.47 µM -0.589745006450918 0.300604455919532 no 2364 0.277680808386157 3494 45595555 SGTC_913 3487-1245 167 µM -0.59040322553709 0.300389649940443 no 2365 0.277460174311714 3429 4016153 SGTC_3325 9138760 55.175 µM -0.590768796261483 0.300270378019464 no 2366 0.277337672562903 3412 43844959 SGTC_2932 9016711 44.54 µM -0.591079905051193 0.300168891834789 no 2367 0.27723344169451 3516 7117328 SGTC_203 k066-0004 30.888 µM -0.595712179889726 0.298659645149247 no 2368 0.275683760034528 3568 6795412 SGTC_2189 6047310 154.431 µM -0.596406267187629 0.298433801330639 no 2369 0.275451927356295 3480 711535 SGTC_1360 1598-0022 39.8 µM -0.596742537433103 0.298324412851206 no 2370 0.275339643949419 3505 761525 SGTC_209 4077-0173 175.592 µM -0.59725210248635 0.298158686486182 no 2371 0.275169538916854 3462 15993494 SGTC_3038 9091290 49.47 µM -0.597359189363996 0.298123863844425 no 2372 0.275133797330496 3552 25236843 SGTC_1312 1218-2183 165 µM -0.598085745558841 0.297887650359082 no 2373 0.274891360493921 3535 6744073 SGTC_1025 k007-0731 70 µM -0.599264308823428 0.297504664712135 no 2374 0.274498322242574 3436 6256118 SGTC_2207 7258803 200 µM -0.600638171486053 0.297058498630133 no 2375 0.274040504032291 3503 3666799 SGTC_718 1130-0073 349 µM -0.600672145660736 0.297047469291547 no 2376 0.274029187453221 3592 6740020 SGTC_33 0986-0033 35.816 µM -0.601100831974055 0.296908317133281 no 2377 0.273886414643627 3481 2848082 SGTC_780 0109-0199 192 µM -0.601682936256857 0.29671941305831 no 2378 0.273692605288493 3575 610414 SGTC_2978 9011784 42.97 µM -0.601830312048539 0.296671595500932 no 2379 0.27364354785717 3509 2994934 SGTC_1756 st041558 35.5 µM -0.602862763595408 0.296336705221318 no 2380 0.273299994594472 3603 3955792 SGTC_1167 k781-0610 148 µM -0.604272546080032 0.29587970245161 no 2381 0.272831227913645 3522 4525169 SGTC_3095 9117207 49.47 µM -0.605412156175272 0.295510516980255 no 2382 0.272452587961661 3496 17015229 SGTC_488 nitrendipine 139 µM -0.605854373853195 0.295367314227928 no 2383 0.272305729705084 3536 4507 Dihydropyridine L-type calcium channel blocker. SGTC_412 gemfibrozil 100 µM -0.606527809526037 0.295149297821152 no 2384 0.272082160699868 3517 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1483 3453-0561 55.9 µM -0.607171131936567 0.294941099435766 no 2385 0.27186867404367 3534 4546991 SGTC_1080 nisoldipine 24.4 µM -0.607814749534714 0.294732873264877 no 2386 0.271655172859861 3478 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2851 9015922 71.43 µM -0.608843720542529 0.29440011665691 no 2387 0.271314015522678 3541 2996893 SGTC_351 caspofungin 25 nM -0.609054963816604 0.294331824636846 no 2388 0.271244003831707 3554 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_660 4031-1742 102 µM -0.609529919159701 0.294178304884267 no 2389 0.271086623777689 3475 6738706 SGTC_1342 1486-1464 234 µM -0.609855779947825 0.294072998348982 no 2390 0.270978673682528 3557 3253938 SGTC_1416 3966-0321 25.3 µM -0.610449214419425 0.293881266354915 no 2391 0.270782137761165 3514 582530 YLR208W SEC13 SGTC_3298 9116858 71.43 µM -0.610764329109009 0.293779479855677 no 2392 0.270677805793135 3551 2506942 SGTC_1058 3448-5425 97.3 µM -0.611609022074925 0.293506712586209 no 2393 0.270398233732451 3505 7279705 SGTC_286 k060-0067 22.9 µM -0.611713125255339 0.293473103828549 no 2394 0.270363788198217 3486 5985051 SGTC_2845 9003024 42.97 µM -0.612746859404839 0.293139469008969 no 2395 0.270021866564231 3600 2990173 SGTC_1917 st066507 28.5 µM -0.613979546726609 0.292741852692295 no 2396 0.269614421505887 3463 3156428 SGTC_1218 1348-1416 30.7 µM -0.614252378881193 0.292653881661669 no 2397 0.269524282855503 3532 6787668 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.614529787946143 0.292564447461248 no 2398 0.26943264756649 3499 1241132 A phosphatase inhibitor. SGTC_1237 0330-0133 46.1 µM -0.61712841767153 0.291727289852688 no 2399 0.268575012990562 3501 X1237 YHR072W ERG7 SGTC_1436 4092-1007 8.32 µM -0.619309563626854 0.291025489016904 no 2400 0.267856222683896 3522 2881121 SGTC_926 2268-1401 59.4 µM -0.619338566732787 0.291016162355767 no 2401 0.267846671326851 3547 2931578 SGTC_931 2812-0076 566 µM -0.621382144250306 0.290359351647326 no 2402 0.267174108782162 3550 3450959 SGTC_1226 3909-7979 35.4 µM -0.621998024927399 0.290161542327723 no 2403 0.266971583361011 3555 6615510 SGTC_1634 st006576 41 µM -0.623271692959556 0.289752664491995 no 2404 0.266552998111177 3573 3915356 SGTC_640 3381-0960 37.1 µM -0.623729720962131 0.289605692692665 no 2405 0.266402550455798 3588 1745025 SGTC_1183 1254-0324 198 µM -0.62408605134924 0.289491377784121 no 2406 0.266285536958167 3567 5799357 SGTC_673 1082-0474 110 µM -0.62433138292325 0.289412684898443 no 2407 0.266204988911219 3558 3098046 SGTC_2416 tofa 880 nM -0.625023404899686 0.289190765167436 no 2408 0.265977848530327 3445 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1094 duloxetine 25.4 µM -0.62694204863898 0.288575907355894 no 2409 0.265348611504055 3563 60834 A selective serotonin reuptake inhibitor. SGTC_2952 9073731 13.78 µM -0.628396289752286 0.288110284952608 no 2410 0.264872183512417 3530 16457353 SGTC_2543 pimpinellin 60.67 µM -0.629006441698754 0.287915030671802 no 2411 0.264672419491901 3501 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1684 st024538 14.6195 µM -0.630296761490199 0.287502322284523 no 2412 0.264250220721854 3518 6732859 SGTC_978 1416-0512 87.4 µM -0.6310274439492 0.287268737848952 no 2413 0.264011290134025 3582 6814003 SGTC_1508 1080-0625 72.9 µM -0.63161747290365 0.287080183065296 no 2414 0.263818433121641 3506 767111 SGTC_3040 9091894 49.47 µM -0.633075677932342 0.286614437950279 no 2415 0.263342112194453 3500 25236966 SGTC_2057 5236571 38.335 µM -0.633510966496064 0.286475477932867 no 2416 0.263200010860551 3571 54684039 YBR257W POP4 SGTC_3354 9151612 71.43 µM -0.635639375374038 0.285796472762523 no 2417 0.262505749490039 3566 27261949 SGTC_221 trifluoperazine 10.304 µM -0.635957063720707 0.285695189486224 no 2418 0.262402203833999 3593 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1388 3346-4487 254 µM -0.636062782207985 0.285661488811598 no 2419 0.2623677511489 3600 3345614 SGTC_1490 4089-0339 670 nM -0.636219680351323 0.285611476701332 no 2420 0.262316623753893 3541 742542 SGTC_2544 sphondin 68.51 µM -0.636673701430937 0.285466778568001 no 2421 0.262168703560522 3589 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_52 0329-0193 875 nM -0.638773181807901 0.284798120969225 no 2422 0.2614852484915 3651 3739292 SGTC_2460 5552655 174.22 µM -0.639222092176146 0.284655245814437 no 2423 0.261339231102945 3575 5401989 SGTC_1556 plumbagin 1.48 µM -0.639305412355988 0.284628731182447 no 2424 0.261312134098925 3539 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1555 citronellol 128 µM -0.639943184614796 0.284425814654651 no 2425 0.26110476856638 3545 8842 A terpine precursor. SGTC_601 0986-0029 62.9 µM -0.642315019930844 0.283671787817195 no 2426 0.260334331944725 3588 24747981 SGTC_2135 5326629 150.42 µM -0.642769984389837 0.28352726022337 no 2427 0.260186681099604 3547 5020077 SGTC_1615 st002656 86.5 µM -0.643820464362963 0.283193691342171 no 2428 0.259845930945455 3601 1584458 SGTC_1163 k060-0048 49.9 µM -0.644437424129192 0.282997870046269 no 2429 0.25964591157339 3598 6809982 SGTC_850 0388-0143 75.9 µM -0.646355120300935 0.282389614047336 no 2430 0.259024699182796 3552 67273 SGTC_3180 9109287 49.47 µM -0.648823061967512 0.281607757477087 no 2431 0.258226374605834 3588 18891271 SGTC_2711 st079103 59.1 µM -0.649062547369325 0.281531942876951 no 2432 0.258148974314409 3588 54693780 SGTC_809 3998-0021 90 µM -0.649290591257166 0.281459759503303 no 2433 0.258075283035681 3539 715485 SGTC_1575 cyproterone acetate 48 µM -0.64933242263472 0.281446519468945 no 2434 0.258061766612644 3526 9880 An androgen receptor antagonist and liver toxin. SGTC_2780 5215298 71.43 µM -0.651930540932535 0.280624779498612 no 2435 0.257222990875919 3606 2834131 SGTC_2583 asiatic acid 100 µM -0.6522493981824 0.280524010481224 no 2436 0.257120148826523 3625 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2374 9071832 200 µM -0.652868163763761 0.280328510887865 no 2437 0.256920637407702 3576 17381698 SGTC_362 0310-0100 9.03 µM -0.656390866227102 0.279216768428039 no 2438 0.25578633288173 3620 790235 SGTC_928 2764-0428 58.7 µM -0.656606267536064 0.279148858731056 no 2439 0.255717058918604 3595 662578 SGTC_2435 5706476 10.6 µM -0.657659467214076 0.278816931509731 no 2440 0.255378486584465 3613 5725375 SGTC_3117 9124945 49.47 µM -0.658263967797406 0.278626503442653 no 2441 0.255184263526413 3537 17592065 SGTC_454 lyso-paf C-16 6.67 µM -0.659008786767425 0.278391959801612 no 2442 0.254945063122528 3553 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2055 5235184 200 µM -0.65967899789939 0.278180992460003 no 2443 0.254729923536003 3619 2836034 SGTC_2524 avocatin b 10.57 µM -0.660066650391358 0.278059003802004 no 2444 0.254605529443622 3556 6710748 SGTC_845 0330-0138 4.51 µM -0.661203785153092 0.277701314498356 no 2445 0.25424081707869 3583 9039800 SGTC_2451 5856223 45.7 µM -0.662081066072734 0.277425516691718 no 2446 0.253959634737752 3594 2179896 SGTC_1688 st021091 57.6 µM -0.662648770321087 0.277247114364567 no 2447 0.253777763598463 3626 3656366 SGTC_258 haloperidol 50.781 µM -0.662684175745521 0.277235989990166 no 2448 0.253766423294749 3589 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1077 5-fluorocytosine 377 nM -0.663016190470661 0.277131681681972 no 2449 0.25366009242957 3599 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2571 chrysanthemic acid 100 µM -0.66320767188576 0.277071533135387 no 2450 0.25359877933074 3562 2743 An insecticide. SGTC_2000 st075254 36.4 µM -0.66343694038688 0.276999523235266 no 2451 0.25352537690118 3598 17234175 SGTC_2151 5563267 85.4165 µM -0.663658573429189 0.276929920231687 no 2452 0.253454429646832 3623 5310824 SGTC_2887 9044784 58.44 µM -0.664302935500514 0.276727609457463 no 2453 0.253248221304829 3632 6465546 SGTC_3054 9094397 49.47 µM -0.667074679194612 0.275858189898468 no 2454 0.252362216487271 3609 2598354 SGTC_3147 9097027 49.47 µM -0.668153416767997 0.275520182834641 no 2455 0.252017833661482 3640 25236841 SGTC_2988 9073640 71.4286 µM -0.668635601875034 0.275369162897821 no 2456 0.251863978149023 3653 9102229 SGTC_3212 9128307 49.47 µM -0.669022534972864 0.275248005268913 no 2457 0.251740551492392 3560 27243542 SGTC_1020 4335-0961 93.3 µM -0.669811704481669 0.275000979560835 no 2458 0.251488915655613 3571 669075 SGTC_1089 terbinafine 2.25 µM -0.672523016290787 0.274153118321379 no 2459 0.250625396272221 3618 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_833 3852-0053 558 µM -0.673334475391872 0.273899616168664 no 2460 0.250367262256762 3669 3123681 SGTC_21 0849-0113 22.993 µM -0.673784480672783 0.273759083195985 no 2461 0.250224171427969 3607 1560156 SGTC_600 1495-0418 41.6 µM -0.674014896829831 0.273687139920101 no 2462 0.250150921437134 3637 5377768 SGTC_667 1498-1044 59 µM -0.674369570655055 0.273576417717648 no 2463 0.250038191790452 3654 6739982 SGTC_1877 wortmannin 25 µM -0.674490759476595 0.27353859002951 no 2464 0.249999679274407 3632 312145 A covalent inhibitor of PI 3-kinase. SGTC_163 TUB2.036 7.546 µM -0.674969014417731 0.273389333555204 no 2465 0.249847725677398 3658 15992207 YJR013W GPI14 SGTC_3146 9095609 49.47 µM -0.675531673552095 0.27321378739479 no 2466 0.249669017542158 3657 17173999 SGTC_3098 9119039 49.47 µM -0.676177261939081 0.273012436644441 no 2467 0.249464053623842 3662 17161528 SGTC_533 1222-0222 6.71 µM -0.676467780262211 0.27292185170661 no 2468 0.249371847915857 3693 3982874 SGTC_1662 st014054 52 µM -0.676805324573308 0.272816622573187 no 2469 0.249264739693628 3647 2838777 SGTC_2861 9024595 19.48 µM -0.677089093201836 0.272728173534859 no 2470 0.249174714287482 3584 16482810 SGTC_679 0422-0091 41.4 µM -0.677451378179836 0.272615272087648 no 2471 0.249059804758767 3659 627384 YHR062C RPP1 SGTC_452 diindolylmethane 8 µM -0.679485398682026 0.27198182688286 no 2472 0.248415178082328 3607 3071 Inhibits expression of several cancer promoting factors. SGTC_88 0180-0332 8.668 µM -0.682168061687649 0.271147499026094 no 2473 0.247566343756733 3700 3101745 SGTC_3142 9086498 49.47 µM -0.682681594938451 0.270987932076186 no 2474 0.247404031105962 3602 25236367 SGTC_1507 4075-3230 155 µM -0.684296854454088 0.27048633828258 no 2475 0.246893866432738 3589 659771 SGTC_2127 5253358 187.912 µM -0.684971197208015 0.270277068947899 no 2476 0.246681048270923 3603 20612 SGTC_1145 3546-0597 10.2 µM -0.685740861936657 0.270038317232989 no 2477 0.246438267219858 3619 875334 SGTC_3193 9111931 49.47 µM -0.686232244823506 0.269885944377829 no 2478 0.246283333669142 3695 17087244 SGTC_2202 7226349 200 µM -0.686903428039059 0.269677886829935 no 2479 0.246071793287909 3615 844334 SGTC_776 4476-4378 112 µM -0.687433456016274 0.269513642254564 no 2480 0.245904810453509 3659 2892008 SGTC_1245 0418-0076 17.2 µM -0.687524818362448 0.269485336042236 no 2481 0.245876033319589 3652 6790114 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.688718787884023 0.269115553120358 no 2482 0.245500125333774 3678 66535 A nucleotide analog. SGTC_31 0508-1974 57.237 µM -0.689045485579139 0.269014416336941 no 2483 0.245397322036327 3623 6810525 SGTC_2975 9084847 53.72 µM -0.689072597451132 0.26900602409095 no 2484 0.245388791672627 3673 27211724 SGTC_670 4204-0025 119 µM -0.689589603795405 0.268846014389833 no 2485 0.245226153501627 3669 719039 SGTC_1788 fluconazole 20 µM -0.690214539818016 0.268652665065419 no 2486 0.245029640557099 3640 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_483 fpl-64176 144 µM -0.690329963310934 0.268616961768853 no 2487 0.244993354575408 3665 3423 SGTC_1734 st037168 69.4 µM -0.690782753396948 0.268476925799699 no 2488 0.24485103770517 3670 708907 SGTC_3219 9131112 49.47 µM -0.693346755864238 0.267684640835235 no 2489 0.244045983756551 3609 17612988 YMR079W SEC14 SGTC_2640 pentamidine 10.38 µM -0.695558264405664 0.267002225381974 no 2490 0.243352755460513 3684 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1849 st056239 19.2 µM -0.695608251655596 0.266986810744322 no 2491 0.243337098565375 3638 5393181 SGTC_889 0919-1524 82.7 µM -0.696964353367841 0.266568799342166 no 2492 0.242912551193306 3679 3905452 SGTC_2075 5212009 200 µM -0.698251524510874 0.266172341815877 no 2493 0.242509954544156 3586 780898 SGTC_2020 4017018 200 µM -0.699952529465428 0.265648878966235 no 2494 0.241978475330487 3724 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1001 4048-4355 44.4 µM -0.700100896475456 0.265603245652651 no 2495 0.241932148014348 3669 21824233 SGTC_110 0850-0284 111.64 µM -0.702049060449859 0.26500441697545 no 2496 0.241324284131443 3538 3906265 SGTC_1370 2001-0092 44.6 µM -0.702667219119066 0.264814550182703 no 2497 0.241131580551845 3750 790957 SGTC_3290 9121031 71.43 µM -0.703247079110897 0.264636509671768 no 2498 0.240950892194627 3677 17014854 SGTC_1521 st012942 49.4 µM -0.703728398347394 0.264488771423159 no 2499 0.240800965764802 3726 24207259 SGTC_1231 0242-0792 125 µM -0.704180800929573 0.264349947253989 no 2500 0.240660092891587 3678 3707635 SGTC_277 nystatin 15.5 µM -0.704380531644537 0.264288669730965 no 2501 0.240597913359988 3677 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1656 st012921 11 µM -0.704947023616121 0.264114908954441 no 2502 0.240421602471484 3628 6732821 SGTC_734 2023-0417 80 µM -0.705308771835252 0.264003979936532 no 2503 0.240309051383886 3649 3935732 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.706008165764756 0.263789580210841 no 2504 0.240091529673311 3727 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_916 4466-0038 42 nM -0.706234819687628 0.263720118337461 no 2505 0.240021060033945 3740 5722064 YGL116W CDC20 SGTC_2515 chrysin 20.77 µM -0.706523350414178 0.263631706785057 no 2506 0.239931368413787 3694 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_85 0868-0259 160.055 µM -0.708013053831628 0.263175472744166 no 2507 0.239468575540467 3648 83173 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.708715439874592 0.262960501196728 no 2508 0.239250540742212 3710 165521 SGTC_270 tamoxifen 5.46 µM -0.709999561249929 0.262567716536608 no 2509 0.23885220412898 3757 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2480 5767542 37.17 µM -0.710811766269687 0.262319435889136 no 2510 0.238600444156031 3689 2867358 SGTC_2359 9039622 200 µM -0.712123029635211 0.261918853432695 no 2511 0.238194297281194 3661 6463596 SGTC_1288 0973-0013 65.5 µM -0.712757419808751 0.261725163998407 no 2512 0.237997939167562 3721 4315430 SGTC_1223 0764-0573 147 µM -0.714942966320072 0.261058444964295 no 2513 0.237322142991435 3709 1609797 SGTC_2397 5161689 200 µM -0.715088406764426 0.261014108159132 no 2514 0.237277208556043 3743 2259942 SGTC_625 k213-0058 121 µM -0.715674528903612 0.260835470951025 no 2515 0.23709617103035 3768 3655420 SGTC_1458 k015-0034 6.33 µM -0.716458702358853 0.260596570431871 no 2516 0.236854079471947 3719 3598957 SGTC_1935 st074532 41.6 µM -0.717015189994279 0.26042710335635 no 2517 0.236682362005801 3747 2829742 SGTC_2171 5739187 198.077 µM -0.717403953113297 0.260308747082364 no 2518 0.236562440562582 3647 2262761 SGTC_3153 9100258 49.47 µM -0.717816978987727 0.260183034546797 no 2519 0.236435071444335 3661 25236848 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.719667075648427 0.259620305549425 no 2520 0.235865001243463 3707 688798 SGTC_1619 st003326 88.7 µM -0.720604249145721 0.259335492979369 no 2521 0.235576519388177 3667 2849032 SGTC_3137 9097352 49.47 µM -0.721184440644741 0.259159250294496 no 2522 0.235398021753223 3788 44120435 SGTC_1032 k061-1018 98.7 µM -0.721414589055278 0.259089356095488 no 2523 0.235327236596019 3812 4005393 SGTC_1882 5615643 20 µM -0.722396019389103 0.258791413129404 no 2524 0.235025516773923 3651 2253075 SGTC_2504 purpurogallin 52.29 µM -0.723119691937162 0.258571833990843 no 2525 0.234803176048205 3661 5281571 An antioxidant. SGTC_1771 st048882 4.1505 µM -0.723244832180472 0.258533873307234 no 2526 0.234764739828779 3707 4580403 SGTC_2768 sulfasalazine 50.2 µM -0.723524630370537 0.258449008330469 no 2527 0.234678813754596 3725 5384001 An antioxidant and salicylic acid derivative. SGTC_149 3970-0822 46.1 µM -0.723694682434744 0.258397437262362 no 2528 0.234626599232932 3748 3114250 YBL034C STU1 SGTC_1045 1348-1485 165 µM -0.726361539603641 0.257589367220172 no 2529 0.233808581174136 3745 6810614 SGTC_1489 4065-0444 182 µM -0.727218670510141 0.257329931547749 no 2530 0.233546005274794 3686 2877968 SGTC_3351 9150312 21.596 µM -0.728481666404216 0.256947896618003 no 2531 0.233159393751499 3689 4904905 SGTC_403 arphamenine a 50 µM -0.728861017316377 0.256833207027034 no 2532 0.23304334131032 3678 5487158 An arginine aminopeptidase inhibitor. SGTC_2605 digitonin 300 nM -0.730501843433963 0.256337441227767 no 2533 0.232541743289463 3755 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_529 4076-0302 30.3 µM -0.732427804236018 0.255756160640992 no 2534 0.231953746645207 3706 5816522 SGTC_29 0299-0004 12.984 µM -0.73249252005776 0.25573664050224 no 2535 0.231934003265434 3621 16871 A napthoquinone isolated from Swertia calycina. SGTC_1122 capsaicin 818.572 nM -0.733785289143134 0.255346867476982 no 2536 0.231539803861578 3808 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1030 k029-0042 36.7 µM -0.734424743741704 0.255154185201095 no 2537 0.231344955427607 3741 6080581 SGTC_2970 9090938 41.86 µM -0.736251161979894 0.25460426269793 no 2538 0.230788930831132 3723 17217104 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.737393328973231 0.254260679508535 no 2539 0.230441595550658 3729 551469 SGTC_2406 ethylparaben 405.7 µM -0.737523325070812 0.254221589893499 no 2540 0.230402082006397 3758 8434 A possible steroid mimic. SGTC_327 1273-0057 3.96 µM -0.737749412775846 0.254153613195229 no 2541 0.230333369532121 3655 3108138 SGTC_3240 9133527 49.47 µM -0.738188739804322 0.254021550123992 no 2542 0.230199882229792 3708 17617455 SGTC_743 1275-0778 158 µM -0.738344168011934 0.25397483654476 no 2543 0.230152666517465 3747 2849257 YMR203W TOM40 SGTC_2716 st080858 38.6235 µM -0.738434686143959 0.253947633611968 no 2544 0.23012517157223 3721 5296050 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.739490320759558 0.253630502281993 no 2545 0.229804657542023 3727 2333 A French combination drug. SGTC_955 1216-0110 33 µM -0.739575064311167 0.253605052841303 no 2546 0.229778938367061 3695 3619719 SGTC_2863 9028737 58.44 µM -0.740213863714109 0.253413257376568 no 2547 0.229585118340209 3738 6460917 SGTC_2262 9014885 67.46 µM -0.740248797595573 0.253402770899378 no 2548 0.229574521589374 3671 6457424 SGTC_1655 st012546 55.1 µM -0.740759728662019 0.253249425316183 no 2549 0.229419568431837 3692 720985 YLR208W SEC13 SGTC_2806 7952793 58.44 µM -0.740970170526999 0.25318627965437 no 2550 0.229355763501312 3765 2972490 SGTC_2769 toremifene 3.73 µM -0.741537422141048 0.253016110102699 no 2551 0.229183825176728 3752 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2089 5281248 129.67 µM -0.741577286344717 0.253004153522062 no 2552 0.229171744749215 3737 2737878 SGTC_1853 st056710 91.2 µM -0.744337677444583 0.252176945379337 no 2553 0.228336106280277 3831 269167 SGTC_3197 9113331 49.47 µM -0.744607612360717 0.252096130445333 no 2554 0.228254482341646 3752 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1983 st071813 46.9 µM -0.74513580443923 0.251938036272304 no 2555 0.228094813084446 3804 11838595 SGTC_432 NS 1619 61.3 µM -0.745508956598406 0.251826378939912 no 2556 0.227982049324691 3807 4552 A K+/calcium channel activator. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.746600121155742 0.251500022609523 no 2557 0.227652487633392 3809 5024745 SGTC_1519 esterone 74 µM -0.746751217396687 0.251454848868085 no 2558 0.227606873565294 3752 698 A steroid. SGTC_1124 fisetin 1.16336 µM -0.747832409131904 0.251131726573049 no 2559 0.227280625480423 3770 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_656 4090-1979 187 µM -0.749215413446249 0.250718725686033 no 2560 0.226863690261227 3753 22330961 SGTC_1735 st034310 56.75 µM -0.749344059344153 0.250680326984145 no 2561 0.226824929242977 3876 871153 SGTC_2921 7974240 10.71 µM -0.749432587499816 0.250653904583158 no 2562 0.226798257873615 3793 2979074 YDR527W RBA50 SGTC_2743 auranofin 4.32 µM -0.749691253368557 0.250576710779979 no 2563 0.226720338308665 3701 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1003 4049-0218 100 µM -0.750905432432659 0.250214531004979 no 2564 0.226354785373457 3751 295161 SGTC_1805 st050013 60.3 µM -0.751869025826313 0.249927296610564 no 2565 0.226064913363461 3728 4037144 SGTC_3216 9129716 49.47 µM -0.753073496387336 0.249568506168122 no 2566 0.225702874949502 3749 8056934 SGTC_795 0685-0265 78 µM -0.754617269802316 0.249109043848848 no 2567 0.225239329257287 3806 302754 SGTC_3069 9117009 49.47 µM -0.755138617817026 0.248953980441008 no 2568 0.225082907035642 3688 41904981 SGTC_3305 9127027 53.8275 µM -0.75817828586264 0.248050922337653 no 2569 0.224172129300255 3703 41905295 SGTC_950 1165-0508 94.1 µM -0.758268499274632 0.248024147471913 no 2570 0.224145130613723 3789 6148369 SGTC_1779 st039427 55 µM -0.758618951863144 0.247920149620674 no 2571 0.224040266175511 3783 1124498 SGTC_1979 st071809 45.3 µM -0.759095000499258 0.247778918054693 no 2572 0.223897864817808 3875 4976333 SGTC_1412 3909-8563 178 µM -0.75917303592979 0.247755771018611 no 2573 0.223874526834946 3847 23767530 SGTC_1029 k015-0030 64.7 µM -0.75928724410566 0.247721896427066 no 2574 0.223840373195557 3848 2208316 SGTC_839 0122-0028 230 µM -0.760159838582192 0.247463163149265 no 2575 0.223579523997657 3786 759448 SGTC_1147 3809-1045 12.3 µM -0.760209814204561 0.247448349234233 no 2576 0.223564589761356 3755 325925 SGTC_2086 5274770 176.623 µM -0.761512365516578 0.2470624104967 no 2577 0.223175547956294 3824 689278 SGTC_2035 5154463 94.595 µM -0.762844723963913 0.246667973468204 no 2578 0.22277800249791 3760 2769623 SGTC_762 1165-0429 115 µM -0.764058029733868 0.246309074896037 no 2579 0.222416330979043 3732 5967793 SGTC_1419 3993-2473 62.6 µM -0.76717647028473 0.245387918984503 no 2580 0.22148830034342 3839 704026 SGTC_2452 5863136 48.41 µM -0.769855388139258 0.244598074440222 no 2581 0.220692839849982 3760 2184096 SGTC_1944 st076371 56.9 µM -0.771289136616625 0.244175915283667 no 2582 0.220267784994347 3801 24208455 SGTC_2279 7948423 32.93 µM -0.77155602264681 0.24409737559118 no 2583 0.220188714737735 3755 1247112 SGTC_394 menadione 8.33 µM -0.771803437257917 0.244024578153669 no 2584 0.220115427815421 3731 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_299 1273-0059 1.44 µM -0.771948216441474 0.24398198483418 no 2585 0.220072549122671 3727 2848077 SGTC_2796 7949634 45.45 µM -0.773082816119349 0.243648330141282 no 2586 0.219736685062692 3767 2971588 SGTC_729 4092-0585 94.1 µM -0.77403632470113 0.24336812002424 no 2587 0.21945465528151 3786 2169061 SGTC_3106 9121286 49.47 µM -0.777866309973385 0.242244348652883 no 2588 0.218323915652016 3812 15943471 SGTC_2272 7805186 180 µM -0.778012999222017 0.242201363966418 no 2589 0.218280674924934 3781 2956062 YPR165W RHO1 SGTC_2755 lomerizine 42.69 µM -0.778086564837161 0.242179808422558 no 2590 0.21825899127611 3800 3949 A calcium channel blocker. SGTC_2341 7987486 176.74 µM -0.779212113027612 0.241850139994708 no 2591 0.217927387926071 3810 1258686 SGTC_2312 7706453 155.7 µM -0.780210411924339 0.241557946239949 no 2592 0.217633517379881 3838 976098 SGTC_1887 st057648 70.8 µM -0.781083255861844 0.241302629259615 no 2593 0.217376764648029 3838 688672 SGTC_2914 7968218 45.32 µM -0.781192226922159 0.241270764259549 no 2594 0.217344722385791 3793 2977111 SGTC_287 k060-0039 29.6 µM -0.781316397236966 0.241234457525318 no 2595 0.2173082142021 3825 5861974 SGTC_268 camptothecin 39.6153 µM -0.782090734775411 0.241008112391023 no 2596 0.217080625719055 3796 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1932 st074806 40.9 µM -0.782953635395633 0.240756015673497 no 2597 0.21682716965315 3871 17251235 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.783295213878219 0.240656263059488 no 2598 0.216726886571575 3793 688667 SGTC_42 0133-0086 60.653 µM -0.783301645477713 0.240654385028005 no 2599 0.216724998593388 3716 162923 Model of phenazepam hydroxylation. SGTC_1076 itraconazole 331 nM -0.784186500305656 0.240396082872531 no 2600 0.21646534259713 3802 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1452 4194-0072 190 µM -0.785624238365671 0.239976708190632 no 2601 0.216043830035059 3806 1343545 SGTC_2013 4024628 200 µM -0.785804412481463 0.239924181239307 no 2602 0.215991040569283 3830 5230760 SGTC_94 0334-0113 514.748 µM -0.786256440274326 0.239792427195813 no 2603 0.215858633211475 3821 6795178 SGTC_3164 9100705 49.47 µM -0.786365483459196 0.239760649926986 no 2604 0.215826699475743 3811 17174235 SGTC_1729 st035615 45.989 µM -0.786632077160324 0.239682969102221 no 2605 0.215748637967688 3883 17385451 SGTC_446 go6976 132 µM -0.78669670231831 0.239664140509912 no 2606 0.21572971748996 3786 3501 A protein kinase C inhibitor. SGTC_1157 4092-0394 27.6 µM -0.786781668651636 0.239639386728043 no 2607 0.215704843136449 3913 3659885 SGTC_2310 7668677 200 µM -0.787011482820063 0.239572440497971 no 2608 0.215637572127227 3791 2197143 SGTC_1961 st076550 68.7 µM -0.788477799141007 0.23914553434052 no 2609 0.215208639760267 3816 1579337 SGTC_1558 st069300 45.6 µM -0.788612098973271 0.239106454822505 no 2610 0.215169378638833 3741 24208000 SGTC_873 0591-4978 488 µM -0.789607846686931 0.23881681399728 no 2611 0.214878412149806 3841 3305145 SGTC_2827 7993847 71.43 µM -0.789766407468717 0.23877070991827 no 2612 0.214832100359071 3863 2985692 SGTC_2453 5731132 22.18 µM -0.790132062882272 0.238664408332241 no 2613 0.214725323314546 3840 1362040 SGTC_1390 3413-2614 145 µM -0.791385607484942 0.238300180514135 no 2614 0.214359503034739 3870 3421432 SGTC_967 1306-0166 352 µM -0.791401059685956 0.238295692648971 no 2615 0.214354995901905 3767 4437607 SGTC_1403 3909-7815 62.9 µM -0.794012402539897 0.237537931782358 no 2616 0.213594105558668 3772 6615483 SGTC_1692 fluoroquinolonic acid 71 µM -0.794217143826126 0.237478575807653 no 2617 0.213534514860351 3860 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1372 2752-0194 270 µM -0.79457106763763 0.23737598994761 no 2618 0.21343152689548 3788 823334 SGTC_3178 9107506 49.47 µM -0.796710592796149 0.236756360716136 no 2619 0.212809565250821 3853 8897194 SGTC_3347 9188721 44.724 µM -0.796734471005818 0.236749450355668 no 2620 0.212802629811611 3869 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_954 1189-0853 2.85 µM -0.797088785913604 0.236646924559773 no 2621 0.212699734355783 3799 2828194 SGTC_2285 7945142 200 µM -0.797843807260677 0.23642853045602 no 2622 0.212480567961149 3869 2970608 SGTC_929 2805-0021 398 µM -0.798011001074882 0.236380183727795 no 2623 0.212432053054767 3906 3098024 SGTC_9 0092-0002 10.449 µM -0.798949763245615 0.236108826936569 no 2624 0.212159771090972 3800 759368 SGTC_3012 9080433 71.4286 µM -0.801886474813731 0.235261055888602 no 2625 0.211309315262003 3828 17688859 SGTC_1912 st060209 90.8 µM -0.802083396362374 0.235204268688014 no 2626 0.211252359380071 3864 688787 SGTC_3266 9136860 49.47 µM -0.8033544661938 0.234837906421231 no 2627 0.21088494261135 3747 4871271 YPR165W RHO1 SGTC_1927 st060202 13.8 µM -0.803787554808156 0.234713148756552 no 2628 0.210759839205925 3755 688887 SGTC_1984 st072354 53.1 µM -0.804367180713987 0.234546236186351 no 2629 0.210592474690526 3756 5762938 SGTC_1475 4092-1048 11.7 µM -0.804677567449733 0.234456882351038 no 2630 0.210502883912147 3866 2881759 SGTC_1647 st011722 22.4 µM -0.804838979354415 0.234410422691824 no 2631 0.210456302432061 3798 2854783 SGTC_1925 st057770 10.1 µM -0.807180737224467 0.233736961079852 no 2632 0.209781180986693 3835 5989122 SGTC_275 trichlorophene 5.69 µM -0.807282950539136 0.233707590198854 no 2633 0.209751742237934 3888 62616 SGTC_2019 4016004 108 µM -0.808135801665398 0.233462604157417 no 2634 0.209506204847014 3865 45595336 SGTC_1976 st070609 63.5 µM -0.809266912468928 0.233137906403208 no 2635 0.209180816967305 3759 682556 SGTC_2144 5628481 200 µM -0.811924965516206 0.232375870857909 no 2636 0.208417344033136 3839 2818399 SGTC_2519 cryptotanshinone 88.04 µM -0.812434549437509 0.232229937000913 no 2637 0.208271164135902 3796 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2257 7960413 200 µM -0.812593731558102 0.232184361126636 no 2638 0.208225513350514 3835 2974689 YIL048W NEO1 SGTC_1264 0783-0040 158 µM -0.814214424734902 0.231720619418968 no 2639 0.20776106165695 3768 2855798 SGTC_1179 1021-1431 9.29 µM -0.814951792015073 0.231509801648018 no 2640 0.207549952622305 3890 2840958 SGTC_1794 st048918 76.9 µM -0.815238447261243 0.231427874050455 no 2641 0.207467917153556 3752 672303 SGTC_2724 maprotiline 69.64 µM -0.816162538333989 0.231163873988824 no 2642 0.207203589766253 3792 4011 A tricyclic antidepressant. SGTC_322 k048-0136 19.3 µM -0.81678873642386 0.230985073399319 no 2643 0.207024585079823 3908 6823282 SGTC_2351 9026858 72.31 µM -0.817549159900135 0.230768050791885 no 2644 0.206807333855953 3797 1409300 SGTC_2307 7538926 6.34 µM -0.818768093941501 0.230420408350057 no 2645 0.206459368926891 3889 96582 SGTC_462 ag-879 158 µM -0.818881791944598 0.230387996385751 no 2646 0.206426929642787 3893 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1636 st007707 68.9 µM -0.818896725091247 0.230383739573231 no 2647 0.206422669277062 3863 403051 SGTC_974 1326-0144 138 µM -0.81895748534079 0.230366419833105 no 2648 0.206405335163368 3906 5411856 SGTC_2226 7298446 200 µM -0.826376987281382 0.228256967105796 no 2649 0.204295136775844 3837 3283010 SGTC_384 k007-0144 5.16 µM -0.826781768139669 0.228142196281428 no 2650 0.204180382792586 3854 6824886 SGTC_775 4577-0580 57.3 µM -0.827171975298798 0.22803158838082 no 2651 0.204069796751872 3956 2006902 SGTC_1385 3091-4834 14.1 µM -0.829090899248656 0.22748809036412 no 2652 0.203526486542374 3870 4072814 SGTC_2401 5128683 200 µM -0.829873995848189 0.227266503223168 no 2653 0.203305014369139 3859 708373 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.830373397575487 0.227125254694426 no 2654 0.203163850751808 3901 688664 SGTC_1587 estradiol valerate 56.1 µM -0.830381455534916 0.227122976023343 no 2655 0.203161573524788 3915 13791 A steroid. SGTC_2216 7189485 200 µM -0.830614299659341 0.227057136734874 no 2656 0.203095776979117 3881 731273 SGTC_2327 6189656 200 µM -0.830642882777998 0.227049055279031 no 2657 0.203087700905424 3956 5349088 SGTC_2666 tannic acid 100 µM -0.831577770132017 0.22678481906538 no 2658 0.202823657022321 3883 16134267 A thiamine antagonist. SGTC_1973 st070275 50.2 µM -0.832019683215388 0.226659977330776 no 2659 0.202698917203053 3771 17118334 SGTC_1314 1222-0010 41.1 µM -0.832890771797157 0.22641400588285 no 2660 0.202453167321488 3887 3526027 SGTC_1833 st055984 71 µM -0.833728355237784 0.226177637588019 no 2661 0.202217037927857 3909 676288 SGTC_711 k292-0785 179 µM -0.833873395095263 0.226136721118835 no 2662 0.202176165401888 3859 4146315 SGTC_2329 6138490 200 µM -0.834136169813269 0.226062601712168 no 2663 0.202102127543893 4007 720019 SGTC_629 3448-6466 76.7 µM -0.83513718037036 0.225780378038667 no 2664 0.201820237356067 3872 573744 SGTC_2935 9038016 29.96 µM -0.837630130425506 0.225078385683991 no 2665 0.201119232630096 3904 6463195 SGTC_1885 st057546 99.9 µM -0.838494035112535 0.224835406727481 no 2666 0.200876648184982 3953 702008 SGTC_1207 2099-0101 141 µM -0.839387091431065 0.224584385081137 no 2667 0.200626062612689 3917 5837381 SGTC_824 1304-0008 100 µM -0.840238708021405 0.224345159546357 no 2668 0.200387279653493 3914 768245 SGTC_3345 9148410 3.559 µM -0.840642258854693 0.224231849599806 no 2669 0.200274188538365 3852 4903596 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.841472365313312 0.22399887256737 no 2670 0.200041680054699 3890 2724 A muscle relaxant with antifungal properties. SGTC_2744 captopril 92.04 µM -0.841827024513469 0.223899376138009 no 2671 0.199942391362481 3850 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2531 methyl deoxycholate 70.07 µM -0.841929884083278 0.223870524515339 no 2672 0.19991360083406 3861 16667744 Haematoxylin. SGTC_1772 st048439 82.2 µM -0.842117924985274 0.223817785394451 no 2673 0.199860974384251 3939 2927068 YDL195W SEC31 SGTC_1313 1220-0047 237 µM -0.842616845315064 0.223677889326232 no 2674 0.199721383417344 3879 3528706 SGTC_2661 dactinomycin 12.96 µM -0.843141001476805 0.223530970759612 no 2675 0.199574795014002 3869 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_103 0844-0104 51.839 µM -0.845023040248678 0.223003896534238 no 2676 0.199048987545251 3875 5375804 SGTC_1921 5740136 50 µM -0.845088900841208 0.222985464778372 no 2677 0.199030602419699 3806 1774243 SGTC_561 1550-0330 72.9 µM -0.846104056249061 0.222701473007155 no 2678 0.198747349065057 3845 6812934 SGTC_2742 clothiapine 36.27 µM -0.848038713243577 0.222160820015894 no 2679 0.198208205557504 3841 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_402 epigallocatechin gallate 10 µM -0.849057436237502 0.22187643232277 no 2680 0.197924666553975 3868 65064 An antioxidant. SGTC_2759 disulfiram 3.38 µM -0.851534634321486 0.221185763489808 no 2681 0.197236216262157 3826 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1081 sertraline 6 µM -0.855149555764436 0.220180095822858 no 2682 0.19623417911225 3909 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2941 9056145 11.23 µM -0.857424597000485 0.219548528340378 no 2683 0.195605135187062 3770 2119517 SGTC_3330 9141424 71.43 µM -0.857844546209036 0.219432061348697 no 2684 0.195489154149599 3990 27261020 SGTC_2588 indole-3-carbinol 100 µM -0.858385479722393 0.219282093388923 no 2685 0.195339821382602 3969 3712 Induces cell cycle arrest. SGTC_1505 k297-0037 20.6 µM -0.858800859229867 0.219166973914176 no 2686 0.195225196726799 3929 4089396 SGTC_276 colchicine 750 µM -0.861037828586056 0.218547611482127 no 2687 0.194608604421436 3994 2833 A microtubule depolymerizer. SGTC_2639 lactacystin 53 µM -0.861881381154984 0.218314314208577 no 2688 0.194376397853125 3951 3870 A proteasome inhibitor. SGTC_60 0986-0278 202 µM -0.862028007935869 0.218273776987278 no 2689 0.194336052792596 3852 3110598 SGTC_1346 1488-2224 62.4 µM -0.864446595687906 0.217605747341795 no 2690 0.193671302706038 3886 3722427 SGTC_2263 7948595 193.29 µM -0.865941808706197 0.217193350646189 no 2691 0.193261037045483 3896 2971371 SGTC_1609 st001574 46.4 µM -0.866704147412231 0.216983262883579 no 2692 0.193052066217617 3909 3960012 SGTC_2428 5615643 7.78 µM -0.867281217914257 0.216824310062711 no 2693 0.192893972539988 3969 2253075 SGTC_3314 9135860 59.4275 µM -0.870147462001573 0.216035807623132 no 2694 0.192109911517681 3889 25252478 SGTC_1278 0874-0585 172 µM -0.87284924375498 0.215294071792139 no 2695 0.191372627308902 3995 766306 SGTC_2829 7992743 58.44 µM -0.8740323514296 0.214969732198507 no 2696 0.191050317920551 3978 16462845 SGTC_1807 st050092 58.9 µM -0.874700631586726 0.214786653968685 no 2697 0.190868408192522 3968 5008496 SGTC_2563 tomatine 8.54 µM -0.875399810517037 0.214595207889704 no 2698 0.190678201429437 3830 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1859 st055998 20 µM -0.876563542670184 0.214276779938546 no 2699 0.190361874268436 3884 676301 SGTC_2799 7812892 81.82 µM -0.876583093163827 0.214271432754098 no 2700 0.190356562782612 3970 20205235 SGTC_1417 3966-0327 90.4 µM -0.876675583416801 0.214246137133473 no 2701 0.190331436228139 4011 651118 SGTC_1143 3454-2408 5.08 µM -0.879706936190146 0.213418039341475 no 2702 0.189509045439936 3868 X1143 SGTC_2497 7-hydroxyflavone 100 µM -0.879753882829406 0.213405229257516 no 2703 0.189496326270093 3972 5281894 SGTC_447 ml7 120 µM -0.880058482700952 0.213322125572101 no 2704 0.189413814327676 3963 4216 Selective myosin light chain kinase inhibitor. SGTC_109 0132-0036 33.701 µM -0.882873042554493 0.212555125077487 no 2705 0.188652435056732 3764 67274 A color developer. SGTC_540 1187-0821 17.3 µM -0.884235879048297 0.212184315735701 no 2706 0.188284446930786 3897 847520 SGTC_608 k048-0125 159 µM -0.884253857510191 0.212179426568505 no 2707 0.18827959541372 3985 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2812 7970281 58.44 µM -0.884668316581367 0.21206673442564 no 2708 0.188167774345895 4002 2233435 SGTC_2844 9010103 25.97 µM -0.884956409996741 0.211988421948319 no 2709 0.188090070885368 4016 2480525 SGTC_3202 9113761 49.47 µM -0.887310576483089 0.211349122608011 no 2710 0.187455856437261 3989 4798415 SGTC_2525 harmine 47.85 µM -0.889428997677544 0.210774808951566 no 2711 0.186886283208623 3951 5280953 A monoamine oxidase inhibitor SGTC_2891 9063876 19.48 µM -0.893066295556719 0.209790858842177 no 2712 0.185910835539258 3951 6472478 SGTC_3042 9091578 49.47 µM -0.893989548615896 0.209541533778854 no 2713 0.18566374155852 3921 25236497 SGTC_1085 doxorubicin 7.67 µM -0.894698103056464 0.209350306478972 no 2714 0.185474246505533 3976 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2060 5238662 140 µM -0.895542685829159 0.20912250156948 no 2715 0.185248529066807 3957 790130 SGTC_799 1310-0557 151 µM -0.896060038346517 0.208983030887332 no 2716 0.185110349241566 4039 5354492 SGTC_2488 5268135 45.7 µM -0.899200637932242 0.208137547628944 no 2717 0.184272900308391 4024 1270356 YLR208W SEC13 SGTC_3114 9122766 49.47 µM -0.900041877181939 0.207911420204039 no 2718 0.184048982656324 3972 17176985 SGTC_646 4092-0839 27.3 µM -0.902004529948562 0.207384418087373 no 2719 0.183527230687523 4029 877796 SGTC_2162 5663267 200 µM -0.903284192179772 0.207041235033564 no 2720 0.183187542034015 3939 6456493 SGTC_2252 omeprazole 400 µM -0.903673306550512 0.206936948014775 no 2721 0.183084328720367 3923 4594 A proton pump inhibitor. SGTC_810 3825-7150 143 µM -0.904090819175452 0.206825084525547 no 2722 0.182973623072621 4045 22330411 YGL099W LSG1 SGTC_1335 1486-0900 202 µM -0.907084937345786 0.206023924605357 no 2723 0.18218094139141 3969 X1335 SGTC_1129 3453-1384 223 µM -0.908125702677928 0.205745870421791 no 2724 0.181905906114759 4111 1084452 SGTC_577 r071-0003 38.6 µM -0.90836493791819 0.205681987064917 no 2725 0.18184272193041 4010 4568517 YMR134W ERG29 SGTC_2362 9071156 126 µM -0.908624900292675 0.205612582257929 no 2726 0.181774079088029 4030 653133 SGTC_1491 4138-0063 26.5 µM -0.910662453227279 0.205069077644771 no 2727 0.181236626551181 3924 23883227 SGTC_2205 7238770 200 µM -0.91075167914952 0.205045296714475 no 2728 0.181213113881952 4040 279867 SGTC_2638 epoxomicin 18 µM -0.912548162619042 0.204566837969346 no 2729 0.180740114037338 3979 9915668 A protesome inhibitor. SGTC_2298 7976326 193.81 µM -0.914569380148256 0.204029320600244 no 2730 0.180208869748208 3853 2235818 SGTC_1967 st070177 51.4 µM -0.918379544651614 0.203018346384808 no 2731 0.179210097978522 4031 5729214 SGTC_1327 1436-0082 2.18 µM -0.919480654599442 0.202726740252233 no 2732 0.178922109870278 3980 15992205 SGTC_2492 derrusnin 100 µM -0.919533671636876 0.202712706107791 no 2733 0.178908250964005 3908 1715307 Part of coumarin class of compounds. SGTC_2006 4011487 200 µM -0.920489714725921 0.202459731501473 no 2734 0.178658452690188 4044 45595294 SGTC_1038 k292-0204 154 µM -0.920920727155586 0.202345744844107 no 2735 0.178545908117764 3942 4454212 SGTC_3297 9117502 71.43 µM -0.921589385763498 0.202168985643316 no 2736 0.178371398535599 4013 7453720 SGTC_46 0329-0187a 2.197 µM -0.922454398231404 0.20194045761522 no 2737 0.178145803120098 4056 46494817 SGTC_733 4069-0007 56.1 µM -0.926680817700751 0.200826103380328 no 2738 0.177046139974804 3994 5717425 YNL287W SEC21 SGTC_369 0957-0393 4.5 µM -0.929183755210626 0.200167912482716 no 2739 0.176396932342898 4040 6997992 SGTC_399 oxolinic acid 75 µM -0.93487774199849 0.198675417260709 no 2740 0.174925654506402 3977 4628 A DNA gyrase inhibitor. SGTC_532 1548-0774 215 µM -0.93537761650481 0.198544712465705 no 2741 0.174796864057453 4146 5932993 SGTC_3056 9094900 49.47 µM -0.935403133141048 0.198538041889425 no 2742 0.174790291424336 3997 25236784 SGTC_429 1112-0049 25.5 µM -0.935966992760378 0.198390671829986 no 2743 0.174645091219189 3975 2836170 SGTC_2659 sanguinarine 24.21 µM -0.937224966873401 0.198062126353995 no 2744 0.174321424836204 3944 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1715 st032160 10.2275 µM -0.938870811343464 0.197632777129154 no 2745 0.173898538506321 3969 5289825 SGTC_3209 9113616 49.47 µM -0.940250763064564 0.197273224924833 no 2746 0.173544474390845 4078 16649353 SGTC_1685 st024049 53.0905 µM -0.942834866556534 0.196600991104357 no 2747 0.172882687283351 4042 1941139 SGTC_246 cycloheximide 667 µM -0.942965866613203 0.196566949489629 no 2748 0.172849181144482 3891 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_3313 9133968 57.047 µM -0.944358012311875 0.196205407820887 no 2749 0.172493365041062 4010 1494643 SGTC_2103 5378138 10 µM -0.946431131952587 0.195667764415552 no 2750 0.171964366420704 4073 244142 SGTC_2886 9058944 51.95 µM -0.948318038087208 0.195179191985237 no 2751 0.17148378534296 3877 4949929 SGTC_2549 cedrol 20.94 µM -0.948407498961328 0.195156046502754 no 2752 0.171461021649711 3971 6708665 A sedative which affects the nervous system. SGTC_207 4185-0010 4.486 µM -0.949894978847756 0.194771447465086 no 2753 0.171082809214337 4076 3761753 SGTC_879 0831-1030 162 µM -0.950437851876719 0.19463119850266 no 2754 0.170944909209859 4060 1549252 SGTC_2237 6667747 47.222 µM -0.951934930612244 0.19424475301629 no 2755 0.170564991505787 4030 729940 YDL015C TSC13 SGTC_2126 5251174 33.877 µM -0.954170564333409 0.193668532747424 no 2756 0.169998655988688 4065 790722 SGTC_3238 9133470 49.47 µM -0.955088730697699 0.193432183499243 no 2757 0.169766413698575 4037 3534688 SGTC_3205 9113483 49.47 µM -0.958170934451143 0.19264006756565 no 2758 0.168988285539578 4106 17018033 SGTC_1939 st074455 53.6 µM -0.958592195596425 0.192531959074903 no 2759 0.168882112862994 4076 1644229 SGTC_2292 7671323 168.05 µM -0.960653589497685 0.192003477328462 no 2760 0.168363186967932 4108 937504 SGTC_3071 9117417 49.47 µM -0.961700763773543 0.191735352520565 no 2761 0.168099969298452 3986 45595590 YGL055W OLE1 SGTC_1470 k295-0292 231 µM -0.965981099910979 0.190641775404186 no 2762 0.167026819259725 4121 5045612 SGTC_470 aa-861 153 µM -0.967059583332124 0.190366840202287 no 2763 0.166757124237897 4037 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1797 st048695 56.8 µM -0.967593041767771 0.19023093698248 no 2764 0.166623826863846 4032 592262 YIL048W NEO1 SGTC_1928 4'-methoxychalcone 40.3 µM -0.968040369222228 0.190117022346093 no 2765 0.166512104403275 4096 641818 SGTC_2141 5621638 7.665 µM -0.968322320964782 0.190045243175265 no 2766 0.166441710276113 4078 2856238 SGTC_1204 4049-0315 18.3 µM -0.968905989517077 0.18989670598763 no 2767 0.166296048395553 4147 588402 SGTC_2906 7926292 26.41 µM -0.970714927879248 0.189436804778389 no 2768 0.165845128049448 4082 2966319 SGTC_2182 6325192 200 µM -0.971320085270945 0.189283103801779 no 2769 0.165694454956487 3972 736248 SGTC_2159 5658611 73.75 µM -0.97135915867136 0.18927318237847 no 2770 0.165684729439241 4041 793844 SGTC_2315 7733312 200 µM -0.971737998766106 0.189177004819044 no 2771 0.165590453844801 3971 726316 SGTC_736 0958-0254 92.6 µM -0.973556104932866 0.188715854265931 no 2772 0.165138495062435 4153 6812352 SGTC_1166 k206-0078 225 µM -0.973568201696804 0.188712788324372 no 2773 0.165135490632612 4052 5404595 SGTC_2702 st077768 96.8 µM -0.973611814948194 0.188701734740351 no 2774 0.165124658859718 4047 6484119 SGTC_1321 1326-2144 215 µM -0.976031987371715 0.188088978497904 no 2775 0.164524306558755 4078 3513030 SGTC_2003 4023581 200 µM -0.976345720076147 0.188009635467207 no 2776 0.164446585170148 4105 16641307 SGTC_2947 9072639 7.68 µM -0.976611384007904 0.187942465191881 no 2777 0.164380790529828 4093 16488146 SGTC_3132 9126706 49.47 µM -0.978285678563498 0.187519478796611 no 2778 0.163966525540197 4152 850858 SGTC_169 k015-0017 16.025 µM -0.978686641833641 0.187418268583817 no 2779 0.16386741718871 4017 1840002 SGTC_1149 3909-7961 23.3 µM -0.979074787269913 0.187320325988478 no 2780 0.163771514132988 4097 735261 SGTC_48 0382-0018 55 µM -0.981043097945619 0.186824139994079 no 2781 0.163285744442471 4093 762596 SGTC_953 1188-0045 9.7 µM -0.982233769673179 0.18652438208909 no 2782 0.162992347231119 4099 6144426 SGTC_2905 7799065 20.05 µM -0.982433168861302 0.186474211421905 no 2783 0.162943246165862 3990 1296806 SGTC_1581 himbacine 57.9 µM -0.982785929788651 0.186385474007636 no 2784 0.162856404088082 4064 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3231 9132313 49.47 µM -0.983286041320649 0.186259715220343 no 2785 0.162733339080887 4037 4905967 SGTC_882 0843-0131 351 µM -0.983599393587347 0.186180945993953 no 2786 0.162656261713566 4058 5425421 SGTC_2521 angolensin 13.4 µM -0.985574880159844 0.185684831636461 no 2787 0.162170884882954 4136 821428 A flavenoid. SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.985850295733844 0.185615730273389 no 2788 0.162103290293049 4106 94937 An inhibitor of serotonin biosynthesis. SGTC_3320 9137005 35.139 µM -0.986999668600374 0.185327526587433 no 2789 0.161821400530449 4089 4908713 SGTC_875 0709-0210 25.7 µM -0.987475972875599 0.185208175406676 no 2790 0.161704678057281 4091 6251364 SGTC_81 0411-0046 9.971 µM -0.987710042438319 0.185149540315159 no 2791 0.161647337404768 4019 12925265 SGTC_1606 st000094 49.2 µM -0.98851440636717 0.184948132766335 no 2792 0.161450391243813 4103 1242210 SGTC_2825 7998094 58.44 µM -0.989799177839346 0.184626716775753 no 2793 0.161136143387931 4086 2987815 SGTC_2050 5263056 171 µM -0.990451367525685 0.184463689081547 no 2794 0.160976774289109 4091 763468 YGL055W OLE1 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.990956341531006 0.184337522381325 no 2795 0.160853449509968 4160 4213774 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.994517216984902 0.183449369997768 no 2796 0.159985563821797 4169 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2747 doxorubicin 7.63 µM -0.995877025437241 0.183110912027898 no 2797 0.159654949688153 4039 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2123 5259487 200 µM -0.996733430930101 0.182897951715943 no 2798 0.159446958984795 4099 2173474 SGTC_1836 st055642 81 µM -0.996758642453789 0.182891684769569 no 2799 0.15944083868357 4091 8571 SGTC_2286 7945697 125 µM -1.00018984713714 0.182040024727345 no 2800 0.158609320842681 4123 1245733 SGTC_898 1000-0849 28.3 µM -1.00094252091821 0.181853535554563 no 2801 0.158427298938812 4087 6751807 SGTC_96 0929-0093 37.281 µM -1.0013268770826 0.181758350148643 no 2802 0.158334401529537 4080 6991579 SGTC_1272 0839-0021 27 µM -1.00150057102244 0.181715345251577 no 2803 0.158292432098223 4103 5027250 SGTC_1872 amphotericin b 148 nM -1.00172962349957 0.181658643863514 no 2804 0.158237097619441 4110 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2981 9013952 38.96 µM -1.00317522183565 0.181301044952571 no 2805 0.157888162979827 4064 2996344 SGTC_2130 NSC 7 2.4545 µM -1.00376892618457 0.181154307578326 no 2806 0.157745002701281 4163 21448 SGTC_2520 obtusaquinone 4.71 µM -1.00578581522216 0.180656377930675 no 2807 0.157259306072231 4157 5967872 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.00671299498646 0.180427763975717 no 2808 0.157036357750861 4097 77254 SGTC_1142 3253-1408 9.78 µM -1.0068879676374 0.180384641478513 no 2809 0.15699430740785 4105 256655 SGTC_658 3253-0951 102 µM -1.00772728348194 0.180177879664991 no 2810 0.156792701623063 4103 1184878 SGTC_324 1315-0088 19.6 µM -1.00854411699704 0.179976799171403 no 2811 0.156596659809613 4065 6787421 SGTC_1691 st019933 84.6 µM -1.01025062072976 0.179557162856092 no 2812 0.156187616148739 4087 6176082 SGTC_1600 coumarin 106 71.1 µM -1.0104932902098 0.17949753940905 no 2813 0.156129506246967 4169 100336 A hepatotoxic, DNA x-linker. SGTC_1154 4088-0362 150 µM -1.01173649196681 0.179192282235993 no 2814 0.155832031243454 4093 6618304 SGTC_939 1165-0479 45.3 µM -1.01187759247451 0.179157656901442 no 2815 0.155798292151001 4091 1377347 SGTC_2746 daunorubicin 9.88 µM -1.01356889295383 0.178742948125308 no 2816 0.155394253593381 4035 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3131 9127911 49.47 µM -1.01374631959704 0.178699477966419 no 2817 0.155351907852723 4168 45595681 SGTC_761 k216-0224 480 µM -1.01447115739996 0.178521959276326 no 2818 0.155178992685669 4141 1340404 SGTC_1992 st073643 23.3 µM -1.0152012047672 0.178343277036524 no 2819 0.155004963216326 4079 3161292 SGTC_2625 euphol 100 µM -1.01526874817235 0.178326751194106 no 2820 0.154988868663699 4139 6708538 A triterpene alcohol. SGTC_3101 9120531 49.47 µM -1.0153363260139 0.17831021789183 no 2821 0.154972767009896 4126 24824904 SGTC_2593 nobiletin 86.24 µM -1.0173038284395 0.177829280763734 no 2822 0.154504457962556 4128 72344 An anti-infammatory. SGTC_98 0074-0023 107.663 µM -1.0184253059606 0.177555512787175 no 2823 0.154237940533779 4132 3563821 SGTC_903 1134-0042 114 µM -1.01868049557826 0.177493254686743 no 2824 0.154177337598516 4127 701009 SGTC_2534 helenine 20.12 µM -1.01957181894818 0.177275908441271 no 2825 0.153965787954019 4102 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2370 9071495 200 µM -1.02103303056003 0.176919960629461 no 2826 0.153619394876249 4118 21791103 SGTC_2339 9000433 200 µM -1.02160939539886 0.176779683771685 no 2827 0.15348290453961 4139 2988954 SGTC_737 1950-0117 57.9 µM -1.02278782978919 0.176493092898153 no 2828 0.153204086741187 4090 5393513 SGTC_3312 9133330 71.43 µM -1.02599661731123 0.175714218263291 no 2829 0.152446589269307 4158 17617324 SGTC_1414 3917-0015 5.4 µM -1.02641509561864 0.175612801047049 no 2830 0.152347982758527 4086 6618702 SGTC_2191 5911152 200 µM -1.02810870212261 0.175202738485178 no 2831 0.151949348827723 4121 2875902 SGTC_2261 9010538 184.68 µM -1.02992889408177 0.174762704192883 no 2832 0.151521692937212 4126 6457250 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.02996515112575 0.174753946127472 no 2833 0.151513182445585 4129 229346 A bile salt which induces apoptosis. SGTC_1948 st076329 66.6 µM -1.03281500515265 0.1740664217546 no 2834 0.150845240143922 3981 24208413 SGTC_1354 1498-1681 81 µM -1.03318617093164 0.173977005116228 no 2835 0.150758391648717 4137 5754243 SGTC_2431 5490079 200 µM -1.0341974382974 0.17373353138741 no 2836 0.150521935744969 4171 5722345 SGTC_2041 5107442 45.335 µM -1.03455549885259 0.173647376359357 no 2837 0.150438272793187 4177 793005 SGTC_712 r015-0009 80.6 µM -1.03475602525969 0.173599138413654 no 2838 0.150391432156181 4161 6813872 YLR060W FRS1 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.03532007467264 0.173463498347876 no 2839 0.150259728885262 4174 91467 include heat shock SGTC_2122 5258151 111.688 µM -1.03615882458024 0.173261924312782 no 2840 0.150064026327663 4124 2173356 SGTC_645 0845-0943 5.41 µM -1.04054459954254 0.172210335647071 no 2841 0.149043477314215 4130 1885106 SGTC_2008 4012253 172 µM -1.04068176137543 0.172177513811351 no 2842 0.149011635349598 4126 603940 SGTC_290 2043-6722 48.1 µM -1.0428364142352 0.17166244493548 no 2843 0.148512031547561 4162 773758 YLR208W SEC13 SGTC_2748 diazoxide 86.69 µM -1.0441564454594 0.171347378779545 no 2844 0.148206507117253 4183 3019 A potassium channel activatior. SGTC_3337 9144342 33.5465 µM -1.04424961696439 0.171325154502036 no 2845 0.148184958246451 4131 17682949 SGTC_1055 3448-0672 86 µM -1.04432245295788 0.171307782154613 no 2846 0.148168114068844 4152 748378 SGTC_2149 5554786 194.827 µM -1.04525851804768 0.171084618499525 no 2847 0.147951752074368 4158 745063 YPR165W RHO1 SGTC_3093 9117344 49.47 µM -1.04603112642324 0.170900564063217 no 2848 0.147773330844797 4179 24824913 SGTC_2073 5212005 126 µM -1.04851535786377 0.170309617621867 no 2849 0.14720061511729 3941 691789 SGTC_1938 st074717 56.4 µM -1.05015500906396 0.169920297047317 no 2850 0.146823425460304 4035 17250979 SGTC_2077 5212015 200 µM -1.05104160447987 0.169710020721833 no 2851 0.146619741043216 3994 780900 SGTC_3327 9140648 26.9345 µM -1.05140586698824 0.169623675952009 no 2852 0.146536111187625 4172 8029710 SGTC_301 4119-0100 24.5 µM -1.05227683269613 0.169417336546533 no 2853 0.146336278798133 4168 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_862 0452-0056 10.2 µM -1.056408924806 0.168440603831944 no 2854 0.145390715138347 4098 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_807 1315-0151 48 µM -1.05849318622793 0.167949308401794 no 2855 0.144915327782274 4186 4011080 SGTC_519 k048-0011 62.8 µM -1.0620118993581 0.167121983854489 no 2856 0.144115141608899 4194 6836379 SGTC_890 0929-0006 47.2 µM -1.06217989603431 0.167082550081855 no 2857 0.144077012354718 4123 1378169 SGTC_2360 9040895 200 µM -1.06418124349357 0.166613236357661 no 2858 0.143623301101805 4178 4914414 SGTC_2546 rhodinyl acetate 100 µM -1.06805266586305 0.165707809377822 no 2859 0.142748377887514 4119 6708682 SGTC_798 1287-0182 476 µM -1.0696710894024 0.165330246124726 no 2860 0.142383691979842 4200 1649755 SGTC_1260 0700-1617 7.75 µM -1.07032764182719 0.165177237351632 no 2861 0.142235928232921 4156 2853078 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.07168101415227 0.164862124809005 no 2862 0.141931665640966 4184 115019 SGTC_806 3966-4455 5.86 µM -1.07188038033458 0.164815738292982 no 2863 0.141886881782095 4154 714982 SGTC_3081 9117243 49.47 µM -1.07197864140718 0.164792879006361 no 2864 0.141864812802787 4149 45595589 SGTC_2967 9089538 49.85 µM -1.07250642334383 0.164670131868327 no 2865 0.141746315210271 4181 728216 SGTC_1210 3013-0140 750 nM -1.07436131845961 0.164239205853951 no 2866 0.141330386122721 4199 905973 SGTC_2790 5423970 71.43 µM -1.07490407377449 0.164113252300615 no 2867 0.141208838960473 4229 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_887 0885-0007 9.62 µM -1.07559254072021 0.16395357460181 no 2868 0.141054762447477 4241 5719458 SGTC_2995 9067767 71.4286 µM -1.07728126799761 0.163562331297505 no 2869 0.1406773141062 4182 11673567 SGTC_3027 9089541 49.47 µM -1.07889383073076 0.163189300075101 no 2870 0.140317529673328 4183 9943819 SGTC_2459 5811157 9.22 µM -1.07910889284112 0.163139591961275 no 2871 0.14026959369338 4141 2870684 YBR192W RIM2 SGTC_822 1487-0950 154 µM -1.07985781270865 0.162966568105098 no 2872 0.14010275101746 4183 1958375 SGTC_2048 5246248 200 µM -1.08008392790033 0.162914351896928 no 2873 0.140052404095022 4197 677046 SGTC_376 3970-0862 59.1 µM -1.08226835519562 0.16241046787508 no 2874 0.139566651446047 4215 3135186 SGTC_1242 0402-0103 60.1 µM -1.08525040040498 0.161724235807236 no 2875 0.138905383585596 4101 432868 SGTC_3234 9132280 49.47 µM -1.0853182583215 0.16170864227814 no 2876 0.138890360974308 4209 17612295 SGTC_836 0330-0104 1.35 µM -1.08588283153576 0.161578943178469 no 2877 0.138765416770225 4200 46494820 SGTC_1832 st054113 55 µM -1.0878046132813 0.161137961750405 no 2878 0.138340686256106 4186 1251267 SGTC_1468 k284-1086 134 µM -1.088066441525 0.161077942201872 no 2879 0.138282888593135 4164 15996457 SGTC_55 0767-0285 6.563 µM -1.09114901234759 0.160372413800174 no 2880 0.13760365964698 4101 3116166 SGTC_323 4013-0906 34.3 µM -1.09114905401672 0.160372404276753 no 2881 0.137603650480815 4203 2910086 SGTC_2692 st077426 47.7 µM -1.09167739193251 0.16025168310596 no 2882 0.137487462880554 4212 25238571 SGTC_1778 st046819 58.9 µM -1.09212014488788 0.160150563199493 no 2883 0.137390147995374 4230 671715 SGTC_727 3032-0951 202 µM -1.09266780469224 0.160025541446015 no 2884 0.137269840193984 4222 3652836 SGTC_569 4130-2812 160 µM -1.09460416527512 0.159584013960892 no 2885 0.136845044996044 4008 743552 SGTC_2876 9059903 25.97 µM -1.09517544141999 0.159453904460257 no 2886 0.136719891326609 4178 6916095 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.09546549936164 0.159387869662791 no 2887 0.13665637616119 4241 23847180 SGTC_2363 9053361 176 µM -1.09704323728534 0.159028994344846 no 2888 0.136311245844931 4261 6469797 YMR079W SEC14 SGTC_2667 digitoxin 100 µM -1.10086037296215 0.158162932887491 no 2889 0.135478715513441 4125 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3204 9114183 49.47 µM -1.100912099792 0.158151217999826 no 2890 0.13546745769552 4175 17027248 SGTC_3174 9107204 49.47 µM -1.10137670532758 0.158046021507522 no 2891 0.135366369768157 4223 3938802 SGTC_1267 0828-0272 9.49 µM -1.10239789636865 0.157814963793347 no 2892 0.135144362842822 4283 745334 SGTC_2611 pyromycin 23.93 µM -1.10343934674712 0.157579550754256 no 2893 0.13491820880532 4161 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2913 7966556 36.57 µM -1.10403967696048 0.157443954931867 no 2894 0.134787963338742 4075 2976516 SGTC_1878 temozolomide 1 mM -1.10554295431968 0.157104748124016 no 2895 0.134462196315975 4127 5394 DNA alkylating agent. SGTC_3200 9114385 49.47 µM -1.10629915240222 0.156934297746192 no 2896 0.134298529272766 4214 17018030 YLR208W SEC13 SGTC_602 3130-1533 38.1 µM -1.10742167869564 0.156681499806216 no 2897 0.134055828685564 4253 720941 SGTC_1742 st038235 28.8875 µM -1.10937570434381 0.156242084239323 no 2898 0.133634069444691 4252 564103 YBR002C RER2 SGTC_1754 st042065 16.137 µM -1.10997946576766 0.156106476474246 no 2899 0.133503937561123 3995 1126236 YIL048W NEO1 SGTC_2296 7971656 126.45 µM -1.11020496046776 0.156055849161639 no 2900 0.133455357860438 4248 666570 SGTC_3018 9082602 49.47 µM -1.11086267589842 0.155908242917494 no 2901 0.13331373166617 4144 17332089 SGTC_458 nppb 133 µM -1.1123170664265 0.155582171606468 no 2902 0.133000924262462 4246 4549 A chloride channel blocker. SGTC_218 alverine citrate 93.75 µM -1.11304890688304 0.155418264758822 no 2903 0.132843712721614 4242 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3030 9087619 49.47 µM -1.11335618168749 0.155349479848197 no 2904 0.132777743124168 4233 25236973 SGTC_3100 9120536 49.47 µM -1.11345054583955 0.155328360021589 no 2905 0.132757488376931 4056 16421196 SGTC_1326 1431-2094 10.8 µM -1.11715215597746 0.154501390437071 no 2906 0.131964636646838 4194 616278 SGTC_2704 st078022 71.1 µM -1.12206741877072 0.153407787182856 no 2907 0.13091688780359 4264 54697681 SGTC_2161 5662504 8.5105 µM -1.1225295984644 0.153305220609431 no 2908 0.130818665014095 4171 2859334 SGTC_1727 st034309 9.9045 µM -1.12270985957198 0.153265229517383 no 2909 0.130780369592952 4283 870305 SGTC_265 mycophenolic acid 32.932 µM -1.12473485216157 0.15281645805616 no 2910 0.130350704150424 4286 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1202 1988-0068 29.6 µM -1.12721431042119 0.152268157478754 no 2911 0.129825940732691 4188 2850480 SGTC_818 4072-2707 53.5 µM -1.13043055541731 0.151558874076809 no 2912 0.129147422500492 4120 882871 SGTC_1678 st019265 80.2 µM -1.13089245776424 0.151457190710028 no 2913 0.129050179087596 4227 5367020 SGTC_2810 7959871 45.46 µM -1.13308303874132 0.15097557314228 no 2914 0.128589691700411 4193 2974535 SGTC_249 wiskostatin 11.211 µM -1.1355800464909 0.150427829491471 no 2915 0.128066181816369 4204 2775510 A n-wasp and actin depolymerizer. SGTC_525 k781-2675 26.7 µM -1.13614538162149 0.150304001607989 no 2916 0.127947862371707 4191 3651118 YDL195W SEC31 SGTC_1828 st055811 49 µM -1.13792706390128 0.149914196241894 no 2917 0.127575469606567 4231 5877589 SGTC_1552 6-methylflavone 10.6 µM -1.14012089551896 0.149435145727699 no 2918 0.127117968819803 4164 689013 SGTC_75 0159-0059 199.013 µM -1.14559109867515 0.148245113330494 no 2919 0.125982191034963 4318 5377270 SGTC_2187 6125751 200 µM -1.14960218742811 0.147376548331359 no 2920 0.125153878414039 4240 874498 SGTC_2063 5246145 200 µM -1.15084971884731 0.147107103351834 no 2921 0.124897033198535 4274 711240 SGTC_2619 obliquin 87.91 µM -1.15129938607247 0.147010064123122 no 2922 0.124804544823029 4200 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2834 9001755 58.44 µM -1.15546976151561 0.146112132825638 no 2923 0.123949054258842 4160 2989575 SGTC_2646 retinol 96.75 µM -1.15734524213972 0.145709523071468 no 2924 0.123565668149599 4248 445354 A vitamin A analog and teratogen. SGTC_1766 st045414 44.774 µM -1.15750532329765 0.145675192999394 no 2925 0.123532982839376 4257 253960 SGTC_2930 9013230 14.89 µM -1.15811467328932 0.145544565099844 no 2926 0.123408621385301 4269 2995857 SGTC_1128 3448-9350 235 µM -1.15867160756303 0.145425242607601 no 2927 0.123295034123295 4292 619386 SGTC_1607 st000305 50.6 µM -1.15909977636241 0.145333552711906 no 2928 0.123207758520938 4266 5457690 SGTC_1428 4049-0204 61.7 µM -1.1591086951059 0.14533164322765 no 2929 0.123205941033126 4292 X1428 SGTC_2843 9000894 45.46 µM -1.16092650564395 0.144942806073511 no 2930 0.122835894355802 4182 2242070 SGTC_328 k915-0120 63.5 µM -1.16394863266585 0.144297912072097 no 2931 0.12222241462577 4239 6624543 SGTC_2381 9035592 200 µM -1.16453928083803 0.144172099491604 no 2932 0.122102767115302 4251 4749657 SGTC_25 0118-0223 35.662 µM -1.16791207806051 0.143455085092423 no 2933 0.121421115850476 4266 5333628 SGTC_1054 3429-0080 167 µM -1.1695021416892 0.143117893927986 no 2934 0.121100689432962 4287 1162877 SGTC_41 0478-0632 82.643 µM -1.1701313972584 0.142984601082961 no 2935 0.120974047545411 4226 3750424 SGTC_1520 flindersine 88 µM -1.1720334835369 0.142582199431994 no 2936 0.120591806627205 4326 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1981 st071826 47 µM -1.17227097715355 0.142532009579599 no 2937 0.120544139986928 4292 11838600 SGTC_3139 9095020 49.47 µM -1.17324858359795 0.142325536495866 no 2938 0.120348067208079 4076 25236292 SGTC_3021 9087658 49.47 µM -1.17510000250629 0.141935066637011 no 2939 0.119977354834994 4258 25237042 SGTC_844 0330-0132 15.3 µM -1.17672414540123 0.141593127724726 no 2940 0.119652813661044 4302 2828079 SGTC_156 3474-0145 5.642 µM -1.17713848301756 0.141505984581978 no 2941 0.119570118676796 4127 2265471 SGTC_1277 0873-0036 22 µM -1.17743635117979 0.141443359656327 no 2942 0.119510693997467 4333 5965735 SGTC_2989 9073649 71.4286 µM -1.17802661332909 0.141319316210236 no 2943 0.119392998294019 4235 21367202 SGTC_2195 6536160 144.242 µM -1.18270339670156 0.140339098257738 no 2944 0.118463358779982 4238 3834386 SGTC_2786 7743617 45.45 µM -1.18317725480925 0.140240039461429 no 2945 0.118369452666594 4220 583674 SGTC_1499 4480-0877 67.3 µM -1.18698434345272 0.139445901196038 no 2946 0.117616898104891 4250 2861909 SGTC_2118 5526350 200 µM -1.18743160324605 0.13935280639333 no 2947 0.117528710210382 4310 743594 SGTC_1230 0170-0365 3.77 µM -1.19303758722102 0.13818953619339 no 2948 0.116427326386649 4331 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_996 3970-0799 1.8 µM -1.19323268457654 0.138149172068887 no 2949 0.116389128719885 4281 6615648 YGL040C HEM2 SGTC_2125 5246583 200 µM -1.19765121335393 0.137237165361468 no 2950 0.115526414789794 4307 835267 SGTC_2377 9073351 62.6 µM -1.19829753828544 0.137104106179692 no 2951 0.115400602310466 4253 7337946 YHR072W ERG7 SGTC_716 1683-5115 658 µM -1.20325973609421 0.136085472620584 no 2952 0.11443791247289 4270 723597 SGTC_2925 9010536 32.5 µM -1.2037249580645 0.135990238748468 no 2953 0.11434795120659 4214 2994177 SGTC_902 1120-0002 2.07 µM -1.20578403463249 0.135569280721936 no 2954 0.113950386485328 4268 3280475 SGTC_1350 1495-0454 146 µM -1.20683032080137 0.135355720210126 no 2955 0.113748748250466 4329 1069057 SGTC_205 1486-1330 71.903 µM -1.20988364097682 0.134733816948694 no 2956 0.113161772675784 4345 4118834 SGTC_164 4100-3994 89.624 µM -1.21193767920324 0.134316553270679 no 2957 0.112768118720835 4297 4615967 SGTC_2318 6029776 164 µM -1.21397479299183 0.133903605011255 no 2958 0.11237867498271 4342 818325 SGTC_2420 aureobasidin a 50 nM -1.21409820609098 0.133878615705083 no 2959 0.112355112483923 4395 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1007 4101-0031 70 µM -1.21681245587554 0.133329831064062 no 2960 0.111837789889193 4266 1146276 SGTC_506 n9-isopropylolomoucine 153 µM -1.21690406011237 0.133311336961292 no 2961 0.111820360340247 4300 6610355 SGTC_3335 9143315 29.6265 µM -1.21808804113307 0.13307246025991 no 2962 0.111595258941041 4300 4899691 SGTC_2854 9024559 71.43 µM -1.21848413501914 0.132992611273318 no 2963 0.111520025017289 4319 3163529 SGTC_3105 9121040 49.47 µM -1.21855142843119 0.132979048801524 no 2964 0.111507246939662 4201 41448907 SGTC_2139 5578692 56.4705 µM -1.21973345397995 0.132740975848598 no 2965 0.111282967637066 4274 650991 YMR113W FOL3 SGTC_2623 humulene 100 µM -1.21993943382447 0.13269951929411 no 2966 0.11124391777615 4304 6187145 An anti-inflammatory. SGTC_2649 anisomycin 9.56 µM -1.22064048270599 0.132558489450271 no 2967 0.111111085758942 4347 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.22593991803907 0.131495743975698 no 2968 0.110110642796363 4206 17037758 SGTC_3303 9125618 40.5795 µM -1.22682039886077 0.131319744271556 no 2969 0.109945051036223 4317 22695467 SGTC_2015 5119600 184 µM -1.22989926844691 0.130705586888347 no 2970 0.109367414108582 4339 2828786 SGTC_247 mechlorethamine 29.705 µM -1.23113829155033 0.130458994012605 no 2971 0.10913557310809 4240 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2217 6934799 96.0675 µM -1.2318834167261 0.130310852727732 no 2972 0.108996318466331 4282 675606 SGTC_558 k064-0027 21.3 µM -1.23376833076592 0.129936625194867 no 2973 0.108644621742959 4318 5088526 SGTC_1720 st037298 9.481 µM -1.23416607109795 0.129857753680438 no 2974 0.108570513756645 4303 597396 SGTC_2380 9035439 200 µM -1.23670630867108 0.129354808990862 no 2975 0.108098067873649 4399 6462575 SGTC_1509 1326-1131 80 µM -1.23706777737093 0.129283351230973 no 2976 0.10803096061969 4279 768313 SGTC_3162 9099653 49.47 µM -1.23842189098856 0.129015903457467 no 2977 0.107779833884519 4293 25237511 SGTC_411 enrofloxacin 100 µM -1.23899388467366 0.128903045679241 no 2978 0.107673881392021 4380 71188 A bacterial gyrase inhibitor. SGTC_330 1488-0319 80.1 µM -1.24231793333785 0.128248546235569 no 2979 0.107059640631812 4362 6846614 SGTC_1339 1486-1321 22.7 µM -1.24503044207924 0.127716170583943 no 2980 0.10656028021546 4351 3469382 SGTC_1060 3448-7350 82 µM -1.24973316125764 0.126796826742942 no 2981 0.105698519647636 4249 570178 SGTC_2330 7979373 200 µM -1.25050377765351 0.126646617910113 no 2982 0.105557788108801 4247 1863007 SGTC_1924 st058459 75.1 µM -1.25123714823297 0.12650378417479 no 2983 0.105423984360505 4271 688683 SGTC_214 4373-3496 70 µM -1.25184625309872 0.126385238187741 no 2984 0.105312946235869 4427 3779166 SGTC_2439 5492030 7.2 µM -1.25409417568161 0.125948410168214 no 2985 0.104903888553034 4327 5722370 SGTC_3289 9119912 71.43 µM -1.25579957789087 0.125617710654601 no 2986 0.104594322351853 4351 17014829 SGTC_570 0987-0065 62.6 µM -1.25756246366141 0.125276501671629 no 2987 0.104275017806352 4159 3104428 SGTC_2010 4012422 159 µM -1.25838105478922 0.125118282417587 no 2988 0.104126990059443 4272 952393 SGTC_3128 9127691 49.47 µM -1.2584482076846 0.125105309141523 no 2989 0.104114853409265 4358 41316314 SGTC_2817 7995342 71.43 µM -1.25934788873723 0.124931590251507 no 2990 0.103952351515902 4328 18879975 SGTC_174 3553-0389 74.3 µM -1.26348321504607 0.124135270277667 no 2991 0.103207787518286 4396 738071 SGTC_3324 9138759 60.749 µM -1.26365093416901 0.124103048513427 no 2992 0.103177671678128 4367 45595710 SGTC_3096 9117468 49.47 µM -1.2655915065315 0.123730656288102 no 2993 0.102829684238499 4251 41316311 SGTC_471 1-acyl-paf 4 µM -1.26678518963695 0.123501979723466 no 2994 0.102616054592604 4291 16759367 SGTC_3157 9099274 49.47 µM -1.26829131202365 0.123213871068201 no 2995 0.102346969250386 4363 17217662 SGTC_2866 9034245 58.44 µM -1.2710330958178 0.122690600544157 no 2996 0.101858437429284 4345 6462273 SGTC_1340 1486-1359 257 µM -1.27154781396573 0.122592540423401 no 2997 0.101766914344928 4276 4309068 SGTC_935 2996-0153 430 µM -1.27190355171883 0.12252480015914 no 2998 0.101703694884327 4344 23738523 SGTC_129 0088-0017 176.636 µM -1.27465524769614 0.122001704176624 no 2999 0.101215646686252 4218 182446 SGTC_3203 9113543 49.47 µM -1.27492930182617 0.121949692641637 no 3000 0.101167133315839 4382 17018012 SGTC_542 3381-0244 89.3 µM -1.27557599034803 0.121827022196401 no 3001 0.101052722961873 4367 1112843 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.27619573630767 0.121709543862183 no 3002 0.100943167736844 4340 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_513 4245-1575 41.7 µM -1.27627346535318 0.121694815253341 no 3003 0.100929433344291 4192 719745 SGTC_3107 9121808 49.47 µM -1.27735822896978 0.121489397835175 no 3004 0.100737902373815 4295 662681 SGTC_991 3996-0057 64.7 µM -1.28135587766472 0.120734483600795 no 3005 0.100034347202965 4392 715343 SGTC_1881 5652484 16 µM -1.28175424972632 0.120659436514352 no 3006 0.0999644338837962 4334 2255129 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.28465813316839 0.120113382277776 no 3007 0.099455887276758 4355 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3235 9132602 49.47 µM -1.28477053083084 0.120092281775982 no 3008 0.0994362415636846 4349 4912240 SGTC_3252 9135871 49.47 µM -1.28738977038715 0.119601309447692 no 3009 0.0989792340254565 4372 17682838 SGTC_1392 3455-1037 33.9 µM -1.28785338574381 0.119514553171152 no 3010 0.098898502266262 4341 981132 SGTC_176 1486-1328 72.834 µM -1.28878896039628 0.119339614431935 no 3011 0.098735732502435 4403 22310231 SGTC_1495 4469-0029 237 µM -1.29038329980819 0.119041912848036 no 3012 0.098458803791681 4364 793680 SGTC_2143 5623677 140.463 µM -1.29630735025691 0.117940344981697 no 3013 0.097434808633789 4295 5375313 SGTC_545 4218-0007 221 µM -1.30510450475687 0.116317865715823 no 3014 0.0959286325265005 4357 2840508 SGTC_1103 duloxetine 36.1 µM -1.30516146719326 0.116307411864273 no 3015 0.0959189360026897 4445 60835 A selective serotonin reuptake inhibitor. SGTC_725 1497-0963 19 µM -1.30735310423599 0.115905704706056 no 3016 0.0955464082229297 4472 3549977 SGTC_1435 4092-0789 56.7 µM -1.31216469224717 0.115027242258592 no 3017 0.0947322860635672 4364 2248285 SGTC_1946 st076057 65.1 µM -1.31599695280287 0.114330972949488 no 3018 0.0940875327145953 4335 953009 SGTC_2771 fluoxetine 41.05 µM -1.32084458897262 0.113454529642991 no 3019 0.0932765943900958 4387 3386 A selective serotonin reuptake inhibitor. SGTC_2916 7875993 68.79 µM -1.32249399068151 0.113157416273937 no 3020 0.0930018545548889 4248 1299250 SGTC_2953 9074162 66.49 µM -1.32416446162285 0.112857073892078 no 3021 0.0927242153906586 4367 16451992 SGTC_1282 0886-0010 32.4 µM -1.3242730183813 0.112837575637655 no 3022 0.0927061940438864 4399 2836211 YNL267W PIK1 SGTC_387 norethindrone acetate 66.7 µM -1.32519647600387 0.112671807464361 no 3023 0.0925529969436534 4393 541197 SGTC_1338 1486-1223 76 µM -1.32739265745527 0.112278273777297 no 3024 0.0921894136523151 4400 3444526 SGTC_1480 1070-0044 41.2 µM -1.32847107778447 0.112085391669142 no 3025 0.0920112660251757 4417 3124987 SGTC_1472 k841-0093 193 µM -1.33211140213853 0.111436046920204 no 3026 0.0914117920485016 4503 X1472 SGTC_11 0438-0307 1.3 µM -1.3367181590147 0.110618179516438 no 3027 0.0906573261010148 4374 4011476 SGTC_2430 5571206 200 µM -1.33788105716743 0.110412404476844 no 3028 0.0904676065439911 4380 1731771 SGTC_2745 rifampicin 24.3 µM -1.33995067388368 0.110046864576019 no 3029 0.0901306909390081 4476 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2324 6149169 200 µM -1.34201899633173 0.109682421522021 no 3030 0.0897949181892225 4318 2888231 SGTC_2576 guaiol 23.12 µM -1.34319246948381 0.10947603858063 no 3031 0.0896048297235966 4292 227829 SGTC_3076 9116187 49.47 µM -1.34525952499609 0.109113176698451 no 3032 0.0892707197301706 4383 27241210 SGTC_2965 9082772 38.63 µM -1.3456405797324 0.1090463787926 no 3033 0.0892092289910759 4401 16459634 SGTC_148 3253-0744 288.01 µM -1.34652254915953 0.108891884592234 no 3034 0.0890670266335283 4270 6893655 SGTC_548 1436-0017 110 µM -1.34810511668739 0.10861506155484 no 3035 0.0888122879894392 4433 9677137 SGTC_2658 polymyxin b sulfate 77.05 µM -1.35055867682354 0.108186885621309 no 3036 0.0884184227753968 4426 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3338 9144300 39.5675 µM -1.35159719633363 0.108006017848353 no 3037 0.0882521038573176 4401 4901274 SGTC_10 0279-0212 42.575 µM -1.35226339987022 0.107890107036019 no 3038 0.0881455341871783 4400 39851 YBR002C RER2 SGTC_375 3970-0961 9.27 µM -1.35248823778196 0.107851008369647 no 3039 0.088109589508929 4365 2898222 SGTC_1394 3474-0001 65.7 µM -1.3549903168591 0.107416592561141 no 3040 0.087710321072134 4372 5017666 YIL048W NEO1 SGTC_2101 5377231 179.231 µM -1.35577718497919 0.107280236040628 no 3041 0.0875850362661191 4436 2844213 SGTC_2879 9041815 71.43 µM -1.35685659723936 0.107093387570184 no 3042 0.0874133900077846 4432 4942971 SGTC_865 0488-0499 301 µM -1.36379893720154 0.105897261552288 no 3043 0.0863154274461688 4359 9634651 SGTC_2620 irigenin 100 µM -1.36841494496909 0.105107312036246 no 3044 0.0855911144315756 4410 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1874 staurosporine 7.6 µM -1.36860593431725 0.105074719653489 no 3045 0.0855612440109472 4419 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1713 st033146 12.748 µM -1.37079081234675 0.104702390012535 no 3046 0.0852200879230477 4407 674619 SGTC_278 4092-0821 23.9 µM -1.37234613347126 0.104437927303786 no 3047 0.0849778552236502 4414 877900 SGTC_2491 paeonol 100 µM -1.37567211574425 0.103874010967068 no 3048 0.0844615843024882 4380 11092 Increases levels of cortical cytochrome oxidase. SGTC_1897 st060201 15 µM -1.37734768539442 0.103590758107262 no 3049 0.0842023894009287 4433 611878 SGTC_1059 3448-6867 171 µM -1.37815655654744 0.103454220269514 no 3050 0.0840774785019112 4390 3934407 SGTC_1423 4048-0112 5.59 µM -1.3804136125751 0.103073919008906 no 3051 0.0837296656384153 4478 X1423 SGTC_2442 5158906 48.48 µM -1.38341794877411 0.102569281964725 no 3052 0.0832683750812914 4436 1893835 SGTC_2376 9072922 81.32 µM -1.38385105362922 0.102496681908306 no 3053 0.0832020333509726 4417 17087968 SGTC_1646 st011709 75.6 µM -1.3846533540941 0.102362293430428 no 3054 0.0830792443317609 4387 5757843 SGTC_1895 st058434 18.3 µM -1.38471604175236 0.102351798401288 no 3055 0.0830696559685189 4421 5393175 SGTC_2407 paclitaxel 400 µM -1.38800450678517 0.101802347580559 no 3056 0.0825678363865083 4470 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_244 nsc-207895 1.295 µM -1.38847275087635 0.10172428631287 no 3057 0.08249656834849 4196 42640 SGTC_515 4092-1064 102 µM -1.38981121088105 0.101501391136552 no 3058 0.0822931064418298 4411 717353 SGTC_1843 st055809 45.5 µM -1.39047102340062 0.101391642841516 no 3059 0.0821929462267881 4469 16413835 SGTC_1583 clindamycin 39.6 µM -1.39256788376688 0.101043440633587 no 3060 0.0818752502477297 4385 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1994 st072947 40.9 µM -1.39291961326848 0.100985118308161 no 3061 0.0818220503584077 4475 5286565 YDL195W SEC31 SGTC_2740 felodipine 17.08 µM -1.40557184342995 0.098903467610801 no 3062 0.0799256509338308 4493 3333 L-type calcium channel blocker SGTC_2379 9035213 200 µM -1.40765025068615 0.0985645347298161 no 3063 0.0796173299297671 4444 646551 SGTC_231 b-estradiol 524 µM -1.41001658374957 0.0981796848606602 no 3064 0.0792673930820396 4424 450 A steroid. SGTC_1487 3970-0795 2.82 µM -1.41118440094156 0.0979901624583067 no 3065 0.0790951242409808 4491 3765103 SGTC_70 0141-0289 43.283 µM -1.41137471704822 0.0979593019117124 no 3066 0.0790670769266822 4397 352408 SGTC_250 brefeldin a 552.239 µM -1.42143917731171 0.0963374401706055 no 3067 0.077594561922518 4358 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3124 9127567 49.47 µM -1.42396287044972 0.0959338657780112 no 3068 0.0772286102525179 4408 17592030 SGTC_1432 4049-0298 68.4 µM -1.42453178934711 0.0958430595493776 no 3069 0.0771462947759266 4463 741646 SGTC_2331 7980721 200 µM -1.42499285502463 0.095769514371663 no 3070 0.0770796332383274 4412 2981221 SGTC_1379 2144-0755 36.5 µM -1.42727523848866 0.095406059824734 no 3071 0.076750287496356 4495 5392327 SGTC_1996 st072960 66.8 µM -1.42777040861797 0.0953273414534405 no 3072 0.0766789763838708 4485 1719405 SGTC_676 falcarinol 140 µM -1.42872556911513 0.0951756324182437 no 3073 0.07654156286938 4469 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1926 methyl fluorone black 53.6 µM -1.42887746652737 0.0951515228049358 no 3074 0.0765197275251335 4087 72721 Reacts with homocysteine. SGTC_1796 st049173 110.4 µM -1.43565226078507 0.094080776106103 no 3075 0.0755506579259923 4450 94134 SGTC_2489 cantharidin 73.42 µM -1.43662776022903 0.093927334900057 no 3076 0.0754118956763985 4417 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1711 st032263 62.8 µM -1.44042635993019 0.0933315938222566 no 3077 0.0748734051862577 4440 3958979 SGTC_2175 5807670 165.306 µM -1.44402772237974 0.0927693680255748 no 3078 0.0743655886961434 4422 241186 SGTC_2608 thymoquinone 42.66 µM -1.44449172286316 0.092697113226548 no 3079 0.0743003531832187 4422 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2772 vinpocetine 57.06 µM -1.44456214514085 0.0926861506106577 no 3080 0.0742904560801694 4465 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1774 st048371 48.465 µM -1.44516340338478 0.0925925919512996 no 3081 0.0742059966082027 4460 4242727 SGTC_2308 7584454 197.62 µM -1.44724068027049 0.0922698953372449 no 3082 0.0739147633223679 4455 893577 SGTC_104 0074-0074 590.992 µM -1.45026614015809 0.0918013924377199 no 3083 0.0734921586962312 4318 3943124 SGTC_2885 9057732 51.95 µM -1.45259925952444 0.0914413059913418 no 3084 0.0731675258915817 4487 6471414 SGTC_1875 nocodazole 6 µM -1.45333114818884 0.0913285645492289 no 3085 0.073065916501355 4497 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_753 1322-0200 289 µM -1.45950917475115 0.0903809938277975 no 3086 0.0722125086426534 4522 5403907 SGTC_408 cantharidin 100 µM -1.46281216287455 0.0898773941210191 no 3087 0.0717593920087302 4455 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2078 5212016 200 µM -1.46403585456995 0.0896913508164999 no 3088 0.0715920760201297 4380 1899708 SGTC_1140 3229-1848 2.98 µM -1.46460427332172 0.0896050290298938 no 3089 0.0715144577186274 4458 2849525 SGTC_1138 3761-0006 1.03 µM -1.46836476828903 0.0890355046108996 no 3090 0.0710025831623135 4508 12061087 SGTC_108 0509-0257 621.132 µM -1.46838711544151 0.0890321282218444 no 3091 0.0709995497249475 4434 536624 SGTC_2708 st078559 56 µM -1.4693847530959 0.0888814941108804 no 3092 0.0708642302167574 4432 17250902 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.47027668873544 0.0887469807606678 no 3093 0.0707434159587756 4500 4174840 SGTC_213 1246-0773 967 nM -1.47137977524882 0.0885808333725403 no 3094 0.0705942199207617 4514 6251622 SGTC_934 2950-0684 338 µM -1.47342504468323 0.0882733872359165 no 3095 0.0703182306324498 4487 1121253 SGTC_3111 9122088 49.47 µM -1.47521167045396 0.0880054719807696 no 3096 0.0700778224139686 4407 16876704 SGTC_1102 cgs 12066b 26.1 µM -1.47643076080385 0.0878230103814282 no 3097 0.0699141449752015 4487 6438352 A 5-HT1B full agonist. SGTC_444 curcumin 90.4 µM -1.47683741892029 0.08776220854917 no 3098 0.0698596117484568 4400 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1189 1431-2119 7.28 µM -1.47940101562575 0.087379632980601 no 3099 0.0695165844279851 4465 3107275 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.48319374884165 0.0868159138509881 no 3100 0.0690114707956011 4490 7104 SGTC_2024 5144227 134 µM -1.48923759192492 0.0859232311578566 no 3101 0.0682124075026365 4457 3475211 SGTC_653 0203-0016 55.2 µM -1.4967146544531 0.0848283879059089 no 3102 0.0672337607418116 4565 295302 SGTC_131 0141-0277 33.849 µM -1.496866844172 0.084806212360563 no 3103 0.0672139544810546 4447 1547771 SGTC_3261 9137475 49.47 µM -1.4975764484639 0.0847028733852403 no 3104 0.067121664771788 4506 17027690 SGTC_2919 7978188 46.38 µM -1.49781368764657 0.0846683455482506 no 3105 0.0670908317869541 4495 2980291 SGTC_3060 1327-0027 12.5 µM -1.51230729184066 0.0825789089958477 no 3106 0.0652278534495773 4414 16000455 YPR107C YTH1 SGTC_2986 9022445 71.43 µM -1.51421498047137 0.0823068074396875 no 3107 0.0649856617216743 4478 6459286 SGTC_3160 9100216 49.47 µM -1.515042445256 0.0821889928669964 no 3108 0.0648808277386524 4488 17191039 SGTC_3013 9080133 71.4286 µM -1.5182618352906 0.0817318239066121 no 3109 0.0644742023415589 4555 17050193 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.52191866649068 0.0812148644984498 no 3110 0.0640147306785493 4579 688801 SGTC_3039 9090270 49.47 µM -1.52355814280485 0.0809838973557976 no 3111 0.0638095629896927 4510 17173750 SGTC_995 3931-2021 34.6 µM -1.52642476746306 0.0805812431035967 no 3112 0.0634520566873485 4522 730143 SGTC_325 2810-4341 181 µM -1.53876357439144 0.0788653473791798 no 3113 0.0619310127388168 4512 774970 SGTC_1888 azatryptophan 97.5 µM -1.54617645683063 0.0778478694757161 no 3114 0.061030978877844 4532 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1867 st057372 64 µM -1.54673183097305 0.0777720429188341 no 3115 0.0609639620806616 4495 688837 SGTC_134 0269-0018 6.916 µM -1.54688233048682 0.0777515045184304 no 3116 0.0609458112695496 4457 4378915 SGTC_1444 4112-3581 28 µM -1.54892257756058 0.0774734817083628 no 3117 0.0607001663935567 4599 2877249 SGTC_702 1488-0190 94 µM -1.55332198445882 0.0768765481538728 no 3118 0.0601731153238608 4562 949357 SGTC_1 0258-0098 57.368 µM -1.55815124478381 0.0762253226499859 no 3119 0.0595986996911831 4440 6790032 YDR047W HEM12 SGTC_385 1494-0393 12.4 µM -1.56010736340622 0.0759627381140246 no 3120 0.0593672558874406 4497 3090647 SGTC_326 k292-0812 17.5 µM -1.5627793205094 0.0756051748699978 no 3121 0.0590522549169174 4526 3579357 SGTC_84 0443-0269 128.823 µM -1.56707739100132 0.0750326963883373 no 3122 0.0585483015786568 4475 6150058 SGTC_1620 st003704 16.5 µM -1.56980885638248 0.0746706025776639 no 3123 0.0582297932837398 4535 2834414 SGTC_2831 7999036 19.48 µM -1.56986060289594 0.0746637557495377 no 3124 0.0582237724365118 4503 2988270 SGTC_1784 st039334 36.3 µM -1.57013981011774 0.0746268207762871 no 3125 0.0581912943570419 4533 3496984 SGTC_705 1124-0212 310 µM -1.57232923229286 0.0743376759438276 no 3126 0.0579371084947167 4523 9554485 SGTC_774 k060-0086 136 µM -1.57479503673057 0.0740130559581614 no 3127 0.057651881218663 4527 5911235 SGTC_61 0978-8327 98.565 µM -1.5762554776197 0.0738213021323772 no 3128 0.0574834688868364 4457 6150059 YHR072W ERG7 SGTC_2585 alliin 100 µM -1.57757322777981 0.0736486094640051 no 3129 0.0573318434461449 4565 87310 A garlic compound which reacts with lipids. SGTC_2567 aureobasidin a 60 nM -1.57773919183836 0.0736268816005108 no 3130 0.0573127693124475 4589 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1201 1889-3372 45.9 µM -1.58413499670243 0.0727932769418376 no 3131 0.0565815009284387 4446 5392199 SGTC_2669 eugenol 100 µM -1.59004850390743 0.0720289803849978 no 3132 0.0559119361358589 4566 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2929 9013348 24.6 µM -1.59020470996312 0.0720088751186965 no 3133 0.0558943346000373 4506 2995952 SGTC_2411 st077133 39.94 µM -1.5911346841601 0.0718892672790251 no 3134 0.0557896341600808 4508 1403142 YNL221C POP1 SGTC_2065 5221596 34.26 µM -1.59202458923994 0.0717749555982731 no 3135 0.0556895898235958 4506 788581 SGTC_1307 1187-1599 12.2 µM -1.59336984798371 0.071602416759129 no 3136 0.0555386228619749 4560 1538471 SGTC_3356 9151811 4.48 µM -1.59455816662222 0.0714502714469367 no 3137 0.0554055368524512 4565 1859254 YPR165W RHO1 SGTC_508 roscovitine 141 µM -1.59700556827489 0.0711377024095632 no 3138 0.055132233008072 4604 160355 A CDKinase inhibitor. SGTC_1690 st023502 41.2 µM -1.59902017803794 0.0708811959906512 no 3139 0.0549080595882865 4558 24207482 SGTC_604 1000-0114 314 µM -1.60134295483426 0.0705863353139465 no 3140 0.0546504899975806 4548 1572745 SGTC_1415 3966-0071 78.1 µM -1.60488211277299 0.0701388771506744 no 3141 0.0542598753587434 4464 2893185 SGTC_279 1273-0055 2.93 µM -1.60547097972234 0.070064638483496 no 3142 0.0541950973688869 4590 2847562 SGTC_1004 4084-0029 199 µM -1.61204324591916 0.069240167778219 no 3143 0.0534762647137049 4549 716894 YLR208W SEC13 SGTC_3224 9130643 49.47 µM -1.61295527294939 0.0691263498022799 no 3144 0.0533771126945454 4555 17644395 SGTC_1997 st073024 93.8 µM -1.61949566123781 0.0683143505229457 no 3145 0.0526703296337926 4592 686268 SGTC_1172 0370-0043 85 µM -1.62286495450659 0.0678989301681385 no 3146 0.0523091383353851 4574 376585 SGTC_527 4476-4215 268 µM -1.62438964849535 0.0677115838454215 no 3147 0.0521463374610792 4544 4418754 SGTC_3044 9093193 49.47 µM -1.6284149530228 0.0672188944619557 no 3148 0.0517184645556584 4555 25236277 SGTC_150 3970-0969 77.2 µM -1.62941904434177 0.0670964286388889 no 3149 0.0516121699547243 4577 6615640 SGTC_1100 amiodarone 5.07 µM -1.63055695221288 0.066957850286332 no 3150 0.0514919193697676 4589 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2076 5212012 200 µM -1.63503095189005 0.0664151367532673 no 3151 0.0510212796471122 4551 604802 SGTC_2976 9009005 19.48 µM -1.63530401071677 0.0663821242580164 no 3152 0.0509926666121897 4533 2993148 SGTC_510 ag-490 170 µM -1.64165141890152 0.065618305165281 no 3153 0.0503311325116722 4681 5328779 SGTC_3278 9139605 49.47 µM -1.64181862826204 0.065598276438366 no 3154 0.0503137986621786 4544 7958859 SGTC_3186 9110464 49.47 µM -1.65129357355148 0.0644710712962336 no 3155 0.049339321945095 4562 17018021 SGTC_2968 9090663 33.37 µM -1.65719038762098 0.0637771791349825 no 3156 0.0487404946626324 4517 25236811 SGTC_389 tpck 16.7 µM -1.66227007449836 0.0631841100980941 no 3157 0.0482293175993105 4604 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3 0833-0587 95.581 µM -1.66266098238816 0.0631386489546236 no 3158 0.0481901583120158 4468 5382644 SGTC_726 3448-4391 34.2 µM -1.67168920226734 0.0620957724016423 no 3159 0.0472928122304005 4639 1356692 SGTC_1811 st050069 61.5 µM -1.6763993727642 0.0615570471907752 no 3160 0.0468299958541069 4585 3877702 SGTC_2176 5809774 33.9695 µM -1.68361468041215 0.0607388838553903 no 3161 0.0461280798633176 4511 2870539 SGTC_66 0109-0187 42.4 µM -1.69495160994618 0.0594705677910799 no 3162 0.0450423004105215 4437 759417 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.69648822772336 0.0593002684348506 no 3163 0.0448967288688255 4567 97141 SGTC_505 gw-5074 63.9 µM -1.69809700997875 0.0591223812551182 no 3164 0.0447447269170637 4583 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_1790 st045711 43.5 µM -1.70837154406969 0.0579961535005996 no 3165 0.0437837119131699 4580 585119 SGTC_2277 7947813 106.88 µM -1.71205131261801 0.0575969265884858 no 3166 0.0434436063250616 4601 1246798 SGTC_1216 1165-0504 9.65 µM -1.71447569795953 0.0573350824890536 no 3167 0.043220698281591 4630 6304004 SGTC_1348 1493-0373 93.8 µM -1.72145360653814 0.0565866638888113 no 3168 0.0425842719490922 4607 3010129 SGTC_520 3584-0023 682 µM -1.72155513177114 0.0565758318427603 no 3169 0.0425750684827468 4575 1340790 SGTC_1808 st050063 61.5 µM -1.72626387517956 0.0560752339362779 no 3170 0.0421499756140865 4552 4011993 SGTC_1799 st045822 46.1415 µM -1.72664713407449 0.0560346429771674 no 3171 0.0421155277187992 4582 3674992 SGTC_219 mitoxanthrone 164.414 µM -1.72820341622379 0.0558700551557425 no 3172 0.0419758807418821 4566 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_585 0kpi-0023 191 µM -1.73278792134299 0.0553874273495842 no 3173 0.0415666852456126 4541 64601 SGTC_1658 st012944 20 µM -1.73386700035686 0.0552743087168452 no 3174 0.0414708421233072 4450 24207260 SGTC_3341 9147222 25.867 µM -1.73602273842931 0.0550488715438029 no 3175 0.0412799070494125 4600 1939759 SGTC_2523 spermine 47.74 µM -1.73713624316705 0.0549327112052406 no 3176 0.0411815626941793 4596 1103 A DNA binding polyamine. SGTC_546 peri-Naphthalide 147 µM -1.73714868586455 0.0549314142835711 no 3177 0.0411804648335539 4570 223824 A penicillin ester. SGTC_1041 0206-0046 107 µM -1.73869510276292 0.0547704171494914 no 3178 0.0410442039556568 4611 50494 SGTC_1732 st034308 51.822 µM -1.75455348538385 0.0531408494566086 no 3179 0.0396678568356614 4499 830119 SGTC_464 bw-b 70c 158 µM -1.7578115131292 0.0528108710289078 no 3180 0.0393897928619637 4601 5353454 SGTC_2167 5876490 200 µM -1.75854143903865 0.0527371662770295 no 3181 0.0393277135813484 4614 686534 SGTC_1553 gossypol 38.6 µM -1.75964082020398 0.0526263095994548 no 3182 0.0392343628695862 4581 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2412 st077135 33.4 µM -1.76293074798406 0.0522956724629752 no 3183 0.0389560851794909 4611 13258915 SGTC_284 0988-0104 32.6 µM -1.76713690566515 0.0518753593852105 no 3184 0.0386026515672731 4596 4666532 SGTC_1762 st045503 25.4615 µM -1.76736188777267 0.0518529532227426 no 3185 0.0385838207050201 4634 4645554 SGTC_1548 st061468 90.8 µM -1.76851134191433 0.0517385980930521 no 3186 0.0384877288943102 4662 390799 SGTC_507 nimesulide 162 µM -1.77087065281156 0.0515045066429701 no 3187 0.0382911067749515 4633 4495 A COX2 inhibitor. SGTC_940 3232-1287 54.8 µM -1.77144977815537 0.051447174611573 no 3188 0.0382429685682651 4602 1585493 YIL048W NEO1 SGTC_2223 6903751 107.57 µM -1.77237779841803 0.051355408658368 no 3189 0.038165932334903 4600 5598863 SGTC_3181 9108277 49.47 µM -1.77272077290485 0.0513215270871342 no 3190 0.0381374936018974 4604 17097298 SGTC_904 1141-0088 396 µM -1.77284778711508 0.0513089841914046 no 3191 0.0381269662334141 4637 1378119 SGTC_2201 6605497 169.863 µM -1.7831811584056 0.0502966873400026 no 3192 0.0372784092687716 4599 670741 SGTC_3246 9135460 32.98 µM -1.79765483366701 0.0489056239087075 no 3193 0.0361158615358005 4624 41446951 SGTC_2426 5582046 32.21 µM -1.80593866196269 0.0481234039951261 no 3194 0.0354639605912654 4600 2251934 SGTC_3237 9133362 49.47 µM -1.80615880849562 0.048102753512154 no 3195 0.0354467685108341 4617 43845137 SGTC_1261 0712-0010 12.7 µM -1.80738132287872 0.0479882065592679 no 3196 0.0353514220170537 4616 2840123 SGTC_697 0508-1955 564 µM -1.81847330781816 0.0469588603221583 no 3197 0.0344959113922292 4641 6243113 SGTC_564 3555-0129 330 µM -1.81898936368189 0.0469114043141675 no 3198 0.0344565264061682 4577 563260 SGTC_3295 9122362 53.5725 µM -1.81921739636527 0.0468904469013802 no 3199 0.0344391349008823 4617 4730473 SGTC_2443 5493264 126.67 µM -1.82452710637035 0.0464045760453655 no 3200 0.0340362111094938 4645 5340055 SGTC_105 0111-0055 734.78 µM -1.82767517882204 0.0461184219582353 no 3201 0.033799157725718 4631 5179370 SGTC_2910 7948405 25.97 µM -1.8287454615664 0.0460214586528885 no 3202 0.0337188742971396 4614 2971328 SGTC_971 1315-0384 26.7 µM -1.83034096046461 0.0458772169945557 no 3203 0.0335994850319741 4656 6769120 SGTC_1854 st056233 32.9 µM -1.83217414315746 0.0457119361733605 no 3204 0.0334627399335329 4575 5393174 SGTC_2032 5185112 25.99 µM -1.83242089286636 0.0456897256695837 no 3205 0.0334443688317617 4523 5718189 SGTC_2870 9038528 12.99 µM -1.8355426052152 0.0454094816596979 no 3206 0.0332126661840781 4647 6463316 SGTC_1578 josamycin 24.2 µM -1.83915856573541 0.04508659764292 no 3207 0.0329459334989593 4631 5282165 A P450 substrate. SGTC_1689 st020265 53.493 µM -1.83930040019745 0.0450739704142191 no 3208 0.0329355071147104 4624 5758320 YPR016C TIF6 SGTC_3315 9136395 68.55 µM -1.84568434259695 0.044508561983033 no 3209 0.0324690259794837 4645 16876844 SGTC_2246 7293507 91.5585 µM -1.85301614543894 0.0438662685846813 no 3210 0.0319400222704087 4660 887656 SGTC_1311 1190-0148 100 µM -1.85670934840526 0.0435455732620988 no 3211 0.031676258387001 4660 1961333 SGTC_1106 tegaserod maleate 11.7 µM -1.85992504068023 0.0432678856180849 no 3212 0.0314480660021982 4659 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2396 5342950 42.78 µM -1.8600719777036 0.0432552312722839 no 3213 0.0314376715905056 4614 1886677 SGTC_2124 5246320 200 µM -1.86150939674465 0.0431315970429832 no 3214 0.0313361374461221 4623 579342 SGTC_619 1652-1634 108 µM -1.8650120056268 0.0428315282007302 no 3215 0.0310898607032352 4629 5400454 SGTC_3064 1327-0027 10 µM -1.86913892122361 0.0424801424653487 no 3216 0.030801744634335 4638 16000455 YPR107C YTH1 SGTC_2840 9008771 71.43 µM -1.87002743380465 0.0424047960084109 no 3217 0.0307400041584203 4616 2992978 SGTC_2084 5306078 60.6385 µM -1.88669077388932 0.0410116513283983 no 3218 0.029600964665913 4611 679340 SGTC_1626 st003712 1.76 µM -1.8878184947474 0.0409187249679539 no 3219 0.0295251607077071 4642 24207035 SGTC_1488 4013-0813 75.9 µM -1.89070235758638 0.0406818658458457 no 3220 0.0293320437862445 4686 2910057 SGTC_2096 5468907 200 µM -1.89238046626395 0.0405445513388224 no 3221 0.0292201533702358 4670 759785 SGTC_1687 st020778 55.3625 µM -1.89283034443392 0.0405078032046926 no 3222 0.02919021740252 4685 4259299 SGTC_2336 9001819 198.65 µM -1.89290365159502 0.0405018176988183 no 3223 0.0291853417837126 4633 2989602 SGTC_1120 ficusin 1.78878 µM -1.89436506225259 0.040382643755936 no 3224 0.0290882852519823 4633 6199 A DNA cross-linker. SGTC_1635 st007035 42.4 µM -1.8960034899426 0.0402493733071127 no 3225 0.0289797915232241 4615 3716403 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.89981275847357 0.039940906220902 no 3226 0.0287288480069334 4635 756377 SGTC_212 3807-4682 38.772 µM -1.90104343790803 0.039841659836952 no 3227 0.0286481616231243 4714 3125501 YBL034C STU1 SGTC_790 1575-0012 79.1 µM -1.91086007491898 0.0390571686582012 no 3228 0.0280112825062902 4675 378741 YLR208W SEC13 SGTC_2918 7977171 22.06 µM -1.91334080850847 0.0388609255109892 no 3229 0.0278522183378494 4647 2236483 SGTC_3262 9137218 49.47 µM -1.91769548079576 0.0385183834522969 no 3230 0.0275748175546409 4677 17650664 SGTC_866 0495-0101 262 µM -1.92584974849411 0.0378835815318 no 3231 0.0270615687893369 4660 635694 SGTC_1116 jasmonic acid  1.58368 µM -1.93209118412705 0.0374034814412745 no 3232 0.0266741261316893 4698 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2954 9074818 52.69 µM -1.93291865540121 0.0373402059172405 no 3233 0.0266231096727481 4655 16648742 SGTC_2475 5812728 15.03 µM -1.93305307006338 0.0373299356840997 no 3234 0.0266148302453455 4629 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1460 k062-0059 9.15 µM -1.93518780487567 0.0371671359296927 no 3235 0.0264836268491056 4555 1373085 SGTC_2093 5331342 194.4 µM -1.93649036356661 0.0370680851531692 no 3236 0.0264038358253502 4678 33839 SGTC_1093 fluphenazine 7.97 µM -1.94006887909094 0.0367970733965162 no 3237 0.0261856597704865 4688 6602611 An atypical antipsychotic. SGTC_1398 3558-0053 112 µM -1.94129212843907 0.0367048054808696 no 3238 0.0261114268868502 4676 4532369 SGTC_1861 st057647 17.4 µM -1.94498686202198 0.036427265507413 no 3239 0.0258882797801193 4671 688668 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.94516881619312 0.036413642017246 no 3240 0.0258773318279857 4643 4000243 SGTC_632 0781-2353 4.65 µM -1.94632175889482 0.036327414403285 no 3241 0.0258080507320434 4698 6811515 YHR007C ERG11 SGTC_593 1203-0218 61.7 µM -1.94686347196086 0.0362869578900775 no 3242 0.0257755524717494 4708 3666956 SGTC_946 3434-1334 87.4 µM -1.9485992229046 0.0361575759366928 no 3243 0.0256716525093773 4647 4047976 SGTC_2456 5770359 74.46 µM -1.95117658530011 0.0359661577890041 no 3244 0.0255180216587874 4632 3118787 SGTC_587 k089-0003 57 µM -1.95550610247652 0.0356464777053114 no 3245 0.0252616818938978 4624 9659696 SGTC_2645 abamectin 100 µM -1.95616992192977 0.0355976695800895 no 3246 0.0252225702367852 4650 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1908 st060353 56.5 µM -1.95732375701665 0.035512962837834 no 3247 0.025154708044962 4659 4227716 SGTC_1096 rimcazole 32.2 µM -1.95753268009036 0.0354976428080196 no 3248 0.0251424367232444 4654 18528119 A dopamine reuptake inhibitor. SGTC_3194 9111903 49.47 µM -1.96040593100351 0.0352875005930775 no 3249 0.0249741815924893 4648 17087251 SGTC_3334 9142812 21.919 µM -1.96525974260117 0.0349348237779569 no 3250 0.024692091226542 4662 45283678 SGTC_1815 st051655 58.2 µM -1.97262873577974 0.0344049294283052 no 3251 0.024268938304225 4661 5984156 SGTC_1751 st044839 27.194 µM -1.97473127147467 0.034254955781148 no 3252 0.0241493260865431 4698 5291326 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.97762741696333 0.0340492543058937 no 3253 0.0239853769770119 4685 5357218 A potent inhibitor of glutathione S-transferases. SGTC_489 paxilline 115 µM -1.97926659559323 0.0339332809377178 no 3254 0.0238929992338591 4646 105008 A toxic potassium channel blocker. SGTC_699 0375-0592 111 µM -1.98024532404313 0.0338641900597915 no 3255 0.0238379846130838 4726 762578 SGTC_980 1473-0395 201 µM -1.98349468089819 0.0336356392616028 no 3256 0.0236561003138424 4636 768876 SGTC_2670 beta-carotene 100 µM -1.98752255442321 0.0333540934436933 no 3257 0.0234322595161209 4699 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1706 st031321 9.9705 µM -1.9976243645498 0.032656511863573 no 3258 0.0228786998700794 4704 6103185 SGTC_2462 5162487 171.77 µM -1.99891913432368 0.0325679775957622 no 3259 0.0228085520408686 4674 2259986 SGTC_1018 4259-0013 28.1 µM -2.00497967380384 0.0321561959219099 no 3260 0.0224826100380738 4704 6801262 SGTC_837 0091-0265 12.5 µM -2.0055173121756 0.0321198747132204 no 3261 0.0224538859261555 4693 759367 SGTC_592 k241-0073 46.5 µM -2.01730137815591 0.0313322484537027 no 3262 0.0218320359487353 4720 4230158 SGTC_1304 1165-0502 251 µM -2.03384879763974 0.0302532694021211 no 3263 0.020983421384236 4694 767425 SGTC_2476 5806916 10.51 µM -2.04045610517655 0.0298311286240894 no 3264 0.0206524593529804 4655 2870194 SGTC_738 1315-0003 72.4 µM -2.04356425219967 0.0296342456301612 no 3265 0.0204983069145308 4691 6251474 SGTC_2220 6782180 200 µM -2.04456700949604 0.0295709573411272 no 3266 0.0204487823782437 4689 833803 SGTC_856 0433-0016 11.3 µM -2.0505201647342 0.0291975343297484 no 3267 0.0201568490464297 4708 3911780 SGTC_977 1348-1378 135 µM -2.0648291162505 0.028315977915934 no 3268 0.0194695859428369 4679 X977 SGTC_1078 idebenone 36.1 µM -2.06798505135899 0.0281245560386203 no 3269 0.0193207143969033 4726 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3244 9134489 49.47 µM -2.06908210218508 0.0280582677666471 no 3270 0.0192691914724726 4705 16584271 SGTC_1758 st042942 75.2445 µM -2.06912218388261 0.0280558483331218 no 3271 0.019267311251258 4673 669317 SGTC_3342 9147791 14.508 µM -2.07374378695016 0.027778039156642 no 3272 0.0190515561449915 4661 1838168 SGTC_2402 5553605 200 µM -2.07475110275071 0.0277177936134728 no 3273 0.019004804248384 4702 6758546 SGTC_481 bay k-8644 50 µM -2.09206229865949 0.0266993457308661 no 3274 0.0182164715779377 4684 2303 A calcium channel antagonist. SGTC_401 neomycin 50 µM -2.09757143593271 0.0263818638909827 no 3275 0.0179715102842779 4707 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2791 5663188 71.43 µM -2.09776445499186 0.0263707980015328 no 3276 0.0179629789565485 4669 54690634 SGTC_2545 solidagenone 89.61 µM -2.10830201251 0.0257725345366655 no 3277 0.0175024369955016 4704 6708572 An anti ulcer agent SGTC_64 000l-0018 272.079 µM -2.11843095794597 0.0252082185823915 no 3278 0.0170692931745544 4624 6811119 SGTC_2707 st078556 66.6 µM -2.12419360951283 0.0248918096558708 no 3279 0.016826978692226 4655 17250899 SGTC_230 MPP+ 141.667 µM -2.12849990921696 0.0246575445332538 no 3280 0.0166478287369436 4703 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1683 st010134 710 nM -2.13106854145162 0.024518692314852 no 3281 0.0165417479603284 4678 3818134 SGTC_556 4058-0063 51.5 µM -2.13581739917335 0.0242637119554684 no 3282 0.0163471501847941 4717 6615692 SGTC_594 1487-1584 10.8 µM -2.15675110080494 0.0231661103644757 no 3283 0.0155125315186945 4713 5013332 SGTC_1988 st071872 53.4 µM -2.16698528342218 0.0226449091232126 no 3284 0.0151179881402468 4739 16414116 SGTC_2693 st077581 40.7 µM -2.17088436892342 0.0224489558041257 no 3285 0.0149699570988492 4675 25238761 SGTC_2496 diffractaic acid 79.83 µM -2.18296364051676 0.0218509517978525 no 3286 0.0145192438579384 4702 94870 An apoptosis inducer which activates caspases. SGTC_2042 p-Dimethylaminoacetophenone 200 µM -2.18297442627614 0.0218504239026756 no 3287 0.0145188466870913 4728 75037 A free radical scavenger. SGTC_1084 voriconazole 435 nM -2.1834583737949 0.0218267487924192 no 3288 0.0145010356015372 4743 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_863 0466-0191 129 µM -2.18726247707994 0.0216414023574259 no 3289 0.0143616841425347 4750 765160 YPR165W RHO1 SGTC_2569 tetrandrine 100 µM -2.19244810874715 0.0213908874939035 no 3290 0.0141735830477367 4706 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_687 k029-0044 34.9 µM -2.22066292857395 0.0200704114132034 no 3291 0.0131869000559111 4752 5829338 SGTC_2533 agelasine 13.65 µM -2.22934179606842 0.0196784042825154 no 3292 0.0128955858483986 4728 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2946 9065502 71.43 µM -2.23169768134299 0.0195731222513859 no 3293 0.0128174753021987 4680 16489101 SGTC_3047 9092122 49.47 µM -2.25214879753746 0.0186791207487682 no 3294 0.0121564352277829 4712 17173831 SGTC_1447 4239-0816 81.9 µM -2.26502702918807 0.0181341851456861 no 3295 0.0117555104503981 4754 1341554 SGTC_1241 0364-0022 50.8 µM -2.26932875265882 0.0179552052560456 no 3296 0.01162417064581 4728 4563895 SGTC_416 estradiol valerate 100 µM -2.27718000911862 0.0176324237866325 no 3297 0.0113877392020406 4726 13791 A steroid. SGTC_2859 9028643 45.46 µM -2.29010250005136 0.0171119374764084 no 3298 0.0110076877438635 4632 17151580 SGTC_1792 st045773 43.6 µM -2.2924261703945 0.0170197521744251 no 3299 0.0109405316576472 4726 2919270 SGTC_1319 1306-0155 43.7 µM -2.29975263340578 0.016731869102987 no 3300 0.0107311191781715 4756 3122360 SGTC_2890 9046729 58.44 µM -2.302583222425 0.0166217660446518 no 3301 0.0106511520152027 4729 903329 SGTC_3215 9129942 49.47 µM -2.32852312865555 0.015641324671914 no 3302 0.00994217129191421 4713 17682944 SGTC_2186 6124449 200 µM -2.34779775472539 0.0149453285024762 no 3303 0.00944238615254838 4754 3834182 YLR033W RSC58 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -2.34782428395373 0.0149443892001588 no 3304 0.00944171368386946 4704 279621 SGTC_1258 0671-0043 57.1 µM -2.3495341679967 0.0148839554541064 no 3305 0.00939845942066254 4737 4298767 SGTC_300 r073-0011 5.04 µM -2.35900737450091 0.0145529300279074 no 3306 0.00916194581271448 4758 2735780 SGTC_2550 chrysin dimethyl ether 71.87 µM -2.36805029591647 0.0142428709243014 no 3307 0.00894105237951432 4702 88881 An O-methylated flavonoid and antioxidant. SGTC_282 k297-0036 65.7 µM -2.37030983141746 0.0141662915857419 no 3308 0.0088865921935635 4743 5061378 SGTC_3007 9078383 71.4286 µM -2.38327194787098 0.0137338044869692 no 3309 0.00857975637547358 4760 6496995 SGTC_684 1140-0066 328 µM -2.40805135843685 0.0129386571290674 no 3310 0.00801896234110641 4752 6813534 SGTC_237 nikkomycin 200 µM -2.42696298929656 0.0123588856969875 no 3311 0.00761290451090241 4765 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_107 0358-0022 2.6945 µM -2.42861658056628 0.0123092785564838 no 3312 0.00757827573072717 4756 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2647 atorvastatin 60.16 µM -2.43371882311106 0.0121572989224815 no 3313 0.0074722995845421 4759 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2391 6285546 200 µM -2.43426629740345 0.012141088429297 no 3314 0.00746100619969389 4751 846083 SGTC_551 k048-0028 34.9 µM -2.43943964022057 0.011988830597921 no 3315 0.00735502993870257 4725 6836383 SGTC_2375 9072683 200 µM -2.48340952772941 0.0107602445516946 no 3316 0.0065065692902895 4767 16798029 SGTC_3260 9137109 49.47 µM -2.49406097501102 0.0104796669949877 no 3317 0.00631454238383981 4763 17478346 SGTC_1744 st037937 38.9 µM -2.49935665945987 0.0103425578750611 no 3318 0.00622095106458879 4758 1016152 SGTC_739 1486-1183 203 µM -2.51513654661821 0.00994323697836583 no 3319 0.00594931450605611 4763 4346692 SGTC_2789 5281112 71.43 µM -2.51739696566609 0.00988715199595333 no 3320 0.00591127714348116 4745 765948 SGTC_881 0833-0569 170 µM -2.54355794667986 0.00925788145730036 no 3321 0.00548649273440521 4774 5418700 SGTC_3271 9137798 49.47 µM -2.54799465491984 0.00915471173374138 no 3322 0.00541720655406625 4771 6498326 SGTC_343 4130-2827 29.8 µM -2.5523048991231 0.00905544805996181 no 3323 0.00535064124044468 4761 1118244 SGTC_298 1391-0729 10 µM -2.56105215465027 0.00885689485730846 no 3324 0.00521778444141761 4750 3237558 SGTC_2221 6807166 181.081 µM -2.56393622945265 0.00879227112972011 no 3325 0.00517462787472225 4780 674925 SGTC_2064 5220758 200 µM -2.62411304235652 0.00753501503386564 no 3326 0.00434374732002858 4773 788518 SGTC_3265 9137266 49.47 µM -2.67011352810959 0.0066835618047229 no 3327 0.00379128023355965 4767 17224265 SGTC_2474 5321570 43.32 µM -2.69761556698442 0.00621616118417145 no 3328 0.00349190195772656 4780 2841384 SGTC_295 k015-0027 31 µM -2.71223286578202 0.00597971576166618 no 3329 0.00334158123727394 4799 3887424 SGTC_763 3453-1109 128 µM -2.73603910294458 0.00561167130780705 no 3330 0.00310918181439288 4779 1560353 SGTC_1363 1636-0063 10.4 µM -2.74274103669967 0.00551175531558594 no 3331 0.0030464357381532 4781 6072185 SGTC_436 n,n-dimethylsphingosine 3.3 µM -2.75142386442725 0.00538465910086598 no 3332 0.00296684055597011 4771 5282309 SGTC_283 0987-0079 11.7 µM -2.77366180669409 0.00507095207774733 no 3333 0.00277146339153043 4785 411556 SGTC_3004 9076122 71.4286 µM -2.7955574982558 0.00477807869091618 no 3334 0.0025905142359107 4784 44782551 SGTC_2486 5283202 22.39 µM -2.81813683991385 0.00449195006077186 no 3335 0.00241516094559849 4771 1377751 SGTC_1916 st067606 49.2 µM -2.85047306349542 0.00410882143133739 no 3336 0.00218271239073723 4733 19590279 SGTC_1970 st070122 35.8 µM -2.85835632626029 0.0040199695351165 no 3337 0.00212920950971219 4780 102928 SGTC_588 3970-1144 52.9 µM -2.873330984542 0.00385591537125262 no 3338 0.00203084170780808 4764 1888707 SGTC_671 0560-0003 407 µM -2.92209644114796 0.00336244003617618 no 3339 0.00173841932136122 4788 3238678 SGTC_1251 0490-5699 265 µM -2.92352539467238 0.00334887739558334 no 3340 0.00173045996663632 4783 3883818 SGTC_1611 st001856 99.4 µM -2.96743253117337 0.0029553894549835 no 3341 0.00150149090564587 4797 647478 SGTC_424 splitomicin 100 mM -3.07737185012238 0.00214641316681902 no 3342 0.00104417305290429 4783 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_355 1311-2252 105 µM -3.07800727646825 0.002142387907026 no 3343 0.00104194913320402 4784 5338538 SGTC_975 1335-0046 28.5 µM -3.16657610018143 0.00164388883585756 no 3344 0.000771224908475698 4791 16486740 SGTC_1972 st070201 17.4 µM -3.20720507164875 0.00145270528524218 no 3345 0.000670157069007877 4800 2829099 SGTC_1907 st060210 83.7 µM -3.25613082302379 0.00124951155119558 no 3346 0.000564708497522507 4797 688793 SGTC_3014 9081533 49.47 µM -3.29408079435022 0.0011101897389029 no 3347 0.000493720556846118 4800 21367265 SGTC_851 0394-0702 453 µM -3.34114263049082 0.000957226735709437 yes 3348 0.000417171746987701 4792 762646 SGTC_2547 epiafzelechin trimethyl ether 100 µM -3.49549511779944 0.000581180296846421 yes 3349 0.000236591554686979 4808 6708630 An antioxidant. SGTC_2454 5-benzylidenerhodanine 10.36 µM -3.62077883990028 0.000382077679068864 yes 3350 0.000146858754584935 4804 1273210 SGTC_3061 glucosamine 200 µM -3.65130060695384 0.000344287188892392 yes 3351 0.000130457813693038 4772 91431 and experimental redox chemotherapeutic SGTC_2641 levomentholum 100 µM -3.70400769203796 0.000287094572893283 yes 3352 0.000106109909219223 4804 16666 SGTC_1851 st056236 18.9 µM -3.75155136566622 0.000243220822212082 yes 3353 8.78718686360045e-05 4803 5393171 SGTC_3269 9137823 49.47 µM -3.85761628263943 0.000166873331536932 yes 3354 5.72491057293643e-05 4807 17682936 SGTC_1213 1315-0166 115 µM -4.0553008912045 8.06483397317354e-05 yes 3355 2.50349038141284e-05 4803 768401 SGTC_3017 9080681 49.47 µM -4.32061404313668 2.88731343172061e-05 yes 3356 7.77978078285543e-06 4808 16451914